diff --git a/.gitattributes b/.gitattributes
index a6344aac8c09253b3b630fb776ae94478aa0275b..60ecaa754903a8b5160cc48e37e6900b31ca8bb3 100644
--- a/.gitattributes
+++ b/.gitattributes
@@ -33,3 +33,4 @@ saved_model/**/* filter=lfs diff=lfs merge=lfs -text
 *.zip filter=lfs diff=lfs merge=lfs -text
 *.zst filter=lfs diff=lfs merge=lfs -text
 *tfevents* filter=lfs diff=lfs merge=lfs -text
+output/biomedbert_vector_db/faiss.index filter=lfs diff=lfs merge=lfs -text
diff --git a/README.md b/README.md
index 91f6a81e9f03ca57cc43d113b24fd00c75757717..3dfd3222276a4e496cfcf735ac8089633f339b41 100644
--- a/README.md
+++ b/README.md
@@ -1,20 +1,290 @@
 ---
-title: Knowledge Extraction From Pathology Reports
-emoji: 🚀
-colorFrom: red
-colorTo: red
-sdk: docker
-app_port: 8501
-tags:
-- streamlit
+title: Pathology RAG System
+emoji: 🔬
+colorFrom: blue
+colorTo: indigo
+sdk: streamlit
+app_file: app.py
 pinned: false
-short_description: Streamlit template space
-license: apache-2.0
 ---
 
-# Welcome to Streamlit!
+![Multimodal RAG Architecture](image.png)
+
+# Visual Architecture Diagram - Pathology Report Knowledge Extraction
+
+## System Architecture - Complete Flow
+
+```
+╔═══════════════════════════════════════════════════════════════════════════════╗
+║                     PATHOLOGY REPORT PROCESSING SYSTEM                        ║
+║                    RAG + Spark NLP + Vector Database                          ║
+╚═══════════════════════════════════════════════════════════════════════════════╝
+
+┌───────────────────────────────────────────────────────────────────────────────┐
+│                           1. DATA INGESTION                                   │
+└───────────────────────────────────────────────────────────────────────────────┘
+
+    📄 Pathology Reports (PDF)
+         │
+         ├─── Scanned PDFs ────────► OCR (Tesseract/EasyOCR)
+         │                                     │
+         └─── Digital PDFs ────────► PyMuPDF Text Extraction
+                                               │
+                                               ▼
+                                      📝 Raw Text Files
+                                               │
+                                               │
+┌──────────────────────────────────────────────┼─────────────────────────────────┐
+│                    2. SPARK NLP PROCESSING   │                                 │
+└──────────────────────────────────────────────┼─────────────────────────────────┘
+                                               │
+                    ┌──────────────────────────┴──────────────────────────┐
+                    │        Spark NLP Medical Pipeline                   │
+                    │                                                      │
+                    │  ┌────────────────────────────────────────────┐    │
+                    │  │  Stage 1: Document Assembly                │    │
+                    │  │  • DocumentAssembler                       │    │
+                    │  │  • SentenceDetector                        │    │
+                    │  │  • Tokenizer                               │    │
+                    │  └──────────────┬─────────────────────────────┘    │
+                    │                 ▼                                   │
+                    │  ┌────────────────────────────────────────────┐    │
+                    │  │  Stage 2: Entity Recognition (NER)         │    │
+                    │  │  • Medical NER (BioBERT/ClinicalBERT)     │    │
+                    │  │  • Extract: PROBLEM, TREATMENT, TEST,      │    │
+                    │  │            ANATOMY, LAB_VALUE              │    │
+                    │  └──────────────┬─────────────────────────────┘    │
+                    │                 ▼                                   │
+                    │  ┌────────────────────────────────────────────┐    │
+                    │  │  Stage 3: Assertion & Relations            │    │
+                    │  │  • AssertionDL (present/absent/possible)   │    │
+                    │  │  • RelationExtraction (entity links)       │    │
+                    │  └──────────────┬─────────────────────────────┘    │
+                    │                                                    │
+                    └─────────────────┼─────────────────────────────────┘
+                                      ▼
+                          📊 Structured Clinical Data
+                          {
+                            "entities": [...],
+                            "relations": [...],
+                            "assertions": [...],
+                            "metadata": {...}
+                          }
+                                      │
+                                      │
+┌─────────────────────────────────────┼───────────────────────────────────────┐
+│                  3. CHUNKING & ENRICHMENT                                    │
+└─────────────────────────────────────┼───────────────────────────────────────┘
+                                      │
+                    ┌─────────────────┴─────────────────┐
+                    │                                   │
+                    ▼                                   ▼
+          ┌──────────────────┐              ┌──────────────────┐
+          │ Section-Based    │              │ Semantic-Based   │
+          │ Chunking         │              │ Chunking         │
+          │                  │              │                  │
+          │ • Clinical       │              │ • 512-1024       │
+          │   History        │              │   tokens         │
+          │ • Findings       │              │ • 128 overlap    │
+          │ • Diagnosis      │              │ • Entity-aware   │
+          │ • Treatment      │              │                  │
+          └────────┬─────────┘              └────────┬─────────┘
+                   │                                 │
+                   └────────────┬────────────────────┘
+                                │
+                                ▼
+                    📦 Enriched Chunks with Metadata
+                    {
+                      "chunk_id": "...",
+                      "text": "...",
+                      "entities": [...],
+                      "section": "...",
+                      "report_date": "...",
+                      "report_type": "..."
+                    }
+                                │
+                                │
+┌───────────────────────────────┼───────────────────────────────────────────┐
+│               4. EMBEDDING GENERATION                                      │
+└───────────────────────────────┼───────────────────────────────────────────┘
+                                │
+                    ┌───────────┴───────────┐
+                    │                       │
+                    ▼                       ▼
+         ┌────────────────────┐   ┌────────────────────┐
+         │ Dense Embeddings   │   │ Sparse Embeddings  │
+         │                    │   │                    │
+         │ • BioBERT          │   │ • BM25             │
+         │ • ClinicalBERT     │   │ • TF-IDF           │
+         │ • PubMedBERT       │   │ • Keyword Index    │
+         │ • SapBERT          │   │                    │
+         │                    │   │                    │
+         │ 768-dim vectors    │   │ Sparse vectors     │
+         └────────┬───────────┘   └────────┬───────────┘
+                  │                        │
+                  └───────────┬────────────┘
+                              │
+                              ▼
+                    🔢 Hybrid Embeddings
+                              │
+                              │
+┌─────────────────────────────┼─────────────────────────────────────────────┐
+│               5. VECTOR DATABASE STORAGE                                   │
+└─────────────────────────────┼─────────────────────────────────────────────┘
+                              │
+              ┌───────────────┼───────────────┐
+              │               │               │
+              ▼               ▼               ▼
+      ┌──────────────┐ ┌──────────────┐ ┌──────────────┐
+      │  ChromaDB    │ │    FAISS     │ │  Pinecone    │
+      │              │ │              │ │              │
+      │ • Dev/Test   │ │ • Production │ │ • Cloud      │
+      │ • Easy setup │ │ • Fast       │ │ • Managed    │
+      │ • Metadata   │ │ • Scalable   │ │ • Enterprise │
+      └──────┬───────┘ └──────┬───────┘ └──────┬───────┘
+             │                │                │
+             └────────────────┼────────────────┘
+                              │
+                              ▼
+                  💾 Indexed Knowledge Base
+                  • Embeddings: 384-768 dims
+                  • Metadata: entities, dates, types
+                  • Relations: entity graphs
+                              │
+                              │
+┌─────────────────────────────┼─────────────────────────────────────────────┐
+│                     6. QUERY & RETRIEVAL (RAG)                             │
+└─────────────────────────────┼─────────────────────────────────────────────┘
+                              │
+         👤 User Query: "What are ER+ breast cancer markers?"
+                              │
+                              ▼
+              ┌───────────────────────────────┐
+              │   Query Processing            │
+              │   • Entity extraction         │
+              │   • Query expansion           │
+              │   • Generate embeddings       │
+              └───────────┬───────────────────┘
+                          │
+                          ▼
+              ┌───────────────────────────────┐
+              │   Hybrid Retrieval            │
+              │                               │
+              │   ┌─────────────────────┐    │
+              │   │ Dense Search        │    │
+              │   │ (Semantic)          │────┼──► Top 20 chunks
+              │   └─────────────────────┘    │
+              │                               │
+              │   ┌─────────────────────┐    │
+              │   │ Sparse Search       │    │
+              │   │ (BM25/Keywords)     │────┼──► Top 20 chunks
+              │   └─────────────────────┘    │
+              │                               │
+              │   ┌─────────────────────┐    │
+              │   │ Entity Filter       │    │
+              │   │ (Medical entities)  │────┼──► Filtered
+              │   └─────────────────────┘    │
+              └───────────┬───────────────────┘
+                          │
+                          ▼
+              ┌───────────────────────────────┐
+              │   Reranking                   │
+              │   • Cross-encoder scoring     │
+              │   • Medical relevance         │
+              │   • Temporal filtering        │
+              └───────────┬───────────────────┘
+                          │
+                          ▼
+                  📚 Top 5-10 Relevant Chunks
+                          │
+                          │
+┌─────────────────────────┼───────────────────────────────────────────────┐
+│                 7. GENERATION (LLM)                                       │
+└─────────────────────────┼───────────────────────────────────────────────┘
+                          │
+                          ▼
+          ┌───────────────────────────────────┐
+          │   Prompt Construction             │
+          │                                   │
+          │   System: "You are a medical      │
+          │            expert assistant..."   │
+          │                                   │
+          │   Context: [Retrieved chunks]     │
+          │                                   │
+          │   Query: [User question]          │
+          │                                   │
+          │   Instructions: "Answer with      │
+          │                  citations..."    │
+          └───────────┬───────────────────────┘
+                      │
+                      ▼
+          ┌───────────────────────────────────┐
+          │   LLM (Claude/GPT-4/Med-PaLM)    │
+          │                                   │
+          │   • Medical reasoning             │
+          │   • Citation generation           │
+          │   • Accuracy validation           │
+          └───────────┬───────────────────────┘
+                      │
+                      ▼
+          ┌───────────────────────────────────┐
+          │   Post-processing                 │
+          │   • Format citations              │
+          │   • Fact checking                 │
+          │   • Safety validation             │
+          └───────────┬───────────────────────┘
+                      │
+                      ▼
+                  💬 Final Response
+                      │
+                      │
+┌─────────────────────┼─────────────────────────────────────────────────┐
+│             8. USER INTERFACE                                           │
+└─────────────────────┼─────────────────────────────────────────────────┘
+                      │
+        ┌─────────────┼─────────────┐
+        │             │             │
+        ▼             ▼             ▼
+   ┌────────┐   ┌─────────┐   ┌──────────┐
+   │  CLI   │   │ Web UI  │   │ REST API │
+   │        │   │         │   │          │
+   │ Python │   │Streamlit│   │ FastAPI  │
+   │ Script │   │ Gradio  │   │          │
+   └────────┘   └─────────┘   └──────────┘
+        │             │             │
+        └─────────────┼─────────────┘
+                      │
+                      ▼
+              📊 User Gets Answer
+              with Citations & Sources
+
+
+╔═══════════════════════════════════════════════════════════════════════════╗
+║                        SUPPORTING COMPONENTS                              ║
+╚═══════════════════════════════════════════════════════════════════════════╝
+
+┌─────────────────────┐  ┌─────────────────────┐  ┌────────────────────────┐
+│  Monitoring &       │  │  Knowledge Graph    │  │  Caching Layer         │
+│  Logging            │  │  (Optional)         │  │                        │
+│                     │  │                     │  │  • Query cache         │
+│  • MLflow           │  │  • Neo4j            │  │  • Embedding cache     │
+│  • W&B              │  │  • NetworkX         │  │  • LLM response cache  │
+│  • Prometheus       │  │  • Entity graphs    │  │  • Redis/Memcached     │
+└─────────────────────┘  └─────────────────────┘  └────────────────────────┘
+
+┌─────────────────────┐  ┌─────────────────────┐  ┌────────────────────────┐
+│  Security &         │  │  Evaluation         │  │  Data Pipeline         │
+│  Compliance         │  │  Metrics            │  │                        │
+│                     │  │                     │  │  • Apache Airflow      │
+│  • De-identification│  │  • Precision@k      │  │  • Spark jobs          │
+│  • HIPAA compliance │  │  • Medical accuracy │  │  • Batch processing    │
+│  • Access control   │  │  • Latency          │  │  • ETL workflows       │
+└─────────────────────┘  └─────────────────────┘  └────────────────────────┘
+
+═══════════════════════════════════════════════════════════════════════════
+                            END-TO-END FLOW
+═══════════════════════════════════════════════════════════════════════════
+
+
 
-Edit `/src/streamlit_app.py` to customize this app to your heart's desire. :heart:
 
-If you have any questions, checkout our [documentation](https://docs.streamlit.io) and [community
-forums](https://discuss.streamlit.io).
diff --git a/app.py b/app.py
new file mode 100644
index 0000000000000000000000000000000000000000..efa8d4c4b08de8143d47f1db21c1213eec44e4d6
--- /dev/null
+++ b/app.py
@@ -0,0 +1,164 @@
+#!/usr/bin/env python3
+"""
+Pathology RAG System - Streamlit Version
+Query existing FAISS database
+"""
+
+import os
+import sys
+from pathlib import Path
+from datetime import datetime
+
+import streamlit as st
+
+# Force CPU
+os.environ["CUDA_VISIBLE_DEVICES"] = ""
+
+# Add src folder
+sys.path.append("src")
+
+DB_PATH = "output/biomedbert_vector_db"
+
+if not Path(DB_PATH).exists():
+    st.error("Vector database not found. Upload output/biomedbert_vector_db.")
+    st.stop()
+
+# Import RAG pipeline
+try:
+    from retriever import CompleteRAGPipeline
+except ImportError as e:
+    st.error(f"Import error: {e}")
+    st.stop()
+
+
+# -----------------------------
+# Load Pipeline (cached)
+# -----------------------------
+
+@st.cache_resource
+def load_pipeline():
+    # Cache busted to pick up the new ask method return dictionary
+    pipeline = CompleteRAGPipeline(
+        faiss_db_path=DB_PATH,
+        embedding_model="microsoft/BiomedNLP-BiomedBERT-base-uncased-abstract-fulltext",
+    )
+
+    return pipeline
+
+
+pipeline = load_pipeline()
+
+
+# -----------------------------
+# Page Config
+# -----------------------------
+
+st.set_page_config(
+    page_title="Pathology RAG",
+    layout="wide"
+)
+
+st.title("🔬 Pathology Report Analysis System")
+
+st.markdown(
+"""
+AI-powered search and question answering over pathology reports  
+Vector database powered by **BiomedBERT + FAISS**
+"""
+)
+
+
+# -----------------------------
+# Session State
+# -----------------------------
+
+if "query_count" not in st.session_state:
+    st.session_state.query_count = 0
+
+
+# -----------------------------
+# Sidebar
+# -----------------------------
+
+st.sidebar.header("System Info")
+
+st.sidebar.write(f"Queries: {st.session_state.query_count}")
+
+st.sidebar.write("Embedding Model:")
+st.sidebar.write("BiomedBERT")
+
+st.sidebar.write("Vector DB:")
+st.sidebar.write("FAISS")
+
+
+# -----------------------------
+# Query Input
+# -----------------------------
+
+st.header("🔎 Ask a Question")
+
+question = st.text_area(
+    "Enter your medical query",
+    placeholder="What are common findings in breast cancer pathology?",
+)
+
+num_sources = st.slider(
+    "Number of sources",
+    min_value=1,
+    max_value=10,
+    value=5
+)
+
+
+# -----------------------------
+# Search Button
+# -----------------------------
+
+if st.button("Search"):
+
+    if question.strip() == "":
+        st.warning("Please enter a question.")
+
+    else:
+
+        with st.spinner("Running RAG pipeline..."):
+
+            st.session_state.query_count += 1
+
+            result = pipeline.ask(
+                question,
+                top_k=num_sources
+            )
+
+        answer = result["answer"]
+
+        st.subheader("Answer")
+
+        st.markdown(answer)
+
+
+        # Metadata
+        st.subheader("Query Info")
+
+        st.write({
+            "query_number": st.session_state.query_count,
+            "timestamp": datetime.now().strftime("%Y-%m-%d %H:%M:%S"),
+            "sources_used": result["num_sources"]
+        })
+
+
+        # Sources
+        st.subheader("Sources")
+
+        sources = result["sources"]
+
+        if not sources:
+            st.write("No sources retrieved.")
+
+        for i, source in enumerate(sources, 1):
+
+            chunk = source["chunk"]
+
+            with st.expander(f"Source {i} | {chunk['filename']}"):
+
+                st.write(chunk["text"][:600])
\ No newline at end of file
diff --git a/image.png b/image.png
new file mode 100644
index 0000000000000000000000000000000000000000..a125252030a844b8a016eba64b115182fe3897d6
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diff --git a/output/.DS_Store b/output/.DS_Store
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diff --git a/output/biomedbert_vector_db/faiss.index b/output/biomedbert_vector_db/faiss.index
new file mode 100644
index 0000000000000000000000000000000000000000..c5bde9c9b9a699539cf081ec7324670aacc5c768
--- /dev/null
+++ b/output/biomedbert_vector_db/faiss.index
@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:13e528783241822262d42f011636618870f54d84c8cbbaffdf7a21fa92dd0d2f
+size 30584877
diff --git a/output/biomedbert_vector_db/metadata.pkl b/output/biomedbert_vector_db/metadata.pkl
new file mode 100644
index 0000000000000000000000000000000000000000..e61e63ebf0f71424e8f74ff2b50daf9b9b7b36c0
--- /dev/null
+++ b/output/biomedbert_vector_db/metadata.pkl
@@ -0,0 +1,3 @@
+version https://git-lfs.github.com/spec/v1
+oid sha256:1138cbbb3cd4e2cec0f626bb88d412b95e22a0cc77c4d291cb35f5757a86c925
+size 10202202
diff --git a/output/biomedbert_vector_db/stats.json b/output/biomedbert_vector_db/stats.json
new file mode 100644
index 0000000000000000000000000000000000000000..39290e32239987d3e7e3e071827351aea91915bb
--- /dev/null
+++ b/output/biomedbert_vector_db/stats.json
@@ -0,0 +1,5 @@
+{
+  "files_processed": 2257,
+  "total_chunks": 9956,
+  "timestamp": "2026-04-01T16:03:19.178128"
+}
\ No newline at end of file
diff --git a/output/text/00103fa2-43e4-4c6a-babb-d8b46612399e.txt b/output/text/00103fa2-43e4-4c6a-babb-d8b46612399e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3144d8878cfb41bf5ffb15c1e98978308e9d16cd
--- /dev/null
+++ b/output/text/00103fa2-43e4-4c6a-babb-d8b46612399e.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:C8BBFFAA-4A45-44D3-921B-6F2BD8DB5B19 TCGA-XS-A8T3-01A-PR Redacted IcD-0-3 8072]3 QruyNbS C 53.oy Nature of material: Cervix tJ 1|Z 4f14 ANATOMOPATHOLOGIC RESULT MACROSCOPY Specimen consists of the uterus and left fallopian tube, weighing 559.0 grams. The tube measures 9.0 cm in length and diameter ranges between 6.0 and 1.5 cm. To the cuts the wall is thin, measuring 0.1 cm, the light is dilated and filled with hemorrhagic content. The uterus measures 13.5 cm in its longitudinal axis, 8.0 cm in anteroposterior diameter and 8.5 cm in bicorneal distance. The cervix measures 3.7 cm in diameter and is surrounded by the vaginal dome, measuring between 0.7 and 1.2 cm. It is observed hard and ulcerated lesion with poorly defined edges and granular background, measuring 3.4 x 3.0 cm, involving all quadrants of the cervix. To the cuts, the myometrium measures 7.8 cm at the bottom, which is thicker, and it has multiple round, firm and whitish lesions, with crisscrossing beams. The endometrium measures 0.4 cm. MICROSCOPY Dispensable description.. DIAGNOSTIC Product of hysterectomy and left salpingectomy: -Invasive squamous cell carcinoma, non-keratinizing, moderately differentiated measuring 3.4 x 3.0 cm in major axis and infiltrating the stroma until 1.38 cm in depth and 2.8 cm in horizontal extent, without compromising uterine isthmus or circumferential and vaginal resection margins.. - Presence of extensive component by squamous cell carcinoma in situ.. - Presence of neoplastic lymphatic embolization. - Uterine leiomyomas. - Endometriosis in parametrium bilaterally and in the left fallopian tube. - Dysfunctional endometrium with moderate stromal edema. - Pathological staging: pT1b1, pN1 (TNM 7th). - For lymph node biopsy, see biopsy number  in this service.
\ No newline at end of file
diff --git a/output/text/0010ce59-fd1e-4a45-8753-a224164fb818.txt b/output/text/0010ce59-fd1e-4a45-8753-a224164fb818.txt
new file mode 100644
index 0000000000000000000000000000000000000000..25f71cdbcb5445ca439dd9f4dd2333e013e85fea
--- /dev/null
+++ b/output/text/0010ce59-fd1e-4a45-8753-a224164fb818.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+page 1 / 2 Department of Cancer Pathology copy No. Date: Examination: Histopathological examination Examination No.: Cost of diagnostic procedure Internal invoice No. Age: ender: F pesel: xXx Patient: XXX 1cs-0-3 Material: Total organ resection -- left breast ad axillary tissues Caci oma, nf {tatv7 duct,Nos 85oxf3 Sih:bus# N0s c5o.9 p~ q1a|1 Unit in charge: (  Physician in charge: Material received on: : Material collected on: Expected time of examination: up to 8 working days Clinical diagnosis: Examination performed on: Macroscopic description: Left breast'sized 24 x 19.5 x 5 cm removed with axillary tissues sized 10 x 7 x 2.5 cm and a skin flap of 24 x 12 cm. Tumour sized 1.9 x 1.3 x 1.4 found in the subaurolar part, located 5.2 cm from the upper boundary, 2.8 cm from the base and 0 cm from the  skin. Metastatic lymph nodes 2 cm in length. Microscopic description:. Carcinoma ductale invasivum - NHG2 (3 + 2 + 1 / 6 mitoses/10 HPF - visual area 0.55 mm) Foci of carcinoma ductaie in situ Dcis detected within the tumour (cribrate and solid type with high nuclear atypia with comedo necrosis, 5% of the tumour). Mamilla sine laesionibus. Glandular tissue showing lesions of the type mastopathia fibrosa. AXILLARY LYMPH NODES  Metastases carcinomatosae in lymphonodis (No ix/xv). Infiltratio capsulae lymphonodis et telae perinodalis. Histopathological diagnosis: Carcinoma ductale invasivum et ductale in situ mammae sinistrae. Invasive ductal and in situ ductal carclrioma of the feft breast Metastases carcinomatosae in lymphonodis axillae (No Ix/xv). Cancer metastases of the axillary lymph nodes (No Ix/xv). (NHG2, pTIc, pN2a). UUID:53ED4388-8CD2-4925-81A9-9C4792C83566 TCGA-D8-A1Y0-01A-PR Redacted Hef1
+
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+page 2 / 2 Compliance validated by: Examination performed on: Results of immunohistochemical examination: Estrogen receptors found in over 75% of neoplastic cell nuclei. Progesterone receptors found in over 75% of neoplastic cell nuclei. HER2 protein stained with HercepTestTM by DAKO.  Negative reaction in invasive cancerous cells ( Score = 1+ ) CONTACT YOUR DOCTOR WITH THIS REPORT!
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diff --git a/output/text/00157a93-7d77-41d8-ac9c-6317c9ae38fe.txt b/output/text/00157a93-7d77-41d8-ac9c-6317c9ae38fe.txt
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index 0000000000000000000000000000000000000000..25edabf195b025c0c4f7520127c6013e7d65c03c
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+Jcs-0 - 3 Curcinonn mf1tnaHnz ductul,nsos 850t/3 Sih: BUsotj LbQ C50.5 1/21n h Pish Sit: Brst, Nos c5o.9 CqcF Diagnosis: Right-sided breast excision material with a poorly differentiated inyasive ductal breast. carcinoma measuring about 4.3 cm with invasion of the lymph vessels and a minimum margin. of 3 mm at 6 o'clock and 10 mm at 12 o'clock and 1.5 cm or more at 3 and 9 o'clock. No intraductal tumor component. Tumor classification: M-8500/3, G 3, pT 2, pN 3a (14/28), pMx, stage III c. R 0. 40FA-823A-E608ABFEF591 Redacted
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diff --git a/output/text/001fee13-0e0d-464d-8b18-5641d51c86db.txt b/output/text/001fee13-0e0d-464d-8b18-5641d51c86db.txt
new file mode 100644
index 0000000000000000000000000000000000000000..392cd10d9a937bbc2eeec3fd7a3e96ce72b32d04
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SPECIMENS: A. RIGHT COLON DIAGNOSIS: A. RIGHT COLON, RIGHT HEMICOLECTOMY: - EXOPHYTIC CIRCUMFERENTIAL ULCERATED INVASIVE MODERATE TO POORLY DIFEERENTIATED ADENOCARCINOMA OF CECUM. PROXIMAL ASCENDING COLON WITH EXTENSION TO ILEOCECAL VALVE, WITH FULL MUSCLE WALL THICKNESS INVASION, EXTENSION TO SUB- SEROSAL FAT., METASTASIS TO SIX OF THIRTY-SIX (6/36) PERICOLIC LYMPH NODES (WITH PERINODAL FAT EXTENSION). - SIZE OF TUMOR- 8 X 4 X1 CM. - TUBULOVILLOUS ADENOMA (1.2 X 1.1 CM). - VERMIFORM APPENDIX - NEGATIVE FOR TUMOR - PROXIMAL, DISTAL AND RADIAL MARGINS OF RESECTION - NEGATIVEE FOR TUMOR. COLORECTAL CANCER TEMPLATE Specimen Type: Right hemicolectomy Tumor Site: Cecum,proximal ascending coln. Tumor Configuration: Exophytic (polypoid), Infiltrative, Ulcerating Tumor Size: 8.0 x 4.0 x 1.0 cm Histologic Type: Adenocarcinoma Histologic Grade: G3 Extent of Invasion:  Subserosa Margins:  Margins uninvolved by invasive carcinoma  Venous/Lymphatic Invasion: Present Perineural Invasion: Present Additional Pathologic Findings: Adenoma Extent of Resection: R0 Positive (6/36) Lymph Nodes:  Implants: Absent EGFR Expression: Pending Pathologic Stage: pT3 N2 MX ADDENDUM: Additional report: Results of immunostain: EGFR ( section with tumor,#A5) - negative immunoreactivity. SPECIMEN(S): A. RIGHT COLON GROSS DESCRIPTION: A. RIGHT COLON TERMINAL ILEUM: Received fresh labeled with the patient's name, unit number and "right colon terminal ileum' is a 28.5x8.5x4 cm. right hemicolectomy specimen. The ileum is 8 cm. long and 7 cm. in circumference, the colon is 20.5 cm. Iong, 8.5 cm. in circumference and the attached appendix is 5.8 cm. long and 0.9 cm. in diameter. The serosal surface of the specimen is tan, smooth and multiple firm lymph nodes are palpated throughout the adherent pericolonic fat at the cecum. The specimen when opened shows a circumferential exophytic centrally ulcerated tumor with raised indurated peripheral borders occupying proximal ascending colon,cecum, and extending to involved the iliocecal valve,measuring 8x4x1.0 cm.
+
+--- Page 2 ---
+Tumor 14.5 cm from distal,and 5.5cm from proximal margin.Cut sections show tan white granular surface.and tumor seen infiltrating muscle wall and grossly appears to extend to subjacent subserosal fat. The rest of colonic mucosa shows a flattened appearance .with a small polyp along hepatic flexure measuring 1.2x1.1 cm. Dissection of the adherent pericolonic fat shows multiple lymph nodes,the Iargest measuring 2x1.1x0.9 cm. Appendix is grossly free of tumor. Multiple sections submitted as follows in 30 cassettes labeled A1-A17.  Block summary: A1: margin A2: apex A3,A4,A5,A6: tumor and tandom section from ileum to colon A7,A8: tumor A9-A11: tumor deep section A12: polyp A13: three lymph nodes ileum. A14: three lymph nodes ileum A15 lymph nodes cecum colon A16: lymph nodes cecum colon A17: two lymph nodes distal colon A19-21: lymph nodes distal colon A26-30: sections of tumor, A29 and A30 are random sections
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diff --git a/output/text/004d2c0d-6209-43f1-900e-fc8d923dd9b5.txt b/output/text/004d2c0d-6209-43f1-900e-fc8d923dd9b5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6919954a41a72ec20e4b201cc747cc9574c4758b
--- /dev/null
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+
+--- Page 1 ---
+UUID:654A67F7-8755-4BF6-9674-69ADA7C976DA TCGA-TM-A84H-01A-PR Redacted Repor Final Updatec Page 2 DOCTOR DOC. ADDRESS COLL. DATE DATE RECEIVED WARD CONSULTANT ISTOPATHOLOGY REPORT COPY TO: SUPPLEMENTARY AND FINAL REPORT SPECIMEN: A. Right frontal tumour. B. Right frontal tumour. C Tumour. Further tissue sections of the glioma have been. examined, additional immunohistochemical studies performed, and Fish results finalized. Examination: of the additional sections of the glioma, which is now been examined in its entirety, reveals similar microscopic appearances to those initially report.  Variable cytoarchitectural patterns are evident, ranging from sparsely cellular microcystic, through to microscopic nodular areas where the neoplastic cells aggregate closely, and have a variably pleomorphic and hyperchromatic nuclei, minimal cytoplasm, and demonstrates some nuclear angulation and irregularity. No areas of vascular endothelial proliferation or palisading necrosis have been identified. Maximal mitotie counts within the hypercellular areas, seven mitotic figures per 10 high power fields (field area 0.196 mm squaredl. The proliferation index, as judged by immunohistochemical staining for the proliferation marker Mrs I is variable.  Low-grade and sometimes microcystic areas typically have low MIs 1 indices, with relatively raxe nuclear labelling, but the small hypercellular foci demonstrate elevated labelling. Immunohistochemical staining for p53 protein demonstrates no convincing nuclear positivity.  Synaptophysin staining is evident in many of the neoplastic cells, particularly in hypercellular foci, and takes the form of granular cytoplasmic 0 positivity, sometimes with perinuclear dot like exenteration. There is no convincing positivity for NeuN, which highlights scattered mononuclear neuronal cells, which do not demonstrate abnormal clustering or cytologic features such as binucleation. Neurofilament highlights this non-neoplastic population, together with an entrapped network of processes of background neuropii. Representative formalin fixed paraffin embedded tissue sections were submitted 9382/3 for FIsh (fluorescence in situ. hybridization] studies to assess lp, 19q and The results of the studies (which have been reported separately) demonstrated no loss of Ip and no loss of 19q, and Ecrr amplification was not detected. C71.0 In summary, considering these results and additional findings, this diffuse glioma is perhaps best regarded as a diffuse wHo Grade IIl mixed oligo- astrocytoma, conctusion: Right frontal tumor. wHo Grade IIl mixed oligo-astrocytoma, lacking ip and 19q deletions, and demonstrating no evidence Egrr amplification. Comment: Grading of oligoastrocytomas is a problematic area in surgical neuropathology. There is no specific grading scheme for oligoastrocytoma in the most recent wHo Classification of Tumors of the CNs. In grading oligoastrocytoma, many authorities now adopt the same grading scheme as used for oligodendroglioma. . The minimum criteria for a diagnosis of who Grade III anaplastic glioma in this setting are not well defined. Many authorities regard mitotic activity [greater than 5 mitotic figures per 10 high power fields] as a
+
+--- Page 2 ---
+valuable parameter of anaplasia in the absence of endothelial proliferation, palisading necrosis, or frankly anaplastic cytology and hypercellularity. In this case, overt features of anaplasia are not evident, but the maximal mitotic count exceeds 5 mitotic figures per 10 high power fields, and in hypercellular foci the MIs 1 determined proliferation index is relatively high. As such, the findings are int amount to a wHo grade III oligoastrocytoma. PATHOLOrr em. DATED: ELECTRONICALLY VALIDATED: END OF REPORT FOR Page 2 DOCTOR Doc. ADDRESS COLL. DATE DATE RECEIVED CONSULTANT HISTOPATHOLOGY REPORI COPY TO: SPECIMEN: A. Right frontal tumour. B. Right frontal tumour. C. Tumour. CLINICAL: Low grade frontal glioma.. MACROSCOPIC: A.  One piece of grey-white tissue approximately 6 x 6mm. A second smaller piece 2 x 2mm. Larger piece submitted for frozen sections and imprint cytology. A INTRA-OPERATIVE ASSESSMENT - FROZEN SECTION / IMPRINT CYTOLOGY: Glial neoplasm, grade 2-3.. Result phoned to B.  Multiple irregular fragments of tan coloured tissue with areas of haemorrhage and myxoid change. Specimen is sectioned and reveals a white and grey matter differentiation.  Several pieces of brain tissue. The largest measures 5Omm x 30mn x 30mm. Tissue is serially sectioned and reveals a creamy cut surface with areas showing myxoid change and haemorrhage. Centrally, the specimen is very friable and the tissue has a soft consistency.. MICROSCOPIC: A. C.  The specimens have been thoroughly sampled and show extensive malignancy.  In some areas it shows an oedematous appearance with a "fried egg' pattern and there is infiltration into grey matter with peri-neuronal satellitosis. The cells have round to oval slightly irregular nuclei with granular chromatin and inconspicuous nucleoli. Mini-gemistocytes are also seen. The background appears fibrillary. Elsewhere the tumour is more cellular and arranged either in sheets or in alternating hyper and hypocellular areas. The cells have larger, more pleomorphic nuclei, coarsely granular chromatin and inconspicuous nucleoli. 'Mini-gemistocytes are still present.. The background appears myxoid and there is microcystic change containing mucoid material. Scattered mitotic figures are noted.. There is no endothelial proliferation or necrosis identified. CONCLUSION:
+
+--- Page 3 ---
+A. - C. Right frontal tumour: Glial series tumour with oligodendroglial features. The cellularity, atypia and mitotic activity are consistent with an anaplastic oligodendroglioma (who grade IIl), cytogenetic. studies are proceding to confirm this and a supplementary report will be issued. REGISTRAR: PATHOLOGIST: DATED: as ELECTRONICALLY VALIDATED: END OF REPORT FOR
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diff --git a/output/text/004e158d-aac7-461f-be6e-f3bdcde20224.txt b/output/text/004e158d-aac7-461f-be6e-f3bdcde20224.txt
new file mode 100644
index 0000000000000000000000000000000000000000..cd3d703154ef19e1a737348f08c98b088c62a31c
--- /dev/null
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+Diagnosis: Resected ileocolic material displaying in the colon ascendens, located 2 cm distal to the ileocecal valve, an adenocarcinoma of colorectal type measuring a maximum of 4 cm in diameter, ulcerated, moderately differentiated and with infiltration of the perifocal adipose tissue. Tumor-free lymph nodes in this region. Tumor-free small and large intestine resection margins. Tumor-free mesenteric resection margin. Tumor-free appendix. Tumor-. free omental adipose tissue. Tumor stage therefore pT3, pN0 (0/39) pMX; G2, L0, V0, local R0
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diff --git a/output/text/0077ff5b-55d3-4dca-80c0-fe5527b77362.txt b/output/text/0077ff5b-55d3-4dca-80c0-fe5527b77362.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5a92684798e61660f78edb0846d7f12289937de3
--- /dev/null
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+
+--- Page 1 ---
+IGDo 3 UUID:5A59F9F1-9F37-468D-B120-B12C92E2C474 TCGA-VR-AA4D-01A-PR Redacted Site: Espnagus, olstal thud C15.5 Q0s3|5/14 Collect date: (MM/DD/YYYY) PATHOLOGY REPORT: PRIMARY SITE: Esophagus (Distal) 1-"Product of esophagogastrectomy"':. Moderately differentiated adenocarcinoma with papillary areas infiltrative up to submucosa. Presence of lymphatic invasion. Perineural infiltration not detected.. Infiltrative growth pattern. Absence of necrosis. Discrete peritumoral inflammatory infiltrate. Surgical margins free of neoplastic compromise. 2-"Lymphadenectomy according to standardization"': Metastatic adenocarcinoma in 6 of 25 identified lymph nodes (6/25), with no capsular compromise, distributed as follows:. 1/2 right cardiac; 2/7 left cardiac, 0/13 lesser curvature; 3/3 left gastric artery; 0/0 celiac trunk; 0/0 inferior para-esophageal. 3- "Greater omentum": Free of neoplastic compromise. 4-"Esophageal margin": Free of neoplastic compromise. 194
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diff --git a/output/text/00a7f79f-49bd-46b9-bde2-1a28ac6eecce.txt b/output/text/00a7f79f-49bd-46b9-bde2-1a28ac6eecce.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9fdf45532c673893ee528cb5ef442752a21a69ce
--- /dev/null
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+
+--- Page 1 ---
+UUID:9A8F7726-D97C-44DE-B72F-6BF0FC2078F8 TCGA-LL-A73Y-01A-PR Redacted RUN DATE: PAGE 1 RUN TIME: RUN USER: r PATIENT: ACCT #: LOC: AGE/SX :  ROOM: REG DR: DOB: BED: STATUS : SPEC #: RECD: STATUS: COLL: TIME IN FORMALIN: "hrs. COLD ISCHEMA TIME: mins. CLINICAL INFORMATION: Pre-Op Diagnosis: Remarks: Specimen(s): A. Right sentinel node B. Right breast for tissue banking Ecd-6.3 scnima, d yiltetis ductNDS U 8s$oL3 ICROSCPIC IIAGNOSIS S.iti  Buast4oS CsP9 A. ONE LYMPH NODE, RIGHT SENTINEL NODE. LYMPHADENECTOMY: IMMUNOCHEMICAL STAINS B. RIGHT BREAST. TOTAL MASTECTOMY: INFILTRATING DUCTAL CARCINOMA MODIFIED NOTTINGHAM HISTOLOGIC GRADE 3 OF 3: NUCLEAR SCORE 3 OF 3. TUBULAR FORMATION SCORE 3 OF 3. MITOTIC SCORE 2 OF 3 (5 MITOTIC FIGURES PER SQUARE MILLIMETER) NO DUCTAL CARCINOMA IN SITU IDENTIFIED INVASIVE TUMOR MEASURES 17 MM SURGICAL MARGINS FREE OF TUMOR WITH NEAREST MARGIN 7 MM FROM TUMOR. THE DEEP MARGIN SEE COMMENT FOR SYNOPTIC REPORT COMMENT(S) SURGICAL PATHOLOGY CANCER CASE SUMMARY - APPROVED BY COLLEGE OF AMERICAN PATHOLOGISTS PROCEDURE : Total mastectomy LYMPH NODE SAMPLING: Sentinel lymph node(s) SPECIMEN LATERALITY: Right TUMOR SIZE: Greatest dimension of largest focus of invasion:. 17 mm HISTOLOGIC GRADE (NOTTINGHAM HISTOLOGIC SCORE) : Glandular/tubular differentiation: score 3. Nuclear pleomorphism: score 3 Mitotic rate: score 2 Overall grade: grade 3 TUMOR FOCALITY: Single focus of invasive carcinoma. DUCTAL CARCINOMA IN SITU: No DcIs is present ** CONTINUED ON NEXT PAGE **
+
+--- Page 2 ---
+RUN DATE: PAGE 2 RUN TIME: RUN USER: SPEC #: PATIENT : (Continued) COmmenT(S) (Continued) MARGINS : Invasive carcinoma: Margins uninvolved by invasive carcinoma Distance from closest margin: 7 mm, deep LYMPH NODES: Number of sentinel lymph nodes examined: Number of lymph nodes with macrometastases: 0 Number of lymph nodes with micrometastases: PATHOLOGIC STAGING: Primary tumor: pT1c Regional lymph nodes: pN0 (i-) Distant metastases: Not applicable ANCILLARY STUDIES: Estrogen receptor: Results: negative (<1% of tumor cells with nuclear positivity) Progesterone receptor: Results: negative (<1% of tumor cells with nuclear positivity) HER-3: Immunoperoxidase studies: Results: negative (score 0) GROSS DESCRIPTION: The specimen is received in two parts. Both parts are received labeled with the patient's name. A. Received in formalin. labeled with the patient's name and "right sentinel node" is a 3.5. x 2.5 x 2.0 cm portion of yellow. lobulated adipose. The adipose is trimmed to have a. flattened. 2.6 x 2.0 x 0.6 cm nodular. fatty lymph node. The node is sectioned perpendicular to the long axis to be entirely submitted per sentinel lymph node protocol cassettes Al-A3. B. Received fresh for tissue banking. labeled with the patient's name and "right breast" is a 962 gram. 23.0 x 20.0 x 4.5 cm fibrofatty breast consistent with simple mastectomy specimen. There is a suture designating the region of the axilla and an overlying 12.5 x 4.5 cm black-brown skin ellipse. The skin ellipse has a central. 5.0 x 4.5 cm areola which extends to the skin margins and a central 1.3 cm erect nipple. The deep margin is predominantly smooth and intact with a focal. minor. inferior medial area of disruption. The deep margin will be inked blue and the breast is serially sectioned to have a diffusely fatty parenchyma. The upper inner quadrant has a 1.7 x 1.0 x 0.8 cm tumor mass. The mass. is 2.5 cm from the superior peripheral margin. The . is 17 cm from the inferior peripheral margin. is approximately 4 cm from the medial peripheral margin and at least 16.5 cm from ths lateral peripheral margin. The tumor comes to within 0.7 cm of the deep margin. The remainder of the breast has glistening, yellow adipose with diffuse. delicate and focal scant dense-white fibrous tissue. There is a central area of possible fibrocystic change. The white fibrous tissue makes up between 15 and 20% of the parenchyma and is more pronounced towards the medial aspect of the breast. No additional indurated lesions or tumor-like masses are identified. Representative sections are sampled as labeled: B1 perpendicular section of nipple B2 section of tumor adjacent to tumor collected for tissue banking ** CONTINUED ON NEXT PAGE ** lw g/3 3
+
+--- Page 3 ---
+RUN DATE: PAGE 3 RUN TIME: RUN USER: (Continued) SPEC #: GROSS DESCRIPTION: (Continued) B3-B5 sections of tumor to deep margin B6 representative sections of upper outer quadrant. B7 representative sections of lower outer quadrant. B8 representative sections of upper inner quadrant (quadrant near tumor) B9 representative sections of lower inner quadrant sampled. INTRAOPERATIVE CONSULTATION: IMMEDIATE GROSS EVALUATION RIGHT BREAST: INVASIVE CARCINOMA. PROCESSED FOR TUMOR BANKING SURGICAL MARGINS FREE OF TUMOR PHOTO DOCUMENTATION Image Image Signed (signature on file) ** END OF REPORT **
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diff --git a/output/text/00ae28ec-fe97-47c3-8283-16c828c576b7.txt b/output/text/00ae28ec-fe97-47c3-8283-16c828c576b7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f85067a89368e12ceca793e4ca42f1f1aa593ed3
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+--- Page 1 ---
+page 1 / 1 Department of Cancer Pathology. Examination: Histopathological examination Internal invoice No. Cost of diagnostic procedure Examination No.: Patient: XXX PESEL: XXX Age: Gender: Material: 1. Multiple organ resection - sigmoid colon Unit in charge:  Physician in charge: Material collected on: Material received on Expected time of examination: Clinical diagnosis: Sigmoid colon with tumour Examination performed on: Macroscopic description: A 18.3 cm length of the large intestine with a piece of mesentery sized 19 x 9 x 4 cm. Tumour sized 5.6 x 6.3 x 1.7 found in the mucosa. The lesion surrounds 1o0% of the intestine circumference, is removed by 9.8 cm from the proximal incision line, and 7.2 cm from the distal incision line. Microscopic description: Adenocarcinoma tubulopapillare (GI).. Infiltratio carcinomatosa telae adiposae pericolicae.  Incision lines free of neoplastic lesions. Lymphonodulitis reactiva (NO viII).. Histopathological diagnosis: Adenocarcinoma tubulopapillare coli. Tubulopapillar adenocarcinoma of the colon. (GI, Dukes B, Astler - Coller B2, pT3, pNO). Compliance validated by: CONTACT YOUR DOCTOR WITH THIS REPORT!
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diff --git a/output/text/00b5b8bc-4d91-4e8c-925b-1c6c91430b13.txt b/output/text/00b5b8bc-4d91-4e8c-925b-1c6c91430b13.txt
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index 0000000000000000000000000000000000000000..18e14dfca8aaf3a316a8d3a551fba970566af5e8
--- /dev/null
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+
+--- Page 1 ---
+UUID:019F3900-7479-4CDC-8C82-45A27910E782 1cs-0-3 TCGA-A7-A0C-01A-PR Redacted Carcioma mfiltrstig oluct; Nos 850of3 SPECIMEN A. Left axillary sentinel lymph node B. Left breast biopsy. CLINICAL NOTES CLINICAL HISTORY: A -year-old white female with left breast cancer. FROZEN SECTION DIAGNOSIS AFs: Left axillary sentinel node, excision - One lymph node with no metastasis identified.. GrOss DEscRIpTIon A. Container A is labeled with the patient's name, medical record number and "left axillary sentinel node". The specimen consists of a single partially fatty replaced lymph node measuring 1.3 x 1 x 0.6 cm. AFs,bisected. B. Container B is labeled with the patient's name, medical record number and "left breast biopsy, long anterior, short superior." The specimen consists of a single piece of fibrous adipose tissue oriented by two sutures and measuring 6.5 cm in medial to lateral, 3.5 cm from superior to inferior and 3 cm from anterior to posterior. The specimen margins are inked as follows: Blue -- anterior; black -- posterior; yellow -- lateral; orange medial; red -- superior; green -- inferior. The specimen is serially sectioned. On cut section, there is a firm tan fibrotic-appearing tumor mass measuring 2.2 x 1.5 x 1.8 cm. The mass appears to extend to the posterior margin of resection. A portion is submitted for tissue procurement. The remainder of the tissue is submitted in blocks 1-15. MICROSCOPIC DESCRIPTION A. Sections of the left axillary sentinel lymph node demonstrate i lymph node with no evidence of metastasis. The lymph node was examined and multilevel sectioning with H&E stain as well as immunohistochemistry for pankeratin. B. The following template applies to the left breast biopsy: Invasive Carcinoma: Present. Histologic type: Infiltrating ductal carcinoma Histologic grade: Overall grade: 3 Architectural score: 3 Nuclear score: 3 Mitotic score: 2
+
+--- Page 2 ---
+Greatest dimension (pT): 2.2 cm. (pT2) Specimen margins: Positive. Invasive carcinoma extended to the green ink involving the. inferior margin. Vessel invasion: Not identified.. Calcification: Present Ductal carcinoma in situ: Present. Histologic pattern: Solid and cribriform. Nuclear grade: 2-3 Central necrosis: Focally present. *Dcis of total tumor: 25% Extensive intraductal component (present/absent): Present Specimen margins: Close. In situ carcinoma is less than 1 mm from the anterior, posterior, medial and inferior margins. Calcification: Present Description of non-tumorous breast: Proliferative changes.. Comments: None. MICROSCOPIC DESCRIPTION Prognostic markers:  Previously performed. 4x2, 20 DIAGNOSIS A. Left axillary sentinel lymph node, resection:. No evidence of metastasis in one lymph node (0/1).. B. Left breast, excisional biopsy:. Infiltrating ductal carcinoma, grade 3, 2.2 cm. extending to the inferior margin. Extensive ductal carcinoma in situ, solid and cribriforming. subtypes, nuclear grade 2-3, less than 1 mm from multiple margins. M.D, (Electronic Signature). - End Of Report
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diff --git a/output/text/00c0279c-c926-4899-909f-b1c77798e3fa.txt b/output/text/00c0279c-c926-4899-909f-b1c77798e3fa.txt
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index 0000000000000000000000000000000000000000..74df410743bce98f70f87f9b326b795a63a1e801
--- /dev/null
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+
+--- Page 1 ---
+with right colon mass and Specimens Submitted: I: Sp: Colon, right; hemicolectomy. DIAGNOSIS: 1. Sp: Colon, xight; hemicolectomy: Tumor Type: Adenocarcinoma Histologic Grade: Moderately differentiated Tumox Location: Ascending colon Tumor Size: Length is 5.5 cm width is 6.5 cm Tumor Budding: Absent Increased Tumor Infiltrating Lymphocytes: Absent Precursor Leslone: Not identified Deepest Tumor Invasion: Subserosal adipose tissue and/or mesentexic fat Gross Tumor Perforation: Not identified Lymphovascular Invasion: Identified Large Venous Invaslon: Not Identified Perineuxal Invasion: Not identified Surgical Margins: Free of tumor Polyps/Mucosa Dysplasia (away from the carcinoma): Tubular adenoma; number: 2 Hyperplastic polyp; number: 1 Non-Neoplastic Bowel: Unremarkable t* Continued on next page ** $
+
+--- Page 2 ---
+2 of 3 Appendix Fibrous obliteration of the lumen Lymph Nodes: Number with metastasis: 1 Total number examined: 24. Tumor deposits in pericolorectal soft tissue: Identieied Tumor Staging (Acc 7th Edition): pT3 (Tumor invades through the muscularis propria into pexicolorectal tissues) Lymph Node Stage (Awcc 7th Edition): N1 (Metastasig in 1-3 regional lymph nodes) PENDING K-RAS. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Result Special Stain Comment KRAS Gross Description: 1).The specimen is received freah, labeled "Right hemicolectomy colon' and consists of a segment of terminal ileun, cecum with attached appendix and. ascending colon. The terminal ileum measuxes 7.5 cm in length and 3.5 cm in circumference at the proximal resected margin.  The remaining colon measures. 19 in length with a circumference of 8 cm at the distal resected margin. The attached appendix measures 6.5 cm in length and averages 0.7 cm in. diameter. The appendiceal and intestinal serosa is pink tan and smooth.. Focally hemorrhagic lobulated yellow tan adipose tissue spans the length ot the specimen measuring up to 5' cm in thickness. The gpecimen is opened to. reveal a circumferential, centrally ulcerative, fungating, brown tan tumor measuring 5.5 cm in length, 6.5 cm in width, and 2.0 cm in height. On cut section of the tunox, it measures 2.5 cm in maximun depth and abuts the. black inked radial margin..  The tumor is located 6.3 cm from the ileocecal valve and 6 cm from the distal resected margin. Alao identified, 4.0 cm from. the ileocecal valve and 4.2 cm from the main tumor mass, there is a brown-tan polypoid structure measuring 1.8 x 0.8 x 0.7 cm.  The remaining mucosa shows brown-tan folded appearance and several polypoid areas measuring up to 0.4 x 0.3 cm in greatest dimensions, which are entirely Submitted. The apecimen is submitted fox lymph node dissection. The attached adipose tissue is thoroughly examined and all identified lymph nodes are aubmitted. Representative sections of the specimen are submitted. Continued on next page.
+
+--- Page 3 ---
+Pag Summary of sections: PM - proximal margin shave DM - distal margin shave T - tumor (box 11 and 12, 13 and 14 are full-thickness section of tumor with underlying cause of lymph node, bisected) APP - appendix representative sections RS -representative sectione LN - lymph nodes LPOL-largest polypoid area POL-polypoid areas Summary of Sections: Part 1: SP: Colon, right; hemic ectomy Block Sect. Site PCs app 2 m r dm LN 18 N m4 md mj 1po1 pm po1 1 rg 6 r ** End of Report ** $
+
+--- Page 4 ---
+Specimeng Submitted: 1: DM SUBMITTED 1O UNSTAINED SLIDES AND 1 H&E, RIGHT COLON Test Performed:. KRAs Gene Exon 2 mutation analyais (codons 12 and 13) DNA quality: good. Methodology: PCR was performed to amplify exon 2 of the KRAs gene from genomic DNA prepared from the submitted tigaue. The pcr product was analyzed on an ABI DIAGNOSTIC INTERPRETATION: Negative for KRAs exon 2 mutation.. Technical sensitivity: This asaay'cannot detect a xRAs exon 2 mutation if the proportion of tumor cells in the sample studied is less than 25%. 1. This result cannot be used as sole evidence for or against cancer and has to be interpreted in the context of all available clinical and pathological information. 2. This test was developed and its performance characteristics determined by the Laboratory of Diagnostic Molecular Pathology. It has not been cleared or approved by the. U.S. Food and Drug. Administration (Fba). The FDa has determined that such clearance is not necessary. This test is used for clinical purposes.. Pursuant to the requirements of CLia : 88,. oux laboratory has established the accuracy and precision of this test. This test has been approved by as a laboratory specific assay.. I ATTEST THAT THE ABOVE DIAGNOSTS IS BASED UPON MY PERSONAL EXAMINATION OF ** Continued on next page **.
+
+--- Page 5 ---
+Page 2 of 3 THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Procedures/Addenda Addendum Date Ordered:. Date Complete: Date Reported Addendum Diagnosis NONE OF THESE MOTATIONS WERE DETECTED IN THE TUMOR. CLINICAL PANEL Gene Codon BRAF V600 EGFR L858 INVESTIGATIONAL PANEL Gene Codon Gene Codon Gene Codon AKT1 E17 EGFR L861 NRAS G12 BRAF G469 ERBB2 L755 NRAS G13 BRAF D594 ERBB2 D769 NRAS Q61 EGFR E709 ERBB2 V777 PIK3CA R88 EGFR G719 KRAS Q61 PIK3CA N345 EGFR D761 KRAS K117 PIK3CA C420 EGFR S768 KRAS A146 PIK3CA E542 EGFR R776 MEKL Q56 PIK3CA E545 EGFR T790 MEK1 K57 PIK3CA M1043 EGFR T854 MEKL D67 PIK3CA H1047 Diagnoatic sensitivity: This finding does not exclude the poasibility of other mutations. Technical sensitivity: This test may not detect certain mutations if the proportion of tunor cells in the sample studied is less than 10%.. Test Performed:d Sequenom masa-spectrometry genotyping for specific mutations in 8 genes:. AKT1, BRAF, EGFR, ERBB2, KRAS, MEK1 (MAP2KI), NRAS, and PIK3CA Methodology: The specific mutations are detected by amplification of the corresponding. exons by polymerase chain reaction (pcr), followed by a single base. extension at the site of the point mutation. The single base extension product is detected by tandem mass-spectrometry on a Sequenom MassArray Spectrometer. Addendum Comment PLATE# P10-42 ** Continued on next page **
+
+--- Page 6 ---
+Page 3 of 3 This result cannot be used as sole evidence for or against cancer and has to be interpreted in the context of all available clinical and pathological. information. This test was developed, and ita performance characteristics detexmined, by. the It has not been cleared or approved by the U.S. Food and Drug Administration (FDA). The FDA has determined that such clearance is not necessary. This test is used for clinical purposes our laboratory has established the accuracy and precision of this test. The results of the inveetigational panel are for investigational use only.. ** End of Report **
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diff --git a/output/text/0101a550-8206-4187-8ee9-6bcbfb499b7e.txt b/output/text/0101a550-8206-4187-8ee9-6bcbfb499b7e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..03cef411752ce7723f3bd208e288624aea459d27
--- /dev/null
+++ b/output/text/0101a550-8206-4187-8ee9-6bcbfb499b7e.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+UUID:53881871-C36B-4622-BFC6-4DA363507B263 TCGA-AC-A7VB-01A-PR Redacted Referrinn Physician:. DOB: Age: Gender:F Ref#: Hoso#: Provider Group : Date of Service: Date Received: ase Date Reported: FINAL SURGICAL PATHOLOGy REPORT Diagnosis: A. - f. rIght breast And AxIlLary Lymph noDes, mastectomy, Sentinel LYMPH NODE BIOPSIES, AND AXILLARY LYMPH NODE DISSECTION: - Multifocal invasive ductal carcinoma, Nottingham grades 2-3. See comment. - Largest tumor nodule: 1.5 cm in diameter (6 o'clock aspect). - Two smaller nodules: 0.6 and 0.8 cm (7-8 o'clock aspect). - Ductal carcinoma in situ (DciS), high nuclear grade, solid type. - DCIS comprises less than 10% of biopsy tissue volume, and is associated with all three invasive tumor nodules. - Mastectomy margins are free of tumor.. - Carcinoma is 3 cm from the inferior margin and is at least 6 cm from all other margins.. - Metastatic carcinoma in three of fifteen lymph nodes (3/15). - Largest metastatic focus: 0.9 cm in diameter. - Extranodal extension present.. - Positive lymph nodes are sentinel lymph nodes #2, #3, and #4 PATHOLOGIC TUMOR STAGING SYNOPSIS: Type and grade (invasive): Invasive ductal carcinoma, Nottingham grade 2-3. Type and grade (in situ): Dcis, high-nuclear grade.. LQD o 3 Primary tumor: pT1c(m). Regional Iymph nodes: pN1c. 'arersmo,iryiltatiy oluct NoS Distant metastasis: Not applicable.. 8s00/3 Stage: IIA. Lymphovascular invasion: Indeterminate.. c 50.9 Margin status: Negative.. Q4I id/4ll3 COMMENT: The three foci of invasive carcinoma have similar histologic features, although the tumor grade is somewhat variable in the largest tumor nodule, where there is a variable rate of mitosis, and nuclear pleomorphism ranging from intermediate to high-grade. The smaller tumor nodules contain high-grade malignant Case #: Page 1 Printed: This report continues... (FiNAL) MR No. Acct No. - Patient Name  Pathology - Page 1/6. Page 1 Doc#1
+
+--- Page 2 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT epithelial cells arranged in solid sheets with frequent mitoses, compatible with Nottingham grade 3. There is enough morphologic similarity between three nodules to suggest that they have a common origin. Intradepartmental consultation: concurs with this impression. Invasive Breast Cancer Tumor Staging Information AJCC Cancer Staging Handbook, 7th Ed.. and CAP Protocol (revised June 2012). Previous pathology specimens: Page 2 Case #: 'his report continues... (FINAL) Printed: Patient Name - MR No. - 'age 2 Doc# 1 Pathology - Page 2/6
+
+--- Page 3 ---
+Patient: Case #: SPECIMEN IDENTIFICATION Procedure/specimen type: Modified radical mastectomy. Laterality: Right. Lymph node sampling: Sentinel lymph node biopsies followed by lymph node dissection. INVASIVE CARCINOMA TUMOR CHARACTERISTICS Histologic type: Invasive ductal carcinoma (multifocal). Tumor sites: 6:00-8:00. Tumor size: Largest tumor nodule 1.5 cm.. Tumor focality: Multifocal. Histologic grade (Nottingham Score): 2-3 of 3. Tubule formation: 3 of 3. Nuclear pleomorphism: 2-3 of 3. Mitotic rate: 2-3 of 3 (variable mitotic rate). Lymphovascular invasion: Indeterminate. Macroscopic and microscopic extent of tumor: No skin or chest wall invasion identified. DUCTAL CARCINOMA INSITU (DCIS): Present in association with three invasive tumor  nodules. MARGINS Invasive carcinoma: Negative. Ductal carcinoma in situ: Negative. LYMPH NODES Total lymph nodes examined 15. Number of lymph nodes involved 3. Size of largest metastatic deposit: 0.9 cm. Extranodal extension: Present. PATHOLOGIC STAGING: Primary Tumor (pT): pT1c(m). Regional lymph nodes (pN): pN1a. Distant metastasis (pM): Not applicable. AJCC Stage: IIA. ANCILLARY STUDIES: Performed by jn 2 previous biopsies (additional HER2 studies pending, to be reported in an addendum). Estrogen receptor: 85-96% positive cells, strong intensity. Progesterone receptor: 0% positive cells. HER2: Additional studies pending, to be reported in an addendum. Case # Page 3 Printed: This report continues... (FINAL) MR No. Acct No. . Patient Name - Pathology - Page 3/6 Page 3 Doc# 1
+
+--- Page 4 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT Variable, previously reported 7-69%. Ki-67: Source of Specimen: A. Sentinel lymph node;#1-- right axillary B. Sentinel lymph node;#2-- right axillary right axillary C. Sentinel lymph node;#3-- D. Sentinel lymph node;#4-- right axillary E. Breast surgical;right F. Axillary nodes right Clinical History/Operative Dx:. Right breast cancer. Intraoperative Diagnosis:. A. Sentinel node #1 - diagnosis: Negative for carcinoma. B. Sentinel node #2 - diagnosis: Rare atypical cells, suspicious for carcinoma. (Defer to. permanents). and  - diagnosis: Positive for carcinoma. D. Sentinel node #4 The intraoperative interpretation(s) was/were performed and rendered at. Gross Description:  right axilla, touch prep. Initially received in the fresh. A. Part A is designated as sentinel node #1 state four frozen section/touch prep evaluation is a 1.0 x 0.8 x 0.6 cm piece of red-tan soft tissue. Examination reveals a 0.7 x 0.6 x 0.5 cm lymph node. The cut surfaces are fatty and rubbery, pink and tan. Two touch imprint slides are prepared for microscopic evaluation. The lymph node is entirely. Page 4 Case #: This report continues... (FINAL) Printed: Acct No. : Patient Name - MR No. age 4 Doc# 1 Pathology - Page 4/6
+
+--- Page 5 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT submitted for routine histology in A1 with a sentinel node protocol performed. B. Part B is sentinel node #2 . Initially received in the fresh state for touch prep/frozen section evaluation is a 1.5 x 1.2 x 1. 0 cm yellow-tan portion of tissue. Examination reveals a 0.8 x 0.6 x 0.6 cm Iymph node. Sectioning demonstrates a rubbery, pink and tan cut surfaces. Two touch imprint slides are submitted for microscopic evaluation. The Iymph node is entirely submitted for routine histology in B1 with a sentinel node protocol performed. C. Part C designated as sentinel node #3. right axillary. Received in formalin is a 1.5 x 1.5 x 0.7 cm fragment of fat. Examination reveals two possible apparent lymph nodes, 0.8 x 0.6 x 0.4 cm each. The Iymph node is serially sectioned and entirely submitted for microscopic evaluation in C1 with a sentinel Iymph node protocol performed. D. Part D is designated as sentinel node #4 right axillary. Initially received in the fresh state for. frozen section/touch imprint evaluation is a 1.5 x 1.2 x 1.0 cm yellow-green portion of fatty soft tissue. representative section is submitted for frozen section evaluation. The residual frozen tissue is submitted in D1 for permanent sections and the touch imprint aspect of the lymph node is submitted in D2 for permanent sections with a sentinel lymph node protocol performed E. Received fresh labeled *right breast.* Sutures present for orientation purposes. A portion of tumor is submitted for Laterality: Right. Specimen: Mastectomy. Size of mastectomy: (M-L x S-I x A-P): 23.5 x 19 x 5 cm. Axillary tail: Not present. Skin: 24 x 18 cm, pigmented skin.Nipple/areola: Yes, center of skin. Specimen weight: 971 grams. Ink code: Blue -- superior-anterior, orange -- inferior-anterior, black - deep Slabs: Total # 11, M-1=1, L-S= 11. Nipple in slab #6. Time of resection: Time placed into formalin: Time out of formalin:. Lesion 1: Biopsy site present. Size: 1.5 x 1.4 x 0.8 cm, stellate, gray-white, firm mass. Location: 6:00. Involves slabs # 3-4. Distance to nearest margin(s): 3 cm from inferior margin, 6 cm from deep margin. Lesion #2: Biopsy site present. Size: 0.8 x 0.5 x 0.5 cm. Location: 7:00. Involves slabs #2-3. Distance to nearest margin(s): 6 cm from inferior. Case #: Page 5 Printed: This report continues... (FINAL) MR No. - Acct No. - Patient Name - Pathology - Page 5/6. - Page 5 Doc# 1
+
+--- Page 6 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT Lesion #3: No biopsy site present. Size: 0.6 x 0.6 x 0.5 cm. Location: 7:00. Involves slabs #4. Distance to nearest margin(s): 5 cm from inferior. Non-lesional breast: Fibrofatty breast tissue. Cassette summary:  E1) smallest 7:00 tumor, previously biopsied (portion of the small tumor submitted for E2-E4) largest 6:00 lesion, E5) central breast tissue, E6-E7) lateral breast tissue, E8) nipple/subareolar breast tissue, E9) representative breast tissue, E10-E11) fibrous tissue medial to largest tumor, E12) representative medial breast tissue, E13) mass #3, 7:00, E14-E15) central posterior breast tissue. F. Part F is which axillary nodes, right. Received in formalin is an 83 gram partially tattered portion of yellow-tan fatty soft tissue, 13.0 x 9.0 x 2.6 cm. Examination reveals eleven lymph nodes ranging from 0.2 cm to 1.9 x 1.4 x 1.2 cm in greatest dimension. The lymph nodes are entirely submitted for microscopic evaluation. Cassette summary: 4/28 F1) four lymph nodes,. F2) four lymph nodes,. F3) one lymph node, bisected, F4) one lymph node, bisected, F5-F6) largest lymph node, serially sectioned but Microscopic Description: A. - C. Immunohistochemical stain: CK OsCAR, showing focal metastatic carcinoma in specimens B and C. D. Immunohistochemical stain: CK OSCAR, highlighting metastatic carcinoma. HER2 - results pending, to be reported in an addendum. E. Immunohistochemical stain: HER2, to be reported in an addendum. F. Microscopic sections have been examined. The microscopic findings are retlected in the diagnosis rendered. Case #: Page 6 Printed: END OF REPORT (FINAL) MR No. - Acct No. 'atient Name - Pathology - Page 6/6 uge 6 Doc#1
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diff --git a/output/text/01192b42-c386-43af-961c-9d6b28670770.txt b/output/text/01192b42-c386-43af-961c-9d6b28670770.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a0763d8bd6ef0e476d28da61e2b8d05b7c0bb540
--- /dev/null
+++ b/output/text/01192b42-c386-43af-961c-9d6b28670770.txt
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+
+--- Page 1 ---
+Pathology Report. DIAGNOSIS (A) LEFT KIDNEY: CHROMOPHOBE RENAL CELL CARCINOMA, FUHRMAN'S NUCLEAR GRADE 3. (SEE COMMENT) TUMOR MEASURES 5.O CM IN MAXIMUM DIMENSION. FOCAL LYMPHATIC/VASCULAR INVASION IDENTIFIED.S Multilocular cyst. (4.0 cm) Margins of resection free of tumor.. COMMENT Immunoperoxidase studies demonstrate the tumor cells to be positive for CK7 and negative for CD10 and Vimentin, supporting the diagnosis of Chromophobe renal cell carcinoma. The tumor has a pushing border but does not invade the sinus adipose tissue or perinephric fat. The renal vein is free of tumor.. GROSS DESCRIPTION (A) LEFT KIDNEY - A nephrectomy specimen (15.0 x 10.0 x 8.0 cm) including the kidney (10.0 x 6.0 x 5.0 cm) and attached ureter (9.0 cm in length). Located in the mid-portion of the kidney there is a orange-brown homogeneous tumor measuring 5 x 4 x 4 cm. The tumor appears grossly to be confined to the kidney. No invasion of the renal vein is identified. Located in the inferior pole of the kidney (0.5 cm from the main mass) is a large multilocular cyst (4.0 x 3.0 x 3.0 cm) containing clear fluid. The cyst has a thin capsule and smooth lining.. SECTION CODE: A1, vascular and ureteric resection margin, en face;. A2-A7, tumor with adjacent kidney; A8, A9, tumor with adjacent renal sinus; A10-A14, renal cysts with adjacent renal parenchyma and small portion of tumor in cassette A10; A15, renal pelvis; A16, normal kidney.. SQ/msm CLINICAL HISTORY Left renal mass. SNOMED CODES
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diff --git a/output/text/0126a9bb-8172-4c8c-b333-4509fe5cddc5.txt b/output/text/0126a9bb-8172-4c8c-b333-4509fe5cddc5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e4ea7a1fa2151881060ec20321b81832b3443708
--- /dev/null
+++ b/output/text/0126a9bb-8172-4c8c-b333-4509fe5cddc5.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID: 5049C91E-F48B-4AA7-BE64-8371681893790 TCGA-OL-A5DA-01A-PR Reda Sample # LcD o-3 Carcinoma, Is bular inf, /traIn. FINAL PATHOLOGIC DIAGNOSIS 85q0/3 Sentinel node biopsy and partial mastectomy, S,te : Path-Brast UOQ A. Right axillary sentinel node: - Single lymph node, no tumor (0/1) C50.4 B. Right breast partial mastectomy: C$cF B Brash N6s - Invasive lobular carcinoma, SBR grade II, with focal necrosis. C 50.9 - Focal atypical ductal hyperplasia and atypical columnar cell change. - Uninvolved breast parenchyma with apocrine metaplasia. Breast Pathologic Parameters 1. Invasive carcinoma: A. Combined gross and microscopic measurement: 3.2cm B. Composite histologic (modified SBR) grade II - Architecture: 3 - Nuclear grade: 2 - Mitotic count: 1 C. Associated ductal carcinoma in situ (DCIS): Absent 2. Excisional biopsy margins: Free of tumor - Invasive carcinoma 1mm from superior (closest) margin (slide B14) - Additional margins greater than 2mm away 3. Blood vessel and lymphatic invasion: Absent 4. Axillary lymph nodes: Negative for tumor 5. Special studies (see - Expression of ER in 68% of invasive tumor nuclei - Expression of PR in 66% of invasive tumor nuclei - Her2/neu antigen (FISH): Non-amplified (ratio: 1) 6. pTNM: pT2, NO(sn), MX Clinical History: This patient is a.  -year-old female with a right breast mass. The patient self-palpated a breast mass in the right upper outer quadrant in  was sent for diagnostic mammography and ultrasound which revealed a worrisome mass approximately 2.5 cm in size. An ultrasound-guided core biopsy and clip placement was done. This was read as 3invasive mammary carcinoma with lobular features4 by The patient underwent a breast MRI on the which demonstrated an irregularly shaped, posteriorly positioned mass at 11 o'clock in the right breast measuring 4.5 x 2.5 cm. The
+
+--- Page 2 ---
+left breast and bilateral axillae were normal. The patient undergoes right sentinel lymph node biopsy and right breast partial mastectomy with needle localization. Comment The tumor cells are negative for E-cadherin consistent with a lobular phenotype. AE1/AE3 stain is negative on the sentinel node.. Specimens Received: A: Right axillary sentinel lymph node B: Right Breast Partial Mastectomy Gross Description: The specimen is received in two containers each labeled with the patient's name and medical record number. A. Part A is additionally designated 31 right axillary sentinel node #14. Received fresh for frozen diagnosis is a 0.9 x 0.7 x 0.6 cm lymph node which is bisected and entirely frozen and read as 3no evidence of metastatic tumor4 per The remnant of frozen tissue is entirely submitted in cassette A1FS. B. Part B is additionally designated 32. right breast partial mastectomy4. Received fresh on an AccuGrid with accompanying radiograph is a 185.5 gm partial mastectomy specimen. The specimen bears two needle localization wires and a double long stitch as well as double short stitch for orientation. The overall measurements are as follows: superior to inferior 9.8 cm, medial to lateral 9.5 cm, anterior to posterior 3.7 cm. The requisition designates the double long. stitch as lateral margin and short stitch as superior margin. The accompanying radiograph demonstrates an irregularly shaped stellate mass within the partial mastectomy specimen overlying quadrant C2, C3, D3 and D2. There is a needle localization wire which enters at A3 and terminates at E1. There is a second needle localization wire which enters A5 and terminates at E4. The mass is in between these two wires. Thereis a single clip in quadrant D2.. The specimen is inked as follows: anterior-black, posterior-red, lateral-violet. medial-yellow, superior-blue and inferior-green. The specimen is serially sectioned from lateral to medial into nine slices to demonstrate an irregularly shaped, firm, white-tan mass present in slices #4 through #8. Needle. localization wires terminate in slices #3 and #8. The clip is not identified
+
+--- Page 3 ---
+The dimensions of the mass are 2.8 x 2.4 x 1.5 cm. The mass is present 0.2 cm from the anterior margin, 2.7 cm from the inferior margin, 1.6 cm from the superior margin, and greater than 2 cm from both lateral and medial margins. The remainder of the specimen demonstrates grossly unremarkable breast parenchyma consisting of lobular, soft, yellow-tan tissue with intervening white fibrous septa. Representative sections are submitted as follows:. B1,B2: lateral margin, serially sectioned, entirely submitted B3,B4: medial margin, serially sectioned, entirely submitted. B5: closest approach of mass to anterior margin, slice #5 B6: closest approach to superior margin, slice #6. B7: closest approach of mass to inferior margin, slice #6 B8: mass, representative section slice #6. B9: additional representative section of mass, slice #7 B10: representative section of tissue at termination of localization wire, slice #3 B11,B12: tissue at needle localization wire termination, slice #8. B13,B14: representative sections of nodular tan-white breast parenchyma slice #9 B15,B16: representative sections of nodular tan-white breast parenchyma, slice #10 B17: representative section of unremarkable breast parenchyma, slice #8 B18: representative section of unremarkable breast parenchyma, slice #12 Intraoperative Consult Diagnosis: A1FS. Right axillary sentinel lymph node: No evidence of metastatic tumor.
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diff --git a/output/text/013643d8-723f-48a9-a315-0f7c6f766c58.txt b/output/text/013643d8-723f-48a9-a315-0f7c6f766c58.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4ea583b24c3bbb1efb5562c403993b75e8414329
--- /dev/null
+++ b/output/text/013643d8-723f-48a9-a315-0f7c6f766c58.txt
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+
+--- Page 1 ---
+/Cs 0-3 Sits: brust nos c50.9 8/74  Final Diagnosis Breast, right, excision: Infiltrating lobular carcinoma, Nottingham I (of III) forming a 1.6 x 1.5 x 1.3 cm mass (AJcc pTlc). The carcinoma shows ductular involvement. No angiolymphatic involvement is present. The surgical resection margins, including the separately submitted margins, are negative for tumor. Lymph nodes, right sentinel, excision: Negative for tumor. embedded sentinel lymph node tissue and confirms the H&E impression. The infiltrating breast carcinoma is positive for estrogen receptor and negative for progesterone receptor. UUID:95DC80AB-C070-4613-8C11-A124AEDF9754 TCGA-AR-A2LE-01A-PR Redacted
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diff --git a/output/text/0138414a-aa54-4ad7-813a-c01fae2abec9.txt b/output/text/0138414a-aa54-4ad7-813a-c01fae2abec9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ddac1ee8cf67b22e5e05412fac27fcd7fe75152d
--- /dev/null
+++ b/output/text/0138414a-aa54-4ad7-813a-c01fae2abec9.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+ FINAL DIAGNOSIS: TCGA-AZ-4682 Parts 1, 2 AND 3: SIGMOID COLON, COLECTOMY -- A.  INVASIVE MODERATELY DIFFERENTIATED ADENOCARCINOMA (3.0 CM) THROUGH MUSCULARIS Propria into.perirectal fat.  NO ANGIOLYMPHATICINVASION IDENTIFIED. C.  SURGICAL RESECTION MARGINS FREE OF TUMOR. D.  Three pericolonic Lymph nodes, free Of tumor (0/3). E. pATHOLOGIC STAGE pT3 N0 M1. HYPERPLASTIC.POLYPS. Part 4: Liver, biopsy -- MICROSCOPIC: SYNOPTIC DATA - PRIMARY COLON AND RECTAL TUMORS SPECImen TyPe: . Rectal/rectosigmoid colon (low anterior resection) SPECIMEN LENGTH: 32.0.cm : Rectosigmoid TuMOR SITE: TUMOR CONFIGURATION. Uicerating TUMOR SIZE: Greatest dimension: 3.0 cm INTACTNESS OF MESORECTUM:  Not applicable HISTOLOgIC TyPE: Adenocarcinoma HISTOLOGIC GRADE: .:. Low-grade (well to moderately differentiated) PATHOLOGIC STAGING (pTNM):. pT3 pN0 Number of nodes examined: 3 Number of nodes involved: 0 pM1 MARGINS: Proxima! margin uninvolved by invasive carcinoma Dista! margin uninvolved by invasive carcinoma Circumferential (radial) margin uninvolved by invasive carcinoma. Mesenteric margin cannot be assessed ANGIOLYMPHATIC INVASION: Absent PERINEURAL INVASION: Absent TUMORAL LYMPHOCYTIC RESPONSE: Mild to moderate Other polyps (type[s]):Hyperplastic polyps ADDITIONAL PATHOLOGIC FINDINGS:
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diff --git a/output/text/01461646-e769-4f18-a157-40560d7c327d.txt b/output/text/01461646-e769-4f18-a157-40560d7c327d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5851c62c5b92b3b0f04172227122d0a588836d56
--- /dev/null
+++ b/output/text/01461646-e769-4f18-a157-40560d7c327d.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+/es.0-3 Caucinome.mfi1tnsHny dutl, Nos 8500f3 Sr+ : buast, Nos C 50.9 3 page 1 / 1 Department of Cancer Pathologye copy No. Date: Examination: Histopathological examination. Internal invoice No. Cost of diagnostic proceduree Examination No.: Patient: XXX PESEL: XXX Age: Gender: F Material: Multiple organ resection -- left breast. Unit in charge:  Physician in charge: Material collected on: Material received on Expected time of examination: up to 8 working days. Clinical diagnosis: Examination performed or.. Results of immunohistochemical examination: No estrogen receptors found in the neoplastic cell nuclei. No progesterone receptors found in the neoplastic cell nuclei. HER2  protein stained with HercepTestTM by DAKo. Negative reaction in invasive cancerous cells (Score = 1+ ) Compliance validated by: Examination performed or Macroscopic description: Right breast sized 26 x 19 x 5 cm removed along with axillary tissues sized 10 x 8 x 2 cm and a skin flap of 27 x 11 cm. Tumour sized 2.1 x 2.2 x 0.8 cm on the border of the lower inner quadrants, placed 1.5 cm from the lower edge, 0.1 cm from the base. and 2.0 cm from the skin. Microscopic description: Carcinoma ductale invasivum NHG3 (3 + 3 + 2: 15 mitoses/10 HPF - visual area of 0.57 mm). Glandular tissue off the tumour showing lesions of the type mastopathia fibrosa et cystica, hyperplasia ductalis simplex (UDH). Axillary lymph nodes: Sinus histiocytosis lymphonodorum (No XI). Histopathological diagnosis: Carcinoma ductale invasivum mammae dextrae. Invasive ductal carcinoma of the right'breast. (NHG3, pT2, pN0). Compliance validated b CONTACT YOUR DOCTOR WITH THIS REPORT! UUID: 1560F753-D83A-4934-9618-1E18CE46C845 TCGA-D8-A13L-01A-PR Redacted 3f+r/x
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diff --git a/output/text/016d474a-b6f5-40ec-a9d4-f9345f170965.txt b/output/text/016d474a-b6f5-40ec-a9d4-f9345f170965.txt
new file mode 100644
index 0000000000000000000000000000000000000000..175d6be1fcc04bfb850a830854d04046a635007c
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+Department of Pathology UUID:FFA18E29-2CC3-48F3-A7F2-88FC092E5606 TCGA-P4-A5E7-01A-PR Redacted Tissue Source Site (TsS) #: Patholgy Accession No: Patient ID: Normal Sample ID: Pathology Report LCD-O-3 ******* MODIFIED REPORT - REVIEW ADDENDUM SECTION ****** COMMENT celi 8Q6c13 This addendum report is issued to comment on the type of papillary renal cell carcinoma,. as it was not mentioned in the original report. There is no other change in diagnosis. 8ite C64.9 After review of the H&E slides, this tumor is designated as type 2 papillary renal cell H1/io113 carcinoma. DIAGNOSIS (A) LEFT PARTIAL NEPHRECTOMY PAPILLARY RENAL CELL CARCINOMA, FUHRMAN'S NUCLEAR GRADE 3. TUMOR CONFINED TO KIDNEY. TUMOR MEASURES 4.5 CM IN MAXIMUM DIMENSION. Margins of resection free of tumor. (B) LEFT PARTIAL NEPHRECTOMY II: Renal parenchyma with focal glomerulosclerosis, no tumor present. (See comment) (C) ADRENAL BIOPSY: Adrenal cortical tissue. (See comment) COMMENT The specimen designated left partial nephrectomy (specimen B), consists of a fragment of renal parenchyma with focal glomerulosclerosis. Multiple additional deeper sections were examined.. The specimen designated adrenal biopsy (specimen C), consists of a fragment of adrenal cortical tissue. No metastatic carcinoma is identified. Correlation with the clinical findings is suggested. GROSS DESCRIPTION (A) LEFT PARTIAL NEPHRECTOMY - DEEP MARGIN - INK FROZEN SECTION INKED MARGIN - A partial nephrectomy specimen with attached perinephric fat (9.0 x 8.0 x 2.0 cm overall). The portion of kidney is approximately 5.0  5.0 x 2.0 cm and is marked with blue surgical ink along part of the parenchymal resection margin. A 4.5 x 4.0 x 1.9 cm friable orange-brown and focally hemorrhagic tumor mass is present within the kidney parenchyma. The tumor is less than 0.2 cm from the nearest parenchymal margin. No gross extension into perinephric fat is noted. The surrounding renal parenchyma is light tan and unremarkable. INK CODE: Black - parenchymal resection margin; blue - surgically marked parenchymal margin. SECTION CODE: A1, A2, frozen sections of parenchymal margin; A3-A6, tumor with margin; A7-A9, tumor with surrounding adipose and normal kidney; A10, tumor with blue surgical ink; A11-A16, additional tumor section. *FS/DX: REPRESENTATIVE MARGIN FREE OF TUMOR. (B) LEFT PARTIAL NEPHRECTOMY #2 - A 0.9 x 0.5 x 0.4 cm portion of renal parenchyma. The apparent cortical surface displays a 0.3 x 0.3 tan area of vague nodularity. The apparent parenchymal margin is tan and unremarkable. The cut surface does not show grossly invasive tumor.
+
+--- Page 2 ---
+Department of Pathology. Tissue Source Site (TSs) #: Patholgy Accession No: Patient ID: Normal Sample ID: Tumor Sample ID: INK CODE: Blue-apparent cortical surface, orange-apparent  parenchymal margin.e SECTION CODE: B, entire left partial nephrectomy. (C) ADRENAL BIOPSY, RULE OUT METASTASIS - A single portion of soft, yellow tissue (1.2 x 0.5 x 0.3 cm) is submitted entirely for frozen section in C. *FS/DX: ADRENAL CORTICAL TISSUE, NO METASTATIC CARCINOMA. CLINICAL HISTORYS None given. SNOMED CODES T-71000, M-Y7343 "'Some tests reported here may have been developed and performance. characteristics determined by . These tests have not been specifically cleared or approved by the U.S. Food and Drug Administration."
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diff --git a/output/text/0172007d-ca4b-473d-aef1-0373f8e18886.txt b/output/text/0172007d-ca4b-473d-aef1-0373f8e18886.txt
new file mode 100644
index 0000000000000000000000000000000000000000..cbfb8b619769d65007d780a7ffe89b44ea5ec553
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+SPECIMENS: A. RIGHT COLON AMENDMENT REASON This case was amended to correct a formatting error. No other changes were made to this report. SPECIMEN(S): A. RIGHT COLON GROSS DESCRIPTION: A. RIGHT COLON Received without fixative, labeled "right colon", is an ilealcolectomy specimen including one segment of. 6-cm long ileum, 3.5-cm cecum with attached 6-cm long appendix, 30-cm long colon, with attached mesenteric fat. The colon is approximately 3.5 cm in diameter. Both resection margins are stapled closed. After removal of the stapled line, the specimen is opened and reveals one polypoid ulcerated colonic lesion measures 2.2 x 1.5-cm and elevated above the colonic mucosa to 0.7 cm. This lesion is. 11-cm to the colonic resection margin and 19-cm to ileal resection margin. The lesion appears to be superficial and does not involve the colonic wall. Three additional polypoid areas are present and each measuring 1.2, 1.5 and 2-cm in greatest dimension and are located 3.5, 4.5, and 8.0-cm to the colonic resection margin. The uninvolved colonic mucosa and ileal mucosa are unremarkable. The appendix is. 6-cm in length and 0.5-cm in diameter and is grossly unremarkable. Multiple possible lymph nodes are. present in the mesentery fat. Representative sections are submitted as follows:. A1. Distal colonic resection margin A2. Proximal ileal resection margin A3-A4: Full thickness of ulcerated polypoid lesion with attached mesenteric fat (inked black), bisected A5. Additional section of ulcerated polypoid lesion A6. Sections from polypoid area, 8.0-cm to the colonic resection margin A7. Sections from polypoid area, 4.5-cm to the colonic resection margin A8. Sections from polypoid area, 3.5-cm to the colonic resection margin A9. Sections of ileum. A10. Sections of cecum and appendix A11. Ileocecal valve A12-A14: Random sections of uninvolved colon A15-A27: Multiple possible lymph nodes A28: Tip of appendix DIAGNOSIS: A. COLON AND TERMINAL ILEUM, RIGHT HEMICOLECTOMY:  INFILTRATING MODERATELY DIFFERENTIATED ADENOCARCINOMA ARISING IN A SERRATED ADENOMA (2.2-CM) - SURGICAL MARGINS ARE NOT INVOLVED  - METASTATIC CARCINOMA INVOLVING THREE LYMPH NODES (3/44) SYNOPTIC REPORT - COLON & RECTUM Specimens Involved Specimens: A: RIGHT COLON Specimen Type: Right hemicolectomy Tumor Site: Cecum Tumor Configuration: Exophytic (polypoid) Tumor size: 2.2cm Additional dimensions 1.5cm x 0.7cm WHO Classification Adenocarcinoma 8140/3 Histologic Grade: G2: Moderately differentiated Extent of Invasion: Muscularis propria Margins: Margin(s) uninvolved by invasive carcinoma (Proximal, Distal, Radial) Distance of invasive carcinoma from closest margin: 11cm Margin: distal Venous/Lymphatic Invasion: Absent
+
+--- Page 2 ---
+Perineural Invasion:  Absent Additional Pathologic Findings: three hyperplastic polyps Extent of Resection: R0: Complete resection with grossly and microscopically negative margins Lymph Nodes: Positive 3 / 44 Extranodal extension: Absent Implants: Absent Pathological Staging (pTNM): pT 2 N 1 M x Comment(s): The tumor has a minor mucinous component with occasional, rare signet ring cells present... Immunohistochemical studies were performed in blocks A3/A4-see below- to confirm presence of metastatic disease and assess depth of invasion. Further studies to assess microsatellite instability will. be reported as an addendum. SUMMARY OF IMMUNOHISTOCHEMISTRY/SPECIAL STAINS Material: Block A3 Population: Tumor Cells Stain/Marker:Result:Comment: CYTOKERATIN AE1/3 Positive Material: Block A4 Population: Tumor Cells Stain/Marker:Result: Comment: CYTOKERATIN AE1/3 Positive The interpretation of the above immunohistochemistry stain or stains is guided by published results in. the medical literature, provided package information from the manufacturer and by internal review of staining performance and assay validation within the Immunohistochemistry Laboratory of. The use of. one or more reagents in the above tests is regulated as an analyte specific reagent (AsR). These tests. were developed and their performance characteristic determined by the Department of Pathology Laboratory at. They have not been cleared or approved by the U.S. Food and Drug Administration.. The FDA has determined that such clearance or approval is not necessary. Special stains and/or immunohistochemical stains were performed with appropriately stained positive. and negative controls. CLINICAL HISTORY: None given PRE-OPERATIVE DIAGNOSIS: Colon cancer ADDENDUM: SUMMARY OF IMMUNOHISTOCHEMISTRY/SPECIAL STAINS Material: Specimen A Population: Tumor Cells
+
+--- Page 3 ---
+Stain/Marker:Result: Comment: MLH1 Positive MSH2 Positive PMS2 Negative MSH6 Positive The interpretation of the above immunohistochemistry stain or stains is guided by published results in the medical literature, provided package information from the manufacturer and by internal review of staining performance and assay validation within the Immunohistochemistry Laboratory of the. The use of one or more reagents in the above tests is regulated as an analyte specific reagent (ASR). These tests were developed and their performance characteristic determined by the Department of Pathology Laboratory. They have not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. Special stains and/or immunohistochemical stains were performed with appropriately stained positive and negative controls.  INTERPRETATION: No PMS2 proteins identified by immunohistochemistry. The results of microsatellite instability testing will be issued in a separate report.
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diff --git a/output/text/01844833-aa33-4549-948b-3a08a50f0a35.txt b/output/text/01844833-aa33-4549-948b-3a08a50f0a35.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0a3e5a68ef4104c6da1c3138898beda770363f7e
--- /dev/null
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+
+--- Page 1 ---
+P.15/33 SsiS; tAxiLLARY SENTIneL LympH NODe #1, BIOpSy - one lymph node with metastatic carcinoma measuring 1.5 mm in greatest Dimension (1/1).  NO exTracApsulAr ExTension Is identifieD. Part 2: Right sreast at 9 O'clock, segmental mastectomy . A.  mUL TIfOCAl JNyASIVe DUctAL CArciNQMA. nOTTInghAm GrADE 2 (nUCLEAr GrADe 3, TUBULE Score 3, mitotic activity score 1. total 8core 7/9). e.  mAIn TUmOR MASs MEAsURe8 2.2 Cm AND iS ASSOciATed WITh BIOPSy SITe CHAnGES. C. A 2.S MM SATELLITE nODUEE OF INVASIVE TUMOR IS PRESENT NEAR THE LATERAL ASPECT OF THE Specimen, Away from the main tumor mass. D. THiro tumOR FOcUS iS SEen in PaRT 3 (soc comment). E. LYMPHOVASCULAR SPACE INVASION IS IOENTIFIED. F.  PERINEURAL INVASION IS.IDENTIFIED. G. TUMOR NODULES.CONTAIN CENTRAL FIBROSIS WITH PSEUDO DECiDUALIZEd STROmAL HYPERPI.ASIA (pash) LiKe StrOmal ReactiOn. H. DuctaL CARcInOmA In SiTU (DCIS). nUcLEAR GrADe 3 wITh COmEDOnecROSiS And CALCIFICATIONS:  MARGINS ARE NEGATIVE FOR NEOPLASM (INCLUDING BOTH TUMORS IN PART 1); INVASIVE CARCINOMA WAS CLOSEST TO THE ANTERIOR MARGiN (3 mM) AND INTRAVASCULAR TUmOR WAS CLOSEST TO THE SUPERIOR MARGIN (2 Mm). Changes consIstent with previous BiOp8y Site. K. tUmOr PreViOUsLy repORted tO BE POsITiVE fOR eR AnD PR, AnD nEgAtIVe fOr hEr-2/nEu PATHOLOGIC 8TAGE: pT2 pN2a pMX. Part 3: Right axillary contents, Di8section : A. Satellite.noDule Of invasive ductal Carcinoma And Ductal Carcinoma In Situ .  SimILAR in APPEArAnCe tO TUmOR SEen In PArt 2 (9.5 mm). B.  SEVEN LYMPH NODES, POSITIVEFOR METASTATIC AOENOCARCINOMA MEASURING UP TO AppROXImATELY 6 Mm EACH (7/13). C. ExtracapsuLar Ex'tensIonis Present and measures Less thAn 1 mm. D. EXTeNSIVe intRAVASCULAK iumUR. CASE SYNOPSIS: 1cs-o-3  SYNOPTIC - PRIMARY iNVASIVE CARCINOMA OF BREASt LATERALITY: Cnicii oms, nifilr#ny ductl,Nts 85oo/3 PROCEDURE: Right  Sagmental Si#:buust, Nos C5v.9 3/131n d- LOCATION: Uppur nuter quadrant SIZE OF TumOR: Lower outor quadrant MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: Maxirmiurn Qimcnsion invasive componcnt: 2.2 cm Tumor Aggregate size: Yes TUmOR TYPE (invasive component): Sum of the sizos of multiple invasive tumors: 3.4 cm NOTTINGHAM SCORE: Ductal adenocarcinoma, NOS Nuclear grade: 3 Tubulo formatlon: 3 Total Nottinyham srnre: 7 UUID:E4CBDC29-63E2-4CF0-B02F-16CA9C69F26E ANGIOLYMPHATIC INVASION: Nottinyham grade (1, 2. 3): 2 TCGA-BH-A0DS-01A-PR DERMAL LYMPhATIC INVASION: Yes Redacted CALCIFICATION: Not applicahlc Tumor type, in situ: Yes, malignant zones Cribriform SURGICAL mARGINS INVOLVED BY INVASIVE COMPONENT: Comedo No SURG MARGINS INVOLVED BY IN SITU COMPONENT: Distance of invasive tumor lo closest maryin: 2 mm No LYMPH NODES POSITIVE: Diytance of in situ discaxe to dosest margin: 6 mm LymPh nODeS ExAMINED: B METHOD(S) OF LYMPH NODE EXAMINATION: 14 Sentinel nOde metAstasis: H/E stain  SIZE OF NODAL METASTASES: Yes Lymph nOde metA8tASis(-es) wiTh ExtracapsuLAR ExTensiOn: Diameter of largest lymph node metastasis: 6 mm t stage, Pathologic: Ycs N Stage. pathologIC: pT2 m stage, pathologic: pN2a ESTROGeN RECEPTOrS: pMX PROGeSTERONe RecEptORS: posilive HER2/NEU: positivn rimary Tum HPAA Disc Zoro ur 1+ rior Malignan sual/Synch se is{Li 33
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diff --git a/output/text/0184b3ab-2ef7-44aa-98d0-260dc7657ac2.txt b/output/text/0184b3ab-2ef7-44aa-98d0-260dc7657ac2.txt
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index 0000000000000000000000000000000000000000..322637acef23a2dcef28d7dae07cb5c422819eee
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+--- Page 1 ---
+1cs-0-3 CaLcinvma, metap|asft,N0s 8575f3 UUID:46A75AD3-BAD1-4A16-873E-0099BD10FA8C Sit; srnst, NOS TCGA-A7-A26F-01A-PR Redacted C 50.9 4/27/11 DEPARTMENT OF PATHOLOGY AND LABORATORY MEDICINE Date Coll SPECIMEN A. Left axillary sentinel lymph node B. Left breast CLINICAL NOTES CLINICAL HISTORY: A -year-old with left breast metaplastic cancer. FROZEN SECTION DIAGNOSIS AFs Left axillary sentinel node, excision: No evidence of metastasis in 1 node (0/1) GROSS DESCRIPTION A. Received in a container labeled with the patient's name, medical record number and "left axillary sentinel lymph node". The specimen container holds a single soft tan lymph node measuring 1.5 x 1 x 0.5 cm. AS block Asf, bisected. B. Container B is labeled with the patient's name, medical record number and "left breast". The specimen consists of an excisional biopsy oriented by two sutures and measuring 3.5 cm. from anterior to posterior, 3.8 cm. from superior to inferior and 2.5 cm. from medial to lateral. The specimen margins are inked as follows: blue-interior, black-posterior, red-superior, green-inferior, yellow-medial, orange-lateral. serially sectioned and there is a firm, tan stellate lesion The specimen is measuring 1.8 x 1.5 x 1.5 cm., located extending in the direction of the inferior margin of resection and appearing to involve the inferior margin. Asb1-b20. MICROSCOPIC DESCRIPTION A. There is no evidence of metastasis in one left axillary sentinel lymph node. The node is examined by multilevel sectioning with H&E staining, as well as for immunohistochemistry for pankeratin. B. Invasive Carcinoma: Present. Histologic type: metaplastic. Histologic grade: Overall grade: 3 Architectural score: Nuclear score: 3 Mitotic score: 3 Greatest dimension (pT): 1.8 cm (pT1) Specimen margins: Positive. Vessel invasion:  Invasive carcinoma involves inferior margin over a distance of greater than 1 cm. Vessel invasion: foci suspicious. Calcification: Present. Ductal carcinoma in situ: Present. Histologic pattern:  Solid. Nuclear grade: 3 Central necrosis: Present.
+
+--- Page 2 ---
+% Dcis subtotal tumor: Less than 10%.. Absent. Extensive intraductal component:. Specimen margins: Negative. Calcification: Present. Description of non-tumorous breast:. Unremarkable. Comments: None. Previously FISh for HER-2 was reported as Prognostic markers: equivocal and a block is sent at the request of. repeat HER-2 by FISH. DIAGNOSISS Left axillary sentinel lymph node, resection: A. B. Left breast, excisional biopsy:. Poorly differentiated carcinoma with metaplastic features, grade 3, 1.8 cm Invasive carcinoma extends to involve the inferior margin of resection.  Ductal carcinoma in situ, solid and comedo subtypes,. nuclear grade 3 with necrosis, margins negative.. ctronic Signature) -End Of Report Case is (circie)
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diff --git a/output/text/01ada9fd-11b3-4b62-bf75-7bf4c71f81a9.txt b/output/text/01ada9fd-11b3-4b62-bf75-7bf4c71f81a9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4274e03a3b2540fd8f62ddf539eb2021d9375eec
--- /dev/null
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+
+--- Page 1 ---
+Clinical Diagnosis & History: Right renal mass. Specimens Submitted: 1:SP:Right kidney,ureter and bladder cuff nephrouterectomy 2:SP:Retroperitoneal lipoma,rightexcision 3:SP:Lymph nodes.paracavalexcision 4:SP:Lymph nodes,right common iliacexcision 5:SP:Lymph nodes,precaval and interaortocavalexcision 6:SP:Lymph nodes, suprahilar,and adrenal gland,right excision DIAGNOSIS: SP:Right kidney,ureter and bladder cuff; nephrouterectomy Tumor Type: Renal cell carcinoma-Chromophobe type Tumor Size: Greatest diameter is 3.2 cm. Local Invasion (for renal cortical types): Involves renal sinus fat Renal Vein Invasion: Not identified Small vessel angiolymphatic invasion is also not identified Surgical Margins: Free of tumor Non-Neoplastic Kidney: Mild arteriosclerotic changes and benign cortical cysts Adrenal Gland Not identified Lymph Nodes: Not identified Staging for renal cell carcinoma/oncocytoma: pT3a Tumor invades the adrenal gland or perinephric tissues but not beyond Gerota's fascia Comment:Benign pelvi-calyceal system and ureter 2.SP:Soft tissue, retroperitoneumright;excision Mature adipose tissue,4.6cm. Page 1 of4
+
+--- Page 2 ---
+SURGICAL PATHOLOGYREPORT No atypia identified. Comment: This part of the specimen was seen in consultation with who concurs. 3. SPLymph nodes,paracaval;excision Lymph Nodes: Not involved Number of nodes examined:4 4. SP:Lymph nodes,right common iliac;excision Lymph Nodes: Not involved Number of nodes examined:2 5.SP:Lymph nodes,precaval and interaortocaval; excision Lymph Nodes Not involved Number of nodes examined:7 6.SP:Suprahilar nodes and right adrenalgland;excision Benign adrenal gland. No lymph nodes identified. IATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL).AND THAT IHAVE REVIEWEDANDAPPROVEDTHISREPORT. Special Studies: Result SpecialStain Comment RECUT RECUT RECUT Gross Description: 1).The specimen is received in fresh state for intraoperative consultation, labeled as"right kidney,ureter, and bladder cuffand it consists of a total nephrectomy specimen weighing in total 502 g.The specimen surface is inked.No adrenal gland is identified. Kidney measures 11x 6.0 x 3.9 cm,and the segment of ureter measures 19 cm in length and 0.8 cm in circumference.The distal end of the ureter may actually represent "bladder cuff.Sectioning reveals a well-circumscribed brown soft cortical mass measuring 3.2 x 3.2 x2.9 cm in the lower medial aspect of the specimen.The majority of the tumor is in close contact with sinus fat, but frank invasion is grossly not identified. Grossly evident venous invasion is not seen. Perirenal fat is uninvolved. Background renal parenchyma shows mildly thinned cortex (0.7 cm) with sharp cortical medullary junction. Pelvic mucosa and ureteral mucosa appears grossly unremarkable.No possible lymph nodes are identified in the perirenal fat.The specimen is photographed. TPS is taken. Summary of sections: FSC--frozen section control tumor) UM- ureter margin Page 2of4
+
+--- Page 3 ---
+SURGICAL PATHOLOGY REPORT VM--vascular margins TSF-tumor with sinus fat T-tumor BG--background renal parenchyma P--pelvic mucosa U--ureteral mucosa 2).The specimen is received in formalin, labeled as" right retroperitoneal lipoma",and it consists of a partially encapsulated nodule of adipose tissue measuring 4.6 x 2.3 x2.0 cm.Sectioning reveals grossly unremarkable adipose tissue without fibrosis or hemorrhage. Representative sections are submitted. Summary of sections: U--undesignated 3).The specimen is received in formalin,labeled as paracaval lymph nodes",and it consists of multiple possible lymph nodes measuring up to 1.0 cm.Entire lymph nodes are submitted. Summary of sections: LN-- lymph nodes 4). The specimen is received in formalin, labeled as "right common iliac lymph nodes",and it consists of a single possible lymph node measuring 0.6 cm.Entire lymph node is submitted Summary of sections LN-- lymph node Akihiko Yoshida,M.D. 5).The specimen is received in formalin, labeled as precaval and inter-aortocaval lymph node",and it consists of multiple possible lymph nodes measuring up to 3.5 cm.The largest lymph node is trisected. Entire lymph nodes are submitted. Summary of sections: TLN--trisected lymph node LN--lymph nodes Akihiko Yoshida,M.D 6).The specimen is received in formalin, labeled as "suprahilar nodes and right adrenal gland",and it consists of an adrenal gland and surrounding adipose tissue.Adrenal gland measures 7.0 x 3.5 x 1.6 cm and weighs 10.5 g after the removal of fat. Section reveals grossly unremarkable adrenal tissue. Surrounding adipose tissue does not contain grossly evident lymph nodes. Representative sections are submitted. Summary of sections: AD--adrenal F-adipose tissue, slightly fibrotic area Summary of Sections: Part 1:SP:Right kidney, ureter and bladder cuff; nephrouterectomy Block Sect.Site PCs 2 bg 2 1 fsc 1 1 1 1 1 6 tsf 6 1 u 1 1 um 1 Page3of4
+
+--- Page 4 ---
+SURGICAL PATHOLOGY REPORT 1 vm 1 Part 2:SP:Retroperitoneal lipoma,rightexcision Block Sect.Site PCs 5 u 5 Part 3:SP:Lymph nodes,paracaval;excision Block Sect.Site PCs 1 In 1 Part 4: SP:Lymph nodes,right common iliac;excision Block Sect. Site PCs 1 In 1 Part 5: SP:Lymph nodes,precaval and interaortocaval;excision Block Sect. Site PCs 1 In 1 2 tIn 2 Part 6: SP:Lymph nodes,suprahilar,and adrenal gland,rightexcision Block Sect.Site PCs 1 ad 1 1 f 1 Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. FROZEN SECTION DIAGNOSIS:SP:Right kidney,ureter and bladder cuff RENAL CORTICAL NEOPLASM. PERMANENT DIAGNOSIS: SAME Page4of4 END OFREPORT
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diff --git a/output/text/02146566-abfa-4a87-87f2-6c4d31476112.txt b/output/text/02146566-abfa-4a87-87f2-6c4d31476112.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a634e194d9360f12a21d7773c0e9f9613c0e5d0d
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+
+--- Page 1 ---
+Diagnosis: Colon resection material 8 cm in length includes an extensively ulcerated, colorectal type of adenocarcinoma of almost circular growth extending 3 cm lengthwise and situated in the center of the preparation with infiltration of the pericolic fatty tissue and five regional lymph node metastases. No evidence of penetration of the overlying serosa. Tumor-free colon resection margins. Tumor stage: pT3 pN2 (5/12) pM1 (clinical liver metastases); G2, L1, V0, locally R0). 2.: Inflammation-free small intestine or Meckel's diverticulum without evidence of tissue heterotopy.
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diff --git a/output/text/021b8210-f84c-4b50-b063-db9b5a0d4455.txt b/output/text/021b8210-f84c-4b50-b063-db9b5a0d4455.txt
new file mode 100644
index 0000000000000000000000000000000000000000..bd7ae233e14ef4310aca62c0c95c7fe46a3b6f4f
--- /dev/null
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+
+--- Page 1 ---
+UUID:7BA4658F-3343-4176-BDCD-620A1001A032 TCGA-D8-A73U-01A-PR Redacted Patient: XXX Age: Gender: F Unit in charge: orcnoind, syyistiativg lsbulor  Physician in charge: $52013 Clinical diagnosis (suspicion) Cancer of the left breast Nos Date of admission: S C5b.9 10/s/3 Material: 1) Material: Left breast. Method of collection: total organ resection. Histopathological diagnosis: Examination performed on:  Invasive lobular carcinoma of the left breast (NHG2, pT2). (8520/3 T-34030)* * codes according to ICD-O-3 or SNOMED Macroscopic description: Left breast, sized 21.2 x 12.3 x 5.4 cm, removed without axillary tissues and with a skin flap of 18.2 x 8.3 cm. Weight: 436g. Tumour sized 4x2,2x1,6cm found on the boundary of upper quadrants, placed 2.8 cm from the upper boundary, 1.4cm from the base and 1.0cm from the skin.. Microscopic description: Invasive ductal carcinoma (classical type) -- NHG 2 (3+2+1: 0 mitoses/ 10 HPF -- visual area: 0.55mm: 0.55mm). The  nipple without pathological lesions. Glandular tissue showing parenchyma atrophy. Assistant: Pathologist: Edited by Results of intraoperative examination:. Examination performed on:. Estrogen receptors found in 75% of neoplastic cell nuclei. Progesterone receptors found in 75% of neoplastic cell nuclei. HER2 protein stained with. HER-2/neu (4B5) Rabbit Monoclonal Antibody. Negative reaction in invasive cancerous cells ( Score = 1+). The expression of proliferating nuclear antigen Ki 67 in 15 % cellular nuclei.. Assistant: Pathologist: Edited by CONTACT YOUR DOCTOR WITH THIS REPORT! i.8/ rmary Tun
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diff --git a/output/text/022f3875-76eb-499f-b2a6-af2649ad405b.txt b/output/text/022f3875-76eb-499f-b2a6-af2649ad405b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5184ec71ebde03538b3a35d7f151cfbef9e21722
--- /dev/null
+++ b/output/text/022f3875-76eb-499f-b2a6-af2649ad405b.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+SPECIMEN A. Sigmoid colon, upper rectum and adherent posterior bladder wall and small intestines B. Appendix CLINICAL NOTES PRE-OP DIAGNOSIS: Rectal cancer. GROSS DESCRIPTION A. Received fresh subsequently fixed in formalin labeled "sigmoid, upper rectum with adherent posterior bladder. wall and small intestines". The specimen consists of a rectosigmoid colon with adherent portions of small bowel and possible portion of. bladder. A segment of small bowel was 12 cm long, stapled at both ends, which are arbitrarily inked blue and black. A portion of colon is 46 cm long. Both ends are stapled, inked blue and the. opposite is opened and is inked black. There is also a small portion of possible bladder, which is 7 x 5 cm. This is smooth to slightly velvety and the margin of this is inked blue. Orientation. cannot be determined.  One end away from the tumor is inked blue. The opposite end close to the tumor is inked black. The specimen is opened to show a large fungating mass, which is 12 x 11.5 x 3.5 cm. This comes within 2.5 cm of the black inked margin. This tumor is centrally necrotic and goes through the wall of the colon, into the. surrounding fat and through the wall of the small bowel into the mucosa of the small bowel. The remainder of the mucosa of small bowel is pink-tan smooth glistening with normal slightly dilated poles having an average circumference of 6.5 cm and the mucosal alteration of tumor is 3.5 x 3.5 cm. This comes within equidistant luminal margins of the small bowel. The tumor also comes through the wall into the fat and possibly involves the mucosa of the portion of bladder. This is velvety, coming within 0.5 cm of the nearest peripheral margin. The remainder of the mucosa of the specimen is pink-tan smooth glistening with an average. circumference of 9.5 cm. The tumor comes within 1.5 cm of being circumferential and shows a markedly necrotic central focus. Lymph nodes are grossly identified. Representative sections of the specimen are submitted as follows: BLOCK SUMMARY: 1 - Representative luminal margins of small bowel,. 2  representative section of small bowel tumor, 3-4 - representative section of bladder to tumor, 5 - representative luminal margins of. the colon, 6 - representative section of tumor to normal, 7 and 8. representative sections of tumor to fat, 9-12 - have six possible
+
+--- Page 2 ---
+lymph nodes have four possible lymph nodes each. RS-15. B. Received in formalin labelled "appendix" is a 6.3 x 0.7 cm appendix which is partially covered with pink-tan smooth glistening serosa and yellow lobular fat.  The specimen is sectioned to show an intact wall with. an average thickness of 0.4 cm. The lumen ranges from pinpoint to 0.4 cm and shows possible diverticula present. No other discrete gross lesions are identified. The entire specimen with the exception of the fat is. submitted in t settes. As-2 (fat retained), proximal end. inked. As-2. MICROSCOPIC DESCRIPTION A. Microscopic exam of the resection shows:. Histologic type: Adenocarcinoma, not otherwise specified Histologic grade: Moderately differentiated. Primary tumor(pT): Tumor invades through the entire colonic wall and through the entire adhesed small intestinal wall into the lumen of the small intestine. The tumor also invades into the muscularis propria of the bladder wall (pT4b).. Proximal margin: Negative for tumor.. Distal margin: Negative for tumor.. Circumferential (radial) margin: Negative for tumor although not truly applicable given the resection of the adhered additional Organs. Distance of tumor from closest margin: 2.5 from one of the colonic margins Vascular invasion: Not identified. Regional lymph nodes (pN): 30 lymph nodes are dissected from the specimen and they are all negative for metastatic (pno). Non-lymph node pericolonic tumor: Present in the soft tissue adhesing the small intestine and the bladder to the upper rectal/sigmoid colon resection. No discrete additional nodules of
+
+--- Page 3 ---
+pericolonic tumor seen. Distant metastasis (pM): Cannot evaluate pMx. Other findings: There is significant necrosis of the tumor in the central areas. B. Microscopic examination of the appendix reveals a benign mucocele at the tip. No dysplasia or malignancy is identified. There is focal fibrous obliteration of the tip. including obliteration of the diverticulum. There is acute serositis and ahdesions. 5x1, 2x1, 3260F DIAGNOSIS A. Sigmoid colon, upper rectum and adherent posterior bladder wall and small intestines, resection: Invasive moderately differentiated adenocarcinoma. Tumor invades through the entire colonic wall and through the. entire adhesed small intestinal wall into the mucosa of the. small intestine. Tumor invades into the muscularis propria. of the bladder (pT4b). Thirty lymph nodes are negative for metastatic tumor (0/30). (pNO). Resection margins are negative for tumor. B. Appendix, excision: Hyperplastic mucinous epithelium consistent with benign mucocele. . Resection margins are negative. Serosal adhesions. --- End Of Report ---
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diff --git a/output/text/024b6882-c066-47f7-a221-741b7a1ba992.txt b/output/text/024b6882-c066-47f7-a221-741b7a1ba992.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8cd1396b4c4ee0de346d66184e128baf9ea4a2b9
--- /dev/null
+++ b/output/text/024b6882-c066-47f7-a221-741b7a1ba992.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+/cs-0-3 8500/3 Carcinoma, mifiltrstny duct, N0s Site : srsst, nos c50. 9 4/20 OC#:. TSS #: Procurement Date: Laterality:Right, upper inner quadrant Path RepOrt:BREAST TISSUE CHECKLiST Specimen type: Lumpectomy Specimen size: Not specified Tumor site: Breast Tumor size: 1.5 x 0 x 2 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinoma Histologic grade: Poorly differentiated Tumor extent: Not specified Lymph nodes: 0/10 positive for metastasis (Axillary 0/10) Extracapsular invasion of the lymph nodes: Not specified Margins: Uninvolved Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified UUID:742A4812-9EB1-4348-996E-3F1AD7FA3E5D Comments: None TCGA-E9-A243-01A-PR Redacted
\ No newline at end of file
diff --git a/output/text/024ea4e3-9b76-407f-81e1-14b2192bdf51.txt b/output/text/024ea4e3-9b76-407f-81e1-14b2192bdf51.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d2f19dd84fb9d6e5589f41fced2b3b7e4f4ce5a5
--- /dev/null
+++ b/output/text/024ea4e3-9b76-407f-81e1-14b2192bdf51.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Patient Name Accession #: Med. Rec. #: Date of Procedure DO8. Date of Receipt Gendor: Date of Report: Ret. Physician: Account #f. Patient Address: Billing Type. Additional Copy to. Ref. Source: Clinical Diagnosis & History: Right renal mass. Specimens Submitted: 1: SP: Kidney, right, partial nephrecton 2: SP:Kidney, Deep surgical margin #2. DIAGNOSIS: 1 SP: Kidney, right, partial nephrectomy(fs)(am): Tunor Type: Renal cell carcinoma - Unclassitied type The tunor has papillary. tubular, and solid foaturos.High grade. Tumor Size Greatest diameter is 1 6 cm Local Invasion (lor renal corlical typos): Involves ronal sinus fatd Renal Vein Invasion: Not idontified Surgical Margins: Free of tumor Non-Neoplaslic Kidney:. Unremarkable Adrenal Gland: Not identified Lymph Nodos: Not identified Staging for renal cell carcinoa/oncocytoma pT3 Tumor extends into major voins or invades the adrenal gland or pornephric tissues, but not boyond  fascia Comment: While this tumor does not fit into one of our well described entities, I favor it being ol distal nephron origin 2."Deep surgical margin#2",  excision: Benign renal parenchyma. No tunor idontified. Page 1 of 3
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT TATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWEDANDAPPROVEDTHISREPORT Special Studies:. Rosull Special Stain Comment CA-1X. NEG CONT IMM RECUT RECUT RECUT RECUT CK7 RACEMASE MIB-1 (Ki-67) Gross Description. ed "right renal tumor.It consists of a 2.8 x 2.8 x 2.5 cm wedge shapod portion of kidney with a suture marking the deep margin. The margin is inked black and the margin at stitch pink -yellow. The specimen is serialy seclioned to reveai white yellow mass measuring 1.6 X 1.5 X 1.1 cm. The tumor from the resection margin (with stitch. yellow ink) is 0.3 cm and within 0.1 cm to the closest the black inked margin.  A representative section of the nearest margin is submitted for frozen section diagnosis. Representalively submitted. Portions of the tumor are submilled for TPS. Summary of sections:. FSC - frozen seclion control. T - tumor M - margin RS - representalive sections. 2).The specimen is received in formalin. labeled "Deep surgical margin number two" and consists of a 0.7 x 0.6 x 0 3 cm fragment of tan soft tissue. Entirely submitted. Summary of sections: U - undosignaled. Summary of Sections:. Part 1: SP: Kidney, right, partial nephrectomy Block Sect. Site PCs fsc 1 1 m 1 2 rs 2 1 1 Part 2: SP:Kidney, Deop surgical margin #2, excisio Block pCs Sect. Site 1 u 1 Intraoperative Consultation:d Nole: The diagnoses given in this section pertain only to the tissue sample examined at the lime of the intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS: MARGIN AT STITCH IS BENIGN. CARCINOMA, NOT CLEAR CELL Page 2 of 3
+
+--- Page 3 ---
+PERMANENT DIAGNOSIS Page 3 of 3 END OF REPORT
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diff --git a/output/text/02697be0-5c89-46f1-acf6-e143b5a31906.txt b/output/text/02697be0-5c89-46f1-acf6-e143b5a31906.txt
new file mode 100644
index 0000000000000000000000000000000000000000..833742ebcce219024e30d28b6016a10c91a98912
--- /dev/null
+++ b/output/text/02697be0-5c89-46f1-acf6-e143b5a31906.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TCGA-AN-A0XR-01A-PR Redacted TSS Patient ID Case #: DOB: Sex: Female Ethnicity (Race): Cancer Sample  Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma Date of Procurement:. Anatomic Site: Breast Tumor location: Primary Tissue Specification: Tumor Specimen Matrix: Tissue Specimen Format: OCT Container: block Type of Procurement: surgery Grade: 2 T Stage: 2 N Stage: 2b M Stage: 0 Treatnent: none Treatment Details: n/a. Norma! Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw Matrix: Blood Specimen Format: frozen Container: tube Date of Procurement: 1cs-0 -3 csrcinwma infiIt^eAny ctuct; Nos 85oc/3 Site: breast, Nos. C50.? hu 10 /21/ 1/8+f1t
\ No newline at end of file
diff --git a/output/text/026bb285-537e-4a6f-96d9-9f9ec8fa45e0.txt b/output/text/026bb285-537e-4a6f-96d9-9f9ec8fa45e0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2fdc3fe68c040cfbc09fa7eda9c6007a9d0124ad
--- /dev/null
+++ b/output/text/026bb285-537e-4a6f-96d9-9f9ec8fa45e0.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+ UUID: 89A67051-898A-4E2A-A874-E0165F274E630 TCGA-A1-A0SG-01A-PR Redacted Jcs-0-3 Circinoma,m fiHtnatig micropopillery.nitraducAl 8507f3 Site: brast Nos C50.7. Final Pathologic Diagnosis: A. Right axillary sentinel lymph node #1, count = 35oo, dissection: Metastatic. adenocarcinoma in one of two lymph nodes (1/2).. B. Right axillary sentinel lymph node #2, count = 500, dissection: No tumor in two. Iymph nodes (0/2). C. Right breast, partial mastectomy:. 1. Invasive micropapillary carcinoma, 2.1 cm, associated with microcalcifications; see. comment. 2. Atypical lobular hyperplasia.. 3. Fibroadenoma. 4. Microcalcifications in benign ducts D. Sentinel lymph node #3, count - 350, dissection: No tumor in two lymph nodes (0/2). Note: Breast Tumor Synoptic Comment - Laterality: Right. - Invasive tumor type: Invasive micropapillary carcinoma. - Invasive tumor size: 2.1 cm maximum diameter. The tumor is present in slices 4, 5, 9, and 10; however the tumor has been banked from slices 6, 7, and 8. Therefore, the tumor extends through seven consecutive slices, each with a width of approximately 0.3 cm, for a total maximum diameter of 2.1 cm. - Invasive tumor grade (modified Bloom-Richardson): 2 Nuclear grade: 3, 3 points. Mitotic count: < 10 mitotic figures/10 HPF, 1 point.. Tubule/papilla formation: Definite tubule formation in <10%, 3 points.. Page 1 of'4
+
+--- Page 2 ---
+Surgical Pathology - Working Draft Total points and SBR grade - 7 points, grade 2 - Lymphatic-vascular invasion: None identified. - Perineural invasion: None identified. - Resection margins for invasive tumor: - Deep margin: Negative (1 cm). - Medial margin: Negative (0.9 cm).. - Lateral margin: Negative (0.6 cm).. - Anterior/superior margin: Negative (0.5 cm). - Anterior/inferior margin: Negative (greater than 1 cm). - Ductal carcinoma in situ (DCis) type: None identified. - Microcalcifications: Present involving both benign ducts and invasive carcinoma.. - Lobular carcinoma in situ (LCiS): None identified. - Lymph node status: - Number of positive lymph nodes: 1. - Total number sampled: 6. - Diameter of largest metastasis: 2.1 mm. - Extranodal extension: Absent. - AJCC/UICC stage: pT2N1aMX. - Nontumorous breast tissue: Atypical lobular hyperplasia, fibroadenoma, and sclerosing adenosis. - Additional comments: We reviewed the original frozen section slides and concur with the frozen section diagnosis rendered. The metastatic tumor in Part A was only present in the additionally submitted sections of the lymph node (slide A2). Level sections on A2-A4 confirms the diagnosis. Select slides from part C were shown at the the faculty in attendance concurred with the above diagnosis of micropapillary type ot invasive carcinoma. Dr.. has reviewed A2 and concurs with the diagnosis. An immunohistochemical test for estrogen and progesterone receptors was performed on block C9. The test for estrogen receptors is positive. There is 3+ nuclear staining in >95% of tumor cells. The test for progesterone receptors is positive. There is 3+ nuclear staining in >95% of tumor cells. Result of HER2/neu test: This carcinoma is negative for HER2/neu oncoprotein over-expression. An immunohistochemical assay was performed on block C9 using the CB11 monoclonal antibody to HER2/neu oncoprotein. The staining intensity of this carcinoma was 1 on a scale of 0-3.. Carcinomas with staining intensity scores of O or I are considered negative for over-expression of HER2/neu oncoprotein. Those with a staining intensity score of 2 are considered indeterminate. We and others have observed that many carcinomas with staining intensity scores of 2 do not show gene amplification. All carcinomas with staining intensity scores of 2 are therefore submitted for FISH testing. The results of the FISH test are issued directly from the molecular cytogenetics laboratory. Carcinomas with staining intensity scores of 3 are considered positive for over-expression of HER2/neu oncoprotein. Tumors in this category show an excellent correlation betwcen the results of immunohistochemical and FiSH testing, and almost always show gene amplification. Slide A2 was shown at the departmental Consensus Conference, and the faculty in attendance concurred with the above diagnosis.. Intraoperative Consult Diagnosis FS1 (A) Right axillary SLN #1, biopsy: Negative for carcinoma. (Dr.. Clinical History The patient is a year-old woman with right breast carcinoma. Paee 2 of 4
+
+--- Page 3 ---
+Surgical Pathology  Working Draft Gross Description The specimen is received in four parts, each labeled with the patient's name and medical record number.. Part A is received fresh and labeled It consists of one pink-yellow, soft, fatty tissue that measures 3.1 x 2.5 x 0.8 cm. The specimen is strained and two candidate Iymph. nodes are found, the smallest is inked blue and submitted with a representative section of the largest. submitted for frozen diagnosis #1, thereafter submitted in cassette A1. The remnant of the largest lymph. node is transected and entirely submitted in cassettes A2-A3, and the remnant of the yellow fatty tissue is. submitted in cassette A4. Part B, additionally labeled consists of a single fragment of yellow, fibrofatty tissue measuring 2 x 1.8 x 0.4 cm. The specimen is entirely submitted in cassette B1.. Part C, additionally labeled  consists of a right breast specimen oriented with a short superior and a long stitch lateral. The specimen measures 3.2 cm from anterior to posterior,. 5 cm from medial to lateral and 6.5 cm from superior to inferior. The resection margins are inked as follows for microscopic evaluation: anterior superior in blue, anterior inferior in green and posterior in black. The specimen is serially sectioned from medial to lateral into twelve slices. There is gray-white, fibrous tissue in the superior half of the specimen in slices 3-11, measuring 2.4 x 2 x 1.5 cm. White fibrous tissue extends from this area to the anterior inferior aspect in slices 5-8. The gray-white fibrous tissue appears extend to the inked margin in the posterior superior aspect of slices 3 and 4, and appears to be O.5 cm from the anterior superior inked margins in slices 5 and 9. Representative sections are submitted as follows: Cassette C1: Representative medial margin, slice 1, bread-loafed.. Cassette C2: Representative section of slice 3. Cassettes C3-C5: Slice 4. Cassette C6: Representative section of slice 5. Cassette C7: Representative section of slice 6. Cassette C8: Representative section of slice 8. Cassette C9: Representative section of slice 9. Cassettes C10-C11: Representative sections of slice 10 Cassette C12: Representative section of slice 11. Cassette C13: Representative lateral margin, slice 12, bread-loafed.. Part D, additionally labeled consists of a single, yellow, fibrofatty tissue fragment. measuring 2.5 x 1.5 x 0.4 cm. The specimen is entirely submitted in cassette D1. The immunoperoxidase stain(s) reported above were developed and their performance characteristics determined by the They have not been cleared or approved by the U. S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded. as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (*CLlA") as qualified to perform high-complexity clinical testing.. Signed Fee Codes: Other Specimens - pecimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Right axillary contents Final Diagnosis Axilla, right, "contents," excision: 1. Scar tissue, fat necrosis and suture with giant cell reaction. No malignancy is. identified. Page 3 of 4
+
+--- Page 4 ---
+Surgical Pathology - : Working Draft 2. No metastatic tumor identified in five lymph nodes. (0/5). Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Final Diagnosis Review of irom : Breast, right, 10 o'clock, core biopsies: Infiltrating ductal carcinoma, SBR Grade 2; see comment. FND OF RFPORT Paxe 4 0f4
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diff --git a/output/text/026be35a-4528-4a87-9d09-29a50116d942.txt b/output/text/026be35a-4528-4a87-9d09-29a50116d942.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1ae52e77ace42cf5ae0438379274c46bbd80e857
--- /dev/null
+++ b/output/text/026be35a-4528-4a87-9d09-29a50116d942.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Patlent Name: Accession #: Med, Roc. #: Date of Procedure: DOB: Date of Receipt: Gender: Date of Report: Ref. Physkcian: Account #: Pallent Address: Blling Type: Additional Copy to: Rel. Source: Other Related Data: Biiling Type: Financial Number: Clinical Diagnosis & History: Left renal mass. Specimens.Submitted: 1: SP: Left kidnay and adrena DIAGNOSIS: 1} KIDNEY AND ADRENAL, GLAND, LEFT NEPHRECTOMY AND ADRENALECTOMY : - RENAL CEIL. CARCINOMA, PAPILLARY TYPE, WITH FOCAL SPINDLE CEIL (SARCOMATOID) GROKTI AND EXTENSIVE NECROSIS. THE TOMOR GREATEST DIAMETER IS 1O.O CM. THE TUMOR EXTENDS THROUGH THE RENAL CAPSULS BUT IS CONFINED WITHIN GEROTA'S FASCIA. NO INVASION OF THE RENAL VEIN IS IDENTIFISD. ALL SURGICA MARGINS ARE FREE OE TUMOR. THE NON-NEOPLASTIC KIONEY IS UNREMARKABIE. THE ADRENAL GLAND IS UNREMARKABLE. I ATTEST THAT THE ABOVE DIAGNO$K$ IS BA$ED UPON MY PERSONAL EXAMINATION OF THE SLIDES (ANDIOR OTHER MATERIAL), AND THAT I HAVE. REVIEWED AND APPROVEO THIS REPORT. Gross Descrintion: .} The specimen is received fxesh labelled "Jeft kidney and. adrenal". It consists of a kidney with attached adrenal gland, alnost entirely covered by adipose tissue, which totally weighs 720 grams. The kidney measures 14 cm in superior-inferior, 10 am antexior - posterior, and 9.5 cm medial to lateral. The adrenal gland measures 4.5 x 2 x 0.7 cn, and on cut. section is unremarkable. The surgical maxgins of the vein and of the ureter are shaved off. The kidney is bisected to reveal an almost entirely nacrotic mass, which is located in the cortical portion of the specinen.  The mass measures 10 x 6 x 5 cm, and is centrally, diffusely occupied by brown necrotie tissue. In the Page 1 0f 2
+
+--- Page 2 ---
+Deriohera. pottro., tie Kass wosis's of soft, yetlow to ion. rod The mass aggears tncepsula.cd ard well damarnsted excep in she moet ouoorior portion wher. it appears to intiltrate the Sorrina adipoee tieote. The xternsl surfao tosete w +aae ao ir is anlenr if rassd. kidr.ey parehm.yu. Luror. The aninvolved kioney apcoors mnrannrkable. kotrmmtatiyt snnticns are subnittod. Homary ef Rert.onr: 1....! JK arremarhrrie kidney Hiaso statn Kosults/tsuonts: NinroranreHane Reru.I Comurer." .:::: ::.: :.. A: .id : : 1:7 1 r .! : M +* : Page 2 of 2 END OF REPORT
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diff --git a/output/text/0284657b-545e-41e6-931d-fec0263260a4.txt b/output/text/0284657b-545e-41e6-931d-fec0263260a4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..306b8f1389f72df6d31d73a4f8b795df64e2377c
--- /dev/null
+++ b/output/text/0284657b-545e-41e6-931d-fec0263260a4.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Accession #: Date of Procedure: Date of Receipt: Date of Report: Account #: Billing Type: Additlonal Copy to: TCGA-BP-4977 Clinical Diagnosis & History: ith left upper pole renal mass.. Specimens Submitted:. 1: KIDNEY, LEFT UPPER POLE, PARTIAL NEPHRECTOMY 2: "DEEP MARGIN COLLECTING SYSTEM ON SINUS FAT." BIOPSY DIAGNOSIS: 1. Kidney, Left upper pole, partial nephrectomy Tumor Type: Renal cell carcinoma - Conventional (clear cell) type Fuhrman Nuclear Grade: Nuclear grade III/IV Tumor Size: Greatest diameter is 4.5 cm. Local Invasion (for renal cortical types):. Not Identified Renat Vein Invasion: Not present for evaluation.. Surgical Margins: Free of tumor Non-Neoplastic Kidney: Multlple papillary adenomas are present.. Adrenal Gland:. Not Identified Lymph Nodes: Not identified Staging for renal cell carcinoma/oncocytoma:. pT1 Tumor <=: 7.0 cm in greatest dimension limited to the kidney. 2. "DEEP MARGIN COLLECTING SYSTEM ON SINUS FAT," BIOPSY - Benign urothelial mucosa with chronic inflammation.. - Benign renal parenchyma.. Page t of 2
+
+--- Page 2 ---
+Note: has reviewed select slides in Part 1 of this case and concurs with the diagnoses.. TATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED ANO APPROVED THIS REPORT. Gross Description: 1.)The specimen is received fresh and is labeled "Left upper pole parlial nephrectomy peritumoral fat". It consists of 3 11.5 x 7.2 x 5.6 cm wedge shaped porlion of kidney with overlying perinephric fat. The kidney measures 6.5 x 5.5 x 4.6 cm. There is a suture marking the deep margin. The margin is inked black and the specimen is serially sectioned to reveal a well-circumscribed yellow tumor with ereos of hemorrhage and focal areas of cystification, measuring 4.5 cm in greatest dimension. The tumor is confined by  the renal capsule. The clearance trom the resection margin is 0.2 cm. The remainder of the specimen consists of renal parenchyma with a white well defined 0.4 cm subcapsular lesion, located 0.9 cm away from the main tumor.  Representatively submitted. Portions of the tumor are submitled for TPS.. Summary of sections:. T - tumor M - margin  RS - representative sections 2.) The specimen is received in formalin, labeled "deep margin collecting system on sinus fat", and consists of one irregularly shaped fragment of white-tan soft tissue with attached yellow lobulated adipose tissue, measuring 1.7 x 1.2 x 0.2 cm. Entirely submitted. Summary of sections:. U -- undesignated. Summary of Sections: Part 1:  KIDNEY, LEFt UPPER POLE, PARTIAL NEPHRECTOMY Block Sect. Site PCs 1 m 1 rs 1 4 t 4 Part 2:"DEEP MARGiN COLLECTING SYSTEM ON SINUS FAT," BIOPSY Block Sect. Site pCs 1 u 1 Page 2 of 2 END OF REPORT
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diff --git a/output/text/028b6a76-166f-48d7-a47c-11e50f53ab71.txt b/output/text/028b6a76-166f-48d7-a47c-11e50f53ab71.txt
new file mode 100644
index 0000000000000000000000000000000000000000..96cedc30d910507396e2aeacecda58499dc9e67c
--- /dev/null
+++ b/output/text/028b6a76-166f-48d7-a47c-11e50f53ab71.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+page 1 / 1 Department of Cancer Pathology. copy No. Date: Examination: Histopathological examination. Internal invoice No. Value of diagnostic procedure Examination No.: Patient: XXX PESeL: XXX Age: Gender: F 1cs-0-3 Material: 1. Multiple organ resection -- left breast with axillary tissues Unit in charge: Csvcinoma b fisnuHmg dvct,N0s 85o0f'3 Physician in charge: Sits! bUast, Nos C50.9 ih 4f1sf1 Material collected on: Material received on: ' Expected time of examination: up to 8 working days Clinical diagnosis: Cancer of the left breast. . Examination performed on: Macroscopic description:. Left breast sizdd 16.8 x 15.3 x 5.2 cm removed along with axillary tissues sized 10 x 6 x 5 cm and a 16.2 x 9.8 cm skin flap and a. fragment of the muscle sized 4 x 3 cm. Weight 620 g.. Tumour sized 3.5 x 3 x 3 cm found in the inner upper quadrant, 1 cm from the inner boundary, 0.2 cm from the base and 0.8 cm from the skin.. Microscopic description: Carcinoma ductale invasivum - NHG3 (3+3+3/36 mitoses/10 HPF - visual area: 0.55mm' Mamilla sine laesionibus. UUID:3DB4F9E-C918-4913-93E8-F18FF22CBA7C TCGA-D8-A1XK-01A-PR Redacted Glandular tissue with lesions of the type mastopathia fibrosa and cystica. Invasive lesions 0.1 cm away from the base. Axillary lymph nodes: Metastases carcinomatosae in Iymphonodis (No t/xv). Histopathological diagnosis: Carcinoma invasivum mammae sinistrae. invasive ductal carcinoma of the left breast  Metastases carcinomatosae in lymphonodis axillae (NHG3, pT2, pN1a). Cancer metastases in axillary lymph nodes.. Compliance validated b: Examination performed on: Results of immunohistochemical examination: No estrogen receptors found in neoplastic cell nuclei. No progesterone receptors found in neoplastic cell nuclei.. HER2 protein stained with HercepTestTM by DAKO. Negative reaction in invasive carcinoma cells ( Score = 0 ). Compliance validated by:1 CONTACT YOUR DOCTOR WITH THIS.M
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diff --git a/output/text/02946937-7635-4018-a8be-6447ed88fc53.txt b/output/text/02946937-7635-4018-a8be-6447ed88fc53.txt
new file mode 100644
index 0000000000000000000000000000000000000000..15622bbe4b0bb590d3b4fca310aee3c27bc2cce2
--- /dev/null
+++ b/output/text/02946937-7635-4018-a8be-6447ed88fc53.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+A description for each data field can be found in the 'Data description' worksheet (yellow tab). Sample Collection Details  Histology ar Sample Number  Sample Sample Site of Site of Year of Age at  Sample Days to Type  PreparatioTissue  Primary Sample  Sample Comments Procedure n (Event) Collection Collection Date (yrs) TUMOUR FF RENL BUFFY FF RENL
+
+--- Page 2 ---
+nd staging Days to Type of Site of Tumour  Histology Grade/  Pathologic Diagnosis Procedure  Primary Size (cm) Differentiat al T. (Histology) ion RESECT Right kidney Papillary renal ca., eosinophilic type x T2,NOS 14.5 RESECT  Right kidney 14.5 Papillary renal ca., eosinophilic type x T2,NOS
+
+--- Page 3 ---
+Pathologic Clinical M  Histology Comments Slide URL aI N NX  MO Furhman grade IlI. Extensive chronic pyelonephritis. NX MO Furhman grade lII. Extensive chronic pyelonephritis.
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diff --git a/output/text/02968a64-a0b5-410e-b56d-f065c60e68fe.txt b/output/text/02968a64-a0b5-410e-b56d-f065c60e68fe.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c0f046abcb2230e627c4914e32b3d83355c6c8a6
--- /dev/null
+++ b/output/text/02968a64-a0b5-410e-b56d-f065c60e68fe.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+AlU t1o13 Collection Date: FINAL DIAGNOSIS: Renal mass, Left, partial Nephrectomy -- A.  renal CeLl CarcinOmA, with fEatures Of both papiLLAry (PapilLARy Type 2) AnD Clear CELl Pu TS8. clea cll festuies (CONVENTIONAL) TYPES (ses comment). CARCINOMA MEASURES 1.7 cm IN GREATEST DImENSION. : 5% B. CARCINOMA IS CONFINED TO THe KIDNEy. c FUHRMAN NUCLEAR GRADE IS 3 OF 4. D. E. ALL SURGICAL MARGINS OF RESECTION ARE NEGATIVE FOR CARCINOMA. F.  NO LyMPHOVASCULAR INVASION IS SEEN G LimIteD bacKgrOund RENal Parenchyma with mODerate mIxed And fOCaLLy XANTHOGRANULOMATOUS INFLAMMATION, INCLUDING HEMOSIDERIN-LADEN MACROPHAGES. H. PATHOLOGIC TNM STAGE (AJCC 7th EDITION): pT1a NX MX. COMMENT: Histologic sectlons show a malignant neoplasm composed of architecturally-crowded papillae of eosinophillc ceils with. abundant stromal macrophages. Moreover, focl of cytologically malignant cells with distinct clear cell features are also. identlfied in the periphery of thls lesion. Results of paraffin section immunohistochemical analysis aiso highlight both cell populations (see microscoplc description), thereby supporting the above rendered diagnosis. CASE SYNOPSIS: SyNOPTIC DATA - PRImARy KiDNEy TUmOrS UUID:F0882D8F-D5D3-4DCC-9E7B-EE6D6557128D Redacted TCGA-B1-A656-01A-PR SpeCImen TypE: Partial nephrectomy LATERALITY: Left TUMOR SITE: Not specified FOCALITY: Unifocal TUMOR SIZE: Greatest dimension: 1.7 cm Additional dimensions: 1.5 x 1.5 cm. macroscopic extent Of tumor: Tumor limited to kidney HIstologic type: Papillary renal cell carcinoma. HISTOLOGIC GRADE (Fuhrman Nuclear Grade): G3 PATHOLOGIC STAGING (pTNM): pT1a pNX Number of regional lymph nodes examined: 0 pMX MARGINS:  Margins uninvotved by invasive carcinoma ADRENAL GLAND: Not present LYMPH-VASCULAR INVASION (LVI): Absent/not identified KiDnEy-REsidual TUmor (r):  RO
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diff --git a/output/text/029995e3-9d85-448b-a95b-db01ea6b12eb.txt b/output/text/029995e3-9d85-448b-a95b-db01ea6b12eb.txt
new file mode 100644
index 0000000000000000000000000000000000000000..bd9c7635f269bb9477ffdee5afebfa4ddbac2b46
--- /dev/null
+++ b/output/text/029995e3-9d85-448b-a95b-db01ea6b12eb.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID: F9C1971C-5BE2-4722-9A6C-CF4A4AD04352 TCGA-OR-A537-01A-PR Redacted Patient Name: Sex: Female Macroscopy Two vessels containing a material immersed in tormaldehyde solution, described as following: 1. product of en-bloc resection of the right kidney and an adrenal mass, weighting 503 g and measuring. 18 x 12 x 7 cm, previously sectioned. The tumor mass measures 12 x 7.5 x 7 cm (and weights 503 g) The cut surface is characterized by a partially encapsulated mass, intiltrating the surrounding fatty tissue, very close to the surgical margins. The tumor mass is multilobulated, brownish-yellow colored. with necrotic areas. The normal adrenal tissue is not clearly distinguishable. The right kidney is. attached to the mass, but no signs of invasion are seen. The surgical margins were stained with green indian ink. 2. Hepatic margin, consisting of two brownish fragments, measuring 2 x 1 x 0.4 cm. Conclusion: Product of right nephrectomy and right adrenal mass resection: Adrenocortical carcinoma with the following features: IcDO-3 Largest diameter -- 12 cm. Carcinorro, adnnol Nuclear grade (Fuhrman) -- 4 83703 Corticis Diffuse architectural pattern - present Site? BAtrenas g land. :Clear cells in < 25% of the neoplasm -- present cortee 0 474.Z .Areas on necrosis - present AtO y/80f1 3 .Mitotic count -- 3 in 50 H.P.F. Atypical mitosis - present  Capsular invasion - present  Venous invasion -- present
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diff --git a/output/text/02a1fe95-1169-4ce1-803d-1d2222b454c2.txt b/output/text/02a1fe95-1169-4ce1-803d-1d2222b454c2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..61b87944cdb9651c9badb59512a05928a6b7a46d
--- /dev/null
+++ b/output/text/02a1fe95-1169-4ce1-803d-1d2222b454c2.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SPECIMENS: CARD CASE COMMENT: FIRST PATHOLOGY DATE FIRST PATHOLOGY REPORT: PRIMARY PATHOLOGIST: 2 DIAGNOSIS-1 M9593 MALIGNANT LYMPHOMA, NOS SPECIMEN-1 T07 SPLEEN
+
+--- Page 2 ---
+CHAI AD ONRNAVAA  RANGH ) to PARHICLAATE XYES ONO TSIARAFFIN ....4h1o. HARRIATE AMPLE. LWES 43. MFLASTIC AVERAGE: UNEVALUAELE O CRURERIIG CRIL COUNT DNOT APPLICAnLE  MYELOMLAST8 A PnOMYELOCYTE3 D) MEGAKAAYODLASTS CTMONOULASTS : PROMONIXYTES (JIYMPHHODLASTS + LYNPHOCYTES CLONES:YES Ono _  not eyaluable AS A  OF ALL NUCLEATEO CELLS (ANC) 0 t0 C] 1030 -5 55 EOSINOPHILIA: Onone QSPAnSE ) MAAKEO PER HPF (AM x tiNr) 010  1030 30-100 > 100 OASOPHILIA: ONONE SPARSE OMARKEO NOnMAL OA DTAPLAOTICHRMOPOIEGIS NOt EVALUAOL (Cylo/ngy unAyallntle) M:e natio: .... CEUURARITY low NORMAL HIQH Dyspl.  PLASMA CELLS INCAEASED QOECHEASED QRANULOCYIES. Q0 D1 04 Oy EOSINOPHILS INCREASEO QOECAEASED ERYTHROIDS. 00 D2. Oy dR BASOPHILS CINCREASED DDECnEASED MONOCYTES: 01 05 Oy DN HISTIOCYTES OINCREASED QOECREASED LYMPHIOCYTES: 00 00 04 5 IRON (IF EYALUABLE INCREASEO ODECAEASED MEGAKAAYOCKTES/HPF: 2.2 OTHER. OINCREASEO QDECREASED RANGE: MEAN FMYRLOFIOnOGIS. NOT EVALUABLE (spociAl staIns unavallablo) TINALTRATESOTHER THANNOTEOAROYEUNDSRLEUKEMICA CELLCOUNT: HAEPAS/GIEMSA DRetIcULin STAin  COLLAGEN STAIN ANONE sheets ONODULES ONUMOER: / Hpf: total no. QRADE OPARATRABECULAR Ointenstitial O 1  NO INCREASE IN RC TICULIN OLYMPHOID PIASMACYTIC CARCINOMA O? * FOCAL INCREASE IN RETICULIN AEACTIVE ONEOPLASTIC BOADERLINE O3 + DIFFUSE INCREA$E iN RETICULIN PROPORTION OF SEGTION INFILTRATED:E Dother . O 4  DIFFUSE INCREASe IN RETICULIN AND COLLAGEN S  COLIAGEN CONSPICUOUS,ARCHITECTURE DISTORTION 3 RIGHT ILtAC CREST % AVERAGE:  S6 : GRAOE 5a PLUS NEW DONE FORMATION (OSTEOSCLEROSIS) LEFT ILIAC CAEST % ASPIRATE: KMARROWIAPRINTASHIEARDIFICOUNT % % ONOTAYAILADLE N 'MOnoalAsts,+fy: NEUTRO, Eos. BASO 0,6. rr MYEL OSLASTS MONOCYTES . CELLSCOUNTED 1.0 PROMYELOCYTES NUC. ERYTHROID 21.2 mk.inc. 5.0 0.2 PLATELETS MYELOCYTES LYMPHORLASTS: H+ree. MEGAKARYOCYTES .inc. 9.4 0.4 METAMYELOCYTES LMPHOCYTES5 R MEGAKARYOBLASTS 28.6 0.6 STASS PLASMA CELL'S 0.6 21.6 AUEA nOOS SEGMEnTED Histiocytes 02 ETHERAPY :.:  HCEOR 12.5 SIDEAOBLASTS H08 - ONO DCp ORT TRANSP. 8.65 OTHEn. WBO x 10L  x 10/L Last date: CYTOCHEMICAL CELLS: % PX $8 CAE ANBE ANAE AP TAAP PAS OtheR SCORE( TOTAL: Onot: AVAILADLE DlAdnosiax(eroysns Bdeirabbreylated keys) ORDERLY GRANULOPOIESIS AND BRXTHROPOIESIS.  MODERATE MEGAKARYOCYTIC HYPERPLASIA. NEGATIVE FOR LYMTHOMA. CELLULARITY SSZ. LYMPHOCYTES S.4X. RIGHT AND LEFT ILIAC CRKET BtOFSt$T,SECTIONS, IMPRIHTS AND SMEARS IMMUNO PHENOTYPE: SIgnED. FEA SIGNED. PATHOLOGY FILe
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diff --git a/output/text/02c1c48a-f029-4d20-8ab3-d366da0f1c29.txt b/output/text/02c1c48a-f029-4d20-8ab3-d366da0f1c29.txt
new file mode 100644
index 0000000000000000000000000000000000000000..81737be02bdcd7ffe543cd1f7f4ca8ca37b42194
--- /dev/null
+++ b/output/text/02c1c48a-f029-4d20-8ab3-d366da0f1c29.txt
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+
+--- Page 1 ---
+SURGICAL PATHOLOGY Case Number : Redacted Diagnosis: A: Pancreas, bile duct margin, biopsy - No tumor seen. B: Pancreas pancreatic duct margin, biopsy - No tumor seen C: Superior pancreatic lymph node, biopsy - One lymph node with no malignancy identified (0/1) D: Aortocaval lymph node, biopsy - One lymph node with no malignancy identified (0/1) E: Pancreas, duodenum, pancreaticoduodenectomy. Tumor Histologic Type: adenocarcinoma. Histologic grade: moderately differentiated Tumor size: 3.5 cm Icd-o-3 Extent of invasion: adenocarcinomg, Nos Peripancreatic soft tissues: present Duodenum: identified. 8l40|3 Ampulla: identified Sik: Pancregs, huad Lymphatic Invasion: not identified. cQ5,o Venous Invasion: not identified 81a3|ia ep Perineural Invasion: present Margins:. Pancreatic neck: negative. Bile duct: negative Posterior pancreatic surface (deep radial margin): negative (<1 mm) Peripancreatic soft tissues: negative (<l mm). Proximal (gastric): negative Distal (duodenal): negative Regional lymph nodes:. Total number with metastasis: 0
+
+--- Page 2 ---
+Total number examined: 8 (including specimens A and B) AJCC PATHOLOGIC TNM STAGE: pT3 pNO pMx Note: This pathologic stage assessment is based on information available at the time of this report, and is subject to change pending'clinical review and additional information.. Intraoperative Consult Diagnosis: An intraoperative consultation is requested by FSAl: Pancreas, bile duct margin, biopsy - No tumor seen FsBl: Pancreas, pancreatic duct margin, biopsy. - No tumor seen'. Frozen Section Pathologist:, Clinical History: The patient is a :year-old with pancreatic head cancer. Gross Description: Specimen A is received fresh in the frozen section room appropriated labeled "bile duct margin for frozen section" and consists of a 2.2 x 0.6 x 0.6 cm red/tan soft tissue fragment with no lumen. The specimen is entirely submitted for frozen section and resubmitted in block FsAl,. Specimen B is received fresh in the frozen section room appropriately labeled "pancreatic duct margin for frozen section" and consists of a 1.0 x 0.8 x 0.3 cm red/tan soft tissue fragment. The specimen is entirely submitted for frozen section and resubmitted in block Fsbl, Specimen c is labeled as "superior pancreatic lymph node, biopsy". Received is a single pink/tan soft tissue fragment with focal erythematous areas and cautery, 1.2 x 0.8 x 0.5 cm. The specimen is serially sectioned and the entire specimen is submitted in block C1, Specimen D is labeled as "aortocaval lymph node, biopsy" and consists of a white to pink/tan soft tissue fragment 2.2 x 0.9 x 0.7 cm, with focal erythematous areas and cautery. The specimen
+
+--- Page 3 ---
+is serially sectioned and submitted in block D1,. Specimen E is labeled "Whipple specimen." Specimen fixation: formalin Specimen type: Whipple. Organs received (Whipple Specimen): stomach (3.5 cm long x up to. 6.5 cm in circumference), head of pancreas (4 x 3 x 1.5 cm),. duodenum (15 cm long x up to 6.7 cm in circumference), common. bile duct (3.6 cm long x 1.7 cm in circumference proximally) Orientation: common bile duct-yellow, pancreatic body. margin-blue, uncinate-black, peripancreatic soft tissue-green Tumor location: head. Tumor dimensions: 3.5 x 3.0 x 2.5 cm Gross appearance of tumor: solid, firm, variegated, tan/white; There is minimal amount of normal pancreas present.. Extent of invasion:. Confined / non-confined to the pancreas: confined Involvement of the ampulla: absent Involvement of the duodenum: absent Involvement of the bile duct: possibly into wall Involvement of adjacent vessels: n/a. Spleen (if applicable): n/a Gallbladder (if applicable): n/a. Stomach (if applicable): uninvolved Surgical margins:. Pancreatic body: negative (0.2 cm) Uncinate (Retroperitoneal): negative (<0.1 cm).
+
+--- Page 4 ---
+Common Bile duct: negative (0.2 cm) Proximal margin (stomach): negative (3.5 cm) Distal margin (duodenum): negative (9.3 cm) Peripancreatic soft tissues: positive Lymph nodes: multiple lymph node candidates are identified ranging in size from 0.5 up to 2.0 cm Other remarkable findings: none Digital photograph taken: no Tissue submitted for special investigation: no Block summary: El, E2 - proximal (stomach) margin, en face E3 - distal (duodenum) margin, en face E4 - pancreatic body margin, en face E5 - uncinate margin with closest approach of tumor, perpendicular E6 - closest approach to common bile duct margin, perpendicular, full thickness, bisected. E7 - remaining common bile duct margin, en face E8-e9 - mass with relationship to common bile duct and duodenum, one section, bisected. E10 - tumor with pancreatic duct El1-E12 - tumor with relationship to ampulla E13 - two lymph node candidates, one inked black and both bisected E14-El5 - largest lymph node candidate, serially sectioned E16 - two lymph node candidates E17 - one lymph node candidate, bisected
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diff --git a/output/text/02cf0b0c-78e8-4c3d-b476-580dd616df98.txt b/output/text/02cf0b0c-78e8-4c3d-b476-580dd616df98.txt
new file mode 100644
index 0000000000000000000000000000000000000000..00744f130604561d618e2eaaf25f84f4540c2aad
--- /dev/null
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+
+--- Page 1 ---
+Department of Cancer Pathology. copy No. Date: Examination: Histopathological examination (cito) Internal invoice No. Cost of diagnostic procedure Examination No.: Patient: XXX pesel: XXx Age: Gender: F Material: Multiple organ resection - left breast and axillary tissues ICs-0-3 cavCiOmn hf1f^txy dut,n0s 85vtf3 Unit in charge: Physician in charge: ref. No. Material collected on: Material received on: Expected time of examination: 5 working days Clinical diagnosis: Examination performed on:. Macroscopic description: Left breast, sized 22 x 18 x 9 cm, removed with axillary tissues sized 10 x 11 x 5 cm and with a skin flap of 23 x 19 cm. Nipple retracted, skin resembling orange peel.. Tumour sized 6.0 x 6.0 x 3.5 found on the border of upper quadrants, located 3.0 cm from the upper boundary, 1.5 cm from the base and 0 cm from the skin. Lymph nodes 1.8 cm in length.. Microscopic description: Carcinoma ductale invasivum - NHG3 (3 + 2 + 3 / 35 mitoses/10 HPF - visual area 0.55 mm). Mamilla sine laesionibus. Glandular tissue showing lesions of the type mastopathia fibrosa et cystica. AXILLARY LYMPH NODES: Metastases carcinomatosae in lymphonodo (No I/xxi). Infiltratio capsulae lymphonodi et telae perinodalis. Histopathological diagnosis: Carcinoma ductale invasivum mammae sinistrae. invasive ductal carcinoma of the left breast.  Metastases carcinomatosae in lymphonodo (No I/xxi) (NHG3, pT3, pNla). Cancer metastases in the lymph nodes (No I/XxI) UUID:18198706-8844-452A-8F58-8880A239717C TCGA-D8-A1Y1-01A-PR Redacted
+
+--- Page 2 ---
+e 2 / 2 Results of immunohistochemical examination: Estrogen receptors found in 10-75% of neoplastic cell nuclei. Progesterone receptors found in over 75% of neoplastic cell nuclei. HER2 protein stained with Ventana's Pathway HER-2/neu (4B5) rabbit antibody. Negative reaction in invasive cancerous cells (Score=3+). C'ompl CONTACT YOUR DOCTOR WITH THIS REPORT!
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diff --git a/output/text/02d89b0d-8bd7-4219-af20-3ac901064f22.txt b/output/text/02d89b0d-8bd7-4219-af20-3ac901064f22.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b9c37212c483a59f2a9724f914103fcbfb4bb665
--- /dev/null
+++ b/output/text/02d89b0d-8bd7-4219-af20-3ac901064f22.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+ID03 'srceome, drsttelial NoS 8/2013 UUID:0B1A1E8B-78FD-43B8-A6B1-2E7EB251FD52 TCGA-4Z-AA87-01A-PR Redacted Sete: MadserNos C67.J Ht~ 3/18/14 Collect date: (MM/DD/YYYY) PATHOLOGY REPORT: PRIMARY SITE: Bladder 1 - "Left ureteral margin, paraffin from preoperative exam: Free of neoplastic involvement.. 2 - "Right ureteral margin, paraffin from preoperative exam: Free of neoplastic involvement. 3 - "Prostate + bladder'': High-grade urothelial carcinoma of the bladder characterized as follows: Measure of neoplasia in its major axis: 6.5 cm.. Ulceration present. Extensive areas of necrosis. Involvement of: bladder. all prostate right seminal vesicle and fibroadipous peri-visceral connective tissue. Neural infiltration present. Lymphatic vascular invasion doubtful.. Sanguineous vascular invasion not detected. Surgical margins free of neoplastic involvement.. 4 - "Left lymphadenectomy": Free of neoplastic involvement (0/3) 5 - "Right lymphadenectomy": Free of neoplastic involvement (0/2). bv 12f2of13 criterk
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diff --git a/output/text/0300a1b6-0a54-4fcc-a3fe-0e9e986cdf5d.txt b/output/text/0300a1b6-0a54-4fcc-a3fe-0e9e986cdf5d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5baaef2efcbccc18b424ace9c5a56abb75a0e323
--- /dev/null
+++ b/output/text/0300a1b6-0a54-4fcc-a3fe-0e9e986cdf5d.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Surgical Pathology Histopathological Examination Pre-Op Diagnosis : Right Renal Mass On Native Kidney.Right Hydronephrosis Of Transplanted Kidney Order Physician. Specimens : Kidney, Right. Frozen Diagnosis. Report : GROSS EXAMINATION: The specimen is received fresh in a container labeled with the name of the patient and labeled as kidney, right. The specimen consists of a kidney and attached perinephric fat. The kidney measures 6 x 3.8 x 2.2 cm and weighs 47 g. The ureter and vascular margins of resection are submitted in block 1. The renal sinus/hilar margin is submitted in block 2. Sectioning shows an oval tan mass in the mid lateral aspect which measures 3.1 cm in greatest dimension. The mass. bulges against the capsule but is not grossly adherent to the capsule. A section of capsule overlying the mass is submitted in block 3. The mass does not grossly involve the. renal sinus. Sections of the mass are submitted in blocks 4-7. The pelves and calyces are not grossly dilated. The cortex averages 0.l cm. A random section of kidney is submitted in block 8. Sectioning through the attached fat shows no lymph nodes or adrenal tissue. This case was reviewed with DIAGNOSIS BASED ON GROSS AND MICROSCOPIC EXAMINATION: Kidney, right, nephrectomy:  Papillary renal cell carcinoma, type I, Fuhrman grade 2, 3.1 cm, confined to kidney with negative margins (see cancer case summary checklist below). KIDnEy: Nephrectomy, Partial or Radical (Version 3.l.0.0) PROcEuRE: Radical nephrectomy SPECIMEN LATERALITY: Right THIS CONFIDENTIAL AND PRIVILEGED DOCUMENT/INFORMATION IS PROTECTED BY FEDERAL AND STATE LAW.  UNAUTHORIZED DISCLOSURE, DISSEMINATION OR DUPLICATION IS PROHIBITED Page 1 of 2
+
+--- Page 2 ---
+TUMOR SITE: Middle TUMOR SIZE: Greatest dimension: 3.1 cm TUMOR FOCALITY: Unifocal MACROSCOPIC EXTENT OF TUMOR: TumOr limited to kidney HIsToLogic TypE: Papillary renal cell carcinoma, type I SARCOMATOID FEATURES: Not identified HISTOLOGIC GRADE (FUHRMAN NUCLEAR GRADE): Grade 2: NuClei slightly irregular, approximately 15 microns, nucleoli evident. MICROSCOPIC TUMOR EXTENSION: Tumor limited to kidney. MARGINS:  Margins uninvolved by invasive carcinoma. LYMPH-VASCULAR INVASION: Not identified. PATHOLOGIC STAGING (pTNM): Primary Tumor (pT): pTla: Tumor 4 cm or less in greatest dimension, limited to kidney. Regional Lymph Nodes (pN): pNx: Cannot be assessed, no nodes submitted or found. Distant Metastasis (pM): Not applicable. PATHOLOGIC FINDINGS IN NONNEOPLASTIC KIDNEY:  End stage renal renal disease with numerous sclerotic glomeruli,. thyroidization of tubules, fibrosis, and chronic inflammation.. COMMENT: This case was delayed to perform a panel of immunostains which shows the tumor cells to be positive for ck7, EMA, pankeratin, vimentin, CDl0, Rcc, pAx8, and P504S. They are negative for wTl. Positive and negative controls stained appropriately. Based on the histologic appearance and immunoprofile, this neoplasm is best interpreted as papillary renal cell carcinoma, type I. A fragment of tumor is associated with the edge of the soft tissue on the section of the ureteral and vascular margins. Multiple step sections are examined. Based on the very peripheral location of the tumor with no macroscopic evidence of involvement of the medulla or renal sinus, this tumor focus is best interpreted as a knife carry-over or a floater. Intradepartmental consultation obtained. Results communicated to
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diff --git a/output/text/03035735-a615-4275-812f-c60b51af8173.txt b/output/text/03035735-a615-4275-812f-c60b51af8173.txt
new file mode 100644
index 0000000000000000000000000000000000000000..48db6c4ddb90a79123cb00c533e3f9bba6cb6829
--- /dev/null
+++ b/output/text/03035735-a615-4275-812f-c60b51af8173.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+ UUID:BF3E21AE-D9DC-4011-908A-32C6C1FE10FB 1C D-O-3 TCGA-BC-A8YO-01A-PR Redacted Caru +nn', die ratee. Welar NDS S1703 SURGICAL PATHOLOGY Siti dlur Cx5.0 Case Number : yJ y13|4 Diagnosis: A: Gallbladder, cholecystectomy. - Benign gallbladder with no significant pathologic abnormality - No carcinoma identified B: Liver and adherent ascending colon and retroperitoneal soft tissue, segments 5 and 6, partial hepatectomy and en block resection Histologic tumor type/subtype: hepatocellular carcinoma. Histologic grade: Grade 3 (Edmondson and Steiner). Number of tumors: 1 primary lesion with multiple subcentimeter satellite lesions Tumor size: 1l cm Tumor location: Segments 5 and 6. Tumor necrosis: present (involves approximately 20% of microscopically examined tumor). Worst tumor differentiation: grade 3 (Edmondson and Steiner) Vascular invasion: present, macrovascular. Perineural invasion: not identified. Capsular invasion: Present Margins: uninvolved by carcinoma; tumor is 8 mm from the closest. inked retroperitoneal soft tissue margin and 1.7 cm from the hepatic resection margin (colonic and vascular en face margins negative for tumor) Lymph nodes: 1l benign lymph nodes present within pericolonic adipose tissue (0/11) Satellite lesions: present (multiple subcentimeter lesions). Background liver: chronic hepatitis, etiology unknown, grade 1,. stage 2 (see comment).
+
+--- Page 2 ---
+Other extrahepatic spread: present, tumor focally extends through the capsule/visceral peritoneum to involve fibrous adhesions (no microscopic evidence of tumor involvement within underlying colon and soft tissue) Additional findings: - Eleven benign colonic lymph nodes (0/11) AJCc Pathologic TNM stage: pT4 pNx NoTE: This pathologic stage assessment is based on information. available at the time of this report, and is subject to change pending clinical review and additional information.. C: Bowel, ileum, resection - Benign small bowel with fibrous serosal adhesions, acute. serositis, and serosal hemorrhage with hemosiderin laden macrophages - No carcinoma identified Comment: Microscopic examination of non-neoplastic liver reveals fibrotic portal tracts with mild bile ductular proliferation and an. associated chronic lymphocytic infiltrate consisting almost entirely of lymphocytes. No prominent plasma cell infiltrate is identified.. No piecemeal necrosis is identified. There is mixed macrovesicular and microvesicular steatosis involving less than 5% of the hepatic parenchyma and no features are present to suggest involvement by. steatohepatitis. A trichrome stain highlights areas of periportal fibrosis with no evidence of bridging fibrosis or cirrhosis. A reticulin stain also highlights periportal fibrosis but shows an otherwise normal hepatic. plate thickness. A DpAs stain shows no evidence of alpha-1- antitrypsin deficiency (no DpAs positive globules identified within hepatocytes). An iron stain shows a mild increase in hepatic. iron (grade 1 of 4). The findings are consistent with chronic hepatitis, grade l, stage 2. The differential diagnosis includes viral hepatitis and autoimmune hepatitis. Correlation with clinical history and laboratory studies is recommended to determine the. etiology of the chronic hepatitis. Clinical History: The patient is a -year-old female with a clinical diagnosis of. HCC.
+
+--- Page 3 ---
+Gross Description: Specimen A is received with one appropriately labeled container additionally labeled "gallbladder".. Previously opened or disrupted: No. Measurements: 4.6 x 3.1 x 0.9 cm External surface: Yellow/green, smooth and glistening Luminal contents: Green viscous fluid Stones present: No Mucosa: Green and velvety Wall thickness: 1 mm Other comments: No Block #: Al - Cystic duct margin and representative section Tissue remains in formalin. Specimen B is received in formalin appropriately labeled "segments 5 and 6". Specimen Type: Segmentectomy and right hemicolectomy Specimen Weight: 745 grams Measurement: 12.5 x 11 x 7 cm segment of liver with attached right hemicolectomy consisting of 3 cm of terminal ileum and 14 cm of cecum and ascending colon. Orientation: Anatomical. The liver resection margin is inked blue. Capsule: There is a 14.5 cm yellow bulging defect with adherent mesenteric fat and colon. Where the tumor is adherent to the mesentery, the surface margin is inked green. The remainder of the capsule is tan/brown and smooth. Beneath the capsular defect there is an 11 x 9 x 6.5 cm white to tan nodular partially circumscribed mass with multiple adjacent budding nodules. Mass: Further sectioning reveals a blood vessel that is plugged with tumor thrombus. Additionally, the mass extends through the capsule to within 1.1 cm of the green inked mesenteric margin. Where the mass is adherent to the bowel, it appears to extend to but not grossly invade the capsule. The tumor is 1.7 cm from the blue inked hepatic resection margin, and widely free of the distal margin. Adjacent liver tissue: Tan/brown and unremarkable. The colonic mucosa is pink/tan with normal folding. The appendix is surgically absent.. Major portal vein/ hepatic vein: Gallbladder: See specimen A. Block Summary: B1 - Closest blue inked resection margin, perpendicular B2 - Proximal colonic margin, en face
+
+--- Page 4 ---
+B3 - Distal colonic margin, en face. B4 - Tumor in relationship to the capsule and adjacent uninvolved tissue B5 - Tumor within a blood vessel. B6 - Representative sections of multiple adjacent tumor nodules B7 - Additional tumor nodule. B8 - Uninvolved liver away. B9-Bl0 - Tumor in relationship to the green soft tissue margin, perpendicular Bll - Tumor in relationship to the bowel B12 - Tumor in relationship to lateral sidewall muscle B13 - Vascular margin with thrombus, en face B14-B15 - Multiple colonic lymph nodes Container c is additionally labeled "ileum." It holds a 6 cm in length x 2.1 cm in diameter segment of small bowel. There is a 2.5 x 1.8 cm area of hemorrhagic adhesions 0.5 cm from the closest mucosal margin. The serosal surface is pink/tan and smooth. Opening reveals pink/tan mucosa with normal folding. Beneath the hemorrhagic adhesions, the cut surface is yellow fat. Block summary: c1-c2 - unoriented mucosal margins, en face c3 - hemorrhagic adhesions, en face. 1243 113
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diff --git a/output/text/03174138-27f2-4425-a39c-dbaf95adc14a.txt b/output/text/03174138-27f2-4425-a39c-dbaf95adc14a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..840056b13cff6bb394ce0da61ba7ea0b9e06852a
--- /dev/null
+++ b/output/text/03174138-27f2-4425-a39c-dbaf95adc14a.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Sample Number Sample Type TUMOUR Diagnosis  Renal cell carcinoma, papillary type (types 1 and 2) Year of Sample Collection Age at Sample Collection (yrs)  Days to Procedure Date  Days to Diagnosis Type of Procedure Resect  Site of Tissue/Primary (Histology)  Left kidney Tumour Size (cm) 3  Histology  Renal cell carcinoma, papillary type (types 1 and 2)  Grade/Differentiation III  Pathological T T1a  Pathological N  NX  Clinical M  MO Histology Commentse Grade/Diff: Fuhrman grade 3/4. Sample Number Sample Type  BUFFY Year of Sample Collection. Age at Sample Collection (yrs)  Days to Procedure Date. Days to Diagnosis UUID:E24C3E1C-D148-4C68-A691-CD1AF8014C4B TCGA-HE-A5NH-01A-PR Redacted IcDo-3 8QbD/3 Site  Kidnuy NbS C64.9 OpO`xnJ3 W y7j3 riteria iagnosis ual/Symhr ase is cir
\ No newline at end of file
diff --git a/output/text/03241ad5-a4f3-4a59-98f8-8b9a54e9765d.txt b/output/text/03241ad5-a4f3-4a59-98f8-8b9a54e9765d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f61956b7265e74fef14194617e66081385292a4b
--- /dev/null
+++ b/output/text/03241ad5-a4f3-4a59-98f8-8b9a54e9765d.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+UUID: 030860D0-66DF -46FF -95A3-2AE4852D5C19 TCGA-S3-A6ZH-01A-PR Redacted MRN: Sex/DOB: Female Patient: Admission Date: Discharge Date: Ordering Physician: Surgical Pathology Report Collected Date/Time: Accession Number: Received Date/Time: Final Diagnosis A. LEFT HIGHEST AXILLARY NODE, EXCISION: - METASTATIC CARCINOMA IN ONE LYMPH NODE (1/1). B. LEFT BREAST AND AXILLARY CONTENTS, MASTECTOMY AND LYMPHADENECTOMY: -INVASIVEDUCTALCARCINOMA,GRADE3 - METASTATIC CARCINOMA IN THIRTEEN OF NINETEEN LYMPH NODES (13/19). - MARGINS ARE NOT INVOLVED. - SEE TEMPLATE. C. LEFT LEVEL I AXILLARY LYMPH NODE, EXCISION: - NO EVIDENCE OF CARCINOMA IN ONE LYMPH NODE (0/1). D. SKIN, LEFT AXILLA, EXCISION: -FOLLICLE INFUNDIBULAR CYST,RUPTURED AND INFLAMMED tc9-0-3 (Electronic signature) Verified: CtcFl 85co/3 Synoptic Report SPECIMEN TYPE: Excision LYMPH NODE SAMPLING: DBusst,ypper outi Axillary dissection SPECIMEN SIZE: Ruasrsnf- C 50.4 Greatest dimension: 24 cm *Additional dimensions: 18 x 5 8/Q/1 3 LATERALITY: Left TUMOR SITE: Printed by: Page l of 4 Print Date/Time: Copied tc Distribute to: Patient I rcations:
+
+--- Page 2 ---
+MRN: Patient: Sex/DOB:  Female Surgical Pathology Report Collected Date/Time: Accession Number: Received Date/Time: Upper outer quadrant SIZE OF INVASIVE COMPONENT: Greatest dimension: 7 cm (3 cm in this specimen and 4 cm in previous lumpectomy HISTOLOGIC TYPE: Invasive ductal carcinoma HISTOLOGIC GRADE: Tubule formation: Tubule formation: Minimal less than 10% (score = 3) Nuclear pleomorphism: Nuclear pleomorphism: Marked variation in size, nucleoli, chromatin clumping, etc. (score = 3) Mitotic count (for those using the Nottingham system) - for a 25x objective with a field area of 0.274mm2: Mitotic count (25x objective): 10 to 20 mitoses per 10 HPF (score = 2) Nottingham Grade III: 8-9 points PRIMARY TUMOR (pT): pT3: Tumor more than 5.0 cm in greatest dimension REGIONAL LYMPH NODES (pN): pN3a: Metastasis in 10 or more axillary lymph nodes (at least 1 tumor deposit greater than 2.0 mm), or metastasis to the infraclavicular lymph nodes Number examined: 21 Number involved: 14 DISTANT METASTASIS (M): pMX: Cannot be assessed MARGINS:  Margins uninvolved by invasive carcinoma Distance from closest margin: 15 mm Specify which margin: posterior/deep *VENOUS/LYMPHATIC (LARGE/SMALL VESSEL) INVASION (V/L): *Present *MICROCALCIFICATIONS: *Not identified *ADDITIONAL PATHOLOGIC FINDINGS: adenosis. Biomarkers evaluated in previous specimen (. ER: positive, 98% PR: positive, 8% Her-2neu: equivocal 2+ by IHC, not amplified by FISH. Source of Specimen A LEFT HIGHEST AXILLARY NODE B LEFT BREAST AND LEFT AXILLARY CONTENTS c LEVEL I LEFT AXILLARY LYMPH NODE D LT AXILLA Page 2 of 4 Print Date/Time:
+
+--- Page 3 ---
+MRN: Patient: Sex/DOB:  Female Surgical Pathology Report Collected Date/Time: Accession Number: Received Date/Time: Clinical Information female with left breast cancer on ultrasound core needle biopsy status post. PRE-OP DIAGNOSIS: Left breast cancer and axillary hydradenitis POST-OP DIAGNOSIS: Same TYPE OF PROCEDURE: Left mastectomy and left axillary hidradenitis node dissection Gross Description Specimen is received in 4 parts: A. The specimen is labeled "LEFT HIGHEST AXILLARY NODE" and is received unfixed. It consists of one nodule of fatty yellow-. tan tissue with staples measuring 1.2 x 0.7 x 0.5 cm. On sectioning, there is one lymph node identified measuring 0.7 cm in maximum dimensions. The lymph node is bisected and entirely submitted in cassette A1.. Time specimen was removed from the patient Time specimen was sectioned and placed in formalin: Ischemic time: 30 minutes B. The specimen is labeled "LEFT BREAST AND AXILLARY CONTENTS " and is received in formalin. (The specimen is in the formalin more than  It consist of mastectomy specimen with lymph nodes weighing 480 grams and  measuring 24 x 18 x 5 cm with brown skin ellipse measuring 17 x 4 cm, containing grossly unremarkable 1.5 cm in diameter nipple.. [The skin is tagged with a black stitch designating 12:00]. The posterior margin is composed of smooth fascia which is inked black. The anterior margin of resection is inked with blue ink. The breast is slices in sagittal planes revealing 3 x 3 x 2.5 cm an ill-defined white-tan mass which is 1.5 cm away from the deep fascial margin of resection. This mass is located in the upper outer quadrant (approximately 2:00 position). The remaining portions reveal unremarkable yellow mammary fat with streaks of white-gray mammary parenchyma. An axillary fat pad measuring 7 x 5 x 3 cm. On sectioning multiple lymph nodes are identified. Some lymph nodes are white in and firm in consistency. The largest lymph node measuring 2 cm in greatest diameter. Representative sections are submitted as follows: B1 = nipple B2-B5 -- mass B6 = mass closest deep fascial margin of resection B7 = upper inner quadrant B8 - lower inner quadrant B9 = lower outer quadrant B10 -- 6 lymph nodes B11 = bisection of a single lymph node B12 = bisection of a single lymph node B13 = representative sections of 3 lymph nodes B14 = bisection of a single lymph node B15 = representative section of the single lymph node B. 16 = bisection of a single lymph node B-17 =- two small lymph nodes B. 18 = bisection of a single lymph node Time specimen was removed from the patient: Page 3 of 4 Print Date/Time:
+
+--- Page 4 ---
+MRN: Patient: Sex/DOB: Female Surgical Pathology Report. Collected Date/Time: Accession Number: Received Date/Time: Time specimen was sectioned and placed in formalin:. Ischemic time: 20 minutes C. The specimen is labeled "AXILLARY LYMPH NODE LEVEL I" and is received unfixed. It consists of two nodular pieces of fatty yellow-tan tissue with metallic staples measuring 2.2 x 1.5 x 0.5 cm in aggregate. On sectioning, there are two lymph nodes measuring 0.7 and 1.0 cm in maximum dimensions. The lymph nodes are entirely submitted in cassette C1.. Time specimen was removed from the patier Time specimen was sectioned and placed in formalin. Ischemic time: 11 minutes. D. The specimen is labeled "LEFT AXILLARY HYDRADENITIS" and is received in formalin. It consists of an unoriented brown ellipse of skin with attached subcutaneous tissue measuring 3.0 x 1.2 x 1.2 cm. There is a central old scar measuring 0.4 x 0.3 cm in maximum dimensions. On sectioning, there is a firm white area measuring 1.0 x 1.0 cm in maximum dimensions beneath the scar. Representative sections are submitted in cassettes D1-D2 scar with firm white area.. Time specimen was removed from the patient: Time specimen was sectioned and placed in formalin:. Ischemic time: 1 minute. Dictated by: Special Stains / Slides 22 H&E Tissue Code Page 4 of 4 Print Date/Time:
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diff --git a/output/text/03368311-f45b-4e6d-addf-d1a1c2676dfb.txt b/output/text/03368311-f45b-4e6d-addf-d1a1c2676dfb.txt
new file mode 100644
index 0000000000000000000000000000000000000000..15de9eddc594a7a7b492c6f9757968099f62ff0a
--- /dev/null
+++ b/output/text/03368311-f45b-4e6d-addf-d1a1c2676dfb.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Icd-0-3 850u|3 Taiicni hisiukt: + DATE of LMP: * DATE OF LAST DELIVERY: * Site Cou: brest, ns C509 PRE-OP DIAGNOSIS: LEFT BREAST CANCER POST-OP DIAGNOSIS: SAME OPERATIVE PROCEDURE: LEFT SEG MAST AND AXILLARY DISSECTION CLINICAL HISTORY: MATERIAL SUEMITTED: A) LEFT AXILLA, PROCUREMENT BY SURGICAL PROCEDURE B) LEFT BREAST BIOPSY/MASS/SEGMENTAL MASTECTOMY, PRCCUREMENT BY SURGICAL PROCEDURE INTRAOPERATIVE CONSULTATION : radiograph. Specimen is received inked and previously sectioned by Dr.. by 1.i cm firm to hard area which is 0.4 cm from the posterior margin and 0.3 cm from the anterior margin; There is a medial 1.8 by 1.5 lateral to this mass is an area of calcification on radiograph. Section thru this area shows ill defined fibrous tissue, approximately 1.2 by 1.0 by 0.8 cm with white punctate tissue, < 0.1 cm. ADDENDA: Addendum MACROSCOPIC DESCRIPTION: BLOCKS B3 AND B8 SUBMITTED FOR ER/PR AND HER-2/NEU FINAL DIAGNOSIS: My signature is attestation that I have personally reviewed the submitted material(s) and the final.. diagnosis reflects that 'evaluation.. ER/PR DMUNOPEROXIDASE IDENTIFICATION OF ESTROGEN AND PROGESTERONE RECEPTORS IS CARRIED OUT ON BLOCKS B3 AND B8 DISTINCT INTRANUCLEAR STAINING IS IDENTIFIED FOR ESTROGEN RECEPTOR (9Ot) AND FOR PROGESTERONE RECEPTOR (60%). THEREFORE, BOTH ARE INTERPRETED AS POSITIVE. HER-2/NEU C-OrbB2 (HER-2/NEU) IMMUNOSTAINING IS CARRIED OUT ON BLOCKS B3 AND B8 (BREAST CANCER) USING A 1:30O DILUTION OF DAKO'S POLYCLONAL ANTIBODY A485 (DIRECTED AGAINST THE INTRACELLULAR DOMAIN OF c-OrbB2) WITHOUT ANTIGEN RETRIEVAL. DISTINCT COMPLETE MEMBRANE STAINING IS IDENTIFIED ONLY RARELY IN 5t OF TUMOR CELLS. THEREFORE, c-S erbB2 (HER-2/NEU) IS INTERPRETED AS NEGATIVE (SCORt 1+). FINAL DIAGNOSIS: FINAL DIAGNOSIS: PREVIOUS REPORTSE A) LEET AXILLARY CONTENTS: ELEVEN (11) LYMPH NODES, NECATIVE FOR METASTATIC CARCINOMA B) LEFT BREAST, SEQMENTAL MASTECTOMY: INEILTRATING MULTIFOCAL.. NOTTINGHAM SCORE FOR BOTH TUMORS - 8/9 (TUBULES - 3, NUCLEAR ATYPIA - 3, MITOTIC INDEX - 2). INKED ANTERIOR MARGIN AND INFILTRATING TUMOR SXTENDS TO WITHIN O.3 CM OF THE ANTERIOR MARGIN LYMPHOVASCULAR PERMEATION IS IDENTIFIED TUMOR AND NON-TUMOR ASSOCIATED MICROCALCIFICATIONS - CHANGES CONSISTENT WITH PREVIOUS BIOPSY - FIBROCYSTIC CHANGES NoTe: Both tumor nodules have similar architactural and cytologic foatures. Nore: ER/pR immunoperoxidase UUID:EEB515A4-4AF3-475B-B6C0-A6134C96480A TCGA-BH-A18K-01A-PR Redacted
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diff --git a/output/text/03502bc8-3b97-42b1-9e61-3396593c66ff.txt b/output/text/03502bc8-3b97-42b1-9e61-3396593c66ff.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4b0495ea0578df49d42c63fe554b65f2dbd7e747
--- /dev/null
+++ b/output/text/03502bc8-3b97-42b1-9e61-3396593c66ff.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+PATHOLOGIC DIAGNOSIS: A/1) RIGHT KIDNEY, RADICAL NEPHRECTOMY: RENAL CELL CARcINOMA, chromophobe type (9.7 cm), Fuhrman nuclear grade 2(of 4), arising in the upper pole. No lymphovascular invasion. Tumor is limited to kidney. Renal artery, vein, ureteral margins are negative for tumor. Immunohistochemistry performed at. demonstrates that the lesional cells are. negative for S-10o-Al. A Halo?s colloidal iron stain is positive in tumor cells. The findings support the above diagnosis. The non-neoplastic kidney will be evaluated by Renal Pathology, and the findings will be reported in an addendum. B/2) SPECIMEN LABELED "REGIONAL RETROPERITONEAL LYMPH NODES": Fibroadipose tissue, negative for tumor. No lymphoid tissue is present (entirety of specimen is submitted). AJcc Classification (6th edition) : T2 NX MX.. CLINICAL DATA: History: None given. Operation: Right radical nephrectomy Clinical Diagnosis: Right renal mass TISSUE SUBMITTED: A/1) Right kidney to tumor bank B/2) Regional retroperitoneal lymph nodes. GROSS DESCRIPTION: The specimen is received fresh, in two parts, each labeled with the patient's name and unit number. Part A, "#1. Right kidney", consists of a radical nephrectomy specimen (460.5 cm x 1.2 cm in diameter), and renal artery (0.8 cm x 0.5 cm in diameter).s Very scant attached perinephric adipose tissue is present.* The specimen is inked black and bivalved. There is a tan, well-circumscribed mass (9.7 x 8.3 x 6.2 cm) arising in the cortex of the upper pole, located 8.5 cm to ureter margin, 1.1 cm to vein margin and 3.2 cm to artery margin and abuts the kidney capsule. On cut sections, there are areas of necrosis and hemorrhage present within the mass. No adrenal gland is identified. A representative section of tumor is submitted for cytogenetics, electron microscopy, and tissue banking. Representative sections of normal appearing kidney is submitted for tissue  bank, EM, and IF. Gross photos are taken and representative sections are submitted for histology. Micro Al: Renal artery vein and ureter margin, en face,. Micro A2: Tumor and adjacent uninvolved cor. 1 frag, Micro  A3: Tumor  and renal pelvis, 1 frag, Micro A4: Tumor and  capsule, 1 frag, Micro A5: Tumor and perirenal fat, frag,
+
+--- Page 2 ---
+Pathology Report Micro A6-A8: Representative sections of tumor, 1 frag each, Micro A9: Tumor quick fix, 1 frag, Rss. Micro Al0: Uninvolved renal cortex, 1 frag, Part B, "#2. Regional retroperitoneal lymph node", consists of one fragment of yellow soft tissue (2.9 x 2.4 x 1.0 cm) which is entirely submitted.. Micro B1-B3: Regional retroperitoneal lymph nodes, 1 frag each, By his/her signature below, the senior physician certifies that he/she personally conducted a microscopic examination ("gross only" exam if so stated) of the described specimen(s) and rendered or confirmed the diagnosis(es) related thereto. ADDENDUM: ,RENAL PATHOLOGY EVALUATION OF THE KIDNEY PARENCHYMA: RIGHT KIDNEY, NEPHRECTOMY: NORMAL. KIDNEY, WITH MINIMAL CHRONIC CHANGES OF THE KIDNEY PARENCHYMA, MOST LIKELY AGE-RELATED (SEE NOTE) NOTE : The kidney parenchyma sample examined shows minimal chronic changes, within the expected range for a  There is minimal focal. global glomerulosclerosis (0.3% of glomeruli), minimal tubular atrophy and interstitial fibrosis (less than 5% of the parenchyma), and no significant vascular sclerosis. MICROSCOPIC DESCRIPTION: Sections of formalin-fixed, paraffin-embedded tissue (Block A1o) were evaluated using H&E, pAs, Jones silver methenamine, and AFog (trichrome) stains. The sample consists of cortex and medulla. There are 326 glomeruli present, of which 1 (0.3%) is globally sclerosed. The remaining glomeruli show no significant expansion of the mesangial areas. There are no discernible craters or double contours of the glomerular capillary wall basement membranes.  Rare distal tubules contain pas-positive hyaline casts... Less than 10% of the. cortical parenchyma shows tubular atrophy and interstitial fibrosis. Arteries and arterioles exhibit no significant sclerosis. Page: 2 of 2
+
+--- Page 3 ---
+KARYOTYPE: Not obtained METAPHASES COUNTED:0 ANALYZED:0 INTERPRETATION: Attempted cytogenetic analysis was unsuccessful because the sample was contaminated upon receipt. No Fish analysis was performed as requested by. INDICATION FOR TEST: ? oncological Rcc
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diff --git a/output/text/03eec11b-b6ae-401d-b203-56fe80e853e4.txt b/output/text/03eec11b-b6ae-401d-b203-56fe80e853e4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1fb1251f37cba42cc86d3447b71226e8678b216e
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+PATHOLOGIC DIAGNOSIS: A.SPECIMEN DESIGNATEDSIGMOID COLONPARTIAL COLECTOMY23.2 Cm ADENOCARCINOMA, LOW GRADE,MODERATELY DIFFERENTIATED (5.8 Cm in greatest dimension). Tumor is located in sigmoid colon, forms a polypoid and fungating mass,is ulcerative, and has an infiltrating border. Tumor invades into the muscularis propria. Proximal, distal, and radial resection margins are negative for tumor. Invasive tumor is 7.5 cm from the closest mucosal resection margin. Lymphovascular invasion is not identified. Extramural venous invasion is not identified. Perineural invasion is not identified. Peritumoral lymphoid response (including Crohn?s-like infiltrate) is not present. Residual adenoma is absent. Regional lymph nodes (positive: total): 0:13 AJcc Classification6th edition): pT2 NO MX. Associated diseases include hyperplastic polyps and diverticulosis. B.SPECIMEN DESIGNATED "PROXIMAL DONUT": Colonic mucosa,negative for tumor. C.SPECIMEN DESIGNATED DISTAL DONUT Colonic mucosa, negative for tunor. CLINICAL DATA: History: Invasive adenocarcinoma. Operation: Sigmoid colectomy. Operative Findings: None given. Clinical Diagnosis: Colon CA. TISSUE SUBMITTED: A/1) Sigmoid colon Tissue Bank open and return) B/2) Proximal donut
+
+--- Page 2 ---
+C/3) Distal donut GROSS DESCRIPTION: The specimen is received fresh, and labeled with the patient's name and medical record number and consists of three parts. Part A,"#1.Sigmoid colon," consists of a segment of colon 23.2 cm in length x 2.8 cm in diameter) with a 3.2 cm open resection margin inked blue and a 3.0 There is a tan/pink centrally cm stapled resection margin inked green. ulcerated polypoid mass (5.8 x 3.6 x 0.9 cm) that is 7.5 cm to the stapled resection margin, and 12.6 cm to the open resection margin. The mass appears to invade the muscularis,but not through the serosa. A section of this mass is representatively submitted to the tissue bank. The radial resection margin is inked black. There is also a tan/pink sessile polyp (0.8 x 0.5 x 0.4 cm) There that is 9.0 cm to the open resection margin and 4.5 cm from the mass. The are four other tan/pink sessile polyps ranging in size from 0.3 to 0.5 cm. closest of which is 1.0 cm to the open resection margin. A portion of normal colonic mucosa is also submitted to the tissue bank. None of the polyps appear to invade into the lamina propria. Micro Al: Stapled resection margin to in potential polyp,1 frag, Micro A2 Open resection margin, 1frag, Micro A3-A6: Representativ ections of the tumor with radial resection margin, 1 frag per block, Micro A7: Polyp #2 that is from the mass,1 frag, Micro A8: Polyp #3,1 frag, Micro A9: Micro Al0: Polyp #5,1 frag, Micro A11-A17: Candidate lymph nodes, multi frags Part B,"#2. Proximal donut, consists of a portion of bowel (1.0 cm in length x 2.l cm in diameter) that is attached to a circular metallic stapling device 2.6 cm in diameter x 5.0 cm in length) The entire portion of bowel which contains no visible lesions is submitted. Micro B1: Entirely submitted specimen, 2 frags, PartC,#3.Distal donutconsists of a portion o f bowel1.9 cmx1.5 x0.9 cm) with no gross lesions. Approximately 80% of the specimen is separable from the staples and is submitted. Micro C1-c2: Distal donut, multi frags, By his/her signature below, the senior physician certifies that he/she personally conducted a microscopic examination ("gross only" exam if so stated) of the described specimen(s) and rendered or confirmed the diagnosis(es) related thereto.
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diff --git a/output/text/04046dc4-31ba-4984-b7f3-8259cb50bb8a.txt b/output/text/04046dc4-31ba-4984-b7f3-8259cb50bb8a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b8956e02fd43f81a639fb1b90ae0e8c15c55019e
--- /dev/null
+++ b/output/text/04046dc4-31ba-4984-b7f3-8259cb50bb8a.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:F57E6E47-4A8E-42C2-ABB8-DD81EF21DBF6 TCGA-YS-A95B-01A-PR Redacted Collect date: (MM/DD/YYYY) PATHOLOGY REPORT: PRIMARY SITE: Pleura Pleural biopsy DD0:3 Malign epithelioid mesothelioma. mmslgnant 9t 5&J 3 S.te: HeuraNS C 38 y J>3/i3/i4 UALIFIED eved23
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diff --git a/output/text/040ca976-b4d4-4500-beac-b4a712962de0.txt b/output/text/040ca976-b4d4-4500-beac-b4a712962de0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5f7876b19abe073a28a957b5dd7e7d6fb951a1e0
--- /dev/null
+++ b/output/text/040ca976-b4d4-4500-beac-b4a712962de0.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+SURGICAI PATHOLOGY REPORT Clinical Diagnosis & History: Colon cancer. Specimens Submitted: 1: SP: COLON; RIGHT HEMICOLECTOMY 2: SP:OMENTUM RESECTION DIAGNOSIS: 1. COLON; KIGHT HEMICOLECTOMY: TUMOR TYPE: ADENOCARCINOMA. - HISTOLOGIC GRADE: MODERATELY DIFFERENTIATED. -TUMOR LOCATION: CECUM. TUMOR SIZE: LENGTH IS 3.2 CM, WIDTH IS 4.4 CM, MAXIMAL THICKNESS IS 1.0 CM.  GROSS CONFIGURATION: POLYPOID. - TUMOR INVASION: INVASION INIO SUBSEKOSA SEROSAL INVOLVEMENT: NOT IDENTIFIED. - VASCULAR INVASION: NOT IDENTIFIED. SURGICAL MARGINS (FOR COLONIC TUMORS) : FREE OF TUMOR. POLYPS (AWAY FROM THE CARCINOMA): NUMBER IDENTIFIED: 3, TYPE IDENTIFIED: TUBULAR ADENOMAS. -NON-NEOPLASTIC BOWEL: UNREMARKABLE. THE PATHOLOGIC STAGE IS (AJCC .: pT3. LYMPH NODES: NUMBER WITH METAST 1, NOMBER EXAMINED: 19. THEPATHOLOGICSTAGE ISAJCC pN1. 2. OMENTUM; KESECTION: I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED OPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Gross Description:. ** Continued on next page.
+
+--- Page 2 ---
+Page 2 of 3 1. The specimen is received fresh, Iabeled "Right hemicolectomy" and consists of a segment of terminal ileum, cecum with attached appendix and ascending colon. "The terminal ileum measures 68 cm in length and 4 cm in circumference at the proximal resected margin. The remaining colon measures 20.1 cm in length with a circumference of i1 cm at the diatal resected margin. The attached appendix measures 6.2 cm in length and averages 0.6 cm in diameter, and has aerosal adhesions. The intestinal serosa is pink tan and smooth. Focally hemorrhagic lobulated yellow tan adipose tissue spang the length of the specimen measuring up to 7.0 cm in thickness. The specimen is opened to reveal a polypoid and focally ulcerated tumor measuring 3.2 cm in length and 4.4 cm in width, 1.5 cm distal to the ileocecal valve, and 1.8. cm from the closeat radial margin. Sectioning shows that the tumor invades into the aubserosal fat. The depth of invasion is I.0 cm grossly. There is. also a 0.8 x 0.8 x 0.4 cm polyp, 1.5 cm diatal to the tumor. The remaining colonic mucosa shows additional polyps, ranging in size from 0.1 to 0.3 cm. The specimen is submitted for lymph node dissection. Multiple lymph nodes are identified in the attached adipose tissue and are submitted. Representative sections of the specimen are submitted for pexmanent aections and for rps. Summary of sectione: P-- proximal margin shave D  diatal margin shave. appendix repres tative sectione tumor RM . radial margin LP largest polyp SP  smaller polyps RS -representative sections, texminal ileum and colon 2. The specimen ir received fresh, labeled "Omentum." It consists of a 27 x. 18 x 2 cm fragment of adipose tissue consistent with omentum. Serial sectioning reveale an unremarkable cut aurface. Representative sections are submitted. Summary of sectione: 0 . omentum Summary of Sections:. Part 1: SP: COLON; RIGHT HEMICOLECTOMY Block Sect. Site PCs A 3 DM 8 LN 26 ** Continued on next page **.
+
+--- Page 3 ---
+md mt r4 md t4  Part 2: SP: OMENTUM; RESECTION Block Sect. Site PCs ** End of Report **
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diff --git a/output/text/04790c46-7a73-4d5f-9994-25eecbca9531.txt b/output/text/04790c46-7a73-4d5f-9994-25eecbca9531.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e179ae6ab36c7d538d7e8390ad0c9cc939e77f15
--- /dev/null
+++ b/output/text/04790c46-7a73-4d5f-9994-25eecbca9531.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+LCD-O-3 UUID:6C9B7DE2-682F-4F4A-8879-159F9989C40C CGCF Carcinsme, Adreua) brtiia) TCGA-OR-A5LT-01A-PR Redacted s3 7dl3 Site:CAdreral Glavd Cortex C74t.d HD q[c/13 Procedure: Left adrenalectomy and left nephrectomy Gross description: Weight of both adrenal and kidney = 1060g. Tumor measures 14 x 13cm. Diagnosis: Carcinoma of adrenal with oxyphilic features (based on Bisceglia et al). Weiss score = 8. Thrombus in renal vein. No lymph node metastasis. Peritoneal fluid contains no malignant cells. w ii|i3
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diff --git a/output/text/049e9450-d220-473f-b622-3600fff8053e.txt b/output/text/049e9450-d220-473f-b622-3600fff8053e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1d9ecaf88d7ec7d06be56ad9df6c719b40ace1ae
--- /dev/null
+++ b/output/text/049e9450-d220-473f-b622-3600fff8053e.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Tss Patient ID: Surgical Date: Gross Description: A solid tumor is located in nearby of the nipple, with 4x3x3.5cm in size, firm with a gray surface, irregular border. Microscopic Description: Tumor cells arrange in diffuse or alveolar, or sheets replace begnin tissue . The tumor cells are composed of large transformed lymphoid cells with very hyperchromatic enlarged  nuclei. Tumor cells are oval or round in shape with defined cytoplasm. Nucleoli is single or multiple. Mitotic figures are commnon. Tumor is invasion of begnin breast tissue. Diagnosis Details: Large B-cell difuse lymphoma. Jener Comments: 9680 B cell Formatted Path Reports: BREAST TISSUE CHECKLISTE 46cr Sute Yueoo+Nos C 50.9 Specimen type: Mastectomy Specimen size: Not specified YEreast,ertiolp C 50.1 Tumor site: Breast JJ 9/3/1 3 Tumor size: 4 x 3 x 3.5 cm UUID:F36A477E-88C9-476A-BF68-61CA129A30A1 Grossly evident lesion: Yes TCGA-FA-A7DS-01A-PR Redacted Histologic type: Diffuse large b-cell lymphoma. Histologic grade: Poorly differentiated Tumor extent: Not specified Lymph nodes: 0/9 positive for metastasis (Axillary 0/9) Extracapsular invasion of the lymph nodes: Not specified Margins: Not specified Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified
+
+--- Page 2 ---
+Total Nottingham Score: Score cannot be determined. Evidence of neo-adjuvant treatment: Not specified. Additional pathologic findings: CKAE1/AE3(-), CD20(+), CD3(-) Comments: Right- central W 8|a1|13|
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diff --git a/output/text/04df74c0-d2d8-4fcb-9d2f-c4f43be02218.txt b/output/text/04df74c0-d2d8-4fcb-9d2f-c4f43be02218.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4e919c578664eddeb72b94f45cb66d34144f2022
--- /dev/null
+++ b/output/text/04df74c0-d2d8-4fcb-9d2f-c4f43be02218.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+SURGICALPATHOLOGYREPORT Patient Name: Accession #: Med.Rec.# Date of Procedure DOB: Date of Receipt Gender: Date of Report Ref.Physician: Account#: Patient Address: Billing Type: Additional Copy to Ref.Source Clinical Diagnosis & History Large left renal mass please correlate with FNA of cervical lymph node Specimens Submitted 1SP:Left kidney,radical nephrectomy 2SP:Hilar lymph nodes,excision 3:SP:Inferior mesentery artery lymph nodes,excision 4:SPPara aortic lymph nodes #1,excision 5:SPPara aortic lymph nodes #2,excision 6SPLeft hilar lymph nodes,excision 7SP:Left adrenal gland,adrenalectomy 8:SP:Mesentary lymph nodes,excision DIAGNOSIS: 1.SP:Left kidney,radical nephrectomy Tumor Type: Renal cell carcinoma-Unclassified type favor collecting duct type (see note) Tumor Size: Two masses identified (15 and 3 cm,respectively) Local Invasion (for renal cortical types) Extends through renal capsule but confined within Gerota's fascia Extends into renal pelvis Involves renal sinus fat Involves renal hilar fat Renal Vein Invasion: Not identified Extensive small vessel and lymphtic invasion identified Surgical Margins: Free of tumor Non-Neoplastic Kidney Unremarkable Adrenal Gland: see parts 6 and 7 Lymph Nodes: Number of metastatic nodes:1 Number of nodes examined:1 Page 1of6
+
+--- Page 2 ---
+SURGICAL PATHOLOGYREPORT Staging for renal cell carcinoma/oncocytoma: pT3a Tumor invades the adrenal gland or perinephric tissues but not beyond Gerota's fascia NOTE: IMMUNOHISTOCHEMICAL STAINS WERE PERFORMED BUT ARE NON-CONTRIBUTORY.BASED ON THE MORPHOLOGIC FEATURES, WE FAVOR THIS TUMOR TO BE OF COLLECTING DUCT ORIGIN (COLLECTING DUCT CARCINOMA).CASE REVIEWED AT THE GENITOURINARY CONSENSUS CONFERENCE 2.SPHilar lymph nodes,excision: Lymph Nodes: Metastatic carcinoma involving adipose tissue, measuring 5.8 cm.No lymphoid tissue identified 3.SP:Inferior mesentery artery lymph nodes,excision: Lymph Nodes: Number of nodes examined:2 Number of metastatic nodes:2 The largest metastatic node is 1.5cm Perinodal (extracapsular) extension not identified 4. SP:Para aortic lymph nodes #1,excision Lymph Nodes: Number of nodes examined:1 Number of metastatic nodes:1 The largest metastatic node is 4.5cm Perinodal (extracapsular) extension not identified 5.SP:Para aortic lymph nodes #2,excision: Lymph Nodes: Number of nodes examined:11 Number of metastatic nodes:11 The largest metastatic node is 6.0cm Perinodal (extracapsular) extension not identified 6. SP:Left hilar lymph nodes,excision LymphNodes: Number of nodes examined:14 Number of metastatic nodes:14 The largest metastatic node is 6.2cm Perinodal (extracapsular) extension not identified Portion of adrenal gland involved by metastatic carcinoma. 7.Left adrenal gland,adrenalectomy: -Metastatic carcinoma involving adrenal gland. 8. SPMesentary lymph nodes, excision: Lymph Nodes: Number of nodes examined:2 Number of metastatic nodes:2 The largest metastatic node is 2.0cm Perinodal (extracapsular) extension not identified Page 2of6
+
+--- Page 3 ---
+SURGICAL PATHOLOGYREPORT NOTE: THIS TUMOR IS COMPATIBLE AS THE PRIMARY SITE OF ORIGINFOR MATERIAL RECEIVED FROM THE PRIOR CYTOLOGY SPECIMENFROM THE LEFT NECKLYMPH NODE IATTEST THAT THE ABOVE DIAGNOSIS IS BASEDUPON MYPERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL).AND THAT IHAVE REVIEWED AND APPROVED THIS REPORT Special Studies: Result Special Stain Comment CK7 CK20 34BE12 CD10 CA-1X. TTF-1 CD117 MUCIN IMMRECUT NEGCONT RACEMASE RECUT RECUT RECUT RECUT RECUT RECUT RECUT RECUT Gross Description: 1) The specimen is received fresh labeled "left kidney" and consists of a kidney with attached ureter,renal vessels and perinephric fat weighing 1478 g in total.The kidney measures 19.5 x 14.0 x 9.0 cm.The attached ureter measures 12cm in length and 0.5 cm in diameter. The attached renal vein measures 2 cm in length and 1.2 cm in diameter.The renal vessels and ureter margins are grossly unremarkable.An adrenal gland is not identified. The kidney is inked black and bivalved to reveal 2 tumors.The first measures 15 x 13 x 12 cm.The second measures 3.0 x2.2x 1.9 cm and is located in the opposite pole.Both have yellow-white cystic and focally hemorrhagic cut surfaces. Sections through the remainder of the kidney reveal a pink brown parenchyma,with a well-defined cortico-medullary junction.The cortex measures 0.6 cm and the calyces appear normal. A 0.5 cm polyp is noted in the renal pelvis. One possible lymph node is identified in the perinephric fat.The specimen is photographed Representative sections are submitted for TPS and for permanent sections. Summary of sections: UVM--ureteral and vessel margins T--tumor THF-- tumor with hilar fat TSF--tumor with sinus fat TK-- tumor with adjacent kidney RP- renal pelvis representative sections (including polyp) T2--smaller tumor K-- representative sections kidney LN-possible lymph nodes 2). The specimen is received fresh,labeled "Hilar lymph node"and consists of an enlarged firm lymph node with scant attached adipose tissue measuring 5.8 x 3.5 x 3.2 cm.on cut section the specimenit shows soft,necrotic. white-tan tumor. Representatives sections are submitted Summary of sections: Page 3 of 6
+
+--- Page 4 ---
+SURGICAL PATHOLOGY REPORT LN-lymph node 3).The specimen is received fresh labeled Inferior mesenteric artery lymph node.It consists of two firm brown-tan lymph nodes measuring 1.0x0.8 x0.4 cm and 1.5 x 1.2x0.8 cm.Larger lymph node is inked black and bisected.Lymph nodes are entirely submitted Summary of sections LN-lymph nodes 4). The specimen is received fresh, labeled "Para-aortic lymph node number one"and consists of a single firm brown-tan lymph node measuring4.0 x2.7 x1.7 cm.Representative sections are submitted.. Summary of sections: LN-lymph node 5).The specimen is received in formalin labeled Paraaortic lymph nodes #2" and consists of multiple pink tan firm lymph nodes with attached fatty fibrous tissue ranging from 0.4 cm up to 6.0 cm in greatest dimension. Lymph node have a white firm papillary cut surface, the remaining lymph nodes are entirely submitted.TPS of the largest positive lymph node is submitted.All identified lymph nodes are submitted. Summary of sections: LN1-grossly positive lymph node LN2- grossly positive lymph node LN3-grossly positive lymph node LN4-grossly positive lymph node LN5-grossly positive lymph node LN6-grossly positive lymph node LN7-grossly positive lymph node LN8-grossly positive lymph node BLN-bisected lymph nodes LN--lymph nodes 6).The specimen is received in formalin labeled "Left hilar lymph nodes" and consists of multiple pink tan firm lymph nodes with attached fatty fibrous tissue ranging from 0.3 cm up to 6.2 cm in greatest dimension.Lymph node have a white firm papillary cut surface,the remaining lymph nodes are entirely submitted. TPS of the largest positive lymph node is submitted.All identified lymph nodes are submitted. Summary of sections: LN1-grossly positive lymph node LN2-grossly positive lymph node LN3-grossly positive lymph node LN4-grossly positive lymph node LN5-grossly positive lymph node LN6-grossly positive lymph node LN7-grossly positive lymph node LN8-grossly positive lymph node LN9-grossly positive lymph node LN10-grossly positive lymph node LN11-grossly positive lymph node Page4of6
+
+--- Page 5 ---
+SURGICAL PATHOLOGY REPORT BLN-bisected lymph nodes LN-lymph nodes 7).The specimen is received in formalin labeled Left adrenal glandand consists of a 8 x 5x 3 cm portion of tan fibrofatty tissue which weighs 47grams.The specimen is inked black.On cut section a 3.7 x3 x 2.5cm orange adrenal bland is identified .There is a markedly, indurated, fleshy,hemorrhagic area, measuring 1.4 x 0.6 x 1cm located on the peripheral of the gland The remaining parenchyma reveal firm, orange glandular cut surface.No lymph nodes are identified on the peri-adrenal fat.Representatively submitted. Summary of sections: RS-representative sections 8). The specimen is received in formalin,labeled "Mesenteric lymph node" and consists of a single white tan firm positive lymph node measuring2 x 1.2 x 0.8 cm.The lymph node is bisected and entirely submitted Summary of sections: BLN-bisected a lymph node Summary of Sections: Part 1:SP:Left kidney,radical nephrectomy Block Sect.Site PCs 1 k 1 1 In 1 1 rp 1 10 t 10 3 t2 3 1 thf 1 1 tk 1 1 tsf 1 1 um 1 1 vm 1 Part 2:SP:Hilar lymph nodes,excision Block Sect.Site PCs 1 LN 1 Part 3:SP:Inferior mesentery artery lymph nodes,excision Block Sect.Site PCs 1 LN 1 Part 4:SP:Para aortic lymph nodes #1,excision Block Sect.Site PCs 1 In 1 Part 5:SP:Para aortic lymph nodes #2,excision Block Sect.Site PCS 3 bln 3 1 In 1 1 In1 1 1 In2 1 In3 1 Page 5of6
+
+--- Page 6 ---
+SURGICAL PATHOLOGYREPORT 1 In4 1 1 In5 1 1 In6 1 1 In7 1 1 In8 1 Part 6:SP:Left hilar lymph nodes,excision Block Sect.Site PCs 3 bin 3 2 In 2 1 In1 1 1 In10 1 In11 1 in2 1 1 1 In3 1 1 In4 1 1 In5 1 yae In6 1 In7 1 1 In8 1 1 In9 1 Part 7:SP:Left adrenal gland,adrenalectomy Block Sect.Site PCs 5 RS 5 Part 8:SP:Mesentary lymph nodes,excision Block Sect.Site PCs 2 BLN 3 Page 6of6 ENDOFREPORT
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diff --git a/output/text/04f2d9f2-643f-46ac-af5a-7ecb0f475aa5.txt b/output/text/04f2d9f2-643f-46ac-af5a-7ecb0f475aa5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0049b82eb9924261e7501edcc128bec3ee80850b
--- /dev/null
+++ b/output/text/04f2d9f2-643f-46ac-af5a-7ecb0f475aa5.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SPECIMENS: A. TUMOR BED LEFT PARTIAL NEPHRECTOMY B. LEFT PARTIAL NEPHRECTOMY SPECIMEN(S): A. TUMOR BED LEFT PARTIAL NEPHRECTOMY B. LEFT PARTIAL NEPHRECTOMY DIAGNOSIS: A. KIDNEY, LEFT, TUMOR BED BIOPSY: - NEGATIVE FOR MALIGNANCY B. KIDNEY, LEFT, PARTIAL NEPHRECTOMY: - RENAL CELL CARCINOMA, PAPILLARY TYPE  FUHRMAN NUCLEAR GRADE 2 TUMOR SIZE: 6.2 X 6 X 5.3 CM - SURGICAL MARGIN PSITIVE (FOCAL: 1MM) - NO VASCULAR INVASION IDENTIFIED - TUMOR LIMITED TO THE KIDNEY SYNOPTIC REPORT - KIDNEY (PARTIAL OR RADICAL) Specimens Involved SpecimenS: A: TUMOR BED LEFT PARTIAL NEPHRECTOMY B: LEFT PARTIAL NEPHRECTOMY Specimen Type: Partial nephrectomy Without adrenal gland Laterality: Left Tumor Site: Not specified Focality: Unifocal Tumor Size (largest tumor if multiple): Greatest dimension:. 6.2cm Additional dimensions: 6cm x 5.3cm Macroscopic Extent of Tumor: Tumor limited to kidney. WHO CLASSIFICATION Papillary renal cell carcinoma 8260/3 Histologic Grade (Fuhrman Nuclear Grade): G2: Nuclei slightly irregular, approximately 15 u; nucleoli evident  Invasion of Vascular/Lymphatic: Absent Perinephric Tissue Invasion: Absent Margins: Margin(s) involved by invasive carcinoma Include:  Renal parenchymal margin (partial nephrectomy only). Distance: 0cm Adrenal Gland: Not present Regional Lymph Nodes:. None sampled Additional Findings: None identified Pathological Staging (pTNM):  pT 1b N X M X Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition pMX: Cannot be assessed GROSS DESCRIPTION: A. TUMOR BED LEFT PARTIAL NEPHRECTOMY Received fresh labeled with the patient's identification and designated "tumor bed, left partial. nephrectomy" is a fragment of tan fibrous tissue measuring 0.3 x 0.3 x 0.2 cm. Entirely submitted for frozen section, FSA. B. LEFT PARTIAL NEPHRECTOMY Received fresh labeled with the patient's identification and designated "left partial nephrectomy" is an. intact, unoriented, partial nephrectomy specimen, 6.5 x 6 x 5.3 cm, with detached fragment of adipose. tissue, 13.2 x 4.5 x 2 cm, collectively weighing 104 g. The parenchymal margin inked black, remainder of kidney specimen inked blue. The kidney is sectioned to show an encapsulated, golden tan, lobulated,. soft friable mass measuring 6.2 x 6 x 5.3 cm, approaching the parenchymal margin at distance of 0.3
+
+--- Page 2 ---
+cm. The fragment of adipose tissue is sectioned to show unremarkable cut surface. Gross photographs are taken. A portion of the specimen is submitted for tissue procurement, representatively submitted: B1-B5: Representative sections, mass and parenchymal margin B6-B9: Representative sections, mass B10: Representative sections, detached fragment adipose tissue CLINICAL HISTORY: None given PRE-OPERATIVE DIAGNOSIS: Left renal mass FROZEN SECTION INTRAOPERATIVE REPORT: FSA: Soft tissue, tumor bed, biopsy: Fibroadipose tissue defer to permanent Diagnosis called at Gross Dictation:, Final Review:, Pathologist, Final: Pathologist
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diff --git a/output/text/04f4f1f6-a9d4-4777-8956-087206d13196.txt b/output/text/04f4f1f6-a9d4-4777-8956-087206d13196.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6d167b95a4cf6da83d96735a5e0f84cd3d557df7
--- /dev/null
+++ b/output/text/04f4f1f6-a9d4-4777-8956-087206d13196.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:F0519EDE-C458-43C6-BD3F-4E67059E8FCE TCGA-B1-A470-01A-PR Redacted Collection Date: FINAL DIAGNOSIS: Kidney, RIght, ParTial NephreCtomy--  PAPILLARy RENAl CELl CARCINOMA, FAVOR TYPe 2, mAximAl FUHRmAn nUCLEAR GRADe 3 OUt OF 4, SeE COMmenT. TUMOR iS LIMITeD TO THE KIDNEY AND MEASURES 5.6 x 5.0 x 4.0 CM. C. ALL SURGICAL MARGINS ARE FREE OF TUMOR. 'NO VASCULAR INVASION' IS IDENTIFIED E. .PATHOLOGIC TNM STAGE: pT1b NX MX F. PERITUmORAL NON-NEOPLASTIC KIDNEY WITH INTERSTITIAL INFLAMMATION AND SCATTERED SCLERO'TC GLOMERULI. COMMENT: The tumor cells show prominent eosinophilla and focai areas of necrosis. The Fuhrman nuclear grade ranges bet/ean 2. and 3. Some of the Fuhrman grade 2 areas with fbrohistlocytic cores resemble type 1 paplllary renal cell carcinonia, ! ut overall a dlagnosis of type 2 papillary renal cell carcinoma is favored. Immunohistochemical stains are performed with adequate controls and demonstrate that the tumor cells are strongly. positlve for p504s and AE1/3 and show focat / patchy positivity forCK7, CA9, and EMA. These findings support the above diagnosis. CASE SYNOPSIS: SYNOPTIC DATA - PRIMARY KIDNEY TUMORS SPECIMEN TyPE: Partial nephrectomy LATERALITY: Right TUMOR SITE: Not specified FOCALITY: Unifocal TUMOR SIZE: Greatest dimension: 5.6 cm Additional dimensions: 5.0 x 4.0 cm MACROSCOPIC EXTENT OF TUMOR: Tumor llmited to kidney HIstoLOgic type: Papllary renal cell carcinoma HISTOLOGIC GRADE (Fuhrman Nuclear Grade): G3 PATHOLOGIC STAGING (pTNM): pT1b pNX  Number of regional tymph nodes examined: 0 pMX MARGINS: Margins uninvolved by invasive carcinoma ADRENAL GLAND: Not present LYMPH-VASCULAR INVASION (LVl): Absent/not identified ADDITIONAL PATHOLOGIC FINDINGS: None identified 1co-0 :3 8 3k01 3 caucnomn, Papi Hary Nnd cll
\ No newline at end of file
diff --git a/output/text/04fe90f7-5b74-4ee3-bff6-37053a42ae50.txt b/output/text/04fe90f7-5b74-4ee3-bff6-37053a42ae50.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a19b8364494117bbc0ee13701541e3406cc8db4f
--- /dev/null
+++ b/output/text/04fe90f7-5b74-4ee3-bff6-37053a42ae50.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+1cs-0-3 (w/ ptpi l/eny) Sits . Breest nos c50.9 3/1 page 1 / 2 Department of Cancer Pathology . copy No. Date: Examination: Histopathological examination Internal invoice No. Cost of diagnostic procedure Examination No. Age: Gender: . Material: Multiple organ resection - left breast. Unit in charge Physician in charge: Material collected on: Material received or Expected time of examination: up to 8 working days Clinical diagnosis: Cancer of the left breast.  Examination performed on Results of immunohistochemical examination: Estrogen receptors found in over 75% of neoplastic cell nuclei.. Progesterone receptors found in over 75% of neoplastic cell nuclei.. HER2 protein stained with HercepTestTM by Score = 2+, verification by the FIsH method recommended.. Compliance validated by: Examination performed on: Macroscopic description: Left breast sized 26 x 20 x 5.5 cm removed along with axillary tissues sized 10 x 8 x 2.5 cm and a 25 x 14 cm skin. flap. Tumour sized 2.6 x 2 x 1.8 cm found in the outer lower quadrant, 5.3 cm from the lower boundary, 1.2 cm  from the base and 1.4 cm from the skin. Microscopic descriotion: Carcinoma ductale partim papillare - NHG1 (2 + 2 +3/22 mitoses/ 10 HPF, visual area diameter: 0.55 m).. Glandular tissue showing lesions of the type fibrosa et cystica, hyperplasia ductalis simplex Invasive lesions reaching the base. Axillary lymph nodes: Lymphonodulitis chronica et lymphonodorum No xV. Compliance validated by: UUID:72AF26A2-FAD0-42FD-A63C-6E8E2597B84E TCGA-D8-A1JT-01A-PR Redacted 24/
+
+--- Page 2 ---
+page 2 / 2 Examination: Histopathological examination (. Examination No. Gender Patient: xXx Examination performed on: Results of immunohistochemical examination: HER2 DNA Probe Kit  RESULT OF HER2/neu GENE AMPLIFICATION with the FISH method by FINAL RESULT: HER-2 gene AMPLIFICATION NOT FOUND. Histooathological diagnosis: I. Fibrocystic Mixed ductal and papillary invasive carcinoma of the left breast. Usual ductal hyperplasia ( changes. Lymph nodes negative for cancer.. Compliance validated by:
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diff --git a/output/text/050b38eb-d3ac-40fc-880b-59542058be6b.txt b/output/text/050b38eb-d3ac-40fc-880b-59542058be6b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..33a5ad3e2d9ca2b0f239fd482009b099c7d357dd
--- /dev/null
+++ b/output/text/050b38eb-d3ac-40fc-880b-59542058be6b.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+*** Diagnosis/Diagnoses: *** 16-cm long large bowel resection specimen including a polypoid, moderately differentiated adenocarcinoma of the colorectal type with infiltration of the pericolic fatty tissue and with three regional lymph node metastases. Tumor-free large bowel resection margins. Tumor-free mesenteric resection margin. An inflammatory portion of the urinary bladder fused with the large bowel and a ductus deferens segment, adhering in the tumor area.. Tumor stage: pT3 pN1 (3/43) pMX; G2, L0 V0, local R0
\ No newline at end of file
diff --git a/output/text/05365a0d-efe3-4a77-83c7-312f98933284.txt b/output/text/05365a0d-efe3-4a77-83c7-312f98933284.txt
new file mode 100644
index 0000000000000000000000000000000000000000..291ad627cec11a5b93d9af408f53926e45a574fa
--- /dev/null
+++ b/output/text/05365a0d-efe3-4a77-83c7-312f98933284.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+UUID:9C971870-BA92-4E0C-9861-31C56B7E7D640 TCGA-EW-A6SA-01A-PR Redacted LcD-o-3 'arcmning, iyyiltatig duct 85bo/3 V Sute CAc r= Surgical Pathology Report O Yroxt xos c5o.9 -- Case #: Name: XX Pa# OBuset, ento!pntin MRN: XX c 5S.1 Gender: M DOB: Q) 7/24/13 Location: xx Collected: Received: xx -FINAL DIAGNOSIS A. SENTINEL NODE NO.1 COUNT NO ISOLATED TUMOR CELLS in one lymph node (1/1) Immunohistochemistry for keratin confirms the diagnosis. B. SENTINEL NODE NO.2 COUNT NO.. Negative for carcinoma one lymph node (0/1). Immunohistochemistry for keratin performed on 2 slides (BFS1, BFS2) confirms negative for cancer. C. SENTINEL NODE NO.3 COUNT NO Negative for carcinoma one lymph node (0/1).. Immunohistochemistry for keratin performed on 2 slides (CFS1, CFS2) confirms negative for cancer. D. SUSPICIOUS NODE: Negative for carcinoma one lymph node (0/1). Immunohistochemistry for keratin performed on 2 slides (DFS1, DFS2) confirms negative for cancer. E. LEFT BREAST:
+
+--- Page 2 ---
+INVASIVE DUCTAL CARCINOMA, poorly differentiated, Nottingham grade 3 (2+3+3=8), 2.1 cm. DUCTAL CARCINOMA IN SITU, high nuclear grade (DIN 3), solid type, associated with necrosis. Surgical resection margins are free of invasive carcinoma, <0.5 mm from inked deep margin. Previous biopsy site identified. Unremarkable skin and nipple. AJCC Staging: pT2, (sn)pN0(i+), pMn/a See Cancer Case Summary Surgical Pathology Cancer Case Summary: INVASIVE CARCINOMA OF THE BREAST: Procedure: Total mastectomy (including nipple and skin) Lymph Node Sampling: Sentinel lymph nodes Specimen Laterality: Left Tumor Site: Invasive Carcinoma: Central (posterior to nipple) Histologic Type of Invasive Carcinoma:  Invasive ductal carcinoma (no special type or not otherwise specified) Tumor Size: Size of Largest Invasive Carcinoma: Greatest dimension of largest focus of invasion >1 mm: 21 mm Histologic Grade: Nottingham Histologic Score: Glandular (Acinar)/Tubular Differentiation: Score 2: 10% to 75% of tumor area forming glandular/tubular structures Nuclear Pleomorphism: Score 3: Vesicular nuclei, often with prominent nucleoli, exhibiting marked
+
+--- Page 3 ---
+variation in size and shape, occasionally with very large bizarre forms Mitotic Rate: Score 3 (greater than or equal to 8 mitoses per mm2) Overall Grade:. Grade 3: scores of 8 or 9 Tumor Focality: Single focus of invasive carcinoma. Ductal Carcinoma In Situ (DCIS): DCIS is present Negative for extensive intraductal component (EIC) Size (Extent) of DCIS: Estimated size (extent) of DCIS: at least 2.5 mm Number of blocks with DCIS: 2 Number of blocks examined: 8. Architectural Patterns: Solid Nuclear Grade: Grade III (high) Necrosis: Present, focal (small foci or single cell necrosis). Lobular Carcinoma In Situ (LCIS): Not identified Margins: Invasive Carcinoma: Margins uninvolved by invasive carcinoma Distance from closest margin: <0.5 mm Specify margin: Deep DCIS: Margins uninvolved by DCIS Lymph Nodes: Number of sentinel lymph nodes examined: 4 Total number of lymph nodes examined (sentinel and nonsentinel): 4 Number of lymph nodes with isolated tumor cells: 1 Number of lymph nodes without tumor cells identified: 3.
+
+--- Page 4 ---
+Extranodal Extension: Not identified Method of Evaluation of Sentinel Lymph Nodes: Hematoxylin and eosin (H&E), 1 level. Immunohistochemistry Treatment Effect: Response to Presurgical Therapy: In the Breast: No known presurgical therapy In the Lymph Nodes: No known presurgical therapy Lymph-Vascular Invasion Not identified Dermal Lymph-Vascular Invasion: Not identified Pathologic Staging (based on information available to the pathologist) (pTNM) Primary Tumor (Invasive Carcinoma)(pT): pT2: Tumor > 20 mm but < or equal to 50 mm in greatest dimension Regional Lymph Nodes:. Modifier: sn: Only sentinel nodes evaluated. Category (pN) pN0 (i+): Malignant cells in regional lymph nodes no greater than 0.2 mm and no more than 200 cells Distant Metastasis (pM) Not applicable Ancillary Studies: Performed on another specimen Estrogen Receptor (ER): Positive Immunoreactive tumor cells present. Quantitation: >50% Progesterone Receptor (PgR): Negative (<1% of tumor cells with nuclear positivity) HER2: Immunoperoxidase Studies Negative (Score 0)
+
+--- Page 5 ---
+Electronically Signed Out by:. xX, NOTE: Some immunohistochemical antibodies are analyte specific reagents (ASRs) validated by our laboratory (Her 2, Parvo, H. pylori, HBcore) . These ASRs are clinically useful indicators that do not require FDA approval. These clones are used: ID5=ER, PgR 636=PR, A485=HER2, H-11=EGFR, CCH2/DDG9=CMV, F39.4.1=AR and HPV by ISH. All immunohistochemical stains are used with formalin or molecular fixed, paraffin embedded tissue. Detection is by The results are read by a. pathologist as positive or negative.. -Intraoperative Consultation- A. SENTINEL NODE NO.I COUNT NO. (FS): Negative for carcinoma.. B. SENTINEL NODE NO.2 COUNT NO. (FS): Negative for carcinoma.. C. SENTINEL NODE NO.3 COUNT NO. (FS): Negative for carcinoma D. SUSPICIOUS NODE (FS): Negative for carcinoma. XX,mD -Gross Description A. Received fresh and labeled 3SENTINEL NODE NO.1 COUNT NO (FS)4 is a yellow, fibrofatty tissue. Lymph node is identified measuring 2.0 x 0.8 x 0.3 cm. Bisected and submitted in toto in one cassette for frozen section. B. Received fresh and labeled 3SENTINEL NODE NO.2 COUNT NO. (FS)4 is a yellow fibrofatty tissue. Lymph node is identified measuring 1.5 x 0.5 x 0.3 cm. Bisected and submitted in toto in one cassette for frozen section. Cassette 2 remainder of specimen in one cassette. C. Received fresh and labeled 3SENTINEL NODE NO.3 COUNT NO. (FS)4 is a yellow fibrofatty tissue. Lymph node is identified measuring 1.0 x 1.0 x 0.3 cm. Bisected and submitted in toto in one cassette for frozen section. Cassette 2 is remainder of fibrofatty tissue in one cassette. D. Received fresh and labeled 3SUSPICIOUS NODE (FS)4 is a lobulated fibrofatty tissue. One lymph node is identified measuring 2.3 x 1.0 x 0.4 cm. Bisected and submitted in one cassette for frozen section. Cassette 2 remainder of specimen in toto..
+
+--- Page 6 ---
+E. Received in formalin and labeled 3LEFT BREAST / 1 SHORT STITCH SUPERIOR; 1 LONG STITCH LATERAL (FRESH)4 is a lumpectomy specimen oriented with two sutures by surgeon as dictated. Specimen is inked as follows: superior,. blue; inferior, green; deep, black; lateral, orange; medial, red. Specimen. measures from medial to lateral 14.0 cm, superior to inferior 13.0 cm and anterior to posterior 2.2 cm. The specimen weighs 103.0 grams. Sectioning reveals a firm, well defined tan nodule identified with a metallic clip. The nodule measures 2.1 cm medial to lateral, 2.0 cm from superior to inferior and 1.5 cm from anterior to posterior. The closest inked margin is the deep margin,. 0.1 cm. The other margins are as follows: 0.5 cm from superior, 0.5 cm from. inferior, 1.2 cm from lateral, 2.5 cm from medial, 0.1 cm from deep and is covered in the anterior aspect by the overlying skin. There is a segment of dark. brown skin ellipse with nipple measuring 6.5 x 2.5 cm overlying the lesion.. Specimen submitted in cassettes as follows:. 1 Section through the lesion in the superior to inferior direction with. deep margin 2&3 Composite of the lesion in relation with deep margin, inferior and superior margin and overlying skin 4 Additional section of the lesion 5 Additional section of the lesion around the nipple area. 6 Additional section of the lesion 7 Section through the nipple 8 Representative section of the medial and lateral margin. XX, MD (Resident) Clinical History:. Left male breast cancer Pre Operative Diagnosis: Not provided Operation: Left breast total mastectomy, sentinel node biopsy, possible axillary  dissection, possible internal mammary sentinel node biopsy. Specimen(s) Received: A: SENTINEL NODE NO.1 COUNT NO. (FS) B: SENTINEL NODE NO.2 COUNT NO. (FS) C: SENTINEL NODE NO.3 COUNT NO. (FS) D: SUSPICIOUS NODE (FS) E: LEFT BREAST / 1 SHORT STITCH SUPERIOR; 1 LONG STITCH LATERAL (FRESH) 1917
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diff --git a/output/text/053f63b4-d7ca-464c-9ced-f17be839866a.txt b/output/text/053f63b4-d7ca-464c-9ced-f17be839866a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..112b29f3fb882b97261a8e01ed69bca7752d475d
--- /dev/null
+++ b/output/text/053f63b4-d7ca-464c-9ced-f17be839866a.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+UUID: 5A6C1998-43D6-4E70-862B-1D3E81736862 TCGA-CQ-A4CE-01A-PR Redacted Department of Pathology Patient Name Copath # MRN :  Service: Otolaryngology Collected: DOB: Visit #: Resulted:  Gender: Location: HCN : Facility: Ordering MD: Jcs-o -3 Surgical Pathology Consultation Report Nes 8071f3 Sit: tongu, ros c0s.9 SPECIMEN(S) RECEIVED 1. Oral-Cavity: Posterior Margin of Tongue hw 7/>u/1> 2. Oral Cavity :Right lateral tongue floor of mouth 3. Oral Cavity ;left lateral tongue floor of mouth 4. Oral Cavity :Deep posterior tongue margin 5. Oral Cavity :Dorsum of Tongue Right floor of mouth 1single stitch anterior 2 double Iong posterior 1 single short lateral. 6. Neck :Right neck contents 7. Neck ;left neck contents 8. Soft Tissue :Right external jugular tissue DIAGNOSIS 1. Posterior margin of tongue.. Squamous mucosa with chronic inflammation and reactive changes.. Negative for high-grade dysplasia or carcinoma. 2. Right lateral tongue floor of mouth. Squamous mucosa negative for tumor. 3. Left lateral tongue floor of mouth. Squamous mucosa negative for tumor. 4. Deep posterior tongue margin. Skeletal muscle negative for tumor. Oral cavity; dorsum of tongue and right floor of mouth.. Keratinizing squamous cell carcinoma, moderately differentiated.. (please see comment) a. Maximum tumor diameter 3.4 cm.. b. Tumor thickness 1.6 cm. Positive for perineural invasion. C. d. Negative for lymphovascular invasion. e. The posterior and deep margins are positive for tumor.  The remaining margins are negative.
+
+--- Page 2 ---
+Status: complete Copath # Patient Name Service: Otolaryngology Collected: MRN: DOB: Visit #: Resulted: Gender: Location: HCN: Facility: Ordering MD: Right neck contents. 6. Twenty-seven lymph nodes negative for tumor (0/27).. Submandibular gland with no pathologic changes.. 7. Left neck contents. Ten lymph nodes negative for tumor (o/io). Submandibular gland with no pathologic changes.. 8. Right external jugular tissue. Soft tissues with no pathologic changes.. Negative for tumor. COMMENT Two of the specimen margins (specimen 5) are positive for tumor; however, the separately submitted patient's margins were negative (see specimens. 1-4). SYNOPTIC DATA Clinical History: No neoadjuvant therapy Specimen: Dorsal surface of tongue, NoS. Received: Fresh Procedure: Glossectomy: dorsum of tongue right. floor of mouth Neck (lymph node) dissection: right. and left neck Specimen Integrity: Intact Specimen Size: Greatest dimension: 4.2 cm Additional dimension: 3 cm Additional dimension: 1.8 cm Specimen Laterality: Right Tumor Site: Dorsal surface of tongue, Nos. Tumor Focality: Single focus Tumor Size: Greatest dimension: 3.4 cm
+
+--- Page 3 ---
+Tumor Thickness (pr1 and pT2 tumors): Tumor thickness: 16 mm Tumor Description:. Exophytic, Endophytic Histologic Type:. Squamous cell carcinoma, conventional Histologic Grade:s G2: Moderately differentiated Margins: Margins uninvolved by invasive Status: complete Page: 2 of 5 Patient Name. Copath # MRN: Service: Otolaryngology Collected: DOB: Visit #: Resulted: Gender: Location: HCN: Facility: Ordering MD: carcinoma Distance from closest margin: 0.1 cm Margin(s): SEE COMMENT Margin status for carcinoma in situ is not applicable Treatment Effect: Not identified Lymph-Vascular Invasion: Not identified Perineural Invasion: Present Lymph Nodes, Extranodal Extension: Not identified TNM Descriptors: Not applicable Primary Tumor (pT): pT2:Tumor more than 2 cm but not more than 4 cm in greatest dimension Regional Lymph Nodes (pN):. pNO: No regional lymph node. metastasis Number of regional lymph nodes examined: 37 Number of regional lymph nodes involved: 0 Distant Metastasis (pM): Not applicable *Pathologic Staging is based on AJcc/uicc TNM, 7th Edition ELECTRONICALLY VERIFIED BY:
+
+--- Page 4 ---
+CLINICAL HISTORY Tongue CA GROSS DESCRIPTION 1. The specimen is labeled with the patient's name and as "posterior margin of tongue". It consists of a fragment of tissue measuring 1.7 x 0.2 x 0.2 cm. The specimen is submitted in toto for frozen section. 1A frozen section control 2.  The specimen is labeled with the patient's name and as "right lateral tongue floor of mouth". It consists of a fragment of tissue measuring 1 Page: 3 of 5 Status: complete Copath # Patient Name MRN: Service: Otolaryngology Collected: DOB: Visit #: Resulted:. Gender : Location: HCN: Facility: Ordering MD: x 0.5 x 0.2 cm. The specimen is submitted in toto for frozen section. 2A frozen section control 3. The specimen is labeled with the patient's name and as "left lateral. tongue floor of mouth". It consists of a fragment of tissue measuring 0.6 x 0.4 x 0.3 cm. The specimen is submitted in toto for frozen section. 3A frozen section control 4. The specimen is labeled with the patient's name and as "deep posterior tongue margin". It consists of 2 fragments of tissue measuring 1 x 0.6 x 0.3 and 0.4x 0.3x0.2 cm. The specimen is submitted in toto for frozen section. 4A frozen section control 5. The specimen is labeled the patient's name and as "dorsum of tongue right floor of mouth 1 single stitch anterior 2 double long posterior 1 single short lateral". It consists of an oriented portion of tongue. measuring 1.8 SI x 3 ML x 4.2 AP cm. There is a raised tumor involving the dorsal surface of the tongue. The tumor measures 1.6 sI x 2.8 ML x 3.4 AP cm. The tumor is homogeneous and partly friable. It is located at 0.3 cm from the lateral margin (double short suture), 0.7 cm from the.
+
+--- Page 5 ---
+medial margin (opposite to double short), less than 0.1 cm from the deep margin, 0.2 cm from the anterior margin, and close to the posterior. margin. Representative sections are submitted. 5A anterior margin. 5B posterior margin. 5C double short suture margin 5D opposite margin of double short 5E tumor and deep margin 5F tumor 6. The specimen labeled with the patient's name and as "right neck. contents". It consists of an oriented left neck dissection with overall dimensions of 18 x 3 x 1 cm. There is a diagram indicating levels I-Iv.. The submandibular gland measures 2.5 x 3 x 1 cm and is unremarkable.. Multiple lymph nodes ranging from 0.2 to 1.2 cm are identified in multiple levels. Representative sections are submitted. 6A submandibular gland 6B level I, multiple lymph nodes 6C level II, one lymph node Status: complete. Page: 4 of 5 Patient Name Copath #: MRN: Service: Otolaryngology Collected:  DOB: Visit #: Resulted: Gender: Location: HCN : Facility: Ordering MD: 6D-6E level III, multiple lymph nodes 6F level Iv, multiple lymph nodes 6G level Iv, four lymph nodes 6H level IV, multiple lymph nodes 7. The specimen is labeled with the patient's name and as "left neck contents". It consists of an oriented left neck dissection with overall dimensions of 11 x 6 x 1.2 cm.  There is a diagram indicating levels I-Iv. The submandibular gland measures 2.5 x 3 x lcm and is unremarkable. Multiple lymph nodes ranging from 0.3 to 1.3 cm are. identified in multiple levels. Representative sections are submitted. 7A submandibular gland 7B level I, multiple lymph nodes 7C level II, one lymph node bisected 7D level III, 2 lymph nodes 7E level Iv multiple lymph nodes
+
+--- Page 6 ---
+8. The specimen is labeled with the patient's name and as "right measuring 1.8 x 1.5 x 0.2 cm. The specimen is submitted in toto. 8A vessel 8B remaining tissue QUICK SECTION 1-4. Margins (posterior tongue, right lateral tongue/floor of mouth, left. lateral tongue/floor of mouth and deep posterior tongue).. - Negative for malignancy.. Called at Page: 5 of 5 Status: complete ase is(circle):
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diff --git a/output/text/055a22cf-94d5-48a9-8920-66a23c93d9d3.txt b/output/text/055a22cf-94d5-48a9-8920-66a23c93d9d3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c3eb9849b75f46fb8fdceda8f1fae4885b08c84c
--- /dev/null
+++ b/output/text/055a22cf-94d5-48a9-8920-66a23c93d9d3.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+FinalReport DIAGNOSIS:1) TONSIL, LEFT, BIOPSY: MODERATELY TO POORLY DIFFERENTIATED INVASIVE SQUAMOUS CELL CARCINOMA. CLINICAL DATA Clinical Features: unspecified Operation: unspecified Operative Findings: unspecified Operative Diagnosis: : unspecified Tissue Submitted: 1left tonsil GROSS DESCRIPTION: 1) SOURCE: Tonsil, Left. Received fresh is a 5 x 3 x 2 mm piece of tan-white hemorrhagic softtissue labeled left tonsil. The specimen is bisected and placed in one cassette and submitted en toto. Summary of sections: 1A, 2/1. Slides and report reviewed by Attending Pathologist.
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diff --git a/output/text/055bed26-6f82-49b5-affa-d5c1c1b293f5.txt b/output/text/055bed26-6f82-49b5-affa-d5c1c1b293f5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f7feec6add3937d4cddd8d52cf1469ab2f43eccc
--- /dev/null
+++ b/output/text/055bed26-6f82-49b5-affa-d5c1c1b293f5.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+1CD-0-3 Carcinoma hepato cellular, Nos 817o/3 Sin: lwu coa.o 1ps|n h # Pathology Form Specimen Information Collected by: Date: Preserved by: Date me: ESPEcMNxPE(#ofsamplspovidedxata Frozen Paraffia Block  Biood/Serum/Piasma Slide Diseased Normal Diseased  Normal Diseased Normal Diseased Normal 4 2 4 2 4 Time to LN2 Time to Formalin Time to LN2 12 min 3 min min  ASABESPPATHOLOGIGAEDESCRIRTIONESKEA T Primary Tumor Organ Size Extension of Tumor Distance to NAT JiveB JumeR Hot liciR Dxg x6 cm 6 cm Lymph Nodes. Location # Examined # Metastasized Distant Metastasis Organ Detailed Location Size Pathological Staging pT 3 N o M O Stage: Notes: UUID:65D669CE-291F-489A-9B25-AD619B906900 riterla Redacted iagnosis Disc TCGA-CC-A123-01A-PR ror Mah
+
+--- Page 2 ---
+Microscopic Description Ceil Distribution Structural Patterm + Diffuse  Streaming Mosaic  Storiform Necrosis Fibrosis  Lymphocytic Infiltration Palisading Vascular Invasion Cystic Degeneration Clusterized  Bleeding Alveolar Formation  Myxoid Change Indian File  Psammoma/Cakcification EestekcelluarDinerentonssesc Squamous +- Adenomatous  Sarcomatous +- Lymphomatous +  Squamoid Cell Glandular cell Round Cell Large Cell Spindle Cell  Cell Stratification  Fibroblast Small Cell  Keratin Secretion Osteoblast RS Cell/RS Like Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell Pear!  Gland formation Myoblast Plasma Cell Cellular Differentiation:d Well Moderate   Poor wNudeakAppearanceakawrerhssy Nuclear Atypia: 0 1 II III Aniso Nucleosis ? Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity Nuclear Grade: Marker Result Value Date ER  Negative Positive PR  Negative  Positive Her-2/neu  Negative  Positive B-Cell Marker  Negative  Positive T-Cell Marker  Negative   Positive Other:  Negative  Positive Other:  Negative   Positive Final Pathology Report. HenalDcescinomd  Histological Diagnosis: I Moole eale le. Oli ee tes Heieg Grade: Z Comments: Pathologist Dare Principal Investigator 5
+
+--- Page 3 ---
+CONSOLIDATED DIAGNOSTIC PAThOLOgy FORm* Microscopic Appearance: 1.Histological pattern: CELL DISTRIBUTION Diffuse + STRUCTURAL PATTERN Mosaic Streaming + Necrosis x  Storiform Lymphocytic Infiltration  Fibrosis X # Palisading Vascular Invasion Clusterized X Cystic Degeneration Alveolar Formation Bkeding Indian File K  Myxoid Change ZPsammoma/Calcification 2. Cellular features: Squa mous + Adenomatous + Sarcomatous Squamoid Cell Giandular cell +I . Lymphomatous Round Cell Spindle Cel! Lage Cell Cell Suratification Fibroblast Small Cell Keratin Secretion 4. Osteoblast Desmosome RS CeIVRS Like Intracyt. Vacuole Lipoblast Pear! Inflam. Celt Gland formation  Myoblast Plasma Cell Otherwise Specified: D so7 DU80% b>KZ 8oZ heekons 2.Cellular Differentiation: Well Moderately Poor Nuclear Atypia:. Nuckear Appearance Aniso Nuclcosis Hyperchromatism Nucleolar Prominent Multinucleated Giant Cel! Mitotic Activity Nuckear Grade Histological Diagnosis:Herert eel/ula Care? ong, le- Comments: Date ; PATHOLOGIST STAFF FOR RESEARCH USE ONLY). *(SNTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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diff --git a/output/text/059d7ae0-d705-4e5d-af86-0c86b8e74c15.txt b/output/text/059d7ae0-d705-4e5d-af86-0c86b8e74c15.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2fff178849503674ca7424356eeac8d136fa78e5
--- /dev/null
+++ b/output/text/059d7ae0-d705-4e5d-af86-0c86b8e74c15.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+JCs-0-3 Procedure Date:a Procedure Physician: Carcinomn mfiltnntiry cluctel, N05 8500[ Attending Physician/Copies To: Sife: 13/ssot, N1s c50.9 J20/11 UUID: 26F47A4F-B501-4C33-9D49-2039E98DBF26 Patient history: TCGA-BH-A1FN-01A-PR : DATE OF LMP: * Redacted DATE OF LAST DELIVERY: PRE-OP DIAGNOSIS: R BREAST CA POST-OP DIAGNOSIS: SAME OPERATIVE PROCEDURE: R SEGM MAST AND AXILL NODE DISS CLINICAL HISTORY: * MATERIAL SUEMITTED: A) RIGHT BREAST BIOPSY/MASS/SEGMENTAL MASTECTOMY, PROCUREMENT BY SURGICAL PROCEDURE routine sutures B) RIGHT AXILLA, PROCUREMENT BY SURGICAL PROCEDURE INTRAOPERATIVE CONSULTATION: FRozeN secrron: Right breast tissue; 8.0 by 8.0 by 3.0 cm. Tumor is 2.6 by 2.6 by 2.5 cm. Margins grossly free.: Frozen Section Diagnosis: Infiltrating ductal carcinoma. ER/pr taken.. FINAL DIAGNOSIS: FINAL DIAGNOSIS: RIGHT BREAST MASS: AEAPS INYILTRATING DUCTAL CARCINOMA, NOT OTHERWISE SPECIFIED, HISTOLOGIC GRADE 3, NUCLEAR CRADE POOR, VASCULAR INVASION PRESENT, TUMOR NECROSIS REPRESENTIIG 30t OF TUMOR MASS: TUMOR GREATEST DIAIGTER 2.6 BX 1.6 BY 2.5 CM INKED MARGINS FREE OF TUMOR B) RIGHT AXILLARY NODES: TWENTY-NINE (29) LYMPH NODES, FREE OF TUMOR
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diff --git a/output/text/05b8d094-1d0f-473c-8bfa-cb3c22232831.txt b/output/text/05b8d094-1d0f-473c-8bfa-cb3c22232831.txt
new file mode 100644
index 0000000000000000000000000000000000000000..32c7eb80e73e814f23e33752b9496ffa2dd910a9
--- /dev/null
+++ b/output/text/05b8d094-1d0f-473c-8bfa-cb3c22232831.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+/cs-0.3 Cucnoma Mf1t^atmg duct, N0s 85o0/3 Site. srst, Nos c5o.9 4/7/ M Procurement Date Laterality:Left, lower inner quadrant Path RepOrt:BREAST TISSUE CHECKLIST Specimen type: Radical mastectomy Specimen size: Not specified Tumor site: Lower inner quadrant Tumor size: 2.7 x 0 x 3.2 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinoma Histologic grade: Moderately differentiated Tumor extent: Skin Lymph nodes: 6/10 positive for metastasis (Axillary 6/10) Extracapsular invasion of the lymph nodes: Not specified Margins: Uninvolved. Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined TCGA-E9-A226-01A-PR Redacted Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None
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diff --git a/output/text/05cc4095-1560-4b42-955b-f09094e57c3f.txt b/output/text/05cc4095-1560-4b42-955b-f09094e57c3f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..07441964175a084d03041fb82f3f964f15660673
--- /dev/null
+++ b/output/text/05cc4095-1560-4b42-955b-f09094e57c3f.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SURGICAL PATHOLOGY REPORT DIAGNOSIS DIAGNOSIS: A.Soft tissue,peritumor fatexcision: Benign adipose tissue with no neoplastic process identified. B.Kidneyposterior margin #1biopsy No tumor identified. Permanent sections confirm the frozen section diagnosis. C.Kidney,right partial nephrectomy Tumor Characteristics: .Histologic type: Renal cell carcinoma, papillary subtype. 2.Tumor site:Right kidney 3.Tumor focality:Unifocal. Tumor size:4.0 cm in greatest dimension. 5. Macroscopic extent of tumor:Tumor limited to kidney. 6.Microscopic extent of tumor:Foci of transgression of renal capsule. 7 Nuclear grade: Fuhrman grade2/4. 8.Lymphovascular space invasion: Not identified. 9. Sarcomatoid features:Not identified. Surgical Margin Status: 1 .Tumor not identified at surgical margin. 2.Tumor present at inked capsular surface. Lymph Node Status: 1.No lymph nodes submitted for evaluation. Other: 1.pTNM stage:T3a. COMMENTS: The renal neoplasm predominantly has a papillary architecture with areas of interstitial macrophages.Foci of clear cell change are present. The lesion is felt to have an overall appearance of a papillary renal cell carcinoma. This case was reviewed by who agrees with the diagnosis ASSSSSCLINICAL INFORMATION CLINICAL HISTORY: Preoperative DiagnosisRight renal mass Postoperative Diagnosis: Symptoms/Radiologic Findings: SPECIMENS: A.Peritumor fat B.Posterior margin #1 with frozen section C.Right renal tumor GROSS DESCRIPTION: The specimen is received in three containers labeled with the patient's name, Container A is additionally labeled peri tumor fat and contains two yellow-tan fibrofatty soft tissues,1.1 x 0.7 x 0.4 cm and 2.0 x 1.0 x 0.4.cm.No nodules or lesions are identified. The specimen is entirely submitted in cassette A labeled Container B is additionally labeled Posterior margin #1" and contains two pink-tan soft tissues, each measuring 03 cm in areatest dimension Thes
+
+--- Page 2 ---
+sues are entrely submitted for frozen section with the residual wrapped in tissue paper and entirely resubmitted for permanent section in cassette B labeled Container C is additionally labeled "right renal tumor and contains a 3.0 x 2.5 x 2.5 cm,partly fragmented partial nephrectomy specimen. The deep margin is remarkable for pink-tan normal appearing renal parenchyma which is grossly uninvolved with tumor. The remainder of the specimen is greatest dimension. This tumorabuts the inked capsule and to within 0.7 cm of the parenchymal margin. No additional lesions are identified. The specimen is entirely submitted in cassettes C1-7 labeled designated as follows: C1-4 mass to inked parenchymal margin and capsule, emendicular 5-7 tumor. Additionally,a yellow,green ana biue cassette are submitted for genomics researcheach labele INTRA-OPERATIVE CONSULTATION: FROZEN SECTION DIAGNOSIS PART B: No tumor identified on frozen section per
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diff --git a/output/text/05ef87e2-160a-4653-bab4-c0224232401b.txt b/output/text/05ef87e2-160a-4653-bab4-c0224232401b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0cd1c2be05881ab3b94f92c87d327608a90a594e
--- /dev/null
+++ b/output/text/05ef87e2-160a-4653-bab4-c0224232401b.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+tcD-o-3 UUID: 08D3F046-01AD-40B2-A4EC-1121366614CA Redacted or^cunomo; Crd^eual Cortcos837/3 Site: Adrenal Gland cortek Procedure: adrenalectomy, left renal vein and LN C*74.o Gross description: 17 x 10 x 8cm JO x/6/13 Diagnosis: adrenocortical carcinoma, Kl67 10% Reference Pathology:. Diagnosis: adrenocortical carcinoma Weiss score: 5 Hough score: 3.13 Van Slooten score: 18
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diff --git a/output/text/060be346-093a-4d38-9bc1-70854b422fb4.txt b/output/text/060be346-093a-4d38-9bc1-70854b422fb4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..cced8a597da4c765395d3a819cf2c412aee02f83
--- /dev/null
+++ b/output/text/060be346-093a-4d38-9bc1-70854b422fb4.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+1cd-0 -3 12. /8f,0 8500/3 Lu Path CqcF Srte: Srt,nos c50.9 TSS SPECIMENS: UUID:8FE8DA40-59FF-4E76-A981-F46BA87C3E4A A. SENTINEL LYMPH NODE #1 LEFT AXILLA TCGA-E2-A1ST-01A-PR  Redacted B. SENTINEL LYMPH NODE #2 LEFT AXILLA C. LEFT BREAST D. LEFT BREAST SKIN E. RIGHT BREAST TISSUE SPECIMEN(S): A. SENTINEL LYMPH NODE #1 LEFT AXILLA B. SENTINEL LYMPH NODE #2 LEFT AXILLA C. LEft BREAST D. LEFT BREAST SKIN E. RIGHT BREAST TISSUE INTRAOPERATIVE CONSULTATION DIAGNOSIS: TPA/TPB-SLN #1, #2: Negative for carcinoma Diagnosis called by Dr. to Dr. at (A, B). GROSS DESCRIPTION: A. SENTINEL LYMPH NODE #1 LEFT AXILLA Received fresh labeled with the patient's identification and "sentinel LN #1" is a fragment of yellow fibroadipose tissue, 5 x 3 x 1 cm containing a lymph node measuring 2 x 1 x 0.9 cm. The lymph node is sectioned and a touch prep performed; lymph node submitted entirely in A1. B. SENTINEL LYMPH NODE #2 LEFT AXILLA Received fresh labeled with the patient's identification and "sentinel LN #2" is a fragment of yellow fibroadipose tissue measuring 2.5 x 1.5 x 1 cm containing a 1.5 x 1 x 0.9 cm lymph node. It is sectioned, a touch prep is performed, and lymph node is submitted entirely in B1. C. LEFT BREAST Received fresh labeled with the patient's identification and "left breast" is an oriented 1408 g, 28 x 20 x 4 cm mastectomy with 17 x 7 cm skin ellipse and a 0.9 cm everted nipple. Ink code: Anterior/superior-blue, anterior/inferior-orange, posterior-black. Specimen is serially sectioned into 12 slices from lateral to medial with nipple in slice 7 revealing a 7.2 x 5.8 x 3.2 cm ill-defined infiltrating mass extending from the 12 to 3 o'clock positions in the upper outer quadrant in slices 3-7 that is closest to the anterior margin at 1.2 cm. In the axillary region is a possible lymph node, 2.3 x 1.5 x 0.6 cm. Representatively submitted: C1: slice 2, u0Q lateral to lesion C2-C3: slice 3, UOQ lesion (bisected) C4: slice 4, UOQ superior portion of lesion. C5-C6: slice 4, uOQ lesion (bisected) C7: slice 4, LOQ inferior lesion C8: slice 5, UOQ superior to lesion C9: slice 5. posterior margin (grossly closest deep margin) C10: slice 6, mid section including lesion C11: slice 7, mid section C12: slice 8, medial to lesion C13: slice 9, UIQ C14: slice 11, LiQ C15: slice 2, LOQ C16: slice 1, UOQ C17: possible lymph node C18-C19: skin and nipple (bisected perpendicular sections) D. LEFT BREAST SKIN  Received in formalin labeled with the patient's identification and "left breast skin" is an unoriented tan pink skin excision 32 x 1cm excised to a depth ranging from 0.4cm to 1.8cm. The skin surface is grossly unremarkable. Representatively submitted in D1-D2. E. RIGHT BREAST TISSUE  Received in formalin abeled with the patient's identification and "right breast tissue" is a 236g, 27 x 12 x 5.4cm aggregate of fibrofatty tissue with attached unremarkable tan pink skin 10.5 x 4.3cm. The specimen is serially  sectioned to reveal unremarkable breast parenchyma. Representatively submitted in B1-B2. DIAGNOSIS: A. SEnTineL Lymph NOde 1, LEft AXiLLA, BiOpSy: - ONE LYMPH NODE, NO TUMOR SEEN (0/1).
+
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+B. SEnTineL Lymph NODe 2, Left AXILLA, BIOpSy: - ONE LYMPH NODE, NO TUMOR SEEN (0/1). C. BREAST, LEFI/SIMPLE MASTECTOMY: - INVASIVE DUCTAL CARCINOMA, SBR GRADE 2, WITH MUCINOUS FEATURES - INVASIVE CARCINOMA MEASURES AT LEAST 3 CM. - MARGINS, FREE OF TUMOR. - DUCTAL CARCINOMA IN SITU (DCIS), MICROPAPILLARY, PAPILLARY, CRIBRIFORM, AND SOLID TYPES, NUCLEAR GRADE 2, WITH NECROSIS. - SKIN, NIPPLE, AND SKELETAL MUSCLE, NO TUMOR SEEN.  NOTE: The tumor invoives the upper outer quadrant and consists of multiple foci of invasive carcinoma admixed with DCIS. On a single slide, the largest.focus of invasive carcinoma measures at least 3 cm. Invasive carcinoma spans an area ~ 7 cm. D. SKIN, LEFT BREAST, EXCISION: - SKIN, NO TUMOR SEEN. E. BREAST, RIGHT, EXCISION:  APOCRINE METAPLASIA AND STROMAL FIBROSIS. - BENIGN SKIN. SYNOPTIC REPORT - BREASTE Specimen Type: Mastectomy Needle Localization: No Laterality: Left Invasive Tumor: Present Multifocality: Yes WHO CLASSIFICATION Invasive ductal carcinoma, NOs 8500/3 Tumor size: 3cm Tumor Site: Upper outer quadrant Margins: Negative Tubular Score: 3 Nuclear Grade: 2 Mitotic Score: 2 Modified Scarff Bloom Richardson Grade: Absent 2 Necrosis: Vascular/Lymphatic Invasion: None identified Lobular neoplasia: None Lymph nodes: Sentinel lymph node. Lymph node status: Negative 0/2 DCIS present  Margins uninvolved by DCIS DCIS Quantity:Estimate 35% DCIS Type: Solid Cribriform Micropapillary Papillary DCIs Location:Associated with invasive tumor. Nuclear grade: Intermediate Necrosis: Present ER/PR/HER2 Results ER: Positive PR: Positive HER2: Negative by FISH Performed on Case: Pathological staging (pTN): pT 2 N O  Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition CLINICAL HISTORY: Multicentric cancer left breast; two areas were core biopsy showed invasive cancer ADDENDUM: ONCOTYPE DX BREAST CANCER ASSAY
+
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+RESULTS: Recurrence Score: 21 CLINICAL EXPERIENCE: Patients with a recurrence score of:  21 in the clinical validation study had an average rate of Distant Recurrence at 10 years of 14% ER Score: 12.1 Positive PR Score: 5.5 Positive Her2 Score: 10.3 Negative Interpretation: ERNegative <6.5Positive >= 6.5 PRNegative <5.5 Positive >= 5.5 Her2 Negative <10.7 Positive >=11.5 Equivocal = 10.7 - 11.4 See separate report for further information. Test performed at: Final Review: Pathologist, ( Final: Pathologist, Addendum: Pathouyist, Addendum Final: Pathologis
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diff --git a/output/text/06170c34-d46a-42fd-b7cc-7eb984e5dcb0.txt b/output/text/06170c34-d46a-42fd-b7cc-7eb984e5dcb0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f8b6d6153e2f410b36f02154f7554d99e3a40e0e
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+UUID: 4311425D-5160-4EED-BE1F-8532320AAF39 Redacted Lymph node of 3,6x2,5x1,6 cm. The surface is smooth and whitish.. LEFT INGUINAL LYMPH NODE (BIOPSY)  DIFFUSE LARGE B-CELL LIMPHOMA WITH FOCAL PLASMOCELLULAR DIFFERENCIATION. The lymph node shows a practically complete substitution of the normal. tissue by a diffuse lymphoid proliferation of large cells, showing occasionally plasmocellular differentiation. The immunohistochemical study shows that the neoplastic cells are positive for CD20, CD79a, CD43 BCL2, BCL6 and MUM1 and negative for CD3, CD5, CD10, CD23, CD21 and p53. The cells show kappa light chain restriction The Ki67proliferation index is approximately around 60%.. No rearrangement of the BCL2 gene by PCR (MBR) MCR) has been observed 10D c3 JscJ3 Sute.: Lyny.h mtde, siyural 0 C77  r () 3/31/14 w 12/313
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diff --git a/output/text/064f5bba-44e9-4ea0-a829-87c31dd2fdd1.txt b/output/text/064f5bba-44e9-4ea0-a829-87c31dd2fdd1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0352574d3dc123dcc3211104964f8c28265a1af0
--- /dev/null
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+1cs-0-3 Site; bruest,Nos C50.9 SUrgiCAL RepORt Name  Pathology Number Sex: F Date Collected: DOB Date Received: Location: M.R. Number: Doctor: Account Number: ** this is a corrected report ** UUID:9BAD4BD4-A54B-4115-A00E-6AA88F344FE1 TCGA-A2-A0YC-01A-PR Redacted PrE-OpErAtive DIAgNOSIS Right breast Cancer post-OPeRAtIve DiAgnOSIS RighT BreAst CANCER PROCEDURE Excision BiOpsy right Breast LumpectOmy with sent!nel Lymph noDe biOpsy (f.S.) TISSUES A. LYMPH NODE (S) - RIGHT SENTiNEL LYmPH NODE #1 **FS** B. LYMPH NODE (S) - RIGHT SENTINEL LYMPH NODE #2 **FS** C. LYMPH NODE (S) - ADDITIONAL NODE NON SENTINEL **FS** D. BREAST EXCISION,NEEDLE LOC,SIMPLE,MARGINS,ETC. - RIGHT BREAST LUMPECTOMY WRI TiSSUE ADDENDUM Immunostain for Cytokeratin was performed on spec!mens "A", "B", "C" and is negative for mstastatic adenocarcinoma. Rsvlewed and electronkalty signed out by: , Pathologlst FS DIAGNOSIS A. Right Sentinel Lymph nOde #1, F.s. - Negative Lymph NODe (2 bLOCKS). B. RIght Sentinel Lymph nOde #2, f.s. - NegATive Lymph nODe. c. NOn-SenTinel nOde, F.S. -  Negative lymph node. D. RIGhT BREAST (GROSS MARGINS) - MARGINS ARE FREE (GROSS). (Reported to Surgeon 1 Patlent Na F SURGICAL REPORT
+
+--- Page 2 ---
+Patlent Name  Pathology Number: Dlagnosed by: FINAL DIAGNOSIS A. Right SenTinel Lymph nODe #1 - One positive lymph nOde (1/1, micrOscopic metastaTic Ductal CARCINOMA, 1 MM IN MAXIMAL DIMENSION. PLEASE SEE COMMENT). B. Right SenTIneL Lymph NOde #2 - ONe NEgative lymph nODe (0/1). c. NOn-sentinel Lymph noDe - ONe NEGATiVE LyMPh NODE (0/1). D. Right sreast Lumpectomy - MODERATeLy DiFFERenTIaTeD iNFILTrATing DUctAL CARCinoMA SCARFF-BLOOM-RICHARDSON GRADE II/Il. THe TUmOR MEASURES 2.5 Cm. in MAXImUm DImENSION. All Surgical mArgins Are free of The Lesion. the clOsest Surgical MArgiNS ARe ThE DEEP (pOSteRIOR) SUrgICAl mArgin WhICh IS 1 Mm. frOm TUmOR (SLiDe 6) AND The infERIOR MARgin, WHICh IS 4mM FrOm THe iNfERiOR  MArgin (sl iDe 4) . TumOr StAge: STAgE IiB, T2, N1mIc, MX (GRADE 2). Dlagnosed by: Revlewed and slectonicaln slaned out by: COMMENT Specimen *A" shows microscopic metastatic carcinoma which is only present in the permanent section and not in the frozen section. This case is discussed with on i by COMMENT2 This case Is amended at the request of. ' to correct the tumor stage from T2, N1, MX to T2, N1mIc, MX GROSS DESCRIPTION The specimen is received in four separate containers labeied. esignated A, B, C, D. A. The container Is received fresh unfixed labeled "right sentinel lymph node #1 for frozen section". The specimen consists of an ovoid nodule of tan-gray firm rubbery tissue which is 1.5 x 1 x 0.4 cm. and has attached fatty material. A single node is bisected and entirely submitted as two frozen sections by Dr. The entire specimen including frozen sectlons are submitted. In three blocks. B. The container is received fresh unfixed labeled *right sentinel lymph node #2 for frozen section" The specimen consists of an ovold nodule of firm tan-gray sot rubbery tlssue and attached fat Patlent Name: Pathology Number:e SURGICAL REPORT Page 2 of 3
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+ Pathology Number Patlent Name and measures 1 x 0.3 x 0.3 cm. The node is bisected and entirely submitted as a frozen section by Dr. The entire specimen including frozen section is submitted In two blocks.. C. The container is received fresh unfixed labeled *additlonal node non-sentinel for frozen section". The specimen consists of an ovoid nodule of plnk-tan firm rubbery tissue with a scant amount of attached fat 0.6 x 0.4 x 0.3 crn. in greatest dimension. The entire specimen Is submitted as a frozen section by Dr.  The entlre specimen is subnitted in one biock. D The container is received fresh unfixed labeled "right breast lump" and consists of a 41 gm. ovoid mass of apparent fatty tissue with an attached skin ellipse 5 5 x 4.5 x 3.5 cm. in greatest overal! dimension. The attached skin ellipse is 4 x 1 cm. in greatest overall dimension. Gross margins. are observed and appear free by Dr There is a long suture indicating lateral margin inked wlth purple dye, medial is inked red. There is a single short suture indicating superior margin inked with orange dye, inferior is inked black. The skin is designated as anterior. posterior is inked yellow. Sectioning reveals a firm tan-gray striated mass which is 2 5 x 2 cn. in greatest overali dimension and grossly appears to be 0.4 cm. away from the inferior marg.n, 0 8 cm. away from the superior margin, 03 cm. away from the posterior. 0.8 cm. away from the medial margin and 1 cm. away from the Inferior. The specimen is submitted in eleven blocks.. Key Note Block Summary: 1---lateral, 2-- medial, 3--- superior, 4--- inferlor, 5---anterlor. 6--- posterior, 7 through 10---turnor, 11---skin. MICROSCOPIC EXAM MICrOSCOpIC EXAMINATION COnDUCTED by PATHOLOgISt CONFIRmS FinAL DIAGNOSIS. SPECIAL STAINS PERFORMED: Cytokeratin (AE1/AE3) (specimens A, 8, C) (LQ) Patlent Name: .  Pathology Number: SURGICAL REPORT Page 3 of 3
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diff --git a/output/text/0686e591-5f01-479c-9235-0ad12e635347.txt b/output/text/0686e591-5f01-479c-9235-0ad12e635347.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b7a299e404e222bb4babb9d007982ca147da61f9
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+Page 1 of 6 UUID: FACDA2AA- EE41-4EF5-8599-E72249E4B715 tCgA-XF-A9Sy-01A-PR Redacted mallented DIAGNOSIS: 1Cw-O -3 CYSTECTOMY WITH URINARY DIVERSION (T-POUCH) : arcnomre, uestrlalNOS 8120/3 RIGHT DISTAL URETER (A): INTRAOPERATIVE FROZEN SECTION DIAGNOSIS: NO HIGH GRADE ATYPIA OR TUMOR IDENTIFIED FINAL DIAGNOSIS: BENIGN URETER  NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED C67.4 LEFT DISTAL URETER (B) : YN 3l2e1!4 INTRAOPERATIVE FROZEN SECTION DIAGNOSIS:  NO HIGH GRADE ATYPIA OR TUMOR IDENTIFIED FINAL DIAGNOSIS: BENIGN URETER NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED BLADDER NECK MARGIN (C) : INTRAOPERATIVE FROZEN SECTION DIAGNOSIS: BENIGN FINAL DIAGNOSIS: BENIGN URETHRAL AND PERIURETHRAL TISSUE NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED BLADDER/UTERUS, FALLOPIAN TUBES, OVARIES, PERIVESICAL LYMPH NODES (D) : BLADDER: POORLY DIFFERENTIATED INVASIVE UROTHELIAL CARCINOMA (4.9 X 4.7 X 1.5 CM) 07 cbar cell WITH FOCAL CLEAR CELL FEATURES, GRADE 4/4, PENETRATING THROUGH FULL THICKNESS OF BLADDER WALL INTO PERIVESICAL SOFT TISSUE pvv T3s EXTENSIVE ASSOCIATED ULCERATION PRESENT FOCUS OF LYMPHOVASCULAR SPACE INVASION IDENTIFIED NO UROTHELIAL CARCINOMA IN SITU (FLAT LESION) SEEN IN RANDOM MUCOSA FOLLICULAR CYSTITIS WITH ASSOCIATED REACTIVE UROTHELIAL CHANGES RESECTION MARGINS, FREE OF DYSPLASIA AND MALIGNANCY UTERUS : ENDOMETRIUM, FOCUS OF NONINVASIVE WELL DIFFERENTIATED ENDOMETRIAL ADENOCARCINOMA, FIGO GRADE 1/3, ARISING IN BACKGROUND OF POLYP AND ENDOMETRIUM EXHIBITING COMPLEX HYPERPLASIA WITH ATYPIA NO CERVICAL,  MYOMETRIAL OR LYMPHOVASCULAR INVOLVEMENT IDENTIFIED MYOMETRIUM, NO SIGNIFICANT HISTOPATHOLOGIC CHANGE SEROSA, ENDOSALPINGIOSIS CERVIX,  BENIGN SQUAMOUS AND ENDOCERVICAL MUCOSA WITH NO DYSPLASIA OR MALIGNANCY IDENTIFIED RESECTION MARGINS, FREE OF MALIGNANCY RIGHT AND LEFT FALLOPIAN TUBES: LEFT, BENIGN SIMPLE PARATUBAL CYST RIGHT, NO SIGNIFICANT HISTOPATHOLOGIC CHANGE  NO ATYPIA OR MALIGNANCY IDENTIFIED RIGHT AND LEFT OVARIES: BILATERAL MULTIPLE SIMPLE SURFACE INCLUSION CYSTS  NO MALIGNANCY IDENTIFIED PERIVESICAL LYMPH NODES: METASTATIC UROTHELIAL CARCINOMA IDENTIFIED IN ONE OF THREE LYMPH NODES EXAMINED (0/0 RIGHT, 1/3 LEFT, 1/3 TOTAL), WITH METASTASIS 0.9 CM GREATEST
+
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+Page 2 of 6 Collecfed RIGHT PARACAVAL LYMPH NODES (E) :  NO MALIGNANCY IDENTIFIED IN SIX LYMPH NODES EXAMINED (0/6) RIGHT COMMON ILIAC LYMPH NODES (F): NO MALIGNANCY IDENTIFIED IN EIGHT LYMPH NODES EXAMINED (O/8) PRESACRAL LYMPH NODES (G): NO MALIGNANCY IDENTIFIED IN 16 LYMPH NODES EXAMINED (0/16) ENDOSALPINGIOSIS RIGHT LYMPH NODE OF CLOQUET (H) : NO MALIGNANCY IDENTIFIED IN TWO LYMPH NODES EXAMINED (O/2) RIGHT EXTERNAL ILIAC LYMPH NODES (I) :  NO MALIGNANCY IDENTIFIED IN SIX LYMPH NODES EXAMINED (O/6) RIGHT OBTURATOR / HYPOGASTRIC LYMPH NODES (J) : NO MALIGNANCY IDENTIFIED IN SEVEN LYMPH NODES EXAMINED (O/7) LEFT PARA AORTIC LYMPH NODES (K):  NO MALIGNANCY IDENTIFIED IN EIGHT LYMPH NODES EXAMINED (0/8) LEFT COMMON ILIAC LYMPH NODES (L) : NO MALIGNANCY IDENTIFIED IN EIGHT LYMPH NODES EXAMINED (O/8) LEFT LYMPH NODE OF CLOQUET (M):  NO MALIGNANCY IDENTIFIED IN ONE LYMPH NODE EXAMINED (O/1) LEFT EXTERNAL ILIAC LYMPH NODES (N) : NO MALIGNANCY IDENTIFIED IN SEVEN LYMPH NODES EXAMINED (O/7) LEFT OBTURATOR / HYPOGASTRIC LYMPH NODES (O) : METASTATIC UROTHELIAL CARCINOMA IDENTIFIED IN ONE OF 14 LYMPH NODES EXAMINED (1/14), WITH METASTASIS 0.4 CM GREATEST DIMENSION RIGHT PROXIMAL URETER (P) :) BENIGN URETER  NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED LEFT PROXIMAL URETER (Q): BENIGN URETER  NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED LYMPH NODE SUMMARY: METASTATIC CARCINOMA IDENTIFIED IN TWO OF 86 LYMPH NODES EXAMINED (2/86) PATHOLOGIC TNM STAGE: BLADDER:S pT3bN2MX COMMENT: Representative sections of invasive urothelial carcinoma are submitted for p53
+
+--- Page 3 ---
+Page 3 of 6 Collected SPECIMEN SOURCE: A: "RT distal ureter". B "Lt. distal ureter" C: "Bladder neck margin" D: "Bladder/uterus, tubes, ovaries, peri vesicles lymph node" (sic) E: "Rt. para caval lymph nodes" F: "Rt. common iliac lymph nodes" G: npre sacral lymph nodes" H: "Right lymph node of cloquet" I : "Right external iliac lymph node" J : "Rt. obturator/hypogastric lymph nodes" "Lt. para aortic lymph nodes" K L: "Lt. common iliac iymph nodes" M: "Lt. lymph node of cloquet" N: "Lt. ext. iliac lymph nodes" 0:  "Lt. obturator/hypogastric lymph nodes". P: "Rt. proximal ureter" Q: "Lt. proximal ureter" CLINICAL INFORMATION: Pre-Op Dx: Bladder cancer Post-Op Dx: Same as pre-op GROSS EXAMINATION: A: The specimen is received fresh from the O.R. and labelled "RT distal ureter". It consists of a segment of ureter measuring 0.4 cm in length by 0.4 cm in diameter with attached fat.  Entirely submitted for frozen section in cassette AFs. B: The specimen is received fresh from the O.R. and labeled "Lt. distal ureter".. It consists of a segment of ureter measuring 0.4 cm in length by 0.3 cm in diameter with attached fat. Entirely submitted for frozen section in cassette sFs. C: The specimen is received fresh from the O.R. and labelled "Bladder neck. margin"'.  It consists of a ring-shaped, tan-pink soft tissue segment measuring 2.1. x 1.5 x 0.5 cm.  Entirely submitted in one cassette for frozen section in cassette Cfs. D: The specimen is received fresh from the O.R. and labelled "Bladder/uterus,. tubes, ovaries, peri vesicles lymph node" (sic). It consists of an anterior. exenteration specimen measuring 13.5 x 12 x 5 cm overall. It includes bladder with attached bilateral ureters, cervix, uterus, bilateral fallopian tubes, bilateral ovaries and peritoneum. The peritoneum measures 7 x 12 by less than 0.1 cm. It is tan, smooth, glistening and unremarkable. The surgical margin is inked black. The. bladder itself measures 6.5 x 6.5 x 5 cm.  Opening the bladder anteriorly reveals an ulcerated mass located in the anterior wall and extending to the left lateral wall. It measures 4.9 x 4.7 cm in area by 1.5 cm in depth. ~It is 0.4 cm from the left ureterovesical junction and 2 cm from right ureterovesical junction and. approximately 0.7 cm from the bladder neck margin. Grossly, it involves the full thickness of the bladder wall extendning into perivesical soft tissue. It comes within approximately 0.3 cm of the anterior inked radial margin and o.4 cm of the. inked left lateral radial margin. The remainder of the mucosa is flat with patchy tan-pink areas.  The involved bladder wall measures 1.8 cm in thickness. The uninvolved wall measures 0.7 cm in thickness. The attached right and left ureters measure 8 cm in length by 0.7 cm in circumference and 6.5 cm in length by 0.7 cm in circumference, respectively.  Both have mucosa that is tan-pink, smooth, glistening and unremarkable without tumor involvement. The uterus with attached cervix measures 6.5 x 4.5 x 3.4 cm. The ectocervix measures 3.5 cm across. The
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+Page 4 of 6 Golecfedr exocervical os is siit-like measuring 1.4 cm across.  Bilvalving the uterus reveals an endocervical canal measuring 2.2 cm in length and 0.9 cm in circumference. It contains tan-pink, smooth and unremarkable mucosa. The endometrial cavity measures 3.2  0.7 cm and contains strips of endometrium measuring 0.1 cm in average thickness. Also noted is a pedunculated endometrial polyp located on the left wall and measuring 1.8 x 0.5 x 0.3 cm..  Otherwise the endometrium is unremarkable.  The myometrium measures 1.7 cm in average thickness and is unremarkable.  The right faliopian tube measures 7 cm in length by 0.4 to 0.8 cm in diameter, and is unremarkable.  The left fallopian tube measures 7 cm in. length by 0.4 to 0.8 cm in diameter. There is a thin walled cyst attached to the fimbria that measures 1 cm in diameter.  The right ovary measures 2.4 x 1 x 1.1 cm.. On the surface are two thin walled cysts measuring 0.3 and 0.4 cm in diameter. The sectioned ovary contains another 1.1 cm in diameter unilocular clear fluid filled cyst.  Otherwise the ovary is unremarkable. The left ovary measures 2.4 x 1 x 0.8 cm with a finely nodular surface..  On cross section, it contains a uniloculated. fluid filled cyst measuring 0.7 cm in diameter. This ovary too is otherwise unremarkable.  There is a 2 cm in dimension firm nodule identified in the left perivesical soft tissue.  Representative sections are submitted in a total of 24 cassettes. E: The specimen is received in formalin and labelled "Rt. para caval lymph nodes". It consists of a 3.3 x 1.6 x 0.6 cm segment of fibrofatty tissue containing lymph nodes measuring 2.6 x 0.6 x 0.5 cm. The entire specimen is submitted in one cassette. F: The specimen is received in formalin and labelled aRt. common iliac lymph nodes". It consists of multiple segments of yellow fatty tissue measuring 3.7 x 3.7 x 1 cm in aggregate. It contains multiple lymph nodes ranging from o.8 cm to 2.8 cm in greatest dimension. The entire tissue is submitted in two cassettes. G: The specimen is received in formalin and labelled "pre sacral lymph nodes". It consists of a 5.7 x 3 x 0.8 cm segment of fibrofatty tissue entirely submitted in three cassettes. H: The specimen is received in formalin and labelled "Right lymph node of cloquet". It consists of a 3 x 2.2 x 0.6 cm segment of yellow iobulated fatty tissue. Entirely submitted in one cassette. I : The specimen is received in formalin and labelled "Right external iliac lymph. node". It consists of two segments of yellow lobulated fatty tissue measuring 4.7 x 4 x icm in aggregate. It contains multiple lymph nodes ranging from 0.6 to 1.1 cm in greatest dimension. Entirely submitted in two cassettes. The specimen is received in formalin and labelled "Rt. obturator/hypogastric J: lymph nodes". It consists of multiple segments of yellow fatty tissue containing. multiple lymph nodes ranging from 0.6 to 2.5 cm in greatest dimension. The entire. tissue is submitted in two cassettes. K: The specimen is received in formalin and labelled "Lt. para aortic lymph nodes". It consists of a 2.2 x 1.6 x 0.5 cm segment of fibrofatty tissue. Entirely submitted in one cassette. The specimen is received in formalin and labelled aLt. common iliac lymph nodes". It consists of a 4 x 2.6 x 0.7 cm segment of yellow fatty tissue containing multiple lymph nodes ranging from 0.4 cm to 1.2 cm in greatest dimension. Entirely submitted in two cassettes. M: The specimen is received in formalin and labelled "Lt. lymph node of cloquet". It consists of a 2.6 x 2.1 x 1.2 cm segment of yellow fatty tissue.  Entirely submitted in one cassette.
+
+--- Page 5 ---
+Page 5 of 6 nodes". It consists of a 7 x 1.1 x 0.9 cm segment of fibrofatty tissue containing. multiple lymph nodes which range from 0.7 to i cm in greatest dimension.. entire tissue is submitted in two cassettes. O: The specimen is received in formalin and labelled "Lt. obturator/hypogastric lymph nodes".  It consists of a 5.5 x 4 x 1.6 cm segment of fatty tissue containing multiple lymph nodes ranging from 0.3 cm to 2.3 cm in greatest dimension..  The entire tissue is submitted in four cassettes. P: The specimen is received in formalin and labelled "Rt. proximal ureter". It consists of a segment of ureter measuring 0.7 cm in length by 0.4 cm in diameter with attached adipose tissue. Bisected and entirely submitted in one cassette. Q The specimen is received in formalin and labelled *Lt. proximal ureter". It consists of a segment of ureter measuring o.s cm in length by o.4 cm in diameter,. with attached adipose tissue. Bisected and entirely submitted in one cassette. SECTIONS: AFS: frozen section, right distal ureter Bes: frozen section, left distal ureter. CFs: frozen section, bladder neck margin D1,2: anterior wall towards right D3: left anterior wall D4 : right lateral wall DS: D6: dome D7: posterior wall. D8: left ureterovesical junction D9-11: left lateral wall with ulcerated mass. D12: trigone and bladder neck D13: bladder neck margin to ulcerated mass, left side D14 : bladder neck margin to ulcerated mass, right side. D15: anterior cervix and uterine wall D16: posterior cervix and uterine wall with endometrial polyp D17: endometrial polyp D18: right fallopian tube, ovary and ureter D19: left fallopian tube, ovary and ureter D20: possible right perivesical lymph nodes D21-23: largest left perivesical nodule, quadrisected. D24 : possible left perivesical lymph nodes E: right paracaval lymph nodes - all embedded F1,2: right common iliac lymph nodes - all embedded. G1-3: presacral lymph nodes - all embedded H: right lymph node of Cloquet - all embedded 11: right external iliac lymph node; lymph node 12: remaining tissue J1: right obturator/hypogastric lymph nodes; largest lymph node J2 : remaining tissue and lymph node K: left para-aortic lymph nodes - all embedded L1,2: left common iliac iymph nodes - all embedded. M: left lymph node of cloquet N1 : left ext. iliac lymph nodes; lymph nodes N2 : remaining tissue 01,2: left obturator/hypogastric lymph nodes; multiple lymph nodes 03 : largest lymph node, bisected. 04 : remaining tissue P: right proximal ureter - all embedded Q: left proximal ureter - all embedded
+
+--- Page 6 ---
+Page 6of 6 eplleet INTRAOPERATIVE FROZEN CONSULTATION: AFS: Right distal ureter:.  no high-grade atypia or tumor identified BFS: Left distal ureter:  no high-grade atypia or tumor identified CFS: Bladder neck margin:  no high-grade atypia or tumor identified MICROSCOPIC EXAMINATION: A-C: See final microscopic-diagnosis. D: Sections of the bladder show a poorly differentiated invasive urothelial carcinoma (D1-3,9-11,13,14), grade 4/4, with focal clear features.  The carcinoma is associated with extensive ulceration and penetrates through the bladder wall into perivesical soft tissue (D1,2,10,11). A focus of lymphovascular space. and 1.2 cm of the bladder neck margin. All other radial margins and bilateral ureters margins are more widely free of malignancy. No trigone or ureterovesical junction involvement by dysplasia or malignancy is seen.  Metastatic urothelial. carcinoma is identified in one of three left perivesical lymph nodes examined D21-23. Sections of the uterus show a small focus of well differentiated endometrial adenocarcinoma, FIgo grade 1/3, arising in association with endometrium and a polyp containing complex endometrial hyperplasia with atypia (Dl5-17). No myometrial or cervical invasion is identified.' Ali surgical margins are free of malignancy. E-Q: See final microscopic-diagnosis.. h 3f3yi4
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diff --git a/output/text/06ab45a0-3341-485c-88f8-f5d3ca9851f1.txt b/output/text/06ab45a0-3341-485c-88f8-f5d3ca9851f1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..26641552724f2e984a7df77366b2198610f94f07
--- /dev/null
+++ b/output/text/06ab45a0-3341-485c-88f8-f5d3ca9851f1.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+ICD C. Xnfuitrnting duct Caunims Ncs lw f 5cv|3 S.r: brust, Nos 1220 c50.9 page 1 / 1 Department of Cancer Pathology copy No. Date: Examination: Histopathological examination. Examination No.:  Patier Pesel: Age: Gender: F  Material: Partial organ resection -- lesion from the left breast - lower outer quadrant. Unit in charge. Physician in charge: Material collected on: Material received on: Expected time of examination:. Clinical diagnosis: Cancer of the right breast, typical quadrant marking. Examination performed on: Macroscopic description:e Part of the breast sized 8.8 x 8.3 x 2.4 cm with a skin flap of 5.8 x 2.3 cm, marked typicaliy, with an X-ray image. Tumour cross section sized 1.7 x 1.5 x 2.3 cm. Margins: to the base 0.1 cm; do the skin surface 0.6 cm;. t9the sternum 2.2 cm, to the axilla 3.6 cm, to the shoulder 2.3 cm, lower 4.3 cm. /Microscopic description: Carcinoma ductale invasivum: NHG3 (3+3+3: 18 mitoses /10 HPF - diam. 0.55mm), pT2. Solitary DCIS focuses found beneath the tumour (solid type with medium atypia, no necrosis) placed 0.5 cm from the incision line.. Histopathological diagnosis: Resectio partalis mammae dextrae: Carcinoma ductale invasivum et ductale in situ (NHG3, pT2 ). fNVA61VE txCTAL CARciNOH4 AN 1N 3;rU NUTAL CARCINOHA u$THE RIstT BRERT Compliance validated by:  Examination performed on: Results of immunohistochemical examination:. Estrogen receptors in neoplastic cell nuclei not found.. Progesterone receptors in neoplastic cell nuclei not found.. HER2 protein stained with HercepTest. M by DAKO. Negative reaction in invasive cancerous cells ( Score = 0 ) Compliance validated by: UUID:380639A2-E89C-4495-8168-82120617129F TCGA-D8-A147-01A-PR Redacted
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diff --git a/output/text/06d647f0-0f3c-45fe-902d-57644c05d777.txt b/output/text/06d647f0-0f3c-45fe-902d-57644c05d777.txt
new file mode 100644
index 0000000000000000000000000000000000000000..936d2c438f67b6fd7013bbdebe0c6aec9239fa4d
--- /dev/null
+++ b/output/text/06d647f0-0f3c-45fe-902d-57644c05d777.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+ICs-0-3 Carcioms mfiHtrating cluct, Nos 8500/3 Sif : 6retst,N0s c50.9 4/7/1 Procurement Date: Laterality:Right, lower inner quadrant Path Report:BREAST TISSUE CHECKLIST Specimen type: Mastectomy Specimen size: Not specified Tumor site: Breast Tumor size: 2 x 1.5 x 2 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinoma Histologic grade: Moderately differentiated Tumor extent: Not specified Lymph nodes: Not specified Extracapsular invasion of the lymph nodes: Not specified Margins: Not specified Nottingham Histologic Score UUID:15FA41AE-3A0F-4112-828B-EE8687A6F158 TCGA-E9-A229-01A-PR Redacted Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None
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diff --git a/output/text/06f99d01-aba7-409a-879f-2c260762ae53.txt b/output/text/06f99d01-aba7-409a-879f-2c260762ae53.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6e60be08655222d8fe7b26032c1c82d5ee3364bd
--- /dev/null
+++ b/output/text/06f99d01-aba7-409a-879f-2c260762ae53.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+PoimaRy Stt at samtinc UUID: EA2ECCDC-A411-4926-A8E7-7375F329A687 TCGA-UZ-A9PS-01A-PR Redacted SURGICAL PATHOLOGy REPORT Patient Name Accession # j Med. Rec.#: Visit #: Service Date:1 DOB: Sex: Received: Location: Client: Soc. Sec. #: Physician(s): FInal Pathologic Diagnosis Left kidney, partial nephrectomy: Papillary renal cell carcinoma, Type 2, Furhman Grade 3, 13.2 cm; see comment.. IQD-043 Comment: Kidney Tumor Synoptic Comment ce0Q 8Q6D|3 -Histologic type: Papillary type. -Grade: Furhman grading for RCC: Grade 3.. -Maximum tumor diameter: 13.2 cm. -Site within kidney: Left lower pole. -Renal peivis: Not present. 3f|z -Ureter: Not present. -Renal sinus: Not present. -Hilar renal veins: Not present. -Intrarenal veins and iymphatics: Normal, no vascular invasion identified. -Adrenal gland: Not present. -Capsule/perirenal fat: Tumor does not penetrate capsule.. -Hilar lymph nodes (number positive/number of nodes): Not present. -Resection margins:  Negative. -Proximity to nearest margin: 1 mm to resection margin (Slide A1). -Stage: pT2NXMX. -Additional comments: This is a typical papillary renal cell carcinoma with a papillary growth pattern and stromal foam cells. Various cell types are present including chromophilic cells with eosinophilic cytoplasm, oxyphilic cells, and occasional clear cells. The relatively large tumor cell size, nuclear atypia, and pleomorphism indicate that this is a type 2 papilary cancer, which in some studies has been an adverse finding relative to type 1. The excision marginis free of tumor, although tumor approaches to within 1 mm of the inked edge of the specimen (slide A1).. Pw TSS, O?o cba cll diHfrn$stion. Specimen(s) Received A:Left renal mass (fresh) Page 1 of 2
+
+--- Page 2 ---
+Clinical History The patient is a year-old female with a 5 cm, solid mass in the lateral portion of the right kidney and a 9 cm mass in the lower portion of the left kidney. The patient now undergoes left partial nephrectomy. Gross Description The specimen is received fresh in one part, labeled with the patient's name, medical record number and *"left renal mass fresh," and consists of an unoriented partial nephrectomy specimen measuring 17 x 7.5 x 14.5 cm and weighing 468 gm with associated perinephric fat. There is a yellow-red, nodular, friable mass measuring 8.5 x 6.2 x 13.2 cm, completely filling and obliterating the inner portion of the kidney. The mass is completely circumscribed by the renal capsule and abuts its surface in multiple areas, but does not grossly extend through it. The mass abuts the resection margin (inked blue). The entire outer portion of the specimen is inked in black. The mass was opened prior to receipt in Pathology, and a piece of the tumor was sampled from the previously opened area for  In addition, an opposite end was opened to sample for normal renal tissue, but none was taken, as it was a completely obliterative tumor. Representative sections are submitted as follows: Cassettes A1-A2: Tumor with adjacent resection margin. Cassettes A3-A6: Tumor and renal capsule. Cassettes A7-A9: Tumor. Diagnosis based on gross and microscopic examinations. Final diagnosis made by attending pathologist following review of all pathology slldes. Pathology Resident sthologist Electronically signed out o Sunt Page 2 of 2
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diff --git a/output/text/070145e2-5374-4ffd-8d10-9e8a7d6141d6.txt b/output/text/070145e2-5374-4ffd-8d10-9e8a7d6141d6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c6005ac6c45108ae0e288bfabf3fde4d8e09c334
--- /dev/null
+++ b/output/text/070145e2-5374-4ffd-8d10-9e8a7d6141d6.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+FINAL DIAGNOSIS: Part 1: breast, Leet,12 O'clOck, Segmental. mastectomy - A.  InVasive Ductal CarcinomA.no Special type. B. NOTTINGHAm GRADE 2 (TUBAL fORMATION: 2, NUCLEAR PLEOMORPHISM: 2, MITOTIC ACTIVITY: 2; TOtal ScOre 6/9). C. THE iNVASiVE TUMOR MEASURES 1.5 CM IN LARGEST DImENSION. D. LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED. E. DUCTaL CARCInOmA iN SITU (DCIS), NUCLEAR GRADE 2, CRIBRIFORm TYPE WITH COMeDO NECROSIS. F. THE DCIS CONSTITUTES 20% OF THE TOTAL TUMOR VOLUME AND IS PRESENT ADMIXED WITH AND AWAY FROM THE iNVASIVE COMPONENT. G. MARGINS ARE NEGATIVE FOR CARCINOMA; INVASIVE CARCINOMA IS 0.5 CM FROM THE NEAREST (SUPERIOR) MARGIN. H. FIBROCYSTIC CHANGES, COLUMNAR CELL CHANGE, AND DUCTAL EPITHELIAL HyPERPLASIA. I. PREVIOUS BIOPSY SITE CHANGES. J. INVASIVE TUMOR CELLS ARE POSIT'/E FOR ESTROGEN AND PROGESTERONE RECEPTORS AND NEGATIVE FOR HER-2/NEU BY FISH K. PATHOLOGIC STAGE: pT1c, pN1a, pMX. Part 2: SEnTinel Lymph nOde #1, LEft AxilLA, biOpsy --  ONE LyMPH NODE, POSITIVE FOR METASTATIC CARCINOMA (1/3). B.  THe LArgeSt tumOr dEpOSIt iS 2.1 mm. C. EXTRACApSuLAR eXTenSIOn IS NOt PrESent. 1co-0-3 PArt 3: SenTIneL. Lymph nODE #2, LEft AXILLA, biOpSy  Cacnome, nji1trutry ouctl,nr5 85ot/3 -ONE LYMPH NODE. NEGATIVE FOR NEOPLASM I0/11. CASE SYNOPSIS: Sit: brenst No3 C50.9 313/u SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST LATERALITY: Left PROCEDURE: Segmental LOCATION: Upper outer quadrant Upper inner quadrant SIZE OF TUMOR:  Maximum dimension invasive component: 1.5 cm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: No TUMOR TYPE (invasive component): Ductal adenocarcinoma, NOS NOTTINGHAM SCORE: Nuclear grade: 2 UUID: C956B4B1-99E6-4823-886A-FA8FCD1E3E4D Tubule formation: 2 TCGA-BH-A0GZ-01A-PR Redacted Mitotic activity score: 2 Total Nottingham score: 6 Nottingham grade (1, 2, 3): 2 ANGIOLYMPHATIC INVASION: Yes DERMAL LYMPHATIC INVASION: Not applicable CALCIFICATION: Yes, malignant zones TUMOR TYPE, IN SITU: Cribriform DCIS admixed and outside of invasive carcinoma component SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No Distance of invasive tumor to closest margin: 5.0 mm SURG MARGINS INVOLVED BY IN SITU COMPONENT: No LYMPH NODES POSITIVE: 1 LYMPH NODES EXAMINED: METHOD(S) OF LYMPH NODE EXAMINATION: H/E stain NON-NEOPLASTIC BREAST TISsUE: FCD, Other: columnar cell change, ductal epithelial hyperplasia t stage, pathologic: pT1c N Stage, pathologic: pN1a m Stage, patholOgiC: pMX ESTROGEN RECEPTORS: positive PROGESTERONE RECEPTORS: positive HER2/NEU: 2+
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diff --git a/output/text/0723eb55-35d8-47d9-852d-14be79e17a77.txt b/output/text/0723eb55-35d8-47d9-852d-14be79e17a77.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2c05648d80cbec98d70d4bc6a2ac327dca8e154f
--- /dev/null
+++ b/output/text/0723eb55-35d8-47d9-852d-14be79e17a77.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+/cs-0-3 Carcinoma, mfiltnuting 1obulu,Nos 85xo/3 PH Sih: Brst, usq C50.4 CQCF9if: Aust,Nos C5o.9 Diagnosis: 1. Polymorphocellular undifferentiated breast, G il (maximum tumor diameter 2.8 cm) showing infiltrative growth, with marked chronic secondary inflammation, focal invasion of lymph vessels and spread to just below the skin.. The conventional histological findings are consistent with the polymorphocellular variant of invasive lobular breast carcinoma. The nodular tumor infiltration in the axillary tissue described under 6. is to be interpreted as a lymph node metastasis extending beyond the capsule into the surrounding soft tissue. This gives rise to the following summary tumor classification: G II, pT2pN1a(1/14)L1V0R0, negative for estrogen and progesterone receptors, positive for C-erb B-2 oncoprotein.. 306BE26-0358-4BE4-AEF6-AD42CC0DA020 Redacted
\ No newline at end of file
diff --git a/output/text/07530576-db9a-4ec8-976c-7ee3c9bf09be.txt b/output/text/07530576-db9a-4ec8-976c-7ee3c9bf09be.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0812d3ab55866a77649aa764e14122bcee7afb4b
--- /dev/null
+++ b/output/text/07530576-db9a-4ec8-976c-7ee3c9bf09be.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+TCGA-AK-3453 SURGICAL PATHOLOGY REPORT Clinical History/Diagnosis: Right Renal Mass Source of Specimen(s):. 1: Right kidney, portion of right ureter (with stent) and para caval nodes 2: right ureteral Stent Gross Description: Received in two parts. Source of Tissue: 1. Labeled #1, "right kidney, portion of right ureter. and paracaval nodes". Frozen Section Diagnosis: 1FS- ONCOCYTIC NEOPLASM PER Gross Description: Received fresh for frozen section evaluation labeled , right kidney, portion of right ureter and. paracaval nodes" is a 333 gram right nephrectomy having a minimal amount of attached perinephric fat. There is a 9.5 x 0.3 cm fragment of attached ureter having a lumen, 0.2 cm containing a stent. The kidney itself is distorted, 9.0 x 8.5 x 4.5 cm in greatest dimension. It is bisected to reveal a 8.5 x 6.0 x 5.0 cm mass protruding from the kidney having. yellow-tan to brown to red-purple focally hemorrhagic cut surfaces Representative sections of the mass are submitted for frozen section evaluation and the frozen section residue is submitted in one block. The remaining renal parenchyma is tan-brown having a well-defined. cortico-medullary junction. There are no palpable lymph nodes in the attached paracaval soft tissue. Representative sections are submitted in six blocks. Designation of Sections: 1FS- frozen section renal mass, 1A- ureter and vascular margins, 1B-1D- tumor, 1E- random kidney section, 1F- representative sections paracaval soft tissue. Summary of Sections: multiple. Note: Tissue is Submitted for Cytogenetic Studies and Gross Photographs are Taken. ************************************ ************************************ Source of Tissue: 2. Labeled # 2, "right ureteral stent". Gross Description: Received fresh in a container labeled ", right ureteral stent". It consists of a single lumen segment of light green stent measuring 54.2 x 0.4 cm. In the same container is a similar segment of stent measuring 2.9 cm. No blood or tissue present,
+
+--- Page 2 ---
+gross only.. ************************************************************************ Final Diagnosis:. 1. Right kidney, portion of right ureter (with stent), para caval lymph. nodes, resection:- Low grade renal cell carcinoma, 8.5 cm, suggestive of oncocytoma with transition to chromophobe tuinor.... - Extracapsular extension is not seen. - Lymphovascular invasion is not seen.. - The vascular and ureteral margins are negative, see note. 2. Right ureteral stent:. - Gross description only. Note: The tumor is focally positive for CD10, CK7 and AE1/AE3, and negative for. colloidal iron, vimentin, CD117, E-cadherin and RCC antigen. Positive and negative control slides are satisfactory Background biotin staining cannot be eliminated. These results support a diagnosis of oncocytoma, but appearance shows chromophobe features. These tests were developed and their performance characteristics determined by the immunohistochemistry laboratory at the These tests have not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement (CLIA) as qualified to perform high complexity clinical. testing. Procedures/Addenda FC Setup Charge Solid Tumor. Results-Comments CYTOGENETIC ANALYSIS REPORTS DIAGNOSIS: Right Renal Mass KARYOTYPE: Specimen inadequate for cytogenetic analysis. RESULTS: The renal tumor was minced and distributed among four flasks The specimen was contaminated with bacteria from inception and could not be cultured.
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diff --git a/output/text/0758c905-3ed2-4550-858a-69b1ab6d77d3.txt b/output/text/0758c905-3ed2-4550-858a-69b1ab6d77d3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b7cfbe4bfca229cb0b408a526a54cff3de59e7e3
--- /dev/null
+++ b/output/text/0758c905-3ed2-4550-858a-69b1ab6d77d3.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+TD63 denseaursrno) 1BS 8/4o|3 Esphagus,dlistob thvl C15.5 Khstisexspehaggol yurctor Ci6.D UUID:BE7411CD-1437-495B-86B0-9FE32E329C31 OS1/1?/14 TCGA-L5-A8NM-01A-PR Redacted ************** OpEr DATE: REO DOC: ACCESSION: PROCEDURE: VERIFIED BY: vear-old with chest pain and dysphagia. Clinical Diagnosis: Positive adeno of the CEgA, J-tube, esophagoscopy. PROCEDURE: 1. "Left cervical mass." A 2 x 1.5 x 0.8 cm tan-red soft tissue nodule with glistening lobular tan parenchyma. Bisected. 1A. Frozen section control. 18. Rest of specimen. 2. "Esophagus." Received in formalin in a large container is a 6.1 cm long. 3.2 cm wide and approximately 0.6 cm deep. Esophagus is attached to a 7 x 4 x 3 cm portion of stomach and attached fibroadipose tissue. The esophageal mucosa is pink to grey and folded. At the gastroesophageal junction is a 2 x 2 cm tirm, white-tan, ulcer. This lies 5 cm from the esophageal margin and 2 cm from the gastric margins of resection. The radial margin is inked black. The rest of the gastric mucosa is tan-brown with appropriate rugae. Cut sections reveal a white-tan tumor which abuts the inked black radial margin. At this point, the tumor is 0.7 cm thick. At least two lymph nodes are identitied in the paraesophageal fat up to 1.5 x 1.1 x 0.6 cm. 2A through 2E. Tunor and esophaaus. 2F. Tumor to stomach. 2G. Gastric margin of resection. 2h. Possible lymph node. 2I & 2J. One bisected lymph node each. 3. "proximal cervical esophageal margin." Received in formatin in a small container is a 1 cm length of proximal esophagus, 1.5 x 1.5 cm. Surgical staples present.d 4. "Paraesophageal lymph node. Received in formalin in a small container is a 0.5 cm tan bit.. 5. "Celiac assess lymph node." Received in formalin in a small container is a 1 x 0.8 x 0.5 cm tan-white lymph node. FROZEN SECTION REPORT: Hyperplastic thyroid tissue with macro follicles.
+
+--- Page 2 ---
+PREVICUS DIAGNOSIS INQUIRY PAGE #: SEX: F REPORT DATE: PATIENT NBR: NAME: ADM DATE: BirThDATe: REQ DOC: OPER DATE: ACCESSION:  have reviewed and interpreted the trozen section material at the time it was requested. Permanent sections contirm frozen section report. VERIFIED By: PROCEDURE: ESOPHAGEAL, CARDIAC AND GASTROESOPHAGEAL JUNCTION CARCINCMA: Type of carcinoma: Adenocarcinoma If adenocarcinoma, it is arising in: Ge junction Depth of invasion: Muscularis propria Number of positive lymph nodes: 1/5 Extranodal metastasis: Unknown Pattern ot invasion: Expansile. Esophageal and gastric resection margins involved: No Deep resection margin involved: No TNM classification: T2 N1 Mx VERIFIED BY: PROCEDURE: 2 & 3. Esophagus, resection: Adenocarcinoma arising at the GE junction. Surgical margins free. Please see template for details. 4. Paraesophageal soft tissue, excision: Skeletal muscle. No lymph node present. 5. Celiac lymph node, excision: One lymph node negative for metastatic carcinoma. 1. Soft tissue of left cervix, excision: Hyperplastic thyroid tissue.
+
+--- Page 3 ---
+PREVIOUS DIAGNOSIS INQUIRYE PAGE #: Report DAte: SEX: F PATIENT NBR: NAME: ADM DATE: BirThDATE: REQ DOC: OPER DATE: AccESSION: the signing statf pathologist, have personally examined and interpreted the slides from this case.. Code: ********** ** END OF PREVIOUS DIAGNOSIS INQUIRY **S w.i13
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diff --git a/output/text/078c71e3-f13c-418a-b817-6da074f2cab6.txt b/output/text/078c71e3-f13c-418a-b817-6da074f2cab6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b9184c3242ff30cefe2f15351b79cfcb43f50cf3
--- /dev/null
+++ b/output/text/078c71e3-f13c-418a-b817-6da074f2cab6.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Pathology Report CORRECTED PATIENT HISTORY: Metastases -squamous cancer left neck. Primary unknown. PRE-OP DIAgNosIS: Cancer of pharynx. POST-OP DIAGNOSIS: Same. CeDure: Biopsy-tonsillectomy. ADDENDA: Addendum In situ hybridization for Human Papilloma Virus is positive. My si estation that I have personally reviewed the. submitted material(s) and the above diagnosis reflects that evaluation. FINAL DIAGNOSIS: PART 1: BASE OF TONGUE, LEFT, BIOPSY A. SQUAMOUS MUCOSA WITH LYMPHOID TISSUE. B. NO TUMOR SEEN. PART 2: TONSIL, LEFT, TONSILLECTOMY INVASIVE SQUAMOUS CELL CARCINOMA,AT LEAST 2.1 CM, MODERATELY TO POORLY DIFFERENTIATED, EXTENDING TO EXCISION MARGIN (See COmment). PART 3: TONSIL, RIGHT, TONSILLECTOMY A. HYPERPLASTIC TONSIL. NO TUMOR SEEN. HPv in situ hybridization is ordered and result will be reported in an addendum. According to the history, the greatest portion of this tumor was banked by Dr. per prior to receiving the specimen in pathology.
+
+--- Page 2 ---
+My signature is attestation that I have personally reviewed the submitted material(s) and the final diagnosis reflects that evaluation.. GROSS DESCRIPTION: The specimen is received in 3 parts.. Part 1 is received fresh labeled with the patient's name, initials xxx and "left tongue base".  Received are multiple, pink, irregular soft, tissue fragments ranging in size from 0.2 to 0.7 cm in greatest dimension. The specimen is entirely submitted for processing in a cassette labeled 1A. Part 2 is received fresh labeled with the patient's name, initials xxx and "left tonsil". Received is a 3.1 X 2.2 x 1.5 cm tonsil covered by tan- white, convoluted, squamous mucosa overlying tan- ivory, rubbery, tissue. Specimen is inked and serially sectioned and revealing a well-circumscribed, tan, gritty, tumor measuring 2.1 x 2.0 x 1.4 cm and approaching the deep resection margin by less than 0.1 cm. Greater portion of the tumor and specimen was banked as per prior to receipt in pathology lab. Remaining tissue is entirely submitted in cassettes labeled: 2A - tumor in relationship to resection margin 2B - remaining deep resection margin.. Part 3 is received fresh labeled with the patient's name, initials xxx and "right tonsil". Received is a 2 x 1.2 x 0.9 cm tonsil covered by tan- white, convoluted, squamous mucosa overlying tan-pink, unremarkable, soft, tissue. Specimen is inked and serially sectioned and reveals slightly lobulated, possible tonsillar crypts. No definitive tumor is noted. Specimen is entirely mitted in cassettes labeled 3A-3B. opic examination substantiates the above diagnosis. The following statement applies to all immunohistochemistry, Insitu Hybridization Assays (Ish & FIsh), Molecular Anatomic Pathology, and Immunofluorescent Testing:. The testing was developed and its performance characteristics dete the Department of Pathology, as required by. regulations. The testing has not been cleared or approved for the cific use by the U.S. Food and Drug Administration, but the FDA has determined such approval is not necessary for clinical use.
+
+--- Page 3 ---
+This laboratoi. certified under the Clinical Laboratory Improvement. Amendments of. ("cLIA") as qualified to perform high-complexity. clinical testing. Pursuant to the requirements of cLIA, AsR's used in this laboratory have been established and verified for accuracy and precision.. Additional information about this type of test is available upon request.. HISTO TISSUE SUMMARY/SLIDES REVIEWED: Part 1: Taken: Received: Stain/c HHE x 1 A H&E x 1 A Part 2: Taken: Received: Stain/c IHPV x 1 A IBNKNC x 2 A H&E x 1 A IISH x 1 A H&E x 1 B Part 3: Taken: Received: Stain/cn H&E x 1 A x 1 B
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diff --git a/output/text/07c2a129-09b6-4f8a-b624-81e4cdaa08dd.txt b/output/text/07c2a129-09b6-4f8a-b624-81e4cdaa08dd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..34c8c3453244258c4c36fc29cd37ae1a60af32c5
--- /dev/null
+++ b/output/text/07c2a129-09b6-4f8a-b624-81e4cdaa08dd.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Clinical Diagnosis & History: Rt kidney mass. Specimens Submitted: 1:SP:Kidney,right and perihilar nodesand right liver,radical nephrectomyliver wedge resectionand lymph node dissection SPLymph node.paracavalexcision DIAGNOSIS: 1.SP:Kidneyright and perihilar nodesand right liver,radical nephrectomy,liver wedge resection,and lymph node dissection TumorType: Renal cell carcinoma-Chromophobetype Tumor Size: Greatest diameter is 10.5 cm. Local Invasion (for renal cortical types) Not Identified Renal Vein Invasion: Not identified Surgical Margins: Free of tumor Non-Neoplastic Kidney: Unremarkable Adrenal Gland: Not involved Liver is not involved Lymph Nodes: Free of tumor Number of nodes examined:1 Staging for renal cell carcinoma/oncocytoma: pT2 Tumor >7.0 cm in greatest dimension limited to the kidney 2.SP:Lymph node,paracaval, excisior Lymph Nodes: Page 1of3
+
+--- Page 2 ---
+SURGICAL PATHOLOGYREPORT Not involved Number of nodes examined:1 IATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL)AND THAT IHAVE REVIEWEDAND APPROVED THIS REPORT. Gross Description: 1).The specimen is received fresh labeled "Right kidney,Perihilar nodes, wedge resection right liver" and consists of a kidney with attached ureter,renal vessels,perinephric fat, portion of liver, and adrenal gland. The total post fixation weight of the specimen is 900 g.The overall dimensions of the specimen are 16.5x 12 x 10.5 cm.The attached ureter measures 3.5 cm in length and 0.4 cm in diameter. The attached renal vein measures 1.0 cm in length and 0.9 cm in diameter.The renal vessels and ureter margins are grossly unremarkable. An adrenal gland is identified, measuring 5 x 2.3 x 0.7 cm.On cut section of the adrenal gland, it shows an unremarkable bright orange cortex measuring up to O.3 cm in thickness.The segment of liver, which is identified on the upper pole of the kidney,measures 6.5 x 3.2 x 0.9 cm.The resected margins of the liver are inked blue.The kidney is inked black and bivalved to reveal a markedly necrotic pink tan tumor measuring 10.5 x 9.5 x 9.5 cm. The tumor extends from the upper pole to the mid pole of the kidney,and on cut section abuts the black inked surface and is located O.4 cm the blue inked surface Further sectioning through the tumor shows a septated cystic appearance, and focal hemorrhagic calcified areas.The tumor appears to be well-circumscribed, and impinges on but does not show definite involvement of the renal pelvis and collecting ducts, renal vein,and sinus fat. Sections through the remainder of the kidney reveal a pink brown parenchyma,with a well-defined corticomedullary junction.The cortex measures 2.5 cm and the calyces appear normal.On complete opening of the ureter,renal pelvis,and collecting ducts, they show unremarkable white-tan mucosa.A single lymph node is identified in the perinephric fat, measuring 1.5 x 1.5 cm in greatest dimensions. The specimen is photographed.Representative sections are submitted for TPS and for permanent sections. Summary of sections: UM-ureteral margin VM-vessel margins LN-lymph node,serially sectioned T-tumor TSF-tumor with sinus fat TA-tumor and adrenal TL-tumor and liver TP-tumor and renal pelvis and collecting ducts TV-tumor and adjacent renal vein TC-tumor and black inked surface TN-tumor and normal kidney RS-representative sections of uninvolved kidney parenchyma ADR-representative sections of adrenal gland 2).The specimenis received in formalin, labeled "Paracaval lymph nodes"and consists of a single pink-tan, fatty lymph node measuring 2.7 x2x 1 cm.The lymph node is dissected into four pieces and entirely submitted. Summary of sections: BLN- dissected in four pieces (lymph node) Summary of Sections: Part 1: SP:Kidney,right and perihilar nodesand right liver,radical nephrectomy,liver wedge resection,and lymph node dissection Block Sect.Site PCs Page 2of3
+
+--- Page 3 ---
+SURGICAL PATHOLOGY REPORT 1 ADR 1 2 21 In 1 RS 3 T 3 2 TA 2 2 TC 2 TL 2 1 TN 1 2 TP 2 2 TSF 2 TV 2 1 um 1 1 vm 1 Part 2:SP:Lymph node,paracaval,excision Block Sect.Site PCs 4 BLN 4 Page 3of 3 ENDOFREPORT
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diff --git a/output/text/07cb045a-aaa2-4b58-8b28-29c2807d4590.txt b/output/text/07cb045a-aaa2-4b58-8b28-29c2807d4590.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3c1e7c15f8922eb6c10cbe7fdcff2231071bdac0
--- /dev/null
+++ b/output/text/07cb045a-aaa2-4b58-8b28-29c2807d4590.txt
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+
+--- Page 1 ---
+UUID:CF3CAF90-808C-4414-ADDF-7963C2F21D5E TCGA-2Z-A93P-01A-PR Redactedd Pathology Report Final Diagnosis A FAT ADJACENT TO TUMOR: Adipose tissue,no evidence of malignancy B DEEP MARGIN LEFT KIDNEY: Renal parenchyma, no evidence of malignancy. C LEFT KIDNEY, PARTIAL NEPHRECTOMY: Renal cell carcinoma, papillary type Il. See Key Pathologic Findings. Surgical margins,free of malignancy. Pathologic stage: pT1a NX MX. the attending pathologist, personally reviewed all siides and / or materials and rendered the tinal diagnosis. Electronically Signed out by 140.3 Key Pathological Finding.. C: Kidney Resection 8260J3 PROCEDURE:  Partial nephrectomy Sut, Fidney NoS. SPECIMEN LATERALITY: Left C%4.9 TUMOR SiZE (largest tumor if multipie): Dimension:1.5 cm h 4/28J4 MACROSCOPIC EXTENT OF TUMOR: Tumor limited to kidney HISTOLOGIC TYPE: Papillary renal cell carcinoma SARCOMATOID FEATURES: Not identified TUMOR NECROSIS:  5% HISTOLOGIC GRADE (Fuhrman Nuclear Grade): G3: Nuclei very irregular, approximately 20 microns; nucleoli large and prominent MICROSCOPIC TUMOR EXTENSION Tumor limited to kidney MARGINS: Margins uninvolved by carcinoma. ADRENAL GLAND: Not present PERINEURAL INVASION: Absent ANGIOLYMPHATIC INVASION:
+
+--- Page 2 ---
+Absent LYMPH-VASCULAR INVASION: Absent PRIMARY TUMOR (pT): pT1a:Tumor 4 cm or less in greatest dimension, limited to the kidney  REGIONAL LYMPH NODES (pN): pNX:Regional lymph nodes cannot be assessed DISTANT METASTASIS (pM): pMX Specimen(s) Received A FATADJACENT TOTUMOR B DEEP MARGIN LEFT KIDNEY FS C LEFT PARTIAL NEPHRECTOMY FS Preoperative Diagnosis Left renal mass Intraoperative Consultation FSB. MARGIN LEFT KIDNEY: No evidence of malignancy.. FSC1. LEFT PARTIAL NEPHRECTOMY: Carcinoma, margin negative. Comment: This frozen section diagnosis/result was communicated to and acknowledged by Dr have performed the intraoperative consuitation and issued the above diagnosis. Gross Description A. Specinen A is labeled "fat adjacent to tumor". The specimen is received fresh and consists of a 3 x 2 x 1 cm, soft, yellow-tan irregular fragment ot adipose tissue which is sectioned and entirely. submitted asA1 and A2 B. Specimen B is received fresh for frozen section analysis labeled deep margin left kidney The specimen consists of a 1 x 0.2 x 0.1 cm, saft, brown-tan irregular fragment of renal parenchyma. which is entirely submitted for frozen section as FsB1. C Specimen C is received fresh for frozen section analysis labeled "left partial nephrectomy*.. The specimen is received fresh and consists of a 2.5 x 2.5 x 1 cm, rubbery, brown-tan irregular. fragment of renal parenchyma. The surgical margin of resection is marked with black ink. Serial sections reveal a soft,bright-yellow mass (1.5 x 1 x 1 cm). The remainder of the cut surface consists of a red-brown grossty unremarkable renal parenchyma. A representative section of the tumor is submitted to Tissue Procurement Laboratory. A representative frozen section is taken and submitted as FsC1. The remaining tissue is entirely submitted as: C2: Mirror image of tumor submitted to Tissue Bank C3-C7: Remainder of the specimen. 1/3/14 Primary Tumor Site Disc HIPAA Disc
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diff --git a/output/text/07d32e93-f2df-46d5-9547-4be5ac4b3f37.txt b/output/text/07d32e93-f2df-46d5-9547-4be5ac4b3f37.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a2be402abf500211eb1e50289c9fdcdace719c6e
--- /dev/null
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+
+--- Page 1 ---
+DIAGNOSIS (A) BASE OF TONGUE:  INVASIVE POORLY DIFFERENTIATED SQUAMOUS CARCINOMA. (B) TISSUE OVERLYING LEFT INTERNAL JUGULAR VEIN: Connective tissue, no tumor present. (C) CONTENTS OF LEFT FUNCTIONAL NECK DISSECTION, TOTAL LARYNGECTOMY, TOTAL GLOSSECTOMY, RIGHT HEMIMANDIBULECTOMY: POORLY DIFFERENTIATED SQUAMOUS CARCINOMA OF SUPRAGLOTTIC LARYNX. (SEECOMMENT) LEFT FUNCTIONAL NECK DISSECTION WITH 1 OF 1O LYMPH NODES POSITIVE FOR METASTATIC POORLY DIFFERENTIATED SQUAMOUS CARCINOMA AND SOFT TISSUE EXTENSION IN SUBDIGASTRIC COMPARTMENT, SEPARATE FROM THE PRIMARY TUMOR. ZONE 2(SUBMENTAL-SUBMAXILLARY COMPARTMENT): 1 OUT 2 LYMPH NODES POSITIVE FOR METASTATIC POORLY DIFFERENTIATED SQUAMOUS CARCINOMA. Sublingua1 gland: Salivary gland, no tumor present. SubmandibuTar gTand: SaTivary gland, no tumor present. ZONE 3 (SUBDIGASTRIC COMPARTMENT): POORLY DIFFERENTIATED SQUAMOUS CARCINOMA IN FIBROCONNECTIVE SOFT TISSUE SHOWING LYMPHATIC INVASION. Eight lymph nodes, no tumor present. Right posterior soft tissue margin of mandible: Suture granulomas. with foreign body reaction.. (D) RIGHT PHARYNGEAL MARGIN, BIOPSY: Squamous mucosa and skeletal muscle, no tumor present. (E) RIGHT SOFT PALATE,EXCISION: Squamous mucosa and salivary gland, no tumor present.. (F) RIGHT NASOPHARYNGEAL BIOPSY: Squamous and respiratory mucosa and salivary gland, no tumor present. commenT: The tumor essentially replaces the entire vallecula with involvement of the epiglottis, right lateral glossoepiglottal fold, as wel1. as the right palatoglossal arch. The tumor extends to the epiglottic. cartilage and' is present in the supraglottic space. A discrete second tumor nodule on the left aryepiglottic fold is accompanied by underlying lymphatic permeation. Extensive tumoral permeation of !ymphatics alongside the entire mucosal margin or resection of the pyriform sinus bilaterally as wel7 as the anterior soft tissue margin underneath the oral mucosa. The tumor is Page 1 of 3 History Case Pathology Report History Case Pathology File under: Pathology
+
+--- Page 2 ---
+associated multifocally with in situ squamous carcinomas and varying aegrees. of dysplasias.. Grossly no tumor is appreciated crossing the mandibular. periosteum.  The anterior boney margin of segmental mandibulectomy specimen free of any tumoral involvement. DIAGNOSIS (A) BASE OF TONGUE: INVASIVE POORLY DIFFERENTIATED SQUAMOUS CARCINOMA. (B) TISSUE OVERLYING LEFT INTERNAL JUGULAR VEIN: Connective tissue, no tumor present. (C) CONTENTS OF LEFT FUNCTIONAL NECK DISSECTION, TOTAL LARYNGECTOMY,TOTAL GLOSSECTOMY,RIGHT HEMIMANDIBULECTOMY: POORLY DIFFERENTIATED SQUAMOUS CARCINOMA OF SUPRAGLOTTIC LARYNX. SEECOMMENT) LEFT FUNCTIONAL NECK DISSECTION WITH 1 OF 10 LYMPH NODES POSITIVE FOR METASTATICPOORLY DIFFERENTIATED SQUAMOUS CARCINOMA AND SOFT TISSUE EXTENSION IN SUBDIGASTRIC COMPARTMENT, SEPARATE FROM THE PRIMARY TUMOR. ZONE 2 SUBMENTAL-SUBMAXILLARY COMPARTMENT):1OUT 2 LYMPH NODES POSITIVE_FOR METASTATIC POORLY DIFFERENTIATED SQUAMOUS CARCINOMA. Sublingual gland: salivary gland, no tumor present.. Submandibular gland: salivary gland, no tumor present. ZONE 3 (SUBDIGASTRIC COMPARTMENT):POORLY DIFFERENTIATED SQUAMOUS CARCINOMA IN FIBROCONNECTIVE SOFT TISSUE SHOWING LYMPHATIC INVASION. Eight lymph nodes, no tumor present. Right posterior soft tissue margin of mandible: Suture granulomas with foreign body reaction. (D) RIGHT PHARYNGEAL MARGIN, BIOPSY: Squamous mucosa and skeletal muscle,no tumor present. (E) RIGHT SOFT PALATE,EXCISION: Squamous mucosa and salivary gland, no tumor present. (F) RIGHT NASOPHARYNGEAL BIOPSY: Squamous and respiratory mucosa and salivary gland, no tumor present. COMMENT The tumor essentially replaces the entire vallecula with involvement of the epiglottis, right lateral glossoepiglottal fold, as well as the right palatoglossal arch.  The tumor extends to the epiglottic cartilage and is present in the supraglottic space. A discrete second tumor nodule on the left aryepiglottic fold is accompanied by underlying 1ymphatic permeation. Extensive tumoral permeation of 1ymphatics alongside the entire mucosal margin or resection of the pyriform sinus bilaterally as well as the anterior soft tissue margin underneath the oral mucosa.. The tumor is associated multifocally with in situ squamous carcinomas and varying degrees of dysplasias. Grossly no tumor is appreciated crossing the mandibular periosteum. The bone margins of resection wil! be issued in an addendum anort after appropriate fixation and decalcification of the mandibular bone. Page 2 of 3 History Case Pathology Report History Case Pathology. File under: Pathology
+
+--- Page 3 ---
+SPECIMEN (A) BASE OF TONGUE: (B) TISSUE OVERLYING LEFT INTERNAL JUGULAR VEIN: (c) CONTENTS OF LEFT FUNCTIONAL NECK DISSECTION, TOTAL LARYNGECTOMY, TOTAL (D) RIGHT PHARYNGEAL MARGIN, BIOPSY: (E) RIGHTS SOFT PALATE, EXCISION: (F) RIGHT NASOPHARYNGEAL BIOPSY: Page 3 of 3 History  Case Pathology History Case Pathology Report File under: Pathology
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diff --git a/output/text/07dadb44-7656-4bf9-ab17-01628367a82a.txt b/output/text/07dadb44-7656-4bf9-ab17-01628367a82a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c07aff8542e0896a0c102cadc80ff891b2fd0aa8
--- /dev/null
+++ b/output/text/07dadb44-7656-4bf9-ab17-01628367a82a.txt
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+
+--- Page 1 ---
+1cD-0- 3 Carcinmmn, nfil+reting duct,Nos 85oof3 Sitews: sreest, nos C5o.9 12/2110 Final Diagnosis Breast/ left, lumpectomy: Infiltrating ductal carcinoma, Nottingham grade III (of IIl), [tubules 3/3, nuclei 3/3, mitoses 2/3; Nottingham score 8/9], forming a 1.8 x 1.5 x 1.5 cm mass [AJCC pT1c]. Angiolymphatic invasion is present. The non-neoplastic breast parenchyma shows. nonproliferative fibrocystic changes. Changes consistent with prior core biopsy site. All surgical resection margins, after re-excision of the superior margin, are negative for tumor (minimum tumor free margin, 0.5 cm, deep margin). Lymph nodes, left axilla, axillary dissection: Multiple 5 (of 14) left axillary lymph nodes are positive for metastatic carcinoma with extranodal extension (AJCC pN2).. UUID:747FB918-F523-4FA0-91DD-6014EF55643D Redacted
\ No newline at end of file
diff --git a/output/text/07eb7073-1c03-4285-a3f6-655580be36a5.txt b/output/text/07eb7073-1c03-4285-a3f6-655580be36a5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a8f8274fdf6ce5afdfed318b1ab2c33c85d2e81c
--- /dev/null
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+--- Page 1 ---
+1cD-0-3 cascinomn mifi1+natng duct; NOs 8500/3 Site: brenst. Nos c50.9 UUID:85045216-10EC-473C-96A9-268E71D28566 bS 5T19f11 Reda acted page 1 / 1 copy No. Date: Examination: Histopathological examination Internal invoice No. Value of diagnostic procedure. Examination No.: Patient: xXx PESEL: XXX Age Gender: F Material: Total organ resection-- teft breastg Unit in charge: Physician in charge: Material collected on: Material received on: Expected time of examination: up to 8 working days Clinical diagnosis: Cancer of the left breast. PCI: Cellulae carcinomatosae.  Examination performed on. Results of immunohistochemical examination: No estrogen receptors found in the neoplastic cell nuclei.. No progesterone receptors found in the neoplastic cell nuclei. HER2 protein stained with HER2 protein stained with Ventana's Pathway HER-2/neu (4B5) Rabbit Monoclonal Antibody.. Negative reaction in invasive cancerous cells (Score=0).. dr Compliance validated by: Examination performed on:. Macroscopic description: Left breas sized 17.3 x 15.4 x 4.8 cm removed without axillary tissues and with a skin flap of 17.3 x 6.3 cm. Weight 600 g. Tumour sized 1.6 x 1.2 x 1.8 cm found in the upper outer quadrant, located 3.8 cm from the upper boundary, 1.2 cm from the base and 1.6 cm from the skin.. Microscopic description: Carcinoma ductale invasivum. NHG3 (2 + 3 +3: 30 mitoses/10 HPF - visual area: 0.55mm). Glandular texture showing parenchymal atrophy Histopathological Diagnosis: Carcinoma ductale invasivum mammae sinistrae: Invasive ductal carcinoma of the left breast/(NHG3, pTIc, pNO (SN). Compliance validated by:
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diff --git a/output/text/07ecae46-342f-482f-af24-77c5a0c385b0.txt b/output/text/07ecae46-342f-482f-af24-77c5a0c385b0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..645cbd3d61f4edb65ab0eaac00a4641310f29263
--- /dev/null
+++ b/output/text/07ecae46-342f-482f-af24-77c5a0c385b0.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Lurcinoma, vnyu,'nyinf cuc ak NU Sit: beast, Nos cso.9 lu :urgicat Patl Surg Path CLINICAL HISTORY: Large primary tumor left breast. GROSS EXAMINATION: A. "Left breast biopsy", received fresh. Fibroadipose tissue 5.4 x 4 cm containing a central infiltrative yellow white stellate tumor 3 cm in diameter. Al- AFl. Representative sections in Block A2-A4. B. "Left breast", fresh. A breast measuring 23 x 15 x 6 cm with an overlying skin ellipse 17 x 9 cm. There is a retracted nipple toward the medial aspect.. A sutured incision 6 cm across is present towards the lateral aspect. Numerous slightly elevated brown warty lesions are present on the skin adjacent to the nipple. Attached axillary tissue is present measuring 13 x 3 x 5 cm and this contains numerous enlarged lymph nodes, the largest of which measures 2.5 cm across. The largest three nodes have been marked with a suture and bisected. Sectioning the breast shows a cavity beneath located in the upper outer quadrant the incision measuring 5 cm in diameter. The deep margin is 0.5 cm from the deep edge of the cavity. None of these tumor tissues is present within wall. The remaining breast tissue is irregular fibrous but shows no suspicious lesions. Block Summary: B1- nipple and adjacent skin lesions. B2- nipple. UUID:D792031E-2CCE-4341-83B3-C7D1D84F8F6B B3- deep margin. TCGA-B6-A0X1-01A-PR Redacted B4, B5- cavity wall. B6- lower outer quadrant.. B7- lower outer quadrant.. B8- upper inner quadrant. B9- upper outer quadrant. B10- one lymph node lower axilla. B11, B12- one lymph node .. B13- fibrous tissue mid axilla. B14, B15- two lymph nodes.. B16- three lymph nodes. B17- four lymph nodes. B18- four lymph nodes upper axilla. B19- four lymph nodes. B20- two lymph nodes. INTRA OPERATIVE CONSULTATION: AF1 "Invasive ductal carcinoma". Tissue sent for ER/PR. MICROSCOPIC EXAMINATION: Sections show poorly differentiated invasive ductal carcinoma of no special type invading breast tissue. The tumor is composed of highly atypical. pleomorphic epithelial cells forming sheets, cords, and columns with minimal attempt at the gland formation. There is extensive lymphatic channel invasion by tumor, and extensive tumor necrosis is present.. DIAGNOSIS: A. "LEFT BREAST BIOPSY":  INVASIVE_DUCTAL CARCINOMA OF NO SPECIAL TYPE MEASURING 3 CM ACROSS. NSABP NUCLEAR GRADE 3, HISTOLOGIC GRADE 3. EXTENSIVE LYMPHATIC CHANNEL INVASION AND TUMOR NECROSIS IS PRESENT.
+
+--- Page 2 ---
+NO ADJACENT IN SITU CARCINOMA PRESENT.S B. "LEFT BREAST BIOPSY", LEFT RADICAL MASTECTOMY.:S BIOPSY CAVITY WALL CONTAINS RESIDUAL HIGH GRADE INVASIVE DUCTAL CARCINOMA OF NO SPECIAL TYPE SIMILAR TO THE ABOVE TUMOR. DEEP MARGIN IS FREE OF TUMOR. NIPPLE AND NIPPLE DUCT ARE FREE OF TUMOR. SEPARATE FOCI OF TUMOR IS IDENTIFIED IN THE UPPER INNER QUADRANT, REPRESENTING MULTIFOCAL TUMOR. METASTATIC TUMOR PRESENT IN 16 OF 21 LYMPH NODES WITH EXTRACAPSULAR INVASION OF TUMOR PRESENT. (3 OUT OF 4 LOWER AXILLA, 9 OUT OF 11 MID AXILLA, 4 OUT 6 UPPER AXILLA) MULTIPLE SEBORRHEIC KERATOSIS ON SKIN ADJACENT TO NIPPLE. Verified by:. (Electronic Signature) Date Signed:
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diff --git a/output/text/080b7aeb-c462-4352-b521-535af0ebf705.txt b/output/text/080b7aeb-c462-4352-b521-535af0ebf705.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c5287167819809eb426327dae6a90e232b1048a3
--- /dev/null
+++ b/output/text/080b7aeb-c462-4352-b521-535af0ebf705.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+SURGICAL PATHOLOGY REPORT Accession number Final Report DIAGNOSIS: 1) LYMPH NODES, LEVEL 2 & 3, RIGHT NECK, EXCISION: 21 LYMPH NODES, NEGATIVE FOR MALIGNANCY (0/21). 2) LYMPH NODES, LEVEL 1B AND PERIFASCIAL NODE, LEFT, EXCISION: SALIVARY GLAND AND 2 LYMPH NODES, NEGATIVE FOR MALIGNANCY (0/2). 3) LYMPH NODES, LEVEL 2 & 3, LEFT NECK, EXCISION: 26 LYMPH NODES, NEGATIVE FOR MALIGNANCY (0/26). 4) LYMPH NODES, LEVEL 1A, NECK, EXCISION: 4 LYMPH NODES, NEGATIVE FOR MALIGNANCY (0/4). 5) TONGUE AND RIGHT LEVEL 1, RESECTION: MODERATELY DIFFERENTIATED INVASIVE SQUAMOUS CELL CARCINOMA OF THE TONGUE, 7.5 CM IN GREATEST DIMENSION; ALL SURGICAL MARGINS NEGATIVE FOR MALIGNANCY (TUMOR EXTENDS TO WITHIN 0.3 CM OF RIGHT SURGICAL MARGIN); PERINEURAL INVASION PRESENT; 4 LYMPH NODES, NEGATIVE FOR MALIGNANCY (O/4) (SEE COMMENT & SUMMARY FINDINGS). Upper Aerodigestive Tract and Minor Salivary Glands Carcinoma. Summary of Findings: Specimen Type: total glossectomy & neck lymph node dissection. Tumor Site: tongue Tumor Size: 7.5 cm in greatest dimension Histologic Type: squamous cell carcinoma Histologic Grade: moderately differentiated (grade II/III) Pathologic Staging (pTMN): IVA Primary tumor (pT): pT4 Regional Lymph Nodes (pN): pN0 Number examined: 57 Numbered involved: 0 Perineural invasion: present Bony/Cartilage Invasion: Not evaluable HPV testing ordered: Yes
+
+--- Page 2 ---
+COMMENT: These findings correspond to AJCC pathologic Stage IVA (pT4a, pN0. pMn/a). **Electronically Signed Out by M.D.** CLINICAL DATA Clinical Features: unspecified Operator: Operative Findings: unspecified Operative Diagnosis: unspecified. Tissue Submitted:1) right neck level 2,3, 2) left level 1B and perifascial node, 3) left neck level 2, 3; 4) neck dissection, level 1A; 5) total glossectomy, right level 1. GROSS DESCRIPTION: 1) SOURCE: Right Neck Level 2, 3 Received fresh, labeled "right neck level 2, 3," per requisition, is a 6.0 x 5.5 x 2.cm portion of partially circumscribed yellow-tan lobular adipose tissue with a nodularity noted on palpation. The dissected lymph nodes are submitted as follows: Summary of sections: 1A, 9 lymph nodes, 9/1; 1B, 2 lymph nodes, each bisected (1 inked black), 4/1; 1C, 2 lymph nodes each bisected (1 inked black) 4/1; 1D-1I, 1 lymph node, bisected, 2/1 each. 2) SOURCE: Left level 1B and perifascial node Received fresh labeled "left level 1B and perifascial node", per requisition, is a 5 x 4 x 1.6.cm portion of partially circumscribed. yellow-tan lobular adipose tissue with a nodularity noted on palpation. Serial sectioning shows a few circumscribed lymph nodes and a gold-tan trabecular cut surface consistent with a gland. Summary of sections: 2A, 4 lymph nodes, 4/1; 2B, section of gland tissue, 2/1. 3) SOURCE: Left Neck level 2, 3 Received fresh, labeled "left neck level 2, 3" per requisition, is a 5 x 4 x 1.8 cm aggregate of partially circumscribed yellow-tan lobular adipose tissue with a nodularity noted on palpation. Summary of sections: 3A, 5 lymph nodes, 5/1; 3B, 6 lymph nodes, 6/1; 3C, 2 lymph nodes, each bisected, (1 inked black), 4/1; 3D, 2 lymph nodes, each bisected 1 inked black), 4/1; 3E, 4lymph nodes, 4/1; 3F-3G, 1 lymph node bisected, 2/1 each. 4) SOURCE: Neck dissection level 1A Received fresh, labeled "neck dissection level 1A", per requisition, is a 4
+
+--- Page 3 ---
+x 3 x 1.2 cm portion of partially circumscribed, yellow-tan lobular adipose tissue with a nodularity noted on palpation. Summary of sections: 4A, four lymph nodes, 4/1 5) SOURCE: Total glossectomy right level 1 Received fresh in a container labeled with the patient's name and "total glossectomy right level 1" is a 224 gram total glossectomy specimen measuring 10.5 cm anterior to posterior by 9 cm from right to left by 6.2 cm from superior to inferior. There are no orientation instructions received along with the specimen. The specimen consists of a grossly identifiable tongue with a pink-tan, shaggy mucosal surface which measures 10.5 cm from anterior to posterior by 6.5 cm from right to left by approximately 3.5 cm superior to inferior. There is a small amount of adjacent pink-tan, shiny mucosa, which is consistent with the floor of the mouth. The surface of the specimen opposite the mucosa is pink-red, shaggy, and consistent with a surgical resection margin. Using anatomic landmarks for orientation, the specimen has been inked in the following manner: anterior is orange, posterior is black, right is red, left is yellow, and inferior is green. The mucosal surface is notable for an ulcerated, friable mass that is present on the right floor of mouth, extending to the lateral aspect of the tongue and measures approximately 7.5 x 5.0 cm in area. Grossly, the mass extends to within 1.0 cm of the right lateral margin and 1.5 cm of the anterior margin. The specimen is serially sectioned to reveal a cheesy, white-yellow mass extending approximately 4.0 cm deep to the ulceration and grossly extending to within 0.7 cm of the inferior inked margin, 0.3 cm of the right inked margin, 0.6 cm of the anterior inked margin, O.5 cm of the posterior inked margin, and appears widely free of the left inked margin. Representative sections are submitted for. evaluation. Summary of sections: 5A, left anterior mucosal margin and left anterior deep, 3/1; 5B, left lateral mucosal margin and left lateral deep, 2/1; 5C, left hypopharynx margin and left hypopharynx deep, 2/1; 5D, posterior mucosal margin and posterior deep, 2/1; 5E, right hypopharynx margin and hypopharynx deep, 2/1; 5F, right lateral mucosal margin and right lateral deep, 2/1; 5G-H, perpendicular sections of tumor approaching right lateral mucosal margin, 1/1 each; 5I-J, tumor approaching right anterior mucosal margin, 1/1 each; 5K, right anterior deep margin, 1/1; 5L, inferior margin, 1/1; 5M-N, representative sections of mass, 1/1 each; 5O,right floor mass 1/1; 5P, normal appearing posterior tongue, 1/1; 5Q, normal appearing left lateral tongue, 1/1; 5R, normal appearing anterior tongue, 1/1.. Dictated by (ASCP) for Dictated by Slides and report reviewed by Attending Pathologist..
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diff --git a/output/text/08104942-1ebb-4c07-9b39-cdeb1a7bcf85.txt b/output/text/08104942-1ebb-4c07-9b39-cdeb1a7bcf85.txt
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index 0000000000000000000000000000000000000000..f59f70e43f74215e043c1e830743cae59dc4db9f
--- /dev/null
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+i cs-0-3 Carcinoma, hifiltrating duct, NoS 8500|3 128/0 lw Poth cQeF Sin: busst, Nos C 50.9 UUID:FD8CDFD9-6DCF-4CE1-9BB1-A7FF568EE53C TSS TCGA-E2-A14P-01A-PR Redacted SPECIMENS: A. RIGHT AXILLARY CONTENTS B. RIGHT BREAST LUMPECTOMY C. RIGHT BREAST SUPERIOR MARGIN SPECIMEN(S): A. RIGHT AXILLARY CONTENTS B. RIGHT BREAST LUMPECTOMY C. RIGHT BREAST SUPERIOR MARGIN INTRAOPERATIVE CONSULTATION DIAGNOSIS: B. Right breast, lumpectomy (Gross examination only): 3.0 cm firm tumor, 1.5 cm from deep margin. Satellite tumor. 1 cm from main tumor, 1 cm in diameter (1.0 cm from antero medial margin). By Dr. called to Dr. at GROSS DESCRIPTION: A. RIGHT AXILLARY CONTENTSE  Received in formalin in a container labeled with the patient name designated "a. right axillary contents" is a portion of. red-yellow firm adipose tissue measuring 10.1 x 8.5 x 3.7 cm. Multiple firm enlarged lymph nodes are identified, ranging in size from 0.3 x 0.2 x 0.2 up to 3.5 x 2.5 x 2.0 cm. Cassettes are submitted as follows: A1-A2: representative sections, 1 lymph node A3-A5: 1 lymph node A6-A8: 1 lymph node A9-A10: 1 bisected lymph node A11: 1 bisected lymph node A12: 4 lymph nodes A13: 3 lymph nodes A14: 3 lymph nodes A15: 2 lymph nodes A16: 3 lymph nodes A17: 3 lymph nodes A18-A20: additional possible lymph nodes. B. RIGHT BREAST LUMPECTOMYE Received fresh is an oriented 226 gm lumpectomy specimen, 15 x 10 x 4 cm. The specimen is partially surfaced with a tan-pink ellipse of skin, 11.5 x 5.5 cm. The skin surface is grossly unremarkable. The specimen is inked as follows: anterior-blue, posterior-black, superior-red, inferior-orange, medial-green, lateral-yellow. Specimen is serially sectioned from superior to inferior into 6 slices; slice 1 being most superior, slice 6 being most inferior to. reveal a gray-white firm well circumscribed mass, 3.0 x 2.5 x 1.7 cm located in slice 2 and 3. Mass #1 measures 1.5. cm from the closest deep margin and 2.0 cm from the anterior margin. A 2nd possible satelite nodule is identified, 0.8 x 0.7 x 0.6 cm, 0.6 cm medial to mass #1 located in slice 2. .The 2nd mass measures <1.0 cm from all margins. The 2nd mass measures 0.6 cm from the medial margin. Mass #2 measures 0.6 cm from mass #1. The remaining. cut surface reveal predominantly yellow lobulated adipose tissue inter dispersed with gray-white fibrous tissue. A portion of the specimen is submitted for tissue procurement and representative sections are submitted as follows: B1: area immediately adjacent to mass #1 slice 1  B2: perpendicular sections of the superior margin slice 1 B3: lateral margin slice 2 B4: posterior margin slice 2 B5: mass #1 slice 2 B6-B7: mass #1, bisected slice 2 B8-B9: #2, bisected slice 2 B10: medial margin slice 2 B11: skin slice 2 B12: ateral margin slice 3 B13-B14: mass #2 slice 3 B15: area immediately adjacent to mass #2 slice 3 B16: medial margin slice 3 B17: skin slice 3 B18: posterior margin slice 3. B19: area immediately adjacent to mass #1 slice 4 B20: medial margin slice 4
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+B21: medial and posterior margin slice 5 B22: lateral margin slice 5  B23: perpendicular section taken of the inferior margin slice 6 as per attached diagram B24: posterior margin B25: superior margin C. RIGHT BREAST SUPERIOR MARGIN Received in formalin is a 12 gm oriented fragment of fibrofatty tissue, 9.0 x 3.0 x 1.5 cm. The new true margin is. inked blue and the specimen is serially sectioned to reveal grossly unremarkable breast parenchyma. Entirely submitted in cassettes C1-C10. DIAGNOSIS: A. AXILLARY CONTENTS, RIGHT, DISSECTION: - METASTATIC CARCINOMA TO 10 OF 24 LYMPH NODES WITH EXTRANODAL EXTENSION, LARGEST METASTASIS IS 3.5 CM (10/24) B. BREAST, RIGHT, LUMPECTOMY:  INVASIVE DUCTAL CARCINOMA WITH SATELLITE NODULE - SBR GRADE 3. - TUMOR MEASURES 3 CM AND 1.1 CM. - MARGINS, NEGATIVE FOR CARCINOMA. - LYMPHOVASCULAR INVASION IS PRESENT. - DUCTAL CARCINOMA IN SITU (DCIS), SOLID AND CRIBRIFORM TYPES, NUCLEAR GRADE 3, WITH COMEDO NECROSIS, MINOR COMPONENT. - SKIN, NEGATIVE FOR CARCINOMA. C. BREAST, RIGHT, SUPERIOR MARGIN, EXCISION: - BREAST TISSUE, NEGATIVE FOR CARCINOMA SYNOPTIC REPORT - BREAST Specimen Type: Excision Needle Localization: No Lateratity: Right Invasive tumor: Present Multifocality:  Yes WHO CLASSIFICATION  Invasive ductal carcinoma, NOS 8500/3 Tumor size: 3cm Tumor site: Upper outer quadrant Margins: Negative Distance from closest margin: Greater than 1cm all margins Tubular score: 3 Nuclear grade: 3 Mitotic score: 2 Modified Scarff Bloom Richardson Grade:. 3 Necrosis: Absent Vascular/Lymphatic Invasion: Present Lobular neoplasia: None Lymph nodes: Axillary dissection Lymph node status: Positive 10 / 24 Extranodal extension DCIS present Margins uninvolved by DCiS: 0.4 cm from medial margin, focal DCIS Quantity:Estimate 10% DCIS type: Solid Cribriform DCIS location: Both associated and separate from invasive tumor mass Nuclear grade: High Necrosis: Present ER/PR/HER2 Results Performed on Case: ER: Negative PR: Negative HER2: Positive by IHC Pathological staging (pTN): pT 2 N 3
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+SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimen: Surgical Excision Block Number: B14 ER: Negative Allred Score: 0 = Proportion Score 0 + Intensity Score 0 PR: Negative Allred Score: 0 = Proportion Score 0 + Intensity Score 0 COMMENT: The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring range from 0 to 8.. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2. Methodology: Fixation Type and Length: Tissue was fixed in 10% neutral buffered formalin. r) for no less than 8 and no longer than 24 hours. Antibody and Assay Methodology: Mouse anti-human ER and PR, Comment: This assay Ca.: t'e used to select invasive breast cancer patients for hormone therapy (1). ER and PR analysis was performed on this case by immunohistochemistry utilizing the ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) antibody provided by Dako, following the manufacturer's instructions listed in the package insert. This assay was not modified, and adherence to all instruction and guidelines were strictly followed. Interpretation of the ER/PR immunohistochemical staining characteristics is guided by published results in the medical literature (1). information provided by the reagent manufacturer and by internal review of staining performance within the Pathology Department 1. Harvey JM, et al. Estrogen receptor status by immunohistochemistry is superior to the ligand-binding assay for predicting response to adjuvant endocrine therapy in breast cancer. J Ctin Oncol. 17:1474-1481, 1999 SYNOPTIC REPORT - BREAST HER-2 RESULTS HER2 Status Results, Immunohistochemistry Evaluation Specimen: Surgical Excision Block Number: B14 Interpretation: POSITIVE Intensity: 3+ % Tumor Staining: 100% Fish Ordered: No METHODOLOGY Methodology: Fixation Type and Length: Tissue was fixed in 10% neutral buffered formalin. for no less than 8 and no longer than 24 hours. Antibody and Assay Methodology: Rabbit anti-human HER2, HerceptestTM (FDA-approved test kit), '.). Control Slides Examined: External kit-slides  provided by manufacturer (cell tines with gn, row ana negative HER2 protein expression), and in-house known HER2 amplified control tissue were evaluated along with the test tissue. These control slides run along side of this patient's sample showed appropriate staining. Adequacy of Specimen: Adequate, well preserved, clear-cut invasive carcinoma identified for HER2 evaluation. Scoring Criterion and Scoring System. IHC Level of Expression(Score) /Tumor Cell Membrane Staining Pattern.  Negative (O)/Absence of Staining  Negative (1+)/Faint Incomplete membrane Staining, >10% of Cells Equivocal (2+)/Weak complete membrane Staining, >10% of Cells Positive (3+)/Strong complete membrane Staining, >10% of Cells Equivocal Category for HER2 IHC results: A HER2, 2+ staining result that is interpreted as equivocal may not  indicate gene amplification. A FISH test for HER2 gene amplification will be ordered for all HER2 IHC 2+ results. COMMENT  This assay can be used to select invasive breast cancer patients for Trastuzumab (Hereptin) therapy (1,2). Clinical  Trials have shown that Trastuzumab substantially increases the likelihood for an objective response and overall.  survival for patients with metastatic HER2-positive breast cancer, regardless of whether HER2 tumor status was determined as iHC 3+ or FiSH positive. Trastuzumab added to adjuvant chemotherapy substantially increase disease-free survival and decreases the risk of disease recurrence by about 50% for patients with early-stage HER2  protein over-expressed or gene amplified invasive breast cancer (3).. HER2 analysis was performed on this case by immunohistochemistry utilizing the FDA approved Dako HercepTest (TM) test kit following the manufacturer's instructions listed in the package insert. This assay was not modified, and  adherence to allinstruction and guidelines were strictly followed. Interpretation of the HER2 immunohistochemical staining characteristics is guided by published results in the medical literature (4), information provided by the  reagent manufacturer and by internal review of staining performance within the Pathology Department. HER2 TEST VALIDATION This HER2 immunohistochemical assay has been validated according to the recently revised recommendations and  guidelines from the NCCN HER2 testing in Breast Cancer Task Force, and the jointly issued recommendations and
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+guidelines from ASCO and the CAP (5). 80 randomly selected breast cancer samples were tested for HER2 by IHC as outline above and interpreted as, negative (score 0/1+) equivocal (score 2+) and positive (score 3+) without knowledge of the previous reported results. HER2/CEP17 ratios were recorded. After analyzing these results, there was 100% concordance between the IHC and FISH results for cases that were interpreted as either positive or negative by IHC. 9 of the 80 cases were interpreted as equivocal by IHC and of these 3/9 (33%) were non-amplified by FiSH and 6/9 (66%) were found to be amplified. The Pathology Department Immunohistochemistry laboratory takes full responsibility for this tests performance and has programs in place to regularly monitor the proficiency and the interpretation of HER2 assays. The Iaboratory also participates in external quality assurance HER2 programs including the CAP proficiency testing program. REFERENCE 1. Carison RW, Anderson BO, Burstein HJ, et al., NCCN breast cancer clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2005;3:238-289. 2. Carlson Rw, Brown E, Burstein HJ, et ai., NCCN Task Force Report: adjuvant therapy for breast cancer. j Natl Compr Canc Netw. 2006;4:S1-S26 3. Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Eng J Med 2005;353(16):1673-84 4. Leong ASy, Formby M, Haffajee Z, et al. Refinement of immunohistologic parameters for Her2/neu scoring validation by FISH and CiSH. Appl Immunohistochem Mol Morphol. 2006;14:384-389. 5. Wolff AC, Hammond EH, Schwartz JN, et al., American Society of Clinical Oncology/College of American  Pathologists Guideline Recommendations for Human Epidermal Growth Factor Recepto 2 Testing in Breast Cancer. Arch of Path and Lab Med 2007; 131:18-43. CLINICAL HISTORY:  year old female with large right breast mass and satellite iesion (1 cm) anterior to main tumor. Now for lumpectomy. PRE-OPERATIVE DIAGNOSIS: None given Gross Dictation: Pathologist,. Microscopic/Diagnostic Dictation: Pathologist,e Gross Dictation: Pathologist,. Microscopic/Diagnostic Dictauon: Patnoiogisie Final Review: Pathologist,. Final: Pathologist,
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+UUID:17015647-C660-4661-B739-0A58A88FC1EB TCGA-VD-AA8R-01A-PR Redacted Department of Pathology , HISTOPATHOLOGY Surname Lab No. Cllnical Consultant & Location  DOB/Age Forename(s) Sex Unit No Request Date This Copy For: zD-O3 SPECIMEN LEFT GLOBE ENUCLEATION jmol 877013 Prognostic/diagnostic Sute; CCherwel C69.3 CLINICAL DETAILS YD 5/30114 Choroidal melanoma. No treatment.. See diagram. Measurements: 14.10 x 13.73 x (6.55)mm. MACROSCOPIC DESCRIPTION A fresh, intact, left globe.. Dimensions: Axial 24mm, Horizontal 24mm, Vertical 23mm Cornea: Horizontal 12mm, Vertical 11.5mm Optic nerve: flush. On trans-illumination, a large shadow is seen inferiorly, approximately 15mm in maximum dimension.. Plane of section: vertical. Intraocular description:. On opening, a solitary pale dome shaped choroidal mass is seen, with possible ciliary body involvement. Tumour size: LBD 13mm. Height 9mm. MICROSCOPY Sections show a virtually amelanotic melanoma consisting predominantly of spindle cells however also including a minor epithelioid cell component . up to 10%. The tumour occupies basically the choroid with focal extension to pars plana. Most of tumour cells are arranged in a fascicular pattern with nuclear palisading. In addition, there is focal cytoplasmic vacuolation in tumour cells producing a balloon cell appearance. The number of mitosis is approximately 4/40 high power Reported: Pathologist: Electronically Verified:
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+orinted: Department of Pathology Page 2 of 4  HISTOPATHOLOGY REPORT Tel: Surname Lab No Clinical Consultant & Location Forename(s) DOBiAge Sex UnIt No Request Date This Copy For:. fields. Closed loops are not present in the planes of sections. The lymphocytic infiltrate within the tumour is minimal. Few scattered macrophages are present. Tumour necrosis is not seen. Bruch's membrane appears focally breached in one of the sections. There is no tumour extension through the sclera, optic nerve or vortex veins examined. Tumour cells are not seen at the resection margins. Elsewhere,  the cornea shows no significant abnormality. The anterior chamber angles are open and the anterior chamber is shallow. The iris shows no significant abnormality but the ciliary body appears atrophic with hyalinisation of ciliary processes. The lens shows cataractuous changes. Retina overlying the tumour is slightly atrophic. DIAGNOSIS Left eye, enucleation: Ciliochoroidal melanoma of mixed cell type. COMMENT Assessment of Hsp27 expression on immunohistochemistry will follow. In addition, molecular genetic examination of DNA extracted from the tumour cells will be performed using multiplex-ligation dependent probe amplification (MLpA). looking at chromosomes 1, 3, 6 and 8.~A supplementary report will follow in due course. SUPPLEMENTARY REPORT (MLPA) In the meantime, molecular genetic analysis of tumour DNA extracted from the fresh uveal melanoma'tissue was performed using the technique termed multiplex ligation-dependent probe amplification (MLpA). These investigations were performed in the The kit p027 from. which examines for gains or losses in 31 loci on chromosomes 1, 3, 6 and 8, was used. The DNA concentration was measured using : and the quality assessed using multiplex-pCR prior to the MLPA reaction. Reported: Pathologist: Electronically Verified:.
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+inied. Department of Pathology Page 3 of 4 HISTOPATHOLOGY REPORT Tel:  Surname Lab No Clinical Consultant & Location Forename(s)  DOB/Age Sex Unit No Request Date This Copy For: The DNA concentration was high and of good quality on. assessment. The MLpA reaction was run at least twice on. differing occasions, resulting in similar results. The results of the sequence analysis of the MLpA products is. printed on a separate report. In summary, sequence analysis demonstrated: normal chromosome ip, disomy 3, borderline gains in chromosome 6 and normal chromosome 8. Taken together, these molecular data would place the patient in the low risk group with respect to the development of metastatic melanoma.  Consideration of clinical features of the tumour is, however, also required. SUPPLEMENTARY REPORT - Tumour cells express Melan-A and Hsp 27 (score 2).. SUMMARY SPECIMEN 2= Eye TUMOUR PRESENT Yes TUMOUR TYPE 1= Melanoma CELL TYPE 3= Mixed CT LOOPS 1= No closed loops NECROSIS No PIGMENTATION No LYMPHOCYTIC INFILTRATION NO MITOTIC FREQUENCY 4/40 HPF DIFFUSE MELANOMA NO SPREAD 1= No Reported: Pathologist: Electronically Verified:
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+rinted: Department of Pathology Page 4 of 4 HISTOPATHOLOGY REPORT Tel: Surname Lab No Clinlcal Consultant & Location Forename(s) DOB/Age Sex Unit No Request Date This Copy For: CLEARANCE 2= Adequate HSP-27 POSITIVITY 2= 21-70% LARGE DIAMETERS 13 mm THICKNESS 9 mm Reported: Pathologist: Electronically Verified:  :
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diff --git a/output/text/08381bb9-1b80-4d46-8cd4-585691351ce0.txt b/output/text/08381bb9-1b80-4d46-8cd4-585691351ce0.txt
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+UUID: F43B01E6-E1DB-44B1-8003-93870606346A TCGA-3C-AALK-01A-PR Redacted Name: Path No.: MRN: Date Obtained: D.O.B. (Age: Date Received: Sex: F Physician: Location: SURGICAL PATHOLOGY **See Addendum/Procedure** SPECIMEN: tcD 0 3 A:Subnipple tissue, right breast, excision B:Lymph node, right axilla sentinel node, biopsy srsnwn@) iyiltahiey dustNOS C:Lymph node, right axilla sentinel node #2, biopsy 85c0/3 D:Breast, right, total mastectomy OLiasb Nos E:$kin, right breast, excision Cs09 Breast, ertol pntiy DIAGNOSIS(ES): A. Subnipple tissue, right breast, excision:. YeJ 3/11/14 Nippie ducts with atypical micropapillary hyperplasia, No carcinoma seen. B. Lymph node, right axilla sentinel node, biopsy: Lymph node, bisected and serially sectioned, negative for carcinoma. IHC for cytokeratin is negative. C. Lymph node, right axilla sentinel node #2, biopsy: Lymph node, quadrasected and serially sectioned, single focus of carcinoma seen by light microscopy and lHC for cytokeratin (focus of < 10 cells, ITC). D. Breast, right, total mastectomy:  Infiltrating ductal carcinoma, well differentiated (1+2+1=4/9), spanning 2.0 cm, arising in a background of ductal carcinoma in situ, intermediate to high grade. Inflltrating ductal carcinoma, separate focus, moderately dlfferentiated (3+3+1=7/9), spanning 0.6 cm. Extensive ductal carcinoma in situ, solid, cribriform and micropapillary type, with necrosis and microcalcification, seen on 15 of 26 slides and extending to within 0.1 cm of deep margin. The micropapillary DCl$ is seen in the nipple duct sections. Lobular carcinoma in situ, monomorphic type.. Intraductal papillomas and sclerosing adenosis with microcalcification. Fibroadenoma E. Skin, right breast, excision: Fragments of skin.. CLINICAL INFORMATION: Right breast cancer. Gross description:. The specimen is received in five parts. Part A is received fresh from the operating room for frozen section diagnosis in a container labeled with the patient's name and "Rt subnipp!e tissue R/O cancer". It consists of one piece of red soft tissue measuring 1.1 x 0.9 x 0.3 cm. Page l of5
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+The specimen is entirely submitted in one cassette labeled AFS Part B is received fresh from the operating room for frozen section diagnosis in a container labeled with the patient's name and "Right axillary sentinel lymph node #1". It consists of one piece of fatty tissue measuring 3.2 x 1.4 x 0.8 cm. One lymph node is palpated measuring 1.8 cm in greatest dimension. The lymph node is bisected. The specirnen is entirely submitted in four cassettes labeled BFs1-BFs2, B1 and B2. Please note: Three levels and cytokeratin stains are ordered for the lymph node only. Legend: BFS1-BFS2 = frozen section-lymph node, B1-B2 = remaining tissue. Part C is received fresh from the operating room for frozen section diagnosis in a container labeled with the patient's name and "Right axillary sentinel lymph node #2". It consists of one piece of fatty tissue measuring 2.8 x 1.9 x 1.1 cm. One lymph node is palpated measuring 2.7 cm in greatest dimension. The lymph node is quadrisected. The specimen is entirely submitted in five cassettes labeled CFS1-CFS4 and C1. Please note: Three levels and cytokeratin stains are ordered for the lymph node only.. Legend: CFS1-CFS4 = frozen section-lymph node, C1 = remaining tissue. Part D is received unfixed in a container labeled with the patient's name and "Right breast mastectomy, stitch short anterior subnipple tissue, stitch long = lateral". It consists of a right total skin sparing mastectomy specirnen measuring 22.0 x 14.0 x 3.5 cm. A short suture is noted indicating the subareolar and a long suture is noted indicating the superior (as per Dr. , the long suture was mistakenly labeled "lateral"). An underlying mass is palpable located 1.0 cm. from the subareolar. The subareolar is inked blue, the superficial margin is inked yellow and the deep margin is inked black. The axillary tissue measures 2.5 x 1.5 x 0.5 cm. No lymph nodes are palpable within it.. The specimen is serially sectioned at closely spaced intervals, revealing an area of white, cystic parenchyma measuring 6.0 x 4.0 x 2.5 cm located in the center, 0.5 cm from the deep margin and 0.2 cm from the superficial margin. Within the cystic parenchyma is a firm, poorly circumscribed, white-tan mass measuring 2.0 x 2.0 x 1.5 cm which comes to within 0.6 cm from the deep margin and 1.3 cm from the superficial margin. At least four scattered yellow-white nodules measuring from 0.5 cm to 0.8 cm in diameter are also seen within the cystic parenchyma located 0.3 cm from the deep margin and 1.5 cm from the superficial margin and at least 1.0 cm from the nass. The remainder of the specimen is composed of a moderate amount of breast tissue (60%) and a moderate amount of yellow fatty tissue (40%). Also received in the container is one irregular piece of soft, fibrofatty, yellow-red tissue measuring 4.0 x 3.0 x 1.0 cm. On cut surface, no discrete lesions or lymph nodes are identified. Representative sections are submitted in 26 cassettes labeled D1-D26. Please note: The specimen was placed in formalin at LEgEND: D1-D2 = Submucosal area D3-D4 = Mass with adjacent deep margin. D5-D7 = Remaining portion of mass D8 = Superficial margin closest to mass. D9-D10 = Nodule closest to mass with adjacent surrounding tissue and deep margin D11 = Remaining portion of nodule with adjacent surrounding tissue D12-D15 = Surrounding nodules in cystic parenchyma D16-D17 = Cystic parenchyma D18-D19 = Upper inner quadrant D20-D21 = Lower inner quadrant D22-D23 = Lower outer quadrant D24-D25 = Upper outer quadrant D26 = Fibrofatty tissue also received in the container.. Part E Is received unfixed in a container labeled with the patient's name and "Skin from mastectomy R breast". It consists of a strip of rubbery, tan-brown skin measuring 11.6 x 0.7 x 0.2 cm. Representative sections are submitted in one cassette labeled E1. Please note: The specimen was placed in formalin at. INTRAOPERATIVE CONSULTATION: AFS: Benign breast tissue and large ducts. No carcinoma seen. Page 2 of 5
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+SFS1, Bfs2: No carcinoma seen. CFS1, CFS2: No carcinoma seen. CFS3, CFs4: No carcinoma seen. Performed by:  Resident: Interpreted by: Attending: MICROSCOPIC DESCRIPTION: I. TYPE OF SPECIMEN:  Right total mastectomy with sentinel node dissection i. LOCATION OF THE TUmOR:  Central. III. TYPE OF NEOPLASM: Carcinoma, Invasive, Ductal - NOs (Nodule 1). Well Differentiated, Total score 4 (Tubule Score 1, Nuclear Grade Score 2, Mitotic Score 1) TUMOR SIZE: The tumor's greatest dimension 2.0 cm. Carcinoma, Invasive, Ductal - NOs (Nodule 2) Moderately Differentiated, Total score 7. (Tubule Score 3, Nuclear Grade Score 3, Mitotic Score 1) TUMOR SIZE:  The tumor's greatest dimension O.6 cm. Ductal carcinoma in situ, nuclear grade 3, widespread 30% QUANTITATION: Ductal carcinoma in situ is present in 15 of 26 slides of breast.. Intraductal solid subtype, cribriform, comedo, micropapillary/. V. VASCULAR SPACE INVASION: Present in lymphatics. VII. CALCIFICATiON: Present in both malignant and benign areas.. VIII NIPPLE: Ducts involved by DCIS. Ix. SKIN: Present, uninvolved by cancer. x. ADJACENT BREAST TISSUE: Cystic disease, proliferative with atypia.. XI. MARGINS: Tumor distance from closest margin DCI$- <0.1 cm fromm deep margin XII. AXILLARY LYMPH NODES: SentineI -2 XIIIi. POSITIVE LYMPH NODES: Sentinel - ITC only xv. PATHOLOGIC STAGING (pTNM) AJCC 7th Edition: Reflects staging only of the current specimen. Uitimate Staging responsibility rests with the primary physician. pT1c: Tumor more than 1.0 cm but not more than 2.0 cm in greatest dimension. pNo(ITC,i+): No regional lymph node metastasis on H & E histologically, (ie. Individual tumor cells seen, none greater than 0.2 mm, positive IHC. Page 3 of 5
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+COMMENT(S): Case shown at . This report has been reviewed electronically and signed on ' by. Interpreted by:  Attending: The dlagnosis was rendered by the attending pathologist. Receptor Expression Analysis Date Ordered: Status:Signed Out INTERPRETATION Test Performed on formalin fixed paraffin embedded section of: mastectomy The results are for invasive carcinoma #1 Specimen part:  Slide#: D3 Fixation: adequate. Results: This tumor is considered positive for estrogen receptor expression (1 % of the cells are positive). The. specimen was adequate for evaluation for ER as per ASCO/CAP guidelines 2010.  Approximately 75 % of the. carcinoma cell nuclei stain with an immunohistochemical stain utilizing an anti-estrogen receptor antibody ( ) with an average intermediate intensity. This tumor is considered positive for progesterone receptor expression ( 1 % of the cells are positive).  The specimen was adequate for evaluation for PR as per ASCO/CAP guidelines 2010.  Approximately 80 % of the. carcinoma cell nuclei stain with an immunohistochemical stain utilizing an anti-progesterone receptor antibody ) with an average strong intensity. Equivocal/indeterminate for HER2 expression. Her-2/neu over-expression has been evaluated, on a formalin fixed paraffin embedded section, using the (proprietary kit). Using the A$CO/CAP scoring criteria, the score is: 2. Invasive carcinoma #2: This tumor is considered positive for estrogen receptor expression (1 % of the cells are positive). The  specimen was adequate for evaluation for ER as per ASCO/CAP guidelines 2010. Approximately 100 % of the. carcinoma cell nuclei stain with an immunohistochemical stain utilizing an anti-estrogen receptor antibody SP1) with an average strong intensity. This tumor is considered positive for progesterone receptor expression ( 1 % of the cells are positive). The specimen was adequate for evaluation for PR as per ASCO/CAP guidelines 2010. Approximately 100 % of the carcinoma cell nuclei stain with an immunohistochemical stain utilizing an anti-progesterone receptor antibody. 1E2) with an average strong intensity.  Positive for HER2 overexpression. Her-2/neu over-expression has been evaluated, on formalin fixed paraffin. embedded sections, using the (proprietary kit). Using the ASCO/CAP scoring criteria, the score: 3. Page 4 of 5
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+This procedure/addenda has beon electronically reviowed and signed on by. Interpreted by: Attending: Note: Immunochemistry testing porformed at was developed and ils porformance characteristics determined by the . These lests were interpreted in conjunction with axternal positive and Intemal nogative controls, unloss otherwise noted, it has not been cleared or approved by ths US FDA. This test is used for dlinjl purposes only. It should not be regarded zs investigational or for rasearch. END OF REPORT Page 5 of 5
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+UUID: 8C845114-BBC6-45F2-9135-7E8298E24422 TCGA-C8-A26X-01A-PR Redacted IRB APPROVED Multi-media systems, Inc. Earm Revised Clinical Case Report /co-0-3 (For Collection of Cancerous Tissue) cavcnoms, infiItratry dtuct N0S 85003 Sif: busst Nos c5o.9 5/2t/Informed Consent Kml w5/xyu5/3/11 I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator Signature Date Clinical Information GENERAL INFORMATION Date of Birth (mm/dd/yyyy)  Height Marital Statusd Race Temperature  Single  Married Gender Weight  Divorced  Widow  Blood Pressure Heart Rate  Male Female HISTORY OF PRESENT ILLNESS Symptoms: Clinical Findings: iA msK nTho 7cgA hu aNFj kmy) nrte amj Performance Scale (Karnofsky Score):  100 AsymptomaticX 80-90 Symptomatic but Fully Ambulatory   60-70 Symptomatic, in bed less than 50% of day  40-50 Symptomatic, in bed more than 50% of day. but not bed ridden  20-30 Bed Ridden CURRENT MEDICATIONS Drug Dose Route Freguency Date (mm/dd/yyyy) To To To 1 To / To /
+
+--- Page 2 ---
+PAST MEDICAL HISTORY Diagnosis/Disease/Disorder/Injury Diagnosis Date Treatment Status OB/GYN HISTORY Menopausal Status Date of First Menses # of Pregnancies  Pre-menopausal fews od 0 2  Peri-Menopausal Da: Jast Menses # of Live Births Post-menopausa! 0 - Birth Control:  Condom  Oral Contraceptive IUD  Hormone Replacement Therapy:  Other: SOCIAL HISTORY Occupation: Environmental Hazards: Smoking History. Current Status TYPE  Packs/day Duration When Quit  yes NO (yrs) (yr) Alcohol Consumption Current Status TYPE Drinks/day Duration When Quit YES z0NO (yrs)  (yr) Drug Use Current Status Type  Frequency Duration When Quit  yes SNO (yrs) (yr) FAMILY MEDICAL HISTORY Relative Diagnosis Age of Diagnosis LAB DATA Test Test Result Date  Result Date HIV CEA  Negative  Positive: DNegative  Positive: Hep B  Positive: CA 15-3  Negative  Positive: PNegative Hep C CA 19-9  Negative  Positive: Negative  Positive: PSA   Negative  Positive: AFP Negative  Positive: Other: Other:  Negative  Positive:  Negative Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+DIAGNOSTIC STUDIES Study Results Date Ultrasound X-Ray cT Endoscopy MRI Biopsy  Daeast cansa CLINICAL DIAGNOSIS Preoperative Clinical Diagnosis Location of Suspected Involved Lymph Nodes. Location of Suspected Distant Metastasis  Clinical Staging Date of Diagnosis T A NAMO Stage: I A Treatment Information SURGICAL TREATMENT Procedure Date of Procedure Modihed Radieel  Matectomss Primary Tumop Organ Detailed Location Size Rigtf sseistTamoh 9p) pcR Cu Tok! cFucr cF/&r pt 1x/x cm Extension of Tumor Lymph Nodes Description  Location of Lymph Nodes # of Lymph Nodes Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Detailed Location Size Organ Surgical Staging Name. Stage: NEOADJUVENT THERAPY (Chemo, Radiation, Immuno, Hormonal, or Molecular) Drug/Treatment Dose Route Frequency Date (mm/dd/yy) To / To 1 To / To 1 To 3
+
+--- Page 4 ---
+Pathology Form Specimen Information. Collected by: Date: . Preserved by: .. Date: SPECIMEN TYPE (# of samples provided) Frozen Paraffin Block  Blood/Serum/Plasma Slide Diseased Normal Diseased  Normal Diseased Normal Diseased Normal 2 2 2 Z 2 2 Time to LN2 Time to Formalin Time to LN2 min 72 min min PATHOLOGICAL DESCRIPTION Primary Tumor Organ Size Extension of Tumor  Distance to NAT Riciti h&exsi iiznu? 1xAx cm Lpper cu ta quirazef 6 cm Lymph Nodes Location # Examined # Metastasized Distant Metastasis Organ Detailed Locationd Size Pathological Staging. pT 1 NA mo Stage: II Notes: BnergFncdeg in Nitreger 2 ex7KeHe5: (R M2 ) 4
+
+--- Page 5 ---
+Microscopic Description Histological Pattern Structural Pattern + Cell Distribution + x  Streaming  Diffuse  Storiform  Mosaic  Necrosis  Fibrosis X Palisading Lymphocytic Infiltration  Cystic Degeneration Vascular Invasion Clusterized  Bleeding  Myxoid Change Alveolar Formation Psammoma/Calcification Indilan File Cellular Differentiation Sarcomatous + Lymphomatous Squamous Adenomatous + x Round Cell  Large Cell  Squamoid Cell Glandular cell  Fibroblast Small Cell Spindle Cell  Cell Stratification  RS Cell/RS Like  Keratin Secretion Osteoblast Lipoblast Inflam. Cell  Desmosome Intracyt. Vacuole Myoblast Plasma Cell Pear!  Gland formation X Well Moderate   Poor Cellular Differentiation:  Nuclear Appearance 0 1 1I III Nuclear Atypia:  Aniso Nucleosis Hyperchromatism Y Nucleolar Prominent Y Multinucleated Giant Cell f Mitotic Activity Nuclear Grade: IHC Data Date Result Value  Marker ER Negative  Positive PR Negative  Positive  Negative  Positive Her-2/neu 8-Cell Marker Negative  Positive  T-Cell Marker  Negative  Positive Other: Negative  Positive Negative  Positive Other: Final Pathology Report Histological Diagnosis: /Grade: i Mtochalelg Xiftesertierjee Y i/ Poccrc7 re Xcs H (M, 1-) fY,(-)) 15Rerg7 rcek8(js'7iuR/,1eo3e7) Comments: 3 J Date   Pathologist ..Ptincipal Investigator 5
+
+--- Page 6 ---
+COnsolIdated Diagnostic patholOgy form* Microscopic Appearance:e Histological pattern: CELL DISTRIBUTION Diffuse + STRUCTURAL PATTERN Mosaic Streaming Necrosis  Storiform Lymphocytic Infiltration x Fibrosis Vascular Invasion Palisading Clusterized Cystic Degeneration Alveolar Formation X Bleeding Indian File Myxoid Change.  Psammoma/Caicification 2. Cellular features: Squamous + Adenomatous Squamoid Cell +  Sareomatous Glandular cell Lymphomatows Spindle Cell IX Round Cell Cell Stratification Large Cell Fibroblast  Keratin Small Cell Secretion x Osteoblast Desmosome RS CeIV/RS Like Intracyt. Vacuole Lipoblast Pear! Gland formation Inflam. Cell XMyoblast  Plasma Cell Otherwise Specified: 735% 9z50 Nees$ys 2.Cellular Differentiation: Well Moderately Poor Nuclear Atypia: Nuckar Appearance Aniso Nucieosis 9 Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity Nuclear Grade Histological Diagnosis: of(tnatsy rcta Ckle>/oao U 6~3 Comments:_M Ms y Clsksr/yan?hag(eki/P Date Director, Research Pathoiogy  PATHOLOGIST STAFF FOR RESEARCH USE ONLY).E *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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diff --git a/output/text/086daaa0-403e-4cfd-9daa-34d8019a7273.txt b/output/text/086daaa0-403e-4cfd-9daa-34d8019a7273.txt
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+
+--- Page 1 ---
+UUID:48DB8720-833D-467C-8BF2-95EF539B4D5E TCGA-CF-A1HS-01A-PR Redacted rorm kevised Clinical Case Report icd-0-3 Carcnoma, Squsmorg cilL,NcS Idka- demoid.Nos) 8070/3 Criteria Siter bInddw,NoS c47.9 14 Informed Consent I personally informed this patient that a specimen(s) would be collected to be used for research purposes.I reviewed the RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator. Signature Date Clinical Information ODATKSGENERALINFORMATIONCSAN Date of Birth (mm/dd/vyyy) Height  Marital Status Race Temperature Gender Weight Blood Pressure Heart Rate  Male Female 5 2 F0j 141 T8 YOGSPEMAHISTORYOEPRESENTILLNESS Symptoms: Hematr ; Weighf Loss Clinical Findings: Performance Scale (Karnofsky Score):  100 Asymptomatic   80-90 Symptomatic but Fully Ambulatory.  60-70 Symptomatic, in bed less than 50% of day. 40-50 Symptomatic, in bed more than 50% of day, but not bed ridden.   20-30 Bed Ridden RWNCURRENTMEDICATIONS..C Drug Dose Route Frequency Date (mm/dd/yyyy) To To To To / 1 1 To /
+
+--- Page 2 ---
+PAST MEDICAL HISTORY  Diagnosis/Disease/Disorder/Injury Diagnosis Date Treatment Status CPKAOBGYNHISTORYP  Menopausa! Status Date of First Menses # of Pregnancies  Pre-menopausal -okc4  Peri-Menopausa! Date of Last Menses # of Live Births Post-menopausa! Birth Control:  Condom  Oral Contraceptive A IUD  Hormone Replacement  Other: Therapy: WSOCIALHISTORYAX Occupation: Environmental Hazards: Smoking History Current Status TYPE  Packs/day  Duration When Quit YES NO (yrs) (yr) Alcohol Consumption Current Status TYPE Drinks/day. Duration When Quit  yes  NO (yrs) (yr) Drug Use Current Status TYPE Freguency  Duration When Quit  yes ZNO (yrs) (yr) MRWCAFAMILYMEDICALHISTORYEE Relative  Diagnosis Age of Diagnosis Test Result Date Test Result Date HIV p Negative  Positive: CEA   Negative  Positive: Hep B  Negative  Positive: CA 15-3   Negative  Positive: Hep C Negative  Positive: CA 19-9   Negative  Positive: AFP  Negative  Positive: PSA  Negative  Positive: Other: Other:  Negative  Positive:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+ADIAGNOSTICSTUDIESROC Study Results Date Ultrasound  A tonwy w the U.bladden: X-Ray  CT Endoscopy MRI Biopsy PASNACLINICALDIAGNOSISOAR. Preoperative Clinical Diagnosise Location of Suspected Involved Lymph Nodes Location of Suspected Distant Metastasis. Clinical Staging Date of Diagnosis T3 No Mo Stage: 1 Treatment Information SEAHESURGICALTREATMENTENOAAE Procedure Date of Procedure. U. Bledder Reseeti'm Primary Tumor Organ Detailed Location Size Bletdefer lumtR QprinerQ 5x 4x2 cm Extension of Tumor. Lymph Nodes Description Location of Lymph Nodes. # of Lymph Nodes. Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Organ Detailed Location Size Surgical Staging T3 No mo Stage: 7U Dose Route Frequency Drug/Treatment Date (mm/dd/yyy) To / To / / To To / To 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by Date Preserved by: Date: SPECIMENTYPE #of samples provided  Blood/Serum/Plasma Slide Frozen Paraffin Block Diseased Normal Diseased Normal Diseased Normal Diseased Normal 2 4 Time to LN2 Time to Formalin Time to LN2 min 12 min min EAA PATHOLOGICALDESCRIPTIONE A Primary Tumor Organ Size Extension of Tumor Distance to NAT 5 hladeden 3 x4 x2 cm cm Lymph Nodes Location. # Examined # Metastasized Distant Metastasis  Organ Detailed Location Size Pathological Staging Mo pT 3 No Stage: ! Notes: 4
+
+--- Page 5 ---
+Microscopic Description aHistologicalPatternawan Cell Distribution + Structural Pattern + Diffuse  Streaming Mosaic  Storiform  Necrosis Fibrosis Lymphocytic Infiltration  Palisading Vascular Invasion  Cystic Degeneration Clusterized Bleeding  Alveolar Formation  Myxoid Change  Indian File  Psammoma/Calcification a.CelluaDifferentiationwa Squamous +- Adenomatous +-  Sarcomatous +-  Lymphomatous + Squamoid Cell X Glandular cell  Round Cell  Large Cell Spindle Cell Cell Stratification Fibroblast Small Cell  Keratin Secretion  Osteoblast  RS Cell/RS Like  Desmosome Intracyt. Vacuole Lipoblast Inflam. Cell  Pearl Gland formation Myoblast  Plasma Cell Cellular Differentiation: Well I9 Moderate  Poor Bhxa NuclearAppearancerw Nuclear Atypia: 0 I II III Aniso Nucleosis Hyperchromatism Nucleolar Prominent  Multinucleated Giant Cell Mitotic Activity Nuclear Grade: Marker Result Value Date ER  Negative Positive PR  Negative  Positive Her-2/neu  Negative  Positive B-Cell Marker  Negative_ Positive T-Cell Marker  Negative  Positive Other:  Negative   Positive Other:  Negative  Positive Final Pathology Report 8070|3 E0j o(er mv` crrcirum) cf The folecleleR Histological Diagnosis: Grade: Comments:  Principal Investigator Pathologist Date 5
+
+--- Page 6 ---
+COnsOLIdaTeD DIagnOstIc PathoLOgy fOrm* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION Diffuse STRUCTURAL PATTERN Mosaic XStreaming Necrosis  Storiform Lymphocytic Infiltration Fibrosis Vascular Invasion x Palisading Clusterized X Cystic Degeneration Alveolar Formation X Bleeding Indian File Myxoid Change 2. Cellular features. Psammoma/Calcification Squamous Adenomatous +  Sarcoratous  Squamoid Cell x Lymphomatous Glandular cell Round Cell Spindle Cell Large Cell Cell Stratification Fibroblast Keratin Small Cell Secretion Osteoblast  RS Cell/RS Like Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell Pear! X Gland formation Myoblast  Plasma Cell Otherwise Specified: D1 75 D275%  d775%. 7s% 2.Cellular Differentiation: R0~TY Well Moderately Poo Nuclear Atypia: Nucitar Appearance Aniso Nucleosis Hyperchromatism X Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity Nuckear Grade X 8074/3 Histological Diagnosis: SQn ohsus Ce/ Care>jro. Comments: Date Director, Research Pathology PATHOLOGIST STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR ANDE
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diff --git a/output/text/088f6a94-d143-4a5b-b27b-f7561a4a9566.txt b/output/text/088f6a94-d143-4a5b-b27b-f7561a4a9566.txt
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+
+--- Page 1 ---
+TCGA-D5-6531 page 1 / 1 Examination: Histopathological examination. Material: 1. Partial resection of organ - colon and caecum. Physician in charge:. Material collected on: Material received on: Expected time of examination. Clinical diagnosis: Cancer of the hepatic flexure Examination performed on: Macroscopic description: 25 cm length of the large intestine with periintestinal fat tissue of 25 x 8 x 2cm. Omentum sized 12 x 10 cm. Edge-thickened ulceration sized 4 x 3 cm in the mucosa. The lesion covers 100% of the intestine circumference, located 12 cm from the proximal cut end and 8 cm from the distal cut end. The lesion macroscopically infiltrates the periintestinal tissue.. Microscopic description: Adenocarcinoma tubulare (G2). Infiltratio carcinomatosa telae adiposae pericolicae. Intestine ends clear of neoplastic lesions. Lymphonodulitis reactiva (No IV). Histopathological diagnosis: Adenocarcinoma tubulare coli. Tubular adenocarcinoma of the colone. (G2; Dukes B; Astler-Coller B2; pT3; pN0).
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index 0000000000000000000000000000000000000000..5cb7302a3e692c9472d0fa1055424696e82f70d6
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+
+--- Page 1 ---
+TCD-0-3 UUID:093D8D72-8D18-4C23-A132-D0DCBB05DE26 TCGA-OR-A5LH-01A-PR Redacted Tumor, Advevad CortcaI of anpniwsJuncer tin beh ayss 83703 Site: Adrenol Glard Cor ter C 74 d JpJ q/b/13 Procedure: adrenalectomy Gross description: 11 x 6 x 4.5cm, 290g Diagnosis: adrenocortical carcinoma, 1 per 10 hpf Reference Pathology: none. Phuss-if em Psosua- nL cu Nyust^mn pxM. Msy nst ship jf nrf muhiqsut
+
+--- Page 2 ---
+Patient # from Tissue Source Site Date of report. Date of Surgery/specimen collection Site (confirmed to be adrenal) with laterality indicated Tumor size(s) 11x6x4.5cm Histologic diagnosise ACC Lymph Node Status x Pathologic information Weiss score
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diff --git a/output/text/0892bdf7-125a-41db-8de9-6b69cd044c5b.txt b/output/text/0892bdf7-125a-41db-8de9-6b69cd044c5b.txt
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index 0000000000000000000000000000000000000000..0ec13aff08b48b2d98a63bcd682e37190b83d0c2
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+
+--- Page 1 ---
+Surgical Pathology Report Name: Case #: DOB: Collected: Gender: Received: MRN: Reported: Location: Copy To: Physician: Pathologic Interpretation: A.  Right HS1 Axilla 1 count . FS: - No carcinoma seen on routinely stained section. Immunohistochemistry for keratin to follow. B. Right HS1 axilla 1 count FS: 1cs-0-3 - No malignancy seen in one lymph node (0/1). Cernomn, vifiltmating lobulv, Nos 85$0/3 C. Right HS1 axilla 1 count :s: Pash Sit. bust lowwontw gusirnt C5O. - No malignancy seen in six lymph nodes (0/6). CQcF Iih: Braot nos c50.9 D.  Right HS 1 axilla 1 count - Fibroadipose tissue, no specific pathologic change. E.  Right breast (1 suture-superior; 2 sutures-medial): - Tnvasive lobular carcinoma, well differentiated, Nottingham grade 1 (3+1+1=5). 1.1 cm in greatest linear dimension. - Resection margins free of tumor. - Lymphovascular invasion not identified. -Biopsy site present. Predictive markers performed on previous biopsy ' ) were positive for ER and PR and negative for Her-2 and E-cadherin by Immunohistochemistry. - Please see tumor summary. F.Left breast (1suture-superior; 2 sutures-medial): - Fibrocystic changes including adenosis, stromal fibrosis, usual ductal hyperplasia find microcysts with focal columnar cell change. - Microscopic Intraductal papilloma, 1.5 mm. Right axillary dissection: UUID:0046FACA-9E90-4BA9-B216-258A2A7A2EC6 . No malignancy seen in seventeen lymph nodes (0/17). TCGA-EW-A132-01A-PR Redacted H. Right apical axilla: - No malignancy seen in one lymph node (0/1). INVASIVE CARCINOMA OF THE BREAST Specimen Type:e - Total breast Procedure - Total mastectomy Lymph Node Sampling. - Sentinel lymph node, axillary dissection Specimen Integrity - Single intact specimen Specimen Laterality: - Right Tumor Site: Invasive Carcinoma - Lower outer quadrant Tumor slze: Size of Largest Invasive Carcinoma - Greatest dimension of largest focus of invasion over 0.1 cm: 1.5 cm *Additional dimensions: 1.5 x 1.5 cm Tumor Focality - Single focus of invasive carcinoma Macroscopic and Microscopic Extent of Tumor - Skin is not present Skeletal Muscle:d - No skeletal muscle present Lobular Carcinoma In Situ (LCIS)
+
+--- Page 2 ---
+SURGICAL PATHOL Report . - Present Histologic Type of Invasive Carcinoma - Invasive lobular carcinoma Histologic Grade: Nottingham Histologic Score - Score 3: <10% of tumor area forming glandular/tubular structures Nuclear Pleomorphism - Score 1: Nuclei small with litle increase in size in comparison with normal breast epithelial cells, regular outlines, niform  nuclear chromatin, little variation in size. Mitotlc Count - Score 1 Overall Grade - Grade 1: scores of 3, 4 or 5 Margins - Margins uninvolved by invasive carcinoma; Distance from closest margin: 1.5 mm (medial) Treatment Effect: Response to Presurgical In the breast: No known presurgical therapy In the lymph nodes: No known presurgical therapy. Lymph-Vascular Invasion: Not identified. Dermal Lymph-Vascular invasion: - Not identified Lymph Nodes Number of sentinel lymph nodes examined: 13 Total number of lymph nodes examined (sentinel and nonsentinel): 21 Number of lymph nodes with macrometastases (>0.2 cm) 0. Number of lymph nodes with micrometastases: 0 Number of lymph nodes with isolated tumor cells: 0 Size of largest metastatic deposit: 0 Extranodal Extension: -Not identified Method of Evaluation of Sentinel Lymph nodes - H&E, one level - immunohistochemistry to follow Pathologic Staging (pTNM) TNM Descriptors (multiple foci of invasive carcinoma). Primary Tumor (Invasive Carcinoma) (pT) pT1c Regional Lymph Nodes (pN) pNO Distant Metastasis Not applicable Ancillary Studies - Performed on another specimen Specify specimen: Results: Immunoreactive tumor cells present (>1%) Progesterone Receptor: - Performed on another specimen Specimen: Results: immunoreactive tumor cells present (>1%) Immunoperoxidase Studies - Performed on another specimen Specify specimen: Results: Negative (0) NOTE: Some immunohistochemical antibories ars analyte specific reagents (ASRs) valldaied by our iaboratory. These ASRs are clinically usgul indicorors thol do nos require FDA approval. Thtse clones as JD5ER. PgR 636-PR, A485-HER2, H-1J-EGFR. Ail immunohissochenical stains are used with formalin or molecular fixed. poraffin embedded tissue. Dereclion is by Envision Method. The r sults are reod by a  pathologist as positive or neguive  Page 2 of 4
+
+--- Page 3 ---
+SURGICAL PATHOL Report As the attending pathologist, I attest that I: (i) Examined the relevont preparation(s). for the specimen(s): and (ii) Rendered the diagnosis(es). ***Electronically Signed Out By*** Intraoperative Consultation A. Right HS1 Axilla 1 count. . - FS: Microscopic focus of metastatic lobular carcinoma in tymph node.. B. Right HS1 axilla 1 count FS: No conciusive evidence of carcinoma, wait for permanent. C. Right HS1 axilla 1 count FS: No conclusive evidence of carcinoma, wait for permanent.. Clinical History: Biopsy-proven carcinoma right breast, invasive carcinoma with lobular pattem and associated ductal carcinoma in sit* Please evaluate sentinel nodes and margins. if sentinel nodes are H&E (negative), do IHC.. Operation Performed Right total mastectomy with sentinel lymph node biopsy, possible axillary node dissection, plus ieft total mastectomy Pre Operative Diagnosis: Carcinoma right breast, G1 Specimen(s) Received: A: Right HS1 Axilla 1 count - FS B: Right HS1 axilla 1 count FS C: Right HS1 axilla 1 count 1 FS D: Right HS 1 axilla 1 count E: Right breast (1 suture-superior; 2 sutures-medial). F: Left breast (1suture-superior; 2 sutures-medial). G: Right axillary dissection H: Right apical axilla Gross Description: A.  Received fresh is a segment of tan yellow fibroadipose tissue measuring 4.5 x 3 x 1 cm. Examination of the $pecimen  includes multiple lymph nodes. Cassettes are submitted as follows:. 1&2 One lymph node, bisected per cassette submitted for frozen 3 Four possible lymph nodes. 8. Received fresh is a segment of tan yellow fibroadipose tissue measuring 1.2 x 0.8 x 0.6 cm. The specimen is bisected and submitted in one cassette for frozen. C. Received fresh is a segment of tan yellow fibroadipose tissue measuring 6 x 4 x 1 cm. Examination of the specimen reveals four possible lymph nodes. Cassettes are submitted as follows:. 1&2 Largest lymph node bisected, submitted in toto in two cassettes for frozen. 3 One lymph node in toto submitted for frozen 4&5 Two possible lymph nodes submitted in toto D. Received in formalin is a segment of tan yellow fibroadipose tissue measuring 5.5 x 4 x 1 cm. No lymph nodes are. identified. Representative sections of fibroadipose tissue submitted in one cassette. E.  Received in formalin is a 1000 grams, 20 x 18.5 x 4 cm right mastectomy specimen with an ellipse of skin that measures Page 3 of 4
+
+--- Page 4 ---
+SURGICAL PATHOL Report 17 x 9 cm. The nipple-areolar compiex measures 5.5 cm and it appears unremarkable. The specimen is oriqnted with one. stitch-superior, two stitches-mediai. Resection margins are inked black. On serial section, there is a tan-white indurated ill- defined lesion with infiltrative borders present at the lower outer quadrant, at approximately 5 o'clock positiqn. This lesion measures 1.5 x 1.5 x 1 cm. It is located 0.2 cm from the medial margin (ciosest), 2.5 cm deep margin, 3 cm from inferior margin, 8 cm from superior margin, 15 cm from lateral margin and 6 cm from nipple. A metal clip is identifieq within the lesion. No other leslons are grossly identified. No lymph nodes are present within the main specimen. Cassettes are. submitted as follows:  Mass in relation to medial margin. 2 Deep margin 3 Superior margin 4 Inferior margin 5 Lateral margin 6 Nipple 7 Skin closest to lesion 8-10 Remainder of the lesion, submitted in toto F. Received in formalin is an 897-gm left mastectomy specimen measuring 18 x 16 x 4 cm. An attached ellipst of skin is. present. The nipple areolar complex is unremarkable. On serial sections, no lesions or suspicious areas are grossly. identified. The breast parenchyma has a fat to stroma ratio of 70:30. Representative sections are submitted as follows: 1&2 Upper outer quadrant 3&4 Upper lower quadrant. 5&6 Upper inner quadrant 7&8 Lower inner quadrant 9  Nipple G.  Received in formalin is a segment of tan yellow fibroadipose tissue measuring 8 x 4 x 4 cm. Examination of the specimen reveals multiple possible lymph nodes. Cassettes are submitted as follows: 1-6 One lymph node bisected per cassette 7 Two lymph nodes in toto. 8-10 Three lymph nodes in toto per cassette. H.  Received in formalin are three fragments of tan yellow to gray fibroadlpose tissue measuring in aggregate. 2|5 x 1 x 0.6 cm. The specimen is submitted in toto in one cassette. Page 4 of 4
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new file mode 100644
index 0000000000000000000000000000000000000000..d02277aab18add34a688a87b4dcd1441cbad31ec
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+
+--- Page 1 ---
+FD45A76-33F6-47BA-A9EC-0AF6A7E28B5E U-01A-PR Redacted SURGICAL PATHOLOGY REPORT Patient Namet Accession #: Med. Rec.# Visit #: Service Date: DOB: ex: Male Received: Soc. Sec. #: Location Client: Physician(s): FInal Pathologic Diagnosis Kidney, right, partial nephrectomy: Papillary renal cell carcinoma, 5.8 cm; see comment. IcD.d3 Comment: Cerenmy yayaellare Kidney Tumor Synoptic Comment. - Histologic type: Papillary renal cell carcinoma, Type 1. NnsI ceQl. 8360/3 - Grade: Fuhrman grading for RcC: grade 2. - Tumor size: 5.8 x 4.5 x 3.3 cm.. Site R Kiolney NoS C64.9 - Site within kidney: Mid to inferior pole of right kidney. - Renal pelvis: NA. VJ3l3J!4 - Ureter: NA. - Renal sinus: NA. - Hilar renai veins: NA. - Intrarenal veins and Iymphatics: No tumor. - Adrenai giand: NA - Capsule/perirenal fat: No tumor.. - Lymph node status: Not surgically sampled. - Resection margins: Negative. - Ureter: NA. - Renal vein: NA. - Soft tissue: Negative, 0.6 cm to perirenal fat margin.. - Renal parenchyma: Negative but close, less than 0.1 cm to margin.. - Proximity to nearest margin: Less than 0.1 cm. - AJCC Stage:pT1bNXMX. Specimen(s) Received A:Kidney, Partial Nephrectomy (fresh). Intraoperative Diagnosis Page 1 of 2
+
+--- Page 2 ---
+Right kidney, gross evaluation: Tumor approaches the surgical margin by <1 mm. (Dr. Clinical History The patient is a . year-old male who was discovered to have an incidental finding of a 4.6 cm enhancing renal mass on the anterior aspect of the mid to inferior pole of the right kidney. The patient undergoes an open partial right nephrectomy. Gross Descriptiond The specimen is received in formalin in one part, labeled with the patient's name, medical record number and "right partial nephrectomy," and consists of an unoriented ovoid apparent renal tissue that is firm, and a soft apparent fat tissue. The tota! specimen measures 9.2 x 4.6 x 4.5 cm. The ovoid renal tissue measures 6.2 x 4.5 x 3.8 cm and the fat tissue measures 9.2 x 3.5 x 0.5 cm. The specimen was received with all margins inked black and has been serially sectioned. The renal mass abuts the surgical margin and occupies approximately 90% of the renal tissue. The mass is ovoid and soft, tan-white, and measures 5.8 x 4.5 x 3.3 cm. There is a red-brown region of apparent necrosis/hemorrhage, measuring 3.1 x 2.7 x 2.5 cm, within the renal mass. A thin rim of apparent renal parenchyma surrounds the mass, with the thickest depth measuring 0.9 cm. The perirenal fat Is soft and unremarkable. Representative sections are submitted as follows: Cassette A1: Renal mass with resection margin, two sections. Cassette A2: Rena! mass showing relationship to inked perirenal fat, two sections. Cassette A3: Renal mass showing relationship to inked perirenal fat, one section. Cassette A4: Renal mass/necrosis, one section. Cassette A5: Apparent normal renal. parenchyma, one section. Diagnosis based on gross and microscopic examinations. Final diagnosis made by attending pathologist following review of all pathology slides. YPathology Resident. Pathologiste Electronically signed out on. 14114 Page 2 of 2
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+
+--- Page 1 ---
+UUID:CFC9112B-5398-4692-AD18-4055BC8EF49D TCGA-NP-A5H5-01A-PR Redacted Results GROSS AND MICROSCOPIC SURGICAL PANEL Specimen Information Collection Date and Time Component Results SURGICALPANEL Final Report DIAGNOSIS KIDNEY, RIGHT, LAPARSCOPIC NEPHRECTOMY: 1. Renal cell carcinoma, chromophobe type, characterized by:. a. Tumor size: 4.5 x 4 x 2.4 cm b. Tumor location, upper pole of kidney c. Tumor grade: Grade 2 (of 4, Furman) d. Tumor extent: Tumor confined to kidney, abuts the overlying renal capsule but does not extend beyond e. Additional findings: Coagulative tumor necrosis - negative, sarcomatoid differentiation - negative 2. Margins of resection are negative for malignancy 3. Background renal parenchyma shows no significant abnormalities 4. See staging parameters  KIDNEY STAGING PARAMETERS*** Case number: atient name: Fina! TNM: pT1bNXM0 stage: I tcD-6-3 MACROSCOPIC PROCEDURE Radical nephrectomy arcinona,nenal eel! SPECIMEN LATERALITY Chgmophobe type 83i7|3 Right TUMOR SITE Site Upper pole TUMOR SIZE 4.5 X 4 X 2.4 cm TUMOR FOCALITY  Unifocal MACROSCOPIC EXTENT OF TUMOR Tumor limited to kidney MICROSCOPIC HISTOLOGIC TYPE Chromophobe renal cell carcinoma TUMOR NECROSIS Not identified HISTOLOGICAL GRADE G2: Nuclei slightly irregular, approximately 15 um; nucleoli evident MICROSCOPIC EXTENT OF TUMOR Tumor limited to kidney LYMPHATIC VASCULAR INVASION Not identified
+
+--- Page 2 ---
+MARGINS Uninvolved by carcinoma NON-NEOPLASTIC KIDNEY PATHOLOGY Not identified PATHOLOGIC STAGING EXTENT OF INVASION pT1b. (Tumor more than 4 cm but not more than 7 cm in greatest dimension limited to the kidney) REGIONAL LYMPH NODES pNX. (Regional lymph nodes cannot be assessed) DISTANT METASTASIS pM0. (No distant metastasis) PATHOLOGIC STAGE Summary Final TNM: pT1bNXM0 I stage: I : The pathologic stage presumes no lymph node metastasis. ** The pathologic stage presumes no distant metastasis.. Attending Pathologist: CLINICAL INFORMATION -year-old female patient with a 4 cm right upper pole renal mass. discovered incidentally on imaging.. SPECIMEN/GROSS DESCRIPTION A) SOURCE: Right kidney The specimen is received labeled and is designated "right kidney" and consists of a 333 gram right radical nephrectomy with associated adipose tissue measuring 12 x 16.5 x 4.5 cm. The vascular and urethral margins are removed and submitted en face. The kidney is bivalved revealing a 10 x 8 x 4 cm kidney containing a 4.5 x 4 x 2.4 cm yellow-red hemorrhagic-appearing lesion located within the upper pole. There is no tumor identified in the renal vein. The tumor appears to abut the renal capsule; however, no direct extension into the associated adipose tissue is grossly identified. Grossly this lesion comes to within 1.5 cm of the hilum. The remainder of the renal cortex has a pale tan-red appearance with an average cortical thickness of 0.6 cm. No other discrete mass lesions are identified. A portion of the tumor is taken for possible cytogenetic study and representative tissues are frozen for possible ancillary study. No lymph nodes are present within the associated adipose tissue and no adrenal gland is identified. A photo was taken of the specimen. The specimen is sampled in 11 cassettes as follows: 1. Ureteral margin, en face Vascular margins, en face 2 3-5. Representative sections of tumor 6-7. Tumor and adjacent normal parenchyma 8-9. Uninvolved renal parenchyma 10-11. Representative random hilar fat Gross dictation by: MICROSCOPIC The microscopic appearance substantiates the diagnosis. Dictation by. transcribed by Mireto. cARemop repancy m
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diff --git a/output/text/08d191f8-a703-49a3-b26e-482ab77d816f.txt b/output/text/08d191f8-a703-49a3-b26e-482ab77d816f.txt
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index 0000000000000000000000000000000000000000..d30dae1ef51ec69566921e7eafebc8bc7ebfd2ae
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+--- Page 1 ---
+UUID:CA1E5192-ABB0-45E6-8547-2BA2B035238C0 TCGA-C8-A8HR-01A-PR Redacted Clinical Case Report (For Collection of Cancerous Tissue) t0D-O 3 Careentms,Seular iyittialing NS 8 852qfB St %uastNOS c So.9 Informed Consent. f I1126|13 I personally informed this patient that a specimen(s) would be collected to be used for research purposes.I reviewed the.  RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator. Signature Date Clinical Information GENERAL INFORMATION Date of Birth (mm/dd/yyyy) Height. Marital Status Race Temperatured Single Married VIETNAMESE Gender Weight  Divorced  Widow  Blood Pressure Heart Rate  Male Female HISTORY OF PRESENT ILLNESS Chief Complaints: Nippte. retractin j Pe'n m the riczhs hreast Symptoms: Clinical Findings:. Performance Scale (Karnofsky Score):.  100 Asymptomatic80-90 Symptomatic but Fully Ambulatory  60-70 Symptomatic, in bed less than 50% of day.  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden  20-30 Bed Ridden CURRENT MEDICATIONS Drug Dose Route Frequency Date (mm/dd/yyyy) To / To 1 1 1 To 1 / To 1 ". / To
+
+--- Page 2 ---
+PAST MEDICAL HISTORY  Diagnosis/Disease/Disorder/Injury Diagnosis Date Treatment Status OB/GYN HISTORY Menopausal Status Date of First Menses # of Pregnancies  Pre-menopausal 02  Peri-Menopausa! vate or Last Menses # of Live Blrths  Post-menopausa! 0 2 Birth Control:  Condom  Oral Contraceptive #lUD  Hormone Replacement Therapy:  Other: SOCIAL HISTORY . Occupation: Environmental Hazards: Smoking History Current Status TYPE Packs/day Duration When Quit D YES  gNO (yrs) (vr Alcohol Consumption Current Status TYPE Drinks/day Duration When Quit o yes NO (yrs) (y) Drug Use Current Status Type Frequency Duratlon When Quit  YES  SNO (yrs) y FAMILY MEDICAL HISTORY Relative  Diagnosis Age of Diagnosis H.......: LAB DATA Test Result Date Test Result Date HIV  Negative  Positive: CEA  Negative  Positive: Hep B  Negative  Positive: CA 15-3  Negative  Positive: Hep C -PNegative  Positive: CA 19-9  Negative  Positive: AFP  Negative  Positive: PSA  Negative  Positive: Other: Other:  Negative  Positive:  Negative  Positive:  B/T Cell Markers: 2
+
+--- Page 3 ---
+DIAGNOSTIC STUDIES Study Results Date Ultrasound X-Ray CT Endoscopy MRI Biopsy A CV cinwn6 CLINICAL DIAGNOSIS Preoperative Clinical Diagnosis K. Broaet couseee Location of Suspected Involved Lymph Nodes Location of Suspected Distant Metastasis  Clinical Staging Date of Diagnosis. T3 N2 MO Stage:IA- Treatment Information SURGICAL TREATMENT Procedure Date of Procedure  Primary Tumor Organ Detailed Location Size Daers! Lanek AO hzeeg2 l9 x8 x 3 cm Extenslon of Tumor Lymph Nodes Description Location of Lymph Nodes # of Lymph Nodes Palpable, Non-Dissected Lymph Nodes. Dissected Lymph Nodes Distant Metastasis Organ Detailed Location Slze Surgical Staging t3 n2 Ma Stage:  NEOADJUVENT THERAPY (Chemo, Radiation, Immuno, Hormonal, or Molecular) Drug/Treatment Dose Route Frequency Date (mm/dd/yyyy) To 1 1 To 1 To 1 / To To 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by: - Date , Time: Preserved by: -- Date: 'ime: SPECIMEN TYPE (# of samples provided) Frozen Paraffin Block  Blood/Serum/Plasma Slide Diseased Norma! Diseased  Normal Diseased Normal Diseased Normal 2 4 2 2 Time to LN2 Time to Formalin Time to LN2 min min min PATHOLOGICAL DESCRIPTION Primary Tumor Organ Size Extension of Tumor Distance to NAT BAeasT Hner Fx8 x3 cm Mate SFeas cm Lymph Nodes Location # Examined # Metastaslzed Distant Metastasis Organ Detailed Location Size Pathological Staging pT 3 N 2 M Stage: U Notes: f08 T'vee 5 NcgTjcee 3 4
+
+--- Page 5 ---
+Consolidated Pathology Diagnosis. Cell Distribution + Strctxral Pataarn Difuse 1 Streaming +  Mosaic Storform Necrosis Filbrosis Lym phocytic Infikrationd Palisedino Vascutar Invasion Cstic Deoeneration Custerized Bleeding Alveotar Formation M xoid Change Indian Fhe Seusnenoues +- Aderonatouis + Shrcomatous + - L mphomatous Seuarnoid Cell Gtanduiar cell + Round Cell Lame Ce Spindle Ce Cell Stratunkation Fiorobiast Srrall Cen Keratin  Sexretion Osteobiast rs Cears Likee Desxngsome. Intract. Vacuole ILioobiast Infem. Col Pear! Gland formation x Myobtest Plasna Cel Celluiar Differentiation:  Wel  Moderate rPoor Nacsaer At ypia: 0 1 Aniso Nucleosis m Hyperchromatism Nucseolar Prominent Mutinucieeted Giant Celd Milotic Activity Nuciear Grade: d Fina! Pathology Repor? Histological Diagnosis: /opiltsetsr/ Lohss luCaemis Pna Grade: Cormmente: k1,-nrr : Can:roong totCtAze1 ts LN Date Director, Research Pacnoiogy lw 118113 Crilcria INTEGRATED REPORT OF FINDINGS BY COLLASORATORS AND Cingnosis uis reuana y nSite Dis pany MgHto Cush nou  ISOUALNE
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diff --git a/output/text/092a188c-c3d2-4ec1-a22e-ffde60a8ec35.txt b/output/text/092a188c-c3d2-4ec1-a22e-ffde60a8ec35.txt
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+
+--- Page 1 ---
+page 1 / 1 Department of Cancer Pathology TCGA-D5-6537 Examination: Histopathological examination re Material: Partial organ resection -- transverse colon. Physician in charge:. Material collected on:. Material received on. Expected time of examination! Clinical diagnosis: transverse colon with tumour. Examination performed on:. Macroscopic description 14 cm length of the large intestine with a piece of mesocolon sized 12 x 5 x 2 cm and a fragment of omentum sized 22 x11x1 cm. Calliflower-shaped tumour sized 3 x 3.5 cm in the intestina! mucosa. The lesion surrounds 100% of the circumference Iocated 3 cm from the one cut line, and 3 cm from the opposite one. Minimal side margin is 1.8 cm. A polyp 0.5 cm j diameter found off the tumour. Microscopic description: Adenocarcinoma tubulare partim mucinosum (G3). Infiltratio carcinomatosa tunicae muscularis priopriae et telae adiposae pericolicae. Excision lines free of neoplastic lesions. Outside the tumour: Adenoma tubulare cum dysplasia gradus levioris. Omentum sine metastasibus. Metastases carcinomatosae in lymphonodo (No I/XI).. Histopathological diagnosis:. Adenocarcinoma tubulare mucinosum partim coli. Metastases carcinomatosae in lymphonodo (No I/xll). Tubular and partially mucinous adenocarcinoma of the colon. (G3, Duke C, Astler - Coller C2, pT3, pNla).. CONTACT YOUR DOCTOR WITH THIS REPORT!
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diff --git a/output/text/0933d1ac-078d-4666-9c79-fbc2f00d710a.txt b/output/text/0933d1ac-078d-4666-9c79-fbc2f00d710a.txt
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+
+--- Page 1 ---
+(V-u-.) Lanoinr 1f19/n hv c5e.9 Situ: Bust, NoS Diagnosis: 3. Left-sided breast resection material with a 1.8 cm moderately differentiated tubulolobular breast carcinoma with an equally sized component of intraductal tumor propagation of the lobular tumor component and a minimum margin of 5 mm at 12 o'clock and over 10 mm at. 3 o'clock and about 1 mm at 6 o'clock (well over 10 mm at 9 o'clock) without any evidence of invasion of the lymph vessels. Tumor classification: M-8500/3, G 2, pT1c, pL0, pSN0 (0/2), pMx, stage I. R 0. UUID:C616E97C-8352-4FED-9E83-558318216F86 TCGA-A8-A09T-01A-PR Redacted
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diff --git a/output/text/0935bed0-b479-4927-ba9e-7e13ca1d3e21.txt b/output/text/0935bed0-b479-4927-ba9e-7e13ca1d3e21.txt
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index 0000000000000000000000000000000000000000..4c909b246bf5f934061e85daf1371280319609d7
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+
+--- Page 1 ---
+UUID:2E442714-A485-48C1-80FD-9418A8D94D9C TCGA-DM-A0XF-01A-PR Redacted TSS Patient ID: Sample Procurement: Date: Gender: I Date of Birth: Vital Status: Deceased Date of Death: Race: White Ethnicity: Not Hispanic or Latino  Specific Ethnicity: Histologic Subtype: Colon adenocarcinoma Date of Initial Path Dx: ' Primary Site: Colons Anatomic Site: Sigmoid Colon T Stage: 3 N Stage: 1 M Stage: 1 Overall Stage: IV Date of Normal Procurement: 1cd-0 -3 Qdencascinoma.Nos 814o13 Site: Sigmoid CooN C 19.7
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index 0000000000000000000000000000000000000000..5cf47f3f3a1c46d13a56a15488b2ec14c862e2f3
--- /dev/null
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+
+--- Page 1 ---
+Diagnosis: Colon resectate 18 cm in length with inclusion of a 4 cm longitudinally extended, wide, ulcerated, moderately differentiated adenocarcinoma of colorectal type with wide infiltration of the pericolic fatty tissue, circumscribed penetration of the overlying serosa and evidence of lymphangiosis carcinomatosis. Tumor-free regional lymph nodes. Tumor- free colon resection margins. Tumor stage: pT4 pN0 (0/36) pMX, G2, L1 V0
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diff --git a/output/text/09551665-3112-412e-9eef-4a845d2af6e4.txt b/output/text/09551665-3112-412e-9eef-4a845d2af6e4.txt
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index 0000000000000000000000000000000000000000..cbd4499e864fcfc35a9bc5eb9bd426aeecfd2780
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+--- Page 1 ---
+UUID: 5C0FC1D3-5FFA-4B43-9C33-32E0E7D5EFCE IcD o -3 TCGA-UW-A7GC-01A-PR Redacted arcinono renol cell cuomephole 8317/3 R Yidney NoS Surgical Pathology Report C649 Diagnosis: J 9/241l3 A: Kidney, right, radical nephrectomy Tumor histologic type: Renal cell carcinoma, chromophobe type, eosinophilic variant; see comment Sarcomatoid features: Not identified Histologic grade: grade 3 of 4 (Fuhrman classification) Tumor size: 4.5 x 4.2 x 3.5 cm (gross measurement) Tumor focality: Unifocal Extent of tumor invasion (if present specify if macroscopic or microscopic) : Capsular invasion/perirenal adipose tissue: Negative for malignancy, but close; tumor is less than 1 mm from the capsular surface Gerota' s fascia: Not involved Renal sinus: Not involved Major veins (renal vein or segmental branches, Ivc): Not involved Ureter: Not involved. Venous (large vessel): Not identified Lymphatic (small vessel): Not identified Surgical margins: Gerota' s fascia (nephrectomy): Negative for malignancy Renal vein (nephrectomy): Negative for malignancy Ureter (nephrectomy): Negative for malignancy Adrenal gland: Not received Lymph nodes: One lymph node, negative for carcinoma (0/1). Pathologic findings in non-neoplastic kidney: Focal glomerulosclerosis. AJCc Stage: pTlb pNO This staging information is based on information available at the time
+
+--- Page 2 ---
+of this report, and is subject to change pending clinical review and additional information. Comment: Immunostains were performed on block A2 and demonstrate the tumor is. positive for cDlo and c-kIr while being negative for cK7, Rcc, and. vimentin. A Hales colloidal iron shows patchy staining in tumor cells. Overall, these findings are most consistent with the chromophobe type of renal cell carcinoma.. Dr. has reviewed this case and concurs.. Clinical History: -year-old female with right renal mass. Gross Description:. Received is one appropriately labeled container: Specimen fixation: formalin. Type of specimen: radical nephrectomy Side of specimen: right Size and weight of specimen: 490.0 grams, 16.0 x 10.0 x 4.0 cm overall Kidney: 13.0 x 7.5 x 3.0 cm Orientation: Inking: surface of kidney-blue. Presence/absence of adrenal gland: absent Tumor site: superior pole; renal cortex. Tumor description: pink/tan, well circumscribed, with a single central cyst with a solid lining, and multiple areas of hemorrhage. Tumor size: 4.5 x 4.2 x 3.5 cm Presence/absence of multicentricity: absent Confinement/non-confinement to the kidney: confined. Extent of invasion:. Perirenal adipose tissue: does not involve
+
+--- Page 3 ---
+Gerota' s fascia: does not involve Renal vein: does not involve Ureter: does not involve Renal Sinus: does not involve Pelvicaliceal: does not involve Adrenal: not submitted Other organs: n/a Surgical margins:. Perirenal adipose tissue: negative Renal vein: negative Renal artery: negative Ureter: negative. Description of kidney away from tumor: Grossly unremarkable. Hilar lymph nodes: no palpable lymph nodes are identified. Other significant findings: none Tissue submitted for special investigations: Tumor and normal were. harvested by the Digital picture: none Block summary: Al - ureter, vein, artery and margins, en face A2 - tumor and normal parenchyma, closest blue inked margin. A3 - tumor and closest renal pelvis A4-A5 - tumor expanding capsule, closet blue inked margin. A6 - closest renal sinus, uninvolved A7 - normal kidney. A8-A9 - representative sections of hilar fat with possible lymph node candidate -8/3i/13 reast 30113
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index 0000000000000000000000000000000000000000..7ad73b85a80976bff3613873d1da750405efd6cd
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+
+--- Page 1 ---
+Case Report (For Collection of Cancerous Tissue) Informed Consent I personally informed this patient that a specimen(s) would be collected to be used for research purposes.I reviewed the RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the our institution. Name of Physician or Study Coordinator Signature Date Clinical Information GENERALINFORMATION SASY Date of Rirth (mm/dd/wwy) Height Marital Status Race Temperature Weight Blood Pressure Heart Rate ET HISTORY OFPRESENT ILLNESS blod w Xtsol Symptoms: weight Wgs Clinical Findings: Performance Scale (Karnofsky Score):.  100 Asymptomatic  80-90 Symptomatic but Fully Ambulatory  60-70 Symptomatic, in bed less than 50% of day  20-30 Bed Ridden ~ 40-50 Symptomatic, in bed more than 50% of day, but not bed ridden CURRENT MEDICATIONSS Dose Route Frequency Date (mm/dd/yyyy) Drug To To To To To
+
+--- Page 2 ---
+GPASTMEDICAL HISTORYES Diagnosis/Disease/Disorder/Injury Diagnosis Date Treatment Status SOCIALHISTORY Occupation: Environmental Hazards: Smoking History Current Status TYPE Packs/day Duration When Quit  YES >PNO (yrs) (yr) Alcohol Consumption Current Status TYPE Drinks/day Duration When Quit yES NO (yrs) (yr) Drug Use Current Status TYPE Frequency Duration When Quit YES NO (yrs) (yr) Diagnosis Age of Diagnosis Relative Test Result Date Test Result Date HIV CEA  Negative  Positive:  Negative  Positive: CA 15-3  Negative  Positive: Hep B KNegative  Positive: CA 19-9  Negative  Positive: Hep C Negative  Positive: PSA   Negative  Positive: AFP   Negative  Positive: Other: Other:  Negative  Positive:  Negative   Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+EDIAGNOSTICSTUDIES Study Results Date Ultrasound X-Ray CT Endoscopy  Was A MRI Lesxics in the iymoid! Biopsy CLINICALDIAGNOSIS Preoperative Clinical Diagnosis Location of Suspected Involved Lymph Nodes Location of Suspected Distant Metastasis Clinical Staging Doto DioanA T3 N MO Stage: Treatment Information. Procedure Sinmoi d wlletony.. Primary Tumor Organ. Detailed Location Size S Gmee/ csln 5 x Ax 3cm Celen LtmoR Extension of Tumor Lymph Nodes Description Location of Lymph Nodes. # of Lymph Nodes Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Organ Detailed Location Size Surgica! Staging NA Stage: Z/3 T 7 Mo NEOADJUVENT THERAPY Chemo RadiationImmuno Hormonal orMolecular Frequency Date (mm/dd/yyyy) Drug/Treatment Dose Route To 1 To / / To / To / To 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by: Date: Time Preserved by: Date Time SPECIMEN TYPE (#of samples provided Frozen Paraffin Block Blood/Serum/Plasma Slide Diseased Normal Diseased  Normal Diseased Normal Diseased  Normal A 2 Time to LN2 Time to Formalin Time to LN2 1 min /3 min min PATHOLOGICAL DESCRIPTION Primary Tumor Organ Size Extension of Tumor Distance to NAT ceol'n temer 5 x x 3 cm8med 6 cm Lymph Nodes Location # Examined # Metastasized CD len Deek Distant Metastasis Organ Detailed Location Size Pathological Staging pT 3 N A m O Stage:  Notes: Q qja(s (c7&Tks) colen noeles in nFTraGee B'Leej 1 neegtve
+
+--- Page 5 ---
+IAGNOSTIC PATHOLOGY FORM* Microscopic Appearance: Histological pattern: 1. CELL DISTRIBUTION Diffuse + STRUCTURAL PATTERN  Mosaic Y1 Streaming Necrosis  Storiform Lymphocytic Infiltration Y Fibrosis Vascular Invasion  Palisading Clusterized Cystic Degeneration Alveolar Formation Bleeding Indian File Myxoid Change  Psammoma/Calcification 2. Cellular features: Squamous + Adenomatous  Squamoid Cell Sarcomatous + Lymphomatous Glandular cell Spindle Cell Round Cell Large Cell Cell Stratification Fibroblast  Keratin Small Cell  Secretion Osteoblast Desmosome  RS Cell/RS Like Intracyt. Vacuole  Lipoblast  Pearl  Inflam. Cell  Gland formation  Myoblast  Plasma Cell Otherwise Specified: Di y0J Dr 907 Dz30% D4(LZ NesLosI 2.Cellular Differentiation: Well Moderately Poor 3. Nuclear Atypia: Nuclcar Appearance Aniso Nucleosis Hyperchromatism  Nucleolar Prominent Multinucleated Giant Cell  Mitotic Activity X Nuclear Grade Pasillari Kd(ersceleirgng b-) Histological Diagnosis:. M: Carnore xlep+ei?ed fo LU Comments: Yuor 2ydnshaaeu'Mn. THOLOGIST STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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index 0000000000000000000000000000000000000000..d9e58584364994cb5df4e89f165f7cdfa7d04c9f
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+
+--- Page 1 ---
+Clinical Diagnosis & History: biopsy), for left wide excision sLNb, possible left ALND. Specimens Submitted: 1: sp: Sentinel node #1 level one left axilla (fs) 2: Sp:  Sentinel node #2 level one left axilla (fs) 3: Sp: Excision of tumor left breast two o'clock 4: SP:  Superior margin left breast 5: Sp:  Medial margin left breast 6 : SP Inferior margin left breast 7: SP:  Lateral margin left breast UUID:D58E5D64-8589-4487-8E46-225AE3617C14 8: sp: Non-sentinel node left axilla TCGA-A0-A03F-01A-PR 9: Sp: Posterior margin left breast 10: sp: Levels one and two laft axillary contenta Redacted DIAGNOSIS: 1. LYMPH NODE, SENTINEL #1, LEVEL I, LEFT AXILLA; EXCISION: - METASTATIC ADENOCARCINOMA IN ONE LYMPH NODE (1/1). - THE METASTATIC FOCUS MBASURES 5 MM IN GREATEST DIMENSION. NEGATIVE FOR EXTRACAPSULAR BXTENSION. LYMPH NODE, SENTINEL #2 LEVEL I LEFT AXILLA; EXCISION: - METASTATIC ADENOCARCINOMA IN ONE LYMPH NODE (1/1). - THE METASTATIC FOCUS MEASURES 6 MM IN GREATEST DIMENSION. - EXTRACAPSULAR EXTENSION (>2MM) IS PRESENT. 3 BREAST, LEFT, 2 O'CLOCK; EXCISION: - INVASIVE DUCTAL CARCINOMA, NOS TYPE, HISTOLOGIC GRADE II/III (MODERATE TUBULE FORMATION), NUCLEAR GRADE I/III (SLIGHT OR NO VARIATION IN SIZE AND SHAPE), MEASURING 2.O CM IN LARGEST DIMENSION MICROSCOPICALLY. - DUCTAL CARCINOMA IN SITU (DCIS) IS ALSO IDENTIFIED, SOLID TYPE WITH LOW TO INTERMEDIATE NUCLEAR GRADE. - THE DCIS CONSTITUTES LESS THAN OR EQUAL TO 25% OF THE TOTAL TUMOR MASS, AND IS PRESENT ADMIXED WITH THE INVASIVE COMPONENT. - CALCIFICATIONS ARE PRESENT IN THE INVASIVE CARCINOMA ONLY. - FOCAL VASCULAR INVASION IS PRESENT. - FOR SURGICAL MARGINS SEE PARTS 4-7, - THE NON-NEOPLASTIC BREAST TISSUE THE NON-NEOPLASTIC BREAST TISSUE AND 9. ** Continued on next page ** Ics-0-3 carciona, vifiltrat'mg duct, nios 850c/3 Site bsst, Nis iagnosis
+
+--- Page 2 ---
+SHOWS BIOPSY SITE CHANGES Page - RESULTS OF SDDATa rre /R, PR, HER2-NEU) ARE AS FOLLOWS: 'ESTROGEN RECEPTOR 95% nuclear staining wi+ tntensity PROGESTERONE RECEPTOR 70% nucles. ith moderate intensity HER2 Negative (1+) (<5% of invasive tumor cells exhibit weak complete membranous staining; Uniformity of staining: absent: Homogeneous, dark circumferential pattern: absent) Comment: Controls are satisfactory. PATHWAY anti-HER-2/neu is an FDA-approved rabbit monoclonal primary antibody (clone 435) directed against the internal domain of the c-erbb-2 oncoprotein (Her2) for imminohistochemical detection of Her2 protein overexpression in breast cancer tissue routinely processed for histologic evaluation. The HBR2 test results are reported in accordance with the Asco/CAP guideline recommendations for HeR2 testing in breast cancer (J clin Oncol 2007; 25(1):118-145). The ER and PR rabbit monoclonal antibodies are also FDA approved. 4. BREAST, LEFT, SUPERIOR MARGIN; EXCISION: - BENIGN BREAST TISSUE WITH PROLIFERATIVE FIBROCYSTIC CHANGES. BREAST, LEFT, MEDIAL MARGIN; RXCISION: - BENIGN BREAST TISSUE WITH FOCAL USUAL DUCTAL HYPERPLASIA. 6. BREAST, LEFT, INFERIOR MARGIN; EXCISION: - BENIGN BREAST TISSUE WITH FOCAL USUAL DUCTAL HYPERPLASIA. 7. BREAST, LRFT, LATERAL MARGIN; EXCISION: Z - BENIGN BREAST TISSUE WITH FOCAL USUAL DUCTAL HYPERPLASIA 8. LYMPH NODE, NON-SENTINEL, LEFT AXILLA; EXCISION: -ONE BENIGN LYMPH NODE (O/1). 9. BREAST, LEFT, POSTERIOR MARGIN; BXCISION: - BENIGN BREAST TISSUE PREDOMINANTLY COMPOSED OF FIBROADIPOSE ELEMENTS. SKELETAL MUSCLE TISSUE ALSO PRESENT. 10. LYMPH NODES, LEFT AXILLARY CONTENTS, LEVELS ONE AND TWO, EXCISION: ELEVEN BENIGN LYMPH NODES (0/11). Some of the immnohistochemistry and :ests were developed and their performance characteristics were determined by They have not been cleared or approved by the us yooa ana urug Administration. The FDA has determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for research. This laboratory is certified qualified to perform high complexity clinical laboratory testing. * Continued on naxt page
+
+--- Page 3 ---
+Page I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL). AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. *** Report Electronicasly Signed Out Gross Description:. 1) The specimen is received fresh for frozen labeled, "Sentinel node #1, level 1, left axilla". and consists of one fatty lymph node measuring 2.5 x. 1.5 x 1.5 cm, which is trisected and representatively submitted. A portion Of tissue sent to tps. The remaining lymph node is submitted to permanent.. Summary of sections:. fsc -- lymph node frozen section control RS-  remaining lymph node ). 2) The specimen is received fresh for frozen labeled, "Sentinel node #2, lavel 1. left axilla", and consists of one fatty lymph node measuring 2.4 x. 1.5 x 1.2 cm, which is trisected and representatively submitted.. A portion of tissue sent to tps.. The remaining lymph node is submitted to permanent. Summary of sections: fsc -- lymph node frozen section control RS- remaining lymph node 3) The specimen is received unoriented and fresh, labeled "excision of tumor, left breast two o' clock" and consists of a piece of fibrofatty breast tissue measuring 5.2 x 5.0 x 2.3 cm. The specimen is entirely inked. black.  Serial sectioning reveals a spiculated, white mass measuring 1.2 x 1.2 x 1.1 cm. Sectioning through the remaining breast tissue reveals yellow adipose tissue. A clip is identified. The tumor is entirely submitted and the remaining tissue is representatively submitted and a small portion is given to Tps. Summary of sections:. MT - tumor and closest tisaue edge. tumor (clip was in block 2) Ss - serial sections remaining tissue 4) The specimen is received fresh, labeled "superior margin left breast" and. consists of a piece of fibrofatty breast tissue measuring 5.0 x 3.0 cm, and. 1.3 cm thick. "A stitch marks the new margin of excision, which is inked black. The tissue is serially sectioned and entirely submitted.. ** Continued on next page *.
+
+--- Page 4 ---
+Sunmary of sections: u - sequential sections 5) The specimen is received fresh, labeled "medial margin left breast" and consists of a piece of fibrofatty breast tissue measuring 3.2 x 2.5 cm, and 1.2 cm thick. ~A stitch marks the new margin of excision, which is inked black. The tissue is serially sectioned and entirely submitted. Sumnary of sections: u - sequential sections 6) The specimen is received fresh, labeled "inferior margin left breaat" and consists of a piece of fibrofatty breast tissue measuring 4.0 x 3.0 cm, and 1.3 cm thick. 'A stitch marks the new margin of excision, which is inked black. The tissue is serially sectioned and entirely submitted. Summary of sections: u - sequential sections 7) The specimen is received fresh, labeled "lateral margin left breast" and consists of a piece of fibrofatty breast tissue measuring 4.4 x 2.8 cm, and 1.3 cm thick. "A stitch marks the new margin of excision, which is inked black.  The tissue is serially sectioned and entirely submitted. Summary of sections: u - sequential sections 8). The specimen is received in formalin, labeled "Non-sentinel node left axilla" and consists of a single pink tan fatty lymph node measuring 0.9 cm. The lymph node is bisected and entirely submitted. Summary of sections: BLN-bisected lymph node 9). The specimen is received fresh, labeled "posterior margin, left breast" and consists of a piece of fibrofatty breast tissue measuring 4.2 x 3.0 cm, and 0.5 cm thick.  The specimen is unoriented, entirely inked black sectioned and submitted in its entirety. Summary of sections: Ss - sequential sections 10) The specimen is received fresh labeled *levels one and two left axillary contents". It consists of a fragment of yellow adipose tissue measuring 12.5 ** Continued on next page **
+
+--- Page 5 ---
+Page 5 of 6 x 10.5 x 2 The levels not designated. Numerous  lymph nodes are identified ranging in size from 0.4 cm up to 2.0 cm, and Summary: RLN-representative lymph node (multiple) ARLN-additional  representative lymph nodes LN-lymph nodes Summary of Sections: Part 1: SP: Sentinel node #1 level one left axilla (fs) Block Sect. Site PCs 1 fsc 1 1 1 rs Part 2: SP: Sentinel node #2 level one left axilla (fs) Block Sect. site PCs fsc 1 1 rs Part 3: SP: Excision of tumo two o'clock Block S Sect. Site PCs 1 MT 1 H N ss 1 T 2 Part 4: SP Superior margin left breast Block Sect. site PCs 6 u Part 5: SP: Medial margin left breast Block Sect. Site PCs 6 u Part6: SP: Inferior margin left breast Sect. Site PCs Block 6 u Part 7: SP: Lateral margin left breast Block Sect. Site PCs 6 u Part 8: SP: Non-sentinel node left axilla
+
+--- Page 6 ---
+Page 6 of 6 Sect. Site Block PCs bln 1 Part 9: SP  left breas! Block Sect. Site PCs 6 ss 6 Part 10: SP: Levels one and two left axillary contents Sect. site Block PCs 5 arln 5 5 LN 12 4 RLN 4 Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the tissue sample. examined at the time of the intraoperative consultation. 1) FROzeN SEcTIOn DIaGNOsIs: Sp: Sentinel node #1 level one left axilla (fs) : Metastatic ductal carcinoma. (1/1) PERMANENT DIAGNOSIS: SAME 2) FROZEN SECTION DIAGNOSIS: SP: Sentinel node #2 level one left axilla (fs):  Metastatic ductal carcinoma with extranodal extension. (1/1) PERMANENT DIAGNOSIS: SAME Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 1) FROzeN SEcTION DIaGNOSIS: Sp: Sentinel node #1 level one left axilla (fs) : Metastatic ductal carcinoma. (1/1) PERMANENT DIAGNOSIS: SAME 2) FROZEN SEcTION DIAGNOsIs: Sp: Sentinel node #2 level one left axilla (fs): Metastatic ductal carcinoma with extranodal extension. (1/1) PERMANENT DIAGNOSIS: SAME ** End of Report **
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diff --git a/output/text/095d4c1e-014c-4b60-a330-5f08f074f7aa.txt b/output/text/095d4c1e-014c-4b60-a330-5f08f074f7aa.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c6f848ce34f195358f87be657d52639811881337
--- /dev/null
+++ b/output/text/095d4c1e-014c-4b60-a330-5f08f074f7aa.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Sit Frast Nos c s0.9 12.1/1 Procedure Date: Procedure Physician: Attending Physician/Copies To:e UUID:FF6BC87F-029E-4565-A35A-6FB968F8EABA TCGA-BH-A1EU-01A-PR Redacted Patient hIstory: PATH HAS SPECIMEN nnDATE of LMP: DATE OF LAST DELIVERY: PRE-OP DIAQNOSIS: R BREAST CA POST-OP DIAGNOSIS: SAME OPERATIVE PROCEDURE: R SEGM MAST CLINICAL HISTORY: PATH HAS SPECIMEN MATERIAL SUBNITTED:~RIGHT BREAST BIOPSY/MASS/SEGMENTAL MASTECTOMY, PROCUREMENT BY SURGICAL PROCEDURE INTRAOPERATIVE CONSULTATION: cOnsuLt: Right breast: 8.0 by 7.0 by 2.5 cm, with 1.7 by 1.5 by 1.5 cm tumor. All margins grossly negative. ADDENDA: Addendum FINAL DIAGNOSIS: ER/PR DOMUNOPEROXIDASE IDENTIFICATION Or LSTROCEN AND PROGESTERONE RECEPTORS IS CARRIED OUT ON SLIDE SM "A1". DISTINCT INTRANUCLEAR STAINING IS IDENTIFIED FOR LSTROGEN RECEPTOR (9St) AND PROCESTERONE RECEPTOR (9St). THEREFORE, BOTH ARE INTERPRSTED AS POSITIYE HER-2/NEU C-erbB2 (HER-2/NEU) IMMUNOSTAININC IS CARRIED OUT ON MAGEE SURGICAL BLOCK nD2 (BREAST CANCER) USING A 1:3OO DILUTION Or DAKO'S POLYCLONAL ANTIBODY A48S' (DIRECTED AGAINST THE INTRACSLLULAR DCMAIN OF c- GrbB2) WITSOUT ANTIGEN RETRIEVAL. NO DISTINCT CONPLETE MEMBRANE STAINING IS. IDENTIRIED. THEREFORS, C-erbB2 (HER-2/NEU) IS INTERPRETED AS NEGATIVE (SCORE O FINAL DIAGNOSIS: PINAL DIAGNOSIS: RIGHT SEGMENTAL MASTECTOMY: INEILTRATING DUCTAL CARCINOMY, INTERMEDIATE HISTOLOGIC AND NUCLEAR GRADE - NOTTINGHAM SCORE 5 SIZE OF TUMOR 1.7 CM - RETROGRADE EXTENSION INTO LOBULES IS SEEN LYMPHOCYTIC INFILTRATION SEE MICROCALCIFICATIONS - PROLIFERATIVE FIBROCYSTIC CHANGES AND INTRADUCTAL PAPILLOMA SCLEROSING ADENOSISS MARGINS ARE FREE
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diff --git a/output/text/09805fcb-892c-4f87-bb9c-06582a2f18c6.txt b/output/text/09805fcb-892c-4f87-bb9c-06582a2f18c6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a7a178ec02284bc61dc203385b859c7d1affd2a4
--- /dev/null
+++ b/output/text/09805fcb-892c-4f87-bb9c-06582a2f18c6.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID: BC932F39-646E-4E75-A1E6-EAE524A78F79 TCgA-G7-A8LB-01A-PR Redacted 7CD6 3 areinomo, ypoapelsery nerol 8x6t/3 eese SPECIMENS: A. FAT OVERLYING TUMOR B. LEFT KIDNEY TUMOR BASE ? CA. C649 C. LEFT KIDNEY TUMOR JtJ u1) 24l13 SPECIMEN(S): A. FAT OVERLYING TUMOR B. LEFT KIDNEY TUMOR BASE ? CA. C. LEFT KIDNEY TUMOR DIAGNOSIS: A. LEFT KIDNEY, FAT OVERLAYING TUMOR, EXCISION: - MATURE ADIPOSE TISSUE, NEGATIVE OR MALIGNANCYE B. LEFT KIDNEY, TUMOR BASE, BIOPSY: - BENIGN RENAL TUBULES WITH FIBROSIS, NEGATIVE FOR MALIGNANCYE C. LEFT KIDNEY, PARTIAL NEPHRECTOMY: - PAPILLARY RENAL CELL CARCINOMA, MIXED TYPE I AND II PATTERNSE - FUHRMAN NUCLEAR GRADE 3 - TUMOR SIZE: 9 X 6 X 4.5 CM - MICROSCOPIC FOCUS OF.TUMOR PRESENT ON THE INKED SPECIMEN EDGE (PLEASE REFER TO PART B AND SYNOPTIC REPORT FOR FINAL MARGIN STATUS) - TUMOR CONFINED TO THE KIDNEY - SEE SYNOPTIC REPORT SYNOPTIC REPORT - KIDNEY (PARTIAL OR RADICAL) Specimens Involved Specimens: A: FAT OVERLYING TUMOR B: LEFT KIDNEY TUMOR BASE ? CA. C: LEFT KIDNEY TUMOR Specimen Type: Partial nephrectomy Without adrenal gland Laterality: Left Tumor Site: Not specified Focality: Unifoca! Tumor Size (largest tumor if multiple): Greatest dimension: 9cm Additional dimensions: 6cm x 4.5cm Macroscopic Extent of Tumor:  Tumor limited to kidney WHO CLASSIFICATION Papillary renal cell carcinoma 8260/3 Histologic Grade (Fuhrman Nuclear Grade): G3: Nuclei very irregular, approximately 20 u; nucleoli large and prominent Invasion of Vascular/Lymphatic: Absent Perinephric Tissue Invasion:  Absent Margins:  Margins uninvolved by invasive carcinoma Adrenal Gland: Not present Regional Lymph Nodes:  None sampled Additional Findings: None identified Pathological Staging (pTNM): pT 2a N X M X Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition. GROSS DESCRIPTION: A. FAT OVERLYING TUMOR
+
+--- Page 2 ---
+Received in formalin labeled with the patient's identification and 'fat overlying tumor' is a tan yellow fragment of fibrofatty tissue 14 x 4 x 3cm. Dissection reveals unremarkable adipose tissue.. Representatively submitted in A1-A3. B. LEFT KIDNEY TUMOR BASE ? CA. Received fresh for frozen section labeled with the patient's identification and 'left kidney tumor base? CA' is a tan pink soft tissue fragment 0.3 x 0.2 x 0.1cm. A touch prep is taken. Toto FSB.. C. LEFT KIDNEY TUMOR Received fresh labeled with the patient's identification and 'left kidney tumor' is an oriented 320g, 9 x 6.5 x 6cm partial nephrectomy specimen with attached peri-nephric adipose tissue 8 x 6 x 3cm. The capsule is tan pink, smooth, intact and inked black. The 8 x 6cm resection margin is inked green. The  most deep surgical resection margin is designated by the surgeon and inked blue. The specimen is serially sectioned perpendicular to the resection margin to reveal a 9 x 6 x 4.5cm yellow-red, partially necrotic mass, abutting the deep resection margin and the capsule. Gross photographs are taken. A portion of the specimen is submitted for tissue procurement. The peri-nephric adipose tissue is serially sectioned. The mass grossly appears to be confined to the kidney. Representatively submitted: C1-C2: deepest resection margin C3-C8: mass C9-C10: peri-nephric adipose tissue CLINICAL HISTORY: None Given PRE-OPERATIVE DIAGNOSIS: Left kidney tumor. INTRAOPERATIVE CONSULTATION: FSB-TPB: Left kidney tumor base ? CA- Suspicious for oncocytic neoplasm. Dr. has review this case  and agrees with the diagnosis and interpretation. Diagnosis called to Dr. at by Dr. Gross Dictation: Pathologist, Microscopic/Diagnostic Dictation: Final Review:., Pathologist, Final: Pathologist, W n/4/!
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diff --git a/output/text/09806bc6-83d6-4fad-ba36-0541f72a8f28.txt b/output/text/09806bc6-83d6-4fad-ba36-0541f72a8f28.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8a19c0622f9877fbe9a4da0da4292516a480e763
--- /dev/null
+++ b/output/text/09806bc6-83d6-4fad-ba36-0541f72a8f28.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SPECIMENS: A. RIGHT OVARIAN CYST B. LEFT OVARIAN CYST C. LEFT COLON, SIGMOID, UPPER RECTUM D. DISTAL DONUT E. PROXIMAL DONUT F. SMALL BOWEL NODULE DIAGNOSIS: A. SOFT TISSUE, RIGHT OVARY, EXCISION:  SEROUS CYSTADENOMA. B. SOFT TISSUE, LEFT OVARY, EXCISION: - SEROUS CYSTADENOMA. C. RECTOSIGMOID COLON, SEGMENTAL RESECTION: - INVASIVE MODERATELY DIFFERENTIATED ADENOCARCINOMA WITH ULCERATION - TUMOR SIZE 5 CM. - TUMOR INFILTRATES INTO THE SUBSEROSA. - MARGINS ARE NEGATIVE FOR CARCINOMA. - TUBULAR ADENOMA. - TWO OF SEVENTEEN LYMPH NODES POSITIVE FOR METASTATIC CARCINOMA (2/17).  SEE TEMPLATE. D. COLON, DISTAL DONUT, EXCISION: - COLONIC TYPE MUCOSA WITH NO PATHOLOGICAL ABNORMALITY. - NEGATIVE FOR CARCINOMA E. COLON, PROXIMAL DONUT, EXCISION: - COLONIC TYPE MUCOSA WITH NO PATHOLOGICAL ABNORMALITY. - NEGATIVE FOR CARCINOMA. F. SOFT TISSUE, SMALL BOWEL, EXCISION: ENDOSALPINGIOSIS, NEGATIVE FOR MALIGNANCY. COLORECTAL CANCER TEMPLATE Specimen Type: Rectal/rectosigmoid colon (Lower anterior resection) Tumor Site: Sigmoid Colon Tumor Configuration: Exophytic (polypoid). Tumor Size: 5 x 4 x 3 cm. Histologic Type: Adenocarcinoma Histologic Grade: G2: Moderately differentiated Extent of Invasion: Subserosa Margins: Margins uninvolved by invasive carcinoma (Proximal, Distal, Radial) Venous/Lymphatic Invasion: Present Perineural Invasion: Absent Additional Pathologic Findings: Adenoma. Extent of Resection: R0: Complete resection with grossly and  microscopically negative margins Lymph Nodes: Positive (2/17) Extranodal extension  Implants: Absent Pathologic Stage: pT3a N1 MX SPECIMEN(S): A. RIGHT OVARIAN CYST B. LEFT OVARIAN CYST C. LEFT COLON, SIGMOID, UPPER RECTUM D. DISTAL DONUT E. PROXIMAL DONUT F. SMALL BOWEL NODULE
+
+--- Page 2 ---
+GROSS DESCRIPTION: A. RIGHT OVARIAN CYST Received fresh labeled with patient's name and "right ovarian cyst" is a 2.0 x 1.0 x 0.8 cm pink-tan. cystic soft tissue fragment. A section is submitted for frozen section in FSA1 and the remainder of the specimen is submitted in cassette A2. B. LEFT OVARIAN CYST Received fresh labeled with patient's name and "left ovarian cyst" is a 1.5 x 0.4 x 0.3 cm pink-tan soft tissue fragment. The specimen is entirely submitted for frozen section in FSB1.. C. LEFT COLON, SIGMOID, UPPER RECTUM Received fresh and labeled with patient's name and "left colon, sigmoid and upper rectum" is a segment of colon and rectum, measuring 20 cm in length and 6 cm in open circumference. The serosa is smooth. There is a pink-tan fungating mass 4 x 5 x 3 cm, located 4 cm from the rectal margin and 9.5 cm from the colonic margin. It appears to invade into the muscularis propria. There is a 0.7 x 0.4 x 0.3 cm. polyp located 0.5 cm from the mass towards the proximal colonic margin. Sixteen possible lymph nodes are found ranging in size from 0.4 to 1.7 cm in greatest dimension. Representative sections are submitted as follows: C1: colonic margin C2: rectal margin C3-C5: mass and deep margin C6: mass with polyp C7: representative sections of normal appearing colonic mucosa C8: five possible lymph nodes C9: five possible lymph nodes C10: four possible lymph nodes C11-C13: one bisected lymph node each D. DISTAL DONUT Received in formalin and labeled with the patient name and "distal donut" is a ring of tan mucosa tissue measuring 0.9 cm in length with an outer circumference of 1.6 cm. It is bisected and there is a stapled surgical line present. The specimen is submitted in toto in cassette D1. E. PROXIMAL DONUT Received in formalin and labeled with the patient name and "proximal donut" is a ring of tan mucosa tissue with an outer circumference of 1.9 cm and measuring 0.8 cm in width. There are blue sutures present throughout the specimen. The specimen is submitted entirely in cassette E1.. F. SMALL BOWEL NODULE Received fresh for frozen section evaluation labeled with the patient's name and "small bowel nodule excision" is a fragment of tan soft tissue measuring 2.0 x 0.5 x 0.4 cm. The tissue is bisected to show a firm white nodule measuring 1 x 0.5 x 0.5 cm. The entire specimen is submitted in a cassette FSF1. ADDENDUM: ANALYSIS OF MISMATCH REPAIR PROTEIN EXPRESSION MLH1 Expression: Present MSH2 Expression: Present MSH6 Expression: Present PMS2 Expression: Present Expression of MLH1, MSH2, MSH6, and PMS2 in the tumor was evaluated by immunohistochemistry. Peritumoral lymphocytes and normal glands serve as internal positive controls expressing MLH1, MSH2, MSH6, and PMS2. Testing for Microsatellite Instability has been ordered. The results will be issued in a separate report.
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diff --git a/output/text/0a4a4e16-21c4-4606-a3b4-0cc33fc0ba41.txt b/output/text/0a4a4e16-21c4-4606-a3b4-0cc33fc0ba41.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8010478898c9ab5e6ed68db742631b36202277e0
--- /dev/null
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+
+--- Page 1 ---
+zcd-o-3 UUID: 1CF258D1-C0B7-471A-B2DB-A0CC377AD908 Csrcereme TCGA-D6-A6EM-01A-PR Redacted Nas 8070/3 AJ s5/z411_3 Department of Cancer Pathology. Patient: XXX Age: Gender: F Examination result No.. Unit in charge: Surgery and Laryngological Oncology Dept.  Physician in charge: Clinical diagnosis (suspicion) Cancer of the tongue Date of admission: Material: 1) Material: oral cavity - tongue. Please mark surgical margins. Method of collection: Collection of  specimens for laboratory examination Histopathological diagnosis Examination performed on:. Squamous cell carcinoma of the tongue Assistant: Pathologist: Edited by . CONTACT YOUR DOCTOR WITH THIS REPORT! hj s[2q|r3
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diff --git a/output/text/0a4a8a04-0bcf-408b-b6b2-a54391ee384b.txt b/output/text/0a4a8a04-0bcf-408b-b6b2-a54391ee384b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0118f8d03936dd2e47483a9f048cb6666f741a44
--- /dev/null
+++ b/output/text/0a4a8a04-0bcf-408b-b6b2-a54391ee384b.txt
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+
+--- Page 1 ---
+Diagnosis: 1.: Colon resection material (sigmoid) with tumor-free, oral and aboral resection margins. includes an ulcerated, moderately differentiated adenocarcinoma with infiltration of the lamina muscularis propria and solitary regional lymph node metastases (G2, pT2 pN1 1/26 L1, V0, R0). 2.: Inflammation-free small intestine or Meckel's diverticulum without evidence of tissue heterotopy.
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diff --git a/output/text/0a6c5ec9-da46-42de-8d21-6e9afd2325f4.txt b/output/text/0a6c5ec9-da46-42de-8d21-6e9afd2325f4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..87a2adf9085c1eab55d26662af0b2e5b6888d1dc
--- /dev/null
+++ b/output/text/0a6c5ec9-da46-42de-8d21-6e9afd2325f4.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+1CA-0-3 TSS: Caciomr,nfi1trsHng ductl, nos 8500/3 Sin: srast Nos C50.9 1/15/11 SPECIMENS: A. SENTINEL LYMPH NODE BX #1 RIGHT AXILLA B. SENTINEL LYMPH NODE BX #2 RIGHT AXILLA C. WIDE EXCISION RIGHT BREAST D. RIGHT BREAST CYST E. RE-EXCISION INFERIOR LATERAL MARGIN-RIGHT BREAST DIAGNOSIS: A. LYMPH NODE, SENTINEL #1, RIGHT AXILLA, EXCISION: ONE LYMPH NODE, NEGATIVE FOR TUMOR (0/1). LYMPH NODE, SENTINEL #2, RIGHT AXILLA, EXCISION: ONE LYMPH NODE, NEGATIVE FOR TUMOR (0/1). C. BREAST, RIGHT, WIDE EXCISION: -INVASIVE POORLY DIFFERENTIATED DUCTAL CARCINOMA WITH LOBULAR EXTENSION OF RIGHT BREAST (SBR GRADE 3) -SIZE OF TUMOR: 1.5x1.5x1.2cm -MARGINS OF RESECTION: FREE OF TUMOR -BLUNT DUCT ADENOSIS AND FOCAL SCLEROSING ADENOSIS -FOCAL DUCT ECTASIA D. Right Breast Cyst, eXcIsION: -CONISITENT WITH RUPTURED APOCRINE RETENTION CYST WITH REACTIVE ATYPIA; AND PERIDUCTAL FIBROSIS WITH GRANULATION TISSUE -CYSTIC AND PAPILLARY APOCRINE CHANGE -FOCAL BLUNT DUCT ADENOSIS -FOCAL PERIDUCTAL DUCT ECTASiA (NEGATIVE fOR TUMOR)  RIGHT BREAST, RE-EXCISION-INFERIOR LATERAL MARGIN: -DUCTAL CARCINOMA IN SITU WITH LOBULAR EXTENSION (SOLID PATTERN) ,HIGH NUCLEAR GRADE .see note - STROMAL FIBROSIS ,FOCAL PERIDUCTAL MASTITIS -CYSTIC APOCRINE CHANGE WITH MICRO AND COARSE CALCIFIACTION Note: Slide#E1-represents section from new margin that shows extension of DCiS involving. 3 lobular acini. There is no stromal invasion.. Slide#E6-focus of DCIS measures 8x5 mm, and in#E4-6x4 mm. Invasive Breast Cancer Template UUID:DA817488-862D-49BE-9BA4-9C11C44893053 TCGA-E2-A1LH-01A-PR Redacted INVASIVE TUMOR: Histologic type: ductal. Tumor Size (cm): 1.5x1.5x1.2cm Size of Invasive Focus: 1.5x1.5x1.2cm Grade, Histologic: 3 Grade, Nuclear: 3 Mitoses (Olympus 40x): 3 Scarff Bloom Richardson grade: III Necrosis: absent Invasion Vasc/Lymphatic: absent DCIS component DCIS Quantity:  <25% DCIS Type: solid DCIS Location: inside and outside main mass Nuclear grade: high Necrosis: present Margins: see note Lymph nodes: negative (0/2) sentinel lymph nodes Stage, Pathology : pT1c
+
+--- Page 2 ---
+TSS: Non-neoplastic areas: Hormone receptor status (by IHC): ER: pending. PR: pending HERCEPTEST (by IHC): pending Pathologist Electronically signed - ADDENDUM The ER/PR/HER2 status of the invasive breast carcinoma was determined by immunohistochemistry and quantitated via ACiS (image analysis). Results are as follows: Er 0% PR 0% HER2 0.0% A separate ACIS report has been generated.. NOTE: FiSH analysis for HER2 gene amplification has not been ordered. SPECIMEN(S): A. SENTINEL LYMPH NODE BX #1 RIGHT AXILLA B. SENTINEL LYMPH NODE BX #2 RIGHT AXILLA C. WIDE EXCISION RIGHT BREAST D. RIGHT BREAST CYST E. RE-EXCISION INFERIOR  LATERAL MARGIN-RIGHT BREAST CLINICAL HISTORY: Right breast ca. FROZEN SECTION DIAGNOSIS:E A. SENTINEL LYMPH NODE #1 RIGHT AXILLA Touch prep: No tumor seen on touch prep. B. SENTINEL LYMPH NODE BIOPSY #2 RIGHT AXILLA Touch prep: No tumor seen on touch prep, reported to Dr. by Dr. a C. WIDE EXCISION RIGHT BREAST Gross only: Tumor about 0.8cm. from anterior margin, reported to Dr. by Dr. GROSS DESCRIPTION: A.  SENTINEL LYMPH NODE BIOPSY #1 RIGHT AXILLA Received fresh in a single container labelled and designated "sentinel lymph node bx #1 right axilla" and consists of a single 1.5x1.1x0.4cm. lymph node with tan cut surfaces and associated unremarkable adipose tissue. A touch preparation is made from the lymph node. The entire specimen is submitted in. a single cassette labelled A1.. B.  SENTINEL LYMPH NODE BIOPSY #2 RIGHT AXILLA Received fresh in a single container labelled and designated "sentinel lymph node bx #2 right axilla" and consists of a single 1.3x1.3x0.4cm. lymph node with tan cut surfaces and associated unremarkable adipose tissue. Touch preparations are made from the lymph node. The entire specimen is submitted in a single cassette labelled B1.. C. WIDE EXCISION RIGHT BREAST Received fresh in a single container labelled and designated "wide excision right breast cancer with needle iocalization" and consists of a single 8.5x7.5x3.0cm. resected portion of breast tissue. A single. stitch of suture indicates the anterior aspect and a double stitch indicates the lateral aspect. A.
+
+--- Page 3 ---
+TSS. Iocalization wire is present within the specimen. A radiograph is also received with the specimen and shows a radiographic density in the region of the tip of the wire. The margins of resection is inked as follows: inferior orange, superior red, lateral yellow, anterior blue, medial green, posterior black. The specimen is serially sectioned from superior to inferior and a 1.5x1.5x1.2cm. tan grey well circumscribed tumor is identified. The tumor does not approach any of the margins grossly. However, it is within approximately 0.8cm. of the anterior (blue) margin. The tumor is at least 1.5cm. away from all the other margins. A small portion of tumor is submitted for tissue procurement as well as a portion of uninvolved breast parenchyma. The remainder of the cut surfaces are remarkable only for multiple small cystic nodules all 0.3cm. in diameter or less. Multiple sections including approximately 95% of the tumor are submitted and labelled as follows:.. Code of sections: C1-C2: tumor approaching anterior margin. C3: tumor C4-C5: tissue adjacent to medial margin C6-C9: breast with cystic nodules D.  RIGHT BREAST CYST,excision Received in formalin in a single container labelled and designated *right breast cyst" and consists of a single portion of firm tan yellow fibrofatty tissue measuring 3.7x2.7x2.2cm. No orientation is given. The resection margin is inked. The specimen is serially sectioned and located centrally is a 1.2cm. diameter cyst. The inner lining is smooth and tan. The remainder of the cut surfaces are composed of unremarkable adipose tissue with streaks of breast parenchyma. All of the cyst is submitted in cassettes D1 through D6.  RE-EXCISION INFERIOR LATERAL MARGIN RIGHT BREAST Received in formalin in a single container labelled and designated "re-excision inferior lateral margin right breast" and consists of a portion of tissue measuring 2.0x1.7x1.5cm. A short stitch of suture indicates the inferior aspect of the specimen and a long stitch indicates the lateral aspect which is the new margin. The new margin submitted in a single cassette labelled E1 en face. The remainder of the specimen is serially sectioned and the cut surfaces show unremarkable adipose tissue and breast. parenchyma.Remainder of specimen submitted and labelled E2-E9. Gross Dictation: Pathology Fellon Microscopic/Diagnostic Dictation: ratnologist, 1. Final Review: Pathologis Final: Pathologist, Addendum: Pathologist Addendum Review: Pathologist, Addendum Final: Pathologis'
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diff --git a/output/text/0a7a6ddf-aba9-438b-a830-deb3cca9303b.txt b/output/text/0a7a6ddf-aba9-438b-a830-deb3cca9303b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..01026d6f2ba451fe592366b2dd3f618c008b28a6
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:81022A25-6D64-419D-9897-22348E17ECEA Redac Requesting Doctor's Information:. 1 ICD-t3 Carcincino, Odreral ssrtical. 8378/3 Dite : Adrenol Clud,Cortex C74.D JrS.i|3s]13 A SPECIMEN TYPE:Adrenal T CLINICAL NOTES: H Right adranal. yo male, few months H/O fevers, weight loss. R) adrenal 0 mass on CT -> malignant cells on FNAB ?type. NOT lymphoma of melanoma. B/H hep C+ve. Rheumatic heart disease. ?primary adrenal tumour. ?metastasis. L 0 MACROSCOPIC: "Right adrenal gland". The specimen cansists of adrenal gland and surrounding G adipose tissue which is haemorrhagic in nature. The specimen measures 80 x 65 Y x 60mm and weighs approximately 125g. The surrounding adipose tissue is markedly congested and haemorrhagic. On sectioning, at least 70 to 80% of the adrenal gland has been replaced by tumour. It has a heterogeneous appearance with solid white areas, tibrous bands, and a large area of haemorrhage. In a few areas, the tumour appears to be abutting the resection margin. Blocks 1 to 4 - contain a representative section through the adrenal and adrenal mass, the slice has been sectioned into four pieces. Blocks 5 to 7 - contain representative tissue of tumour in areas where it appears to abut the surrounding resection margins (blocks 6 and 7 contains areas of haemorrhage). (A small amount ot tissue has been taken tor EM).. A N A MICROSCOPIC: Sections show adrenal tissue which has been largely replaced by a neoplastic T Intiltrate consisting of solid sheets of highly pleomorphic cells, most of which contain abundant eosinophilic cytoplasm. The nuclei are enlarged, 0 vesicular and have prominent nucleoli. Mitotic figures are numerous and M include a conspicuous number of atypical forms. The tumour has an infiltrative border and is seen invading both residual, cortical and medullary tissue. No penetration of the adrenal capsule is however evident. Many areas of necrosis c and haemorrhage are present. No vascular space permeation is seen. The following immunohistochemical stains were performed:. A S100: Occasional scattered cells staining positive, possibly representing origin from the residual adrenal medulla. L Chromogranin: Tumour cells negative. Positive staining of residual cells of medullary origin. HMB45: Negative. P CK7: Negative. A CK20: Negative. Cam5.2: Occasional scattered cells with pleomorphic characteristics show weak T positive staining. H 0 L n
+
+--- Page 2 ---
+Requesting Doctor's Information: P T SPECIMEN TYPE: Adrenal H Vimentin: Positive. 0 EMA: some apparent positivity. L CEA: Negative. AFP: Negative. 0 SMA: Negative. Electron microscopy was performed at Report G as follows: Y "Whilst there are features suggestive of an adrenal cortical carcinoma, the standard of preservation is too poor for firm diagnosis. Pleomorphic tumour cells are in close apposition with their neighbours and, where plasma membranes are preserved, lack intercelular junctions. Patches of. cytoplasm in some cells are occupied by what is probably altered smooth surfaced endoplasmic reticulum. However, although mitochondria are trequently numerous, they are too autolysed to determine whether the tubular or tubulovesicular cristae typical of adrenal cortical cells and their tumours are. present. Rough surfaced endoplasmic reticulum tends to occur in long strands, rather than in the short stacked cisternae, that characterises adrenal cortical 4 cells. Lipid droplets, though present, are not particularly numerous. N  There are no features (such as melanosomes, secretory granules, tonofibrils, A Iumen formation or microvilli) that would suggest metastatic tumour". T Reported by: 0 M COMMENT: The overall appearances/findings are considered most conslstent with those ot a primary adrenal cortical carcinoma. c A L P REPORTING PATHOLOGIST: I:132|1) (Electronic Signature) A T H 0 L 0 Page 2 ot 2 G
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diff --git a/output/text/0aa6302c-8049-4f5a-a0d5-f4a5ada9a5c7.txt b/output/text/0aa6302c-8049-4f5a-a0d5-f4a5ada9a5c7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e2dd1cbe41db1c99c8c2bb86e48aaa38df909612
--- /dev/null
+++ b/output/text/0aa6302c-8049-4f5a-a0d5-f4a5ada9a5c7.txt
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+
+--- Page 1 ---
+UUID:81B3FE6C-B158-4165-9E26-DB95B9D6FC9B ID6-3 tcgA-g7-A8Le-01a-pr Redacted 8QkO3 SPECIMENS: C649  A. LEF TPARTIAL NEPHRECTOMY 24]L3 SPECIMEN(S): A. LEF TPARTIAL NEPHRECTOMY DIAGNOSIS: A. KIDNEY, LEFT, PARTIAL NEPHRECTOMY: - RENAL CELL CARCINOMA, PAPILLARY TYPE - FUHRMAN GRADE: 2 - TUMOR SIZE: 4 x 3.8 x 3 CM - TUMOR LIMITED TO THE KIDNEY - SURGICAL MARGIN FOCALLY POSITIVE (0.1 CM) SYNOPTIC REPORT - KIDNEY (PARTIAL OR RADICAL) Specimens Involved Specimens: A: LEF TPARTIAL NEPHRECTOMY Specimen Type: Partial nephrectomy Without adrenal gland Laterality: Left Tumor Site: Not specified. Focality: Unifocal Tumor Size (largest tumor if multiple): Greatest dimension: 4cm Additional dimensions: 3.8cm x 3cm Macroscopic Extent of Tumor: Tumor limited to kidney WHO CLASSIFICATION Papillary renal cell carcinoma 8260/3 Histologic Grade (Fuhrman Nuclear Grade): G2: Nuclei slightly irregular, approximately 15 u;. nucleoli evident Invasion of Vascular/Lymphatic: Absent Perinephric Tissue Invasion: Absent Margins: Margin(s) involved by invasive carcinoma Include:  Renal parenchymal margin (partial nephrectomy only) Distance: Ocm Adrenal Gland: Not present Regional Lymph Nodes: None sampled Additional Findings: Glomerular disease. type:: GLOMERULOSCLEROSIS Pathological Staging (pTNM):  pT 1a N X M X Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition pMX: Cannot be assessed GROSS DESCRIPTION: A. LEFT PARTIAL NEPHRECTOMY fresh labeled with the patient's identification and designated "left partial nephrectomy" is a ruptured. partial nephrectomy specimen with attached perirenal adipose tissue weighing 31 g and measuring 9.5 x 4 x 3.5 cm. A suture designates the surgical resection margin, inked blue (remainder of the specimen. inked black). The specimen is sectioned to show an ill-defined, soft, 4 x 3.8 x 3 cm mass with. heterogeneous, focally hemorrhagic cut surface approaching the surgical resection margin at 0.1 cm.. The mass grossly involves the surrounding adipose tissue. Gross photograph is taken. A portion of the. specimen is submitted for tissue procurement. Representative sections are submitted: A1-A4: Mass, surgical resection margin A5-A6: Mass, disrupted area. A7-A8: Mass, adipose tissue
+
+--- Page 2 ---
+CLINICAL HISTORY: None Given PrE-OPERATIVe DIAGNOSIS: Left renal mass Gross Dictation:, Microscopic/Diagnostic Dictation: Final Review: Pathologist. Final:., Pathologist,
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diff --git a/output/text/0ab1d375-b16f-491d-a0aa-27ced8b3bb9f.txt b/output/text/0ab1d375-b16f-491d-a0aa-27ced8b3bb9f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..835c0a7542fc337e9d007e465c58fbd971d258d8
--- /dev/null
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+
+--- Page 1 ---
+Diagnosis: Resected colon (sigma) with tumor-free oral and aboral resection margins, with a stalked, tubular adenoma with severe dysplasia (synonymously: profound intraepithelial neoplasia), including a polypoid, moderately differentiated adenocarcinoma with infiltration of the. lamina muscularis propria and not displaying any lymph node metastases in the region (G2,. pT2, L0, V0, R0, pN0 0/46).
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diff --git a/output/text/0abc18ad-d1d4-440f-943b-de183ae56b46.txt b/output/text/0abc18ad-d1d4-440f-943b-de183ae56b46.txt
new file mode 100644
index 0000000000000000000000000000000000000000..045364a82b393d401fbf663dcd8cfe5211f6b1c7
--- /dev/null
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+
+--- Page 1 ---
+1cD-0-3 Cnrcnomn,mfiHtnatnq custal, Nos 85oof3 PaH Sit:3ust,LQ c50,2 CQcF 9th: Qrust,Nos c5o.y Diagnosis: 1. Ablated (right) breast sample with a multifocal invasive ductal carcinoma with intraductal components and focal angioinvasion (focus of a poorly differentiated invasive ductal carcinoma with a tumor diameter of 2.8 cm and two further foci of a moderately invasive ductal carcinoma with tumor diameters of 3.0 cm and 1 cm) Dorsal resection margin tumor-free with minimum margin of 0.5 cm with the first tumor focus, 1.5 cm with the second and 0.7 cm with the third, other margins are free. Tumor classification: NOS, G III, pT2(mult)N3aL1V0R0 UUID: 683AAF99-3B91-4501-B701-C3A4E84396470 Redacted TCGA-A8-A08F-01A-PR
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diff --git a/output/text/0ac9fe17-f322-4ae6-a1f0-3c5de2e33fe4.txt b/output/text/0ac9fe17-f322-4ae6-a1f0-3c5de2e33fe4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..58c276e8f18e418a9dd7bcc81d2bfda3cfdd19b6
--- /dev/null
+++ b/output/text/0ac9fe17-f322-4ae6-a1f0-3c5de2e33fe4.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:7381633C-866A-4440-93B1-BC7102B59C93 TCGA-DD-A4NF-01A-PR Redacted DIAGNOSIS: A. Gallbladder, cholecystectomy: Chronic cholecystitis with cholelithiasis and cholesterolosis. One benign lymph node identified. B. Liver, segment 8, wedge biopsy: Moderately differentiated hepatocellular carcinoma, forming a single 3.2 x 2.9 x 2.8 cm mass. Vascular invasion is not identified. Surgical margins are negative for tumor (closest margin, 0.6 cm). The background liver shows mildly active (grade 2 of 4) chronic hepatitis C with bridging fibrosis and early cirrhosis (stage 3-4 of 6). With available surgical material [AJcc pTl] (7th edition, ADDENDUM: Reticulin and trichrome stains support the above diagnosis. IcD-o-3 'arcinono-, hyoato celulcr Nss 817d/3 Site! Liver  CQQ.D J 1Q/24)1z
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diff --git a/output/text/0ad26dff-97aa-4b21-9ac1-d032b037584c.txt b/output/text/0ad26dff-97aa-4b21-9ac1-d032b037584c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..430205d04ea225e80117355f83b52f0359c8db2a
--- /dev/null
+++ b/output/text/0ad26dff-97aa-4b21-9ac1-d032b037584c.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:5A7EB73F-E681-46CC-B2D6-C87EEAB0AC99 TCGA-AC-A2F0-01A-PR Redacted Collected: Accesslon #: Received: Acct / Reg # Reported: SURGICAL PATHOLOGy REPORt ADDENDUM REPORT ADDENDUM REPORT NUMBER TWO Breast prognostic panel: Biock B2 TEST Criterla RESULT REFERENCE RANGES Diagrosis Discrepan DNA Analysls by Image: Prior Malignancy History Discrepancy  DNA Index: 1.1 (DIPLOID) 0.9 -1.1 Is Diploid < 0.9 or > 1.1 is Aneuplold Case u (circle): QUALIFIED Reviewes initials Her2 Geno Amplificatlon By FISH:  UNABLE TO BE DETERMINEQ W Jw4fiofn Co3]T Average copies per cell:  Her-2/neu: Chromosome 17: Ratio: > 2.0 Her2/neu COmmENT: This specimen falied to hybridize successfully with probes speciflc to Her2/neu gene and chromosome 17 aipha satellite. Soquences. Non formalin and ethanol based fixatives as well as age and storage conditiona of the specimen may contribute to unsuccessfu! FISH analysis. Repeat studies are recommended if additional tissue becomes available from subsequent specimens. Case interpreted by Notes: *Quantitative analysis performed using Chromavislon ACis. Tho Her2 /neu and CEP17 probes are manufactured by * The Hor2/neu gene dotectlon by Fiuoroscence In Situ Hyondization (FiSH) was performed using the LSl Her2/neu DNA probe, specifice for the Her2/neu gene locus. 17q11.2-q12 and the CEP1 DNA probe specific for the alpha satellite DNA sequence at the centromerice  reglon of chromosome 17 (17p11.1-q11.1) These tests woro developed and performance characteristics determined by the  boen cleared or approved by tho Us Food and Drug Administration. The FDA has determined that such approval or ciearance is not. They have not necessary. Those tests are used for clinical purposes. They should not be regarded as investigational or for research. This Iaboratory Is certified under the Clinical Laboratory Improvement Act (CLiA) of 1988 as qualified to perform high complexity clinica). Jaboratory testing. Addendum Report Issued By: ADDENDUM REPORT NUMSER ONE 1cO-0-3 8REAST PROGNOSTiC PANEL: (Prellminary test results on block B2.) carcmona, mfi/tratny TEST RESULT REFERENCE RANGES Estrogen Receptor: Posltive (95%) > 4% is Positive 2-4% I Borderline Sit: brsst Nos c5u.9 < 2% is Negative Progesterone Receptor: Negatiye (0%) > 4% Is Poeitive 2-4% ic Borderlino < 2% Is Negative KI-67 (MiB1) Prolferation Marker: Low (<10%) > 20% Is High 10-20% is Borderline < 10% Is Low
+
+--- Page 2 ---
+These results were interpreted by .  An additlonal addendum report will foilow when DNA and Her-2-neu tests are completed. These tests were developed and performance characteristics determined by  They have not been cleared or approved by tho Us Food and Drug Administration. The FoA has determinod that such approval or clearance is not necessasy. These tests are used for cilnical purposes. They should not be regarded as investigational or for research. This iaboratory is certified under the Clinical Laboratory Improvemont Act (CLiA) of 1988 as qualified to perform high complexity clinical laboratory testingd Addondum Report Issued By DIAGNOSIS DIAGNOSIS: A,B,C: Laft mastectony with ieft sentinel iymph node and additional lymph node for dlagnosis of breast carcinoma:. Tumor Characteristics: 1. Histologic typo: Innttrating lobular carcinomas 2. Size: 2.5 x 2 x 1.8 cm. 3. Elston modifilcation of Bloom-Richardson grade:. a. Archltoctural Score:3/3. b. Nuclear Score: 2/3. C. Mitotic Score: 1/3. d.Total score: 6/9 - Grade: II. 4. In-situ component: Present. e. Amount: Less then 25%. f. Histologlc type: Lobular carcInoma in situ. g.Architectural typo: Solld. h. Nuclear grade: I. Comedo necrosis: Absent. 5. Margin status for in situ carcInoma: Not transected. 6. Lymphovascular space invaslon: No. 7. Skin Involvement: No. 8.  Are microcalcificatlons identifiod in assoclation with tumor: No. Surgical Margin Status: Is tumor transected: No. 2. Tumor distance to closest margin: 1.5 cm deep margin. Lymph Node Status: Total number of lymph nodes oxamined: Ten.. Total number of lymph nodes containing metastatlc carcinoma by gross exam or light mlcroscopy: Sentinel, 1/2; Level I and l, 1/8. 3. Size of iargest metastasis: 9 mm. 4. Extra-capsuiar extenslon of tumor: No. Other: Other significant findings: Flbrocystic chang. with epithellat hyperplasia and benlgn calcifications.  Block prognostic indicators will be obtained on paraffin block B2. 3. Correlatiowstatement with intra-op consult or frozen sectlon: Frozen section dlagnosls sentinel lymph Is confirmed by permanent. section nalysis. 4. .pTNM st go: T2N1MX. 5. It further t Unyts required In the future, inflitrating carcinoma Is best seen In blocks B2,3,4 and 5.
+
+--- Page 3 ---
+DIAGNOSIS D. Skin, lip, blopsy: Benign solar lentigo (pigmentod actinlc keratosis). Electronic Signature: CLINICAL INFORMATION CLINICAL HISTORy: Preoperative Diagnosis: Lef breast cancer Postoperative Diagnosis: Symptoms/Radiologic Findings:e SPECIMENS: A. Left sentinel lymph node FS. B. Left breast tissue C. Left lymph nodes D. Seborrhelc keratosis of lip. Gross DescrIpTIon: A. Container A is labalod.. .r, A and consisls of a tan-yellow firm fatty nodule, 2.0 x 1.0 x 1.0 cm in greatest dimension. The specimen is trisected  and entirety submitted for frozen section in one cassette labeled 8. Container B is labeled r, B and consists of a 255 gram portion of lent breast tissue, 14.0 x 11.0 x 6.0 cn with attached tan-gray ellipso of skin. 5.0 x 4.2 cm displaying a centrally located fiattened nipple, 0.8 cm in greatest dimension. The doep margin Is inked and the specimen is sectioned to reveal predominately tan-yellow lobular adlpose tissue intermixed with moderate amounts of tan-gray dense fibrous tissue. A gray-white stellate gritty  mass is notod in the upper outer quadrant and is 2.5 x 2.0 x 1.8 cm in greatest dimension. Samples of this mass have been submitted for genomic Studies. This mass is located 2.0 cm fron tho skin surface and 1.5 cm from the deep margin. No other leslons are grossty noted. The lateral margin  displays a gray-white minute nodule possibly representing lymph node, 0.2 cm. Representative sections submitted in elavan cassettes I as follows: nlpple--1; stellate mass-2 to 5; deep margin--6; upper inner quadrant--7; upper outer-8; iower inner-9; lower outer--10; latera) C. Container C is labeled* I consists of a tan-yellow lobular mass of adipose tissue, 11.0 x 4.0 x 2.0 cm in greatest dimension. Sectioning  reveals elght tan-yellow firm fatty nodules, the largest t.5 cm. Samples of these nodules submitted in four cassettes labeled t. D. Contalner D is labeled  D and consists of a tan-gray granular ralsed lesion, 0.5 x 0.3 x 0.2 cm. The skin surface displays a mottled dark brown discoloration. The specimen is inked, seriaily sectioned and entirely submitted In one cassette labeied 1
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diff --git a/output/text/0afaec00-22c0-41a5-8886-45a0db3dc1e9.txt b/output/text/0afaec00-22c0-41a5-8886-45a0db3dc1e9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..054c0b9d5c5ab28c90ba3a931348406e96d5c45c
--- /dev/null
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+
+--- Page 1 ---
+Surgical Pathology Report Name: Case #: DOb: Collected: Gender: M Received: MRN: Reported: Locatlon: Copy To: Physiclan: Pathologic Interpretatlon: 1cD-0-3 Casiioma, mnf/tutwg ductl nos 85oo/3 A. SENTINEL NODE #1 COUNT Sit: breaot, Nos C50.9 3// f - meTASTaTIC CARciNOmA tO ONe Lymph nODe (1/1). 8. SENTINEL NODE #2 COUNT - metastatIc CARcinoma tO One Lymph nODe (1/1). C. RIGHT TOTAL MASTECTOMy: - iNFILTRATiNG DUCTAL CARCINOMA, NOTTINGHAM GRADE 2 (3+2+2=7), 1.6 CM IN GREATEST Dimension. - RESECTION MARGINS ARE FREE OF TUMOR, CLOSEST MARGiN AT 2.0 CM (DEEP) - PREDICTIVE MARKERS PERFORMED ON PREVIOUS BIOPSY: ER AND PR POSITIVE BY IMMUNOHISTOCHEMiSTRY AND HER2 AMPLIFiED BY FISH. - NO MALIGNANCY SEEN IN FIVE LYMPH NODES (0/5). - PLEASE SEe TUMOR SUMmARY. AJCC: pT1c, pN1a, pMn/a Tumor Summary: UUID:B6D80CA9-F4DA-4DFB-80BF-088EE17142BD Redacted TCGA-EW-A1PD-01A-PR Specimen: - Total breast (including nipple and skin) Procedure: - Total mastectomy (including nipple and skin) Lymph Node Sampling:. - Sentinel lymph node(s) - Axillary dilssection (partial or complete dissection). Specimen Integrity: - Single intact specimen (margins can be evaluated) Specimen Laterality: - Right Tumor Site: Invasive Carcinoma - Central Tumor Slze: Size of Largest Invasive CarcInoma. - Greatest dimension of largest focus of invasion over 0.1 cm: 1.6 cm Tumor Focallty: - Single focus of invasive carcinoma. Macroscopic and Microscopic Extent of tumor:. - Skin: Invasive carcinoma does not invade into the dermls or epidermis - Nippte: DCIS does not involve the nipple epidermls - Skeletal muscle: No skeletal muscle present Ductal Carcinoma In (DCIS): - DCIS is present Size (Extent) of DCIS: *Estimated size (extent) of DCiS (greatest dimension using gross and microscopic evaluation) is at least: 0.5 cm Number of blocks with DCis: 5 Number of blocks examined: 10 - Architectural Patterns: Cribriform, Solid - Nuclear Grade:Grade III (high) - Necrosis: Present, focal (small foci or single cell necrosis) Lobular Carcinoma In Situ: Not identified Histologlc Type: - Invasive ductal carcinoma (no special type or not otherwise specified)
+
+--- Page 2 ---
+SURGICAL PATHOL Report Histologlc Grade: Nottingham Histologic Score Glandular (Acinar)/Tubular Differentiation:  Score 3 Nuclear Pleomorphism: Score 2: Mitotic Count: Score 2 Overall Grade: Grade 2: scores of 6 or 7 Margins: - Margins uninvoived by invasive carcinoma -Distance from closest margin: 20 mm (deep) Lymph-Vascular Invaslon: Not identified. Lymph Nodes: Number of sentinel lymph nodes examined: 2 Total number of lymph nodes examined (sentinel and nonsentinel): 7 Number of lymph nodes with macrometastases (>0.2 cm): 2 Number of lymph nodes with macrometastases (>0.2 mm to 0.2 cm and/or >200 cells): 0 *Size of largest metastatic deposit (if present): 1.5 cm Extranodal Extension: Indeterminate *Method of Evaluation of Sentinel Lymph Nodes: - H&E, multiple levels Pathologic Staging: Primary Tumor: pT1c: Tumor >10 mm but 20 mm in greatest dimension Regional Lymph Nodes: pN1a: Metastases in 1 to 3 axillary lymph nodes, at least 1 metastasls greater than 2.0 mm Distant Metastasis: Not appticable MIcrocalciflcatlons: PRESENT in DCIS Anclllary Studies: Estrogen Receptor: ):Results: Immunoreactive tumor cells present (1 %) - Performed on another specimen  Progesterone Receptor: - Performed on another specimen ! : Results: Immunoreactive tumor cells present (1 %) Her2: - Performed on another specimen :Results: Equivocal (Score 2+) HER2 by FISH: - Performed on another specimen ! j:Results: AMPLIFIED (HER2 gene copy >6.0 or ratio >2.2) NOrE: Some immurohistochemical antibodies . s are analyte sperific reagents (ASRs) valldoted by our laboroiory. These ASRs are ctinically useful indirators thot do nos require FD4 apprornl. These clones are used: 1D5-5R PgR 636-PR, A43s=HER2, i-11-EGFR. Allimmwohistochemica sains are used wih formalin or molecular Sixed, purufin embedded tissue. Detccton is by Emision Method. The resulis are read by a pathologist as positive or negative. As the attending pathologist, I attest that I: (i) Examined the relevant preparation(s) for the specinen(s); and (ii) Rendered the diagnosis(es).  MD ***Electronically Signed Out By*** Intraoperative Consultation Sentinel node #1 count : FS:  Metastatic carcinoma seen on touch prep A. B. Sentinel node #2 count FS: Metastatic carcinoma seen on touch prep : MD MD Clinical History: None provided Operatlon Performed Page 2 of 3
+
+--- Page 3 ---
+SURGICAL PATHOL Report Right total mastectomy with axillary node dissection and sentinel node biopsy Pre Operative Dlagnosis:. Breast ductal carcinoma Specimen(s) Recelved: A: Sentinel node #1 count B: Sentinel node #2 count 1,FS C: Right total mastectomy. Gross Description: A. Received fresh is a segment of tan-brown fibroadipose tlssue, 1.8 x 1.5 x 0.7 cm.The specimen is bisected and submitted in toto in two blocks.. B. Received in formalin is a segment of tan-gray soft tissue, 1 x 0.9 x 0.6 cm. The specimen is bisected and submitted in toto in one block. C. Received in formalin is a 447-gram, 18 x 17.5 x 2 cm right mastectomy specimen. There is an ellipse of pale skin, 14.2 x 6.1 cm. The nipple/areola complex measures 2.5 x 2 cm. The nipple is retracted. The attached axillary tail measures 11.5 x 6.5 cm. The specimen is oriented with short stitch superior, two long stitches lateral. The resection margins are inked black. On serial sectioning, there is a tan-white, indurated, ill-defined lesion with infiltrating borders in the retroareolar space. it occupies the central compartment and measures 3 x 1.5 x 1.5 cm. It is located 2 cm from the deep  margin, 7.5 cm from the inferior margin, 5 cm from the superior margin, 7 cm from the medial margin, and 9 cm from the  Iateral margin. No addltlonal lesions are identified. Examination of the axillary tail reveals multiple possib!e. lymph nodes.. Sections are submitted as follows: 1 Nipple 2 Deep margin (closest) 3-9 Lesion submitted in toto 10-12 One lymph node per block 13&14 Three lymph nodes per block. f+x/n Page 3 of 3
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diff --git a/output/text/0afe2418-949c-4452-bdad-906c07974b49.txt b/output/text/0afe2418-949c-4452-bdad-906c07974b49.txt
new file mode 100644
index 0000000000000000000000000000000000000000..bfed64e49709868385acc6b82f8bd74f913c4d90
--- /dev/null
+++ b/output/text/0afe2418-949c-4452-bdad-906c07974b49.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+ICDO UUID:73018C2B-3F93-4CD8-B2F7-4054EDB518AB TCGA-B9-A8YH-01A-PR Redacted feopllaiy sna sucsnonrs y SURGICAL PATHOLOGY cesC  s2co/3 Case Number : 90s6/3 St B%ioluuy No5 Diagnosis: A: Kidney, right, robotic partial nephrectomy. C64.9 QO 4/1h4 Laterality: right Histologic tumor type/subtype: papillary carcinoma, type I. Sarcomatoid features: absent. Histologic grade (if applicable): grade 2 (Fuhrman). Tumor size (greatest dimension): 3.0 x 2.7 x 2.0 cm Tumor focality: unifocal Extent of tumor invasion (if present specify if macroscopic or microscopic): Capsular invasion/perirenal adipose tissue: not identified. Gerota' s fascia: not identified Renal sinus: not applicable Lymphatic (small vessel): not identified Histologic assessment of surgical margins:. Renal parenchymal margin (partial nephrectomy only): negative for malignancy Renal capsular margin (partial nephrectomy only): negative for. malignancy Paranephric adipose tissue margin (partial nephrectomy only): negative for malignancy AJcc Staging: pT1a pNx This staging information is based on information available at the time of this report, and is subject to change pending. clinical review and additional information.. Clinical History: -year-old male with right renal mass..
+
+--- Page 2 ---
+Gross Description: Received is one appropriately labeled container, additionally labeled "right renal mass" and consists of a 13 gram (3.1 x 2.9 x 2.7 cm) partial nephrectomy. The capsule is intact pink/tan, smooth with a scant amount of attached adipose tissue. The capsule is inked blue and the parenchymal margin is inked black. The cut surface has a 3.0 x 2.7 x 2.0 cm well-circumscribed soft variegated mass that bulges the capsule but does not extend through it and grossly abuts the parenchymal margin. The mass occupies approximately 90% of the specimen and approximately 10% hemorrhage and necrosis. A portion of the mass is given to tumor procurement foundation. A perpendicular section with respect to the capsule and parenchymal margin in Al-A5.. PuU TSS dx discrparty fom.TC6A tumur is phpi lsry rerel ell earceiom 1/30iy
+
+--- Page 3 ---
+TCGA Pathologie Diagnosis Diserepancy Form Instructions: The TcGA Pathologic Diagnosis Discrepancy Form should be completed when the pathologic diagnosis. documented on the initial pathology report for a case submitted for TcGA is inconsistent with the diognosia provided on the Case Quality Control Form completed for the submitted case. Tissue Source Site (TSS): TSS Identifier: TSs Unique Patient Identitier? Completed By (Interviewer Name on OpenClinica): Completed Date: Diagnosis Information  Data Element Entry Alternatives Working Instr uc tions. Provide the diagnosis/ histologie suhtype(s) doeumented am Pathologic Diagnosis the iowial patholowy report for this case, Jr the hiswlogy lor papillary carcinona. lype I Provided on Initial this case is mixed, providle all ligtnd subt ypes. Pathology Report Provide the histologht Jeatureg selet ted on the TcGA tace Histologic features of Quality Control Vorm completed for this case. the sample provided Kidney papillary renal cell carcinoma for TCGA, as reflected on the CQCF. Discrepancy between Pathology Report and Case Quality Control Form. . Provide the reason for The tissue sample was taken at resection Provide a reason dese ribing why the diagnosis on the Jnitia!  the discrepancy. pathology report for this case is not consistant with the from a R kidney robotic partial nephrectormy diagnosis selected on the IcGA Caze Quality Control Vorm. between the pathology with the reading pathologist stating the dx as report and the TCGA only "papillary carcinoma, type I" and having Case Quality Control Fuhrman grade 2 rather than specifying it as Form. a renal cell carcinoma, papillary lype. Subsequently the treating MD states the dx as "papillary type 1 renal cell carcinoma in the right kidney" Name of TSS Reviewing Provide the name ol the pathologist who reviewed ths case fOrTCGA. Pathologist or. Biorepository Director I acknowledge that the abave informauon provided hy my institution is true and correct and has been quallty controlled.. TSS Revlewing Pathologist or Biorepository Director Date I acknowiedge that the above Informatson provided by my institutlon Is true and. Department Chalrman has been Informed or is aware of the above dixcrepancy in dlognoxes..  Princrpal Investigator Signature  Date
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diff --git a/output/text/0b09e9e6-535f-423e-a36c-80e76e7bba97.txt b/output/text/0b09e9e6-535f-423e-a36c-80e76e7bba97.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1b83b51ea31eb1552adeb3b5d6e227a37ec4ac58
--- /dev/null
+++ b/output/text/0b09e9e6-535f-423e-a36c-80e76e7bba97.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:08519263-5ADD-48A3-98C6-C737ACA7DFE4 TCGA-AN-A0G0-01A-PR Redacted TSS Patient ID: Case #: . DOB: Sex: Female Ethnicity (Race): Cancer Sample Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma Date of Procurement Anatomic Site: Right Breast Tumor location: Primary. Tissue Specification: Tumor Specinen Matrix: Tissue Specimen Format: Frozen Container: cryomold Type of Procurement: Radical mastectomy Grade: 3. T Stage: 2 N Stage: 0 M Stage: 0 Treatment: none. Treatment Details: n/a Normal Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw Matrix: Blood Specimen Format: frozen Container: tubee Date of Procurement: : ICs-0-3 csvcionu, infiHrstnq duct,No5 85oc/3 Sit: breast, Nos C50.9 hw 10/21/4 10/p/+r)
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diff --git a/output/text/0b1bb313-f682-4657-9092-caf2d716dd55.txt b/output/text/0b1bb313-f682-4657-9092-caf2d716dd55.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1396de83ffe63e61dd737072d6da436e0d19e300
--- /dev/null
+++ b/output/text/0b1bb313-f682-4657-9092-caf2d716dd55.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+QC Pathologist TCGA-AD-6548 FINAL PATHOLOGIC DIAGNOSIS Right colectomy with attached portion of terminal ileum: Two carcinomas of colon. Tumor Characteristics: 1.Histologic type for both: Adenocarcinoma. 2.Histologic grade for both Moderately differentiated. 3.Tumor site for both: Splenic flexure area. 4.Tumor size:Largest2.9x2.6 x0.5 cmsmallest 1.6 x1.4x0.3cm. 5.Lymphovascular space invasion:Not identified 6.Microscopic tumor extension: a.Largest tumor exhibits invasion not quite completely through the muscularis propria. b.Smallest tumor does not invade muscularis propria, 7.Treatment effect None identified. Surgical Margin Status: 1.Proximal margin nearest to largest tumor14.3 cm. 2.Distal margin nearest to smaller tumor Approximately 4.0cm. 3.Circumferential (radial margin which is closest to largest tumor.0.4 cm. 4.Distance of tumor from closest margin0.4 cm. Lymph Node Status: 1.Total number of lymph nodes received12. 2.Total number of lymph nodes containing metastatic carcinoma:None (0/12). Other: 1.Other significant findings:A separate tubular adenoma without high grade dysplasia is noted. 2.pTNM stage:pT2,NOlargest tumor.pT1,NO smallest tumor). COMMENTS: CLINICAL HISTORY: Preoperative Diagnosis Postoperative Diagnosis Symptoms/Radiologic Findings: SPECIMENS:
+
+--- Page 2 ---
+Right colon CGA-AD-6548 GROSS DESCRIPTION: Received in formalin and labeled and#1 right colon is an 18.1 cm segment of previously opened colon with an attached 2.6 cm segment of small bowel, a moderate amount of pericolic fat,and a 16.6 x 5.3 x 0.7 cm portion of omentum.The appendix is not present. The serosa is smooth and tan-pink.There is a 2.9 x2.6 cm granular tan-pink mucosal mass with raised borders,5.8 cm, 7.9 cm and 14.3 cm from the distal margin ileocecal valve, and proximal margins,respectively.The cut surface of the mass is gray-white and appears to extend into the muscularis to a depth of 0.2 cm.The mass does not grossly appear to involve the pericolic fat. At 1.3 cm distal to the mass,is a 1.6 x 1.4 cmtan mucosal polyp,4.1 cm from the distal margin. The polyp does not appear to extend into the underlying muscularis. The remainder of the mucosa is tan with the normal foids, with a 1.3 x 0.6 cmill-defined,firmtan nodule in the cecal pouch.No additional obvious mucosal lesions are identified. The proximal and distal inner circumferences average 4.5 cm and 3.8 cm.respectively,and the wall thickness averages 0.3 cm.There are multiple irregular,tan-yellow firm tissues consistent with probable lymph node,ranging from 0.2x0.2x0.1cm to0.7x0.5x0.4cm. The specimen is inked,sectioned,and representative sections are submitted as labeled:1.proximal and distal margins2,ileocecal valve;3 and 4,mass to inked serosa perpendicular)5,mass to uninvolved mucosa6 and 7 mass8-11,mucosal polyp.entirely submitted12,nodule in cecum,entirely submitted13,omentum14-16,five whole possible lymph nodes in each17 and 18,three whole probable lymph nodes in each.The blocks are labeled Also received in the same container are green yellow and blue cassettes labeled for genomic research study. 1 or more Final Results Received
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diff --git a/output/text/0b2a99c6-979d-4be2-926c-c95db35eb4a0.txt b/output/text/0b2a99c6-979d-4be2-926c-c95db35eb4a0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..63161c1b36da262c396d98485963b6ae67b83594
--- /dev/null
+++ b/output/text/0b2a99c6-979d-4be2-926c-c95db35eb4a0.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+FINAL DIAGNOSIS: Part 1: Left AxillA, Sentinel Lymph node #1, BiOpsy - Jcs-0-3 One lymph node, negative for tumor.. Carciona, nifiltnutry ductal, nos 850|3 Part 2: Left axilLA, sentinel Lymph node #2, biOpsy -- Sih: brast,nrs C50,9 One lymph node, negative for tumor. 3|13fn ww Part 3: Left axillA, nOn-Sentinel Lymph node, BiOpsy -- ONE LyMPH NODE, NEGATIVE fOR TUMOR. Part 4: Leet Breast, Segmental mAstectomy wIth neeDLe LOcaLizatIOn --  INFILTRATING DUCTAL CARCINOMA.,1.1 CM, NOTTInGHAm SCORE 6/9 (TUBULES 3, NUCLEI 2, MITOSIS 1). B. DUCTAL CARCINOMA iN-SITU, CRIBRIFORM AND SOLID TYPES, WITH COMEDO NECROSIS REPRESENTiNG 10% OF THE TUMOR VOLUME. C. FOCI OF DCIS IS SEEN AWAY FROM THE INVASIVE TUMOR. D.  LYMPHOVASCULAR SPACE INVOLVEMENT IS NOT PROMINENT. E.  INVASIVE TUMOR IS 0.4 CM FROM THE INFERIOR MARGIN. F. DUCTAL CARCINOMA iN-SITU, 0.2 CM FROM THE INFERIOR MARGIN. G.  MARGINS FREE OF TUMOR. H. MICROCALCIFICATIONS ASSOCIATED WITH TUMOR AND BENIGN CHANGES. FIBROCYSTiC CHANGES. J.  SKIN UNREMARKABLE. CASE SYNOPSIS: SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST LATERALITY: Left Procedure: Segmental LOCATION: Lower inner quadrant SiZE Of TumOR: Maximum dimension invasive component: 1.1 cm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: No TUMOR TYPE (invasive component): Ductal adenocarcinoma, NOS NOTTInGhAm SCORe: Nuclear grade: 2 Tubule formation: 3 Mitotic activity score: 1 Total Nottingham score: 6 UUID:6122CE59-23C0-4205-91B5-B71E39C6EAB8 Nottingham grade (1, 2, 3): 2 TCGA-BH-A0BR-01A-PR Redacted ANGIOLYMPHATiC iNVASION: No DERMAL LYMPHATIC INVASION: No CALCIFICATION: Yes, benign zones Yes, malignant zones Tumor type, in situ: Cribriform Solid Comedo Percent of tumor occupied by in situ component: 10 % SURGICAL MARGINS iNVOLVED BY iNVASIVE COMPONENT: No Distance of invasive tumor to closest margin: 4 mm. SURG MARGINS INVOLVED BY IN SITU COMPONENT:E No Distance of in situ disease to closest margin: 2 mm Lymph nOdes pOsitive: LYMPH NODES EXAMINED: 3 MethOD(S) Of Lymph NODE EXAminATiOn:  H/E stain SENTINEL NODE METASTASIS: No SKIN INVOLVED (ULCERATION): No NON-NEOPLASTIC BREAST TISSUE: FCD t stage, pathologiC: pT1c N Stage, pathologIC: pN0 m Stage, pathologiC: pMX ESTROGEN RECEPTORS: positive PROGESTERONE RECEPTORS: positive HER2/NEU: zero or 1+
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diff --git a/output/text/0b40c583-d5b8-4a18-906e-eaf50176f9c1.txt b/output/text/0b40c583-d5b8-4a18-906e-eaf50176f9c1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..afb3fa29638043371a283f7f10da896d6a210948
--- /dev/null
+++ b/output/text/0b40c583-d5b8-4a18-906e-eaf50176f9c1.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+Patient Name: Accession #: Med. Rec. #: Date of Procedure: DOB: Dale of Receipt: Gender: Date of Original Rep Date of Anendment Ret. Physician: Account#: Patient Address: Billing Type: dditional Copy to Ret. Source: Dini Daanosis & History: With large left sided abdominal mass involving left kidney/spleen/colon.. Specimens Suhmitt. 1: SP: l.eft kidney 2: SP: Loft tube and o 3: SP: Rt. tube & ovan 4: SP: $pleer AMENDED DIAGNOSIS: 1) KIDNEY, LEFT, NEPHRECTOMY: - RENAL CELL CARCINOMA, PAPILLARY TYPE WITH EXTENSIVE ONCOCYTIC (OXYPHILIC) CYTOLOGIC FEATURES. . THE TUMOR GREATEST DIAMETER IS 13.0 CM. - THE TUMOR EXTENDS THROUGH THE RENAL CAPSULE BUT IS CONFINED WITHIN GEROTA'S FASCIA + ALL SURGICAL MARGINS ARE FREE OF TUMOR. - THE NON-NEOPLASTIC KIDNEY IS UNREMARKABLE . THE ADRENAL GLAND IS UNREMARKABLE AND NOT INVOLVED BY TUMOR. 2) FALLOPIAN TUBE AND OVARY, LEFT, RESECTION: - UNREMARKABLE OVARY AND FALLOPIAN TUBE WITH PARATUBAL CYSTS 3) FALLOPIAN TUBE AND OVARY, RIGHT, RESECTION: - UNREMARKABLE OVARY AND FALLOPIAN TUBE WITH PARATUBAL CYSTS. 4) SPLEEN, SPLENECTOMY: - SPLEEN WITH HEMORRHAGIC AND NON-CASEATING GRANULOMAS. - NO TUMOR SEEN. Note: This document represents an anended version of the surgical pathology report originally issued on That report. although, retained in the clinical chart for record purposes, is superseded by the present document. The amendment consists Of the following change: ORIGINAL REPORT: Gross Description. Part 1 The specimen is inked and on cut section it reveals the kidney to be replacad almist entirely by multiple nodules of tan-yellow, partially cystic tumor occupying the whole kidney, measuring approximately 13.0 x 9.0 x 6.0 cm. The tumor grossly appears to bo confined to the renal capsule. The tunor surface show fine papillary fronts. TPS is submitled. Photographs taken. Representative seclions are submitted. AMENDED REPORT: Page 1 0f 4
+
+--- Page 2 ---
+Gross Description:. Part 1 The specimen is inked and on cut section it reveals the kidney to be replaced almost entirely by mulipie nodules of tan-yellow. partialy cystic, hemorrhagic tumor occupying the whole kidney, measuring approximately 13.0 x 9.0 x 6.0 cm. Tho tumor grossly abuts the adrenal gland (6.0 x 2.0 x 1.5 cm). The tumor grossly appears to be confined to the renal capsule. The tumor surface show line papillary fronts. TPS is submitled. Photographs taken. Representative sections are submilled. add on: Summary of Sections: ATA -- Additional tumor with adrenal sections. The responsible clinician has been notified. 1ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON AIY PERSONAL EXAMINATION OF THE SLIDES (ANDIOR OTHER MATERIAL). AND THAT I RAVE REVIEWED AND APPROVEO THIS REPORT. Specia! Studies:. Result Special Stain Comment RECUT RECUT RECUT RECUT 1) The specimen is received fresh for frozen section dlagnosis, labeled, "Left kidney". It consists of a 1190 grams.  nephrectomy specimen( 23.0 x 13.0 x 9.0 cm) with altached segment of ureter (1.5 cm in length and 0.4 cm in diameter), and seyment of renal vein (3.0 cm in length and 0.3 cm in diamete)r. The perirenal fat is minimal. The specimen is inked and on cut section it reveals the kidney to be replaced almost ontirely by multiple nodules of tan-yellow, partially cystic, hemorrhagic tumor occupying the whole kidney. measuring approximately 13.0 x 9.0 x 6.0 cm. The tumor grossly abuts the adrenal gland (6.0 x 2.0 x 1.5 cm). The tumor grossly appears to be confined to the renal capsule. The tumor surlace show fine papillary fronts.. TPS is submitted. Pholographs laken. Representalive sections are submitted.. Summary of Sectlons: F$C - frozen section control  UV - ureteral and vascular margin TC - tumor section with the capsule C - cystic areas of the tumor TRP - tunor with the adjacent renal parenchyma. ATA - Additlonal tumor with adrenal sections. 2). The specimen is received fresh for frozen section consultation labeled, "Left tube and ovary" and consists a segment of fallopian tube with fimbriated end measuring 4.8 cm in length x 0.3 cm in diameter.  The serosa is tan-pink, smooth and unremarkable. The fallopian tube is serially cross-sectioned to reveal unremarkable cut surface with a 0.1 cm lumen. There are numerous paratubal cysts identified ranging in size from 0.1 to 0.8 cm in greatest dimension.  The attached ovary is tan-white, smooth and firm. Cut surface is unremarkable and except for  numerous corpora albicantia. Representative sections are submitted for frozen and permanent sections. Summary of sections: Page 2 of 4
+
+--- Page 3 ---
+FSC-frozen section control LTO-left tube and ovary. representative sections 3). The specimen is received in fresh for frozen section consultation labeled, "Right tube and ovary" and consists a segment of fallopian tube with fimbriated end measuring 6.5 cm in length by a 0.4 cm in diameter.  The serosa is tan-pink and smooth with some minute paratubal cysts each measuring less than O.1 cm in diameter. The fallopian tube is serially cross-sectioned to reveal unremarkable cut surface with a 0.1 cm lumen. The attached ovary measures 2 x 2 x 1.5 cm.External surface is tan-white with a 1 x 0.8 x 0.3 cm cyst.The external surtace is inked in blue. Cut surface is light tan, unremarkable. Corpora albicantia are identified. Representative sections are submitted for frozen and permanent sections. Summary of sections: FSC-frozen section control RTO-right tube and ovary, representative sections 4) The specimen is received fresh, labeled, *Spleon'. It consists of a 120 grams spleen (11.0 x 7.0 x 5.0 cm). The hilum. reveals no lymph nodes. The capsule appears to be partially eroded with hemorrhagic surfaceit. Cul sections reveal a 4.5 cm i  triangular nfarction. The remaining spleen parenchyma appears unremarkable. Representative sections are submitted. Summary of Sections: H - hilum section IF -- infarction area C - capsular surlace  U  unremarkable parenchyma Summary of Sections. Part 1: SP:Left kidney Block Soct. Site pCs 5 ATA 5 5 c 1 F$C 1 6 TC 6 5 TRP 5 1 UV 3 Part 2: SP: Left tube and ovary Block Sect. Site PCs 1 FSC 1 1 LTO 4 Part 3: SP: Rt. tube & ovary Block Sect. Site PCs 1 F$C 1 1 RTO 4 Part 4: SP: Spleen 8lock Sect. Site. PCs 1 c 1 H 1 1 U Page 3 of 4
+
+--- Page 4 ---
+Amendments Original Diagnosis: 1) KIDNEY, LEFT. NEPHRECTOMY: - RENAL CELL CARCINOMA, PAPILLARY TYPE WITH EXTENSIVE ONCOCYTIC (OXYPHILIC) CYTOLOGIC FEATURES. : THE TUMOR GREATEST DIAMETER IS 13.0 CM. - THE TUMOR EXTENDS THROUGH THE RENAL CAPSULE BUT IS CONFINED WITHIN GEROTA'S FASCIA. - ALL. SURGICAL MARGINS ARE FREE OF TUMOR. - THE NON-NEOPLASTIC KIDNEY IS UNREMARKABLE. - THE ADRENAL GLAND IS NOT SUBMITTED. 2) FALLOPIAN TUBE AND OVARY, LEFT, RESECTION:  - UNREMARKABLE OVARY AND FALLOPIAN TUBE WITH PARATUBAL CYSTS 3) FALLOPIAN TUBE AND OVARY, RIGHT, RESECTION: - UNREMARKABLE OVARY AND FALLOPIAN TUBE WITH PARATUBAL CYSTS 4) SPLEEN, SPLENECTOMY: - SPLEEN WITH HEMORRHAGIC AND NON-CASEATING GRANULOMAS. - NO TUMOR SEEN. Intraoperative Consuttation: Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS: RENAL CORTICAL CARCINOMA PERMANENT DIAGNOSIS: SEE FINAL 2) FROZEN SECTION DIAGNOSIS: PARATUBAL. CYST. PERMANENT DIAGNOSIS: SAME. 3) FROZEN SECTION DIAGNOSIS: BENIGN PERMANENT DIAGNOSIS: SAME. Page 4 of 4 END OF REPORT
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diff --git a/output/text/0b6dcf0e-3aad-4f3e-a070-70793bc02db0.txt b/output/text/0b6dcf0e-3aad-4f3e-a070-70793bc02db0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..29c6b27d9e7c2093eb9b7bdf581ca39234ceaea6
--- /dev/null
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+
+--- Page 1 ---
+tDo -3 Oidnseurc runs/$O 8 81403 SURGICAL PATHOLOGY lolentearsnwns in Case Number : thbulovesloe odnorn. 8 Qb3/3 Site Cecn C18.D Diagnosis: A: Colon, right, laparoscopic colectomy M ?//13 Tumor Histologic Type: colorectal adenocarcinoma arising in conjunction with tubulovillous adenoma with high grade dysplasia. Histologic Grade: moderately differentiated. Tumor Location: cecal pouch. UID:32360E38-C269-487F-806F-A3880DE9F3E LX-01A-PR Redacted Depth of Invasion: -Into but not through muscularis propria Lymphovascular Invasion: not identified Perineural Invasion: not identified Margins: Proximal margin: negative for malignancy; tumor is 5.2 cm from proximal margin (gross measurement) Distal margin: negative for malignancy; tumor is 14.6 cm from. the distal margin (gross measurement) Mesenteric margin: negative for malignancy; tumor is 5.9 cm from the mesenteric margin (gross measurement) Distance of carcinoma from closest margin (specify): 5.2 cm, proximal margin. Regional Lymph Nodes: 28 lymph nodes, negative for malignancy (0/28) Additional Pathologic Findings:. - Tubulovillous adenoma separate from tumor, 2.7 cm in greatest dimension with focal high grade dysplasia - Appendix with acute serositis. AJcc Pathologic TNM Stage: pT2 pNO Note: This pathologic stage assessment is based on information available at the time of this report, and is subject to change pending clinical review and additional information..
+
+--- Page 2 ---
+Clinical History: -year-old female with right colon cancer. Gross Description:. Specimen A is labeled "right colon". Specimen fixation: Formalin Parts of bowel received: Terminal ileum (4.1 cm long x 3.3 cm in circumference), ascending colon (14.7 cm long x 5.7 cm in. circumference), vermiform appendix (8.1 cm long x 0.6 cm in diameter) and attached mesentery (22.3 x 8.2 x 3.4 cm). Measurement: Please see parts of bowel received. Specimen integrity: Intact Orientation: Inking: serosa overlying the cecal mass/blue, mesenteric margin/green Tumor location: Cecal pouch Gross appearance of tumor: Filling the cecal pouch is a tan/brown firm exophytic mass with well-defined rolled nodular borders. Also within the cecal pouch adjacent to the mass but not communicating with it is a soft tan/brown sessile polypoid polyp. Tumor dimensions: The mass is 5.3 x 4.1 x 1.7 cm (protruding into the lumina) and the polyp is 2.7 x 2.3 x 1.7 cm. Bowel circumference at tumor site: 7.7 cm Circumferential growth: Mass and polyp occupy the entire cecal pouch and adjacent luminal circumference involved is approximately 60%. Gross depth of invasion: The mass extends 0.9 cm through the muscularis propria, into the mesentery and grossly retracts the serosa, but does not extend through it. The polyp is confined to the mucosal surface.. Gross evidence of perforation through visceral peritoneum: No Luminal obstruction: The cecal pouch portion of the lumen is completely obstructed, but the ascending colon lumen just distal to the mass is patent.
+
+--- Page 3 ---
+Gross distance of tumor from margins: The mass is 5.2 cm from the proximal mucosal margin, 14.6 cm from the distal mucosal. margin, and 5.9 cm from the mesenteric margin. The polyp is 8.6 cm from the proximal margin, 14.9 cm from the distal mucosal margin, and 8.1 cm from the mesenteric margin Other remarkable findings: The appendix is intact, curved and adherent within the mesentery. The serosa is purple/tan, smooth and glistening. The lumen is pinpoint with a tan mucosa. The appendix is uninvolved by mass and the mass is 1.8 cm from the appendical orifice. Lymph nodes: Multiple lymph node candidates are identified ranging from 0.2 cm in greatest dimension up to 1.5 x 1.0 x 0.9 cm in greatest dimension. Tissue submitted for special investigation: Tumor and normal are given to tumor procurement foundation. Digital photograph taken: No Block Summary: Al - Proximal mucosal margin, en face A2-A3 - Distal mucosal margin, en face A4 - Mesenteric margin, en face A5 - Appendiceal orifice A5-A9 - Sections of mass, A6 and A7 are deepest invasion Al0-Al1 - Full thickness section of polyp, bisected A12-Al3 - Remainder of base of polyp as it inserts into the mucosa A14 - Appendix Al5-A16 - Five lymph node candidates each A17-Al9 - Each contains one lymph node candidate, serially sectioned A20 - One lymph node candidate, bisected A21-A25 - Each contains one lymph node candidate, serially sectioned A26-A27 - Each contains one lymph node candidate, bisected A28 - One lymph node candidate, serially sectioned A29 - Three lymph node candidates A30 - One lymph node candidate, bisected A31 - One lymph node candidate, serially sectioned A32-A34 - One lymph node candidate, serially sectioned MW 7/2s/13
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diff --git a/output/text/0b6f8198-75ff-432a-88d9-9ec68833e8ba.txt b/output/text/0b6f8198-75ff-432a-88d9-9ec68833e8ba.txt
new file mode 100644
index 0000000000000000000000000000000000000000..41dcfd00002a28f8c707c74cb2d0a1d49268ecf4
--- /dev/null
+++ b/output/text/0b6f8198-75ff-432a-88d9-9ec68833e8ba.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+/cs-0-3 Carcinoma, infi1+rahxg duct,N0s 8500/3 Site: busst ,Nos C50.9 h 4f3s|" OC#: TSS # Procurement Date:3/3/2011 Laterality:Right, upper outer quadrant Path Report:BREAST TISSUE CHECKLIST Specimen type: Lumpectomy Specimen size: Not specified Tumor site: Upper outer quadrant Tumor size: 2.2 x 0 x 2.5 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinoma Histologic grade: Poorly differentiated Tumor extent: Not specified Lymph nodes: 0/10 positive for metastasis (Axillary 0/10) Extracapsular invasion of the lymph nodes: Not specified Margins: Uninvolved Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None UUID: 8950E632-451D-4436-9AA2-740CB08237E8 TCGA-E9-A248-01A-PR Redacted rit ++2o/++
\ No newline at end of file
diff --git a/output/text/0ba47fb9-b141-455f-bf42-b508b37cd211.txt b/output/text/0ba47fb9-b141-455f-bf42-b508b37cd211.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a95666c3a33a14b7afe8231c18300b6b3ff0a534
--- /dev/null
+++ b/output/text/0ba47fb9-b141-455f-bf42-b508b37cd211.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+UUID:A4621FE7-E898-40BA-B45E-3DC9EF607F37 TCGA-A2-A3XW-01A-PR Redacted SURGICAL PATHOLOGY REPORT Patient: Specimen #: FMP/SSN: DOB/Age/Sex: (Age: Taken: Location: Received: Physician(s) : Reported: SPECIMEN: A: RIGHT BREAST B: SENTINEL NODE #1 RIGHT AXILLA C: NON SENTINEL LYMPH NODE RIGHT AXILLA D: SENTINEL NODE #2 RIGHT AXILLA : I<D o 3 E: NON-SENTINEL NODE #2 RIGHT AXILLA carcinoma, inF1Hating $u<tj,NO5 ) y`Soof3 FINAL DIAGNOSIS: A. BREAST, RIGHT, MASTECTOMY: 5-Z3-sZ -TUMOR TYPE: INFILTRATING DUCTAL CARCINOMA, NO SPECIAL TYPE. Ro  NOTTINGHAM GRADE: MODERATELY DIFFERENTIATED (G2). NOTTINGHAM SCORE: 7/9. (Tubules-3, Nuclei-2, Mitoses-2 : mitotic count 8 per 10 HpF at. 40x power, slide A5). TUMOR SIZE (GREATEST DIMENSION): 3.0 CM (GrOss measurement). TUMOR NECROSIS: FOCALLY PRESENT IN INFILTRATING COMPONENT. MICROCALCIFICATIONS: PRESENT IN CARCINOMA AND BENIGN BREAST TISSUE. VENOUS / LYMPHATIC INVASION: PRESENT, EXTENSIVE. MARGINS: NEGATIVE DISTANCE OF INFILTRATING TUMOR FROM THE NEAREST MARGIN IS 2.5 MM, FROM THE DEEP MARGIN (Slide A8). SEE COMMENT. INTRADUCTAL COMPONENT: PRESENT. -DUCTAL CARCINOMA IN SITU WITH APOCRINE FEATURES, HIGH NUCLEAR GRADE (G3), CRIBRIFORM AND SOLID TYPES WITHOUT DEFINITE NECROSIS.S LYMPH NODES: SEE PARTS B-E.  NIPPLE INVOLVEMENT: PRESENT WITHIN THE STROMA. SKIN INVOLVEMENT: ABSENT. MULTICENTRICITY: ABSENT. ESTROGEN RECEPTORS: POSITIVE (95-100% Nuclear staining, per PROGESTERONE RECEPTORS: POSITIVE (10% Nuclear staining, per) HER2 by IHC: NEGATIVE (1+; per HER2 BY FISH: NOT PERFORMED. PATHOLOGIC STAGE: pT2 N1a Mx. ADDITIONAL PATHOLOGIC CHANGES: -FIBROCYSTIC CHANGES INCLUDING STROMAL FIBROSIS, MICROCYSTS AND APOCRINE METAPLASIA. -NODULAR SCLEROSING ADENOSIS. -MODERATE-FLORID USUAL DUCTAL HYPERPLASIA. Page 1 Continued on Next Page. FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT Specimen #: Patient: FINAL DIAGNOSIS (continued): -FIBROADENOMATOID CHANGE. -COLUMNAR CELL CHANGE WITHOUT ATYPIA. B. LYMPH NODE, RIGHT AXILLA (#1), SENTINEL BIOPSY: -ONE LYMPH NODE POSITIVE FOR METASTATIC CARCINOMA. -LARGEST METASTATIC FOCUS: 1.5 CM. -MICROSCOPIC FOCUS (O.8 MM) OF EXTRANODAL EXTENSION BY CARCINOMA IDENTIFIED. -SEE COMMENT. C. LYMPH NODE, RIGHT AXILLA, NON-SENTINEL BIOPSY: -ONE OF TWO LYMPH NODES POSITIVE FOR METASTATIC CARCINOMA. -LARGEST METASTATIC FOCUS = 1.1 CM. -NEGATIVE FOR EXTRANODAL EXTENSION BY CARCINOMA. D. LYMPH NODE, RIGHT AXILLA (#2), SENTINEL BIOPSY: -ONE LYMPH NODE, NEGATIVE FOR METASTATIC CARCINOMA BY H AND E AND IMMUNOHISTOCHEMISTRY. -SEE COMMENT. E. LYMPH NODE, RIGHT AXILLA (#2), NON-SENTINEL BIOPSY: -TWO LYMPH NODES, NEGATIVE FOR METASTATIC CARCINOMA BY H AND E. Comment: Part A - The tumor that is closest to the margin is present within a lymphatic space. Parts B and D are examined per the .. sentinel node protocol, with four. step sections and intervening sections examined by immunohistochemistry. for pancytokeratin (x2). Control stains are reviewed.. ** Report Electronically Signed Out ** CLINICAL DIAGNOSIS AND HISTORY: yo diagnosed with right breast cancer PRE-OPERATIVE DIAGNOSIS: right breast cancer Page 2 Continued on Next Page FOR OPFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OP
+
+--- Page 3 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT O! SURGICAL PATHOLOGY REPORT Patient: Specimen #: POST-OPERATIVE DIAGNOSIS: none provided GROSS DESCRIPTION: A: Received fresh, labeled with the patient's name, and designated "Right Breast, long-lateral, short-superior, double-deep. stitches" consists of a 344 gm mastectomy specimen oriented with short superior to inferior, 18.0 cm medial to lateral, and 3.0 cm anterior to posterior. The darkly pigmented superficial skin ellipse measures 9.5 x 3.5 cm and displays a 1.0 cm centrally located, flat nipple free of discharge. The deep margin is inked black and the superficial margin is inked blue. Serial sections reveal a centrally located, well-defined mass measuring 3.0 cm (superior to inferior) x 2.5 x 2.5 cm. The mass is subjacent to (and continuous with) the nipple and comes to within 1.3 'cm. of the deep margin. The cut surface is pink-white, firm and gritty with peripheral congestion. The fibrous tissue surrounding the mass is markedly dense and diffusely nodular, suggestive of an additional focal lesion. The remainder of the specimen is composed moderately of dense fibrous tissue admixed with lobulated, yellow-tan adipose tissue. No lymph nodes are. identified. Representative sections are submitted.. Cassette Summary: A1- nipple with subjacent mass; A2- mass with deep margin; A3-A5- mass; A6- mass with skin; A7-A8- deep margin to tumor, central breast; A9- lower mid, adjacent (inferior) to tumor; A1o- margin of A9; A11- central breast, adjacent (medial) to tumor; A12- margin of A1l; A13- upper outer quadrant, 4.5 cm from tumor; A14- margin of A13; A15- lower outer quadrant, 4.5 cm from tumor; A16- lower inner quadrant with deep adjacent to tumor; Al7- upper inner quadrant adjacent to tumor; Matched sections of A1, A3-A7, A9, Ai1, A13 and A15-A17 are submitted in. ocr for protocol. B: Received fresh, labeled with the patient's name,. designated "Sentinel Node #1 Right Axilla" consists 0r a 1.5 x 1.2 x o.7. and cm possible lymph node. The lymph node is bisected to reveal a firm, tan-white cut surface. The specimen is submitted in cassette B1. A matched section of section of B1 is submitted in ocr for protocol. C: Received fresh, labeled with the patient's name,. designated "Non-Sentinel Lymph Node Right Axilla" consists"of" two possible  and lymph nodes measuring 1.5 x 1.0 x 0.5 cm and 0.5 cm in greatest dimension. The cut surface of the larger possible lymph node is pink-white and firm. The lymph nodes are submitted as follows:. Cassette Summary: C1- one lymph node; c2- one lymph node bisected. A matched section of c1 is submitted in ocr for. protocol. Page 3 Continued on Next Page "FOR OFPICIAL USER ONLY - PERSONAL DATA - PRIVACY ACT OF
+
+--- Page 4 ---
+FOR OEFICIAL USK ONLY - PERSONAL DATA PRIVACY ACT O SURGICAL PATHOLOGY REPORT Specimen #: Patient: GROSS DEsCRIpTION (continued) : : Recai.-i in formalin, labeled with the patient's name. .D:  designated "Sentinel Node #2 Right Axilla" consists of one. rrreguiar shaped fragment of yellow lobular adipose tissue measuring 1.5. cm in greatest dimension. Sectioning reveals one possible lymph node. measuring 0.6 cm in greatest dimension. Specimen submitted in its. entirety. and E: Received fresh, labeled with the patient's name.. designated "Non-Sentinel Node #2" consists of two possible lymph nodes Sectioning measuring 2.0 x 1.0 x 0.7 cm and 0.7 cm in greatest dimension. of both possible lymph nodes reveals a pink-tan, unremarkable cut surface.. The lymph nodes are entirely submitted as follows: Cassette Summary: E1-E2- one lymph node; E3- one lymph node bisected.. protocol. A matahed section of E2 is submitted in ocr for End of Report Page 4 FOR OFPICIAL USE ONLY - PERSONAL DATA - PRIVACY
\ No newline at end of file
diff --git a/output/text/0bb19aad-6073-4a46-81b3-9629f7294d34.txt b/output/text/0bb19aad-6073-4a46-81b3-9629f7294d34.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e25528fd69175c148b9481497c6707a96406e68b
--- /dev/null
+++ b/output/text/0bb19aad-6073-4a46-81b3-9629f7294d34.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1Cs-0-3 Adns csriiom, NOS 8140/3 Site: Cecus18.0 UUID:98310DA6-E41D-4725-A634-D17888A7CFE0 1/2 TCGA-DM-A1D4-01A-PR Redacted (First Tumor) Tumor Site: Cecum Proximal Date of Cancer Sample Procurement: Histology: Adenocarcinoma Description of other histology: Grade: Moderately Differentiated  Yds Mucinous: C No  Yes c Unknown (Focal) ( Yes Signet Ring Feature:  No  Yes r Unknown (Focal) Histologic Heterogeneity:  No C Yes C Unknown Host Response: None Crohn's like reaction  None C Yes C. Unknown Plasma cell rich stroma C No C Yes C Unknown C Expansile C Expansile Growth Pattern:  Invasive C Unknown and invasive Inflammatory Bowel Disease  No C. Yes C Unknown Angiolymphatic Invasion: O No C Yes C Unknown Mutator Phenotype: C No  Yes C Unknown Number of Slides 1 Garland Necrosis present:  Yes C No C Yes C Unknown (Focal) TIL Cells / HPF 2.8 Pathologist Comment: +/- on mutator phenotype
\ No newline at end of file
diff --git a/output/text/0be9a14d-144d-4334-b7d2-98f6c95550ef.txt b/output/text/0be9a14d-144d-4334-b7d2-98f6c95550ef.txt
new file mode 100644
index 0000000000000000000000000000000000000000..151674bfc2cdfb5c785e69073d946c27da8700a6
--- /dev/null
+++ b/output/text/0be9a14d-144d-4334-b7d2-98f6c95550ef.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+D05 n&larnu, speiUulciLEell 8771/3 Date of surgery : Aelsnn., yithudesisk +opinlle Right eye enucleation. cQL mieeL'S770/3 Macroscopy /0 5/1c/14 Enucleation specimen measuring 25 mm in diameter with a segment of optic nerve of 7 mm of length. At the section, presence of a pigmented tumor measuring 20 mm of main line in the posterior chamber. Samples have been made for cryopreservation and cytogenetic studies. The specimen has been then included entirely after fixation in 11 blocks.. Miicroscopy Histological study shows the presence of a malignant melanocytic tumor proliferation developed in the choroid. This tumor is made of epithelioid cells (80%) and also fusiform cells (20%). These cells have marked cytonuclear atypias with nucleolated nuclei. The mitotic index is low (5 mitosis out of 10 high 400 magnification fields). See. peth discrpe Ipithelivid/spinsli cll stio. This tumor is developed posterior to the ciliary processes without extension in the ciliary processes and stays distant to the base of implantation of the optic nerve. This tumor infiltrates the internal third of the sclera without extra sclera extension. The optic foramen, the optic nerve and its cut end are free of tumor.. Conclusion Mixed type (epithelioid and fusiform) choroidal melanoma Size of the tumor: 20 mm main line. Extension to the internal third of the sclera without extrascleral extension.. The optic foramen, the optic nerve and its cut end, the meningeal sheaths are free UUID:8309F1B8-553B-47E7-83D9-5663FCEF17A1 A9E7-01A-PR Redacted
+
+--- Page 2 ---
+TCGA Pathologic Diagnosis Discrepancy Form. V4.00 Instructions: The TCGA Pathologic Diagnosis Discrepancy Form should be completed when the pathologic diagnosis. documented on the initial pathology report for a cuse submitted for TcGA is inconsistent with the diagnosis provided on the. Case Quality Control Form conpleted for the submitted case. Tissue Source Site (TsS): .... TSS Identifier: .  TSs Unique Patient Identifier. Completed By (Interviewer Name on OpenClinica): . Coinpleted Date: .. [Diagnosis Information Data Element Entry Alternatives Working Instructions 80% epithelioid cells  Provide the diagnosis/ histologic subtype(s) documented on Pathologic Diagnosis the initial pathology report for this case. If the histology for Provided on Initia!  this case is mixed, provide all listed subtypes.. Pathology Report 20% spindle ceils Histologic features of 61-90% epithelioid cells.  Provide the histologic features selected on the TCGA Case.  the sample provided Quality Control Form completed for this case.. for TCGA, as reflected 1-30% spindle cells  on the CQCF. Discrepancy between Pathology Report and Case Quality Control Form  Provide the reason for Provide a reason describing why the diagnosis on the initial  the discrepancy The section of the frozen sample used for sending pathology report for this case is not consistent with the.  between the pathology to TCGA corresponds to a section of the tumor  diagnosis selected on the TCGA Case Quality Control Form.  report and the TCGA where the epithelioid part is predominant.. Case Quality Control Form. The  percentages mentioned on the initial.  Pathology Report correspond to an average on the whole embedded sections used for establish the Pathology Report. Name of TSS Reviewing e of the pathologist who  Pathologist or for TCGA.  Biorepository Director I acknowiedge thut the above information provided by my institution is true and correct and has been quality controlled.. TSS Reviewing Pathologist or Biorepository Director. Date 1 acknowigage that the ubove information provided by my institution is true and correct and has been quality controlled. The Attending Puthologist or the Department Chairman has been informed or is aware of the above discrepancy in diagnoses.. Principal Investigator Signature Date
\ No newline at end of file
diff --git a/output/text/0bf5c362-ee85-444a-b130-b7e790269156.txt b/output/text/0bf5c362-ee85-444a-b130-b7e790269156.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3119ae0b9ee5a82a0ef51e47061eb2a5bb9d31b9
--- /dev/null
+++ b/output/text/0bf5c362-ee85-444a-b130-b7e790269156.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TCGA #: 'nternal Sample ID:e Diagnosis: This is a moderately differentiated adenocarcinoma of the sigmoid colon with histopathological grade G2 differentiation, with erosions of the inner tumor surface, with peritumorous, chronic recurrent concomitant inflammation, with tumor infiltration of the parietal layers of the sigmoid colon extending to the outer layers of the tunica muscularis, with chronic lymphadenitis of the tumor-free lymph nodes (0/12) and tumor-free overview sections from the resection margins and from the region of the vascular ligature. According to these section preparations, the tumor spread of the sigmoid colon carcinoma corresponds to a tumor stage of pT2, pN0, MX, R0. JcD-s-3 adtno cuvcnonu, Nos 81yo/3 Sifx: Stgmn'd cHloN C18,7pw 3/3t/n UUID:257FBF57-SD81-44D5-994D-64EFD1CA4ES7 TCGA-AA-A02W-01A-PR Redacted
\ No newline at end of file
diff --git a/output/text/0c364ef0-a6a0-4778-81ac-a0e18ebce96f.txt b/output/text/0c364ef0-a6a0-4778-81ac-a0e18ebce96f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f0e35ec40a89cb43c25f9ffda4453a0db0ecb529
--- /dev/null
+++ b/output/text/0c364ef0-a6a0-4778-81ac-a0e18ebce96f.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis: Resected rectosigmoid sample including a moderately differentiated adenocarcinoma of the colorectal type, located 3.5 cm aborally of the aboral resection margin, measuring max 2.3 cm in diameter, with infiltration of the tunica muscularis propria and two regional lymph. node metastases. Stage of tumor: pT2, pN1 (2/16) MX; G2, V0, R0
\ No newline at end of file
diff --git a/output/text/0c416014-f059-4853-829e-74caece363fe.txt b/output/text/0c416014-f059-4853-829e-74caece363fe.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c2225df729ae4b887513ecfaf339a5702065ccb8
--- /dev/null
+++ b/output/text/0c416014-f059-4853-829e-74caece363fe.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+ICDOr3 S.eb;CKeluy NOs Co4.9 UUID:50F41977-E4BF-406C-A5D4-DCBE9D5992F7 Redacted 1J b/I3|i4 Papillary Renal Cell Carcinoma, Type I, well differentiated. Maximum dimensions: Piece 1 4.2 cm,. piece 2 0.1 cm. The kidney parenchyma presents with a high-grade interstitial fibrosys and ectatic vasculature at the borders. Stage: pT1b, R0 Grade: GI ICD-0-Code: 8260/3 Laterarin bJ 5/4/14
\ No newline at end of file
diff --git a/output/text/0ca0e949-610e-45b1-ba23-8366e867f9ed.txt b/output/text/0ca0e949-610e-45b1-ba23-8366e867f9ed.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2b2a0fee01b478bf32ced9390ca0dfade32c3c22
--- /dev/null
+++ b/output/text/0ca0e949-610e-45b1-ba23-8366e867f9ed.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Patient Name: Accession #: Med. Rec. #: Date of Procedure DOB Date of Receipl: Gender. Ref. Physician: Date of Report Account #: Patient Address Billing Type Additional Copy to Ret. Source Clinical Diagnosis & History: Left renal mass >6 cm Spocimens Submitted:. 1: SP: Kidney, lell, total nephectomy 2: SP: Lymph nodes, preaodic and para-aorlic, disseclion  3: $P: Adrenal gland and suprahilar lymph node, left, excision. 4: SP: Lynph nodes, teft hilar, disseclion DIAGNOSIS: SP: Kidney, loft, total nephrectomy Tumor Type  Renal cell carcinoma - Unclassified type Angiomyolipomo, 1 cm in greatest dimension. SEE COmMENT. Fuhrman Nuclear Grade: High nuclear grade Tumor Size: Greatest diameler is 6.5 cm.. Local Invasion (tor renal cortical lypes): Not Identified Renal Vein Invasion. Not identified Surgical Margins: Free of tumor The renal artery exhibits moderale atherosclerotic changes with stenosis at the margin Non-Neoplastic Kidney:.  Mild arterionephrosclerosis and benign simple cortical cysis (PAS stain supports). Adrenal Gland: See pad 3 Lymph Nodes: See parts 2 & 4  Staging for renal cell carcinoma/oncocyloma: pT1 Tumor <= 7.0 cm in greatest dimension linited to the kidney. Page I 01 3
+
+--- Page 2 ---
+COmmenT: The tumor exhibils predominat papillary features with focal solid and clear cell morphology. Tumor cells have large eosinophilic to clear cyioplasm and pleomorphic nuclei with open chromatin and occasional nuleoli. By immunostains, the tumor was reactive with CD10 and CA-IX but negative for AE1:AE3, EMA, CK7 and racemase. Staining lor TFE3 and TFEB (for.  translocation renal cell carcinumas) was also nogative. This overlapping morphology and immunoprofile does not allow for placing this tumor in any of the well recognized categories and is thus deignaled UNCLASSIFIED TYPE. The morphology along with the presence of an angionvolinoma however nors that we encountered in patients with tuberous sclerosis. This case was reviewed al 2. SP: Lymph nodes, orc and para-aoruc, dlsseclion: Lymph Nodes: Not involved Number of nodes examined:17 Segment of benign ureter 3, SP: Adrenal gland and suprahilar lymph node, left, excision: Benign adrenal gland and periadrenal adipose tissue No lynph nodes identified 4. SP: Lymph nodos, left hilar, dissection. Lymph Nodes: Not involved Number of nodes examined:4 Some of the inmunotustochemistry and ISh tesls wore developed and their perigrmance charactristics were determined by the Department o! Pathology. They have not boon cleared or approved by the US Foos and Druy Administation The FDA has determined that such cioarance or approval is not ncccssary. These tests are hould not be regarded as investigational or for research. This tatoratory is cenihed under the Chnical Laboralory improveinent. S qualned to perforin high complexity ctinical labaratory testing. TARTEST THAI THE ABOVE DIAGNOSIS IS BASEI UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL). AND THAT IHAVE REVIEWED AND APPROVEO THIS REPORT Special Studies: Result Special Stain Comment CA-1X. CD10 AE1:AE3 EMA CK7 CD117 RACEMASE IMM H&E IMM RECUT PAS NEG CONT HMR-45 A103-1 HMB-45 A103-1 IMM RECUT NEG CONT IMM RECUT NEG CONT Gross Description: 1) The specimen is rece dney" and consists of a kidney with atlached ureter, renal vessels and perinephric fal weighing 812 g in total measuring 22 x 13 x 8 cm ovorall. The kidney measures 12.2 x 9 x 4 cm. The altached ureler.  measures 7 cm in length and 0.6 cm in diameter.  The attached renal vein measures 2 cm in lenglh and 1 cm in diamoter. The renal vessels and ureler margins are grossly unremarkable. An adienal gland is not identified. The kidney is inked black and Page 2 of 3
+
+--- Page 3 ---
+bivalved to reveal a hemorrhagic golden yellow and red tumor at mid portion measuring 6.5 x 6 x 4.5 cm. Sections through the. remainder of the kidney reveal a pink brown parenchyma, with a welf-defined cortico-medullary junclion. There is a second nodule in the lower pole measuring1 x 0.6 x 0.6 cm showing a tan gray cut surlace. The cortex measures 1 cm and the calycos appear. normal. No lymph nodes are identified in the perinephric fat. The spocimen is photographed. Represenlative sections are submilted for TPS and for permanent sections. Summary of sections: UM -- ureteral margin, VM- vascular margin, T- tumor, TSF -- lunor with sinus fat.  RP -- renal pelvis representative sections, K -- representative sections kidney, T2- second cortical nodule. 2).The specinen is rece formalin, labeled *preaortic and para-aortic lymph nodes" and consists of muitiple pink tan firm Iymph nodes ranging from 0.5 to 3.8 cm in greates! dimension.  All identified lymph nodes are submitted. Summary of sections: LN -- lymph nodes, BLN -- bisecled lymph nodes, QLN -- quadrisecled lymph node. 3) The specimen is'received fresh labeled as *Lelt adrenal gland suprahilar lymph node" and consists of a fragmented piece of. adipose tissue measuring 9 x 7.5 x 1.5 cm, containing an adrenat gland measuring 6 x 3.5 x 1 cm. The cut section of adrenal. reveals a golden yellow cortex and dark brown medulla, which is grossly unremarkable. The specinen is representatively submitted as follows. Summary of Sections: A- adrenal, F-fat 4). The specimen is received in formalin, labeled "hilar lymph node, left' and consists of four pink tan frm lymph nodes ranging. from 0.5 to 1 cm in grealest dimension. Allidentified lymph nodes are submitted. Summary of sections: LN -- lymph nodes. BLN -- bisected lymph node Summary of Sections: Part 1:  SP: Kidney, left, total nephrectomy Block Sect. Sito PC$ 2 k 2 ? rp N  7 t 3 12 3 5 tsf 5 1 um 1 vIm 1 Part 2:  SP: Lymph nodes, preaortic and para-aortic, dissection Block Sect. Site PCs 3 BLN 7 LN 13 4 QLN 4 Part 3:  SP: Adrenal gland and suprahilar lymph node, left, excision Block Sect. Site PCs 2 ad 2 3 f 3 Part 4:  SP: Lymph nodes, left hilar, dissection Btock Sect. Site pCs 1 8LN N 2 LN 3 Page 3 0f 3 END OF REPORT
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diff --git a/output/text/0cb052a9-3e32-4559-9492-8b6837a3ce7d.txt b/output/text/0cb052a9-3e32-4559-9492-8b6837a3ce7d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..aa621934b27aacc409a05d6066a865ebac381447
--- /dev/null
+++ b/output/text/0cb052a9-3e32-4559-9492-8b6837a3ce7d.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+IC-0-3 Cucnma, nf1+netNg 1obulau 8520/3 TSS Pt ID: CQcF Sit: but,nrs c5o.9 10/19110 SPECIMENS: UUID:71C82089-E070-4C7B-B15B-0492DECCB3BF A. SLN #1 TCGA-E2-A10F-01A-PR Redacted B. SLN #2 C. LEFT BREAST WLE D. ADDITIONAL LATERAL MARGIN E. MEDIAL LEFT BREAST TISSUE F. LATERAL LEFT BREAST TISSUE G. RIGHT BREAST TISSUE SPECIMEN(S): A. SLN #1 B. SLN #2 C. LEFT BREAST WLE D. ADDITIONAL LATERAL MARGIN E. MEDIAL LEFT BREAST TISSUE F. LATERAL LEFT BREAST TISSUE G. RIGHT BREAST TISSUE GROSS DESCRIPTION: A. SLN #1 Received fresh is a tan pink lymph node 2.0 x 0.8 x 0.7cm. The specimen is sectioned and a touch prep is taken. Toto A1. B. SLN #2 Received fresh is a tan pink lymph node 0.5 x 0.5 x 0.5cm. The specimen is sectioned and a touch prep is taken. Toto B1. C. LEFT BREAST WLE Received fresh is an oriented (short-superior, long-lateral, looped-anterior) 266g, 7.0cm anterior to posterior, 10.5cm superior to inferior and 12.0cm medial to lateral, lumpectomy with needie localization wire. The specimen is inked as follows: Anterior-Blue, Posterior-Black, Superior-Red, Inferior-Orange, Medial-Green, Lateral-Yellow. The specimen is serially sectioned from medial to lateral into 7 slices, slice 1 being most medial, slice 7 being most lateral to reveal a gray white stellate firm mass 2.6 x 1.8 x 1.4cm, 1 cm from the closest deep margin in slices 5 and 6. A 0.5 cm nodule is identified, 0.4cm from the deep margin and 1.5cm from the mass in slice 6. A 0.6 cm nodule is also identified, 0.5cm from the deep/lateral margin in slice 7. A surgical clip is identified in slice 6. A portion of the specimen is submmitted for tissue procurement. Representative sections are submitted as follows: C1-C3: medial margin perpendicular from superior to inferior slice 1 C4: superior/deep margin slice 2. C5: slice 2 C6: deep margin slice 2 C7: slice 2 C8: inferior margin slice 2 C9-C10: deep margin slice 3 C11-C13: slice 3 from superior to inferior with C13 inferior margin C14: deep/inferior margin slice 3. C15-C16: deep margin slice 4 C17-C18: next to mass slice 4 C19-C20: deep margin slice 4 C21: inferior margin slice 4 C22: superior margin slice 5 C23: deep margin slice 5 C24-C26: mass slice 5 C27: anterior margin slice 5 C28: inferior margin slice 5 C29: superior margin slice 6 C30-C31: deep margin slice 6 C32: above mass slice 6 C33: mass slice 6- clip C34: satetlite nodule slice 6 C35: area in between mass and nodule slice 6 C36: inferior margin slice 6
+
+--- Page 2 ---
+C37: perpendicular sections next to mass, slice 7 C38-C39: nodularity slice 7 As per attached diagram D. ADDTlONAL LATERAL MARGIN-Stitch at final margin Received fresh is an oriented 53g fragment of fibrofatty tissue 10.0 x 6.0 x 3.0cm. The new true margin is inked Blue and the specimen is serially sectioned to reveal grossly unremarkable breast parenchyma Renresentative sections are submitted in D1-D10. E. MEDIAL LEFT BREAST TISSUE Received in formalin is a 321 g, 25 x 9 x 4 cm yellow-tan fibrofatty breast tissue with 17 x 5 cm skin. The breast parenchyma consists primarily of fatty breast tissue with few fibrous areas identified. No masses or lesions are seen. Representatively submitted in cassettes E1-E5. F. LATERAL LEFT BREAST TISSUE Received in formalin is a 238 g, 12 x 10 x 2.5 cm yellow-tan fibrofatty breast tissue with 12 x 8 cm skin. On sectioning no masses or lesions are observed. Representative sections are submitted in cassettes F1-F3. G. RIGHT BREAST TISSUE Received in formalin and are multiple pieces of yellow-tan fibrofatty breast tissue with the largest portion having attached tan skin. The specimen weighs 961 g; the intact tissue measures 40 x 11 x 4.5 cm. On. the surface are two irregularly shaped pieces of tan skin measuring 16 cm in length and 6.5 cm in width and 12 cm in length by 4 cm in width. The skin surface is unremarkable. The detached fibroadipose tissue in aggregate measures 12.5 x 8.5 x 3.5 cm. On sectioning the specimen is comprised primarily of adipose tissue. No masses or lesions are observed. Representative sections are submitted in cassettes G1-G10. DIAGNOSIS: A. SENTINEL LYMPH NODE #1, LEFT AXILLA, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR CARCINOMA (0/1) B. SENTINEL LYMPH NODE #2, LEFT AXILLA, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR CARCINOMA (O/1). C. BREAST, LEFL/NEEDLE LOCALIZATION WIDE LOCAL EXCISION: - INVASIVE LOBULAR CARCINOMA, MODERATELY DIFFERENTIATED (SBR GRADE 2). - TUMOR MEASURES 2.6 CM IN GREATEST DIMENSION. - MARGINS, NEGATIVE FOR CARCINOMA. - LOBULAR CARCINOMA IN SITU - FOCAL ATYPICAL DUCTAL HYPERPLASIA. - COLUMNAR CELL CHANGE WITH CYTOLOGIC ATYPIA (FLAT EPITHELIAL ATYPIA). D. BREAST, LEFT, ADDITIONAL LATERAL MARGIN, EXCISION: - BREAST TISSUE, NEGATIVE FOR CARCINOMA. E. BrEaSt, LEft, meDiAl TISSUE, EXcISIOn: - COLUMNAR CELL CHANGE WITH FOCAL CYTOLOGIC ATYPIA (FLAT EPITHELIAL ATYPIA), USUAL DUCTAL HYPERPLASIA, AND FIBROADENOMATOID CHANGE, NEGATIVE FOR CARCINOMA - SKIN, NEGATIVE FOR CARCINOMA. F. breaSt, Left, Lateral Tissue, excision: - BREAST TISSUE, NEGATIVE FOR CARCINOMA. G. BREAST, RIGHT, EXCISION: - COLUMNAR CELL CHANGE WITH FOCAL ARCHITECTURAL AND CYTOLOGIC ATYPIA (FLAT EPITHELIAL ATYPIA) (SEE NOTE). - BENIGN SKIN. SYNOPTIC REPORT - BREAST
+
+--- Page 3 ---
+Specimen Type: Excision Needle Localization: Yes - For mass Laterality: : Left: Invasive Tumor: Present Multifocality: No WHO CLASSIFICATION Invasive lobular carcinoma. 8520/3 Tumor size:  2.6cm.. Tumor Site.* 3:00.... Margins: Negative Distance from closest margin: 1cm deep Tubular Score: 3 Nuclear Grade: 2 Mitotic Score: 2 Modified Scarff Bloom Richardson Grade: Necrosis: Absent Vascular/Lymphatic Invasion: None identified. Lobular neoplasia: LCIS Lymph nodes: Sentinel lymph node only Lymph node status: Negative 0/2 Non-neoplastic areas: columnar cell change, usual ductal hyperplasia, fibroadenomatoid change. DCIS not present ER/PR/HER2 Results ER: Positive PR: Positive HER2: Negative by FISH Pathological staging (pTN): pT 2 N 0 CLINICAL HISTORY: yr old lady underwent screening mammo Left breast density. 3 o'clock position 2.6 x 2.7cm. Core bx showed invasive ductal carcinoma. ER/PR +, Her2 Negative. Now for WLE needle loc lumpectomy, SLNB. PRE-OPERATIVE DIAGNOSIS: Left Breast IDC INTRAOPERATIVE CONSULTATION: TPA/TPB: Negative for tumor cells. Diagnosis called to Dr. at. by Dr. C. Left breast - mass > 1 cm from all margins, nodularity present with minute nodule 0.5cm from. posterior/lateral marain. Per Dr., no gross exam needed on additional latera! margin (Part D). Diagnosis called to Dr. at . by Dr.. ADDENDUM: NOTE: This addendum is issued to give the results of IHC as well as to correct an error in the diagnosis for part G. In part G, it says "(SEE NOTE)"; however, there is no note and therefore, the "(SEE NOTE)' is an error. The diagnosis remains unchanged.. SUMMARY OF IMMUNOHISTOCHEMISTRY/SPECIAL STAINS Material: Block C25 Population: Tumor Cells Stain/Marker:Result:  Comment: ECADHERINNegativeSupports lobular differentiation
+
+--- Page 4 ---
+The interpretation of the above immunohistochemistry stain or stains is guided by published results in. the medical literature, provided package information from the manufacturer and by internal review of  staining performance and assay validation within the Immunohistochemistry Laboratory of the The use. of one or more reagents in the above tests is regulated as an analyte specific reagent (ASR). These tests were developed and their performance characteristic determined by the Department of Pathology. Laboratory at. They have not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary.. Special stains and/or immunohistochemical stains were performed with appropriately stained positive and negative controls. Gross Dictation.., Pathologist Microscopic/Diagnostic Dictation:., Pathologist,. Final Review.., Pathologist, Final Review: Patholoqist. Final:, Pathologist, C Addendum: Pathologist Addendum Final:., Pathologist, HIPAA
\ No newline at end of file
diff --git a/output/text/0cb4d170-dbe0-4ae3-8bb6-fa238e75742a.txt b/output/text/0cb4d170-dbe0-4ae3-8bb6-fa238e75742a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c87d0c610665d9cb66844c104c843ed1125949a9
--- /dev/null
+++ b/output/text/0cb4d170-dbe0-4ae3-8bb6-fa238e75742a.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+TCGA-B9-4114 SURGICAL PATHOLOGY Surgical Pathology Report Accession #: Diagnosis: Kidney, left, radical nephrectomy Histologic tumor type/subtype: Papillary renal cell carcinoma with necrosis Histologic grade (if applicable): Fuhrman grade 3 Tumor size (greatest dimension): Multi-focal, largest focus is 22 cm in greatest dimension Extent of tumor invasion: Capsular invasion/perirenal adipose tissue: Negative for tumor; the capsule is focally thinned, but intact Gerota s fascia: Negative for tumor Renal vein: Negative for tumor Ureter: Negative for tumor Venous (large vessel) Negative for tumor Lymphatic (small vessel): Present Histologic assessment of surgical margins: Perirenal adipose tissue: Negative for tumor; closest perirenal adipose tissue margin at area of focally thinned capsule is 1 mm.A5). Gerota's fascia: Negative for tumor Renal vein: Negative for tumor Renal artery: Negative for tumor Ureter: Negative for tumor
+
+--- Page 2 ---
+Adrenal gland: Not present Lymph nodes: Not identified grossly Other significant findings: Focal glomerulosclerosis AJCc Staging: pT2 pNx pMx This staging information is based on information available at the time of this report, and is subject to change pending clinical review and additional information. Clinical History: with a clinical history of a large left renal mass, now undergoing left radical nephrectomy the patient has known papillary renal cell carcinoma. Gross Description: Received is one appropriately labeled container, additionally labeled "left kidney." Specimen fixation:formalin Type of specimen: radical nephrectomy Side of specimen: left Size and weight ofspecimen:2,370 grams;22x17 x12 cm Orientation: Inking: exterior surface=black Presence/absence of adrenal gland: absent Tumor description/site: Tumor effaces and expands almost the entire kidney parenchyma. Tumor size:22 x 15 x12 cm Presence/absence of multicentricity: multicentric with at least very large abutting masses and several peripheral satellite masses; the largest masses are at least 10 cm in
+
+--- Page 3 ---
+greatest dimension each Confinement/non-confinement to the kidney: tumor appears to abut, but does not extend through the renal capsule NOTE: Upon receipt in the gross room, an approximately 4.5 cm defect on the exterior surface of the specimen is noted, through which tumor extrudes. This site is inked yellow. Extent of invasion: Perirenal adipose tissue: tumor grossly does not involve Gerota' s fascia: tumor grossly does not involve Renal vein: tumor grossly does not involve Ureter: tumor grossly does not involve Other organs: not applicable Surgical margins: Perirenal adipose tissue: grossly negative Renal vein: grossly negative Renal artery: grossly negative Ureter: grossly negative Description of kidney away from tumor: Compressed, but grossly unremarkable. Lymph nodes (hilar): not identified Other significant findings: none Tissue submitted for special investigations: normal and tumor sample tissue provided to Tissue Procurement. Digital photograph taken: not taken Block Summary: Inking: exterior surface=black, area of defects noted (as described above) upon receipt in the gross room-yellow) Al -hilar vascular and ureteral margins, en face A2- additional sampling of hilum A3-tumor A4- tumor, possibly involving collecting system A5 -tumor, ?extracapsular extension A6 -tumor,?extracapsular extension adjacent to A5) A7 -tumor, ?extracapsular extension (adjacent to A6) A8 - tumor, site of defect noted on exterior surface at time of receipt A9- tumor interface with normal kidney
+
+--- Page 4 ---
+Al0 -tumor, two non-adjacent sections A11- tumor with perinephric fat A12 tumor with perinephric fat A13 additional tumor,abutting capsule A14 additional tumor, abutting capsule, adjacent to A13 A15 tumor, center of one dominant mass A16 - A17A18 - grossly normal appearing renal parenchyma A19,A20 -perirenal adipose tissue
\ No newline at end of file
diff --git a/output/text/0cb79421-f1b5-40a4-8ab1-6b06d03b8420.txt b/output/text/0cb79421-f1b5-40a4-8ab1-6b06d03b8420.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e4672d589a4c80745b72548405518882f47f26c8
--- /dev/null
+++ b/output/text/0cb79421-f1b5-40a4-8ab1-6b06d03b8420.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+LARGE INTESTINE TISSUE CHECKLIST Specimen type: Hemicolectomy Specimen size: Not specified Tumor site: Colon Tumor size: 6.5 x 4.5 x 4 cm Tumor features: None specified Histologic type: Adenocarcinoma Histologic grade: Well differentiated Tumor extent: Muscularis propria Lymph nodes: Not specified Margins: Not specified Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified. Comments: None
\ No newline at end of file
diff --git a/output/text/0cc58d8c-1849-48b0-a41a-b6eb82a3b86e.txt b/output/text/0cc58d8c-1849-48b0-a41a-b6eb82a3b86e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..62e7b27b38e93779b0c6915199330e33c9acff4d
--- /dev/null
+++ b/output/text/0cc58d8c-1849-48b0-a41a-b6eb82a3b86e.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UUID:60FF0C39-8A92-44AF-BF52-841368174119 TCGA-LN-A4A8-01A-PR Redacted Tel: Fax: Clinical Case Report 1cs-0-3 (For Collection of Cancerous Tissue) CouCin0mo, Squsno all, Nos 8070/3 Sifxr esophsqu, mddlthid C15,4 10[3113 Informed Consent I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution.' Name of Physician or Study Coordinator signature Date Clinical Information GENERAL INFORMATION Date of Birth (mm/dd/yyyy) Helght  Marital Status Race mFs Temperature Single yMarried Gender izNmE$= Weight  Divorced  Widow Male Blood Pressure   Female 6 Q ccA Heart Rate 12/0 HISTORY OF PRESENT ILLNESS Chief Complaints: Flo uhle e Suallwing ; Joc.al chaneye Symptoms: Tined of Clinical Findings: Performance Scale (Karnofsky Score):  100 Asymptomatic   80-90 Symptomatic but Fully Ambulatory '60-70 Symptomatic, in bed less than 50% of day  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden  20-30 Bed Ridden CURRENT MEDICATIONS Drug Dose Route Freguency Date (mm/dd/yyyy) To / To / 1 To / To / / To
+
+--- Page 2 ---
+PAST MEDICAL HISTORY Dlagnosis/Disease/Disorder/Injury Diagnosis Date Treatment Status OB/GYN HISTORY  Menopausal Status Date of First Menses. # of Pregnancies  Pre-menopausal  Peri-Menopausal Date of Last Menses # of Live Births  Post-menopausal Birth Control:  Condom  Oral Contraceptive  iUd  Hormone Replacement Therapy:  Other: SOCIAL HISTORY Environmental Hazards: Occupation: Smoking History Current Status TyPE Packs/day Duratlon When Quit  yes  SONO (yrs) (yt) Alcohol Consumption TYPE Drinks/day Duratlon When Qult Current Status YES ONO 9.clcsI dag (yrs)3mmths ag (yr Drug Use TYPE Freguency Duration When Quit Current Status D yeS ENO (yrs)  (yr) FAMILY MEDICAL HISTORY  Relative Dlagnosis Age of Diagnosis LAB DATA Resuit Date Test  Result Test Date HIV Negative  Positive: CEA  Negative  Positive: Hep B  Negative  Positive: CA 15-3  Negative  Positive: Hep C  Negative  Positive: CA 19-9  Negative  Positive: AFP   Negative  Positive: PSA  Negative  Positive: Other: Other:  Negative  Positive:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+DIAGNOSTIC STUDIES Study  Results Date Ultrasound X-Ray CT Atucneuy was foure in tho cesophoqus Endoscopy  MRI Biopsy CLINICAL DIAGNOSIS Preoperative Clinical Diagnosis EhBeqa  Location of Suspected Involved Lymph Nodes Location of Suspected Distant Metastasis Clinical Staging Date of Dlagnosis T2 NO M O Stage: IA Treatment Informationd : SURGICAL TREATMENT. Procedure Date of Procedure resectim sy che oeaepsaas Primary Tumor Organ Detailed Location  Size Qesopsi Fs lumer Middle. Shird 2x 2 x/ cm Extension of Tumor Lymph Nodes Description Location of Lymph Nodes. # of Lymph Nodes Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Organ Detailed Location Size Surgical Staging T2. No. Stage: NEOADJUVENT THERAPY (Chemo, Radiation, Immuno, Hormonal, or Molecular) Drug/Treatment Dose Route Frequency Date (mm/dd/yyy) To To 1 To To To 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by: -- Date. 'ime . Date Time Preserved by: - SPECIMEN TYPE (# of samples provided) Paraffin Block Blood/Serum/Plasma Slide Frozen Normal Diseased NormaJ Diseased  Normal Diseased Normal Diseased 2 2 2 2 2 Time to LN2 Time to Formalin Time to LN2 min min min /D PATHOLOGICAL DESCRIPTION Primary Tumor Slze Extenslon of Tumor. Distance to NAT Organ Zimur 2Xx2 x4 cm midelle thire 6 Ceso phd ue. cm Lymph Nodes Locatlon # Examined # Metastasized Distant Metastasis Detailed Location. Size Organ Pathological Staging. pT 2. N c m o Stage: T Notes: 4
+
+--- Page 5 ---
+cOnsolIdated DIagnostIc patholOgy form* Microscopic Appearance: Histological pattern: 1. CELL DISTRIBUTION Diffuse + STRUCTURAL PATTERN X) Streaming Mosaic Y Storiform Necrosis Fibrosis  Lymphocytic Infiltration  Palisading Vascular Invasion Cystic Degeneration Clusterized Bleeding Alveolar Formation Myxoid Change Indian File 0Psammoma/Calcification 2. Cellular features: Squamous Adenomatous +  Sarcomatous + Lymphomatous  Squamoid Cell Glandular cell Round Cell + : Large Cell  Spindle Cell  Cell Stratification Fibroblast Keratin Small Cell Secretion Ostcoblast  RS Cell/RS Like Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell Pearl  Gland formation Myoblast Otherwise Specified:  Plasma Cell D75% Dz75Z 2. Cellular Differentiation: Well Moderately Poor K  Nuclear Atypia: Nuclear Appearance Aniso Nucleosis Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity Nuclear Grade Histological Diagnosis: Sgnomrs lel lakeinsre 6-Z Comments: Director, Research Pathology Date *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND "ATHOLOGIST STAFF FOR RESEARCH USE ONLY) DISQUALIFI
\ No newline at end of file
diff --git a/output/text/0ce00a0f-4900-42e2-98ca-30c75ce5618f.txt b/output/text/0ce00a0f-4900-42e2-98ca-30c75ce5618f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3e49dbede675934216201ce203278ae82f49d59c
--- /dev/null
+++ b/output/text/0ce00a0f-4900-42e2-98ca-30c75ce5618f.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Formatted Path Report LARGE INTESTINE TISSUE CHECKLIST Specimen type:  Excision of tumor Specimen size: Not specified Tumor site: Sigmoid colon Tumor size: 7 x 6 x 1.7 cm Tumor features: Exophytic (polypoid) Histologic type: Adenocarcinoma Histologic grade: Moderately differentiated Tumor extent: Muscularis propria Lymph nodes: 0/5 positive for metastasis (Regional 0/5) Margins: Uninvolved Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None
+
+--- Page 2 ---
+Date of Procurement
\ No newline at end of file
diff --git a/output/text/0ce2e6f8-7827-4f37-9635-fa446627cbc8.txt b/output/text/0ce2e6f8-7827-4f37-9635-fa446627cbc8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d8f36fb711bc39443436e6efd9a1a91d9512c403
--- /dev/null
+++ b/output/text/0ce2e6f8-7827-4f37-9635-fa446627cbc8.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+Page 1 of 6 UUID:AEE369FF-8CC6-4E32-AD71-A55B11595314 tCgA-XF-A8hB-01A-pR Redacted DIAGNOSIS: ANTERIOR EXENTERATION WITH ILEO CONDUIT AND GASTROSTOMY TUBE PLACEMENT: RIGHT MEDIAL URETER (A): FROZEN SECTION DIAGNOSIS: Icd -0 3 NEGATIVE FINAL DIAGNOSIS: Cerensne, peapislar BENIGN URETER  NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED Bunstinol' 8/30|3 RIGHT LATERAL URETER (B): Sib YBasder NOS FROZEN SECTION DIAGNOSIS: C67.4 NEGATIVE FINAL DIAGNOSIS: BENIGN URETER YS1/zx/i4 NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED RIGHT DISTAL URETER (C) : BENIGN URETER  NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED LEFT DISTAL URETER (D) : FROZEN SECTION DIAGNOSIS: NEGATIVE FINAL DIAGNOSIS: BENIGN URETER  NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED UTERUS, CERVIX, BILATERAL OVARIES AND FALLOPIAN TUBE AND BLADDER (E) : BLADDER: INVASIVE PAPILLARY UROTHELIAL (TRANSITIONAL CELL) CARCINOMA (5.5 X 3.5 X 1.5 CM), HIGH GRADE 3-4/4, INFILTRATING INTO THE DEEP MUSCULARIS PROPRIA, BUT NOT THROUGH IT MULTIFOCAL HIGH GRADE DYSPLASIA WITH CARCINOMA IN SITU (FLAT LESION) ON ANTERIOR, POSTERIOR AND LEFT LATERAL URINARY BLADDER WALL ALL SURGICAL MARGINS, FREE OF TUMOR PERIVESICAL LYMPH NODES:  NO TUMOR IDENTIFIED IN FIVE LYMPH NODES EXAMINED (O/5) UTERUS :  CERVIX, CHRONIC CERVICITIS WITH SQUAMOUS METAPLASIA ENDOMETRIUM, PROLIFERATIVE ENDOMETRIUM MYOMETRIUM, NO SIGNIFICANT LESION SEROSAL SURFACE, NO SIGNIFICANT LESION BILATERAL FALLOPIAN TUBES, NO SIGNIFICANT LESION BILATERAL OVARIES, NORMAL PHYSIOLOGIC CHANGES LEFT PARA AORTIC LYMPH NODES (F) :  NO TUMOR IDENTIFIED IN FOUR LYMPH NODES EXAMINED (O/4) RIGHT PARACAVAL LYMPH NODES (G) :  NO TUMOR IDENTIFIED IN THREE LYMPH NODES EXAMINED (0/3) RIGHT COMMON ILIAC LYMPH NODES (H) :  NO TUMOR IDENTIFIED IN THREE LYMPH NODES EXAMINED (O/3) LEFT COMMON ILIAC LYMPH NODES (I) :
+
+--- Page 2 ---
+Page 2 of 6. TUMOR IDENTIFIED IN TWO LYMPH NODES EXAMINED (0/2) RIGHT LYMPH NODE OF CLOQUET (J):  NO TUMOR IDENTIFIED IN TWO LYMPH NODES EXAMINED (O/2) RIGHT EXTERNAL ILIAC LYMPH NODES (K) : FIBROFATTY TISSUE NO LYMPHOID TISSUE OR TUMOR IDENTIFIED (O/O) RIGHT OBTURATOR / HYPOGASTRIC LYMPH NODES (L) :  NO TUMOR IDENTIFIED IN FOUR LYMPH NODES EXAMINED (O/4) LEFT EXTERNAL ILIAC LYMPH NODES (M) :  NO TUMOR IDENTIFIED IN SEVEN LYMPH NODES EXAMINED (O/7) LEFT LYMPH NODE OF CLOQUET (N):  NO TUMOR IDENTIFIED IN THREE LYMPH NODES EXAMINED (0/3) LEFT OBTURATOR / HYPOGASTRIC LYMPH NODES (O) :  NO TUMOR IDENTIFIED IN 12 LYMPH NODES EXAMINED (0/12) RIGHT PRESCIATIC LYMPH NODES (P) : FIBROFATTY CONNECTIVE TISSUE  NO LYMPHOID TISSUE OR TUMOR IDENTIFIED (O/0) PRESACRAL LYMPH NODES (Q) : FIBROFATTY CONNECTIVE TISSUE NO LYMPHOID TISSUE OR TUMOR IDENTIFIED LEFT PRESCIATIC LYMPH NODES (R) : FIBROFATTY CONNECTIVE TISSUE NO LYMPHOID TISSUE IDENTIFIED LEFT PROXIMAL URETER (S) :) BENIGN URETER NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED RIGHT MEDIAL PROXIMAL MARGIN OF URETER (T) :) BENIGN URETERS  NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED RIGHT INTERNAL PROXIMAL URETERAL MARGIN (U) :) NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED ISOLATED LYMPH NODE (V): ENTIRE LYMPH NODE REPLACED BY FATTY TISSUE NO LYMPHOID TISSUE OR TUMOR IDENTIFIED (O/O) LYMPH NODE SUMMARY: NO TUMOR IDENTIFIED IN 45 LYMPH NODES EXAMINED (0/45) PATHOLOGIC TNM STAGE: pT2bNOMx Electronically signed by Verified:
+
+--- Page 3 ---
+Page 3 of 6 COMMENT: notified of the results on SPECIMEN SOURCE: A: "Right M F/S" B "Right L F/S" C: "RT. distal ureter" D: "LT. distal ureter F/S" E: F G: "Right para caval L.N." H: "Rt. common iliac L.N." I: "Lt. common iliac L.N." J: "Rt. L.N. of cloquet" K: "Rt external iliac L.N." L: "Rt. obturator / hypogastric L.N." M: N: "Lt. L.N. of cloquet" Q "Pre sacral L.N." R: "Lt. pre sciatic L.N." S: "Lt proximal ureter" T: "Right medial proximal margin of ureter". U: "Right internal proximal ureteral margin". V: "Isolated lymph node" CLINICAL INFORMATION: Pre-Op Dx:  Bladder cancer Post-op Dx:  Same GROSS EXAMINATION: A: The specimen is received fresh from the O.R. and labelled "Right M F/s". It consists of a portion of ureter measuring 0.4 cm in length and 0.4 cm in diameter. The specimen is entirely submitted for frozen section in cassette in cassette AFs. The specimen is received fresh from the O.R. and labelled "Right L F/s". It consists of a portion of ureter measuring 0.4 cm in length and o.5 cm in diameter. The specimen is entirely submitted for frozen section in cassette Brs. C: The specimen specimen is received fresh from the O.R. and labelled "RT. distal ureter". It consists of a portion of ureter measuring 0.4 cm in length and 0.6 cm in diameter. The specimen is entirely submitted in one cassette for permanent section. The specimen is received fresh from the O.R. and labelled "LT. distal ureter. D F/sn. It consists of a portion of ureter measuring 0.4 cm in length and 0.6 cm in diameter. The specimen is entirely submitted for frozen section in cassette DFs. E: The specimen is received fresh from the O.R. and labeled "uterus, cervix, ovaries, bladder". It consists of urinary bladder, uterus, cervix, and bilateral ovaries and fallopian tubes measuring overall 33 x 16 x 4 cm. The attached peritoneum measures 33 x 12 x 0.1 cm, which is smooth and glistening. The perivesical resection margin is inked black. The urinary bladder is opened anteriorly to reveal fungating papillary lesion in the upper posterior urinary bladder wall. The mass measures 5.5 x 3.5 x 1.5 cm. The remaining mucosa of the urinary bladder is red-tan in color.  The right ureter measures 8 cm in length and.
+
+--- Page 4 ---
+Page 4 of 6 Ordered 0.8 cm"in circumference, and the left ureter measures'7 cm in length and 0.8 cm in circumference.  Both ureters are grossly unremarkable. Bilaterally, the ureterovesical junction is 2.5 cm inferior to the tumor. The uterus measures 8.5 x 5 x 3.5 cm and is covered by an unremarkable serosa.  The cervix measures 2.5 cm in length and 2.5 cm in diameter. The external cervix is smooth and glistening. The. uterus is opened to reveal unremarkable endocervical cavity and endocervical canal. The endocervical canal measures 3 cm in length and o.5 cm in circumference.  The endometrial cavity measures 3.5 x 3 cm.  The endometrium measures 0.1 cm and the myometrium measures 1 to 1.5 cm in thickness.  The right fallopian tube measures  The right ovary measures 3 x 2 x 1 cm. The left fallopian tube measures 9 cm in length and 0.5 cm in diameter.  The left ovary measures 3 x 1.8 x 0.7 cm.  The bilateral adnexa are grossly unremarkable. piece of vaginal mucosa is also identified measuring 8 x 7 x 0.1 cm and is uninvolved by tumor grossly. Representative sections are submitted in a total of 34 cassettes.  The specimen is received in formalin and labelled "Lt. para aortic L.N.". It consists of a piece of tan soft tissue measuring 3 x 0.8 x o.4 cm. The specimen is entirely submitted in three cassettes. G: The specimen is received in formalin and labelled sRight para caval L.N.". It consists of a piece of tan soft tissue measuring 3 x 0.6 x o.2 cm. The specimen is entirely submitted in two cassettes. H: The specimen is received in formalin and labelled "Rt. common iliac L.N.". It consists of a piece of tan soft tissue measuring 3 x 1.5 x 0.2 cm. The specimen is entirely submitted in three cassettes. I: specimen is entirely submitted in three cassettes.. J: The specimen is received in formalin and labelled "Rt. L.N. of cloquet". It consists of a piece of tan soft tissue measuring 1.2 x 0.6 x 0.4 cm. The specimen is entirely submitted in one cassette. K: The specimen is received in formalin and labelled "Rt external iliac L.N.". It consists of multiple tan-yellow fibroadipose tissue fragments measuring 3 x 1 0.4 cm in aggregate. The specimen is entirely submitted in four cassettes. L: The specimen is received in formalin and labelled sRt. obturator / hypogastric L.N.". It consists of multiple tan soft tissue fragments measuring 4 x 1'x o.4 cm in aggregate. The specimen is entirely submitted in five cassettes. M: The specimen is received in formalin and labelled "Lt. external iliac L.N.n It consists of multiple tan soft tissue fragments measuring 3 x 1.5 x 0.4 cm in. aggregate. The specimen is entirely submitted in five cassettes. N: The specimen is received in formalin and labelled "Lt. L.N. of cloguet". consists of a piece of tan soft tissue measuring 1.8 x 1.2 x 0.4 cm. It The specimen is entirely submitted in one cassette. 0: The specimen is received in formalin and labelled "Lt. obturator / hypogastric L.N.". It consists of multiple tan soft tissue fragments measuring 3 x 2'x 0.8 cm in aggregate. The specimen is entirely submitted in four cassettes. P:  The specimen is received in formalin and labelled "Rt. pre-sciatic L.N.". consists of right presciatic lymph node. It It consists of multiple tan soft adipose. tissue fragments measuring 1.5'x 0.4 x 0.3 cm. The specimen is entirely submitted in one cassette.
+
+--- Page 5 ---
+Page 5 of 6 Q: The specimen is received in formalin and labelled "pre sacral L.N.". It consists of a piece of tan soft tissue measuring 4 x 1.5 x 0.2 cm. The specimen is entirely submitted in three cassettes. R: The specimen is received in formalin and labelled "Lt. pre sciatic L.N.". consists of  multiple tan soft tissue fragments measuring 0.8 x 0.6 x 0.2 cm in It aggregate. The specimen is entirely submitted in one cassette. s: The specimen is received in formalin and labelled "Lt proximal ureter". It consists of a portion of ureter measuring o.4 cm in length and o.4 cm in diameter. The specimen is entirely submitted in one cassette. T: The specimen is received in formalin and labelled "Right medial proximal. margin of ureter". It consists of a portion of ureter measuring 0.6 cm in length and~o.4 cm in diameter. The specimen is entirely submitted in one cassette. U:  The specimen is received in formalin and labelled "Right internal proximal ureteral margin". It consists of a portion of ureter measuring 0.3 cm in length. and 0.4 cm in diameter. The specimen is entirely submitted in one cassette. V: The specimen is received in formalin and labelled "Isolated lymph node". It consists of a lymph node measuring 1.8 x 0.8 x 0.6 cm. The lymph node is bisected and entirely submitted in one cassette. SECTIONS : AFS: frozen section, right M F/S Bes: frozen section, right L F/S c: right distal ureter'- all embedded. Des: frozen section, left distal ureter F/S. E1: urethral margin E2 : anterior bladder wall E3 : right lateral bladder wall E4 : right ureterovesical junction E5: dome E6: posterior urinary bladder wall E7: trigone to urethra E8: left lateral urinary bladder wall E9 : left ureterovesical junction E10,11: full thickness tumor to vaginal mucosa E12-15: tumor E16: vagina E17: anterior cervix E18: posterior cervix E19: anterior endomyometrium E20: posterior endomyometrium E21: right adnexa E22 : left adnexa E23-26: right perivesical fat for lymph node E27-30: left perivesical adipose tissue for lymph node E31-34 additional sections of the tumor F1-3: left para-aortic lymph node - all embedded G1,2: right paracaval lymph node - all embedded. H1-3: right common iliac lymph node - all embedded I1-3: left common iliac lymph node - all embedded J: right lymph node of cloquet - all embedded K1-4: right external iliac lymph node - all embedded. L1-5: right obturator/hypogastric lymph node - all embedded M1-5: left external iliac iymph node - all embedded N: left lymph node of Cloquet - all embedded
+
+--- Page 6 ---
+Page 6 of 6 erder 01-4: left obturator / hypogastric lymph node - all embedded P: right presciatic lymph node - all embedded Q1-3: presacral lymph node - all embedded. R: left presciatic iymph node - all embedded. s: left proximal ureter - all embedded T: right medial proximal margin of ureter - all embedded U: right internal proximal ureteral margin - all embedded v: isolated lymph node - all embedded. INTRAOPERATIVE FROZEN CONSULTATION: Afs:  Right medial ureter: negative BFs: Right lateral ureter : negative DFs: Left distal ureter: negative INTRAOPERATIVE GROSS CONSULTATION E: BLADDER TUMOR PRESENT WITH GROSSLY FREE MARGINS MICROSCOPIC EXAMINATION: A-D  See final microscopic-diagnosis. E:  Sections show an invasive papillary urothelial carcinoma infiltrating into the. deep layer of the muscularis propria, but not through it (E34). Multi foci of. high grade urothelial carcinoma in situ are identified (E2, 6, 8). There are. suggestive of lymphovascular invasions noted. All the surgical margins are free of malignancy. No metastatic urothelial carcinoma identified in five perivesical. lymph nodes (0/5) examined. Sections of the uterus show chronic cervicitis with squamous metaplasia, weakly. proliferative endometrium. Bilateral ovaries display physiologic changes and bilateral fallopian tubes are unremarkable.. G-v: See final microscopic-diagnosis..
\ No newline at end of file
diff --git a/output/text/0d0364c4-e001-41f7-b420-f88aca5f77f1.txt b/output/text/0d0364c4-e001-41f7-b420-f88aca5f77f1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..00e3bc6767f28428a19d68e46cded6e56bc77e13
--- /dev/null
+++ b/output/text/0d0364c4-e001-41f7-b420-f88aca5f77f1.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:A8980EE8-52DE-4DA5-84DD-F8E86E3F6A9B TCGA-OL-A5D7-01A-PR Redacted Sample # T cD o -3 Carcinomo-, Inf, /traIug Duct No I 85odJ3 Surgical Pathology Report S,te: OBreast, NbS C5s9 * Amended * M2/24/10 FINAL PATHOLOGIC DIAGNOSIS Lumpectomy and sentinel lymph node biopsy, left breast and axilla: A. Sentinel lymph node #1, left axilla:. - Single lymph node, no tumor (0/1). B. Left breast lumpectomy: - Invasive ductal carcinoma, SBR grade III, with focal necrosis and associated 1ymphocytic infiltrate. See parameters below. - Ductal carcinoma in situ, solid type, high nuclear grade, associated with invasive carcinoma. - Unremarkable uninvolved breast parenchyma. Breast Pathologic Parameters 1. Invasive carcinoma:. A. Gross measurement: 2.8cm B. Composite histologic (modified SBR) grade III - Architecture: 3 - Nuclear grade: 3 - Mitotic count: 3 C. Associated ductal carcinoma in situ (DCIS): high nuclear grade, <5% of tumor volume, associated with invasive carcinoma. 2. Excisional biopsy margins: Free of tumor - DCIS >1 cm from nearest margin. - Invasive carcinoma 7mm from posterior (closest) margin 3. Blood vessel and lymphatic invasion: Absent 4. Axillary lymph nodes: Negative for tumor 5. Special studies (performed on current material):. - No reactivity for ER (no staining). - No reactivity for PR (no staining) - Her2/neu (FISH) is pending. 6. pTNM: pT2, N0(sn), MX. Clinical History: year-old female with a left breast cancer undergoing left breast sentinel lymph node biopsy and partial mastectomy..
+
+--- Page 2 ---
+Specimens Received: A: Left axillary sentinel lymph node #1 B: Left breast partial mastectomy Gross Description: Specimens received in two containers each labeled with the patient' s name and medical record number. A. Part A is additionally designated 'left axillary sentinel lymph node #1.' Received fresh for frozen diagnosis is a 2.4 x 1.3 x 0.9 cm lymph node which is bisected. Half of the lymph node is frozen and read as no carcinoma per Dr. Chang. The remnant of frozen tissue is entirely submitted in cassettes A1FS. The remnant of non-frozen tissue is submitted in cassette A2.. Part B additionally designated '2 left breast partial mastectomy double short stitch superior, double long lateral'. Received fresh and placed in formalin is a 114 gm partial mastectomy specimen. The measurements are as follows: Superior to inferior 7.0 cm, medial to lateral 9.8 cm, and anterior to posterior 4 cm. There is skeletal muscle on the posterior aspect of the lumpectomy specimen measuring 3.8 x 1.5 cm. The specimen is inked as follows: Superior blue,. inferior green, posterior red, anterior black, lateral purple and medial yellow. The specimen is serially sectioned from medial to lateral and to 11 slices. There is a 2.8 x 2.5 x 2.4 cm well-circumscribed firm tan-pink mass which demonstrates focal hemorrhage. This mass is 1.1 cm from the inferior margin, 0.7 cm from the posterior margin, 3.5 cm from the superior margin, 1.1 cm from the anterior margin, 2.2 cm from the lateral margin and greater than 5 cm from the medial margin.. B1-B2: medial margin. B3-B7 lateral margin. Clearly sectioned and entirely submitted. B8-B10 : representative sections of mass from slice 7 demonstrating relationship to red ink margin (posterior) B11: representative site of section of mass in slice 8 showing relationship to green margin. B12: representative section of slice 8 showing skeletal muscle on posterior aspect B13-B15: representative sections of mass in slice 9 showing relationship to red.. green, and black inked margins. B16: representative section of slice 9 demonstratingskeletal muscle at closest approximation to mass. B17: representative section of normal breast parenchyma, site unspecified
+
+--- Page 3 ---
+B18: normal breast parenchyma slice 3 B19: normal breast parenchyma slice 7. Intraoperative Consult Diagnosis: A1FS. Left axillary sentinel lymph node #1: No carcinoma
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diff --git a/output/text/0d0d2944-33f5-4378-a023-f7fe1a3faf0b.txt b/output/text/0d0d2944-33f5-4378-a023-f7fe1a3faf0b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d34453aed397fa854d9fbd5c8fd4a7d615b28241
--- /dev/null
+++ b/output/text/0d0d2944-33f5-4378-a023-f7fe1a3faf0b.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UUID:CD438A31-A5C6-4C0C-AA07-3171332776CC0 TCGA-C8-A278-01A-PR Redacted Irr aDc^nvfD iu -. - Form F Clinical Case Report 1cs-0-3 (For Collection of Cancerous Tissue) Carciomt infiltreting duct, Nos 8500/3 S1t2 buaot,Nos C5o.9 524 Informed Consent I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator Signature Date Clinical Information GENERAL INFORMATION Date of Birth (mm/dd/yyyy) Height Marital Status Race. Temperature Single Married Gender Weight  Widow  Divorced Blood Pressure Heart Rate 131  Male Female HISTORY OF PRESENT ILLNESS Chief Complaints: livnp in the Ceff beas! j pinhu. Symptoms: Clinical Findings: A tu^mouf Uag f0unl inUhe tff Ineasf Performance Scale (Karnofsky Score):  80-90 Symptomatic but Fully Ambulatory ~60-70 Symptomatic, in bed less than 50% of day  100 Asymptomatic  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden.  20-30 Bed Ridden CURRENT MEDICATIONS Drug Dose Route Freguency Date (mm/dd/yyyy) To 1 To / / To / To To
+
+--- Page 2 ---
+PAST MEDICAL HISTORY  Dlagnosis Date Treatment Status Diagnosis/Disease/Disorder/Injury OB/GYN HISTORY Date of First Menses # of Pregnancies Menopausal Status 02  Pre-menopausal Yeass aLc Date of Last Menses # of Live Births /Peri-Menopausa! 08  Post-menopausal  Oral Contraceptive IUD  Hormone Replacement Birth Control:  Condom Therapy:  Other: SOCIAL HISTORY Environmental Hazards: Occupation: Smoking History Duration When Quit Current Status TYPE Packs/day (yrs) (yr) OYES ANO Alcohol Consumptlon  Drinks/day Duration When Quit Current Status TYPE (yrs) (yr)  yes 4NO Drug Use Duration When Quit Current Status TYPE Frequency (yr)J gNO (yrs)]  yes FAMILY MEDICAL HISTORY Age of Diagnosis Relative  Diagnosis LAB DATA Result Date Date Test Test  Result CEA  Negative  Positive: HIV Negative  Positive: CA 15-3  Negative  Positive: Negative  Positive: Hep B CA 19-9  Negative  Positive:  Positive: Hep C  Negative PSA   Negative  Positive: AFP Negative  Positive: Other: Other:  Negative  Positive:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+DIAGNOSTIC STUDIES Study Resuits Date Ultrasound X-Ray cT Endoscopy MRI Biopsy Acenocrcinmeg CLINICAL DIAGNOSIS Preoperative Clinical Diagnosls L.BREAST CANCER Location of Suspected Involved Lymph Nodes Location of Suspected Distant Metastasis Clinical Staging Date of Diagnosis. T3 Na MO Stage: IB Treatment Information SURGICAL TREATMENT Procedure Date of Procedure Modihed Radisal Mastortrne  Primary Tumfor Organ Detailed Location Size BReasTTimoR Jeet k x5~x3 cm Extension of Tumord Lymph Nodes Description Location of Lymph Nodes. # of Lymph Nodes. Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis  Organ Detailed Location  Size Surgical Staging T3No M o. Stage: T B  NEOADJUVENT THERAPY (Chemo, Radiation, Immuno, Hormonal, or Molecular) Dose Route Frequency Date (mm/dd/yyyy) Drug/Treatment To To 1 1 1 To 1 To 1 To 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Date Collected by: Date ime Preserved by: SPECIMEN TYPE (# of samples provided)  Blood/Serum/Plasma Slide Frozen  Paraffin Block Normal Diseased Normal Normal Diseased Norma! Diseased Diseased Z 4 Z Z Time to Formalin Time to LN2 Time to LN2 min min min 73 PATHOLOGICAL DESCRIPTION Primary Tumor Size Extenslon of Tumor Distance to NAT Organ 5 6 x5 x3 cm kpper crler grac(rru cm Breas! Tuniax Teel Lymph Nodes # Metastasized # Examined Location Distant Metastasis  Detailed Location Size Organ Pathological Staging m 0 Stage: I3 pT 3 No Notes: Mj(-) Mz(-)
+
+--- Page 5 ---
+ConsolIdated Diagnostic patholOgy fOrm* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION  Diffuse + . STRUCTURALPATTERN  Mosaic K Streaming Necrosis X Storiform Lymphocytic Infiltration Fibrosis Vascula Invasion X Palisading Clusterized X Cystic Degeneration Alveolar Formaxion Y Bleeding Indian File Y Myxoid Change 2. Cellular Seatures: Y Psammoma/Caicification Sowamous. +Adenomatous Souamoid Cell +  Sarcomatous Glandular cell Lymphomatous Round Cell Spindle Cell Cell Stratification Large Cell Fibroblast Keratin Small Cell Secretion Osteoblast  Desmosome RS Ccll/RS Like Intracyt. Vacuole  Lipoblast Inflam. Cell Pear!  Gland formation Myoblast Plasma Cell Otherwise Specified: 7s% 027SZ D37oZ >4ZS% 2.Cellular Differentiation: Well Moderately Poor 3. Nuclear Atypia: Nuckear Appearance Aniso Nucleosis Hyperchromatism Nucleolar Prominent ? Multinuclcated Giant Cell Mitoxic Activity Nuckear Grade Histological Diagnosis:nhltxe kas hetal CenhYry, Nos jo-) M,M, : C(Ron. Lymshadeuib, lcfexxed Comments:. Date Director, Research Pathology PATHOLOGIST STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CONTRISUTOR AND
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diff --git a/output/text/0d13653e-63ce-49cb-bbfe-2c97348aa9d0.txt b/output/text/0d13653e-63ce-49cb-bbfe-2c97348aa9d0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0a4eb6ea0f788fe864e1181898e400a837101ebc
--- /dev/null
+++ b/output/text/0d13653e-63ce-49cb-bbfe-2c97348aa9d0.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+FINAL DIAGNOSIS: Part 1: Lymph nOde, right AxilLAry Sentinel #1, BIOpsy anD frozen SectiOn -- One Lymph nODe, free Of tumor (0/1). Part 2: Lymph nOde, Right AxilLAry Sentinel #2, BiOpsy And frozen SectiOn -  micrometastatic ADenOcarcinoma involviNg One Out Of TwO Lymph nOdes (1/2), up tO 1.5 mm (2 FS2) (see comment). 1CD -0 -3 Part 3: breast. Right, total mastectomy -- Carcima, infiltrshing ouchl nss 850of: A. InFIltrating DuctaL CarcinomA ;Sih; brust,nrs C5o.9 3f/3|u pu B. The TUmOR Size iS 2.7 X 2.5 X 2.4 CM. C.  NOtTinghAm SCOrE iS 9/9 (tubuLeS 3, nUclEAR 3, mItOSES 3).  EXTeNSIVE LymPhOVASCULAR InVASION IS PRESENT. E. DUCTAL CARCINOMA IN-SITU, SOLID AND CRIBRIFORM TYPES, NUCLEAR GRADE 3, WITH COmEDONECROSiS, ASSOCIATED MICROCALCIFICATIOn AND RETROGRADE CANCERIZATION OF LOBULES, PRESENTING ABOUT 5% OF TUMOR VOLUME. F.  DUCtAL CARCInOmA In-SITU iS PRESEnt ADmIXED AND OUTSIDE OF inVASIVE TUmOR. G. MArGinS Of RESECTIOn ArE fREE Of TUmOR. H. NIppLe, no tumor is Seen. I. SKIn, nO tUmOR IS Seen. J. ChAngeS COnSIStenT WiTh PReVIOUs BiOpSy SiTE, SEE PRIOR K. ATYPICAL DUCTAL EPITHELIAL HYPERPLASIA. L FIBROADENOMA AND FIBROADENOMATOID NODULAR CHANGES. M. FiBROCYSTiC CHAnGES WITH COLUMNAR CELL CHANGES, DUcTaL EPITHELIAL HYPERPLASiA AND ASSOCIATED MICROCALCIFICATIONS. N. MICROSCOPIC CAPILLARy HEmAnGIOmA. O.  MEDIAL CALCIFICATION OF BLOOD VESSEL. p.  IMMUNOHiSTOCHEMICAL STAINING FOR ESTROGEN RECEPTOR, PROGESTERONE RECEPTOR AND HER- 2/NEU ARE BEING PERFORMED ON PREVIOUS SPECIMEN AnD RESULTS ARE PENDING. COMMENT: Part 2: The above measurement of the micrometastatic tumor within the lymph node is made on the slide .. original frozen section slide was re-reviewed with Dr.. The  and there was no diagnostic changes identified. Part 3: Immunohistochemical staining for e-cadherin/p120, support the ducta! phenotype of the carcinoma in situ. UUID:0D76394C-40B4-4E74-8A80-FAE00E21FD10 CGA-BH-A0BF-01A-PR Redacted
\ No newline at end of file
diff --git a/output/text/0d34b719-9668-4233-9bd4-200c0645a5be.txt b/output/text/0d34b719-9668-4233-9bd4-200c0645a5be.txt
new file mode 100644
index 0000000000000000000000000000000000000000..299cd917900cc13f8f2f8390f8cc4f858c6fb2f6
--- /dev/null
+++ b/output/text/0d34b719-9668-4233-9bd4-200c0645a5be.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+CGA-A6-2683 SPECIMEN A. Right colon. B.  Liver biopsy CLINICAL NOTES PRE-op DiagnosIs: Ascending colon cancer. GROSS DESCRIPTION A. Received fresh for tissue procurement, labeled "right. colon", is a previously unopened, 12 cm segment of proximal right colon with attached 6 cm of distal ileum surfaced by smooth to scabrous tan-pink serosa with a moderate amount of attached mesocolon and mesentery. An unremarkable 5.7 cm appendix averaging 0.65 cm in diameter is present. The proximal and distal margins measure 7.5 and 6 cm in circumference respectively. On opening, there is a circumferential, 8.5 x 6.5 cm tumor mass extending from the ileocecal valve into the colonic segment. The tumor is present within 7 cm of the distal margin. On sectioning, the tumor has a maximal thickness of 1.2 cm, grossly extending into the muscularis to within 0.4 cm of the inked free radial serosal surface (see blue blocks 2-4). The uninvolved ileal and colonic mucosa is. unremarkable, glistening tan-pink-red with irregular folds and the. walls average 0.5 cm in thickness. A portion of tumor and a. portion of normal mucosa are submitted for tissue procurement as requested. Several soft to slightly rubbery pale tan tissues in keeping with lymph nodes measuring up to 1.2 cm in greatest dimension are. recovered from the attached mesocolon and mesentery. Representative sections are submitted in 13 blocks as labeled. Rs-13. BLOck suMmARy: 1 - Proximal and distal margin; 2-4 - tumor to inked free radial serosal surface; 5 - central tumor; 6 - tumor at IcD; 7  random ileum and colon; 8 - appendix; 9, 10 - eight whole lymph nodes per cassette; 11 - seven whole lymph nodes; 12, 13 - one bisected lymph node per cassette.
+
+--- Page 2 ---
+GROSS DESCRIPTION B. Received in formalin, labeled "liver biopsy", is a core biopsy of white tissue that measures 2 x 0.2 x 0.2 cm. in. dimension. The tissue is entirely submitted for permanent section. in cassette labeled B. AS-1 MICROSCOPIC DESCRIPTION  This right hemicolectomy specimen has an infiltrating adenocarcinoma beginning at the ileocecal valve and extending into the colon. Please see the template below: Histologic type: Infiltrating adenocarcinoma. Histologic grade: Moderately to poorly differentiated. Primary tumor (pT): Tumor extends to the visceral peritoneum, pT4. Proximal margin: Negative for tumor. Distal margin: Negative for tumor. Circumferential (radial) margin: Negative for tumor. Distance of tumor from closest margin: The tumor is 7 cm. from the distal margin. Vascular invasion: Not detected. Regional lymph nodes (pN): All 25 regional lymph nodes are negative for metastatic disease, 0/25, pN0. Non-lymph node pericolonic tumor: Negative. Distant metastasis (pM): As per part B, metastatic disease is present in the liver, pM1. Other findings: Appendix, no significant pathology. B. This core of tissue is composed entirely of metastatic,. moderately to poorly differentiated adenocarcinoma consistent with colonic origin. There is a markedly desmoplastic stroma. No residual hepatic parenchyma is present.
+
+--- Page 3 ---
+MICROSCOPIC DESCRIPTION 5, 4 DIAGNOSIS A. Right colon, right hemicolectomy - Moderately to poorly differentiated adenocarcinoma of the right colon, extending deeply into pericolonic fat and to the inked serosal peritoneal surface. All other margins and all 25 regional lymph nodes are negative for tumor. Appendix and portion of terminal ileum, no significant pathology. B. Liver, core biopsy - Moderately to poorly differentiated adenocarcinoma consistent with metastasis from colonic primary.
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diff --git a/output/text/0d4f35c7-b1e6-430f-b311-ef9f0aeac0fe.txt b/output/text/0d4f35c7-b1e6-430f-b311-ef9f0aeac0fe.txt
new file mode 100644
index 0000000000000000000000000000000000000000..205834b470d50150d3308c05fbeeba4519279c3f
--- /dev/null
+++ b/output/text/0d4f35c7-b1e6-430f-b311-ef9f0aeac0fe.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SPECIMEN A. Apical lymph nodes B. Sigmoid and upper rectum C. Appendix CLINICAL NOTES PRE-OP DIAgNosIS: Rectal cancer. GROSS DESCRIPTION A. Received in formalin labeled "apical lymph node" is a. 0.8 x 0.5 x 0.3 cm yellow fatty tissue fragment which may be possible lymphoid tissue. The tissue is entirely submitted in one cassette. B. eived fresh subsequently fixed in formalin labeled "sigmoid and upper rectum". The specimen grossly consists of a 20-cm long portion of colon which is stapled at the distal end. (inked black) and opened at the proximal end (inked blue). The serosa of the specimen is pink-tan smooth and glistening partially covered with abundant yellow lobular fat. Retroperitoneal. reflection is located 6 cm from the distal margin. The specimen is opened to show a pink-tan smooth glistening mucosa with an average circumference of 5.5 cm. There is a large exophytic tumor closer to the distal end, measuring 5.3 x 6.0 x 1.0 cm.. This is located 3.5. cm from the distal end. The distal end has a circumference of 7.5 cm and the tumor comes within 0.6 cm of being circumferential. The. cut surface of the tumor shows invasion into the muscularis propria. However, no discrete invasion is grossly identified into the fat. This comes within 2.5 cm of the radial margin. A sample was taken for tissure procurement. The remainder of the mucosa is pink-tan smooth and glistening with normal to slightly dilated folds. No other discrete gross lesions are identified in the mucosa. Multiple. lymph nodes are grossly identified in the fat which are firm and somewhat enlarged up to 1.7 cm in greatest dimension. Representative sections of the specimen are submitted as follows: Block 1 - representative luminal margin; block 2-4 - representative. section of tumor which includes tumor to normal and tumor into fat; block 5 - representative radial margin; block 6 - one possible. lymph node bisected; block 7-15 - whole possible lymph nodes. C. The specimen consists of a 5.5 x 0.7 cm app. which is partially covered pink-tan smooth glistening serosa and minimally yellow lobular fat. The specimen is sectioned to show an. intact wall with an average thickness of 0.3 cm. The lumen ranges from pinpoint to 0.3 cm partially filled with green feces.. Representative sections of the specimen tted in one cassette with the proximal end inked..
+
+--- Page 2 ---
+MICROSCOPIC DESCRIPTION A. This single apical node is negative for metastatic. disease, 0/1. B. This segment of colon contains an ulcerated,. moderately differentiated adenocarcinoma, minimally extending into pericolonic fat. Please see the template below:. Histologic type: Infiltrating adenocarcinoma. Histologic grade: Moderately differentiated. Primary tumor (pT): pT3. Proximal margin: Negative for tumor. Distal margin: Negative for tumor Circumferential (radial) margin: Negative for tumor.. Distance of tumor from closest margin: The tumor is 3.5 cm from the distal margin. Vascular invasion: Not detected. Regional lymph nodes (pN): As per parts A and B, a total of 48 lymph nodes are found, one of which contains metastatic disease, 1/48, pN1a. Non-lymph node pericolonic tumor: Negative. Distant metastasis (pM): Cannot be assessed. C. Microscopic examination performed. 3,5,1 DIAGNOSIS A. Apical lymph node, excision -. Single lymph node negative for metastatic disease, 0/1. B.  Sigmoid and upper rectum, segmental resection Segment of colon with infiltrating, moderately differentiated adenocarcinoma, extending into pericolonic fat.. All margins are negative for tumor. Metastatic disease is present to 1 of 47 lymph nodes, 1/47. C. Appendix, appendectomy - Appendix - no significant pathology.  End Of Report -
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diff --git a/output/text/0d6e8f63-8036-4564-89f5-b83fe6272c8b.txt b/output/text/0d6e8f63-8036-4564-89f5-b83fe6272c8b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..871ab7c444f01e5f2c23baf80b7e0f193ba32c6e
--- /dev/null
+++ b/output/text/0d6e8f63-8036-4564-89f5-b83fe6272c8b.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID: 8866FD87-4F6F-4D7E-B99A-70D427ED3883 TCGA-OR-A51-01A-PR Redacted Dellver To: : 1 1 tcD-6-3 Tmsr Alreral Cirtica SPECIMEN TYPE: Adrenal Biopsy No: Site: @Ad rmalGland T Cortex C74.O CLINICAL NOTES: H Histopathology of L) adrenal gland. Conn's syndrome (note small section of g) (/3o) 13 tumour excised for genetic studies). 0 L MACROSCOPIC: "Left adrenal.* The specimen consists of an adrenal gland with a post fixation 0 weight 102.4g. It measures 110 x 70 x 60mm. A section of tissue has been G taken trom one pole. On sectioning, a nodular lesion with a maximum diameter Y of 25 x 30rmm, and extending for a length of 70mm, can be identified. The cut surface of this lesion is irregular. It can be seen to be compressing the adjacent normal adrenal tissue. Block 1: tissue near the excision where previous sampling for genetic studies has already been performed. Blocks 2 and 3: lesion where it abuts the normal adrenal gland. Block 4: lesion with its closest proximity to the excision margin. Blocks 5-9 : further blocks of lesion. MICROSCOPIC: Sections show an adrenal tumour with a predominantty trabecular architectural A pattern and demonstrating a mitotic rate of <6 per 50HPF. Cytological atypia is N present. No absolutely definite vascular invasion is seen. The tumour appears close but clear of the painted excision margin. A The morphological appearances of this adrenal tumour in association with the results of immunoperoxidase stains (ie. positive for vimentin and negative for T Cam 5.2 and chromogranin) are consistent with a cortical adrenal tumour, which 0 is considered best regarded as an 'adrenal cortical neoplasm of indeterminate  malignant potentiai", and continuing long-term clinical follow-up Is strongly M recommended. 1 SUMMARy: Considered best regarded as an *adrenal cortical tumour ot C indeterminate malignant potential. A Note: Please see attached references from Tumours of the Adrenal Gland and L Extra-Adrenal Paraganglioma by Ernest E.Lack: No 19 - 3rd series; from the Armed Forces institute of Pathology, Washington D.C. P T-93000 M-09350 A ADDITIONAL REPORT: T ELECTRON MICROSCOPY: (received from 4 0 L pano 1 af  0
+
+--- Page 2 ---
+Requesting Doctor's Informatlon: Deliver To: A T SPECIMEN TYPE:  Adrenal Biopsy No: H "The majority of cells examined by electron microscopy show the features of 0 aldosterone-secreting tumours. In particular, mitochondria elongated with numerous lamellar cristae ("sarcotubular" mitochondria), similar to those of L the normal zona glomerulosa. However, spherical "hybrid" mitochondria with 0 lamellar or tubular cristae are also seen. Rough and smooth surfaced G endoplasmic reticulum are present In moderate amounts. Lipid droplets are sparse. A tew pleomorphic nuclei were seen, but the majority appear spherical Y with a regular chromatin pattern and a small nucleolus. Most authorities agree that it is not possible to predict the likely behaviour of adrenal cortical tumours from their ultrastructural appearances. Reliance should be placed on the usual histological and macroscopic criteria." A REPORTING PATHOLOgIST: N (Electronic Signature) A T 0 M c A Process - ship an holul. L IN detumwant maluynut poTenhiel " P W18113 A T AUALIFIE H 0 L 0 Page 2 of 2 G Y
\ No newline at end of file
diff --git a/output/text/0da2fd64-2545-4907-bbbd-7c56e8fba5a5.txt b/output/text/0da2fd64-2545-4907-bbbd-7c56e8fba5a5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..cc116cd6b56fbca9523f2e72a4d7689b2cc0a2f9
--- /dev/null
+++ b/output/text/0da2fd64-2545-4907-bbbd-7c56e8fba5a5.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Formatted Path Report Colon segment up to 17 cm long with Adenocarci the tumor of 9 cm in its largest noma; G2; dimension; fatty tissue lymph nodes. fatty are small, their observation is not. tissue enough informative.. infiltration. Lymph nodes demonstra te reactive changes.
+
+--- Page 2 ---
+Tumor Features: Ulcerated, Tumor LARGE INTESTINE TISSUE CHECKLIST Extent: Fat, NOs, Venous Invasion: Absent, Margins: Absent, Treatment Specimen type: Sigmoid colectomy Effect: Specimen size: Not specified Tumor site: Sigmoid colon Tumor size: 0 x 0 x 9 cm Tumor features: Ulcerated Histologic type: Adenocarcinoma Histologic grade: Moderately differentiated Tumor extent: Pericolonic tissues Lymph nodes: 0/12 positive for metastasis (Adjacent fatty tissue 0/12) Margins: Not specified Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None
\ No newline at end of file
diff --git a/output/text/0dcf5926-ae5f-4f36-aae7-c6a51ed1cf84.txt b/output/text/0dcf5926-ae5f-4f36-aae7-c6a51ed1cf84.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7d71c6eb5ee8cddab5d84057c70c59bfe09ef242
--- /dev/null
+++ b/output/text/0dcf5926-ae5f-4f36-aae7-c6a51ed1cf84.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:D77DF136-6F63-48B7-8187-6F8F98CC1F44 TCGA-D8-A4Z1-01A-PR Redacted Department of Cancer Pathology Gender: F Examination result Jc0-0-3 Caco,n, lif2truHng 1obulv,Nrs 85stf3 Clinical diagnosis (suspicion): ca mammae dex. Sitr susst, Nos c5o.9 71(4/1) Material: 1) Material: right breast with tumour (+possibly with AXILLARY LYMPH NODES DEPENDING ON THE EXAM. RESULT). Method of collection: Breast with no lymph nodes (mastectomia simplex) Histopathological Diagnosis: Including test No. Invasive lobular carcinoma and lobular carcinoma in situ of the right breast. (NHG2, pTlc, pN 0 (sn)). (8520/3 Macroscopic description: Right breast, sized 20.4 x 13.8 x 4.6 cm, removed without armpit tissues and with a skin flap of 19.4 x 8.6 cm. Weight 540 g. Tumour sized 1.6 x 1.4 x 1.6 cm in the inner lower quadrant, placed 2.1 cm from the lower edge, 1.6 cm from the base and 0.9 cm from the skin. Microscopic description: Invasive lobular carcinoma - NHG2 (3+2+ 1/0 mitoses/10 HPF - visual area 0.55 mm) and lobular carcinoma in situ with nuclear atypia < 10% of the tumour). Glandular tissue showing fibrocytoid lesions adenosis, usual ductal hyperplasia, fibroadenoma. Invasive lesions removed 1.6 cm from the base.. Assistant: Result of immunohistochemical examination Estrogen receptors found in 75% of neoplastic cell nuclei.. Progesterone receptors found in 10-75% of neoplastic cell nuclei HER2 protein stained with Ventana's Pathway HER-2/neu (4B5) Rabbit Monoclonal Antibody Negative reaction in invasive cancerous cells ( Score = 1+). The expression of proliferating cell nuclear antigen Ki 67 in 10% cellular nuclei. Assistant: CONTACT YOUR DOCTOR WITH THIS L
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diff --git a/output/text/0dde2fee-d917-4811-8172-3e22518e7eed.txt b/output/text/0dde2fee-d917-4811-8172-3e22518e7eed.txt
new file mode 100644
index 0000000000000000000000000000000000000000..80242ac0d958a32fda0b21edac70d50e8c7a5fa9
--- /dev/null
+++ b/output/text/0dde2fee-d917-4811-8172-3e22518e7eed.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+ICD6-3 Carcinonic, adrenal cortica! UUID:31004530-E017-4913-A8AA-7AE709EAE0F1 8370/3 TCGA-OR-A5LS-01A-PR Redacted Site:  BAdr^exl C1avdQsrt4 C 74 0 O e/@/3 Procedure: Right adrenalectomy Gross description: tumor is 208g; measuring 9.3 x 8.7 x 5.5cm. Diagnosis: Based on paper from Bisceglia et al, this tumor is consistent with adrenal cortical carcinoma. Weiss score = 6. Chronic cholecystitis, colculosis (s/p) cholecystectomy).
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diff --git a/output/text/0e073fc0-623c-4791-8e50-be14d1b5e3be.txt b/output/text/0e073fc0-623c-4791-8e50-be14d1b5e3be.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5435dfdef5e58fc385a8934ec057e42da04829de
--- /dev/null
+++ b/output/text/0e073fc0-623c-4791-8e50-be14d1b5e3be.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:032881C5-F936-448E-A352-C186DF160B7C Procedure Date: TCGA-BH-A1FL-01A-PR Procedure Physician: Redacted Attending Physiclan/Copies To: PATIent hIStOry: + DATE OF LIP: DATE Or LAST DELIVERY: PRE-OP DIAGHOSIS: L BREAST CA, ABN MAMMO R BREAST POST-OP DIAGNOSIS: SAME OPERATIVE PROCKDURE: R SEGM MAST, L SEGM MAST, AXILL DISS CLINICAL HISTORY: MATERIAL SUEXKITTSD: A)   RIGHT BREAST BIOPSY/MASS/SEGMENTAL MASTECTOMY, PROCOREMENT BY SURGICAL PROCEDURE routine sutures : B) LEFT BREAST BIOPSY/MASS/SEGMENTAL MASTECTOMY, PROCUREMENT BY SURGICAL PROCEDURE routine sutures C) LEFT AXILLA, PROCUREMENT BY SURGICAL PROCEDURE INTRAOPERATIVE CONSULTATION: Left breast mass with_orientation. Breast tissue 7.0 x 7.5 x 2.5 cm, mass 2.8 x 1.5 x 1.8 cm. Margins grossly free. ER/pR taken.. FINAL DIAGNOSIS: FINAL DIAGNOSIS: A) RICHr BREAST TISSUE (7.0 BY 6.0 BY 1.7 CX): No CAvco - ATYPICAL DUCTAL SPITHELIAL HYPERPLASIA  MICROCALCIFICATIONS INTILTRATING DUCTAL CARCINCA) WITE EXTENSIVE LOBULAR FEATURES? INTERMEDIATE NUCLEAA GRADE TUMOR APPROACHES BUT DOES NOT ZXTEND TO ANTERIOR SURGICAL JOARCIN (<1 JMO) IM PLANES OF SECTION TUMOR APPROACHES BUT DOES NOT ZXTEND TO POSTERIOR SURGICAL MARCIN (<1 IM) IN PLANES OF SECTICN C) LEIT AXILLARY LYMPH NODES: NOTr: Two additional definitely positive lymph nodes were identified in deeper sections and with immunostaine (can 5.2) for a total of (4/22). This tumor is a T2nnmx c2. 1CD-0-3 cQCF: carcinoma; dGra1, N0S 850013 8523/3 hw 9/31f1 Site: busst, wos c.50.9 T55 verifie5 tissue from C breast
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diff --git a/output/text/0e9930c5-7688-425e-8a09-28475ad61d6c.txt b/output/text/0e9930c5-7688-425e-8a09-28475ad61d6c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3f14ad8e1514872e2dcc05e9182ba05bde55151d
--- /dev/null
+++ b/output/text/0e9930c5-7688-425e-8a09-28475ad61d6c.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+DIAGNOSIS: A.Kidney, left cyst wall, excision: Benign fibrous walled cyst. B.Kidney left partial nephrectomy Tumor Characteristics: 1.Histologic type: Papillary renal cell carcinoma. Tumor site: Left kidney. 3.Tumor focality:Unifocal. 4. Tumor size3.0 x3.0x 2.5 cm. 5.Microscopic extent of tumor: Tumor transgresses renal capsule into perinephric adipose tissue for a distance of approximately 0.1 cm. 6.Nuclear grade:Fuhrman grade 3/4. Lymphovascular space invasion: Not identified. 8. Sarcomatoid features: Not identified. Surgical Margin Status: Margins uninvolved by carcinoma: Tumor does not involve inked margin of resection. Other: pTNM stage:T3a NX. C. Specimen submitted as"tumor base #1", biopsy: Fibrous connective tissue with focus of atrophic tubules. No neoplasm identified. D.Kidneysuperior margin, biopsy: No neoplasm identified. E. Specimen submitted as "tumor base #2", biopsy: No neoplasm identified. F.Kidney lateral marginbiopsy No neoplasm identified COMMENTS: Histologic sections from the left kidney show a unifocal tumor mass measuring 3.0 cm in greatest dimension. Grossly the tumor appears to be limited to the kidney. However, there is an area in which there is microscopic transgression of the renal capsule with tumor extending approximately 0.1 cm into the perinephric adipose tissue. The tumor is not identified at the margins of resection. The tumor shows a papillary pattern consisting of polygonal to columnar shaped cells with enlarged oval nuclei and prominent nucleoli. Numerous clusters of macrophages are present within the papillary stalks. The histoloaic appearance is that of papillary renal cell carcinoma.
+
+--- Page 2 ---
+CLINICAL HISTORY: Preoperative Diagnosis: Postoperative Diagnosis: Symptoms/Radiologic Findings: SPECIMENS: A.Left cyst wall renal B. Tumor left kidney C. Tumor base #1 with frozen section D. Superior margin E. Tumor base #2 F.Lateral margin MOCARMRSPECIMENDATASOO GROSS DESCRIPTION: The specimen is received in six containers labeled with the patient's name, Container A is additionally labeled "cyst wall left renal and contains a 0.5 cm,tan-brown fibrous soft tissue. The specimen is wrapped in tissue paper and entirely submitted in cassette A labeled Container B is additionally labeled "tumor left kidney" and contains a 4.5 x 3.5 x 3.5 cm partial nephrectomy specimen featuring a cauteried margin on deep aspect and partially surfaced by yellow-tan perinephric fat on the superficial aspect.The fat is inked blue and the deep margin is inked black.The specimen is sectioned to reveal a 3.0 x 3.0 x 2.5 cm well circumscribed yellow-tan,hemorrhagic and variegated nodule that approaches to within 0.3 cm of the inked deep margin as well as 0.1 cm of the sunerfirial fat Normal appearing red-pink renal parenchyma is present at the base. Representative sections are submitted in cassettes B1-6 labeled all margins are perpendicular. Additionally,a yellow,green and blue cassette are submitted for genomics research, each labeled Container C is additionally labeled "tumor base"and contains a 0.4 cm, yellow-tan irregular soft tissue entirely submitted for frozen section with the residual entirely resubmitted for permanent section in cassette C labeled Container D is additionally labeled "superior margin" and contains a 4.0 x 1.0 x 0.4 cm portion of apparent kidney partially surfaced by a pink-tan capsule and perinephric fat. The exposed renal parenchyma is inked black and the capsule and fat is inked blue. The specimen is serially sectioned to reveal pink-tan,glistening cut surface with no discrete lesions. The specimen is entirely submitted in cassettes D1-3 labeled Container E is additionally labeled "tumor base" and contains two pink-tan, rubbery soft tissues, 0.5 and 0.9 cm in greatest dimension. They are entirely submitted in cassette E labeled ContainerF is additionally labeled lateral marginand contains a 2.5 x 1.0 x 0.4 cm,pink-tan,rubbery,irregular soft tissue. Entirely submitted in cassette F labeled INTRA-OPERATIVE CONSULTATION: FROZEN SECTION DIAGNOSIS PART C:Tubular atrophy with fibrosis per
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diff --git a/output/text/0f349a88-3710-4d6a-aef7-550366f2c8e2.txt b/output/text/0f349a88-3710-4d6a-aef7-550366f2c8e2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c53c0ffe269724e0fda8ad5d4c4759338195e1b3
--- /dev/null
+++ b/output/text/0f349a88-3710-4d6a-aef7-550366f2c8e2.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+E4492A1CBED TCGA- Redacted SURGICAL PATHOLOGY IcDo-3 Case Number : areynono) yeeyesla Diagnosis: renaQ eeQ0 8z6013 A: Kidney, left, partial nephrectomy Site OKuny No5 C64.9 Procedure: partial nephrectomy Laterality: left Histologic tumor type/subtype: papillary renal cell carcinoma, type II Sarcomatoid features: absent Histologic grade (if applicable): Fuhrman grade 2 Tumor size (greatest dimension): 4.5 cm (per gross examination) Tumor focality: unifocal Extent of tumor invasion (if present specify if macroscopic or microscopic): Capsular invasion/perirenal adipose tissue: absent Gerota's fascia: absent. Renal sinus: absent Major veins (renal vein or segmental branches, Ivc): not applicable Ureter: not applicable. Venous (large vessel): not applicable Lymphatic (small vessel): absent Histologic assessment of surgical margins: Renal parenchymal margin (partial nephrectomy only): negative (5 mm) Renal capsular margin (partial nephrectomy only): negative Paranephric adipose tissue margin (partial nephrectomy only): negative Adrenal gland: not submitted Lymph nodes: not submitted Pathologic findings in non-neoplastic kidney: Focal global glomerulosclerosis and mild interstitial nephritis.
+
+--- Page 2 ---
+AJCC Staging: pT1b pNx This staging information is based on information available at the time of this report, and is subject to change pending clinical review and additional information.. Clinical History: year-old male with a clinical diagnosis of a renal mass.. Gross Description: Received is one appropriately labeled container, additionally. labeled "left renal mass." It holds a 91.1 gram, 7.1 x 6.0 x 5.5 cm partial nephrectomy. The capsule is yellow, smooth and inked blue.. The parenchymal margin is tan/brown and inked black. Just beneath. the capsule, there is a roughly 4.5 x 4.2 x 2.6 cm partially solid,. partially cystic red/brown to yellow variegated mass. The mass abuts the capsule, but does not extend through it and comes to within 0.4 cm of the black inked parenchymal margin. No additional abnormalities are noted.. Block summary: Al-A2 - mass with closest approach to blue inked parenchymal margin, perpendicular A3-A4 - mass capsule, perpendicular A5 - parenchyma away from mass Tissue remains in formalin. Tissue is submitted to Tissue Procurement.. 13/13 H+11
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diff --git a/output/text/0f54867b-c506-41cc-a7d1-c2787d7ec947.txt b/output/text/0f54867b-c506-41cc-a7d1-c2787d7ec947.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7a91b21d949fd8491b1832815254e2506061a2cd
--- /dev/null
+++ b/output/text/0f54867b-c506-41cc-a7d1-c2787d7ec947.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Clinical Diagnosis & History: Colon carcinoma (hepatic flexure). Specimens Submitted: 1: sp: Terminal ileum, cecum, ascending colon; right hemicolectomy DIAGNOSIS: Sp: Terminal ileum, cecum, ascending colon; right hemicolectomy . Tumor Type: Mucinous adenocarcinoma Histologic Grade: Moderately disferentiated Tumor Location: Ascending colon Tumox Size Length is 6 cm Width is 10 cm Maximal thickneas is 1 cm Tumor Budding: Absent Increased Tumor Infiltrating Lymphocytes: Absent Precuxsor Lesions: Not identified Deepest Tumor Invasion:. Subserosal adipose tissue and/or mesenteric fat Gross Tumor Perforation:. Not identified Lymphovascular Invasion: Suspected Large Venous Invasion: Not Identified Perineural Invasion: Identified Surgical Margins: Free of tumor Polyps/Mucosa Dysplasia (away from the carcinoma): Not Identified Non-Neoplastic Bowel: Unremarkable #* Continued on next page *
+
+--- Page 2 ---
+Page 2 of  Appendix: Not identified Lymph Nodes: Numbex with metastasis: 3 Total number examined: 12. Tumor deposits in pericolorectal soft tisaue: Identified Tunor Staging (AJcc 7th Edition):. pT3 (Tumor invades through the muscularis propria into) pericolorectal tissues) Lymph Node Stage (AJcc 7th Edition):. N1b (Metastasis in 2-3 regional lymph nodes). I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. 1). The specimen is zeceived fresh,, labeled "Right colon' and consiats of a segment of terminal ileum, cecum, and ascending colon. The terminal ileum measures 5.5 cm in length and 4.5 cm in circumference at the proximal resected margin. The remaining colon measures 17 in length with a circumference ot 5.4 cm at the diatal resected margin. There is no attached appendix identified.  Focally hemorrhagic lobulated yellow tan adipose tissue spans the length of the specimen meaauring up to 1.1 cm in thicknegs. The specimen is opened to reveal a friable polypoid mass lesion measuring 6.0 cm in length and 10.0 cm in width. The mass is located in the ascending colon, 10.3 cm from the proximal margin and 5.0 cm from the distal margin. Sectioning shows the tumor invades the muscularis and abuts the underlying adipose tissue. The depth of invasion is 1.0 cm grossly. There is a 1.5 x 0.6 x 0.s cm gelatinous filled cyst cavity identified in the tunor. The remaining mucosa is tan-brown with the noxmal folds. The ileocecal valve is grossly edematous.. The attached adipose tiasue is submitted for lymph node. diasections. Representative sections of the specimen axe aubmitted for permanent sections and for Summary of sections: P proximal margin shave D- distal margin shave. -tumor C--cyst IC-. -ileocecal valve RS -representative sections. Continued on next page **
+
+--- Page 3 ---
+Page 3 of 3 LN - lymph nodes BLN - bisected lymph nodes Summary of Sections: Part 1: Sp: Terminal ileun, cecum, ascending colon; right hemicolectomy Block Sect. site FCa N m IC IN PM 8 RS F ** End of Report **
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diff --git a/output/text/0f58d5ef-5bd5-407b-a468-b2a0bdb5d59b.txt b/output/text/0f58d5ef-5bd5-407b-a468-b2a0bdb5d59b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0f4c51fd7d215cd41a0df6abba992afa411477c0
--- /dev/null
+++ b/output/text/0f58d5ef-5bd5-407b-a468-b2a0bdb5d59b.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+IcD-o-3 Ooderolipqleomo NOS 0 945of3 Tumor ID Sute c8cF Supstirtorial NOS C710 c71.2 9) 4116|13 Microscopic Description: Sections demonstrate a variably cellular glioma that diffusely infiltrates both the gray and white matter. The majority of the tumor cells demonstrate prominent perinuclear halos. They consistently have round to oval nuclei. Atypia is moderate. Cellularity is accentuated in a multinodular pattern. Neither microvascular proliferation nor necrosis are identified. A few scattered mitotic figures are seen, but these are insufficient by themselves to warrant classification as anaplastic. Scattered MiB-1 reactive cells are present throughout the tumor. However, even in the most proliferative regions, a labeling index of only 2.2% is calculated. Combined with the other histologic features, this does not warrant classification as anaplastic/grade ll. Nevertheless, the cluster of hypercellularity and degree of atypia is somewhat worrisome and close follow up is indicated. Diagnosis: UUID:34BD1967-CF9D-4B21-866A-B8100739E1C9 TCGA-HT-A615-01A-PR Redacted Left Temporal Tumor Oligodendroglioma, Grade II MI8-1 Labeling Index= 2.2%
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diff --git a/output/text/0faaf06e-5d2d-4b96-956c-40a920f87461.txt b/output/text/0faaf06e-5d2d-4b96-956c-40a920f87461.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ed240cb4d12755201b1d7da71d958724e347322f
--- /dev/null
+++ b/output/text/0faaf06e-5d2d-4b96-956c-40a920f87461.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis: Resected colon (sigma) sample with tumor-free oral and aboral resection margins, with a tubular adenoma displaying moderate dysplasia (synonym: low-grade intraepithelial neoplasia) and including a moderately differentiated adenocarcinoma with infiltration of the lamina muscularis propria. No local lymph node metastasis (G2, pT2 L0 V0 R0 pN0 0/15).
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diff --git a/output/text/0fd2c286-0399-4dee-b5af-8822f4700515.txt b/output/text/0fd2c286-0399-4dee-b5af-8822f4700515.txt
new file mode 100644
index 0000000000000000000000000000000000000000..040f945f21692977f5742028ecfd7a6a9c23e885
--- /dev/null
+++ b/output/text/0fd2c286-0399-4dee-b5af-8822f4700515.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+Sample # TCDO 3 0860D|3 duc+46S' SiLe ByBuas+NoS C 59 FINAL PATHOLOGIC DIAGNOSIS 9J 8/2/13 A. Sentinel lymph node, right axillary #1; excisional biopsy: - Five reactive lymph nodes, no evidence of tumor (0/5) (HE and CKAE1/AE3) - Lymphovascular invasion is seen in a lymph node vessel of the lymph node sinus (0.12 mm tumor cell cluster), see comment.. B. Sentinel lymph node, right axillary #2; excisional biopsy:. - One reactive lymph node, no evidence of tumor (0/1) (HE and CKAE1/AE3) C. Sentinel lymph node, right axillary #3; excisional biopsy: - One reactive lymph node, no evidence of tumor (0/1) (HE and CKAE1/AE3) D. Breast, right, additional anterior margin; excision:. - Columnar cell changes. UUID:961547D2-F235-47E9-9A6D-D286758E332E CGA-0L-A6V0-01A-PR Redacted - Blunt duct adenosis. - Apocrine metaplasia. E. Breast, right; wire-guided lumpectomy: - Invasive ductal carcinoma, SBR grade Ill, with necrosis, see parameters below. - Ductal carcinoma in situ, high nuclear grade, solid type. - Biopsy site changes. - Margins of resection are negative..
+
+--- Page 2 ---
+Breast Pathologic Parameters 1. Invasive carcinoma:. A. Gross measurement: 1.9 x 1.7 x 1.5 cm B. Composite histologic (modified SBR) grade: III - Architecture: 3 - Nuclear grade: 3 - Mitotic count: 3. C. Associated intraductal carcinoma in situ (DCIS): - Adjacent to invasive carcinoma (forming < 5% of tumor volume) 2. Intraductal carcinoma: A. Microscopic measurement: Adjacent to invasive carcinoma B. Type: Solid C. Nuclear grade: High. D. Associated features: Necrosis / Cancerization of lobules 3. Excisional biopsy margins: Free of tumor - Invasive carcinoma 3.0 mm from posterior (closest) margin - Ductal carcinoma in situ distant to all margins. - Additional margin (anterior) negative. 4. Blood vessel and lymphatic invasion: Present - Present in axillary lymph node. 5. Nipple: N/A 6. Skin: N/A 7. Skeletal muscle: N/A 8. Axillary lymph nodes: Seven sentinel lymph nodes, no evidence of tumor (0/7) 9. Special studies
+
+--- Page 3 ---
+- ER: Negative - PR: Negative - Her2/neu antigen (FIsH): Non-amplified (1.23) 10. pTNM (AJCC, 7th edition, 2010): pT1cN0(sn)MX Clinical History:e The patient is a -year-old female with breast cancer undergoing wire guided lumpectomy and sentinel node biopsy. Comment A. Present on HE slide A2 Lev 3 and CK stain. Reviewed intradepartmentally Specimens Received: A: Right sentinel node #1 B: Right sentinel node #2 C: Right sentinel node #3 D: Rt breast additional anterior margin
+
+--- Page 4 ---
+E: Right breast wire guided; lumpectomy Gross Description: The specimens are received in five containers each labeled with the patient's name and medical record number.. A. The first container is additionally identified as, 'right breast sentinel node #1'. Received fresh and placed in formalin are 2 fragments of ovoid yellow. to brown rubbery tissue. The first measures 4.0 x 2.0 x 1.3 cm and the second is 4.5 x 1.5 x 1.2 cm. A number of lymph node candidates are identified the largest of which measures 4.0 x 1.5 x 1.0 cm. The specimen is submitted as follows:. A1: 3 lymph node candidates A2: One lymph node candidate. A3-A4: One lymph node candidate bisected B. The second container is additionally identified as, 'right breast sentinel. node #2'. Received fresh and placed in formalin is an ovoid fragment of. yellow-tan fibroadipose tissue measuring 1.8 x 1.6 x 0.5 cm. A brown-tan lymph node is identified that measures 1.1 x 0.5 x 0.3 cm. It is bisected and entirely submitted in cassette B1 along with the surrounding fat.. C. The third container is additionally identified as, 'right breast sentinel node #3'. Received fresh and placed in formalin is a fragment of rubbery.
+
+--- Page 5 ---
+yellow-tanto brown tissue measuring 1.3 x 0.5 x 0.3 cm. It is entirely. submitted in cassette C1. D. The fourth container is additionally identified as, 'additional anterior. margin'. Received fresh and placed in formalin is a rectangular fragment of soft. to rubbery yellow-tan tissue measuring 2.3 x 1.7 x 0.6 cm. A double suture marks. the final anterior margin. This margin is inked blue and the remainder of the specimen is inked black. The specimen is then serially sectioned and entirely submitted in cassettes D1-D2. E. The fifth container is additionally identified as, 'right breast wire guided Iumpectomy'. Received fresh on a radiographic grid is a 45.4 gm lumpectomy specimen measuring 7 cm from medial to lateral, 5.8 cm from superior to inferior and 2.7 cm from anterior to posterior. The specimen is oriented with'a short suture designating the superior pole and a long suture'designating the lateral pole. Accompanying the specimen is an x-ray demonstrating a metallic clip Iocated in grid coordinate D3. There is a circled mass in grid positions C4, C3, and D3, and D4, centered on the clip. The wire enters the specimen in grid coordinates C3 and terminates in D4 The margins are inked as follows: anterior - black;. posterior - red;. superior - blue;. inferior - green;. medial - yellow;.
+
+--- Page 6 ---
+Iateral - violet.. The specimen is serially sectioned from medial to lateral into 8 slices. The metallic clip is identified in slice 4. The wire enters the specimen in slice 3 and terminates in slice for. There is a firm, tan, irregular, 1.9 x 1.7 x 1.5 cm lesion located in slices 3 through 4. The lesion is located 1.5 cm from the anterior (black) margin, 0.3 cm from the posterior (red) margin, 1.3 cm from the superior (blue) margin, 1.2 cm from the inferior (green) margin, 1.7 cm from the medial margin, and 4 cm from the lateral margin. The remainder of the breast  parenchyma is white-yellow and lobulated with no additional masses or lesions. Block summary: E1: medial margin, slice 1 E2: lateral margin, slice 8 E3: mass, slice 3 with red margin. E4: Surrounding margins from slice 3e E5-E6: mass, slice 4 with red margin, surrounding clip. E7: Surrounding margins from slice 4. E8: Slice 2 next to mass E9: Slice 5 next to mass E10: Section from grossly unremarkable breast parenchyma, slice 6
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diff --git a/output/text/0fd77934-c0c8-429f-a762-fdea27a2faaf.txt b/output/text/0fd77934-c0c8-429f-a762-fdea27a2faaf.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e0d632d57869b16823cb2b36d40428caf685bdd3
--- /dev/null
+++ b/output/text/0fd77934-c0c8-429f-a762-fdea27a2faaf.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Mass. kidney. right, radical nephrectomy: Chromophobe renal cell carcinoma (11.5 cm), see synoptic report Kidney: Nephrectomy, Partial or Radical Synopsis Staging according to American Joint Committee on Cancer Staging Manual -- 7th Edition MACROSCOPIC Procedure: Radical nephrectomy Specimen Laterality: Right Tumor Site: Upper pole Tumor Focality: Unifocal. Tumor Size: Greatest dimension: 11.5 cm. Additional dimensions: 9 cm x 9 cm Macroscopic Extent of Tumor: Tumor limited to kidney MICROSCOPIC Histologic Type: Chromophobe renal cell carcinoma
+
+--- Page 2 ---
+Tumor Necrosis: *Not identified Histologic Grade: Not applicable MicroscopicTumor Extension: Tumor limited to kidney EXTENT OF INVASION (Pathologic Staging,pTMN) Primary Tumor (pT): pT2b:Tumor more than 10 cm. limited to the kidney Regional Lymph Nodes (pN): pNX: Regional lymph nodes cannot be assessed Lymph Nodes:None submitted. Distant metastasis (pM):Not applicable Margins: Margins uninvolved by invasive carcinoma. Adrenal Gland: Not present Lymph-Vascular Invasion (excluding renal vein and its muscle containing segmental branches and inferior vena cava): *Not identified. Pathologic Findings in Nonneoplastic Kidney: None identified. Clinical: Right renal mass Gross:The specimen is received fresh labeled with the patient's name and additionally labeled "right kidney." The specimen consists of a kidney with attached. perinephric adipose tissue that measures 14.5 x 10.5 x 5.5 cm with attached perinephirc fat that measures 13 x 9 x 1.5 cm.The specimen weighs 613 grams.A segment of ureter is present and measures 14 cm in length and 0.4 cm in diameter. An adrenal gland is not present. The ureter is patent. The specimen is bivalved through the pelvic calyceal. system. A tumor that measures 11.5 x 9 x 9 cm is present in the upper pole of the kidney The cut surface of the tumor is solid. tan.brown and hemorrhagic.Tumor invasion into the perinephric adipose tissue and renal sinus is not identified. Invasion of the renal vein is not identified. No other lesions are noted within the renal parenchyma.The mucosa of the ureter and pelvis are unremarkable. The specimen is represented as follows: A=ureteral margin, B=vascular margin, C-D=representative sections of tumor with respect to kidney capsule, E-tumor with respect to pelvis, F-G=tumor with respect to unremarkable kidney.. H=representative sections of unremarkable kidney, I-K=representative sections of sinus,
+
+--- Page 3 ---
+915:201951AM
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diff --git a/output/text/0ff51074-dc4f-4f5e-87b9-19d5bc509b7f.txt b/output/text/0ff51074-dc4f-4f5e-87b9-19d5bc509b7f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d63ffc40f432f111e4ff0581b69c10db1b894263
--- /dev/null
+++ b/output/text/0ff51074-dc4f-4f5e-87b9-19d5bc509b7f.txt
@@ -0,0 +1,21 @@
+
+--- Page 1 ---
+IcDO3 UUID: 2D9BA65C-231F-4D7C-BD0C-442CA26E8E7C Pathology Repor TCGA-CN-A63V-01A-PR Redacted areeksne, nguansue 0e0Q N6S 8070/3 Report Type Date of Event Site:Buecolmueoee Sex C06.0 M Authored by  s/i0|13 Hosp/Group Record Status FINAL FINAL DIAGNOSIS: PART 1: BUCCAL MUCOSA, SKIN, UPPER AND LOWER LIP, LEFT, RESECTION A. INVASIVE SQUAMOUS CELL CARCINOMA, MODERATELY DIFFERENTIATED (4.0 CM), OF BUCCAL MUCOSA EXTENDING TO THE SKIN. B. NO ANGIOLYMPHATIC INVASION OR PERINEURAL INVASION.S C. MARGINS ARE FREE OF CARCINOMA (see also other parts). D. PATHOLOGIC STAGE: pT4a NO. PART 2: LIP, RIGHT LOWER, BIOPSY NO TUMOR PRESENT. PART  3: MARGIN, ADDITIONAL MUCOSA CIRCUMFERENTIAL, BIOPSY NO TUMOR PRESENT. PART 4: LIP, LEFT UPPER, BIOPSY NO TUMOR PRESENT. PART 5: ALVEOLUS, LEFT UPPER, BIOPSY NO TUMOR PRESENT. PART 6: MARGIN, LEFT POSTERIOR BUCCAL, BIOPSYS NO TUMOR PRESENT. PART 7: ALVEOLUS, LEFT LOWER, BIOPSY NO TUMOR PRESENT. PART 8: LIP, LEFT LOWER, BIOPSY NO TUMOR PRESENT. PART 9: MANDIBLE, LEFT, MARGINAL MANDIBULECTOMY NO TUMOR PRESENT, MARGINS ARE FREE OF CARCINOMA. PART 1O: LYMPH NODES, LEFT NECK, LEVEL 1, SELECTIVE NECK DISSECTION A. ELEVEN LYMPH NODES, NO TUMOR PRESENT (O/11). B. UNREMARKABLE SUBMANDIBULAR GLAND. PART 11: LYMPH NODES, LEFT NECK, LEVELS 2-4, SELECTIVE NECK DISSECTION A. THIRTY FOUR LYMPH NODES, NO TUMOR PRESENT (O/34). B. UNREMARKABLE PAROTIDTISSUE. Pathologist: * Report Electronically Signed Out **. By Pathologist: My signature is attestation that I have personally reviewed the submitted material(s) and the final diagnosis reflects that evaluation. GROSS DESCRIPTION: The specimen is received in eleven parts.. Part 1 is received fresh for intraoperative consultation labeled with the
+
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+patient' s name, initials xx, medical record number and "left buccal resection take margins." It consists of a 7.0 x 5.0 x 4.0 cm portion of left cheek with portion of upper and lower lip in total. The buccal surface of the. cheek shows a fungating, focally necrotic tumor measuring 4.0 x 3.0 cm and 3.8 cm in depth. The tumor is seen infiltrating into the skin of the cheek causing a defect measuring 1.1 x 1.0 cm. The tumor is situated within 0.1 cm of the inferior margin, 0.6 cm of the superior margin, and 0.2 cm of the. posterior margin. Gross photographs are taken.  Tissue is banked. Ink Code: Black - posterior margin. Blue superior margin. Green inferior margin. Red banked area. Section Code: 1A  tumor in relation to the superior margin 1B tumor in relation to the inferior margin 1C tumor in relation to the posterior margin 1D tumor in relation to the defect. 1E-lF tumor at the buccal surface. 1G tumor with skin.. Time in formalin:. Part 2 is received fresh for intraoperative consultation labeled with the patient' s name, initials xx, medical record number and "right lower lip biopsy." It consists of two fragments of grey tan tissue measuring 0.4 x 0.2 x 0.1 cm each which is submitted entirely in cassette labeled as 2AFs. Time in formalin: Part 3 is received fresh labeled with the patient' s name, initials xx, medical record number and "additional mucosal circumferential margin." It consists of a 12.0 x 0.8 x 0.4 cm piece of grey tan tissue submitted entirely in cassette labeled as 3A-3R. Time in formalin: Part 4 is received fresh labeled with the patient' s name, initials xx, medical record number and "left upper lip." It consists of a 2.2 x 0.4 x 0.3 piece of gray-tan tissue which is submitted entirely in cassette. labeled as 4AFS. Time in formalin: Part 5 is received fresh for intraoperative consultation labeled with the patient' s name, initials xx, medical record number and "left upper alveolus." It consists of a 2.8 x 0.3 x 0.2 cm piece of gray-tan tissue which is submitted entirely in cassette labeled as 5AFs.
+
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+Time in formalin: Part 6 is received fresh labeled with the patient' s name, initials xx, medical record number and "left posterior buccal margin." It consists of two fragments of tissue measuring 1.2 x 0.5 x 0.3 cm and 1.2 x 0.7 x 0.5 cm, which is submitted entirely in cassette labeled 6AFs. Time in formalin: Part 7 is received fresh labeled with the patient' s name, initials xx, medical record number and "left lower alveolus." It consists of a 0.8 x 0.6 x 0.2 piece of gray-white tissue which is submitted entirely in cassette labeled as 7aFs. Time in formalin: Part 8 is received fresh for intraoperative consultation labeled with the patient' s name, initials Xx, medical record number and "left lower lip." It consists of a 2.5 x 0.3 x 0.2 cm piece of tissue which is submitted entirely in cassette labeled as 8Ars. Time in formalin: Part 9 is received fresh labeled with the patient' s name, initials xx, medical record number and "left marginal mandibulectomy." It consists of a 0.6 x 0.9 x 1.1 cm portion of mandible with four defects. Ink Code: Black deep margin. Section Code: 9A one margin 9B other margin 9C representative section of the mid portion. Time in formalin: Part 10 is received fresh labeled with the patient' s name, initials xx, medical record number and "left neck level 1." It consists of a 6.0 x 5.0 x 2.0 cm potion of fibroadipose tissue. On dissection a submandibular gland measuring 5.0 x 3.0 x 2.0 cm is noted. Section Code: 10A one lymph node entirely submitted 10B  submandibular gland 1C-1D representative sections of the fat 10E three possible lymph nodes 10F one lymph node 10G four possible lymph nodes 1OH fat. Time in formalin: Part 11 is received fresh labeled with the patient' s name, initials xx, medical record number and "left neck level 2-4." It consists of an unoriented portion of fibroadipose tissue with lymph nodes measuring 12.0 x 8.0 x 2.0 cm.
+
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+Section Code: Level 2: 11A one lymph node 11B four possible lymph nodes 11C four possible lymph nodes 11D fat. Level 3: 11E six possible lymph nodes 11F four possible lymph nodes 11G four possible lymph nodes. Level 4: 11H two possible lymph nodes. 111 five possible lymph nodes. 11J six possible lymph nodes. Time in formalin: INTRAOPERATIVE CONSULTATION: PART 1AGD: LEFT BUCCAL RESECTION (gross consultation) A. SATISFACTORY FOR ANCILLARY STUDIES. B. GrOSS OnLy. C. FROM CENTER OF LESION.  CARCINOMA IS WITHIN O.1 CM OF THE INFERIOR MARGIN AND 0.6 CM FROM THE SUPERIOR MARGIN AND O.2 CM FROM THE POSTERIOR MARGIN. ALL CUTANEOUS MARGINS ARE MORE THAN O.5 CM OF CARCINOMA PART 2AFS: RIGHT LOWER LIP, BIOPSY (frozen section) A. SATISFACTORY FOR ANCILLARY STUDIES. B. BENIGN. C. NO TUMOR; GRANULATION TISSUE PART 4AFS: LEFT UPPER LIP, MARGIN, EXCISION (frozen seCtion) A. SATISFACTORY FOR ANCILLARY STUDIES. B. BENIGN. C. NO TUMOR PRESENT ( Md) . PART 5AFS: LEFT UPPER ALVEOLUS, SHAVE MARGIN, EXCISION (frOZen SeCtion) A. SATISEACTORY FOR ANCILLARY STUDIES. B. BENIGN. C. NO TUMOR PRESENT MD) . PART 6AFS: LEFT POSTERIOR BUCCAL SHAVE MARGIN (frOZen seCtion) A. SUFFICIENT FOR ANCILLARY STUDIES. B. BENIGN. C. FOCAL MILD DYSPLASIA PART 7AFS: LEFT LOWER ALVEOLUS, BIOPSY (frozen seCtion) A. SUFFICIENT FOR ANCILLARY STUDIES. B. BENIGN.
+
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+C. NO TUMOR PRESENT Md). PART 8AFS: LEFT LOWER LIP, BIOPSY (frozen section) A. SUFFICIENT FOR ANCILLARY STUDIES. B. BEnign. C. NO TUMOR PRESENT md). MICROSCOPIC: Microscopic examination substantiates the above diagnosis. The following statement applies to all immunohistochemistry, Insitu Hybridization Assays (Ish & Fish), Molecular Anatomic Pathology, and Immunofluorescent Testing: The testing was developed and its performance characteristics determined by the Department of Pathology, as required by the CLIA specific use by the U.s. Food and Drug Administration, but the FdA has determined such approval is not necessary for clinical use. fixation  Tissue ranges from a minimum of 2 to a maximum of 84 hours. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 ("cLiA") as qualified to perform high-complexity clinical testing. Pursuant to the requirements of cLiA, AsR's used in this laboratory have been established and verified for accuracy and precision. Additional information about this type of test is available upon request. CASE SYNOPSIS: SYNOPTIC DATA - PRIMARY UPPER AERODIGESTIVE TRACT AND SALIVARY GLAND TUMORS SPECIMEN TYPE: Resection: left buccal resection TUMOR SITE: Other: oral cavity, cheek TUMOR SIZE: Greatest dimension: 4 cm HISTOLOGIC TYPE: Squamous cell carcinoma, conventional HISTOLOGIC GRADE: G2 PRIMARY TUMOR (pT) :) pT4a REGIONAL LYMPH NODES (pN): pNO Number of regional lymph nodes examined: 45 Number of regional lymph nodes involved: 0 DISTANT METASTASIS (pM) :) pMX MARGINS: Margins uninvolved by tumor VENOUS/LYMPHATIC (LARGE/SMALL VESSEL) INVASION (V/L) : Absent PERINEURAL INVASION: Absent PATIENT HISTORY: CHIEF COMPLAINT/ PRE-OP/ POST-OP DIAGNOSIS: Invasive squamOuS cell carcinoma. PROcEDuRE: Excision buccal lesion.
+
+--- Page 6 ---
+SPECIFIC CLINICAL QUESTION: Not answered. OuTsiDe TIssuE DiagnosiS: Not answered. PRIOR MALIGNANCY: Not anSwered. CHEMORADIATION THERAPY: Not anSwered. ORGAN TRANSPLANT: Not anSwered. Immunosuppression: Not answered. OtheR DiseAses: Not answered. HISTO TISSUE SUMMARY/SLIDES REVIEWED: Part 1: left buccal resection Stain/ Block H&E x 1 A H&E x 1 B H&E x 1 c H&E x 1 D H&E 1 [] + H&E 1 F x H&E x 1 G Part 2: Lip biopsy, right lower Stain Block H&E x 1 AFS Part 3: Additional mucosal cirfcumferential margin Block Stain/ H&E x 1 A H&E x 1 B Part 4: Lip, left upper. Stain/ Block H&E x 1 AFS Part 5: Left upper alveolus Stain, Block H&E x 1 AFS Part 6: Left posterior buccal margin Stain/ Block H&E x 1 AFS Part 7: Left Lower alveolus Block Stain/ H&E x 1 AFS Part 8: Lip. left lower Stain/ Block H&E x 1 AFS Part 9: left marginal mandibulectomy. Stain, Block H&E x 1 ADR H&E x 1 BDR H&E x 1 CDR Part 10: Neck Dissection, left level 1 Stain, Block
+
+--- Page 7 ---
+H&E x 1 A H&E x B H&E x H&E X D H&E x E H&E x F H&E x G H&E x 1 H Part. 11: Neck Dissection, left levels 2-4 Stain/ Block H&E x 1 A H&E x B H&E c + H&E 4 D H&E X E H&E 1 F H&E  X G H&E x H&E x I H&E x J H&E x K H&E x L H&E x 1 M H&E x 1 N lw 4fa113
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diff --git a/output/text/0ff93289-a58f-42e2-9add-187c139df974.txt b/output/text/0ff93289-a58f-42e2-9add-187c139df974.txt
new file mode 100644
index 0000000000000000000000000000000000000000..68e2e56dbc67f98ceb3fef07d665909c58fc0be1
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+
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+UUID:643C84D1-C247-4CA6-84C3-38ED99E886F6 TCGA-CC-A7IH-01A-PR Redacted IRB APPROVED Form Revised Fax: Clinical Case Report IZD 0 -3 8I7013 Uos Sute onie: AQQD Ai0(10113 Informed Consent I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institntion. Lunical Intormation GENERAL INFORMATION Date of Birth (mm/dd/yyyy) Helght Marital Status Race Temperature Gender Weight Blood Pressure Heart Rate Male  Female 2 HISTORY OF PRESENT ILLNESS Symptoms: WeiqRt Wcs j yellow Skin Clinical Findings: Performance Scale (Karnofsky Score):  100 Asymptomatic  80-90 Symptomatic but Fully Ambulatory  60-70 Symptomatic, in bed less than 50% of day 40-50 Symptomatic, in bed more than 50% of day, but not bed ridden  20-30 Bed Ridden CURRENT MEDICATIONS Drug Dose Route Frequency Date (mm/dd/yyyy) To To / 1 To 1 To 1 / To
+
+--- Page 2 ---
+PAST MEDICAL HISTORY Dlagnosis/Disease/Disorder/Injury Diagnosis Date Treatment Status OB/GYN HISTORY Menopausal Status Date of First Menses # of Pregnancies   Pre-menopausal  Peri-Menopausal Date of Last Menses # of Live Births.  Post-menopausal Birth Control:  Condom  Oral Contraceptive IUD  Hormone Replacement Therapy:  Other: SOCIAL HISTORY Occupation: Environmental Hazards: Smoking History Current Status TYPE Packs/day Duration When Quit YES DANO (yrs) (yr). Alcohol Consumption Current Status TYPE Drinks/day Duration When Quit SAYES  nO 2dnnlcdas 30 (yrs) bmmmt cs(o (ys) Drug Use C Current Status TYPE Frequency Duration When Quit  YES SONO (yrs) y FAMILY MEDICAL HISTORY Relative Diagnosis Age of Dlagnosis LAB DATA Test Result Date Test Result Date HIV Negative  Positive: CEA  Negative  Positive: Hep B  Positive: Negative CA 15-3 Negative   Positive: Hep C  Positive: CA 19-9  Negative  Positive: Negative AFP  Negative  Positive: PSA  Negative  Positive: Other: Other: .Negative  Positive:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+DIAGNOSTIC STUDIES Study Results Date Ultrasound X-Ray CT 4 Endoscopy MRI Biopsy CLINICAL DIAGNOSIS  Preoperative Clinical Diagnosis Liyek Mteee Location of Suspected Involved Lymph Nodes Location of Suspected Distant Metastasis Clinical Staging  Date of Diagnosis I3 No Md Stage: HA Treatment Information SURGICAL TREATMENT Procedure Date of Procedure Qesecticn s. the. Lost Primary Tumor Organ Detailed Location Size Jiter. LecreR eLt LiUeR 8x x4 cm . Extension of Tumor Lymph Nodes Description Location of Lymph Nodes. # of Lymph Nodes Palpable, Non-Dissected Lymph Nodes. Dissected Lymph Nodes Distant Metastasis Organ Detailed Location Size Surgical Staging T 3 NO mo Stage: NEOADJUVENT THERAPY (Chemo, Radiation, Immuno, Hormonal, or Molecular) Drug/Treatment Dose Route Frequency Date (mm/dd/yyyy) To To 1 1 To 1 / To 1 To / 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by: Date: me: Preserved by: -- Date: Time: SPECIMEN TYPE (# of samples provided) Frozen Paraffin Block.  Blood/Serum/Plasma  Slide Diseased Normal Diseased  Normal Diseased Normal Diseased Normal 4 2 + 2 + 2 Time to LN2 Time to Formalin Time to LN2 min min min PATHOLOGICAL DESCRIPTION Primary Tumor Organ Size Extension of Tumor. Distance to NAT Lieer Teeneu? 8xx cm 6 cm Lymph Nodes Location # Examined # Metastasized Distant Metastasis Organ Detailed Locatlon Size Pathological Staging pT 3 No m o Stage: A Notes:
+
+--- Page 5 ---
+IRB APPROVED Form Revised 'el: Fax: Consolidated Pathology Diagnosis Cell Distribution + Structural Pattern + Diffuse Streaming  Mosaic  Storiform Necrosis Fibrosis Lymphocytic Infiltration  Palisading Vascular Invasion Cystic Degeneration  Clusterized Bleeding Alveolar Formation  Myxoid Change Indlan File  Psammoma/Calcification Squamous Adenomatous + Sarcomatous +-  Lymphomatous Squamoid Cell Glandular cell  Round Cell  Large Cell  Spindle Cell Cell Stratification Fibroblast Small Cell Keratin Secretion Osteoblast RS Cell/RS Like  Desmosome Intracyt. Vacuole Lipoblast  Inflam. Cell Peart Gland formation Myoblast  Plasma Cell Cellular Differentiation: Well  Moderate  Poor Nuclear Atypia: 0 II III Aniso Nucleosis Hyperchromatism Nucleolar Prominent. Multinucleated Giant Cell Mitotic Activity Nuclear Grade: D qoy brqt%,b3qd7 149c Final Pathology Report Histological Diagnosis: ylet tnisi/tz(ah Cekc r/nrsGrade:_1 h s/3y3 Comments: Date INTEGRATED REPORT OF FINDINGS BY COLLABORATORS AND ATHOLOGISTS -- fOR ReSeARCh USe OnLy
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diff --git a/output/text/0ffd321f-1593-4721-9b99-6db0cc1c8b34.txt b/output/text/0ffd321f-1593-4721-9b99-6db0cc1c8b34.txt
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index 0000000000000000000000000000000000000000..51df9b35bdd7534ac0144957dc3c9c5d85ac2301
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+Clinical Diagnosis & History: Invasive duct carcinoma left breast 5:0 and severe ADH left breast 11:00 (on core biopsy); for left total mastectomy, SLNB, possible left ALND and immediate reconstruction. Specimens Submitted: 1: SENTINEL NODE #1, LEVEL ONE LEFT AXILLA, EXCISION:  UUID:4022B2EB-04C3-43F6-902C-1A47D80EF6EE TCGA-AO-A037-01A-PR 'Redacted 2: SENTINEL NODE #2, LEVEL ONE LEFT AXILLA, EXCISION 3: NON-SENTINEL NODE, LEFT AXILLA, EXCISION 4: BREAST, LEFT, SIMPLE MASTECTOMY DIAGNOSIS: SUMMARY OF FINDINGS IN THIS CASE: Invasive ductal carcinoma present as two foci spaning 28 mm and 2 mm and is 3.6 cm from the closest inked margin. The nipple dermis is involved by invasive ductal carcinoma. Mucinous carcinoma spans 2.5 mm and does not involve the inked margin.. All foci of invasive carcinoma (ductal and mucinous) are 3R positive, HER2 negative. DCIS is present and is 3.6 cm from the closest inked margin. Sentinel lymph nodes: 2/3.. Non-sentinel lymph nodes: 1/1. Total lymph nodes: 3/4. Type of metastasis: macrometastasis (6 mm) to an intramammary lymph node 1.  SENTINEL NODE #1, LEVEL ONE LEFT AXILLA, EXCISION:: Sentinel Lymph Node Status:. Number of Sentinel Lymph Nodes Bxamined: 1 Number of Sentinel Lymph Nodes with carcinoma: 1 Size of Largest Metastatic Focus: >- 0.2 mm to -< 2 mm (micrometastasis) The metastatic focus spans 0.4 mm Level of Detection: Initial H&e stained section Extracapsular Extension: Not present. 2 SENTINEL NODE #2, LEVEL ONE LEFT AXILLA, EXCISION: ** Continued on next page ** 1cs-0-3 carciorx, mfiHtnaHtj cuct"arL mnu ci`Ncus 8573|3 Site: brst,Nos C50.9 h 10/22f ISQUALIFIED
+
+--- Page 2 ---
+Sentinel Lymph Node Status:. Page Number of Sentinel Lymph Nodes Examined: 1 Number of Sentinel Lymph Nodes with carcinoma: 1 Size of Largest Metastatic Focus: > 2 m The metastatic focus spans 3 mmm Level of Detection: Initial H&e stained section Extracapsular Extension: Present, measuring < 2mm in largest diameter. Non-sentinel node, left axilla, excision:  One benign lymph node (0/1). BREAST, LEFT, SIMPLE MASTECTOMY: Invasive Carcinoma: Ductal, NOs type Focal mucinous carcinoma (see note) Histologic Grade: II/ill: Minimal or no tubule formation (< 10% of tumor) Nuclear Grade: III/ill (marked variation in size and shape) Tumor Size: Two foci (size specified below) the invasive ductal carcinoma spans 28 mm and 2 mm. Ductal carcinoma in situ (cis): Present DCIs, Architecture: Solid  Papillary DCIs Nuclear Grade: High Necrosis in DcIS:  Minimal Extensive intraductal component (>25% of tumor mass): Not Identified Lobular Neoplasia: Lobular carcinoma in situ (Lcis), classical type Location of Invasive Carcinoma: Upper inner quadrant (UIQ) Lower inner quadrant LIQ Location of DcIs: Upper inner quadrant (UIQ) Lower inner quadrant (LIQ) Nipple Involvement: Invasive carcinoma involves the nipple stroma Skin: Tumor emboli are present in dermal lymphatic channels The examined skin margins are uninvolved by carcinoma Calcification: In benign breast tissue. In invasive carcinoma Lymphovascular Invasion: *+ Continued on next page **
+
+--- Page 3 ---
+Present Page Surgical Margins: Invasive carcinoma is 36 mm from the closest margin. DCIs is 36 mm from the closest margin Benign Breast Tissue:. Atypical ductal hyperplasia (ADH) Fibrocystic changes, including apocrine metaplasia, cyst formation and stromal fibrosis  Biopsy site changes Colummar cell changes Lymph Nodes: LN - Number of lymph nodes with metastatic carcinoma: 1 Number of lymph nodes examined: 1 The mass identified in the uoq at 1:00 is an intramammary lymph node, almost enrtirely replaced by metastaic carcinoma. The metastaic carcinoma measures 0.6 cm and is negative for wTl. Results of immunostains for calponin and p63 support the diagnosis.. A 2.5 mm focus of invasive mucinous carcinoma is also identified, with nuclear grade II/iII. Immunohistochemical stains were performed on formalin-fixed tissue with the following results for INVASIVE DUCTAL CARCINOMA (bloCk 4-5) :) ESTROGEN RECEPTOR (6F11, 90% nuclear staining with strong intensity PROGESTERONE RECEPTOR (1B2; HER2 (4B5, negative (no nuclear staining) Negative (0 / 1+) The invasive ductal carcinoma is negative for wr1.. The smaller focus of invasive ductal carcinoma has similar inmunoprofile. Positive membranous immunoreactivity for E-cadherin supports ductal. differentiation. MUCINOUS CARCINOMA (bloCk 4-19) : ESTROGEN RECEPTORS 95% nuclear staining with strong intensity PROGESTERONE RECEPTOR ( 95% nuclear staining with strong intensity HER2 ( Negative (0) The mucinous carcinoma is positive for wr1.. Comment: Controls are satisfactory. an FDA-approved rabbit monoclonal primary antibody (clone 4B5) directed PATHWAY anti-HER-2/neu is against the internal domain of the c-erbb-2 oncoprotein (Her2) for inmunohistochemical detection of HeR2 protein overexpression in breast cancer tissue routinely processed for histologic evaluation. The HeR2 test results are reported in accordance with the Asco/cAp guideline recommendations for HER2 testing in breast cancer (J clin Oncol 2007;) 25(1) :118-145). The ER and PR rabbit monoclonal antibodies are also FDA approved. ** Continued on next page
+
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+Page 4 of 6 I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. *** Report Blectronically Signed Out *** Gross Description: 1) The specimen is received fresh for frozen section consultation, labeled "sentinel node #1, level one, left axilla" and consists of a single node measuring 1 cm. Bisected and entirely submitted for frozen section. Sumary of sections: FSC -- frozen section control. 2) The specimen is received fresh for frozen section consultation, labeled "sentinel node #2, level one, left axilla" and consists of a single node measuring 2.0 cm. Bisected and entirely submitted for frozen section. Summary of sections:. Fsc -- frozen section control 3) The specimen is received fresh for frozen section consultation, labeled "non-sentinel node left axilla" and consists of a single fatty node measuring 0.7 cm. Bisected and entirely submitted for frozen section. Summary of sections: FSC ! -- frozen section control. 4.) The specimen is received fresh labeled, "Left total mastectomy, suture marks axillary aspect" and consists of a previously incised, 24.1'x 19.5 x 4.6 cm breast with a partially overlying, 11.7 x 3.5 x 0.1 cm skin ellipse. Situated centrally on the skin surface is a 1.2 x 1.2 x 0.1 cm, crusty, partially inverted, diffusely indurated, nipple with smooth, pink-white suspicious cut surfaces surrounded by a 4.7 x 3.4 cm areola. tan-white skin is free of any gross abnormalities. The wrinkled,. 7.2 x 4.6 x 0.5 cm axillary aspect. A suture demarcates the. inked black, the anterior blue and the axillary aspect is inked yellow. The The posterior surface of the breast is specimen is serially sectioned to reveal a 2.8 x 2.4 x 2.1 cm, firm, lobular and outer quadrants, from 5 o'clock to 7 o'clock, underlying the nipple, 0.5 cm from the nipple base and 3.6 cm from the deep margin, (designated Mass #1). nipple.  Also, 5.9 cm superior and 1.5 cm medial to Mass #1, is a 2.5 x 2.2 ** Continued on next page **.
+
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+x 1.3 cm, biopsy site partially surrounded by moderately dense, focally; upper outer quadrant, at 1 o'clock, 5.1 cm the nipple and 3.2 cm from the deep margin, (designated Biopsy site #1). biopsy site #1 is a twist-clip situated within a 2.6 x 1.6 x 1.4 cm.  In addition, partially abutting weli-healed biopsy site with a peripherally attached 0.9 x 0.9 x 0.7 cm, ovoid, firm, smooth to nodular bordered, white to indigo blue ink-tinged mass, located within the upper outer quadrant, at 2 o'clock, 5.5 cm from the nipple and 4.2 cm the deep margin (designated Biopsy site #2 and Mass #2). The remaining breast parenchyma consists of lobules of yellow adipose separated by bands of mild to moderately dense, focally nodular and cystic, white fibrous tissue. Sectioning of the axillary aspect reveals no grosslv identifiable lymph nodes. TPS is submitted of Mass #1, per protocol following microscopic review of the specimen. Summary of sections: N - nipple NB - nipple base D - deep margin M1 Mass #1 BX1  Biopsy site #1 BX12 Biopsy sites #1 a #2 BX2 -- Biopsy site #2 M2BX2  Mass #2 with Biopsy site #2 M2 Mass #2 UIQ - upper inner quadrant LIQ - J lower  inner quadrant UoQ - upper outer quadrant LOQ - lower outer quadrant AD12 skin additional sections, 12 o'clock AD3 skin additional sections, 3 o'clock AD6  skin additional sections, 6 o'clock AD9 skin additional sections. 9 o'clock Summary of Sections: Part 1:  SENTINEL NODE #1. LEVEL ONE LEFT AXILLA, EXCISION: Block Sect. site pCs FSC 1 Part 2: SENTINEL NODE #2, LEVEL ONE LEFT AXILLA, EXCISION Block Sect.  Site pCs 1 FSC 1 Part 3:  NON-SENTINEL NODE, LEFT AXILLA, EXCISION Block Sect. Site PCs 1 Fsc 1 ** Continued on next page **
+
+--- Page 6 ---
+Part 4: BREAST, LEFT, SIMPLE MASTECTOMY Block Sect. Site PCs 1 AD12 1 AD3 1 AD6 1 AD9 1 BX1 5 BX12 1 BX2 1 D 1 LIQ 22 1 LOQ 6 M1 6 1 M2 H21 M2BX2 N NB 5 1 1 UIQ UOQ 2 Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. FROzeN skcTION DIAGNOsIs: SP: Sentinel node #1 level 1 left axilla (fs): Benign PERMANENT DIAGNOSIS: SEE FINAL DIAGNOSIS 2. FROzRN spamtoN DIAGNOsIs: SP: Sentinel node #2 level 1 left axilla (fs):  Benign  PERMANENT DIAGNOSIS: SEE FINAL DIAGNOSIS 3. FROzeN secTIOn DIAgNosIs: SP: Non-sentinel node left axilla (fs): Benign PERMANENT DIAGNOSIS: SAME ** End of Report
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+
+--- Page 1 ---
+AMENDED/CORRECTED REPORT: Amended date: Reason: Spelling / Typographical Edit. This report being amended is to make correction to a typographical error on diagnostic line 'C' of Part 2, *THE GREATEST DIMENSION OF THE NEOPLASM IS 3.0 cm", which is corrected to read as, "THE GREATEST DIMENSION OF THE NEOPLAsM is 7.5 cm", in the Final Diagnosis field. While it was correctly stated in the Case Synopsis field. This Amended/Corrected Report reflects NO change to the previously rendered diagnoses. The attending Physician, has been notified of the error by e-mail on Original sign-out date: This Amended Report supersedes all prlor reports under this accession number and should be the only one used for patient nagement. All reports, both original and amended, are maintained in electronic archives and are available upon request. FINAL DIAGNOSIS: PART 1: ADIPOSE TISSUE, PERINEPHRIC, EXCISION A.  UNREMARKABLE FIBROADIPOSE TISSUE. B. NO EVIDENCE OF MALIGNANCY. PaRt 2: KIDNey, LEft, PaRTial NEphrECTOMY  Papillary renal Cell carcinoma, type I. A. B.  FUHRMAN NUCLEAR GRADE IS 2. C. THE GREATESt DIAMETER OF THE NEOPLASM IS 7.5 cm. D.  THE NEOPLASM IS CONFINED WITHIN THE RENAL CAPSULE. E. THE RENAL. VEIN IS NOT INCLUDED IN THIS SPECIMEN AND HAS NOT BEEN EVALUATED. F. NO EVIDENCE OF ANGIOLYMPHATIC INVASION IS IDENTIFIED. G. ALL SURGICAL MARGINS ARE FREE OF THE NEOPLASM. H. THE NON-NEOPLASTIC KIDNEY IS UNREMARKABLE. TNM STAGE: pT2a NX MX.  PArt 3: KIdney, RIght, TUmor BaSE, BiOpSy A.  CAUTERIZED UNREMARKABLE RENAL PARENCHYMA AND ADIPOSE TISSUE B.  NO EVIDENCE OF MALIGNANCY. CASE SYNOPSIS: SYNOPTIC DATA - PRIMARY KIDNEY TUMORS SPECIMEN TYPE: Partial nephrectomy LATERALITY: Left TUMOR SITE: Not specified FOCALITY: Unifocal TUMOR SIZE: Greatest dimension: 7.5 cm MACROSCOPIC EXTENT OF TUMOR: Tumor limited to kidney HISTOLOGIC TYPE: Papillary renal cell carcinoma HISTOLOGIC GRADE (Fuhrman Nuclear Grade): G2 PATHOLOGIC STAGING (pTNM): pT2a pNX Number of regional lymph nodes examined: 0 pMX MARGINS: Margins uninvolved by invasive carcinoma ADRENAL GLAND: Not present LYMPH-VASCULAR INVASION (LVI): Absent/not identified PATIENT HISTORY:  No signlficant history entered Preop Diagnosis: left renal mass Postop Diagnosis: left renal mass Surgical Procedure: NEPHRECTOMY COMPLETE  Reason previous hospitalization/sun anterior cervical discectomy Date of Surgery/Hospitalization =  Reason previous hospitalization/surgery = lumbar fusion Date of Surgery/Hdspitalization= Reason previous hospitalization/surgery = bilateral feet and removal of hardware Date of Surgery/Hospltalization   Reason previous hospitalization/surgery  = left rotator cuff repair Date of Surgery/Hospitalization - Reason previous hospitalization/surgery = hyst Cardiovascular medical history = Atrial fibrillation, Heart murmur, Hypertension Musculoskeletal medical history = Arthritls, Other: arthntis in neck Endocrine/metabolic medicat history = Diabetes Type II Gastrointestinal medical history = GERD Eye/ear medical history = Other: glasses Genitourinary/renal medical history = Other: mass It kidney  Skin condition medical history = Piercing  Reaction to anesthesia = No Reaction to biood/blood products? = Never received blood/blood products
\ No newline at end of file
diff --git a/output/text/1042725e-06a8-465b-812a-325cb2d9db5d.txt b/output/text/1042725e-06a8-465b-812a-325cb2d9db5d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f1d69973ef0f833e1cdbbcfad715fc7cd67e9fbd
--- /dev/null
+++ b/output/text/1042725e-06a8-465b-812a-325cb2d9db5d.txt
@@ -0,0 +1,24 @@
+
+--- Page 1 ---
+14/21f UUID:DD89D265-9E20-49C2-93BD-666BE7D5E41I TCGA-A1-A0SD-01A-PR Redacted Ics-0 -3 c arciioma, rifiIfraHng 0luct N0s 85ot/3 Site : brst Nos c5o.9 lw 1c/21/ Final Pathologic Diagnosis:. A. Sentinel lymph node, left axilla, biopsy: No tumor (0/1). B. Sentinal lymph node, left axilla, biopsy: No tumor (O/1). C. Left breast, needle localized partial mastectomy: 1. Invasive ductal carcinoma, 4 cm, grade 2, present at anterior margin; see comment. 2. Ductal carcinoma in situ, low and intermediate nuclear grade with necrosis, negative margins; see comment. 3. Calcifications associated with DCiS and benign epithelium. 4. Proliferative fibrocystic changes (usual ductal hyperplasia, apocrine metaplasia, cyst formation). 5. Prior biopsy site changes. D. Left axilla, excision: No tumor. E. Lymph node, left axilla, biopsy: No tumor (O/1). Note: Breast Tumor Synoptic Comment - Laterality: Left breast. - Invasive tumor type: Ductal.. - Invasive tumor size: 4 cm maximum diameter (eight consecutive specimen slices involved, each 0.5 cm thick). - Invasive tumor grade (modified Bloom-Richardson): Nuclear grade: 3, 3 points. Mitotic count: 6 mitotic figures/10 HPF, 1 point. Page I of 8
+
+--- Page 2 ---
+Surgical Pathology -. Working Draft Tubule/papilla formation: 10-75%, 2 points.. Total points and SBR grade = 6 points, grade 2. - Lymphatic-vascular invasion: Not identified.. - Perineural invasion: Not identified. - Resection margins for invasive tumor:. - Deep margin: Negative; closest distance of tumor 0.2cm (slide C6). - Medial margin: Negative; closest distance of tumor 1.1 cm (gross).. - Lateral margin: Negative; closest distance of tumor 1.3 cm (gross). - Anterior/superior margin: Positive (slides C13 and C17). - Anterior/inferior margin: Negative; closest distance of tumor 0.4 cm (slides C3 and C14). - Ductal carcinoma in situ (Dcis) type: Cribriform. - Ductal carcinoma in situ size: Foci span throughout the invasive component. - Ductal carcinoma in situ nuclear grade: Low-to-intermediate.. - Necrosis in ductal carcinoma in situ: Present. - Microcalcifications: Present in association with DciS and benign ducts. - Resection margins for ductal carcinoma in situ: - Deep margin: Negative; closest distance of tumor 0.2 cm (slide C2).. - Medial margin: Negative; closest distance of tumor, <0.2 cm; (slide C1). - Lateral margin: Negative; closest distance of tumor greater than 1 cm (gross). - Anterior/superior margin: Negative; closest distance of tumor O.5 cm (slide C2) - Anterior/inferior margin: Negative; closest distance of tumor greater than 1 cm (gross). - Lymph node status: Negative. - Number of positive lymph nodes: 0 - Total number sampled: 3. - AJCC/UICC stage: pT2NOMX. Intraoperative Consult Diagnosis FS1 (A) Sentinel lymph node cluster, left axilla, biopsy: No tumor seen. (Dr. FS2 (B) Left axilla, sentinel lymph node #2, biopsy: No tumor seen. (Dr. Clinical History The patient is a. year-old woman with a history of biopsy-proven low-grade invasive and in situ ductal carcinoma( ') who undergoes left breast needle-localized lumpectomy and sentinel lymph node sampling. Gross Description The specimen is received fresh in five parts each labeled with the patient's name and unit number. It consists of one soft, pink-yellow, irregular, Part A is additionally labeled ' glistening, unoriented, fibroadipose tissue fragment that is 2.8 x 1.8 x 0.9 cm. The specimen is entirely submitted for frozen section. The frozen remnant is entirely submitted in cassette A1. : It consists of one soft, pink-yellow. Part B is additionally labeled irregular, glistening, unoriented, fibroadipose tissue fragment that is 3 x 2.5 x 0.7 cm.A single large lymph node candidate is identified, bisected, and entirely submitted for intraoperative consuitation with the remnant submitted in cassette B1. The remaining adipose tissue is submitted in cassette B2. " It consists of a lumpectomy specimen measuring 5.4 Part C is additionally labeled ' cm from superior to inferior, 6.4 cm from medial to lateral and 2.6 cm from anterior to posterior. The specimen has been oriented with a long black surgical indicating the lateral position and a short black surgical suture indicating the superior position. The specimen is coronally sectioned from medial to lateral into 13 slices to reveal diffusely white-yellow breast parenchyma with an apparent biopsy site cavity extending from slices 7 through 10 and measuring 2.6 cm from superior to inferior, 4.4 cm from medial to lateral and 2.4 cm from anterior to posterior. The specimen is inked as follows for microscopic evaluation of surgical margins: Anterior-superior black-yellow, anterior-inferior green and posterior black. Representative sections are submitted as follows: Cassette C1: Slice 1 (medial margin), perpendicular. Cassette C2: Slice 3. Slice 4, inferior.. Cassette C3:  Page 2 of 8
+
+--- Page 3 ---
+Surgical Pathology -- Working Draft Cassette C4: Slice 5, inferior. Cassette C5: Slice 6, superior. Cassette C6: Slice 6, mid. Cassette C7: Slice 6, inferior. Cassette C8: Slice 7, superior. Cassette C9: Slice 7, inferior. Cassette C1O: Slice 8, superior. Cassette C11: Slice 8, mid. Cassette C12: Slice 8, inferior. Cassette C13: Slice 9, superior. Cassette C14: Slice 9, mid. Cassette C15: Slice 9, inferior. Cassette C16: Slice 10, superior. Cassette C17: Slice 10, mid. Cassette C18: Slice 10, inferior. Cassette C19: Slice 11. Cassette C20: Slice 13 (lateral margin), perpendicular. Slices 1, 6, 7, 8, 9, 10 and 13 are entirely submitted. : It consists of two unoriented fragments of Part D is additionally labeled ". yellow-tan, fibroadipose tissue measuring 3.0 x 2.5 x 0.5 cm. The specimen is entirely submitted in cassette D1. It consists of a single unoriented Part E is additionally labeled " fragment of tan-yellow, soft tissue measuring 0.6 x 0.5 x 0.3 cm. A single candidate lymph node is identified, measuring O.6 cm in greatest dimension. The specimen is entirely submitted in cassette E1.  MD/Pathologist /Pathology Resident Signed: Fee Codes: Other Specimens Specimen Class: Status: Signed Out Accessioned Signed Out: Specimen(s) Received: Lip, upper left Final Diagnosis Lip, upper left: Mucous retention cyst Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Left breast re-excision (fresh) Final Diagnosis Left breast, excisiona! biopsy: 1. No residual tumor. 2. Prior surgical site changes. 3. Microcalcifications in benign ducts and lobules.  mD  mD Page 3 of 8
+
+--- Page 4 ---
+Surgical Pathology  Working Draft Specimen Class: Status: Signed Out Aecessioned: Signed Out: Specimen(s) Received: Vaginal/Cervical/Endocervical, Thin Prep Imaged Final Diagnosis Vaginal/Cervical/Endocervical, Thin Prep Imaged NEGATIVE FOR INTRAEPITHELIAL LESION OR MALIGNANCY Other Interpretations/Results: SHIFT IN FLORA SUGGESTIVE OF BACTERIAL VAGINOSIS. SPECIMEN ADEQUACY: Satisfactory for evaluation. Transformation zone components are present _Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Left breast core biopsy at. ,N+4 Final Diagnosis Left breast, , core biopsy: 1. Invasive ductal carcinoma, SBR grade 1; see comment. 2. Ductal carcinoma in situ, intermediate grade with comedonecrosis. 3. Calcifications within ductal carcinoma in situ. Procedure/Addenda for AdDEndum. Date of Addendum.:. Addendum Comment An immunohistochemical test for estrogen and progesterone receptors as well as for HER2 was performed on block Al. The test for estrogen receptors is positive. There is strong nuclear staining in >90% of tumor cells.. The test for progesterone receptors is positive. There is strong nuclear staining in >90% of tumor cells.. Result of HER2/neu test: This carcinoma is negative for HER2/neu oncoprotein over-expression. An immunohistochemical assay was performed using the CB11 monoclonal antibody to HER2/neu oncoprotein. The staining intensity of this carcinoma was 1 on a scale of 0-3. Carcinomas with staining intensity scores of O or 1 are considered negative for over-expression of HER2/neu oncoprotein.. Those with a staining intensity score of 2 are considered borderline. We and others have observed that many carcinomas with staining intensity scores of 2 do not show gene amplification. All carcinomas with staining intensity scores of 2 are therefore submitted for FISH testing. The results of the FIsH test are issued directly from the molecular cytogenetics laboratory.. Carcinomas with staining intensity scores of 3 are considered positive for over-expression of HeR2/neu oncoprotein. Tumors in this category show an excellent correlation between the results of immunohistochemical and FiSH testing, and almost always show gene amplification. Page 4 of 8
+
+--- Page 5 ---
+Surgical Pathology - Working Draft The immunoperoxidase stain(s) reported above were developed and their performance characteristics determined by the They have not been cleared or approved by the U. S. Food and Drug Administration. The FDA has. determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for rescarch. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLiA") as qualified to perform high-complexity clinical testing. Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Vaginal/Cervical/Endocervical, Direct Final Diagnosis Vaginal/Cervical/Endocervical, Direct NEGATIVE FOR INTRAEPITHELIAL LESION OR MALIGNANCY. SPECIMEN ADEQUACY: Satisfactory for evaluation Transformation zone components are present. Specimen Ctass: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Endometrium, biopsy Final Diagnosis Endometrium, biopsy: Inactive endometrium; no evidence of hyperplasia or carcinoma.. _Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Endometrium, biopsy Final Diagnosis Endometrium, biopsy: Weakly proliferative pattern with gland and stromal breakdown.. .. Specimen Class: Status: Signed Out Accessioned Signed Out: Specimen(s) Received: Vaginal/Cervical/Endocervical, Direct Final Diagnosis. Vaginal/Cervical/Endocervical, Direct BENIGN CELLULAR CHANGES. Predominance of Coccobacilli consistent with shift in vaginal flora.. SPECIMEN ADEQUACY: Satisfactory for evaluation. Endocervical cells present  Paae S of 8
+
+--- Page 6 ---
+Surgical Pathology - Working Draft Specimen Class: Status: Signed Out Accessioned Signed Out: : Specimen(s) Received: Endometrium, biopsy Final Diagnosis Endometrium, biopsy: Proliferative endometrium with irregular maturation, no evidence of hyperplasia or carcinoma. . Specimen Class: : Status: Signed Out Accessioned Signed Out: Speclmen(s) Received: Vaginal/Cervical/Endocervical, Direct Final Diagnosis Vaginal/Cervical/Endocervical, Direct BENIGN CELLULAR CHANGES Predominance of Coccobacilli consistent with shift in vaginal flora.. SPECIMEN ADEQUACY: Satisfactory for evaluation. Endocervical cells present.. Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Left Breast, Fine Needle Aspiration Final Diagnosis Left Breast, Fine Needle Aspiration: 1. Benign cyst. See comment. 2. Fibrocystic change.  Specimen Class: Status: Signed Out Accessioned Signed Out: Specimen(s) Received: Endometrium, biopsy Final Diagnosis Endometrium, biopsy: Simple hyperplasia without atypia; see comment. Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Endocervical, Direct Final Diagnosis Endocervical, Direct BENIGN CELLULAR CHANGES Cytologically benign endometrial cells present in a postmenopausal woman. SPECIMEN ADEQUACY: Satisfactory for evaluation. Endocervical cells present.. Paor h nf 8
+
+--- Page 7 ---
+Surgical Pathology Working Draft Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: A: Probable polyps, B: Endometrium, curretage Final Diagnosis A. Endometrium, probable polyp, biopsy: Proliferative endometrium with focal simple hyperplasia, in part polypoid. B. Endometrium, curettage: 1. Proliferative endometrium with irregular maturation. 2. Focal simple hyperplasia. 3. Focal tubal metaplasia. Specimen Class: . Status: Signed Out Accessioned Signed Out: Specimen(s) Received: Endometrium, biopsy Final Diagnosis Endometrium, biopsy: Disordered proliferative endometrium with cystic and oncocytic changes and stromal breakdown; see note. Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Endometrium, biopsy Final Diagnosis Endometrium, biopsy: Disordered proliferative endometrium with focal stromal breakdown. QA Review(s) Consultation Obtained Status: Complete as of roblem? Reviewers: Result(s): Agree .elated specimen(s): Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: ENDOCERVICAL Finat Diagnoeis CELLULAR CHANGES WITHIN NORMAL LIMITS BENIGN Conversion Signed Out by Cytotechnologist ..Specimen Class: Status: Signed Out Accessioned Signed Out: Specimen(s) Received: A) ENDOMETRIAL BX Page 7 nf 8
+
+--- Page 8 ---
+Surgical Pathology - Working Draft Firal Diagnosis UTERUS, ENDOMETRIUM, BIOPSY: SECRETORY ENDOMETRIUM. SEE NOTE Conversion  MD END OF REPORT Paze 8 of 8
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diff --git a/output/text/105803dc-9934-42b8-b575-c7fea03202f4.txt b/output/text/105803dc-9934-42b8-b575-c7fea03202f4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fc44fec3c16c9ef1801cceb1bae13c718fda3d24
--- /dev/null
+++ b/output/text/105803dc-9934-42b8-b575-c7fea03202f4.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SURGICAL PATHOLOGY REPORT SPECIMEN Right colon, hemicolectomy. CLINICAL NOTES GROSS DESCRIPTION The specimen is received unfixed labeled right. hemicolectomy and consists of a right hemicolectomy specimen. The right colon measures 14.5 cm in length and up to 6 cm in diameter. There is an attached segment of ileum measuring 16 cm in length and 2.3 cm in diameter  There is a dilated attached vermiform appendix measuring 6.5 cm in length and up to 1.2 cm in diameter. There also are small bubble like structures on the. serosal surface of the cecum  resembling pneumatosis. There is a fungating mass that appears to originate in the area of the orifice of the appendix. It measures 4.3 x 3.5 cm and is 11 cm from the colonic margin of resection.  Sections after fixation and clearing. A portion of the tumor is taken for research purposes. Block summary: 1,2 margins of resection; 3,4 appendix; 5 origin of appendix; 6 serosal vesicles; 7-11 tumor; 12-19 lymph nodes. MICROSCOPIC DESCRIPTION Tumor type:  Colonic adenocarcinoma Tumor grade: 2 Tumor size: 4.3 cm Distance to nearest margin: 11 cm Level of penetration:  Carcinoma invades through the muscularis propria into pericolonic soft tissue. Margins of resection: Negative for malignancy Vascular invasion: No definite vascular invasion seen. Host response:  Moderate acute and chronic inflammation. Attached lymph nodes: There is no evidence of malignancy in any of 19 lymph nodes. Non-lymph node pericolonic tumor: Absent. pTNM Stage: T3 NO Other findings: Benign serosal mesothlelial cysts.. Fibrous obliteration of the distal appendiceal lumen..
+
+--- Page 2 ---
+DIAGNOSIS Colon, right, resection: Moderately differentiated colonic adenocarcinoma Note: Carcinoma invades through the muscularis propria into pericolonic soft tissue. There is no evidence of malignancy in any of 19 pericolonic lymph nodes. End Of Report
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diff --git a/output/text/1066b51f-ff33-4968-b64d-3c29a106a95f.txt b/output/text/1066b51f-ff33-4968-b64d-3c29a106a95f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f7e82c6a4dbd596a94968c68b47e171a4cbaf2c6
--- /dev/null
+++ b/output/text/1066b51f-ff33-4968-b64d-3c29a106a95f.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:87394A2B-7AF7-49E0-9ED0-6FFCC899EC38 TCGA-ED-A5KG-01A-PR Redacted Gross Description: Tumor is moderate-margins with 5x4x4cm in size, yellow-white, soft in cutting. section. Microscopic Description: Tumor cells form the trabecular patterns, or acinar or sheets or tubular patterns intervening in begnin hepatic tissue. The tumor cells retain apolygonal shape and have very irregular round vesicular nuclei with prominent nucleoli. The amount of cytoplasm are abundant and the cytoplasm is basenophilic or clear. Nuclei are irregularly large and hyperchromatic with prominent nucleioli. Mitoses are present. Tumor is necrotic and hemorrhage.. Diagnosis Details: Hepatocellular carcinoma, moderately-differentiated zcD-O-3 Comments: Carc unomc., h ypataellelar 8/70/3 Formatted Path Reports: LIVER TISSUE CHECKLIST S,te! Lver, Heotic i6S CLQ0 Specimen type: Lobectomy VJ 21113 Tumor size: 5 x 4 x 4 cm Focality: Not specified Histologic type: Hepatocellular carcinoma. Histologic grade: Moderately differentiated Tumor extent: Not specified Lymph nodes: Not specified Venous invasion: Not specified Margins: Uninvolved. Evidence of neo-adjuvant treatment: Not specified. Additional pathologic findings: Not specified. Comments: None
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diff --git a/output/text/106b7860-a932-41fe-b9bb-ff0e8f0e0537.txt b/output/text/106b7860-a932-41fe-b9bb-ff0e8f0e0537.txt
new file mode 100644
index 0000000000000000000000000000000000000000..581724c2a6b97debcbb7a7b201bc067ad1d971fd
--- /dev/null
+++ b/output/text/106b7860-a932-41fe-b9bb-ff0e8f0e0537.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+zeD-b-3 UUID:DA704AB1-8D08-48EC-9F62-A6B5E69E4DC7 Cu armr Adrenal Cer+cal 837of3 Redacted S.te: Adreral G'lard Cortex 0 74.0 QJ s/6/13 Procedure: L adrenalectomy Gross description: 7 x 6.5 x 4.5cm, 115g Diagnosis: adrenocortical carcinoma, paradrenal LN free of tumor, Kl67 20-30%, pT3 pN0 (0/1) pMx Rx Reference Pathology: none 4f2f3-pw idd;tnsl poH,Wuis =b Maligr Prouss-if cear passo uri l Uf u PsH- hay n+shpif Mu
+
+--- Page 2 ---
+Patient # from Tissue Source Site. Date of report Date of Surgery/specimen collection Site (confirmed to be adrenal) with laterality indicated Left Tumor size(s) 7x6.5x4.5 Histologic diagnosis ACC Lymph Node Status 0/1 Pathologic information T3,NO(O/1),Mx Weiss score 6
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diff --git a/output/text/10afe417-bf56-4de2-99bf-6936f82ed8c8.txt b/output/text/10afe417-bf56-4de2-99bf-6936f82ed8c8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e32828b9b24197ca86523e4b4b7f5682f28b0819
--- /dev/null
+++ b/output/text/10afe417-bf56-4de2-99bf-6936f82ed8c8.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TCGA #: Sample ID #: Diagnosis: This is a poorly differentiated adenocarcinoma of the sigmoid colon with a histopathological grade G3 differentiation, with ulceration and erosions of the inner tumor surface, with fine foci of necrosis, with peritumorous chronic recurrent inflammation, with tumor infiltration in the layers of the sigmoid colon wall as far as the pericolic fatty connective tissue, with carcinomatous lymphangiosis, with a regional Iymph node metastasis (1/15) and tumor-free overview sections from the resection margins. According to these prepared sections, the tumor spread of the sigmoid colon carcinoma corresponds to the tumor stage pT3, pN1 (1/15), MX, L1, R0 10+ ICs-0-3 Adnocnunon,Nos 814o/3 Sth: Sigmnd co|wc18.7 UUID:7DBAA2D8-44FA-4726-94DC-3AFCFBFF15D5 Redacted TCGA-AA-A01T-01A-PR
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diff --git a/output/text/10c65926-5ba5-44ae-94e8-52297d370755.txt b/output/text/10c65926-5ba5-44ae-94e8-52297d370755.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c371ada05cd721b46df7c5a770205b9e408fedfb
--- /dev/null
+++ b/output/text/10c65926-5ba5-44ae-94e8-52297d370755.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: FMP/SSN: DOb/Age/Sex: Specimen #: Location: Race: BLACK Physician(s) :. Taken: Received: Reported: SPECIMEN: /cs-0-3 A: LEFT BREAST B: SKIN FLAP Carcmomo,ifl1rsF:vg cuctrl,Nos 85ooJ7 S.t.brust, nos c50.9 FINAL DIAGNOSIS: /25/1 sh A. BREAST, LEFT, MASTECTOMY WITH AXILLARY TAIL: * TUMOR TYPE: INFILTRATING DUCTAL CARCINOMA, NO SPECIAL TYPE. * NOTTINGHAM GRADE: POORLY DIFFERENTIATED (G3). * NOTTINGHAM scoRE: 9 (Tubules= 3, Nuclei- 3, Mitoses- 3; mitotic count > 12 per 10 HPF at 40x power) TUMOR SIZE (GREATEST DIMENSION): 3.5 CM. (MEASURED GROSSLY). * TUMOR NECROSIS: PRESENT IN INFILTRATING COMPONENT. * MICROCALCIFICATIONS: ABSENT. * VENOUS / LYMPHATIC INVASION: ABSENT. * MARGINS: NEGATIVE. -DISTANCE OF TUMOR FROM NEAREST MARGIN IS 2.0 CM. (DEEP MARGIN).  INTRADUCTAL COMPONENT: ABSENT. * LYMPH NODES: TEN (1O) LYMPH NODES NEGATIVE FOR TUMOR. *  NIPPLE INVOLVEMENT: ABSENT. * SKIN INVOLVEMENT: ABSENT. * MULTICENTRICITY: ABSENT. * ESTROGEN RECEPTORS: NEGATIVE (REFER TO PRIOR SPECIMEN * PROGESTERONE RECEPTORS: NEGATIVE (REFER TO PRIOR SPECIMEN * HER 2 NEU by IHC: NEGATIVE, 1+ (REFER TO PRIOR SPECIMEN * PATHOLOGIC STAGE: pT2 NO MX. * ADDITIONAL PATHOLOGIC FINDINGS: -PERIDUCTAL CHRONIC INFLAMMATION. B. SKIN, LEFT BREAST, EXCISION: -UNREMARKABLE SKIN AND SUBCUTANEOUS SOFT TISSUE. -NO EVIDENCE OF MALIGNANCY. ** Report Electronically Signed Out ** UUID:D8844020-EC34-4788-B7F8-79089C12D886 TCGA-A2-A0D0-01A-PR Redacted 1 tAL DATA - PRIVACY ACT OF 1974 Continued on Next Page
+
+--- Page 2 ---
+TOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974S SURGICAL PATHOLOGY REPORTS Patient: Specimen #: CLINICAL DIAGNOSIS AND HISTORY:S -year-old female with breast cancer.. PRE-OPERATIVE DIAGNOSIS: Breast cancer. GROSS DESCRIPTION: A. Received fresh, labeled with the patient's name,. designated "LEFT BReasT" is a 1.466 gram, left mastectomy specimen oriented with a short stitch superior, long lateral, and double deep. specimen measures 31.0 cm medial to lateral, 23.0 cm superior to inferior, The and 6.0 cm anterior to posterior. The darkly pigmented, superficial skin ellipse measures 30.0 x 6.0 cm, and displays a 1.0 cm everted, centrally located, nipple free of discharge. No scars are noted. The deep margin is remarkable for scattered, irregular portion of attached red-brown muscle measuring up to 4.5 x 1.5 cm in greatest dimension. The deep margin is inked in black, and the superficial-lateral surface is inked blue. Serial sections reveal a 3.5 x 2.8 x 3.0 cm poorly defined mass in the mid-outer breast. On sectioning, the cut surface ranges from pink-white, and firm, to pink-white, soft, and cystic. Continuous, with, and deep to, this mass is a 2.0 x 2.0 x 1.9 cm smooth walled cyst containing serosanguineous fluid, consistent with the previous biopsy site. The cyst and mass are located 2.0 cm from the deep margin. remainder of the specimen is predominantly composed of lobulated, The yellow-tan, adipose tissue admixed with scant, fibrous tissue. No additional lesions are identified. Specimen subsequently placed in formalin for 32 hours. The attached axillary tail measures 13.0 x 9.0 x 3.0 cm. On sectioning, eight pink-tan, lymph nodes are identified which range in size from 0.8 x 0.5 x 0.2 cm to 3.0 x 2.0 x 1.0 cm. Representative sections are submitted. Cassette Summary: Al: Skin. A2: Mass. A3: Mass. A4: Mass and adjacent cyst.. A5: Normal adjacent to mass.. A6-A7: Deep margin closest to mass. A8: Upper outer quadrant. A9: Upper inner quadrant. Al0: Lower outer quadrant. All: Lower inner quadrant.. Page 2 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974S
+
+--- Page 3 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORTS Patient: Specimen #: GROSS DESCRIPTION (continued): A12: Largest lymph node.. A13-A14: Second largest lymph node.. A15-A16: One lymph node. Al7: Three lymph nodes.. A18: One lymph node bisected. A19: One lymph node bisected A20: Nipple. Matched sections of A1 through A3, A8 through A12, A13, A15, A20 are. submitted in Oct for cBcp protocol. 20cF B. Received in formalin for twenty-eight hours, labeled with the patient's. name, designated "skin FLAp" is an irregular, lobular fragment of soft tissue with attached brown skin forming a continuous ring. which measures 61.0 cm in circumference with the width of skin ranging from 1.5 cm at narrowest to 4.8 cm at widest. No lesions are seen on the. skin surface. Representative sections are submitted in one cassette. 1CF Page 3 End of Report FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974S
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diff --git a/output/text/10d18448-2c0b-4e09-86ef-a7552a624dee.txt b/output/text/10d18448-2c0b-4e09-86ef-a7552a624dee.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d6da38a8b6bbc398e3eea992983dad21b6fa842d
--- /dev/null
+++ b/output/text/10d18448-2c0b-4e09-86ef-a7552a624dee.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Pre-Operative/Clinical History Left renal mass. Specimen(s) Received A: MARGIN - BASE OF TUMOR, LEFT KIDNEY MASS B: LEFT RENAL MASS Gross Description Specimen A, received fresh.for frozen section labeled margin (base) of tumor, left kidney mass, consists of three friable tan soft tissue fragments that measure 0.2 to 0.5 cm in greatest dimension. The fragments are entirely submitted for. frozen section in (A1 FS). Specimen B, received in formalin labeled left renal mass, consists of a 12 gm, 4.0 x 4.0 x 2.5 cm aggregate of multiple pink, friable to papillary soft tissue fragments admixed with a small amount of adipose tissue. Representative sections are submitted in (B1-6). ntraoperative Consultation Specimen A, frozen section diagnosis of "neoplasm present in one of three fragments' is rendered by. Microscopic Description Sections of the-first specimen reveal a fragment of adipose tissue, a fragment of benign renal parenchyma, and a single small fragment of papillary renal cell carcinoma, as described below.. Summary of Pathologic Findings  Renal Carcinoma Specimen B: Operative procedure: Enucleation; robotically-assisted laparoscopic left partial nephrectomy. Tumor size: The specimen was received morcellated and measured 4.0 x 4.0 x 2.5. cm in aggregate. Clinically, the tumor measured approximately 2.7 cm in maximum dimension. Laterality and focality: Left, unifocal. Histologic type: Papillary carcinoma, type l. (The tumor demonstrates a papillary architecture with delicate fibrovascular cores lined by small cells with low grade nuclear features. Clusters of foamy histiocytes are present within Page 1 of 3
+
+--- Page 2 ---
+HISTOLOGY REPORT some of the cores. There is no evidence of necrosis or vascular invasion. The specimen contains small fragments of adjacent renal parenchyma.) Sarcomatoid features: Absent. Histologic grade:. Grade I. Extent of invasion: Cannot be determined. Lymph/vascular invasion: Cannot be determined. Margins: Cannot be assessed. Adrenal gland: Not submitted. Regional lymph nodes: Not submitted. Special studies:. The following immunostains are performed with the tumor cells staining as follows. Pax-8 Positive P504S Positive CK7  Positive CK20 Negative Vimentin Negative CD10 Negative TTF-1 Negative. These immunohistochemical features are compatible with a diagnosis of papillary renal cell carcinoma pTNM stage: The specimen was received morsellated, precluding an accurate pT'NM stage..Staging in this. case relies on the clinical imaging. Pathologic findings in nonneoplastic kidney: Insufficient.tissue. Diagnosis LEFT RENAL MASS, ROBOTICALLY-ASSISTED LAPAROSCOPIC LEFT PARTIAL NEPHRECTOMY: LOW GRADE PAPILLARY RENAL CELL. CARCINOMA. Intradepartmental Consult Comment Positive and negative controls react satisfactorily Page 2 of 3
+
+--- Page 3 ---
+HISTOLOgy REPORT EnD.OF rEpORT Page'3 of 3:
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diff --git a/output/text/10e7ad90-dbb7-4f40-9156-06c827e40cf6.txt b/output/text/10e7ad90-dbb7-4f40-9156-06c827e40cf6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5efdd3d63431990eb9f776c783ab4a67794e8476
--- /dev/null
+++ b/output/text/10e7ad90-dbb7-4f40-9156-06c827e40cf6.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Patient Key:. Surgical date:. TISSUE DESCRIPTION: Segments II and IIi left lobe liver (620 grams, 18 x 11 x 9.5 cm) and specimen from right lobe liver (biopsy, 1.3 x 0.8 x 0.3 cm). A1, B1, B2, B3, B4, B5, B6 DIAGNOSIS: Left liver, segments II and IlI: Grade 2 hepatocellular carcinoma is identified forming a yellow-white, multilobulated mass, 11 x 10 x 9.5 cm. Adjacent to the large mass, there is a separate tumor mass, 1.3 x 1.2 x 1 cm. The hepatic parenchyma is noncirrhotic and the margin of resection is free of involvement; closest surgical margin 0.5 cm. () J Right liver biopsy: Benign liver tissue JUID:646F2FE0-EA95-4758-8454-4B0E63855384 TCGA-DD -A3A5-01A-PR Redacted 150-0-3 ccICinvna,hupu$rulubuw N05 817o13 Site: lujucsz.o. /22/
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diff --git a/output/text/10ecb378-9f5d-48e0-ab73-19708ab34ac2.txt b/output/text/10ecb378-9f5d-48e0-ab73-19708ab34ac2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..503aa52f6b7586fdd19ee09a74c9b8d0d9ca4a79
--- /dev/null
+++ b/output/text/10ecb378-9f5d-48e0-ab73-19708ab34ac2.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+TCGA-CS-5394 SURGICAL PATHOLOGY REPORT FINAL DIAGNOSIS: 1. LEFT FRONTAL TUMOR: ANAPLASTIC ASTROCYTOMA, WHO GRADE III, SEE MICROSCOPIC DESCRIPTION 2. LEFT FRONTAL TUMOR: ATYPICAL GLIAL CELLS CONSISTENT WITH PORTION OF INFILTRATING ASTROCYTOMA, SEE DIAGNOSIS FOR SPECIMEN #1. This diagnostic report has been personally interpreted by the signatory. of record. Microscopic Description: The tumor consists of pleomorphic glial cells with eosinophilic. cytoplasm and moderately pleomorphic nuclei with ovoid to angular. contours. Multiple mitotic figures are identified in tumor cells. (siide 1B). The proliferation index as determined by nuclear staining with the Ki67 (MIB-1) immunohistochemical stain is focally 10% in areas of tumor on slide 1B. Frozen Section Diagnosis:. 1. LEFT FRONTAL TUMOR: GliaI neoplasm, final grading deferred to permanents. 2. LEFT FRONTAL TUMOR: GliaI neoplasm. No clear anaplastic features identified in this material. Frozen section diagnosis.
+
+--- Page 2 ---
+Cunical History and Diagnosis:. Left frontal tumor consistent with glioma. Nonenhancing lesion Source of Specimen: 1: LEFT FRONTAL TUMOR 2: LEFT FRONTAL TUMOR Gross Description: 1. LEFT FRONTAL TUMOR: Received fresh for frozen section are multiple fragments of soft tan pink tissue measuring 1.5 of 1.5 x 0.6cm in aggregate. Touch preps are made. Half of the specimen is submitted for frozen section diagnosis, the remaining specimen is submitted for permanent sections. 2. LEFT FRONTAL TUMOR: Received fresh for frozen section are multiple fragments of soft tan white tissue measuring 0.4 x 0.2 x 0.2cm in p-qregate. Touch preps are made. Half of the specimen is submitted. I.. frozen section diagnosis. The remaining specimen is submitted for permanent sections. Histology Laboratory H&E Part 1: LEFT FRONTAL TUMOR UNSTAINED
+
+--- Page 3 ---
+IMMUNOPATHOLOGY REPORT EVALUATION: Ki67: POSITIVE STAINING IN UP TO 1O% OF TUMOR CELL NUCLEI GFAP: POSITIVE STAINING IN TUMOR CHROMOGRANIN: NEGATIVE IN TUMOR CELLS Comment: The immunohistochemical stains support the diagnosis of Anaplastic Astrocytoma, WHO grade IIl. See corresponding surgical pathology report This diagnostic report has been personaly interpreted by the signatory of record.
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diff --git a/output/text/111ac39a-d0a0-4dfa-9d77-cecd1c6ca6a3.txt b/output/text/111ac39a-d0a0-4dfa-9d77-cecd1c6ca6a3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..672e708aa13cdf08db5e5d0a2fc3f8416dfd4c21
--- /dev/null
+++ b/output/text/111ac39a-d0a0-4dfa-9d77-cecd1c6ca6a3.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Curu.amr,1ohulw,N1s 8520/3 r^cF: bust Nos C5o 9 Patien 7 UUID:468892B9-82C8-4305-BCB9-805F6F5FC90A  Surg Path TCGA-B6-A0RQ-01A-PR 'Redacted CLINICAL HISTORY: Not provided. GROSS EXAMINATION: A."Right breast biopsy", fresh. The specimen is a 4.5 x 3.5 x 3.0 cm portion of yellow to grey-white soft tissue. According to the surgeon, the resection margins are not a concern, as a mastectomy is planned. The specimen is not inked. Cut surface shows an approximately 2.5 x 2.5 x 1.5 cm mass composed of firm white tissue with interspersed foci of adipose tissue. The mass extends to the operative margin over a wide area.. The specimen is otherwise composed. of unremarkable adipose tissue. A representative portion of the mass is submitted for frozen section..  Another representative portion is submitted for. hormone receptor analysis. BLOCK SUMMARY: Al frozen section remnant. A2-A4 further representative sections from the mass.. B."Breast tissue right side", fresh. The specimen is a 700 gram, 21 x 14 x 4 cm breast with an attached, approximately 9 x 9 x 1 to 2 cm portion of soft tissue in the axillary region. The breast includes a 17.5 x 10.5 cm elliptical portion of skin with a roughly centrally placed nipple and a 4.5 cm transverse incisional wound located superior, and slightly medial, to the nipple. The skin is uniformly smooth and tan-white, without erythema, induration or nodules. The nipple is likewise unremarkable. Cut surface reveals an approximately 6.0 x 5.0 x 4.5 cm cavity deep to the incisional wound. The biopsy cavity occupies the region immediately deep to the nipple and the adjacent upper inner quadrant. An approximately 3.5 x 3.5 x 2.5 cm mass is present alongside the biopsy cavity, involving tissue medial and deep to the biopsy cavity. The mass is composed of firm grey-white tissue which contains foci of yellow adipose tissue within it. The surgical resection margins are grossly free of the mass; toward the medial edge of the specimen, the mass extends to approximately 0.3 cm from the deep resection margin, with questionable extension to within 0.2 cm from the margin at this site. breast is otherwise composed of adipose tissue and grey-white glandular-  The appearing breast tissue, showing occasional firmer areas of white fibrous- appearing tissue, but no other discrete masses or nodules. Nine lymph nodes are identified in the lower portion of the axillary tissue, and nine lymph nodes are identified in the upper portion of the axillary tissue. The lymph nodes range up to 3.0 cm in greatest dimensions.. Some of the lymph nodes show replacement with adipose tissue, but they are otherwise grossly unremarkable. BLOCK SUMMARY: B1-2 deep resection margin at medial aspect of specimen (closest approach of the tumor to the margin). B3-4 medial resection margin. B5-6 representative sections of the mass, medial to the biopsy cavity.. B7 section from fibrous-appearing tissue, lateral to the biopsy cavity.. B8 representative sections from upper outer quadrant. B9 representative sections from upper inner quadrant. B10 representative sections from lower outer quadrant. Criteri B11 representative sections from lower inner quadrant.. B12 nipple. B13 representative portions of skin. B14-16 one lymph node in several parts , lower axillary region.. B17  one lymph node in three parts, lower axillary region.. B18 two lymph nodes, each bisected, lower axillary region; one lymph node is I of 2
+
+--- Page 2 ---
+inked. B19 four lymph nodes, each single, lower axillary region.. B20 one lymph node in several parts, lower axillary region. B21 several questionable lymph nodes, lower axillary region.. B22-23 one lymph node node in several parts, upper axillary region. B24  one lymph node in several parts, upper axillary region.. B25 two lymph nodes, each bisected, upper axillary region; one lymph node is inked blue, the other black. B26 four smaller lymph nodes, each single, upper axillary region. B27 highest axillary lymph node (marked with blue ink) and several other questionable lymph nodes, upper axillary region.. INTRA OPERATIVE CONSULTATION: Afl: "Right breast biopsy": Carcinoma DIAGNOSIS: A. "RIGHT BREAST BIOPSY*: INVASIVE LOBULAR CARCINOMA. B. "BREAST TISSUE RIGHT SIDE": INVASIVE LOBULAR CARCINOMA WITH A FOCAL CARCINOMA IN SITU COMPONENT. TUMOR SIZE: APPROXIMATELY 7.0 X 3.5 X 2.5 CM. INVASIVE CARCINOMA EXTENDS TO WITHIN 1 MM OF THE DEEP RESECTION MARGIN AT THE MEDIAL ASPECT OF THE SPECIMEN. LOBULAR CARCINOMA IN-SITU IS PRESENT IN DUCTS APART FROM THE TUMOR MASS (BLOCK B1O). BENIGN PROLIFERATIVE CHANGES INCLUDING: APOCRINE METAPLASIA AND DUCT ECTASIA. FOURTEEN AXILLARY LYMPH NODES, NONE OF WHICH CONTAIN METASTATIC CARCINOMA (0/14). Verified I, 2 of 2
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diff --git a/output/text/111bf3ba-7c79-427f-b9c5-30b61f393fd5.txt b/output/text/111bf3ba-7c79-427f-b9c5-30b61f393fd5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d3bf4c8c525afd501f809c225bd0c7530b9b374f
--- /dev/null
+++ b/output/text/111bf3ba-7c79-427f-b9c5-30b61f393fd5.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+JUID:468CD293-C9F7-43C6-A40A-18FCDD22F6AA V-01A-PR Redacted Final Diagnosis reast, right, wide local excision: Infiltrating ductal carcinoma, Nottingham grade II (of IIl) [tubules 2/3, nuclei 2/3, mitoses 2/3; Nottingham score 7/9], forming a mass (2.4 x 1.7'x 1.6 cm) [AJCC pT2]. Biopsy site changes are present. Ductal carcinoma in situ, solid and micropapillary type, intermediate nuclear grade, comprising 5-25% of the tumor mass. Angiolymphatic invasion is. identified. All surgical resection margins, after re-excision of the medial margin, are negative for tumor (minimum tumor free margin, 1.0 cm, inferior margin). Lymph nodes, right axillary sentinel Nos. 1 and 2, sentinel biopsy: A single (1 of 2) axillary sentinel lymph node is positive (for micrometastasis [AJCC pN1mi(sn)]), with 2 metastases, the Iargest measuring 1.0 mm and smallest 0.5 mm. Immunohistochemical cytokeratin stain was performed on the paraffin embedded sentinel lymph node tissue and confirms the. H&E impression. 1cs-0-3 Corciimmu, nifniltnutmy oluct nos85o0/3 Sth: brst Nos C50.9 4/as/I
\ No newline at end of file
diff --git a/output/text/1136be39-19e8-4471-b689-da9531a177a8.txt b/output/text/1136be39-19e8-4471-b689-da9531a177a8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7127d75b2418a55ee3af8f25d8a817e092307e02
--- /dev/null
+++ b/output/text/1136be39-19e8-4471-b689-da9531a177a8.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Ics-0-3 Carcinomn,nfiltnathg ductl, nos85oo/3 PsM Site: busst, cntryl C5o1 pohu CqcF Sife: brut Nos c5u.9 Diagnosis: Poorly differentiated invasive carcinoma with discrete in situ spread (tumor diameter 2.5 cm). Infiltration of the corial connective tissue of superficial adjacent skin spindle. No ulceration of the skin. Focal tumor spread within the lymph vessels. In conclusion, this is a poorly differentiated invasive ductal carcinoma.. Tumor classification: NOS, G IIl, pT2N1aL1V0R0 UUID:64F84FF4-A477-4E1E-B4BB-E5614517229E Redacted
\ No newline at end of file
diff --git a/output/text/113aba64-6cf8-4fd2-aa49-dc855edd2e5b.txt b/output/text/113aba64-6cf8-4fd2-aa49-dc855edd2e5b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..55ef6042a9e7cc36ef43523eb0c165bb791c8910
--- /dev/null
+++ b/output/text/113aba64-6cf8-4fd2-aa49-dc855edd2e5b.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+IOD.O  Patient Name: Med Rec. #: 3070|3 Site: C'arwy NOS Requested By: 0839 Ordered By fJ o/3i//4 Report Name: : Surg Path Case - sTATUs: Final UUID:E17EECA7-26DE-4456-94B2-6B5A9F4931AD **SEE NOTE Collect/Perform: TCgA-MY-A913-01A-PR Redacted Ordered By: Oxdered Date: Department: Physician who Performed Procedure: Requesting Physician: Attending Pathologist : DIAGNOSIS: Cexvix, biopsy: - Fragments of invasive poorly differentiated squamous carcinoma. - Orientation precludes measurement of depth of invasion.. cOMMEnr: There is a copious amount of sampled tissue, almost all of which is composed of tumor. A p63 stain is strongly positive supporting the diagnosis. CLINICAL INFORMATION Cervical cancer GROSS DESCRIPTION: The specimen is received fresh labeled "cervical biopsy*. It consists of a 2x0.7x0.4 cm irregular portion of tan rubbery tissue.. One aspect demonstrates apparent. tan smooth mucosa. The tissue is inked and serially sectioned. The cut surfaces are tan and smooth..  Also received are two tan rubbery tissue. fragments measuring 0.5 x.0.4 x 0.2 cm in aggregate.  The specimen is entirely submitted in three cassettes as follows: 1A-1B- largest portion of tissue, sectioned. 1C separately received tissue fragments. The following special studies were performed on this case and the. interpretation is incorporated in the diagnostic report above: 1 of 2
+
+--- Page 2 ---
+Patient Namc. Med Rec #:; Requested By: Ordered By Report Name: Electronic Signature **Electronically Signed Out by I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the final diagnosis(es).. Note: The histology. immunochemistry and in situ hybridization components Eor this case were performed at The Attending Pathologist reviewed this case and made the diagnosis.. Where applicable, immunohistochemistry and in situ hybridization tests were. developed and the performance characteristics determined by the. have not been cleared or approved by the Us Food and Drug Administration and the results should be correlated with other clinical and laboratory data. Appropriate controls were performed for all immunohistochemistry, in situ hybridization and histochemical tests. 12
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diff --git a/output/text/11884bbe-2fa3-411f-ad54-7d64265cbe8f.txt b/output/text/11884bbe-2fa3-411f-ad54-7d64265cbe8f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..55d6bf27171cc23f3c9f11a0b13e89cd529902ee
--- /dev/null
+++ b/output/text/11884bbe-2fa3-411f-ad54-7d64265cbe8f.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UID: 5C446B3A-D6FB-4301-97E9-D713F985FEBE TCGA-CF-A3MH-01A-PR Redacted trB approVeD 3 Clinical Case Report 1Cs-0 -3 (For Collection of Cancerous Tissue) Cackomu, Pap;l/ury wrothlil 813of3 7 S;hu>b1vdhv,Ncs Cl7.y HIPAAI Informed Consent I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the  RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator Signature Date Clinical Information GENERAL INFORMATION Date of Birth (mm/dd/yyyy) Height Marital Status Race Temperature  Single Married Gender Weight  Divorced  Widow  Blood Pressure Heart Rate AMale   Female 2/0 HISTORY OF PRESENT ILLNESS Chief Complaints: Lewer abxdominal pcy'n j -fever Symptoms: H emnotn`a : Wei ohf- los s. Clinical Findings: Performance Scale (Karnofsky Score):  100 Asymptomatic  80-90 Symptomatic but Fully Ambulatory  60-70 Symptomatic, in bed less than 50% of day  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden  20-30 Bed Ridden CURRENT MEDICATIONS Drug Dose Route Frequency Date (mm/dd/yyy) 1 To / To To To To
+
+--- Page 2 ---
+PAST MEDICAL HISTORY Diagnosis/Disease/Disorder/Injury  Diagnosis Date Treatment Status OB/GYN HISTORY Menopausal Status Date of First Menses. # of Pregnancies  Pre-menopausal  Peri-Menopausal Date of Last Menses # of Live Births  Post-menopausal Birth Control:  Condom  Oral Contraceptive  IUD  Hormone Replacement  Other: Therapy: SOCIAL HISTORY Occupatlon: Environmental Hazards: Smoking History Current Status TYPE Packs/day Duration When Quit. QYES QNO 1/ze I d cey. 50 (yrs) ill Sm(yr) Alcohol Consumptioy Current Status TyPE Drinks/day Duration When Quit YES NO [2 cmles/ dcuy (yrs) 3  smtls (yr) Drug Use Current Status TYPE Freguency Duration When Quit  yes  NO (yrs) (yr FAMILY MEDICAL HISTORY Relative Diagnosis Age of Diagnosis LAB DATA Test Result Date Test Result Date HIV SNegative  Positive: CEA  Negative  Positive: Hep B PNegative  Positive: 9/ CA 15-3  Negative  Positive: Hep C pNegative  Positive: CA 19-9   Negative  Positive: AFP   Negative  Positive: PSA   Negative  Positive: Other: Other:  Negative  Positive:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+DIAGNOSTIC STUDIES Study Results Date Ultrasound X-Ray CT Endoscopy MRI Biopsy CLINICAL DIAGNOSIS Preoperative Clinical Dlagnosis Location of Suspected Involved Lymph Nodes Location of Suspected Distant Metastasis Clinical Staging Date of Diagnosis NO MO T2 Stage: I 3 Treatment Information SURGICAL TREATMENT Procedure Date of Procedure Peseetw  Bladder Primary Tumor Organ Detailed Location Size Lpisrefy-bladalez OueR japppg le32 p Fbkaks xlS x / cm Extension of Tumof Lymph Nodes Description Locatlon of Lymph Nodes. # of Lymph Nodes Palpable, Non-Dissected Lymph Nodes. Dissected Lymph Nodes Distant Metastasis  Organ Detailed Location Size Surgical Staging T 2. No Stage:LP NEOADJUVENT THERAPY (Chemo, Radiation, Immuno, Hormonal, or Molecular)  Drug/Treatment Dose Route Freguency Date (mm/dd/yyyy) To To / To 1 To / To 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by: Date: Preserved by: Date: .Time: SPECIMEN TYPE (# of samples provided) Frozen Paraffin Block Blood/Serum/Plasma Slide Diseased Normal  Diseased Normal Diseased  Normal Diseased Normal 4 2 2 2 Time to LN2 Time to Formalin Time to LN2 min 72 min min PATHOLOGICAL DESCRIPTION Primary Tumor  Organ Size Extension of Tumor Distance to NAT x/ x cm Lymph Nodes Location # Examined # Metastasized Distant Metastasis Organ Detailed Location Size Pathological Staging pT 2 No m 0 Stage: IIg Notes: 4
+
+--- Page 5 ---
+consolidated Diagnostic pathology form* Microscopic Appearance: 1. Histological pattern: STRUCTURAL PATTERN +- CELL DISTRIBUTION Diffuse  Streaming Mosaic  Storiform Necrosis Fibrosis Lymphocytic Infiltration Palisading Vascular Invasion X Cystic Degeneration Clusterized Bleeding Myxoid Change Alveolar Formation Indian File Psammoma/Calcification 2. Cellular features: + Lymphomatous  Adenomatous Sarcomatous  Squamous Large Cel! X Glandular cell Round Cell Squamoid Cell  Fibroblast Small Cell Spindle Cell Cell Stratification  RS Cell/RS Like Osteoblast  Keratin Secretion Inflam. Cell Desmosome Intracyt. Vacuole Lipoblast Plasma Cell  Gland formation  Myoblast Pear! Otherwise Specified: D7oADGo7 PrSO7 Dx D7 2. Cellular Differentiation: Moderately Poor Well Nuclear Atypia: E. Nuclear Appearance Aniso Nucleosis Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity Nuclear Grade POpi11ERey Comments: Date Director, Rescarch Pathology , PATHOLOGIST STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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diff --git a/output/text/1192234d-26a1-453b-a05d-ff073c88400b.txt b/output/text/1192234d-26a1-453b-a05d-ff073c88400b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..12bf7c35d9956b3ed2c924db712759b23a12fdbc
--- /dev/null
+++ b/output/text/1192234d-26a1-453b-a05d-ff073c88400b.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1Ly-U-3 Adenocarcin me 8140/3 Nos Jire 4d: sigmoicl to1oN C18.7 UUID:6F683573-6437-4BA8-8DCB-91CE61567612 TCGA-DM-A1D0-01A-PR Redacted (First Tumor) Tumor Site: Sigmoid Distal Date of Cancer Sample Procurement Histology: Adenocarcinoma Description of other histology: Grade: Poorly Differentiated Mucinous:  No C Yes  Yes r Unknown (Focal) Signet Ring Feature: 6 No  Yes  Yes  Unknown (Focal) Histologic Heterogeneity: r No  Yes C Unknown Host Response: None Crohn's like reaction  None C Yes C. Unknown Plasma cell rich stroma C No C Yes ( Unknown Growth Pattern: C Expansile C Expansile 6 Invasive C Unknown  and Invasive Inflammatory Bowe! Disease 6 No C Yes C Unknown Angiolymphatic Invasion: C No C Yes C Unknown Mutator Phenotype: 6 No  Yes C Unknown Number of Slides 1 Garland Necrosis present: C Yes C No  Yes r Unknown (Focal) TIL Cells / HPF 2 Pathologist Comment:
\ No newline at end of file
diff --git a/output/text/11a7d019-707f-4fc7-a2d9-3e7e8b42cbe0.txt b/output/text/11a7d019-707f-4fc7-a2d9-3e7e8b42cbe0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9972e24bf6de617a125e63daa27311db6173599d
--- /dev/null
+++ b/output/text/11a7d019-707f-4fc7-a2d9-3e7e8b42cbe0.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+FINAL DIAGNOSIS: s part 1: Lymph node, retromammary, excisiOn  NO EVIDENCE OF METASTATIC MAMMARY CARCINOMA IN ONE LYMPH NODE (0/1) Part 2: Leet breast, total mastectomy -  INVASIVE DUCTAL CARCINOMA. B.* nOttinghAm GrADe iI (tubuLe fORmAtiOn 3, nUCLear PLeOmOrphISm 2, mITOtiC ActIvIty 1; ToTal SCOre 6(9). C.  INVASIVE TUMOR MEASURES 1.5 CM IN MAXIMUM DIMENSION. D. DUCTAL CARCiNOMA IN SITU (DCIS), NUCLEAR GRADE 3, SOLID PATTERN WiTH MODERATE COMEDO nECROSiS; DCiS COnSTiTutES 30% Of the tOTal TumOr mASS AND iS PRESEnt ADmiXed AnD AWAY FROM THE INVASIVE COMPONENT.  NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED. CASE SYNOPSIS: 1cs-0-3 SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST carunmu mfiAtnuHmy cutl,nos 85os|3 LATERALITY: Sit: brest, No3 c50.9 Left 3/13/n pROCeDUrE: Segmental LOCATION: Not specified SIZE OF TUMOR:  Maximum dimension invasive component: 1.5 cm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: No TUMOR TYPE (invasive component): Ductal adenocarcinoma, NOS NOTTINGHAM SCORE: Nuclear grade: 2 Tubule formation: 3 Mitotic activity score: 1 Total Nottingham score: 6 Nottingham grade (1, 2, 3): 2 ANGIOLYMPHATIC INVASION: No DERMAL LYMPHATIC INVAS!ON:  Not applicable CALCIFICATION: Yes, malignant zones Tumor type, in situ: Solid DCIS admixed and outside of invasive carcinoma component SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No Distance of invasive tumor to closest margin: 5 mm SURG MARGINS INVOLVED BY IN SITU COMPONENT: No LYMPH NODES POSITIVE: Distance of in situ disease to closest margin: 5 mm LyMPH NODES EXAMINED: 0 METHOD(S) OF LYMPH NODE EXAMINATION: 2 SENTINEL NODE METASTASIS: H/E stain  NON-NEOPLASTIC BREAST TISSUE: ADH, Other: biopsy site changes No t Stage, patholOgiC: N StagE, PathOlOgIC: pT1c m stage, pathologic: pN0 ESTROGen rECepTORS: pMX PROGESTERONE RECEPTORS: positive HER2/NEU: positive Comment: 2+ Refer to prior left breast core biopsy specimen, documented infiltrating duct carcinoma, nuclea yraue z. ), which UUID: 24245506-25BA-411D-8A43-S2D88F686037 Redacted TCGA-BH-A0BQ-01A-PR circle f+3/n
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diff --git a/output/text/11b5e7b0-88b8-4f15-b7b8-e4d7139b9c2f.txt b/output/text/11b5e7b0-88b8-4f15-b7b8-e4d7139b9c2f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..969d32b6e57cabc4340e42617e81dae62d868bca
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1c0-0-3 Carcinonin,mfiltratng duct, Nos 850vfz PATIENT HISTORY: + DATE of LMP: * Sit wd: brast, Nos C50.9 DATE OF LAST DELIVERY: PRE-OP DIAGNOSIS: RIGHT BREAST CA POST-OP DIAGNOSIS: SAME OPERATIVE PROCEDURE: RIGHT MODIFIED RADICAL MASTECTOMY CLINICAL HISTORY: MATERIAL SUBMITTED: RIGHT (MOD) RADICAL MASTECTOMY, PROCUREMENT BY SURGICAL PROCEDURE FINAL DIAGNOSIS: FINAL DIAGNOSIS: TRICHS. MODIFIED.RADICAL MASTECTOMY : CROSS REFER  VOLUMS MARGINS FREE OF TUMOR  NIPPLE NEGATIVE FOR PAGET'S DISEASE NOTE: eR/PR immunoperoxidase assay and Her-2/NBU testing will be performad on block "M4". ESTROGEN/PROGESTERONE RECEPTORS AND HER-Z/NEU PERFORMED ON RIGHT BREAST TISSUE BORDERLINE HSCORE: <= 15 NEGATIVE > 15 <= 30 BORDERLINE 30 POSITIVE HER-2/NEU - DAKO HERCEPTEST: A STRONG COMPLETE MEMBRANE STAININC IS OBSERVED IN MORE THAN 1O4 OF THE TUMOR UUID: 46DE21ED-1E08-4095-9B68-88D10AC74673 TCGA-Bh-A18R-01A-PR Redacted
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diff --git a/output/text/11bc525b-2ed2-4679-9aab-dbf8e85a65d8.txt b/output/text/11bc525b-2ed2-4679-9aab-dbf8e85a65d8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..349b11189442af0089589d5c03befa8285066761
--- /dev/null
+++ b/output/text/11bc525b-2ed2-4679-9aab-dbf8e85a65d8.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis: This is an adenocarcinoma of the colon, poorly differentiated, with a partial mucinous component, corresponding to G3, with infiltration of the muscularis and the vessels, corresponding to L1, V1, with free resection margins in the area of the mucosa and in the deep resection margin area, as well as lymph nodes in two sections with metastases of the carcinoma described corresponding to pN1. Tumor classification: ICDO-DA M-8140/3, G3, pT2, L1, V1, pN1 (2 of 12), locally R0, M classification in the context of an oncology. conference.
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diff --git a/output/text/11c609c5-af1e-4106-a087-f25360dfcdde.txt b/output/text/11c609c5-af1e-4106-a087-f25360dfcdde.txt
new file mode 100644
index 0000000000000000000000000000000000000000..20228694067e21c8ce38ed3e57379ee0b683d328
--- /dev/null
+++ b/output/text/11c609c5-af1e-4106-a087-f25360dfcdde.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+/c5-0-3 CaVtiomn,infilfrstng ouctul, Nos 85oof3 3te.Srast, Nos C 5g.4 //05/ 2. Invasive ductal breast carcinoma (maximum diameter 1.8 cm, malignancy grade II) with angioinvasion and infiltration of the neural sheath in the tumor periphery. Likewise in the tumor periphery a concomitant DCIS (malignancy grade II, procomponent of tumor < 10%). Distant fibrocystic parenchyma of the breast with fibroadenoma buds free of tumor and/or DCIS. Tumor classification: G2 (L1, V0), pT1c, pN0 (sn), MX, R0 (minimum width of dorsocranial safety margin I cm!). A211E1 Redacted
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diff --git a/output/text/11c79248-bb53-467c-b9e6-26f54e9cb438.txt b/output/text/11c79248-bb53-467c-b9e6-26f54e9cb438.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d0d21ac5874b7a517940d975cabef1a5b460d896
--- /dev/null
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+
+--- Page 1 ---
+Surgery Date TCGA-CJ-4905 DIAGNOSIS (A) RIGht KiDNEY: RENAL CELL CARCINOmA, CONVENTIONAL (CLEAR CELL) TYPE, FUHRMAN'S NUCLEAR GRADE 2. (SEE COMMENT) TumoR measures 3.8 Cm In mAxImum DImensiOn. Vascular, ureteral and soft tissue margins of resection free of tumor. Adrenal gland, no tumor present. COMMENT Histologic sections show tumor focally pushing into but not directly invading the renal sinus adipose tissue. In a few areas, only a thin rim of fibrous tissue separates tumor and sinus adipose tissue. GROSS DESCRIPTION (A) RIGHT KIDNEY - A specimen of right kidney (14.0 x 6.0 x 3.5 cm) with surrounding adipose tissue, overall 20.0 x 12.0 x 5.0 cm. Palpation reveals a firm nodular region in the lower pole. The specimen is opened along the ureter and bivalved to reveal a 3.8 x 3.5 x. 3.0 cm tumor that abuts the renal sinus and extends to within 5 mm from the surface of Gerota's fascia. The tumor is confined within the kidney and appears to be generally well circumscribed. The cut surface of this tumor is variegated, bright-yellow, cystic, with dark-  brown hemorrhagic areas. A portion of unremarkable adrenal gland measuring approximately 2 cm x 2 cm x 0.5 cm is also identified at the superior pole of the adipose tissue. The 10 cm segment of ureter is up to 0.5 cm in diameter, and is unremarkable. INK COdE: Black - surface of Gerota's fascia overlying tumor. SECTION CODE: A1, vascular and ureter margins; A2, adrenal gland; A3-A9, tumor adjacent to renal sinus; A10-A13, adjacent tumor with renal parenchyma; A14, tumor closest to inked surface; A15, normal renal parenchyma. Representative tumor and normal kidney are submitted to tumor bank. CLINICAL HISTORY SNOMED CODES T-71000, M-83123
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diff --git a/output/text/123fc768-27aa-43d6-a2c0-0ceecc3bb8c6.txt b/output/text/123fc768-27aa-43d6-a2c0-0ceecc3bb8c6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ca36f855ae6a3e7e662d62cddb278661bf17fbc9
--- /dev/null
+++ b/output/text/123fc768-27aa-43d6-a2c0-0ceecc3bb8c6.txt
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+
+--- Page 1 ---
+Surgery Date: TCGA-CJ-4889 Pathology Report DIAGNOSIS (A) "SUBCUTAneOUS InVASIVE CYSt": Follicular cyst, infundibular type. (See comment) (B) left kidney: RENAL CELL CARCINOMA, CONVENTIONAL (CLEAR) CELL TYPE, FUHRMAN'S NUCLEAR GRADE 4 (4.0 CM). Tumor confiNed To the kidney. Margins of resection free of tumor. Vascular and ureteral margins of resection free of tumor.. One hilar lymph node, no tumor present.. Benign renal cyst. (C) 11TH RIB: Segment of rib, gross diagnosis only. GROSS DESCRIPTION (A) SUBcuTANEOUS INVASIVE CYST - A tan-pink nodular soft tissue specimen (3.5 x 3.0 x 2.7 cm), consistent with a thin-walled ruptured cyst containing tan cheesy material. Specimen is representatively submitted in A1 and A2. (B) LEFT KIDnEy - A nephrectomy specimen (15.0 x 8.5 x 6.5 cm). A reddish-brown tumor mass (4.0 x 4.0 x 4.0 cm) with yellow areas is present in the mid lateral portion of the kidney. The tumor abuts the renal capsule without apparent involvement of the adipose tissue. It is 0.5 cm from the closest external surface. No renal sinus or renal vein involvement is identified. The remainder of the renal parenchyma has a 0.5 cm cortical cyst. Representative portions of tumor and normal tissue are submitted for tumor banking. The tumor is submitted for electron microscopy. INK CODE: Black - closest external surface overlying the tumor.. SECtiON cODe: B1, renal vein, artery and ureter margins; B2, one hilar lymph node; B3-B13, representative sections of tumor (al! yellow areas submitted; B5-B6, have closest external surface); B14, sections of kidney with renal sinus; B15, section of the cortical cyst. (C) 11TH RlB - A tan-pink non-oriented irregular fragment of rib (3.0 x 1.5 x 0.4 cm). The specimen is entirely submitted for gross only. CLINICAL HISTORY None given. SNOMED CODES T-71000, M-83123
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diff --git a/output/text/1241b39f-ec7d-4a19-ba3d-e32d2b97f4c3.txt b/output/text/1241b39f-ec7d-4a19-ba3d-e32d2b97f4c3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a937fe6507f14c597a92f086d13ea9f17296b2c4
--- /dev/null
+++ b/output/text/1241b39f-ec7d-4a19-ba3d-e32d2b97f4c3.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+Results Viewer Page I of 5 UUID:A3D8888A-51FB-44D2-8E24-096107D60058 TCGA-K4-A3WV-01A-PR Redacted MRN  Name Encounter Number COPY ONLy DO NOT FILE SURGICAL PATHOLOGY Time Collected Time Received Time Reported Order Number Ordering Provider  Status  Results Final Sonrce ct specinen A. IEET IFLVIC LYMPH NODES B. FIGHT FELVIC LYMPH NODES C. LEFT DISTAL URETER -FS- D. FEGHT DISTAL URETER -FS- E. FLADDER UTERUS, FALLOPTAN TUBES, OVARIES, ANTERIOR VAGINALS WALL- F. MESENTERIC LYMPH NODE icd-0-3 carcinomg,unteh'a1, Nos F"NAL DIAGNOSTS: 8120J 3 A. LEFT PELVIC LYMPH NODES- NO CARCINOMA SEEN IN THREE LYMPH NODES (O/3). Sit:3iackder, NOs B. RAGIT PELVIC LYMPH NODES- Cu7.4 5u-1Z NO) CARCINOMA SEEN IN THREE LYMPH NODES (O/3). C. LEET DISTAL DRETER -ES- Rp NO) SARCINOMA SEEN. D. RIGHT DISTAL URETER -FS- NO CARCINOMA SEEN. E. BLADDEP JTERUS, FALLOPIAN TUBES, OVARIES, ANTERIOR VAGINAL WAL INVASIVE CARCINOMA, HIGH GRACE. TUMOR SLTE: APEX, URINARY BLADDER HISTOLOGIC TYPE: UROTHELIAL. SQUAMOUS DIFFERENTTATION: FOCALLY PRESENT. GLANDULAR DTEFERENTIATION:  NOT PRESENT. Pre.
+
+--- Page 2 ---
+Page 2 of 5 Results Viewer - TUMOR SIZE: 3. CM. HESTOLOGIC QRADE: 3/3. DEPTH OF INVASION: OUTER LIMIT OF MUSCULARIS PROPRIA INEARLY H00). SEMC :MEN TYIE: RADTCAL. CYSTECTOMY, TOTAL ABDOMINAL HYSTERECTOMY AND PILATERAL SALPINGO-OOPHORECTOMY. TNM STAGE: pT2b, pNO, pMX. ,YMFH NODE(S) INCLUDED IN ALL PARTS: NUMBER INVOLVED : 0 NUMBER EXAMINED:  7 LYMPHATIC (SMALL VESSEL) INVASION:  NOT SEEN. ASSOCIATED EPITHELIAL LESIONS: UROTHELIAL CARCINOMA IN SITUS ADENTIFIED. NO TUMOR SEEN AT MARGINS. ATROEHITE: OVARIES WITH CORT ICAL INCLUSTON CYSTS. RUATERAL. BENIAN PARATUPAL CYSTS. ATROPHEC ENDOMETRIUM. LEIOMYOMAS. S. MFSENTERIC LYMPH NODE- NO CARCINOMA SEEN IN ONE LYMPH NODE (O/1). Hiqned Others rozen Section A. LEFT AND RIGHT DISTAL URETERS: NO CARCINOMA SEEN. Frozen section pertormed by Dr. Has: slinical Information SADLER TUMOR oss tescription A. Rrcetved in formalin labeled with the. +ent's name and Prepar.
+
+--- Page 3 ---
+Results Vicwer. Page 3o ? "-oft polvic lymph nodes" is an aggregate ot lobulated 1.brcadipose tissue measurirg 3 x 3 x 3 cm in cempact aqgregate.  Throe potontial lymph nodes are biseeted and Separately submitted in Al-A3. 3. Receiven in formalin labeled with the patient's name and. "xiyht pe:lvic lymph nodes" are multiple fragments of lobulated fibroadiguse tissue measuring 3 x 3 x 3 cm in compact agregate. Throe potential lymph nodes are biseuted and Saparately submitted in Bt-B3. t. Reseived in formalin labeled with the patient's name and "tott dietal ureter Fs" are two brown-tan tissues, each Ioastring 4 x 3 mun. Material. totally submitted in Ci. b. Hecerved in tormalin tabe.ed with the patient's name and "right dista! ureter Fs" is Irregular gray-tan tissue measuring 6 z 5 x I mn thick. Specimen totally submitted in Dl. E. Receivei in lormalin laboled with the patient's nae and "tladier, uterus, fallopian tube, ovaries, anterior vaginal Wali" is . soecinon r.o ir.clude the described organs, measuriny I: :m surerior to inferior, 9 cm anterior to posterior, 9 mht te jett. Th+ specimen has been inked blue on the riqht, biack on che lert. The b.adder cavity measures 2 cn tight. to Iett, . wn supertor to inferior, l.5 cm anterior to postericr. Thr il.dder muaosn is congested and edematous, and a conspicuous, firm, uniformly pale tan, bulging tunor i; noted at the apex.  The tumor measures 3.5 x 3.5 x 3.5 cm in greatest dumensions. The right and left ureters are deeply retracted and aze not sampled since their resection nargins are demonstrated in "g" and "p". The specimen includes the urethra, measuring 3 em in length, and the anterior vaginal wall, measuring 6 cm superior to interior and up to 3.5 cn in width superiorly with the anterier vaginal wall and distal urethra connected by d ndrrow strio of  mucosa. The included uterus is 6.5 cn superior Ie inf-rior, 1 om righr to left, and 3 cm anterior to pesterior. The cervix is 3 cm in diameter with a linear 6 ren ,.. Ihe riqht. tallcpian tube is 5 x 0.3 cm. Right ovary is noumally atrophic and measures 1.5 x 1.5. x 0.9 cm. The lett. tallopiar. tube is 4 x 0.3 cm in diameter. Normally atrophic l:ft. ovary measures 1.5 x 1 x 0.7 cm. The erdometrial cavity is; q.storted by dn apparent anterior 1.4 cm fibroid-like tumor with tto: savary moasuring 1.2 cm in wiath and 1.5 cin ir. length. The tiorettium appoars pale tan and appears to measure less than i. mr. rhi:k. A possiblc socond subserosal fibroid is noted at the left posterior aspect. Section code: El-shaved di.stal cunection rargin xo include distal urethra and inferior aspect ot onteriox vaginal wall; E2-E4-additional cross sections qrethtn te vayinal wall proceeding inferior to superior to) in.lud. maj rity of urethra; E5-shaved residual loft vaginal wall rese:tion margin: E6-shaved residual right vaginal wal! Prepared f
+
+--- Page 4 ---
+Results Viewer - Pagc 4 of 5 resection margin; E7-E8-ent.ire left tube and ovary:. E9-Elo-onsire right tube and ovary; Ell-duplicate sections of postorior cervix; E12-E13-duplicato full thickness sections postetior uterine wall to include l.2 cm fibroid-like tunor; tlt-ar-cri:r corvix including anterior vagina. wall;. Mlh-an.erior uterine wall fu'l thickress section: F:seanterior Subserssal fibroid-like tumor; E17-E20-bladder dome tt.nor in: relationship to inked surgical margin and inked free peritoneal. surfacg and comes within 3 mm of the inked right lateral surgigal resection margin (E2o). . Recsived in formalin labeled with the patient's na!e and "nesenseric lymph node" is a moderately firm yellow-tan tissue measuring 4 mm in greatest dimension..  The specimen is totally sunit.ed in Fl. rrocaure A. AA KOUTINE H&E X1 BLOCK.1 HVE X1 A. AA ROUTINE H&E X1 BLOCK.2 H&E X1 A. AA ROUTINE H&E XL BLOCK.3 HEE X1 R. AA ROUTINE H&E X1 BLOCK.1 B. AA ROITINE HSE X1 BLOCK.2 H&E y1 B. AA ROHITINE H&E XI BLOCK.3 HAEX1 . AA ROUTINE HSE XL BLOCK H&E X1 D. AA ROUTINE HSE X1 BLOCK H&E X1 E. AA ROUTINE HAE X1 BLOCK.1 H&E X1 E. AA ROUTINE H&E X1 BLOCK.2 H&E X1 K. AA kOUTINE H&E X1 BLOCK.3 HE YI. M. AA ROUTINE HSE XI BLOCK.4 HGE X1 E. AA ROUTINE H&E X1 BLOCK.5 HF YI AREUTS E. AA ROUTINE HSE X1 BLOCK.6 HSE X1 E. AA ROUTINE HE X1 BLOCK.7 H&E X1 Prepared for?
+
+--- Page 5 ---
+Results Viewer -. Page > of -. 3. AA ROUTINE HSE XL BLOCK.8 Ha. X1 E. AA ROUTINE H&E XL BLOCK.9 Haz 3! R. AA ROJTINE HsE X1 BLOCK.10 HaE X1 E. AA RO.JINE HaE XI BLOCK.11 1sEX1 F. AA POJTINE H&E X1 BLOCK.12 HSE X1 F. AA ROUTINE H&E X1 BLOCK.13 Ho. X1 R. AA RJTINE H&E XI BLOCK.14 HAT X1 F. AA ROJTINE HtE X1 BLOCK.15 HA: Y1 F.. AA ROITINE HSE X1 BLOCK.16 E. AA ROUTINE H&E XI BLOCK.17 HaR XI A RECUTS F. AA ROXITTNE HSE X1 RLOCK.18 Has 31 F. AA ROUPTINE HISE XI BLOCK.19 Hae 31 E. AA FOUTINE HEE X1 BLOCK.20 HSF K1 F. AA ROUTINE HSE XL BLOCK HSE XT Prepared for ?e
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diff --git a/output/text/126fd3d8-87e9-468e-acb2-b91782f99978.txt b/output/text/126fd3d8-87e9-468e-acb2-b91782f99978.txt
new file mode 100644
index 0000000000000000000000000000000000000000..af249c326949efb7a70b7602691209d2fd42bbdc
--- /dev/null
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@@ -0,0 +1,27 @@
+
+--- Page 1 ---
+1cD-0-3 UUID:1CEBF20D-767A-4A19-AA41-B9EAFCF05176 'tcGA-E2-A158-01A-PR 'Redacted Carcinna, mfiltrating oluct, N0S 85003 128/10 C.50.4 Pth Sif, cde:breast yppr on*w fuindrant CQeF Sit: hrut,N0s C5o.q TSS: SPECIMENS: A. SENTINEL LYMPH NODE #1 LEFT AXILLA B. SENTINEL LYMPH NODE #2 LEFT AXILLA C. LEFT BREAST D. SENTINEL LYMPH NODE #1 RIGHT AXILLA E. RIGHT BREAST SPECIMEN(S): A. SENTiNEL LYMPH NODE #1 LEFT AXILLA B. SENTINEL LYMPH NODE #2 LEFT AXILLA C. LEFT BREAST D. SENTINEL LYMPH NODE #1 RIGHT AXILLA E. RIGHT BREAST IntrAOpERATivE COnSULTATiOn DIAgNOSiS: TPA, Sentinel lymph node #1, left axilla: Negative for carcinoma TPB, Sentinel lymph node #2, left axilla: Negative for carcinoma Diagnosis called at by Dr. TPC, Sentinel lymph node #1, right axilla: negative for carcinoma Diagnosis called at . by Dr. GROSS DESCRIPTION: A. SENTINEL LYMPH NODE #1 LEFT AXILLA Received fresh labeled with the patient's identification and designated "sentinel lymph node number one left axilla" is a fragment of fibroadipose tissue, 1.4 x 1 x 0.6 cm, consisting of one possible lymph node, 1.4 x 0.7 x 0.4 cm. Touch preparation is performed. The entire lymph node is submitted, A1. B. SENTINEL LYMPH NODE #2 LEFT AXILLA Received fresh labeled with the patient's identification and designated "sentinel lymph node number two left axilla" is a fragment of fibroadipose tissue, 2 x 1.4 x 0.8 cm, consisting of one possible lymph node, 2 x 0.9 x 0.5 cm. Touch preparation is performed. The entire lymph node is submitted, B1. C. LEFT BREAST Received fresh labeled with the patient's identification and designated "left breast" is an oriented (suture in axilla), 573-g, 25 x 18 x 4.5 cm mastectomy specimen with 3.5 x 2 cm light tan skin ellipse, and 1.4-cm diameter everted nipple. Ink code: Posterior-black, anterior/superior-blue, anterior/inferior-orange. The specimen is serially sectioned from lateral to medial revealing a tan stellate mass in the U0Q (slices 3-4), 3 x 2.8 x 1.5 cm, located 0.2-cm from the nearest anterior margin, and 2.2-cm from the deep margin. A smaller well defined nodule present in the posterior UIQ is seen. A portion the specimen is submitted for tissue procurement. Representatively submitted: C1-C3: Nipple, C3 contains representative section of skin C4: Mass with anterior margin, slice 3, UOQ C5: Mass with anterior margin, slice 4, UOQ C6-C7: Remainder of mass, slice 4, UOQ C8: Deep margin, slice 4, UOQ C9: Additional section, UOQ, slice 5 C10: Representative section, LOQ, slice 5 C11-C12: Representative sections, UIQ, slices 7-8, respectively. C13: Representative section, LiQ, slice 7 C14-C15: nodule in posterior UIQ D. SENTINEL LYMPH NODE #1 RIGHT AXILLA Received fresh labeled with matching patient identifiers is a piece of adipose tissue 3.4 x 3 x 1.1 cm containing two lymph nodes, the smaller is 0 .5 cm in diameter, larger one measures 2.4 x 0.8 x 0.8 cm. Touch preps are performed the specimen is submitted entirely/separately in cassettes D1-D2. E. RIGHT BREAST Received fresh labeled with the patient's identification and "right breast" is an oriented 454 g, 19 x 16 x 3 cm mastectomy with 3 x 3 cm skin ellipse and 1.8 cm everted nipple. Ink code: Anterior/superior-blue, anterior/inferior- orange, posterior-black. Specimen is serially sectioned into 9 slices from medial to the lateral with nipple in slice 4 revealing 4 lesions. 1- 1.3 x 0.8 x 0.5 cm firm tan mass located in slics 5-6 in the upper outer quadrant; 2.7 cm from the deep margin and 0.2 cm from the anterior margin. 2- 1.2 x 0.9 x 0.8 cm firm tan stellate mass with central area of hemorrhage located in the upper mid-quadrant; 2.5 cm from the deep margin, 1.8 cm from the anterior margin, 1.4 cm the medial to lesion #1, and 1.8 cm. posterior/superior from nipple 3- 0.6 x 0.3 x 0.3 cm firm tan nodule located in the upper inner quadrant; 1.2 cm from the deep margin, 0.9 cm from the anterior margin and 3.2 cm medial to lesion #2
+
+--- Page 2 ---
+4- 0.6 x 0.4 x 0.2 cm firm tan nodule located in the lower inner quadrant; 1.2 cm from the deep margin, 0.6 cm from. the anterior margin, and 6.2 cm inferior to lesion #1 Representatively submitted.. E1: slice 1, upper inner. E2-E3: slice 2, lesion #3(posterior to anterior) E4: slice 3, tissue connecting lesion #3 and #2 E5-E7: slice 4, lesion #2 submitted anterior to posterior E8: slice 5, lesion #1. E9: slice, 6, lesion #1. E10: slice 7, upper outer (lateral to lesion #1) E11: slice 7, lower outer E12: slice 6, lower outer E13-E14: slice 5, lesion #4 (anterior to posterior) E15-E16: slice 5, tissue connecting lesions #1 and #4 E17: slice 3, lower inner E18: slice 2, lower inner E19-E21: nipple, perpendicular sections E22: skin DIAGNOSIS: A. LYMPH NODE, SENTINEL #1, LEFT AXILLA, EXCISION - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1) B. LYMPH NODE, SENTINEL #2, LEFT AXILLA, EXCISION: - METASTATIC CARCINOMA TO ONE OF ONE LYMPH NODE (1/1), MEASURING 0.1-CM (MICROMETASTASES) WITH NO EXTRANODAL EXTENSION, SEE NOTE C. BREAST, LEFT, MASTECTOMY: - TWO FOCI OF INVASIVE DUCTAL CARCINOMA - S8R GRADE 3, MEASURING 1.6-CM - SBR GRADE 1, MEASURING 0.5-CM - INTERMEDIATE NUCLEAR GRADE, DUCTAL CARCINOMA IN SITU, SOLID TYPE WITH CENTRAL NECROSIS AND MICROCALCIFICATIONS - SURGICAL RESECTION MARGINS NEGATIVE FOR TUMOR - BIOPSY SITE CHANGES WITH FIBROSIS AND GRANULATION TISSUE - SEE SYNOPTIC REPORT AND SEE NOTE D. LYMPH NODE, SENTINEL #1, RIGHT AXILLA, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1). E. BREAST, RIGHT, MASTECTOMY: - TWO FOCI OF INVASIVE DUCTAL CARCINOMA - SBR GRADE 3, MEASURING 1.1-CM - SBR GRADE 2, MEASURING 0.6-CM - INTERMEDIATE NUCLEAR GRADE, DUCTAL CARCINOMA IN SITU, SOLID AND CRIBRIFORM TYPES - SURGICAL RESECTION MARGINS NEGATIVE FOR TUMOR - BIOPSY SITE CHANGES WITH FIBROSIS - FIBROADENOMA AND SCLEROSING ADENOSIS - SEE SYNOPTIC REPORT AND SEE NOTE NOTE: Left axillary sentinel lymph node #2 touch preparation is negative. Therefore, the false- negativity is due to sampling error. The morphology of metastatic tumor is similar to the larger grade 3 tumor (see below). In the left mastectomy specimen, 2 nodules are grossly identified, larger nodule located in U0Q measuring 1.6 and is. of grade 3; and a smaller nodule, located in posterior UiQ, measuring 0.5-cm and is of grade 1. Breast biomarkers on both nodules are pending.. In the right mastectomy specimen, 4 nodules are grossly identified, one is fibroadenoma, one is sclerosing adenosis and the other two are separate foci of invasive ductal carcinoma. The largest invasive tumor measures 1.1-cm and it. is of grade 3. Breast biomarkers are as follows, ER negative, PR negative and HER-2/neu equivocai (2+, FISH pending). The smaller nodule measures 0.6-cm and it is of grade 2. The breast biomarkers are as follows ER  positive, PR positive and HER-2/neu equivocal (2+, FISH pending). Also, the morphology of grade 3 tumors (right and left) is different. It seems that there are 4 different primary tumors,. 2 in each breast. SYNOPTIC REPORT - BREAST
+
+--- Page 3 ---
+Specimens Involved Specimens:  B: SENTINEL LYMPH NODE #2 LEFT AXILLA C: LEFT BREAST Specimen Type:  Mastectomy Needle Localization: No Laterality: Left Invasive Tumor: Present Multifocality: Yes WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Tumor size. 1.6cm Tumor Site: Upper outer quadrant Upper inner quadrant Margins:  Negative Tubular Score: 3 Nuclear Grade: 2 Mitotic Score: 3 Modified Scarff Bloom Richardson Grade: 3 Necrosis: Present Vascular/Lymphatic Invasion: None identified Lobular neoplasia: None Lymph nodes: Sentinel lymph node only Lymph node status: Positive 1 / 2 Micrometastases: Yes DCIS present Margins uninvolved by DCIS DCIS Quantity:Estimate 5% DCIS Type: Solid DCIS Location:Associated with invasive tumor. Nuclear grade: Intermediate Necrosis: Present ER/PR/HER2 Results Performed on Case: see note Pathological staging (pTN): pT 1c N 1mic  SYNOPTIC REPORT - BREASTE Specimens Involved Specimens: D: SENTINEL LYMPH NODE #1 RIGHT AXILLA E: RIGHT BREAST Specimen Type: Mastectomy Needle Localization: No Laterality: Right Invasive Tumor: Present Multifocality: Yes WHO CLASSIFICATION  Invasive ductal carcinoma, NOS 8500/3 Tumor size: 1.1cm Margins: Negative Tubular Score: 3 Nuclear Grade: 3 Mitotic Score: 2  Modified Scarff Bloom Richardson Grade:. 3 Necrosis: Present Vascular/Lymphatic Invasion: None identified Lobular neoplasia: None Lymph nodes: Sentinel lymph node only Lymph node status Negative 0/1 DCIS present Margins uninvolved by DCIS DCIS Quantity: Estimate 2% DCIS Type: Solid Cribriform DCIS Location:Associated with invasive tumor.
+
+--- Page 4 ---
+Nuclear grade: Intermediate Necrosis: Absent ER/PR/HER2 Results Performed on Case:. see note Pathological staging (pTN): pT 1c N 0 SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimens Involved Specimens: E: RIGHT BREAST Specimen: Surgical Excision Block Number: E5, larger tumor ER: Negative Allred Score: 0 = Proportion Score 0 + Intensity Score 0 PR: Negative Allred Score: 0 = Proportion Score 0 + Intensity Score 0 COMMENT: The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring range from 0 to 8. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2. METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Immunohistochemistry was berformed using the mouse anti-human ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) provided by Dako ) tollowing the manufacturer s instructions. This assay was not modified Interpretation of the ER/PR immunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal review of staining performance. SYNOPTIC REPORT - BREAST HER-2 RESULTS Specimens Involved Specimens: E: RIGHT BREAST Specimen: Surgical Excision Block Number: E5 larger tumor Interpretation: EQUIVOCAL Intensity: 2+ % Tumor Staining: 10% Fish Ordered: Yes , on Date METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Her2 analysis was performed using the FDA approved Dako HercepTest (TM) test kit (Dako, Carpenteria, CA) using rabbit anti- human HER2. This assay was not modified. External kit-slides provided by the manufacturer (cell tines with high, low and negative HER2 protein expression) and in-house known HER2 amplified control tissue were evaluated along with the test tissue. Adequate, well preserved, clear-cut invasive carcinoma was identified for HER2 evaluation. Interpretation of the HER2 immunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal review of staining performance. This assay has been validated according to the 2007 joint recommendations and guidelines from ASCO and CAP and from the NCCN HER2 testing in Breast Cancer Task Force. The Pathoiogy Department takes full responsibility for this test's performance. SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimens Involved Specimens: . E: RIGHT BREAST Specimen: Surgical Excision Block Number: E13 smaller tumor ER: Positive Allred Score: 8 = Proportion Score 5 + Intensity Score 3 PR: Positive Allred Score: 8 = Proportion Score 5 + Intensity Score 3 COMMENT:
+
+--- Page 5 ---
+The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate. intensity of staining. 3 = strong intensity of staining), with a scoring range from 0 to 8. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2 METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Immunohistochemistrv was nerfnrmed using the mouse anti-human ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) provided by Dake. ) following the manufacturer s instructions. This assay was not modified. Interpretation of the ER/PR immunohistochemical stain is guided by published results in the medical literature,  information provided by the reagent manufacturer and by internal review of staining performance. SYNOPTIC REPORT - BREAST HER-2 RESULTS Specimens Involved Specimens: E: RIGHT BREAST Specimen: Surgical Excision Block Number: E13 larger tumor Interpretation: EQUIvOCAL Intensity: 2+ % Tumor Staining: 50% Fish Ordered: Yes, on Date. METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and nn Innner than 24 hours. Her2 analysis was performed using the FDA approved Dako HercepTest (TM) test kit using rabbit anti- human HER2. This assay was not modified. External kit-slides provided by the manutacturer (cell lines with high, low and negative HER2 protein expression) and in-house known HER2 amplified control tissue were evaluated along. with the test tissue. Adequate, well preserved, clear-cut invasive carcinoma was identified for HER2 evaluation. Interpretation of the HER2 immunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal review of staining performance. This assay has been validated according to the 2007 joint recommendations and guidelines from ASCO and CAP and from the NCCN HER2 testing in Breast Cancer Task Force. The Pathology Department takes full responsibility for this test's performance. CLINICAL HISTORY: Bilateral invasive breast carcinoma PRE-OPERATIVE DIAGNOSIS: Same INTRAOPERATIVE CONSULTATION DIAGNOSIS: TPD, Sentinel lymph node #1, right axilla: negative for carcinoma Diagnosis called at : .m. by Dr ADDENDUM:  Results for touch prep on specimen D was incorrectly designated in the Intraoperative Consultation Diagnosis above. as "TPC". Correct information is as follows:. SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimens Involved Specimens: C: LEFT BREAST Specimen: Surgical Excision  Block Number: C4 larger tumor ER: Negative Allred Score: 0 = Proportion Score 0 + Intensity Score 0 PR: Negative Allred Score: 0 = Proportion Score 0 + Intensity Score 0 COMMENT: The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of ceils staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring range from 0 to 8. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2
+
+--- Page 6 ---
+METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Immunohistochemistry was performed using the mouse anti-human ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) provided by Dako  Tollowing the manufacturer s instructions. This assay was not modified.. Interpretation of the ER/PR immunonistouemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal review of staining performance.. SYNOPTIC REPORT - BREAST HER-2 RESULTS Specimens Involved Specimens: C: LEFT BREAST Specimen: Surgical Excision Block Number: C4 larger tumor Interpretation: NEGATIVE Intensity: 1+ % Tumor Staining: 5% Fish Ordered: No METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Her2 analysis. was performed using the FDA approved Dako HercepTest (TM) test kit. using rabbit anti- human HER2. This assay was not modified. External kit-slides provided by the manutacturer (cell lines with high, low and negative HER2 protein expression) and in-house known HER2 amplified control tissue were evaluated along with the test tissue. Adequate, well preserved, clear-cut invasive carcinoma was identified for HER2 evaluation. Interpretation of the HER2 immunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal review of staining performance.. This assay has been validated according to the 2007 joint recommendations and guidelines from ASCO and CAP and from the NCCN HER2 testing in Breast Cancer Task Force. The Pathology Department takes full responsibility for this test's performance. SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimens Involved Specimens: C: LEFT BREAST Specimen: Surgical Excision Block Number: C14 smaller tumor ER: Positive Allred Score: 8 = Proportion Score 5 + Intensity Score 3. PR: Positive Allred Score: 8 = Proportion Score 5 + Intensity Score 3. COMMENT: The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5'= >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring range from 0 to 8.. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2. METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours.. Immunohistochemistrv was nerfnrmed sing the mouse anti-human ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) provided by Dako ! following the manufacturer s instructions. This assay was not modified.. Interpretation of the ER/PR immunohistochemical stain is guided by published results in the medical literature,. information provided by the reagent manufacturer and by internal review of staining performance.. SYNOPTIC REPORT - BREAST HER-2 RESULTS Specimens Involved Specimens:  C: LEFT BREAST Specimen: Surgical Excision Block Number: C14 smaller tumor Interpretation: EQUIVOCAL Intensity: 2+ % Tumor Staining: 10% Fish Ordered: Yes , on Date.
+
+--- Page 7 ---
+METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Her2 analysis was performed using the FDA approved Dako HercepTest (TM) test kit (Dako, Carpenteria, CA) using rabbit anti-. human HER2. This assay was not modified. External kit-slides provided by the manufacturer (cell lines with high, low and negative HER2 protein expression) and in-house known HER2 amplified control tissue were evaluated along. with the test tissue. Adequate, well preserved, clear-cut invasive carcinoma was identified for HER2 evaluation. Interpretation of the HER2 immunohistochemical stain is guided by published results in the medical literature,.  information provided by the reagent manufacturer and by internal review of staining performance. This assay has been validated according to the 2007 joint recommendations and guidelines from ASCO and CAP and from the NCCN HER2 testing in Breast Cancer Task Force. The Pathology Department takes full responsibility. for this test's performance. PathVysion HER-2 DNA Probe Kit Case No Analytical Interpretation of Results: HER-2 NOT AMPLIFIED Clinical Interpretation of results Amplification of the HER-2 gene was evaluated with interphase fluorescence in-situ hybridization (FISH) on formalin-fixed paraffin embedded tissue sections using a chromosome. 17 centromeric probe and a HER-2 probe that spans the entire HER-2 gene in the by Dr. A majority of tumors cells displayed 2 chromosome 17 signals and 2 HER-2 signals, with a HER-2/CEP 17 Ratio </=2.0, consistent with no amplification of the HER2/neu gene. Block used E5 Source of case: Tissue fixation formalin-fixed tissueOutside Case No:NA Tissue source breast Results interpreted: yes. HER2/CEP17 ratio: 1.03 This ratio is derived by dividing the total number of LSI HER-2/neu signals by the total number of CEP17 signals in at least 20 interphase nuclei with nonoverlapping nuclei in the neoplastic  mammary epithelial cells. Cells with no signals or with signals of only one color are disregarded. Method of ratio enumeration: manual count Limitations The Vysis PathVysion Kit is not intended for use to screen for or diagnose breast cancer. It is intended to be used as an adjunct to other prognostic factors currently used to predict disease-free. and overall survival in stage Il, node-positive breast cancer patients. In making decisions regarding adjuvant CAF treatment, all other available clinical information should also be taken into consideration, such as tumor size, number of involved lymph nodes, and steroid receptor status. No treatment decision for stage II, node-positive breast cancer patients should be based on HER-2/neu. gene amplification status alone Overview of this test FDA APPROVED REAGENT PathVysion HER-2 DNA Probe Kit is FDA approved for selection of patients for whom Herceotin theraov is being considered. These tests were performed in the under the direction of Dr. The results of these studies should always be interpreted in the context of the clinical, morphological, and immunophenotypic diagnosis. PathVysion HER-2 DNA Probe Kit Case No Analytical Interpretation of Results: HER-2 NOT AMPLIFIED Clinical Interpretation of results Amplification of the HER-2 gene was evaluated with interphase fluorescence in-situ hybridization (FiSH) on formalin-fixed paraffin embedded tissue sections using a chromosome 17 centromeric probe and a HER-2 probe that spans the entire HER-2 gene in the  by Dr. A majority of tumors cells displayed 2 chromosome 17 signals and 2 HER-2 signals, with a HER-2/CEP 17 Ratio </=2.0, consistent with no amplification of the HER2/neu gene. Block used E13 Source of case: Tissue fixation formalin-fixed tissueOutside Case No: NA Tissue source breast Results interpreted: yes. HER2/CEP17 ratio: 0.91 This ratio is derived by dividing the total number of LSI HER-2/neu signals by the total number of CEP17 signals in at least 20 interphase nuclei with nonoverlapping nuclei in the neoplastic mammary epithelial cells. Cells with no signals or with signals of only one color are disregarded. Method of ratio enumeration: manual count. Limitations The Vysis PathVysion Kit is not intended for use to screen for or diagnose breast cancer. It is intended to be used as an adjunct to other prognostic factors currently used to predict disease-free. and overall survival in stage ll, node-positive breast cancer patients. In making decisions regarding. adjuvant CAF treatment, all other available clinical information should also be taken into consideration, such as tumor size, number of involved lymph nodes, and steroid receptor status. No treatment decision for stage Il, node-positive breast cancer patients should be based on HER-2/neu. gene amplification status alone.
+
+--- Page 8 ---
+Overview of this test FDA APPROVED REAGENT PathVysion HER-2 DNA Probe Kit is FDA approved for selection of patients for whom Herceptin therapy is being considered. These tests were performed in the under the direction of Dr. The results of these studies should always be interpreted in the context of the clinical, morphological, and immunophenotypic diagnosis..
+
+--- Page 9 ---
+Case No Analytical Interpretation of Results: HER-2 NOT AMPLIFIED Clinical Interpretation of results Amplification of the HER-2 gene was evaluated with interphase fluorescence in-situ hybridization (FISH) on formalin-fixed paraffin embedded tissue sections using a chromosome 17 centromeric probe and a HER-2 probe that spans the entire HER-2 gene in the by Dr. A majority of tumors cells displayed 2 chromosome 17 signals and 2 HER-2 signals, with a HER-2/CEP 17 Ratio </=2.0, consistent with no amplification of the HER2/neu gene.. Block used C14 Source of case: Tissue fixation formalin-fixed tissueOutside Case No: NA Tissue source breast  Results interpreted: yes. HER2/CEP17 ratio: 0.94 This ratio is derived by dividing the total number of LSI HER-2/neu signals by the total number of CEP17 signals in at least 20 interphase nuclei with nonoverlapping nuclei in the neoplastic. mammary epithelial cells. Cells with no signals or with signals of only one color are disregarded.. Method of ratio enumeration: manual count Limitations The Vysis PathVysion Kit is not intended for use to screen for or diagnose breast cancer. It is intended to be used as an adjunct to other prognostic factors currently used to predict disease-free.  and overall survival in stage Il, node-positive breast cancer patients. In making decisions regarding.  adjuvant CAF treatment, all other available clinical information should also be taken into. consideration, such as tumor size, number of involved lymph nodes, and steroid receptor status. No. treatment decision for stage il, node-positive breast cancer patients should be based on HER-2/neu gene amplification status alone Overview of this test FDA APPROVED REAGENT  PathVysion HER-2 DNA Probe Kit is FDA approved for selection of patients for whom Herceptin therapy is being considered. These tests were performed in the under the direction of Dr. The resuits of these studies should always be interpreted in the context of the. clinical, morphological, and immunophenotypic diagnosis. Gross Dictation:  Microscopic/Diagnostic Dictation: Final Review: Pathologist, Final Review: Pathologist, Final: Pathologist,. Addendum Reviev.. r awviuyis. Addendum Final: Pathologist, Addendum: Pathologist, Addendum Final: M.D., Patnoiogist, Addendum: Pathologist, Addendum Final: Pathologist, Addendum: Pathologist, Addendum Final: Pathologist
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diff --git a/output/text/1273bc57-9b85-42e8-8760-03a4c3da1151.txt b/output/text/1273bc57-9b85-42e8-8760-03a4c3da1151.txt
new file mode 100644
index 0000000000000000000000000000000000000000..29b64648156b6b5947cd8494d57da5b2b36de422
--- /dev/null
+++ b/output/text/1273bc57-9b85-42e8-8760-03a4c3da1151.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID: 3AD4AA3C-5F68-43D1-B578-07AB574D4DE3 TCgA-LL-A740-01A-Pr Redacted RUN DATE: PAGE 1 RUN TIME: RUN USER: PATIENT: ACCr #: LOC: AGE/SX: ROOM: REG DR: DOB: BED: STATUS: SPEC #: RECD: STATUS : COLL : TIME IN FORMALIN: hrs. COLD ISCHEMA TIME: mins. CLINICAL INFORMATION: Pre-Op Diagnosis: Right breast mass Remarks: Specimen(s): A. Right breast needle localized lumpectomy for immediate gross evaluation IcD :0 3 B. Sentinel lymph node Carma, irystetigdeft45 8sco|3 c so.l9 RIGHT BREAST (EXCISION WITH NEEDLE LOCALIZATION) : A. HJ8/113 INVASIVE DUCTAL CARCINOMA,: 1.7 CM GREATEST DIMENSION MARGINS APPEAR UNINVOLVED SEE COMMENT FOR SYNOPTIC REPORTS B. SENTINEL LYMPH NODE. RIGHT AXILLA (BIOPSY):  NO METASTASIS IN ONE LYMPH NODE COMMENT (S) SURGICAL PATHOLOGY CANCER CASE SUMMARY - CAP APPROVED Procedure: Excision with wire-guided localization Lymph Node Sampling: Sentinel lymph node(s) Specimen Laterality: Right Histologic Type: Invasive ductal carcinoma. Tumor Size: Greatest dimension of largest focus of invasion >1 mm: 17 mm Histologic Grade (Nottingham): Glandular: Score 2 Nuclear Pleomorphism: Score 3 Mitotic Rate: Score 1 Overall Grade: Grade 2 Tumor Focality: Single focus of invasive carcinoma Ductal Carcinoma In Situ (Dcis): (Dcis is present) negative for extensive intraductal component (EIC) Architectural Patterns: Comedo. Cribriform Nuclear Grade: Grade III (high) Necrosis: Present. central (expansive "comedo" necrosis) Margins: Invasive Carcinoma: Margins uninvolved by invasive ** CONTINUED ON NEXT PAGE **
+
+--- Page 2 ---
+RUN DATE: PAGE 2  RUN TIME: RUN USER: SPEC #: PATIENT: (Continued) COmmEnt(S) (Continued) carcinoma Distance from closest margin: 2 mm DCIs: Margins uninvolved by DCIS Distance from closest margin: 5 mm Lymph Nodes: Number of sentinel lymph nodes examined: 1. Total number of lymph nodes examined (sentinel and nonsentinel): 1 Number of lymph nodes with metastases:. Method of Evaluation of Sentinel Lymph Nodes: H&E. multiple levels. immunohistochemistry. Lymph-Vascular Invasion: Not identified Pathologic Staging: Primary Tumor: pT1c Regional Lymph Nodes: Modifier: (sn) Category: pNo(i-) Distant Metastasis: Not applicable Ancillary Studies: Performad ol. ER: Nagative (<1% of tumor cells with nuclear positivity) PR: Negative (<1% of tumor cells with nuclear positivity) HER2 Immunoperoxidase Studies: Equivocal (Score 2+) In Situ Hybridization for HER2 (FIsH or CIsH): Not amplified (HER2 gene copy <4.0 or ratio <1.8) GROSS DESCRIPTION: This specimen is received in the fresh state from the operating room for immediate A. gross evaluation of the surgical margins and for specimen x-ray. Specimen x-ray is lesion. The specimen consists of a portion of breast tissue which measures 7.5 x 6 x 2 cm. A needle is situated in the spscimen..  The margins have not been differentially tagged Blue ink is applied to the margins. Sections reveal a firm. tan tumor measuring 1.7 x 1.5 x 1.5 cm located 3 mm from the nearest surgical margin. A representative section of the is removed by aseptic technique and submitted for tumor banking..  The following tumor sections are submitted: 1-5 tumor sectioned and totally submitted. blue ink on margins. representative breast and margins B. This specimen in the frash state is a soft, tan lymph node measuring 12 x 10 x 7 mm. sectioned and totally submitted as block B1. ** CONTINUED ON NEXT PAGE **
+
+--- Page 3 ---
+RUN DATE: RUN TIME: PAGE 3 RUN USER: SPEC #: PATIENT: (Continued) MICROSCOPIC DESCRIPTION: A. Sections of the breast tumor demonstrate invasive ductal carcinoma with focal apocrine features, combined histologic grade 2 of 3.  DcIs is present axhibiting comedo and cribriform growth patterns with nacrosis and a high nuclear grade. The ncis does not. appear extensive. Nearby breast tissue uninvolved by tumor demonstrates at least one radial sclerosing lesion and foci of ductal epithelial hyperplasia, focally atypical. The inked margins appear uninvolved. See the comment for a synoptic report. INTRAOPERATIVE CONSULTATION: A IMMEDIATE GROSS EVALUATION RIGHT BREAST MASS: RADIOGRAPHIC TARGET LESION PRESENT BY SPECIMEN X-RAY SURGICAL MARGINS APPARENTLY FREE OF TUMOR, 2 MM FROM TUMOR PHOTO IXXUMENTATION Image Image Signed (signature on file). ** END OF REPORT ** p 8||13 oancy DOES
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diff --git a/output/text/128769a8-c9d4-4a9d-a470-eb56951588d9.txt b/output/text/128769a8-c9d4-4a9d-a470-eb56951588d9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2e5920c19582b7d53390582e68289307d5c77f00
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+
+--- Page 1 ---
+Tumor: Normal: Slide: Microscopic Description: Sections demonstrate a moderately hypercellular glial neoplasm that diffusely infiltrates both gray and white matter. The tumor is composed primarily of cells resembling. fibrillary astrocytes and to a lesser degree, gemistocytic astrocytes. In the much larger specimen 2, gemistocytic astrocytes predominant, whereas fibrillary astrocytes predominate in specimen 1. There is prominent prineuronal satellitosis. Atypia is mild to moderate. Whereas there are generally only rare mitoses, up to three mitoses are seen in 10 high power fields. There is no microvascular proliferation or necrosis. Addendum Discussion: The calculated MIB-1 labeling index ranges up to 25.5% in the most proliferative regions of tumor. Addendum Diagnosis: Frontal Brain Tumor, Anaplastic Astrocytoma, Gemistocytic (Who Grade III) MIB-1 Labeling Index= 25.2%
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diff --git a/output/text/1294d03a-d242-4869-bda1-49f304d9d7b2.txt b/output/text/1294d03a-d242-4869-bda1-49f304d9d7b2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8dc0bd5ccb5d2b7467708edbdabf0f20e8b4ae16
--- /dev/null
+++ b/output/text/1294d03a-d242-4869-bda1-49f304d9d7b2.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+/cs-0-3 Site> bresot, Nis c50.9 UUID:929AB6C9-58B0-4E37-A2B4-9FC1F9099437 IRB APPROVED TCGA-C8-A26V-01A-PR Redacted MulTI-media Systems, Inc.  Form Revised cal Case Report (For Collection of Cancerous Tissue) Informed Consent I personally informed this patient that a specimen(s) would be collected to be used for research. purposes. I reviewed the RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at. our institution. ) Signature Date Name of Physician or Study Coordinator Clinical Information ESSKSWOASNRGENERALINFORMATIONIAALA Race Temperature Height Marital Status Date of Birth (mm/dd/wwv)  Single Married Blood Pressure Heart Rate Weight  Divorced  Widow Gender  Male Female TSHISTORYOFPRESENTILLNESSA:  npple Jefaitn Chief Complaints: pain in te eost- Symptoms: Clinical Findings: j lumpin the ampit nipple Performance Scaie (Karnofsky Score):   60-70 Symptomatic, in bed less than 50% of day  100 Asymptomatic 80-90 Symptomatic but Fulily Ambulatory  20-30 Bed Ridden  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden TEMCURRENTMEDICATIONS Date (mm/dd/yyy) Dose Route Freguency Drug To / To To To To
+
+--- Page 2 ---
+PAST MEDICAL HISTORY. Diagnosis/Disease/Disorder/Injury  Diagnosis Date Treatment Status Menopausal Status Date of First Menses. # of Pregnancies  Pre-menopausal 1 3 yeanl! 0 2 Peri-Menopausal Date of Last Menses. # of Live Births  Post-menopausal o 2 Birth Control:  Condom Oral Contraceptive  lUD  Hormone Replacement  Other: Therapy: SOCIALHISTORYA Occupation: Environmental Hazards: Smoking History. Current Status TYPE  Packs/day Duration When Quit YES NO (yrs)  (yr) Alcohol Consumption Current Status TYPE  Drinks/day Duration When Quit  YES RNO (yrs) (yr) Drug Use Current Status TypE Frequency Duration When Quit  yES NO (yrs)  (yr) EFAMILYMEDICAEHISTORYAN  Relative Diagnosis Age of Diagnosis LABDATAO O Test Result Date Test Resuit Date HIV CEA Negative  Positive:  Negative  Positive: Hep B r CA 15-3   Negative  Positive: Negative  Positive: / CA 19-9  Negative  Positive: Hep C Negative  Positive: PSA  Negative  Positive: AFP   Negative  Positive: Other: Other:  Negative  Positive:  Negative Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+:.*SGDIAGNOSTIC STUDIES Results Date Study Ultrasound X-Ray CT Endoscopy. MRI Baeas+ cane? Biopsy  SEKASSNCLINICALDIAGNOSISS M Preoperative Clinical Diagnosis. Location of Suspected Distant Metastasis Location of Suspected Involved Lymph Nodes. Date of Diagnosis Clinical Staging N2MO Stage: T A Tz I Treatment Information. WSSURGICAETREATMENT Date of Procedure  Procedure M aste itonuy Mo dsfied Padi cal. Primary Tumor  Size Detailed Location Organ Cutoa! sR liYn 5 x Zxz cm i Ri q5t tumR aF The tsreas!! Extension of Tumor Lymph Nodes # of Lymph Nodes  Location of Lymph Nodes. Description Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Size Detailed Location Organ Surgica! Staging Stage: T z m o NEOADJUVENTTHERAPY(ChemoRadiation ImmunoHormonal or Molecular Date (mm/dd/yyyy) Route Frequency Dose Drug/Treatment To To To 1 To 1 1 1 To 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by: Date: Preserved by: Dat **SPECIMENTYPE (#of samples provided*+  Frozen Paraffin Block  Blood/Serum/Plasma Slide  Diseased  Norma! Diseased Normal Diseased Normal Diseased Norma! 2 4 2 2f 7 Time to LN2 Time to Formalin  Time to LN2 12 min 23 min min  EPATHOLOGICAEDESCRIPTIONK Primary Tumor Organ Size Extension of Tumor Distance to NAT 5 Beeaet TeesscR 5x  ycm|cen72a/pRTion cm Lymph Nodes Location # Examined # Metastasized Distant Metastasis Organ.  Detailed Location Size Pathological Staging pT3 N2 MO Stage: II Notes: BReos7 noqes 8(jos'live 5 Neg>7i've 3 ) 2 Cax$s7Ks nxl-(Mj,M2) ih x1j7Roqeh 4
+
+--- Page 5 ---
+Microscopic Description .Hitoogic Pattern + Structural Pattern + Cell Distribution  Streaming  Diffuse  Mosaic Storiform Necrosis  Fibrosis  Lymphocytic Infiltration Palisading Cystic Degeneration Vascular Invasion Bleeding Clusterized Alveolar Formation  Myxoid Change  Psammoma/Calcification Indian File . .CelluarDifferentiationaect  Sarcomatous +-Lymphomatous +- Adenomatous Squamous a Round Cell Large Cell  Squamoid Cell Glandular cell Small Cell Cell Stratification Fibroblast Spindle Cell Osteoblast  RS Cell/RS Like  Keratin  Secretion  Lipoblast Inflam. Cell  Desmosome Intracyt. Vacuole Myoblast Plasma Cell Peari  Gland formation Well Moderate  Poor Cellular Differentiation: aw uclearAppearance 0 1 II III Nuclear Atypia: a  Aniso Nucleosis  Hyperchromatism  Nucleolar Prominent  Multinucleated Giant Cell  Mitotic Activity Nuclear Grade: Date Value Marker Result ER  Negative Positive PR  Negative  Positive Negative  Positive  Her-2/neu  B-Cell Marker  Negative  Positive  Negative  Positive T-Cell Marker Other: Negative  Positive Negative  Positive Other: Final Pathology Report FRF/tea Tirg ducTal carcinoma: Histological Diagnosis: Grade:T Riegrantit teg Moelerate li. pRexst noHos =8 ( postiee 5j Ncgrti're 3) Comments: (Mp,MZ p0isTi*Q Date  Pathologist  Principal Investigator 5
+
+--- Page 6 ---
+CONsOLIDaTeD DIagnOstIc pathOLOgy fORm* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION Diffuse + STRUCTURAL PATTERN Mosaic I Streaming Necrosis XX  Storiform Lymphocytic Infiltration  Fibrosis Vascular Invasion Palisading Clusterized X Cystic Degeneration Aiveolar Formation Bleeding Indian File Myxoid Change Psammoma/Calcification 2. Cellular features. Sgua mous + Adenomatous + . Sareomatous Sguamoid Cell Glandular cell + Lymphomatou Round Cell Spindle Cell Cell Stratification Large Cell Fibroblast Keratin Small Ceu  Secretion Desmosome Osteoblast  RS CeIVRS Like Intracyt. Yacuole 47 Lipoblast Inflam. Cell Pear! Gland formation Myoblast Piasma Cell Otherwise Specified: D, 707 br70% >3Zo% D470Z Meekess 2.Cellular Differentiation: Well  Moderasely Poor X Nuclear Atypia: Nuckar Appearance Aniso Nucleosis Hyperchromatism Nucleolar Prominent Multinucleated Giant Celld Mitotic Activity Nuckear Grade Histological Diagnosis: Idpltsg fsng Ssetal CaLci n ems, Nt 6-2 : Cakciroxa Metastas/zed tolO. M,u. Comments:  Date Director, Research Pathology : PATHOLOGIST STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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diff --git a/output/text/129595cb-d662-49df-b0a0-edf488cf4c8d.txt b/output/text/129595cb-d662-49df-b0a0-edf488cf4c8d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d43adeb8146d83901749e5cb7443a9722df8599f
--- /dev/null
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@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+UUID:D531397C-85E3-4C46-BB9C-0780CBFE25D6 TCGA-DK-A2HX-01A-PR Redacted sL PAThOLOgy REPORt Patient Name: Med. Rec. #: Accession #: Date of Procedure: DOB: Location: Gender: Date of Receipt: F Service: Urology Ref. Physician: Date of Report: Patient Address: Account #: Billing Type: INPATIENT Ref. Source: Additional Copy to: Clinical Diagnosis & History: History of muscle invasive HGTCC with micropapillary, signet ring, mucinous features. Specimens Submitted: 1: Small intestine, "implants"; biopsy ics-s-3 2: Lymph nodes, right common iliac; excision cavmma, usoHelisl, Nvs 3: Lymph nodes, right pelvic; excision. 4: Lymph nodes, presacral;, excision 81a0/3 5: Lymph node, Marcille's; excision 6: Lymph nodes, left pelvic; excision. StL:b1ddv,wtl, NOs 7: Lymph nodes, left common iliac; excision Ci7.9 8: Bladder, urethra and anterior vaginal wall; radical cystectomy 9: Stent, left ureter; removal ls 6fs3f DIAGNOSIS: Small intestine, "implants"; biopsy: -Gastrointestinal stromal tumor, 0.9 cm. -Immunohistochemical stains show that the tumor is diffusely positive for CD117, and negative for S100, desmin and HHF35. 2.  Lymph nodes, right common iliac; excision: Lymph Node Dissection:  Benign lymph nodes Number of lymph nodes examined: 1 3.Lymph nodes, right pelvic; excision: Lymph Node Dissection:  Metastatic urothelial carcinoma Number of lymph nodes examined: 17 Number of lymph nodes with metastatic disease: 2 Size of the largest lymph node involved by tumor: 1.2cm. Size of the largest metastatic focus : 0.2 cm. Extranodal extension is not identified 4. Lymph nodes, presacral; excision: Lymph Node Dissection:  Metastatic urothelial carcinoma Number of lymph nodes examined: 6. Number of lymph nodes with metastatic disease: 1 Size of the largest lymph node involved by tumor: 0.15cm. Size of the largest metastatic focus : 0.005 cm. 5. Lymph node, Marcille's; excision: Page 1 of 6
+
+--- Page 2 ---
+SUrGICAL PATHOLOgy REPORt Lymph Node Dissection: Benign lymph nodes Number of lymph nodes examined: 1 6. Lymph nodes, left pelvic; excision: Lymph Node Dissection:. Metastatic urothelial carcinoma Number of lymph nodes examined: 10 Number of lymph nodes with metastatic disease: 1 Size of the largest lymph node involved by tumor: 1.3cm. Size of the largest metastatic focus : 0.18 cm. Extranodal extension is not identified. 7. Lymph nodes, left common illac; excision: Lymph Node Dissection:  Benign fibroadipose tissue. 8. Bladder, urethra and anterior vaginal wall; radical cystectomy: Tumor Type: Urothelial carcinoma with mixed histologic features, including: micropapillary, diffuse and signet ring cell some treatment related changes are present Histologic Grade: High grade Pattern of growth of the Non-Invasive component:  In situ component not identified Pattern of growth of the Invasive component: Diffuse Tumor Multicentricity: Not identified the bladder wall is diffusely involved by tumor Bladder Local Invasion:. Perivesical soft tissues Extravesical Tumor Extension: Ureters uninvolved Urethra uninvolved Tumor involves soft tissue around both ureters. Vascular Invasion:  Identified Perineural Invasion: Identified Surgical Margins: Tumor present at right ureteral margin Tumor present at left ureteral margin Non-Neoplastic Mucosa: Exhibiting ulceration. Exhibiting foreign body reaction. Exhibiting proliferative cystitis (Brunn's nests, cystitis cystica, cystitis glandularis)  Page 2 of 6
+
+--- Page 3 ---
+SURGICAL PATHOLOGY REPORT Female Genital Organs:  The vagina shows no pathologic changes. Perivesical Lymph Nodes: Not identified The Pathologic Stage is (AJCC 2002): pT3 (Invasion of perivesicle sont tissue) 9. Stent, left ureter; removal:. -Stent, gross examination only.. 1 ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL). AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Special Studies: Result Speci al Stain CD11 Comment DES 7 CMA(HHF35) S100 NEG CONT IMM RECUT Gross Description: 1. The specimen is received fresh, iabeled "small bowel implant". It consists of one piece of tan red soft tissue measuring 0.9 x 0.9 x 0.8 cm. The specimen is bisected and submitted entirely for frozen section.. Summary of Sections: FSC- frozen section control 2.) The specimen is received fresh, labeled "right common iliac lymph nodes" and consists of one pink tan firm lymph node measuring 0.6 x 0.4 x 0.2 cm.The specimen is entirely submitted.. Summary of sections: LN - Iymph nodes 3.) The specimen is received fresh, labeled "right pelvic lymph nodes" and consists of multiple pink tan firm lymph nodes ranging from 0.2 cm to 1.2 cm in greatest dimension. All identified lymph nodes are submitted. Summary of sections: LN - lymph nodes 4.) The specimen is received fresh, labeled "presacral lymph nodes" and consists of multiple pink tan firm lymph nodes ranging from 0.1 cm to 0.4 cm in greatest dimension. All identified lymph nodes are submitted.  Page 3 of 6
+
+--- Page 4 ---
+SURGICAL PATHOLOGY REPORT Summary of sections:  LN - lymph nodes 5.) The specimen is received fresh, labeled "lymph node from Marcille" and consists of one possible pink tan firm lymph node measuring 1.2 x 0.5 x 0.3 cm.The specimen is entirely submitted. Summary of sections: LN - tymph node 6.) The specimen is received fresh, labeled "left pelvic lymph nodes" and consists of multiple pink tan firm lymph nodes ranging from 0.3 cm to 1.8 cm in greatest dimension. All identified lymph nodes are submitted. Summary of sections: LN - lymph nodes BLN - bisected lymph nodes 7.) The specimen is received fresh, labeled "left common iliac lymph nodes" and consists of one pink tan firm lymph node  measuring 0.5 x 0.4 x 0.2 cm.The specimen is entirely submitted. Summary of sections: LN - lymph nodes 8. The specimen is received fresh, labeled "bladder, urethra and anterior vaginal wall". it consist of a bladder and anterior vaginal wall with bilatera ureters measuring 13cm from superior to inferior, 10 cm laterally and 4cm from anterior to posterior. The bladder measures 12 x10 x 4 cm. The portion of vaginal cuff measures 2x 1.5 x 0.6 cm. The distal urethra and the vaginal cuff margin are shaved and submitted. The ureteric stumps measure 0.6 cm in lenght and 0.2 cm in diamter. The specimen is inked green on the right side and blue on the left side and the bladder is opened anteriorly to reveal an infiltrating firm lesion 5.5x 3.5 x 3.0 cm. The. Jesion is located in the left postero lateral wall and extends.to.the.dome.region. The distance from the left and the right ureteric. orifices are 0.4 cm and 2.8 cm respectively. On sectioning, the tumor extends to a depth of 3.0cm, and is approaching the. perivesical fat grossly. The remaining bladder mucosa shows edematous mucosa. Discrete perivesical lymph nodes are not identified. Tissue is submitted for TPs.  Representative sections are submitted. Summary of sections: UTHM - distal urethra  RUM - right ureter margin LUM - left ureter margin L - lesion  RUO - right ureteric orifice LUO - left ureteric orifice LP- left posterior wall LA - left anterior wall  RP- right posterior wall  RA - right anterior wall  TRI - trigone DOME - dome F - perivesical fat DVM - distal vaginal margin 9). The specimen is received fresh labeled, "Stent from left ureter" and consists of an elongated tubular blue stent measuring 25 x 0.3 x 0.3 cm. The specimen is photographed. Gross only. Page 4 of 6
+
+--- Page 5 ---
+SURGICAL PATHOLOGY REPORT Summary of Sections:. Part 1:  Small intestine, "implants"; biopsy  Block Sect. Site PCs 1 FSC 1 Part 2: Lymph nodes, right common iliac; excision. Block Sect. Site  PCs 1 LN 1 Part 3:Lymph nodes, right pelvic; excision. Block Sect. Site PCs 5 LN 5 Part 4: Lymph nodes, presacral; excision Block Sect. Site PCs 1 LN 1 Part 5: Lymph node, Marcille's; excision. Block Sect. Site PCs 1 LN 1 Part 6: Lymph nodes, left pelvic; excision Block Sect. Site PCs BLN 2 2 2 LN 2 Part 7: Lymph nodes, left common illac; excision. Block Sect. Site PCs 1 LN 1 Part 8:  Bladder, urethra and anterior vaginal wall; radical cystectomy Block Sect. Site PCs 1 DOME 1 1 DVM 1 1 1 6 L 6 1 LA 1 1 LP 1 1 LUM 1 1 LUO 1 1 RA 1 1 RP 1 RUM 1 1 RUO 1 1 TRI 1 1 UTHM 1 Part 9: Stent, left ureter; removal.  Page 5 of 6
+
+--- Page 6 ---
+SUrgICAl PaAThOLOgy REpORt Intraoperative Consultation:e 1. Frozen section diagnosis: Small bowel implants Spindle cell proliferation. Permanent diagnosis: See final. Page 6 of 6 END OF REPORT
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diff --git a/output/text/12a57008-3d42-401f-a10c-162b48748ec7.txt b/output/text/12a57008-3d42-401f-a10c-162b48748ec7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ffb373638e13dd99a1c7d6f1f992db0db1b2cdeb
--- /dev/null
+++ b/output/text/12a57008-3d42-401f-a10c-162b48748ec7.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+1c0-0-3 Carunomn, lobular, N0s 85a0|3 12/810 lw beurt, Nts Sire Code TSS: SPECIMENS: A. NEEDLE LOCALIZATION LEFT BREAST B. SENTINEL LYMPH NODE #1 RIGHT AXILLA C. SENTINEL LYMPH NODE #2 RIGHT AXILLA D. RIGHT BREAST E. ADDITIONAL ANTERIOR FLAP RIGHT BREAST UPPER OUTER QUADRANT SPECIMEN(S): A. NEEDLE LOCALIZATION LEFT BREAST B. SENTINEL LYMPH NODE #1 RIGHT AXILLA C. SENTINEL LYMPH NODE #2 RIGHT AXILLA D. RIGHT BREAST E. ADDITIONAL ANTERIOR FLAP RIGHT BREAST UPPER OUTER QUADRANT GROSS DESCRIPTION: A. NEEDLE LOCALIZATION LEFT BREAST Received fresh labeled with the patient's identification and "needle localization left breast' is an oriented. 18g, 6 x 3.5 x 2.4cm needle localized lumpectomy with radiograph. Ink code: anterior-yellow, posterior. black, superior-blue, inferior-orange, medial-green, lateral-red. Specimen is serially sectioned from medial to lateral into 12 slices revealing unremarkable breast parenchyma. Entirely submitted: A1: medial margin slice 1 A2-A3: slice 2 A4-A5: slice 3 A6-A7: slice 4 UUID:C04B3267-9833-44D6-8C3D-45D7F829C38C A8-A9: slice 5 TCGA-E2-A15L-01A-PR A10-A11: slice 6 Redacted A12-A13: slice 7 A14-A15: slice 8 A16-A17: slice 9 A18-A19: slice 10 A20-A21: slice 11 A22: lateral margin slice 12 B. SENTINEL LYMPH NODE #1 RIGHT AXILLA Received fresh is a tan pink lymph node 2.8 x 2.4 x 1cm. The specimen is sectioned and two touch. preps are taken. Toto B1-B2 C. SENTINEL LYMPH NODE #2 RIGHT AXILLA Received fresh are two tan pink lymph nodes 1.2 x 1 x 0.8cm and 0.6 x 0.4 x 0.4cm. Two touch preps are taken. C1: one lymph node C2: one lymph node D. RIGHT BREAST Received fresh labeled with the patient's identification and "right breast" is an 1129g, 29 x 24 x 5cm oriented (stitch in axilla) simple mastectomy with 23 x 9cm tan pink skin ellipse with 0.5 cm scar, 3.5cm. from the nipple in the UIQ, and 0.8cm flattened nipple. Ink code: anterior-superior-blue, anterior-inferior- orange, posterior-black. The specimen is serially sectioned from medial to lateral into 14 slices with. nipple in slice 10, revealing a 1.8 x 1.7 x 1.7cm tan white firm well circumscribed mass, 1.4cm from the deep margin in the UOQ of slices 11-12. Also seen is a 0.7 x 0.5 x 0.5cm previous biopsy site with surrounding fat necrosis, 2.4cm from the mass and corresponding to the scar on the skin surface in the. UC of slice 10. A portion of the specimen is submitted for tissue procurement. Representatively submitted: D1: nipple slice 10 D2: UIQ slice 5 D3: LIQ slice 7 D4: UIQ slice 9 D5: LIQ slice 9 D6-D7: biopsy site UC slice 10 D8: area next to mass UC slice 10 D9: deep margin UC slice 10 D10: LC slice 10 D11: next to biopsy site UOQ slice 11
+
+--- Page 2 ---
+D12: mass UOQ slice 11 D13: deep margin UOQ slice 11 D14: scar UOQ slice 11 D15: LOQ slice 11 D16: mass UOQ slice 12 D17: deep margin UOQ slice 12 D18: anterior margin UOQ slice 12 D19: LOQ slice 12 D20: UOQ slice 13 E. ADDITIONAL ANTERIOR FLAP RIGHT BREAST UPPER OUTER QUADRANT. Received fresh is an oriented (suture at final margin) 18g, 8.4 x 3.9 x 2cm fibrofatty tissue. Final margin is inked blue. Serial sectioning reveals no discrete lesions. Representatively submitted in E1-E2. DIAGNOSIS: A. BREAST, LEFT, NEEDLE LOCALIZATION EXCISION: - ATYPICAL LOBULAR HYPERPLASIA (ALH) AND PREVIOUS BIOPSY SITE CHANGES. B. SENTINEL LYMPH NODE 1, RIGHT AXILLA, BIOPSY:E - ONE LYMPH NODE. NO TUMOR SEEN (O/1) C. SENTINEL LYMPH NODE 2, RIGHT AXILLA, BIOPSY:E - TWO LYMPH NODES, NO TUMOR SEEN (0/2). NOTE: Cytokeratin AE1/3 stains were performed on B1 and C1 and are negative. D. BREAST,RIGHT, MASTECTOMY: - MULTIFOCAL INVASIVE LOBULAR CARCINOMA, SBR GRADE 2. - LARGEST TUMOR MEASURES 2.2 CM. - MARGINS, FREE OF TUMOR. - DUCTAL CARCINOMA IN SITU (DCIS), MICROPAPILLARY TYPE, NUCLEAR GRADE 2, WITH NECROSIS - LOBULAR CARCINOMA iN SITU (LCIS). - SKIN AND NIPPLE, NO TUMOR SEEN. NOTE: The tumor is present in the upper inner and upper outer quadrants with the largest focus of invasive carcinoma measuring 2.2 cm that is associated with previous biopsy site changes. In addition, a few small foci (the largest of the small foci is 0.3 cm) of invasive carcinoma are seen, with one focus associated with previous biopsy site changes. E. BREAST, RIGHT, ADDITIONAL ANTERIOR UPPER OUTER QUADRANT, EXCISION: - NO TUMOR SEEN. SYNOPTIC REPORT - BREAST Specimen Type: Mastectomy Needle Localization: No Laterality: Right Invasive Tumor.-- Present Multifocality: Yes WHO CLASSIFICATION  Invasive lobular carcinoma 8520/3 Tumor size:  2.2cm Margins: Negative Tubular Score: 3 Nuclear Grade: 2 Mitotic Score: 1 Modified Scarf Bloom Richardson Grade: 2 Necrosis: Absent Vascular/Lymphatic Invasion: None identified Lobular neoplasia: LCIS Lymph nodes: Sentinel lymph node
+
+--- Page 3 ---
+Lymph node status: Negative 0/3 DCIS present Margins uninvolved by DCIS DCIS Quantity: Estimate 10% DCIS Type: Micropapillarye DCIS Location: Associated with invasive tumor Nuclear grade: Intermediate Necrosis: Present ER/PR/HER2 Results ER: Positive PR: Positive HER2: Negative by FISH Performed on Case: Pathological staging (pTN): pT 2 N 0 Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition. CLINICAL HISTORY: Right invasive lobular carcinoma and left atypical lobular hyperplasia.. year-old post menopausal female noted a right breast mass  Mammogram performed showed 1.8 x 2cm mass in right breast, solid in nature on ultrasound. Repeat imaging also showed. left breast nodule at 9 o'clock. Biopsy of both lesions showed right invasive lobular carcinoma. Left breast atypical lobular hyperplasia. PRE-OPERATIVE DIAGNOSIS: Right invasive lobular carcinoma, left atypical lobular hyperplasia INTRAOPERATIVE CONSULTATION: TPB1-TPB2-TPC1-TPC2: SLN #1-#2 Right axilla-No definitive tumor cells identified. Diagnoses called to Dr at . (B) anc (C) by Dr. ADDENDUM: ONCOTYPE DX BREAST CANCER ASSAY RESULTS: Recurrence Score: 8 CLiNICAL EXPERIENCE: Patients with a recurrence score of: 8 in the clinical vatidation study had an average rate of Distant Recurrence at 10 years of 6% ER Score: 10.6Positive PR Score: 9 Positive Her2 Score: 9.3 Negative Interpretation: ER Negative <6.5 Positive >= 6.5 PR Negative < 5.5 Positive >= 5.5 Her2 Negative <10.7 Positive >=11.5 Equivocal = 10.7 - 11.4 See separate 'h report for further information. Test performed at: Gross Dictation Microscopic/Diagnostic Dictation: Final Reviev Final Review: Pathologist. Final: Pathologist, Addendum: Pathologist, ( Addendum Final: Pathologist, '
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diff --git a/output/text/12b90c26-a47c-469e-9c67-8b0c860b9cb8.txt b/output/text/12b90c26-a47c-469e-9c67-8b0c860b9cb8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3cd99f5b595d43ab76e406f952b8339abfb648a2
--- /dev/null
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+
+--- Page 1 ---
+1CD-0-3 Cnrciioma,mfiItnshnq 1obular, Nos 85xcf3 RH Sip:Brsst,uoq C50.4 119/ cQcF Sife: Brsot, w03 c50.9 Diagnosis: Skin and fatty tissue with small foci of resorptive inflammatory reactions and also incipient scarring. But no evidence of carcinoma. A regional R0 status is therefore likely to have been attained. Diagnosis: Invasive lobular breast carcinoma (maximum tumor diameter 2.7 cm, malignancy grade 2) with an invasive satellite node and multicentric, in parts confluent LIN formations (grade I). Remaining glandular body fibrolipomatous and with cystic duct ectasia, also small focal areas of adenosis. Submitted tissue samples of cutaneous/subcutaneous tissue histologically unremarkable. Tumor-free resection margins. Minimum width of dorsal safety margin 0.6 cm. Tumor classification: pT2m (maximum diameter 2.7 cm), pN0 sn (0/2) (compare xxxxx), MX, R0, G2 (L0, V0). UUID:E4D30B42-383A-40BF-B891-511A90227655 TCGA-A8-A0AB-01A-PR Redacted
\ No newline at end of file
diff --git a/output/text/12bbaa63-7b12-446e-94ec-29c7164fa9b6.txt b/output/text/12bbaa63-7b12-446e-94ec-29c7164fa9b6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7e485958b137b28d571897aadbc460418bfd1277
--- /dev/null
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+
+--- Page 1 ---
+Diagnosis: Resected colon sample (sigma) with tumor-free oral and aboral resection margins and. including an ulcerated, moderately differentiated adenocarcinoma with infiltration of the. lamina muscularis propria and without local lymph node metastases (G2, pT2, L0, V0, RO pN0 0/19).
\ No newline at end of file
diff --git a/output/text/12cc1f27-3e19-45a1-8401-089602f8865b.txt b/output/text/12cc1f27-3e19-45a1-8401-089602f8865b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7ac5eb21af27bc7f00a00f58e5f36d14700b1c43
--- /dev/null
+++ b/output/text/12cc1f27-3e19-45a1-8401-089602f8865b.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Page 1 of 3 UUID:F2ED454A-150F-4114-A0FA-4382705AAA02 Redacted TCGA-IB-A5SO-01A-PR Note: If you do not see "END OF PRINTED REPORT" at the bottom of the  the report YOu DO NOt HAVe The EnTIre REPOrt. Please try print. JOB CONFIDENTIAL SURGICAL PATHOLOGY REPORT Time Collected Time Reported Order Number Ordering Provider Status Final Relevant Information Location zed-o-3 Adensarcinome, duectal os Copied To 8503 Report Patient Name: Site : JevdQ parcuao Demographics (for verification Date of Birth: CQ5.0 purposes) Sex: M fS 4/2/13 SUrGiCAL PAThOLOgy REPORT *Surgical Pathology Report Accession Number Collected Date/Time Received Date/Time Pathologist Specimen Description A) Omentum B) Node of importance C) Whipple Specimen D) Superior mesenteric artery margin E) SMA Margin # 2 F Portal vein resection Clinical Information Pancreatic Cancer Infectious patient:No Immunocompromised: No History of neoplasm: No Diagnosis A: Omentum, Resection:  Benign fatty tissue with focal hemorrhage B: Lymph Node, (Node of Importance), Excision: Two benign, reactive lymph nodes (0/2) C: Distal Stomach, Head of Pancreas, Bile Duct, and Proximal Duodenum, Whipple Resection: Moderately differentiated invasive adenocarcinoma involving the
+
+--- Page 2 ---
+Page 2 of 3 head of the pancreas and wall of the duodenum (see synoptic report for details) Soft Tissue, (Superior Mesenteric Artery). Excision:.  Metastatic adenocarcinoma is present in one lymph node (l/l). No extranodal soft tissue extension is seen. Benign fibroadipcse tissue is also noted E: Soft Tissue, (SMA margin #2), Excision: No Invasive adenocarcinoma is present in fibroadipose tissue.. vascular involvement is identified. Four benign lymph nodes are present (0/4) F: Soft Tissue, (Portal Vein), Excision:. Invasive adenocarcinoma is present in fibroconnective tissue and within the wall of a large vein. Adenocarcinoma is also present in one of two lymph nodes (1/2). Electronically signed by: Synoptic Report c: Pancreas (Exocrine), Macroscopic. SPECIMEN: Head of pancreas Duodenum Stomach Common bile duct Adjacent large vessels Portal vein Other large vessel:  superior mesenteric artery PROCEDURE: Pancreaticoduodenectomy (Whipple resection), partial pancreatectomy TUMOR SITE: Pancreatic head TUMOR SIZE: Greatest dimension: 3.8 cm C: Pancreas (Exocrine), Microscopic. HISTOLOGIC TYPE: Ductal adenocarcinoma HISTOLOGIC GRADE: G2: Moderately differentiated MICROSCOPIC TUMOR EXTENSION: Tumor invades duodenal wall Tumor invades peripancreatic soft tissues MARGINS: Margins uninvolved by invasive carcinoma. mm Distance of invasive carcinoma from closest margin: Specified margin: pancreatic IREArmENt EFrecr (applicable to carcinomas treated with neoadjuvant therapy): Not known LYMPH-VASCULAR INVASION: Present PERINEURAL INVASION: Present PRIMARY TUMOR (pT): pT3: Tumor extends beyond the pancreas but without involvement of the celiac axis or the superior mesenteric artery REGICNAL LYMPH NODES (pN): pN1:  Regional lymph node metastasis.
+
+--- Page 3 ---
+Page 3 of 3 Number examined: Number involved: ADDITIONAL PATHOLOGIC FINDINGS: Chronic pancreatitis tunor involves the portal vein CLINICAL HISTORY: Not specified Gross Description Received are specimens A to w All reauisitions and specimen containers are labelled The cassettes and AP identifiers are with the patient's name, labelled with the Surgical Number A. The specimen is received fresh, labelled "omentum" and consists of an irregular. portion of hemorrhagic fatty tissue measuring 35 x 12 x 1 cm. Apart from the hemorrhagic areas, the tissue is unremarkable. Representative sections are submitted in Al to A3. B. The specimen is received fresh, labelled "node of importance", and consists of fragments of yellow- red soft tissue which measure together approximately 2.5 x 1.0 x 0.4 cm. Submitted in toto in cassettes Bl and B2. C. The specimen is received fresh, labelled "whipple specimen", and consists of a resection of the proximal duodenum, distal stomach, and head of pancreas. The common bile duct is identified via a stent and this is removed to reveal a dilated bile duct. measuring up to 1 cm in diameter and 4 cm in length. The ampulla demonstrates a slightly irregular granular area which measures 1.3 cm in diameter. The surrounding gastric and duodenal mucosa are otherwise unremarkable. On sectioning deep to the ampuliary region, the pancreatic head is diffusely abnormal and appears replaced by a fibrotic whitish process measuring 3.8 cm. There is no well defined lesion within this although variable areas of fibrosis, hemorrhagic, and microcystic change are noted.No normal pancreas is identified. Cl- Bile duct resection margin c2- proximal gastric margin c3- distal duodenal margin C4-- pancreatic resection margin C5-c10- pancreas lesion C11-c15- potential lymph nodes. D. The specimen is received fresh, labelled "superior mesenteric artery margin", and consists of an irregular portion of fibroadipose tissue measuring 2.3 x 1.6'x 0.5 cm. Submitted in toto in a single cassette Dl. E. The specimen is received fresh labelled "smA margin # 2", and consists of an irregular portion of yellow-white fibroadipose tissue measuring 3.0 x 2.5 x 1.5 cm. On sectioning, the tissue demonstrates firm white fibrotic tissue. Specimen is bisected and submitted in. toto in cassettes El and E2. F. The specimen is received fresh, labelled "portal vein resection", and consists of an irregular portion of fibroadipose soft tissue measuring 4.8 x 2.5 x 1.6 cm. On sectioning, the tissue is firm and fibrous, but no focal lesions are identified and no vessel lumen is seen. Representative sections are submitted in Fl and F2. Accession Number Encounter Number Patient Location  End of printed report --
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diff --git a/output/text/12f9e2e5-4534-4d0d-97d9-1a9252a71ead.txt b/output/text/12f9e2e5-4534-4d0d-97d9-1a9252a71ead.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e62bcf25d665d3d60f11d9b9006454081a2a845a
--- /dev/null
+++ b/output/text/12f9e2e5-4534-4d0d-97d9-1a9252a71ead.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UUID:DD289E47-8C67-4599-B0B6-0D30DE727B55 TCGA-S3-AA15-01A-PR Redacted MRN: Patient: Sex/DOB: Female Admission Date: Discharge Date: Ordering Physician: Surgical Pathology Report.. Collected Date/Time: Accession Number: Received Date/Time: Final Diagnosis A. RIGHT SENTINEL LYMPH NODE, EXCISION: - METASTATIC CARCINOMA TO ONE LYMPH NODE (1/1). - THE FROZEN SECTION DIAGNOSIS IS CONFIRMED. - SEE SPECIAL STAINS AND SYNOPTIC REPORT. B. RIGHT BREAST, MASTECTOMY WITH AXILLARY LYMPH NODES DISSECTION: - INVASIVE DUCTAL CARCINOMA, GRADE 3, MEASURING 1.1 CM, EXTENDING TO 5 MM FROM THE CLOSEST POSTERIOR RESECTION MARGIN, WITH LYMPHOVASCULAR INVASION. - DUCTAL CARCINOMA IN-SITU, NUCLEAR GRADE 3, WITH FOCAL NECROSIS, EXTENDING TO MORE THAN 5 MM FROM THE CLOSEST POSTERIOR RESECTION MARGIN. - MICROMETASTATIC CARCINOMA (0.21 MM) TO 1 OF 12 AXILLARY LYMPH NODES (1/12). - HEALING BIOPSY SITE WITH ORGANIZING HEMATOMA. - SKIN AND NIPPLE WITH SCLEROSING ADENOSIS. - SEE SYNOPTIC REPORT AND SPECIAL STAINS. tcD6-3 Wsenoins,inkiltstiigduot NS (Electronic signature) 0 U8s0>f3 Verified: Ste DyrsrotNoS Synoptic Report C56.9 SPECIMEN: Total breast (including nipple and skin)  yErast, uppe snmer quadia! PROCEDURE: es82 Total mastectomy (including nipple and skin) LYMPH NODE SAMPLING: l qfa4114 Axillary dissection (partial or complete dissection) SPECIMEN INTEGRITY:S Single intact specimen (margins can be evaluated) SPECIMEN SIZE: Greatest dimension: 30 cm Printed by: Page 1 of 5 Print Date/Time: Copied to: Distribute to: Patient Locations:
+
+--- Page 2 ---
+MRN: Patient: Sex/DOB:  Female Surgical Pathology Report Collected Date/Time: Accession Number: Received Date/Time: Additional dimensions: 22 X 7 cm SPECIMEN LATERALITY: Right TUMOR SITE: INVASIVE CARCINOMA:S Upper inner quadrant TUMOR SIZE: SIZE OF LARGEST INVASIVE CARCINOMA: Microinvasion only (<=0.1 cm) Greatest dimension of largest focus of invasion over 0.1 cm: 1.1 cm. TUMOR FOCALITY: Single focus of invasive carcinoma  MACROSCOPIC AND MICROSCOPIC EXTENT OF TUMOR: Skin: Invasive carcinoma does not invade into the dermis or epidermis. DUCTAL CARCINOMA IN SITU (DCIS): DCIS is present Extensive intraductal component (EIC)negative NUCLEAR GRADE: Grade III (high) NECROSIS: Present, focal (small foci or single cell necrosis) HISTOLOGIC TYPE OF INVASIVE CARCINOMA: Invasive ductal carcinoma (no special type or not otherwise specified). GLANDULAR (ACINAR)/TUBULAR DIFFERENTIATION: Score3: <10% of tumor area forming glandular/tubular structures NUCLEAR PLEOMORPHISM: Score 3: Vesicular nuclei, often with prominent nucleoli, exhibiting marked variation in size and shape, occasionally with very large and bizarre forms MITOTIC COUNT: Score 2 Number of mitoses per 10 high-power fields: 17 Diameter of microscope field: 0.55 mm OVERALL GRADE: Grade 3: scores of 8 or 9 MARGINS Margins uninvolved by invasive carcinoma Distance from closest margin: POSTERIOR 5 mm Distance from anterior margin: >5 mm Margins uninvolved by DCIS (if present) Distance from anterior margin: >5 mm Distance from posterior margin: >5 mm TREATMENT EFFECT: RESPONSE TO PRESURGICAL THERAPY: IN THE BREAST: No known presurgical therapy TREATMENT EFFECT: RESPONSE TO PRESURGICAL THERAPY: IN THE LYMPH NODES: No known presurgical therapy LYMPH-VASCULAR INVASION: Present Page 2 of 5 Print Date/Time::
+
+--- Page 3 ---
+MRN: Patient: Sex/DOB: Female Surgical Pathology Report ... Collected Date/Time: Accession Number: Received Date/Time: DERMAL LYMPH-VASCULAR INVASION: Not identified LYMPH NODES: Number of sentinel lymph nodes cxamined: 1 Total number of lymph nodes examined (sentinel and nonsentinel): 13 Number of lymph nodes with macrometastases (>0.2 cm): 1 Number of Iymph nodes with micrometastases (>0.2 mm to 0.2 cm and/or >200 cells): 1 Number of lymph nodes with isolated tumor cells (less than or equal to 0.2 mm and less than or equal to 200 cells): 0 Size of largest metastatic deposit: 0.9 CM. EXTRANODAL EXTENSION:S Not identified  METHOD OF EVALUATION OF SENTINAL LYMPH NODES: Hematoxylin and eosin (H&E), one level.  PRIMARY TUMOR (INVASIVE CARCINOMA (pT): pT1c: Tumor >10 mm but less than or equal to 20 mm in greatest dimension REGIONAL LYMPH NODES (pN): pN1a: Metastases in 1 to 3 axillary lymph nodes, at least 1 metastasis greater than 2.0 mm. DISTANT METASTASIS (M): Not applicable ESTROGEN RECEPTOR: Performed on another specimen Specimen (accession number): PROGESTERONE RECEPTOR:S Performed on another specimen Specimen (accession number): HER2/NEU IMMUNOPEROXIDASE STUDIES: Performed on another specimen Specimen (accession number): MICROCALCIFICATIONS: Not identified CLINICAL HISTORY: Mass or architectural distortion Source of Specimen A Lymph Nodes, Rt. Sentinel B RT Breast and Axillary Nodes I & II Clinical Information African American female with right breast cancer, silk marks axilla upper inner quadrant. PRE-OP DIAGNOSIS: Right breast cancer POST-OP DIAGNOSIS: Same TYPE OF PROCEDURE: Right breast mastectomy and Sentinel node biopsy Gross Description Page 3 of 5 Print Date/Time:
+
+--- Page 4 ---
+MRN: Patient: Sex/DOB: Female Surgical Pathology Report.. Collected Date/Time: Accession Number: Received Date/Time: Specimen is received in 2 parts: A.The specimen is labeled "RIGHr SENTINEL NODE" and is received unfixed for frozen section diagnosis. (The specimen is in the formalin more than 6 hours and less than 48 hours). It consists of a large lymph node measuring 3.5 x 2 x 2 cm. Sectioned and entirely submitted in cassettes FSA 1-FSA3. Time specimen was removed from the patient: Time specimen was placed in formalin : Ischemic time: 27 minutes B. The specimen is labeled *RIGHr BREAST AND AXILLARY NODES I AND II" and is received in formalin. (The specimen is in the formalin more than 6 hours and less than 48 hours). It consist of mastectomy specimen with lymph nodes weighing 1150.  grams and measuring 30 x 22 x 7 cm with brown skin ellipse measuring 21 x 10 cm, containing grossly unremarkable 2.0 cm in. diameter nipple. The skin is tagged with a black stitch designating the axilla . The posterior margin is composed of smooth fascia which is inked black. The breast is sliced in sagittal planes revealing a 5 x 5 x 4 cm hemorrhagic cavity within the upper inner-central yellow mammary fat with streaks of white-gray mammary parenchyma. Representative sections are submitted as follows: B1 = one lymph node, bisected B2 -- one lymph node, bisected B3 = one lymph node, bisected B4 = 5 lymph nodes B5 = 2 lymph nodes, one bisected.  B6 = one lymph node, bisected B7 = one lymph node, bisected B8 -- one lymph node, bisected B9-B12 = upper inner quadrant-central mass B13 = mass closest to deep fascial margin of resection B14 = nipple B15 = upper inner quadrant B16 = upper outer quadrant B17 = lower outer quadrant B18 - lower inner quadrant B19-28= additional sections from biopsy cavity. Time specimen was removed from the patient: Time specimen was placed in formalin : Ischemic time: 18 minutes Dictated by: Intra Operative Consultation Right sentinel lymph node: one lymph node, positive for carcinoma (1/1). . Special Stains / Slides Immunohistochemical studies were performed on formalin fixed, paraffin-embedded tissue (Block B2, B5, B6) with adequate positive and negative control sections. Immunostains for keratins AE1/AE3 are negative for carcinoma. Page 4 of 5 Print Date/Time:
+
+--- Page 5 ---
+MRN: Patient: Sex/DOB:  Female Surgical Pathology Report Collected Date/Time: Accession Number: Received Date/Time: The performance characteristics of these antibodies were determined by the. They have not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for research. This laboratory is Tissue Code Page 5 of 5 Case is (circle): DISQUALIFIED
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diff --git a/output/text/130b59fa-8aad-43cc-9ec9-16d4d26473f5.txt b/output/text/130b59fa-8aad-43cc-9ec9-16d4d26473f5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..603fab2b28cdb420c828a1233a4f5d9e02b57afd
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Date Coll: SURGICAL PATHOLOGY REPORT SPECIMEN Right colon CLINICAL NOTES PRE-OP DIAGNOSIS:  Carcinoma of the hepatic flexure. GROSS DESCRIPTION Received fresh labeled "right colon" is a previously unopened, 12 cm segment of proximal right colon with. attached 6 cm of distal ileum surfaced by smooth to scabrous tan-pink serosa with a moderate amount of attached mesocolon, mesentery and unremarkable omentum.  An unremarkable 6.6 cm appendix averaging 0.5 cm in diameter is present. The proximal and distal. margins measure 2.8. and 5 cm circumference respectively. On opening, there is a nearly circumferential, 10.8 x 8 cm partially necrotic dusky tan-gray-red tumor mass, 4 cm distal to the ileoceca valve. On sectioning, the tumor has a maximum thickness of 2.4 cm, grossly extending into the muscularis to within 1.1 cm of the inked free radial serosal surface..  The ileal and remaining colonic mucosa is unremarkable, glistening tan-pink with regular folds and the walls average 0.5 cm in thickness.  Several slightly rubbery pale tan-white tissues in keeping with lymph nodes measuring up to 1.4 cm in greatest dimension are recovered from the attached mesocolon and. mesentery. Representative sections are submitted in 15 blocks as. labeled. BLOCK SUMMARY: 1 - Proximal and distal margin; 2, 3 - tumor full. thickness to ink free radial serosal surface (orange); 4 - central. tumor; 5 - tumor to normal mucosa; 6 - Icv; 7 - random colon; 8 appendix; 9, 10, six whole lymph es per cassette; 11-15 bisected lymph node per cassette. MICROSCOPIC DESCRIPTION Histologic type:  Adenocarcinoma with mucinous differentiation. Histologic grade: Moderately differentiated. Primary tumor (pT):  Extends through muscularis propria (pT3) Proximal margin: Not involved Distal margin:  Not involved Circumferential (radial) margin: Not involved. Vascular invasion: Not identified Regional lymph nodes (pN): No evidence of metastasis in 18 nodes (pN0) Non-lymph node pericolonic tumor:.  Not identified Distant metastasis (pM) : Cannot be evaluated by this specimen (pMX) Other findings:  None 5
+
+--- Page 2 ---
+DIAGNOSIS Right colon, resection:. Adenocarcinoma, moderately differentiated, with mucinous differentiation, 10.8 cm with invasion through the muscularis propria. Surgical margins uninvolved. No evidence of metastasis in 18 lymph nodes (0/18). Appendix, appendectomy:. No pathologic diagnosis. - End Of Report.
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diff --git a/output/text/13124f82-c33c-406f-87dd-19bb23f0c00c.txt b/output/text/13124f82-c33c-406f-87dd-19bb23f0c00c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..be1078f8e30c38817d3c0f9c976deffe29de258b
--- /dev/null
+++ b/output/text/13124f82-c33c-406f-87dd-19bb23f0c00c.txt
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+
+--- Page 1 ---
+1cs-0-3 Crcnoma, infittnatrg ductl Nos 85o/3 Srfe: busst, nos C50.9 s1sh h Diagnosis: A: Lymph node, right axillary sentinel #1, removal - No metastatic carcinoma identified in one lymph node (0/1) B: Lymph node, right axillary sentinel #2, removal - Isolated tumor cell cluster (ITC) identified (on H and E) in one lymph node, 0.12 mm in greatest dimension, negative for extracapsular extension (see comment) C: Lymph node, left axillary sentinel #1, removal - No metastatic carcinoma identified in one lymph node (0/1) D: Lymph node, left axillary sentinel #2, removal - No metastatic carcinoma identified in one lymph node (0/1) E: Breast, right, total mastectomy Tumor Histologic Type: invasive ductal carcinoma Nottingham Combined Histologic Grade: 3 (9 of 9) UUID:71CEC5F6-16E5-46E1-A918-B5E0F6998231 Tubule formation score: 3 TCGA-AQ-A043-01A-PR Nuclear pleomorphism score: 3 Redacted Mitotic Count Score: 3 Focality of tumor: unifocal Tumor size (greatest dimension): 2.7 cm (by gross examination) Lymphovascular invasion: not identified In Situ component: present In Situ component type/architecture pattern: ductal carcinoma in situ (DCIS);  solid, comedo, micropapillary and cribriform patterns In Situ component nuclear grade: 3 In Situ component necrosis: present In Situ component extent/size: DCIS comprises approximately 50% of the tumor and is present admixed with and adjacent to invasive carcinoma Margin Status: Invasive component: widely negative
+
+--- Page 2 ---
+In Situ component: widely negative Microcalcifications: present associated with in situ and invasive carcinoma. Hormone receptor studies: results will be issued in an addendum report Other findings: - Biopsy site changes. - Proliferative fibrocystic change including sclerosing adenosis. - Duct ectasia AJCC PATHOLOGIC TNM STAGE: pT2 pN0(i+) pMx Note: The pathologic stage assessment is based on information available at the time of this report, and is subject to change pending clinical review and additional information. F: Breast, left, total mastectomy - Lobular carcinoma in situ - Proliferative fibrocystic change - Duct ectasia - No invasive carcinoma identified Comment: The frozen sections of the right axillary sentinel lymph node # 2 (specimen B). are reviewed and are negative for tumor cells. The isolated tumor cells are only identified on the permanent section levels. Intraoperative Consult Diagnosis: FSA1: Right axillary sentinel lymph node #1, biopsy - No tumor seen (0/1) FSB1: Right axillary sentinel lymph node #2, biopsy. - No tumor seen (0/1) FSC1: Lymph node, left axillary sentinel lymph node #1, biopsy - Negative for metastatic carcinoma in one lymph node (0/1). FSD1: Left axillary sentinel node #2, biopsy. - Negative for metastatic carcinoma in one lymph node (0/1) Gross Description: Received are six appropriately labeled containers. Specimens A-D are received. fresh for frozen section.. Container A is additionally labeled "right axillary sentinel lymph node #1." It.
+
+--- Page 3 ---
+holds a 1.5 x 1.0 x 1.0 cm lymph node candidate which is serially sectioned and entirely frozen as FSA1 Container B is additionally labeled "right axillary sentinel lymph node #2." It holds a 1.5 x 1.0 x 1.0 cm yellow/tan lymph node candidate which is serially sectioned and entirely submitted in block FSB1 Container C is additionally labeled "left axillary sentinel lymph node #1." It holds a 2 x 1 x 1 cm aggregate of yellow/tan fibrofatty tissue containing one. lymph node candidate which is serially sectioned and frozen as FsC1. A small amount of fat remains in formalin. Container D is additionally labeled "left axillary sentinel lymph node #2." It holds a 1 x 1 x 1 cm fragment of yellow/tan fibrofatty tissue which is serially sectioned and entirely frozen as FSD1 Container E: Specimen fixation: formalin Time in fixative: 9 hours. Type of mastectomy: total Size of specimen: 25 cm medial to lateral, 20.5 cm superior to inferior, 6.0 cm anterior to posterior; weighing 890 grams Orientation of specimen: There is a long suture lateral, and a short suture. superior. The specimen is inked as follows: superior/blue, inferior/red, deep/black. The specimen is sectioned from medial towards lateral.. Skin ellipse dimensions: 18 x 10 cm Nipple/areola: 1.0 cm/3.0 cm Axillary tail: not present. Biopsy site: not identified Residual tumor: present Location of tumor: upper outer quadrant; The tumor is a centrally necrotic, ill-defined mass which is 2.7 x 2.5 x 2.3 cm. Distance of mass/biopsy site from surgical margin: The tumor is located 1.3 cm
+
+--- Page 4 ---
+from the black inked posterior margin, 2 cm from. the blue inked superior soft tissue margin, 8 cm from the red inked inferior soft tissue margin, 3 cm subjacent to the skin, 5. cm from the lateral margin and remote from the medial margin. Gross involvement of skin or fascia/muscle by tumor: absent Description of remainder of breast: composed primarily of fat intermixed with yellow/tan, centrally dense fibroconnective tissue with multiple cysts measuring up to 0.8 cm in greatest dimension Other remarkable features: The tumor is surrounded by dark blue dye staining. Tissue submitted for special investigations: tumor and normal are given to Tissue Procurement Digital photograph taken: none Block Summary: (Inking: superior-blue, inferior-red, deep-black). E1 - nipple, serially sectioned E2 - areola, en face E3 - central tumor E4 - tumor and black inked deep margin. E5 - closest blue inked superior margin E6-E7 - sections of tumor in relationship to adjacent breast parenchyma E8 - upper inner quadrant E9 - lower inner quadrant. E10 - upper outer quadrant E11 - lower outer quadrant Container F: Specimen fixation: formalin Time in fixative: 8.5 hours. Type of mastectomy: total Size of specimen: 22 cm medial to lateral, 25 cm superior to inferior, 5 cm  anterior to posterior; 990 grams Orientation of specimen: Long suture-lateral, short suture-superior Inking: superior-green, inferior-red, deep-black; The specimen is sectioned from medial towards lateral.
+
+--- Page 5 ---
+Skin ellipse dimensions: 17.5 x 9.0 cm Nipple/areola: 1.1 cm/3.5 cm Axillary tail: not present Biopsy site: not identified Residual tumor: not present Description of remainder of breast: composed primarily of fat intermixed with. centrally dense white/tan, slightly nodular fibrofatty tissue with multiple cysts measuring up to 1.3 cm in greatest dimension Other remarkable features: There is focal blue dye staining in the central to lower inner quadrant of the breast Tissue submitted for special investigations: normal is given to Tissue Procurement Digital photograph taken: none Block Summary: (Inking: superior-green, inferior-red, deep-black) F1 - nipple, serially sectioned F2 - areola, en face. F3-F4 - upper inner quadrant F5-F6 - lower inner quadrant F7-F8 - upper outer quadrant F9-F10 - lower outer quadrant F11-F12 - central/subareolar Procedures/Addenda: Addendum Addendum The following addendum is issued to report the results of estrogen receptor, progesterone receptor, and HER2/neu immunohistochemical studies. Results: Estrogen receptor . clone SP1): Interpretation: NEGATIVE
+
+--- Page 6 ---
+Computer-assisted quantitative score: 0% Progesterone receptor ( clone 1E2): Interpretation: NEGATIVE Computer-assisted quantitative score: 0% HER2/neu ! clone 4B5, FDA-approved): Interpretation: NEGATIVE Computer-assisted quantitative score: 0 Site: right breast Performed on block: E3 Fixation: 10% neutral buffered formalin. Fixation time: 6-48 hours. Reference range: Estrogen receptor and progesterone receptor: <1%=NEGATIVE, 1-10% WEAK POSITIVE, >10% POSITIVE HER2/neu: 0,1=NEGATIVE FOR OVEREXPRESSION, 2=INDETERMINATE 3=POSITIVE FOR OVEREXPRESSION Comment: The quantitative scores reported above were obtained using the FDA-approved The control slides for this case show. appropriate staining. Some of the immunohistochemical reagents used in this case may be classified as analyte specific reagents (ASR) or research use only (RUO) reagents. These were developed and have performance characteristics determined by the These reagents have not been cleared or approved by the US Food and Drug Administration (FDA). The FDA has determined that such clearance or approval is not necessary. These tests. are used for clinical purposes. They should not be regarded as investigational. or for research. This laboratory is certified under the Clinical Laboratory. Improvement Amendments of 1988 (CLIA-88) as qualified to perform high complexity. clinical laboratory testing.
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diff --git a/output/text/1352674a-5770-4b39-9de7-6f9e60fe96b2.txt b/output/text/1352674a-5770-4b39-9de7-6f9e60fe96b2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..55bc87a391958e33a8ecb8de393ba79e9b2e39ed
--- /dev/null
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+
+--- Page 1 ---
+page 1 / 1 Department of Cancer Pathology Date: Examination: Histopathological examination. Internal invoice No. Cost of diagnostic procedure Examination No.: Patient: XXX PEsEL: XXX Age: Gender: F 1 cs-o-3 Material: Multiple organ resection -tight breast with axillary tissues Coicin ona bifi1tnstng duct,N0s 85of Unit in charge: 1 Site: buset,nos  Physician in charge: C50.9 h Material collected on: : Material received on: : 4/13u Expected time of examination: up to 8 working days. Clinical diagnosis: Cancer of the right breast. Examination performed on: Results of immunohistochemical examination: Estrogen receptors found in over 75% of neoplastic cell nuclei.. Progesterone receptors found in over 75% of neoplastic cell nuclei. HER2 protein stained with HercepTestTM by DAKO. Negative reaction in invasive cancerous cells ( Score = 1+ ). Compliance validated by: Examination performed on: Macroscopic description: Right breast sized 26 x 17 x 7 cm removed along with axillary tissues sized 10 x 14 x 6 cm and a skin flap of 16 x 8 cm. Tumour.  sized 3.2 x 2.5 x 1.9 cm in the upper outer quadrant, located 4.5 cm from the upper boundary, 1.7 cm from the base and 1.2 cm from the skin. Seven separate pieces with 3 x 2 x 1 cm in total. Microscopic description: Carcinoma ductale invasivum NHG2 (2 + 3 + 1/15 mitoses/10 HPF - visual area 0.55 mm). Extensive fibrosis in the central part of the tumour. Numerous signet ring celi. Mamilla sine laesionibus. Glandular tissue showing lesions of the type mastopathia fibrosa et lipomatosis. Axillary lymph nodes: Metastases carcinomatosae in lymphonodis (No II/vil). Histopathological diagnosis: Invasive ductal carcinoma of the right breast? Metastases carcinomatosae in lymphonodis axillae (No II/Vul). (NHG2; pT2; pNla). Cancer metastases in axillary lymph nodes. Compliance validat CONTACT YOUR DOCTOR WITH THIS REPORT! UUID:D9A0E659-99BC-4704-AC85-E63098BA7310 TCGA-D8-A1XR-01A-PR Redacted
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diff --git a/output/text/13568569-df99-4995-8963-2a3ba6784d40.txt b/output/text/13568569-df99-4995-8963-2a3ba6784d40.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8f4802d57ccfeb110eab3a462dc3c9258a672408
--- /dev/null
+++ b/output/text/13568569-df99-4995-8963-2a3ba6784d40.txt
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+
+--- Page 1 ---
+Collection Date: FINAL DIAgNOSIS: Part 1: Distal Left mainstem, BIOpsy: A.  Suboptimal, minute fragment Consists Of bronchial mucosA. B.  No tumor seen. Part 2: bronchus Intermedius biopsy: A.  minute fragment Of Bronchial mucOsa with minimal inflAmmation. B.  NO TUMOR SEEN. Part 3: Left gastric tissue, biopsy: Fragment Of fiBrous-aDipose tissue with single Lymph node negative for maLIgnancy (0/1). LCD-O3 Part 4: paraeSOphageal Lymph node near pericardium, eXcisiOn:  NO tumOR SEEn in TWO Lymph nODES (0/2) srcinomnd,sgamsis b 8s7813 PART 5: PARAESOPhAGEAL LymPH NODE, EXCISON: ceQQ nO3 NO TUMOR SEEN IN SINGLE LYMPH NODE (O/1). C6c r Part 6: ParAeSOphageal Lymph nOde near CaRinA: Satc Mioislle thuo NO tumor Seen in three lymph nodes (0/3).. Part 7: paraeSOphageal Lymph node near Left main bronchus, excision: NO tumor cells in A single lymph nooe (0/1).. Jhs ueisy lsy 25 part 8: esophagus, esophagectomy: A. WeLl DIfFERENTiATED SQuAmOUS CELL CARcINOma WITH EXOPhytIC/ PaPilLARy GrOwtH PATTeRN, MULTIfOCAL (TWO POLyPOID/EXOPHyTiC MASSES IDEnTIFIeD 3.5 Cm AnD 1.5 Cm IN GREATESt DImENSiON RESPECTIVELY). a. TUMORS INVADE SUPERFICIAL DUPLICAT's LAYERS OF MUSCULARIS MUCOSAE (T1a). b. NO AngiOlymphaTIc inVaSiOn PRESent. c. NO PERINEURAL INVASION IDENTIFIED. d. NO TUMOR SEEN IN TWO LYMPH NODES (O/2). e. PROXIMAL AND GASTRIC RESECT!ON mARGiNS (see parts 9, 10, 12 and 13) AND ADVentIT!AL MArgins free of tumor. f. PATHOLOgIC STAGE (AJCC 7TH Ed): pT1b, N0. B.  UninvolVed esOphAgeal mucOsa wIth: a. MARKED AND DIFFUSE ACANTHOSIS. b. FOcal Barrett s mucosa identifieD at esophageal-gastric Junction. C.  UnInVOLVED gASTRiC muCOSA WItH OXynTIC CELLS hyPERPLASIA AnD FOCAL gLAnDS CYSTiC Dilatation; Changes Suggestive Of proton pomp inhibitor therapy (ppit). Part 9: ESOphageal margin, resection: A.  ESOphAgeaL MArGiN NEGATIVe fOR mALIGNAnCy. B. EsophageaL epithelium with rEactive Changes. Part 10: most proximal mArgin, resectiOn: Fragment Of esOphagus negative fOr maLignancy, with fOcal Chronic inflammation. part 11: gastroesophageal fat, resection: FrAGmentS Of ADIpOSe tISsue wIth TWeLVe Lymph nODeS NEgAtIVe fOr mALIgnAncy (0/12). PARt 12:  Eea final margin, resection: A. Fragment Of gastric Oxyntic mucosA, negative for malignancy, with focal chronIC INFLAMMATION. B. Separate fragment Of eSOphagus negative fOr malignancy. PArt 13:  fInal Gastric margin, resecTion:  FrAgment Of gastric OxyntIc mucOSa nEgaTive fOr mAlignanCy. B.  Diffuse mucosa congestion. UUID:8E288022-B4B3-46F1-84A1-4F1ECC8ABB7D TCgA-IC-A6RF-01A-pR Redacted
+
+--- Page 2 ---
+CASE SYNOPSIS:  SynOpTic DATa - PRImARy eSOphAgeAl TUmORSE . -- MACROSCOPIC - - Esophagogastrectomy Specimen type:  Midthoracic esophagus (10-15cm from EGJ) TUMOR SITe: Greatest dimension: 3.5 cm Tumor size: Additional dimensions: 2.5 x 0.3 cm - MICROSCOPIC - hIStoLOgiC type:  Squamous cell carcinoma HIStOLOgIC GRADE: G1 PathOlOgiC Staging (pTnm)  m (multiple primary tumors) pT1a pN0 Number of lymph nodes examined: 22 Number of lymph nodes involved: 0 17 or more regional lymph nodes were identified pM Not applicable Prior treatment: No prior treatment MARGINS  Proximal margin uninvolved by invasive carcinoma. Proximal margin uninvolved by dysplasia  Proximal margin uninvoived by intestinal metaplasia. Distal margin uninvolved by invasive carcinoma Distal margin uninvolved by dysplasia Distal margin uninvolved by intestinal metaplasia. Circumferential (adventitial) margin uninvolved by invasive carcinoma. Distance of invasive carcinoma from closest margin: 15 mm. Specify margin: proximal resection margin ANGIOLYmPHATIC INVASION: Absent ADDITiONAl PaThOLOgIc FinDiNgS: intestinal metaplasia (Barrett's esophagus)  High grade dysplasia Comment: Tumor site: two lesions were identified : one cm 3.5 at midesophagus 7.0 cm far from the GE  junction and the second lesion (1.5 cm) located 5.5 cm far from GEJ.
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diff --git a/output/text/136c1c2e-474f-43d6-b020-756b3409a75f.txt b/output/text/136c1c2e-474f-43d6-b020-756b3409a75f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ff7dd748efc2cb108d17f2e6afc7becfb951d1f4
--- /dev/null
+++ b/output/text/136c1c2e-474f-43d6-b020-756b3409a75f.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Methsttc Lynph Node UUID: 57341F00-74F5-4015-B6D4-7BDED33F35A7 tcga-e2-a15e-06a-pr Redacted TSS: SPECIMENS: jc -0 - 3 A. SENTINEL LN #1 LEFT AXILLA B. LEFT BREAST MASS C. LEFT AXILLARY CONTENTS LEVELS 1,2 8300/3 SPECIMEN(S): A. SENTiNEL LN #1 LEFT AXILLA Site: /ynpk mode, axilary B. LEFT BREAST MASS C. LEFT AXILLARY CONTENTS LEVELS 1,2 c 77 3 lu GROSS DESCRIPTION: A. SENTINEL LN #1 LEFT AXILLA 3/5714 Received fresh is a tan pink firm grossly positive lymph node 1.3 x 0.8 x 0.5cm. Toto A1.. B. LEFT BREAST MASS Received fresh labeled with the patient's identification and "left breast needle localization" is an oriented 27g, 5.5 x 5 x 3cm needle localized lumpectomy with radiograph. Ink code: anterior-yellow, posterior-black, superior-blue, inferior- orange, medial-green, lateral-red. Specimen is serially sectioned from medial to lateral into 7 slices revealing a 2 x 1.5 x 1.5cm tan pink ill defined mass, closest to anterior margin at 0.4 cm in slices 2-6. A portion of the specimen is. submitted for tissue procurement. Representatively submitted: B1: medial margin slice 1 B2: mass slice 2 B3-B5: slice 3 B6-B9: slice 4 B10-B12: slice 5 B13: mass slice 6 B14-B16: lateral margin slice 7 C. LEFT AXILLARY CONTENTS LEVELS 1, 2  Received fresh are multiple tan pink soft tissue fragments aggregating to 5 x 4 x 2cm. Dissection reveals 12 lymph nodes ranging from 0.1 x 0.1 x 0.1cm to 1.3 x 1 x 1cm. C1: 4 lymph nodes C2: 4 lymph nodes C3: 3 lymph nodes C4: 1 lymph node C5-C11: axillary tissue DIAGNOSIS: A. SENTINEL LYMPH NODE 1, LEFT AXILLA, BIOPSY: - METASTATIC CARCINOMA (1.3 CM IN SIZE) TO ONE LYMPH NODE WITH NO EXTRANODAL EXTENSION (1/1). B. BREAST, LEFT, NEEDLE LOCALIZATION WIDE LOCAL EXCISION: - INVASIVE DUCTAL CARCINOMA, SBR GRADE 3.E - TUMOR MEASURES 1.1 CM - TUMOR IS 0.3 CM FROM THE ANTERIOR MARGIN - DUCTAL CARCINOMA IN SITU (DCIS), SOLID TYPE, NUCLEARI GRADE 3, WITH NECROSIS, MINOR COMPONENT.E - LOBULAR CARCINOMA IN SITU (LCIS), INVOLVING A RADIAL SCAR. - RADIAL SCAR WITH USUAL DUCTAL HYPERPLASIA AND MICROCALCIFICATIONS. C. AXILLARY CONTENTS, LEFT, LEVELS 1 AND 2, DISSECTION: - EIGHT LYMPH NODES, NO TUMOR SEEN (0/8). SYNOPTIC REPORT - BREAST Specimen Type:  Excision Needle Localization: Yes Laterality: Left Invasive Tumor: Present Multifocality: No WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Tumor size: 1.1cm
+
+--- Page 2 ---
+Tumor Site: 9:00 Margins: Negative Tubular Score: 3 Nuclear Grade: 3 Mitotic Score: 3 Modified Scarff Bloom Richardson Grade: 3 Necrosis: Absent Vascular/Lymphatic Invasion: Present Lobular neoplasia: LCIS Lymph nodes: Sentinel lymph node and axillary dissection Lymph node status:. Positive 1/9 DCIS present Margins uninvolved by DCIS. DCIS Quantity:Estimate 2% DCIS Type: Solid DCIS Location:Associated with invasive tumor Nuclear grade: High Necrosis: Present Location of CA++: Benign epithelium ER/PR/HER2 Results ER: Positive PR: Positive HER2: Positive by FISH Pathological staging (pTN): pT 1c N 1 SYNOPTIC REPORT - BREAST, ER/PR RESULTSE Specimen: Surgical Excision Block Number: A1 (lymph node with metastasis) ER: Positive Allred Score: 8 = Proportion Score 5 + Intensity Score 3 PR: Positive Allred Score: 8 = Proportion Score 5 + Intensity Score 3 COMMENT: The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score. (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring range from 0 to 8.  ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2. METHODOLOGY:  Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Immunohistochemistry was performed using the mouse anti-human ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) provided by following the manufacturer s instructions. This assay was not modified. Interpretation of the ER/PR immunohistochemical stain is guided by published results in the medical literature,.  information provided by the reagent manufacturer and by internal review of staining performance. CLINICAL HISTORY: year-old female with invasive ductal carcinoma of left breast PRE-OPERATIVE DIAGNOSIS:  Invasive ductal carcinoma INTRAOPERATIVE CONSULTATION: TPA: SLN #1- Positive for metastatic carcinoma. Diagnosis called to Dr. at by Dr. Gross Dictation: Microscopic/Diagnostic Dictation: Pathologist,. Final Review: Pathologist,. Final: Pathologist, h nud Mttstatc Axil/sy 3/5/14 Criteria Diagno
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diff --git a/output/text/139dc9ae-089b-4b68-a7c2-751d89eec858.txt b/output/text/139dc9ae-089b-4b68-a7c2-751d89eec858.txt
new file mode 100644
index 0000000000000000000000000000000000000000..cd3147299df775724b36cc0d7761dc39c139c23e
--- /dev/null
+++ b/output/text/139dc9ae-089b-4b68-a7c2-751d89eec858.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+LCD6*2 teo 9680/3 jrjh MsQ,inginel C 77 4 LEFT INGUINAL LYMPH NODE: FO s33i/14 Multiples tissue fragments, which measure 3,4 x 2,8 x 0,6 cm. INGuINAL LEFt LympH NODE (EXCiSIOn): - DIFFUSE LARGE B-CELL LYMPHOMA The sections correspond to a lymph node which shows a complete deletion of the architecture by a vaguely nodular proliferation with extensively diffuse areas. The tumor is composed of a monotonous proliferation of atypical large cells of centroblastic type with mitotic and apoptotic figures. The inmunohistochemistry study has shown positivity of atypical large cells for CD20, CD79a, CD10, bcl-6 and bcI-2, and negativity for MUM1. Stains for follicular dendritic cells (CD21, CD35) highlight the diffuse growth of the neoplasia. There is a moderate expansion of T cells positive for CD3 and CD5. The Ki67 proliferation index is higher than 80%. FISH: A rearrangement of the MYC gene has been found. END
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diff --git a/output/text/139ee1b1-f575-4a15-9cf2-485dfad41be6.txt b/output/text/139ee1b1-f575-4a15-9cf2-485dfad41be6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3db6cac3a6466b75d390f9eb34c79fd2bb7a9926
--- /dev/null
+++ b/output/text/139ee1b1-f575-4a15-9cf2-485dfad41be6.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:5D85E578-64B4-4238-922E-80288ED87800 TCGA-XX-A89A-01A-PR Redacted LQD-O.3 arcinsno, vifiltinteiey lelulor NDS Qee 8520|3 Research Gross Description Mrsoet Nos C so.9 Research Dx YBressj uiper -seitor Left breast (1945 g), mastectomy: Invasive lobular carcinoma. C se.4 Readianf 7 regional lymph nodes, negative for malignancy (0/7) Tumor site: Upper outer quadrant ( 2-3:00) D(i/zz)3 Tumor size: Between 7 and 9 cm Histopathologic type: Invasive lobular carcinoma. Histopathologic grade (Nottingham): 2 Mitotic count: Low proliferative rate Pathologic tumor stage: pT3 Margin status:. Distance of carcinoma from margins: Superior: 0.8 cm Inferior: At least 1 cm Medial: Greater than 2 cm Lateral: Greater than 2 cm Anterior: 1 cm Posterior: Greater than 1 cm Associated in situ carcinoma: Type: Lobular carcinoma in situ (rare focus) Extensive (>25% of total tumor): No Separate (extra-tumoral) foci away from main lesion: Not identified Peritumoral angiolymphatic invasion: Not identified. Dermal angiolymphatic invasion: Not identified. Estrogen receptor: Positive (70 % of tumor cell nuclei staining moderately to strongly) Progesterone receptor: Positive (70 % of tumor cell nuclei staining moderately to strongly) HER-2/neu (ERBB2): Negative (score 0) Duration of fixation in 10% NBF: 12 hours 24 minutes. Appropriate internal and external controls: Yes Standard assay conditions met? Yes Pathologic lymph node stage: pN0 (including sentinel): No regional lymph node metastasis Number of nodes positive for metastasis/total number nodes sampled: 0/11 Maximum diameter of largest lymph node metastasis: Not applicable Extranodal extension by tumor: Not applicable Distant metastasis: M-not applicable Additional pathologic findings: Fibrocystic change and usual ductal hyperplasia; seborrheic keratosis TNM descriptors (if applicable):. AJCC Staging (7th Edition): pT3 pN0 M-not applicable Research QC T1 Tumor: 50% tumor nuclei 0% necrosis 50% normal Normal: 100% fibroadipose
+
+--- Page 2 ---
+T2 50% tumor nuclei 0% necrosis 50% normal fibrous tissue and fat. minimal normal breast T3) 70% tumor nuclei 0% necrosis 30% normal T4 50% tumor nuclei 0% necrosis 50% normal fat, could prob be trimmed Research Specimen Specimen Process Time Blood draw time Plasma frozen time: Serum frozen time Buffy coat frozen time: Cold ischemia start time: Formalin fixation start time: Total cold ischemia time: Formalin fixation stopped time Total formalin fixation time: Specimen Weight Cryovials x 8 Normal x 4 - 1.) 335 mg 2.) 321 mg 3.) 408 mg 4.) 447 mg Tumor x 4 -1.) 351 mg 2.) 357 mg 3.) 252 mg 4.) 322 mg Specimen Size Plasma x 3 Serum x 2 Buffy coat x 1 Cryovials x 8 Normal x 4 Tumor x 4 FFPE x 8 Normal x 4 Tumor x 4 Study h 10/24/3 Patient Consent Yes
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diff --git a/output/text/13afc144-8d16-4c2e-9fb5-8418e088dda2.txt b/output/text/13afc144-8d16-4c2e-9fb5-8418e088dda2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c695906ffc5d387a87d0a2d67b1998b6a298ab16
--- /dev/null
+++ b/output/text/13afc144-8d16-4c2e-9fb5-8418e088dda2.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+I@DD3 UUID:94A1D757-7DE9-4D98-97AB-B6BD66C2CB3B 8Q60|3 TCGA-5P-A93Y-01A-PR Redacted tJ e/3/4 Papillary Renal Cell Carcinoma, Type I. Stage: pT2, RO Grade: GII ICD-0-Code: 8260/3 Lateraihy li b/9fH
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diff --git a/output/text/13bc9f3e-304d-4e5c-bab7-1398712ed1fe.txt b/output/text/13bc9f3e-304d-4e5c-bab7-1398712ed1fe.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d140877844c3a84b459db44d9bf9efd43e224259
--- /dev/null
+++ b/output/text/13bc9f3e-304d-4e5c-bab7-1398712ed1fe.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+RUN DATE: PAGE 1 RUN TIME: RUN USER: User : PATIENT: ACCr #: AGE/SX: ROOM: REG: DOB: BED: DIS: REG DR: STATUS : SPEC #: RECD: STATUS : COLL : TIME IN FORMALIN: 7:55 hrs. CLINICAL INFORMATION: Pre-Op Diagnosis: Colon cancer Remarks: IGD-o3 Specimen(s): A. Retroperitoneal lymph node B. Transverse colon ideresssiune Nos 814o13 Site ranoveue colow q18.4 MIC:ROSCOPIC DIAGNOSIS AJ 6/3/13 A.  RETROPERITONEAL LYMPH NODE. EXCISION:  METASTATIC ADENOCARCINOMA CONSISTENT WITH METASTATIC COLON CARCINOMA  TRANSVERSE COLON, SEGMENTAL RESECTION: HIGH-GRADE ADENOCARCINOMA TUMOR MEASURES 4.5 CM IN GREATEST DIMENSION AND EXTENDS THROUGH THE COLON WALL INTO SUBSEROSAL FAT (pT3) SURGICAL MARGINS OF RESECTION FREE OF TUMOR WITH CLOSEST MARGIN 2.5 CM RADIAL METASTATIC ADENOCARCINOMA IN 6 OF 12 SUBSEROSAL LYMPH NODES SEE COMMENT FOR SURGICAL PATHOLOGY CANCER CASE SUMMARY CHECK LISTS COMMENT(S) CAP APPROVED SURGICAL PATHOLOGY CANCER CASE SUMMARY: COLON AND RECTUM UUID:163923CC-A65E-4F0F-83CC-D0CA33C8F35E Transverse colon TCGA-NH-A6GB-01A-PR Redacted SPECIMEN: PROCEDURE : Transverse colectomy TUMOR SITE: Transverse colon MACROSCOPIC TUMOR PERFORATION: Not identified HISTOLOGIC TYPE: Adenocarcinoma HISTOLOGIC GRADE: High-grade MICROSCOPIC TUMOR EXTENSION: Tumor invades through the muscularis propria into the. subserosal adipose tissue or the nonperitonealized pericolic or perirectal soft tissues but does not extend to the serosal surface. MARGINS Distance of invasive carcinoma from closest margin: 25 cm Proximal margin: Uninvolved by invasive carcinoma Distal margin: Uninvolved by invasive carcinoma. Circumferential or mesenteric margin: Uninvolved by invasive carcinoma TREATMENT EFFECT: No prior treatment ** CONTINUED ON NEXT PAGE **
+
+--- Page 2 ---
+RUN DATE: PAGE 2 RUN TIME: RUN USER: User: SPEC #: PATIENT: COMMENT(S) (Continued) LYMPH-VASCULAR INVASION : Not identified PERINEURAL INVASION: Not identified PATHOLOGIC STAGING:S Primary tumor: pT3. Regional Iymph nodes: pN2b. Number of lymph nodes examined: 13. Number of lymph nodes involved: 7 Distance metastasis: Not applicable GROSS DESCRIPTION: A. Received fresh for frozen section labeled with the patient's name and "retroperitoneal node" is a 1.7 x 1.5 x 0.5 cm ovoid tan lymph node. On cross section, the node has a pale grayish-tan color and focally contains an area suspicious for a metastasis. A representative section is submitted in block A1 for frozen section. A cytologic touch prep. is prepared for Diff-Quik stain. The remainder of the tissue is submitted in block A2. B. Received fresh for tissue banking and labeled with the patient's name and "transverse colon". Received is a 12.5 cm segment of large bowel. The large bowel is recoived with a 22.0 x 12.0 x 1.7 cm portion of yellow. lobulated. omental adipose. The attached omentum makes the specimen consistent with transverse colon. The segment of bowel is received unoriented between proximal and distal. There is a focal area of serosal puckering with "creeping fat". The area is inked blue and the bowel is opened to have a centrally ulcerated. 4.5 x 4.0 cm tumor mass. The tumor mass is nearly circumferential and has raised. rolled borders. The tumor comes to within 5 cm of one margin and 2.5 cm of the opposite margin. The tumor diffusely involves the bowel wall and focally axtends through the bowel wall to superficially invade the underlying yellow adipose. The tumor focally appears to abut the inked serosa. There is 2.5 cm of yellow adipose between the tumor and. the mesenteric fat resection margin. The surrounding mucosa is unremarkable with normal. tan folds. The fat is sectioned and scant. possible lymph nodes are identified. Representative sections are sampled as labeled: B1-B2 margins B3 porpendicular sections of nearest radial fat margin B4 representative sections of omental adipose. B5-B7 representative sections of tumor to include areas of deepest invasion and tumor to serosa. B8-B9 whole lymph nodes. B10 ons lymph node bisected MICROSCOPIC DESCRIPTION: The slides are examined and evaluated. ** CONTINUED ON NEXT PAGE **
+
+--- Page 3 ---
+RUN DATE : PAGE 3 RUN TIME: RUN USER: PATIENT: (Continued) SPEC #: INTRAOPERATIVE CONSULTATION: FROZEN SECTION: RETROPERITONEAL LYMPH NODE : METASTATIC ADENOCARCINOMA CONSISTENT WITH COLORECTAL PRIMARY RESULTS GIVEN TO IN THE OPERATING ROOM AT Signed .(signature on file).. ** END OF REPORT * lw 5/23/13 ISQUALIFIE
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diff --git a/output/text/13f4779b-5a6c-46fd-9848-4ea56e12743c.txt b/output/text/13f4779b-5a6c-46fd-9848-4ea56e12743c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..63918b2fb72b7d0ff873dca67cf865e5b1726f50
--- /dev/null
+++ b/output/text/13f4779b-5a6c-46fd-9848-4ea56e12743c.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1) SPECIMEN LABELED "RIGHT COLON ADENocARcINoMA (1l.8 cm), poorly differentiated, with neuroendocrine and signet ring cell features and focal mucin production. Tumor extends through the muscularis propria and involves the visceral peritoneum, The proximal, distal, and radial resection margins are free of tumor. Lymphovascular invasion is present. Appendix with fibrous obliteration and peri-appendiceal adhesions. METASTATIC CARCINOMA in one of thirty two (1:32) lymph nodes. CLINICAL DATA: History: None given. Operation: Rt colectomy clinical Diagnosis: Colon cancer abeled with the The specimen is received fresh, patient's name,unit numberand "1) Rt colon tumor bank)and consists of a partial colectomy specimen consisting of terminal ileum (8 cm length, 3.1 cm diameter,colon (27 cm length,4.5 cm diameter)appendix (4.5 cm length0.5 cm diameter),proximal stapled resection margin (4.1 cm)and distal stapled resection margin (4.6 cm. There is a red/tan, ulcerating, necrotic mass (11.8 x 5.5 x 5.0 cm with raised rolled borders at the ileocecal valve, extending through the wall creating a large, matted mass within the pericolonic fat, The mass is 8 cm from the extending to and possibly involving the appendix. proximal stapled resection margin, and 23 cm from the distal stapled resection margin. A tan mucosal polyp 0.4 x 0.3 x 0.2 cm is present 5.5 cm distal to the aforementioned ileocecal valve mass, and comes to within 18 cm of the distal stapled resection margin, and 17 cm of the proximal stapled resection The margin. The remaining colonic mucosa is tan/pink with normal folds. ileomucosa is tan/pink and velvety, with focally flattened folds adjacent to the mass. Multiple tan/white, indurated to tan/pink, rubbery lymph nodes are identified, ranging from 0.5-l.5 cm in greatest dimension. Representative sections of the tumor and normal colon, as well as half of a lymph node are submitted to the tumor bank for special studies. Micro 1: proximal stapled resection margin en face,2 frag, Micro 2: distal stapled resection margin, en face,2 frag, Micro 3: appendix tip-bisected, and mid appendix,3 frag, Micro 4 appendiceal os in relation to cecal/ileocecal mass, ileocecal valve mass, deepest extension frag, Micro 5-6: Micro 7: mass in relation to right colon, 1 frag, Micro nal ileum,1 frag, 8: mass in relation to ileocecal valve and Micro 9: additional colon mucosal polyp, 2 frag, remaining half of grossly positive lymph node (remainder to bank), Micro 10: 1frag, Micro 11: five single whole lymph nodes 12: seven single whole lymph nodes 7frag Micro Micro 13: eight single whole lymph nodes, 8 frag Micro 14: Micro 15: five signle whole lymph nodes, 5frag, SPECIMEN TYPE: COLONSEGMENTAL RESECT FOR TUMOR
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diff --git a/output/text/1415daa7-2a7c-4306-bc40-2f36b7133329.txt b/output/text/1415daa7-2a7c-4306-bc40-2f36b7133329.txt
new file mode 100644
index 0000000000000000000000000000000000000000..08be43e031b96aff01d1bf246f6f48f0a061c5fa
--- /dev/null
+++ b/output/text/1415daa7-2a7c-4306-bc40-2f36b7133329.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Sex:F Source of Specimen(s): 1:Para caval Lymph Node 2:Right Kidney, resection 3:Para caval Lymph Node 4:Peri renal fat Gross Description: Received in four parts. Source of tissue:1.Labeled#1,paracaval lymph node (VERIFIED). Intraoperative Consultation:NO TUMOR SEEN PER Gross Description: Reccived fresh for frozen section diagnosis labeled paracaval lymph nodeis a 1.8 x 1.1 x 0.6 cm brownish-tan firm rounded lymph node.Submitted entirely for frozen section as1FSA. ****************************** Source of tissue:2.Labeled#2"right kidncy Gross Description:Received fresh labeled " right kidney"is a 273 gram/13 x 7 x 5 cm kidney partially covered by retractcd perinephric fat.Upon sectioning, obliterating approximately two-thirds of the kidney by volume located within the mid/inferior pole is a 8.5 x 5.5 x 5.0 cm hemorrhagic golden orangish-tan partially necrotic, encapsulated rounded tumor mass.Along the outer surface vantage point this mass appears very unevenly lobulated, and some points appcar to extend through the capsule to the inked outer surfacc. Also,this impinging mass significant reduces the volume of the pelvocaliceal collecting system, and the remaining viewable pclvic mucosa appears pale-tan and glistening.The outer superior pole kidney surface is lobulated, and this somewhat normal appearing renal parcnchyma has somewhat demarcated corticomcdullary borders with a cortex thickness of 0.9 cm. Upon opening, the 13.5 x 0.5 cm uninvolved uretcr has an unremarkable mucosal surface, and a very short vein segment is probed closely along, but uninvolved by a tumor edge. Within the hilar fat are three pale grayish white hard rounded mctastatic appcaring lymph nodes ranging in size 0.4-0.9 cm, and within the superior pole fat is a 0.9 cm hemorrhagic firmness for probable lymph node,and no obvious adrenal gland. Represcntative sections9. Designation of Sections:2A vascular and ureteral margins.2B/2C capsule invasion?,and tumor in relation to normal kidney.2D additional tumor along outer surface.2E/2F tumor in relation to pclvic mucosa.2G tumor in relation to vein.2H superior pole.2I lymph nodes. *********************************************************** Source of tissue:3.Labeled #3,"paracaval lymph node'
+
+--- Page 2 ---
+Gross Description:Received fresh labeled" paracaval lymph node" is an 8 x 1.5 x 0.5 cm portion of soft lobulated fat containing four potential lymph nodes ranging in sizc 0.2-1.9 cm.The largest lymph node is color-coded by the application of black ink prior to sectioning. Entirely submitted in 3A. *********************************************************** Source of tissue:4.Labcled #4,"fat around kidney" Gross Description:Received fresh labeled" fat around kidncyis a 6.5 x 5.5 x 0.4 cm portion of partially hemorrhagic soft lobulated fat.Upon palpation, the 0.3 x 0.2 cm firm focus is designated by the application of black ink.Otherwise, there are no other obvious findings.Representative sections1 k******* Final Diagnosis: 1.Paracaval lymph node, excision -No tumor seen in one lymph node, (0/1). 2.Right kidney,nephrectomy: -Papillary renal ccll carcinoma type 2, 8.5 cminvolving renal sinus and perinephric fat. -Surgical resection margins are free of carcinoma -Metastatic papillary renal cell carcinoma involving four of five hilar. lymph nodes,4/5. -Extracapsular cxtension is identificd 3.Paracaval lymph nodes,excision: -No tumor seen in eight lymph nodes,0/8) 4.Fat around kidney,excision: -Benign adipose tissue. pTNM:T3 N2 Mx
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diff --git a/output/text/14e445c4-8d86-4c0c-a3da-fd4612206b8f.txt b/output/text/14e445c4-8d86-4c0c-a3da-fd4612206b8f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d505edf093ee5ebee5c467bdb2fde513b2c8e550
--- /dev/null
+++ b/output/text/14e445c4-8d86-4c0c-a3da-fd4612206b8f.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+P.24/33 ParT 1: LEfT AXILLARy SENHNE ICCARCINOmA, EaCH DEPOSit A. TWO Lymph nODESA  MEASURING LESST B.  NO EXTRACAPSULARE Part 2: Left AxilLary Sentinel:! TWO LYMPH NODES, NEGATIVE FOR NEOPLASM (O/2). Part 3: Leet.breast.total mastectomy-  INEILTRATING DUCTAL CArCInOmA, nOTTINghAm GRADE 2 (nUCLEAR GRADE 2, TUBULE SCORE 3. A. Mitotic activity score 2; total score 7/9). B. Tumor measures 4.5 cm in greatest Dimension. C.  LYmphOVASCULAR SpACe InVAsIOn IS PRESENt. D. TumOR iS PRESEnt iN THe LOWer iNnEr QuaDRAnt. E.  margins are Negative for neoplasm: Tumor apprOaches mOst CLOseLy tO The AnTeriOr MARGIN (1.5 MM). F. FiBrocystic changes. 1Cs-0 -3 G.  Nipple skin is negative for neoplasm. carnoma nfilfrafng outd,nos 850cf3 H. .PATHOLOGIC STAGE: pT2 pN1mi pMX. CASE SYNOPSIS: Sits; brenst, Nos c50.9 3/13u hs SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST LATERALITY: Left PROceDure: Simple mastectomy LOCATION: Lower inner quadrant Size of tumor: Maximum dimension mvasive component: 4.5 cm MuLTiCenTRiciTy/muLTIfOCaLiTy Of invasivE fOCi: No Tumor type (invasive component): Ductal adenocarcinoma, NOS nOttingham score: Nuclear grade: 2 Tubulc formation: 3 Mitotic activity score: 2 Total Nottingham score: 7 Nottingham grade (1, 2, 3): 2 ANGIOLYMPHATIC INVASION: Yes DERMAL LYMPHATiC INVASION: No CAlCIfIcatiOn: No SURgICAL mArgINs inVOLVED by iNvASIVE COmpOnENt: No Distance of invasive turnor to dosesl margin: 1.5 mm Lymph nODes pOsITIve: 2 LYMPH nODES EXAMINED: 6 METHOD(S) Of LymPh NODE EXAminATION: H/F stain SENTINEL NODE METASTASIS: Yes OnLy KERATIn POSITiVE CElLS Are PrESEnt: No SIZE OF NODAl meTASTASES: Diameler of largast lymph node metastasis: 1 mm LYMPH NODE mETASTASIS(-ES) WITH EXTRACAPSULAR EXTeNSION: No T stage. pathologic: oT2 n stage, pathologic: pN1mi m stage, pathologic: pMX Estrogen Receptors:  positive PROGESTERONE RECEPTORS: positive HER2/NEU: 2+ UUID:891F4C63-8207-4CB8-A859-A970CC6F1A1A TCGA-BH-A0E1-01A-PR Redacted
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diff --git a/output/text/14f1d3fb-8418-4afd-88dc-ae73993adb97.txt b/output/text/14f1d3fb-8418-4afd-88dc-ae73993adb97.txt
new file mode 100644
index 0000000000000000000000000000000000000000..110ff10345bd4c3b0c6e684b80f5918ac9a37395
--- /dev/null
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+Puge I V3.00.110414 TCGA Missing Pathology Report Form Instructions; The TCGA Missing Pathology Report Form should be completed for cases for which a pathology report is not available. UUID:83F2C05D-6A43-433C-A7BC-EC62F4882E6D TCGA-G4-6317-02A-PR Redacted 7. Z016 Completed Date (MM/DD/YYYY): General Pathology Report Information # Data Element Entry Alternatives Working Instructions Provide the tumor type of the case.. COAD Tumor type: Indicate to which BCR location the case was originally sent.  BCR specimen originally sent.  nch 2 to: el IGC  Provide the date (MM/DD/YyyY) of shipment arrival at the Date specimen received at. 3 3Z0u Biospecimen Core Resource (BCR). 3 BCR:  ICD-O-3 Histology Code:  Provide the histology code for the sample from the Case Quality Control Form (CQCF) and the overall case (patient For Specimen: (CQCF) CQlF inompete diagnosis, if different). For Case: (patient 8140/3 diagnosis, if available. elsewhere)  ICD-O-3 Site Code: Provide the site code for the sample from the Case Quality Control Form (CQcF) and the overall case (patient diagnosis, if For Specimen: (CQCF)  CQCE incompuete different). For Case: (patient C18.9 diagnosis, if available. elsewhere)
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diff --git a/output/text/14fba30a-e0da-4721-bcd5-1e0f505ba208.txt b/output/text/14fba30a-e0da-4721-bcd5-1e0f505ba208.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9f2dfeee2ced19f5ecb7251a330ecceaff1712c6
--- /dev/null
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+
+--- Page 1 ---
+UUID:4EE74737-16F3-44DD-A18F-B418F17F6FAD TCGA-2Z-A9J6-01A-PR Redacted Pathology Report Final Diagnosis A. *LEFT RENAL MASS," PARTIAL NEPHRECTOMY: Renal cell carcinoma, papillary type 1, Fuhrman nuclear grade 2 of 4. See Key Pathological Findings. KEY PATHOLOGICAL FINDINGS Tumor type: Renal cell carcinoma, papillary type 1. Nuclear grade: Fuhrman nuclear grade 2 of 4.. Pattern of growth: Solid. Tumor size: 2.0 cm. Invasion through Renal capsule: Not identified. Invasion of Gerota's Fascia: Not applicable Renal vein invasion: Not applicable. Surgical margins. Free. Non-neoplastic kidney. Mild chronic inflammation and focal glomerulosclerosis. Adrenal gland: Not applicable Lymph nodes: Not applicable. Pathologic stage: pT1aNXMX. I. the attending pathologist, personally reviewed the entire case and rendered the final diagnosis. Electronically Signed Out by ICD03 Specimen(s) Received 8Q6t|3 A  LEFT RENAL MASS Sit: CD Kidney Nt) Clinical History C 64.9 -year-old male with left renal mass. 4/Q8/14 Preoperative Diagnosis Not given. Frozen Section Diagnosis FSA1: LEFT RENAL MASS: Renal cell carcinoma with papillary features. Margin negative. Comment: This frozen section diagnosis/result was communicated to and acknowledged by Dr in OR M.D., have perfarmed the intraoperative consultation and issued the above diagnosis.
+
+--- Page 2 ---
+Gross Description A. The specimen is received fresh labeled *left renal mass". The specimen consists of a 2.0 x 1.8 x 1.5 cm mass surrounded by a rim of renal parenchyma. This rim ranges in size from 0.2 to 0.8. cm. The specimen is inked as follows: Blue: Capsule around tumor. Green and black:. Renal parenchymal margin The specimen is serially sectioned to reveal a tan-yellow, homogenous and well-encapsulated mass. that does not involve the renal capsule or perinephric fat. The rim of renal parenchyma seems unremarkable. The specimen is submitted as follows: FSA1: Tumor and renal parenchymal margin submitted for frozen section diagnosis A2-A6: Sections of remaining tumor in relation to capsule and renal parenchyma Representative section of this tumor was submitted to the Tissue Procurement Laboratory.
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diff --git a/output/text/151204f2-a4ca-4b8a-ac16-ea72b07ec9b2.txt b/output/text/151204f2-a4ca-4b8a-ac16-ea72b07ec9b2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b41cf3daf750adb99865efc143acc582a080592f
--- /dev/null
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+/cs-0 -3 Carcin 0ma,nifiHtraHiny ouctal Nos 8500/3 1/28/n ID#: Srte: brast Nos c50.9 Pathology Form Specimen Information Collected by: Date: Time: Preserved by: Date. _Time:  SPECIMENTYPE(# of samples provided)A Frozen Paraffin Block Blood/Serum/Plasma Slide Diseased Normal Diseased Normal Diseased  Normal Diseased Normal x x x x * Time to LN2 Time to Formalin Time to LN2 min. min 60 min SATMOSRSAPATHOLOGICALDESCRIPTIONANRAMSEE Primary Tumor Organ Size Extension of Tumor Distance to NAT Rsewd 9.5 NO 9 cm. cm Lymph Nodes Location # Examined # Metastasized Axilla 5 Distant Metastasis  Organ Detailed Location Size NO Pathological Staging pT 9 N1 M Stage: R Notes: UUID:F043248B-F0B1-4948-9189-7833646029F1 CGA-C8 4
+
+--- Page 2 ---
+ID#: Microscopic Description ILSbio * rHistological Pattern.. Cell Distribution + Structural Pattern Diffuse +  Streaming Mosaic  Storiform Necrosis  Fibrosis  Lymphocytic Infiltration  Palisading Vascular Invasion  Cystic Degeneration Clusterized Bleeding  Alveolar Formation Myxoid Change Indian File Psammoma/Calcification  Squamous +- Adenomatous + Sarcomatous + Lymphomatous  Squamoid Cell Glandular cell  Round Cell  Large Cell Spindle Cell Cell Stratification  Fibroblast Small Cell Keratin  Secretion Osteoblast  RS Cell/RS Like Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell  Pear! Gland formation Myoblast  Plasma Cell Cellular Differentiation: Well X Moderate Poor Nuclear Atypia: 0 1 II III  Aniso Nucleosis  Hyperchromatism + Nucleolar Prominent +. Multinucleated Giant Cell Mitotic Activity Nuclear Grade: + Marker Result Value Date ER  Negative  Positive PR  Negative   Positive Her-2/neu  Negative  Positive B-Cell Marker  Negative  Positive T-Cell Marker  Negative   Positive Other:  Negative  Positive Other:  Negative   Positive Final Pathology Report Imvae Ductf Careinma Histological Diagnosis: Grade: Comments: Principal Investigator Pathologist Date
+
+--- Page 3 ---
+COnsOLIDaTeD DIagnOstIC paThOLOgy fOrm* Microscopic Appearance: 1 Histological pattern: CELL DISTRIBUTION Diffuse STRUCTURAL PATTERN Mosaic X Streaming + Necrosis A  Storiform Lymphocytic Infiltration Fibrosis Vascular Invasion x Palisading Clusterized Cystic Degeneration Alveolar Formation X Bleeding. Indian File X  Myxoid Change 2. Cellular features: X  Psammoma/Calcification Squamous + Adenomatous Squamoid Cell +  Sarcomatous Glandular cel! + Lymphomatous Spindle Cel! Round Cel! Cell Stratification Large Cell Keratin Fibroblast Secretion Small Cell Desmosome Osteoblast Intracyt. Vacuole RS CelVRS Like x  Pear! Lipoblast  Gland formation Inflam. Cel! Myoblast Otherwise Specified:. D1 407 j Plasma Cell 2.Cellular Differentiation: Well Moderately Poor Nuclear Atypia: 3. Nuclear Appearance  Aniso Nuclcosis 0 Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity Nuclear Grade Histological Diagnosis:TQ hltg rh betz Crnmmg sos 6 3 Comments: PATHOLOGIST STAFF FOR RESEARCH USE ONLY).E EGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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diff --git a/output/text/1516959c-f793-483e-b0a3-94ffd34c884e.txt b/output/text/1516959c-f793-483e-b0a3-94ffd34c884e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d1549e8af3ca2ecd3f20ab4224cceda5312c822f
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+
+--- Page 1 ---
+UUID:D4B803C9-2284-4B0A-90E7-FF86D56B1501 TCGA-KM-A7Q9-01B-PR Redacted Patient Results Page 1 of 4 Admit Date: Gender: Male Birth Date: Age: Attending: Admit Protocol:  Location: Surgical Pathology (OrderID: Final Results Surgical Pathology Final CASE NUMBER: IcD s-3 DIAGNOSIS: 1. Portion of right adrenal gland, frozen section (1FS): Adrenal Carcinoino,rinal eeIl gland, no tumor seen.. Chromsphobe type 83 1713 2. Kidney, cyst wall, right, resection: Fibrous tissue, no tumor Sit B$idreyNsS seen. c649 3. Kidney, tumor, right, resection: * Renal cell carcinoma chromophobe type with marked hemorrhage 9/24/13 and areas of fibrosis. * See Note. 4. Kidney, right, radical nephrectomy: * Renal parenchyma with chronic interstitial nephritis and moderate atherosclerosis, no tumor seen. * Ureteral and vascular margins free of tumor. * Vessels with organizing thrombus. * See Note. 5. Lymph nodes, paracaval, resection: Adipose tissue, no lymph nodes or tumor identified. NOTE: SURGICAL PATHOLOGY CANCER CASE SUMMARY Procedure: Radical nephrectomy Specimen Laterality: Right Tumor Size: 5.3 x 5.3 x 2 cm Tumor Focality: Unifocal Macroscopic Extent of Tumor: Tumor limited to kidney. Histologic Type: Chromophobe renal cell carcinoma. Sarcomatoid Features: Not identified Histologic Grade (Fuhrman Nuclear Grade): Not applicable Microscopic Tumor Extension: Tumor limited to kidney. Margins: Margins uninvolved by invasive carcinoma Lymph-Vascular Invasion: Not identified Pathologic Staging (pTNM) Primary Tumor (pT): pT1b Regional Lymph Nodes (pN): No nodes submitted or found Distant Metastasis (pM):Not applicable Pathologic Findings in Nonneoplastic Kidney: Chronic interstitial nephritis, atherosclerosis Immunoperoxidase and in-situ hybridization tests performed here and used for diagnosis were developed and their performance characteristics Contidential Patient Intormation. Unauthorized disclosure is prohibited by the Federal Privacy Act of 1974. JobID: Requested By: Do not file in Medical Record
+
+--- Page 2 ---
+Patient Results Page 2 of 4 Admit Protocol: Gender: Male Birth Date: Age: Admit Protocol: Admit Protocol: Location: Surgical Pathology (OrderID: Final Resultsd determined by the  They have not been cleared or approved by the U.s. Food and Drug Administration. The FDA has also determined that such dlearance or approval is not necessary. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA) as qualified to perform high complexity clinical laboratory testing. CLINICAL INFORMATION: Brief Clinical History: right renal tumor Specimen Taken For Protocol: 01 - Yes Allocate Order to Protocol: PROcEDuRE: Pre-Operative Diagnosis: right renal tumor Post-Operative Diagnosis: right renal tumor Operative Findings: tumor invading into segmental renal vein, enlarged retroperitoneal lymph nodes SPECIMENS SUBMITTED: 1. ADRENAL GLAND, RIGHT, Portion -1fs 2. KIDNEY, RIGHT, Cyst Wall 3. KIDNEY, RIGHT, Tumor 4. KIDNEY, RIGHT 5. LYMPH NODES, Paracaval INTRAOPERATIVE CONSULTATION: 1FS "Portion RT adrenal FS" 1FS DX: Benign adrenal cortex. The frozen section was performed by GROSS DESCRIPTION: 1. Received fresh from the OR labeled with the patient's name, medical record number, and date of birth, and further specified as "portion RT adrenal FS" is an irregularly-shaped red-tan soft tissue fragment measuring 1.7 x 1.2 x 0.7 cm, a portion of which is submitted for frozen section diagnosis as 1FS. The specimen is wrapped in lens paper, placed in a green cassette and transferred to formalin. The  specimen received in Surgical Pathology matches the above description. Frozen section specimen is transferred to an orange cassette labeled 1FS for permanent processing. The additional small fragment of tissue is filtered into a biopsy baa and entirely submitted in a white cassette labeled for permanent processing. 2. Received in formalin-filled container labeled with the patient's name, MRN, date of birth and "right kidney cyst wall" is a cauterized white to tan soft tissue fragment measuring 1.0 x 0.5 x 0.3 cm, entirely submitted in a white cassette labeled A for permanent processing. 3. Received in a container labeled with the patient's name, MRN, date Contidential Patient Information. Unauthorized disclosure is prohibited by the Federal Privacy Act of 1974. JobID: Requested By: Do not file in Medical Record
+
+--- Page 3 ---
+Patient Results Page 3 of 4 Admit Protocol: Birth Date: Age : Gender: Male Admit Protocol: Location: Admit Protocol: Surgical Pathology [OrderID: Final Results of birth and further specified as "right kidney tumor" is a partially disrupted partial nephrectomy specimen measuring 5.3 x 5.3 x 2 cm and weighing 63.3 grams. Gross photographs are taken. It is well-circumscribed with a mottled red to brown hemorrhagic cut surface. Approximately 2 x 1.5 x 1 cm of tumor procured for the The specimen is placed in formalin and submitted to Patholoay for permanent processing. Procurement was performed The specimen is received in Surgical Pathology and matches the above description. The specimen is further serially sectioned and. representative sections of central and periphera! tumor are submitted in cassettes 3A-3F for permanent processing. 4. Received fresh in a container labeled with the patient's name, MRN,. and further specified as "right kidney is an 842.8 g radical nephrectomy measuring oveall 25 x 13 x 4 cm. Gross photographs are taken. The posterior and part of the anterolateral portion of the  specimen are inked in black. Approximately 3 x 2 x 1 cm of normal  kidney parenchyma is procured. The remainder of the specimen is placed in formalin and submitted to Pathology for permanent processing. The. procurement was performed by. on The specimen is received in Surgical Pathology and matches the above description. 6.3 cm of ureter is present. The kidney is opened revealing a 5 x 5 cm area, where partial nephrectomy was performed. The lower pole within potentially fat or a structure is a yellow-tan hemorrhagic nodule. Summary of cassettes for permanent processing:. 4A: Vascular and ureteral margins. 4B: Upper pole parenchyma 4C: Representative section of vasculature from pelvis 4D: Representative section of the lower pole nodule 4E: Residual "tumor" in the nephrectomy cavity and 4G, 4H: Representative sections with central thrombi/hemorrhage from the posterior portion of the lower pole.  4I: Fascia in dosest contact with the mass 4J: Two additional representative sections from the lower pole 4K Two candidate lymph nodes from the renal pelvis 4L: Additional sections of ureteral margin 5. Received in a formalin-filled container labeled with the patient's name, MRN, date of birth, and further specified as "paracaval lymph node" is a 6.3 x 6.0 x 2.5 cm matted yellow fibroadipose tissue. The specimen is explored for lymph nodes. No candidate lymph nodes are. identified. Segment of fibrovascular tissue is submitted in cassettes 5A-5E for permanent processing.. Gross Description dictated by on  No consultants Accessioned: Final Report Signed Out: Contidential Patient Intonnation. Unauthorized disclosure is prohibited by the Federal Privacy Act of 1 974. JobID: Requested By: Do not file in Medical Record.
+
+--- Page 4 ---
+Patient Results Page 4 of 4 Admit Protocol: Gender: Male Birth Date: Age Admit Protocol: Admit Protocol: Location: Surgical Pathology [OrderID: Final Results} <Resident Signature> M.D. PhD. CLINICAL RESIDENT <Sign Out Dr. Signature> MD, ATTENDING STAFF PATHOLOGIST Date Report Signed: w4/13 Contidential Patient Infonnation. Unauthorized disclosure is prohibited by the Federal Privacy Act of 1974. JobID: Requested By: Do not file in Medical Record
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diff --git a/output/text/1524b824-8f81-4645-b9bd-b2b34dcbf447.txt b/output/text/1524b824-8f81-4645-b9bd-b2b34dcbf447.txt
new file mode 100644
index 0000000000000000000000000000000000000000..912a6d2f06ec237851690704b6b409673e0b86cb
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+
+--- Page 1 ---
+UUID:36C343AC-443B-4196-8B6D-7D9213F2DAE1 TCGA-2Y-A9H9-01A-PR Redacted Pathology Report ICD~O-3 'arenorns, hepstselOules NSS Final Diagnosis 81703 A. LYMPH NODE, PORTAL, EXCISION: Site:oluer CQx D Negative for metastalic carcinoma. J 4lQ8J14 B. LIVER.SEGMENT4LESION,BIOPSY: Fragment of liver parenchyma with macro and microvesicular steatosis and chronic portal inflammation. There is no evidence of malignancy. C LIVER, SUPERIOR SEGMENT 4, BIOPSY: Fragment of liver parenchyma with minimal portal intlammation.. There is no evidence of malignancy D. LIVER, ADDITIONAL SUPERIOR SEGMENT 4, BIOPSY: Fragment of liver parenchyma with chronic portal inflammation.. There is no evidence of malignancy E. LIVER, SEGMENT 6, BIOPSY: Fragment of liver parenchyma with microvesicular steatosis and portal inflammation.. There is no evidence ot malignancy. F. LIVER,SEGMENT6,RESECTION: Hepatocelular carcinoma, moderately differentiated, trabecular architecture. (see key pathologic findings) the attending pathologist, personally reviewed all. slides and / or materials and rendered the finai diagnosis. Electronically Signed Out by Key Pathological Findings F: Liver, Resection Specimen: Liver PROCEDURE: Partial hepatectomy *Minor hepatectomy (less than 3 segments) TUMOR SIZE: Greatest dimension:  4.0 cm. *Additional dimensions: 3.8 x 3.5 cm TUMOR FOCALITY: Solitary (specity location): segment 6 HISTOLOGIC TYPE:
+
+--- Page 2 ---
+Hepatocellular carcinoma HISTOLOGIC GRADE: GI: Well differentiated TUMOR ExTENSION (select all that apply): Tumor confined to liver  PRIMARY TUMOR (pT): pT2: Solitary tumor with vascular invasion or muttiple tumors none more than 5 cm  REGIONAL LYMPH NODES (pN): pNO: No regional lymph node metastasis DISTANT METASTASIS (pM): pMX: Cannot be assessed MARGINS: Parenchymal margin uninvolved by invasive carcinoma *VENOUS (LARGE VESSEL) INVASION (V): *Absent *ADDITIONAL PATHOLOGIC FINDINGS: *Hepatitis (specify type): Hepatitis C. Specimen(s) Received A  PORTAL LYMPH NODE FS B SEGMENT 4 LESION FS c SUPERIOR SEGMENT 4 FS D ADDITIONAL SUPERIOR SEGMENT 4 FS W u. SEGMENT 6 FS LIVER RESECTION SEGMENT 6 Clinical History None given Preoperative Diagnosis Hepatocellular carcinoma. Intraoperative Consultation FSA1. PORTAL LYMPH NODE: Negative. FSB1. SEGMENT 4LESION: Benign liver. FSC1. SUPERIOR SEGMENT 4 LESION: Benign liver. FSD1. ADDITIONAL SUPERIOR SEGMENT 4: Benign liver. FSE1. SEGMENT 6: Benign liver.
+
+--- Page 3 ---
+Comment: This frozen section diagnosis/result was communicated to and acknowledged by in at : on , have performed the intraoperative consultation and issued the above diagnosis. Gross Description The specimen is received fresh labeled "portal lymph node*. The specimen consists of a single roughly ovoid, rubbery lymph node measuring up to 2.0 cm in greatest dimension. The lymph node is bisected and is submitted entirely tor frozen section as FsA1. B The specimen is received fresh labeled "segment 4 lesion". The specimen consists of a single core biopsy fragment of tan brown tissue measuring 0.7 cm in length and less than 0.1 cm in diameter. The specimen is submitted entirely for frozen section as FsB1 C. The specimen is received fresh labeled *superior segment 4*. The specimen consists of a single core biopsy fragment of tan brown tissue measuring 1.1 cm in length and less than 0.1 cm in diameter. The specimen is submitted entirely for frozen section as FsC1. D. The specimen is received fresh labeled *additional superior segment 4*. The specimen consists of a single core biopsy fragment of tan brown tissue measuring up to 0.7 cm in length, which is submitted entirely for frozen section as FsD1. E. The specimen is received fresh labeled *segment 6*. The specimen consists of a single core biopsy fragment of tan brown tissue measuring 0.5 cm in length and less than 0.1 cm in diameter. The specimen is submitted entirely for frozen section as FSE1.. F. The specimen is received fresh labeled *liver resection segment 6". The specimen consists of. an irregular,unoriented fragment of liver parenchyma measuring 6.5 x 5.5 x 4.0 cm and weighs 79.0 grams. The capsule of the portion of liver is tan red brown, smooth and glistening. The parenchymal resection margin is shaggy. cauterized and is marked with black ink. The specimen is serialty. sectioned to reveal an irregular to roughly ovoid, well-defined, solid intraparenchymal tumor nodule, which measures 4.0 x 3.8 x 3.5 cm.The tumoris 0.3 cm from the closest parenchymal resection margin. The tumor partially bulges but does not appear to extend through the hepatic capsule. The cut surface of the tumor is variegated,pink tan to brown,focally hemorrhagic and lobulated. The hepatic capsule overlying tumor is marked with blue ink. Representative sectlons of the specimen are submitted to the Tissue Procurement Laboratory. Representative sections of the specimen are sulmitted in 6 cassettes as follows:. F1-F3: Tumor in relation to closest parenchymal resection margin F4-F6: Additional sections of the tumor bulging hepatic capsule. hw 1/2114
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diff --git a/output/text/15602ab6-089c-4831-bbd2-879c60ed6601.txt b/output/text/15602ab6-089c-4831-bbd2-879c60ed6601.txt
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index 0000000000000000000000000000000000000000..0e3ef12c015eb0a71e0466d93c21c5971c1fd3eb
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+--- Page 1 ---
+zeD-o-3 D 8Qb6/3 AMENDED/CORRECTED REPORT: Amended date: JtU s[x1]13 Reason: Correct laterality designation of the partial nephrectomy Paragraph of what changed: From right side to left side of Part 2 (diagnosis fieid). No other changes are made to the report. Communicated to by email on Original sign-out date:. This Amended Report supersedes all prior reports under this accession number and should be the only one used for patient  management. All reports, both original and amended, are maintained in electronic archives and are available upon request. FINAL DIAGNOSIS: Collection Date: Part 1: fat, OVerLyIng TumOR, rESecTIOn POrtIOn Of FisrOaDipOSe tissUe AnD One DetacheD SmALl FrAGment (0.1 Cm) Of RenAl CeLl CARCINOMA PRESENT (See Comment). Part 2: Left kidney, partial nephrectomy-- A.  RENAL CELL CARCINOMA WITH ONCOCYTIC FEATURES, FOAMY MACROPHAGES WITH FOCAL HEMOSIDERIN PIGMENT, AND IMMUNOREACTIVITY FOR ALPHA-METHYLACYL CoA RACEMASE; FAVOR RENAL CELL CarciNomA, PapILLAry Type 2 with A pReDominantly SOLid Architecture. B. FUHRMAN NUCLEAR GRADE IS 3 OUT OF 4. C.  NEOPLASM MEASURES 2.9 CM IN MAXIMUM DIMENSION. D.  neOpLAsm AppeArs Limited tO the kiDney with nO DefinItIve extracapSuLAr EXTensiOn IDENTIFIED. E.  NEOpLASm iS PReSENt fOCALLy AT The InKED CApSULAR AnD inKeD PAREnchymAl RESECTiON MARGINS. F.  NO LYMPHOVASCULAR INVASION IS IDENTIFIED. G.  NON-NeOpLASTIC KIDNey SHoWS Chronic ChAngES ASSOCiATed wth PRoxIMITy tO THe tUmOR. H. TNM PATHOLOGIC STAGE: pT1a Nx Mx (See SynoptIc and Comment). COMMENT: Part 2: The renat mass consists of an oncocytic eplthelial neoplasm with prominent foamy macrophages and. hemosiderin laden macrophages associated with hemorrhage. The epithelial cells are arranged in solid, acinar, and focally papillary architectures. The neoplastic cells have large nuclei with prominent nucleoli and round nuclear contours. A limlted panel of immunohistochemical stains is performed. The neoplastic cells are strongly immunoreactive for P504s (alpha-methylacyl CoA racemase) and are negative for cytokeratin 7 and carbonic anhydrase Ix. Parvalbumin  immunostain is equivocal, with a high background. The overall pathology favors a type 2 papillary renal cell carcinoma. Parts 1 and 2: The renal cell carcinoma Is focally present at the capsular resectlon margln in an area where the capsule is not intact (? capsular incision) and the parenchymal resection margin on the partial nephrectomy speclmen. A microscopic detached fragment of carcinoma is present in the fat overlying the tumor (part 1). It is uncertain whether any microscopic residual carcinoma is present. Clinical / radiologic follow-up is recommended. CASE SYNOPSIS: SyNOPTiC DATA - PRImARy KIDnEy TUmORS UUID:2240C6F0-5359-4A21-9275-B5D81F597168 SpeCimen Type: Partial nephrectomy TCGA-B1-A655-01A-PR Redacted LATeRALITY: Left Tumor site: Upper pole FOCALITY: Unifocal TUMOR SIZE: Greatest dimension: 2.9 cm Additional dimensions: 2.5 X 1.4 cm MACROSCOPIC EXTeNT OF TUMOR: Tumor limited to kidney HISTOLOgiC TYPe: Other: Oncocytic renal cell carcinoma, favor type 2 papillary histologic type HISTOLOGIC GRADE (Fuhrman Nuclear Grade): G3 PATHOLOGIC STAGING (pTNM): pT1a pNX  Number of regional lymph nodes axamined: 0 pMX MARGINS:  Margin(s) involved by invasive carcinoma Renal capsular margin. Perinephric fat margin. Renal parenchymal margin W 5/&1/13 ADRENAL GLAND: Not present Citerla iagnosisD LYMPH-VASCULAR INVASION (LVI): Absent/not identified mary Tumor S Dual'Sync
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diff --git a/output/text/15af5ecb-92c8-4ad2-9061-b658a40dec7a.txt b/output/text/15af5ecb-92c8-4ad2-9061-b658a40dec7a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5a1ec612e6a48e44e2a4a0c1afb60651037a37fe
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+--- Page 1 ---
+Carcinoms 80t/ .50.4 Patient: Sqcf : brint nos.. 50.9 Surgicalm Surg Path UUID:F2B21F52-74F4-44C5-9991-60EBCC4E43A6 CGA-B6-A0RI-01A-PR Redacted CLINICAL HISTORY: Not provided. GROSS EXAMINATION: Estrogen receptor tissue sent for estrogen and progesterone receptor. A. nTru-cut breast biopsy.": Received fresh. The specimen is a 1 cm x 0.1 cm tan piece of breast tissue. This frozen as frozen section AFl. The frozen section remnant consists of two pieces of tan tissue measuring 0.8 x 0.1 x 0.1 and 0.7 x 0.1 x 0.1 cm. They are submitted in toto in Block Al.. B. "Right breast.": Received fresh. The specimen consists of breast with an overlying ellipse of skin. The overall dimensions of the specimen are 15 x 11 x 2 cm with an attached axillary tail which in addition measures 7.8 x 3.5 cm. The skin ellipse measures 1l.5 x 4 cm in greatest dimensions. And contains a nipple at its center. The deep surgical margin is inked blue and made through the deep aspect of of the specimen revealing a 1.5 x 2.8 x 1.0 cm firm mass which radially retracts the adjacent breast tissue and which is located approximately 0.2 cm from the deep surgical margin at one point.  The mass appears located in the upper outer quadrant of the breast. Further sectioning through the specimen reveals unremarkable breast parenchyma in areas away from the tumor. Material submitted for ER/PR. Block Summary: B1 and B2-closest sections of tumor to the deep surgical margin inked blue. B3 and B4-Further sections of tumor to the deep surgical margin.. B5-Section through the nipple. B6-Representative sampling from the upper inner quadrant. B7-Representative sampling of the lower inner quadrant. B8-Representative sampling of the upper outer quadrant. B9-Representative sampling of the lower outer quadrant.. B10-Further sections through the lower outer quadrant. The axillary tail is dissected. Tumor margin has been marked with surgical suture.  These are present in zone 2 at the juncture with zone 1 and are submitted separately in Block Bll. B12-Sections of fat from zone 1 appear that no definite lymph nodes are identified in zone 1. B13-Candidate lymph nodes from zone 2. B14, 15 and B16-Candidate lymph nodes from zone 3. INTRA OPERATIVE CONSULTATION: AFl "Tru-cut breast biopsy": infiltrating ductal carcinoma.. DIAGNOSIS: A. "TRU CUT BREAST BIOPSY": INFILTRATING DUCTAL CARCINOMA. B. "RIGHT BREAST": 1. INFILTRATING DUCTAL CARCINOMA, NSABP HISTOLOGIC GRADE 3, NUCLEAR GRADE MODERATELY DIFFERENTIATED. THE TUMOR COMES WITHIN O.2 CMS OF THE DEEP MARGIN GROSSLY. THE TUMOR SIZE IS 1.5 X 2.8 X 1.0 CM. VASCULAR INVASION IS PRESENT. THE TUMOR IS LOCATED IN THE UPPER OUTER QUADRANT ONLY. 1 of 2
+
+--- Page 2 ---
+2. SIX OF FIFTEEN LYMPH NODES CONTAIN METASTATIC CARCINOMA. Verified by: AM 2 of 2
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index 0000000000000000000000000000000000000000..805bec9180b391c68a2ec273488150f640de01df
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+UUID: 30947748-8764-4060-BFF3-48FEF39F4BEA0 TcgA-AC-A3EH-01A-PR Redacted D.O.B.: WSNTSRECIMENNE Cotlected: Received: Reported: SURGICAL PATHOLOGY DIAGNOSIS: Sreast, right, axillary contents; modified radical mastectomy and axillary node dissection:. Tumor Characterlstics: Histologic type: Pleomorphic lobular carcinoma, confirmed by negative e-cadherin stain.. Size: 10.0x 10.0 x7.2 cm. Tumor focality: Unifocal. Elston modification of Bloom-Richardson grado:. Architectural score: 3/3. Nuclear score: 2/3. Mitotic score: 1/3. In situ component: Not identified. Pre Skin involvement Not. identified.  Microcalcifications: Present and associated with invasive carcinoma. Surgical Margin Status: Deap surgical margin free of tumor by 2.5 cm as measured grossly.. Lymph Node Status: Total number of lymph nodes received: 12.. Total number of lymph nodes containing mstastatic carcinoma: Size of largost metastasis: 2.5 cm. Extracapsuiar extension of tumor: Present.. "Other: I. pTNm stage: pT3 N2. Electronic Signature: Clinical history: Preoperative Diagnosis: Right MET Postoperative Dlagnosi: Symptoms/Radiologic Findings: SPECIMENS: Riaht breast and axillary contents. at Gross Description: The specimen is recaived right breast and axillary contents the specimen consists of a portion of fibroadipose breast tissue and overtying skin that measure s 18.0 by 8.0 cn and weighs 1,529 gm. The skin surfaca measures 23.0 x 13.8 cm is light tan wrinkled there is a scar within the outer quadrant measuring 3.0 cm that is 9.2 cm in the nippl. there is slight ecchymosis noted within the upper outer quadrant. No other lesions are identified. The nipple is eccontrically placed that is contrally located it is within 2.5 cm of the dep margin of resection the surrounding breast tissue reveals yellow-tan fatty fibroadipose ssue with portion of axillary contents m asuring 10.0x6.0x3.0 cm there ar sectloning cu 17 and the blue one addition eled-18. Ropresentative sections are submitted in cas tes labeled rom the mass node trisected- block 16-18: One probable node bisected 1cs-0-3 Carciom plomorphic 8oxx/3 (inVasi< /obuar) Sip : brest. c50.9 lw 10/3/1
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diff --git a/output/text/15bd95db-0428-4ef7-8bbe-4f8813ead9a1.txt b/output/text/15bd95db-0428-4ef7-8bbe-4f8813ead9a1.txt
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index 0000000000000000000000000000000000000000..59e10b545231f78f219ca1b60290937a23919ab7
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+UUID:B327B015-3D3E-400C-A172-8144085F6359 TCGA-DK-A6AV-01A-PR Redacted SURGICAL PATHOLOGY REPORT * Addendum * Patient Name: Accession #: Med. Rec. #: Date of Procedure: DOB: Age Location: Date of Receipt: Gender: Service: Date of Report: Ref. Physician: Account #: Patient Address: Billing Type: Additional Copy to: Ref. Source: Clinical Diagnosis & History: 1. T1/ Tis bladder cancer.. Specimens Submitted: 1: Bladder, bilateral tubes and ovaries and uterus, radical cystectomy, hysterectomy, and bilateral salpingo-oophorectomy 2: Lymph nodes, left pelvic, resection. 3: Lymph nodes, right pelvic, resection. 4:  Round ligament, right, excision Round ligament, left, excision ' 6: Soft tissue, perivesicle, excision 7: Ureter, distal left, segmental resection. 8: Ureter, distal right, segmental resection. DIAGNOSIS:  Bladder, bilateral tubes and ovaries and uterus, radical cystectomy, hysterectomy, and bilateral. salpingo-oophorectomy: Tumor Type: Invasive urothelial carcinoma, NOS Histologic Grade: High grade Pattern of growth of the Non-Invasive component:  Papillary and flat Pattern of growth of the Invasive component:  Infiltrating Tumor Multicentricity: zaD-O-3 Identified arenoms wrstheQiaL NSS Bladder Local Invasion: 8/qo/3  Superficial half of muscularis propria. cecF Extravesical Tumor Extension: Site. Kome y blasde Ce7! Right ureter uninvolved Left ureter involved PIK L  Urethra uninvolved YBlasloly NOS c479 Vascular Invasion: Not identified QO 4)1e/I3 Perineural Invasion: Not identified Page 1 of 6
+
+--- Page 2 ---
+SUrGICAL PATHOLOgy REPORt Surgical Margins: Free of tumor Non-Neoplastic Mucosa: Exhibiting ulceration Exhibiting foreign body reaction. Exhibiting proliferative cystitis (Brunn's nests, cystitis cystica, cystitis glandularis). Female Genital Organs: The endometrium shows atrophy The right fallopian tube shows a focal nodular epithelial proliferation (see comment). The left ovary shows simple serous cyst  Remaining genital organs are unremarkable. Perivesical Lymph Nodes: LN Not involved 1 The Pathologic Stage is (AJCC 2002): pT2a (Invades superficial half of muscularis propria). Comment: Based on the initial immunohistochemical evaluation, the approximately 2 mm nodule is consistent with a primary  mullerian-derived glandular lesion, and not metastatic urothelial carcinoma. Further studies are being performed to better characterize it, and the results will be issued in an addendum report. 2. Lymph nodes, left pelvic, resection: Lymph Nodes: Not involved Number of nodes examined:3 Lymph nodes, right pelvic, resection: 3 Lymph Nodes: Not involved Number of nodes examined:9 4. Round ligament, right, resection: Benign segment of round ligament 5. Round ligament, left, resection: Benign segment of round ligament 6. Soft tissue, perivesical, resection:. Benign adipose tissue. 7. Ureter, left distal, resection: Benign segment of ureter 8. Ureter, right distal, resection: .  Benigrf segmsntaf uretet. / ! ti.c.. REVIEWED AND APPRQVED,THIS REPORT. Special Studies: Result Special Stain Comment WT1  Page 2 of 6
+
+--- Page 3 ---
+SURGICAL PATHOLOGY REPORT P53 4A4/P63 34BE12 P53 IMM RECUT NEG CONT IMM RECUT NEG CONT MIB-1 (Ki-67) CK5/6  D2-40 ER-C PR-C EMA CALR INHibin GFAP RECUT Gross Description: 1.) The specimen is received fresh, labeled "bladder, urethra, urachus, perivesical tissue, uterus, bilateral tubes and ovaries and anterior vaginal wall'. It consist of a bladder, urethra, urachus, perivesical tissue, uterus, bilateral tubes and ovaries and anterior vaginal wall measuring 10.5 cm from superior to inferior, 15.0 cm laterally and 14.0 cm from anterior to posterior. The bladder measures 9 x 8.5 x 4.2 cm, the uterus measures 5.5 x 3.2 x 1.5 cm, the right ovary measures 2.0 x 1.1 x 0.6 cm, the right fallopian tube measures 10.5 x 0.3 x 0.3 cm, the left ovary measures 2.2 x 1.2 x 1.0 cm, and the left fallopian tube measures 9.8 x 0.2 x 0.2 cm. The portion of vaginal cuff measures 7.1 x 4.0 x 0.2 cm. The distal urethral margin and the vaginal cuff margin are shaved and submitted. The ureteric stumps measure 4.0 cm and are unremarkable. The specimen is inked black and the bladder is opened anteriorly to reveal: Mass #1 --  In the right lateral wall, is a 1.7 x 0.7 x 0.2 cm soft, ulcerated, ovoid tan-brown mass, located 2.5 cm from the left  ureteric orifice and 0.2 cm from the right ureteric orifices. On sectioning, the tumor extends into but not through the muscularis. propria, to a depth of 0.2 cm, 0.6 cm away from the deep margin.. Mass #2 --  In the right posterior dome, is a 1.5 x 1.1 x 0.6 cm, soft, ulcerated, irregular bordered, tan-brown mass, located 0.3 cm from the left ureteric orifice and 0.7 cm from the right ureteric orifices. On sectioning, the tumor extends into but not through the muscularis propria, to a depth of 0.6 cm, 1.2 cm away from the deep margin.. Mass #3 --  In the left posterior dome, is a 0.9 x 0.8 x 0.6 cm, rubbery, pedunculated tan-brown mass, located 2.3 cm from the left  ureteric orifice and 4.0 cm from the right ureteric orifices. On sectioning, the tumor appears to abut the muscularis propria and is 2.0 cm away from the deep margin. A portion of this mass has been submitted to TPS. Mass #4 -- In the left lateral wall, is a 0.3 x 0.2 x 0.1 cm firm, round, tan-brown, papilliferous mass, located 2.5 cm from the left  ureteric orifice and 4.2 cm from the right ureteric orifices. On sectioning, the tumor appears to remain confined to mucosa and is 2.0 cm away from the deep margin. Mass #5 -- In the lower left anteriolateral wall, abutting the trigone, is a 2.1 x 1.5 x 1.0 cm firm, centrally ulcerated, bosselated- bordered sessile, tan-brown mass, located 0.4 cm from the left ureteric orifice and 2.6 cm from the right ureteric orifices. On  sectioning, the tumor extends into but not through the muscularis propria, to a depth of 0.7 cm and is 1.0 cm away from the deep margin. In addition, located in the right lateral wall, is a 2.0 x 2.0 x 1.1 cm diverticula. The remaining bladder mucosa is edematous and congested. A possible discrete perivesical lymph node is identified and entirely submitted. The uterus is bivalved to reveal a roughly triangular endometrial cavity containing a flat, tan endometrium. The myometrium is smooth, tan-white and has two, E. rubbery, round tan-white mural nodules with smooth white cut surfaces, both averaging 0.4 cm in greatest dimension. The left ovary is bisected to reveal a 1.5 x 1.1 x 0.8 cm unilocular, thin-walled, clear fluid filled cysts with a smooth tan-white inner lining. The right ovary and bilateral fallopian tubes are unremarkable. Tissue is submitted for TPs. Gross potographs are taken. Representative sections are submitted. Summary of sections:  A UM - urethral margin  Page 3 of 6
+
+--- Page 4 ---
+SURGICAL PATHOLOGY REPORT RUM - right ureter margin LUM -left ureter margin M1 -- mass #1 M2 - mass #2 M3 -- mass #3  M4 -- mass #4 M5 -- mass #5 D - diverticula RUO -right ureteric orifice LUO -left ureteric orifice. LP-left posterior wall LA -left anterior wall RP-right posterior wall RA -right anterior wall GONE -trigone DOME -dome F -perivesical fat U -- possible urachus EMM-endomyometrium CX-cervix DVM -distal vaginal margin RFO-right tube and ovary LFO-left tube and ovary LN -- possible lymph node 2.) The specimen is received fresh, labeled "Left pelvic lymph nodes" and consists of a 5.3 x 8 x 1.1 cm aggregate of soft,  Iobulated yellow-red adipose. Sectioning reveals three rubbery tan-pink lymph nodes ranging from 1.5 to 4.5 cm in greatest. dimension. The smaller lymph nodes are bisected and entirely submitted. The largest lymph node is bisected, cut in half and. entirely submitted. Summary of sections: BLN -- bisected lymph nodes 3.) The specimen is received fresh, labeled "Right pelvic lymph nodes" and consists of a 7.0 x 3.0 x 0.5 cm aggregate of soft, lobulated yellow-red adipose.  Sectioning reveals five rubbery tan-pink lymph nodes ranging from 0.9 to 3.1 cm in greatest  dimension. The two thickest lymph nodes are bisected. All lymph nodes are entirely submitted.. Summary of sections: LN -- lymph nodes BLN -- bisected lymph nodes 4). The specimen is received in formalin labeled, "right round ligament", and consists of a segment of tan soft tissue measuring 0.9 x 0.4 x 0.4 cm.Entirely submitted. Summary of sections: U---undesignated 5). The specimen is received in formalin labeled, "left round ligament", and consists of a segment of tan soft tissue measuring 2.5 x 1.0 x 1.0 cm. Entirely submitted. Summary of sections: U-- undesignated 6). The specimen is received in formalin labeled, "perivesicle fat", and consists of multiple pieces of fibroadipose tissue measuring 3.0 x 2.0 x 0.3 cm in aggregate.Entirely submitted. Page 4 of 6
+
+--- Page 5 ---
+SURGICAL PATHOLOGY REPORT Summary of sections: U-- undesignated 7). The specimen is received in formalin labeled, "distal left ureter", and consists of a segment of tan tissue measuring 0.4 cm in greatest dimension.Entirely submitted. Summary of sections: U-- undesignated- 8). The specimen is received in formalin labeled, "distal right ureter clip marks proximal margin", and consists of a ureter measuring 1.0 cm in length and 0.3 cm in diameter. The proximal margin is marked with a metal clip.  The metal clip is removed and the specimen is entirely submitted. Summary of sections: P -- proximal margin M -- middle segment D -- distal margin Summary of Sections: Part 1:  Bladder, bilateral tubes and ovaries and uterus, radical cystectomy, hysterectomy, and bilateral.  salpingo-oophorectomy Block Sect. Site PCs 1 cX 1 1 D 1 1 DOME 1 1 DVM 1 EMM 1 F 1 1 GONE 1 LA 1 1 LN 1 1 LO 1 1 LP 1 3 LT 3 1 LUM 1 1 LUO 1 2 m1 2 1  M2 1 1 M3 1 2 m4 2 2 M5 2 1 RA 1 1 RO 1 1 RP 1 3 RT 3 1 RUM 1 1 RUO 1 1 U 1 1 UM 1 N: vag 2 Part 2:Lymph nodes, left pelvic, resection Block Sect. Site PCs 3 BLN 3 Part 3:Lymph nodes, right pelvic, resection. Page 5 of 6
+
+--- Page 6 ---
+SURGICAL PATHOLOGY REPORT Sect. Site PCs Block 2 BLN 2 3 LN 3 Part 4:  SP: Round ligament, right, excision Block Sect. Site PCs 1 U 1 Part 5:  SP: Round ligament, left, excision Block Sect. Site PCs 1 U 1 Part 6:  SP: Soft tissue, perivesicle, excision Block Sect. Site PCs 1 U 1 Part 7:SP: Ureter, distal left, segmental resection. Block Sect. Site PCs 1 U 1 Part 8:SP: Ureter, distal right, segmental resection. Block Sect. Site PCs 1 D 1 1 m 1 1 P 1 Procedures/Addenda: Date Ordered: Status: Signed Out Addendum Date Complete: Date Reported: Addendum Diagnosis #1 On immunohistochemical staining, the incidental fallopian tube lesion expresses ER, EMA and wT-1, whereas it is negative for PR, calretinin, keratin 5/6, p53, p63, 34BE12 and D2-40. The proliferative rate with Ki-67 stain is low (<5%). Inhibin and GFAP  immunostains were also performed, but the lesion was no longer present in the slides stained. These results support fallopian tube  epithelial differentiation. The fallopian tubes were entirely submitted for histologic examination and additional abnormalities are not identified. The lesion is, therefore, best considered a focus of epithelial hyperplasia.. who concurs. Representative slides were also This part of the specimen was reviewed in consultation with Dr.. reviewed at the daily intradepartmental pathology consensus conference.. Signed out by 5913 umor Site Case is (circle):  Page 6 of 6 END OF REPORT
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+UUID: 3E8F2012-A457-4358-9C8B-23292374A743 TCGA-AN-A0AT-01A-PRE Redacted TSS Patient ID Case #: JOB: Sex: Female Ethnicity (Race):. Cancer Samplea Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma Date of Procurement:. Anatomic Site: Right Breast Tumor location: Primary Tissue Specification: Tumor Specimen Matrix: Tissue Specimen Format: Frozen Container: cryomold Type of Procurement: Radical mastectomy Grade: 3 T Stage: 2 N Stage: 0 M Stage: 0 Treatment: none Treatment Details: n/a Normal Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw Matrix: Blood Specimen Format: frozen Container: tube Date of Procurement:. 1cs-0-3 cortinoma,inifiHtratnq duct,Nos 850cf3 lw Site: brast, nos C5o.9. 10/211
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diff --git a/output/text/16127d41-5d69-4ba4-bb3b-d38bebfe911e.txt b/output/text/16127d41-5d69-4ba4-bb3b-d38bebfe911e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5003eec85d614f3c7e876750b39d60ad06a41993
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+Jcs-0-3 Caceioma, mfiltnatny lobular,NOS 852013 1|8f10 lu Path Sire: bruast,Nss. CQcF C5o!q TSS UUID:7E0F430B-B96B-49B1-B4C1-88C1F3A855A7 SPECIMENS: TCGA-E2-A14U-01A-PR Redacted A. SENTINEL LYMPH NODES #1 & #2 B. SENTINEL LYMPH NODE #3 C. SENTINEL LYMPH NODES #4 & #5 D. SENTINEL LYMPH NODE #6 E. RiGHT BREAST WLE NEEDLE LOCALIZATION F. SENTINEL LYMPH NODE #7 SPECIMEN(S): A. SENTINEL LYMPH NODES #1 & #2 B. SENTINEL LYMPH NODE #3 C. SENTINEL LYMPH NODES #4 & #5 D. SENTINEL LYMPH NODE #6 E. RIGHT BREAST WLE NEEDLE LOCALIZATION F. SENTINEL LYMPH NODE #7 INTRAOPERATIVE CONSULTATION DIAGNOSIS: TPA1/TPA2/TPB/TPC1rPr:2/TPC3/TPD/TPF-SLN # 1&3/SI N #3/SLN #4&5/SLN #6/ SLN #7: No tumor cells seen called by Dr. to Dr. at n{A}., C-right breast wide local excision needle localization: Tumor is 1.7 cm located 1.3 cm from the nearest/lateral margin {B,C}, n.{D}, {E,F}. called by Dr to Dr. at Gross DescriptiOn: A. SENTINEL LYMPH NODE #1 &2  Received fresh are two lymph nodes measuring 0.5 x 0.4 x 0.2 cm and 0.4 x 0.3 x 0.2 cm. Two touch preps are performed and 2 lymph nodes are submitted in cassettes A1-A2. B. SLN #3  Received fresh is a lymph node measuring 0.2 x 0.2 x 0.2 cm. One touch prep is performed and the lymph node is submitted in cassette B1. C. SLN #4 & 5 Received fresh are 3 lymph nodes each, 0.2 x 0.2 x 0 .2 cm; 3 touch preps are performed and the lymph node is submitted separately in cassettes C1-C3. D. SLN #6  Received fresh is a lymph node measuring 0.3 x 0.2 x 0.2 cm. One touch prep performed and the lymph node is submitted entirely in cassette D1. E. RIGHT BREAST WIDE LOCAL EXCISION NEEDLE LOCALIZATION  Received fresh is an oriented (single-anterior, double-lateral, triple-superior.) 78 g, 5.5 x 4.5 x 5 cm needle localized Iumpectomy with radiograph. Ink code: anterior-blue, posterior-black, superior-red, inferior-orange, medial-green, Iateral-yellow. Specimen is serially sectioned into 5 slices revealing a 2.3 x 1.7 x 1.5 cm firm stellate tan mass that is closest to the lateral margin at 1.3 cm. Tissue is procured. 80% of the specimen is submitted as follows:. E1-E3: mid lateral margin, perpendicular sections E4: slice 2, mid E5: slice 2, mid posterior E6: slice 3, superior anterior E7: slice 3, inferior anterior E8: slice 3, mid superior anterior E9: slice 3, mid inferior anterior E10: slice 3, mid superior posterior E11: slice 3, mid inferior posterior{mass} E12: slice 3, superior posterior E13: slice 3, inferior posterior E14: slice 4, superior anterior E15: slice 4, inferior anterior E16: slice 4, mid anterior/superior E17: slice 4, mid inferior anterior E18: slice 4, mid superior posterior E19: slice 4, mid posterior inferior E20: slice 4, superior posterior E21: slice 4, mid posterior E22: slice 4, inferior posterior. E23-E28: portion of medial margin, perpendicular sections F. SLN #7
+
+--- Page 2 ---
+Received fresh is a lymph node measuring 0.5 x 0.4 x 0.3 cm. One touch prep is performed the lymph node is submitted entirely in cassette F1.. DIAGNOSIS: A. LYMPH NODES, SENTINEL #1 AND #2, EXCISION: - TWO LYMPH NODES, NEGATIVE FOR METASTASES (0/2) - AE 1/3 NEGATIVE B. LYMPH NODE, SENTINEL #3, EXCISION:E - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1) - AE 1/3 NEGATIVE. C. LYMPH NODES, SENTINEL #4 AND #5, EXCISION: - THREE LYMPH NODES, NEGATIVE FOR METASTASES (0/3) - AE 1/3 NEGATIVE. D. LYMPH NODE, SENTINEL #6, EXCISION:E - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1) - AE 1/3 NEGATIVE E. BREAST, RIGHT, WIDE LOCAL EXCISION WITH NEEDLE LOCALIZATION: - INVASIVE LOBULAR CARCINOMA, SBR 2, MEASURING 1.8-CM OBULAR CARCINOMA IN SITUE - FOCAL ATYPICAL DUCTAL HYPERPLASIA - SURGICAL RESECTION MARGINS NEGATIVE FOR TUMOR - SEE SYNOPTIC REPORT AND SEE NOTE F. LYMPH NODE, SENTINEL #7, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1) - AE 1/3 NEGATIVE. NOTE: Invasive lobular carcinoma is identified. The tumor measured on two contiguous sections (slides #E16 and. E18) (1.8-cm). A satelite invasive tumor is identified, 0.5-cm from the main mass, measuring 1 mm (slide #E16). SYNOPTIC REPORT - BREASTE Specimen Type: Excision Yes - For mass Needle Localization: Laterality: Right Invasive Tumor Present Multifocality: No WHO CLASSIFICATION Invasive lobular carcinoma 8520/3 Tumor size: 1.8cm Tumor Site: Upper outer quadrant Margins: Negative Tubular Score: 3 Nuclear Grade: 2 Mitotic Score:1 Modified Scarff Bloom Richardson Grade:. 2 Necrosis: Absent Vascular/Lymphatic Invasion:e None identified Lobular neoplasia: LCIS Lymph nodes: Sentinel lymph node only Negative 0/8 Lymph node status: DCIS not present ER/PR/HER2 Results ER: Positive PR: Positive HER2: Pending by FISH pT 1c N 0 Pathological staging (pTN): SYNOPTIC REPORT - BREAST, ER/PR RESULTS
+
+--- Page 3 ---
+Specimen: Surgical Excision Block Number: E18 ER: Positive Allred Score: 8 = Proportion Score 5 + Intensity Score 3 PR: Positive Allred Score: 8 = Proportion Score 5 + Intensity Score 3 COMMENT: The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring range from 0 to 8. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2. METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Immunohistochemistry was performed using the mouse anti-human ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) provided by Dako  ollowing the manufacturer s instructions. This assay was not modified. Interpretation of the ER/PR immunomsws..emical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal review of staining performance. SYNOPTIC REPORT - BREAST HER-2 RESULTS Specimen: Surgical Excision Block Number: E18 Interpretation: EQUIvOCAL Intensity: 2+ % Tumor Staining: 40% Fish Ordered: Yes , on Date METHODOLOGY:  Tissue was fixed in 10% neutral buffered formalin for no less than 8 and nn Ionaer than 24 hours. Her2 analysis was performed using the FDA approved Dako HercepTest (TM) test L. I using rabbit anti- human HER2. This assay was not modified. External kit-slides proviaed oy the manufacturer (cell lines with high,. Iow and negative HER2 protein expression) and in-house known HER2 amplified control tissue were evaluated along with the test tissue. Adequate, well preserved, clear-cut invasive carcinoma was identified for HER2 evaluation. Interpretation of the HER2 immunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal review of staining performance. This assay has been validated according to the 2007 joint recommendations and guidelines from AScO and CAP and from the NCCN HER2 testing in Breast Cancer Task Force. The Pathology Department takes full responsibility for this test's performance.. CLINICAL HISTORY: -year-old female with abnormal mammogram. The right breast upper outer quadrant 2.5-cm Mass appeared biopsy invasive lobular carcinoma.. PRE-OPERATIVE DIAGNOSIS: Right breast cancer INTRAOPERATIVE CONSULTATION DIAGNOSIS: E -- right breast wide local excision needle localization: Tumor is 1.7 cm located 1.3 cm from the nearest/lateral margin called by Dr to Dr. at ADDENDUM: The purpose of this addendum is to correct a typo found in the intraoperative consultation diagnosis area above reporting the results of the gross examination for the right breast wide local excision needle localization specimen and is as follows: PathVysion HER-2 DNA Probe Kit Case No Analytical Interpretation of Results: HER-2 NOT AMPLIFIED Clinical Interpretation of results Amplification of the HER-2 gene was evaluated with interphase fluorescence in-situ  hybridization (FISH) on formalin-fixed paraffin embedded tissue sections using a chromosome 17 centromeric probe and a HER-2 probe that spans the entire HER-2 gene in the by Dr. A majority of tumors cells displayed 2 chromosome 17 signals and 2 HER-2 signals, with a HER-2/CEP 17 Ratio </=2.0, consistent with no amplification of the HER2/neu gene. Block used E18 Source of case:
+
+--- Page 4 ---
+Tissue fixation formalin-fixed tissueOutside Case No: NA Tissue source breast Results interpreted: yes HER2/CEP17 ratio: 1.04 This ratio is derived by dividing the total number of LSI HER-2/neu signals by the total number of. CEP17 signals in at least 20 interphase nuclei with nonoverlapping nuclei in the neoplastic. mammary epithelial cells. Cells with no signals or with signals of only one color are disregarded. Method of ratio enumeration: manual count Limitations The Vysis PathVysion Kit is not intended for use to screen for or diagnose breast cancer. It is. intended to be used as an adjunct to other prognostic factors currently used to predict disease-free  and overall survival in stage Il, node-positive breast cancer patients. In making decisions regarding adjuvant CAF treatment, all other available clinical information should also be taken into. consideration, such as tumor size, number of involved lymph nodes, and steroid receptor status. No treatment decision for stage II, node-positive breast cancer patients should be based on HER-2/neu gene amplification status alone Overview of this test FDA APPROVED REAGENT PathVysion HER-2 DNA Probe Kit is FDA approved for selection of patients for whom Herceptin theraoy is beina considered. These tests were performed in the  under the direction ot Dr. The results of these studies should always be interpreted in the context of the. clinical, morphological, and immunophenotypic diagnosis. ONCOTYPE DX BREAST CANCER ASSAY RESULTS: Recurrence Score: 9 CLINICAL EXPERIENCE: Patients with a recurrence score of: 9 in the clinical validation study had an average rate of Distant Recurrence at 10 years of 6% ER Score: 11.3Positive PR Score: 8.3Positive Her2 Score: 10 Negative Interpretation: Negative < 6.5 Positive >= 6.5 PRNegative<5.5 Positive >= 5.5 Her2 Negative <10.7 Positive >=11.5 Equivocal = 10.7 - 11.4 See separate report for further information. Test performed at: Gross Dictation: Pathologist, 1  Microscopic/Diagnostic Dictatiun: Patnoloaist Final Review: Patholoaist.. Final: Pathologist, 1 Addendum Review: Pathologist, Addendum Final: Patholoaist. Addendum: Pathologist, Addendum Final: Pathologist, Addendum: Pathologist, ( Addendum Final: Patholoy.st
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diff --git a/output/text/16880b6b-01c4-4e5c-bea7-69aafde63eec.txt b/output/text/16880b6b-01c4-4e5c-bea7-69aafde63eec.txt
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index 0000000000000000000000000000000000000000..8d441ebea72a93df11f19059618ff779e5398b81
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+JcD-0-3 Carcinoma, infiltrat'ag cluctel, Nos 850s/3 PsH Sit: brsst uOQ C50.4 1/35/1 CQef Srh: busst,sos c50.9 Diagnosis: Poorly differentiated invasive ductal carcinoma (tumor diameter: 3.0 cm) Concluding tumor classification: NOS, G IlI, pT2LOvoR0. UUID:F24A752C-1AAE-4C70-B6D4-DD0E8C89D9AA TCGA-A8-A07B-01A-PR Redacted
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diff --git a/output/text/16cbac40-6091-46b9-8bd8-6b12f5198dcd.txt b/output/text/16cbac40-6091-46b9-8bd8-6b12f5198dcd.txt
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+
+--- Page 1 ---
+BREAST TISSUE CHECKLIST m Specimen type: Mastectomy Specimen size: Not specified Opmp Tumor site: Breast Tumor size: 2.2 x 1.5 x 5 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinoma Histologic grade: Tumor extent: Not specified Lymph nodes: 3/5 positive for metastasis (Axillary 3/5) 50N yorn9 ixy!S Extracapsular invasion of the lymph nodes: Not specified [Left) upper m Margins: Not specified inner -0-y/ quadrant Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified. Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified. Additional pathologic findings: Not specified Comments... None.
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diff --git a/output/text/16e1ae3e-5438-48aa-9ce6-7d57fae5b5fe.txt b/output/text/16e1ae3e-5438-48aa-9ce6-7d57fae5b5fe.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0c06c828e68c4518784161b79389ce4e4426274a
--- /dev/null
+++ b/output/text/16e1ae3e-5438-48aa-9ce6-7d57fae5b5fe.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+Clinical Diagnosis & History: year old female with 2.7 cm right breast cancer, lower outer quadrant and FNA (+)'metastatic right lymph node. Specimens Submitted: 1: sp: Right breast and axillary contents levels one and two with tags attached 2: sp: Subscapular nodes, right axilla level one DIAGNOSIS: 1. BREAST, RIGHT; MASTECTOMY AND AXILLARY DISSECTION: - INVASIVE DUCTAL CARCINOMA, MIXED MUCINOUS & NOS TYPE AND WITH SOLID-PAPILLARY FEATURES, HISTOLOGIC GRADE III/III (SLIGHT OR NO TUBULE FORMATION), NUCLEAR GRADE II/III (MODERATE VARIATION IN SIZE AND SHAPE), MEASURING 2.3 CM IN LARGEST DIMENSION MICROSCOPICALLY. UUID: 3671D46F-6069-420A-9830-24F67E888086 - (DCIS) IS ALSO IDENTIFIED, SOLID AND CRIBRIFORM TYPES WITH TCGA-AO-A03G-01A-PR INTERMEDIATE NUCLEAR GRADE  Redacted AND MINIMAL NECROSIS. - LOBULAR INVOLVEMENT BY DCIS IS PRESENT. - THE DCIS CONSTITUTES LESS THAN OR EQUAL TO 25% OF THE TOTAL TUMOR MASS, AND IS PRESENT ADMIXBD WITH AND AWAY FROM THE INVASIVE COMPONENT - THE INVASIVE CARCINOMA IS LOCATED IN THE LOWER OUTER QUADRANT THE DCIS IS LOCATED IN THE LOWER OUTER QUADRANT AND LOWER INNER QUADRANT - NO INVOLVEMENT OF THE NIPPLE BY EITHER IN SITU OR INVASIVE CARCINOMA IS IDENTIFIED. - CALCIFICATIONS ARE PRESENT IN BENIGN BREAST PARENCHYMA.S - VASCULAR INVASION IS PRESENT. - INVASIVE CARCINOMA IS CLOSE (LESS THAN OR EQUAL TO 1 MM) TO THE) FOLLOWING SURGICAL MARGIN(S) : BLUE INKED MARGIN (ANTERIOR). - NO SKIN INVOLVEMENT BY CARCINOMA IS IDENTIFIED. - THE NON-NEOPLASTIC BREAST TISSUE SHOWS BIOPSY SITE CHANGES AND PROLIFERATIVE FIBROCYSTIC LEVEL 1: METASTATIC ADENOCARCINOMA TO FOUR OUT OF TEN LYMPH NODES  CHANGES INCLUDING INTRADUCTAL PAPILLOMA. (4/10) THE LARGEST METASTATIC FOCUS MEASURES 2.5 CM THERE IS EXTRANODAL BXTENSION OF CARCINOMA, FOCAL. - LEVEL 2 : THREE BENIGN LYMPH NODES (0/3) 1c0-0-3 ** Continued on next page ** Site: brist, Nos C- SD.9 8523/3 1c/22/u
+
+--- Page 2 ---
+IMMUNOHISTOCHEMICAL STAIN WAS PERFORMED ON FORMALIN-FIXED TISSUE WITH THE age HER2 NEGATIVE (0 / 1+) 5% OF INVASIVE TUMOR CELLS EXHIBIT COMPLETE MEMBRANOUS STAINING; UNIFORMITY OF STAINING: ABSENT HOMOGENEOUS, DARK CIRCUMFERENTIAL PATTERN: ABSENT Comnent: Controls are satisfactory. s PATHWAY anti-HER-2/neu is an the internal domain of the c-erbb-2 oncoprotein (Her2) for. immunohistochemical detection of HeR2 protein overexpression in breast cancer tissue routinely processed for histologic evaluation. The HBR2 test results are reported in accordance with the Asco/cap guidelina recommendations for Her2 testing in breast cancer (J clin Oncol 2007; 25(1) :118-145). The BR and pR rabbit monoclonal antibodies are also FDA. approved. 2. LYMPH NODES, RIGHT AXILLA LEVEL ONE, SUBCAPSULAR: - SIX BENIGN LYMPH NODES (0/6). Some of the immunohistochemistry and performance characteristics were determined by tests were devaloned and their They have not been cleared or approved by the Us Food and Drug Administration. The FoA has datermined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of i98s (cLIa : 88) as qualified to perform high complexity clinical laboratory testing. 2. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL BXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL). AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. *** Report Blectronicaily Signed Out *** Gross Descriotion: 1).The specimen is received fresh labeled, "right breast and axillary contents levels one and two with tags attached" and consists of a breast measuring 19 x 18 x 3 cm with overlying skin ellipse measuring 11 x 3 cm. Situated centrally on the skin surface is an everted nipple measuring 1 x 1 x 0.6 cm and areola measuring 3 x 3 cm. A suture demarcates the axillary contents which measures 11 x 7 x 3 cm. Two tags are present, designating levels one and two. The posterior surface of the breast is inked black, the anterior blue and the axiilary aspect is inked yellow. The specimen is serially sectioned to reveal a 2.5 cm diameter mass in the lower outer ** Continued on next page **.
+
+--- Page 3 ---
+quadrant  and 1 cm from the deep margin.. The remaining breast tissue shows nodular fibroadipose tissue. A clip is identified in the mass. tissue is dissected to reveal multiple lymph nodes, ranging in size from 0.5 * The axillary Cm to 2.5 cm. Representative sections are submitted. nodes are entirely submitted.. All dissected lymph Summary of sections:. N - nipple NB - nipple base D - deep margin - tumor UIQ upper inner quadrant LIQ lower inner  quadrant UOQ - upper outer quadrant LOQ lower : outer quadrant L1 lymph nodes, level 1 L2 lymph nodes level2 2). The specimen is received in formalin, labeled "subscapular nodes right axilla level one" and consists of pink tan firm lymph nodes ranging from 0.8 to up 2 cm in greatest dimension..  All identified lymph nodes are submitted.. Summary of sections:. LN -- lymph nodes BLN-- bisected lymph nodes 3 Summary of Sections: Part 1:  SP: Right breast and axillary contents levels one and two with tags attached Block Sect. Site pCs 1 D 6 1 L1 1 6 L2 1 LIQ 2 1 LOQ 1 2 N 1 NB 2 1 Hd T UIQ UOQ 1 1 Part 2: SP: Subscapular nodes, right axilla level one. Block Sect. Site pCs 2 BLN LN 2 1 ** Continued on next page **
+
+--- Page 4 ---
+End of Report *
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diff --git a/output/text/16f966a7-c0d3-4c64-87ad-eb8012e590d8.txt b/output/text/16f966a7-c0d3-4c64-87ad-eb8012e590d8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8786a37e9cf1ccd215cd7acafe7d57eeb9310ec1
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 197 UUID: 84CA9DDD-36CA-466E-A74C-C7FB03E7C9E4 TCGA-A2-A04W-01A-PR Redacted LOGY REPORT Patient: FMP/SSN: Specimen #: DOb/Age/Sex: (Age: Location: Race: WHITE Taken: Physician(s) : Received: Reported: **AMENDED** 1CS-0~3 SPECIMEN: Carciioma, apocrnu,nifiltruHy 8401/3 A: RIGHT BREAST AND AXILLARY CONTENTS Sih: b&aot N05 C50.9 B: ADDITIONAL RIGHT BREAST TISSUE y/2yf h FINAL DIAGNOSIS: A & B. BREAST, RIGHT, MODIFIED RADICAL MASTECTOMY WITH AXILLARY LYMPH NODES, EXCISION: TUMOR TYPE: APOCRINE CARCINOMA, INFILTRATING (A2,A3,A14,A15) (HISTIOCyToiD SUbType) (SeE COMmeNT). NOTTINGHAM GRADE: MODERATELY DIFFERENTIATED (G2) NOTTINGHAM SCORE: 7/9 (Tubules= 3, Nuclei= 3, Mitoses- 1; mitotic count 3 per 10 HpF at 40x power) TUMOR SIZE (GREATEST DIMENSION): 4.5 CM (MEASURED GROSSLY; See comment). TUMOR NECROSIS: ABSENT IN INFILTRATING COMPONENT, PRESENT (COMEDO, IN-SITU TYPE) IN DCIS MICROCALCIFICATIONS: PRESENT IN STROMA VENOUS / LYMPHATIC INVASION: PRESENT (A1O,A14) MARGINS: NEGATIVE -DISTANCE OF TUMOR FROM NEAREST MARGIN IS 1.1 CM, FROM DEEP MARGIN (A3). INTRADUCTAL COMPONENT: EXTENSIVE LYMPH NODES: ONE OF 18 POSITIVE FOR TUMOR BY IHC ONLY (SEE COMMENT). NIPPLE INVOLVEMENT: ABSENT SKIN INVOLVEMENT: ABSENT MULTICENTRICITY: ABSENT ESTROGEN RECEPTORS: NEGATIVE (PREVIOUSLY EVALUATED FROM PROGESTERONE RECEPTORS: NEGATIVE (PREVIOUSLY EVALUATED FROM HER 2 NEU by IHC: POSITIVE (3+) (PREVIOUSLY EVALUATED FROM S05-12958) PATHOLOGIC STAGE: pT2 NO(i+) MX ADDITIONAL PATHOLOGIC CHANGES: CYSTIC CHANGE, SCLEROSING ADENOSIS, (AJcc Stage II) FIBROADENOMATOID CHANGE, APOCRINE METAPLASIA COMMENT : COMMENT #2 Page 1 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 Continued on Next Page
+
+--- Page 2 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient:. Specimen #: FINAL DIAGNOSIS (continued) : This case is amended to change the lymph node assessment to the above from a prior assessment of "LYMPH NODES: 18 NEGATIVE FOR TUMOR.", and to change the stage to T2 N0(i+) frOm T2 NO. Dr lymph nodes on this patient to coilaborate with the peT findings of a requested additional evaluation of the. positive node, so the nodes in Al0, All, A12, A19 and A20 were evaluated with keratin. In Alo, the node originally showing pericapsular lymphatic involvement, the keratin shows individual cells and one subcapsular cluster of tumor cells less than 0.2 mm in diameter. Dr was informed of this change in report today by email.. ORIGINAL COMMENT:S The tumor was too large for microscopic measurement, so exact measurement is not possible. Some of the Dcis component may have been included in the gross measurement, but the bulk of tumor is infiltrative and represents at least a T2 lesion. Slide Aio contains a lymph node with lymphvascular space invasion just outside of the capsule. We are interpreting this as a negative node. This report was amended patient history listing her age incorrected as. pathologic stage was changed from N1 to No, another typographical error. years. Additionally, the ** Report Electronically Signed Out ** CLINICAL DIAGNOSIS AND HISTORY: year old female with invasive ductal carcinoma of right breast and positive for axillary lymph nodes. Presents for modified radical mastectomy. PRE-OPERATIVE DIAGNOSIS: Right breast cancer POST-OPERATIVE DIAGNOSIS: Right breast cancer GROSS DESCRIPTION: A. Received fresh consists of a 504 gram right mastectomy specimen single stitch medial and double stitch superior. Specimen measures 24 cm superior. to inferior, 21 cm medial to lateral, and 3 cm anterior to posterior. The. ightly pigmented skin ellipse measures 12 x 5 cm, centrally located Page 2. FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 Continued on Next Page
+
+--- Page 3 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: 3 GROSS DESCRIPTION (continued) : Specimen #: everted nipple measuring 1.5 x 1.5 x 1.2 cm with no discharge. No scars identified.  Superficial upper outer quadrant is inked blue and deep margin. inked black. Specimen serially sectioned to reveal fairly well circumscribed pink firm mass measuring 4.5 x 2.5 x 2.0 cm. The mass shows focal hemorrhage and lies within a bed of dense, diffusely nodular, focally necrotic fibrous tissue. The mass is located 1 cm from deep margin and 0.5 cm from blue superficial margin. Remaining tissue shows scattered cysts measuring up to 0.4 cm. Multiple indurated foci are also seen within the upper inner quadrant and~lower inner quadrant. A 0.7 cm lymph node is seen within the upper outer quadrant.. A separately received portion of axillary tail measures 10 x 3 x 1.0 cm and oriented with stitch on high end. Five lymph nodes are identified measuring 0.7 to 1.0 cm. The specimen is submitted as follows:. Al: skin A2: mass, central A3: margin A4: lateral mass A5: upper outer quadrant A6: lower outer quadrant A7: lower inner quadrant A8: upper inner quadrant A9: intramammary lymph node Al0: two high axiliary lymph nodes bisected. Al1: two mid axillary lymph nodes bisected. A12: one low axillary lymph node A13: nipple Al4-Al7: upper outer quadrant mass lateral to medial. A18: high axillary lymph node A19: middle axillary lymph node A20: low axillary lymph node. 20cr B. Received in formalin labeled with patient's name designated "RIGHT BREAST TISSUE WITH AXILLARY CONTENTS" cOnSists of a 1.0 x 1.0 x 0.4 cm piece of red and yellow soft tissue. Specimen submitted entirely in one cassette. Page 3 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 End of Report
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diff --git a/output/text/16feedc4-2044-4a7e-84ad-24bbe00f7c50.txt b/output/text/16feedc4-2044-4a7e-84ad-24bbe00f7c50.txt
new file mode 100644
index 0000000000000000000000000000000000000000..18b7ccbfaac29111ab561b0b57a2b09f3d3eae50
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Surgical Pathology TCGA-DZ-6134 REVISED REPORT (Addendum/Procedure included). TISSUE DESCRIPTION: Needle biopsies right (5 cores) and left (5 cores) lobes of the prostate, left kidney (85 grams, 8.3 x 4.6 x 4.2 cm) with 4.7 cm of ureter. DIAGNOSIS : Kidney, left, radical nephrectomy:  Grade 1 (of 4) renal ce1l located in the lower pole.* The tumor is confined to the kidney. The renal vein is grossly free of tumor. The tumor does not involve the collecting system. Coagulative tumor necrosis is absent. Sarcomatoid differentiation is absent. No renal hilar lymph nodes are identified. The adrenal gland is absent. The surgical margins are negative for tumor. The background kidney shows significant chronic changes with marked interstitial fibrosis and tubule atrophy consistent with chronic pyelonephritis. Multiple (4) stones are present within renal cysts (0.2 cm to 0.4 cm in greatest dimension). Case seen in consultation with. Prostate, right, needle biopsies: Adenocarcinoma y(gleason 3 + 3) involving 5% of the specimen.. Prostate, left, needle biopsies: Benign prostatic tissue.. ADDENDUM: The cancer cells in the prostate, right, needle biopsy (A2) are DNA diploid. Proliferation index (mib-I) = 5.569%. This represents an intermediate value (low: 0.0% to <5.0%, intermediate: 5.0% to <10.0%, or high: >/- 10.0%). Intermediate and high Mib-I values are associated with an increased risk of cancer progression following prostatectomy even after adjusting for statistically significant prostate needle biopsy. features PRELIMINARY FROZEN SECTION CONSULTATION: HOLD for permanent sections of the prostate needle biopsies.
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diff --git a/output/text/1714a118-bdf0-4368-8ca0-465c02effe75.txt b/output/text/1714a118-bdf0-4368-8ca0-465c02effe75.txt
new file mode 100644
index 0000000000000000000000000000000000000000..15a94b9ab37d491e19ff182b1295670a36549618
--- /dev/null
+++ b/output/text/1714a118-bdf0-4368-8ca0-465c02effe75.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis This concerns a moderately differentiated colic adenocarcinoma, G2, with infiltration of all. wall layers (pT3), with vascular infiltration L1, V1, with free lymph nodes (pN0) (0/14) as well as free resection margins, corresponding to R0.. Tumor classification ICDO-DA M-8140/3 G2 pT3, L1, V1, pN0, consistent with R0 Note: The lymph nodes were relatively large enough to have been worthy of note in CTs or other. procedures involving images.
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diff --git a/output/text/171605e1-30b8-4dfe-b961-7e6a47df63da.txt b/output/text/171605e1-30b8-4dfe-b961-7e6a47df63da.txt
new file mode 100644
index 0000000000000000000000000000000000000000..156b74c78dba1d46c8b56fbaf3206ba59b971655
--- /dev/null
+++ b/output/text/171605e1-30b8-4dfe-b961-7e6a47df63da.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Patient Name Accession #: Med. Rec. #: Dale of Procedure DOB: Dato of Roceipt: Gender: Date of Report: Rof. Physician: Account #: Pallent Address: Billing Type. Additional Copy to Ref. Source: Clinical Diagnosis & History: Left renat mass. Specimens Submitted: 1: Lel kidney and portion of spleen; tolal nephrectony and partial splonectomy. DIAGNOSIS: Left kidney and portlon of spleen; total nephrectomy and partial splenectomy:. Tumor Type: Renal cell carcinoma - Papillary lype Type II Histologic Grade (for urothelial carcinona): High grade Tumor Size: Grealest diameter is 4.7 cm Local Invasion (for renal cortical typos): Extends through renal capsule but confined within Gerota's fascia Ronal Vein Invasion: Not identified Surgical Margins: Free of tumor Non-Neoplastic Kidney: Focal giomerulosclerosis and vascular changes consistent with clinical history of hypertension Adrenal Gland: Not identifiod Portion of benign congested spleen adherent lo kidney, not involved by lumor Lyniph Nodes: Not identified Staging for renal cell carcinoma/oncocytoma: pT1 Tumor <= 7.0 cnt in greatest dimonsion limited to the kidney Comnent: Case reviewed a Page 1 of 2
+
+--- Page 2 ---
+1ATTEST THAT THE ABOVE OIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR QTHER MIATERIAL). AND THAT I HAVE REVIEWEDANDAPPROVEOTHISREPORT Special Studies: Result Special Stain Comment PAS Gross Description: 1. The specimen is received fresh labeled "lofl kidney and portion of spleen" and consists of the aforementioned organs with attached ureter, renat vessels and perinephric fal weighing 272.5 g in total. The kidney measures 10.6 x 5.6 x 4.6 cm. There is a 2.0 x 1.7 x 0.6 cmn fragment of grossly unremarkable spleen with a ragged surgical margin (inked blue). The attached ureter measures 4.5 cm in length and 0.3 cm in diameter. The atlached renal vein measures 0.9 cm in length and 0.8 cm in diameler. Tho renal vossels and urelor margins are grossly unremarkable. An adrenal gland is not identified. The kidney is inkod black and bivalved to reveal a 4.8 x 4.7 x 4.6 cm lobulated lesion wilh a ian yollow solid and cystic surface located in the upper pole and midporion of the kidney. This lesions breaks out inlo perinephric fat and is adherent to the fragment of spleen described above The tumor approaches wilhin 0.1 of the surgical margins but the margins are grossly negative. Seclions lhrough the kidney reveal a pink brown parenchyma. with a poorly-defined cortico-medullary junction. The cortex measures 0.9 cm and the calyces appear normal. Lymph nodes are nol identlied in the perinephric iat. Represenlative seclions are submitted for TPs and for permanent sections. A gross photograph is taken.. Summary ol sections: UVM -- ureteral and vessel margins T-- tumor including adherent spleen. THF-- tumor with hilar fat TSF -- tumor with sinus fat TK -- tumor with adjacent kidney. RP -- renat pelvis ropresontative sections K -- representative sections kidney. Summary of Sections: Part 1: Left kidney and portion of spleen; lotal nephrectomy and partial splenectomy Block Sect. Sito pCs 1 1 1 rp 1 5 5 2 thf 2 tk 2 Isf 2 1 uvm 1 Page 2 of 2 END OF REPORT
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diff --git a/output/text/171bd1d0-d2a7-461e-af61-39c04de73aa7.txt b/output/text/171bd1d0-d2a7-461e-af61-39c04de73aa7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..49db8b95cdace3fca7654af15ec0165050f08e20
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:CA6A13D4-DD80-4424-B5F3-654EE31263AE TCgA-LD-A74U-01A-Pr Redacted Surgical Pathology Report DATE OBTAINED: DATE RECEIVED: DATE REPORTED: CC: DIAGNOSIS zcD-0 3 Doleegar 1. RIght BREAST, PARTIAl MASTeCTOmy: INVaSIVE LOBULAR CARCInOMA Myleol wfsther tyyes. (gletmnphic) 85243 SIZE (INVASIVE): Approximately 70 mm; see comment ocE+BuastNsS css9 LATERALITY: Right Sute TUMOR FOCALITY: Unifocal LESIONAL SITE:  9:00 (according to operative report) HISTOLOGIC TYPE:  Invasive lobular carcinoma, classicai type, focal pleomorphic type NUCLEAR GRADE: I of II (classical type) and II-II ot II (pleomorphic type) C 56.8 HIStOLOgIC GRADE: Jsv 8/Z z|L3 N/A (invasive lobular carcinoma) IN-SITU COMPONENT: Not present LYMPH NODE SAMPLING:  Positive (11/12), (largest 45mm; with extranodal Involvement); see specimen #2 AJCC CATEGORIES: Stage III (assuming cM0" status) pTNM: pT3 pN3a cTNM: cT2 cN1 cMO INTEGRITY/ORIENTATION: Intact speclmen with deslgnated margins  MARGINS (Invasive lobular): Negatlve <0.1mm superior margin (1P, highllghted by CK7 immunostain); 0.2mm medial margin (1EE) and 1mm posterior margln (1N); other marglns >3mm LYMPHOVASCULAR INVASION: Focal suspicious for LVI MICROCALCIFICATIONS: Not identifled NIPPLE/SKIN: (if applicable) Negative skin SKELETAL MUSCLE: Not present OTHER: Focal atypical lobular hyperplasia, sclerosing adenosis, usual ductal hyperplasia,  apocrine metaplasla and prior biopsy site changes 2. RIght Axillary NOde COntents, Dissection: eLeven Out Of Twelve Lymph nOdes totalLy REpLACeD by mETaStATiC LOBuLAR CARCinOmA (11/12), LARGeSt TumOR 4.5 Cm, eXTRanODAL EXTeNSION PRESENT; ADDITIONAL INVASIVE LOBULAR CARCINOMA WITHIN THE FAT (ABOUT 2CM). 3. Omentum, resection: ADipose tissue; negatIve for tumor. ***Electronically Signed Out*** COMMENT Tumor grossly is 5.3 cm. In the axillary contents (#2), sizeable tumor mass within the fat is also present in multiple blocks, which most likely represents a direct extension from the lumpectomy, and thus the tumor size is estimated to be 7cm. 88307x2, 88305, 88329, 88342 Clinical Diagnosis and History: Right breast cancer, gastric cancer Page 1 ot 3
+
+--- Page 2 ---
+Surgical Pathology Report cT2,cN1,cM0 clinical stage II Tissue(s) Submitted: 1: RIGHT BREAST MASS SHORT SUTURE SUPERIOR LONG SUTURE LATERAL 2: RIGHT AXILLARY NODE CONTENTS 3: OMENTUM Gross Description:  Specimen #1 is received fresh for intraoperative consultation, labeled with the patient's name and right breast mass, and consists of an 11.3 cm (medial to lateral) x 8.5 cm (superior to inferior) x 4.5 cm (anterior to posterior) product of partial mastectomy which is surfaced by a 6.9 x 2.2 x 0.2 cm ellipse of unremarkable white tan skin. No nipple is identified. A short suture designating.  superior and a long suture designating lateral are present. Two needle localization wires are entering the specimen in the superior  and interior aspects. The specimen is radiographed and differentially inked as follows: superior-blue, inferior-green, lateral-yellow,. medial-red, posterior/deep-black and serially sectioned from lateral to medial into 10 slices. No biopsy clip is identified. An ill- detined, rubbery to tirm, white-tan area measuring 5.3 x 5.0 x 3.5 cm is identitied in slices 4 to 10. This area of tibrous tissue. shows some extensions to the posterior, inferior, superior, and medial margins. This fibrous area is also 2.0 cm trom the overlying. skin. No other lesions are grossly identitied. The breast parenchyma consists of tan-yellow, Iobulated adipose tissue (60%) and fibrous tissue (40%). Time in formalin: Some tumor and normal tissue is frozen for TCGA studies.. Representative sections of all slices (with the exception of slices 2 and 3) are submitted as follows: 1A-1B:  slice #1, lateral margin, perpendicular (representative). 1C-1D: slice #4, irregular fibrous area 1E: slice #4, fibrous area to posterior margin 1F:  slice #4, fibrous area to superior margin 1G-1H: slice #5, fibrous area contiguous section 1: slice #5, posterior margin 1J: slice #5, inferior and posterior margins 1K: overlying skin 1L-1M:  slice #6, contiguous section of fibrous area to inferior margin. 1N-1O: posterior margin 1P: superior margin 1Q-1T:  slice #7, contiguous section from superior to inferior (orange ink denotes contiguous section) 1U: overlying skin 1V: slice #8, fibrous area 1W: superior margin. 1X: inferior margin 1Y: posterior margin 1Z: slice #9, inferior margin 1AA: slice #9, irregular fibrous area 1BB: superior margin. 1CC: posterior margin 1DD-1GG: slice #10, medial margin, perpendicular (representative)..  Specimen #2 is received in formalin labeled right axillary dissection, and consists of 11.0 x 10.0 x 2.5 cm yellow adipose tissue. The specimen was serially sectioned to reveal 16 lymph nodes ranging in size from 1.5 to 4.5 cm. The lymph nodes are entirely submitted and labeled as follows: 2A: Two lymph nodes intact. 2B: Two lymph nodes intact. 2C: Four lymph nodes intact. 2D: One lymph node, bisected. 2E: One lymph node, bisected. 2F: One lymph node, bisected. 2G: One lymph node, bisected. 2H: One lymph node, representative section. 21: One lymph node, representative section. 2J: One lymph node, representative section. 2K-2L: One lymph node, representative section. Specimen #3 is received fresh labeled omentum, and consists of a 20 x 20 x 5.0 yellow lobulated adipose tissue. The specimen is  serially sectioned and no lesion is grossly identified. Representative sections are submitted labeled 3A-33. Page 2 of 3
+
+--- Page 3 ---
+Surgical Pathology Report Intraoperative Consult Diagnosis 1A/GDX: NEEDLE LOC WIRE ENTERS SUPERIORLY AND ONE OTHER ENTERS INFERIORLY. VAGUE AREA, NO DISCRETE MASS; MARGINS HARD TO DETERMINE; QUESTION POSTERIOR, INFERIOR, AND MEDIAL MARGIN. Pyr Tss, this i5 a mixed cartiomo 1o bulw + pleomrrphic (1o-3o?) typw. BcR b 8/2o/3 Page 3 of 3 END OF REPORT
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diff --git a/output/text/17350ba5-8204-450f-927a-ef1370432735.txt b/output/text/17350ba5-8204-450f-927a-ef1370432735.txt
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index 0000000000000000000000000000000000000000..fc6df449a1abc27e65d6f008b5f34427d2a1d595
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Redacted CLINICAL DIAGNOSIS: Hepatocellular carcinoma suggested (S6) Specimen : Liver and Liver mass. Gross Photo : GROSS: Specimen status: Fresh Operation: Right hepatectomy (Right posterior sectionectomy and segmentectomy 5) Cholecystectomy Organs: Liver (16.5 x 10.5 x 5.8 cm, 437.0 gm) Gallblaadder (7.3 cm in length, 2.8 cm in diameter, 0.5 cm in wall thickness) Lesion: A well-defined mass (4.3 x 3.7 x 3.3 cm) in right lobe. Cut surface: Yellowish tan, and granular with area of hemorrhage. Gross type: HCC: Expanding nodular Resection margin: Not involved grossly (safety margin: O.4 cm). Others: tCDO.3 Satellite nodule: No Remaining parenchyma: Cirrhotic. Representative sections submitted Qrennd, hepatocelluler N63 Gross photo: Present 8170/3 Blocks Site: Lueer CQQ.O T1-6,TB, tumor mass x 7 QO s/a0|14 L, liver parenchyma x 1 GB, gallbladder x 1 MICROSCOPIC: Hepatocellular carcinoma: Yes The worst differentiation II The major differentiation II Histologic type: Trabecular. Cell type: Hepatic Fatty change: No Fibrous capsule formation: Complete capsule. Capsular infiltration: No Septum formation: No Surgical resection margin invasion: No. Serosal invasion: No Portal vein invasion: No Microvessel invasion: No Intrahepatic metastasis: Unknown Multicentric occurrence: Unknown
+
+--- Page 2 ---
+NOT reported. Gross: Liver, right, ectomy, hepatocellular carcinoma, moderately differentiated T56000, right, P10, M81703, moderately differentiated Gallbladder, ectomy, chronic cholecystitis T57000, P10, M43005 DIAGNOSIS: Liver, right lobe, right hepatectomy: Hepatocellular carcinoma, moderately differentiated Cirrhosis, micronodular Gallbladder, cholecystectomy: Chronic cholecystitis Suggestion : lw J12[14] Diagnosis Dis HIPAA Discrepancy
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diff --git a/output/text/177fd781-869f-40b5-b122-a8b4292fb754.txt b/output/text/177fd781-869f-40b5-b122-a8b4292fb754.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9198006640ba3f0157ce4db14a50913bf9cd1fc8
--- /dev/null
+++ b/output/text/177fd781-869f-40b5-b122-a8b4292fb754.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+I0DO3 UUID:29F6869E-B06D-45DD-898D-8CEF187D0F53 TCGA-Y8-A895-01A-PR Redacted 8240|3 C44.9 Research Gross Description 1/22/13 male with right renal mass Research Dx Kidney, right, robotic assisted laparoscopic partial nephrectomy:. Papillary renal cell carcinoma, multifocal (at least 6 tumors). Please see case summary and comment. CASE SUMMARY FOR NEPHRECTOMY FOR RENAL CELL CARCINOMA: Procedure: robotic-assisted laparoscopic partial nephrectomy. Specimen laterality: right Tumor site: lower pole Tumor size: #1 largest: 6.0 cm #2-#6: 0.3 cm, 0.3 cm, 0.1 cm, 0.1 cm, <0.1 cm Tumor focality: multifocal Macroscopic extent of tumor: tumors limited to kidney Histologic type: papillary renal cell carcinoma (largest is type 1). Sarcomatoid features: not identified Tumor necrosis: not identified Histologic grade (Fuhrman Nuclear Grade): grade 2 Microscopic tumor extension: tumors limited to kidney Margins: negative for invasive carcinoma: Renal parenchymal margin: negative (closest 1mm tumor is 1 mm from margin) Renal capsular margin: negative Perinephric fat margin: negative Lymphovascular invasion: not identified Pathologic staging (pTNM): TNM descriptors: m, mutliple primary tumors Primary tumor: pT1b: Tumor more than 4 cm but not more than 7 cm in greatest dimension, limited to the kidney Regional lymph nodes: pNx: Regional lymph nodes cannot be assessed (tissue in A submitted as a lymph node has no lymph node). Number examined: 0 Number involved: 0 Distant metastasis: pM not applicable. Pathologic findings in nonneoplastic kidney: hypercellular, enlarged glomeruli, globally sclerotic glomeruli, arteriolonephrosclerosis, interstitial fibrosis and chronic inflammation Other tumors and/or tumor-like lesions: multiple smaller papillary renal cell carcinomas (as described above) AJCC Staging (7th edition) pT1b(m) pNx pM not applicable Research QC Tumor: 100% tumor nuclei 0% necrosis 0% normal Normal:
+
+--- Page 2 ---
+100% kidney Specimen Process Time Blood draw time: Plasma frozen time: Serum frozen time Buffy coat frozen time Tissue: Cold ischemia start time: Formalin fixation start time: Total cold ischemia time: Formalin fixation stop time Total formalin fixation time Specimen Weight Normal 1- 395 mg, 2- 381 mg, 3- 233 mg, 4- 385 mg Tumor 1- 398 mg, 2- 422 mg, 3- 320 mg, 4- 294 mg Specimen Size Plasma x 3 Serum x 2 Buffy coat x 1 Cryovials x 8 Normal x 4 Tumor x 4 Metastatic x 0 FFPE x 8 Norma! x 4 Tumor x 4 Metastatic x 0 Study Patient Consent Yes 6/a4(() 2
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diff --git a/output/text/179ff415-2be8-439b-8131-97de3912be25.txt b/output/text/179ff415-2be8-439b-8131-97de3912be25.txt
new file mode 100644
index 0000000000000000000000000000000000000000..87df7b807130f6ace0a237c639cb13746d9a415f
--- /dev/null
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+
+--- Page 1 ---
+page 1 / 1 Department of Cancer Pathology. copy No. Date: Examination: Histopathological examination. Internal invoice No. Value of diagnostic procedure. Examination No.: Patient: XXX PESEL: XXX Age: Gender: F Material: 1. Total organ resection -- right breast.. 1cs-0-3 Unit in charge: ' Sarcinoro mfi(trotng cluct Nos 85oo]: Physician in charge: Sthe: braot, N^oS C50.9 W 4|10/ Material collected on: Material received on: Expected time of examination: up to 8 working days. Clinical diagnosis: Cancer of the right breast, ulcerous - Toilet mastectomy. Examination performed on: Macroscopic description:e Right breast sized 13.7 x 7.6 x 4.8 cm removed without axillary tissues and with a skin flap of 17.8 x 10.2 cm. Weight 193 g. Tumour sized 6.2 x 4.3 x 7.8 cm in the middle part, 0.1 cm from the upper boundary, 0.1 cm from the base. Microscopic description: Carcinoma ductale invasivum - NHG3 (3+2+3/20 mitoses/10 HPF - visual area: 0.55mm). Infiltratio carcinomatosa cutis et musculi pectoralis.. Mamilla sine laesionibus Glandular tissue showing parenchyma atrophy.e Histopathological diagnosis:  Metastases carcinomatosae in lymphonodis axillae (No li/t). Cancer metastases of the axillary lymph nodes. (NHG3, pT4b, pN1a). Compliance validated bj Examination performed on: Results of immunohistochemical examination: Estrogen receptors found in 10-75% of neoplastic cell nuclei. Progesterone receptors found in 10-75% of neoplastic cell nuclei. HER2 protein stained with HercepTestTM by DAKO. Negative reaction in invasive cancerous cells ( Score = 0 ) Compliance valid: UUID:AA869507-1846-4812-8EC5-A4E01C588E6E TCGA-D8-A1XG-01A-PR Redacted 77
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diff --git a/output/text/17b23940-3aeb-4179-baac-43bb5d413b36.txt b/output/text/17b23940-3aeb-4179-baac-43bb5d413b36.txt
new file mode 100644
index 0000000000000000000000000000000000000000..dcd8521d948aff2d85294da0ee5967735083b4aa
--- /dev/null
+++ b/output/text/17b23940-3aeb-4179-baac-43bb5d413b36.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+1cs-0 -3 Carcn`oma, ductl mpitrath5 8500/3 C50.4 117/4 Putient: CQCF .. brtot, N1s... 050.9 Surgical Patholoey Surg Path UUID:4A86A028-C56D-455E-ASCD-47D8A34B5734 TCGA-B6-A0IM-01A-PR Redacted CLINICAL HISTORY: Not provided.. GROSS EXAMINATION: A. "Right breast mass #1", received fresh labeled with the patient's name and record number for frozen section is a 4 x 2.9 x 2.2 cm specimen with a 2 x 2 x 1.3 cm tumor. The frozen section remnant is submitted in Al. A2-A4 represent full cross sections of the tumor and adjacent tissue. B. "Right breast, long lateral short superior", received fresh is a right. mastectomy specimen weighing 2040 grams.  The skin ellipse measures 34.5 x 17.5 cm, has a 4 cm areola and a 0.9 cm nipple. A suture marks the lateral. aspect of the specimen. The breast measures 35 x 23 x 6 cm with an 8 x 6.5 x 1 cm axillary tail. In the upper outer quadrant is a recent sutured surgical incision 7 cm. The soft tissue margins are inked blue. Sectioning shows a recent biopsy cavity approximately 5 cm in diameter deep to the suture.. On contiguous with the cavity, the bulk of the tumor is more medial. This is felt to represent a single "dumbell" shaped tumor rather than two separate tumors. Maximal dimensions of this tumor are 5 x 3.5 x 3 cm. This tumor is also located in the upper lateral quadrant and is 2 cm from the deep resection margin. Further firm tissue suspicious for tumor is identified in the lateral. aspect of the biopsy cavity and measures 2 cm. Again this is 2 cm from the deep resection margin. Measuring from the medially located tumor to the lesion present at the lateral aspect of the biopsy cavity the maximum tumor diameter is 7 cm. The axilla is sampled from medial to lateral. BLOCK SUMMARY: B1 - lateral aspect of biopsy cavity. B2 - medial aspect of the biopsy cavity. B3eB4 - tumor in upper outer quadrant B5 - tissue from lower lateral quadrant. B6 - tissue, upper inner quadrant. B7 -- tissue, lower inner quadrant. B8&B9 - nipple B10&B11 - deep margin B12 - one lymph node, serially sectioned. B13 - two lymph nodes, one inked red.. B14 - three node candidates. B15 - one lymph node B16 - highest node (near suture) INTRA OPERATIVE CONSULTATION: A. "Right breast mass (AFi)" - infiltrating ductal carcinoma present. (Dr. **REVISED DIAGNOSIS**: This report is being revised to correct the specimen "b" site from "left" to "right" breast. The remainder of the diagnosis is unchanged. A. "RIGHT BREAST MASS", (INCISIONAL BIOPSY): INFILTRATE DUCTAL CARCINOMA WITH PROMINENT CRIBRIFORM PATTERN. TUMOR SIZE; 2 CM. B. "RIGHT BREAST", (MASTECTOMY) : ult for:' I of 2
+
+--- Page 2 ---
+INFILTRATING CARCINOMA, PRESENT. HISTOLOGIC TYPE, DUCTAL WITH A PROMINENT CRIBRIFORM COMPONENT. N.S.A.B.P. HISTOLOGIC GRADE 1 OF 3. N.S.A.B.P. NUCLEAR GRADE 2 OF 3. GROSS TUMOR SIZE; 7 CM.  SEE COMMENT. INVASION TUMOR SIZE, 7 CM.  SEE COMMENT. LOCATION, UPPER OUTER QUADRANT. MULTIFOCAL TUMOR, NO. IN-SITU CARCINOMA, ABSENT. STATUS OF NON-NEOPLASTIC BREAST TISSUE; SCLEROSING ADENOSIS WITH MICROCALCIFICATIONS. LYMPHATIC/VASCULAR INVASION ABSENT. SURGICAL MARGIN STATUS, NEGATIVE. NIPPLE STATUS; PAGET'S DISEASE ABSENT. SKIN STATUS; FREE OF TUMOR. MUSCLE STATUS; NOT SAMPLED. LYMPH NODES STATUS; 9 LYMPH NODES, NO CARCINOMA IDENTIFIED (O/9). ESTROGEN/PROGESTERONE AND CELL CYCLE ANALYSIS PENDING, YES. METHODOLOGY, FRESH TISSUE. RESULTS WILL BE ISSUED IN AN ADDENDUM. cOmmENt: The tumor size in the mastectomy specimen is 7 cm in greatest dimension and the size of the tumor in the incisional biopsy is 2 cm. overall tumor size is mostly likely 9 cm in greatest dimension. The on I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es). Date ADDENDUM 1: Tissue was sent to the for assay of the estrogen and progesterone receptors. The estrogen receptor activity was judged to be positive with an estimated rmoL value of 113. The progesterone receptor activity was judged as borderline with an estimated Fmol of value of 14. Please refer to for a complete report. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es). Dat. 2 of 2
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diff --git a/output/text/17ca2a5a-71c9-4da8-af65-07fa8d3a37d5.txt b/output/text/17ca2a5a-71c9-4da8-af65-07fa8d3a37d5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d6eb927d49f14295bef25b216a1a76ef767bac8e
--- /dev/null
+++ b/output/text/17ca2a5a-71c9-4da8-af65-07fa8d3a37d5.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+ICD0-3 C'ereenonus, heysatocelllor 4 UUID:0093FD02-9219-4901-8DA2-D98AEBDCF1D5 TCGA-DD-AACC-01A-PR Redacted chslargitcsencnu csmbrick. 8/8t13 Sute: sier CRQ.D Jfs5/19/14 CLINICAL DIAGNOSIS: HCC Specimen : liver Gross Photo : 1 GROSS: 1. Specimen: Liver: 7.4 x 4.5 x 8.0 cm, 85.0 gm and 11.0 x 6.5 x 6.5 cm, 98.0 gm, unfixed Gallbladder: 12.0 cm in length, 4.5 cm in diameter, and O.2 cm in thickness, unfixed 2. Tumor location: segment 6 Tumor number: one Tumor size: 2.1 x 2.0 cm 3. Satellite nodule: no 4. Gross type HCC: vaguely nodular 5. Tumor necrosis: yes (10 %) 6. Hemorrhage/peliosis: no 7. Portal vein invasion: no 8. Bile duct invasion: no Gross photo present. Blocks RM, resection margin x 1 T1-2, tumor mass x 2 A, non-tumorous lesion x 1 GB, gallbladder x 1 MICROSCOPIC: 1. Hepatocellular carcinoma: 1-1. Differentiation The worst differentiation II The major differentiation I 1-2. Histologic type: trabecular. 1-3. Cell type: hepatic 1-4. Fatty change: yes (10 %) 2. Cholangiocarcinoma: no 3. Combined hepatocellular and cholangiocarcinoma: no 4. Fibrous capsule formation: partial capsule 5. Capsular infiltration: yes
+
+--- Page 2 ---
+6. Septum formation: no 7. Surgical resection margin invasion: no, margin of the clearence (0.1 cm) 8. Serosal invasion: no 9. Portal vein invasion: no 10. Bile duct invasion: no 11. Hepatic vein invasion: no 12. Hepatic artery invasion: no 13. Microvessel invasion: no 14. Intrahepatic metastasis: no 15. Multicentric occurrence: no Non-tumor liver pathology 1. Chronic hepatitis: 1-1. Etiology: HBV 1-2. Grade, lobular: minimal 1-3. Grade, portoperiportal: mild 1-4. Stage (fibrosis): cirrhosis 1-5. Cirrhosis: micronodular 2. Dysplastic nodule: no 3. Ductal epithelial dysplasia: no 4. Other liver diseases: no SPECIAL STAIN: Trichrome: positive (cirrhosis, stage IV). NOT reported. Gross: NOT reported. Gross: Peritoneal fluid, smear, inflammation Peritoneal fluid, smear, inflammation Liver, ectomy, hepatocellular carcinoma. T56000, P10, M81703 Gallbladder, ectomy, autolysis T57000, P10, M54001 DIAGNOSIS: Liver, segment 6, segmentectomy: Hepatocellular carcinoma, well differentiated Gallbladder, cholecystectomy:
+
+--- Page 3 ---
+Autolysis Suggestion :
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diff --git a/output/text/180899e9-3ba6-4918-ba7f-6e71cc8e3e0d.txt b/output/text/180899e9-3ba6-4918-ba7f-6e71cc8e3e0d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..17a682993f1133539210f25c5be3afa0bbb3af76
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+1cD-0-3 Carioma,l~filt^etng chucfl, nvs 8500|3 3/  page 1 / 2 lse Nbs Department of Cancer Pathology copy No. Date: Examination: Histopathological examination. Internal invoice No. Cost of diagnostic procedure 'xamination No.: Patient: xxx PESEL: XXX Age: Gender: F Material: 1. Total organ resection - left breast and axillary tissue Unit in charge: Physician in charge: Material collected on:. Material received on: Expected time of examination: up to 8 working days. Clinical diagnosis: Cancer of the left breast - outer upper quad. Examination performed on Results of immunohistochemical examination: Estrogen receptors found in over 75% of neoplastic cell nuclei. Progesterone receptors found in 10-75% of neoplastic cell nuclei. HER2 protein stained with HercepTestM by DAKO. Negative reaction in invasive cancerous cells ( Score = 1+ ) Compliance validated by:. Examination performed on: Macroscopic description: Left breast sized 19 x 18 x 5 cm removed along with axillary tissues sized 11 x 4.5 x 1.5 cm and a 19 x 10 cm skin flap. Weight 620 g. Tumour sized 2.8 x 1.5 x 2.5 cm on the border of upper quadrants, 4.5 cm from the upper boundary, 0.2 cm from the base and 1.0 cm from the skin.. Another tumour sized 0.5 x 0.7 x 0.5 cm found 1.5 cm away from the first one (margins: lower boundary - 10 cm; base -- 0.1 cm; skin - 3.5 cm). UUID:332880ED-FE4E-4EE4-9E96-0A61BFCCA27E TCGA-D8-A13D-01A-PR Redacted
+
+--- Page 2 ---
+Microscopic description:. Both tumours showing similar pattern. Carcinoma ductale invasivum bifocal - NHG2 (2 + 3 +1/7 mitoses/10 HPF, visual area diameter 0.55 mm). Foci of carcinoma ductale in situ Dcis found within the tumour (solid and cribrate type with high nuclear atypia and comedo necrosis, 5% of the tumour). Reactio lymphocytaria peritumoralis. Mamilla sine laesionibus. Glandular tissue showing mastopathia fibrosa et cystica. AXILLARY LYMPH NODES: Metastases carcinomatosae in lymphonodis No I!l/xIV. Infiltratio capsulae lymphonodis et telae perinodalis. page 2 / 2 Examination No.:. Patient: xxx  PESEL: XXX Gender: F Examination performed on Histopathological diagnosis: Carcinoma ductale invasivum bifocale mammae sinistrae. Invasive bifocal ductal carcinoma of the left breast.  Metastases carcinomatosae in lymphonodis axillae No. Ill/xiv. Cancer metastases in axillary lymph nodes No. III/xIV. (NHG2, pT2, pN1a). Compliance validated by::-
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diff --git a/output/text/18556c0d-4d42-4a6b-8ec0-7f7c7d7725ad.txt b/output/text/18556c0d-4d42-4a6b-8ec0-7f7c7d7725ad.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8582675575f19b221973fd3dbb92cbbb2661a575
--- /dev/null
+++ b/output/text/18556c0d-4d42-4a6b-8ec0-7f7c7d7725ad.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1cs-0-3 Cacinon6, mfift^stng duct, Nos 85oof3 Sire: brist Nos c50.9 4/711 OC#: : TSs #: Procurement Date:3/1/2011 Laterality:Left, upper outer quadrant Path RepOrt:BREAST TISSUE CHECKLIST Specimen type: Lumpectomy Specimen size: Not specified. Tumor site: Upper outer quadrant Tumor size: 2 x 0 x 1.8 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinoma Histologic grade: Moderately differentiated Tumor extent: Not specified. Lymph nodes: 0/10 positive for metastasis (Axillary 0/10) Extracapsular invasion of the lymph nodes: Not specified Margins: Uninvolved Nottingham Histologic Score. Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None UUID:4158FEAB-066B-4500-8FD2-3F197438DF85 TCGA-E9-A244-01A-PR Redacted
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diff --git a/output/text/1859145d-7851-455f-919d-954db1600f70.txt b/output/text/1859145d-7851-455f-919d-954db1600f70.txt
new file mode 100644
index 0000000000000000000000000000000000000000..aca7e6b92487b37f9646233257895c3e8e659dc8
--- /dev/null
+++ b/output/text/1859145d-7851-455f-919d-954db1600f70.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:D9FE314C-61F4-4E4D-BB29-48681C2A8A10 TCgA-LL-A73Z-01A-PR Redacted RUN DATE: PAGE 1 RUN TIME: RUN USER: PATIENT: ACCT #: LOC: AGE/SX: /F  ROOM: REG DR: DOB: BED: STATUS SPEC #: RECD: STATUS: COLL: TIME IN FORMALIN: hrs. COLD ISCHEMA TIME: mins. CLINICAL INFORMATION: Pre-Op Diagnosis: Remarks: Specimen(s) : A. Left breast skin biopsy B. Left breast lumpactomy - stitch marks area of interest c. Left breast frozen section ICD0-3 aenoier, cirfeltis tirs qtee+ NS 8sa3 MICROSCOPIC DIAGNOSIS SLD%urstHos "LEFT BREAST SKIN BIOPSY": c66.9 A INVASIVE CARCINOMA WITH EXTENSIVE VASCULAR LYMPHATIC INVASION pU 8/N/13 B. "LEFT BREAST LUMPECTOMY STITCH MARKS AREA OF INTEREST": INVASIVE DUCTAL CARCINOMA RECEPTORS. HER2/NEU. KI-67 ANALYSIS PENDING SEE COMMENT FOR DETAILS C. "LEFT BREAST" : INVASIVE DUCTAL CARCINOMA COMMENT(S) COLLEGE OF AMERICAN PATHOLOGISTS PROTOCOL FOR THE EXAMINATION OF SPECIMENS WITH INVASIVE CARCINOMA OF THE BREAST. BASED ON AJCC/UICC TNM. 7TH EDITION The following classification should be adjusted based on additional clinical information. PROCEDURE : Excision without wire-guided localization. skin biopsy. left breast biopsy LYMPH NODE SAMPLING: No lymph nodes identified SPECIMEN LATERALITY: Left HISTOLOGIC TYPE OF INVASIVE CARCINOMA: Invasive ductal carcinoma TUMOR SIZE: 2.0 cm HISTOLOGIC GRADE: Grade 3 Tubular Differentiation Score: 3. Nuclear Pleomorphism Score: 3. Mitotic Rate Score: 2 TUMOR FOCALITY: Single focus of invasive carcinoma. DUCTAL CARCINOMA IN SITU: Present high grade, not extensive. ** CONTINUED ON NEXT PAGE **
+
+--- Page 2 ---
+RUN DATE: PAGE 2 RUN TIME: RUN USER: PATIENT: (Continued) SPEC #:' COmment(S) (Continued) MACROSCOPIC/MICROSCOPIC EXTENT OF TUMOR:S Skin: Invasive carcinoma directly invades into dermis without ulceration MARGINS: Margins involved by invasive carcinoma. Margins uninvolved by ductal carcinoma in situ. No lymph nodes identified LYMPH NODES: LYMPH-VASCULAR INVASION: Present DERMAL-LYMPHATIC INVASION: Present PATHOLOGIC STAGING: Primary Tumor: pTlc Lymph Nodes: pNX Distant Metastasis: Not applicable ANCILLARY STUDIES: Receptors. Her2/Neu. Ki-67 analysis pending Fibrocystic changes. ADDITIONAL PATHOLOGIC FINDINGS: GROSS DESCRIPTION:S In formalin labeled with the patient's name and "left breast skin biopsy" is a 3 x 0.8. A x 1.5 cm wedge biopsy of brown skin and underlying fatty tissue. The specimen is bisected lengthwise and totally submitted in blocks Al and A2.. B.  Received fresh labeled with the patient's name and "left breast lumpectomy. stitch marks area of interest" is a 7 gram aggregate of fibroadipose tissue. The specimen measures 6 x 5 x 2 cm. There is one portion which is sutured. and this portion measures 4 x 2 x 1.5 cm. On cross section. this portion shows an admixture of adipose tissue and. streaky gray-white tissue possibly representing tumor.. A section of this portion is submitted in blocks B1-B3.  Additional sections of the other fragments of tissue are. submitted in blocks B4-B6. C.  Received fresh for frozen section labeled with the patient's name and "left breast" are several fragments of firm. fatty tissue which measure together 2.5 x 2 x 1 cm. A representative portion of the firmer area is submitted in block C1 for frozen section. A cytologic scrape prep is prepared for Diff-Quik stain. The complimentary tissue submitted for frozen section is provided to the Tissue Bank coordinator.  The remainder of the soft tissue is submitted in block c2 for permanent section.. MICROSCOPIC DESCRIPTION: E-cadherin stains on specimens B and c demonstrate that they are positive.. Control block stained appropriately. INTRAOPERATIVE CONSULTATION: C . FROZEN SECTION DIAGNOSIS. LEFT BREAST BIOPSY: MALIGNANT CONSISTENT WITH INVASIVE CARCINOMA. POSSIBLE PLEOMORPHIC LOBULAR CARCINOMA TISSUE PROVIDED TO TISSUE BANK COORDINATOR RESULTS PHONED TO * CONTINUED ON NEXT PAGE **
+
+--- Page 3 ---
+RUN DATE PAGE 3 RUN TIME RUN USER SPEC #: PATIENT: (Continued) PHOTO IOCUMENTATION Image . Signed (signature on file)... ** END OF REPORT ** w 8ND
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diff --git a/output/text/1861cde9-0cab-4501-b40a-e65db6f1dbaa.txt b/output/text/1861cde9-0cab-4501-b40a-e65db6f1dbaa.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fc75bd21d2ac4c86eb781b99b061ec850e1b79c7
--- /dev/null
+++ b/output/text/1861cde9-0cab-4501-b40a-e65db6f1dbaa.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+ics-0 - 3 Page l of juuamns CU eutinms,iNv5 UUID:F98AC018-6C95-44F5-BEF4-4A5C422970C4 CGA-DS-A0VN-01A-PR Redacted 8070|3 Si+: cevix,NDs 13/7f10 c53.9 Ordering MD: Copies to: DIAGNOSIS: 9. UTERUS, HYSTERECTOMY: -Cervical invasive squamous cell carcinoma, moderately differentiated, keratinizing; see Comment -Size: 8.0 cm -Depth of invasion: 1.3 cm. -0.1 cm from closest deep cervical margin. -1.0 cm from closest vaginal cuff resection margin -Extends to lower uterine segment/isthmus -No tumor identified in 8 small parametrial lymph nodes -Lympho-vascular invasion is not identified. -Leiomyoma -Adenomyosis and adenomyoma -Benign secretory endometrium 1. RIGHT ADNEXA, SALPINGO-OOPHORECTOMY: -Ovary with hemorrhagic corpus luteum cyst and cystic follicles -Fallopian tube with cystic walthard rests -No malignancy is identified 2. LEFT ADNEXA, SALPINGO-OOPHORECTOMY: -Ovary with cystic follicles and focal organizing hemorrhage -Fallopian tube with cystic walthard rest -No malignancy is identified 3. LEFT PELVIC LYMPH NODE, BIOPSY: -Three lymph nodes negative for malignancy. 4. LEFT OBTURATOR, BIOPSY:S -Three lymph nodes negative for malignancy 5. RIGHT PELVIC LYMPH NODES, BIOPSY: -One lymph node negative for malignancy 6. OBTURATOR, BIOPSY: -One lymph node negative for malignancy (continued on next page) Department of Pathology & Laboratory Medicine. raye: 7. RIGHT PARAMETRIUM, BIOPSY: -Three small lymph nodes negative for malignancy. 8. FROZEN SECTION OBTURATOR, BIOPSY: -Two lymph nodes negative for malignancy 10. PERIAORTIC LYMPH NODE, BIOPSY: -Four lymph nodes negative for malignancy 11. RIGHT COMMON ILIAC, BIOPSY: -Two lymph nodes negative for malignancy https:/
+
+--- Page 2 ---
+Page 2 of 12. LEFT COMMON ILIAC, BIOPSY: -Adipose tissue negative for malignancy Comment:  The tumor abuts the ectocervical-vaginal junction. Cervical intraepithelial neoplasia is not identified; however,. essentially the entire cervix has been replaced by squamous cell carcinoma. HISTORY:  Cervical carcinoma MICROSCOPIC: See Diagnosis. GROSS : 1: RIGHT ADNEXA Labeled "right adnexa" and received in formalin is an ovary with attached fallopian tube. The specimen weighs 13 grams. The ovary measures 3.7 x 2.2 x 1.5 cm and has firm yellow focally hemorrhagic mildly lobulated surface. Sectioning of the ovary reveals a corpus luteum measuring up to 2.2 cm in greatest dimension and also one smooth wall cyst filled with clear fluid and with a wall thickness up to 0.1 cm. The fallopian tube has fimbria at one end and is 3.7 cm long and has an average diameter of 0.7 cm. Attached to the fallopian tubes there are three thin wall translucent fluid filled cysts measuring from 0.1 to 0.2 cm in diameter. Sectioning of the tube reveal a patent lumen measuring up to o.1 cm in diameter. Representative sections submitted. A. Right ovary - 1 B. Right fallopian tube and mesosalpinx - 4 2 : LEFT ADNEXA Labeled "left adnexa" and received in formalin is an ovary with attached fallopian tube. measures 3.0 x 1.7 x 1.2 cm, has pink-yellow lobulated smooth surface. Section reveals approximately eight cystic spaces ranging in size from 0.3 to 0.8 cm: The walls are smooth and have maximum thickness of 0.1 cm. The attached fallopian tube measures 4.0 cm in length and has a fimbriated end. The tube measures 0.5 cm in average diameter with tan-pink serosa.  Section of the fallopian tube shows a lumen measuring up to o.1 cm in diameter. Representative sections. C. Left ovary - 1 D. Left fallopian tube and mesosalpinx - 3 (continued on next page) artment of pathology & Laboratory Medicine Page: 3 LEFT PELVIC LYMPH NODE 3 Labeled "left pelvic lymph node" and received in formalin is an aggregate of soft yellow lobulated fat measuring 5.5 x 5.0 x 1.5 cm. Section of the fat reveals three soft tan unremarkable lymph nodes ranging in size from 0.8 to 1.4 cm.  Lymph nodes are entirely submitted. E. Two lymph nodes bisected - 4 F. One lymph node bisected - 2 4 : LEFT OBTURATOR Labeled "left obturator" and received in formalin is an aggregate of soft yellow lobulated fatty tissue measuring 5.0 x 5.0 x 0.8 cm. Section reveals three tan-pink soft unremarkable lymph nodes measuring from 1.0 cm to 2.7 cm. Lymph nodes are entirely submitted. G. One lymph node bisected - 2 H,I. Lymph node bisected - 1 each J. One lymph node bisected - 2 5 :  RIGHT PELVIC LYMPH NODES Labeled "right pelvic lymph nodes" and received in formalin is an aggregate of soft yellow lobulated adipose tissue measuring 6.0 x 5.0 x 1.5 cm.  Section reveals one soft tan-pink grossly unremarkable. https:/.
+
+--- Page 3 ---
+Page 3 of lymph node measuring up to 2.0 cm in greatest dimension. Lymph node entirely submitted. K. One lymph node bisected - 2 6 : OBTURATOR Labeled "obturator" and received in formalin is an aggregate of soft yellow lobulated fatty tissue measuring 4.0 x 3.5 x 0.8 cm. Sectioning reveals one soft tan-pink grossly unremarkable lymph node measuring 1.5 cm in greatest dimension. Lymph node entirely submitted. L. One lymph node bisected - 2 7 : RIGHT PARAMETRIUM Labeled "right parametrium" and received in formalin is an irregular portion of tan-yellow focally hemorrhagic membranous adipose tissue measuring 2.5 x 2.0 x 0.3 cm.  Entirely submitted. M. 1 8: FROZEN SECTION OBTURATOR Labeled "frozen section obturator", received fresh in the Operating Room for frozen section diagnosis and subsequently fixed in formalin are two lymph nodes measuring 3.5 x 1.5 x 0.8 cm and 4.5 x 1.8 x 1.5 cm. Two cuts of the larger lymph node was utilized for frozen section. The rest of the lymph node tissue entirely submitted.. N. Frozen section remnant - 2 O-Q. Large lymph node - multiple R,S. Smaller lymph node - 4 each UTERUS Labeled "uterus" and received in formalin is a 260 gram hysterectomy specimen. The uterus is symmetric and measures 10.5 cm from fundus to ectocervix, 8.0 cm cornu to cornu and 6.5 cm anterior to 8.5 cm. The cervix is largely replaced by a firm tan-red, ulcerated, fungating mass. The barrel shaped mass measures 8.0 x 5.0 x 3.0 cm. The mass is 0.1 cm, 0.6 cm, 0.4cm, and 0.6 cm from the (continued on next page) lepartment of Pathology & Laboratory Medicine Page: deep cervical margins ot the posterior, anterior, left, and right respectively (deep margin being the external surface of the cervix). A vaginal cuff surrounds the mass and measures .0 cm wide posteriorly to 4.0 cm wide anteriorly.  The tumor is therefore 1 cm from the closest vaginal resection margin.  The mass involves the whole endocervical canal and extends into the lower uterine. segment/isthmus. The bulk of the uterine corpus is grossly uninvolved.  The endometrial cavity measures 4.0 cm long and 3.7 cm wide, and is covered by tan soft, smooth endometrium that measures up to 0.5 cm in thickness. Section of the uterine corpus reveal mildly trabecular myometrium and two intramural and one subserosal, well circumscribed firm tan-white whorled masses without grossly evident hemorrhages or areas of necrosis. inked blue. Representative section submitted. T. Mass and posterior resection margin - 1 U. Left resection margin - 1 V. Posterior right vaginal resection margin - 2 W. Posterior left vaginal resection margin - 2 X.  Anterior right vaginal resection margin - 2 Y. Anterior left vaginal resection margin  Mass and anterior resection margin - 1 Z. AA. Myometrial tissue - BB. Anterior uterine corpus - 1 cc. Posterior uterine corpus - 2 Anterior lower uterine segment - 1 HH. Posterior lower uterine segment - 1 II. Mass and ectovervix-vaginal cuff junction- 1 https:/i.
+
+--- Page 4 ---
+Page 4 of 10: PERIAORTIC LYMPH NODE Labeled "periaortic lymph node" and received in formalin is an aggregate of soft yellow lobulated focal hemorrhagic adipose tissue measuring 2.2 x 2.0 x 0.5 cm. Sectioning reveals four soft tan-pink grossly unremarkable lymph nodes ranging in size from 0.6 to 1.4 cm. Lymph nodes entirely submitted.. DD. Four lymph nodes, two bisected - 6 11: RIGHT COMMON ILIAC Labeled "right common iliac" and received in formalin are two soft. tan-pink grossly unremarkable lymph nodes measuring 1.0 and 1.7 cm in greatest dimension. Entirely submitted.. EE. Two lymph nodes bisected - 4 12. LEFT COMMON ILIAC Labeled *left common iliac" and received in formalin is an irregular portion of soft yellow lobulated fatty tissue measuring 1.5 x 0.6 x 0.2 cm. No lymph nodes identified. Entirely submitted. FF. 1 Gross dictated by OPERATIVE CONSULT (FROZEN) : (continued on next page) nenartment of Pathology & Laboratory Medicine Page: 5 FS #8: OBTURATOR LYMPH NODES: Sampled representative sections (of the largest node): Reactive lvmoh node with no evidence of tumor M.D.) Note: A 2.5 x 1.5 x 0.6 cm portion of tumor is harvested for Dr. Special studies: Frozen Section. See Also:  None DATE : Pathologist I, M.D., the pathologist of record, have personally examined the specimen, interpreted the results, reviewed the report and signed it electronically. Date Finalled:: https://
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diff --git a/output/text/188b3e18-7fab-4bf5-a0a5-291c2cf47816.txt b/output/text/188b3e18-7fab-4bf5-a0a5-291c2cf47816.txt
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index 0000000000000000000000000000000000000000..408466f5390bc066b1bd555ddff21362b0bf22ca
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+--- Page 1 ---
+Clinical Diagnosis & History: y/o female with biopsy proven left ILc at mastectomy and SLN/possible ALND.  Scheduled for left total Specimens Submitted: 1: sP: Sentinel node #1, level 1, left axilla (fs) 2 : SP:  Sentinel node #2, level 2, left axilla (fs) SP Sentinel node #3. level 2. left axilla (fs) 4: SP: 5: SP: Left breast (sr) 6 : Sp:  Non-sentinel node level 1, left axilla 7: Sp: Left axillary contents level 1 8: SP: Left axillary contents level 2 ana tag UUID:E39B6625-6674-4665-9BEE-D4DFD9366A02 TCGA-AO-A033-01A-PR Redacted DIAGNOSIS: 1) LYMPH NODE, SENTINEL #1 LEVEL I LEFT AXILLA; BIOPSY: METASTATIC MAMMARY CARCINOMA INVOLVING ONE OF ONE LYMPH NODE (1/1).) - NO EXTRANODAL TUMOR EXTENSION IS PRESENT. 2) LYMPH NODE, SENTINEL #2 LEVEL II LEFT AXILLA; BIOPSY:S -ONE BENIGN LYMPH NODE (0/1). 3) LYMPH NODE, SENTINEL #3 LEVEL II LEFT AXILLA; BIOPSY: - ONE BENIGN LYMPH NODE (O/1). 4) LYMPH NODE. SENTINEL #4 LEVEL I LEFT AXILLA; BIOPSY: -ONE BENIGN LYMPH NODE O/1). 5) BREAST, LEFT; MASTECTOMY: - INVASIVE LOBULAR CARCINOMA, CLASSICAL TYPE, DIFFUSELY INVOLVING THE SUBMITTED TISSUE SECTIONS.  THE LARGEST DIMENSION OF THE INVASIVE CARCINOMAS CANNOT BE ACCURATRLY DETERMINED BECAUSE OF ITS DIFFUSE NATURE, BUT BASED ON GROSS EXAMINATION IT IS ESTIMATED THAT THE INVASIVE CARCINOMA SPANS AN AREA OF ABOUT 4.5 CM. - THE BASE OF THE NIPPLE IS ALSO INVOLVED BY INVASIVE LOBULAR CARCINOMA.  LOBULAR CARCINOMA IN SITU (LCIS). - MICROCALCIPICATIONS ARE PRESENT IN BENIGN (ENTRAPPED) BREAST PARENCHYMA.  LYMPHOVASCULAR INVASION IS PRESENT. - NO INVOLVEMENT OF THE SURGICAL MARGINS BY CARCINOMA IS IDENTIFIED.S ** Continued on next page **? 1cs-0-3 Circinorns, mfittnstry 1o bulan, iigs 8520j3 Sih: brust, nos c5o.9 b. 10/34Ju se is (circle
+
+--- Page 2 ---
+ SKIN WITH SCAR. Page 2 of 6 - THE REMAINING NON-NEOPLASTIC BREAST TISSUE SHOWS BIOPSY SITE CHANGES AND FOCAL DUCTAL HYPERPLASIA WITH FOCAL ATYPIA. - ONE AXILLARY LYMPH NODE IS POSITIVE FOR METASTATIC MAMMARY CARCINOMA (1/1). - NO EXTRANODAL TUMOR EXTENSION IS PRESENT. - RESULTS OF IMMUNOHISTOCHEMICAL STAINS ARE AS FOLLOWS: ER  95% NUCLEAR STAINING WITH STRONG INTENSITY PR: 70% NUCLEAR STAINING WITH MODERATE TO STRONG INTENSITY HER-2/NEU (HERCEPTEST) : NEGATIVE (STAINING INTENSITY OF 0) 6) LYMPH NODE, NON-SENTINEL LEVEL I LEFT AXILLA; BIOPSY:S - ONE BENIGN LYMPH NODE (O/1). 7) LYMPH NODES, LEFT AXILLARY CONTENTS LEVEL I; DISSECTION: TWENTY-TWO BENIGN LYMPH NODES (0/22). 8) LYMPH NODES, LEFT AXILLARY CONTENTS LEVEL II; DISSECTION: SIXTEEN BENIGN LYMPH NODES (0/16) . I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL). AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT.S Special Studies:s Result Special stain. Comment RECUT ER-C PR-C HER2-C NEG CONT IMM RECUT NEG-HER2 RECUT Gross Description: 1) The specimen is received fresh and is labeled "Sentinel node #1 level. I' axilla" and consists of one lymph node measuring 1.5 x 0.8 x 0.4 cm. Bisected and entirely submitted for frozen section. Summary of sections: FSC - frozen section control 2) The specimen is received fresh, labeled "Sentinel node #2 level 2 left axilla" and consists of one lymph node measuring 0.8 x 0.5 x 0.3 cm. ** Continued on next page **
+
+--- Page 3 ---
+Entirely submitted for frozen section. Page 3of6 Summary of sections: Fsc - frozen section control M.D. The specimen is receivad fresh, labeled nSentinel node #3 level 2 left axilla" and consists of one lymph node measuring 1.0 x 0.5 x 0.3 cm. Entirely submitted for frozen section. Summary of sections: FSC - frozen section control ,M.D. 4) The specimen is received fresh and is labeled "Sentinel node #4 level 1 left axilia" and consists of a lymph node measuring 1.5 x 0.5 x 0.4 cm. Entirely submitted for frozen section. Summary of sections: FSc - frozen section control M.d. 5) The specimen is received fresh labeled, "Left breast, stitch marked axillary taii" and consists of a breast with attached axillary tail. The breast measures 35.5 x 24.0 x 3.8 cm with overlying skin ellipse measuring 13.5 x 7.5 cm.  Situated centrally on the skin surface is an unremarkable nipple measuring 1.2 x 1.2 x 0.8 cm and areola measuring 3.9 x 3.9 cm. skin shows a  linear scar measuring 8.0 cm, situated vertically near the The nipple. A suture demarcates the axillary tail which measures 4.5 x 3.5 x 3.5 cm Sectioning the breast reveals a biopsy cavity, measuring 4.2 x 3.5 x 4.0 cm with a fibrotic area superior to the cavity. mass is present, measuring 4.5 x 4.5 x 2.7 cm, located lateral to the nipple One  ill-defined tan in uoQ and 3.5 cm from the deep surgical margin. tissue shows unremarkable intermingling of fatty and fibrotic areas.  The remaining breast axillary tissue is dissected to reveal one lymph node, measuring 1.1 x 0.5 x The 0.5 cm. Representative sections are submitted. submitted to A portion of tumor is Sunmary of sections: N - nipple NB - nipple base S - skin scar - deep margin T tumor UIQ upper inner quadrant LIQ lower inner  quadrant UOQ upper outer  quadrant LOQ lower : outer  quadrant LNS lymph  node ** Continued on next page *
+
+--- Page 4 ---
+M.D. 6) The specimen is received in formalin is labeled "Non-sentinel node. lavel 1 left axilla" and consists of a tan soft lymph node measuring 1.0 x 1.0 x 0.7 cm. Entirely submitted. Summary of sections: LN - lymph node (bisacted) M.D. 7) The specimen is received in formalin and is labeled "Left axillary. contents level 1* and consists of multiple lymph nodes and fat measuring 8.0 x 7.0 x 1.1 cm in aggregate. The lymph nodes measure from 0.2 cm to 3.0 cm in greatest dimension. The lymph nodes are entirely submitted.. Summary of sections: BLN1 -' bisected lymph node BLN2 - bisected lymph node LN - lymph nodes M.D. 8)  The specimen is received in formalin labeled rLeft axillary contents level 2 and tag" and consists of mltiple lymph nodes and attached fat measuring 5.0 x 4.0 x 0.6 cm. The lymph nodes measure from 0.3 cm to 0.5 cm. in greatest dimension. The lymph nodes are entirely submitted.. Summmary of sections: LN - lymph nodes Summary of Sections: Part 1:  SP: Sentinel node #1, level 1, left axilla (fs) Block Sect. site PCs 1 fsc 1 Part 2: SP: Sentinel noda #2, level 2, left axilla (fs) Block Sect. Site PCs 1 fsc 1 Part 3: SP: Sentinel node #3, level 2. left axilla (fs) Block Sect. Site 1 PCs fsc 1 Part 4:  Sp: Sentinel node #4, level 1. left axilla (fs) ** Continued on next page **
+
+--- Page 5 ---
+lock Sect. .Site PCs fsc Part 5: SP: Left breast Block Sect. Site PCs dm 1iq 2 Ins 1 1oq 2 1 n 1 nb 1 sk 5 5 2 uiq N 2 2 uoq Part 6: SP: Non-sentinel node level 1, left axilla. Block Sect. site pCs 1 1n 1 Part 7: SP: Left axillary contents level 1. Block Sect. Site PCs 22 bln1 bln2 2 In 2 6 6 Part 8:  SP: Left axillary contents level 2 and tag. Block Sect. Site PCa 3 1n Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS METASTATIC CARCINOMA. PERMANENT DIAGNOSIS:  SAME FROZEN SECTION DIAGNOSIS 2 NO CARCINOMA IDENTIFIED. PERMANENT DIAGNOSIS: SAME 3) FROZEN SECTION DIAGNOSIS NO CARCINOMA IDENTIFIED. PERMANENT DIAGNOSIS: SAME 4) FROZEN SECTION DIAGNOSIS NO CARCINOMA IDENTIFIED PERMANENT DIAGNOSIS: SAME Continued on next page.
+
+--- Page 6 ---
+End of Report
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index 0000000000000000000000000000000000000000..ed2fac95dda1968f62fef492b7f5e6ea4d557ee5
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+--- Page 1 ---
+Clinical Diagnosis & History y/o male with left renal mass with lymphadenopathy. R/o renal cell cancer. Specimens Submitted: 1:SP:Left kidney and portion of left adrenal, total nephrectomy 2SPLymph nodesPara-aorticexcision 3:SPLymph nodesPre-aorticexcisions 4:SP:Lymph nodesInteraortocaval, excision 5:SP:Lymph nodes, Suprahilar and portion of left adrenal, excision 6:SPLiverleft lobebiopsy DIAGNOSIS: SP:Left kidney and portion of left adrenal, total nephrectomy Tumor Type: Renal cell carcinoma-Chromophobe type Tumor Size: Greatest diameter is 13.0 cm. Local Invasion (for renal cortical types): Extends through renal capsule but confined within Gerota's fascia Involves renal hilar fat Renal Vein Invasion: Identified Surgical Margins: Free of tumor Non-Neoplastic Kidney: Unremarkable Adrenal Gland: Notinvolved Lymph Nodes: Not identified Staging for renal cell carcinoma/oncocytoma: pT3b Tumor grossly extends into the renal vein(s) or vena cava below the diaphragm Page1of4
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT 2. SP:Lymph nodes,Para-aortic,excision: Lymph Nodes: Not involved Number of nodes examined:15 3.SP:Lymph nodes,Pre-aortic,excisions Lymph Nodes: Not involved Number of nodes examined:12 SP:Lymph nodes,Interaortocaval, excision Lymph Nodes: Not involved Number of nodes examined:2 5.SP:Lymph nodes,Suprahilar and portion of left adrenal,excision Lymph Nodes Number of nodes examined:4 Number of metastatic nodes:1 The largest metastatic node is 1.3cm Perinodal (extracapsular) extension not identified Unremarkable adrenal gland 6.Liver,left lobebiopsy -Metastatic renal cell carcinoma,chromophobe type, involvingliver parenchyma IATTEST THAT THE ABOVE DIAGNOSIS IS BASEDUPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHERMATERIAL),AND THAT IHAVE REVIEWED AND APPROVED THIS REPORT. Special Studies: Result Special Stain Comment MIB-1Ki-67 IMM RECUT NEG CONT RECUT RECUT RECUT RECUT RECUT RECUT RECUT RECUT RECUT RECUT Gross Description: 1) The specimen is received fresh labeled "left kidney and portion of left adrenal" and consists of a kidney with attached ureter, renal vessels and perinephric fat weighing 1258 g in total.The kidney measures 13x12x10 cm.The attached ureter measures Page2 of4
+
+--- Page 3 ---
+SURGICAL PATHOLOGYREPORT 1.0 cm in length and0.5 cm in diameter. The attached renal vein measures 1.0 cm in length and 1.0 cm in diameter.The renal vessels and ureter margins are grossly unremarkable.An adrenal gland is identified,measuring 4.Ox1.Ox1.0 cm.The kidney is inked black and bivalved to reveal a large necrotic mass, completely replacing the entire kidney with rim normal renal parenchyma in the hilar area and measuring 13x12x10cm.Tumor thrombus is identified in the renal vein,but the margin is free of tumor.The renal cortex measures 0.5 cm in thickness and the calyces appear involved by the tumor.The specimen is photographed. Representative sections are submitted for and for permanent sections. Summary of sections: UVM--ureteral and vessel margins Ttumor TH-tumor in the hilar area TK--tumor with adjacent kidney Thr-tumor thrombus K--representative sections kidney AD-adrenal gland HF-hilar fat 2).The specimen is received in formalin, labeled Para-aortic nodes" and consists of multiple pink tan firm lymph nodes ranging from 0.6 to 3 cm in greatest dimension.All identified lymph nodes are submitted. Summary of sections LN--lymph nodes BLN--bisected lymph nodes 3).The specimen is received in formalin, labeled Pre-aortic nodes" and consists of multiple pink tan firm lymph nodes ranging from 0.6 to2.6 cm in greatest dimension.All identified lymph nodes are submitted. Summary of sections: LN--lymph nodes BLN--bisected lymph nodes 4).The specimen is received in formalin,labeled "Interaortocaval lymph node" and consists of two pink tan firm lymph nodes measuring from 0.8 and 2.5 cm in greatest dimension.All identified lymph nodes are submitted. Summary of sections: LN--lymph nodes BLN--bisected lymph node 5).The specimen is received in formalin,labeled "Suprahilar nodes and portion of left adrenal" and consists of a piece of brown tan fibrous adipose tissue measuring 6 x2.7 x 1.3 cm.Multiple pink tan firm lymph nodes are isolated ranging from 1 to 1.6 cm in greatest dimension. All identified lymph nodes are submitted.A golden yellow portion of adrenal gland is identified measuring 3.5 x 2.2 x 1cm.Serial sections of the gland reveal a homogeneous golden yellow parenchyma and is entirely submitted. Summary of sections: LN--lymph nodes BLN--bisected lymph nodes U- sections from adrenal gland 6). The specimen is received in formalin, labeled Biopsy left lobe of liver' and consists of a portion of brown-tan firm liver tissue measuring 1.4 x 0.6 x 0.3 cm.The surgical margin is inked in black and the specimen is bisected and entirely submitted. Summary of sections: U-undesignated Summary of Sections: Page3of4
+
+--- Page 4 ---
+SURGICAL PATHOLOGY REPORT Part 1: SP:Left kidney and portion of left adrenal, total nephrectomy Block Sect.Site PCs 1 ad 1 2 hf 2 1 k 1 t 7 2 th 2 1 thr 1 1 tk 1 1 uvm 1 Part 2:SP:Lymph nodes,Para-aorticexcision: Block Sect.Site PCs 4 BLN 6 3 LN 6 Part 3:SP:Lymph nodes,Pre-aortic,excisions Block Sect.Site PCS 4 BLN 6 3 LN 4 Part 4:SP:Lymph nodes,Interaortocaval, excision Block Sect.Site PCs 2 BLN 2 1 LN 1 Part 5: SP:Lymph nodes,Suprahilar and portion of left adrenal, excision Block Sect.Site PCs 2 BLN 4 1 LN 2 4 U 4 Part 6:SP:Liverleft lobe,biopsy Block Sect.Site PCs U 2 7 Page4 of4 END OFREPORT
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+--- Page 1 ---
+*** Diagnosis / Diagnoses: *** 1.: Partial colectomy specimen with portions of the terminal ileum and an ulcerated colon carcinoma conforming to the histological type of a moderately differentiated colorectal carcinoma, located 50 cm aborally from Bauhin's valve and circularly occupying the colon wall over a length of 5.5 cm. Invasive spread of tumor within all layers of the intestinal wall and extending into the level of the mesocolic fatty tissue. Colon otherwise with three tubulovillous colonic mucosal adenomas, two of which exhibit mild epithelial dysplasia (synonym: low-grade intra-epithelial neoplasia), one with severe epithelial dysplasia (synonym: high-grade intra-epithelial neoplasia). In the cecum and O.6 cm aboral to Bauhin's valve, a fresh, ulcerous mucosal defect - status following prior endoscopic removal of adenomas and with no further portions of the adenomas that were removed.. Oral and aboral resection margins and large omentum tumor-free. 54 mesocolic and mesenteric lymph nodes tumor-free with uncharacteristic reactive changes. Tumor stage thus: pT3 pN0 (0/54), L0, V0; G2. + pT? in cecum 2.: Gall bladder with moderate, barely florid, chronic cholecystitis, probably with cholecystolithiasis.
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diff --git a/output/text/18e0c492-c6b0-4361-a634-919e5f9fb9a5.txt b/output/text/18e0c492-c6b0-4361-a634-919e5f9fb9a5.txt
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index 0000000000000000000000000000000000000000..c72c63b1f42ccf67ed7d9f2265f1e869f6ffc449
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+
+--- Page 1 ---
+1CD-0-3 Cavcinoma, infiltnst`vg ductal, nos b5oo/3 C50.5 Pisth Sit: brast, LOQ. 1/35/ S;h: brst,Nos c5o.9 CQcF Diagnosis 1. and 2. Poorly differentiated invasive ductayright breast carcinoma measuring up to 4.4 cm with a minimum dorsal margin of 2.9 cm in the ablated breast tissue. Circumscribed ductal carcinoma in situ (high-grade DCIS with comedo necrosis) in the tumor center, about 0.2 cm in diameter. Lipomatous atrophy of the remaining breast tissue. Regular nipple. Regular skin. Sixteen right axillary lymph nodes free of metastases (0/16). Tumor classification: M-8500/3, G 3, pT2, pN0 (0/16), pMX, stage II A. UUID:AF12859A-D67A-488D-8BC2-ED28698F2ACA Redacted TCGA-A8-A09I-01A-PR
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diff --git a/output/text/19031e74-1099-49e1-9a71-e27efd973092.txt b/output/text/19031e74-1099-49e1-9a71-e27efd973092.txt
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index 0000000000000000000000000000000000000000..790022ca884974c09202c7f9bbd925fe4b5746ac
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+PREVIOUS DIAGNOSIS INQUIRY UUID:095AE671-9808-4895-B6FD-EDA3F7F9E69D TCGA-OR-A5JT-01A-PR Redacted PAGE#: SEX:F PAT TYPE: ADM DATE: OPER DATE: PROCEDURE: SPHS Operative Procedure/Tissue Submitted: Open adrenalectomy-left. PROCEDURE: SPGD 1. "Lett adrenal mass and spleen." Received in formalin in a large container is a 480 gm adrenal mass (11.5 x 10.0 x 8.5 cm) with attached capsular adipose tissue and spleen (160 gm; 11.8 x 7.5 x 2.0 cm). The mass is opened to reveal a tan-yellow, partially necrotic tumor (necrosis) predominantly in the inferior portion with a thickened capsule superiorly and numerous nodules that appear to traverse the capsule into adjacent fat. Inking as follows: superior blue, inferior green, posterior black, anterior yellow, medial red and lateral orange. Eight possible lymph nodes are identified (the largest 1.3 cm) in the periadrenal fat. The splenic vein is opened and appears to be free of tumor. Secticning of the mass reveals encroachment of the tumor onto periadrenal adipose at multiple margins.. 1A-H. Representative sections through capsule.. 11. Largest lymph node trisected. 1J. Seven possible lymph nodes.. 1K-Q. Representative sections through capsule. 1R. Representative section through spleen at hilun. 2. "Retroperitoneal lymph node dissection." Received in formalin in a small tall container are three fragments of fibroadipose tissue (in aggregate 4.2 x 2.5 x 2.0 cm). Eleven possible lymph nodes identified (0.5 to 1.8 cm). 2A. Seven possible lymph nodes. 28. Largest possible lymph node bisected.. 2c. Next largest lymph node bisected.. 2D. Ore possible lymph node bisected.. 2E. Ore possible lymph node bisected.. Fat retained. 3. "Diaphragm." Received in formalin in a small tall container are two, tan-gray, soft tissue fragments. Submitted whole in 1 cassette. 3A. IC D-6-3 PROCEDURE: SPMI Ca rcinoina,adreual eortica! 8370|3 Site:  Adrerod Glaud,cortex ADRENOCORTICAL CARCINOMA V4 C 74.O Jumor Size: 11.5 x 10.0 x 8.5 cm J Tumor Weight: 480 grams
+
+--- Page 2 ---
+PREVIOUS DIAGNOSIS INQUIRY REPORT DATE: PAGE #: SEX: | F BIRTHDATE: OPER DATE: Capsular Invasion: No Vascular Invasion: No. Surgical Margins: Free. Necrosis: Extensive Mitotic Rate: 5 mitoses per 50 high power field Grade: Low grade Lymph nodes status: 0/17 lymph nodes Extra-adrenal extension: Negative Stage: 12 NO PROCEDURE: SPDX 1. Left adrenal gland and spleen, resection: Low grade adrenocortical carcinoma (11.5 cm, 480 gm) with extensive necrosis. No capsular or vascular invasion. Surgical margins free. Nine lymph nodes, negative for carcinoma (0/9). Incidental adrenocortical adenoma. Histologically unremarkable spleen. 2. Soft tissue of retroperitoneum, lymph node dissection: Eight lymph nodes, negative for carcinoma (0/8). Histologically unremarkable ganglia. 3. Diaphragm, resection: Histologically unremarkable fibromuscular tissue. Negative for carcinoma.. e signing staff pathologist, have personally examined and'interpreted the stides from this case. 1322\12 HIPAA Discrepa
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diff --git a/output/text/19061370-7c3d-447f-b285-e1cb3e8a2562.txt b/output/text/19061370-7c3d-447f-b285-e1cb3e8a2562.txt
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+UUID:F694CBD6-880D-40C7-AB17-D0AD0287F06B Redacted Not for Permanent Storage in Medical Records / Not Valid for Signing Requested by: Patient MRN Date of Service. Performing Facility Ordering Provider Result Provider Report Name :Surgical Report carcnoma, infilnating 1obular, Nos|8520/ 3 Sit: brenst, nos C50.9 SEE REPORT ADDENDUM INFORMATION PROCEDURE DATE ADDENDUM REPORT #1: COMMENT: -- Immunoevaluation using Assisted Quantitative Image Analysis has been completed and is summarized under line 10 of the diagnosis below. T: -ADDENDUM REPORT #1; DIAGNOSIS:  A, B/BPC & C. RIGHT; BREAST, MASTECTOMY WITH SENTINEL LYMPH NODE BIOPSY ANI FOLLOW UP AXILLARY DISSECTION: 1 - 9. SEE ORIGINAL DIAGNOSIS 10. ANCILLARY STUDIES: SEE BELOW ASSAY RESULTS Test. Staining Intensity % Positive Avg Prognostic Significance ER N/A 66% Favorable. N/A PR 7% Favorable  Her2/neu 0.4. N/A Normal Limit K1-67 N/A 11% Borderline REFERENCE RANGES Test Favorable Borderline Unfavorable ER >5% <5% PR >5% <5%  Her2/neu <2.0 >2.0 Ki-67 <10% >10% - <20% >20% A-MAL IGNANT MD T: (Electronic Signature) SURGICAL PATHOLOGY REPORT PROCEDURE DATE: - SPECIMEN DESCRIPTION: A. RIGHT BREAST 8. RIGHT AXILLARY SENTINEL LYMPH NODE, BPCE C.  RIGHT AXILLARY NODE -= PRE-OPERATIVE DIAGNOSIS: Right breast carcinoma. - POST-OPERATIVE DIAGNOSIS: Same, pending pathology consultation. = CLINICAL INFORMATION:
+
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+Not for Permanent Storage in Medical Records / Not Valid for Signing Requested by:  Patient MRN Date of Service Performing Facility Ordering Provider Result Provider Report Name :Surgical Report Right breast upper outer quadrant, needle aspirate b1opsy diagnosed as. fibrocystic change, proliferative ductal epithelium, fibrosis, and scattered inconspicuous atypical cells suspicious for lobular carcinoma. =INTRAOPERATIVE CONSULTATION: BPC DIAGNOsis: "(Smear) Lymph node positive for carcinoma" by Dr m GROSS DESCRIPTION: A. The specimen consists of the right breast, measuring 21 x 20 x 5.5 cm and weighing 1067 grams. No axillary tail is attached. No orientation is provided. The breast is covered with an ellipse of tan-white skin, measuring 17 x 7 cm. The nipple is retracted and measures 0.8 x 0.8 x 0.4 cm.  No discrete ulceration, fissure, or exudate is identified. The nipple is surrounded by unremarkable tan-brown areola. Approximately 2.2' cm away from the nipple is a poorly defined. slightly raised tan-brown area. measuring 0.7 x 0.6 cm. No discrete scar is identified. The deep surface reveals a large mechanica1 defect, measuring 5 x 2 cm and 3 cm in depth. The specimen appears to have been sectioned by the surgeon. The deep surface is inked black and the specimen is serially sectioned. The sections show a very poorly circumscribed. tan-white fibrotic area, measuring approximately 4.5 x 3.5. 3.5 cm. The fibrotic area reveals a well defined irregular mass, measuring 2.5 x 2.0 x 1.6 cm and a hemorrhagic area. measuring 0.7 cm in greatest dimension.  The mass is composed of tan-white firm tissue and is approximately 1.4 cm from the deep margin. One possible intramarmary lymph node, measuring 1.2 cm in greatest dimension. is identified. The lymph node is bisected and no discrete neoplastic involvement is present. The surgical resection margins are unremarkable. Separately received in the same container are five portjons of irregular tan-yellow adipose tissue. measuring 5 x 5 x 1 cm in aggregate. No discrete lesion or lymph node is identified in the separate portions. Representative sections are submitted in thirteen cassettes as follows: cassette 1 - mass with deep margin; cassettes 2 and 3 - additional section$ of mass: cassettes 4 through 6 - random sections from the fibrotic area, away. from the mass; cassettes 7 through 10 - sections from the four quadrants: cassette 11 - lymph node: cassette 12 - nipple and tan-brown area of the skin: cassette 13 - random sections from the separate portions. B/BPc. The specimen consists of one portion of tan-yellow adipose tissue. measuring 5 x 4 x 2 cm. The specimen has been bisected in pathology consultation. The specimen is serially sectioned and four possible lymph nodes.-ranging from Q.5 cm tq 2.5 cm) in greatest dimension. are identifred The two largest lymph nodes appear-to be involved by neoplasm. Representative sections are submitted in three cassettes as follows: cassette 1 - two intact lymph nodes; cassette 2 - one lymph node; cassette 3 - one lymph node. C. The specimen consists of multiple portions of tan-yellow adipose tissue.
+
+--- Page 3 ---
+Not for Permanent Storage in Medical Records / Not Valid for Signing Requested by: Patient MRN Date of Service Performing Facility Ordering Provider Result Provider Report Name :Surgical Report measuring 8 x 8 x 2 cm in aggregate. On palpation, fifteen possible lymph. nodes, ranging from 0.2_cm_tQ 1.5 cm in greatest dimension, are identified. Three lymph nodes are grossly involved by neoplasm. Representative sectiors are submitted in four cassettes as follows: cassette 1 - six intact lymph nodes: cassette 2 - one bisected lymph node: cassette 3 - .three lymph nodes; casca++? 4 - five intact lymph nodes. - MICROSCOPIC DESCRIPTION:: A, B/bpc, & C. Serial sections in twenty slides are examined. Sections from specimen A show breast within an extensively infiltrating mammary lobular carcinoma. focally with pleomorphic features. Tumor is widely infiltrative: closest approach to deep margin is approximately 9 mm.  Maximum tumor size [is difficult to assess on glass slides alone, but combining the grossly evidert tumor mass with the additional fibrotic areas, all of which are involved by carcinoma of the gross impression of up to 4.5 cm is felt to be accurate a$ a true assessment of the infiltrative tumor. The intramammary'lymph node. sampled in block Al1, as well as seventeen additional lymph nodes submitted as. parts B/sPc & C are all extensively involved by metastatic carcinoma  morphologically identical to the mammary primary. There is also evidence of extranodal spread involving the soft tissue surrounding several of the lymph nodes. T: -= FINAL DIAGNOSIS: = A, B/8PC & C.  RIGHT BREAST! MASTECTOMY WITH SENTINEL LYMPH NODE 8IOPSY AND FOLLOW UP AXILLARY DISSECTION: TUMOR TYPE: INFILTRATING CARCINOMA,  LOBULAR PHENOTYPE 1. 2.  NOTTINGHAM PROGNOSTIC INDEX/GRADE: II (TUBULE SCORE -3; NUCLEAR SCORE - 3: MITOTIC SCORE - 1) 3. MAXIMUM INVASIVE TUMOR SIZE: APPROXIMATELY 4.5 CM, GRQSS PLUS MICROSCOPIC DATA COMBINED; SEE DESCRIPTION 4. PERCENT DCIS: NOT APPLICABLE 5. LYMPHVASCULAR INVASION: NONE SEEN 6. DISTANCE TO CLOSEST MARGIN: 9 MM, DEEP. BLOCK A1 7. MICROCALCIFICATIONS: NOT APPLICABLE 8. LYMPH NODES: EIGHTEENOF: EIGHTEEN LYMPH NODES : INVOLVE$ BY METASTATIC CARCINOMA WITH EXTRANODAL SPREAD OF: TUMOR 9. TNM STATUS: pT3.N3a,MX 10.:  ANCILLARY. STUDIES:  IMMUNOHISTOCHEMICAL EVALUATION IS PENDING; AN ADDENDUM REPORT WILL BE
+
+--- Page 4 ---
+Not for Permanent Storage in Medical Records / Not Valid for Signing Requested by: Patient MRN Date of Service. Performing Facility. Ordering Proyider Result Provider Report Name :Surgical Report. ISSUED commFnt: The fine needle aspiration report from is reviewed in conjunctidn with the slides.. A-MAI TGNANT (Electronic S1gnature) DATE AND TIME OF REPURT:
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diff --git a/output/text/190a773b-6d22-4b35-8e56-6c5648a8b1c8.txt b/output/text/190a773b-6d22-4b35-8e56-6c5648a8b1c8.txt
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+Site cdu: bresot, N0s C50.9 1/7/1 h Patient Surg Path CLINICAL HISTORY: Locally advanced left breast cancer.. GROSS EXAMINATION: fibroadipose tissue measuring 3.5 x 2 x 0.9 cm in aggregate dimension. Sectioning reveals that each tissue fragment is composed of fibroadipose tissue with focal areas of firm, pink-tan poorly circumscribed tissue embedded in the adinose tissue. A portion of the specimen has been previously removed by Dr.  ind submitted for ER/pR evaluation. Tissue is sectioned and submitted in toto in Blocks Al and A2.. B. "Left axillary lymph nodes", in formalin. An irregular fragment of red-orange fibroadipose tissue measuring 2 x 1.2 x 0.9 cm within which is embedded a lymph node candidate measuring 1.1 x 0.5 x 0.5 cm in greatest dimension. The specimen is bisected and submitted in toto in Block B1. DIAGNOSIS: A. "LEFT BREAST BIOPSY": BREAST WITH INFILTRATING DUCTAL CARCINOMA, HISTOLOGIC GRADE 2, NUCLEAR GRADE 2. SKELETAL MUSCLE INVASION IS PRESENT. B. "LEFT AXILLARY LYMPH NODES": NODULES OF CARCINOMA ARE PRESENT BUT LYMPH NODES ARE NOT IDENTIFIED. UUID:EC8093CD-66E7-4466-99AD-B2A6B93526FD Redacted I of I
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diff --git a/output/text/192d6533-12ae-4df5-b562-9e009e26a72d.txt b/output/text/192d6533-12ae-4df5-b562-9e009e26a72d.txt
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index 0000000000000000000000000000000000000000..960a1031d41641f0102be5b2810abc21325b29f9
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+--- Page 1 ---
+UUID: 23B3BAED-E281-4A1D-AB78-51D8D62466FF TCGA-C8-A9FZ-01A-PR Redacted Clinical Case Report (For Collection of Cancerous Tissue) sireru rr, Lebikar,rnisehl. cipothi 20 (tbulnr). Informed Consent Es'Mreast. ce ntunl pertin cSo i I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the FORM with the patient and answered any questions the patient had. The patient then signed the. consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator Signature Date Clinical Information Date of Birth (mm/dd/yyyy) Height Marital Status Race Temperature  Single Married caucasian Weight  Divorced   Widow Gender Blood Pressure Heart Rate  Female Chief Complaints: Formation in the left mammary gland Symptoms: Formation in central portion of left breast 2,0 cm in diameter. Clinical Findings: Normal no complaints; no evidence of disease.. Performance Scale (Karnofsky Score):  60-70 Symptomatic, in bed less than 50% of day  100 Asymptomatic   80-90 Symptomatic but Fully Ambulatory  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden  20-30 Bed Ridden Route Frequency Date (mm/dd/yyyy) Drug Dose To To To To
+
+--- Page 2 ---
+HEAPASTMEDICAEHSTORYEHPEETKSRHA Diagnosis/Disease/Disorder/Injury Diagnosis Date Treatment Status Obesity gr.II Nephrolithiasis Menopausal Status Date of First Menses # of Pregnancies  Pre-menopausal 3  Peri-Menopausal Date of Last Menses # of Live Births  Post-menopausal pany Birth Control: Condom  Oral Contraceptive IUD  Hormone Replacement  Other: Therapy: Occupation: accountant Environmental Hazards: NO Smoking History Current Status TYPE Packs/day Duration When Quit  YES  nO (yrs)  (yr). Alcohol Consumption Current Status TYPE Drinks/day Duration When Quit  YES  nO (yrs)  (yr) Drug Use Current Status TYPE Frequency Duration When Quit  YES  nO (yrs) (y Diagnosis Age of Diagnosis Relative Result Date Test  Result Date Test HIV Negative CEA Negative Positive: Positive: Hep B Negative CA 15-3  Negative  Positive: Positive: Hep C  Negative CA 19-9   Negative  Positive: Positive: Negative AFP PSA  Negative  Positive: Positive: Other: Other:  Negative  Positive:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+R Study Results Date Ultrasound In the central portion of left breast - formation 2,0 cm in diameter X-Ray In the central portion of left breast -- tumor size 2,0 cm in diameter CT Endoscopy MRI Biopsy Breast cancer Preoperative Clinical Diagnosis Breast cancer Location of Suspected Involved Lymph Nodes Location of Suspected Distant Metastasis axillary Clinical Staging Date of Diaqnosis T2 N1 M0 Stage: IIB Treatment Information Procedure Date of Procedure Mastectomy with axillary and subclaian lymph node dissection Primary Tumor Organ Detailed Location Size Left breast Central portion 1.3x1.6x2.2 cm Extension of Tumor Lymph Nodes Description  Location of Lymph Nodes # of Lymph Nodes  Palpable, Non-Dissected Lymph Nodes  axillary, sublavian 10 Dissected Lymph Nodes Distant Metastasis Organ Detailed Location Size Surgical Staging T2N1M0 Stage: IIB Route Frequency Date (mm/dd/yyyy) Drug/Treatment Dose 4
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by: Date: `ime: Preserved by: Date: . 'ime: Frozen Paraffin Block Blood/Serum/Plasma Slide Diseased  Normal Diseased  Normal Diseased Normal Diseased  Normal 0 H 0 + + Time to LN2 Time to Formalin Time to LN2 15 min 15 min Primary Tumor Organ Size Extension of Tumor Distance to NAT Breast 1,3x1,6x2,2cm 2 cm Lymph Nodes Location # Examined # Metastasized axillary 5 3  subclaviculary 5 0 Distant Metastasis Organ Detailed Location Size Pathological Staging pT2N1M0 Stage:IIB Notes: 5
+
+--- Page 5 ---
+Consolidated Pathology Diagnosis + Struet Difuse  Strearming Mosaic Stor.orm Necrosis Lymphocytic Infirrationd seding Vascutar Invasion Orstic Degeneration Chusterized X Alveotar Formation Myxoid Charge Indnn Fle 1 wunornn/Caiciricationd +- stous + Snrcomnntoun + Lypdomatoues Scusamoid Cel Glanchutar ce. Round Ce Large Ce. Spindle Ce. Cell Stratirication V ibrottest Keratin ecretion O RS C rrS Lke Desrnosorme Intracyt. Vacux In Pear! Glond formation Lesma Ce.. Cenutar Diffe o We Moderate  Poor 0 1 Aniso Nudeosis EHtyperchromatism Nucieolar Prominent Multirwuc ed Glart Ce Miotic Activity. Nuciear Grade: Es D): 8Z Fina! Pathoiogy Reoort Tbuio-lobianCReAxxJ Comments D : 4 Date Director, Research Pathology 1.3/14 INTEGRATED REPORT OF FINDINGS BY COLLABORATORS ANDE PATHOLOGISTS - FO
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diff --git a/output/text/1956f8a3-74fd-4566-a55a-bdf1d45d1ec8.txt b/output/text/1956f8a3-74fd-4566-a55a-bdf1d45d1ec8.txt
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index 0000000000000000000000000000000000000000..c941953a80d5b4636db64aab419c38f450cc82ff
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+UUID:24B158B0-2477-4843-9CA8-467A8A IcD0-3 TCGA-V4-A9EX-01A-PR Redacted 87713 Ste s= RCuwsl cx9.s3 Enucleation of the right eye Y @1uexLtc Cb9.f QI Q|ie114 Macroscopy The eyeball mesures 27 mm main line with a segment of optic nerve of 7 mm. At the section, a pigmented tumor nodule is observed. Tissue specimens are taken for genetic studies and cryopreservation prior fixation. Microscopy The tumor nodule observed macrocopically presents the morphology of an uveal melanoma. This tumor is composed mainly of epithelioid cells, more rarely fusiform.. The cell atypias are severe. The pigmented load is mild. The mitotic activity is moderate. The tumor is at distance from the optic nerve which is free on its entire course. The ciliary body is also free. There is a focal tumor extension on the inner. third of the sclera, without extra-scleral exteriorisation. The cut end of the optic nerve is free. Conclusion Uveal melanoma, mainly composed of epithelioid cells. Tumor size: 15X15 mm main lines. Mitotic activity: moderate. Focal tumor infiltration of the 1/3 inner part of the sclera, without extra-scleral extension. Ciliary body, optic nerve on its entire course and optic nerve cut end free of tumor.
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diff --git a/output/text/19649d16-9426-48f1-b914-2ddb7287bd94.txt b/output/text/19649d16-9426-48f1-b914-2ddb7287bd94.txt
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index 0000000000000000000000000000000000000000..7272e9d56ec1ff8acf2d1089518774629b6595e4
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+UUID: F5EBC22F-D2D9-4944-9A24-390811798F5B TCGA-DG-A2K3-01A-PR Redacted Sample Type  TUMOUR Sample Preparation Fresh Frozen Site of Primary (Event) Cervical ICS-0-3 Site of Tissue cervix carcinona,psusmors cell Year of Sample Collection. MonKera#Nizng, N0S 8073/3 Age at Sample Collection (yrs). Sample Comments Site : Cerwix, N0s C53.9 Days to Procedure Date 0 lw 8fs3f1 Days to Diagnosis 18 Type of Procedure Surgical resection Site of Primary (Histology) Cervix Bilateral Disease NO Tumour Size (cm) 2.8999999999999999 Histology Squamous cell carcinoma, nonkeratinizing. Grade/Differentiation N/A Pathological T T1b  Pathological N N1 Number of Nodes Sampled 1 Number of Nodes Positive 23 Clinical M MO Histology Comments Possible lymphovascular invasion is seen. Report states grade 3/3. All resection margins are clear..
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diff --git a/output/text/1975e90f-3405-4bc2-87c1-ec974d1d0f63.txt b/output/text/1975e90f-3405-4bc2-87c1-ec974d1d0f63.txt
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index 0000000000000000000000000000000000000000..4b36853ed9338b133115cff3dbeb1010338679b2
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+UUID:2197BDCD-266C-4256-A18A-D0E8EAA63518 -A9TV-01A-PR Redacted CERVICAL LEFT LYMPH NODE: Lymph node of 2 x 1,2 x 0,6 cm. The cut surface is whitish and homogeneous. CERVICAL LymPH NODE, EXCISION: - PRIMARY MEDIASTINAL DIFFUSE LARGE B CELL LYMPHOMA Histological sections show a lymph node with a proliferation of atypical large. cells forming nodules which are separated by some fibrosis bands. The neoplastic cells have immunoblastic and Reed-Sternberg morphology,. forming clusters and extend to the perinodal adipose tissue. The large cells are positive for CD20, PAX5, and partially for CD30 and. CD23, and are negative for CD15. Several reactive T-cells are observed (CD3+ CD5+). The Ki67 proliferation index is 40%. The in situ hybridization for the Epstein-Barr virus (EBER) has been negative.. 1CD O 9k sc>|3 7yhnu Ote (77.) 4J 3/31/14 121s]3 42013
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diff --git a/output/text/19803684-2c5b-4d8c-8b36-4abed41e1255.txt b/output/text/19803684-2c5b-4d8c-8b36-4abed41e1255.txt
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index 0000000000000000000000000000000000000000..7fd63dd69fe14ca5e2fe2a45e36b5588f2ceaa32
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+Jed-u- Carcinoma, inifilfrating ductol, nos 8500/3 UUID:EAFC71A1-D6FC-46EA-BC47-D054C4970705 Site'bUuast, Nos TCGA-A2-A1FX-01A-PR c50.9 1/25/ Redacted SURQICAL REPORT Name:  Pathoiogy Number Sex: F Date Collected: ' DOB: Date Received: Location: M.R. Number Doctor. Account Number pre-operAtive DiagnOsis RIGHT SREAST CANCER post-oPerATive Diagnosis RiGHT BREASTS CANCER PROCEDURE Right sentine. Lymph nOde BiOpSy TISSUES A. LYMPH NODE (S) - SENT NODE #1 **FS** B. LYMPH NODE (S) - SENT NODE #2 **FS** C. BREAST EXCISION,NEEDLE LOC,SIMPLE,MARGINS,ETC. - RIGHT BREAST MASS D. AXILLARY - AXILLARY CONTENTS E. MARGINS - ADDITIONAL RIGHT BREAST TiSSUE F. MARGINS - ADDITIONAL LATERAL MAGINS WRI TISSUE - FS DIAGNOSISE A. Right sentinel Lymph node #1, f.s. - One positive lymph node (1/1). B. Fs not perFormed per dr. Derer. C. (Right sreast mass, f.s. - TUmOR MASS 4.7 Cm. AnD iNVOLVInG SUpERIOR, iNFERIOR, MeDial, AnterIor Surgical margins. TUmOR is ALsO VERy CLOse tO POsteRIOR AnD LATErAl SUrgiCAl mArginS (Wth small indurated noDules). E. ADDITiOnaL RIght BreASt tiSsUe (GrOss MArgiNs ONLy) LAteRal surgical mArgin is positive for malignancy. The RemAining surgical mArgins Are free Of tumOR. F. ADDItiOnAl LATerAl MArgin (GROss mArgins OnLy) - Surgical margin is free of lesion. Patlent Name: Pathology Number: SURGICAL REPORT Page 1 of 4
+
+--- Page 2 ---
+I...!ology Numbel Patlent Name (Time Raported to Surgeon:d FNal DiagNOsis A. Right senTinel Lymph node #1 - pOsITiVe fOR muLTiPpLe fOC! Of MEtAStATiC brEASt CANCER. B. Right SEnTINeL Lymph NODe #2 - POSITiVe FOR MetAstASiS, SUBCApSuLAR SinUs DEPOSITs MeAsuriNg LEss than 0.2 Mm. iN AggrEgate (1/1). c. Right breast mass - POsiTive fOr inFiLTrATing CARCinOMA MEAsuRinG 4.7 Cm. IN GreATESt DimeNSiOn with fOCAL ExTeNsiOn TO The SUpERIOR, iNfeRiOR AND meDiAL MArgiNs with eXtensiOn tO WThin % mm. Of The AnteriOr And LaTerAl Margins Resection. D. Axillary contents - POsitive fOr metAstAsis in four Of twenty TwO Lymph noDes, twO of fOur DiSpLAy subcApsuLAr MetAstAsis meAsuring mOre than 2 mm. in greAtest DimensiOn, One Of four DiSpLAys mIcrometAstAsis in suBcapsuLAr sinUs MEASURING ThAN 2 MM. AND REMAInInG ONE OF fOUR DiSPLAyS iSOLATED pOsitive cells In subcApsylAr sinuses (4/22). E. Additional right breast tissue -  POsitive for Additional carcinoma with tocal extension to the Lateral, . j. Anterior, superior and inferior surgical margins of Resection. F. ADdITIONal LATErAL MArgInS -S POsiTive fOr fOcAl extensiOn tO the new LAterAl Surgical margin oF rEsEcTion. PTNm CLASsIFIcATION: T2 N2s, MX, STage IIIA. ? Comment: This case is discussed with Dr.. The Cytokeratin (AE1/AE3) performed on specimen "B and D' support the diagnosls aiven. E-cadherin stain on speclmen "C" confirms the inflitrative duct carcinoma. (. Signature on file. PATHOLOGIST GROSS DESCRIPTION Pathology Number: Patient Name: ' Page 2 of 4 SURGICAL REPORT
+
+--- Page 3 ---
+Patient Named '..1ology Number The specimen is received in six separate containers labeled designated A, B, C, D, E and F. A. The container is received fresh unfixed labeled *right sentinel lymph node #1 for frozen section'. The specimen consist of an ovoid mass of pink-tan, trm, rubbery tissue with attached fat measuring 1.5 x 1 x 1 cm In greatest overall dimension. Touch prep and frozen section are obtained by Dr. The entire specimen, including trozen section, submitted in two blocks. B. The container is received fresh unfixed iabeied *right sentinel lymph node #2 for frozen section". The specimen consists of an ovoid mass of tan-gray, tirm, rubbery tissue with attached fat measuring 0.9 x 0.8 x 0.4 crn in greatest overal dimension. A touch prep is obtained by Dr. A frozen section Is not performed per Dr. . Entire specimen one block. C. The container is received fresh unfixed labeled *gross margins right breast mass". The specimen consists of an 18 gram ovoid mass of apparent fatty and fiber incased. ovoid mass which is 5.5 x 3 x 2 cm in greatest overali dimension. There is an Inserted Indicator wlre. There is an attached single suture indicating anterior margin inked with a blue dye. Posterior is inked with a black. There are two short sutures Indicating superior margin inked with a red dye. Inferior is inked with a yellow. There is a long suture indicating lateral margin Inked with an orange. Medial is inked with a green. Gross margins are observed by Dr. He states tumor mass is 4.7 cm and invoving superior, inferior, medial, anterior, surgical margins. Tumor mass is very close to the posterior and lateral surgical margin, with small indurated nodules. The specimen is submitted in twelve blocks. Key note block summary: 1- superior, 2 -- Inferlor, 3 -- anterior, 4 -- posterior, 5 -- Iateral, 6 -- medial. All of those are perpendicular. 7 through 12 -- remaining. D. The container is received fresh unfixed labeled *exillary contents*. The specimen consists of an irregular mass of apparent fatty tissue measuring 10 x 8 x 3 cm in greatest overall dimension. Serial sectioning reveals firm, purple-tan noduies varying up to 0.9 cm in greatest dimension. The entire specimen is submitted in five blocks. E. The container is received fresh unfixed for gross margins which are obtained by Dr. labeled *additional right breast tissue". There is a single short suture indicating anterior margin inked with an orange dye. Deep margin is inked with a black dye. There are two short sutures indicating superior margin inked with a red dye. Inferior is inked with a yellow. There is a single long suture indicating lateral margin inked with a green dye. Medal is inked with a blue. Sectioning reveals frm nodules varying up to 4 cm in greatest dlmension. Latera/green margin is grossly positive. These nodules are chiefly located in the anterior lateral area and approximately 0.2 cm from the anterior margin. The specimen Is submitted in nine blocks.. Key note block summary: 1 -- Iateral, 2 -- medial, 3 -- anterior, 4 -- deep, 5 -- superior, 6 - inferior, 7 through 9 -- random. F. The container is received fresh unfixed labeled "additional lateral margins -- suture on new lateral margin which is inked with a green dye. Gross margins are obeerved by Dr.  Sectloning reveals firm palpable nodules varying up to 0.3 cm in greatest dimension. They appear to be 0.4 cm from the new lateral margin. The specimen is subnitted as four sections in four blocks. Patient Name:d Pathology Number: SURGICAL REPORT  Page 3 of 4
+
+--- Page 4 ---
+Patlent Name: MICROSCOPIC EXAM  Mcroscopic examination conDucteD by pathologist confirms final Diagnosis. SPECIAL STAINS PERFORMED: E-Cadherin (speclmen C); Cytokeratin (AE1/AE3) (specimens B and D) Primary Tumor Site Discrcpang HIPA: Discrepancy Dual/synch Patient Name Pathology Number: Page 4 of 4 SURGICAL REPORT
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diff --git a/output/text/199785fe-2f8a-4458-ba9a-8b0fcc012c76.txt b/output/text/199785fe-2f8a-4458-ba9a-8b0fcc012c76.txt
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+
+--- Page 1 ---
+UUID:E991576A-60BD-4C11-9B4E-EA43F19D06C3 TCGA-DD EB-01A-PR Redacted CLINICAL DIAGNOSIS: Hepatocellular carcinoma suggested Specimen : Liver and Liver mass. Gross Photo : GROSS: Specimen status: Fresh Operation: Partial hepatectomy and cholecystectomy Organs: Liver (17.0 x 7.0 x 4.2 cm, 254.5 gm) and gallbladder (9.1 cm in length and 2.0 cm in diameter) Lesion: A well-defined round mass (4.7 x 4.0 x 3.7 cm) in liver. Cut surface: Yellowish to green solid and firm mass without necrosis Gross type: HCC: Expanding nodular Resection margin: Not involved grossly (safety margin: 2.0 cm). Others: Satellite nodule: No Remaining parenchyma: Periportal fibrosis (stage 2), mild steatosis. r-03 Gross photo: Present Cereirtnis hegaturelOelos NOS Blocks 317013 T1-4,TB, mass x 5 Sute: xiuer Cax.O NB, L, liver parenchyma x 2 RM, resection margin x 1 Qs 8/20/14y GB, gallbladder x 1 MICROSCOPIC: Hepatocellular carcinoma: Yes The worst differentiation II The major differentiation II Histologic type: Trabecular Cell type: Hepatic Fatty change: Yes (10%) Fibrous capsule formation: Partial capsule. Capsular infiltration: Yes Septum formation: No Surgical resection margin invasion: No, safety margin (2.0 cm). Serosal invasion: No Portal vein invasion: No Microvessel invasion: No Intrahepatic metastasis: Unknown. Multicentric occurrence: Unknown. NOT reported. Gross:
+
+--- Page 2 ---
+Liver, needle, consistent with, hepatocellular carcinoma. Liver, ectomy, hepatocellular carcinoma, moderately differentiated, steatosis, periportal fibrosis T56000, P10, M81703, moderately differentiated, M50080, periportal fibrosis. Gallbladder, ectomy, chronic cholecystitis. T57000, P10, M43005 Lymph node, regional, biopsy, reactive hyperplasia T08000, regional, P50, M72200 DIAGNOSIS: Liver, partial hepatectomy:. Hepatocellular carcinoma, moderately differentiated Steatosis, mild Periportal fibrosis (stage 2) Gallbladder, cholecystectomy: Chronic cholecystitis Lymph node, regional, biopsy: Reactive hyperplasia (0/1). Suggestion :
\ No newline at end of file
diff --git a/output/text/19a08a62-c99f-414d-bacd-8ada157caf00.txt b/output/text/19a08a62-c99f-414d-bacd-8ada157caf00.txt
new file mode 100644
index 0000000000000000000000000000000000000000..41d9dde77c54d5d26672b9386d15ec08379154da
--- /dev/null
+++ b/output/text/19a08a62-c99f-414d-bacd-8ada157caf00.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UUID:A7FAA4F2-1846-48CF-9FB5-15E98430F6CE TCGA-C8-A274-01A-PR Redacted IRB APPROVED MultI-media systems, Inc. Form Revised Clinical Case Report /ch-0-3 (For Collection of Cancerous Tissue) Criter! cartrma, mifiltreting duct,Nos 85oof3 Site: Drenst nos C50.9 hw 5T2ufu Informed Consent I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Date Name of Physician or Study Coordinator Signature Clinical Information SSGENERALINFORMATIONS Marital Status Race Temperature Date of Birth (mm/dd/yyyy) Height 37*c Single I  Married dDivorced  Blood Pressure Heart Rate Gender Weight  Widow 13o78swo 1h R Ym  Male Female THISTORYOF PRESENTILLNESS Chief Complaints: f h<int 2nuH, ago Symptoms: Hmd a hmi 7le Aiyht Oadet muminbl hur Performance Scale (Karnofsky Score):  60-70 Symptomatic, in bed less than 50% of day.  100 Asymptomatic  80-90 Symptomatic but Fully Ambulatory  20-30 Bed Ridden  40-50 Symptomatic, in bed more than 50% of day. but not bed ridden. L CURRENT MEDICATIONS: Date (mm/dd/yyyy) Dose Route Frequency Drug To To N To To To
+
+--- Page 2 ---
+ PAST MEDICAL HISTORY. Status Treatment  Diagnosis Date Diagnosis/Disease/Disorder/Injury OBGYNHISTORY* # of Pregnancies Date c ' First Menses  Menopausal Status # of Live Births  Pre-menopausal Date of Last Menses  Peri-Menopausal  Post-menopausal  Hormone Replacement  Oral Contrac-.ive  IUD Therapy: Birth Control:  Condom  Other: ESOCIAL HISTORYA T Environmental Hazards: Occupation: Smoking History When Quit Duration  Packs/day (yr) TYpe (yrs) Current Status  yes.. nO Alcohol Consumption When Qult Duration  Drinks/day (yr) TYPE (yrs) Current Status  yes sNO Drug Use When Quit Duration Frequency Type. (yrs) Current Status DYES pNO MPKSLEAMILYMEDICAL HISTORYAEP Age of Diagnosis  Diagnosis  Relative MRbdy lcs caue Date CAAMRLABDATAER   Result Test Date  Negative  Positive: Result CEA Test  Positive: Negative  Positive: CA 15-3   Negative HIV  Positive: Negative  Positive:  CA 19-9   Negative Hep B   Negative  Positive:  Positive:  Negative PSA Hep C  Positive:  Negative Other: AFP  Negative  Positive: Other:  Positive:  Negative B/T Cell Markers: 2
+
+--- Page 3 ---
+PS*DIAGNOSTIC STUDIES.: Results Date Study Ultrasound X-Ray CT Endoscopy MRI Biopsy +HTSCLINICAL DIAGNOSISTT*  Preoperative Clinical Diagnosis Cauer Location of Suspected Distant Metastasis Location of Suspected Involved Lymph Nodes Axilla M Date of Diagnosis Clinical Staging Stage: PR T2 m : Treatment Information SURGICAE TREATMENTEMMAS Date of Procedure Procedure Datey's swrreu Primary Tumor Size. Detailed Location Organ Cmex x cm Breurt Extension of Tumor Lymph Nodes # of Lymph Nodes Description Location of Lymph Nodes 5 AnllA Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Size Detailed Location Organ NO Surgical Staging m J Stage: T 2 N o  NEOADJUVENTTHERAPY (Chemo, Radiation, Immuno, Hormonal, or Molecular)   Date (mm/dd/yyyy)  Route  Frequency Dose Drug/Treatment 1 To To 1 NO 1 To / To To / 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Date: Collected by Date. -  ime: Preserved by:  Slide wsSPECIMENTYPE (#ofsamplesprovided (Blood/Serum/Plasma  Paraffin Block Diseased  Normal Diseased Normal Frozen Normal  Normal Diseased Diseased X x  Time to LN2 Time to Formalin Eo. min  Time to LN2 min min SAOPATHOLOGICAL DESCRIPTIONAO.*. Primary Tumor  Distance to NAT Extension of Tumor  Size 2. cn Organ. 9.5x x cm Lymph Nodes # Metastasized # Examined Location Axill NR Distant Metastasis Size Detailed Location  Organ Pathological Staging Stage: RA Mo pT 9 No Notes: 4
+
+--- Page 5 ---
+COnSOLIDaTED DIAGnOsTIC pAThOLOgy fORm* Microscopic Appearance: Histological pattern: 1. CELL DISTRIBUTION Diffuse + STRUCTURAL PATTERN +- X] Streaming Mosaic x Storiform Necrosis Fibrosis Lymphocytic Infiltration X Vascular Invasion Palisading X Cystic De:eneration Clusterized Bleeding Alveolar Formation Myxoid Change Indian File x Psammoma/Calcification 2. Cellular features. Sgwam ows. +-Adcnomatous +I - Sarcomatous + Lymphomatoys Squamoid Cell Glapdular cel! Round Cell Large Cell Spindle Cell Cell Stratification Fibrobiast Small Ceul  Keratin Secretion Osteoblast RS CeIV/RS Like  Desmosome Intracyt. Vacuole Lipoblast Inflam. Cell Pear! Gland formation Myoblast Plasma Cell Otherwise Specified: 0j7oZ Dq6r7 0>60 2. Cellular Differentiation: Well Moderatcly Poor 4 Nuclear Atypia: Nuckear Appearance Aniso Nucleosis Hyperchromatism Nucleolar Prominent k Multinucleated Giant Celil Mitotic Activity Y Nuckear Grade Histological Diagnosis: InhttnaKny Aattal Ca nsnrety /s, Cor 2 Comments Date Director, Researclr Patsotogy PATHOLOGIST STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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diff --git a/output/text/19a56e2e-6d07-4e61-8ff4-a62064d2b42e.txt b/output/text/19a56e2e-6d07-4e61-8ff4-a62064d2b42e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..65620c92cf8e31f60a37dc0719ab08d6b0e416e3
--- /dev/null
+++ b/output/text/19a56e2e-6d07-4e61-8ff4-a62064d2b42e.txt
@@ -0,0 +1,30 @@
+
+--- Page 1 ---
+UUID:3D84D02A-42B1-42E1-84FB-E9AE9381ABB4 TCGA-OL-A66H-01A-PR Redacted Sample # FINAL PATHOLOGIC DIAGNOSIS A. Lymph node, right sentinel #1, excision: - Lymph node with several micrometastases, largest measuring 0.5 mm in extent (1/1) B. Breast, right central, partial mastectomy: - Invasive ductal carcinoma, grade II/Ill with mucinous features, 1.9 cm in  greatest dimension, focally involving nipple/areolar complex, surgical margins widely free (see pathologic parameters below). - Previous biopsy site identified C. Skin, lateral and medial corners of incision, excision:. -Skin and underlying breast tissue with no significant histopathologic changes IgDs-3 arcndne;mucnouo 848s/3 Site B Y3uastNss C5s9 sl6|3 9D Breast Pathologic Parameters 1. Invasive carcinoma: A. Gross measurement: 1.9 cm. B. Composite histologic (modified SBR) grade: II/III 2. Excisional biopsy margins: Free of tumor - Invasive carcinoma >2.0 cm from all surgical margins. 3. Blood vessel and lymphatic invasion: Present in breast parenchyma 4. Axillary lymph nodes:
+
+--- Page 2 ---
+- One sentinel lymph node with several foci of micrometastases (1/1) - Size of largest metastatic deposit: Approximately O.5 mm - Extranodal extension: Absent 5. Special studies: - ER: Strong expression in >90% of invasive tumor nuclei - PR: Strong expression in >80% of invasive tumor nuclei - Her2/neu antigen (FISH): Pending 6. pTNM (AJCC, 7th edition, 2010): pT1c, N1mi, MX Effective this Checklist utilizes the 7th edition TNM staging system for breast of the American Joint Committee on Cancer (AJcC) and the International Union Against Cancer (UIcC) Comment Her2/neu (FisH) is pending and will be reported as an addendum. Interpretation performed by the Attending Pathologist and reviewed with the  Resident/Fellow, M.d. Electronically Signed Out by PROCEDURE/ADDENDA Addendum
+
+--- Page 3 ---
+Date Ordered: Status: Signed Out Date Completed: Addendum Diagnosis RECEIVED FROM Breast Cancer Assay Description Breast Cancer Assay uses RT-PCR to determine the expression of a. panel of 21 genes in tumor tissue. The Recurrence Score is calculated from the gene expression results. The Recurrence Score range is from O-100. Results Breast Cancer Recurrence Score = 6 The findings summarized in the Clinical Experience sections of this report are applicable to the patient populations defined in each section. It is unknown whether the findings apply to patients outside these criteria.. Clinical Experience: Prognosis for node negative, ER-positive patients. The Clinical Validation study included female patients with Stage I or Il, Node Negative, ER-Positive breast cancer treated with 5 years of tamoxifen. Those patients who had a Recurrence Score of 6 had an Average Rate of Distant Recurrence of 5% (95% CI: 3%-7%) Quantitative Single Gene Report.
+
+--- Page 4 ---
+ER Score = 11.4 Positive PR Score = 7.9 Positive HER2 Score = 9.5 Negative Laboratory Director: ORIGINAL REPORT ON FILE IN SURGICAL PATHOLOGY LABORATORY Addendum Comment A request for molecular studies was received on from Dr. The test is to be performed on tissue from case The case report, slides and blocks for the cited accession were retrieved from archives. The  pathologist whose signature appears below reviewed the original pathology report, examined candidate H&E slides, and selected block B5) and forwarded it to . where the subject molecular test will be performed. An addendum report will be issued when the results of this molecular test are available.
+
+--- Page 5 ---
+Addendum Date Ordered: Status:Signed Out Date Completed: Addendum Diagnosis RECEIVED FROM HER2 Amp, Breast Cancer, FiSH Specimen Tissue-Paraffin Specimen ID Source Right breast. Order Date Reason For Referral. r/o HER2 gene amplification Fixative Formalin METHODS: FISH using probes for HER2 (17q12) and a chromosome 17 Centromere (D17Z1) control probe . Two technologists score signals in 60 Total nuclei from invasive or metastatic tumor and Concurrent controls.  Results Nuc ish(D17Z1,HER2)x2
+
+--- Page 6 ---
+The HER2:D17Z1 ratio is 1.03. Average HER2 signals per nucleus is 1.8. Average D17z1 signals per nucleus is 1.7. Interpretation The invasive tumor nuclei have no evidence of HER2 gene Amplification (per AScO/CAP guidelines) in this breast Excision specimen. The HER2:D17Z1 ratio is 1.03. This result suggests the tumor has two chromosomes 17 with a Normal HER2 gene copy number. ASCO/CAP reporting guidelines (Wolff et al., Arch Path Lab Med 131: 18-43, 2007): A HER2:D17Z1 ratio less than 1.8 indicates absence of HER2 gene amplification. A HER2;D17Z1 ratio from 1.8 2.2 is equivocal for HER2 Gene amplification.. A HER2:D17Z1 ratio greater than 2.2 indicates HER2 gene Amplification when there are greater than 6 HER2 signals per nucleus. DISCLAIMER: This test was developed and its performance Characteristics determined by It is intended as an.
+
+--- Page 7 ---
+Adjunct to existing prognostic clinical and pathologic Information for breast cancer patients. This test is not Intended to diagnose or screen for breast cancer. Per ASCO/CAP guidelines, HER2 FISH test results are valid for Non-decalcified paraffin embedded specimens fixed in 10% Neutral buffered formalin between 6 and 48 hours. Results From specimens fixed outside these parameters should be Interpreted accordingly. Consultant Report Date *Performing Site: ORIGINAL REPORT ON FILE IN SURGICAL PATHOLOGY LABORATORY
+
+--- Page 8 ---
+Clinical. History: The patient is a -year-old female with breast cancer undergoing lumpectomy. Specimens Received: A: Right sentinel node #1. B: Right breast central partial mastectomy; lumpectomy C: Additional tissue from lateral and medial corners of incision Gross Description: The specimens are received in three containers each labeled with the patient's name and medical record number.. A. The first container is additionally identified as, 'right sentinel node #1'. Received fresh and placed in formalin is a 1.4 cm rubbery, bluish discolored lymph node that is bisected and submitted in A1. B. The second container is additionally identified as, 'right breast central partial mastectomy'. Received fresh and placed in formalin is a 90.2 gm partial mastectomy specimen measuring 7.3 cm from medial to lateral, 7.8 cm from superior to inferior and 3.3 cm from anterior to posterior. There is a 6 x 4.8 cm areola with a 1.3 x 1 cm flat nipple, with a short suture designating the superior pole and a long suture designating the lateral pole. The specimen is
+
+--- Page 9 ---
+inked as follows: anterior - black posterior - red superior - blue inferior - green medial - yellow lateral - violet The specimen is serially sectioned from medial to lateral into 9 slices (slice 6 at nipple). There is a solid, white-tan, retroareolar mass located in slices 6-7 measuring 1.9 x 1.8 x 1.2 cm. It is located 2.4 cm from the superior margin, 2.5 cmfrom the lateral margin, 3.0 cm from the inferior margin, 3.3 cm from the medial margin, and 3.5 cm from the deep margin. Representative sections are submitted as follows: B1: Medial margin B2: Lateral margin B3-B9: Slice #7, lesion and margins B10-B11: Representative skin and nipple, slice #6 B12: Representative uninvolved, slice #5 B13: Representative uninvolved, slice #8 Tissue fixed for at least 6 hours in 10% NBF and no more than 72 hours.
+
+--- Page 10 ---
+C. The third container is additionally identified as, 'additional tissue from Iateral and medial corners of incision'. Received fresh and placed in formalin are 2 pieces of skin and subcutaneous tissue. One piece measures 4 x 2.3 x 0.5 cm and has a stitch that designates the medial corner; this margin is inked blue, and the remainder is inked black. The other portion of skin measures 3.8 x 2.8 x 0.8 cm; the deep surface is inked black. The specimens are sectioned and no discrete lesions are identified. Representative sections are submitted as follows: C1: Representative sections of piece with stitch C2: Representative section of other piece , M.D. Pathologist Sign Out: 4124
\ No newline at end of file
diff --git a/output/text/19a8f09c-d64b-4d5b-8118-a45c33994765.txt b/output/text/19a8f09c-d64b-4d5b-8118-a45c33994765.txt
new file mode 100644
index 0000000000000000000000000000000000000000..510b1dec5b88212c98a31fee5319edde95ad126f
--- /dev/null
+++ b/output/text/19a8f09c-d64b-4d5b-8118-a45c33994765.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+FcDt3 Cecum C18.D Site Report 9J 4/1o/3 SURGICAL PATHOLCGY IRGICAL PATHOLOGY UUID:E997748F-FB20-4CF3-8621-96618187AF2E TCGA-QG-A5Z2-01A-PR Redacted PORT Accession No. RIgHT hEMICoLECToMy BRIEF CLINICAL HISTORY: PREOPERATIVE DIAGNOSIS: colon cancer OPERATIVE FINDINGS: POSTOPERATIVE DIAGNOSIS: colon cancer Surgeon/physician: PATHOLOGY REPORT Labo atory Accession No GrOSS DesCRIpTIOn: The specimen consists of a 27.8 cm in length segment of right colon with 4.7 cm of attached terminal ileum. The specimen is stapled at both ends with a moderate amount of attached fat. The serosa is tan-pink to red, smooth and glistening. There is a 7.2 x 0.8 cm intact vermiform appendix. Opening reveals a tan-brown smooth glistening ileal mucosa with normal folds. The ileocecal valve is tan-yellow and thickened. The colonic mucosa displays a 3.8 x 2.6 x 0.8 cm tan-red slightly raised polypoid mass that is 9.3 cm from the proximal resection margin, and 19.8 cm from the distal resection margin.  Sectioning through the mass reveals a focal area of invasion going into the underlying muscle layer. The mass does not extend to the inked serosal surface. The mass is 7.3 cm from the mesenteric resection margin. The remaining colonic mucosa is tan-brown smooth and glistening with a 1.0 x 1.0 x 0.3 cm submucosal mass grossly consistent with a. submucosal lipoma. There is a moderate amount of endoscopy tattooing adjacent to the polypoid mass. Sectioning through the attached fat reveals multiple tan-pink rubbery lymph nodes. Representative sections are submitted as follows: l- proximal resection margin; 2- distal resection margin; 3-9- entire mass with underlying fat and possible inked serosa; 10- mesenteric resection margin closest to mass; 11- submucosal lipoma; 12- appendix; 13- ileocecal valve; 14-18- multiple whole lymph nodes; 19-20- one bisected lymph node in each; 21- multiple whole lymph nodes. MICROSCOPIC EXAM DIAGNOSIS: Colon, right, hemicolectomy: INVASIVE ADENOCARCINOMA, LOW GRADE (MODERATELY DIFFERENTIATED), (SEE CANCER SUMMARY) ALL MARGINS FREE OF TUMOR  23 LYMPH NODES NEGATIVE FOR MALIGNANCY (O/23)
+
+--- Page 2 ---
+ TATTOO PIGMENT IDENTIFIED  UNREMARKABLE APPENDIX - SUBMUCOSAL LIPOMA Surgical Pathology Cancer Case Summary SPECIMEN:  Terminal ileum, cecum, appendix, ascending colon PROcEDuRE: Right hemicolectomy TUMOR SITE: Cecum TUMOR SIZE: 3.8 x 2.6 x 0.8 cm MACROSCOPIC TUMOR PERFORATION: Not identified HISTOLOGIC TYPE:  Adenocarcinoma HISTOLOGIC GRADE: Low grade (moderately differentiated). MICROSCOPIC TUMOR EXTENSION:  Tumor penetrates into the muscularis propria MARGINS: Proximal:  Uninvolved by invasive carcinoma Distal: Uninvolved by invasive carcinoma Mesenteric: Uninvolved by invasive carcinoma. TREATMENT EFFECT: No prior treatment LYMPH-VASCULAR INVASION: Not identified PERINEURAL INVASION: Not identified TUMOR DEposITs: Not identified LYMph noDes: 0 metastases (23 nodes examined) PATHOLOGIC STAGING: (pTNM): pT2, pNO, pMx) PATHOLOGIST Signed Eno y/2y13
\ No newline at end of file
diff --git a/output/text/19c8f8e8-c77e-4cc1-aed1-9a301a227032.txt b/output/text/19c8f8e8-c77e-4cc1-aed1-9a301a227032.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b4d05aeab0550aaed6c1c52f7eda34258d224e74
--- /dev/null
+++ b/output/text/19c8f8e8-c77e-4cc1-aed1-9a301a227032.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Path (First Tumor) Tumor Site: Cecum Proximal Date of Cancer Sample Procurement: Histology: Adenocarcinoma Description of other histology: Grade: Moderately Differentiated 3  Yes r No  Yes C Unknown Mucinous: (Focal) ( Yes Signet Ring Feature:  No C Yes C Unknown (Focal) Histologic Heterogeneity:. 6 No r Yes r Unknown Host Response: Lymphoid Aggregates Crohn's like reaction. ( None  Yes C Unknown Plasma cell rich stroma C No C Yes C Unknown  Expansile  Expansile Growth Pattern: ( Invasive ~ Unknown and Invasive Inflammatory Bowel Disease r No C Yes  Unknown Angiolymphatic Invasion:  No  Yes r Unknown Mutator Phenotype: r No  Yes  Unknown Number of Slides 1 C Yes Garland Necrosis present: r No  Yes r Unknown (Focal) TIL Cells / HPF Pathologist Comment: JCs-0-3 adurocxrioms,/muciions, Nvs 848of3 UUID:E332DBF8-FC70-4848-9595-45B295D69885 S1te: Cecum c18.s hs 5|3|n TCGA-DM-A288-01A-PR Redacted DSQUANE
\ No newline at end of file
diff --git a/output/text/19dcee72-b1a1-4fab-85ff-4873213f1317.txt b/output/text/19dcee72-b1a1-4fab-85ff-4873213f1317.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4b06105e7ae13c1b5d697306b9ea0e3051f6f0e2
--- /dev/null
+++ b/output/text/19dcee72-b1a1-4fab-85ff-4873213f1317.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis: Resected colon sample with two moderately differentiated, invasive adenocarcinoma of the colorectal type, measuring max 5 cm in diameter, both with infiltration of the pericolic. fatty tissue. Two local lymph node metastases. Tumor-free colon resection margins.. Tumor-free mesenteric resection margin. The tumor stage is: pT3, (2), pN1 (2/33) pNX; G2, L0, V0, local R0.
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diff --git a/output/text/19f6f9f1-e91e-4745-af4d-391c75f75715.txt b/output/text/19f6f9f1-e91e-4745-af4d-391c75f75715.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a56b2a245c009caf42f8f07d6050ab1af58ac9e5
--- /dev/null
+++ b/output/text/19f6f9f1-e91e-4745-af4d-391c75f75715.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Clinical Diagnosis & History year old male with kidney mass,(right. Specimens Submitted: 1:SP:Kidney,right,nephrectomy 2:SPLymph nodes,right precaval and paracaval, excision DIAGNOSIS: SP:Kidney,right, nephrectomy Tumor Type: Renal cell carcinoma-Chromophobe type Tumor Size: Greatest diameter is 11 cm. Local Invasion (for renal cortical types): Involves renal sinus fat Renal Vein Invasion: Not identified Surgical Margins: Free of tumor Non-Neoplastic Kidney: Exhibits patchy chronic interstitial inflammation and fibrosis,and glomerular sclerosis. Adrenal Gland: Not identified Lymph Nodes: Not identified Staging for renal cell carcinoma/oncocytoma: pT2 Tumor >7.0 cm in greatest dimension limited to the kidney Comment: Prominent nuclear atypia is present. 2. SP:Lymph nodes,right precaval and paracaval, excision: Lymph Nodes: Not involved Number of nodes examined:1 Page 1 of2
+
+--- Page 2 ---
+IATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL).AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT Gross Description: 1).The specimen is received fresh, labeled "right radical nephrectomy" and consists of a kidney with attached ureter,renal vessels and perinephric fat weighing 771 g in total.The kidney measures 12 x 7 x 6 cm.The attached ureter measures 8.5 cm in length and 0.2 cm in diameter.The attached renal vein measures 0.2 cm in length and 0.5 cm in diameter. The renal vessels and ureter margins are grossly unremarkable. An adrenal gland is not identified. The kidney is inked black and bivalved to reveal a 11 x 9 x 7 cm necrotic, lobulated yellow and hemorrhagic mass in the lower pole extending to the mid kidney and renal pelvis. The mass entirely replaces the lower portion of the kidney. The mass grossly extends to the renal capsule but does not penetrate through it. The mass appears to extend into the perihilar fat. Sections through the remainder of the kidney reveal a pink-brown parenchyma,with a well-defined cortico-medullary junction.The cortex measures 0.2 cm and the calyces appear normal. No lymph nodes are identified in the perinephric fat.Representative sections are submitted for TPS and for permanent sections. Summary of sections: UVM-- ureteral and vessel margins Ttumor THF-- tumor with hilar fat TK-- tumor with adjacent kidney RP-- renal pelvis representative sections K--representative sections kidney TC-tumor with capsule 2). The specimen is received in formalin, labeled "Right precaval and paracaval lymph nodes" and consists of a single brown-tan fleshy lymph node measuring 7 x 1 x 0.6 cm.The lymph node is trisected and entirely submitted. Summary of sections: T-trisected lymph node Summary of Sections: Part 1:SP:Kidney,right,nephrectomy Block Sect.Site PCs 1 k 1 1 rp 1 9 t 9 2 tc 2 3 thf 3 1 tk 1 1 uvm 1 Part 2:SP:Lymph nodes,right precaval and paracaval,excision Block Sect.Site PCs 3 T 3 Page2of2 END OFREPORT
\ No newline at end of file
diff --git a/output/text/19fef4ef-5f14-40a8-b743-498aec03574a.txt b/output/text/19fef4ef-5f14-40a8-b743-498aec03574a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3d927272a6aa6a1ee358cba99e8b045c5bd57d2d
--- /dev/null
+++ b/output/text/19fef4ef-5f14-40a8-b743-498aec03574a.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+TCGA-D5-6530 page 1 / 1 Department of Cancer Pathology. Examination: Histopathological examination. Material: 1. Multiple organ resection -- cancer of the caecum -- right half of the colon with the distal part of the ileum Physician in charge: Material collected on Material received on: Expected time of examination: Clinical diagnosis: Cancer of the caecum - right half of the colon with the distal part of the ileum Examination performed on Macroscopic description: 30 cm length of the large intestine with a fragment of the mesentery sized 17 x 19 x 5 cm, a 9 cm segment of the small intestine, and the appendix of 6 cm in length. Cauliflower-shaped, ulcerous tumour in the mucosa sized 4.5 x 4 x 1 cm. The lesion surrounds 100% of the intestine circumference and narrows its Iumen, is situated 12 cm from the proximal cut line and 20 cm from the distal cut line. The lesion macroscopically invades through the periintestina! tissue. Minimum side margin is 4 cm. Microscopic description: Adenocarcinoma tubulare (G2). Infiltratio carcinomatosa tunicae muscularis priopriae. Intestine ends free of neoplastic lesions.. Lymphonodulitis reactiva No XV.. Examination result: Adenocarcinoma tubulare coli. Tubularadenocarcinomatof the colon?. (G2, Dukes A, Astler - Coller B1, pT2, pN0).
+
+--- Page 2 ---
+Histopathological diagnosis: Adenocarcinoma mucocellulare partim tubulare et mucinosum invasivum ventriculi. Mucocellular and  partially tubular and mucinous invasive adenocarcinoma of the stomach. Metastases carcinomatosae in lymphonodorum (No Xvil/xx). Cancer metastases of the lymph nodes (No XVI1/XX) {G3, pT2, pN3}
\ No newline at end of file
diff --git a/output/text/1a01adf5-85fc-4e32-9570-0b412a3d6ec2.txt b/output/text/1a01adf5-85fc-4e32-9570-0b412a3d6ec2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..93558053284f9482248d120bdfc30d2c20e0017d
--- /dev/null
+++ b/output/text/1a01adf5-85fc-4e32-9570-0b412a3d6ec2.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UUID:A2BA1C88-630C-42B0-97E2-B58E22AC8EB3 TcgA-CF-A8Hy-01A-PR Redacted IRB APPROVED Clinical Case Report. CiCE tcdo. (For Collection of Cancerous Tissue) C areunims, srstkilial caAl NOS 8/zo/3 Cerenom, tiarsitionolcool 8i3o J3 pap.iLsrej S.t: Informed Consent sadiler NBS C67 9 I personally informed this patient that a specimen(s) would be collected to be used fof'research. purposes. I reviewed the.  RESEARCH SUBJECT INFORMATION AND CONSENT lvj|/z6!3 FORM with the patient and answered any questions the patient had. The patient then signed the. consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator Signature Date Clinical Information GENERAL INFORMATION Date of Birth (mm/dd/yyyy) Height  Marital Status Race Temperature Single Married Gender Weight  Divorced  Widow  Blood Pressure Heart Rate Male  Female HISTORY OF PRESENT ILLNESS Chief Complaints: Di fhiclf t wvinate j bloc( cs5 l^vre j j?cu'n Symptoms: weight loss Clinical Findings: Performance Scale (Karnofsky Score):  100 Asymptomatic  80-90 Symptomatic but Fully Ambulatory $0-70 Symptomatic, in bed less than 50% of day  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden ..  20-30 Bed Ridden. CURRENT MEDICATIONS Drug Dose Route Frequency Date (mm/dd/yyyy) To / To 1 To 1 1 To 1 ! To
+
+--- Page 2 ---
+PAST MEDICAL HISTORY Diagnosis/Disease/Disorder/Iniury Diagnosis Date Treatment Status OB/GYN HISTORY  Menopausal Status Date of First Menses # of Pregnancies  Pre-menopausa!  Peri-Menopausal Date of Last Menses # of Live Births  Post-menopausal Birth Control:  Condom  Oral Contraceptive   IUD  Hormone Replacement  Other: Therapy: SOCIAL HISTORY Occupation: Environmental Hazards: Smoking History. Current Status TYPE Packs/day Duration When Quit O yES  qNO (yrs) (yr) Alcohol Consumption Current Status TYPE  Drinks/day Duration When Quit Idouk ldeu. 20 (ys) 6mo($sagw) YES nO Drug Use Current Status TYPE Frequency Duration When Quit  YES SNO (yrs) ( FAMILY MEDICAL HISTORY Relative Diagnosis Age of Diagnosis LAB DATA Test  Result Date Test Result Date HIV ANegative  Positive: CEA  Negative  Positive: Hep B Negative  Positive: CA 15-3   Negative  Positive: Hep C Negative  Positive: CA 19-9   Negative  Positive: AFP  Negative  Positive: PSA   Negative  Positive: Other: Other:  Negative  Positive:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+DIAGNOSTIC STUDIES Study Results Ultrasound  A t-mwk Wc fowd Date  the .bladh X-Ray CT Endoscopy MRI Biopsy CLINICAL DIAGNOSIS  Preoperative Clinical Diagnosis URas bloddee Gncel Location of Suspected Involved Lymph Nodes. Location of Suspected Distant Metastasis. Clinical Staging. Date of Diagnosis T2 Ng MD Stage: Treatment Information SURGICAL TREATMENT Procedure Date of Procedure Pesecticro Primary Tumor Organ Detailed Location Size Bedeer fecaop. Qiekppisg lesen 3x2 cm Extenslon of Tumor/ Lymph Nodes Description Location of Lymph Nodes # of Lymph Nodes Paipable, Non-Dissected Lymph Nodes. Dissected Lymph Nodes Distant Metastasis Organ  Detailed Location Size Surgical Staging T? no. M o Stage:  NEOADJUVENT THERAPY (Chemo, Radiation, Immuno, Hormonal, or Molecular) Drug/Treatment Dose Route Frequency Date (mm/dd/yyy) To To 1 To / To 1 1 To 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by: - Date: : Time: Preserved by: -.. Date: .Time: SPECIMEN TYPE (# of samples provided) Frozen Paraffin Block Blood/Serum/Plasma Slide Diseased Normal Diseased Normal Diseased Normal Diseased Normal A 2 2. 2 Time to LN2 Time to Formalin Time to LN2 min /3 min min PATHOLOGICAL DESCRIPTION Primary Tumor Organ Size Extension of Tumor Distance to NAT Irinaets bleddee cm Lymph Nodes Location # Examined # Metastasized Distant Metastasis Organ Detailed Location Size Pathological Staging pT 2 mO Stage: 17/  Notes:
+
+--- Page 5 ---
+IRB AppROVED Consolidated Pathology Diagnosis. ID#: . Cell Distribution + Diffuse Structarai Pa ttern  Streaming  Mosaic.  Storform  Necrosis Fibrosis L mohoctic Inftrationd Palsading. Vascustar Invasion C'stic Degenera tion Clusterized Bleedirng. Alveotar Formation  M xoid Change Inxdian File  Psammoma/Cakcinicationd Sgssn smouzs +- Aderyorsatousn +I- Sarcomatous Sguarnokd Cel! + Ls m ohomatous Gtarcduiar cen Round Cel! Laroe Cel Soindle Cell Cel Stratification. Fibroblast Senal Cel Keratin Secretion Osteobiast Desmosome  rs Cea/rs Like Intrac't. Vacuole Lipobiast Infiam. Cell Pear! Slard formeton Myoblast Cellular Differentiation: Plasma Cel o Weil Moderate  Poor Nacseor At ypin: Aniso Nucleosis 0 Hyperctromatism Nudeotar Prominent Muttinucieoted Glart Ce X Mitotic Activity Nuciaar Grade: X  py907 Fina! Pathology Report Pas'lapy toasxiboral Histologica! Diagnosis: Grade: cei carenni Comments: Director, Research Pathologyd Date INTEGRATED REPORT OF FINDINGS BY COLASORATORS AND PAA Discrepar ase is jcin ALITED DSC
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diff --git a/output/text/1a1e630d-05c9-4e7e-bed7-856d01c756d8.txt b/output/text/1a1e630d-05c9-4e7e-bed7-856d01c756d8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..cfbf2467fd1d74fce8497489d13fa731a550d4e8
--- /dev/null
+++ b/output/text/1a1e630d-05c9-4e7e-bed7-856d01c756d8.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+TCGA--BP--4795 Accession #: Dale of Procedure: Date of Recelpt: Date of Report: Account #: Bllling Type: Additional Copy to: Rof. Source: Clinlcal Diagnosis & History:. Ith right renal mass incidentally found. Specimens Submitted: 1: SP: Right kidney; nephrectomy. 2: SP: Lymph nodes, paracaval; excision DIAGNOSIS: SP: Right kidney; nephrectomy. Tumor Type:  Renal celf carclnoma - Conventional (clear cell) lype. Fuhman Nuclear Grade: Nuclear grade II/IV Tumor Size: Greatest dlameter is 1.5 cm. Local Invasion (for renal cortical lypes): Not ldentified Renal Vein invasion: Not identified Surglcal Margins: Free of lumor Non-Neoplaslic Kidney: Marked glonerulosclerosis and chronic pyelonephritis. Adrenal Gland: Not submitted Lymph Nodes: Not Identlfled Staging for renal cell carcinoma/oncocytoma: pT1 Tumor <= 7.0 cm In greatest dimension limited to the kidney. Comment:  The tumor has "clear cell-papillary features" as has been described in kidneys with inipaired renal function. 2.SP: Lymph nodes, paracaval; exclslon. Lymph Nodes; Not involved Number of nodes examined:2 Page 1 of 2
+
+--- Page 2 ---
+1ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL. EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Special Studles: Result Special Stain Comment RECUT Gross Description: 1). The specimen is received fresh labeled "right kidney' and consists of a kidney with attached ureter, renal vessels and perinephric fat weighing 150 g In total. The kidney measures 8 x 5 x 3.5 cm. The attached ureter measures 3 cm in length and 0.3 cm in diameter. No adrenal gland is identlfied. The kidney is inked black and bivalved to reveal a well circumscribed tan. nodule in the upper pole, ineasuring 1.5 x 1.3 cm on cross-section. The tumor replaces the renal coriex, reaches but does not penelrate to the renal capsule, and pelvis. The renal parenchyma in the upper pole is brownish necrotic, with an ill defined. corlicomedullary junction. The renal parenchyma in the lower pole is relatively preserved. The cortex In this ares measures 0.4 cm. No lymph node is identified. The entire tumor is submitted. TPS is taken. Representative sections are submitled. Summary of sections: UVM -- ureterol and vessel margins T-. tumor UK -- representatlve sections of upper pole kidney  LK -- representative sections lower pole kidney F -- fot 2.) The speclmen is recelved in formalln, labeled "paracaval lymph nodes" and consists of multiple ploces of flbroadipose tissue measuring 3.8 x 3.3 x 1.8 cm in aggrogate. Within this tissue, two lymph nodes are identifled measuring 1.3 and 0.6 cm in greatest dimenslon. The Iymph nodes are entirely submitted. Summary of sections: LN - lymph nodes Summary of Sections: Part 1:  SP: Right kidney; nephrectomy Block Sect. Site PCs 1 F 1 1 LK 1 5 T 5 1 UK T 1 UVM 1 Part 2:$P: Lymph nodes, paracoval; excislon Block Sect. Site PCs 1 LN 1 Page 2 of 2 END OF REPORT
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diff --git a/output/text/1a7799c0-b96b-43a6-b8da-22e11c830ba8.txt b/output/text/1a7799c0-b96b-43a6-b8da-22e11c830ba8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..42210d8ba32179f19dfe087e7ecf47226711f5cf
--- /dev/null
+++ b/output/text/1a7799c0-b96b-43a6-b8da-22e11c830ba8.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+IcD-6- 3 Carc moma, Infiltrahig FINAL PATHOLOGIC DIAGNOSIS ductal UsS 8600/3 A. Left axillary sentinel lymph node #1; biopsy: SiFc O Breas+N0S c509 - Two lymph nodes, no tumor (0/2) LO q[18]13 B. Left axillary sentinel lymph node #2; biopsy: UUID:927C0D4A-327A-4168-80C7-151A48865CC9 TCGA-OL-A5RZ-01A-PR Redacted - One lymph node, no tumor (0/1) C. Left breast; simple mastectomy: - Invasive ductal carcinoma, SBR grade Ill arising in a background of ductal carcinoma in situ, high nuclear grade, solid type, with central necrosis See parameters. - Uninvolved breast parenchyma with rare microcalcifications associated with benign acini and focal apocrine metaplasia Breast Pathologic Parameters 1. Invasive carcinoma: A. Microscopic measurement: 7mm B. Composite histologic (modified SBR) grade: III - Architecture: 3 - Nuclear grade: 3 - Mitotic count: 2 C. Associated intraductal carcinoma in situ (Dcis): present - Intermediate and high nuclear grades, solid type with central necrosis - Extent of DCIS microscopically is consistent with the 10.2 x 5.4 x 3.5 cm of non-mass like enhancement seen radiographically.
+
+--- Page 2 ---
+2. Excisional biopsy margins: Free of tumor - Invasive carcinoma >1cm from closest margin - Dcis 8mm from anterior margin, superior aspect 3. Blood vessel and lymphatic invasion: Absent 4. Nipple and skin: Unremarkable 5. Skeletal muscle: Absent 6. Axillary lymph nodes: Negative (0/3) 7 Special studies (invasive component, current specimen) - ER: weak expression in 30% of cells - PR: no expression - Ki-67: 10-20% - HER2 (FISH): pending 8. pTNM (AJCC, 7th edition, 201O): pT1b, NO(sn), MX Clinical History: The patient is a  -year-old female who presented with an abnormal screening mammogram on that revealed a large area of pleomorphic calcifications biopsied as ductal carcinoma in situ, high grade, solid type with central necrosis. Left breast MRI on evealed segmental clumped non-mass enhancement with mixed kinetics measuring 10.2 x 5.4 x 2.5 cm associated with a Iateral biopsy clip. A 0.7 x 1.0 x 1.0 cm mass with washout kinetics, suspicious for invasive component was seen just posterior to the biopsy clip. The patient undergoes simple mastectomy, sentinel lymph node biopsy and breast
+
+--- Page 3 ---
+reconstruction. Specimens Received: A: Left sentinel lymph node #1 B: Sentinel node #2 left axilla. C: Left breast Gross Description: The specimens are received in three containers each labeled with the patient's name and medical record number. A. The first container is additionally identified as, 'left sentinel node #1'. Received fresh for intraoperative diagnosis is a 4.0 x 2.0 x 1.0 cm segment of tan-pink fibrofatty tissue that is dissected for lymph node candidates. Frozen section diagnosis is 'lymph node, no tumor' per. . The frozen section. remnants are entirely submitted in cassettes A1 FS and A2 FS. The remaining tissue is entirely submitted in cassettes A3 and A4.. B. The second container is additionally identified as, 'sentinel node #2, left axilla'. Received fresh for intraoperative diagnosis is a 3 x 2.0 x 2.0 cm segment of tan-brown rubbery tissue grossly consistent with a lymph node. The
+
+--- Page 4 ---
+cut section reveals an unremarkable surface. The entire lymph node is frozen :. The frozen Post section diagnosis is 'lymph node, no tumor' for. section remnant is entirely submitted in cassette B1FS. c. The third container is additionally identified as, 'left breast'. Received. fresh and placed in formalin is a 2640 gm mastectomy specimen measuring 32.5 cm from medial to lateral, 32.5 cm from superior to inferior and 5.3 cm from. anterior to posterior. There is 80 cm long by 0.7-6.5 cm wide tan-brown, wrinkled skin ellipse on the anterior surface, with ashort suture designating. the superior pole and a long suture designating the lateral pole. The areola  measures 5.5 x 3.5 cm areola and the nipple 1.5 cm in diameter. The nipple areolar complex displays no evidence of ulceration or retraction. No axillary tail is present with the specimen. The deep surface is inked black, the  anterior-superior surface blue and the anterior-inferior surface green and the breast is serially sectioned from medial to lateral into 11 slices. There is a. 1.1 x 0.9 x 0.8 cm, gray-tan mass in slices 7 and 8, 5.5 cm from black ink and 2.0 cm from blue ink. A metallic clip is identified in slice 7. A 1.5 cm (greatest dimension) biopsy site is identified, adjacent to the lesion, with a  probable metallic clip (vs. staple) within the node. Additional masses or nodules are not noted. Representative sections are submitted as follows:. C1-8: Representative sections of lesion, slice 7 and 8 (clip in C1, C3 closest approach to blue ink). c9: Intramammary lymph node, adjacent to mass, bisected C10: Representative slice 6, medial to mass.
+
+--- Page 5 ---
+C11: Representative slice 9, lateral to mass. C12: UOQ, slice # 10 C13: UIQ, slice # 3 C14: LOQ, slice # 9 C15: LIQ, slice # 2 C16: Representative skin C17-18: Nipple Tissue fixed for at least 6 hours in 10% NBF and no more than 72 hours.
\ No newline at end of file
diff --git a/output/text/1a8f7ef0-a98d-4cb6-bf29-8ae170b90472.txt b/output/text/1a8f7ef0-a98d-4cb6-bf29-8ae170b90472.txt
new file mode 100644
index 0000000000000000000000000000000000000000..455b33e9c7fa1eee1da9985ea8b2bfcde56abddb
--- /dev/null
+++ b/output/text/1a8f7ef0-a98d-4cb6-bf29-8ae170b90472.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Surgical Pathology Report Name: Case #: DOB: Collected: Gender: Received: MrN: Reported: Location: Copy To: Physician: Pathologic Interpretation: A. Sentinel node #1( ) right FS: /cs-0-3 - Metastatic carcinoma into one lymph node (1/1) Carcinmn,mfltnuhig9 duchl,nps 85oc/3 Sentinel node #2 1 )Fs: - Metastatic carcinoma into theree out of four lymph nodes (3/4) St : srenot, Nos C50.9 3/f h C. Sentinel node #3( }Fs: - One benign lymph node (0/1) D. Right breast lumpectomy, long - lateral, short - superior:.  - In situ and invasive carcinoma - The entire tumor mass measures 2.3 cm in greatest dimensions - The invasive component represents the majority of the tumor mass and is of Nottingham grade of 3 +3 +3=9/9 - Foci of vascular invasion are noted. - The in-situ component is of ductal type, high nuclear grade with central necrosis and calcifications (comedocarcincma) - All margins of resection appear free of invasive and intraductai carcinoma - The closest margins of resection are the medial and anterior at 4 mm from the tumor - The non-neoplastic breast tissue shows fibroproliferative disease, radial scar, atypicai ductal hyperplasia and changes consistent with prevlous biopsy site D. Right axillary content: - Metastatic carcinoma into six out of twenty-thre lymph nodes (6/23) E.Level 3 (right) permanent: - Metastatic carcinoma into one out of three lymph nodes (1/3) UUID: AE0C51EF-017E-4F53-968C-804110F9A7E60 TCGA-EW-A1P1-01A-PR Redacted Tumor Summary: Specimen Type Lumpectomy Lymph Node Sampling: Axillary dissection. Specirnen Size (for excisions less than total mastectomy): 6 cm in greatest dimensions Laterality: Right. Tumor Site: Not specified Size of Invasive Component: 2.3 cm in greatest dimensions Histologic Type: Ducta! Histologic Grade (any grading system may be used; mitotic count is also required independent of the grading system)| 3 +3 +3=9/9 Total Nottingham Score:9/9 Margins: Free Pathologic Staging (pTNM) pT 2, N3, MX
+
+--- Page 2 ---
+SURGICAL PatHOL Report ID5-ER.PgR 636-PR.A4RS-HER2.H-EGFR.AI pathologist as pozitive or negalive. As the attending pathologist, I attest that I: (i) Examined the relgvant preparation(s) for the specimen(s): and (ii) Rendered the diagnosis(es). ***Electronically Signed Out By*** Intraoperative Consultation A. Sentinel node #1 (. , right FS: Metastatic adenocarcinoma to one lymph node (1/1). B. Sentinel node #2(  FS: Metastatic adenocarcinoma to three of four lymph nodes (3/4) C. Sentinel node #3 ( ) FS: One lymph node, no tumor seen (0/1). MD Clinical History: None provided. Qperation Performed Right breast lumpectomy with sentinel node blopsy, possible axillary node dissection; possible left breast reduction. Pre Qperative Diagnosis: Breast cancer Specimen(s) Received: A: Sentinel node #1  rnight FS B: Sentinel node #2 (: )Fs C: Sentine! node #3? )FS D: Right breast lumpectomy, long - lateral, short - superior E: Right axillary content F: Level 3 (right) permanent. Gross Description: A.  Received fresh is an irregular fragment of nbroadipose tissue, measuring 2.3 x 1.2 x 0.7 cm. One lymph node is il-. defined. The lymph node is submitted in toto in one cassette for frozen section. 8. Received fresh is an irregular fragment of fbroadipose tissue, measuring 3.2 x 1.7 x 0.9 cm. Four lymph nodes are. grossly identified. The lymph nodes are submitted in toto as follows: One lymph node for frozen. 2 Lymph node for frozen soction. c. Received fresh is an irregular fragment of fibroadipose tissue, measuring 1.9 x 1.1 x 0.7 cm. One lymph node is grossly identified. The lymph node is submitted in toto in one cassette for frozen section. D.  Received in formalin is a lumpectomy specimen measuring 6 cm from medial to lateral, 5.4 cm from superiorto inferior and 4.4 cm from anterior to posterior. The specimen has an ellipse of skin in the anterior surface measuring 3.8 x 0.9 cm. The specimen is labelled as follows: long stitch laterai; short stitch superior. The margin is inked as follows: Anterior. yellow, posterior black, superior blue, inferior green, medial red, lateral orange. Upon sectioning ill-defined fitm white and  Page 2 of 3
+
+--- Page 3 ---
+SURGICAL PATHOL Report tan mass is identified measuring 2.3 x 2 x 1.5 cm. The mass is 1 cm from the lateral margin up to 1.6 cm from the  superior margin, 0.5 cm from the inferior margin, 0.5 cm from the posterior margin, 0.4 cm from the media margin and 0.4 cm from the anterior margin from the skin. Other areas of the mastectomy specimen show unremarkable ibroadipose tissue. Representative sections are submitted as follows: 1 Lateral margin. 2  Superior margin 3 Anterior margin and skin in relation with the tumor 4  Medial margin in relation with the tumor 5 Posterior margin in relation with the tumor 6 Inferior margin in relation with the tumor 7-8 Other areas of the mass E.  Received in formalin are multiple irregular fragments of fibroadipose tissue measuring 9 x 7.5 x 2.2 cm in aggregate. Five---> possible lymph nodes are identified. The lymph nodes are submitted in toto---> as follows: 1-2 'One lymph node bisected per cassette 3-4 Lymph node bisected per cassette 5-6 Three lymph nodes bisected per c assette 7-8 Four tymph nodes per cassette F.  Received in formalin are four irregular fragments of soft tan brown and yellow tissue measuring 1 x 0.5 x 0.4 cm in aggregate. Submitted in toto in one cassette. 3/71 Page 3 af 3
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diff --git a/output/text/1a9b6f4f-682c-495d-a055-3fcbaa01a27c.txt b/output/text/1a9b6f4f-682c-495d-a055-3fcbaa01a27c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ad8afec1d2669c56e82bc41325387a2eff5c8bdd
--- /dev/null
+++ b/output/text/1a9b6f4f-682c-495d-a055-3fcbaa01a27c.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+/e0-0-3 Cusciomn, dluctl Nos, mnfitet'rg 85o0/3 Sil Crdli: busot, nOS C 50.9 1/17/n Patient: Surgical Pathology: Final-- Surg Path CLINICAL HISTORY: Not provided by surgeon. Status post mammogram with calcifications in right UoQ and prominent tracer accumulation in both breasts on bone scan (Dhis). GROSS EXAMINATION: A. "Right/breast biopsy". The specimen is a piece of breast tissue measuring 3.0 x 3.0 x 4.0 cm with a 2.0 x 1.3 cm. tan well-lobulated well-circumscribed mass.  Blocks are submitted as follows: Block Al - Remnant of frozen section "AFi". Blocks A2 through A8 - Multiple sections of the biopsy comprising. nearly the entire specimen. B. and relatively small axillary tail. The anterior aspect of the breast is inked in black ink, and the posterior or deep aspect in blue ink. Overall, the specimen is 27.0 x 16.3 cm. with the breast measuring 19.5 x 16.3 cm. and. the axillary tail measuring 7.0 x 6.0 cm. in greatest dimensions.  The skin ellipse is 15.4 x 7.4 cm. with a 4.0 cm. semi-circular incision immediately superior to the nipple. This incision is sutured together with black suture material. On serial sectioning, the breast has a large white fibrous mass immediately deep to the nipple. In the anterior aspect of this mass is a 2.3 x 2.0 cm. biopsy cavity that is slightly hemorrhagic. The dense fibrous tissue is not grossly involved with the margins and extends laterally 6.0 cm. from the biopsy cavity. Examination of the axillary tail reveals seven lymph nodes in Region I, four lymph nodes in Region II, and five lymph nodes in Region III. Blocks are submitted as follows: Blocks B1 through B5 - Deep surgical margins from superior aspect. to inferior. Block B6 - Medial biopsy cavity. Block B7 - Additional surgical margin with grossly close surgical margins.. Block B8 and B9 - Lateral biopsy cavity. Blocks B10 and B1l - Inner upper quadrant. Blocks B12 and B13 - Inner lower quadrant. Blocks B14 and B15 - Upper outer quadrant. Blocks B16 and B17 - Lower outer quadrant. Block B18 - Section through biopsy scar. Block B19 - Section through nipple. Block B20 - Four lymph node candidates from Region I.. Block B21 - Three lymph node candidates from Region I,.  the largest being bisected and inked in blue ink.. Block B22 - Three lymph node candidates from Region II, the largest being bisected and inked in blue ink.. Block B23 - One lymph node candidate from Region II, bisected.. Block B24 - Four lymph node candidates from Region III. Block B25 - One lymph node candidate from Region III, bisected.. INTRA OPERATIVE CONSULTATION: Frozen section diagnosis AFl: "Right breast biopsy - INFILTRATING CARCINOMA." MICROSCOPIC EXAMINATION:S Other changes seen in the breast include focal florid usual hyperplasia, interlobular fibrosis, papillary apocrine metaplasia, and cystically dilated. ducts. DIAGNOSIS: UUID:55F3F917-E441-4C10-A3E3-0645A4E8374E TCGA-B6-A0IA-01A-PR Redacted eBrowser Result for.
+
+--- Page 2 ---
+"RIGHT BREAST BIOPSY": A. BREAST TISSUE WITH CRIBRIFORM INTRADUCTAL AND INFILTRATING DUCTAL CARCINOMA; N.S.A.B.P. NUCLEAR GRADE - MODERATELY-DIFFERENTIATED, THE TUMOR MEASURES 2.O CM. IN GREATEST DIAMETER. B. "RIGHT BREAST": BREAST WITH PREVIOUS BIOPSY SITE, NO RESIDUAL CARCINOMA IS SEEN. NO TIMOR IS SEEN IN FIFTEEN AXILLARY LYMPH NQDES. Verified by: (Electronic Signature) Date Signed: eBrowser Result for: 2 of 2
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diff --git a/output/text/1a9cd5a7-7f77-4fd0-a3f3-288f049912de.txt b/output/text/1a9cd5a7-7f77-4fd0-a3f3-288f049912de.txt
new file mode 100644
index 0000000000000000000000000000000000000000..45c44984fd7b784543d6a517a4222b83a158a450
--- /dev/null
+++ b/output/text/1a9cd5a7-7f77-4fd0-a3f3-288f049912de.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+zCD -o -3 Carcinomc-, Adrenal Cortcal UUID:A898F0C7-9596-4DF1-9784-CAACFAB672D8 TCGA-OR-A5LL-01A-PR 8370/3 Redacted Sste; B Adrenol Glaud, Cortex C740 9tJ a/e13 Procedure: Right adrenalectomy and Right nephrectomy Gross Description: Adrenal tumor is 172g; measuring 9 x 7 x 5cm. There is a 0.7cm nodule in the right kidney with granulomatous cells and gigantic cells; possibility of tuberculosis is raised. Diagnosis: Adrenal cortical carcinoma. Weiss score = 7. No LN mets (+0/10). No invasion of renal artery. s/p cholecystectomy ---> chronic inflammatory changes.
\ No newline at end of file
diff --git a/output/text/1aad23a2-4546-4993-bef3-402632965429.txt b/output/text/1aad23a2-4546-4993-bef3-402632965429.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a63f0f415e81961ebdf4d501cf8f83d7ab5523d4
--- /dev/null
+++ b/output/text/1aad23a2-4546-4993-bef3-402632965429.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+Clinical Diagnosis & History: Core biopsy of left breast shows infiltrating carcinoma with FNA of node positive for carcinoma. Right mastectomy is prophylactic. Specimens Submitted: 1: sp: Right breast 2: sp: Left breast and axillary contents levels 1 and 2. 3: sp: Sentinel node #1 level'i right axilla 4: sp: Additional left breast upper flap tissue. ep DIAGNOSIS: 1) BREAST, RIGHT; PROPHYLACTIC MASTECTOMY: - BENIGN BREAST TISSUE WITH FLORID SCLEROSING ADENOSIS, FOCAL DUCTAL HYPERPLASIA WITHOUT ATYPIA, SECRETORY CHANGES, CYSTS, FISROADENCMATOID CHANGES AND A FEW MICROCALCIFICATIONS. - UNREMARKABLE NIPPLE. 2) BREAST AND AXILLARY CONTENTS LEVELS 1 AND 2, LEFT: MODIFIED RADICAL MASTECTOMY AND AXILLARY LYMPH NODE DISSECTION: - INVASIVE DUCTAL CARCINOMA, HISTOLOGIC GRADE II-III/III, NUCLEAR GRADE III/III, ASSOCIATED WITH LYMPHOCYTIC INFILTRATE AND MEASURING 1.9 CM IN LARGEST DIMENSION MICROSCOPICALLY. - A MINOR COMPONENT OF DUCTAL CARCINOMA IN SITU (DCIS). SOLID AND MICROPAPILLARY TYPES WITH HIGH NUCLEAR GRADE AND NECROSIS. IS PRESENT ADMIXED WITH AND AWAY FROM THE INVASIVE CARCINOMA. - NO INVOLVEMENT OF THE NIPPLE, SKIN OR THE SURGICAL MARGINS BY CARCINOMA IS IDENTIFIED.  LYMPHOVASCULAR INVASION IS PRESENT. - THE NON-NEOPLASTIC BREAST TISSUE SHOWS PREVIOUS BIOPSY SITE CHANGES, FLORID SCLEROSING ADENOSIS, DUCTAL HYPERPLASIA WITHOUT ATYPIA AND A BENIGN INTRADUCTAL PAPILLOMA. E/098 - THE LYMPH NODE STATUS IS AS FOLLOWS (EXPRESSED AS THE NUMBER OF POSITIVE) LYMPH NODES IN RELATION TO THE TOTAL NUMBER OF LYMPH NODES EXAMINED): "erfe! LEVEL I: 0/8 LEVEL II: 1/7 THERE IS FOCAL EXTRANODAL EXTENSION OF CARCINOMA (>2 MM) AND PERINODAL VASCULAR INVASION. - RESULTS OF SPECIAL STAINS (ER, PR, HER-2/NEU) WILL BE REPORTED AS AN) ADDENDUM. ** Continued on rext page ** b'050 -0-401
+
+--- Page 2 ---
+Page 2or LYMPH NODE, SENTINEL #1 LEVEL 1 RIGHT AXILLA; BIOPSY:S - ONE BENIGN LYMPH NODE (O/1). - ADDITIONAL H/E LEVELS AND CYTOKERATIN (AEI:AE3) IMMUNOSTAINS ARE ALSO NEGATIVE FOR METASTATIC TUMOR.S 4) SOFT TISSUS, ADDITIONAL LEFT BREAST OPPER FLAP; EXCISION:S - ADIPOSE TISSUS, NEGATIVE FOR TUMOR. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. *. Report Electronically Signed Out Special studies: Result Special Stain Comment er-c PR-C hER2-C NEG-HER2 NEG CONT IMM RECUT er-c PR-C ER-c pr-c HER2-C NEG-HER2 NEG CONT IMM RECUT AE1:AE3 NEG CONT IMM RECUT Gross Description: 1) The specimen is received fresh. labeled -Right breast. Stitch marks axillary tail". It consists of a breast measuring 18 x 17 x 5 cm overlaid by white-tan skin, measuring 10 x 4.5 cm. There is a centrally placed, slightly inverted nipple, measuring 1.2 cm in diameter, surrounded by an uaremarkable arcola, moasuring 4 cm in diameter. Cross-sectioning of the specimen reveals dense fibroid tissue in the central portion of the Specimen, but no discrete mass is identified.. taken. Summary of Sections:. N - Nippla NB - Nipple base DM - Deep margin ** Continued on next page *.
+
+--- Page 3 ---
+FT  Fibroadipose tissue LIQ - Lower inner quadrant LOQ Lower outer quadrant urQ Upper inner quadrant OQ Upper outer quadrant 2) The specimen is received fresh, labeled "Left breast and axillary contents. levels 1 and 2 (2 specimen tags attached)". It consistn of a breast measuring 16 x 16 x 5.5 cm, with an axillary tail measuring 10 x 7 x 1.6 em. The axillary tail has 2 tags designating levels 1 and 2. The The is a centrally placed, everted nipple, measuring 1.o cm in diameter, surrounded by unremarxable areola, measuring 4 cm in diameter. Cross-sectioning of the specimen reveals a firm to hard, fairly circumscribed, centrally placed mass, measuring 1.7 x 1.5 x 1.5 cm, approximately 1.0 cm from the deep margin. Ti is surrounded by dense fibrous tissue. The mass, arbitrarily designated cm anterior to T1 is a mass measuring 1.0 cm in diameter and approximately 4 Approximately 5 cm lateral and 3 cm from the deep margin. The second mass. which is arbitrarily designated T2, has a central cavity filled with necrotic material grossly. remainder of the breast tissue consists of unremarkable fibroadipose tissue. Examiaation of the axillary tail show several lymph nodes at levol 1. The ranging from 0.5 cm to 2.0 cm and at level 2 ranging from 0.5 cm to 2.5 cm. The smaller lymph nodos are submitted in toto. The largest lymph nodes are bisected, alternatively inked and submitted eatirely. Summary of Sections: N - Nipple NB - Nipple base FT - Fibrous tissue. DM - Deep margin Ti - Centrally-placed mass. I cm to the deep margin T2 Laterally-placed mass LIQ - Lower inner quadrant LOQ Lower outer quadrant UIQ  - Upper outer quadrant LNI Level I lymph node 3LNI - Bisected level I lymph node. 3LLni - Bisected largest ievel 1 lymph node LN2 - Level 2 lymph node 3LLN2 - Bisected largest ievel 2 lymph node. 3) The specimen is received in formalin, labeled *Sentinel node #1. level 1. right axilla". Ic consists of an apparent lymph node, measuring 1.2 x 1.0 x 0.5 cm, surrounded by pink-tan, unremarkable adipose tissue, measuring 1.0 x 1.0 x 0.2 cm. toto, in addition to the surrounding fibroadipose tissue. The lymph node is bisected and submitted in Summary of Sections: Continued on next page *
+
+--- Page 4 ---
+SLN  Sentinel lymph node 4 4 0f 5 4) The specimen is received in formalin, labeled -Additional lest breast measuring 4 x 3 x 0.5 cm. Cross-sectioning of the specimen reveals grossly unreuarkable adipose tissue. The specimen is entirely submitted.. Surmary of Sections: FA - Fibroadipose tissue Summary of Sections: Part 1: SP: Right breast Block Sect. Site 1 PCs 8 cm. 1 fa 7 liq 1 R H r d 1oq ? nb uiq 2 rt yog Part 3: SP: Left breast and axillary contonts lavels I and 2. Block Sect. Site 1 blln1 PCs 2 blln2 1 2 1 bln1 2 bln2 H2 1 dm fa ri N 1 1iq 2 lni 1 1 1n2 1 loq nb H 1 3 t1 H m t2 uiq 2 uoq Part 3: SP: Sentinel node #1 level 1 right axilla. Block Sect. Site 1 PCs sin 1 * Contiaued on next page 3
+
+--- Page 5 ---
+SP: Additioaal left brea  flap tissue  Page 5 of 5 Block Sect. Site PCs f3 Procedures/Addenda: Addendum Date Ordered: Date Complete: Status: Signed Out Date Reported:. By: Addendum Diagaosis ADDENDUM REPORTS SITE: LEFT BREAST (PART #2) ER: 0% NUCLEAR STAINING PR: 0% NUCLEAR STAINING HER-2/NEU (HERCEPTEST) :  POSITIVE (STAINING INTENSITY OF 3+) CONTROLS ARE SATISFACTORY * End of Report
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diff --git a/output/text/1affd6fe-2774-4de3-b1b5-935e11117399.txt b/output/text/1affd6fe-2774-4de3-b1b5-935e11117399.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e1673b853cdcc7116589e361a65da5b17a8ba82a
--- /dev/null
+++ b/output/text/1affd6fe-2774-4de3-b1b5-935e11117399.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis / Diagnoses: 1.: Right hemicolectomy specimen, under inclusion of a centrally ulcerated, moderately differentiated adenocarcinoma of the colorectal type and of a maximum of 3 cm in length, with infiltration of the pericolic fat tissue. No regional lymph node metastases. Tumor-free resection margins and tumor-free omental fat tissue. 2.: Moderate chronic fibrosing cholecystitis with chronic fibrosing pericholecystitis and cholecystolithiasis. Tumor stage: pT3 pN0 (0/23) pMX; G2
\ No newline at end of file
diff --git a/output/text/1b0979d6-d7a9-405d-a7e9-39dc58cf03ff.txt b/output/text/1b0979d6-d7a9-405d-a7e9-39dc58cf03ff.txt
new file mode 100644
index 0000000000000000000000000000000000000000..85f9d57c296736182a487719a71dd77b9170d6ec
--- /dev/null
+++ b/output/text/1b0979d6-d7a9-405d-a7e9-39dc58cf03ff.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: FMP/SSN: Specimen #: DOb/Age/Sex: Age: F Race: WHITE Location: Taken: Physician(s) : Received: Reported: SPECIMEN: 1cs - 0-3 A: SENTINEL LYMPH NODE #1 B: NON-SENTINEL LYMPH NODE Carcinoma, infiltuti'nrg C: RIGHT BREAST LUMPECTOMY Sit. breast Nos c50.9 FINAL DIAGNOSIS: 125/4 A. LYMPH NODE, SENTINEL, EXCISION: ONE (1) SENTINEL LYMPH NODE POSITIVE FOR METASTATIC CARCINOMA WITH THE LARGEST FOCUS MEASURING 0.4 CM.  TUMOR IDENTIFIED IN THE PERINODAL SOFT TISSUE. B. LYMPH NODE, NON-SENTINEL, EXCISION: - ONE (1) LYMPH NODE COMPLETELY REPLACED BY METASTATIC CARCINOMA MEASURING 1.5 CM. EXTRANODAL EXTENSION CANNOT BE ASSESSED DUE TO LACK OF PERINODAL SoFt tisSue. C. BREAST. RIGHT, LUMPECTOMY:  INFILTRATING DUCTAL CARCINOMA, POORLY DIFFERENTIATED -NOTTINGHAM SCORE: 9/9 (TUBULES=3, NUCLEI=3, MITOSES=3) TUMOR SIZE: 2.7 CM (MEASURED GROSSLY)  TUMOR NECROSIS: ABSENT  MICROCALIFICATIONS: ABSENT VENOUS / LYMPHATIC INVASION: PRESENT  INVASIVE TUMOR INVOLVES THE SMOOTH MUSCLE OF THE NIPPLE  MARGINS: NEGATIVE. DISTANCE OF TUMOR FROM NEAREST MARGIN IS O.6 CM, FROM NEAREST (SUPERIOR) MARGIN. INTRADUCTAL COMPONENT: DUCTAL CARCINOMA IN SITU, SOLID TYPE, NUCLEAR GRADE II, WITH NECROSIS (<5% OF TUMOR). ESTROGEN RECEPTORS, PROGESTERONE RECEPTORS, AND HER 2 NEU PERFORMED ON PREVIOUS SPECIMEN (SEE COMMENT) PATHOLOGIC STAGE: pT2 N1a MX  ADDITIONAL PATHOLOGIC CHANGES: PRIOR BIOPSY SITE CHANGES COMMENT : E. Hormone receptors performed on previous biopsy follows: and are as Estrogen Receptor: Positive (approximately 1oo% nuclear staining) Progesterone Receptor: Positive (25% nuclear staining) - HER-2-NEu: Postive (3+, strongly positive) UUID:7D1C2CD8-9842-48AC-B816-897E2A45388D TCGA-A2-A0CW-01A-PR Redacted Page 1 Continued on Next Page LY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 2 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: FINAL DIAGNOSIS (continued) : ** Report Electronically Signed Out ** CLINICAL DIAGNOSIS AND HISTORY: year old female with right breast invasive cancer PRE-OPERATIVE DIAGNOSIS: Right breast invasive cancer. POST-OPERATIVE DIAGNOSIS: Right breast invasive cancer. GROSS DESCRIPTION: A. Received fresh labeled with patient's name designated "SENTINEL LYMPH NODE" is a 1.5 x 0.5 x 0.3 cm lympn node with attached fibrous fatty tissue. Specimen is bisected and entirely submitted in cassette one. B. Received fresh labeled with patient's name designated "NON-SENTINEL LYMPH NODE" are two irregular portions of presumed previously intact lymph node each measuring 1.5 x 1.5 x 0.1 cm. Sectioning reveals uniform tan and whtie cut surface. Specimen entirely submitted in three cassettes as follows: B1-B2: first portion of node (match of B1 submitted in Ocr for CBcp protocol) B3: remaining portion of lymph node. C. Received fresh labeled with patient's name designated "RIGHT BREAST LUMPEcTOMy" consists of an irregular portion of fibrofatty tissue oriented with single stitch medial and two stitches superior. The specimen measures 10 cm medial to lateral, 7 cm anterior to posterior and 3~cm superior to inferior. Superficial surface displays an 8 x 4 cm lightly pigmented skin ellipse with centrally located fimr inverted nipple. No discharge or scar is identified. Specimen is inked as follows: superior blue, inferior green, medial red, lateral yellow, posterior black. Serial sections reveal well defined 2.7 x 2.7 x 2.2 cm firm pink white gritty mass subadjacent to and involving the nipple. Surrounding breast tissue is fibrofatty and otherwise unremarkable. Cassette key: Page 2 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 Continued on Next Page.
+
+--- Page 3 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient:. Specimen #: GROSS DESCRIPTION (continued) : c1: mass c3: normal skin C4: nipple with mass. c5-cio: representative sections of presumed mass with close proximity to margin c11: medial margin c12: lateral margin. 12cM Page 3. FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 End'of Report
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diff --git a/output/text/1b116a6e-ae22-4e04-b179-19025e935310.txt b/output/text/1b116a6e-ae22-4e04-b179-19025e935310.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e8db3be6410a8240adc6faa7a1158a054520bb1c
--- /dev/null
+++ b/output/text/1b116a6e-ae22-4e04-b179-19025e935310.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1cs-0-3 CacinOmo,ivfi+nrx+'Ng duct,noS 850sf3 c 50.9 Site Cod : bresst, N0s 12|21fo f Final Diagnosis Breast, right, wide local excision: Infiltrating ductal carcinoma, Nottingham grade III (of III), [tubules 3/3, nuclei 3/3, mitoses 3/3; Nottingham score 9/9], forming a 3.5 x 2.5 x 2.5 cm mass [AJCCpT2]. Angiolymphatic invasion is absent. The non-neoplastic breast parenchyma shows nonproliferative fibrocystic changes. All surgical resection margins are negative for tumor (minimum tumor free margin, 0.5 cm medial margin). Lymph nodes, right axillary sentinel, excision: Multiple (6) right axillary sentinel lymph nodes with blue dye are negative for metastatic carcinoma (AJCCpN0(i-) (sn)]. Immunohistochemical cytokeratin stain was performed on the paraffin embedded sentinel lymph node tissue and confirms the H&E impression. Lymph node, right axillary non-sentinel, excision: A single right axillary non-sentinel lymph node identified is negative for tumor. Seen in consultation with Dr. Redacted TCGA-AR-A1AQ-01A-PR
\ No newline at end of file
diff --git a/output/text/1b1b2088-e5f4-4776-aaff-dda873c901c8.txt b/output/text/1b1b2088-e5f4-4776-aaff-dda873c901c8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4e4dba081898b3f0aa65743ba67c84443f2c7ab8
--- /dev/null
+++ b/output/text/1b1b2088-e5f4-4776-aaff-dda873c901c8.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+Surgical Pathology Report Name: Case #: DOB: Collected: Gender: Received: MRN: Reported: Location: Copy To: Physiclan: Pathologic Interpretation: A. Sentinel node # 1 count 1CD-0-3 - Metastatic carcinoma to one lymph node, (0/1) Ccrcinoma, inifilfnathy ductel, NOS - Metastatic deposit: 0.6 cm. 8500/3 Sit: brast Nos C50.9 3/12/ NOTE: Metastatic deposit is only present on permanent slides. B. Sentinel node # 2 count - No carcinoma seen in one lymph node (0/1) - immunohistochemistry for keratin to follow. C. Right breast 1 short superior, 1 long lateral: - Invasiye and in situ moderately differentiated ductal carcinoma, Nottingham grade 2 (3+2+1). 2.5 cm in greatest dimension. - Resection margins are free of tumor (closest margin at 1.0 cm: inferior). - Lymphovascular invasion is not present. - Dcis, intermediate nuclear grade without necrosis, cribriform type, present in 2 of 15 slides examined. - See Tumor Summary. Tumor Summary: Specimen: - Total breast UUID:82771A56-81CA-4414-949F-EF8CAE1C98D4 Procedure: TCGA-EW-A1P5-01A-PR Redacted - Total mastectomy Lymph Node Sampling: - Sentinel lymph node Specimen Integrity: - Single intact specimen Specimen Laterality: - Right) Tumor Size: - Greatest dimension of largest focus of invasion: 2.5 cm. Tumor Focality: - Single focus of invasive carcinoma. Macroscopic and Microscopic Extent of Tumor: - Skin: Invasive carcinoma does not invade into the dermis or epidermis - Skeletal Muscle: No skeletal muscle present Ductal Carcinoma in Situ (DCIS): - DCIS is present:  Extensive intraductal component (ElC) negative. - Size (Extent) of DCIS: - Number of blocks with DCiS: 2 - Number of blocks examined: 15 Architectural Pattern: - Cribriform Nuclear Grade: - Grade II (intermediate). Necrosis: - Not identified. Lobular Carcinoma In Situ: - Not identified. Histologic Type of invasive Carcinoma: - Invasive ductal carcinoma Histologic Grade:
+
+--- Page 2 ---
+SURgICAL PATHOL Report - Glandular (Acinar)/Tubular Differentlation: - Score 3: <10 of tumor area forming glandular/tubular structures. - Nuclear Pleomorphlsm: - Score 2: Cells larger than no9rmal with open vesicular nuclei, visible nucieoli, and moderate variability in both size and shape. - Mitotic Count: - Score 1 - Overall Grade: - Grade 2 Margins: - Margins uninvolved by invasive carcinoma: Distance from closest margin: 10 mm (Inferior).. Lymph-Vascular Invaslon: - Not identified Dermal Lymph-Vascular Invaslon: - Not identified. Lymph Nodes: Numbor of sontinel lymph nodes exam!ned: 2 Total number of Iymph nodes oxamined (sentinei and nonsentinei): 2 Number of lymph nodes with macrometastases (>0.2 cm): 1 Number of lymph nodes with micrometastases (>0.2 mm to 0.2 cm and /or > 200 cells): 0 Number of lymph nodes with Isolatod tumor cells (s.2 rmm and 200 cells): 0 Size of largest Metastatic deposit: 0.6 cm Extranodal Extension: - Not identified. Method of Evaluatlon of Sentinei Lymph Nodes: - Hematoxylin and eosin (H&E), one level - Immunohistochemistry. Ancillary Studies: Estrogen Receptor: Pending Progesterone Receptor: Pending Hor2/neu FISH: - Performed on another specimer. : Results: Not amplified (HER2 gene copy <4.0 or ratio < 1.8) Pathologic Staging: Primary Tumor (Invasive Carcinoma) (pT): pT2 Regional Lymph Nodes (pN) Modifier: (sn) pN1a Distant Metastasis (M): Not applicable Pathologic Staging: pT2, pN1a, MX NOTE: Sone immunoh'stochemical antibodies are analyte specfic reagen's (ASRs) yeidated by our iaboratory (Her ? Paryo, H. pytont, H8core). These ASRs are cinicety utetu ndicators that do with frmalin or molecular fxed, parafin embedded tissue. Detection is by LSAB. The resusts are reed by a pathologist as posthe or negative. As the attending pathologist, I attest that I: () Exemind the relevert preperation(s) for the specimen(s); and (4) Renderecthe diegnosis(es). Procedures/Addenda Date Ordered: Status: Signed Out Addendum Date Complete: Date Reported: Addendum Diagnosis "g' Immunohistochemistry for keratin is negative for carcinoma. Page 2 of 4
+
+--- Page 3 ---
+SURGICAL PatHOL Report "C" The tumor cells are posltive for ER and PR and negative for HER-2 by Immunohistochemistry MD Intraoperative Consultation AFS. Sentinel node # 1 count I fs: Negative for carcinoma BFS. Sentinel node # 2 count : fs: Lymph node; negative for tumor. CFS.  Right breast 1 short superior, 1 long lateral fs Inferior margin; negative for tumor (grossly and microscopically 1.0 cm from margin). Superficial margin-negative for tumor (gross and microscopic microscopically 3 cm from tumor). :, MD Clinical History: Patient is a I female with right breast cancer. Pre Qperative Diagnosis: Right breast cancer, tissue study patient Specimen(s) Received: A: Sentinel node # 1 count fs B: Sentinel node # 2 count : fs C: Right breast 1 short superior, 1 long lateral fs Gross Description: A. Received in formalin and iabeled *sentinel node # 1 count : fs" consists of irregular shaped, adipose tissue fragment, 1.5 x 1.1 x 0.6 cm. Specimen submitted as follows 1 Section for frozen 2&4 The reminders of the specimen in toto B. Received in formalin and labeled "sentinel node # 2 count fs" consists of irregular shaped, adipose tissue fragment, 2.6 x 1.8 x 0.5 cm. Specimen submitted as follows 1 Sections for frozen 2&3 Reminders of specimen in toto c.  Received in formalin and labeled *right breast 1 short superior, 1 long lateral fs" consists of a mastectomy specimen weighing 6.63 grams and measures 20.0 x 16.0 x 4.0 cm. Specimen is oriented with a short stitch superior and a long stitch lateral. There is an ellipse of skin present, 10.0 x 5.5 cm the nipple and areola are present. The areola complex measure 5.0 cm in greatest dimension. The nipple is inverted, dlstracted and measures 0.7 cm in greatest dimension. For. gross purpose the specimen is inked as follow: Superior resection margin inked blue, inferior resection margin inked green, medial resection margin inked red, laterai resection margin inked orange, anterior margin inked yelloy and posterior surgical resection margin inked black. Sectioning of the specimen reveals an ill-defined, pale-tan, fim mass, 2.5 x 1.5 x 1.5 cm. This mass is grossly located 1.0 cm from Inferior resection margin and 3.0 cm from lateral re$ection margin. It is located 2.0 cm from the anterior resection margin and 1.0 cm from the deep resection margin. Ypon sectioning the stroma is composed of yellow, iobulated adipose tissue. The firm, white area is closely associated with the skin. No other lesions are identified. Specimen submitted as follows. Inferior margin for frozen sections 7 Page 3 of 4
+
+--- Page 4 ---
+SURGICAL PATHOL Report 23 Lateral margin for frozen sections Nipple 4-6 Sections of mass 1 Prior biopsy site with clip. 8 Closest deep margin 9 Mass with skin 10 Medial margin 11 Superior margin 12 lower inner quadrant 13 Upper inner quadrant 14 Upper outer quadrant 15 Lower outer quadrant ICD-9(s): 196.3174.8 Page 4 of 4
+
+--- Page 5 ---
+Anatomic Pathology Consult Report Name: Case #: DOB: Collected: Gender: Received: MRN: Reported: Location: Copy To: Physician: Cllent: Interpretation: RIGHT BREAST: INFILTRATING DUCTAL CARCINOMA, INTERMEDIATE NUCLEAR GRADE iMMUNOHISTOCHEMISTRY IS REPORTED TO BE POSITIVE fOR ESTROGEN RECEPTOR AND PROGESTERONE RECEPTOR (IN THE ORiGINAL LABORATORY). HER2-FISH IS REPORTED TO BE NEGATIVE (IN THE ORIGINAL LABORATORY) OTE:S 36-PR .1485-HER2. H-11-EGFR. CCH2/DDG9-CMV, F39.4 1-AR and HPV by 1 ire FD  Qre w=d 1DS-ER, ICs-0-3 MD Cascinomt, in piltratny cluct,nrs 8500f3 ned the releven StH : brust, Nos C50.9 3/13fn h nsend R Clinical History: Right breast core biopsy from a female Specimen(s) Received: SP consult, slides only Slide(s)/Block(s) Received: RECEIVED 1 SLIDE LABELED Collection Date: : Page 1 of 1
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diff --git a/output/text/1b4618b9-5b44-43b3-b2dd-27a3ec908c7d.txt b/output/text/1b4618b9-5b44-43b3-b2dd-27a3ec908c7d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5cc91c0188f3cba3af7e7818905686a8554aa020
--- /dev/null
+++ b/output/text/1b4618b9-5b44-43b3-b2dd-27a3ec908c7d.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+PREVIOUS DIAGNOSIS INQUIRY UUID:104F14E5-32DF-4DEF-BB06-307DC8FEE6A1 TCGA-LS-A40W-01A-PR Redacted PAGE #: SEX: F PROCEDURE:  SPHS sear-old female with prior gastric stapling procedure for obesity and has now developed a distal esophageal Barrett's carcinoma. Operative procedure: Transhiatal esophagectomy. Peripancreatic soft tissue frozen.. Ics-0 -3 hidinocchomn N0s f14013 Sits: esrphagu, chshl thril PROCEDURE: SPGD Cis.s 1. "peripancreatic soft tissue Fs" Received fresh in a small container is a lw 2.0 x 1.1 x 0.3 cm soft tissue. 1A.&3. Frozen section control. 10/9/1 2. "Low paraesophegeal left lymph node Fs Received fresh in a small container is a lymph node, 1.1 cm, bisected. Frozen section control.. 3. "Thoracic esophagus" Received in a small container is a 7.2 cm segment of distal esophagus with an attached 7.0 x 4.0 x 3.5 cm stomach. Attached to the distal portion ot the stomach is a 4.8 cm segment ot bowel, stapled at the margin. The GE junction is remarkable for a 3.1 x 2.3 cm fungating lesion extending 1.6 cm to involve the esophagus, and 2.8 cm to involve the stomach, it is tan-red and centratly ulcerated. The mass extending to within 6.0 cm'of the esophageal margin, and 7.8 cm of the bowei margin. The surface corresponding this area is inked black. Sectioning of the mass reveals ill-defined tan-shite cut surfaces grossly abutting the muscularis, with a maxinuun thickness of t.9 cm. The remaining esophageal uucosa is pink-tan grossly unremarkable with an internal circumference of 4.5 cm and a walt thickness of t.0 cm. The gastric mucosa is tan, with grossty unremarkable rugal folds. At the Junction of the anastomosis between the bowel and the stomach is. a 0.8 x. 0.5 cm full-thickness defect. The bowel mucosa is red-brown, hemorrhagic. Attached adipose tissue has. ten possibte lymph nodes ranging from 0 .2 to 0.8 cm. 3A. Tumor to esophageal mucosa. 3B. Tunor to gastric mucosa. 3C.-E. Remaining tumor. 3F. Anastomosis. 3G. Aforementioned full-thickness detect to bowel margin. 3H. Five whole possible lymph nodes. 3I. Four whote possible lymph nodes. 3J. Largest possible lymph node. 8isected. 4.-#Cervieat-margin" -- Received in- a- smatt- container is t-+.7--em-segment- esophagus with a grossly unremarkable trans surface. It is lined by tan-white grossly unremarkable mucosa. Wall thicknesses averages to 0.8 cm. The end opposite the stapled end is shaved and submitted in one cassette.. FROZEN SECTION REPORT: 1A.&B. One lymph node negative for carcinoma.
+
+--- Page 2 ---
+PREVIOUS DIAGNOSIS INQUIRY PAGE #: SEX: F 2. Metastatic adenocarcinoma. have reviewed and interpreted the frozen section. material at the time it was requested.. Permanent sections confirm frozen section reports.. PROCEDURE: SPMI ESOPHAGEAL, CARDIAC AND GASTROESOPHAGEAL JUNCTION CARCINCMA: Type of carcinoma: Adenocarcinoma, spanning the GE junction.. Depth of irvasion: Muscularis propria.. Number of positive lymph nodes: 2/11. Extranodal metastasis: Unknown. Pattern ot invasion: Infiltrative and expansile.. Esophageal and gastric resection margins involved: No. Deep resection margin involved: No. TNM classification: T2 N1 Mx. PROCEDURE: SPDX 1. Lymph node, peripancreetic, excision: One lymph node negative for. carcinoma. 2...Lywphnode... Latt.- Low paraesophagesl. oxcisions-- Metastatie--aden. one lymph node. 3&4. Esophagus, resection: Invasive adenocarcinoma spanning the Ge junction,. extending into the muscularis propria. Metastatic carcinoma in two of eleven lymph nodes. Margins negative. Please see template for details. the signing staff pathologist, have personally examined
\ No newline at end of file
diff --git a/output/text/1b5079a6-4674-445b-a7e3-bda3d87d674e.txt b/output/text/1b5079a6-4674-445b-a7e3-bda3d87d674e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f7e1010505e90143971d6d607353bcebee37bf6f
--- /dev/null
+++ b/output/text/1b5079a6-4674-445b-a7e3-bda3d87d674e.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TCGA #:  Sample iD # Diagnosis: This is a (mainly still) moderately differentiated adenocarcinoma in the cecum (developed in a tubulovillous adenoma) with histopathological differentiation grade G 2 with necroses, with tumor infiltration of the wall layers of the colon as far as into the tunica muscularis, with substantial chronic granulating and recidivist peritumoral inflammation with an acute inflammatory phase characterized by partially purulent abscess formation, with inflammatory adhesions between the walls of the cecum and the ascending colon, with inflammatory adhesions between the external surface of the tumor and the associated omental fat tissue (in II), with a chronic inflammation in the pelvic wall (in I), as well as with chronic lymphadenitis in the regional lymph nodes with small focal epithelioid cell reactions and with structured and unstructured giant cells in individual regional lymph nodes (in Il). Furthermore, overview sections taken from the resection margins are tumor-free and there is a chronic recurrent appendicitis and chronic granulating and recurrent periappendicitis (in II). Based on the sections under investigation, the tumor spread of the cecal carcinoma corresponds to a tumor stage of p T 2, p N 0, M X, R 0. 112+ /cs-0-3 adenocavcenoma, Nos 814o/3 Sire: clcum C18.0 3/301 UUID: C5348097-4824-490A-B2FF-F257BDC9C633 TCGA-AA-A01V-01A-PR Redacted
\ No newline at end of file
diff --git a/output/text/1b567675-2665-4416-9eb5-64ab48f54ab9.txt b/output/text/1b567675-2665-4416-9eb5-64ab48f54ab9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6ed27212c4f12863eadebc183e17bdf93497ed93
--- /dev/null
+++ b/output/text/1b567675-2665-4416-9eb5-64ab48f54ab9.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:69AC5937-3FFD-40FB-9922-79DB3CED7510 CGA-A7-A0DA-01A-PR Redacted 1c0-0-3 Cnrunomn, nifiHt^aHxg ouct, N0s 85oof3 Site: srisst nos C50.9 hU 10/71/ SPECIMEN Left axillary sentinel node. B. Left breast long stitch anterior short superior CLINICAL NOTES prE-Op DiAgnosis: Left breast cancer HISTORY: year old white female with left breast cancer. pOST-OP DIAGNOsIS: Same as above. FROZEN SECTION DIAGNOSISS A - Lymph node negative for metastatic disease. GROSS DESCRIPTION A. The specimen is received fresh for frozen section labeled "left axillary sentinel node". It consists of a portion of adipose tissue measuring 3.2 x 2.1 x 1 cm. On section there is an apparent fatty lymph node measuring 1.5 x 0.5 x 0.4 cm. Some of the fat is trimmed away. The node is bisected and all submitted in one block for frozen section. B. Received fresh for tissue procurement labeled "left breast" is a diffusely cauterized and fragmented, 7.l cm. (superior to inferior) x 5.7 cm. (medial to lateral) x 4.1 cm. (anterior to posterior) soft, lobulated tan gold-white portion of fibroadipose tissue with two sutures as stated previously. Prior to inking the specimen is incised and tissue is recovered for tissue procurement. The specimen is subsequently inked as follows: Anterior blue, posterior black, medial green and lateral orange. The specimen is sectioned from superior to inferior.  There is a poorly circumscribed, 4.0 cm. (superior to inferior) x 3.7 cm. (medial to lateral) x 2.0 cm. (anterior to posterior) rubbery tan white tumor mass with a few central cylindrical firm tan white structures. The lesion focally extends to within 0.15 cm. of the inked anterior surface and 0.3 cm. of the inked posterior margin. The lesion also focally appears to approach lateral inked margin (see block 3). The GROSS DESCRIPTION remaining cut surface consists predominantly of glistening lobulated golden yellow adipose tissue with a scant amount of interspersed delicate tan white fibrosis tissue. Representative sections are submitted in a sequential manner from superior to inferior in ten blocks as labeled. Rs-10. BLocks summARy: 1 - perpendicular sections entire superior margin cap; 2 through 9 - sequential sections; 10 - representative perpendicular sections inferior margin cap.
+
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+MICROSCOPIC DESCRIPTION A.  This single lymph node is examined in its entirety at multiple levels and is negative for metastatic disease, 0/1. B. This excision is status post prior biopsy.. Surrounding the biopsy site there is a high grade invasive ductal. carcinoma associated with high grade ductal carcinoma in situ. Please see the template below. Invasive Carcinoma: Histologic type: Infiltrating ductal carcinoma Histologic grade: Poorly differentiated Overall grade: Elston SBR grade 3 Architectural score: 3 Nuclear score: 3 Mitotic score: 3 Greatest dimension (pt): The tumor measures 4 cm. in greatest dimension, pT2. Specimen margins: Invasive tumor extends to the anterior margin of resection and to within 1.7 mm. of the lateral margin of MICROSCOPIC DESCRIPTION resection. Vessel invasion: Lymphatic invasion present.. Calcification: Negative. Ductal carcinoma in situ: Histologic pattern: Solid. Cancerization of lobules is noted. Nuclear grade: 3. Central necrosis: Minimal. % Dcis of total tumor (if mixed): 25% Extensive intraductal component (present/absent): Present. Specimen margins: High grade Dcis extends to the anterior margin of resection, to within 0.4 mm. of the lateral margin of resection. There is also a focus of cribriform ductal. carcinoma present to within 0.4 mm. of the inferior margin of resection. Calcification: Negative. Description of non-tumorous breast: A few cysts are noted with ductal hyperplasia. Prognostic markers:  These have been previously performed. 4x2, 14
+
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+DIAGNOSIS A. Left axillary sentinel node, biopsy - Single lymph node negative for metastatic disease, 0/1. B. Left breast, excision - Breast tissue, status post prior biopsy. with residual infiltrating ductal carcinoma, Elston sbR grade III. Lymphatic invasion is noted and extension to margin of resection is present. High grade ductal carcinoma in situ is also present and also extends to margin of resection. DIAGNOSIS (Electronic Signature) - End Of Report
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+Page 1 of 7 UUID:F782DE7F-4DE3-476D-BDF6-549CD871EE9C TCgA-XF-A9T3-01A-PR Redacted DIAGNOSIS: ANTERIOR PELVIC EXENTERATION, STUDER POUCH TO URETHRA, PELVIC LYMPHADENECTOMY ANDS G-TUBE PLACEMENT: 10DO-3 RIGHT DISTAL URETER (AFS): arcinom, drsthelxI NoS FROZEN SECTION DIAGNOSIS: NO HIGH GRADE ATYPIA OR TUMOR IDENTIFIED 812o] 3 FINAL DIAGNOSIS: Sute: MBlssder NoS BENIGN URETER C b7.9 NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED JtJ3|Zb|14 LEFT DISTAL URETER (BFS): FROZEN SECTION DIAGNOSIS: NO HIGH GRADE ATYPIA OR TUMOR IDENTIFIED FINAL" DIAGNOSIS: BENIGN URETER NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED LEFT PARA AORTIC LYMPH NODES (CFS): FROZEN SECTION DIAGNOSIS: BENIGN FINAL DIAGNOSIS:  NO MALIGNANCY IDENTIFIED IN. SEVEN LYMPH NODES EXAMINED (O/7)) APICAL URETHRAL MARGIN (DFS): FROZEN SECTION DIAGNOSIS: NO HIGH GRADE ATYPIA OR TUMOR IDENTIFIED FINAL DIAGNOSIS: BENIGN URETHRAL AND PERIURETHRAL TISSUE NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED BLADDER, UTERUS, BILATERAL OVARIES AND TUBES AND CERVIX (E) : INTRAOPERATIVE GROSS DIAGNOSIS: TUMOR EXTENDING THROUGH WALL WITH CLEAR MARGINS FINAL DIAGNOSIS: BLADDER : INVASIVE POORLY DIFFERENTIATED UROTHELIAL CARCINOMA (3.5 X 3 X 1.8 CM),S GRADES 3 & 4/4, EXTENDING GROSSLY AND MICROSCOPICALLY THROUGH MUSCULARIS PROPRIA INTO PERIVESICAL SOFT TISSUE OF TRIGONE, LEFT LATERAL WALL, AND LEFTS URETEROVESICAL JUNCTION LYMPHOVASCULAR INVASION IDENTIFIED FOCI OF CYSTITIS GLANDULARIS ET CYSTICA AND ASSOCIATED MILD TO MODERATE UROTHELIAL DYSPLASIA NO HIGH GRADE DYSPLASIA OR UROTHELIAL CARCINOMA IN SITU (FLAT LESION) IDENTIFIED RESECTION MARGINS, FREE OF UROTHELIAL DYSPLASIA AND MALIGNANCYS UTERUS : CERVIX, CHRONIC CERVICITIS AND SQUAMOUS METAPLASIA VAGINAL CUFF, MILD CHRONIC INFLAMMATION ENDOMETRIUM, INACTIVE MYOMETRIUM, SEROSA, AND BILATERAL FALLOPIAN TUBES SHOWING NO SIGNIFICANTS LESION BILATERAL OVARIES, BENIGN PHYSIOLOGIC CHANGES NO ATYPIA, DYSPLASIA OR MALIGNANCY IDENTIFIED RIGHT PARA CAVAL LYMPH NODES (F: NO MALIGNANCY IDENTIFIED IN TWO LYMPH NODES BXAMINED (0/2)
+
+--- Page 2 ---
+Page 2 of 7 Ordered LEFT COMMON ILIAC LYMPH NODES (G) : NO MALIGNANCY IDENTIFIED IN SEVEN LYMPH NODES EXAMINED (O/7) RIGHT COMMON ILIAC LYMPH NODES (H):  NO MALIGNANCY IDENTIFIED IN THREE LYMPH NODES EXAMINED (O/3) RIGHT EXTERNAL ILIAC LYMPH NODES (I) :  NO MALIGNANCY IDENTIFIED IN FIVE LYMPH NODES EXAMINED (O/5) RIGHT LYMPH NODE OF CLOQUET (J): NO MALIGNANCY IDENTIFIED IN ONE LYMPH NODES EXAMINED (O/1) RIGHT OBTURATOR/HYPOGASTRIC LYMPH NODE (K) : NO MALIGNANCY IDENTIFIED IN SIX LYMPH NODES EXAMINED (O/6) LEFT EXTERNAL ILIAC LYMPH NODES (L):  METASTATIC CARCINOMA IDENTIFIED IN ONE OF FOUR LYMPH NODES EXAMINED (1/4) LEFT LYMPH NODE OF CLOQUET (M) : BENIGN MATURE FIBROADIPOSE TISSUE NO LYMPHOID TISSUE OR MALIGNANCY IDENTIFIED (O/O) [ENTIRELY SUBMITTED]) LEFT OBTURATOR/HYPOGASTRIC LYMPH NODES (N) :  NO MALIGNANCY IDENTIFIED IN EIGHT LYMPH NODES EXAMINED (0/8) RIGHT PELVIC LYMPH NODES (O): BENIGN MATURE FIBROADIPOSE TISSUE NO LYMPHOID TISSUE OR MALIGNANCY IDENTIFIED (O/O) [ENTIRELY SUBMITTED] RIGHT PRE SCIATIC LYMPH NODES (P) : NO MALIGNANCY IDENTIFIED IN THREE LYMPH NODES EXAMINED (O/3) PRE SACRAL LYMPH NODES (Q: METASTATIC CARCINOMA IDENTIFIED IN ONE OF FOUR LYMPH NODES EXAMINEDS (1/4) REMOVED LEFT URETERAL STENT (R) :  MEDICAL DEVICE CONSISTENT WITH URETERAL STENT (GROSS ONLY) LEFT PRE SCIATIC LYMPH NODES (S) : NO MALIGNANCY IDENTIFIED IN TWO LYMPH NODES EXAMINED (0/2) LEFT PROXIMAL URETER (T) : BENIGN URETER  NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED RIGHT PROXIMAL URETER (U) : BENIGN URETER EXHIBITING URETERITIS GLANDULARIS  NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED LYMPH NODE SUMMARY: METASTATIC CARCINOMA IDENTIFIED IN TOTAL OF TWO OF 52 LYMPH NODES EXAMINED (2/52). LARGEST METASTATICS DEPOSIT 5 MM WITH EXTRANODAL EXTENSION PATHOLOGIC TNM STAGE:S pT3bN2MX
+
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+Page 3 of 7 ly signed by Verified: COMMENT: Representative sections of invasive carcinoma are submitted for p53 assay by immunohistology, results of which will be issued in an addendum.. SPECIMEN SOURCE: AFS: :Rt. distal ureter - f/s" BFS: "Lt. distal ureter -f/s" CFS: "Lt. para aortic LN- f/s" DFS: " Apical urethral margin-f/s" E: "Bladder, uterus, bil. ovaries and tubes and cervix". F: "Rt. para caval LN" G: "Lt. common iliac LN" H: "Rt. common iliac LN' I : "Rt. external iliac LN" J: "Rt. LN of Cloquet" K: "rt. obturator/hypogastric LN" L: "Lt.  external iliac LN" M: "Lt. LN of Cloquet" N: "Lt. obturator/hypogastric LN" "Rt. pelvic LN" 0 P : "Rt. pre sciatic LN Q: "Pre sacral LN" R: "Removed Lt. ureteral stent" S: "Lt. pre sciatic LN" T: "Lt. proximal ureter" U: "Rt. proximal ureter" CLINICAL INFORMATION: Pre-Op Dx:  Bladder cancer Post-Op Dx: Same as pre-op GROSS EXAMINATION: A: The specimen is received fresh from the o.R. and labeled "Rt. distal ureter . f/s". It consists of a segment of gray-pink soft tubular tissue measuring 0.4 cm. in diameter and 0.4 cm in length..  Entirely submitted for frozen section diagnosis. and resubmitted for permanent processing in cassette AFs. B: The specimen is received fresh from the O.R. and labeled "Lt. distal ureter f/s". It consists of a segment of soft gray-pink tubular tissue measuring 0.5 cm in diameter and 0.5 cm in iength. Entirely submitted for frozen diagnosis and. resubmitted for permanent processing in cassette BFs.. C: The specimen is received fresh from the O.R. and labeled "Lt. para aortic LN-. f/s". It consists of a piece of fibrofatty tissue measuring 3.5 x 1.5 x 0.8 cm which contains five lymph nodes measuring up to o.s cm in greatest dimension. Entirely submitted for frozen section diagnosis and resubmitted for permanent processing in cassette cFs.. D: The specimen is received fresh from the O.R. and labeled "Apical urethral margin-f/s". It consists of a piece of soft pink-gray tissue measuring 1.4 x 0.3 x 0.2 cm. Entirely submitted for frozen section diagnosis and resubmitted for. permanent processing in cassette DFs.. E: The specimen is received fresh from the O.R. and labeled "Bladder, uterus, bil..
+
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+Page 4 of 7 ovaries and tubes and cervix". It consists of an anterior pelvic exenteration specimen. Overall, the specimen measures 37 x 16 x 4.5 cm and on the posterior surface has an attached smooth, glistening, mobile, pink-yellow peritoneum. measuring 37 x 16 by less than 0.1 cm.  The peritoneum does not appear to be involved by tumor. The specimen consists of a bladder (5 x 5 x 2.5 cm), attached. globoid uterus (7 x 5 x 1.8 cm), attached bilateral fallopian tubes (right 10 cm in iength and 0.4 cm in diameter, left 11 cm in length and 0.4 'cm in diameter), and attached bilateral ovaries (right 2.2 x 1.3 x 0.8 cm, left 3.4 x 1 x 0.8 cm). The uterus and bladder are attached but freely mobile with regard to one another. The specimen surgical resection margins are entirely inked black.. The bladder is. opened along the anterior wall, revealing a pliable uninvolved wall thickness of 1 cm. The right and left ureterovesical junctions are identified and are probe patent. Both ureters' are opened. The right attached ureter measures 5.5 cm in length and o.6 cm in circumference with normal .appearing mucosa. The left attached ureter measures 4.5 cm in length and 0.7 cm circumference.. Involving the left. ureterovesical junction, left'lateral wall, and left portions of the posterior  wall and trigone is an ulcerated, exophytic, firm, gray-yellow, ill-defined tumor which measures 3.5 x.3 x 1.8 cm. Upon sectioning through the tumor, it extende through the bladder wall and into the perivesical fat but does not involve the inked black resection margin or' the peritoneum. The tumor extends to.a depth of i.8 cm and is. 0.2 cm from the inked margin and the peritoneum. Cut surfaces of the tumor are solid, firm, homogeneous, and white. The remainder of the bladder and ureteral. mucosae are gray and wrinkled. No lymph nodes are grossly palpated in .the. perivesical fat. The specimen is returned to the OR at the surgeon's request for gross consultation, at which time he is informed that tumor extends grossly through the bladder wall with clear resection margins. The bladder and ureteral mucosae are then fixed in Bs fixative for one hour and the specimen is subsequently entirely fixed in formalin for a prolonged period prior to taking sections for permanent processing. The serosa of the uterus is tan-pink, smooth and dull.  The fallopian tubes and ovaries are grossly unremarkable. Upon sectioning through the ovaries. the cut sections are white to yellow, solid, firm, and grossly unremarkable. The ectocervix is 'covered by a shiny, pink-white mucosa. The ectocervix measures 3 x. cm and has a flattened os measuring 1.3 x 0.1 cm.  Surrounding the ectocervix is a. rim of wrinkled, gray-pink vaginal mucosa measuring 0.3 cm wide that appears grossly unremarkable.  The uterus is bivalved revealing an endocervical canal. measuring 2.5 cm in length that is lined by a smooth tan mucosa.  The endometrial cavity measures 2.5 x 1.6 x 0.5 cm and is iined by a thin, soft, tan, uniform endometrium 0.1 cm thick.  The myometrium averages 1 cm in thickness and shows no masses or gross abnormalities. Representative sections are submitted in 20 cassettes. F: The specimen is received in formalin and labeled "Rt. para caval LNn. It consists of multiple fragments of fibrofatty and tan-pink lymphoid tissue measuring 2 x 0.8 x 0.3 cm in aggregate. Entirely submitted in one cassette. G: The specimen is received in formalin and labeled 'Lt. common iliac Ln". It consists of multiple fragments of fibrofatty and tan-pink lymphoid tissue measuring 4 x 2 x 0.5 cm in aggregate. Entirely submitted in four cassettes. H: The specimen is received in formalin and labeled "Rt. common iliac LN'. It consists of fibrofatty and lymphoid tissue measuring 6.2 x 2 x 0.4 cm..  Entirely submitted in three cassettes. I: The specimen is received in formalin and labeled "Rt. external iliac LN. It consists of a piece of fibrofatty and lymphoid tissue measuring 9 x 2.5 x 0.8 cm in aggregate. Entirely submitted in seven cassettes. J: The specimen is received in formalin and labeled "Rt. LN of Cloquet". It consists of a tan-pink lymph node measuring 0.4 x 0.2 x 0.2 cm with attached fat measuring 1 x 0.5 x 0.1 cm. Entirely submitted in one cassette..
+
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+Page 5 of 7 ordere K: The specimen is received in formalin and labeled "Rt. obturator/hypogastric LN" It consists of fragments of fibrofatty and lymphoid tissue measuring 5.5 x 2.5 x 0.5 cm in aggregate. Entirely submitted in four cassettes. L: The specimen is received in formalin and labeled "Lt. external iliac LN". It consists of multiple fragments of fibrofatty and lymphoid tissue measuring 4 x 2 x 0.4 cm in aggregate. Entirely submitted in three cassettes.. M: The specimen is received in formalin and labeled "Lt. IN of Cloquet". It consists of fragments of fibrofatty tissue measuring 0.4 x 0.4 x 0.1 cm in aggregate. Entirely submitted in one cassette.. N: The specimen is received in formalin and labeled "Lt. obturator/hypogastric LN". It consists of multiple fragments of fibrofatty and tan-pink lymphoid tissue measuring 5 x 3 x 0.8 cm in aggregate. Entirely submitted in five cassettes. O: The specimen is received in formalin and labeled "Rt. pelvic LN". It consists of fragments of fibrofatty tissue measuring 2.2 x 2 x 0.4 cm in aggregate. Entirely submitted in one cassette.. P: The specimen is received in formalin and labeled "Rt. pre sciatic LN". It consists of multiple fragments of fibrofatty tissue measuring 2 x 1.5.x 0.3 cm in aggregate.  Entirely submitted in one cassette.. Q: The specimen is received in formalin and labeled "pre sacral LN". It consists of a segment of fibrofatty and lymphoid tissue measuring 4 x 1.5 x 0.5 cm. Entirely submitted in two cassettes. R: The specimen is received fresh in a plastic bag and labeled nRemoved Lt. ureteral stent". It consists of a blue plastic catheter which measures 37 cm in length and 0.2 cm in diameter with a 0.1 cm in diameter lumen. The specimen is perforated with tiny holes arranged in a spiral pattern down the length of the catheter. There is no associated soft tissue. Gross description only. S: The specimen is received in formalin and labeled "Lt. pre sciatic LN". It consists of multiple fragments of fibrofatty and lymphoid tissue measuring 2 x 2 x 0.3 cm in aggregate. Entirely submitted in two cassettes. T: The specimen is received in formalin and labeled "Lt. proximal ureter". It consists of a segment of gray-pink soft tubular tissue measuring 2 cm in length and 0.4 cm in diameter with attached soft fatty tissue. There is a staple located 0.6 cm from one end.  The margin opposite the stapled end is considered the true proximal margin. Serially sectioned and entirely submitted in two cassettes. U: The specimen is received in formalin and labeled "Rt. proximal ureter". It consists of a segment of gray-pink soft tubular tissue measuring 0.8 cm in length and 0.3 cm in diameter.  There are two staples equally spaced along the tubule.. The specimen is serially sectioned and entirely submitted in one cassette. SECTIONS: AFS: frozen section, right distal ureter BFS: frozen section, left distal ureter ces: frozen section, left para-aortic lymph node DFS: frozen section, apical urethral margin E1: bladder, uterus, bilateral ovaries and tubes and cervix; anterior. wall of bladder E2 : dome of bladder E3 : posterior wall of bladder E4 : right lateral wall of bladder
+
+--- Page 6 ---
+Page 6 of 7 Ordere E5-9: left lateral wall of bladder and tumor. ELO: trigone E1l: right ureterovesical junction E12,13: left ureterovesical junction E14: base and neck of bladder with edge (inked blue) where Drs removed E15: anterior vaginal margin and anterior cervix E16: posterior vaginal margin and posterior cervix E17: anterior endomyometrium and serosa E18: posterior endomyometrium and serosa E19: right fallopian tube and ovary E20: left fallopian tube and ovary F: right paracaval lymph nodes; all embedded, with one lymph node inked black and bisected G1: left common iliac lymph nodes; one lymph node, bisected. G2: two lymph nodes, bisected, one inked'black G3 : remaining lymphoid tissue G4 : remaining tissue. H1: right common iliac lymph nodes; one lymph node, serially sectioned H2 : remaining lymphoid tissue H3 : remaining tissue. 11,2: right external iliac lymph nodes; one matted lymph node, serially sectioned 13-6: each cassette contains one lymph node, bisected 17: remaining tissue J: right lymph node of Cloquet - all embedded K1,2: right'obturator/hypogastric lymph nodes; one lymph node, bisected K3 : remaining lymphoid tissue K4 : remaining tissue L1: left external iliac lymph nodes; one lymph node, bisected. L2: remaining lymphoid tissue L3 : remaining tissue M: Ieft lymph node of cloquet - all embedded N1,2: left obturator/hypogastric lymph nodes; one lymph node, bisected N3 : one lymph node, bisected N4 : remaining lymphoid tissue. N5 : remaining tissue 0: right peivic lymph nodes p: right presciatic lymph nodes. Q1: presacral lymph nodes; one lymph node, bisected. Q2 : remaining tissue S1 : left presciatic lymph nodes; one lymph node, bisected S2 : remaining tissue T1: left proximal ureter; proximal margin. T2 : remainder of specimen U: right proximal ureter - all embedded INTRAOPERATIVE FROZEN CONSULTATION: AFs: Right distal ureter:  no high grade atypia or tumor identified BFS: Left distal ureter:  no high grade atypia or tumor identified cFs:  Left para-aortic lymph node: benign
+
+--- Page 7 ---
+Page 7 of 7 DFS: Apical urethral margin:.  no high grade atypia or tumor identified. INTRAOPERATIVE GROSS CONSULTATION Bladder, uterus, bilateral tubes, ovaries and cervix (A):. tumor extending through wall with clear margins. MICROSCOPIC EXAMINATION: A-D: See final microscopic-diagnosis.. E: Sections of the bladder show an invasive poorly differentiated urothelial carcinoma, grades 3 & 4/4, that involves the left lateral wall (E5-9), trigone (E10), left ureteral vesical junction (E12,13) and base of bladder (Ei4). The tumor extends through the muscularis propria and into the perivesical fat but does not involve the peritoneum or the inked margins..  The closest inked resection margin is 0.2 cm from tumor (Es). Lymphovascular invasion is noted (E8,10,13). Multipl'e foci of of mild to moderate urothelial dysplasia are identified in the left lateral wall (E6, 8), trigone (Elo), right uvJ (E1l), and left uvJ (E12, 13). but no urothelial carcinoma in situ (flat lesion).. F-U: See final microscopic-diagnosis.. j i/n/14
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diff --git a/output/text/1bb73f05-90ff-49b8-8a09-e885bb5717dd.txt b/output/text/1bb73f05-90ff-49b8-8a09-e885bb5717dd.txt
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+UUID:97E6278D-5ACD-470C-847D-D882EA709B28 TCGA-HZ-A9T3-06A-PR Redacted ] Referring Physician: DOB: Age: Gender:M Ref#: Hosp#: Provider Group : Date of Service: Date Received: Inpatient Case #: Date Reported: FInAl SUrGICAL PAThOLOgy REPOrt Diagnosis: ICD O3 A. peritoneum, Biopsy: Cleucareeucm NiDS 8140/3 - METASTATIC ADENOCARCINOMA. Sit.: Yanwaotal. c&s.2 B. UmBILICaAl NODULE, rESECTION: hJ s/s/14 - MeTASTaTIC ADeNOCARCINOMA. C. Liver, Left LObe nodule, excisional biopsy: - METASTATIC ADENOCARCINOMA. D. panCREaS, SpLEen And Left ADreNAL GLAnd, RaDiCal AnTegraDE MODULAR PANCREATICOSPLENECTOMY: - INVASIVE PANCREATIC ADENOCARCINOMA, MODERATELY DIFFERENTIATED - Size 8.0 cm with direct invasion into left adrenal gland and fibrovascular bundle of splenic hilum. - Tumor involves wall of stomach (see micro). - Positive for perineural invasion. - Suspicious for lymphovascular invasion. - PANCREATIC MARGIn NEGATIVE FOR MALIGNANCY. - PANCREATIC INTRAEPITHELIAL NEOPLASIA (PanIN-III). - ONE BENIGN LYMPH NODE (0/1). PATHOLOGIC TUMOR STAGING SUMMARY: Histotogic type and grade: Pancreatic adenocarcinoma, Grade 2, moderately differentiated. Primary tumor: pT3. Regional lymph nodes: pNO. Distant metastasis: pM1. Pathologic stage: IV.. Lymphovascular invasion: Suspicious focus. Perineural invasion: Positive. Case #: Page t Printed: : his report continues... (FINAL) MR No :thology - Page 1/6
+
+--- Page 2 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT E. TRAnSVerSe meSOcOLOn NoDuLE, rESEctIOn: - METASTATIC ADENOCARCINOMA. Tumor Staging Information. Data derived from current specimen. Staging in accordance with or modified from AJCC Cancer Staging Handbook, 7th Ed, and CAP protocol, June, 2012. Case1 Page 2 Printed: This report continues... (FINAL). aholoqy - ~age 2/6 age 2 Doc#1
+
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+Patient: Case # FINAL SURGICAL PATHOLOGY REPORT  Signeu uy Source of Specimen: A. Peritoneal bx B. Umbilical bx C. Liver bx D. Pancreaticosplenectomy E. Transverse mesocolon Clinical History/Operative Dx:  Pancreatic cancer Intraoperative Diagnosis: A. Peritoneal biopsy (FSA1): - Adenocarcinoma. B. Umbilical nodule, resection (FsB1): - Adenocarcinoma. Reported by The intraonerative interoretation(s) was/were performed and rendered at. Gross Description: A. Part A is designated as peritoneal biopsy. Initially received in the fresh state for frozen section evaluation is a 1.5 x 1.0 x 0.9 cm red-tan nodular piece of soft tissue. The specimen is bisected and one half is submitted for frozen section evaluation. The residual frozen tissue is submitted in A1 for permanent sections and the remaining half is submitted in A2 for routine histology.. 3. Part B is designated as umbilical biopsy. Initially received in the fresh state for frozen section evaluation is a lobular and tattered portion of fatty soft tissue measuring 2.5 x 1.5 x 1.0 cm. Sectioning reveals a red-tan nodule, 1.7 x 1.0 x 1.0 cm. One half of the nodule is submitted for frozen section evaluatlon. The residual frozen tissue is submitted in B1 for permanent sections and the remaining half of the nodule including attached fat is submitted in B2 for routine histology.. C. Part C is designated as liver biopsy. Received in formalin is an irregular fragment of deep tan-brown soft tissue consistent with liver parenchyma, measuring 0.9 x 0.6 x 0.5 cm. The specimen is bisected Case #: Page 4 Printed: This report continues... (FINAL) MR No thology - Page 4/6 - Page 4 Doc#1
+
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+Patient: Case #: FINAL SURGICAL PATHOLOgy REPORT revealing a circumscribed, glistening, light gray nodule, 0.4 x 0.3 cm. The specimen is submitted in its entirety between two sponges bisected in C1.. D. Part D is pancreaticosplenectomy. Initially received in a fresh state for harvesting tissue for is a pancreaticosplenectomy consisting of spleen, distal pancreas, adrenal gland,. and two attached pieces of stomach. The dimensions of the pancreas is difficult to discern due to replacement by tumor that invades the surrounding soft tissue; however, is up to 10.0 cm in length and 4.3 x 1.9 cm. Sectioning through the stapled proximal margin of resection reveals tan pancreatic parenchyma without gross tumor involvement. Upon sectioning transversely, reveals a wel-demarcated tumor mass, grossly 1.8 cm from the pancreatic surgical margin and measuring upwards of 8.0 x 4.3 x 3.5 cm. The tumor mass is dense, light gray and demonstrates obvious involvement into the peripancreatic soft tissue within 0.2 cm of the anterior and posterior radial surfaces. The apparent adrenal gland is slightly distorted, measures upwards of 4.0 x 1.8 x 1.5 cm, and is partially encased and involved by tumor grossly (D11-D12). The remaining length of the pancreas is grossly involved with tumor with the likely distal end of the tail demonstrating poorly visualized lobular, yeilow-tan fat and possible pancreatic parenchyma (D9-D10, contiguous sections). A smaller plece of attached stomach is 4.3 x 1.3 x 0.6 cm, deep red-tan and is incised to reveal prominently wrinkled, deep tan mucosa without gross tumor involvement (D13): A larger wedge-like piece of stomach is 5.9 x 2.0 cm and is red-tan with submucosal tumor involvement (D16). The grossly involved area is greater than 1.0 cm away from the stapled surgical margin. The tumor grossly invades the hilar fat up to.the spleen and encasing the splenic vessels. The spleen is 8.7 x 7.6 x 3.3 cm with a glistening, deep purple-tan intact capsule. The spleen is serially sectioned revealing deep red parenchyma without discrete nodularity or grossly invasive tumor component. Lymph nodes searched within the hilar region and superior peripancreatic fat is hindered by tumor replacement. Representative sections are submitted for microscopic evaluation. Cassette summary: D1-D2) proximal pancreatic margin of resection, contiguous sections,. D3) proximal end of pancreas and adjacent tumor relationship,. D4-D10) representation of tumor replaced pancreas, submitted in a sequential fashion proximal towards distal end, D11-D12) adrenal gland - tumor, D13) small wedge of stomachl, surgical margin, submitted,. D14-D15) larger wedge of stomach, surgical margin trimmed and submitted,. D16) stomach wedge with tumor involvement,. D17-D18) spleen with hilum and tumor. E. Part E is transverse mesocolon biopsy. Received in formalin is a 4 gram piece of lobular and slightly tattered fatty soft tissue, 3.3 x 2.0 x 1.4 cm. A double suture denotes an area of palpable, poorly visualized nodularity. This surface is now marked orange and the remaining margins biack. Examination reveals deep yellow-tan, dense nodularity measuring up to 1.1 x 1.0 x 0.7 cm surrounded by glistening. yellow fat. The nodularity is within O.3 cm of the likely surgical margin (black). The lesion is entirely submitted for. Case #: Page 5 Printed: This report continues... (FINAL.). athology - Page 5/6. 5 Doc# 1
+
+--- Page 5 ---
+Patient: Case #: FINAL SurGiCAL pAThOLOgy REpOrt microscopic evaluation in E1 and E2 with additional representation of the fat in E: Microscopic Description: A. Sections of the peritoneal biopsy show peritoneum with attached skeletal muscle partially involved by metastatic adenocarcinoma forming irregular glands with surrounding desmoplastic stroma. No Iymphovascular invasion is identified. B. Sections of the umbilical nodule show adenocarcinoma involving fibroadipose tissue. The tumor is at the cauterized edge of the fragment. No lymphovascular invasion is identified. C. Sections of the liver biopsy show a subcapsular focus of metastatic adenocarcinoma. A portion of  benign liver tissue is present. No lymphovascular invasion is identified. D. Sections of the pancreaticosplenectomy show an invasive adenocarcinoma involving the tail of the pancreas. The tumor forms irregular small glands with a surrounding desmoplastic stroma. There is a minor cord and single cell patten. The nuclei are enlarged with prominent nucleoli and there is cytoplasmic mucin. Perineural invasion is present and there is a focus suspicious for lymphovascular invasion. There are some dilated pancreatic ducts with severe dysplasia and carcinoma in situ. The invasive tumor invades into the surrounding peripancreatic soft tissue with involvement of the left adrena! gland and tibrovascular bundle of the splenic hilum without direct invasion into the splenic parenchyma. The larger wedge of attached stomach has tumor invading through the wall up to the mucosa. It cannot be determined if this focus is due to direct extension or metastatic spread. A single benign peripancreatic lymph node is present. The pancreatic margin is uninvolved. E. Sections show mesenteric tissue with foci of adenocarcinoma composed of irregular small glands surrounded by desmoplastic stroma. No lymphovascular invasion is identified. Case # Printed: MR No. r\cct No - -rtient Name - 1hology - Page 6/6 DISQUAL
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diff --git a/output/text/1bbea23d-7de5-4a8d-9a0a-140c8268cbfe.txt b/output/text/1bbea23d-7de5-4a8d-9a0a-140c8268cbfe.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6563813a4e80afa998611ed5f386d02a422a6e7c
--- /dev/null
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+
+--- Page 1 ---
+Icd-0 - 3 Caranoma, hfilt^atwg duct,NOS 8500|3 128/10 Poth lw Srte lodi: bruust, contral Puntton c 50.1 CQcF Sin: busst,N03 c5o.q UUID: 0B6DCA80-3108-4D25-B095-3EC704598823 TSS TCGA-E2-A14R-01A-PR Redacted SPECIMENS: A. SENTINEL NODE #1 LEFT AXILLA B. SENTINEL NODE #2 LEFT AXILLA C. SENTINEL NODE #3 LEFT AXILLA D. WIDE LOCAL EXCISION LEFT BREAST NEEDLE LOCALIZATION E. INFERIOR MARGIN LEFT BREAST F. LATERAL MARGIN LEFT BREAST G. MEDIAL MARGIN LEFT BREAST H. POSTERIOR MARGIN LEFT BREAST I. SENTINEL NODE #4 LEFT AXILLA J. SENTINEL NODE #5 LEFT AXILLA K. SENTINEL NODE #6 LEFT AXILLA SPECIMEN(S): A. SENTINEL NODE #1 LEFT AXILLA B. SENTINEL NODE #2 LEFT AXILLA C. SENTINEL NODE #3 LEFT AXILLA D. WIDE LOCAL EXCISION LEFT BREAST NEEDLE LOCALIZATION E. INFERIOR MARGIN LEFT BREAST F. LATERAL MARGIN LEFT BREAST G. MEDIAL MARGIN LEFT BREAST H. POSTERIOR MARGIN LEFT BREAST i. SENTINEL NODE #4 LEFT AXILLA J. SENTINEL NODE #5 LEFT AXILLA K. SENTINEL NODE #6 LEFT AXILLA INTRAOPERATIVE CONSULTATION DIAGNOSIS:E TPA-TPC: One lymph node each part, negative for carcinoma D: Gross assessment 2.0 cm mass >0.5 cm all margins and 1.0 cm satellite nodule at inferior margin. TPI: One lymph node, negative for carcinoma TPJ/FSJ: 2 lymph nodes, negative for carcinoma TPK: One lymph node, nenative for carcinoma By Dr. called to Dr. at 1 (A), (B), C), : (D) and (I, J, K). GROSS DESCRIPTION: A. SENTINEL NODE #1, LEFT AXILLA Received fresh and labeled with the patient name designated "A -- sentinel node #1, left axilla", is a fragment of  beige-tan possible lymphoid tissue measuring 2.0 x 2.0 x 1.2 cm. The specimen is serially sectioned, touch prep performed. The entire specimen is submitted in cassette A1 and A2.. B. SENTINEL NODE #2, LEFT AXILLA  Received fresh and labeled with the patient name designated "8 -- sentinel node #2, left axilla", is a fragment of  beige-tan possible lymphoid tissue measuring 1.0 x 1.0 x 1.3 cm. The specimen is serially sectioned, touch prep performed. The entire specimen is submitted in cassette B1 and B2.. C. SENTINEL NODE #3, LEFT AXILLA Received fresh and labeled with the patient name designated "C -- sentinel node #3", is a fragment of beige-tan possible lymphoid tissue measuring 0.7 x 0.5 x 0.3 cm. The specimen is serially sectioned, touch prep performed.. The entire specimen is submitted in cassette C1.. D. LEFT BREAST WIDE NEEDLE LOCALIZATION  Received in fresh state the specimen labeled with patients name and identification number and labeled as wide local. excision left breast needle localization. The specimen consists of 293 grams resected breast tissue measuring 12.5 cm from medial to lateral, 7.5 cm from anterior to posterior and 6.0 cm from superior to inferior. The margins of specimen are oriented with sutures, single indicating anterior, double-lateral and triple-superior. There is a Iocalization needle coursing from the superior to the inferior aspect of the specimen and the accompanying. radiogram that shows density located in the mid portion of the specimen. The margins of specimen are color coded  as follows: Inferior-orange, superior-red, lateral-yellow, anterior-blue, medial-green and posterior-black. At mid. portion of the specimen is a firm palpable mass which on cut section shows solid firm mass with nodular and Iobulated pushing borders with a tan white cut surface with total dimensions of 4.0 x 3.0 x 0.9 cm. A metallic clip is identified within the main portion of the tumor and the surrounding breast tissue consists mostly of fatty parenchyma.. The tumor grossly 0.9 cm from the nearest inferior margin. Multiple sections are submitted and labeled as follows: D1-D8: One en bloc section of tumor with margins.
+
+--- Page 2 ---
+D9: Cross section of tumor D10-D18: En bioc section of tumor with margins, (block 15 section taken site of apparent previous biopsy site wherein a clip was identified) D19: Sections of gross fat necrosis D20: Sections from posterior and medial margins D21: Sections from inferior and medial margins D22-D23: Sections from the posterior margin. D24-D25: Sections from lateral margin n26-D27: Additional medial margin E. LEFT BREAST INFERIOR MARGIN Stitch marks new margin. Received fresh is an oriented 17.0-gram fragment of fibrofatty tissue 6.0 x 5.0 x 2.0 cm. The new true margin is inked blue, the specimen is serially sectioned and submitted in toto in cassette E1-E11. F. LEFT BREAST LATERAL MARGIN Stitch at new lateral margin. Received fresh is an oriented tan-pink fragment of fibrofatty tissue 5.0 x 2.0 x 1.5 cm. The new true margin is inked blue. Also separate within the container is an unoriented tan-pink fragment of fibrofatty tissue 5.5 x 4.0 x 2.0 cm. The specimen is inked blue. The entire specimen is submitted as follows:. F1-F5: Oriented tissue fragment F6-F12: Unoriented tissue fragment. G. LEFT BREAST MEDIAL MARGIN Irregular fragment of fibrofatty tissue measuring 3.5 x 2.0 x 1.0 cm. Submitted in toto in cassettes labeled G1-G2. H. LEFT BREAST POSTERIOR MARGIN  Received fresh is an unoriented 3.0-gram tan-pink fragment of fibrofatty tissue 4.0 x 2.0 x 1.5 cm. The specimen is inked blue, serially sectioned and submitted in toto in cassette H1 and H2. I. SENTINEL NODE #4, LEFT AXILLA Received fresh is a tan-pink lymph node 0.8 x 0.7 x 0.7 cm. The specimen is serially sectioned, touch preps are taken. The specimen is submitted entirely in cassette I1. J. SENTINEL NODE #5, LEFT AXILLA  Received fresh are 2 tan-pink lymph nodes 1.5 x 1.0 x 1.0 cm and 0.8 x 0.5 x 0.5 cm. A portion of the larger lymph  node is submitted for frozen section in FSJ1. Touch preps are taken. The remainder of the lymph node is submitted as follows: J2-J3: One lymph node J4: One lymph node K. SENTINEL NODE #6, LEFT AXILLA Received fresh is a tan-pink lymph node 0.7 x 0.6 x 0.5 cm. The specimen is bisected. Touch preps are taken and the specimen is submitted entirely in cassette K1.. DIAGNOSIS: A. SENTINEL LYMPH NODE #1, LEFT AXILLA - ONE LYMPH NODE, NEGATIVE FOR TUMOR (O/1) B. SENTINEL LYMPH NODE #2, LEFT AXILLA  - ONE LYMPH NODE, NEGATIVE FOR TUMOR (O/1). C. SENTInEL LyMPH NODE #3, LEFT AXILLA - ONE LYMPH NODE, NEGATIVE FOR TUMOR (0/1). D. LEFT BREAST, NEEDLE LOCALIZATION WIDE LOCAL EXCISION - INVASIVE QUCTAL CARCINOMA WITH AREAS OF NECROSIS, SBR GRADE III OF LEFT BREAST. - SIZE OF TUMOR: 4.0 x 3.0 x 0.9 CM.  - PREDOMINANTLY FATTY BREAST TISSUE WITH FOCAL AREAS OF COLUMNAR CELL CHANGE. - POST BIOPSY SITE CHANGES. - MARGINS OF RESECTION-NEGATIVE FOR TUMOR. E. LEFT BREAST, INFERIOR MARGIN: - PREDOMINANTLY FATTY BREAST TISSUE-NEGATIVE FOR TUMOR. F. LEFT BREAST, LATERAL MARGIN: - FATTY SREAST TISSUE-NEGATIVE FOR TUMOR. G. LEFT BREAST, MEDIAL MARGIN:
+
+--- Page 3 ---
+- FATTY TISSUE AND 1 MM FOCUS OF LYMPH NODE-NEGATIVE FOR TUMOR (0/1).E H. LEFT BREAST, POSTERIOR MARGIN: - FATTY BREAST TISSUE INCLUDING SKELETAL MUSCLE TISSUE-NEGATIVE FOR TUMOR.E I. SENTINEL LYMPH NODE #4, LEFT AXILLA:I - ONE LYMPH NODE, NEGATIVE FOR TUMOR (0/1). J. SENTINEL LYMPH NODE, #5 LEFT AXILLA: . TWO LYMPH NODES, NEGATIVE FOR TUMOR (0/2) K. SENTINEL LYMPH NODE #6, LEFT AXILLA: - ONE LYMPH NODE, NEGATIVE FOR TUMOR (0/1). Note: specimen # D- grossly, of what appears clinically as two tumor is only one large tumor with lobulated and nodulat extensions.the main bulk of the specimen consist mostly of fatty breast tissue. SYNOPTIC REPORT - BREASTE Specimens Involved Specimens:  D: WIDE LOCAL EXCISION LEFT BREAST NEEDLE LOCALIZATION Specimen Type: Excision Needle Localization: Yes Laterality: Left Invasive Tumor: Present Multifocality: No WHO CLASSIFICATION Invasive ductal carcinoma, NOs 8500/3 Tumor size: 4cm Additional dimensions: 3cm x 0.9cm Tumor Site: Central Margins:  Negative Distance from closest margin: 1.5cm superior Tubular Score: 3 Nuclear Grade: 3 Mitotic Score: 3 Modified Scarff Bloom Richardson Grade: 3 Necrosis: Present Vascular/Lymphatic Invasion: Indeterminate Lobular neoplasia: None Lymph nodes: Sentinel lymph node only Lymph node status: Negative 0/8 Non-neoplastic areas: Post biopsy site changes DCIS not present Pathological staging (pTN): pT 2 N O SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimens Involved Specimens: D: WIDE LOCAL EXCISION LEFT BREAST NEEDLE LOCALIZATION Specimen: Surgical Excision Block Number: D9 ER: Negative Allred Score: 0 = Proportion Score 0 + Intensity Score 0 PR: Negative Allred Score: 0 = Proportion Score 0 + Intensity Score 0 COMMENT: The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring range from 0 to 8. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than. or equal to 2. METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours..  Immunohistochemistry was performed using the mouse anti-human ER (ER 1D5, 1:100) and PR (PGR 136, 1:100)
+
+--- Page 4 ---
+provided by Dako .) following the manufacturer s instructions. This assay was not modified. Interpretation of the ER/PR immunonistochemical stain is guided by published results in the medicai literature. information provided by the reagent manufacturer and by internal review of staining performance. CLINICAL HISTORY: -year-old Caucasian female with palpable left breast mass. Ultrasound showed 2 masses at 12 o'clock position, Iargest one 2.0 cm. Core biopsy showed DCis, here for wide local excision and sentinel node biopsy. PRE-OPERATIVE DIAGNOSIS:  None given ADDENDUM: SYNOPTIC REPORT - BREAST HER-2 RESULTS Specimen:  Surgical Excision Block Number: D9 Interpretation: NEGATIVE Intensity: 1+ % Tumor Staining: 8% Fish Ordered: No METHODOLOGY:  Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Her2 analysis was performed using the FDA approved Dako HercepTest (TM) test kit (Dako, Carpenteria, CA) using rabbit anti- human HER2. This assay was not modified. External kit-slides provided by the manufacturer (cell lines with high, low and negative HER2 protein expression) and in-house known HER2 amplified control tissue were evaluated along with the test tissue. Adequate, well preserved, clear-cut invasive carcinoma was identified for HER2 evaluation. Interpretation of the HER2 immunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal review of staining performance.. This assay has been validated according to the 2007 joint recommendations and guidelines from AScO and CAP  and from the NCCN HER2 testing in Breast Cancer Task Force. The Pathology Department takes full responsibility for this test's performance. Gross Dictation: Pathologist, Microscopic/Diagnostic Dictation: Pathologist. Microscopic/Diagnostic Dictation: Pathologist. Final Review: Patholoaist. Final: Pathologist, Addendum: Pathologist, Addendum Final: Pathologist
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diff --git a/output/text/1bc3b6c4-6ce9-4b6f-ae85-2cd8adad616f.txt b/output/text/1bc3b6c4-6ce9-4b6f-ae85-2cd8adad616f.txt
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index 0000000000000000000000000000000000000000..3a06c29bb2f668d0ae735dbd74c04f8b019b16ae
--- /dev/null
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+--- Page 1 ---
+page 1 / 1 Department of Cancer Pathology copy No. Date: Examination: Histopathological examination Internal invoice No. Cost of diagnostic procedure Examination No.: Patient: XXX PEsEL: XXX Age: Gender: F 1cS-0-3 Material:Multiple organ resection - right breast with'axillary tissues Caici,ona, mnfiltmstny duct,Nrs 85o0f Unit in charge: Sih: beot, Nos C5o.9 pw 4f13fr  Physician in charge: Material collected on: Material received on: Expected time of examination: up to 8 working days Clinical diagnosis: Cancer of the right breast. Specimen from a modified radical mastectomy using technique. Examination performed on: Macroscopic description: Right breast siz@d 20 x 16 x 5 cm removed along with axillary tissues sized 9 x 11 x 3 cm and a skin flap of 20 x 8 cm. Weight 880 g Tumour sized 2.2 x 2.0 x 1.5 cm on the border of the outer quadrants, located 3.0 cm from the lower boundary, 1.2 cm from the base and 1.6 cm from the skin. Lymph nodes of 1.0 cm in length. Microscopic description: Carcinoma ductale invasivum, basal-like NHG3 (3 + 3 + 2/15 mitoses/10 HPF - visual area 0.55 mm).  Reactio lymphocytaria peritumoralis. Mamilla sine laesionibus. UUID:3386269D-1D59-4184-A786-28E873F6D3A8 Axillary lymph nodes: TCGA-D8-A1XQ-01A-PR Redacted Lymphonodulitis reactiva No VII.. Histopathological diagnosis: Invasive ductal carcinoma of the right breas?(NHG3, pT2, pNO). Compliance validated by: Examination performed on: Results of immunohistochemical examination: No estrogen receptors found in neoplastic cell nuclei. Progesterone receptors found in less than 10% of neoplastic cell nuclei. HER2 protein stained with HercepTesttM by DAO. Negative reaction in invasive cancerous cells ( Score = 1+ ). Tests performed twice. Compliance val CONTACT YOUR DOCTOR WITH THIS RERODT!
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diff --git a/output/text/1bde829b-1ecc-4dfc-b676-e934ba170640.txt b/output/text/1bde829b-1ecc-4dfc-b676-e934ba170640.txt
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index 0000000000000000000000000000000000000000..5ae61d007dd67e3baa6e3ff969d2f66763068b23
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:04B1F253-2351-4BA6-A289-A22BC1E19C35 TCGA-YZ-A983-01A-PR Page 1 of 5 Redacted Facility  Name Resuit Information Status Provider Status Final result Reviewed Reviewed by List MD on Observation Date and Time Specimen Type Tissue Procurement Entry Date Result Narrative Surgical Pathology Report Patient Name: Accession #:1 Med. Rec #: Submitting Physician: Clinical History Neovascular glaucoma of right eye [365.63]. Intraocular tumor [239.89]. Total retinal detachment of right eye [36l.05]. Medical history: -year-old with large choroidal malignant tumor. Blind painful eye with Nvg. Gross photos. Evaluate malignant tumor. Differential diagnosis includes metastasis and uveal melanoma. ---Final Pathologic Diagnosis-- A. Right eye, resection: Choroidal melanoma (amelanotic), see synoptic report Iris neovascularization with partial angle closure Retinal detachment IaD o3 - Cataract Malantmo, ypithelirolesQ0 SYNOPTIC REPORT FOR UVEAL MELANOMA Procedure: 87713 Enucleation: Specimen Size: C69.3 For Enucleation: Anteroposterior diameter: 25 mm Horizontal diameter: 23 mm )3/12/14 Vertical diameter: 24 mm Length of optic nerve: 11 mm Diameter of optic nerve: 3 mm Specimen Laterality: Right Tumor Site: Other (specify): Posterior adjacent to optic disc Page 1 of 5
+
+--- Page 2 ---
+rage  or  Tumor Size: LBD: 16 mm (gross); 13 mm (from slide) Height: 10 mm (gross); 11 mm (from slide). Tumor Involvement of Ocular Structures: Choroid posterior Retina Tumor Location After Sectioning (microscopic) Distance from anterior edge of tumor to limbus at cut edge: 1l mm Distance of posterior margin of tumor base from edge of optic disc: 0 mm Growth Pattern: Solid Histopathologic Type: Epithelioid cell melanoma (greater than 90t epithelioid cells) Histologic Grade (pG): pG3 Microscopic Tumor Extension Tumor Location Anterior margin between disc and equator Posterior margin between disc and equator Scleral Involvement: None Margins No melanoma at margins Extrascleral extension (for enucleation specimens) - negative Pathologic Staging (pTNM) pT3a NX MX Additional Pathologic Findings (select all that apply) Mitotic rate (number of mitoses per 40x objective with a field area of 0.152 mm2): 1/40 high power fields Microvascular patterns: poorly formed vascular mimicry patterns present Vascular invasion (tumor vessels or other vessels): negative Degree of pigmentation: none Inflammatory cells/tumor infiltrating lymphocytes: present/mild Drusen: none Retinal detachment: present Invasion of Bruch' s membrane: yes. Nevus: negative Hemorrhage: negative Neovascularization: yes Other: fibrous plaque overlying tumor Comment(s): pAs stain was used to evaluate for possible vascular mimicry patterns. Cytokeratin AEl/3 is negative (ruling out carcinoma/metastasis): and HmB-45 and melanA are strongly positive, consistent with melanoma. All controls show appropriate reactivity.. Immunohistochemical (Ihc) testing for HER2 is performed accordinq to manufacturer' s instructions at ! In-situ hybridization tests were developed by and are performed at the All other Ihc and histochemical tests were developed by and are performed at the  Al tests reported here, except those addressing HEr2 overexpression as a predictive marker, are not required to have nor do they have FDA approval. ***Electronically Signed By*** M.D. Page 2 of 5
+
+--- Page 3 ---
+Page s or  -SpEcImen(S) REceIveD:-- Neuropath, Eye, enucleation/evisceration. --GROSS DESCRIPTION:--. The specimen is received in one properly labeled container with the patient' s name and accession number.. A. The specimen is designated "right eye" and consists of a 9.0 gram intact globe which is 25.0 mm from anterior to posterior, 23.0 mm horizontally, 24.0 mm vertically, with corneal measurements of 11 vertically and 12 horizontally. The optic nerve is 1l.0 mm in length. Upon opening, the lens is intact and present. The tumor as measured by Dr. is 16.0 mm in width (largest basal diameter?) and 10.0 mm high. TE3 Summary of Cassettes: Al-3, entire globe (trisected, middle slab with optic nerve and mass = A2) Lab Use Only: Job ID Gross description by: Patient Release Status: This result is not viewable by the patient.. Reviewed by List Patient Care Team Relationship Specialty Notifications Start End Ophthalmology MD Medical Oncology All results, DO Admissions Procedures with Linked Chargeables Chargeable CpT Code 88305 88305 Facility Name SURG PATH REQUEST (Order #
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diff --git a/output/text/1c08ab3d-8c2d-4903-a7f0-0af126c1c79c.txt b/output/text/1c08ab3d-8c2d-4903-a7f0-0af126c1c79c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..aebc2bf3365907be30e07634aa048fa7f7b8da28
--- /dev/null
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+
+--- Page 1 ---
+UUID:0E633883-3C48-4D53-B7BF-EtE0BDF73DED TCGA-YC-A89H-01A-PR Redacted EDo-3 'acerors,wrsthusal NoS Research Gross Description 8/203 year-old female, bladder cancer, not previously treated. Sute Bhaddar NOs C b79 Research Dx Invasive high grade urothelial carcinoma.. CASE SUMMARY FOR URINARY BLADDER BIOPSY AND TRANSURETHRAL RESECTION OF BLADDER TUMOR (TURBT): 50% squmour ,pw T3S. Histologic type: Urothelial carcinoma with squamous differentiation. Ace Associated epithelial lesions: None identified Histologic grade (WHO/ISUP): High grade. Tumor configuration: Indeterminate Adequacy of material for determining muscularis propria invasion: Muscularis propria identified Lymphovascular invasion: Not identified Microscopic extent of tumor: Tumor invades muscularis propria.. Additional pathologic findings: None identified AJCC Staging (7th edition): pT2 pNX pM:Not applicable Research QC Tumor 1: 50% tumor nuclei 0% necrosis 50% normal this is very cauterized 75% tumor nuclei 5% necrosis 20% normal 50% squamous differentiation T3 there are 2 pieces, one is 50% tumor/50% normal; the other is entirely nonneoplastic  % tumor nuclei _% necrosis % normal T4 30% tumor nuclei 0% necrosis 70% normal Normal: na Research Specimen. Specimen Process Time Blood draw time:
+
+--- Page 2 ---
+Plasma frozen time Serum frozen time: Buffy coat frozen time: Tissue: Cold ischemia start time: Formalin fixation start time:. Frozen start time Total cold ischemia time Formalin fixation stop time:. Total formalin fixation time:. Specimen Weight Tumor x 4 - 1. 480 mg 2. 430 mg 3. 440 mg 4. 490 mg Specimen Size Plasma x 3 Serum x 2 Buffy coat x 1 Cryovials x 4 Normal x 0 Tumor x 4 - 1. 480 mg 2. 430 mg 3. 440 mg 4. 490 mg Metastatic x 0 FFPE x 4 Normal x 0 Tumor x 4 Metastatic x 0 Studv Patient Consent Yes 2
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diff --git a/output/text/1c2bf79c-22fe-49cd-99a1-8f03f9ab42fa.txt b/output/text/1c2bf79c-22fe-49cd-99a1-8f03f9ab42fa.txt
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index 0000000000000000000000000000000000000000..12d777629946dbe3368d8d76b4d2496ae80cb368
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+
+--- Page 1 ---
+Surgical Pathology Report Name: DOB: Case #: Collected: Gender: F Recelved: MRN: Reported: Locatlon: Copy To: Physician: Pathologic Interpretation: A. Right axilla: - Micrometastatic carcinoma in one out of six lymph nodes (1/6). - Size of metastatic deposit: 1.25mm - Note: Immunohistochemistry for keratin was used for interpretation.. B. "'Right lumpectomy: - Invasive. poorly differentiated ductal carcinoma, high nuclear grade, 1.5 cm in greatest dimension. - Invasive carcinoma is present at less than 1 mm from the inferior margin.. - Ductal carcinoma in situ is present within 1 mm of lateral and inferior margins.. - Lymphovascular space invasion is identified. - Previous biopsy site.. - See Tumor Summary. 1es-0-3 Carciionn inflfnatiwy dut;[Nrs 8500/3 Tumor Summary: Sit: brust, Nos C50.9 3/12/n M Specimen Type: Right lumpectomy Procedure: Excision with wire-guided localization Lymph Node Sampling: Sentinel iymph nodes UUID: 88E39E13-8ADC-481A-992E-610838E8C8D4 Specimen Integrity: Single intact specimen TCGA-EW-A1OV-01A-PR Redacted Specimen Size: - Greatest dimension: 8.9 cm. - Additional dimensions: 8.2 x 2.3 cm. Laterality: Right Tumor Size: - Greatest dimension of largest focus of invasion over 0.1 cm: 2.5 cm. - Additional dimensions: 2.2 x 1.2 cm.. Tumor Focality: Single focus of invasive carcinoma Macroscopic and Microscopic Extent of Tumor: Skin: Invasive carcinoma does not invade into the dermis or epidermis.. Skeletal Muscle: No skeletal muscle present. Histologic Type: Invasive ductal carcinoma. Histologic Grade: - Glandular (Acinar)/Tubular Differentiation: Score 3: <10% of tumor area forming glandular/tubular structures - Nuclear Pleomorphism: Score 3: Vesicular nuclei, often with prominent nucleoli, exhibiting marked variation n size and  shape, occasionally with very large and bizarre forms. Mitotic count: Score 1 Overall Grade: Grade 2: Score of 6 or 7 Margins: Margins uninvolved by invasive carcinoma. Distance from closest margin: < 1 mm (inferior) Specify margins: Distance from superior margin: 10 mm Distance from inferior margin: < 1 mm Distance from anterior margin :> 10 mm. Distance from posterior margin: < 2 mm Distance from medial margin :> 10 mm Distance from lateral margin: > 10 mm Margins: uninvoived by DCIS: Distance from closest margin: < 1 mm (inferior, lateral) Treatment Effect: Response to Presurgical (neoadjuvant): Therapy: No known Presurgical therapy. Lymph-Vascular Invasion: Present Dermal Lymph-Vascular Invasion: Not identified. Lymph Nodes:
+
+--- Page 2 ---
+SURGICAL PATHOL Report Number of sentinel nodes examined: 6 Total number of nodes examined (sentinel and Nonsentinel): 6. Number of lymph nodes with macrometastases (>0.2 cm): 0. Number of lymph nodes with micrometastases (>0.2 mm to 0.2 cm and/or>200 cells): 1 Number of lymph nodes with isolated tumor cells (<0.2 mm and s200 cells): 0 Size of largest metastatic deposit: 1.25mm Extranodal Extension: Not identified.. Method of evaluation of Sentinel Lymph Nodes: - Hematoxylin and eosin (H&E). one level. - Immunohistochemistry Pathologic Staging (pTNM): pT2, pN1ml, pM (not applicable) Reglona! Lymph Nodes (pN): pN1mi Ancillary Studies: To Follow. ts ore rea by a NOTE: Some in pothoiogist as pnsitive or negnuive. As the attending pathologist, I attest that I: (i) Examined the relevant preparatton(s). for the specimen(s): and (it) Rendered the diagnosis(es).. MD : ***Electronically Signed Out By**** Procedures/Addenda Date Ordered: Status: Signed Out Addendum Date Complete: Date Reported: Addendum Diagnosis A. Right axilla: - The tumor cells are negative for ER, PR and Her-2 by Immunohistochemistry. - The tumor cells are also negative for E-cadherin. - This immunophenotype may be seen in the basal subtype of mammary carcinoma.. - Additional Immunohistochemistry to follow.. , MD Date Ordered: Status: Signed Out Addendum Date Complete: Date Reported: . Addendum Qiagnosis 8. Right lumpectomy one suture superior, two medial:. Page 2 of 3
+
+--- Page 3 ---
+SURGICAL PATHOL Report - The tumor cells are positive for p-cadherin and negative for CK5/6 and EGFR by Immunohistochemistry.. MD Intraoperative Consultations Right axilla, FS: 3 lymph nodes: no tumor on frozen section. Await sentinel node protocol for definitive diagnosis. MD Clinical History: Patient with biopsy proven G3 cancer right breast 1 for needle localization segmental mastectomy with SLN3. Please evaluate sentinal nodes for metastasis and do Immunohistochemistry on permanents if frozen negative, evaluate lumpectomy.  margins. Operation Performed Right needle localization mastectomy with SLNB, possible AND, right lumpectomy. Pre Qperative Dlagnosis:. Cancer right breast Specimen(s) Recelved: A: Right axilla fs B: Right lumpectomy one suture superior , two medial Gross Description: A.  Received fresh for frozen section is an irregular fragment of fibroadipose tissue, measuring 3.2 x 2.0 x 1.1 cnj. Seven lymph nodes are identified at the time of consultation. In the rest of the adipose tissue two possible lymph nodles are identified. The fragments are submitted in toto as follows: 1-3 One lymph node per cassette for frozen section 4&5 One additional lymph node per cassette 6&7 The rest of the fibroadipose tissue B. Received in formalin is a lumpectomy specimen, measuring 8.9 cm from medial to lateral, 8.2 cm from anterigr to posterior, 2.3 cm in from superior to inferior. A metallic localization needle is located in the anterior aspect of the specimen. Surgical margins are inked as follows: superior inked blue, inferior inked green, medial inked red, fateral inked. orange, anterior inked yellow, posterior inked black. Upon sectioning at the tip of the needle localization an irnregular firm, tan and white area is identified, measuring, 2.5 x 2.2 x 1.2 cm. This area is up to, 0.1 cm from the inferior margin, 1.5 cm  from the deep posterior margin, 4.5 cm from the anterior margin, 2.3 cm from the lateral margin, 1.0 cm from the superior margin, 3.2 cm from the media! margin. Representative section of the tumor is submitted for tissue bank. Other areas of the specimen are fibroadipose with a stroma to fat ratio of 10:90. Representative sections are submitted as fojlows: 1&2 Sections of the tumor in relation with the inferior and superior margins. 3 Tumor in relation with the deep margin 4&5 Additional sections (composite) of the tumor in relation with the inferior and deep margins. 6 Lateral margin 7  Medial margin 8 Anterior margin 9-11 Additional sections of the tumor.
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diff --git a/output/text/1c432582-55ea-41b7-86c1-c1792a001f48.txt b/output/text/1c432582-55ea-41b7-86c1-c1792a001f48.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3da262305d263aa4cc0aa497f7f2428138fa0f10
--- /dev/null
+++ b/output/text/1c432582-55ea-41b7-86c1-c1792a001f48.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+TSS ID TSS ID:: 5C iC Date of Procurement: Gross Description:e  Breast with the tumor of 3 x 5 cm in size; fatty tissue lymph nodes are dense, hyperemic, up to 1 cm in their diameter. Microscopic Description: Infiltrating duct carcinoma; G. Ten lymph nodes were examined, five lymph nodes demonstrated metastases. Diagnosis Details: Tumor Features: Unknown, Tumor Extent: T2 tumor size more than 2cm not more than 5 cm, Venous Invasion: Absent, Margins: Absent, Treatment Effect: Comments: Formatted Path Report: 1cs-0- 3 BREAST TISSUE CHECKLIST sarcinomu, mfittratng clust, Nos 85o0/3 Sis: kuast, N0s C50.9 lw yf8/1 Specimen type: Radical mastectomye Specimen size: Not specified. Tumor site: Breast Tumor size: 5 x 0 x 3 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinoma Histologic grade: Moderately differentiated Tumor extent: Not specified Lymph nodes: 5/10 positive for metastasis (Axillary 5/10) Extracapsular invasion of the lymph nodes: Not specified Margins: Not specified UUID:50F3690C-2082-4590-A923-656C5F226FAE  Nottingham Histologic Score TCGA-E9-A1RF-01A-PR Redacted Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined
+
+--- Page 2 ---
+TSS ID: Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified. Comments: None Laterality: Left, upper outer quadrante
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diff --git a/output/text/1c4438c0-df90-4f2d-bd9c-cb4ba028118e.txt b/output/text/1c4438c0-df90-4f2d-bd9c-cb4ba028118e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a597f9674b4d8b994eb5b9a06b0f8417cda30303
--- /dev/null
+++ b/output/text/1c4438c0-df90-4f2d-bd9c-cb4ba028118e.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID: 36814259-5757-4205-A247-89D7529AD2CB TCGA-KV-A6GE-01A-PR Redacted Surgical Pathology Report DATE OBTAINED: DATE RECEIVED: DATE REPORTED: CC DIAGNOSIS RIgHT RENAl MASS, PARTIAL NEPHRECTOMy: PAPILLARY RENAL CELl CARCINOMA (TYPE 1). Histologic type: Papillary renal cell carcinoma, type 1 zCD-o3 Fuhrman nuclear grade: II of IV Sarcomatoid features: Not identified Tumor Necrosis: Not identified 8Q0/3 Tumor size: 2.1 cm Tumor site: Right kidney Tumor focality: Unifocal Cb4.9 Macroscopic extent of tumor: Confined to kidney Microscopic extent of tumor: In|3  No transcapsular invasion. Lymphatic/vascular invasion: Absent Margins: Negative, SEE COMMENT. Other Tumors/cysts: Absent Non-neoplastic kidney:  Renal cortical parenchyma with arterial thickening and focal chronic interstitial. inflammation Adrenal gland: Not submitted Lymph nodes: No nodes submitted cTNM (given by clinician): Stage I pTNM: pT1a AJCC Stage: Stage I **Electronically Signed Out*** COMMENT Histologic sections of the right renal mass show a renal cortical neoplasm forming papillae with underlying fibrovascular cores filled with foamy macrophages. No necrosis or high-grade nuclei are identified.  Immunohistochemical studies show the tumor cells to be positive for CK 7, AMACR, and CD 10 supporting the diagnosis of papillary renal cell carcinoma. The tumor is present at the parenchymal margin in an area described by the surgeon as disrupted intraoperatively, and not representing the final true margin (inked orange). The rest of this parenchymal margin is negative for tumor (inked blue).. 88307, 88342 x 3 Clinical Diagnosis and History: Right renal ca Trt Ciinical stage ! Tissue(s) Submitted: RIGHT RENAL MASS Page 1 of 2
+
+--- Page 2 ---
+Surgical Pathology Report Gross Description: The specimen is received fresh for intraoperative consultation and labeled as right renal mass and consists of an ovoid, grey- brown, shaggy specimen measuring 4.0 x 2.5 x 2.0 cm. One half of the specimen is covered in fibrous and adipose tissue while the other half consists of tan-brown, duil, renal tissue as identified by the surgeon. Also, as per surgeon, there is a 0.4 cm defect at the parenchymal margin, this is inked orange. The rest of the parenchymal margin is inked blue. The capsular margin is inked black. Note is made of another defect of the capsular margin measuring 0.3 cm in diameter, this inked green. Serial sections of this entire specimen reveal a 2.1 x 1.7 cm fleshy, yellow-brown, solid mass with hemorrhagic center. There is a 1.0 mm rim of normal renal tissue grossly identified. Also submitted with the right renal mass are fragments of yellow-tan, fibrofatty tissues with an aggregate measurement of 5.0 x 4.0 x 1.0 cm. The entire specimen is submitted as follows:. 1A-1D: serial sections of the entire mass 1E-1F: mass in relation to the capsule perpendicularly sectioned. 1G-1L:  entire fibrofatty tissue that was submitted with the renal mass.. Intraoperative Consult Diagnosis TUMOR GROSSLY AT POINT WHERE TUMOR SPLIT (IDENTIFIED BY SURGEON NOT FINAL MARGIN). S.Z2013  Page 2 of 2 END OF REPORT
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diff --git a/output/text/1c6bfc14-3a69-4871-9e0c-9f5b7ad93d9d.txt b/output/text/1c6bfc14-3a69-4871-9e0c-9f5b7ad93d9d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..96ff99f8f3b0f865cbe67fd4b018c15be751df9a
--- /dev/null
+++ b/output/text/1c6bfc14-3a69-4871-9e0c-9f5b7ad93d9d.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID: 9C41C5B6-1CDA-4857-B9EC-FE888545783F TCGA-V4-A9EY-01A-PR TD o-3 Reda Msonomainypurelle cell NiOS CELE 87723 Sute Chwwsl Cb93 Enucleation of the right eye.. x iyolerIC Cb9 4 MS o/6|14 Macroscopy:e The eyeball measures 30 mm in diameter and the posterior optic nerve segment 11 mm. At the section, it presents a blackish tumor measuring 10 mm main line. Microscopye The histological examination reveals a cell proliferation with the histological features. of a melanoma. This tumor is composed of fusiform cells with ovoid nucleus. harboring frequently nucleolus. Presence of sparse mitotic features (two mitoses per. 10 high power field). No necrosis or microcalcifications. The tumor invades focally the inner part of the sclera, without extrascleral extension. The anterior chamber and the optic nerve on its entire course are free of tumor.. Conclusion: Uveal melanoma composed of fusiform cells.. Tumor size: 10 mm. Tumor infiltration of the inner part of the sclera without extrascleral extension.. Optic nerve in its entire course free of tumor.
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diff --git a/output/text/1caff27a-b27d-4975-97cc-4db2a636bade.txt b/output/text/1caff27a-b27d-4975-97cc-4db2a636bade.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c2776c58419e4020263f0d832f6473f9fac5cbbe
--- /dev/null
+++ b/output/text/1caff27a-b27d-4975-97cc-4db2a636bade.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:11F45993-E238-4B93-9ACF-9B35F2A3FF1E TCGA-D6-A74Q-01A-pR Redacted Patient: xxx  Age Gender: M Examination result No. zCD O a3 Unit in charge: arcinono>, opuemoer  ceSl  Physician in charge: 807113 Clinical diagnosis (suspicion) Cancer of the larynx . Date of admissior 9 9/2w/i3 Material: 1) Material: larynx, Method of collection: Collection of specimens for laboratory examination Histopathological diagnosis:.  Examination performed or Invasive keratinizing squamous cell carcinoma (G3) of the larynx.. Excision lines at the side of the root of the tongue and trachea are free of cancerous lesions.. Margin of the excision at the front right side is below 0.1 cm.. pT4a. (8071/3 T-24100)* codes according to ICD-O-3 or SNOMED Macroscopic description:. Surgical specimen sized: 9 x 5 x 4 cm, including the larynx with the hyoid bone and part of the trachea 2.5 cm in length. In the region of glottis, at the right and left side there is a tumour sized: 2.5 x 2.5 x 1.5 cm invading the subglottal region, supraglottal region, thyroid cartilage and pre-epiglottic space.. Assistant: Pathologist: Edited by Results of intraoperative examination:.  Examination performed on. Margins at the side of the root of the tongue (1 wire) and trachea (2 wires) are free of cancerous lesions.. Assistant: Pathologist. Edited by CONTACT YOUR DOCTOR WITH THIS REPORT!
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diff --git a/output/text/1cb23cc8-b25f-4a0a-9fe9-6c9e555d98d9.txt b/output/text/1cb23cc8-b25f-4a0a-9fe9-6c9e555d98d9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..297bfccb822be21fcb22e589e31b2e216afecf5d
--- /dev/null
+++ b/output/text/1cb23cc8-b25f-4a0a-9fe9-6c9e555d98d9.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID: 85BA09A1-D62B-497F-AEB8-44E9BD279A8B CGA-UZ-A9PZ-01A-PR Redacted SURGICAL PATHOLOGY REPORT * wIth ADDenDum * Patient Name: Accession #: Med. Rec.#: Visit #: Service Date: : DOB: Sex: Received: Soc. Sec. #: Location: Client: Physician(s): Final Pathologic Diagnosis Right kidney, partia! nephrectomy: Papillary renal cell carcinoma, through renal capsule, not present at margins; see comment. ICDO 3 J 8Q60|3 Comment: Kidney Tumor Synoptic Comment SiteOKudney NoS C64.9 - Grade: Fuhrman grading for RCC: II.. - Tumor size: 2.2 cm. - Site within kidney: Unknown. - Renal pelvis: Not applicable. - Ureter: Not applicable. - Renal sinus: Not applicable. - Hitar renal veins: Not applicable. - Intrarenal veins and Iymphatics: Normal.. - Adrenal gland: Not present. - Capsule/perirenal fat: Tumor penetrates capsule with microscopic growth in perirenal fat. - Lymph node status: None present.. - Resection margins: - Ureter: Not applicable.. - Renal vein: Not applicable. - Soft tissue: Negative (tumor is 0.2 cm from margin). - Renal parenchyma: Negative (tumor is 0.02 cm from margin).. - AJcc/UIcC Stage: pT3aNX. Section(s) of renal parenchyma not involved by neoplasm will be reviewed by. with results reported by addendum. Specimen(s) Received.
+
+--- Page 2 ---
+A:Right renal mass (FS) Intraoperative Diagnosis IOC1 (A) Right kidney, partial nephrectomy: 2.2 cm spherical renal neoplasm, confined within capsule, 0.1 cm from parenchymal margin. Clinical History OR Room and Phone # (frozen specimen : intraoperative consults only): Relevant History The patient is a  who, according to .. has a 2.5 cm right renal mass found during workup for gross hematuria. The patient now undergoes partial nephrectomy. Gross Description The case is received fresh labeled with the patient's name, medical record number, and additionally Iabeled "right renal mass (fresh)" and consists of a portion of kidney (25.3 gm; size of whole specimen 7 x 4.5 x 3.5 cm; size of kidney 3 x 2.5 x 2.2 cm). GROsS ABNORMALITIES: One, well-circumscribed, homogeneous, encapsulated, tan-yellow, firm lesion (2.2 x 2 x 1.8 cm) is identified, confined to the kidney parenchyma, 0.1 cm from the parenchymal. margin and 0.2 cm from the perinephric soft tissue margin. The remaining kidney parenchyma is tan-pink and firm. The perinephric adipose tissue is deep yellow and glistening. No lymph nodes are identified. ORIENTED BY: Unoriented INTRAOPERATIVE FINDINGS: Intraoperative consult #1 INKING: -Parenchymal margin-black -Perinephric soft tissue margin-blue pOTENTIAL STUDIES: Snap frozen CAsserres: Representative sections are submitted cassettes as follows: A1-A2: Lesion at closest approach to parenchymal margin. A3-A4: Lesion at closest approach to perinephric soft tissue margin. A5: Uninvolved kidney. Diagnosis based on gross and microscopic examinations. Final diagnosis made by attending pathologist following review of atl pathology slides. The attending pathologist has reviewed all dictations, including prosector work, and preliminary interpretations performed by any resident involved in the case and performed all necessary edits before signing the final report. Electronically signed out on Addendum Date Ordered: Status: Date Complete: By: Date Reported: Addendum Diagnosis Addendum Comment The section of uninvolved kidney (slide A5) was reviewed by and shows no specific pathologic abnormality. Electronica! hw i4py PAAD
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diff --git a/output/text/1cdfff5a-81f3-4043-a002-0d6835a8a2a4.txt b/output/text/1cdfff5a-81f3-4043-a002-0d6835a8a2a4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b9ac502df8e542c233add01312d96f8e93940e51
--- /dev/null
+++ b/output/text/1cdfff5a-81f3-4043-a002-0d6835a8a2a4.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:B140F5B4-5B03-40EC-A5BB-BCF0963EC567 CGA-OR-A5L4-01A-PR Redacted Procedure: adrenalectomy and resection of tumor in vena cava, choecystectomy Gross description: 15 x 9 x 7cm primary tumor, 13.5 x 5.5 x 5cm tumor in vena cava Diagnosis: adrenocortical carcinoma, Kl67 10%, pT2 pNx L0 V1 Pn0 R0 Reference Pathology:. Diagnosis: adrenocortical carcinoma, Kl67 10-20% IcD0-3 Weiss score: 7 arcinono,adreual esrtiea! Hough score: 3.29 8 3x3 Van Slooten score: 13.7 Site Ad^enol CkrsL,Cortex C 744 O JsO Q/6/13
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diff --git a/output/text/1d3d0f12-db6d-4329-98dd-d4d8bdf277bd.txt b/output/text/1d3d0f12-db6d-4329-98dd-d4d8bdf277bd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..46aabf1c9bf69e6f8bbe90b4a7a15b30610de053
--- /dev/null
+++ b/output/text/1d3d0f12-db6d-4329-98dd-d4d8bdf277bd.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+I Diagnosis & History: vith right renal mass. Specimens Submitted: 1: Kidney, right, satelita tumar, excisiun 2: Kidney, right, partial nephrectomy 3: Kidney, right,  deep margin#1, excislon. 4: Kideny, right, deep margin #2; excision. DIAGNOSIS: 1. Kidney, right, "satelite tumor",excision: Benign intra-renal (ectopic) adrenat tlssue 2. Kldnay, right, partial nephrectomy:. Tumor Type: Renal cell carcinama - Conventional (clear cell) type Fuhrman Nuclear Grade: Nuclear grade II/IV Tumor Size: Greatest dlameter is 3.0 om. Local Invasion (for renal curtical types): Nat Identified Renal Vein Invasion:. Not identified  Tumor invades muscular branchas of the renal vain in the ranal hitum. Surgical Margins: Tumor present at renal paranchymal margin (for parllal nephrectomy specimens only). (Nat in the frozen section and the frozen section control. For final margins see paris 3 and 4.) Nun-Neoplastic Kidney: Mild arteriasclerotic changes; a small madullary fibroma Adrenal Gland:. Not identified Lymph Nodes: Nat identified Staging far renal cell carcinoma/oncocytoma:. pT3b Tumor grassly extends into the ranal vein(s) ar vena cava below tha diaphragm. Page 1 of 3
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT 3.  Kidney, right, deep margin #1, excision:. Benign kidney parenchyma. 4.Kideny, right, deep margin #2; excision. Benign fibroadipose and urothalial tissua. Special Studies: Result Special Stein Comment RECUT RECUT Gross Description: 1. The specimen is received fresh, labeled "satellite tumor right kidney' and consists of a single piece of brown soft tissue measuring 0.5 x 0.4 x 0.1 cm. The is antirely submitted.. Summary of sections:. U- undesignated 2). The specimen is received fresh, labalad "right renal tumor, stitch marks deep margin".  It consists of a 5.0 x 3.5 x 2.5 cm wedge shaped porion of kidney with a suture marking the deep margin. Tha margin is inked black and the specimen Is serially sectioned to reveal one wall circumscribad bright-yellow mass, measuring 3.0 x 2.5 x 2.0 cm. The clearanca from the resection margin is less than 0.1 cm.. A representative section of the nearest margin is submitted for frozen section diagnosis. Raprasantatively submitted. Summary of sections:. FSC - frozen section control T - tumor RS - representative sactlons 3. The specimen is recaived frosh, labaled "deep margin # 1, right ranal tumor' and consists of a piece of brown soft tissue  measuring 1.2 x 0.4 x 0.2 cm. The antira specimen submitted. Summary of sections:. U - undesignated 4. Tha spacimen is received fresh, labeled *deep margin # 2, right ranal tumor' and consists of a piece of brown soft tissue  maasuring 1. x 0.3 x 0.2 cm. The antire specimen submitted.. Summary of sections:. U - undesignated Summary of Sections: Part 1:  Kidney, right, satellte tumor, excision. Page 2 of 3
+
+--- Page 3 ---
+SURGICAL PATHOLOGY REPORT Block Sect. Site pCs 1 1 u Part 2: Kidney, right, partial nephrectomy Block Sect. Site PCs 1 fso 1 2 rs 2 6 t 7 Part 3: Kidney, right, deep margin #1, excision Block Seot. Site. pCs 1 u 1 Part 4: Kideny, right, deep margin #2; excision Block Sect. Site. pCs 1 u 1 Intraoperative Consultation: Note:  The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 2) FROZEN SECTION DIAGNOSIS:  RENAL CORTICAL NEOPLASM. MARGIN FREE ON FROZEN SECTION (A THIN CAPSULE PRESENT AT MARGIN. PERMANENT DIAGNOSIS: SEE FINAL Page 3 of 3 END OF REPORT
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diff --git a/output/text/1d7355dc-6d09-4fad-8b8d-737f7a8c5d87.txt b/output/text/1d7355dc-6d09-4fad-8b8d-737f7a8c5d87.txt
new file mode 100644
index 0000000000000000000000000000000000000000..80b4bf6c8c2801126311238a56c9f6e98be420c5
--- /dev/null
+++ b/output/text/1d7355dc-6d09-4fad-8b8d-737f7a8c5d87.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:1E62D739-C4E6-4A3D-AB24-FA4DE1E2F992 TCGA-H6-A45N-01A-PR Redacted ic D O-3 adenxarci nmq,NOS 8(4)|3 Final Surgical Pathology Report. Sik: c4<f: pan<r<as,+ai 1 Procedure: ca5.2 Diagnosis Distal pancreas and spleen, excision - Path: pancseas,No5 Poorly differentiated pancreatic adenocarcinoma, extending into c qs.9 Carcinoma extends at least near to outer resection margin, but not definitively identified at outer margin. q71z  Proximal margin negative for high-grade dysplasia and carcinoma (see microscopic description). RD Spleen without specific diagnostic abnormalities. Metastatic adenocarcinoma in one of twelve (l/12) lymph nodes. Microscopic Description: The following template summarizes the findings in this case: Histologic type: Adenocarcinoma. The specimen also has dilated ducts lined by mucinous epithelium, including in the grossly separate cyst submitted in blocks A3 & A4, compatible with (branch duct-type) Histologic grade: Poorly differentiated Primary tumor: pT3. Carcinoma extends into peripancreatic soft tissues. Margins of resection: Carcinoma extends at least near to the inked outer margin, but is not definitively identified at this margin. There without high grade dysplasia or carcinoma identified at the proximal margin. Regional lymph nodes: pNl. There is metastatic adenocarcinoma in one of twelve (1/12) lymph nodes, with the positive lymph node in block #14. Distant metastasis: Not applicable Vascular invasion: Not definitively identified Other findings: There is perineural invasion by carcinoma, including in areas that grossly appeared normal (block #5). The spleen is without specific diagnostic abnormalities. Note: It is uncertain if the poorly differentiated adenocarcinoma has arisen from the IpmN, or if the Ipmn is an incidental finding in the background. This case has been reviewed in Intradepartmental Consultation, with essential concurrence with the interpretation, with most reviewers favoring the Ipmn is incidental. Specimen Distal pancreas, spleen. Clinical Information PRE-Op DIAGnOsIs: Pancreatic cancer
+
+--- Page 2 ---
+Gross Description Received fresh in a container labeled "distal pancreas, spleen" is a 9 x 5.5 x 3.5 cm portion of distal pancreas, which attached 110 g, 10 x 7.8 x 3.5 cm, spleen. The surface of the spleen is gray-tan and. with diffuse white stippling, without gross abnormality.. There are a. few areas on the hilar surface of the spleen, approximately 2 cm in  The pancreas has a. greatest dimension, where the capsule is absent.. stapled margin proximally. The staples are removed and this surface is. inked black. The remainder of the surface of the pancreas is inked blue. A firm mass can be palpated from the outer aspect of the specimen. The specimen is sectioned, and there is a white-tan ill. circumscribed mass 4.5 x 3.7 x 2.7 cm.  The mass is 3 cm from the proximal resection margin, and 3.5 cm from the spleen..  The pancreatic duct can be traced on cut surface to the tumor, but cannot be probed. The pancreatic duct appears to be markedly stenotic and possibly Obliterated through the area of the tumor.. The pancreatic duct lining. is inked green for identification purposes.  There is some residual. normal appearing tan pancreatic tissue grossly identified outside of the mass. There is an apparent cystic structure near, but not clearly at, the proximal margin of the specimen, 0.7 cm in greatest dimension. This cyst is 0.2 cm from the pancreatic duct. There are a few tan lymph nodes identified in the surrounding adipose tissue. Rs-15, following fixation.. BLOck sumMARy: 1 - vascular margin; 2 - spleen; 3,4 - entire pancreatic cyst, with block 3 including adjacent pancreatic duct margin; 5 grossly normal pancreatic tissue; 6-l1 - tumor, including relation to the pancreatic duct and outer margin; 12-14 - lymph nodes; 15 - additional tissue from proximal pancreatic margin.
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diff --git a/output/text/1d78487d-e7e2-4abe-a0b4-f9484aa481f4.txt b/output/text/1d78487d-e7e2-4abe-a0b4-f9484aa481f4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..35d751c076efa598bd1e4ba8bba547f1c71477e8
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+irfiitrshnj itucf <uvinnu, ors Sit: brat, Nos 1122110 C50.9 page 1 / 2 Department of Cancer Pathology copy No. Date: Examination: Histopathological examination Examination No.: Patien PESEL: Age: Gender: F Material:  Multiole organ resection - left breast Unit in charge. Physician in charge: Material collected on: Material received on: Expected time of exanwnation: up to 8 working days. Clinical diagnosis: Cancer of the left breast.  Examination performed on:  Results of immunohistochemical examination:. Estrogen receptors in neoplastic cell nuclei not found. Progesterone receptors in neoplastic cell nuclei not found. HER2 protein stained with HercepTest'" by DAKO. Score = 2+, verification by the FISH method recommended. Compliance validated by:  Examination performed on: Macroscopic description: / Left breast, sized 20 x 19 x 7 cm, removed along with axillary tissues sized 12 x 14 x 4 cm and a skin flap of 22 x 13 cm. Weight 1,527 g. Tumour sized 6 x 4.5 x 2.5 cm in the outer lower quadrant, placed 4 cm from the lower edge, 2.5 cm from the base and 1.3 cm from the skin. Lymph nodes of 2.3 cm in length. Mitroscopic description: Carcinoma ductale invasivum - NHG3 (3 + 2 +3: 28 mitoses/10 HPF, visual area diameter 0.55 mm). Mamilla sine laesionibus. Glandular tissue showing lesions of the type mastopathia fibrosa. AXILLARY LYMPH NODES Lymphonodulitis chronica et sinus histiocytosis et lipomatosis lymphonodorum (No xiv). Examination result: Carcinoma ductale invasivum mammae sinistrae.. (NHG3, pT3, pN0). Compliance validated by:  Examination performed on: UUID:7D2C880F-6897-44A0-9470-5A5B5429A9C0 TCGA-D8-A142-01A-PR Redacted
+
+--- Page 2 ---
+Examination: Histopathological examination page 2 / 2 Examination No.:  Patient: PESEL: Examination performed on: Gender: F Results of immunohistochemical examination:  RESULT OF HER2/neu GENE AMPL/FICA7iON with the FISH method by Path Vysion HER2 DNA Probe Kit FINAL RESULT: HER-2 Gene AMPLIFICATION NOT FOUND Chromosome 17 polisomy. Compliance validated by:
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diff --git a/output/text/1d7d50f2-9b0e-4444-86e3-30718c33cf53.txt b/output/text/1d7d50f2-9b0e-4444-86e3-30718c33cf53.txt
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index 0000000000000000000000000000000000000000..2c6ae25e2bad09cd99a8a4395d4623067149b51d
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+IcD 03 denscoenmANo S UUID:72D3550D-D524-4965-8C7A-F10060DEA06A TCGA-L5-A8NI-01A-PR 8/40/3 Redacted Cxorhaguo,clsstol 015.5 thurd Sastrlucshagialjuiektn C16.0 yJ 1117/19 Accession: OPER DATE: REQ DOC: PROCEDURE : VERIFIED BY: Source of specimen: Thoracic esophagus.. 'ear-old male with one-year history of dysphagia, treated with positive for cancer. No radiation or chemotherapy. Clinical Diagnosis:. Esophageal cancer. Operative Procedure: Transhiatal esophagectomy..
+
+--- Page 2 ---
+PREVIOUS DIAGNOSIS INQUIRY PAGE #: 3 REPORT DATE: PATIENT NSR: SEX: M NAME : ADM DATE: BIRTHDATE: OPER DATE: REQ DOC: ACCESSION: PRocEdure: VERIFIED BY: 1. "Thoracic esophagus." Received in formalin in a medium container is a 9 x. 4.5 cm distal portion of esophagus, in continuity with 7 x 6 cm portion of. stomach. There is a 6.5 x 5 x 1.1 cm tan-brown, ulcerative tumor with rolled edge at the GE junction. The tumor involves circumferentially 80x of the organ, 6 cm from the esophageal surgical margin and 3.2 cm from the distal gastric surgical margin. The tumor invades through the muscular layer and. approaches the serosal surface. The proximal half of the esophagus and stomach are grossly unremarkable. The serosal surface is inked black, serially sectioned and sampled.. 1A. Tumor at esophageal edge. 18-1c. Tumor. 1D. Tumor at gastric edge. 1E. Normal esophagus and stomach. 1F-1G. Largest lymph node, 2.2 x 1.7 x 1.3 cm. 1H. One lymph node, bisected. Two lymph nodes, inked yel low or orange, bisected.. 1J. Two lymph nodes, inked yellow or orange, bisected.. 1K. Possible lymph nodes. 1L. Possible lymph nodes. 2. "Esophageal margin." A ring of esophagus, 1.2 cm in diameter, 0.7 cm in. length. Margin inked. 3. "Lower teft paraesophageal lymph node." Received in formalin in a small container is a 2.7 x 1.9 x 0.6 cm portion of adipose tissue. Serially sectioned. 3A. Lymph nodes.e 3B. Remaining adipose tissue. PROCEDURE: VERIFIED BY: ESOPHAGEAL, CARDIAC AND GASTROESOPHAGEAL JUNCTION CARCINOMA:S Type of carcinoma: Adenocarcinoma: If adenocarcinoma, it is arising in: Arising at GE junction, not otherwise specified. Depth of invasion: Adventitia. Number of positive lymph nodes:4/19.. Extranodal metastasis: Unknown.. Specify site:_
+
+--- Page 3 ---
+ PreviOus DiAgnoSis InQuiRy PAGE #: SEX: M REPORT DATF. PATIENT NBR: ADM DATE: NAME: BIRTHDATE: REQ DOC: OPER DATE: ACCESSION: Pattern of invasion: Infiltrative. Esophageal and gastric resection margins involved: No. Deep resection margin involved: No.. TNM classification: T3 N1 MX VERIFIED By: PROCEDURE: 1. Esophagus, excision: Transmurally invasive, poorly-difterentiated. adenocarcinoma with metastasis to four of nineteen lymph nodes. Surgical margins free. No Barrett's mucosa identified. Please see template.. 2. Esophageal margin, excision: No signiticant abnormality. 3. Lower left periesophageal lymph node, excision: Benign fibroadipose tissue, no lymph node present.. igning staft pathologist, have personally. 1. examined and interpreted tne slides from this case. Code: ** END OF PREVIOUS DIAGNOSIS INQUIRY **S
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diff --git a/output/text/1da2061b-a219-43fc-a1d8-c6b89dfe6e06.txt b/output/text/1da2061b-a219-43fc-a1d8-c6b89dfe6e06.txt
new file mode 100644
index 0000000000000000000000000000000000000000..323f26ccf2388112eaeddeacb0532e4cf70bab70
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+UUID:BCDA7E7B-396B-4809-A0B3-28C2C22DC908 TCGA-E9-A54X-01A-PR Redacted Gross Description: There is a fragment of the breast tissue with a tumor up to 1 cm in its diameter. On the edge of the breast tissue there are three isolated lymph nodes. Microscopic Description: Mucinous carcinoma of the breast, G-2. Two examined lymph nodes demonstrated sinus histiocytosis. IHC-stainings: Estrogen receptor - positive reaction 98% 3+; Progesterone receptor - positive reaction 95% 3+; Her-2/neu - negative reaction; Ki67 - 12%. Diagnosis Details: Tumor Features: Indeterminate, Tumor Extent: T1 tumor size 2 cm or less, Venous Invasion: Absent, Margins: Absent, Treatment Effect: Comments: Formatted Path Reports: BREAST TISSUE CHECKLIST Specimen type: Lumpectomy 1c0-0 -3 Specimen size: Not specified c.50.9 Site: bust, nos Tumor site: Breast Tumor size: 1x1x1 cm Grossly evident lesion: Yes Histologic type: Adenocarcinoma, mucinous type. Histologic grade: Moderately differentiated. Tumor extent: Not specified Lymph nodes: 0/2 positive for metastasis (Axillary 0/2). Extracapsular invasion of the lymph nodes: Not specified Margins: Uninvolved. Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified
+
+--- Page 2 ---
+Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Tumor Features: Indeterminate, Tumor Extent: T1 tumor size 2 cm or less, Venous Invasion: Absent, Margins: Absent, Treatment Effect: IHC-stainings: Estrogen receptor - positive reaction 98% 3+; Progesterone receptor - positive reaction 95% 3+; Her-2/neu - negative reaction; Ki67 - 12%. Comments: Breast- left
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diff --git a/output/text/1dbf76d7-af0e-448c-b19b-61e97ac4a29d.txt b/output/text/1dbf76d7-af0e-448c-b19b-61e97ac4a29d.txt
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index 0000000000000000000000000000000000000000..e43e98ec3c801c298c3c899082ec1b7f0915986a
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+--- Page 1 ---
+RUN DATE: RUN TIME: PAGE 1 RUN USER: PATIENT: ACCr #: AGE/SX: REG DR: ROOM DOB : BED: STATUS : SPEC #: RECD : STATUS: COLL : IME IN FORMALIN: 29:21 m's. CLINICAL INFORMATION: Pre-Op Diagnosis: Breast CA Remarks: Specimen(s): Right breast stitch marks axillary contents. zeD o-3 MICROSCOPIC DIAGNOSIS 85QD3 Site. CEC R Bus)uos BREAST. RIGHT. MODIFIED RADICAL MASTECTOMY:S csb.g MULTIFOCAL INVASIVE DUCTAL CARCINOMA ~ SEE COMMENTS oat R Yrss LARGEST TUMOR MEASURES 4 CM: GRADE 2 Jnper xeter ANGIOLYMPHATIC INVASION PRESENT Jt 6[10]13 Kuado C50.4 SEVEN (7) OF EIGHTEEN (18) AXILLARY LYMPH NODES POSITIVE FOR METASTATIC CARCINOMA) WITH FOCAL EXTRACAPSULARY EXTENSION PRESENTS MARGINS NEGATIVE UUID: 5C3D9179-7434-4776-A2FF-68CEA0149C68 TCGA-LL-A6FQ-01A-PR Redacted COMMENT (S) In addition to the two larger tumors present within the upper outer quadrant, a tumor is. also present associated with the nipple measuring 2 cm. This section was evaluated with E-cadherin with appropriate controls demonstrating that the infiltrating carcinoma is. strongly positive for a E-cadherin confirming ductal type. Additionally. a couple of the. lymph nodes were evaluated with PanKeratin stain with appropriate controls. A section from the larger mass was evaluated for a breast prognostic panel. PROTOCOL FOR EXAMINATION OF SPECIMENS WITH INVASIVE CARCINOMA OF THE BREAST PROCEDURE: Total mastectomy LYMPH NODE SAMPLING: Axillary disection SPECIMEN LATERALITY : Right HISTOLOGIC TYPE OF INVASIVE CARCINOMA: Invasive ductal carcinoma (nos) TUMOR SIZE: Greatest dimension of largest focus: 4 cm. HISTOLOGIC GRADE: Nottingham histologic score Glandular ditferentiation: Score 3 Nuclear pleomorphism: Score 2 Mitotic index: Score 1 Overall grade: Grade 2 TUMOR FOCALITY: Multiple foci of invasive carcinoma DUCTAL CARCINOMA IN SITU: No DcIs is present MACROSCOPIC AND MICROSCOPIC ** CONTINUED ON NEXT PAGE **
+
+--- Page 2 ---
+PAGE 2 RUN DATE: RUN TIME: RUN USER: Continued) SPEC # COMMENT(S) (Continued) Skin:  Invasive carcinoma directly invades into the EXTENT OF TUMOR: dermis without skin ulceration MARGINS : Margins uninvolved by invasive carcinoma Distance from closest margin: 3 cm. Number of sentinel lymph nodes examined: 0 LYMPH NODES: Total number of lymph nodes oxamined (sentinel and. non-sentinel): 18 Number of lymph nodes with macrometastasis: 5. Number of lymph nodes with micrometastasis: 2. PATHOLOGIC STAGING: Primary tumor: pT2 Regional lymph nodes: pN2a Distance metastasis: Not applicable ANCILLARY STUDIES: See microscopic description (ER+.PR+.Her2-) GROSS DESCRIPTION: Received fresh for selection of tissue for tissue banking labeled with the patient's name is a modified radical mastectomy specimen. The axillary contents measure 16 x 11 x 4 cm. palpation of which reveals clinically suspicious lymph nodes. The breast weighs 1.457 g and measures 30 x 18 x 6 cm.. Skeletal muscle fibers are present on the deep margin. A large mass is palpated in the upper outer quadrant. The deep margin adjacent to this area is inked blue. The breast is covered by a 30 x 18 cm ellipse of dark brown skin. The nipple and areolar complex is centrally placed. The nipple measures 2.5 cm in diameter and is somewhat firm on palpation.  The breast is serially sectioned revealing a well-circumscribed grayish-white tumor within the upper outer quadrant measuring 3 x 3.5 x. 4 cm. A portion of the tumor is provided to the tissue bank coordinator. The deep margin measures 3 cm.  The tumor lies 1.5 cm from the skin surface. On further evaluation. thore. is an apparent separate tumor in the upper outer quadrant with a core needle biopsy track This tumor is well away from the surgical margins.. and this tumor measures 1.5 x 1 x 1 cm. The remainder of the breast tissue is fatty in nature. No other discrete lesions are. identified. Examination of the axillary contents reveals multiple lymph nodes which range. from 0.5 cm to 3.5 cm in greatest dimension sach. Some of these are grossly involved by tumor. Some are fatty in nature. Cassette Summary: 1 nipple 2 deep margin adjacent to larger tumor. 3-7 sections of larger tumor tissue between larger tumor and smaller tumor. 8 9.10 sections of smaller tumor sections of lateral. central. and medial broast tissue. respectively. 11-13- 14 two highest axillary lymph nodes 15 smaller whole lymph nodes 16-21- one lymph node each sectioned and antirely submitted. 22.23- representative section of two large fatty lymph nodes 24-26- representative section of sach grossly positive lymph node ** CONTINUED ON NEXT PAGE **
+
+--- Page 3 ---
+PAGE 3 RUN DATE RUN TIME RUN USER Continued) SPEC # MICROSCOPIC DESCRIPTION: BREAST PROGNOSTIC PANEL - LARGEST TUMOR INTENSITY RESULTS ASSAY TYPE % TUMOR STAINED 100 3 POSITIVE Estrogen Raceptor. 2 POSITIVE Progesterone Recoptor 85 24 HIGH Ki-67 SCORE 1+ NEGATIVE Her2/nou REFERENCE RANGES: ER/PR: Negative <1%. Positive >=1% : Ki-67; Low <10%, Boderline 10-20%. High >20% : Her2/neu: Negative 0-1+. Equivocal 2+. Positive 3+ Her2/neu results are reflexed to FIsh. All immunohistochemical staining and the were performed at performed scoring and interpretation utilizina Clone PgP1294: Ki-67. Clone MIB-1 Antibody clones: Clone 6F11; Her2/neu. CAP/AscO guidelines for ER and PgR IHc: formalin fixation time 6-72 hours; cold ischemia time 1 hour or less.  CAP/Asco guidelines for Her2 testing: formalin fixation time 6-48. hours: cold ischemia time 1 hour or less. Testing outside of these guidelines may affect. results. INTRAOPERATIVE CONSULTATION: RIGHT BREAST. TISSUE: TUMOR ADEQUATE FOR TISSUE BANKING WITH PORTION OF TUMOR PROVIDED TO TISSUE BANK COORDINATOR Image Image Image Image Signed (signature on file).. ** END OF REPORT * 5/23/3 Hhar
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diff --git a/output/text/1dc0ae7b-e257-4b0f-96cb-e0393944f48b.txt b/output/text/1dc0ae7b-e257-4b0f-96cb-e0393944f48b.txt
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index 0000000000000000000000000000000000000000..2424fb4f983026df2b8a16e011831378bf624c18
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+/CA-0-3 Carcinoma, infiltratig.dutl, N0S 8500f3 SiFe Bust,No5 c5u.q iagnosisDi Procedure Date: Procedure Physician: Attending Physician/Copies To: UUID: 2ED10396-96FF-4705-93AE-82FB9A80EC28 TCGA-BH-A1EY-01A-PR Redacted RATIENT HISTORY: + DATE of LMP: DATE OF LAST DELIVERY: PRE-OP DIAGNOSIS: LEFT BREAST CANCER POST-OP DIAGNOSIS: SAME OPERATIVE PROCEDURE: LEFT MOD RAD MAST CLINICAL HISTORY: MATERIAL SUBMITTED: LEFT (MOD) RADICAL MASTECTOMY, PROCUREMENT BY SURGICAL PROCEDURE INTRAOPERATIVE CONSULTATION: Left Breast - measures 30.0 x 13.5 x 4.5 cm with attached skin ellipse, 19.0  and sectioned with a 4.5 x 4.0 x 4.0 cm tumor, 0.5 cm from posterior margin. x 0.3 cm. Specimen inked FINAL DIAGNOSIS:  DIAGNOSIS: ET BREAST, MASTECTOMY : INVASIVE DUCTAL CARCINCMA; 4.5BY4.O9Y4.0CMGRAD2 -~NOTTINGHAM SCORE 6/9 (TUBULES 2/3, NUCLEAR ATYPIA 2/3, MITOSIS 2/3) - TUMOR IS LESS THAN 1 CM FROM THE DEEP MARGINS ALL OTHER MARGINS ARE FREE OF TUIOR - SKIN AND NIPPLE, FREE OF TUMOR  FOCAL ATYPICAL DUCTAL EPITHELIAL HYPERPLASIA AND FIBROADENOKATOID NOOULES - TWRLVE (12) LYMPH NODES, NEGATIVE FOR TUMORS  MICROCALCIFICATION ASSOCIATED WITH TUMORS - NO LYMPHOVASCULAR INFILTRATION SEENS  BR/PR AND PER-2/NEU RESULTS IMMUNOPEROXIDASE IDENTIFICATION OF ESTROGEN AND PROGESTERONE RECEPTORS IS CARRIED OUT ON SLIDE A3. DISTINCTS INTRANUCLEAR STAINING IS IDENTIFIED FOR BOTH ESTROGEN RECEPTOR (7Ot) AND PROGESTERCNE RECEPTOR (9Ot).S THEREFORE, BOTH ARE INTERPRETED AS POSITIYE.S c-erbB2 (HER-2/NEU) DMXUNOSTAININC IS CARRIED OUT ON BLOCK A3 (BREAST CANCER;) USINC A 1:30O DILUTION OFS DAKO'S POLYCLONAL ANTIBODY A485 (DIRECTED ACAINST THE INTRACELLULAR DCMAIN OF c-OrbB2) WITHOUT ANTICENS RETRIEVAL. DISTINCT COMPLETE MEMBRANE STAINING IS IDENTIFIED IN LE3S THAN 1Ot OF TUMOR CELLS. THEREFORE, C- erbB2 (HER-2/NEU) IS INTERPRETED AS NEGATIVE (SCORE O). NoTe: The special stains and/or imnunoperoxidase tests used in this case have been devaloned and their. performance characteristics determined by the Department of Pathology at
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diff --git a/output/text/1dc3e5db-158c-47df-883f-68c60190d4d1.txt b/output/text/1dc3e5db-158c-47df-883f-68c60190d4d1.txt
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index 0000000000000000000000000000000000000000..ceb58c99f9abf592580b0cba5a9d4b9b52823849
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+--- Page 1 ---
+UUID:6EC48BF8-C9AE-4B53-9DF4-850A5BAC6A6E TCGA-S3-AA0Z-01A-PR Redac Page 1 of 5 Surgical Patholog. Temporary Cop ca Ordere Diagnosis A. SENTINEL LYMPH NODE, BIOPSY: - METASTATIC CARCINOMA IN TWO OF FOUR LYMPH NODES (2/4) B. LEFT BREAST, TOTAL MASTECTOMY: - INVASIVE DUCTAL CARCINOMA, PRESENT AS TWO SEPARATE FOCI AT 12 AND 3 O'CLOCK, 3.5 AND 2.5 CM IN GREATEST DIEMENSION RESPECTIVELY. - MARGINS OF RESECTION ARE FREE OF CARCINOMA. TCD-o-3 - SEE SYNOPTIC REPORT.  sy.ihhrliiy ductNOS C. LYMPH NODES, LEVEL 1 AND 2, LYMPHADENECTOMY: 8sxsl3 - NO TUMOR SEEN IN EIGHT LYMPH NODES (0/8). 0 - SEE SPECIAL STAINS SECTION. Sete Breast, cso.9 Hetr TBusst,mdlere C50.8 (Electronic signature) Verified: MO Q/24l14 Synoptic Report SPECIMEN: Total breast (including nipple and skin). PROCEDURE: Total mastectomy (including nipple and skin). LYMPH NODE SAMPLING: Axillary dissection (partial or complete dissection) SPECIMEN INTEGRITY: Single intact specimen (margins can be evaluated) SPECIMEN SIZE: Greatest dimension: 18 cm. Additional dimensions: 16 x 3 cm SPECIMEN LATERALITY: Left TUMOR SITE: INVASIVE CARCINOMA: Position: 12 o clock(, second mass at 3 o'clock) TUMOR SIZE: SIZE OF LARGEST INVASIVE CARCINOMA: Greatest dimension of largest focus of invasion over 0.1 cm: 3.5 cm TUMOR FOCALITY: Multiple foci of invasive carcinoma. Number of foci: 2 Sizes of individual foci: 3.5 and 2.5. MACROSCOPIC AND MICROSCOPIC EXTENT OF TUMOR: Skin: Invasive carcinoma does not invade into the dermis or epidermis Nipple: DCIS does not involve the nipple epidermis DUCTAL CARCINOMA IN SITU (DCIS): DCIS is present Extensive intraductal component (EIC) negative SIZE (EXTENT) OF DCIS: Estimated size (extent) of DCIS (greatest dimension using gross and microscopic evaluation) is at least
+
+--- Page 2 ---
+Page 2 of 5 Surgical Pathology TemporaryCop. Collected. Orderedby. 0.35 cm ARCHITECTURAL PATTERNS: Cribriform NUCLEAR GRADE: Grade II (intermediate). NECROSIS: Not identified LOBULAR CARCINOMA IN SITU (LCIS): Not identified HISTOLOGIC TYPE OF INVASIVE CARCINOMA: Invasive ductal carcinoma (no special type or not otherwise specified) GLANDULAR (ACINAR)/TUBULAR DIFFERENTIATION: Score 3: <10% of tumor area forming glandular/tubular structures NUCLEAR PLEOMORPHISM: Score 2: Cells larger than normal with open vesicular nuclei, visible nucleoli, and moderate variability in both size and shape MITOTIC COUNT: Score 3 OVERALL GRADE: Grade 3: scores of 8 or 9 MARGINS: Margins uninvolved by invasive carcinoma Distance from closest margin: 5 mm (anterior). Margins uninvolved by DCIS (if present) LYMPH-VASCULAR INVASION: Present DERMAL LYMPH-VASCULAR INVASION: Not identified LYMPH NODES: Number of sentinel lymph nodes examined: 4. Total number of lymph nodes examined (sentinel and nonsentinel): 12 Number of lymph nodes with macrometastases (>0.2 cm): 2  Number of lymph nodes with micrometastases (>0.2 mm to 0.2 cm and/or >200 cells): 0 Number of lymph nodes with isolated tumor cells (less than or equal to 0.2 mm and less than or equal to 200 cells): 0 Size of largest metastatic deposit: 1.1 cm METHOD OF EVALUATION OF SENTINAL LYMPH NODES: Hematoxylin and eosin (H&E), one level  PRIMARY TUMOR (INVASIVE CARCINOMA (pT): pT2: Tumor >20 mm but less than or equal to 50 mm in greatest dimension REGIONAL LYMPH NODES (pN): pN1a: Metastases in 1 to 3 axillary lymph nodes, at least 1 metastasis greater than 2.0 mm DISTANT METASTASIS (M): Not applicable ADDITIONAL PATHOLOGIC FINDINGS: intraductal papillomas, proliferative fibrocystic changes. MICROCALCIFICATIONS: Present in non-neoplastic tissue
+
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+Page 3 of 5 SurgicalPathology nphe TemporaryCop Collected: Ordered by Specimen Source. A Lymph Nodes, Sentinel B Breast Biopsy, Left, Review of Margins C Level 1 and 2 Axillary nodes Clinical Information Patient with multicentric left breast cancer, for mastectomy (12:00 and 3:00), marks lateral breast and lymph. node biopsy PRE-OP DIAGNOSIS: Left breast cancer POST-OP DIAGNOSIS: Same TYPE OF PROCEDURE: Lymph node biopsy, left mastectomy node dissection with immediate reconstruction with tissue expanders Gross Description The specimen is received in two parts.. A. The specimen is labeled "SENTINEL NODE" and is received unfixed for frozen section diagnosis. It consists. of a fibrofatty pink-yellow tissue measuring 3.5 x 2.5 x 1.3 cm. On sectioning there are four lymph nodes. ranging from 0.4-1.5 cm in maximum dimensions. The lymph nodes are entirely submitted in cassettes FS A1 one large lymph node bisected and one small lymph node, FS A2 one lymph node bisected, FS A3 one lymph node bisected Time specimen was removed from the patient: Time specimen was placed in formalin: Ischemic time: 2 hours 9 minutes. Specimen left OR.  at Front desk B. The specimen is labeled "LEFT TOTAL MASTECTOMY" it is reccived unfixed (the specimen is in formalin for more than 6 hours and less than 48 hours). It consists of a 490 g left mastectomy with a suture designated.. lateral breast measuring 18 x 16 x 3 cm. The round skin ellipse measures 5.5 x 4.0 cm in maximum dimensions. The nipple is flat and an unremarkable measures 1.4 x l.4 cm in maximum dimensions. The areolar is dark brown and unremarkable. The fascia is smooth and glistening. The anterior margin is inked red and the deep. posterior margin of resection is inked black. On sectioning, there is an ill-defined cavitated mass surrounded by firm fibrous pink-yellow tissue measuring 3.5 x 2.5 x 2.5 cm. The mass is at 12:00, approximately 5 cm from the nipple, 0.5 cm from the anterior margin and 3.5 cm from the posterior margin. On further sectioning there is a second lobulated firm pink yellow mass measuring 2.5 x 2.0 x 1.2 cm., this mass is at 3:00, approximately 7 cm from the first mass at 12:00, 5 cm from the nipple, 0.6 cm from the anterior margin and 2.3 cm from the deep posterior margin mass. The surrounding breast parenchyma is nodular and shows an area of hemorrhage. previously inked blue. Representative sections are submitted. Section Key: B1 - nipple and skin  B2 - anterior margin and deep posterior margin corresponding to 12:00 mass B3 - B4 random sections of mass corresponding to 12:00 B5 - anterior margin and deep posterior margin corresponding to 3:00 mass  B6 - B7 random sections of mass corresponding to 3:00
+
+--- Page 4 ---
+Page 4 of 5 Surgical.Patl Temporary Cop Collec Ordered by  B8 - random sections of nodular fibrous tissue surrounding the 12:00 mass B9 -- random sections of nodule fibrous tissue surrounding the 3:00 mass. B10 - upper inner quadrant B1l - lower inner quadrant B12 - upper outer quadrant B13 - lower outer quadrant Time specimen was removed from the patient:. Time specimen was placed in formalin: Ischemic time: 40 minutes C. The specimen is labeled "LEVEL I AND II AXILLARY NODES" and is received unfixed. It consists of a nodular fatty yellow-pink tissue measuring 8 x 7.2 x 1.6 cm. On sectioning, there are eight fatty lymph nodes ranging from 0.5-2.5 cm in maximum dimensions. The lymph nodes are entirely submitted.. Section Key: C1 - C2 largest lymph node bisected C3 - one lymph node bisected C4 - one lymph node bisected C5 - one lymph node bisected C6 - two lymph nodes. C7 - two lymph nodes Time specimen was removed from the patient:. Time specimen was placed in formalin: Ischemic time: 3 hours 30 minutes Dictated by: Special Stains / Slides Immunohistochemical studies were performed on formalin fixed, paraffin-embedded tissue (Block C6) with adequate positive and negative control sections.. Cytokeratins AE1/AE3 fail to reveal metastatic carcinoma.. IMMUNOHISTOCHEMICAL EVALUATION OF ESTROGEN RECEPTORS, PROGESTERONE RECEPTORS, AND HER-2NEU IN INVASIVE MAMMARY CARCINOMA, FOCUS AT 12 O'CLOCK (BLOCK B4): ESTROGEN RECEPTORS: 60 %, POSITIVE, STAINING INTENSITY: WEAK TO MODERATE. PROGESTERONE RECEPTORS: 0 %, NEGATIVE. HER-2NEU: SCORE I+, NEGATIVE.
+
+--- Page 5 ---
+Page 5 of 5 Surgical Pathology Final Re Temporary Copy Case: Collected Orderedby: IMMUNOHISTOCHEMICAL EVALUATION OF ESTROGEN RECEPTORS, PROGESTERONE RECEPTORS, AND HER-2NEU IN INVASIVE MAMMARY CARCINOMA, FOCUS AT 3 O'CLOCK(BLOCK B7): ESTROGEN RECEPTORS: 90 %, POSITIVE, STAINING INTENSITY: MODERATE. PROGESTERONE RECEPTORS: 2 %, POSITIVE, STAINING INTENSITY: WEAK HER-2NEU: SCORE 2+, EQUIVOCAL. Immunohistochemical studies were performed on formalin fixed paraffin embedded tissue (Blocks B4 and B7) using the following monoclonal antibodies: Estrogen receptor (Clone SP1), Progesterone receptor (Clone 1E2) and Her-2neu ( Clone 4B5); control sections for HER-2Neu are provided within a kit (score 0 MCF-7,. score 1+ T-47D, score 2+ MDA-MB-453, score 3+ BT-474). Detection system used: polymer. Primary antibodies, reagents and control sections for HER-2neu are all provided by. All controls show appropriate reactivity. Reactivity of Estrogen and Progesterone receptors is determined based on the percentage ofpositively  stained nuclei of tumor cells. Reference values (CAP accreditation program checklist 2010 and guidelines on webpage): Positive: nuclear staining in 1% or greater than 1% of invasive carcinoma cells Negative : nuclear staining in less than 1% of invasive carcinoma cells. Staining intensity: is reported as weak, moderate or strong.. HER-2neu reactivity is reported applying the CAP scoring guidelines (CAP accreditation program checklist 2010 and guidelines on webpage): Score 0 -- Negative: No immunoreactivity, or faint weak immunoreactivity in <10% of tumor cells but only a portion of the membrane is positive.. Score 1 = Negative: Faint weak immunoreactivity in 10% or >10% of tumor cells but only a portion of the membrane is positive. Score 2+ - Equivocal: Weak to moderate complete membrane immunoreactivity in >10% of tumor cells or circumferential intense membrane staining in <30% of cells.. Score 3+ = Positive: More than 30% of the tumor cells must show circumferential intense and uniform membrane staining. A homogeneous (chicken wire) patterm should be present. Equivocal results for HER-2neu (Score 2+) will be subsequently followed by a reflex dual-color ISH testing. The performance characteristics of these antibodics were determined by the. . They have not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not nccessary. These tests are used for clinica! purposes. They should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA-88) as qualified to perform high-complexity clinical laboratory testing.. 6 FS, 23 H&E,7 IHC Tissue Code.
+
+--- Page 6 ---
+Page 1 of 1 Collect Addendum Report ASSAY PERFORMED: HER2 GENE AMPLIFICATION BY DUAL IN SITU HYBRIDIZATION USING THE INFORM HER2 Dual ISH DNA PROBE COCKTAIL 20 Number of nuclei scored: Total HER2 signals: 42 Total CHR 17 signals: 33 HER2/CHR 17 ratio: 1.3 INTERPRETATION: -/NEGATIVE FOR HER2 GENE AMPLIFICATION. NOTE: THE ASSAY WAS PERFORMED AS A REFLEX TEST AFTER THE HER2/NEU IMMUNOSTAIN WAS 2+. SPECIMEN TYPE: The HER2 Dual ISH DNA is performed on a formalin-fixed paraffin-cmbedded tissue slide from block B7. DESCRIPTION OF THE ASSAY: The HER2 Dual ISH DNA Probe assay enables the HER2 gene and Chr17 centromere to be co-hybridized and visualized via light microscopy. on the same slide. Specifically for this assay, HER2 is detected by a dinitrophenyl (DNP) Iabeled probe. visualized utilizing SISH DNP (silver in situ hybridization) detection kit. The Chr17 centromere is targeted with a digoxigenin (DIG) labeled probe and detected using. Red ISH DIG detection kit. Dual ISH staining results in visualization by light microscopy and which HER2 appears as discrete black'signals (SISH) and Chr17 as red signals in nuclei of normal cells serving as intemal positive control for staining) as well as in carcinoma cells.. SLIDE SCORING: Once an adequate target area is identified the reader records the scores for HER2 and Chr17 copy numbers that are present in 20 representative nuclei. If the resulting HER2 / Chr17 ratio falls within 1.8-2.2 (EQUIvOCAL) the reader is recommended to score an additional 20 nuclei and the resulting ratio is calculated from the total 40 nuclei. HER2 gene status is reported as non-amplified (HER2/ Chr17 < 2.0) or amplified (HER2/Chr17  2.0). The performance characteristics of this assay were determined by the This assay has been approved by the U.S. Food and Drug. Administration. This Iaboratory is certified under the Clinical Laboratory Improvemcnt Amendments of 1988 (CLIA-88) as qualified to  perform high-complexity clinical laboratory testing. cpt: 88368 x2 (Electronic signature) Verified:
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diff --git a/output/text/1dc52e02-9af3-46f9-bd85-a5b8adcc9419.txt b/output/text/1dc52e02-9af3-46f9-bd85-a5b8adcc9419.txt
new file mode 100644
index 0000000000000000000000000000000000000000..547f55c3d30bf7d5a9c1df25c186a391eef5cf2a
--- /dev/null
+++ b/output/text/1dc52e02-9af3-46f9-bd85-a5b8adcc9419.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Final Diagnosis: Part 1: breast, Left, 12 O'clock, needle Localized excisional biopsy - A. ATyPICAL DUCTAL EPiTHELIAL HYPERPLASIA (see comment). B. COMPLEX PAPILLARY PROLIFERATIVE LESIONS.E C. Ductal epithelial hyperplasia. D. ADENOSIS AND SCLEROSING ADENOSIS. E. COLUMNAR CELL CHANGES AND HYPERPLASIA WITH ASSOCIATED MICROCALCIFICATIONS. FIBROCYSTIC CHANGES WITH APOCRINE METAPLASIA. G. DUCT ECTASIA. H. MICROSCOPIC RADIAL SCARS. MARKED CauTERY ArTiFaCT. J. BIOPSY RELATED CHAnGES. Part 2: breast. Right. 9,O'clock, needle Localized Segmental mastectomy --  invasive Ductal Carcinoma with Lobular features, 3.2 Cm (gross), nOttingham graDe 2/3 A. (COMBINED NOTTINGHAM SCORE 6/9: TUBULE FORMATION 3/3, NUCLEAR ATYPIA 2/3, MITOTIC ACTIVITY 1/3) (see comment). B.  DEFinITiVE DUcTAL CARCINoMA IN SITU iS nOt IDEnTIFIeD. C. EXTENSIVE LYMPHOVASCULAR INVASION. D.  margins free, closest medial, Anterior, deep and inferior within O.5 Cm. E ATYPICAL DUCTAL EPITHELIAL HYPERPLASIA. F. FIBROCYSTIC CHANGES. G. InTRADUCTAL PAPILLOMA. H. BIOPSY SITE CHANGES. I. MARKED CAUTERY ARTIFACT. J.  PATHOLOGIC STAGE (see comment). UUID:9714A9F8-8507-43E6-9D56-1852F5D1F675 TCGA-bH-A0BC-01A-Pr Redacted Part 3: Breast, right, new margin, excision -- A. COMPLEX PAPILLARY PROLIFERATIVE LESION. B. DUcTaL EPITHeLial HYPERplASIA. C. ADENOSIS AND SCLEROSING ADENOSIS. D. COLUMNAR CELL CHANGES AND HYPERPLASIA. E. FIBROCYSTIC CHANGES WITH APOCRINE METAPLASiA F. Duct ectaSiA. G. MARKED CAUTERY ARTIFACT Part 4: sentinel Lymph nOde # 1, right, biopsy - A.  MEtASTaTiC CARciNOMA INVOLVING ONe LymPh nODE B.  metastatic focus, 1.2 Cm in greatest Diameter (entire Lymph node). C. Extracapsular extension is Identified, 0.5 Cm x 0.2 Cm. CASE SYNOPSIS: SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST LATERALITy: Right PROCEDURE: Segmental LOCATION: Not specified SIZE OF TUMOR:  Maximum dimension invasive component: 3.2 cm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: No 100-0-3 TUMOR TYPE (invasIve component): Curinonx mfilthsttwg ductd,nrs 850o/3 Ductal adenocarcinoma, NOS nOTTinGhAm SCOrE: Nuclear grade: 2 Sit:brest Nos C50.9 3/3/n h Tubule formation: 3 Mitotic activity score: 1 Total Nottingham score: 6 Nottingham grade (1, 2, 3): 2 ANGIOLYMPHATIC INVASION: Yes DERMAL LYMPHATIC iNVASION:  Not applicable CALCIFICATION: Yes, benign zones 'riteria SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: iagnosis Disc No SURG MARGINS INVOLVED BY IN SITU COMPONENT: No se iscircie LYMPH NODES POSITIVE: 1 LYMPH NODES EXAMINED: METHOD(S) OF LYMPH NODE EXAMiNATION: H/E stain SIZE OF NODAL METASTASES: Diameter of largest lymph node metastasis: 15.0 mm LYMPH NODE METASTASIS(-ES) WITH EXTRACAPSULAR EXTENSION: Yes NON-NEOPLASTIC BREAST TISSUE: ADH t Stage, PathologiC: pT2 N Stage, pathologic: pN1 M Stage, Pathologic: pMX ESTROgeN RECEPTOrS: positive Progesterone receptors: positive HER2/NEU: zero or 1+
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diff --git a/output/text/1dd40057-7d99-4106-b368-6f6b65c2adfc.txt b/output/text/1dd40057-7d99-4106-b368-6f6b65c2adfc.txt
new file mode 100644
index 0000000000000000000000000000000000000000..227d1f1174c66771701208c9990b875b4b788762
--- /dev/null
+++ b/output/text/1dd40057-7d99-4106-b368-6f6b65c2adfc.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:A214150E-54BD-499D-A56D-082BAC861668 TCGA-OR-A5JM-01A-PR Redacted EcD-o-3 'Crcinomo-, Odreuab csrtreaI |Sex: F 8370/3 Site: Adruas 6hue,cortex. Specimen : Tissue c74D 9D1|ssfi3 HISTORY: 1. Left upper quadrant. 2. Subsequent 3 liver. 3. Retroperitoneal fat behind tumour. MACROSCOPIC: A. "LEFT UPPER QUADRANT MASS". A spleen, pancreas and kldney attached to a tumorous mass. The tumorous mass measures 100mm from superior to inferior, 80mm from medial to lateral and 9omm from anterior to posterior. The External surface of the tumorous mass is multilobulated and vascularised. In one of the areas there is a defect which corresponds to a piece of tissue taken for med!cal research. The tumorous mass is Iocated aside the spleen, posterior from the pancreas and superior from the kidney. The mass is located on the anatomical place of the adrenal gland. On sectioning the tumour is white yellow with areas of haemorrhage and central necrosis . within the tumour the adrenal gland is identified. Macroscopically the tumour is attached to the perirenal fat but does not involve the kidney. The segment of pancreas attached to the tumour measures 65mm in maximum length and 35mm in maximum diameter. Macroscopically it is not. involved by the tumour. The spleen measures 150mm from superior to inferior, 90mm from anterior to posterior and 7omm from medial to lateral. The serosal surface is shiny. and granular. The cut surface is unremarkable . The left kidney measures 111mm from superior to inferior, 7Onm from middle to lateral and 30mm from anterior to posterior. The serosal surface is shiny. The cut surface is unremarkable.. (1-3 tumour; 4&5 tumour with adrenal gland; 6 pancreas section margin; 7 pancreas with fat adjacent to tumour; 8 spleen with: fat adjacent to the tumour; 9 spleen; 10 kidney; 11 perirenal fat adjacent to the tumour). Further tissue: 12 ureter section margin and section margin of rena! hilar vessels, 13-14 kidney renal pelvis.15-16  pancreas. B. "sEGMENT 3 LIVER". A piece of liver measuring 60x50x30mm. On sectioning there is a nodular white firm tumour measuring 20x20mm. It is located 10mm from the surgical margin. C. "PERI-PERITONEAL FAT BEHIND TUMOUR". An irregular piece of fat tissue Distribution:FILE-COPY, SANCER-REGISTRY Page 1 of 2
+
+--- Page 2 ---
+measuring 80x35x5mm. No tumour deposits are identified. MICROSCOPIC: A. The sections show adrenal gland from which arises a lobulated tumour composed of nests and fascicles of calls with intervening sinusoidal vascular pattern. There is moderate to severe nuclear pleomorphism and with broad areas of necrosis. Nuclear hyperchromasia and granular chromatin is present with nucleoli In many cells. Cytoplasm. is pale to eosinophilic and in some areas somewhat vacuolated. There are up to 18. mitoses per 10/hpf. There is infiltration into periadrenal adipose tissue and there is also invasion into adrenal hilar vein. The tumour abuts the inked margin in many areas. Sections of the spleen are unremarkable. The pancreas and pancreatic resection margin are unremarkable apart from patchy pancreatic degeneration at the pancreatic resection * margin. The sectian of the kidney is unremarkable.. IMMUNOHISTOCHEMISTRY: There is positive staining for Melan-A and inhibin (patchy). The stains for calretinin, EMA, CAM5.2, and AE1/AE3 are negative.. B. The sections show liver with a deposit of tumour with features identical to that seen in specimen A. The tumour abuts the liver capsule but does not penetrate to capsular. surface and appears clear of the diathermied surgical margin of the liver.. C. The sectlons show adipose tissue. There is no evidence of malignancy. COMMENT: The appearances are those of adrenal cortical carcinoma. DIAGNOSIS: A. LEFT UPPER QUADRANT MASS - ADRENAL CORTICAL CARCINOMA. B. SEGMENT 3 LIVER - ADRENAL CORTICAL CARCINOMA. C. PERITONEAL FAT BEHIND TUMOUR - NEGATIVE FOR MALIGNANCY. REPORTED BY : AUTHORISED BY : 33 DISEASE Codes :T-B3000,M-83703 Page 2 of 2
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diff --git a/output/text/1dff4dcd-d218-47c1-be62-1fb802f4e9ad.txt b/output/text/1dff4dcd-d218-47c1-be62-1fb802f4e9ad.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ead203c28f6def8a5b7c1cead863c2fa8ec5fb76
--- /dev/null
+++ b/output/text/1dff4dcd-d218-47c1-be62-1fb802f4e9ad.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+ UUID:50782829-35B6-4A61-A3CE-F105A31EDB42 TCGA-A7-A13G-01a-PR  Redacted ica -0-3 Careiomnn - lnfi1tnatng Auct, NOs 8500|3 SPECIMEN A. Left axiliary sentinel node Sits: brnstNos C5o.9 B. Left breast, silk suture on superior breast CLINICAL NOTES PRE-OP DIAGNOsIS: Left breast cancer. CLINICAL HISTORY: -year-old female with grade 1 IDC. POST-OP DIAGNOSIS: Left breast cancer. FROZEN SECTIGK DIAGNOSIS A. Lymph node negative for metastatic disease.. GROSS DESCRIPTION A. Part A is received fresh for frozen section labeled "left axillary sentinel node". It consists of three portions of adipose tissue measuring 2.3 x 2.2 x 1 cm in aggregate. Within the fat a single fatty tan lymph node is found measuring 1.7 x 0.6 x 0.4 cm. The node is bisected and all submitted in one block. B. Received fresh for tissue procurement labeled "left breast" is a 19.5 cm (medial to lateral) x 13.8 cm (superior to inferior) x 2 cm (anterior to posterior) diffusely cauterized soft, lobulated tan gold-white portion of fibroadipose tissue in keeping with breast designated as left per requisition slip and container and oriented by . a single suture as stated. previously. There is a 14.5 cm (medial to lateral) x 4.3 cm (superior to inferior) wrinkled white skin ellipse with diffuse red-purple ecchymosis and a central,  slightly flattened, 1.7 x 1.7 x 0.4 cm nipple along the anterior aspect..  The intact deep margin is. inked black and the specimen is sectioned. There is a moderately well circumscribed, 2.8 cm (medial to lateral) x 1.8 cm (superior to inferior) x 1.6 cm (anterior to posterior) rubbery tan-white lesion at the junction of the lower inner and outer quadrants.  The lesion focally extends to within 0.6 cm of the inked deep margin and is 1 cm from the anterior surface (subsequently inked blue). A few cylindrical firm tan-white structures in keeping with site of prior needle core biopsy are evident. A portion of tumor and a portion of. normal breast are submitted for tissue procurement as requested. The cut surfaces throughout the remainder of the specimen consist predominantly of glistening lobulated golden yellow adipose tissue with a minimal amount of interspersed delicate tan-white fibrous tissue. No additional mass lesion or abnormality is identified. Representative sections are submitted in twelve blocks as labeled. RS-12. BLOCk suMMARy: 1-3 - Tumor to inked deep margin; 4 - tumor to anterior surface; 5,6 - tumor to adjacent parenchyma; 7 - random upper-outer quadrant; quadrant; 1l - junction of the four quadrants; 12 - nipple. MICROSCOPIC DESCRIPTION A.  This single lymph node is examined microscopically in its entirety and at multiple levels. It is negative for metastatic disease, 0/1. B. This simple mastectomy specimen contains a central, fairly well demarcated infiltrating low grade ductal carcinoma. No definite ductal carcinoma in' situ is present. Invasive Carcinoma: Histologic type: Infiltrating ductal carcinoma. Histolcgic grade: weli differentiated Overali grade: Elston sBR grade 1. Architectural score:
+
+--- Page 2 ---
+Nuclear score: 1-2 Mitotic score: 1 Greatest dimension (pT): The tumor measures 2.8 cm., pT2 Specimen margins: Negative. Vessel invasion: Negative. Calcification: Present Nipple (Paget's): Negative for Paget's disease. Invasion of skin or chest wall: Negative. Description of non-tumorous breast: Fibrocystic changes are present including cysts, apocrine metaplasia, ductal hyperplasia, intraductal papillomatosis, rare focus of atypical ductal hyperplasia and rare focus of atypical lobular hyperplasia. A 1 cm.. fibroadenoma is also noted. Lymph nodes: As per part A, a single lymph node is negative for metastatic disease. (pN0) Distant metastasis (pM): Cannot be assessed. Prognostic markers: Previously performed.. 14, 4x2 DIAGNOSIS A. Left axillary sentinel node, excision - Single lymph node. negative for metastatic disease. B. /Left breast, simple mastectomy - Breast with infiltrating .ductal. carcinoma, Elston sBR grade 1. Margins of resection, skin and nipple negative for tumor. Fibrocystic changes, rare atypical ductal hyperplasia and rare atypical lobular hyperplasia also present. A 1 cm. fibroadenoma is noted.. DIAGNOSIS M.D. (Electronic Signature)
\ No newline at end of file
diff --git a/output/text/1e064cf7-9be6-43bb-b14d-4421b9f4d70e.txt b/output/text/1e064cf7-9be6-43bb-b14d-4421b9f4d70e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a54f92ddba52b26d5c4634da975cbf09cff2d33b
--- /dev/null
+++ b/output/text/1e064cf7-9be6-43bb-b14d-4421b9f4d70e.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+PARt 1: hIGhEST LymPH nODE, RIGHT hEMICOLECTOmy  ONE (1) LYMPH NODE NEGATIVE FOR MALIGNANCY. PART 2: RIGHT COLON AND PORTION OF TERMINAL ILEUM, HEMICOLECTOMY - A.  POORLY DIFFERENTIATED CARCINOMA OF CECUM, EXTENDING THROUGH MUSCULAR WALL AND SEROSAL ADIPOSE TISSUE TO REACH THE PERITONEAL SURFACE (see Comment). B.  SurGICal margINs FrEE Of TumOr. C. FIVE/THIRTY (5/30) LYMPH NODE POSITIVE FOR MALIGNANCY. D.  POSITIVE VASCULAR INVASION BY TUMOR. E. pT4, N2, M1, DUKES' 3, ASTLER-COLLER GRADE: 6. F. DIFFUSE QUIESCENT COLITIS WITH MILD ATROPHY IN KEEPING WITH ULCERATIVE COLITIS (see comment). G. ONE (1) PSEUDOPOLYP SHOWING ULCERATION AND ACUTE AND CHRONIC INFLAMMATION. H. APPENDIX WITH NO SIGNIFICANT PATHOLOGIC CHANGE. PART 3: LIVER, BIOPSy -- METASTATIC POORLY DIFFERENTIATED ADENOCARCINOMA A. Location: 1 1.  Hleocecal Region 4. Descending Colon 2. Ascending Colon 5.  Sigmoid Colon  Transverse Colon 6. Rectum  Procedure: 1 1. Segmental Colectomy 3. Other 2. Total Colectomy C.  Size of Tumor (maximum dimension): 4.0 cm D. Type: 1 1. Adenocarcinoma, NOS 9. Squamous Cell Carcinoma 2.  Adenocarcinoma arising in a background 10. Undifferentiated Carcinoma Of an adenoma. 11. Sarcoma 3. Adenocarcinoma arising in a background 12. Smooth Muscle Tumor of inflammatory bowel disease 13. Gastrointestinal stromal tumor 4. Adenosquamous carcinoma 14. Lymphoma Carcinoid Tumor (Neuroendocrine Tumor) 15. Other 6. Mucinous Adenocarcinoma 7. Signet ring cell type Adenocarcinoma  Neuroendocrine Carcinoma E. Grade: 3 1. Well differentiated 2. Moderately differentiated 3. Poorly differentiated Extent of Infiltration: 5  Limited to the mucosa 4. Infiltrating through muscularis propria into serosal 2.  into submucosa adipose tissue 3. Involving muscularis propria 5. Involving adjacent organs/ pelvic wall G.  Angiolymphatic Invasion: 1. Yes 2. No H. Surgical Margins Involved: 2 1. Yes 2. No 1. Number of positive lymph nodes:  5  Total number of lymph nodes examined: 30 K. Extracapsular spread : 2 1. Yes 2. No. L. Associated conditions: 1 1. Uicerative colitis. 2. Crohn's Disease. 3.  History/ presence of adenomatous polyps. 4. Multiple polyposis syndromes. 5. Diverticulosis. M. TNM Stage: T4 N2M 1 N. Dukes' Stage: 3 A (limited to mucosa and muscularis) 2. B (through muscularis into subserosa) 3. C (affecting lymph nodes) D (metastatic) O. Astler-Coller Stage: 6 1. 2. B1 (muscularis propria but not through to subserosa)  B2 (through muscularis propria into subserosal fibroadipose tissue, LN negative)  C1 (limited to muscularis propria but not through subserosa, LN positive) 5. C2 (invades serosal adipose tissue. LN positive) 6. D (metastatic disease)
\ No newline at end of file
diff --git a/output/text/1e2d757b-7e13-4146-a8e1-18b854781322.txt b/output/text/1e2d757b-7e13-4146-a8e1-18b854781322.txt
new file mode 100644
index 0000000000000000000000000000000000000000..568d56b9cebf2ce248e088cad23ba580ac2046f5
--- /dev/null
+++ b/output/text/1e2d757b-7e13-4146-a8e1-18b854781322.txt
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+
+--- Page 1 ---
+TCGA--DU-5852 Surgical Pathology Report aken: Received: Reported: CLINICAL HISTORY The patient with Currently the patient has a lucent, circumscribed lesion in the parahippocampal. gyrus. and hippocampus, which on FLAIR involves nearly the entire temporal 1obe. OPERATIVE DIAGNOSES Epilepsy Operation/Specimen: A: Brain,medial temporal tumor, biopsy. B: Brain, posterior tumor, biopsy. PATHOLOGICAL.DIAGNOSIS: A. Brain, medial temporal tumor, biopsy: Anaplastic oligoastrocytoma (WHO Grade III) (see comment). B. Brain, posterior tumor, biopsy: Anaplastic oligoastrocytoma (who. Grade III) (see comment). COMMENT Permanent sections are in keeping with agreement of the frozen section diagnoses. Sections of A. and B. show a proliferation of moderately pleomorphic round to oval and occasionally angular cells. Infiltrate cortex shows perineuronal tumor cell satellitosis. Scattered mitotic figures are identified. Vascular proliferation and necrosis are not seen. Immunohistochemical stains performed on part B. show positive GFAP staining of reactive astrocytes and. occasional tumor cells, some of which show a thin rim of perinuclear staining. Corresponding. slides for this case are also reviewed.
+
+--- Page 2 ---
+Overall'.the tumor is most consistent with an anaplastic oligoastrocytoma, with the.oligodendroglial. component being dominant. The Ki-67 labeling index is up to approximately 12%. Positive and negative controls show appropriate immunoreactivity. Molecular studies show that the tumor is negative for 1p,19q Loh and positive for MGmr promoter methylation (see procedure addenda below). PROCEDURES/ADDENDA Loss of Heterozygosity 1p, 19q Assay Date Ordered: Date Reported: Interpretation NEgAtive: Allelic loss on chromosome arm 1p and chromosome arm 19q is NOT. . detected. Informative loci are: D1s1592, D1s552, D1s468, D1s1612, D1s496, PLA2G4C, D19S606 and D19S1182 Results-Comments Testing performed on DNA extracted from tumor paraffin block. DNA extracted from'a corresponding blood specimen was used as normal reference control. TEST DEscRIpTIoN: Allelic loss is assessed by PcR assay in Normal DNA (baseline)/ Tumor DNA pairs using 3 markers at both 1p and 19q. The 3 markers on.1p are D1s548, D1s1592, and D1s552 (with D1s468, D1s1612, and D1S496 as backup markers) and the 3 markers on 19q are D19s219, D19s412, and PLA2G4C (with D19s606. and D19sl182 as backup). All markers are microsatellites (2 or 4 nt.repeats) except PLA2g4c which is a minisatellite (26 nt repeat) polymorphism. The markers were selected based on heterozygosity score, amplicon size, and ease'of interpretation. The backup markers are used if:the first line markers at that chromosome arm are uninformative or otherwise
+
+--- Page 3 ---
+ambiguous.in their interpretation. Loh at all informative loci on each chromosomal arm represents the typical finding in oligodendrogliomas with 1p and 19q deletion. FDA coMmENT: :The above data are not to be construed as the results. from 'a stand-alone diaqnostic test. This test was developed and its performance characteristics determined by the as required by regulations. It has not been cleared or approved for specific uses by the U.s. Food and Drug Administration (FDA). The FDA has determined that such clearance or approval is not necessary. These. results are provided for informational purposes only, and should be interpreted. only in the context of established procedures and/or diagnostic criteria.  TECHNICAL SENSITIviTy: The presence of >15% non-neoplastic cells in the sample may preclude the detection of allelic loss. Eernic ianed Ouf* Date.Ordered: Date Reported:. Interpretation. POsITivE: Methylated MGmT promoter is detected. Results-Comments Testing performed on DNA extracted from tumor paraffin block TEsT DEscRIpTIoN: Patients with glioma containing a methylated MGMT promoter have. been shown to benefit from therapy with alkylating agents. Assessment of MGMT promoter methylation status involves bisulfite treatment of DNA followed by real-time PcR amplification (MethyLight) of methylated and unmethylated DNA sequences. The analytic sensitivity of this assay was determined by serial dilution of methylated positive control DNA into unmethylated DNA, and was:: assessed to be 1% of methylated DnA in the background of unmethylated. DNA.. Factors such as the presence of >50% non-neoplastic cells in the sample, or extensive tissue'necrosis, may preclude the detection of methylated MGMT : promoter sequences.
+
+--- Page 4 ---
+FDA commeNT:*The above data are not to be.construed as the results from'a' stand alone diagnostic test. This test was developed and its. performance characteristics determined by the laboratory as required by It has not been cleared or approved for specific uses by the U.s. Food and Drug Administration (FDA). The FDA. has. determined that such clearance or approval is not necessary. These results are. provided for informational purposes only, and should be interpreted. only in the:.context of.established procedures and/or diagnostic criteria.. Logy INTRA-OPERATIVE CONSULTATION A: Brain,medial. .temporal tumor, biopsy: Cerebral cortex, and white matter, not. diagnostic. There is not lymphoma. Firm blood clot, grossly. More tissue will be submitted.. Touch preparation smears performed at and results reported to the Physician of Record.. Posterior tumor, biopsy: 1, : Hypercellular tissue, small cells (R/o glioma, other...). Touch preparation smears performed at and results reported to the Physician of Record. 2.:  Hypercellular tissue, slight atypia (R/o infiltrative process, glioma? other) More tissue will be available Frozen section performed and results reported to the Physician of Record. GROSS DESCRIPTION A: "Medial temporal tumor," received fresh, three fragments, 0.8 cm in aggregate.s Semi firm, 'tannish-white. In total, Al. B "posterior'tumor," received fresh, multiple fragments, 1.4 x 1.5 x 0.9. cm in aggregate. ..Semi firm, tannish-grey, focally hemorrhagic. Fragment of. leptomeninges with engorged vessels. In total, B1-B3, frozen tissue B4.
+
+--- Page 5 ---
+ICD-9(s): 345.11 345.11 Billing Fee Code(s) : Histo Data Part' A: 'Brain,medial temporal tumor, biopsy Taken: Received: Stain/cnt Block Ordered Comment H/E'x 1 1 TPS H/E x 1 1 Part B] biopsy Taken: Received: Stain/cnt Block Ordered Comment FS H/E x 1 1 mGFAP-DA x 1 H/E x 1 1 LOH-curls x 1 1 MGMT-curls x.1 y MIB1-DA x 1 1 TPS Triage x ] 1 H/E x 1 2 H/E.x 1 3 mGFAP-DA x 1 4 H/E x 1 4 MIB1-DA x 1 *** End of Report
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diff --git a/output/text/1e4e0dd7-14a1-455a-950c-15c18624e7b5.txt b/output/text/1e4e0dd7-14a1-455a-950c-15c18624e7b5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3e510d5957d55af6d354b596bfc4ffd9666efc5c
--- /dev/null
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+
+--- Page 1 ---
+UUID:64D878AE-DEEA-4C56-854C-3774038E2914 TCGA-DD-A4ND-01A-PR Redacted TISSUE DESCRIPTION: A1 A2 A3 A4 A5 A6 A7 A8 A9 A1O Al1 A12 A13 Left lobe liver (915.0 grams, 13.5 x 13.0 x 8.0 cm). DIAGNOSIS: Liver, left lobe, resection: Grade 3 (of 4) hepatocellular carcinoma forms a 13.0 x 13.0 x 7.5 cm intrahepatic mass with focal necrosis. No vascular invasion identified. Margins of resection negative for tumor (closest margin 1.2 cm). Uninvolved liver is noncirrhotic IcdO-3 Carcinoma, hepatcelllar Nos 8 i7o13 Si+e: Liver CQ2.0 Aw 1a/24/12
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diff --git a/output/text/1e5dd344-7007-4124-9043-d5d1bcb81760.txt b/output/text/1e5dd344-7007-4124-9043-d5d1bcb81760.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0e70ea6f67b68069938c50f84af08a720d620f5a
--- /dev/null
+++ b/output/text/1e5dd344-7007-4124-9043-d5d1bcb81760.txt
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+
+--- Page 1 ---
+zcD-o-3 Carcinoma. Adrenal UUID:57A7E2E6-2108-41B1-8C22-9E04930BCDEA Cortical '8370/3 Redacted Site : Adrenal Gbd Cortex 074.0 J 2%/13 Procedure: Right adrenalectomy. Gross description: Adrenal tumor is 254g; measuring 12 x 6 x 6.5cm. Diagnosis: Adrenal cortical carcinoma. Weiss score = 7. No LN mets (+0/32) n iu/
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diff --git a/output/text/1e6d0fe4-437d-4212-b286-3ed0f4b04826.txt b/output/text/1e6d0fe4-437d-4212-b286-3ed0f4b04826.txt
new file mode 100644
index 0000000000000000000000000000000000000000..982425824d785378756a6ee405d9e809f963c5f5
--- /dev/null
+++ b/output/text/1e6d0fe4-437d-4212-b286-3ed0f4b04826.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Jcs-0-3 Carcnoma, hepat cellulr, Nos 817o/3 - ID#: sit: Lwvn cx2.0 1/ofn h Pathology Form Specimen Information Collected by: . Date: ime: .ime. Preserved by: Date  Blood/Seru m/Plasma Slide Frozen Paraffin Block Diseased Normal Diseased Normal Diseased  Normal Diseased Normal 2 2 4 2. Time to Formalin Time to LN2 Time to LN2 min min min 1 2 M T PATHOLOGICALDESCRIPTION  + Primary Tumor Size Extension of Tumor Distance to NAT Organ Zumar cm isr 15 x/2+xA cm Lymph Nodes # Metastasized Location # Examined Distant Metastasis Size Organ Detailed Location Pathological Staging No m o Stage: II pT 3 Notes: UUID: 3136CA38-995E-4B6B-97F2-D37AF68EFA4C CGA-CC-5263-01A-PR Redacted
+
+--- Page 2 ---
+ID#: Microscopic Description .+  *  a Histological Pattern   Cell Distribution + Structural Pattern + Diffuse +  Streaming  Mosaic  Storiform Necrosis Fibrosis Lymphocytic Infiltration  Palisading Vascular Invasion Cystic Degeneration Clusterized Bleeding  Alveolar Formation. Myxoid Change  Indian File Psammoma/Calcification awyotnsCelularDifferentiationpt.  Squamous Adenomatous + Sarcomatous + Lymphomatous I +  Squamoid Cell Glandular celf Round Cell  Large Cell Spindle Cell  Cell Stratification  Fibroblast Small Cell  Keratin Secretion  Osteoblast  RS Cell/RS Like  Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell Pear  Gland formation Myoblast Plasma Cell Cellular Differentiation: Well Moderate (X) Poor ++++ *+** NuclearAppearance+++++*s*++a***+* Nuclear Atypia: 0 1 1I III  Aniso Nucleosis Hyperchromatism  Nucleolar Prominent  Multinucleated Giant Cell  Mitotic Activity Nuclear Grade: wwww.w.HcDatawpw. Value Date  Marker Resuit ER  Negative  Positive PR  Negative   Positive Her-2/neu  Negative   Positive B-Cell Marker Negative  Positive T-Cell Marker  Negative   Positive Other:  Negative   Positive Other:  Negative   Positive Final Pathology Report. Histological Diagnosis: HeDale cercinomd Mickegtely diteRep Zitted Grade:T T 3NyMpY!=sT@ge  A Comments: ; vaie  Principal Investigator Pathologist 5
+
+--- Page 3 ---
+CONSOLIDaTED DIAgNOsTIC PAThOLOgy fORm* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION  Diffuse STRUCTURAL PATTERN Streaming Mosaic  Storiform Necrosis x Fibrosis Lymphocytic Infiltration x Palisading Vascular Invasion X Cystic Degeneration Clusterized N Bleeding Alveolar Formation Myxoid Change Indian File Psammoma/Calcification 2. Cellular features: Squamous + Adenomatous +  Sarcomatous Lympbomatous  Sguamoid Cell Glandular cel! +  Round Cell Large Cell Spindle Cell Cell Stratification Fibroblast Small Cell  Keratin  Secretion Osteoblast  RS CeIl/RS Like  Desmosome Intracyt. Vacuole Lipoblast Inflam. Cell Pearl Gland formation 171 Myoblast  Plasma Cell Otherwise Specified: Vj 707t 0rJ8Z D3 7oZ D4 2s7c %eesoep /O 2.Cellular Differentiation: Well Moderately Poor Nuclear Atypia: Nuclear Appearance  Aniso Nucleosis x Hyperchromatism M Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity Nuclear Grade X Histological Diagnosis: Aepatr ce//u ler Cerensrmg, Ce  Comments: Date ) PATHOLOGIST STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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diff --git a/output/text/1e8ea939-9d33-4972-b09c-53ac316c8243.txt b/output/text/1e8ea939-9d33-4972-b09c-53ac316c8243.txt
new file mode 100644
index 0000000000000000000000000000000000000000..47ea16acc8a8ea9c029cc55f0ea3975ec861816b
--- /dev/null
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+
+--- Page 1 ---
+HISTORY: History of oral tongue squanous cell carcinora. Cperative Procedure/Tissue Submitted: Glossectomy GROSS: "Right level II, external jugular lymph node' A 0.8 cm tan lyrph node. lA. Frozen section control. (lns, fat retained) 'Subrental deep anterior. margin' A 0.8 x 0.5 x 0.3 cm red tissue bit.. Frozen seccion control. 7. "Right lingual nerve posterior margin' A 0.5 x 0.3 x 0.3 cm tan soft tissue fragment.. Frozen section contrcl. "Left lirgual nerve posterior margin" A 0.4 x 0.3 x 0.2 cm red-tan tissue Dit. Frozen section control. *Posterior margin left styloglcssus' A 0.8 x 0.5 x 0.3 cm red soft tissue bit. Frozen secticn control. 'Posterior margin left palatoglossus' A 0.8 x 0.3 x 0.3 cm red soft tissue bit. Frozen section control "Posterior margin midline tongue" A 1.0 x 0.6 x 0.5 cm, red-tan tissue bit. Frozen section control. "Left hypoglossus posterior margin' A 0.3 x 0.2 x 0.3 cm, red-tan bit. Frozen-section-contrel. 9. 'Right dorsal tongue posterior margin- A 0.7 x 0.4 x 0.3 cm red tissue bit. Frozen sectior control 10. 'Righe base of tongue osterior margin" A 1.4 x 0.3 x 0.3 cm red tissue bit. Frozen section control. 'Subtotal glossectomy." Received in formalin in a large container is a 10.6 x 6.7 x 4.3 cm, subtotal glossectony with bilaceral attached subnandibular glands. The attached soft tissue with submardibuiar gland measures 14 x 4 x i.5 cr. A portion of the right posterior base of tongue has been resected. The anterior floor of mouth and lateral gingiva are present. The left lateral tongue and lateral floor of mouth with extension to the anterior floor of routh is remarkable for an ulcerative, gray-tan tumor, 6.7 x 3.2 cm. It is 0.5 cm away from the posterior left base of tongue 1.3 cm from the lateral gingival mucosal margin ard 0.5 cm away from the left anterior floor of routh. Punctate henorrhages with pcssibie turor nodules extendirg from the lateral tumor are noted to have been previously incised. The inferior base margin of resection is inked green. The right iateral rargin of resection is inked blue. The left lateral resection is inked black. Anterior floor of mnouth yellow. Tumor has a naximum depth of 2.9 cm. It is 0.3 cm away from the surfacs is unremarkable. Hultiple lyrph nodes are identified ranging up to 1.5 cm. The left subnandibular gland is 5.5 x 2.2 x 2.3 cm. Multiple possibie lymph nodes are identified ranging up to 2.2 cn. 1lA. Anterior floor of mouth. with sublingual gland and tumor.. ilb. Turor of laterai tongue to lateral gingiva. 11C. Left inferiox base cf tongue with. tumor 1iD. Tunor to right lateral margin..
+
+--- Page 2 ---
+1le. Tumor to posterior left base of tongue. 11F. Turror to dorsal tongue. i1g. Right submandibular gland. 1IH. Multiple level I lynph nodes. l1I-J. Largest level I lymph node 11K. Left submandibular gland 11L. Multipie level I lymph nodes. 11M-N. One bisected left level I lymph node each.. 11o. Largest level I lymph node sectioned, left. Fhotographs have been taken. 12.  'Left neck level I.' Received in formalin in a smali container is a 4.6 x 4.1 x 3.2 cm irregular porticn of yellow fibroadipose tissue. Three possible lymph nodes are identified ranging up to 0.3 cm.. 12A. Level I lyrph ncde. 13. "Left neck level II. Received in formalin in a small container is a 5.5 x 4.2 x 1.3 cm, irregular portion of yeliow, fibroadipose tissue. Also possible lymph nodes are identified ranging up to 2.5 cm. The largest lymph node is remarkable for a gray-white possible porcion of turor. 13A. Multiple possible lymph nodes. 133-F. One bisected lymph node each 13G. Largest lymph ncde. 14. "Left neck level Iii.' Received in formalin in a small container is a 4.2 x 3.9 x 1.3 cm, irreguiar portion of fibroadipose tissue. Fibronuscular tissue is present. Multiple possible lyrph ncies are identified ranging up to 2.1 cm. The largest has a gray-white cut surface. 14A. Two possible lynphs. 14B-c. One bisected lymph node each 14D. Largest lymph ncde. 15. "Left neck level iv...  Received in fornalin in a small container is a 4.3 x 3.6 x i.3 cm, irregular portion of yellow fibrcadipose tissue. Multiple possible lymph nodes are identified ranging up to 1.3 cm. 15A. Multiple possible lymph nodes. 153-c. One bisected lyrph noda each FROZEN SECTION REPORT 1&2. Negative for carcinom. . Negative for carcinoma. -8. Negative for cancer. 9s10. Negative for carcinor M.D., have reviewed and interpreted tha frozen section Was requested. 1r M.D., have reviewed and interpreted the frozen section Permanent sectiors confirm frozen section report. HICROSCOPIC: SQUAXOUS LESIONS OF HEAD & NECK: RESECTION Site: Tongue Findings: Squanous celi carcinoma Differentiation: Moderate Gross: Ulcerative Size 6.7 cm (largest dimension)
+
+--- Page 3 ---
+Invasion: Present If present: depth 2.9 cm. Tumor border: Infiitrative Perineural invasion: Present If present:.Extensive Vascular invasion: Absent Bone/Cartilage invasion:  N/A Lyrphocyte infiltration: Absent Margins: Negative SQUAMOUS LESIONS OF HEAD & NECK: LYMFH NODE DISSECTIONS RIGHT LEVEL Extracapsular [or site] #Positive #Negative extension 0 7 N/A II 0 1 N/A TOTAL 8 N/A LEVEL Extracapsular (or site] #Positive #Negative extension 0 N/A IE 2 10 Present III 1 4 Absent IV 0 10 N/A TOTAL 3 31 Present
+
+--- Page 4 ---
+HICROSCOPIC DIAGNOSIS: 1. External jugular lymph ncde, right level II, resection: One lymph node, negative for carcinona.. 2-11. Tongue, subtotal glossectomy and separately submitted margins: Moderately-differentiated squamous cell carcinoma (6.7 cm) involving left tongue, invading to a depth ot 2.9 cm. Extensive perineural invasion identified. Hargins negative.  See TEMPLATE. Unremarkable submandibular glands. Fourteen lymph noies negative for carcinoma (0/l4). 12. Soft tissue of left neck, level I, dissection: Fibroadipose tissue, Megative for neoplasn. No lymphoid tissue present. 13. Soft tissue of left neck, level II, dissection: Metastatic squamous cell carcincma involving two of twelve lymph nodes (2/12) with extracapsular extension. 14. Soft tissue of left neck, level IIi, dissection: Hetastatic squamous cell carcinor.a involving one of five lyaph nodes {1/5}. 15. Soft tissue of left neck, level Iv, dissection: Ten lymph nodes negative for carcinona {0/10}. H.D., the signing staff pathologist, have persorally Iglose
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diff --git a/output/text/1e91b4f1-f90a-41f1-b0ab-0e8417a81a6c.txt b/output/text/1e91b4f1-f90a-41f1-b0ab-0e8417a81a6c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3b5fcd8dfea8742b106940a2479b9fc0ecec51a4
--- /dev/null
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+
+--- Page 1 ---
+1ed-0-3 Carcinoma, hobuler, NO5 8520|3 12||10 site Cobe: bresst Lowri ontev quadrert C50.5 TSS: Srtr: hrsot,Nos C50.9 cqcF SPECIMENS: A. SENTINEL NODES RIGHT AXILLA UUID:51601F8B-BA50-42C4-B0C9-B3581F80CD2C TCGA-E2-A15m-01A-PR Redacted  B. RIGHT BREAST NEEDLE LOCALIZATION SPECIMEN(S): A. SENTINEL NODES RIGHT AXILLA B. RIGHT BREAST NEEDLE LOCALIZATION GROSS DESCRIPTION: A. SENTINEL NODES RIGHT AXILLA  Received fresh are four tan pink lymph nodes ranging from 0.4cm to 2cm. Four touch preps are taken. A1: 1 lymph node A2: 1 lymph node A3: 1 lymph node A4: 1 lymph node B. RIGHT BREAST NEEDLE LOCALIZATION  Received fresh labeled with the patient's identification and "WLE right breast needle localization" is a previously  inked oriented 204g, 12.5 x 10 x 7.5cm needle localized lumpectomy with radiograph. Ink code: anterior-yellow, posterior-black, superior-blue, inferior-orange, medial-green, lateral-red. Specimen is serially sectioned from lateral to medial into 11 slices revealing 4 masses:.  Mass #1- 0.4cm, 1.3cm from the anterior margin in slice 5  Mass #2- 0.3cm, 1.5cm from mass #1 and 2.5cm from anterior margin in slice 5 Mass #3- 3.5 x 2.6 x 2cm, 0.5cm from the anterior and posterior margins in slice 6-9. Mass #4- 1cm, 2cm from mass #3 and 2cm from the deep margin in slice 6 A portion of the specimen is submitted for tissue procurement. Representatively submitted: B1: lateral margin slice 1 B2: slice 2 B3: biopsy site slice 2 B4: slice 2 B5-B9: slice 4  B10: mass #1 with anterior margin slice 5 B11: superior margin slice 5. B12: area in between mass #1 and mass #2 slice 5 B13: slice 5 B14: slice 5 B15: inferior margin slice 5. B16: deep margin slice 5 B17-B19: mass #3 slice 6 B20: mass #4 slice 6 B21: deep margin slice 6 B22-B25: mass #3 slice 7 B26-B27: mass #3 slice 8 B28-B30: mass #3 with clip ID in B28 slice 9 B31-B32: slice 10 B33-B34: medial margin slice 11 DIAGNOSIS: A. SENTINEL LYMPH NODES, RIGHT AXILLA, BIOPSY:E - ONE OF FOUR LYMPH NODES WITH ISOLATED TUMOR CELLS (O/4) NOTE: Cytokeratin AE1/3 stains were performed on A1 and A4 and is negative in A1 and positive in A4, highlighting scattered tumor cells. On the cytokeratin AE1/3 stain, ~ 100 cytokeratin positive cells are seen, a feature that would be consistent with isolated tumor cells versus a micrometastasis. The touch prep of A4 was reviewed and tumor cells were not seen. B. BREAST, RIGHT, NEEDLE LOCALIZATION WIDE LOCAL EXCISION: - INVASIVE LOBULAR CARCINOMA, SBR GRADE 2. - TUmOR MEASURES AT LEAST 3.5 CM. - TUMOR IS PRESENT AT THE ANTERIOR MARGIN.E - LOBULAR CARCINOMA IN SITU (LCIS) AND COLUMNAR CELL CHANGE.I - ONE  INTRAMAMMARY LYMPH NODE, NO TUMOR SEEN (0/1). - SKELETAL MUSCLE, NO TUMOR SEEN.
+
+--- Page 2 ---
+NOTE: Grossly, several iesions were noted that microscopically correspond to invasive carcinoma. The size of the. tumor is difficult to determine. While the single largest focus of tumor grossly is 3.5 cm, microscopically, invasive carcinoma is present in 6 of 11 slices of a 12.5 cm specimen and therefore may span ~ 6 cm. Clinical-radiologic correlation is recommended. A 0.5cm intramammary lymph node was also identified.. SYNOPTIC REPORT - BREAST Specimen Type: Excision Needle Localization. Yes Laterality: Right Invasive Tumor: Present Multifocality: Yes WHO CLASSIFICATION Invasive lobular carcinoma 8520/3 Tumor size: 3.5cm Tumor Site: 8:00 Margins: Involved at anterior Extent:: 0.1 cm Tubular Score: 3 Nuclear Grade: 2 Mitotic Score: 2 Modified Scarff Bloom Richardson Grade:. Necrosis: Absent Vascular/Lymphatic Invasion: None identified Lobular neoplasia: LCIS Lymph nodes: Sentinel lymph node Non-sentinel lymph node Lymph node status: Negative 0 / 5 isolated tumor cell clusters. DCIS not present ER/PR/HER2 Results ER: Positive PR: Positive HER2: Negative by IHC Performed on Case: Pathological staging (pTN): pT 2 N 0  Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition. CLINICAL HISTORY: Medial ? additional flap of tissue PRE-OPERATIVE DIAGNOSIS:E Right breast carcinoma INTRAOPERATIVF CONSI II TATION.  Right axilla: No tumor cells seen on four touch preps. Diagnosis called to Dr.. . Dr. ADDENDUM: ONCOTYPE DX BREAST CANCER ASSAY RESULTS: Recurrence Score: 29 CLINICAL EXPERIENCE: Patients with a recurrence score of:  29 in the clinical validation study had an average. rate of Distant Recurrence at 10 years of 19% 11 Positive ER Score: Pr Score: 7.1 Positive Her2 Score: 8 Negative Interpretation: ER Negative < 6.5 Positive >= 6.5 PR Negative < 5.5 Positive >= 5.5 Her2 Negative <10.7 Positive >=11.5 Equivocal = 10.7 - 11.4 See separate . report for further information.. Test performed at:
+
+--- Page 3 ---
+Gross Dictation: Final Review: Pathologist. Final: Pathologist Addendum: Pathoiogist Addendum Final: Pathologist.
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diff --git a/output/text/1e937c08-1106-4f5b-86a7-4ee494d38b02.txt b/output/text/1e937c08-1106-4f5b-86a7-4ee494d38b02.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e4e1f33e10f965e4216adec335bcbcae3a694075
--- /dev/null
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+
+--- Page 1 ---
+UUID:6E2365F3-0875-4949-8409-7E26BBCDE700 TCGA-AN-A0A3-01A-PR Redacted TSS Patient iD: Case #: DOB: Sex: Female Ethnicity (Race): Cancer Sample Diagnosis: Breast Cancer Histological description: Infiltrative ductal-lobular carcinoma Date of Procurement: Anatomic Site: Left Breast Tumor location: Primary Tissue Specification: Tumor Specimen Matrix: Tissue Specimen Format: OCT. Container: block Type of Procurement: surgery Grade: 2. T Stage: 3 N Stage:0 M Stage: 0 Treatment: none Treatment Details: n/a Norma! Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw. Matrix: Blood Specimen Format: frozen Container: tube Date of Procurement: Ics-0-3 sxrtiniomn, mflt^atng suchl svd 1ohule 8S3213 Sife: hrenst, Nos 050.9 h
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diff --git a/output/text/1e9b6b79-2f4d-4ed3-967e-b8a448baea44.txt b/output/text/1e9b6b79-2f4d-4ed3-967e-b8a448baea44.txt
new file mode 100644
index 0000000000000000000000000000000000000000..78254f45254e936059103f33fdafabac16af36c7
--- /dev/null
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+
+--- Page 1 ---
+tcD O-3 NOS ercensnas wrstheleol 8/20/3 Sample # C$C F Ste Arteriir wolly Gender: Male blodoler Cbn3 DOB: Race: White Mmrlapp Report Date: bladCs7 8 Pathology Report: yJ 7/22/1 3 Surgical Pathology Report UUID:74DA50BD-1762-42A2-84A3-637C8C1D435B Redacted FINAL PATHOLOGIC DIAGNOSIS A. Left pelvic lymph nodes; dissection:. - Eleven lymph nodes, no tumor (0/11). B. Distal left ureter; excision: - Ureter, positive for urothelial carcinoma in situ; no invasive carcinoma seen, see comment. C. Right pelvic lymph nodes; dissection: - Fourteen lymph nodes, no tumor (0/14). D. Urinary bladder, prostate, seminal vesicles and vas deferens; cystoprostatectomy: - Bladder with high grade urothelial carcinoma invading thru the muscularis propria and into the perivesical soft tissue, see pathologic parameters. - Prostatic urethra with urothelial carcinoma invading into the prostatic stroma. Urothelial Carcinoma Pathologic Parameters 1. Tumor type: Invasive urothelial carcinoma.. 2. Grade of tumor: High grade. 3. Depth of invasion: Extravesicular soft tissue. 4. Tumor distribution: Multifocal, 4.5 cm invasive carcinoma at right posterior, lateral and anterior wall; invasive carcinoma at prostatic urethra and prostate. 5. Ureteral margins: Left ureter, positive for in situ carcinoma; negative for invasive carcinoma; Right ureter, negative for tumor. 6. Distal urethral margin: Negative for tumor. 7. Soft tissue margin or serosa: Negative for tumor. 8. Lymph nodes: Negative for tumor (0/25). 9. pTNM: pT3a,N0,MX.
+
+--- Page 2 ---
+Effective January 1, 2010 this Checklist utilizes the 7th edition TNM staging system for Bladder of the American Joint Committee on Cancer (AJCC) and the. International Union Against Cancer (UICC). Comment On part B, there is pagetoid spread of urothelial carcinoma in situ involving the left ureter margin. Immunohistochemical stains performed on the distal left. ureter shows that the neoplastic urothelial cells are highlighted by CK20 and p53 (nuclear) positivity. CD44 highlights the background urothelium. This immunostaining pattern confirms the above diagnosis. Controls appropriate. Interpretation performed by the Attending Pathologist and reviewed with the Resident/Fellow, [] M.D. Electronically Signed Out by [], MD Clinical History: Patient is a  year-old male with bladder cancer undergoing cystectomy. Specimens Received: A: Left pelvic lymph nodes. B: Distal left ureter C: Right pelvic lymph nodes. D: Bladder, prostate, seminal vesicles, vas deferens. Gross Description: The specimens are received in four containers each labeled with the patient's name and medical record number. A. The first container is additionally identified as, "left pelvic lymph node". Received fresh and placed in formalin is a 4.5 x 4.0 x 1.5 cm aggregate of lobulated yellow fibrofatty tissue. The specimen is dissected for lymph nodes. to reveal multiple apparent lymph nodes ranging from 0.2-2.5 cm in greatest dimension. All apparent lymph nodes are submitted as follows: A1: 4 lymph node candidates. A2-3: 3 lymph node candidates in each cassette A4: One lymph node candidate, bisected. B. The second container is additionally identified as, "distal left ureter". Received fresh and placed in formalin is an unoriented, 0.7 cm long segment of ureter with small amount of adipose tissue attached. The specimen is sectioned and entirely submitted as B1.
+
+--- Page 3 ---
+C. The third container is additionally identified as, "right pelvic lymph nodes". Received fresh and placed in formalin is a 5.0 x 4.5 x 2.7 cm aggregate of lobulated yellow fibrofatty tissue. The specimen is dissected for lymph nodes to reveal multiple apparent lymph nodes ranging from 0.5-3.5 cm in. greatest dimension. All apparent lymph nodes are submitted as follows:. C1: 8 lymph node candidates C2: 4 lymph node candidates C3: 3 lymph node candidates C4: 2 lymph node candidates C5-6: One lymph node candidate, bisected in each cassette D. The fourth container is additionally identified as, "bladder, prostate, seminal vesicles vas deferens". Received fresh and placed in formalin is a 244.4 gram, 15 x 11 x 4.5 cm cystoprostatectomy specimen with attached mesenteric fat. The bladder measures 6.5 x 6 x 2.5 cm. The right ureteral stump measures 3.1 cm and the left 1.8 cm, and both demonstrate patent lumina. The prostate measures 4 x 2.8 x 2.7 cm. The right seminal vesicle measures 2.2 x 1.1 x 0.5 cm and the. right vas deferens 10 x 0.5 cm. The left seminal vesicle measures 2.8 x 1.3 x 0.6 cm and the left vas deferens 9 x 0.5 cm. The right half of the prostate and. bladder is inked blue and the left half is inked black. The prostate is opened anteriorly along the urethra and continued superiorly through the bladder in a Y-shaped incision. The prostate is serially sectioned from apex to base to reveal unremarkable parenchyma. The bladder demonstrates a 4.5 x 1.8 cm ulcerated area (lesion #1) involving the right posterior/lateral/anterior wall. Serial sectioning reveals tumor invasion into the muscularis propria to a depth of 0.8 cm, extending to 1.9 cm of the inked margin. There is another 1.4 x 0.7 cm ulcer in the left posterior/lateral wall (lesion #2). Serial sectioning reveals invasion into [] to a depth of [] cm, extending to [] cm of the inked margin. The remainder of the mucosa is tan-brown, edematous, and glistening with. a uniform 0.7 cm wall thickness. The bilateral ureteral orifices are identified and probe patent. Representative sections are submitted as follows: D1: Distal urethral margin D2: Left ureter margin D3: Right ureter margin. D4: Prostatic apical margin D5-7: Left side of prostate D8-10: Right side of prostate (prostate 60% submitted) D11: Seminal vesicles and vasa deferentia D12-13: Lesion #1, deepest invasion, tandem sections. D14: Lesion #1, deepest invasion, full thickness section D15: Lesion #1 D16-18: Lesion #2, entirely submitted D19: Uninvolved dome D20: Uninvolved anterior D21: Uninvolved trigone
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diff --git a/output/text/1eaf1fb5-fa16-4242-9e4b-66279d2d3df5.txt b/output/text/1eaf1fb5-fa16-4242-9e4b-66279d2d3df5.txt
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index 0000000000000000000000000000000000000000..d04fd3c3884b59dc58eb01ebd97481a573a99f07
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+--- Page 1 ---
+/cs-0-3 Cucinonu,infilrnHry,dutd,Nos 85otf3 S.tbsnst, Nos C5o.9 31fy page 1 / 2 Department of Cancer Pathology copy No. Date: Examination: Histopathological examination Internal invoice No.. Cost of diagnostic procedure Examination No.: Patient: xxx PESEL: XXX Age: Gender: F Material: 1. Multiple organ resection - right breast and axillary tissue Unit in charge: Physician in charge: Material collected on:. Material received on. Expected time of examination: up to 8 working days Clinical diagnosis: Cancer of the right breast. UUID:EF2DC6FB-F026-4025-B148-DF07194914AB0 TCGA-D8-A13I-01A-PR Redacted
+
+--- Page 2 ---
+Examination performed on. Macroscopic description: Right breast sized 35 x 23 x 9 cm removed along with axillary tissues sized 13 x 8 x 4 cm and a skin flap of 24 x 17 cm. Weight 1,400 g. Tumour sized 1.9 x 1.4 x 1.8 cm in the upper outer quadrant, 6 cm from the upper boundary, 2 cm from the  base and 1.8 cm from the front surface. Lymph nodes 2.4 cm in length. Microscopic description:d Carcinoma ductale invasivum - NHG1 (2 + 3 +1: 2 mitoses/ 10 HPF, visual area diameter 0.57 mm). Glandular tissue, outside the tumour, showing lesions of the type mastopathia fibrosa et cystica, hyperplasia ductalis simplex (ADH), adenosis sclerosans. AXILLARY LYMPH NODES: Metastases carcinomatosae in Iymphonodis (No It/xxI). Infiltratio capsulae lymphonodi et telae perinodalis. Emboliae carcinomatosae vasorum. Histopathological diagnosis: Carcinoma ductale invasivum mammae dextrae. Invasive ductal carcinoma of the left breast  Metastases carcinomatosae in lymphonodis axillae (No Il/xxil). Cancer metastases in axillary lymph nodes (No II/XXII) Invasivo carcinomatosa vasorum. Vascular invasion (NHG2, pT1c, pN1a). Compliance validated by: Results of immunohistochemical examination: Estrogen receptors found in 10-75% of neoplastic cell nuclei. Progesterone receptors found in over 75% of neoplastic cell nuclei. HER2 protein stained with HercepTestTM by DAKO. Negative reaction in invasive carcinoma cells ( Score = 1+ ) Compliance validated by:.
\ No newline at end of file
diff --git a/output/text/1efac890-eb98-4573-9e56-b36fbfd10613.txt b/output/text/1efac890-eb98-4573-9e56-b36fbfd10613.txt
new file mode 100644
index 0000000000000000000000000000000000000000..979a8bd887ad035627313ef4f894d63fbf872117
--- /dev/null
+++ b/output/text/1efac890-eb98-4573-9e56-b36fbfd10613.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:087A53B3-572F-4492-8D19-7CFE41C8DA39 TCGA-OR-A5LI-01A-PR Redacted Procedure: adrenalectomy and vena cava tumor Gross description: 17 x 12 x 20cm, 816g and 12cm vena cava tumor thrombus Diagnosis: adrenocortical carcinoma teD-o-3 Sarcinomo-, adrerul aor tical Reference Pathology: 8370|3 Diagnosis: adrenocortical carcinoma Site; Adrwral Bhnd Cortex C 74.D Weiss score: 6 J 2/s)3 Hough score: 4.52 Van Slooten score: 20.1
\ No newline at end of file
diff --git a/output/text/1f10350f-6165-444d-991d-9aa467f3450c.txt b/output/text/1f10350f-6165-444d-991d-9aa467f3450c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..687009249fd15865302bb2b81df6bccd330960d7
--- /dev/null
+++ b/output/text/1f10350f-6165-444d-991d-9aa467f3450c.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Other Related Data: Billing Type: Financial Number: Clinical Diagnosis & History: Left renal mass. Specimens Submitted: 1:SPLeft kidney and adrena 2: SP: Portion of left 11th ri 3: SP: Left para-aortic lymph node DIAGNOSIS: 1) KIDNEY, LEFT; RESECTION: -RENALCELL CARCINOMA CHROMOPHOBE CELL TYPE. -THE PATTERN OF GROWTH IS SOLID. -THE TUMOR GREATEST DIAMETER IS 15.8 CM.  THE TUMOR IS CONFINED WITHIN THE RENAL CAPSULE. - NO INVASION OF THE RENAL VEIN IS IDENTIFIED. -ALL SURGICAL MARGINS ARE FREE OF TUMOR. THE NON-NEOPLASTIC KIDNEY IS UNREMARKABLE. - NO ADRENAL GLAND IS IDENTIFIED. 2) RIB, PORTION LEFT ELEVENTH; BIOPSY: GROSSLY UNREMARKABLE. SECTIONS NOT YET READY BECAUSE OF NEED TO DECALCIFY. IF SIGNIFICANT MICROSCOPIC ABNORMALITIES ARE FOUND, AN ADDENDUM REPORT WILL BE ISSUED. 3) LYMPH NODE, LEFT PARA-AORTIC; BIOPSY: -BENIGN FIBROADIPOSE TISSUE. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Gross Descriptior 1) The specimen is received fresh,  labeled "Left Kidney and Adrenal". It consists of a kidney.  distorted by a cortical tumor. The non-neoplastic kidney measures 13.3 x 4.1 x 3.2 cm. The renal cortical tumor measures 15.8 x 13.8 x 6.2 cm. It has a uniform solid mahogany appearance on cut section with a central. Page 1 of 2
+
+--- Page 2 ---
+scar. The specimen is photographed and representative sections of the tumor are taken for Tps as well as cytogenetics and electron microscopy. The tumor is well-circumscribed attached to the kidney with a pseudocapsule. There is an attached ureter measuring roughly 9.3 cm in length by 0.3 cm in diameter with perinephric adipose tissue measuring 10.5 x 11.0 x 4.2 cm. No obvious palpable lymph nodes are present within this fat. There is no obvious adrenal gland is identified. Representative sections are submitted as per summary of sections. Summary of Sections: Fsc - Frozen Section Control UvM - Ureteral and Vascular Margins K - Non-neoplastic Kidney with Perinephric Fat. T - Tumor 2) The specimen is received fresh, labeled "Portion of Left 11th Rib. It consists of 7.5 x 1.0 x 0.7 cm portion of bone with attached soft tissue. No gross abnormalities are noted.. Representative sections are submitted following decalcification. Summary of Sections: RIB - rib 3) The specimen is received in formalin, labeled "Left Para- aortic Lymph Node". It consists of fragments of firm tan tissue in aggregate measuring 2.5 x 2.1 x 0.4 cm. It is entirely submitted. Summary of Sections: LN - Specimen in toto Histo Stain Results/Comments: Stain/Procedure Name Result Comment RECUT ADDITIONAL H&E Summary of Sections: Part Sect. SiteBlocks Pieces All 1 FSC 1 M N K 2 M T 7 M UVM 1 M 2 RIB 11 1 N 3 1n 1 M Y Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the. intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS: FAVOR ONCOCYTOMA. PERMANENT DIAGNOSIS: SEE FINAL DIAGNOSIS. Page 2 of 2 ENDOF REPORT
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diff --git a/output/text/1f289103-b571-4630-a8c0-a98c16eccf36.txt b/output/text/1f289103-b571-4630-a8c0-a98c16eccf36.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c3e2db7273f40437b5c482206c1b45a605b95a41
--- /dev/null
+++ b/output/text/1f289103-b571-4630-a8c0-a98c16eccf36.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Sample Number Sample Type  TUMOUR  Diagnosis  renal cell carcinoma, papillary type Year of Sample Collection Age at Sample Collection (yrs).  Days to Procedure Date  Days to Diagnosis Type of Procedure RESECT  Site of Tissue/Primary (Histology)  renal and ureter - kidney  Tumour Size (cm) 6  Histology  renal cell carcinoma, papillary type  Grade/Differentiation IV  Pathological T T1b  Pathological N NX Clinical M MO Histology Comments Sample Number Sample Type  BUFFY Year of Sample Collection  Age at Sample Collection (yrs).  Days to Procedure Date  Days to Diagnosis  UUID: 3198202A-AFF1-4ABD-B0AD-B568341A1E9E TcDs-3 TCGA-HE-A5NK-01A-PR Redacted Site; Kidney N6s~C64.9 nO x[n/3 W H7\13 Criteria crepancy HPAAD Dual,
\ No newline at end of file
diff --git a/output/text/1f51fe3e-7f5c-4850-9ec2-24f3bc95fc8b.txt b/output/text/1f51fe3e-7f5c-4850-9ec2-24f3bc95fc8b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..73cb300a45a4036385320e63853968b933a3223d
--- /dev/null
+++ b/output/text/1f51fe3e-7f5c-4850-9ec2-24f3bc95fc8b.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+14b-0-3 infitratiny Suct t4vcinom,,sd gSor| 3 Sihe: brunot, Nos c 5o q page 1 / 1 Department of Cancer Pathology copy No. Date: Examination: Histopathological examination Examination No.: Patient:  PESEL: Age: Gender: F Material: Multiple organ resection - left breast with sxil?r : tis-Jes. Unit in charge: Physician in charge: Material collected on: Material received on. Expected time of examination: up to Clinical diagnosis: Cancer of the ieft oreast.  Examination performed on: .  Results of immunohistochemical examination: Estrogen receptors found in 75% of neoplastic cell nuclei. Progesterone receptors found in 10% of neoplastic cell nuclei. HER2 protein stained with HercepTestTM by DAKO. Positive reaction in invasive cancerous cells ( Score = 3+ ) ance validated by:  Examination performed on Macroscopic description: Left breast, sized 22 x 17 x 5cm, removed along with axillary tissues sized 9 x 6 x 2 cm and a skin flap of 23 x 11 cm. Tumour sized 3.1 x 1.5 x 1.7 cm in the upper outer quadrant, placed 6 cm from the upper edge, 0.7 cm from the base and 1.2 cm from the skin.. Microscopic description:e Carcinoma ductale invasivum - NHG3 (2+3+3/21 mitoses/10 HPF - visual area: 0.55mm). Glandular tissue outside the tumour showing lesions of the type mastopathia fibrosa et cystica, hyperplasia  ductalis simplex (UDH). Axillary lymph nodes: Metastases carcinomatosae in lymphonodo (No 1/xV).  Infiltratio capsulae lymphonodi. Histopathological diagnosis: Carcinoma ductale invasivum mammae sinistrae.  Metastases carcinomatosae in lymphonodo axillae (No I/XV). (NHG3; pT2; pN1a). RUCTAL rNVAEvE cARc^NA NE A8tT7C UUID:078476E6-799F-4DED-A219-CBFE2DE3C778 TCGA-D8-A140-01A-PR Redacted
\ No newline at end of file
diff --git a/output/text/1f5df5a8-4bca-469b-b41c-4687dcbe22f5.txt b/output/text/1f5df5a8-4bca-469b-b41c-4687dcbe22f5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..687c949636b886e640a4e24212994d8cc5f39fbc
--- /dev/null
+++ b/output/text/1f5df5a8-4bca-469b-b41c-4687dcbe22f5.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+1cs-s-3 Site: bunt, Nos C 50.9 3/n1n page 1 / 1 Department of Cancer Pathology copy No. Date: Examination: Histopathological examination Internal invoice No. Cost of diagnostic procedure Examination No.: Patient: xxx PESEL: XXX Age: Gender: F Material: Multiple organ resection -- right breast Unit in charge:  Physician in charge: Material collected on: Material received on: Expected time of examination: up to 8 working days Clinical diagnosis: Right breast with tumour and right axillary Jymphnodes Examination performed on: Macroscopic description: Right breast sized 21.4 x 16.5 x 5.4 cm removed along with axillary tissues sized 7 x 9 x 3 cm. Weight 920 g. Lesion sized 3 x 3.3 x 2.1 cm on the boundary of outer quadrants, 3 cm away from the lower boundary, 0.5 cm from the base and 2.9 cm from the skin. Microscopic description: Carcinoma ductale invasivum - NHG3 (3 + 3 +2: 26 mitoses/10 HPF, visual area diameter 0.55 mm).  Invasio carcinomatosa vasorum massiva. Reactio lymphocytaria peritumoralis. Mamilla sine laesionibus. Glandular tissue showing parenchyma atrophy. Axillary lymph nodes: Metastases carcinomatosae in Jymphonodis (No III/xI). Histopathological diagnosis: Carcinoma ductale invasivum mammae dextrae. Invasive ductal carcinoma of the left breast Metastases carcinomatosae in lymphonodis axillae (No Il/xi). Cancer metastases in axillary lymph nodes (No I1/xI) (NHG3, pT2, pN1a). Compliance validated by: Examination performed on:  UUID:947954F1-4CBA-42D3-99B2-6BE6E44E5239 TCGA-D8-A1JM-01A-PR Redacted
+
+--- Page 2 ---
+Results of immunohistochemical examination: Estrogen receptors found in less than 10% of neoplastic cell nuclei. No progesterone receptors found in neoplastic cell nuclei. HER2 protein stained with HercepTestTM by DAKO. Negative reaction in invasive cancerous cells ( Score = 1+ ) Compliance validated by: :
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diff --git a/output/text/1f62935d-4794-418a-9de1-74c809222cdb.txt b/output/text/1f62935d-4794-418a-9de1-74c809222cdb.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4490efef54d1d0b064d368afdc6416c97912a0ec
--- /dev/null
+++ b/output/text/1f62935d-4794-418a-9de1-74c809222cdb.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TCGA #:  Internal Sample ID Diagnosis: This involves an invasive, poorly differentiated colon adenocarcinoma (G 3; partially mucinous carcinoma) with penetration of all parietal layers (p T 3), as well as free lymph nodes and free resection margins. Jc5-03 adenocarcinoma N0s81yd/3 Site: Cvcum (pw cacF) C18.0 3/30f Redacted UUID:132876AD-5B42-4315-B96D-8D4D6BB1F33C
\ No newline at end of file
diff --git a/output/text/1f7c3b39-83dc-482c-972d-d30c7790f9b1.txt b/output/text/1f7c3b39-83dc-482c-972d-d30c7790f9b1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5b34974d3edc94c99886cfaa68ad2c49f02b4303
--- /dev/null
+++ b/output/text/1f7c3b39-83dc-482c-972d-d30c7790f9b1.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+Clinical Diagnosis & History: Patient with right breast mass, suspicious MMg, FNA positive adenocarcinoma. Specimens Submitted: 1: sp: Sontinel node #1. level 1, right axilla 2: SP Sentinel node #2, level 2. right axilla 3: SP: Sentinel nodo #3. level 2. right axilla 4 SP: Right breast cancer : 5: Sp: Posterior margin. rigat breast 6: Sp: Anterior medial margin, right breast 7: sp: Non-sentinel tissue, right axilla  DIAGNOSIS: 1) SENTINEL LYMPH NODE #1, LEVEL I, RIGHT AXILLA; BIOPSY: THREE BENIGN LYMPH NODES (O/3). - DEEPER LEVEL RECUTS AND SPECIAL STAINS (AE1:AE3 AND CAM S.2) ARE ALSO NEGATIVE FOR METASTASIS. 2) SENTINEL LYMPH NODE #2, LEVEL II, RIGHT AXILLA; BIOPSY:S TWO BENIGN LYMPH NODES (0/2). - DEEPER LEVEL RECUTS AND SPECIAL STAINS (AEI:AE3 AND CAM S.2) ARE ALSO  NEGATIVE FOR METASTASIS. 3) SENTINEL LYMPH NODE #3, LEVEL II, RIGHT AXILLA; BIOPSY:S  ONE SENIGN LYMPH NODE (O/1). - DEEPER LEVEL RECUTS AND SPECIAL STAINS (AEI:AE3 AND CAM 5.2) ARE ALSO NEGATIVE FOR METASTASIS. 4) BREAST, RIGHT; EXCISION: . INVASIVE DUCTAL CARCINOMA, NOS TYPE, HISTOLOGIC GRADE III/IIA (SLIGHT OR NO TUBULE FORMATION), NUCLEAR GRADE III/III (MARKED VARIATION IN SIZE AND SHAPE). MEASURING 4.O CM IN LARGEST DIMENSION GROSSLY. - NO DUCTAL CARCINOMA IN SITU (DCIS) IS IDENTIFIED. - NO CALCIFICATIONS ARE IDENTIFIED IN THE INVASIVE CARCINOMA.S - NO VASCULAR INVASION IS NOTED. - NO INVOLVEMENT OP THE SURGICAL MARGINS BY INVASIVE CARCINOMA IS IDENTIFIED. THE NON-NEOPLASTIC BREAST TISSUE IS UNREMARKABLE.S - THE TUMOR IS NEGATIVE FOR ER, PR, AND HER2-NEU (STAINING INTENSITY OF O). PATH REPORT + Continued on next page ** 1es-0-3 Circnoma mfi1fntirj duct, nvs 9svu/3 Site. brnst, Nos C50.9 lu 10ja>/u UUID:03526CFD-0C3E-4ACB-AB26-3E0B0ED0ADA2 TCGA-AO-A128-01A-PR Redacted
+
+--- Page 2 ---
+Page 2 of 5 BREAST, RIGHT, POSTERIOR MARGIN; EXCISION: 5 - FIBROADIPOSE TISSUE. - NO TOMOR SEEN. BREAST, RIGHT, ANTERIOR MEDIAL MARGIN; EXCISION:S FIBROCySTIC CHAnGES.  SCLEROSING ADenOSIS. FLORID DUCTAL HYPERPLASIA. - MICROCALCIFICATIONS IN BENIGN DUCTS. 7) NON-SENTINEL LYMPH NODE, RIGHT AXILLA; BIOPSY: - NINE BENIGN LYMPH NODES (O/9). I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL). AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. **. Report Electronically Signed Out **. Special Studies: Result Special Stain AE1:AE3 cam 5.2 IMM RECUT NEG CONT AE1:AE3 CAM 5.2 IMM RECUT NEG CONT A31:AE3 CAM 5.2 IMM RECUT NEG CONT ER-C PR-C HER2-C AE1:AE3 CAM 5.2 S-100 HMB-45 A103 CD30 BERH2 CD45 (LCA) ALK Berep4 IMM RECUT NEG CONT NEG-HER2 P53 IMM RECUT NEG CONT PATH REPORT Continued on next page.
+
+--- Page 3 ---
+3 Description 1) The specimen is received fresh for frozen section diagnosis. labeled. "Sentirel node #I, level 1, right axilla". It consists of one lymph node, measuring 2.0 x 0.4 x 0.2 cm. "It was bisected and entirely submitted. Summary of Sectioas: FSC frozen section control 2) The specimen is received fresh for frozen section diagnosis, labeled, "Sentincl node #2. level 2, right axilla". It consists o one lymph rode, measuring 1.0 x 0.3 x 0.2 cm. The lyaph node is bisected and entirely submitted for frosen evaluation. Surmary of Sections: FSC  frozen section control 3} The specimen is reccived fresh for frosen section diagnosis. labeled, "Sentinel node #3, lovel 2, right axilla". It consists of one lymph node, measuring 0.8  0.2 x 0.2 cm. Tho lymph node is bisected and entirely submitted for frosen evaluation. Sunmary of Sections: FSC frozea section control 4) Tho specimen is received fresh for froren section diagnosis, labeled, "Right breast cancer, (long stitch lateral and short superior)".** consists of a segment of soft yellow fatty tissue, measuring 12.0 x 12.5 x It 4.5 cn. A long and short stitch are identified designating the superior and lateral margins. The specimen is inked as follows: posterior-black, anterior-yellow, suporior-bluc, and inferior-red. The specimen is serially sectioned and a cut-surface revealed a well-circumscribed soft tan to yellow tumor mass, measuring 4.0 x 2.5 x 2.5 cm.. This is located 1.5 cm from the.  anterior margin and 1.0 cm from the posterior margin, 2.5 cm from the superior  margin and 2.0 cm from the inferior margin, s.0 cm from thc medial margin and 2.0 cm from the lateral margin. The ramaining breast is soft yellow fatty tissue with irregular fibrosis. .No other separate lesion is identified. Representative tissue is submitted for frozen evaluation and representative sections are submitted. Suamary of Sections: Fsc frozen section control LM lateral margin MM medial margin AM anterior margin PM posterior margin SM superior margin IM inforior margin PATH REPORT Continued on next page **
+
+--- Page 4 ---
+4 tumor mass with surrounding  representative sections of the breast tissue The specimen is received fresh. labeled, "posterior margin. sight breast, (stitch marks new margin to ink)". It consists of one segment of soft yellow fatty tissue, measuring 10.0 x 2.2 x 0.8 cm. A black suture is noted on one side of the specimon, which is inked black. serially sectioned and cut-surfaces revealed a soft yellow to tan tissue.  The specimen is No tumor is identified. The entire specimen is submitted. Summary of Sections: U - undesignated 6) The specimen is received fresh. labeled, rAnteriox medial margin, right breast, (stitch marks new margin to ink)". It consists of one segment of soft yellow to tan tissue, measuring 3.0 x 3.0 x 2.0 cm. Multiple cysts containing dark-colored fluid is identified. The suture site of the specimen is inked black. The specinen is serially sectioned. revealed a soft tan to yellow tissue with multipie cysts. No firm mass is A cut-surface identified. The entire specimen is submitted. Summary of Sections: U - undesignated 7) The specimen is received in formalin, labeled, "Non-sentinel tissue, right axilla". It consists of multiple pieces of irregular tan to yellow fatty tissue. The aggregate measured 4.5 x 3.0 x 0.8 cm. Dissection revealed multiple soft tan lyuph node with a sizes ranging from 0.3 to 0.9 The entire lymphoid tissue is submitted. Summary of Sections: U undesignated Summary of Sections: Part 1:  SP: Sentirel node #1, level 1, right axilla Block Sect. Site pCs 1 Fsc 2 Part 2: Sentinel node #2, level 2, right axilla Block Sect. Site PCs 7 FsC 2 PATH REPORT Contirued on noxt page
+
+--- Page 5 ---
+Part 3: SP: Sentinel node #3.. right axilla Block Sect. Site  PCs 1 esc 2 Part 4: SP: Right breast carcer Block Sect. site AM PCs 1 7sc IM 1 LM H 1 1 MM 17 1 Py 1 1 1 r Paxt 5: SP: Posterior margin, right breast Block Sect. Site PCs 6 U 10 Part 6: SP: Anterior medial margin, right breast Block Sect. Site PCs 7 Paxt 7: SP: Non-sentinel tissue, right axilla : Block Sect. Site PCs U 10 Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the consultation. 1) FROZEN SECTION DIAGNOSIS: BENIGN. PERMANENT DIAGNOSIS:  SamE . 2) FROZEN SECTION DIAGNOSIS: BENIGN. PERMANENT DIAGNOSIS:  SAME. 3) FROZEN SECTION DIAGNOSIS: BENIGN.  PERMANENT DIAGNOSIS:  SAME. 4) FROZEN SECTION DIAGNOSIS: INVASIVE CARCINOMA. PERMANENT DIAGNOSIS: SAME. PATH ** End of Report ** REPORT
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diff --git a/output/text/1f7d0bee-36c2-4092-9099-645f392a1b27.txt b/output/text/1f7d0bee-36c2-4092-9099-645f392a1b27.txt
new file mode 100644
index 0000000000000000000000000000000000000000..11ab12a747ee1a11d6b398b25a0da3138f141a42
--- /dev/null
+++ b/output/text/1f7d0bee-36c2-4092-9099-645f392a1b27.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+UUID: 5D79D370-F174-4CCB-AF64-5617EBF352BE0 Supplementary Report. TCGA-ZS-A9CF-02A-PR Redacted Nature of Specimen(s). 1. Left lobe liver 2. Portal lymph node - 1. MALE clinical Information Supplied Left hepatectomy today. Past medical history of primary hepatocellular carcinoma segment 5&6 resected . Haemochromatosis. lesion ... FROCREMENt J/E: Macro Report 1. Received is a left lobe of liver measuring 132x95x58mm. The surgical resection margin is inked blue. On transverse slicing J 2 distinct tumour nodules each with a hard or cream-white cut surface are noted. Focal areas of necrosis and softening are present. The larger lesion measures 72x59x45mm and the smaller 60x35x44mm. The larger lesion is 4mm from the inked blue resection margin. The smaller lesion is clear by approximately 26mm. An area of firm white scarring is present at the resection margin. This is especially clear near the larger lesion. 2. A fragment of brown-white tissue 2lx8x8mm. On transverse slicing a lymph node is revealed. Micro Report. 1. Sections confirm two tumours with morphological features consistent with hepatocellular carcinoma. Both tumours show an anastomosing trabecular architecture with large atypical cells bearing abundant cytoplasm and focally producing bile. The larger lesion is associated with spread into small branches of portal veins. Although the lesion approaches close to the inked resection margin the final resection margin is entirely clear of tumour. The smaller of the 2 lesions, as noted macroscopically, is well clear of the resection margin. Adjacent liver parenchyma shows some chronic inflammation in portal areas and steatosis. Both are mild in degree. There is no obvious evidence of iron pigment on routine staining however liver histochemistry will be performed and results issued in a supplementary report. Page 1 of 4 IcDo 3 Corensn, fupatoelleler NoS, ACKNOWLEDGEMENT OF RECEIPT 9/70/3 WARD SECRETARY DOCTOR Sute:sLiisr CQQ.U J 5/9/14
+
+--- Page 2 ---
+Date Recvd wdLe lssucu Supplementary Report Conclusion Two nodules of hepatocellular carcinoma. Both completely excised. 2. Sections show a reactive lymph node with numerous oleogranuloma. There is no evidence of malignancy. Signature of Pathologist(s) Page 2 of 4 ACKNOWLEDGEMENT OF RECEIPT WARD SECRETARY DOCTOR
+
+--- Page 3 ---
+Date Recvd vace lssueu Supplementary Report Results of histochemical stains of normal liver. No evidence of excess iron. No evidence of fibrosis, cirrhosis or collapse. No evidence of Orcein positive granules. No evidence of pAs positive. diastase resistant globules.. Signature of Pathologist(s). Page 3 of 4 ACKNOWLEDGEMENT OF RECEIPT WARD SECRETARY DOCTOR
+
+--- Page 4 ---
+Date Recvd Date Issued. Supplementary Report Tumour cells show canalicular staining pattern with polyclonal CEA. and focally cDi0. There is weak expression of HepRl. The findings are in keeping with hepatocellular carcinoma.. Signature of Pathologist(s). Page 4 of 4. ACKNOWLEDGEMENT OF RECEIPT WARD SECRETARY DOCTOR Retuvrence pri`mrny a{so received 27/14 HCC QUALIFIE
\ No newline at end of file
diff --git a/output/text/1fc40d17-2dc0-4dc1-a813-5006f39a2c9d.txt b/output/text/1fc40d17-2dc0-4dc1-a813-5006f39a2c9d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..26d8eefcd612585ef091fcbe3a342dc3b0a67464
--- /dev/null
+++ b/output/text/1fc40d17-2dc0-4dc1-a813-5006f39a2c9d.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+il Surgicai Pathology Report Name: Case #: DOB: Collected: Gender: Received: MRN: Reported: Location: Copy To: :: Physiclan: Pathologic Interpretation: LEfT BREAST SENTIneL nODE # 1 (COUNt A. : One lymph node negative for carcinoma (0/1). (see note). 1cs-0-3 Cauinomn. iifilnat!Ng 1obululw, nos 852013 B.  Right Breast Sentinel nODe # 1, (Count - One lymph node negative for carcinoma (0/1). (see note).. Sife: breat Nos C50.9 C.  RIght BREaSt SEntIneL nODe # 2, (COuNt One lymph node negative for carcinoma (0/1). (see note). UUID:D92CABBE-8D7E-41ES-B702-9ED07E94E5C4 TCGA-EW-A155-01A-PR Redacted  RIGhT BREAST SENTINEL nODE # 3, (COUNT - One lymph node negative for carcinoma (0/1). (see note). E. RIGht BREASt SENTINEL nODE # 4, (COUnt - One lymph node negative for carcinoma (0/1). (see note). Left Breast mastectomy: - INVASIVE LOBULAR CARCINOMA, moderately differentiated (see note). ' Invasive carcinoma is present at least 0.3 cm from the nearest resection margin (slide F3). - Invasive carcinoma extensively involves the nipple and dermis. - No in situ carcinoma is identified. - No definitive lymphovascular invasion is seen. - Microcalcifications are present and associated with normal breast parenchyma.. - AJCC staging. PT3 NO (sh) Mx. Please see tumor summary. Note: The invasive carcinoma measures 4.5 cm by gross measurement. However, based on adjacent sections in sides. F9 through F12 the microscopic measurement of tumor size is estimated as at least 6.1 cm. Receptor studies were. reported previously 7 I. Keratin stains on the lymph nodes will be reported in an addendum. Right breast mAstectomy: G. - INVASIVE DUCTAL CARCiNOMA, moderately differentiated, Nottingham grade 2 (3+3+1). measuring at least 1.1 cm in greatest dimension (slide G15). Two additional invasive foci each measuring 0.4 cm are found in slides G12 and G17. - No lymphovascular invasion is seen. - DUCTAL. CARC!NOMA IN SITU, high nuclear grade, solid on cribriform type, with central comedo necrosis and. calcifications is present in 10 of 17 blocks (EiC positive). located more than 1.0 cm from nearest margin.. - AJCC staging PT1c NO(sh) Mx. See tumor summary. Note: Hormone receptor studies and keratin stains on the lymph nodes will be reported in an addendum.. H.  LEFT BREAST ADDITIOnAL SUPERIOR SKIN: - Skin and benign breast parenchyma.. LEft BreaSt ADDITIONal meDIal SKIn: . - Skin and benign breast parenchyma. TUMOR SUMMARY invasive CarcinomA Of the breast (LeFT): Specimen: Total breast (including nipple and skin). Procedure: Total mastectomy (including nipple and skin) Lymph Node Sampling: Sentinel lymph node(s) Specimen Integrity: Multiple designated specimens (eg, main excision and identified margins) Specimen Laterallty: Left Tumor Focality: Single focus of invasive carcinoma
+
+--- Page 2 ---
+SURGICAL PATHOL Report Macroscopic and Microscopic Extent of Tumor. Skin: Invasive carcinoma directly invades into the dermis or epidermis without skin ulceration. Histologlc Type of Invasive Carcinoma: JNVASiVE LOBULAR CARC!NOMA Histologic Grade: Nottingham Histologic Score/Overall Grade= 2 (scores of 6 or 7). Margins: Margins uninvolved by invasive carcinoma Lymph-Vascular Invaslon: Not identified Dermal Lymph-Vascular Invaslon: Not identified Lymph Nodes (required only if lymph nodes are present in the speclmen). Number of sentinel lymph nodes examined: 1 Total number of lymph nodes examined (sentinei and nonsentinei): 1. Number of lymph nodes with macrometastases (>0.2 cm): 0 Number of lymph nodes with micrometastases (>0.2 mm to 0.2 cm and/or >200 cells):0  Number of lymph nodes with isolated tumor. cells (s0.2 mm and s200 cells): 0 Pathologic Staging (based on information available to the pathologlst) (pTNm) (Note M) pT3: Tumor >50 mm in greatest dimension. Reglonal Lymph Nodes (pN)d Category (pN) pNO: No reglonal lymph node metastasis identified histologlcally Note: tsolated tumor cell (ITC) clusters are defined as small clusters of cells not greater than 0.2 mm or single tumor cells, or a cluster of fewer than 200 cells in a singie histologic cross-section.*iTCs may be detected by routine histology or by immunohistochemical (IHC) methods. Nodes contalning onty ITCs are exciuded from the tota! positive node count tor purposes of N classification but shouid be included in the total number of. nodes evaluated. Modifier (sn): Only sentinel node(s) evaluated. if 6 or more sentinel nodes and/or nonsentinel nodes are removed, this modifier should not be used. Distant Metastasis (M) : Not applicable Ancillary Studles Estrogen Recaptor Performed on another specimen: . Results: Immunoreactive tumor ceils present (1%) Progestorone Receptor Performed on another specimen: Results: Immunoreactive tumor cells present (1%) HER2 Immunoreroxidas. Studies Performed on another specimen: Results: Negative (Score 0) Microcalclficatons: Present in non-neoplastic tissue. INVASIVE CARCINOMA OF THE BREAST (RIGHT): Specimen : Total breast (including nipple and skin) Procedure : Tota! mastectomy (including nipple and skin) Lymph Node Sampling: Sentinel lymph node(s) Specimen Integrity: Single intact specimen (margins can be evaluated). Specimen Laterality: Right Tumor Focality: Multiple foci of invasive carcinoma Number of foci: 3 Sizes of indlvidual foci: 1.1 cm. 0.4 cm, 0.4 cm  Page 2 of 6
+
+--- Page 3 ---
+SURGICAL PATHOL Report  Macroscopic and Microscopic Extent of Tumor Skin: Invasive carcinoma does not invade into the dermis or epidermis Nipple: DCIS does not involve the nipple epidermis Skeletal muscle: No skeletal muscle present Ductal carcinoma In situ (DCis): DCIS is present, EIC positive Size of (Extent) of DCIS Number of blocks with DCiS: 10 Number of blocks examined: 17 Architectural Patterns: Comedo, Cribriform, Solid Nuclear Grade: Grade ill (high) Necrosls: Present, central (expansive "comedo" necrosis). Lobular Carcinoma In Situ (LCis): Not identified Histologic Type of Invasive Carcinoma: INVASIVE DUCTAL CARCINOMA (no speciai type or otherwise specified) Histologic Grade: Nottingham Histologic Score. Tubules: Score 3: <10% of tumor area forming glandular/tubular structures Nuclear Pleomorphism: Score 3: Vesicular nuclei, often with prominent nucleoli, exhibiting marked variation in size and shape. occasionally with very large and bizarre forms Mitotic Count: Score 1 Overall Grade: Grade 2 (scores of 6 or 7) Margins : Margins uninvolved by invasive carcinoma and DCIS Treatment Effect: Response to Presurgical (Neoadjuvant) Therapy: No known presurgical therapy Lymph-Vascular invasion: Not identified Dermal Lymph-Vascular Invasion:: Not identified Lymph Nodes (required only If lymph nodes are present in the specimen) Number of sentinel lymph nodes examined: 4. Total number of lymph nodes examined (sentinel and nonsentinel): 4 Number of lymph nodes with macrometastases (>0.2 cm): 0 Number of lymph nodes with micrometastases (>0.2 mm to 0.2 cm and/or >200 cells):0 Number of lymph nodes with isolated tumor cells (s0.2 mm and s200 cells): 0 Extranodal Extenslon: Not identified Method of Evaluation of Sentinel Lymph Nodes: Hematoxylin and eosin (H&E), one level and Immunohistochemistry. Pathologic Staging (based on information available to the pathologist) (pTNm) (Note M) pT1c: Tumor >10 mm but<20mm in greatest dimension Regional Lymph Nodes (pN) Category (pN) pN0: No regional lymph node metastasis identified histologically. Note: Isolated tumor cell (rTC) clusters are defined as small clusters of cells not greater than 0.2 mm or single. tumor cells, or a cluster of fewer than 200 cells in a single histologic cross-section.* iTCs may be detected by. routine histology or by immunohistochemical (IHC) methods. Nodes containing onty tTCs are excluded from the totai positive node count for purposes of N classification but should be included in the total number of. nodes evaluated. Modifier (sn): Only sentinel node(s) evaluated. If 6 or more sentinel nodes and/or nonsentinel nodes are removed, this. modifier should not be used. Distant Metastasis (M): Not applicable Ancillary Studles Estrogen Receptor: Pending Progesterone Receptor : Pending HER2 Immunoperoxidase Studies: Pending Microcalclfications:d - Present in DCIS NOTE: Soms immunohistochamical antibodies ore anolyte spec(fic reagens (ASRs) validoted b y.ThaeASs tre cltnically uaeful indicators shat do not regutre FDA approval. Thee clonss ors used. IDS=ER, PgR 636-PR, A4&5-H&R2, H-I!=EGFR. AUl imm ssochemkal stains are used with formalin or moiecular fixed. parafin embedded tissxs. Derection is by Exvision Method. The results are read by e. st es posive or negtive As the attending pathologist, I attest that I: (i) Examined the relevant preparation(s) for the specimen(s): and (ii) Rendered the diagnosis(es). Page 3 of 6
+
+--- Page 4 ---
+SURGICAL PATHOL Report ***Electronically Signed Out By*** Procedures/Addenda Addendum Date Ordered:d Status: Signed Outd Date Complete:d Date Reported: Addendum Diagnosis A. Loft Breast Sentinel Lymph Node # 1 (count - Negative for keratin staining cells. B. Right Breast Sentinel Lymph Node # 1 (count : - Negative for keratin staining cells. c. Right Breast Sentinel Lymph Node # 2, (count - Negative for keratin staining cells. D. Right Breast sentinel node # 3, (count - Negative for keratin staining cells. E. Right Breast sentinel node # 4, (count : - Negative for keratin staining cells. G. Right Breast Mastectomy:d - The tumor cells are positive for ER and HER2/Neu (3+) and negative for PR. Intraoperative Consultationd A. Sentinel node #1 count on left breast, FS: Lymph node, no carcinoma seen. B. Right breast sentinel node # 2, count , FS: Negative for carcinoma.. C. Right breast sentinel node # 3, count . FS: Negative for carcinoma. D. Right breast sentinel node # 3, count FS: Negative for carcinoma. E. Right breast sentinel node # 4, count FS: Negative for carcinoma. Clinical History:. Left breast biopsy -- invasive lobular carcinoma with direct skin involvement 4.5 cm mass left breast anterior depth central to nipple, 4.5 cm biopsy marking clip in upper outer quadrant (calcification) and one in posterior depth in superior lateral quadrant. Operatlon Performed Bilateral mastectomy with sentinel node biopsy, possible axillary Pre Operative Dlagnosis:  None Provided Page 4 of 6
+
+--- Page 5 ---
+SURGiCAL PATHOL Report Specimen(s) Received:  on left breast, FS A: Sentinel node # 1 count FS B: Right breast sentinel node # 2, count i. FS C: Right breast sentinel node # 3, count FS D: Right breast sentinel node # 3. count ,FS E: Right breast sentinel node # 4, count . F: Left breast G: Right breast H: Additional superior skin left breast I: Left breast additional medial skin Gross Description: A. Received in formalin are four separate tissues. Submitted for frozen section. The first is one fragment of rubbery, brown-tan tissue that measures 1.5 x 1.0 x 0.3 cm. Submitted in toto in cassette A1fs. The second is one fragment of brown-tan rubbery tissue, measuring 2.0 x 1.1 x 0.3 cm. Submitted in toto cassette A2FS. The third is one fragment of rubbery brown-tan tissue that measures 1.8 x 1.5 x 0.3 cm. Submitted in toto in cassette A3FS. The fourth is one fragment of rubbery brown-tan tissue that measures 2.2 x 1.5 x 0.3 cm. Submitted in toto in cassette A4FS. B. Received in formalin are two fragments of rubbery brown-tan tissue that measures 2.5 x 2.0 x 0.3 cm in aggregate. Submitted in toto in cassette B1FS. c. Received in formalin is one fragment of rubbery brown-tan tissue that measures 2.9 x 2.9 x 0.3 cm. The tissue is submitted in toto in cassette C1FS. D. Received in formalin is one fragment of brown-tan tissue that measures 2.2 x 0.6 x 0.3 cm. Submitted in toto in cassette D1FS. E. Received in formalin is one fragment of tan-yellow tissue, measuring 2.5 x 1.4 x 0.3 cm. Submitted in toto in cassette E1fs. F. Received in formalin is a 420 gram left partial mastectomy specimen (17.5 x 15.0 x 5.5 cm) with a white-tan skin ellipse (12.2 x 7.0 cm). The nipple measures 1.5 cm in diameter, the areola measures 3.5 cm in diameter. The specimen resection margins have previously being inked black. The specimen has been previously cut. There is a 4.5 x 3.5 x 2.5 cm irregular firm, grey-tan poorly circumscribed mass located centrally in the specimen posterior to the nipple. This mass lies within 4.0 cm of the deep resection margin, 0.8 cm of the superior resection margin, 5.5 cm of the lateral resection margin, 2.0 cm of the medial resection margin and 2.0 cm from the inferior resection margin. This mass appears to grossly invade the nipple and skin. The mass also appears to contain minute amounts of hemorrhage and necrosis. There is a 1.5 x 1.5 x 0.8 cm irregular white smoothly lobulated mass with a rubbery, firm consistency located 1.5 cm from the lateral resection margin and 0.7 cm from the deep resection margin. No additional lesions are seen. The remainder of the breast parenchyma consists of grossly unremarkable adipose tissue with dense white fibrous stroma. Sections submitted as follows: Nipple 2&3 Superior margin with skin 4  Inferior margin with skin 5 Deep margin 6 Medial margin 7&8  Breast parenchyma adjacent to 4.5 cm mass  9-12 Composite section of 4.5 cm mass 13 Mass with necrosis 14-17 Additional sections of 4.5 cm mass 18 1.5 cm above described mass 19&20  Unremarkable breast tissue Page 5 of 6
+
+--- Page 6 ---
+SURGICAL PATHOL Report G. Received in formalin is a 420 gram right simple mastectomy specimen (15.5 x 15.0 x 4.5 cm) with a white-tan skin ellipse (11.5 x 9.0 cm). The nipple measures 1.7 cm in diameter and the areola measures 5.0 cm in diameter. The surgical resection margins have been previously inked black. The specimen has been previously cut. There Is a 3.5 x 3.0 x 1.0 cm firm, grey-tan mass wlth areas of calcification and hemorrhage, located in the upper outer quadrant as well as the. Jower outer quadrant. This mass lies within 1 mm of the nearest resection margin. No additional lesions are seen. The remainder of the breast parenchyma is dense-white fibrous stroma with unremarkable adipose tissue. Sections submitted as follows: 1 Nipple 2 Skin 3 Lower outer quadrant 4 Upper outer quadrant 5  Lower inner quadrant 6  Upper inner quadrant 7 Deep margin 8-11 Mass with nearest resection margin 12-17 Representative sections of mass H. Received in formalin is a fragment of skin with attached adipose tissue, measuring 14.0 x 1.5 cm. The skin is tan-white. and rubbery. No lesions are grossly noted. The specimen is unoriented. Tissue submitted in toto in two cassettes H1- H7. i. Received in formalin is an unoriented portion of white-tan skin with attached adipose tissue, measuring 6.5 x 3.0 x 2.5 cm. No lesions are grossly appreciated. Submitted in toto in two cassettes A1-A13.. Page 6 ot 6
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new file mode 100644
index 0000000000000000000000000000000000000000..ba0dde4826f76cf61101c4b503926e768486e826
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:F3FAB505-03FF-4FAA-ABB6-96AD20F47871 Redacted TCGA-E2-A574-01A-PR SPECIMEN(S): A. PAPILLOMA MEDIAL LEFT BREAST B. EXCISION LEFT BREAST CANCER C. SENTINEL LYMPH NODE #1 LEFT AXILLA D. SENTINEL LYMPH NODE #2 LEFT AXILLA CLINICAL HISTORY: 1) Cancer 2 cm in axillary tail left breast.. 2) Medial left breast mass -- Papilloma by core biopsy.. PRE-OPERATIVE DIAGNOSIS: None Given. INTRA-OPERATIVE DIAGNOSIS B: Lumpectomy, left breast, excision; margins check: Mass is located 0.2 cm from the. iCo-0-3 posterior margin. Reported to Dr. by Dr. Chcima, mifiHnstiNg chuct Nes 85rof3 Sif: busst,N05 C50.9 h DIAGNOSIS: 11/25/1 A. BREAST, LEFT MEDIAL, EXCISION: - INTRADUCTAL PAPILLOMA - APOCRINE METAPLASIA AND COLUMNAR CELL CHANGE - BIOPSY SITE CHANGES - SURGICAL MARGINS NEGATIVE FOR TUMOR B. BREAST, LEFT, EXCISION: - INVASIVE DUCTAL CARCINOMA, 2.3 CM IN GREATEST DIMENSION, SBR GRADE 3 - SURGICAL MARGINS NEGATIVE FOR TUMOR - BIOPSY SITE CHANGES - SEE SYNOPTIC REPORT C. LYMPH NODES, SENTINEL #1, LEFT AXILLA: - TWO LYMPH NODES NEGATIVE FOR METASTATIC CARCINOMA (0/2) D. LYMPH NODES SENTINEL #2, LEFT AXILLA: - TWO LYMPH NODES NEGATIVE FOR METASTATIC CARCINOMA (0/2) SYNOPTIC REPORT - BREAST Specimens Involved Specimens:  B: EXCISION LEFT BREAST CANCER
+
+--- Page 2 ---
+Specimen Type: Excision Needle Localization:.. Yes - For mass Laterality:Left Invasive Tumor:  Present Multifocality: No WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Tumor size: 2.3cm Additional dimensions: 2.1cm x 2cm Tumor Site: Not specified Margins:  Negative Distance from closest margin: 0.3cm deep Tubular Score: Nuclear Grade: 3 Mitotic Score: 3 Modified Scarff Bloom Richardson Grade: 3 Necrosis: Present Vascular/Lymphatic Invasion: None identified Lobular neoplasia: None Lymph nodes:  Sentinel lymph node Lymph node status: Negative 0/4 DCIS not present ER/PR/HER2 Results ER: Negative PR: Negative HER2: Negative by FISH Performed on Case: Pathological staging (pTN): pT2N0 Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition. GRSS DESCRIPTION: A. . APILLOMA MEDIAL LEFT BREAST Received fresh/in formalin labeled with the patient's identification and designated "papilloma medial left breast" is an oriented (single anterior, double lateral, triple superior), previously inked, 14 g, 4.3 x 3.2 x 2.1 cm needle localized excision. Ink code: anterior-yellow, posterior-black, medial-green, lateral-red, superior-blue, inferior-orange. The specimen is serially sectioned from medial to lateral into 7 slices revealing firm, focally hemorrhagic breast parenchyma. No lesions or nodules are grossly appreciated. Entirely submitted as per the attached diagram: A1: Perpendicular sections medial margin A2-A3: Slice 2, bisected A4-A5: Slice 3, bisected A6-A7: Slice 4, bisected A8-A9: Slice 5, bisected A10-A11: Slice 6, bisected A12-A13: Perpendicular sections lateral margin.
+
+--- Page 3 ---
+B. EXCISION LEFT BREAST CANCER Received fresh labeled with the patient's identification and designated "excision left breast cancer" is an oriented (triple - superior, double - lateral, single - anterior), 46 g, (Medial to lateral - 6.5 cm, superior to inferior - 5.4 cm, anterior to posterior - 3.5 cm) lumpectomy specimen. (The specimen is previously inked) Ink code: anterior-yellow, posterior-black, medial-green, lateral-red, superior-blue, inferior-orange. The specimen is serially sectioned from medial to lateral into 9 slices revealing a 2.3 x 2.1 x 2 cm, tan- white to tan-pink, firm to hard mass that is closest to the posterior margin at 0.2 cm, in. slices 6 to 9. Tissue is procured. Representatively submitted in 18 cassettes as per the attached diagram: B1: slice 1 entire, perpendicular sections of the medial margin B2: slice 2, representative anterior margin B3: slice 3, representative posterior margin with the mass. B4-B5: slice 4, sections of the mass showing the closest posterior margin, B6-B7: slice 5, mass with anterior and posterior margins B8: slice 5, superior margin B9-B10: slice 6, mass with anterior and posterior margins. B11: slice 6, inferior margin B12-B13: slice 6, superior margin B14-B15: slice 7, representative anterior and key and posterior margins. B16: slice 8, posterior margin B17-B18: slice 9, lateral margin, perpendicular sections.. C. SENTINEL LYMPH NODE #1 LEFT AXILLA Received in formalin with the patient's identification and designated "sentinel lymph node #1 left axilla" is a 3.2 x 1.5 x 1.2 cm fibrofatty tissue within which 2 lymph nodes, 2 x 1.3 x 0.7 cm and 2.5 x 1.2 x 1 cm are identified. The lymph nodes are serially sectioned and entirely submitted in 2 cassettes, C1-C2. D. SENTINEL LYMPH NODE #2 LEFT AXILLA Received in formalin with the patient's identification and designated "sentinel lymph node #2 left axilla" is a 3.5 x 2.5 x 0.8 cm fibrofatty tissue within which 2 lymph nodes,. 1.2 x 1 x 0.5 cm and 0.5 x 0.4 x 0.3 cm are identified. The lymph nodes are serially sectioned and entirely submitted in 2 cassettes, d1-D2.
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diff --git a/output/text/1fe93aa5-7ce1-4f4a-916e-c662848d9dc8.txt b/output/text/1fe93aa5-7ce1-4f4a-916e-c662848d9dc8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..dd38116a1fdc6b2e45b754b759e02f2364424208
--- /dev/null
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+
+--- Page 1 ---
+FINAL DIAGNOSIS: Part 1: AXILLARy SEnTinel NODe #1, RIght, BIOpSy - ONE LYMPH NODE, NEGATIVE FOR METASTATIC CARCINOMA. Part 2: breast. right, segmental mastectomy  A. InVasiye DuctaL. cARcinomA, nOttingham Grade 2 (tuBuLe formatiOn 3, nucLear grade 2, Mitotic Activity 1; tOtal ScOre 6/9). B. The TUmOr SiZe MEASUreS 1.8 Cm in GREATeSt DImenSiON (GROSS mEASUremeNT). C. DUctaL CArcinOma In SItu (DcIS), nuclEaR GRaDe 2, CRibRifOrm AnD SOLiD typeS. D. DCIS CONSTITUTES 15% OF TOTAL TUMOR VOLUME, MIXED AND AWAY FROM THE INVASIVE COmpONent. E. SURGICAL MARGINS ARE NEGATIVE FOR CARCINOMA; INVASIVE TUMOR IS 7 MM TO THE CLOSEST AnTeRIOR MARGIn, AND DCIS IS 7 Mm tO THE POSTeRIOr MARGiN. F. NO LyMPHOVASCULAR INVASION NOTED. G. FOCI OF MICROCALCIFICATIONS ASSOCiATED WITH INVASIVE CARCINOMA, DCIS, AND BENIGN BREAST TISSUE. H. NON-NEOPLASTIC BREAST TISSUE SHOWING FIBROCYSTiC CHANGES, DUCTAL EPITHELIAL HYPERPLASIA, COLUMNAR CELL CHANGE, AND SCLEROSING ADENOSIS. BIOPSY SITE CHANGES. J. THE INVASIVE TUMOR CELLS ARE POSITIVE FOR ER/PR AND NEGATIVE FOR HER-2INEU Part 3: breast, Anterior margin, Right, biopsy - A. BREASt TiSSUe wItH FIBROcyStIc CHAngE, nEgATiVe fOR CArciNOMA. B.  ENTIRE TISSUE SUBMITTED FOR MICROSCOPIC EXAMiNATION. Part 4: Breast, mediaLiposterior margin, Right, biopsy - A.  BREAST TISSUe WITH FIBROCYSTIC CHANGE, DUCTAL EPITHELiAL HYPERPLASIA AND SCLEROSiNG ADENOSIS. B. EnTire SPecimen SubmItted fOr micrOscOpic exAminatiOn. icD-0-3 CASE SYNOPSIS: Cauenons, nfi!tnutmy cuch! ios 850s/3 SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST Sitx:busst,nos e50.9 3/13/n hn LATERALITY: Right PROCeDUrE: Segmental LOCATION: Not specified SIZE OF TUMOR:  Maximum dimension invasive component: 1.8 cm. MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: No TUMOR TYPE (invasive component): Ductal adenocarcinoma, NOS HATIC INVASION: No PHATIC INVASION: Not applicable Yes, benign zones Yes, malignant zones. NVOLVED BY INVASIVE COMPONENT: No DE EXAMINATION: H/E stain, Keratin stain. pT1c UUID:EE9E0908-05D2-4F26-B3C2-2B40A48FEA6D Redacted pMX TCGA-BH-A0HI-01A-PR positive TORS: positive zero or 1+ 3/y
\ No newline at end of file
diff --git a/output/text/1fed5ea3-659b-4151-b053-424471b13bfa.txt b/output/text/1fed5ea3-659b-4151-b053-424471b13bfa.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9a5472c15e7305b099cbb0a7b9bc088393164dca
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+
+--- Page 1 ---
+SPECIMENS: A. RIGHT COLON, TERMINAL ILEUM DIAGNOSIS: A. RIGHT COLON, TERMINAL ILEUM, RIGHT HEMICOLECTOMY: - INVASIVE MODERATELY DIFFERENTIATED ADENOCARCINOMA OF THE COLON, WITH INVASION INTO SUBSEROSAL ADIPOSE TISSUE (4.2 X 3 X 0.7 CM). - ALL SURGICAL MARGINS OF EXCISION, NEGATIVE FOR NEOPLASM. - SEPARATE TUBULOVILLOUS ADENOMA, ADJACENT TO THE APPENDICEAL ORIFICE. - APPENDIX WITH FIBROUS OBLITERATION OF THE DISTAL PORTION. - PORTION OF TERMINAL ILEUM WITH NO SIGNIFICANT PATHOLOGICE CHANGES - SIXTEEN MESENTERIC LYMPH NODES, NEGATIVE FOR MALIGNANCY (0/16). - SEE TEMPLATE. COLORECTAL CANCER TEMPLATE Specimen Type: Right hemicolectomy Tumor Site: Right (ascending) colon Tumor Configuration: Ulceration Tumor Size: 4.2 x 3 x 0.6 cm Histologic Type: Adenocarcinoma Histologic Grade: G2: Moderately differentiated Extent of Invasion: Subserosa Margins: Margins uninvolved by invasive carcinoma (proximal. distal, radial) Venous/Lymphatic Invasion: Absent Perineural Invasion: Absent Additional Pathologic Findings: Adenoma Extent of Resection: R0: Complete resection with grossly and. microscopically negative margins Lymph Nodes: Negative (0/16) Implants: Absent Pathologic Stage: pT3a N0 Mx SPECIMEN(S): A. RIGHT COLON, TERMINAL ILEUM CLINICAL HISTORY: Not given GROSS DESCRIPTION: A. RIGHT COLON, TERMINAL ILEUM Received fresh for tissue procurement is a segment of terminal ileum with attached right colon. The terminal ileum is 4 cm in length and 4 cm in circumference and is grossly unremarkable. A segment of the right colon is 25 cm in length and 9.5 cm in maximum circumference. The serosal surface is tan- pink, smooth and grossly unremarkable. The attached appendix is 7 cm in length and 0.4 cm in diameter and shows unremarkable external and cut surfaces. The specimen is opened and shows a 4.2 x 3 x 0.6 cm tumor mass with central ulceration located at the mid portion of the right colon at 8 cm from the closest (distal margin) and 12.5 cm from the ileo-cecal valve. This lesion involves the portion of the colon which is not covered with serosa. It invades through the muscularis into the subserosa. A second polypoid lesion is identified in the area corresponding to the base of the appendix. This lesion measures 2.5 x 2.3 x 0.7 cm. Sectioning shows the lesion to be confined to the mucosa without definite evidence of invasion. The remainder of the colon shows an unremarkable tan pink mucosa. Throughout the pericolic adipose tissue, multiple presumptive lymph nodes are identified ranging between 0.3 and 0.6 cm in greatest dimension. All the lymph nodes and representative sections of the  specimen are submitted as follows:
+
+--- Page 2 ---
+A1: appendix A2: proximal margin A3: distal margin A4-7: sections of tumor A8-12:  sections of cecal polypoid mass in the area of the appendiceal orifice A13: uninvolved colon proximal to the tumor A14: uninvolved colon distal to the tumor A15-16: lymph node underlying the tumor A17-18: lymph node from the ileocecal artery region Tissue procurement was performed on the specimen. Gross photographs are taken of the specimen.
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diff --git a/output/text/1fef7be0-0d6d-415e-88b5-3b9fc07dc492.txt b/output/text/1fef7be0-0d6d-415e-88b5-3b9fc07dc492.txt
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index 0000000000000000000000000000000000000000..f4e89b81fe6aa499c1fbf585315ad081218ecde9
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+
+--- Page 1 ---
+1Cs-0-3 Carinmu,mif(t/ahng cuctl, N0s 850of3 Sih. bresst, N0s C5o.9 1/34/u h FOR OFFICIAL USE ONLY - PERBONAL DATA - PRIVACY ACT Or 1974 1 SURGICAL PATHOLOGY REPORT Patient: FMP/SSN: Specimen #: DOb/Age/Sex: Race: WHITE Taken: Location: Received: Physician(s) : Reported: SPECIMEN: A: LEFT BREAST B: SENTINEL LYMPH NODE #1 C: SENTINEL LYMPH NODE #2 AND #3 D: RIGHT BREAST FINAL DIAGNOSIS: A. BREAST, LEFT, MASTECTOMY: -INFILTRATING DUCTAL CARCINOMA, MODERATELY-DIFFERENTIATED -NOTTINGHAM SCORE IS 7 (3 TUBULES, 2 NUCLEI, 2 MITOSIS). -TUMOR SIZE 3.5 CM (GROSS MEASUREMENT). -DCIS PRESENT, CRIBRIFORM, NUCLEAR GRADE II WITH NECROSIS. -NO LYMPHOVASCULAR INVASION PRESENT. -SKIN AND NIPPLE ARE NOT INVOLVED. -MARGINS ARE NEGATIVE. B. SENTINEL LYMPH NODE, EXCISION: -ONE LYMPH NODE NEGATIVE BY H&E AND IMMUNOHISTOCHEMICAL STAINS. C. 1 SENTINEL LYMPH NODE #2 AND #3, EXCISION: -TWO LYMPH NODES NEGATIVE FOR MALIGNANCY BY H&E AND IMMUNOHISTOCHEMICAL STAINS. D. RIGHT BREAST, MASTECTOMY: -MILD FIBROCYSTIC CHANGES CONSISTING OF APOCRINE METAPLASIA, FOCAL DUCTAL DILATATION AND MILD FIBROSIS. AJCC STAGING:p T2 NO MX * * Report Electronically Signed Out * CLINICAL DIAGNOSIS AND HISTORY: -year-old female with breast carcinoma. UUID:F114D078-5F03-47F8-82AE-B8A21C2F9D31 TCGA-A2-A04X-01A-PR Redacted Page 1 Continued on Next Page - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 2 ---
+FOR OFFICIAL USR ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION: A. Received fresh, labeled with the patient's name,. designated "LEFT BREAST, LONG LATERAL, SHORT SUPERIOR" is a left mastectomy specimen. The specimen consists of a 921 gram left mastectomy specimen received fresh and oriented with a short suture superior and long stitch lateral. The specimen measures 23.0 cm from superior to inferior, 21.0 cm from medial to lateral, and 4.0 cm anterior to posterior. The 9.0 x 5.0 cm superficial skin ellipse is essentially located, 0.8 cm near the nipple free of discharge. No scars are noted. 'The superficial surface is. partially inked blue, the deep margin is inked black. ' Serial sections reveal a 3.5 x 2.5 x 2.2 cm firm, pink-tan, fairly well circumscribed mass in the mid outer breast. The mass is located 3.5 cm from the deep margin, and 0.8 cm from the superficial inked surface. Located 2.0 cm medial to this mass (also at the mid outer breast) is a 1.0 x 1.0 x 0.5 cm irregular nodularity, which, upon resection, appears to consist of a cystic fibrous. tissue. The cystic tissue is located 2.0 cm from the deep margin. The remainder of the specimen is composed of lobulated adipose tissue admixed with 50% focally cystic fibrous tissue, with this area located in the lower quadrant. No additional lesions are identified. No lymph nodes are identified. Representative sections are submitted as follows: Cassette Key:. Al: Skin. A2: Mass. A3: Mass with superficial margin.. A4: Mid outer cystic tissue.. A5: Upper outer quadrant.. A6: Upper inner quadrant. A7: Lower inner quadrant with margin 1.5 cm away.. A8: Lower outer quadrant. Matched sections of A1, A2, A4-A8 are submitted in ocr for cbcp protocol. Additional sections are submitted as follows: A9: Nipple. A10-Ali: Additional sections of mass.. A12-A13: Sections of the possible smaller mass and outer quadrant. 13cfss. B. Received fresh, labeled with the patient's name,. designated "SENTINEL LYMPH NoDE #1" is a firm, tan fragment of soft tissue measuring 0.7 x 0.6 x 0.3 cm. The specimen is bisected, and submitted entirely. Cut section reveals a variegated, tan, soft tissue. C. Received fresh, labeled with the patient's name,. designated "SENTINEL LYMPH NODE #2 AND #3" are two intact pink-tan lymph Page 2 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 3 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION (continued) : nodes with attached fatty tissue measuring 1.5 x 1.0 x 0.1 cm, and 1.0 x 0.7 x 0.4 cm.  These lymph nodes are submitted as follows: Cassette Key: c1: One lymph node bisected.. c2: Largest lymph node. A matched section of lymph node is submitted in OcT for cbcp protocol. There is also an additional portion of yellow,. adipose tissue that is submitted separately measuring 1.5 x 1.0 x 0.2 cm. This is submitted in cassette c3. 3CF D. Received fresh, labeled with the patient's name, designated "RIGHT BREAST, LONG LATERAL, SHORT SUPERIOR" is a right mastectomy specimen. Received fresh is a 609 gram right mastectomy specimen oriented with a short suture superior, and long stitch lateral.. The specimen measures 19.0 cm superior to inferior, 18.0 cm medial to lateral, and 3.0 cm anterior to posterior. The superficial skin ellipse measures 10.0 x 4.5 cm and displays a 1.0 cm centrally located, nipple. free of discharge. No scars are identified. The deep margins are inked black. Serial sections reveal densely fibrous breast  tissue admixed with approximately 10% adipose tissue. identified.  Representative sections are submitted as follows:  No discreet masses or lymph nodes are Cassette Key: D1: Skin. D2: Upper outer quadrant. D3: Lower outer quadrant. D4: Left inner quadrant. D5: Upper inner quadrant. Matched sections of D1 and D5 are submitted in. OcT for cBcp protocol. Additional sections are submitted as follows: D6: Nipple. D7: Upper outer quadrant. D8: Lower outer quadrant. D9: Upper inner quadrant. D10: Lower inner quadrant. 10CF Page 3 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 End of Report
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diff --git a/output/text/1ffdbdd2-81b0-4d4e-bd6d-9fffbc12197a.txt b/output/text/1ffdbdd2-81b0-4d4e-bd6d-9fffbc12197a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..95eb95909a4098ffa62ea0e3575d9546790bbe29
--- /dev/null
+++ b/output/text/1ffdbdd2-81b0-4d4e-bd6d-9fffbc12197a.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+ Pathology Examination: Histopathological examination Material: Multiple organ resection - segment of the large intestine Unit in charge: CGA-D5-5540 vateria collected on Materia mmcar aragnosrs: rumour or the cecum, right sided hemicolectomia. Examination performed on: Macroscopic description: 7 cm length of the large intestine with periintestinal tissue sized 15 x 12 x 4 cm, 12 cm segment of the small intestine, and 3 cm appendix. Tumour sized 3.3 x 2.7 x 0.8 cm found in the mucosa. The lesion surrounding 50% of the intestine circumference placed 12 cm from the proximal cut end and 7 cm from the distal cut end. Microscopic description: Adenocarcinoma tubulare (G2). In filtra tio carcinomatosa telae adiposae pericolicae. Intestine ends free of neoplastic lesions. Lymphonodulitis reactiva NO VIIl. Examination result: Including test No. Adenocarcinoma tubulare coli. (G2, Dukes B, Astler - Coller B2, pT3, pN0), TVRULAe. A>ENOCAe:NOMA OF THE COUN
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diff --git a/output/text/200fce8d-28cc-47df-80fa-83e3ee7d87b3.txt b/output/text/200fce8d-28cc-47df-80fa-83e3ee7d87b3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..55d987ee891df6465c11dec12db4ddd94cb679c3
--- /dev/null
+++ b/output/text/200fce8d-28cc-47df-80fa-83e3ee7d87b3.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+)cd-0-3 Carunome, mfiltratng durt N0S 85003 Site Code : breast, Nos C50.9 1x/2fo lw Final Diagnosis Breast, right,'wide local excision: Infiltrating ductal carcinoma, Nottingham grade II (of III) [tubules 3/3, nuclei 3/3, mitoses 1/3; Nottingham score 7/9], forming a mass (2.2 x 1.6 x 1.6 cm) [AJCC pT2]. Ductal carcinoma in situ is absent. Angiolymphatic invasion is absent. The non- neoplastic breast parenchyma shows nonproliferative fibrocystic changes. Biopsy site changes. are present. All surgical resection margins, after a separately submitted re-excision of the inferior margin, are negative for tumor (minimum tumor free margin, 0.5 cm, deep/superior margin).. Lymph nodes, right axillary sentinel, excision: Multiple (5) right axillary sentinel lymph nodes are negative for metastatic carcinoma [AJCC pN0 (i-) (sn)]. Blue dye is identified in all five right axillary sentinel lymph nodes. Immunohistochemical cytokeratin stain was performed on the paraffin embedded sentinel lymph node tissue and confirms the H&E impression. Her-2/NEU has been ordered on paraffin-embedded tissue. UUID: DA251274-7966-4F48-A02F-393ABBDAB4E9 Redacted TCGA-AR-A1AN-01A-PR
\ No newline at end of file
diff --git a/output/text/202cb605-962d-4827-aa11-18064c732fb2.txt b/output/text/202cb605-962d-4827-aa11-18064c732fb2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..64d7b5628f5dc3fe6f95701ce9731e5cb3869534
--- /dev/null
+++ b/output/text/202cb605-962d-4827-aa11-18064c732fb2.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+Requesting Doctor's Information:. UUID:15F6D8D6-878A-410F-8289-D3CEAB7E5D21 TCGA-OR-A5JG-01A-PR Redacted r A HISTOPATHOLOGY FOR REVIEW H 0 At the request ot the treating physicians and surgeons immunohistochemistry for L  multiple markers was performed on the adrenal cortical carcinoma removed in The Weiss score ot the tumour is 9. The mitotic rate is up to 0 100 per 50 HPF. G The immunohistochemical results are as follows: Y IGF2: Negative (score 0). Glucocorticoid Receptor: Focal weak staining (score 2+). Ki-67 proliferative index: 30% ACADVL: Positive REPORTING PATHOLOGIST: (Electronic Signature) A N IcD-6-3 A 8370|3 T S1te: DAdreuas E1aud, cor tex c74. 0 M FD sl3s/L3 1 c A L P A T 0 L pane 1 nf. 1 0
+
+--- Page 2 ---
+Specimen(s) Received 1Tumour lelt (2) Tumour near left renal artery (3) Tumour near left coelac artery (4) Adrenal gland and left kidney (5) Lymph node of greater curvature of stomach (6) Lymph node near splenic vein (7) Aetra aortic lymph node (8) Aorto-caval node in front of left renal vein (9) Tumour In tharacic duct (10) Left radical neck dissection (11) Peritoneal tiuid Clinical History. Tumour in thoraclc duct suggestive of adreno cortical cancer; peritoneal fluid; Tumour leit Tumour near left renal artery; Tumour near coeliac artery; Left adrenal gland and left kidney; Lymph node near great curvature of stonach; Lyrmph node near splenic vein; Rotro aortic lymph nodes; Aorto cable lymph nodes in tront. Of left renal vein; Left cervical zone Iv/vi lymph nodes. er Silk suture on thoraclc duct.e. Macroscopic Description (1) The specimen consists of a lobulated grey rodule. 15 x 8 x 5mm. (2) The specimen consists of two grey nodules 6 x 5 x 3mm and 6 x 3 x 2mm (3) The specimen consists of a grey nodule 12 x 12 x 12mm. (4) The specimen consists of a left kidney, left adrenal. gland, adjacent lymph nodes and surrounding. fatty tissue, together measuring 240 x 160 x 100mm (see photograph 1).. The kidney is 110 x 60 x 60mm and shows no signlflcant abnormality. (Continued page 2) Page 1 0t 4 Reterred by. .
+
+--- Page 3 ---
+The adrenal giand is 65 x 65 x 40rmm and expanded by a lobulated grey soud tumour (see photographs 2 & 3). Numerous replaced lymph nodes up to 4omm in diamster are presemt. The renal valn shows no significant abnormality (A: Kidney B-D: Adrenal tumour; E&F: Lymph nodes). :. (5) The specimen consists of a lymph node 15 x 10 x 10mn and adjacent fatty tissue. (A-8: RST). (6) The specimen consists of a lymph node 20 x 20 x 20mm and adjacent fatty tissue. (A-B: RST). (7) The specimen consists of fatty tissue 70 x 30 x 20mm containing iymph nodes up to 20mm in diameter. A-B:RST). (8) The specimen consists of fatty tissue 30 x 18 x 6mm containing lymph nodes 3-5mm in diameter. (9) The specimen consists of a piece of grey tissue 3 x 2 x 2mm. All ombedded. (10) The specimen consisis of a triangular plece of fatty tissue 60 x 20 x 20nm containing lymph nodes  up to 30mm in dlameter with a silk suture reaching one end of a portlon ot thoracic duct 15mm lona isee photograph 4). (A: Thorackc duct; B: Lymph node adjacent to thoracic; C&D: Other lymph nodes.) 3 Reterred by: Pago 2 ot 4
+
+--- Page 4 ---
+Mlcroscopic Description (1) - (3) Sectlons show nodules of metastatic adrenal cortical carcinoma arranged in shests and Islands. (4) Sections of the adrenal gland show adrenal cortical carcinona (see photograph 5) replacing the adrenal gland, with multiple nodules of matastatic adrenal cortical carcinoma close to the hllum of the kidney where the tumour abuts the resection margin. The tumour shows positive staining for Inhibin A and Melan A, with negative $taining for Cytokeratin, EMA and chromogranin. Proninent lymphatic invasion is present. The kidnoy shaws no evidence ot malignancy. Page 3 of 4 Referred by.. This documont is sud in accerdance wil
+
+--- Page 5 ---
+(5) -- (7) Sections show metastatic adrena) cortical carcinoma replacing lymph nodes. (8) Sections ot the lymph rodes show no evidance ot malignancy. (9) Sections show thorackc duct wall, with no evidenca of malignancy. (10) Sections of the lymph nodes show metastatic adrenal cortical carcinoma. The thoracic duct segment shows no evidence of malignancy. Final Summary TUmOUR, LEFt CRUS METASTATIC ADRENAL CORTICAL CARCINOMA TUMOUR, NEAR LEFT RENAL ARTERY : METASTATIC ADRENAL CORTICAL CARCINOMA TUMOUR, LEFT COELIAC ARTERY : METASTATIC ADRENAL CORTICAL CARCINOMA LEFT ADRENAL GLAND ADRENAL CORTICAL CARCINOMA LEFT XIDNEY NO EVIDENCE OF MALIGNANCY LYMPH NODES, GREATER CURVATURE OF STOMACH METASTATIC ADRENAL CORTICAL CARCINOMA LYMPH NODE NEAR SPLENIC VEIN : METASTATIC ADRENAL CORTICAL CARCINOMA RETRO AORTIC LYMPH NODE METASTATIC ADRENAL CORTICAL ** CARCINOMA AORTO CAVAL NODE IN FRONT OF LEFT RENAL VEIN NO EVIDENCE OF MALIGNANCY TUMOUR, IN THORACIC DUCT NO EVIDENCE OF MALIGNANCY LEFT RADICAL NECK DISSECTION METASTATIC CORTICAL ADRENAL CARCINOMA 412 Reported By: Paga 4 of 4 Roferred by: Or
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diff --git a/output/text/204ea5b2-6789-4291-bb5a-42023e9befc6.txt b/output/text/204ea5b2-6789-4291-bb5a-42023e9befc6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c1188a3a6854ea890549732fcc9cea62310bdaa8
--- /dev/null
+++ b/output/text/204ea5b2-6789-4291-bb5a-42023e9befc6.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+UUID:485F752A-74F7-4E48-8921-E4E5D1AE712D TCGA-FG-A4MY-01A-PR Redacted 1cs-0-3 Oligoastrocytoma 938s/3 Surgical Pathology Report. 10/4/1) Clinical History - Brain tumor [239.6]. Medical history: Drug abuse cocaine type. Ethyl alcohol abuse. Benign essential hypertension. ADDENDA: Addendum added: Addendum added: -Final Pathologic Diagnosis-. A. Right parietal temporal brain biopsy: Low grade glioma. See comment.. B. Right parietal temporal mass excision: Low grade glioma (who grade II). See comment. commenc: Thougn the cumor is composed predominantiy of oligodendroglial elements, areas of nuclear pleomorphism with GFAp positivity raises the possibility of an astrocytic component. Assays for 1p and 19q are pending and a definite lineage will be rendered once the report is available. All controls show appropriate reactivity. The immunohistochemical and/or in situ hybridization tests reported here except for those addressing HER-2/neu overexpression, have been developed and their performance characteristics determined by the Immunohistochemistry and Histology Core Facility laboratories in the Department... of... Pathology- at. and arenot yequired.. have nor do they have FDA approval.
+
+--- Page 2 ---
+Page 2 --Addendum Report--- Addendum Status: Signed Out Detection of 1p36 and 19q by LSIe 1p36/LsI 1q25 and LSI 19ql3/19p13 Dual-Color Probe Sets Pathology Core Facility, Molecular Diagnostic Laboratory. Case No Outside Case#: Pathologist Patient Name:. Source of case Patient MRN: Block used B4 Tissue fixation formalin-fixed tissue Tissue source Brain RESULTS Ratio of 0.89 Cell count of lp/lq: 142 Ratio of 0.70 Cell count of 19q/19p:. 131 Interpretation of Results: A) 1p no loss;. B) 19q loss Interpretation of findings: A) (negative) The majority of tumors cells displayed 2 to 3 control. chromosome lq25 signals and 2 to 3 chromosome 1p36 signals. (locus of interest), and the ratio of 1p36/lq2s Ratio was >0.8.. The results are consistent with no loss of the lp36 locus of interest.. B) (positive) The majority of tumors cells displayed 2 control chromosome 19pl3 signals and i chromosome 19ql3 signals (locus of interest). The ratio of 19q13/l9pl3 is <0.8. The results are. consistent with the loss of lp36 locus of interest.. Number of Observers: 2 Test Interpreted By: Comments The resultant Fish section/slide is scanned by a trained licensed medical technologist and analyzed using a FDA-approved, validated semi-automated scanning imaging workstation.  and accompanying imaging. analysis software The resultant Fish section/slide is then. presented to the interpreting Pathologist, who will reviews the FISH. results from and compares them to the results manually observed under an Olympus Fluorescence Microscope. Therefore the ratio is enumerated. by computer-aided counting as well as manual counting.. Interpretation of Test The ratio for probe set 1 is derived by dividing the total number of. LSI lp36 signals by the total number of LsI 1q25 signals in at least 20 interphase nuclei with. nonoverlapping-nuclei-in the-neoplastic glial cells. Cells with no signals or with signals of only one color are disregarded. The ratio for probe set. 2 is derived by dividing the total number of Lsr 19ql3 signals by the total.
+
+--- Page 3 ---
+Page 3 F/ number of LsI 19pi3 signals in at least 2 sets of 20 interphase nuclei with nonoverlapping nuclei in the neoplastic glial cells at two different areas of the sample. Cells with no signals or with signals of only one color are disregarded. References ranges for our laboratory for allelic loss versus no allelic loss were established by evaluating both probe sets in a series of 40 normal cases from 10 different organs. For both probe set 1 and 2 a ratio of less than 0.80 taken from at least 2 sets of 20 interphase nuclei at 2 different areas with nonoverlapping nuclei is consistent with allelic loss. Frsh and H&&E stained slides have been reviewed by the interpreting pathologist. Limitations ANALYTE SpECIFIC REAGENT: The use of one or more reagents in the above tests is regulated as an analyte specific reagent (Asr). These tests were developed and their performance characteristics determined by the Pathology Core Facility of. They have not been cleared by the Us Food and Drug Administration. Tne FDA has determined that such clearance or approval is not necessary. Addendum Status: Signed Out A and B: Right parietal temporal region, excision - Mixed oligoastrocytoma (who grade II). Assays detect intact ip and deletion of 19q loci. - INTRAOPERATIVE CONSULTATION DIAGNOSIS: -- AF1. Right sided parietal temporal tumor (frozen section performed): Infiltrating glioma. Note: Examining pathologist - -mIcroscopic: -- Sections reveal an infiltrating glial neoplasm composed of cells having mostly round to ovoid nuclei and scant cytoplasm. Mitotic figures are rare. Background slender vasculature is seen. In areas, the cells display nuclear pleomorphism and eosinophilic cytoplasm with processes. Immunostain for GFAp is positive in these areas and a Ki-67 stain shows a proliferation index of about 3t, by manual quantification.
+
+--- Page 4 ---
+Page 4 F/ -SPECIMEN(S) RECEIVED:: A: Neuropath, Brain, Bx B: Neuropath Reg - -GROSS DESCRIPTION: - The specimens are received in two properly labeled containers, one of which. is submitted for frozen section with the patient' s name and accession number. A. The specimen is designated "right sided parietal temporal tumor" and consists of two pieces of tissue 0.8 x 0.5 x 0.2 cm in aggregate. The specimen is entirely frozen. TE 1 Summary of Cassettes: AFl, remaining frozen section tissue resubmitted as received B. The specimen is designated "right sided parietal temporal tumor" and consists of a 6.0 x 4.5 x 1.5 cm aggregate of pink-tan to. 6 Lab Use Only: Gross description by:
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diff --git a/output/text/207640da-0c4b-48b7-9980-02e0da418174.txt b/output/text/207640da-0c4b-48b7-9980-02e0da418174.txt
new file mode 100644
index 0000000000000000000000000000000000000000..68d892d52e9353459fdd8bec83b83623bd94954a
--- /dev/null
+++ b/output/text/207640da-0c4b-48b7-9980-02e0da418174.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:4C19CF84-5E30-4854-A084-F6EE53A80543 tCgA-2y-a9h2-01A-pr Redacted Pathology Report Final Diagnosis A. LIVER, LEFT LATERAL SEGMENT 3, EXCISIONAL BIOPSY: Bile duct hamartoma. B. LIVER, LEFT LATERAL SEGMENT, EXCISION: Benign hepatic parenchyma, negative for carcinoma. C. LYMPH NODE, PERIPORTAL ADENOPATHY: One lymph node free of malignancy (0/1). D. LIVERANDGALLBLADDER.LIVER SEGMENTS4B AND5,HEPATIC SEGMENTECTOMY ANDCHOLECYSTECTOMY: Hepatocellular carcinoma, poorly differentiated, with sclerotic stroma. Carcinoma invades into the subserosa of the gallbladder. Perineural invasion identified. No lymphatic or venous invasion identified. Hepatic parenchymal margin is free of malignancy, see Key Pathological Findings. I, the attending pathologist, personally reviewed the entire case and rendered the final diagnosis. Electronically Signed Out by IcD-0-3 areun oma, JeesitoeellerSser No5 Key Pathological Findings 81703 D: Liver, Resection, Synoptic Data Site. sLuer C22.D SPECIMEN TYPE: 4B AND 5 SEGMENTECTOMY FOCALITY: Solitary (specity location): segment 4b and 5 )4/Q8[1<) TUMOR SIZE: 3.4 cm HISTOLOGIC TYPE: Hepatocellular carcinoma HISTOLOGIC GRADE:Gll: Poorly differentiated PRIMARY TUMOR (pT): pT1: Solitary tumor with no vascular invasion REGIONAL LYMPH NODES (pN): pNO: No regional lymph node metastasis Number examined:1 Number involved:0 DISTANT METASTASIS (pM): pMX: Cannot be assessed MARGINS: Parenchymal margin uninvolved by invasive carcinoma Bile duct margin cannot be assessed *VENOUS (LARGE VESSEL) INVASION (V): *Absent *ADDITIONAL PATHOLOGIC FINDINGS: *None identified Specimen(s) Received A LEFT LATERAL SEGMENT 3 EXCISIONAL BX OF LIVER FS B LEFT LATERAL SEGMENT 2 NODULE FS c PERIPORTAL ADENOPATHY FS
+
+--- Page 2 ---
+D LIVERSEGMENT4B AND 5 AND GALLBLADDER -GROSS EXAM Clinical History HCC. Preoperative Diagnosis Hepatocellular carcinoma. Frozen Section Diagnosis FSA1LEFT LATERAL SEGMENT 3: Bile duct hamartoma.. FSB1  LEFT LATERAL SEGMENT 2 NODULE: Negative for carcinoma FSC1 PERIPORTAL ADENOPATHY: Reactive lymph node. No evidence of malignancy. Comment: This trozen section diagnosis/result was communicated to and acknowledged by. in at per Intraoperative Consultation D LIVER AND GALLBLADDER: Lesion grossly measures 1.1 cm from parenchymal margin. Gross Description A.  Specimen A is received fresh for frozen section labeled *left lateral segment 3 excisional. biopsy." The specimen consists of a 1.5 x 1.0 x 0.5-cm, tan-gray, soft tissue, which is entirely. submitted for frozen section labeled FSA1. B. Specimen B is received fresh for frozen section labeled *left lateral segment 2 nodule." The. specimen consists of a 1.2 x 0.3 x 0.2-cm, tan-gray, soft tissue, which is entirely submitted for frozen. section labeled FSB1. C Specimen C is received fresh for frozen section labeled "periportal adenopathy.* The specimen consists of a 1.8-cm lymph nade with a small amount of attached fat. The lymph node is bisected and entirely submitted for frozen section labeled FsC1. D Specimen D is received fresh labeled "liver segment 4B and 5, and gallbladder.* The. specimen consists of a 116-g, 8.6 x 5.1 x 4.3-cm wedge of liver with an adherent 8.7 x 3.3 x 2.2-cm gallbladder. The capsule is indurated surrounding the adherent gallbladder with a small amount of attached fat. Sectioning through the liver at the adherent gallbladder reveals a circumscribed, 3.4 x 2.7 x 2.4-cm, gray-white tumor, which extends to the overlying capsule to the soft tissue surrounding. the gallbladder. No extension into the gallbladder wall is identified. The tumor is 1.1 cm from the
+
+--- Page 3 ---
+parenchymal margin. The surrounding parenchyma is dense, tan-brown. On opening the gallbladder. tan-green, and the wall measures 0.1 cm in thickness. The fat adjacent to the neck of the neck of the gallbladder is focally indurated. The medial parenchymal margin is inked red, fateral yellow, superior. blue, and deep black. The fat attached to the liver capsule is inked green. Representative sections are submitted labeled. D1-3: Tumor to adherent gallbladder D4: Tumor to closest parenchymal margin D5: Tumor to adherent fat D6: Lumen at parenchymal margin D7: Tumor to capsule and adjacent parenchyma D8: Gallbiadder, cystic duct margin D9: Fat attached to gallbladder neck D10-11: Fat attached to tiver capsule Tissue from specimen D is submitted to tissue procurement laboratory..
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diff --git a/output/text/209fd763-0df8-4740-8ed8-782a85066322.txt b/output/text/209fd763-0df8-4740-8ed8-782a85066322.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b3ce5357880b2579b871923cb1961ca72513213c
--- /dev/null
+++ b/output/text/209fd763-0df8-4740-8ed8-782a85066322.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+ICDo-3 Carcnmn, Adveuol CrticaI 837o/3 R-A5KV-01A-PR Redacted Site: DAdreua! Gand Corte C74.O OO2/s13 Procedure: left adrenalectomy Gross description: 12 x 11 x 11cm, 641g Diagnosis: adrenocortical carcinoma, well differentiated, G1 Reference Pathology: none 4/12f1z- Pu mw pa,Wuiss =3 wrH LN iNvrlunt:Maigmr Sms-if ouu Mey cnf shsy F mt nuliy
+
+--- Page 2 ---
+Patient # from Tissue Source Site Date of report. Date of Surgery/specimen collection Site (confirmed to be adrenal) with laterality indicated Left Tumor size(s) 12x11x12cm Histologic diagnosis ACC Lymph Node Status 1/x Pathologic  information T2N1Mx Weiss score. Min. 3
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diff --git a/output/text/20bc24e3-dac1-4fb5-8e69-18041d320026.txt b/output/text/20bc24e3-dac1-4fb5-8e69-18041d320026.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2a39a86537ff352062c523cd63b42c5ba3ab9665
--- /dev/null
+++ b/output/text/20bc24e3-dac1-4fb5-8e69-18041d320026.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+/cD-0-3 0drwcuvuiomL nos 81yo/3 Sit: Signoid colon c18.1 3/09/ Sample ID #: Diagnosis: 1.: Normal, tumor-free gall bladder with no macroscopic or microscopic indications of. the presence of a polyp and with no notable florid or chronic inflammatory changes. Two. tumor-free perivesicular lymph nodes.. 2.: A further tumor-free lymph node.. 3.: Resectate of the colon (sigmoid colon) with tumor-free oral and aboral resection. margins and under inclusion of an ulcerated, moderately differentiated adenocarcinoma. with penetration of all layers of the wall, penetration of the peritoneum, encroaching on the subserosa of a segment of the small intestine in the vicinity and with a solitary. regional lymph node metastasis (G2, pT4 L1 V0 pN1 1/31). UUID:7F67E829-D10E-4B47-B0A1-6029857ED112 TCGA-AA-A00Q-01A-PR
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diff --git a/output/text/20d74166-5701-4e9d-98e6-32f4ba636ea5.txt b/output/text/20d74166-5701-4e9d-98e6-32f4ba636ea5.txt
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+FINAL SURGICAL PATHOLOGY REPORT Diagnosis: A.DISTAL STOMACH, DUODENUM,HEAD OF PANCREAS PANCREATICODUODENECTOMY (WHIPPLE RESECTION): -DUCTAL ADENOCARCINOMA,WELL DIFFERENTIATED. - 3.1 cm in maximum dimension. - Tumor invades ampulla of Vater and peripancreatic soft tissue. -MARGIN STATUS: POSITIVE. - Tumor extends to the superior peripancreatic soft tissue margin. - Distal pancreatic, bile duct, and retroperitoneal margins are negative. for tumor. -FOUR OF THIRTEEN LYMPH NODES,POSITIVE FOR METASTATIC CARCINOMA (4/13) -PERINEURAL INVASION:NOTIDENTIFIED -SEE PATHOLOGIC TUMOR STAGING SUMMARY BELOW. B.UTERUS (74 GRAMS), LEFT FALLOPIAN TUBE AND OVARY, AND RIGHT ADNEXAL MASS,HYSTERECTOMY AND LEFT SALPINGO-OOPHORECTOMY: ENDOMETRIUM: -Inactive endometrium. - Negative for hyperplasia, neoplasia, and endometritis. MYOMETRIUM: - Leiomyomata uteri (largest 2.2 cm in greatest dimension). -Adenomyosis. SEROSA: - Negative for adhesions and endometriosis.. LEFT OVARY: - Unremarkable ovarian tissue, negative for adhesions and endometriosis.. RIGHT ADNEXAL LESION: - Leiomyoma (4.5 cm in greatest dimension) - Negative for cytologic atypia, increased mitotic activity and necrosis.
+
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+FINAL SURGICAL PATHOLOGYREPORT C.APPENDIX,APPENDECTOMY: -UNREMARKABLE VERMIFORM APPENDIX. -FECALITH. D.GALLBLADDER,CHOLECYSTECTOMY: -ACUTE AND CHRONIC CHOLECYSTITIS E.RIGHT OVARY AND FALLOPIAN TUBE, SALPINGO-OOPHORECTOMY: -OVARIAN SEROSAL ADHESIONS -UNREMARKABLE PORTION OF FALLOPIAN TUBE -NEGATIVE FOR ENDOMETRIOSIS PATHOLOGIC TUMOR STAGING SUMMARY: Type and grade: Ductal adenocarcinoma, well differentiated. Primary tumor: pT3 (extends beyond the pancreas, but does not involve the celiac axis or superior mesenteric artery).. Regional lymph nodes: pN1 (four of thirteen lymph nodes, positive for metastasis). Distant metastasis: Not applicable.. Pathologic stage: IIB. Lymphovascular invasion: Present.. Margin status:Rl (tumor extends to superior peripancreatic soft tissue margin). Tumor Staging Information Data derived from current specimen. Staging in accordance with or modified from AJCC Cancer Staging Handbook and CAP protocol,
+
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+Specimen: Head of pancreas, duodenum, distal stomach, gallbladder Procedure: Pancreaticoduodenectomy (Whipple resection), partial pancreatectomy. TUMOR FEATURES: Tumor site: Pancreatic head. Tumor size: Greatest dimension:3.1 cm Histologic type: Ductal adenocarcinoma Well differentiated (G1). Histologic grade: Tumor invades ampullar of Vater and peripancreatic Microscopic tumor extension: soft tissue. MARGINS: POSITIVE (R1) POSiTIVE, at superior peripancreatic soft tissue Distance of invasive carcinoma from closet margin: margin. Uninvolved by carcinoma Other margins: Treatment effect: Not applicable Present. Lymphovascular invasion: Not identified. Perineural invasion: LYMPH NODES: Thirteen lymph nodes, four positive for metastatic carcinoma, PATHOLOGIC TUMOR STAGING DESCRIPTORS pT3 (tumor extends beyond the pancreas,without Primary tumor: involvement of the celiac axis or the superior mesenteric artery). pN1 (4/13 lymph nodes positive for metastatic) Regional lymph nodes: carcinoma). Not applicable Distant metastasis: IIB Pathologic stage: R1 (tumor extends to superior peripancreatic soft tissue Margin status: margin).
+
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+FINAL SURGICAL PATHOLOGYREPORT Source of Specimen: A.Whipple B. Left tube, ovary, uterus, and right adnexal mass C.Appendix D.Gallbladder E. Ovary and fallopian tube;right Intraoperative Diagnosis: A.Whipple procedure:Pancreatic mass, pelvic mass:FSA1) pancreatic margin negative.FSA2) Bile duct margin negative. The intraoperative interpretation(s) was/were performed and rendered at B. FS: Left tube, ovary, uterus and right adnexal mass: Favor leiomyoma The intraoperative interpretation(s) was/were performed and rendered at Gross Description: A. The specimen received at this time previously designated as #3, now designated as part A Whipple procedure. Initially received in a fresh state for frozen section analysis is a generous portion of tissue consistent with a Whipple procedure, consisting of a 10.3 cm distal portion of gastric tissue,4.5 cm in diameter at the proximal margin of resection, a 17.5 x 3.2 cm fragment of small bowel, and the head pancreas measuring:3.4 cm in length,4.8 cm superior-inferior, and 4.3 cm anterior surface to posterior uncinate margin.The common bile duct extends 0.7 cm, and is 1.2 cm in diameter,with the dilated 0.6 cm lumen involved with a metallic mesh stent. The surface of the pancreas is now differentially inked as follows: anterior-yellow, inferior-green, posterior uncinate-black, superior-blue, pancreatic notch/medial surface-red.The gastric and small bowel serosa demonstrates a glistening hyperemic appearance.The length of gastrointestinal tissue is now opened to reveal luminal contents of blood tinged mucinous fluid, that is cleared to reveal erythematous pink and tan gastric mucosa, with the small bowel circular plicae prominent, semi-congested distally, to light pink and tan.At 3.5 cm distal to the pylorus is a 0.2 cm unremarkable ductal orifice that is probe patent with the pancreatic duct through the distal margin. This ductal tract perpendicularly bypasses the common bile duct without involving the CBD lumen.At 1.1 cm distal to the pancreatic duct orifice, or 4.6 cm distal to the pylorus and 12.9 cm from the distal small bowel margin resection, a prominent ampulla, with a 1.0 cm Iumen, demonstrates obvious communication with the common bile duct and involved with a metallic mesh stent. The stent is sectioned lengthwise and removed, revealing a waffled-granular, deep red
+
+--- Page 5 ---
+FINAL SURGICAL PATHOLOGY REPORT congested mucosa. The small bowel periphery of the ampulla is raised, semi-congested and granular, over an area of 2.2 x 1.5 cm, with the immediate transition in the common bile duct suspiciously raised The pancreatic margin and the common bile duct margin are now shaved and submitted for frozen section analysis, with residual frozen tissue submitted for permanent sections. Sectioning through the pancreas, medial and posterior to the common bile duct tract, demonstrates diffusely dense, light gray cut surface,with mucin filled spaces up to 0.2 cm, grossly suspicious for malignant change. These changes grossly approach within 0.1 cm of the posterior margin of the uncinate and 0.1 cm of the superior-medial inked surfaces.This possible mass lesion is up to 3.1 x 1.8 cm.The remaining cut sections of the pancreas toward the anterior surface and distal margin of resection demonstrates tan, lobular, glandular parenchyma, grossly uninvolved with tumor, with exception of a 0.6 cm focus, suspicious for tumor involvement near the pancreatic groove periphery, and within 0.9 cm of the pancreatic distal margin of resection (A11). Examination of the peripancreatic fat reveals thirteen Iymph node candidates ranging from 0.3 cm to 1.4 x 0.9 cm. Examination of the discrete portion of perigastric fat reveals two lymph node candidates, 0.3 and 0.4 cm each. Representative sections are submitted including entire submission of lymph node tissue candidacy. Cassette summary: A1) distal pancreatic surgical margin, frozen section, A2) common bile duct surgical margin, frozen section,A3) pancreatic ampulla represented, A4-A5) common bile duct ampulla, possible tumor involvement, including pancreas, three pieces, A6) common bile duct length represented, posterior pancreas, possible tumor, A7) posterior surface of uncinate, possible tumor involvement,three pieces, A8) superior pancreas adjacent common bile duct, possible, two pieces, A9-A10) superior pancreas, pancreatic groove surface, possible tumor involvement, four pieces,A11) bulk of distal extension of pancreas, including inferior margin, possible tumor relationship, A12) additional representation of inferior pancreas, including mesenteric/pancreatic groove surface, A13) anterior pancreas represented, three pieces, A14) proximal gastric margin of resection represented, A15) distal small bowel margin of resection represented, A16) antrum of stomach,pylorus represented, two pieces, A17) representation of loop-distal duodenum, A18) six peripancreatic lymph nodes candidates, A19) four peripancreatic lymph node candidates, A20) fragmented peripancreatic lymph node candidate, A21) single peripancreatic lymph node candidate bisected, A22) single peripancreatic lymph node candidate bisected, grossly involved with tumor, A23) two gastric lymph node candidates, A24) perigastric fat, possible lymph node content. B.Part B designated left tube, ovary,uterus, and right adnexa mass - stitch. Initially received in a fresh state for frozen section analysis is a supercervical hysterectomy specimen with attached left fallopian tube segment and ovary, and right adnexal mass. The right adnexal mass measures 4.5 x 3.7 x 3.5 cm and is encapsulated and partially glistening pink-red soft tissue. Sectioning reveals an encapsulated -well circumscribed rubbery, yellow-tan nodular cut surface, with a faint whorled appearance, grossly consistent with a leiomyoma. Two representative sections are submitted for frozen section analysis with residual frozen tissue submitted in B1 for permanent sections. The right fallopian tube segment and ovary is not appreciated, nor placed within the container, and the left adnexal tissue is now removed, to demonstrate a 74 gram uterine corpus including attached "right adnexal mass" measuring 5.7 cm superior to inferior, 4.5 cm cornu to cornu and 2.4 cm posterior-anterior. The uterine serosa is partially glistening light pink to congested deep purple-red. The uterine corpus is now bisected, revealing a triangular endometrium, 1.9 cm cornu to cornu and 3.0 cm in length, flattened light tan to focally congested deep red, and 0.1 cm in thickness.The dome of the fundus demonstrates an additional circumscribed whorled appearing nodular
+
+--- Page 6 ---
+FINAL SURGICAL PATHOLOGY REPORT mass, 2.4 x 2.2 cm. The myometrium is rubbery semi-congested pink and tan and includes an additional 0.4 and 1.3 cm whorled appearing and somewhat degenerated yellow-gray nodules.. The left fallopian tube segment with fimbria is 4.7 x 0.4 cm congested deep red, with a delicate light tan lumen. The attached ovary is glistening bosselated pink-yellow, 2.4 x 1.7 x 1.3 cm. The ovary is partially cinched by a black suture, removed and the ovary is sectioned to demonstrate a soft to rubbery grossly atrophic pink and yellow-gray cut surface. Examination of the cinched area demonstrated increased indurated changes, including a 0.3 cm cyst, this area is entirely submitted for microscopic evaluation. The remaining cut sections of the ovary reveal discrete nodularity or grossly unusual areas of change suggestive of neoplasia.Representative sections are submitted. Section summary: B1) frozen section, "right adnexal mas", B2) cervical stump/distal margin of lower uterine segment, B3-B4) endomyometrium,including smallest nodularity,B5) large nodular mass and dome of fundus, second larger intramural mass represented, three pieces total, B6-B7) additional representation of large right adnexal mass, including surrounding margins, six pieces, B8) left fallopian tube and ovary represented. C. Part C designated appendix. Received is a container initially designated as part 1 appendix and part 2 gallbladder, includes a vermiform appendix, 7.0 cm in length, and 0.6 cm in diameter. The serosa is hyperemic pink and tan. Sectioning demonstrates a lumen dilated up to 0.4 cm containing loose green fecal matter.The apex demonstrates stenosis of lumen, thickened yellow-gray appearance. omission of the apex, bisected, mid length, and Representative sections are submitted to include entire proximal margin of resection represented (blue) in C1. D. Part D designated gallbladder. Received in formalin is a container formally designated as #1 appendix and #2 gallbladder, is a gallbladder, 7.0 x 2.6 x 1.5 cm.The serosa is glistening lightly fatty congested purple-red. The bile duct margin is received opened, demonstrating an obvious patent 0.3 cm lumen exuding hemorrhagic mucin. Examination of the attached fat near the cystic duct margin does not reveal Iymph node content. The wall is 0.2 to 0.4 cm including serosal fat, and the lumen includes hemorrhagic mucin and blood clot, without calculi. The material is cleared to reveal velvety congested deep red mucosa with a few raised yellow flecks. No grossly unusual areas of change suggestive of neoplasia. Representative sections are submitted for microscopic evaluation in D1 E. Part E designated as right tube and ovary.Received in formalin is a 6 gram portion of adnexal tissue, that includes a 4.0 x 0.3 cm fallopian tube segment with fimbria, and an attached 2.4 x 1.1 x 0.8 cm.The fallopian tube is hyperemic pink and tan, with a delicate light tan lumen. Sectioning through the ovary demonstrates a soft to rubbery semi-congested pink and yellow-gray, grossly atrophic parenchyma. No discrete nodularity or grossly unusual areas of change suggestive of neoplasia.Representative sections are submitted, to include entire submission of the ovary, and representation of the fallopian tube in E1 and E2 Microscopic Description: A.Microscopic sections have been examined.The microscopic findings are reflected in the diagnosis rendered.
+
+--- Page 7 ---
+FINAL SURGICAL PATHOLOGY REPORT B. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered. C. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered. D. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered. E. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered.
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diff --git a/output/text/20d9ba0b-10fa-4619-aa50-b346bd2989f3.txt b/output/text/20d9ba0b-10fa-4619-aa50-b346bd2989f3.txt
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index 0000000000000000000000000000000000000000..5f9c6282ca4406938a50f88f430d068b42cdb6fd
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+iD-O-3 Resuit Type: Surgica! Pathology Report Result Date: lrcenomo, yDopisosy Performed By: Encounter Infot ^enaI eelL''8Q6OX3 Surgical Pathology Report Sik DYuuyNoS JC649 8/9[13 Surgical Pathology Report DIAGNOSIS: A. Left lower pole renal cyst wall: There is no avidence of malignant twsor .3. Para-aortic lymph node, biopsy: Six lymph nodss negative for metastatic carcinoma. C. Left renal sass, partial nephrectomy: Papillary renal cell Partial nephre Cmy, left kidney. Histologic type xenal cell c Nuclear grade i (of 4 grades). Tumoz size: 4.0x3x3c Tumor site: Lower pole. rumor foc Absent Microscopie tumor axtension: fumor necrosis Confined to renal parenchyms without extension into perinephric tissue, Gerota's fascia, renal sinus, renal vein, or collecting systen. Surgical Negative for tumor Lyaph-yasculaz iavasion: Absent. Pathologic findings in kidney: No diagnostic abnormalities. Pathologic staging: pTla, pNO. Not applicable UUID:9E7F5190-947D-4A9E-96A2-ED94CF65E109 TCGA-SX-A71R-01A-PR Redacted CLINICAL INFORMATION: Left renal mass SPECIMEN(S) : A:Laft iower pole renal cysts wall AI B1B2 C1C2 C3 C4 C5 C6 GROSS DESCRIDTION: Parformed by and "left lower pole cissue 31.00 cassette Al}. and *periaortic lymp nodes" is a portion of fibrofatty tissue, 5.0 x4.0 x 1.5 cm. tissue contains six possibls lymph nodes that are from 0.6 cm to 2 nitted in two cassettes Bl and B2 ne bise Procedure: Partial nephrectomy. Specimen laterality: Left. Tusor site: 4.0 pole 0 x 3.0 cm. focality Unifocal Gross Extension into perinephric tissue: Absent. extent Extension i into renal sinus: Absent. Extension into renal vein: Absent. into collecting systen: Absent. Adrenal gland: Gross Notes: Gross tumor characteristics: Prsdominantly cystic, containing red-brown friable materisi with a rim of solid yeliou-orange tiss 45 grams with fat: 30 grams without fat. 6.0x4.03.0 cm. Jreter dimensions: 0.2-0.3 Inking details: Faranchyeal nargin black, peripheral perinephric fat margin blue. Block ary for specinen C: C1-4. tmal kidney and parenchyma wargin. C5 Seetion corresponding to tissue subaitted for research C6. Peripheral perinephric fat margin. riteria 9 Support for the diagnosis in this case may have includad the iagnosis Discrepan imary Fumor Site Disc perforaance datazmined by They have not been cleared uai/SynchronousP ary Nate Th. Fba has determined that such ciaarance or approvai i not ase is (circle): HAUFED) DISQUALIFIED necessary. Thess tests. should not be regarded as investigationel eviewer ritialsDate Reviewed Laboratory Improvement Amsndn. of 1998 7cLIA)as qualified to perform high complexity clinical laboratory testing.
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diff --git a/output/text/20df317f-ee81-451d-9b63-81c09d122131.txt b/output/text/20df317f-ee81-451d-9b63-81c09d122131.txt
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+DIAGNOSIS: 1. Soft tissue, "psuedocapsule/lateral" (excision): Fibroadipose tissue, no tumor seen. 2. Soft tissue, "anterior perirenal fat" (excision): Adipose tissue, no tumor seen. 3. Soft tissue, "perirenal fat - upper pole" (excision): Adipose and fibrous tissue, no tumor seen. 4. Soft tissue, "scar tissue" (excision): Fibroadipose tissue, no tumor seen. 5. Kidney, left, "solid #1" (excision): Renal cell carcinoma, papillary type I.. 6. Kidney, left, "solid #2" (excision): Renal cell carcinoma, papillary type I. 7. Kidney, left, "solid #3" (excision): Renal cell carcinoma, papillary type I. 8. Soft tissue, left perirenal, "scat tissue #4" (excision): Scar tissue and fibroadipose tissue, no tumor seen. 9. Kidney, left, "solid #5" (excision): Small focus of renal cell carcinoma, papillary type I. 10. Kidney, left "solid #6" (excision): Small focus of renal cell carcinoma, papillary type I. 11. Kidney, left "solid #7" (excision): Small focus of renal cell carcinoma, papillary type I. 12. Kidney, left "solid #8" (excision): Small focus of renal cell carcinoma, papillary type I. 13. Kidney, left "solid #9" (excision): Small focus of renal cell carcinoma, papillary type I. Patient Identification
+
+--- Page 2 ---
+14. Kidney, left "solid #10" (excision): Renal cell carcinoma, papillary type I. 15. Kidney, left "solid #11" (excision): Benign kidney parenchyma with sclerotic glomeruli and inflammation, no tumor seen. 16. Kidney, left "solid #12" (excision): Renal cell carcinoma, papillary type I. 17. Kidney, left "upper pole cyst wall #13" (excision): Cystic lesion with irregular cuboidal lining, benign kidney. parenchyma and fat, no tumor seen.. 18. Kidney, left "solid #14" (excision): Renal cell carcinoma, papillary type I. 19. Kidney, left "solid #15" (excision): Renal cell carcinoma, papillary type I. 20. Kidney, left "solid #16" (excision): Renal cell carcinoma, papillary type I. 21. Kidney, left "solid #17" (excision): Small focus of renal cell carcinoma, papillary type I. 22. Kidney, left "solid #18" (excision): Small focus of renal cell carcinoma, papillary type I.. 23. Kidney, left "solid #19" (excision): Small focus of renal cell carcinoma, papillary type I.. 24. Kidney, left "normal tissue adjacent to #19" (excision): Benign kidney parenchyma with sclerotic glomeruli and. inflammation, no tumor seen.. 25. Kidney, left "#20" (excision): Renal cell carcinoma, papillary type I. 26. Kidney, left "solid #21" (excision): Small focus of renal ceil carcinoma, papillary type I.. 27. Soft tissue, left perirenal, "perirenal fat" (excision): Adipose tissue, no tumor seen.. 28. Soft tissue, left perirenal, "perirenal fat lower pole" (excision): Adipose tissue, no tumor seen. 29. Skin, not otherwise specified (biopsy): Skin, no tumor seen.. 30. Rib, left 11th (excision): Bony fragment consistent with rib, gross diagnosis only.. Patient Identification
+
+--- Page 3 ---
+CLINICAL INFORMATION: HISTORY:RENAL TUMORS * EXAM IS RELATED TO ORDERING PROTOCOL Ordering Protocol: PROCEDURE: PREOP DX:#LEFT RENAL TUMORS POSTOP DX: SAME OPERATIVE FINDINGS: MULTIPLE LEFT RENAL LESIONS SPECIMENS SUBMITTED: 1) TUMOR, Pseudo capsule lateral (1FS) 2) FAT, Anterior perirenal (2FS) 3) FAT, Peri renal - upper pole (3FS) 4) SOFT TISSUE, NOS, Scar (4FS) 5) KIDNEY, Solid # 1 6) KIDNEY, Solid # 2 7) KIDNEY, Solid # 3 8) KIDNEY, Scar tissue 9) KlDNEY, Solid # 5 10) KlDNEY, Solid # 6 11) KIDNEY, Solid # 7 12) KlDNEY, Soild # 8 13) KlDNEY, Solid # 9 14) KlDNEY, Solid # 10 15) KIDNEY, Solid # 11 16) KIDNEY, Solid # 12 17) KIDNEY, Upper pole wall tumor # 13 18) KlDNEY, Solid # 14 19) KiDNEY, Solid # 15 20) KIDNEY, Solid # 16 21) KlDNEY, Solid # 17 22) KIDNEY, Solid # 18 23) KlDNEY, Solid # 19 24) KIDNEY, Normal tissue adjacent to # 19 25) KIDNEY, Solid # 20 26) KIDNEY, Solid # 21 27) FAT, Perirenal 28) FAT, Perirenal lower pole. 29) SKIN BIOPSY 30) RIB, 11th Ieft INTRAOPERATIVE CONSULTATION Patient Idontification
+
+--- Page 4 ---
+Frozen Section Diagnosis 1FS: Benign fibrous tissue. (Diagnosis render Frozen Section Diagnosis 2FS: Benign fibroadipose tissue.. Frozen Section Diagnosis 3FS: Benign fibroadipose tissue Frozen Section Diagnosis 4FS: Benign fibrous tissue.. GROSS DESCRIPTION: 1. Received fresh for frozen labeled with the patient's name, medical record number, and "pseudocapsule/lateral tumor" is a fragment of wispy red and tan, soft tissue measuring 1.2 x 1.2 x 0.3 cm., which is frozen in its entirety as 1FS1.. 2. Received fresh for frozen section labeled with the patient's name, medical record number, and as "anterior peri-renal fat" consists of a yellow, light/tan fragment of soft tissue measuring 2.0 x 1.2 x 0.4 cm., which is frozen in its entirety as 2FS.. 3. Received fresh for frozen section labeled with the patient's name, medica! record nurnber, and as "peri-renal fat - upper pole" consists of a single fragment of yellow fatty tissue, measuring 2.0 x 1.8 x 0.4 cm., which is frozen in its entirety as 3FS. 4. Received fresh for frozen section labeled with the patient's name, medical record number, and as "scar tissue" is a single tan/red fragment of soft tissue measuring 1.5 x 0.7 X 0.3 cm., which is frozen in is entirety as 4FS. 5. Received fresh in a single container labeled with the patient's name, medical record number, and "solid #1' is an off-white to tan nodule measuring 4 x 4 x 3 cm. Sectioning of the specimen demonstrates light tan to golden-yellow soft tissue. Portions of the specimen are procured by lab. A representative portion. of the specimen is forwarded to Surgical Pathology and is placed in a single cassette marked 6. Received fresh in a container labeled with the patient's name, medical record number, and as "solid #2" is a single tan nodule measuring 0.7 x 0.7 x 0.5 cm. A portion of the specimen is procured by lab The remainder of the specimen is placed in a single cassette marked 7. Received fresh in a single container labeled with the patient's name, medical record number, and as "solid #3" consists of two off-white fragments of soft tissue, measuring in aggregate 1.0 x 0.5 x 0.5 cm. Half of the specimen is procured by Jab. The remainder of the specimen is placed in its entirety in a single Patient Identification
+
+--- Page 5 ---
+cassette marked The specimen is placed in a biopsy bag before hand.. 8. Received fresh in a single container labeled with the patient's name, medical record number, and as "scar tissue #4" are two red fragments of soft tissue measuring in aggregate 1.0 x 0.5 x 0.3 cm. The specimen is divided and portions are given to . lab. The remainder of the specimen is forwarded to Surgical Pathology is placed in its entirety in a single cassette marked. 9. Received fresh in a single container labeled with the patient's name, medical record number, and "solid #5" are two fragments of light tan soft tissue measuring in aggregate 0.9 x 0.6 x 0.4 cm., which are placed in their entirety in a single white cassette marked. 10. Received fresh in a single container labeled with the patient's name, medical record nurnber, and as "solid #6" consists of a tan nodule of soft tissue measuring 1.5 x 1.0 x 1.0 cm. The specimen is sectioned to reveal red and gold soft tissue. Half of it is procured by. lab and the remainder of the specimen is placed in its entirety in a single cassette marked 11. Received in a single formalin-filled container labeled with the patient's name, medical record number, and as "solid #7" consists of a single light tan fragment of soft tissue measuring 0.7 x 0.5 x 0.4 cm. , which is submitted in its entirety in a white cassette marked. 12. Received fresh in a single container labeled with the patient's name, medical record number, and as "solid #8" consists of two tan fragments of soft tissue measuring in aggregate 1.0 x 1.0 x 0.6 cm. Half of the specimen is procured by. ab. The remainder of the specimen is forwarded to Surgical Pathology. is placed in a single cassette marked. 13. Received in a single formalin-filled container labeled with the patient's name, medical record number, and as "solid #9" is a single irregularly shaped fragment of light tan soft tissue measuring 1.2 x 0.5 x 0.5 cm., which. is placed in its entirety in a single cassette marked. 14. Received in a single formalin-filled container labeled with the patient's name, medial record number, and "solid #10" are multiple fragments of light tan soft tissue measuring in aggregate 0.9 x 0.4 x 0.4 cm., which are filtered through a biopsy bag and submitted in their entirety in a single cassette marked. 15. Received in a single formalin-filled container labeled with the patient's name, medical record number, and. as "solid #11" is a single irregularly shaped fragment of light tan soft tissue measuring 0.7 x 0.4 x 0.4 cm. which. is placed in its entirety in a single cassette marked. 16. Received fresh in a single container labeled with the patient's name, medical record number, and as "solid #12" are multiple fragments of light tan soft tissue, measuring in aggregate 0.4 x 0.4 x 0.2 cm, which are Patient Identification.
+
+--- Page 6 ---
+wrapped in lens paper and submitted in entirety in a single cassette marked 17. Received in a single formalin-filled container labeled with the patient's name, medical record number, and as "upper pole cyst wall #13" consists of light tan and fibrofatty soft tissue measuring in aggregate 2 x 1 x 0. cm., which are placed in their entirety in a single cassette marked 18. Received in a single formalin-filled container labeled with the patient's name, medical record number, and as "solid #14" consists of multiple fragments of light tan and gold-colored soft tissue measuring in aggregate 1.2 x 0.8 x 0.4 cm., which are filtered through a biopsy bag and subrmitted in their entirety in a single cassette marked 19. Received in a single formalin-filled container labeled with the patient's name, medical record number, and as "solid #15" is a single fragment of light tan soft tissue measuring 0.4 x 0.4 x 0.4 cm. which is wrapped in lens paper and submitted in its entirety in a single cassette marked 20. Received fresh in a single container labeled with the patient's name, medical record number, and as "solid #16" is a gold/red fragment of soft tissue measuring 5 x 5 x 4.5 cm. It is sectioned to reveal yellow-gold tumor in a nodular morphology. Some of the tumor is soft with areas of hemorrhage. Portions of the tumor are procured by Jab. The specimen is then forwarded to Surgical Pathology. A representative portion of this specimen is placed in a single white cassette marked 21. Received fresh in a single container labeled with the patient's name, medical record number, and as "solid #17" is a small tan nodule measuring 0.5 x 0.5 x 0.3 cm. A portion of the specimen is given td lab. The remainder of the specimen is forwarded to Surgical Pathology is placed in its entirety in a single cassette marked 22. Received fresh in a single container labeled with the patient's name, medical record number, and "solid #18" is a small light tan, soft tissue nodule measuring 0.5 x 0.5 x 0.5 cm. Half of the specimen is procured by lab. The remainder of the specimen is forwarded to Surgical Pathology is placed in its entirety in a single white cassette marked 23. Received fresh in a single container labeled with the patient's name, medical record number, and "solid #19" is a single light tan soft tissue nodule measuring 0.7 x 0.6 x 0.5 cm. One-half of the specimen is given to Iab. The remainder of the specimen is forwarded to Surgical Pathology is placed in its entirety in a single cassette marked 24. Received in a single formalin-filled container labeled with the patient's name, medical record number, and as "normal tissue adjacent to #19" is a single nodular fragment of light tan soft tissue measuring 1 x 0.7 x 0.4 cm., which is placed in its entirety in a single cassette marked Patient Identification
+
+--- Page 7 ---
+25. Received fresh in a single container labeled with the patient's name, medical record number, and as "#20' is a single red/brown fragment of soft tissue in a nodular shape, measuring 0.7 x 0.6 x 0.6 cm. One-half of the specimen is given to. lab. The remainder of the specimen is forwarded to Surgical Pathology is placed in its entirety in a single cassette marked 26. Received fresh in a single container labeled with the patient's name, medical record number, and as "solid #21" is a small light tan soft tissue fragment measuring 0.5 x 0.5 x 0.3 cm. One-half of the specimen is procured by lab. The remainder of the tissue is forwarded to Surgical Pathology is placed in its entirety in a single cassette marked 27. Received in a single formalin-filled container labeled with the patient's name, medical record number, and as "perirenal fat" is a single fragment of fibrofatty tissue measuring 4 x 1.5 x 0.5 cm. The specimen has areas of fibrosis along with fibrofatty tissue. The specimen is placed in its entirety in a single cassette marked 28. Received in a single formalin-filled container labeled with the patient's name, medical record number, and as "perirenal fat lower pole" consists of multiple fragments of yellow fibroadipose tissue, measuring in aggregate 2.5 x 2 x 1.0 cm. The specimen is submitted in its entirety in toto in three cassettes marked 29. Received in a saline in a single container labeled with the patient's name, medical record number, and as "skin biopsy" is an ellipse of skin measuring 2.2 X 1.0 x 0.7 cm. A fragment of the specimen is kept by Surgical Pathology and the remainder is given to lab for fibroblastic culture. That portion. forwarded to Surgical Pathology is placed in its entirety in a single cassette marked 30. Received in a single formalin-filled container labeled with the patient's name, medical record number, and "11th rib - left" is a bony fragment in a shape consistent with segment of rib. It measures 6 cm. in greatest length. The proximal end measures 1.4 x 0.5 cm. and it tapers off to a cartilaginous end. There is a small amount of fibrous tissue and skeletal muscle associated with the specimen. This specimen is described for a gross diagnosis only.. Patient Identification.
+
+--- Page 8 ---
+Patient Identification
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diff --git a/output/text/20ee9f05-9b03-41bf-8b85-178d7aaa56ae.txt b/output/text/20ee9f05-9b03-41bf-8b85-178d7aaa56ae.txt
new file mode 100644
index 0000000000000000000000000000000000000000..25c611733c1483d5b1294d9b38049c91cc601810
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1cD-0-3 c50.9 hws 3f11f1! Sits. bresot, Nus page 1 / 1 Department of Cancer Pathology copy No. Date: Examination: Histopathological examination. Internal invoice No. Cost of diagnostic procedure. Examination No.: PESEL: XXX Age: Patient: XXx Gender: F Material: 1. Multiple organ resection - left breast and axillary tissue. Unit in charge: Physician in charge: Material collected on: Material collected on:. Expected time of examination: up to 8 working days Clinical diagnosis: Status after intraoperative examination - ca invasivum.. Examination performed on:. Macroscopic description: Left breast sized 21 x 10 x 5 cm removed along with axillary tissues sized 12 x 7 x 15 cm and a 19 x 10 cm skin flap. Weight 820 g. Tumour site sized 11 x 7 x 3 cm on the boundary of outer quadrants, 2 cm from the upper boundary, 0.5 cm from the base and 1 cm from the skin. A post-operative scar visible in the outer quadrant skin with a seam of 7 cm. Metastatic lymph nodes of 2.5 cm. Microscopic description:  Invasio carcinomatosa vasorum. Infiltratio carcinomatosa mamillae.  In the tumour site, singular foci of carcinoma ductale invasivum and lesions of the type mastopathia fibrosa et cystica, hyperplasia ductalis simplex (UDH) AXILLARY LYMPH NODES Metastases carcinomatosae in lymphonodis No IV/xI. Infiltratio capsulae lymphonodorum. Histpathological diagnosis:.  Carcinoma ductale partim micropapillare invasivum mammae sinistrae. Invasive ductal carcinoma partially micropapillary of the left breast.  Metastases carcinomatosae in lymphonodis axillae (No IV/xi) (NHG2, pT2, pN2a). Cancer metastases in axillary lymph nodes (No (v/xI)  Invasio carcinoma vasorum. Vascular invasion. Compliance validated by: UUID:B4DB830F-BFA4-47F5-94C7-D95984315866 Redacted
\ No newline at end of file
diff --git a/output/text/2129b182-b42c-4cfe-9366-1cc23c9163a6.txt b/output/text/2129b182-b42c-4cfe-9366-1cc23c9163a6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6362b74880cf3f71dc0ef20833efc967d645a3ab
--- /dev/null
+++ b/output/text/2129b182-b42c-4cfe-9366-1cc23c9163a6.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+PsH- Sih: Breast, lppw outwqusdrert c50.4 CQcF- Braot, Nos C50.9 1201 Procedure Date: Procedure Physician: ase is [circle Attending Physician/Copies To: .UALISIED CISCUALIFIED UUID:E2EE2397-0F8A-4A71-983C-0007F7D00500 PatIent hIstory: TCGA-BH-A1F0-01A-PR Redacted + DaTe of LMp: * DATE OF LAST DELIVERY: PRE-OP DIAGNOSIS: L BREAST CA POST-OP DIAGNOSIS: SAME OPERATIVE PROCEDURR: LEFT TOTAL MASTECTOMY, LEFT AXILLARY SAMPLING CLINICAL HISTORY: * MATERIAL SUEAITTAD: LEFT (MOD) RADICAL MASTECTOMY, PROCUREMENT BY SURGICAL PROCEDURE INTRAOPERATIVE CONSULTATION: Left breast with axillary sampling. Mass identified at 1:00 position, 2.0 by 2.0 by 2.0 cm. Second lesion, just lateral to first, 1.s by 1.5 by l.0 cm. Surgical margins grossly free for both tumors. Axillary tail containing fatty lymph node with blue coloration (treat as sentinel node). REVISEDRERORT -IAGNOSIS: - **OUTER** QUADRANT **MULTIFOCAL** IN UPPER - SIZk-OF THE FOCI ARE 2.0 BY 2.0 BY 2.0 **AND++ 1.5 aY 1.5 BY 1.0 CX **DOTH** TUMORS HAVE IDENTICAL MORPHOLOGY - NOTTINGHAM SCORE-8 (TUBULES-3, NUCLEAR ATYPIA-3, MITOSIS-2) ALL SURGICAL MARGINS FREE OF TUMOR - NIRPLE AND AREOLA WITH NO DIAGNOSTIC CHANGES NON-NEOPLASTIC BRZAST WITH NO DIAGNOSTIC CHANGRS ONE (1) LYMPH NODE (SENTINEL); POSITIVE FOR METASTATIC CARCINCMA (1/9) NOTe: The micrometastasis msasures 1.5 mm and was identiried both on Hce and immunoparoxidase stain. AJCC stage Tic Nla Mx. ++The two tumor nodulos are located in upper outer quadrant. The tumor adjacent to the nipple mantioned in the previous report, is part of one of the two tumor nodules.*+ er/pr immunoperoxidas. assay and Her-2/nxu testing will be performed on block "A2". ** REVISION (GROSS DESCRIPTION) Addendum MATERIAL SUBMITTED: BLOCK "A2" AND "A4" FOR ER/PR AND HER-2/NEU FINAL DIAGNOSIS: ER/PR RESULTS ("A2") IMMUNOPEROXIDASE IDENTIFICATION OF ESTROGEN AND PROGESTERONE RECEPTORS IS CARRIED OUT ON SLIDE "A2". DISTINCT INTRANUCLEAR STAINING IS IDENTIFIKD FOCALLY FOR PROGESTERONE RECEPTOR (1St) BUT NOT FOR ESTROGEN RECEPTOR. THERETORE, PROGESTERONE RECEPTOR IS INTERPRETED AS BORDERLINE AND ESTROGEN RECEPTOR AS NEGATIYE. HER-2/NEU RESULTS ("A2") AS PER THE REQUEST OF DR. . C-erbB2 (HER-2/NEU) IMUNOSTAINING IS CARRI5D OUT ON PREVIOUS MAGRE SURGICAL S (BREAST CANCER) USING A 1:3OO DILUTICN OF DAKO'S POLXCLONAL ANTIBODY AAQ5 (DIRECTED AGAINST THE INTRACELLULAR DOMAIN OF C-OrbB2) WITHOUT ANTIGEN RETRIEVAL. NO DISTINCT COMPLETES BR/PR RESULTSS"AS") IMMUNOPEROXIDASE IDENTIFICATION Or BSTROGEN AND PROGESTERONE RECEPTORS IS CARRIED OUT ON SLIDE "A4". DISTINCT INTRANUCLEAR STAINING IS IDENTIFIED FOCALLY FOR PROCESTGERONE RECEPTOR (1St) BUT NOT FOR BSTROGEN RECEPTOR. THERETORE, PROGKSTERONE RECEPTOR IS INTERPRETED AS BORDERLINE AND ESTROCEN RECEPTOR AS NEGATIVE. HER-2/NSU RESULTS A4" AS PER THE REQUEST OF DR. . C-erbB2 (HER-2/NEU) IMANOSTAINING I8 CARRIED OUT ON PREVICUS MAGEB SM (AREAST CANCER) USING A 1:3OO DILUTION OF DAKO'S POLYCLONAL ANTIBODY A485 (DIRECTED AGAINST THE^INTRACELLULAR DOMAIN OF c-erbB2) WITHOUT ANTIGEN RETRIEVAL. NO DISTINCT COCPLETE MEMBRANE STAINING IS IDENTIFIED. THEREFORS, C-erbB2 (HER-2/NEU) IS INTERPRETSD AS NEGATIVE. (SCORE 0).
\ No newline at end of file
diff --git a/output/text/212e32f9-5788-4c80-8a7b-e8389dea7b8a.txt b/output/text/212e32f9-5788-4c80-8a7b-e8389dea7b8a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8a81b1565cf895596f2b6d4fe26ed938e5e9d0e9
--- /dev/null
+++ b/output/text/212e32f9-5788-4c80-8a7b-e8389dea7b8a.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: FMP/SSN: DOb/Age/Sex: (Age: )F Race: WHITE Taken: Location: Received: Physician(s) : Reported: /cs-0-3 SPECIMEN: Cavci omr, mnfi/tnuthy 1obule,Nos 8520/3 A: LEFT BREAST B: RIGHT BREAST 8ifu: brest N0S C: LEFT AXILLARY SENTINEL NODE C 50.9 D: RIGHT AXILLARY SENTINEL NODE 112l/u h E: RIGHT AXILLARY NON SENTINEL NODE FINAL DIAGNOSIS: A. BREAST, LEFT, SIMPLE MASTECTOMY:  SKIN WITH NO SIGNIFICANT PATHOLOGIC CHANGES. BREAST TISSUE WITH FIBROCYSTIC CHANGES TO INCLUDE APOCRINE METAPLASIA AND MICROCYST FORMATION.  NEGATIVE FOR MALIGNANCY. B. BREAST, RIGHT, SIMPLE MASTECTOMY: - TUMOR TYPE: INVASIVE LOBULAR CARCINOMA, MULTICENTRIC (SEE COMMENT) . TUMOR #1: TUMOR TYPE: INVASIVE LOBULAR CARCINOMA, LOW NUCLEAR GRADE.  NOTTINGHAM GRADE: I/III NOTTINGHAM SCORE: 5/9 (Tubules- 3, Nuclei- 1, Mitoses- 1; mitotic count 1 per 10 HPF at 40x power) . TUMOR LOCATION: LOWER OUTER QUADRANT. TUMOR SIZE (GREATEST DIMENSION): 1.O CM (MEASURED GROSSLY).  ADDITIONAL DIMENSIONS: 1.0 X 0.5 CM. TUMOR NECROSIS: NONE IDENTIFIED.  MICROCALCIFICATIONS: NONE IDENTIFIED.  VENOUS / LYMPHATIC INVASION: NONE IDENTIFIED.  MARGINS: TUMOR INVOLVES INKED SUPERFICIAL MARGIN (B2). INTRADUCTAL COMPONENT: NONE IDENTIFIED.  LYMPH NODES: FOUR (4) OF FOUR POSITIVE FOR TUMOR BY H&E (SEE PARTS D) AND E). -NIPPLE INVOLVEMENT: NOT IDENTIFIED. -SKIN INVOLVEMENT: NOT IDENTIFIED. TUMOR #2:  TUMOR TYPE: INVASIVE LOBULAR CARCINOMA, LOW NUCLEAR GRADE.  NOTTINGHAM GRADE: I/III NOTTINGHAM SCORE: 5/9 (Tubules- 3, Nuclei= 1, Mitoses= 1; mitotic count 2 per 10 HpF at. UUID:2620E5E7-ED7D-4F04-A8AF-1499E9711E8A Redacted Page 1 TCGA-A2-A0EW-01A-PR Continued on Next Page. - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 2 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: FINAL DIAGNOSIS (continued): 40x power). TUMOR LOCATION: UPPER MIDDLE. TUMOR SIZE (GREATEST DIMENSION): 1.O CM (MEASURED GROSSLY) (SEE COMMENT). ADDITIONAL DIMENSIONS: 1.0 X 0.5 CM.  TUMOR NECROSIS: NONE IDENTIFIED.  MICROCALCIFICATIONS: PRESENT, ASSOCIATED WITH LOBULAR CARCINOMA IN SITU (B3).  VENOUS / LYMPHATIC INVASION: NONE IDENTIFIED.  MARGINS: TUMOR <O.1 CM FROM INKED SUPERFICIAL MARGIN (B3).  INTRADUCTAL COMPONENT: NONE IDENTIFIED. LYMPH NODES: SEE ABOVE.  NIPPLE INVOLVEMENT: NOT IDENTIFIED. SKIN INVOLVEMENT: NOT IDENTIFIED. ESTROGEN RECEPTORS: POSITIVE (PER) PROGESTERONE RECEPTORS: POSITIVE (PER HER 2 NEU by IHC: 1+ (NEGATIVE) (PER PATHOLOGIC STAGE: pTlc N2 MX (AJCC, 6th ED) (SEE COMMENT) . ADDITIONAL PATHOLOGIC CHANGES: LOBULAR CARCINOMA IN SITU. ACELLULAR FOREIGN MATERIAL AND BIOPSY SITE CHANGES (SEE COMMENT). FIBROCYSTIC CHANGES TO INCLUDE APOCRINE METAPLASIA AND MICROCYST FORMATION. MAMMARY DUCT ECTASIA. C. SENTINEL LYMPH NODE, LEFT AXILLA, EXCISIONAL BIOPSY: THREE (3) BENIGN LYMPH NODES BY CONVENTIONAL H&E AND IMMUNOHISTOCHEMICAL STAINING. D. SENTINEL LYMPH NODES, RIGHT AXILLA, EXCISIONAL BIOPSY: THREE (3) LYMPH NODES POSITIVE FOR CARCINOMA BY CONVENTIONAL H&E AND IMMUNOHISTOCHEMICAL STAINING. E. NON-SENTINEL LYMPH NODE, RIGHT AXILLA, EXCISIONAL BIOPSY: ONE (1) LYMPH NODE POSITIVE FOR CARCINOMA WITH EXTRACAPSULAR EXTENSION BY H&E STAINING. Comment: There are two separate tumors in the right breast mastectomy. specimen. Since these tumors are separated by 4.5 cm and are located in different quadrants the designation "multicentric" is used. Both tumors. are histologically similar. The acellular marker material present in the specimen is associated with the upper middle tumor (tumor #2). There are isolated tumor cells present in a section adjacent to the upper middle. Page 2 Continued on Next Page. FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 3 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA -  PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: FINAL DIAGNOSIS (continued): tumor (tumor #2, slide B4), making the exact determination of tumor size difficult. The largest dimension measured of the tumor is 1.2 cm from the previous biopsy specimen (s08-. ,'', making the tumor stage Tlc. The histologic appearance along with the presence of lobular carcinoma in situ and the immunohistochemical characterization of the previous biopsy support the diagnosis of invasive lobular carcinoma. **  Report Electronically Signed Out * CLINICAL DIAGNOSIS AND HISTORY: year-old female with right breast mass birads four on mammogram, ultrasound guided biopsy, invasive lobular carcinoma. Bilateral simple mastectomy, skin biopsy, with immediate reconstruction. PRE-OPERATIVE DIAGNOSIS: Right breast cancer. GROSS DESCRIPTION: A. Received fresh, labeled with the patient's name, designated "LEFT BREAST TISSUE WITH MARKINGS" is a mastectomy specimen oriented with a short stitch superior, long stitch lateral, and double stitch "down".  The specimen measures 17.0 cm medial to lateral, 16 cm superior to inferior, and 3.5 cm anterior to posterior. The lightly pigmented superficial skin ellipse measures 10.0 x 3.0 cm and displays a 1.0 cm centrally located everted nipple free of discharge. No scar is identified. The deep margin is inked black. Serial sections reveal predominantly lobulated, yellow-tan, adipose tissue admixed with evenly distributed, tan-white, fibrous tissue comprising approximately 20% of the cut surface. On palpation, no discreet mass or lesion is identified. No lymph nodes are identified.. Cassette Summary: Al: Skin. A2: Upper outer quadrant. A3: Upper inner quadrant. A4: Lower inner quadrant. A5: Lower outer quadrant. A6: Central. A7: Nipple. A8: Upper outer quadrant. Page 3 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 4 ---
+FOR ORFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DEsCRIpTION (continued) : A9: Upper inner quadrant. Ai0: Lower inner quadrant. All: Lower outer quadrant. Matched sections of Al through A6 are submitted in. : for cbcp protocol. B. Received fresh, labeled with the patient's name,. designated "RIGHT BREAST TISSUE WITH MARKINGS" is a mastectomy specimen oriented with a short stitch superior, and a long stitch lateral. The specimen measures 7.0 cm superior to inferior, 17.0 cm medial to lateral,. and 3.5 cm anterior to posterior. The lightly pigmented superficial skin ellipse measures 10.0 x 3.0 cm and displays a 1.0 cm centrally located, everted nipple free of discharge. No scar is identified. The deep margin. is inked black, and the superficial surface is partially inked blue. Serial sections reveal a 1.0 x 1.0 x 0.5 cm well defined, tan-white mass in the upper mid breast, abutting the blue inked superficial surface, and coming to within 4.0 cm of the deep margin. Also identified is a second, poorly defined mass in the lower outer quadrant measuring approximately 1.0 x 1.0 x 0.5 cm. The lower outer quadrant mass abuts the blue inked superficial surface, and is located 4.5 cm from the deep margin. The. masses are separated by a distance of approximately 4.5 cm.. The remainder of the specimen is predominantly composed of lobulated, yellow-tan, adipose tissue admixed with approximately 20% slightly dense, fibrous tissue.  No additional lesions are identified. No lymph nodes are. identified. Cassette Summary: Bl: Skin. B2: Lower outer quadrant mass. B3: Upper mid mass. B4: Adjacent normal (to B3). B5: Upper outer quadrant. B6: Lower outer quadrant. B7: Lower inner quadrant. B8: Upper inner quadrant. B9: Nipple. B10: Lower outer quadrant mass.. Bil: Deep margin of lower outer quadrant mass.. B12-B13: Upper mid mass. Bl4: Deep margin of upper mid mass.. c. Received in formalin, labeled with the patient's name,. D, designated "LEFT AXILLARY SENTINEL NODE" is a 5.5 x 4.5 x 0.6 cm irregularly shaped, lobulated fragment of tan-yellow, adipose. Sectioning Page 4 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974E
+
+--- Page 5 ---
+FOR OFFICIAL USK ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION (continued): reveals three possible lymph nodes ranging in size from 1.0 x 0.6 x 0.3 cm to 1.2 x 1.0 x 0.6 cm. The lymph nodes are bisected, and submitted in cassettes C1 through c3.. D. Received in formalin, labeled with the patient's name,. D, designated "RIGHT SENTINEL NODe" is a tan-yellow, lobulated, irregularly shaped fragment of adipose tissue measuring 5.5 x 3.0 x 0.5 cm in diameter. Examination reveals three possible lymph nodes ranging in size from 0.2 x 0.2 x 0.2 cm to 2.3 x 1.6 x 1.0 cm. Cassette Summary: D1-D2: First possible lymph node. D3: Second possible lymph node.. D4: Third possible lymph node.. E. Received fresh for intraoperative consultation, labeled with the patient's name, ,designated "RIGHT AXILLARy TISSUE, NON SENTIneL NoDE" is a 4.0 x 3.5 x 2.0 cm irregular portion of yellow-tan, soft tissue. Sectioning reveals a single, 1.5 x 1.0 x 0.5 cm lymph node. The cut surface is tan-white, suspicious for involvement by lesion. The lymph node is bisected, and submitted in cassette El. A matched section of El is submitted in - .or cBcp protocol. Time in formalin for specimen A: 79 hours. Time in formalin for specimen B: 81 hours.. Page 5 End of Report FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
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diff --git a/output/text/214eb83c-3dc8-414b-9b20-0ee4adf4412b.txt b/output/text/214eb83c-3dc8-414b-9b20-0ee4adf4412b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e932945dda97f9a4cf3a6cad6f18828cce4095b3
--- /dev/null
+++ b/output/text/214eb83c-3dc8-414b-9b20-0ee4adf4412b.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+UUID:FAB79463-7351-4C25-9AEC-7B47486C7F54 TCGA-4T-AA8H-01A-PR Redacted Results Surgical Pathology TOD O3 Result Data ACCESSION Site: Cwecenolirg colon C18.6 Q i|13|i4 Entry Date Component Results Component Lab Clinical History Malignant neoplasm of sigmoid colon.. Gross Examination A. "Left paratubal cyst with left tubal fimbria". Received fresh and placed. in formalin atj is a 1.5 x 1.5 x 1.0 cm fragment of fimbria with attached 3.5 x 3.0 3.0 cm paratubal cyst. The cyst is unilocular and filled with clear serous fluid. The cyst wall is less than 0.1 cm thick and has a smooth internal lining. Representative sections are submitted as follows: BLOCK SUMMARY: A1- fimbriated end, bisected A2- representative sections of cyst wall. A3-9 remainder of specimen B. "Descending and siqmoid colon, stitch marks distal". received and placed in formalin on Specimen received: Descending colon and sigmoid colon. Colon length: 21.5 cm. Tumor location: Descending colon. Tumor dimensions: 5.2 x 4.7 x 1.2 cm Tumor appearance: Exophytic, lobulated, and focally friable. On cut surface, the mass displays elongated cystic spaces within. the bowel wall which are filled with friable tumor material. Distance from margins: Proximal: 2.8 cm. Distal: 13.5 cm. Mesenteric: 2.0 cm. Bowel circumference at tumor site: 7.2 cm. -  growth: 75%. Depth of invasion: 2.2 cm. Deepest invasion: The mass invades through the bowel wall, into the fat and. puckers the underlying serosa (inked blue). Tumor perforation: No. Involvement of adjacent structures: No. Mesentery dimensions: 20.0 x 7.0 x 2.0 cm Serosa: The serosa is focally puckered underlying the mass (blue ink). The puckering comes within 3.5 cm of the proximal margin. Lymph nodes: Multiple lymph nodes are identified, up to 1.0 cm in greatest dimension. Page I of 4
+
+--- Page 2 ---
+Secondary findings: The remainder of the bowel mucosa is tan, velvety, with normal folding pattern. There is focal submucosal tattooing, 2.5 cm proximal to the mass. Special studies prospectively ordered: No Yes. Photograph: Block diagram: No. Tissue submitted for research: Yes, tumor and normal. BLOCK SUMMARY: B1-B2- proximal margin B3-B4- distal margin B5- mass, deepest invasion with serosal puckering B6-B10- additional sections of mass B11- mass to closest mesenteric margin B12- representative normal colon with tattoo. B13- six lymph nodes B14 six lymph nodes B15- four lymph nodes B16-- four lymph nodes B17- four lymph nodes B18- four lymph nodes B19- one lymph node, bisected. B20- one lymph node bisected Microscopic Examination Microscopic examination is performed. Within part A, the fallopian tube fimbria demonstrates a focal area of mild cytologic atypia. Immunohistochemistry of this area (block Al) reveals weak/low cytokeratin 7, p53 and Ki67 expression. Cytokeratin 20, Pax8 and cdx2 are negative. In comparison, the tumor present in the colon demonstrates strong cytokeratin 20 and cbx2 expression and is negative for Pax8, p53, and cytokeratin 7. Ki67 is moderately elevated. Overall, the findings in the fallopian tube are felt to be secondary to cautery artifact. Dr.. has reviewed parts of this case. and concurs with the interpretation.. Immunohistochemical Findings The immunoperoxidase tests reported herein were developed and their performance characteristics were determined by the Some of them may not be cleared or approvea by the U.s. Food and Drug Aaministration.. The FDA has determined that such. clearance or approval is not necessary. These tests are used for clinical. purposes. They should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLiA) as qualified to perform high complexity clinical. testing. Pathologic Stage PATHOLOGIC STAGE (AJCC 7th Edition): pT3 pNO pMX NOTE: Information on pathology stage and the operative procedure is transmitted to this Institution's Cancer Registry as required for accreditation by the Commission on Cancer. Pathology stage is based solely upon the current tissue specimen being evaluated, and does not incorporate information on any specimens submitted separately to our Cytology section, past pathology information, imaging studies, or clinical or operative findings. Pathology stage is only a component to be considered in determining the clinical stage, and should not be confused with nor substituted for it.  Page 2 of 4
+
+--- Page 3 ---
+The exact operative procedure is available in the'surgeon's operative report. Diagnosis A. LEET FALLOPIAN TUBE FIMBRIA AND PARATUBAL CYST, EXCISION:S BENIGN PARATUBAL CYST. B. DESCENDING AND SIGMOID COLON, RESECTION: INVASIVE ADENOCARCINOMA OF THE LEFT COLON. Histologic type: MUCINOUS ADENOCARCINOMA. Histologic Grade: LOW GRADE. Tumor size: 5.2 x 4.7 x 1.2 CM. Extent of invasion: TUMOR INVADES THROUGH THE MUSCULARIS PROPRIA INTO THE PERICOLONIC ADIPOSE TISSUE.S Macroscopic Tumor Perforation: NOT IDENTIFIED. Margins: NEGATIVE. - Closest Margin: MESENTERIC, 2.0 CM.. Lymphovascular Invasion: NOT IDENTIFIED. Perineural Invasion: NOT IDENTIFIED. Tumor Deposits: NOT IDENTIFIED. Tumor Infiltrating Lymphocytes: ABSENT. Marked Crohn's-like Lymphocytic Response:. PRESENT. Regional Lymph Nodes: TWENTY-FOUR LYMPH NODES, NEGATIVE FOR MALIGNANCY (0/24). Additional Findings TATTOO INK IS PRESENT. NOTE: MsI and/or mismatch repair protein IHC testing will be reported separately (paraffin block B6).. Comment: I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es).. M.D. Electronically signed: Testing Performed By Lab - Abbreviation Name Director Address Valid Date Range Lab and Collection  Surgical Pathology on Result Information Abnormality Status Priority Source Final result Routine Authorizing Provider Information. Name: Fax: MD Phone: Pager: Surgical Pathology (Order Authorizing: MD Date  Pathology and Cytology Department General Released By: Order: Surgery Order Information Order Date/Time Release Date/Time Start Date/Time End Date/Time  Page 3 of 4
+
+--- Page 4 ---
+Order Details Frequency Duration Priority Once 1 occurrence Routine Encounter View Encounter Reprint Requisition. Surgical Pathology (Order# Original Order Ordered On OrderedB Collection Information Collection Date Resultina Aaency Order Provider Info. Office phone Pager/beeper E mail Ordering User Authorizing Provider. 4D Order-Level Documents: There are no order-level documents. No order transmittal information available. Order may not have completed order transmittal. lw1|8|n4 V
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diff --git a/output/text/21776c2b-5f91-43f8-833d-a8839bd5dbfe.txt b/output/text/21776c2b-5f91-43f8-833d-a8839bd5dbfe.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4d78d7313fb5612dd16a2da47ec1933778c6c009
--- /dev/null
+++ b/output/text/21776c2b-5f91-43f8-833d-a8839bd5dbfe.txt
@@ -0,0 +1,24 @@
+
+--- Page 1 ---
+ced-o-3 Surgical Pathology: 0dercmo 8Q62|3 UUID:DCBDBBD7-E408-4E5F-AF2B-95F4D01C7D5C TCGA-QG-A5YV-01A-PR Redacted Site: Sigmsid aolsn C18.7 OJI s/16/13 SURGICAL PATHOLOGY Accession #: ADDENDUM Addendum Comment The purpose of this addendum is to report results following deeper levels and an immunohistochemistry stain for Pancytokeratin on a lymph node in section G35 due to a small fibrotic focus seen on the routinely stained slide. No metastatic carcinoma is seen in the additional deeper levels of the lymph node in section G35. An immunohistochemistry stain for Pancytokeratin is negative; the control is appropriate. The diagnoses remain unchanged.. This immunohistochemistry test(s) was developed and its performance characteristics determined by the Immunohistochemistry Laboratory and/or affiliated institution. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This test is used for clinical purposes. It should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA) as qualified to perform high complexity clinical laboratory testing. End of Addendum Report or Additional Results. Staff Pathologist. PATHOLOGIC DIAGNOSIS A. SOFT TISSUE, LEFT ABDOMINAL WALL, EXCISIONAL BIOPSY: - NO ADENOCARCINOMA FOUND - EXTENSIVE FIBROSIS WITH CHRONIC INFLAMMATION INVOLVING
+
+--- Page 2 ---
+LOBULES OF ADIPOSE TISSUE COMPATIBLE WITH SCAR B. URINARY BLADDER, LEFT MUCOSAL MARGIN, EXCISION: - NO ADENOCARCINOMA FOUND - UROTHELIAL MUCOSA WITH EDEMA, FOCAL HEMORRHAGE AND CHRONIC INFLAMMATION C. URINARY BLADDER, POSTERIOR MUCOSA, EXCISION: - NO ADENOCARCINOMA FOUND - UROTHELIAL-TYPE MUCOSA WITH EDEMA, CHRONIC INFLAMMATION AND HEMORRHAGE D. URINARY BLADDER, RIGHT MARGIN AND MUCOSA, EXCISION: - NO ADENOCARCINOMA FOUND - UROTHELIAL-TYPE MUCOSA WITH EDEMA, CHRONIC INFLAMMATION AND FOCAL HEMORRHAGE E. URINARY BLADDER, POSTERIOR MUSCLE MARGIN, EXCISION: - NO ADENOCARCINOMA SEEN - SMOOTH MUSCLE FIBERS WITHIN AN EDEMATOUS, INFLAMED STROMA, COMPATIBLE WITH BLADDER WALL F. SOFT TISSUE, UMBILICAL REGION, HERNIORRHAPHY: - NO ADENOCARCINOMA SEEN - COMPATIBLE WITH HERNIA SAC G. SIGMOID COLON AND URINARY BLADDER, PARTIAL CYSTECTOMY AND SIGMOIDECTOMY EN BLOC RESECTION OF DOME OF UNINARY BLADDER AND POSTERIOR ABDOMINAL WALL: - ADENOCARCIOMA, MODERATELY DIFFERENTIATED, ARISING IN A TUBULOVILLOUS ADENOMA - SPECIMEN LENGTH: 31.0 CM - TUMOR SITE: SIGMOID COLON - TUMOR SIZE: GREATEST DIMENSION: 9.5 CM - ADDITIONAL DIMENSIONS: 7.0 X 6.0 CM - MACROSCOPIC TUMOR PERFORATION: CANNOT BE DETERMINED - MICROSCOPIC TUMOR PERFORATION: PRESENT - HISTOLOGIC GRADE: LOW-GRADE - MICROSCOPIC TUMOR EXTENSION: TUMOR PENETRATES TO THE SURFACE OF THE VISCERAL PERITONEUM (SEROSA) AND DIRECTLY INVADES ADJACENT STRUCTURES (URINARY BLADDER) - MARGINS: DISTAL AND PROXIMAL MARGINS NEGATIVE - TREATMENT EFFECT: NO PRIOR TREATMENT - LYMPHOVASCULAR INVASION: NOT IDENTIFIED - PERINEURAL INVASION: NOT IDENTIFIED - TUMOR DEPOSITS (DISCONTINUOUS EXTRAMURAL EXTENSION): NOT IDENTIFIED
+
+--- Page 3 ---
+- METASTATIC ADENOCARCINOMA FOUND IN ONE OF THIRTY-ONE LYMPH NODES (1/31) - ADDITIONAL FINDINGS: - EXTENSIVE SEROSITIS, INCLUDING RESECTION MARGINS - INTRAMURAL ABSCESS - HEMORRHAGIC CYSTITISE - TUBULOVILLOUS ADENOMATOUS CHANGE - ANCILLARY STUDIES: NEGATIVE FOR MICROSATELLITE INSTABILITY (SEE PREVIOUS SURGICAL REPORT H. SIGMOID COLON, NEW PROXIMAL MARGIN, EXCISION: - NEGATIVE FOR ADENOCARCINOMA I. SIGMOID COLON, NEW DISTAL MARGIN, EXCISION: - NEGATIVE FOR ADENOCARCINOMA - ACUTE SEROSITIS J. LYMPH NODE, SITE NOT SPECIFIED, REGIONAL DISSECTION: - TWO LYMPH NODES IDENTIFIED, BOTH NEGATIVE FOR METASTATIC ADENOCARCINOMA (0/2) PATHOLOGIC STAGING (pTNM): - PRIMARY TUMOR (pT): pT4b, TUMOR DIRECTLY INVADES OR IS ADHERENT TO OTHER ORGANS OR STRUCTURES - REGIONAL LYMPH NODES (pN): pN1a, METASTASIS IN ONE REGIONAL LYMPH NODE (SEE COMMENT) NUMBER EXAMINED: THIRTY-THREE (33) NUMBER INVOLVED: ONE (1) - DISTANT METASTASIS: NOT APPLICABLE Staff Pathologist Comment Part G: A lymph node in section G35 contains a small suspicious fibrotic focus underlying the subcapsular sinus. Additional deeper levels are pending as well as a Pancytokeratin immunohistochemistry stain. These results will be issued in an addendum report.. Intraoperative Consultation. Intraoperative Frozen Section Diagnosis. FSA1-2: Soft tissue, left abdominal wall, excisional biopsy:
+
+--- Page 4 ---
+- Scarring and inflammation. - No metastatic carcinoma seen - The diagnosis was verbally reported to FSB: Urinary bladder, left mucosal margin, excision: - No malignancy seen FSC: Urinary bladder, posterior mucosa, excision: - No malignancy seen FSD: Urinary bladder, right mucosa margin, excision:. - No malignancy seen. FSE: Urinary bladder, posterior muscle margin, excision: - No malignancy seen verbally notitied of the diagnosis at. Staff Pathologist Pathology Resident Pertinent Clinical Information Possible abdominal wall involvement by sigmoid colon carcinoma. Gross Description Specimen Material: A- Left abdominal wall, B- Left bladder mucosa margin, C- Posterior bladder mucosa, D- Right bladder margin bladder mucosa, E- Posterior bladder muscle margin, F- Hernia sac, G- Sigmoid colon and. partial bladder, H- New proximal margin (sigmoid), I- New distal margin (sigmoid), J- Additional lymph node.. The case is received in ten parts, each labeled with the patient's name. medical record number and given accession number  and it is accompanied by a requisition form labeled with the same name and accession number.. Part A: Received fresh for intraoperative consultation labeled "RULE OUT TUMOR LEFT ABDOMINAL WALL" is a 2.5 x 2.0 x 0.7 cm tan-pink, irregular, soft piece of tissue which is bisected to reveal a tan-white, homogeneous area grossly compatible with either fibrous tissue or tumoral implant. Touch preparations are performed and the entire specimen is submitted for frozen section in cassettes FSA1 and FSA2. Part B: Received fresh for intraoperative consultation labeled "BLADDER LEFT MARGIN, BLADDER MUCOSA" is a 2.0 x 0.7 x 0.5 cm tan-pink to red, irregular piece of soft tissue which is entirely submitted for frozen.
+
+--- Page 5 ---
+section in cassette FSB Part C: Received fresh for intraoperative consultation labeled "BLADDER POSTERIOR, BLADDER MUCOSA" is a 2.0 x 0.7 x 0.5 cm tan-pink to red, irregular soft piece of tissue which is entirely submitted for frozen section in cassette FSC. Part D: Received fresh for intraoperative consultation labeled "BLADDER RIGHT MARGIN, BLADDER MUCOSA" is a 2.2 x 0.5 x 0.3 cm tan-pink to red, irregular soft piece of tissue which is entirely submitted for frozen section in cassette FSD. Part E: Received fresh for intraoperative consultation labeled "BLADDER MUSCLE MARGIN, FROZEN SECTION" and consists of a 2.0 x 1.1 x 0.3 cm tan-pink to red, irregular piece of soft tissue which is entirely submitted for frozen section in cassette FSE Pathology Resident Part F: Received in formalin labeled "HERNIA SAC" is a 6.0 x 6.0 x 3.5 cm tan-yellow, lobulated portion of adipose tissue with an attached fibrous membrane focally adherent to fat. The specimen is serially sectioned to reveal tan-yellow, lobulated and glistening adipose tissue with no grossly identifiable lesions. One representative section is submitted in cassette F. Part G: Received in formalin labeled "SIGMOID COLON AND PARTIAL BLADDER" is a 31.0 cm in length and a diameter ranging from 5.0 to 6.5 cm segment of colon marked with a stitch indicating the proximal end, as oriented by the. surgeon, with an attached 11.0 x 10.5 x 8.0 cm firm, round mass, displaying a 5.0 x 4.5 cm ovoid, hemorrhagic, irregular area most likely compatible. with bladder mucosal resection margin (previously sent for frozen) located towards the distal colonic end. The specimen has an attached 28.0 x 19.0 x 1.5 cm portion of mesenteric fat.. The colonic serosa is tan-gray and granular adjacent to the bladder attachment site. Additionally there are multiple inconspicuous, thin,. irregular foci of possible fibrin deposition disseminated all over the specimen. The mass has minimally attached adipose tissue with focal tan-gray granular areas of possible fibrin deposition.. There is a 9.5 x 6.0 cm tan-pink, focally friable, exophytic tumor involving the colonic mucosa circumferentially with focal areas of superficial necrosis and hemorrhage, located at 3.5 cm from the distal resection margin and at 15.0 cm from the proximal resection margin. A perpendicular section. through the mass reveals continuity with the circumferential colonic mass.
+
+--- Page 6 ---
+extending through a thick muscular wall, having up to 1.9 cm in thickness. This wall likely represents urinary bladder wall. The bulk mass of tumor. present outside the colon measures 9.5 x 7.0 x 6.0 cm. The mass is grossly extending through the entire colonic wall thickness minimally penetrating grossly into the pericolonic adipose tissue, at 0.5 cm from the serosal lining. The tumor infiltrates the muscular wall, at 1.5 cm from the bladder mucosal margin and at 0.4 cm from the outer bladder wall surface (purple ink) towards the proximal colon end Blue previous bladder resection site. Purple external mass Black mesenteric serosa at the closest point of invasion Section Code: G1: distal resection margin, en face. G2-3: proximal resection margin, en face G4-6: suspicious area of extension at superior aspect of mass adjacent to colon proximally. G7: deepest area of invasion into the mesenteric fat. G8: tumor invading the pericolonic adipose tissue G9: tumor with adjacent uninvolved mucosa at the distal end with underlying soft tissue abscess G10: possible lymph node G11-G16: representative sections of the previous bladder resection margin (perpendicular sections grossly uninvolved) G17-G20: representative sections of tumor at the colonic location G21-G22: colonic mucosa adjacent to tumor toward the proximal end G23-G25: tumor in relation to the bladder wall. G26-G27: multiple whole possible lymph nodes. G28-G29: one serially sectioned possible lymph node G30: one bisected lymph node G31: multiple whole possible lymph nodes. G32: multiple whole possible lymph nodes. G33: one bisected lymph node G34: multiple whole possible lymph nodes G35: one bisected lymph node G36: multiple whole possible lymph nodes. G37: one trisected lymph node G38: one possible bisected lymph node G39: multiple whole possible lymph nodes. G40-41: transition of tumor to bladder mucosa (orange ink towards the bladder) G42-51: bladder mucosa (posterior portion towards the distal aspect of the colon) G52-62: anterior aspect of the bladder mucosa (concluding submission of the bladder mucosa in its entirety). G63-G68: bladder wall in relation with tumor and possible skeletal muscle G69: tumor (orange indicates colonic luminal aspect)
+
+--- Page 7 ---
+G70-G73: tumor G74: one bisected lymph node G75: one bisected lymph node G76: three possible whole lymph nodes Part H: Received in formalin labeled "NEW PROXIMAL MARGIN (SIGMOID)" is a 5.0 x 0.8 x 0.7 cm portion of stapled fibroadipose tissue partially surfaced. by mucosa, compatible with colonic origin. The staple line is removed and. the remainder of the specimen is entirely submitted in a single cassette. Part I: Received in formalin labeled "NEW DISTAL MARGIN (SIGMOID)" is a 3.1 x 0.7 x 0.7 cm stapled fragment of colonic mucosa. The staple line is removed and the remainder of the specimen is submitted in cassette I. Part J: Received in formalin labeled "ADDITIONAL LYMPH NODE" is a 1.2 x 0.8 x 0.6 cm round, ovoid portion of tissue which is bisected to reveal a 0.7 cm tan-gray lymph node. The specimen is entirely submitted in cassette J.. Pathology Resident Pathology Resident Microscopic Description A-F: Performed. G: Sections show a moderately differentiated adenocarcinoma composed of highly irregular, tightly packed glandular structures with pleomorphic. nuclei involved by extensive areas of necrosis, desmoplastic reaction and chronic inflammation. The tumor is surrounded by adenomatous colonic mucosa with tubulovillous architecture. The tumor seems to invade the sigmoid colon wall and penetrates into the muscular bladder wall extending close to the bladder mucosal urothelium, but without directly involving it. The bladder mucosa shows extensive hemorrhagic cystitis with subepithelial hemorrhage and congestion and extensive inflammatory infiltrate and edema within the mucosal lamina propria. There is extensive acute serositis. involving the peritoneum with submesothelial polymorphonuclear cells. This acute inflammatory process involves the resection margins, as well. An area of intramural colonic abscess is identitied near the distal aspect underlying the tumor. H-J: Performed. This case was reviewed by the staff pathologist listed below.
+
+--- Page 8 ---
+Pathology Resident **Electronically Signed Out** Staff Pathologist 213
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diff --git a/output/text/217d10ca-f62b-4636-bf88-ca252a7cc1ca.txt b/output/text/217d10ca-f62b-4636-bf88-ca252a7cc1ca.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a458a53d87e04e18ff3d2c9e2e1d40d7cd399b60
--- /dev/null
+++ b/output/text/217d10ca-f62b-4636-bf88-ca252a7cc1ca.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Chisf of Pathology Phone Fax Specimen: Received: Status: Spec Type: SURGICAL P Subm Dr: OPERATION DATE: DOCTOR(S) : /cs-0-3 ISSEREOV Carcioma mnfiLtatng duct,Nos 85oo13 A. LT AXILLARY NODE DISSECTION Sit: breast, No3 C50.9 B. LT PARTIAL MASTECTOMY DESCREPTION PART A RECEIVED FRESH LABELED LEFT AXILLARY NODE DISSECTION, IS YELLOW-RED FATTY TISSUE MEASURING 15 X 12.5 X 4.0 CM. THIS IS EXAMINED FOR LYMPH NODES. THE NODAL TISSUE IS IDENTIFIED PRIMARILY AT ONE END OF THE SPECIMEN, NITH 75% CONSISTING OF BLAND YELLOW FATTY TISSUE.  MULTIPLE LYMPH NODES ARE IDENTIFIED AND GROSSLY POSITIVE. SECTIONS ARE SUBMITTED AS FOLLOWS: A1 THROUGH A8--ONE SECTION EACH OF GROSSLY POSITIVE LYMPH NODES WITH A RIBBON CLIP IDENTIFIED IN THE NODE CORRESPONDING TO A2. NOTE THAT MIRROR IMAGE RESEARCH BLOCKS ARE TAKEN ON EACH. A9 AND 10--ONE NODE EACH BISECTED, A11--TWO NODES EACH BISECTED, A12--TWO NODES, A13--ONE NODE BISECTED, A14--ONE NODE BISECTED, A15--ONE NODE BISECTED, A16 THROUGH A19--ONE GROSSLY FAT-REPLACED NODE TOTAL. PART B RECEIVED FRESH LABELED  LEFT PARTIAL MASTECTOMY LONG STITCH LATERAL SHORT STITCH SUPERIOR, IS AN OVOID PORTION OF YELLOW-PINK FATTY TISSUE MEASURING 11.5 X 7 X 4.7 CM IN GREATBST DIMENSIONS. THE SPECIMEN IS ORIENTED BY TWO SUTURES. A LARGK PALPABLE MASS IS PRESENT MEDIALLY.  SECTIONING REVEALS THIS PALPABLE MASS TO HAVE A FIRM PINK-TAN GRITTY CUT SURFACE MEASURING 4.0 X 2.8 X 3 CM IN GREATEST DIMENSIONS. THIS LESION EXTENDS TO THE INFERIOR MARGIN AND IS O.4 CM FROM THE MARGIN GROSSLY. IT IS 0.6 CM FROM THE DEEP MARGIN, 0.8 CM FROM THE SUPERFICIAL MARGIN AND GREATER THAN 1 CM FROM ALL OTHER MARGINS. SECTIONING THE LATERAL ASPECT OF THE SPECIMEN CONSISTS OF BLAND YELLOW FATTY TISSUE. SECTIONS ARE SUBMITTED AS FOLLOWS: B1--PERPENDICULAR MEDIAL MARGIN, B2--TUMOR (MIRROR IMAGE TO PROTOCOL), B3--LESION AND DEEP MARGIN, B4--LESION AND DEEP INFERIOR MARGIN CLOSEST TO TUMOR, B5--INFERIOR SUPERFICIAL MARGIN WITH LESION, B6--LESION AND SUPERFICIAL MARGIN (MIRROR IMAGE TO PROTOCOL), B7--SUPERFICIAL SUPERIOR MARGIN, B8--SUPERIOR DEEP MARGIN.  NOTE THAT B2 THROUGH B8 CONSTITUTE ONE FULL CROSS-SECTION OF THE LESION IN ITS GREATEST DIMENSION. B9--PERPENDICULAR LATERAL MARGIN, B1O--TISSUE FROM LATERAL ASPECT OF THE SPECIMEN, B11--TUMOR AND SUPERFICIAL MARGIN (MIRROR IMAGE TO PROTOCOL), B12--TUMOR (MIRROR IMAGE TO PROTOCOL).S UUID:B3D6A0F7-5E3C-4921-8399-6458E5222CC5 TCGA-A2-A0YG-01A-PR Redacted
+
+--- Page 2 ---
+Phone Fax Specimen: Received: Status: Spec Type: SURGICAL P Subm Dr: PATH PROCRDURESS PROCEDURES : 88307/2, A BLK/19, B BLK/12 FINAL DIAGNOSIS PART A LEFT AXILLA, LYMPH NODE DISSECTION: METASTATIC BREAST CARCINOMA IS IDENTIFIED IN 14 OF 18 NODES EXAMINED AND EXTRANODAL EXTENSION IS MULTIFOCALLY PRESENT. PART B LEFT BREAST, PARTIAL MASTECTOMY: 1.  POORLY DIFFERENTIATED _INTRADUCTAL AND INFILTRATING DUCT CARCINOMA, NUCLEAR GRADE III, HIGH MITOTIC INDEX AND TUBULE FORMATION 2, FOR A TOTAL NOTTINGHAM SCORE OF 8. DCIS OF THE SOLID TYPE COMPRISES APPROXIMATELY 5t OF THE TUMOR. 2. THE GROSS TUMOR HAS A MAXIMUM DIMENSION OF 4 CM. THE INVASIVE TUMOR IS IDENTIFIED 6 MM OR MORE FROM THE INKED MARGINS OF EXCISION. $. LYMPHOVASCULAR INVASION IS PRESENT. 5. BIOPSY CHANGESS ARE PRESENT. 1 signed (prelim.) (signature on file) I.D.
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diff --git a/output/text/217daeab-ff4e-411b-aa21-42f627e2bd88.txt b/output/text/217daeab-ff4e-411b-aa21-42f627e2bd88.txt
new file mode 100644
index 0000000000000000000000000000000000000000..74fee3440ec12fa824f812fc0997c52d893be4a9
--- /dev/null
+++ b/output/text/217daeab-ff4e-411b-aa21-42f627e2bd88.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:759F9B5B-2E5C-49E6-8E9B-32B265D1BE73 TCGA-5M-AATE-01A-PR Redacted Date: SPECIMEN: Ascending colon, cecum, terminal ileum, appendix PROCEDURE: Right hemicolectomy with terminal ileectomy MACROSCOPY - The specimen measures 22.5 cm in length and 5.5 to 7.5 cm in diameter. - The terminal ileum segment has a length of 4.5 cm and a diameter of 2.5 cm, with no identifiable macroscopic pathologic features. - The cecum contains a vegetative, infiltrative, well delimitated lesion, continuous to the lumen of the appendix and adjacent to the ileocecal valve, 5.5 cm away from the nearest surgical margin (ileal margin). - The lesion measures 6.5 cm and penetrates the full thickness of the bowel wall and the two proximal thirds of the appendix. - A number of lymph nodes were dissected from the pericolic fat; diameters ranging from O.3 to 1.1 cm. MICROSCOPIC EXAMINATION - Moderately differentiated tubular adenocarcinoma of the cecum, with extension to the appendix; - Microscopic tumor extension: tumor penetrates the full thickness of the cecum wall, extending. to the pericolic fat; - Perineural invasion: present; - Lymph-vascular invasion: present; - Moderate desmoplastic stromal reaction, with mild tumoral lymphocytic infiltrate.. - Surgical margins free of neoplastic involvement; - Number of lymph nodes examined: 15; IQD 6 3 - Number of lymph nodes involved: 0; - Stage: T3a pN0. dlncarsnomo> Ns3 814o/3 'seniCeruronos tibular 8x113 PATHOLOGISTS CICE foeendeney CsLew C 18 I eeum C18. 1O 5/21|14
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diff --git a/output/text/21911a45-3e28-4c0c-8680-9fbfcd525844.txt b/output/text/21911a45-3e28-4c0c-8680-9fbfcd525844.txt
new file mode 100644
index 0000000000000000000000000000000000000000..92810daa723197b3cfd9d678ac7f7a4ad3c924be
--- /dev/null
+++ b/output/text/21911a45-3e28-4c0c-8680-9fbfcd525844.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+CGA-A6-2684 SPECIMEN A. Apical node. B. Right hemicolectomy. CLINICAL NOTES PRE-op DIAGNosIs: Adenocarcinoma of cecum. GROSS DESCRIPTION A. Received fresh labeled "apical node" is an ovoid, 1.0 x 0.6 x 0.5 cm. soft tan pink tissue which is bisected and entirely submitted in one block. As-1. B. Received fresh labeled "right hemicolectomy" is a previously unopened 28 cm. segment of proximal right colon with attached 17 cm. of distal ileum surfaced by smooth to scabrous tan-pink serosa with a moderate amount of attached mesocolon and mesentery. An unremarkable 3.7 cm. appendix averaging 0.5 cm. in diameter is present. The proximal and distal margins measure 3.9 and 6.1 cm. in circumference respectively. On opening, there is a 5.3 x 2.0 cm. rubbery tan-pink-red lesion at the ileocecal valve.. A portion of the lesion and a portion of normal are submitted for tissue procurement as requested. On sectioning, the lesion has a maximal thickness of 1.3 cm., grossly extending into the muscularis to within 0.5 cm. of the closest ink-free radial serosal surface. The remaining ileal and colonic mucosa is unremarkable, glistening tan-pink with regular folds and the walls average 0.5 cm. in thickness. Multiple slightly rubbery pale tan tissues in keeping with lymph nodes measuring up to 1.0 cm. in greatest dimension are recovered from the attached mesocolon and mesentery. Representative sections are submitted in 12 blocks as labeled. Rs-12. BLOcK suMMARY: 1 - proximal and distal margins; 2, 3 - tumor full thickness to ink-free radial serosal surface; 4, 5 - tumor to.
+
+--- Page 2 ---
+GROSS DESCRIPTION adjacent mucosa; 6 - random ileal and colonic mucosa; 7 - appendix; 8-10 - eight whole lymph nodes per cassette; 11 - seven whole lymph nodes; bisected largest lymph node. MICROSCOPIC DESCRIPTION A. The apical lymph node demonstrates one lymph node with. no evidence of metastatic disease. B. The following template applies to the right. hemicolectomy: Histologic type: Adenocarcinoma. Histologic grade: Moderately differentiated.. Primary tumor (pT): 5.3 cm., extending into, but not through, the muscularis propria (pT2). Proximal margin: Negative. Distal margin: Negative. Circumferential (radial) margin: Negative.. Vascular invasion: Not identified. Regional lymph nodes (pN): No evidence of metastasis in thirty-two additional lymph nodes (pn0). Non-lymph node pericolonic tumor: Not identified. Distant metastasis (pM): Cannot be evaluated by this specimen. (pMX). Other findings: The appendix is unremarkable.. 3, 5 DIAGNOSIS A. Apical lymph node, resection: No evidence of metastasis in one lymph node (0/1). B. Right colon, hemicolectomy: DIAGNOSIS Adenocarcinoma, moderately differentiated, 5.3 cm., with. extension into, but not through, muscularis propria.. Surgical margins uninvolved. Thirty-two lymph nodes with no evidence of metastatic. disease (0/32). Appendix with no pathologic abnormality..
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diff --git a/output/text/21b00e0d-bf3d-40c3-9078-674acdf7ab98.txt b/output/text/21b00e0d-bf3d-40c3-9078-674acdf7ab98.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c22d18e4e4f2525848c22f568d60c6e5ddc8841e
--- /dev/null
+++ b/output/text/21b00e0d-bf3d-40c3-9078-674acdf7ab98.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:3C94BBAC-923E-43F0-B5DC-01207868AD05 TCGA-AN-A0XT-01A-PR Redacted TSS Patient ID Case #: JOB:. Sex: Female Ethnicity (Race): Cancer Sample Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma Date of Procurement: Anatomic Site: Breast Tumor location: Primarye Tissue Specification: Tumor Specimen Matrix: Tissue Specimen Format: OCT Container: block Type of Procurement: surgery Grade: 2. T Stage: 1c N Stage: 1a M Stage: 0 Treatment: none. Treatment Details: n/a Normal Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw Matrix: Blood Specimen Format: frozen Container: tubee Date of Procurement: 1cs-0-3 c50.9 Site: Breast, Nos h 10/21/1
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diff --git a/output/text/21b8d2f9-37f6-4191-9067-e1988dbe866e.txt b/output/text/21b8d2f9-37f6-4191-9067-e1988dbe866e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fd98f402d1f06e2f84a66dca1a1f1b8ea6000966
--- /dev/null
+++ b/output/text/21b8d2f9-37f6-4191-9067-e1988dbe866e.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SPECIMENS: A. LEFT COLON SPECIMEN(S): A. LEFT COLON GROSS DESCRIPTION: A. LEFT COLON Received fresh is an unoriented, closed segment of colon measuring 28 cm in length. The external. circumference is 8.2 cm. The serosa has numerous adhesions and a firm nodule measuring 11 x 8.5 x 6 cm. The serosa is inked black. The specimen is opened; there is an annular, indurated, ulcerated mass with serpentine borders measuring 10.7 x 8.5 x 6 cm. It is necrotic and extends through the muscular propria into the mesocolonic fat. It is located 8 and 10 cm from either surgical margin. 2.5 cm from the mass and 7.5 cm from the margin is a pedunculated polyp measuring 4.5 x 3.7 x 3 cm. It has. superficial a depth of invasion. Extending from the sessile polyp to the margin are numerous polyps ranging from 0.1 to 0.3 cm. Multiple lymph nodes are identified. A portion of the mass is submitted for tissue procurement. Representative sections are submitted as follows: A1-A2: margins A3-A5: mass including deep margin A6-A7: mesocolonic fat and mass A8: mass and possible diverticula A9-A10: mass in relationship to normal-appearing mucosa A11-A14: mass extending into the mesocolonic fat A15: polyps A16-A17: section of pedunculated polyp en bloc A18: pedunculated polyp and stalk A19: pedunculated polyp A20: normal-appearing mucosa A21-A24: proximal 6 lymph nodes each A25-A27: proximal 4 lymph nodes each A28: proximal 1 matted lymph node A30-A38: distal 6 possible lymph nodes each A39-A40: distal 2 bisected lymph nodes each DIAGNOSIS: A. LEFT COLON, RESECTION: -MODERATELY DIFFERENTIATED ADENOCARCINOMA OF COLON, INFILTRATING THROUGH MUSCULARIS PROPRIA INTO SUBSEROSA WITH PERINEURAL INVASION. - EXTENSIVE INTRAMURAL SUPPURATIVE NECROSIS -TUBULOVILLOUS ADENOMA WITH FOCAL HIGH GRADE DYSPLASIA -HYPERPLASTIC POLYPS(MULTIPLE) -MARGINS NEGATIVE -METASTATIC ADENOCARCINOMA IN ONE OF EIGHTY TWO LYMPH NODES (1/82) SEE SYNOPTIC REPORT SYNOPTIC REPORT - COLON & RECTUM Specimens Involved Specimens: A: LEFT COLON Specimen Type: Left hemicolectomy Tumor Site: Left (descending) colon Tumor Configuration: Exophytic (polypoid) Ulcerating Tumor size: 10.7cm Additional dimensions 8.5cm x 6cm WHO Classification Adenocarcinoma 8140/3 Histologic Grade: G2: Moderately differentiated. Extent of Invasion: Subserosa Margins: Margin(s) uninvolved by invasive carcinoma (Proximal, Distal, Radial) Distance of invasive carcinoma from closest margin: 0.1cm Venous/Lymphatic Invasion:. Absent Perineural Invasion: Present
+
+--- Page 2 ---
+Additional Pathologic Findings: Adenoma HYPERPLASTIC POLYPS Extent of Resection:  R0: Complete resection with grossly and microscopically negative margins Lymph Nodes: Positive 1 / 82 Extranodal extension: Absent Implants: Absent Pathological Staging (pTNM):  pT 3 N 1 M X CLINICAL HISTORY:  None given PRE-OPERATIVE DIAGNOSIS: Colon mass
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diff --git a/output/text/21bd208f-b1df-4ae8-bc96-4c1353683e82.txt b/output/text/21bd208f-b1df-4ae8-bc96-4c1353683e82.txt
new file mode 100644
index 0000000000000000000000000000000000000000..323d9177d23c0f7e80c83657e9a64a595d6ca9ca
--- /dev/null
+++ b/output/text/21bd208f-b1df-4ae8-bc96-4c1353683e82.txt
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+
+--- Page 1 ---
+Clinical Diagnosis & History: year old male with left renal mass. Specimens Submitted: 1: KIDNEY AND ADRENAL GLAND, LEFT, TOTAL NEPHRECTOMY, ADRENALECTOMY DIAGNOSIS: KIDNEY AND ADRENAL GLAND, LEFT, TOTAL NEPHRECTOMY, ADRENALECTOMY: Tumor Type: Renal cell carcinoma - Chromophobe type Tumor Size: Greatest diameter is 15.5 cm. Local Invasion (for renal cortical types): Not Identified Renal Vein Invasion:. Not identified Surgical Margins: Free of tumor  Non-Neoplastic Kidney: Unremarkable Adrenal Gland: Not involved Lymph Nodes: Free of tumor Number of nodes examined:5 Staging for renal cell carcinoma/oncocytoma: pT2 Tumor >7.0 cm in greatest dimension limited to the kidney 1 ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Page 1 of 2
+
+--- Page 2 ---
+Gross Description: 1) The specimen is received fresh for frozen, labeled "Left kidney, adrenal and hilar lymph nodes". It consists of a grossly recongnizable kidney whose appearance is markedly altered by a large mass localized to the lower pole. Attached to the upper pole of the kidney is a portion of fatty tissue investing a grossly recognizable adrenal gland. An attached segment of ureter is identified at the hilum. The overall measurements of the specimen are 22.0 x 14.0 x 8.5 cm. The specimen weighs altogether 905gm.  The specimen is bivalved to demonstrate a large corasely lobulated well-circumscribed and possibly encapsulated tumor with fleshy, homogenously pink-tan cut surface with multiple scattered small cystic areas. The tumor measures 15.5 x 13.0 x 8.5 cm. The tumor replaces the entire lower pole of the kidney.  It appears to be pushing on the renal sinus fat but does not seem to. invade it or extend into the collecting system. No macroscopic vascular invasion is noted. The tumor appears to grossly extend. into the perirenal fat but not through the gerota's fascia. The remainder of the kidney is grossly unremarkable. The adrenal gland is dissected off the kidney.  It measures 5.3 x 2.6 x 0.9 cm, weighs 7 gm and is grossly unremarkable both from outside and on the cross-section. The hilar fat is searched for lymph nodes. Several possible lymph nodes are dissected.  Samples of tumor and normal kidney tissue are submitted for. Gross photographs are taken. Representative sections are submitted for frozen section diagnosis and paraffin blocks. Summary of Sections: FSC - frozen section control M margin TC - tumor to capsule TK - tumor to kidney NLK - normal to kidney AD-adrenal PLN -- probable lymph nodes Summary of Sections: Part 1:  KIDNEY AND ADRENAL GLAND, LEFT, TOTAL NEPHRECTOMY, ADRENALECTOMY Block Sect. Site PCs 1 ad 1 1 fsc 1 1 m 3 1 nlk 1 2 pln 4 4 tc 6 5 tk 5 Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS:  RENAL CORTICAL TUMOR. FAVOR CHROMOPHOBE RENAL CELL CARCINOMA. PERMANENT DIAGNOSIS: SAME Page 2 of 2 END OF REPORT
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diff --git a/output/text/21f86843-b9e7-413e-a467-697113dfd86c.txt b/output/text/21f86843-b9e7-413e-a467-697113dfd86c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..326c5ba777c1ff511886e676a09367642caa0361
--- /dev/null
+++ b/output/text/21f86843-b9e7-413e-a467-697113dfd86c.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+SURGICAL PATHOLOGYREPORT ** ADDENDUM REPORT ADDENDUM REPORT: NUMBER TWO Right colon, partial cslectomy: Poorly diffrentiated adenocarcinoma, deficlent gene expression for MLH-1 and Pms-2; intact gene expression for M$h-2 and MSH-6 (immunoh'stochemistry). Ses comn ent.. COmmENT: The tunior is DNA mismatch repair deficient, and should also exhibit high frequency microsatelite instabrity. Most tumors with loss of MLH1 and PhS2 protein e:presslon have primary undertying defects in MLH1 expression, with co-existent loss of exoresslon of the binding partner protein PMS2. In most casts (about so%) MLH1 loss is caused by somatic hypermethylation of the promoter region of the MLH1 gene. This is a common mechanism invoived in the progression of serrated neoplasms of ths right colon. Some individuals with these tumors may have an inherited.  predisposition to the fomation of mutiple serrated neoplasms (hyperplastic/serated polyposis), although tha genetic basis of this syndrome is nknown. These individuals ar > at increased risk of metachronous cancers of tha right colon. About 10% of MLH1 deficient tumors are caused by inherited germmline defects In the MLH1 gene (Lynch syndrome; also know as heredtary non-. polyposis colorectal cancer or HNPcC). The posslbuity of an underlying PMS2 germine defect cannot be axcluded. The tumor doos not reveal a BRAF mutation (see below) which is often seen with somatlc or hypermethylation of the promoter region of the MLH1 gene. But to further clarify a block of tumor is submitted to the Mayo Clinic Laboratory for hypernethylation testing.. Family history evalu ation and additonal testing courd be heipful io detemining if MlH1 loss in the current tumor is caused by methylation or germline. mutation. Genetio counseling and testing should be considered if clinkally Indicated. DNA mismatch repsir deficient cancers are associated with Improved overal survival. Some studies also demonstrate resistance to 5-FU based Chemotherapy and sensitivity to irinotecan (CPT-11). ADDENDUM REPCRT: NUNBER ONE BRAF Mutation Ane lysis SPECIMEN SOURE: COLON PArAFFiN BLOCK NUmBER: iS11-22551, 6 BrAf Mutation Ar alysis: NOt Detecte. This result was revi swed and Interpreted by Based on sequencx: analysis, no mutations were detected in B-RAF exon 11, 12 and 15. Cancer-activating E RAF rrutations can be found in 14% of colorectal cancer, 2% of lung cancer, and 40% of thyroki cancer. Presence of BRAF mutation In colorectal cance: has beon reported to render the tumor resistant to anti-EGFR therapy. Documented BRAf polymorphism is usually not reported and is a neutal variant (no amino acid change). This assay may nol be abl to detect mutation if the tumor constitutes less than 15-20% of analyzed sample. However, we specificaly microdissect tumor and selectively analyze the tumor in the provided tissue. ...... The aRAF mutetion analysis from Qusst Diagnostics uses a DNA-based PCR-sequencing assay to detect somatic mutations on exon 11, 12, and 15 of BRAF, which cove: 102 out of 104 reported mutatfons (99.5% incidence). This test was deve oped and its performance characteristics Performance chare cteristiks refer to the analytical performance of the test. BRAF Mutation An ahsis SPECIMEN SOURCE: COLON PARAFFIN SLOCH NUMBER: Wstm
+
+--- Page 2 ---
+BRAF Mutaton^AnaJysis: TNP TNP-TEST REQUEST CANCELLED - NO CHARGE. NORMAL TISSUEI BLOCK FOR NSI Cancer-activating BRAF mutations can bo found in 14% of colorectal cancer, 2% of lung cancer, and 40% of thyrod cancer. Presence of BRAF mutstion in colorectal cancsr has been reported to render the tumor reslstant to anti-EGFR therapy. Documented BRA = potymorphism is usualy not reported and is a neutra! variant (no amino acid change). This assay may nt be ab!e to detect mutation if the tumor constitutes less than 15-20% of analyzed sample. However, we specifically microdissect tumor and selectively annlyze the tumor in the provided tissue. The BRAF mutatic n analysis from Quest Diagnosdcs uses a DNA-based PCR-sequencing assay to detect somatic mutations on exon 11, 12, and 15 of BRAF, which cover 102 out of 104 reported mutations (99.6% incidence). This test was deve loped and its performance characteristics have beon deternined by Performance chanderistics refer to tha analytica! periormance of the test. Test performed at DIAGNOSIS: Right colon, partia! colectomy: Tumor <haracteristics: 1. Histologkc type: Adonocarcinoma. 2. Histologic grade: Poriy differentiated. 3 Tumor site: Ce xum. 4. Tumor size: 12.3 x 5.0 x 1.5 cm. 5. Tumor subtype: Mucinous tumor componant present.. 6. Tumor extensio n: Tunor invades through muscularis propria into adjacent fat to involved inked surface. 7. Margins: Proxin ial margin (smal bowel) - negative; dstal margin - negative; circumferential - (radial) margin - positive (tumor extends to inked Sunface). B. Lymphovascular invasion: Present. Lymph Hode Status:. 1. Nine of sixteen ymph nodes demonstrating metastatic, poorly differentiated carcinoma (9/16). 2. Largest replace  lymph node measures up to 1.4 cm.. Other: 1. pTNM stage: p'T4a, pN2b. CONMENTS: Multiple sections oi the very large tumor reveals a poorly differentiated adenocarcinoma, composed predominantly of solid nests of cexs having a moderete amount tf cytoplasm and large vesicular nuclel with prominent nucleol. Some rudimentsry gland formation is evident. Eisewhere, there Is a signet ring appeare nce to the ces and also takes of mucin can be identified. The tunor invades transmuraly Into the adjacent fat and focally to the inked surface of the fat (cresuned radial margin). Extensive angiolymphatic invasion is seen within the tunor. Multiple (ymph nodes are involved by metastatic carcinoma (see abxive). Due to the poorly d fferentiated appearance of the neopiasm, a serios of Immunoperoxidase stains are performed. The tumor shows moderate to focally strong immunoreactivity for CK7. A stain for CK20 is negative. The CDX imanunostain reveals some focal Immunoreactivity within tummor cell nuclei. Stains for CK5-S, synaptophysin, PSA, chromogranin and TTF-1 are negative. A stain for calretinin is negative also (no nuclear reactivity). This pattem of immunostalning is sonewhat unusual for a colorectal priknary, since most show CK20 mmuncreactivity and are negative for Ck7. Howover, the focal CDX2 positivity is supportive cf a colorectal primary. In addition, the poony differentiated appearance of neoplasm and the right sided location suggests a possible MS! (micrsatelite instability) high type of lesion. MSI high carcinomas often do show a reverse staining pattern for CK7 and CK20 Immunohistochemi :al stains for mismatch repalr enzymes (evaluation for HNPCC) and/or MSt PCR testing wi! be performed on the tumor and reported as an addendum.d The groin lesion .. . was revlewed as Is a squamous cell carclnoma of the skin..
+
+--- Page 3 ---
+CLINICAL HISTOItY: Preoperative Dlagr osis: Colon carcinoma. Postoperative Disg nosis: Symptoms/Radiologic Findings: SPECIMENS: Right colon. GrOss DEscrIp TiOn: The specimen is re ceived in a singke formatin filled container labeled with the patient's name I and consists of a right nemicolectomy. specimen comprist d of terminal ileum (11.5 cm in length x 1.8 cm in diamster), cecum/right colon (21.0 cm in kength and ranging from 4.0 up to 7.0 cm in dlameter), and v ermiform appendix (4.3 cm in length and ranging from 0.5 to 0.7 cm in diameter). The specimen is received stapled dlosed at both ends. The serosa i tan-pink and glstening with adherent yelow-tan mesocolonk fat and a portion of omentum. The cecal pouch is remarkable for a 12.8 x 5.0 x 1.5 cr. crcumferential fungating mass that approaches to within 11.0 cm of the ilial margin and 15.5 cm of the colon!c margin. On section,  this mass extend's nrough the muscularis and approaches to within 0.1 cm of the inked deep margin. The remainder of the mucosa is pink-tan and glistening with the jormal folds. No additional lesions are identified. Sections through the appendix reveai a 0.3 cn outpouching at the distal tip. The Iumen is pinpoint w ith no perforations or fecaliths.. Sections through tte ementum reveal a yellow-tan fiorofatty cut surface. No tumor is Identified. Within the mesocolonlc fat are multiple firm fatly possible lymph nodes ranglug from 0.5 un in a 3 am in greatest dimension. Many are involved by gray-white tumor. Representative sections are submitted in cassettes 1 througlt 19 labeled designated as follows: 1) colonlc margin, en face; 2) ileal margin, en face; 3- 6) mass to Inked deep margin; 7) mass to nomal; 8) vermiform appendix; 9 and 10) five whole possble lymph nodes in each cassette: 1i) four whole possible lymph nodes: 12) two whole poss Ible bisected lymph nodes (one Inked); 13 - 15) one whole possible bisected lymph node in each cassette: 16 - 19) one who!e possible quadrisec ed lymph node..  yedc w, green, and blue cassette are submitted for ge.  Additional represer tative sections are submkied as labeled: 20-23 mass to uninvolved mucosa. The blocks are labeled
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diff --git a/output/text/2205eb6d-137d-4dcd-8486-4ce996bac67d.txt b/output/text/2205eb6d-137d-4dcd-8486-4ce996bac67d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4d8c63904b6dad082155c6df839e511e462f5884
--- /dev/null
+++ b/output/text/2205eb6d-137d-4dcd-8486-4ce996bac67d.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis: Resected colon with a broad, ulcerated, moderately differentiated adenocarcinoma of. colorectal type, with infiltration of the pericolic adipose tissue, lymphangiosis carcinomatosa with tumor and seven local lymph node metastases. Tumor-free colon resection margins. Tumor-free mesenteric resection margin. The remaining mucous membrane of the colon displaying a circumscribed, ulcerous defect with remains of a tubular adenoma with moderate epithelial dysplasia, as well as a further small tubular. adenoma, likewise with moderate dysplasia (synonymously: mild intraepithelial neoplasia). Stage of tumor: pT3, pN2 (7/28), MX; G2, L1, V0, local R0
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diff --git a/output/text/220667b7-e6fa-4f50-aec1-8f93535f3115.txt b/output/text/220667b7-e6fa-4f50-aec1-8f93535f3115.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9438edf7877a1c4a29960eb0fbdb77d9e6f1d638
--- /dev/null
+++ b/output/text/220667b7-e6fa-4f50-aec1-8f93535f3115.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:84E6A935-1A49-4BC1-9669-3DEA161CF6FC Reda ed Name: Path No.: Mrn: Date Obtained:. D.O.B. (Age Date Received: Sex: F Physician: Location: SURGICAL PATHOLOGY **See Addendum/Procedure** ICDO SPECIMEN: 'arcintnis,ursiltstiy clce A:Lymph node, right axilla sentinel node, biopsy. B:Breast, right, lumpectomy 850015 Nos C:Lymph nodes, right axilla, dissection DIAGNOSIS(ES): C s0.4 A. Lymph node, right axilla sentinel node, biopsy: euadrost - Carcinoma in 1 sentinel node following carcinoma of right breast. As Os/i1/14 B. Breast, right, Iumpectomy:. - Carcinoma, invasive ductal type, moderately-differentiated, with focal mlcropapillary features, Nottingham's score 5 (2+2+1).. - Carcinoma, intraductal, comedo type with microcaicifications. - Lobular neoplasla, focal, classical type.. - Fibrocystic disease, proliferative, with apocrine metaplasia, sclerosing adenosis and microcalcifications. - Cicatricial fibrosis and organizing granulation tissue with fat necrosis, consistent with previous biopsy site. - Fibroadenoma, microscopic.. C. Lymph nodes, right axilla, dissection:. - No evidence of carcinoma in 14 lymph nodes. Date Dictated: CLinICAL INFORmATION: Breast cancer. GROSS DESCRIPTION: The specimen is received in three parts.. Part A is received fresh from the operating room for frozen section diagnosis in a container labeled with the patient's name and "R sentinel lymph node". It consists of one firm tan to red lymph node measuring 2.0 x 1.8 x 1.0 cm. The specimen is serially sectioned. Submitted in toto in three cassettes labeled AFS, A1 and A2. AFS = frozen section, A1 - A2 = remaining tissue. Part B is received unfixed in a container labeled with the patient's name and "R breast lumpectomy". It consists of a piece of yellow-white fibrofatty tissue measuring 10.5 x 9.0 x 6.0 cm. An ellipse of skin is not present. An X-ray is received. A localization needle is not noted. A short suture is noted indicating the superior margin and a row of long sutures are noted indicating the lateral margin. A mass is palpated in the center. The superficial surface is inked yellow Page i of 3
+
+--- Page 2 ---
+and the deep surface is inked black. The specimen is serially sectioned. On cut section, the mass is tan, firm, poorly. .circumscribed and measures 3.2 x 3.0 x 3.0 cm. The mass comes to 0.3 cm of the superficial, 0.5 cm of the deep and 2.5 cm of the lateral margins. The tissue is composed of 60% fat and 40% intermixed firm tan-white parenchyma. Representative sections are submitted in 29 cassettes labeled B1 - B29. Legend: B1 = mass and closest deep surface, B2 = mass and closest superficial surface(B1 and B2 = full thickness of mass),. B3 - 88 = mass with adjacent deep margin B9 - B17 - superficial margin over mass. 818 - B19 = mass B20 - B21 = superior B22 - B23 = deep margin in lateral part(ciosest to mass) B24 - B25 = lateral B26 - B27 = inferior B28 - B29 = rnedial. Part C is received unfixed in a container labeled with the patient's name and "R axillary lymph node dissection". It consists of two pieces of yellow-red fatty tissue measuring 4.0 x 2.7 x 1.0 cm and 10.0 x 7.0 x 1.0 cm. A suture is noted attached to one end of the larger piece of fatty tissue. Fourteen lymph moves measuring from 0.6 x 0.5 x 0.5 crn to 3.5 x 1.5 x 1.0 cm are identified. The lymph nodes are submitted in toto 10 cassettes labeled C1 - C10.. Legend: C1 = five intact nodes, C2 - C5 = one bisected node in each cassettes, C6 = one intact node, C7 - C8 = one large quadrisected node, C9 - C10 = nodes closest to suture(larger node is bisected).. INTRAOPERATIVE CONSULTATION: AFS: Metastatic carcinoma in lymph node. Performed by: Resident: Interpreted by:  Attending: MICROSCOPIC DESCRIPTION: I. TYPE OF SPECIMEN: Right breast, excisional biopsy/lumpectomy Right axillary node dissection II. LOCATION OF THE TUMOR: Upper outer quadrant III. TYPE OF NEOPLASM: Carcinoma,invasive - ductal type NO$ with micropapillary features. Histological Grading: Moderately differentiated (Nuclear grade 2 and Tubular & Glandular differentiation grade 2). Ductal carcinoma in situ, nuclear grade 3, multifocal 10%. Intraductal comedo subtype Necrosis is present within the intraductal subtype  Lobular neoplasia, type A (monomorphic), Focal in 2 of 29 slides  Iv. GROSS/MICRO FINAL INVASIVE TUMOR SIZE INTERPRETATION: 3.2 x 3.0 x 3.0 cm. V. BORDERS OF INVASIVE NEOPLASM: II-defined VI. VASCULAR SPACE INVASION: Present in lymphatics VII. CALCIFICATION: Present in both malignant and benign areas. Vil. NIPPLE: N/A IX. SKIN: N/A Page 2 of 3
+
+--- Page 3 ---
+X. ADJACENT BREAST TISSUE: Fibroadenoma (size 0.2 cm.) Cystic disease, proliferative XI. SURGiCAL MARGiN: No carcinoma is identified on surgical margins Tumor distance from closest deep (slide "B1") margin: 0.6 cm XII. AXILLARY LYMPH NODES: TOTAL: 15 HIGH POINT: 2 SENTINEL NODE: 1 XIII. POSITIVE LYMPH NODES: TotAL: 1 HIGH POINT: 0 SENTINEL NODE: 1 DEGREE OF iNVOLVEMENT: Extensive replacement EXTRANODAL EXTENSION: Present XIV. PECTORAL MUSCLE: No pectoral muscle identified This report has been reviewed electronically and signed on by Interpreted by: Attending: The diagnosis was rendered by the attending pathotogist. Addendum Date Ordered:s Status: Signed Out ADDENDUM Slides were reviewed by The diagnosis rendered is in agreement with the original diagnosis. This procedure/addenda has been electronically reviewed and signed on by Interpreted by:. Attending: Note: Immunochemistry testing performad at was developed and its performance characteristics determined by the Thase tosts were Interpreted in conjunction with external positive and internal negative controls, unless otherwise noted. it has not boen cleared or spproved by the U$ FDA. This test is used for clinical purposes only. It shouid not be regarded as investgatlonal or for research.
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diff --git a/output/text/222b0546-f84f-4839-a87c-458ba85c4fac.txt b/output/text/222b0546-f84f-4839-a87c-458ba85c4fac.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6336a47699ec324b40f834a1b74cd2bf6ac108f5
--- /dev/null
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+
+--- Page 1 ---
+Path (First Tumor) Tumor Site: Sigmoid Distal Date of Cancer Sample Procurement: .- Histology: Adenocarcinoma Description of other histology: Grade: Moderately Differentiated 3 C Yes Mucinous: 6 No r Yes r Unknown (Focal)  Yes Signet Ring Feature: 6 No C. Yes r Unknown (Focal) Histologic Heterogeneity: 6 No r Yes C Unknown Host Response: None Crohn's like reaction 6 None  Yes C Unknown Plasma cell rich stroma r No ( Yes C Unknown r Expansile Growth Pattern:  Expansile r Invasive C Unknown and Invasive Inflammatory Bowel Disease 6 No  Yes C Unknown Angiolymphatic invasion: 6 No ( Yes C Unknown Mutator Phenotype: 6 No ( Yes r Unknown Number of Slides 1 C Yes Garland Necrosis present: C No  Yes r Unknown (Focal) TIL Cells / HPF To Pathologist Comment: 1co-0-3 Adenocascinoma N0s 8140/3 C18.7 M 5/3/n UUID:6BA78869-CE10-4755-82A8-9096731A069C TCGA-DM-A28E-01A-PR Redacted ous Primen scirclt DISQUAIIED
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diff --git a/output/text/22489f23-84c2-4f40-9562-7678b66d09aa.txt b/output/text/22489f23-84c2-4f40-9562-7678b66d09aa.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5627d10db878403e7ab68874997a77aa4ae27445
--- /dev/null
+++ b/output/text/22489f23-84c2-4f40-9562-7678b66d09aa.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:AD07F611-0EEA-4890-A02C-6DA3F5F57C45 edacted Final Diagnosis 4/=s Breast, left, total mastectomy: Infiltrating ductal carcinoma, Nottingham grade II (of Ill), (tubules 2/3, nuclei 2/3, mitoses 3/3; Nottingham score 7/9], forming a 4.2 x 4.0 x 3.0"cm mass located in the upper outer quadrant of the breast [AJCC pT2]. Focal ductal carcinoma in situ, intermediate nuclear grade, comprising approximately 5% of tumor volume. The non-neoplastic breast parenchyma shows nonproliferative fibrocystic changes. Biopsy site changes present. The tumor does not involve the nipple, overlying skin, or underlying chest wall. All surgical resection margins, including deep margin, are negative for tumor (minimum. tumor free margin, 1.5 cm, anterior margin). Lymph nodes, left axillary sentinel, excision: Multiple (8) left axillary sentinel lymph nodes are negative for tumor (AJCCpN0(i- )(sn)). Blue dye was identified in lymph node Nos. 2A, 2B, and 2C. No blue dye was identified in lymph node Nos. 1, 3, 4, 5, and 6. Immunohistochemical cytokeratin stain was performed on the paraffin embedded sentinel lymph node tissue and confirms the H&E impression. Estrogen and progesterone receptor analysis and HER2/neu have been ordered on paraffin embedded tissues.. 1cs-0-3 carcioma, mfAtratn9 ouct,nos 850o/3 Sihe : breust, Nos C5o.9 4/25/11
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diff --git a/output/text/224bed6b-af39-41a9-aa37-72078edebe6d.txt b/output/text/224bed6b-af39-41a9-aa37-72078edebe6d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9088ec9caba3cc9574caa44139fd27fee419ea2c
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+1c0.0-3 Carunomn,nifjilmating duct and lobulev 8522|3 128/10 lu TSS: SPECIMENS: CQeF Sit: brsst,nos 050.9 A. WLE LEFT BREAST NEEDLE LOCALIZATION B. SENTINEL NODE #1 LEFT AXILLAS C. MEDIAL MARGIN LEFT BREAST UUID:DD9FDF38-29CA-4D11-8615-E2EEB5D601D1 TCGA-E2-A15G-01A-PR Redacted SPECIMEN(S): A. WLE LEFT BREAST NEEDLE LOCALIZATION B. SENTINEL NODE #1 LEFT AXILLA C. MEDIAL MARGIN LEFT BREAST INTRAOPERATIVE CONSULTATION DIAGNOSIS: Part A, Left breast, wide local excision, gross examination: Tumor (at least 3 cm in size) seen at inked green medial margin TPB, Sentinel lymph node #1, left axilla: Negative for tumor cells Diagnoses called at '. by Dr GROSS DESCRIPTION: A. WLE LEFT BREAST NEEDLE LOCALIZATION Received fresh labeled with the patient's identification and designated "wide local excision left breast needle localization" is an oriented, previously inked, 63-g. 8 x 5.5 x 3.7 cm needle iocalized iumpectomy specimen accompanied by two radiographs. The single suture designates anterior, double-lateral. Ink code: Anterior-yellow, posterior-black, medial- green, iateral-red, superior-blue, inferior-orange. The specimen is serially sectioned from medial to lateral into 7 slices revealing firm tan mass (clip in slice 3). 3.5 x 2 x 1.5 cm, located at the medial margin. A second ill-defined hemorrhagic  firm area, 1 x 0.9 x 0.6 cm, is identified in slice 6, approximately 1 cm from the mass, and approaches the nearest anterior margin at distance of 0.6-cm. A portion of the specimen is submitted for tissue procurement. The specimen is representatively submitted: A1-A4: Perpendicular sections medial margin, entirely submitted A5-A8: Slice 2, entirely submitted, A5-A6 demonstrate mass A9-A12: Slice 3, entirely submitted, A10 demonstrates clip A13: Slice 4, posterior/superior A14: Slice 4, superior/anterior A15: Slice 4, posterior/inferior A16: Slice 5, posterior/superior A17-A18: Slice 6, hemorrhagic firm area submitted entirely A19-A20: Representative perpendicular sections, lateral margin B. SENTINEL NODE #1 LEFT AXILLA  Received fresh labeled with the patient's identification and designated "sentinel lymph node number one left axilla" is a tan Jymph node measuring 3 x 1.5 x 1 cm. Touch preparations are performed. The entire specimen is submitted, B1-B2. C. MEDIAL MARGIN LEFT BREAST Received in formalin labeled with the patient's identification and designated *medial margin left breast" is an oriented (suture at final margin). 6g, 5.5 x 2.5 x 1 cm fragment of fibroadipose tissue. The finai margin inked black. The specimen is sectioned and submitted entirely, C1-C5. DIAGNOSIS: A. BREAST, LEFT, WIDE LOCAL EXCISION: - INVASIVE MIXED (DUCTAL/LOBULAR) CARCINOMA, SBR GRADE II, MEASURING3.5CM. -FOCAL DUCTAL CARCINOMA-IN-SITU, NUCLEAR GRADE 2/3, SOLID AND  CRIBRIFORM TYPE WITH MICROCALCIFICATIONS. - FIBROADENOMA / FIBROCYSTIC CHANGES. - PREVIOUS BIOPSY SITE CHANGES. (SEE SYNOPTIC REPORT) B. LYMPH NODE, SENTINEL #1, LEFT AXILLA, EXCISION: - ONE REACTIVE LYMPH NODE. - NO METASTATIC CARCINOMA IS SEEN (0/1). C. BREAST, LEFT, MEDIAL MARGIN, EXCISION: - BREAST TISSUE WITH FIBROCYSTIC CHANGESE - NO MALIGNANCY IS SEEN. SYNOPTIC REPORT - BREAST Specimens Involved Specimens: A: WLE LEFT BREAST NEEDLE LOCALIZATION B: SENTINEL NODE #1 LEFT AXILLAE C: MEDIAL MARGIN LEFT BREAST
+
+--- Page 2 ---
+Specimen Type: Excision Needle Localization: Yes - For mass Laterality: Left Invasive Furmor:  Present Multifocality: No WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 ( Mixed type garcinoma Tumor size: 3.5cm Additional dimensions: 2cm x 1.5cm Tumor Site: Upper outer quadrant Margins: Negative Tubular Score: 3 Nuclear Grade: 2 Mitotic Score: 1 Modified Scarff Bloom Richardson Grade: 2 Necrosis: Absent Vascular/Lymphatic Invasion: None identified Lobular neoplasia:  None Lymph nodes: Sentinel lymph node only Lymph node status: Negative 0/1 Micrometastases: No DCIS present  Margins uninvolved by DCIS DCIS Quantity: Estimate 2% DCIS Type: Solid Cribriform DCIS Location: Associated with invasive tumor. Nuclear grade: Intermediate Necrosis: Absent Location of CA++: DCIS Stroma ER/PR/HER2 Results ER: Positive PR: Positive HER2: Negative by IHC Performed on Case:outside slides (our consultation report) Pathological staging (pTN): pT 2 N O CLINICAL HISTORY: Invasive carcinoma, UOQ left breast, with enhancement patient for intraductal extension going anteriorly PRE-OPERATIVE DIAGNOSIS: Invasive carcinoma ADDENDUM: ONCOTYPE DX BREAST CANCER ASSAY RESULTS: Recurrence Score: 4 CLINICAL EXPERIENCE: Patients with a recurrence score of: 4 in the clinical validation study had an average rate of Distant Recurrence at 10 years of 5% ER Score: 11.5Positive PR Score: 9.9 Positive Her2 Score: 8.8 Negative Interpretation: Negative <6.5 Positive >= 6.5 PRNegative <5.5 Positive >= 5.5 Her2 Negative <10.7 Positive >=11.5 Equivocal = 10.7 - 11.4 See separate  report for further information. Test performed at: Gross Dictation: Microscopic/Diagnostic Dictation: Fauuiuyist,
+
+--- Page 3 ---
+Final Review: Pathologist, Final Review: Pathologist, Final: Pathologist, Addendum: Patholugist, Addendum Final: Pathologist. NISQUALIFE
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diff --git a/output/text/22923d7f-1e87-434e-8dd6-5aa27664bedd.txt b/output/text/22923d7f-1e87-434e-8dd6-5aa27664bedd.txt
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index 0000000000000000000000000000000000000000..0dc0aa48c510ca43108fb052725b55771f01b19d
--- /dev/null
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+
+--- Page 1 ---
+PECIMEN Right colectomy CLINICAL NOTES PRE-OP DIAGNosIS: Cecal cancer. GROSS DESCRIPTION Received fresh, for tissue procurement labeled "right colectomy" is a previously unopened, 13 cm. segment of proximal right colon with attached 10.5 cm. of distal ileum surfaced by smooth to scabrous serosa with a moderate amount of mesocolon and mesentery with multiple large palpable aberrant nodes. A 7.8 cm. appendix averaging 0.7 cm. in diameter is present. The proximal and distal margins measure 4.2 and 8.5 cm. in circumference respectively. On opening, there is a poorly defined, 9.0 x 5.5 cm. rubbery to friable tan white-pink tumor mass occupying the cecal pouch and extending up to the ileocecal valve. On sectioning, the tumor has a maximal thickness of 2.0 cm., grossly extending into the muscularis to within 0.3 cm. of the inked free radial serosal surface (see blocks 2 and 3). The ileal and remaining colonic mucosa is unremarkable glistening tan pink with regular folds and the walls average 0.5 cm. in thickness. Multiple soft to rubbery tan white to pink gold tissues in keeping with lymph nodes measuring up to 4.8 cm. in greatest dimension are recovered from the attached mesocolon and mesentery. The largest node appear grossly positive. Representative sections are submitted in 16 blocks as labeled. RS16. BLOcK suMMARy: 1 - Proximal and distal margins; 2 and 3 - tumor full thickness to inked free radial serosal surface; 4 and 5 - tumor full thickness within cecal pouch (point of continuity inked red); 6 - tumor to normal; 7 - Icv; 8 - random colon; 9 - appendix; 10-12 six whole lymph nodes per cassette; 13 and 14 - two grossly positive lymph nodes represented per cassette; 15 and 16 - one grossly.
+
+--- Page 2 ---
+GROSS DESCRIPTION positive lymph node represented per cassette.. MICROSCOPIC DESCRIPTION Histologic type: Invasive adenocarcinoma not otherwise specified. Histologic grade: Poorly differentiated with grade 3 nuclei Primary tumor (pT): Tumor invades through the muscularis propria. into the pericolonic fat (pT3) Proximal margin: Negative for tumor Distal margin:  Negative for tumor Circumferential (radial) margin: Negative for tumor Distance of tumor from closest margin: 10 cm. from ileal margin (proximal) Vascular invasion: Prominent lymphatic space invasion is noted (slide 5) Regional lymph nodes (pN): Prominent lymph node metastasis is documented with metastatic tumor in 11 of 23 lymph nodes (pN2b).. Non-lymph node pericolonic tumor: Present with extension of tumor. beyond lymph node capsules. Distant metastasis (pM): Cannot evaluate (pMx) Other findings: An adenomatous polyp is identified adjacent to the tumor.  The appendix is histologically unremarkable and the background sections of colon are histologically unremarkable. 5, 3260F DIAGNOSIS A. Colon, right ileal colectomy: Invasive poorly differentiated adenocarcinoma, tumor invades. through muscularis propria into pericolonic fat (pT3). Margins are negative for tumor. Lymphatic space invasion present. Metastatic adenocarcinoma present in 11 of 23 lymph nodes.. (pN2b) Extranodal tumor present. End Of Report
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diff --git a/output/text/22d86f32-1470-4bc4-a71f-37bd5533d7e2.txt b/output/text/22d86f32-1470-4bc4-a71f-37bd5533d7e2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6777483394875053d3f5b12b6b4b885fb63a55a6
--- /dev/null
+++ b/output/text/22d86f32-1470-4bc4-a71f-37bd5533d7e2.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+IcD-0=3 8ite: breaot Nos c509 'fS/s Hosfu h Surg Path CLINICAL HISTORY: Right breast FNA negative. 2 x 1.5 cm tumor. Oriented by Dr. grossly. GROSS EXAMINATION: A. *Right breast biopsy", in formalin. The specimen consists of a 6.0 x 3.8 x 2.8 cm sample of firm, yellow-white, fibroadipose tissue that is received previously incised. The specimen was oriented grossly by Dr. , and the lateral operative margin inked in blue, medial operative margin inked in black, and the anterior operative margin inked in red. The specimen is sectioned superiorly to inferiorly revealing a firm, white scuirrious uniform lesion with irregular borders extending up to 2 cm in greatest dimension. The lesion abuts the medial and inferior operative margins. The specimen is submitted in toto in Blocks Al-Al3 from inferior to superior and anterior to posterior. Also received is a sample of firm, yellow-white fibroadipose tissue measuring 4.3 x 4.0 x 1.3 cm in size. The sample is oriented by Dr. and the new. surgical margin is inked in blue and the old surgical margin is inked in black. The new surgical margin represents the true margins. Serial sectioning reveals a firm, white, infiltrative lesion extending through much of the specimen and abutting the blue inked surgical margin. Submitted in toto in Blocks Al4-A20. Samples of the lesion were obtained for Er/pr studies.. FOrM Dr. DIAGNOSIS: A. "RIGHT BREAST BIOPSY" (EXCISIONAL BIOPSY): per tss patn userepancy INFILTRATING CARCINOMA PRESENT, HISTOLOGIC TYPE, DUCTAL. Fom, TCGAtumor is cribriFyrm N.S.A.B.P. HISTOLOGIC GRADE, 2 OF 3. N.S.A.B.P. NUCLEAR GRADE, 2 OF 3. UUID: 84A8BA4A-35F0-46C4-BDB0-64C033AFD1A8 GROSS TUMOR SIZE, 2 CM. TCGA-B6-A0X0-01A-PR Redacted SIZE OF INVASIVE COMPONENT, 2 CM. DUCTAL IN-SITU CARCINOMA, EXTENSIVE. MULTIFOCAL TUMOR, NO. TYPE OF IN SITU CARCINOMA, NON-COMEDO SUBTYPES. SIZE OF IN SITU CARCINOMA, 2 CM. STATUS OF NON-NEOPLASTIC BREAST TISSUE, APOCRINE METAPLASIA AND DUCTS ECTASIA. LYMPHATIC/VASCULAR INVASION, NOT PRESENT. SURGICAL MARGIN STATUS, NEGATIVE. MICROCALCIFICATIONS NOT PRESENT. ESTROGEN/PROGESTERONE AND CELL CYCLE ANALYSIS PENDING, YES. METHODOLOGY, FRESH TISSUE. SEE NOTE. RESULTS WILL BE ISSUED IN AN ADDENDUM. NOre: The original biopsy specimen shows carcinoma in situ to both lateral and medial margins. The reexcision specimen shows operative margins to be free of malignancy. This specimen shows a single small. focus of residual invasive carcinoma, infiltrating ductal type, N.s.A.B.p. histologic grade 2, nuclear grade 2, and residual intraductal carcinoma of non-comedo type. Breast tissue away from the carcinoma in this specimen shows blunt duct adenosis and a small radial scar. 1 of 2
+
+--- Page 2 ---
+Verified by:. Pager# Date Signed: ADDENDUM 1: Tissue was sent to the for assay of the Estrogen and Progesterone receptors. an estimated fmol valve of 166. The Progesterone receptor was judged as positive with an estimated fmol valve of 1l. Please report to more complete details. : for Verified by:. Pager Date Signed:. 2 of 2
+
+--- Page 3 ---
+TCGA Pathologic Diagnosis Discrepancy Form V4.00 Instructions: The TcGA Pathologic Diagnosis Discrepancy Form should be completed when the pathologic diagnosis : documented on the initial pathology report for a case submitted for TcGA is inconsistent with the diagnosis provided on the Case Quality Control Form completed for the submitted case.. Tissue Source Site (Tss): .-.. TSS Identifiet. .  TSS Unique Patlent Identifier: Completed By (interviewer Name on Completed Date: Diagnosis Information.. Data Element Entry Alternatives Working Instructions Provide the diagnosis/ histologic subtype(s) documented on Pathologic Diagnosis the initial pathology report for thls case.lf the histology for  Provided on Initial Pathology Report Qresert, DuctoI Histologic features of Cibriform Provide the histologic features selected on the TCGA Case Quality Control Form completed for this case.. the sample provided for TCGA, as reflected on the CQCF. Discrepancy between Pathology Report and Case Quality Control Form Provide the reason for Provide a reason describing why the diagnosis on the inltial the discrepancy S0mple Subm#ed pathology report for this case isnot consistent with the between the pathology djagnosis selected on the TCGA Case Quality Control Form. report and the TCGA reviewed smd Case Quality Control Form. Oqreed tnat itis Cribri Form.  Name of Tss Reviewing Provide the name of the pathologist who reviewed this case. Pathologist or. forTCGA. Biorepository Director I acknowledge that the above information provided by my institution is true and correct and has been quallty controlled. TSS Reviewing Pathologist or Biorepository Director Date I acknowledgs that the above Information provided by my instituton is true and correct and has been quality controlled. The Attending Pathotogist or the uxartment Chairman has been Informed or is aware of the above discrepancy in dlagnoses. Principal Investigator Signature Date
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diff --git a/output/text/22db35bf-aae0-4903-9e8c-c4b765eaf786.txt b/output/text/22db35bf-aae0-4903-9e8c-c4b765eaf786.txt
new file mode 100644
index 0000000000000000000000000000000000000000..25e9184ad1f41946dce5f06f6dba29d291cfd906
--- /dev/null
+++ b/output/text/22db35bf-aae0-4903-9e8c-c4b765eaf786.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SPECIMEN SUBMITTED: Right Kidney Procedure dateTissue received Report Date Diagnosed by Kidney, right. radical nephrectomy: -Renal cell carcinoma, chromophobe type, see synoptic report. -Unremarkable adrenal gland Kidney: Nephrectomy, partial or radical Synopsis. MACROSCOPIC Specimen Type: Right radical nephrectomy.. Focality:Unifocal. Tumor Size Greatest dimension:7.2 cm.. Macroscopic extent of tumor: Tumor limited to kidney MICROSCOPIC Histologic Type: Chromophobe renal cell carcinomae Histologic Grade: G4: Nuclei bizarre and multilobated, 20 microns or greater: nucleoli prominent, chromatin clumped. EXTENT OF INVASION
+
+--- Page 2 ---
+Primary Tumor: pT2: Tumor more than 7 cm in greatest dimension. limited to the kidney Regional Lymph Nodes: pNX: Cannot be assessed Lymph Nodes: None submitted. Distant metastasis: pMX: Cannot be assessed Margins: Margins uninvolved by invasive carcinoma. Adrenal gland: Uninvolved by tumor Venous invasion:Absent. Additional Pathologic Findings: None identified. Clinical: Right renal tumor.. Gross: The specimen is received fresh labeled with the patient's name and "right kidney." It consists of a right kidney with attached perinephric adipose tissue that measures 16 x 9 x 5.5 cm. A segment of ureter is present and measures 3.5 cm in length. An adrenal gland is present and measures 3.5 x 2 x 1 cm. A probe is passed into the ureter and the ureter is opened longitudinally to the pelvis. The kidney is then bivalved through the pelvic caliceal system. A tumor that measures 7.2 x 6 x 3 cm is present in the upper pole of the kidney. The cut surface of the tumor is partially maroon brown and partially tan. Tumor invasion into the perinephric adipose tissue is not identified. Invasion of the renal the ureter and pelvis are unremarkable. The adrenal gland is serially sliced and no abnormalities are noted. Representative sections of the specimen are submitted as follows: A = sections of the ureteral. renal vein and renal artery margins, B-E = representative sections of tumor in relation to perinephric fat and adjacent renal parenchyma. F = section of grossly uninvolved renal parenchyma, G = representative sections of adrenal gland. H-K = representative sections of hilar and perinephric fat containing possible nodes, L =  additional sections of distal ureter. M-Q = additional sections of tumor with capsule.
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diff --git a/output/text/22e278b7-01df-424c-a056-e88c18aa36c4.txt b/output/text/22e278b7-01df-424c-a056-e88c18aa36c4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e5d30872bec2fb098b172c138a762c9d7eaacba6
--- /dev/null
+++ b/output/text/22e278b7-01df-424c-a056-e88c18aa36c4.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+Specimen(s) Received 1. Lymph-Node: level 4, rt neck 2. Lymph node: level 1 lymph node Rt neck 3. Oral Cavity: Rt longue base QS 4. Oral Cavity: left vulecula QS 5. Oral Cavity: teft lateral pharynx QS 6. Oral Cavity: left lateral floor of mouth 7. Oral Cavity: Rt posterior tongue base.QS 8. Oral Cavity: near total glossectomy 9. Neck: bilateral neck dissection 10. Lymph node: Rt penfacial node 11. Lymph node: Rt penfacial node 12. Surgical Waste: surgical waste Diagnosis 1. Lymph node; level IV, right neck: -- Three lymph nodes, negative for tumor (0/3). 2. Lymph node; level I; right neck: - One lymph node, negative for tumor (0/1).. 3. Oral cavity; right tongue base: - Skeletal muscle, negative for tumor. 4. Oral cavity; left vallecula: - Squamous mucosa, negative for tumor. 5. Oral cavity; left lateral pharynx: - Squamous mucosa, negative for tumor.. 6. Oral cavity; left lateral floor of mouth: - Squamous mucosa and skeletal muscle, negative for tumor. 7. Oral cavity; right posterior tongue base:. - Squamous mucosa and skeletal muscle, negative for tumor. 8. Oral cavity resection; near total glossectomy: - Squamous cell carcinoma, moderately differentiated. 3.  Maximum tumor dimension 6.5 cm b. Maximum tumor thickness 2.2 cm. Page 1 of 4
+
+--- Page 2 ---
+Surgical Pathology Consultation Report C. No perineural invasion present..  No lymphovascular invasion present. d. e. Tumor is present at the infero-anterior margin.  Tumor is close (0.1 - 0.2 cm) to left oropharynx and deep soft tissue margins. g.Tumor is close (0.3 - 0.4 cm) to medial tongue, deep floor of mouth and postero-lateral floor of mouth margins.. 9. Bilateral neck dissection (see comment):. - Metastatic squamous cell carcinoma in five of twenty-five lymph nodes in right neck (5/25).. i. Largest involved lymph node measures 1.0 cm. ii. Involved lymph nodes are in levels IB, II and III.  ii.  No extracapsular extension present. - Metastatic squamous cell carcinoma in four of thirty lymph nodes in left neck (4/30).. iv. Largest involved lymph node measures 1.9 cm. V. Involved lymph nodes are in levels I8 and II.. vi.  No extracapsular extension present. - Right and left submandibular glands with no pathologic changes. 10. Right perifacial lymph node:. - One lymph node, negative for tumor (0/1). - Fragment of parotid tissue with no pathologic changes. 11. Right perifacial lymph node:. - One lymph node, negative for tumor(0/1) 12. Surgical waste: - Fibroadipose tissue and skin with no pathologic changes (gross examination only). Synoptic Data Specimen Type:e Resection:Near total glossectomy. Tumor Site: Tongue Histologic Type:. Squamous cell carcinoma, conventional Tumor Size: Greatest dimension: 6.5 cm Tumor thickness: 2.2 cm Histologic Grade: G2: Moderately differentiated Venous/Lymphatic (Large/Small Vessel) Invasion (V/L): Absent Perineural Invasion: Absent Additional Pathologic Findings:. Carcinoma in situ Margins: Margin(s) involved by tumor Location(s): infero-anterior Pathotogic Staging (pTNM): pT3: Tumor or lip or oral cavity more than 4 cm in greatest dimension pN2c: Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension for all aerodigestive sites except nasopharynx Number of regional lymph nodes examined: 55 Number of regional lymph nodes involved: 9 Extra-capsular extension of nodal tumor: Absent. pMX: Distant metastasis cannot be assessed Comment All nine positive lymph nodes in the bilateral neck dissection contain micrometastases only. The size of the largest node in each neck is based on the node size and not the size of the metastasis. Page 2 of 4
+
+--- Page 3 ---
+Surgical Pathology Consultation Report Clinical Historye oral ca Gross Description 1. The specimen is labeled with the patient's name and "level IV, right neck". It consists of portion of fibroadipose tissue.  measuring 1.7 x 1.4 x 0.3.cm. Multiple lymph nodes ranging from 0.3 x 0.2 x 0.2 cm to 0.6 x 0.5 x 0.3 cm are identified.. Representative sections are submitted. 1A two lymph nodes 1B one lymph node bisected 2. The specimen is labeled with the patient's name and "level I lymph node right neck". It consists one lymph node measuring 0.2 x 0.2 x 0.2 cm. 2A submitted in toto 3. The specimen is labeled with the patient's name and as "right tongue base gs'. It consists of a fragment of tissue measuring 1.1 x 0.5 x 0.3 cm. The specimen is submitted in toto for frozen section.. 3A frozen section control 4. The specimen is labeled with the patient's name and as "left vallecula qs ". It consists of a fragment of tissue measuring 0.9 x 0.4 x 0.2 cm. The specimen is submitted in toto for frozen section.. 4A . frozen section control 5. The specimen is labeled with the patient's name and as "left lateral pharynx qs". It consists of a fragment of tissue. measuring 1.4 x 0.3 x 0.3 cm. The specimen is submitted in toto for frozen section. 5A  frozen section control. 6. The specimen is labeled with the patient's name and as "left lateral floor of mouth gs". It consists of a fragment of tissue measuring 1.2 x 0.3 x 0.3 cm. The specimen is submitted in toto for frozen section.. 6A frozen section control. 7. The specimen is labeled with the patient's name and as "right posterior tongue base qs'. It consists of a fragment of tissue measuring 0.9 x 0.4 x 0.3 cm. The specimen is submitted in toto for frozen section.. 7A frozen section control 8. The specimen is labeled with the patient's name and as "near total glossectomy'. It consists of a large portion of left tongue measuring 5.0 cm SI x 3.5 cm ML x 8.5 AP. There is no suture orientation. There is a large endophytic tumor involving the lateral surface of the tongue. The tumor measures 4.0 cm Sl x 2.2 cm ML x 6.5 cm AP. The tumor is solid and tan with a nodular/papillary like component. It appears grossly to be located at 0.2 cm from the deep lateral floor of mouth mucosal margin, 0.5 cm from the medial margin, < 0.1 cm from the deep margin, abuts the left infero-anterior margin, and 0.5 cm from the posterior margin. The remaining tongue mucosa shows a yellowish white tiny 0.2 cm nodule at the postero lateral tongue margin. Representative sections are submitted. 8A left infero anterior margin 8B deep floor of mouth mucosal margin 8C postero lateral deep floor mouth mucosal margin 8D left oropharynx mucosal margin 8E posterior tongue margin 8F medial tongue margin 8G deep soft tissue margin 8H, 8I tumor 9. The specimen is labeled with the patient's name and "bilateral neck dissection". It consists of an oriented modified bilateral neck dissection with overall dimensions of 15 x 9 x 1.5 cm. The specimen is oriented on a green towel as right. and left levels I through IV. The internal jugular vein is not identified. No sternocleidomastoid is identified. The right submandibular gland measures 3.5 x 2.5 x 1.2 cm and is unremarkable. The left submandibular gland measures 3.0 x 2.0 x 1 cm and is grossly unremarkabie. Multiple lymph nodes ranging from 0.2 x 0.2 x 0.1 cm to 2 x 1 x 0.8 cm are identified in multiple levels. Representative sections are submitted. Page 3 of 4
+
+--- Page 4 ---
+Surgical Pathology Consultation Report 9A right submandibular gland 9B, 9C right level IB multiple lymph nodes each block 9D right level IB one lymph node bisected 9E, 9F right level II multiple lymph nodes each block 9G, 9H right levei II one lymph node bisected each block 9I right level Ill multiple lymph nodes.. 9J right level III two lymph nodes 9K right level IV two lymph nodes 9L left submandibular gland. 9M, 9N left level IB one lymph node bisected each block 9O left level IB multiple lymph nodes 9P left level II one lymph node bisected. 9Q, 9R left level II multiple lymph nodes 9S left level III multiple lymph nodes 9T left level IV multiple lymph nodes. 9U level IA multiple iymph nodes 10. The specimen is labeled with the patient's name and as "right penfacial node". It consists of one lymph node measuring 0.5 x 0.4 x 0.2 cm. 10A submitted in toto 11. The specimen is labeled with the patient's name and as "right penfacial node". It consists of one lymph node measuring 0.8 x 0.7 x 0.3 cm. 11A submitted in toto 12. The specimen is labeled with the'patient's name and as "surgical waste". It consists of three pieces of fibroadipose tissue and two pieces of tan skin received in 10% buffered formalin. The skin measures 2 x 1 x 0.3 cm and 4.5 x 3.5 x 0.2 cm and the largest piece of fibroadipose tissue measures 3 x 2 x 1.3 cm. No gross abnormality is noted. No sections are submitted for histologic examination. Quick Section Diagnosis 3. right tongue base: negative for malignancy. 4. left vallecula: negative for malignancy. 5. eft lateral pharynx: negative for malignancy. 6. left lateral floor of mouth: negative for malignancy. 7. right posterior tongue base: negative for malignancy. Page 4 of 4
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diff --git a/output/text/23040455-2f03-4d3a-91d9-29b2cc7384a1.txt b/output/text/23040455-2f03-4d3a-91d9-29b2cc7384a1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..cace01dc8644b4c4804e4540d72175b57e588397
--- /dev/null
+++ b/output/text/23040455-2f03-4d3a-91d9-29b2cc7384a1.txt
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+
+--- Page 1 ---
+SURGICAL PATHOLOGY Diagnosis: Kidney, left, partial nephrectomy Histologic tumor type/subtype: papillary renal cell carcinoma, type 2 Sarcomatoid features: not identified Histologic grade (if applicable): Fuhrman nuclear grade 2 (of 4) Tumor size (greatest dimension): 8.5 cm Tumor focality: focal Extent of tumor invasion (if present specify if macroscopic or microscopic):  Capsular invasion/perirenal adipose tissue: absent Gerota' s fascia: absent Renal sinus: not applicable Major veins (renal vein or segmental branches, Ivc): not applicable Ureter: not applicable Venous (large vessel): absent Lymphatic (small vessel): absent Histologic assessment of surgical margins: Renal parenchymal margin (partial nephrectomy only): negative Renal capsular margin (partial nephrectomy only): negative Paranephric adipose tissue margin (partial nephrectomy only): negative Gerota' s fascia (nephrectomy): not applicable Renal vein (nephrectomy): not applicable Ureter (nephrectomy): not applicable Adrenal gland: not submitted Lymph nodes: none identified AJcC Staging: pT2 pNx
+
+--- Page 2 ---
+This staging information is based on information available at the time of this report, and is subject to change pending clinical review and additional information. inical History:. -year-old male with a left renal mass. Gross Description: Received is one appropriately labeled container, additionally labeled "left kidney" and is a 159.8 gram 8.5 x 7.3 x 5.5 cm circumscribed soft nodule, partially covered with a predominantly intact capsule with a 1.3 cm irregular area of disruption. The exposed parenchymal margin is 5.7 x 5.2 cm and is inked black. The intact capsule is inked blue. Sectioning demonstrates a solid soft golden yellow/tan cut surface abutting blue and black inked capsular and parenchymal margins, respectively. It also communicates with the orange inked previously described defect. No cystic component is identified. There is a rim of renal parenchyma along the black inked surgical margin. There is a small amount of attached perinephric fat. The renal tissue at the periphery grossly appears unremarkable. Block Summary: Inking: capsule/blue, parenchyma/black, defect/yellow Al - tumor in relationship to black inked parenchymal margin A2-A3 - tumor and overlying capsule A4 - edge of defect A5-A6 - central tumor
\ No newline at end of file
diff --git a/output/text/230e097d-527a-4af7-b458-fda134d68b04.txt b/output/text/230e097d-527a-4af7-b458-fda134d68b04.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e60a0ff3864a576684d9fb539c6f2e233ac82c8a
--- /dev/null
+++ b/output/text/230e097d-527a-4af7-b458-fda134d68b04.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+TCGA-A6-2671 SPECIMEN Left colon CLINICAL NOTES PRE-OP DIAGNOSIS: Sigmoid colon GROSS DESCRIPTION Received fresh, subseguently fixed in formalin, labeled. "left colon" is a 22 cm long portion of colon.' The. specimen is intact, partially covered with pink-tan, smooth glistening serosa and abundant yellow lobular fat. The specimen is unoriented. One end is inked blue and the opposite end is inked black. The serosa is pink-tan smooth glistening and is partially covered with abundant yellow lobular fat. The specimen is opened to show a pink-tan, smooth glistening mucosa with an average. circumference of 5.5 cm. The specimen shows a 3.7 x 2.5 x 0.7 cm exophytic lesion which comes within 4.5 cm of the nearest luminal margin. The cut surface of the tumor shows invasion through the muscularis propria, and continuity with serosal puckering. There is invasion into the fat, coming within less than 1 cm of the radial margin. The remainder of the mucosa is pink-tan, smooth glistening with normal folds, having an average circumference of 5.5 cm. Lymph nodes are grossly identified. Representative sections submitted as follows: Block 1 - representative luminal margin; block 2 - tumor to normal and serosal umbilication; block 3 - representative section of tumor to fat and radial margin; block 4 - representative section of tumor to radial margin; blocks 5 and 6 - possibly mottled lymph node subjacent to tumor; block 7 - five possible lymph nodes subjacent to tumor; block 8 - nine possible lymph nodes; block 9 - four possible lymph nodes; black 10 - five possible lymph nodes; block 11 - six possible lymph nodes. Rs-6. GROSS DESCRIPTION
+
+--- Page 2 ---
+MICROSCOPIC DESCRIPTION Histologic type: Adenocarcinoma Histologic grade: Moderately-differentiated Primary tumor: pt3 (carcinoma extends through the muscularis propria, to less than 1 mm fron the serosal surface, which is not directly involved. Proximal margin: Negative. Distal margin: Negative. Circumferential (radial) margin: negative; carcinoma is less than mm from the radial margin. Vascular invasion:  Probable Regional lymph nodes (pN): Metastatic carcinoma in three of 27 1ymph nodes (3/27). Non-lymph node pericolonic tumor: four tumor nodules without associated lymphoid tissue identified. 5 DIAGNOSIS Colon, sigmoid, segmental resection: Adenocarcinoma, moderately differentiated. - Carcinoma invades through the muscularis propria into the subserosal fat (pT3). - Margins negative (carcinoma less than 1 mm from the radial margin).  Metastatic carcinoma in three of 27 lymph nodes (3/27). - Non-lymph node pericolonic tumor deposits present within the serosal fat (four nodules). DIAGNOSIS
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diff --git a/output/text/23367f48-5005-4157-8aaa-3694285450c9.txt b/output/text/23367f48-5005-4157-8aaa-3694285450c9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b2ae9b7e69ff0dff07ae3e5c83a83be40185f941
--- /dev/null
+++ b/output/text/23367f48-5005-4157-8aaa-3694285450c9.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Pathology Report DIAGNOSIS (A) LEFT KIDNEY AND ADRENAL: CHROMOPHOBE RENAL CELL CARCINOMA, EOSINOPHILIC TYPE, FUHRMAN'S NUCLEAR GRADE 3 TUMOR CONFINED TO THE KIDNEY. TUMOR MEASURES 12.0 CM IN MAXIMUM DIMENSION. Ureteral and vascular margins, free of tumor. Adrenal gland, no tumor present. (B) RETROPERITONEAL LYMPH NODE: Lymph node with atypical follicular hyperplasia. (See comment) COMMENT The immunohistochemical studies are pending. An addendum report will be issued by Dr. , a hematopathologist, when these results become available. GROSS DESCRIPTION (A) LEFT KIDNEY AND ADRENAL - A radical nephrectomy specimen and attached perinephric fat tissue (overall 26.0 x 13.0 x 8.0), including kidney (14.0 x 9.5 x 7.0 cm), unremarkable ureter (10.0 cm in length and. 0.4 cm in diameter), adrenal gland(6.0 x 2.0 x 1.5 cm). A well-defined, soft, mahogany brown tumor (12.0 x 8.5 x 7.0 cm) is Iocated at the mid pole. A central scar is present. a central. tan-yellow soft possibly necrotic focus measuring 1.5 x 1.0 cm is also identified. The tumor does not appear to involve the perirenal fat and sinus. The pelvis and ureter appear unremarkable. The rest of the renal parenchyma appears unremarkable. An. unremarkable adrenal gland is located superomedially INK CODE: Black - soft tissue margin. SECTION CODE: A1, vascular and ureteral margin; A2, A3, sinus and. tumor; A4, tumor and perinephric fat; A5, A6, central scar and necrosis;. A7-A10, representative sections of tumor; A11, A12, tumor and normal kidney; A13, tumor; A14, normal kidney; A15, adrenal gland. RT/elk (B) RETROPERITONEAL LYMPH NODE - A tan-yellow hemorrhagic matted lymph node measuring 12.3 x 3.0 x 1.5 cm. The specimen is serially sectioned. and entirely submitted in B1-B20. CLINICAL HISTORY Left renal mass.. SNOMED CODES
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diff --git a/output/text/2343a2e6-eda2-422c-8362-a5ecf7e977c1.txt b/output/text/2343a2e6-eda2-422c-8362-a5ecf7e977c1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4395cbe808b15bed0a3d03c3b03fd97b994abdc0
--- /dev/null
+++ b/output/text/2343a2e6-eda2-422c-8362-a5ecf7e977c1.txt
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+
+--- Page 1 ---
+UUID:0F1DC8BC-5987-4C50-9A34-79FFC1D2BA30 TCGA-C8-A26W-01A-PR Redacted IRB APPROVED MULTI-meDIa Sy*e Form Reviset Clinical Case Report. JCs-o-3 (For Collection of Cancerous Tissue) Carcinoma, mfItratmy duct;N0S 8500/3 Site: breot, Nos c5o.9 2 Informed Consent I personally informed this patient that a specimen(s) would be collected to be used for research purposes.I reviewed the. .. RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Signature Date Name of Physician or Study Coordinator Clinical Information MAGENERALINEORMATION Marital Status Race Temperature Date of Birth (mm/dd/yyyy). Height  Single Married Weight  Widow Blood Pressure Heart Rate Gender  Divorced  Male Female MHISTORYOEPRESENT ILLNESS Symptoms: Clinicat Findings: Performance Scale (Karnofsky Score): 60-70 Symptomatic, in bed less than 50% of day  100 Asymptomatic  80-90 Symptomatic but Fully Ambulatory  20-30 Bed Ridden  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden MOL CURRENTMEDICATIONS Date (mm/dd/yyyy) Dose Route Frequency Drug / To To To To To
+
+--- Page 2 ---
+.. PAST MEDICAL HISTORY  Diagnosis Date Status Diagnosis/Disease/Disorder/Injury Treatment OBGYNHISTOR  Date of First Menses # of Pregnancies Menopausal Status 02  Pre-menopausal yeay dl d Date of Last Menses. # of Live Births  Peri-Menopausal jd 0 2 -p Post-menopausal Fear? Birth Control:  Condom  Oral Contraceptive PIUD  Hormone Replacement  Other: Therapy: SOCAEHISTORY Occupation: Environmental Hazards: Smoking History Type  Packs/day Duration When Quit Current Status (yrs) (y).  YES NO Alcohol Consumption Type.  Drinks/day  Duration When Quit Current Status (yrs) (yr)  yes NO Drug Use Type Duration When Quit Current Status. Frequency (yrs) ( YES NO FAMILYMEDICALHISTORYM Age of Diagnosis Diagnosis Relative LABDATA  Result Date Date Test Test  Result CEA  Negative  Positive: HIV wNegative  Positive: CA 15-3   Negative  Positive: Hep B Negative  Positive: 1  CA 19-9   Negative  Positive: Hep C Negative  Positive: PSA   Negative  Positive: AFP  Positive:  Negative Other: Other:  Negative  Positive:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+Qr1.DIAGNOSTICSTUDIES:+CO Date  Results Study Ultrasound X-Ray CT Endoscopy MRI Biopsy beat cone DEMCLINICALDIAGNOSIS S  Preoperative Clinical Diagnosis Location of Suspected Distant Metastasis Location of Suspected Involved Lymph Nodes Date of Diagnosis Clinical Staging TZ Nl MO Stage: IB Treatment Information USKSURGICAETREATMENTED Date of Procedure Procedure Moditied Radical Masteiwms Primary Tumor Size Detailed Location Organ [zyppR crTeR quac/eonZ+3 x 2 x 2 cm BReasT ZumeR Extension of Tumor Lymph Nodes # of Lymph Nodes. Location of Lymph Nodes Description  Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Size Detailed Location Organ Surgical Staging NAM2 Stage: t 2 NEOADJUVENTTHERAPY (ChemoRadiationImmunoHormonal orMolecular Date (mm/dd/yyyy)  Route Freguency Dose Drug/Treatment To To / To To To 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Date: Collected by: me Preserved by: Date: SPECIMENTYPE# f samp provided*** : Paraffin Block  Blood/Serum/Plasma  Slide Frozen Diseased Normal Diseased Normal Diseased Normal Diseased  Normal Time to Formalin Time to LN2 Time to LN2 12 min 13. min min WT APATHOLOGICAEDESCRIPTIONAHRR Primary Tumor Organ Size Extension of Tumor  Distance to NAT 3 x 2 x 2 cm|eppe cre/ee qud/zm 6 Breast Jumek  cm Lymph Nodes # Examined # Metastasized Location Distant Metastasis Detailed Location Size Organ Pathological Staging pT zN/ I M o Stage: T Notes: ( M1 p87ice iM2 veFati've )
+
+--- Page 5 ---
+COnsOLIDateD DiagnOstic pathoLOgy fOrm* Microscopic Appearance:d 1. Histological pattern: CELL DISTRIBUTION Diffuse STRUCTURAL PATTERN Mosaic Streaming Necrosis  Storiform Lymphocytic Infitration IX  Fibrosis Vascular Invasion Palisading Clusterized Cystic Degeneration A Aiveolar Formation Bleeding Indian File x Myxoid Change 2. Cellular features: Psammoma/Calcification Sqwamous Adenomatous Squamoid Cell Sarcomatous Glandular cell Lymphomatous Spindle Cell Round Cell Cell Stratification Large CeH Fibroblast Keratin Secretion Small Cell Desmosome Osteoblast Intracy. Vacuoke  RS CeIVRS Like Lipoblast Pear! Inflam. Cell Gland formation  Myoblast Otherwise Specified: Plasma Cell D s02 S240 4U) i%QQ(ro: 2.Cellular Differentiation: Well Moderaxety Poor CX 3. Nnclear Atypia: Nuckar Appearance Aniso Nuclcosis Hyperchromatism Nucleolar Prominent Multinuclcated Giant Cel! Mitotic Activity Nuckear Grade Histological Diagnosis: spltaiy AAeta ClMMmg, N  62 Comments:hsi : COoUyre mltoetesired to CN n n Mr: orrnr  Lijdy)aqeits- Director, Research Pathology T STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AN
+
+--- Page 6 ---
+Microscopic Description tr.Histological Pattern.w Cell Distribution + Structural Pattern +  Streaming Diffuse Mosaic Storiform  Necrosis Fibrosis Lymphocytic Infiltration x  Palisading Vascular Invasion Cystic Degeneration Clusterized Bleeding Alveolar Formation Myxoid Change Psammoma/Calcification Indian File eCellularDifferentiation  Adenomatous Sarcomatous + Lymphomatous + Squamous +I- +  Glandular cell Round Cell Large Cell Squamoid Cell  Cell Stratification Fibroblast Small Cell Spindie Cell  RS Cell/RS Like Keratin  Secretion Osteoblast Inflam. Cell  Desmosome Intracyt. Vacuole  Lipoblast Myoblast Plasma Cell Pear! Gland formation Well Moderate  Poor Cellular Differentiation: + wwNuclear Appearancewwys 0 I II III Nuclear Atypia:  Aniso Nucleosis Hyperchromatism  Nucleolar Prominent Multinucleated Giant Cel  Mitotic Activity Nuclear Grade: Value Date Marker  Result ER Negative Positive PR  Negative  Positive Her-2/neu Negative  Positive  Positive B-Cell Marker Negative  Negative  Positive T-Cell Marker  Negative  Positive Other: Other: Negative  Positive Final Pathology Report tAhiltratieg duett caecinoms Histological Diagnosis: Grade:_ f MoceRate (y digeerco Aated) Comments: Date  Pathologist Principal Investigator 5
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diff --git a/output/text/236dd483-b807-4c1e-9a7e-981e7f1e47da.txt b/output/text/236dd483-b807-4c1e-9a7e-981e7f1e47da.txt
new file mode 100644
index 0000000000000000000000000000000000000000..06017ca661318ebca61d7068888ac8013fd6f44c
--- /dev/null
+++ b/output/text/236dd483-b807-4c1e-9a7e-981e7f1e47da.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+JUID:731F15DB-25D3-41AS-AEA5-4C96F1249ABA TCGA-MQ-A4LC-01A-PR Redacted Result type: Report Result date: Resuit status: Auth (Verified)  Result title: SPECIMEN DESCRIPTION Performed by: * Final Report * SPECIMEN DESCRIPTION 1cs-0-3 LEVEL NO 7 LYMPH NODE TUMOR RIGHT LUNG Mortheli'omr, epitheliorL,N05 9053f3 RIGHT LUNG LEVEL NO 8 LYMPH NODE Sit:Plurs,Nvs c38.4 lw LEVEL NO 9 LYMPH NODE 10/4f13 DIAPHRAGMATIC TUMOR LEVEL NO 4 LYMPH NODE 6TH RIGHT RIB FOR SURGICAL PATHOLOGY REPORT LOCATION : PATHOLOGY NO.: HOSPITAL ID: HOSPITAL NO.: PATIENT'S NAME: ACCOUNT NO.: AgE/SEX/DOB: M DATE RECEIVED: PHYSICIAN (S) : DATE OF PROCEDURE: COPY TO: ACCN REQ. NO.: NOT GIVEN DIAGNOSIS: A. LEVEL VII LYMPH NODE, EXCISION: ELEVEN LYMPH NODES NEGATIVE FOR MALIGNANCY. B.  RIGHT LUNG, TUMOR EXCISION: MALIGNANT MESOTHELIOMA, TUBULOPAPILLARY TYPE. C.  RIGHT LUNG, EXTRAPLEURAL PNEUMONECTOMY: MALIGNANT MESOTHELIOMA, EPITHELIAL, TUBULOPAPILLARY TYPE, DIFFUSE. BRONCHIAL MARGIN NEGATIVE FOR TUMOR. LUNG PARENCHYMA FREE OF TUMOR. NINE HILAR LYMPH NODES NEGATIVE FOR MALIGNANCY. D. LEVEL VIII LYMPH NODE, EXCISION: THREE LYMPH NODES NEGATIVE FOR MALIGNANCY. E. LEVEL IX LYMPH NODE, EXCISION: ONE LYMPH NODE NEGATIVE FOR MALIGNANCY. Printed by: Page 1 of 4 Printed on: (Continued)
+
+--- Page 2 ---
+E.  LABELED DIAPHRAGMATIC TUMOR: MALIGNANT MESOTHELIOMA, EPITHELIAL,  TUBULOPAPILLARY TYPE, INVADING M FIBROCOLLAGENOUS TISSUE AND FOCALLY THE SKELETAL MUSCLE. G. LEVEL IV LYMPH NODE, EXCISION: FOUR LYMPH NODES NEGATIVE FOR MALIGNANCY. H. RIB, RESECTION: FOR GROSS ONLY. cOmmENr: The tumor present in specimens B, C and F is formed by epithelial. cells with eosinophilic cytoplasm round nucleus and prominent nucleoli. These cells are arranged in glands and form papilla as well as nests.  The immunohistochemical studies confirm the. diagnosis of malignant mesothelioma: the tumor cells are positive for. calretinin, thrombomodulin , wT-1, cytokeratin and negative for B72.3, cEA, and BEREP-4. LEVEL NO 7 LYMPH NODE SPECIMEN: A B TUMOR RIGHT LUNG c RIGHT LUNG D LEVEL NO 8 LYMPH NODE LEVEL NO 9 LYMPH NODE E DIAPHRAGMATIC TUMOR G LEVEL NO 4 LYMPH NODE H 6TH RIGHT RIB FOR OPERATION: R EXTRAPLEURAL PNEUMONECTOMY PRE-OP DIAGNOSIS: LUNG CANCER RT POST-OP DIAGNOSIS: SAME CLINICAL DATA: NOT GIVEN Gross DEscriprroN: The specimen is received in eight separate containers.. A. Received fresh labeled level 7 lymph node is one fragment of fibroadipose. tissue measuring 5.5 x 2.0 x 0.5 cm. Summary of sections: 1-- one lymph node bisected, 2- two possible lymph nodes, 3- one lymph node bisected, two lymph nodes bisected, 5 one lymph node bisected, 6 one lymph node bisected, 7-- one lymph node, 8--- one. I ymph node bisected. B. Received fresh labeled tumor right lung is one fragment of fibroadipose tissue measuring 2.0 x 1.0 x 0.2 cm. Entirely submitted in two cassettes. Printed by: Page 2 of 4 Printed on: (Continued)
+
+--- Page 3 ---
+C. Received fresh labeled right lung is a right extrapleural pneumonectomy x 15.0 x 4.0 cm.weighing 800 gm.tota1.  The parietal pleura is attached at the superior part of the specimen and measures 30 x 15 cm, with 0.2 cm thickness.  The thoracic, diaphragmatic, and mediastinal. surface of the lung is almost entirely covered by granular, tan indurated nodules.  The lung is serially sectioned. The lung's parenchyma is soft, red, and free of tumor, except at the mediastinal aspect of the lung where the tumor appears to invade the lung parenchyma. The parietal pleura also shows multiple nodules, the largest measuring 10 x 3 x 3 cm and appears to invade the lung. Summary of sections: 1&2-sections from the tumor, 3-bronchial margin with two lymph nodes,. -vesseis"with one nilar Iymph node,. 5-three possible lymph nodes, 6 -three possible lymph nodes, 7-tumor to lung parenchyma, 8&9-tumor and parietal pleura. 10-tumor. D. Received fresh labeled level 8 lymph node is a piece of tissue measuring 1.5 x 0.8 x 0.3 cm. Two lymph nodes are identified measuring 0.5 and 0.7 cm. Summary of sections: D1-- one lymph node bisected, D2- one lymph node bisected. E. Received fresh labeled level 9 lymph node is one lymph node measuring 1.0 x 0.5 x 0.2 cm. The specimen is bisected and entirely submitted in one cassette. F.  Received fresh labeled tumor diaphragmatic are multiple fragments of fibroadipose tissue with fibrous white granular tissue aggregating to S.0 x 5.0 x 1.0 cm. Representative sections are submitted in two cassettes.. G. Received fresh are two anthrocotic lymph nodes measuring 1.2 and 0.5 cm. Summary of cassettes: 1- one lymph node bisected, 2- one lymph node. H. Received fresh labeled ribs are six fragments of bone submitted for Dr.. study. CPT CODE: Printed by: Page 3 of 4 Printed on: (Continued)
+
+--- Page 4 ---
+ELECTRONIC SIGNATURE: Completed Action List: * Perform by Printed by: Page 4 of 4 Printed on: (End of Report)
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diff --git a/output/text/23721212-e03e-4c0c-b57f-8d1c9b6c560a.txt b/output/text/23721212-e03e-4c0c-b57f-8d1c9b6c560a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7ea61062e98c1b6885e0087bd9320b94a8b20a42
--- /dev/null
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+
+--- Page 1 ---
+TOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974S SURGICAL PATHOLOGY REPORT Patient: FMP/SSN: Specimen #: DOb/Age/Sex: F Race: wHITE Taken: Location: Received: Physician(s) : Reported: /es-0-3 Carcwiona, nifiAtrat7y outl, Nvs 850f3 AMENDED* * Site: brast, n0s C5v.9 124/1 SPECIMEN: A: SENTINEL LYMPH NODE #1 B: SENTINEL LYMPH NODE #2 C: RIGHT BREAST LUMPECTOMY UUID:DAB9A2B8-FCE7-4FF4-BAC4-4D2A04D7A43B TCGA-A2-A0CP-01A-PR FINAL DIAGNOSIS: Redacted A. SENTINEL LYMPH NODE #1, EXCISION: NEGATIVE FOR MALIGNANCY VIA LIGHT MICROSCOr1. NEGATIVE FOR MALIGNANCY VIA IMMUNOHISTOCHMICAL STAINS. B. SENTINEL LYMPH NODE #2, EXCISION: NEGATIVE FOR MALIGNANCY VIA LIGHT MICROSCOPY. NEGATIVE FOR MALIGNANCY VIA IMMUNOHISTOCHEMICAL STAINS. C. BREAST, RIGHT, LUMPECTOMY: WELL DIFFERENTIATED INFILTRATING DUCTAL CARCINOMA, BLOOM-RICHARDSON GRADE 4 (TUMOR SIZE= 2.0 CM), ANCILLARY STUDIES PENDING. DUCTAL CARCINOMA IN SITU, LOW NUCLEAR GRADE, CRIBIFORM PATTERN, LESS THAN 25% OF TUMOR VOLUME. MARGINS CLEAR OF DUCTAL CARCINOMA IN SITU AND INFILTRATING DUCTAL CARCINOMA. Comment : The Estrogen and Progesterone receptors are detectable in 40 and 80% of the tumor nuclei resepctively, by immunohistochemical protocol. ** Report Electronically Signed Out * CLINICAL DIAGNOSIS AND HISTORY: year-old white female with right breast cancer.. Page 1 Continued on Next Page. FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974S
+
+--- Page 2 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION: A. SENTINEL LyMPH NODE #1 received fresh is a piece of red soft tissue, 3.0 x 1.5 x 0.3 cm, containing at least one lymph node measuring 1.0 cm in greatest dimension. A small portion of the node is harvested for the cBcp protocol and submitted in cassette Al. The remainder of the specimen is submitted entirely in cassette A2.. B. sENTINEL LyMPH NODE #2 received fresh, labeled with the patient's name,. designated "sENTINEL NODE NUMBER TWO" is a soft, red tissue fragment, 2.3 x 1.7 x 0.3 cm, containing at least one lymph node, 0.7 cm in greatest. dimension. A small portion of the lymph node is submitted for the cBcp protocol in cassette B1. C. RIGHT BREAsT LUMPECTOMy received fresh, labeled with the patient's name, designated "RIGHT BREAST LUMPECTOMy" is a piece of fibrofatty tissue, 5.5 x 4.5 x 3.0 cm, with overlying skin ellipse, 3.0 x 0.9 cm. The. specimen is oriented with sutures and inked as follows: Blue-superior, green-inferior, red-lateral, yellow=medial, black-posterior. Sectioning reveals a 2.0 cm, well-defined tumor with a tan, gritty cut surface, approximately 0.2 cm from the superior-deep margin. Sections of skin, tumor, and fibrous tissue at 1.0 , 2.0, 5.0 cm increments from tumor are. submitted for the CBcp protocol (matching paraffin sections=c1, c2-c5, C6, c7, and c8, respectively). Page 2 End of Report FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974S
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diff --git a/output/text/2391ef83-0690-48ac-8bba-489b75d7c890.txt b/output/text/2391ef83-0690-48ac-8bba-489b75d7c890.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c26105832d515b3647f0535b8e4abe761cbe0e66
--- /dev/null
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+
+--- Page 1 ---
+UUID:CC77BA51-CE5A-4839-A27A-DD8F389A2733 Patient: Redacted AP Surgical Pathology: Additiona! Info. Surg Path CLINICAL HISTORY: Biopsy of known carcinoma right 10:00 breast. If invasive carcinoma, please obtain ER, PR, EGFR, HER2/Neu by immunohistochemistry; for all 2+ IHC results. please do Fish analysis. GROSS EXAMINATION: A. "usncb right breast, five cores 10:00 area". Received in formalin is a 1.7. x 1 x 0.2 cm aggregate of fibrofatty needle core tissue submitted entirely in a mesh bag in block Al. MICROSCOPIC EXAMINATION: Microscopic examination is performed. DIAGNOSIS: "USNCB RIGHT BREAST, FIVE CORES 1O:0O AREA": A. INVASIVE ADENOCARCINOMA OF THE BREAST. HISTOLOGIC TYPE: DUCTAL. NOTTINGHAM COMBINED HISTOLOGIC GRADE: 3 OF 3. icD-o-3 TUBULE FORMATION SCORE: 3. NUCLEAR PLEOMORPHISM SCORE: 3. Carcinoma, inF1tghinq ducta) NOs MITOTIC RATE SCORE: 3. y sooJ3 LYMPHATIC/VASCULAR INVASION: NOT IDENTIFIED.S Sik; bregst,n0s  c50,9 IN-SITU CARCINOMA: PRESENT. TYPE OF IN-SITU CARCINOMA: COMEDO. NUCLEAR GRADE OF IN-SITU CARCINOMA: 3 OF 3. 7-Z1Z MICROCALCIFICATIONS: ABSENT. ESTROGEN/PROGESTERONE RECEPTOR, HER2/NEU, AND EGFR ANALYSIS: PENDING.S PARAFFIN BLOCK NUMBER: A1. RESULTS WILL BE ISSUED IN AN ADDENDUM. I certify that I personally conducted the diagnostic evaluation of the above. specimen(s) and have rendered the above diagnosis(es).. Electronically signed:  ADDENDUM 1: for results of supplementary Please see tests. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es).. Electronically signed:4 Performed by: Attending MD: Ordering MD:
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diff --git a/output/text/23a30f65-7329-40da-acb8-2595b35393b9.txt b/output/text/23a30f65-7329-40da-acb8-2595b35393b9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..531954e9e69628768191a53391f61abe58f8c90e
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Surgery Date TCGA-CJ-4913 Pathology Report DIAGNOSIS (A) LEFT KIDNEY, ADRENAL AND PERIHILAR LYMPH NODES: rENAL CELL CARCINOMA, CONVENTIONAL (50% CLEAR CELLS AND 50% EOSINOPHILIC CELLS) WITH FOCAl RHABDOID CELLS, fUHrmAn'S NUCLEAR GRADE 4. TUmOR eXTenDs InTO ThE RENAl SinUS ADIPoSe TisSUE. Tumor measures 6.3 Cm In mAximum DimeNsion. VASCULAR/LYMPHATIC INVASION PRESENT. Vascular, ureteral and soft tissue margins of resection free of tumor.. Adrena! gland, no tumor present. GROSS DESCRIPTION (A) LEFT KIDNEY, ADRENAL GLAND AND PERIHILAR LYMPH NODES - A 19.5 x 11.5 x 5.7 cm nephrectomy specimen including a 13.8 x 8.0 x 5.3 cm kidney with attached 9.5 x 0.5 cm ureter and overlying 5.5 x 2.4 x 0.5 cm adrenal gland.. There is a 6.3 x 5.5 x 5.4 cm, well-circumscribed yellow-tan, hemorrhagic and necrotic tumor in the upper pole. The tumor is grossly appears to be confined to within the kidney but focally pushing the renal sinus adipose tissue. The renal pelvis and renal hilum is uninvolved by tumor, as well as is the renal vein, renal artery and renal ureter. The surgical margins of resection are free of tumor. No Iymph nodes are identified in the hilum of the kidney. Portions of tumor and normal parenchyma are submitted to tissue bank. Portion of tumor is submitted to possible electron microscopic studies. SECTiON CODE: A1, renal artery, renal vein and renal ureter margin (en face); A2, A3, representative sections of tumor in relationship. to renal pelvis/hilum; A4, A5, representative sections of tumor in relationship to overlying capsule; A6-A8, additional sectlons of tumor; A9, normal rena! parenchyma; A10, normal adrenal gland. CLInICAL HISTORy Mass, renal left. SNOMED CODeS T-71000, M-83123, T-B3000, M-00110
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diff --git a/output/text/241647c2-b1ce-4aef-901c-5b0e484f414e.txt b/output/text/241647c2-b1ce-4aef-901c-5b0e484f414e.txt
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index 0000000000000000000000000000000000000000..d0ba9b262211b728057be6ae91d17a67dcc2d45e
--- /dev/null
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+
+--- Page 1 ---
+UUID:14EB270E -0AAB-4C12-8D71-ED79076C2E93 TCGA-E2-A573-01A-PR Redacted SPECIMEN(S): A. RIGHT BREAST PARTIAL MASTECTOMY B. SLN #1 RIGHT AXILLA C. ADDITIONAL AXILLARY TISSUE RIGHT AXILLA CLINICAL HISTORY: This is a year old female with a 1.4 cm tumor in the right breast, IDC at 11:00. S/P benign MRI biopsy inferior and lateral to this index lesion, not clipped. Here for N/L 1umpectomy with SLN biopsy. INTRAOPERATIVE CONSULTATION DIAGNOSIS: A. Right breast, partial mastectomy: Tumor is 0.3 cm from anterior margin. TPB1-TPB4: SLN#1, right axilla, excision: Four lymph nodes, negative for carcinoma. Diagnosis called to Dr. at by Dr. 1cD-o-3 PRE-OPERATIVE DIAGNOSIS Chci on, hifilt^strNg duct,Nos 850f3 Right breast cancer Site: buwt, Nus c- 50.9 h 1/25/ GROSS DESCRIPTION: A. RIGHT BREAST PARTIAL MASTECTOMY Received fresh in a container labeled with the patients name and "right breast partial mastectomy' is an oriented (straight: superior- 1 clip, long: lateral - 2 clips, double: deep, air knot in axillary tail), previously inked, 130g, 11 x 9 x 3.5 cm partial mastectomy with accompanying radiograph. Ink code: anterior-yellow, posterior-black, medial-green, lateral-red, superior-blue, inferior-orange. The specimen is serially sectioned from superior to inferior into 8 slices revealing a 1.6 x 1.4 x 0.8 cm firm, circumscribed, tan mass that is closest to the anterior margin at 0.3 cm. Tissue is procured. Representatively submitted: A1: slice 1, superior margin A2-A3: slice 4, mass with skin and anterior margin, bisected. A4-A5: slice 4, posterior margin underlying mass, bisected A6-A7: slice 4, anterior and posterior margins, bisected. A8-A9: slice 4, lateral and posterior margins, bisected A10-A11: slice 4, anterior and medial margins, bisected A12-A13: slice 4, medial and posterior margins, bisected A14: slice 5, mass with skin and anterior margin. A15-A16: slice 8, inferior margin B. SLN #1 RIGHT AXILLA Received fresh labeled with the patients name and "SLN #1 right axilla' is a 5 x 2 x 0.7 cm aggregate of fatty tissue within which four lymph nodes, 2 x 0.6 x 0.6 cm, 2 x 1 x 0.6 cm, 2 x 1.1 x 0.4 cm, 1.2 x 1 x 0.6 cm are identified. Touch preps are performed. Lymph nodes are entirely submitted: B1-B2: one lymph node
+
+--- Page 2 ---
+B3: one lymph node B4: one lymph node B5: one lymph node C. ADDITIONAL AXILLARY TISSUE RIGHT AXILLA Received in formalin in a container labeled with the patients name and designated "additional axillary tissue" is a 1.7 x 1 x 0.2 cm fragment of soft fatty tissue. The specimen is bisected and entirely submitted. DIAGNOSIS: A. BREAST, RIGHT, PARTIAL MASTECTOMY: - INVASIVE DUCTAL CARCINOMA WITH LYMPHOPLASMACYTIC INFILTRATE AND GEOGRAPHIC NECROSIS, SBR GRADE 3, MEASURING 1.1-CM - SURGICAL RESECTION MARGINS NEGATIVE FOR TUMOR - BIOPSY SITE CHANGES WITH FIBROSIS AND FAT NECROSIS - SEE SYNOPTIC REPORT. B. LYMPH NODE, SENTINEL #1, RIGHT AXILLA, EXCISION: - FOUR LYMPH NODES, NEGATIVE FOR METASTASES (0/4). C. ADDITIONAL AXILLARY TISSUE, RIGHT, AXILLARY DISSECTION: - FIBROADIPOSE TISSUE, NO TUMOR OR LYMPHOID TISSUE IDENTIFIED. SYNOPTIC REPORT - BREAST Specimen Type: Partial mastectomy Needle Localization:  No Laterality:  Right Invasive Tumor: Present Multifocality: No WHO CLASSIFICATION Invasive ductal carcinoma, NOs 8500/3 Tumor size: 1.1cm Tumor Site: Upper outer quadrant Margins: Negative Distance from closest margin: 0.3cm anterior Tubular Score: 3 Nuclear Grade: 3 Mitotic Score: 2. Modified Scarff Bloom Richardson Grade: 3 Necrosis: Present Vascular/Lymphatic Invasion: None identified Lobular neoplasia: None Lymph nodes: Sentinel lymph node Lymph node status: Negative 0/4 DCIS not present
+
+--- Page 3 ---
+ER/PR/HER2 Results ER: Pending PR: Pending HER2: Pending Pathological staging (pTN): pT 1c N 0  Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition
+
+--- Page 4 ---
+ADDENDUM: SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimen: Surgical Excision Block Number:  A2 ER: Negative Allred Score: 0 = Proportion Score 0 + Intensity Score 0 PR: Negative Allred Score: 0 -- Proportion Score 0 + Intensity Score 0 COMMENT: The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11- 30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 - weak intensity of staining, 2 = intermediate intensity of staining, 3 - strong intensity of staining), with a scoring range from 0 to 8. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2. METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Immunohistochemistry was performed using the mouse anti-human ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) provided by following the manufacturer s. instructions. This assay was not modified. Interpretation of the ER/PR immunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal review of staining performance. SYNOPTIC REPORT - BREAST HER-2 RESULTS Specimen: Surgical Excision Block Number: A2 Interpretation: EQUIVOCAL Intensity: 2+ % Tumor Staining: 10% Fish Ordered: Yes METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Her2 analysis was performed using the FDA approved HercepTest (TM) test kit ising rabbit anti-human HER2. This assay was not modified. External kit-slides provided by the manufacturer (cell lines with high, low and negative HER2 protein expression) and in-house known HER2 amplified control tissue were evaluated along with the test tissue. Adequate, well preserved, clear-cut invasive carcinoma was identified for HER2 evaluation. Interpretation of the HER2 immunohistochemical stain is guided by published results in the medical literature,  information provided by the reagent manufacturer and by internal review of staining performance. This assay has been validated according to the  joint recommendations and guidelines from ASCO and CAP and from the NCCN HER2 testing in Breast Cancer Task Force. The Pathology Department takes full responsibility for this test's performance.
+
+--- Page 5 ---
+ADDENDUM: FISH/ISH ANALYSIS REPORT 3 Specimens Involved Specimens: A: RIGHT BREAST PARTIAL MASTECTOMY HER2/NEU RESULTS ANALYTICAL INTERPRETATION OF RESULTS HER-2 NOT AMPLIFIED Clinical interpretation of the results A majority of tumors cells displayed 2 chromosome 17 centimeter signals and 2 HER2 signals, with a HER2/CEP 17 Ratio 1.3, consistent with no amplification of the HER2/neu gene. Probes identification LSI Her-2/neu 17q11.2-12, spectrumorange CEP 17, 17 p11.1-q11.1 alpha satellite DNA, spectrumgreen Image analysis method - Manual Results interpreted Yes ISCN nuc ish: (CEP17,HER2)x2[200] Number of invasive tumor cells counted 200 Number of observers  Number of Her2 signals/nucleus 2.3  Number of CEP 17 signals/nucleus 1.8 Her2/CEP 17 ratio 1.3 TEST CHARACTERISTICS: PathVysion HER-2 DNA Probe Kit is FDA approved for selection of patients for whom Herceptin therapy is being considered. These tests were performed in the Pathology Core Facility, Department of Pathology, under the direction of Dr.. The results of these studies should always be interpreted in the context of the clinical, morphological, and immunophenotypic diagnosis. The PathVysion Kit is not intended for use to screen for or diagnose breast cancer. It is intended to be used as an adjunct to other prognostic factors currently used to predict disease-free and overall survival in stage II, node-positive breast cancer patients. In making decisions regarding adjuvant CAF treatment, all other available clinical information should also be taken into consideration, such as tumor size, number of involved Iymph nodes, and steroid receptor status. No treatment decision for stage II, node-positive breast cancer patients should be based on HER-2/neu gene amplification status alone. Specimen information RPCI surgical pathology/cytology case number Source of case RPCI Block number used A2 Specimen site Breast
+
+--- Page 6 ---
+Female breast right Specimen type Complete excision (less total mastectomy) Specimen fixative type Formalin Duration of fixation (hrs) 6 - 48 hrs Comment: Controls: The FIsH study was performed with appropriately stained positive and negative controls.
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diff --git a/output/text/242e18ca-a8ce-4767-b51b-fa5f6af8c0ed.txt b/output/text/242e18ca-a8ce-4767-b51b-fa5f6af8c0ed.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a4e00f392f85cac3e7e4603e8f4c65715c6aeab8
--- /dev/null
+++ b/output/text/242e18ca-a8ce-4767-b51b-fa5f6af8c0ed.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:5F310E76-71F2-4E9E-83D1-85B05BDB5018 TCGA-A4-A57E-01A-PR Redacted Dx.a D.O.B.: MRN# Ref Phy PECIMENINFORMATION Collected: Accessian #: Received: Reported: SURGICAL PATHOLOGY REPORT DIAGNOSIS: Left kidney and adrenal gland: Tumor Characferistics: 2. Tumor site: Upper lobe of left kidney. 3.Tumor focallty:Unifocal. 4.Tumor size:7.5 x 6.0 x 5.8 cm 5. Macroscopic extent of tumor: Neoplasm appears to be confined to the contents of the kldney.. 6. Microscopic extent of tumor: Neoplasm does not appear to invade through the renai capsule.. 7. Nuclear grade: Fuhurman grade 3/4. 8. Lymphovascular space invasion: No. 9. Sarcomatoid features: Absent. zcD6-3 Surgicat Margin.Status: 1. Margins are uninvolved by carcinoma 2. Ureteral margin: Negative. arenomc, pop llary : renal ce)! 3. Soft tissue margins: Negative. 8260|3 4. Vascular margins: Negative. Site: OKidney, Nos Lymph Node Status: 1. Total number of lymph nodes received: 1 (hilar). 2.Tatal number of lymph nodes containing metastatic carcinoma: 0. C64.9 Other: 9D 1215112 1. Other significant findings: Adrenal gland: Metastatic renal cell carcinoma. (see comment) Chronic pylonephritis.. 2. pTNM stage:T2a N0 M1. Electronic signature. COMMENTS: Sections of the adrenal giand demonstrate adrenal cortical hyperplasia with extensive hemorrhage and focal necrosis within the medullary component. A single nodule of clear cell proliferation which is well vascularized is noted and because of the histologic features immunohistochemical stains are. periormed with the following results: RCC: Positive. CDt0: Positive. Vimentin: Positive. Based on the immunohistochemical results and the H&E findings the features of the adrenal nodule are most consistent with those of metastatic rena! s carcinoma. This case has.been reviewed in intradepartmental consultation and as part of the Department's Quallty Review Program b!.. e in agreement with the diagnosis. CLINICALHISTORY: Preoperative Diagnosis: Abdominal mass unspecified site.. Postoperative Diagncsie: Symptoms/Radiologic Findings SPECIMENS: Left kidney and adrenal gland.
+
+--- Page 2 ---
+GROSS DESCRIPTION: The specimen is received labeled  measures 20 x 14 x 10 cm., weighs 1,045 grams. Thers is a portion of adrenal giand attached to the specimen as well as a detached piece of an. adrenal gland within the container. The adrenal gland together measures 4.5 x 2 x 2 cm. The cut surface is golden yellow with areas of hemorrhage.. The ureter measures 9.5 cm. in length, 0.3 cm. in diameter. The surface is gray to brown-tan. The ureter is opened. The mucosal surface is light tan. There is no material within the lumen or lesions identified. The renal artery measures 1.5 cm. in length, 0.5 cm. in diameter. it Is grossly unremarkable. The renal vein measures 1.5 cm. in diameter. Sectioning there is tumor visibla within the lumen, it is 0.6 cm. from the resected margin.. At the hllum there is a yellow-tan nodule measuring 1 x 1 x 0.5 cm. possible lymph node. The soft tissue resection margin is yellow-tan slightly shaggy. The resected margin has been inked. The kidney is bisected and reveals a yellow to brown-tan variegated soft friable shaggy mass measuring 7.5 x 6 x 5.8 cm. within the upper pole that on sectoning is grossly confined to the capsule and does not show evidence of invasion into the perinephric fat. It comes within 0.1 cm. of the inked resected nargin. The mass does not invoive the surrounding renal calices pelvis. The calices, peivis are gray-tan.. The surrounding renal cortex is brown-tan and measures 0.5 cm. and shows a well demarcated corticomedullary junction. No other lesions are identified grossly.  Received with the specimen are three cassettes - one green, one yellow, one blue labeled. vith the yellow cassette additionally labeled.-. 16. The green cassette additionally labeled - 17; and the blue cassette additlonally labeled - 18. Representative sections are submitted in cassettes labeled -- Iolows: sections from mass in blocks 1 through 4; ureter block 5; rena!  artery and vein in block 6; surrounding uninvolved kidney in olock 7: possible hilar lymph node bisected in block 8; adrenai gland in block 9..
+
+--- Page 3 ---
+Vs.m. TCGA Pathologic Diagnossis Discrepancy Form Inst ructions: The TCgA Pathologic Diagnosis Discropancy Fom shouid ht completed whien the pathologic diagnosis doct mented on the initial pathology report for a case submited for TcgA is inconsistent with the diagnosis provided on the Gast Quality Control Form completed for the submitted cuse. -TSs Identifier: A. rss Unique Patient Identitier: - Tisst:e Source Site (TSS):. Com 3leted By (incerviuwar Name on OpenClinico). Completed Date:. Diay nosis Information Entry Alternadves Working Instructinns Data Element Provide tho diagnosis/ histologit suntype(s) documented on Pathulogic Diagnosis Renal_Cell Carginoms.. this cas is mixed provide all isted subtypes. Providcd on Initia. Pathology Report pael Pravido the histologic fe stures sclec ed on the rCGA Case Histologic reatures of Papiliarn Rena) CcllCare inum Quality Control.Form conpirted for this case. tho.sample provided Yor TCGA, as reflecred on the CQCr: . Dis repancy between Pathology Report and Case Quality Control Forint Provide a reason deserbing why tha diagnosis da the laida) Prov!de thc reason for Only ane sidt 7s nathoiogy reoort for wnls caam it not consltsnt with the the discrepancy diagtosis sclected.on thc TCGA Casc Quality Conurot Furn. betwecn the pathiology report and the TCGA fo shoWc w:H 5ome Cast Qualfity Control Form. froZzn sec+or art;$<t <a CC:+o ~ a paQlary. Hto weveg. Feyirsred r&y hau 0o+o1o gj5t Idrfio- Sho an. Cjlor cell Co- Provide the name olthe pothologist who revicwed this case Name of Tss Rcviewing for TCGA. Patnologist or 6en<$f of revsri -g. Blorepository Dir ec tor. i ackuowledge that the ahove informatton prorivea ty my In:dadon ts cry ualjty centrnlled. TSS Revi 'athologist or Biorepository Director Date I ocknowiedgs thas the ubrve innrmoton provided by my insdcudon ts true on carrect and hos heen quality controled the Attending Pathviogis or the Department Chairmon has been informed or is aware of trx above disercpancy in dlagaosex. I'rincipal Investigator Signature Date
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diff --git a/output/text/243a8a77-355a-4242-915e-f246c2a17bca.txt b/output/text/243a8a77-355a-4242-915e-f246c2a17bca.txt
new file mode 100644
index 0000000000000000000000000000000000000000..53e3eac42c7f0feacebf380401e2d9290bcdd4bf
--- /dev/null
+++ b/output/text/243a8a77-355a-4242-915e-f246c2a17bca.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+lCs-6-3 Carcnoma hwthlxl,nos8/2o|3 UUID:77EEB28E-813B-41FD-B503-8C107D16FE38 Site: 5/nddr,Nos C47,9 TCGA-G2-A2EC-01A-PR Redacted PATHOLOGY REPORT h 5|3y|H DIAGNOSIS (A) BLADDER TUMOR: UROTHELIAL CARCINQMA WITH NESTED FEATURES, HIGH-GRADE (GRADE 3), EXTENSIVELY INVASIVE INTO MUSCULARIS PROPRIA, SUSPICIOUS FOR LYMPHOVASCULAR INVASION. Ulceration, necrosis, inflammation, and reactive stromal cells, suggestive of prior resection changes. GROSS DESCRIPTION (A) BLADDER TUMOR -- Received is a 4.0 x 3.5 x 2.5 cm aggregate of tan-gray fibrous tissue. The specimen is submitted entirely in A1-A8. CLINICAL HISTORY Bladder cancer.
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diff --git a/output/text/245b91ae-1b80-4778-bce2-0cc812d63411.txt b/output/text/245b91ae-1b80-4778-bce2-0cc812d63411.txt
new file mode 100644
index 0000000000000000000000000000000000000000..db445ffae229fc5e5bdee6a8b3069269861bebf8
--- /dev/null
+++ b/output/text/245b91ae-1b80-4778-bce2-0cc812d63411.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Page 1 of 3 UUID:D7C86FB0-811D-4B63-A8DF-E8A7BFB117C6  TCGA-Ib-AAUr-0iA-Pr Redacted CONFIDENTIAL SURGICAL PATHOLOGY REPORT Time Collected Time Received Tlme Reported Time Transmitted Order Number Ordering Provider  Status Final Relevant Information Location Copied To Report Patient Name:  Demographics (for verification purposes) Sex: M LcD O3 SURGICAL PATHOLOgy REPORT derocsreninge,duc+NOS *****Surgical Pathology Rep. 8 s00/3 Site: Prcreas heael Accession Number Collected Date/Time Received Date/Time 085.0 Pathologist A J5120/14 Specimen Description A: Lymph node no 8 at B: Portal lymph node at C: Galibladder at D: Whipple specimen at. E: Pancreas at Clinical Information Pancreatic mass Infectious patient: No Immunocompromised: No History of neoplasm: No Diagnosis A. Lymph Node, #8, Excision: One lymph node involved by metastatic adenocarcinoma (1/1). B. Lymph Node, Portal, Excision:. One lymph node, negative for malignancy (o/1).. C. Gallbladder, Cholecystectomy:. Chronic cholecystitis with mild activity.. Cholesterolosis. One cystic duct lymph node, negative for malignancy (0/1). D. Head of Pancreas and Duodenum, Whipple Resection: Invasive ductal adenocarcinoma, well differentiated with foamy gland pattern and large duct pattern, 3.7 x 3.5 x 3.5 cm.  Lymphatic invasion, venous invasion, and perineural invasion present. Nine of twenty-one lymph nodes involved by metastatic adenocarcinoma (9/21).  Adenocarcinoma involves common bile duct margin and retroperitoneal margin. Proximal and distal duodenal margins negative for malignancy Please see comment and synoptic report.. E. Pancreas, Neck Margin, Biopsy:. Please see comment. Reported by: Electronically sianed bv: Verified:
+
+--- Page 2 ---
+Page 2 of 3 Synoptic Report SPECIMEN: Head of pancreas PROCEDURE: Pancreaticoduodenectomy (Whipple resection), partial pancreatectomy TUMOR SITE: Pancreatic head TUMOR SIZE: Greatest dimension: 3.7 cm Additional dimensions: 3.5 x 3.5 HISTOLOGIC TYPE: Ductal adenocarcinoma HISTOLOGIC GRADE: G1:  Well differentiated MICROSCOPIC TUMOR EXTENSION: Tumor invades peripancreatic soft tissues. Tumor invades retroperitoneal soft tissue  Tumor invades extrapancreatic common bile duct MARGINS: Margin(s) involved by invasive carcinoma Uncinate process (retroperitoneal) margin (nonperitonealized surface of the uncinate process) Common bile duct margin. TREATMENT EFFEcr (applicable to carcinomas treated with neoadjuvant therapy): No prior treatment LYMPH-VASCULAR INVASION: Present PERINEURAL INVASION: Present PRIMARY TUMOR (pT): pT3: Tumor extends beyond the pancreas but without involvement of the celiac axis or the superior mesenteric artery REGIONAL LYMPH NODBS (pN) : Number examined: 24 Number involved: 10 DISTANT METASTASIS (pM) : Not applicable ADDITIONAL PATHOLOGIC FINDINGS: Chronic pancreatitis CLINICAL HISTORY: Not specified Gross Description Received are specimen containers A to E. 11 isitions and specimen containers are labelled with the patient's name,. The cassettes and identifiers are labelled with the Surgical Number The specimen is received fresh and is subsequently placed into formalin.. The A: container is designated "lymph node no 8" and contains a 2.5 x 1.0 x 0.5 cm firm tan yellow ovoid portion of tissue grossly consistent with a lymph node. On sectioning, the lymph node is firm, white, and grossly suspicious. The trisected lymph node is submitted entirely in Al and A2. B The specimen is received fresh and is subsequently placed into formalin. The container is designated *portal lymph nodes" and contains an irregular heavily cauterized, 0.9 x 0.5 x 0.3 cm greyish tan tissue fragment. The fragment is bisected and submitted in toto in Bl.. C: The specimen is received fresh and is subsequently placed into formalin. The container is designated "gallbladder" and contains an intact unopened 6.5 x 3.5 x 2.0 cm gallbladder. The gallbladder serosa is smooth and shiny without nodules or adhesions,. and the adventitial surface is slightly roughened. The cystic duct is open. The cystic duct margin is inked black. A 0.8 x 0.6 x 0.5 cm plump ovoid cystic duct lymph node is. present.  The gallbladder lumen contains viscous green bile and no gallstones. The gallbladder wall is thin, pliable, and approximately 2 mm thick..  The galibladder mucosa is green and velvety with marked yellow speckling suggestive of cholesterolosis. There are no polyps, masses or other lesions.  Representative sections are submitted as follows: C1. bisected cystic duct lymph node and black - inked cystic duct margin C2. two representative sections of gallbladder mucosa, one from near gallbladder neck and one from fundus D: The specimen is received fresh and is subsequently placed into formalin. The container is designated "Whipple's specimen" and contains a 23 cm long portion of duodenum with attached 6.5 x 5.5 x 3.5 cm portion of the pancreatic head.. The duodenum
+
+--- Page 3 ---
+Page 3 of 3 has an average linear circumference of 4 cm, and the distal 13 cm of the duodenum shows dusky ischemic discoloration. The duodenal mucosa has the normal pattern of folds, without polyps or other lesions.  The retroperitoneal margin (designated with a blue suture) is inked blue and the sMA groove is inked green, and the pancreatic neck margin is inked black. A portion of the pancreatic duct is identified at the pancreatic neck margin, but the duct appears occluded less than 1 cm from the margin. Replacing much of the head of the pancreas, there is an ill-defined roughly 3.7 x 3.5 x 3.5 cm firm rubbery tan white mass with infiltrative borders.  On sectioning, the central portion of the mass contains numerous cystic spaces filled with thin clear mucin. Grossly, the mass abuts the retroperitoneal margin and the smA groove but does not clearly involve those margins. The mass closely abuts the common bile duct, which contains a metal stent.  The mass also. Numerous lymph nodes are identified in the surrounding peripancreatic fat, a few of which are slightly enlarged and firm. Representative sections are submitted as follows: D1. proximal duodenal margin D2. distal duodenal margin D3. bile duct margin D4. tumor with pancreatic neck margin D5-7. three contiguous sections of tumor showing relationship of tumor with common bile duct and retroperitoneal margin D8. one lymph node bisected (represents the remainder of the lymph node previously sampled in b5), one additional possible lymph node inked blue and submitted whole D9. tumor with pancreatic margin D10. tumor with common bile duct and SMA groove D11. one peripancreatic lymph node trisected D12. section of tumor with bile duct D13. peripancreatic fat with possible lymph nodes D14. two lymph nodes (one node inked blue and bisected) D15. one node bisected D16. two lymph nodes (one node inked blue and trisected) D17. additional section of tumor with bile duct and ampulla D18-19. central portion of tumor with cystically dilated spaces filled with mucin D20. one lymph node trisected D21. two lymph nodes (one node bisected, one node inked blue submitted whole) D22-25. additional peripancreatic fat with possible lymph nodes E: The specimen consists of pink tan tissue measuring 2.2 x 1 x 0.3 cm.  Submitted in toto in E1. The specimen is received fresh for intraoperative consultation in a container designated "pancreas neck". The previously frozen tissue is entirely resubmitted for permanent sections in EQsl. Frozen Section Diagnosis E: Pancreatic Neck: Chronic inflammation with some dilated ducts. No malignancy in the sampled sections. Reported by: Pathologist Comment E. Permanent sections of the pancreatic neck margin (i.e. slide E1-2) reveal rare crushed atypical cells, present in pools of mucin surrounding a nerve, highly suspicious for adenocarcinoma. These cells are not definitively identified in the original frozen section slides. Since the frozen section represents the "true" margin, and the permanent sections are cut from deeper (more distal) tissue, it is estimated that the true pancreatic neck margin is negative but that tumor extends very close (likely 1-2 mm) to this margin. In case ancillary studies are desired, tumor block information is listed below: Best tumor block: D9 Best normal block: C2 Accession Number Encounter Number. Patient Locatlon Criteria Diagnosis Di HIPAA Discrepancy is circle DISQUALIFIED
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diff --git a/output/text/248664a4-a64e-4e11-b250-12a087c6de51.txt b/output/text/248664a4-a64e-4e11-b250-12a087c6de51.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b76926ac68e8091fee7aa1b751db28b1e6d66dda
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:6F1D0DF7-40E0-453A-B5A1-240C90EED5C1 tcgA-pj-a8Ju-01a-pr Redacted Patient: Pathology #: Med. Record. No.: Date of Procedure: Date of Birth: Sex: Date Received: Submitted by: Report also to: Pathology Report TcD-0-3 Cersnons, yoapillery rira DIAGNOSIS: 8Q60|3 ee0l Site: RYidrey Nos C649 SPECIMEN Right radical nephrectomy TUMOR Histologic type: Papillary renal cell carcinoma Histologic grade (Fuhrman nuclear grade): Grade 2 Focality: Solitary within specimen Tumor size (greatest dimension):3.5cm Extent of direct tumor invasion:.  No direct extension beyond kidney. Sarcomatoid component: Absent Lymphovascular invasion (excluding renal vein):  Absent Renal vein involvement:  Absent Pathologic findings in non-neoplastic kidney:. No additional significant pathologic findings. Adrenal:  Not present MARGINS All margins negative for carcinoma. LYMPH NODES Cannot be assessed STAGING (AJCC) Primary Tumor: pT1a Lymph Nodes: pNX Distant Metastasis: Not applicable CLINICAL INFORMATION: Right renal mass. SPECIMEN(S) RECEIVED: Right kidney Pathology Report Page 1 of 2
+
+--- Page 2 ---
+Patient: MRN: GROSS DESCRIPTION: Received fresh is a 643 gram radial nephrectomy which consists of a 9 x 6.5 x 5.5 cm kidney and surrounding perinephric fat, 0.8 to 6 cm. An adrenal gland is not submitted with the specimen. Located centrally in the mid pole of the kidney is a soft, nodular, well-circumscribed 3.5 x 3 x 2.5 cm dark red to red-yellow mass. The lesion compresses the renal pelvis but does not grossly appear to invade into it. The lesion grossly comes to within 0.1 cm of the cortical surface and to within 0.6 cm of Gerota's fascia which is inked. Sectioning through the rest of the kidney reveals glistening, unremarkable maroon-gray parenchyma with cortical thickness measuring 0.6 to 1.1 cm.. Dissection of the ureter and vessels at the renal hilum reveals patent lumina with no gross evidence of tumor invasion. Representative sections are submitted as follows: A1 -- ureter and blood vessels margins; A2 -- A4 --- mass with adjacent normal kidney and renal pelvis; A5 -- mass with inked Gerota's fascia; A6 -- normal kidney. Slldes were microscopically examined by the pathologist. Eyaluationperforned Pathology Report
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diff --git a/output/text/24878cbc-bb7c-4e05-9e44-24b013b12210.txt b/output/text/24878cbc-bb7c-4e05-9e44-24b013b12210.txt
new file mode 100644
index 0000000000000000000000000000000000000000..969e44cc9a8c62fc2da55d1493c2a37a92ca188a
--- /dev/null
+++ b/output/text/24878cbc-bb7c-4e05-9e44-24b013b12210.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+path report Microscopic Sections demonstrate a glioma with biphenotypical features including both astrocytic and oligodendroglial components. The oligodendroglial component. demonstrates individual tumor cells with round nuclei and prominent perinuclear halo formation. They are embedded in a fibrillary background containing thin. branching vessels and microcystic change. Numerous microgemistocytes are. interspersed throughout the tumor. The astrocytic component consists of neoplastic glial cells with oval nuclei and prominent fibrillary processes. The tumor cells diffusely infiltrate the adjacent brain parenchyma. Overall, the cytologic atypia is mild to moderate. Neither necrosis nor microvascular proliferation is seen. Only a rare mitotic figure is identified. These histologic features are consistent with an oligoastrocytoma Addendum A MIB-1 labeling index ranges up to 2.4% consistent with a low grade glioma. Diagnosis Oligoastrocytoma, low grade II.
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diff --git a/output/text/248b97b1-3beb-48e1-8784-ea9c909b35f2.txt b/output/text/248b97b1-3beb-48e1-8784-ea9c909b35f2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e13818d0dba512b5494c8d99acfd6be04e6fcdad
--- /dev/null
+++ b/output/text/248b97b1-3beb-48e1-8784-ea9c909b35f2.txt
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+
+--- Page 1 ---
+Clinical Diagnosis & History:. Patient with right renal mass.. Specimens Submitted:. 1: Kidney, right, perinephric "fat", partial nephrectomy DIAGNOSIS: 1. Kidney, right, perinephric "fat", partial nephrectomy Tumor Type: Renal cell carcinoma - Conventional (clear cell) type Fuhrman Nuclear Grade: Nuclear grade II/IV Tumor Size: Greatest diameter is 2.5 cm.. Local Invasion (for renal cortical types):. Not Identified Renal Vein Invasion:. NA Surgical Margins:. Free of tumor Non-Neoplastic Kidney: Focal myoid metaplasia Adrenal Gland: Not identified Lymph Nodes: Not identified Staging for renal cell carcinoma/oncocytoma: pT1 Tumor < 7.0 cm in greatest dimension limited to the kidney Comment: Unremarkable perinephric adipose tissue  Page 1 of 2
+
+--- Page 2 ---
+Gross Description:. 1). The specimen is received initially fresh, and later in formalin, after having been inked black and breadloafed for retrieval of. tissue for TPS, labeled, "Right partial nephrectomy and perinephric fat", and consists of a portion of red-tan kidney parenchyma measuring 4.5 x 3.5 x 2.3 cm upon reconstruction of the specimen. It shows a 2.5 x 2.5 x 2.2 centimeter well circumscribed somewhat lobulated yellow-tan tumor. It is located 0.1 cm from the black inked margin. The remainder of the parenchyma is. red-tan and grossly unremarkable. What appears to be the capsule of the kidney is inked blue. The tumor grossly abuts this blue inked surface. Also received in the container is an unoriented piece of yellow-tan fatty tissue measuring 6 x 5 x 1.2 cm. cut sections the tissue is grossly unremarkable. Representative sections are submitted.. Summary of sections: T-representative sections of tumor with black inked margin and capsule. RS-representative section of uninvolved kidney parenchyma. FAT -- fat Summary of Sections: Part 1:Kidney, right, perinephric "fat'", partial nephrectomy. Block Sect. Site PCs 1 fat 1 1 rs 1 4 t Page 2 of 2e END OF REPORT
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diff --git a/output/text/248d0772-1758-4a30-94fe-ae2d843b6f5c.txt b/output/text/248d0772-1758-4a30-94fe-ae2d843b6f5c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..af867e7487fa3cd936f05c58a472aa23e649c688
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+
+--- Page 1 ---
+Surgical Pathology Report Name: Case #: DOb: Collected: Gender: Received: MrN: Reported: Location: Copy To: Physician: Pathologic Interpretation: A. Right breast short stich superior long lateral right singie mastectomy:. - Benign mammary parenchyma, no malignancy seen. B. Left breast and level I and ll of axilla to tumor short superior, left lateral:. - Invasive ductal carcinoma, Nottingham grade 3 (3+3+2), 2.8 cm in greatest linear dimension, focally presert at the anterior specimen margin.. - Ductal carcinoma in situ, high grade (DIN 3) solid type - Organizing previous biopsy cavity. - Lymphovascular space invasion is present. - Metastatic carcinoma in four out of nine lymph nodes (4/9).. 1cs-0-3 - Receptors to foitow. Caciomu mfilfrutnz ouctl! Nos 8500/3 c. Additional fat above left breast tumor: Sin: braot. Nos Cse.9 /8/11 - No malignancy seen in adipose tissue. hs D. Left leve! IIl axilla:. - No malignancy seen in four lymph nodes (0/4). UUID:F5EF4698-364C-4A58-A8EC-1CF231BEEF31 TCGA-EW-A1IZ-01A-PR Redacted Tumor Summary (Invasive Carcinoma of the Broast): Specimen Type: Total breast (including nipple and skin) Procedure: Total mastectomy (including nipple and skin) Lymph Node Sampling: Axillary dissection (partial or compiete dissection) Specimen Integrity: Single intact specimen (margins can be evaluated) Specimen Laterality: Left Tumor Site: Lower outer quadrant; Lower inner quadrant Tumor Size: Size of Largest Invasive Carcinoma: Greatest dimension of largest focus of invasion: 2.8 cm Tumor Focality: Single focus of invasive carcinoma Macroscopic and Microscopic Extent of Tumor: Skin: Invasive carcinoma does not invade into the dermis or epidermis. Nipple: DCIS does not involve the nipple epidermis Skeletal Muscle: No skeletal muscle present Ductal Carcinoma In Situ: DCIS is present Architectural Patterns: Solid Nuclear Grade: Grade ill (high) Lobular Carcinoma in Situ: Not identified Histologic Type of Invasive Carcinoma: Invasive ductal carcinoma (no special type or not otherwise specified) Histologic Grade:. Glandular (Acinar)/Tubular Differentiation: Score 3 Nuclear Pleomorphism: Score 3 Mitotic Count: Score 2 Overall Grade: Grade 3 Margins: Uninvolved by invasive carcinoma Distance from posterior margin: 2 cm Uninvolved by DCIS (if present) Lymph-Vascular Invasion: Present Dermal Lymph-Vascular Invasion: Not identified Lymph Nodes: Number of sentinel lymph nodes examined: 0 Total number of lymph nodes examined (sentinel and nonsentinel): 13. Number of lymph nodes with macrometastases: 4 Size of largest metastatic deposit: 2.0 cm. Extranodal Extension: Not identified
+
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+SURGICAL PATHOL Report  Method of Evaluation of Sentine! Lymph Nodes: Hematoxylin and eosin (H&E). one level Pathologic Staging (pTNM) TNM Descrlptors: m (multiple foci of invasive carcinoma) Primary Tumor pT2 Regional Lymph Nodes: pN2 Distant Metastasis: Not applicable Ancillary Studies: Estrogen Receptor: Pending Progesterone Receptor: Pending Her2: Pending ***Electronically Signed Out By*** NOTE: Some inmunohistochemical antibodies are analyte spocfic reagents (ASRs) validated by our laboratory (Her 2, Parvo, H. pytori. HBcore). Theis ASRs are cinicaly u ors tha not req ure FDA approval These con*s are us6d: iD5=ER. PgR 636=PR,A485*HER2, H-11=EGFR, CCH2/DDG9=CMV, F39.4.1=AR and HPV by ISH. A# immunohistocl with formalin or molecular fixed, paraffin embedded tissue. Detection is by LSA8. The resuits are read by a pathologist as positive or negative As the attending pathologist, / attes that I: (i) Examinedthe reievent preparetion(s) For the specimen(s); and (hi) Rendored thh diegnosie(ea). Procedures/Addenda Addendum Date Ordered: Status: Signed Out Date Complete: Date Reported: Addendum Diagnosis The tumor cells are positive for ER and PR and negative for HER2 by immunohistochemistry. Immunohistochemistry fpr p63 was used in the evaluation of the specimen. Clinical History: female with left breast cancer Pre Operativo Diagnosis: Left breast cancer Specimen(s) Received: A: Right breast short stich superior long lateral right single mastectomy (fresh) B: Left breast and tevel I and Il of axilla to tumor short superior, left lateral (fresh) C: Additional fat above left breast tumor (perm) D: Left ievel I!l axilla (perm). Gross Description: A. Received fresh and labeled "right breast short stich superior long lateral right single mastectomy (fresh)" is a treast specimen measuring 18.0 x 15.0 x 5.0 cm. It has a white-tan ellipse of skin measuring 4.0 x 1.0 cm. The nipple measures 1.0 x 1.0 cm. The skin is unremarkable and nipple is unremarkable. Deep margin is smooth, facial plane without any Page 2 of 3
+
+--- Page 3 ---
+SURGICAL PATHOL Report skeletal muscle. Deep margin is inked in black. Serial sectioning of the mastectomy specimen does not reveal any gross Iesion. Specimen submitted as follows: 1&2 Sections from upper outer quadrant 3&4 Representative section from lower outer quadrant 5&6  Representative section from upper inner quadrant 7&8  Representative section from lower inner quadrant 9&10 Representative section from central quadrant 11  Representative section from nipple B. Received fresh and labeled *left breast and level I and ll of axilla to tumor short superior, left lateral (fresh)" i$ a mastectomy specimen measuring 19.0 x 17.0 x 3.0 cm. It has a white-tan ellipse of skin measuring 2.5 x 2.0 km. The axillary tail measures 13.0 x 9.0 cm. The skin and nipple are unremarkable. Deep margin is smooth, facial plane without. any skeleta! muscle. Deep margin is inked black, superior margin is inked blue, medial margin is inked red and inferior  margin is inked green. Serial sectioning of the mastectomy specimen reveals a 2.8 x 2.0 x 1.5 cm firm gray mass located  in the lower outer quadrant, less than O.1 cm from the inked anterior s specimen margin. There is also a 1 x 1  1 cm mass in the lower inner quadrant. The mass is well defined. It has a clip in it. in the upper inner quadrant, there is an area of  necrosis measuring 2.0 x 2.0 x 1.0 cm. It is brown in color and soft in consistency. Remainder of the breast parenchyma is predominantly white and firm with small cyst measuring up to 0.3 cm in greatest dimension. The axillary tail i$ yellow and soft. There are 13 possible lymph nodes. The largest measures 3.0 cm in greatest dimension. Sections submitted as. follows: 1-8 Mass in the lower inner quadrant 9&10 Area of necrosis 11&12  Representative section from upper outer quadrant 13&14  Representative section from lower outer quadrant 15&16 Representative section from upper inner quadrant 17&18 Representative section from lower inner quadrant 19&20 Representative section from the central quadrant 21 Representative section from the nipple 22-24 Contains representative section from the largest lymph node 25-37 One tymph node per cassette 38-41 Additional section of mass in iower outer quadrant c. Received in formalin and labeled *additional fat above left breast tumor' is a sott fragment measuring 2.5 x 1.0 x 1.0 cm. Submitted in toto in three cassettes. D. Received in formalin and labeled *left level ill axilla" is a pale yellow, soft tissue fragment measuring 4.0 x 3.dx 2.0 cm. Four possible lymph nodes are bisected and submitted in toto in four cassettes. ICD-9(s): 174.5 174.3 198.3  Page 3 of 3
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diff --git a/output/text/249a7c23-9aa1-4eea-863b-9c17ab270897.txt b/output/text/249a7c23-9aa1-4eea-863b-9c17ab270897.txt
new file mode 100644
index 0000000000000000000000000000000000000000..165211b72647248959fa39dc5714e3ed691fc606
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+--- Page 1 ---
+TCGA-A6-2674 SPECIMEN A. Sigmoid colon. B. Right abdominal wall tumor. C. Omentum CLINICAL NOTES PRE-OP DIAGNOSIS: Left colon cancer. GROSS DESCRIPTION A. Received fresh, labeled "sigmoid colon", is a previously unopened, 31 cm. segment of distal colon, surfaced by smooth and glistening tan-pink serosa, with a copious amount of attached mesocolon. The undesignated margins measure 3.8 and 10.2 cm. in circumference.. On opening, there is a. circumferential, well-circumscribed, 5 x 4.5 cm., partially necrotic tan-white tumor mass, located 10 cm. form the smaller circumference margin. A portion of the tumor and a portion of normal mucosa are submitted for tissue procurement, as requested. On sectioning, the tumor has a maximal thickness of 2 cm., grossly extending through the muscularis to within 0.8 cm. of the inked free radial serosal surface.  The remaining mucosa is unremarkable, glistening tan-pink, with regular folds, and the wall averages 0.5 cm. in thickness. Multiple, slightly rubbery tan-white to tan-pink tissues, in keeping with lymph nodes, measuring up to 4.8 cm. in greatest dimension, are recovered from the attached mesocolon. Representative sections are submitted in fourteen blocks, as labeled. Rs-14 BLOck sumMARy: 1 - Undesignated margins (smaller circumference margin inked blue); 2,3 - tumor full thickness to inked free radial serosal surface; 4 - central tumor; 5 - tumor to normal mucosa; 6 - random normal mucosa; 7 - eight whole lymph nodes; 8,9 - six whole lymph nodes per cassette; 10-12 - one representative section from each of three grossly positive nodes (one node represented per cassette); 13,14 - two representative sections from largest, grossly GROSS DESCRIPTION positive lymph node. B.  Received in formalin labeled "right abdominal wall tumor is a 1.5 x 0.7 x 0.5 cm yellow lobular fatty tissue. fragment which shows a 0.2 cm white-tan rubbery nodule on the surface.  The specimen is bisected and entirely submitted in one cassette. AS-1. C. Received in formalin, labeled "omentum" are multiple pieces of fat described below. The specimen is sectioned to show a yellow lobular fatty cut surface grossly consistent with
+
+--- Page 2 ---
+omentum. The specimen shows a 1.5 x 0.7 x 0.1 cm. focus of white-tan. rubbery tissue which may be grossly consistent with fibrinous exudate or possible adhesion tissue. The specimen is also further palpated to identify a 2.2 cm. white-pink-tan rubbery nodule. No. other discrete gross lesions are identified. Representative sections. of the specimen are submitted in eight cassettes. Rs-8 MICROSCOPIC DESCRIPTION A-c. Microscopic examination reveals: Histologic type:. Invasive adenocarcinoma, Mucinous. Histologic grade: Poorly differentiated.. Primary tumor (pT): Tumor invades through the muscularis propria into the pericolonic fat (pT3). Proximal margin: Negative for tumor.. Distal margin:. Negative for tumor.. Circumferential (radial) margin: Negative for tumor. Distance of tumor from closest margin: 10 cm. from one of the undesignated mucosal resection margins Vascular invasion:. Lymphatic space invasion present. (Slide A5). Regional lymph nodes (pN): Metastatic adenocarcinoma is present in 7 of 20 lymph nodes (pN2). The largest metastasis measures 4.8 cm. MICROSCOPIC DESCRIPTION Non-lymph node pericolonic tumor: Present. Distant metastasis (pM): Metastatic tumor is present in the B specimen in the right abdominal wall with an 0.2 cm. nodule within. that. Metastatic tumor is also present in the omentum with a 2.2 cm. nodule within the fat. (pml). Other findings: Diverticulosis. 5x1, 3x2, 3260F. DIAGNOSIS A. Colon, sigmoid, segmental resection:. Invasive mucinous adenocarcinoma, poorly differentiated. Invasive in to pericolonic fat (pT3). Metastatic adenocarcinoma present in 7 of 20 pericolonic lymph nodes (pN2). Extranodal tumor present. The resection margins are negative. Diverticulosis also present.. B. Right abdominal wall tumor, biopsy: Metastatic mucinous adenocarcinoma. C. Omentum,  biopsy: Metastatic mucinous adenocarcinoma.
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diff --git a/output/text/24c6a11f-ee12-4ebc-a64d-68e3ce2a38bb.txt b/output/text/24c6a11f-ee12-4ebc-a64d-68e3ce2a38bb.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c29e7f7a6023ad10b5d775e0548c92c1f588b339
--- /dev/null
+++ b/output/text/24c6a11f-ee12-4ebc-a64d-68e3ce2a38bb.txt
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+
+--- Page 1 ---
+IcD-o-3 UUID:4BCA8C55-997E-4700-A12C-B520575C3608 TCGA-MY-A5BD-01A-PR Redacted 8070|3 Site: Cervix ltererCerviya Patient Name C 53.9 A/13 Requested B) Ordered By Surg Path Case - STATus: Final **SEE NOTE Collect/Perform: Ordered Date: Department: PATH Physician Who Performed Procedur Requesting Physicia! Attending Pathologist DIAGNOSIS: 1. Lymph nodes, right common iliac, biopsy: - Three lymph nodes; no tumor seen (0/3). 2. Lymph nodes, right obturator, biopsy: - Two lymph nodes; no tumor seen (0/2). 3. Lynph node, left external iliac, biopsy:. One lymph node; no tumor seen (0/1). 4. Lymph nodes, right obturator, biopsy:. - Six lymph nodes; no tumor geen (0/6) 5. Lymph nodes, left external iliac, biopsy: Fourteen lymph nodes: no tunor seen (o/14). 6. Uterus, cervix, and bilateral adnexa, radical hysterectomy and. salpingo oophorectomy: Invasive squamous cell carcinoma of cervix, 7.8 cm, well to moderately differentiated, extending to endometrial cavity, and invading through the cervical wall superficially into the parametrim (see FUll. REporr below) . Cervical intraepithelial neoplasia Ill/carcinoma in situ arising in a background of squamous metaplasia of adjacent endocervical mucosa.. - Foci ot lymphovascular invasion seen.
+
+--- Page 2 ---
+Patient Requested By Ordered By e carcinoma is minimally transected at the inked and cauterized parametrial margin (slide 6H) The resection margins of vaginal cuff are negative for carcinoma. NO M-n/a (FIGO IIB) - AJcc Pathologic Staging: pT2b FULL Reporr (incorporates relevant findings from all parts): - Histologic Type of Tumor: Squamous cell carcinona - Histologic Grade of Tumor: G1 - G2; well to moderately Tumor Site: Four guadrants with the right superior quadrant being dominant (9:00 - 12:00). Tumor Size: Createst dimension: 7.8 cm; other two dimensions: 4.1 x 2.0 cm Other Organs Present: Uterine corpus, bilateral ovaries and fallopian tubes. Extent of Invasion: Invades through the cervical. wall into parametrium (slides 6k, 6Ak), and extends to lower uterine segment. - Margins: Positive for invasive carcinoma Positive margin, or margin closest to invasive carcinoma: Parametrial margin near 6:00 (slide 6H) Distance of invasive carcinoma to closest margin: 0 mm. Carcinoma In-Situ: Present Venous/Lymphatic (Large/Smail Vessel) Invasion: Present. Distant Metastasis: Cannot be assessed - Regional lymph nodes t# positive/# examined): 0/26  Additional Pathologic Findings: Atrophic endometrium; bilateral fallopian tubes and ovaries without significant histopathologic findings. - AJcc Pathologic Staging: pT2b NO M-n/a (F1CO I1B) COMMENT: None CI.INICAL INFORMATION: Preop diagnosis of cervical cancer GROSS DESCRIPTION: 1. The specinen is received fresh tor frozen section and labeled "right common iliac lymph node". The specimen consists of a yellow tan, lobulated portion cf adipose tissue measuring 4.5 x 2.0 x 1.0 cm. The specimen is palpated to reveal two lyrph ncdes measuring 0.7 and 2.3 cm in greatest dimension. The specimen is subritted entirely in tour cassettes as follows. 2 oF 5
+
+--- Page 3 ---
+Patient Name Requested By Ordered By:. larger lymph node. C:  smaller lymph node D: adipose tissue Intraoperative report: Two lymph nodes; no tumor seen. 2. The specimen is received fresh for frozen sect.on and labeled *right obturator lymph node". The specimen consists of a lymph node measuring 2.4. x 1.4 x 1.2 cm. The specimen is submstted entirely in three cassettes. follows:  one matted lyrph node C: adipose tissue 3. The specimen is received fresh for frozen section and labeled left external iliac pelvic Iymph node". The specimen consists of one ovoid,. hemorrhagic lymph node measuring 3.5 x 2.0 x 1.2 cm. The specimen is bisected ard submitted entirely in two cassettes labeled Intraoperative report: One lymph node. No tumor seen.. 4. The specimen is received fresh and labeled "riyht obcurator lymph node". The specimen. consists of multiple. yellow-tan, lobulated portions of adipose tissue measuring 8.2 x 5.0 x 1.a cm in aggregate. The specimen is. palpated to reveal six possible lymph nodes ranging from 0.8 to 3.0 cm in greatest dimension. The specimen is submitted entirely in nine cassettes as. follows: 4A: Two possible Iymph nodes 4B: two possible lymph nodes 4C-4D: one lymph node bisected 4E-4F:  one lymph node bisected 4G-4I:  adipose tissue . The specimen is received fresh and labeicd "left external iliac lymph node". The specimen consists of multiple, pink-tan. lobulated portions of adipose tissue measuriny 9.0 x 5.0 x 1.8 cn in aggregate. The specimen is palpated to reveal 10 possible lymph nodes ranging from 3.5 to 3.1 cm in. greatest dimension. The specimen is submitted entirely in ll cassettes as tollows: 5A: Four possible lyinph nodes 5B: two possible lymph nodes. 5c: ore lymph node bisected 5D:  ore lymph node bisected 3 op 5
+
+--- Page 4 ---
+Patient Na Requested By: Ordered By:k 5E-5f:  one lymph node bisected 5G-5H: one lymph node bisected 5I-5K: adipose tissue 6. The specimen is received fresh and labeled #uterus tubes/ovaries/parametrium/vagina inked margins and send for tumor studies". The specimen consists of a total hysterectomy specimen measuring 10.0 cm from fundus to cervical mucosa, 4.3 cn from cornu to cornu and 3.0 cm Erom anterior to posterior. The attached cervix measures 4.5 x 4.0 x 4.0 cm with a rim of vaginal cuff. The os is slit-like and measures o.8 cm. Located at. the three o'clock to nine o'clcck aspect ig a pink-tan, bosselated, protruding mass measuring 2.0 x 1.5 cm. The anterior is inked green and the posterior is inked black. A 0.6 cm portion of taken for research from the. nine o'clock aspect. extends the entire length of the cervix and into the uterus for an overall measures 6.0 x 2.0 cm and the distal portion is distorted by the mass. The specimen is serially sectioned to reveal the mass grossly extends to the posterior margin (from approximately 6 o'clock to the 10 o'clock) and 0.1 cm from the anterior margin. The attached right adnexa is composcd of a fimbriatcd fallopian tube measuring 1.0 x 0.6 x 0.5 cin ard an attached, cerebriform ovary measuring 2.7 x 1.4 x 1.0 cm. The fallopian tube is serially sectioned to rcveal a pinpoint lumen. The ovary is serially sectioned to reveal normal ovarian parenchyma with a corpus albicans. The attached left adnexa are composed of a fimbriated fallopian tube. measuring 7.5 x 0.5 x 0.5 cm ard a tan-pink, cerebriform ovary measuring 2.7 x 1.5 x 1.0 cm. Tne tallopian tube 1s serially sectioned to reveal a. pinpoint lumen. The ovary is serially sectioned to reveal normal ovarian parenchyma with a corpus albicans. Representative sections are submitted in 4l cassettes as follows /cervix and vaginal cuff submitted entirely): 6A-6C: cervix with attached vaginal cutf, 12 o'clock tc three o'clock 6D-6G: cervix with attacred vaginal cuff. chree o'c!ock to s1x o'clock 61-6M: cervix with attached vaginal cuif, six o'clock to nine o'clock 6N-6S: cervix with attacred vaginal cuff, nine o'clock to 12 o'clock (6N-6O: one slice) 6T left adnexa 60-6X: left parametrium 6Y: right adnexa 4 oF5
+
+--- Page 5 ---
+Patient Nam. Requested By. Ordered By:. 6Z-6AE: right parametrium 6AF-6AG: anterior lower uterine segment (representative sections). 6AH-6AI:  anterior endomyometrium 6AJ-AM: posterior lower uterine seyment (representative 6AN- 6AO :  posterior endomyometrium * klectronic Signature ** **Electronically Signed Out by I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the tinal diagnosis(es).. The Attending Pathologist. revicwed this case and made the diagnosis.. Where applicable. immunohistochemistry and in situ hybridization tests were. developed and the performance characteristics determined by the. Immunohistochemistry Laboratory. These tests.  have not been cleared or approved by the Us Food and Drug Administration and the results should be correlated with other clinical and laboratory. data. Appropriate controls were pertormed tor ali immunohistochemistry, in situ hybridization and histochemical tests. se1s (circic RevirwedA) 6 0F T
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diff --git a/output/text/24d3718d-d254-488e-8017-c840adb5d15e.txt b/output/text/24d3718d-d254-488e-8017-c840adb5d15e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..df8a29316c3506c9d6bc7a25b6841dd31ccd238f
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+
+--- Page 1 ---
+UUID:64700E97-F031-49DE-83F0-8CCDBDEE23AF TCGA-DD-AAE9-01A-PR Redacted CLINICAL DIAGNOSIS: Hepatocellular carcinoma suggested Specimen : Liver and Liver mass Gross Photo : GROSS: Specimen status: Fresh Operation: Partial hepatectomy Organs: Liver (19.0 x 12.5 x 4.3 cm, 374.0 gm) Lesion: A well-defined round firm mass (5.0 x 4.8 x 4.0 cm) Cut surface: Yellowish tan and granular appearance Gross type: HCC: Expanding nodular Resection margin: Not involved grossly (safety margin: 1.0 cm) Others: ID0-3 Satellite nodule: No Representitive sections were submitted. arenom dupateclluIer NoS Gross photo: Present 817o/3 Sute: sier C23.0 Blocks T1-4, TB, tumor mass x 5 NB, L, liver parenchyma x 2 OtI 5lQo|i<f MICROSCOPIC: Hepatocellular carcinoma: Yes The worst differentiation III The major differentiation II Histologic type: Trabecular Cell type: Hepatic Fatty change: No Fibrous capsule formation: Complete capsule Capsular infiltration: No Septum formation: No Surgical resection margin invasion: No, safety margin (1.0 cm) Serosal invasion: No Portal vein invasion: No Microvessel invasion: No Intrahepatic metastasis: Unknown Multicentric occurrence: Unknown NOT reported. Gross: liver,ectomy,hepatocellular carcinoma,Steatohepatitis,mild steatosis,periportal fibrosis T56000, P10, M81703, Steatohepatitis, mild steatosis, periportal fibrosis DIAGNOSIS: Liver, partial hepatectomy: Hepatocellular carcinoma, moderately differentiated
+
+--- Page 2 ---
+Steatohepatitis with mild steatosis and periportal fibrosis (stage 2) Suggestion : 113
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diff --git a/output/text/24eff359-1fb3-41ba-97ac-d7f08a4b0ece.txt b/output/text/24eff359-1fb3-41ba-97ac-d7f08a4b0ece.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6326dd8274679ebc799383dd6d1b9004aa46170d
--- /dev/null
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+
+--- Page 1 ---
+teD-o-3 UUID:D5277DE4-EC4C-4DF5-9115-CDCE00855758 Pathology Repc. TCGA-CN-A640-01A-PR Redacted Report Type cQQ NoS'C%ozo|3 Date of Event. Sex Sit : Jongue NoS Qoz.9 Authored by Hosp/Group Record Status AJ slo/13 FINAL FINAL DIAGNOSIS: PART 1: TONGUE, RIGHT, HEMIGLOSSECTOMY A. INVASIVE SQUAMOUS CELL CARCINOMA MODERATELY DIFFERENTIATED WITH HIGHLY INFILTRATIVE BORDER (3.5 CM), INVOLVING SKELETAL MUSCLE. B. PERINEURAL INVASION PRESENT. C. MARGINS FREE OF TUMOR (see also Part 2). D. PATHOLOGIC STAGE: pT2N2b. PART 2:  FLOOR OF MOUTH, RIGHT, EXCISION NO TUMOR PRESENT. PART 3:  LYMPH NODES, LEVEL 1A, SELECTIVE DISSECTION FOUR LYMPH NODES, NO TUMOR PRESENT (O/4). PART 4:  LYMPH NODES, RIGHT NECK LEVEL IB, SELECTIVE DISSECTION A. THREE LYMPH NODES, NO TUMOR PRESENT (O/3). B. MILD CHRONIC SIALADENITIS. PART 5: LYMPH NODES, RIGHT NECK LEVELS 2 THROUGH 5, SELECTIVE DISSECTION A. METASTATIC SQUAMOUS CELL CARCINOMA IN TWO OF THIRTY LYMPH nODES (2/30). B. POSITIVE LYMPH NODES IN LEVEL 2 AND 3 (LARGEST: 2.7 CM). C. EXTENSIVE EXTRANODAL EXTENSION WITH INVOLVEMENT OF INTERNAL JUGULAR VEIN ADVENTITIA, AND SKELETAL MUSCLE. D. NECK DISSECTION MARGINS FREE OF TUMOR. PART 6: LYMPH NODES, LEFT NECK LEVEL 1B, SELECTIVE DISSECTION A. TWO LYMPH NODES, NO TUMOR PRESENT (O/2). B. MILD CHRONIC SIALADENITIS. PART 7: LYMPH NODE, LEFT NECK LEVEL 2 THROUGH 4, SELECTIVE DISSECTION TWENTY-FOUR LYMPH NODES, NO TUMOR PRESENT (O/24). Pathologist: ** Report Electronically Signed Out ** By Pathologist: My signature is attestation that I have personally reviewed the submitted material(s) and the final diagnosis reflects that evaluation. GROSS DESCRIPTION: Part 1 is received fresh for intraoperative consultation labeled with patient' S name, initials xx, and "right glossectomy". The specimen consists of hemiglossectomy that measures 6.5 cm from anterior to posterior, 3.5 cm from
+
+--- Page 2 ---
+midline to lateral, and 3 cm from superior to inferior. There is an ulcerated lesion on the lateral side of the tongue with the ulceration measuring 3 x 1.5 cm. The inferior mucosal margin was taken for intraoperative. consultation. The specimen was inked and serially sectioned revealing a firm white tumor measuring 3.5 x 2.4 x 2.2 cm. The tumor comes to within 0.8 cm from the midline, 1.2 from the anterior tip mucosa, 2.3 from the posterior, 0.6 from the inferior mucosal margin, and 0.3 cm from the deep margin. The tumor focally abuts the deep edge (see part two which is additional tissue taken around this area). Gross photographs are taken. Representative. sections are submitted as follows: lAFs- frozen inferior mucosal margin resubmitted. 1B- anterior tip margin 1C- posterior shave margin. 1D- tumor and midline margin, perpendicular cut 1E-F- remainder of midline margin shave. 1G- Tumor and area where it abuts deep edge 1H- Tumor and deep margin. 1I-J- tumor INK CODE: Blue- anterior Green- posterior Black- medial Red- area banked Yellow- inferior mucosal edge. Orange- deep Time in formalin: 32 hours. Part 2 is received fresh labeled with patient' s name, initials xx, and. "right floor of mouth". The specimen consists of salivary gland and attached soft tissue that measure 3 x 1.0 x 0.7 cm. The specimen was oriented by the. surgeon who communicated that this was deeper tissue taken from the area of concern in part 1. The deepest margin is inked orange according to the surgeon' s orientation. Two separate pieces of tan-brown soft tissue is also. present and measure 2 x 1.5 x 0.5 cm and 1 x 1 x 0.4 cm. The specimen is serially sectioned and entirely submitted as follows: 2A-B- salivary gland with deepest margin inked 2C- separate fragments of soft tissue Time in formalin- 32 hours. Part 3 is received fixed labeled with patient's name, initials xx, and "level 1A". It consists of adipose tissue and associated lymph nodes with an overall measurement of 4.3 x 4 x 1.5 cm. Several lymph nodes are identified and. range in size from 0.2 x 0.2 x 0.2 cm up to 1.0 x 0.6 x 0.5 cm. The lymph nodes are submitted in two cassettes labeled 3A and 3B.
+
+--- Page 3 ---
+Time in formalin- 1l hours. Part 4 is received fixed labeled with patients name, initials xx, and "right neck level 1B". It consists of adipose tissue, submandibular gland and. associated lymph nodes with an overall measurement of 5.7 x 4 x 2 cm. The submandibular gland measures 4.5 x 2.2 x 1.5 cm and is serially. sectioned to reveal a lobulated white parenchyma. Several lymph nodes are identified and range in size from 0.5 x 0.3 x 0.3 cm up to 1.2 x 1.2 x 1.0 cm. The specimen is submitted as follows: 4A- One lymph node bisected 4B- Lymph nodes 4C-D- representative sections of the submandibular gland. Time in formalin- 1l hours.. Part 5 is received fixed labeled with patient' s name, initials xx, and "right neck level 2, 3, 4, 5". The specimen consists of an unoriented radical neck dissection which measuresl3 x 8.5 x 3.5 cm, a separate piece of muscle which measures 4.5 x 3.8 x 2.0 cm and a separate piece of fibroadipose tissue which measures 4.5 x 2.0 x 0.8 cm. The radical neck dissection piece also contains a piece of muscle which measures 3.8 x 3.5 x 2.8 and a jugular vein (3.5 cm long and 0.7 cm in diameter). Between level 2 and 3 is a mass formed by two ill-defined nodules, one that is proximal (2.7x 2.2 x 1.7 cm) and another that is distal (2 x 1.7 x 1.5 cm). The proximal mass is adjacent to the jugular vein and the distal mass involves the muscle. The remaining fibroadipose tissue contains multiple lymph nodes (0.2 to 1.7 cm in maximal dimension). The piece of muscle that was separate grossly is not involved by tumor. Section Code: 5A- Level 2 lymph nodes 5B- Proximal mass 5C- Proximal mass and jugular vein 5D- Jugular vein proximal resection margin 5E- Jugular vein distal resection margin 5F-5G- Distal mass and muscle. 5H- Muscle proximal resection margin 5I- Muscle distal resection margin 5J-5K- Level 3 lymph nodes 5L-50- level 4and 5 lymph nodes (5L and 5M one lymph node in each, bisected) 5P- lymph nodes from separate fibroadipose tissue Time in formalin-ll hours. Part 6 is received fixed labeled with patient' s name, initials xx, and "left neck level 1B". It consists of adipose tissue, submandibular gland and
+
+--- Page 4 ---
+associated lymph nodes with an overall measurement of 5.5 x 4.5 x 2 cm.. The submandibular gland measures 5.0 x 4 x 3 cm and is serially sectioned. to reveal a lobulated white parenchyma. Two lymph nodes are identified and measure 1.0 x 0.7 x 0.3 cm and 1.4 x 0.7 x 0.5 cm. The specimen is submitted as follows: 6A- Lymph nodes 6B-c- representative sections of the submandibular gland. Time in formalin- 1l hours. Part 7 is received fixed labeled with patient' s name, initials xx, and "left neck level 2, 3, 4, stitch marks level 2". It consists of adipose tissue and associated lymph nodes with an overall measurement of 12.0 x 4.3 x 1.5. cm. Several lymph nodes are identified in level 2, 3, and 4 and range in size from 0.4 x 0.2 x 0.2 cm up to 2.0 x 1.0 x 1.0 cm. The lymph nodes are submitted as follows: 7A- One lymph node bisected, level 2 7B- level 2 lymph nodes 7C-D- level 3 lymph nodes 7E-G- level 4 lymph nodes Time in formalin- 1l hours.. INTRAOPERATIVE CONSULTATION: 1AFS: INFERIOR MUCOSAL MARGIN, RIGHT TONGUE (frozen seCtion): A. SUFFICIENT FOR ANCILLARY STUDIES. B. BENIGN. C . NO TUMOR SEEN MICROSCOPIC: Microscopic examination substantiates the above diagnosis.. The following statement applies to all immunohistochemistry, Insitu Hybridization Assays (Ish & Fish), Molecular Anatomic Pathology, and Immunofluorescent Testing:. The testing was developed and its performance characteristics determined by epartment of Pathology, as required by the the CLIA '88 regulations. The testing has not been cleared or approved for the  Tissue determined such approval is not necessary for clinical use. fixation ranges from a minimum of 2 to a maximum of 84 hours. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 ("cLIA") as qualified to perform high-complexity clinical testing. Pursuant to the requirements of CLIA, AsR's used in this laboratory have been established and verified for accuracy and precision. Additional information about this type of test is available upon request. CASE SYNOPSIS:
+
+--- Page 5 ---
+SYNOPTIC DATA - PRIMARY UPPER AERODIGESTIVE TRACT AND SALIVARY GLAND TUMORS SPECIMEN TYPE: Resection: hemigLossectomy TUMOR SITE: Oral Cavity TUMOR SIZE: Greatest dimension: 3.5 cm. HISTOLOGIC TYPE: Squamous cell carcinoma, conventional HISTOLOGIC GRADE: G2 PRIMARY TUMOR (pT): pT2 REGIONAL LYMPH NODES (pN) : pN2b Number of regional lymph nodes examined: 63 Number of regional lymph nodes involved: 2 Extra-capsular extension of nodal tumor:  Present DISTANT METASTASIS (pM) : pMX MARGINS: Margins uninvolved by tumor. VENOUS/LYMPHATIC (LARGE/SMALL VESSEL) INVASION (V/L) : Present PERINEURAL INVASION: Present PATIENT HISTORY: CHIEF COMPLAINT/PRE-OP/POST-OP DIAGNOSIS: Tongue Cancer pRoceDuRE: Right neck dissection, hemiglossectomy SPECIFIC CLINICAL QUESTION: Not given OUTSIDE TISSUE DIAGNOSIS: Not given PRIOR MALIGNANCY: Not given CHEMORADIATION: Not given ORGAN TRANSPLANT: Not given IMMUNOSUPPRESSION: Not given OTHER DISEASES: Not given HISTO TISSUE SUMMARY/SLIDES REVIEWED: Part 1: Right Glossectomy Stain, Block H&E x 1 A H&E x B H&E x c H&E  x 1 D H&E  x 1 E H&E x E H&E x 1 G H&E x 1 H H&E x 1 I H&E x 1 J Part 2: Right Floor of Mouth Stain Block H&E x 1 A H&E x 1 B H&E x 1 c Part 3:  Level 1A Stain, Block H&E x 1 A H&E x 1 B Part 4: Right Neck Level 1B
+
+--- Page 6 ---
+Stain Block H&E x 1 H&E x 1 B H&E x 1 c H&E x 1 D Part 5: Right Neck Dissection Levels 2-5 Stain Block H&E x A H&E x 1 B c H&E x 1 H&E 1 D H&E 1 [] H&E 1 E + H&E x 1 G H&E x H H&E x H 1 H&E x 1 J H&E x 1 K H&E x 1 L H&E M 1 H&E  x N H&E x 1 0 H&E x 1 P Part 6: Left Neck Level 1B. Stain. Block H&E x 1 A H&E x 1 H&E x 1 c Part 7: Left neck Level 2-4 Stain, Block H&E x 1 A H&E x 1 B H&E x 1 c H&E x 1 D H&E x E H&E x 1 F H&E x 1 G Lw 4a DISQUALIFIED
\ No newline at end of file
diff --git a/output/text/25568ffa-afe7-4b73-848d-c72c24a059f4.txt b/output/text/25568ffa-afe7-4b73-848d-c72c24a059f4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b4904ca9f0e64a3f2088aa68a5ae772e3734d9c2
--- /dev/null
+++ b/output/text/25568ffa-afe7-4b73-848d-c72c24a059f4.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+TSS ID TSS ID: Oc iD: Date of Procurement: Gross Description: Lump with the tumour of 1.4 x 1.2 cm in size; fatty tissue lymph nodes demonstrate lipomatosis Microscopic Description: Infiltrating duct carcinoma; G2. Ten dissected lymph nodes demonstrate hyalinosis, sinus histeocytosis, lipomatosis. Diagnosis Details: Tumor Features: Unknown, Tumor Extent: T1 tumor size 2 cm or less, Venous Invasion: Absent, Margins: Absent, Treatment Effect: Comments: 1Cs -0-3 Formatted Path Report: Site: bresst N0s BREAST TISSUE CHECKLIST C50.9 4/8/n Iu Specimen type: Lumpectomy Specimen size: Not specified. Tumor site: Upper outer quadrant. Tumor size: 1.2 x 0 x 1.4 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinoma Histologic grade: Moderately differentiated Tumor extent: Not specified Lymph nodes: 0/10 positive for metastasis (Axillary 0/10) Extracapsular invasion of the lymph nodes: Not specified. UUID:141B770B-22DD-4C87-AFF7-04D85FC9C74A Margins: Uninvolved TCGA-E9-A1R5-01A-PR Redacted Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified. Mitotic count (25x): Not specified. Mitotic count (40x): Not specified.
+
+--- Page 2 ---
+TSS ID Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified. Comments: None Laterality: Right, upper outer quadrant.
\ No newline at end of file
diff --git a/output/text/25580f58-a68c-4d21-8258-d4a9fdde33ea.txt b/output/text/25580f58-a68c-4d21-8258-d4a9fdde33ea.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3b6c01bd26442ce33f9b58dfa8d694e8c1322d54
--- /dev/null
+++ b/output/text/25580f58-a68c-4d21-8258-d4a9fdde33ea.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Chief of Pathology Phona Yax Specimen: Received: Status: Req#: Spec Type: SURGICAL P Subm Drt /cs-0-3 8520/3 Carcinorno, vnfiltrating 1obule,Nos LEFT BREAST CANCER INVASIVE Sih: breest, N0s C50.9 1/371nhw OPERATION PERFORMED DATE: DOCTOR (S) : PROCEDURE: STMPURMACIECOMYARXEXCGEONALSANANH ISSLE REOVED UUID:C385F075-864A-4D88-80C3-181FA28ACF4F TCGA-A2-A0YK-01A-PRE LT MASTECTOMY Redacted A. B. RT MASTECTOMY C. LT SENTINEL NODE #1 D. LT SENTINEL NODE #2 PART A RECEIVED LABELED LEFT MASTECTOMY STITCH AT 12 O'CLOCK, IS A SIMPLE MASTECTOMY SPECIMN MEASURING 15 X 15 X 3.5 CM IN GREATEST DIMENSIONS. THE NIPPLE IS IN THE INFERIOR PORTION OF A SKIN ELLIPSE MEASURING 9.7 X 5.5 CM IN GREATEST DIMENSIONS. A SUTURE DENOTES 12 O'CLOCK.  BLUE DYE IS NOTED IN THE SUPERIOR PORTION OF THE SPECIMEN. THE SUPERFICIAL MARGIN IS MARKED IN BLUE INK, THE DEEP MARGIN IN BLACK INK. SECTIONING REVEALS THE CENTRAL ASPECT OF THE BREAST TO CONSIST OF DENSE TAN FIBROUS TISSUE WITH FOCAL CYSTIC AREAS WITH BROWN MUCINOUS MATERIAL. THIS IS SURROUNDED BY BLAND YELLOW FATTY TISSUE AT THE PERIMETER. IN THE SUPERIOR 12 O'CLOCK AREA, THERE IS A DISTINCT PINK-TAN GRITTY AREA WITHIN THIS FIBROUS TISSUE WHICH MEASURES 1.6 X 1.3 X 3.5 CM, WHICH SPANS INTO THE 2 O'CLOCK AREA WHERE THERE IS FOCAL RED-TANS DISCOLORATION SUGGESTIVE OF PREVIOUS BIOPSY. GROSSLY, THESE AREAS OF FIRMNESS ARE CONTIGUOUS.  THIS LESION IS O.5 CM FROM THE DEEP MARGIN. WING CLIP IS IDENTIFIED IN THIS 12 O'CLOCK AREA. SECTIONS ARE SUBMITTED AS FOLLOWS: AI--SKIN AND NIPPLE, A2 AND 3--12 O'CLOCK LESION WITH DEEP MARGIN (MIRROR IMAGE TO PROTOCOL), A4--TISSUE SUPERFICIAL TO LESION TO INCLUDE SUPERFICIAL MARGIN AND SKIN, A5--2 O'CLOCK AREA (MIRROR~IMAGE TO PROTOCOL), A6--2 O'CLOCK AREA WITH DEEP MARGIN, A7--TISSUE SUPERFICIAL TO A8, A8--UPPER OUTER QUADRANT TISSUE BETWEEN THE 12:00 AND 2:00 AREAS (MIRROR IMAGE TO PROTOCOL), A9--UPPER INNER QUADRANT 2 CM FROM THE 12 O'CLOCK LESION, A10--LOWER INNER QUADRANT 3.5 CM FROM THE 12 O'CLOCK LESION, A11--LOWER OUTER QUADRANT 3.5 CM FROM THE 12 O'CLOCK LESION (NOTE: A9 THROUGH A1O ARE MIRROR IMAGES TO PROTOCOL SECTIONS).S A12--TISSUE FROM CENTRAL BREAST, A13--ADDITIONAL TISSUE LOWER OUTER QUADRANT . PART B RECEIVED LABELED RIGHT MASTECTOMY STITCH AT 12 O'CLOCK, IS A SIMPLE MASTECTOMY SPECIMEN WITH OVERALL DIMENSIONS OF 20 X 16.5 X 3.0 CM.  THE NIPPLE IS UNREMARKABLE AND SITS WITHIN A 9 X 4.5 CM SKIN ELLIPSE.  A SUTURE DENOTES 12 O'CLOCK.  THE SUPERFICIAL ASPECT IS MARKED IN BLUE, THE DEEP MARGIN IN BLACK INK. SECTIONING REVEALS THE
+
+--- Page 2 ---
+Chiof of Fathology Phone Yax Palantt Specimen: Received: Status: Rea# : Spec Type: SURGICAL P Subm Dr: GROSS DESCRIPTION (Continued) CENTRAL ASPECT OF THE BREAST TO CONSIST OF DENSE PINK-TAN FIBROUS TISSUE WITH FOCAL AREAS OF CYST FORMATION CONTAINING BROWN OILY MATERIAL.  THIS IS SURROUNDED BY A PERIMETER OF BLAND YELLOW FATTY TISSUE.S SECTIONS ARE SUBMITTED AS FOLLOWS:  B1--NIPPLE, B2--CENTRAL DEEP MARGIN, B3 AND 4--UPPER INNER QUADRANT, B5 AND 6--UPPER OUTER QUADRANT, B7 AND 8--LOWER OUTER QUADRANT, B9 AND 10--LOWER INNER QUADRANT. NOTE THAT B1, B3, B5, B7 AND B9 ARE MIRROR IMAGES TO PROTOCOL PIECES. PART C  RECEIVED FRESH LABELED LEFT SENTINEL NODE #1, IS AN OVOID PORTION OF BLUE-STAINED TISSUE AND YELLOW FAT MEASURING 2.1 X 1.7 X 1.0 CM. SECTIONING REVEALS A 1.0 CM IN DIAMETER GROSSLY UNREMARKABLE LYMPH NODE.   ONE-HALF IS SUBMITTED PER PROTOCOL; THE REMAINDER IS SUBMITTED LABELED C. PART D RECEIVED FRESH LABELED LEFT SENTINEL NODE #2, IS AN OVOID PORTION OF YELLOW FATTY TISSUE MEASURING 2 X 1.2 X 0.5 CM. SECTIONING REVEALS A O.6 CM IN DIAMETER GROSSLY UNREMARKABLE LYMPH NODE. THE TISSUE IS SUBMITTED ENTIRELY LABELED D. PATH PROCsDUReS : 88307/4, IMMUNOPEROXIDAS/2, A BLK/13, B BLK/10, CBX X3, DBX X3 FINALDIACNOI PART A LEFT BREAST, SIMPLE MASTECTOMY: 1. MULTICENTRIC IN SITU AND INVASIVE LOBULAR CARCINOMA OF BREAST, NUCLEAR GRADE II WITH MODERATE MITOTIC INDEX, WITH TUMOR IDENTIFIED IN THE PREVIOUSLY BIOPSIED SITES AND ALSO IN RANDOM SECTIONS FROM THE LOWER INNER QUADRANT, CENTRAL BREAST AND NIPPLE SKIN. 2. THE TUMOR NODULES MEASURE IN SIZE FROM 2 MM TO 35 MM (GROSSLY). THE DEEP MARGIN IS FREE OF NEOPLASM. 3. LYMPHATIC INVASION IS NOT IDENTIFIED. 4. A SMALL INTRAMAMMARY LYMPH NODE (1) IS NEGATIVE FOR TUMOR (SLIDE A7). FIBROCYSTIC DISEASE WITH DENSE FIBROSIS AND FIBROADENOMA.S 5. PART B RIGHT BREAST, SIMPLE MASTECTOMY: PROLIFERATIVE FIBROCYSTIC DISEASE WITH DENSE FIBROSIS, SCLEROSING ADENOSIS, APOCRINE METAPLASIA, CYST FORMATION AND RADIAL SCAR FORMATION. MICROCALCIFICATIONS ARE PRESENT. ATYPIA OR MALIGNANCY IS NOT IDENTIFIED. PART C LEFT SENTINEL NODE #1, BIOPSY: LYMPH NODE (1), NEGATIVE FOR
+
+--- Page 3 ---
+Phone Pent Specimen: Received: Status: Req#: Spec Type: SURGICAL P Subm Dr: (Continued) TUMOR BY STEP SECTION AND CYTOKERATIN STAIN. A FOCUS OF PERINODAL FIBROSIS IS PRESENT WHICH MAY REPRESENT A PREVIOUS BIOPSY SITE. PART D LEFT SENTINEL NODE #2, BIOPSY: LYMPH NODE (1), NEGATIVE FOR TUMOR BY STEP SECTION AND CYTOKERATIN STAIN. Signed (prelim.) (signature on file)
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diff --git a/output/text/257a1397-f9fb-46f2-9267-22ed385e2c15.txt b/output/text/257a1397-f9fb-46f2-9267-22ed385e2c15.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2411e234b1f9fcfe9786b8b96c5218556dc1ebf0
--- /dev/null
+++ b/output/text/257a1397-f9fb-46f2-9267-22ed385e2c15.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+SPECIMENS: A. TERMINAL ILEUM AND RIGHT COLON DIAGNOSIS: A. RIGHT COLON AND TERMINAL ILEUM, RESECTION: - INFILTRATING MODERATELY DIFFERENTIATED COLON ADENOCARCINOMA (2.2 CM) INVOLVING THE SUBSEROSA. - SIXTEEN BENIGN LYMPH NODES (0/16). SEE TEMPLATE  SURGICAL MARGINS ARE NOT INVOLVED - MULTIPLE HYPERPLASTIC POLYPS AND SMALL TUBULAR ADENOMA COLORECTAL CANCER TEMPLATE Specimen Type: Right hemicolectomy Tumor Site: Ascending colon Tumor Configuration:  Ulcerating with indurated edge Tumor Size: 2.2 cm Histological Type: Adenocarcinoma Histological Grade: Moderate-poorly differentiated Extent of Invasion: Subserosa Margins: Uninvolved Distance to Closest Margin: 0.6 cm from radial margin Angiolymphatic Invasion: Absent Perineural Invasion: Absent Additional Findings: Hyperplastic polyps and minute tubular adenoma Extent of Resection: RO: Complete Lymph Nodes: Negative: 0/16 Implants: Absent Pathological Stage: pT3a N0 MX SPECIMEN(S): A. TERMINAL ILEUM AND RIGHT COLON CLINICAL HISTORY: Not given GROSS DESCRIPTION: A. TERMINAL ILEUM AND RIGHT COLON Received fresh and labeled as "terminal ileum and right colon". Received is a closed segment of colon and terminal ileum measuring 26.4 cm in length. There is a constricted portion of the right colon located at the mid segment. This entire segment is inked blue. The terminal ileum measures approximately 4.6. x 4.1 cm and the right colon measures 22.0 cm in length and 6.0 cm in diameter. There is an ulcerated tumor mass measuring 2.2 x 2.2 x 0.6 cm which extends through the muscularis propria. The tumor is situated in the colon and is located 11.0 cm from the proximal margin and 13.0 cm from the distal. colonic margin. There are several polyps present throughout the right colon ranging in size from 0.1 to 0.7 cm. Sections are taken for tissue procurement and gross photograph was also taken. Representative sections are submitted as follows: A1: shaved sections of proximal margin A2: shaved sections of distal margin A3-A11: mass, including deep margin A12: polyps A13: normal-appearing colonic mucosa. A14-A17: possible lymph nodes A18: normal-appearing tissue from ileum
\ No newline at end of file
diff --git a/output/text/259edb0a-1a52-4b12-ab22-11641e9abd7a.txt b/output/text/259edb0a-1a52-4b12-ab22-11641e9abd7a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5e76ee8728d2af7f5aaf5937a0230e01355e33df
--- /dev/null
+++ b/output/text/259edb0a-1a52-4b12-ab22-11641e9abd7a.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+, Path (First Tumor). Tumor Site: Sigmoid Distal Date of Cancer Sample Procurement: Histology: Adenocarcinoma Description of other histology: Grade: Mucinous: C No C Yes ( Yes (Focal) C Unknown Signet Ring Feature: C No r Yes  Yes (Focal) C Unknown Histologic Heterogeneity: C No ( Yes r Unknown Host Response:. Crohn's like reaction  None C Yes C Unknown Plasma cell rich stroma C No  Yes c: Unknown ( Invasive C Expansile Growth Pattern: ^ Expansile C Unknown and Invasive Inflammatory Bowel Disease 6 No C Yes r~ Unknown Angiolymphatic Invasion:. C No ( Yes * Unknown Mutator Phenotype: r No C. Yes r Unknown Number of Slides Garland Necrosis present: C No C Yes  Yes (Focal) C Unknown TiL Cells / HPF Pathologist Comment: 1co - 0- 3 adenscuuimmr, N0s 8140f3 pw 5hgn Sit, anon,Sigmo.tL Cig.7 UUID:8C4517E8-8E37-4BA2-AF3B-5621F1C572A8 TCGA-DM-A28C-01A-PR Redacted
\ No newline at end of file
diff --git a/output/text/259f4162-fbee-4756-b39b-b7cac6fe422f.txt b/output/text/259f4162-fbee-4756-b39b-b7cac6fe422f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..30e5de3dbdabd18f39cb0816f51ab2f3ca49530b
--- /dev/null
+++ b/output/text/259f4162-fbee-4756-b39b-b7cac6fe422f.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+Surgical Pathology Report. * Revised * Name: Case #: DOb: Collected: Gender: F Recelved: MRN: Reported: Location: Copy To: Physiclan: Pathologic Interpretation: 1cs -0 - 3 AmEnDment, Carciomn, nifptrathy duchl, nos! 8500/3 A. SUpeRiOr medial mArgin, RULE OUt TUmOR: Iit; buast, Nos C5U.9 3/fn - No malignancy seen. B. SENTINeL NODE #1: - Microscopic foci of carcinoma are highlighted by Keratin (1/1). c. SENTINEL NODE #2: - No malignancy seen in one lymph node (0/1). - Immunohlstochemistry for keratin is negatlve for carcinoma. D. SENTINEL NODE #3: - Metastatic carcinoma to one lymph node (1/1) with extracapsular extension. E. RIght BReaST mASS: - Invasive ductal carcinoma Nottingham grade 2 (3+2+1); 4.2 cm in greatest dimension. - Specimen margins are negative for tumor closest margins are anterior and superior, 0.2 cm (See Tumor Summary). - Lymphovascular invasion is identified. F. AdDiTIonal AxiLLAry fat: - No malignancy seen in one lymph node (0/1). G. ADDITIONAL SUPERIOR MArGIN: - Microscopic focus of invasive ductal carcinoma, 0.1 cm, adjacent to inked resection margin. - The focus of invasive carcinoma is present at the inked margin adjacent to previous resection.. - The "new" inked margin is free of tumor. - Lymphatic tumor emboli are identified. H. RIGHT AXILLARY CONTENTS: - No malignancy seen in nineteen lymph nodes (0/19) ADDItIONAL AXILLARy CONTeNTS LEVel 2-3 LymPh NODeS: - No malignancy seen in two iymph nodes (0/2). Tumor Summary: UUID:6FEAD496-58BA-42DC-A3F2-2F380EEB1588 Specimen: TCGA-EW-A1P6-01A-PR Redacted . Partial breast Procedure: - Excision without wire-guided localization. Lymph Node Sampling: - Sentinel lymph nodes - Axillary dissection Specimen Integrity: - Multiple designated specimens Specimen Size: - Greatest dimension: 8.5 cm * Additional dimension: 6 x 5 cm. Laterality: Right Tumor Size:
+
+--- Page 2 ---
+SURGICAL PATHOL Report - Greatest dimension of largest focus of invasion over 0.1 cm: 4.2 cm. - Additional dimensions: 3.8 x 2.8 cm. Tumor Focality: - Single focus of invasive carcinoma. Macroscopic and Mlcroscopic Extent of tumor: - Skin: Skin is not present. - Skeletal muscle: No skeletal muscle present Lobular Carcinoma IN Situ (LCIS): - Not identified Histologic Type of Invasive Carcinoma: - Invasive ductal carcinoma Histologic Grade: - Glandular (Acinar)/Tubular Differentiation: - Score 3: <10% of tumor area forming glandular/tubular structures - Nuclear Pleomorphism:  - Score 2: Cells larger than normal with open vesicuiar nuclei, visible nucleoli, and moderate variability in botn size and Shape - Mitotic Count: - Score 1 - Overall Grade: - Grade 2: scores of 6 or 7 Margins: - Margins negative for invasive carcinoma. Lymph-Vascular Invasion: - Present Lymph Nodes: - Number of sentinel lymph nodes examined: 3  - Total number of lymph nodes examined (sentinel and Nonsentinel): 25 - Number of lymph nodes with macrometastases (>0.2 cm): 2 Extranodai Extension: - Present Method of Evaluation of Sentinel Lymph Nodes: - Hematoxylin and eosin (H&E), one level - Immunohistochemistry Pathologic Staging: - Primary Tumor: pT2: Tumor >20 mm but 50 mm in greatest dimension - Regional Lymph Nodes: pN1a: Metastases in 1 to 3 axillary lymph nodes, at least 1 metastasis greater than 2.0 mm - Distant Metastasis: Not applicable Ancillary Studies: Estrogen Receptor: Results: Immunoreactive tumor cells present (1%) . Performed on another specimen: Progesterone Receptor. Results: Immunoreactive tumor cells present (1%)  - Performed on another specimen: HER2/neu Results: Negative (Score 0) . Performed on another specimen: Cllnica! History: - Palpable mass Pathologic Staging (pTNM): pT2, N1a, M-not applicable PREVIOUSLY ISSUED DIAGNOSIS: A. SUPERIOR MEDIAL MARGIN, RULE OUT TUMOR: - No malignancy seen. B. SENTINeL nODE #1: - No malignancy seen in one lymph node (0/1). - Immunohistochemistry for keratin to follow. C. SENTINEL NODE #2:  Page 2 of 6
+
+--- Page 3 ---
+SURGICAL PATHOL Report - No malignancy seen in one lymph node (0/1).. - Immunohistochemistry for keratin to follow.. D. SENTINEL NODE #3: - Metastatic carcinoma to one lymph node (1/1) with extracapsular extension. E. RIGht BREaSt mASS: - Invasive ductal carcinoma Nottingham grade 2 (3+2+1); 4.2 cm in greatest dimension. - Specimen margins are negative for tumor closest margins are anterior and superior, 0.2 cm (See Tumor Summary). - Lymphovascular invasion is identified.. F. ADDITIONAL AXiLLARY FAT: - No malignancy seen in one lymph node (0/1). G. ADDITIONAL SUPERIOR MARGIN: - Microscopic focus of invasive ducta! carcinoma, 0.1 cm, adjacent to inked resection margin. - Lymphatic tumor emboli are identified.. H. RighT AxILLaRy ContentS: - No malignancy seen in nineteen lymph nodes (0/19) I. ADDITIONAL AXILLARY CONTENTS LEVEL 2-3 LYMPH NODES: - No malignancy seen in two lymph nodes (0/2). Tumor Summary: Specimen: - Partial breast Procedure: - Excision without wire-guided localization. Lymph Node Sampling: - Sentinel lymph nodes - Axillary dissection Specimen Integrity:d - Muitiple designated specimens Specimen Size: - Greatest dimension: 8.5 cm * Additional dimension: 6 x 5 cm. Laterality: - Right Tumor Size: - Greatest dimension of largest focus of invasion over 0.1 cm: 4.2 cm. - Additional dimensions: 3.8 x 2.8 cm.. Tumor Focality: - Single focus of invasive carcinoma. Macroscopic and Microscopic Extent of tumor: - Skin: Skin is not present.. - Skeletal muscle: No skeletal muscle present. Lobular Carcinoma IN Situ (LCIS): - Not identified Histologic Type of Invasive Carcinoma:. - Invasive ductal carcinoma Histologic Grade: - Glandular (Acinar)/Tubular Differentiation: - Score 3: <10% of tumor area forming glandular/tubular structures - Nuclear Pleomorphism: - Score 2: Cells larger than normal with open vesicular nuclei, visible nucteoli, and moderate variability in bothsize and  Shape - Mitotic Count: - Score 1 - Overall Grade: - Grade 2: scores of 6 or 7. Margins: Page 3 of 6
+
+--- Page 4 ---
+SURGICAL PATHOL Report - Margins positive for invasive carcinoma.. - Specify margin and Extent of involvement: Superior margin, focal. Lymph-Vascular Invasion: - Present Lymph Nodes: - Number of sentinel lymph nodes examined: 3 - Total number of lymph nodes examined (sentinel and Nonsentinel): 25 - Number of lymph nodes with macrometastases (>0.2 cm): 1 Extranodal Extension: - Present Method of Evaluation of Sentinei Lymph Nodes:. - Hematoxylin and eosin (H&E). one level. - Immunohistochemistry Pathologic Staging: - Primary Tumor: pT2: Tumor >20 mm but 50 mm in greatest dimension - Regional Lymph Nodes: pN1a: Metastases in 1 to 3 axillary lymph nodes, at least 1 metastasis greater than 2.0 mn.  Distant Metastasis: Not applicable Ancillary Studies:d Estrogen Receptor. - Performert n another specimen Results: Immunoreactive tumor cells present (1%) Progesterone  ..or: ied on another specimen: Results: Immunoreactive tumor cells present (1%) - HeR? "med on another specimen: Results: Negative (Score 0) Clinicai History: - Palpable mass Pathologic Staging (pTNM): pT2, N1a, M-not applicable t spectfic reagems (ASRs) validaked by ou that dn xx require FDA app .7 closore d NOTE: JDS-FR Pgl636-PR,A$85-H I All immannhstochemial. tate n dwih for Method The rsuls are read hy a  pathlogiu as positive or negasive As the attending pathologist, I attest that I: (i) Examined the relevant preparation(s) for the specimen(s): and (ii) Rendered the diagnosis(es).. MD ***Electronically Signed Out By*** Amendmentsd Amended by Reason: Diagnosis editing/clarification New information provided to Dr. by physician. Previous Signout Date:. Intraoperative Consultation A. Superior medial margin, rule out tumor, FS: No tumor seen. B. Sentinel node #1, FS: Negative for carcinoma (touch prep and frozen). C. Sentinel node #2, FS: Negative for carcinoma (touch prep and frozen) D. Sentinel node #3, FS: Atypical cells on touch prep-carcinoma cannot be excluded.. FS: Metastatic carcinoma in lymph node.. : MD Page 4 of 6
+
+--- Page 5 ---
+SURGICAL PATHOL Report MD Clinical History: female with right breast mass. Biopsy shows invasive ductal carcinoma Operation Performed Lumpectomy right breast with sentinel node. Pre Qperative Dlagnosis: Breast cancer Specimen(s) Received: A: Superior medial margin, rule out tumor, FS. B: Sentinel node #1, FS C: Sentinel node #2, FS D: Sentinel node #3, FS E: Right breast mass F: Additional axillary fat G: Additional superior margin H: Right axillary contents I: Additional axillary contents level 2-3 lymph nodes. Gross Description: A. Received fresh are two yellow-tan tissue fragments, measuring up to 1.0 cm in length. In toto in one casset'e for frozen. B. Received fresh is a light brown lymph node 1.5 x 1.0 cm. in toto in one cassette for frozen. C. Received fresh is a lymph node, measuring 2.0 x 1.5 cm. In toto in one cassette for frozen. D. Received fresh is a tymph node, measuring t.2 x 1.0 cm. In toto in one cassette for frozen. E. Received in formalin is a yellow-tan fibroadipose tissue fragment, weighing 89 grams, measuring 8.5 x 6.0 x 5.0 cm. The. specimen is oriented with a short superior, long lateral and double stitch deep margin. Inked as follows: Supprior in blue,. inferior in green, deep black, anterior yellow, lateral orange and medial red. Cross section through the specimen shows. yellow-tan cut surface. There is an ovoid, markedly firm, tumoral mass, measuring 4.2 x 3.8 x 2.8 cm. The nass is within 2 mm from superior and anterior inferior margin. No other firm masses were grossly identified. Sections submitted. as follows: 1&2 Composite resection of the largest axis of the mass from antero-inferior to superior margin 3-5 Additional section of the mass in relation with the antero-inferior margin 6&7 Section of the mass in relation with the deep resection margin 8 Mediat margin 9 Lateral margin F. Received in formalin are muitiple yellow-tan adipose tissue fragments, measuring 6.0 x 4.0 x 1.0 cm in aggregate. No lymph nodes were grossly identified. Sections from the fat tissue in three cassettes. G.  Received in formalin is a yellow-tan adipose tissue fragment (additional superior margin), measuring 6.0 x 3.q x 1.0 cm. Multiple sutures orient the specimen as a true margin. The true margin in green. The opposite margin in black. Cross section through the specimen shows a yellow-tan cut surface. No masses were grossly present. Submitted in toto in eight cassettes. H. Received in formalin are multiple yellow-tan fibroadipose tissue fragments, measuring 10.0 x 7.0 x 3.0 cm in aggregates.. Twenty lymph nodes are present, measuring up to 0.8 x 0.7 cm in greatest dimension. Sections as follows: Two lymph nodes in toto 2-8 Three lymph nodes in toto per cassette. I. Received are multiple yellow-tan fibroadipose tissue fragments, measuring 5.0 x 3.0 x 1.0 cm. Four lymph nodes are identified, measuring up to 0.6 x 0.4 cm. Sections as follows:. 1&2 Two lymph nodes in toto per cassette DSQUAFED Page 5 ot 6
+
+--- Page 6 ---
+SUrgical PathoL Report Page 6 of 6
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diff --git a/output/text/25d7b0a1-cb8c-4320-a8ae-27ad88cb9d35.txt b/output/text/25d7b0a1-cb8c-4320-a8ae-27ad88cb9d35.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2b724f21e3c83aae6f5408d45ec6a4d9eb734fe8
--- /dev/null
+++ b/output/text/25d7b0a1-cb8c-4320-a8ae-27ad88cb9d35.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SURGICALPATHOLOGY SPECIMEN A. KIDNEY - 1. Left kidney mass (margin measurments) Genome project 1243 p.m. CLINICAL INFORMATION Left kidney mass. GROSS DESCRIPTION The snecimen is received fresh in frozen section room labeled with the patient's name. d additionally labeled "left kidney mass" and consists of a 4.5 x 3.1 x 3 cmT kidney covered by adipose tissue, measuring 7 x 3.5 x 1 cm. There is a 2.4 cm in maximal diameter tan Iobulated mass, which is located 0.5 cm from the surgical margin. The surgical kidney margin is inked black and the renal capsule is inked red. A representative section is submitted for frozen section interpretation The frozen section residual is submitted in cassette (A1). The remainder of the lesion is submitted in cassettes (A2)-(A6).. Frozen section diagnosis: FSA1 -- "Primary renal neoplasm. Margin negative, 0.5 cm from tumor.". MICROSCOPIC DESCRIPTION The frozen section diagnosis is confirmed. The primary renal neoplasm is a type 2 papillary renal cell carcinoma, Fuhrman nuclear grade 3. The tumor is confined to the kidney with a predominately pseudo solid appearance due to compression of papillae and tubules. Aggregates of foamy macrophages and focal areas of papillae with fibrovascular cores and scattered psammoma bodies are present. The tumor has a somewhat biphasic appearance with an admixture of cells with round, more uniform nuclei and scant cytoplasm and cells with enlarged, irregular nuclei with focally prominent nucleoli and moderate amounts of eosinophilic cytoplasm. The tumor is 0.55 cm from the kidney margin and does not penetrate the renal capsule. Mild arteriosclerosis is seen in the adjacent uninvolved kidney.
+
+--- Page 2 ---
+SPECIMEN TYPE: Left partial nephrectomy. TUMOR SIZE: 2.4 cm. MACROSCOPIC EXTENT OF TUMOR: Limited to kidney. HISTOLOGIC TYPE: Papillary renal carcinoma.. HISTOLOGIC GRADE: G3. EXTENT OF INVASION: T1. MARGINS: Margins uninvolved by tumor (0.55 cm from kidney margin) BLOOD/LYMPHATIC VESSEL INVASION: Absent. REGIONAL LYMPH NODES: NX. DISTANT METASTASIS: MX. ADnITIONAI PATHOLOGIC FINDINGS: Mild arteriosclerosis. FINAL DIAGNOSIS KIDNEY, LEFT, PARTIAL NEPHRECTOMY  Papillary renal cell carcinoma. Tumor size 2.4 cm. Fuhrman nuclear grade 3.  Surgical margins negative.  Mild arteriosclerosis. CPT CODE(S): 88307x1, 88331x1
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diff --git a/output/text/25dae3a9-a474-4c92-b1ad-1819e972683f.txt b/output/text/25dae3a9-a474-4c92-b1ad-1819e972683f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d0c51110c7d581cf70aab6c8f460e562d1a5921b
--- /dev/null
+++ b/output/text/25dae3a9-a474-4c92-b1ad-1819e972683f.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis Resected ileocolic sample with an ulcerated, moderately differentiated adenocarcinoma of the colorectal type, measuring max. 7 cm in diameter, covering the cecum extensively, with broad infiltration of the pericecal fatty tissue, circumscribed penetration of the covering. serosa and 14 local lymph node metastases. Tumor-free small and large intestine resection margins. Tumor-free mesenteric resection margin. Tumor-free appendix.. The tumor stage is pT4 pN2 (14/28) pM1 (clinical liver metastases); G2 L1, V0, R2
\ No newline at end of file
diff --git a/output/text/2629fb0d-9e6a-4b75-9aac-25eb94d2c49c.txt b/output/text/2629fb0d-9e6a-4b75-9aac-25eb94d2c49c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..34998fa477a02dc0d9d1ef21fdf93e7feb28f331
--- /dev/null
+++ b/output/text/2629fb0d-9e6a-4b75-9aac-25eb94d2c49c.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+DIAGNOSIS (A) LEFT MENTAL NERVE: Segment of nerve, no tumor present. (B) PARTIAL MANDIBULECTOMY, RESECTION: DEEPLY INVASIVE SQUAMOUS CELL CARCINOMA, MODERATELY DIFFERENTIATED (3.5 CM) WITH PLEURAL INVASION. PERINEURAL INVASION SEEN. (C) RIGHT VENTRAL TONGUE MARGIN: Squamous mucosa, no tumor present. (D) LEFT VENTRAL TONGUE MARGIN: Squamous mucosa, no tumor present. (E) RIGHT ALVEOLAR RIDGE MARGIN: Squamous mucosa, no tumor present. (F) LEFT ALVEOLAR RIDGE MARGIN: SQUAMOUS MUCOSA WITH INVASIVE SQUAMOUS CELL CARCINOMA. (G) LEFT NEW ALVEOLAR RIDGE MARGIN: Squamous mucosa with focal dysplasia, no tumor present. (H) NEW RIGHT ALVEOLAR RIDGE MARGIN: Squamous mucosa, no tumor present. Entire report and diagnosis completed b GROSS DESCRIPTION (A) LEFT MENTAL NERVE, CHECK PERINEURAL INVASlON - A tan-white nerve (0,9 x 0.2 x 0.2 cm) that is unremarkable. No orientation information is given. Submitted entirely for frozen sectig *FS/DX: SEGMENT OF NERVE, NO TUMOR PRESENT. (B) PARTIAL MANDIBULECTOMY - A portion of mandibulectomy and attached white-tan skin with overall measurements of 9.0 x 4.5 x 5.0 cm. The skin is light tan, intact and hairbearing (5.5 cm in width and 9.5 cm length). The upper mucosal aspect of the specimen has an ulcerated deeply invasive lesion measuring 2.0 x 1.0 x approximately 3.5 cm. The tumor is light tan, firm and involves the cortical bone and extends to the soft tissue mass that infiltrates the skin. The bony margin appears unremarkable and the soft tissue margin grossly unremarkable. The specimen is submitted from anterior to posterior under B1-B11 and B12, B13, skin and tumor; B14, representative section of tumor; B15, another representative section of skin and tumor.. (C) RIGHT VENTRAL TONGUE MARGIN-A piece of mucosa measuring2.6 x 0.2 x 0.2 cm. Blue ink is present designating the true margin. The mucosa is tan and glistening with no lesion. The specimen is submitted entirely en face for frozen section examination. Page 1 of 3 Surgical Pathology Report File under: Pathology
+
+--- Page 2 ---
+*FS/DX: SQUAMOUS MUCOSA, NO TUMOR PRESENT. (D) LEFT VENTRAL TONGUE MARGIN - A strip of mucosa measuring 2.2 x 0.3 x 0.2 cm. Blue ink is identified designating the true margin. The specimen is entirely submitted en face in cassette D for frozen section examination.. *FS/DX: SQUAMOUS MUCOSA, NO TUMOR PRESENT. (E) RIGHT ALVEOLAR RlDGE-A rim of mucosa measuring 2.3 x 0.3 x 0.2 cm.Blue ink is identified designating the true margin. The specimen is entirely submitted with the margin en face in cassette E for frozen examination. *FS/DX:SQUAMOUS MUCOSA, NO TUMOR PRESENT. (F) LEFT ALVEOLARRIDGE MARGIN-A piece of mucosa measuring 2.4 x 0.3 x 0.3 cm. The mucosa is unremarkable. Edge of blue ink is identified desianating the true margin.The specimen is submitted entirely with the margins en face in cassette F for frozen examination. *FS/DX: INVASIVE SQUAMOUS CELL CARCINOMA (G) LEFT NEW ALVEOLAR RIDGE MARGIN -A piece of mucosa measuring2.2 x 0.8 x 0.3 cm which has unremarkable mucosa.An edge with blue ink is present designating the r ew true margin. The mucosal margin is trimmed out and put entirely with ink en face in cassette G for frozen examination. *FS/DX: FOCAL DYSPLASIA. NO INVASIVE CARCINOMA H NEW RIGHT ALVEOLAR RIDGE-A tan-pink soft tissue fragment 1.2 x 1.0 x 0.4 cm). The cut surface is unremarkable INKCODE: Blue = new resection margin. SECTION CODE: H, perpendicular sections of the entire specimen. CLINICAL HISTORY None given. Released by: Page2of3 Surgical Pathology Report File under: Pathology
+
+--- Page 3 ---
+ADDENDUM DIAGNOSIS: (B) PARTIAL MANDIBULECTOMY, RESECTION: SQUAMOUS CELL CARCINOMA IN SOFT TISSUE EXTENDING TO CORTICAL BONE, BONE FREE OF TUMOR. Entire report and diagnosis completed by GROSS: B) PARTIAL MANDIBULECTOMY -A portion of mandibulectomy and attached white-tan skin with overall measurements of 9.0 x 4.5 x 5.0 cm. The skin is light tan, intact and hair bearing (5.5 cm in width and 9.5 cm length). The upper mucosal aspect of the specimen has an ulcerated deeply invasive lesion measuring 2.0 x 1.0 x approximately 3.5 cm. The tumor is light tan, firm and involves the cortical bone and extends to the soft tissue mass that infiltrates the skin. The bony margin appears unremarkable and the soft tissue margin grossly unremarkable. The specimen is submitted from anterior to posterior under B1-B11 and B12, B13, skin and tumor: B14. representative section of tumor; B15, another representative section of skin and tumor; B16-B20, samples of bone. Released by: Page 3 of 3 Surgical Pathology Report File under: Pathology
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diff --git a/output/text/268e1cc3-db8d-4bfb-8cfc-890b7491c4fe.txt b/output/text/268e1cc3-db8d-4bfb-8cfc-890b7491c4fe.txt
new file mode 100644
index 0000000000000000000000000000000000000000..291e6a975cc859ea9469b8d086dd3dc1d2605816
--- /dev/null
+++ b/output/text/268e1cc3-db8d-4bfb-8cfc-890b7491c4fe.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+PATHOLOGTC DIAGNOSIS: LEFT K:DNEY,NEMIRECTOMY: RENAL CHI.CARCINOMA CHROMOHOBF TYPE,Fhrm Huciar yraCe IV of I1l. cm. Extonsive tumor rerosis with calcifcation is present. Frecuent mtoses are present. The carc.noma invadcs into adipose tissue at tc hilum. Th carcinoma invaces inrc tu pe vis of tne kidncy The carcinoma is confined by the capsule Synphovascala :nvasion is present. The artery,yen, and uretera! argns are frca cf carcinoma The ronecplaste renal parenchyma wil be cxamined wth speoia stains and tle Iindinyy roported in an addcnd. CJ.INICAL CATA: Hissory: None given. Cyera:.on: Lof hand-assisted laparcscopic nephrectomy cinica Diagnosis: Left renalnass. TISSVE SUBMITTED: A/1 left kidney (s.s.). GROSS DESCRIFTON The sgccimen is received fresh, labcled with the patients name, unit number, and let kdncyand coneist ot an 659.gram kidney measuriy 29.C x 12.57.8 cm wit a creter ll.0 cm in lengh x c.7 cr. in diamcterurtery cameer The specme Is inkcd h aek and bivalved to roveal a cltilobuared can/yellow/pink he.crcgeeous cass, mearing1.510.5 whc as located in rhe .cwer  and abuts tne kidrcy cupsule. T.C mas .4 cn ro the artery, anc 12.5 cm 1 th ucter. The mass is predominantly solid with aome arcas cf cystic degcrerution There d remorrhage. Sank for special studies Representative sections ot the grossly norma kicney parenchyma are submitted for immunotaorescence, clectron miaroscopy and ssue Bank tor special sudes Gross phctcgrapha are taken MFTO A ugins. rena! artury, veinreter, 3 tr Mro A2-A4 representative sect.onn of tmor, 3 fragg Mi A5A6 blood clot feund ir rena poivas2 fags Miro A-A9 cunor in relatonship no renal capsu.e and adipose tissue. Eruga.RSS. Pave lat
+
+--- Page 2 ---
+Micro Alo-Al: tumer in relationship to distai renal Micro A12 more proximal renal vein, 1 frag 2 frags Micro A3 normal kidney parenchyma, frag Ry hs/her sgrature below. the sen.or physician cerisies that he/sh persoraly conducted a microscopic cxamination gross only" exam i so state ADDENDSM: RENAL PATHCLOGY FVASUATTON O KIDNEY PARENCHYMA: LEFT KIDNEY. NEPHRECTOMY: GHOMRCLI WI SGNS OF HYPERTROPHY AND MID MESANGIAL FXPANSION SUGGESTIVE CF AN EARLY DIFFUSE DIABETIC GLOMERULCSCLEROSIS SEE NOTE MENIMAL CHRONC CHANGES OF THE KIDNEY FARENCHYMA,MOST LKELY AGE RELATFD FOCAIGLCSAL CLOMERLOSCLEROSTS 4 OF LOMERL TUBULAR ATRCPHY AND INTERSTITTAL FIBROSIS LMSS THAN S O THE FASENCHYMA -ARTERIAL SCIEROSIS ANID ARTERIOIAR HYAI.TNCSISMCDERATE (SEE NOTE) HOTE: The y omerui reveni m ld s.gns of hypertrophy ol the tuft and mild expansion f the mesangia marix ahough there charges aro rather non-specific they ggess an ncipcnt or carly ditfusc diabntlc yiomeru csclerosis since the patient's chart roveal abncrmal levcis of serum gluccsc. The ovcraii kidncy puronchyma sample cxamined shows minor chronic changes within the expected range for a 50-yearold man. There is minimal focal gonal glomerulosclerosis (4 cf gcnerali). and minsmai tnbular atroply and irterssitia fibrosis less a 5t of the parenchma). liowever, the arterial and arteriolar vesseis reveal  moderate degree ot vascular sclerosis or scarrng The kidney parenchyma ras beon reviewod by Renal Patho ogists. MCROSCOPC DESCRPTCN Soctions of formalin-fixed paraffin embedded sissuc (block Al3 were cvalated sing Hn. As. Jones sver methenamine. and AFoc trichrome) stains. The sampi conssts cf otcx and medua. whch6(4t are g.cbnlysclerosed. Thore ar 5i glomcruli presen.,o cf lyperrrophy wih also mid expansion ct thc mcsargial areas by matrix The remainny glomeruli show mild signs ecmonts. There are no discernible craters or double contours of the lcroralar capil ary wall basement membranos on PAs and Jones' slver stain. Ra distal cbu es ccntain pAs-postive hyainn casts. There is fcca atrophy Focal cxtravasation of Tamm-Horsfal proein is also recoynized. Less an s o the cortica! parenchyma shows cubnlax Fihros: as sccn on trichrore stain Aroo atrophy ard interstitia! mcdorae degree o scleros re.2
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diff --git a/output/text/272e3722-af5d-4dc7-b76f-d433850aa252.txt b/output/text/272e3722-af5d-4dc7-b76f-d433850aa252.txt
new file mode 100644
index 0000000000000000000000000000000000000000..71835f7047a00044a67cadc67eb6d2afc4bb9a0d
--- /dev/null
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+
+--- Page 1 ---
+larunonn, m~flt^utiNg 1obulw 85aoJ TSS: Site Codu: buist, Nos e50.9 12 124f10 tss: UUID:EDD254CA-0EC6-42F8-B213-C2D386AB11F4 TCGA-E2-A1B5-01A-PR Redacted SPECIMENS: A. LEFT AXILLARY SENTINEL LYMPH NODE #1 B. LEFT AXILLARY SENTINEL LYMPH NODE #2 C. LEFT AXILLARY SENTINEL LYMPH NODE 3# D. WLE LEFT BREAST NEEDLE LOCALIZATION E. ADDITIONAL RETROAREOLAR TISSUE LEFT BREAST F. LEFT AXILLARY LYMPH NODES SPECIMEN(S): A. LEFT AXILLARY SENTINEL LYMPH NODE #1 B. LEFT AXILLARY SENTINEL LYMPH NODE #2 C. LEFT AXILLARY SENTINEL LYMPH NODE 3# D. WLE LEFT BREAST NEEDLE LOCALIZATION E. ADDITIONAL RETROAREOLAR TISSUE LEFT BREAST F. LEFT AXILLARY LYMPH NODES GROSS DESCRIPTION: A. LEFT AXILLARY SENTINEL LYMPH NODE #1 Received fresh is a tan pink lymph node 1.5 x 0.8 x 0.5cm. The specimen is serially sectioned and a touch prep is taken. Toto A1. B. LEFT AXiLLARY SENTINEL LYMPH NODE #2 Received fresh is a tan pink lymph node 1.0 x 0.8 x 0.6cm. The specimen is serially sectioned and a touch prep is taken. Toto B1. C. LEFT AXILLARY SENTINEL LYMPH NODE #3 Received fresh are 2 tan pink lymph nodes 1.2 x 0.8 x 0.8cm and 1.9 x 1.5 x 0.8cm. The specimens are serially sectioned and 2 touch preps are taken. C1: 1 lymph node C2: 1 lymph node D. LEFT BREAST NEEDLE LOCALIZATION Received fresh labeled with matching patient identifiers and designated "wide local excision ieft breast" is a portion of resected breast tissue weighing 290 g and measuring 11 x 9 x 6 cm. The specimen is accompanied by a mammogram and needle localization wire. The specimen is received with orientation, the single short suture designates superior, long suture designates the lateral. The specimen is inked as follows: Anterior-blue, posterior-black, superior-red orange, medial-green,. Iateral-yellow. The specimen is serially sectioned from lateral to medial into 10 sections. Cut section. shows a firm beige ill-defined mass located 0.4-cm from the anterior/inferior margin. The mass measures 1.7 x 1.1 x 1 cm. the remainder of the specimen shows areas of white fibrous streaking septae adjacent to the lesion (medial aspect). The specimen was taken to mammography, sections were x-rayed. Representative sections are submitted as follows: D1: Perpendicular sections lateral margin (section 1) D2: Anterior, demonstrates metaltic clip (section 4) D3-D4: Anterior, dense tissue (section 4) D5: Inferior, dense tissue (section 4) D6-D9: Mass, anterior/inferior margin (section 5) D10-D12: Anterior/inferior (section 6) D13-D15: Anterior/superior (section 7) D16-D17: Anterior/posterior (section 8) D18-D19: Anterior/inferior (section 9) D20-D21: Perpendicular sections medial margin (section 10) E. ADDITIONAL RETROAREOLAR TISSUE LEFT BREAST Blue-Anterior portion Received in formalin is an oriented tan pink fragment of fibrofatty tissue 1.0 x 0.8 x 0.5cm. The anterior. portion is inked Blue and the specimen is trisected. Toto E1. F. LEFT AXILLARY NON SENTINEL LYMPH NODES Received in formalin are multiple tan pink soft tissue fragments aggregating to 5.0 x 3.0 x 2.0cm. Dissection reveals 1 fatty lymph node 2.2 x 2.0 x 1.4cm. F1-F2: 1 lymph node F3: remainder of specimen
+
+--- Page 2 ---
+Tss: DIAGNOSIS: A. LYmPH NODE, SENTINEL #1, LEFT AXILLARY, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1) - AE 1/3 NEGATIVE. B. LYMPH NODE, SENTINEL #2, LEFT AXiLLARY, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1) - AE 1/3 NEGATIVE. C. LYMPH NODE, SENTINEL #3 AND #4, LEFT AXILLARY, BIOPSY: - TWO LYMPH NODES, NEGATIVE FOR METASTASES (0/2) - AE 1/3 NEGATIVE - S100 MARKS CAPSULAR NEVUS. D. BREAST, LEFT, WIDE LOCAL EXCISION: - INVASIVE, LOBULAR CARCINQMA, SBR GRADE 2, MEASURING 2.1-CM - INVASIVE TUMOR PRESENT AT THE ANTERIOR SURGICAL RESECTION MARGIN - PLEOMORPHIC LOBULAR CARCINOMA iN SITU - SEE SYNOPTIC REPORT AND SEE NOTE. E. BREAST, ADDITIONAL RETROAREOLAR TISSUE, BiOPSY: - INVASIVE LOBULAR CARCINOMA PRESENT AT INKED SURGICAL RESECTION MARGIN, SEE NOTE. F. LYMPH NODE, LEFT AXILLARY, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (O/1). NOTE: The specimen was serially sectioned and x-rayed. The main mass was identified in slice #5. In slices #6 and 7, suspicious density is identified. This corresponds to the extending density seen on the mammogram. The main mass and the extending density microscopically are invasive iobular carcinoma. Also identified is metallic clip (area submitted in #D2). This are shows focus of LCIS. The largest invasive tumor measured on the slide (2.1-cm). The tumor is present at the anterior surgical resection margin (slide #D7) at a distance of 7-mm. The additional retroareolar tissue (part E.) also shows invasive tumor, presents at the anterior marked margin at a distance of 2-mm. Breast biomarkers pending and addendum report to follow. SYNOPTIC REPORT - BREAST Specimen Type: Excision Needle Localization: Yes - For mass Laterality:  Left Invasive Tumor: Present Multifocality: No WHO CLASSIFICATION Invasive iobular carcinoma 8520/3 Tumor size: 2.1cm Tumor Site:Not specified Margins: Involved at anterior Extent:: see note Tubular Score: 3 Nuclear Grade:. 2 Mitotic Score: Modified Scarff Bloom Richardson Grade:. 2 Necrosis: Absent
+
+--- Page 3 ---
+TSS: Vascular/Lymphatic Invasion:  None identified Lobular neoplasia:. LCIS Lymph nodes: Sentinel lymph node only Lymph node status:. Negative 0/5 DCIS not present ER/PR/HER2 Resuits ER: Pending PR: Pending HER2: Pending Pathological staging (pTN): pT 2 N 0 CLINICAL HISTORY: 46 year old with Left Breast Cancer PRE-OPERATIVE DiAGNOSIS: Left Breast Cancera INTRAOPERATIVE CONSULTATION: TPA-TPB: Negative for tumor. Diagnosis called to Dr at (A) and (B) by Dr. TPC1-TPC2: Atypical (both lymph nodes). Diagnosis called to Dr. at. by Dr. ADDENDUM: E-cadherin is negative compatible with lobular carcinoma phenotype.. SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimen: Surgical Excision Block Number: D7 ER: Positive Allred Score: 8 = Proportion Score 5 + Intensity Score 3 PR: Positive Allred Score:  5 = Proportion Score 2 + Intensity Score 3 COMMENT: The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring. range from 0 to 8. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2. METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Immunohistochemistry was performed using the mouse anti-human ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) provided by Dako (Dako, Carpenteria, CA) following the manufacturer s instructions. This assay was not modified. Interpretation of the ER/PR immunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by interna! review of staining performance. SYNOPTIC REPORT - BREAST HER-2 RESULTS Specimen: Surgical Excision Block Number: D7 Interpretation: NEGATIVE Intensity: 0 % Tumor Staining: 0%
+
+--- Page 4 ---
+TSS. Fish Ordered: No METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Her2 analysis was performed using the FDA approved Dako HercepTest (TM) test kit (. sing rabbit anti-human HER2. This assay was not modified. External kit-slides.  proviaea oy tne manufacturer (cell lines with high, low and negative HER2 protein expression) and in- house known HER2 amplified control tissue were evaluated along with the test tissue. Adequate, well preserved, clear-cut invasive carcinoma was identified for HER2 evaluation. Interpretation of the HER2 immunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal review of staining performance.. This assay has been validated according to the. ' joint recommendations and guidelines from. ASCO and CAP and from the NCCN HER2 testing in Breast Cancer Task Force. The Pathology Department takes full responsibility for this test's performance.. ONCOTYPE DX BREAST CANCER ASSAY RESULTS: Recurrence Score: 29 29 in the clinical validation study CLiNICAL EXPERIENCE: Patients with a recurrence score of: had an average rate of Distant Recurrence at 10 years of 19% ER Score: 7.2  Positive PR Score: 5.8  Positive Her2 Score: 7.6  Negative Interpretation: Negative < 6.5 Positive >= 6.5 ER  Negative < 5.5 Positive >= 5.5 PR. Her2 Negative <10.7 Positive >=11.5 Equivocal = 10.7 - 11.4 See separate report for further information. Test performed at: Gross Dictation: Pathologist, Microscopic/Diagnostic Dictation: Pathologist, '. Final Review: Pathologist, Final Review: Pathologist. Final: Pathologist, Addendum: Pathologist,. Addendum Final: Patholnnist Addendum: Pathologist, Addendum Final: Pathologis:
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diff --git a/output/text/272f1738-cc3d-4ddd-8e71-a74f7ddcd25f.txt b/output/text/272f1738-cc3d-4ddd-8e71-a74f7ddcd25f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8dd4faaca5342924d412c16ba842a851061d0d97
--- /dev/null
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+
+--- Page 1 ---
+TCGA-B9-4117 SURGICAL PATHOLOGY Surgical Pathology Report Accession #: Diagnosis: A: Fat,hilar,Nos, removal -No tumor seen. B: Kidney, left,hand assisted laparoscopic nephrectomy Histologic tumor type/subtype: papillary renal cell carcinoma,type2 Histologic grade: Fuhrman nuclear grade 3 Tumor size (greatest dimension) 84 cm Extent of tumorinvasion: Capsular invasion/perirenal adipose tissue: negative Gerota's fascia: negative Renal vein: negative Ureter: negative Venous (large vessel): negative Lymphatic small vessel):negative Adjacent organs: not applicable Histologic assessment of surgical margins: Perirenal adipose tissue: negative Gerotas fascia: negative Renal vein: negative Renal artery: negative Ureter: negative Adrenal gland: not submitted
+
+--- Page 2 ---
+Lymph nodes: none identified AJCC StagingpT2 pNx pMx This staging information is based on information available at the time of this report, and is subject to change pending clinical review and additional information. Clinical History: with clinical diagnosis of left renal mass. Gross Description: Received are two appropriately labeled containers. Container A is additionally labeled "hilar fat." It holds a 4.8x2.0x1.6 cm somewhatdisruptedfragment of red/yellow lobulated fibroadipose tissue. The fragment is palpated and no lymph node candidates are readily identified. The fat is serially sectioned and entirely submitted in blocks Al-A4, Container B: Specimen fixation: formalin Type of specimen: hand assisted laparoscopic nephrectomy Side of specimenleft Size andweight of specimen: 550 grams18x 11 x7.5 cm nephrectomy specimen (kidney and fat); the kidney is approximately13.8x7.5x7.5 cm Orientation: The specimen is received previously incised by the surgeon. The perinephric fat is markedly disrupted. The entire length of the kidney is received opened exposing the tumor.Margin evaluation will be difficult given the disrupted nature of this specimen. The kidney capsule in the area of the previous incision is inked blue. Presence/absence of adrenal gland: Absent; the superior perinephric fat is disrupted along with the vast majority of the remaining perinephric fat
+
+--- Page 3 ---
+Tumor description/site: Tumor is a mid kidney anterior cortical lesion with a solid, somewhat soft yellow diffusely brown and hemorrhagic cut surface. A portion of the tumor is missing as is adjacent normal kidney. These are presumed to be taken Tumorsize:8.4x7.3x6.0 cm Presence/absence of multicentricity: absent Confinement/non-confinement to the kidney: The tumor is abutting the overlying blue inked capsule. Given the perinephric fat is not disrupted, it is believed to be not attached. Exact determination of confinement cannot be determined. Extent of invasion: Perirenal adipose tissue: cannot determine Gerota'sfascia: absent Renal vein: tumor does not involve Ureter: tumor does not involve Other organs: n/a Surgical margins: Perirenal adipose tissue: cannot determine Renal vein: negative Renal artery: negative Ureter: negative Description of kidney away from tumor: The remainder of the kidney consists of dark red/brown renal parenchyma with a distinct corticomedullary junction. The cortexis approximately1 cm and the medulla is up to 1.8 cm. There is no evidence of papillary necrosis. The renal pelvis is unremarkable. Lymph nodes (hilar): There is scant hilar adipose tissue present. No hilar lymph node candidates are identified. Hilar fat was submitted as specimen A. Other significant findings: none Tissue submitted for special investigations: Tumor was taken by Tissue Procurement. Digital photograph taken: no
+
+--- Page 4 ---
+Block summary: B1 - ureteral and hilar vascular margins, en face B2- tumor overlying blue inked capsule and adjacent normal kidney B3-tumor B4 - tumor and adjacent renal sinus B5- additional tumor and adjacent kidney B6-normal kidney B7-B8 - disrupted perirenal fat from the approximate area of the tumor
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diff --git a/output/text/274f6c8c-8905-4c1d-848d-2f82f681c540.txt b/output/text/274f6c8c-8905-4c1d-848d-2f82f681c540.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d7e9f8bcab38a1699974ad2c7722131a4ed04189
--- /dev/null
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+
+--- Page 1 ---
+UUID:0A596611-ED33-4CC5-9C27-D2F1C5E0E6AF TCGA-UZ-A9PP-01A-PR Redacted SURGICAL PATHOLOGY REPORT Patient Name Accession #: Med. Rec.#: Visit #: Service Date. DOB: Sex: Male Received: Soc. Sec. #: Locationt Client: Physician(s): FInal Pathologic Diagnosis. A. Perinephric fat, excision: Fibroadipose tissue, no tumor seen. B. Superior margin, excision: Fibroadipose tissue, no tumor seen. C. Base margin, excision: No tumor seen.. D. Right renal mass, excision: Papillary renal cell carcinoma (chromophil), 3.5cm diameter, Fuhrman nuclear grade 2, excised. ICD-b-3 E. Perinephric fat, excision: No tumor identified. arsynsm,gotpillerey rerral ceSl'CCJonphil) 8Q4O/e Comment: Kidney Tumor Synoptic Comment Site;Kwluy NoS C64.9 -Histologic type: Renal cell carcinoma, papillary (chromophil) type. Qt J 3+30|14 -Grade: 2 -Maximum tumor diameter: 3.5 cm. -Capsule/perirenal fat: Tumor does not penetrate the capsule which surrounds the tumor completely; only part of this capsuie is surrounded by fat or renal tissue. -Hilar lymph nodes (number positive/number of nodes): None submitted or found. -Resection margins: Superior margin" and "Base margin" are negative for tumor. -Stage: pTlaNxMx. Page 1 of 2
+
+--- Page 2 ---
+Specimen(s) Receivedd A:Perinephric fat. B:Superior margin (FS). C:Base margin (FS). D:Right renal mass E:Perinephric fat Intraoperative Diagnosis FS1 (B1) "Soft tissue," superior margin, biopsy: Fibroadipose tissue, no tumor. FS2 (C1) *Kidney,* Base margin, biopsy: Renal parenchyma, no tumor.. Clinical History. The patient is a car-old man with a right renal mass, who undergoes resection. Gross Description The specimen is received in five parts, each labeled with the patient's name and medical record number. Parts A-D are received fresh. Part E is received in formalin. Part A, additionally labeled *1 - perinephric fat," consists of fatty tissue measuring 1.9 x 1.5 x 1.0 cm as a pile. The specimen is entirely submitted in cassette A1.. Part B, additionally labeled *2 - superior margin," consists of fibrofatty tissue with no visible soft tissue. measuring 2.5 x 0.8 x 0.5 cm. The entire specimen is frozen for frozen section 1, with the remnant submitted in cassette B1.. Part C, additionally labeled "3 - base margin (FS)," consists of a single segment of normal-appearing kidney measuring 3.0 x 2.0 x 1.0 cm; it corresponds to a puncture of the renal mass capsule (specimen D). The deep margin is inked blue by the surgeon; it is re-inked black and then entirely submitted for frozen sections 2 and 3 and the tissue blocks are subsequently entirely submitted in cassettes C1-C2.. Part D, additionally labeled "right renal mass," consists of a 3.5 x 2.5 x 2.0 cm nodule that is inked on 50% of the surface. There is attached fat, measuring 4.0 x 3.5 x 2.0 cm as a pile. The noduie is incised to reveal a brown-tan, soft mass that appears to be necrotic. Attached to the nodule is a rim of brown tissue measuring 3.5 x 1.5 x 0.7 cm. Representative sections of the nodule and the attached brown tissue are submitted in cassettes D1-D4. The fatty tissue is thoroughly evaluated for candidate lymph nodes and candidate lymph nodes are submitted in cassette D5. Representative sections of the fat are submitted in cassette D6. Part E, additionally labeled "5 - perinephric fat," consists of multiple yellow, glistening, irregular, unoriented adipose tissue fragments measuring 14.0 x 8.0 x 2.5 cm in aggregate. Upon sectioning, the specimen consists of grossly normal-appearing adipose tissue without areas of thickening. Representative sections are submitted in cassettes E1-E3. Diagnosis based on gross and microscopic examinations. Final diagnosis made by attending pathologist following review of all pathology slides.. Pathology Resident athologist Electronically signed out on 1/4/14 Page 2 of 2
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diff --git a/output/text/275fb41b-acc5-4bad-90e5-29edff0a9fec.txt b/output/text/275fb41b-acc5-4bad-90e5-29edff0a9fec.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6e6ab7705649f2d1ffae3e565f4057a8e9626a14
--- /dev/null
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+
+--- Page 1 ---
+UUID:8A19AA55-981F-4325-B730-068F928F1C13 TCGA-OL-A66K-01A-PR Redacted Sample # IcD-o-3 8s20T3 Sitc B YBuss+n1ss cso9 S/16/139J FINAL PATHOLOGIC DIAGNOSIS A. Right axillary sentinel node #1: - One lymph node, negative for metastatic carcinoma (0/1)(HE and CKAE1/AE3) B. Right axillary sentinel node #2: - One lymph node, negative for metastatic carcinoma (0/1)(HE and CKAE1/AE3) C. Right breast, simple mastectomy: - Invasive lobular carcinoma, SBR grade Il, multicentric, see breast pathologic parameters. - Lobular carcinoma in situ and atypical lobular hyperplasia. - Margins of resection are negative, distance to the closest margin (anterior-inferior) is > 1.5 mm for invasive carcinoma, see comment. - Previous biopsy sites identified. - Intraductal hyperplasia, usual type. - Ectatic ducts.. - Apocrine metaplasia.. - Nipple focally involved by LCIS. - Skin with scar, negative for malignancy, see comment.
+
+--- Page 2 ---
+D.Skin; lateral corner, excision: - Skin and subcutaneous tissue, no evidence of malignancy Breast Pathologic Parameters 1. Invasive carcinoma: Three mass lesions:. A.Gross measurement: a9:30 to 10:30 position:4.4 cm b8:30 position:2 cm C)4:00 position: 1 cm B.Composite histologic (modified SBR) grade:I - Architecture: 3 - Nuclear grade: 2 - Mitotic count: 1 C.Associated intraductal carcinoma in situ (LCiS) -Within main masses (forming 10 % of tumor volume) -Extending away from main masses 2. Excisional biopsy margins: Free of tumor - Invasive carcinoma > 1.5 mm from anterior-inferior (closest) margin (lesion C) - Additional margins from lesions A and B are > 2 mm away. 3.Blood vessel and lymphatic invasion: Highly suspicious in breast parenchyma
+
+--- Page 3 ---
+4. Nipple:focally involved by LCIS 5.Skin: uninvolved 6.Skeletal muscle: absent 7.Axillary lymph nodes: Negative (0/2) 9.Special studies (see outside case biopsy of upper outer and lower inner quadrant): - ER: Moderate in > 75% of invasive tumor nuclei PR: Strong expression in > 90 % of invasive tumor nuclei -Her2/neu antigen (IHC): 2+, equivocal -Her2/neu antigen (FISH): pending on block C7 (9:30 to 10:30 position) 10.pTNMAJCC,7th edition2010pT2m),NosnMX Effective this Checklist utilizes the 7th edition TNM staging system for breast of the American Joint Committee on Cancer (AJcC) and the International Union Against Cancer (UicC)
+
+--- Page 4 ---
+Clinical History: The patient is a year old female with a history of invasive lobular carcinoma grade 2 of 3 and lobular carcinoma in-situ of the right breast. She undergoes right simple mastectomy and sentinel lymph node biopsy Comment C. CKAE1/AE3 is negative in the skin section with scar. Myosin heavy chain performed on C12 reveals absence of a myoepithelial cell layer supporting invasive carcinoma. Specimens Received: A: Right axillary sentinel node #1 B: Right axillary sentinel node C: Right breast D: Skin; biopsy Gross Description: Received are four containers, each labeled with the patient's name and medical record number.
+
+--- Page 5 ---
+A. Container A is further designated 1. Right axillary sentinel node #1. Received fresh for frozen section diagnosis is a 3 x 1.5 x 1 cm lymph node which is bisected and entirely frozen. Frozen section diagnosis is'one lymph node negative for tumor by Dr. The frozen section remnant is submitted entirely in cassettes A1-A2FS B. Container B is further designated '2. Right axillary sentinel node #2. Received fresh and placed in formalin is a 0.9 x 0.8 x 0.4 cm blue lymph node which is submitted entirely incassette B1 C. Container C is further designated '3. Right breast, double short stitch. superior, double long stitch lateral.' Received fresh is a 1,259 gm mastectomy specimen measuring 30 cm from medial to lateral, 21 cm from superior to. inferior, and 8 cm from anterior to posterior. There is a short stitch marking the superior edge and a long stitch marking the lateral edge.There is a 25.5 x 14.5 cm ellipse of pink-tan skin with a 4.1 cm areola and a 1.1 cm nipple. The anterior-superior margin is inked in blue, the anterior-inferior margin is inked in green, and the posterior/deep margin is inked in black. The specimen is then sliced into 16 slices with slice #1 being the most lateral slice. In slices 9-10 at the 9:30 to 10:30 position is a main mass measuring 4.4 x 4 x 2.6 cm. The mass extends to 2 cm from the inked, black margin.In addition at the 8:30 position in slices 7-8 there is a 2 x 1.5 x 1 cm mass which is 6 cm from the. inked, black margin and 0.4 from the inked green margin. In slice 15 at the 4 o'clock position there is a 1 x 1 x 0.5 cm firm, white nodule which is 0.5 cm
+
+--- Page 6 ---
+from the inked, green margin and 3 cm from the inked, black margin.The nipple. is amputated, bisected and submitted entirely in cassette C1. the skin surrounding the tissue just deep to the nipple are submitted in cassette C2. At 6 cm lateral to the nipple is a 0.5 x 0.3 cm slightly raised area of skin which is the same, pink-tan color as the surrounding skin. This is submitted in cassette C3. Representative sections are submitted as follows: C4: lesion from slice 7. C5:lesion from slice 8 C6-C7: mass from slice 9 with the black ink in C6 C8: additional representative section of mass from slice 9 C9-10: mass from slice 10 with the inked blue margin in C9 (grossly tumor is only in C10) C11: scar like area from slice 15 C12: scar like area from slice 15 In the superior area of slices 13-14 is a 3 x 2 x 2 cm vaguely nodular area dense, white-tan parenchyma. This area is 1.5 cm from the inked, blue margin. and 3 cm from the black margin C13: vaguely nodular area from slice 13 C14:vaguely nodular area from slice 14 C15: representative section from the upper-outer quadrant from slice 3 C16: representative section from the lower-outer quadrant from slice 5. C17: representative slice from the upper-inner quadrant from slice 16
+
+--- Page 7 ---
+C18: representative section from lower-inner quadrant from slice 14. D. Container D is further designated '4. Skin; biopsy.' Received fresh and placed in formalin is a 14 gram, 4 x 2.5 cm ellipse of pink-tan skin with a central 1.9 x 0.9 cm defect. It is excised to a depth of 1 cm. The deep margin is inked black. The circumferential margin is inked blue. The specimen is. serially sectioned to reveal yellow, lobular unremarkable subcutaneous adipose. tissue. Representative sections are submitted in cassettes D1-D2. V.D. Pathologist Sign Out: /
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diff --git a/output/text/2762308c-4148-42cc-96a3-8f4f22d1f607.txt b/output/text/2762308c-4148-42cc-96a3-8f4f22d1f607.txt
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index 0000000000000000000000000000000000000000..f73504a42e5e7bab2a59af3bd27d915bbea98ae0
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+page 1 / 2 Department of Cancer Pathology copy No. Date: Examination: Intraoperative examination Internal invoice No. Cost of diagnostic procedure  Examination No.: Patient: xxx PESEL: XXX Age: Gender: F Material: Lesion resection - from the Ieft breast with -- outer qjuad. boundary Ics-0-3 Unit in charge: Cautinoma, mfiYtnatng ouet;no5 850of3 Physician in charge: Srte: srast,N0s C50.9 Material collected on: ' Material received on: Expected time of examination: 20 minutes (from receipt of the material) Clinical diagnosis: Cancer of the left breasty'Cancer of the left breast. Lesion on the boundary of outer quadrants. Marked typically. Please evaluate the margins. Examination performed on: Results of immunohistochemical examination: Part of the breast sized 9 x 7 x 4 cm with a skin flap of 5 x 1.5 cm. Margins: 1.3 cm to the base, 1.6 cm to the skin, 2.5 cm to the sternum, 2.5 cm to the axilla, 3 cm to the shoulder, 2 cm to the lower boundary Result of intraoperative examination: Carcinoma invasivum Compliance validated by:' Examination performed on: Macroscopic description: Part of the breast sized 9 x 7 x 4 cm with a skin flap of 5 x 1.5 cm. Margins: 1.3 cm to the base, 1.6 cm to the skin, 2.5 cm to the Sternum, 2.5 cm to the axilla, 3 cm to the shoulder, 2 cm to the lower boundary. Microscopic description: Carcinoma ductale invasivum - NHG2 (3+2+1/5 mitoses/10 HPF - visual area 0.55mm). Additionally, benign lesions of the type adenosis sclerosans et "blunt duet" and lymph node free of neoplastic metastasis. Margins as in the macroscopic description. Histopathological diagnosis: Carcinoma ductale invasivum mammae sinistrae. (NHG2, pTIc, pNO /sn/) Invasive ductal carcinoma of the left breast. (NHG2, pTIc, pNO /sn/) Compliance validated by: Examination performed on: UUID:9320030D-5E19-4BEE-99DA-36686762DED1 TCGA-D8-A1XA-01A-PR Redacted nous Pril
+
+--- Page 2 ---
+page 2 / 2 Examination: Intraoperative examination Examination No.: Patient: xxx PESEL: XXX Gender: F Examination performed on: Result of immunohistochemical test: Estrogen receptors found in over 75% of neoplastic cell nuctei. Progesterone receptors found in over 75% of  neoplastic cell nuclei. HER2 protein stained with HercepTestM by DAKO. Negative reaction in invasive carcinoma cells ( Score = 1+ 1 Compliance validated by: CONTACT YOUR DOCTOR WITH THIS REPORT!
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diff --git a/output/text/276a4575-2ace-405c-8922-87531a319680.txt b/output/text/276a4575-2ace-405c-8922-87531a319680.txt
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index 0000000000000000000000000000000000000000..a410c9963a1be93a24d667393fac0b40a6497f18
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+Page 1 of 5 TCGA-B6-A400-01A-PR Redacted Patlent:  AP Surgical Pathology: Corrected Surg Path CLINICAL HISTORY: Not provided. GROSS EXAMINATION: A. "Left axilla non-sentinel node (AFl)". Received fresh for frozen section is. a 1.8 x 1 x 0.6 cm tan-yellow lymph node candidate which is bisected and frozen as AFl, the frozen section remnant is submitted in block Al. B. "Left sentinel node number one (BFi)". Received fresh for frozen section are three tan-yellow lymph node candidates. The larger lymph node candidate 2 x 1.2 x 1 cm) is bisected and frozen as BFl, and frozen section remnant is submitted in block Bl. The remaining two lymph node candidates (0.5 x 0.5 x 0.3 cm and 1 x 0.7 x 0.4 cm lymph node candidate) are submitted in toto as frozen section BF2, and the frozen remnant is submitted in block B2. C. "Left sentinel node number two (cr1)". Received fresh for frozen section is a 3 x 2.5 x 0.8 cm fragment of tan-yellow fibrofatty tissue. One lymph node candidate is identified (1.9 x 1 x 0.7 cm) which is bisected and frozen as CF1. The frozen section remnant is submitted in block cl. D. "Left breast cancer, 1:oo", received fresh and placed in formalin: Procedure: Wire guided partial mastectomy Specimen orientation: Suture: long-lateral, short-superior. Clips: two clips medial, one clip-inferior. Specimen dimensions: Medial to Lateral: 8.5 cm 1cd-o3 Anterior to Posterior:  2.5 cm. Ca^Cinomq,inF JHahnq ducta|NOS Superior to Inferior: 9.5 cm Skin dimensions: 4.3 x 1.3 cm with a 0.4 cm long scar. 8s0 f3 Sik: breast, Nos ct Margins inked: Superior: Red c50.9 Inferior: Yellow 7-Z-12 Anterior: Blue Ro Posterior: Black Sectioned: Medial to lateral Gross findings: There is a tan-white indurated ill defined area with peripheral hemorrhage and fat necrosis. Lateral and superior to this area is a. second focus of white-tan induration with adjacent thick white-tan fibrous tissue. The remaining parenchyma is tan-yellow lobulated adipose tissue. **************+*************************#***+*+++**+***+******* Gross tumor size: 2.3 x 2.1 x 1.2 cm Multifocal tumor: Additional lesion is 1.2 x 0.8 x 0.5 cm which directly abuts. the primary focus. Distance of tumor from gross surgical margin for the primary tumor: Superior: 2.1 cm Inferior: 3.2 cm Anterior: 0.6 cm Posterior: 1.2 cm Medial: 4.2 cm Lateral: 1 cm Additional lesion: Superior: 3.1 cm Inferior: 2 cm
+
+--- Page 2 ---
+Page 2 of 5 Anterior: 1 cm Posterior: 1 cm Medial: 6.9 cm Lateral: 0.5 cm Sectioned specimen radiographed?. Yes Radiograph findings: Mass: Yes Microcalcifications: Yes Biopsy site microclip: No Specimen photograph? Yes Block diagram? Yes Sections submitted from medial to lateral in blocks D1 through D35 Specimen completely submitted? No. BLOCK SUMMARY: Medial margin-D1. Lateral margin-D34 and D35. Inferior margin: D13 Superior margin: D19 Anterior and posterior margins: D23 Primary tumor: D10, D11, D15, D16, D17, D18, D21, D22, D23, D24, D25, D27, D28, D31, D33. Secondary lesion: D25, D27, D28, D31, D32, D33 Microcalcifications: D12, D15, D16, D17, D18, D20, D23, D25, D33. E. "Left axillary mass, long stitch-lateral, short-superior", received fresh and placed in formalin: Procedure: wire guided partial mastectomy. Specimen orientation: Long stitch lateral, short stitch superior. Specimen dimensions: Medial to Lateral: 5.6 cm Anterior to Posterior: 1 cm. Superior to Inferior: 3.6 cm Margins inked: Superior: Red Inferior: Yellow Anterior:  Blue Posterior: Black Sectioned: Medial to lateral Gross findings: A well circumscribed white-brown nodule with an embedded microclip in the medial portion. Lateral to this first nodule is a second ill defined firm nodule. The remaining parenchyma is yellow-tan lobulated adipose tissue. Gross tumor size:1.6 x 0.6 x 0.5 cm. Multifocal tumor: Second lesion is 1.2 x 0.5 x 0.4 cm, and it is 0.7 cm from the first. Distance of tumor from gross surgical margin: First nodule: Superior: 1.8 cm Inferior:0.6 cm Anterior: 0.2 cm Posterior: 0.2 cm Medial: 2 cm
+
+--- Page 3 ---
+Page 3 of 5 Lateral: 3.6 cm Second nodule: Superior: 1.7 cm Inferior: 1 cm Anterior: 0.2 cm Posterior 0.3 cm Medial: 5.9 cm Lateral: 1.8 cm Sectioned specimen radiographed? Yes Radiograph findings: Mass: Yes Microcalcifications: Yes Biopsy site microclip: Yes. Specimen photograph? Yes. Block diagram? Yes Sections submitted from medial to lateral in blocks El through E21. Specimen completely submitted? Yes. BLOCK SUMMARY: Medial margin-E1 Lateral margin:E21 Anterior, posterior, inferior margins for first nodule-e8.. Anterior, posterior, superior, inferior margin for second nodule-e13. First nodule-E6, E7, E8, E9, E10, Ell. Second nodule:E13, E14, E15, E16 Microclip: E11 Microcalcifications: E8, E13, E19 F. "Left axillary contents". Received fresh and placed in formalin is a 6.5 x Fourteen lymph node candidates are identified ranging in size from 0.5 x 0.5 x 0.4 cm to 3.5 x 1.5 x 1.3 cm. The smallest lymph node candidate is submitted in blocks F1-F3, and the two largest lymph node candidates are inked blue and black, bisected and submitted in blocks F4-F6.. A. REPORT REVISED ON . INTRA OPERATIVE CONSULTATION: A. "Non-sentinel node right axilla": AFl- one lymph node candidate, bisected (1.3 x 1 x 0.6 cm)- no tumor is seen (Dr. B. "Sentinel node number one": BFl (one lymph node candidate, bisected, 2 x 1.6 x 1 cm) positive for metastatic cancer (micrometastases) (Dr. BF2 (two lymph node candidates, intact (0.5 x 0.5 x 0.3 cm) and 1 x 0.6 x 0.4 cm, no tumor is seen (Dr.. "Sentinel node number two": cF1- one lymph node candidate, bisected, 1.9 x 2 x 0.7 cm, positive for metastatic cancer (micrometastases) (Dr.. MICROSCOPIC EXAMINATION: Microscopic examination is performed. PATHOLOGIC STAGE: PRoceDure: Partial mastectomy, sentinel lymph node biopsy with completion axillary dissection. PATHOLOGIC STAGE (AJCC Edition): pT2 pN2a pMX NOTe: Information on pathology stage and the operative procedure is. transmitted to this Institution's Cancer Registry as required for. accreditation by the Commission on Cancer. Pathology stage is based solely
+
+--- Page 4 ---
+Page 4 of 5 upon the current tissue specimen being evaluated, and does not incorporate information on any specimens submitted separately to our Cytology section, past pathology information, imaging studies, or clinical or operative findings. Pathology stage is only a component to be considered in determining The exact operative procedure is available in the surgeon's operative report. **REVISED DIAGNOSIS**: A. "LEFT AXILLA, NON-SENTINEL LYMPH NODE" (BIOPSY): ONE LYMPH NODE, NO EVIDENCE OF MALIGNANCY (O/1). B. "LEFT AXILLA, SENTINEL LYMPH NODE # 1" (BIOPSY): METASTATIC ADENOCARCINOMA IN THREE LYMPH NODES (3/3). SIZE OF LARGEST METASTASIS: 6 MILLIMETERS. EXTRACAPSULAR INVASION: ABSENT. C. "LEFT AXILLA, SENTINEL LYMPH NODE # 2" (BIOPSY): METASTATIC ADENOCARCINOMA IN ONE LYMPH NODE (1/1). SIZE OF LARGEST METASTASIS: 4 MILLIMETERS. EXTRACAPSULAR INVASION: ABSENT. D. "LEFT BREAST CANCER, 1:OO" (WIRE GUIDED PARTIAL MASTECTOMY): INVASIVE ADENOCARCINOMA OF THE BREAST. HISTOLOGIC TYPE: DUCTAL. NOTTINGHAM COMBINED HISTOLOGIC GRADE: 3 OF 3. TUBULE FORMATION SCORE: 3 NUCLEAR PLEOMORPHISM SCORE: 3 MITOTIC RATE SCORE: 3 GROSS TUMOR SIZE: 2.3 X 2.1 X 1.2 CM. SIZE OF INVASIVE COMPONENT: 2.3 CM. LOCATION OF THE TUMOR: ADJACENT TO PREVIOUS BIOPSY SITE. LYMPHATIC/VASCULAR INVASION: PRESENT. MULTIFOCAL TUMOR: ABSENT (SECOND MASS LESION DESCRIBED GROSSLY IS FAT NECROSIS) . IN-SITU CARCINOMA: PRESENT. TYPE OF IN-SITU CARCINOMA: COMEDO. NUCLEAR GRADE OF IN-SITU CARCINOMA: 3 OF 3. NECROSIS: PRESENT. DCIS EXTENDING OUTSIDE INVASIVE TUMOR MASS: ABSENT. SIZE OF IN-SITU CARCINOMA: NOT APPLICABLE. SKIN STATUS: FREE OF TUMOR. STATUS OF NON-NEOPLASTIC BREAST TISSUE: NEEDLE CORE BIOPSY SITE, AND FAT NECROSIS. SURGICAL MARGIN STATUS: NEGATIVE (GREATER THAN 2 MM). ESTROGEN/PROGESTERONE RECEPTOR, CELL CYCLE, EGFR AND HER2/NEU ANALYSIS: PENDING, PARAFFIN BLOCK NUMBER D11. RESULTS WILL BE ISSUED SEPARATELY FROM THE IMAGE CYTOMETRY LAB. E. "LEFT AXILLARY MASS" (EXCISION) : METASTATIC ADENOCARCINOMA IN ONE OF FOUR AXILLARY LYMPH NODES (1/4). SIZE OF METASTASIS: 1.6 CM. EXTRACAPSULAR INVASION: PRESENT
+
+--- Page 5 ---
+Page 5 of 5 CHANGES CONSISTENT WITH A NEEDLE CORE BIOPSY SITE ARE PRESENT. MARGIN STATUS: NEGATIVE. F. "LEFT AXILLARY CONTENTS" (COMPLETION NODE DISSECTION): METASTATIC ADENOCARCINOMA IN ONE OF TWENTY LYMPH NODES (1/20). SIZE OF METASTASIS: O.5 MILLIMETERS. EXTRACAPSULAR INVASION: ABSENT. COMMENT: This report revised to correct the site for specimens A-C, which were received labelled as "right". Per the correct site is left. "is notified of this revision. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es). Electronically signed: DIAGNOSIS: ****SEE REVISED REPORT**** REPORT REVISED ON I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es). Electronically signed: CI ADDENDUM 1: Please see for results of supplementary tests. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es). Electronically signed. Performed by: Ordering MD:
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index 0000000000000000000000000000000000000000..4da67b694e5a01c7b31998ffa4f8550f2c492740
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+/cs-0-3 Cacnoma,mfi(frafxg lobule) 8520/3 SPECIMENS: A. SLN #1 RIGHT AXILLA CQcF Sit: buuf,n1s c5o9 B. RIGHT BREAST His/ C. RIGHT BREAST UPPER OUTER QUADRANTE D. RIGHT BREAST LATERAL FLAP E. LEFT BREAST AND AXILLARY TAIL F. ADDITIONAL AXILLARY CONTENTS SPECIMEN(S): UUID:08A790DE-B01D-4140-B81C-B4844291D71E0 A. SLN #1 RIGHT AXILLA  TcgA-e2-A1Lg-01a-pR Redacted B. RIGHT BREAST C. RIGHT BREAST UPPER OUTER QUADRANT D. RIGHT BREAST LATERAL FLAP E. LEFT BREAST AND AXILLARY TAIL F. ADDITIONAL AXILLARY CONTENTS GROSS DESCRIPTION: A. SLN #1 RIGHT AXILLA Received fresh labeled with the patient's identification and "SLN #1 right axilla" is a piece of fibroadipose tissue, 4.5 x 3.1 x 1 cm. It is searched for lymph nodes. Four lymph nodes are identified measuring 2.5 x 1.1 x 0 .6 cm, 1.5 x 1.1 x 1 cm, 0.6 x 0.4 x 0 .2 cm, and 0.6 x 0.5 x 0.2 cm. The 3 smaller lymph nodes are inked orange, green, and black; the lymph nodes are bisected and half of each is submitted for frozen section diagnosis. Lymph nodes are submitted entirely: FSA1: frozen section of 2 lymph nodes, bisected (1/2 of each) FSA2: frozen section of 2 lymph nodes, bisected (1/2 of each) A3: remainder of lymph nodes from FSA1 A4: remainder of lymph nodes from FSA2 B. RIGHT BREAST  Received fresh labeled with the patient's identification and "right breast" is an oriented 1697g, 38 x 30 x 3cm simple mastectomy with 23 x 20cm tan-brown skin ellipse and 1.3cm everted nipple. Ink code: anterior-superior: blue, anterior-inferior: orange, posterior-black. The specimen is serially sectioned into 19 slices from lateral to medial with nipple in slice 10 revealing a 4cm area of scar tissue, with a 1cm central previous biopsy site, 4.6cm from the deep margin in the UIQ of slice 12. The specimen is radiographed and 3 biopsy clips are identified (in the UC of slice 10, and two in the UIQ of slice 12), 1.5cm from the closest anterior-superior margin in the UIQ of slice 12. A second possible 1 x 0.9 x 0.7cm previous biopsy site is identified in 3.8cm from the deep margin in the UOQ of slice 7. Representatively submitted: B1: nipple slice 10 B2: UOQ slice 5 B3: UOQ slice 6 B4: UOQ previous bx site UOQ slice 7 B5: LOQ slice 7 B6: UOQ slice 8 B7: LOQ slice 8 B8: UOQ slice 8 B9: UOQ slice 9 B10: LOQ slice 9 B11-B14: UC with clip ID in B13 slice 10 B15: deep margin and skin UC slice 10 B16: LC slice 10 B17-B18: UIQ slice 11 B19: LIQ slice 11 B20: UIQ skin slice 12 B21-B23: UIQ with 2 bx clips slice 12 B24: LIQ slice 12 B25: UIQ slice 13 C. RIGHT BREAST UPPER OUTER QUADRANT Received fresh labeled with the patient's identification and *upper outer quadrant" is an oriented (suture at final anterior margin) 30 g, 11.3 x 3.7 x 0.9 cm fibrofatty tissue. Final margin is inked biack. Serial sectioning reveals no discrete lesions. Representatively submitted in cassette C1-C3. D. RIGHT BREAST LATERAL FLAP
+
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+Received fresh labeled with the patient's identification and "right breast lateral flap" is an oriented (suture at final anterior margin) 16 g, 6.6 x 3.9 x 1.2 cm fibrofatty tissue. Final margin is inked black. Serial sectioning reveals no discrete lesions. Representatively submitted in cassettes D1-D3. E. LEFT BREAST AND AXILLARY TAIL Received fresh labeled with the patient's identification and "left breast and axillary tail" is an oriented. 1844g, 30 x 27 x 5cm modified radical mastectomy with 25 x 21cm tan-brown skin ellipse and 1.5cm everted nipple. Ink code: anterior-superior: blue, anterior-inferior: orange, posterior-black. The specimen. is serially sectioned into 13 slices from medial to lateral with nipple in slices 5-9 revealing a 4 x 3 x 2.8cm tan-white firm well-circumscribed mass in the UOQ of slices 9-10, 3cm from the deep margin. A dense firm ill-defined fibrous area 2cm in greatest dimension is identified in the UC of slice 6, 2.5cm from the closest posterior margin. The axillary tail is 11 x 10 x 4cm. Dissection reveals 18 lymph nodes ranging from 0.2 x 0.2 x 0.2cm to 1.4 x 1 x 1cm. A portion of the specimen is submitted for tissue procurement. Representatively submitted:. E1: nipple slice 5 E2: nipple slice 6 E3: LIQ slice 3 E4: UIQ slice 4 E5: UC slice 5 E6: LC slice 5 E7-E8: nodular area UC slice 6 E9: LC slice 6 E10-E11: UOQ slice 7 E12: LOQ slice 7 E13: UOQ slice 8 E14-E16: mass UOQ slice 9 E17: skin and deep margin UOQ slice 9. E18: LOQ slice 9 E19: mass UOQ slice 10 E20: LOQ E21: 5 lymph nodes E22: 5 lymph nodes E23: 3 lymph nodes E24: 2 lymph nodes E25: 1 lymph node E26: 1 lymph node E27: 1 lymph node HW F. ADDITIONAL AXILLARY CONTENTS Received fresh labeled with the patient's identification and "additional axillary contents" are pieces of yellow-tan fat in aggregate, 3.6 x 2.8 x 0.6 cm; containing a lymph node, 0.8 x 0.6 x 0.2 cm. Submitted entirely: F1: 1 lymph node F2-F3: remainder of soft tissue DIAGNOSIS: A. LYMPH NODE, SENTINEL #1, RIGHT AXILLA, EXCISION:E - TWO REACTIVE LYMPH NODES, NEGATIVE FOR METASTATIC CARCINOMA (0/2). B. BREAST, RIGHT, MASTECTOMY: - ADENOID CYSTIC CARCINOMA (3 CM AGGREGATE SIZE). - LOBULAR CARCINOMA- IN- SITU (LCIS), NUCLEAR GRADE 2. - RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA. - FIBROADENOMA (0.35 CM). METAPLASIA - SCLEROSING ADENOSIS, USUAL DUCTAL HYPERPLASIA, APOCRINE AND MICROCALCIFICATIONS. C. BREAST, RIGHT UPPER OUTER QUADRANT, EXCISION: - FATTY BREAST TISSUE, NO TUMOR IS SEEN. D. BREAST, RIGHT LATERAL FLAP, EXCISION: - FATTY BREAST TISSUE, NO TUMOR IS SEEN.
+
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+E. BREAST AND AXILLARY TAIL, LEFT, MASTECTOMY:E - INVASIVE LOBULAR CARCINOMA, MAINLY PLEOMORPHIC TYPE,E SBR GRADE 3, SOLID GROWTH PATTERN. - TUMOR MEASURES 4CM. - RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA. - RADIAL SCAR. - EIGHTEEN REACTIVE LYMPH NODES, NEGATIVE FOR METASTATIC CARCINOMA (O/18) F. LYMPH NODE, ADDITIONAL AXILLARY CONTENTS, EXCISION: - ONE REACTIVE LYMPH NODE, NEGATIVE FOR METASTATIC CARCINOMA (0/1). SYNOPTIC REPORT - BREAST Specimens Involved Specimens: A: SLN #1 RIGHT AXILLA B: RIGHT BREAST C: RIGHT BREAST UPPER OUTER QUADRANTE D: RIGHT BREAST LATERAL FLAP Specimen Type: Mastectomy Needle Localization:  No Laterality:Right Invasive Tumor: Present Multifocality: No WHO CLASSIFICATION Adenoid cystic carcinoma._8200/3 Tumor size: 3cm Tumor Site: Upper outer quadrant Margins: Negative Distance from closest margin: 3.8cm deep Necrosis: Absent Vascular/Lymphatic Invasion:Indeterminate Lobular neoplasia: LCIS Lymph nodes: Sentinel lymph node Lymph node status: Negative 0/ 2  Non-neoplastic areas: Fibroadenoma, extensive sclerosing adenosis, usual ductal hyperplasia, apocrine  metaplasia DCIS not present ER/PR/HER2 Results ER: Negative PR: Negative Performed on Case: Pathological staging (pTN): pT 2 N 0 Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition SyNOPTIC REPORT - BREAST Specimens Involved Specimens: E: LEFT BREAST AND AXILLARY TAIL F: ADDITIONAL AXILLARY CONTENTS Specimen Type: Mastectomy Needle Localization:  No Laterality: Left Invasive Tumor: Present Multifocality: No WHO CLASSIFICATION
+
+--- Page 4 ---
+TSS Invasive lobular carcinoma 8520/3 Tumor size. 4cm Tumor Site: Upper outer quadrant. Margins: Negative Distance from closest margin:  3cm deep Tubular Score: 3 Nuclear Grade: 3 Mitotic Score: 3 Modified Scarff Bloom Richardson Grade: 3 Necrosis: Present Vascular/Lymphatic Invasion: Indeterminate Lobular neoplasia: LCIS Lymph nodes: Axillary dissection Lymph node status: Negative 0/ 19  Non-neoplastic areas: Sclerosing adenosis, usual ductal hyperplasia, fibroadenomatoid changes, radia! scar DCIS not present ER/PR/HER2 Results ER: Negative PR: Negative HER2: Negative by FISH Performed on Case: Pathological staging (pTN): pT 2 N 0 Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition. CLINICAL HISTORY: year African American with history of ADH and LCIS with radial scar of right breast. WLE done 4- Was followed with imaging and. : was found to have right adenocystic carcinoma and ILC. On left. PRE-OPERATIVE DIAGNOSIS: Bilateral breast cancer. INTRAOPERATIVE CONSULTATION: FSA1-FSA2: One focus with atypical cells defer to permanent.. Diagnosis called by Dr. to Dr. at (A). ADDENDUM:  SUMMARY OF IMMUNOHISTOCHEMISTRY/SPECIAL STAINS Material: Block B6 Population: Tumor Celis Stain/Marker:Result: Comment: HERCEPTIN Negative The interpretation of the above immunohistochemistry stain or stains is guided by published results in the medical literature, provided package information from the manufacturer and by internal review of staining performance and assay validation within the Immunohistochemistry Laboratory of the. The use of one or more reagents in the above tests is regulated as an analyte specific reagent (ASR). These tests were developed and their performance characteristic determined by the Department of Pathology
+
+--- Page 5 ---
+TSS: Laboratory at. They have not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. Special stains and/or immunohistochemical stains were performed with appropriately stained positive and negative controls. Gross Dictation:,  Microscopic/Diagnusuc bicratinn Final Review: Pathologist, ' Final Review: Pathologist. Final: Pathologist, Addendum: Pathoiogist Addendum Final: Pathologi
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diff --git a/output/text/27b0e747-777e-4aaa-b903-229d59d680be.txt b/output/text/27b0e747-777e-4aaa-b903-229d59d680be.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a41161c0d4ff0e8d8103477ad70e957ec0c2883f
--- /dev/null
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@@ -0,0 +1,15 @@
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+--- Page 1 ---
+1cs-0-3 C sri ome, Mtinvus/Pipi1ary I480f3 Path? Site: bruast, Jpon onty. qusdrst Css,4 cqep: : buat.' N'o's C50.l9 Fax: linical Case Report (For Collection of Cancerous Tissue) C:iterl UUID:ACA63606-681C-427F-8923-778AA7390795 Redacted Primary Tumc: Site TCGA-C8-A1HL-01A-PR HIPAADiscrepanc Informed Consent 93i I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Signature Date Name of Physician or Study Coordinator Clinical Information TMATSSAGENERADINFORMATIONOE Race Date of Birth (mm/dd/yyyy) Height Marital Status Temperature 1.584 3Fo c  Single   Married Gender Weight  Divorced  Widow  Blood Pressure Heart Rate 0/60MM 6siry  Male Female 516 MEANTOARAHISTORWORPRESENT ILENESS Chief Complaints: Iwumr n the bReaw+ Symptoms:Dke Clinical Findings: A kilWry hyrlndes Ve sua Performance Scale (Karnofsky Score):.  60-70 Symptomatic, in bed less than 50% of day  100 Asymptomatic  80-90 Symptomatic but Fully Ambulatory  20-30 Bed Ridden  40-50 Symptomatic, in bed more than 50% of day. but not bed ridden ORSALECURRENTMEDICATIONSA Frequency Date (mm/dd/yyyy) Drug Dose Route To To 1d To To To /
+
+--- Page 2 ---
+A9.0..... . :: PAST MEDICAL HISTORY Diagnosis/Disease/Disorder/Injury Diagnosis Date Treatment Status Basin.Cyst L003 ACOBGYNHISTORYMR  Menopausal Status Date of First Menses # of Pregnancies Pre-menopausa! yearsrll  Peri-Menopausal Date of Last Menses # of Live Births  Post-menopausal Birth Control:  Condom  Oral Contraceptive  iuD  Hormone Replacement N Therapy:  Other: SOCIALHISTORYA Occupation: Environmental Hazards: Smoking History. Current Status TYPE Packs/day Duration When Quit  yES no (yrs) (yr) Alcohol Consumption Current Status TYPE Drinks/day Duration When Quit  yes no (yrs) (yr) Drug Use Current Status TyPE Frequency Duration When Quit  yes no (yrs) (yr ASSARSK FAMIEYMEDICALHISTORYS E Relatiye  Diagnosis Age of Diagnosis bro A Cass NLABDATAAE Test Result Date Test Result Date Negative  Positive: .. CEA   Negative  Positive: HIV Negative CA 15-3  Positive:   Negative  Positive:  Hep B CA 19-9  Negative  Positive: Hep C   Negative  Positive:  Positive: PSA   Negative  Positive: AFP   Negative Other: Other:  Negative  Positive:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+ m ERDIAGNOSTICSTUDIES+M+ Study Results Date  Ultrasound Ntu X-Ray cT Endoscopy MRI Biopsy PAN CLINICAEDIAGNOSISAA Preoperative Clinical Diagnosis. es+ bent c Cauer Location of Suspected Involved Lymph Nodes Location of Suspected Distant Metastasis Let Axilla NO Clinical Staging Date of Diagnosis T2 Ns Mo Stage: Treatment Informationd ASAKPTSURGICAETREATMENTOCRRT Procedure Date of Procedure Patey's Swrnewy 'Primary Tumor Organ Detailed Location Size Bseaso Wlen-Dstrnuadsat Ax 6 x cm Extension of Tumor Lymph Nodes Description Location of Lymph Nodes. # of Lymph Nodes Axilla Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Organ Detailed Location Size Surgical Staging Na Mn Stage:A NEOADJUVENTHERAPY (Chemo Radiation Immuno, Hormonalr Molecular Dose. Frequency Date (mm/dd/yyy) Drug/Treatment Route To N To To 1 To To / 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Date: Collected by: - Date: Time: Preserved by:  +-SPECIMENTYPE (#of samples provided*c  Paraffin Block  Blood/$erum/Plasma Slide Frozen Normal Diseased Normal Diseased  Normal Diseased Normal Diseased x Time to LN2 Time to Formalin Time to LN2 min 60 minre 1D min 40 Primary Tumor Size Extension of Tumor Distance to NAT Organ Lgoar! 2 6 x4.Sx cm cm] Lymph Nodes # Examined # Metastasized Location Awilla 9 Distant Metastasis Detailed Location Size Organ Pathological Staging NT Mo Stage: Ill A- pT q Notes: 4
+
+--- Page 5 ---
+COnSOLIDaTED DIAgnOsTIc PAThOLOgy fORm* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION Diffuse + STRUCTURAL PATTERN Mosaic Streaming + Necrosis  Storiform Lymphocytic Infiltration XFibrosis Vascular Invasion X Palisading Clusterized X Cystic Degeneration Alveolar Formaion A Bieeding Myxoid Change. Indian File 2. Cellular features: P. aomoma/Calcification Sguamoys Adenomstous Squamoid Cell +  Sarcomatous + Lynphomatous Glandular cel! X Rownd Celi Spindle Cell Large Celul Cell Stratification Fibroblast Keratin Small Cell Secretion Osteoblast RS CeIl/RS Like Desmosome Intracyt. Vacuole Lipoblast Inflam. Cell Pear!  Gland formation X Myoblast  Plasma Cell Otherwise Specified: )180y Dr8! t3 8g7 N8OZ 2. Cellular Differentiation: Well Moderately Poor X Nuclear Atypia: Nuckear Appearanse Aniso Nucleosis Hyperchromatism Y  Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity Nuckear Grade ToAltrahry Histological Diagnosis: Comments: STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUT
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index 0000000000000000000000000000000000000000..e9c9b451e02d8a48a5a94b4b055d08ad9609ad1d
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+UUID: 166D77A-9C39-4886-9320-8946DA9AA69D zc-o-3 TCGA-A6-A567-01A-PR Redacted Oierscseurome NoS 8j40/3 CJ87 7/ 13 SURGICAL PATHOLOGY REPORT V1 SPECIMEN A. Lower anterior colon - sigmoid. B. Appendix CLINICAL NOTES PRE-OP DIAGNOSIS:  Sigmoid colon cancer Post-op DIAgnosis: Rectal cancer - involvement of apical nodes ? Implant lateral mesentery. GROSS DESCRIPTION A.  Received fresh, subsequently fixed in formalin, labeled "sigmoid colon". The specimen consists of a 22 cm. long portion of colon which is stapled at the proximal end, opened at the distal end. The proximal end is inked blue and the distal end is inked black. The specimen is opened to show a pink tan smooth glistening mucosa with normal to abundant folds. The circumference of the proximal end is 4.5 cm. and the circumference at the distal end is 7.5 cm. The specimen shows a 4.8 x 3.5 x 1 cm. tumor which comes within 5 cm. of the distal margin. The serosa of the specimen. is pink tan smooth glistening and predominantly covered with yellow lobular fat. The specimen shows a 2.5 x 1.5 cm. serosal umbilication. This umbilication is inked blue. The tumor also shows gross invasion through the muscularis propria into the fat. Multiple lymph nodes are grossly identified in the surrounding fat..  There is a focus of mesenteric margin (peduncle) which feels somewhat indurated. The proximal lymph node may be present in this area. There is also a 1.5 x 1.5 irregular indurated focus on the surface coming in within 9 cm. of the proximal margin. The cut surface of. this induration site shows possible tumor present. There is also a small polyp grossly identified which is 0.5 cm. this is located 3 cm. from the distal margin. This polyp shows no invasion grossly. identified. Representative sections of the specimen are submitted for tissue procurement. Representative sections of the remainder of the specimen are submitted as follows:. BLOCk sumMARy: 1 - Representative luminal margins; 2 - mesenteric margin shave; 3 - polyp full thickness; 4 - tumor to serosal umbilication; 5 - tumor to normal; 6 - tumor to fat; 7 - radial margin; 8 - indurated surface nodule with possible tumor; 9-12 nine possible lymph nodes each; 13 - four possible lymph node; 14 lymph node at mesenteric peduncle bisected; 15 - renresentative section of possible mottled lymph node..  RS15 B. Received in formalin labeled "appendix" is a 6 x 0.5 cm.  unremarkable appendix partially covered with pink tan smooth glistening serosa and yellow lobular fat.  The specimen is sectioned to show an intact wall with an average thickness of 0.3 cm. The lumen ranges from pinpoint to 0.??.  Representative sections of the specimen are submitted in one cassette with the proximal end inked. RS1 MICROSCOPIC DESCRIPTION Microscopic sections of the sigmoid tumor reveals a.  moderate to poorly differentiated colonic adenocarcinoma. which has extended through the bowel .wall into the mesenteric fat.
+
+--- Page 2 ---
+The area of irregular indurated soft tissue at the mesenteric root does not contain any carcinoma. There are three positive mesenteric lymph nodes present. One of these is present at the mesenteric root and represents the most proximal lymph node in the dissection. There is a soft tissue metastasis present in the mesentery as well. The results of the evaluation of the resection are summarized in the following template. Histologic type:  Adenocarcinoma. Histologic grade:  Moderate to poorly differentiated.  Primary tumor (pT): Tumor invades through the colon wall into the mesenteric fat (pT3). Proximal margin: Negative.. Distal margin: Negative.. Circumferential (radial) margin: Negative. Vascular invasion:.  Negative. Regional lymph nodes (pN): Three of 41 mesenteric lymph nodes contain metastatic adenocarcinoma (pN1). Non-lymph node pericolonic tumor: Present. Distant metastasis (pm): Tumor is present as a soft tissue metastasis in the colonic mesentery (pml). Other findings: Adenomatous polyp. Appendix without significant histopathologic findings.. DIAGNOSIS A. Colon, sigmoid, segmental resection: Invasive moderate to poorly differentiated colonic adenocarcinoma extending through the wall of the colon into the pericolonic fat. Proximal, distal and radial margins of resection are free of tumor. Three of 41 mesenteric lymph nodes contain metastatic adenocarcinoma (3/41). Soft tissue metastasis present in the soft tissues of the lateral mesentery. Adenomatous polyp. B. Appendix, incidental appendectomy:. No significant histopathologic findings..  End Of Report
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index 0000000000000000000000000000000000000000..652a296de2835721e007846a0436f57c6e126161
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+History Case Pathology Report DOB: Sex: M  Physician: Received: Pathologist: Accession: Case type: Surgical History ** For cases prior to  the section "SPECIMEN" may have been added. ** Suppi FmentaL repOrt SUPPLEMENTAL REPORT DIAGNOSIS: (b)  WIDEFIELD LARYNGECTOMY: DECALCIFIED SECTIONS DEMONSTRATE INVASIVE MODERATELy DIFFERENTIATED CARCINOMA INVADING THROUGH THE THYROID CARTILAGE INTO PRELARYNGEAL Soft tissue. (see comment) comment: This supplemental report is being issued to give the results of section submitted' for decalcification. This report does not alter the. previously issued diagnosis. DIAGNOSIS A)  AnTERIOR COMMISSURE: InVasIVE mOderATeLy DifFEREnTIaTed SqUAMoUs CEll CArcInOMA. (B) widefield LAryngectomy: INVASIVE MODERATELY DIFFERENTIATED SQUAMOUS CELL CARCINOMA INVOLVING ANTERIOR COMMISSURE, RIGHT AND LEFT TRUE AND FALSE VOCAL CORDS WITH INVASION OF THYROID CARTILAGE AND EXTENSION INTO PRE-LARYNGEAL SOFT Tissue AnD SubglottIC extension. (See COmmEnT) Tracheal, mucosal and anterior soft tissue margins, no tumor present. Right and left aryepiglottic folds, pyriform sinuses, and epiglottis,. no tumor present. Eleven lymph nodes, no tumor present.. Right neck dissection; six lymph nodes, no tumor present (0/6 subdigastric). Left neck dissection; three lymph nodes, no tumor present (0/3. subdigastric). Two lymph nodes anterior midline, no tumor present. Lymphocytic thyroiditis. One' parathyroid gland, no tumor present.. Sections of bone pending decalcification.. A supplemental report to. follow. COMMENT The tumor (3.0 x 2.6 x 1.5 cm) appears to arise in the anterior. commissure with extension through' the thyroid cartilage into the anterior soft tissues and with extensive submucosal extension into the right and left true and false vocal cords.. Page 1 of 2 History Case Pathology Report History Case Pathology File under: Pathology
+
+--- Page 2 ---
+History Case Pathology Report. DOb: Sex: M Physician: Pathologist:  Accession: Case type: Surgical Historye SPECIMEN (A) ANTERIOR COMMISSURE: (b) WIDEFIELD LARYNGECTOMY: SNOMED CODES T-24100,M-80703 Page 2 of 2 History Case Pathology Report History Case Pathology File under: Pathology
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diff --git a/output/text/27daf303-fb11-4fcd-8fe4-840a494560b5.txt b/output/text/27daf303-fb11-4fcd-8fe4-840a494560b5.txt
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index 0000000000000000000000000000000000000000..efeaf080a67676a736ec0fdaca15631b762beac5
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+--- Page 1 ---
+UUID:9D430275-A98A-4C89-BE8A-95D5DDB1BC88 TCGA-22-A93D-01A-PR Redacted ID-O-3 ceQ 8Q6tJ3 Pathology Report. O 4/28f14 Final Diagnosis A. *RIGHT PERITUMORAL FAT,* PARTIAL NEPHRECTOMY: Fibroadipose tissue, negative for carcinoma. B. *RIGHT RENAL MASS INFERIOR MARGIN," PARTIAL NEPHRECTOMY: Fibroadipose tissue, negative for carcinoma.. C. *RIGHT RENAL MASS SUPERIOR MARGIN,* PARTIAL NEPHRECTOMY: Fibroadipose tissue, negative for carcinoma.. D. *RIGHT RENAL MASS POSTERIOR MARGIN,* PARTIAL NEPHRECTOMY: Fibroadipose tissue,negative for carcinoma. E. "RIGHT RENAL MASS," PARTIAL NEPHRECTOMY: Renal cell carcinoma, papillary type 2, Fuhrman nuclear grade 3 of 4.. Papillary adenoma,Q.1 cm size as measured on slide See Key Pathological Findings. the attending pathologist, personally reviewed the entire case and rendered the final. diagnosis. Electronically Signed Out by Key Pathological Findings Tumor type:  Renal cell carcinoma, papillary type 2 Nuclear grade: Fuhrman nuclear grade 3 of 4. Pattern of growth: Papillary. Tumor size: 4.0 cm (size of tumor based on current specimen). Invasion through Renal capsule: Not identified. Invasion of Gerota's Fascia:. Not applicable. Renal vein invasion: Not applicable. Surgical margins: Free. Non-neoplastic kidney: Mild chronic inflammation and tocal glomerulosclerosis. Adrenal gland: Not applicable. Lymph nodes: Not applicable. Pathologic stage: pT1aNxMx (size of tumor based on current specimen). Specimen(s) Received RIGHT PERITUMORAL FAT B RIGHT RENAL MASS INFERIOR MARGIN FS c RIGHT RENAL MASS SUPERIOR MARGIN FS D RIGHTRENAL MASS POSTERIOR MARGIN FS E RIGHT RENAL MASS FS Clinical History Renal cell carcinoma, status post right partial nephrectomy.
+
+--- Page 2 ---
+Preoperative Diagnosis. Renal cell carcinoma, status post right partial nephrectomy. Intraoperative Consultation. FSB1. RIGHT RENAL MASS INFERIOR MARGIN: Perpendicular cross section, adipose tissue - not cut, negative. FSC1.RIGHTRENALMASS SUPERIOR MARGIN Perpendicular, adipose tissue, not cut well, negative. FSD1. RIGHT RENAL MASS POSTERIOR MARGIN: Perpendicular, negative (adipose tissue, not cut well). Comment: These frozen section diagnoses/resuits were communicated to and acknowledged by Dr.  have performed the intraoperative consultations and issued the above diagnoses. Gross Description A. The specimen is received fresh labeled "right peritumoral fat."The specimen consists of multiple, irregular, unoriented tragments of lobulated adipose tissue, which range from 1 to 3.5 cm in. greatest dimension. The specimen is serially sectioned to reveal a grossly unremarkable cut surface.. No tissue is submitted to the Tissue Procurement Laboratory. Representative sections of the specimen are submitted in 5 cassettes,A1-A5. B. The specimen is received fresh labeled "right renal mass, inferior margin." The specimen. consists of an irregular fragment of fibroadipose tissue measuring 1.2 x 0.6 x 0.6 cm. The specimen. is oriented according to the surgeon's designation and inferior margin is inked blue. The specimen is. bisected and submitted entirely for frozen section as FsB1. C. The specimen is received fresh labeled "right renal mass, superior margin.* The specimen consists of an irregular fragment of fibroadipose tissue measuring 1.5x0.4 x 0.3 cm. The specimen is oriented according to the surgeon's designation and the superiar margin is inked black. The specimen is bisected and submitted entirely for frozen section as FsC1. D. The specimen is received fresh labeled *right renal mass, posterior margin.* The specimen consists of an irregular fragment of fibroadipose tissue measuring 1.2 cm in greatest dimension. The specimen is oriented according to the surgeon's designation and the posterior margin is inked black. No tissue was submitted to the Tissue Procurement Laboratory. The specimen is submitted entirely for frozen section as FSD1.. E. The specimen is received fresh labeled "right renal mass." The specimen consists of a partial nephrectomy with a moderate amount of lobulated adipose tissue of the renal hilum attached. The specimen measures 7 x 4 x 4.5 cm. The specimen is oriented by a surgeon and is inked as follows:  parenchymal resection margin is inked black, anterior adipose tissue resection margin is inked green,.
+
+--- Page 3 ---
+posterior orange, superior black, inferior blue. On sectioning, the specimen reveals a roughly ovoid,. ill-defined rubbery tumor mass,which measures 4 x 4 x 3.8 cm. Cut surface of the tumor is tan-red-brown, focally hemorrhagic. The tumor is bulging capsule and extends to within 0.2 cm of the. closest parenchyma resection margin. Representative sections of the specimen are submitted to the. Tissue Procurement Laboratory. The superior, inferior, and posterior resection margins are received. for frozen section analysis in separate contains. Representative sections of the specimen are submitted in 10 cassettes as follows: E1-E2: Tumor in relation to the closest anterior adipose tissue resection margin. E3-E10: Tumor in relation to the closest parenchymal resection margin,  perpendicular sections. Cassette E10 mirror image of the section submitted to the Tissue Procurement Laboratory. w 1/3/4 Primary Tumor Site Discrepancy HIPAA Discrepan Case is (circle DISQUALIFIE
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index 0000000000000000000000000000000000000000..6223e6b30e8cd3954af16bda6383d2eeb573aa6b
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+UUID:FCD998EA-2EEA-4A94-80A6-D87F962BBC87 TCGA-OR-ASLP-01A-PR Redacted Procedure: Right adrenalectomy Gross description: tumor is 198g; measuring 8.5 x 7.5 x 6cm. Diagnosis: tumor has oxyphilic cells. Weiss score = 5, consistent with carcinoma. Based on paper from Bisceglia et al, this tumor is classified as tumor with malignancy potential. No lymph node metastases (+0/30). 1.4 hyperplastic nodule on segment V of liver. s/p cholecystectomy (no change in histology of gallbladder). tcd-o-3 arcinomo, adrenal csrticil. 83 70/3 Site:BAdrena!Gland Cortek C 74.D 9sJ x/y1 3
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diff --git a/output/text/282c488e-0847-4b02-9c90-96689a71e2d9.txt b/output/text/282c488e-0847-4b02-9c90-96689a71e2d9.txt
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+PATIENT HISTORY: Malignant neoplasm.  PRE-OP DIAGNOSIS: Malignant neoplasm tonsil, malignant neoplasm mouth,. POST-OP DIAGNOSIS: Same. PROCEDURE: Dissection neck, free flap.. FINAL DIAGNOSIS: PART 1: SOFT PALATE MARGIN, BIOPSY -- NO TUMOR SEEN. PART 2: POSTERIOR TONSILLAR PILLAR, BIOPSY - NO TUMOR SEEN. PART 3: LYMPH NODES, RIGHT NECK LEVEL 1, BIOPSY - A. TWO BENIGN LYMPH NODES (0/2).  B.  SUBMANDIBULAR GLAND WITH NO SIGNIFICANT PATHOLOGIC CHANGE. PART 4: SUPERFICIAL MANDIBLE MARGIN, BIOPSY - NO TUMOR SEEN. PART 5: RIGHT TONSILLAR--RETROMOLAR TRIGONE REGION, COMPOSITE RESECTION - A. INVOLVING MANDIBLE. B.  NO ANGIOLYMPHATIC INVASION SEEN. C. NO PERINEURAL INVASION SEEN. D.  FOCI OF INVASIVE SQUAMOUS CELL CARCINOMA INVOLVING ANTERIOR MANDIBULAR BONE MARGIN AND LATERAL SOFT TISSUE MARGIN. E.  SEVERE DYSPLASIA PRESENT AT ANTERIOR SOFT TISSUE AND MEDIAL SOFT TISSUE MARGINS. F. PATHOLOGIC STAGE: pT4 N0 MX. PART 6: RIGHT ALVEOLAR NERVE, BIOPSY - NO TUMOR SEEN. PART 7: RIGHT RETROMOLAR TRIGONE, BIOPSY - NO TUMOR SEEN. PART 8: ANTERIOR LABIAL MARGIN, BIOPSY - NO TUMOR SEEN. PART 9: LYMPH NODES, RIGHT NECK LEYELS 2, 3, AND 4, DISSECTION - TWENTY-FOUR BENIGN LYMPII NODES (0/24). PART IO: BONE MARROW MANDIBLE, RIGHT, BIOPSY - Page 1 ot &.
+
+--- Page 2 ---
+My signature is attestation that I have personally reviewed the submitted material(s) and the final diagnosis reflects that evaluation.. GROSS DESCRIPTION: The specimen is received in a total of 10 parts. Part 1 received fresh with the patient's name, initials labeled "soft palate margin" and consists of a 0.8 x 0.6 x 0.5 cm of pink-. hemorrhagic, soft tissue, entirely submitted following intraoperative consult labeted 1FS. Part 2 received fresh with the patient's name, initials , labeled "posterior tonsillar pillar" consists of two irregular portions of pink- hemorrhagic, soft tissue, 1.0 x 0.5 x 0.5 cm and 0.7 x 0.4 x 0.4 cm. The soft tlssue is entirely submitted following intraoperative consult labeled 2AFS.. Part 3 received unfixed with the patient's name, initlals labeled "right neck level I" consists of a 4.0 x 2.5 x 1.5 cm, 9.0-g light tan submandibular gland, with an attached 3.0 x 3.0 x 0.7 cm of pink and hemorrhaglc fat and soft tissue. The gland on cross- section is grossly unremarkable. A representative section Is submitted labeled 3A. *Two lymph nodes dissected from the attached fat are entirely submitted along with remaining adlpose tlssue labeled 3B and 3C. Part 4 received fresh with the patient's name, initials labeled "superliclal mandible margln" and conslsts of a 2.1 x 0.9 x 0.6 cm of pink and hemorrhagic soft tissue, entirely submitted rollowing intraoperative consult labeled 4AFS.. Part 5 received fresh with the patlent's name, initlals , labeled "right composite resectlon' conslsts of a right composite resection with overall dimensions 8.0 x 5.5 x 4.4 cm. The mandible, 6.0 x 4.0 x 1.0 cm has hemorrhagic eroslon of the cortlcal bone at the Iateral ramus. The attached soft tlssue consists of buccal mucosa, retromolar trigone and floor of mouth measurlng 7.0 x 2.0 x 1.0 cm, with an irregular, tumor withIn the posterior oral region measuring 2.1 x 1.7 x 1.0 cm. The lesion comes to wlthin 1.0 cm of the anterlor soft tissue margin, 1.0 cm of the posterior soft tissue margin, 0.6 cm of the lateral soft tissue margin 0.7 cm of the medlal soft tissue resectlon margin and O.5 cm of the deep margin of resectlon. A coronal section exposes tumor eroding the mandbular cortical bone at the medlal aspect, possibly extending to the lateral. cortical surface. The bone resectlon margins are grossly free of tumor. Digital images are taken. Representative tumor and normat tlssue Is submitted for  banking. Ink code: Blue- lateral Black- medial Green- anterlor Yellow- posterlor. Orange- deep The following secllons are submitted: 5A. antetlor mandlbular resectlon shave margin, followlng complex decalclflcation 53. posterior mandibular shave margin, following complex decalclficatlon 5C. anietlor soft tissue shave margin Page 2 of 8
+
+--- Page 3 ---
+Pathology Report 5D. posterior soft tissue shave margin 5E. lateral soft tissue shave margin 5F. medial soft tissue shave margin and salivary gland 5G. deep soft tissue 5H. - J. additional sections of lesion with relation to tonsil and deep aspects 5K. - L. tumor extending into mandible, following complex decalcification Part 6 received fresh with the patient's name, initials. ?, labeled "right alveolar nerve" consists of a 0.9 x 0.6 x 0.4 cm of pink, soft tissue, entirely submitted following intraoperative consult labeled 6AFS. Part 7 received fresh with the patient's name, initials labeled "right retromolar trigone" consists of a 1.4 x 0.4 x 0.4 cm resection of pink hemorrhagic, soft tissue, entirely submitted following intraoperative consult labeled 7AFS. Part 8 received fresh with the patient's nane, initials labeled "anterior labial margin" consists of a 1.5 x 0.4 x 0.4 cm of pink. and hemorrhagic, soft tissue, entirely submitted following intraoperative consult labeled 8AFS. Part 9 received unfixed with the patient's name, initials labeled "right neck level 2, 3, 4 (stitch on two) consists of 3 pieces of. yellow and hemorrhagic fat and soft tissue ranging from 3.0 x 1.0 x 0.5 cm to 6.0 x 4.0 x 1.5 cm. The largest portion of tissue has an attached black silk suture. Lymph nodes dissected from the larger portion are submitted as zone Il lymph nodes in cassettes. 9A through 9E. Lymph nodes dissected from the remaining tissue are also entirely submitted labeled 9F.. Part 10 received fresh with the patient's name, initials labeled "bone marrow mandible right" consists of a 0.4 x 0.2 x 0.2 cm of dark red, soft to friable tlssue, entirely submitted following intraoperative consult labeled 10AFS. INTRAOPERATIVE CONSULTATION: 1FS:  SOFT PALATE, MARGIN, BlOPSY (frozen section)- A. BENIGN B.NO TUMOR SEEN 2FS: POSTERIOR TONSILLAR PILLAR, BIOPSY (frozen sectlon) A.  BENIGN B. NO TUMOR SEEN ( 4FS: SUPERFICIAL MANDIBLE MARGIN, BIOPSY (frozeh sectlon) BENIGN I3.NO TUMOR SEEN 6FS: RIGHT ALVEOLAR NERVE, BIOPSY (frozen sectlon)- A. BENIGN B. NOTUMOR SEEN 7F9: RIGHT RETROMOLAR TRIGONE, BIOPSY (frozen section) A. BENIGN B.  NO TUMOR SEEN 8FS: ANTERlOR LABIAL MARGIN, B|OPSY (frozen sectlon)- h. BENIGN  NO TUMOR SEEN 10FS:  BONE MARROW MANDIBLE. RIGHT, BIOPSY (frozen sectlon) Page 3 of 6
+
+--- Page 4 ---
+A.  BENIGN B.  BONE FRAGMENTS, NO TUMOR SEEN MICROSCOPIC: Microscopic examination substantiates the above diagnosis. The following statement applies to all immunohistochemistry, insitu hybridization (isH & FisH), molecular anatomic pathology, and immunofluorescence testing: The testing was develoned and its performance characteristics determined by the required by the CLiA  regulations. The testing has not been cleared or approved for the specific use by the U.s. Food and Drug h, Department of Pathology, as. Administration, k A has determined such approval is not necessary for clinical use. Tissue fixation ranges from a minimum of to a maximum of. This laboratory is certified under the Clinical Laboratory Improvement Amendments of complexity clinical testing. Pursuant to the requirements of CLIA, AsR's used in this laboratory have been established and verified for ("CLiA") as qualified to perform high- accuracy and precision. Additional information about this type of test is available upon request. CASE SYNOPSIS:  SYNOPTIC DATA - PRIMARY UPPER AERODIGESTIVE TRACT AND SALIVARY GLAND TUMORS SPECIMEN TYPE: Resection: Composite resection TUMOR SITE: Other: Right retromolar trigone TUMOR SIZE: Greatest dimension: 2.1 cm. HISTOLOGIC TYPE: Squamous cell carcinoma, conventional HISTOLOGIC GRADE: G2 PATHOLOGIC STAGING (pTNM): pT4 pN0 Number of reglonal lymph nodes examined: 26 Number of reglonal lymph nodes involved: 0  MARGINS: pMX Margin(s) involved by tumor Locatlon(s): anterior mandible margin and lateral soft tlssue margin VENOUS/LYMPHATIC (LARGE/SMALL VESSEL) INVASION (V/L): Absent PERINEURAL INVASION: Absent ADDITIONAL PATHOLOGIC FINDINGS: Epithellal dysplasia HISTO TISSUE SUMMARY/SLIDES REVIEWED: Part 1: Soft palate matdin Taken: Stain/c. BIOCK H&E x 1 AFS Part 2: Posterlor tonsllar nllar Taken: Stain/on Block H&E x 1 AF9 Taken: Stain/cm Block Page 4 of 0
+
+--- Page 5 ---
+Pathology Report. H&E x 1 A H&E x 1 B H&E x 1 c Part 4: Superior mandible marain Taken: Stain/cm BIOCK H&E x1 AFS Part 5: Right composite mandible resection Taken: Stain/cnt Block DC x1 A H&E x 1 A H&E x1 B H&E x 1 C H&E x 1 D H&E x 1 E H&E x1 H&E x 1 G H&E x 1 H H&E x 1 1 H&E x1 J H&E x 1 K H&E x 1 L. IMSU x 7 (none) Taken: Stain/c BIOCK H&E x 1 AFS Part 7: Riaht retromalar tride. Taken: Stain/cn HHE x1 AFS H&E x 1 AFS Part 8: Anterior labial mardin Taken: Stain/c BIOCK H&E x1 AF9 Part 9; Riaht neck levele 2 3 A Taken Stain/cm BtoCk H&E x1 A H&E x 1 B H&E x 1 c H&E x 1 D H&E x 1  W LL H&E x 1 Page I ot 6.
+
+--- Page 6 ---
+Pathology Report Part 10: Bone marrow riaht mandible Taken:  Stain/ca H&E x 1 AFS ICD-9 Diagnosis Codes: 000 Page 6 of 6
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diff --git a/output/text/283b98d2-02a5-4ce5-b560-3907309b4fc0.txt b/output/text/283b98d2-02a5-4ce5-b560-3907309b4fc0.txt
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index 0000000000000000000000000000000000000000..ad4c15628a7c15abb9e7ed9d2e15b0cb374ceed5
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+--- Page 1 ---
+DIAGNOSIS: 1.Right kidney: Renal cell carcinoma, see synoptic report. 2. Tissue from vena cava: Nodular piece of fibrovascular tissue. No lymph node identified. Kidney: Nephrectomy,partial or radical Synopsis MACROSCOPIC Specimen Type: Right radical nephrectomy Focality: Ur'scel. Tume ce dimeneio8.3 cm. Macroscopic extent of tumor: Tumor limited to kidney MICROSCOPIC Histologic Type: Chromophcbe renal cell carcinoma.
+
+--- Page 2 ---
+Histologic Grade: G2: Nuclei slightly irregular, approximately 15 microns; nucleoli evident;. EXTENT OF INVASION Primary Tumor: pT2: Tumor more than 7 cm in greatest dimension, limited to the kidney.. Regional Lymph Nodes: pNX: Cannot be assessed. Lymph Nodes: None submitted. Distant metastasis: pMX: Cannot be assessed. Margins: Margins uninvolved by invasive carcinoma. Venous invasion: Absent. Additional Pathologic Findings: Inflammation (type): chronic. Tumor cells stain for colloidal iron. Clinical: Renal carcinoma - right kidney; Gross: Part 1 is received fresh and additionally labeled with snd"right kidney."The specimen consists of a kidney specimen with perinepnnc iat that measures 19 cm x 17 cm x 10 cm. The ureter is patent. The specimen is inked in black, and breadloafed to reveal an 8.3 cm. mass within the kidnev parenchvma that arosslv ahuts the oerineohric fat The tumor has two distinct areas one area is tan and hemorrhagic, and measures 6.2 cm x 6 cm x 4 cm. The other part of the mass is a nodule that measures 4.3 cm x 4 cm x 2.5 cm. The ureteral margin is in A and the vascular margins are in B. A random section of tumor is in C. The tumor with respect to perinephric fat is in D, the tumor with respect to inked margin is in E. Representative sections of the tumor with respect to fat with resection margin is ink F. Representative sections of the tumor are in G-J. K = representative sections of tumor with fat and inked capsule, L = representative sections of tumor with respect to kidney parenchyma. M = representative sections of kidney parenchyma not effected by the tumor and contains representative sections of lymph nodes from the hilum. O = another representative sections of tumor.. Part 2 is additionally Iheled "venacava! lymph node". It consists of a 0.7 x 0.5 cm tragment of pnestosget! R cntreysedinp.
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diff --git a/output/text/285db86e-e791-4afb-8d8a-4c143fc4ca09.txt b/output/text/285db86e-e791-4afb-8d8a-4c143fc4ca09.txt
new file mode 100644
index 0000000000000000000000000000000000000000..21c7bb804fc469c2abd96fb0666fe907bc62549f
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+
+--- Page 1 ---
+zQD o 3 Operative Procedure: 8360/3 Left laparoscopic radical nephrectomy 8I: OKuduy NS C649 Specimen Received: Left kidney go 1/z[13 Final Pathologic Diagnosis: Kidney, left, radical nephrectomy: Tumor histologic type: Papillary renal cell carcinoma type 1,  multifocal (5 tumors) and clear cell renal cell carcinoma (1 tumor) Sarcomatoid features (%): Not identified Tumor size: 6.7 cm (greatest dimension, largest papillary renal cell carcinoma) Other dimensions: Smaller foci of papillary renal cell carcinoma (4 tumors, ranging from 0.6 to 1.7 cm) Small focus of clear cell renal cell carcinoma (0.8 cm;. slide A11) Macroscopic extent of tumor:. Confined to the kidney Focality:  Multifocal Number of tumors: 6 Fuhrman grade: 2 of 4 UUID:681C28DC-CE0A-400D-BF7E-0836C603C388 tcgA-gL-A59t-01a-pr Redacted Microscopic extent of tumor: Perinephric fat invasion: Not identified Renal sinus invasion: Not identified Other: Not applicable Renal vein involvement: Not identified Adrenal gland present: No Cancer at resection margin: No Pathologic findings in nonneoplastic kidney: Numerous papillary adenomas. Hilar lymph nodes present: None Pathologic stage pT1b pNX pM-not applicable The examination of this case material and the preparation of this report were. Gross Description: The specimen is received in formalin labeled with the patient's name, and labeled "left kidney.' Specimen components and dimensions: The specimen consists of a left kidney received with a moderate amount of attached fat. The specimen has overall dimensions of 23.4 x 8.7 x 5.2 cm. The renal parenchyma has dimensions of 14.2 x 6.4 x 3.8 cm. An adrenal gland is not present. The specimen is received. previously inked and incised. Size, appearance, and location of tumor: The specimen is remarkable for. numerous nodules/masses that range from 0.2 x 0.2 by less than 0.2 cm to 6.7 x
+
+--- Page 2 ---
+5.9 x 4.4 cm. The dominate mass resides within the lower pole. The masses are. yellow-orange to red-brown, granular and homogenous to variegated and focally. hemorrhagic. These nodules/masses range from ill defined to well defined and encapsulated. The total number of nodules/masses is approximately 12. Renal capsule/renal sinus: Some of the nodules/masses extend to, but not beyond the capsule. The renal sinus fat does not grossly appear to be invaded. Renal vein: The renal vein is not invaded and is grossly negative at the margin. Lymph nodes (size, number, & location): An exhaustive search of the hilar fat to include the use of palpation and chemical clearing agent reveals no grossly appreciable lymph nodes. Other findings: Additionally, there are a few cysts present that range from. minute to 1.2 cm in greatest dimension. The cysts contain gray-yellow, serous fluid. The cortical surface is red-brown, granular with numerous ill defined,. yellow-orange granular foci, which are grossly similar to the aforementioned nodules/masses. The renal parenchyma is red-brown with an ill defined to well defined corticomedullary border and a cortical thickness that maximizes at approximately 0.5 cm. Additionally, there are a few ill defined, yellow-orange granular foci present, which are grossly similar to the aforementioned nodules/masses. Some of the papillary tips are hemorrhagic. The urothelium is. gray-white, smooth and glistening with some edema.. Blocks submitted: 1  vascular and ureter margins en face;. 2-5  dominant nodule/mass to include renal sinus fat in cassettes 2-3 and capsule and inked external surface in cassettes 4 and 5; 6-9  smaller nodules/masses to include renal sinus fat in cassettes 6-7 and capsule and inked external surface in. cassettes 8 and 9; 10  ill defined, yellow-orange granular foci;. 11 cysts; 12 hemorrhagic papillary tip; 13 normal most renal parenchyma and urothelium. Gross images have been taken of the specimen. Microscopic Description: The final diagnosis of each specimen incorporates the microscopic examination findings. END OF REPORT Taken: DOB: (Age: Gender: M
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diff --git a/output/text/286a199f-449d-450e-9a34-371f0a3b20fc.txt b/output/text/286a199f-449d-450e-9a34-371f0a3b20fc.txt
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+
+--- Page 1 ---
+BREAST TISSUE CHECKLIST "//E Specimen type: Mastectomy 3 Specimen size: Not specified Tumor site: Breast Tumor size: 3.2 x 3.2 x 3.2 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinoma Histologic grade:. Tumor extent: Not specified -0-001 Lymph nodes: 0/5 positive for metastasis (Regional 0/5) Extracapsular invasion of the lymph nodes: Not specified Right, upper Margins: Not specified. outer quadrant Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified cted Mitotic count (25x): Not specified Mitotic count (40x): Not specified 10 Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments.: None.
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diff --git a/output/text/286b4ff0-331b-4c0c-9c7e-f39ed04d8861.txt b/output/text/286b4ff0-331b-4c0c-9c7e-f39ed04d8861.txt
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index 0000000000000000000000000000000000000000..d3548ae0b01ca96ed9938eae52e378dc1b65d02d
--- /dev/null
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+
+--- Page 1 ---
+UUID:79A10C4B-1B5F-47BB-99EA-E694FB341696 TCGA-LL-A8F5-01A-PR Redacted RUN DATE: PAGE 1 RUN TIME: RUN USER: PATIENT ACCT #: LOC: AGE/SX:   ROOM: REG DR: DOB: BED: STATUS : SPEC #: RECD: STATUS: PERFORMED AT COLL : TIME IN FORMALIN: hrs. COLD ISCHEMA TIME: mins. CLINICAL INFORMATION: Pre-Op Diagnosis: Remarks: Specimen(s): A. Right breast lumpectomy 10.0:3 B. 1st sentinel lymph node AS C. 2nd sentinel lymph node. orsinsnis,riryitueline Lli 8500 MICROSCOPIC DIAGNOSIS C50.4 AI4[1414 A. RIGHT BREAST LUMPECTOMY: INVASIVE DUCTAL CARCINOMA SEE COMMENT FOR DETAILS  FIRST SENTINEL LYMPH NODE: TWO REACTIVE LYMPH NODES C. SECOND SENTINEL LYMPH NODE: ONE REACTIVE LYMPH NODE COMMENT(S) COLLEGE OF AMERICAN PATHOLOGISTS' PROTOCOL FOR EXAMINATION OF SPECIMENS WITH INVASIVE CARCINOMA OF THE BREAST, BASED ON AJCC/UICC TNM. 7TH EDITION The following classification should be adjusted based on additional clinical information. PROCEDURE: Right breast lumpectomy and sentinel lymph node biopsies LYMPH NODE SAMPLING: Sentinel lymph nodes SPECIMEN LATERALITY: Right HISTOLOGIC TYPE: Invasive.ductal.carcinoma TUMOR SIZE: 4 cm HISTOLOGIC GRADE: Tubular differentiation: Score 3. Nuclear pleomorphism: Score 3 Mitotic rate: Score 3 Overall grade: Grade 3 TUMOR FOCALITY : Single focus of invasive carcinoma. DUCTAL CARCINOMA IN SITU: Indeterminate EXTENT OF TUMOR: Skin: Uninvolved by invasive carcinoma MARGINS : Margins uninvolved by invasive carcinoma ** CONTINUED ON NEXT PAGE **
+
+--- Page 2 ---
+RUN DATE: PAGE 2 RUN TIME: Specimen Inquiry RUN USER: Lab Database: SPEC #: PATIENT: (Continued) COMMENT(S) (Continued) Distance from closest margin: 6 mm, deep/posterior LYMPH NODES: Number of sentinel lymph nodes examined: 3 Total number of lymph nodes examined: 3 Number of lymph nodes with macrometastasis: 0 Number of lymph nodes with micrometastasis: 0 Number of lymph nodes with isolated tumor cells: 0 Number of lymph nodes without tumor cells identified: 3 PATHOLOGIC STAGING: Primary tumor: pT2 Regional lymph nodes: pN0 (i-) Distant metastasis: Not applicable GROSS DESCRIPTION: Received fresh in the operating room labeled with the patient's name and "right breast lumpectomy" with request for gross evaluation of margins as well as selection of tissue for tissue banking is a lumpectomy specimen which weighs 131 grams and measures 9 x 8 x 5 cm. It is partially covered by a 9 x 1.5 cm ellipse of dark brown skin. Two sutures orient the specimen as follows: long suture is 10:30 and short suture is 4:30. A palpable mass is present within the specimen.. The tissue surrounding the mass moves easily. The specimen. is inked as follows: 10:30-4:30 blue, 4:30-10:30 black. 4:30 edge red. 10:30 edge yellow. and daep/posterior green. The specimen is serially sectioned revealing a fairly well circumscribed grayish-tan mass with homorrhagic needle tracts which measures 4 cm in length. 3 cm in dopth, and 3 cm in width. Towards the 4:30 aspect. the tumor has a somewhat more lobulated appearance. The margins are negative with the closest margin deep which measures 1.5 cm. A portion of the tumor is provided to the tissue bank coordinator.  The specimen is placed in formalin with sections to be held overnight for optimum formalin fixation.. A1 skin and underlying breast tissue A2~A3 the tumor as it most closely approximates to green. inked margin A4 tumor as it most closely approximates to blue. inked margin. A5 additional representative section of tumor A6 tumor grossly extending into surrounding ducts A7 section of fibrotic area near the red. inked margin B. In formalin. labeled with the patient's name and "first sentinel lymph node" is a 2.5 x 2 x 1 cm ovoid tan lymph node covered by a small amount of adipose tissue. On cross section. the node is largely composed of adipose tissue. It is totally submitted in blocks B1 through B3 per sentinel lymph node protocol. The specimen was evaluated late in the day and is found to be unfixed. It is held for overnight fixation prior to tissue processing. C. In formalin. labelod with the patient's name and "second sentinel lymph node" is a 1.5 x 1.5 x 1 cm ovoid portion of fatty tissue which contains a 1.5 x 1 x 0.5 cm fatty lymph node. The lymph node is submitted in block c1 to be held for overnight formalin fixation. prior to further tissue processing. * CONTINUED ON NEXT PAGE **
+
+--- Page 3 ---
+RUN DATE : PAGE 3 RUN TIME RUN USER: SPEC # PATIENT: (Continued) MICROSCOPIC DESCRIPTION: The tumor is a well delineated. nodular. necrotic. poorly differentiated carcinoma with bizarre nuclei. increased mitotic activity. There is very little tubular differentiation INTRAOPERATIVE CONSULTATION: RIGHT BREAST LUMPECTOMY: GROSS TUMOR PRESENT WITH CLOSEST MARGIN DEEP MEASURING 1.5 CMS TUMOR TISSUE PROVIDED TO TISSUE BANK COORDINATOR RESULTS GIVEN TO DR.  IN OPERATING ROOM AT PHOTO DOCUMENTATION Image Picture Copy Error Signed (signature on file) ** END OF REPORT * 1/313
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diff --git a/output/text/28917481-d22a-4553-bf4c-20dec98e74de.txt b/output/text/28917481-d22a-4553-bf4c-20dec98e74de.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fd6b8ed9b51fbc620615191547e95b1f738bdf78
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+
+--- Page 1 ---
+TCGA-BO-4693 FINAL DIAGNOSIS PARt 1: bONE, RIB, EXCISION: A. FIBROCArTILAgINOUS TISSUe WITH nO SPECIFIC pATHOLOgIC CHAnGES. B. frAGment Of bONe (grOSs eXAMInATIOn OnLy). Part 2: KIdney, Left, Radical nephrectomy - A.  RENAL CELL CARCINOMA, CONVENTIONAL (CLEAR CELL) TYPE WiTH SARCOMATOID FEATURES, LARGE AREAS OF NECROSIS AND.HEMORRHAGE (See synoptic). B. FUHRMAN NUCLEAR GRADE IS 4 of 4. C. THe GrEaTeSt DIAmETer Of THE NEOpLASm IS 13.0 cm.. RENAL SINUS FAT IS INVOLVED. BY CARCINOMA. E. THE NEOPLASM INVADES THROUGH THE RENAL CAPSULE, EXTENDS INTO THE PERIRENAL FAT AND IS LOCATED IN CLOSE PROXIMITY TO ADRENAL GLAND. NO INVASION OF THE RENAL VEIN IS IDENTIFIED. G. ANGIOLYMPHATIC INVASION IS IDENTIFIED. H. ALL SURGICAL MARGINS ARE FREE OF THE NEOPLASM. THE NON-NEOPLASTIC KIDNEY SHOWS CHANGES DUE TO PROXIMITY THE TUMOR. J. HISTOLOGICALLY UNREMARKABLE ADRENAL GLAND IS NOT INVOLVED BY CARCINOMA K. TNM STAGE: pT3a NO MX. PART 3: LYMPH NODES, PERIAORTIC, EXCISION: NO CARCINOMA SEEN IN FIVE LYMPH NODES EXAMINED (0/5)
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diff --git a/output/text/28a422d4-d62a-4a1c-9d33-6ec975080688.txt b/output/text/28a422d4-d62a-4a1c-9d33-6ec975080688.txt
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index 0000000000000000000000000000000000000000..ca3fd694683b79f8acaf1e22e074fe3acb9c7637
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+
+--- Page 1 ---
+UUID:ABE9C586-6C72-42F3-8007-22762DA9C7A9 TCGA-Lk-A4NZ-01A-PR Redacted FINAL DIAGNOSIS: Part 1: Lung, right Lower lObe, biopsy - BENIgn BRONcHIaL mUCOSA. Part 2: bone, third rib, Resection- A. SOft TISSUe WITH A DIffUSe mALIGnAnT MESOtheLiOmA, EPITheLIOID TyPE. B. UNREMARKABLE BONE AND BONE MARROW. PArTS 3 AND 4: PLERA, RIGHT, RESECTION - A.  DiffUSe mALIgnAnT mESOtheLIOmA, EpItheLIOId TYPE, EXTenDING InTO ADJACEnt LUNG PARENCHYMA (see comment). B.  PLEURAL HYALINE PLAQUE. COMMENT: The histomorphology of the tumor shows a diffuse mallgnant mesothelloma with a predominantly epithellold variant. However, a tubulopapillary pattern is focally seen. Addendum Probe: Dual Color Probee RESULTS : Fluorescence in situ hybridization studies performed on the malignant mesothelioma demonstrate 1 (1.6%) cells with homozygous loss and 10 (15.6%) of cells with hemizygous loss. The ratilo of p16 (9p21) to the centromere of chromosome 9 was 0.95. The targeted region (total 64 cells) is considered to be NEGAtivE for p16 (9p21) deletlon. Interpretation guldelines for 9p21 by FISH: Ratio of p16 to the centromere of chromosome 9: Normal Range Ratlo: 0.85-1.19  Normal % deletion: less than 20% Clinical studies Indicate diagnostic and prognostic significance of p16 deletion in malignant mesotheliomas. FISH analysls was manually performed and quantitatively assessed by analysis of a minlmum of 60 cells. Reference: Illel P, Ladanyi M, Rusch V, Zakowski M.The Use of CDKN2A Deletlon as a Dlagnostic Marker for Malignant Mesothelioma in Body Cavity Effusions. Cancer (Cancer Cytopathology), 99(1):Feb 25, 2003. Lopez-Rios F, Ladanyl M, et ai. Global Gene Expression Profiling of Pleural Mesothellomas:  Overexpression of Aurora Kinases and P16/CDKN2A Deletion as Prognostic Factors and Critical Evaluation of Microarray-Based Prognostic Prediction.Cancer Res 2006; 66 (6): March 15, 2006. Chlosea S, Krasinskas A, Cagle PT, Mitchell KA, Zander DS, Dacic S. Diagnostic importance of 9p21 homozygous deletion In malignant mesotheliomas. Mod Pathol. 2008 Jun;21(6):742-7. 1cs-0-3 Mesothelionn, dpi+huli'oid, N0s 9o5313 Srts : pleura, Nos c38.4
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diff --git a/output/text/28bb7e9c-adb5-48a8-b650-e0edade84bb9.txt b/output/text/28bb7e9c-adb5-48a8-b650-e0edade84bb9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c9c90273916931185456b8716bc1b271779dce80
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+FINAL DIAGNOSIS: Part 1: Lymph nODe, Right AxillA #1 SentineL, biOpsy -- A.: One (1) Lymph nODe POsiTIVe fOr metAstaTIC CArcinomA (1/1). B.  MEtastatic TumOr mEasureS 0.5 Cm. PARt 2: Lymph nODE, RIgHT AXILLA #2 SEntineL, BiOPSY - B METASTATIC FOCUS MEASURES 1.1 CM. C. EXTRACAPSULAR EXTENSION IS IDENTIFIED. PART 3: BREAST, RIGHJ, TOTaL MASteCTOMY - A MOLTIPLE FOCI OF INVASIVE DUCTAL CARCINOMA WITH APOCRINE FEATURES, NOTTINGHAM SCORE 8/9 (TuBuLeS - 2, nuCLEAr GraDe -- 3, MITOSES -3). B. THE LARGER iNVASIVE TUMOR MEASURES 2.4 CM, AND iS LOCATED AT 9:00 O'CLOCK POSITION. C. The Smaller invasive TumOr mEasures 1.1 Cm, And LOcAted at 12 O'clOck pOsitIOn. D. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 3, APOCRINE AND SOLID TYPES WITH COMEDO NECROSIS. E. DUCTAL CARCINOMA IN SITU CONSTITUTES 20% OF THE TOTAL TUMOR MASS AND iS PRESENT ADMIXED WITH AND AWAY FROM THE INVASIVE COMPONENT (UPPER OUTER QUADRANT). F. LYMPHOVASCULAR INVASION IS IDENTIFIED. G. ALL SURGICAL MARGINS OF RESECTION ARE FREE OF TUMOR. H.  Nipple is free of tumOr. I. SKiN IS NEGATIVE fOR TUMOR. J.  MICROCALCIFICATIONS ARE PRESENT IN ASSOCIATION WITH DCIS AND INVASIVE CARCINOMA. K. NON-NEOPLASTIC BREAST PARENCHYMA WITH FIBROCYSTIC CHANGES. L. ER POSiTIVE, PR POSITIVE, HER-2/NEU POSITIVE 3t Part 4: Lymph nodes, right axiLlary, Dissection -  One (1) Of Seventeen Lymph nOde pOsitive fOr metastatiC Carcinoma (1/17). A. B. focus Of metastatic Carcinoma measures 1.3 Cm. EXTRACAPSULAR EXTENSION IS iDENTIFiED. 1cs-0-3 Laoe oinupsis: SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST Cavcinom nfi/truh'ug ductd,nos 8500f3 LATErALITy: PROCEDUrE: Right Sin:bresf,Nos c50.9 3|r3/1 p LOCAtION: Modified radical mastectomy Upper outer quadrant SIZE OF TUMOR: Lower inner quadrant MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:  Maximum dimension invasive component: 2.4 cm TUMOR AGGREGATE SIZE: Yes TUMOR TYPE (invasive component): Sum of the sizes of multiple invasive tumors: 3.5 cm NOTTINGHAM SCORE: Ductal adenocarcinoma, NOS Nuclear grade: 3 Tubule formation: 2 UUID: B5ESA3B8-108E-47D3-99DA-EC7A64B5FA9C Mitotic activity score: 3 TCGA-BH-A0B7-01A-PR Redacted Total Nottingham score: 8 ANGIOLYMPHATIC INVASION: Nottingham grade (1, 2, 3): 3 Yes DERMAL LYMPHATIC INVASION: No CALCIFICATION: Yes, malignant zones Tumor type, in situ: Solid, Apocrine, DCIS admixed and outside of invasive carcinoma component, Ductal. SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:E carcinoma in situ, multifocal, Percent of tumor occupied by in situ component: 20 %. SURG MARGINS iNVOLVED BY IN SITU COMPONENT: No Criter PAgEt'S DISEASE OF nIPpLE: No LymPh nODeS POSITIVE: No LYMPH NODES EXAMINED: 3 METHOD(S) OF LyMPH NODE EXAMInATION: 19 SENTINEL NODE METASTASIS: H/E stain 3/13/11 ONLY KERATIN POSITIVE CELLS ARE PRESENT: Yes SIZE OF NODAL METASTASES: No LYMPH nODE METASTASIS(-ES) WITH EXTRACAPSULAR EXTENSION: Diameter of largest lymph node metastasis: 1.3 mm METASTASES TO IPSILATERAL INTERNAL MAMMARY LYMPH NODE (IF APPLiCABLE): Yes SKIN INVOLVED (ULCERATION): No NON-NEOPLASTIC BREAST TISSUE: FCD No t Stage, patholOgIC: N Stage, patholOgiC: pT2 m Stage, Pathologic: pN1a RAAV
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diff --git a/output/text/28cbbd8e-abc5-4bc8-a585-011d8f604ec0.txt b/output/text/28cbbd8e-abc5-4bc8-a585-011d8f604ec0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..216eb8415fcf6e67cc5216e97efeaf2519d00448
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+Final Diagnosis Mass, left kidney, wedge resection: Papillary renal cell carcinoma, 1.5 cm in greatest dimension.. Fuhrman nuclear grade I/IV. Tumor is limited to the wedge resection and the margins are free of involvement. Angiolymphatic invasion is not identified. AJCC Pathologic Stage T1, Nx Renal cyst: Benign cyst with scant epithelial lining and no evidence of clear. cells. Renal parenchyma underlying cyst wall shows sclerotic glomeruli.. Comment: The renal mass is small, 1.5 cm, and has a papillary appearance without. typical foam cells. Slides reviewed with Clinical Information Left renal mass/left renal cyst. Gross Description "A, Left kidney mass." The specimen consists of a previously sectioned, previously inked fragment of kidney on reconstruction measures 2 x 1.5 x 1.2 cm. On the cut surface is an exposed tan friable mass measuring approximate 1.5 cm. The adjacent renal parenchyma is tan-gray and up to 0.4 cm thick. "A1-A3," fragments, all.. "B, Cyst wall." The specimen consists of a brown-tan collapsed thin-walled cyst measuring 2.3 x 1.2 cm. The cyst wall is less than 0.2 cm thick. "B," fragments, all.
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diff --git a/output/text/28ccdb58-3ab8-4a4b-a1af-f91430ce2396.txt b/output/text/28ccdb58-3ab8-4a4b-a1af-f91430ce2396.txt
new file mode 100644
index 0000000000000000000000000000000000000000..52c8c46c2dc901d363af1ac065fb13ee8b27964d
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+Page 1 of 2 UUID:98C704DE-0914-49F1-80F9-36CFE52B8484 Patient:  TCGA-B6-A402-01A-PR Redacted AP Surgical Pathology: Surg Path CLINICAL HISTORY: Palpable 8:00 mass, rule out malignancy. If invasive carcinoma, please obtain ER, PR, EGFR, HER2/Neu by immunohistochemistry; for all 2+ IHC results please do Fish analysis. GROSS EXAMINATION: A. "usncb right breast, three cores, 8:00 region", received in formalin is a 2.1 x 0.2 x 0.1 cm aggregate of fibrofatty needle core tissue fragments are submitted entirely in a mesh bag in block Al.. 1cD-o-3 carcinornq,inF1Hghing ductg1 N0S MICROSCOPIC EXAMINATION: 8so0J3 Microscopic examination is performed. DIAGNOSIS: A. "USNCB RIGHT BREAST, THREE CORES, 8:OO REGION" (ULTRASOUND GUIDED NEEDLE CORE BIOPSY) : INVASIVE ADENOCARCINOMA OF THE BREAST. HISTOLOGIC TYPE: DUCTAL. NOTTINGHAM COMBINED HISTOLOGIC GRADE: 3 OF 3.S TUBULE FORMATION SCORE: 3. NUCLEAR PLEOMORPHISM SCORE: 3. MITOTIC RATE SCORE:  3. IN-SITU CARCINOMA: NOT IDENTIFIED. VASCULAR INVASION: ABSENT. CALCIFICATION: PRESENT. ESTROGEN/PROGESTERONE RECEPTOR, HER2/NEU, AND EGFR ANALYSIS: PENDING. PARAFFIN BLOCK NUMBER: A1. RESULTS WILL BE ISSUED IN AN ADDENDUM. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es).. Electronically signed:t ADDENDUM 1: Please see for results of supplementary tests. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es).. Electronically signed: Performed by: Attending MD: Ordering MD:
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diff --git a/output/text/292c3041-d2d5-4b23-9222-bb7603340009.txt b/output/text/292c3041-d2d5-4b23-9222-bb7603340009.txt
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index 0000000000000000000000000000000000000000..17abadcbec50ec47bcfa64e1be3c691f29f6f4bb
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+--- Page 1 ---
+Surgical Pathology Report Name: Case #: DOB: Collected: Gender: Received: MRN: Reported: Location: Copy To: Physician: Pathologic Interpretation: A. Sentinel node #1 CT41 left axllla: 1CD-0-3 - No carcinoma seen in one lymph node (0/1). Cavcnomr,nfiltratny oucto(, Nos 85oo]3 - Keratin immunohistochemistry pending. Ste busot NOs C50.9 3/13| B. Left axilla sentinel node #2 count  .. - No carcinoma seen in one lymph node (0/1). - Keratin immunohistochemistry pending. UUID:4A0524B4-2A0B-4442-91B6-0E2FEA90CBC6 TCGA-EW-A1PC-01A-PR Redacted c. Right axilla sentinel node #1 count - No carcinoma seen in one lymph node (0/1). - Keratin Immunohistochemistry pending. D. Left breast: - INFiLTRATING DUCTAL CARCINOMA, poorly differentiated, Nottingham grade 3 (3+3+3=9), 6.0 cm in greatest dimension. - The tumor Infiltrates the dermis. - Lymphovascular invasion is not Identified. - Margins free of tumor.. - See tumor summary. Tumor Summary (Invasive Carclnoma of the Breast) (D); Specimen Type: Partial breast Procedure: Total mastectomy (including nipple and skin) Lymph Node Sampling: Sentinel lymph node(s) Specimen Integrity: Single intact specimen (margins can be evaluated) Speclmen Laterallty: Left'. Tumor Size: Size of Largest Invaslve Carcinoma: Greatest dimenslon of largest focus of invasion: 6.0 cm Additlonal dimensions: 5.5 x 4.0 cm Tumor Focallty: Single focus of invasive carcinoma Macroscoplc and Microscopic Extent of Tumor: Skin: Invasive carcinoma directly invades into the dermis or epidermis without skin ulceration Skeletal Muscle: Skeletal muscle is present and is free of carcinoma Ductal Carcinoma in Situ: No DCIS is present Histologic Type of Invaslve Carcinoma: Invasive ductal carcinoma (no special typa or not otherwise specified) Histologlc Grade: Glandular (Acinar)/Tubular Differentiatlon: Score 3 Nuclear Pleomorphism: Score 3 Mitotic Count: Score 3 Overall Grade: Grade 3. Margins: Uninvolved by invasive carcinoma Distance from closest margin: 15 mm (inferior) Speclfy margins: Distance from posterlor margin: 20 mm Treatment Effect: Response to Presurgical Therapy: In the breast: No known presurgical therapy In the lymph nodes: No known presurgica! therapy Lymph-Vascular Invasion: Not Identified Dermal Lymph-Vascular Invasion: Not Identified Lymph Nodes: Number of sentinel lymph nodes examlned: 2 Total number of lymph nodes examined (sentinel and nonsentinel): 0 Number of lymph nodes with macrometastases: 0 Number of lymph nodes with micrometastases: 0
+
+--- Page 2 ---
+SURGICAL PATHOL Report Number of lymph nodes with isolated tumor celts: 0 Method of Evaluation of Sentinel Lymph Nodes: Hematoxylln and eosin (H&E), one level Immunohistochemistry pending  Pathologlc Staging (pTNM) Primary Tumor: pT3 Regional Lymph Nodes: Modifler: sn. Category: pN0 (pending immunohistochemistry) Distant Metastasls: Not applicable Ancillary Studles: Estrogen Receptor: Pending Progesterone Receptor: Pending Her2: Pending AJCC classification (7" ed) pT3 snN0 MX (pending ovaluatlon of keratin in sentinel nodes) E. Right breast: - DUCTAL CARCiNOMA IN SITU, intermediate grade (DIN2) with expansive necrosis, solid and cribriform types. - The largest focus is 3 mm, and it is present in 3/15 slldes. - Resection margins negative. - Proliferative fibrocystic changes including intraductal papilloma (5 mm), columnar cell changes without atypla, apocrine cell metaplasla, stromal fibrosis and microcyst formation. - See tumor summary. - Two fibroadenoma, largest 11 mm. Tumor Summary (DCIS QF THE BREA$T) (E): Speclmen Type: Total breast (including nipple and skin) Procedure: Total mastectomy (including nipple and skin) Lymph Node Sampling: Sentinel lymph node(s) Specimen Integrity: Single intact specimen (margins can be evaluated) Speclmen Laterallty: Right Tumor Size: Size of Largest Invaslve Carcinoma: Greatest dimension of largest focus of invaslon: 0.3 cm Number of blocks with DCis: 3  Number of blocks examlned: 15 Histologic Type: Ductal carcinoma in situ. Classified as Tis (DCiS) or Tis (Paget) Architectural Patterns: Cribriform Solld Nuclear Grade: Grade II (intermediate) Necrosis: Present, central (expansive *comedo" necrosis) Margins: Involved by DCIS Distance from closest margln: 2mm. Treatment Effect: Response to Presurgical Therapy: No known presurgical therapy Lymph Nodes: Number of sentinel Iymph nodes oxamined: 1 Total number of lymph nodes examined (sentine! and nonsentinel): 1 Number of iymph nodes with macrometastases: 0 Number of lymph nodes with mlcrometastases: 0 Number of lymph nodes with Isolated tumor celis: 0 Size of largest metastatic deposit: 0 Method of Evaluation of Sentinet Lymph Nodes: Hematoxylin and eosin (H&E), one level Immunohistochemlstry pending Pathologlc Staging (pTNM) Primary Tumor: pTis (DCIS) Reglonal Lymph Nodes: Modifler: sn Category: pN0 (pending immunohistochemistry) Distant Metastasis: Not applicable Anclllary Studles: Page 2 of 5
+
+--- Page 3 ---
+SURGICAL PATHOL Report Estrogen Receptor: Pending Progesterone Receptor: Pending. AJCC classiflcatlon (7th ed) pTis (DCIS) snN0 MX (pending evaluatlon of keratin in sentinel nodes). NOTE: Some inmunohistochemica) antbodies are ansiyte specic reagents (ASRs) validated by ou taboratory (Her ?, Paryo, H. pytoni, HBcore). These AsRs are cinically usetu ndicators that do not require FDA approval. These cones are used: 1D5=ER, PgR 636=PR, A4 Wih formalin or molocuia ixed, parafin embeddod tissue. Detection is by L$A8. The resulls are read by a pathologis! ss postive or nogative. 65=HER2,H-11=EGFR, CCH2/DDG9=CMV,F39.4.1=AR8nd HPV by 1SH.A#immunohistochemics/ stsins ar used As the attending pathologist, I attest that :() Examined the relevant. preparation(s) for the specimen(s): and (t) Rondered the diagnosis(es). Procedures/Addenda Addendum Date Ordered: Status:  Signed Out Date Complete: Date Reported: Addendum Diagnosis A. Sentinel Node #1, Left Axlia: Immunohistochemistry for keratin is negative.. Left Axilla Sentinel Node #2:. Immunohlstochemistry for keratin is negative.. Right Axilla Sentinel Node #1:. Immunohistochemistry for keratin is negative. D. Left Breast : The tumor cells are positive for ER and PR (focally). They are negative for HER2 (score O) by immunohistochemistry. Final AJCC staging: pT3,  snNO(i), Mn/a. E.  Right Breast:. The tumor cells are positive for ER and PR by immunohistochemistry. Final AJCC staging: pTis (DCIS) , snN0(1-), M n/a MD,PhD Intraoperative Consultation A.Sentinel node #1 CT41 left axilla touchprep: No carcinoma seen in frozen section and touch prep. Final diagnosis defer for permanent.. B. Left axilla sentinel node #2 count 31 touch prep:  No carcinoma seen In frozen section and touch prep. Final diagnosis defer for permanent. C. Right axilla sentinel node #1 count 79 Touch prep: No carcinoma seen in frozen section and touch prep. Final diagnosis defer for permanent. Page 3 of 5
+
+--- Page 4 ---
+SURGICAL PATHOL Report Clinical History: Not provlded Pre Operative Diagnosis: Not provided Speclmen(s) Received: A: Sentinel nods #1 CT41 left axilla touchprep B: Left axilla sentinel node #2 count 31 touch prep C: Right axilla sentinel node #1 count 79 Touch prep D: Left breast (1 stitich superior, 2 lateral, Fresh) E: Right breast (1 stitich superior, 2 lateral, Fresh) Gross Description: A. Received fresh and labeled *sentinel node #1  left axilla, touch prep" is a yellow-tan, irregular-shaped, soft tissue fragment measuring 1.5 x 1.5 x 1.0 cm. Specimen bisected and submitted in toto in one cassette for frozen section. 8. Received fresh and labeled *left axilla sentinel node #2 count 31, touch prep" is a yellow-tan, fibrofatty tissue measuring 1.5 x 1.0 x 1.0 cm. Specimen Is bisected and submitted in toto in one cassette for frozen section and touch prep. C. Received fresh and iabeled *right axilla sentinel node #1 count 79, touch prep" is a yellow-tan, irregular-shaped, soft tissue fragment measuring 2.0 x 1.0 x 1.0 cm. Specimen bisected and submitted in toto in one cassette for frozen section and touch prep. D. Recelved fresh and labeled *left breast (1 stitich superior, 2 lateral)' is a left radical modified mastectomy measuring 21.0 x 19.0 x 4.0 cm and weighs 750 grams. The skin is light tan, elllpse, measuring 21.0 x 16.0 cm. Areola is 8.0 cm in maximum diameter and nipple is impressed and very hard measuring 2.5 cm in maximum diameter. The specimen Is oriented with one stitch at superior and two stitches at lateral. The surgical margin Is inked in black. Sectioning reveals a yellow-gray, well defined, tumoral mass measuring 6.0 x 5.5 x 4.0 cm. This tumor is 60% necrotic with focal hemorrhage. No calcification is noted grossly. This tumor Is located beneath of nipple. The remainder of mammary tissue is yellow-white, fibrofatty tissue. No other lesions Is identified grossly. This tumor is located at less than 0.1 cm from superficial (skin nipple), at 1.5 cm from inferior surgical margin, at 2.0 cm from deep surgical margin and the rest of the surgical margins are away more than 4.0 cm from this tumor. The specimen is submitted in fifteen cassettes as follows: 1 Perpendicular section superior margin 2 Perpendicular section inferior margin 3 Perpendicular section medial margin 4 Perpendicular section lateral margin 5 Perpendicular section of nipple in relation with tumor 6 Perpendicular section deep margin 7 Tumor in relation with nipple and skin 8&9 Hemorrhagic and necrotic area 10-13 Tumor 14&15  Mammary tissue E. Received fresh and labeled *right breast (1 stitich superior, 2 lateral)" is a right radlcal modified mastectomy measuring 20.0 x 15.0 x 4.0 cm and weighs 522 grams. The skin is light tan ellipse measuring 16.0 x 14.0 cm. Areola measures 6.5 cm In maximum diameter. The nipple measures 1.5 cm in diameter. The specimen is oriented with one stitch at superior and two stitches at lateral. The resection margin is inked in black. Sectloning reveals gray-tan, fbrocystic area measuring 7.0 x 7.0 x 3.0 cm, located at 1.0 cm from inferior surgical margin, at 2.0 cm from medial margin, at 3.0 cm from lateral margin, at 3.5 cm from superior margin, at 0.5 cm from deep surgical margln and Immediately beneath the nipple. Deep fibrocystic area has multiple cysts up to 1.0 cm in maximum diameter. The cysts are filled by brown-tan chocolate and green tan puruient material. Remainder of mammary tissue is gray-tan, fibrofatty tissue, unremarkable grossly. No other suspicious lesions are Identified grossly. Submitted In fifteen cassettes as follows: 1 2 Perpendicular section superior margin Perpendicular section inferior margin 3 Perpendicular section medial margin 4 Perpendicular section lateral margin Page 4 of 5
+
+--- Page 5 ---
+SURGICAL PATHOL Report 5 Bisected of nipple 6 Perpendicular section deep margin. 7 Necrotic tissue 8 Hemorrhagic necrotic area with deep surgical margin 9-14 Fibrocystic and necrotic mammary tissue. 15 Unremarkable mammary tissue ICD-9(s): 174.8 233.0 t 3/1sf11] Page 5 of 5
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diff --git a/output/text/2936fb2e-5456-49e2-8ffd-2d67d36706af.txt b/output/text/2936fb2e-5456-49e2-8ffd-2d67d36706af.txt
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index 0000000000000000000000000000000000000000..fbf22fd437e607041c2bbfcd6662a6eea4f1971f
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+Icd-0-3 UUID:F489FC43-C5D4-42F0-8397-A115A9ACDB89 -A7GX-01Z-PR Coreriono, sanal cll CJromyshobe type 831713 SeL QKiduyNoS Surgical Pathology Report C649 Diagnosis: HI9/24lL3 Kidney, right, laparoscopic radical nephrectomy Histologic tumor type/subtype: renal cell carcinoma, chromophobe subtype, eosinophilic variant Sarcomatoid features: not identified Histologic grade (if applicable): 2 (of 4, Fuhrman classification) Tumor size (greatest dimension): 7.2 cm Tumor focality: unifocal Extent of tumor invasion (if present specify if macroscopic or microscopic): Extra-capsular invasion into perirenal adipose tissue: not identified Gerota' s fascia: n/a Renal sinus: not involved Major veins (renal vein or segmental branches, IVC): not involved Ureter: not involved Lymphatics: not involved Surgical margins: Extracapsular soft tissue margin: not involved Renal vein margin: not involved. Ureter margin: not involved Adrenal gland: not received. Lymph nodes: none received. Other significant findings: none. AJCC Stage: pT2a pNx pMx Clinical History: yo male with right renal mass..
+
+--- Page 2 ---
+Gross Description: Received is one appropriately labeled container, additionally labeled "right kidney." It consists of a radical nephrectomy specimen (17.1 x 7.7 x 6.8 cm) consisting of kidney (14.6 x 7.2 x 4.7 cm, 427 gram). The upper pole has a 7.2 x 7.2 x 7.0 cm well circumscribed soft, pink/tan solid mass with focal hemorrhage and necrosis (20%). The mass expands the capsule, does not go through it, and is 0.4 cm from the perinephric adipose tissue margin (inked blue). The mass is 1.5 cm from the renal sinus The renal vein is free of mass. The uninvolved cortex medulla is well demarcated, red/brown without additional masses. No hilar lymph node candidates are identified. Adrenal gland is absent. Block summary: A1 - ureter, renal vein and artery margins, en face. A2 - renal sinus (perpendicular) A3,A4 - perpendicular of mass closest to the perinephric adipose tissue margin A5-A7 - additional sections of mass A8 - normal kidney from inferior pole Light Microscopy: Light microscopic examination is performed by Dr.. Sections show irregular nests of eosinophilic cells with punched out perinuclear clearing. By H & E alone, the differential diagnosis includes eosinophilic variant of chromophobe carcinoma, as well as granular variant of clear cell carcinoma. To clarify lineage, immunostains and Hale' s colloidal iron stain were performed, and show reactivity for CK7 and Hale' s colloidal iron, with no reactivity for RCc. The immunophenotype supports the above diagnosis.
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diff --git a/output/text/295011cf-a472-448e-b287-aa7a96346314.txt b/output/text/295011cf-a472-448e-b287-aa7a96346314.txt
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index 0000000000000000000000000000000000000000..e1eada0d91a0668408189e595a9acf3c48552e54
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+
+--- Page 1 ---
+Patient Name Accession #: Med. Rec. #: Date of Procedure: DOB: Date of Receipt: Gender: Date of Report: Ref. Physician: Account #: Patient Address: Billing Typo: Additional Copy to Ref. Source. Clinical Diaanosis & History: h left renal mass; s/p left nephrectomy and lymph node dissection.. Specimens Submitted: 2: SP: Ureter, segment of distal left; excisic 3: SP:Lymph nodes, para-aortic and preaortic; excision. 4: SP:tymph nodes, left common iliac:excision 5: SP:Lymph nodes, interaortocaval: excisior DIAGNOSIS: 1.  SP: Kldney and adrenal gland, left; radical nephrecton. Tumor Type: Renal cell carcinoma - Papillary lypo type2 Tumor Size: Greatest diameter is 5.8 cm. Local Invasion (for renal cortical types): Involves renal sinus fat Renal Vein Invasion: Not identified Small vesset angiolymphatic invasion is present. Surgical Margins: Free of tumor Non-Neoplastic Kidney: Mulliple benign corticat cysts Adrenal Gland: Not involved Lymph Nodes: Not identified Staging for renal cell carcinoma/oncocytoma:  pT3a Tumor invades the adrenal gland or perinephric tissues but not beyond Gerota's fascia SP: Ureter, segment of distal left; excision 2. Benign segment of ureter. Page 1 0f 4
+
+--- Page 2 ---
+3. SP:Lymph nodes, para-aortic and preaortic; oxcisior Lymph Nodes. Number of nodes examined:9. Number of metastatic nodes:1 The largest metastatic node is 0.6cm.  Perinodal (extracapsular) extension identified Two other separate nodules of lumor, the larger measuring 5.5 cm in diameter, are identified. Their representing Jymph nodes conpletely replaced by tumor cannot be excluded.. 4. SP:Lymph nodes, left common illac;excislon:. Lymph Nodes: Not involved. Number of nodes examined:6 5.  SP:Lymph nodes, interaortocaval; excislor Lymph Nodes: Not involved. Number of nodes examined.9 TATTEST THAT THE ASOVE OIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (ANDIOR OTHER MATERIAL). AND THAT I HAVE REVIEWED AND APPROVEO THIS REPORT Special Studies: Result Special Stain Comment RECUT RECUT RECUT RECUT RECUT Gross Description:. 1). The specimen is received fresh labeled "lelt kidney and adrenal gland' and consisls of a kidney with attached ureter, renal vessels and perinephric fat weighing 370 g in total. The kidney measures 11.5 x 6 x 4 cm.The atlached ureter measures 9.5 cm. in length and 0.5 cm in diameter. The attached renal vein measures 1.5 cm in length and 0.8 cm in diameter. The renal vessels and ureler margins are grossly unremarkable.. An adrenal gland is idenlified measuring 4 x 1.5 x 1 .2 cm. The kidney is inked. black and bivalved to reveal a tumor mass located in the upper pole measuring 5.8 x 4.5 x 3 cm. The mass on sectioning has a. Iobulated appearance. variegated cut surface showing tan-yellow areas admixed with areas of hemorrhage and foci of necrosis.. Grossly it is confined within the kidney and does no! exiend beyond the capsule. In the mid aspect of the kidney, and 1 cm away. from the tumor mass is a serous fluid-filled cyst, measuring 5 x 5 x 4 cm.. The cyst wall is smooth. Sections through the. remainder of the kidney reveal a pink brown parenchyma, with a well-defined corticomedullary junction. The cortex measures 0.8 cm and the calyces appear normal. No lymph nodos are identified in the perinephric fat. The specimen is photographed.. Representative sections are submitled for TPS and for permanent sections.. Summary of sections: FSC - frozen section control UVM -- ureteral and vessel morgins. TC- tumor in relation to kidney capsule  Paga 2 0f 4
+
+--- Page 3 ---
+THF-- hilar fat, closest to tumor. TSF -- tumor with sinus fat TK -- tumor with adjacent kidney. TP - tumor and renal pelvis C- cyst K -- representative sections kidney. AD -- adrenal gland 2)The specimen is received in formalin, labeled "Segment distal left ureter'.  It consists a of a segment of pink tubular tissue measuring 2.1 cm in length with a diameter of 0.3 cm. A stapled end is noted. The specimen is inked black. It is otherwise. grossly unremarkable.The specimen is totally ambedded. Summary of sections:. SM-shaved stapted margin R-remainder 3).  The specimen is received in formalin, labeled "para-aortic and pre-aortic lymph nodes", and consisls of three pieces of fally. tissue measuring 7.5 x 5 x 2.5 cm in aggregale. On sectioning, there is a soft tan nodule measuring 4 x 2. 1.5 cm, which on sectioning has areas of necrosis. There is a second 5.5 x 3 x 2.5 cm nodule that on sectioning shows lan yellow areas. In addition, there are smaller nodules measuring from 0.5 to 1 cm in greatest dimension. The small nodules are entirely submitted. Summary of seclions:. L1- lymph node. 5.5 cm, representalively. L2-lymph node, 4 cm representatively. LNs-smaller nodes 4) The specimen is received in formalin, labeled *Left common iliac lymph nodes". It consisls of multiple palpable lymph nodes ranging in size from 0.5 to 1.4 cm In greatest dimension. All possible nodal tissue is totally embedded in two casselles.. Summary of sections: LN-Jymph nodes 5) The specimen is received in formalin, fabeled Inter-aortocaval nodes". It consists of multiple small lymph nodes encased in. fat ranging in size from 0.4 to 0.8 cn in greatest dimension. All possible nodal tissue is totally embedded in three cassetles. Summary of seclions: LN-lymph nodes. Summary of Sectlons: Part 1: SP: Kidney and adrenal gland, left; radical nephrectomj Block Sect. Site PCs 1 AD 1 2 c 3 1 FSC *** 1 3 TC 3 1 THF 1 1 TK 1 1 TP 1 TSF 1 UVM 3 Part 2: SP: Ureter, segment of dista! left; excis! Page 3 of 4
+
+--- Page 4 ---
+Block Soct. Site PCs 1 R 3 1 SM Part 3:  SP:tymph nodes, para-aortic and preaortic: excislon Block Sect. Site PCs 1 l1 1 1 L2 1 3 LNs 7 Part 4:  SP:Lymph nodes, left common Iliac;excision Block Sect. Site PCs 2 LN 5 Part 5:  SP:Lymph nodes, Interaortocaval; excisio Block Sect. Site PCs 3 LN 7 Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consullation. 1) FROZEN SECTION DIAGNOSIS: RENAL CELL CARCINOMA WITH PAPILLARY FEATURES PERMANENT DIAGNOSIS: SAME Poge 4 of 4 END OF REPORT
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diff --git a/output/text/2982a18c-6710-4b0b-89f9-fd49a1ee1f25.txt b/output/text/2982a18c-6710-4b0b-89f9-fd49a1ee1f25.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3432112ad2fc7ac5192454ac36e472a002240e09
--- /dev/null
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+
+--- Page 1 ---
+1cs-O-3 Cascmvmn vfImuf7nq duct,N0s 85cc|3 UUID: 52D7E980-806C-499D-9DB9-40E1D651D9EB c5o.9 hw519/4 Site: breast, Nos TCGA-D8-A27H-01A-PR Redacted page 1 / 1 ncer Pathology copy No. 5 Date: Examination: Intraoperative examination. Internal invoice No.. Cost of diagnostic procedure Examination No.: Patient: XXX PESEL: XXX Age: Gender: F Unit in charge: Physician in charge:. Material collected on: Material received on: : Expected time of examination: 20 minutes (from receipt of material) Clinica! diagnosis: Suspected cancer of the right breast, tumour on the boundary of upper quadrants. Examination performed on: Intraoperative examinatior resus Carcinoma invasivum, 3 cm in diameter, mammae dextrae.. Final diagnosis to be given after the analysis of paraffin specimens. Compliance validated by: Examination performed on Immunohistochemical examination result: No estrogen receptors detected in neoplastic cell nuclei. No progesterone receptors detected in neoplastic cell nuclei. HER2 protein stained with HercepTestTM by DAkO. Negative reaction in invasive carcinoma cells (Score =0) dr Compliance validated by: Examination performed on: Macroscopic description: Surgical specimen sized 6 x 5 x 4 cm. Tumour sized 3 x 2.5 x 3.3 cm found in the cross section. Histopathological Diagnosis: Carcinoma ductale invasivum. invasive ductal carcinoma of the right breast. tHG3 (3 + 3 + 3: 50 mitoses/10 HPF, visual area 0,55 mm), pT2. Tumour reaching the incision line. Compliance validated by:
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diff --git a/output/text/299a1ff8-3075-4d73-a406-3d9ff97c1821.txt b/output/text/299a1ff8-3075-4d73-a406-3d9ff97c1821.txt
new file mode 100644
index 0000000000000000000000000000000000000000..844641f4f201ba06692617f94051d8dd4b00618c
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+
+--- Page 1 ---
+ SURGICAL PATHOLOGY REPORT * Addendum  Clinical Diagnosis & History: Sigmoid colon cancer. Specimens Submitted: 1: SP: Sigmoid colon 2: SP: Distal margin 3: SP:Proximal margin DIAGNOSIS: 1. LARGE BOWEL, SIGMOID; RESECTION: - INVASIVE ADENOCARCINOMA, MODERATELY DIFFERENTIATED. TUMOR LOCATION: SIGMOID. TUMOR SIZE: LENGTH IS 5.3 CM, WIDTH IS 5.5 CM AND MAXIMAL THICKNESS IS 1.1 CM. GROSS CONFIGURATION: ULCERATING INFILTRATIVE. PREEXISTING POLYP (AT THE SITE OF THE CARCINOMA) : NOT IDENTIFIED. TUMOR INVASION: INVASION INTO SUBSEROSA GROSS TUMOR PERFORATION: NOT IDENTIFIED. SEROSAL INVOLVEMENT: NOT IDENTIFIED. EXTRAMURAL VENOUS INVASION IS IDENTIFIED PERINEURAL INVASION IS IDENTIFIEDS SURGICAL MARGINS: FREE OF TUMOR.S POLYPS (AWAY FROM THE CARCINOMA) : NOT IDENTIFIED. NON-NEOPLASTIC BOWEL: MELANOSIS COLI. THE PATHOLOGIC STAGE IS (AJCC 2002): pT3 LYMPH NODES: THE LYMPH NODE STATUS IS AS FOLLOWS (EXPRESSED AS THE NUMBER OF METASTATIC NODES IN RELATION TO THE TOTAL NUMBER OF NODES EXAMINED: 0/14 (PEDICLE 1: 0/12, PEDICLE 2: 0/2). THE PATHOLOGIC STAGE IS (AJCC 2002): pNO THE RESULTS OF IMMUNOHISTOCHEMICAL STAINS FOR MISMATCH REPAIR PROTEINS WILL BE REPORTED IN AN ADDENDUM. 2. COLON, DISTAL MARGIN; EXCISION:  BENIGN SEGMENT OF COLON WITH MELANOSIS COLI 3. COLON, PROXIMAL MARGIN; EXCISION:  BENIGN SEGMENT OF COLON WITH MELANOSIS COLI. ** Continued on next page **
+
+--- Page 2 ---
+ Page 2 of 4 I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Gross Description: 1.) The specimen is received fresh and is labeled "Sigmoid colon". It consists of a 18.2 cm in length and a 5.5 cm in circumference of rectosigmoid colon. The serosa is glistening, smooth, tan-pink. The serosal surface is inked black and the specimen is opened to reveal a 5.3 (l) x 5.5 (w) cm, well-circumscribed, centrally cavitated and necrotic, serpiginous bordered, sessile mass, located 9.5 cm from the (probable) distal margin, occupying the full circumference of the lumen (designated Mass #1).  Serial sectioning reveals Mass #1 to invade through the muscularis into the ricolonic fat, to a depth of cm, which is  2.8 cm from the closest radial margin. In addition, 1.1 cm distal to Mass #l, is a 0.4 (l) x 0.4 (w), well-circumscribed, smooth, homogenous tan nodule, located 3.9 cm away. from the distal margin (designated Nodule #1). Sectioning reveals Nodule #1 to remain confined to the mucosa. The remaining mucosa is unremarkable. The specimen is submitted for lymph node dissection. Pericolic and peri-rectal adipose tissue is thoroughly examined for lymph nodes, and all possible nodes are submitted. Representative sections are submitted. Tps is submitted for Mass #l.. Summary of sections:. PM (probable) proximal margin DM (probable) distal margin RM -- radial margin M1 Mass #1 N1 -- Nodule #1 M1N1 Mass #1 and Nodule #1  -- uninvolved mucosa P1 pedicle one lymph nodes BP1  bisected pedicle one lymph nodes P2pedicle two lymph nodes BP2bisected pedicle two lymph nodes 2). The specimen is received in formalin, labeled "Distal margin" and consists of a ring of pink tan soft tissue measuring 2 x 1.8 x 1 cm.. Multiple sutures and staples are attached.  The mucosal surface is pink tan and focally hemorrhagic. The sutures and staples are removed and the soft tissue is entirely submitted. Summary of sections: Uundesignated ** Continued on next page **
+
+--- Page 3 ---
+Page 3 of 4 3). The specimen is received in formalin, labeled "proximal margin" and consists of a silver metal anastomotic pin measuring 7.5 x 2.8 x 1.5 cm. At the center of the pin, a white plastic piece is noted. A ring of pink tan soft tissue is attached measuring 1.5 x 1 cm. The mucosal surface is pink tan and focally hemorrhagic and the serosal surface is pink tan and smooth Several sutures and staples are noted. The sutures and staples are removed and the soft tissue is entirely submitted. Summary of sections: U--undesignated Summary of Sections: Part 1: SP: Sigmoid colon (nyt) Block Sect. Site pCs 2 bp1 4 1 DM 3 5 M1 5 1 M1N1 1 1 N1 1 4 p1 12 3 p2 3 1 PM 4 RM 1 1 U 2 Part 2: SP: Distal margin (nyt) Block Sect. site PCs U 1 Part 3: SP:Proximal margin (nyt) Block Sect.  Site pCs 1 U 1 Addendum Diagnosis Part 1. Results of immunohistochemical staining for DNA mismatch repair proteins MLH1: Staining present in tumor ** Continued on next page **
+
+--- Page 4 ---
+MSH2 : Staining present  in tumor MSH6: Staining present in tumor PMS2 : Staining present in tumor Conclusion: Immunohistochemical staining for the tested DNA mismatch repair proteins is retained in the tumor. Some of the immunohistochemistry and Ish tests were developed and their performance characteristics were determined by the Department of Pathology. They have not been cleared or approved by the Us Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not under the Clinical Laboratory. Improvement Amendments of ** End of Report 
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diff --git a/output/text/29aced4c-d606-4d1b-9ba2-2f42ed62b6f1.txt b/output/text/29aced4c-d606-4d1b-9ba2-2f42ed62b6f1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..55323d3e41865a0f8419fd0f8d93852d9f2766d4
--- /dev/null
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+
+--- Page 1 ---
+SPECIMENS: A. PERITONEAL IMPLANT  B. SMALL BOWEL IMPLANT C. SIGMOID COLON D. RECTAL DONUT E. COLON DONUT DIAGNOSIS: A. PERITONEAL IMPLANT: - POSITIVE FOR ADENOCARCINOMA B. SMALL BOWEL IMPLANT: - POSITIVE FOR ADENOCARCINOMA. C. SIGMOID COLON, RESECTION:  CIRCUMFERENTIAL EXOPHYTIC ULCERATED MODERATELY DIFFERENTIATED INVASIVE ADENOCARCINOMA OF SIGMOID COLON WITH FULL MUSCLE WALL THICKNESS INVASION, EXTENSION TO SUBSEROSAL FAT WITH METASTASIS TO ONE OUT OF TWENTY FIVE LYMPH NODES AND WITH PERICOLIC FAT TUMOR IMPLANTS.(1/25) - SIZE OF TUMOR 5 X 3.5 X 1.6 CM. - MARGINS OF RESECTION- NEGATIVE FOR TUMOR. D. RECTAL DONUT: - RING SEGMENT OF COLONIC TISSUE-- NEGATIVE FOR TUMOR. E. COLON DONUT: - RING SEGMENT OF COLONIC TISSUE, NEGATIVE FOR TUMOR. COLORECTAL CANCER TEMPLATE Specimen Type: Sigmoidectomy Tumor Site:  Sigmoid colon Tumor Configuration: Exophytic (polypoid), infiltrative, ulcerating. Tumor Size: 5.0 x 3.5 x 1.6 cm Histologic Type: adenocarcinoma Histologic Grade: G2: Moderately differentiated Extent of Invasion: Lamina propria, submucosa, muscularis propria Margins:  Margins uninvolved by invasive carcinoma (proximal, distal, radial)  Venous/Lymphatic Invasion: Present Perineural Invasion:. Absent Additional Pathologic Findings:. tubular adenoma Extent of Resection: R0: Complete resection with grossly and. microscopically negative margins Lymph Nodes: Positive (1/25) Implants: Present EGFR Expression: na Pathologic Stage: pT3 N1 Mx  NOTE: Nodular focus of tumor implant seen in slide #C13 and #C16. Small focus of tubular adenoma in association with carcinoma seen in slide labelled#C 31. SPECIMEN(S): A. PERITONEAL IMPLANT B. SMALL BOWEL IMPLANT C. SIGMOID COLON D. RECTAL DONUT E. COLON DONUT CLINICAL HISTORY:  with carcinoma sigmoid colon
+
+--- Page 2 ---
+INTRAOPERATIVE CONSULTATION DIAGNOSIS: FSA: Soft tissue, peritoneal implant, bx: - Metastatic poorly differentiated adenocarcinoma by GROSS DESCRIPTION: A. PERITONEAL IMPLANT: Received fresh is a 1x0.8x0.7 cm. tan-red piece of tissue with tan-white solid cut surface. Half is submitted for frozen section and the other half is submitted in cassette A2. B. SMALL BOWEL IMPLANT: Received fresh is one fragment of tan-pink soft tissue measuring 1x0.5x0.4 cm. The specimen is submitted in toto in one cassette.. C. SIGMOID COLON:RESECTION Received in fresh state is a resected segment of sigmoid colon with attached indurated pericolic fat. measuring 17 cm in length. There is a firm, palpable mass with overlying indurated mesocolic fat in the mid segment of the specimen, which when opened shows an ulcerated exophytic circumferential tumor situated 10.5 cm and 9.0 cm from margins of resection. The tumor measures 5 x 3.5 x 1.6 cm. Cut. section shows a tan dirty white granular firm surface infiltrating the full thickness of the colonic wall with extension into the subjacent adipose tissue. The remainder of the colonic mucosa shows prominent mucosal fold with hyperemia. Approximately 25 lymph nodes are identified ranging in size from 0.1 to 0.8 cm in diameter  Multiple sections are submitted as follows: C1-C5: en bloc section of tumor with pericolic fat C6-C7: sections from the resecte margins C8-10- sections form tumor areathe colonic wall and area of tumor C11-C24: sections from lymph nodes. C25-C31: additional more sections tumor and adjacent areas. D. RECTAL DONUT: Received in formalin is a piece of donut tissue measuring 2.5x1.8x0.8 cm. Specimen is bisected and. submitted in toto in cassette D1 and D2. E. COLON DONUT: Received in formalin is a donut shaped tissue measuring 2.0x1.7x0.6 cm. The specimen is bisected and submitted in toto in cassette E1 and E2. Also included is a n umbrella shaped like metallic object ,(rod measures 3.Ocm.in length and head.  measures 3.0 cm in diameter.. Gross exam only.
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diff --git a/output/text/29d60019-7f59-4b9b-8a7d-27927e29b9d4.txt b/output/text/29d60019-7f59-4b9b-8a7d-27927e29b9d4.txt
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index 0000000000000000000000000000000000000000..88c77d959377e6f3de86a1bde463db7f419b52ac
--- /dev/null
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+
+--- Page 1 ---
+FINAL DIAGNOSIS: Breast, Left, modified radical mastectomy - A.  iNVASiVE LOBULAR.CArcinoMA, nOTTinGhAm GRADe 2 (TUbULAR fORmATIOn 3, nUCLEAR ATyPIA 2, MitOtic ActivIty 1; tOtal ScOrE 6/9). B. THe InVASIVE TUmOR INVOLVES ALL fOUR BREASt QUADRANTS, MEASURinG 11.0 Cm iN LARGEST DImeNSIOn (GROSS MEASUREMeNT). C. THe INVASIVe tUmOR fOCALLy POsiTive in Deep mArgIn in LOWer-iNneR QUaDRant (SLiDE r). D.  MICROCALCIFICATIONS ASSOCIATED WITH INVASIVE CARCINOMA. E. LOBULAR CArcInOmA in-SiTU, nUCLEAR GRADE 2, ADmIXED AnD AWAy FrOm InVASIVE COMPOneNt. F. LOBULAR CARCINOMA IN-SITU IS 1.5 CM TO THE NIPPLE SURFACE. G. PApillOmA, FibrOcystIC ChangE, And COlumnaR CELl ChangE. H. Eight Of SEVenteEn Lymph nODeS, POsiTIve fOr metAstaTIC LOBulAR CArcinOmA (8/17). METASTATIC TUMOR MEASURES 1.5 CM IN LARGEST DIMENSION AND SHOWS EXTRACAPiSULAR I. EXTENSION. J. BIOPSY SITE CHANGES. K.  INVASIVE TUMOR IS ER POSITIVE, PR NEGATIVE, AND HER-2/NEU NEGATIVE (CAAg MR) CASE SYNOPSIS: SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST 1Cg-0-3 LATERALITy: PROCEDURE: Left Cavcm 0ma,nfilfnsHxy 1obuloN,nos 8520f3 LOCATIOn: Modified radical mastectomy Upper outer quadrant Sih:brm+,Nos c50.9 3/3f pw Upper inner quadrant Lower outer quadrant. SIZE OF TUMOR: Lower inner quadrant Maximum dimension invasive component: 11 cm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: TUMOR TYPE (invasive component): No HiSTOLOGIC TYPE: Infiltrating lobular carcinoma Classical ANGIOLYMPHATIC INVASION: DERMAL LYMPHATIC INVASION: Yes CALCIFICATION: No Yes, malignant zones. TumOR TyPE, IN SITU: SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: LCIS LymPh NODeS EXAMiNED: Yes, foca! METHOD(S) OF LyMPH NODE EXAMINATION: 17 H/E stain SENTINEL NODE METASTASIS: Yes t Stage, pathologic: N STagE, PAThOLOgIC: pT3 m Stage, pathologiC: pN2a EstrOgen receptOrS: pMX PROGESTERONE RECEPTORS: positive HER2/NEU: negative zero or 1+ UUID:F13CE7B3-F275-4EEE-90A3-1188892FA431 TCGA-BH-A0HP-01A-PR Redacted IPAA Discrepa
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diff --git a/output/text/2a0c09c8-6cc9-4538-9d65-7fc23bd67834.txt b/output/text/2a0c09c8-6cc9-4538-9d65-7fc23bd67834.txt
new file mode 100644
index 0000000000000000000000000000000000000000..240b712cd37574c193d7d0782540337b33602f16
--- /dev/null
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+--- Page 1 ---
+Diagnosis (diagnoses): Resected ileocolic sample with a moderately differentiated adenocarcinoma of the colorectal type, located in the cecum, max. 4 cm in diameter, with infiltration of the pericecal fatty tissue. Circumscribed fibrinous serositis in the area of the tumor. Stage of tumor: pT3, pN0 (0/36), pMX; G2, L0, V0, R0
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diff --git a/output/text/2a1b8aec-0e2f-4e87-8af2-e24c4446a0fe.txt b/output/text/2a1b8aec-0e2f-4e87-8af2-e24c4446a0fe.txt
new file mode 100644
index 0000000000000000000000000000000000000000..25c8960dc0c9732dcee2a9f3495d60b94fde3540
--- /dev/null
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+
+--- Page 1 ---
+PATHOLOGIC DIAGNOSIS: A.KIDNEY,RIGHT,NEPHRECTOMY: RENAL CELL CARCINOMA,CHROMOPHOBE TYPE (2.8 Cm). Tumor is well circumscribed and confined to the renal parenchyma. Ureter, artery, vein margins are not involved (levels examined.) Hale's colloidal iron stain is positive in many tumor cells. AJcC stage (6th edition): T1a NX MX B. ELEVENTH RIB: Normocellular bone marrow with maturing trilineage hematopoiesis. C.HILAR LYMPH NODE: One (l) lymph node with no significant pathologic change.. CLINICAL DATA: History: Not provided. Operation: Right radical nephrectomy.. Operative Findings: None given. Clinical Diagnosis: Right upper pole renal mass. TISSUE SUBMITTED: A/1. Right kidney B/2. Eleventh rib. C/3. Hilar lymph nodes right side.. GROSS DESCRIPTION: The specimen is received fresh, in three parts, each labeled with the patient?s name and unit number.. Part A, labeled "#1. Right kidney", consists of a 132 gm, right kidney with scant amount of fat attached to the kidney and no identifiable adrenal. The. kidney (10.5 x 5.5 x 3.4 cm) has an attached artery (1.5 cm in length x 0.3 cm in diameter) and attached vein 0.7 cm in length x 0.5 cm in diameter), and inferior second branch vein (1.2 cm in length x 0.2 cm in diameter), and attached 4.5 cm segment of ureter (0.2 cm in diameter):  The mid portion of the kidney contains a mass in the renal parenchyma, which bulges into the renal. sinus (2.8 x 2.5 x 2.5 cm).  We marked the surface with black ink. Cut surfaces show soft dark tan/brown mottled tumor, which abuts the capsule, protrudes into the hilum and pushed but does not appear to involve the collecting structures in the pelvis. The lumen of renal vein is without obvious tumor thrombus.*  The renal parenchyma around the well-circumscribed tumor is compressed and pale and has the appearance of renal papillae distorted by the mass.  The cortical medullary junctions are well defined.. The cortexes are of the expected thickness, firm and light brown...  The capsule strips with. ease from the surface of the kidney except in the area of the tumor where it is firmly adherent (inked surface). Tumor is taken for cytogenetics and electron microscopy. Normal tissue is taken for electron microscopy and immunofluorescences. Representative sections tumor and normal are submitted to tissue bank. The specimen is photographed. Lymph nodes are not grossly obvious in the fat. Micro Al: Margins of vein artery and ureter, 3 frags,. Micro A2: Tumor with adjacent collecting system, 1 fra. Page: 1 of 3
+
+--- Page 2 ---
+Printed: 11/28/2005 10:40 Page: 3 of 3
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diff --git a/output/text/2a1c84c1-595f-426b-9dc1-2225362c2292.txt b/output/text/2a1c84c1-595f-426b-9dc1-2225362c2292.txt
new file mode 100644
index 0000000000000000000000000000000000000000..de6a31cfeccbf9706d858c98a6c57b4d66527a96
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+
+--- Page 1 ---
+1cd-0-3 Carain oma, nifiltrating ouct, N0S 850o|3 12810 Path Site Ws: 5resst cntral prton c 50.1 CQcF Srh: brsst,N05 C50.9 TSS. SPECIMENS: A. SLN #1 B. SLN #2 C. LEft BrEAST D. SLN #3 UUID:9ECD3DA1-25A4-4325-9B3B-6D7C12283C37 E. UPpEr OuTEr QUANDrAnt LEft BREAST TCGA-E2-A14W-01A-PR F. SLN #4 Redacted G. iNFERIOR MEDIAL LEFT BREAST MARGIN SPECIMEN(S): A. SLN #1 B. SLN #2 C. LEFT BREAST D. SLN #3 E. UPPER OUTER QUANDRANT LEFT BREAST F. SLN #4 G. INFERIOR MEDIAL LEFT BREAST MARGIN INTRAOPERATIVE CONSULTATION DIAGNOSIS: TPA/TPB - SLN #1/SLN #2: Negative for tumor cells TPD/TPF - SLN #3/SL N #4: Negative for tumor. Called by Dr to Dr. at 1A,B. Dand F C - left breast: (gross exam only) 2.5 x 2 x 1.5 cm tumor located 1.2 cm from the closest/deep margin; tumor extends to the nipple and areola, called by Dr. to Dr. at GROSS DESCRIPTION: A. SLN #1 Received fresh is a tiny piece of lymphoid tissue within fibroadipose tissue, 0.4 x 0.2 x 0.2 cm. A touch prep is performed; submitted entirely in cassette A1. B. SLN #2 Received fresh is a piece of lymphoid tissue within fibroadipose tissue, 0.4 x 0.2 x 0.2 cm. A touch prep is performed; submitted entirely in cassette B1. C. LEft BREAST, STiTCh At AXIlLARy TAIL Received fresh labeled with the patient's identification and "left breast, stitch in axillary tait" is an oriented 392g, 20 x 14.5 x 2 cm mastectomy with 11.5 x 5.2 skin ellipse and 1.6cm inverted and ulcerated nipple. Ink code: Anterior/superior-blue, anterior/inferior-orange, posterior-black. The specimen is serially sectioned into 18 slices from medial to lateral with the nipple in slice 5 revealing a 2.5 x 2 x 1.5 cm white-tan firm well-circumscribed mass  beneath the nipple, present in slices 5 to 7 that is 1.2 cm from the deep margin. A gross diagnosis was conveyed to OR and tissue is procured. Representatively submitted: C1-C2: slice 5, mass and extension to nipple C3: slice 5, mass and deep margin C4: slice 6, superior posterior mass C5: slice 6, anterior inferior mass C6: slice 6, inferior posterior mass C7: slice 7, mass and normal appearing parenchyma. C8: slice 8, normal appearing parenchyma adjacent to mass C9: slice 3, upper inner quadrant C10: slice 9, upper outer quadrant C11: slice 10, lower outer quadrant. C12: slice 4, lower inner quadrant C13: skin C14-C17: nipple C18: 1 axillary lymph node D. SLN #3  Received fresh is a lymph node, 0.3 x 0.3 x 0.2 cm. A touch prep is performed and the lymph node is submitted entirely for cassette D1. E. UPPER OUTER QUADRANT LEFT BREAST; STITCH AT NEW UPPER OUTER MARGIN Received fresh labeled with the patient's identification and "upper outer quadrant left breast; stitch at new upper outer margin" is an oriented 37g, 9 x 6.3 x 0.8 cm fibrofatty tissue. Final margin is inked black. Serial sectioning reveals no discrete lesions. Representatively submitted in cassettes E1-E6.. F. SLN #4 Received fresh is a lymph node, 0.3 x 0.3 x 0.2 cm. A touch prep is performed; submitted entirely in cassette F1. G. INFERIOR MEDIAL BREAST-LEFT; STITCH AT DEEP MARGIN
+
+--- Page 2 ---
+Received fresh labeled with the patient's identification and "inferior medial breast-left; stitch at deep margin" is an oriented 3g, 4.1 x 2.5 x 0.6 cm fibrofatty tissue. Final margin is inked black. Serial sectioning reveals no discrete lesions. Entirely submitted in cassettes G1-G4. DIAGNOSIS: A. SENTINEL LYMPH NODE #1, LEFT AXILLA, BIOPSY: - ONE LYMPH NODE, NO TUMOR SEEN (0/1). B. SENTINEL LYMPH NODE #2, LEFT AXILLA, BIOPSY: - ONE LYMPH NODE, NO TUMOR SEEN (O/1). C. breast, Left, mastectomy: - INVASIVE DUCTAL CARCINOMA, POORLY DIFFERENTIATED (SBR GRADE 3), WITH ULCERATiON OF THE NIPPLE. - TUMOR MEASURES 2.5 CM IN GREATEST DIMENSION. - MARGINS, NO TUMOR SEEN.  ONE LYMPH NODE WITH NON-NECROTIZING GRANULOMAS, NO TUMOR SEEN (0/1) (SEE NOTE) NOTE: Special stains have been ordered on the lymph node and those results will be reported in an addendum. A CD31 stain has been ordered for evaluation of lymphvascular invasion and those results will be reported in an addendum. D. SENTINEL LYMPH NODE #3, LEFT AXILLA, BIOPSY:  - ONE LYMPH NODE, NO TUMOR SEEN (0/1). E. breast, Left, Upper Outer QuaDrant, EXciSiOn: - FIBROADIPOSE TISSUE, NO TUMOR SEEN.E F. SENTINEL LYMPH NODE #4, LEFT AXILLA, BIOPSY: - ONE LYMPH NODE, NO TUMOR SEEN (0/1). G. BREAST, LEFT, INFERIOR MEDIAL MARGIN, EXCISION: - FIBROADIPOSE TISSUE, NO TUMOR SEEN. SYNOPTIC REPORT - BREAST Specimen Type: Mastectomy Needle Localization: No Laterality: Left Invasive Tumor: Present Multifocality:  No WHO CLASSIFICATION  Invasive ductal carcinoma, NOS 8500/3 Tumor size: 2.5cm Tumor Site: Central Margins:  Negative Distance from closest margin:e Greater than 1cm deep Tubular Score: 3 Nuclear Grade: 3 Mitotic Score: 3 Modified Scarff Bloom Richardson Grade:. Necrosis: Absent Lobular neoplasia: None Lymph nodes: Sentinel lymph node only. Lymph node status: Negative 0/5 DCIS not present ER/PR/HER2 Results ER: Positive PR: Positive HER2: Positive by FISH Pathological staging (pTN): pT 2 N 0 Clinical history: year-old Jecent dx of left breast cancer in. , core biopsy -IDC ER/PR positive, Her2 ;illegible) . Now'for left mastectomy and sentinel iymph node biopsy-2 cm retroareolar mass.
+
+--- Page 3 ---
+PRE-OPERATIVE DIAGNOSIS: Left breast cancer. ADDENDUM:  NOTE: A CD31 stain was performed on C4 and is negative showing no evidence of lymphvascular invasion. Special stains (GMS, AFB, PAS) were performed on the lymph node (C18) and are negative showing no evidence of funaal or acid fast organisms. The non-necrotizing granulomas wouid be consistent with the patient's history Gross Dictation: Pathologist, Microscopic/Diagnostic Dictation: Pathologist, Final Review: Pathologist,. Final: Pathologist,. Addendum: Patholugist, Addendum Final: Pathologist,
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diff --git a/output/text/2a80a5f0-4457-41b8-afcf-53039ebb64de.txt b/output/text/2a80a5f0-4457-41b8-afcf-53039ebb64de.txt
new file mode 100644
index 0000000000000000000000000000000000000000..848b484b6cbac7a5f01552397c39eaf58281c570
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+page 1 / 1 Department of Cancer Pathology copy No. Date: Examination: Histopathological examination Internal invoice No. Value of diagnostic procedure Examination No.: ' Patient: XXX PESeL: XXX Age: Gender: F Material: Multiple organ resection - left breast With axillary tissues 1cs-0-3 Unit in charge: Cucnomo, mfi(trstny duct,Nos 8500f3  Physician in charge: Site. bresot, Nos c5o.9 p 4f1| Material collected on:' - Material received on:' Expected time of examination: up to 8 working days Clinical diagnosis: Cancer of the left breast.. Examination performed on: Macroscopic description: Left breast sized 22 x 15 x 4 cm removed along with axillary tissues sized 10 x 6 x 2 cm and a 17 x 6.5 cm skin flap. Weight 780 3. A post-operative scar visible round the nipple with a site of 6 x 4 x 2 cm. Microscopic description: Infiltratio carcinomatosa mamillae. Status post resectionem tumoris.. Glandular tissue containing foci of carcinoma ductale in situ (solid and cribrate type, with medium nuclear atypia, with  necrosis and calcifications, as well as lesions of the type mastopathia fibrosa. Axillary lymph nodes: Lymphonodulitis chronica (No VIII). Preliminary result: (including the examination No. ' Carcinoma invasivum mammae sinistrae.. (NHG2, pT2, pN0). Compliance validated by:. Examination performed on: Histopathological diagnosis: Carcinoma ductale invasivum mammae sinistrae. Invasive ductal carcinoma of the left breast.  NHG2, pT2, pN0. UUID:FC3854EB-6FBF-4DC4-B4D5-DB533687FA588 TCGA-D8-A1XF-01A-PR Redacted Compliance validated by
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diff --git a/output/text/2acdca9d-4c33-4c6e-a18f-c19c54523b87.txt b/output/text/2acdca9d-4c33-4c6e-a18f-c19c54523b87.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b0561fb31418d8455ff8205f3b93f4305cf52853
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+ifo Petolor Phone Pax Specimen: Received: Status: Req#:  Spec Type: SURGICAL P Subm Dr: PREOPERATIVR DTAGN: 1c0-0- 3 LEFT BREAST CANCER INVASIVE Corciioma, nfi1t^atw9 duct, nos 850o/3 Srt: brast Nos C50.9 OPERATTON PERFORMED 1107 DATE: DOCTOR(s) : PROCEDURE: MASTECTOMY MODIFTND RADIC PISSE REEOVED UUID:90F13DE2-7C8F-4FA2-B9BF-D68EEC37D514 TCGA-A2-A0Y3-01A-PR Redacted A. LEFT MODIFIED RADICAL MASTECTOMY B. LT DEEP MARGIN BENEATH TUMOR GROSS DEST: PTO! PART A RECEIVED LABELED   LEFT MODIFIED RADICAL MASTECTOMY STITCH AT 12 O'CLOCK, IS A LEFT MODIFIED RADICAL MASTECTOMY WITH A SKIN ELLIPSE MEASURING 20 X 8.5 CM WITH A GROSSLY UNREMARKABLE NIPPLE. THE SPECIMEN ITSELF MEASURES 26.5 X 14 X 3.5 CM. THE AXILLARY CONTENTS ARE DISSECTED OFF THE SPECIMEN AND THIS AREA IS MARKED WITH RED INK DENOTING THAT THIS IS NOT A TRUE MARGIN. THE AXILLARY TAIL IS EXAMINED FOR LYMPH NODES.  IN THE LOWER AXILLARY TAIL THERE IS A 3.7-CM IN GREATEST DIMENSION GROSSLY POSITIVE LYMPH NODE. ADDITIONAL NODES ARE ALSO IDENTIFIED.  TWO ADDITIONAL GROSSLY POSITIVE NODES ARE SUBMITTED, ONE SECTION EACH, IN A1 AND A2 WITH MIRROR IMAGES PER PROTOCOL. GROSSLY UNREMARKABLE LYMPH NODE WITH MIRROR IMAGE IN PROTOCOL. A4--ONE A3 IS A SECTION OF A GROSSLY POSITIVE LYMPH NODE WITH MIRROR IMAGE PROTOCOL, A5--LARGEST LYMPH NODE, A6--TWO NODES, EACH BISECTED, A7--TWO NODES, EACH . BISECTED, A8--NINE NODES. EIGHTEEN LYMPH NODES ARE IDENTIFIED IN ALL. THE SUPERFICIAL ASPECT OF THE BREAST IS THEN MARKED WITH BLUE INK, THE DEEP WITH BLACK INK. LATERAL TO THE NIPPLE THERE IS A PINK-TAN FIRM GRITTY MASS MEASURING 7 X 3 X 4.5 CM. THIS GROSSLY EXTENDS TO WITHIN 0.2 CM OF THE DEEP MARGIN.   CENTRALLY IN THE BREAST THE TISSUE IS TAN AND FIBROUS.  THE PERIMETER OF THE SPECIMEN IS FATTY WITH FINE FIBROUS BANDS. SECTIONS OF THE BREAST ARE SUBMITTED AS FOLLOWS: A9--NIPPLE AND SKIN (MIRROR IMAGE TO PROTOCOL). A1O--SECTION OF TUMOR TO INCLUDE DEEP MARGIN (MIRROR IMAGE TO PROTOCOL), A11 THROUGH A16--A FULL CROSS SECTION FROM SUPERIOR TO INFERIOR OF THE LESION TO INCLUDE THE DEEP MARGIN IN A11, 12, 14, AND 16 WITH A13 AND A15 REPRESENTING THE SUPERFICIAL SECTIONS TO A12 AND A14, RESPECTIVELY, A17--TUMOR AND DEEP MARGIN, A18--THE MOST LATERAL ASPECT OF THE LESION, A19--THE MEDIAL ASPECT OF THE LESION (4.5 CM FROM PREVIOUS SECTION), A20--LOWER OUTER QUADRANT, A21--UPPER OUTER QUADRANT, A22--UPPER INNER QUADRANT 5 CM FROM TUMOR, A23-LOWER INNER QUADRANT 5 CM PART B RECEIVED LABELED  WM DEEP MARGIN BENEATH TUMOR STITCH NEW MARGIN, IS AN IRREGULAR PORTION OF RED-TAN MUSCULAR TISSUE WITH CAUTERY ARTIFACT ON THE SIDE WITH THE SUTURE DENOTING THE NEW MARGIN. THIS MEASURES 2.7 X 2.5 X 0.4 CM IN GREATEST DIMENSIONS.  THE
+
+--- Page 2 ---
+Chief ot Fathology Phone rax 1 Patiente +yx .. (Continued), Specimen: Received: Status: Spec Type: SURGICAL P Req#- 8ubm Dr: (Continued) SIDE DESIGNATED AS THE NEW MARGIN IS MARKED WITH BLUE INK WITH A PERIMETER OF BLACK INK.  THE SPECIMEN IS SECTIONED AND ENTIRELY SUBMITTED LABELEN R1 THROUGH 3. PATH! PROCEDURES PROCADURES : 88307, 88309, A BLK/23, B BLK/3 PART A LEFT MODIFIED RADICAL MASTECTOMY: IN SITU AND POORLY DIFFERENTIATED INFILTRATING DUCT CARCINOMA, NUCLRAR GRADE 3 OF 3 WITH A HIGH MITOTIC INDEX. GROSSLY THE TUMOR SPANNED A DISTANCE OF 70 MM. LYMPHATIC SPACE INVASION IS PRESENT. A HIGH-GRADE IN SITU COMPONENT OF THE COMEDOCARCINOMA TYPE IS PRESENT. 7O TO 8Ot OF THE TUMOR IS INVASIVE.  INVASIVE CARCINOMA IS LOCATED IN THE LYMPHATIC SPACES AT THE DEEP MARGIN AND WITHIN THE STROMA OF THE BREAST I.1 MM FROM THE DEEP MARGIN.  TUMOR IS PRESENT IN A LYMPHATIC SPACE IN A SECTION FROM THE LOWER OUTER QUADRANT OF THE BREAST ANAY FROM THE GROSSLY IDENTIFIABLE PRIMARY LESION.  METASTATIC CARCINOMA IS PRESENT IN 5 OF 18 AXILLARY LYMPH NODES. PART B DEEP MARGIN BENEATH TUMOR, REEXCISION: TUMOR IDENTIFIED. SKELETAL MUSCLE WITH NO 1 Signed M.D. (prelim.) (signature on file)
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new file mode 100644
index 0000000000000000000000000000000000000000..0b01180277ebf8d1bca4cc1d1cfd538a46f1996b
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+Surgical Pathology Report. Name: Case #: DOb: Collected: Gender: Received: MRN: Reported: Location: Copy To: Physician: Pathologic Interpretation: 10s-0-3 A. Lymph node, sentinel lymph node: Carcinomn mifiItatm duchl, nos 850c/3 - No malignancy seen in one lymph node (0/1). - Keratin immunostain pending. Sh: brcat, Nos c50.9 3/1) hw B. Skin left breast:  - Skin, no pathologic change. c. Left breast lumpectomy: - Infitrating poory differentiated ductal carcinoma, high nuclear grade, 2.4 cm in greatest dimension. - Margins of resection are free of tumor. - Lymphovascular space invasion is present. - Previous biopsy site identified. - The tumor cells are positive for ER and PR, and negative for Her2 - See tumor summary. D. Inferior margln, true blue margin: - No malignancy seen. E. Right breast tlssue: - Fibrocystic changes with stromal fibrosis, adenosis, and microcalcifications. - Previous biopsy site identified. Tumor Summary: UUID:76358109-41A0-4D5C-8894-F6A63A925961 TCGA-EW-A1OY-01A-PR Specimen Type: Excision Redacted Lymph Node Sampling: Sentinel lymph node(s) only Specimen Size: Greatest dimension: 7.5 cm Additional dimenslons: 5.5 x 4.0 cm Laterallty: Left Tumor Site: Not specified Size of Invasive Component: Greatest dimension: 2.4 cm Additional dlmensions: 1.5 x 1.0 cm HIstologic Type: Invasive ductal carcinoma Histologic Grade: Tubule Formation: Minimal less than 10% (score =3) Nuclear Pleomorphism: Marked variation in size, nucleoli, chromatin clumping, etc (score =3) Mitotic Count: Greater than 20 mitoses per 10 HPF (score =3) Total Nottingham Score: Grade ill: 8-9 points Pathologic Staging (pTNM) Primary Tumor: pT2 Regional Lymph Nodes: pNO Number examined: 1d Number involved: 0 Distant Metastasis: pMX Margins: Uninvolved by invasive carcinoma Venous/Lymphatic Invasion: Present  Microcalciflcations: Present in both tumor and non-neoplastic tissue Commente : ER: Positive PR: Positive 1 Her2: Negative ()
+
+--- Page 2 ---
+SUrGICAL PathOL Report NOTE: Some immunohistochomicel antibodies are analyte specfic reagents (ASRs) veidated by our with formain or molecutar hixed, paramin embecded tissue. Dexection is by LSA8. The resuts are read by a pathologist as positive or negative. . MD As the attending pathologist, I attes! that I: (i) Examined the relevantd preparation(s) for the specimen(s); and (i) Rendered the diegnosis(es). Procedures/Addenda Date Ordered: Status: Signed Out Addendum Date Complete: Date Reported: Addendum Diagnosis Keratin immunostain is negative for carcinoma. , MD Intraoperative Consultation AFS. Sentinel lymph node #1: Touch prep only: Lymphoid cells. No malignant cell seen. CFS. Left breast lumpectomy: Portion from mass (1 x 0.5 x 0.3cm) taken for tissue bank.. Clinical History: female with history of breast cancer. Patient is ad Pre Qperative Diagnosis: Left breast cancer Specimen(s) Received: A: Lymph node, sentinel lymph node B: Skin left breast C: Left breast lumpectomy D: Inferior margin, true blue margin. E: Right breast tissue (fresh) Gross Description:. A. Received fresh and iabeled lymph node, sentinel lymph node" consists of a lymph node, 1.0 x 0.8 x 0.7 cm. Specimen is multisected and submitted in toto in one cassette for touch prep. *Pag6 2 of 3
+
+--- Page 3 ---
+B. Received in formalin and labeled *skin left breast" consists of a ellipse of skin, 5.0 cm in length by 1.7 x 0.4 cm.. Representative section submitted in one cassette..  Received fresh and labeied "left breast lumpectomy 1short superior 1 long lateral~consists of a lumpectomy which weighs  90.0 grams after formatin fixation and measure 7.5 cm from medial to lateral, 5.5 cm from anterior to posterior and 4.0 cm from superior to inferior. Specimen inked as follows. Superior and inferior margin inked black, medial and lateral margins inked orange, posterior margin inked red and anterior margin inked green. A piece of tumor was taken tumor bank, 1.0 x 1.0 cm. Cut sections of the specimen reveal a stony hard tumor which measure approximately 2.4 x 1.5 x 1.0 cm. The tumor is surrounded by fibrous tissue and has an ill-defined border of fibrosis. The areas of ill-defined, fibrosis measure 5.0 x 3.0 x 3.0 cm in greatest dimension. The small area of hemorrhagic which measure 0.8 x 0.4 x 0.3 cm is located 0.8 cm away from the deep posterior margin and the margin submitted as follows. 1 Lateral margin 2 Posterior and inferior margin. 3  Superior and anterior margin. 4 Additional sections of the anterior margin. 5 Sections of the medial margin grossly suspecious area of tumor involvement is located 0.8 cm away from the closest margin which is posterior and inferior. 6 &7 Additonal sections of the tumor in relation to the psoterior and inferior margin 8&9 Additonal sections of the fibrotic area at the inferior and posterior margin 10-12 Additonal sections of the biopsy cavity in relation to the inferior and posterior margin 13 Sections of the tumor in relation to the superior and anterior margin D.  Received in formalin and labeled "inferior margin, true blue margin" consists of a present of breast tissue, 7.0 cm in length by 4.0 x 1.2 cm in greatest thickness. One size of the specimen inked in methylene blue and re-inked in black. E. Received fresh and labeled *right breast tissue (fresh)" consists of a fragment of fibro-adipose tissue, 7.0 cm in depth by 5.0 x 3.0 cm. An overlying ellipse of skin measuring 3.0 x 1.0 cm in greatest dimension. The specimen weighs. approximately 55.0 grams. Specimen is unoriented. Specimen inked black. Cut sections reveal that the specimen consists. of 60.0 % cyst fibro-stroma and 40.0 % adipose tissue. The tumor or suspicious areas are grossly identifiable. Sections of the stroma and skin are submitted in three cassettes. ICD-9(s);) 174.8 610.1 793.81 ual/Syn Page 3 of 3
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index 0000000000000000000000000000000000000000..45561e4a91a66ddfd5d1585bacf3479f9b64c104
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+M (176.0cm 73.4kg BSA: 1.89m2 Accession Specimen Date/Time: ZD-0-3 DIAGNOSIS (A) RIGHT PARTIAL GLOSSECTOMY: arenSne, squomdo INVASIVE SQUAMOUS CARCINOMA - Moderate to poorly differentiated ceLL xos' O 8oz0/3 Tumor Features: Gross: Ulcerating Sit Jongue NoS Size: 1.7 cm in largest dimension C0q.9 Invasion: Present. depth 1.1 cm Tumor Border: Infiltrative with thin cords < 4 cells JtO 8/9113 Perineural Invasion: Absent Vascular Invasion: Absent. Mucosal and deep margins, negative for tumor. (B) RIGHT NECK DISSeCTION, LEVEL I: Submandibular gland, negative for tumor UUID:4BA4D262-78AF-4EF0-8689-2A09BE7585DC Seven lymph nodes, negative for tumor (0/7) TCGA-CV-A6K0-01A-PR Redacted (C) RIGHT NECK CONTENTS, LEVEL II: One submandibular gland, negative for tumor Five lymph nodes, negative for tumor (0/5) (D) RIGhT NECK CONTeNTS. LEVeL III: Eight lymph nodes, negative for tumor (0/8) GROSS DESCRIPTION (A) RIGHT PARTIAL GLOSSECTOMY, DOUBLE STITCH TONGUE TIP, SINGLE STITCH RIGHT VENTrAL MARGIN - A partial glossectomy specimen 4.5 x 2.5 x 2 cm. An ulcerating and partially exophytic mass (1.7 x 1.4x 1.1 cm) is at least 0.5 cm from the deep and mucosal margins. The specimen is serially sectioned from anterior to posterior. SECTION CODE: A1, frozen section full cross section with closes peripheral and deep margins; A2 -- A7, additional. sections of tumor from anterior to posterior. *FS/DX: SQUAMOUS CARCINOMA, MARGINS FREE. (8) RIGHT NECK DISSECTION, LEVEL I - A submandibular salivary gland (3.5 x 2.0 x 1.0 cm) and multiple lymph nodes are identified. SEcTiON CODE: B1, representative salivary gland: B2, one possible lymph node bisected; 83. one possible lymph node. bisected: 84, three possible lymph nodes; B5. two possible lymph nodes. (C) RIGHT NECK CONTENTS, LEVEL II - Multiple possible lymph nodes are identified. SECtION cODE: C1, possible salivary gland: C2-C4. one possible lymph node bisected per cassette; C5. two possible. lymph nodes (D) RIGHT NECK CONTENTS. LEVEL III - Multiple lymph nodes are identified SECTION CODE: D1-D4. one possible lymph node bisected per cassette: D5, three possible lymph nodes. CLINICAL HISTORY SNOMED CODES T-53000. M-43000, M-80703, *Some tests reponed here ray nave been deveioped and performance cnaracienstcs determined by. These tests nave not been specifically cleared or approved by he u S. Food and Drug Adminstration.*. Entire report and diagnosis completed by
+
+--- Page 2 ---
+Page: 2 (176.0aa 73.dkg 83A: 1.89m) Aeeasion: Specimen Dare/Tine: -End Of RepOrt-
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diff --git a/output/text/2b1b3786-a961-4d73-9bc7-439305fc5c23.txt b/output/text/2b1b3786-a961-4d73-9bc7-439305fc5c23.txt
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index 0000000000000000000000000000000000000000..02863c49d9d8bde0a5d410ef64111ea7f0af7c09
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+ICD O 3 Casnoma, poapellauy reral cefl 8xo0|3 UUID:AC0E8FA4-CAE2-46B2-97E0-CEDD20001A04 TCGA-5P-A9K9-01A-PR Site: DWidreyNgS Redacted "C64.4 QO 6|t3|14 Papillary Renal Cell Carcinoma, Type I (solid growth component), poorly differentiated ICD-0-Code: 8260/3 Leerality MN 5/4/14
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diff --git a/output/text/2b3bf325-c2be-44c3-8e17-77597731fe81.txt b/output/text/2b3bf325-c2be-44c3-8e17-77597731fe81.txt
new file mode 100644
index 0000000000000000000000000000000000000000..676db3c5c8a056cc44ed2c1cc1a612c238e88899
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+
+--- Page 1 ---
+SURGICAL PATHOLOGY Surgical Pathology Report Diagnosis: Colon, ascending, right hemicolectomy. Tumor Histologic Type: adenocarcinoma, colon primary (see comment) Histologic Grade: low grade (grade 2 of 4, moderately differentiated) Tumor Size: 8.2 cm Tumor Location: cecum Depth of Invasion: through muscularis propria and into pericolonic adipose tissue, no definitive penetration or perforation of visceral peritoneum identified Lymphovascular Invasion: not identified Perineural Invasion: not identified. Margins: negative Proximal margin: 10.1 cm Distal margin: 11.6 cm Mesenteric vascular margin: 6.1 cm. Regional Lymph Nodes: Total number with metastases: 0. Total number examined: 16 Additional Pathologic Findings: Focal mucinous differentiation (less than 10% of tumor), no significant intra- or peritumoral lymphoid response, fibrous obliteration of appendiceal Iumen. AJCC PATHOLOGIC TNM STAGE: pT3 pN0 Note: This pathologic stage assessment is based on information available at the time of this report, and is subject to change pending. clinical review and additional information.. Immunohistochemistry for mismatch repair protein expression:. MLH1: loss of nuclear expression (abnormal phenotype), positive internal control present. MSH2: normal phenotype MSH6: normal phenotype Comment: Materials are submitted to the Molecular Pathology lab for microsatellite instability (Msl) testing. The results will be reported. separately. Clinical History: colon cancer. Gross Description: Received is one appropriately labeled container, additionally labeled "ascending colon.". Specimen fixation: formalin Parts of bowel received: terminal ileum (10.3 cm long x 4.1 cm in circumference), large bowel (18.7 cm long x 7.2 cm in
+
+--- Page 2 ---
+circumference), appendix (4.7 cm long x 1.0 cm in diameter) and pericolonic adipose tissue (21.2 x 6.5 x 6.5 cm) Specimen length: please see "Parts of bowel received". Orientation: proximal mucosal margin=blue, radial margin=red, distal mucosal margin=black. Tumor location: proximal ascending colon Gross appearance of tumor: The mass is firm, pink/tan and fungating with raised borders and central ulceration. The mass involves the ileocecal valve.. Tumor dimensions: 8.2 x 5.1 x 2.5 cm (protruding into the lumen) Circumferential growth: approximately 90% of lumen involved by mass Gross depth of invasion: The mass extends through the muscularis propria and into the underlying adipose tissue.. Gross evidence of perforation through visceral peritoneum: no Luminal obstruction: The lumen is obstructed and the diameter of the lumen at the tumor site is 1.4 cm Bowel circumference at tumor site: 8.7 cm. Gross distance of tumor from margins: The mass is 10.1 cm to the proximal margin, 11.6 cm to the distal margin, 3.4 cm to the Iateral edge of the specimen margin, and 6.1 cm to the mesenteric pedicle margin. Other comments: The terminal ileal mucosa is tan/gray and slightly granular. The uninvolved colonic mucosa is unremarkable. The appendix is unremarkable.. Lymph nodes: Sixteen lymph node candidates are identified ranging from O.5 cm in greatest dimension up to 1.0 cm in greatest  dimension. Other remarkable findings: none Tissue submitted for special investigation: Yes; normal and tumor given tq Digital photograph taken: no. Block summary: (Inking: Proximal mucosal margin=blue, distal mucosal margin=black, radial margin=red). A1 - proximal mucosal margin, en face A2 - distal mucosal margin, en face A3 - radial margin, en face A4 - pedicle margin, en face. A5,A6 - full thickness section of mass, bisected. A7 - full thickness section of mass A8 - additional section of mass into the underlying adipose tissue A9 - mass with ileocecal valve A10 - appendix A11 - four lymph nodes A12 - two lymph nodes, each bisected; one inked black. A13 - two lymph nodes, each bisected; one inked black. A14 - three lymph nodes, each bisected; one inked blue, one inked black A15 - two lymph nodes A16 - one lymph node, serially sectioned A17 - one lymph node, serially sectioned A18 - one lymph node, bisected
+
+--- Page 3 ---
+Light Microscopy: Light microscopic examination is performed by. For cases in which immunostains are performed, the following applies: Appropriate internal and/or external positive and negative controls have been evaluated. Some of the immunohistochemical reagents used in this case may be classified as analyte specific reagents (AsR). These were developed and have performance characteristics determined by the. These reagents have not been cleared or approved by the US Food and Drug Administration. (FDA). The FDA has determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They. should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of  as qualified to perform high complexity clinical laboratory testing. Signature Attending Pathologist: I have personally conducted the evaluation of the above specimens and have rendered the above. diagnosis(es).
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diff --git a/output/text/2b5fc2ba-8d5f-4e47-a733-118c13e07907.txt b/output/text/2b5fc2ba-8d5f-4e47-a733-118c13e07907.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e19a6282e08c517c790d98623687aa6be03ccc93
--- /dev/null
+++ b/output/text/2b5fc2ba-8d5f-4e47-a733-118c13e07907.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Accession #: Date of Procedure: Date of Receipt: Date of Report: Account #: Billing Type: Additional Copy to: Ref. Source: TCGA- BP-4971 Clinical Diagnosis & History!. with large right ranal mass - g250 (+). Specimens Submitted: 1: SP: Kidnay, right, tatal nephractony. 2: SP: Lymph node, precaval, paracaval and retrocaval, excision. 3:SP:Adrenal gland, right, adranalactomy. DIAGNOSIS: SP: Kidnay, right, total nephractamy. Tumor Type: Ranal cell carcinoma - Convantional (cloar call) typa. Fuhrman Nuclear Grade:  Nuclaar grada l/IV Tumor Size: Greatest diameter is 8.1 cm. Local Invasion (for renal cortical types): Invalves renal sinus fat Renal Vein Invasion: Vassals wih muscular wall ara involved by tumor. Surgical Margins:  Free of tumar Non-Neoplastlc Kidnay: Focal granulomatous raaction and glomerulosclerosis. Adranal Gland: Not idantified Lymph Nodes: Not identified Staging for ranal call carcinoma/oncocytama: pT3a Tumor Invadas the adranal gland or parinephric tissues but not bayond Gerata's fascia 2. SP: Lymph nade, precaval, paracaval and retrocaval, axcislar Lymph Nodes: Not invalved  Number of nadas axaminad:5 Page 1 of 3
+
+--- Page 2 ---
+Benign segment of vessel Is also identified. 3.SP: Adrenal gland, right, adrenalectomy. Benign adrenal gland 1 ATTEST THAT THE ABOVE DIAGNOSIS jS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Special Studies: Result Speciel Stain Comment AE1:AE3 NEG CONT IMM RECUT AE1:AE3 NEG CONT IMM RECUT AE1:AE3 Gross Description: 1).  The specimen is received fresh, previously incised and placed in formelin, labeled "Right kldney" and consists of a totel nephrectomy specimen with an attached ureter, renal vessels and perinephric fat, weighing 642 g post fixatlon. The external surface has been inked black. The kidney measures 12.5 x 8.3 x 4.6 cm. The attached ureter measures 3.3 cm in length and 0.4 cm In diameter in greatest dimension. ' The ureteral margin is identified and appears grossly uninvolved by tumor. On opening, the ureter is lined by o pink-ton soft faintly corrugated tissue. The attached renal vessels are identified, with a slight srea of firmness Identified at the distal aspect of the smeller vessel, and the margins appear grossly uninvolved by tumor. The capsuler surface is smooth end pink-ian. The kldney is bivelved to reveal a pseudo encapsulated yellow-red tumor mass measuring 8.1 x 7.5 x 4.3 cm, occupying the superior and mid poles of the kidney, which appears to be partially surrounded by a rim of dense white fibrous tissue. The mass appears to focally protrude Into the sinus fat with possible focal invesion, but does not grossly invoive the renal peivis. At the cenler of the mass, an ill-defined frm white-ten focally hemorrhagic scarred erea is identlfied measuring 2.8 x 2.3 cm in greatest dimenslon. Focal areas of necrosis are also identified. The mass abuts the renal celyces and serial sectioning reveals possible invasion by soft friable red-tan tumor tissue. The attached perinephric fat has been inked black and on cut section reveals a focal area of possible extracapsular extension into the fat. The Inked margins do not appear to be grossly involved by tumor. Sectioning through the remainder of the kidney reveals a pink brown parenchyma, which appears grossly unremarkable. The corticomedullary junction is well delineated, with the cortex measuring O.6 cm in width. Sectioning through the perinephric fet reveals no grossly identifiable lymph nodes. Representative sections of the specimen are submitted to TPS for permanent section and photographs have been taken.. Summary of sections: VM - vessel margin shave UM - ureter margin sheve. TWP -- tumor with pelvis. TWS -- tumor with sinus TWN ~ tumor with normal. R$t - representative sections tumor RS - representative sections normel kidney TWC  tumor with possible extension into calyces. TWF - tumor with fat 2). The specimen is received In formalln, Iabeled *Precaval, paracavel lymph nodes and retrocaval lymph nodes" and consists of. multiple hemorrhagic lymph nodes renging in size from 0.8 to 1.7 cm. A smooth pink-tan tubuler piece of vasculer tissue is also Page 2 of 3
+
+--- Page 3 ---
+identlfied measuring 3.0 x 0.5 cm, with each end stapled. Cut section reveals a patent lumen. Representative sections of the. vein are submitted in the lymph nodes, completely sectloned at 3 mm intervals and submitted.. Summary of sections: V -- representative sections blood vessel BN1 -- bisected lymph node number one BN2 - bisected lymph node number two BN3 -- bisected lymph node number three TLN -- trisected lymph node RSN -- lymph node at 3 mm intervals 3).  The specimen is received in formalin, labeled "Right adrenal gland' and consists of a total adrenalectomy specimen, with. attached adipose tissue measuring 51 x 2.9 x 1 .0 cm and weighing 10.5 g post fixstion. The external surface is inked black, and serial sections reveal a rim of bright yellow soft tissue, with central areas of tan and dark red soft tissue noted. Representative sections are submitled. Summary of sections: RS -- representative sections Summary of Sections: Part 1: SP: Kidney, right, total nephrectomy Block Sect. Site. PCs 1 rs 1 5 rst 5 N twc N 1 twf +* 1 twn 1 1 twp 1 2 tws 2 1 um 1 vm 1 Part 2:  SP: Lymph node, precaval, paracaval and retrocoval, excision. Block Sect, Site. PCs bn1 1 7 1 bn2 1 1 bn3 1 1 rsn 1 1 tin 1 1 V 1 Part 3: sp: Adrenal gland, right, adrenalectomy Block Sect. Site. PCs 4 rs 4 Page 3 of 3 END OF REPORT
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diff --git a/output/text/2b6dd4df-e802-4d69-9306-055efc574163.txt b/output/text/2b6dd4df-e802-4d69-9306-055efc574163.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8228aed89013f7c72419ef522d28ef1fd6eabb54
--- /dev/null
+++ b/output/text/2b6dd4df-e802-4d69-9306-055efc574163.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:AD597E1C-BC15-46A3-987C-324250540805 TCGA-BT-A3PK-01A-PR Redacted Collection Date: FINAL DIAGNOSIS: PART 1: Retroperitoneal soft tissue, mass, resection  LOW GRADE MUCINOUS NEOPLASM INVOLVING FIBROADIPOSE TiSSUE (see comment). Part 2: Ureter, right distal, biopsy - BENIGN UROTHELIUM-COVERED TISSUE; NO TUMOR PRESENT. PART 3: Ureter, left distal, biopsy -- BENIgN UROTHeLIUm-COVERED TISSUe; NO TUmOR PRESENT. PArt 4:  URInARy BLADDER, RADICAl CySTECTOmY -- A. INVASIVE UROTHELiAL CARCINOMA, HIGH-GRADE. B. TumOr measures 4.7 Cm In greaTest DimensiOn. C. TUmOR inVADeS DETRUSOR MUSCLe (mUSCULARiS PROPRIA). D. PERINEURAL INVASION AND ANGIOLYMPHATIC INVASION IS NOT IDENTIFIED. E. THE URETHRAL MARGIN SHOWS UROTHELIAL DYSPLASIA. F. ALl Other ResectiOn margins Are free Of tumOr (see also parts 7 and 8). G. BACKGROUND UROTHELIUM SHOWS ACUTE AND CHRONIC INFLAMMATION AND REACTIVE CHANGES. H. PathologIc StAge: pt2b N0 mX. PART 5: Lymph nodes, Right pelvic, Selective Dissection- Three Lymph nOdes; nO tumor PREsent (0/3). PART 6: SMALL BOWEL, RESECTION A.  SegmenTs Of SmalL Bowel wITh Acute and ChrOnIC SeRositiS, CongestiOn, AdheSIOns AnD I OCA.L ISCHeMIC-TyPE CHAnGES.  RESECTION MARGINS ARE VIABLE-APPEARING. ICD-o-3 j0Fcinmq,u#r<1ia 1 PArt 7: Ureter, right, margin, biopsy --. 81a013 BENIGN UROTHELIUM-COVERED TISSUE; NO TUMOR PRESENT. 'CQcr Si+: blccer,poskn*oy wa11' C u7,4 PART 8: Pa+h: bhd&rN0s Ce7.q Ureter, left, margin, siopsy - Benign urothelium-cOvered tissue with reactive Changes; nO tumor present. CASE SYNOPSIS: SyNOPTiC DATA - PRImARy URiNARy bLADDeR TUmORS SPECIMEN TYPE: Radical cystectomy TUMOR SITE: Posterior wall, Dome TUMOR SIZE: Greatest dimension: 4.7 cm HISTOLOGIC TYPE: Urothelial (transitional cell) carcinoma ASSOCiATED EPITHELIAL LESIONS: None identified HISTOLOGIC GRADE: Urothelial carcinoma - High-grade TUMOR CONFIGURATION: Papillary, Solid/nodule PATHOLOGIC STAGING (pTNM): pT2b pNO Number of nodes examined: 3. pMX MARGINS: Margins uninvolved by invasive carcinoma Margin: URETHRAL MARGIN WITH UROTHELIAL DYSPLASIA VENOUS/LYMPHATIC (LARGE/SMALL) VESSEL INVASION (V/L): Absent DireCT eXTenSIOn OF InVaSIVE TumOR:  None identified ADDITIONAL PATHOLOGIC FINDINGS:E  Inflammation/regenerative changes LIFIDDISOU
\ No newline at end of file
diff --git a/output/text/2b8326f6-7742-472b-9973-f2e7171eebf2.txt b/output/text/2b8326f6-7742-472b-9973-f2e7171eebf2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..321d5ef82221e86ac678602e9a1be654b0d3c370
--- /dev/null
+++ b/output/text/2b8326f6-7742-472b-9973-f2e7171eebf2.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1D03 Date of surgery : Lslantna, lysithelisid 37>i13 Chcwl 0i93 Left eye enucleation. Cllualtwet 069.4 MO 3/0/14 Macroscopy The eye ball mesures 25 by 25 by 23 mm and presents a posterior segment of optic nerves measuring 5 mm. At the section, the tumor measures 18 mm main line. Samples have been frozen for genetic studies then the piece has been fixed and. included entirely Microscopy The tumor observed macroscopically corresponds to an uveal melanoma, mainly. composed of epithelioid cells. The cell cytoplasm is often pigmented with melanin. The cyto/nuclear atypia are severe. Presence of large areas of necrosis and. hemorragy, in particular at the centre of the tumor. The lesion is located at a large distance of the optic foramen and the optic nerve on its entire course and cut end is free of tumor. The tumor infiltrates all of the thickness of the sclera but there is no extra-scleral tumor extension. Presence of one intra- scleral endovascular tumor embolism. The ciliary body, the iris and the anterior chamber are free. UUID:036B1D86-3517-47E4-B285-BACE886AC434 Conclusion Redacted Uveal melanoma of the left eye. Epithelioid cells predominant. Size of the tumor: 18 mm.. Tumor invasion of the sclera without extra-scleral extension. Intra-scleral endovascular tumor embolism. Optic nerve, ciliary body and anterior chamber free of tumor. lw is/3943
\ No newline at end of file
diff --git a/output/text/2bb51542-4d58-4f1c-85e7-8eb56a8c0bde.txt b/output/text/2bb51542-4d58-4f1c-85e7-8eb56a8c0bde.txt
new file mode 100644
index 0000000000000000000000000000000000000000..dc19acf683fba5c70c6ddd0ee6783c8439e70a2b
--- /dev/null
+++ b/output/text/2bb51542-4d58-4f1c-85e7-8eb56a8c0bde.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+TCGA-AS-3777 SURGICAL PROCEDURES: NEPHRECTOMY ACTCLINICALHISTORY . OTHER SPECIAL CONSULTATION: TA GROSSDESCRIPTION SA:. The specimen is submitted fresh as "left kidney and ureter" and consists of a kidney removed with attached perirenal fat weighing 361 grams with an overall dimension of 19 x 11 x 5 cm. The kidney measures 10 x 6 x 3.5 cm. The segment of attached ureter measures 8 cm in length and 0.6 cm in diameter. There are several segments of vessel at the hilum ranging in length from 0.4 to 1.5 cm in length and measuring up to 2 cm in diameter. The ureteral mucosa is pale tan with the usual striations. The pelvic mucosa is similar in appearance.  The renal parenchyma is red brown with. normal architecture. There is a 2 x 2.2 x 1.5 cm circumscribed yellow tan tumor adjacent to the renal pelvis which appears to abut upon the renal sinus and approaches to within 0.5 cm of the cortical surface. The calyces are not dilated. The cortex measures up to 0.8 cm in thickness. The capsule strips easily revealing an underlying red brown granular cortical surface. Examination of the attached perirenal fat is unremarkable. The adrenal gland is absent. Representative sections are. submitted, multiple (9) labeled as follows:** Cassette 1: Vessel and ureter margin. Cassettes 2-8: Tumor Cassette 9: Representative uninvolved renal parenchyma. Please note: A portion of tissue is collected for research study. ONAALEINALDIAGNOSISXMS LEFT KIDNEY AND PROXIMAL URETER (NEPHRECTOMY) : RENAL CELL CARCINOMA, CHROMOPHOBE TYPE (2.2 CM) . TUMOR IS LIMITED TO THE KIDNEY.
+
+--- Page 2 ---
+*TFINAL DIAGNOSIS (Continued) URETERAL AND VASCULAR MARGINS ARE NEGATIVE FOR TUMOR. BACKGROUND KIDNEY WITHOUT SIGNIFICANT CHANGES. COMMENT : THE TUMOR MORPHOLOGY IS CHARACTERISTIC OF THE CHROMOPHOBE TYPE OF RENAL CELL CARCINOMA, AND THE IMMUNOPROFILE FOUND ON THE PRIOR WAS ALSO SUPPORTIVE OE THIS DIAGNOSIS. . REPORT +++ . SYNOPTIC REPORT: KIDNEY (CAP/AJCC/ACS - REQUIRED ELEMENTS) SPECIMEN TYPE: NEPHRECTOMY LATERALITY : LEFT TUMOR SITE: CENTRAL/ADJACENT TO PELVIS TUMOR FOCALITY: UNIFOCAL TUMOR SIZE: 2.2 CM MACROSCOPIC EXTENT OF TUMOR: LIMITED TO KIDNEY HISTOLOGIC TYPE: CHROMOPHOBE RENAL CELL CARCINOMA HISTOLOGIC GRADE: N/A (FUHRMAN SYSTEM DOES NOT APPLY TO CHROMOPHOBE TYPE OF RENAL CELL CARCINOMA) VENOUS INVOLVEMENT : NOT SEEN ADRENAL INVOLVEMENT : N/A - ADRENAL NOT PRESENT MARGINS : CAPSULAR/PARENCHYMAL : NEGATIVE PERINEPHRIC FAT: NEGATIVE RENAL VEIN: NEGATIVE URETER: NEGATIVE LYMPH NODES: # INVOLVED/ # EXAMINED: 0/0 OTHER PERTINENT FINDINGS:  NONE pTNM STAGE: pT1a NX MX (STAGE I)
\ No newline at end of file
diff --git a/output/text/2bcf0df4-9650-4cf7-9a6c-c3326338f17b.txt b/output/text/2bcf0df4-9650-4cf7-9a6c-c3326338f17b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..706f2c1c01902c756c27dcd1d7bfad6adf199696
--- /dev/null
+++ b/output/text/2bcf0df4-9650-4cf7-9a6c-c3326338f17b.txt
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+
+--- Page 1 ---
+page 1 / 1 Department of Cancer Pathology copy No.. Z Date: Examination: Histopathological examination. Internal invoice No. Value of diagnostic procedure Examination No.: Patient: XXX PESEL: XXX Age: Gender: Material:  Partial organ resection - left half of the colon along with cancer infiltrated first loop of the small intestine Unit in charge:.  Physician in charge: Material collected on: Material received on: Expected time of examination: Clinical diagnosis: left half of the colon along with cancer infiltrated first loop of the small intestine Examination performed on: Macroscopic description: A 25 cm length of the large intestine with periintestinal fat tissue sized 28 x 6.8 x 2.5 cm, and part of the omentum sized 25 x 10 x. 0.5cm. Additionally an 8 cm segment of the small intestine consolidated with the wall of the large intestine at the site of neoplastic. proliferation. Ulcerous tumour sized 7 x 5 cm found in the mucosa. The lesion surrounds 100% of the intestine circumference. narrowing its lumen, is located 6 cm from the proximal incision line, and 12 cm from the distal incision line. The lesion infiltrates. macroscopically through the whole thickness of the large intestine wall, periintestinal fat tissue and the small intestine wall at the site of the consolidation. Neighbouring lymph nodes are macroscopically metastatic. Microscopic description: Adenocarcinoma tubulopapillare (G2). Infiltratio carcinomatosa profunda tunicae muscularis priopriae. et serosae coli et parietis ilei et telae adiposae mesenteril pericolicae. Intestine ends clear of neoplastic lesions.. Metastases carcinomatosae in lymphonodis (NO Iv/xiv). Infdtratio carcinomatosa capsulae lymphonodorum et telae adiposae perinodalis. Emboliae carcinomatosae. Histopathological diagnosis: Adenocarcinoma tubulopapillare coli. Tubulopapillar adenocarcinoma of the colon. Metastases carcinomatosae in lymphonodis. Cancer metastases in the lymph nodes. (No IV/xiv). (G2, Dukes C, Astler - Coller C2, pT4b, pN2). Compliance validated by: CONTACT YOUR DOCTOR WITH THIS REPORT!
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diff --git a/output/text/2bdcc7ad-f68b-40d8-ab40-74a61470eb3f.txt b/output/text/2bdcc7ad-f68b-40d8-ab40-74a61470eb3f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..cd4ce88872ba30fc6bc710dbdd42811a2482c9f5
--- /dev/null
+++ b/output/text/2bdcc7ad-f68b-40d8-ab40-74a61470eb3f.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+SURGICAL PATHOLOGY REVISED REPORT Case Number : UUID:98F0E34A-F78C-4BFD-AC4C-926FA1D60342 TCGA-AQ-A54N-01A-PR Redacted Diagnosis: A: Breast, left, partial mastectomy Tumor type: Invasive ductal carcinoma Nottingham combined histologic grade: 3 Tubule formation score: 3. Nuclear pleomorphism score: 3 Mitotic count score: 3. Tcdd-3 Focality of tumor: Unifocal. Cercinoma, Int1tratry DuctNo 8S00/3 Tumor size (greatest dimension): 4.9 cm Sre LBreast, NoS Lymphovascular invasion: Not identified Cs0.9 In Situ Component: Not identified Nipple involvement: Not applicable Skin involvement: Not identified Margin status: Invasive component: Negative; 0.3 cm to anterior margin (see comment), all other margins widely free of tumor In Situ component: Not applicable Axillary lymph nodes:. Total number with metastasis: 0 Total number examined: 1 Microcalcifications: Not identified Other findings: Duct ectasia. AJCC PATHOLOGIC TNM STAGE: pT2 pNO Note: This pathologic stage assessment is based on information available at the time of this report, and is subject to change pending clinical review and additional information.
+
+--- Page 2 ---
+B: Lymph node, sentinel left breast, removal. - No carcinoma identified in one lymph node (0/1) - Cytokeratin immunostain (AEl/AE3) negative. C: Breast, left lateral margin, stitch new margin, removal - No atypia or carcinoma identified D: Breast, left medial margin, stitch new margin, removal. - No atypia or carcinoma identified. Comment: The anterior margin represented in block A3 has ink within a somewhat fragmented tissue section that is 0.3 cm from tumor. The true margin may be closer to the gross measurement of 0.8 cm. Clinical correlation is advised. Clinical History: with left breast cancer. Gross Description: Received are four formalin-filled containers Container A is additionally labeled "left breast cancer, short stitch/superior, long stitch/lateral." Specimen fixation: formalin. Time in fixative: 8.5 hours. Type of mastectomy: left partial mastectomy. Weight of specimen: 229 grams. Size of specimen: 13.5 cm superior to inferior, 11 cm medial to lateral, 6 cm anterior to posterior Orientation of specimen: Medial-green, lateral-red, anterior-blue, posterior-black Skin ellipse dimensions: 12.1 x 5.2 cm ellipse of dark
+
+--- Page 3 ---
+brown/gray skin with no lesions identified. Nipple/areola: not present Axillary tail: not present Biopsy site: not present Discrete Mass(es): present Number of discrete masses: one Size of mass (es)/biopsy site: 4.9 x 3.6 x 3.8 cm Location of mass(es): central portion of resected specimen. Distance of mass/biopsy site from surgical margin: The mass is located 1.3 cm from the black inked deep margin, 2.9 cm from the medial margin, 2.7 cm from the lateral margin, 1 cm subjacent to. the skin and within 0.8 cm of the blue inked anterior. margin adjacent to the skin. Gross involvement of skin or fascia/muscle by tumor: absent Description of remaining breast: composed primarily of yellow. lobulated fat. which is blue dye stained along the superior edge.. There are delicate bands of white/pink fibroconnective tissue. coursing throughout the remainder of the specimen.. Other remarkable features: none. Tissue submitted for special investigations: Tumor is given to Tissue Procurement. Block Summary: (Inking: anterior-blue, posterior-black, medial-green,. lateral=red) Al - superior tip. A2 - inferior tip.
+
+--- Page 4 ---
+A3 - tumor and closest approach to blue inked anterior margin A4 - tumor and closest approach to black inked posterior margin A5 - closest approach to green inked medial margin A6 - closest approach to red inked lateral margin A7 - closest approach to skin A8,A9 - central tumor A10-A13 representative sections from breast tissue Container B is additionally labeled "sentinel node, left breast." It holds a 3.4 x 2.5 x 1.2 cm fragment of fat containing a 2.4 x 1.6 x 1.0 cm gray/tan lymph node candidate. The fat is removed and the lymph node candidate is sectioned to reveal a homogeneous gray/tan cut surface. The specimen is entirely submitted in blocks Bl-B3. A small amount of fat remains in formalin. Container c is additionally labeled "left lateral margin, stitch new margin." It holds a 13.2 x 6.5 cm discoid fragment of yellow/red fibrofatty tissue ranging in thickness from 0.6 to 1.7 cm. One surface has a stitch designating "new margin." This surface is marked with blue ink and the opposite surface is marked with red ink for identification purposes. Sectioning reveals yellow lobulated fat with no lesions grossly identified. Representative sections are submitted in blocks C1-c5. The majority of the specimen is retained in formalin. Container D is additionally labeled "left medial margin, stitch new margin." It holds a 10.7 x 5.6 cm discoid fragment of yellow/tan fibrofatty tissue with a uniform thickness of 1.8 cm. There is a stitch present on one surface designating the "new margin." This surface is marked with blue ink and the opposite surface is marked with red ink for identification purposes. The specimen is serially sectioned to reveal yellow lobulated fat with no discrete mass or nodule appreciated. Representative sections are submitted in blocks D1-D5.
\ No newline at end of file
diff --git a/output/text/2be3dd6f-0131-4ce5-9eda-43645f32debf.txt b/output/text/2be3dd6f-0131-4ce5-9eda-43645f32debf.txt
new file mode 100644
index 0000000000000000000000000000000000000000..54ec2dc9c306fa73a448d02044ff56775d0d8138
--- /dev/null
+++ b/output/text/2be3dd6f-0131-4ce5-9eda-43645f32debf.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+JUID:E B39F-DE08-45 5D7C3B6CE090 TCGA-RY-A847-01A-PR Redacted SURGICAL PATHOLOGy REPORt Patient Name: Accession #: Med. Rec.#: Visit #: Service Date: DOB: (Age: Sex: Male Received: Soc. Sec. #: Location: Client: Physician(s): Final Pathologic Diagnosis A. Brain, right frontal mass, biopsy: Oligodendroglioma, WHO grade II; see comment. B. Brain, right frontal mass, resection: Oligodendroglioma, WhO grade II; see comment. C. Brain, CUsA contents, resection: Oligodendroglioma, WhO grade II; see comment. Comment: Sections show infiltrating glioma cells with round, regular and monotonous nuclei, with sharply defined nuclear membranes and ample cytoplasm. There is no evidence of increased mitotic activity,. microvascular proliferation or necrosis. These findings are diagnostic of oligodendroglioma, WhO grade HI. Immunohistochemistry for IDH1 will be performed and the results will be reported in an addendum. In addition, fluorescence in-situ hybridization for 1p19q will be performed at the Iaboratory and the results will be reported separately. Intraoperative Diagnosis FS1 (A) Brain, tumor, biopsy: Low-grade glioma, most consistent with oligodendroglioma, WhO grade II. Tissue section and cytologic preparation. Gross Description The specimen is received fresh in three parts, each labeled with the patient's name and medical record number. Part A, additionally labeled "1 - tumor - Fs," consists of a single, irregular, unoriented, red-yellow. gelatinous brain tissue fragment (1.3 x 0.6 x 0.3 cm). Representative sections are submitted for frozen section diagnosis 1 and cytologic preparation. The frozen section remnant is submitted in cassette A1 and the remaining tissue is entirely submitted in cassette A2. LCD-Oe7 OsegodendogFiome,gaade II 945013 )QsI 10/30J3
+
+--- Page 2 ---
+Part B, additionally labeled "tumor - perm," consists of two pieces of tissue. The smaller (1.4 x 1.1 x 0.6 cm) is soft, irregularly-shaped, and white. The larger piece (2.6 x 2.1 x 1.1 cm) is irregularly-shaped and has a dark pink-red cortical surface with prominent gyri. The cut surfaces are. firm and comprised predominantly of white matter, with a narrow rim of dark pink-tan gray cortex (0.2 cm). The entire specimen is submitted in cassettes as foilows:. B1: Smaller piece. B2-B3: Larger piece. Part C, additionally labeled "CusA contents perm," consists of numerous, small, irregularly-shaped fragments of soft, white-tan to pink-red tissue (7 x 6 x 2 cm). Representative sections are submitted in cassettes C1-C12. Clinical History Relevant History:Glioma The patient is a -year-old man with a right frontal brain mass, most consistent with a low-grade glioma. Diagnosis based on gross and microscopic examinations. Final diagnosis made by attending pathologist following review of all pathology slides. The attending pathologist has reviewed all dictations and preliminary interpretations performed by any resident involved In the case and performed all necessary edits before signing the final report. Pathologist Pathology Resident Signed: Addendum Date Ordered: Status: Signed Out. Date Complete: By: Date Reported: Addendum Diagnosis This addendum is issued to report immunohistochemical findings and does not change the diagnosis for the case.. Addendum Comment Immunohistochemical studies performed and evaluated at our laboratory show that the neoplastic cells are positive with the antibodies against IDH-1 (R132H mutant) protein. The immunohistochemical stain reported above was developed and its performance characteristics determined by the. The stain has not been cleared or approved by the U. S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA) as quallfied to perform high-complexity clinical testing Pathologist Resident Electronically signed out on riterla l /5/8/e3 TumorSite Disreparcy r Maligr.ancy Histry /Synchronous Pimary Nte ase is {circle UALIFE .DISQLAUFIED te Revieweu: of8/Z613
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diff --git a/output/text/2c0035d5-2254-4d30-83c3-21d8b87319d7.txt b/output/text/2c0035d5-2254-4d30-83c3-21d8b87319d7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c0bc12a58c13ab927dffab8ac3e7edfc8d0277d8
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+--- Page 1 ---
+. T P.68 Anonymous No.: Age. Gender: F Race: White. CLiniCAl histoRy Not provided. LMP: Hysterectomy. PRE-OP DiAGNOSIS: RIght breast cancer. POSt-OP DiagnOsiS: Same. PROCEDURE: Right needle localized scgmental mastectomy and right sentinel node biopsy.. FINAL DIAGNOSIS PART 1:_ RIGHT BREAST. 4 O' CLOCK NEEDLE LOCALIZeD SEGMENTAL MASTECTOMY A. TWO (2) FOCI OF INVASIVE DUCIAL.CARCINOMA, NO SPECIAL TYPE. 8.  LARGER TUMOR NOTTINGHAM GRADE 2 (TUBULE FORMATiON 3, NUCLEAR PLEOMORPHISm 2. Mitotic Activity 2; total $cOre: 7/9). C.  SMALLER TUMOR nOTTINGHAM GRADE 2 (TUBULE FORMATION 3. NUCLEAR PLEOMORPHiSM 2. MItotIc activity 1; tOtal Score: 6/9). D.  THE LARGER TUMOR MEASURES 1.7 CM AND IS LOCATED AT 4 O' CLOCK. E  THE SMALLER TUMOR MEASURES O.7 CM AND iS LOCATED AT 5 O' CLOCK. F. DUCTAL CARCINOMA IN SITU (DCIS), NUCI.EAR GRADE 2. SOLID TYPE WITH MINIMAL NECROSIS G.  THE DCIS CONSTITUTES 5% OF THE TOTAL TUMOR MASS AND IS PRE$ENT AWAY FROM THE INVASIVE COMPONENT H. LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.  INKED MARGINS ARE NECATIVE FOR CARCINOMA. HOWEVER, INVASIVE CARCINOMA IS 1.O MM TC THE ANTERIOR MARGIN AND 1 5 MM TO THE POSTERIOR MARGIN (see comment) ATYPICAL DUCTAL HYPERPLASIA. . J. K FLORID DUCTAL EPITHELIAL HYPERPLASIA AND FIBROCYSTIC CHANGES WITH ASSOCIATED MICROCALCIFICATIONS. L PReVIOUS BIOPSy SITE CHANGES. M ONE (1) INTRAMAMMARY I.YMPH NODE, NEGATIVE FOR CARCINOMA (0/1). N. THE INVASIVE TUMOR CELLS ARE POSITIVE FOR ESTROGEN AND PROGESTERONE RECEPTORS AND NEGATIVE FOR HER-2 (FISH NOT AMPi_IFIED) AS PER PREVIOUS PATHOLOGY REPORT PArt 2: SENTINEL Lymph nODE #1. RIgHT AXILLA, BiOPSy 1cs-0 - 3 ONE (1) LYMPH NODE NEGATIVE FOR METASTATIC CARCINOMA (0/1). earcn o7un nfttnstHhy ouutal,nos 950of3 PART 3: SENTiNEL LymPH NODE #2. RIGHT AXiLLA, BIOPSY SHe bruot,Nos C50.9 3J/3/u h One (1) LyMPH NODE NEGATIVE fOR METASTATIC CARCiNOMA (0/1) PART 4: SENTINEL LYMPH NODE #3. RIGHT AXILLA. BIOPSY ONE (1) LYMPH NODE NEGATIVE FOR METASTATIC CARCINOMA (0/1) PART 5: RIGHT BREAST, 5 O' CLOCK. NEW MEOIAL MARGIN, EXCISION  NO CARCINOMA SEEN B. BENIGN BREAST PARENCHYMA WITH FIBROCYSTIC CHANGES. UUID:C6B0D463-9389-4BAE-93CA-3EE4717D20EC TCGA-BH-A0EB-01A-PR  Redacted 37!B7 n
\ No newline at end of file
diff --git a/output/text/2c32ada3-7f8a-4a96-a952-b46744b5f83f.txt b/output/text/2c32ada3-7f8a-4a96-a952-b46744b5f83f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8ad67a0a391d4837c9bfcce74a83ab2bdf9bb552
--- /dev/null
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+--- Page 1 ---
+/cs-0-3 Carcinome, mfittrathny ductel, nos 8500/3 Phone StE: braot, Nos c50.9 1/27/n Specimen: Received: Status: Req#: Spec Type: Subm Dr: RIGHT BREAST CANCER INVASIVE DATE: DOctoR(s) : PROCEDURE: A.  RT BREAST PARTIAL MASTECTOMY UUID:E339A88E-3839-465A-9545-FBA4F79727CC B. RT BREAST MEDIAL RE-EXCISION TCGA-A2-A0T3-01A-PR Redacted c. RT BREAST SENTINEL NODE #1 D. RT BREAST SENTINEL NODE #2 PART A RECEIVED FRESH LABELED RIGHT BREAST PARTIAL MASTECTOMY LONG STITCH EQUALS LATERAL SHORT STITCH EQUALS POSTERIOR, IS AN OVOID PORTION OF YELLOW-PINK FIBROFATTY TISSUE MEASURING 6.8 X 6.2 X 3.6 CM.  TWO SUTURES ORIENT THE SPECIMEN. THE MARGINS ARE MARKED AS FOLLOWS: LATERAL ORANGE, SUPERIOR GREEN, MEDIAL RED, INFERIOR BLUE, SUPERFICIAL BLACK, DEEP YELLOW. SECTIONING REVEALS TWO MASS LESIONS. THE SMALLER IS MEDIAL MEASURING 1.5 X 0.9 X 0.9 CM. THE CLOSEST MARGIN IS SUPERFICIAL AT O.5 CM, WITH ALL OTHER MARGINS GREATER THAN 1 CM. SECOND IS LATERAL AND MEASURES 1.6 X 1.5 X 2.3 CM. THE THE CLOSEST MARGIN IS SUPERFICIAL TOWARD THE LATERAL BORDER, WHERE IT IS O.5 CM FROM THIS MARGIN AND O.5 CM FROM THE SUPERFICIAL MARGIN SUPERIORLY. A RIBBON CLIP IS IDENTIFIED IN THE MORE LATERAL ASPECT OF THE SPECIMEN. TISSUE IS TAKEN FROM BOTH NODULES PER PROTOCOL. SECTIONS ARE SUBMITTED AS FOLLOWS: A1--PERPENDICULAR MEDIAL MARGIN; A2--PERPENDICULAR LATERAL MARGIN; A3--PERPENDICULAR LATERAL LESION WITH SUPERFICIAL MARGIN LATERALLY; A4--LATERAL LESION WITH SUPERFICIAL MARGIN SUPERIORLY; A5--MIRROR IMAGE OF THE AREA TAKEN PER PROTOCOL OF THE LARGER TUMOR TO INCLUDE SUPERFICIAL MARGIN; A6 THROUGH A8--THE REMAINDER OF THIS CROSS-SECTION TO INCLUDE THE INFERIOR, DEEP AND SUPERIOR MARGINS, RESPECTIVELY; A9 AND 1O--FULL CROSS-SECTION OF LATERAL LESION TO INCLUDE SUPERFICIAL MARGIN; A11 THROUGH A14--FULL CROSS-SECTION TO INCLUDE THE MORE MEDIAL SMALLER LESION, WITH A11 THE MIRROR IMAGE OF THAT SUBMITTED PER PROTOCOL TO INCLUDE THE SUPERIOR SUPERFICIAL MARGIN.  THE REMAINING CROSS-SECTION IS SUBMITTED AS SUPERIOR DEEP, DEEP INFERIOR AND INFERIOR SUPERFICIAL, RESPECTIVELY. A15 THROUGH A18 IS THE LATERAL PORTION OF THE LESION TO INCLUDE THE LESION WITH THE SUPERFICIAL SUPERIOR MARGIN, THE SUPERIOR DEEP MARGIN, THE DEEP INFERIOR MARGIN AND THE INFERIOR SUPERFICIAL MARGIN, RESPECTIVELY. A19 IS A FIRM AREA BETWEEN THESE TWO NODULES GREATER THAN 1 CM FROM ALL MARGINS MEASURING 1 X 1 X 0.4 CM. A2O IS THE TISSUE BETWEEN BLOCK A19 AND THE MOST LATERAL LARGER LESION WHICH IS GROSSLY UNREMARKABLE.
+
+--- Page 2 ---
+Patiane! Specimen: Received: Status: Req#: Spec Type: SURGICAL P Subm Dr: (Continued) PART B RECEIVED FRESH LABELED RIGHT BREAST MEDIAL REEXCISION STITCH AT NEW MARGIN, IS AN OVOID PORTION OF YELLOW FATTY TISSUE WITH FOCAL BLUE DYE MEASURING 4.9 X 2.8 X 1.5 CM. A SUTURE DENOTES A NEW MARGIN, AND THIS SIDE IS MARKED WITH BLUE INK WITH A PERIMETER OF BLACK INK, SECTIONED AND SUBMITTED LABELED B1 THROUGH 5. PART C  RECEIVED FRESH LABELED RIGHT BREAST FIRST SENTINEL NODE HOT AND BLUE, IS A 1.8 X 1.2 X 0.9-CM OVOID PORTION OF YELLOW FATTY TISSUE.  SECTIONING REVEALS A 1.1-CM LYMPH NODE WITH BLUE DYE. ONE-HALF IS SUBMITTED PER PROTOCOL. THE REMAINDER IS SUBMITTED LABELED C. PART D RECEIVED FRESH LABELED RIGHT BREAST SECOND SENTINEL NODE BLUE, IS A 1.5 X 1.0 X 0.7-CM OVOID PORTION OF PINK-TAN TISSUE AND ADJACENT YELLOW FAT. SECTIONING REVEALS A GROSSLY FAT-REPLACED LYMPH NODE WITH FOCAL BLUE DYE MEASURING 1.1 CM IN DIAMETER. ONE-HALF IS SUBMITTED PER PROTOCOL.  THE REMAINDER IS SUBMITTED LABELED D. PROCEDURES : 88307/4, IMMUNOPEROXIDAS/2, A BLK/20, B BLK/5, CBX X6, DBX X6 PART A  RIGHT BREAST, PARTIAL MASTECTOMY: .. IN SITU AND INFILTRATING DUCT CARCINOMA WITH TWO SEPARATE NODULES OF INFILTRATING DUCT CARCINOMA PRESENT IN THE SPECIMEN. THE LARGER( (1.7 CM)/NODULE IS POORLY DIFFERENTIATED, NUCLEAR GRADE III/III WITH A HIGH MITOTIC INDEX.S FOCAL DUCT CARCINOMA'EN*SITU WITH COMEDONECROSIS IS PRESENT ASSOCIATED WITH THIS LESION AND BXTEMDENG INTO BRRAST FAT AT LEAST, L.5: CM FROM THE TUMOR. THE SECOND((1.2 CM)/LESION IS MODERATELY DIFFERENTIATED, NUCLEAR GRADE III/III WITH A HEGH MITOTIC INDEX.  THIS LESION IS ALSO ADMIXED WITH AREAS OF HIGH-GRADE DUCT CARCINOMA IN SITU OF THE CRIBRIFORM, MICROPAPILLARY, AND COMEDOCARCINOMA TYPES. INVASIVE CARCINOMA IS LOCATED 3 MM FROM THE SUPERFICIAL MARGIN ON THE LATERAL SIDE. THERE IS A MICROSCOPIC FOCUS OF SOLID TYPE DUCT CARCINOMA IN SITU AT THE MEDIAL MARGIN. DUCT CARCINOMA IN SITU INVOLVES THE SUPERIOR MARGIN AND THERE IS A MICROCALCIFICATION WITH COMEDONECROSIS SUSPICIOUS FOR DUCT CARCINOMA IN SITU AT THE INFERIOR MARGIN, ALTHOUGH THE POSSIBILITY THAT THIS IS A DETACHED ARTIFACTUALLY DISPLACED FOCUS OF DCIS CANNOT BE TOTALLY EXCLUDED.  THE DEEP MARGIN IS FREE OF TUMOR BY AT LEAST 1 CM. PART B RIGHT BREAST MEDIAL MARGIN, REEXCISION: FATTY BREAST TISSUE WITH NO RESIDUAL TUMOR IDENTIFIED. PART C  RIGHT FIRST AXILLARY SENTINEL LYMPH NODE BIOPSY:  METASTATIC INFILTRATING DUCT CARCINOMA IDENTIFIED IN THE SUBCAPSULAR PORTION OF THE
+
+--- Page 3 ---
+Specimen: Received: Status: Req#: Spec Type: SURGICAL P Subm Dr: (Continued) LYMPH NODE WITH SEVERAL FOCI PRESENT.  THE LARGEST CONTIGUOUS FOCUS OF TUMOR SPANS A DISTANCE OF APPROXIMATELY 1 MM. THE TUMOR IS VISIBLE ON BOTH ROUTINE H&E AND CYTOKERATIN IMMUNOHISTOCHEMICAL STAIN. PART D RIGHT SECOND AXILLARY LYMPH NODE BIOPSY:  LYMPH NODE WITH NO EVIDENCE OF METASTATIC DISEASE, SUPPORTED BY NEGATIVE CYTOKERATIN IMMUNOHISTOCHEMISTRY. 1 Signed (prelim.) (signature on file)
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diff --git a/output/text/2c7145d5-5a2e-4ba2-a1e0-ae36de6016d0.txt b/output/text/2c7145d5-5a2e-4ba2-a1e0-ae36de6016d0.txt
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index 0000000000000000000000000000000000000000..eb0831ad87f866ed5bf9d1e390bce8471c7f635a
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+ICs-0-3 Carmmx,mfi(tnnHnj duct nd mutui nu 8553f3 S,ta Cdh: buut, Nos c50.9 1/17 Patient ~ Surgical Pathology: Additional Info. UUID: 267F1EFD-AB89-4124-B803-00CC0E8E9CD2 Surg Path TCGA-B6-A0IN-01A-PR Redacted CLINICAL HISTORY: Breast carcinoma x 2. GROSS EXAMINATION: A. "Reexcision right lateral breast, long suture lateral, short suture superior", received fresh and placed in formalin. The specimen is a 10 x 5.5 x 3 cm predominantly fatty tissue specimen with a 6 x 1 cm skin ellipse with a well healed central linear scar. The specimen is inked blue anteriorly. black posteriorly, and red superiorly in accordance with the short and long sutures. The specimen is serially sectioned to reveal a 2 x 2.2 x 0.7 cm indurated white fibrotic area most consistent with biopsy cavity with additional fibrofatty tissue and no abdominal masses is present. The area containing the biopsy cavity is submitted in toto in Blocks Al-A8. Additional medial tissue is submitted in Blocks A9-Alo (please refer to 1 for specific location in biopsy). B. "Right breast biopsy, long suture lateral, short suture superior", received fresh and placed in formalin. The specimen is 72.4 gram, 8.5 x 6.2 x 2.5 cm excision of breast tissue with a triangular skin resection measuring 5.2 x 1.5 cm. The specimen is inked blue anteriorly, black posteriorly, red superiorly and sectioned from medial to lateral to reveal a 2.2 x 2.1 x 1.1 cm white-tan and white irregular nodule which approaches the initial posterior margin of resection grossly. The tissue medial to the mass is submitted in Blocks B1-B2 and the tissue containing the mass is submitted from medial to lateral in toto in Blocks B3-b9 (refer to mammogram for specific location). An additional section of uninvolved Iateral tissue is submitted in Block Bio. Additionally there is a free floating fragment of predominantly fatty tissue with a suture which measures 4 x 3.5 x 0.7 (designated new posterior margin per surgeon). The portion of tissue containing the suture is Block Bll. Tissue is submitted fresh for estrogen and progesterone receptors. Dr. DIAGNOSIS: A. "RE-EXCISION RIGHT LATERAL BREAST", (RE-EXCISION) : INTERMEDIATE GRADE DUCTAL CARCINOMA IN SITU. NO EVIDENCE OF INVASIVE CARCINOMA. TYPE OF IN SITU CARCINOMA: CRIBRIFORM AND SOLID, WITH EXTENSIVE LOBULAR CANCERIZATION. SIZE OF IN SITU CARCINOMA, 2.2 CM. STATUS OF NON-NEOPLASTIC BREAST TISSUE: STROMAL FIBROSIS, AND CHANGES CONSISTENT WITH PRIOR BIOPSY SITE. MICROCALCIFICATIONS PRESENT, IN ASSOCIATION WITH DUCTAL CARCINOMA IN SITU. SURGICAL MARGIN STATUS, POSITIVE MULTIFOCALLY FOR DUCTAL CARCINOMA IN SITU. B. "RIGHT BREAST*, (STEREOTACTIC NEEDLE BIOPSY): INFILTRATING DUCTAL ADENOCARCINOMA. SEE COMMENT.S N.S.A.B.P. NUCLEAR GRADE 2-3 OF 3. N.S.A.B.P. HISTOLOGIC GRADE 3 OF 3. GROSS TUMOR SIZE, 2.2 CM. SIZE OF INVASIVE COMPONENT, 1.6 CM. LYMPHATIC/VASCULAR INVASION, ABSENT. MULTIFOCAL TUMOR, NO. DUCTAL CARCINOMA IN SITU PRESENT, OCCUPYING 2O% OF TUMOR.S 1 of 3
+
+--- Page 2 ---
+TYPE OF IN-SITU CARCINOMA, CRIBRIFORM AND SOLID. STATUS OF NON-NEOPLASTIC BREAST TISSUE: PROLIFERATIVE FIBROCYSTIC CHANGES. SKIN AND MUSCLE, WITHOUT SIGNIFICANT HISTOLOGIC ABNORMALITIES.S MICROCALCIFICATIONS, ABSENT. SURGICAL MARGIN STATUS (SEE COMMENT). ESTROGEN/PROGESTERONE RECEPTOR AND CELL CYCLE ANALYSIS: PENDING. METHODOLOGY: IMMUNOHISTOCHEMISTY, PARAFFIN BLOCK B6. RESULTS WILL BE ISSUED IN AN ADDENDUM. commEnr: Intraductal carcinoma is seen at the posterior inked surgical margin of resection in part "p". However, the region further designated as "new" posterior margin is negative for tumor. Focal mucinous differentiation is present in the main invasive tumor mass (part "b"). However, this represents a minority of the invasive component which otherwise is poorly-differentiated. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es). -M.D. Electronicalfy signe-. ADDENDUM 1: Tissue was sent to the for assay of the estrogen and progesterone receptors. The estrogen receptor activity was judged to be positive with an estimated FmoL value of S4. The progesterone receptor activity was judged as negative with an estimated Fmol value of 0.  Please refer to for a complete report. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es).. Electronically signea.. ADDENDUM 2: HER2/neU IMMUNOHISTOCHEMICAL ANALYSIS Immunostaining for HER2/neu (c-erbB-2) oncoprotein is performed on recut sections of block B7. The tumor cells exhibit staining of their cell membrane (score 2+), indicating that they do overexpress HEr2/neu oncoprotein. METhoD: The immunostaining is done using DAko rabbit anti-human c-erbB-2 oncoprotein which is an affinity-isolated antibody I. The immunostaining is performed after antigen retrieval by heating the unstained sections at 95 degrees centigrade for 20 minutes in 10 mM citrate buffer, pH 6.0. The primary antibody is used at a dilution of 1:30oo (manual staining). with an incubation for one hour at 37 degrees centigrade. The Histostain Plus kit is used as the detection system. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es).. Electronically signed CI ADDENDUM 1: COMMENT: This addendum is issued to report the results of HER2/neu FISH analvsis performed at in the HER2/neu FisH analysis performed at on the same block. 2 of 3
+
+--- Page 3 ---
+ HER2/NEU FISH ANALYSIS REsuLts: Fluorescence in situ hybridization (FIsh) with probes for the HER2/neu region of chromosome 17 (17q1l.2q12) and the centromere of chromosome 17 (D17z1) was performed on block B7. The HER2/neu and centromere 17 signals were enumerated in 60 nuclei from an invasive area of the tumor located by comparison with the hematoxylin and eosin stained adjacent section. The HER2/neu to centromere 17 ratio was 2.00 +/- 0.89 (mean +/- 1 s.D.). For comparison, analysis at a ratio of 2.18. INTERPRETATION: This specimen IS NOT AMPLIFIED for the HER2/neu gene. A HER2/neu to D17z1 ratio greater than 2.00 usually indicates HER2/neu gene that the result Is Nor significantly greater than 2.00. Most nuclei had 2 copies of the chromosome 17 centromere and 3 copies of the HER2/neu gene. METHoDOLOGy: The PathVysion Her2 DNA Probe Kit was used to obtain these results. The PathVysion HER2 DNA Probe Kit is designed to detect amplification of the HEr2/neu gene via fluorescence in situ hybridization (FIsh) in formalin-fixed paraffin-embedded human breast cancer tissue specimens. The use of these Fish probes has been approved by the U.s. Food and Drug Administration. This test is not intended to screen for or diagnose breast cancer. and pathologic information currently used for the prognosis of breast cancer patients. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es). Electfonically: eBrowser Re! 3 of 3
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diff --git a/output/text/2cad6db7-4bb7-4b99-9b46-a33d44afc35c.txt b/output/text/2cad6db7-4bb7-4b99-9b46-a33d44afc35c.txt
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index 0000000000000000000000000000000000000000..a9ed55244d75d47ca8ba52227f57d166120bc7a5
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+
+--- Page 1 ---
+UUID:FFC32668-B801-48EB-BBAC-0E624AEED12D TCGA-DK-A6AW-01A-PR Redacted SURGICAL PATHOLOGY REPORT Patient Name: Accession #: Med. Rec. #: Date of Procedure: DOB:  Location: (Age Date of Receipt: Gender: Service:  Urology Date of Report: Ref. Physician: Account #: Patient Address: Billing Type: INPATIEN Additional Copy to: Ref. Source: N6S Clinical Diagnosis & History: 8/20/3 Bladder carcinoma. Specimens Submitted: 1: SP: Right pelvic lymph nodes, excision (fs) potr Badder, Luretirie oryieei 2: SP: Perivesical tissue, excision 3: SP: Right pelvic lymph nodes, excision C69.6 4: SP: Left pelvic lymph nodes, excision O 6fl 3 5: SP: Bladder, prostate, seminal vesicles, urethra, perivesical tissue and lymph nodes, radical cystoprostatectomy 6: SP: Left pelvic lymph nodes, excision 7: SP: Right pelvic lymph nodes, excision 8: SP: Left vas deferens, excision 9: SP: Lipoma of left spermatic cord 10: SP: Right vas deferens, excision 11: SP: Urachus, excision 12: SP: Distal right ureter, excision DIAGNOSIS: SP: Right pelvic lymph nodes, excision (fs): Lymph Nodes: Not involved Number of nodes examined:7 2. SP: Perivesical tissue, excision: - Benign fibroadipose tissue. SP: Right pelvic lymph nodes, excision: Lymph Nodes: Not involved Number of nodes examined:3  SP: Left pelvic lymph nodes, excision: Lymph Nodes: Not involved Number of nodes examined:2 5.  SP: Bladder, prostate, seminal vesicles, urethra, perivesical tissue and lymph nodes, radical cystoprostatectomy: Tumor Type: Invasive urothelial carcinoma, NOS Histologic Grade:  High grade Page 1 of 7
+
+--- Page 2 ---
+SURGICAL PATHOLOgy REPORT Pattern of growth of the Non-Invasive component: Flat (in situ carcinoma) Pattern of growth of the Invasive component:  Infiltrating Tumor Multicentricity:  Not identified Bladder Local Invasion:  Superficial half of muscularis propria. Extravesicaf Tumor Extension: ".?" , Ureters uninyolved. : Jascular Invasion: . Not'identified : .Rerinewral Invasion: Notidentified Surgical Margins: Free of tumor Non-Neoplastic Mucosa: Exhibiting granulomatous cystitis Prostate: Nodular hyperplasia Seminal Vesicles: Not involved Perivesical Lymph Nodes: Not identified The Pathologic Stage is (AJCC 2002):  pT2a (Invades superficial half of muscularis propria) PR0 (No involvement of prostate) 6.  SP: Left pelvic lymph nodes, excision: Lymph Nodes: Number of nodes examined:13 Number of metastatic nodes:0 7. SP: Right pelvic lymph nodes, excision: Lymph Nodes: Number of nodes examined:2 Number of metastatic nodes:0 8. Left vas deferens, excision: - Benign vas deferens. 9.  Lipoma of left spermatic cord; excision: - Benign fibroadipose tissue.. 10. Right vas deferens, excision: - Benign vas deferens. Page 2 of 7
+
+--- Page 3 ---
+SURGICAL PATHOLOGY REPORT 11.  Urachus; excision: - Benign fibroadipose tissue. 12. Distal right ureter; excision: - Benign ureter. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Gross Description: 1) The specimen is received fresh for intraoperative consultation, labeled "right pelvic lymph nodes " and consists of two pink tan fatty lymph nodes (1.5 and 6.5 cm in greatest dimension) which are bisected and submitted for frozen section (FSA: one lymph.  node; FsB-FSD: one trisected lymph node). Possible smaller lymph nodes (0.5-0.8 cm) are identified and submitted for paraffin sections. Summary of sections: FSCA - frozen section control FSCB - frozen section control FSCC - frozen section control FSCD - frozen section control LN - lymph nodes 2). The specimen is received fresh, labeled "perivesical tissue, fresh and sterile" and consists of a single ovoid portion of pink-tan. to yellow-tan, lobulated fibroadipose tissue measuring 7 x 4 x 1.2 cm with no lymph nodes grossly identified. Representative. sections are submitted.. Summary of sections:  U -- undesignated 3). The specimen is received fresh, labeled "right pelvic lymph nodes, fresh and sterile" and consists of three pink tan firm lymph. nodes ranging from 1 to 3.7 cm in greatest dimension.  All identified lymph nodes are submitted. Summary of sections: LN -- lymph node TLN -- trisected lymph node QLN -- quadrisected lymph node 4). The specimen is received fresh, labeled "left pelvic lymph nodes, fresh and sterile" and consists of two pink tan firm lymph.  nodes measuring 1.9 and 2.9 cm in greatest dimension. All identified lymph nodes are submitted. Summary of sections:. LN -- lymph node BLN -- bisected lymph node Page 3 of 7
+
+--- Page 4 ---
+SURGICAL PATHOLOGY REPORT 5) The specimen is received fresh labeled, "Bladder, prostate, seminal vesicles, urethra, perivesical tissue and lymph nodes". It. consists of a cystoprostatectomy specimen measuring 18.5 cm from superior to inferior, 7.5 cm laterally and 5.0 cm from anterior to posterior.  The left prostate is inked blue and the right prostate is inked green and the remainder of the specimen is inked magenta. The prostatic urethral margin is shaved and submitted. The bladder is opened along the anterior midline to reveal two polypoid tumors measuring 2.5 x 1.9 x 1.2 cm (t1) and 1.4 x 1.3 x 0.8 cm (t2). T1 is grossly situated adjacent to the opening of the. prostatic urethra, 0.6 cm from the right ureter. T2 is grossly situated on the left side and is partially occluding the left ureteral orifice. Both ureters are probe patent measuring 0.6 (right) and 1.1 cm (left) in maximum diameter. The lesion is sectioned to reveal no invasion beyond the base of the polyp. Extension to the inked fat is grossly not identified. The remaining bladder mucosa is. ulceration and congestion at the trigone. Discrete perivesical lymph nodes are grossly not identified. The prostate is serially sectioned to reveal multiple BPH nodules..  Representative sections are submitted including two sections from each prostatic quadrant and transition zone. TPS is submitted. Summary of sections: UTHM -- urethral margin RUM-- right ureter margin LUM -- left ureter margin T1RUO -- right ureter orifice T2LUO-- entire T2 and entire left ureteral orifice LP -- left posterior wall! LA -- left anterior wall RP -- right posterior wall RA-- right anterior wall TRI -- trigone DOM-- dome F -- perivesical fat RSV -- right seminal vesicle- LSV -- left seminal vesicle RAP -- right apex prostate LAP -- left apex prostate RAM -- right anterior mid prostate RPM -- right posterior mid prostate. LAM -- left anterior mid prostate LPM -- left posterior mid prostate RAB -- right anterior base prostate RPB -- right posterior base prostate LAB -- left anterior base prostate LPB -- left posterior base prostate 6). The specimen is received fresh, labeled "left pelvic lymph nodes" and consists of multiple pink tan firm lymph nodes ranging from 0.3 to 3.9 cm in greatest dimension.  All identified lymph nodes are submitted. Summary of sections: LN -- lymph nodes BLN-- bisected lymph nodes 7). The specimen is received fresh, labeled *right pelvic lymph nodes" and consists of multiple pink tan firm lymph nodes ranging from 0.3 to 0.5 cm in greatest dimension.  All identified lymph nodes are submitted. (The entire specimen is submitted) Summary of sections: LN -- lymph nodes BLN-- bisected lymph nodes Page 4 of 7
+
+--- Page 5 ---
+SURGICAL PATHOLOGY REPORT 8). The specimen is received in formalin, labeled "Left vas deferens" and consists of an unoriented segment of pink-tan tubular  tissue measuring 8.7 cm in length and 0.3 cm in maximum diameter, with scant yellow-tan soft tissue attached. On cut section, a pinpoint lumen is identified. No discrete abnormalities are grossly noted. Representative sections of the specimen are submitted. Summary of sections: E - ends C - center 9). The specimen is received in formalin, labeled "Lipoma of left spermatic cord" and consists of a formed mass of yellow-tan Iobulated soft tissue measuring 6.2 x 3 x 0.9 cm. The external surface covered by a thin transparent membrane. Sectioning  reveals yellow-tan lobulated and grossly unremarkable soft tissue. Representative sections are submitted. Summary of sections: U-undesignated 10). The specimen is received in formalin, labeled "Right vas deferens" and consists of an unoriented segment of pink-tan tubular tissue measuring 4.7 cm in length and 0.3 cm in maximum diameter, with scant yellow-tan soft tissue attached. On cut section, a  pinpoint lumen is identified. No discrete abnormalities are grossly noted. Representative sections of the specimen are submitted. Summary of sections: E - ends C - center 11). The specimen is received in formalin, labeled "Urachus" and consists of a piece of focally hemorrhagic fatty tissue measuring 7.5 x 2.8 x 1.0 cm.  Sectioning reveals no definitive urachus.  The specimen is serially sectioned from end to end and is entirely submitted. Summary of sections: Ss -- serial sections 12). The specimen is received in formalin, labeled "Distal right ureter" and consists of a segment of ureter measuring 2.9 cm in length and 0.5 cm in maximum diameter, with attached adipose tissue.  A clip is identified at one end, which marks the proximal margin and is inked black. The specimen is serially sectioned to reveal a patent stellate lumen with no abnormalities grossly  noted. The specimen is serially sectioned from the unclipped to clipped end, and is entirely submitted. Summary of sections: C-clipped end, margin SS-serial sections clipped to opposite unclipped end. OE -- opposite unclipped end. Summary of Sections: Part 1:  SP: Right pelvic lymph nodes, excision (fs). Block Sect. Site PCs 1 fsca 1 fscb 1 1 fscc 1 fscd 1 1 In 1 Part 2: SP: Perivesical tissue, excision Block Sect. Site PCs  Page 5 of 7
+
+--- Page 6 ---
+SURGICAL PATHOLOGY REPORT 2 U 20 Part 3:SP: Right pelvic lymph nodes, excision. Block Sect. Site PCs 1 LN 1 4 QLN 4 3 TLN Part 4:  SP: Left pelvic lymph nodes, excision PCs Block Sect. Site 2 BLN 2 1 LN 1 Part 5:  SP: Bladder, prostate, seminal vesicles, urethra, perivesical tissue and lymph nodes, radical cystoprostatectomy Block Sect. Site PCs  dom 1 1 1 f 1 1 la 1 1 lab 1 1 lam 1 lap 1 1 Ip 1 1 lpb 1 1 Ipm 1 1 Isv 1 1 lum 1 1 ra 1 1 rab 1 1 ram 1 1 rap 1 1 rp. 1 1 rpb 1 1 rpm 1 1 rsv 1 1 rum 1 5 t1ruo 5 5 t2|uo 5 1 tri 1 1 uthm 1 Part 6:  SP: Left pelvic lymph nodes, excision Block Sect. Site PCs 4 bln 4 4  Ign 4 3 In 3 Part 7:  SP: Right pelvic lymph nodes, excision Block Sect. Site pCs 1 bln 1 1 In 1 Part 8: SP: Left vas deferens, excision. Block Sect. Site PCs 1 c 1 Page 6 of 7
+
+--- Page 7 ---
+SURGICAL PATHOLOGY REPORT e 1 Part 9:SP: Lipoma of left spermatic cord Block Sect. Site pCs 3 ss 3 Part 10:SP: Right vas deferens, excision Block Sect. Site PCs 1 c 1 1 e 1 Part 11: SP: Urachus, excision Block Sect. Site PCs 6 ss 6 Part 12:SP: Distal right ureter, excision Block Sect. Site PCs 1 c 1 1 oe 1 1 ss 1 Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 1A-D. FROZEN SECTION DIAGNOSIS:  SP: RIGHT PELVIC LYMPH NODES (FS): nEGATIVE LYMPH NODES PERMANENT DIAGNOSIS: SAME ,MD  Page 7 of 7 END OF REPORT
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diff --git a/output/text/2cba040f-bb76-43af-8de7-ed83174b4b7f.txt b/output/text/2cba040f-bb76-43af-8de7-ed83174b4b7f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9ec6ed55151f6687f1f9185916f4d00f24bd3eb1
--- /dev/null
+++ b/output/text/2cba040f-bb76-43af-8de7-ed83174b4b7f.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+TCGA-A6-2675 SPECIMEN Sigmoid colon CLINICAL NOTES PRE-OP DIAGNOSIS: Sigmoid cancer GROSS DESCRIPTION Received fresh, subsequently fixed in formalin labeled "sigmoid colon" is a 17 cm. long portion of colon which is opened on both ends. The serosa is pink-tan smooth glistening and the specimen is predominantly covered with abundant yellow lobular fat and pink-tan smooth glistening serosa. The specimen is opened to show pink-tan smooth glistening mucosa with an average. circumference of 4 cm. The specimen shows a 3.2 x 2.5 x 0.5 cm. tumor which shows. ulcerated center and raised borders. The cut surface of this shows gross invasion into the muscularis propria and comes within 7.5 cm.. of the radial margin; however, there 'is an umbilication near the serosa and the fat meet. This is inked and the tumor comes within 0.7 cm. of this area. No other discrete gross lesions are. identified. Lymph nodes are grossly identified in the fat.. Representative sections of the specimen are submitted as follows: BLOck summARy: 1 - representative luminal margins; 2 - representative section of tumor to fat and serosa; 3-5 - additional representative sections of tumor to fat; 6 - representative radial. margins; 7 - 4 possible lymph nodes; 8 - 6 possible lymph nodes; 9 6 possible lymph nodes; 10 - 3 possible lymph nodes. Rs-10 MICROSCOPIC DESCRIPTION Histologic type: Adenocarcinoma.. Histologic grade: Moderately differentiated.. Primary tumor (pT) : Tumor invades through the muscularis propria. to
+
+--- Page 2 ---
+MICROSCOPIC DESCRIPTION the junction of the muscularis propria and serosa (pT3). Proximal margin: Negative.. Distal margin: Negative.. Circumferential (radial) margin: Negative. Vascular invasion: Negative.. Regional lymph nodes (pN): Eleven mesenteric lymph nodes are negative for metastatic carcinoma (pN0).. Non-lymph node pericolonic tumor: Absent Distant metastasis (pM): Cannot be assessed (pmx).. 5 DIAGNOSIS Colon, sigmoid, segmental resection:. Invasive moderately differentiated colonic adenocarcinoma extending through the muscularis propria to the junction of the muscularis propria and serosa.. Proximal, distal and radial margins of resection are free of tumor. Eleven mesenteric lymph nodes negative for metastatic carcinoma (0/11).
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diff --git a/output/text/2cbcca10-329d-40cc-a323-7615cea04215.txt b/output/text/2cbcca10-329d-40cc-a323-7615cea04215.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4674595bbd26a90f00334d1b635a8d3d486d4782
--- /dev/null
+++ b/output/text/2cbcca10-329d-40cc-a323-7615cea04215.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:69FF5548-F180-452F-B77B-405479A5993D TCgA-22-A9j0-01a-pr Redacted arrityi yjellar ceQQ 8 8Q60/3 Pathology Report 28/ Final Diagnosis A. RIGHT KIDNEY, PARTIAL NEPHRECTOMY: Renal cell carcinoma with hybrid oncocytic features and focal papillary features. See Key Pathoiogic Findings. Surgical margin, free of malignancy. Patho!ogic stage: pT1b NX MX B. DEEP MARGIN: Renal parenchyma, free ot malignancy. the attending pathologist, personally reviewed all siides and / or materials and rendered the final diagnosis. Electronically Signed out by . Ancillary Testing Immunohistochemical stains (AMACR, cytokeratin 7, cytokeratin 20, CD117, vimentin) performed with. appropriate positive and negative controls on blocks A3 and A5 support the diagnosis. Immunohistochemical stain (RcC antigen) performed with appropriate positive and negative control on. block A5 supports the diagnosis. Special stain (Hale's colloidal iron) performed with appropriate. control on block A5 supports the diagnosis.. Key Pathological Findings A: Kidney Resection PROCEDURE: Partial nephrectomy SPECIMEN LATERALITY: Right TUMOR SiZE (iargest tumor if muitiple): Dimension: 4.5 cm MACROSCOPICEXTENT OF TUMOR: Tumor limited to kidney HISTOLOGIC TYPE: Renal cell carcinoma with hybrid oncocytic features and focal papillary features SARCOMATOID FEATURES: Not identified HISTOLOGIC GRADE (Fuhrman Nuclear Grade): G3: Nuclei very irregular, approximately 20 microns; nucleoli large and prominent MICROSCOPIC TUMOR EXTENSION: Tumor limited to kidney MARGINS: Margins uninvolved by carcinoma ADRENAL GLAND: Not present PERINEURAL INVASION: Absent
+
+--- Page 2 ---
+ANGIOLYMPHATIC INVASION: Absentd LYMPH-VASCULAR INVASION: Absent PRIMARY TUMOR (pT): pT1b: Tumor more than 4 cm but not more than 7 cm in greatest dimension, limited to the kidney REGIONAL LYMPH NODES (pN): pNX: Regional lymph nodes cannot be assessed DISTANT METASTASIS (pM) pMX Specimen(s) Received A RIGHT PARTIAL NEPHRECTOMY FS B DEEP MARGIN FS Preoperative Diagnosis Right renal mass Intraoperative Consultation FSA1:  RIGHT PARTIAL NEPHRECTOMY, INK EQUALS MARGIN: Oncocytic lesion, margin negative.. FSB1: DEEP MARGIN, INK IS MARGIN: Negative. Comment: This frozen section diagnosis/result was communicated to and acknowledged by Dr..  have performed the intraoperative consultation and issued the above  diagnosis.e Gross Description  Specimen A is received fresh tor frozen section analysis labeled "right partial nephrectomy ink. 4. equals margin." The specimen consists of a 5.5 x 5.5 x 4.0 cm partial nephrectomy. The surgical margin resection is marked with black ink. Serial sectioning reveals a soft, red-brown mass (4.5 x 4.5. x 3.0 cm) grossty abutting the surgical margin resection. The overlying capsule is intact and marked. with blue ink. The remainder of the renal parenchyma is red-brown and grossly unremarkable.. Representative frozen sections taken and submitted as FSA1. Representative section of the tumor submitted to the Tissue Procurement Laboratory. Permanent representative sections are submitted as: A2: Mirror image of tumor submitted to the Tissue Bank. A3: Tumar shown in its relationship to overtying capsule. A4-A7: Representative sections of tumor showing its relationship to adjacent tissue. AB: Grossty unremarkable renal parenchyma. B. Specimen B is received fresh for frozen section analysis iabeled "deep margin, ink is margin.". The specimen consists of 1.5 x 0.2 x 0.1 cm saft, tan-pink, irregular fragment of renal parenchyma,. which is marked with ink on the surgical margin resection.* The specimen is serially resectioned and. entirely submitted for frozen section as FS81. Criteria /3/y Primary Tumor Site D Dual/Synchronous Prin
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diff --git a/output/text/2ce4f7a3-6838-492d-acd2-ac90c58ab0c4.txt b/output/text/2ce4f7a3-6838-492d-acd2-ac90c58ab0c4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c8681d82b55aa4a21249e31e1bade0d4d1a1ef3b
--- /dev/null
+++ b/output/text/2ce4f7a3-6838-492d-acd2-ac90c58ab0c4.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+ICD-0-3 Carci omn,nfittnutng ductcl, nos 850o/3 4h-site: Brest, uo$,cso.4 1f19/n l cQcc sif:Brust, Nosc5o.9 Diagnosis: 1. Poorly differentiated invasive solid carcinoma, clearly consistent with. a ductal breast carcinoma (maximum reconstructed tumor diameter: 3.0 cm; forming a ventral margin, caudal distance 0.5 cm, lateral 1 cm, cranial 1.2 cm, medial and dorsal 1.5 cm). The tumor-free, ink-stained resection margin of the ventral follow-up resection material (preparation 4) gives rise to the following tumor classification: NOS, G III, pT2 pN0(0/13)L0V0R0. UUID: 9ECA4450-A550-44DE-B2ES-FD1CFF02A9FE Redacted
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diff --git a/output/text/2d0555b5-c464-4021-9de2-94bda4ddfb35.txt b/output/text/2d0555b5-c464-4021-9de2-94bda4ddfb35.txt
new file mode 100644
index 0000000000000000000000000000000000000000..41084386865af01a1dcbe1a8a95ae3e78edb6b4f
--- /dev/null
+++ b/output/text/2d0555b5-c464-4021-9de2-94bda4ddfb35.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID: 2180850C-CC8D-4376-B2EE-1ADC3F5B3EC1 CGA-A7-A13E-01A-PR Redacted 1cs-0 - 3 Careioma- bi#i1frat+ng Duct, NO5 8500|3 M PECIMEN 11j1b/0 A.  Left sentinel node. Sitv: brt, nus c5o.9 B. Left breast tissue. C. Axillary contents CLINICAL NOTES PRE-OP DIAgnosIs: Left breast cancer. CLINICAL HIsToRY: Left breast cancer. FROZEN SECTION DIAGNOSIS FsA) Left sentinel node - Two of three lymph. nodes positive for metastatic carcinoma (2/3). GROSS DESCRIPTION A. Submitted fresh for frozen section as "left sentinel node" are two portions of fatty tissue, the larger of the two is 2 cm. in size, the smaller 1.2 cm. in size. The section through the tissue reveals three small nodules which may be lymph nodes varying in size from 6 mm. to a centimeter. All three submitted for frozen section.. B. Received fresh, subsequently fixed in formalin labeled "left breast tissue" is a 7.8 x 7.5 x 4.0 cm. yellow. lobular fatty tissue fragment which is partially covered with a 4.0 x 1.2 cm. pink-tan wrinkled skin ellipse. The specimen has a long. suture designating lateral and a short suture designating superior. The specimen is inked as follows: Superior orange, anterior blue, posterior black, inferior green and the specimen is sectioned from medial to lateral to show a yellow lobular fatty cut surface with minimal fibrous tissue. There is also a white tan firm nodule which is centrally located, measuring 3.5 x 2.5 x 2.5 cm. This comes within 2 cm. of superior-inferior margin and comes within 1.5 cm. of the anterior and posterior margin. This was located equal distance between the medial and lateral margins. Representative sections of the specimen are submitted as follows: Block 1 - representative GROSS DESCRIPTION medial margin; block 2 - representative lateral margin; block 3-10 representative sections additional margins and skin. Rs-10. C. Received fresh, subsequently fixed in formalin labeled "axillary content" is a 7 x 6 x 1.5 cm. aggregate of. yellow lobular fatty tissue fragments which are palpated to identify possible lymph nodes. Multiple lymph nodes are grossly identified which range from 0.5 cm. to 2.0 cm. in greatest dimension. The lymph nodes are entirely submitted as follows: block 1 - two
+
+--- Page 2 ---
+possible lymph nodes; block 2 - three possible lymph nodes; block 3  two possible lymph nodes; block 4 - one possible lymph node bisected. Rs4. MICROSCOPIC DESCRIPTION A. Sections of the left sentinel lymph nodes demonstrate metastatic carcinoma involving 2 of 3 lymph nodes. The. largest metastasis is 1.2 cm and extracapsular extension is present. B. The following template applies to the left breast. Invasive Carcinoma: Present Histologic type: Infiltrating ductal carcinoma. Histologic grade: Overall grade: 3 Architectural score: Nuclear score: 3 Mitotic score: 3 Greatest dimension: 3.5 cm (pT2) Specimen margins: Negative, nearest 1.3 cm, posteriorly Vessel invasion: Present MICROSCOPIC DESCRIPTION Calcification: Present Ductal carcinoma in situ: Present Histologic pattern: Solid and comedo Nuclear grade: 3 Central necrosis: Present %Dcis of total tumor: Less than 10% Extensive intraductal component (present/absent): Absent Specimen margins: Negative Calcification: Present Description of non-tumorous breast: Proliferative changes. Comments: None Prognostic markers: Previously performed..
+
+--- Page 3 ---
+C. There is no evidence of metastatic disease present in 9 additional left axillary lymph nodes. 14, 4x3 DIAGNOSIS A. Left axillary sentinel lymph nodes, excision: Metastatic carcinoma present in 2 of 3 lymph nodes (2/3).. Size of largest metastasis 1.2 cm. Extracapsular extension present. B. Left breast, excisional biopsy: Infiltrating ductal carcinoma, grade 3, 3.5 cm, margins negative. Ductal carcinoma in situ, grade 2, margins negative.. C. Left axillary contents, resection: No evidence of metastasis in nine lymph nodes (0/9). DIAGNOSIS M.D, (Electronic Signatuse) - End Of Report
\ No newline at end of file
diff --git a/output/text/2d251759-6ea5-4d30-95e7-3ae7f6247e18.txt b/output/text/2d251759-6ea5-4d30-95e7-3ae7f6247e18.txt
new file mode 100644
index 0000000000000000000000000000000000000000..11b57256fb843a35c75fbaf99e114ad46295e605
--- /dev/null
+++ b/output/text/2d251759-6ea5-4d30-95e7-3ae7f6247e18.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Results SURGICAL PATHOLOGY Patlent Info Patient Name Sex DOB Male Results UUID:10CCB12F-77E0-4100-A87A-0D36E5AF7F8B TCGA-IA-A83W-01A-PR Redacted Specimen #: Physician: FINAL DIAGNOSIS RIGHT KIDNEY, EXCISION - RENAL CELL CARCINOMA, PAPILLARY TYPE, FUHRMAN GRADE 2 OF 4 (SEE COMMENT). ALL MARGINS NEGATIVE FOR NEOPLASM.  BENIGN EPITHELIAL CYST. COMMENT The neoplasm measures 5.5 cm in greatest dimension and is situated in the upper pole of the kidney. The tumor invades the overlying renal capsule and is present within 1 mm from the soft tissue margin, however it does not penetrate the capsule into the perirenal fat.   Renal sinus invasion or angiolymphatic invasion are not identified. ***Electronic signature** ********************** * * IcD-o 3 SPECIMEN SUBMITTED A: RIGHT KIDNEY 8Q40h3 CLINICAL DATA C64.9 RIGHT RENAL MASS y j0/7113 GROSS DESCRIPTION A. Received fresh is a specimen consisting of a right kidney surrounded by an envelope of fibroadipose tissue measuring 20.0 x 13.0 x 6.5 cm and weighing 919.34 grams. A mass involves the upper portion of the kidney. On section, the tumor mass is roughly spherical and measures 5.5 cm in greatest dimension. It is composed of yellow to tan soft homogenous tissue. Foci of hemorrhage or necrosis is not present. The tumor does extend into the perirenal fat. The tumor does not invade the pelvicaliceal system or renal sinus. The tumor is sharply demarcated from the renal parenchyma which appears essentially unremarkable. Satellite nodules of tumor are not present. Dissection of the renal veins particularly those draining the area of the mass does not show the intravascular present of a neoplasm. The adrenal gland is not present. An 8.5 cm segment of ureter is present and is essentially unremarkable. Sectioning of the renal parenchyma reveals a cyst measuring 1.5 cm in greatest dimension. Representative sections are submitted as follows: Al ureter margin, A2 vascular margin, A3 pelvis and sinus, A4 cyst, A5-A6 sinus and mass, A7-A1o mass and capsule and soft tissue margin. Page 1 of 2
+
+--- Page 2 ---
+Patient ID #: DOB: Date  of Report: Date of Procedure:. Date of Receipt:. Submitted by: Location: Lab and Collection. SURGICAL PATHOLOGY C )on - Lab and Collection Information. Result History  SURGICAL PATHOLOGY ( ) on -- Order Result History Report.. Result Information Result Date and Time. Status Provider Status Final result Ordered Status: This result is currently not released to Display Full Result Report Display Order Report. 10313 0737 Page 2 of 2
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diff --git a/output/text/2d4df18c-bef2-4136-a50c-96c5b110778f.txt b/output/text/2d4df18c-bef2-4136-a50c-96c5b110778f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6328cf49069eb4cc832defbf4e62ce320f9aea56
--- /dev/null
+++ b/output/text/2d4df18c-bef2-4136-a50c-96c5b110778f.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:265E5A9A-64FD-4B86-89BC-5E89F253C118 TCGA-3C-AAL3-01A-PR Redacted Name: Path No.: MRN: Date Obtained: D.O.B. (Age Date Received: Sex: F Physlcian: Location: SURGICAL'PATHOLOGY tDO-3 sueironsy ainfiltatint letNos SPECIMEN: 6 s0 |8 Breast, right, skin sparing modified radical mastectomy Buaet c so9 Baxt,snoWirc &80.8 DIAGNOSIS(ES): QO s4 Breast, right, skin sparing modified radlcal mastectomy: Invasive ductal carcinoma, pooriy differentiated (Modified Scarff Bloom Richardson Score 3+3+2=8/9), multifocal, with lymphatic invasion. Metastatic carcinoma in 1/23 axillary lymph nodes (See microscopic description) pT2N1 CLINICAL. INFORMATION: Right breast cancer. GROss DESCRIpTION: The specimen is received unfixed in a container labeled with the patient's name and "Right breast mastectomy". It consists of a right rnodified mastectomy specimen measuring 24.0 x 20.0 x 5.2 cm. A suture is noted indicating the axillary tail. The overlying.skin measures 14.5 x 8.0 cm. The nipple is mobile and everted. An underlying mmass is palpable in the 6 o'ciock position. The deep (fascial) margin is inked black and the rernaining margins are inked yellow. The axillary tissue measures 11.0 x 6.5 x 2.0 cm. Multiple lymph nodes are palpable within it measuring from 0.5 cm to 1.7 crm in greatest dimension. The lymph nodes are dissected, proceeding from the breast toward the axilla. The specimen is serially sectioned at closely spaced intervals revealing a firm, poorly circumscribed, white and focally hemorrhagic mass measuring 3.5 x 3.0 x 2.0 cm located in the inferior aspect of the specimen (6 o'clock position). The mass comes to within 0.8 cm of the skin and 3.0 cm of the deep margin. A second firm, well circumscribed mass measuring 0.7 x 0.5 x 0.5 is also identified located located 0.8 cm from the skin, 2.4 cm from the deep margin and 2.0 cm from the previously described mass, superiorly. The parenchyma superior and lateral to both masses is firm, Iobulated and gritty over an area measuring 4.0 x 3.5 x 2.0 cm. The remaining tissue is cornposed of a rnoderate amount of breast tissue and a moderate amount of yellow fatty tissue. Representative sections are submitted in 37 cassettes labeled A1-A37. Please note: The specimen was placed in formalin at LEGEND: A1-A3 = Nipple A4 = Deep margin closest to main mass A5 = Main mass with closest skin A6-A8 = Main mass A9-A10 = Smaller mass A11 = Smaller mass with closest skin A12 = Deep margin closest to smaller mass Page l of 3
+
+--- Page 2 ---
+A13-A18 = Gritty area surrounding masses A19-A20 = Upper inner quadrant A21-A22 = Lower inner quadrant A23-A24 = Lowsr outsr quadrant A25-A26 = Upper outer quadrant A27 = Bisected lymph node closest to breast A28 =3 intact nodes A29 = 3 intact nodes A30 = 1 bisected node A31 = 1 bisected node A32 = 1 bisected node A33 = 2 intact nodes A34 = 4 intact nodes A35 = 3 intact nodes A36 = 2 intact nodes A37 = 1 bisected node at high point. MICROSCOPIC DESCRIPTION: . TYPE OF SPECIMEN:Right modified radical mastectomy . LOCATiON OF THE TUMOR: Central (6 o'clock), extending into lower inner and outer quadrants.. Ifl. TYPE OF NEOpLASM: Carcinoma, invasive, ductal, with central scar and micropapillary features. Poorly Differentiated, Total score 8 (Tubule Score 3, Nuclear Grade Score 3, Mitotic Score 2) Ductal carcinoma in situ, nuclear grade 3, multifocal 30 % Intraductal papillary subtype Intraductal micropapillary subtype Intraductal solid subtype Intraductal comedo subtype Necrosis is present within the intraductal carcinoma Lobular neoplasia is not present Iv. GROSS/MICRO FINAL INVA$IVE TUMOR SIZE INTERPRETATION: 3.5 x 3.0 x 2.0 cm. (In addition, separate foci of invasive carcinoma are seen superior to and lateral to the main mass these have a similar histology; the largest such focus measures 1.5cm on the slide. v. VASCULAR SPACE INVASION: Present in lymphatics VII. CALCIFICATION: Present in malignant areas VIII. NIPpLE: Present, uninvolved by cancer Ix. SKIN: Present, uninvolved by cancer x. ADJACENT BREAST TISSUE: Cystic disease, proliferative with atypia XI. MARGINS: Negative XII. AXILLARy LyMPH NODES: XII. AXILLARY LYMPH NODES: Page 2 of 3
+
+--- Page 3 ---
+TOTAL: 23 HIGH POINT:  1 XIII. POSITIVE LYMPH NODES XIII. POsITive LyMPh NODES: TOTAL: LEVEL i: 1 (adjacent to breast) EXTRANODAL EXTENSION: Present Xiv. PECTORAL MU$CLE: No pectoral muscle identified xv. PATHOLOGIC STAGING (pTNM) AJCC 7th Edition: Reflects staging only of the current specimen. UItlmate Staging responsibllity rests with the primary physician.. pT2: Tumor more than 2.0 cm but not more than 5.0 cm in greatest dirnension. pN1a: Metastasis in 1 to 3 axillary lymph nodes (at least 1 tumor deposit greater than 2.0 mm). This report has been reviewed electronically and signed on by Interpreted by: Attending The dlagnosis was rendered by the attending pathologist.. 'Note: Immunochemistry tosting perforned at wes developad and its performance characteristics determined by thee These tests were interpreted in conjunctlon with external positive and intenal negative cantrols, unless otherwise notod. It has not been cleared or approved by the US FDA. Thls test Is used for clinical purposes only. it should not be regarded as investlgatlonal or far research. END OF REPORT Page 3 of 3
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diff --git a/output/text/2d53e4f5-b924-4aad-9769-8a8620073ea6.txt b/output/text/2d53e4f5-b924-4aad-9769-8a8620073ea6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0b5144c311566772d658dbb225a88a8c3932d9b6
--- /dev/null
+++ b/output/text/2d53e4f5-b924-4aad-9769-8a8620073ea6.txt
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+
+--- Page 1 ---
+Sex. D.O.B.. MRN #: Ref Phyuran UUID:0F890724-8554-4B23-B4EC-689824C757D8 TCGA-AC-A3Y3-01A-PR Redacted SPECIMEI Collected: Received: Reported: SUrGICAL PATHOLOgY REPOR DIAGNOSIS DIAGNOSIS: A. Right sentinel tymph nodes, one lymph node: No evidence of metastatic carcinoma. Confirms frozen section diagnosis and confirmed by negative staining for pancytokeratin 1cDo3 B. Right breast mastectomy. Multiple areas of invasive papillary carcinoma. carc inoma,pa pi llun, No s Largest area size 3 cm. yoso/3 Architectural score: 1 of 3. SiK: breast,N0s C5.9 G-U~1Z R0 Nuclear score: 2 of 3. Mitotic score: 1 of 3. Total score: 4 of 9 - grade 1. Additional areas of in situ and invasive papillary carcinoma located in other quadrants of the breast. Criteria The largest area of confluent carcinoma measures 0.8 cm. Jiagnosis Discrepancy rimary Tumor Site Discrepan Na evidence of skin of nipple involvement. Overtying skin contains a large seborrheic keratosis. HIPAA Discrepancy ignancy Histon Deep margin of excision is free of carcinoma. QUALI IED TNM: T2pNO(i-)MX. Electronic Signature: CLINICAL INFORMATION CLINICAL HISTORY: Preoperative Diagnosis: Right modified radical mastectomy with sentinel node mapping with frozen section. Adenocarcinoma, with papillary subtype. (Papillary carcinoma) ER positive, PR positive. Postoperative Diagnosis: Symptoms/Radiotogic Findings: SPECIMENS: A. Sentinei node right, count 4600 with frozen section 8. Right breast tissue 1453 grams SPECIMENDATA Gross DescripTIon: The specimen is received in two containers labeled with the patient's name ' A. Container A is received fresh for frozen section, additionally labeled 'right sentinel node' and contains a 2.5 x 2.0 x 1.0 cm aggregate ot yeilow tan fibrofatty soft tissue. On palpation, a 1.3 cm firm fatty nodule is identified consistent with possible lymph node. The nodule is bisected and entirely submitted for frozen section. The residual is entirely resubmitted for permanent section in cassette A iabeled B. Container B is received with formalin additionally labeled 'right breast tissue' and consists of a 1439.4 gram, 27.5 x 19.0 x 6.5 cm simple mastectomy  specimen partially surfaced by pink-tan wrinkled skin which bears a central 1.5 x 1.0 x 0.2 cm slightty raised nippie. Orientation is not offered or possible.  Located 0.7 cm from the skin edge and 7.8 cm from the nipple is a 1.3 x 0.8 x 0.5 cm gray-brown raised skin lesion. Additional skin lesions are not  identined. The deep margin is inked and the specimen is serially sectioned to reveal a 2.8 x 1.5 x 1.0 cm cystic lesion containing pink-tan friable soft tissue, along with a radiographic dip. This lesion resides 4.5 cm from the skin surface and 2.2 cm from the inked deep margin. Multiple additional pink- tan rubbory lesions are idantifed diffusely scattered throughout the specimen and involve allfour quadrants. The largest of these remaining lesions is 3.0 x 1.8 x 1.8 cm and approaches to within 0.4 cm of the inked deep margin. The uninvoived areas are comprised of yellow-tan adipose tissue admixed wth moderate amounts of intersparsed gray-white fibrous tissue. Discrete axillary tail is not present, however, five firn fatty possible iymph nodes are  identified aiong one edge of the specinen. These possible lymph nodes range from 1.0 up to 1.4 cm in greatest dimension. Also received in the same container are two portions ot pink-tan wrinkled skin with yellow-tan subcutaneous fibroadipose tissue. These tissues are 8.0 x 2.0  1.3 cm and 16.0 x 3.0 x 2.0 cm. The cut surfaces are yellow tan fibrofatty with no discrete lesions. Representative sections are submitted in cassettes B1 through 13 labeled  esignated as follows: 1, nipple; 2, skin lesion, entirely; 3 and 4, radiographically located lesion; 5 and 6, Iargest additional lesion to inked uuup margin, perpendicular; 7 through 10, additional representative lesions from all four quadrants; 11, two whole possible lymph nodes; 12, two whole possible bisected lymph nodes (one inked): 13. one whole possible bisected iymph node. Additionally, a yeilow, areen and blue cassette are submitted for genomics research each labeled InirA-OPERATIVE CONSULTATiON: FROZEN SECTION DIAGNOSIS: Part A: No neoplasm identified (0/1) p.r D;
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diff --git a/output/text/2d61efd6-4f22-49ff-9f13-4e5fec609cb5.txt b/output/text/2d61efd6-4f22-49ff-9f13-4e5fec609cb5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b972f73b36fbcb2470de72defce57303a02c6672
--- /dev/null
+++ b/output/text/2d61efd6-4f22-49ff-9f13-4e5fec609cb5.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Patient Name Accession #: Med. Rec. #: Date of Procedure. DOB: Date ot Receipt: Gender: Date of Report: Ref. Physician: Account #: Patlent Address: Billing Type Auditional Copy to: Rel. Source: Clinical Diagnosis & History:.  Bilateral renal mass, right cystic mass teft solid mass consistent with neoplasm Specimens Submitted: 1: Kidney. loft: partiat nephrectomy. DIAGNOSIS: 1. Kidney, left; partial nephrectomy: Tumor Type: Renal cell carcinoma - Papillary type Type Il with eosinophilic cytoplasm and focally high grade nuclei Tumor Sizo Greatest dianeter is 3.8 cm.. Local Invasion (for renal cortical types) Not Identified Renal Vein Invasion: Not identified Surgical Margins Free of tumor Non-Neoplastic Kidney. Glomerular and vascular changes morphologically compatible with (PAS stain examined) Adrenal Gland: Not identifiod Lymph Nodes: Not identified Staging for renal cell carcinoma/oncocylona:  pT1 Tumor <= 7.0 cm in greatest dimension limited lo the kidney IATTEST THAT THE ABOVE OIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDESIANDIOR OTHER MATERIAL).ANO THAT I HAVE REVIEWED AND APPROVED THIS REPORT Page 1 of 2
+
+--- Page 2 ---
+Special Studies: Result  Special Stain. Commentd PAS Gross Description:. 1).The specimen is received fresh for Irozen section consultation and is tabeled "telt renal mass, freeze margin". li consists ol a 5.0 x 4.9 x 3.1 cn wedge shaped portion of kidney with a suture marking the deep margin. The margin is inked btack and the. specimen is serially seclioned to roveal a yellow brown granutar tumor measunng 3.8 x 3.0 x 2 7em. with an adjacent thin rim of red-brown renal parenchyma. The clearance from the resection margin is 0.3 cm. A representative section of the nearest margin  is submitted for Irozen section diagnosis. Additional reprosontative sections are submitted for TPS and routino processing. Summary ol sections:. Fsc . frozen seclion control TM - tumor to margin. T-tumor Rs - representative sections Summary of Sections:. Part 1:Kidney, left; partial nephrectony. Block Sect. Site. PCs 1 FSC 1 RS 1 1 1 r 1 2 TM 2 Intraopcrative Consultation: Nole: The diagnoses given in this section pertain only to the tissue sampte examined al the time of the intraoperative consultation Frozen section diagnosis: Left renal mass (is): Renal corlicat neoplasn, margin benign. Permanent diagnosis: Same  Page 2 of 2 END OF REPORT
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diff --git a/output/text/2d93c672-d43b-4ab6-b02b-f78e499cad7e.txt b/output/text/2d93c672-d43b-4ab6-b02b-f78e499cad7e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d91636cfa7f90e7208273916a5c61358769939a6
--- /dev/null
+++ b/output/text/2d93c672-d43b-4ab6-b02b-f78e499cad7e.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:3FA5FACA-8A6B-4F42-A557-3B69866859E7 CGA-LL-A7SZ-01A-PR Redacted RUN DATE: PAGE 1 RUN TIME: RUN USER: PATIENT: ACCT # LOC: AGE/SX: ROOM : * REG DR: DOB: BED: STATUS : SPEC #: RECD : STATUS : COLL : TIME IN FORMALIN: hrs. COLD ISCHEMA TIME: mins. CLINICAL INFORMATION:S Pre-Op Diagnosis: Remarks: Specimen(s): Left breast, stitch left axillary apex ID-O MICROSCOPIC DIANSI 85s0|3 LEFT BREAST. SKIN-SPARING RADICAL MASTECTOMY: INVASIVE DUCTAL CARCINOMA. HIGH GRADE NOTTINGHAM HISTOLOGIC SCORE  GLANDULAR/TUBULAR DIFFERENTIATION SCORE 3 Breast, usppy seate gusdrgnt NUCLEAR PLEOMORPHISM SCORE 3 Se$0.4 MITOTIC RATE SCORE 2 OVERALL GRADE 3 (8 OF 9) 9sJ/0/3 MARGINS UNINVOLVED BY INVASIVE CARCINOMA CARCINOMA IS 5.5 MM FROM THE CLOSEST MARGIN (POSTERIOR MARGIN)S MINUTE FOCUS OF HIGH-GRADE DCIS PRESENT WITHIN AREA OP CARCINOMA (1 MM IN SIZE) LYMPH-VASCULAR INVASION IDENTIFIED METASTATIC CARCINOMA INVOLVING TWO (2) OF ELEVEN (11) LYMPH NODES (2/11)) LARGEST TUMOR DEPOSIT IS 14.5 MMS EXTRACAPSULAR EXTENSION IDENTIFIEDS SEE SYNOPTIC REPORT COMMENT (S) SURGICAL PATHOLOGY CANCER CASE SUMMARY - APPROVED BYS PROCEDURE : Total mastectomy. skin sparing. LYMPH NODE SAMPLING: Axillary dissection SPECIMEN LATERALITY: Left TUMOR SITE: Upper outer quadrant.  HISTOLOGIC TYPE OF INVASIVE CARCINOMA : Invasive ductal carcinoma TUMOR SIZE: Greatest dimension of largest focus of invasion:. 25 mm Additional dimensions: 22 x 20 mm HISTOLOGIC GRADE (NOTTINGHAM HISTOLOGIC SCORE) : Glandular/tubular differentiation:.  score 3 Nuclear pleomorphism: score 3 ** CONTINUED ON NEXT PAGE **
+
+--- Page 2 ---
+RUN DATE: PAGE 2 RUN TIME RUN USER: SPEC #: PATIENT : (Continued) comment(s) (Continued) Mitotic rate: score 2 Ovorall grade: grade 3 TUMOR FOCALITY: Single focus of invasive carcinoma DUCTAL CARCINOMA IN SITU: DCIS is present Estimated size of ncIS: Architectural pattern: comedo Nuclear grade: grade III Necrosis: present. central LOBULAR CARCINOMA IN SITU: Not identified MARGINS : Invasive carcinoma: Margins uninvolved by invasive carcinoma Distance from closest margin: 5.5 mm.. posterior DCIS: Margins uninvolved by DCIS LYMPH NODES: Number of sentinel lymph nodes examined: 0 Total number of lymph nodes examined: 11 Number of lymph nodes with macrometastases: Number of lymph nodes with ITc: 0 Size of largest metastatic deposit:. 14.5 mm Extranodal extension: present Method of evaluation of sentinel lymph nodes: H&E. multiple levels LYMPH-VASCULAR INVASION: Present DERMAL LYMPH-VASCULAR INVASION: Not identified PATHOLOGIC STAGING: Primary tumor:  pT2 Regional lymph nodes:  pN1a Distant metastasis: not applicable. ANCILLARY STUDIES: (RESULTS FROM CASE Estrogen Receptor: positive (99% of tumor cells with nuclear positivity) Progesterone Receptor: positive (99% of tumor cells with nuclear positivity Her2/neu : Immunoperoxidase studies: negative (1+) GROSS DESCRIPTION: Received fresh is a skin-sparing left radical mastectomy weighing 756 grams and measuring 27 cm from medial to the axillary tail. 18 cm from superior to inferior. and 2.5 cm anterior to posterior. There is a linear portion of skin including nipple measuring 9 x 2.1 cm. A mass is palpated in the lower portion of the upper outer quadrant. The deep margin underlying this tumor is inked black. and the anterior margin is inked blue. A cut is made from the posterior side. and a portion of tumor is given to the Tumor Bank. The 1 tumor measures 2.5 x 2.2 x 2.0 cm. It is firm with focal areas of hemorrhage.  There is an. adjacent well-circumscribed tan-white soft. freely mobile area measuring up to 4.5 cm in greatest dimension. The carcinoma measures 0.8 cm from the posterior black-inked margin and 0.9 cm from the anterior blue-inked margin. The other margins are greater than 3 cm ** CONTINUED ON NEXT PAGE **
+
+--- Page 3 ---
+RUN DATE PAGE 3 RUN TIME: RUN USER: SPEC #: (Continued) GROSS DESCRIPTION:(Continued) from the tumor including the nipple.  The remainder of the breast is serially sectioned to. reveal no additional masses, cysts or other gross abnormalities. There is a fat to fibrous ratio of up to 50:50. The most fibrotic areas are closest to the lateral quadrants. particularly the upper outer quadrant. The detached axillary tail itself measures 13.2 x 5.5 x 2.6 cm. Serial section reveals multiple lymph nodes, the largest of which measures 2.2 x 1.5 x 1 cm. Sections are as follows: tumor as it most closely approximates the anterior margin. 2 tumor as it most closely approximates the posterior margin. 3 additional representative section of tumor 4 representative section of fibrotic area adjacent to tumor. 5 representative section of nipple 6-7 additional representative sections of very fibrotic areas in the. lateral guadrant 8 representative sections of the medial quadrants 9-10 multiple lymph nodes 11-12 one lymph node each. bisected Signed (signature on file) ** END OF REPORT ** ./23/l3
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diff --git a/output/text/2da8a4ce-f798-4766-9cf6-11a754e853e2.txt b/output/text/2da8a4ce-f798-4766-9cf6-11a754e853e2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..840d0dd7833388012275bd77c602aeeeef1a6d1e
--- /dev/null
+++ b/output/text/2da8a4ce-f798-4766-9cf6-11a754e853e2.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UUID:860A2391-F581-4E5B-AEDB-FD318817F1F1 Redacted TCGA-DK-A3IM-01A-PR SURGICAL PATHOLOGY REPORT i Patient Name: Accession #: Med. Rec. #: Date of Procedure: DOB: (Age: Location: Date of Receipt: Gender: M Service:  Urology Date of Report: Ref. Physician: Account #: Patient Address: Billing Type: INPATIENT Additional Copy to: Ref. Source: Clinical Diagnosis & History:.  year old male with bladder diverticulum with high grade tumor.. Specimens Submitted:. 1: Soft tissue bladder margin (fs).  2: Bladder diverticulum, urachus, perivesicle tissue, lymph nodes, upper portion of bladder, distal right ureter 3: Right vas deferens 4: Right pelvic lymph nodes 5: Perivesical fat 6: Piece of omentum 7: Periureteral tissue  8: Perivesical tissue DIAGNOSIS: 1. Soft tissue, bladder margin; excision (fs): - Benign fibroadipose tissue.e 2.  Bladder diverticulum, urachus, perivesicle tissue, lymph nodes, upper portion of bladder, distal right ureter: Tumor Type: Urothelial carcinoma with mixed histologic features,  including: urothelial carcinoma NOs, keratinizing  squamous and small cell/neuroendocrine involving a bladder diverticulum Histologic Grade:  High grade /co-0-3 Pattern of growth of the Non-Invasive component:. Papillary and flat go7if3 Sinsil till, newrmdotrm Pattern of growth of the Invasive component:. 8041|3  Infiltrating Cod+ hughuat) Tumor Multicentricity: Identified Sih. b/oddw, Nos Cl7.9 Bladder Local Invasion: 112/1  Perivesical soft tissues Extravesical Tumor Extension:e Right ureter uninvolved Left ureter uninvolved Urethra uninvolved Vascular Invasion: Identified  Perineural Invasion: 1 2/Q9.J n Page 1 of 5
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT Identified Surgical Margins: Free of tumor Non-Neoplastic Mucosa: Exhibiting chronic cystitis Exhibiting denudation Prostate: Not identified Seminal Vesicles: Not identified Perivesical Lymph Nodes: Not identified The Pathologic Stage is (AJCC 2002): pT3 (Invasion of perivesicle soft tissue) 3.Vas deferens, right; resection: - Benign vas deferens. Right pelvic lymph nodes: 4 Lymph Node Dissection: Benign lymph nodes Number of lymph nodes examined: 8 Soft tissue , perivesical fat; excision: - Benign fibroadipose tissue. 6. Omentum; resection: - Benign adipose tissue. Soft tissue, periureteral tissue; excision: - Benign fibrovascular and adipose tissue. 8. Soft tissue, perivesical tissue; excision: - Benign fibroadipose tissue. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND.APPROVED THIS REPORT. *** Report Electronically Signed Out *** Special Studies: Result Special Stain Comment SYN CHR AE1:AE3 TTF-1 Page 2 of 5
+
+--- Page 3 ---
+SURGICAL PATHOLOGY REPORT RECUT IMM RECUT NEG CONT Gross Description:  The specimen is received fresh for frozen section consultation, labeled, "Soft tissue bladder margin (fs)" and consists of a fragment of soft pink and yellow tissue (1.5x 0.6x 0.3 cm). The specimen is entirely frozen and submitted in one cassette. Summary of sections: FSC - frozen section control. 2). The specimen is received fresh labeled "Urachus, perivesicular tissue lymph nodes, upper portion of bladder, bladder diverticulum, distal right ureter" and consists of a portion of bladder, diverticulum, portion of ureter, and perivesicular tissue. The portion of bladder is received opened with a dusky purple-pink but otherwise unremarkable mucosa measuring 8.6 x 7.5 cm with underlying perivesicular tissue measuring 11.0 x 9.5 x 1.5 cm. The attached closed pouch like diverticulum measures 7.2 x 6.0 x 3.0 cm and is attached by a 1.8 x 0.5cm piece of the opened bladder mucosa.. The anterior wall of the diverticulum displays a 1.8 x 1.5 cm transmural defect of a possible urachus, the tissue surrounding the defect is inked orange, the remaining anterior aspect is inked black.. The posterior surface of both the diverticulum and bladder perivesicular tissue are inked blue.. The right aspect of the diverticulum has an adhered segment of ureter measuring 3.0 cm in length by 0.5 cm in diameter. The ureter has one clip and an opposing opened end. The diverticulum is opened to reveal a yellow-brown fungating papillary friable tumor measuring 4.7 x 4.3 x 1.5 cm, 4.1 cm from the transmural defect and 1.0 cm from the attached bladder mucosa..  There is a second adjacent raised papillary nodule measuring 2.5 x 2.2 x 0.9 cm, 0.2 cm from the fungating tumor, 2.0 cm from the transmural defects, and 5.6 cm from the attached bladder mucosa. Upon sectioning the two tumor nodules join and there is papillary extension to a depth of 1.8cm. The remaining bladder diverticulum mucosa is yellow and smooth..  The tumor is 1.0 cm from the attached ureter and the ureter is grossly uninvolved with the tumor. Both of the ureter margins are shaved and submitted en face. Perpendicular sections of the bladder mucosa margins are submitted ner clock face with 12 o'clock arbitrarily designated in pathology by the diverticulum attachment site.. Gross photos are taken. is taken. Representative sections are submitted. Summary of sections: BM3 - bladder margin 3 o'clock BM6- lateral margin 6 o'clock (opposite the diverticulum attachment site) BM9 - bladder margin 9 o'clock TB - diverticulum tumor to attached portion of bladder TN - diverticulum tumor to smaller nodule ND - smaller nodule to transmural defect TU - tumor to ureter. UC - ureter margin (clipped end) UO - ureter margin (opened end) DIV - additional representative sections of diverticulum BL - additional representative sections of bladder F - tumor to greatest depth of invasion 3.The specimen is received in formalin, labeled "right vas deferens," and consists of a segment of vas deferens that measures 3.1x 0.6 x 0.4 cm. The specimen is serially sectioned and entirely submitted. Summary of sections: U - undesignated  Page 3 of 5
+
+--- Page 4 ---
+SURGICAL PATHOLOGY REPORT 4.The specimen is received in formalin, labeled "right pelvic lymph nodes," and consists of multiple lymph nodes that measure up to 2.2 cm in greatest dimension.The specimen is entirely submitted. Summary of sections:. BLN - bisected lymph node LN - lymph nodes 5.The specimen is received in formalin, labeled "perivesical fat," and consists of a piece of fibrofatty tissue that measures 5.8 x 4.2 x 1.5 cm. The specimen is serially sectioned to reveal yellow, homogeneous cut surfaces. Representative sections are submitted. Summary of sections: U -- undesignated 6.The specimen is received in formalin, labeled "piece of omentum," and consists of a piece of fibrofatty tissue that measures 7.9 x 3.2 x 2.8 cm. The specimen is serially sectioned to reveal yellow, homogenous cut surfaces. Representative sections are submitted. Summary of sections: U -- undesignated 7.The specimen is received in formalin, labeled "perivesical tissue" and consists of a piece of fibrofatty tissue that measures 2.3 x 1.8X 0.4 cm.The specimen is entirely submitted. Summary of sections: U -- undesignated 8.The specimen is received in formalin, labeled "periureteral tissue" and consists of a piece of fibrofatty tissue that measures 0.5 x 0.4 x  0.4 cm.The specimen is entirely submitted. Summary of sections: U -- undesignated. Summary of Sections:. Part 1:  Soft tissue bladder margin (fs) BJock Sect. Site pCs 1 FSC Part 2:  Bladder diverticulum, urachus, perivesicle tissue, lymph nodes, upper portion of bladder, distal right ureter Block Sect. Site PCs 2 BL 2 1 BM3 1 1 BM6 1 1 BM9 1 2 DIV 2 2 F 2 1 ND 1 1 T 1 4 TB 4 3 TN 3 2 TU 2 1 UC 1 1 UO 1  Page 4 of 5
+
+--- Page 5 ---
+SURGICAL PATHOLOgY REPORT Part 3: Right vas deferens Block Sect. Site PCs U 2 Part 4:  Right pelvic lymph nodes Block Sect. Site PCs 2 BLN 3 2 LN 3 Part 5:  Perivesical fat Block Sect. Site PCs 1 U 2 Part 6: Piece of omentum. Block Sect. Site PCs 1 U 2 Part 7: Periureteral tissue Block Sect. Site PCs U 2  Part 8: Perivesical tissue Block Sect. Site PCs 1 U 2 Intraoperative Consultation: Note:  The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 1. Frozen section diagnosis: Soft tissue bladder margin (fs): :Benign fibroadipose tissue( Permanent diagnosis: SAME Page 5 of 5 END OF REPORT
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diff --git a/output/text/2dc19d08-c870-4216-a281-f0f1ecf419ba.txt b/output/text/2dc19d08-c870-4216-a281-f0f1ecf419ba.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8644edfeaa53e17ae926bf639c61a4ca75714551
--- /dev/null
+++ b/output/text/2dc19d08-c870-4216-a281-f0f1ecf419ba.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+*** Diagnosis / Diagnoses: *** Resected cross-section of the colon with tumor-free resection margins, under inclusion of a tubular adenoma with mild dysplasia (synonym: low-grade intra-epithelial neoplasia) and a tubulovillous adenoma with focal severe dysplasia (synonym: high-grade intra- epithelial neoplasia) and with a well to moderately differentiated colorectal adenocarcinoma (G1 to 2) with infiltration of the lamina muscularis propria and without regional lymph node metastases (pT2 pN0 0/31) on the base of a further tubulovillous adenoma with severe dysplasia. Final preliminary results
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diff --git a/output/text/2debd524-f9c0-4fd4-99d5-a7f40f502a15.txt b/output/text/2debd524-f9c0-4fd4-99d5-a7f40f502a15.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3fe960f33855e8b453eedecbec69bafd44daf99b
--- /dev/null
+++ b/output/text/2debd524-f9c0-4fd4-99d5-a7f40f502a15.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+tcD-o 3 eneesuxore HQS 8i40/3 0j8.4 ) 4/12/13 Final Surgical Pathology Report Procedure: Diagnosis Colon, ileocolectomy: Moderately differentiated adenocarcinoma of the transverse colon. invasive through muscular wall into attached greater omentum (pT3)  Metastatic adenocarcinoma in 1 of 60 lymph nodes (pN1) Extranodal tumor present UUID: 3E30630A-1BAB-480C-9C75-13E8289072660 Serosal adhesions TCGA-A6-A5ZU-01A-PR Redacted Appendix with serosal adhesions. Resection margins negative. Microscopic Description: Microscopic examination performed. Histologic type: Adenocarcinoma, not otherwise specified Histologic grade: Moderately differentiated Primary tumor (pT): Invasive through muscularis propria of transverse. colon into attached greater omentum (pT3) Proximal margin: Negative Distal margins: Negative Circumferential (radial) margin: Negative Distance of tumor from closes margin: 8 cm from distal margin. Vascular invasion: Not identified. Regional lymph nodes (pN): One 60 lymph nodes is positive for. metastatic tumor (pN1) Non-lymph node pericolonic tumor: Present Distant metastasis (pM): Not applicable (pMX) Other findings: Serosal adhesions. Clinical obstruction. Appendix with serosal adhesions.  No specific additional pathologic abnormalities identified the colon or the ileum. MSI testing: Ordered on block A2 Pathologic stage T3Nl IIIB Specimen Right hemicolectomy Clinical Information Transverse colon cancer with clinical obstruction
+
+--- Page 2 ---
+Gross Description Received fresh labeled "right hemicolectomy" is a previously unopened 40 cm segment of proximal right colon with attached 15 cm of distal ileum and an abundant amount of attached mesocolon, mesentery, and omentum. An unremarkable 9 cm appendix averaging 0.5 cm in diameter is present.  The proximal and distal margins measure 5.2 and 7.8 cm in circumference respectively.. On opening, there is a circumferential,. 6.0 x 3.9 cm rubbery tan-white-red tumor mass which is 8 cm from the distal margin.. On sectioning,.  the tumor has a maximal thickness of 2. cm, grossly extending through the muscularis and into the attached mesocolon.  The tumor is present within 0.2 cm of the inked free radial serosal surface and visually appears to extend into the attached omentum. A 3 cm in greatest dimension area of tan red discoloration is noted within the distal ileum, 5 cm proximal to the ileocecal valve.. The remaining ileal and colonic mucosa is unremarkable tan-pink with regular folds and the walls average 0.5 cm..  A portion of tumor and a as requested.  Multiple soft to slightly rubbery tan-pink tissues in keeping with lymph nodes measuring up to 1.3 cm are recovered from the attached mesocolon and mesentery.. RS 21 Summary: 1 - margins, 2 through 4 - tumor to inked free radial serosal surface (cassettes 3 and 4 including attached omentum), 5 and 6 - central tumor, 7 - discolored area of ileum, 8 - Icv, 9 and 10 the nodes per cassette,  19 - 6 lymph nodes, 20 and 21 - 1 bisected lymph node per cassette. lw 3/s|3
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diff --git a/output/text/2df5bcec-b6d7-4a8c-b83d-15453698b0cb.txt b/output/text/2df5bcec-b6d7-4a8c-b83d-15453698b0cb.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7bc9cb5d5dcc27dfc379f72ae7ee264634fb54b0
--- /dev/null
+++ b/output/text/2df5bcec-b6d7-4a8c-b83d-15453698b0cb.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+Clinical Diagnosis & History:. Y/o male with left breast cancer (invasive ductal carcinoma (Idc)). Specimens Submitted: 1: SP: Sentinel node #1, level 1, left axilla (fs) : UUID:E85199BA-6164-4CFB-AFAA-B41544883103 TCGA-AO-A1KQ-01A-PR 2: Sp: Left breast with levels one and two axillary contents Redacted DIAGNOSIS: 1) LYMPH NODE, LEFT AXILLA, SENTINEL LYMPH NODE #I; LEVEL 1; BIOPSY: - METASTATIC CARCINOMA IN ONE LYMPH NODS (1/1). . THE METASTATIC DEPOSIT IS SEEN ONLY ON THE ACTUAL FROZEN SECTION AND MEASURES AT LEAST 2 mm.  NO EXTRANODAL EXTENSION IDENTIFIED. - THE LYMPH NODE EXHIBITS INCIDENTAL BENIGN CAPSULAR NEVOS CELL AGGREGATES . 2) BREAST. : LEET: MASTECTOMY: INVASIVE DUCTAL CARCINOMA. NOS TXRE. HISTOLOGIC GRADE IHI/III (SLIGHT OR NO TUBOLE FORMATION), NOCLEAR GRADE III/III (MARKKD VARIATION IN SIZE AND SHAPE), MEASURING 2.2 CM IN LARGEST DIMENSION MICROSCOPICALLY. - DUCTAL CARCINOMA IN-SITU (DCIS) IS ALSO IDENTIFIED, SOLID, CRIBRIFORM TYPE WITH HIGH NUCLEAR GRADE AND MODERATE NECROSIS. - THE DCIS CONSTITUTES <- 25t OF THE TOTAL TUMOR MASS, AND IS PRESENT ADMIXED WITH AND AWAY FROM THE INVASIVE COMPONENT. - THE INVASIVE CARCINOMA IS LOCATED IN THE LOWER INNER QUADRANT AND CENTRAL AREA (RETROAREOLAR). - THE NIPPLE IS INVOLVED BY INVASIVE CARCINOMA.  A FOCUS OF PERINEURAL INVASION BY CARCINOMA IS SEEN IN THE DERMIS OF THE NIPPLE REGION. THERE IS ALSO FOCAL LYMPHATIC INVASION IN THE NIPPLE /Cs-0-3 REGION.  CALCIFICATIONS ARE PRESENT IN THE IN SITO CARCINOMA. Cavcinoma nifiPtratng ouctal, N0s 85o0f3 - NO INVOLVEMENT OF THE SORGICAL MARGINS BY EITHER INVASIVE OR IN SITU CARCINOMA IS IDENTIFIED.S Site busot, N0s c50.9 - THE NON-NEOPLASTIC BREAST TISSUE IS UNRENARKAELE. THE LYMPH NODE STATUS IS AS FOLLOWS (EXPRESSED AS THE NUNBER OF POSITIVE LYMPH NODES IN RELATION TO THE TOTAL NUMBER OF LYMPH NODES EXAMINED) : - METASTATIC CARCINONA IN ONE OF BIGHT LYMPH NODES (1/8). - THIS IS A MACROMETASTASIS (1.8 CM). THERE IS NO EXTRANODAL EXTENSION OF CARCINOMA. Continued on next page *.
+
+--- Page 2 ---
+- Page 2 of 4 STAINS ER HER2-NEU) WILL BE REPORTED AS AN AddenDUM. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. * Reput  Electronically Signed Out Special studies: Result Spocial stain Comment ER-C pR-C HER2-C NEG CONT NEG-HER2 IMM RECUT Grogs Description: 1).The specimen is received fresh for frozen section consultation labeled. *Sentinel node #1, level 1. left axilla". and consists of  One lynph node measuring 1.5 x 1.0 x 0.8 cm. The lymph node is bisected and submitted fox frozen section diagnosis. Summary sections: Fsc - 1 frozen section control 2). The specimen is received fresh labeled, "Left breast with levels one and two axillary contents, stitch marks axillary tail" and consists of a breast measuring 19 x 18 x 3.5 cm with overlying skin cllipse measuring 19 x 11 cm, attached axillaxy contents measuring i1 x 10 x 3 cm.  The axillary tail is marked with a black suture. Situated cantrally on the skin surface is a flattanad nipple maasuring 0.8 x 0.8 cm and araola measuring 2.5 x 2.5 cm.. There are no scars or lesions noted on the skin.  suture demarcates the axillary aspect. The posterior surface of the breast is inked black and the specimen is serially sectioned to reveal a well circumscribed stony hard whita-tan tumor moasuring 3.0 x 2.0 x 1.7 cm, and located 1.8 cm from the the breast tissue is yellow tan fatty and lobulated. The remainder of The specimen is Submitted for lymph node dissection. Representative sections are submitted. A sample of the tumor is given to Sumnary of sections: N nipple *+ Continued on next page
+
+--- Page 3 ---
+NB  - nipple base DM -  deep margin T . tumor UIQ - upper inner  quadrant LIQ lower inner quadrant UOQ upper outer quadrant LOQ lower outer quadrant LN-Iymph nodes Summary of Sections:. Part 1:  SP: Sentinel node #1, level 1, loft axilla (fs). Block Sect. site pCs 1 FSC 1 Part 2: SP: Left breast with levels one and two axillary. contents Block Sact. Site PCs dm 1 1iq 1 LN 8 1 1oq 1 o. 1 nb 61 : 6 uiq H H 1 uoq Procedures/Addenda:d Addendum Date Ordered: Status: Signed Out. Date Complete: By: Date Reported: Addendum Diagnosisd ADDEN SITE: #2. LEFT BREAST ER: >95t Or NUCLEAR STAINING WITH STRONG INTIXSITY. .PR: >80% OF NUCLEAR STAINING WITH STRONG TO NODERATE INTENSITY. -HER-2/NEU (Hexcep Test) : NEGATIVE (STAINING INTENSITY OF FOCAL 1+) . CONTROLS ARE SATISPACTORY. Continued on next page
+
+--- Page 4 ---
+Intraoperative Consultation: examined at the time of the intraoperative consultation. sample 1) FROZEN SECTION DIAGNOSIS: METASTATIC CARCINOMA PERMANENT DIAGNOSIS: SAME. End of Roport *
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diff --git a/output/text/2dfd8e58-d585-4136-9db0-060e972798cf.txt b/output/text/2dfd8e58-d585-4136-9db0-060e972798cf.txt
new file mode 100644
index 0000000000000000000000000000000000000000..659574dcc19fc6d6de69ce569de0d9fa6ebb7043
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+1cD-0: 3 Procedure Date: Catinmo, midullerg, nos 951013 Procedure Physician: Site. Brust, NUs C 50.9 1/21/n Attending Physician/Copies To: Nw UUID:7B1B31D2-0CC5-4EE6-8AF3-16DF726BE13F TCGA-BH-A1FC-01A-PR Redacted PATIeNT hISTORY: * DATE OF LMP: * DATE OF LAST DELIVERY: PRE-OP DIAGNOSIS: R BREAST CANCER POST-OP DIAGNOSIS: SAME OPERATIVE PROCEDURE: R SEGM MASTECTOMY; R AXILLARY DISSECTION CLINICAL BISTORY: MATERIAL SUZNITTED: A) RIGHT) BREAST BIOPSY/MASS/SEGMENTAL MASTECTOMY, PROCUREMENT BY SURGICAL PROCEDURE B) RIGHT AXILLA, PROCUREMENT BY SURGICAL PROCEDURES INTRAOPERATIVE CONSULTATION: cOnsult: Right breast tissue; 9.5 by 8.5 by 1.5 cm. Tumor; 1.3 by 1.2 by 1.0 cm. Margins are grossly free of tumor. FINAL DIAGNOSIS: PREVIOUS REPORT: A) RIGHT BREAST (SEGMENTAL MASTECTOMY) : INFILTRATING MEDULLARY CARCINOMA (Ai,A2), I.3 BY 1.3 BI T:O CM, POOR HISTOLOGIC AND NUCLEAR GRADE (SEE) NOTE) - NARGINS OF RESECTION ARE FREE OF TUMOR  PROLIFERATIVE FISROCYSTIC CHANGES B) ONE OF TWENTY-THREE (1/23) RIGHT AXILLARY LYMPH NODES WITH METASTATIC CARCINOAA AND EXTRACAPSULARS EXTENSION'(SLE NOTE) NOTe: The tumor is high grade with syncytial pattern and extenaive lymphocytic reaction. No in situ carcinoma is present. One large lymph node is corpletely replaced by tumor with extracapsular extension (87). ER/pR immunoperoxidase assay and Her-2/Neu testing will be performed on block A2. SUPPLEMENTALREPORT (ER/PR'S My aignature below is attestation that I have reviowed all slides and agree with the findings as noted. below. IMMUNOPEROXIDASE IDENTIFICATION OF ESTROGEN AND PROCESTERONE RECKPTORS IS CARRIED OUT ON SLIDR "A2". NO DISTINCT INTRANUCLEAR STAINING IS IDENTIFIED FOR EITHER RECKPTOR. THEREFORE, BOTH ARE INTERPRETED AS NEGATIVE  Pathologist SUPP EMENTALREPORT (HER-2/NEU) as noted My signature balow is attestation that I have reviewed all slides and agree with the findinga. below. AS PER THE REQUEST OF D, O ,C-erbB2 (HER-2/NEU) IMMUNOSTAINING I8 CARRIEO OUT ON PREVIOUS MAGZE SURGICALS BLOCK "A2" (BREAST CANCER) USING A 1:3OO DILUTION OFS DAKO'S POLYCLONAL ANTIBODY A48S (DIRECTED AGAINST THE INTRACELLULAR DCNAIN OF C-erbB2) WITHOUT ANTIGEN RETRIEVAL. NO DISTINCT COMPLETE MEMBRANE STAININC IS IDENTIFIED. THERBFORE, C-OrbB2 (HER-2/NEU) I8 INTERPRETED AS NEGATIVE. Criter
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diff --git a/output/text/2e12ab81-fc47-4e4c-9c90-e8dc0b016fac.txt b/output/text/2e12ab81-fc47-4e4c-9c90-e8dc0b016fac.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8c631ff482bc2b7c3d4b3c649e2f8b84bea857ba
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+Carcinvma, mfiItratng dluctal, nos 85o0f3 Site: breast, NOs c50.9 1/25/u Su Surg Path CLINICAL HISTORY: Left breast mass. FNA positive for CA. GROSS EXAMINATION: A. "Left breast biopsy, short superior, long lateral", gross consult, received. fresh. Received is 83 grams of fatty tissue (7.5 x 7 x 3 cm) which contains a 1.5 x 1.5 x 1.3 cm firm white stellate mass. A short suture designates the superior and a long suture the lateral margin. The deep margin is inked blue, superior black, and inferior red. The firm mass is 0.8 cm from its closest margin (the superior-inferior border on the anterior surface) and 1 cm its next nearest margin, the deep margin.  Lateral to the mass and distinct from it is a region of extensive rubbery, white fibrous tissue. A portion of the mass is submitted for ER/pR. The entire tumor and its surrounding tissue, and representative sections of the fibrous region are submitted sequentially from medial to lateral in Blocks Al-Al4. with the tumor in Blocks A2-A8. Dr. with Dr. INTRA OPERATIVE CONSULTATION: A. "Left breast biopsy", (gross consult): 0.8 cm from closest resection. margin, at the superior-inferior border on the anterior surface. 1 cm from deep margin. DIAGNOSIS: "LEFT BREAST BIOPSY" (EXCISIONAL BIOPSY) : A. INFILTRATING DUCTAL CARCINOMA. N.S.A.B.P. HISTOLOGIC GRADE: 2 OF 3. N.S.A.B.P. NUCLEAR GRADE: 2 OF 3. GROSS TUMOR SIZE: 1.6 CM. IN-SITU CARCINOMA, PRESENT: OCCUPYING LESS THAN 1O% OF TUMOR VOLUME. TYPE OF IN SITU CARCINOMA: SOLID AND CRIBRIFORM. LYMPHATIC/VASCULAR INVASION: NOT UNEQUIVOCALLY PRESENT. SURGICAL MARGIN STATUS: NEGATIVE. STATUS OF UNINVOLVED BREAST TISSUE: MILD FIBROCYSTIC CHANGE. ESTROGEN/PROGESTERONE AND CELL CYCLE ANALYSIS PENDING: YES. METHODOLOGY: FRESH TISSUE. RESULTS WILL BE ISSUED IN AN ADDENDUM. Verified by: .M.D. Pager. Date Signed: ADDENDUM 1: Tissue was sent to the for assay of the estrogen and progesterone receptors. The estrogen receptor activity was judged as positive with an estimated FMoL value of 39. The progesterone receptor activity was judged as negative with an estimated FmoL value of 0. Please refer to for a complete report. Verified by: M.D. Pager# Date Signed: UUID: 36AE47A6-B881-4C1D-8436-EB65783243CF TCGA-B6-A0WS-01A-PR Redacted
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diff --git a/output/text/2e1c795c-1dad-42d4-9f52-827628eb6d4c.txt b/output/text/2e1c795c-1dad-42d4-9f52-827628eb6d4c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..968d04a62d6bd8c876d8c7df00cf13fcebc04091
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+
+--- Page 1 ---
+UUID:48F86416-8304-479E-B477-7C37A2F951A2 / cs - 0 - 3 CGA-AR-A0TZ-01A-PR Redacted S.t: bresot, Nus C50.9 Breast, left, modified radical mastectomy: Invasive ductal carcinoma, Nottingham grade II, is identified forming multiple (5) masses in the left breast. The largest mass is situated in the upper outer quadrant and measures 3.2 x 2.7 x 2.3 cm (AJCC pT2). Additional nodules are situated inferior and just superior to the main mass and range in size from 0.5 cm to 0.8 cm in diameter. There is approximately 10% component of ductal carcinoma in situ, cribriform type, intermediate nuclear grade. Skin, nipple, and deep margin are free of neoplasm. Multiple (6 of 30) left axillary lymph nodes are positive for metastatic carcinoma, including multiple (2) matted lymph nodes (AJCC pN2). HER2/neu has been ordered on paraffin embedded tissues.
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diff --git a/output/text/2e2d7f3d-8d50-4b3b-bfae-d6cc0ede2bfd.txt b/output/text/2e2d7f3d-8d50-4b3b-bfae-d6cc0ede2bfd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d97b48f1dfef30ec80c96f30a729072959e6cdee
--- /dev/null
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+
+--- Page 1 ---
+UUID:A786FCF6-1881-40B5-AD92-54681CBC8FE0 TCGA-A2-A3XZ-01A-PR Redacted Specimen: Received: Spec Type: SURGICAL P Statust Subm Dr: PREOPERATIVE DIAGNOSISS LEFT BREAST CANCER INVASIVE OPERATION PERFORMED DATE: DOctoR(s) : PROCEDURE: TISSUE REMOVED icd-o-3 A. LT SIMPLE MASTECTOMY B. LT AXILLA SENTINEL NODE #1 Carc/nona,inF1+ati rq duof,N0S C. LT UPPER INNER CORE BX D. LT BREAST SUPERFICIAL MARGIN  t S f3 E. LT AXILLA SENTINEL NODE #2 Si+: br<gst,Nos <ROSS DESCRIPTION C50.9 PART A RECEIVED FRESH LABELED 5-z3-rz ep STITCH 12 O'CLOCK, IS A LEFT SIMPLE MASTECTOMY SPECIMEN MEASURING 16 X 16 LEFT SIMPLE MASTECTOMY X 3.5 CM.  THE NIPPLE IS UNREMARKABLE WITHIN A 7.5 X 4.2 CM SKIN ELLIPSE. BLUE DYE IS NOTED IN THE SUPERIOR 12 O'CLOCK AREA OF THE BREAST. THE SUPERFICIAL ASPECT IS MARKED WITH BLUE INK, THE DEEP WITH BLACK. AN M CLIP IS IDENTIFIED IN THE UPPER INNER QUADRANT MEDIAL ASPECT, ASSOCIATED WITH A PINK-TAN NODULE AT THE SUPERFICIAL MARGIN MEASURING O.9 X O.5 X 1.2 CM. THIS IS 1.3 CM FROM THE DEEP MARGIN, 1 CM FROM THIS IS A 0.3 CM FIRM GRAY-TAN AREA WHICH IS 1 CM FROM THE SUPERFICIAL MARGIN AND 1.1 CM FROM THE DEEP MARGIN GROSSLY. ELONGATED IRREGULAR PINK-TAN FIRM AREA WHICH ALSO EXTENDS GROSSLY TO THE  IN THE 11 O'CLOCK AREA THERE IS AN SUPERFICIAL MARGIN. THIS MEASURES 3.5 X 0.9 AND IS 1.5 CM IN GREATEST DIMENSION. THIS LESION IS GROSSLY 3 CM FROM THE FIRST DESCRIBED LESION. THIS LESION GROSSLY EXTENDS TOWARDS THE SUPERFICIAL MARGIN AND IS 1.2 CM FROM THE DEEP MARGIN. THE BREAST TISSUE ITSELF HAS AN OVERALL INDURATED QUALITY TO PALPATION WITH A DIFFUSE YELLOW-GRAY APPEARANCE. THE INFERIOR AND LATERAL ASPECTS DEMONSTRATE A MORE FATTY APPEARANCE. ALSO IN THE AREA OF THE UPPER INNER QUADRANT, THE PARENCHYMA HAS MULTIPLE SMALL PALPABLE LESIONS. THIS IS IN THE AREA OF THE BLUE DYE. IT IS SECTIONED TO DEMONSTRATE THIS WHICH IS SLIGHTLY INFERIOR AND TOWARD THE NIPPLE FROMS THE SECOND DESCRIBED LESION SUBMITTED IN A1O (MIRROR IMAGE TO PROTOCOL). RANDOM TISSUE IS ALSO TAKEN FROM THE 9 O'CLOCK AREA WHICH HAS THISS DIFFUSE INDURATED QUALITY. Al--NIPPLE AND SKIN (MIRROR IMAGE TO PROTOCOL), A2~-1O O'CLOCK PERIPHERAL) THE SECTIONS ARE SUBMITTED AS FOLLOWS: LESION TO INCLUDE SUPERFICIAL AND DEEP MARGINS (MIRROR IMAGE TO PROTOCOL), A3--1O O'CLOCK LESION (MIRROR IMAGE TO PROTOCOL), A4--SMALL O.3 CM NODULE WITHIN TISSUE (MIRROR IMAGE TO PROTOCOL). A5--SECTION OF 11 O'CLOCK LESION (MIRROR IMAGE TO PROTOCOL). A6 THROUGH A8--FOR CROSS-SECTION OF 11 O'CLOCK LESION TO INCLUDE THE MOST SUPERIOR AND SUPERFICIAL, DEEP AND SUPERFICIAL INFERIOR ASPECT OF LESIONS TO INCLUDE SUPERFICIAL MARGIN RESPECTIVELY, A9--11 O'CLOCK LESION (MIRROR IMAGE TO
+
+--- Page 2 ---
+Specimen: Received: Status: Speg Type: SURGICAL P 8ubm Dr: CROSS DESCRIPTION (Continued) PROTOCOL), A1O--TISSUE UPPER OUTER QUADRANT, A11--TISSUE 9 O'CLOCK A REGION, A12--UPPER OUTER QUADRANT 4 CM FROM THE 11 O'CLOCK LESION (MIRROR IMAGE TO PROTOCOL), A13--LOWER OUTER QUADRANT 8 CM FROM THE LESION (MIRROR IMAGE TO PROTOCOL), A14--LOWER INNER QUADRANT.S PART B RECEIVED FRESH LABELED  LEFT AXILLA FIRST SENTINEL NODE HOT AND BLUE, IS A AN OVOID PORTION OF PINK-TAN SOFT TISSUE MEASURING 2.5 X 1.3 X 1.0 CM. SECTIONING REVEALS A 1.8 CM GROSSLY UNREMARKABLE LYMPH NODE WITHOUT OBVIOUS BLUE COLORATION.  ONE HALF IS SUBMITTED LABELED B. THE REMAINDER IS SUBMITTED PER PROTOCOL. PART C RECEIVED LABELED LEFT UPPER INNER CORE BIOPSY SITE, IS AN UNORIENTED ELLIPTICAL PORTION OF BROWN SKIN AND UNDERLYING INDURATED FATTY TISSUE.  THE SKIN ELLIPSE IS 1.4 X Q.5 CM. THE UNDERLYING TISSUE MEASURES 2.1 X 0.9 X 1.8 CM. ON THE SKIN SURFACE THERE IS A RAISED CENTRAL LESION O.5 CM DIAMETER.S THE MARGIN IS MARKED WITH INK.  THE SPECIMEN IS SECTIONED ACROSS THE NARROW MARGIN OF THE SKIN AND THE 2 EXTREME ENDS (ELLIPTICAL END OF THE SKIN ARE SUBMITTED IN C1 WITH THE CENTRAL TISSUE IN C2). PART D RECEIVED LABELED LEFT BREAST SUPERFICIAL MARGIN IS AN IRREGULAR ELONGATED FRAGMENT OF YELLOW-PINK FATTY TISSUE MEASURING 8.5 X 2.1 X 0.5 CM IN GREATEST DIMENSION. THE SPECIMEN IS NOT OTHERWISE ORIENTED. ONE SIDE HAS A DULL APPEARANCE AND IS MARKED WITH BLUE INK. THE OPPOSITE SIDE IS MARKED YELLOW. THIS IS SECTIONED AND ENTIRELY SUBMITTED LABELBD D1 THROUGH D5. PART E RECEIVED FRESH LABELED I LEFT AXILLA SECOND SENTINEL NODE HOT,  IS AN OVOID PORTION OF YELLOW-PINK FATTY TISSUE MEASURING 2.9 X 1.7 X 1.0 CM.  SECTIONING REVEALS A 1.8 CM GROSSLY UNREMARKABLE LYMPHS NONR aHBMITTED ENTIRELY LABELED E. PATH PROCEDURES PROCEDURES: 88307/5, IMMUNOPEROXIDAS/2, A BLK/14, BBX X6, C BLK/2, D BLK/5, .EBX X6 10^Dx15 IDC FINAL DIAGNOSIS Icm 1:2g n LEFT SIMPLE MASTECTOMY: z|33 PART A  MULTICENTRIC IN SITU AND INFILTRATING DUCT CARCINOMA WITH AT LEAST FOUR SEPARATE FOCI OF TUMOR PRESENT. THE 10 O' CLOCK NODULE SHOWED IN SITU AND MODERATELY DIFFERENTIATED INFILTRATING IDC '*Dci5 den DUCT CARCINOMA, NUCLEAR GRADE III/III WITH A HIGH MITOTIC INDEX, ASSOCIATED WITH A PREVIOUS BIOPSY SITE WITH APPROXIMATELY 1.O CM OF IN I.Xcm SITU AND 1.2 CM OF INVASIVE CARCINOMA. THIS LESION EXTENDED TO WITHIN LESS THAN 1 MM OF THE SUPERFICIAL MARGIN. IN THE 11 O'CLOCK POSITION, APPROXIMATELY 1.9 CM OF INVASIVE CARCINOMA WAS PRESENT ASSOCIATED WITH 2.2 CM OF DUCT CARCINOMA IN SITU SHOWING SIMILAR NUCLEAR GRADE AND HISTOMORPHOLOGY. THIS LESION WAS 5 MM FROM THE DEEP MARGIN AND WAS
+
+--- Page 3 ---
+Patfentr. Specimen: Received: Status: Spec Type: SURGICAL p FINAL DIAGNOSIS Subm Dr: (Continuad) ASSOCIATED WITH A PREVIOUS BIOPSY SITE. EXTENDED TO THE SUPERFICIAL MARGIN. A SECTION OF BREAST TISSUE FROM THE  THE PREVIOUS BIOPSY SITE UPPER OUTER QUADRANT OF THE BREAST SHOWED APPROXIMATELY 1.1 CM OF DUCT UOQ CARCINOMA IN SITU AND O.5 CM OF INVASIVE CARCINOMA WITH SIMILAR DeIs 1DX HISTOMORPHOLOGY. AN ADDITIONAL NODULE FROM THE UPPER INNER QUADRANT OF THE BREAST SHOWED CHANGES OF A PREVIOUS BIOPSY SITE BUT NO RESIDUAL TUMOR. 1.1cm OiScm utq^-Bx a E tumr PARTS B AND E  LEFT AXILLARY SENTINEL LYMPH NODES NUMBERS 1 AND 2, BIOPSIES:  LYMPH NODES WITH NO EVIDENCE OF METASTATIC DISEASE, SUPPORTED BY NEGATIVE CYTOKERATIN IMMUNOHISTOCHEMICAL STAINING. PART C LEFT UPPER INNER CORE BIOPSY SITE, REEXCISION: SKIN AND BREAST TISSUE CONTAINING A PREVIOUS NEEDLE CORE BIOPSY SITE ASSOCIATED WITH REACTIVE FIBROSIS AND INFLAMMATION. NO RESIDUAL TUMOR IDENTIFIED. THE PART D LEFT BREAST SUPERFICIAL MARGIN, REEXCISION: Bx  NO EVIDENCE OF MALIGNANCY. ADIPOSE TISSUE WITH CODE Signed (prelim.) (signature on file) A
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diff --git a/output/text/2e4842c0-677c-466e-a47a-dd3d507b63d2.txt b/output/text/2e4842c0-677c-466e-a47a-dd3d507b63d2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..27d4a252c7fe753dc0ed0f96bd5aad2053aeaa40
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+Page 1 of 2 UUID:09055681- FB0F-4960-86A0-5D5EBD08FAED TCGA-G3-AAUZ-01A-PR Redacted CONFIDENTIAL SURGiCAL PATHOLOgy REPORT Time Collected Time Recelved Time Reported Time Transmitted Order Number Ordering Provider Status Final  Relevant Information Location Report Patlent Name:  Demographics (for verification purposes) Date of Birth: Sex: M ID0.3 Cae ntrx, heyatie lDusa N6S si7f3 SURGICAL PATHOLOGY REPORT *****Surgical Pathology Repor Sute : siur C&Q. Accession Number Collected Date/Time QO s/26/rj Received Date/Time Pathologist Specimen Description A. Gallbladder @ B. Segment 4/5 liver @ C. Final margin @ Clinical Information Hx. htc and hep B. Diagnosis A. Gallbladder, Cholecystectomy: Negative for malignancy. B. Liver, Segment 4/5, Resection: Well differentiated hepatocellular carcinoma, 4.4 x 2.7 x 2.3 cm.. 0.1 cm to the blue inked specimen margin. Background liver show portal inflammation and steatosis (2o*).. C. Final Margin, Biopsy: Liver parenchyma, negative for hepatocellular carcinoma. Reported by: Electronically signea oy: Verified: Gross Description Received are specimen containers A to c.  All remisitions and specimen containers are labelled with the patient's name, The cassettes and  identifiers are labelled with the Surgical Number A Specimen is received in formalin. The container is designated "gallbladder'@ The specimen consists of a non-intact gallbladder measuring 6.8 x 2.3 x 1.2 cm. The serosal surface appears smooth and unremarkable. The lumen contains green bile and no calculi, and the cystic duct appears patent.  The mucosa is granular, and the wall averages 0.2 cm in thickness. The cystic duct lymph node is identified and measures 0.6 cm in greatest dimension. Representative sections of the gallbladder are submitted in. Al. The entire lymph node is bisected and submitted in A2. B.  Specimen is received fresh and is submitted in formalin. The container is designated "segment 4/5 liver @ The specimen consists of an 81.3 g partial hepatectomy specimen measuring 6.4 x 6.2 x 5.6. cm. The capsular surface appears smooth and unremarkable.  Roughened surgical resection margin is dyed with blue ink.. The specimen is serially sectioned to reveal a well circumscribed, ovoid mass which has lobular features on cut surface. This mass measures 4.4 x 2.7 x 2.3 cm and grossly comes right. to the capsular surface, but does not grossly appear to invade the surface and to within 0.1 cm of the blue inked surgical resection margin. No other lesions are grossly identified.
+
+--- Page 2 ---
+ Page 2 of 2 B1-B3 representative sections of the tumor and grossly closest point of invasion to both capsular  surface and blue inked surgical resection margin. B4 further representative .section of the tumor. B5 representative section of normal liver adjacent'to the liver. C. Specimen is received fresh and submitted in formalin. The container is designated "final margin and consists of a single, soft, dark tan, triangular portion of tissue measuring 1.5 x 1.0 x 0.7 cm. Surgical resection margin is grossly identified which is dyed with blue ink. The specimen is serially sectioned and submitted in toto in one block. Pathologist Comment Case seen in review by Accesslon Number Encounter Number Patient Locatlon 1114 e oancy e is (circle
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diff --git a/output/text/2e6a20a0-087a-4075-b562-39edcb570a28.txt b/output/text/2e6a20a0-087a-4075-b562-39edcb570a28.txt
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index 0000000000000000000000000000000000000000..937a59f1e1e2dd0d29284cb706cc07781599ae7c
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+
+--- Page 1 ---
+UUID: 0A53BD62-157E-4D8D- B88A-6ACA3DAD61D0 TCGA-V4-A9ED-01A-PR Date of surgery Left eye enucleation Macroscopy The eyeball measures 27 mm main line with a posterior segment of optic nerve of 7 mm. At the section , the tumor seen measures 12 mm main line. A large number of samples have been made for cryopreservation and cytogenetic studies.. Microscopy The cut end of the optic nerve as well as the optic nerve on his entire course including the optic foramen are free of tumor. An uveal melanoma can be found, developed in the ciliary processes. The tumor is nearly only made with fusiform cells organize in short little bundles, separated by conjunctival vascular septum. The nuclear atypia are moderate. The nuclei are ovoid with a small nucleolus. There are a few mitotic figures. Some of the cells are pigmented. There is no visible endo lymphatic embolus. The tumor infiltrates the thickness of the choroid but does not infiltrates the sclera. The anterior chamber is free. Conclusion Melanoma of the choroid of the left eye , originating at the ciliary processes. Size of the tumor: 12 mm. Infiltration of the choroid.. Sclera free of tumor , optic nerve on his entire course including the cut end free of tumor LCD 03 Mearcna sprKee eQ NoS 8772/3 Lirj beoely C69 4 ut 1H5cJ13
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diff --git a/output/text/2e774938-ee96-46ec-8fa9-1e778bc5fd4b.txt b/output/text/2e774938-ee96-46ec-8fa9-1e778bc5fd4b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..78f5f7c070a5aed471c147f4c6c9e7888f93221d
--- /dev/null
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+
+--- Page 1 ---
+1Cs-0-3 Procedure Date: Ccm Oma,mfdt7ating dluc5,N0s Procedure Physician: Attending Physician/Copies To: Sifi: Buast,Nos c5O.9 UUID:81693E67-03C8-4F4D-9A60-2007058795AE TCGA-BH-A1F-01A-PR Redacted PATIeNt hISTORy:  DATE Or LMP: AGE DATE OF LAST DELIVERY: PRB~OP DIAGNOSIS: RIGHT SREAST CA POST-OP DIAGNOSIS: SAME  OPERATIVE PROCEDURE: RIGHT MODIFIED RADICAL MASTECTOMY CLINICAL HISTORY: MATERIAL SUBMITTED: RIGHT (MOD) RADICAL MASTECTOMY, PROCUREMENT BY SURGICAL PROCEDURE and axillary contents FINAL DIAGNOSIS: RIGHT MODIFIED RADICAL MASTECTONY: GRADE, 6.0 CM INTRADUCTAL CARCINOMA IS~COMEDO TYPE AND COAPRISES APPROXIMATELY: _2Ot OF TUMOR VOLUNE - MICROSCOPIC FOCI OF TUMOR IN VASCULAR SPACES INVOLVE RANDOM SECTIONS OF UPPER OUTER, LOWER INNER AND UPPER INNER QUADRANTS - METASTATIC CARCINOMA INVOLVES SIX OL THIRTY-FIVE (6/35) AXILLARY LYMPH NODES NIDPLE, NEGATIVE FOR PAGET'S DISEASE  SURGICAL MARGINS FREE OF TUMOR IN PLANES OF SECTION - RANDOM SECTIONS OF LOWER OUTER QUADRANT SHCWING FIBROCYSTIC CHANGES WITH FOCAL SEVERELY ATYPICAL DUCTAL EPITHELIAL -HYPERPLASIA NOTs: ER/pR immunoperoxidase assay will be performed on block A14.. SUPPLEMENTALREPORT IMMUNOPEROXIDASE IDENTIFICATION OF ZSTROGEN AND PROGESTERONE RECEPTORS IS CARRIED OUT ON SLIDE A14. DISTINCT INTRANUCLEAR STAINING IS IDENTIFIED FOR PROGESTERONE RECEPTOR (SOt) BUT ONLY RARELY FOR ESTROGEN RECEPTOR (104). THEREFORE, PROGESTERONZ RECEPTOR IS INTERPRETED AS POSITIVE AND ESTROGEN AS NEGATIVE. My signature below is attostation that I have roviowed all slides and agree with the findings as noted below
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diff --git a/output/text/2e8ec192-1c33-43a0-89eb-f52c925ef5f7.txt b/output/text/2e8ec192-1c33-43a0-89eb-f52c925ef5f7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ff8f6a50957e24796ec2498625f0b4dd4eed69fe
--- /dev/null
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+
+--- Page 1 ---
+ Path (First Tumor) Tumor Site: Ascending Colon Date of Cancer Sample Procurement: Histology: Adenocarcinoma Description of other histology: Grade: Well Differentiated  Yes  Mucinous: C No r Yes C Unknown (Focal) r Yes  Yes Signet Ring Feature:.  No C Unknown (Focal) Histologic Heterogeneity: 6 No C Yes C Unknown Host Response: None 3 Crohn's like reaction  None  Yes C Unknown Plasma cell rich stroma C No ( Yes C Unknown ( Expansile Growth Pattern:  Expansile ( Invasive ( Unknown and Invasive  Inflammatory Bowel Disease r No ( Yes  Unknown Angiolymphatic Invasion:  No  Yes C Unknown Mutator Phenotype: C No  Yes  Unknown Number of Slides 1  Yes Garland Necrosis present: 6 No r Yes C Unknown (Focal) TIL Cells / HPF 3.4 Pathologist Comment: UUID:1CA5DFB2-8059-4D71-862C-638393435618 TCGA-DM-A28G-01A-PR Redacted 1cs-0-3 Path- Sitxr ascndig Co{or c18.) Aw s/3/n
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diff --git a/output/text/2ea122f2-107f-4002-820b-a9257858cfa5.txt b/output/text/2ea122f2-107f-4002-820b-a9257858cfa5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c4472366d0e71c0d9f3a532d869a250d733311f5
--- /dev/null
+++ b/output/text/2ea122f2-107f-4002-820b-a9257858cfa5.txt
@@ -0,0 +1,21 @@
+
+--- Page 1 ---
+TCGA-AY-4071 SURGICAL PATHOLOGY Surgical Pathology Report Diagnosis: FsA, A: Vaginal mucosal, posterior, biopsy - Benign vaginal squamous mucosa and submucosal stroma, no carcinoma identified. B: Ovary, left, oophorectomy - Benign cysts, no carcinoma identified. C: Ovary, right, oophorectomy - Benign cysts, no carcinoma identified. D: Colon, distal sigmoid and rectum, lower anterior resection Tumor Histologic Type: Adenocarcinoma Histologic Grade: Moderately differentiated Depth of Invasion: Into submucosa. Muscularis propria present, not involved by invasive carcinoma. Lymphatic Invasion: Not identified Venous Invasion: Not identified Perineural invasion: Not identified Margins: Proximal margin: Negative Distal margin: Negative
+
+--- Page 2 ---
+Circumferential (radial) margin: Negative. Distance to closest margin: 2.0 cm (distal). Regional lymph nodes: 0/4 Additional pathologic findings: None. AJCC Stage: pT1 pN0 pMx Note: This pathologic stage assessment is based on information available at the time of this report, and is subject to change pending clinical review and additional information. E: Colon, terminal ileum and proximal right, resection - Adenomatous polyps (tubular adenomas) (4), surgical margins not involved.  No invasive carcinoma identified..  Lymph nodes, pericolic no metastatic carcinoma identified (0/8). Intraoperative Consult Diagnosis: Frozen section was requested by FsAl: Vagina, posterior, biopsy - Squamous lined fibrous nodule - No carcinoma identified Frozen Section Pathologist: Clinical History: rectal moderately differentiated adenocarcinoma, also. tubulovillous adenoma in cecum Gross Description: Specimen A was received fresh for frozen section, labeled "posterior vaginal mucosa nodule for frozen section" and consists of a 1.5 x 0.7 cm red/tan soft tissue fragment. The specimen is bisected and submitted for frozen section. in block FSA1, NTR. Specimen B is received in a formalin-filled container. labeled "left ovary" and consists of a 21.3 gram, 3.5 x 2.5 x 2.3 cm multicystic
+
+--- Page 3 ---
+ovary. The external surface is thin, smooth and almost translucent pale tan. The cut surface shows cystic multicystic structures filled with clear serous fluid. There is a small amount of fallopian tube which. measures 2.5 cm in length and 0.6 cm in cross. sectional diameter. Representative sections of ovary and tube are submitted in. blocks B1 and B2.. Specimen c is received in a formalin-filled container labeled "right ovary" and consists of a 33.0 gm, 5.0 x 4.0 x 4.0 cm multicystic ovary. The external surface of the ovary shows a large translucent cystic structure. The ovary. is bivalved to reveal a cystic structure filled with clear. serous fluid. There is a small seqment of fallopian tube, which measures 2.5 cm in length and 0.5 cm in cross sectional diameter. Representative sections of ovary. and tube are submitted in blocks c1 and c2. Specimen D:. Specimen fixation: Formalin. Parts of bowel received: Distal sigmoid colon and rectum. with a portion of perianal skin Specimen length: 26.0 cm and up to 6.0 cm in open. circumference Orientation: Inking: proximal/green, stitch marking distal anterior/red, bowel length/yellow Tumor location: Distal anterior Gross appearance of tumor: There is a superficial granular. fungating area, which measures 3.0 x 3.0 cm. In the center of this area is a surgical defect where probable tissue procurement occurred in the operating room. This defect is inked with blue ink.. Tumor dimensions: 3.0 x 3.0 x 0.5 cm. Circumferential growth: Approximately 50% of luminal circumference involved.
+
+--- Page 4 ---
+Gross depth of invasion: Tumor grossly appears to invade the submucosa but not through the muscularis propria. Gross evidence of perforation through visceral peritoneum: No Luminal obstruction: None Bowel circumference at tumor site: 6.0 cm Gross distance of tumor from margins: 2.0 cm from distal and 20.5 cm from proximal Lymph nodes: 21 lymph nodes ranging from 0.1 x 0.1 x 0.1 cm to 1.5 x 1.5 x 1.0 cm in maximum dimension. Other remarkable findings: In the central area there is a small 3mm polyp which is 12 cm from the distal end and 12. cm from the proximal end. Tissue submitted for special investigation: Tumor was taken by Dr.in the OR for tissue procurement facility and normal tissue was banked in the gross room for tissue procurement facility. Digital photograph taken: Block Summary: Inking: Distal anterior/red, proximal/green, entire length of bowel/yellow, defect in central tumor/blue D1 - Perpendicular sections of distal anterior at site of stitch and also is the closest area to tumor D2-D4 - Distal margin en face D5 - Proximal margin en face D6-D17 - Entire block tumor D18 - Small polyp D19 - Representative section of proximal colon. D20 - Two lymph node candidates D21 -- Two lymph node candidates D22  - Three lymph node candidates D23 - Three lymph node candidates D24 - Two lymph node candidates D25 Three lymph node candidates
+
+--- Page 5 ---
+D26 - Three lymph node candidates. D27 - Two lymph node candidates. D28 - Two lymph node candidates Specimen E:. Specimen fixation: Formalin. Parts of bowel received: Terminal ileum and proximal right. colon Specimen length: 25.0 cm, 12.0 cm is terminal ileum and 12.0 cm is right colon. Orientation: Inking: terminal ileum resection margin/blue,. right colon resection margin/black, inner external surface is green beneath the polyp. Tumor location: There is a pedunculated polyp in the cecum,. which measures 1.5 x 1.5 x 1.0 cm. Two tan/brown granular flat polyps in the right colon, which measures 1.5 x 1.0 x 0.2 cm and 1.2 x 0.8 x 0.1 cm. There is a 4th slightly raised polyp in the right colon, which measures 0.4 cm in diameter. Gross appearance of tumor: See above.. Tumor dimensions: There is a pedunculated polyp in the. cecum, which measures 1.5 x 1.5 x 1.0 cm. Two tan/brown granular. flat polyps in the.. right colon, which measures 1.5 x 1.0 x 0.2 cm and 1.2 x 0.8 x 0.1 cm. There is a 4th slightly raised polyp in the right colon, which. measures 0.4 cm in diameter. See above. Circumferential growth: Approximately 10% of luminal circumference involved.
+
+--- Page 6 ---
+Gross depth of invasion: Tumor does not invade the submucosa and is primarily superficial. Gross evidence of perforation through visceral peritoneum: No Luminal obstruction: None Bowel circumference at tumor site: 10.5 cm. Gross distance of tumor from margins: The polyp in the cecum is 10 cm from the colon and 13.5 cm from the terminal ileum. The closest flat polyp is. 6.7 cm from the right colon margin and the other flat polyp is 15.0 cm from the. terminal ileum margin. The smallest slightly raised polyp is 2.0 cm from the. right colon margin. Lymph nodes: 15 lymph nodes, ranging from 1 x 1 x 1 mm to 1.5 x 1.0 x 1.0 cm in maximum dimension.. Other remarkable findings: The appendix is attached and appears grossly unremarkable and measures 6.0 cm in length and up to 0.8 cm from cross. sectional diameter. There is also a blue discoloration at the right colon margin which is 1.0 cm from the margin. This area is either possible tattooing or submucosal hemorrhage. Both of these areas are submitted (E12-E14). Tissue submitted for special investigation: none. Digital photograph taken: no. Block Summary: Inking: terminal ileum resection margin/blue, right colon resection margin/black, inner external surface is green beneath the polyp
+
+--- Page 7 ---
+E1 - Terminal ileum en face E2-E3 - Right colon margin en face E4 - Tip of appendix, bisected. E5 - Representative cross sections of appendix E6-E8 - Polyps in the cecum, entirely submitted. E9 - The largest flat polyp E10 - Smallest raised polyp E11 1 Second flat polyp E12-El4 - Discolorations in the right colon E14 - Representative section of terminal ileum. E16 - Representative section of normal right colon. E17 - One lymph node, bisected. E18  - One lymph node, bisected E19  - Two lymph nodes E20 - One lymph node, bisected. E21 - Three lymph node candidates E22 - Three lymph node candidates E23  - Two lymph node candidates E24 - Three lymph node candidates P.A.: Light Microscopy: Light microscopic examination is performed by. The frozen section diagnosis is confirmed. Multiple sections show invasion into submucosa. No sections show MP invasion..
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diff --git a/output/text/2ea9a1a9-99c7-442d-a4a3-1c67df79ceb0.txt b/output/text/2ea9a1a9-99c7-442d-a4a3-1c67df79ceb0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..79f652389ce220941fdc4aecae9afc55fa936de0
--- /dev/null
+++ b/output/text/2ea9a1a9-99c7-442d-a4a3-1c67df79ceb0.txt
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+
+--- Page 1 ---
+*** Diagnosis/Diagnoses: *** Ileocolonic resection specimen including an extended, extensively ulcerated moderately differentiated adenocarcinoma of the colorectal type localized in the ascending colon with extensive infiltration of the pericolic fatty tissue and two regional lymph node metastases. Tumor-free large and small bowel resection margins. Tumor-free mesenteric resection margin. Tumor-free appendix. Tumor free omental fat tissue. Small tubular adenoma of the colonic mucosa with slight dysplasia (synonym: low-grade intra-epithelial neoplasia) additionally. Tumor stage: pT3 pN1 (2/28) pMX; G2, L0, V0 R0
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diff --git a/output/text/2ec9ca9a-e6e5-40a4-a278-5012bd0733c3.txt b/output/text/2ec9ca9a-e6e5-40a4-a278-5012bd0733c3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3371ed637daa29c2d87cb17c498f57f8db8851af
--- /dev/null
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+
+--- Page 1 ---
+Resident: Pathologi PATHOLOGIC DIAGNOSIS: ILEUM AND RIGHT COLONRIGHT COLECTOMY 30.5 Cm) ADENOcARcINOMA, low grade,moderately differentiated 4.0 cm in greatest dimension Tumor is located in the cecum with extension into the wall of the ileum, forms a fungating mass, and has a pushing border Tumor invades through the muscularis propria and into the subserosal adipose tissue. The proximal and di.stal resection margins are negative for tunor. Invasive tumor is 9 cm from proximal resection margin,21.5 cm from distal resection margin. Lymphovascular invasion is not identified. Extramural venous invasion is not identified. Perineural invasion is not identified. Peritumoral lymphoid response (including Crohn?s-like infiltrate) is moderate. Residual adenoma is present. Appendix with fibrous obliteration of lunen  negative for tumor. Diverticulosis. Regional lymph nodes positive:total:0:19. AJCc Classification T3 NO MX. CLINICAL DATA: History: Not provided. Operation: Right colectomy. Operative Findings: Not provided. Clinical Diagnosis: Right colon CA. TISSUE SUBMITTED: A.Right colon-ES rm open + return tissue bank. GROSS DESCRIPTION: The specimen is received fresh in one part, labeled with the patient's name, and unit number, and "#1. Right colon consists of a single ileocolectomy specimen including ileum (8.0 x 2.5 cm) with a proximal stapled resection margin (3.0 cm,black)colon 22.5x4.8 cm, distal resection margin, inked black, 4.0 cmand appendix (5.5 cmx0.6 cm.The specimen is opened to reveal a tan/pink ulcerating mass with raised edges (4.0 x 4.0 x 2.5 cm which is present in the cecum and appears to abut, if not involve the ileocecal valve, and is present 9.0 cm trom the proximal stapled resection margin and 21.5 cm from the distal stapled resection margin. Sectioning through the lesion demonstrates invasion into and likely through the muscularis propria. The tumor edge is locat.ed 0.4 cm from the appendix which is otherwise grossly unremarkable. The uninvolved ileal mucosa is tan/white and unremarkable. The colonic mucosa is tan/pink and contains multiple diverticula without evidence of perforation. No other lesions are identified in the specimen. Representative sections of tumor and normal colon are submitted for tissue banking. 2frags Micro Al: Proximal and distal resection maro Micro A2:Normal ileum and colon,2 frags, Page:1 of2
+
+--- Page 2 ---
+Pathology Report Micro A3-A7:Repre ive sections of tunor to deep surface, inked black,1 frag per cassette, of ileocecal valve, 1 frag, Micro A8: Representative section Micro A9:Appendix3 frags, CASE NUMBER: By his/her signature below, the senior physician certifies that he/she personally conducted a microscopic examination ("gross only" exam if so stated) of the described specimen(s) and rendered or confirmed the diagnosis(es) related thereto. Electronically signed on Final Diagnosis by Page:2of2
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diff --git a/output/text/2ed0c4cd-e5f3-4f4a-886d-08007cf4860a.txt b/output/text/2ed0c4cd-e5f3-4f4a-886d-08007cf4860a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..be1bd03bda2baf64e70867521db3c47ccb65c96e
--- /dev/null
+++ b/output/text/2ed0c4cd-e5f3-4f4a-886d-08007cf4860a.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+MRN : UUID:F6CFE506-16BA-475A-A81F-1AC4B2EFE24A TCGA-AC-A2FB-01A-PR Redacted Age: Sex DOB: Surgical Pathology Histopathological Examination Path#: Collected: Received: 1 Complete: Pre-Op Diagnosis : Absence of Rroast,Personal History Of Breast Cancer Order  Physician MD Specimens : Breast, left simple mastectomy for expo study. . Suture marking margins: long-lateral, short-superior Lymph Node,~Sentinel left axiilary. Frozen Diagnosis : Report : GROSS EXAMINATION: A. The specimen is received in a container labeled with the Elotsg name of the patient and identified as breast, left simple mastectomy. The specimen consists of a mastectomy measuring en bloc 11.5 x 9.5~x 4 cm and weighing 158 grams. There is an anterior ellipse of skin measuring~6 x 3~cm with a central 3 cm areolar complex with retracted nipple. Sections of nipple/areola are sampled in block 1.. The skin is sampled in block 2.  The superficial superior margin is inked orange and the superficial inferior margin is inked blue. The deep margin is inked green and the~specimen sectioned, showing an oval grey-tan firm mass measuring 2.8 cm in the upper inner quadrant'of the breast. Grossly, this mass is 0.4 cm from the inked deep margin of resection, which is submitted in block 3. Sections of the mass are submitted in blocks 4-7.  The remaining breast is composed. SON of yellow lobulated adipose tissue admixed with islands of gray-white rubbery tissue.  The breast is divided into four. E-9-V0/ quadrants, upper inner, lower inner, upper outer and lower. outer and sampled in blocks 8-11 respectively. Minimal axillary tissue is present and no lymph nodes are. identified.  Formalin fixation time is 11 hours. B. The specimen is received in a container labeled with the name of the patient and identified as lymph axillary sentinel node. Specimen Size: 1.8 x 1.5 x 1 cm. No. of Nodes: 1 Size of Nodes: 1.8 cm The specimen is sectioned and entirely submitted. THIS CONFIDENTIAL AND PRIVILEGED DOCUMENT/INFORMATION IS PROTECTED BY FEDERAL AND STATE LAW. UNAUTHORIZED DISCLOSURE, DISSEMINATION OR DUPLICATION IS PROHIBITED Path #:. Page 1 of 3 Visit #:
+
+--- Page 2 ---
+DIAGNOSIS BASED ON GROSS AND MICROSCOPIC EXAMINATION: Invasive lobular adenocarcinoma,pleomorphic variant,. Nottingham grade 2,"2.8 cm (see" cancer case summary checklist below). B. Lymph node, left axillary sentinel, excision:. - One lymph node. no tumor bresent (o/1). MACROSCOPIC SPECIMEN TYPE: MasteCtOmy. LYMPH NODE SAMPLING: Sentinel lymph node only. LATERALITY:Left.: TUMoR siTE: "Upper inner quadrant MICROSCOPIC SIZE OF INVASIVE COMPONENT: Greatest dimension: 2.8 cm (based on gross tumor size). HIsroLogic Type: Invasive lobular~adenocarcinoma? . pleomorphic variant. HISTOLOGIC GRADE: NOTTINGHAM HISTOLOGIC SCORE Tubule formation: Minimal less than 10% (score-3) Nuclear pleomorphism: Moderate increase in size, ect. (score=2) Mitotic count for a 40 x objective with a field area of 0.152 mm: 0-5 mitoses per 10 hpr (score=1) Total Nottingham Score: Grade 2 (6-7 points). EXTENT OF INVASION PRIMARY TuMOR (PT): pT2: Tumor more than 2.0 but not more than 5.0 cm in greatest dimension. REGIONAL LYMPH NODES (PN): pNO: No regiOnal lymph node metastasis histologically (i.e. none greater than 0.2 mm).. no additional examination for isolated tumor cells. Number examined: 1 Number involved 0. DISTANT METASTASIS(PM) : pMX: Cannot be assessed. MARgiNs: Uninvolved by invasive carcinoma. Distance of carcinoma from closest margin: 4 mm (deep margin). VENOUS/LYMPHATIC (LARGE/SMALL VESSEL) INVASION (V/L): AbSent.) MIcRocALCIFIcATIoNS: Present in non-neoplastic tissue. ADDITIONAL PATHOLOGIC FINDINGS: Proliferative fibrocystic changes with ductal hyperplasia, presence of p63 positive myoepithelial cells surrounding epithelial structures, with appropriate controls). apocrine metaplasia, and associated microcalcifications. THIS CONFIDENTIAL AND PRIVILEGED DOCUMENT/INFORMATION IS PROTECTED BY FEDERAL AND STATE LAW. UNAUTHORIZED DISCLOSURE, DISSEMINATION OR DUPLICATION IS PROHIBITED Page 2 of 3 Path #: Visit #:
+
+--- Page 3 ---
+Prior bsopsy site. COMMENT : Estrogen and progesterone receptors and Her2neu studies were performed on the prior biopsy : with results of estrogen receptor 2+, progesterone  receptor 3+, and HER2/neu negative, confirming a'lobular phenotype. Intradepartmental consultation obtained Results communicated to Pathologist Electronically Signed by: THIS CONFIDENTIAL AND PRIVILEGED DOCUMENT/INFORMATION IS PROTECTED BY FEDERAL AND STATE LAW. UNAUTHORIZED DISCLOSURE, DISSEMINATION OR DUPLICATION IS_PROHIBITED ( 1: Path #: Page 3 of 3 Visit #:
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diff --git a/output/text/2ed6abc3-db6d-4f52-9202-103c61f14622.txt b/output/text/2ed6abc3-db6d-4f52-9202-103c61f14622.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b6b45781e1a720225178286ba94432f7a45bf2fa
--- /dev/null
+++ b/output/text/2ed6abc3-db6d-4f52-9202-103c61f14622.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+p.12 33 AGNOSIS: RIGHT BREAST. SIMPLE MASTECTOMY INVASIVE LOBULAR CARCINOMA,S5 CM WITH SIGNET RINC FEATURES, NOTTINGHAM SC:ORE 6 /9, A. (TURULES -3, NUCLET- 2, MITOSES-I): NOTLINGHAMGRADE: 2. B. C:. 1.YMPHOVASCULAR SPACEINYOLMEMENEIS D. LOBIILAR.CARCINOMAINSI E. CMOR G LEROSING ADENOSIS SHMORT PART 2RTOHIAX ONEOFTWO (Sc comment) PART 3: RIGHT AXILLA SENHNEL EYMPE  ONE LYMPH NODE NECATIVE FOR TUMOT PART 4: RIGAT AXILLA, SENTINEL LYMPH NODE #3, EXCISIONS ONE LYMPH NODE NEGATIVE FOR TIMOR. CASE SYNOPSIS: SYNOPTIC - PRIMARY INVASIVE CARCiNOMA OF SREASTE LAtERALITy: PrOceDure: Right LOCATION: Smple mastectomy SIZE OF TUMOR: Central subareolar MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:E Maximum dimension invasive component: 5.5 cm TUMOR TYPE (invasive component): No Histologic type:  Infillrating lobular carcinoma 1cs-0-3 Classical, Signet ring NOttingham scOre: sacinom, mfittraHay 1obulev,nor 852of3 Nudear grade: 2 Tubule formation: 3 Sih: brst;N1s c5v.9 63/13/n sw Mltotic activity score: 1 Total Nottingham score: 6 ANGIOLYMPHATIC INVASION: Notlingham grade (1, 2, 3): 2 DERMAL LYMPHATIC iNVASION: No CALCIFICATION: No Yes, benign zones TUMOR TYPE, iN SITU: Yes, malignant zones LCIS SURGICAL MARGINS iNVOLVED BY iNVASIVE COMPONENT:E Percent of tumor occupied by in situ component: 2 % SURG MARGINS INVOLVED BY IN SITU COMPONENT: No Paget's Disease of nIpple: Na No Lymph nodes positive: UUID:F04188AB-51CE-4AA1-B72C-3998E7863235 TCGA-BH-A0DP-01A-PR Redacted 0 Lymph nODeS EXAMInED: METHOD(S) OF LYMPH NODE EXAMINATION: 4 H/E stain, Keratin stain SENTINEL NODE METASTASIS: Yes OnLy KERATIN POSITiVE CELLS ARE PRESENT: Yeb SIZE OF NODAL METASTASES: Diamelar of largest lymph node metastasis: 0.15 mm. Lymph nODe MeTASTASIS(-ES) with eXTrACApSULAR EXTeNsiON: SKIN INVOLVED (ULCERATION): No NON-NEOPLA$TiC BREAST TISSUE: FCD, Other: Sclerosing adenosis. No t Stage, pathoLOgIC: N Stage, PatholOgIC: p`T3 m stage, pathologic: pN0(i+) ESTROGEN RECEPTORS: pMX PROGESTEROnE RECEPTORS: positive HERZ/NEU: positive zero or 1+ circle N. 3/43/#
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diff --git a/output/text/2ede69ac-3fe9-48ef-8653-b96bd4f28cab.txt b/output/text/2ede69ac-3fe9-48ef-8653-b96bd4f28cab.txt
new file mode 100644
index 0000000000000000000000000000000000000000..bfc3dbddbb4f2474c627a07a2ba5c71fd6c68ccb
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+
+--- Page 1 ---
+1c0 -0 - 3 UUID:DA82E751-09C3-466E-A63A-38368D8A2C7 TCGA-A2-A1G0-01A-PR Redacted Phone C$CF.Ste: buxst, Nos C50.9 Tax. Name: Acct#: Unit#: Age/Sex: Reg: Location: Status: Disch: Att Dr: Roam/Bed: Speciman:d Received: Spec Type: SURGICAL P Status: Subm Dx: LEFT BREAST CANCER INVASIVE/RIGHT MAMMOGRAPHIC ABNORMALITY DATE : DOcTOR(s) : PROCEDURE :  MASTECTOMY COMPLETE SIMPLE WITH SENTINEL  NODE BX A.J LT BREAST SENTINEL NODE #1 - FS B. LT BREAST MASTECTCMY c. RT BREAST MASTECTCMY D. LT AXILLARY NODE DISSECTIONS E. LT BREAST INFERIOR LATERAL SUPERFICIAL MARGIN F. RT AXILLARY SKIN A. METASTATIC CARCINCMA PART A RECEIVED FRESH LABELED SENTINEL NODE, IS AN OVOID PORTICN OF RED-TAN TISSUE MEASURING 1.7 X I.1  LEFT MASTECTOMY FIRST X 1.O CM.SECTIONING REVEALS A PINK-TAN TO GRAY-WHITE CUT SURFACE.  A REPRESENTATIVE SECTION IS SUEMITTED AS FSA (MIRROR IMAGE TO PROTOCOL). THE REMAINDER OF THE NODE IS SUBMITTED LABELED A. PART B  RECEIVED LABELED O'CLOCK, IS A SIMPLE MASTECTCMY MEASURING 25 X 20 X 4.5 CM.  THE NIPPLE LEFT MASTECTCMY STITCH AT 12 IS UNREMARKABLE AND SITS WITHIN A 1O X 4.5-CM SKIN ELLIPSE. A SUTURE DENOTES 12 O'CLOCK. THE SUPERFICIAL ASPECT IS MARKED WITH BLUE INK. THE DEEP WITH Q\OCK_. SECTIONING REVEALS THE CENTRAL ASPECT OF THE SPECIMEN TO CONSIST OF DENSE TAN FIBROUS TISSUE WITH AN OVOID TAN FIRM AREA IN THE 11_O'CLOCK AREA, WHICH MEASURES 4.5 CM FRCM MEDIAL TO LATERAL, 2.5 CM FRCM SUPERIOR TO INFERIOR, AND 2.O CM FRCM SUPERFICIAL TO DEEP. THIS IS 1.3 CM FRCM THE DEEP MARGIN. ADDITIONAL FIRM AREAS ARE NOTED. ONE IS AT 12 O'CLOCK SLIGHTLY INFERIOR TO THE PREVIOUSLY DESCRIBED LESION MEASURING 1.1 CM IN DIAMETER. GROSSLY THIS IS 1 CM FRCM THE 1I O'CLOCK LESION. A COIL CLIP IS IDENTIFIED IN THE 11 O'CLOCK LESION. THERE IS A O.7 CM IN DIAMETER LESION, WHICH IS O.8 CM FRCM THE DEEP IN THE 9 O'CLOCK AREA,
+
+--- Page 2 ---
+Chiat of Pathology Phon- Tax Patient: (Continued) Specimen: Received: Status: Spec Type: SURGICAL P Subm Dr: (Continued) MARGIN AND 1.5 CM FRCM THE 11 O'CLOCK LESION. B1---NIPPLE, B2--11 O'CLOCK LESION (MIRROR IMAGE TO PROTOCOL IN AREA OF CLIP, B3--I1 O'CLOCK LESION B5--9 O'CLOCK NODULE, B6--9 O'CLOCK AREA SUPERFICIAL TO B5, B7---THE MOST MEDIAL ASPECT OF THE 11 O'CLOCK LESION, B8--THE MOST LATERAL ASPECT OF THE 11 O'CLOCK LESION (4.5 CM FROM B7), B9 AND 1O--FULL CROSS SECTION OF 11 O'CLOCK LESION, B11--SECTICN OF UPPER INNER QUADRANT SUPERFICIAL TO THE 9 O'CLOCK LESION WITH QUESTIONABLE LESIONAL TISSUE, B12---UPPER INNER QUADRANT NODULARITY SUPERFICIAL TO THE PREVIOUSLY DESCRIBED 9 O'CLOCK LESION AND SUPERIOR TO B11, B13--LOWER INNER QUADRANT, B14---LOWER OUTER QUADRANT, B15--UPPER OUTER QUADRANT. PART C RECEIVED LABELED RIGHT MASTECTOMY STITCH AT 12 O'CLOCK, IS A SIMPLE MASTECTOMY SPECIMEN MEASURING 28.5 X 23 X 3.5 CM. THE NIPPLE IS UNREMARKABLE WITHIN A 9 X 4.2-CM SKIN ELLIPSE. THE SUPERFICIAL ASPECT IS MARKED WITH BLUE INK.  THE DEEP MARGIN WITH BLACK INK.  A SUTURE DENOTES 12 O'CLOCK. SECTICNING REVEALS THE CENTRAL ASPECT OF THE BREAST TO CONSIST OF PALE YELLCW-TAN FIBROUS TISSUE WITH A PERIMETER OF YELLOW FATTY TISSUE, WHICH IS PREDCMINANTLY ON THE LATERAL ASPECT. NO DISTINCT LESIONS ARE PALPATED WITHIN THE SPECIMEN. THERE IS AN AREA WITH RED DISCOLORATICN SUGGESTIVE OF A BIOPSY AREA IN THE UPPER OUTER QUADRANT AND A COIL CLIP IS IDENTIFIED. NO ADDITIONAL NODULES ARE IDENTIFIED. SECTIONS ARE SUEMITTED AS FOLLOWS: CI--NIPPLE, C2--CENTRAL DEEP MARGIN, C3 AND 4--UPPER INNER QUADRANT, C5 AND 6--UPPER CUTER QUADRANT, C7 AND 8--LOWER CUTER QUADRANT, C9 AND 1O--LOWER INNER QUADRANT, C11 THROUGH 13--ADDITIONAL SECTIONS FRCM 9 O'CLOCK AREA. NOTE THAT C1, C3, C5, C7, AND C9 ARE MIRROR IMAGE TO SECTIONS TAKEN PER PROTOCOL. NOTE THAT C5 IN AREA OF COIL CLIP. PART D RECEIVED LABELED LEET AXILLARY NODE DISSECTION, IS YELLON-RED FATTY TISSUE MEASURING 9.5 X 7.5 X 2.0 CM. THIS IS EXAMINED FOR LYMPH NODES. THE LARGEST NODE MEASURES 4.O CM IN GREATEST DIMENSIONS AND DFMONSTRATES CENTRAL FAT REPLACEMENT.  SECTICNS ARE SUBMITTED AS FOLLOWS: D1--THREE NODES EACH BISECTED, D2-~TWO NODES EACH BISECTED, D3--ONE NODE BISECTED, D4--ONE NODE BISECTED, D5--ONE NODE BISECTED, D6--CNE NODE BISECTED, D7--CNE NODE, D8---ONE NODE, D9 THROUGH D12--ONE NODE TOTAL, D13--FOUR NODES, D14--ONE NODE BISECTED, D15--ONE NODE BISECTED, D16--ONE NODE BISECTED, D17--ONE NODE BISECTED. PART E RECEIVED LABELED  LEFT INFERIOR AND LATERAL SUPERFICIAL MARGIN REEXCISICN STITCH AT NEW MARGIN, IS AN IRREGULAR FLAT PORTION OF YELLOW-PINK FATTY TISSUE MEASURING 15.5 X 10.5 X 1.4 CM IN GREATEST DIMENSIONS. A SUTURE DENOTES THE NEW MARGIN AND THIS SIDE IS MARKED WITH BLUE INK. REPRESENTATIVE SECTICNS ARE SUBMITTED LABELED E1 THROUGH 10. APPROXIMATELY 25t OF THE SPECIMEN IS SUBMITTED.
+
+--- Page 3 ---
+Chief of Pathology Phone Iax 1 Patient: (Continued) Specimen: Reoeived: Spec Type: SURGICAL P Status: Subm Dr: (Continued) PART F RECEIVED LABELED AN ELLIPTICAL PORTION OF TAN SKIN MEASURING 3.3 X 1.5 X O.7 CM. . THIS IS RIGHT AXILLARY SKIN TISSUE, IS NOT OTHERWISE ORIENTED. THE SURFACE MEASURING O.7 CM IN LENGTH. THE MARGIN IS MARKED WITH BLACK THERE IS A FULL~THICKNESS SLIT-LIKE DEFECT ON INK WITH THE SLIT-LIKE DEFECT MARKED BLUE. NARROW MARGIN AND SUBMITTED SEQUENTIALLY LABELED F1 AND 2.  THIS IS SECTIONED ACROSS THE PROCEDURE S : 88307/3, 88309, PATH FS , A BLK, B BLK/15, C BLK/13, D BLK/17, E BLK/1O, F BLK/2, FS-A PART A LEFT AXILLA, SENTINEL LYMPH NODE BIOPSY NUMBER 1: METASTATIC CARCINCMA CONSISTENT WITH BREAST PRIMARY HAVING A MAXIMUM MICROSCOPICS DIMENSION OF 8 MM AND SHOWING EXTRANODAL EXTENSION. PART B LEFT BREAST, SIMPLE MASTECTOMY: 1. WELL-DIFFERENTIATED.. INFILTRATING TUBULOLOBULAR. CARCINOMA, NUCLEAR GRADE 1, LOW MITOTIC INDEX AND TUBULE FORMATION 2 WITH TOTAL NOTTINGHAM SCORE OF 4. 2. LARGEST GROSS TUMOR INVOLVES THE_11 O'CLOCK AREA MEASURING 4.5 CM IN GREATEST DIMENSION. ADDITIONAL SIMILAR TUMOR NODULES ARE MULTIFOCALLY NOTED WITHIN THE SAME QUADRANT AT THE 12 O'CLOCK, 9 O'CLOCK, SUPERFICIAL UPPER INNER QUADRANT AND SUPERIOR UPPER INNER QUADRANT RANGING FRCM O.5 TO 1 CM IN GREATEST MICROSCOPIC DIMENSION.S 3. THE NIPPLE SKIN, RANDOM SECTIONS OF THE REMAINING QUADRANTS AND MARGINS OF EXCISION ARE FREE OF TUMOR. 4. LYMPHOVASCULAR INVASION IS PRESENT. 5. THE BIOPSY SITE IS IDENTIFIED. 6. PROLIFERATIVE FIBROCYSTIC CHANGES ARE SEEN IN RANDCM SECTIONS FROMS THE REMAINING QUADRANTS. PART C RIGHT BREAST, SIMPLE MASTECTOMY: PATCHY AREAS OF PSEUDOANGICMATOUS HYPERPLASIA AND FIBROCYSTIC CHANGES INCLUDING USUALS DUCTAL HYPERPLASIA, APOCRINE METAPLASIA, MICROCYST FORMATION AND PATCHY DENSE STRCMA. BIOPSY SITE IS PRESENT.  NEGATIVE FOR
+
+--- Page 4 ---
+Chief of Pathology Phone Iax Patient: (Continued) : Reoeived: Status: spec Type: SURGICAL P Sub Dr: (Continued) EPITHELIAL ATYPIA. PART D LEFT AXILIA, LYMPH NODE DISSECTION: METASTATIC BREAST CARCINCMA IS IDENTIFIED IN 1 OF 18 LYMPH NODES EXAMINED WHICH HAS FOCAL INVASION INTO THE PERINODAL FAT. PART E LEFT BREAST, REEXCISION OF LEFT INFERIOR AND LATERAL SUPERFICIAL MARGINS: FATTY BREAST TISSUE WITH NO EVIDENCE OF RESIDUAL TUMOR AND CLEAR MARGIN. PART F SKIN, RIGHT AXILLA, BIOPSY: FOCAL SUPRABASAL DETACHMENT OF THE EPIDERMIS WITH ASSOCIATED CAUTERY ARTIFACT. NO EVIDENCE OF NEOPLASM OR SIGNIFICANT INFLAMMATION. Sigred (signature on file) Pw TSS,TC6A tunr is nifiHtuHNg ou+l, nvtlobula. faHl dx cirory
+
+--- Page 5 ---
+V4.00 TCGA Pathologic Diagnosis Discrepancy Form Instructions: The TCGA Pathologic Diagnosis Discrepancy Form should be completed when the pathologic diagnosis. documented on the initial pathology report for a case submitted for TCGA is inconsistent with the diagnosis provided on the Case Quality Control Form completed for the submitted case. Tissue Source Site (TSS): TSS Identifier: _  TSS Unique Patient Identifier: Completed By (Interviewer Name Completed Date: _ Diagnosts Information Data Element Entry Alternatives # Working Instructions Provide the diagnosis/ histologic subtype(s) documented on. Pathologic Diagnosis Tutulolobular Ca. the initial pathology report for this case. If the histology for this case is mixed, provide all listed subtypes.. Provided on Initial  Pathology Report Histologic features of Provide the histologic features selected on the TCGA Case Quality Control Form completed for this case.e the sample provided for TCGA, as reflected  on the CQCF. Discrepancy between Pathology Report and Case Quality Control Form  Provide the reason for  Provide a reason describing why the diagnosis on the initial TubuloitulakCa daqncse pathology report for this case is not consistent with the. the discrepancy diagnosis selected on the TCGA Case Quality Control Form.  between the pathology at qutside instituhinn. report and the TCGA Case Quality Control 1HC stzuning done ty Form. Qnd Rcael ty Supp0r+S 1DC cHiagmosis.  Name of TSS Reviewing  Provide the name of the pathologist who reviewed this case. for TCGA. Pathologist or Biorepository Director I acknowledge that the above information provided by my institution is true and correct and has been quality controlled.. TSS Reviewing Pathologist or Biorepository Director. Date I acknowledge that the above information provided by my institution is true and correct and has been quality controlled. The Attending Pathologist or the Department Chairman has been informed or is aware of the above discrepancy in diagnoses.. Principal Investigator Signature. Date
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diff --git a/output/text/2ee9815b-660f-4b74-80cc-f0b8e6a1cb9d.txt b/output/text/2ee9815b-660f-4b74-80cc-f0b8e6a1cb9d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9f0d47c592657824fd9c34e959e0b22cd6284566
--- /dev/null
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+TCGA-A3-3376 Collected: Accession Received: Acct/ Reg Reported: MWSAWSURGICALPATHOLOGYREPORT RW DIAGNOSIS: Left kidney, radial nephrectomy Renal carcinoma. Tumor Characteristics: 1. Histologic type: Clear cell adenocarcinoma 2 Tumor site: Upper pole. 3. Tumor size: Up to 2.5 cm maximal diameter. 4. Macroscopic extent of tumor: Limited to kidney.. 5. Nuclear grade: Fuhrman grade: 2/4. 6. Lymphovascular space Invasion: Not Identified.. 7.  Transcapsular Invaslon: No.  Renal veln Invasion: No. 9. Venacava invaslon: Not resected. 1 0, Adrenal gland: Present, negative for tumor.. Surgical Margin Status: 1. Soft tissue margins: Negative for tumor.. 2. Ureteral margin: Negative for tumor. 3. Vascular Margin: Negative for tumor. Lymph Node Status: 1. No lymph nodes Identified. Other Significant Findings:  The background non-neoplastic kidney shows pronounced arteria! and arteriolonephrosclerosis as well as nodular glomerulosclerosis. Muitiple specimens stains will be performed to further evaluate these changes, with an addendum report to follow. 2. pTNM stage: T1NOMX. Staging sheet Electronic Signature: COMMENTS: has reviewed the case and concurs with the diagnosis.. CLINICAL INFORMATION
+
+--- Page 2 ---
+CLINICAL HISTORY:S Preoperative Diagnosis: CA left kidney.. Postoperative Diagnosis: Symptoms/Radiologic Findings:e SPECIMENS: Left kidney. Gross DescriptIOn: The specimen is received in a single container labeled with the patient's name,  st *.. The specimen consists of a kidney with attached. perinephric fat measuring 20.0 x 10.0 x 5.5 crn, weighing 463 gm. There is an attached adrenal gland that measures 3.0 x 1.0 x 1.0 cm. The cut surface. is golden yellow and shows a well demarcated cortex and medulla. There are no lesions identified. The soft tissue margin has been inked. The ureter stump is identified, measuring 6.0 cm in length and 0.3 cm in diameter. The surface is gray to pink-tan. On sectioning the ureter the mucosal surface is. yellow to gray-tan and smooth. There are no lesions seen grossly. The renal artery stump measures 0.7 cm in length and 0.5 cm In diameter, is slightly atherosclerotic but grossly unremarkable. The renal vein stump measures 0.7 cm in length and up to 1.0 cm in diameter and is grossly unremarkable. The kidney is bisected and reveals a circumscribed, golden yelow mass within the upper pole that measures 2.5 x 2.5 x 0.5 cm. The mass is confined. to the capsule with no invaslon into the surrounding perinephric fat. The renal pelvis and calices are gray-tan, smooth, and are uninvolved by the mass. There are multiple small, brown-tan calcull noted within the calices. There are no other leslons identified. The surrounding renal cortex is brown-tan and measures 0.5 cm In greatest dir. displays a well demarcated coriex and renal pyramids. Received with the specimen are two cassettes, one green and one yellow, labeled.  Repressntative sections are submitted in cassettes Jas follows: Sections from mass in blocks 1 through 4; sections from surrounding uninvolved renal cortex in block 5; ureter block 6; renal artery and vein block 7; adrenal block 8..
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diff --git a/output/text/2eee9a28-f5cd-41d9-910d-996fb0877284.txt b/output/text/2eee9a28-f5cd-41d9-910d-996fb0877284.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6836a0e8fe44946eb21e3ed2ee9e6b06eeb5904b
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+1cD-0 -3 850o/3 Csrcmoma nfittratny ouctl, nes PcH Sitii Bustj y0Q C50.y CQcF 9it: Busst,nos Cso.9 Diagnosis: 1. Breast segment with a bifocal invasive ductal carcinoma (G Il; tumor diameter: 3 cm and 0.8 cm) with focal intraductal components.. Tumor classification: NOS, G Il, pT2(m) pN1a(1/18)L0V0R0 UUID: 2243F29C-191C-4D33-8483-09BB3AD365980 CGA-A8-A07J-01A-PR Redacted
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diff --git a/output/text/2f193afb-0c4a-4237-bff3-7dbe0b02f3d1.txt b/output/text/2f193afb-0c4a-4237-bff3-7dbe0b02f3d1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..653e6bdecf4d52d152d1e8585260c7d90f38b809
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+No clinical history is given.. PRE-OP DIAGNOsIS: Right kidney mass. POST-OP DIagNOSIS: Same. DEDURE: Right nephrectomy. FINAL DIAGNOSIS: Kidney, right, nephrectomy --  RENAl CELL CArcINOmA, COnVenTIONAL (CLEAR) CELl TypE FUHRMAN' S NUCLEAR GRADE IS 2 OF 4 C.  The greatest diameter of the neoplAsm is 4 cm.. D. THE NEOPLASM IS CONFINED WITHIN THE RENAL CAPSULE E.  NO INVASION OF THE RENAL VEIN IS IDENTIFIED F. NO eVIDeNCE OF ANGgIOLympHATIC inVASION IS IdenTIfIeD. G. ALL SURGICAL MArGINS ARE FrEE OF THe NEOPLASM H. THE NON-NEOPLASTIC KIDNEY IS UNREMARKABLE I. THE ADRENAL GLAND IS UNREMARKABLE J. TNM STAGE: pT1a Nx MX. K. Tnm histologic grade - G2.s COMMENT: A panel of immunohistochemical stains has been performed, which showed the tumor cells to be strongly positive tor CD10, and weakly positive for RcC and E-cadherin. Tumor cells are focally positive for cytokeratin 7 and negative for Ber- EP4. A colloidal iron stain was also negative. This staining pattern supports a diagnosis of conventional type renal cell carcinoma. Case synopsis: SYNOPTIC DATA - PRIMARY KIDNEy TUMORS SPECIMEN TYPE:  Radical nephrectomy LATERALITY: Right TumOr site: Middle FOCALITY: Unifocal TUMOR SIZE: Greatest dimension: 4.0 cm Additional dimensions: 3.5 cm MACrOScOpIC eXTeNt Of TUmOR:  Tumor limited to kidney HISTOLOGIC TyPE: Clear cell (conventional) renal carcinoma HISTOLOGIC GRADE (Fuhrman Nuclear Grade): G2 PATHOLOGIC STAGING (pTNM): pT1a pNX Number of regional lymph nodes examined: 0 pMX MARGINS: Margins uninvolved by invasive carcinoma ADRENAl GLAND: Uninvolved by tumor VEnoUs (LArge VEsseL) invasion (V): Absent LymphaTIC (SmaLL VESseL) inVasiOn (L): Absent ADDITIONAL PAThOLOGIC FINDINGS: Glomerular disease (type): Minimal global glomerusclerosis.
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diff --git a/output/text/2f79f3cd-5367-457f-8255-bb15d46b1602.txt b/output/text/2f79f3cd-5367-457f-8255-bb15d46b1602.txt
new file mode 100644
index 0000000000000000000000000000000000000000..570bb96c482c2b5e4f2d92e9c4c4bff4c3a29639
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+UUID:1FECADEA-0B65-451D-933D-2217F9119035 TCGA-OR-A5O-01A-PR Redactedd Dellver To: IcD63 Carcinomo, adreua) ssrtio) 837c[3 Site Adreual 6and,cartex CH4.D Received 9tO 1/3o/i3 A HISTOPATHOLOGY FOR REVIEW T 0 Slides were reviewed at the request of. reating surgeon). This L review is part ot a project examining comparative genomic hybridisation on 0 adrenal tissue frozen at the time of surgery and involves centrallsed G histopathological review including assignment of a Weiss score to a large number of adrenal tumours. Y Macroscopic: The specimen labelled 'right adrenal gland" consists of a partly incised. adrenal gland, from which a piece of tissue has been removed, weighing 55g and measuring 60mmx40mx30mm. It is largely replaced by a haemorrhagic tumour  measuring 50mmx50rmmx30mm. 6 Blocks Sampled. MICROSCPIC: At least 2 Weiss criteria are present (Diffuse architecture, Eosinophilic cytoplasm). A In addition there is probable venous invasion (present in block 1). There iss. N some necrosis (present in block 5) but this appears to be of infarct like A necrosis rather than coagulative necrosis. There is some nuclear enlargement and hyperchromasia but I do not think this qualified as nuclear atypia by the. T Weiss criteria. There is no signiflcant mitotlc activity. Atypical mitoses. are not present. 0 M I would classify this as an Adrenal Cortical Turnour of uncertain malignant potential. As I am uncertain how to apply the Weiss criteria in this case, ! 1 shall send the slides to :or his expert opinion. c A SUMMARY: Adrenal Gland: Adrenal cortical tumour of uncertain malignant potential. An. L additional report clarifying the number of Weiss criteria is pending. P T-93000 M-81400 A ADDITIONAL REPORT: T Slides were sent to or consultation. Dr reports: H 0 L Ipane 1 nt 2| 0
+
+--- Page 2 ---
+Requesting Doctor's Information: Deliver Tc .O_A Received A HISTOPATHOLOGY FOR REVIEW T H 0 The sides submitted show an unencapsulated adrenocortical neoplasm with a L diffuse growth pattern. The cells have predominantly eosinophilic cytoplasm.. Broad fibrous bands are present. Nuclear hyperchromasm and pleomorphism is 0 noted (nuclear grade 3 according to Fuhrman's criteria). Vascular invasion is G identified on slide 5. No definite necrosis is identified. Rare mitotic tigures (2/50HPFs) are seen on the submitted six slides. No atypical mitotic tigures Y are seen. No sinusoidal or capsular invasion is seen. Utilising the Weiss criteria (American Journal of Surgical Pathology, Volume 8 (3): 163-169, 1984), this neoplasm (1 for vascular invasion, 1 for nuclear grade 3, 1 for diffuse architecture, and 1 for <=25% clear tumour cells). Therefore, this neoplasm would be classified'as a malignant nsoplasm. Furthermore, the presence broad fibrous band is used as one feature associatedn. with malignant adrenocortical tumour by Hough's criteria (Hough et al, American Journal of Clinical Pathology, 72:390-39g, 1979). A As you mentioned, there is a small focus of adrenocortlcal tissue is the N peri-adrenal fat tissue in block 1. We think this is ectopic normal adrenal A cortical tissue. A small infarct-like area is identified in block 5 as you mentioned, and we agree with your interpretation. We think that it does not T represent coagulative necrosis. 0 The attending pathologist whose signature appears on this report has reviewed M the slides and has edited the gross/or microscopic portion of the report in rendering the final microscopic diagnosis. 1 c DIAGNOSIS: Adrenal mass, right adrenolectomy A - Adrenocortical carcinoma, low grade - Vascular invasion identified L  - No capsular invasion or extracapsular extension identified P A T REPORTING PATHOLOGIST: H (Electronic Signature) 0 L 0 Page 2 of 2 Y Where'Collected indicates Rec:
+
+--- Page 3 ---
+Patient: rvico operctad by Loc: REPORT Dob/Age Doctor: ests requested: Tests to follow. CLINICAL NOTES:  Right laparoscopic adrenalectomy MACROSCOPIC: Dr Specimen labelled "Right adrenal gland" -- Consists of a partly incised adrenal gland, from which a. piece of tissue has been removed, weighing 55g and measuring 60mmx40mmx30mm. It is largely. replaced by a haemorrhagic tumour measuring 50mmx50mmx30mm. MICROSCOPIC: The sections show an adrenal gland. The lesion is composed of cells recapitulating the adrenal cortex. There are areas of haemorrhage and pigment containing cells. There is no significant nuclear. pleomorphism, mitotic activity, areas of necrosis or capsular or vascular invasion noted. Cells with clear cytoplasm are also present. The appearances are consistent with an adrenal cortical adenoma. CONCLUSION: RIGHT ADRENAL GLAND: Cortical adenoma. electronic signature) Reported by:
+
+--- Page 4 ---
+Patient: Dob/Age: Doctor: rests requesred: HISTO Tests to follow; <none> CLINICAL NOTES: Right laparoscopic adrenalectomy MACROSCOPIC: Dr Specimen labelled "Right adrenal gland"' -- Consists of a partly incised adrenal gland, from which a piece of tissue has been removed, weighing 55g and measuring 60mmx40mmx30mm. It is largely replaced by a haemorrhagic tumour measuring 50mmx50mmx30mm. MICROSCOPIC: The sections show an adrenal gland. The lesion is composed of cells recapitulating the adrenal cortex. There are areas of haemorrhage and pigment containing cells. There is no significant nuclear pleomorphism, mitotic activity, areas of necrosis or capsular or vascular invasion noted. Cells with clear cytoplasm are also present. The appearances are consistent with an adrenal cortical adenoma. CONCLUSION: RIGHT ADRENAL GLAND: Cortical adenoma. Reported by: electronic signature) FURTHER REPORT: Slides from this case were reviewed as part of a study utilising comparative hybridization to compare the genotype of benign and malignant adrenal cortical neoplasms. Patient and ethics committee approval etc have been obtained. The study requires centralised pathology review and for all cases to be given a Weiss score. I have reviewed most of the cases, although difficult or borderline cases have been referred to I thought that this case some atypical features including a diffuse architecture and less than 25% clear cells. I was unsure whether this should be given a point for cytology atypia, yascular space invasion or diffuse architecture. I noted that there was no significant mitotic activity..
+
+--- Page 5 ---
+Dob/Age REPORT Doctor. ests requesred Tests to follow: As it was a borderline case slides were referred to who considers it a low grade  adrenocorticol carcinoma. A copy of his report is included. I shall return the slides as soon as we receive them back. Reported by FURTHER REPORT: The slides submitted show an unencapsulated adrenocortical neoplasm with a diffuse growth pattern. The cells have predominately eosinophilic cytoplasm. Broad fibrous bands are present. Nuclear hyperchromasm and pleomorphism is noted (nuclear grade III according to Fuhrman's criteria). Vascular invasion is identified on slide 5. No definite necrosis is identified. Rare mitotic figures (2/50HPFs) are seen on the submitted six slides. No atypical mitotic figures are seen. No sinusoidal or capsular invasion is seen. Utilising the Weiss criteria (American Journal of Surgical Pathology, Volume 8 (3): 163-169, 1984), this neoplasm would rate a score of 4 (1 for vascular invasion, 1 for nuclear grade 3, 1 for diffuse architecture, and 1 for <-25% clear tumour cells). Therefore, this neoplasm would be classified as a malignant neoplasm. Furthermore, the presence broad fibrous band is used as one feature associated with malignant adrenocortical tumour by Hough's criteria (Hough et al, American Journal of Clinical Pathology. 72:390-399, 1979). Due to the low mitotic rate, this numour is low grade malignant. As you mentioned, there is a small focus of adrenocortical tissue in the peri-adrenal fat tissue in block 1. We think this is ectopic normal adrenal cortical tissue. A small infarct-like area is identified in block 5 as you mentioned and we agree with you interpretation. We think that it does not represent coagulative necrosis. The attending pathologist whose signature appears on this report has reviewed the slides and has edited the gross and/or microscopic portion of the report in rendering the final microscopic diagnosis.
+
+--- Page 6 ---
+Dob/Ag REPORT Doctor: Tests requcsred! Tests to follow: ~ DIAGNOSIS: ADRENAL MASS, RIGHT ADRENOLECTOMY : -ADRENOCORTICAL CARCINOMA, LOW GRADE -VASCULAR INVASION IDENTIFIED -NO CAPSULAR INVASION OR EXTRACAPSULAR EXTENSION IDENTIFIED
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index 0000000000000000000000000000000000000000..91f0653bd572f5fb5af7ee2f7fe1ffd662850f0d
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+
+--- Page 1 ---
+Results GROSS AND MICROSCOPIC SURGICAL PANEI Specimen Information Component Results SURGICAL PANEL: LAB: Phone: Fax: Final Report DIAGNOSIS KIDNEY, LEFT PARTIAL NEPHRECTOMY: 1. Renal cell carcinoma, papillary type 1, Fuhrman grade 2 of 4. 2. Tumor is confined to the kidney 3. Tumor focally extends to the inked parenchymal resection margin 4. Negative for lymphatic/vascular invasion by tumor. 5. Please see kidney cancer staging parameters below. COMMENT: The diagnosis was discussed with on at KIDNEY STAGING PARAMETERS*** Case number: Patient name Final TNM: pT1bNXM0 stage:I MACROSCOPIC PROCEDURE Partial nephrectomy SPECIMEN LATERALITY Left TUMOR SITE Not specified TUMOR SIZE 4.3 cm TUMOR FOCALITY Unifocal MACROSCOPIC EXTENT OF TUMOR Tumor limited to kidney MICROSCOPIC HISTOLOGIC TYPE Papillary renal cell carcinoma TUMOR NECROSIS Not identified HISTOLOGICAL GRADE G2: Nuclei slightly irregular, approximately 15 um; nucleoli. evident MICROSCOPIC EXTENT OF TUMOR Tumor limited to kidney LYMPHATIC VASCULAR INVASION Not identified MARGINS Involved by carcinoma Involved margin: Renal parenchymal margin
+
+--- Page 2 ---
+PATHOLOGIC STAGING EXTENT OF INVASION pT1b. (Tumor more than 4 cm but not more than 7 cm in greatest dimension limited to the kidney) REGIONAL LYMPH NODES pNX. (Regional lymph nodes cannot be assessed) DISTANT METASTASIS pMO.(No distant metastasis) PATHOLOGIC STAGE Summary Final TNM: pT1bNXM0 Stage: 1 The pathologic stage presumes no lymph node metastasis. Attending Pathologist: Reviewed by: CLINICAL INFORMATION History of left renal mass SPECIMEN/GROSS DESCRIPTION SOURCE: Left partial kidney nephrectomy The specimen is received fresh from the OR labeled "left partial nephrectomy." It consists of a 49 gram, 4.7 x 4.3 x 4.3 cm rubbery ovoid wedge renal parenchyma. The intact, smooth capsular surface with thin fatty adhesions is inked blue and the predominantly smooth, focally coarse resection margin is inked black. The tissue is serially cross sectioned and the cut surfaces display a 4.3 x 4 x 4 cm tumor bulging the capsule and Iocated less than 0.1 cm from the black inked margin. A representative section of the margin is frozen on one block. INTRAOPERATIVE PATHOLOGY CONSULTATION WITH FROZEN SECTION: "Papillary renal cell carcinoma forming a 4.3 cm greatest dimension tumor, completely excised. Margin is negative for malignancy." is rendered by The cut surfaces of the tumor are yellow, tan, red, variegated and vaguely Iobulated with a thin fibrous capsule. The tumor constitutes at least 90% of the specimen volume. The scant renal parenchyma at the periphery of the margin is grossly unremarkable. Representative sections to include all of the closest black inked renal margin are submitted in nine cassettes as follows: 1 Frozen section residue 2-9. Renal tumor with black inked margin, blue inked capsule and adjacent normal appearing renal parenchyma Note: Representative tissue is banked for possible study. Representative tissue is also apportioned into one vial of RPMl and sent to cytogenetics to hold. This case is accessioned in FileMaker Pro Gross dictation by: MICROSCOPIC The microscopic appearance substantiates the diagnosis. The positive margin is noted on the permanent section. Portions of the specimen not submitted. for frozen section.
+
+--- Page 3 ---
+Dictation by: anscribed by:  Interoreted at COLLECTED ACCESSIONED: SIGNED Lab and Collection GROSS AND MICROSCOPIC SURGICAL PANEL on Lab and Collection Information Result History GROSS AND MICROSCOPIC SURGICAL PANEL on Order Result History Report. Lab Status Order Complete Result Information Result Date and Time Status Provider Status Final result Ordered Lab Information Lab Order Details Parent Order ID Child Order ID Entry Date Specimen Information Specimen Source Collectinn Date Collection Time Other Audit Trail Action Date/Time Order Printed Order Printed MyChart Status: This result is currently not released to MyChart. GROSS AND MICROSCOPIC SURGICAL PANEL Orde Order OrderInformation Date Ordering User Department Authorizing Provider Page 3 of 5
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diff --git a/output/text/2fb4771e-178e-4197-833f-a93561487404.txt b/output/text/2fb4771e-178e-4197-833f-a93561487404.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8899ba0a19c9311216a0e9581e72b0d03c88db72
--- /dev/null
+++ b/output/text/2fb4771e-178e-4197-833f-a93561487404.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+RUN DATE: RUN TIME: SPECIMEN INTERNAL INQUIRY RUN USFR: FOR INTERNAL USE ONLY.  NOT PART OF THE MEDICAL RECORD. PATIENT:  ACCT #: LOC: U # AgE/SX : i/e ROOM: REG DR: Reg: DOb: BED: DIS: STATUS : TLOC: Spec #: RECV: STATUS : REQ #:  Spec: SUEM DR: TYPE : ASSN TO: PT AGE AT RECV: ENTERED: ENT BY: OTHR DR: DEPT: RECV BY: 1cs-0-3 LAST RPTD: WKLD FN: Cautiiomu, mifiltratiny duct, no5 85003 LAST ACT: BAR CD#: SLIDES: Shi, bresst N0S C50.9 3/13/1 ORDERED:  SP IHC STAIN/17 ORD SITE: TRANSIT SITE: RCV SITE: PERFORM SITE : AT SITE: RPT AUDIT: C11 UUID:42DE8E2C-395D-4E98-B78C-6A082F9807CE TCGA-EW-A10Z-01A-PR Redacted STATUS HX: ENT by Grss by DIAG by SOUT by CODES: T04000 - BREAST T04000|m8O001 - bREAST|nEOpLASM, UNcER T04000|M80003 - BREAST|NEOPLASM, MALIg T04000|M85003 - BREAST|INFILTRATING DU TC4000 - LYMPH nODE tC4000|m33150 - Lymph nOde|cOmeDO TC4O00|M55201 - LYMPH NODE|FATTY INFILTRAT TC4000|m67100 - Lymph nOde|PLEOmOrphISm TC4O00|m8O001 - LympH nODE|nEOpLASM, UNCER TC4000|M85003 - LyMPH nODE|INFILTRATING DU TE0120|M8OOO1 - CHROMATIN, NOSINEOPLASM, UNCER Edited by: Continued on next page ...
+
+--- Page 2 ---
+RUN DATE: SPECIMEN INTERNAL INQUIRY RUN TIME: RUN USER: NOT PART OF THE MEDICAL RECORD. FOR INTERNAL USE ONLY. ACCT #: - PATIENT : SPEC #: ICD CODES: 706.1 Edited by: PROCEDURES : SP IHC STAIN Edited by: TISSUES: A. BREAST - LEFT SENTINEL NODE 1 B. BREAST - SENTINEL NODE #2 COUNT# C. BREAST - SENTINEL NODE #3 COUNT BREAST - LEFT BREAST TISSUE ORIENTED WITH SHORT SUPERIOR LONG LATERAL D. Edited by: PRE-OP DX: LEFT BREAST CANCER PROCEDURE : LEFT BREAST MASTECTOMY AND RECONSTRUCTION Edited by: SPECIMEN A IS LABELED SENTINEL LYMPH NODE AND CONSISTS OF A 4.0 X 2.5 X 2.3 CM OVAL,S PINK-TAN LYMPH NODE.  THE CAPSULE IS INTACT. CUT SECTION REVEALS 8O% OF THE LYMPH NODE REPLACED BY FAT. THE RIM IS LIGHT BROWN-TAN WITH NO GROSS EVIDENCE OF TUMOR. MOST OF THE NODE IS SUBMITTED FOR FROZEN SECTION. SCRAPE PREP DONE. SPECIMEN B IS LABELED SENTINEL LYMPH NODE #2 AND CONSISTS OF AN OVAL PIECE OF FIBROFATTY WITHIN THE FAT, THERE ARE TWO OVAL, FIRM, TISSUE MEASURING 2.O CM IN GREATEST DIMENSION. PINK-TAN LYMPH NODES, EACH MEASURING 8.O MM IN GREATEST DIMENSION. SUBMITTED IN TOTO EOR Frozen SecTIoN. SPECIMEN C IS LABELED SENTINEL LYMPH NODE #3 AND CONSISTS OF A 2.O CM PIECE OF PINK-YEILOW, FIBROFATTY TISSUE. WITHIN THE FAT IS A 1.O CM, YELLOW-TAN, FATTY-APPEARING LYMPH NODE. LYMPH NODE IS SUBMITTED IN TOTO FOR FROZEN SECTION. SPECIMEN D IS LABELED LEFT BREAST TISSUE AND CONSISTS OF 137O GRAMS LEFT MASTECTOMY WITHOUT CM AXILLARY DISSECTION (24 X 23 X 6.6 CM) WITH BROWN-TAN SKIN (18 X 11.S CM), AREOLA (4.0 ON THE IN DIAMETER), NIPPLE (1.O X O.5 CM). BOTH AREOLA AND NIPPLE ARE UNREMARKABLE.S SURFACE OF THE SKIN, THERE ARE TWO BROWN-TAN SLIGHTLY ELEVATED, ROUND, WELL-CIRCUMSCRIBED LESIONS LOCATED AT UPPER OUTER QUADRANT (O.2 CM IN GREATEST DIMENSION) AND UPPER INNER QUADRANT (O.4 CM IN GREATEST DIMENSION). THE DEEP SURGICAL RESECTION MARGIN IS INKED Continued on next page ...
+
+--- Page 3 ---
+RUN DATE: RUN TIME: PAGE 3 PTH SPECIMEN INTERNAL INQUIRY RUN USER: FOR INTERNAL USE ONLY.  NOT PART OF THE MEDICAL RECORD. Spec #: PATIENT:  ACCT #: (Continued) BLACK. CROSS SECTIONS REVEAL A ILL-DEFINED, WHITE-TAN, FIRM, GRITTY MASS (3.5 X 3.5 X 2.0 CM), MULTIFOCAL WITH CALCIFICATIONS IN THE UPPER OUTER QUADRANT, LOCATED AT 5.S CM OF|THE DEEP RESECTION MARGIN, LESS THAN O.1 CM FROM THE SUPERIOR RESECTION MARGIN, 6.O CM FRGM THE LATERAL MARGIN, 11 CM FROM THE MEDIAL RESECTION MARGIN AND 7.O CM FROM THE INFERIORS RESECTION MARGIN. STROMAL FAT RATIO IS 20:80.  - SUPERIOR RESECTION MARGIN  THE SPECIMEN IS SUBMITTED AS FOLLOWS: 2 INFERIOR RESECTION MARGIN 3  - MEDIAL RESECTION MARGIN - LATERAL RESECTION MARGIN ANTERIOR RESECTION MARGIN (NIPPLE) 6 - DEEP RESECTION MARGIN 7-8 - REPRESENTATIVE SECTIONS FROM THE TUMOR 9-1O - COMPOSITE SECTION FROM THE TUMOR 11-12 - INTERVENING PARENCHYMA 13-20 - REPRESENTATIVE SECTIONS FROM MULTIFOCAL TUMORAL LESION 21 - REPRESENTATIVE SECTIONS FROM THE LESION DESCRIBED Dictated by: I m.D. Edited by: A. SENTINEL LYMPH NODE LARGE LYMPH NODE WITH EXTENSIVE FATTY INFILTRATION, NGATIVE FOR TUMOR. SENTINEL LYMPH NODE IS NEGATIVE FOR MICROMETASTASIS BY IHC. B.  SENTINEL NODE  NEGATIVE FOR TUMOR. SENTINEL LYMPH NODE IS NEGATIVE FOR MICROMETASTASIS BY IHC. C. SENTINEL NODE #3 COUNT  NEGATIVE FOR TUMOR. LYMPH NODE IS NEGATIVE FOR MICROMETASTASIS BY IHC. D. BREAST, LEFT) MULTIFOCAL HIGH-GRADE INFILTRATING DUCTAL CARCINOMA. MARGINS ARE NEGATIVE FOR TUMOR. SEE BREAST CANCER STAGING BELOW. TUMOR IS STRONLY POSITIVE FOR ER/PR AND HER-2 NEU (3+ TO 4+). CONSIDER HER-2 BY FISH TEST TO CONFIRM AMPLIFICATION. CASE SUMMARY SPECIMEN TYPE: MASTECTOMY: LYMPH NODE: SENTINEL LYMPH NODE(S) ONLY LATERALITY: LEFT TUMOR SITE: UPPER OUTER QUADRANT SIZE OF INVASE COMPONENT: GREATEST DIMENSION: 3.5 CM Continued on next page
+
+--- Page 4 ---
+PAGE RUN DATE: PTH SPECIMEN INTERNAL INQUIRY RUN TIME: RUN USER:  NOT PART OF THE MEDICAL RECORD. FOR INTERNAL USE ONLY. ACCT # PATIENT:  SPEC #: (Continued)  DUCTAL CARCINOMA IN SITU HIGH GRADE COMEDO TYPE HISTOLOGIC TYPE: TWO (2) ONE (1) INVASIVE DUCTAL CARCINOMA. TUBULE FORMATION: MINIMAL LESS THAN 1O% (SCORE=3) NUCLEAR PLEOMORPHISM: MARKED VARIATION INSIZE, NUCLEOLI, CHROMATIN CLUMPING, ETC (SCORE=3) COUNT (FOR THOSE USING NOTTINGHAM SYSTEM) : 10 TO 2O MITOSES PER 1O HPF (SCOREF3) MITOTIC TOTAL NOTTINGHAM SCORE: GRADE III:8-9 POINTS PRIMARY TUMOR (pT): pT2: TUMOR MORE THAN 2.O CM BUT NOT MORE THAN 5.O IN GREATEST DIMENSION REGIONAL LYMPH NODES (pN) : pNO(i-): NO REGIONAL LYMPH NODE METASTASIS HISTOLOGICALLY, NEGATIVE MORPHOLOGIC (ANY MORPHOLOGIC TECHNIQUE, INCLUDING HEMATOXYLIN-EOSIN AND IMMUNOHISTOCHEMISTRY) FINDINGS FOR ITCs. SPECIFY:NUMBER EXAMINED: 4 NUMBER INVOLVED: 0 DISTANT METASTASIS (pM): pMX: CANNOT BE ASSESSED MARGINS: MARGINS UNIVOLVED BY INVASIVE CARCINOMA DISTANT FROM CLOSEST MARGIN: 1 MM, SUPERIOR LATERALS VENOUS: INDETERMINATE MICROCALCIFICATIONS: PRESENT DCIS Dictated by: M.D. Edited by: SENTINEL LYMPH NODE:   LARGE LYMPH NODE WITH EXTENSIVE FATTY INFILTRATION, NEGATIVE JOR A. TUMOR. B. SENTINEL LYMPH NODE #2: LYMPH NODE NEGATIVE FOR TUMOR. SENTINEL LYMPH NODE #3: LYMPH NODE NEGATIVE FOR TUMOR. C. M.D. Dictated by: Edited by: > by M.D. Final: ACTION ENTERED BY DAT TYPE ESIG ADD/PARC SEC SIGN OUT AUDIT DATE NEW M.d. FINAL *** End of Report **
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diff --git a/output/text/2febf19c-4ae4-41fc-9417-9f01937b3b61.txt b/output/text/2febf19c-4ae4-41fc-9417-9f01937b3b61.txt
new file mode 100644
index 0000000000000000000000000000000000000000..95a6ec3419b5be749ede71584ff94c4a19db58db
--- /dev/null
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+
+--- Page 1 ---
+Patient ID: Surgical Date: Gross Description: A. "Fat over mass." A 6.5 x 5.5 x 2.0 cm aggregate of unremarkable fatty fragments. B. "Left kidney ." A 186 gram, 13.5 x 7.5 x 3.1 cm kidney with previously stripped perinephric fat and capsule. The renal artery, vein and ureter at the margin are unremarkable. A well circumscribed slightly necrotic 3.5 x 2.5 x 2.5 cm mass in the lower pole is grossly confined within the kidney. No extension into the small amount of perinephric fat is identified. The remainder of the kidney to include the renal pelvis is grossly unremarkable. A separate 6.5 x 4.5 cm aggregate of perinephric fat is received and is unremarkable. Microscopic Description: Procedure type: Radical nephrectomy Histologic grade (Fuhrman): Mostly grade 2, focally (10-20%) grade 3. Sarcomatoid features: Absent. IcD-o-3 Tumor size: 3.5 cm Carcentine,papllsry renaQ eeQl 8Qed|3 Extent: Limited to kidney. Site Budneey NOS Adrenal Gland:  Not present in specimen. C64.4 Angiolymphatic invasion: Absent. AS/d5/13 Margins: All margins free of tumor Fat over mass (A): Benign adipose tissue. UUID:F8C9C91D-6AED-43EF-BC8F-0481A311706B TCGA-F9-A7VF-01A-PR Redacted Lymph nodes: None present Pathologic stage: pT1a Nx Mx Non-neoplastic kidney: Atherosclerosis, mild glomerulosclerosis and scarring Focal papillary adenoma (1 mm) away from tumor mass, Immunostains were previously performed on the biopsy and consistent with a papillary RCc. Neoplasm has relatively higher Fuhrman nuclear grade. than typical papillary renal cell carcinoma (probably grade 3), however morphology is compatible..  Immunostains for cytokeratin 7, pancytokeratin, p504S and PAx-8 were performed and all four stainse are positive. This is consistent with a papillary-type renal cell carcinoma. Diagnosis Details: KIDNEY (LEFT, B): RENAL CELL CARCINOMA, PAPILLARY TYPE (TYPE I) Comments: Formatted Path Reports: KIDNEY TISSUE CHECKLIST Specimen type: Nephrectomy
+
+--- Page 2 ---
+Tumor site: Kidney. Tumor size: 3.5 x 2.5 x 2.5 cm Focality: Not specified Histologic type: Papillary renal cell carcinoma Histologic grade: Not specified. Tumor extent: Limited to kidney. Lymph nodes: Not specified. Lymphatic invasion: Absent. Venous invasion: Absent Margins: Uninvolvedn Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified. Comments: Left w 9[24|13
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diff --git a/output/text/2ffa0b3f-fe40-4b1e-98a7-5f7a982eab5a.txt b/output/text/2ffa0b3f-fe40-4b1e-98a7-5f7a982eab5a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b08c89e9375896138c56091222d5774ece74928a
--- /dev/null
+++ b/output/text/2ffa0b3f-fe40-4b1e-98a7-5f7a982eab5a.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:FD496AFB-43EF-41D8-850F-E57DD53C185C TCGA-OL-A5D8-01A-PR Redacted  Sample tcd-o-3 Carcino ma, Int, 1tratiny Duct FINAL PATHOLOGIC DIAGNOSIS Nos Mastectomy and sentinel lymph node biopsy, 8500/3 A. Left axillary sentinel node #1: Site: Rth; Breas+ at 6:oD - Single lymph node, no tumor (0/1). C50.8 B. Left axillary sentinel node #2: CgCF Breos+,NoS - Single lymph node, no tumor (0/1). Cso.9 C. Mastectomy, left breast: J12)24112 - Invasive ductal carcinoma, SRB grade II, with focal necrosis - Ductal carcinoma in situ, high nuclear grade, solid type. - Focal Paget' s disease of the nipple. - Uninvolved breast parenchyma with focal flat epithelial atypia, columnar cell change, ductal hyperplasia of usual type, intraductal papilloma. D. Left axillary base, non-sentinel lymph node:. - Two lymph nodes, no tumor (0/2). Breast Pathologic Parameters 1. Invasive carcinoma: A. Size: Gross measurement: 6.5cm B. Composite histologic (modified SBR) grade II - Architecture: 3 - Nuclear grade: 2 - Mitotic count: 1 C. Associated ductal carcinoma in situ (DCIS): - High nuclear grade, solid type. - Associated with (forming 5% of tumor volume) and extending away (focal to involved lactiferous ducts and nipple) from index lesion 2. Excisional biopsy margins: Free of tumor. - DCIS >1cm from deep (closest) margin - Invasive carcinoma 5mm from deep (closest) margin 3. Blood vessel and lymphatic invasion: - Rare microscopic foci worrisome for lymphatic involvement in breast parenchyma. 4. Axillary lymph nodes: Negative for tumor (0/4) 5. Special studies (see) - Strong expression of ER in 100% of invasive tumor nuclei - Strong expression of PR in 100% of invasive tumor nuclei - Her2/neu antigen (FISH): pending on prior biopsy material. 6. pTNM: pT3, N0(sn), MX.
+
+--- Page 2 ---
+Clinical History:. The patient is a.  -year-old female with palpable left breast mass. Biopsy at outside hospital showed invasive ductal carcinoma, ER/PR positive, HER-2 showed left inferior irregular margin. negative. Breast MRI on with irregular mass and heterogenous enhancement at 6 o' clock position. Multiple contiguous satellite lesions are present predominantly extending anterior from the mass. Overall dimensions are 6.4 x 6.1 x 4.1 cm. The right breast was normal. Bilateral axillae were normal.. Specimens Received:. A: Left axillary sentinel node. B: Left axillary sentinel noden. C: Left breast D: Non-Sentinel node base of axilla. Gross Description:. The specimen is received in four containers each labeled with the patient' s name and medical record number. A. Container A is further identified as, 3left axillary sentinel node4. Received fresh is a 2.5 x 1.5 x 1.0 cm apparent lymph node with blue ink. The specimen is bisected and entirely submitted for frozen section with the. diagnosis of 3no evidence of tumor4 per . The frozen remnant is entirely submitted in cassette A1FS. B. Container B is further identified as, 3left axillary sentinel node4. Received fresh is a 2.0 x 1.5 x 1.0 cm apparent lymph node with blue ink. The specimen is bisected and entirely submitted for frozen section with a diagnosis of 3no evidence of tumor4 per .The remnant of the frozen section is. entirely submitted in cassette B1FS C. Container C is further identified as, 3left breast4. Received fresh and placed in formalin is a specimen mastectomy weighing 1100 grams measuring 23.8 cm from medial to lateral, 17.4 cm from superior to inferior, 6.0 cm from  anterior to posterior. The specimen is oriented with two short sutures designated as superior and two long sutures designated as lateral. The breast is overlaid with 14.5 x 10.5 cm adipose and skin. Eccentricallylocated is a 5.8 x 5.2 cm areola with a nipple with a diameter of 1.5 cm. The nipple areolar complex displays no evidence of ulceration or retraction. The deep fascia is inked black and the specimen is sectioned from medial to lateral into ten
+
+--- Page 3 ---
+slices, with the medial slice designated as slice 1. The nipple is located in slice 4 and slice 5. A 6.5 x 4.9 x 3.3 cm mass is located in slice 4 through. slice 7. The mass is white and firm and inferior to the nipple. The margin of the mass is irregular especially at the anterior aspect. A satellite lesion is identified superior and anterior to the index mass located in slice 5 measuring. 1.5 x 1.1 x 1.1 cm and is 0.4 cm from the nearest skin. The mass is 1.0 cm from the closest inked margin on slice 5. A 2.0 x 2.0 x 1.5 cm black discolored area is identified in slice 3 and 4 and another 4.0 x 3.8 x 2.0 cm blue discolored. area is identified on slice 5 and 6. The remainder of the breast consists approximately 17% of adipose tissue and 30% of breast duct parenchyma. Additional masses or nodules are not grossly identified. Representative sections are submitted as follows: C1: nipple C2-C3: areola C4-C7: full section of the tumor on slice 5 with cassette 4 showing the closest deep margin and cassette 6 showing the satellite lesion and the closest skin. C8: section from slice 5 showing satellite lesion and the closest skin C9: representative sections from the tumor on slice 6 C10: inner upper quadrant slice 3 C11: inner upper quadrant slice 4 C12: inner lower quadrant slice 3 C13: inner lower quadrant slice 2 C14: outer upper quadrant slice 5 C15: outer upper quadrant slice 8 C16: outer lower quadrant slice 8 D. Container D is further identified, as 3non-sentinel node base of axilla left4. Received fresh and placed in formalin are two apparent lymph nodes measuring 1.8 x 1.0 x 0.6 cm and 1.2 x 0.7 x 0.5 cm. The specimen is entirely submitted in cassettes D1-D2 with one lymph node in each cassette bisected.. Intraoperative Consult Diagnosis: A1FS. Left axillary sentinel node: No evidence of tumor. B1Fs. Left axillary sentinel node: No evidence of tumor.
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diff --git a/output/text/30084dcb-43fe-4171-81dd-dfeaa9995923.txt b/output/text/30084dcb-43fe-4171-81dd-dfeaa9995923.txt
new file mode 100644
index 0000000000000000000000000000000000000000..304e7435ab26df7cd853f90ca221afa36655fed4
--- /dev/null
+++ b/output/text/30084dcb-43fe-4171-81dd-dfeaa9995923.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:6DCA5C2C-F28A-409D-9623-24AB748FB4E7 1c- 0 -3 TCGA-A8-A08G-01A-PR Redacted Cerciiomn, lnfiItratry ohucttl,N0s 850of3 S.te. brsot, Nus C50.9 Diagnosis: 1 Ablated breast sample with three foci of carcinoma: first tumor: poorly differentiated invasive ductal carcinoma (tumor diameter: 2.8 cm) with focal intraductal components. Tumor-free dorsal resection margin. Tumor classification: NOS and mucinous carcinoma, G IIl, pT2(mult)N0LOV0RX
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diff --git a/output/text/301e7638-74ca-49cd-9c4e-b0f375f3d407.txt b/output/text/301e7638-74ca-49cd-9c4e-b0f375f3d407.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6c0d05e55b19c3f42347e3b06d8867e55120ac49
--- /dev/null
+++ b/output/text/301e7638-74ca-49cd-9c4e-b0f375f3d407.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+FINAL DIAGNOSIS: BREAST. RIGHT, MODIFIED RADICAL MASTECTOMY AND AXILLARY DISSECTION -- A.  INFILTRATINg MAMmARY CARCiNOMA (A, B, C, D, E, F, G and n). THe INVASiVE TUMOR COMES TO WITHIN LeSs ThAn 1.0 mm FROm THe Upper INner DEeP RESECTIOn mARGIn (E) AnD iS ABOUt 1.0 mm AWAY FROM THE JUNCTION OF UPPER INNER AND UPPER OUTER DEEP RESECTION MARGIN (D) (see comment). B. THE TUMOR SIZE IS 4.3 x 3.2 x 2.2 CM. C. NOTTINGHAm SCORE: 6/9 (TUBULES - 3, NUCLEI -- 2, MITOSIS - 1). D. LYMPHOVASCULAR INVASiON IS NOT APPRECIATED. MARGINS OF RESECTION ARE FREE OF TUMOR. F. NIPPLE, WITH TUMOR INVOLVING DEEP DERMIS (A). G. SKIN WITH SEBORRHEIC KERATOSIS, NO TUMOR IS SEEN. H. CHANGES CONSISTENT WITH THE PREVIOUS CORE BIOPSY SITE, SEE PRIOR I. ATYPICAL DUCTAL EPITHELIAL HYPERPLASIA.S J. FIBROCYSTIC CHANGES WITH DUCT ECTASIA AND DUCTAL EPITHELIAL HYPERPLASIA. K. MEDIAL CALCIFICATION OF BLOOD VESSELS. L. METASTATIC ADENOCARCINOMA INVOLVING TWO (2) (W AND AA, BB) OUT OF SEVENTEEN (17) RIGHT AXILLARY LYMPH NODES, UP TO 6.0 CM WITH EXTRACAPSULAR EXTENSION, UP TO 4.0 CM (AA AND BB) (see comment). M. IMMUnOHISTOCHeMICAL STAINInG fOR ESTROgeN RECEPTOR, PrOgESTERONE RECEpTOR, AnD hER- 2/neU WERE PREVIOUSLY PERFORMED ON  AnD WERE REPORTED AS FOLLOWS: ESTROGEN REcEpTOR - pOSITIVE, pROgESterONe RECEpTOR -- NEgAtIVe, AnD hER-2/neu -- NEgATIVe (SCORE: 0). CASE SYNOPSIS: 1gs-0-3 SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST CQCF: Curcinvmk,cuc$l, Nos 850o13 LATERALITY: Right Pon- Cavcikonu nfitnnHng duchl al. PROCEDURE: Modified radical mastectomy LOCATION: 1stu/av 852/3 Upper outer quadrant Iitu> bust,Nos C5U.9 Upper inner quadrant Lower outer quadrant 3/1/n Not specified SIZE OF TUMOR: Maximum dimension invasive component: 43 mm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: No TUMOR TYPE (invasive component): Ductal.adenocarcinoma, NOs, Infiltrating lobular carcinoma, Other Type(s):  Predominently lobular-90% with focal 10% ductal. HIStOLOgIC Type: Classical, Alveolar NOTTInghAm SCOrE: Nuclear grade: 2 Tubule formation: 3 Mitotic activity score: 1 Total Nottingham score: 6 Nottingham grade (1, 2, 3): 2 ANGIOLYMPHATIC INVASION: No DERMAL LYMPHATIC INVASION: No CALCIFICATION: Yes, benign zones SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No PAGET'S DISEASE OF NIPPLE: No LyMPH nODES POSITIVE: 2 LYMPH NODES EXAMINED: 17 METHOD(S) OF LymPh NODE EXAmInATION: H/E stain SIZE OF NODAL METASTASES: Diameter of largest lymph node metastasis: 60.0 mm LYMPH NODE METASTASIS(-ES) WITH EXTRACAPSULAR EXTENSION: Yes, Maximum size is:40.0mm  NON-NEOPLASTIC BREAST TISSUE: ADH, FCD T Stage, Pathologic: pT2 N Stage, PAthoLOgIC: pN1  UUID:575F2EFD-2D8B-4140-9FCB-D8CB9EC14D09 TCGA-Bh-A0hK-01A-PR Redacted M STAGE: Not applicable ESTROGen RECePTORS:  positive PROGESTERONE RECEPTORS: negative HER2/NEU: 0
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diff --git a/output/text/302ced57-f743-44a9-ac6a-dad5e2109ba5.txt b/output/text/302ced57-f743-44a9-ac6a-dad5e2109ba5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..aab7df6dabe8a5929825356a0910ed9f0fd2c21d
--- /dev/null
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+
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+TCGA-AL-3467 SURGICAL PATHOLOGY REPORT Clinical History/Diagnosis: Left Renal Mass. Source of Specimen(s): Left Kidney Gross Description: Received in one part. Source of Tissue: 1. Labeled # 1, "left kidney'. Gross Description: Received fresh in a container with patient's name and medical record number labeled "left kidney". It consists of a 300 gram left radical nephrectomy measuring 12.5 x 6.5 x 4.5 cm. There is a moderate amount of perinephric fat measuring up to 2.0 cm from point of attachment. In the inferior pole there is a bosselated bulging tumor however the capsule is intact. There is no fat overlying the tumor. At the renal hilum there is a 4.0 cm segment of ureter measuring 0.5 cm in diameter. The ureter has a pinpoint lumen with no suspicious lesions or masses. The vascular pedicle is also grossly unremarkable. No adrenal gland or lymph nodes are identified. The kidney is bivalved revealing a tan, soft homogeneous tumor in the inferior pole corresponding to the aforementioned bulging palpable mass. The tumor measures 4.8 x 4.0 x 4.0 cm and grossly appears to invade into the inferior calyx [B]. Elsewhere the usual dark red kidney is present with no additional lesions or masses found. Representative sections are submitted in 1A-H. Fresh tissue is procured for Cytogenetics. Designation of Sections: 1A- ureter and vascular margins, 1B-1C- tumor in relationship to capsule, 1D-1E- tumor, 1F- tumor in relationship to adjacent parenchyma, 1G- fat/potential lymph nodes, 1H- uninvolved kidney ****************************************************** Final Diagnosis: Left kidney: 1 Papillary renal cell darcinoma. /The 4.8 cm-low-grade carcinoma is confined to renal parenchyma Angiolymphatic invasion is not identified.. - Surgical resection margins are free of tumor. pTNM: T1b Nx Mx Comment: Immunohistochemical studies reveal tumor cells positive for CK7
+
+--- Page 2 ---
+and negative for EMA. These results support the light microscopic impression. Procedures/Addenda FC Cytogenetics Solid Results-Comments CYTOGENETIC ANALYSIS REPORTS DIAGNOSIS: Left Renal Mass KARYOTYPE: Normal karyotype: 46,XX[21] RESULTS: The renal mass was harvested after seven days in culture. The chromosomes from 21 metaphases were counted and analyzed, and three of these metaphases were karyotyped by G-banding. The modal chromosome number was 46, and the cells appeared to have a normal karyotype. These normal results may reflect an overgrowth of normal interstitial tissue rather than tumor.
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diff --git a/output/text/3044124d-ad38-4fa3-ba55-0a78cd242815.txt b/output/text/3044124d-ad38-4fa3-ba55-0a78cd242815.txt
new file mode 100644
index 0000000000000000000000000000000000000000..88067c720b9b400bbc40533c8a601ab780869d2b
--- /dev/null
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+
+--- Page 1 ---
+UUID:967CCAA8-5BC6-4744-BD9A-3DFEF9EF4F27 TCGA-E2-A576-01A-PR Redacted Date of Surgery: SPECIMEN(S): A. EXCISIONAL BIOPSY LEFT BREAST NEEDLE LOCALIZED B. SLN #1 LEFT AXILLA 1cD-0 -3 C. SLN #2 LEFT AXILLA Chncinemo, mifilputmy 1cbuliw, nrs 8530j3 Sip: buut, nws c5s.9 hw uf3s|1> CLINICAL HISTORY: Left breast infiltrating lobular carcinoma with Nottingham grade 2; LCIS with. comedonecrosis at the 2:00 position. Ultrasound revealed 12 mm x 15 mm 9 mm lesion.. INTRAOPERATIVE CONSULTATION DIAGNOSIS: A-excisional biopsy left breast needle localized: Lesion identified 0.5 cm (gross) from superior margin. Diagnosis called by Dr. to Dr. DIAGNOSIS: A. BREAST, LEFT, NEEDLE LOCALIZATION WIDE LOCAL EXCISION: - MULTIFOCAL INVASIVE LOBULAR CARCINOMA, NOTTINGHAM GRADE 2. - 1.7 CM AND 0.1 CM IN SIZE. - DUCTAL CARCINOMA IN SITU (DCIS), MICROPAPILLARY TYPE, NUCLEAR GRADE 2, WITH MICROCALCIFICATIONS, MINOR COMPONENT. - LOBULAR CARCINOMA IN SITU (LCIS), PLEOMORPHIC AND CLASSIC TYPES. - MARGINS, NEGATIVE FOR INVASIVE CARCINOMA, DCIS, AND PLEOMORPHIC LCIS. - VESSELS WITH MICROCALCIFICATIONS. NOTE: The size of the tumor (1.7 cm) was determined by measuring the tumor in slides A4 and A5. A 0.1 cm non-contiguous focus of invasive carcinoma was also seen in slide A12. B. SENTINEL LYMPH NODE 1, LEFT AXILLA, BIOPSY: - FOUR LYMPH NODES, NEGATIVE FOR CARCINOMA (0/4) C. SENTINEL LYMPH NODE 2, LEFT AXILLA, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR CARCINOMA (O/1). SYNOPTIC REPORT - BREAST Specimen Type: Excision Needle Localization: Yes Laterality: Left Invasive Tumor: Present Multifocality: Yes
+
+--- Page 2 ---
+WHO CLASSIFICATION  Invasive lobular carcinoma 8520/3 Tumor size: 1.7cm 2:00 Tumor Site: Margins: Negative Distance from closest margin: 0.8cm superior Tubular Score: 3 Nuclear Grade: 3 Mitotic Score: Modified Scarff Bloom Richardson Grade: 2 Necrosis: Absent Vascular/Lymphatic Invasion:  None identified Lobular neoplasia: LCIS Lymph nodes: Sentinel lymph node Lymph node status: Negative 0/5 DCIS present Margins uninvolved by DCIS : 0.7 cm from the posterior margin DCIS Quantity: Estimate 3% DCIS Type:  Micropapillary DCIS Location: Separate from invasive tumor mass DCIS Size (pure DCIS only): 0.3cm Nuclear grade: Intermediate Necrosis: Absent Location of CA++: DCIS Benign epithelium ER/PR/HER2 Results ER: Positive PR: Positive HER2: Negative by FISH Performed on Case: Pathological staging (pTN): pT lc N 0 Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition. SUMMARY OF IMMUNOHISTOCHEMISTRY/SPECIAL STAINS Material: Block A3 Population: Tumor Cells Result: Comment: Stain/Marker: ECADHERIN Negative The interpretation of the above inmunohistochemistry stain or stains is guided by published results in the medical literature, provided.  package information from the manufacturer and by internal review of staining performance and assay validation within the. lmmunohistochemistry Laboratory of the 'e use of one or more reagents in the above tests is regulated as an analyte specific reagent (ASR). These tests were developed and their performance characteristic determined by the Department of Pathology Laboratory at They have not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary.. Special stains and/or immunohistochemical stains were performed with appropriately stained positive and/or negative controls.
+
+--- Page 3 ---
+GROSS DESCRIPTION: A. EXCISIONAL BIOPSY LEFT BREAST NEEDLE LOCALIZED Received fresh labeled with the patient's identification and "excisional biopsy left breast. needle localized" is a previously inked, oriented (single stitch-anterior, double stitch- lateral, triple stitch-superior) 54 g, 3.1 x 3 x 2.9 cm needle localized excision with radiographs. Ink code: Anterior-yellow, posterior-black, medial-green, lateral-right, superior-blue, inferior-orange. The specimen is serially sectioned from lateral to medial into 7 slices revealing a 1.5 x 1.4 x 1.2 cm firm tan stellate mass that is closest to the superior margin at 0.5 cm and a biopsy clip in slice 3. Tissue is procured; representatively submitted as per the attached diagram (time placed in formalin): A1: perpendicular sections of lateral margin A2: slice 2, mid section A3: slice 3, anterior superior with mass A4: slice 4, anterior superior with mass A5: slice 4, posterior superior with mass A6: slice 4, anterior inferior A7: slice 4, mid inferior A8: slice 4, posterior inferior A9: slice 5, mid superior A10: slice 5, posterior superior A11: slice 5, mid section A12: slice 5, mid inferior A13: slice 6, anterior superior A14: slice 6, anterior inferior A15: perpendicular sections of medial margin B. SLN #1 LEFT AXILLA Received fresh labeled with patient's identification and "SLN #1 left axilla" is a piece of yellow-tan soft tissue, 6.2 x 3.1 x 1.2 cm containing 4 lymph nodes ranging from 0.4 x 0.3 x 0.2 cm to 1 x 0.7 x 0.6 cm. The lymph nodes are sectioned and submitted entirely. and separately in B1-B4. C. SLN #2 LEFT AXILLA Received fresh labeled with the patient's identification and "SLN #2 left axilla" is a 1.5 x 0.9 x 0.7 cm lymph node. It is sectioned and submitted entirely in C1
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diff --git a/output/text/3045e3df-9c08-4737-885c-36fd6fb54b74.txt b/output/text/3045e3df-9c08-4737-885c-36fd6fb54b74.txt
new file mode 100644
index 0000000000000000000000000000000000000000..59efea8a90918226f8a3ece0d34683e2b9273c23
--- /dev/null
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+
+--- Page 1 ---
+Pathology Report for. Date of Surgery: IcD o-3 Diagnosis: Cutrocytimo, qpusle I Left temporal brain tumor 0 940t! 3 Anaplastic astrocytoma, grade 3 Cacm Site 7 Rraun, nuyatateus Nos P53: focally positive. C 7i.d IDH1: Negative MIB-1 LI: 13.3% O'Brai, , tinyoras Sshe C71.z Qw 9/a7ll 3 Discussion: The neoplastic cells are negative for IDH1 with a minority expressing p53. MIB-1 reactivity areas are seen within the tumor but in the most proliferative areas a labeling index of 13.3% is calculated, consistent with a high grade astrocytoma. Microscopic Description: Sections demonstrate a diffusely infiltrative astrocytic neoplasm. Atypia ranges from mild to moderate. There is mild to moderate hypercellularity. The tumor cells resemble fibrillary astrocytes. Some areas are suggestive, but not definitive, for perinuclear halos.. A careful examination only reveals a rare mitotic figure. There is no microvascular. proliferation or necrosis. UUID:436222D6-7870-4C4A-8F3A-50562E9AB8A3 TCGA-HT-A74H-01A-PR Redacted
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diff --git a/output/text/30582dca-dee4-4160-8938-c3e38b8047e9.txt b/output/text/30582dca-dee4-4160-8938-c3e38b8047e9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d42ce44f7e90d81f6893517ef570e89fd33b0c92
--- /dev/null
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+
+--- Page 1 ---
+Type: Surgical Patholoqy COLON,   SEGMENTAL RESECT FOR TUMOR Pathology Report Accessioned On: DIAGNOSIS: SIGMOID COLON, SEGME INVASIVE ADENOCARCINOMA of the colon(3.5 x 2.5 x 0.6 cm) pOOrly differentiated,, invading into the subserosa. Margins of resection are negative for tumor. Tumor is 0.1 cm from radial margin. METASTATIC ADENOCARCINOMA in 3 of 20 1ymph nodes. Tumor deposits present in serosa. The AJcc classification is T3 N1 Mx. CLINICAL DATA: History: None given. Operation: Sigmoid resection clinical Diagnosis: Rectal ca TISSUE SUBMITTED: 1. GROSS DESCRIPTION: The specimen is received fresh, labeled with the patient's name, unit number, and "sigmoid colon", is a segment of colon (12 cm in length x 3 cm in diameter) with one stapled resection margin (3.5 cm) and one open end. There is an ulcerated mass with raised, serpiginous borders (3.5 x 2.5 x 0.6 cm) located 3 cm from the opened end and 9.5 cm from the stapled resection margin. The tumor. extends into the muscularis propria, grossly. No extension through to the serosal surface is identified.. The radial margin is O.l cm. The remainder of Representative sections are submitted. the colon segment is unremarkable. _fxags, Micro 1: Tumor to open resection margin, perpendicular Stapled resection margin, en face, 2 frags, Micro 2: Micro 3-4: Full thickness of tumor to areas of deepest invasion and closest radial margin, 3 frags,. Tumor to proxima and distal mucosa, 2 frags, Micro  5: Micro 6: Uninvolved sigmoid, 3 frags, frags. Micro 7 : Potential lymph nodes subjacent to tumor, Micro 8-11: Lymph nodes, 20 frags,. SPECIMEN TYPE: COLON,  SEGMENTAL RESECT FOR TUMOR Page: I o1
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diff --git a/output/text/3062bca1-1989-423b-90c8-c000335a6922.txt b/output/text/3062bca1-1989-423b-90c8-c000335a6922.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2a66c7178026758b17662ab18e7c2cfe77f9875c
--- /dev/null
+++ b/output/text/3062bca1-1989-423b-90c8-c000335a6922.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+UUID:2D9DFA52-DFC5-4F50-9r TCGA-B9-A44B-01A-PR Redacted SURGICAL PATHOLOGY Case Number : 1cD-o-3 Diagnosis: rna) c<11 carc;noma,pap; 1kry A: Left kidney, resection 82003 Histologic tumor type/subtype: Papillary renal cell carcinoma,. 8-Z3-!2 type 2 Sarcomatoid features: Not identified Histologic grade (if applicable): Fuhrman Grade 3 of 4. Tumor size (greatest dimension): 12 cm Tumor focality: Unifocal Extent of tumor invasion (if present specify if macroscopic or microscopic): Capsular invasion: Involved by tumor (microscopic). Perirenal adipose tissue: Not involved Gerota' s'fascia: Not involved Renal sinus: Involved by tumor (macroscopic) Major veins (renal vein or segmental branches, : Involved by tumor (macro and microscopic) Ureter: Involved by tumor (macro and microscopic) Venous (large vessel): Involved by tumor, extensive Lymphatic (small vessel): Involved by tumor Histologic assessment of surgical margins: Gerota' s fascia (nephrectomy): Negative for malignancy. Renal vein (nephrectomy): Positive for tumor Renal artery (nephrectomy: Negative for malignancy Ureter (nephrectomy): Negative for malignancy Adrenal gland: Negative for malignancy Lymph nodes: Not received Other significant findings: Perineural invasion with involvement of ganglion (Al) Renal cortical adenoma, 1 mm in greatest dimension (A11) AJCC Staging: pT3b pNX This staging information is based on information available at
+
+--- Page 2 ---
+the time of this report, and is subject to change pending clinical review and additional information. B: Tumor thrombus, resection - Papillary renal cell carcinoma, type 2. C: Right renal vein margin, biopsy - Positive for papillary renal cell carcinoma, type 2 Clinical History: with a left renal mass. year-old Gross Description: Received are three appropriately labeled containers. Container A: Specimen fixation: formalin Type of specimen: radical nephrectomy. Side of specimen: left Size and weight of specimen: 25 cm x 14 cm x 9 cm, 1,395 grams Orientation: The external perinephric fat is inked blue. Presence/absence of adrenal gland: present. Tumor site: involves the majority of the kidney (upper and lower poles, cortex and medulla) Tumor description: yellow, soft, hemorrhagic, multifocal, sharp borders Tumor size: 12 cm x 9 cm x 9 cm Presence/absence of multicentricity: absent. Confinement/non-confinement to the kidney: appears confined Extent of invasion: Perirenal adipose tissue: tumor does not grossly involve
+
+--- Page 3 ---
+Gerota' s fascia: not grossly involved. Renal vein: suspicious for involvement, grossly there is a large soft mass protruding through the lumen of the vein, clot versus tumor Ureter: suspicious for involvement. Renal Sinus: involved Pelvicaliceal: involved Adrenal: does not grossly involve Other organs: not present Surgical margins:s Perirenal adipose tissue: negative, widely free Renal vein: potentially involved, tumor approaches within 0.5 cm of margin. Renal artery: negative, tumor within 1 cm of margin Ureter: negative, tumor within 0.6 cm of margin Description of kidney away from tumor: tan, cystic in some areas Hilar lymph nodes: none identified. Other significant findings: There is a potential clot located in the renal vein (clot versus tumor).. Tissue submitted for special investigations: tumor Digital picture: not taken Block summary:. Al - renal vein with clot versus tumor (non-marginal) A2 - renal artery, renal vein, ureter margins, en face A3,A4 - ureter suspicious for tumor involvement (non-marginal) A5 - sections of renal capsule, suspicious for tumor (non- marginal) A6,A7 - tumor (non-marginal) A8 - tumor at pelvis
+
+--- Page 4 ---
+A9,A10 - blue inked perinephric fat margins (not grossly involved) Al1 - remnant of more normal appearing kidney A12 - representative sections of uninvolved adrenal gland Container B is additionally labeled "tumor thrombus." It holds a gray/black soft tissue fragment measuring 1.0 x 0.5 x 0.5 cm. (Block B1, Container c is additionally labeled "right renal vein margin." It holds a fragment of renal vein measuring 1.8 x 1.2 x 1.0 cm. Staples are removed. The fragment is sectioned and placed into b1ock C1,
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diff --git a/output/text/3073d949-ce5a-4c58-bc75-473d27313220.txt b/output/text/3073d949-ce5a-4c58-bc75-473d27313220.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a3c3375902b7e83d89e20c2ea3a588604a28ca35
--- /dev/null
+++ b/output/text/3073d949-ce5a-4c58-bc75-473d27313220.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+*** Diagnosis/Diagnoses: *** Right hemicolectomy specimen with an ulcerated colon carcinoma of the histological type of a moderately differentiated colorectal adenocarcinoma, measuring 6.5 cm in its largest diameter, localized 10 cm aborally from the ileocolic valve and almost encircling the intestinal wall. Invasive tumor spread into all intestinal wall layers as far as the adjacent fat tissue and to the level of the subserosa.. Oral and aboral resection margins, greater omentum and appendix tumor-free. Appendix with evidently postinflammatory parietal fibrosis. Tumor stage therefore: pT3, RO; G2 A follow-up report will be made on the lymph node status after special preservation and preparation. *** Follow-up report: **** Forty-four lymph nodes of up to 1.2 cm in size in the vicinity of the tumor were dissected out from the pericolic fatty tissue after clarification with acetone. Microscopically these were all tumor-free. In conclusion or in summary, therefore, a stage of pT3 pN0 (0/44) L0 V0 R0 is established.
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diff --git a/output/text/30a67c8d-4982-4957-84b7-dde9e6dbbdf8.txt b/output/text/30a67c8d-4982-4957-84b7-dde9e6dbbdf8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..de838250664e23c93b70b73081e26b38b096ba37
--- /dev/null
+++ b/output/text/30a67c8d-4982-4957-84b7-dde9e6dbbdf8.txt
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+
+--- Page 1 ---
+UUID:D738C31B-26D6-4868-ABFE-01E6FE6A4F55 Redacted Sample t. 10/13 Gender: Male DOB: Race: Report Date: Pathology Report: /cs-0 -3 carcinona hrcthelixl,Nv5 $1aojj3 Surgical Pathology Report Pnmh Site: blastv,N0s Ct7.9 FINAL PATHOLOGIC DIAGNOSIS CQlF b1cddw,wll psstrior C 61.4 A. Pelvic lymph nodes, right, dissection:. lw 1/3/2 - Twelve lymph nodes, no evidence of tumor (0/12).. B. Pelvic lymph nodes, left; dissection:. - Eight lymph nodes, no evidence of tumor (0/8). C. Prostate and bladder; radical cystectomy: - Invasive urothelial carcinoma; see pathologic parameters below. - Prostatic adenocarcinoma; see pathologic parameters below. - Sixty-five lymph nodes, no evidence of tumor. Urothelial Carcinoma Pathologic Parameters 1. Tumor type: Urothelial carcinoma.. 2. Grade of tumor: High-grade. 3. Depth of invasion: Muscularis propria, outer half.. 4. Tumor distribution: Solitary, 6.3 x 5.1 x 5.0 cm (depth); posterior wall. 5. Ureteral Margins: Negative. 6. Distal urethral margin: Negative. 7. Lymph nodes: No carcinoma in 85 regional lymph nodes (0/85). 8. pTNM: pT2b, N0, MX. Radical Prostatectomy Pathologic Parameters. 1. Gleason Score: 3+4 = 7/10. 2. Perineural Invasion: Absent. 3. Tumor Location: Peripheral zone right. 4. Tumor Volume Estimate: <5%. 5. High-grade P.I.N.: Multifocal. 6. Seminal Vesicles: Negative for tumor. 7. Fibromuscular Capsule: Tumor confined to the prostate. 8. Peripheral Margin: Positive for tumor (C16) 9. Distal (apical) Margin: Negative for tumor. 10. Proximal (basilar) Margin: Negative for tumor. 11. Regional Lymph Nodes (right and left): Negative for tumor. 12. pTNM: pT2a, N0, MX. xxx
+
+--- Page 2 ---
+[] m.D. Interpretation performed by the Attending Pathologist and reviewed with the Resident or Fellow. Electronically Signed Out by [] M.D.. Clinical History: The patient is a  -year-old male with a history of bladder tumor. Bladder washing showed urothelial carcinoma. The patient underwent radical cystectomy and neobladder. Specimens Received: A: Right pelvic lymph node B: Left pelvic lymph node C: Prostate & bladder Gross Description: The specimen is received in three containers each labeled with the patient's name and medical record number. A. Container A is further designated 31. right pelvic lymph node4. Received fresh and placed in formalin are fragments of yellow-brown lobulated adipose tissue measuring 8.5 x 6 x 1.2 cm aggregate. Multiple firm rubbery lymph node candidates are dissected from the specimen ranging from 0.2-5.5 cm in greatest dimension. Representative sections are submitted as follows:. A1-A3:  multiple lymph node candidates A4-A6: one matted lymph node candidate B. Container B is further designated 32. left pelvic lymph node4. Received fresh and placed in formalin are multiple fragments of yellow-brown adipose tissue measuring 6.5 x 5.5 x 2.0 cm in aggregate. Multiple yellow-brown firm-rubbery lymph node candidates are dissected from the specimen ranging from. 0.2-4.0 cm in greatest dimension. Representative sections are submitted as follows: B1-B3:  multiple lymph node candidates B4.B5:  one matted lymph node candidate, bisected C. Container C is further designated 33. bladder and prostate4. Received fresh and placed in formalin is a specimen of cystectomy weighing 395 gm and the overall measurement is 14.5 x 10.5 x 6.0 cm. The bladder measures 9.0 x 8.5 x 5.5 cm and the prostate measures 4.0 x 3.3 x 3.0 cm. The bladder is opened from the anterior wall with a Y-shaped incision. A gray-white, firm, ulcerated mass is identified in the posterior wall of the bladder measuring 6.3 x 5.1 cm and raised 2.8 cm from the bladder mucosa. Multiple small papillae are identified in the periphery of the mass. The outer surface of the bladder and the prostate is inked black on the left side and blue on the right side. Probing through the ureters reveals that both ureteral orifices are involved by the tumor. The specimen is serially sectioned. Both ureters are surrounded by solid tumor. The tumor displays a thickness of 5.0 cm. The tumor grossly invades through the bladder wall but not through the surrounding adipose tissue. The center of the tumor is white and soft and grossly necrotic. The prostate and the seminal vesicles are not grossly invaded by tumor. No lymph nodes are identified in the peri-bladder adipose tissue. Received in the same container is a 4.8 cm round tubular tissue with a diameter of 0.4 cm. Representative sections are submitted
+
+--- Page 3 ---
+as follows: C1:  urethral margin C2:  ureter margin C3,C4: sections through the right ureter C5,C6:  sections through the left ureter C7,C8:  representative sections of tumor showing deepest invasion C9-C11: representative sections of the tumor C12: normal bladder and sections of the detached tubular structure C13-C27:the entire prostate C28:  Seminal vesicles C29, C30: representative sections of tumor xxx [] M.D. PhD
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diff --git a/output/text/30ce7c16-a84c-4f0c-88f4-88f7ee2369ab.txt b/output/text/30ce7c16-a84c-4f0c-88f4-88f7ee2369ab.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ebb2584db491f5c3f308792777a1286fcd793f33
--- /dev/null
+++ b/output/text/30ce7c16-a84c-4f0c-88f4-88f7ee2369ab.txt
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+
+--- Page 1 ---
+Clinical Diagnosis & History: Large right renal mass. Specimens Submitted 1:SPRight kidney and part of right adrenal DIAGNOSIS: 1) KIDNEY AND ADRENAL,RIGHT,NEPHRECTOMY AND PARTIAL ADRENALECTOMY: -RENAL CELL CARCINOMA,CHROMOPHOBE TYPE.THE PATTERN OF GROWTH IS ACINAR AND SOLID.THE TUMOR GREATEST DIAMETER IS 10.9CM. THE TUMOR IS CONFINED WITHIN THE RENAL CAPSULE. THE TUMOR EXTENDS INTO THE RENAL PELVIS AND INVADES THE RENAL VEIN WITH TUMOR THROMBOEMBOLUS.ALL SURGICAL MARGINS ARE FREE OF TUMOR.THE NON-NEOPLASTIC KIDNEY IS UNREMARKABLE.THE ADRENAL GLAND SHOWS CORTICAL NODULAR HYPERPLASIA. THE COLLOIDAL IRON STAIN IS NON-CONTRIBUTORY. IATTEST THAT THE ABOVE DIAGNOSIS IS BASEDUPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL).AND THAT I HAVE REVIEWEDAND APPROVED THIS REPORT Gross Description: 1) The specimen is received fresh, labeled "Right kidney and part of right adrenal". It consists of nephrectomy specimen including kidney, attached perinephric fatty tissue and portion of adrenal, measuring 16.5 x 11.8 x 6.6 cm overall and weighing 770 grams. The attached portion of adrenal measures 5 x0.8 x 0.5 cm. Also attached to the kidney is a segment of ureter, measuring 7.5 cm in length by 0.4 cm in diameter.Present at the middle portion slightly towards to the upper pole and on the lateral aspect is a bosselated, slightly lobulated tumor mass, measuring 10.9x 9.9 x 5.4 cm. On cut surface, the mass shows purple-pink-tan lobulated, soft periphery with foci of hemorrhagic necrosis and a central fibrosis. The mass which Page 1 of2
+
+--- Page 2 ---
+SURGICAL PATHOLOGYREPORT involves renal cortex and medulla, is grossly impinging on the pelvis. The renal capsule grossly is not involved by tumor. Examination of the hilar vessels reveal the vascular lumen to be filled by tumor thrombus. The ureteral mucosa grossly is pink- tan and smooth. The uninvolved renal parenchyma is purple-white without additional lesion. Within the hilar area and perinephric fatty tissue, no lymph nodes are identified. Sectioning of adrenal shows yellow-golden granular nodule,1.0 x0.8 x 0.5 cm. Portion of the specimen is submitted for Tps. Summary of Sections: U -urethral margin VM -vascular margin VT -vascular tumor thrombus T -section from tumor P section from pelvis A section from uninvolved area AD -adrenal Histo Stain Results/Comments: Stain/Procedure Name Result Comment COLLOIDAL IRON(MOWRY) COLLOIDAL IRON MOWRY) CONTRO COLLOIDAL IRON (MOWRY)CONTRO Summary of Sections: Part Sect. SiteBlocks Pieces All 1 A 1 1 N AD 1 1 P 1 1 T 4 4 U 1 1 VM 1 2 VT 2 2 hil 1 1 Page2of2 ENDOFREPORT
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diff --git a/output/text/30d7766b-647b-4a14-894e-1b0f69c0006d.txt b/output/text/30d7766b-647b-4a14-894e-1b0f69c0006d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..18b02b79c8ed88604c2c71c20b1adbd1adb77ab8
--- /dev/null
+++ b/output/text/30d7766b-647b-4a14-894e-1b0f69c0006d.txt
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+
+--- Page 1 ---
+1cd-0-3 Carcnoma 10bulw, nfit+nxtmg 85a0|3 Path Srtu cdi : brenst, outer C50,8 Sir'- brust,nts c5o.9 1a|21/10 jw CQCF Final Diagnosis Breast, left, mastectomy: Infiltrating lobular carcinoma, Nottingham grade I (of Ill) (tubules 3/3, nuclei 1/3, mitoses 1/3; Nottingham score 5/9], forming a mass (6.5 x 5.2 x 3.5 cm) located in the superior portion of the breast [AJCC pT3]. Lobular carcinoma in situ (less than 5% of tumor volume) is present. The non-neoplastic breast parenchyma shows nonproliferative fibrocystic changes with duct ectasia. Calcifications are present in benign ducts and acini. The tumor does not involve the nipple, overlying skin, or underlying chest wall. All surgical margins, including the deep margin, are negative for tumor (minimum tumor free margin, 0.8 cm, deep margin). A single (of 6) lymph node is positive for metastatic carcinoma [AJCC pN1]. Lymph node, left axillary, sentinel No. 1, excision: A single left axillary sentinel lymph node is positive for metastatic carcinoma. Immunohistochemical cytokeratin stain was performed on the paraffin embedded sentinel lymph node tissue and confirms the H&E impression. Blue dye is not identified. Lymph node, left axillary sentinel No. 2, excision: A single left axillary sentinel lymph node is negative for metastatic carcinoma. Immunohistochemical cytokeratin stain was performed on the paraffin embedded sentinel lymph node tissue and confirms the H&E impression. Blue dye is identified. Lymph node, left axillary, sentinel No. 3, excision: A single left axillary sentinel lymph node is positive for metastatic carcinoma with a single focus measuring 0.9 cm in greatest dimensions. Blue dye is identified. Lymph nodes, left axillary, dissection: Multiple (6) axillary lymph nodes are negative for. metastatic carcinoma [AJCC pN1]. Estrogen and progesterone receptor analysis and Her-2/NEU have been ordered on paraffin. embedded tissue. Seen in consultation with Dr.. UUID:E3044C68-4497-4212-8CA1-AC944434CC54 TCGA-AR-A1AL-01A-PR Redacted
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diff --git a/output/text/30f0de11-cb1d-4335-a1e4-6c2ccde8be01.txt b/output/text/30f0de11-cb1d-4335-a1e4-6c2ccde8be01.txt
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+IaDO 3 NoS 8070/3 Document Type: Anat Path Reports Document Date: C6CF Document Status: UUID:2286118E-FACB-407E-8F84-2D6EF71C10E9 Sute TCGA-QK-A6V9-01A-PR Redacted Orphauyuy NoS Document Title: @i09 Performed By: Verified By: oot. `ylatire.trnoI Encounter info: C09.9 * Final Report *  8/2|13 (Verified) Patient Name: Acc #: MRN: DOB: Location: Gender: M Collected: Client: Received: Submitting Phys: Reported: Copy To Phys: Final Surgical Pathology Report *** ADDENDUm PRESENT *** Addendum Diagnosis The diagnosis is unchanged. See comment. Addendum Comment Tumor shows strong dot-like nuclear signal for HPV 16/18 by in situ hybridization.. Electronirallu Signed by. Assisted by: Final Pathologic Diagnosis A. TonsIL, Right, tonsillectomy, A1fs-A4fS: - SQUAmOUS CELL CARCINOMA, MODERATELY DIFFERENTIATED, 3.5 CM IN MAXIMUm GROSS DIMENSION. - Detached fragment Of CArcinOma Present At The inferiOr mucOSal EDge (See SEPARATELY SusmItted margin Specimen belOw). - REMAINING MUCOSAL AND DEEP MARGINS FREE OF INVASIVE CARCINOMA OR HIGH GRADE DYSPLASIA. - NO ANGIOLYMPHATIC OR PERINEURAL INVASION IDENTIFIED.S - See synoptic report And comment. B. TONSIL, RIGHT FINAL INFERIOR MARGIN, EXCISION:E  - NEGATIVE FOR HIGH GRADE DYSPLASIA OR INVASIVE CARCINOMA.E Comment
+
+--- Page 2 ---
+An immunoperoxidase stain for p16 is strongly positive. In situ hybridization for HPV is pending. Electronicallv Signed by Assisted by: Addendum / Signed Out Synoptic Worksheet A. Right radical tonsillectomy: Oropharynx Specimen: Received: Fresh Procedure: Resection, Tonsillectomy Specimen Integrity: Fragmented Specimen Size: Greatest dimension: 5.0 cm Additional dimension: 4.5 cm Additional dimension: 3.5 cm Specimen Laterality: Right Tumor Site: Oropharynx, Palatine tonsil Tumor Laterality: Right Tumor Focality: Single focus Tumor Size: Greatest dimension: 3.5 cm Additional dimension: 1.9 cm Additional dimension: 1.4 cm Histologic Type: Squamous cell carcinoma, conventional Histologic Grade: G2: Moderately differentiated Margins: Margins uninvolved by invasive carcinoma Distance from closest margin: 0.4 Unit of measurement: cm Margin(s): Superior mucosal margin Margins uninvolved by carcinoma in situ (includes moderate and severe dysplasia) Lymph-Vascular Invasion: Not identified Perineural Invasion:. Not identified Lymph Nodes, Extranodal Extension:. Not identified Pathologic Staging (pTNM): TNM Descriptors: Not applicable Primary Tumor (pT): Oropharynx: pT2: Tumor more than 2 cm but not more than 4 cm in greatest dimension Regional Lymph Nodes (pN): Oropharynx: pNX: Cannot be assessed Number of regional lymph nodes examined: 0. Number of regional lymph nodes involved: 0. Additional Pathologic Findings: None identified Ancillary Studies: Human papillomavirus associated carcinoma Other: P16 positive. HPV ISH pending. Clinical History. Tonsil cancer. Specimen(s) Received A: Right radical tonsillectomy B: Final inferior margin; ink true margin..
+
+--- Page 3 ---
+Gross Description. Specimen A is received fresh for intraoperative consultation, labeled with the patient's name, medical record number and as "right radical tonsillectomy." The specimen consists of a radical tonsillectomy specimen measuring 5.0 x 4.5 x 3.5 cm. Upon receipt in Pathology, the specimen is fragmented into two distinct fragments. The specimen is oriented by the surgeon,. He specifies each mucosal margin, which are submitted for frozen section consultation. Arising within the palatine tonsil there is a large polypoid mass measuring 3.5 x 1.9 in surface  dimension by a depth of 1.4 cm. The mass is the following distance from each respective mucosal margin: superior 0.4 mm, medial 0.5 cm, inferior 1.0 cm and lateral 2.3 cm. The mass comes within 0.5 cm of the deep resection margin. The mucosal margins are inked as follows: superior, blue; medial, black; lateral, yellow, inferior, orange. The deep margin is inked green. A portion of the tumor is submitted for research purposes. Representative sections are submitted as described in the cassette summary. (Dictated by. Specimen B is received fresh and labeled with the patient's name, medical record number and as "final inferior margin; ink true margin". Received is a small piece of mucosal lined fibrous tissue measuring 1.2 x 0.9 x 0.4 cm with ink on one side. No discrete lesions are identified. The marked surface is re-ink blue and the specimen is serially. sectioned and entirely submitted in cassette "B1." (Dictated by. CASSETTE SUMMARY: A1FS: Lateral mucosal margin, shave A2FS:  Inferior mucosal margin, shave A3FS: Superior mucosal margin, shave A4FS:  Medial mucosal margin, shave A5: Tumor with respect to medial resection edge and deep margin A6:  Tumor with respect to medial resection edge and deep margin A7: Tumor with respect to superior resection edge and deep margin A8: Additional representative mass with respect to deep margin A9: Lateral resection edge (yellow) with respect to deep margin. A10,11:  Inferior resection edge (orange) with respect to deep margin Intraoperative Consult Diagnosis A1fS: LATERAL MARGIN (FROZEN SECTION): NEGATIVE FOR CARCINOMA. A2FS:  INFERIOR MARGIN (FROZEN SECTION): RARE DETACHED FOCUS OF CARCINOMA A3FS:  SUPERIOR MARGIN (FROZEN SECTION): NEGATIVE FOR CARCINOMA. A4FS:  MEDIAL MARGIN (FROZEN SECTION): NEGATIVE FOR CARCINOMA. Frozen section results were communicated to the surgical team and were repeated back by. on Pathologist: Microscopic Description Microscopic examination performed. ANALYTE SPECIFIC REAGENT (ASR) DISCLAIMER: Some of the above tests may use Class I ASRs. These tests were developed and their performance characteristics determined by They have not been cleared or approved by the Federal Drug Administration (FDA). The FDA does not require these tests to go through premarket FDA review. These tests are used for clinical purposes and should not be regarded as investigational or for research.. is  certified under the Clinical Laboratory Improvement Amendments (CLIA) as qualified to perform high complexity clinical laboratory testing..
+
+--- Page 4 ---
+7/22/13
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index 0000000000000000000000000000000000000000..8addf8f13e77f40ee8b77aed52ff2ce5ea781955
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+UUID:A6D9B05F-99EE-4E2F-9321-277EC714A514 TCGA-WN-A9G9-01A-PR Redacted SURGICAL PATHOLOGY REPORT NAME: SURG PATH #: MR #: SPECIMEN CLASS: BILLING #: ALT ID #: LOCATION: DATE OF PROCEDURE: AGE: SEX: M DATE RECEIVED: DOB: TIME RECEIVED: PHYSICIAN: DATE OF REPORT: COPY TO: DATE OF PRINTING: Ied0 3 Material Received: snoma, papillary rersL eeQL.8xb43 A: renal mass left - stitch deep margin. B: peri tumor fat N6S C64.9 Sidney History: J 9/13/14  year-old male with history of a renal mass. Final Diagnosis: A. Kidney, "left renal mass", partial nephrectomy: Renal cell carcinoma, papillary type, Fuhrman grade 3. See comment. B.Fibroadipose tissue, "peri tumor fat", biopsy: There is no evidence of malignancy.. Comment: Specimen Type: Partial nephrectomy. Laterality: Left Tumor Site: Upper pole Focality:  Unifocal Tumor Size: 5.5 x 4.5 x 3.9 cm Histologic Type: Papillary renal cell carcinoma, type 2 Histologic(Fuhrman) Grade: Grade 3 Macroscopic Extent of Tumor: Tumor is confined to the kidney  Surgical Margins: Margins uninvolved by invasive carcinoma Adrenal Gland: N/A Large vessel invasion (renal vein, vena cava): N/A Microvascular invasion: Not identified. Lymph Nodes: N/A Pathologic Staging: pT1b NX  Renal Cell Carcinoma  Primary Tumor (pT) pT1b: Tumor more than 4 cm but not more than 7 cm in greatest dimension, limited to the kidney Regional Lymph Nodes (pN). pNX: Cannot be assessed Distant Metastasis (pM) MR #: Page 1 of 2 Date of Printing: SURGICAL PATHOLOGY REPORT Order Number:
+
+--- Page 2 ---
+NAME: SURG PATH #: MR #: ALT ID #: pMX: Cannot be assessed The pathologic stage assigned here should be regarded as provisional, as it reflects only current pathologic data and does not  incorporate full knowledge of the patient's clinical status and/or prior pathology. Pursuant to the this case has been concurrently reviewed by the following pathologist: who agrees with the above diagnosis. Attestation: By this signature, I attest that I have personally formulated the final interpretation expressed in this report and that the above diagnosis is based  upon my examination of the slides and/or other material indicated in this report. ***Electronically Signed Out By*** Interpreted by: Gross Description: A.Received fresh labeled with the patient's name and "renal mass" is a 5.5 x 4.5 x 4.2 cm partial nephrectomy specimen.The margin is designated by a suture. The margin is inked black and the capsule is inked blue. The specimen is serially sectioned to reveal a 5.5 x 4.5 x 3.9 cm encapsulated yellow gold mass that is adjacent to the margin but not extending through the margin grossly. The mass is also adjacent to the blue capsule. The uninvolved kidney is tan-brown, pale and unremarkable. A representative section of the mass to the margin is submitted in cassette A1FS for frozen and permanent sections. Additional representative sections are submitted in cassettes A2-A7. B. Received in formalin labeled with the patient's name and "peritumor fat" are multiple tan-pink irregular unoriented tissue fragments. No discrete mass is identified grossly. The specimen is submitted entirely in cassettes B1-B3. Intraoperative Consultation: A1FS, kidney, "renal mass": Margins free of involvement. Renal cell carcinoma, favor papillary type/ 343 MR #: Page 2 of 2 Date of Printing: SURGICAL PATHOLOGY REPORT
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+ICD-0-3 Cardiomn, lnfil+nratwg duchl avel 1obulw 8SxQf3 Push Site: Brast uog c50.4 CQcF Site: Bust nos C50.9 Diagnosis: 5. Invasive breast carcinoma of mixed differentiation with partly ductal and partly lobular components (max. diameter 1.5 cm, malignancy grade II). No angioinvasion, no coarse calcification. Minimum width of ventral safety margin 0.5 cm. Distant fibrolipomatous parenchyma of the breast and adjacent skin spindle free of atypia.. Tumor classification: pT1c (1.5 cm), pN0 sn (n=4), MX, R0; G2 (L0, V0) UUID: BD2AE048-BE93-4421-AD3E-BE6F9646484F3 Redacted TCGA-A8-A0AD-01A-PR
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index 0000000000000000000000000000000000000000..9e17789ab64523cc3846d9c0fb617e54511050d1
--- /dev/null
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+
+--- Page 1 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: FMP/SSN: Specimen #: DOB/Age/Sex: Race: BLACK Location: Taken: Physician(s) : Received: Reported: Jcs-0-3 SPECIMEN: A: LEFT BREAST QUADRANTECTOMY B: LEVEL #1 & #2 AXILLARY LYMPH NODES 3ife. breast Nos C50.9 1/25/ h FINAL DIAGNOSIS: A. BREAST, LEFT, QUADRANTECTOMY:  MODERATELY DIFFERENTIATED (GRADE II) INFILTRATING DUCTAL CARCINOMA.S * NOTTINGHAM SCORE: 7 OUT OF 9 (TUBULES=3, NUCLEI=2, MITOSES=2). * MAXIMUM TUMOR SIZE: 3.0 CM (MEASURED GROSSLY). * VENOUS/LYMPHATIC INVASION: PRESENT (E.G., SLIDES A3 AND A4). * MARGINS: NEGATIVE. : TUMOR PRESENT O.27 CM FROM THE ANTERIOR (BLUE) INKED) TISSUE EDGE (SLIDE A1). INTRADUCTAL COMPONENT: PRESENT. DUCTAL CARCINOMA IN SITU, INTERMEDIATE NUCLEAR GRADE (DCIS, GRADE II); SOLID TYPE WITH FOCAL INTRALUMINAL NECROSIS AND MICROCALCIFICATIONS.  LYMPH NODES: 1 OF 23 LYMPH NODES POSITIVE FOR METASTATIC CARCINOMA (1/23; PLEASE SEE PART "B")  ESTROGEN RECEPTORS: POSITIVE (>95% NUCLEAR STAINING; PLEASE SEE) PROGESTERONE RECEPTORS: POSITIVE (60-7O% NUCLEAR STAINING; PLEASE) * SEE * HER 2 NEU BY IHC: 2+ (PLEASE SEE * HER 2 NEU BY FISH: PENDING (PLEASE SEE * PATHOLOGIC STAGE: pT2NIMX.  ADDITIONAL FINDINGS: * PRIOR BIOPSY SITE CHANGES. B. LYMPH NODES, LEFT AXILLA LEVELS 1 AND 2, AXILLARY DISSECTION: ONE OF TWENTY-THREE LYMPH NODES POSITIVE FOR METASTATIC CARCINOMA (1/23). * LARGEST METASTATIC FOCUS: 1.4 CM WITH FOCAL EXTRANODAL EXTENSION (LESS THAN 0.1 CM). UUID:990F5885-8EDD-42A2-AEFE-9DEE3E95A081 TCGA-A2-A0D4-01A-PR Redacted Page 1 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 Continued on Next Page
+
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+FOR OFFICIAL OSX ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: FINAL DIAGNOSIS (continued): Report Electronically Signed Out ** CLINICAL DIAGNOSIS AND HISTORY: yo black female with breast cancer, left inner mid breast g2 (7/9). +lvi, er/pr+, her2/neu 2+, fna+ of left axillary lymph node. Time in formalin: 84 hours. PRE-OPERATIVE DIAGNOSIS: breast cancer POST-OPERATIVE DIAGNOSIS: none provided GROSS DESCRIPTION: A: Received fresh, labeled with the patient's name,. designated "Left Breast Quadrantectomy" is a 408 gm lumpectomy specimen and oriented with a single short black stitch superior, long black lateral, double blue deep, triple blue medial, and anterior margin is inked blue. The specimen measures 19.0 cm superior to inferior, 14.0 cm medial to lateral, and 4.0 cm anterior to posterior. The specimen is inked as follows: anterior-blue, superior-orange, lateral-yellow, medial-red, inferior-green, and deep-black. Serial sections reveal a 3.0 x 2.0 x 1.7 cm well-defined, tan-pink, gritty mass with focal congestion. The mass comes to within 0.5 cm of the closest margin (anterior). On sectioning through the mass a 0.4 cm red-brown biopsy cavity is identified, with~an embedded metallic clip. The remainder of the specimen is predominantly composed of lobulated, yellow-tan adipose tissue admixed with. approximately 20% fibrous tissue. No additional lesions are identified. Representative sections are submitted.. Cassette Summary: A1-A2- anterior margin; A3-A4- mass; A5-A6- mass with cavity; A7- mass; A8- adjacent normal; A9- section with medial (red inked) tissue edge adjacent to sections from A1-A6; A10- adjacent section of medial-posterior (red and black inked) tissue edges; A11-A12- sections of white fibrous area with lateral (yellow inked) tissue edge in plane immediately next to plane of sections A1-Al0; Al3- sections of anterior (blue inked) tissue edge adjacent to tumor area taken from A7; Al4- medial-anterior (red and blue inked) tissue edges taken from area adjacent to A7. **Matched sections of A3, A5-A8 are submitted in OcT for CBcp Protocol* Page 2 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 3 ---
+FOR OFFICIAL USX ONLY - PERSONAL DATA - PRIVACY ACT OF 1974S SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION (continued) : B: Received fresh, labeled with the patient's name,. designated "Level 1 and 2 Axillary Lymph Node" is a 10.0 x 7.5 x 2.0 cm. and irregular portion of soft tissue. Sectioning reveals multiple pink-red to pink-tan lymph nodes ranging in size from 0.7 cm in greatest dimension to. 3.0 x 1.0 x 0.7 cm. Sectioning through the larger lymph nodes reveals a. markedly congested cut surface. The iymph nodes are submitted entirely as follows: Cassette Summary: B1-B2- one lymph node; B3-B4- one lymph node; B5- one lymph node, bisected; B6- one lymph node; B7- four lymph nodes; B8- one. lymph node; B9- one lymph node, bisected; B10- one lymph node, bisected; Bi1- one lymph node; B12- one lymph node, bisected; B13- two lymph nodes bisected (one inked green); B14-21: additional lymph node candidates. **Matched sections of B1, B3,B6,B8 are submitted in ocr for CBcp Protocol. Page 3. End of Report FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974S
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index 0000000000000000000000000000000000000000..9a2a2b46d9a24a4193d5845b331331ec0980b4ae
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+--- Page 1 ---
+UUID:258903DE-CB30-4577-9571-C470256E21C6 TCGA-DK-A3IV-01A-PR Redacted SURGICAL PATHOLOGY REPORT Patient Name: Accession #: Med. Rec. #: Date of Procedure: DOB: (Age: Location: Date of Receipt: Gender: M Service:  Urology Date of Report: Ref. Physician: Account #: Patient Address: Billing Type: OUTPATIENT Additional Copy to: Ref. Source Clinical Diagnosis & History:. Bladder mass Specimens Submitted:. 1: Left lateral and anterior wall bladder tumor DIAGNOSIS: Left lateral and anterior wall bladder tumor: Tumor Type: Invasive urothelial carcinoma, NOs, with focal squamous differentiation Histologic Grade: High grade ics-0-3 Pattern of growth of the non-invasive component: cascincma,nrothelisI Nvs 812cf3 Flat (in situ carcinoma). oatn Sifu: 51addr wnUl nts cL7.9 Local Invasion: CQCF: s1asldr, wll, laterul ei1.7 Muscularis propria fwJ 1/7/11 Vascular Invasion: Not identified I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT i HAVE REVIEWED AND APPROVED THIS REPORT. *** Report Electronically Signed Out **** Gross Description: 1) The specimen is received in Hank's solution, labelled "Left lateral and anterior wall bladder tumor" and consists of multiple  pieces of irregular tan-brown soft tissue fragments measuring 1.3 X 1.1 X 0.6 cm in aggregate. The specimen is entirely submitted in two cassettes. TPS submitted. Summary of Sections:. Part 1:  Left lateral and anterior wall bladder tumor Sect. Site PCs Block 2 {not entered} 12 7a/?/1 Page 1 of 1 END OF REPORT
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index 0000000000000000000000000000000000000000..6df7dd5ea8e8efd60d5fc319e5e7aff75cda8f89
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+--- Page 1 ---
+TcD0-3 arenorieurothhal pyllouy * Final Report 8130l 3 CtLF Sul Modoler N6 S C679! QJ 3l2e|J4 Document Type: UUID:B2C3CDC0-DC42-4971-9203-30B712F89553 *Date - Date of Service:. TCGA-XF-A9SU-01A-PR Redacted Document Status: Document Title: Encounter info: Contributor system: * Final Report * ORDERING PHSYCIAN:E Ordering Physician:. PRE-OPERATIVE DiAGNOSIS: Bladder CA POST-OPERATIVE DIAGNOSIS: Same MICROSCOPIC DESCRIPTION: A-D: See final microscopic-diagnosis.. E: Sections of the bladder show multiple extensive areas of high-grade invasive urothelial carcinoma, penetrating into perivesical fat but sparing adjacent organs. (uterus and cervix). Extensive multifocal lymphovascular space invasion is. present. Also present are several foci of the deceptively bland trabecular pattern. superficially invading the lamina propria.. Sections of the cervix show cervical intraepithelial neoplasia (cin III) with gland duct involvement. No invasive cervical squamous cell carcinoma is. identified. Architecturally while the urethra is involved with urothelial. carcinoma. the ectocervix and cervical stroma are not, thus the two processes are physically discontinuous. Signature Line Signed by: ELECTRONIC SIGNATURE GROSS DESCRIPTION: A:  The specimen is received fresh from the O.R. for rapid frozen analysis and. labeled "Rt. distal ureter". It consists of a segment of ureter measuring 0.6 x 0.5 x 0.2 cm. The specimen is submitted entirely for frozen section.. B: The specimen is received fresh from the O.R. for rapid frozen analysis and. labeled "Lt. distal ureter". It consists of a segment of ureter measuring 0.6 x Printed by: Page 1 of 8 Printed on: (Continued)
+
+--- Page 2 ---
+* Final Report 0.6 x 0.5 cm. One cassette is submitted for frozen section and one cassette is submitted for permanent section. C: The specimen is received fresh from the O.R. for rapid frozen analysis and. labeled "Inter aortal caval upper limits of dissection". It consists of lymph node. measuring 2 x 2 x 0.5 cm. One cassette is submitted for frozen section and one cassette is submitted for permanent section.. D: The specimen is received fresh from the O.R. for rapid frozen analysis and labeled "Apical urethral margin F/s". It consists of section of mucosa measuring 4 x 0.3 x 0.2 cm. The specimen is submitted entirely for frozen section. E: The specimen is received fresh from the O.R. for intraoperative consultation. and labeled "Bladder". It consists of radical cystectomy specimen measuring 11 x 13 x 4.5 cm. The peritoneal surface measures 13 x 8 x 0.1 cm. There is no puckering or erythema. The bladder measures 7 x 7 x 2 cm.  The bladder is opened along its anterior aspect to reveal several ulcerations with overlying pseudo membranes as well as a pedunculated lesion.  The largest ulcer measures 4 x 3 cm and extends grossly into to perivesical fat. A 2.5 x 2 cm ulcer is located A 1.5 x 1 cm ulcer is located in the right aspect of the dome. A 1.5 x 1 cm ulcer is located inferior to the left ureteral orifice and 1 x 0.5 cm ulcer is located at the urethral margin. The pedunculated. lesion measures 2 x 1 cm and is located in the left anterior aspect of the dome of the bladder. The mucosa,  which is uninvolved with ulceration, is inflamed and edematous. The right distal ureter measures 5.5 cm in length and 0.5 cm in circumference. The left distal ureter measures 4 cm in length and 1 cm in circumference and contains a stent. Received in continuity with the specimen is 12. x 8 x 2 cm uterus and adnexa.  The uterine serosa is smooth. The right fallopian tube measures 5.5 cm in length and 0.5 cm in diameter.  The right ovary measures 2 x 1 x 0.5 cm and is grossly unremarkable. The left fallopian tube measures 7.5 cm in length and 0.5 cm in diameter. The left ovary measures 1.5 x 1 x 0.5 cm and is grossly unremarkable. Several small peritubal cysts, which are clear and thin-walled, are noted on the. surface of the left fallopian tube. The ectocervix measures 3.5 cm in greatest diameter. The cervical os measures 0.8 cm and is unremarkable. The uterus is opened to reveal a 3.5 cm endocervical canal lined with mucoid tan epithelium and a 4.5 x 1.5 x 0.1 cm endometrial canal lined by a velvety tan endometrium. The myometrium displays the usual pink-tan trabeculated appearance interrupted by a single myoma located intramurally and measuring 1.2 cm in greatest diameter. There is no hemorrhage or necrosis of the myoma. Representative sections submitted entirely in twenty-five cassettes. F: The specimen is received in formalin and labeled "Right para caval lymph nodes". It consists of a portion of node bearing adipose tissue measuring 3.5 x 2.3 x 2 cm. The specimen is submitted entirely in one cassette. Printed by: Page 2 of 8 Printed on: (Continued)
+
+--- Page 3 ---
+* Final Report * G: The specimen is received in formalin and labeled "Right common iliac nodes". It consists of a portion of node bearing adipose tissue measuring 7 x 3.6 x 1.2 cm. The specimen is submitted entirely in two cassettes. H: The specimen is received in formalin and labeled "Left para aortic lymph nodes". It consists of a portion of node bearing adipose tissue measuring 2.5 x 2 x 1 cm. The specimen is submitted entirely in one cassette..  The specimen is received in formalin and labeled "Left common iliac lymph. I: nodes". It consists of a portion of node bearing adipose tissue measuring 4.3 x 2.3 x 1 cm. The specimen is submitted entirely in one cassette. J:  The specimen is received in formalin and labeled "Right lymph node of cloquet". It consists of a portion of node bearing adipose tissue measuring 2.3 x 1.2 x 1 cm. The specimen is submitted entirely in one cassette.. K: The specimen is received in formalin and labeled "Right external iliac lymph nodes".  It consists of a portion of node bearing adipose tissue measuring 4.5 x 4.2 x 1.5 cm. The specimen is submitted entirely in two cassettes.  The specimen is received in formalin and labeled "Right obturator/hypogastric L: lymph nodes". It consists of a portion of node bearing adipose tissue measuring 5.5 x 4 x 2 cm. The specimen is submitted entirely in three cassettes. M: The specimen is received in formalin and labeled "Left lymph node of cloquet". It consists of a portion of node bearing adipose tissue measuring 2.2 x 1.5 x 1 cm. The specimen is submitted entirely in one cassette.. N:  The specimen is received in formalin and labeled nLeft external iliac lymph nodes". It consists of a portion of node bearing adipose tissue measuring 5 x 3 x The specimen is submitted entirely in one cassette. 1cm.  The specimen is received in formalin and labeled "Left obturator/hypogastric lymph nodes". It consists of a portion of node bearing adipose tissue measuring 5. x 5 x 0.5 cm. The specimen is submitted entirely in three cassettes.. P: The specimen is received in formalin and labeled "Right presciatic lymph. nodes". It consists of a portion of node bearing adipose tissue measuring 1 x 1 x 0.5 cm. The specimen is submitted entirely in one cassette.. Q: The specimen is received in formalin and labeled "presacral lymph nodes". It consists of a portion of node bearing adipose tissue measuring 2 x 1.5 x 1 cm. The specimen is submitted entirely in one cassette. Printed by: Page 3 of 8 Printed on: (Continued)
+
+--- Page 4 ---
+* Final Report R: The specimen is received in formalin and labeled nLeft presciatic lymph nodes".. It consists of a portion of node bearing adipose tissue measuring 1 x i x 0.5 cm. The specimen is submitted entirely in one cassette.. S:  The specimen is received in formalin and labeled "urethra". It consists of a cylindrical tan tissue fragment lined on the inside by mucosa and on the outside by fibrous tissue measuring 3.5 x 2 x 2 cm. A stitch is present indicating the proximal aspect of the specimen. The specimen is radially inked black. Serial sections are submitted entirely in five cassettes.. T:  The specimen is received in formalin and labeled "Left proximal ureter". It consists of section of ureter measuring 2 x 1 x 0.3 cm. The specimen is submitted entirely in one cassette. U: .The specimen is received in formalin and labeled "Right proximal ureter".. It consists of section of ureter measuring 2 x 1 x 0.3 cm.  The specimen is submitted entirely in one cassette. SECTIONS: AFs: frozen section, rt. distal ureter ART: remaining tissue  embedded BFs: frozen section, lt. distal ureter BRT: remaining tissue embedded cFs: inter aortal caval upper limits of dissection embedded. CRT : remaining tissue embedded DFs: frozen section, apical urethral margin F/S E1: right ureter specimen margin E2 : left ureter specimen margin E3 : right ureterovesical junction E4 : left ureterovesical junction E5: trigone, bladder neck E6: ulcer at urethral specimen border E7-8: right posterior large ulcer E9-10: right posterior large ulcer, junction with adjacent urothelium El1: right posterior smaller ulcer E12: pedunculated lesions tip E13-14: pedunculated lesion, remaining E15: dome E16: anterior cervix E17: posterior cervix E18: anterior endo myometrium to serosa with myoma E19: posterior endo myometrium to serosa with myoma. E20 : right adnexa E21: left adnexa E22-23: right perivesical fat Printed by: Page 4 of 8 Printed on: (Continued) 1
+
+--- Page 5 ---
+* Final Report E24-25: left perivesical fat F: right para caval lymph nodes embedded G1-2: right common iliac nodes embedded H: left para aortic lymph nodes embedded I: left common iliac lymph nodes  embedded J: right lymph node of cloquet embedded. K1-2: right external iliac lymph nodes  embedded L1-3: right obturator/hypogastric lymph nodes. embedded M: left lymph node of cloquet embedded N: left external iliac lymph nodes embedded. 01-3: left obturator/hypogastric lymph nodes embedded p: right presciatic lymph nodes embedded Q: presacral lymph nodes embedded. R: left presciatic lymph nodes embedded S1: margin S2-5 : serial sections from distal to proximal. T: left proximal ureter  embedded U: right proximal ureter" INTRAOPERATIVE DIAGNOSIS: GROSS DIAGNOSIS: Bladder (E) : tumor present near urethral margin DIAGNOSIS COMMENT: Carcinoma in situ with pagetoid spread is noted in the cervix (part E) and ureterectomy specimen (part s). We will perform further studies in an attempt to determine if the two processes are related or, are separate, and these results will be reported in an addendum. SEE Addendum - relsted ord y trenstonl ceUl type. FINAL DIAGNOSIS: RADICAL CYSTECTOMY AND HYSTERECTOMY WITH BILATERAL SALPINGO-OOPHORECTOMY: RIGHT DISTAL URETER (A) : FROZEN DIAGNOSIS: NO TUMOR IDENTIFIED FINAL DIAGNOSIS: BENIGN URETER NO DYSPLASIA OR MALIGNANCY IDENTIFIED Printed by: Page 5 of 8 Printed on: (Continued)
+
+--- Page 6 ---
+* Final Report LEFT DISTAL URETER (B) : FROZEN DIAGNOSIS:  NO TUMOR IDENTIFIED FINAL DIAGNOSIS:  BENIGN URETER  SHOWING REACTIVE ATYPIA  NO DYSPLASIA OR MALIGNANCY IDENTIFIEDS INTER AORTAL CAVAL UPPER LIMITS OF DISSECTION (C) :) FROZEN DIAGNOSIS: NO TUMOR IDENTIFIED FINAL DIAGNOSIS:  NO EVIDENCE OF MALIGNANCY IN SIX LYMPH NODES (0/6)) APICAL URETHRAL MARGIN (D) : FROZEN DIAGNOSIS: CARCINOMA IDENTIFIED FINAL DIAGNOSIS: INVASIVE UROTHELIAL CARCINOMA EXTENSIVELY INVOLVING SUBMITTED TISSUE BLADDER, UTERUS, BILATERAL FALLOPIAN TUBES AND OVARIES WITH RIGHT AND LEFT PERIVESICAL LYMPH NODES (D) : BLADDER (D) GROSS DIAGNOSIS: TUMOR ULCER PRESENT AT URETHRAL MARGINS FIANL DIAGNOSIS: : INFILTRATING UROTHELIAL CARCINOMA, HIGH GRADE WITH FOCAL TRABECULAR AND NESTED FEATURES, NUCLEAR GRADE 3-4/4 WITH INVASION THROUGH MUSCULARIS PROPRIA AND GROSSLY INTO PERIVESICAL FAT MULTIFOCAL CARCINOMA IN SITU HIGH GRADE PAPILLARY UROTHELIAL CARCINOMA EXTENSIVE, MULTIFOCAL LYMPHOVASCULAR SPACE INVASION IDENTIFIED TUMOR PREDOMINANTLY INVOLVES THE LEFT POSTERIOR BLADDER WALL URETHRAL MARGIN IS POSITIVE FOR CARCINOMA (SEE PART D) THE FINAL URETHRAL MARGIN IS INVOLVED BY CARCINOMA IN SITU (SEE PART S) INVASIVE TUMOR DOES NOT INVOLVE CERVIX OR UTERUS, HOWEVER, CERVIX SHOWS CARCINOMA IN SITU (SEE COMMENT)) BILATERAL URETER MARGINS ARE NEGATIVE WITH LEFT URETER SHOWINGS SCAR AND REACTIVE ATYPIA SECONDARY TO STENT PLACEMENTS UTERUS, BILATERAL FALLOPIAN TUBES AND OVARIES: CERVIX SHOWING CARCINOMA IN SITU WITH PAGETOID SPREAD ENDOMETRIUM, ATROPHIC ENDOMETRIUM AND MYOMETRIUMS SMALL LEIOMYOMATA Printed by: Page 6 of 8. Printed on:. (Continued)
+
+--- Page 7 ---
+* Final Report SEROSA SHOWING NO SIGNIFICANT PATHOLOGIC CHANGE BILATERAL OVARIES AND FALLOPIAN TUBES SHOWING PHYSIOLOGIC ATROPHY RIGHT AND LEFT PERIVESICAL LYMPH NODES:S  NO LYMPH NODES OR TUMOR IDENTIFIED (O/0) RIGHT PARACAVAL LYMPH NODES (F) :  NO EVIDENCE OF MALIGNANCY IDENTIFIED IN SIX LYMPH NODES (O/6) RIGHT COMMON ILIAC LYMPH NODES (G) :  NO EVIDENCE OF MALIGNANCY IDENTIFIED IN EIGHT LYMPH NODES (O/8) LEFT PARAAORTIC LYMPH NODES (H): NO EVIDENCE OF MALIGNANCY IDENTIFIED IN SEVEN LYMPH NODES (O/7) LEFT COMMON ILIAC LYMPH NODES (I): METASTATIC CARCINOMA IDENTIFIED IN ONE OF FOUR LYMPH NODES (1/4) RIGHT LYMPH NODE OF CLOQUET J):  NO EVIDENCE OF MALIGNANCY IDENTIFIED IN ONE LYMPH NODE (O/1) RIGHT EXTERNAL ILIAC LYMPH NODES (K):) -  NO EVIDENCE OF MALIGNANCY IDENTIFIED IN FIVE LYMPH NODES (O/5) RIGHT OBTURATOR/HYPOGASTRIC LYMPH NODE (L) :  NO EVIDENCE OF MALIGNANCY IDENTIFIED IN SEVEN LYMPH NODES (O/7) LEFT LYMPH NODE OF CLOQUET (M) :  NO EVIDENCE OF MALIGNANCY IDENTIFIED IN FOUR LYMPH NODES (0/4) LEFT EXTERNAL ILIAC LYMPH NODES (N) :  NO EVIDENCE OF MALIGNANCY IDENTIFIED IN ONE OF NINE LYMPH NODES (1/9) LEFT OBTURATOR/HYPOGASTRIC LYMPH NODES (O) :  NO EVIDENCE OF MALIGNANCY IDENTIFIED IN 12 LYMPH NODES (0/12) RIGHT PRESCIATIC LYMPH NODES (P) :  NO EVIDENCE OF MALIGNANCY IDENTIFIED IN TWO LYMPH NODES (O/2) PRESACRAL LYMPH NODES (Q) :  NO EVIDENCE OF MALIGNANCY IDENTIFIED IN 13 LYMPH NODES (0/13) LEFT PRESCIATIC LYMPH NODES (R) : NO EVIDENCE OF MALIGNANCY IDENTIFIED IN TWO LYMPH NODES (O/3) Printed by: Page 7 of 8 Printed on: (Continued)
+
+--- Page 8 ---
+* Final Report URETHRA (S) : EXTENSIVE CARCINOMA IN SITU IDENTIFIED WITH PAGETOID SPREAD CARCINOMA IN SITU INVOLVES DISTAL RESECTION MARGIN RADIAL INKED SURGICAL MARGINS, ARE NEGATIVE (SEE COMMENT) LEFT PROXIMAL URETER (T) : BENIGN URETER NO IN SITU OR INVASIVE CARCINOMA IDENTIFIED RIGHT PROXIMAL URETER (U): BENIGN URETER NO IN SITU OR INVASIVE CARCINOMA IDENTIFIED TNM STAGE: pT3bN1MX LYMPH NODE sUMMARY: Tumor identified in 2 of 87 lymph nodes (2/87) Printed by: Page 8 of 8 Printed on: (End of Report)
+
+--- Page 9 ---
+HISTORY ADDENDUM REPORT * Final Report * Document Type: *Date - Date of Service: Document Status: Document Title: Encounter info: Contributor System: Final Rer DIAGNOSIS: Carcinoma-in-situ with pagetoid spread was noted in the patient' s biadder, urethra, and also in the cervical specimen. In order to determine the origin of these processes, and whether or not they were related or separate,  we performed immunohistochemical studies on the bladder tumor (slide E7), the cervix (slide E17), and the urethra (slide S2). The studies demonstrate the following: E7 E17  S2  Bladder Cervix Urethra CK7 ++ ++ ++ +/- squamous mucosa CK20 + - squamous mucosa CPV High background High background High background These results indicate that the carcinoma in situ process is related, and of transitional cell origin. Thus, the transitional cell carcinoma is extending by pagetoid spread widely throughout the anterior exenteration specimen. 88342 x 9 Signature Line Signed by: ELECTRONIC SIGNATURE Completed Action List: Printed by: Page 1 of 1 Printed on: (End of Report)
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new file mode 100644
index 0000000000000000000000000000000000000000..dd55bea3f51bdd847287c879c36d33e794850e51
--- /dev/null
+++ b/output/text/31871334-a8c4-42c5-9c2b-d64e8cdeaa2c.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+1cD-0-3 Carirms, mfiltrting ductl, Nos 85otf3 Path : Sit: bruast, C 50.8 upper CerF Msst c50.9 Nos IRB APPROVEDS Inical Case Report. (For Collection of Cancerous Tissue) UUID:DD831719-1D2F-4502-B80E-544B684DC16F3 TCGA-C8-A1HE-01A-PR Redacted Informed Consent. I personaly informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the  with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution.. Signature Date Name of Physician or Study Coordinator Clinical Information PSAERAGENERALINEORMATIONS Marital Status. Race Date of Birth (mm/dd/yyy). Height 1.44M  Single Married  Blood Pressure Heart Rate Gender Weight  Divorced  Widow 13s/c8 mm] L s 83 i74  Male Female PTHISTORYOEPRESENTILLNESSTOASWC Chief Complaints:s I`uuowr i tbe 8iqbt bLeaef Symptoms: Pheut Hml n Furmr i, HereqhF hRoogf5^monHy ago Clinical Findings: - He oHlur i. 2x 2g, ju lnrd, nrahle.onullyplurd Performance Scale (Karnofsky Score):  60-70 Symptomatic, in bed less than 50% of day  100 Asymptomatic  80-90 Symptomatic but Fully Ambulatory  20-30 Bed Ridden  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden MERAAS CE SPASTMEDIGALHISTORYERSARATEXEX Treatment Status Diagnosis Datee Diagnosis/Disease/Disorder/Injury hme zastrihe
+
+--- Page 2 ---
+OBGYNHISTORY Menopausal Status Date nf First Menses # of Pregnancies  Pre-menopausal easolf  Peri-Menopausal Date of Last Menses. # of Live Births Post-menopausal year, olf 4 Birth Control:  Condom  Oral Contraceptive  iUD  Hormone Replacement  Other: NO Therapy: SOCIALHISTORY Occupation: Environmental Hazards: Smoking History Current Status TypE  Packs/day Duration When Quit  YES (yrs) (y) Alcohol Consumption Current Status TYPE Drinks/day Duration When Quit  YES YnO (yrs) (yr) Drug Use Current Status TYPE Freguency Duration When Quit YES bNO (yrs) (y CNELOASLNFAMIEYMEDICALHISTORYNASLCS Diagnosis Age of Diagnosis Relative Carile EMEABDATAS Test Result Date Test Result Date  HIV Negative  Positive: CEA  Negative  Positive: CA 15-3  Negative  Positive: Hep B t Negative  Positive: CA 19-9   Negative  Positive: Hep C   Negative  Positive: AFP PSA  Negative  Positive:  Negative  Positive: Other: Other:  Negative  Positive:  Negative  Positive: B/T Cell Markers: EOTETESNDIAGNOSTICSTUDIESSPASEASCRS Date Study Resuits Ultrasound X-Ray CT Endoscopy MRI Biopsy 2
+
+--- Page 3 ---
+SONACCLINICALDIAGNOSISCPE Preoperative Clinical Diagnosis Riglt Kea?  Caswr Location of Suspected Involved Lymph Nodes Location of Suspected Distant Metastasis. Axilla NO Clinical Staging Date of Diagnosis Stage: JLA Treatment Informationd RRNASHNSURGICAETREAIMENTEMAEY Procedure Date of Procedure Daley's Cur} y Primary Tumor Organ Detailed Location Size Baeast upper haly R xd x cm Extension of Tumord No Lymph Nodes Location of Lymph Nodes # of Lymph Nodes Description Palpable, Non-Dissected Lymph Nodes Axilla: Dissected Lymph Nodes Distant Metastasis Organ Detailed Location Size Surgical Staging M o Stage: TA T9 No xNEOADJUVENTTHERAPYChemoRadiation.Immuno,Hormonalor MolecuarKy Route Frequency Date (mm/dd/yyy) Drug/Treatment Dose 1 To / To 100 To MADJUVENTTHERAPY (Chemo,Radiation ImmunoHormonalorMolecular Frequency Date (mm/dd/yyyy). Drug/Treatment Dose  Route To To To SALFCOTHER MEDIGATIONSKSASA Date (mm/dd/yyyy) Dose Route Freguency Drug 1 To 1 To 1 1 To / 1 To / 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by: Date: Time: Preserved by: Date: -Time: SSPECIMENTYPE (#ofsamples providedas Frozen Paraffin Block Blood/$erum/Plasma. Slide Diseased Norma! Diseased Normal Diseased Normal Diseased Normal x Time to LN2 Time to Formalin Time to LN2 min min min k SWPATHOLOGICALDESCRIPTION EYS Primary Tumor Organ Size Extension of Tumor Distance to NAT BBeast Q x L x No 9  cm cm Lymph Nodes Location # Examined # Metastasized Axilla $ Distant Metastasis Organ Detailed Location Size Ne Pathological Staging pT9 No Mo Stage: ICA Notes: 4
+
+--- Page 5 ---
+COnSOLIdATED DIagnOsTIC pAthOLOgy fORm* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION + STRUCTURAL PATTERN Diffuse  Streaming Mosaic Storiform Necrosis X} Fibrosis Lymphocytic Infiltration Vascular Invasion Palisading  Cystic Degeneration Clusterized Bleeding Alveolar Formation Myxoid Change Indian File XPsamoma/Calcification 2. Cellular features. Squamows +. Adcaomatous + Sarcomstous + Lymphomatous  Squamoid Cell Glandular cel! Round Cell Lagre Cell Spindle Cell Cell Stratification Fibroblast Small Cell Keratin Secretion 1 Osteoblast RS CelVRS Lik  Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell Pear! Gland formation Myoblast  Plasma Cell Otherwise Specified: Ds 07: Dr6OZ 2.Cellular Differentiation: Well Moderately Poor Nxclear Atypia: Nuclear Appearance. Aniso Nucleosis Hyperchromatism Nucleolar Prominent Multinoc!cated Giant Cell Mitotic Activity Nuckear Grade Histological Diagnosis:_nh(tRsb2y DUttel (aZi nMsq, o! G~1 Comments: gy ST STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CON
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diff --git a/output/text/319dc9cd-8e8d-4e1c-9fee-44885a17dfc6.txt b/output/text/319dc9cd-8e8d-4e1c-9fee-44885a17dfc6.txt
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index 0000000000000000000000000000000000000000..73cc01deaf5a50a34f83b88bcceb9f5fa5be13f3
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+
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+Internal Sample Diagnosis: This is a moderately to poorly differentiated adenocarcinoma of the colon (G2 to 3) with infiltration of all parietal layers and vascular infiltration (L1, V1) as well as six lymph node conglomerate metastases (6/12, N2) and in II a gall bladder preparation with parts of an adenocarcinoma, possibly to be interpreted as a further spread of the colon cancer described.. in IlI parts of the liver with parts of the carcinoma described.. 1cD-0-3 adenocarcinona Nos 91y0/3 SiHx 0igmod cvLor C18.7 p 3/30f1 UUID: 3BEA7ED1-F6E7-4A2E-9489-744503D3F0E7 TCGA-AA-A02H-01A-PR Redacted
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diff --git a/output/text/31b6eca0-5aa6-468a-b4c2-420e7e758e98.txt b/output/text/31b6eca0-5aa6-468a-b4c2-420e7e758e98.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2c5a9898440f73a66613fba57124a14746552fb5
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+
+--- Page 1 ---
+Histopathology Report Biopsy No: Corrected Received Date/Time Final Reporting Information Date/Time : Final Updated Histopathologist : Laboratory Final Specimen Comment (A1FS) 12 x 10 x 3mm (xl) Consultant-In-Charge. Final Submitting Physician Final Histopathology Report. Final Updated ADDENDUM ADDENDUM TO HISTOPATHOLOGY REPORT One immunohistochemical result had been inadvertently omitted from the original report.. The neoplastic cells are negative for pancytokeratin AEr/3 in the presence of a working. external positive control, excluding thymomas,. carcinomas, carcinoids and non-germinomatous germ. cell tumours in conjunction with the B-lymphoid immunophenotype of the neoplasm.. THE DIAGNOSIS REMAINS UNCHANGED. NOTE : Please see below for original report.. Pathologist DIAGNOSIS (A) ANTERIOR MEDIASTINAL / THYMIC MASS: DIFFUSES LARGE B-CELL LYMPHOMA. (B) PARATRACHEAL LYMPH NODE: REACTIVE HYPERPLASIA. FROZEN SECTION DIAGNOSIS (AFs) Mediastinal mass resection: "Round cell". neoplasm; lymphoma not excluded. Please await. araffin workup GROSS DESCRIPTION (A) Received fresh for frozen section and subsequently fixed in formalin as frozen remnant is a specimen labelled with patient's data and designated "mediastinal mass resection". It consists of a bilobed thymic mass measuring 12 Printed from.
+
+--- Page 2 ---
+x 9 x 6.5cm straddling the tracheal furrow posterosuperiorly, with posteriorly adherent pericardium measuring 7 x 4.5cm sutured on its left edge, as well as an adherent, stapled wedge of right lung measuring 5 x 2 x 1cm. The specimen has been sectioned parallel to the coronal plane to reveal a solid, "fish-flesh" whitish tumour with a slightly lobulated cut surface measuring 10.5 x 8.5 x 6cm with a focal (approximately 10% of the tumour volume), eccentric area of necrosis. The tumour abuts on the resection margin circumferentially and is situated 2cm from the lung parenchymal resection margin. (AlFs, A2 to A10-fixed sections of tumour, A1l & A12-tumour with pericardial surface inked green, Al3 & A14-tumour with circumferential resection margin inked red, A15 & Al6-tumour, Al7-tumour with lung and parenchymal resection nked yellow}, Al8-tumour with surrounding fat) (B) The specimen is received in formalin, labelled with patient's data, and designated "paratracheal lymph node". It consists of a piece of fibrofatty tissue measuring 1.2 x 0.8 x 0.8cm. (B1; no reserve) MICROSCOPIC DESCRIPTION (A) TUMOUR CHARACTERISTICS Type : Diffuse large B-cell lymphoma. Grade : High. Architecture : Vaguely nodular-to-diffuse, patternless sheets with fibrovascular partitioning,. unaccompanied by perivascular spaces. Necrosis : Present focally (especially Blocks A1l, A13, A15 and A16). Cytology : Large lymphoid cells with ample, pale eosinophilic-to-clear cytoplasm and. irregular vesicular nuclei, mostly with a centroblastic nucleolar disposition. Immunophenotype. The lymphomatous cells are diffusely positive for pan-B cell marker cd2o, with intense immunoreactivity the germinal centre-associated transcription modulator bcl-6, but not its associated surface marker cdlo (which highlights mainly circulating granulocytes), accompanied by widespread coexpression of late-to-postgerminal centre-associated transcription factor Mum-l as well as antiapoptosis protein bcl-2, the latter in overt excess over physiological expression by the small numbers of intermingled and interspersed, reactive, small cD3-positive T-lymphocytes (which disclose perivascular accentuation), excluding both precursor lymphoblastic neoplasia in conjunction with the cytoplasmic abundance and presence of a peripheral (rather than precursor. blastic) nuclear chromatin pattern, as well as Burkitt lymphoma in conjunction with a cell proliferation fraction of well below 100% (70-80% on average) by Ki-67 immunolabelling, which also highlights a degree of nuclear pleomorphism that is inappropriate for the latter entity. In this context, variable, patchy coexpression of cp30 is in keeping with a mediastinal/thymic primary, although CD23 coexpression is not forthcoming, with its B-lineage excluding anaplastic lymphoma. In addition, the preferential intensity and extent of bcl-6 over Mum.1 nuclear expression negates classical Hodgkin lymphoma of lymphocyte-depleted morphology. Immunostaining for Cyclin Dl is negative within the lymphomatous. population, highlighting only physiological expression in scattered histiocytic and activated endothelial nuclei, ruling out a transformed mantle cell lymphoma. Despite the nodularity of the infiltrate, cd21 immunostaining is completely negative for any trace of a follicular dendritic meshwork, in the presence of a working external positive control. Proliferation : Mitoses : Easily found.. Tumour edges : Demarcated. Stromal reaction : Compartmentalising sclerosis with a sprinkling of small lymphocytes. EXTENT OF TUMOUR Local invasion : Replaces most of thymus except focally (Block All), and extends into right lung (Block Al7) with adhesion but not penetration of pericardium. Mediastinal lymph nodes (Block A18 and B1) appear uninvolved. (B) Histology shows a lymph node with architectural preservation and Printed from:
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diff --git a/output/text/31e6adb3-94d8-4529-9fdf-4216d8c4d234.txt b/output/text/31e6adb3-94d8-4529-9fdf-4216d8c4d234.txt
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index 0000000000000000000000000000000000000000..0e4cb7b361c7b4916a31e8d6cbe9f707db700181
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+
+--- Page 1 ---
+page 1 / 1 Department of Cancer Pathology original Examination: Histopathological examination Internal invoice No. Cost of diagnostic procedure Examination No.: Patient: XXX PESEL: XXX Age: Gender: Material: 1. Multiple organ resection -- colon Unit in charge: Physician in charge: Material collected Material received on: Expected time of examination:. Clinical diagnosis: right side of the colon along with the transverse, descending and sigmoid colons (two tumours, one stained with blue dye on the right side of the transverse colon, the other one -- tumour of the distal part of the sigmoid colon, polyps? in the splenic flexure) Examination performed on: Macroscopic description: An 82 cm length of the large intestine with periintestinal tissue sized 85 x 9 x 3.5 cm, a 37 cm segment of the small intestine, a 6.5 cm appendix and the omentum sized 30 x 13 x 3 cm . An ulceration sized 2 x 1.9 x 0.3 cm found in the mucosa. The lesion surrounds 20% of the intestine circumference and is located 18.9 cm away from the proximal excision, 6.4 cm from the distal excision line, and 15.8 cm away from the Bauhin's valve. Additionally, tumour sized 2.4 x 2.2 x 0.8 cm surrounding approx. 40% of the circumference located 69.8 cm from the proximal boundary and 8.8 cm from the distal one. The distance between the tumours is 49.3 cm. Microscopic description: Adenocarcinoma tubulopapillare bifocale (G2). Infiltratio carcinomatosa telae adpisae pericolicae. Excision lines clear of neoplastic infiltration. Outside the tumour: Adenoma tubulopapillare cum dysplasia gradus minoris. Lymphonodulitis reactiva (NO V). Histopathological diagnosis Adenocarcinoma tubulopapillare bifocale coli. Tubulopapillar bifocal adenocarcinoma of the colon (G2, Dukes B, Astler - Coller B2, pT3, pNO). Compliance validated by: Examination performed on: Supplementary information Additionally, five reactive lymph nodes found in the collected specimens (pNO). Compliance validated by: CONTACT YOUR DOCTOR WITH THIS REPORT!
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index 0000000000000000000000000000000000000000..0f423025e9cb15c03944c069f5f067e0a07fc692
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+
+--- Page 1 ---
+1Cs-0-3 TSS CqcF Stus suut,Nos c50.q SPECIMENS: A. SENTINEL NODE #1 AND #2 B. RIGHT BREAST C. RIGHT AXILLARY CONTENTS UUID: 8F401B38-8D91-4F75-ADE5-52521EAA7DFE SPECIMEN(S): TCGA-E2-A1LA-01A-PR Redacted A. SENTINEL NODE #1 AND #2 B. RIGHT BREAST  C. RIGHT AXILLARY CONTENTS GROSS DESCRIPTION: A. SENTINEL NODE #1 AND #2 Received fresh labeled with the patient's identification and *sentinel node #1 and #2, right axilla" is a 1.8. x 1.5 x 0.6 cm portion of adipose tissue, within which, two lymph nodes are identified, 0.4 cm( #2) and 0.8 cm( #1). A touch preparation is made on each node. The specimen is entirely submitted as follows: A1- iymph node #1 A2-lymph node #2 B. RIGHT BREAST Received fresh labeled with the patient's identification and designated *right breast" is an oriented (suture in axilla), 358 g, 21 x 17 x 5 cm mastectomy specimen with 7.5 x 5.4 cm beige skin ellipse showing a 1 cm diameter retracted nipple. Ink code: Posterior-deep, anterior/superior-blue, anterior/inferior-orange. The specimen is serially sectioned from lateral to medial into 13 slices revealing two possible lesions. Mass #1, in the upper inner quadrant (two o'clock, slices 9-10), 2 x 1.5 x 1.4 cm, is located 2.2-cm from the deep margin and 1.4-cm from anterior. Approximately 4.5-cm from. mass #1, a second mass is demonstrated in the upper outer quadrant (slice 8), 2 x 1.5 x 1 cm, located 2.5-cm from the deep margin and 1 cm from anterior. A portion of the specimen is submitted for tissue. procurement (mass #1). Representatively submitted: B1-B2: Nipple B3: Skin B4-B5: Mass #1, two o'clock, UIQ, slice 9 B6-B7: Mass #1, two o'clock, UIQ, slice 9 B8: Deep margin overlying mass #1, slice 9 B9: Firm tissue adjacent to mass #1, slice 9 B10-B12: Mass #2, UOQ, slice 8 B13: Deep margin, mass #2, slice 8 B14: Representative section, LOQ, slice 6 B15-B16: Representative sections, LIQ, slice 12 817: Possible axillary lymph nodes C. RIGHT AXILLARY CONTENTS Received fresh labeled with the patient's identification and " axillary contents" is a 10.5 x 10.0 x 2.5 cm. portion of adipose tissue, within which, 34 possible lymph nodes are identified, ranging from 0.1 to 2.5 cm. The cut surfaces of the larger nodes are fatty to soft tan-pink. No evidence of tumor is grossly noted. The specimen is entirely submitted as follows: C1-six lymph nodes C2-six lymph nodes C3-six lymph nodes C4-six lymph nodes C5-seven lymph nodes C6- one lymph node bisected C7-one lymph node bisected C8-C9-one lymph node C10-C14-remaining soft tissue DIAGNOSIS: A. LYMPH NODE, SENTINEL #1 and #2, RIGHT AXILLA, EXCISION: - METASTATIC CARCINOMA TO ONE OF ONE LYMPH NODE (1/1),  MEASURING 8-MM WITH EXTRANODAL EXTENSION. B. BREAST, RIGHT, MASTECTOMY:E
+
+--- Page 2 ---
+TSS: - INVASIVE DUCTAL CARCINOMA, SBR GRADE 2, MEASURING 1.1 CM, PRESENT IN UPPER INNER QUADRANT - HIGH NUCLEAR GRADE, DUCTAL CARCINOMA iN SITU, SOLID type - SURGICAL RESECTION MARGINS NEGATIVE FOR TUMOR - BIOPSY SITE CHANGES WITH FIBROSIS, GRANULATION TISSUE - usual ductal hyperplasia without atypia. - fibroadenoma (0/.7-CM) AND INTRADUCTAL PAPILLOMA (0.2-CM) - SEE SYNOPTIC REPORT. C. LYMPH NODES, RIGHT, AXILLARY DISSECTION: - Thirty-FOUR LYMPH NODES, NEGATIVE FOR METASTASES (0/34). NOTE: Two nodules are grossly identified, one located in the upper inner quadrant and one located in the upper outer quadrant. Microscopically, the former is invasive ductal carcinoma and the later is fibroadenoma. SYNOPTIC REPORT - BREASTE Specimen Type: Mastectomy Needle Localization:.  No Right, Laterality: Invasive Tumor: Present Multifocality: No WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Tumor size:"1.1cm Tumor Site: Upper inner quadrant Margins: Negative Tubular Score: 3 Nuclear Grade: 2 Mitotic Score: 2 Modified Scarff Bloom Richardson Grade:. 2 Necrosis: Absent Vascular/Lymphatic Invasion: None identified Lobular neoplasia: None Lymph nodes: Sentinel lymph node and axillary dissection Lymph node status: Positive 1 / 35 Extranodal extension Micrometastases: No DCIS present Margins uninvolved by DCIS. DCIS Quantity: Estimate 5% DCIS Type: Solid DCIS Location: Associated with invasive tumor. Nuclear grade: High Necrosis: Absent ER/PR/HER2 Results ER: Positive PR: Positive HER2: Negative by FISH Performed on Case: Pathological staging (pTN): pT 1c N 1a CLINICAL HISTORY:S year old with right breast cancer, previous biopsy PRE-OPERATIVE DIAGNOSIS:E
+
+--- Page 3 ---
+TSS  None given INTRAOPERATIVE CONSULTATION TPA: Positive for carcinoma. Called by Dr. to Dr at. Right breast, gross examination: Two possible lesions, mass number one, 1.5-cm located 3.2-cm from deep margin and 1.4-cm from anterior, mass number two, 2-cm in size located 2.5-cm from deep and 1cm from anterior Diagnosis called at . by Dr. ADDENDUM: PathVysion HER-2 DNA Probe Kit Case NoAnalytical Interpretation of Results: HER-2 NOT AMPLIFIED Clinical Interpretation of results Amplification of the HER-2 gene was evaluated with interphase fluorescence in-situ  hybridization (FISH) on formalin-fixed paraffin embedded tissue sections using a chromosome 17 rentromeric probe and a HER-2 probe that spans the entire HER-2 gene in the.  by Dr.. A majority of tumors cells displayed 2 chromosome 17. signals and 2 HER-2 signals, with a HER-2/CEP 17 Ratio </=2.0, consistent with no amplification of the HER2/neu gene. Block used B7 Source of case:Tissue fixation  formalin-fixed tissue Outside Case No:NA Tissue source breast Results interpreted: yes HER2/CEP17 ratio: 1.15 This ratio is derived by dividing the total number of LSI HER-2/neu signals by the total number of CEP17 signals in at least 20 interphase nuclei with nonoverlapping nuclei in the neoplastic mammary epithelial cells. Cells with no signals or with signals of only one color are disregarded. Method of ratio enumeration: manual count Limitations The Vysis PathVysion Kit is not intended for use to screen for or diagnose breast cancer. It is intended to be used as an adjunct to other prognostic factors currently used to predict disease-free and overall survival in stage Il, node-positive breast cancer patients. In making decisions regarding adjuvant CAF treatment, all other available clinical information should also be taken into consideration, such as tumor size, number of involved lymph nodes, and steroid receptor status. No treatment decision for stage Il, node-positive breast cancer patients should be based on HER- 2/neu gene amplification status alone. Overview of this test FDA APPROVED REAGENT  PathVysion HER-2 DNA Probe Kit is FDA approved for selection of natients for whom Herceptin therapy is being considered. These tests were performed in the , under the direction. of Dr.. The results of these studies should always be interpreted in the context of the clinical, morphological, and immunophenotypic diagnosis. Gross Dictation:,   Microscopic/Diagnostic Dictation:,  Microscopic/Diagnostic Dictation.. . Final Review:, Microscopic/Diagnostic Dictation:, - Final Review: Pathologist,. Final: Pathologis! Addendum., Patnoiogist, Addendum Final: Pathologist.
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diff --git a/output/text/31fad782-411d-4cf5-8eed-dedf14e91521.txt b/output/text/31fad782-411d-4cf5-8eed-dedf14e91521.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7a5d5d4896807cf13280c2ac54df238634f41085
--- /dev/null
+++ b/output/text/31fad782-411d-4cf5-8eed-dedf14e91521.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TD-O3 erunone, sguarnsus ce0l UUID:1063C12D-8DD7-4C1E-801E-C2046664DC16 nOS 8ox13 Redacted Site: Coophagus, dlistol thee 015.5 J 1/24)i4 Collect date: (MM/DD/YYYY) PRIMARY SITE: Esophagus (Mid and distal third) PATHOLOGY REPORT: Specimen: Esophagus and proximal stomach Procedure: Esophagectomy and partial gastrectomy Tumor site: esophagus Tumor size (greatest dimension): 6.7 cm Histologic type: Squamous cell carcinoma, ulcerated, Histologic grade: G3 poorly differentiated Microscopic tumor extension: tumor invades through muscularis propria into the adventitia Lymph-vascular invasion: present Perineural invasion: not identified Margins: uninvolved by carcinoma Regional lymph nodes: Number examined: 08 Number positive for neoplasia: 00 ec03
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diff --git a/output/text/3200d192-323f-4c36-84a3-22ac77d99514.txt b/output/text/3200d192-323f-4c36-84a3-22ac77d99514.txt
new file mode 100644
index 0000000000000000000000000000000000000000..01ec95b912a1ca1bed022025064d4087bd1f2996
--- /dev/null
+++ b/output/text/3200d192-323f-4c36-84a3-22ac77d99514.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Jcb-03 Adinorsciwmt, 105 814013 Sit: iocndig Co/ow C18.2 Sample ID #: Diagnosis / Diagnoses: Right hemicolectomy specimen with an ulcerated colon carcinoma conforming to the histological type of a poorly differentiated colorectal adenocarcinoma, located 1.5 cm aborally from Bauhin's valve and circularly occupying the intestinal wall over a length of 8 cm. Invasive spread of tumor within all Iayers of the intestinal wall, extending into the mesocolic fatty tissue and as far as directly below the serosa.. Appendix tumor-free and with post-inflammatory fibrosis of the wall. Oral and aboral resection margins and large omentum tumor-free. 41 regional lymph nodes tumor-free and with uncharacteristic reactive changes Tumor stage thus pT3 pN0 (0/41) L0 V0 R0; G3 UUID: B999FAB8-FBF9-405F-9E6F-81A6E2204363 Redacted TCGA-AA-A00E-01A-PR
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diff --git a/output/text/32104691-825b-4775-ad1b-b40f31dfba07.txt b/output/text/32104691-825b-4775-ad1b-b40f31dfba07.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c29ddccb3b33046bf6e21b4781be8f5a04c0e208
--- /dev/null
+++ b/output/text/32104691-825b-4775-ad1b-b40f31dfba07.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+TCGA-B8-5158 Surgical Pathology Report Diagnosis: A: Kidney, left, radical nephrectomy. Histologic tumor type/subtype: Renal cell carcinoma, clear cell type. Histologic grade (if applicable): Fuhrman nuclear grade 4 (of 4). Tumor size (greatest dimension): 16.0 cm by gross examination Extent of tumor invasion: Capsular invasion/perirenal adipose tissue: Not identified Gerota' s fascia: Not identified Renal vein: Present Ureter: Not identified Venous (large vessel) Present Lymphatic (small vessel): Not identified. Histologic assessment of surgical margins:. Perirenal adipose tissue: Negative. Gerota' s fascia: Negative Renal vein: Negative Renal artery: Negative Ureter: Negative Adrenal gland: Not submitted Lymph nodes: Separately submitted in specimen B Other significant findings: Tumor invades renal sinus soft tissues. AJCC Staging: pT3a pN1 This staging information is based on information available at the time of this report, and is subject to change pending clinical review and additional information. B: Lymph nodes, left hilar, Iymph node dissection - Metastatic renal cell carcinoma in one of fifteen lymph nodes (1/15).. Clinical History: with bilateral renal masses. Gross Description: Received are two appropriately labeled containers. Container A is additionally labeled "left kidney." Specimen fixation: formalin Type of specimen: hand assisted laparoscopic nephrectomy
+
+--- Page 2 ---
+Side of specimen: left Size and weight of specimen: 1,250 grams; 33 x 19 x 10.5 cm overall Orientation: The external surface is inked green.  Presence/absence of adrenal gland: not present Tumor description/site: lower pole of the left kidney; The tumor obliterates the lower pole, greatly expands the capsule inferiorly, fills the pelvis inferiorly, and tracks through the renal parenchyma up to the superior pole. Tumor size: 16 x 7 x 7 cm Presence/absence of multicentricity: The tumor is unicentric Confinement/non-confinement to the kidney: confined; no areas of definite extracapsular extension seen Extent of invasion: Perirenal adipose tissue: defer to histologic sections; grossly confined Gerota' s fascia: not involved (not present on the specimen) Renal vein: involved Ureter: grossly not involved Other organs: not applicable Surgical margins: Perirenal adipose tissue: negative Renal vein: defer to histologic sections Renal artery: defer to histologic sections Ureter: defer to histologic sections Description of kidney away from tumor: brown/tan, unremarkable renal parenchyma Lymph nodes (hilar): per block summary Other significant findings: none Tissue submitted for special investigations: yes; Tumor and normal to Tissue Procurement Digital photograph taken: no Block summary: A1 - ureter and vascular margins A2-A4 - tumor in renal sinus/hilar fat A5 - thick walled vessel/tubular structure in the perirenal fat A6 - renal vein involved by tumor with sections of renal artery grossly negative for tumor A7 - perirenal adipose tissue anteriorly, representative perpendicular margin (widely negative) A8-A9 - tumor at capsule A10-A13 - tumor abutting the capsule A14 - pericapsular adipose tissue and adjacent kidney A15 - tumor and adjacent renal parenchyma A16 - tumor and renal pelvis A17 - tumor and renal pelvis
+
+--- Page 3 ---
+A 18 - superior kidney pole involved by tumor. A19 - grossly uninvolved kidney. A20 - renal fat and capsule. Container B is additionally labeled "left hilar Iymph node." The container holds an aggregate of yellow/tan fibrofatty tissue loosely measuring 5 x 4 x 2 cm. Several significantly enlarged lymph node candidates with rough capsular surface are identified, the largest measuring 2.6 x 1.9 x 1.4 cm.. Block summary: B1-B4 - Iargest lymph node candidate, serially sectioned. B5,B6 - second largest lymph node candidate/several lymph nodes matted together, bisected. B7 - one lymph node candidate. B8 - one lymph node candidate B9 - one lymph node candidate, bisected. B10 - one lymph node candidate, bisected. Fatty tissue remains in the container.. Grossing Pathologist: Light Microscopy: Light microscopic examination is performed.
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diff --git a/output/text/324a3b64-af70-424b-9c6b-94980b6641dd.txt b/output/text/324a3b64-af70-424b-9c6b-94980b6641dd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0c4047f599bec85d54b810367b791d12294875e8
--- /dev/null
+++ b/output/text/324a3b64-af70-424b-9c6b-94980b6641dd.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID: 3EFA8B1E-0FD8-49A4-95FC-4C9C981561A TCGA-E9-A3HO-01A-PR Redacted Procurement Date: Laterality:Left breast Path RepOrt:BREAST TISSUE CHECKLIST Specimen type: Radica! mastectomy Specimen size: Not specified Tumor site: Upper outer quadrant Tumor size: 2.5 x 0 x 3.2 cm Grossly evident lesion: Yes. Histologic type: Lobular carcinoma Histologic grade: Moderately differentiated Tumor extent: Not specified. Lymph nodes: 0/10 positive for metastasis (Axillary 0/10) Extracapsular invasion of the lymph nodes: Not specified Margins: Uninvolved Nottingham Histologic Score Tubule formation: Not specified IcA-0-3 Nuclear pleomorphism: Not specified e50.9 Site: brsot, N0s Mitotic count (25x): Not specified 121n Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None Gross Description:Mammary gland with the tumour of 3.2 x 2.5 cm in size;
+
+--- Page 2 ---
+fatty tissue lymph nodes are free of metastases. Microscopic Description:Infiltrating lobular carcinoma, G2. Ten dissected lymph nodes demonstrate reactive changes. Diagnosis Details:Tumor Features: Unknown, Tumor Extent: T2 tumor size more than 2cm not more than 5 cm, Venous Invasion: Absent, Margins: Absent, Treatment Effect:
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diff --git a/output/text/3273235e-1479-4fd6-94d3-f5341926faeb.txt b/output/text/3273235e-1479-4fd6-94d3-f5341926faeb.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0104bcc35b11f900420b4f87980d751da823d6a2
--- /dev/null
+++ b/output/text/3273235e-1479-4fd6-94d3-f5341926faeb.txt
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+
+--- Page 1 ---
+CL InflrnatNg duct, N05 8500J 3 Carcnoa. i Patient history: Site Code: Draot. Nos 650.9 The patient is a *. -year-oid female with no clinical history or.LMP given.. PRE-OP DIAGNOSIS: Right breast CA. UUID: 38FF655E-47AB-4880-8119-1402A335126A POST-OP DIAGNOSIS: Same. TCGA-BH-A18T-01A-PR Redacted PROCEDURE: Right segmental mastectomy, sentinel node. ADDENDA: Addendum ESTROGEN/PROGESTERONE AND HER-2/NEU REPORT Using appropriate positive and negative controls, the test for the presence of these hormone receptor proteins is performed by the immunoperoxidase method. and reported according to the consensus statement on adjuvant therapy for breast cancer, of. A positive ER or PR tumor shows any nuclear immunostaining, and is semiquantitated as indicated below. Resuit Semiquantitative Statement ER negative Percent cells staining as: (0 100%). PR negative Percent cells staining as: (0 100%). HER-2/neU DAKO hErCEpTeSt: A wEaK tO mODErAtE COmpLeTe mEmBrANe STainIng iS ObSErVED In mORe THAN 10% OF THE TUMOR CELLS. HER-2INEU IS INTERPRETED AS WEAKLY POSITIVE (SCORE 2+). NOTE: Her-2/Neu FISH was ordered and will be subsequently reported. The Her-2/neu and estrogen/progesterone receptor assays were performed with FDA approved methods. FINAL DIAGNOSIS: Part 1: breast, right, segmental mastectomy -- INFILTRATiNg DUCTAL CARCINOmA, 3.1 Cm, pOORLy DIFFEREnTiATED, nOTTIngHAm SCORE = 9/9 7tuBuLes = 3, nuclear graDe = 3, mitoses = 3). B. LYMPHOVASCULAR INVASION IS IDENTIFIED. SEpaRAte fOcI Of Ductal CaRcinoma In SITU, SOLiD Type, high nuCLEaR graDE. THE DUCTAL CARCINOMA iN SITU EXTENDS CLOSE (< 0.1 CM) TO THE POSTERIOR SURGICAL MARGIN Of recection. E. All surgiCal margins Of resection are free Of tumor. F.  NON-NEOPLASTIC BREAST WITH FIBROCYTIC CHANGES. Part 2: sentinel Lymph node #1, right axillA, Biopsy -- ONE (1) LYMPH NODE, NEGATIVE FOR TUMOR (0/1), (see comment). Part 3: sentinel Lymph node #2, right AxillA, biOpsy -- ONE LYMPH NODE, NEGATIVE FOR TUMOR, (0/1).(see comment). Part 4: non-sentinel Lymph node, right axilla, biopsy - One Lymph nOde, nEgative fOR tumor, (0/1). COMMENT: Cytokeratin (AEt/3) stains have been performed and confirm the negative status of the sentinal lymph nodes.
+
+--- Page 2 ---
+MICROSCOPIC: SyNOPTIC - PRIMARy INVASIVE CARCINQMA OF BREAST A. Laterality: 1 1.Right 2. Left 8. Procedure: 1 1. Segmentectomy 2. Simple mastectomy 3. Modified radical mastectomy C. Location: 6 4. Re-excision 1. Central subareolar 2. U0Q 4.L0Q 3. UIQ 5. LIQ D. Size of tumor (maximum dimension invasive component by gross or microscopic exam): 3.1 cm 6. Not specified E. Type (invasive component): 1 1. Ductal, NOS 2. Tubular 5. Cribriform 9. Metaplastic 3. Mucinous 6. Papillary 10. Other 4. Medullary 7. Lobular F. if lobular carcinoma, specify type: N/A 8. Carcinoid like 1. Classical 2. Solid 4. Signet ring 7. Pleomorphic 3. Alveolar 5. Trabecular G. Nottingham Score: 6. Tubulobular G1. Nuclear grade: 3 G2. Tubule formation: 3 G3. Mitotic activity score: 3 G4. Total Nottingham score:  9 G5. Nottingham grade (1, 2, 3): 3 H. Angiolymphatic invasion: 2 1.No 2. Yes I. Dermal lymphatic invasion: 2 1.Yes 2. No 3. Not applicable J. Calciticauon: 1. No 2. Yes -- benign zones K. Type of in situ component: 2  3. Yes -- malignant zones 1. Cribriform 4. Micropapillary 2. Solid 7. Lobular 5. Apocrine  3. Papillary L. Percentage of tumor occupied by in situ component: n/a. 6. Comedo M. Surgical margins involved by invasive component: 1. 1. No 2. Yes -- focal 3. Yes -- diffuse N. Surgical margins involved by in situ component::. 1. No 2. Yes -- foca! 1  3. Yes - diffuse O. Paget's disease of nipple: 2 1. Yes 2. No P. Number of positive lymph nodes:  Q. Total number of lymph nodes examined: 3 R. Sentinel node metastasis: 2 1. Yes 2. No S. Only micrometastases to lymph nodes (none larger than 0.2 cm): n/a. 1. Yes 2. No T. Metastasis/es to a lymph node 2 cm. or more in greatest dimension:  n/a. 1. Yes 2. No U. Lymph node metastasis/es with extracapsular extension: n/a 1. Yes 2. No V. Metastases to ipsilateral internal mammary lymph node (if applicable):  n/a. 1. Yes 2. No W. Skin involved (ulceration): 2 1. Yes 2. No X. Non-neoplastic breast tissue: 6 1.ADH 4. Fibroadenoma 7. LCiS 2. ALH  5. Papilloma 3. Radical scar 8. Other 6.FCD Y. Multicentricity/multifocality of invasive foci: 2 1. Yes 2. No Z. TNM stage: T2nOmX riteri Diag
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diff --git a/output/text/3291504d-628f-44d7-969e-e83a10a69683.txt b/output/text/3291504d-628f-44d7-969e-e83a10a69683.txt
new file mode 100644
index 0000000000000000000000000000000000000000..dd96f12cd6349eb9910f824c7d9dac94b059e576
--- /dev/null
+++ b/output/text/3291504d-628f-44d7-969e-e83a10a69683.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1c)-0-3 C 5e.9 /25 Sr: hrsot, NoS Diagnosis: 1. Poorly differentiated invasive ductal carcinoma with focal intraductal spread (tumor diameter 5 cm). Dorsal resection margin tumor-free.. Tumor classification: NOS, G IIl, pT2N0L0V0R0 UUID:85288EC6-08DC-4955-8888-1DEECBF0E235 Redacted TCGA-A8-A094-01A-PR
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diff --git a/output/text/32f78a3e-a80e-4aca-983b-64c57e5ad879.txt b/output/text/32f78a3e-a80e-4aca-983b-64c57e5ad879.txt
new file mode 100644
index 0000000000000000000000000000000000000000..426ffd56026e7d4145f6f75ecce06600e573c837
--- /dev/null
+++ b/output/text/32f78a3e-a80e-4aca-983b-64c57e5ad879.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TCGA #: Sample ID # Diagnosis: This is a poorly differentiated adenocarcinoma of the ascending colon with partial. neuroendocrine differentiation, with a histopathological grade G3 differentiation, with extensive necroses, with substantial with peritumorous, chronic inflammation, with tumor infiltration in the layers of the colon wall as far as the pericolic fatty connective tissue,. with carcinomatous lymphangiosis, with a regional lymph node metastasis (1/21), tumor- free overview sections from the resection margins and from the attached reticular fatty. tissue, as well as chronic appendicitis.. According to these prepared sections, the tumor spread of the colon carcinoma. corresponds to the tumor stage pT3, pN2, MX, L1 ICs-0-3 8140|3 Adenocscioma, nos Srtx: asending cr!onC18.7 pw 3/30/1 UUID:8547AC20-9066-452B-BB3D-AF6618445A790 Redacteo
\ No newline at end of file
diff --git a/output/text/32ffb960-ca14-4aea-a8f4-2148430aa5af.txt b/output/text/32ffb960-ca14-4aea-a8f4-2148430aa5af.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a87129c784184e0f788f5b7b8a9b70437c0910a5
--- /dev/null
+++ b/output/text/32ffb960-ca14-4aea-a8f4-2148430aa5af.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+Ccruinonn,snfiltrstng ouctl,n1s 85oof3 Sits: brust Nos C50.9 yasf iw Chiet of Fathology Phone Yax Speciaen: Received: Status: Spec Type: SURGICAL P Rug$: Subm Dr: BRKAST CANCER INVASIVE DATE: DOCTOR(s) : pRoceDurE: A. RT BREAST DEEP MARGIN B. LT BREAST C. RT PREAST AND AXILLARY NODES UUID:5A038697-F097-496C-9788-F7380A5394A7 TCGA-A2-A1G4-01A-PR Redacted RECRIVED Rrs. LABELED RIGHT DEEP MARGIN INK MARKS NEW ARRRGULAR PORTION OF YELLOW FATTY AND BRONN MUSCULAR TISSUE MEr.. .NG 4.8 X 2.2 X 0.6 CM IN GREATEST DIMENSIONS. ONE SIDE OF THE SPECIMEN IS RECEIVED MARKRD WITH BLUE INK. WJTH p-JE INv TH A PERIMETER OF RED INK.S  THIS SIDE IS FURTHER MARKED 3D LABELED A1 THROUGH A3. THE SPECIMEN IS SECTIONED AND PA ABELED MAST LEFT BREAST IS A SIMPLE KN MEASURING 24.5 X 21 x 3.8 CM. A SUTURE DENOTES 12 O' CLOL.. THE NI PLK IS FLAT WITHIN A 23.7 X 15.3 CM SKIN ELLIPSE. THE 9 O'CLOCK AREA OF THE BREAST THERE IS A O.5 CM IN DIAMETER FLOWER-SHAPED RED-BROWN SKIN LESION. IN NITH BLUE INK, THE DEEP WITH BLACK INK. SECTIONING REVEALS THE SPECIMEN  THE SUPERFICIAL ASPECT IS MARKED TO CONSIST OF BLAND YELLOW FATTY TISSUE WITH FINE FIBROUS BANDS. ARE NODULAR FIRM AREAS NOTRD CENTRALLY THAT DO NOT FORM DISCRETE MASSES. SECTIONS ARE SUBMITTED AS FOLLOWS: B1--NIPPLE AND DESCRIBKD SKIN LESION, THERE B2--CENTRAL DEEP MARGIN, B3 AND B4--UPPER OUTER QUADRANT, B5 AND B6--UPPER INNSR QUADRANT, B7 AND B8-~LOWER INNER QUADRANT, B9 AND B10--LOWER OUTER QUADRANT, B11--TISSUE CENTRAL. B7, B9, AND BI1 ARE MIRROR IMAGE TISSUE TAKEN PER PROTOCOL.  NOTE THAT B1, B3, B5, ADDITIONAL SECTIONS FROM THE LOWER INNER QUADRANT ARE SUBMITTED LABELED B12 THROUGH B14, A SECTION FROM THE SUBAREOLAR AREA IN B15, AND ADDITIONAL TISSUE FROM THE UPPER OUTER QUADRANT B16 AND 17. PART C RECEIVED LABELEDS NODE IS A RIGHT MODIFIED RADICAL MASTECTOMY SPECIMEN NITH FRAGMENTS OF RIGHT BRKAST AND AXILLARY LYMPH LOOSE TISSUE WHICH ALSO DEMONSTRATE PALPABLE LYMPH NODES. THE OVERALL DIMENSIONS ARE 30 X 22 X 4.3 CM. THE NIPPLE IS FLATTENED. IMMEDIATELY
+
+--- Page 2 ---
+Chiet of Fathology Phone Tax Specimen: Received: Status: Req#: Spec Type: SURGICAL P Subm Dr: (Continued) LATERAL TO THE NIPPLE IS A PALPABLE MASS.  THE SKIN ELLIPSE MEASURES 22.6 X 14.O CM. A SMALL RAISED PIGMENTED LESION IS FOUND IN THE LOWER OUTER QUADRANT ADJACENT TO THE SKIN RESECTION MARGIN MEASURING O.4 CM IN DIAMETER.  THE SUPERFICIAL ASPECT IS MARKKD IN BLUE INK, THE DEEP ASPECT WITH BLACK INK.  WHERE THE AXILLARY TAIL IS REMOVED, IT IS MARKED IN RED AND DOES NOT REPRBSENT TRUE MARGIN. THE AXILLARY TAIL IS EXAMINED FOR LYMPH NODES. IN THE LOW AXILLARY TAIL, THERE IS A 2.8 CM CENTRALLY FAT-REPLACED LYMPH NODE WITH A COIL CLIP. ONE HALF IS SUBMITTED PER PROTOCOL.  THE REMAINDER IS SUBMITTED AS C1. A SECOND LOW NODE IS GROSSLY POSITIVE 1.6 CM IN GREATEST DIMENSION. ONE HALF IS SUBMITTED AS C2 WITH THE REMAINDER SUBMITTED PER PROTOCOL. ADDITIONAL NODES ARE THEN SUBMITTED AS FOLLOWS: C3--ONE HALF GROSSLY UNREMARKABLE LYMPH NODE (MIRROR IMAGE TO PROTOCOL). C4--TWO NODES EACH BISECTED, C5--ONE NODE BISECTED, C6--ONE NODE BISECTED, C7--ONE NODE BISECTED. C8--TWO NODES EACH BISECTED, C9--FOUR NODES, C1O--TWO NODES KACH BISECTED, C11 AND C12--ONE NODE TOTAL.  SECTIONING REVEALED THE BREAST TO CONSIST OF BLAND YELLOW FATTY TISSUE WITH FINE FIBROUS BANDS. THE PALPABLE MASS IS ILL-DEFINED WITH PINK-TAN TISSUE INTERSPERSED IN THE YELLOW-FATTY TISSUE. THIS EXTENDS FROM THK SUBAREOLAR AREA IN THE LONER OUTER QUADRANT MEASURING 6 CM FROM MEDIAL TO LATERAL BY PALPATION 6.5 CM FROM SUPERIOR TO INFRRIOR AND 4 CM FROM SUPERFICIAL TO DEEP IN AN ILL-DEFINED MANNER. GROSSLY THIS EXTENDS TO WITHIN O.5 CM OF THE DEBP MARGIN. SECTIONS ARR SUBMITTED AS FOLLOWS: C13--NIPPLE (MIRROR IMAGE TO PROTOCOL), C14 AND C15--LESION AND CLOSEST GROSS DEEP MARGIN, C16--THE MOST LATERAL ASPECT OF THE LESION (MIRROR IMAGE TO PROTOCOL), C17--THE MOST CENTRAL AND MEDIAL PORTION OF THE LESION (MIRROR IMAGE TO PROTOCOL), NOTE THAT C16 AND C17 ARE 6 CM APART, C18--TUMOR (MIRROR IMAGE TO PROTOCOL), C19--THE MOST INFERIOR ASPECT OF THE LESION WITH INFERIOR SUPERFICIAL MARGIN, C20--THE SUPERIOR PORTION OF THE LESION OR ADJACKNT TO MARGIN CENTRAL SPECIMEN, C21--UPPER OUTER QUADRANT, C22--LOWER INNER QUADRANT, C23--UPPER INNER QUADRANT, C24 AND C25--ADDITIONAL SECTIONS OF CENTRAL TUMOR (MIRROR IMAGE TO PROTOCOL). PROCEDURES : 88307/2, 88309, A BLK/3, B BLK/17, C BLK/25, BR PR KI67 HER2 PART A RIGHT BREAST DEEP MARGIN REEXCISION: FIBROADIPOSR TISSUE AND SKELETAL MUSCLE WITH NO EVIDENCE OF MALIGNANCY. THE NEW INKED MARGIN IS FREE OF NEOPLASM. PART B LEFT BREAST, SIMPLE MASTECTOMY: 1. INFILTRATING LOBULAR CARCINOMA, NUCLEAR GRADE I WITH LOW MITOTIC INDEX, IDENTIFIED IN THE LOWER INNER QUADRANT WITH AN ESTIMATKD TUMOR DIMENSION OF 21 MM (SLIDES B7, B8, B12-14).
+
+--- Page 3 ---
+Chisf of yathology Phone Yax Specimen: Raceived: Spec Type: Status:  SURGICAL P Subm Dx: Rea#: (Continued) 2. THE NIPPLE AND DEEP MARGIN ARE FRKK OF NEOPLASM.S 3. LYMPHATIC INVASION IS NOT IDENTIFIED.S PROLIFERATIVE FIBROCYSTIC DISKASE WITH A FOCUS OF LOBULAR CARCINOMA IN SITU IDENTIFIED IN THE UPPER OUTER QUADRANT ALONG WITH SCLKROSING ADENOSIS, DUCT HYPERPLASIA OF THE USUAL TYPK, APOCRINE METAPLASIA AND CYST FORMATION. PART C RIGHT BREAST, MODIFIED RADICAL MASTECTOMY:S LARGE MODKRATELY DIFFERENTIATED INTRADUCTAL AND INFILTRATING DUCT CARCINOMA, NUCLEAR GRADE II WITH LOW MITOTIC INDEX NITH FOCI OF MOCINOUS DIFFKRENTIATION SPANNING A DISTANCE OF 65 MM. 2 THX DEEP MARGIN IS FRER OF NEOPLASM. DUCTAL: CARCINOMA IN SITU INVOLVES THE NIPPLE. 3. LYMPHATIC INVASION IS PRESENT. METASTATIC CARCINOMA TO 1 OF 15 AXILLARY LYMPH NODKS. *. DENONSTRATRS PRKVIOUS BIOPSY SITE CHANGE BUT NO RESIDUAL NEOPLASM.  ONE LYMPH NODE 5. HEMANGIOMA, SKIN OF BREAST. RECEPTOR AND PROGNOSTIC FACTOR DETERMINATION WILL BE PERFORMED ON BLOCK B7. - ESTROGEN RECSPTOR: POSITIVE Nuclei stained: 100t Intensity: 3 Reference Range: Negative <lt PROGBSTERONE RECEPTOR: NEGATIVE Positive >- 1t Nuclei stained: 0 Intensity: 1 Reference Range: Negative <lt Her-2/neu: NEGATIVE Positive > 1t Score: 1+ Reference Range: Negative 0 - 1+ Equivocal 2+
+
+--- Page 4 ---
+Chief ot Fatheleey Phone Fax (r Specimen: Received: Status: Reg#: Spec Type: SURQICAL P Subm Drt (Continued) Positive 3+ Kt~67: LOW Nuclei stained: 3t. Intensity: Reference Range: Low <l0t Borderline 10-20t High >20t Klectronically signed by:. See full scanned report for details. Test performed at: :. 1. Skr To: 2. REgUESTED BYs 3. DATs SKTs 4. KETHOD OF TRANSPORTATION:S 5. NO. oF BLOCKS: 7. KATKRIAL(S) TO BB RETURNED:S 14. 8pSCIMKK sKwT(Y/M) :  Signed (prelim.) (signature on file).
\ No newline at end of file
diff --git a/output/text/3306e681-36cb-4c57-8dd3-958e1f9aba32.txt b/output/text/3306e681-36cb-4c57-8dd3-958e1f9aba32.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ee012a98d3a12a93d2280d61d9c56e8237ff1045
--- /dev/null
+++ b/output/text/3306e681-36cb-4c57-8dd3-958e1f9aba32.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Redacted 11 Final Diagnosis Seast, left, simple mastectomy: Infiltrating ductal carcinoma, with micropapillary differentiation, Nottingham grade III (of III) [tubules 3/3, nuclei 3/3, mitoses 2/3; Nottingham score 8/9], forming multiple (2) masses located in the lower outer quadrant. adjacent to prior core biopsy site (3 o' clock--1.1 x 1.0 x 1.0 cm; 4 o' clock--1.6 x 1.5 x 1.5 cm) [AJCC pT1c]. Angiolymphatic invasion is present. The non-neoplastic breast parenchyma shows nonproliferative fibrocystic changes. Biopsy site changes in the upper outer quadrant (status post lumpectomy), negative for residual tumor. Nipple and skin without diagnostic abnormality. Skeletal muscle is present and not involved by tumor. All surgical resection margins, including the deep margin, are negative for tumor (minimum tumor free margin, 0.6 cm, superior anterior margin). Lymph nodes, left axillary, excision: A single (of 5) left axillary lymph node is positive for metastatic carcinoma. Extranodal. extension is present. /cs-0-3 carcinomn, mifiltruthg cuct, Nos 85ow/3 Sitr: brsst, Nos c5o.9 h y/05/
\ No newline at end of file
diff --git a/output/text/33104831-3499-4da1-80ba-88e4a4b22c31.txt b/output/text/33104831-3499-4da1-80ba-88e4a4b22c31.txt
new file mode 100644
index 0000000000000000000000000000000000000000..52c2524aa1eb7b61a020c5fd0cc5ef4b1f6334fb
--- /dev/null
+++ b/output/text/33104831-3499-4da1-80ba-88e4a4b22c31.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+IcD-0-3 8140/3 adinvcurcinomn N1 s Site : cecum C18.0 p 3/29f1 Jample ID # Diagnosis: 1.: Tumor-free lipomatous atrophic lymph node. 2.: Right hemicolectomy specimen with tumor-free resection margins and under inclusion. of an ulcerated, malignant, solid tumor in the cecum, conforming to the type of a poorly differentiated adenocarcinoma, with infiltration of the lamina muscularis propria and without regional lymph node metastases (G3, pT2 L0 V0 R0 pN0 0/27). Additional immunohistological investigations are being conducted due to the histological. peculiarities of the tumor. A follow-up report on this will be submitted at a later date. Follow-up report: From an immunohistological perspective, the tumor cells were positive for broad-. spectrum cytokeratins. Large numbers of CD3-positive and CD20-negative or T- lymphocytes are also interspersed. Based on the histology and immunohistology, this is thus a poorly differentiated colorectal adenocarcinoma, or cecum carcinoma, with a dense lymphocytic stromal infiltrate. The poor tumor differentiation and the dense lymphocytic inflammatory infiltration may. be indicators of the presence of a microsatellite unstable (possibly HNPCC-associated) colorectal carcinoma. JUID:A4 -PR
\ No newline at end of file
diff --git a/output/text/331169f6-72a2-4ad6-bfe4-8d139b69f98b.txt b/output/text/331169f6-72a2-4ad6-bfe4-8d139b69f98b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8926dd6714bbc73aed1165379d0cd7a7d0d5861b
--- /dev/null
+++ b/output/text/331169f6-72a2-4ad6-bfe4-8d139b69f98b.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID: D8EFF862-6A23-4033-8144-248751DECB08 TCGA-A7-A331-01A-PR Redacted /c) 0-3 Final Surgical Pathology Report. lw Procedure: 13/8/n Diagnosis A. Sentinel lymph node, left axilla, biopsy: A single lymph node is negative for malignancy B. Breast, left, excisional biopsy: Invasive lobular carcinoma, Nottingham grade 2. Note: The margins are negative for malignancy c. Breast, posterior lateral margin, biopsy: Focal lobular carcinoma in situ, negative for invasive carcinoma Microscopic Description: A. A single lymph node is negative for malignancy. [At the request of some staff oncologists and in keeping with the opinion of some experts in breast pathology, immunohistochemical stains. for keratin were not used on the sentinel iymph node sections in this. case. These stains can be obtained if desired.  Our paraffin blocks are retained for 10 years. (Weaver DL et al. New Engl J Med 364:412, 2011. Schwartz GF et al. Cancer 94(10):2542, 2002)]. Invasive carcinoma: Histologic type: Invasive lobular carcinoma Nottingham grade: Architectural score: 3 Nuclear score: Mitotic score: Mitotic index: 0 mitoses/ 10 HPFs (1 HPF = 1.96 sq. mm) Tumor size: 1.7 cm Specimen margins: Negative for malignancy.. Carcinoma is 1.2 mm from the red (anterior) inked margin in block Bl5. Vessel invasion:  Absent Calcification: Absent Non-tumorous breast: Fat necrosis, compatible with prior biopsy site pTNM stage: T1c NO Prognostic markers: No previous biopsy here.. Markers are available if needed. Antibody...Results...Comment ck5/6 ...Positive E-cadherin ...Positive Lobular carcinoma in situ is present. Antibody...Results...Comment E-cadherin ... Negative Paraffin sections; 10% neutral buffered formalin; Controls stain appropriately.
+
+--- Page 2 ---
+[A few of the antibodies used in our laboratory may be classified as analyte specific reagents. These antibodies are monitored and controlled in our laboratory and their performance for in vitro diagnosis is well described in the medical literature. They have not been cleared or approved by the FDA.] Specimen A. Left axillary sentinel node B. Left breast biopsy long anterior short superior C. Posterior lateral margin long anterior short superior Clinical Information. Cancer diagnosed in Gross Description. A. Specimen A. is received unfixed labeled axillary sentinel node and consists of 3 pieces of yellow soft tissue measuring 2.5 x 2 x 1 2.5 x B. The specimen is received unfixed in the Transpec container labeled left breast biopsy and consists of yellow and red piece of soft tissue measuring 8.5 by 6 by approximately 2.5 cm. The external surface the specimen is inked as indicated below. Anterior: Red Posterior:  Orange Lateral:  Blue Medial: Green Superior: Yellow Inferior: Black There is a firm area near one end of the specimen measuring 1.5 by 1.7 cm in greatest dimension. A small portion of the tumor is taken for research purposes. Sections after fixation. Rs-16 Specimen c. is received unfixed labeled posterior lateral margin and consists of a yellow piece of soft tissue measuring 3.4 x 2.5 x 1.5 cm. There is along the short suture on the specimen. The external surface of the specimen is inked as indicated below. Anterior: Red. Posterior: Orange Lateral: Blue Medial: Green Superior: Yellow Inferior: Black Sections after fixation
\ No newline at end of file
diff --git a/output/text/331f5224-6964-4a54-8137-335a926f8eec.txt b/output/text/331f5224-6964-4a54-8137-335a926f8eec.txt
new file mode 100644
index 0000000000000000000000000000000000000000..184da545c2e2dbb9e87f7b7a7ba8abb8af8945a3
--- /dev/null
+++ b/output/text/331f5224-6964-4a54-8137-335a926f8eec.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+IcD-o-3 arcinsmo-, popil/ary reral cel1 8Q60f3 -A5W7-01A-PR Redacted Sitc:B Kidney.NOS C64.9 n 3/18/13 Diagnosis: A: Kidney, right, anterior renal mass, partial nephrectomy Procedure: partial nephrectomy Laterality: right Histologic tumor type/subtype: papillary renal cell carcinoma Sarcomatoid features: absent. Histologic grade (if applicable): 3 Tumor size (greatest dimension): 1.5 cm. Tumor focality: multifocal (see parts B and c) Extent of tumor invasion (if present specify if macroscopic or microscopic): Capsular invasion/perirenal adipose tissue: absent Histologic assessment of surgical margins: Renal parenchymal margin (partial nephrectomy only): positive B: Kidney, right, posterior medial renal mass, partial nephrectomy Procedure: partial nephrectomy Laterality: right Histologic tumor type/subtype: papillary. Sarcomatoid features: absent Histologic grade (if applicable): grade 3 Tumor size (greatest dimension): 3.8 cm Tumor focality: multifocal
+
+--- Page 2 ---
+Extent of tumor invasion (if present specify if macroscopic or microscopic): Capsular invasion/perirenal adipose tissue: negative Histologic assessment of surgical margins:. Renal parenchymal margin (partial nephrectomy only): negative C: Kidney, right, posterior lateral renal mass, partial nephrectomy Procedure: partial nephrectomy. Laterality: right Histologic tumor type/subtype: papillary Sarcomatoid features: absent. Histologic grade (if applicable): 3 Tumor size (greatest dimension): 2.5 cm. Tumor focality: multifocal. Extent of tumor invasion (if present specify if macroscopic or microscopic) : Capsular invasion/perirenal adipose tissue: negative Histologic assessment of surgical margins:. Renal parenchymal margin (partial nephrectomy only): negative AJcc Staging: prTla pNx This staging information is based on information available at the time of this report, and is subject to change pending clinical review and additional information..
+
+--- Page 3 ---
+Clinical History: -year-old male with right renal mass. Per , the patient has a history of renal cell carcinoma. Gross Description: Received are three appropriately labeled containers. Container A is additionally labeled "kidney, right, anterior renal mass, partial nephrectomy" and consists of a 10.6 gram, 3.5 x 3.0 x 2.1 cm brown/tan fragment of kidney. The surgical margin is inked black. The renal capsule is inked yellow. A defect, 1.2 x 0.8 cm is identified and the external surface around the defect is inked yellow. The specimen is serially sectioned perpendicular to the blue and black inked tube margin. Sectioning reveals a pale tan, at least 1.5 x 1.2 x 1.0 cm well- circumscribed mass. The yellow inked defect goes right through this mass. The mass abuts the yellow-inked margin, black-inked margin and is less than 1 mm from the blue inked margin. The adjacent renal parenchyma is yellow to brown/tan, homogeneous. Block Summary: Al - Perpendicular sections of the first slice with blue inked margin, including closest approach of the mass A2-A3 - Representative sections of the mass with adjacent uninvolved renal parenchyma A4 - Additional representative section of the mass Container B is additionally labeled "kidney, right, posterior medial renal mass, partial nephrectomy" and consists of a 28.0 gram, 4.0 x 3.7 x 3.0 cm fragment of kidney, that was received with a prior cut for tissue procurement. The capsule is inked blue and the surgical margin is inked black. Sectioning reveals a pale tan, friable, well-circumscribed mass, 3.8 x 3.6 x 2.9 cm. Focal gray to red/tan areas consistent with necrosis and hemorrhage respectively, are identified. Normal renal parenchyma is not identified in the specimen. The mass is O.1 cm from the blue and black inked margins. Representative sections, including closest approach to the margin are submitted in blocks B1-B2. Representative sections from the grossly necrotic and hemorrhagic area is submitted in block B3. Container c is additionally labeled "kidney, right, posterior lateral renal mass" and consists of a 13.5 gram 3.4 x 2.7 x 2.2 cm fragment of kidney, with a 3.5 x 1.7 x 0.6 cm fibroadipose tissue attached. The capsule is inked blue and the resection
+
+--- Page 4 ---
+margin is inked black. The capsule is yellow to brown/tan, smooth, and unremarkable. Sectioning reveals a pale tan friable mass, 2.5 x 2.5 x 2.1 cm. The mass is hemorrhagic in the center,. abuts the blue inked capsule and is 0.2 cm from the black inked. resection margin. Block Summary: C1-c2 - Representative sections of the mass, depicting closest. approach to the margins c3 - Representative section of the mass with the attached. fibroadipose tissue fragment 22513
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diff --git a/output/text/331f532c-fa3a-4cd8-ad52-48b2c3f57939.txt b/output/text/331f532c-fa3a-4cd8-ad52-48b2c3f57939.txt
new file mode 100644
index 0000000000000000000000000000000000000000..80d576df1b90f8284843185fca628f9e21a68b35
--- /dev/null
+++ b/output/text/331f532c-fa3a-4cd8-ad52-48b2c3f57939.txt
@@ -0,0 +1,30 @@
+
+--- Page 1 ---
+SURGICAL PATHOLOGY REPORT Accession number: Final Report DIAGNOSIS: 1-11) SKIN, NERVE, TONGUE AND ORAL MUCOSA, VARIOUS SITES AS LISTED, BIOPSY: NEGATIVE FOR MALIGNANCY AT EACH SITE. 12) LYMPH NODES, LEVEL 1A, DISSECTION: TWO LYMPH NODES NEGATIVE FOR MALIGNANCY (0/2) 13) LYMPH NODES, LEVEL 2, DISSECTION: 10 LYMPH NODES NEGATIVE FOR MALIGNANCY (0/10). 14) LYMPH NODES, LEVEL 3, DISSECTION: 13 LYMPH NODES NEGATIVE FOR MALIGNANCY (0/13). 15) LYMPH NODES, LEVEL 4, DISSECTION: EIGHT LYMPH NODES NEGATIVE FOR MALIGNANCY (0/8). 16) TONGUE, JAW, FACIAL SKIN, BUCCAL MUCOSA, EXCISION: INVASIVE SQUAMOUS CELL CARCINOMA, MODERATELY DIFFERENTIATED, 4.2 CM IN GREATEST EXTENT, WITH INVASION INTO MANDIBLE; SURGICAL MARGINS NEGATIVE FOR MALIGNANCY, CLOSEST MARGIN POSTERIOR AND MEDIAL O.3 CM; SUBMANDIBULAR GLAND WITH NO SIGNIFICANT HISTOPATHOLOGIC CHANGE; TWO LYMPH NODES INVOLVED BY SQUAMOUS CELL CARCINOMA. (SEE COMMENT). COMMENT: These findings correspond to AJCC stage p4a (pT4a,pN2,pMn/a) Upper Aerodigestive Tract and Minor Salivary Glands Carcinoma Summary of Findings: Incisional and Excisional Biopsy, Resection. Note: Check 1 response unless otherwise indicated. MACROSCOPIC Specimen Type Incisional biopsy Excisional biopsy X Resection (specify type): composite resection of tongue, jaw, neck, floor of mouth. Other (specify):
+
+--- Page 2 ---
+Not specified Tumor Site (check all that apply) Lip X Oral cavity Pharynx, oropharynx Pharynx, hypopharynx Pharynx, nasopharynx Larynx, supraglottis Larynx, glottis Larynx, subglottis Paranasal sinus(es), maxillary Paranasal sinus(es), ethmoid Other (specify): Not specified Tumor Size Greatest dimension: 4.5 cm *Additional dimensions: 3.5 x 0.8 cm Cannot be determined (see Comment). MICROSCOPIC Histologic Type Carcinomas of the Upper Aerodigestive Tract X  Squamous cell carcinoma, conventional Squamous Cell Carcinoma, Variant Verrucous carcinoma Spindle cell squamous carcinoma Adenosquamous carcinoma Basaloid squamous cell carcinoma Papillary squamous cell carcinoma  Lymphoepithelioma-like carcinoma (non-nasopharyngeal) Sinonasal Carcinoma Keratinizing sinonasal carcinoma Non-keratinizing sinonasal carcinoma (Transitional type) Sinonasal undifferentiated carcinoma (SNUC) Nasopharyngeal Carcinoma Keratinizing nasopharyngeal carcinoma Non-keratinizing nasopharyngeal carcinoma Non-keratinizing nasopharyngeal carcinoma, differentiated Non-keratinizing nasopharyngeal carcinoma, undifferentiated (lymphoepithelioma)  Non-keratinizing nasopharyngeal carcinoma, mixed differentiated and undifferentiated Adenocarcinoma, salivary gland type (specify type):
+
+--- Page 3 ---
+Adenocarcinoma, Non-salivary Gland Type. Papillary adenocarcinoma Intestinal-type adenocarcinoma Adenocarcinoma not otherwise specified (NOs), low grade Adenocarcinoma NOS, intermediate grade Adenocarcinoma NOs, high grade Neuroendocrine carcinoma Typical carcinoid tumor (well differentiated neuroendocrine carcinoma) Atypical carcinoid tumor (moderately differentiated neuroendocrine. carcinoma) Small cell carcinoma (poorly differentiated neuroendocrine carcinoma) Other (specify): Carcinoma, type cannot be determined Histologic Grade Not applicable GX: Cannot be assessed G1: Well differentiated X G2: Moderately differentiated G3: Poorly differentiated Other (specify): Pathologic Staging (pTNM) (see appropriate site below) Note: The phrases in italics include clinical findings required for AJCC. staging. This clinical information may be unknown to the pathologist. It is. included here only for the sake of completeness. Primary Tumor (pT): Oropharynx pTX: Cannot be assessed pTO:  No evidence of primary tumor pTis: Carcinoma in situ pT1:  Tumor 2 cm or less in greatest dimension. pT2:  Tumor more than 2 cm but not more than 4 cm in greatest dimension  pT3: Tumor more than 4 cm in greatest dimension. X pT4a: Tumor invades larynx, deep/extrinsic muscle of tongue, medial. pterygoid muscles, hard palate, or mandible. pT4b: Tumor invades lateral pterygoid muscle, pterygoid plates, lateral nasopharynx, or skull base, or encases carotid artery Regional Lymph Nodes (pN): All Aerodigestive Sites Except Nasopharynx pNX:Cannot be assessed - pN0: No regional lymph node metastasis - pN1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension  pN2a: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension. X pN2b:  Metastasis in multiple ipsilateral lymph nodes, none more than. 6 cm in greatest dimension - pN2c: Metastasis in bilateral or contralateral lymph nodes, none
+
+--- Page 4 ---
+more than 6 cm in greatest dimension pN3: Metastasis in a lymph node more than 6 cm in greatest dimension Specify: Number examined: 35 Number involved: 2 *Extra-capsular Extension of Nodal Tumor * X Absent * Present  Indeterminate Distant Metastasis (pM) X pMX:  Cannot be assessed pM1:Distant metastasis *Specify site(s), if known:. Margins (check all that apply) Cannot be assessed X Margins uninvolved by tumor Distance of tumor from closest margin: 3 mm Specify margin, if possible: posterior and medial X Carcinoma in situ absent Carcinoma in situ present Carcinoma in situ, not applicable Margin(s) involved by tumor Specify margins(s), if possible: Not applicable *Venous/Lymphatic (Large/Small Vessel) Invasion (V/L) *X Absent _ Present  Indeterminate Perineural Invasion X Absent Present *Additional Pathologic Findings (check all that apply) None identified. Carcinoma in situ. * Inflammation (specify type): * Epithelial hyperplasia * Epithelial dysplasia * Other (specify): *Comment(s) Data elements with asterisks are not required for accreditation purposes for the Commission on Cancer. These elements may be clinically important but are not yet validated or regularly used in patient management. Alternatively, the necessary data may not be available to the pathologist. at the time of pathologic assessment of this specimen **Electronically Signed Out by
+
+--- Page 5 ---
+CLINICAL DATA Clinical Features: received on towel with orientation to superior Operator: Operation: Unspecified Operative Findings: Unspecified Operative Diagnosis: Unspecified Tissue Submitted:  1) anterior inferior skin margin, 2) anterior superior skin margin, 3) posterior inferior skin margin, 4) posterior superior skin margin, 5) lingual nerve, 6) floor of mouth, mucosal margin, 7) ventral tongue, mucosal margin, 8) retromolar trigone mucosal margin, 9) soft palate mucosal margin, 10) buccal mucosal margin, 11) lip mucosa. margin, 12) level A1 neck dissection, 13) left neck level 2, 14) left neck level 3, 15) left neck level 4, 16) tongue, jaw, level 1B, facial skin and mucosal margin INSTRUCTIONS TO PATHOLOGIST: High risk HPV ISH and P16 IHC on permanent section. GROSS DESCRIPTION: 1) SOURCE: Anterior Inferior Skin Margin Received fresh in a container labeled with the patient's name is a single portion of skin measuring 7.0 x 0.1 cm and excised to a depth of 0.3 cm. The specimen is entirely submitted for frozen section diagnosis, following inking for orientation: blue at superior or black at inferior. Summary of sections: 1AFSC, 1/1. 2) SOURCE: Anterior Superior Skin Margin. Received fresh in a container labeled with the patient's name is a single portion of skin measuring 5.0 x 0.1 cm and excised to a depth of 0.2 cm. The specimen is entirely submitted for frozen section diagnosis, following inking for orientation: blue at superior or black at inferior. Summary of sections: 2AFSC, 1/1. 3) SOURCE: Posterior Inferior Skin Margin. Received fresh in a container labeled with the patient's name is a single portion of skin measuring 4.6 x 0.2 cm and excised to a depth of 0.3 cm. The specimen is entirely submitted for frozen section diagnosis, following inking for orientation: blue at superior or black at inferior. Summary of sections: 3AFSC, 1/1.
+
+--- Page 6 ---
+4) SOURCE: Posterior Superior Skin Margin Received fresh in a container labeled with the patient's name is a single portion of skin measuring 5.2 x 0.2 cm and excised to a depth of 0.3 cm. The specimen is entirely submitted for frozen section diagnosis, following inking for orientation: blue at superior or black at inferior.. Summary of sections: 4AFSC, 1/1. 5) SOURCE: Lingual Nerve. The specimen labeled "lingual nerve" is received fresh for intraoperative consultation and consists of a 0.2 x 0.2 x 0.1 cm segment of flat, tan to yellow tissue. The specimen is submitted en entirety for frozen section. analysis. Summary of sections: 5AFSC, lingual nerve, 1/1. 6) SOURCE: Floor of Mouth Mucosal Margin The specimen labeled "floor of mouth mucosal margin" is received fresh for intraoperative consultation and consists of a flat segment of tan to red tissue measuring 2.6 x 0.3 x 0.1 cm segment. The sample is received with a mark denoting the inferior portion of the sample. This area is marked in black. The sample is received on a cloth towel. The specimen is submitted in entirety for frozen section analysis.Summary of sections: 6AFSC, 1/1. 7) SOURCE: Ventral Tongue Mucosal Margin The specimen labeled "ventral tongue mucosal margin" is received fresh for intraoperative consultation on a cloth towel and consists of a flat, tan segment of tissue measuring 3.5 x 0.2 x 0.2 cm segment. The specimen is received with a mark denoting the inferior portion of the sample. This area is inked black. The specimen is submited in entirety for frozen section analysis. A portion of the specimen was destroyed during frozen section processing. The remainder of the specimen is submitted for permanent section. Summary of sections: 7AFSC, 1/1. 8) SOURCE: Retromolar Trigone Mucosal Margin The specimen labeled "retromolar trigone mucosal margin" is received fresh for intraoperative consultation and consists of a flat tan segment of tissue measuring 0.7 x 0.3 x 0.2 cm. The specimen is received on a cloth towel. The sample is received with a mark denoting the inferior aspect. This portion of the specimen is inked in black. The sample is submitted in entirety for frozen section analysis.Summary of sections: 8AFSC, retromolar trigone mucosal margin, 1/1.. 9) SOURCE: Soft Palate Mucosal Margin The specimen labeled "soft palate mucosal margin" is received fresh for intraoperative consultation on a cloth towel and consists of a flat section of tan to pink tissue measuring 1.8 x 0.2 x 0.1 cm. The specimen is received with a mark denoting the inferior aspect of the specimen; this. portion is inked in blue. The specimen is submitted in entirety for frozen
+
+--- Page 7 ---
+section analysis.Summary of sections: 9AFSC, soft palate mucosal margin, 1/1. 10) SOURCE: Buccal Mucosal Margin The specimen labeled "buccal mucosal margin" is received fresh for intraoperative consultation on a cloth towel. The specimen measures 5.7 x 0.3 x 0.2 cm segment. The sample is received with a mark denoting the inferior portion of the sample; this portion of the specimen is inked in blue. The specimen is submitted in entirety for frozen section. analysis.Summary of sections: 10AFSC, 1/1. 11) SOURCE: Lip Mucosal Margin The specimen labeled "lip mucosal margin" is received fresh on a cloth towel and consists of a segment of tan flat tissue measuring 3.8 x 0.2 x 0.2 cm segment. The sample is received with a mark denoting the inferior aspect of the sample; this area is inked in blue. The opposite end of the specimen has a focal black discoloration. The specimen is submitted in entirety for frozen section analysis.Summary of sections: 11AFSC, lip mucosa margin, 2/1 (sample separated during frozen section processing).. 12) SOURCE: Level 1A Neck Dissection The specimen labeled "level 1A neck dissection" is received fresh and consists of a 2.2 x 1.2 x 0.8 cm portion of lobulated fibroadipose tissue with two palpable lymph node candidates. The first is removed from the specimen that measures 0.2 x 0.2 x 0.2 cm. A second larger candidate lymph node is palpated measuring 1.1 x 0.6 x 0.2 cm. The remainder of the specimen is lobulated fibroadipose tissue. The specimen is submitted in entirety.Summary of sections: 12A, small candidate lymph node, 1; 12B, larger candidate lymph node #1, 1/1; 12C, remainder of tissue, 3/1. 13) SOURCE: Left Neck Level 2 The specimen labeled "left neck level 2" is received fresh and consists of a segment of lobulated fibroadipose tissue with candidate lymph nodes measuring 5.5 x 4.7 x 0.3 cm. The sample is examined revealing multiple candidate lymph nodes, the largest of which measures 3.1 x 1.1 x 0.6 cm. All candidate lymph nodes are submitted in entirety.Summary of sections: 13A, four distinct candidate lymph nodes, 4/1; 13B, two distinct candidate lymph nodes, 2/1; 13C-13D, sections of largest candidate lymph node, 13C, 4/1, 13D, 3/1; 13E, additional candidate lymph nodes (two) with representative sections of lobulated fibroadipose tissue.. 14) SOURCE: Left Neck Level 3 The specimen labeled "left neck level 3" is received fresh and consists of a segment of lobulated fibroadipose tissue with candidate lymph nodes measuring 6.3 x 4.3 x 0.3 cm. Numerous small candidate lymph nodes are identified, the largest of which measures 0.7 x 0.4 x 0.2. The majority of the specimen is submitted.Summary of sections: 14A-14C, candidate lymph nodes, 4/1 each; 14D, candidate lymph nodes with fibroadipose tissue, 4/1; 14E, representative section of fibroadipose tissue with possible lymph
+
+--- Page 8 ---
+nodes, 1/1. 15) SOURCE: Left Neck Level 4 The specimen labeled "left neck level 4" is received fresh and consists of a 6.0 x 4.5 x 0.3 cm segment of lobulated fibroadipose tissue with candidate lymph nodes. The largest identifiable candidate lymph node is 1.0 x 0.5 x 0.3 cm. Only one distinct candidate lymph node is identified. The specimen is submitted in entiretySummary of sections: 15A, candidate lymph nodes, 3/1; 15B-E, remainder of tissue, 15B, 2/1, 15C, 1/1, 15D, 2/1, 15E, 3/1. 16) SOURCE: Tongue, Jaw, Level 1B, Facial Skin and Buccal Mucosa The specimen labeled "tongue, jaw, level 1B facial skin and buccal mucosa' is received fresh and consists of an 8.0 cm from anterior to posterior, 7.0 cm from superior to inferior and 5.0 cm from medial to lateral resection including mandible, skin, salivary gland and buccal mucosa. Within the buccal mucosa, there is an ill-defined necrotic, red-tan ulcerating mass 4.2 x 3.5 x 0.8 cm. Along the superficial surface of the specimen, there is an attached 6.5 x 5.5 cm roughly ovoid excision of tan wrinkled skin. The specimen is marked with inked as follows: anterior-orange; posterior-black; medial-red; lateral-blue; superior-yellow; and inferior-green. The specimen is serially sectioned revealing the lesion to extend through the mandible towards the anterior skin surface, with a maximum of the tumor 2.8 cm. The lesion extends into the dermis and is 0.3 cm from the skin surface. Within the inferior aspect of the mandible, just overlying the salivary gland, there is a 1.8 cm in greatest dimension grossly positive lymph node candidate. Sectioning through the salivary gland reveals a normal lobulated surface with no discrete, grossly suspicious lesions identified. The lesion also extends into the muscular tissue and lies 0.5 cm from the red medial margin. The lesion is 0.7 cm from the anterior margin, 0.9 cm from the posterior margin, 1.2 cm from the blue inked lateral margin and greater than 3.0 cm from the nearest green inferior margin. No additional lymph node candidates are identified. Representative sections are submitted. A portion of tumor is submitted and placed in glutaraldehyde and within the -80 freezer on hold for possible future studies. Summary of sections: 16A, buccal mucosa and lesion upon approach to superior and anterior margins, 1/1; 16B, lesion and muscular tissue upon approach to medial and posterior margins, 2/1; 16C, nearest superior margin, 1/1; 16D, nearest medial margin, 2/1; 16E, salivary gland and portion of lymph node candidate, 1/1; 16F, skin upon approach to blue inked lateral margin, 1/1; 16G, skin and lesion upon approach to posterior margin, 1/1; 16H, lesion and skin upon approach to anterior margin, 1/1; 16I, lesion and vessel mucosa upon approach to superior margin, 1/1; 16J, lesion with posterior and superior margin, 1/1; 16K, positive lymph node candidate and salivary gland, 1/1; 16L, additional section of medial margin with lesion, 1/1; 16M, 16M, mandible with surrounding lesion, 1/1 each; 16O, anterior bone margin, 1/1; 16P, posterior bone margin, bisected, 2/1. Dictated by 4
+
+--- Page 9 ---
+Dictated by Slides and report reviewed by Attending Pathologist SURGICAL PATHOLOGY INTRAOPERATIVE CONSULTATION 1) SOURCE: Anterior Inferior Skin Margin FROZEN SECTION DIAGNOSIS: DYSPLASIA, NEGATIVE FOR TUMOR. 2) SOURCE: Anterior Superior Skin Margin FROZEN SECTION DIAGNOSIS: NEGATIVE FOR TUMOR 3) SOURCE: Posterior Inferior Skin Margin FROZEN SECTION DIAGNOSIS: NEGATIVE FOR TUMOR 4) SOURCE: Posterior Superior Skin Margin FROZEN SECTION DIAGNOSIS: NEGATIVE FOR TUMOR 5) SOURCE: Lingual Nerve FROZEN SECTION DIAGNOSIS: BENIGN. 6) SOURCE: Floor of Mouth Mucosal Margin FROZEN SECTION DIAGNOSIS: KERATOSIS AS DISCUSSED, NEGATIVE FOR HIGH GRADE DYSPLASIA. 7) SOURCE: Ventral Tongue Mucosal Margin FROZEN SECTION DIAGNOSIS: BENIGN. 8) SOURCE: Retromolar Trigone Mucosal Margin FROZEN SECTION DIAGNOSIS: BENIGN 9) SOURCE: Soft Palate Mucosal Margin FROZEN SECTION DIAGNOSIS: BENIGN 10) SOURCE: Buccal Mucosal Margin FROZEN SECTION DIAGNOSIS: BENIGN. 11) SOURCE: Lip Mucosal Margin FROZEN SECTION DIAGNOSIS: BENIGN.
+
+--- Page 10 ---
+Electronically signed by: The following special studies were performed on this case and the interpretation is incorporated in the diagnostic report above: 1xDECALCIFICATION In some tests, analyte specific reagents (ASRs) are used. In the case of an ASR, this test was developed and its performance characteristics. determined by this laboratory. It has not been cleared or approved by the US Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This test is used for clinical. purposes. It should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of (CLIA as qualified to perform high complexity clinical laboratory testing. ADDENDUM FINDINGS HPV analysis as performed by Reference Laboratories shows the tumor to be P16 negative by immunohistochemistry and HPV-16 negative by in-situ hybridization. Electronically signed by Slides and report reviewed by Attending Pathologist
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diff --git a/output/text/332695c1-5413-4847-86e5-6be31107d4a8.txt b/output/text/332695c1-5413-4847-86e5-6be31107d4a8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..dce789b9bdc8995280a904fe99022b7d1140a0d2
--- /dev/null
+++ b/output/text/332695c1-5413-4847-86e5-6be31107d4a8.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Specimen(s) Received 1. Oral-Cavity: portion maxilla 2. Oral-Cavity: deep mucosal margin . .... 3. Oral-Cavity: posterior margin. 4. Oral-Cavity: medial margin Diagnosis 1. Right maxillectomy.. - Squamous cell carcinoma, moderately differentiated.. a. Maximum tumour dimension: 2.2 cm.. b. Maximum tumour thickness: 0.8 cm.. c. The margins are negative for tumour (> 0.5 cm) d. No lymphovascular invasion or perineural invasion is identified. e. Bone sections are pending; an addendum will be issued.. 2. Deep mucosal margin biopsy.. - Negative for malignancy. 3. Posterior margin biopsy. - Negative for malignancy. 4. Medial margin biopsy. - Negative for malignancy. Synoptic Data Specimen Type: Resection:Right maxllectomy Tumor Site: Oral Cavity Histologic Type: Squamous cell carcinoma, conventional. Tumor Size: Greatest dimension: 2.2 cm Tumor thickness: 0.8 cm Histologic Grade:. G2: Moderately differentiated Venous/lymphatic (Large/Small Vessel) Invasion (V/L):. Absent Perineural Invasion:. Absent Additional Pathologic Findings:  None identified Margins: Margins uninvolved by tumor Page 1 of 3
+
+--- Page 2 ---
+Surgical Pathology Consultation Report. Pathologic Staging (pTNM): pTX: Primary tumor of lip or oral cavity cannot be assessed pNX: Regional lymph nodes cannot be assessed for aerodigestive sites pMX: Distant metastasis cannot be assessed Comment The T stage is deferred in the synoptic report as the bone is still pending decalcification. Gross Description 1. The specimen is labeled with the patient's name and as Oral Cavity: Portion maxilla. It consists of a portion of right maxilla measuring 5.0 AP x 2.0 Sl x 3.1 ML cm. It includes a portion of gingiva and roof of mouth/palate with four teeth. There is a tumor arising in the roof of mouth extending into the alveolar ridge going into the gingiva. The tumor measures 2.2 AP x 0.8 Sl x 2.1 ML cm. The tumor is solid in consistency and tan-brown in color. There is gross involvement of bone by the tumour. The tumor is located at 0.5 cm from the closest superior gingival margin. Remaining margins are as follows: Anterior gingival margin 2.3'cm; posterior gingival margin-1.1 cm; posterior palate margin-0.8 cm; medial palate margin 0.7 cm. Representative sections are submitted. 1A- superior gingival margin 1B- anterior gingival margin 1C- posterior gingival margin 1D- posterior palate margin 1E- medial palate margin 1F-1G- tumor 1H- normal gingiva and palate 11- anterior maxilla margin 1J- posterior maxilla margin 1K-1L- superior maxillary margin 1M- medial maxillary margin. 1N-1O- mid maxilla with tumor.. Three pieces of tumor/one piece normal were taken for tissue bank. 2. The specimen container is labeled with the patient's name and as "Oral Cavity: Deep mucosal margin". It consists of a fragment of tissue measuring 1.4 x 0.5 x 0.3 cm. 2A- specimen in toto. 3. The specimen container is labeled with the patient's name and as "Oral Cavity: Posterior margin'. It consists of a fragment of tissue measuring 0.9 x 0.3 x 0.2 cm.. 3A- specimen in toto. 4. The specimen container is labeled with the patient's name and as "Oral Cavity: Medial margin". It consists of a fragment of tissue measuring 0.6 x 0.3 x 0.2 cm. 4A- specimen in toto. Page 2 of 3
+
+--- Page 3 ---
+Surgical Pathology Consultation Report Addendum Comment 1. Maxilla (bone sections) - The tumour is present directly adjacent to bone but without invasion. - The maxillary bone margins are negative for tumour. - Tumour is present in the soft tissue adjacent to the superior bone margin.. - The tumour is staged as pT2 - tumour more than 2 cm but not more than 4 cm in greatest dimension. Page 3 of 3
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diff --git a/output/text/3326ccdc-abde-46d8-9ae8-4bf90b1e3039.txt b/output/text/3326ccdc-abde-46d8-9ae8-4bf90b1e3039.txt
new file mode 100644
index 0000000000000000000000000000000000000000..748fbf4ab0a5326d76c3075327724bd1a31ac817
--- /dev/null
+++ b/output/text/3326ccdc-abde-46d8-9ae8-4bf90b1e3039.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:5C732114-DD55-41D6-84C1-9BEDB7DF4345 TCGA-PK-A5HB-01A-PR Redacted LABORATORY MEDICINE PRC zuD-D-3 Carc inomo,adrenal cortica!. 8370/3 Site:(B Adrenal Cland,Cortex C 74.O J1//13 Surgical Pathology Consultation Report Patient Name: Accession #: MRN: Service: Collected: DOB: Visit #: Received: Gender: V Location: Reported: HCN: Facility: Ordering MD: Copy To: Specimen(s) Received 1. Spleen: spleenule 2. left spleen 3. Left adrenal distal pancreas, left kidney. Diagnosis 1. No pathological diagnosis: Accessory spleen; resection specimen.. 2. No pathological diagnosis: Spleen, splenectomy specimen.. 3. Adrenal cortical carcinoma, 12cm, 448 grams: Adrenal No pathological diagnosis: Kidney No pathological diagnosis: Pancreas. Nopathological diagnosis: Lymph nodes, 2. - Left adrenalectomy, nephrectomy, splenectomy, and distal pancreatectomy specimen.. Electronically verified by:. Clinical History None given. Gross Description 1. The specimen container labeled with the patient's name and as "splenule" contains a round grey-blue accessory spleen that measures 1.8 x 1.7 x 1.2 cm. On section the specimen is tan and grossly unremarkable.. 1A - specimen submitted in toto.. 2. The specimen container labeled with the patient's name and as "left spleen" contains an intact blue-grey spleen that measures 13.0 x 10.0 x 5.0 cm. The serosal surface and the cut surface are unremarkable. No nodes are identified in the hilar region. A piece of normal tissue is stored frozen. Representative sections are submitted as follows: 2A-D - four representative sections. 3. The specimen container labeled with the patient's name and as "left adrenal distal pancreas, left kidney" contains a  kidney adherent to a large adrenal mass and an adherent portion of pancreas. The specimen measures 14.5 x 19.0 x 12.0 cm. The kidney measures 11.5 x 6.5 x 6.0 cm and is grossly unremarkable. The pancreas measures 5.5 x 3.0 x 2.3 Page 1 of 2
+
+--- Page 2 ---
+Surgical Pathology Consultation Report . cm and is grossly unremarkable. The adrenal mass measures 12.0 x 8.5 x 9.5 cm and weighs 448 grams. Its cut surface is tan, partly solid, partiy friable, and lobulated with foci of hemorrhage. No obvious adrenal parenchyma is identified but small patches of bright orange-yellow are seen particularly in the capsular region. In the perirenal fat there are several nodes that range in size from 0.3 cm in diameter to 9.0 cm in diameter. A piece of adrenal tumor is stored frozen. Sections are submitted as follows: 3A-3C -sections of tumour with identifiable adrenal gland and adjacent kidney 3D-3G -tumour 3H - One section, one pole of kidney 31 - opposite pole of kidney 3J -  mid section of kidney 3K - three sections of margins of blood vessel at the hilar region of kidney 3L - resection margin of another vessel at the hilar region of the kidney 3M - resection*margin-ofsweter: 3N-3O -two representative sections of the pancreas 3P - one node bisected 3Q - one small node bisected 3R - one node bisected 3S-3U adrenal cortex with tumor 3V-3X peripheral part of tumor with capsule 3Y-3AB central part of tumor, probable necrotic 3AC-AD tumor with kidney Microscopic Description 1. Splenic tissue 2. Splenic tissue 3. Adrenal DOMINANT LESION: invasive adrenal tumor SIZE: 12 cm maximum dimension WEIGHT: 448 grams ARCHITECTURE: solid and trabecular architecture CYTOLOGY: clear and compact cells with marked nuclear pleomorphism and numerous mitoses; numerous multinucleated cells DEGENERATION: extensive geographic necrosis and broad fibrous bands ENCAPSULATION: thick capsule CAPSULAR INVASION: full thickness invasion present EXTRA-ADRENAL INVASION: tumor invades peri-adrenal fat RESECTION MARGINS: not involved LYMPHOVASCULAR INVOLVEMENT: not identified OTHER ADRENAL PATHOLOGY: none identified LYMPH NODES: two identified,  Kidney: no significant pathologic alterations; minimal glomerulosclerosis Pancreas: no significant pathologic alterations; discrete focal inflammation and fibrosis. Page 2 of 2
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diff --git a/output/text/337df060-d008-463a-9149-ceb25c330224.txt b/output/text/337df060-d008-463a-9149-ceb25c330224.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7a89a9e49dbf616662815fb523e8c9c4b2195d8e
--- /dev/null
+++ b/output/text/337df060-d008-463a-9149-ceb25c330224.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+tcD o3 Coreusne, N6s 56lcf3 Final Surgical Pathology Report Q 4/12/13 Procedure: Diagnosis A,B. Lymph nodes, left axillary sentinel #1 & #2, excisions - Negative for malignancy.. C. Breast, left, segmental mastectomy Invasive mammary carcinoma, no special type, high combined histologic. grade, high proliferative rate. D. Breast, left, posterior to segmental mastectomy, excision - Negative for malignancy. Note: The above diagnoses are rendered per expert consultation from of Please see the consultation report from Dr. In a comment, states: "This invasive carcinoma is c+rcumscribed and has an expansile rather then infiltrative growth pattern, which may explain the lack of nodal involvement. In an addendum comment, :ates: "The closest margin from the left segmental mastectomy (specimen c) is posterior (1.5 mm), however the separately submitted new posterior margin (specimen D) is negative. margins are negative by least 4 mm.  The other Microscopic Description: A,B,D. Microscopic examination performed.. C. The following template summarizes the findings in part C: Invasive Carcinoma: Present Histologic type: Invasive mammary carcinoma, no special type. Histologic grade: High combined histologic grade, high proliferative rate Greatest dimension (pT): 4.2 cm (pT2) Specimen margins: The margins are adequate (see comment in diagnosis) Vessel invasion: Not identified Calcification: Not identified Ductal carcinoma in situ: Not identified Comment: Please note that in addition to examining H&E stained sections, representative blocks in part C were immunostained with antibodies to p63 to aid in assessment.. Prognostic markers: Previously performed (see. {A few of the antibodies used in our laboratory may be classified as. analyte specific reagents. These antibodies are monitored and controlled in our laboratory and their performance for in vitro diagnosis is well described in the medical literature.  They have not been cleared or approved by the FDA.]. UUID:FA5CF5A2-F44A-4303-9200-32250FAEF374 TCGA-A7-A5ZV-01A-PR 'Redacted
+
+--- Page 2 ---
+Specimen A. Left axillary sentinel node #1, hot, not blue, 1018. B. Left axillary sentinel node #2, hot, blue, 237 C. Left breast segmental mastectomy D. Tissue posterior.to segmental mastectomy Clinical Information. PRE-OP DIAGNOSIS: Left breast CA Gross Description. A. Received fresh in a container labeled "left axillary sentinel node #1, hot, not blue, 1018" is a 2.2 x 1.7 x 1 cm soft tan-pink lymph node with some surrounding yellow adipose tissue. As-4, following fixation. B. Received fresh in a container labeled "left axillary sentinel node #2, hot, blue, 237" is a 2.5 x 2.2 x 1.2 cm portion of tissue. adipose tissue, with the lymph nodes 1 and 1.5 cm in greatest dimension.  Rs-4, following fixation, with the lymph nodes entirely. submitted, with the larger lymph node in blocks b2-b4.. container labeled "left breast C. Received fresh in a. segmental mastectomy" is a 7.3 x 5.7 x 4.3 cm portion of soft.  The margins tan-yellow breast tissue, with orienting sutures present. are inked as follows based upon the sutures: anterior - green;. - red; inferior - blue;. posterior - black; lateral - orange; medial - superior - violet. The specimen is serially sectioned revealing a 4.2 x. 4.2 x 3.5 cm red-brown to white-tan nodular mass, which grossly comes RS-10, following fixation, with tumor to closest medial margin in block cl, tumor to closest lateral margin in block c2, tumor to closest anterior margin in block c3, tumor to closest posterior margin in block c4, tumor to closest superior margin in block c5, tumor to closest inferior margin in block c6, and with additional sections of tumor in blocks c7-cio. D. Received fresh in a container labeled "tissue posterior to segmental mastectomy" is a 1.7 x 1.2 x 1.2 cm portion of soft red-brown skeletal muscle, with a suture indicating the new posterior border. The new margin is inked..  The specimen is sectioned and is without focal lesion. As-3, following fixation. h 3[ish3
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diff --git a/output/text/338174ef-4f5f-4e33-8360-2748656d86ad.txt b/output/text/338174ef-4f5f-4e33-8360-2748656d86ad.txt
new file mode 100644
index 0000000000000000000000000000000000000000..82dcc91ce3588d8dcc6bd4ffb0a79c96c94b72a6
--- /dev/null
+++ b/output/text/338174ef-4f5f-4e33-8360-2748656d86ad.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:030DC904-C959-4D06-AE70-C99AFAAB31E0 TCGA-KM-A7QH-01C-PR Redacted MEDICAL RECORD Surgical Pathology Report. Surgical Pathology Report. PATIENT: MRN: ACCOUNT#: RECEIVED DATE: DOB: PROCEDURE DATE: AGE: SEX: M SIGN-OUT DATE: ATTENDING: LOCATION: REQUESTING: RoOM: CONTACT NO: COpIes TO: sremomo DIAGNOSIS: Site: B Yedney NoS C64.9 I4/24/13 1. Kidney, right (specimens 1&2, excision): Renal cell carcinoma with chromophobe features, Fuhrman nuclear Grade II/IV. 2. Rib (biopsy): A piece of unremarkable rib, gross diagnosis only. CLINICAL INFORMATION: HISTORY: MAN WiTH BHD PROCEDURE: PREOP DX:#SOLID RENAL MASS POSTOP DX: SOLID RENAL MASS OPERATIVE FINDINGS: 3 CM SOLiD MASS IN MID POLE OF RIGHT KIDNEY AND .5 CM MASS iN POSTERIOR ASPECT OF RIGHT KIDNEY SPECIMENS SUBMITTED:A 1) KIDNEY, RIGHT 2) KiDNEY, RIGHT 3) RIB GROss DEscRIPTiON: Received are three (3) containers labeled with the patient's name and number. 1. *Solid" contains a single fragment of yellow-white soft tissue measuring 0.9 X 0.7 X 0.5 cm.. The fragment of tissue has been previously incised and has a gold-mahogany cut surface. A portion is retained in and the remainder is submitted in cassettes labeled 1A and 1B. 2. *Solid #2" contains a single fragment of soft, red-tan-gold soft tissue measuring 4.2 X 3.5 X 2.5 cm. overall. The specimen represents a solitary mass measuring 2.8 X 3.5 X 2.5 cm. with attached fibroadipose tissue in grossly-appearing normal kidney. The specimen has been previously incised and reveals a red, friable cut surface with areas of aold-tan tissue. No discernable capsule is appreciated. Representative portions are retained in and representative portions are submitted in cassettes 2A-2F. Patient Identification Page 1
+
+--- Page 2 ---
+MEDICAL RECORD Surgical Pathology Report 3. *Right rib" consists of a single fragment of tissue, consistent with rib with minimal sott tissue measuring 1.0 X 0.5 X 7.0 cm. The specimen is submitted for gross diagnosis only.. Printed  Patient Identification
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diff --git a/output/text/33c5fed2-1295-4dc6-86f9-8da96c4721e2.txt b/output/text/33c5fed2-1295-4dc6-86f9-8da96c4721e2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..274d873d99ba6c3ca563ad2b34da573b936e4d2d
--- /dev/null
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+
+--- Page 1 ---
+Clinical Diagnosis & History: female with right renal mass. For right radical nephrectomy. Specimens Submitted: 1: SP: Right kidney. 2: SP: Paracaval lymph node 3: SP: Right adrenal DIAGNOSIS: 1) KIDNEY, RIGHT; RADICAL NEPHRECTOMY: - RENAL CELL CARCINOMA, CHROMOPHOBE TYPE. - THE PATTERN OF GROWTH IS ACINAR AND SOLID - THE TUMOR GREATEST DIAMETER IS 10.0 CM. - THE TUMOR EXTENDS INTO THE RENAL PELVIS. - NO INVASION OF THE RENAL VEIN IS IDENTIFIED. - ALL SURGICAL MARGINS ARE FREE OF TUMOR - THE NON-NEOPLASTIC KIDNEY SHOWS FOCAL GLOMERULOSCLEROSIS 2) LYMPH NODE, PARACAVAL; BIOPSY: - FIFTEEN BENIGN LYMPH NODES (O/15) 3) ADRENAL GLAND, RIGHT; RESECTION: - ADRENOCORTICAL ADENOMA, MEASURING 0.9 X 0.8 X 0.7 CM. IATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Special Studies: Result Special Stain Comment A103 INH CD10 RCC NEG CONT IMMRECUT Page 1 of 3
+
+--- Page 2 ---
+1)  The specimen is received fresh, labeled "Right Kidney".  It consists of a kidney with attached perinephric fat, weighing 510 grams and measuring 13 x 10 x 7.5 cm. A portion of ureter is identified measuring 6 cm in length x 0.3 cm in diameter.The. ureter is serially sectioned revealing a grossly unremarkable cut surface.. Vessels are identified on the hilum, ranging in size from. 0.5 to 0.7 cm in length with a diameter measuring 0.2 cm. The kidney is partially covered by a thick portion of perinephric fat which measures 15 x 6 x 0.7 cm. The kidney is bisected revealing a large, yellow-tan, focally hemorrhagic, partially necrotic, variegated tumor mass located predominantly on the upper two-thirds of the kidney, involving the renal cortex, medulla and pelvis, entirely measuring 10 x 9.5 x 9 cm.  The tumor appears grossly to be confined within the renal capsule. The tumor is serially sectioned, revealing a yellow-tan to red-gray, hemorrhagic and friable cut surface.  On the center of the tumor is a more. well-circumscribed, markedly hemorrhagic area measuring 4 x 4 x 2 cm.  A small portion of residual normal renal parenchyma is. identified. Photographs are taken.  Representative sections are submitted.  A section from the tumor is submitted for TPS and EM. Summary of Sections: UM - ureter margin RV - renal vessel PF - perinephric fat NK - normal kidney PEL -- pelvis T  tumor  AG -- additional perinephric fat HAT - hemorrhagic area of the tumor 2) The specimen is received in formalin, labeled "Paracaval Lymph Node". It consists of multiple irregular fragments of yellow-tan, lobulated adipose tissue measuring in aggregate 5.5 x 3 x 2 cm. Twelve lymph nodes are identified, ranging in size from 0.3 to 1.7 cm.The entire lymph nodes are submitted.The two largest lymph nodes are bisected and placed in the first two. cassettes. Summary of Sections: PCN -- paracaval lymph nodes (2pcn2-bisected large lymph node and one smaller lymph node) 3) The specimen is received in formalin, labeled "Right Adrenal".  It consists of an adrenal gland with one edge closed by  multiple staples, entirely measuring 5.5 x 2.5 x 1.8 cm.The resection margin is inked black. The specimen is serially sectioned revealing a well-circumscribed, tan-yellow, soft nodule measuring 0.9 x 0.8 x 0.7 cm.The rest of the adrenal gland appears. grossly unremarkable. The specimen is entirely submitted. Summary of Sections: ADG -- adrenal gland SM - stapled margin Summary of Sections: Part 1: SP: Right kidney (am) Block Sect. Site PCs 2 AG 3 3 HAT 4 2 NK 4 2 PEL 4 2 PF 3 1 RV 4 6 T 7 1 UM 1 Part2 SP: Paracaval lymph node (pjm) Block Sect. Site PCs  Page 2 of 3
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diff --git a/output/text/33ed75c2-97ae-4921-8293-f3e65fb9ddc5.txt b/output/text/33ed75c2-97ae-4921-8293-f3e65fb9ddc5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..21f061b6487525f0b32bd1a17faabeaea7a68027
--- /dev/null
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+
+--- Page 1 ---
+Department of Patholoay SURGICAL PATHOLOGY REPORT * Preliminary * Patient Name: Path No.: Med. Rec. #: Client: DOB/Gender: Collected: Location: Received: Soc. Sec. #: Reported: Hosp #: Physician(s): Pre-Operative/Clinical History Nonfunctioning left kidney. Specimen(s) Received A: TORSED APPENDAGE EPIPLOICA B: PERIHILAR RENAL LYMPH.NODE C: LEFT KIDNEY Gross Description Specimen A, received in formalin labeled torsed appendage epiploica, consists of a hemorrhagic firm portion of adipose tissue measuring 2.8 x 1.5 x 0.5 cm. The cut surface is tan-brown. Representative sections are submitted. Specimen B, received in formalin labeled perihilar renal lymph node, consists of a 1.7 x 1.3 x 0.8 cm portion of a lymph node. The cut surface is homogenous tan-pink. The node is sectioned and entirely submitted labeled Specimen C, received fresh from the OR labeled left kidney, consists of the following: Procedure/specimen type: Radical nephrectomy.. Specimen laterality:. Left. Description of specimen: The 726 gm kidney with associated perinephric fat measures overall 19.0 x 14.0 x 7.0 cm. Gerota's fascia is hemorrhagic with fibrous adhesions. Gerota's fascia is fibrotic and thickened measuring up to 0.5 cm. The perinephric fat is firm and lobulated measuring up to 2.0 cm in thickness. Blue ink is applied to Gerota's fascia and the mass grossly appears to abut the fascia. The attached segment of ureter measures 4.0 cm in length with an internal diameter of 0.3 cm and is grossly unremarkable and not involved by the tumor. The kidney measures 12.0 x 6.5 x 5.5 cm. The kidney is surrounded by a large cystic hemorrhagic mass containing.blood clot. The mass is attached to the kidney and grossly involves the renal parenchyma superiorly. Sections show a soft tan expansile solid area within the cystic mass abutting the surface of the kidney and slightly compressing the  renal parenchyma. The renal pelvis is slightly displaced. The corticomedullary junction within the superior pole of the kidney is pale white-pink and compressed. Within the superior pole of the. kidney is a portion of attached adrenal gland measuring 3.0 x 3.0 x 0.3 cm. The adrenal  parenchyma shows thin brown medulla with focally thickened golden yellow cortex. The portion of adrenal gland is markedly adherent to the surface of the kidney and gross involvement by tumor cannot be definitively determined.. Page'1 of 4
+
+--- Page 2 ---
+HISTOLOGY REPORT Adrenal gland: Also received within the specimen container is a separate portion of adrena! gland measuring 5.0 x 2.2 x 1.5 cm and weighing 8 gm. The cut surface shows thin golden yellow cortices with brown medulla. The adrenal gland grossly does not appear to be involved by the tumor. Tumor site: Supracortical, with the solid component predominantly involving the superior pole of the kidney and the cystic component involving the remainder of the external kidney. Tumor size: The cystic component measures 19 cm in greatest dimension and the solid component. measures 5.0 cm in greatest dimension. Tumor description: The cystic mass involves the renal capsule with possible focal extension into the renal parenchyma. Within the cystic mass is a moderate amount of blood clot. The luminal surface of the mass is focally nodular: The cystic mass wall ranges from 0.1 cm to 0.6 cm in thickness. A representative section is submitted for frozen section Focality: Unifocal. Extent of invasion:. The tumor involves the renal capsule with foci suspicious for infiltration into renal parenchyma. Renal vessel involvement: Absent. Renal hilum: Uninvolved by tumor. Perinephric Iymph nodes: A single perinephric lymph node measuring 2.0 x 1.3 x 1.0 cm which grossly is uninvolved by the tumor is present. Rena! parenchymal lesions:.  None identified. Gross photos are taken. Representative sections are submitted as follows: (C1FS) Remainder of the frozen tissue. (C2) Ureteral margin, en face (C3) Renal artery and vein margin, en face (C4, 5) Gerota's fascia, perpendicular sections showing proximity of tumor (C6, 7) Adrenal gland and underlying tumor (C8) Separate portion of adrenal gland (C9) Renal hilum (C10) Renal lymph node, sectioned (C11-18) Kidney with adjacent tumor with guestionable areas of renal parenchymal involvement in (C11-13) (C19-25) Cystic mass wall (C26) Renal pelvic mucosa (C27) Superior calyceal mucosa (C28) Inferior calyceal mucosa (C29) Superior renal parenchyma (C30)  Inferior renal parenchyma. Intraoperative Consultation Specimen C, frozen section diagnosis of "carcinoma' is rendered by Page 2 of 4
+
+--- Page 3 ---
+HISTOLOGY REPORT Microscopic Description Summary of Pathologic Findings Renal Carcinoma Operative procedure: Radical nephrectomy. Tumor size: The cystic component of the tumor is 19.0 cm in greatest dimension with. a solid component of 5.0 cm in greatest dimension.. Laterality and focality: Left and unifocal. Histologic type: Papillary renal cell carcinoma Sarcomatoid features: Absent.  Histologic grade: Fuhrman 3/4. Extent of invasion: Extracapsular invasion into the perinephric tissue, not beyond Gerota's fascia. Lymph/vascular invasion: Absent. Margins: Radical nephrectomy margins: Renal vein margin: Negative. Gerota's fascial margin:. Negative. Ureteral margin: Negative. Adrenal gland: Not involved. Regional lymph nodes: Number of nodes examined:. 2. (includes specimen A) Number of nodes positive for tumor: 0.. Special studies: A panel of immunohistochemical stains is performed to delineate the immunophenotype of this. tumor. The following staining patter is observed:. CD10 Negative P504S Positive Vimentin Positive CK7 Negative Low molecular weight keratin Positive Mart-1  Negative HMB-45  Negative CD117  Negative N-cadherin Positive TFE3 pTNM stage: pT2b, pN0. The submitted epiploica (B) demonstrates infarction consistent with the clinical impression of torsion. There is no evidence of tumor. Page 3 of 4
+
+--- Page 4 ---
+HISTOLOgy rEPORT A perihilar lymph node (A) is submitted which demonstrates follicular hyperplasia as does the node attached to the kidney. Pathologic findings in nonneoplastic kidney: Interstitial nephritis. Diagnosis TORSED APPENDAGE EPIPLOICA, RESECTION : INFARCTED EPIPLOICA. PERIHILAR RENAL LYMPH NODE, RESECTION: FOLLICULAR HYPERPLASIA. LEFT-KIDNEY, RADICAL NEPHRECTOMY: PAPILLARY RENAL CELL CARCINOMA, FUHRMAN GRADE 3/4 ONE LYMPH NODE NEGATIVE FOR TUMOR. ADRENAL GLAND NEGATIVE FOR TUMOR Intradepartmental Consult. Comment Positive and negative controls react satisfactorily. FDA required disclaimer: These tests were developed and their performance characteristics determined by They have not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approva! is not necessary. These tests are used for clinical purposes and should not be regarded as investigational or for research. This laboratory is certified under the Clinical Improvement. Amendments of (CLiA) as qualified to perform high complexity clinical laboratory testing.  required information for predictive/prognostic markers: 1. Type of specimen fixation and detection system: Tissue is fixed in 10% formalin. Indirect biotin-free detection kit is used. Clones used: ER (clone  Novocastra; PR (clone DakoCytomation; CD117 (polvclonal, DakoCytomation); HER2 (clone Ventana, FDA approved); Ki-67 (clone Cell Marque) p53 (clone  Novocastra), MSH6 (clone Biocare), MSH2 (CellMarque clone. , MLH1 (Cell Margue clone , PMS2 (clone) Cell Marque). 3.Criteria for positive results:  ER and PR: 1% of tumor cells with nuclear staining; HER2: >30% of cells show complete membrane. staining; p53: 10% of tumor cells with nuclear staining; MMR Proteins: complete absence of tumor nuclear staining.. CPT Code(s) A: 88305 B: 88305 C: 88331, 88307, 88342, 88342, 88342, 88342, 88342, 88342, 88342, 88342, 88342, IHC S/O(3) END OF REPORT Page 4 of 4
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diff --git a/output/text/3423c242-295e-47e1-b86e-e01a04f18eee.txt b/output/text/3423c242-295e-47e1-b86e-e01a04f18eee.txt
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index 0000000000000000000000000000000000000000..fdd9246494c389a201a5ea0f196bf3b55efc215d
--- /dev/null
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+
+--- Page 1 ---
+Date Printed: UUID:887CA21D-BC50-446A-B804-98147E5604AA Redacted Date Collected : TCGA-TS-A7P0-01A-PR Date Received: * /ears Sex: Male Accession No Physician: Copy to: SsrgicalPalhoogyaepo ICD O-3 9s52/3 Site srai NOS Clinical Information C38.4 year old male patient presents for radical pleurectomy and PDT for mesothelioma.. 9/24/)3 Final Diagnosis 1. previous Incision site, frozen section: Skin and underlying soft tissue with changes ot previous biopsy site and scar formation, no tumor seen. 2. RIB: Benign lamellar bone with trilinear bone marrow formation and surrounding soft tissue with foreign body type giant cell formation consistent with close previous biopsy site. 3. PARIETAL PLEURA, FROZEN SECTION: Dense tibrocollagenous soft tissue with focal chronic and acute intlammation. No tumor seen. 4. PARIETAL PLEURA: Fragments of tibrotatty sot tissue with focal mesothelial lining. No tumor seen. 5.LEVEL 6: Sections of lymph node, no tumor seen. 6. PERICARDIAL FAT: Fibrofatty soft tissue with mesothelial lining with tocal areas of significant increased proliferation of mesothelial cells, suspicious of tocal involvement by mesothelioma. 7.LEVEL5: Sections of lymph node, no tumor seen. 8. APICAL CHEST MASS, FROZEN SECTION: Tumor nodule with presence of malignant mesothelioma, epithelioid type. The tumor is present within tne lung parenchyma and shows a focal presence of a pseudo capsule... In other areas the tumor nodules are invading directly into alveolar lung parenchyma.. No tumor seen at stapeled resection margin of speclmen. Tumor Is positive for calretinin, CK7, D2-40 (focal),CK5/6 (focal), AE1-3 and negative for CD15, TTF1, CEA, MOC31 and WT1 consistent with the diagnosis ot mesothelioma 9. PERIPHRENIC TISSUE: Fibrotatty soft tissue with superticial mesothelial lining. Name Page 1 of 6 MRN
+
+--- Page 2 ---
+Name: Date Printed: MRN: Date Collected Date Received; DOB: years Sex: Male Accession No: ! Age: Loc..  Physician: Copy to: S07g1caRa00l0gy8Bp0l The mesothelial lining, shows, in areas, prominent proliferation and pleomorphism suspicious of focal involvement by malignant mesothelioma. Prominent toreign body type giant cells identified. 10. LEVEL 9: Fragments ot fibrofatty soft tissue, no tumor seen. Section of small lymph node, no tumor seen.. 11. POSTeRIOR INTERCOSTAL: Sections of lymph node, no tumor seen. 12. VISCERAL PLEURA: Sections of fibrous soit tissue with mesothelial lining and prominent giant cell formation.. The mesothelium is, in areas, prominently proliferative with pleomorphic changes suspicious for tocal involvement with mesothelioma. 13.LEVEL 8: Sections of lymph node, no tumor seen. 14. LEVEL 7: Sections of lymph node, no tumor seen. Fibrotatty soft tissue with accumulation ot mesothelial cells not diagnostic for malignant tumor.. 15. VISCERAL PLEURA (STITCH MARKS NODULE): Sections of visceral pleura with prominent foreign body type giant cells and lined by mesothelium witn focal prominent prolifteration of mesothelium.. No detinite tumor seen. 16. PHRENIC NODE: Sections of lymph node, no tumor seen.. 17. PERICARDIAL TISSUE: Sott tissue with presence of mesothelioma.. 18. DIAPHRAGMATIC PLEURA: Fibrotatty sot tissue with focal mesothelial tining and focal mesothelial hyperplasia, no detinite tumor seen.. Name: Page 2 of 6 MRN: 
+
+--- Page 3 ---
+Name Date Printed: MRN: Date Collected Date Recelved: DOB:  Age: years Sex: Male Accession No: Loc.: Physician: Fried Copy to: SurgicalpaboogyBopon Selective slides reviewed with The case material was reviewed and the report verified by: :. (Electronic signature) Verification Date: Note Disclaimer: The above in-vitro IHC tests may have used reagents labeled for IVD (In Vitro Diagnostic Use), IUO (Investigational Use Only) and/or RUO (Research Use Only) and have not been cleared or approved by the U.S Food and Drug Administration. However, the FDA has determined that such clearance or approval is nat necessary for ASR class I tests intended to provide pathologists with adjunctive information to assist their morphologic ovaluation. The tests using IUO or IUO reagents were develooed and their performance characteristics were validated for diagnostic use by the . This laboratory is regulated under the Clinical Laboratory Improvement Amendments of 1988 (CLIA) as qualitied to pertorm high complexity. clinical tests. These Class I ASR tests are not intended to provide diagnostic, prognostic, predictive or therapeutic information that is not directly confirmed by routine histopathologic intenal or extenal control specimens. Frozen Sectlon Dlagnosis F$-1: Incision site: Skin and scar, no tumor seen.. FS-2: Parietal pleura: Fibrous tissue with surrounding reactive and atypical mesothelial cell proliteration. No detinite invasive pattern seen. (Seen with F$-3: Chest mass: No detinite tumor seen at lung margin of specimen.. Gross Description The specimens are received in eighteen parts labeled with the patient's name and medical record number. Specimen #1 is received fresh tor frozen section and labeled "previous incision site*. The specimen. consists of a 10.4 x 1.2 cm skin ellipse excised to a depth of 1.6 cm. The skin surface is tan grey,. wrinkled and displays an Ill defined linear scar which surtaces the entire lengtn of tne specimen.. Representative sections are submitted for trozen section and the frozen section control is submitted In cassette 1A. Additional representative sections are submitted in cassette 1B.. Name... Page 3 of 6 MRN:
+
+--- Page 4 ---
+Name: Date Printed: MRN:  Date Collected Date Received DOB Ace: years Sex: Male Accession No Loc.: Physician: Copy to: S0rgicapahoogyBoporn Spscimen #2 is received in tormalin and labeled *rib'. The specimen consists of three cylindrical portions of tirm and trabeculated bone ranging from 5.6 cm to 6.0 cm in length and averaging 1.5 cm in greatest dimension. Sectioning revea!s grossly unremarkable cut surfaces. No discrete masses or lesions are grossly identitied. A representative section is submitted in cassette 2A following decalcification. Specimen #3 is received fresh tor frozen section and labeled *parietal pleura". The specimen consists of a 1.1 x 0.6 x 0.3 cm irregular fragment ot tan white to tan yellow, rubbery soft tissue which is submitted in toto in cassette 3A. Specimen #4 is received in formalin and labeled "parietal pleura'. The specimen consists ot a 7.2 x 5.4 x 2.5 cm aggregate of multiple irregular and ragged fragments of grey purple to tan yellow, wrinkled soft tissue. Focal areas ot muscle are identified. The outer surtaces are grossly unremarkable with no discrete masses or nodules identified. Representative sections of muscle are submitted in cassette 4A. Representative sections from the remainder of the specimen are submitted in cassettes 48 through 4D. Specimen #5 is received in tormalin and labeled *Level 6'. The specimen consists ot two tan grey to yellow tan, nodular soft tissue fragments measuring 0.6 cm and 1.0 cm in greatest dimension. The specimen is submitted in toto in cassette 5A. Specimen #6 is received in formalin and labeled *pericardial tat. The specimen consists of four irregular fragments of tan yellow to grey purple, coarsely lobulated adipose tissue ranging trom 2.4 cm to 6.5 cm in greatest dimension. Sectioning reveals two indurated, tocally nodular areas measuring 0.5 cm and 0.6. cm in greatest dimension. The remaining cut surtaces are tan yellow and grossly unremarkable. The nodular areas are submitted entirely in cassette 6A. Representative sections trom the remainder ot the specimen are submitted in cassette 63.. Specimen #7 is received in formalin and labeled *"Level 5*. The specimen consists of a 2.8 x. 2.4 x 1.0 cm nodular and indurated soft tissue fragment which is bisected and submitted entirely in cassettes 7A and 73. Specimen #8 is received tresh for trozen section and labeled "apical chest mass*. The specimen consists of an 83 gram (following formalin tixation), 7.5 x 6.9 x 4.5 cm nodular soft tissue tragment which displays a 9.5 cm in length staple line along one aspect of the specimen. The specimen is incised at time of trozen section to reveal a 6.6 x 6.5 x 4.5 cm tan white, firm nodule which grossly abuts the visceral pleura. On one aspect of the nodule, there is a 5.5 x 4.5 x 1.5 cm focus of red brown, grossly unremarkable lung parenchyma attached.. The tissue adjacent to the stapled resection margin is submitted for frozen section and additional representative sections are submitted as follows: Block 8A Frozen section control Block 88 True resection margin Blocks 8C,8D Representative mass Block 8E Mass in relation to uninvolved lung parenchyma Nar Page 4 of 6 MR
+
+--- Page 5 ---
+Name Date Printed: MRN Date Collected Date Received: DOR Age: years Sex: Male Acxession No:1 Loc.:  Physician Copy to: Surg1capaboogyBep0r Specirnen #9 is received in formalln and labeled *periphrenic tissue". The specimen consists ot two irregular and ragged tragments ot grey purple to tan yellow, coarsely lobulated sott tissue measuring 7.9 cm and 16.8 cm in greatest dimension. Sectioning reveals grey purple to tan white, focally dense and fibrous cut surfaces with a large amount of yellow tan, coarsely lobulated adipose tissue. No discrete masses or nodules are grossly identified.. Reoresentative sections are submitted in cassettes 9A through 9C Specimen #10 is received in formalin and labeled "Lovel 9. The specimen consists ot a 0.8 x 0.6 x 0.5 cm tan grey to tan yellow, nodular soft tissue fragment which is submitted in toto in cassette 10A. Specimen #11 is received in formalin and labeled *posterior intercostal". The specimen consists of a 1.2 x 1.0 x 0.5 cm tan yellow nodular soft tissue fragment which is submitted in toto in cassette 11A. Specimen #12 is received in tormalin and labeled "visceral pleura". The specimen consists of two irregular and ragged fragments ot grey purpie, wrinkled soft tissue tissue. One of the fragments displays a 1.0 cm in greatest dimension indurated focus which is sectioned to reveal tan white to tan yellow, firm cut surfaces. The remaining fragments display a 0.7 crn stellate tan white focus of tissue. No other discrete masses or nodules are identified. The indurated nodular areas are submitted in cassettes 12A and 12B. Additional representative section is submitted in 12C Specimen #13 is received in formalin and labeled "Level 8'. The specimen consists of a 0.9 x 0.8 x 0.5 cm tan grey, nodular soft tissue fragment which is submitted in toto in cassette 13A. Specimen #14 is received in formalin and labeled "Level 7". The specimen consists of two grey tan to tan yellow, nodular. soft tissue fragments measuring 1.0 cm and 1.1 cm in greatest dimension. The specirnen is submitted in toto in one cassette labeled 14A. Specimen #15 is received in formalin and labeled "visceral pleura, stitch marks nodule'. The specimen consists ot a 9.5 x. the surgeon with a stitch denoting a 0.5 cm in greatest dimension tan white, indurated nodule. The remaining cut surfaces are grossly unremarkable with no discrete masses or lesions identitied. On one aspect of the specimen is a 2.0 cm in greatest dimenslon focus of red brown, spongy possible lung parenchyma. The nodular area is submitted entirely in one cassette labeled 15A. Additional representative sections of the remainder of specimen submitted in cassettes 153 and 15C.. Specimen #16 is received in formalin and labeled "phrenic node'. The specimen consists of two yellow tan, nodular soft. tissue fragments measuring 1.0 cm and 1.2 cm in greatest dimension.The largest fragment is bisected and the specimen is submitted entirely in cassette 16A. Nam Page 5 of 6 MRN:
+
+--- Page 6 ---
+Name: Date Printed: MRN: Date Collected : Date Received: DOB:  PAge: years Sex: Male Accession No Loc.: Physician: Copy to: SogcapahologyBopo Specimen #17 is received in formalin and labeled "pericardial tissue'. The specimen consists of four irregular tragments ol grey purple, wrinkled soft tissue ranging from 0.3 cm to 1.3 cm in greatest dimension.. The specimen is submitted in toto in cassette 17A. Specimen #18 Is received in formalin and labeled *diaphragmatic pleura'. The specimen consists ot a 9.0 x 2.2 x 0.8 cm ragged and irregular strip of grey purple, wrinkled soft tissue which displays a 1.0 cm in greatest dimension area of induration which is sectioned to reveal tan white, dense cut surfaces.. The area of induration is submitted entirety in cassette 18A.. Additional representative sections are submitted in cassette 18B.. Dictated by: Pathologist(s) Name: Page 6 of 6 MRN:
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+
+--- Page 1 ---
+JUID: 6C698240 7-4F96-BF56-6079269392010 TCGA-E9-A5UO-01A-PR Redacted Gross Description: There is a quadrant of the breast with tumor up to 3.5 x 3 cm in size. Lymph nodes are soft hyperemic. Microscopic Description: Mucinous adenocarcinoma of the breast, G-2. Ten examined lymph nodes demonstrated sinus histiocytosis. Diagnosis Details: Tumor Features: Indeterminate, Tumor Extent: T2 tumor size more than 2cm not more than 5 cm, Venous Invasion: Absent, Margins: Absent, Treatment Effect: rcD 6 3 Comments: Adeuscarcinsme, mucinous NsS Formatted Path Reports: BREAST TISSUE CHECKLIST 8480/3 Specimen type: Partial mastectomy Site RBreas+ Nos C56.9 Specimen size: Not specified Jt2/9/13 Tumor site: Breast Tumor size: 3 x 0 x 3.5 cm Grossly evident lesion: Yes Histologic type: Adenocarcinoma, mucinous type Histologic grade: Moderately differentiated Tumor extent: Not specified Lymph nodes: 0/10 positive for metastasis (Axillary 0/10) Extracapsular invasion of the lymph nodes: Not specified Margins: Not specified Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined
+
+--- Page 2 ---
+Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified. Comments: Right w2113
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diff --git a/output/text/345dd863-4e00-4779-ab4b-6beba8911d01.txt b/output/text/345dd863-4e00-4779-ab4b-6beba8911d01.txt
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index 0000000000000000000000000000000000000000..94fe6bc5c29642708f2b2527485e2a8fba7b0be9
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+
+--- Page 1 ---
+UUID:0BF7CB67-49F1-42EA-8B41-9888D7E0DE61 Redacted Final Diagnosis Breast, left, wide local excision: Infiltrating ductal carcinoma, Nottingham grade II (of IIl), forming a 1.5 x 1.4 x 1.2 cm mass. (AJCC pT1c). Associated ductal carcinoma in situ, intermediate nuclear grade, compromises approximately 20% of the tumor. Resection margins are free of tumor. Separately submitted lateral, deep, inferior and superior margins are free of tumor.. Lymph nodes, left axillary sentinel Nos. 1, 2, and 3, excision: Multiple (3) left axillary sentinel lymph nodes without blue dye are negative for tumor. [AJCCpNO(i-)] Immunohistochemical cytokeratin stain was performed on the paraffin embedded sentinel lymph node tissue and confirms the H&E impression. 1cs-0-3 Carunomr. hfiltnntmg olect, Nos85oo/3 Sih: busst, nos c50.9
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diff --git a/output/text/34611969-118d-4d77-883a-f5e20c3e3f64.txt b/output/text/34611969-118d-4d77-883a-f5e20c3e3f64.txt
new file mode 100644
index 0000000000000000000000000000000000000000..296d7dd616762b87bf09fbccf95a3eb8dd253040
--- /dev/null
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@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+DOB Age Gender:F Ref#: Hosp# Provider Group: Date of Service: Date Received: Case #: Room Bed: Date Reported: FINAL SURGICAL PATHOLOGYREPORT Diagnosis: A.&B.)PORTION OF KIDNEY,RESECTION: -RENAL CELL CARCINOMA,PAPILLARYVARIANT, TYPEI. -Tumor measures 3.0 cm in greatest dimension. -MARGINS:NEGATIVE. -LYMPH NODES:NONE IDENTIFIED -SEE COMMENTS PATHOLOGIC TUMORSTAGING DESCRIPTORS: Histologic type and grade: Renal cell carcinoma, papillary variant, type l. Primary tumor:pT1a. Regional Iymph nodes:pNX Distant metastasis:pMX. Margin status:RO. Pathologic stage:I. Lymphovascular invasion:Not identified. Perineural invasion:Not identified. COMMENT: Immunohistochemical staining is positive for OSCAR-CK, CK7, racemase, and CD10.It is negative for CK20 and CD117. This supports the given diagnosis. COMMENT:Tumor extends to the parenchymal edge of specimen A. From pathologic examination alone, it is not possible to determine with certainty whether or not the portions of the parenchymal edge of specimen A which are involved by tumor are true margins or only "specimen margins" in which specimen B is the true surgical margin. Specimen B is negative for malignancy. Additionally,a substantial portion of tumor is less than 0.1cm from the parenchymal edge of specimen A; this area appears significantly larger than the aggregate size of all the tissue inspecimen B. The margin. status in this report was given following telephone conversation with who stated that the pertinent specimen for establishing the margin in question (parenchymal margin) is specimen B. Kidney Tumor Staging Information Case #: Page 1 Printed: This report continues... (FINAL) MR No. Acct No. Patient Name Pathology Report -Page 1/4 Page1 Doc
+
+--- Page 2 ---
+Case # FINAL SURGICAL PATHOLOGYREPORT Handbook, 7th Ed, and CAP protoco Procedure: Partial nephrectomy. Specimen type: Portion of kidney. Specimen laterality: Left. TUMOR FEATURES Tumor size: 3.0x3.0x2.2cm. Tumor focality: Unifocal. Histologic type: Renal cellcarcinomapapillary variant type I. Sarcomatoid features: Not identified. Macroscopic extent of tumor: Confined to kidney. Microscopic tumor extension: Confined to kidney. LYMPH NODES: None identified. MARGIN EVALUATION: Negative. Distance to closest margin: <0.1cm. Other margins: Negative. PATHOLOGIC TUMOR STAGING DESCRIPTORS Primary tumor: pT1a. Regional lymph nodes: pNX. Distant metastasis: pMX. Margin status: RO. Pathologic stage: Case# Printed: Page2 This report continues...(FINAL) MR No. Acct No. Pathology Report - Patient Name Page 2/4 Page 2 Doc
+
+--- Page 3 ---
+Case# Pathologic findings in non-neoplastic kidney: None. Additional pathologic findings: None. Comment: N/A. Source of Specimen: A.Left renal mass B.Left renal mass margins Clinical History/Operative Dx: Renal mass Gross Description: A.The specimen is labeled left renal mass and is received without fixative.Itconsists of a nearly spherical cortical portion of renal tissue measuring 3.2 x 3.1 x 2.8 cm and weighing 16grams. There is a separate 5.5 x 3 x 0.7 cm portion of lobulated fatty tissue. The renal cortical tissue is inked at the apparent base of Case# Page3 Printed This report continues... (FINAL) MRNo Acct No Patient Name Pathology Report - Page 3/4 Page 3 Doc#
+
+--- Page 4 ---
+Patient Case# FINAL SURGICAL PATHOLOGY REPORT excision.It is serially sectioned to reveal a soft easily disrupted pale yellow to pale red neoplasm which measures 3 x 3 x2.2 cm.The non-cortical portion of the tumor appears to have a thin delicate capsule which is smooth. The neoplastic tissue centrally and paracentrally focally extends to the inked cortical margin.Representative sections of the neoplasm are obtained for research purposes.Representative sections of the neoplasm,to include the entire inked cortical margin, are submitted incassettes A1-A7 The two furthest edges of the specimen are submitted in cassette A8.Representative sections of the separate fatty tissue are submitted in cassette A9. B.The specimen is labeled left renal mass margin and is received without fixative. Itconsists of three. irregular fragments of tan to hyperemic tissue which vary from an elongatedstrip measuring 0.9 x 0.2 x 0.1 cm to a roughly rectangular 0.6 x 0.3 x 0.3 cm fragment to a 0.3 cm smallfragment. The tissue is submitted intact in cassette B1 Microscopic Description: A. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis. rendered. B.Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered. Case # Page 4 Printed: END OF REPORT (FINAL) MRNo. Acct No. Patient Name age4 Do
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diff --git a/output/text/34a8b432-1640-47f2-8c25-8e28c6f3e761.txt b/output/text/34a8b432-1640-47f2-8c25-8e28c6f3e761.txt
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index 0000000000000000000000000000000000000000..83df610cd513c9d1923474d1a9f989b0d964eb82
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+
+--- Page 1 ---
+Clinical Diagnosis & History:. Vear old female with left renal mass. Left radical nephrectomy. Specimens Submitted: 1: Soft tissue, para-aortic dissection superior margin, biopsy. 2: Kidney and para-aortic lymph nodes, left, radical neprhectomy 3: Rib, portion of ninth, segmental excision 4: Lymph nodes, interaortacaval, excision DIAGNOSIS: 1.  Soft tissue, para-aortic dissection superior margin, biopsy Benign fragment of ganglion and nerve. 2. Kidney and para-aortic lymph nodes, left, radical neprhectomy. Tumor Type:  Renal cell carcinoma - Chromophobe type Tumor Size: Greatest diameter is 17.5 cm. Local Invasion (for renal cortical types):. Extends through renal capsule but confined within Gerota's fascia Renal Vein Invasion: Not identified Surgical Margins: Free of tumor Non-Neoplastic Kidney: Unremarkable Adrenal Gland: Not involved Lymph Nodes: Free of tumor Number of nodes examined:2. Staging for renal cell carcinoma/oncocytoma:. pT3 Tumor extends into major veins or invades the adrenal gland or perinephric tissues, but not beyond Gerota's fascia  Page 1 of 3
+
+--- Page 2 ---
+3. Rib, portion of ninth, segmental excision Benign bone and bone marrow elements. 4. Lymph nodes, interaortacaval, excision Lymph Nodes: Not involved Number of nodes examined:4. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL).AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Special Studies: Result Special Stain Comment RECUT Gross Description: 1) The specimen is received fresh for frozen section consultation, labeled, "Para-aortic dissection superior margin", and consists. of a piece of cylindrical soft tissue measuring 1.1 x 0.3 x 0.3 cm.It contains multiple metal clips. Cut section shows rubbery red-tan appearance. The specimen is entirely frozen. Summary of sections: FSC-frozen section control 2) The specimen is received fresh, labeled, "Left kidney and para-aortic lymph nodes".  It consists of a kidney with.  surrounding perirenal adipose tissue and adrenal gland weighing 1900g and measuring 21.0 x 17.0 x 7.0 cm. The specimen is bivalved revealing a large yellow-red mass with focal areas of fibrosis measuring 17.5 x 17.0 x 7.0 cm.  It occupies a predominance of the kidney with only a small portion of uninvolved renal parenchyma present which measures 4.5 x 4.5 cm in maximal dimensions.  Serial sectioning of the mass reveals it to extend through the renal capsule but the mass appears still encapsulated itself.The tumor is serially sectioned revealing focal areas of yellow discoloration grossly consistent with. calcifications.The perirenal and peritumoral adipose tissue is serially sectioned revealing a V-shaped adrenal gland with. hemorrhage measuring 4.5 x 2.5 x 0.6 cm.  The adrenal gland appears grossly free of tumor. The specimen includes a portion of. adipose tissue containing multiple red-tan lymph nodes ranging from 0.5 to 2.8 cm in greatest dimension. The 2.8 cm and 1.2 cm lymph node are both bisected All identified lymph nodes are submitted for histologic evaluation.  Representative portions of the. tumor are submitted fo Representative portions of the specimen are submitted for histologic evaluation. Summary of Sections: HM -- vascular hilar margins KID  kidney without tumor AD-adrenal gland BLN -- single bisected lymph node cassettes 14 and 15 LNS-additional lymph nodes BLN - single bisected lymph node cassette 17 T-tumor 3) The specimen is received fresh, labeled, "Portion of ninth rib". It consists of a curvilinear fragment of rib measuring 15.0. cm in length x 1.0 cm in maximal diameter. The specimen is serially sectioned revealing essentially unremarkable rib. Representative sections of the specimen are submitted, pending decalcification.. Page 2 of 3
+
+--- Page 3 ---
+Summary of Sections: RIB -- ninth rib 4)  The specimen is received in formalin, labeled, "Interaortacaval lymph nodes". It consists of an irregularly shaped fragment of red-tan soft tissue and lymphoid tissue measuring 2.8 x 1.9 x 0.5 cm. The specimen is serially sectioned revealing  multiple lymph nodes ranging from 0.6 to 1.0 cm in greatest dimension.The specimen is entirely submitted. Summary of Sections: LNS - lymph nodes Summary of Sections: Part 1:  Soft tissue, para-aortic dissection superior margin, biopsy Block Sect. Site PCs 1 fsc 1 Part 2:  Kidney and para-aortic lymph nodes, left, radical neprhectomy Block Sect. Site PCs 1 AD 1 3 BLN 3 1 HM 1 1 KID 1 1 LNS 1 10 T 10 Part 3: Rib, portion of ninth, segmental excisior Block Sect. Site PCs 1 RIB 1 Part 4:Lymph nodes, interaortacaval, excision Block Sect. Site PCs 2 LNS 2 Intraoperative Consultation: Note:The diagnoses given in this section pertain only to the  tissue sample examined at the time of the intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS:  BENIGN NERVE AND GANGLION PERMANENT DIAGNOSIS: SAME Page 3of 3 END OF REPORT
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diff --git a/output/text/34aa9b45-033c-428c-b30b-5ecb771e8f02.txt b/output/text/34aa9b45-033c-428c-b30b-5ecb771e8f02.txt
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index 0000000000000000000000000000000000000000..61690fad9dfb8be8fbbc8db831a02ee7467faa15
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+jcd-o -3 brast, NOs c50.9 10/14/10 Site Cod. TSS Pt ID: 1 UUID:5DAC95DD-5DA6-475B-AC14-5C79FC2F30A6 TcGA-E2-A10b-01a-pr Redacted SPECIMENS: A. BREAST CA INFERIOR LEFT BREAST B. SENTiNEL LYMPH NODE #1 C. SENTINEL LYMPH NODE #2 D. COMPLETE AXILLARY CONTENTS-LEFT SPECIMEN(S): A. BREAST CA INFERIOR LEFT BREAST B. SENTINEL LYMPH NODE #1 C. SENTINEL LYMPH NODE #2 D. COMPLETE AXILLARY CONTENTS-LEFT INTRAOPERATIVE CONSULTATION DIAGNOSIS: FSA: Breast cancer, inferior, left breast: One mass measures 3.8 x 3.4 x 2.6 cm. The mass is 0.3 cm from medial margin and 0.3 rm from lateral margin.. By called to at TPB. Sentinel lymph node #1: Metastatic carcinoma.. By Dr, called to Dr. at GROSS DESCRIPTION: A. BREAST CA INFERIOR LEFTBREAST Received fresh labeled with patient name designated "a. breast ca inferior left breast" is a portion of. resected breast tissue weighing 50 gm and measuring 6.0 x 4.0 x 3.5 cm. The overlying beige-tan ellipse of skin measures 5.0 x 3.0 cm. The surface of the skin has a thickened rough appearance. The specimen is received with orientation, the single suture designating anterior, double-lateral and triple- superior. Specimen is inked as follows: superior-red, inferior-orange, posterior-black, medial-green, Iateral-yellow. The specimen is serially sectioned from superior to inferior. Cut section shows a firm il! defined beige-tan mass measuring 3.8 x 3.4 x 2.6 cm approaching the closest medial margin at. distance of 0.3 cm and lateral margin at distance of 0.3 cm. The skin appears grossly involved by the lesion. The remainder of the specimen shows dark yellow lobulated adipose tissue with focal areas of firm white fibrous parenchyma. A portion of the specimen is submitted for tissue procurement. Representative sections are submitted as follows:. A1-A2: slice 1, bisected serial section of the mass and skin with lateral and medial margins A3-A4: sections of inferior margin with skin, slice 1 A5-A6: slice 2 additional lesion and skin with medial and lateral margins A7-A8: slice 2 additional sections of lesion with lateral and posterior margins. A9-A14: slice 3 totally submitted A15-A18: slice 4 entirely submitted A19-A20: perpendicular sections superior margin B. SENTINEL LYMPH NODE #1 Received fresh labeled with the patient name designated "b. sentinel lymph node #1" are 2 firm lymph nodes measuring 0.9 x 0.6 x 0.5 cm and 0.8 x 0.5 x 0.5 cm. Both lymph nodes are bisected to show white cut surface. Touch preps are performed. Both lymph nodes are entirely submitted in cassettes B1-B2 C. SENTINEL LYMPH NODE #2 Received fresh labeled with the patient name designated "c. sentinel lymph node #2" is a fragment of firm yellow-tan fibroadipose tissue measuring 5.0 x 1.5 x 0.5 cm. The entire specimen is submitted in cassettes C1-C2. D. COMPLETE AXILLARY CONTENTS-LEFT Received in formalin in a container labeled with patient name designated "d. complete axillary contents- left" is a portion of yellow-tan fibroadipose tissue measuring 9.4 x 6.2 x 3.1 cm. Multiple possible lymph nodes are identified ranging in size from 2.2 x 0.5 x 0.5 to 0.2 x 0.1 x 0.1 cm. Cassettes are submitted as follows: D1: 2 possible lymph nodes D2: 3 possible lymph nodes D3: 3 possible lymph nodes D4: 3 possible lymph nodes D5-D15: multiple additional possible lymph nodes DIAGNOSIS: A. BREAST, LEET INFERIOR, EXCISIONAL BIOPSY: - INVASIVE, DUCTAL CARCINOMA, SBR GRADE 3, MEASURING 2.6-CM,
+
+--- Page 2 ---
+INVOLVING FIBROADENOMA AND EXTENDING INTO SUPERFICIAL DERMIS - INTERMEDIATE, NUCLEAR GRADE, DUCTAL CARCINOMA IN SITU, WITH CENTRAL NECROSIS, CRIBRIFORM AND SOLID TYPES - TUMOR PRESENT WITHIN 1 MM FROM MEDIAL, LATERAL, AND SUPERIOR SURGICAL RESECTION MARGINS - PERINEURAL INVASION AND FOCAL LYMPHOVASCULAR INVASION IDENTIFIED - FIBROCYSTIC CHANGES WITH FIBROSIS AND SCLEROSING ADENOSIS - SEE SYNOPTIC REPORT. B. LYMPH NODE, SENTINEL #1, LEFT, BIOPSY: - METASTATIC CARCINOMA TO TWO OF TWO LYMPH NODES (2/2) LARGEST MEASURING 0.8 CM, WITH FOCAL EXTRANODAL EXTENSION. C. LYMPH NODE, SENTINEL #2, LEFT, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1). D. LYMPH NODES, LEFT AXILLARY CONTENTS, EXCISIONAL BIOPSY: - TWENTY FIVE LYMPH NODES, NEGATIVE FOR METASTASES (0/25). SYNOPTIC REPORT - BREAST Specimen Type: Excision Needle Localization:  No Laterality:Left; Invasive tumor: Present Multifocality: No WHO CLASSIFICATION Invasive ductal carcinoma, NOs 8500/3 Tumor size: 2.6cm Tumor site: Not specified Margins: Negative Distance from closest margin: 0.1cm medial lateral and superior Tubular score: 3 Nuclear grade: 2 Mitotic score:3 Modified Scarff Bloom Richardson Grade: 3 Necrosis: Absent Vascular/Lymphatic Invasion: Present Extent: focal Lobular neoplasia: None Lymph nodes: Sentinel lymph node and axillary dissection Lymph node status: Positive 2 / 28 DCIS present Margins uninvolved by DCIS: DCIS Quantity: Estimate 5% DCIS type: Solid Cribriform DCIS location: Associated with invasive tumor Nuclear grade: Intermediate Necrosis: Present ER/PR/HER2 Results ER: Pending PR: Pending HER2: Pending Pathological staging (pTN): pT 2 N 1a CLINICAL HISTORY: Left breast cancer invading skin
+
+--- Page 3 ---
+PRE-OPERATIVE DIAGNOSIS: Left breast ca ADDENDUM: SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimen: Surgical Excision Block Number: A1 ER: Positive Allred Score: 8 = Proportion score: 5 + Intensity Score 3 PR: Positive Allred Score: 8 = Proportion Score 5 + Intensity Score 3 COMMENT: The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cels staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring. range from 0 to 8. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2.. Methodoloqy: Fixation Type and Length: Tissue was fixed in 10% neutral buffered formalin ( ) for no less than 8 and no longer than 24 hours. Antibody and Assay Methodology:  Mouse anti-human ER and PR, Comment: This assay can be used to select invasive oreast cancer patients for hormone therapy (1). ER and PR analysis was performed on this case by immunohistochemistry utilizing the ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) antibody provided by , following the manufacturer's instructions listed in the package insert. This assay was not moditied, and adherence to all instruction and guidelines were strictly followed. Interpretation of the ER/PR immunohistochemical staining. characteristics is guided by published results in the medical literature (1), information provided by the reagent manufacturer and by internal review of staining performance within the Pathology Department.. 1. Harvey JM, et al. Estrogen receptor status by immunohistochemistry is superior to the ligand-binding assay for predicting response to adjuvant endocrine therapy in breast cancer. J Clin Oncol. 17:1474- 1481, 1999 SYNOPTIC REPORT - BREAST HER-2 RESULTS HER2 Status Results, Immunohistochemistry Evaluation Specimen: Surgical Excision. Block Number: A1 Interpretation: EQUIVOCAL Intensity: 2+ % Tumor Staining: 10% Fish Ordered: Yes , on Date METHODOLOGY Methodoloav: Fixation Type and Length: Tissue was fixed in 10% neutral buffered formalin ( ) for no less than 8 and no longer than 24 hours. Antibody and Assay Methodology: Rabbit anti-human HER2, HerceptestTM (FDA-approved test kit), Control Slides Examined: External kit-slides provided by manufacturer (cell lines with high, low and negative HER2 protein expression), and in-house known HER2 amplified control tissue were evaluated along with the test tissue. These control slides run along side of this patient's sample showed appropriate staining. Adequacy of Specimen: Adequate, well preserved, clear-cut invasive carcinoma identified for. HER2 evaluation.. Scoring Criterion and Scoring System:. IHC Level of Expression(Score) /Tumor Cell Membrane Staining Pattern Negative (0)/Absence of Staining. Negative (1+)/Faint Incomplete membrane Staining, >10% of Cells Equivocal (2+)/Weak complete membrane Staining, >10% of Cells Positive (3+)/Strong complete membrane Staining, >10% of Cells Equivocal Category for HER2 IHC results: A HER2, 2+ staining result that is interpreted as equivocal may not indicate gene amplification. A FISH test for HER2 gene amplification will be ordered for all HER2 IHC 2+ results. COMMENT This assay can be used to select invasive breast cancer patients for Trastuzumab (Hereptin) therapy (1,2). Clinical Trials have shown that Trastuzumab substantially increases the likelihood for an objective
+
+--- Page 4 ---
+response and overall survival for patients with metastatic HER2-positive breast cancer, regardless of whether HER2 tumor status was determined as IHC 3+ or FISH positive. Trastuzumab added to adjuvant chemotherapy substantially increase disease-free survival and decreases the risk of disease recurrence by about 50% for patients with early-stage HER2 protein over-expressed or gene amplified invasive breast cancer (3). HER2 analysis was performed on this case by immunohistochemistry utilizing the FDA approved HercepTest (TM) test kit following the manufacturer's instructions listed in the package insert. This assay was not modified, and adherence to all instruction and guidelines were strictly followed. Interpretation of the HER2 immunohistochemical staining characteristics is guided by published results in the medical literature (4), information provided by the reagent manufacturer and by internal review of staining performance within the Pathology Department.. HER2 TEST VALIDATION This HER2 immunohistochemical assay has been validated according to the recently revised recommendations and guidelines from the NCCN HER2 testing in Breast Cancer Task Force, and the jointly issued recommendations and guidelines from ASCO and the CAP (5). 80 randomly selected breast cancer samples were tested for HER2 by IHC as outline above and interpreted as, negative (score 0/1+) equivocal (score 2+) and positive (score 3+) without knowledge of the previous reported results. These cases were also blindly read using two different FISH assay as amplified or non-amplified and the HER2/CEP17 ratios were recorded. After analyzing these results, there was 100% concordance between the IHC and FISH results for cases that were interpreted as either positive or negative by IHC. 9 of the 80 cases were interpreted as equivocal by IHC and of these 3/9 (33%) were non-amplified by FISH and 6/9 (66%) were found to be amplified.. The Pathology Department Immunohistochemistry laboratory takes full responsibility for this tests performance and has programs in place to regularly monitor the proficiency and the interpretation of HER2 assays. The laboratory also participates in external quality assurance HER2 programs including the CAP proficiency testing program. REFERENCE 1. Carlson RW, Anderson BO, Burstein HJ, et al., NCCN breast cancer clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2005;3:238-289. 2. Carlson RW, Brown E, Burstein HJ, et al., NCCN Task Force Report: adjuvant therapy for breast cancer. J Natl Compr Canc Netw. 2006;4:S1-S26. 3. Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Eng J Med 2005;353(16):1673-84 4. Leong ASy, Formby M, Haffajee Z, et al. Refinement of immunohistologic parameters for Her2/neu scoring validation by FISH and ClSH. App! Immunohistochem Mol Morphol. 2006;14:384-389. 5. Wolff AC, Hammond EH, Schwartz JN, et al., American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Human Epidermal Growth Factor Recepto 2 Testing in Breast Cancer. Arch of Path and Lab Med 2007; 131:18-43. PathVysion HER-2 DNA Probe Kit Case No Analytical Interpretation of Results: HER-2 NOT AMPLIFIED Clinical Interpretation of results Amplification of the HER-2 gene was evaluated with interphase fluorescence in-situ hybridization (FiSH) on formalin-fixed paraffin embedded tissue sections using a chromosome 17 centromeric probe and a HER-2 probe that spans the entire HER-2 gene in the . A majority of tumors cells displayed 2 chromosome 17. signals and 2 HER-2 signals, with a HER-2/CEP 17 Ratio </=2.0, consistent with no amplification of the HER2/neu gene. Block used A1. Source of case: RPCI Tissue fixation. formalin-fixed tissue Outside Case No:NA Tissue sourcee breastResults interpreted: yes HER2/CEP17 ratio: 1.11 This ratio is derived by dividing the total number of LSI HER-2/neu signals by the total number of CEP17 signals in at least 20 interphase nuclei with nonoverlapping nuclei in the neoplastic mammary epithelial cells. Cells with no signals or with signals of only one color are disregarded. Method of ratio enumeration:  manual count Limitations The Vysis PathVysion Kit is not intended for use to screen for or diagnose breast cancer. It is intended to be used as an adjunct to other prognostic factors currently used to predict disease-free and overall survival in stage Il, node-positive breast cancer patients. In making decisions regarding adjuvant CAF treatment, all other available clinical information should also be taken into consideration, such as tumor size, number of involved lymph nodes, and steroid receptor status. No
+
+--- Page 5 ---
+treatment decision for stage Il, node-positive breast cancer patients shouid be based on HER. 2/neu gene amplification status alone Overview of this test. FDA APPROVED REAGENT PathVysion HER-2 DNA Probe Kit is FDA approved for selection of patients for whom Herceptin therapy is being considered. These tests were performed in the . under the direction of Dr.. The results of these studies should always be interpreted in the context of the. clinical, morphological, and immunophenotypic diagnosis.. Gross Dictation: Pathologist,  Microscopic/Diagnostic Dictation:., Pathologist,. Final Review: Patholoaist : Final: Pathologis. Addendum: Pathoiogist, Addendum Final.., Pathologist. Addendum: Pathologist,. Addendum Final:., Pathologist,
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diff --git a/output/text/34bf2fa0-9dc7-4664-9dca-48584d71614a.txt b/output/text/34bf2fa0-9dc7-4664-9dca-48584d71614a.txt
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index 0000000000000000000000000000000000000000..52d4104ab1457e67ec3c3b13564dc1481ef80648
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+Diagnosis/ diagnoses: Resected section of (sigmoid) colon with a colon carcinoma characterized histologically as a moderately differentiated colorectal adenocarcinoma, extending to within 8 cm of a resection margin and encircling the intestinal wall over a length of 7 cm. Invasive tumor spread to the muscularis propria. Oral and aboral resection margins are tumor-free.. Twenty-two mesocolic lymph nodes are tumor-free and have uncharacteristically reactive. lesions. Stage of tumor is therefore: pT2 pN0 (0/22) L0 V0; G2 Follow-up report: As requested an examination was initiated in relation to the question over microsatellite instability of the colon tumor.. According to the current consultation report (see appendix) there is no further evidence of. the presence of significant tumor disposition, particularly of the HNPCC/ Lynch syndrome type.
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diff --git a/output/text/34dac150-f76c-4b3c-860d-7e51cc6c4b66.txt b/output/text/34dac150-f76c-4b3c-860d-7e51cc6c4b66.txt
new file mode 100644
index 0000000000000000000000000000000000000000..60a67f37f3b3a9fa6fbef73df9b0c2dae06c9bbc
--- /dev/null
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+1cs-0-3 Casn^mn,vnfiItratxy duct,Nos 85oof3 UUID: 1159E2EF-6407-4D90-8ED6-7AB04CF4FB32 TCGA-A7-A26H-01A-PR Redacted Site? srast Nus C50.9 4/27/11 DEPARTMENT OF PATHOLOGY AND LABORATORY MEDICINE Date Coll: SURGICAL PATHOLOGY REPORT SPECIMEN A. Left axillary sentinel node B. Left breast (arrow points up) C. Right axillary sentinel node D. Right axillary sentinel node #2 active in blue E. Right breast (arrow points up). F. Left axillary contents CLINICAL NOTES PRE-OP DIAGNOSIS:  Bilateral breast. FROZEN SECTION DIAGNOSIS A) Sentinel lymph node, left axilla, biopsy: One lymph node, positive for carcinoma. C. Sentinel lymph node, Jpoy: One lymph node, negative for carcinoma. D. Sentinel lymph node, right axiiia #2, biopsy: One lymph node, negative for carcinoma. GROSS DESCRIPTION A. The specimen is received unfixed labeled "left axillary sentinel. noand consists of a yellow and red piece of soft tissue measuring 2.5 x 2 x 0.8 cm.  On cut section there is a contained lymph node measuring 1.2 cm. in greatest dimension. The node is bis submitted all for frozen section diagnosis as requested.. B. The specimen is received unfixed labeled "left breast arrow points up" and consists of a breast resection specimen measuring 19.5 x 18.5 x 3.0 cm. There is an overlying white ellipse of skin measuring 16 x 9.3 cm.  There is a central areola measuring 3 x 4 cm. and a central nipple measuring 1.2 x 1 x 0.4 cm.  There is an arrow incised in the skin and there is an area of induration at the superior edge of the areola that might be a biopsy scar. It measures 1.5 x 0.7 cm. The deep surface of the specimen is inked. The breast is sectioned at 1 cm. intervals in the deep surface towards the skin. Some blue-domed cysts are present.  There is a relatively central red area compatible with a firm area measures 1.5 x 1.5 x approximately 1.5 cm. central and inferior and there is another area that is central below the indurated part of the skin that looks like carcinoma grossly and. measures 1.2 x 1.5 x approximately 1.5 cm. A portion of the larger area is taken for research purposes. Sections after fixation. Block summary: 1,2 nipple and skin with tumor; 3 deep margin; 4-6 C. Received unfixed labeled "right axillary sentinel node" and consist of two pieces of yellow and red soft tissue measuring 2 x 1.8 x 0.7 cm. and 2.5 x 2.5 x 0.7 cm. There is a contained lymph node measuring 1 cm.  in greatest dimension and the entire node is submitted for frozen section diagnosis as requested.
+
+--- Page 2 ---
+ Received unfixed labeled "right axillary sentinel node. D. #2 active in blue" and consist of a yellow, red and blue piece of soft tissue measuring 5.5 x 3 x 0.6 cm..  There is a partially blue contained lymph node measuring 2.3 cm. in greatest dimension. The specimen is submitted all for frozen section diagnosis as requested.. E. (The original gross dictation on specimen E. is lost.) The specimen was received unfixed labeled right breast and consisted of a 27 x 19 x 4.5 cm breast resection specimen with overlying ellipse of skin measuring 16.5 x 9 cm. There was a central areola and nipple. An area of arrow was incised to the skin. Some blue dye and injected. The deep surface the specimen was inked and the breast resection at 1 cm intervals from the deep surface towards the skin. There was a central biopsy site and additional relatively central firm area compatible with carcinoma. Block summary: 1,2 nipple; 3 skin; 4 - deep margin; 5-7 biopsy site; 8,9 area resembling tumor; 10-13 quadrants (U0.uI.L0.LI) F. The specimen was received unfixed, labeled "left. axillary contents" and consists of a yellow and pink of. soft tissue measuring 12 x 8 x 2 cm. RS-2. MICROSCOPIC DESCRIPTION A. Metastatic carcinoma is present in one lymph node. The tumor is 0.7 cm in diameter. No extranodal tumor is seen. B. Invasive carcinoma Tumor type: Infiltrating ductal carcinoma Tumor grade: 1 (Elston SBR grade; A/N/M = 2/2/1) Mitotic index: 3 mitoses/10 HpFs (1 HPF = 0.196 sq mm) Tumor size: 1.5 cm Vessel invasion:  Absent Calcification:  Absent pTNM stage: T1 pNla Prognostic markers:  Requested Nipple: Carcinoma is present in skin adjacent to the nipple Deep margin: Negative for malignancy  Sections from the biopsy site away from Nontumorous breast: benign calcification, usual ductal hyperplasia and focal atypical ductal hyperplasia. C. A Single lymph node is negative for malignancy D. A single lymph node is negative for malignancy E. Invasive carcinoma Tumor type: Infiltrating ductal carcinoma. Tumor grade: 2 (Elston SBR grade; A/N/M = 3/2/1) Mitotic index: 3 mitoses/10 HPFs (1 HPF = 0.196 sq mm) Tumor size: 1.2 cm on the glass slide. Vessel invasion: Absent Calcification: Absent T1 pTNM stage: Prognostic markers: See previous biopsy The tumor is specimen E from the right breast has a central fibrotic focus.
+
+--- Page 3 ---
+Sections near the biopsy site away from the gross carcinoma described above show columnar metaplasia, usual ductal hyperplasia, cyst formation apocrine metaplasia. An atypical area is p63 positive. F. There is no evidence of malignancy in any of 4 lymph nodes. 4x6,25x3,20,14x3 DIAGNOSIS A. Sentinel lymph node, left axilla, biopsy: Metastatic carcinoma in a single lymph node Primary B. Breast, Ieft, resection: Infiltrating ductal carcinoma, Elston SBR grade 1 c. Sentinel lymph node, right axilla, biopsy: A single lymph node is negative for malignancy D. Sentinel lymph node #2, right axilla, biopsy: A single lymph node is negative for malignancy Bi|ktwud E. Breast, right, resection: Infiltrating ductal carcinoma, Elston SBR grade 2 F. Lymph nodes, left axilia, biopsy! There is no 3uwt e+ evidence of malignancy in any of 4 lymph nodes :ctronic Signature) End Of Report
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diff --git a/output/text/34e345b1-9b97-45f2-bd39-99abf23e2c0c.txt b/output/text/34e345b1-9b97-45f2-bd39-99abf23e2c0c.txt
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index 0000000000000000000000000000000000000000..9f3166380aa4609f39962fb6620bbcbca1baa00a
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+1cs-0-3 Cascinmr,nifil+nuHg 1obnlw,N0s 8570/3 Sih: busot, Nos. c5v.9 DIAGNOSIS 10/3/12 (A) LEFT AXILLARY SENTINEL LYMPH NODE #1, BIOPSY: METASTATIC CARCINOMA IN ONE LYMPH NODE. LYMPH NODE METASTASIS MEASURES 7.0 MM IN GREATEST MICROSCOPIC DIMENSION. EXTRANODAL EXTENSION IS PRESENT AND MEASURES 2.0 MM IN GREATEST DIMENSION. CYTOKERATIN IMMUNOSTAINING ON REPRESENTATIVE SECTION CONFIRMS THE PRESENCE OF METASTATIC CARCINOMA. (B) Left breaSt, mAstecTomy:  INVASIVE LOBULAR CARCINOMA, MODIFIED BLACK'S NUCLEAR GRADE 1-2 (LOW TO INTERMEDIATE GRADE) WITH FOCAL SIGNET RING CELL FEATURES. 9% stgut ^5 pw rss INVASIVE CARCINOMA INVOLVES AN AREA OF APPROXIMATELY 8.5 CM IN THE LATERAL ASPECT. Definitive lymphovascular invasion is not identified. A SMALL FOCUS OF INVASIVE CARCINOMA IS PRESENT 8.0 MM FROM THE INFERIOR MARGIN. Other resection margins widely free of tumor. Stromal fibrosis, columnar cell change and cysts. Nipple skin with basaloid follicular hamartoma; no carcinoma identified. (C) LEFT AXILLARY CONTENTS, DISSECTION: METASTATIC CARCINOMA IN NINE OF TWENTY-ONE LYMPH NODES. LARGEST LYMPH NODE METASTASIS MEASURES 5.0 MM IN GREATEST MICROSCOPIC DIMENSION. Focal extranodal extension is present. UUID:D80291E6-E371-40F8-BDB3-0F85F01583DE re report and diagnosis completed by TCGA-GM-A4E0-01A-PR Redacted GROSS DESCRIPTION (A) LEFT AXILLARY SLN #1, BLUE IN VIVO 13, EX VIVO 31 - One blue lymph node 3.0 x 2.0 x 0.7 cm. Serially sectioned and entirely submitted in A1-A3 for frozen evaluation (A1, suture to hot spot). *FS/DX: METASTATIC CARCINOMA. (B) LEFT BREAST - A total mastectomy specimen 26.0 x 21.0 x 8.5 cm with white-tan skin (26.0 x 17.5 cm and nipple 1.2 cm in diameter). The specimen is oriented with stitch at 12 o'clock. The superior margin inked blue, inferior margin inked orange, deep margin inked black. The specimen is serially sliced from medial to lateral in twelve slices and nipple at slice #4. An irregular tumor. 8.5 x 4.5 x 2.0 cm is identified in the lateral portion (slice #7-slice #9). The tumor is 2.0 cm to the inferior margin, 5.0 cm to the superior margin and 6.0 cm to the deep margin. SECTiON CODE: B1, B2, nipple B3, tissue adjacent to the tumor from slice #6; B4-B6, tumor from slice #7 from superior. to inferior; B7-B12, tumor and margins from slice #8 (B7-B10, tumor from superior to inferior); B11, inferior margin; B12 (deep margin); B13-B17, tumor and inferior margin from slice #9; from superior to inferior (B17 including inferior margin); B18, tissue adjacent to the tumor from slice #10; B19, representative section from upper inner quadrant including superior margin; B20, representative section from lower inner quadrant including inferior margin; B21, fibrous tissue from upper outer quadrant with superior margin from slice #5; B22, fibrous tissue from upper outer quadrant with superior margin from slice #6; B23, representative section from lower outer quadrant including inferior margin. (C) LEFT AXILLARY CONTENTS - Adipose tissue (11.0 x 5.5 x 2.5 cm). Twenty-two lymph nodes are identified, ranging from (0.2 x 0.2 x 0.2 cm to 4.5 x 1.5 x 1.0 cm). SECTION CODE: C1-C3, each cassette containing six lymph nodes; C4, three lymph nodes; C5-C9, one lymph node serially sectioned.. NICAL HISTORY Left breast cancer.. CONSULTANT(S)
+
+--- Page 2 ---
+SNOMED CODES T-04050, M-85203, T-C4710, M-85206 These tests have not been "Some tests reported here may have been developed and performance characteristics determined by specifically cleared or approved by the U.S. Food and Drug Administration." Released by: ---END OF REPORT--
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diff --git a/output/text/34e6b4c7-a022-4d40-a9a8-d65176a32404.txt b/output/text/34e6b4c7-a022-4d40-a9a8-d65176a32404.txt
new file mode 100644
index 0000000000000000000000000000000000000000..df2867683dd14a5d37c9823f310b3919fd6df191
--- /dev/null
+++ b/output/text/34e6b4c7-a022-4d40-a9a8-d65176a32404.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+/cs-0-3 Cunnioma,Fnfiltatig Suct, NvS Sits. Prot,nos C5u.9. Procedure Date:a UUID:DA6A0EC9-6E20-4E4A-9B7F-A32EFF7627AD TCGA-BH-A1FM-01A-PR Redacted Patient hIstory: * DATE OF LP: * DATR OF LAST DELIVERY: : PRR-OP DIACNOSIS: RT BREAST CA POsT-OP DIAGNOSIS: SAME OPERATIVE PROCEDURE: RT MAST, A D : CLINICAL HISTORY: MATERIAL SUENITTED: RIGHT (MOD) RADICAL MASTECTOMY, PROCUREMENT BY SURGICAL PROCEDURES FINAL DIAGNOSIS: PrEVIoUS REpoRTS: BY O.5BY0.5CM) EXTBNSIVE DUCTAL CARCINOMA IN SITU, COMEDO AND NON-COMEDO TYPES, COMPRISINC >25t OF TUMORS ANGIOLYMPRATIC INVASION PRESENT TUMOR ASSOCIATED MICROCALCIFICATIONS MARGIN OF RESECTION NEGATIVE FOR TUMOR _TUMOR APPROACHES POSTERIOR MARGIN WITH 1.O MM SKIN OF NIPPLE AND AREOLA INVOLVED BY TUMOR FIBROCYSTIC CHANGES SIGHT OUT OF TEN (8/IO) LYMPH NODES POSTTIVE FOR TUMOR WITH EXTRACAPSULAR EXTENSION IN FIVE (5) POSITIVK NODES NoTe: eR/pR immunoperoxidase assay will be performed on paraffin ambedded tissue, block 3. An addendum report will follow. SUPDLEMENTALRERORT (ER/PR'S) IMMUNOPEROXIDASE IDENTIFICATION OF ESTROGEN AND PROGESTERONE RECEPTORS IS CARRIED OUT ON SLIDE A3. DISTINCT INTRANUCLEAR STAINING IS IDENTIFIED. FOR ESTROGEN RECEPTOR (SOt). BUT NOT FOR PROGESTERONE RECEPTOR. THEREFORE, ESTROGEN RECEPTOR IS INTERPRETED AS POSITIVE AND PROGESTERONE RECEPTOR AS NEGATIVE.
\ No newline at end of file
diff --git a/output/text/35016fff-ed18-45a1-a5a1-20e0f5f33c8f.txt b/output/text/35016fff-ed18-45a1-a5a1-20e0f5f33c8f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0bc03e951fc6e05c8e5ac5582e205975088dadef
--- /dev/null
+++ b/output/text/35016fff-ed18-45a1-a5a1-20e0f5f33c8f.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+Department of Pathology Page 1 of 4 UUID:A71F24D0-ADE3-4608-9941-47B025FD6A16 REPORT Tel: TCGA-VD-A8KG-01A-PR Redacted Clinical Consultant & Location  Sex Unit No This Copy For: Ic d-6-3 B 8734/3 SPECIMEN MLilsnono  poidle eelQ Iype cE9.3 Right globe Site  Chorsid  CLINICAL DETAILS 17]14 Right eye floaters and visual field defect and flashes of light since Seen at local eye unit and ultrasound was suggestive. of collar-stud choroidal melanoma - referred to. diagnosis confirmed. Tumour and exudative detachment.. Largest diameter 11.34mm. Thickness 7.6mm. Post ora. MACROSCOPIC DESCRIPTION An intact right eye. Dimensions: Axial 24.5mm, Horizontal 23mm, Vertical 23mm Cornea: Horizontal 12mm, Vertical 1lmm. Optic nerve Length 4mm, Diameter 4mm Pupil: regular, normal depth. On trans-illumination, a dark shadow seen inferior posteriorly measuring approximately 13 x 10mm, and 5mm from. optic disc. Plane of section: vertical. Intraocular description: On opening, a dome shaped tumour is seen, pale and fragmented. Height 7mm LBD 12mm MICROSCOPY Sections show a focally pigmented choroidal melanoma with attached adjacent normal  choroid and sclera and associated with exudative / haemorrhagic retinal detachment. The tumour. consists predominantly of spindle cells. The number of Reported:. Pathologist: Electronically Verifled:
+
+--- Page 2 ---
+crinled: Department of Pathology Page 2 of 4 HISTOPATHOLOGY REPORT Tel: Surname Lab No Clinical Consuitant & Location Forename(s)  DOB/Age Sex Unit No Request Date This Copy For: mitosis is approximately 1/40 high power fields. The loops are not present in the planes of section. The lymphocytic infiltrate within the tumour is minimal. Tumour necrosis is not seen. There is focal tumour extension into the sclera through a vascular channel. No evidence of tumour veins examined. Tumour cells are not seen at the resection margins. Elsewhere, the cornea shows no significant abnormality. The anterior chamber angles are open and the anterior chamber is deep. The iris shows no significant abnormality but the ciliary body appears atrophic with hyalinisation of ciliary processes. The lens shows subcapsular degenerative changes. Retina overlying the tumour is slightly atrophic and Bruch's membrane appears breached in the sections examined. DIAGNOSIS Right eye, enucleation: Choroidal melanoma of predominant spindle cell type. COMENT Immunohistochemistry for assessment of expression of Melan-A and Hsp27 by tumour cells will be performed. Molecular genetic examination of DNA extracted from the tumour celis will be also carried out using multiplex-ligation dependent probe amplification (MLpA). looking at chromosomes 1, 3, 6 and 8.~A supplementary report will follow in due course. SUPPLEMENTARY REPORT In the meantime, molecular genetic analysis of tumour DNA extracted from the fresh uveal melanoma tissue was performed using the technigue termed multiplex ligation-dependent probe amplification (MLpA). These investigations were performed in the Reported: Pathologist: Electronlcally Verified:
+
+--- Page 3 ---
+Department of Pathology. Page 3 of 4 HISTOPATHOLOGY REPORT Tel: Surname Lab No Clinical Consuitant & Location Forename(s) DOB/Age Sex UnIt No  Request Date This Copy For:e The kit p027B from which examines for gains or. losses in 31 loci on chromosomes 1, 3, 6 and 8, was used. The DNA concentration was measured using : and the quality assessed using multiplex-pcr prior to the MLPA reaction. The DNA concentration was high and of good quality on assessment. The MLpA reaction was run at least twice on. differing occasions, resulting in similar results.. The results of the sequence analysis of the MLpA products is printed on a separate report. In summary, sequence analysis demonstrated: 4 borderline losses on chromosome 1, 7 borderline losses in chromosome 3 (equating to chromosome 3 loss), gains of chromosome 6p, and gains of chromosome 8q.. These molecular data require correlation with the clinical and morphological data for metastatic risk assessment. SUPPLEMENTARY AND FINAL REPORTS In the meantime immunohistochemistry was performed: the. tumour cells demonstrate positivity for MelanA, BAP1. (cytoplasmic only). and Hsp-27 (score 3). COMMENT SPECIMEN 2= Eye TUMOUR PRESENT Yes TUMOUR TYPE 1- Melanoma CELL TYPE 2- Spindle B CT LOOPS 1= No closed loops NECROSIS  No PIGMENTATION Yes LYMPHOCYTIC INFILTRATIONS No MITOTIC FREQUENCY 1 /40 HPF Reported: Pathologist: Electronically Verified:
+
+--- Page 4 ---
+Department of Pathology Page 4 of 4 HISTOPATHOLOGY REPORT Tel:  Surname Lab No Clinical Consultant & Lacation Forename(s) DOB/Age Sex Unit No Request Date This Copy For: DIFFUSE MELANOMA No SPREAD 2= Intra-scleral CLEARANCE 2- Adequate HSP-27 POSITIVITY 3= >70* LARGE DIAMETER 11.3 mm THICKNESS 7.6 mm Reported: Pathologist: Electronically Verified:
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diff --git a/output/text/351daa54-990c-4e58-972c-1f7c9dac5ada.txt b/output/text/351daa54-990c-4e58-972c-1f7c9dac5ada.txt
new file mode 100644
index 0000000000000000000000000000000000000000..17c7c4825d5bd51b982ac632a5e1112c3df0ab24
--- /dev/null
+++ b/output/text/351daa54-990c-4e58-972c-1f7c9dac5ada.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TCD-O-n @reinome, wrstteliol UUID:E0AF3F47-9EBB-4E83-B664-6C139C75D402 8180L3 TCGA-4Z-AA7Y-01A-PR yeafeeseory Redacted C6 Site: Mlxdoer, Laterol wall Cl7.Z Kets.. Collect date: (MM/DD/YYYY) QJ3/i 8|4 PATHOLOGY REPORT: PRIMARY SITE: Bladder I-"Bladder + prostate": Papillary urothelial carcinoma of high grade, characterized as follows: . Measure of the longest axis: 3.5 cm . Infiltration up to detrusor muscle of the bladder. . Neural infiltration not observed. . Lymphatic vascular invasion not detected. . Sanguineous vascular invasion not detected. . Surgical margins free of neoplastic involvement. Nodular benign prostatic hyperplasia. Nonspecific chronic prostatitis. Lymph nodes free of neoplastic compromise (0/9). II-"Left pelvic lymphadenectomy":. Free of neoplastic involvement (0/2). III-"Right pelvic lymphadenectomy": Free of neoplastic involvement (0/7). h 1=/3s/i3
\ No newline at end of file
diff --git a/output/text/3531fdfc-d4ff-44c0-94d3-ca45f6ce9651.txt b/output/text/3531fdfc-d4ff-44c0-94d3-ca45f6ce9651.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c8e3cdbd09342d9f746ef8cba7c7c7255af5dc9d
--- /dev/null
+++ b/output/text/3531fdfc-d4ff-44c0-94d3-ca45f6ce9651.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+SPECIMEN: UUID:7A2719FC-1CA2-4D58-9EF7-59492601FF66 SURGICAL PATHOLOGY REPORT Redacted DOB. Sex: F Location: Date Collected: Date Received: tcD-0-3 Physician: CEcF Sobular Copy To lreuromc Clinical History/Diagnosis: Right Breast CA. nfillrater NoS 852d|3 Source of Specimen(s): Ssleulor 85.24/ 3 1: Sentinel nodes right axilla. aensyr 2: Right breast lumpectomy Mysol w)strer typs. NbS CsO.9 3: Final posterior margin (pectoral margin). 4: Final anterior and medial margin HO 5Q4f13 Gross Description: Received in four parts. Source of Tissue: 1. Labeled #1, "sentinel node right axilla'" Touch Preparation/Frozen Section Evaluation: TOUCH PREP NO TUMOR SEEN, FROZEN SECTION NO TUMOR SEEN PER Gross Description: Received fresh for touch preparation/frozen section evaluation labeled "sentinel node right axilla" are two tan focally blue dye stained firm 1ymph nodes, 2.0 cm in greatest dimension. They are sectioned, touch preparations are made and frozen sections are performed on each lymph node. The frozen section residues are submitted in two blocks. The remaining lymph node tissue is entirely submitted in four blocks.. Designation of Sections: 1FSA- frozen section lymph node A, 1FSB- frozen section lymph node B, 1A-1B- 1TPA, 1C-1D- 1TPB Summary of Sections: multiple. Source of Tissue: 2. Labeled #2, "right breast lumpectomy" Gross Description: Received fresh labeled "right breast lumpectomy" is a 9.0 x 7.5 x 4.5 cm yellow-tan fragment of breast tissue. It is covered in part by a 5.0 x 2.5 cm light-tan skin ellipse. There is a short stitch denoting the superior margin and a long stitch denoting the lateral margin. The margins are inked in black, the specimen is serially sectioned to reveal predominantly yellow-tan adipose tissue. There is an ill-defined, 3.0 x 2.5 x 1.6 cm firm mass having tan gritty cut surfaces with infiltrating borders. This grossly appears to jw 3|as|i>
+
+--- Page 2 ---
+come closest to the inked anterior, posterior and medial margins. Representative sections are submitted in ten blocks. Designation of Sections: 2A- superior, 2B- inferior, 2C-2D- medial, 2E- lateral, 2F-2H- anterior, 2I-2J- posterior Summary of Sections: multiple. ******************** Source of Tissue: 3. Labeled #3, "final posterior margin (pectoral margin)" Gross Description: Received fresh labeled "final posterior margin (pectoral margin)" is a 2.2 x 1.0 x 0.4 cm red-purple fragment of soft tissue and muscle. There is a stitch present marking the final margin and this area is inked in black. The specimen is sectioned and entirely submitted in one block Designation of Sections: Block 3 Summary of Sections: undesignated-multiple. Source of Tissue: 4. Labeled #4, "final anterior and medial margin" Gross Description: Received fresh labeled "final anterior and medial margin" is a 6.0 x 0.6 cm tan elliptical fragment of skin excised to a depth of 0.4 cm. The margins are inked in black, it is serially sectioned and entirely submitted in two blocks. Designation of Sections: 4A-4B Summary of Sections: multiple Final Diagnosis: 1. Right axilla, sentinel lymph nodes, excision: - Two lymph nodes with no tumor seen (0/2), see note. Note: Immunohistochemical stains for Cytokeratin will be reported as an addendum. 2. Right breast, lumpectomy:- Invasive lobular carcinoma, grade II with. microscopic focus of pleomorphic changes (3.0 cm); lymphovascular invasion is not seen. - Invasive carcinoma extends to the inked and cauterized lateral and inked anterior breast parenchymal margin; approximately 2.0 mm from the inked. posterior margin. - Focal atypical ductal hyperplasia approximately 1.0 mm from inked. superior margin. 3. Final posterior margin:. - Fibroadipose tissue and skeletal muscle, no tumor seen.
+
+--- Page 3 ---
+4. Final anterior and medial margin:. - Skin and subcutaneous tissue, no tumor seen.. (pT2 N0 Mx). Pathology Fellow: Pathologist(s): Electronically Signed By Pathologist Procedures/Addenda Addendum Date Ordered: Status: Date Complete: By: Date Reported: Addendum Diagnosis Immunohistochemistry stains for the sentinel lymph nodes (specimen #1) do not reveal metastatic carcinoma, comfirming the histologic diagnosis. These tests were developed and their performance characteristics determined by the immunohistochemistry laboratory at the These tests have not been cleared or approved by the U.S. Food. and Drug Administration. The FDA has determined that such clearance or. approval is not necessary. These tests are used for clinical purposes.. They should not be regarded as investigational or for research. This. laboratory is certified under the Clinical Laboratory Improvement Amendments of 1998 (CLIA) as qualified to perform high complexity clinical. testing. INVASIVE BREAST CANCER TEMPLATE: Excisions and Mastectomies Specimen Type Excision Lymph Node Sampling Sentinel lymph node(s) only Specimen Size (for excisions less than total mastectomy) Greatest dimension:9.0 cm
+
+--- Page 4 ---
+Laterality Right Tumor Site(s) Not specified Invasive Component  Solitary Greatest dimension: 3.0 cm Histologic Type(s) Invasive lobular Invasive Lobular Carcinoma Type Classical Solid Trabecular and Pleomorphic Invasion Invasion confined to breast parenchyma. Angiolymphatic Invasion Absent Intraductal Carcinoma Extensive intraductal component (EIC) [>25% of tumor mass and extending beyond edges of invasive carcinoma] Absent Lobular carcinoma in situ. Absent Margins Margin(s) involved by invasive carcinoma: lateral Regional Lymph Nodes 2 regional lymph nodes examined No regional lymph node metastasis histologically, no examination for isolated tumor cells (NO) Ancillary Immunopathology Studies (performed on ER Positive PR  Negative Her2-Neu 1+ pTNM: T2 N0 Mx
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diff --git a/output/text/358b22ad-f04d-4ad7-8b94-8ca952644230.txt b/output/text/358b22ad-f04d-4ad7-8b94-8ca952644230.txt
new file mode 100644
index 0000000000000000000000000000000000000000..34078f913e88eb394e6f16d9f6761abbf9c8f227
--- /dev/null
+++ b/output/text/358b22ad-f04d-4ad7-8b94-8ca952644230.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SURGICAL PATHOLOGY REPORT linical Diagnosis & History: year old male with history of colon carcinoma. Specimens Submitted: 1: terminal ileum, appendix, and ascending colon; Right hemicolectomy. DIAGNOSIS: TERMINAL ILEUM, APPENDIX, AND ASCENDING COLON; RIGHT 1. HEMICOLECTOMY : -TUMOR TYPE: ADENOCARCINOMA. - HISTOLOGIC GRADE: MODERATELY DIFFERENTIATED. TUMOR LOCATION: CECUM. TUMOR SIZE: LENGTH IS 4.5 CM WIDTH IS 4.0 CM MAXIMAL THICKNESS IS O.5 CM PREEXISTING POLYP (AT THE SITE OF THE CARCINOHA): TUBULOVILLOUS ADENOMA - TUMOR INVASION: INVASION INTO MUSCULARIS PROPRIA. SEROSAL INVOLVEMENT: NOT IDENEIFIED - VASCULAR INVASION: IDENTIFIED. PERINEURAL INVASION: NOT IDENTIFIED. - SURGICAL MARGINS : FREE OF TUMOR - POLYPS (AWAY FROM THE CARCINOMA) : NOT IDENTIFIED. -NON-NEOPLASTIC BOWEL: UNREMARKA - THE PATHOLOGIC STAGE IS (AUCC) pT2. LYMPH NODES: TWENTY-EIGHT BENIGN LYMPH NODES (0/28)  pNO. - THE PATHOLOGIC STAGE IS (AJCC I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER HATERIAL), AND THAT I HAVE REVIEWED AND APPROVED) THIS REPORT. *** Report Electronically Signed Out ** Gross Description: ** Continued on next page **
+
+--- Page 2 ---
+Page 2 of 2 1. The specimen is received fresh, labeled "Right hemicolectomy" and consists of a segment of terminal ileum, cecum with attached appendix and ascending colon. The terminal ileum measures 9,0 cm in length and 4.5 cm in circumference at the proximal resected margin. The remaining colon measures 18.5 cm in length with a circumference of 8.3 cm at the distal resected margin. The attached appendix measures 6.0 cm in length and averages 0.5 cm in diameter. The appendiceal and intestinal serosa is pink tan and smooth. Focally hemorrhagie lobulated yellow tan adipose tissue spans the length of the specimen measuring up to 4.0 cm in thickness. The specimen is opened to reveal a mass.  lesion in the cecum, 0.s cm distal to the ileocecal valve,. measuring 4.5 cm in length and 4.0 cm in width. Sectioning show that the tunor invades into the muscle wall. The depth of invasion is 0.5 cm grossly. The remaining mucosa is unremarkable. The specimen is submitted for iymph  node dissection. Multiple lymph nodes are identified in the attached adipose tissue and.are submitted. Representative sections of the specimen are submitted for permanent sections and tor Tps.. Summary of sections: P-- proximal margin shave. -. distal margin shave M-. mass A -- appendix representative sections. RS--representative sections BLN --* bisected lymph nodes LN-- lymph nodes Summary of Sections: texminal ileum, appendix, and ascending colon; Right hemicolectomy. Part 1: Sect. Site. PCs Block AP 3 1 2 BLN DM 1 LN 22 6 PM 1 1 1 6 6 ** End of Report **
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diff --git a/output/text/35ae4688-8240-4cdc-8bcf-1ca1d75e1212.txt b/output/text/35ae4688-8240-4cdc-8bcf-1ca1d75e1212.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9572c37eeec36638c32987fd763d7991da8ebb8e
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis: Partial (sigmoid) colon resection material with an ulcerated carcinoma of the colon characterized histologically as a moderately differentiated colorectal adenocarcinoma, showing circular growth in the intestinal wall over a length of 3.5 cm and extending to within 6 cm of a resection margin Invasive tumor spread within all parietal layers as far as the adjoining mesocolic fatty tissue.. Colon otherwise shows several pseudodiverticula and slight chronically scarring peridiverticulitis Oral and aboral resection margins tumor-free. One of 26 lymph nodes with a metastasis of the colon carcinoma not extending over the capsule.. Other lymph nodes with uncharacteristic reactive lesions. Tumor stage thus pT3 pN1 (1/26) L0 V0; G2 R0
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diff --git a/output/text/35cf474a-e50c-4507-a460-fd0002dd77a6.txt b/output/text/35cf474a-e50c-4507-a460-fd0002dd77a6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..798b8ea3cfc430fedc72d43e654ac86f3aba899a
--- /dev/null
+++ b/output/text/35cf474a-e50c-4507-a460-fd0002dd77a6.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID: 22C33C79-0791-40C1-A97C-F1C1AD76063E Redacted SURGICAL PATHOLOGY REVISED REPORT ICD Case Number : CsLntesi ssntn iIAitS S/46J3 Sute Siomudelom C18.7 Diagnosis: Os #h3/4 A: Colon, rectosigmoid junction, resection Tumor Histologic Type: invasive colonic adenocarcinoma (see. comment) Histologic Grade: low grade, grade 2 of 4 (moderately. differentiated) Tumor Size: 5.2 cm in diameter Tumor Location: sigmoid colon, just proximal to rectosigmoid junction Depth of Invasion: through muscularis propria and into. pericolonic soft tissues Lymphovascular Invasion: present Perineural Invasion: not identified Margins: Proximal margin: negative, 6.5 cm away Distal margin: negative, 5.0 cm away Mesenteric margin: negative Regional Lymph Nodes: Total number with metastases: 6 Total number examined: 24 Additional Pathologic Findings: none AJCc Pathologic TNM Stage: pT3 pN2a Note: This pathologic stage assessment is based on information available at the time of this report and is subject to change pending clinical review and additional information. Comment: Immunostains for mismatch repair protein expression are pending. The results will be issued as an addendum to this report. Materials will be submitted to the for microsatellite instability testing. These results will be issued
+
+--- Page 2 ---
+in a separate Molecular Pathology report.. Clinical History: -year-old male with a clinical diagnosis of colon cancer.. Gross Description: Received is one appropriately labeled container, additionally labeled "rectosigmoid junction, stitch is distal" and holds a 15 cm in length x 3.5 cm in open circumference segment of large. bowel oriented as stated above. The proximal mucosal margin is inked blue, the distal mucosal margin is inked black, and the tinea and surrounding yellow lobulated fat is inked green for identification purposes. Approximately 6.5 cm from the proximal mucosal margin and 5.0 cm from the distal mucosal margin, there is a 5.2 cm proximal to distal x 4.0 cm circumferential tan firm mass with central ulceration and raised edges.. The mass on section extends up to 1.2 cm through the muscularis propria into the attached yellow lobulated fat. The mass comes to within 0.8 cm from the yellow intact peritonealized surface. The mass is present at the rectosigmoid junction and is not. surrounded by mesorectum. No additional abnormalities are noted. Tumor and normal are submitted to tissue procurement.. Block Summary: Al - Proximal en face mucosal margin. A2-A3 - Distal en face mucosal margin. A4 - Mesenteric vascular pedicle margin. A5 - Lymph node present at mesenteric vascular pedicle margin, bisected A6-A7 - Mass with extension into fat. A8 - Mass with respect to tinea A9 - Additional section of mass with extension into fat A10 - One lymph node trisected Al1 - One lymph node, trisected A12-A13 - Multiple lymph nodes, each cassette. A14 - One lymph node bisected Al5-A16 - Multiple lymph nodes each cassette A17-A19 - One lymph node each cassette, each sectioned. Tissue remains in formalin. Addendum To add the results of immunostains Addendum Comment Immunostains for mismatch repair protein expression are performed on
+
+--- Page 3 ---
+block A8 and show normal expression of MLhl, Pms2, Msh2, and MSH6 within the tumor. Correlate with the results of microsatellite instability testing. lw1243 1 3
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diff --git a/output/text/35d29480-9d70-47eb-a7d3-bcd8d545fe79.txt b/output/text/35d29480-9d70-47eb-a7d3-bcd8d545fe79.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d57dd4074d3388b8ac37169d8361b08f200eac72
--- /dev/null
+++ b/output/text/35d29480-9d70-47eb-a7d3-bcd8d545fe79.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+Patient Name: Accession #: Med. Rec. #: Date of Procedure DOB: Date of Receipt Cander: Date of Repord Ref. Physician: Account #: Patient Address: Billing Type: Additional Copy to: Ref Source is & History: With right renal mass and caval thrombus. Specimens Submitted: 1: SP: Right kidney, renal vein thrombus, vena caval thrombus; radical nephrectomy 2 SP: Portion ol right gonadal vein; biopsy. 3: SP: Para caval and pre caval lynph nodes; excision.  4: $P: Right renal lymph nodes; excision. DIAGNOSIS: 1. SP: Right kidnoy, renal vein thrombus, vona caval thrombus; radical nephrectomy: Tumor Type: Renal cell carcinoma - Unclassified type with high nuclear grade; see note. Tumor Size: Greatesl diameter is 12.2 cm. Local Invasion (for renal cortical types). Involves renal sinus fat Involves ronal hllar fat Renal Vein Invasion: Identified Tumor is also seen in muscular veins in the region of the renal sinus/hilum Surgical Margins. Tumor present al renal vein margin.  Non-Neoplastic Kidney: Unremarkable Adrenal Gland: Not identified Lymph Nodes. Not identified Staging for renal cell carcinoma/oncocytoma:. pT3b Tumor grossly extends into the renal vein(s) or vena cava below the diaphragm Noto: The tumor displays predominant papillary and focally solid archilecture and is composed of cells with abundant eosinophilic cyloplasm and high nuclear grade, Immunohistochemical stains are strongly positive for racemase and CD10 (the lalter in a luminal" paltorn), show patchy positivity for CA-IX, and are negativo for CK7, 34BE12, TFE-3, TFE-B and CEA. The combination Page 1 of 4
+
+--- Page 2 ---
+ of these findings raises a differential diagn! cell carcinoma and a tumor ol distal nephron origin. This case has been reviewed wit? which concurs with the diagnosis.. 2. SP: Portion of right gonadal vein; biopsy: Benign segment of vascylar tissue. 3. SP: Para caval and pre caval lymph nodes; oxcision: Lymph Nodes: Not involved Number of nodes examined:11. SP: Right renal lymph nodes; excision: 1.ymph Nodes: A ganglioneurona (1. icn) and adjacent benign adrenal tissue are seen: no tymph nodes identified Somo of the immunohistochemistry and ISh tesls were developed and their performance charactoristics were detorminod by the Department o! Pathology. They have not been cleared or approved by the US Food and Orug Administration. Tho FDA has datermined that such clearance or. approval is not necessary. These tests are usad for clinical purposes. They should not ho renarded as invesligational or for research. Thns. Iaboralory is certified under the Clinical Lahoratory improvement Amondmonts 0 alilied to petonm high conplexity clinical laboratory losting TATTEST THAT THE ABOVE DIAGNOSIS IS BASEO UPON MY PERSONAL EXAMINATION OF THE SLIDES (ANDiOR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT Special Studies:. Result  Special Stain Comment CA-1X. CD10 RACEMASE CK7 CEA P 348E12 IMM RECUT NEG CONI IGH Gross Description: 1) The specimen is received fresh labeled "right kidney, renal vein thrombus, vena caval thrombus" and consists ol a xidney willh. allached ureter, renal vossels and perinephric fat weighing 526 g in total. The kidney measures 12.2 x 8.6 x 6.8 cm. The attached.  ureter measures 4.5 cm in length and 0.3 cm in diameter. The atlached renal vein measures 6.6 cm in length and 1.8 cm in  diameler, and is completely filled with tan, friable feshy lumor mass. The ureter margin is grossly unremarkable. The kidney is.  inked black and bivalved to reveal a 12.2 x 9.2 x 7.4 cm irregular lobulaled, friable tan tumor mass, comptelely replacing upper pole.  and mid kidney. The tumor grossly invades into the renal sinus and renal vein. Sections through the remainder of the kidney reveal a pink brown parenchyma, with a well-defined cortico-modul nclion. The cortex measures 0.6 cm. The specinen is photographed. Representative soctions are submitted for Id for permanont seclions. Summary of sections:.  RAM - renal artery margin. RVM -- ronal vein margin. UM -- ureteral margin Page 2 of 4
+
+--- Page 3 ---
+I.. tumor. RV -- senal vein THF-- tumor with hilum. TPF -- lumor to perirenal fat K -- representative section, unaffected kidney 2) The specimen is received in fornalin, labeled "portion of right gonadal vein" and consisls of a segment of vein measuring 2.1 cm  in length and 1.2 cm in average diameter. Summary of seclions:. M--margin U--representative section of remainder 3) The specimen is received in formalin, labeled "paracaval and precaval lymph nodes" and consists of mullipte pink tan firm lymph nodes ranging from 0.4  to 1.8 cm in grealest dimension. All identilied lymph nodes are submilled.. Summary of sections:. LN -- lymph nodes 8LN-- bisected lymph nodes 3.2 x 2.0 x 0.3 cm) with atlachod fat measuring 6 2 x 4.7 x 0.8 cm in overall dimension. Possible lymph nodes are als0 identified The specinnen is representativoly submitted. Summary ol sections: LN -- lymph nodes TLN-- trisected lyniph nodes ADR--adrenal gland F--fal Summary of Sections: Part 1: SP: Right kidney, renal vein thrombus, vena caval thrombus; radical nephrectomy. Block Sect. Site PCs 1 K 1 1 RAM 1 2 RV 2 1 RVM 1 8 T 8 3 THF 3 2 TPF 1 UM Part 2: SP: Portion of right gonadal vein; biopsy. Block Sect. Site PCs 1 m 1 1  Part 3:  SP: Para caval and pre caval lymph nodes; excision. Block Sect. Sito PCs 3 bin 3 3 In 3 Part 4: SP: Right renal lymph nodes; excision. Page 3 of 4
+
+--- Page 4 ---
+Blocke Sect. Site. PCs 1 adr 1 1 1 13 1 tIn Page 4 of 4 END OF REPORT
\ No newline at end of file
diff --git a/output/text/35ecb5fa-9687-4a0a-a558-c9bc599424e7.txt b/output/text/35ecb5fa-9687-4a0a-a558-c9bc599424e7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d8c5d5aa952737c06a38402255c5a805fcf25910
--- /dev/null
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@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+ciinical Diagnosis & History: /o female with left breast mass. Mammo showed 2 lesions in u0Q left. breast. Core biopsies IDc and Dcis. Proceeding to MRM. Specimens Submitted: 1: sp: Left breast with level 1 and low level 2 axillary contents 2: Sp: Additional level 2 left axillary contents 3: Sp: Left level 2 and level 3 axillary contents DIAGNOSIS: UUID:C2976F78-89AF-4461-8D22-BFE8C0504722 BREAST WITH LEVEL I AND LOW LEVEL II AXILLARY CONTENTS, LEFT; TCGA-AO-A03L-01A-PR 1) Redacted MODIFIED RADICAL MASTECTOMY AND AXILLARY LYMPH NODE DISSECTION: - TWO SEPARATE TUMOR NODULES: ONE IS LOCATED IN THE UPPER OUTER QUADRANT AND SHOWS AN INVASIVE DUCTAL CARCINOMA, POORLY DIFFERENTIATED (HISTOLOGIC GRADE III/III, NUCLEAR GRADE III/III). MEASURING 3.9 CM IN LARGEST DIMENSION GROSSLY. THE SECOND IS LOCATED IN THE UPPER AND LOWER OUTER QUADRANTS AT 3:OO AND ISS COMPOSED OF PRKDOMINANTLY DUCTAL CARCINOMA IN SITU (DCIS) WITH SEVERAL FOCI OF INVASIVE DUCTAL CARCINOMA, POORLY DIFFERENTIATED AND SIMILAR TO ABOVE, RANGING IN SIZE FROM LESS THAN O.1 CM TO ABOUT O.4 CM. THE DUCTAL CARCINOMA IN SITU (DCIS) IS OF THE SOLID AND CRIBRIFORM TYPES WITH HIGH NUCLEAR GRADE, EXTENSIVE NECROSIS AND FOCALLY INVOLVES A LARGE LACTIFEROUS DUCT OF THE NIPPLE. - CALCIFICATIONS ARE PRESENT IN THE IN SITU AND INVASIVE CARCINOMA, AND INS BENIGN BREAST PARENCHYMA. . VASCULAR INVASION IS PRESENT. - NO INVOLVEMENT OF THE SURGICAL MARGINS BY EITHER INVASIVE OR IN SITU CARCINOMA IS IDENTIFIED. -NO SKIN INVOLVEMENT BY CARCINOMA IS IDENTIFIED. THE REMAINING BREAST TISSUE SHOWS PREVIOUS BIOPSY SITE AND MILDS FIBROCYSTIC CHANGES. - THE LYMPH NODE STATUS IS AS FOLLOWS (EXPRESSED AS THE NUMBER OF POSITIVE) LYMPH NODES IN RELATION TO THE TOTAL NUMBER OF LYMPH NODES BXAMINED): THERE IS BXTRANODAL TUMOR EXTENSION (>2 MM). - RESULTS OF IMMUNOHISTOCHEMICAL STAINS ARE AS FOLLOWS: ER: 0% NUCLEAR STAINING PR: 0% NUCLEAR STAINING HER-2/NEU (HERCEPTEST) : NEGATIVE (STAINING INTENSITY OF 1+) Ics-0-3 ++ Continued on next page ** Chuuiomr nfittnatnj duct,nvs 85cyj3 Site: hrut,nos cso.9 10/22/n
+
+--- Page 2 ---
+2) AXILLARY CONTENTS, LEFT ADDITIONAL LEVEL II; DISSECTION TWELVE BENIGN LYMPH NODES (0/12). AXILLARY CONTENTS, LEFT LEVELS II AND III; DISSECTION: THREE BENIGN LYMPH NODES (0/3). I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL). AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. *** Report Blectronically Signed Out ***. Special Studies: Result Special Stain Comment ER-C pr-c HER2-C NEG CONT IMM RECUT NEG-HER2 Gross Description: 1) The specimen is received fresh labeled, "Left breast with level 1 and. low level 2 axillary contents, stitch marks axillary contents" and consists of a breast with attached axillary tail. The breast measures 37.0 x 26.0 x 6.7 cm with overlying skin ellipse measuring 36.5 x 18.0 cm...  Situated ons the skin surface is an everted nipple measuring 1.4 x 1.2 x 0.1 cm and areola measuring 4.8 x 4.5 cm. The skin shows no visible scars.. A suture demarcates the axillary tail which measures 1l.0 x 4.0 x 3.5 cm. posterior surfaca of the breast is inked black and the specimen is serially The Sectioned to reveal a white tan firm ill-defined mass in the upper outer quadrant measuring 3.9 x 3.7 x 3.3 cm, located 1.5 from the deep margin. There is a biopsy site identified in the lower outer quadrant, corresponding to the three o'ciock position, measuring 2.0 x 2.0 x 1.5 cm.. The remaining breast tissue shows predominantly yellow lobulated adipose tissue admixed with white-tan fibrous soft tissue with no other gross identifiable lesions. The axillary tissue is dissected to reveal several grossly positive lymph nodes, measuring up to 4.5 cm. Representative sections of the mastectomy. specimen and ali identified axillary lymph nodes are submitted (the large grossly positive lymph nodes are representatively submitted). Tissue is taken for Tps. Sumnary of sections: N - nipple NB - nipple base D deep margin tumor ** Continued on next page **
+
+--- Page 3 ---
+BX separate biopsy site UIQ  - upper inner quadrant 4IQ lewer inner quadrant UOQ upper outer quadrant LOQ lower outer quadrant LN individual lymph nodes The specimen is received in formalin, labeled "Additional level 2 2 left axillary contents" and consists of an axillary dissection measuring 7 x 4.5 x 0.8 cm.  The specimen consists of soft yellow-tan lobulated tissue with several pink-tan lymph nodes identified on cut section ranging from 0.2 cm to 1.8 cm in greatest dimension. The specimen is submitted for lymph node digest dissection. Sumnary of sections: LN - lymph nodes 3) The specimen is received in formalin, labeled *Left level 2 and level 3 axillary contents" and consists of an unoriented axillary dissection measuring 7.5 x 4.7 x 1.8 cm.  The specimen consists of yellow tan lobulated tissue, which on sectioning reveals several pink-tan lymph nodes ranging from 0.2 cm to 2.3 cm in greatest dimension. The specimen is submitted for lymph node dissection. Summary of sections: LN - lymph nodes Summary of Sections: Part 1:  SP: Left breast with level 1 and low level 2 axillary contents Block Sect. Site PCs 3 BX 3 1 D 1 2 LIQ 2 4 LN 4 LOQ H d H m N NB 1 s H 1 22 UIQ 2 UOQ 2 Part 2: Sp: Additional level 2 left axillary contents PCs Block Sect. Site.
+
+--- Page 4 ---
+LN 3:. SP: Left level 2 and level 3 axillary Block Sect. Site PCs LN End of Report
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diff --git a/output/text/361b5d8b-d617-4c93-b04a-0992d6376956.txt b/output/text/361b5d8b-d617-4c93-b04a-0992d6376956.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0c729ef54cdde53f98966e0d637a5373a2e4259a
--- /dev/null
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@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+ADUENDUM UUID:A8AF94A0-F3C2-4AB0-AB0C-22BDA51AF546 'TCGA-AO-A03U-01A-PR Redacted Clinical Diagnosis and History: Patient with left breast mass.  Core biopsy IFDc for TM/SLN bicpsy right mastectomy to be performed prophylactically. Specimens Submitted: 1: SP: Sentinel node #1, level 1, lt. axilla (fs) 2 SP: Sentinel node #2, level 1, 1t. axilla (fs) : 3 SP: Sentinel node #3. level 2, lt. axilla (fs) 4: SP: Lt. breast 5: SP: Right breast 6: SP: J  Non-sentinel noae seft axilla 7: SP:  Sentinel node #1,rt. axilla DIAGNOSIS: 1) LYMPH NODE, SENTINEL #1, LEVEL I, LEFT AXILLA; BIOPSY: - ONE BENIGN LYMPH NODE (O/1). DEEPER LEVEL RECUTS AND SPECIAL STAINS HAVE BEEN ORDERED. THE RESULTS WILL BE REPORTED IN AN ADDENDUM. 2) LYMPH NODES, SENTINEL #2, LEVEL I, LEFT AXILLA; BIOPSY: - FOUR BENIGN LYMPH NODES (O/4). DEEPER LEVEL RECUTS AND SPECIAL STAINS HAVE BEEN ORDERED. THE RESULTS WILL BE REPORTED IN AN ADDENDUM. 3) LYMPH NODE, SENTINEL #3, LEVEL II, LEFT AXILLA; BIOPSY: - ONE BENIGN LYMPH NODE (O/1). SPECIAL STAINS HAVE BEEN ORDERED. THE RESULTS WILL BE .DEEPER LEVEL RECUTS AND REPORTED IN AN ADDENDUM. BREAST, LEFT; MASTECTOMY: - INVASIVE DUCTAL CARCINOMA, SECRETORY TYPE, MEASURING 1.8S CM IN LARGEST DIMENSION MICROSCOPICALLY. - DUCTAL CARCINOMA IN SITU (DCIS) IS ALSO IDENTIFIED, ALSO SECRETORY TYPE. THE DCIS CONSTITUTES >= 25% OF THE TOTAL TUMOR MASS, AND IS PRESENT ADMIXED WITH AND AWAY FROM THE INVASIVE COMPONENT. - THE INVASIVE CARCINOMA IS LOCATED IN THE CENTRAL AREA. THE DCIS IS LOCATED IN THE LOWER OUTER QUADRANT, LOWER INNERS QUADRANT AND CENTRAL AREA. - NO INVOLVEMENT OF THE NIPPLE BY BITHER IN SITU OR INVASIVES CARCINOMA IS IDENTIFIED. - NO CALCIFICATIONS ARE IDENTIFIED IN EITHER THE INVASIVE ORS PATH ** Continued on next page ** REPORT 11 Ics-0 - 3 carcuioma,nifiltrsfrg stretory typc 8503/3 Sih: buat, Nos c50.9 10/211
+
+--- Page 2 ---
+IN SITU CARCINOMA. - NO VASCULAR INVASION IS NOTED. NO INVOLVEMENT OF THE SURGICAL MARGINS BY BITHER INVASIVES OR IN SITU CARCINOMA IS IDENTIFIED. - NO SKIN INVOLVEMENT BY CARCINOMA IS IDENTIFIED.S  THE NON-NEOPLASTIC BREAST TISSUE SHOWS FIBROADENOMATOID CHANGES. - RESULTS OF SPECIAL STAINS (ER, PR, HER2-NEU) WILL BE) REPORTED AS AN ADDENDUM. 5) BREAST, RIGHT; MASTECTOMY:S - BENIGN BREAST TISSUE WITH ADENOSIS AND FOCAL DUCTAL HYPERPLASIA WITHOUT ATYPIA. 6) LYMPH NODES, NON-SENTINEL, LEFT AXILLA; BIOPSY: - TWO BENIGN LYMPH NODES (O/2). 7) LYMPH NODE, SENTINEL #1, RIGHT AXILLA; BIOPSY: - ONE BENIGN LYMPH NODE (O/1). DEEPER LEVEL RECUTS AND SPECIAL STAINS HAVE BEEN ORDERED.  THE RESULTS WILL BE REPORTED IN AN ADDENDUM. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL). AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Special Studies: Stain/Procedure Name Result Comment KERATIN (CAM5.2) NEGATIVE AE1:AB3  NEGATIVE  NEGATIVE CONTROL IMMUNO RECUT KERATIN (CAM5.2) NEGATIVE AE1:AE3  NEGATIVE  NEGATIVE CONTROL IMMUNO RECUT KERATIN (CAM5.2)  NEGATIVE AE1:AE3  NEGATIVE NEGATIVE CONTROL IMMUNO RECUT KERATIN (CAM5.2) NEGATIVE AE1:AE3 NEGATIVE NEGATIVE CONTROL IMMUNO RECUT RECUT ADDITIONAL HE ESTROGEN RECEPTOR NEGATIVE PROGESTERONE RECEPTOR  NEGATIVE PATH REPORT ** Continued on next page. 11
+
+--- Page 3 ---
+heR2-C  NEGATIVE  NEGATIVE CONTROL FOR HER2  NEGATIVE CONTROL IMMUNO RECUT RECUT ADDITIONAL HE RECUT ADDITIONAL HE RECUT ADDITIONAL HE KERATIN (CAM5.2) NEGATIVE AE1:AE3 NEGATIVES  NEGATIVE CONTROL IMMUNO RECUT Gross Des 1 The specimen is received fresh for frozen section, labeled node measuring 1 x 0.8 x 0.5 cm. The node is bisected and. submitted entirely in one cassette. Summary of Sections: FSC - f frozen section control 2) The specimen is received fresh for frozen section, labeled. "Sentinel Node #2 Level 1 Left Axilla". It consists of a single. piece of adipose tissue measuring 4 x 4 x 2 cm. Serial. sectioning of the specimen reveals multiple lymph nodes ranging from 0.3 up to 0.5 cm in greatest dimension. The lymph nodes are submitted in two cassettes.. Summary of Sections: FsCA-b - frozen section controls A and B 3) The specimen is received fresh for frozen section, labeled "Sentinel Node #3 Level 2 Left Axilla". node and adipose tissue. The lymph node measures 2.2 x 1 x 0.6 It consists of a lymph cm. The node is submitted in one cassette. Summary of Sections: Fsc - frozen section control. 4) The specimen is received fresh, labeled "Left Breast. specimen measuring 22 x 22 x 5.2 cm. It has an attached ellipse of skin measuring 19.5 x 9.7 cm with a central nipple measuring  PATH REPORT ** Continued on next page **. 11
+
+--- Page 4 ---
+1.0 cm in diameter and o.4 cm in height.. The skin, nipple and areola are grossly unremarkable..  The specimen is serially sectioned to reveal in the central area, a 1.8 x 1.7 x l.5 cm ill-defined, firm, white nodule. The nodule is located within 2.0.cm from the closest deep margin and was seen 1.0 cm from the nipple. The remaining breast tissue shows few areas of fibrosis.. Representative sections are submitted. Summary of Sections: T - tumor DM -  deep margin, close to tumor uo - upper : outer quadrant LO - lower outer quadrant LI lower inner  quadrant inner  quadrant N - nipple NB - nipple base - skin S 5) The specimen is received fresh, labeled "Right breast (suture. marks axillary tail)". It consists of a total mastectomy. specimen. 21 x 20.5 x 4.5 cm. A skin is attached inferiorly, 19 x 8 cm. A nipple is present in the center of the skin, 1.3 cm in diameter. A biack suture labeled the axillary tail is present. The anterior aspect is inked in yellow and the posterior aspect is inked in black. Serially sectioned identifies the fibrotic area underneath the areola, 3.5 x 3.5 x 3 cm and another fibrotic area with blue dye, 4.5 x 3.5 x 3 cm.. No, otherwise, apparent tumor nodule is identified. Representative submitted in 20 cassettes. sections are Summary of Sections: - nipple s - skin DM . deep margin. F - fibrotic area D - blue dyed area ML - medial lower quadrant MU - medial upper quadrant LL - lateral iower quadrant LU  lateral  upper quadrant 6) The specimen is received in formalin, labeled "Non-sentinel Node Left Axilla". It consists of a single piece of adipose tissue measuring 2.5 x 2 x 1 cm.  Serial sectioning of the specimen reveals two rubbery lymph nodes measuring from 0.5 up to 1' cm in greatest dimension. The lymph nodes are submitted in one. cassette. Surmary of Sections: PATH REPORT * Continued on next page ** 11
+
+--- Page 5 ---
+LN  lymph nodes 7) .The specimen is received in formalin, labeled nSentinel Node #1 Right Axilla". It consists of a single piece of adipose. tissue measuring 3 x 2 x 1 cm. Serial sectioning of the specimen reveals a rubbery lymph node measuring 1.5 x 1 x 0.6 cm.. node is bisected. The cut surface of the node is pink to light The brown. It is submitted in one cassette.. Summary of Sections: LN - lymph nodes Surmary of Sections: Part Sect. Site Blocks Pieces 1 A11 Fsc 1 2 2 Y FSA 1 2 FSB 1 2 3 FSC 1 1 N 4 DM 1 1 LI N 2 LO 2 M N 1 m NB 1 1 S 1 1 T 4 M UI 2 M uo 2 M 5 d 5 dm 2 2 f 3 11 2 lu 2 m1 2 mu 2 2 n H 8 1 6 LN 1 LN N 7 1 N Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the. tissue sample examined at the time of the intraoperative consultation.. 1) PROZEN SECTION DIAGNOSIS: BENIGN. PERMANENT DIAGNOSIS: SAME. 2) FROZEN SECTION DIAGNOSIS: BENIGN. PERMANENT DIAGNOSIS: SAME. 3) FROZEN SECTION DIAGNOSIS:  BENIGN. PERMANENT DIAGNOSIS: SAME. PATH REPORT ** Continued on next page 11
+
+--- Page 6 ---
+ADDENDUM: ** SIGNED OUT ADDENDUM REPORT SITE: SENTINEL LYMPH NODES, RIGHT AND LEFT AXILLA PARTS #1,2,3,7. ADDITIONAL HE STAINED SECTIONS AND IMMUNOHISTOCHEMICAL STAINS FOR CYTOKERATINS (AE1:AE3 AND CAM 5.2) SHOW NO EVIDENCE OP METASTATIC TUMOR. ADDENDUM REPORT SITE: 4 LEFT BREAST ER-ICA: NEGATIVE PR-ICA:  NEGATIVE HER2/NEU (HERCEPTEST) : NEGATIVE (STAINING INTENSITY OF O). CONTROLS ARE SATISFACTORY. Report Blectronically Signed Out PATH ** Bnd of Report * REPORT 11
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diff --git a/output/text/36552b4c-c442-4f3e-a6e0-4c330d53274e.txt b/output/text/36552b4c-c442-4f3e-a6e0-4c330d53274e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6b7ccfb3e6b9bdd8a77886de402a4f00d5707fea
--- /dev/null
+++ b/output/text/36552b4c-c442-4f3e-a6e0-4c330d53274e.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TQDO-j tuleer eLcenome iislolneg s ductel ensiti UUID:A9015F6A-F6BB-4AC8-B681-099232A6DFAC D 8522/3 TCGA-AR-A5QN-01A-PR Redacted C6CF Cobul acuntmo  Brast 85Q0 i3 Site. 4oS Cs0.9 O 4/2|13 A. Lymph nodes, left tracheoesophageal groove, excision: Multiple (3) lymph nodes are negative for tumor. B. Thyroid, left, total lobectomy: Follicular adenoma (3.3 x 3.2 x 1.8 cm). C. Breast, right, simple mastectomy: Fibroadenoma measuring 0.7 x 0.6 x 0.5 cm at the previous. biopsy site in the upper outer quadrant. Remainder shows non-proliferative fibrocystic changes. Multiple (2) right axillary lymph nodes are negative for tumor. D. Breast, left, inferior flap, biopsy: Negative for tumor. E. Breast, left, inferior margin at 6 o'clock, excision: Involved by carcinoma. F. Breast, left, new inferior margin, re-excision: Negative for tumor. G. Breast, left, modified radical mastectomy: Invasive lobular carcinoma, Nottingham grade II (of III), [tubules 3/3, nuclei 2/3, mitoses 1/3; Nottingham score 6/9], forming multiple (6) masses. (lower inner quadrant, 0.7 x 0.6 x 0.4 cm and 1.4 x 1.0 x 0.5 cm; inferior/central, 3.2 x 2.2 x 1.4 cm; central, 0.6 x 0.5 x 0.5 cm; lower outer quadrant, 1.0 x 0.8 x 0.8 cm and 0.5 x 0.4 x 0.4 cm) in the left breast. Ductal carcinoma in situ and lobular carcinoma in situ are present. The non- neoplastic breast parenchyma shows nonproliferative fibrocystic changes. A second core biopsy site is present in the upper outer quadrant which shows biopsy site changes. The tumor does not involve the nipple, overlying skin, or underlying chest wall. Dermal nevus forming a 1.5 x 1.3 x 0.3 cm raised, brown, pigmented lesion on the lateral aspect of the skin. All surgical resection margins, after multiple (2) re-excisions of the inferior margin (see parts E and F), are negative for. invasive carcinoma by 1.2 cm, deep margin. Multiple (10 of 19) left axillary lymph nodes are positive for metastatic carcinoma. The largest metastasis measures 11.0 mm. Extranodal extension is not present. MIB-1 has been ordered on paraffin-embedded tissue. This final pathology report is based on the gross/macroscopic examination and the frozen section. histologic evaluation of the specimen(s). Hematoxylin and Eosin (H&E) permanent sections are reviewed to confirm these findings. Any substantive changes identified on permanent section review will be retlected in a revised report. 38+3
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diff --git a/output/text/3659a5bb-f284-4936-851a-37b9ce269ef7.txt b/output/text/3659a5bb-f284-4936-851a-37b9ce269ef7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b430cfa939f83eeed8e1c85eb93d1f5229140a01
--- /dev/null
+++ b/output/text/3659a5bb-f284-4936-851a-37b9ce269ef7.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SPECIMENS: A. RIGHT COLON & TERMINAL ILEUM DIAGNOSIS: RIGHT COLON AND TERMINAL ILEUM, RESECTION (RIGHT HEMICOLECTOMY SPECIMEN): EXOPHYTIC INVASIVE MODERATELY DIFFERENTIATED ADENOCARCINOMA ARISING FROM TUBULOVILLOUS ADENOMA OF TRANSVERSE COLON WITH FULL MUSCLE WALL THICKNESS INVASION, EXTENSION TO SUBSEROSAL FAT AND METASTASES TO ONE OUT OF TWENTY SIX PERICOLIC LYMPH NODES (1/26). -SIZE OF TUMOR - 5.5x3.5x1.0 cm. -PROXIMAL, DISTAL AND RADIAL MARGINS OF RESECTION - FREE OF TUMOR. -APPENDIX - NO SPECIFIC PATHOLOGIC CHANGES - NEGATIVE FOR TUMOR. -PORTION OF OMENTAL FAT - NO SPECIFIC PATHOLOGIC CHANGES. GI Cancer Template Tumor Size (cm): 5.5x3.5x1.0 cm. Grade/Differentiation: G2 moderate Invasion Depth: Subserosa (not to perit. Surface) Invasion Vasc/Lymphatic: absent Invasion Perineural: absent Extension to adjacent areas: no Margins: free. Lymph nodes: N1=Positive (1/26) Stage, Pathology: pT3 N1 Implants: absent Precursor: present - tubulovillous adenoma Non-neoplastic areas: NA SPECIMEN(S): A. RIGHT COLON & TERMINAL ILEUM CLINICAL HISTORY: Colon ca. GROSS DESCRIPTION: RIGHT COLON AND TERMINAL ILEUM, RESECTION: A right hemicolectomy specimen comprised of cecum, ascending and transverse colon and appendix and short segment of terminal ileum. Colon measures 34 cm in length and with internal circumference of 7-9 cm. Short segment of terminal ileum measures 3.5 cm in length. Situtated 5.5 cm from the distal resected margin (transverse colon area) 32 cm from proximal margin is a fungating tumor that occupies 80% of the mucosal circumference. The tumor measures 5.5x3.5x1.0 cm. On sections, tumor grossly infiltrates muscle wall without gross extension to subserosal fat.. Remainder of colonic mucosa is grossly not remarkable. There is no identifiable polyps or diverticuli.. Cecum is not remarkable. Appendix measures 11 cm in length and external diameter of 0.5 cm. Grossly, appendix is not. remarkable Attached portion of omentum measures 8x7x0.9 cm. Cut section shows no indurated focus. Approximately 5 lymph nodes are dissected ranging in size from 0.1 cm to 1x0.5x0.6 cm. Multiple sections submitted as follows: A1-A5: tumor A6: proximal ileal margin A7; distal colonic margin A8: representative section of colonic mucosa distal to the tumor A9: representative section of colonic mucosa proximal to the tumor and ileocecal valve. A11: four lymph nodes from portion near tumor A12: four lymph nodes from portion near tumor A13: four lymph nodes from portion near tumor
+
+--- Page 2 ---
+A14: one serially sectioned lymph node from portion near tumor A15: five lymph nodes from middle portion of colon A16: five lymph nodes from middle portion of colon A17: one serially sectioned lymph node from middle portion of colon A18: five lymph nodes from ileocecal junction A19: six lymph nodes from ileocecal junction ADDENDUM: ANALYSIS OF MLH1 AND MSH2 PROTEIN EXPRESSION MLH1 Expression: Present MSH2 Expression: Present Tissue from this patient was retrieved from the archive and analyzed for these tumor markers.. Expression of MLH1 and MSH2 in the tumor was evaluated by immunohistochemistry. Peritumoral lymphocytes serve as an internal positive control expressing both MLH1 and MSH2.. Testing for Microsatellite Instability has been ordered. The results will be issued in a separate report.
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diff --git a/output/text/365bb740-b236-403e-b514-d8d59f875787.txt b/output/text/365bb740-b236-403e-b514-d8d59f875787.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8481a28f65dbdea613f16b333a216f466d7e4d6b
--- /dev/null
+++ b/output/text/365bb740-b236-403e-b514-d8d59f875787.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID: 9A99C0B-87F4-4E91-A80F-7F9AAB884CBF TCGA-WS-AB45-01A-PR  Redacted SURGICAL PATHOLOGY REPORT  NAME: SURG PATH #: MR #: SPECIMEN CLASS: BILLING #: ALT ID #: LOCATION: DATE OF PROCEDURE: AGE: SEX: F DATE RECEIVED: DOB: TIME RECEIVED: PHYSICIAN: DATE OF REPORT: COPY TO: DATE OF PRINTING: Procedures/Addenda Addendum Date Ordered: Status:  Signed Out Date Complete: By: Date Reported: Addendum Diagnosis. Specimen A: This addendum is issued to clarify the status of the circumferential margin on the previously issued checklist. The adenocarcinoma is within 0.05 cm of the apparent serosal surface, not the circumferential margin. The remaining diagnosis remains unchanged. Addendum Comment {Not Entered} CD-O olvizCarevnirr, muc irois NoS 848cf3 <349013 Material Received: 54803 Csole te Jugyhust 8490/3 A: tumor Site: C eeum. C18.O History: A  -year-old female with a clinical history of right colon cancer. Y 5/80/4 Final Diagnosis: A. Right colonic segment, terminal ileal segment, appendix and pericolic lymph nodes (13), "tumor", right hemicolectomy: Mucinous adenocarcinoma, signet ring cell type, extending extensively into subserosal tissue. See comment. Pericolic lymph nodes: There is no evidence of malignancy (0/13). Comment: Colectomy Specimen Type: Right hemicolectomy Tumor Site: Cecum Gross Configuration:  Exophytic, Ulcerating Tumor Size: 7.0 x 7.0 x 5.0 cm MR #: Page 1 of 3 Date of Printing: SURGICAL PATHOLOGY REPORT Order Number:
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT NAME: SURG PATH #: MR #: ALT ID #: Histologic Type: Mucinous adenocarcinoma, signet ring cell type. Histologic Grade: Moderately to poorly Pre-existing Polyp: Not identified Surgical Margins: Negative for carcinoma Proximal Margin: 4.5 cm from carcinoma Distal Margin: 5.5 cm from carcinoma Distance of invasive carcinoma from closest margin: Less than 0.05cm  Specify margin: Circumferential (Radial) margin. Depth of Invasion: Subserosal tissue Perforation: No. Obstruction: Yes Vascular Invasion: Not identified Perineural Invasion: Not identified Tumor Border Configuration: Pushing Additional Pathologic Findings: Hyperplastic polyp. Lymph Nodes: Number Examined: 13 Number Involved: 0 Prognostic Markers: See for addendum : No (Sample was sent for analysis by  instead) Gross Picture Taken: No Pathologic Staging (pTNM): pT3N0Mx Primary Tumor (pT) pT3: ' Tumor invades through the muscularis propria into the subserosa or the nonperitonealized pericolic or perirectal soft tissues Regional Lymph Nodes (pN) pNO: No regional lymph node metastasis. Distant Metastasis (pM) pMX: Cannot be assessed The pathologic stage assigned here should be regarded as provisional, as it reflects only current pathologic data and does not  incorporate full knowledge of the patient's clinical status and/or prior pathology.. Immunostains for the following cytokeratins (pan-cytokeratin, CAM 5.2 and OSCAR) performed on selected lymph node sections are negative consistent with the above diagnosis.. Attestation: By this signature, I attest that I have personally formulated the final interpretation expressed in this report and that the above diagnosis is based  upon my examination of the slides and/or other material indicated in this report. ***Electronically Signed Out By**** Interpreted by: Gross Description: A. Received fresh and subsequently placed in formalin labeled with the patient's name and "tumor's is a 14.0 cm colectomy specimen with a diameter of 4.5 cm and two stapled margins. The specimen is opened along the antimesenteric site to reveal a large friable fungating mass measuring 7.0 x 7.0 x 5.0 cm, filling the cecum.. The mass is 5.5 cm from the distal rection margin and 4.5 cm from the proximal resection margin..  The mass appears to be circumferential and due to the size of the mass, distorts. the specimen. There is an attached appendix, 10.0 cm in length with an average diameter of 0.7 cm.. The appendix is serially. sectioned revealing a 0.2 cm lumen filled with brown soft fecal material..  The appendix does not appear to be involved by the mass.  The appendiceal orifice is inked green. The distal margin is marked by a suture and is inked blue.. The pericolonic fat deep to the mass is inked black. The mass is sectioned to reveal an average thickness of 0.9 cm. The mass appears to extend. through the submucosal and into the wall. The mass focally replaces the wall and extends into the pericolonic fat.. The remainder of the mucosa is tan-pink with mucosal folds arranged in the usual manner, however, there is a 0.7 x 0.7 x 0.3 cm tan-pink polyp that. is 1.0 cm from the blue inked distal resection margin. Sectioning of the pericolonic fat reveals 13 possible lymph nodes ranging in size from 0.3 x 0.3 x 0.3 cm to 1.3 x 1.2 x 1.0 cm. The remainder of the pericolonic fat is unremarkable. MR #: Page 2 of 3 Date of Printing: SURGICAL PATHOLOGY REPORT
+
+--- Page 3 ---
+SURGICAL PATHOLOGY REPORT NAME: SURG PATH #: MR #: ALT ID #: A portion of the mass is submitted in cassettes A1FS for frozen and permanent section.  The remainder of the specimen is submitted as follows: A2 - Small polyp 1.0 cm from the distal margin.. A3 - Distal 1/3 of the appendix. A4 - Middle 1/3 of the appendix. A5 - Proximal 1/3 of the appendix, green ink indicates appendiceal orifice. A6 - Distal resection margin, parallel. A7 - Proximal resection margin, parallel.. A8 through A11-  Representative section of mass including deepest invasion. A12 - Unremarkable mucosa. A13 - One apparent lymph node, trisected and submitted in its entirety. A14 - One apparent lymph node, bisected in its entirety.. A15 - One apparent lymph node, bisected in its entirety. A16 - One apparent lymph node, bisected in its entirety. A17 - Two apparent lymph nodes, each bisected and one is inked black and one is uninked.. A18 - Two apparent lymp nodes, each bisected and one is uninked and one is inked black.. A19 - Two apparent lymph nodes, each bisected and one is uninkd and one is inked black.. A20 - Two apparent lymp nodes, each bisected and one is inked black and ine is uninked.. A21 - One lymph node in its entirety. A22-A31 Additional sections from the tumor mass Intraoperative Consultation: A1FS, "tumor": Adenocarcinoma with abundant mucin and necrosis. Sections sent for testing. The proximal and distal margins are grossly free of cancer. If immunohistochemical stains and/or in situ hybridization are cited in this report, the performance characteristics were determined by the  in compliance with CLiA'88 regulations. Some of these tests rely on the use of "analyte specific reagents" and are subject to specific labeling requirements by the FDA. Known positive and negative control tissues demonstrate appropriate staining. This testing was developed by the It has not been cleared or approved by the FDA. The FDA has determined that such clearance or approval is not necessary. H18|14 MR #: Page 3 of 3 Date of Printing: SURGICAL PATHOLOGY REPORT
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diff --git a/output/text/3665b793-bed7-474b-a489-81ffc030ccf8.txt b/output/text/3665b793-bed7-474b-a489-81ffc030ccf8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fc218ed3a297ffde8696f9617a6380d2ed7a8c6c
--- /dev/null
+++ b/output/text/3665b793-bed7-474b-a489-81ffc030ccf8.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:3971CA42-F1B0-4D85-9AD3-210898E76A9C FO1 TCGA-A2-A25A-01A-PR Redacted SURGICAL PATHOLOGY REPORT Patient: FMP/SSN: Specimen #: DOb/Age/Sex: Age: I Rare: Location: Taken: Physician(s) : Received: Reported: **AMENDED** 1cL-0-3 SPECIMEN: Carcinona, nfitrathg 1obula, N0S A: LEFT BREAST MASTECTOMY B: RIGHT BREAST 85Q0f3 Sit: srust Nos c5o.9 hw 4/27/ FINAL DIAGNOSIS: A. BREAST, LEFT, MASTECTOMY: MODERATELY DIFFERENTIATED INFILTRATING LOBULAR CARCINOMA WITH LOBULAR CARCINOMA IN SITU, EXTENDING INTO THE MILK DUCTS AND SKIN OF THE NIPPLE AND INVOLVING THE UPPER OUTER QUADRENT, AND EXTENDING WITHIN IMM OF (BUT NOT INVOLVING) THE DEEP SURGICAL MARGIN. ATYPICAL LOBULAR HYPERPLASIA INVOLVING THE LOWER INNER QUADRANT AND LOWER OUTER QUADRANT. B. BREAST, RIGHT, MASTECTOMY: - LOBULAR CARCINOMA IN SITU (IMM) WITH EXTENSIVE LOBULAR HYPERPLASIA. ATYPICAL LOBULAR HYPERPLASIA. - FIBROCYSTIC CHANGES INCLUDING CYSTS, FIBROSIS, AND APOCRINE METAPLASIA. COMMENT #1: ESTROGEN RECEPTORS:NEGATIVE PROGESTERONE RECEPTORS: POSITIVE (80-9O% OF NUCLEAR SUTAINING) COMMENT #2: HER2/NEU (FISH METHODOLOGY): NOT AMPLIFIED (1.1) ** Report Electronicallv Sianed Out ** CLINICAL DIAGNOSIS AND HISTORY: -year-old with left infiltrating lobular carcinoma by biopsy. Scheduled for bilateral mastectomy and left sentinel node biopsy. PRE-OPERATIVE DIAGNOSIS: Left breast carcinoma. Page 1 FOR OFFICIAL USB ONLY - PERSONAL DATA - PRIVACY ACT OP 1974 Continued on Next Page
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION: A. LEFT BREAST MASTECTOMY received fresh is a 243.0 gram simple mastectomy specimen, 15.5 x 15.0 x 3.3 cm, with overlying ellipse of nipple bearing skin, 4.8 x 3.3 cm. The skin and nipple are unremarkable. The specimen is oriented with sutures (long=lateral, short=superior) and inked as follows: Blue-superior superficial, green-inferior superficial, and black-posterior. Sectioning reveals a 3.2 x 3.0 x 2.0 cm tumor centrally extending into the upper inner quadrant. The tumor has poorly defined stellate borders and a firm, tan, gritty cut surface. It is located 0.3 cm from the inked posterior margin. The remaining tissue is predominantly fibrous with a few admixed fluid filled cysts. Sections of skin, tumor, and grossly unremarkable fibrous tissue harvested for the Cbcp protocol; matching paraffin sections are as follows: Al: Skin, medial tip. A2: Tumor, lateral portion. A3: Fibrous, 1.0 cm inferior to tumor. A4: Fibrous, 2.0 cm inferior to tumor. A5: Fibrous, 5.0 cm inferior to tumor. Sections through the nipple are placed in cassette labeled A6. There is no surgical scar visible. There is a detached fragment of skin measuring 3.4 x 2.1 x 1.6 cm. A representative section from this tissue fragment is placed in cassette A7. Representative sections of tumor are placed in cassettes A8 through Alo.~Other representative sections are as follows: All: Upper inner quadrant. A12: Lower inner quadrant. A13: Lower outer quadrant. A14: Upper outer quadrant. 14crss. B. RIghr BReAsT received fresh is a 336.0 gram simple mastectomy specimen, 18.0 x 12.5 x 2.5 cm. The specimen is oriented with sutures (long-lateral, short-superior) and inked as follows: Blue-superior superficial, green-inferior superficial, black-posterior. The specimen is serially sectioned revealing predominantly fibrous tissue with scattered admixed cysts measuring up to 1.2 cm in diameter. No disctete masses are identified. One section of each, skin and fibrous tissue (lower outer quadrant) are harvested for the cbcp protocol; mirror images for Histology are in cassettes B1 and B2 respectively. There is no visible scar in the overlying nipple/areola. Sections from the areola are placed in cassette B3. Representative sections from the 1.2 cm cyst from the central superior quadrant (centrally between the upper inner and upper outer quadrant) placed in cassette B4. Representative sections are placed as follows: are Page 2 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 3 ---
+TOR OFFICIAL USE CNLY - PERSCMAL DATA - FRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION (continued) : B5-B6: Upper outer quadrant. B7-B8: Lower outer quadrant. B9-b10: Lower inner quadrant. B11-B12: Upper inner auadrant. 12cFsS 4/27 Page 3 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 End of Report
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diff --git a/output/text/367a621f-7ebb-473c-a8ba-1fd89b428ed6.txt b/output/text/367a621f-7ebb-473c-a8ba-1fd89b428ed6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4fcc6725d0b5d71888e431700cb67772d0feb211
--- /dev/null
+++ b/output/text/367a621f-7ebb-473c-a8ba-1fd89b428ed6.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis This concerns a right hemicolectomy preparation with a tubulovillous adenoma in the cecum, with mild dysplasia of the cylindrical epithelium, with peritumorous, chronic. recidivated concomitant inflammation with acute inflammatory activity. There is a second tubulovillous colon mucus adenoma in the colon ascendens with mild dysplasia of the cylindrical epithelium and reactive concomitant inflammation, with tubular adenomas inn. the area of this second one, with a mucinous carcinoma (corresponding to a mucus-forming adenocarcinoma), with moderate to slight differentiation - corresponding to histopathological differentiation grade 2-3, with tubulovillous adenoma sections on the. surface, with tumor infiltration of the colon wall layers to the tunica muscularis, with. peritumorous chronic recidivated concomitant inflammation, with moderate chronic 1ymphandenitis of the tumor-free local lymph nodes (0/13) and with tumor-free overview slices from all other preparation sections described.. According to the preparation sections at hand, the spreading of the mucinous carcinoma in the colon transversum corresponds to a tumor stage of pT2, pN0, MX, R0. Tumor classification ICDO-DA M-8480/3
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diff --git a/output/text/367c6599-12ee-49d8-af8e-8b8a2ae1768d.txt b/output/text/367c6599-12ee-49d8-af8e-8b8a2ae1768d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..400ebb696853df8aed7ad962dfc22f4094b77f31
--- /dev/null
+++ b/output/text/367c6599-12ee-49d8-af8e-8b8a2ae1768d.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+TSS ID SPECIMENS: JCs-0-3 A. SENTINEL LYMPH NODE #1 LEFT AXILLA B. SENTINEL LYMPH NODE #2 LEFT AXILLA Carcinome, mfilmuHry ductal, nos 8500/3 C. LEFT BREAST MEDIAL NEEDLE LOCALIZATION Sit. srest, nos D. LEFT BREAST LATERAL NEEDLE LOCALIZATION C5s.9 18/ SPECIMEN(S): A. SENTINEL LYMPH NODE #1 LEFT AXILLA B. SENTINEL LYMPH NODE #2 LEFT AXILLA UUID:FE54D4DC-C35E-44D2-B805-08631AE0F89D0 TCGA-E2-A1IK-01A-PR C. LEFT BREAST MEDIAL NEEDLE LOCALIZATION Redacted D. LEFT BREAST LATERAL NEEDLE LOCALIZATION GROSS DESCRIPTION: A. SENTINEL LYMPH NODE #1 LEFT AXILLA Received fresh are 4 tan pink lymph nodes ranging from 0.5cm to 1.5cm in greatest dimensions. Four. touch preps are taken. A1: 1 lymph node A2: 1 lymph node A3: 1 lymph node A4: 1 lymph node B. SENTINEL LYMPH NODE #2 LEFT AXILLA Received fresh are 2 tan pink lymph nodes 0.5cm and 1.2cm in greatest dimensions. Two touch preps. are taken. B1: 1 lymph node B2: 1 lymph node C. LEFT BREAST MEDIAL NEEDLE LOCALIZATION Received fresh labeled with the patient's identification and "left breast medial needle localization" is an oriented 38g, 8 x 5 x 2.2cm needle localized lumpectomy. Ink code: anterior-yellow, posterior-black,. superior-blue, inferior-orange, medial-green, lateral-red. Specimen is serially sectioned from medial to lateral into 6 slices revealing a 1.3 x 1.3 x 1.2cm tan pink well circumscribed firm mass, closest to the posterior margin at 0.1cm and 0.2cm from the anterior margin in slices 3-4. Tissue is procured.. Representatively submitted: C1-C2: medial margin slice 1 C3-C6: slice 2 C7-C10: slice 3 with mass in C9 C11-C15: slice 4 with mass in C13 C16-C19: slice 5 C20-C23: lateral margin slice 6 D. LEFT BREAST LATERAL NEEDLE LOCALIZATION Received fresh labeled with the patient's identification and "left breast lateral needle localization" is an. oriented 11g, 4.5 x 3.5 x 2cm needle localized lumpectomy. Ink code: anterior-yellow, posterior-black, superior-blue, inferior-orange, medial-green, lateral-red. Specimen is serially sectioned from medial to lateral into 6 slices revealing a 0.5 x 0.5 x 0.4cm tan pink well circumscribed firm mass, closest to the inferior margin at 0.5cm in slice 3. Entirely submitted: D1: medial margin slice 1 D2-D3: slice 2 D4-D5: slice 3 with mass in D5 D6-D7: slice 4 D8: slice 5  D9: lateral margin slice 6 DIAGNOSIS: A. SENTINEL LYMPH NODE 1, LEFT AXILLA, BIOPSY: - MICROMETASTATIC CARCINOMA IN ONE OF FOUR LYMPH NODES (1/4) - NO EXTRANODAL EXTENSION IS SEEN. NOTE: Several foci of tumor are seen in one lymph node with the largest measuring 0.5 millimeters. A. cytokeratin AE1/3 stain is positive in tumor cells. B. SENTINEL LYMPH NODE 2, LEFT AXILLA, BIOPSY: - TWO LYMPH NODES, NO TUMOR SEEN (0/2).
+
+--- Page 2 ---
+TSS ID C. breaSt, LEfT, meDiAl, NeeDLe LOCALIZATIOn eXciSIOn: - INVASIVE DUCTAL CARCINOMA, SBR GRADE 2, WITH MUCINOUS FEATURES AND SIGNET RING CELLS. - TUMOR MEASURES 1.4 CM. - TUMOR iS 0.1 CM FROM THE DEEP MARGIN. - SEVERAL FOCI OF ATYPICAL DUCTAL HYPERPLASIA (ADH). D. BREAST, LEfT, LATErAL, NEEDLe LOCALIZATION eXCISION: - INVASIVE DUCTAL CARCINOMA, SBR GRADE 2, WITH MUCINOUSE FEATURES - TUMOR MEASURES 0.7 CM. - mArginS, frRee Of tumOR. - ATYPICAL DUCTAL HYPERPLASIA (ADH). NOTE: The two tumors are morphologically similar. SYNOPTIC REPORT - BREAST Specimen Type: Excision Needle Localization: Yes Laterality: Left Invasive Tumor: Present Multifocality: Yes WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Tumor size: 1.4cm Margins: Negative Tubular Score: 3 Nuclear Grade: 2 Mitotic Score: 1 2 Modified Scarff Bloom Richardson Grade:. Necrosis: Absent Vascular/Lymphatic Invasion:None identified Lobular neoplasia: None Lymph nodes: Sentinel lymph node only Lymph node status: Positive 1 / 6 Micrometastases: Yes  Non-neoplastic areas: ADH, intraductal papilloma with usual ductal hyperplasia DCIS not present ER/PR/HER2 Resuits ER: Positive PR: Positive HER2: Negative by IHC Pathological staging (pTN): pT 1c N 1 mi ClinIcal hIstOry: None provided PRE-OPERATIVE DIAGNOSIS: Left breast carcinoma INTRAOPERATIVE CONSULTATION: TPA1-TPA4: SLN #1 left axilla: 4 lymph nodes- Negative for carcinoma. TPB1-TPB2: SLN #2 left axilla: 2 lymph nodes- Negative for carcinoma. Diagnoses called to Dr. 1 (A, B) by Dr Gross Dictation:, . Microscopic/Diagnostic Dictation: MAn Patholnnict Final Review: , M.D., Pathologist, Final: , M.D., Pathologist
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diff --git a/output/text/369cae10-510b-493d-aded-ddb8f3e5f8dc.txt b/output/text/369cae10-510b-493d-aded-ddb8f3e5f8dc.txt
new file mode 100644
index 0000000000000000000000000000000000000000..95a3bd32e8917ec40fccf3013cb483daff8e55a8
--- /dev/null
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+
+--- Page 1 ---
+TCGA-B9-4617 Diagnosis: idney,left,partial ncphrectomy Histologic tumor type/subtype: renal cell carcinoma, papillary type Histologic yrade (if applicable: Fuhrman grade 2 (of 4) Tumor size (greatest dimension: Extent of tumor invasion: Capsular invasion/perirenal adipose tissue: Minimal perirenal adipose tissue is present and is negative fo carcinoma; tumor invades the renal capsule. Gerota's fascia: Negative for carcinoma Renal vein: Not present Ureter: Not present Venous (large vessel) Negative for carcinoma Lymphatic (small vessel): Negative for carcinoma Histologic assessment.of surgicalmargins:Tumor is 2 mn from black inked renal parenchymal margin Lymph nodes: Not present Other significant findings: Chronic inflammation and mild glomerulosclerosis AJCC Staging: pTla pNx pMx This staging information is based on information available at the time of this report, and is subject to change pending clinical review and additional information. Clinical History: rindry retention. Gross Description: Received is one appropriately labeled container, additionally labeled "Ieft partial nephrectomy.It consists 0f a 14.9 gram,4.5 x 3.5 x2.5 cm partial nephrcctomy. The capsule is inked blue and the parenchyma is inked black. The specimen is serially sectioned to reveal a well demarcated pale tan soft mass measuring 2.4 x2.3 x 2.0 cm. Tumor is given to Tissue Procurement. The mass is entirely submitted in blocks Al-A7.
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diff --git a/output/text/36cb415b-ac48-49e2-aec5-46807433f04e.txt b/output/text/36cb415b-ac48-49e2-aec5-46807433f04e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b5b542bafb967e71fa43719956e1bacf1ed11fc1
--- /dev/null
+++ b/output/text/36cb415b-ac48-49e2-aec5-46807433f04e.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Findings and diagnosis relating to the problem: This is an invasive, mucinous adenocarcinoma of the colon, G3, with penetration of all parietal layers (pT3) and vascular infiltrates (L1, V1) with free resection margins in the mucosa region with a regular mucosa, submucosa and muscularis, as well as mature connective tissue in the deep resection margin area and free lymph nodes, in addition there are tubulovillous adenomas with focally severe dysplasia (high-risk intraepithelial neoplasia) and omental tissue with reactive lesions. Tumor classification: ICDO-DA-M 8140/3 G3 pT3, L1, V1, pN0 (0 of 13).
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diff --git a/output/text/36ccc64e-7715-42b2-a93c-0a0e26bfacdc.txt b/output/text/36ccc64e-7715-42b2-a93c-0a0e26bfacdc.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4122807b4f2e0fc17b18a3ee6bd4f76f3f4c984f
--- /dev/null
+++ b/output/text/36ccc64e-7715-42b2-a93c-0a0e26bfacdc.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+UUID:17B51CA5-E325-4EA0-AFED-C6D0FD5A40EF TCGA-LL-A5YL-01A-PR Redacted PAGE 1 PATIENT : AGE/SX: ROOM : REG DR: REG DOB: BED: DIS: STATUS : TLOC : COLL : TIME IN FORMALIN: 4:16 hrs. CLINICAL INFORMATION:S Pre-Op Diagnosis: Right breast CA Remarks: Specimen(s): A. Right breast tissue stitch axillary tail B, Right axillary node x2 C. #1 sentinel node right breast D. IS level 3 node stitch marks highest lovel node. E. Axillary contents. Ccerc.inoma Lebular nfil tratiug Site CscF  Dreast Nos EO.9 MICROSCOPIC DIAGNOSIS RIGHT BREAST. TOTAL MASTECTOMY: JtJ y/2/l3 A INVASIVE LOBULAR CARCINOMA INVASIVE CARCINOMA MEASURES AT LEAST 4.5 CM IN GREATEST DIMENSION (pT2) NOTTINGHAM COMBINED HISTOLOGIC GRADE 2 OF 3S TUBULE FORMATION SCORE 3 OF 3 NUCLEAR PLEOMORPHISM SCORE 2 OF 3S MITOTIC COUNT SCORE 1 OF 3 SURGICAL MARGINS OF RESECTION FREE OF INVASIVE LOBULAR CARCINOMAS FOCI OF LOBULAR CARCINOMA IN SITUS FOCI OF DUCT CARCINOMA IN SITU. INTERMEDIATE NUCLEAR GRADE, NOT EXTENSIVE SEE COMMENT FOR SURGICAL PATHOLOGY CANCER CASE SUMMARY CHECKLISTS B. RIGHT AXILLARY LYMPH NODES X2. EXCISION: METASTATIC BREAST CARCINOMA IN TWO OF TWO LYMPH NODESS C. SENTINEL LYMPH NODE #1. EXCISION:S NEGATIVE. NO EVIDENCE OF METASTATIC CARCINOMA IN THIS SPECIMENS D. LEVEL 3 AXILLARY LYMPH NODES. REGIONAL RESECTION:S  NEGATIVE. NO EVIDENCE OF METASTATIC CARCINOMA IN SIX HIGHEST LEVEL 3 LYMPH NODES E. RIGHT AXILLARY LYMPH NODES. REGIONAL RESECTION:S METASTATIC BREAST CARCINOMA IN ONE OF 14 AXILLARY LYMPH NODESS COMMENT(S) SURGICAL PATHOLOGY CANCER CASE SUMMARY CHECKLIST - CAP APPROVED Procedure: Total mastectomy ** CONTINUED ON NEXT PAGE **
+
+--- Page 2 ---
+PAGE 2 RUN DATE: RUN TIME: RUN USER: (Continued) PATIENT: SPEC #: COmment(s) (Continued) Sentinel lymph node(s). axillary dissection Lymph Node Sampling: Specimen Laterality: Right Invasive lobular carcinoma Histologic Type of Invasive Carcinoma: Greatest dimension of largost focus of invasion: 45 Tumor Size: mm Glandular/Tubular Differentiation: Score 3 Histologic Grade (Nottingham): Nuclear Pleomorphism: Score 2 Mitotic Rate: Score 1 Overall Grade: Grade 2 DcIs is present: negative for extensive intraductal Ductal Carcinoma In Situ: component (EIC) Architectural Patterns: Cribriform, solid Nuclear Grade: Grade II Necrosis: Present. focal Lobular Carcinoma In Situ: Present Invasive Carcinoma: Margins uninvolved by invasive Margins: carcinoma Distance from closest margin: 10mm DCIs: Margins uninvolved by DCIS Distance from closest margin: >10 mm Number of sentinel lymph nodes examined: 1 : Lymph Nodes: Total number of lymph nodes examined (sentinel and nonsentinel): 23 Number of lymph nodes with macrometastases (>2 mm): Number of lymph nodes with micrometastases (>0.2 mm to 2 mm and/or >200 cells): 0 Number of lymph nodes with isolated tumor cells (.0.2 mm and <200 cells): 0 Number of lymph nodes without tumor cells identified: 20 Extranodal Extension: Not identified Hematoixylin and eosin: level 1 Method of Evaluation: Not identified Lymph-Vascular Invasion: Dermal Lymph-Vascular Invasion: Not identified Primary Tumor: pT2 Pathologic Staging: Regional Lymph Nodes: pN1a Distant Metastasis: Not applicable Ancillary Studies: ER: Positive (92% of tumor cells with nuclear positivity): strong PR: Negative HER2: Positive (score 3+) In Situ Hybridization for HER2: Not amplified ** CONTINUED ON NEXT PAGE ** :
+
+--- Page 3 ---
+RUN DATE RUN TIME: PAGE 3 Specimen Inquiry. RUN USER: SPEC #: PATIENT: (Continued) GROSS DESCRIPTION: The specimen is submitted in five containers A. The first specimen submitted in the fresh state is labeled "right breast tissue". The specimen is the right brsast. total mastectomy specimen. Suture marks the axillary tail of. the breast. There is an ellipsa of white skin containing the nipple. This measures 9 x 4.5 cm. The breast itself measures 23 x 22.5 x 6.5 cm. the surface at approximately the 11 o'clock position. The overlying superficial margin  There is a firm mass palpable beneath adjacent to ths skin is marked with black ink and the deep margin beneath this is marked with blue ink. On cut section the mass measures approximately 4.5 x 3 x 3 cm. The edges are quite difficult to discern and are more easily palpated than visualized.. of the specimen there is a small focus of hemorrhage consistent with previous biopsy. A . In the center portion of this mass is set aside for tissue banking per protocol. The mass extends to within approximately l cm of the overlying superficial margin at approximately 11 o'clock at its closest point. It is located well above the daop margin which is approximately 7 cm beneath the mass. Cut sections through the remainder of the breast tissue reveals some rubbery white parenchymal breast tissue and abundant yellow fat. There are no other. nodules or mass is identified. Sections are submitted as follows:. A1 nipple A2-5 -  mass in breast. A6  mass in breast with adjacent tissue A7-9 -  non-neoplastic appearing breast tissue B. The second specimen is received in the fresh state in the operating room and represents two axillary lymph nodes. one measuring 2 x 1.5 x 1 cm and the other measuring 1 x 0.7 x 0.7 cm. The cut sections are hard. A section of each is examined by frozen section. These are submitted in block B1. frozen section control. Additional section of each is submitted in block B2. C. The third specimen initially in the fresh state is labeled "sentinel node #1" and is a piece of yellow fat measuring 2.5 x 2 x 1 cm with a 1 cm round moderately firm lymph node which is bisected and submitted in toto in block cl. D. The fourth specimen is labeled "level 3 axillary nodes". The specimen is a piece of yellow fatty tissue measuring 9 x 3 x 1.5 cm with a suture marking the highest level 3 lymph node. There are five additional small lymph nodes. block D1 and the other five lymph nodes are submitted in block D2.. The highest node is submitted in E. tissue measuring 10 x 9 x 2.5 cm. Within the fatty tissue are several nodules consistent with lymph nodes.  The largest of these measures 2 cm in diameter and on cut section is. partially replaced by very hard white tissue. A section of each node is submitted in blocks Ei through E4. MICROSCOPIC DESCRIPTION: The slides are examined and evaluated. ** CONTINUED ON NEXT PAGE **
+
+--- Page 4 ---
+PAGE 4 RUN DATE: Specimen Inquiry. RUN TIME: RUN USER (Continued) SPEC #: PATIENT: INTRAOPERATIVE CONSULTATION: OPERATING ROOM CONSULTATIONS : a Portions of the breast mass are processsd for tumor tissue banking per protocol. B. FROZEN SECTION DIAGNOSIS OF RIGHT AXILLARY LYMPH NODES X2: METASTATIC CARCINOMA IN TWO LYMPH NODES PHOTO DOCUMENTATION Image Image Image Image Image Image Signed (signature on file). ** END OF REPORT b 3s13 3[ul3
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diff --git a/output/text/36d147aa-749c-46d8-994e-98c61058994c.txt b/output/text/36d147aa-749c-46d8-994e-98c61058994c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7569e8b4ec7cf9b9fa13ab5e92046a9c5da98b54
--- /dev/null
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+
+--- Page 1 ---
+8-FC2198762 Age/Sex: years/F Redacted Date: Procedure: Left radical mastectomy Preoperative diagnosis: CARCINOMA OF THE LEFT BREAST Postoperative diagnosis: SEE MICROSCOPIC DIAGNOSIS BELOW Specimen(s): 1. LEFT BREAST 2. LEFT AXILLARY CONTENTS Igd-6  3 Corcintms leboulariypltatirg NoS Diagnosis: 85261 3 Site; C YusstNB5 1. LEFT BREAST: C56.9  Infiltrating lobular carcinoma grade 2 yS e/Q1|14  Tumor is 2.8 x 3.5 x 3.0 cm in dimensions  Vascular invasion is not present 2. LEFT AXILLARY LYMPH NODES:  Four (out of fourteen) axillary lymph nodes are positive for metastatic carcinoma. Gross description: 1. LEFT BREAST: Received fresh, is a left breast measured 30.0 x 27.0 x 9.0 cm in dimensions with an axillary fat, en bloc. The firm white-gray tumor 2.8 x 3.5 x 3.0 cm in dimensions is present in the outer quadrants. 2. LEFT AXILLARY CONTENTS: Within the axillary fat there are fourteen lymph nodes ranging from 0.2 to 2.0 cm in greatest dimension.
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diff --git a/output/text/36d4e83f-9351-43e0-b638-39a21dd45a4d.txt b/output/text/36d4e83f-9351-43e0-b638-39a21dd45a4d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..60d42f665581a1037ed5bd5be9d14b8370b9dd5c
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:33569E07-D7BF-491B-A352-CEEA815568000 TCGA-A2-A259-01A-PR Redacted SURGICAL PATHOLOGY REPORT Patient: FMP/SSN: Specimen #: DOb/Age/Sex: ge: IF Race: Location: Taken: Physician(s) : Received: Reported: 1cs-0-3 SPECIMEN: A: SENTINEL LYMPH NODE BIOPSY, LEFT Sarnoma, ifi1tnutng duct; Nos 850f3 B: LEFT BREAST LUMPECTOMY Srte: brast, Nos c50.9 FINAL DIAGNOSIS: A. SENTINEL LYMPH NODE, DESIGNATED LEFT BREAST, BIOPSY: -LYMPH NODES EXAMINED: 2 -LYMPH NODES POSITIVE FOR METASTASIS: 0 (EXAMINATION OF MULTIPLE SECTIONS STAINED WITH HEMATOXIN AND EOSIN AND BY IMMUNOHISTOCHEMISTRY FOR CYTOKERATIN)S B. LEFT BREAST, LUMPECTOMY: -TUMOR TYPE: INVASIVE DUCTAL CARCINOMA -NOTTINGHAM GRADE: 2 (MODERATELY DIFFERENTIATED) -NOTTINGHAM SCORE: 7 (Tubules- 3, Nuclei= 3, Mitoses= 1, mitotic count 4 per 10 HPF at 40x power) -TUMOR SIZE (GREATEST DIMENSION) : GREATEST DIMENSION 1.5 CM (MEASURED GROSSLY) -TUMOR NECROSIS: ABSENT -MICROCALCIFICATIONS: PRESENT IN DUCTAL CARCINOMA IN-SITU, INVASIVE CARCINOMA, AND BENIGN DUCTS -VENOUS/LYMPHATIC INVASION: ABSENT -MARGINS: NOT INVOLVED (BUT CLOSE:) -DISTANCE OF INVASIVE TUMOR FROM NEAREST MARGIN: 0.95 MM FROM SUPERIOR MARGIN (B2) -DISTANCE OF INTRADUCTAL CARCINOMA FROM NEAREST MARGIN: 1.1 MM FROM SUPERIOR MARGIN (B1) -INTRADUCTAL COMPONENT: DUCTAL CARCINOMA IN SITU WITH FOCAL NECROSIS, GRADE 2 COMPRISES LESS THAN 2O% OF THE TUMOR LOBULAR CARCINOMA IN SITU -ESTROGEN RECEPTORS: POSITIVE (REPORTED ON EARLIER CORE BIOPSY -PROGESTERONE RECEPTORS: POSITIVE (REPORTED ON EARLIER CORE BIOPSY -HER 2 NEU by IHC: NEGATIVE (1+) (REPORTED ON EARLIER CORE BIOPSY -PATHOLOGIC STAGE: pT1cNO(i-)MX Page 1 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 Continued on Next Page
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT Patient:. Specimen #: FINAL DIAGNOSIS (continued) : -ADDITIONAL PATHOLOGIC CHANGES: ADENOSIS CHANGES CONSISTENT WITH PRIOR BIOPSY ** Report Electronically Signed Out ** CLINICAL DIAGNOSIS AND HISTORY: left breast cancer GROSS DESCRIPTION: A. Received fresh labeled with the patient's name designated "SENTINEL LYMPH NODE BIOPSY LEFT BREAST" cOnsists of a 4.0 x 3.0  1.0 cm irregular portion of soft tissue. Sectioning reveals two grey yellow fatty lymph nodes each measuring 1.5 x 1.0 x 0.3 cm in overall dimension. The specimen is entirely submitted as follows: A1-A2: lymph node #1 A3-A4: lymph node #2 A5-A6: remaining adipose tissue. 6crns.. B. Received fresh with accompanying radioqraph and embedded localization wire labeled with the patient's name BREAsT LumpecroMy" consists of an irregular portion of tan yellow soft lesignated "LEFT tissue oriented with short stitch superior and long lateral. The specimen. measures 9.5 cm medial to lateral, 6.5 cm superior to inferior, 2.5 cm anterior to posterior. The superior margin is focally disrupted. The specimen is inked as follows: superior blue, inferior green, medial red, lateral yellow, anterior orange, posterior black. Serial sections reveal a fairly well defined pink grey gritty mass measuring 1.5 x 1.2 x 1.0 cm in. overall dimension. The mass comes to within 0.2 cm of the anterior margin and is located 1.0 cm from superior margin. The remainder of the cut surface is composed of markedly dense pink grey fibrous tissue with. lobulated yellow tan adipose tissue. No additional lesions are identified.. Sections are submitted as follows:. B1-B2: mass B3: anterior margin B4: normal appearing fibrous tissue Page 2e Continued on Next Page FOR OFTICIAL USB ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 3 ---
+SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION (continued) : B5-B6: medial and posterior margin B7-b8: superior margin B9-B10: inferior margin B1l-B12: lateral margin. 12crss. Page 3 POR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 End of Report.
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diff --git a/output/text/36f9161a-cf21-404c-939d-c4e350029793.txt b/output/text/36f9161a-cf21-404c-939d-c4e350029793.txt
new file mode 100644
index 0000000000000000000000000000000000000000..830e49d8715393b1d2c555fee1a260bf95cdd205
--- /dev/null
+++ b/output/text/36f9161a-cf21-404c-939d-c4e350029793.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:E72FCA55-8025-4855-9825-039FD1037722 Redacted TCGA-Y8-A8S1-01A-PR ICD-O-3 aeunni, yeanislauy Rersl Research Gross Description Cell 826bJ3 male with renal lesion_ Site: D4jidney NSS Research Dx C64.9 Left lower pole renal mass, partial nephrectomy: Papillary carcinoma, Type 2, cystic. J1/17/14 Small cortical adenoma. CASE SUMMARY FOR NEPHRECTOMY FOR RENAL CELL CARCINOMA: Procedure: Partial nephrectomy Specimen laterality: Left Tumor site: Lower pole of kidney. Tumor size: 2.3 cm Tumor focality: Unifocal Macroscopic extent of tumor: Confined to kidney Histologic type: Papillary carcinoma Type 2 Sarcomatoid features: Absent Tumor necrosis: Absent Histologic grade (Fuhrman Nuclear Grade): 3/4 Microscopic tumor extension: Confined to kidney Margins: Negative (Parenchymal) Lymphovascular invasion: Not identified Pathologic staging (pTNM): Primary tumor: pT1a, 4 cm or less, limited to kidney Regional Iymph nodes: pNX, none sampled Distant metastasis: pMna Pathologic findings in nonneoplastic kidney: Scattered sclerotic glomeruli and interstitial nephritis Other tumors and/or tumor-like lesions: small cortical adenoma AJCC Staging (7th edition) pT1a pNX pMna Research QCJ Tumor T1: 60% tumor nuclei 40% necrosis 0% normal Normal N1: 100% nonneoplastic kidney Research Specimen Specimen Process Time Blood draw time:. Plasma frozen time Serum frozen time Buffy coat frozen time Cold ischemia start time Formalin fixation start time: Total cold ischemia time:
+
+--- Page 2 ---
+Formalin fixation stopped time Total formalin fixation time Specimen Weight Normal 1-115 mg Tumor 1-174 mg Specimen Size Plasma x 3 Serum x 2 Buffy coat x 1 Cryovials x 2 Normal x 1 Tumor x 1 FFPE x2 Normal x 1 Tumor x 1 Study Patient Consent Yes
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diff --git a/output/text/370c715c-9048-46e3-b8eb-a59c38c0b4fd.txt b/output/text/370c715c-9048-46e3-b8eb-a59c38c0b4fd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7d95e8dfc71da1213f2825ff1ab9a0068b7aece2
--- /dev/null
+++ b/output/text/370c715c-9048-46e3-b8eb-a59c38c0b4fd.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:6B180151-FFD6-4261-8B60-80BC3C28E210 TCGA-KV-A74V-01A-PR Redacted Surgical Pathology Report DATE OBTAINED: DATE RECEIVED: DATE REPORTED: CC: DIAGNOSIS #1-excisiOn, fat (perinephric): fat (nO tumor present). #2-ReSectiOn, (Partial), KiDney (right): ReNal PapIlLaRy CarcinOmA - IZD -o -3 Histologic type:  Renal papillary carcinoma, type 2 Sarcomatold features: Carcnomoy nenaspapissoy Not identified Tumor Necrosis Focally present 8240/3 Tumor size: 2.5 cm Fuhrman nuclear grade: NA (ISUP nucleolar grade 2) Sute Judney NOS *Tumor site: Right kidney Tumor focality: C64.9 Unifocal Macroscoplc extent of tumor: Contined to kidney ) 8/QQJ/3 Microscopic extent of tumor: Contined to kidney Lymphatic/vascular invasion: Absent Margins:  Renal parenchymal margin -- negative  Perinephric fat/capsular margin-negative (specimens #1, #2) Non-neoplastlc kidney:  No significant findings Adrenal gland: Not present. Lymph nodes: Not present pTNM: pT1a AJCC STAGE: Stage I (assumes cN0 cM0) ***Electronically Signed Out** COMMENT 88307 Clinical Diagnosis and History: Right renal mass Tissue(s) Submitted: 1: PERINEPHERIC FAT 2: RIGHT RENAL MASS AND SURROUNDING FAT Gross Description: Page 1 of 2
+
+--- Page 2 ---
+Surgical Pathology Report. Specimen #1 is received in formalin labeled perinephric fat and consists of a 5.0 x 5.0 x 1.5 cm aggregate of tan-yellow, soft to Iobulated fibroadipose tissue. The specimen is serially sectioned and no gross lesions are identified. Representative sections are submitted labeled 1A-1B. Specimen #2 is received fresh for intraoperative consultation labeled right renal mass and surrounding fat and consists of a 9 gram, 3.6 x 3.0 x 3.0 cm partial nephrectomy specimen. The parenchymal margin is inked in blue, the capsule is inked in black. The parenchymal margin appears intact and the capsule margin appears smooth, and intact. The specimen is serially sectioned to identify a 2.5 x 2.2 x 1.6 cm tan-pink, focally hemorrhagic mass measuring 0.2 cm from the nearest parenchymal margin and abutting the capsule. The adjacent renal parenchyma is tan-brown, soft. A representative portion of the normal and mass are submitted for TCGA study. Representative sections are submitted labeled as follows: 2A-2F:  tumor to adjacent parenchyma and capsule (2A closest parenchymal margin) 2G: uninvolved parenchyma 2H: surrounding adipose tissue.. Intraoperative Consult Diagnosis 2A/GDX: TUMOR MEASURES ~2MM AWAY FROM THE CLOSEST PARENCHYMAL MARGIN. DISQUALIFIED Page 2 ot 2 END OF REPORT
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diff --git a/output/text/3741a2dd-a4a0-4ec0-903d-167c6494c5a8.txt b/output/text/3741a2dd-a4a0-4ec0-903d-167c6494c5a8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0d5eb1a01fc447dbd9c4d175a6c4e5d9f2b26bbd
--- /dev/null
+++ b/output/text/3741a2dd-a4a0-4ec0-903d-167c6494c5a8.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID: 8C978391-96B4-468D-AAA3-24E196DE03CA Reda cted TCDO- arsinna, inyeltralirig due Age: 8508 Ste. Sex: Female C66.9 Tissue Source Site (TSS): tO 5/i9|14 Date of Tumour Procurement: 1. GROSS ASSESSMENT: Cut section showed a variegated tumour measuring 3.4x2.5x1.5cm 2.MICROSCOPIC ASSESSMENT Microscopic description: Section shows a malignant tumour in cords, solid nests and. tubular patterns. It is composed of large cells having moderately pleomorphic. hyperchromatic nuclei and amphophilic cytoplasm. The stroma is demoplastic containing. similar tumour cells and aggregates of lymphocytes. Focal areas of necrosis noted.. 3. Tumour Type: Malignant 4. Tumour Site: Right Breast 5.Distance of invasive carcinoma to closest margin: -5mm .Which margin? Deep resection.
+
+--- Page 2 ---
+TSS Unique patient ID: 6.  HISTOLOGICAL DIAGNOSIS: Invasive Ductal Carcinoma 7. COMMENTS: Dr Reporting Pathologist Name Signature Date 123
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diff --git a/output/text/37a94ba7-f4d5-443f-93e9-d854ed25092f.txt b/output/text/37a94ba7-f4d5-443f-93e9-d854ed25092f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..671a688b2eb1c083a76f0ea084cb22a045bd7a2b
--- /dev/null
+++ b/output/text/37a94ba7-f4d5-443f-93e9-d854ed25092f.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Patient Name: Accession #: Med.Rec.# Date of Procedure DOB: Date of Receipt: Gender: Date of Report Ref.Physician: Account #: Patient Address: Billing Type: Additional Copy to: Ref.Source Clinical Diagnosis & History History of ocular melanoma right renal mass. Specimens Submitted: 1:Kidney,right renal tumor, partial nephrectomy DIAGNOSIS: Kidney,right renal tumor,partial nephrectomy 7 Tumor Type: Renal cell carcinoma -Papillary type combined type 1 and type 2,high grade Tumor Size: Greatest diameter is 3.2 cm. Local Invasion (for renal cortical types): The tumor invades into the capsule, but not extends through. Renal Vein Invasion Not identified Surgical Margins: Free of tumor The tumor is within 1 mm to the surgical deep margin Non-Neoplastic Kidney Unremarkable Adrenal Gland: Not identified Lymph Nodes Not identified Staging for renal cell carcinoma/oncocytoma: pT1 Tumor <=7.0 cm in greatest dimension limited to the kidney Comment: Immunohistochemical study reveals the tumor cells are positive for CK7,racemase;weakly positive for CD10 and focally positive for 34BE12.The findings support our diagnosis IATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHERMATERIAL).AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Page 1 of2
+
+--- Page 2 ---
+Special Studies: Result Special Stain Comment 34BE12 RACEMASE NEGCONT IMMRECUT CK7 CD10 Gross Description: 1) The specimen is received fresh for frozen section,labeled Right renal tumor' and consists of a partial nephrectomy specimen, measuring 4.2 x 3.3 x 1.5 cm.A stitch marks the deep surface, which is inked, blue, the capsular surface is inked black and the lateral pattern, and margin is inked yellow. The specimen is serially sectioned to reveal a tan white tumor with yellow foci, which measures 3.2 x2 x 1.8 cm.The tumor abuts the capsule and the deep margin. The uninvolved renal parenchyma is grossly unremarkable. Representative sections are submitted after tumor is submitted for Summary of sections: FSC-frozen section control T-tumor R-representative renal parenchyma Summary of Sections: Part 1:Kidney,right renal tumor,partial nephrectomy Block Sect.Site PCs 1 fsc 1 1 r 1 5 t 5 Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS: RENAL CORTICAL NEOPLASM.DEEP MARGIN UNINVOLVED PERMANENT DIAGNOSIS:SAME Page 2of2 END OF REPORT
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diff --git a/output/text/37b4926d-6105-46b5-823d-122c4c65c35f.txt b/output/text/37b4926d-6105-46b5-823d-122c4c65c35f.txt
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index 0000000000000000000000000000000000000000..ac72ed9a23c3bdd69b98540473edef113b7e1b5b
--- /dev/null
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+
+--- Page 1 ---
+Surgical Pathology Report Case #: Name: Collected: DOb: Received: Gender: Reported: MrN: Copy To: Location: Physiclan: Pathologic Interpretation: A BREAST, EXCISIONALANCISIONAL BIOPSY: - 1NVASIVE MAMMARY CARC!NOMA, poorly differentiated, Nottingham grade 3 (3+3+2=8), 2.0 cm in greatest dimension. - Margins are free of tumor. - Tumor cells are reported to be negative for ER, PR and Her2 by immunohistochemistry performed on patent's previous biopsy - See tumor summary. 1cs-0-3 8500/3 Cavcinoms7 m fttruHng cluct,nos FS: B. SENTINEL NODE #1 C50.9 3/1/ St: bresot Nos - No carcinoma seen in one lymph node (0/1). - Keratin immunostain is pending. SENTINEL NODE #2: . Fs: c. - Metastatic carcinoma in one lymph node (1/1). UUID:2E77693B-FAAD-4CCC-BD4F-3D2470C25143 - Largest metastatic deposit, 2.5 cm. TCGA-EW-A1PH-01A-PR Redacted - Perinodal extension is not identified. SENTINEL NODE #3 , FS: D. - No carcinoma soen in one lymph node (0/1). - Keratin immunostain is pending. E. Axillary Content Right SIDe: - No carcinoma seen in seven lymph nodes (0/7). Tymor Symmary Specimen: - Partial breast Procedure: - Excision without wire-guided localization Lymph Node Sampling: - Sentinel lymph node(s) - Axillary dissection (partial or complete dissection) Specimen Integrity: - Muttiple designated specimen (eg, main excision and identified margins). Speclmen Size:d - Greatest dimension: 7 cm * Additional dimension: 6 x 4 cm. Laterality: - Right Tumor Size: Size of Largest Invasive Carcinoma - Greatest dimension of largest focus of invasion over 0.1 cm: 2 cm. * Additional dimensions: 2 x 1.6 cm Tumor Focality: - Single focus of invasive carcinoma Macroscopic and Microscopic Extent of tumor: - Skin: Skin is not present - Skeletai muscle: No skeletal muscle present Ductal Carclnoma In (DCIS): No DCIS is present Lobular Carcinoma IN Situ (LCIS): Not identified. Histologic Type of Invasive Carcinoma: - Invasive carcinoma Histologic Grade: Nottingham Histologic Score Glandular (Acinar)/Tubular Differentiation: Score 3 Nuclear Pleomorphism: Score 3
+
+--- Page 2 ---
+SURGICAL PATHOL Report Mitotic Count: Score 2 Overall Grade: Grade 3: score of 8 Margins: - Margins uninvolved by.invasive carcinoma. - Distance from closest margin: 1 mm (anterior, posterior, lateral) *Specify margins: Distance from superior margin: 3 mm Distance from inferior margin: 2.5 mm Distance from anterior margin: 1 mm Distance from posterior margin: 1 mm Distance from medial margin: 2 mm Distance from lateral margin: 1 mm Treatment Etfect: Response to Presurgical (Neoadjuvant) therapy: - In the Breast: No definite response to presurgical therapy in the invasive carcinoma - In the Lymph Nodes: No definite response to presurgical therapy in metastatic carcinoma Lymph-Vascular Invasion: Not identified.. Dermal Lyrmph-Vascular Invaslon: No skin presentd Lymph Nodes: - Number of sentinel lymnh node. axamined: 3 - Total numbe : examined (sentinel and Nonsentinel): 10. - Number of ' .n macrometastases (>0.2 cm): 1 *Extrano: identlfied *Ma..- antir -- . vmph Nodes: Hematoxylin and eosin (H&E), one leve!  .aging: umor: pT1c ylonal Lymph Nodes: pN Distant Metastasis: Not a, .... Ancillary Studies: Estrogen Racaptor: - Performed on arcther sr*cimen: Results: No immunoreactive tumor cells present ^reatarone : Results:No immunoreactive tumor cells present.. Her. - Performed on a. ou idr specumer. 1: Results: Nogative (Score 0) Prellminary AJCC Ciassificatlon (7t Edition) pT1c pN1a Mn/ad (Final AJCC c'?*: -tion pending evaluatlon of keratin staln on sentinel nodes) NO:: " immunohistochemical an) 1DScn.gR 636=PR.A43=HER2.H tOFR.A. Hnonurochemical siains are wsed with formalin or molecular fixed. parefhin embeddrd tissue. Derction is by Envision Meuhod. Thd resuis are reod by a pathoiogist us positive or negative. As the attending pathologist, I attest that I: (i) Examined the relevant preparation(s) for the specimen(s): and (ii) Rendered the diagnosis(es).. ***Electronically Signed Out By*** Procedures/Addenda Addondum Date Ordered: Status:  Signed Out Date Complete: Date Reported: Addendum Diagnosis B. SENTINEL NODE #1 t FS: - Immunohistochemistry for keratin is negative for carcinoma. Page 2 of 4
+
+--- Page 3 ---
+SURGICAL PATHOL Report SENTINEL NODE #3 ). FS: D. - Immunohistochemistry for keratin is negative for carcinoma. Intraoperative Consultation FS:  No carcinoma seen B. Sentinel node #1  C.Sentinel node #2 FS:Metastatic carcinoma to one lymph node Sentinel node #3 , FS:  No carcinoma seen D. MD MD Clinical History: None Provided Qperation Performed Right breast lumpectomy with sentinel node biopsy and possible node dissection Pro Qperative Diagnosis: Breast cancer Specimen(s) Received: A: Breast, excisionalincisiona! biopsy B: Sentinel node #1 1, FS C: Sentinel node #2 ( ,FS D: Sentinel node #3 1 l, FS E: Axillary content right side Gross Description; A. Received in formalin is a 43 gram, 7.0 x 6.0 x 4.0 cm lumpectomy specimen, oriented with one stitch superor, two stitches lateral and three stitches deep. Resection margins are inked as follows: Superior blue, inferior green, medial red, lateral orange, anterior yellow, posterior black. On serial sections through the specimen, there is a tan-white indurated mass with ill-defined borders, measuring 2.0 x 2.0 x 1.6 cm. This lesion is situated less than 1 mm from the anterior resection margin, 1 mm from the lateral resection margin, 7 mm from the mediai margin, 4 mm from the deep margin,and 20 cm. Sections submitted as from superior margin and 2.5 cm from the interior margin. No other lesions are identified. follows: 1 Leslon in relation to anteror and posterior margin 2 Latera! margin 3 inferior and medial margin 4 Superior margin 5-8 Lesion submitted in toto 9&10 Additional sections of the specimen with fibrotic area 8. Received fresh is a segment of tan-grey soft tissue, measuring 1.0 x 1.0 x 0.4 cm. Bisected and submittedin toto in ane cassette for frozen. c. Received fresh is a segment of tan-brown soft tissue, measuring 0.7 x 0.3 x 0.2 cm. Submitted in toto in ore cassette for frozen. D. Received fresh is a segment of tan-grey soft tissue, measuring 1.5 x 0.7 x 0.4 cm. Submitted in toto in onelcassette for frozen. Page 3 of 4
+
+--- Page 4 ---
+SURGICAL PATHOL Report E.  Received in formalin is a tan-yellow fibroadipose tissue, measuring 11.0 x 6.0 x 2.0 cm.  Examination of the specimen reveals multiple possible lymph nodes.Sections submitted as follows: 1-3 One lymph node bisected per cassette 4&5 Two lymph nodes in toto per cassette MD( 312/ Page 4 of 4
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diff --git a/output/text/37b5da06-fd66-4412-80a2-3638b24b2d27.txt b/output/text/37b5da06-fd66-4412-80a2-3638b24b2d27.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b15ac61f656a70cb2adf6fb6b76c215058fa4368
--- /dev/null
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+
+--- Page 1 ---
+ICD-O-3 UUID:4AA9CDF4-596B-4F79-A94A-ED618A789120 TCGA-2Z-A9JG-01A-PR Redacted ceQl 826Ol3 Site D$3:sney NsS C649 Pathology Report CtO 4/Q8J14 Final Diagnosis. A. LEFT KIDNEY, PARTIAL NEPHRECTOMY: Renal cell carcinoma, papillary type 2, Fuhrman nuclear grade 3 of 4. See Key Pathological Findings. B. DEEP MARGIN, PARTIAL NEPHRECTOMY:  Renal parenchyma, negative for carcinoma. I. the attending pathologist, personally reviewed all $lides and / or materials and rendered the final diagnosis. Electronically Signed Out by Key Pathological Findings Tumor type: Renal cell carcinoma, papillary type 2. Nuclear grade: Fuhrman nuclear grade 3 of 4. Pattern of growth: Papillary. Tumor size: 2.8 cm. Invasion through Renal capsule: Not identified.. Invasion of Gerota's Fascia Not applicable. Renal vein invasion:. Not applicable. Surgical margins. Free. Non-neoplastic kidney: Focal mild chronic inflammation. Adrenal gland: Not applicable. Lymph nodes. Not applicable. Pathdlogic stage: pT1aNXMX. Specimen(s) Received A LEFT PARTIAL NEPHRECTOMY FS B DEEP MARGIN LEFT PARTIAL NEPHRECTOMY FS Clinical History Left renal mass. Preoperative Diagnosis Left renal mass. Intraoperative Consultation. FSA1: LEFT PARTIAL NEPHRECTOMY: Papillary carcinoma. Parenchymal margin negative FSB1: DEEP MARGIN LEFT PARTIAL NEPHRECTOMY: Benign renal tissue. No evidence of malignancy.. Comment: These frozen section diagnoses/results were communicated to and acknowledged by Dr.
+
+--- Page 2 ---
+ have performed the intraoperative consultations and issued the above diagnoses. Gross Description A. Specimen A is received fresh for frozen section, labeled "lefl partial nephrectomy, ink is. margin" and consists of a partial nephrectomy (3 x 3 x 1 cm) with a moderate amount of perinephric adipose tissue attached. The specimen measures in overall dimension,4.5 x 5 x 2 cm. The specimen is oriented according to the surgeon's designation and is inked as follows: Parenchyma resection margin is inked blue and perinephric adipose tissue resection margin is inked green. The specimen is serially sectioned to reveal an irregular to roughly ovoid,partially solid and partially cystic tumor which measures 2.8 x 2.5 x 0.8 cm. The tumor is bulging capsule and extends to within 0.1 cm of the closest parenchymal margin. Representative section of the specimen with tumor in relation to. the closest margin is submitted for frozen section as FSA1. Representative section of the specimen is submitted to the Tissue Procurement Laboratory. The remainder of the partial nephrectomy is submitted entirely in 7 cassettes A2-A8. B.  Specimen B is received fresh tor frozen section, labeled *deep margin left partial nephrectomy.ink is margin and consists of an irregular fragment ot tan-red-brown,rubbery tissue measuring 1.5 x 0.2 x 0.2 cm.The specimen is oriented according to the surgeon's designation and the true margin is re-inked blue. No tissue is submitted to the Tissue Procurement Laboratory. The specimen is submitted entirely for frozen section as FsB1. 13/14
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diff --git a/output/text/37d99d59-b6bb-4f2a-8e46-cba283b2da52.txt b/output/text/37d99d59-b6bb-4f2a-8e46-cba283b2da52.txt
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index 0000000000000000000000000000000000000000..55525075f3d1b2c8455db9c6adec9b164b15c6d1
--- /dev/null
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+
+--- Page 1 ---
+UUID:B7EB0E0B-46C5-43C0-A78D-FB094290765A TCGA-WT-AB44-01A-PR Redacted SURGICAL PATHOLOGY REPORT NAME: SURG PATH #: MR #: SPECIMEN CLASS: BILLING #: ALT ID #: LOCATION: DATE OF PROCEDURE: AGE: SEX: DATE RECEIVED: DOB: TIME RECEIVED PHYSICIAN: DATE OF REPORT: COPY TO: DATE OF PRINTING: TOD-c3 rsuntna ttnfiltatimyQsboular n0s 35Qcf3 Material Received: A: left breast SLN #1 time out OY3ua#Nos c 5o.9 B: left breast SLN #2 time out C: left breast SLN #3 time out D: left breast SLN #4 time out E: left breast lumpectomy time out C @60,4) F: additional anterior left breast tissue  5/30/y History:  year-old female with history of invasive lobular carcinoma of the breast. Final Diaanosis: A.Lymph node (1), "left breast SLN #1", biopsy:. There is no evidence of malignancy in one lymph node.(0/1) Deeper sections and a pancytokeratin immunostain are negative in support of the above diagnosis. B.Lymph node (1), "left breast SLN #2", biopsy:. There is no evidence of malignancy in one lymph node. (0/1). Deeper sections and a pancytokeratin immunostain are negative in support of the above diagnosis. C. Lymph node (1), "left breast SLN #3", biopsy: There is no evidence of malignancy in one lymph node. (0/1) Deeper sections and a pancytokeratin immunostain are negative in support of the above diagnosis. D. Lymph node (1), "left breast SLN #4", biopsy: There is no evidence of malignancy in one lymph node. (0/1) Deeper sections and a pancytokeratin immunostain are negative in support of the above diagnosis. E.Breast, "left breast lumpectomy", lIumpectomy:. Invasive lobular carcinoma, moderately differentiated.  See comment. Lobular carcinoma in-situ and atypical lobular hyperplasia Previous biopsy site changes. F. Breast, "additional anterior left breast tissue", excision:. Microscopic focus of invasive lobular carcinoma.  See comment. Lobular carcinoma in-situ and atypical lobular hyperplasia. MR #: Page 1 of 4 Date of Printing: SURGICAL PATHOLOGY REPORT Order Number:
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT  NAME: SURG PATH #: MR #: ALT ID #: Comment: INVASIVE CARCINOMA OF THE BREAST Specimen Type: Lumpectomy Laterality: Left Tumor Site: 1:00, 6 cm FTN Histologic Type: Invasive lobular carcinoma Size of Invasive Component: 1.5 cm in greatest dimension in the main lumpectomy. 0.3 cm in greatest dimension in the separately submitted "additional anterior left breast tissue". Tumor Multicentricity: Yes Surgical Margins:  The carcinoma is focally 1.5 mm from the anterior margin and focally 1.75 mm from the inferior margin in the main lumpectomy (Specimen E); ail other margins are greater than 0.2 cm away. In specimen F ("additional anterior left breast tissue") which is unoriented, carcinoma is present at one shave margin/tissue edge while all other margins are 0.2 cm or greater away Histologic Grade (Nottingham Histologic Score): II/II Tubule Formation: 3 Nuclear Grade:  2 Mitotic Count (40x objective): 1 Total Nottingham Score: 6/9 Ductal Carcinoma In-situ (DCiS): Absent Lobular Carcinoma In-situ (LCIS): Present Lymph-Vascular Invasion:  Not identified Perineural Invasion:  Not identified. Tumor Necrosis: Absent Nipple Involvement:  Not applicable Skin Involvement:Not applicable. Lymph Node Sampling:. Sentinel lymph node(s) only Total number of involved nodes/total nodes found: 0/4 Non-neoplastic Breast Tissue: Focal atypical ductal hyperplasia. Fibrosis and prior biopsy site changes. Prognostic markers: Ordered on prior biopsy. See for addendum Time between tumor removal and placement into formalin  1 hour: Yes Fixation Time between 6-48 hours:  Yes Pathologic Staging: pT1c snN0(i-) Primary Tumor (Invasive Carcinoma) (pT) pT1c: Tumor >10 mm but d20 mm in greatest dimension Regional Lymph Nodes (pN) Modifier (required only if applicable) (sn): Only sentinel node(s) evaluated. If 6 or more sentinel nodes and/or nonsentinel nodes are removed, this modifier should not be used. pNO (i-): No regional lymph node metastases histologically, negative IHC Distant Metastasis (M) Not applicable The pathologic stage assigned here should be regarded as provisional, as it reflects only current pathologic data and does not  incorporate full knowledge of the patient's clinical status and/or prior pathology. In Specimen F, immunohistochemical stain for smooth muscle myosin supports the diagnosis. Attestation: By this signature, I attest that I have personally formulated the final interpretation expressed in this report and that the above diagnosis is based upon my examination of the slides and/or other material indicated in this report ***Electronically Signed Out By*** Interpreted by: MR #: Page 2 of 4 Date of Printing:. SURGICAL PATHOLOGY REPORT
+
+--- Page 3 ---
+SURGICAL PATHOLOGY REPORT NAME: SURG PATH #: MR #: ALT ID #: Resident Gross Description: A.  Received in formalin labeled with the patient's name "left female breast sentinel lymph node #1 out at  are two tan-pink lymph nodes measuring 0.9 x 0.9 x 0.6 cm and 1.4 x 1.3 x 0.6 cm. The smaller lymph node is inked black. Both lymph nodes are. serially sectioned and submitted entirely in cassette A1. B. Received in formalin labeled with the patient's name "female left breast sentinel lymph node #2 time out " is a 2.3 x 1.8 x 0.6 cm aggregate of yellow-tan fibroadipose tissue that is palpated to reveal two possible lymph nodes measuring 1.2 x 0.8 x 0.4 cm and 1.5 x 0.7 x 0.5 cm. The smaller lymph node is inked black.  Both lymph nodes are serially sectioned and submitted. entirely in cassette B1. C. Received in formalin labeled with the patient's name and "female left breast sentinel lymph node #3 time out. " is a 3.2 x 1.7 x 0.9 cm aggregate of yellow-tan fibroadipose tissue that is palpated to reveal two possible lymph nodes measuring 0.5x 0.5 x 0.3 cm and 1.0 x 0.6 x 0.4 cm. The smaller lymph node is inked black. Both lymph nodes are serially sectioned and submitted. entirely in cassette C1. D.  Received in formalin labeled with the patient's name and "left female breast sentinel lymph node #4 out at ." is a 2.2 x 1.1 x 0.8 cm aggregate of yellow-tan fibroadipose tissue that is palpated to reveal one possible lymph node measuring 0.4 x 0.3 x 0.3. cm. The specimen is serially sectioned and submitted entirely in cassette D1. Received fresh labeled with the patient's information and "female left breast lumpectomy' is a 35 gm lumpectomy specimen measuring 7.0 x 5.5 x 1.0 cm. The specimen has already been inked by the surgeon as follows:. Orange -- Lateral Yellow-Medial Red -- Superior Blue - Inferior Green -- Anterior Black -- Posterior. The specimen is serially sectioned from lateral to medial into twelve slices. In slices 6 through 8, there is a 1.2 x 0.7 x 0.6 cm firm. white well circumscribed mass that is: 0.1 cm from the anterior margin. 1.8 cm from the posterior margin 1.5 cm from the superior margin. 2.2 cm from the inferior margin. 2.0 cm from the lateral margin. 1.6 cm from the medial margin. The remainder of the breast parenchyma is yellow-white adipose tissue. The specimen is entirely submitted as follows: E1 Slice #1 (lateral margin). E2 Slice #2. E3-4 Slice #3 bisected. E5-7 Slice #4 trisected. E8-9 Slice #5 bisected. E10-12 Slice #6 trisected. E13-14 Slice #7 bisected. E15-17 Slice #8 trisected. E18-20 Slice #9 trisected. E21-22 Slice #10 bisected E23-24 Slice #11 bisected. E25 Slice #12 (medial margin). The specimen was removed from the patient at and placed in formalin at on and not removed from formalin until  Received in formalin labeled with the patient's name and *additional anterior left breast tissue" is a 2.7 x 1.9 x 1.0 cm piece of yellow lobular adipose tissue. The outer surface is inked black. The specimen is serially sectioned to reveal a yellow homogeneous cut surface with no discrete lesion or abnormalities identified. The specimen is entirely submitted in cassettes. MR #: Page 3 of 4 Date of Printing: SURGICAL PATHOLOGY REPORT
+
+--- Page 4 ---
+SURGICAL PATHOLOGY REPORT NAME: SURG PATH #: MR #: ALT ID #: F1-F3.The breast was removed from the patient at , and placed in formalin immediately in the OR and not removed from formalin until On today's date.  If immunohistochemical stains and/or in situ hybridization are cited in this report, the performance characteristics were determined by the. in compliance with CLiA'88 regulations. Some of these tests rely on the use of "analyte specific reagents" and are subject to specific labeling requirements by the FDA. Known  positive and negative control tissues demonstrate appropriate staining.This testing was developed by the. It has not been cleared or approved by the FDA. The FDA has determined that such clearance or approval is not necessary. MR #: Page 4 of 4 SURGICAL PATHOLOGY REPORT Date of Printing:
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new file mode 100644
index 0000000000000000000000000000000000000000..dad1b1bfbe201778eb602980ef86e3418724c0fc
--- /dev/null
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+
+--- Page 1 ---
+*** Diagnosis / Diagnoses: *** Right hemicolectomy specimen with tumor-free resection margins and under inclusion of an ulcerated, moderately differentiated adenocarcinoma of the ascending colon, exhibiting lymphatic vessel invasion, with infiltration of the perimuscular fatty tissue, and without regional lymph node metastases (G2, pT3 pN0 0/18 L1 V0 R0)
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diff --git a/output/text/384fe6fb-18ca-4530-b0aa-2113a6b89e1f.txt b/output/text/384fe6fb-18ca-4530-b0aa-2113a6b89e1f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..27c528797cb55b160e2e992606efa57d681aa907
--- /dev/null
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+
+--- Page 1 ---
+*** Diagnosis / Diagnoses: *** Resectate of portion of colon (sigmoid colon) with an ulcerated colon carcinoma conforming to the histological type of a moderately differentiated colorectal adenocarcinoma, extending no closer than 6 cm to the resection margin and with a greatest diameter of 3 cm. Invasive spread of tumor within all layers of the intestinal wall and as far as the neighboring mesocolic fatty tissue.. Remainder of the intestinal mucosal membrane with a small, tubular adenoma with mild epithelial dysplasia (synonym: low-grade intra-epithelial neoplasia). Oral and aboral resection margins tumor-free.. Twenty-two mesocolic lymph nodes with uncharacteristic reactive changes and tumor- free. Tumor stage thus pT3 pN0 (0/22) L0 V0; G2
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diff --git a/output/text/38852d99-9cf5-4ef3-bcea-b4def27e51ea.txt b/output/text/38852d99-9cf5-4ef3-bcea-b4def27e51ea.txt
new file mode 100644
index 0000000000000000000000000000000000000000..73680a4dd9e7b81692e3d5d589c742a99a500094
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TCGA #: Sample ID  Diagnosis: Resected section of colon (rectosigmoid) with an ulcerated colon carcinoma characterized histologically as a poorly differentiated, partially mucinous adenocarcinoma of the. colorectal type, extending a max of 10 cm to a resection margin, and measuring a. maximum of 2.5 cm in diameter at the widest point. Invasive spread of the tumor within all intestinal wall layers to the neighboring mesocolic fatty tissue. Numerous lymphatic processes in the region of the tumor margin. The remaining intestinal wall has no relevant. pathological findings; in particular, no evidence of pseudodiverticula. Tumor-free oral and aboral resection margin.. 12 local lymph nodes with metastases of the rectal carcinoma partly transgressing the. lymph node capsules. Stage of tumor: pT3, pN2 (12/12) L1 V0; G3 R0 1CO-0-3 Adinocaicliomo mncin ous, no5 848o/3 SiKe; Nntosigmoid,co1n C19.q pw 3/3r/u UUID:B52F7D2A-2177-4A2A-A941-042D661D3F37 TCGA-AA-A01D-01A-PR
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diff --git a/output/text/388f7642-06cc-4903-9b22-186623399513.txt b/output/text/388f7642-06cc-4903-9b22-186623399513.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8d9ddb7a51dafeb2941b7e72fe827ca01642e60a
--- /dev/null
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+
+--- Page 1 ---
+ICD-3 UUID: E0AA1F55-51DD-4D22-81E5-E3473A195864 TCGA-UW-A7GR-01Z-PR Redacted Cersnomo, renal cQl. CUonsp/slu tyype 83i7|3 C64.9 Surgical Pathology Report n 9/24|L3 Diagnosis: A: Right kidney, nephrectomy - Renal cell carcinoma, chromophobe type, nuclear grade 2 (of 4), tumor size 6.0 cm in greatest dimension, tumor confined to kidney, surgical margins free of tumor - Tiny renomedullary interstitial cell tumor, 2 mm, in medullary pyramid - Portions of renal artery, vein and ureter with no tumor seen B: Hilar lymph node, removal - No tumor seen in one lymph node (0/1) Clinical History: The patient is a year-old with a right renal mass. Gross Description: Received are two appropriately labeled containers. Container A: Specimen fixation: formalin Type of specimen: laparoscopic nephrectomy Side of specimen: right. Size and weight of specimen: 450 grams, 15.5 x 9.0 x 7.0 cm Presence/absence of adrenal gland: absent Tumor description/site: circumscribed, tan/orange with focal hemorrhage and present in the lower pole Tumor size: 6.0 x 5.0 x 4.5 cm Presence/absence of multicentricity: absent Confinement/non-confinement to the kidney: confined to the lower pole but expanding the capsule Extent of invasion: Perirenal adipose tissue: tumor grossly does not involve Gerota' s fascia: tumor grossly does not involve Renal vein: tumor grossly does not involve Ureter: tumor grossly does not involve Other organs: tumor grossly does not involve Surgical margins: Perirenal adipose tissue: negative, less than 0.1 cm from the anterior surface
+
+--- Page 2 ---
+Renal vein: negative Renal artery: negative. Ureter: negative Description of kidney away from tumor: grossly unremarkable; no cysts or nodules present Lymph nodes (hilar): none identified Other significant findings: none Tissue submitted for special investigations: none Block summary:. A1 - ureter, vascular, tangential margins of resection A2,A3 - tumor expanding renal capsule A4 - tumor and overlying pelvic urothelium A5 - tumor and adjacent renal parenchyma. A6 - tumor and anterior margin closest approach A7 - sample from hilar fat A8 - representative of upper pole, normal appearing kidney A9 - 0.5 cm solid white nodule located in the central renal parenchyma Container B is additionally labeled "hilar lymph node." It consists of a 2.9 x 2.4 x 0.6 cm aggregate of fibrofatty tissue containing a solitary 1.7 x 1.2 x 0.6 cm lymph node candidate. The lymph node is sectioned and entirely submitted in block B1. The remainder of the fat is submitted as block B2. Light Microscopy: Light microscopic examination is performed by Dr. Histologic tumor type/subtype: renal cell carcinoma, chromophobe type Histologic grade (if applicable): grade 2 (of 4) Tumor size (greatest dimension): 6.0 cm. Extent of tumor invasion:. Capsular invasion/perirenal adipose tissue: absent Gerota' s fascia: absent. Renal vein: absent Ureter: absent Venous (large vessel): absent Lymphatic (small vessel): absent Histologic assessment of surgical margins:. Perirenal adipose tissue: free of tumor Gerota' s fascia: free of tumor
+
+--- Page 3 ---
+Renal vein: free of tumor  Renal artery: free of tumor Ureter: free of tumor Adrenal gland: absent Lymph nodes: no tumor seen in one lymph node (0/1). Other significant findings: a tiny renomedullary interstitial cell tumor, 2 mm (Notation added This is a non-malignant tumor, M8966/0). DQ.PRirtveatment Iw 8/31r 30ft3
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diff --git a/output/text/38b58f11-8a84-4b72-a389-ea1a0a17080f.txt b/output/text/38b58f11-8a84-4b72-a389-ea1a0a17080f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3ff3c6accc50be0fdc4df941c389d629afe217c9
--- /dev/null
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+
+--- Page 1 ---
+JCD-0 -_3 Carcnoma, dluctal N0s 85oof3 Psth Site: BrsstLFQ C50.3 19/1 CqcF SiFe: bruotj N0s c5o.9 Diagnosis: 1. Poorly differentiated ductal breast carcinoma (maximum dianeter 4.5 cm, malignancy grade IIl) with widespread tumor infiltration of the skin also with ulceration of the skin, along. with invasion of the lymph vessels and infiltration of the neural sheaths. Remainder of glandular body fibrolipomatous and in advanced involution, also with cystic duct ectasia. No calcification. No evidence of DCIS. At the site of the nodular formation already macroscopically documented in the region of the cranial resection line (skin) cutaneous/subcutaneous tumor infiltrates, also with invasion of the lymph vessels here. Other safety margins free of atypia. Tumor classification: pT4b pN2 (at least, see conglomerate tumors), MX, R1 (see cranial resection line, axillary soft tissue!), G3 (L1, V0).. UUID: 46C0AB78-82FC-4D06-9F26-22AEC8BEEDA7 TCGA-A8-A09Q-01A-PR Redacted
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diff --git a/output/text/38c4c8cb-97b3-45c4-b2ca-6d4292b4a1cb.txt b/output/text/38c4c8cb-97b3-45c4-b2ca-6d4292b4a1cb.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4545fe1e27b612e28f8c887273473f599c253551
--- /dev/null
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+
+--- Page 1 ---
+JcD-0-3 Cercinoma, mnfitrat'rg ductal, Nos 85os/3 SAer Bruat, Nos c50.9 y19fu p Diagnosis: Invasive ductal breast carcinoma (malignancy grade Il) with angioinvasion and penetration of the retromamillary fibromuscular tissue. But no actual infiltration of the skin. Penetration also as far as the fascia. However, dye-stained resection margins are free of atypia. In the tumor nucleus and the remaining glandular body are multicentric manifestations of an intraductal breast carcinoma (grade II). No coarse calcifications. Fibrocystic base structure. Separately examined resection margins free of atypia. Tumor classification: pT2 (max. diameter 3.8 cm), pN3a (12/17), pM1, R0; G2 (L1, V0); EIC. UUID: 2F102533-4B6B-4411-9080-3697ED3099EA TCGA-A8-A080-01A-PR Redacted
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diff --git a/output/text/38d4396b-847d-4ae7-80a8-6831e6ed734a.txt b/output/text/38d4396b-847d-4ae7-80a8-6831e6ed734a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b78f76d3fc9932ab077602137ab86fe4286f9009
--- /dev/null
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+
+--- Page 1 ---
+TCGA-A6-2679 SPECIMEN A. Left tube and ovary. B. Uterus, cervix, right tube and ovary C. Right colon FROZEN SECTION DIAGNOSIS A. Ovarian serous cyst adenofibroma.. GROSS DESCRIPTION A. Received fresh for frozen section, labeled "left tube. and ovary" is a 658 gram, 12.0 x 10.0 x 8.7 cm. attenuated. white pink-red cystic structure, with an attached, fimbriated, 10.5. cm. fallopian tube averaging 0.25 cm. in diameter. The fallopian tube lumen is pinpoint and stellate on sectioning. On opening the. ranges from smooth white pink to wrinkled tan white-gold. No. papillations are evident. A frozen section is performed (see frozen section diagnosis)..  No definitive residual ovarian stroma is identified grossly.. Representative sections are submitted in six additional blocks. B. Received in formalin, labeled "uterus, cervix, right tube with ovary" is a 22 gram, 2.8 cm. (superior to inferior) x 2.5 cm.(cornu to cornu) x 1.5 cm.(anterior to. posterior) symmetrical uterine corpus with attached 1.5 cm. cervix and right adnexa. The serosa is smooth, tan pink-red. The 2.3 x 1.9 cm. mottled white pink-red ectocervix surrounds a 0.2 x 0.1 cm. os. The. cervical mucosa is moderately trabecular, tan pink with a 0.6 x 0.2 x 0.2 cm. soft white pink endocervical polyp anteriorly (see block. 1). The triangular, 1.8 x 1.0 cm. uterine cavity is lined by flat. white pink endometrium averaging 0.15 cm. The myometrium is smooth, pale tan-pink and averages 1.0 cm. in thickness. No intramural leiomyomata are present. The cribriform tan pink-gold right ovary. measures 1.3 x 0.8 x 0.5 cm. The stroma is pale tan with GROSS DESCRIPTION identifiable corpora albicantia. In addition, there is a single, 0.4 cm. smooth lined serous fluid-filled cyst. The fimbriated tan. pink right fallopian tube measures 4.3 cm. in length and averages 0.3 cm. in diameter with a pinpoint stellate lumen on sectioning. Representative sections are submitted in five blocks as labeled. RS-5. BLock suMMARy: 1 - anterior cervix; 2 - posterior cervix; 3 - anterior endomyometrium; 4 - posterior endomyometrium; 5 - right tube and ovary.
+
+--- Page 2 ---
+C.  Received fresh labeled "right colon" is a previously. unopened 30 cm. segment of proximal right colon with. attached 11.5 cm. of distal ileum surfaced by smooth to scabrous tan pink serosa with a moderate amount of attached mesentery and mesocolon. An unremarkable, 4.5 cm. appendix averaging 0.6 cm. in. diameter is present. The proximal and distal margins measure 3.7 and 5.7 cm. in circumference respectively. On opening there is a well circumscribed, 2.8 x 2.0 rubbery white-pink-red sessile ulcerated lesion located 20 cm. from the distal margin. A portion of the tumor and a portion of normal mucosa are submitted for tissue procurement as requested. On sectioning the tumor has a maximal thickness of 0.7 cm., grossly extending into the muscularis to. within 0.6 cm. of the inked free radial serosal surface. The ileal mucosa and uninvolved colonic mucosa are unremarkable glistening tan pink with regular folds and the walls average 0.5 cm. in thickness. Several soft to slightly rubbery tan pink tissues in keeping with lymph nodes measuring up to 0.9 cm. in greatest dimension are recovered from the attached mesocolon and mesentery. Representative sections are submitted in 13 blocks as labeled. Rs-13. BLOcK suMMARy: 1 - proxima1 and distal margins; 2 and 3 - tumor full thickness to inked free radial serosal surface; 4 and 5 - GROSS DESCRIPTION central tumor; 6 - tumor to normal; 7 - Icv; 8 and 9 - random bisected largest lymph node. MICROSCOPIC DESCRIPTION A&B. Microscopic examination performed. C. Histologic type:  Invasive adenocarcinoma
+
+--- Page 3 ---
+Histologic grade: Moderately differentiated Primary tumor (pT): Tumor minimally invades the subserosa, pT3a/b Proximal margin: Negative Distal margin: Negative Circumferential (radial) margin: Negative Distance of tumor from closest margin: 20 cm from distal margin Vascular invasion: Negative Regional lymph nodes (pN): All 16 lymph nodes negative for metastatic disease, 0/16, pNO Non-lymph node pericolonic tumor:  None Distant metastasis (pM): Cannot be assessed Other findings: Normal appendix 14, 4x2, 5 DIAGNOSIS A. Left tube and ovary, left salpingo-oophorectomy -- Serous cystadenofibroma of ovary. Attached fallopian tube, no significant pathology.. B. Uterus, cervix, right tube and ovary, total hysterectomy and right salpingo-oophorectomy -- Uterus with atrophic endometrium. Cervix with endocervical polyp. Attached atrophic right ovary with several inclusion cysts; right fallopian tube, no significant pathology. DIAGNOSIS C. Right colon, right hemicolectomy -- Moderately differentiated adenocarcinoma of the right colon, pT3. All margins are negative for tumor. All 16 regional lymph nodes are negative for metastatic disease. Appendix and portion of ileum, no significant pathology.
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diff --git a/output/text/38eba28e-9981-447c-95bf-80da176e4f52.txt b/output/text/38eba28e-9981-447c-95bf-80da176e4f52.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d3a8e1401de39c27d911ba225dcfe6f1116bace1
--- /dev/null
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+--- Page 1 ---
+UUID: 350810AF-C17B-41DA-BB21-A672DBB68382 TCGA-FV-A2QQ-01A-PR Redacted Patient Results SURGICAL PATHOLOGY REPORT ACCESSION NO. : Final Diagnosis(es): (A) Lymph node, biopsy: 1) Vascularized fibroadipose tissue with no histopathologic abnormality. 2) No lymphoid tissue present. (B) Gallbladder, cholecystectomy: 1) Chronic cholecystitis with cholelithiasis. 2) One periductal lymph node, negative for metastatic  malignancy (0/1). C) Liver, biopsy: 1) Moderate steatosis. 2) No evidence of steatohepatitis. lCs-0-3 2) Cirrhosis (Stage IV fibrosis), confirmed by the trichrome ca cinonn, hypatotllulud, Nos 8170f3 stain.  (D) Liver, mass-segments 4 and 5, partial hepatectomy: Sit 1) Hepatocelluiar carcinoma. lww c2s.0 l 2) The tumor measures 7.0 cm in greatest dimension.. 9/3/u 3) The tumor extends to within 1 millimeter of the surgical margin of resection. 3) See Synoptic Report below. COMMENTS: Synoptic Report: Specimen: Liver Procedure: Partial hepatectomy (segments 4 & 5) Tumor Size: 7.0 cm in greatest dimension Tumor focality: Solitary (Segments 4 & 5) Histologic type: Hepatocellular carcinoma  Histologic grade: Grade ll, moderately differentiated . Tumor extension: Tumor confined to the liver. Margins: Parenchymal margin: tumor is within 1 mm of the inked surgical parenchymal margin Lymphovascular invasion:. Macroscopic/large vessel invasion: not identified. Microscopic/small vessel invasion: not identified. Pathologic stage: pT1N1. Regional lymph nodes involved by tumor: none (0) Additional findings: Cirrhosis. ' The gross description and all microscopic slides have been reviewed and intarnroted by the undersigned pathologist' Electronically Signed , M.. (Resident) Specimen(s) Received: A: Lymph node 8: Gallbladder C: Liver biopsy Printed from: Default! Page: 2 of 4
+
+--- Page 2 ---
+Patient Results D: Liver mass Clinical History: Hepatoceilular carcinoma. Intraoperative Consultation: Time Received: 14:50 Time Reported: 15:10 D: Liver mass: Approximately 1 mm from margin (0 blocks) (Gross examination only). MD M.D. (Resident) Gross Description: (A) (lymph node) Received in formalin are two fragments of yellow-tan firm tissue measuring 0.4 x 0.3 x 0.2 cm and 1.5 x 0.7 x 0.5 cm. The smaller specimen is inked black and submitted entirely in A1 along with the larger specimen, which is uninked and bisected. (B) (gallbladder) Received in formalin is a previously unopened 9.4 x 5.0 x 5.0 cm gallbladder. The serosal surfaces are purple-tan and glistening. The gallbladder has a wal! measuring 0.2 cm. The mucosal surfaces are green and velvety. The gallbladder contains green bile and four large firm yellow stones ranging in size from 1.5 x 1.5 x 0.5 cm up to 3.5 x 3.5 x 2.8 cm. A cross-section of the cystic duct and a representative section of the wall are submitted in B1 along with a section of a 1.5 cm greatest dimension lymph node candidate. (C) (liver biopsy) Received in formalin are two tan tissue cores measuring 0.1 cm in diameter and ranging in length from 0.4 to 2.1 cm. The specimen is submitted entirely in C1. (D) (liver mass) Received fresh for intraoperative. consultation is a 10.0 x 6.0 x 4.0 cm portion of liver. One side is cauterized and the capsular surface is gray-tan with a smooth serosa but a macronodular surface. The resection margin is inked black. Sectioning through the specimen reveals a yellow lobulated soft tissue mass measuring 7.0 x 5.0 x 3.0 cm and appears to abut the surgical resection margin but does not appear to penetrate through it. Representative sections are submitted in D1-D5 with D1-D2 containing tumor to the closest resection margin. A representative section of grossly uninvolved liver is submitted in D6.. Microscopic Description: Complete microscopic evaluation has been performed. Appropriately reacting controls have been performed and evaluated for all stains on this case as required.. Histopathology has a list of IH antibodies that are regulated as analyte specific reagents (ASR's). These assays were developed and their performance characteristics determined by the Histopathology Laboratory in the  at the They have not been cleared by the US. Food and Urug Administration. The FDA has determined that such clearance or approval is not necessary for the ASR's. These Printed from: Default Page: 3 of 4
+
+--- Page 3 ---
+Patient Results tests are not investigational and are used in standard clinica! care. In cases where Immunohistochemistry testing is performed. the foilowing antibodies and their respective clones may be used to determine therapy for the patient: EFGR(31G7). ER(SP1), PR(1E2), Her2neu(4B5), CD117(Po!y), CD20(L26). Unless otherwise stated in the report, all tissue tested for ERPR by IHC, Her2 by IHC and/or HER2 by FISH have been fixed as per ANP.22998 for a minimum of 6 hours and a maximum of 48 hours. ER, PR, Ki-67, p53 are reported as a semi-quantitative percentage of positively stained nuclei. Her-2/neu and EGFR are. scored as follows: No staining at all is scored as (0), weak, incomplete membrane staining in any proportion of cells is scored as (1+), less than strong but complete staining in any proportion of cells or complete strong staining in less than 30%. of cells is scored as (2+), and strong complete staining in more that 30% of cells is scored as (3+). Ail studies are performed. on tissue fixed in 10% neutral buffered formalin and embedded in paraffin unless otherwise stated in the report. Printed from: Default End of Report Page: 4 of 4
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new file mode 100644
index 0000000000000000000000000000000000000000..f791c542a9d5123a40b6e486d23582a37c69e01a
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@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+ UID: EDF0AEC5-33E5-48EB-AD7A-C2F0C49C05F0 TCGA-LN-A7HW-01A-PR Redacted IRB APPROVED Clinical Case Report. ID O-3 8870h3 thud J C15.4 Informed Consent ytJ 1o/0/i3 I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator Signature Date Clinical Information GENERAL INFORMATION Date of Birth (mm/dd/yyyy) Height Marital Status Race Temperature SingleMarried Gender Weight  Divorced  Widow  Blood Pressure Heart Rate Male   Female Q3/7 HISTORY OF PRESENT ILLNESS Chief Complaints: ~Tuhe e SWalloWinq ) vo ctl ch cncge Symptoms: Fever ) "foitiouo Clinical Findings: Performance Scale (Karnofsky Score):  100 Asymptomatic  80-90 Symptomatic but Fully Ambulatory 60-70 Symptomatic, in bed less than 50% of day  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden ...  20-30 Bed Ridden CURRENT MEDICATIONS Drug Dose Route Freguency Date (mm/dd/yyy) To 1 1 To 1 / To To To
+
+--- Page 2 ---
+PAST MEDICAL HISTORY Dlagnosis/Disease/Disorder/Infury Diagnosis Date Treatment Status OB/GYN HISTORY Menopausal Status Date of First Menses # of Pregnancies  Pre-menopausal  Peri-Menopausal Date of Last Menses # of Live Births  Post-menopausal Sirth Control:  Condom  Oral Contraceptive IUD  Hormone Replacement Therapy:  Other: SOCIAL HISTORY Environmental Hazards: Occupation: Smoking History TYPE Packs/day Duration When Quit Current Status DeTda) Li () (yrs)L wcth cs(h (y) YES ONO Alcohol Consumption Current Status TYPE Drinks/day Duration When Quit 2donls(day P YES ONO (yrs).Lscn[hSs4D (y) Drug Use U. TYPE Frequency Duration When Quit Current Status  yES NO (yrs) FAMILY MEDICAL HISTORY Relative Diagnosis Age of Diagnosis LAB DATA Result Test Result Date Test Date HIV Negative  Positive: CEA  Negative  Positive: Hep B Negative  Positive: CA 15-3   Negative  Positive: Hep C  Positive:  CA 19-9   Negative  Positive: Negative 1 AFP  Negative  Positive: PSA   Negative  Positive: Other: Other:  Negative  Positive:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+DIAGNOSTIC STUDIES Study Results Date Ultrasound X-Ray CT EndoscopyeA tisonuy was Joura in ce se>ophagu MRI Biopsy CLINICAL DIAGNOSIS  Preoperative Clinical Diagnosis. EQshageal cticeR Location of Suspected Involved'Lymph Nodes Location of Suspected Distant Metastasis Clinical Staging Date of Diagnosis TZ NO Mg Stage: II A-- Treatment Information SURGICAL TREATMENT Procedure Date of Procedure Peseitcr dl the. Primary Tumor Organ Detailed Location Size L= 8vpneFZes ZiinxR eicelle .thiea 3 x2 x/ cm Extension of Tumor Lymph Nodes Description Location of Lymph Nodes # of Lymph Nodes Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Organ  Detailed Location Size Surgical Staging T2 No M c Stage: NEOADJUVENT THERAPY (Chemo, Radiation, Immuno, Hormonal, or Molecular) Drug/Treatment Dose Route Frequency Date (mm/dd/yyyy) To To 1 To 1 1 To 1 / To. 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Date: . Time: Collected by: Date:. Time: Preserved by: SPECIMEN TYPE (# of samples provided) Paraffin Block  Blood/Serum/Plasma  Slide Frozen Normal Diseased Normal Diseased Normal Diseased Normal Diseased 2 2 2 4 Time to LN2 Time to Formalin Time to LN2 min min min 13 PATHOLOGICAL DESCRIPTION Primary Tumor Size Extension of Tumor Distance to NAT Organ 6 3 x 2 x4 cmmidllle Mhird cm Aeems Lymph Nodes # Examined # Metastasized Location Distant Metastasis Detailed Location Size Organ Pathological Staging NO pT 2 Stage: I Notes: 4
+
+--- Page 5 ---
+IRS APPROVED Consolidated Pathology Diagnosis ID#: Cell Distribution + Structural Pattern Diffuse + 1. Streaming Mosaic  Storiform Necrosis Y Fibrosis Lymphocytic Infiltration Y Pallsading. Vascular Invasion Cystkc Degeneration Clusterized  Bleeding Alveolar Formation  Myxoid Change  Indian File XPsammoma/Calcification  Squamous Adenomatous +-  Sarcomatous +  Squamoid Cell Lymphomatous Glandular celf + Round Cell  Large Cell Spindle Cell Cell Stratification Fibroblast Small Cell  Keratin Secretion Osteoblast  RS Cell/RS Like Desmosome Intracyt. Vacuole Lipoblast Peart Inflam. Cell  Gland formation Myoblast Plasma Cell Cellular Differentiation: o Well  Moderate  Poor Nuclear Atypla: 0 1 II  Aniso Nucleosis III X Hyperchromatism Nucleolar Prominent X Multinucleated Giant Cell Mitotic Activity Nuclear Grade: x Final Pathology Report Comments: D1$87 br82 03407 546% Nsiewst 297 Date Director, Research Pathologye hw 8/3/3 INTEGRATED REPORT OF FINDINGS BY COLLABORATORS AND Criteria PATHOLOGISTS Diagnosis Discrepancy Primary Tumor Site Discrepancy HIPAA Discrepancy
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new file mode 100644
index 0000000000000000000000000000000000000000..a5f4cc3c67602f7eaf08e39e323357807dcccdfa
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:63F5F3D8-6393-4DA7-BB74-7D587199D7FD tcgA-A7-a3Iy-01a-pr  Redacted Final Surgical Pathology Report Procedure: Diagnosis A. Breast, right, excisional biopsy: Invasive mucinous car Nottingham grade 1 Note: The inked margins are negative for malignancy. Carcinoma is focally 0.3 mm from the superior margin. B. Breast, right, new lateral margin, biopsy: Fibrocystic changes. Negative for malignancy. c. Sentinel lymph node, biopsy: A single lymph node is negative for malignancy. 1tD-c-3 Microscopic Description: A. Invasive carcinoma:. c50.9 Histologic type: Mucinous carcinoma Site : bresst, Nus lu) Nottingham grade: 1 Architectural score:. 1 Nuclear score: 1-2 Mitotic score: Mitotic index: 1 mitoses/ 10 HPFs (1 HPF = 1.96 sq. mm) Tumor size: 1.3cm Specimen margins: Negative for malignancy. Carcinoma is focally 0.3 mm from the yellow (superior) inked margin in block Al. Vessel invasion: Absent Calcification: Absent Non-tumorous breast:  Fibrocystic changes including apocrine metaplasia, cyst formation, intraductal epithelial hyperplasia without atypia, columnar metaplasia, benign calcification and intraductal papilloma. TNM stage: T1c Prognostic markers:  See previous biopsy B. sections of the right breast lateral margin specimens show focally florid intraductal epithelial hyperplasia without atypia and other mild fibrocystic changes. The specimen is negative for malignancy. C. A single lymph node is negative for malignancy. [At the request of some staff oncologists and in keeping with the opinion of some experts in breast pathology, immunohistochemical stains for keratin were not used on the sentinel lymph node sections in this case. These stains can be obtained if desired. Our paraffin blocks are retained for 10 years. (Weaver DL et al. New Engl J Med 364:412, 2011. Schwartz GF et al. Cancer 94(10):2542, 2002)l. Specimen A. Right breast tissue long lateral short superior B. Right breast lateral margin. c. Sentinel lymph node Clinical Information Mucinous carcinoma
+
+--- Page 2 ---
+Gross Description The specimen is received unfixed in a Transpec container labeled right breast tissue long lateral short superior it consists of a yellow piece of soft tissue measuring 6.3 by 4.6 cm. The external surface the specimen is inked as indicated below.. Anterior: Red. Posterior:  Orange Lateral: Blue Medial: Green Superior:  Yellow Inferior: Black There is a palpable mass in the specimen measuring 1.5 cm in diameter the external palpation on cut section the mass 1.3 cm in diameter and has a mucoid appearance. A portion of the tumor is taken for research purposes. Sections after fixation. Rs8. Received unfixed labeled right breast new lateral margin short anterior 2.5 x 1 cm. The external surface the specimen is exhibited below. Anterior: Red. Posterior:  Orange Lateral: Blue Medial: Green Superior: Yellow Inferior: Black Sections after fixation. Rs7. Specimen c. is received in formalin labeled central lymph node and consists of a piece of yellow soft tissue measuring 3 x 2.5 x 0.6 cm. AS-2
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diff --git a/output/text/391351be-7384-4b72-8455-979dc7c656de.txt b/output/text/391351be-7384-4b72-8455-979dc7c656de.txt
new file mode 100644
index 0000000000000000000000000000000000000000..58c66ccc058f241760a20f2c67d0d96c8dc343d7
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+IcD0-3 renal ceQQ 'asineme, yayulseiy 8Q60|3 Operative Procedure: Right DA Vinci partial nephrectomy Op a/3[J4 Specimen Received: Right renal mass (FS) UUID:B64C5597-E57A-4ED3-9B02-D5A1D3011438 TCGA-GL-A9DD-01A-PR Redacted Final Pathologic Diagnosis:. Kidney, right, Da Vinci laparoscopic partial nephrectomy: Tumor histologic type: Papillary renal cell carcinoma, type 1 Sarcomatoid features (%):. Not identified Tumor size: 2.4 cm (greatest dimension). Other dimensions: 2.3 x 2.3 cm Macroscopic extent of tumor:. Confined to the kidney Focality: Unifocal Number of tumors: 1 Fuhrman grade: 2 0f 4 Microscopic extent of tumor: Perinephric fat invasion: Not identified Renal sinus invasion:  Not applicable Other: Not applicable Renal vein involvement: Not applicable Adrenal gland present: No (If yes) Involved by tumor:  Not applicable (If yes) Direct invasion or metastasis:  Not applicable Cancer at resection margin:. No (If yes) Location(s): Not applicable Pathologic findings in nonneoplastic kidney:  None significant Hilar lymph nodes present: No (lf yes) Number involved/number present:  Not applicable Pathologic stage (2010) pT1a pNx pM-not applicable The examination of this case material and the preparation of this report were performed by the staff pathologist. Intraoperative Consult Diagnosis:. FSA:  Right renal mass: Margin not involved by tumor, gross only F/S TAT: Gross Description: Received without fixative labeled "right renal mass" is a 3.7 x 3.0 x 2.7 cm partial nephrectomy with minimal adherent perinephric fat. Definitive renal sinus is not identified. The parenchymal margin is previously inked black and perinephric fat green. Sectioning reveals a 2.4 x 2.3 x 2.3 cm
+
+--- Page 2 ---
+variegated tan-red to orange, heterogeneous, markedly hemorrhagic well delineated mass that abuts the capsule and comes to within 0.2 cm from the parenchymal margin. The uninvolved parenchyma is tan and homogeneous. A gross photograph is taken. Representative sections are submitted as follows: 1-2  mass to inked parenchymal margin; 3-4  mass to capsule; 5uninvolved parenchyma. Microscopic Description: The final diagnosis of each specimen incorporates the microscopic examination findings. END OF REPORT Surgical Pathology Report Taken DOB: Gender: M h 12117/1s
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diff --git a/output/text/39300b12-da35-4151-9948-658331239d1d.txt b/output/text/39300b12-da35-4151-9948-658331239d1d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..96d9bab0dda01a77c37f9469fd19be675dd72a0e
--- /dev/null
+++ b/output/text/39300b12-da35-4151-9948-658331239d1d.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis: Right-sided hemicolectomy preparation shows tumor-free resection margins with a tubular adenoma of the ascending colon with moderate dysplasia (synonym: low-grade intraepithelial neoplasia) and includes a moderately differentiated polypous adenocarcinoma of the cecum with infiltration of the perimuscular fatty tissue and several regional lymph node metastases (G2, pT3 L1 V0 locally R0 pN2 6/33).
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diff --git a/output/text/394db5c7-b1b0-478e-80dd-d640eb37e468.txt b/output/text/394db5c7-b1b0-478e-80dd-d640eb37e468.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b6eac0d6950aaa1a5f724612d7a8e5d2804e0293
--- /dev/null
+++ b/output/text/394db5c7-b1b0-478e-80dd-d640eb37e468.txt
@@ -0,0 +1,36 @@
+
+--- Page 1 ---
+UUID:BBA96852-E70C-4D37-A185-611F568BE900 TCGA-AC-A62V-01A-PR Redacted Patient Referring Physician: DOB Age: Gender:M Rel#: Hosp#: Provider Group Date ot Service: Date Received Inpatient. Case # Date Reported: ADDENDUM SURGICAL PAThOLOGy REPORT Addendum Information:. This addendum report is issued to the provide results of breast carcinoma biomarker studies, performed on the previous ultrasound-guided core needle biopsy of the primary breast carcinoma?  biomarker results. Estrogen receptor: 100% positive cells, strong intensity. Progesterone receptor: Less than 1% positive cells HER2: IHC score 0 Ki-67 proliferative index: 35% positive cells The above results are similar to the those obtained on the metastatic carcinoma in the left iliac bone ICd-o- NoS glues Diagnosis: ueenener, 85013 A. Left breast, prophylactic mastectomy: - Gynecomastia. * Unremarkable skin and nipple.. pahh(B) Yreast,cyeu-wter - Negative for malignancy.. Juodsof' C5O.4 B. RIGhT BReaSt, MODIfIeD rADICal MaSTEctOmy: 4S s|4/3 - Invasive ductal carcinoma, Nottingham grade 3.. - Tumor size: 4.7 cm in diameter.. - Focal features of invasive micropapillary carcinoma. * Ductal carcinoma in situ (DCiS), high nuclear grade.  Cribriform and papillary architecture. - Comedo necrosis and calcifications present.. - DciS present adjacent to invasive carcinoma, in lactiferous ducts, and focally in upper inner quadrant.. - Mastectomy margins are free of tumor.  Carcinoma is 0.2 cm from the deep margin, and is at least 2 cm from all other margins. - Metastatic carcinoma in 3 of 17 axillary lymph nodes. Case #: Page 1 Printed: This report contnues . Mr No, - Acct No. Patient Name - Pathology - Page 1/6 Page 1 Doc#1
+
+--- Page 2 ---
+Patient: Case # ADDENDUM SURGICAL PATHOLOGY REPORT - No extranodal extension is identified - Largest metastatic focus measures 1.3 cm in diameter.. - Gynecomastia. PATHOLOGIC TUMOR STAGING SYNOPSIS: Type and grade (invasive): Invasive ductal carcinoma, Nottingham grade 3. Primary tumor: pT2. Regional Iymph nodes: pN1a. Distant metastasis: pM1 (metastasis to iliac bone). Lymphovascular invasion: Present. Pathologic stage: IV. Margin status: Negative. Invasive Breast Cancer Tumor Staging Information AJCC Cancer Staging Handbook, 7th Ed., and CAP Protocol (revised June 2012).. Previous pathology specimens: (breast biopsy) left iliac bone biopsy). Case# Page 2 Printed: Thus teport contmmes . MR No. Acct No. atient Name - Pathology - Page 2/6 Page2 Dac#1
+
+--- Page 3 ---
+Patient: Case #: SPECIMEN IDENTIFICATION Procedure/specinen type: Modified radical mastectomy. Laterality: Right. Lymph node sampling: Lymph node dissection INVASIVE CARCINOMA TUMOR CHARACTERISTICS Histologic type: Invasive ductal carcinoma Tumor site; Upper outer quadrant. Tumor size; 4.7 cm. Tumor focality: Sing!e focus of invasive carcinoma. Histologic grade (Nottingham Score) 30t 3 Tubule fornation: 3 of 3. Nuclear pleomorphism: 3 ot 3. Mitotic rate: 3 of 3. Lymphovascular invasion: Present. Macroscopic and microscopic extent of tumor: No skin or chest wall invasion identtied. DUCTAL CARCINOMA IN SITU (DCIS) high nuclear grade MARGINS Invasive carcinoma: 0.2 cm from deep margin, at least 2 cm from all Other margins. Ductal carcinoma in situ: at least 1 cm from all margins. LYMPHNODES Total lymph nodes examined. 17 Number of lymph nodes involved 3 Size of largest metastatic deposit: 1,3 cn. Extranodal extension: Not identified. PATHOLOGIC STAGING: Primary Tumor (pT): pT2. Regional lymph nodes (pN): pN1a Distant netastasis (pM):  pM1. AJCC Stage: IV, ANCILLARY STUDIES: ProPath, :  pertormed on bone biopsy Estrogen receptor: 100% positive cells, strong intensity. Progesterone rereptor? 0% positive cells. HER2: IHC score 1*. Ki-67: 15% positive cells. Case # Page.3 Printed: Ths report continues. MR No. - Acct No, - Patient Name - Pathology - Page 3/6 Page 3 Dor# 1
+
+--- Page 4 ---
+Patient: Case # ADDENDUM SURGICAL PATHOLOGY REPORT Source of Specimen:. A. Breast:left complete mastectomy B. Breast;right modified radical rnastectomy Clinical History/Operative Dx: None provided. Gross Description:. A. The specimen is labeled left breast complete mastectomy and is received in formalin. It consists of a. mastectomy specimen which weighs 227 grams. A black suture with a metallic clip marks the "tail ot the. breast". With this orientation the specimen measures 18.5 cm from medial to lateral, 11.8 cm from superior to inferior, and 2.5 cm superficial to deep. There is an overlying broad ellipse of dark brown skin. which ineasures 17 x 6.5 cm. Centrally and slightly superiorly within the skin is a 2.3 cm areola and a protuberant O.7 cm nipple. The anterior-superior margin is inked blue, the anterior-inferior nargin is inked. green and the posterior margin, which consists of smooth fascial tissue, is inked hlack. The specimen is serially sectioned at close intervals to reveal lobulated fatty tissue and centrally located. tan-white fibrous parenchyma. There are no areas which have a stellate or retracted appearance suggestive of neoplasm. In the lateral portion of the specinen, 2 cm from the lateral edge, there is a circumscribed 0.7 cm pale red lymph node. Representative sections are submitted. Section summary: A1) nipple and tissue just deep to nipple, A2) representative upper inner quadrant, A3) representative lower inner quadrant, A4) representative upper outer quadrant A5) representative lower outer quadrant, A6) representative central breast and representative cent:al deep margin, A7) lateral lymph node.. Case# Paye 4 Printed: Ihis repont cortntes. MR No. Acct No. - Patient Name - Pathology - Page 4/6 Page4 Doc#1
+
+--- Page 5 ---
+Patient: Case #: ADDENDUM SURGICAL PATHOLOGY REPORT 8. The specimen is labeled right breast modified radical mastectony and is yeceived without fixative. It consists of a mastectomy specinen together with axillary tissue weighing 292 grams. The breast measures 16 cm trom medial to lateral, 9 cm from superior to interior and up lo 4 cm from superficial to deep. There is an overlying ellipse of dark brown skin whch neasures 15.5 x 7.6 cm. Slightly medially located within the skin is a circumscribed 2.5 cm areola and a protuberant 0.6 cm nipple, The skin is unremarkable.. Axillary tissue is present and measures 15 x 6.5 x 1.8 cm. The anterior-superior nargin is inked blue, the anterior-inferior nargin is inked green, and the posterior margin, which consists of smooth tacial tissue, is inked black. In the central lateral portion of the deep margin, there is a 3 x 0.5 cm band of skeletal muscle which is indicated by the surgeon as pectoralis inajor behind the tumor. The specimen is serially sectioned at close intervals to reveal a relatvely well-circumscribed. firm, tan-white tumor mass beginning directly underneath the nipple and extending laterally within the breast. This tumor mass measures 4.7 cm from medial to laleral, 4.5 cm from superior to inferior, and 3.5 cm from superticial to deep. This neoplasm is 3.5 cm fron the closest medial margin, 5 cm from the axillary tail. 2.5 cm from the closest superior margin,and 2.2 cm fron the closest inferior margin.Centrally,it is grossiy 0.2 cm from the closest deep margin and does not appear to extend into the small strin of pectoralis muscle. The remainder of the breast is composed ot soft fatty tssue without other palpable masses. Representative tumor and adjacent breast parenchyrna are obtained for research purposes. In the medial portion of the axillary tail, there is a prominent firm 1.5 cm lymph node suspicious for metastatic. involvement. Representative tissue from this lymph node is obtained for research purposes also. The axillary tissue is dissected for nodes. Representaitve sections are submitted.. Section summary: B1) nipple and tissue just deep to nipple,. B2) representative lateral skin overlying tunor, B3)medial edge of tumor, B4-B11) sections of tumor progressing from medial to lateral,. B12) section of tumor and closest approach lo deep margin,. B13).deep margin with pectoralis muscle, B14)representative upper inner quadrant, B15) representative lower inner quadrant,. B16) representative upper outer quadrant,. B17) representative lower outer quadrant,. B18) medial axillarynode (some submitted for research) 819) single node, multiply sectioned. B20) single node, multiply sectioned, 321) ono larger node, serially sectioned, two smaller nodes inked and bivalved,. 822) two nodes, serially sectioned (one inked). 323-B24) s:naller possible nodes; intact. Microscopic Description: A. Microscopic sections nave been examined. The mcroscopic tndings are retlected in the diagnosis rendered. B. Microscopic sections have been exarnined. The microscopic findings are retlected in ihe diagnosis Case t 1ge5 Printed: Ihis letert sonbnus. MR No. - Acct No. Patient Name Pathology - Page 5/6. : Page 5 Doc# 1
+
+--- Page 6 ---
+Patient Case #: ADDENDUM SURGICAL PATHOLOGY REPORT rendered. Final report originally signed bj Case# Printed: END OF REPORT (ADDENDUM) MR No. - Acct No. :. Patient Name - Pathology - Page 6/6. Page h Doc#1
+
+--- Page 7 ---
+Referring Physician: Natiant DOB:' Age: Gender:M Ref#: Hosp# Provider Group : Date of Service: Date Received: Inpatient Case # Date Reported: FINAL SURGICAL PATHOLOGy REPOrT Diagnosis: A. Left breast, prophylactic mastectomy: . Gynecomastia. - Unremarkabie skin and nipple.. - Negative for malignancy. B. RIGHT BREAST, MODIFIED RADICAL MASTECTOMY: - Invasive ductal carcinoma, Nottingham grade 3. - Tumor size: 4.7 cm in diameter.. - Focal features of invasive micropapillary carcinoma. - Ductal carcinoma in situ (DciS), high nuclear grade.. - Cribriform and papillary architecture. - Comedo necrosis and calcifications present. - DCiS present adjacent to invasive carcinoma, in lactiferous ducts, and focally in upper inner quadrant. - Mastectomy margins are free of tumor.. . Carcinoma is 0.2 cm from the deep margin, and is at least 2 cm from all other margins. - Metastatic carcinoma in 3 of 17 axillary lymph nodes. - No extranodal extension is identified.. - Largest metastatic focus measures 1.3 cm in diameter. - Gynecomastia. PATHOLOGIC TUMOR STAGING SYNOPSIS: Type and grade (invasive): Invasive ductal carcinoma, Nottingham grade 3. Primary tumor: pT2. Regional Iymph nodes: pN1a.. Distant mmetastasis: pM1 (metastasis to iliac bone). Lymphovascular invasion: Present. Pathologic stage: IV. Margin status: Negative. Case# Fane1 Printed: Ths repoit contnues.(I HAL) MR No. - Acct No. -- Patient Name - * Patho!ogy - Page 1/6 Page1 Ooc#1
+
+--- Page 8 ---
+Patient Case #: FINAL SURGICAL PATHOLOGY REPORT Invasive Breast Cancer Tumor Staging Information. AJCC Cancer Staging Handbook, 7th Ed., and CAP Protocol (revised June 2012) Previous pathology specimens:. I (breast biopsy). (left iliac bone biopsy).. Case4. Page 2 Printed: Ths ++pucoants. (FNA) MR No. Acct No Patient Name  T Pathalogy - Page 2/6 lob Page 2 Doc# 1
+
+--- Page 9 ---
+Patient: Case #: SPECIMEN IDENTIFICATION Procedure/specinen type: Modified radical mastectomy. Laterality: Rignt. Lymph node sampling: Lymph node dissection. INVASIVE CARCINOMA TUMOR CHARACTERISTICS Histologic type: Invasive ductal carcinoma. Tumor site: Upper outer quadrant. Tumor size: 4.7 cm. Tunor tocality: Single tocus of invasive carcinoma Histologic grade (Nottingham Score):. 3 of 3. Tubule formation: 3013. Nuclear pleomorphism: 3 013. Mitotic rate: 3 0f 3. Lyinphovascular jnvasion: Present. Macroscopic and microscopic extent ot tumor:. No skin or chest wall invasion identified.. DUcTAL CArCiNOMA In SiTU (DCIS): high nuclear grade MARGINS Invasive carcinoma: 0.2 cm trom deep margin, at least 2 cm from all. other margins Ductal carcinoma in situ at least 1 cm trom all margins LYMPH NODES Total lymph nodes examined 17 Number of lymph nodes involved 3 Size of largest metastatic deposil. 1.3 cm. Extranodal extension: Not identified PATHOLOGIC STAGING: Primary Tumor (pT): pT2. Regional lymph nodes (pN): pN1a Distant metastasis (pM): pM1. AJCC Stage: IV. ANCILLARY STUDIES: ProPath,  performed on bone biopsy). Estrogen receptor: 100% positive cells. strong intensity Progesterone receptor: 0% positive cells. HEr2: IHC score 1+ K67: 15% positive cells. Case # Page 3 Prnted: Th.s report continues.. (F INAL) MR No. Acct No Patient Name - Pathology - Page 3/6 Jo: Page3 Dgc# 1
+
+--- Page 10 ---
+Patient Case # FINAL SURGICAL PATHOLOGy REPORT Signed by Source of Specimen:. A. Breast;left complete mastectomy B. Breast;right moditied radical mastectomy. Clinical History/Operative Dx:. None provided Gross Description:. A. The specinen is labeled left hreast complete mastectomy and is received in tormalin. It consists of a. mastectomy specimen which weighs 227 grams. A black suture with a metallic clip marks the "tail ot the breast". Wth this orientation the specimen measures 18.5 cm from medial'to laleral, 11.8 cm from.  Superior to interior, and 2.5 cm superficial to deep, There is an overlying broad ellipse of dark brown skin  which measures 17 x 6.5 cm. Centrally and slightly superiorly within the skin is a 2:3 cin areola and a protuberant O.7 cm nipple. The anterior-superior margin is inked blue, Ihe anterior-interior margin is inked. green, and the posterior margin, which consists of smooth fascial tissue, is inked black.. *The specimen is seriaily sectioned at close intervals to reveal lobulated fatty tissue and centrally located tan-white fibrous parenchyma. There are no areas which have a stellate or retracted appearance. suggestive of neoplasin. In the laleral portion of the specinen, 2 cm from the lateral edge, there is a. circunscribed 0.7 cm pale red lymph node. Representative sections aie submitted. Section summary:. A1) nipple and tissue just deep to nipple, A2) representative upper inner quadrant.. A3) representative lower inner quadram,. A4) representative upper outer quadrant, A5) representative lower outer quadrant A6) representative central breast and representative central deep nargin,. A7) lateral lymph node. Case # Page 4 Prnted: This report conanues.(FINAL) MR No. . Acct No. - Patient Name - Pathology - Page 4/6 Job Page 4 Doc#1
+
+--- Page 11 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT B. The specimen is labeled right breast modified radical mastectomy and is received without fixative. It consists ot a mastectomy specimen together with axillary tissue weighing 292 grams. The breast measures. 16 cm trom medial to lateral, 9 cm from superior to inferior and up to 4 cm trom superticial to deep. There is an overlying ellipse ot dark brown skin which measures 15.5 x 7.6 cm. Slightly medially located within the skin is a circuinscribed 2.5 cm areola and a protuberant 0.6 cm nipple. The skin is unremarkable, Axillary tissue is present and measures 15 x 6.5 x 1.8 cm. The anterior-superior margin is inked blue, the anterior-interior margin is inked green, and the posterior margin, which consists of smooth facial tissue, is. inked black. In the central lateral portion of the deep margin, there is a 3 x 0.5 cm band of skeletal muscle. which is indicated by the surgeon as pectoralis major behind the tumor. The specimen is serially sectioned at close intervals to reveal a relatively well-circumscribed, firm, tan-white tumor mass beginning directly underneath the nipple and extending laterally within the breast.. This tumor mass measures 4.7 cm from medial to lateral, 4.5 cm from superior to inferior, and 3.5 cm trom. superficial to deep. This neoplasm is 3.5 cm from the closest medial margin, 5 cm fron the axillary tail. 2.5 cm trom the closest superior margin, and 2.2 cm from the closest nterior margin. Centrally, it.is grossly 0,2 cm irom the closest deep margin and does not appear to extend into the small strip of pectoralis muscle. The reinamder of the breast is composed of soft fatty tissue without other palpable masses. Representative tumor and adjacent breast parenchyma are obtained for research purposes. In the inedial portion of the axillary tail, there is a prominent firm 1.5 cm lymph node suspicious for metastatic invoivement. Representative tissue from this lymph node is obtained for research purposes also. The axillary tissue is dissected for nodes. Representaitve sections are subrnitted. Section summary:. B1) nipple and tissue just deep to nipple, B2) representative lateral skin overlying tumor B3) medial edge of tumor,. 34-B11) sections of tuinor progressing from medial to lateral. B12) section ot tumor and closest approach to deep margin. B13) deep margin with pectoralis muscle. 314) representative upper inner quadrant B15) representative lower inner quadrant, B16) representative upper outer quadrant, B17) representative lower outer quadrant, B18) medial axillary node (some submitted for research) 319) single node, multiply sectioned, B20) single node, multiply sectioned, B21) one larger node, serially sectioned, two smaller nodes inked and bivalved. B22) two nodes,serially sectioned one inked) 323-B24) smaller possible nodes, intact Microscopic Description:. A. Microscopic sections have been examined. The microscopic findings are retlected in tho diagnosis renderod. B. Microscopic sections have been exanined. The microscopic findings are reflected in the diagnosis Case #. Puge 5 Printed: This report contnues. (INAL) MR No. Acct No. Patient Name - Patnolcgy - Page 5/6 aqe 5 Dor#1
+
+--- Page 12 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGy REPORT rendered 4/2/13 y DISQUALIFIE Case # Page 0 Printed: END CF REPORT (FINAL) MR No. Acct No. r Patient Name  Pathology - Page 6/6 Page 6 1oc# 1
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diff --git a/output/text/3984d6ca-1ce1-4dc3-9b67-878fe3953c92.txt b/output/text/3984d6ca-1ce1-4dc3-9b67-878fe3953c92.txt
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index 0000000000000000000000000000000000000000..decd20446aac0fc8de6dca65e8c22ce0dd78a81c
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+--- Page 1 ---
+/cs -0-3 Cascnmu,nfi1mutng 1obulu,Nos 85sof3 Site: brust Nos c5o.9 hw 5/s9/1 UUID:F838EE81-0603-4181-98D3-209143024EF8 TCGA-D8-A27G-01A-PR Redacted page 1 / 1  Pathology copy No. 5 Date: Examination: Histopathological examination Internal invoice No. Cost of diagnostic procedure Examination No.: Patient: XXX PESEL: XXX Age: Gender: F Material: Multiple organ resection -jeft breast with axillary tissues Unit in charge:  Physician in charge: Material collected on Material received on: Expected time of examination: up to 8 working days Clinical diagnosis: Cancer of the left breast Examination performed on: Macroscopic description:  Left breast, sized 20 x 16 x 4 cm, removed along with axillary tissues sized 23 x 8 x 3 cm and a skin flap of 16 x 10.5 cm. Tumour  sized 2. x 2 x 2 cm found in the lower outer quadrant, located 2.5 cm from the lower boundary, 0.2 cm from the base and 2 cm from the skin. Lymph nodes 2 cm in length. Microscopic description: Carcinoma lobulare invasivum NHG2 (3 + 2 +1/ 10 mitoses/10 HPF, visual area diameter 0.55 mm).  Lesions of the type hyperplasia lobularis atypica (ALH). Glandular tissue showing lesions of the type mastopathia fibrosa et custica, hyperplasia ductalis simplex (UDH) papilloma intraductal. Axillary lymph nodes Sinus histiocytosis et lipomatosis lymphonodorum (No xxxi). Histopathological diagnosis: Carcinoma lobulare invasivum mammae sinistrae. Invasive lobular carcinoma of the left breast. (NHG2, pT2, pNO). Compliance validated by:
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diff --git a/output/text/39a45891-c744-4297-af34-a6345367fe4d.txt b/output/text/39a45891-c744-4297-af34-a6345367fe4d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..30e279900f08ed8506e02ac470b3bdf3458f601f
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+
+--- Page 1 ---
+Patient history: No clinical history is given.. Pre-op DiagnOsis: Left renal lesion. pOST-Op DIAGNOSIS: Same PROCEDURE: Laparoscopic assisted left nephrectomy. FINAL DIAGNOSIS: Kidney, Left, nephrectomy - A.  Renal cEll Carcinoma, cLear Cell type B.  FUHrMAn NUCLEAR GrADE IS 3 of 4. C. The greatest Diameter of the neoplAsm Is 6.0 cm.  The neoplasm does not involve the perirenal Or peripelvic fat. E.  THe NeOpLASm GrO$SLy eXTenDs iNtO The reNAL VEin anD But IS nOt PrESEnt At The RENAL VEIn MARGIN F. ALL $URGICAL MARGINS ARE FREE OF THE NEOPLASM. G.  NON-NEOPLASTIC KIDNEY SHOWS CHrONIC INTERSTITIAL INFLAmmATION, GLOmErULOSCLEROSIS, AND THYROIDIZATION. H. TNM STAGE: pT3b NX MX. CASE SYNOPSIS: SYNOPTIC DATA - PRIMARy KIDNEy TUMORS SpECimen type:  Radical nephrectomy LATERALITY: Left Tumor SiTe: Lower pole FOCALITY: Unifocal TUmOr SIZe: Greatest dimension: 6.0 cm. Additional dimensions: 6.0 crn MAcrOsCOpic eXTeNt Of tumOr: Tumor extension into major veins HISTOLOGIC TYPE: Clear cell (conventional) renal carcinoma HISTOLOGIC GRADE (Fuhrman Nuclear Grade): G2 PATHOLOGIC STAGING (pTNM): pT3b pNX Number of regional lymph nodes examined: 0 pMX MARGINS:  Margins uninvolved by invasive carcinoma ADRENAL GLAND: Not present VEnOUS (LArGe vESSeL) invasION (V): Absent LYmphATiC (SmALL VESSeL) InVAsION (L): Absent ADDITIONAL PATHOLOGIC FiNDINGS: Glomerular disease (type): GLOMERULOSCLEROSIS Interstitial disease (type): CHRONiC INFLAMMATION Other: THYROIDIZATION
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diff --git a/output/text/39cec58f-4e66-40a4-993f-243402719907.txt b/output/text/39cec58f-4e66-40a4-993f-243402719907.txt
new file mode 100644
index 0000000000000000000000000000000000000000..19a3f138dfe0716b2fcc47b6c02ac10ffdbb599d
--- /dev/null
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+
+--- Page 1 ---
+Clinical Diagnosis & History: Right breast cancer on cone biopsy and left breast abnormality for right TM, SLNE, possible right ALnp, ard ieft breast aeedle localization and excision. Specimens Submitted: 1: SP: Sentinel node #1 level 1 right axilla 2: SP: Non-sentinel right axilla. 3: sp: Left breast sermental resect-on 4: Sp:  Right breast DIAGNOSIS: 1) SENTINEL NODE #1, LEVEL I. RIGHT AXILLA; SIOPSY: ONE BENIGN LYMPH NODE O/1). - DEEPER LEVEL RECUTS AND SPECIAL STAINS HAVE BEEN ORDERED. THE RESULTS WILL BE REPORTED IN AN ADDENDUM. 2) NON-SENTINEL LYMPH NODE, RIGHT AXILLA; BIOPSY: ONE BENIGN LYMPH NODE (C/). 3) BREAST, LEFT; SEGMENTAL RESECTION:  BREAST TISSUE SHOWING DUCT HYPERPLASIA WITHOUT ATYPIA AND STROMAL FIBROSIS. 4) BREAST/ RIGHT) MASTECTOMY:S INVASIVE_DUCTAL CARCINOMA WITH A SOLID PAPILLARY ARCHITECTURE. 3 HISTOLOGIC GRADE III/III (SLIGHT OR NO TUSULE FORMATION), NUCLEAR GRADE II/III (MODERATE VARIATION IN SIZE AND SHAPE, MEASURING 2.3 CM IN LARGEST "J+xfo! DIMENSION GROSSLY - DUCTAL CARCINOMA IN SITU (DCIS) IS ALSO IDENTIFIED, SOLID TYPE WITH INTERMEDIATE NUCLEAR GRADE AND MINIMAL NECROSIS. - THE DCIS CONSTITUTES <2S% OF THE TOTAL TUMOR MASS AND IS PRESENT AWAY FROM THE INVASIVE COMPONENT. my - THE INVASIVE CARCINOMA IS LOCATED IN THE UPPER AND LOWER INNER QUADRANTS AND CENTRAL THE DCIS IS LOCATED IN THE CENTRAL AREA. AREA. NO INVOLVEMENT OF THE NIPPLE BY EITHER IN SITU OR INVASIVE CARCINOMA IS IDENTIFIED. - NO CALCIFICATIONS ARE IDENTIFIED IN EITHER THE INVASIVE OR IN SITU ** Continued on next page ** SON Ft- 0-(>1 C OInn :rf!s
+
+--- Page 2 ---
+COMPONENT . - NO VASCULAR INVASION IS NOTED. - NO INVOLVEMENT OF THE SURGICAL MARGINS BY EITHER INVASIVE OR IN SITUS CARCINOMA IS IDENTIFIED. - NO SKIN INVOLVEMENT BY CARCINOMA IS IDENTIFIED. - THE NON-NEOPLASTIC BREAST TISSUE SHOWS BIOPSY SITE CHANGES.S - RESULTS OF SPECIAL STAINS (ER, PR, HER2-NEU AND NEUROENDOCRINE) MARKERS) WILL BE REPORTED AS AN ADDENDUM. NOTE: HAS REVIEWED THE CASE AND CONCURS. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL). AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. *** Report Electronically Signed Out Special Studies: Result Special stain AEl:AE3 Comment NEG CONT IMM RECUT RECUT RECUT RECUT RECUT ER-C pR-c HER2-C CHR SYN CD56 E-CADHERIN NEG-HER2 NEG CONT IMM RECUT RECUT Gross Description: 1) The specimen is received fresh for frozen section, labeled -Sentinel. Node #1 Level 1 Right Axilla". surrounded by adipose tissue. Sntirely frozen. It consists of a 0.6 cm lymph node Summary of Sections:. Fsc - frozen section control +* Continued on next page
+
+--- Page 3 ---
+3) The specimen is received fresh for frozen section, labeled. *Non-sentinel Right Axilla'. It consists of a 1.8 cm lymph node, sectioned and entirely submitted. Summnary of Sections: FSCA -' frozen section control A FSCB  - frozea section control B 3) The specimen is received fresh. labeled "Left Breast Segmental. Resection (short stitch superior, long stitch lateral)". It consists of a 4.5 x 3.8 x 0.9 cm irregular fragment of fibroadipose tissue oriented with a long suture for the lateal and a short suture for the suporior aspect. specimen is inxed with standard colors: anterior - yellow, posterior black, inferior - xed and superior - blue. Serial sections reveal a mostly The tibrous appearance on cut surface with focal adipose areus. identifiable mass is seen. submitted. The specimen is serially sactioncd and entirely.  No gross Sumary of Scctions: LM - lateral margin MM - medial margis S serial sections from the lateral to medial aspect. 4) The specimen is received fresh, labeled "Right Breast (stitch marks axillary tail)". It consists of a 22.5 x 16.3 x 3.2 cm breast, oriented with a stitch for the axillary tail and displaying a centrally located areola.  The ellipse of skin measures 8.5 x 6 cm with a centrally located 1.5 x 0.6 cm unremarkable nipple. Of adipose tissue are labeled *Go with Breast*, measuring 3.5 x 2.5 x 0.5 In the same container, multiple fragments cm. Serial sections of the breast parenchyma reveal a 2.3 x 2.1 x 1.5 cm, centrally. retroareolar, on the upper inner and lower inner quadrants. and is located at 2.3 cm from the deep margin. is yellow, lobular, mostly with focal areas of fibrosis. The uninvolved breast parenchyna sections are submitted. The axillary tail is dissected and several possible. lyuph nodes are submitted. Representative A representative section is submitted fox Tps. Summary of Sections: N - nipple  sections of the tumor including the deep margin. UIQ upper ianer quadrant UOQ upper r outer quadrant LIQ lower innar quadrant L0Q lower outer quadrant GWB tissue labeled "go with breast" LN- possible lyuph nodes ** Continued on next page *
+
+--- Page 4 ---
+Suaunary of Sections: Part 1: SP: Sentinel  node #1 level 1 right axilla Block Sect. Site 1 pCs fsc 0 Part 2:  SP: Non-sentinel right axilla Block Sect. Site 1 PCs {not entered} 1 fsc Part 3: Block Sect. Site 2 PCs 1m 2 8 srun 0 Part 4: SP Right breast Block Sect. Site 1 2 PCs swb 1iq 6 3 224 LN 1oq 6 0 2 2 uoy Procedures/Addenda: Addendum Date Ordered: Date Complete: Status:  Signed Out Date Reported: By: Addendum Diagnosis ADDENDUM SITE: SENTINEL LYMPH NODE #1. LEVEL I. RIGHT AXILLA: PART #1.  ADDITIONAL H&E STAINED SECTIONS AND IMMUNOHISTCCHEMICAL STAINS FOR CYTOKERATINS (AEI:AE3) SHOW NO EVIDENCE OF METASTATIC TUMOR. * Continued on next pag
+
+--- Page 5 ---
+5 Addendun Date Ordered: Date Complete Status: Date Reported. Signed Out By: Addendum Diagnosis ADDENDUM SITE: RIGHT BREAST PART #4. ER 95% OF NUCLEAR STAINING WITH STRONG INTENSITY. 95% OF NUCLEAR STAINING WITH STRONG INTENSITY. HER2/NEU (HERCEPTEST) : NEGATIVE (STAINING INTENSITY OF O).) CONTROLS ARE SATISFACTORY. Addendum Date Ordered: Date Complete: Status: Signed Out Date Reported: By: Addendun Diagnosis ADDENDUM SITE: LEFT BREAST PART #3 - CALCIFICATIONS ARE PRESENT IN SENIGN DUCTS AND CRYSTALS CONSISTENT WITH CALCIUM OXALATE ARE PRESENT IN APOCRINE CYSTS. Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation.. *+ Continued on next page **
+
+--- Page 6 ---
+FROZEN SECTION DIAGNOSIS: PERMANENT DIAGNOSIS: SAME. NEGATIVE LYMPH NODE. 2A) FROZEN SECTICN DIAGNOSIS: NEGATIVE LYMIPH NODES (2 SECTIONS). PERMANENT DIAGNOSIS: SAME. 28) FROZEN SECTION DIAGNOSIS: NEGATIVE LYMPH NODES (2 SECTIONS). PERMANENT DIAGNOSIS: SAME. End of Report.
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diff --git a/output/text/39e1df97-a7f4-4da0-8216-43a024819cc8.txt b/output/text/39e1df97-a7f4-4da0-8216-43a024819cc8.txt
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index 0000000000000000000000000000000000000000..a178fc388408b84275b33f5a9cc72d1592577723
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+TSS ID JCA-0-3 SPECIMENS: Ca^cinoma vifi#mutnq dlucthl Nos 850of3 A. RIGHT BREAST LESION B. ADDITIONAL POSTERIOR MARGIN Sih:buast Nos c50.9 C. LEFT BrEAST CANCER /8 D. ADDITIONAL POSTERIOR -LATERAL MARGIN E. SENTINEL L.N. LEFT AXILLA #1 F. SENTINEL L.N. LEFT AXILLA #2 G. SENTINEL L.N. LEFT AXILLA #3 UUID:4F2A288E-8162-4579-8CD2-0FF31B0EEB3C H. SENTINEL L.N. LEFT AXILLA #4 TCGA-E2-A1II-01A-PR I. SENTINEL L.N. LEFT AXILLA #5  Redacted J. ADDITIONAL INFERIOR MARGIN K. ADDITIONAL POSTERIOR MARGIN SPECIMEN(S): A. RIGHT BREAST LESION B. ADDITIONAL POSTERIOR MARGIN C. LEFT BREAST CANCER D. ADDITIONAL POSTERIOR -LATERAL MARGIN E. SENTINEL L.N. LEFT AXILLA #1 F. SENTINEL L.N. LEFT AXILLA #2 G. SENTINEL L.N. LEFT AXILLA #3 H. SENTINEL L.N. LEFT AXILLA #4 I. SENTINEL L.N. LEFT AXILLA #5 J. ADDITIONAL INFERIOR MARGIN K. ADDITIONAL POSTERIOR MARGIN INTRAOPERATIVE CONSULTATION DIAGNOSIS: A. Right breast: An ill-defined firm area about 0.3cm from posterior margin, additional margin B received (gross only). C. Left breast: 1.7 x 1.5 x 1.3 cm nodule tocated 0.1-cm from posterior and inferior junction. . Sentinel lymph nodes, left axilla, #1-5: Lymph nodes, negative for tumor on touch preparation. Diagnoses called to Dr. at i. (A). (C) .. (E-1) by Dr.. GROSS DESCRIPTION: A. RIGHT BREAST LESION Received fresh labeled with matching patient identifiers is an oriented (single-anterior, double-iateral, triple-superior) 20g, 5.2 x 4.9 x 1.6 cm lumpectomy with 1.4 x 0.3 cm skin elipse accompanied by mammograms. The specimen is inked as follows: Anterior-blue, posterior-black, superior-red, inferior- orange, medial-green, lateral-yellow. The specimen is serially sectioned from medial to lateral into 5 slices revealing a 1 x 0.5 x 0.5 cm ill-defined firm hemorrhagic area approaching the closest posterior margin at 0.3cm. The entire specimen is submitted for microscopic evaluation: A1: Medial margin A2-A3: Section 2 entirely submitted A4-A6: Section 3, A6 demonstrates ill-defined firm area A7-A9: Section 4 entirely submitted A10-A13: Lateral margin B. ADDITIONAL POSTERIOR MARGINE Received in formalin in a container labeled with matching patient identifiers is a 2.6 x 2.4 x 1.1cm breast tissue with orientation, the suture designating the final posterior margin. This area is inked black. The specimen is serially sectioned and submitted entirely in cassettes B1-B4. C. LEFT BREAST Received fresh labeled with matching patient identifiers is an oriented (single-anterior, double-lateral, triple-superior, quadruple-posterior) 94g, 9.6 (anterior to posterior) x 7.5 x 4.4 cm lumpectomy. The specimen is inked as follows: Anterior-blue, posterior-black, superior-red, inferior-orange, medial-green, Iateral-yellow. The specimen is serially sectioned from anterior to posterior into 7 slices revealing a 1.7 x 1.5 x 1.3 cm firm tan circumscribed round mass closest to the posterior/inferior margin at 0.1cm. A second possible 0.5 x 0.3 x 0.3 cm nodule is palpated 0.5cm from the main mass that approaches the posterior margin at 0.2cm. A portion of the specimen is submitted for tissue procurement. Representatively submitted as follows:. C1: Representative sections anterior margin, slice 1 C2: Representative section, slice 2 superior. C3-C4: Representative sections, slice 3, lateral and inferior
+
+--- Page 2 ---
+TSs Il C5-C6: Representative sections, slice 4, medial and inferior C7-C13: Slice 5 entirely submitted, C10-C11, mass, C12-C13, possible nodule C14-C19: Slice 6 entirely submitted, C14-C17, mass (procured), C18-C19 posterior. C20-C21: Posterior margin submitted entirely, slice 7 D. ADDITIONAL POSTERIOR LATERAL MARGIN Received in formalin in a container labeled with matching patient identifiers is a 4.2 x 2.7 x 1.6 cm breast tissue with orientation, the suture designates the fina! posterior lateral margin. This area is inked black. The specimen is serially sectioned and submitted entirely in D1-D6.. E. SENTINEL LYMPH NODE LEFT AXILLA #1 Received fresh labeled with matching patient identifiers is a fragment of adipose tissue measuring 2.5 x 2.4 x 0.5 cm. A possible lymph node is identified measuring 1.2 x 0.5 x 0.5 cm. Touch preparation is performed. The lymph node is submitted entirely in cassette E1. F. SENTINEL LYMPH NODE LEFT AXILLA #2 Received fresh labeled with matching patient identifiers is a fragment of adipose tissue measuring 3.3 x 2.5 x 0.7 cm. A possible lymph node is identified measuring 1.3 x 0.5 x 0.5 cm. Touch preparation is performed. The lymph node is submitted entirely in cassette F1. G. SENTINEL LYMPH NODE LEFT AXILLA #3 Received fresh labeled with matching patient identifiers is a fragment of adipose tissue measuring 2.9 x 2.5 x 0.4 cm. A possible lymph node is identified measuring 0.5 x 0.5 x 0.5 cm. Touch preparation is performed. The entire specimen is submitted in cassettes G1-G2. H. SENTINEL LYMPH NODE LEFT AXILLA #4 Received fresh labeled with matching patient identifiers is a portion of tan-yellow possible lymphoid tissue measuring 0.9 x 0.5 x 0.5 cm. The specimen is bisected. Touch preparation is performed. The entire specimen is submitted in cassette H1. 1. SENTINEL LYMPH NODE LEFT AXILLA #5 Received fresh labeled with matching patient identifiers is a portion of tan-yellow possible lymphoid tissue measuring 1.6 x 1 x 0.3 cm. The specimen is bisected. Touch preparation is performed. The entire specimen is submitted in cassette l1. J. ADDITIONAL INFERIOR MARGIN Received in formalin in a container labeled with matching patient identifiers is a portion of resected breast tissue measuring 3.2 x 2.6 x 0.6 cm. The specimen is received with orientation, the suture designates the final inferior margin. This area is inked black. The specimen is serially sectioned and submitted entirely in cassettes J1-J3.. K. ADDITIONAL POSTERIOR MARGINE Received in formalin in a container labeled with matching patient identifiers is a portion of resected breast tissue measuring 4.1 x 1.9 x 0.8 cm. The specimen is received with orientation, the suture designates the final posterior margin. This area is inked black. The specimen is serially sectioned and submitted entirely in cassettes K1-K3. RESULTS: SUMMARY OF IMMUNOHISTOCHEMISTRY/SPECIAL STAINS Material: Block  Population: Tumor Cells Stain/Marker:Result:  Comment: CYTOKERATIN AE1/3 Positive Material: Block E1 Population: Tumor Cells Stain/Marker:Result:  Comment: CYTOKERATIN AE1/3 Negative Material: Block F1 Population: Tumor Cells Stain/Marker:Result:  Comment: CYTOKERATIN AE1/3  Negative
+
+--- Page 3 ---
+Tss id . The interpretation of the above immunohistochemistry stain or stains is guided by published results in the medical literature, provided package information from the manufacturer and by internal review of staining performance and assay validation within the Immunohistochemistry Laboratory of the The use of one or more reagents in the above tests is regulated as an analyte specific reagent (ASR). These tests were developed and their performance characteristic determined by the t. They have not been cleared or approved by the U.S. Food ana Drug Administration. qy "ne FDA has determined that such clearance or approval is not necessary.  Special stains and/or immunohistochemical stains were performed with appropriately stained positive and negative controls. DIAGNOSIS: A. BREAST, RIGHT, NEEDLE LOCALIZED WIDE LOCAL EXCISION: - FOCAL ATYPICAL DUCTAL HYPERPLASIA. - FOCAL HEMORRHAGE, COLUMNAR CELL CHANGE, AND INTRADUCTAL MICROCALCIFICATIONS. - BENIGN SKIN. B. BREAST, RIGHT, ADDITIONAL POSTERIOR MARGIN, EXCISION: - BREAST TISSUE WITH FOCAL HEMORRHAGE AND USUAL DUCTAL HYPERPLASIA. C. BREAST, LEFT,NEEDLE LOCALIZED WIDE LOCAL EXCISION:  - INVASIVE DUCTAL CARCINOMA, POORLY DIFFERENTIATED (SBR GRADE 3), WITH MARKED LYMPHOCYTIC INFILTRATE. - TUMOR MEASURES 1.7 CM IN GREATEST DIMENSION. - TUMOR IS WITHIN 1 MM OF THE POSTERIOR AND INFERIOR MARGINS (SEE NOTE). NOTE: The final posterior and inferior margins are negative for tumor (see specimens J and K). D. BREAST, LEFT, ADDITIONAL POSTERIOR-LATERAL MARGIN, EXCISION: - BREAST TISSUE, NEGATIVE FOR CARCINOMA. E. SENTINEL LYMPH NODE #1, LEFT AXILLA, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR CARCINOMA (0/1) (SEE NOTE) F. SENTINEL LYMPH NODE #2, LEFT AXILLA, BIOPSY:  - ONE LYMPH NODE, NEGATIVE FOR CARCINOMA (0/1) (SEE NOTE). NOTE FOR E AND F: Cytokeratin AE1/3 stains were performed and are negative showing no evidence of metastases. G. SENTINEL LYMPH NODE #3, LEFT AXILLA, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR CARCINOMA (0/1). H. SENTINEL LYMPH NODE #4, LEFT AXILLA, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR CARCINOMA (0/1). I. SENTINEL LYMPH NODE #5, LEFT AXILLA, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR CARCINOMA (0/1). J. BREAST, LEFT, ADDITIONAL INFERIOR MARGIN, EXCISION: - BREAST TISSUE WITH USUAL DUCTAL HYPERPLASIA,
+
+--- Page 4 ---
+TSS ID NEGATIVE FOR CARCINOMA. K. BREAST, LEFT, ADDITIONIAL POSTERIOR MARGIN, EXCISION: - BREAST TISSUE WITH USUAL DUCTAL HYPERPLASIA, NEGATIVE FOR CARCINOMA SYNOPTIC REPORT - BREAST Specimen Type: Excision Needle Localization: Yes - For mass Laterality: Left Invasive Tumor: Present Multifocality: No WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Tumor size: 1.7cm Tumor Site: 3:00 Margins: Negative Tubular Score: 3 Nuclear Grade: 3 Mitotic Score: 2 Modified Scarff Bioom Richardson Grade: 3 Necrosis: Absent Vascular/Lymphatic Invasion:  None identified Lobular neoplasia: None Lymph nodes:  Sentinel lymph node only Lymph node status:  Negative 0/5 DCIS not present ER/PR/HER2 Resuits ER: Negative PR: Positive HER2: Negative by IHC Pathological staging (pTN): pT 1c N 0 SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimen:  Surgical Excision Block Number: Allred Score: 0 = Proportion Score 0 + Intensity Score 0 ER: Negative Allred Score: 4 = Proportion Score 2 + Intensity Score 2 PR: Negative COMMENT:  The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the. proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring range from 0 to 8. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2. METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. 1mmunohistochemistry was performed usina the mouse anti-human ER (ER 1D5, 1:100) and PR (PGR following the manufacturer s instructions. This. 136, 1:100) provided by assay was not modified. interpretation of the ER/PR immunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal review of staining performance.
+
+--- Page 5 ---
+TSS ID SYNOPTIC REPORT - BREAST HER-2 RESULTS Specimen: Surgical Excision Block Number: Interpretation:  NEGATIVE Intensity: 1+ % Tumor Staining: 5% Fish Ordered: No METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Her2 analvsis was performed using the FDA approved Dako HercepTest (TM) test kit using rabbit anti-human HER2. This assay was not modified. External kit-slides proviaeu vy ue inanufacturer (cell lines with high, low and negative HER2 protein expression) and in- house known HER2 amplified control tissue were evaluated along with the test tissue. Adequate, well preserved, clear-cut invasive carcinoma was identified for HER2 evaluation. Interpretation of the HER2 immunohistochemical stain is guided by published resuits in the medical literature, information provided by the reagent manufacturer and by internal review of staining performance. This assay has been validated according to the 2007 joint recommendations and guidelines from ASCO and CAP and from the NCCN HER2 testing in Breast Cancer Task Force. Pathology Department takes full responsibility for this test's performance. CLINICAL HISTORY: Lesion on core biopsy, right breast; Left breast carcinoma. PRE-OPERATIVE DIAGNOSIS: Breast carcinoma ADDENDUM: ONCOTYPE DX BREAST CANCER ASSAY RESULTS: Recurrence Score: 52 CLINICAL EXPERIENCE: Patients with a recurrence score of: 52 in the clinical validation study had an average rate of Distant Recurrence at 10 years of 34% Er Score: 3.7  Negative PR Score: 3.3 Negative Her2 Score: 7.6 6 Negative Interpretation: ER  Negative < 6.5 Positive >= 6.5 PR  Negative < 5.5 Positive >= 5.5 Her2 Negative <10.7 Positive >=11.5 Equivocal = 10.7 - 11.4 Gross Dictation: , M.D., Pathologist, Microscopic/Diagnostic Dictation: , M.D., Pathologis! Final Review: , M.D., Pathologist, Final: , M.D., Pathologist,. Addendum: , M.D., Pathoiogist, Addendum Final: , M.D., Pathologist
\ No newline at end of file
diff --git a/output/text/3a20c3d6-90ee-420f-93b3-154d0dba3265.txt b/output/text/3a20c3d6-90ee-420f-93b3-154d0dba3265.txt
new file mode 100644
index 0000000000000000000000000000000000000000..bd9ec362a024f6d2fa926ecf2b568b8a224fc28f
--- /dev/null
+++ b/output/text/3a20c3d6-90ee-420f-93b3-154d0dba3265.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis: Right hemicolectomy preparation with tumor-free oral and aboral resection margins and including an ulcerated, poorly differentiated adenocarcinoma of the ascending colon, with infiltration of the perimuscular fatty tissue and numerous regional lymph node metastases (G3, pT3, L1, V1 local R0 pN2 24/29).
\ No newline at end of file
diff --git a/output/text/3a332171-0fbe-4242-a490-188bfe0f9d73.txt b/output/text/3a332171-0fbe-4242-a490-188bfe0f9d73.txt
new file mode 100644
index 0000000000000000000000000000000000000000..536fc666fde40b377a6612f5b72d9c5e51d03072
--- /dev/null
+++ b/output/text/3a332171-0fbe-4242-a490-188bfe0f9d73.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:ADBA741B-AABF-4A33-A61F-C10EE555D175 TCGA-LD-A7W5-01A-PR Redacted Surgical Pathology Report * Amended * DATE OBTAINED: LOCATION: DATE RECEIVED: SUBMITTING MD: DAtE rEporTED: CC: DIAGNOSIS #1-AxilLARy COntents, LEft: twenty Three Lymph nODes POsItIve fOr metastaTIC CARcInOMA, LaRgeSt MEaSuRiNg 3.7 Cm wITH eXTRanODAL EXTeNSION (23/23). #2-bReaSt, Left, 2 O'clOck, excisiOnal BiOpsy: inVasive mammary CarcinomA. SIZE (INVASIVE): 2.8 cm LATERALITY: Left TUMOR FOCALITY: Unifocal LesionaL Site: 2 o'clock HISTOLOGIC TYPE: NUCLEAR GRADE: Agce III of III HISTOLOGIC GRADE(EEmSBR): II of III (Tubules score 2 + NG score 3 + mitoses score 1). IN-SITU COMPONENT: DCIS solid and cribrlform types, nuclear grade Ill with comedonecrosis. LYMPH NODE SAMPLING Twenty three lymph nodes positive for carcinoma (23/23). (see specimen #1) with extranodal extension, largest measuring 3.7 cm. AJCC CATEGORIES: Stage IIIC(assumlng "cM0" status) pTNM: pT2 pN3a CTNM: cT2 cN1 INTEGRITY/ORIENTATION: Intact specimen with designated margins MARGINS: Posltive posterior/superlor margin tocally (slide 2K, scut); medial margin 0.5 mm; other margins widely negative. LYMPHOVASCULAR INVASION: Present MICROCALCIFICATIONS: Present in association with in situ and invasive carcinoma. NIPPLE/SKIN: (if applicable) Not applicable. SKELETAL MUSCLE: Not present. OtheR: Biopsy site changes, tibrocystic changes. #3-BREASt, LEfT, DEep mArGIN, REEXCISION: 2 mm fOCUS OF RESIDUAl INVASIVe CARCInOMA PrESeEnt 4 mm FrOm FiNAl Deep MArGin; bACKgROuND PrOLiFErATIVE bREASt PAReNChymA WITH INTRADUCTAL PAPILLOMA. ICD o-3 ductNOS areinoms, inyiltroti ***Electronically Signed Out*** 8s00/3 C5s.9 HJ16/1s113 COMMENT The tumor was grossly measured as 2.4 cm with an additional tumor present at medial slice , not grossly appreciated; with an ~  4mm span to make the final dimension 2.8 cm. Page 1 of 3
+
+--- Page 2 ---
+Surgical Pathology Report The tumor is present 1 mm from deep margin in multiple foci at main specimen, and focally in slice 1K is present at.  posterior/superior margin; final deep margin (specimen #3) negative.. 88307 X 2, 88305 Clinical Diagnosis and History: Left breast Ca + LN met) cT2; cN1: Clinical Stage IIB Tissue(s) Submitted:. 1: LEFT AXILLARY CONTENTS 2: LEFT BREAST CANCER @ 2:00 (SUTURE MARKS ANTERIOR)E 3: LEFT BREAST TRUE DEEP MARGIN Gross Description: Specimen #1 is received fresh, subsequently placed in formalin labeled left axillary content and consists of a 10 x 8.5 x 3 cm  aggregate of adipose tissue which is palpated to reveal multiple indurated lymph nodes ranging from 0.3 cm to 3.7 cm in greatest  dimension. A representative section of each node is submitted as follows: 1A-1B-  each cassette containing a representative section of each of four grossly positive nodes. 1C- four halves of grossly four positive nodes 1D-1E-  each cassette containing half of two grossly positive nodes 1F- three representative sections of three grossly positive nodes. 1G- four representative sections of four grossly positive nodes. Additional sections are submitted as follows:. 1H-  remaining node corresponding to negative node in slide 1B. 11-  remaining nodes corresponding to fibrotatty tissue in slide 1A. Specimen #2 is received in formalin labeled left breast cancer at 2 o'clock (suture marks anterior) and consists of an oriented portion of fibrofatty tissue measuring 10 cm from medial to lateral, 7 cm from superior to inferior and 2.7 cm from anterior to posterior. Loosely received outside ot the tissue is a localization wire. The specimen is radiographed to document the loose Iocalization wire, a mass and a clip. The tissue is inked per protocol such that the superior is blue, the anterior is green, the medial is red, the lateral is yellow, the anterior is orange, and the posterior is black. The specimen is serially sectioned from lateral to medial into 9 slices to reveal a 2.4 x 2.3 x 2.2 cm indurated gray-white stellate mass in slices #4-8, grossly coming to within 0.5 cm of the posterior and superior margin, information relayed to the surgeon intraoperatively. The remaining cut surfaces are made up of approximately 10% dense tibrous tissue. Note the tissue is triaged per  protocol. Representative sections, concentrating on the closest margins, are. submitted as follows: 2A-2B-  representative perpendicular sections with lateral margin 2C- middle tibrous tissue from slice #2 2D- middle tibrous tissue from slice #3 2E- posterior margin with tumor slice #4 2F- superior posterior margin from slice #4. 2G- anterior margin with tumor slice #5 2H- anterior inferior margin slice #5 21-  superior posterior margin with tumor slice #5. 2J-2K- bisected section of posterior superior margin with tumor slice #6 2L- anterior inferior margin with tumor slice #6 2M- interior margin with tumor slice #7 2N- posterior margin with tumor slice #7 20-  superior margin with tumor slice #7 2P-2R-  representative medial margin. Additional sections are submitted as follows:. 2S-2T- tumor slice 8, no real margins, ink run over.  2U-2BB-remaining superior half of medial margin (true margin over-inked red Page 2 of 3
+
+--- Page 3 ---
+Surgical Pathology Report TIF: approximately  Specimen #3 is received fresh for orientation labeled left breast true deep margin and consists of an oriented portion of fibrofatty tissue measuring 6 x 5 cm from medial to lateral, 3.5 cxm from superior to inferior and 0.4 cm from anterior to posterior. The true  margin is inked per protocol such that the center is black, the superior edge is blue, the inferior edge is green, lateral edge yellow  and the medial edge is red. The specimen is serially sectioned from medial to lateral into 12 slices to reveal focally dense fibrosis. No tumor is palpated or grossly identified. The specimen is submitted entirely labeled 3A-3K at approximately. Intraoperative Consult Diagnosis 2A 2.4CM GROSS TUMOR WITH NEGATIVE MARGINS, POSTERIOR CLOSEST. Amendments Amended: Reason: Proofreading error Previous Signout Date: Primary Tumor Site Dis is (cacle): QUALIFIE ISQUALIFIE Page 3 ot 3 END OF REPORT
\ No newline at end of file
diff --git a/output/text/3a74215a-7e25-4cb7-bb2a-f33273094d31.txt b/output/text/3a74215a-7e25-4cb7-bb2a-f33273094d31.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8f100cc96b9bc6e61cfbca4af13a3857faa56bf3
--- /dev/null
+++ b/output/text/3a74215a-7e25-4cb7-bb2a-f33273094d31.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+SURGICALPATHOLOGY SPECIMEN A. KIDNEY - Left renal mass - margins - ? cancer CLINICAL INFORMATION Left kidney tumor GrOss DEscriptIOn -imen is received fresh for frozen section diagnosis labeled with the patient's name. Ieft renal mass" and consists of a 6.5 x 5.5 x 5 cm red-brown portion of partial nepnrector. urrace of the kidney overlying the tumor is inked in green. The entire normal kidney margin is inked in black. The estimated tumor size is 3 x 2 x 2 cm. The cut surface is not homogeneous with areas of dark brown tumor admixed with foci of lighter tan friable tumor. Representative sections are frozen as FSA1 and FSA2. The remainder of tissue. are submitted in cassettes (A1) and (A2). respectively. Representative sections submitted in cassette (A3)-(A9). SLIDE KEY: A1 -- remainder of tissue from FSA1. A2 - remainder of tissue from FSA2. A3-A6 -- sections with tumor A7 -- normal-appearing kidney A8-A9 -- additional sections of margins near tumor.. FROZEN SECTION DIAGNOSIS: Renal mass, left: "Deep and renal capsule margins within a few microns. Renal carcinoma, classification pending permanent section." MICROSCOPIC DESCRIPTION Permanent sections show a variant of papillary renal cell carcinoma with areas of solid proliferation without papillary structures. The lesion has a pseudocapsule, and it appears to be resected with approximately 0.4 mm distance between the tumor and the normal kidney resection plane. The papillary appearance is more pronounced at the periphery of the tumor. Nuclei are bland and are consistent with Fuhrman grade 1 without evidence of nucleoli. The cells in the solid areas have some kind of an eosinophilic matrix with occasional globoid bodies. Mitotic figures are rare, and in some areas, there is
+
+--- Page 2 ---
+the appearance of pseudorosette formation. The lesion contains some calcium. In slide A-6, there are good psammoma bodies represented. The nearby renal parenchyma appears to be normal. Vascular or Iymphatic invasion is not observed. IMMUNOHISTOCHEMICAL STUDIES: These are carried out to evaluate the solid areas of the tumor. The controls are appropriate, and the. following results are obtained: Synaptophysin -- negative. Chromogranin - negative. Keratin cocktail -- there is 1-2+ reactivity. CK7 - there is 1+ staining of the cytoplasm. Vimentin - there is good vimentin staining, about 2-3+. CD10 -- negative. COMMENT: We are dealing with an unusual variant of papillary renal cell carcinoma with solid areas and presence of. Iow-grade nuclei indicating that this would fit a type 1 papillary carcinoma which is associated with a better survival rate than classic clear renal cell carcinomas. The lesion appears to be resected although it is close to the resection plane, at least focally. as reviewed the slide and concurs. A neuroendocrine component has been excluded. Surgical Pathology Cancer Case Summary, Kidney, Partial Nephrectomy SPECIMEN TYPE: Left partial nephrectomy. TUmOR SITE: Left kidney. TUMOR SIZE: 3 x 2 x 2 cm. MICROSCOPIC EXTENT OF TUMOR: Limited to the kidney. HISTOLOGIC TYPE: Variant of papillary renal cell carcinoma with solid areas. HISTOLOGIC GRADE: Grade 1, nuclei uniform and round with inconspicuous nucleoli. EXTENT OF INVASION: T1, tumor less than 7 cm. MARGINS: Uninvolved. BLOOD/LYMPHATIC INVASiON: Absent. ADRENAL GLANDS: Not applicable. REGIONAL LYMPH NODES: NX. DISTANT METASTASIS: MX. ADDITIONAL PATHOLOGIC FiNDINGS: Presence of CK7 reactivity and negative CD10. Solid form of panillary renal cell carcinoma. Normal renal parenchyma adjacent to tumor. FINAL DIAGNOSIS LEFT KIDNEY, PARTIAL NEPHRECTOMY - 3-cm papillary renal cell carcinoma, solid variant. - Nuclear grade 1.. - Type 1 papillary renal cell carcinoma. - Margins free of tumor..
+
+--- Page 3 ---
+CPT CODES: 88331x1,88332x1, 88307x1, 88342x6
\ No newline at end of file
diff --git a/output/text/3a8770a0-2ec0-455e-acda-0a6c3ef800ef.txt b/output/text/3a8770a0-2ec0-455e-acda-0a6c3ef800ef.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f5d0e132b5b21a98b2e58571404a238e774904f2
--- /dev/null
+++ b/output/text/3a8770a0-2ec0-455e-acda-0a6c3ef800ef.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TCGA-D5-6529 page 1 / 1 Examination: Histopathological examination. Material: Multiple organ resection -- segment of the large intestine. Physician in charge: Material collected on: Material received on: Expected time of examination: Clinical diagnosis: Examination performed on Macroscopic description: 17 cm length of the large intestine with mesentery sized 16 x 6 x 3cm, a 7 cm segment of the small intestine and a 6.7 cm appendix. Ulcerous tumour found in the mucosa, sized 4.7 x 4 x 1,2 cm. The lesion placed 7.0 cm from the proximal cut end, 12.0 cm from the distal cut end, and 0 cm from the Baughin valve. Minimum side  margin is 5.0 cm.. Microscopic description: Adenocarcinoma tubuloapapillare (G1). Infiltratio carcinomatosa tunicae muscularis propriae et telae adiposae pericolicae. Minimum side margin is 5 cm. Incision lines free of neoplastic lesions. Lymphonodulitis reactiva lymphonodorum (No Xix). Histopathological diagnosis: Adenocarcinoma tubulopapillare coli (G1; Dukes B, Astler-Coller B2; pT3; pN0).. CONTACT YOUR DOCTOR WITH THIS REPORT!
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diff --git a/output/text/3b10abd0-6b10-43e3-b516-f3882bbc5b59.txt b/output/text/3b10abd0-6b10-43e3-b516-f3882bbc5b59.txt
new file mode 100644
index 0000000000000000000000000000000000000000..04255806688d489ebf2f83f0aae827c8368fe3b8
--- /dev/null
+++ b/output/text/3b10abd0-6b10-43e3-b516-f3882bbc5b59.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis: Colon resection material includes a moderately differentiated adenocarcinoma of the colorectal type, measuring a maximum of 2.5 cm, with infiltration of the pericolic fatty tissue with two. regional lymph node metastases. Tumor-free colon resection margins. Tumor stage: pT3 pN1 (2/13) pM1 (clinically liver metastases); G2, L1, V0, clinically R2
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diff --git a/output/text/3b157f2d-76d6-46f1-9936-f919418c47ca.txt b/output/text/3b157f2d-76d6-46f1-9936-f919418c47ca.txt
new file mode 100644
index 0000000000000000000000000000000000000000..49529f2baa259979cf2562b4d618f800c433487c
--- /dev/null
+++ b/output/text/3b157f2d-76d6-46f1-9936-f919418c47ca.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:03BD8920-CA01-4818-BBD7-925DDD3F6908 TCGA-AN-A0FW-01A-PR Redacted TSS Patient ID: Case #: DOB: Sex: Female Ethnicity (Race): Cancer Sample Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma Date of Procurement: Anatomic Site: Left Breast Tumor location: Primary Tissue Specification: Tumor Specimen Matrix: Tissue Specimen Format: Frozen Container: cryomold Type of Procurement: Radical mastectomy Grade: 2 T Stage: 2 N Stage: 1 M Stage: 0 Treatinent: none Treatment Details: n/a  Normal Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw Matrix: Blood Specimen Format: frozen Container: tube Date of Procurement Ics-0-3 Carcinunr, mnfiltratig duct, nos 8socf3 Sife: breut no; C5o.q 74/2r/rt
\ No newline at end of file
diff --git a/output/text/3b27391a-7bf5-4b72-aadc-7b70f779f989.txt b/output/text/3b27391a-7bf5-4b72-aadc-7b70f779f989.txt
new file mode 100644
index 0000000000000000000000000000000000000000..bb9626d223d9dab2d5480aad9eb68caf6c019559
--- /dev/null
+++ b/output/text/3b27391a-7bf5-4b72-aadc-7b70f779f989.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+/cD-0-3 Carcnoma,mfit+naHrg cucthl, N0s 85oof3 Sife: B/uot Nos C509 1/a|n Mw Diagnosis: Poorly differentiated invasive ductal carcinoma (tumor diameter: 4 cm) Concluding tumor classification for the left breast: NOS, G III, pT2N1aL0v0R0 UUID:FC0C1BF3-74C3-4DFC-B985-2FD1728E287A TCGA-A8-A08R-01A-PR Redacted
\ No newline at end of file
diff --git a/output/text/3b399b5c-1ac8-46a9-860c-569f8bfae97a.txt b/output/text/3b399b5c-1ac8-46a9-860c-569f8bfae97a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6c3783bc44c83f32062f571df1847a88e37890c9
--- /dev/null
+++ b/output/text/3b399b5c-1ac8-46a9-860c-569f8bfae97a.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+DIAGNOSIS: Kidney, right, partial nephrectomy: 1. Renal cell carcinoma with papillary features, suggestive of papillary Type i.. Capsule is free of tumor. Chronic interstitial nephritis, occasional incipient lesion present 2. Adipose tissue, over tumor, excision: Cluster of tumor cells and fat, see Note. 3. Gallbladder, cholecystectomy: Chronic cholecystitis. NOtE: The group of tumor cells present in the fat appears to be floaters or contamination. Staining for CK7 is strongly positive. RENAL PELVIS: Resection/Nephroureterectomy, Partial Procedure Nephrectomy, partial Specimen Laterality Right Tumor Size Greatest dimension: 4.3 cm Additional dimensions: 2.2 cm Histologic Type Suggestive of papillary carcinoma, type ! Patient Identification
+
+--- Page 2 ---
+Associated Epithelial Lesions Occasional Tumor Configuration. Papillary Margins Adipose tissue, perirenal Margin(s) involved by invasive carcinoma Lymph-Vascular Invasion Not identified CLINICAL INFORMATION: Allocate Order to Brief Clinical History:. with incidentally found R renal mass, hemangioma on liver. cholecystitis Specimen Taken For Protocol: PROcEDuRE: Pre-Operative Diagnosis: Right renal mass Post-Operative Diagnosis:. same Operative Findings: as dictated SPECIMENS SUBMITTED: 1. KIDNEY WEDGE EXCISION, RIGHT, Renal 2. FAT, Over tumor 3. GALLBLADDER GROSS DESCRIPTION: Received fresh with patient's name, medical record number, and further specified. as: 1. "Renal mass deep margin ink" is a red-tan soft tissue mass with one surface inked in black measuring 5.2 x 3.4 x 3 cm. The remainder of specimen is inked in green in the frozen section room. The specimen is cut to reveal a tan solid tumor measruing 4.3 x 2.2 cm with a central area of hemorrhage and necrosis. There is a rim of normal renal parenchyma on one side measuring up to 0.6 cm. Approximately 0.6 x 0.6 Lab on by  in the  the specimen matches the above description. The tumor can be grossly noted and it appears to be at the previously inked blue margin. Representative sections are submitted in white cassettes labeled. 1A-1H as follows: 1A-1C - tumor and closest resection margin inked in blue; 1D-1G -- tumor and papillary aspect; 1H -- normal renal parenchyma. Patient Identification
+
+--- Page 3 ---
+2.  "Fat over tumor, outer margin". It consists of multiple yellow fibroadipose tissue measuring in aggregate 4.2 x 3.5 x 0.6 cm. A smaller tan piece measuring 1.3 x 0.5 x 0.4 cm presenting small papillae can be grossly noted. The specimen is serially sectioned revealing a small area of hemorrhage and a similar papillary tan structure. The specimen is entirely submitted in white cassette labeled 2A-2F. 3. "Gallbladder".It consists of a 9.8 x 3.6 x 2.8-cm gallbladder specimen.The serosal surface is unremarkable. The specimen is open to reveal a red-tan mucosa surface and approximately 10 ml of green/brown bile. No gallstones are identified. Approximately 1 x 1 x 0.2 cm of tissue is procured for Lab and 1 x 1 x 0.2 cm for the The procurement was performed by on 03/01/10 at 2:15 p.m.In the the specimen matches the above description. The mucosa appears green and velvety with a maximum thickness of O.5 cm. The bile duct is probed. It measures 0.3 cm in maximal diameter. Representative sections are submitted in 2 white cassettes labeled 3A and 3B (3A - bile duct and vascular margin; 3B - representative section of gallbladder). Gross description dictated by No consultants Patient Identification.
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diff --git a/output/text/3b779807-81b6-4858-9e18-c58c13dc7daf.txt b/output/text/3b779807-81b6-4858-9e18-c58c13dc7daf.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5ef2fea64b17356d87cb60d7742f76253cfc9310
--- /dev/null
+++ b/output/text/3b779807-81b6-4858-9e18-c58c13dc7daf.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TCGA # Internal Sample ID: Diagnosis: The material presented is a left hemicolectomy specimen with a moderately differentiated,  invasive adenocarcinoma of the colon, G 2, of the type of a mucous carcinoma, with permeation of all wall layers (p T 3), free resection margins, free lymph nodes (p N 0) and an additional tubular adenoma in the mucosal region. Comment: Other diverticulum formations were also detectable over the course of the intestine. 1cs-0-3 814013 adenocrcioma, Nos UUID:48C27265-38FC-4291-8CB8-B10F577B2FEB Redacted
\ No newline at end of file
diff --git a/output/text/3ba1a9cb-fc43-4422-8038-a47f3069b098.txt b/output/text/3ba1a9cb-fc43-4422-8038-a47f3069b098.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6e9f93f8b27899614debc1ae4ac6211d1d1a6df3
--- /dev/null
+++ b/output/text/3ba1a9cb-fc43-4422-8038-a47f3069b098.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+page 1 / 1 Department of Cancer Pathology Examination: Histopathological examination. Internal invoice No. Cost of diagnostic procedure Examination No.:. Patient: xxx PESEL: XXX Age: Gender: F /cs-0-3 Materiai: Multiple organ resection -- left breast and axillary tissue. Unit in charge: CaCir unu nJi{fnsmy 1obwley N1s 855ef3  Physician in charge. Siter brsst,nos C50.9 Material collected on: : Material received on: 1 Expected time of examination: up to 8 working days. Clinical diagnosis: Cancer of the left breast. Status following mammotome biopsy. Examination performed on Macroscopic description: Left breast sized 22 x 18 x 6 cm removed with axillary tissue of 7 x 5 x 3 cm and a skin flap of 15 x 7 cm.. Tumour sized 2.2 x 1.5 x 1.3 cm found in the outer lower quadrant; placed 1.5 cm from the lower boundary, 2 cm from the base; and 1.5 cm from the skin. Lymph nodes ofup to 1.5 cm in length. Microscopic description: Carcinoma lobulare invasivum NHG 2 (3+2+1/ 0 mitoses /10 HPF, visual area of 0.55mm). Infiltratio carcinoma mamillae. Lesion in situ of the type carcinoma lobulare (Lcis) - pagetoid spred.. Glandular tissue showing parenchyma atrophy Axillary lymph nodes:  Metastases carcinomatosae in lymphonodo (No I / x) Histopathological diagnosis: Carcinoma lobulare invasivum et lobulare in situ mammae sinistrae. Invasive lobular carcinoma and carcinoma in situ of the left breast Metastases carcinomatosae in lymphonodo axillae (No I / x). Cancer metastases in axillary lymph nodes.. (NHG2, pT2, pN1a) Compliance validated by: Examination performed on: Results of immunohistochemical examination: Expression of Ki 67 proliferation antigen found in 5% of cell nuclei. E-cadherin -- negative reaction on neoplastic cells. Ck7+ Compliance validated by: CONTACT YOUR DOCTOR WITH THIS REPORT!E UUID:9AAB53EC-89A0-4878-BB9D-D96BC56B54C4 TCGA-D8-A1XO-01A-PR Redacted
\ No newline at end of file
diff --git a/output/text/3bdb850c-baf3-4e42-a2b2-79528f7f21af.txt b/output/text/3bdb850c-baf3-4e42-a2b2-79528f7f21af.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4f99013424046bb1961f65161dd226f0c5ca40c4
--- /dev/null
+++ b/output/text/3bdb850c-baf3-4e42-a2b2-79528f7f21af.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+TCGA-A6-2686 SPECIMEN Right colon CLINICAL NOTES PRE-OP DIAGNOSIS: Right colon CA CLINICAL HISTORY: with above - + on bx GROSS DESCRIPTION Received fresh in a container labeled "right colon" is a previously opened portion of bowel, with a tan-pink smooth. glistening serosal surface, and with adherent yellow adipose tissue. There is an appendix present 4.5 cm long x 0.6 cm. in diameter. The appendix is grossly unremarkable, with a tan serosa, tan wall and tan mucosa, without focal lesion. The bowel consists of 5 cm. of distal small bowel and 15 cm. of contiguous proximal colon. There is a circumferential 6 x 4.5 x 1.2 cm. tumor mass in the ileocecal valve/cecal region. It grossly extends through the full thickness of the bowel wall and into surrounding adipose tissue. There is possible serosal umbilication, with this area inked blue, with this area difficult to assess due to the prior opening. The tumor is not near the radial margin. The mucosa away from the mass lesion is tan-pink and glistening with a normal pattern of folds. The colonic portion of the specimen averages 8 cm. in circumference, and the small bowel segment averages 4.2 cm. in circumference..  The small bowel is without focal lesion. The adipose tissue is dissected, and multiple soft tan lymph nodes are identified. Rs-13, following fixation, according to the accompanying block summary.. BLOcK suMMARy: 1 - proximal and distal resection margins; 2-5 tumor, including relationship to uninvolved bowel and to serosal surface; 6 - appendix, 7 - largest lymph node, bisected, 8-13 lymph nodes, with multiple lymph nodes per block.
+
+--- Page 2 ---
+MICROSCOPIC DESCRIPTION The following template summarizes the findings in this case: Histologic type: Adenocarcinoma Histologic grade: Poorly differentiated. Primary tumor (pT): pT3. Carcinoma invades through the full thickness of the bowel wall and into surrounding adipose tissue. Proximal margin: Negative. Distal margin: Negative Circumferential (radial) margin: Negative Distance of tumor from closest margin: See gross description. Vascular invasion: Not definitively identified. Regional 1ymph nodes (pN): pN0.  Thirty-three lymph nodes are. identified, and they are negative for malignancy.. Non-lymph node pericolonic tumor:  Not identified Distant metastasis (pM): pMX Other findings: The appendix is without specific diagnostic abnormalities. DIAGNOSIS Terminal ileum, appendix, and right colon, excision. - Poorly differentiated adenocarcinoma, invading through the full thickness of the bowel wall and into surrounding adipose tissue (see microscopic description). Margins negative for malignancy..  Thirty-three lymph nodes negative for malignancy.. - Appendix without specific diagnostic abnormalities..
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diff --git a/output/text/3bf22160-e9c7-4fa3-aefb-f3f1ac58b0fa.txt b/output/text/3bf22160-e9c7-4fa3-aefb-f3f1ac58b0fa.txt
new file mode 100644
index 0000000000000000000000000000000000000000..03f0fd40908c9c693ab830ee950e010b4fd71a94
--- /dev/null
+++ b/output/text/3bf22160-e9c7-4fa3-aefb-f3f1ac58b0fa.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:508CD8F7-03FB-4141-888D-7B00DAB8B206 Redacted TDb-3 Research Gross Description. 8Q4d|3 Ceol 5rL D %idney NoS Cb4.9 Research Dx Left partial nephrectomy: S u/22/3 Papillary renal cell carcinoma, type 1. CASE SUMMARY FOR NEPHRECTOMY FOR RENAL CELL CARCINOMA: Procedure: Partial nephrectomy. Specimen laterality: Left Tumor site: Upper pole (posterior) Tumor size: 2.4 cm in greatest dimension Extent of disease: Tumor limited to kidney Histologic type: Papillary renal cell carcinoma, type 1. Sarcomatoid features: Not identified Tumor necrosis: Not identified. Histologic grade (Fuhrman Nuclear Grade): Not applicable. Margins: Focally extends to the cauterized inked parenchymal resection margin of the specimen Lymphovascular invasion: Not identified Pathologic staging (pTNM): Primary tumor: pT1a: Tumor 4 cm less in greatest dimension, limited to the kidney Regional lymph nodes: pNX: Cannot be assessed Pathologic findings in nonneoplastic kidney: Chronic inflammation, congestion and dystrophic calcifications. Other tumors and/or tumor-like lesions: None identified. AJCC Staging (7th edition) pT1a pNX pM not applicable Research QC Tumor: 95% tumor nuclei 0% necrosis 5% normal Normal: na Research Specimen Specimen Process Time Blood draw time: Plasma frozen time: Serum frozen time: Buffy coat frozen time:. Warm ischemia start time Cold ischemia start time: Formalin fixation start time: Total cold ischemia time Formalin fixation stopped time:. Total formalin fixation time:
+
+--- Page 2 ---
+Specimen Weight Tumor 1-69 mg, 2-102 mg Specimen Size Plasma x 3 Serum x 2 Buffy coat x 1 Cryovials x 2 Tumor x 2 FFPE x 2 Tumor x 2 Study Patient Consent Yes
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diff --git a/output/text/3c4b570d-b920-44e7-811b-15762aa21d00.txt b/output/text/3c4b570d-b920-44e7-811b-15762aa21d00.txt
new file mode 100644
index 0000000000000000000000000000000000000000..cc8500a4d451329eb995a1104d00d4a326efd841
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Page 1 of 3 Result Type: Surgical Pathology Report. Result Date: Encounter 7CD-0 3 info: J 8Q6of3 D$3o ney NsS Sit. C64.9 Surgical Pathology Report OOId/4/l3 *Final* UUID:45764545-C185-4BD5-AA49-0EB0E993984D TCGA-SX-A7SN-01A-PR Redacted Surgical Pathology Report. Name: Requested By: DIAGNOSIS: A. Gallbladder, cholecystectomy: Mild chronic cholecystitis. No calculi identified. B. Left renal mass, partial nephrectomy:. Procedure/laterality: Left partial nephrectomy. Histologic type: Papillary renal cell carcinoma. Nuclear grade (Fuhrman, 1-4): 2/4. Tumor size: 4.2 x 3.8 x 3 cm. Tumor site: Clinically lower pole. Tumor focality: Unifocal.. Sarcomatoid features: Not identified.. Tumor necrosis: Not identified. Microscopic tumor extension: Extension into perinephric tissue: Not identified. Extension beyond Gerota's fascia: Not identified. Extension into renal sinus: Not included with the specimen.. Extension into renal vein: Not applicable. Extension into collecting system: Not identified. Extension into adrenal gland (if applicable): Not applicable. Surgical margins: Negative for carcinoma.. Lymph-vascular invasion: Not identified.. Lymph nodes: Not applicable. Pathologic findings in nonneoplastic kidney: Only minute benign kidney tissue present with no significant pathologic changes. Pathologic staging: pTlb.. Biorepository sample (if applicable): Block B7 contains more than 90% tumor cell nuclei. Block(s) containing malignancy suitable for additional testing: B1-7 C. Umbilical hernia sac, excision: Membranous fragment of fibroadipose tissue with mild chronic. inflammation with scarring, compatible with hernia sac.. CLINICAL INFORMATION:
+
+--- Page 2 ---
+Page.2 of 3 Left renal mass. SPECIMEN (S) : A:Gallbladder B:Left renal mass C:Umbilical hernia sac GROSS DESCRIPTION: Performed by A. Received fresh labeled and "gallbladder," is a previously opened gallbladder, 9 x 3 cm. The serosa is glistening and smooth.  The wall is uniformly 0.3 cm in thickness and the mucosa velvety soft and pale green. No calculi are received. Sampled in one cassette labeled B. Received fresh labeled and "left renal mass". Partial nephrectomy. Procedure: Specimen laterality: Left. Low pole clinically. Tumor site: Tumor size: 4.2 x 3.8 x 3 cm. Tumor focality: Unifocal. Gross extent of tumor: Extension into perinephric tissue: Not identified. Extension beyond Gerota's fascia: Not identified. Extension into renal sinus: Renal sinus tissue not included with specimen. Extension into renal vein: Cannot evaluate with the specimen. Extension into collecting system: Not identified. Adrenal gland: Not present. Gross notes: Gross tumor characteristics: Mottled red-tan and gray, soft, friable. Kidney weight: 40 g. The specimen has overall dimensions of 5 x Kidney dimensions: 3.5 x 3.5 cm including attached fat.. Distance to margin: 0.1 cm or less in multiple areas, grossly. Lymph nodes: None identified.. Parenchymal margin inked black, overlying fatty Inking details: soft tissue margin inked blue.. Biorepository sample submitted: Yes.. Block key for specimen B: B1) Tumor and overlying inked fatty margin; B2-B4) tumor and parenchymal margin; B5-b6) additional tumor samples; B7) mirror image of biorepository sample, IRE' C. Received fresh labeled and "umbilical hernia sac," is a rubbery pink and tan-gray portion of fibrofatty tissue, 2.7 x 1.2 x 0.8 cm. Sampled in one cassette labeled Support for the diagnosis in this case may have included the use of immunohistochemistry tests that were developed and whose performance characteristics were determined by  They have not been cleared or approved by the U.s. Food and Drug Administration (FdA). The FDA has determined that such clearance or approval is not
+
+--- Page 3 ---
+Page 3 of 3 necessary. These tests should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 ('cLIA') as qualified to perform high complexity clinical laboratory testing. 8/4/
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diff --git a/output/text/3c528c47-1651-4120-9e22-dccb159efe86.txt b/output/text/3c528c47-1651-4120-9e22-dccb159efe86.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4d2f647c8dd9f7238d2b36f301e2c68e6429b727
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:5FF5CE63-2A8F-4117-A384-A57EED647308 TCGA-LD-A66U-01A-PR Redacted IcDO-3 85a63 Sit &BuotN83 Surgica! Pathology Report 250.9 * Amended * YI s/o{13 DATE OBTAINED: LOCATION: DATE RECEIVED: SUBMITTING MD: MD DATE REpORTED: CC: DIAGNOSIS 1. SupERfICIaL RIghT AXILLAry bREaSt TISSuE, EXCISION: SmALL fOCUS Of INVaSiVe LOBULAR CARCiNOMA (0.6mm) PRESENT AT ThE EDgE OF ONe fRAGmENT, WITH SUrrOUNDING ADiPOSE TISSUE; RARE bENIGN BREAST ACINI; SEE COMmENT 2. RIGHT AXiLLARY SENTINEL LYMPH NODE #1: ONE LYMPH NODE POSITIVE FOR MICROMETASTASIS (0.6 mm); SEE COmmEnT. 3. RIGhT AXILLARY SENTiNEL LymPH NODE #2: ONE LYMPh nODE POSITIVE FOR MULTiPLE fOCi OF MICROMETASTASIS (LARGEST 1.5MM), CONFIRMED BY CYTOKERATIN STAIN; NO EXTRANODAL EXTENSION. 4. RIGHT BREAST, mASTECTOmy: INVASIVE LOBULAR CARCINOMA SIZE (INVASIVE): 3.5 cm LATERALITY: Right TUMOR FOCALITY: Unifocal LESIONAL SITE: 10:00 HISTOLOgIC TypE: Invasive lobular carcinoma, classical and pleomorphic types NUCLEAR GRADE: 11 and III of III HISTOLOgIC GRADE: N/A (invasive lobular carcinoma) IN-SITU COMpONenT: LCIS (Classical and focal pleomorphic types; NG II, focal III) LyMPH NODE SAMPLiNG: Positive (2/15), largest 3mm; no extranodal involvement; see specimens #2, #3 & #6 AJCC CATEGORIES: Stage IIB pTNM: pT2 pN1mi cTnm: cT2 cN1 cMO INTEGRITY/ORIENTATION:S Intact specimen with designated margins.  MARGINS (invasive lobular): Focal positive superior/anterior margin (see final margin in #1); Other margins negative (>3mm) LYMPHOVASCULAR INVASION:E Present MICROCALCIFICATIONS: Not identified NIPPLE/SKIN: Negative skin and nipple SKELETAl mUSCLE: Present, focal, negative for tumor OTHER: Focal sclerosing adenosis, columnar cell changes and usual mild hyperplasia 5. Left breaSt, prOphylActic mastectOmy: benign Breast wIth Small papilLOmatOSiS, SCLEROSING ADENOSIS AND MILD USUAL DUCTAL HYPERPLASIA; NO ATYPIA; NEGATIVE SKIN AND NIPPLE. 6. RighT AXILLARY CONTeNTS, DISSECTiON: THIRTEEN NEgATIVe Lymph NODeS (0/13).  4{913 Page 1 of 3 1873
+
+--- Page 2 ---
+Surgical Pathology Report ***Electronically Signed Out*** COMMENT #1: There is one small focus of invasive carcinoma at the edge of a fragment (0.6mm, confirmed by negative calponin and p63 immunostain), with severe cautery artefact, which was not seen on frozen section. The tumor is surrounded by fatty tissue, and thus would be regarded as negative final margin for specimen #4. #2: There is single focus of micrometastasis in the SLN #1. This focus is only present in slide 2B CTD2, and not on other levels, frozen smears and cytokeratin immunostained slides. 88307x5, 88305, 88331, 88332, 88333x2, 88342x3 Clinical Diagnosis and History: Right breast cancer 10 o'clock cT2,cNI,cMo, clinical stage 2B Tissue(s) Submitted: 1: SUPERFICIAL RIGHT AXILLARY BREAST TISSUE 2: RIGHT AXILLARY SENTINEL LYMPH NODE #1 3: RIGHT AXILLARY SENTINEL LYMPH NODE #2 4: RIGHT BREAST LONG STITCH LATERAL SHORT STITCH SUPERIORE 5: LEFT BREAST LONG STITCH LATERAL SHORT STITCH SUPERIOR 6: RIGHT AXILLARY CONTENTS Gross Description: Specimen #1 is received fresh for intraoperative consultation, labeled with the patient's name and superficial right axillary breast tissue, and consists of a 2.7 x 1.7 x 0.6 cm tan-yellow lobulated adipose tissue which is entirely submitted for frozen section analysis labeled 1AFS-1BFS. Specimen #2 is received fresh for intraoperative consultation, labeled with the patient's name and right axillary sentinal lymph node #1, and consists of a single tan-pink, nodular tissue consistent with lymph node measuring 1.3 x 0.7 x 0.5 cm. The specimen is serially sectioned and two intraoperative smears are performed. The specimen is entirely submitted labeled 2A-2B. Specimen #3 is received fresh on a blue surgical towel for intraoperative consultation, labeled with the patient's name and right axillary sentinal lymph node #2, and consists of a singie tan-pink, nodular tissue consistent with lymph node measuring 1.0 x 0.5 x 0.5 cm. The specimen is serially sectioned and an intraoperative smear is prepared. The specimen is entirely submitted labeled 3A-3B. Specimen #4 is received fresh for formalin, labeled with the patient's name and right breast, long stitch lateral, short stitch superior, and consists of a 520 gram, 18 (superior to inferior) by 17 (medial to lateral) by 4 (anterior to posterior) cm right mastectomy specimen. A short suture designating superior, and a long suture designating lateral are present. A 14 x 4.5 x 0.3 cm white-tan, unremarkable ellipse of skin is identified containing a 1.3 x 1.1 x 0.3 cm unremarkable, everted nipple. The areola measures 3.5 x 2.5 cm. The specimen is differentially inked as follows: superior/anterior -- blue, inferior/anterior -- green, posterior/deep -- black and serially sectioned from lateral to medial to reveal a 3.5 x 2.5 x 1.1 cm firm, tan-pink, irregular mass at the 10 o'clock position. This mass is focally 0.2 cm from the posterior, 0.2 cm from the superior/anterior, and greater than 4 cm from the inferior margins. The mass is present in multiple sections and is seen to extend more centrally. No other lesions are grossly identified. The surrounding breast parenchyma consists of white, fibrous tissue (60%) and tan lobular adipose tissue (40%). Time in formalin: 14:20. Representative sections are submitted as follows: 4A-4B:  Mass closest to superior/anterior and deep margins, contiguous section 4C: Mass to deep margin 4D: Mass to superior/anterior margin. 4E: Mass to deep margin 4F-4G: Tumor without margin 4H: Mass to deep. 41: Tumor without margin 4J: Inferior margin closest to tumor 4K-4L: Fibrous tissue immediately medial to mass. 4m: Fibrous tissue in central breast 4N: Fibrous tissue in medial most breast. Page 2 of 3
+
+--- Page 3 ---
+Surgical Pathology Report 40: Nipple and skin section closest to mass. 4p: Outer upper quadrant 4Q: Outer lower quadrant 4R:  Inner upper quadrant 4S: Inner lower quadrant Specimen #5 is received fresh for formalin, labeled with the patient's name and left breast, long stitch lateral, short stitch superior, and consists of a 550-gram, 20 (superior to inferior) by 15.9 (medial to lateral) by 5.4 (anterior to posterior) product of left mastectomy. An unremarkable, tan ellipse of skin is identified measuring 13.3 x 4.2 x 0.2 cm. The everted nipple measures 1 x 0.9 cm and resides within a 4 x 2.9 cm areola. The specimen is differentially inked as follows: superior/anterior -- blue, inferior/anterior -- green, posterior/deep -- black and serially sectioned from medial to lateral to reveal no distinct mass but areas consistent with fibrocystic changes containing blue domed cysts averaging 0.3 cm in greatest dimension. The surrounding breast parenchyma consists of tan-yellow lobulated adipose tissue (60%) and white, fibrous areas (40%). No other lesions are grossly identified. Time in formalin:. Representative sections are submitted as follows: 5A: Nipple 5B: Outer upper quadrant 5C: Inner upper quadrant 5D: Inner lower quadrant 5E: Outer lower quadrant 5F-5L: Fibrous areas 5M: Superior margin to fibrous area. 5N: Deep margin to fibrous area. 50: Inferior margin to fibrous area. Specimen #6 is received fresh on a blue surgical towel, labeled with the patient's name and right axillary contents, and consists of multiple tan-pink, nodular tissues consistent with lymph nodes ranging from 0.5 to 2 cm in greatest dimension. All grossly identifiable lymph nodes are submitted as follows: 6A-B:  One lymph node, bisected, each cassette. 6C-6D: One lymph node, bisected 6E-F: One lymph node, bisected, each cassette. 6G-H: Intact lymph nodes Intraoperative Consult Diagnosis 1A-1B/FSDX: BENIGN BREAST TISSUE AND FAT; NO MALiGNANCY. 2A/GDX/SMDX: NEGATIVE LYMPH NODE (0/1) 3A/GDX/SMDX: POSITIVE LYMPH NODE (1/1). Amendments Amended:  Reason: Further review of case. SLN #2 should be counted as multiple micromet Previous Signout Date: Page 3 of 3 END OF REPORT
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diff --git a/output/text/3c59993c-6b6f-4fd6-8b60-6abeba058d16.txt b/output/text/3c59993c-6b6f-4fd6-8b60-6abeba058d16.txt
new file mode 100644
index 0000000000000000000000000000000000000000..72256a411e75f22f296fed657512c160a6e23a22
--- /dev/null
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+
+--- Page 1 ---
+Page 1 of 3 Result vate: Performed By: Encounter UUID:2176416F-1584-454C-92C6-CA520C40E902 TCGA-SX-A7SS-01A-PR Redacted IcD-O -3 Carenonio, feepib lory neral cell 8Qb0|3 Sute RKudney 1g8 064.9 Surgical Pathology Report fO101413 *Final* Surgical Pathology Report Name: DIAGNOSIS: A. Precaval lymph node: One lymph node, negative for malignancy (0/1). B. Right renal mass, partial nephrectomy: Papillary renal cell below). Procedure/laterality: Partial nephrectomy, right.. Histologic type: Papillary renal cell carcinoma, type 2. Nuclear grade (Fuhrman, 1-4): 3. Tumor size: 2.9 cm. Tumor site: Right posterior midpole. Tumor focality: Unifocal. Sarcomatoid features: Not identified. Tumor necrosis: Not identified. Microscopic tumor extension: Extension into perinephric tissue: Not identified.. Extension beyond Gerota's fascia: Not identified. Extension into renal sinus: Not identified.. Extension into renal vein: Not identified. Extension into collecting system: Not identified.. Surgical margins: Renal parenchymal margin negative by at least 0.3 cm. Lymph-vascular invasion: Not identified. Pathologic findings in nonneoplastic kidney: No additional findings. Pathologic staging: pTla. C. Additional precaval lymph node: One lymph node, negative for malignancy (0/1). CLINICAL INFORMATION: Right renal mass. SPECIMEN(S) :
+
+--- Page 2 ---
+Page 2 of 3 A:Precaval lymph node B:Right renal mass C:Additional precaval lymph node. : A1 B1 B2 B3 B4 C1 PRELIMINARY INTRAOPERATIVE DIAGNOSIS: Intraoperative Pathologist(s): A. Precaval lymph nodes, frozen section diagnosis: Negative for malignancy. GROSS DESCRIPTION: Performed by A. Received fresh labeled and "precaval lymph node" is a 2 cm fatty lymph node entirely submitted for frozen section in one cassette labeled B. Received fresh labeled and "right renal mass". Procedure: Partial nephrectomy. Specimen laterality: Right. Tumor site: Right posterior mid pole. Tumor size: 2.9 x 2.5 x 2.0 cm. Tumor focality: Unifocal. Gross extent of tumor: Extension into perinephric tissue: Absent.. Extension beyond Gerota's fascia: Absent. Extension into renal sinus: Absent. Extension into renal vein: Absent. Extension into collecting system: Absent.. Adrenal gland: Absent. Gross Notes: Gross tumor characteristics: The tumor is 2.9 cm in maximum dimension and has a bright yellow-red color with focal necrosis. The tumor is at least 0.4 cm from the nearest inked parenchymal. margin.  The tumor is adherent to the pericapsular fat which is inked blue. Block summary for specimen 1) tumor with margin. 2-3) sections of tumor. 4) tumor with capsule. Fresh normal tissue and fresh tumor are submitted for C. Received fresh labeled and "additional precaval lymph node" is a piece of adipose tissue, 5 cm in maximum dimension. Within the adipose tissue is one fatty lymph node, 3.8 cm in maximum dimension. The entire lymph node is bisected and submitted in one cassette labeled. Support for the diagnosis in this case may have included the use of immunohistochemistry tests that were developed and whose performance characteristics were determined by They have not been cleared or approved by the U.s. Food and Drug Administration (FdA). The FDA has determined that such clearance or approval is not.
+
+--- Page 3 ---
+Page 3 of 3 necessary. These tests should not be regarded as investigational. or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 ('cLIa') as qualified to perform high complexity clinical laboratory testing.. 8/913
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diff --git a/output/text/3c5cacfe-f7e3-4e03-8892-6b30eb859ef5.txt b/output/text/3c5cacfe-f7e3-4e03-8892-6b30eb859ef5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d1cb32fff84fd15810c6bd7058cac67a40befceb
--- /dev/null
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+
+--- Page 1 ---
+SURGICAL PATHOLOGY REPORT Clinical Diagnosis & History:  Moderately differentiated adenocarcinoma in the sigmoid colon. No history of chemoradiation. Specimens Submitted: 1: sp: Sigmoid colon; resection 2: Sp: Proximal margin DIAGNOSIS: 1. SP: Sigmoid colon; resection: Tumor Type: Adenocarcinoma Histologic Grade:  Moderately differentiated Tumor Location: Sigmoid colon Tumor Size: Length is 1.1 cm. Width is 0.7 cm. Maximal thickness is 0.4 cm Tumor Budding: Absent Increased Tumor Infiltrating Lymphocytes: Absent Not identified Deepest Tumor Invasion: Submucosa Gross Tumor Perforation: Not identified Lymphovascular Invasion: Identified Large Venous Invasion: Not Identified Perineural Invasion: Identified Surgical Margins: Free of tumor Polyps/Mucosa Dysplasia (away from the carcinoma): ** Continued on next page **
+
+--- Page 2 ---
+ag Hyperplastic polyp; number:1 Non-Neoplastic Bowel: Diverticulosis Lymph Nodes: Number with metastasis:0 Total number examined:23 Tumor deposits in pericolorectal soft tissue: Not Identified Tumor Staging AJCC 7th Edition: pT1 Tumor invades submucosa) Lymph Node Stage (AJcc 7th Edition NO (No regional lymph node metastasis 2. SPPROXIMAL MARGIN,EXCISION: -BENIGN COLONIC TISSUE. 3. SP:DISTAL MARGIN,EXCISION: -BENIGN COLONIC TISSUE. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OFS THE SLIDES (AND/OR OTHER MATERIAL),AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Gross Description: 1. The specimen is received fresh, labeled "sigmoid colon and consists of a segment colon measuring 16.2cm in length with a circumference of 5.0 cm at the stapled resected margin and 4.8 cm the open resected margin. Focally hemorrhagic lobulated yellow tan adipose tissue spans the length of the specimen measuring up to 1.5 cm in thickness. The specimen is opened to reveal an ulcerated mass lesion measuring 1.1 cm in length and 0.7 cm in width.The mass is located 10.0 cm from the stapled margin and 6.3 cm from the open margin. Sectioning shows that the tumor invades the submucosa. The depth of invasion is 0.4 cm grossly.They is a 0.1 cm polyp located 3.0 cm from the open resection margin.There are several diverticuli with. associated muscular wall and pericolic adipose tissue thickening. The remaining mucosa is grossly unremarkable. The attached adipose tissue is thoroughly examined and ali identified lymph nodes are submitted. Representative sections of the specimen are submitted for permanent sections and for TPS. Summary of sections: S -stapled margin shave 0-open margin shave tumor,entirely RS -0.1 cm polyp and representative section from colon DIV- diverticuli LN-lymph nodes ** Continued on next page **
+
+--- Page 3 ---
+2). The specimen is received in formalin, labeled "Proximal margin" and. consists of a silver metal anastomotic pin measuring 7.5 x 2.8 x 1.5 cm.. At the center of the pin, a white plastic piece is noted. A ring of pink tan. soft tissue is attached measuring 1.8 x 1.5 x 1 cm. The mucosal surface is. pink tan and focally hemorrhagic and the serosal surface is pink tan and smooth. Several sutures and staples are noted. The sutures and staples are removed and the soft tissue is entirely submitted.. Summary of sections: U  undesignated 3). The specimen is received in formalin, labeled "Distal margin" and consists of a ring of pink tan soft tissue measuring 2.5 x 1.5 x 0.7 cm.. Multiple sutures and staples are attached..  The mucosal surface is pink tan and focally hemorrhagic.  The sutures and staples are removed and the soft. tissue is entirely submitted.. Summary of sections: U - undesignated Summary of Sections: Part 1:  SP: Sigmoid colon; resection. Block Sect. Site pCs 2 div 2 5 1n 4 1 0 rs 1 12 1 2 Part 2: SP: Proximal margin Block Sect. Site PCs 1 U 1 Part 3: SP: Distal margin Block Sect.  Site PCs 1 U 1 ** End of Report *
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diff --git a/output/text/3c8bf931-f78a-431b-8ce2-9f5574ab21e9.txt b/output/text/3c8bf931-f78a-431b-8ce2-9f5574ab21e9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..682f8a3ace0c9c803ff05c39ca1b51e71f9e980e
--- /dev/null
+++ b/output/text/3c8bf931-f78a-431b-8ce2-9f5574ab21e9.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+ Patient: Referring Physician: UUID: 4D864947-076C-4A66-940D-682E75E525A2 TCGA-AC-A3BB-01A-pR Redacted DOB: Age:  Gender:F Ref#: Hosp#: Patient Location: Date of Service: Date Received: Outpatient Case #: Room: : Bed: Date Reported: A copy of this report will be faxed to: FINAL SURGICAL PATHOLOGY REPORT Diagnosis: BREAST, RIGHT, MODIFIED RADICAL MASTECTOMY: - Invasive lobular carcinoma, grade 2. - Tumor size at least 65 mm, see comment. - Surgical margins negative. - Five of fourteen lymph nodes POsITivE for carcinoma (5/14). - Extracapsular extension identified.. 1es-o-3 Caciome,ifi1tratng 1obuJav, Nvs 8'5X0f3 Site: brusot, Nos. c50.9 h iojas|H PATHOLOGIC TUMOR STAGING SYNOPSIS: Type and grade (invasive): Invasive lobular carcinoma, grade 2. Type and grade (in situ): Lobular carcinoma in situ. Primary tumor: pT3.. Regiona! lymph nodes: pN2a (5/14 lymph nodes positive). Distant metastasis: pMX. Pathologic stage: IIIA. Lymphovascular invasion: Not identified. Margin status: R0, negative. COMMENT: The tumor size is measured at least 6.5 cm grossly, however, there is a second tumor mass grossly noted that shows similar histology to the large tumor mass grossly noted. On random sections between the two tumor masses, invasive Iobular carcinoma is seen, therefore, these masses are considered to be one large tumor mass rather than two separate masses (overall gross estimate of 14 cm) Results discussed with Dr. Case #: Page 1 Printed: This report continues... (FINAL) Phone: Fax:
+
+--- Page 2 ---
+Case #: FINAL SURGICAL PATHOLOGY REPORT Breast Invasive Tumor Staging Informatlon (AJCC Cancer Staging Handbook, 7th Ed, and CAP protocol, Oct 2009) This staging also incorporates: Previous biopsy: Breast proflle: Other: N/A. Total breast including nipple and skin.. Specimen type: Modified radical mastectomy. Specimen procedure: Axillary dissection. Lymph node sampling: Single intact specimen. Specimen integrity: Specimen laterality: Right. Specimen size (other than mastectomy):. 2,220 grams, 28 x 23 x 6 cm. INVASIVE TUMOR FEATURES: Invasive tumor size: At least 65 mm. Invasive tumor site: Upper outer quadrant. Invasive tumor focality: Single focus of invasive carcinoma. Histologic type: invasive lobular carcinoma.. Total Nottingham Grade: Grade 2, cumulative score 6 of 9. Less than 5% (3 of 3). Tubule formation: Nuclear Pleomorphism: Intermediate (2 of 3). Mitotic count for Nottingham: Low (1 of 3). Two per ten high power field. Mitotlc count: Other Grading System: N/A. Lymphatic invasion: Not identified. MARGIN STATUS FOR INVASIVE COMPONENT: R0, negative. Distance of tumor from margins: Closet margin: Deep at 15 mm. Other margins:  All other margins 15 mm or greater. DUCTAL CARCINOMA IN-SITU (DCIS): Not identified. LOBULAR CARCINOMA IN-SITU (LCIS):E Present. Skin: Present, invades skin, no ulceration or. lymphovascular invasion Nipple: Present, tumor invades nipple. Skeletal Muscle: Not identifled. INVASIVE PATHOLOGIC TUMOR STAGING (pTNM) Prlmary tumor (pT): pT3.
+
+--- Page 3 ---
+FINAL SURGICAL PATHOLOGY REPORT Regional lymph nodes (pN): pN2a (5/14 iymph nodes POSITIVE) Distant metastasis (pM): pMX. Pathologic stage: IIIA. RECEPTOR STATUS AND HER2/NEU: Estrogen receptors:. POSITIVE (95-100% positive cells, strong intensity). Progesterone receptors:. POSITIVE (90-100% positive cells, strong intensity). Negative (0, scale 0-3+) Her2/neu: Ki-67 proliferative index:. Low (2-5% positive cells). COMMENT: The biomarkers are combined from previous cases and show a similar stalning pattern. The patient had two previous biopsies, however, on. the mastectomy specimen, there are two identified masses, however, there is intervening tumor cells and both tumor masses show a similar histology, therefore, it's felt to represent. one large tumor mass. In addition to the five  macrometastases seen in the fourteen lymph.  nodes, two additional lymph nodes show isolated tumor cells (and are not included in the five positive nodes).. Additional pathologic findings: Apocrine metaplasia, atypical lobular hyperplasia, usual ductal hyperplasia. . MD, Signed by Source of Speclmen: Right Breast total mastectomy Clinical Historv/Operative Dx:. Right breast cancer. Gross Descrlption: The specimen is labeled right breast modified radical mastectomy and is received without fixative. it. consists of a modified radical mastectomy which weighs 2,220 grams. Overall, the specimen measures 28 x 23 x 6 cm. There is an overlying broad ellpse of brown skin measuring 30 x 19.5 cm. Centrally and. slightly superiorly within the skin, there is a 7.5 cm areola and a protuberant 1.5 cm nipple. The peripheral skin displays five sharply delineated dark brown, smooth, shiny papules. The anterior-superior. margin is inked blue, the anterior-inferior margin is inked green, and the posterlor margin, which consists of smooth facial tissue, is inked black. Axillary tissue is present with at stitch marking the axilla. The axillary tail measures 10 x 5 x 2 cm. In the lower outer quadrant of the breast, there is palpably firm and hemorrhagic breast parenchyma which is very poorly delineated. There is some bright yellow discoloration of the associated fatty tissue. This area of firm fibrous parenchyma involves an area Case #: Page 3 This report continues... (FINAL) Printed: Phone:
+
+--- Page 4 ---
+Case #: FINAL SURGICAL PATHOLOGY REPORT measuring 6.5 cm from medlal to lateral, 5.5 cm from superior to Inferior, and up to 3 cm from superficia! to deep. The flbrous tissue is 4 cm from the closest inferlor margin, 12 cm from the closest superior margin, 9 cm from the closest medial margin, and 11 cm from the closest lateral margin. It is 2.5 cm from the closest deep margin, and 2 cm from the closest skin. Representative sections of this tissue are obtained for research purposes. Further examination of the breast reveals scattered moderately dense, tan-white fibrous parenchyma throughout all four quadrants. in the lower outer quadrant of the breast centrally, 5.5 cm lateral to the palpably firm breast tissue, there is an additional ll-defined 2 cm area of moderately dense fibrous tissue with very focal bright yellow discoloratlon of the surrounding fat. This lower outer quadrant fibrous parenchyma is 1.5 cm from the closest margin which is the deep margin. It is 5 cm from the closest lateral margin, and greater than 5 cm from all other margins, except for the skin where it is 1.8 cm from the skin. There are multiple palpable flrm nodes within the axillary portion of the dissection. Representative sections are submitted. Section summary: A1) nipple and tissue just deep to nipple,. A2) representative skin including small papules, A3) sections from medial edge of palpably firm and fibrous tissue, A4-A6) central sections of firm neoplastic tissue submitted from superior to inferior, A7-A8) representative sectlons of lateral edge of fibrous tissue, A9) representatlve section of fibrous tissue from far lateral lower outer quadrant, A10) representative deep margin far lateral lower outer quadrant, A11) representative deep margin central breast underlying palpably firm tissue, A12) representative tissue from upper inner quadrant, A13) representative tissue lower inner quadrant, A14) representative tissue upper outer quadrant, A15) representative sections of lower outer quadrant (in between palpable central tumor and far lateral lower outer quadrant sections),. A16) representative sections of largest 2.7 cm node (grossly suspicious for tumor), A17) single node, bivalved (grossly suspicious for tumor), A18) single node, trisected (grossly suspicious), A19) single node, trisected,. A20) two nodes, inked and bivalved, one possible node intact, A21) one node, inked and bivalved, possible smaller nodes intact, A22-A25) additional sectlons following reexamination for possible lymph nodes. Microscopic Description:. Microscopic sectlons have been examined. The microscopic findings are reflected in the diagnosis rendered. immunohistochemistry was performed with adequate control for OSCAR keratin. Page 4 Case #: REPRINT: Orig. printing on Printed: Phone: Fax:
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new file mode 100644
index 0000000000000000000000000000000000000000..2f88dfa21040e8649c13aa1f91e422d6391d5019
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+LCD-0:3 UUID: B3ABA98A-0D0D-493C-9F20- E8B7E3A935EB TCGA-2Z-A93M-01A-PR Redacted Wrcinsm@, yelpillosy renal ceQQ 8q60/3~ Site. OKiiny NoS Cb49 Pathology Report O 47281y Final Diagnosis A. LEFT KIONEY: Renal cell carcinoma, papillary type 1, Fuhrman nuclear grade 2, two separate foci,contined to kidney measuring 0.7 cm and 2.5 x 2 x 1.7 cm. (See Key Pathological Findings and See Comment). Resection margins (ureteral, vascular and peripheral soft tissue), free of tumor. Multiple papillary adenomas (17). Acquired cystic disease of kidney. Pathologic stage (for both foci): pT1a NX MX. the attending pathologist, personally reviewed all. Signed out by Comment Immunohistochemical stains performed on the larger renal cell carcinoma, shows the tumor cells to be positive for vimentin, cytokeratin 7, AMACR, and focally positive for CD10. The immunoprofile supports the above diagnosis.lmmunohistochemical stains performed on papillary adenomas show positive staining for cytokeratin 7,AMACR, and focal positivity for CD10. Immunohistochemical stains performed on one of the cystic lesions shows lining epithelial celis to be focally and weakly positive for CK7 and negative for CD31. Key Pathological Findings Tumor type:  Renal cell carcinoma, papillary type 1, two separate foci. Nuclear grade: 2 Pattern of growth:  Papillary Tumor size: 2.5 x 2 x 1.7 cm and 0.7 cm Renal capsule invasion: Not identified Invasion of perinephric adipose tissue: Not identified. Renal vein invasion: Not identified Surgical margins: Free of tumor Ureteral and vascular margins: Free of tumor Lymphovascular invasion: Not identified Non-neoplastic kidney. Acquired cystic disease of kidney and changes consistent with. patient's history of end-stage renal disease Adrenal gland: Not identified Lymph nodes: Not identified Pathologic stage: pT1a NX MX Specimen(s) Received
+
+--- Page 2 ---
+A LEFT KIDNEY Clinical History Endstage renal polyarteritis nodosa with living related donor right renal transplant in Preoperative Diagnosis Left kidney mass. Gross Description A. The specimen received fresh labeled *teft kidney". The specimen consists of an 82 gram, 5 x 3.5 x 2.8 cm kidney which is surrounded by perinephric adipose tissue ranging from 0.1 to 0.8 cm in thickness. Prior to sectioning the perinephric adipose tissue resection margin is inked black. There is a. 2-cm length of ureter attached to the kidney which is grossty unremarkabie. The specimen is seriay sectioned to reveal an irregular to roughly soft-to-rubbery intraparenchymal tumor which measures 2.5 x 2 x 1.7 cm. The tumor involves the cortex and medulla of the superior lateral aspect of the kidney.. The tumor bulges but does not appear to extend through the renal capsule and is within 0.3 cm of the closest perinephric adipose tissue resection margin. The cut surface of the tumor is pale-yellow to pink, lobulated, without evidence of necrosis or hemorrnage. Neither calices nor renal pelvis are involved by the tumor. The renal artery and vein and their branches do not appear to be involved by the tumor. At least 17 satellite intraparenchymal and subcapsular tumor noduies are identified ranging from 0.1 to 0.7 cm in greatest dimension. There are also several subcapsular and intraparenchymal. cysts which range from 0.3 to 0.6 cm in greatest dimension. The cysts are filled with transparent fluid. The remaining renal parenchyma is tan-red-brown.The atrophic cotex ranges from 0.2 to 0.5 cm in thickness.Urothelium of the calices,renal pelvis, and the portion of ureter, is tan,smooth and glistening..No lymph nodes are found within hilar adipose tissue. No adrenal gland is identified within superior pole of the specimen. Representative sections of the specimen are submitted to the Tissue Procurement Laboratory. Representative sections of the specimen are submitted in 16 cassettes as follows: A1: Resection margin of the renal artery A2: Cross sections of the proximal portion of ureter A3: Renal pelvis A4-A8: Representative sections of the tumor overlying renal capsule and adjacent perinephric adipose tissue A9-A16:Additional sections of the renal parenchyma with multiple satellite tumor nodules and subcapsular and intraparenchymal cysts. A17:  Resection margins of ureter and renal vein Representative sections of the specimen are submitted to the Tissue Procurement Laboratory. HIPA ISQUALIFIED
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diff --git a/output/text/3ca4b710-e69f-41f4-b7d2-e74b80fd93ba.txt b/output/text/3ca4b710-e69f-41f4-b7d2-e74b80fd93ba.txt
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+UUID: FAA3F68D-0FB9-44E4-AFEF-7DC1662BE783 ID-O3 Qrsnoms,WrstheleiQ N6S 31 20f3 SPECIMEN 1. Bladder Carwnsmo>, tranilienol cellNoS 8/zs/3 2. Right obturator lymph node 3. Right external iliac. Site: Ylosder, Sotiral wall cb7.2 4. Left external iliac. QJ s%|14 5. Left obturator lymph node 6. Right ureteric resection margin. 7. Left ureteric resection margin CLINICAL DETAILS Radical cystectomy for invasive cancer MACROSCOPY 1. A radical cystectomy specimen comprising bladder measuring 55 x 50 x 45mm urethra 35mm in length and stump of cervix 23mm in length. There is no uterus or adnexae. Within the bladder there is a fungating tumour on the left lateral wall and superior wall measuring 35mm x 22mm x 13mm. The specimen includes the entire anterior wall of the vagina and the urethral margin includes vulval mucosa. The tumour extends through the bladder wall into the perivesical soft tissue. 2. Piece of fatty tissue 91 x 32 x 12mm containing six lymph nodes, the largest 28mm maximum dimension. 3. Piece of fatty tissue measuring 64 x 8 x 7mm containing two lymph nodes, the larger 10mm maximum dimension. 4. Piece of fatty tissue 58 x 12 x 6mm containing two lymph nodes, the larger 14mm maximum dimension. 5. Fatty tissue measuring 61 x 32 x 15mm containing five lymph nodes, the largest 21mm maximum dimension. 6. A segment of ureter measuring 5 x 3mm. 7. A segment of ureter measuring 10mm in length, 5mm diameter with an attached suture. MICROSCOPY Pw T35,5% squomous 1. The tumour is a poorly differentiated (WHO grade 3) transitional cell carcinoma, with a largely solid growth pattern. Foci of necrosis and squamous differentiation are noted. No carcinoma in situ is seen in the adjacent or background urothelium. The macroscopic impression of tumour extending beyond the muscularis propria is confirmed microscopically (pT3b). There is tumour invasion into medium sized muscular arteries. The closest margin is the left lateral serosal margin which lies 2mm away. No lymphovascular or perineural invasion is identified. The tumour does not invade into the vagina. The urethral margin is morphologically normal with no evidence of dysplasia or in situ changes. All the surgical margins are clear of tumour. 2. Six nodes have been examined, none of which are involved by metastatic tumour. 3. Two nodes have been examined, neither of which are involved by metastatie tumour. 4. Two nodes have been examined, neither of which are involved by metastatic tumour. 5. Five nodes have been examined, none of which are involved by metastatic tumour.
+
+--- Page 2 ---
+6. Ureteric tissue with no infiltration by tumour. 7. This is ureter which shows no carcinoma in situ or invasive malignancy SUMMARY G3 transitional cell carcinoma of bladder, (pT3b pN0 pMx). Surgical margins clear of tumour. Pathologists - Dr DR CONSULTANT lW 3/H1y
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diff --git a/output/text/3cad3dc8-230b-48a3-9f4c-c47f47bed387.txt b/output/text/3cad3dc8-230b-48a3-9f4c-c47f47bed387.txt
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index 0000000000000000000000000000000000000000..9d5cd7fd7c8750cd3d41a3a1f04b6d37bdda81f7
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+P.18/33 NAL DIAGNOSIS: PARt t: SENTINel LyMPH nODE #1. LEfT AXILLA, BIOPSY -- A.  mETASTATiC CARCINOmA inVOLVEs ONE LympH NODE AND fORMS A SiNGLe TUmOR DEPOSiT IN ADJacent soFt t'issue (1.3 cm) (slide 1a). B. The meta9tatic focus in the Lymph node is almost entirely replacing the lympii none. ParenchvMa (0.R Cm) with extracapsuI_AR ExtensiOn (0.7 X 0.3 Cm). PARt 2: BREaSt. LEFT mODIFIed RaDICaL mAstEctOmy AND LEft AXILLARy COntEnTS -  A.  invasiVe DuctaL cARcinomA, TwO FOci, 3.2 Cm anD 1.5 Cm (grOss) at 6 and 10 O'ClOck pOsiTiOn respectively, notnngham Grade 1/3 (combineD notTingham score si9: tubule formation 2/3. NuclEar atypia 2/3. mitotic act!yity 1/3) wth LOBuLar features (eo0 comment). B. TumOr InVaDes inTO SkelEtAL mUsCle FIBErs. Ductal Carcinoma in-sitU,nucLear GrAbe 2, criBriform Type Associateo wiTh invasive tumOr AND COmpRISiNg 1% Of TUmOR MASS. LYMPHOVASCULAR INVASION IS IDENTIFIED. mAKGiN:i FKEt JUMOR wITHIN LE58 TMAn t mm rnUm DtEP MARGIns iN BOTH THE 6 O'CLOCK AnD 10 O'clock position. F. Uninvolved breast.Parenchyma with fibrocystic Changes. SRin and ni ple free or iumor. G. H.  MeTASTATiC CArcINQmA invOLVE3 TwO OF NINe LyMpH NODEs (2/9) AnD FORMS fiVE TUmOR DEPOSITS IN AXILLARY SOFT TISSUE. 4. LARgest TumOr:size in The Lymph nODe iS 1.0 Cm WiTh ExtrAcApsULaR ExTen5iOn (0.9 Cm.) J. AxilL'ary soft'tissue tumor deposit range from o.2 to 0.6 Cm. K. PATHOLOGIC STAGE (eCC conmunt). 1c0-0-3 L. Er IPR : POSITIVE, HER-2IneU . NEGAtIVe (PERfORmed ON BIOPSY). Cavcimoma, nf4fnsfg duct,nos 85o/3 Part 3: ADdftional Left axiLLary Contents, giopsy -- l50.9 3f3fn hJ A. :MEtAStATICCArcInOMA InVoLViNG FiBROaDiPOSe TiSsUe (TumOr DErOSiT). Sih: brst, Nts B..TUMORMEASURE8 0.6 X 0.5 CM (MICROSCOPIC) CASESYNOPSIS: 3YNOP?IC - PRiMARY:INVASIVE CARCINUmA'UF BREAST LATERALITY: Lef PROCEDURE:  Mouified radical maslcctomy Locatiun: Urpar mner quadrant Lower ouler guadrant Lower inner quadrant SIZE OF TUMOR: Maximum dImenskn invasive componenl. 3.2 cm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: Yos Tumor aggregate size: Sum ol Ino sizee of multiple invasive tumars: 4.7 cm TUMOR TYPE (invaslve component): Duatal adenocarcinomu. NOS NOtTinGhAm SCOre: Nuclear grade. 2 Tubule formstion: 2 Mitotic activity score 1. Total Noninghem score: b Notingham grude (1. 2. 3) 1 ANGIOL YMPHATIC INVASION: Yes DERMAL LYMPHATIC INVASION:S No CALCIFICATION: No TumoR type, In situ: Crbntorm Fercemt or tumor occupicu by in sili component: 1 %. SurgicAl mArgins InvolVed by Invasive coMponent- No SURG MARGINS INVOLVED BY IN SITU COMPONENT: No Paget's disease of nipple: No Lymph nodes positive: 9 LYMPH NODES EXAMINED: 9 methOD(s) OF Lymph nODE exAmInAtiOn: 1VC stain SENTINEL NODE METASTASIS: Yes SIZE OF NODAL METASTASES: Dlameter of lergest lympth nude melastasic: 10 mm LYMPH NOOE METASTASIS(-ES) WITH EXTRACAPSULAR EXTENSION: Yos SKIN INVOLVED (ULCERATION): No NON-NEOPLASTIC BREAS) II3SUE: FC T stage. Patmologic: pT2 N sTage, paTmoLOgIC: pN2 m Stage, pathologiC: pMX Estrogen receptors: positive PROGESTERONE RECEPTORS: posilive HER2INEU: <e1o cr 1+  (cir 3/13/ UUID: 3A0E1EF6-B234-46EC-BD15-95B5FAB06D45 TCGA-BH-A0DV-01A-PR Redacted
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+UUID: 821ED144-DF12-4E49-ADC7-27FA5E422883 TCGA-UU-A93S-01A-PR Redacted SUrGICAL PAtHOLOgy REPORt Patient:  Accession: DOB: Sex: F Account:  Date Collected: Date Received: MRN: Patient Date Reported: Requested by:  Copy to: Clinical Data: Right breast mass final pathologic Diagnosis 1. Pectoralis muscle: Invasive poorly differentiated carcinoma consistent with a breast primary. See synoptic report.. Cautery artifact noted. 2. Right breast, mastectomy (2,374 grams):  Invasive poorly differentiated carcinoma consistent with a breast primary. See synoptic report. NCS SynOPTIC REPORT Procedure: Mastectomy Carsunoma iryiItatirg cuct ssej3 Lymph node sampling: Not performed Sste  J@uaetNDs Cso.9 Specimen laterality: Right Invasive carcinoma invoives all quadrants Tumor site: Histologic type of invasive Invasive ductal carcinoma carcinoma: Tumor size: 19 cm Histologic gra de (Nottingham Histologic Score): . Glandular/tubular differentiation: Score 3 . Nuclear pleomorphism: Score 3 - Mitotic rate: Greater than 8 mitoses/mm?, score 3 - Total overall grade: 9, grade III (G3) Tumor focality: Single focus of invasive carcinoma Ductal carcinoma in-situ: Not identified Skin/nipple: There is ulceration of the skin by tumor. There is dermal lymphatic invasion.. Skeletal muscle: Carcinoma invades the skeletal muscle. Margins: Invasive carcinoma is identified at the deep margin including involvement of the. skeletal muscle.  Invasive ductal carcinoma is identified within 0.2 cm of the superior skin/soft tissue. margin. Lymphovascular invasion: Identified including dermal lymphatic invasion Calcifications: Present in invasive carcinoma Page i ot 2
+
+--- Page 2 ---
+SURGICAL PATHOLOGy REPORT - COnTINUED Patient: Result ID: Accession: Ancillary studies: ER, PR and HER-2/neu studies have been ordered on block E and will be reported. separately Pathologic Tumor Stage:. pT4d NX Pathologist, Electronic Signature. SPECIMEN(S) SUBMITTED: GROSS DESCRIPTION 1. Pectoralis muscle: Received fresh for frozen section diagnosis is a single segment of skeletal muscle with attached fibroadipose tissue and soft tissue measuring 6.5 x 4.0 x 1.5 cm. The specimen is unoriented. One surface is inked black. and the opposite surface is inked orange. The specimen is serially sectioned and entirely submitted for frozen section  diagnosis in three cassettes. The frozen section remnant is submitted in cassettes A - C. 2. Right breast: in formalin labeled with the patient's name and medical record number is a 2374-gram, 26 x 18 x 11 cm right simple mastectomy surfaced by brown skin. The specimen is oriented with a short stitch designated as superior and a long stitch as lateral. The skin surface displays a 19 x 15.5 cm nodular gray-yellow mass involving the entire nipple areolar complex. The nipple is not definitively identified.. The mass comes to within 1.5 cm of the inferior skin margin, 2.5. cm of the superior skin margin, 1.8 cm of the lateral skin tip, and 8 cm of the medial skin tip. The superior skin margin is inked blue, the inferior skin margin is inked green, and the deep margin is inked black. Upon sectioning the mass involves all four quadrants and approaches 1 the deep margin. Red-brown muscle is identified at the deep margin, which also appears to be involved by tumor grossly. The cut surface of the mass is pink-gray to tan-yellow, firm, and glistening. The mass occupies approximately 80% of the breast parenchyma. The remaining cut surface displays yellow adipose tissue intermixed with dense tan-white fibroglandular tissue. Representative sections are submitted in nine cassettes as follows: A - B - superior skin margin, C -  - the inferior margin, E. - mass to include the deep margin, G - the deep margin to include muscle, H - I - the mmass to inciude skin invoivement. The specimen is placed in formalin at. giving a total formalin fixation time of approximately 8.5 hours.. INTRAOPERATIVE REPORT: Frozen Section Diagnosis: Carcinoma present, involving skeletal muscle CPT CODE(S): ICD-9 CODE(S): Facility: 88331, 88307, 88305 [1749] /2/13 EnD Of REpORt Prior Ma DISQUALIFIED
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diff --git a/output/text/3cc5b483-a8e8-401a-8122-cfc339c14775.txt b/output/text/3cc5b483-a8e8-401a-8122-cfc339c14775.txt
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index 0000000000000000000000000000000000000000..844f886b25cbe146f60d58468e2c6932bf1519b0
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+--- Page 1 ---
+UID:E6740AC4-64A2-4E53-8878-74C7EF3C9FAA0 TCGA-2Z-A93S-01A-PR Redacted Pathology Report Final Diagnosis A. LEFT KIDNEY, PARTIAL NEPHRECTOMY: Renal cell carcinoma, papillary type ll. See Key Pathologic Findings. Pathologic stage: pT1a NX MX. B. DEEP MARGIN: Renal parenchyma, no evidence of malignancy. the attending pathologist, personally reviewed all slides and / or materials and rendered the final diagnosis. Electronically Signed out by IaD-o3 Key Pathological Findings A: Kidney Resectior PROCEDURE 8QbO|3 Partial nephrectomy Sute BFidny NoS SPECIMEN LATERALITY: Left C649 TUMOR SIZE (largest tumor if multiple): Dimension: 2.2 cm MACROSCOPIC EXTENT OF TUMOR: AU 4/Q8J14 Tumor limited to kidney HISTOLOGIC TYPE: Papillary renal cell carcinoma SARCOMATOID FEATURES: Not identitied TUMOR NECROSIS: * 2% HISTOLOGIC GRADE (Fuhrman Nuclear Grade): -l. predominanty  MICROSCOPIC TUMOR EXTENSION Tumor limited to kidney MARGINS:  Final surgical margin, free of malignancy PERINEURAL INVASION: Absent ANGIOLYMPHATIC INVASION: Absent LYMPH-VASCULAR INVASION: Absent PRIMARY TUMOR (pT): pT1a:Tumor 4 cm or less in greatest dimension, limited to the kidney REGIONAL LYMPH NODES (pN):
+
+--- Page 2 ---
+pNX: Regional lymph nodes cannot be assessed DISTANT METASTASIS (pM): pMX Specimen(s) Received A LEFT PARTIAL NEPHRECTOMY FS B DEEP MARGIN FS Preoperative Diagnosis. Left renal tumor Intraoperative Consultation. FSA1. LEFT PARTIAL NEPHRECTOMY: Renal cell carcinoma, margin free of tumor.. FSB1.  DEEP MARGIN: Negative for malignancy. This frozen section diagnosis was communicated to , M.D., have performed the intraoperative consuitation (s) and issued the above diagnosis. Gross Description. A.  The specimen is received fresh lateled "left partial nephrectomy" and consists of a 3.0 g, 2.5 x 2.0 x 2.0 cm partial nephreclomy specimen. The specimen has been oriented by the surgeon with. ink. The margin of resection is re-inked in black. The capsule is irregular, tan to tan-red. When sectioning the specimen a tan-yellowish, partially hemorrhagic and necrotic mass is noted measuring. 2.2x 1.5 x 1.0 cm located at 0.1 cm from closest inked parenchymal margin of resection.The margin of resection is submitted for frozen section evaluation as FSA1 and the remaining tissue is entirely submitted in cassettes A2 and A3. Representative tissue was submitted to Tissue Procurement. B The specimen is received fresh labeled *deep margin". The specimen consists of a fragment of dark red-brown soft tissue measuring 1.6 x 1.4 x 0.2 cm. The margin of resection had been marked. by the surgeon with ink and re-inked in blue. The specimen is entirely submitted for frozen section. evaluation as FSB1.
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diff --git a/output/text/3cd8c8de-2529-4c11-95bf-6d450a8ad959.txt b/output/text/3cd8c8de-2529-4c11-95bf-6d450a8ad959.txt
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+page 1 / 1 Department of Cancer Pathology Date: Examination: Histopathological examination Internal invoice No. Cost of diagnostic procedure Examination No.: Patient: XXX PESEL: XXX Age: Gender: Material: Total organ resection - sigmoid colon Unit in charge:  Physician in charge: Material collected on: Material received Expected time of examination: Clinical diagnosis: Cancer of the sigmoid colon. Examination performed on! Macroscopic description: A 18.2 cm length of large intestine with a segment of the mesentery sized 20.0 x 9.0 x 2.0 cm. Ulcerous tumour sized 4.3 x 4.4 x 0.7 cm in the mucosa . The lesion surrounds 100% of the intestine circumference and narrows its Iumen; it is located 12 cm from the incision line and 3.9 cm from the opposite one. The wall injected with blue dye. Outside the tumour, there is a 2 cm polyp and diverticula. Microscopic description: Adenocarcinoma tubulopapillare (G2). Infiltratio carcinomatosa superficialis telae adiposae mesenterii. Incision lines free of neoplastic lesions. Off tumour: Adenoma tubulare cum dysplasa gradus mediocrr (LG). Diverticula et diverticulitis Lymphonodulitis reactiva No V. Histopathological Diagnosis: Adenocarcinoma tubulopapillare coli. Tubulopapillar adenocarcinoma of the colon. (G2, Dukes B, Astler-Coller B2, pT3, pNO). Compliance validated by: CONTACT YOUR DOCTOR WITH THIS REPORT!
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diff --git a/output/text/3cdc9e43-9c3a-4a3e-bad9-77f1d8c12ab4.txt b/output/text/3cdc9e43-9c3a-4a3e-bad9-77f1d8c12ab4.txt
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+5/24t/n Jcs-0-3 Carcin`omt mfAnating duct Nos 85oof3 Site: busot, Nos C50.9 4 DIAGNOSIS (A) SENTiNEL LyMPH NODE #1, LEFT AXILLA, BIOPSy: One lymph node, free ot tumor. (See Comment) (B) SENTINEL LyMPH NODE #2, LEFT AXiLLA, BIOPSY: One lymph node, free of tumor. (See Comment). (C) LEFT BREAST, NEEDLE LOCALIZATION SEGMENTAL MASTECTOMY: INVASIVE DUCTAL CARCINOMA OF BREAST, MODIFIED BLACK'S NUCLEAR GRADE 3 (POORLY DIFFERENTIATED). INVASIVE CARCINOMA MEASURES 1.2 CM IN GREATEST DIMENSION. Lymphatic/vascular invasion is not identified. INTRADUCTAL CARCINOMA (DCIS), MODIFIED BLACK'S NUCLEAR GRADE 3 (POORLY DIFFERENTIATED), COMPRISING SOLID TYPE, WITH NECROSIS, COMPRISING <5% OF THE TUMOR AREA. INVASIVE CARCINOMA EXTENDS TO WITHIN 5.O MM OF THE NEAREST DEEP MARGIN All margins are free of tumor. (D) LEFT BREAST, SECOND DEEP MARGiN, EXCISION: Skeletal muscle, no tumor present.. (E) LEFT BREAST, SECOND MEDIAL MARGIN, EXCISION: UUID: 8CF4E53E-924F-40C6-8748-BC8A1F705662 No tumor present. TCGA-GM-A2DL-01A-PR (F) LEFT BREAST, SECOND SUPERIOR MARGIN, EXCISION: Redacted No tumor present. (G) LEFT BREAST, SECOND INFERIOR MARGIN: No tumor present. Entire report and diagnosis completed by v OMMENT Immunohistochemical stains for cytokeratins have been requested on tissue sections from both sentinel lymph nodes. Those results will be reported as an addendum. Molecular pathologic assays have been requested on tissue sections from block C1 of the primary tumor. Those results will be reported as an addendum. The invasive carcinoma measures 1.2 cm in greatest  microscopic diameter (slide C1) and focally invades pectoralis muscle, extending to within 5.0 mm of the deep margin (slide C2). GROSS DESCRIPTION (A) LEFT AXILLA, SENTINEL LYMPH NODE BIOPSY #1, IN VIVO 216, EX VIVO 4 - A 0.8 x 0.6 x 0.4 cm lymph node. The specimen is transected and two touch imprints were performed. The remnant of the tissue is submitted in toto in A. *TP/DX: NO CARCINOMA IDENTIFIED. (B) LEFT AXILLA SENTINEL BIOPSY #2, IN VIVO 416, EX VlVO 887 - A 2.0 x 1.0 x 0.6 cm lymph node with surrounding fat tissue. Specimen is bisected and two touch imprints are performed. A remnant of the lymph node is submitted in B1-B2. *TP/DX: NO CARCINOMA IDENTIFIED. (C) LEFT NEEDLE LOCALIZATiON, SEGMENTAL MASTECTOMY - A segmental mastectomy specimen (7.0 x 7.0 x 4.0 cm) with a skin ellipse (2.8 x 1.2 cm). The specimen has two clips indicating anterior aspect and one clip indicating the middle aspect. e specimen is serially sectioned from medial to lateral. The cut surface shows an ill-detined, white-tirm lesion measuring O.8 x 6 x 0.6 cm that is 0.7 cm trom the deep margin. The remnant of the breast tissue is predominantly composed ot fatty tissue. INK CODE: Green - inferior; blue - superior; black - deep; yellow - superficial; red - lateral; orange - medial. SECTiON CODE: C1-C2, tumor in relation to the deep margin; C3, extra section from the tumor; C4-C5, random section from the breast including the skin. ) SECOND DEEP MARGIN, CLIP ON TRUE MARGIN - An oriented irregular fragment of skeletal muscle measuring 3.0 x 1.5 x 5 cm. The specimen is oriented as clip on true margin. The true margin is inked in black. The specimen is serially sectioned and entirely submitted in D1-D2 (E) SECOND MEDIAL MARGIN, CLIP ON TRUE MARGIN - An oriented irregular fragment of adipose tissue measuring 4.O x 2.0 x 0.8 cm. The specimen is oriented as clip on true margin. The true margin is inked in black. The specimen is serially sectioned and entirely submitted in E1-E4.
+
+--- Page 2 ---
+(F) SECOND SUPERIOR MARGIN, CLIP ON TRUE MARGIN - An oriented irregular fragment of adipose tissue measuring 3.5 x 2.0 x 0.8 cm. The specimen is oriented as clip on true margin. The true margin is inked in black. The specimen is serially sectioned and entirely submitted in F1-F3.. (G) SECOND INFERIOR MARGIN - An oriented irregular fragment of adipose tissue measuring 3.5 x 2.5 x 0.6 cm. The specimen is oriented as clip on true margin. The true margin is inked in black. The specimen is serially sectioned and entirely submitted in G1-G3. 1 CLINICAL HISTORY Left breast cancer. SNOMED CODES T-04050, M-85003, M-85002, T-C4714, M-00110 "Some tests reported here may have been developed and performance characteristics determined by. These tests have not been specifically cleared or approved by the U.S. Food and Drug Administrauon.. Released by: Start of ADDENDUM ADDENDUM Addendum completed by -. COMMENT Immunohistochemical stains for cytokeratin were reviewed on tissue sections from both sentinel lymph nodes and were negative. Released by: Start ot ADDENDUM #2 ADDENDUM Addendum completed by' This report is issued to give immunohistochemistry results.. Immunohistochemical staining is performed on a representative section of INVASIVE DUCTAL CARCINOMA, left breast, block C1. RESULTS % POSITIVE MARKER STAINING INTENSITY Estrogen Receptor Positive 100 % N/A
+
+--- Page 3 ---
+5 Progesterone Receptor Positive 90 % N/A C-erbB-2 (HER-2/neu) overexpression Negative 0 % 0 Ki-67 High (>35%) 50 % N/A FootNoTe Estrogen receptor was assessed by immunohistochemistry using antibody 6F11 ( Progesterone receptor was assessed by immunohistochemistry using antibody 1A6 c-erbB-2 (HER-2/neu) was assessed by immunohistochemistry using antibody AB8 Ki-67 was assessed by immunohistochemistry using antibody MIB1 Released by:. ...-END OF REPORT...
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diff --git a/output/text/3d0e3be8-b958-4d20-bcf3-437d3d580cb1.txt b/output/text/3d0e3be8-b958-4d20-bcf3-437d3d580cb1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2eef6517ba6d384c1f053504f843f9e39de37a2e
--- /dev/null
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+Patient Name Accession #: Med. Rec. #: Date of Procedure DOB: Date of Receipt Gender Date of Repon Ref. Physician: Account # Patient Address' Billing Type. Additional Copy to: Ret. Source. Clinical Diagnosis & History: Right renal mass. Specimens Submitted: 1: SP: Kldney, right: partial nephrectomy DIAGNOSIS: SP: Kldney, right; partial nephrectom. Tumor Type Renal cell carcinoma - Papillary type (typo II) Tumor Size: Greatest diameter is 1.1 cm. Local Invasion (for renal cortical types):. Not Identified Renal Vein Invasion: Not identified Surgical Margins: Free of lumor Non-Neoplastic Kidney:  Unremarkable Adrenal Gland: Not identilied Lymph Nodes: Not idantified Staging for renal cell carcinoma/oncocytoma. pT1 Tumor <= 7.0 cm in greatest dimension timiteu to the kidney. REVIEWED AND APPROVED THIS REPORT SAOORMATRA AND  Page 1 of 2
+
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+Gross Doscription: 1). The specimen is received fresh for frozen segtion consultation, labeled "right renal tumor stitch marks deep surgical margin", and consists of a wedgo shaped portion of kidney with a suture marking the deep margin, neasuring 2.5 x 1.7 x 1.2 cm. The margin is inked black and the specimen is serially sectioned to reveal a sub-capsular yellow nodule measuring 1.1 x 1.0 x 0.5 cm. The clearance from the resection margin is 0.5 cm. A representative section of the nearest margin is submitted for frozen section diagnosis. Representatively submitted. Portions of the tumor are submitted for TPs. Part is submilted for frozen section. Summary of sections: F$C -- frozen section control T -entire tumor to margin UJ-- uninvolved kidney Summary of Sections: Part 1: SP: Kldney, right; partial nephrectomy Blocke Soct. Site. PCs fsc 2 ! 2 +** Intraoperative Consultation: Note:  The diagnoses given in this section pertain only to the tissue sample examined al the time of the intraoperative consultation. AGNOsiS:SP:Right renal tumo Ronal cortical neoplasm. Margin is free ol tunor. PERMANENT DIAGNOSIS: SAME F" Page ? of 2. END OF REPORT
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diff --git a/output/text/3d763550-2527-44cb-9259-3b4cae245d21.txt b/output/text/3d763550-2527-44cb-9259-3b4cae245d21.txt
new file mode 100644
index 0000000000000000000000000000000000000000..923762d283c2f6a2a2d0df7cb2d007f4a1feb684
--- /dev/null
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+--- Page 1 ---
+1cs-0-3 Carcin ma. infilfatg out,nos 85oo13 Pah: Siti Crdi: bruast, uppw ontwzusdient e50.4 Collection Date CQCF. bUst,Nrs c50.9 Date of Birth: Order Doctor: CLINICAL HISTORY ORIGINAL TEXT: Cancer left breast ORIGINAL VER ID GROSS EXAMINATION ORIGINAL TEXT : A. "Left breast", received fresh and placed in formalin. A 600 gram, 30.3 x 2.4 cm axilla, two at 24 x 8 cm ellipse of skin and 1.2 cm nipple with 4 cm areola is received. The specimen is marked with blue ink and sectioned to exhibit a 2.8 x 2.5 x 1.6 cm firm white mass towards the axilla.  The tumor comes to within 1.8 cm of the superior margin, 1.6 cm of the inferior margin, 2 cm of the posterior margin and 3 cm from the skin.. Areas of hemorrhage are. present around the site of the mass, consistent with the previous biopsy.. Al- tumor closest to superior border A2- tumor closest to inferior border A3- tumor closest to posterior border A4- tumor closest to anterior skin border. A5-6- upper outer quadrant. A7-8- lower outer quadrant  A9-10- upper inner quadrant Al1-12- lower inner quadrant A13- nipple A14- nine proximal lymph node candidates A15-16- nine mid lymph node candidates A17- four distal lymph node candidates A18- one distal lymph node candidate, bisected ORIGINAL VER .U UUID:983F0B22-8442-4720-A21B-7EF12CBCD2CE TCGA-B6-A0IO-01A-PRE DIAGNOSTIC CPT CODESS Redacted ORIGINAL TEXT: Container A: ORIGINAL VER ID DIAGNOSIS ORIGINAL TEXT: . "LEFT BREAST" (EXCISIONAL BIOPSY) : INVASIVE CARCINOMA OF THE BREAST. - MULTIFOCAL INVASIVE CARCINOMA: PRESENT. - SIZE (UPPER-OUTER QUADRANT): 2.8 x 2.5 X 1.6 CM. SIZE (LOWER-INNER QUADRANT) : 1 CM. N.S.A.B.P. HISTOLOGIC GRADE: 3 OF 3 - N.S.A.B.P. NUCLEAR GRADE: 3 OF 3. - LYMPHATIC/VASCULAR INVASION: NOT IDENTIFIED. IN-SITU CARCINOMA: PRESENT. TYPE OF IN-SITU CARCINOMA:| DUCTAL, (SOLID (MINIMAL CRIBRIFORM) . N.S.A.B.P. NUCLEAR GRADE: YOF 3. NECROSIS: PRESENT. teria Diagnosis Dis pancy HIPAA Discrepancy Dual/Synchronous se is (circle
+
+--- Page 2 ---
+ LOCATION: IDENTIFIED IN RANDOM SECTIONS OF THE UPPER-OUTER QUADRANT, UPPER-INNER QUADRANT, AND LOWER-INNER QUADRANT.S - SIZE: UNABLE TO DETERMINE. SURGICAL MARGIN STATUS: FRER OF TUMOR. NIPPLE: FREE OF TUMOR. SKIN: FREE OF TUMOR. MUSCLE: NOT IDENTIFIED. LYMPH NODE STATUS: - NO EVIDENCE OF MALIGNANCY IS IDENTIFIED IN SEVENTEEN LYMPH NODES (0/17). ESTROGEN/PROGESTERONE RECEPTOR, CELL CYCLE, AND HER2/NEU ANALYSIS: PENDING, THE RESULTS OF WHICH WILL BE REPORTED IN AN ADDENDUM. METHODOLOGY: IMMUNOHISTOCHEMISTRY, PARAFFIN BLOCK NUMBER A3. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es). ORIGINAL VER ID CI ADDENDUM 1 ORIGINAL TEXT: NUCLEAR ESTROGEN AND PROGESTERONE RECEPTOR ANALYSIS A tissue block was sent to the for assay of activity is judged to be posirivs with an estimated fmol/mg cytosolic protein value of 275.  Approximately 95% of the infiltrating carcinoma cells exhibit nuclear estrogen receptor expression. Benign ductal epithelium stains positively and serves as the internal control.  Results were obtained using a manual method with Signet antibodies and a detection kit. The PROGESTERONE RECEPTOR activity is judged to be BORDERLINE with an estimated fmol/mg cytosolic protein value of 6.  Approximately 1% of the tumor cells exhibit nuclear progesterone receptor expression.. Benign ductal epithelium stains positively and serves as the internal control. Results were obtained using a manual method with Signet antibodies and a detection kit. Please refer to for a complete report. HER2/neu IMMUNOHISTOCHEMICAL ANALYSIS Immunostaining for HeR2/neu (c-erbb-2) oncoprotein is performed on recut. sections of block A3.  The tumor cells exhibit no staining of their cell membrane (score - 0). indicating that they do not overexpress HeR2/neu Oncoprotein. METHOD  The immunostaining is done using DAko rabbit anti-human c-erbb-2 oncoprotein which is an affinity-isolated antibody ( . The immunostaining is performed after antigen retrieval by heating the. unstained sections at 95 degrees centigrade for 20 minutes in 10 mM citrate staining), with an incubation for one hour at 37 degrees centigrade. The Histostain Plus kit !. is used as the detection system. This test was developed and its performance characteristics determined by the Immunopathology Laboratory. It has not been cleared or approved by the FDA. The FDA has determined that such clearance or approval is not necessary. test is used for clinical purposes. This It should not be regarded as investigational or for research only.  This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIa) as qualified to
+
+--- Page 3 ---
+ high complexity clinical testing. PROLIFERATION INDEX IMAGE ANALYSIS A tissue block was sent to the. for assay of. proliferation index (block A3). The PROLIFERATION INDEx is judged to be HIGH with an estimated positive nuclear area percentage of 29%..  Please refer to for a complete report.. I certify that I personally conducted tha diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es).. ORIGINAL VER ID End of Report.
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diff --git a/output/text/3d7d7337-f8f1-4aea-a365-d2740debdac6.txt b/output/text/3d7d7337-f8f1-4aea-a365-d2740debdac6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..07fed1cc194a9e1288764aeb6b853e86698c7b00
--- /dev/null
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+
+--- Page 1 ---
+IcD-O-3 Site: Brsst NDs c50.9 Procedure Date: Procedure Physician:e Attending Physician/Copies To: UUID:809F294F-8C48-4719-866B-7169FB1CE24D PATIENT HISTORY:E TCGA-BH-A1EN-01A-PR Redacted + DATE Or LMP: * DATE OF LAST DELIVERY: PRE-OP DIAGROSIS: RT BR CA POST-OP DIAGMOSIS: SAME OPERATIVE PROCEDURR: RT SEG MAST CLINICAL HISTORY: * MATERIAL SUBKITTED: RIGHT SEGMENTAL MASTECTOMY, PROCUREMENT BY SURGICAL PROCEDURES INTRAORERATIVE CONSULTATIOM: FROzeN sEcrion: Right breast mass; portion of breast, 7.0 by 4.0 by 3.5 cm with ellipse of skin, 7.0 by 1.0 cm. Lobulated maas, 4.0*by 2.0 by 2.0 cm. Margins grossly free.. Frozen Section and Touch Prep Diagnosis: Infiitrating carcinoma with signet ring features. rteSr JIAgNOSIS: RIGHT BREAST, :SEGXENTAL MASTECTONY: CLOSEST SURGICAL MARGINS ARE SUPSRIOR AND DEEP (LESS THAN 1 MOX)S - SURGICAL MARGINS ARE FRER OF TOXOR IM PLANES OF SECTIONS NOTE: eR/pR ixmunoperoxidase assay and Her-2/wru will bo performed on block Al.. SUPPLEMENTALREPORT ER/PR My signature below is attestation that I have raviewed all slides and agree with tho findings as noted below. INSUNOPEROXIDASE IDKNTIFICATION Or ESTROGKN AND PROCESTERONE RECEPTORS IS CARRIED OUT ON SLIDE A1. KO DISTINCT INTRANUCLEAR STAINING IS IDENTIFIED YOR SITHER RECEPTOR. THERKFORE. BOTH ARK INTERPRETED AS NEGATIVE. SOPPLEXENTALRBPORT HEr-2/g80 Ny signature below is attestation that I have reviewed all slides and agree with the findings as noted below. c-erbB2 (HER-2/NEU) IMOUNOSTAISING IS CARRIED OUT ON BLOCX A1 (BRKAST CANCER) USINC A 1:3CO DILUTIOR OF DAKO'S POLYCLONAL ANTIBODY A4SS (DIRECTED AGAINST THE INTRACELLULAR DOMAIN OF c-erbB2) WITEOUT ANTIGEN RETRIEVAL. DISTINCT CONPLETE MEMBRANS STAIWING IS IDENTIFIED IN GO% Or TOXOR CELLS. THEREFORE, C-erbB2 (HER- 2/NEU) IS INTERPRETED AS POSITIVE (SCORE 3+).
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diff --git a/output/text/3d8f7ba2-fe5a-48ac-abce-72cebaa6f23c.txt b/output/text/3d8f7ba2-fe5a-48ac-abce-72cebaa6f23c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1e7e21bcb17cdc2a068a11e6bd80a56afeca8d53
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+1cs-0-3 Curci mmn,mfiltnsh'vg dutal wos 85o0f3 Site: buast, Nos C5s.9 3/uf page 1 / 1 Department of Cancer Pathology copy No. Date: Examination: Histopathological examination. Interna! invoice No. Cost of diagnostic procedure Examination No.: Patient: XXX PESEL: XXX Age: Gender: F Material: Multiple organ resection - left breast Unit in charge:  Physician in charge: Material collected or Material received on: Expected time of examination: 8 working days. Clinical diagnosis: Examination performed on: Results of immunohistochemical examination:. No estrogen receptors found in the neoplastic cell nuclei. Progesterone receptors found in less than 10% of the neoplastic cell nuclei. HER2 protein stained with HercepTestM by DAKO. Negative reaction in invasive cancerous cells (Score = 1+ ). Estrogen receptor was stained twice. Compliance validated by: Examination performed on:  Macroscopic description:  Right breast sized 15 x 9 x 3 cm removed along with axillary tissues sized 7 x 4 x 1 cm and a skin flap of 11 x 7 cm. Weight 650 g. Tumour sized 3.2 x 2.0 x 3.0 cm on the border of the upper quadrants, placed 2.0 cm from the upper edge and 1.5 cm from the base. Microscopic description: Carcinoma ductale invasivum NHG3 (3 + 3 + 3: 21 mitoses/10 HPF - visual area of 0.55 mm). Glandular tissue off the tumour showing lesions of the type mastopathia fibrosa et cystica, hyperplasia ductalis simplex (UDH). Axillary lymph nodes: Sinus histiocytosis cum microcalcificationes iymphonodorum (No xiI1). Histopathological diagnosis: Carcinoma ductale invasivum mammae sinistrae. Invasive ductal carcinoma of the left breast.. (NHG3, pT2, pN0). Compliance validated by CONTACT YOUR DOCTOR WITH THIS REPORT! UUID:1841FEE0-EC36-4EC4-8B5E-6D340C80735B TCGA-D8-A1JK-01A-PR Redacted 3/n(1 ]
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diff --git a/output/text/3d970321-0fbc-4d89-85c6-711d8ff4bc99.txt b/output/text/3d970321-0fbc-4d89-85c6-711d8ff4bc99.txt
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index 0000000000000000000000000000000000000000..b8226a014fd10086237f875b86fc78e90237574e
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+page 1 / 1 Examination: Histopathological examination. TCGA-D5-6540 Material: 1. Total organ resection - colon and caecum. Physician in charge:. Material collected on: Material received on: Expected time of examination Clinical diagnosis: Cancer of the caecum.. Examination performed on:. Macroscopic description: 15 cm length of arge intestine with a fragment of mesentery of 20 x 5 x 2 cm and a 10 cm segment of small intestine and a 7 cm appendix.. The mucosa in the caecum tinted green, a defect in the middle part of 2.5 cm in diameter. The defect placed 2 cm from the Baughin valve. Outer surface also tinted green.. Some small polyps of up to 0,6 cm in diameter found outside the tumour. Microscopic description: Adenocarcinoma tubulopapillare partim mucinosum (G3}. Infiltratio carcinomatosa tunicae muscularis propriae.. Minimum side margin is 0.6 cm. Excision lines free of neoplastic lesions. Off tumour: adenoma tubulopapillaria cum dysplasia gradus minoris. Polypus hyperplasticus verticulitis.. Sinus histiocytosis et lymphonodorum (No Xill).. Histopathology dlagnosis:.  Adenocarcinoma tubulopapillare partim mucinosum coli. Tubulopapillar and partially mucinous adenocarcinoma of the colon.. (G3, Dukes B, Astler-Coller B1, pT2, pN0). Compliance validated by:. CONTACT YOUR DOCTOR WITH THIS REPORT!
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diff --git a/output/text/3dded53d-b8cf-441e-b0c8-abb1c4b0bdea.txt b/output/text/3dded53d-b8cf-441e-b0c8-abb1c4b0bdea.txt
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index 0000000000000000000000000000000000000000..d11cc80b8a20c38891823425640eabae7327015e
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+
+--- Page 1 ---
+UUID:A1339B9A-538B-4864-9839-C8ED0F7888A2 TCGA-UZ-A9PV-01A-PR Redacted SURGICAL PATHOLOGY REPORT Patient Name Accession #: Med. Rec.#: Visit #: Service Date DOB: Sex: Male Received: Soc. Sec. #: Location: Client: Physician(s):1 Final Pathologic Diagnosis A. Left kidney, partial nephrectomy:. 1. Papillary renal cell carcinoma, 6.2 cm, Fuhrman grade 2, negative margins. 2. Arteriosclerosis. 3. Simple renal cyst. B. Left kidney, medial margin, partial nephrectomy: No tumor. ICDo 3 Comment: Kidney Tumor Synoptic Comment 'ersgnon, yaeillare - Histologic type: Renal cell carcinoma, papillary,type 1 ri naQ ceLl 8q6t|3 - Grade: Fuhrman grading for RCC: 2. - Tumor size: 6.2 cm. Siti DBedney N6S C649 - Site within kldney: Lower pole. - Intrarena! veins and Iymphatics: No tumor. - Adrenal gland: Not present. - Capsule/perirenal fat: Tumor does not penetrate the capsule. - Lymph node status: None present. - Resectlon margins: - Soft tissue: Negative; tumor is 0.05 cm from the margin (slide A7). - Renal parenchyma: Negative; tumor is <0.1 cm from margin (slide A8) - AJcc Stage: pT1NXMX. reviewed slide A7 and concurs with the diagnosis. was informed of the diagnosis on Specimen(s) Received A:Left partial kidney B:Medial margin left kidney - true margin inked Page 1 of 2
+
+--- Page 2 ---
+Clinica! History The patient is a. year-old male with a 5.2 minimally enhancing left lower renal mass suspicious for papillary renal cell carcinoma. The patient undergoes. a partial nephrectomy, including the mass suspicious tor renar cell carcinoma and an adjacent fluid-filled cyst. Gross Description The specimen is received in two parts, each labeled with the patient's name and medical record number. Part A is received fresh, labeled "partial left nephrectomy," and consists of a 185 gm, 9.3 x 7.1 x 5.2. cm, yellow to brown partial nephrectomy specimen. On cross-section, the specimen demonstrates a 6.2 cm, round, capsulated, yellow to red, soft mass consistent with renal cell carcinoma and an adjacent 4.5 cm clear fluid containing cyst with a smooth cystic lining. Additionally, the scant normal-appearing tan to brown kidney tissue contains smaller simple cysts. The entire external surface was inked black for. microscopic evaluation. Representative sections are submitted as follows: Cassette A1: Tumor with simple cyst wall and black ink.. Cassette A2: Tumor with kidney tissue and black ink.. Cassette A3: Tumor with black ink.. Cassette A4: Tumor with black ink.. Cassette A5: Tumor with kidney and perinephric fat with ink.. Cassette A6: Tumor with ink.. Cassette A7: Tumor with kidney and simple cyst, and renal parenchyma (surgical margin of kidney) with ink.. Cassette A8: Tumor with thin capsule.. Cassette A9: Tumor with ink. Cassette A10: Tumor with ink.. Part B, received in formalin and labeled "medial margin left kidney true margin inked," consists of a 2.5. x 0.5 x 0.5 cm triangular piece of brown tissue with no lesions grossly. The specimen is serially sectioned and entirely submitted in cassette B1, which is inked blue on the true margin and serially sectioned and entirely submitted in cassette B1.. Diagnosis based on gross and microscopic examinations. Final diagnosis made by attending pathologist following review of all pathology slides.. Pathology Resident athologist Electronically signed out o lw 19 g4 9013 Page 2 of 2
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diff --git a/output/text/3dec10c5-f0e2-4966-b9b6-0d98cd033884.txt b/output/text/3dec10c5-f0e2-4966-b9b6-0d98cd033884.txt
new file mode 100644
index 0000000000000000000000000000000000000000..60fccc695e48bc2dba7c93a021ed18245a026016
--- /dev/null
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+
+--- Page 1 ---
+UUID:ADF270C6-0B79-4040-9571-0CCDEA4F1224 TCGA-L5-A88Y-01A-PR Redacted PREVIOUS DIAGNOSIS INQUIRY REPORT nats. PAGE #: NAME: PATIENT NBR: SEX: M BIRTHDATE: ADM DATE: OPER DATE: ACCESSION: REQ DOC: PROCEDURE: VERIFIED: By: -year-old white male syncope episode and cause accident; had scape. A positive esophageal cancer. Operative Procedure/Tissue Submitted: Transhiatal esophagectomy. PROCEDURE: VERIFIED BY: 1. "Cervical esophageal margin." Received in formalin in a small container is a 2 x 2 x 2 cm segment of esophagus with a staple line at one end. Deep inked black. 1A. Esophageal cervical margin. 18&1c. Remainder of specimen. Staple line retained.. 2. "Thoracic esophagus." Received in formalin in a large container is an 8 cm esophagus with 6 cm stomach, with a 4.2 x 3.8 x 1.0 cm exophytic plaque with rolled edges arising from the distal esophagus. The mass involves approximately half of the esophagus diameter, abuts the gastroesophageal junction, and does not appear to extend into the stomach. The mass extends to 4.5 cm from the esophageal resection edge and 4.5 cm from the gastric. resection edge. It extends through the mucosa to superticially involve the submucosa and extends to 0.6 cm of the deep resection margin. No muscularis propria involvement. The remainder of the gE junction has focal nodularity,. and the remaining mucosa of the esophagus of the stomach is unremarkable. 2A. Mass. 28-2G. Mass at deepest invasion. 2H. Nodular gastroesophageal junction. 21. Unremarkable gastroesophageal junction, bisected. 2J. Unremarkable cervical esophagus.. 2K&2L. Multiple possible lymph nodes. 2M.  One possible lymph node. 3. #Gallbladder." Received in formalin in a medium container is a 12 x 5 x 5 cm distended gallbladder with 0.3 cm patent cystic duct and containing four bosselated yellow stones, 1.0 cm each. The mucosa is green,smooth, and. diffusely thinned.. 3A. Fundus and body with cystic duct.. PROCEDURE: VERIFIED BY: ESOPHAGEAL, CARDIAC AND GASTROESOPHAGEAL JUNCTION CARCINOMA: ID0-3 Type of carcinoma: Adenocarcinoma Sute : Orotaltud yewephegus C95.5
+
+--- Page 2 ---
+PREVIOUS DIAGNOSIS INQUIRY REPORt nate. PAGE #: 2 NAME: PATIENT NBR: SEX: M BIRTHDATE: ADM DATE: ACCESSION: OPER DATE: REQ DOC: If adenocarcinoma, it is arising in: Barrett's mucosa Depth of invasion: Submucosa Number of positive lymph nodes: 0/10 Extranodal metastasis: Unknown. Pattern of invasion: Expansile Esophageal and gastric resection margins involved: No. Deep resection margin involved: No TNM classification: T1 NO MX PROCEDURE: VERIFIED BY: 1 and 2. Esophagus, resection: Invasive adenocarcinona, arising in Barrett's mucosa, extending into the mid submucosa. Margins free. Ten lymph nodes negative for carcinoma. See template.. 3. Gallbladder, resection: Cholelithiasis.. I, .the signing staff pathologist, have personaily. examned and interpreted the slides from this case.. Code: ** END OF PREVIOUS DIAGNOSIS INQUIRY **
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diff --git a/output/text/3dede6f4-668e-4678-b80c-5aa036180fe6.txt b/output/text/3dede6f4-668e-4678-b80c-5aa036180fe6.txt
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index 0000000000000000000000000000000000000000..742d23e6e167ac93a7eaa961e1745e2c9946a35c
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+UUID:041580F0-700A-4A47-83A6-207ED267E844 TCGA-A2-A4S1-01A-Pr Redacted Name Age/Sex .**Location: 'F Unit# Status Room/Bed Disch AttDr M.D This Specimen: Received: Status: Req#: Collected: Sp type: SURGICAL P Subm Dr: ,M.D. PREOPERATIVE DIAGNOSIS 174-RT BREAST CANCER-INVASIVE OPERATION PERFORMED DATE : DOCTOR(S) : PROCEDURE: MASTECTOMY PARTIAL LUMPECTOMY, ULTRASONIC NEEDLE LOC BREAST BX PROCEDURE (CONT):BX SENTINEL NODE TISSUE REMOVED A. RT PARTIAL MASTECTOMY POSSIBLE SARCOMA SHORT STITCH SUPERIOR MEDIAL SKIN MARGIN LONG STITCH LATERAL SKIN MARGIN @ B. RT BREAST MEDIAL MARGIN AT 1es-0-3 C.  RT BREAST SUPERIOR MARGIN @ carciona, Metaplesh'c, NOs D. RT BREAST LATERAL MARGIN @ E. RT BREAST INFERIOR MARGIN AT 85 75f3 F. RT BREAST POSTERIOR MARGIN @ Srtw : bust, Nos RT BREAST ANTERIOR MARGIN @ c 50.9 RT BREAST MEDIAL POSTERIOR MARGIN @ I. RT AXILLARY SENTINEL NODE HOT AND BLUE COUNT 241 @ 10/2u/1s GROSS CESCRIPTION RECEIVED IN 9 PARTS. RECEIVED LABELED RIGHT BREAST PARTIAL MASTECTOMY A POSSIBLE SARCOMA SHORT SUPERIOR MEDIAL SKIN MARGIN LONG LATERAL SKIN MARGIN IS A 167 GRAMS PARTIAL MASTECTOMY WITH A 10 X 4.5 CM SKIN ELLIPSE.  ON THE LATERAL PORTION OF THE SPECIMEN THERE ARE SEVERAL ELEVATED SLIGHTLY DARKENED SKIN LESIONS THE LARGEST O.5 X O.4 CM. ONE OF THESE IS GROSSLY FOUND TO BE A SUPERIOR LATERAL SKIN MARGIN. THERE IS A PROMINENT PALPABLE MASS WITHIN THE SPECIMEN.  THE MARGINS ARE MARKED AS FOLLOWS USING SKIN AS THE ANTERIOR MARGIN: LATERAL ORANGE, MEDIAL RED, INFERIOR BLUE, SUPERIOR GREEN, POSTERIOR BLACK. RED-BROWN MUSCLE FIBERS ARE NOTED IN THE AREA OF THE MASS ON THE POSTERIOR ASPECT WHICH OTHERWISE.HAS A SMOOTH APPEARANCE. SECTIONING REVEALS A DISCRETE
+
+--- Page 2 ---
+Patient: Spec Received: Status: Req#: cinen: Collected: Sp type: SURGICAL P Subm Dr: GROSS DESCRIPTION (Continued) FIRM GRAY MASS MEASURING 3.4 X 2.8 X 2.8 CM. CENTRALLY THERE IS RED DISCOLORATION TO THE NODULE AND ANTERIOR INFERIORLY TO THIS THERE IS A 1.3 CM IN DIAMETER AREA OF RED-BROWN BLOOD.  THE DEEP MEMBRANOUS SURFACE EASILY SLIDES OVER THIS MASS WHICH IS ONLY COVERED GROSSLY BY THE DEEP FASCIA AND MUSCLE FIBERS. IT IS OTHERWISE GREATER THAN 1 CM FROM ALL MARGINS.....SECTIONS.. ARE..SUBMITTED..AS... EOLLOWS.....A....REPRESENTATIVE... PERPENDICULAR MEDIAL MARGIN, A2--REPRESENTATIVE PERPENDICULAR LATERAL MARGIN, A3 THROUGH A9--FULL CROSS SECTION OF THE LESION TO INCLUDE THE DEEP MARGIN (A3) AND THE ADJACENT HEMORRHAGIC AREA (A5), A6--OVERLYING SKIN TO THIS NODULE, AND REPRESENTATIVE SKIN LESION, A7--REPRESENTATIVE SUPERIOR MARGIN TO THIS LESION, A8 AND A9--REPRESENTATIVE INFERIOR MARGIN TO THIS LESION, A1O--CROSS SECTION OF LESION TO INCLUDE POSTERIOR MARGIN, A11--THE HEMORRHAGIC AREA ADJACENT TO A1O, A12--LATERAL PORTION OF LESION WITH ADJACENT HEMORRHAGIC TISSUE. NOTE: RANDOM SECTIONS OF THE MASS ARE SUBMITTED PER PROTOCOL AS PI-P5 WITH MIRROR IMAGE SECTION FROZEN OF P1 AND P2 AS WELL AS RANDOM TISSUE FRESH FROZEN.  A PORTION OF SKIN IS ALSO SUBMITTED AS P6 FROM THE AREA OF SKIN IN A6. RECEIVED LABELED BREAST MEDIAL MARGIN IS A 5 X 3.9 X 1.2 CM FRAGMENT OF YELLOW FATTY TISSUE.  PURPLE-BLUE COLORATION IS NOTED ON ONE SURFACE.  THIS SURFACE IS REMARKED WITH BLUE INK WITH A PERIMETER OF BLACK. THIS IS SECTIONED AND SUBMITTED AS B1-B9. C RECEIVED LABELED RIGHT BREAST SUPERIOR MARGIN IS A 3.8 X 2.8 X 1.1 CM FRAGMENT OF YELLOW FATTY TISSUE. BLUE COLORATION IS SEEN ON ONE SIDE OF THE SPECIMEN. THIS SIDE IS REMARKED WITH BLUE INK WITH A PERIMETER OF BLACK. THIS IS SECTIONED AND SUBMITTED AS C1-C3. D RECEIVED LABELED RIGHT BREAST LATERAL MARGIN IS A 2.8 X 1.8-X O.8 CM FRAGMENT OF YELLOW FATTY TISSUE.  PURPLE-BLUE COLORATION IS SEEN ON ONE SIDE OE THE SPECIMEN. THIS IS REMARKED WITH BLUE INK WITH A PERIMETER OF BLACK. THIS IS SECTIONED AND SUBMITTED AS D1 AND D2. E RECEIVED LABELED RIGHT BREAST INFERIOR MARGIN IS A 4.5 X 2.7 X 1 CM FRAGMENT OF YELLOW FATTY TISSUE. PURPLE-BLUE COLORATION IS SEEN ON APPROXIMATELY ONE-HALF OF ONE SIDE OF THE SPECIMEN. THIS SIDE IS ENTIRELY MARKED WITH BLUE INK WITH A PERIMETER OF BLACK. THIS IS SECTIONED AND SUBMITTED LABELED E1-E3. E RECEIVED LABELED RIGHT BREAST POSTERIOR MARGIN IS AN IRREGULAR FRAGMENT OF YELLOW FATTY TISSUE WITH MULTIPLE METAL CLIPS MEASURING 4.2 X 3.7 X 0.6 CM IN GREATEST DIMENSION. PURPLE-BLUE
+
+--- Page 3 ---
+(Contin Specimen: Received: tatus: Req# Collected: Sp type: SURGICAL P Subm Dr: .D. GROSS DESCRIPTION (Continued) COLORATION IS SEEN ON ONE SIDE OF THE SPECIMEN WHICH IS THEN REMARKED WITH BLUE INK WITH A PERIMETER OF BLACK. THIS IS SECTIONED AND SUBMITTED AS F1-F3. G RECEIVED LABELED RIGHT BREAST ANTERIOR MARGIN IS AN IN GREATEST DIMENSION. PURPLE-BLUE COLORATION IS SEEN ON ONE SIDE OF THE SPECIMEN WHICH ALSO DEMONSTRATES BLUE DYE WITHIN THE TISSUE. THIS SIDE IS REMARKED WITH BLUE INK WITH A PERIMETER OF BLACK. THIS IS SECTIONED AND SUBMITTED LABELED G1-G7. H RECEIVED LABELED RIGHT BREAST MEDIAL POSTERIOR MARGIN IS A 4.2 X 3.2 X 0.5 CM FRAGMENT OF YELLOW FATTY TISSUE. BLUE COLORATION IS SEEN ON ONE SIDE OF THE SPECIMEN.  THIS SIDE IS REMARKED WITH BLUE INK WITH A PERIMETER OF BLACK. THIS IS SECTIONED AND SUBMITTED LABELED H1-H3. I  RECEIVED LABELED RIGHT AXILLARY SENTINEL NODE HOT AND BLUE COUNT 241 IS A 5  X 1.5 CM FRAGMENT OF YELLOW FATTY TISSUE. X3.5X EXAMINATION REVEALS 2 NODAL STRUCTURES. ONE IS 4.0 X O.8 X 0.4 CM. THIS IS SECTIONED INTO MULTIPLE PIECES AND SUBMITTED AS II AND 2. THE 2ND MEASURES O.6 X 0.4 X 0.2 CM.  THIS IS SUBMITTED LABELED I3. COMMENT: THIS CASE IS IN COMPLIANCE WITH CAP GUIDELINES OF 6-48 HOURS FORMALIN FIXATION TIME. PROCEDURES : 88307/9, IMMUNOPEROXIDAS/2, A BLK/12, B BLK/9, C BLK/3, D BLK/2, E BLK/3, F BLK/3, G BLK/7, H BLK/3, IBX X6/3 FINAL DIAGNOSIS PART A RIGHT BREAST, PARTIAL MASTECTOMY: .htc cA Metopkste POORLY DIFFERENTIATED MALIGNANT NEOPLASM WITH OSTEOSARCOMATOUS 33|3 FEATURES WHICH MOST LIKELY REPRESENTS A METAPLASTIC CARCINOMA OF 3.4em BREAST NUCLEAR GRADE 3 WITH HIGH MITOTIC INDEX WITH FOCI OF MALIGNANT OSTEOID FORMATION. oste oid tormaton Omarzins BxD Oskin
+
+--- Page 4 ---
+Req# : Spec Received: Status: Collected: Sp type: SURGICAL P Subm Dr: M.D. EINAL DIAGNOSIS (Continued) ADJACENT BREAST TISSUE WITH FOCI OF INTERMEDIATE TO HIGH GRADE 2. DUCTAL CARCINOMA IN SITU OF SOLID AND CRIBRIFORM TYPE WITH FOCI OF Sold INTRADUCTAL NECROSIS AND CALCIFICATION. Cr1b 3. THE INVASIVE NEOPLASM MEASURES 34 MM IN GREATEST DIMENSION AND IS nec Catr PRESENT...2..MM...EROM THE.POSTERIOR.MARGIN..AND..S.MM..OR.GREATER..EROM.ALL OTHER MARGINS. 4 THE LARGEST FOCUS OF DCIS MEASURES 1O MM IN GREATEST DIMENSION. DCIS IS PRESENT 1 MM FROM THE INEERIOR MARGIN, 2 MM FROM THE LATERAL MARGIN AND 5 MM OR GREATER FROM ALL OTHER MARGINS.S 5. LYMPHATIC INVASION IS NOT IDENTIFIED.S 6. BIOPSY SITE CHANGE WITH REACTIVE FIBROSIS AND FAT NECROSIS. 7. SEGMENT OF BENIGN SKIN. Fcc ADH PART B RIGHT BREAST, MEDIAL MARGIN REEXCISION: FIBROCYSTIC DISEASE WITH A FOCUS OF ATYPICAL DUCT HYPERPLASIA, DUCT HYPERPLASIA OF THE USUAL 1Dh-2 TYPE AND SCLEROSING ADENOSIS. A FEW CALCIFICATIONS ARE PRESENT. THE SA Ca# NEW INKED MARGIN IS FREE OF NEOPLASM. PART C RIGHT BREAST, SUPERIOR MARGIN REEXCISION: INTERMEDIATE GRADE DciSg2 DUCTAL CARCINOMA IN SITU WITH EXTENSION INTO TERMINAL LOBULES WITH FOCAL INTRADUCTAL NECROSIS. DCIS IS PRESENT 3 MM FROM THE NEW INKED MARGIN. 10b ca RESIDUAL INVASIVE NEOPLASM IS NOT IDENTIFIED. THE AREA INVOLVED BY DCIS HAS A CALCULATED DIMENSION OF APPROXIMATELY 8 MM. PART D RIGHT BREAST, LATERAL MARGIN REEXCISION: LIPOMATOUS BREAST TISSUE WITH NO EVIDENCE OF RESIDUAL TUMOR. THE NEW INKED MARGIN IS FREE OF NEOPLASM. PART E RIGHT BREAST, INFERIOR MARGIN REEXCISION:S LOW GRADE DUCTAL CARCINOMA IN SITU OF CRIBRIFORM TYPE NUCLEAR GRADE 1 WITH LOW MITOTIC Imm mak INDEX MEASURING 4 MM IN GREATEST DIMENSION. DCIS IS PRESENT 2 MM FROM THE NEW INKED MARGIN. RESIDUAL INVASIVE TUMOR IS NOT IDENTIFIED.S Cri b PART F RIGHT BREAST, POSTERIOR MARGIN REEXCISION:S  LIPOMATOUS TISSUE WITH NO EVIDENCE OF RESIDUAL NEOPLASM.  THE NEW INKED MARGIN IS FREE OF (  NEOPLASM. PART G RIGHT BREAST, ANTERIOR MARGIN REEXCISION: NO EVIDENCE OF RESIDUAL NEOPLASM. THE NEW INKED MARGIN IS FREE OF NEOPLASM.
+
+--- Page 5 ---
+Patient: (Continued) en: Status: Req# Collected: Sp type: SURGICAL P Subm Dr: EINAL DIAGNOSIS. (Continued) PROLIFERATIVE FIBROCYSTIC DISEASE WITH NUMEROUS CALCIFICATIONS PRESENT. FCc Ca# PART H RIGHT BREAST, MEDIAL POSTERIOR MARGIN REEXCISION: LIPOMATOUS TISSUE AND SKELETAL MUSCLE WITH NO EVIDENCE OF RESIDUAL NEOPLASM. THE NEW INKED MARGIN IS FREE OF NEOPLASM. PART I  RIGHT SENTINEL NODE, BIOPSY: LYMPH NODE (I), NEGATIVE FOR TUMOR BY STEP SECTION AND CYTOKERATIN STAIN. COMV MULTIPLE BLOCKS OF THE INVASIVE NEOPLASM ARE STAINED WITH CYTOKERATIN STAIN AND DEMONSTRATE VIRTUALLY NO STAINING OF THE INVASIVE TUMOR ALTHOUGH FOCI OF ADJACENT DCIS DO DEMONSTRATE STAINING. THIS TUMOR IS MOST LIKELY A METAPLASTIC CARCINOMA OF BREAST DUE TO THE ASSOCIATION WITH DUCTAL CARCINOMA IN SITU. Signed Electronically signed by:_ M.D.
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diff --git a/output/text/3e1f0a3b-b606-45fd-adfa-020897bf0c82.txt b/output/text/3e1f0a3b-b606-45fd-adfa-020897bf0c82.txt
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+fo/9rf#t UUID:BEC7EEA9-6DEA-4402-A3A1-07EF33D58174 Redacted 1cs-0-3 csrcnoma, aslenoid eyshc 82oo/3 Sif : susst, No5 c50.7 Ta. Final Pathologic Diagnosis: A. Sentinel lymph node #1, biopsy: No carcinoma in one lymph node (0/1); see comment. B. Sentinel lymph node #2, biopsy: No carcinoma in one lymph node (0/1); see comment. C. Breast, left, wire-guided partial mastectomy: 1. Adenoid cystic carcinoma, SBR Grade 1, 1.2 cm; see comment. 2. Microcalcifications involving benign ducts. 3. Atypical ductal hyperplasia. 4. Apocrine metaplasia. 5. Biopsy site changes. 6. Fibroadenoma. D. Breast, right, mammoplasty: 1. Intraductal papilloma. 2. Sclerosing adenosis. 3. Apocrine metaplasia. 4. Microcalcifications involving benign glands. 5. Microcysts. Page I of 6
+
+--- Page 2 ---
+Surgical Pathology - Working Draft 6. Skin with no significant pathologic abnormality. 7. No carcinoma identified. E. Breast, left, mammoplasty: 1. Usual ductal hyperplasia. 2. Apocrine metaplasia. 3. Fibroadenoma.e 4. Skin with no significant pathologic abnormality.. S. No carcinoma identified. Note: This is an unusual tumor. H&E sections show a relatively circumscribed tumor with large nests of epithelial cells in a cribriform growth pattern. The stroma is sclerotic. The differential diagnosls. includes adenoid cystic carcinoma or a cribriform varlant of invasive ductal carcinoma. A prlor core needle biopsy of the left breast at 6 o'clock (. ) was reviewed. Immunohistochemical studies were necessary to evaluate this case and establish the correct diagnosis. The following immunohistochemical stains were performed and evaluated: ER: Positive, 2+ staining in 75% of cells. PR: Negative, no staining in any tumor cells. (internat positive control present) CD117: Positive. SMA: Focally positive, relatively high background.. SMm: No myoepithelial cells present around most nests of tumor cells. p63: Positive in basaloid celis in most areas. The above immunohistochemical stains support a diagnosis if adenoid cystic carcinoma. Although ER expression is often negative in adenoid cystic carcinoma, the presence of basal cell immunophenotype (positive p63) and the positlve CD117 support this diagnosis. Insofar as adenold cystic carcinoma represents a dual population of basalold and epithelial cells, it may be that this exanple is somewhat rich in the epithelial component thus explaining the ER positivity. The above interpretation may also explain the rather diffuse CD117 stainlng. The absence of a define myoepitheliat layer by the SMM further supports the diagnosis. We recognize that this tumor was also sent for gene expression. profiling so correlation with those findings for a basaloid expression proflle is also suggested. Drs.  have reviewed selected stides form this case and concur wlth the diagnosis of adenoid cystic carcinoma.. Breast Tumor Synoptic Comment - Laterality: Left. - Invaslve tumor type: Adenoid cystic carcinoma.. - Invasive tumor size: 1.2 cm. - Invasive tumor grade (modified Bloom-Richardson):. Nuclear grade: 2. Mitotic count: 1 mitotic figures/10 HPF. Tubule/papilla formation: 1. Tota! points and overall grade = 4 points = grade 1.. - Lymphatic-vascular invasion: None. - Skin/nipple: No speclfic pathoiogic abnormalities. - Margins for invasive tumor: Negative.  Anterior (skin): N/A. - Posterior: Negative (tumor is > 1 cm away). - Inferlor lateral margin (black ink): Negative; (tumor is >1 cm away, on stide C4). - Inferior medial margin (green Ink): Negative; (tumor is > 1 cm away, on slide C5). - Superior margin (blue Ink): Negative; (tumor is >1 cm away, on siide C3). - Microcalcifications: Present, involving benign ducts.. Paae 2 of 6d
+
+--- Page 3 ---
+Surgical Pathology -. Working Draft - Lobular carcinoma In situ: None.. - Lymph node status: Negative.. - Tota! number sampled: 2. - AJCC/UICC stage: pT1cNOMX. Result of HER2/neu test: This carcinoma is negative for HER2/neu oncoprotein over-expression.. An immunohistochemical assay was performed by manual morphometry on block C3 using the CB11 monoclonal antibody to HER2/neu oncoprotein. The stalning Intensity of this carcinoma was 0 on a scale of 0-3. Carcinomas with stalning intensity scores of 0 or 1 are considered negative for over-expression of HER2/neu oncoprotein. Those with a sta!ning intensity score of 2 are considered indeterminate. We and others have observed that many carcinomas with staining intenslty scores of 2 do not show gene amplification. All carcinomas with staining intensity scores of 2 are therefore Submitted for FiSh testing. The results of the FIsh test are Issued directly from the molecular cytogenetics laboratory. Carcinomas with staining intensity scores of 3 are considered positive for over-expression of HER2/neu oncoprotein. Tumors in this category show an excellent correlation between the results of immunohlstochemical and FIsh testing, and almost always show gene amplificatlon.  In addition to the above findings, several lymph nodes are enlarged with a fairly monotonous population of small lymphocytes, concerning for lymphoma. Immunohistochemical stains were performed to characterize the small lymphocyte population as follows: - CD20: Highlights widely scattered aggregates of small lymphoid cells, consistent with primary follicles. - CD3: Highlights small lymphocytes predominantly in interfollicular areas. - CD21: Highlights aggregates of dendritic cells underlying B cell aggregates, confirming their identity as B cell follicles. - CD23: Highllghts aggregates of dendritic cells underlying B cell aggregates, conflrming their identity as B cell folllcies. Together, these findings are consistent with a diagnosis of benign quiescent nodes, and argue against a diagnosis of iymphoma. Dr. of Hematopathology has reviewed parts A and B and agrees with the above Interpretation. A preliminary diagnosis was glven to in Dr.   clinic on Additional preliminary diagnosis given to. : in ur.  clinic on Intraoperative Consuit Diagnosis FS1 (A1) Sentinel lymph node #1 (half of the specimen), biopsy: Rare scattered atypical cells. Cannot completely rule out carcinoma. Defer to permanent. Dr. concurs. (Dr. FS2 (A2) Sentinel lymph node #1 (other half of the specimen), biopsy: Rare scattered atypical cells.. Cannot completelv nsle out carcinoma. Defer to permanent. Dr.  concurs. (Dr. FS3 (B) Sentinel lymph node #2, biopsy: Rare scattered atypical cells. Cannot completely rule out carcinoma. Defer to permanent. Dr. concurs. (Dr. Clinical History The patient is a  :year-oid female with adenoid cystic carcinoma of the left breast vs. ductal carcinoma. She has an additional lesion, seen on MRI, suspicious for carclnoma. The patient now. undergoes left wlre-guided partia! mastectomy and sentinel lymph node dissection with bilateral mammoplasty for symmetry.. Gross Description Page 3 of 6
+
+--- Page 4 ---
+Surgical Pathology - Working Draft The specimen is received in five parts, each labeled with the patient's name and unit nuruer. rarts A-C are received fresh. Parts D-E are received in formalin. Part A, additionally labeled "1 - sentinel lymph node #1 count = 590o," consists of one soft, ovoid, red-yellow, irregular, unoriented fibroadipose tissue fragment that is 3.2 x 2 x 1 cm. It is oriented by a stitch placed by the surgeon marking the hottest spot. The stitch area is inked blue. Adipose tissue is removed. Lymph node candidate is bisected. so% of the lymph node candidate is submitted for frozen section diagnosis 1, with the frozen section remnant submitted in cassette A1. The remaining 50% of the lymph node candidate is submitted for frozen section diagnosis 2, with the frozen section remnant submitted in cassette A2. The remaining adipose tissue is submltted in cassette A3. Part B, additionally labeled "2 - sentinel lymph node #2 count = 12700,* consists of one soft, red-yellow, irregular, unoriented, ovoid, orlented fibroadipose tissue fragment that is 2 x 1.7 x 0.8 cm. A stitch is placed by the surgeon marking the hottest spot; this area is inked blue. Adipose tissue Is removed. The lymph node candidate is bisected and submitted for frozen section diagnosis 3, with the frozen section remnant submitted in cassette B1. The remaining adipose tissue is submitted in cassette 82. Part C is labeled "left breast needle localization biopsy." - SPEcrmeN TyPE: Wire-guided partial mastectomy. - Skin ellipse: Present. - NIpple: Not present. - ORIENTATION: - Double long suture: Lateral, on side with Telfa. - Short double suture: Superior. - Short single suture: Inferior, opposite of needle wire. - INKING (for microscopic evaluation): - Black: Lateral (Telfa side).. - Green: Medial (side opposite wire needle). - Blue: Superior (side with wire). - SIze Of Specimen: - Medial-lateral dimension: 6 cm.. - Superior-inferior dimension: 6 cm.. - Anterior-posterior dimension: 11.2 cm. - total number of slices: 19.. - First slice (sllce 1): Anterior margin (skin).. - Last slice (slice 19): Posterior margin..  GRoss PAthOlOgy: On serial sectioning, multiple nodules are Identified throughout the breast parenchyma. A domInant, rubbery/hard, tan-pink mass is Identified in slices 3-4 and measures 1 x 1. x 0.8 cm. This mass is located centrally within the slices and is located 1.1 cm from the blue ink, 1 cm from the green ink, and 1.5 cm from the black ink. Two tan-white rubbery nodules are seen in slice 5; one nodule measures 0.7 x 0.4 x 0.3 cm and Is 0.7 cm from the blue ink. The other nodule measures 0.3 x 0.3 x 0.3 cm and is 0.2 cm from the blue ink. A tan-yellow rubbery nodute Is. identified In slice 7-8, measuring 0.4 x 0.3 x 0.3 cm. In addition, a white-tan rubbery nodular area is seen in slice 8, abutting the black ink and measuring 0.6 x 0.3 x 0.2 cm. A white-tan rubbery nodule is also seen in sllce 9, abutting the blue ink, and measuring 0.3 x 0.2 x 0.2 cm. An additlonal hard, tan-plnk nodule is seen in slice 9, measuring 0.3 x 0.3 x 0.3 cm. A tan-white rubbery nodule is seen in slices 15-16, measuring 0.5 x 0.5 x 0.5 cm. This nodule is suspicious for a lymph node. The needle tip is present in slice 15. Representative sections are submitted as follows: Cassette C1: Skin (slice 1). Cassettes C2-C5: Dominant mass in slices 3-4, entirely submitted. Cassette C6: Larger nodule, slice 5. Cassette C7: Smaller nodule, slice 5. Cassette C8: Nodute, slices 7-8.. Cassette C9: Nodular area in sllce 8, abutting black ink. Cassette C10: Both nodules in slice 9. Cassette C11: Nodule, slice 11. Cassettes C12-C13: Nodule, slices 15-16, entirely submitted. Paxc 4 of 6
+
+--- Page 5 ---
+Surgical Pathology - Working Draft Cassettes C14-C15: Posterior margin, perpendicularly sectioned. Part D, labeled "right breast tissue and skin," consists of one fragment of fibrofatty tissue with attached skin and muitiple other fragments of skin and fibrofatty tissue measuring, in aggregate, 13 x 10 x 3.5 cm and weighing 170 gm in total. The fragments of skin are grossly unremarkable, with no suspicious lesions or areas. A single tan-yellow nodule measuring 0.1 x 0.1 x 0.1 cm is noted In one of the fibrofatty tissue fragments, which also contains an area that is mostly fibrous. The largest. fibrofatty tissue fragment with attached skin, measuring 11.5 x 9.2 x 3.5 cm and the skin eilipse measuring 8 x 7 cm, contains a slngle white-tan, rubbery, nodular area measuring 0.3 x 0.2 x 0.2 cm. The rest of the specimen is grossly unremarkable, with no other susplcious lesions seen.. Representative sectlons are submitted as follows: Cassette D1: 0.1 x 0.1 x 0.1 cm nodule from fibrofatty tissue fragment. Cassette D2: Fibrous area from fibrofatty tissue fragment.. Cassette D3: Nodular area from largest specimen.. Cassette D4: Representative section skin and fibrofatty tissue from largest specimen.. Part E, labeled "left breast tissue and skin," consists of multiple fragments of fibrofatty tissue, as well as multiple fragments of skin, in aggregate measuring 6.5 x 6.5 x 2.2 cm and weighing 154 gm in total. The skin fragments are grossty unremarkable, with no suspicious areas or lesions seen. One fibrofatty tissue fragment contains a tan-white, lobulated, rubbery, nodular area measuring 1.2 x 1.1 x 1 cm. The rest of the fibrofatty tissue fragments are grossly unremarkable, with no suspicious lesions or areas seen. Representative sections are submitted as follows: Cassette E1: Representative section of skin.. Cassettes E2-e3: Nodule in flbrofatty tissue fragment, entirely submitted. Cassette E4: Representative sectlon of fibrofatty tissue.. /Pathology Resident /Pathologist Signed: Fee Codes: Other Specimens Specimen Class: : Status: Signed Out Accessioned: Signed Out: Specimen(s) Recelved: Consult, Surgical w/ blocks or tissue Final Diagnosis Review of from  Left breast, 6 o'clock, core needle biopsy: Malignant neoplasm with cribriform growth. pattern; see comment. MD MD -Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Reccived: Left Breast, Fine Needle Aspiration. Final Diagnosis Left Breast, Fine Needle Aspiration: Fibroadipose tissue, see comment.. Page S of 6
+
+--- Page 6 ---
+Surgica! Pathology Working Draft ...Spccimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Left breast, needle core biopsy 5:00, Scm from nipple Final Diagnosis Left breast, 5:00, 5 cm from nipple, needle core biopsy: 1. Fibroadenoma with microcalcifications see comment. 2.Fat necrosis. END OF REPORT Page 6 of 6
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+Ics -0 - 3 Carcin ornc, nfi(trsthg dductal, Nos 85os/z Si#, brsot Nos c5o.9 1/2.5 Diagnosis: 1. Breast segment with a poorly differentiated invasive ductal carcinoma (tumor diameter: 3 cm) with a focal intraductal component.. Tumor classification: NOS, G II, pT2L0V0R0 UUID:5A6E0F10-758E-4DC1-A5C7-57D50F9825EF Redacted
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+
+--- Page 1 ---
+UUID:7204DF29-2167-48A0-AA56-51E9AFFBB0D5 TCGA-IR-A3LH-01A-PR Redacted Specimens Submitted: 1: sP: Right periaortic lymph node (fs) 2: SP:  Left para-aortic lymph nodes (fs) 3: SP: Posterior vaginal margin (fs). 4: SP: Radical hysterectomy with bilateral tubes and ovaries (fs) 5: SP: Right  external iliac lymph node. 6: SP: Right external iliac lymph node, lateral 7: SP: Right common iliac lymph node ( 8: Sp: Right obturator lymph node 9: Sp: Right hypogastric lymph node 10: Sp:  Left external iliac iymph nodes :. 11: Sp: Left common iliac lymph node 12: Sp: Left  obturator lymph node 13: SP: Left hypogastric lymph nod6o /cD-0-3 14: SP: Left parametrium c 53.9 DIAGNOSIS: Site: cerix, Nos. lw 1) LYMPH NODES, RIGHT PERIAORTIC; EXCISION: 12/20/ - TWO BENIGN LYMPH NODES (O/2). - ENDOSALPINGIOSIS INVOLVES ONE LYMPH NODE. 2) LYMPH NODE, LEFT PARA-AORTIC; EXCISION: - ONE BENIGN LYMPH NODE WITH ENDOSALPINGOSIS (O/1). 3) VAGINA, POSTERIOR MARGIN; EXCISION: - INVASIVE SQUAMOUS CELL CARCINOMA, POORLY DIFFERENTIATED. - ULCER IS PRESENT IN PROXIMAL PORTIONS OF THIS TISSUE.  THE TUMOR IS PRESENT AT THE LEFT LATERAL DISTAL MARGIN. NOTE:  WE CONFIRM THAT THE MARGIN SAMPLED AT THE TIME OF FROZEN SECTION WAS BENIGN. WAS CONTACTED ABOUT THIS BY EMAIL ON 4) UTERUS, CERVIX, BILATERAL OVARIES AND TUBES, BILATERAL PARAMETRIUM: RADICAL HYSTERECTOMY  AND BILATERAL SALPINGO-OOPHORECTOMY: - INVASIVE SQUAMOUS CELL CARCINOMA OF UTERINE CERVIX, POORLY DIFFERENTIATED/UNDIFFERENTIATED.  Continued on next page. nary Tunior Site HIPAA Discrepancy Case ir (circle: /x/aa/n
+
+--- Page 2 ---
+- TUMOR THICKNESS IS 8 MM OUT OF 12 MM. - NO EVIDENCE OF TUMOR MULTICENTRICITY IS IDENTIFIED. - IN SITU CARCINOMA IS ALSO PRESENT. - NO VASCULAR INVASION IS IDENTIFIED. - NO PERINEURAL INVASION IS IDENTIFIED. - VAGINAL EXTENSION IS PRESENT (SEE NOTE). - NO PARAMETRIAL INVOLVEMENT IS IDENTIFIED. - ALL SURGICAL MARGINS ARE FREE OF TUMOR. THEE ENDOMETRIUM IS UNREMARKABLE. - THE MYOMETRIUM SHOWS THE FOLLOWING ABNORMALITY: ADENOMYOSIS.  THE RIGHT OVARY SHOWS SEROUS CYSTADENOMA. - ALL OTHER ADNEXAE ARE UNREMARKABLE. - THE LYMPH NODE STATUS IS AS FOLLOWS (EXPRESSED AS THE NUMBER OF METASTATIC NODES IN RELATION TO THE TOTAL NUMBER OF NODES EXAMINED) : BENIGN RIGHT PARAMETRIAL LYMPH NODES (O/7). SEVEN  INCIDENTAL ADRENAL REST AND OCCLUDED BLOOD VESSELS IDENTIFIED IN RIGHT PARAMETRIUM.S NOTE:  THE POSTERIOR VAGINAL CUFF MARGIN OF THIS STPECIMEN IS EXTENSIVELY ULCERATED AND INFLAMED. ALTHOUGH DEFINITE INVASIVE CARCINOMA IS NOT IDENTIFIED DISTALLY IN THIS SPECIMEN, WE NOTE THAT INVASIVE CARCINOMA IS PRESENT IN THE ADDITIONAL POSTERIOR MARGIN (PART 3). 5) LYMPH NODES, RIGHT EXTERNAL ILIAC; EXCISION: - SIX BENIGN LYMPH NODES (0/6). 6) LYMPH NODES, RIGHT EXTERNAL ILIAC, LATERAL; EXCISION: -THREE BENIGN LYMPH NODES (O/3). 7) LYMPH NODES, RIGHT COMMON ILIAC; EXCISION: THREE BENIGN LYMPH NODES (O/3). 8) LYMPH NODES, RIGHT OBTURATOR; EXCISION: TWO BENIGN LYMPH NODES (O/2). 9) LYMPH NODE, RIGHT HYPOGASTRIC; EXCISION: - ONE BENIGN LYMPH NODE (O/1). 10) LYMPH NODES, LEFT EXTERNAL ILIAC; EXCISION: FIVE BENIGN LYMPH NODES (O/5). 11) LYMPH NODES, LEFT COMMON ILIAC; EXCISION: TWO BENIGN LYMPH NODES (0/2). 12) LYMPH NODES, LEFT OBTURATOR; EXCISION: - SIX BENIGN LYMPH NODES (0/6). - ENDOSALPINGIOSIS INVOLVING ONE LYMPH NODE. 13) LYMPH NODE, LEFT HYPOGASTRIC; EXCISION: - ONE BENIGN LYMPH NODE (O/1). 14) PARAMETRIUM, LEFT; EXCISION: - BENIGN FIBROCONNECTIVE TISSUE. - ONE BENIGN LYMPH NODE (O/1). ** Continued on next page
+
+--- Page 3 ---
+I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL). AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT.
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diff --git a/output/text/3e331e6c-3f68-410f-89fa-4db0f9ef6555.txt b/output/text/3e331e6c-3f68-410f-89fa-4db0f9ef6555.txt
new file mode 100644
index 0000000000000000000000000000000000000000..956918535fa13514ba7ef674e69a1a3f0a0544fe
--- /dev/null
+++ b/output/text/3e331e6c-3f68-410f-89fa-4db0f9ef6555.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+This is an invasive, poorly differentiated adenocarcinoma of the colon (according to clinica. findings the descending colon) with penetration of all the parietal layers and vascular infiltrates (pT3, L1, V1) with six lymph node metastases (6/14). Tumor classification: ICDO-DA-M 8140/3 G3 pT3 L1, V1, pN2 (6/14)
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diff --git a/output/text/3e393e97-49bc-4ef7-a622-e08d21391962.txt b/output/text/3e393e97-49bc-4ef7-a622-e08d21391962.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0fe87b05c5b4fe22d510c6496cedf705a2a736f8
--- /dev/null
+++ b/output/text/3e393e97-49bc-4ef7-a622-e08d21391962.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SPECIMEN A. Apical lymph node B. Extended right hemi-colectomy. CLINICAL NOTES PRE-OP DIAGNOSIS: Colon cancer GROSS DESCRIPTION A. Received in formalin labeled "apical lymph node" is an 0.6 cm. in greatest dimension soft tan lymph node. It is bisected. AS-1. B. Received fresh in a container labeled "extended right hemi-colectomy" is a previously unopened portion of bowel, consisting of 8 cm. of distal ileum with 25 cm. of contiguous right colon. The serosal surface is smooth to slightly scabrous tan- pink, with a moderate amount of attached omentum and mesenteric adipose tissue. There is an appendix present, 6.4 cm. long, and averaging 0.8 cm. in diameter. The appendix has a tan serosa, tan wall and mucosa, and is without focal lesion, and without gross evidence of inflammation. The bowel measures 3.6 cm. and 5.2 cm. in circumference at the proximal and distal resection margins respectively. The bowel is opened. There is a 4.5 x 4.2 cm. circumscribed rubbery tan-pink-red tumor 11 cm. from the distal margin. On cut surface, it is maximally 1 cm. thick and extends through the muscularis propria and into the surrounding adipose tissue. It is approximately 1.5 cm. from the outer surface of the specimen.  Per the clinical request, tumor and normal mucosa are submitted for tissue procurement. The remainder of the mucosa is unremarkable and tan, with a normal pattern of folds, including in the ileum and the remainder of the colon. The wall of the ileum averages 0.4 cm. thick, and of the colon 0.5 cm. thick. The adipose tissue is dissected, and multiple soft tan lymph nodes measuring up to 0.9 cm. in greatest dimension are identified. RS-15, according to the accompanying block summary, following fixation. BLOcK suMMARy: B1 - proximal and distal resection margins; B2-B6 - tumor, with B2 & B3 together forming a composite full thickness section to outer surface of the specimen, with point of continuity between blocks inked orange; B7 - Icv; B8 - random colon; B9 - appendix; B10-B15 - lymph nodes, with multiple lymph nodes per block, except block B15 which contains one bisected lymph node.
+
+--- Page 2 ---
+MICROSCOPIC DESCRIPTION The following template summarizes the findings in this case: Histologic type: Adenocarcinoma, comprising the mass lesion in the colon in part B. Histologic grade: Moderately to focally poorly differentiated. Primary tumor (pT): pT3.  Carcinoma invades through the full thickness of the bowel wall and into the surrounding soft tissue. Proximal margin: Negative Distal margin: Negative Circumferential (radial) margin: Negative Distance of tumor from closest margin: See gross description Vascular invasion: Not definitively identified Regional lymph nodes (pN): pNl. There is one lymph node with metastatic carcinoma, with this lymph node identified in block B5,. a section of the main tumor, with this lymph node in surrounding adipose tissue, with much of this lymph node replaced by tumor All other lymph nodes are negative for tumor. Overall, in part B there is metastatic carcinoma in one of forty-two (1/42) lymph nodes. The separately submitted apical lymph node in part A is negative for tumor. Non-lymph node pericolonic tumor: Not identified Distant metastasis (pM): pMX Other findings:  The appendix is without specific diagnostic abnormalities. 3,5 DIAGNOSIS A. Lymph node, apical, excision  Negative for malignancy. B. Terminal ileum, appendix, and extended right colon, excision.  Moderately to focally poorly differentiated adenocarcinoma of the colon, invading through the full thickness of the muscularis propria and into surrounding soft tissue (see microscopic description).  Metastatic adenocarcinoma in one of forty-two (1/42) lymph nodes. Margins negative for malignancy. Appendix without specific diagnostic abnormalities. - End Of Report --
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diff --git a/output/text/3eaefd23-1abc-4ff3-af1e-a952b3dcac6c.txt b/output/text/3eaefd23-1abc-4ff3-af1e-a952b3dcac6c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f6854542790294ba3fed151fe00f6ff983064bfd
--- /dev/null
+++ b/output/text/3eaefd23-1abc-4ff3-af1e-a952b3dcac6c.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+pridtect UUID:859216F2-7133-4F06-B65E-380D3F22F4ED TCGA-VD-A8K8-01A-PR Redacted Page 1 of 4 REPORT Tel: Clinical Consultant & Locatlon  Forenan Sex Unit No This Copy For: SPECIMEN z&D-O3 Enucleated left eye : Mslanoina, epitheliis A rpndl wll miyee! CLINICAL DETAILS 87703 Suspected choroidal melanoma. MACROSCOPIC DESCRIPTION 9J 1/7/14 A left eye. Dimensions: Axial 24mm, Horizontal 23mm, Vertical 23mm Cornea: Horizontal 12mm, Vertical 12mm. Description: clear Optic nerve Length 12mm, Diameter 4mm Anterior chamber: normal depth On trans-illumination, a shadow located superiorly measuring 19 x 18mm. Plane of section: vertical Intraocular description: On opening he eye a large pigmented choroidal melanoma. measuring 16mm LBD x 12mm in height.. Tumour size ;BD 16mm, Height 12mm MICROSCOPY Histologically, the enucleated eye demonstrates a normal anterior chamber and open angles. The iris leaves are unremarkable. The ciliary muscles are moderately atrophic and there is moderate hyalinisation of the ciliary processes. The lens shows advanced cataractous changes. In the posterior third of the posterior segment, a choroidal Reported: Pathologist: Electronically Verifled:.
+
+--- Page 2 ---
+Department of Pathology Page 2 of 4 HISTOPATHOLOGY REPORT Tel: Surname Lab No Clinical Consultant & Locatlon Forename(s)  DOB/Age Sex Unit No Request Date This Copy For: melanoma can be seen. This is dome-shaped with a large. accompanying exudative retinal detachment. The retina overlying the tumour is atrophic with degenerative changes. The tumour is pigmented and consists of a mixture of cells, both epithelioid and spindle cells, with a dominance of the latter. The epithelioid cell component represents 15t of the tumour cell population.The melanoma cells are immunoreactive for MelanA and HSp-27 (score 2). The number of mitoses is high approx. 12/40 high power fields. The microvasculature of the melanoma is prominent, and closed loops are focally present. Occasional "yascular lakes" can be observed; in these tumour cells can be see located within the lumen. The lymphocytic infiltrate within tumour is minimal. Macrophages are scattered throughout the tumour in a moderately density.There is no evidence of scleral invasion or of extraocular growth. The optic nerve is tumour free. and demonstrates mild atrophic changes. The examined vortex veins are free of tumour. DIAGNOSIS Choroid melanoma of mixed cell type. COMMENT SPECIMEN 2= Eye TUMOUR PRESENTS Yes TUMOUR TYPE 1= Melanoma CELL TYPE 3= Mixed CT LOOPS 2- Closed loops NECROSIS No Reported Pathologist: Electronically Verified:.
+
+--- Page 3 ---
+Department of Pathology. Page 3 of 4 HISTOPATHOLOGY REPORT Tel: Surname Lab No Clinical Consuitant & Location Forename(s) DOB/Age Sex Unit No Request Date This Copy For: PIGMENTATION Yes LYMPHOCYTIC INFILTRATIONS No MITOTIC FREQUENCY 12 /40 HPF DIFFUSE MELANOMA  No SPREAD 1= No CLEARANCE 2= Adequate HSP-27 POSITIVITY 2= 21-70% LARGE DIAMETER 16 mm THICKNESS 12 mm COMMENTS : Molecular genetic examination of DNA extracted from the tumour celis will be performed using multiplex-ligation. 1. 3, 6 and 8. A supplementary report will follow as soon as these investigations are complete.. SUPPLEMENTARY REPORTS In the meantime, molecular genetic analysis of tumour DNA extracted from the fresh uveal melanoma' tissue was performed. using the technique termed multiplex ligation-dependent probe amplification (MLpa). These investigations were performed in the The kit P027 from which examines for gains or losses in 31 loci on chromosomes 1, 3, 6 and 8, was used. The DNA concentration was measured using. and the quality assessed using multiplex-pcR prior to the MLPA reaction. The DNA concentration was high and of good quality on assessment. The MLpA reaction was run at least twice on differing occasions, resulting in similar results. The results of the sequence analysis of the MLpA products is. printed on a separate report.. Reported: Pathologist: Electronically Verifled:.
+
+--- Page 4 ---
+Department of Pathology Page 4 of 4 HISTOPATHOLOGY REPORT Tel: Surnamo Lab No Clinical Consuttant & Location Forename(s)  DOB/Age Sex Unit No  Request Date This Copy For: In summary, sequence analysis demonstrated: normal chromosome 1, monosomy 3, normal chromosome 6 and gains in chromosome 8. These molecular data require correlation with the clinical and morphological data for metastatic risk assessment. Reported: Pathologist: Electronically Verified:
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diff --git a/output/text/3ec174bd-7808-4b8c-a0fe-143c3fa0c37d.txt b/output/text/3ec174bd-7808-4b8c-a0fe-143c3fa0c37d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d08bfb5bff6abe7f7743ef03cccc459b42dccb81
--- /dev/null
+++ b/output/text/3ec174bd-7808-4b8c-a0fe-143c3fa0c37d.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:351D8E38-6E04-4F54-8CB1-975AEB7D8552 TCGA-A2-A4S3-01A-PR Redacted Name Age/Sex:: /E LOCa Acet# Unit# Stat Room/Bed: Reg: Disch: Att.Dr: A.M.D. Specimen: Received: Status: Req#: Collected: Sp type: SURGICAL P Subm Dr: ., m.D.  PREOPERATIVE DIAGNOSIS  : LEFT BREAST CANCER WITH POSITIVE NODES OPERATION PERFCRMED DATE : DOCTOR(S) : PROCEDURE:  MASTECTOMY MODIFIED RADICAL/TOTAL MASTECTOMY TISSUE REMOVED Ics-0-3 Csnunrms, nifilfraHng duct;Nos 85vof3 A. RIGHT BREAST @ B. LEFT BREAST AND AXILLARY CONTENTS Sih: busst, Nos cso.9 C. HIGHEST LEFT AXILLARY LYMPH NODE 1c1>rf GROSS DESCRIPTION RECEIVED IN 3 PARTS. PART A RECEIVED LABELED RIGHT BREAST STITCH AT 12 O'CLOCK, IS A 1435.5 GRAM MASTECTOMY.  SECTIONING REVEALS THE MAJORITY OF THE SPECIMEN TO CONSIST OF BLAND YELLOW FATTY TISSUE WITH FINE FIBROUS BANDS.  CENTRALLY, THE FIBROUS BANDS BECOME BROADER BUT NO MASSES ARE IDENTIFIED.  REPRESENTATIVE SECTIONS ARE SUBMITTED AS FOLLOWS: A1--NIPPLE, A2--CENTRAL DEEP MARGIN, A3 AND 4--UPPER INNER QUADRANT, A5 AND 6--UPPER OUTER QUADRANT, A7 AND 8--LOWER OUTER QUADRANT, A9 AND 10-~LOWER INNER QUADRANT.S NOTE:  MIRROR IMAGE SECTIONS FROM THE NIPPLE AND RANDOM QUADRANT SECTIONS (Al, A3, A5, A7, AND A9) ARE SUBMITTED PER CLINICAL BREAST CARE PROJECT RESEARCH PROTOCOL, FROZEN IN PART B RECEIVED LABELED LEFT BREAST AND AXILLARY CONTENTS DOUBLE STITCH AT 12 O'CLOCK LONG STITCH AT AXILLARY CONTENTS, IS A 217O GRAM LEFT MODIFIED RADICAL MASTECTOMY SPECIMEN WHICH MEASURES 34.5 CM FROM MEDIAL TO LATERAL, 24 CM FROM SUPERIOR TO INFERIOR, AND UP TO 6.5 CM FROM ANTERIOR TO THE DEEP MARGIN. THE NIPPLE IS UNREMARKABLE WITHIN A 30 X 15 CM SKIN ELLIPSE. A SUTURE DENOTES 12 O'CLOCK.  THERE IS A MASS PALPABLE AT THE 3 O'CLOCK AND 12 O'CLOCK POSITIONS AND A MASS PALPABLE TOWARDS THE AXILLARY TAIL.  THE ANTERIOR MARGIN IS MARKED WITH BLUE INK, THE DEEP IS MARKED WITH BLACK. THE AXILLARY TAIL IS REMOVED AND WHERE IT IS CUT FROM THE MASTECTOMY SPECIMEN, THE MARGIN IS MARKED WITH RED INK
+
+--- Page 2 ---
+(Continued). Specimen: Received: Status: Req#: Collected: Sp type: SURGICAL P Subm Dr: M.D. GROSS DESCRIPTION (Continued) AND DOES NOT REPRESENT TRUE MARGIN.  IN THE LOW AXILLARY TAIL, THERE IS A 3.5 X 3.2 X 2.3 CM LYMPH NODE. A RIBBON CLIP IS IDENTIFIED. A CENTRAL CROSS-SECTION IS SUBMITTED IN B2 AND 3. SECTIONING REVEALS 4 MASSES WITHIN THE UPPER OUTER QUADRANT BETWEEN 3O0 AND 12OO. THE MOST LATERAL AT 3 O'CLOCK IS A SMALL IRREGULAR AREA MEASURING 1 X 0.8 X O.6 CM. THIS IS O5-CM-FROM-THE-DEEP-MARGIN-AND-IS-DEEP-TO THE LATERAL EDGE-OE-THE SECOND MASS GROSSLY SEPARATED BY 2 CM. THE SECOND MASS MEASURES 3.5 X 2.7 X 3.5 CM FRCM MEDIAL TO LATERAL. THE SECOND MASS IS INFERIOR TO THE THIRD AND FOURTH MASSES WHICH ARE AT 12 O'CLOCK.THE DEEPEST IS A 1.6 X 1.3 X 1 CM MASS GROSSLY 2 CM DEEP TO THE FOURTH MASS WHICH MEASURES 4 CM FROM SUPERIOR TO INFERIOR, 3 CM FROM ANTERIOR TO POSTERIOR, AND 4 CM FROM MEDIAL TO LATERAL.  THE DEEPEST OF THESE LESIONS IS 2 CM FROM THE DEEP MARGIN. THIS LAST LESION IS 1.5 CM BENEATH THE SKIN. THE REMAINING BREAST TISSUE CONSISTS OF BLAND YELLOW FATTY TISSUE. THE 2 LARGEST MASSES, ALTHOUGH GROSSLY SEPARATE, APPEAR TO ABUT EACH OTHER AND ANTERIOR TO THIS AREA IS AN ADDITIONAL O.6 CM IN DIAMETER MASS (B4). A RIBBON CLIP IS FOUND AT THE INFERIOR EDGE OF MASS 2. A COIL CLIP IS ALSO IDENTIFIED WITHIN MASS 2. SECTIONS ARE SUBMITTED AS FOLLOWS: B1--NIPPLE, B2 AND 3--LOW AXILLARY LYMPH NODE, B4--SMALL LESION ANTERIOR TO THE AREA OF THE 2 LARGER MASSES, B5--THE TISSUE ADJACENT MEDIALLY TO THE SECOND-DESCRIBED MASS AND INFERIOR TO THE FOURTH-DESCRIBED MASS, B6--DEEP MARGIN TO MASS 1 AND 2, B7--MASS 1, B8--AREA BETWEEN MASS 1 AND MASS 2, B9 AND 1O--FULL CROSS-SECTION OF MASS 2, B11--THE MOST MEDIAL EDGE OF MASS 2, B12--THE MOST LATERAL EDGE OF TUMOR 2, B13--DEEP MARGIN TO MASS 3 AND 4, B14--TISSUE BETWEEN MASS 3 AND MASS 4 WITH THE RED INK ALONG THE EDGE ADJACENT TO MASS 4, B15--MASS 3 WITH ADJACENT SMALL NODULE, B16 THROUGH 18--A LONGITUDINAL SECTION THROUGH MASS 4 FROM SUPERIOR TO INEERIOR, B19--THE MOST LATERAL AREA OF MASS 4, B2O--THE MOST MEDIAL ASPECT OF MASS 4, B21--THE ANTERIOR MARGIN TO MASS 4 SUPERIOR TO THE SKIN ELLIPSE. NOTE: SECTIONS ARE SUBMITTED FROZEN IN PER THE CLINICAL BREAST CARE PROJECT RESEARCH PROTOCOL WITH A MIRROR IMAGE OF THE NIPPLE AND RANDOM QUADRANT SECTIONS (B1 AND B22-B25).  IN ADDITION, SECTIONS OF THE LARGE LYMPH NODE #1 ARE SUBMITTED AS P1-2 WITH TISSUE ALSO FROZEN IN TISSUE FROM THE FIRST TUMOR (B7) IS SUBMITTED AS P3, OF THE SECOND TUMOR AS P4-5 AND PIO WITH TISSUE ALSO FROZEN IN  OF THE THIRD TUMOR AS P6 AND THE FOURTH TUMOR AS P7 THROUGH P9 WITH ADDITIONAL TISSUE FROZEN IN TISSUE TAKEN BETWEEN MASS 3 AND 4 (B14) IS SUBMITTED AS P11. FURTHER EXAMINATION OF THE AXILLARY TAIL REVEALS 6 ADDITIONAL LYMPH NODES, ONE OF WHICH IS GROSSLY POSITIVE. FOLLOWS: B26--GROSSLY POSITIVE NODE BISECTED, B27--1 NODE BISECTED, B28~-1 VERY SMALL NODE BISECTED, B29--2 NODES, B30 THROUGH B32--1 NODE
+
+--- Page 3 ---
+(Continued) Specimen: Received: Status: Collected: Req# : Sp type: SURGICAL P Subm Dr: M.D. : GROSS DESCRIPTION. (Continued) TOTAL, SECTIONED. PART C RECEIVED LABELED HIGHEST LEET AXILLARY NODE, ARE 4 FRAGMENTS OF YELLOW FATTY TISSUE TOGETHER MEASURING 16 X 2.8 X 1.2 CM. THIS IS EXAMINED FOR LYMPH NODES OF WHICH 6 ARE IDENTIFIED. THESE... ARE...SUBMITTED. AS..FOLLOWS.....C1---.-. NODE. SECTIONED.-- C2.--4.. NODES, C3--1 NODE BISECTED. COMMENT: THIS CASE IS IN COMPLIANCE WITH CAP/ASCO GUIDELINE OF 6-48 HOURS FORMALIN FIXATION TIME. PATH PROCEDURES: 88305, 88307, 88309, A BLK/10, B BLK/32, C BLK/3 FINAL DIAGNOSIS PART A RIGHT BREAST, MASTECTOMY:  BREAST TISSUE WITH FIBROCYSTIC CHANGE Fcc WITH DUCT HYPERPLASIA OF THE USUAL TYPE, APOCRINE METAPLASIA AND CYST 1DH-2 AM FORMATION. CALCIFICATIONS ARE PRESENT. NO EVIDENCE OF ATYPIA OR MALIGNANCY.  NIPPLE WITH HYPERKERATOSIS OF THE EPIDERMIS. Cat PART B LEFT BREAST, MODIFIED RADICAL MASTECTOMY: 1.  MULTICENTRIC IN SITU AND INFILTRATING DUCT CARCINOMAS GRADE 3 WITH 1Dc 3|2|3 x|5 NUCLEAR GRADE 2 AND HIGH MITOTIC INDEX. 2. MULTIPLE INVASIVE TUMORS ARE PRESENT MEASURING 4, 10, 12, 35 AND 40 multicentne MM IN GREATEST DIMENSION. 4cm 3.5cm l.2qm Icm 4ma 3. LYMPHATIC INVASION IS PRESENT. DLv1 4.  METASTATIC CARCINOMA TO 2 OF 7 AXILLARY LYMPH NODES. H LN 5.  THE POSTERIOR AND ANTERIOR MARGINS AND NIPPLE ARE FREE OF NEOPLASM. E marg 6. FIBROCYSTIC CHANGE. F cC PART C  HIGHEST AXILLARY LEFT LYMPH NODES: LYMPH NODES (8), NEGATIVE FOR TUMOR. 8LN
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diff --git a/output/text/3ecd83f6-3332-4cdd-b59d-4a7845b4f794.txt b/output/text/3ecd83f6-3332-4cdd-b59d-4a7845b4f794.txt
new file mode 100644
index 0000000000000000000000000000000000000000..80758050d9e668744baebcce1b5ce467eca7ff9a
--- /dev/null
+++ b/output/text/3ecd83f6-3332-4cdd-b59d-4a7845b4f794.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:A43BAAF5-711E-4BFE-BF7F-7EA157F3BEBE TCGA-R6-A8W5-01A-PR Redacted LCD O:3 ldi n&AUiu,LN6S S14cJE Juiijus,diital tuid Specimen Date/Time: ssjU@yh NO S 01S.9 rS 3|3114 DIAGNOSIS (A) ESOPHAGUS, MASS, BIOPSY: INFILTRATING, MODERATELY DIFFERENTIATED ADENOCARCINOMA, ARISING WITH DISTINCTIVE TYPE BARRETT MUCOSA WITH LOW GRADE COLUMNAR EPITHELIAL DYSPLASIA. Entire report and diagnosis completed by GROSS DESCRIPTION (A) ESOPHAGEAL MASS - Multiple tan-pink irregular fragments of tissue (0.6 x 0.2 x 0.2 cm) in aggregate. In toto in A. CLINICAL HISTORY Esophageal cancer. SNOMED CODES "Some tests reported here may have been developed and performance characteristics determined by . These tests have not been. specifically cleared or approved by the U.S. Food and Drug Administration." Released by: --END OF REPORT-- h 12/3/13 ual/Synchronous Prin 20
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diff --git a/output/text/3ef0c595-a01d-4147-85ba-eb40e0e62a77.txt b/output/text/3ef0c595-a01d-4147-85ba-eb40e0e62a77.txt
new file mode 100644
index 0000000000000000000000000000000000000000..eb1cb806c9fb538ef870014c55e025d5b32d6861
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+JcD-0 -3 adnwcarciom Mueinous 848s|3 Site: cecum c18.0 Internal Sample ID Diagnosis/Diagnoses: Right hemicolectomy specimen with an ulcerated cecal carcinoma of the histological type of a.  moderately differentiated, partially mucus-forming colorectal adenocarcinoma measuring 5.5 cm in its largest diameter and subtotally enclosing the cecum. Invasive tumor spread into all. intestinal wall layers as far as the mesocolic fatty tissue and subserosa. Colon mucosa otherwise with some tubular adenomas with moderate epithelial dysplasia (synonym: low-grade intra-. epithelial neoplasia). Oral and aboral resection margins and greater omentum tumor-free. Four of twenty-nine regional lymph nodes with metastases from the colon carcinoma. Tumor stage therefore: pT3, pN2 (4/29); G2. UUID:F373544C-93EA-40F2-9C69-1FBCE4EB31E4 TCGA-AA-A03F-01A-PR Redacted
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diff --git a/output/text/3efe5aed-4f2f-4d05-b63e-7f1e4cbd8550.txt b/output/text/3efe5aed-4f2f-4d05-b63e-7f1e4cbd8550.txt
new file mode 100644
index 0000000000000000000000000000000000000000..54f3e79f0b6b111aca3f336a0b148cb352e64568
--- /dev/null
+++ b/output/text/3efe5aed-4f2f-4d05-b63e-7f1e4cbd8550.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+ UUID: 49F4E752-EFBE-458F-85C0-188189506D91 TCGA-EP-A3RK-01A-PR  Redacted Final Surgical Pathology Report Procedure: Diagnosis Liver, left lobe, partial hepatectomy: Moderately differentiated hepatoceliular carcinoma. The margins of resection are free of carcinoma.. Microscopic Description: Histologic type: Hepatocellular carcinoma. Histologic grade: Moderately differentiated. Tumor size: Tumor measures maximally 8.7 x 7.4 x 6.0 cm Primary tumor (pT): pT3a Margins of resection: Negative Vascular invasion: Positive Regional lymph nodes (pN): pNx Distant metastasis (pM): pMx Specimen A. Left liver Clinical Information Liver carcinoma Gross Description A.  Received fresh for tissue procurement labeled "left liver" is a 425 parenchyma with a 16.5 x 2.4 x 1.2 cm fatty pedicle along one aspect (in keeping with ligament of  The capsular surface is deformed by a bosselated firm subcapsular mass.. On sectioning, the mass is lobulated pale tan-yellow to tan-pink, measuring 8.7 x 7.4 x 6.0 cm. portion of the tumor and a portion of normal parenchyma are submitted A for tissue procurement as requested. The tumor extends to within less than 0.1 cm of the inked capsular surface and is 3.2 cm from the cauterized margin of resection. A pale firm focus measuring 3 cm in greatest dimension is noted at the margin (in keeping with cautery artifact see block 5). red-brown without additional mass lesion or abnormality. Summary: 1 through 4 - tumor to inked capsular surface, 5 - closest margin of resection including additional pale focus, 6 through 8 tumor to normal parenchyma, 9  - random parenchyma, 10 - parenchyma to. attached ligament 1<d-0 3 Carcinomg hpaF<elulgr NOs 870|3 Sit: liver Ca3.0
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diff --git a/output/text/3f002827-473f-4bc3-a63c-0d1a76a10b34.txt b/output/text/3f002827-473f-4bc3-a63c-0d1a76a10b34.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c0891b53824386ec84b751fa51c45d78f24a2edc
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+1CS -0-3 Carcionu, Wrothehkl 81xOj3 Site : sladdhr, trigope. C67.0 Patient hIstory: Clinical history is not given. J 4/7/n PRE-OP DIAGNOSIS: Bladder cancer. POST-OP DIAGNOSIS: Same. PROCEDURE: Cystoprostatectomy / neobladder construction. ADDENDA: Collectinn nate: Addendum Multiple additional doeper levels were evaluated from the right dlstal ureteral margin (part 4). These deeper sections show fibrovascuiar, neural and adlpose tissue. No lining urothelial Is seen. No evidence of urothelial carcinoma nor urothelia! carcinoma in situ (CIS) are seon.. This completes my current evaluation of this case. The diagnoses rendered earlier remain unchanged. Thank you for. involving us in the care of this patient. FINAL DIAGNOSIS: PART 1: Lymph nodes, right pelViC, eXcision -  MEtastaTic CarciNOmA IN One Of elEven Lymph nODes (1/11). A B.  nO extracapsuLAr extension pResent. PART 2: Lymph noDes, Left pelvic, excisiOn - A.  METASTATIC CARCINOMA IN THREE OF TWELVE LYMPH nODES (3/12). B. EXTRACAPSULAR EXTeNSION PRESEnt. PART 3: BLADDer, prOstate And bILAteral Seminal VeSIcles, RaDiCal CystOprOstatectomy - A.  INVASIVE UROTHELJAL CARCINOMA (3.3 CM), HIGH GRADE (WHO/ISUP), GRADE 3 OF 4 (ASH). B.  THE CARCINOMA EXTENDS INTO THE PERIVESICAL ADIPOSE TISSUE. C. THE INKED PERIVESiCAL SOFT TISSUE SURGiCAL mARGIN iS INVOLVED VERY FOCALLy IN THE LEFT TRIGONEJ Left LATeral wall REgIon Of tHe BLADDer (SLiDe 3C).E D. METASTATIC ADENOCARCINOMA iN ONE OF ONE LEFt PERIVESiCAL LyMPH nODES (1/1). E.  NO CARCINOMA IN SITU (CIS) IDENTIFIED. F ANGIOLYmPHATIC iNVASION IDENTIFIED. G. Tnm PaTHOLOgIC sTAGIng = T3bN2 mX. H. TNm histopathOlogic grADe = g3. 8Enign PROSTaTIC TisSUe wITH FOCAl CHrOnIc infLAmmAtiOn. PART 4: Ureter, Right DIstal, BiopSy -- UUID:E686842F-3A8C-4181-836E-79D4443DC0CD  BENIGN FIBROADIPOSE TISSUE. TCGA-BT-A20Q-01A-PR A. Redacted B. nO tumOr present. MICROSCOPIC:  SyNOPTIC DATA - PRIMARY URINARY BLADDER TUMORSE SPECIMEN TYPE: Radical cystoprostatectomy TUMOR SITE: Trigone, Left lateral wall TUMOR SIZE: Greatest dimension: 3.3 cm HISTOLOGIC tYpE:  Urothelial (transitional cell) carcinoma ASSOCIATED EPITHELiAL LESIONS: None identified HISTOLOGIC GRADE: Urothelial carcinoma - High-grade TUMOR CONFIGURATION: Solid/nodule, Ulcerated PAThOLOGIC STAGING (pTNM): pT3b pN2 Number of nodes examined: 23 Number of nodes involved: 4 pMX  MARGINS:  Margin(s) involved by invasive carcinoma Margin(s): left utereal VENOUS/LymPHATIC (LARGE/SmALL) VESSEL iNVASiON (V/L):  Present DIRECT EXTENSION OF INVASIVE TUMOR:  Perivesical fat ADDITIONAL PATHOLOGIC FINDINGS:  Inflammation/regenerative changes
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diff --git a/output/text/3f18a4de-8696-4e75-9921-d4e286cfd5d3.txt b/output/text/3f18a4de-8696-4e75-9921-d4e286cfd5d3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4e2e3435562ff6eb492117129014c819c305836a
--- /dev/null
+++ b/output/text/3f18a4de-8696-4e75-9921-d4e286cfd5d3.txt
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+
+--- Page 1 ---
+UUID: E8A860C3-7252-43DC-BF10-6E8614FC9AD2 Redacted TCGA-NP-A5GY-01A-PR  Patient: Referring Physician: Gender: F Ref#: Hosp#: Patient Location Date of Service: Inpatient FinAl SuRgICAL PATHOLOgy rEpOrt Diagnosis: Renal maSs, LEft LOwer POLe, partial nephrectOmy: - CHrOmOphOBE RENAl CELL CARCINOMA, NUCLEAR GRaDE 2 - EosinophILic type, 2.2 cm. - RENAL PARENCHYMAL MARGIN FOCALLY POSITIVE PATHOLOGIC TUMOR STAGING SUMMARY: - Histologic type and grade: Chromophobe renal cell carcinoma, eosinophilic type, nuclear grade 2 out of 4. - Primary tumor: pT1a, 2.2 cm.. - Regional Iymph nodes: NA. - Distant metastasis: NA - Pathologic stage: I. - Margin status: R1, focally positive at renal parenchymal (resection) margin. - Lymphovascular and perineural invasion: Not identified. COMMENT: Intradepartmental consultation with is obtained. The carcinoma focally involves inked-cauterized renal parenchymal margin. The diagnosis is called to Icdo~3 Ccrcinomo,neual Csll Ch^omophobe type 8317/3 Site: O Kidney NsS Cb4.9 M 12/20/12 Case #: Page 1 This report continues... (FINAL)
+
+--- Page 2 ---
+Case # FINAL SURGICAL PATHOLOGY REPORT Kidney Tumor Staging Information Data derived from current specimen. Staging in accordance with or modified from AuCc Cancer Staging Handbook, 7th Ed, and CAP protocol. Procedure: Partial nephrectomy Specimen type: Left lower pole partial nephrectomy Specimen laterality: Left. Tumor Features: Tumor size: 2 2 cm. Tumor focality: Unitocal. Histologic type: Chromophobe renal cell carcinoma, eosinophilic-type. Histologic grade (Fuhrman nuclear grade): Nuclear grade 2 out of 4 Sarcomatoid features: Absent. Macroscopic extent of tumor: Tumor limited to kidney. Microscopic tumor extension Tumor limited to kidney. Lymph Nodes: N/A (none submitted). Margins:  Margin involved by invasive carcinoma (rena). parenchymai margin). Pathologic tumor staging descriptors:  Primary tumor (pT): pT1a.  Regional Lymph nodes (pN): NIA, Distant metastasis (pM): NIA. Margin status (R) R1, renal parenchymal margin tocally involved. Pathologic stage: Pathologic findings in non-neoplastic kidney:.  Patchy glomerulosclerosis and chronic inflammation Additional pathologic findings: N/A Comment: N/A. Case # Page 2 report continues... (FINAL)
+
+--- Page 3 ---
+I Patient: Case # FINAL SURGICAL PATHOLOGy REPORT Source of Specimen: Left Renal Mass Clinical History/Operative Dx: Left renal mass Gross Description. The specimen is designated as left renal mass. Initially received in the fresh state for possible tumor bank studies is a 5 gram portion of renal tissue, 2.7 x 2.3 x 1.8 cm. The renal surtace is raised, glistening, tense..  The surgical margin is now marked blue and the renal capsule is marked green. Sectioning demonstrates a well-circumscribed, glistening, somewhat fleshy. pink and tan lesion, 2 2 x 1.8 x 1.6 cm. Centrally, the lesion demonstrates a softened hemorrhagic appearance over an area 1.8 x 0.8 x 0.7 cm. Representative  portions of grossly viable tumor is submitted for tumor bank studies. The remainder of the specimen is entirely submitted for routine histology in A1-A4 Microscopic Description: The sections show an a thinly encapsulated neoplasm with central zone of hemorrhage. The neoplastic cells have abundant granular-eosinophilic cytoplasm, distinct perinuclear halos, occasional binucleation, foci with wrinkled nuclear membranes, and scant nuclear atypia (but with scattered small nucleoli). No Iymphovascular or perineural invasion is seen. While most of the margin is negative (microscopically free with a thin fibrous capsule)., there is focal involvement of the inked-cauterized margin. A panel of  immunostains shows the tumor to have strong expression of CK7 and CKa/18, and rare cells with. expression ot CD10 (but to be negative for: CD15/CD117/Vimentin), which together with the morphology is. consistent with a chromophobe renal cell carcinoma Case # Page 3 REPRINT:Orig.printing on Chromw phobe Criteria 1218
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diff --git a/output/text/3f3c02d4-33db-4dad-b433-f096be2d6258.txt b/output/text/3f3c02d4-33db-4dad-b433-f096be2d6258.txt
new file mode 100644
index 0000000000000000000000000000000000000000..87d089746e23bcc10506db9ddd189e197f232f74
--- /dev/null
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+
+--- Page 1 ---
+rinted: Department of Pathology Page 1 of 4 REPORT Tel: UUID:9FFFF089-4156-4221-BCAC-20EEB748944C TCGA-VD-A8KF-01A-pR Redacted Clinical Consultant & Location  Sex Unit No This Copy For: tcd-o.3 SPECIMEN Right eye. cel mizeel' 8770/3 Leolen c CLINICAL DETAILS Site: Dneloppirsy Inferior ?----? detachment (variable thickness. ey+ adnefoICi9.8 MACROSCOPIC DESCRIPTION yO 1117/14 An intact right eye. Dimensions: Axial 26mm; Horizontal 25mm; Vertical 26mm. Cornea: Horizontal 12mm; Vertical: 12mm. Optic nerve: Length 2mm; Diameter Smm. Pupil: Slightly eccentric towards inferior edge. On trans-illumination, a shadow is seen in the inferior pole measuring 19 x 20mm. Plane of section: Vertical. Intraocular description: On opening the eye, an amelanotic bilobated ciliochoroidal mass is present measuring 20mm at its larger base and 6.7mm in height. Tumour extends posteriorly to within 6mm of the optic disc. Tumour size LBD 20mm Height 6.7mm MICROSCOPY Sections show a non-pigmented ciliochoroidal melanoma associated with exudative retinal detachment. The tumour consists of a mixed cell population in which the epithelioid cell component amounts up to 80%. Tumour cells express Melan-A and Hsp 27 (score 2). The number of mitosis is high, approximately 16/40 high power fields. The microvasculature of the melanoma is Reported: Pathologist: Electronically Verified:
+
+--- Page 2 ---
+Department of Pathology Page 2 of 4 HISTOPATHOLOGY REPORT Tel:  Surname Lab No Clinical Consultant & Locatlon DOB/Age Forename(s)  Sox Unit No Request Date This Copy For: prominent, and closed loops are present in the planes of. section. The lymphocytic infiltrate within the tumour is minimal. Tumour necrosis is not seen. There is focal tumour extension into the sclera. Optic nerve and vortex veins examined show no evidence of tumour involvement. There is no convincing evidence of ring pattern of spread. Tumour cells are not seen at the resection margins. Elsewhere, the cornea shows no significant abnormality. The anterior chamber angles are open and the anterior chamber is deep. The iris appears uninvolved. The lens shows subcapsular degenerative changes. Retina overlying the tumour is slightly atrophic and Bruch's membrane appears intact in the sections examined. DIAGNOSIS Right enucleation -  Ciliochoroidal melanoma of mixed cell type. COMMENT SPECIMEN 2= Eye TUMOUR PRESENT Yes TUMOUR TYPE 1= Melanoma CELL TYPE 3= Mixed CT LOOPS 2= Closed loops NECROSIS No PIGMENTATION No LYMPHOCYTIC INFILTRATION No /40 HPF MITOTIC FREQUENCY 16 DIFFUSE MELANOMA  No SPREAD 2= Intra-scleral. CLEARANCE 2= Adequate HSP-27 POSITIVITY 2= 21-70% Reported: Pathologist: Electronically Verified:
+
+--- Page 3 ---
+Department of Pathology Page 3 of 4 HISTOPATHOLOGY REPORT Tel:  Surname Lab No Cllnlcal Consultant & Location Forename(s)  DOB/Age Sex UnIt No Request Date This Copy For: LARGE DIAMETER 20 mm THICKNESS 6.7 mm COMMENT In the meantime, molecular genetic analysis of tumour DNA extracted from fresh uveal melanoma tissue was performed. using the technique termed multiplex ligation-dependent probe amplification (MLpA). These investigations were performed in the The kit p027 from  which examines for gains or. losses in 31 loci on chromosomes 1, 3, 6 and 8, was used.. The DNA concentration was measured using  and the quality assessed using multiplex-pcR prior to the MLPA reaction. The DNA concentration was high and of good quality on assessment. The MLpA reaction was run at least twice on differing occasions, resulting in similar results. The results of the sequence analysis of the MLpA products is. printed on a separate report. In summary, sequence analysis demonstrated: normal chromosome 1,. monosomy 3, normal chromosome 6p and gains of chromosome 8q.. These molecular data require correlation with the clinical and morphological data for metastatic risk assessment. SUPPLEMENTARY REPORT On request of the treating clinicians, BRAr testing of the primary tumour was performed. The sample was analysed for. BRAF vsong aene mutation using the BRAF RGQ PCR kit on a PCR cycler. The DNA was of sufficient quality: there was no v600E Reported: Pathologist:  Electronically Verified: 3 rimaly Tumor Site Discrepancy ua/Syn.w nse isc.rcle): QUALIELE iewed
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diff --git a/output/text/3f3d3f87-ffe0-4c21-9891-89e50fd8a7ff.txt b/output/text/3f3d3f87-ffe0-4c21-9891-89e50fd8a7ff.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2138da678fc2389881094016fdcf0db2c501b44e
--- /dev/null
+++ b/output/text/3f3d3f87-ffe0-4c21-9891-89e50fd8a7ff.txt
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+
+--- Page 1 ---
+JCs-0 -3 Carcinoma, mfilnatng ductaP Nos 8500/3 Site: brsst Nos c50.9 1/78/1 Pathology Form Specimen Information Date: Collected by Time: Preserved by:  Date: me: U MSPECIMENTYPE#f samples provided). Paraffin Block CBlood/Serum/Plasma Slide Frozen. Normal Diseased Normal Diseased  Normal Diseased Normal Diseased x Time to Formalin Time to LN2 Time to LN2 min 10 min min o MEAEWPATHOLOGICALDESCRIPTIONTSS T Primary Tumor Organ Size Extension of Tumor Distance to NAT Peeert NO 2 3 x cm cm Lymph Nodes # Examined # Metastasized Location Axilla s 0 Distant Metastasis Size Organ Detailed Location no Pathological Staging No Stage: 1LA pT q Notes: UUID:150DD5CB-1CA0-4110-95A7-6476B5B6FC24 TCGA-C8-A12L-01A-PR Redacted
+
+--- Page 2 ---
+D#: Microscopic Description ***wwwwww*.HistologiPatternw Structural Pattern Cell Distribution + + Streaming Diffuse  Storiforn Mosaic Fibrosis Necrosis  Palisading Lymphocytic Infiltration  Cystic Degeneration Vascular Invasion  Bleeding Clusterized  Myxoid Change  Alveolar Formation  Psammoma/Calcification Indian File Cellular Differentiation  Lymphomatous + Sarcomatous + Adenomatous +  Squamous +  Large Cell Round Cell Glandular cell + Small Cell  Squamoid Cell Fibroblast  Cell Stratification  RS Cell/RS Like  Spindle Cell Osteoblast  Secretion  Inflam. Cell Keratin  Lipoblast Intracyt. Vacuole Plasma Cell  Desmosome Myoblast  Gland formation Poor Pear! Well  Moderate Cellular Differentiation: 1I III wwsuclear Appearance.sw 1 0 + Nuclear Atypia:  Aniso Nucleosis Hyperchromatism  Nucleolar Prominent + Multinucleated Giant Cell t Mitotic Activity Nuclear Grade: Date sHCDatan Value Result  Marker  Negative  Positive ER  Negative  Positive PR  Positive  Negative  Her-2/neu Negative Positive  B-Cell Marker  Negative  Positive T-Cell Marker Negative   Positive Other:  Negative  Positive Other: Finai Pathology Report Inraire duchl Cariuua Grade: 1 Histological Diagnosis: Comments: Date Pathologist Principal Investigator
+
+--- Page 3 ---
+COnsOLIDateD DIAgNOsTIC paThOLOgy fORm* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION Diffuse STRUCTURAL PATTERN  Streaming  Mosaic *  Storiform Necrosis Lymphocytic Infiltration Fibrosis  Palisading Vascular Invasion Clusterized A Cystic Degeneration Alveolar Formation 9 Bleeding Jndian File K  Myxoid Change Psammoma/Calcification 2. Cellular features: Squarmous + Adenomatous * Squamoid Cel! Sarcomatous + Lymphomatous Glandular cell 7X Round Cell Spindle Cell Cell Stratification Large Cell Fibroblast Keratin Small Cell  Secretion Osteoblast Desmosome  RS CeIVRS Like Intracyt. Vacuole Lipoblast Inflam. Cell Pearl Gland formation Myoblast  Plasma Cell Otherwise Specified: P,707 Dr0o7 Aerasr 2.Cellular Differentiation: Well Moderately  Poor Nuclear Atypia: Nuckear Appearance III Aniso Nuclcosis Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity Nuckear Grade Histological Diagnosis: Togltehisy lsttad Caali'nsrq, Lo Comments: Date PATHOLOGIST STAFF FOR RESEARCH USE ONLY). (INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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diff --git a/output/text/3f8c2629-4b08-48b7-b7d7-641eef456949.txt b/output/text/3f8c2629-4b08-48b7-b7d7-641eef456949.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d4b6a6aefc9b19448b17ea3cc3d701b931fd59eb
--- /dev/null
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+
+--- Page 1 ---
+Histopathology Report Biopsy No Corrected Histopathology Report Final Updated ADDENDUM ADDENDUM TO HISTOPATHOLOGY REPORT The following immunoprofile is obtained in this. malignant lymphoma: CD3, 5, 10: Negative Cyclin D1: Negative CD 21, 23: Negative. There is a.  suggestion of an adjacent follicular area with CD 21, but no staining with cD 10. BCL2, 6: Positive for both. Though BCL 6. positive,  cells are cD 10 negative CD 20: Positive CD 79a: Positive Ki 67/MIB1: Activity from 80 to 90%. In summary, this tumor is classified as a Diffuse large "B" cell lymphoma (CD20 and CD79A+, CD 5, 10 and cyclin D1-).  This lymphoma has a diffuse pattern, with tumor cells of medium to large size and clearly marking with CD 20 and CD 79a and. negative for Cyclin Dl. Amended Diagnosis: Diffuse, large "B" cell lymphoma (DLbcL). NoTe : Please see below for original report.. DIAGNOSIS Supraclavicular lymph node, biopsy:. Malignant lymphoma, immunoprofile and classification will follow with addendum.. GROSS DESCRIPTION Received in formalin is a specimen labelled with patient's data, and designated "left supraclavicular lymph node". It consists of two irregular pieces of fleshy tissue measuring 1.5 x 1 x 0.3cm and 1.1 x 1 x 0.5cm. (Al; no reserve) MICROSCOPIC DESCRIPTION This is an adequate excisional biopsy.  The features are in keeping with a malignant lymphoma. Immunoprofile ordered and addendum report" will follow with. typing of malignant lymphoma. There are areas of geographic necrosis, suggestive of changes post fine needle biopsy.. Pathologist : Printed from:
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diff --git a/output/text/3f8d43fe-271f-457c-bb8b-e05a9f36dd9a.txt b/output/text/3f8d43fe-271f-457c-bb8b-e05a9f36dd9a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3c79c8fb38551efdf79b88b423f3f9fd57cb2646
--- /dev/null
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+
+--- Page 1 ---
+Page I of 6 UUID:F6165489-A305-40B9-97FE-A2289EE1375D TCGA-R4-A5RI-01A-PR Redacted Gender F Date Of Birth Encounter Number COPY ONLY DO NOT FILE SURGICAL PATHOLOGY Time Collected Time Reported Ordering Provider Status Final Results 1cs~0-3 Cmcinoms Wrsthelial No5 81sof3 Fina1 Source of Specimen. A.  LEFT PELVIC LYMPH NODES~ FS- SitL: 31sdr, gosterinr urll Cl7.4 3. LEFT PELVIC LYMPH NODES-NFS- C. RIGHT PELVIC LYMPH NODES-FS- D. RIGHT PELVIC LYMPH NODES-NES- 0/17/13 E. APPENDIX- F. LEFT URETER MARGIN-FS- G. RIGHT URETER MARGIN-FS- H. BLADDER, UTERUS, BILATERAL FALLOPIAN TUBES SEE WORKSHEET- FINAL DIAGNOSTS: A. LEFT PELVIC LYMPH NODES- FS- THREE FATTY LYMPH NODES, NO MALIGNANCY SEEN. B. LEFT PELVIC LYMPH NODES-NFS- SEE PART "A". C. RIGHT PELVIC LYMPH NODES-FS- TWO FATTY LYMPH NODES, NO MALIGNANCY SEEN. D. RIGHT PELVIC LYMPH NODES-NES- SEE PART "C". F. APPENDIX- VERMIFORM APPENDIX WITH NC DIAGNOSTIC ABNORMALITY SEEN. F. LEET JRETER MARGN-F3-  NO CARCINOMA SEEN. G. RICHT URETFR MARGIN-ES- NO CARCINOMA SEEN. H1. BLADLER, UTERUS, BILATERAL FALLOPIAN TJBES SEE WORKSHIEET- INVASIVE CARCINOMA, HIGH GRADE.  Prepare
+
+--- Page 2 ---
+Page 2 of 6 TUMOR SITE: POSTERIOR, URINARY BLADDER. HISTOLOGIC TYPE: UROTHEI.IAL. SQUAMOUS DIFFERENTIATION: NOT PRESENT. GLANDULAR DIFFERENTIATION: IS PRESENT, EXTENSIVE. TUMOR SIZE: 3.0 CM. HISTOLOGIC GRADE: 3/3. TUMOR INVADES PERIVESICAL SOFT TISSUE, MICROSCOPICALLY. SPECIMEN TYPE: ANTERIOR EXENTERATION: RADICAL CYSTECTOMY, TOTAL HYSTERECTOMY AND BILATERAL SALPINGOOPHORECTOMY, ANTERIOR VAGINECTOMY. TNM STAGE: pT3a, pN0, pMX. LYMPH NODE(S) INCLUDED IN ALL PARTS: NUMBER INVOLVED: 0 NUMBER EXAMINED: 5 LYMPHATIC (SMALL VESSEL) INVASION: IS PRESENT. PERINEURAL INVASION: PRESENT, EXTENSIVE. ASSOCIATED EPITHELIAL LESIONS: EXTENSIVE SURFACE ULCERATION. MODERATE UROTHELIAL DYSPLASIA FOCALLY SEEN. NO TUMOR SEEN AT URETERAL AND URETHRAL MARGINS. PERIVESICAL SOFT TISSUE MARGIN: NEGATIVE FOR TUMOR. VAGINA, UTERUS AND CERVIX: NEGATIVE FOR MALIGNANCY. OTHER BENIGN FINDINGS: ATROPHiC EndOMETRiUM. INTRAMURAL LEIOMYOMATA. ATROPHIC OVARIES WITH FOCAL ENDOSALPINGIOSIS. PARATUBAL CYSTS. Signature Prepar
+
+--- Page 3 ---
+Page 3 of 6 Signed Others I'rozen Section A. RIGHT URETER MARGIN: NO CARCINOMA. I.FFT URETER MARGIN: NO CARCINOMA. RIGHT AND LEFT FELVIC LYMPH NODES: FATTY LYMPH NODES ON BOTH SIDES, REPRESENTATIVE SECTIONS TAKEN FOR FS. RIGHT PELVIC LYMPH NODES: 2 FATTY LYMPH NODES. NO TUMOR SEEN (0/2). LEFT PELVIC LYMPH NODES: 3 FATTY LYMPH NODES. NO TUMOR SEEN (0/3). Frozen section performed by Case Clinical Information BLADDER CANCER Gross Description A. Received in formalin labeled with the paticnt's name and "left pelvic lymph nodes Fs" are three fatty, yellow-tan tissue fragments measuring up to 2 x l.2 x 0.2 cm thick. The entire specimen is submitted in Al.. B. Received in formalin labeled with the patient's name and "left pelvic lymph nodes NFs" are multiple fragments of finely divided fat, measuring 3 x 3 x 3 cm in compact aggregate. Residual induration is submitted in B1-B3. C. Received in formalin labeled with the patient's name and "right pelvic lymph nodes Fs" are two elongated, fatty, pink-tan lissues measuring 2 x l.1 x 0.2 cm thick. The entire specimen is submitted in Cl. D. Received in formalin labeled with the patient's name and "right pelvic lymph nodes Nrs" are multiple fragments of finely divided fat, measuring 3 x 3 x 3 cm in compact aggregate. Residual induration is sabmitted in Dl-D3. F. Received in formalin labeled with the patient's name and "appendix" is a grossly unremarkable vermiform appendix with attached periappendiccal fat measuring 7 x 0.4 cm thick, with the surgical margin revealing a staple closure. The appendiceal lurren is pinpoint. A shave of the resection margin adjacent to Prepared :
+
+--- Page 4 ---
+Page 4 of 6 the staple closure and entire appendiceal tip is submitted in El. F. Received in formalin labeled with the patient's nane and "left ureter Fs" is yellow tan, sott tissue measuring l x 1 x 5.2 cm. Totally submitted in F1. G. Received in formalin labelcd with the patient's name and. "right ureter Fs" is yellow-tan, soft tissue measuring 9 x 6 x 1 mm thick. The specimen is submitted totally in G1. H. Received in formalin labeled with the patient's name and "ut.erus, bilateral tubes and ovaries, bladder, anterior vaginal wall" is a specimen so designated, measuring overall 13 cm superior to inferior, 10 cm right to left, 8 cm antorior to posterior.  The uterus and cervix measure 7 cm superior to inferior, 4.5 cm right to left, 2.2 cm anterior to posterior.. Unremarkable right and left fallopian tubes, measuring 6.5 x 0.6 and 6 x 0.5 cm with unremarkable, atrophic appearing right and left ovaries measuring 2 x 1.5 x 0.6 and 2 x 1.5 x 0.6 cm in. greatest dimensions. The included portion of anterior vaginal wall is continuous with the perineal and distal urethral mucosa, it measures up to 5 cm in width superiorly and appears unremarkable.  The cervix is 3 cm in diameter with a 1.2 cm linear os..  The specimen previously has boen inked blue on the left, black on the right, and the bladder cavity is exposed. The bladder wall appears indurated with a diminished bladder. cavity measuring 2.5 cm right to left, superior to inferior, 2 cm anterior to posterior.  The posterior superior aspect of the bladder is replaced by an area of ulceration and induration, measuring 3 x 3 cm. Section code: H1-distal urethra; H2-shaved entire left vaginal resection margin; H3-shaved entire right vaginal resection margin; H4-left cross sections mid urethra; H5-right mid urethral cross sections; H6-half left ovary; H7-left fallopian tube; H8-half of right ovary; H9=right. fallopian tube; Hl0-posterior cervix; Hll=anterior cervix; H12-Hl3-anterior posterior uterine wall, including thin endometrium and two fibroid-like nodules with uterine cavity measuring 1.2 cm in width, 2 cm in length; H14-H18-extensive sampling of bladder tumor,  which measures up to 2 cm thick,. deeply penetrating posterior bladder fat. H19-h20-tumor to inked left posterior soft tissue margin. The included stubs of ureter are deeply retracted and are not sampled at this time due to their presence in parts Fl and G1 Physicians Procedure A. AA ROUTINF HE X1 3LOCK HEE X1 B. AA ROUTINE HSE XI BLOCK.1  Prepared
+
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+Page 5 of 6 H&E X1 B. AA ROUTINE HSE X1 BLOCK.2 H&E X1 B. AA ROUTINE H&E X1 BLOCK.3 H&E X1 C. MA ROUTTNE H&E X1 BLOCK H&F X1 D. AA ROUTINE H&E X1 BLOCK.1 H&E X1 D. AA ROUTINE H&E X1 BLOCK.2 H&F X1 D. AA ROUTINE H&E X1 BLOCK.3 H&E X1 E. AA ROUTINE H&E X1 BLOCK H&E X1 F. AA ROUTINE H&E X1 BLOCK H&E X1 G. AA ROUTINE H&E Xi BLOCK H&E X1 H. AA ROUTINE H&E X1 BLOCK.1 H&E X1 H. AA ROUTINE H&E X1 BLOCK.2 H&E X1 A RECUTS H. AA ROUTINE H&E X1 BLOCK.3 H&E X1 A RECUTS H. AA ROUTINE H&E X1 BLOCK.4 H&E X1 H. AA ROUTINE H&E X1 BLOCK.5 H&E X1 H. AA ROUTINE H&E X1 BLOCK.6 I&E X1 H. AA ROUTINE H&E X1 BLOCK.7 H&E X1 H. AA ROUTINE H&E X1 BLOCK.8 H&E X1 H. AA ROUTINE H&E X BLOCK.9 H&E X1 H. AA ROUTINE H&E X1 BLOCK.10 H&E X1 A RECUTS H. AA ROUTINE H&E X1 BLOCK.11 H&E X1 11. AA ROUTINE H&E X1 BLOCK.12 H&E X1 H. AA ROUTINE H&E X1 BLOCK.13 H&E X1 H. AA ROUTINE H:&E X1 BLOCK.14 H&E X1 H. AA ROUTINE H&E X1 3LCCK.15 Prepared 1
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+Page 6 of 6 H&L X1 H. AA ROUTINE H&E X1 BLOCK.16 H&E X1 11. AA ROUTINE H&E X1 BLOCK.17 HEE X1 H. AA ROUTINE HI&E X1 BLOCK.18 H&E X1 H. AA POUTINE H&E X1 BLOCK.19 H&E X1 H. AA ROUTINE H&E X1 BLOCK.20 H&E X1 Prepared
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diff --git a/output/text/3fc609de-8844-4582-a971-bbc1ea1ce99a.txt b/output/text/3fc609de-8844-4582-a971-bbc1ea1ce99a.txt
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index 0000000000000000000000000000000000000000..219c3f354c52b5aba4a946ddefc489da19090ab6
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+Cels J8qwbl 3 SURGICAL PATHOLOGY Sute: RYwolney NoS Cw49 Accession #: Collected: Received: 11|29|13 PATHOLOGIC DIAGNOSIS A: KIDNEY, RIGHT MID LATERAL, TUMOR, PARTIAL NEPHRECTOMY: - PAPILLARY RENAL CELL CARCINOMA, TYPE II (4.5 CM) - FUHRMAN NUCLEAR GRADE 3 - RENAL PARENCHYMAL MARGIN INVOLVED BY INVASIVE CARCINOMA - SEE SYNOPTIC REPORT, BELOW B: KIDNEY, RIGHT LOWER, TUMOR, RESECTION: - PAPILLARY RENAL CELL CARCINOMA, TYPE II (1.4 CM) - FUHRMAN NUCLEAR GRADE 2 - RENAL PARENCHYMAL MARGIN INVOLVED BY INVASIVE CARCINOMA - RENAL CAPSULAR MARGIN APPEARS UNINVOLVED C: KIDNEY, RIGHT MID ANTERIOR, TUMOR, BIOPSY: - PAPILLARY RENAL CELL CARCINOMA, TYPE II - FUHRMAN NUCLEAR GRADE 2 - TUMOR SIZE: APPROXIMATELY 0.8 CM (SEE COMMENT) D: KIDNEY, RIGHT SUPERIOR LATERAL, TUMOR, BIOPSY: - PAPILLARY RENAL CELL CARCINOMA, TYPE I - FUHRMAN NUCLEAR GRADE 1 - TUMOR SIZE: APPROXIMATELY 0.1 CM (SEE COMMENT) UUID: E57FFF7C-7AE1-43F0-9C72-E0C287CF2B3A Tcga-mh-A854-01A-pr Redacted E: KIDNEY, RIGHT UPPER MEDIAL, LESION, BIOPSY: - PAPILLARY RENAL CELL CARCINOMA, TYPE II - FUHRMAN NUCLEAR GRADE 2 - TUMOR SIZE: APPROXIMATELY 0.5 CM (SEE COMMENT) SYNOPTIC REPORT: - PAPILLARY RENAL CELL CARCINOMA, TYPE II, FUHRMAN NUCLEAR GRADE 3 - TUMOR FOCALITY: MULTIFOCAL - TUMOR SIZE: 4.5 X 4 X 2.5 CM (LARGEST TUMOR, PART A) - MACROSCOPIC EXTENT OF TUMOR: TUMOR LIMITED TO KIDNEY - MICROSCOPIC TUMOR EXTENSION: TUMOR LIMITED TO KIDNEY - SARCOMATOID FEATURES: NOT IDENTIFIED - TUMOR NECROSIS: NOT IDENTIFIED - LYMPH-VASCULAR INVASION: NOT IDENTIFIED - MARGINS: - RENAL PARENCHYMAL MARGIN INVOLVED BY INVASIVE CARCINOMA
+
+--- Page 2 ---
+- RENAL CAPSULAR MARGIN: APPEARS UNINVOLVED - PERINEPHRIC FAT MARGIN: NOT APPLICABLE - PATHOLOGIC FINDINGS IN NONNEOPLASTIC KIDNEY: - APPROXIMATELY 5% GLOMERULOSCLEROSIS - FOCAL TUBULAR ATROPHY WITH ENDOCRINIZATION - MODERATE ARTERIOLOSCLEROSIS - OTHER TUMORS: - MULTIFOCAL PAPILLARY RENAL CELL CARCINOMA - SEE PARTS B-E, ABOVE - PATHOLOGIC STAGING: - TNM DESCRIPTORS: m (MULTIPLE PRIMARY TUMORS) - PRIMARY TUMOR: pT(m)1b (TUMOR 4-7 CM IN GREATEST DIMENSION, LIMITED TO THE KIDNEY) - REGIONAL LYMPH NODES: pNX (NO NODES SUBMITTED OR FOUND) - DISTANT METASTASIS: NOT APPLICABLE Staff Pathologist COMMENT: The tissue submitted in parts C-E was fragmented; adequate assessment of surgical margin and accurate tumor size is not possible Gross Description Specimen Material: A. Renal, R mid lateral tumor:. B. Renal, R lower pole tumor: C. Renal, R mid anterior tumor: D. Renal, R superior lateral tumor E. Renal, R upper medial lesion: Part A: The specimen is received in formalin, labeled "RIGHT MID LATERAL RENAL TUMOR", and consists of a 28 gram well-circumscribed, circular mass (4.5 x 4 x 2.5 cm). One side of the renal mass has a rim of normal-appearing, tan-gray renal parenchyma; the other side is an encapsulated firm mass. The specimen is serially sectioned, and the cut surface shows a friable, hemorrhagic, yellow mass that does not appear to extend through the renal capsule. The tumor abuts the inked resection. margin. A portion of this tumor is submitted for further studies (tissue banking). Ink Code:
+
+--- Page 3 ---
+Resection margin of kidney orange Cassette Code: A1-8: Inked renal resection margin with adjacent tumor (resection margin. entirely submitted) A9: uninvolved renal parenchyma Part B: The specimen is received in formalin, labeled "RIGHT LOwER LOBE RENAL TUMOR", and consists of a single tan-gray nodule (1.7 x 1.5 x 0.7 cm). The cut surface shows a hemorrhagic yellow nodule. The specimen is. serially sectioned and entirely submitted in B1-2. Part C: The specimen is received in formalin, labeled "RIGHT ANTERIOR MID LESION RENAL TUMOR", and consists of two tan-gray nodules (1.2 x 0.6 x 0.4 cm in aggregate). The specimen is entirely submitted in cassette C1. Part D: The specimen is received in formalin, labeled "RIGHT SUPERIOR LATERAL RENAL TUMOR", and consists of two tan-gray fragments of tissue (1.8) x 1.4 x 0.4 cm in aggregate). The specimen is submitted entirely in D1. Part E: The specimen is received in formalin, labeled "RIGHT UPPER MEDIAL RENAL LESION", and consists of multiple fragments of tan-gray tissue (0.9 x 0.7 x 0.3 cm in aggregate). The specimen is entirely submitted in cassette E1. Pathology Resident Microscopic Description A-E: Performed. Intradepartmental consultation: has examined this case. and agrees with the findings and interpretation. The staff pathologist listed below has reviewed this case. **Electronically Signed Out** Staff Pathologist Z3
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diff --git a/output/text/404160b3-bbc9-4ec2-a061-50f4e7b5c2f5.txt b/output/text/404160b3-bbc9-4ec2-a061-50f4e7b5c2f5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..30d933ea20c42b42c001f53779ad127f3e115afc
--- /dev/null
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+
+--- Page 1 ---
+UUID:60D48255-2F73-4F45-83D5-6888CC422D1C TCGA-BT-A20X-01A-PR Redacted PATIENT HISTORY: CHIEF COMPLAINT/ PRE-OP/ POST-OP DIAGNOSIS: Bladdor cancer. ProceDure: Total cystectomy. SPECiFiC CLINICAL QUeSTION: Not answered. OutsiDe TisSue DiagnOSiS: Not answered. 1cs-0-3 PRIOR MALIGNANCY: Not answered. CHEMORADIATION THERAPY: Not answered. Carciioma, hro+helicl 812o/3 ORGAN TRANSPLANT: Not an$wered. IMMUNOSUPPRESSION: Not answered. Sitss 51soldhv, cone Cl7.1 OTHER DISEASES: Not answered. 4/7] FINAL DIAGNOSIS: PART 1: Ureter, Left distal margin, Biopsy -- Collection Dato: Segment Of Ureter LiNed sy senIgn urotheLial mucOSA. B.  NO UrOTHeLIAL. CARcinOMA in SITU (CiS) NoR InvaSIVe UrOTHeLiAl CARcinOmA SEEN. Part 2: UreteR, right Distal margin, Biopsy -- SEgment Of UreTer Lined gy Benign UrOtheLal mucO3A. A. B.  nO urotheLial Carcinoma in Situ (Cis) nor invasive urotheLial Carcinoma seen. PART 3: Lymph noDes, presacral, excision - A. fibrofatty tissue only. B. NO LYMPH NODE IOENTIFIED. C. no tumor Seen. PART 4: Lymph nodes, Left pelvic, excision --  NO EVIDENCE OF CARCINOMA IN ONE (0/1) LYMPH NODE EXAMINED. Part 6: Lymph nodes, right pelvic, excision - mETASTATic UrOTHELiAL CARCINOmA in 2 (2/11) LymPh nODES EXAmINED. Part 6:  BLaDDer, radiCal Cystoprostatectomy - A.  invasive UrotheLiaL (TRansitional CeLL) CArcinoma (6.0 Cm). High GRade (Who/isUp), wITh SQuAmOUS FEATURES. B. THe CArCinoma !nvADes through The DeTrusOr musCLe anD exTenDs intO the PERIvesiCLe FaT. C. Tumor extends into the prostatic stroma. D. CArcinOmA Is SEen PResent wIThin 0.1Cm Of The INKed surgiCaL mArgins (SEcTIOn 6h) In The REGiOn Of the right lateral wall. E. One LyMPH nODE POSITIVE fOr CARCiNOMa (1/1). F.  UrotheLiaL CArcinoma In situ is IdentifieD. G. PERINEURAL INVASION IS IDENTIFIED. H.  MULTIFOCAL ANGIOLYMPHATIC INVASION IS iDENTIFIED. Tnm pathologic staging = t4 n2 mx. CYSTITIS CYSTICA AND SQUAMOUS METAPLASIA ARE SEEN. CASE SYNOPSIS:  SynopTic Data - PrimAry uRinary BLADDer tUmOrS SpEcimen Type: Tumor site:  Radical cystoprostatectomy Right lateral wall, Left lateral wall, Antorior wall, Posterior wall, Dome TUmOR SIZE: Greatest dimansion: 5.0 cm HISTOLOGIC TYPE:  Urothelial (transitional cell) carcinoma with squamous differentiation ASSOCIATED EPITHELIAL LESiONS: NonS identified HISTOLOGIC GRADE: Urothelial carcinoma - High-grade TUmOR CONFIGurATION: Solld/nodule, Ulcerated PATHOLOGIC STAGING (pTNm): pT48 pN2 Number of nodes examined: 12 Number of nodes invoved: 3 MArGINS: pMX Margins uninvoived by invasive carcinoma Distance of tumor from closest margin: 1.0 mm VEnOUs/LymphAtic (LARge/SmALl) veSseL (nVAsiOn (V/L): Margin: RIght LATERAL Direct extension or invasive tumoR:  Present Pertvesical fat Prostatic stroma ADDITIONAL PATHOLOGIC FINDINGS: Cystitis cystica glandularis
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diff --git a/output/text/40425db0-ff6f-4db9-a188-99c4c153ab2f.txt b/output/text/40425db0-ff6f-4db9-a188-99c4c153ab2f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..67f80a7b8cbe2dbb2327700df9cfd4098935796f
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+--- Page 1 ---
+Diagnosis/ diagnoses: Right hemicolectomy preparation with an ulcerated colon carcinoma characterized histologically as a moderately differentiated colorectal adenocarcinoma, located at the. junction between the cecum and the ascending colon, extending to Bauhin's valve and measuring 5 cm in diameter at the widest point. Invasive tumor spread to the adjoining mesocolic fatty tissue and beneath the serosa.. Oral and aboral resection margins, appendix and greater omentum are all tumor-free.. 22 mesenteric and mesocolic lymph nodes are tumor-free and with uncharacteristic reactive changes. Stage of tumor is therefore: pT3 pN0 (0/22); L0 V0; G2
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diff --git a/output/text/4042ee5b-cdd9-4bb3-bb08-793ad5cedc42.txt b/output/text/4042ee5b-cdd9-4bb3-bb08-793ad5cedc42.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e98a6c97c67a8d992f04b5bfe083b55741bfdba7
--- /dev/null
+++ b/output/text/4042ee5b-cdd9-4bb3-bb08-793ad5cedc42.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+ UUID: 2AA8FA9B-A202-48AB-A543-6E0B1B45B1D4 tcD-o-3 TCGA-OU-A5PI-01A-PR Redacted CorFical 8370/3 Site: Adreuol Eland;cortek C74.D AS q1i/3 SPECIMEN(S): A. PORTION OF 1OTH RIB B. LEFT KIDNEY AND ADRENAL GLAND C. PARA AORTIC LYMPH NODE D. RIGHT LOWER LOBE LUNG WEDGE RESECTION E. RIGHT LOWER LOBE NODULE/WEDGE #2 F. RIGHT MIDDLE LOBE NODULE/WEDGE CLINICAL HISTORY:S PRE-OPERATIVE DIAGNOSIS GROSS DESCRIPTION: A. PORTION OF 10TH RIB Received fresh with patient's identification and designated "portion of 1Oth rib" are 2 tan pink bone segments, 3.2 x 1.2 x 0.5 cm and 4 9 x 1.2 x 1 cm, show no grossly visible lesions, representatively submitted in cassette A1, following decalcification.. B. LEFT KIDNEY AND ADRENAL GLAND Received fresh with patient's identification and designated "left kidney and adrenal gland" is a left kidney with peri renal fat and the attached adrenal gland, weighing 1243 g, with overall measurements of 24.0 x 9.5 x8.5 cm (the kidney measures 10.5 x 7.5 x 4.5 cm, the adrenal gland measures 13.5 x 9.5 x 8.5 cm). The specimen is inked blue. The attached segment of ureter measures 3 cm in length, 0.5 cm in diameter, the renal vein measures 1 cm in length, 0.5 cm in diameter and the renal artery measures 1 cm in length by, 0.3 cm in diameter. Upon bivalving the specimen, the kidney shows tan-brown cortex. with a well defined cortico-medullary junction. The pelvis and calyces are covered by smooth, glistening mucosa and shows no grossly visible lesions/masses. The attached adrenal gland is diffusely enlarged, grossly appears to encroach on to the kidney, with no grossly visible invasion and shows, variegated and hemorrhagic cut surface.. Examination of the peri renal fat reveals no grossly visible nodes/masses.. Examination of the soft tissue and fat around the adrenal gland shows 9 tan-white to tan- pink, firm to hard nodes, 0.3 x 0.2 x 0.2 cm to 1.5 x 1.3 x 1.2 cm. Gross pictures of the specimen taken and specimen submitted for procurement.. Representatively submitted in 27 cassettes as follows: B1-- Ureter & blood vessels B2-B5 - sections of kidney including renal pelvis. B6-B7 = sections of kidney with attached adrenal gland
+
+--- Page 2 ---
+B8-B20 = random sections of the enlarged adrenal gland B21-B22 = random sections of the perirenal fat B23-B27 = nodules near the adrenal gland (B23 - 5 nodules, B24 - 2 nodules, B25-B27 - bisected single nodes) B28-B32 = additional sections of tumor and capsule C. PARA AORTIC LYMPH NODE Received fresh with patient's identification and designated "parotid lymph node" is a tan-. white to tan-pink, fibro fatty soft tissue fragment, 4.4 x 4.2 x 1.9 cm. The attached fat. measures 2.2 x 3.2 x 0.8 cm in aggregate. The specimen is inked with black ink and the cut section reveals 2 tan-pink, soft to firm lymph nodes, 3.2 x 2.2-1.2 and 3.8 x 2.3 x 2.1 cm, grossly appear to be matted. Examination of the attached fatty tissue reveals a tan- pink, firm to hard possible lymph node, 1.2 x 0.9 x 0.6 cm. Representative section of the. matted lymph nodes and the bisected, entire smaller lymph node submitted in 4 cassettes. as follows: C1-C3 - full-thickness section of the matted lymph nodes, C4 = bisected smaller lymph node. D. RIGHT LOWER LOBE LUNG WEDGE RESECTION Received fresh with patient's identification and designated "right lower lobe lung wedge resection" is a lung wedge, 35.8 g, and 9 X 4.5 x 3 cm. Frozen section analysis was performed and reported as poorly differentiated carcinoma, favor metastasis. The pleural surface is tan-pink without any grossly visible lesions. The stapled margin is. inked blue and the pleural surface is inked black. Serial sectioning of the specimen after removal of the stapled margin reveal a tan-white, firm to hard nodule, 1.5 x 1.5 x 1 cm, seen located 1 cm from the resection margin. Representatively submitted in 6 cassettes as follows: D2-D3 - sections from the nodule D4-D5 = sections from the adjacent lung parenchyma D6-D7 = sections from the normal appearing lung parenchyma E. RIGHT LOWER LOBE NODULE/WEDGE #2 Received fresh with patient's identification and designated "right lower lobe nodule/wedge #2" is a lung wedge, 2 g, 4.2 X 1.2 x 0.3 cm. The pleural surface is tan- pink without any grossly visible lesions. The stapled margin is inked blue and the pleural. surface inked black. Serial sectioning of the specimen after removal of the stapled margin reveal a tan-white to tan-pink, area 0.3 x 1.2 cm seen located 0.2 cm from the resection margin. Submitted entirely in 3 cassettes, E1-E3. F. RIGHT MIDDLE LOBE NODULE/WEDGE Received fresh with patient's identification and designated "right middle lobe nodule/wedge" is a lung wedge, 35.8 g, 9 x 4.5 x 3 cm. The pleural surface is tan-pink without any grossly visible lesions. The stapled margin is inked blue and the pleural
+
+--- Page 3 ---
+surface is inked black. Serial sectioning of the specimen after removing the stapled margin reveals a tan-pink to tan-white, rubbery, firm to hard nodule, 1.1 x 0.9 x 0.3 cm is seen located 1 cm from the resection margin. Representatively submitted in 6 cassettes as. follows: F1-F2 = sections from the nodule F3-F4 = sections from the adjacent lung parenchyma F5-F6 = sections from the normal appearing lung parenchyma DIAGNOSIS: A. BONE, 10TH RIB, EXCISION: - BONE AND BONE MARROW SHOWING TRILINEAGE HEMATOPOIESIS. - NO MALIGNANCY IDENTIFIED. B. LEFT KIDNEY AND ADRENAL GLAND, NEPHRECTOMY AND ADRENALECTOMY: ADRENAL GLAND: - ADRENAL CORTICAL CARCINOMA, 126 GRAMS. - TUMOR SIZE: 13.5 X 9.5.X 8.5 CM - 8 MITOSES/10 HPF WITH ABNORMAL MITOSIS - PROLIFERATION INDEX (KI67): 10% - TUMOR FOCALLY INFILTRATES THE PERIADRENAL ADIPOSE TISSUE AND MULTIPLE DISCREET PERIADRENAL TUMOR NODULES - PROMINENT TUMOR NECROSIS IS PRESENT. - CAPSULAR INVASION IS PRESENT - CELLULAR PLEOMORPHISM: MODERATE - VASCULAR INVASION: INDETERMINATE. - TUMOR IS 1 MM FROM THE INKED MARGIN OF RESECTION. KIDNEY: - NO INVASION OF KIDNEY BY THE ADRENAL TUMOR. C. LYMPH NODE, PARA AORTIC, EXCISION: - POSITIVE FOR MALIGNANCY (3/3). D. LUNG, RIGHT LOWER LOBE, WEDGE RESECTION: - METASTATIC CARCINOMA CONSISTENT WITH ADRENAL PRIMARY. - TUMOR LOCATED 1 CM FROM THE PARENCHYMAL MARGIN E. LUNG, RIGHT LOWER LOBE NODULE, WEDGE RESECTION: - METASTATIC CARCINOMA CONSISTENT WITH ADRENAL PRIMARY - TUMOR LOCATED 0.2 CM FROM THE PARENCHYMAL MARGIN F. LUNG, RIGHT LOWER LOBE NODULE, WEDGE RESECTION:
+
+--- Page 4 ---
+- METASTATIC CARCINOMA CONSISTENT WITH ADRENAL PRIMARY - TUMOR LOCATED 1 CM FROM THE PARENCHYMAL MARGIN SUMMARY OF IMMUNOHISTOCHEMISTRY/SPECIAL STAINS Material: Block B12 Population: Tumor Cells Stain/Marker: Result: Comment:  MIB1-Ki67 10 % Positive Cells  INHIBIN-ALPHA  Positive Focal A103,MELAN-A  Positive Focal, Weak  CHROMOGRANIN A  Negative  S-100  Negative CD 10  Negative The interpretation of the above immunohistochemistry stain or stains is guided by published results in the medical literature, provided package information from the manufacturer and by internal review of staining performance and assay validation within the. Immunohistochemistry Laboratory of the The use of one or more reagents in the above tests is. regulated as an analyte specific reagent (ASR). These tests were developed and their performance characteristic determined by the. Department of Pathology Laboratory at They have not been cleared or approved by the U.S. Food and. Drug Administration. The FDA has determined that such clearance or approval is not necessary.  Special stains and/or immunohistochemical stains were performed with appropriately stained positive and negative controls. ADDENDUM: Frozen section results were omitted for part D and are as follows:. INTRAOPERATIVE CONSULTATION DIAGNOSIS: FSD: Lung, right lower lobe, resection: Poorly differentiated carcinoma, favor. metastasis. Called to the O.R. W 30||3
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diff --git a/output/text/406856da-0ba9-45a9-922c-c92acb4200a3.txt b/output/text/406856da-0ba9-45a9-922c-c92acb4200a3.txt
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index 0000000000000000000000000000000000000000..05b60aaabc2247fd977096af09bc670366789cc6
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+UUID: FBA8AE9E-3A6A-43EF-A780-63A28FD91032 tcgA-22-A939-01A-pr Redacted Pathology Report Cenderi Service Received: Reported: Sunnizctng Phyatciang Pathologsst Intraop patholog:at : ICD O-3 Perrorm.ng Prysician: CLINICAL HI STORY NONE CIVEL. 8q68|3 FREOPEHATIVE DAANCSIS LEFT SXNAG MASS. C64.9 SRECIMEN TYPEISI AITHRID GROSS ONLY ) 4/28|1y BLEFT ADRENAL GLAND PHRITLMORAL FAT D: LEFTRRNAL TUMOR FS LEVT PENAL TUMOR FENAL MARGIN LEFT XEDIALRENAL MASS FS FINAL DIAGNCSIS: A. BONE,1ITH RIE,PARTIAL RKSECTCN Tartion pr unrgzarkable rib igross diagnaeisl. E. AIRENAL CLAND, LEFT,ADRENALECMY Nosular coxtical pyperplxaia, puitiple noduies, largest i.7 4o. No eyidence. ot sallgnancy C. PERITUMORAL FAT, BIOPSY Waacularszen adipose ttssue, negacive tor maignancy D. RENNL TUMCR.LEFT UPPER PCLEPARTIAL NRPHRECCMY: Fapiliary renal cell.carcinoms. typel. msltsrccal, mumorzThxe rodules-1.0m.0.7n0.3cn. Renai capouie canpresend. but negstive ror tuncr. Surgica rasecticn margns, regative Ior malignancy Suzroundany renal parencnyma copreseed and wttn glcs.erlosclexosie chronic nterattlal inrlammatcn and rocal rtcroais. coMmaNrs Histclogic sections ahows tumor ccmpoeec predominantly or tubules iined cy c.aboidal.celiemanyorwnich nave cleax.cytcplasm. Rare papillation ts roted. Oecasional Ioan celis are seen, and,the,atrons showa mucin producticn and focal epandle cells.Necroais and stgniricant mitotic activ.ty are.not seen..Immanonissochemistry atalns perrorned on blocx Di ehow cuzor celts to be poaitive tor ckt snd vmantin, and negative ror Axacr.A colloida iron atatn nighlignts tne stromal ucin. The immurostainirg protiie ravore a papiiiary rensl. celi carcinsra, -ype I. LEFT.HENAL TUMOR FINAL MARGIN EXCISICN No evidence.or nalignancy. MEDIAI RENAL MASS, LEFT,PARTAL NEPHRECTCMY: Papiilary renal cell carcinoma, type 3 rumor stzer 10x10x0.c Surgical. asecton marginanegative.ror maliguancy KEY PATHOLOGICALFINDINGS Tumor type Papillary renal cell cardinoma, type 1, molttral Nuclear grade: Lcw.grade Fattern crgrowth Fredominantly curular. upperpole 1 ncduleg-4.c,07cm0.3 c
+
+--- Page 2 ---
+Madtal1.0x1.0x0.cm. Renal. capsule Anvasion: Nene Isentitied.. Invaaion o CerccaCaacla None identlries. Penal vetn invaaton: Not exaatned. Surgical marmine: Negat ive tor maxignancy. Hon nccplastic kidney Cort:cal. comprassion, glomeruioaclerosia, ir.terstitia. Inclammatton..Iocat taterstitial ribrcais. Adrensl.giand: Noduiar cortica! nyperpiaals, negative tor malignarcy. Lymph rodes: None exazined. Fatnologic etage 13NXXX the attending pithozogist, perscraily reviewed tre entire. patniogy case and rendered t.ne kinal aiagnosia. nientronicaiiy signeg out ry OTHKR RELATRO CLINICAL DATA: NA INTRAOPERATIVE DAGNOSTS: FSEL. LEFT AENAL TUMOR, LEFT LPPER FOLE: Penal cell darcnooa, turther ctassirication derer tor permaent. PSH.. PNAL MAPGINLEFT HERAL.TMOR Margnn ie nsgative tor cal!gnancy:. FSFL. LEFT MEDIAL RENAL MASS: Panal cell carcinona, turt ner clsssiricar ton, deter ror permanent.. CoMManT Thie frozen section agrosts/resuit wss.cssmunicated to and repeated back by have perrorr.ed sre intraoperative cnaultat:on ans issuen the above diagncaes. CRCSS DESCRIFTON: A. The epecimen i9 received rresh in 6. containera. Specimen.A s lateled aiisn rin The specinen coca:sts. ot a.grosa recognizsbie portioh or rib zeasuring.5.0.cm n lergth wlth urremarkable.resection sargin. There ia nall amount ot.adjscent to riba auxrace tan, paa yelicw'te tan, red-trom, aott co nubbery tissue. ine apecimen is tor gross araiysis cnly.. Specimen a is iaraleu iost aarenal gtand" The specinen conaista ot 2a.0 g srenal gland, whicn measures7.0x 3.0x 1.0 cm. Thereis.a zoderateamount ot aajacent to adrensl gland tan psle yellow sort lotulated aipose cissue wnicr is rangirg rrom c.1 to I.o gm in thtexress.. The adrenal giand :s serially sectioneu to revpal3 irregular tocvoid rutbery,1l-derined sumor maasea rargingrrom D.sto 1.0 cn in gxeatest ulmenslon Tns tumprs are Iccated in the sedulla or tne sdrenal giand. Ihe cut surtaces ot the tumors are nonogenous, tan, pale yellow'to tan-orange. withct evidenceor necrosis br hesorrnage. Tne remaining.tlaeue ot tre aureral jland ie groaslyunrenarkable. Pepresentative.secticns ot tne specimen are auomisted to sne Tiasue procurerent Laborstory. Repreaentativa secticns or the specimensresurited in5 c3ssetteeasolcws 1-3 Representative sectlors.o tne tumor nodules 04-95 Representative gectiong ot che jrossly
+
+--- Page 3 ---
+unremarkabla.adrenal. gland. Specimen C ta sareled *peritusoral nead. The specisen cocsists.bta singie, unoriented Lragzent or Ean. pale yeliow to tan-pinx. tocaily hemorrh3gid ietuiated sdipose tisaue.nessuring 23.x 6.5 x0.8 cm. Tne specimen 1s serialiy aectioned to reveal a groesly unremarkable cut surtace, No tiesue is.autmitted to the Tissue Procuresent Laborstory: Papresentative sectiona or cne apecisen.are D. Specimen.D is lanaled *art renal tumcr, lert.upper pole,.diagnoais plus trozen aection.or Inked area* Tne.specimer ccnsiets c a paxtial nepnrectcny apecimen whicn Ia. measur:ng s.0 x 4.d x/s.0 cm. There is a moderate arount or perinepnrie adipose tiasueajicent tosre capsule, wnich is rarging tron O.i to 0.6 c n Chicknose. Prier to sectioning, the specimen :a tnxed as roiicws: Capsule and resectton sargin or Blue che pertnepnric adiposetisaue Parencryzai resect Lon sargin ci the apecimen The spcc:menis aerially.secstsnad to ravesl an irrogular to oyoid, tli-der:ned, nubnery cumor cons which ia measuring t.0.x 3:7 x.3.? cm. The tumor is suiging. but. does noc appear to extend tnrougn tne renal capsuie ana within o.i cs or the. clbsest parinephric adipose tasue margin  Tne tumor is 0.zc rrom che cIcgest pareccnysal reaectior nargin peresentatiye aection ct tre tumor witn cloaest parenchysal resection nargin eutmittes cor.trozen sectton aaFsn. The cut surrace dr the Lunor ia tan pink, cocai y nemorrnagie, wutrout evidenre.or necroete. on. section:ng tne remaining renal parercnyma a asngie oyoid.aatellice tumor dcsule is sdentiled meaeuring up to.Q.7 cm Jn greatestdtmensicn. Tns tumor nodule is 0.3 trom the cIcaest irked parenchymal resection margn. Representatave.scctions ot the specmen.suraittcd ta tne r:ssue Frocuresent Laboratory. Representative aectics o theapecimen abmitted in.s casaettes as foliowe D1-D3 Tumor buiging capsule D-D Gatallite tumor nodile with cssest parenchymal resectien margn. Specinen E is isceled *rinsl.sargin.(corresponds.wich inkea area ot tumdr sert renal susor*, ine spec:men consists ot an Arreguiar, unoriented tragment or can, red-brown rubbery tissue meaeuring 1.0 x 0.5 x.0.1 c wnicn :s submitted entirely rrtroen gect:cn 3s Fsk. Epcimen F is lateled *lect medial renal mass. ne spacimen consists o3 Fartial. nepnrectcmyspecimen seasuring.7x 1.5x 15 cm. The parenchymal resecticn msrgn is groasly unremarxatie ind tnxec black, anda possblo capsule 1a inxed bueTna specien ia aerially sectioned to:royesl antrrenular to cvald 1llderined partliy solid partially systi cumor rodalewncn ls meaeuring  x 1.0  3.3 cm ans is: o.a cm rros tne closest parencnyeal resection margin. Representative'sectione or tte specimen is aucmitted ror rxozen scctionaa Fsr. Representative sectiors or the.specimen are submitted totnn TissueProcurerent Laboracry-Tne remainsnn tiseue 1s surmltted in  casaettesFir 13/14 Diagnosis Case is {circle QUAYEED
\ No newline at end of file
diff --git a/output/text/40a9a21d-59c7-47a4-92f1-601541ff6436.txt b/output/text/40a9a21d-59c7-47a4-92f1-601541ff6436.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1f3f1cfd1b35bbe7d49c86472aa2de240eff4af3
--- /dev/null
+++ b/output/text/40a9a21d-59c7-47a4-92f1-601541ff6436.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1cp-0-3 Sit: brast,Nos c5o.9 h 8/7/1 Final Diagnosis Breast, left, total mastectomy: Infiltrating lobular carcinoma, focal solid variant, Nottingham. grade II (of III) [tubules 3/3, nuclei 1/3, mitoses 2/3, Nottingham score 6/9], forming a 11.5 x 7.0 x 6.0 cm mass extensively involving the breast [AJCCpT3]. Lobular carcinoma in situ with focal intraluminal necrosis is present. The tumor does not involve the nipple, overlying skin, or underlying chest wall. All surgical resection margins, after re-excision of the deep margin, are. negative for tumor (minimum tumor free margin, 0.8 cm, deep margin).. Lymph node, left axillary sentinel, biopsy: One (of 1) axillary sentinel lymph node is positive for metastatic carcinoma with extensive involvement of the subcapsular sinus [AJCCpN1(sn)]. Immunohistochemical cytokeratin stain was performed on the paraffin embedded sentinel lymph node tissue and confirms the H&E impression. Extranodal extension is not present.. Lymph nodes, left low axillary, dissection: Multiple (17) axillary lymph nodes are negative for  metastatic carcinoma. Seen with Dr. UUID: 5411AC07-09E4-40C3-844F-2DFAA216D947 TCGA-AR-A2L-01A-PR Redacted 57t
\ No newline at end of file
diff --git a/output/text/40b3aa1e-c8b1-4eb9-9ef7-9c6dd012118a.txt b/output/text/40b3aa1e-c8b1-4eb9-9ef7-9c6dd012118a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d8288bddac72ce86f553216764f99e75b8e71ce0
--- /dev/null
+++ b/output/text/40b3aa1e-c8b1-4eb9-9ef7-9c6dd012118a.txt
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+
+--- Page 1 ---
+UUID:CEE5BD08-0FC9-4780-A5CB-A0962A3BE721 Redacted Gender: Male DOB: Race: Report Date: - Surgical Pathology Report FINAL PATHOLOGIC DIAGNOSIS A. Right distal ureter; biopsy: - Segment of ureter, no evidence of tumor or dysplasia. B. Left pelvic lymph nodes; dissection: - Two of eight lymph nodes positive for metastatic urothelial carcinoma (2/8) with extranodal extension. C. Right pelvic lymph nodes: - Two of thirteen lymph nodes positive for metastatic urothelial carcinoma (2/13) with extranodal extension. D. Left distal ureter; biopsy:  - Segment of ureter, no evidence of tumor or dysplasia.. E. Left pelvic lymph nodes; dissection: - One of eight lymph nodes positive for metastatic urothelial carcinoma (1/8). F. Bladder, prostate, seminmal vesicles, vas deferens; radical cystoprostatectomy: - High-grade urothelial carcinoma, see pathologic parameters. - Ulcerated mucosa with marked granulomatous reaction consistent with therapy effect. - Adenocarcinoma of prostate, see below. Urothelial Carcinoma 1cd-o-3 1. Tumor type: Urothelial carcinoma Carcinoma,unthelic},NO5 2. Grade of tumor: High-grade 3. Depth of invasion: Extravesicular fat 8120|3 4. Tumor distribution: Sie' Solitary, 3.8 cm in size Pah: b|acker nos left lateral wall posterior wall C0).9 5. Ureteral Margins: Negative CQcr: bladder,wal1, Jokia1 6. Distal urethral margin: Negative 7. Lymph nodes: Five of 29 lymph nodes positive for metastatic urothelial C67.z carcinoma 8. pTNM: pT3a, N2, MX 4-912 Radical Prostatectomy Pathologic Parameters 1. Gleason' s Grade: 6 (3+3) 2. Perineural invasion: Absent 3.  Tumor location: Peripheral zone - right 4. Tumor Volume Estimate: 1%
+
+--- Page 2 ---
+5. High-grade P.I.N.: Multifocal 6. Seminal Vesicles: Negative for tumor 7. Fibromuscular capsule: Tumor confined to the prostate 8. Peripheral margin: Negative for tumor 9. Distal (apical) Margin: Negative for tumor 10. Proximal (basilar) margin: Negative for tumor. 11. Regional Lymph Nodes (right and left): Negative for prostatic tumor. 12. pTNM:pT2a,N0, MX xxx [], m.d. Interpretation performed by the Attending Pathologist and reviewed with the Resident or Fellow. Electronically Signed Out by [] M.D. Clinical History: The patient is a  year-old male with bladder cancer who undergoes radical. cystectomy and bilateral pelvic lymph node dissection.. Specimens Received: A: Right Distal Ureter B: Left Pelvic Lymph Nodes C: Right Pelvic Lymph Nodes D: Left Distal Ureter E: Left Pelvic Lymph Nodes F: Bladder, Prostate, Seminmal Vesicles, Vas Deferens. Gross Description: The specimen is received in six containers, each labeled with the patient name and medical record number. A. Part A is further designated as "1. right distal ureter." Received fresh. for frozen section is a 0.7 cm segment of pink-tan tissue with a 0.5 cm lumen, consistent with a ureter. The specimen is serially sectioned and partially submitted for frozen section, which is read as "segment of ureter, no evidence of tumor and no dysplasia" per Dr. []. The remainder of the specimen is submitted in cassette A2. B. Part B is further designated as "2. left pelvic lymph nodes." Received fresh for frozen section is a 4.0 x 3.0 x 1.0 cm aggregate of pink-tan,. fibrofatty tissue. Two lymph nodes are submitted for frozen section and read as "one lymph node with microscopic focus (<2 mm) of metastatic urothelial. carcinoma, another lymph node is benign, reactive" per Dr. [1 The frozen section remnant is submitted in cassette B1FS. The remainder of the specimen is. submitted entirely as follows: B2:  one large lymph node, bisected B3: one large lymph node, bisected B4: three small lymph nodes B5-B6:  remaining fibroadipose tissue C. Part C is further designated as "3. right pelvic lymph nodes." Received fresh and placed in formalin is a 7.0 x 5.0 x 2.0 cm aggregate of fibrofatty
+
+--- Page 3 ---
+tissue. Multiple lymph nodes are identified upon dissection, the largest measuring 4.0 x 3.0 x 0.2 cm. The lymph nodes are submitted as follows: C1-C11:  one large lymph node in each cassette, some are bisected and/or serially sectioned C12: four lymph nodes D. Part D is further designated as "4. left distal ureter." Submitted fresh for frozen section is a 0.9 cm length of pink-tan, rubbery tissue with a 0.6 cm external diameter and a 0.3 cm lumen. The specimen is bisected and submitted for frozen section. The frozen section is read as "ureteric segment with no evidence of tumor and no dysplasia" by Dr. [] The remainder of the frozen section is submitted in cassette D1Fs. The remaining specimen is submitted in cassette D2. E. Part E is further designated as "5. left pelvic lymph nodes." Received in formalin is a 5.0 x 4.0 x 3.0 cm aggregate of soft, fibrofatty tissue, which is dissected to reveal multiple lymph nodes. The specimen is submitted as follows: E1-E4: one large lymph node in each cassette, bisected E5: four possible lymph nodes. E6: four possible lymph nodes F. Part F is further designated as "6. bladder, prostate, seminal vesicles, vas deferens." Received fresh and placed in formalin is a 9.5 x 8.0 x 5.5 cm cystoprostatectomy specimen with attached mesenteric fat. The attached prostate measures 4.0 x 3.8 x 2.9 cm. The left seminal vesicle measures 4.0 x 1.5 cm and the left vas deferens measures 9.5 cm. The right seminal vesicle measures 3.5 x 1.8 cm and the right vas deferens measures 9.0 cm. The entire specimen is inked blue. The prostate is opened along the urethra and reveals tan-brown, wrinkled mucosa. The bladder itself measures 6.0 x 5.0 x 3.8 cm. The right ureteral stump measures 2.4 cm and has a patent lumen. The left ureteral stump measures. 2.0 cm and also has a patent lumen. There is a 3.8 x 2.6 cm ulcerated, red-tan lesion on the left posterolateral wall, reaching from the left trigone to the bladder dome. Grossly, the mass extends into the prostatic urethra and the left half of the prostate. The right ureteral orifice at the trigone can be probed,. the left cannot. Sectioning of the mass shows gross tumor invasion of the mucosal wall, 1.0 cm from the deep margin. The mucosa of the anterior wall is glistening and pink-gray in color. Sectioning of the prostate reveals. trabeculated, pink-tan periurethral nodularity. No lesions are grossly identified. Representative sections are submitted as follows: F1: distal resection margin. F2-F4: representative section of lesion from left posterolateral wall F5: representative lesion in bladder dome F6: right posterior bladder wall. F7: right anterior bladder wall. F9: anterior bladder wall F10: right inferior bladder wall. F11-F15: representative sections of the left prostate F16-F20: representative sections of the right prostate F21: seminal vesicles and vas deferens F22: distal ureter F23: distal vas deferens
+
+--- Page 4 ---
+XX [] M.D. Intraoperative Consult Diagnosis: A1FS. Right distal ureter: Segment of ureter, no evidence of tumor and no dysplasia. B1Fs. Left pelvic lymph nodes: One lymph node with microscopic focus (<2 mm) of metastatic urothelial carcinoma, another lymph node is benign, reactive.. D1FS. Left distal ureter: Ureteric segment with no evidence of tumor and no. dysplasia.
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diff --git a/output/text/40b931b2-9faf-4cdf-bec7-01750f04166a.txt b/output/text/40b931b2-9faf-4cdf-bec7-01750f04166a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..43101d222959d6a958739b5e4bc71573b9072a5d
--- /dev/null
+++ b/output/text/40b931b2-9faf-4cdf-bec7-01750f04166a.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+/cs-0-3 Carcnima, nifitrating duct, nos 9500/3 SitE : brwt Nos C50.9 1/28/11 Pathology Form Specimen Information Collected by: Date: Time: Preserved by: Date: ime: TSPECIMENTYPE #of sample piovided).  Frozen Paraffin Block  Blood/Serum/Plasma Slide Diseased Normal Diseased  Normal Diseased Normal Diseased  Normal x + Time to LN2 Time to Formalin Time to LN2 4d. min do min min  ASEEPATHOLOGICALDESCRIPTIONASORRA Primary Tumor. Organ Size Extension of Tumor Distance to NAT Reeu! 3 xL x4.Scm NO 12 cm Lymph Nodes Location # Examined # Metastasized Axilla Distant Metastasis Organ Detailed Location Size NO Pathological Staging NA M.0 pT 9 Stage: LR Notes: UUID: B6428344-2D68-404B-AD9F-CA6E0B0552B2 TCGA-C8-A12U-01A-PR Redacted 4
+
+--- Page 2 ---
+#:1 Microscopic Description www.HitoogicaPatnw.wwww.. Structural Pattern + Cell Distribution +  Streaming Diffuse Storiform  Mosaic  Necrosis  Fibrosis  Palisading Lymphocytic Infiltration Cystic Degeneration Vascular Invasion + Clusterized Bleeding Myxoid Change Alveolar Formation Psammoma/Calcification  Indian File oCelllarDifferentiation  Sarcomatous + Lymphomatous + - Adenomatous  Squamous + Round Cel! Large Cell  Squamoid Cell Glandular cell Fibroblast Small Cell Spindle Cell Cell Stratification Osteoblast RS Cell/RS Like  Keratin Secretion  Lipoblast Inflam. Cell Intracyt. Vacuole  Desmosome Myoblast Plasma Cell Pear!  Gland formation +  Poor Well x Moderate Cellular Differentiation: mNuclear Appearance 1 II III 0 Nuclear Atypia:  Aniso Nucleosis + Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell +  Mitotic Activity + Nuclear Grade: Value Date Result Marker  Negative   Positive ER PR Negative  Positive  Negative  Positive Her-2/neu  Negative  Positive B-Cell Marker  Negative  Positive T-Cell Marker Other: Negative _ Positive  Negative  Positive Other: Final Pathology Report Inlasue Ductf Carciuma Histological Diagnosis: Grade: (1 Comments: Date Pathologist Principal Investigator
+
+--- Page 3 ---
+CONSOLIDaTED DIAgnOsTIC PATHOLOgy fORm* Microscopic Appearance: 1.: Histological pattern: CELL DISTRIBUTIONS  Diffuse STRUCTURAL PATTERN Mosaic X IStreaming Necrosis Y  Storiform Lymphocytic Infiltration Fibrosis Vascular Invasion Palisading Clusterized d Cystic Degeneration Alveolar Formation Blceding WMyxoid Change Indian File Psammoma/Calcification 2. Cellular features: Squamous Adenomatous Squamoid Cell  Sarcomatous Glandular cell Lymphomatous Round Ceil Spindle Cell Cell Suratification  Large Cell Y Fibroblast Small Cell  Keratin  Secretion Osteoblast Desmosome RS CeIVRS Like Intracyt. Vacuole  Lipoblast Inflam. Cell Pear!  Gland formation Myoblast  Plasma Cell Otherwise Specified: Dj 70 pr30T D3 5OZ Py 3oZ 2.Cellular Differentiation: Well Moderately Poor Nuclear Atypia: Nucicar Appearance Aniso Nucleosis Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity Nuckar Grade Histological Diagnosis: InplTra/ay uetal Ca Lirmma. N0s, Co-3 M : Casinexs Meta+eeized to N Comments: Date  PATHOLOGIST STAFF FOR RESEARCH USE ONLY).E INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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diff --git a/output/text/40e2a739-89e6-49fe-8b39-2b29e5201f1b.txt b/output/text/40e2a739-89e6-49fe-8b39-2b29e5201f1b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3e1077f49094a36405083aa526a20e812133e7d3
--- /dev/null
+++ b/output/text/40e2a739-89e6-49fe-8b39-2b29e5201f1b.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Department of Pathology UUID:6F774CEE-19EF-4C9F-BC85-CD929664A3FD TCgA-P4-AAVM-01A-PR Redacted Tissue Source Site (TSS) #: Patholgy Accession No: Patient ID: Normal Sample ID: Pathology Report DIAGNOSIS (A) LEFT KIDNEY AND ADRENAL AND PARA-AORTIC LYMPH NODE: PAPILLARY RENAL CELL CARCINOMA (2.3 X 2.0 X 1.5 CM), TYPE 2, FUHRMAN NUCLEAR GRADE 3, CONFINED TO THE KIDNEY. Multiple renal adenomas. Renal cortical cysts. Renal parenchyma with multiple foci of calcifications and focal fibrosis. Margins of resection (vascular, ureteral and perinephric adipose tissue) free of tumor. Adrenal cortical adenoma (4.9 x 4.5 x 3.1 cm, 43.8 grams). GROSS DESCRIPTION (A) LEFT KIDNEY AND ADRENAL AND PARA-AORTIC LYMPH NODE - A left radical nephrectomy specimen (overall 15.5 x 8.2 x 6.3 cm) including left kidney (10.5 x 6 x 4.1 cm) and adrenal gland (6 x 4.5 x 2.3 cm). The adrenal gland weighs 43.8 grams and appears mostly replaced by a well-circumscribed, golden yellow, septated. hemorrhagic mass (4.9 x 4.5 x 3.1 cm), extending to within 0.1 cm of the soft tissue resection margin, and to within 2.7 cm of the. vascular resection margin. A pinpoint (less than 0.1 cm diameter) golden yellow nodule is present on the surface of the clamped adrenal vessel, and is located 0.3 cm from the vascular margin. Scant unremarkable adrenal tissue is identified, with golden brown cortical tissue and brown medullary tissue. Tumor tissue is submitted for possible electron microscopic studies.. The kidney contains a 2.3 x 2 x 1.5 cm well-circumscribed red brown, hemorrhagic mass at the anterior mid aspect,. abutting the renal sinus and renal pelvicalyceal system. This tumor nodule is at least 0.8 cm away from the soft tissue resection. margin, and widely free of the renal vascular and ureteric margins. There is no involvement of perinephric adipose tissue, rena! sinus adipose tissue, renal vein or Gerota's fascia. Multiple thin-walled cortical cysts containing hemorrhagic, opaque fluid are present within the cortex of the kidney. Additionally, the papillae appear yellow-white and shrunken. No other masses or lesions identified within the adjacent kidney parenchyma. The pelvicalyceal system is smooth and devoid of any lesions. No lymph nodes are identified in the hilum of the kidney. INK coDE: Black - Gerota's fascia and closest adrenal soft tissue resection margin. SECTION CODE: A1, adrenal vascular margin; A2, yellow nodule adjacent to adrenal vessel; A3-A6, adrenal tumor and closest soft tissue resection margin; A7, adrenal tumor and unremarkable adrenal gland; A8, kidney, hilar margin; A9, A10, tumor in relationship to perinephric fat; A11-A13, tumor in relationship to renal sinus; A14, additional section of tumor; A15-A17, kidney cyst; A18-A20, renal parenchyma with fibrotic papillae. *IOA/DX: RENAL PARENCHYMAL TUMOR (GROSS EXAMINATION). CLINICAL HISTORY ICD-O-3 sreurono, yeepllary nna! Left renal mass. 826013 SNOMED CODES Yudny NoS C44.9 T-71000,M-83123, M-Y7343, T-B3000,M-83700,M-88700 S 5/19/14 4
\ No newline at end of file
diff --git a/output/text/40ed1086-b0a8-43b1-8bff-844a4abf6b87.txt b/output/text/40ed1086-b0a8-43b1-8bff-844a4abf6b87.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4c3ca24741837c504cba2e75ff7dd71315d68f4f
--- /dev/null
+++ b/output/text/40ed1086-b0a8-43b1-8bff-844a4abf6b87.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Pathology Report ***** MODIFIED REPORT - REVIEW ADDENDUM SECTION ***** ADDENDUM DIAGNOSIS RIGHT KIDNEY AND ADRENAL: RENAL CELL CARCINOMA, CHROMOPHOBE TYPE (SEE COMMENT) COMMENT The purpose of this addendum report is to classify this renal carcinoma based on the immunohistochemical pattern. The tumor is positive for cytokeratin 7 and CD117 and shows weak diffuse cytoplasmic positivity for CD10.. DIAGNOSIS (A) RIGHT KIDNEY AND ADRENAL: RENAL CELL CARCINOMA (8.5 CM IN MAXIMUM DIMENSION), FUHRMAN GRADE 3 (SEE COMMENT).E TUMOR IS CONFINED TO THE KIDNEY. INVASION OF INTRAPARENCHYMAL HILAR VESSELS IS PRESENT Extraparenchymal hilar vessels are free of tumor.. Margins of resection are free of tumor. Chronic interstitial nephritis and glomerulosclerosis in kidney adjacent to tumor. Unremarkable adrenal gland. COMMENT Immunohistochemical stains are pending and the results will be reported in a supplemental report.. GROSS DESCRIPTION (A) RIGHT KIDNEY AND ADRENAL - A radical nephrectomy specimen (19.0 x 12.0 x 7.0 cm), including the right kidney (13.0 x 5.5 x 3.0 cm), segment of the renal artery, the renal vein and ureter (14.0 cm in length and averaging 0.4 cm in diameter) in the adrenal gland (6.0 x 2.0 x 1.5 cm). There is an 8.5 x 8.5 x 6.5 cm well circumscribed tumor arising from the anterior surface of the kidney, involving the upper. and middle pole. The tumor pushes into the perinephric adipose tissue and extends to within 0.2 cm from the inked Gerota's fascia in an area marked by Dr.  as abutting the colon. The tumor is centrally cystic (approximately 60% of the tumor). This cyst is filled with brown opaque fluid. The wall of the tumor consists of lobulated brown, friable tissue which is surrounded by a thickened fibrous capsule. The tumor pushes into but does not appear to invade the renal sinus and does not appear to invade the. perinephric adipose tissue or the renal vein. The adjacent kidney parenchyma is unremarkable. No additional masses are identified. The pelvicalyceal system is smooth and devoid of any lesions. No lymph nodes are identified in the hilum of the kidney. Cross sections of the right adrenal gland show unremarkable cortex and medulla. Portions of the tumor have been submitted for possible electron microscopy, on hold. The tumor and normal renal parenchyma are submitted for research purposes. INK CODE: Blue - Gerota's fascia/area marked by surgeon as adherent to colon. SECTION CODE: A1-A3, closest approach mass to inked Gerota's fascia/area marked by surgeon as adherent to colon,. frozen section; A4, vascular and ureter margins; A5, representative of adrenal gland; A6-A13, representative of tumor (A6-A8 with. relationship to renal sinus; A9-A10, with relationship to nonneoplastic kidney; A11-A12, with relationship to perinephric adipose tissue; A13, additional representative section); A14, A15, no-neoplastic kidney. *FS/DX: MARGIN FREE OF TUMOR.
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diff --git a/output/text/40f1492e-d1da-4bc2-9cd5-5fee8d454e3e.txt b/output/text/40f1492e-d1da-4bc2-9cd5-5fee8d454e3e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d4cd1e16f1315f33c7c29d96c282d524693a2a7a
--- /dev/null
+++ b/output/text/40f1492e-d1da-4bc2-9cd5-5fee8d454e3e.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:6C520037-2A98-41CB-8362-97FFCA2AA6E2 CGA-AN-A0FY-01A-PR Redacted TSS Patient ID: Case #: DOB: Sex: Female Ethnicity (Race):. Cancer Sample Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma Date of Procurement: Anatomic Site: Left Breast Tumor location: Primary Tissue Specification: Tumor Specimen Matrix: Tissue Specimen Format: Frozen Container: cryomold Type of Procurement: Radical mastectomy Grade: 3 T Stage: 1c N Stage: 0 M Stage: 0 Treatment: none Treatment Details: n/a.  Normal Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw Matrix: Blood Specirnen Format: frozen Container: tube Date of Procurement: 1cs-0-3 cascnomu, infiItnahxy duct, No5 85ocf3 Sife: hreist,Nvs C50.4. h 10/21/11 fo/?+
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diff --git a/output/text/40f701d3-9742-4cfd-81cf-5e2db32b5741.txt b/output/text/40f701d3-9742-4cfd-81cf-5e2db32b5741.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3ec346476debafeacab76032be857ee51f3fb245
--- /dev/null
+++ b/output/text/40f701d3-9742-4cfd-81cf-5e2db32b5741.txt
@@ -0,0 +1,21 @@
+
+--- Page 1 ---
+SURGICAL PATHOLOGY REVISED REPORT 1cs-0-3 Case Number : Cecinma, mfltrutng ductl, nos 8500/3 ShH Sty: bruot, uppw ontn guaoren! c50.4 CQlF C50.9 Diagnosis: Breast, right, mastectomy 31 Tumor type: invasive ductal carcinoma with extensive fibrosis (see comment) Nottingham combined histologic grade: 2 Tubule formation score: 2 Nuclear Pleomorphism Score: 3 UUID:185FA34B-E3B4-4D4B-AF0A-1C90016CC532 Redacted TCGA-AQ-A1H2-01A-PR Mitotic count score: 2 Focality of tumor: single focus Tumor size (greatest dimension): 3.5 cm (see comment) Lymphovascular invasion: present (A8) In Situ Component: present In Situ Component type/Architecture pattern: solid and cribriform In Situ Component nuclear grade: 3. In Situ Component necrosis: none identified. In Situ Component extent/size: DCiS is present with tumor and focally away from tumor. Size is approximately 6 mm. Extensive intraductal component: Absent. The DciS comprises approximately 2% of total tumor. Nipple involvement: none identified Skin involvement: none identified Margin status: vasive component: >5 mm  Situ component: >5 mm Axillary lymph nodes:
+
+--- Page 2 ---
+Total number with metastasis: 7 Total number examined: 10 (1 from part A, 9 from part B below) Size of largest metastasis: 1.3 cm (A14, A15) Extracapsular extension: present and extends into fibrous septae of surrounding fibroadipose tissue Microcalcifications: associated with invasive carcinoma, ductal carcinoma in situ, and sclerosing adenosis Other findings:. - Fibrocystic changes with ductal epithelial hyperplasia. - Sclerosing adenosis.. - Benign skeletal muscle.. AJCC PATHOLOGIC TNM STAGE: pT2 pN2a Note: This pathologic stage assessment is based on information available at the time of this report, and is subject to change pending clinical review and additional information. B: Soft tissue, axillary contents, removal - Six of nine lymph nodes with metastatic carcinoma (6/9). - Largest metastatic focus 1.3 cm. - Extracapsular extension is present. Comment: Although two foci of carcinoma were previously identified radiologically (2.0 cm and 1.5 cm) and sampled by core biopsy, only one large focus of tumor is identified grossly in this mastectomy specimen. Gross examination has been repeated several times and additional sections submitted with no second tumor nodule identified. A second firm nodule was identified 3 cm away from the first, but microscopically it appeared to be sclerosing adenosis and this was confirmed with positive immunostaining with p63 and smooth muscle myosin heavy chain (A17). The current single focus of tumor is extremely fibrotic and measures 3.5 cm (which is equal to the two previously identified foci combined) Of the two foci initially seen, one was described as superficiai and the other deep, but they were very close to each other (10:00 and 9:00 to 10:00). The current large focus is located at 9:00 to 10:00 and extends from superficial to deep. Histologically, the tumor demonstrates morphologic features consistent with both of the previous core biopsies (predominant morphology is that of the "deep" core with some areas resembling the "superficial" core). The. different-appearing areas merge into each other and are part of the same nodule of tumor. Immunostain for e-cadherin was performed on a couple of areas that have lobular features (similar to the superficial core biopsy); it is positive, confirming the ductal phenotype of the tumor (A8, B3). Immunostain for AE1/AE3 was. performed on block B8 and confirms no metastatic tumor in that lymph node. Immunohistochemical stains for ER, PR and HER2/Neu were performed with the following results. These stains were performed on tumor that resembles the deep core biopsy, and results are similar to those from the deep core biopsy (except HER2 is 1+ instead of 0, but still considered negative). Material from an additional block (with areas resembling the superficial core) has been submitted to see if it stains similarly to the superficial core; the original superficia! core showed HER2 at 2+ and amplification by FiSH. These results will be reported in an addendum. Results:
+
+--- Page 3 ---
+Estrogen receptor ('. , clone SP1): Interpretation: Positive Computer-assisted quantitative score: 100% Progesterone receptor (' , clone 1E2): Interpretation: Positive Computer-assisted quantitative score: 12% HER2/neu (Ventana, clone 4B5, FDA-approved): Interpretation: Negative (not overexpressed) Computer-assisted quantitative score: 1+ Site: right breast Performed on block: A7. Fixation: 10% neutral buffered formalin Fixation time: 6-48 hours. Reference range: Estrogen receptor and progesterone receptor: <1%=NEGATIVE, 1-10% WEAK POsiTIVE, >10% POsiTIVE HER2/neU: O,1=NEGATIVE FOR OVEREXPRESSION, 2=INDETERMINATE, 3=POSITIVE FOR OVEREXPRESSION omment: The quantitative scores reported above were obtained using the FDA-approved 1 The control slides for this case show appropriate staining. Some of the immunohistochemical reagents used in this case may be classified as analyte specific reagents (AsR) or. research use only (RuO) reagents. These were developed and have performance characteristics determined by the. These reagents have not been cleared or.  approved by the US Food and Drug Administration (FDA). The FDA has determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for research. This Iaboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA-88) as qualified to perform high complexity clinical laboratory testing. Intraoperative Consult Diagnosis: Clinical History: with right breast cancer.. Gross Description: eceived are two appropriately labeled containers. Container A:
+
+--- Page 4 ---
+Specimen fixation: formalin. Time in fixative: 9 hours. Type of mastectomy: modified radical. Weight of specimen: 970 grams Size of specimen: 25 cm medial to lateral, 24 cm superior to inferior, and 3.5 cm anterior to posterior Orientation of specimen: Inking: lateral=yellow, anterior=blue, posterior=black. Skin ellipse dimensions: 21.5 x 16.3 cm. Nipple/areola: 0.6 cm/3.4 cm, respectively. Axillary tail: absent. Biopsy site: not identified. Discrete Mass(es): present; one large firm mass is identified. The cut surface is tan with small areas of hemorrhage and fat necrosis. The mass is well demarcated and lobular in shape.. Number of discrete masses: one Size of mass (es)/biopsy site: 3.5 x 2.9 x 1.8 cm Location of mass(es): upper outer quadrant Distance of mass/biopsy site from surgical margin: 2.4 cm from the black inked posterior margin and 4.5 cm from the. closest blue inked anterior margin.. Gross involvement of skin or fascia/muscle by tumor: absent. Description of remaining breast: The remainder of the breast tissue is predominantly yellow lobulated fat which is interspersed with delicate strands of white fibroconnective tissue.. Other remarkable features: There is an arterial graft in the subareolar breast tissue that runs from the superior to inferior aspects of the specimen. This graft is 11.7 cm long and 1.4 cm in diameter.. Tissue submitted for special investigations: tumor and normal tissue are submitted for. Addendum: On further gross examination, a second mass is identified. The second mass is approximately 3 cm medial ty the first mass. The second mass is a well circumscribed, white firm nodule measuring 1.5 x 1.0 x 1.0 cm. This mass is 7.3 cm from the nearest blue inked anterior margin, 3.0 cm from the nearest black inked deep margin, and 3.0 cm from the skin. There is no evidence of hemorrhage or necrosis associated with this mass. (Histologically, this mass is sclerosing
+
+--- Page 5 ---
+adenosis.) Block Summary:e Inking: lateral=yellow, anterior=blue, posterior=black). A1 - perpendicular sections of nipple A2 - areola, en face A3 - representative section of mass with closest black inked posterior margin A4 - representative section of breast tissue from closest anterior margin A5-A9 - representative sections of mass A10 - representative section of breast tissue from upper inner quadrant A11 - representative section of breast tissue from lower inner quadrant A12 - representative section of breast tissue from lower outer quadrant A13 - representative section of breast tissue from upper outer quadrant A14,A15 - intraparenchymal lymph node, serially sectioned A16-A18- second mass, submitted entirely from lateral to medial Container B holds a 9.5 x 5.4 x 3.5 cm mass of yellow/tan lobulated fat with associated connective tissue. This specimen is unoriented. The specimen is dissected to identified lymph node candidates and multiple lymph node candidates. are identified. The largest candidate measures 3.1 x 1.9 x 1.0 cm. Block summary:. 1,82 - largest lymph node candidates, serially sectioned B3 - one lymph node candidate, serially sectioned. B4 - one lymph node candidate, serially sectioned. B5 - one lymph node candidate, serially sectioned 86 - three lymph node candidates B7 - one lymph node candidate, serially sectioned.  B8 - one lymph node candidate, serially sectioned B9 - two lymph node candidates 810 - three lymph node candidates B11 - one lymph node candidate, bisected B12 - one lymph node candidate Grossing Pathologist: Light Microscopy: Light microscopic examination is performed by Dr.. For cases in which immunostains are performed, the following applies: Appropriate internal and/or external positive and negative controls have been evaluated. Some of the immunohistochemical reagents used in this case may be classified as analyte specific reagents (AsR). These were developed and have performance characteristics determined by the Anatomic Pathology Department, . These reagents have not been cleared or pproved by the US Food and Drug Administration (FDA). The FDA has determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for research. This Iaboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLlA-88) as qualified to perform
+
+--- Page 6 ---
+high complexity clinical laboratory testing. Signature Resident Physician:. Attending Pathologist: 1 have personally conducted the evaluation of the above specimens and have rendered the above diagnosis(es).. Procedures/Addenda: Addendum Addendum The following addendum is issued to report the results of estrogen receptor, progesterone receptor, and HER2/neu. immunohistochemical studies.. Results: Estrogen receptor () 1, clone SP1): Interpretation: Positive Computer-assisted quantitative score: 94% Progesterone receptor :. clone 1E2): Interpretation: Negative Computer-assisted quantitative score: 0% HER2/neu ( clone 4B5, FDA-approved): Interpretation: Positive (overexpressed) Computer-assisted quantitative score: 3+ (see note) NOte: This block (A5) includes areas that show morphologies similar to both the superficial and deep cores. ER and PR are. relatively homogeneous throughout the tumor, regardless of morphology. Immunostain for HER2 is heterogeneous, but staining does not correlate with any particular morphology. There is enough strong complete staining to interpret the. HER2 as 3+ (overexpressed); however, areas in this block range from no staining to strong and complete staining. Site: right breast Performed on biock: A5 Fixation: 10% neutral buffered formalin Fixation time: 6-48 hours Reference range: Estrogen receptor and progesterone receptor: <1%=NEGAT!VE, 1-10% WEAK POSITIVE, >10% POsiTIVE HER2/neU: O,1=NEGATIVE FOR OVEREXPRESSION, 2=INDETERMINATE, 3=POSITIVE FOR OVEREXPRESSION Comment:
+
+--- Page 7 ---
+The quantitative scores reported above were obtained using the FDA-approved. The control slides for this case show appropriate staining.. Some of the immunohistochemical reagents used in this case may be classified as analyte specific reagents (AsR) or. research use only (RuO) reagents. These were developed and have performance characteristics determined by the. These reagents have not been cleared or approved by the US Food and Drug Administration (FDA). The FDA has determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLiA-88) as qualified to perform high complexity clinical laboratory testing..
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diff --git a/output/text/4117b404-1bbd-4bd2-b38f-01f2c02a9a22.txt b/output/text/4117b404-1bbd-4bd2-b38f-01f2c02a9a22.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f24db0a05f2c5eba0166ef2f6706780c9a8588c1
--- /dev/null
+++ b/output/text/4117b404-1bbd-4bd2-b38f-01f2c02a9a22.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+ UUID:405B9D03-6200-4DFA-A7D1-C622D3A48AEA TCGA-A2-A3XV-01A-PR Redacted Phone Fax Name: Age/Sex: Location: Acct#: Unit#: Status: Room/Bed: Reg: Disch: Att Dr: Specimen: Received: Status: Reg#: Spec Type: SURGICAL P Subm Dr: PREOPERATIVE DIAGNOSIS i cd-o3 RIGHT BREAST CANCER ~ INVASIVE Cgrcinomg, inf 1trating duc+,NO 8 S0 3 OPERATION PERFORMED Si*: br<gs+,NOs DATE: Cs0.9 DOCTOR(S) : PROCEDURE:  MASTECTOMY, PARTIAL LUMPECTOMY, SENTINEL NODE BX 5-Z3~1Z TISSUI REMOVED A. RT AXILLARY SENTINEL NODE #1 B. RT AXILLARY SENTINEL NODE #2 C. RT BREAST D. RT BREAST DEEP AND LATERAL MARGIN GROSS DESCRIPTION RECEIVED IN 4 PARTS. A RECEIVED LABELED RIGHT AXILLARY SENTINEL NODE 1 HOT COUNT 161O IS A 3 X 2.2 X 1.2 CM PORTION OF YELLOW FATTY TISSUE WITH FOCAL BLUE COLORATION. SECTIONING REVEALS A 2.5 CM IN DIAMETER ROUNDED PORTION OF YELLOW FATTY TISSUE WHICH DEMONSTRATES FOCAL BLUE COLORATION. THIS IS SUBMITTED BISECTED IN A1 AND 2. ALSO IN A2 IS A SEPARATE FIRM AREA MEASURING O.5 CM IN DIAMETER. B RECEIVED LABELED RIGHT AXILLARY SENTINEL NODE 2 HOT AND BLUE COUNT 73768 IS A 4 X 2.5 X 1.2 CM PORTION OF YELIOW FATTY TISSUE. A 2.5 CM LYMPH NODE WITH MARKED BLUE COLORATION IS IDENTIFIED. THIS IS SUBMITTED BISECTED LABELED B. C RECEIVED LABELED RIGHT BREAST SHORT SUPERIOR LONG LATERAL IS AN OVOID PORTION OF YELLON-RED FATTY TISSUE MEASURING 6.8 X 6.0 x 3.7 CM. THE SPECIMEN IS ORIENTED BY 2 SUTURES. THE MARGINS ARE BLUE, ANTERIOR BLACK, DEEP YELLOW. A SMALL METAL CYLINDER IS FOUND IN THE MEDIAL ASPECT OF THE SPECIMEN WHICH IS THE EXTREME MEDIAL ASPECT OF A CENTRAL GRAY-PINK GLISTENING MASS WHICH HAS A NODULAR APPEARANCE. THIS MEASURES 2 X 2.7 X 2 CM IN GREATEST DIMENSION.  THE TISSUE INFERIOR AND DEEP TO THIS LESION IS DENSE TAN FIBROUS TISSUE WITH FOCAL SMALL CYSTS.  THERE IS QUESTIONABLE EXTENSION OF THE LESION TO THE DEEP AND
+
+--- Page 2 ---
+Patient: (Continued) Specimen: Received: Status: 3q# : Spec Type: SURGICAL P Subm Dr: GROSS DESCRIETION (Continued) SUPERIOR ASPECT IN THE MEDIAL AREA.  THIS LESION IS O.7 CM FRCM THE ANTERIOR MARGIN AND O.7 CM FRCM THE INFERIOR MARGIN AND 1 CM OR MORE FROM ALL OTHER MARGINS. REPRESENTATIVE SECTIONS ARE SUBMITTED AS FOLLOWS:  C1--REPRESENTATIVE PERPENDICULAR MEDIAL MARGIN, C2--REPRESENTATIVE PERPENDICULAR LATERAL MARGIN, C3--LESION FROM MOST MEDIAL ASPECT TO INCLUDE POSSIBLE SUPERIOR TO DEEP, C4 THROUGH 6--THE REMAINDER OF THE CROSS SECTION TO C3, C7--ADJACENT SECTION TO C3 TO INCLUDE POSSIBLE SUPERIOR NODULES, C8--REMAINDER OF LARGE MASS TO C7, C9--AREA DEEP TO C8, C1O--THE CLOSEST GROSS ANTERIOR AND LATERAL MARGINS. D RECEIVED LABELED RIGHT BREAST DEEP AND LATERAL MARGIN INK MARKS NEW MARGIN IS AN OVOID PORTION OF YELLOW-RED FATTY TISSUE MEASURING 6 X 5 X 1.5 CM IN GREATEST DIMENSION. PURPLE-BLUE COLORATION IS NOTED ON ONE SURFACE.  THIS IS REMARKED WITH BLUE INK WITH A PERIMETER OF BLACK INK. THIS IS SECTIONED AND SUBMITTED ENTIRELY LABELED D1 THROUGH 8.  TISSUE SECTIONS ARE PLACED IN FORMALIN AT HOURS ON FOR A 9-HOUR FIXATION. PATH PRXCEDURES PROCEDURES: 88307/4, IMMUNOPEROXIDAS/2, ABX X6/2, BBX X6, C BLK/1O, D BLK/8 INAL DIAGNOSIS PARTS A AND B RIGHT AXILLA, SENTINEL LYMPH NODE BIOPSIES 1 AND 2: A DERMATOPATHIC LYMPHADENITIS. NO EVIDENCE OF METASTATIC TUMOR ON H&E STEP SECTIONS OR CYTOKERATIN STAINS IN 4 LYMPH NODES EXAMINED. PART C RIGHT BREAST, PARTIAL MASTECTOMY: 1Dc 3|3/3 1. IN SITU AND INFILTRATING DUCT CARCINCMA. THE INVASIVE COMPONENT ISS POORLY DIFFERENTIATED HAVING APOCRINE DIFFERENTIATION, SHONING NUCLEAR ayjocrine diff GRADE 3/3, HIGH MITOTIC INDEX AND TUBULE FORMATION 3 WITH TOTAL NOTTINGHAM SCORE OF 9. HIGH GRADE DCIS OF THE SOLID TYPE WHICH EXTENDS 3 INTO TERMINAL LOBULES SHOWS APOCRINE DIFFERENTIATION, MODERATE MITOTIC 30% Dc1Sg, 3 INDEX, RARE FOCI OF LUMINAL NECROSIS AND COMPRISES APPROXIMATELY 30 sohd PERCENT OF THE TUMOR. apor dFF t,b co. 2.  THE TUMOR HAS A MAXIMUM GROSS DIMENSION OF 2.7 CM.
+
+--- Page 3 ---
+Phone Fax Patient: (Continued) Specimen: Received: Status: Req#: Spec Type: SURGICAL P Subm Dr: FINAL DIAGNOSIS (Continued) 3. THE IN SITU AND INVASIVE COMPONENTS ARE LOCATED 7 MM OR MORE FROM THE INKED MARGINS OF RESECTION. 4. LYMPHOVASCULAR INVASION IS NOT IDENTIFIED. 5. THE BIOPSY SITE IS PRESENT. 6. PROLIFERATIVE FIBROCYSTIC CHANGES INCLUDING SCLEROSING ADENOSIS WITH Fcc CALCIFICATIONS, FLORID USUAL DUCT HYPERPLASIA, MICROCYST FORMATION, 6 A APOCRINE METAPLASIA AND DENSE FIBROUS STROMA. Ca# 1Dh-3 PART D RIGHT BREAST, REEXCISION OF DEEP AND LATERAL MARGINS: FIBROGLANDULAR AND FATTY BREAST TISSUE WITH NO EVIDENCE OF RESIDUAL AM TUMOR AND CLEAR MARGINS. FIBROCYSTIC CHANGES ARE PRESENT. Signed Electronically signed by:_
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diff --git a/output/text/411a7e77-b611-4176-9d61-13caa752f140.txt b/output/text/411a7e77-b611-4176-9d61-13caa752f140.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5047c0cd1a2f76e008a173102063999fa00b72bc
--- /dev/null
+++ b/output/text/411a7e77-b611-4176-9d61-13caa752f140.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+1cs -0 - 3 Carcinoma, iifiltnativg ductcl, Nos 85oof3 UUID:149E102C-FE01-4FC0-8410-CD9743CAFA15 TCGA-C8-A12K-01A-PR Redacted Srte: brest,NOs C50.9 1/c8fnh Pathology Form Specimen Information Collected by: Date: Cime Preserved by: Date: . .Time: +SPECIMENTYPE (#of sample provided)   Frozen Paraffin Block Blood/Serum/Plasma Slide Diseased  Normal Diseased Normal Diseased Normal Diseased Normal x Time to LN2 Time to Formalin Time to LN2 t min min 30 mina EANOOPKP PATHOLOGICALDESCRIPTIONASH A Primary Tumor Organ Size Extension of Tumor Distance to NAT Rsend 14 Sx N0 cm cm X Lymph Nodes Location # Examined # Metastasized Axil 7 1 Distant Metastasis Organ Detailed Location Size. NO Pathological Staging Stage: M D pT g N4. Notes: 4
+
+--- Page 2 ---
+Microscopic Description ..wHistologicalPattern.w Cell Distribution + Structural Pattern  Diffuse  Streaming  Mosaic  Storiform Necrosis Fibrosis Lymphocytic Infiltration  Palisading Vascular Invasion  Cystic Degeneration  Bleeding Clusterized  Alveolar Formation  Myxoid Change  Indian File  Psammoma/Calcification Cellular Differentiation t. Squamous + Adenomatous + Sarcomatous + Lymphomatous.  Squamoid Cell Glandular cell  Round Cell  Large Cell Fibroblast Spindle Cell Cell Stratification Small Cell Secretion Osteoblast  RS Cell/RS Like  Keratin Intracyt. Vacuole Lipoblast Inflam. Cell Desmosome  Gland formation Myoblast Plasma Cell Pearl Well Moderate Poor Ceilular Differentiation: 0 1 II 1II Nuclear Atypia: Aniso Nucleosis Hyperchromatism Nucleolar Prominent  Multinucleated Giant Cell + Mitotic Activity Nuclear Grade: + w.wwewHData. Value Date Marker Result ER  Negative  Positive PR  Negative  Positive  Negative  Positive Her-2/neu  Negative   Positive B-Cell Marker T-Cell Marker Negative Positive Other:  Negative   Positive  Negative  Positive Other: Final Pathology Report Duchl Caneiama 1/F axillwry nrke ly Invanne 1 Histological Diagnosis: Grade: netutaei Comments: Date Pathologist Principal Investigator
+
+--- Page 3 ---
+CONsOLIdateD DIagnOstIC pAthoLOgy foRm* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION Diffuse STRUCTURAL PATTERN X Streaming Mosaic X  Storiform Necrosis Lymphocytic Infiltration  Fibrosis Vascular Invasion  Palisading Cystic Degeneration Clusterized Alveolar Formation Bleeding Myxoid Change Indian File  Psammoma/Calcification 2. Cellular features: Squamous +-Adenomatous Sarcomatous + Lymphomatous Squamoid Cell Glandular cell Round Cell Large Cell Spindie Cell Cell Stratification  Fibroblast Small Cel! Keratin Secretion x Osteoblast  RS CeIl/RS Like Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell Pear!  Gland formation Myoblast Plasma Cell Otherwise Specified: D1 80 Dr Dr7Ne eqos-s 7o 2.Cellular Differentiation: Well Moderately oor Nuclear Atypia: Nuclear Appearance Aniso Nucieosis Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity Nuckar Grade NOs Histological Diagnosis_Inttoahy hetrl (am q.V 3 U1  Careinsms: oltstasses to LiN: Comments: Date Director, Research Pathology PATHOLOGIST STAFF FOR RESEARCH USE ONLY). (INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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diff --git a/output/text/412a4169-63ef-4ae3-a520-f7eccca163f6.txt b/output/text/412a4169-63ef-4ae3-a520-f7eccca163f6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4666c636f568783007ccbd80caebb4e828917b4e
--- /dev/null
+++ b/output/text/412a4169-63ef-4ae3-a520-f7eccca163f6.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Page 1 of 2 Patientt UUID:EE769039-220E-4158-8999-09F17AFB4C46 TCGA-B6-A2IU-01A-PR Redacted m Surg Path CLINICAL HISTORY: Not provided.. GROSS EXAMINATION: A. "Right breast and axillary contents, received fresh. A 1,330 grams, 33.0 x 16.0 x 6.8 cm. The specimen is breast with attached fibrofatty tissue. The breast itself measures 27.5 x 16.0 x 6.8, the axillary tail measures 10.5 x 9.0 x 3.5 cm. The attached ellipse of skin measures 24 x 12.2 cm, with a 4.0 cm areola and a 1.4 cm nipple. The surgical margin of the specimen are inked and the specimen is sliced serially. There is a 5.0 x 5.0 x 2.8 cm firm, ill defined mass in the central region of the breast. It is 2.2 cm from the closest (posterior) margin. BLOCK SUMMARY: Al- cross sections from the nipple. 1cs-0-3 A2- hard mass with closest surgical margin. A3-A6- representative sections of the mass. Chucinma npiltrathay A7- representative sections from the upper outer quadrant. A8- representative sections from the lower outer quadrant. 1obnli Nos A9- representative sections from the lower inner quadrant.. 8520/3 A10- representative sections from the upper inner quadrant. All- seven lymph node candidates from the proximal axillary fat. Site: bust, nos c5v.9 A12- seven lymph node candidates from the middle axillary fat.. A13- six lymph node candidates from the middle axillary fat. h 7fayfn Al4- four lymph node candidates from the distal axillary fat. A15- one lymph node candidate from the distal axillary fat, bisected. A16- four lymph node candidates from the distal axillary fat. A17- one lymph node candidate from the distal axillary fat. A18- five lymph node candidates from the distal axillary fat. DIAGNOSIS: "RIGHT BREAST AND AXILLARY CONTENTS" (MODIFIED RADICAL MASTECTOMY) : A. INFILTRATING CARCINOMA PRESENT, HISTOLOGIC TYPE LOBULAR. N.S.A.B.P. NUCLEAR GRADE 2 OF 3. N.S.A.B.P. HISTOLOGIC GRADE: NOT APPLICABLE. GROSS TUMOR SIZE: 5.0 X 5.0 X 2.8 CM. SIZE OF INVASIVE COMPONENT 5.0 X 5.0 X 2.8 CM. LOCATION OF THE TUMOR, CENTRAL. LYMPHATIC/VASCULAR INVASION ABSENT. MULTIFOCAL TUMOR PRESENT, EXTENSIVE, SEE COMMENT. IN SITU CARCINOMA ABSENT. NIPPLE STATUS, FREE OF TUMOR. SKIN STATUS, FREE OF TUMOR. MUSCLE STATUS, NOT SAMPLED. STATUS OF NON-NEOPLASTIC BREAST TISSUE: BENIGN FIBROCYSTIC CHANGES. SURGICAL MARGIN STATUS: NEGATIVE. LYMPH NODE STATUS: TWENTY-EIGHT AXILLARY LYMPH NODES, NO EVIDENCE OF MALIGNANCY (0/28). ESTROGEN/PROGESTERONE RECEPTOR AND CELL CYCLE ANALYSIS PENDING. METHODOLOGY: IMMUNOHISTOCHEMISTRY, PARAFFIN BLOCK A3. RESULTS WILL BE ISSUED IN AN ADDENDUM.
+
+--- Page 2 ---
+Page 2 of 2 commENr: There is very extensive multifocal/multicentric disease, with random sections distant from the main tumor mass showing foci of infiltrating lobular carcinoma involving all four quadrants of the breast. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es). ADDENDUM 1: Tissue was sent to the for assay of the estrogen and progesterone receptors. The estrogen receptor activity was judged to be positive with an estimated FMoL value of 30. The progesterone receptor activity was judged as positive with an estimated FmoL of value of 101. Please refer to. for a complete report. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es). https://
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diff --git a/output/text/413d80f7-42ba-4485-90cf-b032f4bb0c80.txt b/output/text/413d80f7-42ba-4485-90cf-b032f4bb0c80.txt
new file mode 100644
index 0000000000000000000000000000000000000000..90b6f1bb55d8973465c30a39d4c8b60f87c5f8a2
--- /dev/null
+++ b/output/text/413d80f7-42ba-4485-90cf-b032f4bb0c80.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1cs-0-3 UUID:81A39E94-059E-4307-A7SA-E8C051E9D0C3 carci`omu,mifiYfrstg cluct, nos 85r0/3 TCGA-AR-A0TU-01A-PR Redacted S,te: brst Nos c5o.9 Breast, right, simple mastectomy: Infiltrating ductal carcinoma, Nottingham grade III (of III), forming a well circumscribed mass (4.2 x 4.0 x 3.0 cm) (AJCC pT2) in the lower outer quadrant. Extensive tumor necrosis is present. There is no associated in situ component. The nipple is uninvolved. The surgical resection margins are negative for tumor. The closest margin (deep) is free by 0.3 cm. The surrounding breast tissue shows non-proliferative fibrocystic changes. Lymph nodes, right axillary sentinel Nos. 1A, 1B, 1C, and 2, excision: Multiple (4) right axillary sentinel lymph nodes are negative for tumor. Blue dye is identified in lymph nodes Nos. 1A and 1B. No blue dye is present in lymph nodes 1C or 2 [AJCC pN0(sn)]. Immunohistochemical cytokeratin stain was performed on the paraffin embedded sentinel lymph node tissue and confirms the H&E impression. HER2/neu protein overexpression is negative, score of 1+, according to the interpretation guidelines in the FDA-approved HercepTest. Estrogen: Negative, 0% nuclear staining. Progesterone: Negative, 0% nuclear staining. ER (Estrogen Receptor) test was developed and its performance characteristics determined by  It has not been cleared or approved by the U.S. Food. and Drug Administration.
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diff --git a/output/text/4150a171-16a6-4df2-8cb2-32164284fff4.txt b/output/text/4150a171-16a6-4df2-8cb2-32164284fff4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3eb5d627b9816ed0e9d9bdbedafecf64aa07ad10
--- /dev/null
+++ b/output/text/4150a171-16a6-4df2-8cb2-32164284fff4.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis: Right hemicolectomy preparation with an ulcerated colon carcinoma of the histological type of a moderately differentiated, partially mucus-producing, colorectal adenocarcinoma, almost completely enveloping the blind intestine, measuring 4cm in diameter at the widest point. Invasive spreading of tumor to the outer edges of the muscularis propria. Colon. mucous membrane with a small tubular adenoma with moderate epithelial dysplasia. (synonymously: mild intraepithelial neoplasia). Appendix with mild fibrosis of the wall. Tumor-free oral and aboral resection border as well as greater omentum. Twenty five mesocolic and mesenteric lymph nodes tumor-free with uncharacteristically reactive changes. Tumor stage therefore pT2 pN0 (0/25) L0 V0; G2 R0.
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diff --git a/output/text/4163609c-6101-4cfb-931d-e9840280a385.txt b/output/text/4163609c-6101-4cfb-931d-e9840280a385.txt
new file mode 100644
index 0000000000000000000000000000000000000000..33548653f8f584904d7aa065c272f0b3a060b861
--- /dev/null
+++ b/output/text/4163609c-6101-4cfb-931d-e9840280a385.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID: 5AF066BB-6B09-4B8C-8A09-102AFA1F46FE Department of Pathology.. TCGA-P4-AAVO-01A-PR Redacted Tissue Source Site (Tss) #: Patholgy Accession No: Patient ID: Normal Sample ID: IcD-O3 Pathology Report DIAGNOSIS 8QO|3 (A) RIGHT COLON: C44.9 Colon with tubular adenomas (x3, ranging from 0.3 cm to 2.2 cm) and sessile serrated adenoma (1.4 cm). Qs5/4lJ4y No high-grade dysplasia or invasive carcinoma in colon.. Unremarkable non-neoplastic colonic mucosa. Vermiform appendix with small hyperplastic polyp. Terminal ileum, no tumor present. Fourteen lymph nodes, no tumor present (0/14). (B) RIGHT KIDNEY, PARA CAVAL LYMPH NODES: PAPILLARY RENAL CELL CARCINOMA (4.5 X 4.0 X 3.5 CM), TYPE 2, FUHRMAN NUCLEAR GRADE 3, CONFINED TO THE KIDNEY. (SEE COMMENT) Margins of resection free of tumor. COMMENT The renal cell carcinoma is composed of papillae and nests lined by cells with abundant eosinophilic cytoplasm. Immunohistochemical stains for P504S and vimentin are strongly positive in the tumor cells. CD10 is positive with a membranous staining pattern. Cytokeratin 7 is positive in rare cells. The morphologic features and immunohistochemical profile are consistent with a type 2 papillary renal cell carcinoma. The right colon specimen has been reviewed by The above diagnosis is. based on her interpretation. GROSS DESCRIPTION (A) RIGHT COLON - A right hemicolectomy specimen consisting of segment of large bowel (30.0 cm in length and 10 cm. circumference), attached segment of small bowel (6.0 cm in length and 4.0 cm circumference), and appendix (4.5 x 0.6 x 0.6 cm). There are five polypoid lesions identified. The largest (2.2 x 1.5 x 0.7 cm) is a sessile colonic polyp located 13.0 cm from the distal margin and 17.0 cm from the ileocecal valve. The polyp is superficial..  There is a second polyp (1.4 x 0.8 x 0.3 cm) in the colon located 5.0 cm from the ileocecal valve and 12.0 cm proximal to the 2.2 cm polyp. The polyp is also superficial. There is a third colonic polyp (0.4 cm in greatest dimension) located 4.0 cm from the distal margin and 8.0 cm distal to the. 2.2 cm polyp. The cecum shows two small polypoid lesions. The first (0.6 cm in greatest dimension) is superficial and is 6.0 cm from the ileocecal valve. The second (0.3 cm in greatest dimension) is also superficial and 3.0 cm from the ileocecal valve. No invasive tumor is identified. The surrounding colonic mucosa is unremarkable. The small bowel mucosa and. appendix are both unremarkable. Multiple possible lymph nodes are identified in the surrounding adipose tissue.. SECTION CODE: A1, representative appendix; A2, proximal and distal margins; A3, normal small and large bowel mucosa; A4, 0.6 cm cecal polyp; A5, 0.3 cm cecal polyp; A6, 0.4 cm colonic polyp; A7, A8, 1.4 cm colonic polyp; A9-A14, 2.2 cm colonic polyp; A15, six possible lymph nodes; A16, six possible nodes; A17, six possible nodes; A18, four possible nodes; A19, one possible node, serially sectioned (possibly vessel).. (B) RIGHT KIDNEY, PARA CAVAL LYMPH NODES - A radical nephrectomy specimen (15.0 x 11.0 x 4.0 cm), including a kidney (12.0 x 6.0 x 3.5 cm), segment of renal artery (1.0 x 0.4 cm), renal vein (1.0 cm x 0.7 cm) and ureter (10.0 cm in length x 0.4 cm in average diameter). There is no adrenal identified. There is no lymph node identified. There is well-circumscribed firm tumor (4.5 x 4.0 x 3.5 cm) in the lower pole of the kidney. The tumor is gray-tan with small area of hemorrhage (less than 5%). There is no necrosis identified in the tumor. The tumor is confined to the kidney. The tumor does not invade into perinephric adipose tissue and does not extend to Gerota's fascia. The tumor is pushing the renal sinus adipose tissue but does not invade into the renal sinus adipose tissue.. The adjacent kidney parenchyma is unremarkable. Pelvicalyceal system is smooth and devoid of any lesion. Lymph nodes are not identified..
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+Department of Pathology. Tissue Source Site (TSS) # Patholgy Accession No: Patient ID: Normal Sample ID: Tumor Sample ID: INK CODE: Blue - soft tissue margin. SECTiON CODE: B1, ureter, renal artery, renal vein margin; B2, B3, tumor with perinephric adipose tissue and soft tissue margin; B4, tumor with sinus adipose tissue; B5, B6, tumor with adjacent kidney; B7, tumor, representative section; B8, tumor with area of hemorrhage; B9, normal kidney, representative section. CLINICAL HISTORY Renal cell carcinoma, right; polyp, colon. SNOMED CODES T-71000, T-59300, T-59200, M-83123, M-Y7343, M-82110, M-72042 DISQUAF4
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diff --git a/output/text/417bcab1-39ea-48f5-8911-e202a8a84d0e.txt b/output/text/417bcab1-39ea-48f5-8911-e202a8a84d0e.txt
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+Operative Procedure: Right neck dissection, right superficial parotidectomy, right mandible composite. resection, partial glossectomy, right tonsillectomy and possible left neck dissection. Specimen Received: A: Right level 1B and level 1A B:  Right perifacial lymph node C: Right mandible composite resection (margins to be taken from patient) single stitch right basilar tongue, double stitch right anterior buccal D: Right buccal fat pad E: Right sublingual gland F: Dorsal tongue margin G: Right floor of mouth margin H:  Anterior gingival margin I: Anterior buccal margin J: Soft palate margin K: Superior lip L: Deep tongue margin M: Maxillary alveolar ridge N: Glosso tonsilar sulcus O:  Right deep buccal margin P:  Right temporalis margin Q: Medial pterygoid margin R: Right parotid mass S: Maxillary bone T:  Right neck dissection, single stitch level 2 Final Pathologic Diagnosis: Synoptic Report Right mandibular composite resection: Papillary keratinizing squamous cell carcinoma, moderately differentiated. Histologic type/grade: Papillary keratinizing squamous cell carcinoma, moderately differentiated Tumor size: 8 cm (greatest dimension) Depth of invasion: 0.7 cm (greatest dimension) Lymph-vascular invasion: Not identified. Perineural invasion: Not identified Tumor site: Buccal mucosa to tongue Tumor focality: Single focus Margins: Margins uninvolved by invasive carcinoma Distance from closest margin: 0.4 cm
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+Specify margin(s), per orientation:.  Base of tongue area Margins uninvolved by carcinoma in situ Distance from closest margin: 0.4 cm Specify margin(s), per orientation:.  Posterior buccal mucosa retromolarregion Lymph nodes, extranodal extension: I Right level I-IV, no evidence of malignancy (0 of 21 lymph nodes positive) Pathologic Staging (pTNM): TNM descriptors: Primary tumor (pT): pT4 Regional lymph nodes (pN): pN0 Number examined: 21 Number involved: 0 Distant metastasis (pM): pMO (clinical assessment) Additional pathologic findings: Tumor erodes mandibular cortex but does not invade medullary component Specimen: Buccal mucosa retromolar, lateral tongue and mandible Received: In formalin Procedure: Composite resection, partial mandibulectomy with buccal mucosa resection, right neck dissection Specimen size: 9 x 4.5 x 2 cm Specimen laterality: Right A. Right level IB and IA, lymph node dissection: No evidence of malignancy (0 of 3 lymph nodes positive). Submandibular gland exhibiting no pathologic change. B. Right perifacial lymph node, biopsy: No evidence of malignancy (0 of 2 lymph nodes positive). C. Right mandible, composite resection: Papillary keratinizing squamous cell carcinoma, moderately differentiated (see Synoptic Report for details). D. Right buccal fat pad No evidence of malignancy, frozen section diagnosis confirmed E. Right sublingual gland No evidence of malignancy, frozen section diagnosis confirmed. F. Dorsal tongue margin No evidence of malignancy, frozen section diagnosis confirmed.
+
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+G. Right floor of mouth margin. Mild epithelial dysplasia, no evidence of high grade dysplasia, carcinoma in situ or invasion, frozen section diagnosis confirmed. H. Anterior gingival margin Mild epithelial dysplasia, no evidence of high grade dysplasia, carcinoma. in situ or invasion, frozen section diagnosis confirmed.. I. Anterior buccal margin Mild epithelial dysplasia, no evidence of high grade dysplasia, carcinoma. in situ or invasion, frozen section diagnosis confirmed.. J. Soft palate margin No evidence of malignancy, frozen section diagnosis confirmed.. K. Superior lip No evidence of malignancy, frozen section diagnosis confirmed.. L. Deep tongue margin No evidence of malignancy, frozen section diagnosis confirmed.. M. Maxillary alveolar ridge, biopsy. No evidence of malignancy (scant epithelium present on frozen and permanent sections, frozen section diagnosis confirmed). N. Glossal tonsillar sulcus No evidence of malignancy, frozen section diagnosis confirmed. O. Right deep buccal margin No evidence of malignancy, frozen section diagnosis confirmed.. P. Right temporalis margin No evidence of malignancy, frozen section diagnosis confirmed. Q. Medial pterygoid margin No evidence of malignancy, frozen section diagnosis confirmed.. R. Right parotid mass, excision. Dermal cylindroma, surgical margins free of neoplasia, frozen section diagnosis confirmed. S. Maxillary bone, biopsy: No evidence of malignancy. T. Right neck dissection, levels II-IV:. No evidence of malignancy (0 of 16 lymph nodes positive).. The examination of this case material and the preparation of this report were performed by the staff pathologist..
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+Intraoperative Consult Diagnosis: FSD: Right buccal fat pad: Negative for malignancy. FSE: Right sublingual gland: Negative for malignancy. FSF: Dorsal tongue margin: Negative for malignancy. FSG: Right floor of mouth margin: Negative for malignancy. FSH: Anterior gingival margin: Negative for malignancy. FSI: Anterior buccal margin: Negative for malignancy.. FSJ: Soft palate margin: Negative for malignancy. FSK:  Superior lip: Negative for malignancy. FSL: Deep tongue margin: Negative for malignancy. FSM: Maxillary alveolar ridge: Negative for malignancy. FSN: Glossal tonsillar sulcus: Negative for malignancy. FSO: Right deep buccal margin: Negative for malignancy. FSP: Right temporalis margin: Negative for malignancy. FSQ: Medial pterygoid margin: Negative for malignancy. FSR: Right parotid mass: Eccrine dermal cylindroma. Gross Description: Received are twenty specimen containers all labeled with the patient's name Parts D through part R are all received fresh for frozen section evaluation with parts A through C, S and T received in formalin. Part A is received additionally labeled "right level 1B and level 1A" and consists of a single portion of pink-tan to yellow soft tissue consisting of an apparent salivary gland, which is 4 x 3.2 x 1.3 cm with an additional attached fibrofatty tissue, which are 3 x 2 x 1.1 cm. Step sectioning the salivary gland component reveals the usual tan lobulated architecture without distinct mass. There are no intraparenchymal lymph nodes grossly identified. Representative section of the salivary gland is submitted in cassette A1. Within the associated fibrofatty tissues there are four probable lymph nodes, which range from 0.2 to 1.3 cm in greatest dimension, none of which appear involved by
+
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+tumor, which are submitted as follows: A2  one whole probable lymph node; A3  three whole probable lymph nodes. Part B is received additionally labeled "rightperifacial lymph node" and consists of a single portion of pink-tan nodular and yellow lobulated soft tissue, all of which have aggregate dimensions of 2 x 1.4 x 0.8 cm. Examination of these tissues confirms the presence of two probable lymph nodes, 0.3 and 1.8 cm in greatest dimension, neither of which appear to have tumor involvement. These lymph node candidates are submitted as follows: B1  one whole probable lymph node; B2  one whole probable lymph node bisected. Part C is received additionally labeled "right mandible composite resection (margins taken from patient), single stitch margin right basilar tongue, double stitch right anterior buccal." This composite specimen has aggregate dimensions of 9 x 6 x 5 cm and consists of a partial resection of mandible, having dimensions of 6 x 4.5 x 0.9 cm with associated adherent soft tissue, surfaced by mucosa to include right buccal wall region of trigone, floor of mouth and approaching base of tongue. This soft tissue component has dimensions of 9 x 4.5 by up to 2 cm (base of tongue). The cut surfaces of the soft tissue component are inked in the following manner: Base of tongue black (region of single suture), perimandibular tissues and region approaching trigone pharyngeal wall blue. The mucosa of the specimen is remarkable for an area of probable leukoplakia 3.5 x 2 cm with areas that are slightly raised up to 0.2 cm, superior/pharyngeal trigone region with an abutting separate nodular mass, which is 1.4 x 1.1 x 0.6 cm, grossly consistent with possible fibroma. Subjacent to the area of fibroma and leukoplakia, there is a separate confluent area of presumed invasive tumor, 5.5 x 3.2 cm, which extends from the angle of the mandible/right buccal wall (area of double tailed suture) confluent to the base of tongue region (see gross photo). The area of leukoplakia approaches the posterior cut surface to within 0.4 cm, probable invasive mass approaches anterior cut surface of soft tissue/mandible to within 0.5 cm and posteriorly 0.6 cm, as well as base of tongue to within 0.4 cm. The soft tissues are removed from the bony mandible component and there is gross evidence of tumor adherent to the surface of the bone at the angle of the mandible and subsequent sectioning through this area of adherent tumor reveals superficial involvement of cortical bone with no gross evidence of deep invasion, to be confirmed microscopically (cassettes C4 and C5). Sectioning through the region previously described as probable leukoplakia, confirms superficial involvement of the mucosa and sectioning through the abutting adjacent possible fibroma confirms its tan-white homogeneous cut surface without hemorrhage or necrosis. Sectioning through the primary mass reveals verrucoid change, as well as grossly invasive tumor to a depth of 0.7 cm, which correlates with the region previously abutting the mandible (see cassettes C9-11). Step sectioning through the confluent tumor, which approaches base of tongue, reveals invasion to a depth of 0.4 cm and
+
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+approaches to within 0.7 cm of the deep cut surface base of tongue (see cassette. C12 and C13). Sections are submitted as follows:. C1  anterior mandible margin of surgical resection following decalcification; C2  posterior mandible bony margin of resection following decalcification; C3  superior pole mandible following decalcification; C4-5  sections of mandible with adherent tumor following decalcification; C6 area of leukoplakia;. C7 area of leukoplakia with abutting probable fibroma; C8-10  primary mass to include angle of mandible; C11  tumor approaching angle of mandible and base of tongue region; C12-13  tumor to greatest depth of invasion, base of tongue region. Part D is received additionally labeled "right buccal fat pad (FSD)" and consists of a single portion of yellow lobulated fibrofatty tissue, 2.5 x 2.5 x 0.3 cm, which is submitted for frozen section evaluation (FsD) with residual. frozen section tissue submitted in cassette D. Part E is received additionally labeled "right sublingual gland (FSE)" and consists of a 3 x 2.5 x 0.3 cm portion of pink-tan to yellow soft tissue, which is submitted for frozen section evaluation (FSE) with residual frozen section tissue submitted in cassette E.. Part F is received additionally labeled "dorsal tongue margin (FSF)" and consists of a partially fragmented portion of pink-tan soft tissue, having aggregate dimensions of 1.8 x 1 x 0.3 cm. These tissues are submitted for frozen section evaluation (FSF) with residual frozen section tissue submitted in. cassette F. Part G is received additionally labeled "right floor of mouth margin (FSG)" and. consists of a portion of pink-tan soft tissue, which is 1.5 x 1 x 0.3 cm, which is submitted for frozen section evaluation (FsG) with residual frozen section tissue submitted in cassette G.. Part H is received additionally labeled "anterior gingival margin (FSH)" and consists of multiple fragments of tan-white irregular soft tissues, having aggregate dimensions of 0.6 x 0.5 x 0.2 cm. These tissues are submitted for frozen section evaluation (FSH) with residual frozen section tissue submitted in cassette H. Part I is received additionally labeled "anterior buccal margin (FSl)" and consists of a partially fragmented portion of pink-tan soft tissue, which is 1.7 x 0.5 x 0.3 cm, which is submitted for frozen section evaluation (FSl) with. residual frozen section tissue submitted in cassette I.
+
+--- Page 7 ---
+Part J is received additionally labeled "soft palate margin (FSJ)" and consists of a partially fragmented portion of tan-yellow soft tissue, which is 1.2 x 0.6 x 0.3 cm, which is submitted for frozen section evaluation (FSJ) with residual frozen section tissue submitted in cassette J. Part K is received additionally labeled "superior lip (FSK)" and consists of a single portion of pink-tan irregular soft tissue, which is 1.6 x 0.7 x 0.3 cm, submitted for frozen section evaluation (FSK) with residual frozen section tissue submitted in cassette K.. Part L is received additionally labeled "deep tongue margin (FSL)" and consists of multiple fragments of red-brown soft tissue, having aggregate dimensions of 1.4 x 1 x 0.3 cm. These tissues are submitted for frozen section evaluation (FSL) with residual frozen section tissue submitted in cassette L. Part M is received additionally labeled "maxillary alveolar ridge (FSM)" and consists of two portions of tan-white apparent strips of mucosa, not otherwise designated, having lengths of 1.5 and 2.5 cm with additional dimensions that average 0.2 x 0.2 cm. These tissues are submitted for frozen section evaluation (FSM) with residual frozen section tissue submitted in cassette M. Part N is received additionally labeled "glossal tonsillar sulcus (FSN)" and consists of two portions of pink-tan irregular soft tissues, not otherwise designated, having greatest dimensions of 0.6 and 0.8 cm, submitted for frozen section evaluation (FSN) with residual frozen section tissue submitted in cassette N. Part O is received additionally labeled "right deep buccal margin (FsO)" and consists of a portion of yellow lobulated fibrofatty tissue, which is 1.4 x 1 x 0.3 cm, submitted for frozen section evaluation (FsO) with residual frozen section tissue submitted in cassette O.. Part P is received additionally labeled "right temporalis margin (FSP)" and consists of a single portion of red-brown soft tissue, which is 1.5 x 0.8 x 0.3 cm, submitted for frozen section evaluation (FsP) with residual frozen section tissue submitted in cassette P.. Part Q is received additionally labeled "medial pterygoid margin (FSQ)" and consists of a partially fragmented portion of red-brown soft tissue, which is 2 x 1.3 x 0.3 cm, submitted for frozen section evaluation (FSQ) with residual frozen section tissue submitted in cassette Q. Part R is received additionally labeled "right parotid mass (FSR+X)" and consists of an ovoid portion of pink-tan soft tissue, 2.4 x 1.4 x 1 cm, having no orientation offered or possible. This tissue is inked and representative section is submitted for frozen section evaluation (FSR) with residual frozen section tissue submitted in cassette R1. The remaining tissue is submitted in cassettes R2 and R3. The specimen has been submitted in its entirety.
+
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+Part S is received additionally labeled "maxillary bone" and consists of apparent multiple fragments of bone admixed with soft tissues, all of which have aggregate dimensions of 1.5 x 1.2 x 0.3 cm. These tissues are submitted in toto in cassette S following decalcification.. Part T is received additionally labeled "right neck dissection, single stitch level 2" and consists of the product of a modified right neck dissection, having dimensions of 6 x 2.8 x 1.5 cm, having a suture at one pole indicating a level II location. Within the level II there are three probable lymph nodes, which range from 0.8 to 2.2 cm in greatest dimension. There is no gross evidence of tumor involvement within these lymph nodes.. The lymph node candidates are submitted as follows: T1  largest lymph node bisected; T2  two whole probable lymph nodes. Within level Ill there are two whole probable lymph nodes, having greatest dimensions of 0.6 and 1 cm. These lymph node candidates are submitted in cassette T3 with remaining soft tissues from level Ill submitted in cassette T4 for possible microscopic detection of additional lymph nodes. Within level IV there are five whole probable lymph nodes, which range from 0.2 to 1 cm in greatest dimension, submitted as follows: T5  two whole probable lymph nodes;. T6  three whole probable lymph nodes;. I7  remaining soft tissues from level IV for additional microscopic examination and possible detection of additional lymph nodes. Within level V there are two whole probable lymph nodes, 0.3 cm each in greatest dimension, which are submitted in cassette T8 and remaining soft tissues from level V are submitted in cassette T9 for possible detection of additional lymph nodes. Microscopic Description: Histologic examination reveals a right mandibular composite resection with right neck dissection. The composite resection is prominent for a mucosal squamous cell carcinoma demonstrating a papillary surface configuration with extensive keratinization. Invasion into the underlying connective tissue is seen in the form of sheets and islands. Moderate differentiation is noted in areas. This arises from an extensive zone of carcinoma in situ and dysplasia across the surface of the specimen. The carcinoma focally erodes the cortex of the mandible but does not invade the medullary component. The associated lymph node dissection fails to reveal the presence of metastatic disease. END OF REPORT
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index 0000000000000000000000000000000000000000..92bb29ec75decde3eb19b49da110126d8ddc6074
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+icd-0-3 ltns+iNg duct,NoS Carcnomn, 8500|3 S'rte Coder Srenotnos TSS Pt ID: c50.9 SPECIMENS: UUID:252A2D12-EC16-459E-8486-7814FF39E6C2 TCGA-E2-A105-01A-PR A. RIGHT BREAST NEEDLE LOCALIZATION LUMPECTOMY Redacted B. SENTINEL LYMPH NODE #1 RIGHT AXILLA C. LEFT BREAST LUMPECTOMY NEEDLE LOCALIZATION D. SENTINEL LYMPH NODE #1 LEFT AXILLA SPECIMEN(S): A. RIGHT BREAST NEEDLE LOCALIZATION LUMPECTOMY B. SENTINEL LYMPH NODE #1 RIGHT AXILLA C. LEFT BREAST LUMPECTOMY NEEDLE LOCALIZATION D. SENTINEL LYMPH NODE #1 LEFT AXILLA INTRAOPERATIVE CONSULTATION DIAGNOSIS: A. Right breast, needle localization (Gross Examination only): Tumor O.8cm from nearest anterior margin. By Dr., called to Dr. at. C: Left breast, needle localization (Gross Examination only): Tumor 1.Ocm from nearest anterior margin. By Dr., called to at TPD: Sentinel lymph node #1, left breast (Smears only): Lymph node, negative for tumor.. By Dr., called to Dr. at. GROSSDESCRIPTION: A. RIGHTBREAST NEEDLE LOCALIZATION LUMPECTOMY The specimen, received fresh in a container labeled with patient name and designated as "right breast needle localization right breast lumpectomy" is a segment of breast tissue weighing 72gm and measuring 9.0x8.Ox3.5cm. The specimen is oriented per Dr. as follows: single stitch-anterior, long double stitch-lateral, short double stitch-superior. A metallic wire penetrates through the breast tissue from medial to lateral direction. On serial section, a 1.1x1.1x1.Ocm firm, stellate mass is identified. This mass is 0.8cm from the anterior margin, 1.5cm from lateral margin, 2.0cm from the posterior margin. The exterior surface of the specimen is inked as follows: anterior-blue, inferior-orange, superior-red,. Iateral-yellow, medial-green, posterior-black. Representative sections of the specimen are submitted from cassette A1 to cassette A26. Block summary: A1-A7: the mass and the anterior margin A8-A11: mass and the posterior border (A8 and A9 are 2 consecutive sections connected by the red dot) A12-A17: mass and the lateral margin A18-A17: representative section from the superior border A20-A21: representative section from the inferior border A22-A23: representative section from the medial border A24: representative section from the firm area adjacent to the lateral border A25: representative section from the firm area adjacent to the posterior border. A26: representative section at the area adjacent to the inferior margin B. SENTINEL LYMPH NODE #1 RIGHT AXILLA The specimen, received fresh in a container labeled with patient name and designated as "sentinel lymph node #1 right axilla" consists of 2 firm lymph node measuring 1.0x0.5x0.3cm and 2.0x1.0x0.5cm The lymph node is submitted in toto in cassette B1 and B2. C.LEFTBREAST LUMPECTOMY NEEDLE LOCALIZATION The specimen, received fresh in a container labeled with patient name and designated as "left needle Iocalization lumpectomy" is a segment of breast tissue weighing 75 grams and measuring 8.5 x 5.5 x 3.4 cm. The specimen is oriented as follows: single stitch, anterior; double stitch, lateral; triple stitch superior. The specimen is inked as follows: superior, red; inferior, orange; medial, green; lateral, yellow; anterior, blue; posterior, black. The specimen is serially sectioned and it reveals a firm, white_ stellate mass measuring 3 x.2.5 x.2 cm. Grossly, the tumor is 1 cm from the anterior margin, 1.6 cm from the posterior margin, 2.3 cm from the inferior margin, 2.6 cm from the superior margin, 1.3 cm from the medial margin and 1 cm from the lateral margin. The rest of the section of the specimen are submitted in cassettes C1  C27. Block summary:
+
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+C1-C3: tumor and the anterior margin C4-C8: tumor and the lateral margin C9-C12: tumor and the medial margin C13-c20: posterior margin adjacent to the tumor C21-c23: representative section from the inferior margin C24-C27: representative section from the posterior lateral area of the breast D. SENTINEL LYMPH NODE #1 LEFT AXILLA The specimen, received fresh in a container labeled with patient name and designated as "sentinel lymph node #1 left axilla" consists of a fibroadipose fragment of tissue measuring 6.0x3.0x1.Ocm. Within the tissue, 1 lymph node is identified measuring 1.3x1.2x1.Ocm. Touch prep is prepared. The specimen is submitted in toto in cassette D1-D3. DIAGNOSIS: A. RIGHT BREAST, NEEDLE LOCALIZED EXCISIONAL BIOPSY: - INVASIVE MAMMARY CARCINOMA, TUBULOLOBULAR TYPE, MODIFIED SBR GRADE I - TUMOR IS 1.8 CM IN MAXIMUM DIMENSION MEASURED MICROSCOPICALLY - FINAL SURGICAL MARGINS ARE FREE OF TUMOR - SEE SYNOPTIC TEMPLATE AND COMMENT - DUCTAL CARCINOMA IN SITU, LOW NUCLEAR GRADE, SOLID TYPEE - FINAL SURGICAL MARGINS ARE FREE OF DCIS - DUCTAL HYPERPLASIA (USUAL TYPE), AND COLUMNAR CELL CHANGEE WITH COLUMNAR CELL HYPERPLASIA. - FIBROSIS, FAT NECROSIS AND HEMOSIDERIN CONSISTENT WITH PRIOR br BIOPSY SITE CHANGE. B. SENTINEL LYMPH NODE, #1 RIGHT AXILLA, BIOPSY: - ONE LYMPH NODE NEGATIVE FOR CARCINOMA (0/1)  C. LEFT BREAST, NEEDLE LOCALIZED EXCISIONAL BIOPSY: - INVASIVE DUCTAL CARCINOMA, MODIFIED SBR GRADE II - TUMOR IS 3.0 CM IN MAXIMUM DIMENSION - FINAL SURGICAL MARGINS ARE FREE OF TUMOR - SEE SYNOPTIC TEMPLATE - DUCTAL CARCINOMA IN SITU, INTERMEDIATE NUCLEAR GRADE, SOLID TYPE - SURGICAL MARGINS ARE FREE OF DCIS - FIBROCYSTIC CHANGES WITH DUCTAL HYPERPLASIA (USUAL TYPE) - COLUMNAR CELL CHANGE AND COLUMNAR CELL HYPERPLASIA - BENIGN INTRADUCTAL PAPILLOMA - FIBROSIS SUGGESTIVE OF PRIOR BIOPSY SITE CHANGE D. SENTINEL LYMPH NODE, #1 LEFT AXiLLA, BIOPSY: - ONE LYMPH NODE NEGATIVE FOR CARCINOMA (0/1) COMmENT: The invasive tumor present in the_right breast (specimen) shows a morphology that is predominantly.that of lobular carcinoma. In many areas, however, and particularly on slide A5 the tumor shows small tubular structures with angulated contours and apocrine snouting. This combined  morphology is that of tubulolobular carcinoma. This tumor was e-cadherin positive on the original biopsy, a finding that normally favors ductal carcinoma. Tubulolobular carcinoma, however, has been reported to be e-cadherin positive also. Since the WHO currently includes. tubulolobular carcinoma as a variant of lobular carcinoma, that is how it is listed on the synoptic template since there is no option for tubulolobular carcinoma in that template. SYNOPTIC REPORT - BREAST Specimens Involved Specimens: A: RIGHT BREAST NEEDLE LOCALIZATION LUMPECTOMY Excision Specimen Type: Needle Localization: Yes
+
+--- Page 3 ---
+Laterality: Right. Invasive tumor: Present Multifocality: No WHO CLASSIFICATION  Invasive lobular carcinoma 8520/3 Specimen size: Size of Invasive focus 1.8cm Additional dimensions: 1.1cm x 1cm Tumor Site: Not specified Margins: Negative Distance from closest margin:  0.3cm Margin: anterior Tubular score: 3 (<10% tubule) Nuclear grade: 1 Mitotic score (Olympus 40x): 10-6/10 Modified Scarff Bloom Richardson Grade: I (3-5 points) Necrosis: Absent Vascular/Lymphatic Invasion:  None identified Lobular neoplasia:  None Lymph nodes: Sentinel lymph node only Lymph node status: Negative 0/1 Non-neoplastic areas: Ductal hyperplasia. DCIS present Margins uninvolved by DCIS DCIS Quantity: Estimate % 5 DCIS type: Solid DCIS location: Associated with invasive tumor Nuclear grade: Low Necrosis: Absent Location of CA++: Benign epithelium Pathological staging (pTN): pT 1c N 0 Comment(s): Tubulolobular type carcinoma is not listed as a separate entity in this template. It is considered a variant of lobular carcinoma in the WHO classification system, despite frequently being e-cadherin positive. SYNOPTIC REPORT - BREAST Specimens Involved Specimens: C: LEFT BREAST LUMPECTOMY NEEDLE LOCALIZATION Specimen Type: Excision Needle Localization: Yes Laterality: (Left) Present Invasive tumor: Multifocality: No WHO CLASSIFICATION Invasive ductal.carcinoma, NOs 8500/3 Specimen size: Size of Invasive focus 3cm Additional dimensions: 2.5cm x 2cm Tumor Site: Not specified Margins:  Negative Distance from closest margin:  0.4cm Margin: Lateral, medial and anterior. Tubular score: 3 (<10% tubule) Nuclear grade: 2 Mitotic score (Olympus 40x): 2 (7-13/10 Modified Scarff Bloom Richardson Grade: 11 (6-7 points) Necrosis: Absent Vascular/Lymphatic Invasion:None identified Lobular neoplasia: None Lymph nodes: Sentinel lymph node only Lymph node status: Negative 0/1
+
+--- Page 4 ---
+Non-neoplastic areas: Papilloma, fibrocystic changes with ductal hyperplasia. DCIS present  Margins uninvolved by DCIS DCIS Quantity: Estimate % 10 DCIS type: Solid DCIS location: Associated with invasive tumor Nuclear grade: Intermediate Necrosis:  Present Location of CA++: Benign epithelium Pathological staging (pTN): pT 2 N 0 CLINICAL HISTORY: None given PRE-OPERATIVE DIAGNOSIS: Bilateral breast ca Gross Dictation:, 1 Microscopic/Diagnostic Dictation:., Pathologist, Microscopic/Diagnostic Dictation:., Pathologist,. Final Review:., Pathologist, Final Review: Pathologist, Final: Pathologist,
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diff --git a/output/text/41a3bdf3-4725-4147-a286-fa3449982878.txt b/output/text/41a3bdf3-4725-4147-a286-fa3449982878.txt
new file mode 100644
index 0000000000000000000000000000000000000000..165e28739e218781ed4bf750fc2622a0324f892f
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1cs-0-3 Cavuiomu,infiltnatng ductl, Nos 85o0/3 Pc Sih: Brast ente! C50.1 1/i9/n k pntm CQcF Srh: Drest, Nos c5o.9 Diagnosis: 1. Moderately differentiated invasive ductal carcinoma (tumor diameter: 1.9 cm) with focal intraductal components. Together with the preliminary finding, this gives rise to the following tumor classification: NOS, G ll, pT1cN1aL1V0R0 UUID : D4E86E20-B75E-4CDA-83F2-22C481D4B9E8 Redacted
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diff --git a/output/text/421f0ada-c519-4872-b279-b5e11bd25379.txt b/output/text/421f0ada-c519-4872-b279-b5e11bd25379.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2d4dc9f7d3fa9ce41d5064f4cc0d3d1799d6a741
--- /dev/null
+++ b/output/text/421f0ada-c519-4872-b279-b5e11bd25379.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+UID:B5B00BA7-3720-417A-98E9-DFF9EABC32B6 TCGA-CQ-A4CA-01A-PR Redacted Department of Pathology Patient Name. Copath # MRN: Service: Otolaryngology Collected: DOB: Visit #: Resulted: Gender: Location: HCN: Facility: Ordering MD:. Surgical Pathology Consultation Report. 1c0-u - 3 SPECIMEN(S) RECEIVED c arcnmo,Sguxmeny cill, N05 1. Lymph-Node: left external jugular node 80'7013 2. Soft Tissue: left level 1 3. Soft Tissue: left level 2A Site : Tonge,vint^uL surfyu, N0s 4. Soft Tissue: left level 3 5. Soft Tissue left level 4 C0a.. 6. Neck: left partial glossectomy, 7. Soft Tissue: anterior mucosal margin 8. Oral Cavity: floor of mouth. Oral Cavity: dorsal tongue margin, DIAGNOSIS 1. Left external jugular nodes: - Two lymph nodes and salivary tissue, negative for malignancy (0/2). 2. Left neck; level I:  Four lymph nodes, negative for malignancy (o/4). - Submandibular gland with no pathologic abnormality. Left neck; level IIA: - Nine lymph nodes, negative for malignancy (0/9). 4. Left neck; level III: - Seven lymph nodes, negative for malignancy (o/7). 5. Left neck; level Iv: - Three lymph nodes, negative for malignancy (0/3). 6. Left partial glossectomy: - Squamous cell carcinoma, moderately differentiated. a. Maximum tumour dimension is 2.5 cm.. b. Tumour thickness is 0.6 cm. c. No perineural invasion is identified.
+
+--- Page 2 ---
+d. No lymphovascular invasion is identified.. Status: complete Page: 1 of 5 Patient Name Copath # MRN: Service: Otolaryngology Collected: DOB: Visit #: Resulted: Gender : Location: HCN: Facility: Ordering MD: e. Margins of resection, negative for tumour (> 0.5 cm). The closest margin to tumour is anterior at 0.6 cm. 7. Anterior mucosal margin: - Negative for malignancy. 8. Floor of mouth: - Negative for malignancy. 9. Dorsal tongue margin: - Negative for malignancy. SYNOPTIC DATA Specimen: Ventral surface 'of tongue, not otherwise specified (nos) Floor of mouth, NOS Other: Left neck dissection (levels I-IV) Received: Fresh Procedure: Glossectomy: Left partial glossectomy. Neck (lymph node) dissection: Left neck dissection (levels I-iv). Specimen Size: Greatest dimension: 5.3 cm Additional dimension: 4.3 cm Additional dimension: 0.8 cm Specimen Laterality: Left Tumor Site: Ventral surface of tongue, NOS Floor of mouth, NOS Tumor Focality: Single focus Tumor Size: Greatest dimension: 2.5 cm Additional dimension: 2.4 cm Additional dimension: 0.6 cm
+
+--- Page 3 ---
+Histologic Type: Squamous cell carcinoma, conventional Histologic Grade: G2: Moderately differentiated. Margins: Margins uninvolved by invasive carcinoma Distance from closest margin: 0.6 cm. Status: complete Page: 2 of 5 Patient, Name: Copath # MRN: Service: Otolaryngology Collected: DOB: Visit #: Resulted: Gender: Location: HCN : Facility: Ordering MD: Margin(s): Anterior margin. Margin status for carcinoma in situ is not applicable Lymph-Vascular Invasion: Not identified Perineural Invasion: Not identified Lymph Nodes, Extranodal Extension: Not identified TNM Descriptors: Not applicable Primary Tumor (pT): pT2:Tumor more than 2 cm but not. more than 4 cm in greatest dimension. Regional Lymph Nodes (pN):. pN0: No regional lymph node metastasis Number of regional lymph nodes. examined: 25 Number of regional lymph nodes involved: 0 Distant Metastasis (pM): Not applicable *Pathologic Staging is based on AJcc/uIcc TNm, 7th Edition. ELECTRONICALLY VERIFIED BY: GROSS DESCRIPTION 1 The specimen is labeled with the patient's name and "left external
+
+--- Page 4 ---
+jugular node"..  It consists of portion of fibroadipose tissue measuring 1.5 x 0.9 x 1cm. Multiple lymph nodes ranging from 0.2 to 0.8cm are identified. Representative sections are submitted. 1A 1 node 1B larger node bisected 2. The specimen is labeled with the patient's name and "left level 1". It consists of portion of fibroadipose tissue measuring 6 x 4.5 x 3 cm. Multiple lymph nodes ranging from 0.5 to 1.4 cm are identified. The grossly unremarkable submandibular gland is identified measuring 5 x 3.2 x 2.5 cm. Representative sections are submitted. 2A 2 nodes 2B 1 node Status: complete. Page: 3 of 5 Patient Name. Copath #: MRN: Service: Otolaryngology Collected: DOB: Visit #: Resulted: Gender  Location: HCN : Facility: Ordering MD: 2C 1 node bisected 2D submandibular gland 3. The specimen is labeled with the patient's name and "left level 2A". It consists of portion of fibroadipose tissue measuring 6 x 3 x 1.5 cm. Multiple lymph nodes ranging from 0.2 to 1.1 cm are identified. Representative sections are submitted. 3A multiple nodes 3B 2 nodes 3C 4 nodes 4. The specimen is labeled with the patient's name and "left level 3". It consists of portion of fibroadipose tissue measuring 3.5 x 2.5 x 1 cm. Multiple lymph nodes ranging from 0.1 to 1.3 cm are identified. Representative sections are submitted. 4A-4B multiple nodes 5. The specimen is labeled with the patient's name and "left level 4". It consists of portion of fibroadipose tissue measuring 5 x 1.7 x 1 cm. Multiple lymph nodes ranging from 0.1 to 0.7 cm are identified. Representative sections are submitted. 5A multiple nodes
+
+--- Page 5 ---
+6. The specimen is labeled the patient's name and as "left partial glossectomy". It consists of a portion of left tongue measuring 4.3 sI x 0.8 ML x 5.3 AP cm. There is one anterior suture orientation..  There is an ulcerated tumor involving the ventral surface of the tongue/ floor of mouth. The tumor measures 2.5 SI x 0.6 ML x 2.4 AP cm. The tumor is 0.6 cm from the anterior margin. It is located at 1.0 cm from the lateral margin, 0.7 cm from the deep/medial margin, and 2.0 cm from the posterior margin. Representative sections are submitted. 6A anterior margin frozen section. 6B anterior margin 6C posterior margin 6D deep medial margin and tumor. 6E superior margin 6F lateral margin 6G tumor and deep medial margin. 7. The specimen is labeled with the patient's name and as "anterior mucosal margin". It consists of a fragment of tissue measuring 1.7 x 0.5 Status: complete Page: 4 of 5 Patient Name: Copath #:. MRN : Service: Otolaryngology Collected: DOB: Visit #: Resulted: Gender: Location: HCN : Facility: Ordering MD: x 0.2 cm. The specimen is submitted in toto for frozen section. 7A frozen section control 8. The specimen is labeled with the patient's name and as "floor of mouth".  It consists of a fragment of tissue measuring 1.5 x 0.2 x 0.2 cm.  The specimen is submitted in toto for frozen section. 8A frozen section control 9. The specimen is labeled with the patient's name and as "dorsal tongue margin". It consists of a fragment of tissue measuring 2.2 x 0.4 x 0.2cm. The specimen is submitted in toto for frozen section. 9A frozen section control
+
+--- Page 6 ---
+QUICK SECTION 6. Left partial glossectomy suture anterior:. 6A: sagittal section including closest mucosal margin and deep margin: negative for carcinoma 7. Anterior mucosal margin: 7A: negative for carcinoma: negative for. carcinoma 8. Floor of mouth margin: 8A: negative for carcinoma: negative for carcinoma 9. Dorsal tongue margin: '9A: negative for carcinoma. Case called in to Status: complete Page: 5 of 5
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diff --git a/output/text/42684df2-b608-4026-9d15-b3c91845388c.txt b/output/text/42684df2-b608-4026-9d15-b3c91845388c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..00975c8aabe5a2b99fb255a55838f982b27b8b74
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+++ b/output/text/42684df2-b608-4026-9d15-b3c91845388c.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: FMp/SSN: DOb/Age/Sex: Age: F Race: WHITE Taken: Location: Received: Physician(s) : Reported: **AMENDED** Ics-0 -3 Carcm`omnn, infiltnsttng ouctel, Nos SPECIMEN: 8500/3 C: LEFT BREAST TISSUE D: LEFT BREAST TISSUE LOWER INNER QUADRANT 1/25/1 l UUID:5C563F73-3793-4902-ACB8-82F432AED592 FINAL DIAGNOSIS: TCGA-A2-A0D3-01A-PR Redacted A. BREAST, RIGHT, MASTECTOMY: FOCAL USUAL DUCTAL HYPERPLASIA. FOCAL LACTATIONAL/SECRETORY CHANGE  STROMAL SCLEROSIS AND FOCAL APOCRINE METAPLASIA.  UNREMARKABLE SKIN AND NIPPLE. - NO EVIDENCE OF MALIGNANCY. B. LYMPH NODE, LEFT AXILLA SENTINEL NODE, RESECTION: ONE LYMPH NODE NEGATIVE FOR TUMOR BY LIGHT MICROSCOPY AND CYTOKERATIN IMMUNOHISTOCHEMISTRY. C. BREAST, LEFT, mASTEcToMY: - WELL DIFFERENTIATED (GRADE I/III) INFILTRATING DUCTAL CARCINOMA. * NOTTINGHAM SCORE: 5 OUT OF 9 (TUBULES=2, NUCLEI=2, MITOSES=1). * TUMOR SIZE (GREATEST DIMENSION): 1.9 CM (meaSured grOssly). * MICROCALCIFICATIONS: IDENTIFIED WITHIN INTRADUCTAL COMPONENT AND BENIGN DUCTS. * VENOUS / LYMPHATIC INVASION: NOT IDENTIFIED. * MARGINS: NEGATIVE - DISTANCE FROM NEAREST MARGIN: O.4 CM FROM SUPERFICIAL MARGIN (measured grossly). K INTRADUCTAL COMPONENT: DUCTAL CARCINOMA IN SITU, INTERMEDIATE NUCLEAR GRADE (DCIS, GRADE II); SOLID AND CRIBIFORM TYPES WITH FOCAL INTRALUMINAL NECROSIS AND CALCIFICATIONS. SKIN OR NIPPLE INVOLVEMENT: ABSENT. ESTROGEN RECEPTORS: POSITIVE (please see prior specimen) * PROGESTERONE RECEPTORS: POSITIVE (pleaSe see prior specimen) * HER2 NEU By IHC: NEGATIVE (please see prior specimen (see comment). * PATHOLOGIC STAGE: pT1cNO(i-)Mx. ADDITIONAL PATHOLOGIC CHANGES: * FOCAL USUAL DUCTAL HYPERPLASIA. Page 1 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 2 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: FINAL DIAGNOSIS (continued) : D. BREAST, LEFT LOWER INNER QUADRANT, EXCISION: - BENIGN BREAST TISSUE; NEGATIVE FOR TUMOR. Comment: There is no change in the original pathologic diagnosis. This amendment is issued to reflect a change in the HEr2 immunohistochemical status. The original report stated that the HEr2 was positive. based on the core biopsy material material has been recently amended to reflect that the Her2 is actually However, that core biopsy negative (further supported by confirmatory Fish study showing no amplification).  Report Electronically Signed Out CLINICAL DIAGNOSIS AND HISTORY: -year-old female with left breast cancer, and strong family history, desires prophylactic bilateral mastectomy.. GROSS DESCRIPTION: A. Received in formalin, labeled with the patient's name, designated "RIGHT BREAST TISSUE, LONG = LATERAL, SHORT = SUPERIOR" is a 300 gram right mastectomy specimen oriented with a short stitch superior, and long stitch lateral.* The specimen measures 16.0 x 16.0 x 3.0 cm, and displays an 8.5 x 3.0 cm lightly pigmented skin ellipse on the superficial surface. The centrally located everted nipple measures 1.5 cm and is free of discharge. The deep margin is inked in black. Serial sections reveal markedly dense, pink-white, fibrous tissue involving 7o% of the cut surface. The tissue is slightly nodular, however, no discreet mass or lesion is identified. No lymph nodes are identified. sections are submitted as follows:  Representative Cassette Key:. Al: Skin. A2: Upper outer quadrant. A3: Lower outer quadrant. A4: Lower inner quadrant A5: Upper inner quadrant. A6: Central.. Matched sections of A1 through A6 are submitted in OcT for cBcp protocol. Page 2 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 3 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION (continued) : A7: Nipple. A8: Upper outer quadrant. A9: Lower outer quadrant. A10: Lower inner quadrant. All: Upper inner quadrant. 11C11 B. Received in formalin, labeled with the patient's name, designated "LEFT AXILLA SENTINEL NODE" is a single 1.8 x 1.8 x 0.6 cm pink-tan lymph node. The lymph node is trisected, and entirely submitted in cassettes B1 and B2. Matched section of B1 is submitted in ocr for Cbcp protol. c. Received in formalin, labeled with the patient's name, designated "LEFT BREAST TISSUE, LONG LATERAL, SHORT SUPERIOR" is a 284 gram left mastectomy specimen oriented with a short stitch superior and long stitch lateral. The specimen measures 14.5 cm medial to lateral, 14.0 cm superior to inferior, and 2.5 cm anterior to posterior. The lightly pigmented superficial skin ellipse measures 7.0 x 3.2 cm and displays a centrally located, everted nipple measuring 1.8 x 1.5 x 1.3 cm. The nipple is free of discharge.  The deep margin is inked in black, and. the superficial inferior half is inked in blue. Serial sections reveal a 1.9 x 1.6 x 1.6 cm well defined, pink-tan, gritty, indurated mass in the lower outer quadrant at the junction of the deep and superficial margins. The mass"is located 1.0 cm from the deep margin, and 0.4 cm from the superficial margin. The remainder of the specimen is composed of 70% of markedly dense, diffusely nodular fibrous tissue with scattered gray-blue cysts measuring up to 0.3 cm in greatest dimension. No lymph nodes are identified. Representative sections are submitted: Cassette Summary: C1: Skin. C2: Nipple. c3: Mass, lower outer quadrant.. C4-c6: Deep and superficial margins of c3. c7: Mass with superficial margin. c8: Additional superficial margin. c9: Adjacent normal with cyst (lower outer quadrant). c10: Upper outer quadrant. cll: Upper inner quadrant. c12: Lower inner quadrant. Matched sections of c1-c3, c7, and c9-c12 are submitted in OcT for cBcp protocol. c13-c15: Additional representative sections of breast mass. 15cF: Page 3 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 4 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: GRoss DescrIpTion (continued) : D. Received in formalin, labeled with the patient's name, designated "LEFT BREAST TISSUE LOWER INNER QUADRANT" are multiple fragments of yellow, lobular, adipose tissue. The first fragment measures 5.5 x 3.0 x 0.4 cm. The second fragment measures 5.0 x 2.5 x 0.5 cm. Serial sectioning is remarkable for an area of focal hemorrhage measuring 0.4 x 0.3 x 0.2 cm located 0.2 cm from the nearest inked margin. Representative section is submitted in cassette Dl. Also noted is a fibrotic band measuring 0.4 x 0.4 x 0.2 cm abutting the closest inked margin. Two representative sections are submitted in cassette D2. The second specimen is inked in blue, and is serially sectioned to reveal. unremarkable, yellow, cut surfaces. Representative sections are submitted in cassettes D3-D4. 4CF Page 4 End of Report. FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
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diff --git a/output/text/426d2046-9915-494f-987f-f9acd4957d43.txt b/output/text/426d2046-9915-494f-987f-f9acd4957d43.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6dd9f6ec9508e9b236c8c52a2fc9b23a380befa1
--- /dev/null
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+
+--- Page 1 ---
+Surgical Pathology Report Name: Case #: DOB: Collected: Gender: Received: MRN: Reported: Location: Copy To: Physician: Pathologic Interpretation: A. Sentinel node #1 Count # FS: - Metastatic carcinoma to lymph node (1/1) with extracapsular extension. B. Sentinel node #2 count :s: Jcs-0-3 - No malignancy seen in one lymph node (0/1). - Immunohistochemistry for keratin to follow. Cercioma, mnfiltratng ductl Nos 8500/3 Siti : brast Nos c5o.9 H8/n C. Sentinel node #3 count - No malignancy seen in one lymph node (0/1). - Immunohistochemistry for keratin to follow. D. Sentinel node #4 count FS: - No malignancy seen in one lymph node (0/1). UUID:E8B860F6-F3FD-4FDF-B467-8988646C2F00 TCGA-EW-A131-01A-PR Redacted - Immunohistochemistry for keratin to follow. E. Sentinel node #5 count Fs: - No malignancy seen in one lymph node (0/1). - Immunohistochemistry for keratin to follow. F. Sentinel node #6 count FS: - No malignancy seen in one lymph node (0/1). - Immunohistochemistry for keratin to follow. G. Axillary fat (perm): - No malignancy seen in one lymph node (0/1). H. Skin right breast: - Skin with no specific pathologic change. i. Right breast lumpectomy (short stitch superior, long lateral ) fresh: - Invasive poory differentiated ductal carcinoma, Nottingham grade 3 (3 + 3 + 3), 3.5 cm. - Lymphovascular space invasion is not identified. - Specimen margins are negative for tumor. J. Additional deep margin (perm): - No malignancy seen.. K. Right axillary contents (perm): - No malignancy seen in ten lymph nodes (0/10). L. Left breast tissue (perm): No malignancy seen. Surgical Pathology Tumor Summary. Specimen: partial breast. Procedure: Excision without wire-guided localization Lymph node sampling: Sentinel lymph nodes, axillary dissection (partial or complete dissection) Specimen Integrity: Single intact specimen Specimen Size: Greatest dimension: 9.5 cm Additional dimensions: 8 x 5.5 cm Specimen Laterality: Right. Tumor Size: Greatest dimension of largest focus of invasion over 0.1 cm: 3.5 cm Additional dimensions: 3 x 3 cm Skin: Invasive carcinoma does not invade into the dermis or epidermis Skeletai Muscle: No skeletal muscle present
+
+--- Page 2 ---
+SUrgICAL PatHOL Report Histologic type of invasion: Invasive ductal carcinoma. Glandular (Acinar/tubular Differentiation: Score 3: <10% of tumor are forming glandular/tubular structures  Nuclear Pleomorphism: Score 3: Vesicular nuclei, often with prominent nucleoll exhibiting marked variation in size anq shape, occasionally with very large and bizarre forms. Mitotic Count: Score 3 Overall Grade: Grade 3: scores of 8 or 9 Margins uninvolved by invasive carcinoma Lymph-vascular invasion: Not identifled Number of lymph nodes examined: 6 Total number of lymph nodes examined (sentine! and non-sentinel): 17 Number of lymph nodes with macrometastasis (>0.2 cm): 1 Extranodal extension: Present Method of evaluation of sentinel lymph nodes: Hematoxylin and eosin (H & E ) one level, immunohistochemistry PT2: Tumor >20 mm but <50 mm in greatest dimension PN1a: Metastases in 1 to 3 axillary lymph nodes, at least 1 metastasis greater than 2.0 mm Distant metastasis: not applicable Estrogen Receptor: Performed on another specimen 1. immunoreactive tumor cells present (>1%) Progesterone Receptor: Performed on another specimen . immunoreactive tumor cells present (>1%) Immunoperoxidase studies: Performed on another specimen , negative (score 0) nt requwe FDA spprovai These cones ss use0: 1D5=ER, PoR 636=PR, A485=HER2 H11=EGFR, CCH2/DDG9=CMV, F30.4.1=AR ana HPV by iSH. Ax immunonstochemic stains 2N used with lormain or molecuar #xed, paratin embedted tissue. Detection is by LSA8. The resuits are reed by a pathologist es postive or negative. As the attending pathoiogiet, I attest that i: () Examinedne relevent preparaton(s) for the specinen(s): and (#) Rendered th+ dmgnoss(es). Procedures/Addenda Addendum Date Ordered: Status: Signed Out Date Complete: Date Reported: Addendum Diagnosis B. Immunohistochemistry for Keratin stain is negative for metastatic carcinoma to the lymph node. C. Immunohistochemistry tor Keratin stain is negative for metastatic carcinoma to the lymph node. D. Immunohistochemistry for Keratin stain is negative for metastatic carcinoma to the iymph node. E. Immunohistochemistry for Keratin stain is negative for metastatic carcinoma to the lymph node. Intraoperative Consultation AFS. Sentinel node #1 Count # Fs: One lymph node with metastatic carcinoma BFS. Sentinel node #2 count FS: Page 2 of 4
+
+--- Page 3 ---
+SURGICAL PATHOL Report One lymph node, no carcinoma seen. CFS. Sentinel node #3 count Adipose tissue only. No lymph node identified grossly.. DFS. Seninel node #4 count : FS: One lymph node, no carcinoma seen. EFS. Sentinel node #5 count - FS: One lymph node, no carcinoma seen. FFS. Sentinel node #6 count FS: One lymph node, no carcinoma seen. Ciinical History: Patient is a. female with right breast cancer. Pre Operative Dlagnosis: Right breast cancer. Speclmen(s) Received: A: Sentinel node #1 Count # .FS B: Sentine! node #2 count FS C: Sentinel node #3 count D: Seninel node #4 count : FS E: Sentinel node #5 count FS F: Sentinel node #6 count FS G: Axillary fat (perm) H: Skin right breast I: Right breast lumpectomy (short stitch superior, long lateral ) fresh. J: Additional deep margin (perm) K: Right axillary contents (perm) L: Left breast tissue (perm) Gross Description: Received fresh and labeled "sentinel node #1 count # FS" consists of pale yellow soft tissue measuring 1 x 0.3 x A. 0.2 cm. The cassettes are submitted as follows: Submitted for frozen section 1 2 Remainder of the tissue Received fresh and labeled *sentinel node #2 count. FS" consists of light brown fragments ---49-- count measuring 1 B. x 0.2 x 0.3 cm in aggregate. The cassettes are submitted as follows: 1 Submitted for frozen section 2 Remainder of the tissue. C. Received fresh and labeled *sentinel node #3 count. ' consists of light brown soft tissue measuring 2 x 1|x 1 cm. The. specimen submitted in toto in two cassettes. D. Received fresh and labeled "seninel node #4 count FS" consists of pale white tissue measuring 1 x 0.$ x 0.2 cm. Specimen as follows: Submitted for frozen section. 1 2 Remainder of tissue E. Received fresh and labeled "sentinel node #5 count FS" consists of sift white fragment measuring 1 x 0|3 x 0.2 cm.. The specimen is submitted as follows: 1 Submitted for frozen section Page 3 of 4d
+
+--- Page 4 ---
+Surgical Pathol Report 2 Remainder of tissue. F. Received fresh and labeied "sentinel node #6 count. FS" consists of light brown fragment measuring 0.5 x 0.3 x 0.2. cm. The specimen is submitted as follows: Submitted for frozen section 2 Remalnder of tissue G. Received in formalin and labeled *axillary fat (perm)" consists of yellow brown soft tissue measuring 4 x 2 x 3 cm in aggregate. The entire specimen is submitted in toto in eight cassettes. H. Received in formalin and labeled *skin right breast" consists of skin tag measuring 5 x 0.5 x 0.1 cm. A representative section of the skin tag is submitted in one cassette.. I. Received in formalin and labeled "right breast lumpectomy (short stitch superior, long lateral ) fresh" consists|of breast tissue mass measuring 186 grams and measures 9.5 cm medial to lateral, 5.5 cm inferior superior and 8 cm anterior to posterior. It is round to oval in shape. It is yellow in color and soft in consistency. The specimen has suture$ for orientation. The specimen is inked as foilows: anterior yellow; superior blue; posterior black; inferior green: Iateral orange. and medial red. Serial sectioning of the specimen reveals a well defined round to oval mass measuring 3 x 3 x 3.5 cm. It is hard in consistency. It occupies 20% of the entire specimen. The nearest margin is at the superior margin which is 1.5. cm from the mass. Remaining margins are away from the mass. There is an area of fibrosis which is situated anterior to. the mass; it is 1 cm away from the mass. The area of fibrosis measures 1 x 1 cm. The breast parenchyma i between the mass and the fibrosis is normal. The remaining breast parenchyma consists of the fat to stroma ratio 90:0. The cassettes are submitted as foliows: A  Superior margin 2 Inferior margin 3 Anterior margin 4  Posterior margin 5  Medial margin 6 Lateral margin 7-10  Representative sections of the tumor 11 Area of fibrosis 12 Breast parenchyma between the tumor and fibrosis.. J. Received in formalin and labeled *additional deep margin (perm)~ consists of two yellow fragments soft in consistency measuring 1 x 0.3 x 0.3 cm in aggregate. The entire specimen is submitted in toto in two cassettes. K. Received In formalin and labeled 'right axillary contents (perm)" consists of a yellow brown soft tissue measuting 9 x 7 x 2 cm. Ten possible lymph nodes are extracted from the specimen and submitted in six cassettes. One lymph hode which measures 1 x 0.5 x 0.3 cm, bisected and submitted in cassette 1. 2 One lymph node bisected. 3 Two lymph nodes 4&5 Three lymph nodes 6 One lymph node L. Received in formalin and labeled "left breast tissue (perm)" consists of a breast mass measuring 465 grams $nd measures 8 x 5 x 2 cm in greatest dimension. It has a skin ellipse which measures 4 x 1.5 cm. The entire specimen other. than skin is inked black. Serial sectioning of the mass it reveals fibrofatty tissue with fat to stoma ratio 70:3o. No gross lesions are identified. 1-5  Representative section of the fibrofatty tissue 6  Skin tag ICD-9(s): 174.8 196.3 Page 4 of 4
\ No newline at end of file
diff --git a/output/text/427a212f-81ea-4d17-8503-f359c64fd610.txt b/output/text/427a212f-81ea-4d17-8503-f359c64fd610.txt
new file mode 100644
index 0000000000000000000000000000000000000000..659c315bdefd2f349c67a7e929a4af1b75ee23a5
--- /dev/null
+++ b/output/text/427a212f-81ea-4d17-8503-f359c64fd610.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+UUID:9529CF47-D435-4CA9-B8B4-069CA2FCD3CD TCGA-CC-A3M9-01A-PR Redacted Irb approved Form Revised Clinical Case Report (For Collection of Cancerous Tissue) Ics-u-3 Criteia Sit: lin c22.0 1/312 s PrimaryNote QUALIFIED ISQUALiFIE Informed Consent I personally informed this patient that a specimen(s) would be collected to be used for research. purposes.I reviewed the RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator Signature Dale Clinical Information GENERAL INFORMATION Date of Birth (mm/dd/yyy) Height Marital Status Race T-mperature  SinglexIMarried Gender Weight  Divorced  Widow Bkood Pressured Heart Rate Male  Female HISTORY OF PRESENT ILLNESS Symptoms: Wei ghif. Coss Clinical Findings:. Performance Scale (Karnofsky Score):  100 Asymptomatic  80-90 Symptomatic but Fully Ambulatory  60-70 Symptomatic, in bed less than 50% of day  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden   20-30 Bed Ridden CURRENT MEDICATIONS Drug Dose  Route Frequency Date (mm/dd/yyyy) / To / To 1 To 1 To / To
+
+--- Page 2 ---
+PAST MEDICAL HISTORY  Diagnosis/Disease/Disorder/Injury  Diagnosis Date Treatment Status OB/GYN HISTORY Menopausal Status Date of First Menses # of Pregnancies  Pre-menopausal  Peri-Menopausal Date of Last Menses # of Live Births  Post-menopausal Birth Control:  Condom Oral Contraceptive IUD  Hormone Replacement  Other: Therapy: SOCIAL HISTORY:  ... Occupation: Environmental Hazards: Smoking History Current Status TypE Packs/day. Duration When Quit LeTAcus S/YES  NO (yrs)  (vr) Alcohol Consumption Current Status TYPE Drinks/day Duration When Quit  donk [?a) YES J nO 1D (yrs) (yr Drug Use TyPE Frequency Duration When Quit Current Status  YES NO (vs) (x) :..* FAMILY MEDICALHISTORY Relative  Diagnosis Age of Diagnosis. LAB DATA Result Test Result Date Test Date HIV Negative  Positive: CEA  Negative  Positive: Hep B  Positive: CA 15-3  Negative  Positive: Negative Hep C CA 19-9 EDNegative  Positive:  Negative  Positive: AFP  PSA   Negative  Positive: Negative  Positive: Other: Other:  Negative  Positive:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+DIAGNOSTIC STUDIES Study Results Date Ultrasound  A t msus Way fouse! Ho live X-Ray CT Endoscopy MRI Biopsy CLINICAL DIAGNOSIS  : Preoperative Clinical Diagnosls Location of Suspected Involved Lymph Nodes. Location of Suspected Distant Metastasis. Clinical Staging Date of Diagnosis t3 No mo Stage: IIL A Treatment Information  SURGICAL TREATMENT: Procedure Date of Procedure Perecta^m Ds asht Lives.. 0 Primary Tumor 1 Organ Detalled Location Size liyek EunersR RjgFi7 LiseR [5 xL x 3 cm Extension of Tumor Lymph Nodes Description Location of Lymph Nodes # of Lymph Nodes Palpable, Non-Dissected Lymph Nodes. Dissected Lymph Nodes Distant Metastasis  Organ Detaiied Location Size Surgical Staging NO m O Stage: L NEOADJUVENT THERAPY (Chemo, Radistion, Immuno, Hormonal, or Molocular) Drug/Treatment Dose Route Frequency Date (mm/dd/yyyy) To To / 1 1 To 1 1 1 / To 1 / 1 To 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by: Date: Time: Preserved by: Date Time: SPECIMEN TYPE (# of samples provided) . Frozen Paraffin Biock Blood/Serum/Piasms Slide Diseased  Normal Diseased Normal Diseased Normal Diseased Normal 4 2 4 2 4 2 Time to LN2 Time to Formalin Time to LN2 min min min PATHOLOGICAL DESCRIPTION : Primary Tumor Organ  Size Extension of Tumord Distance to NAT livee TemiR 5x+x3 cm Lver 6 Ri cm Lymph Nodes Location # Examined # Metastasized Distant Metastasis  Organ Detailed Location Size Pathological Staging No m o pT 3 Stage: Notes: 4
+
+--- Page 5 ---
+Microscopic Descriotion Histo logical Patter  a Cell Distribution +. Structural Pattem +  Diffuse  Streaming  Mosaic  Storiform Necrosis Fibrosis Lymphocytic Infiltration  Palisading Vascular Invasion Cystic Degeneration Clusterized Bleeding Alveolar Formation Myxoid Change  Indian File  Psammoma/Cakification Cellnlar Differentiation?? Squamous + Adenomatous -  Sarcomatous + Lymphomatous  Squamoid Cell Glandular cell x Round Cell  Large Cell Spindle Cell Cell Stratification. Fibroblast Small Cell Keratin Secretion Osteoblast RS Cell/RS Like  Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell  Pear!  Gland formation Myoblast  Plasma Cell Cellular Differentiation: Well Moderate  Poor Nuclear Appearance+ ae* Nuclear Atypia: 0 I II III  Aniso Nucleosis x Hyperchromatism Nucleolar Prominent  Multinucleated Giant Cell x Mitotic Activity Nuclear Grade: IHC Datas it Marker Result Value Date ER  Negative  Positive PR  Negative Positive  Her-2/neu Negative  Positive B-Cell Marker  Negative  Positive T-Cell Marker  Negative  Positive Other:  Negative Positive Other: Negative  Positive Final Pathology Report Histological Diagnosis: tedoTeceero nm lifHenouFi'cn(icd!) pT3NpWr Grade:3. Comments: incipal Investigator "Pathologist Date 5
+
+--- Page 6 ---
+COnsOLIdateD DIAgnOsTIC pathoLOgy fOrm* Microscopic Appearance: Histological pattern: . CELL DISTRIBUTION Diffuse t STRUCTURALPATTERN X Streaming + Mosaic Storiform Necrosis Fibrosis Lymphocytic Infiltration Palisading Vascular Invasion Cystic Degeneration Clusterized X Bleeding Alveolar Formation Myxoid Change Indian File Psanmoma/Calcification 2. Celiular features: Squamous Adenomatous + Sarcomatous Lymphomatous Squamoid Cell Glandular cell Round Cell Large Cell Spindle Cell x Cell Stratification X Fibroblast Small Cell  Keratin Secretion Osteoblast RS CcIV/RS Like  Desmosome Intracyt. Yacuole Lipoblast Inflam. Cell  Peart  Gland formation  Myoblast Plasma Cell Otherwise Specified: D 207 Dr 70% P37Y by 7O7j D seeesks *s 2.Cellular Differentiation: Well Moderaicly Nuclear Atypia: Nuckar Appearance 11 Aniso Nucleosis X Hyperchromatism .4  Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity Nuckear Grade /e. Histological Diagnosis: Hene tocel/er las C@ndosra Sp'sd Comments: Date Director, Research Pathology 'ATHOLOGIST STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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diff --git a/output/text/42ccc9af-3109-49da-b3f9-2fc45422b03c.txt b/output/text/42ccc9af-3109-49da-b3f9-2fc45422b03c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..923898353fd582178c2ad03bb94d50b37a8b416c
--- /dev/null
+++ b/output/text/42ccc9af-3109-49da-b3f9-2fc45422b03c.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:F7BB999F-7D85-4547-A65A-9409FD7C0CEC TCGA-UZ-A9Q1-01A-PR Redacted SURGICAL PATHOLOGy REPORT Final Pathologic Diagnosis A: Subcutaneous mass, excision: Epidermat inclusion cyst.. B: Kidney, teft, adrenal sparring nephrectomy: 1. Papillary renal cell carcinoma, type 2, grade 2, 4.6 cm, see comment.. 2. Simple renal cyst. Comment: Kidney Tumor Synoptic Comment - Histologic type: Renal cell carcinoma, papillary (chromophil) type. ID0-3 - Grade: Fuhrman grading for RCC: grade 2. - Tumor size: 4.6 cm. - Site within kidney: Upper pole. uQQ 826c|3 - Renal pelvis: Normal. - Ureter: Normal. - Renal sinus: Normal. - Hilar renal veins: Normal. QSBI30|14 - Intrarenal veins and lymphatics: Normal. - Adrenal gland: Not present - Capsule/perirenal fat: Tumor does not penetrate capsule. - Lymph node status: None present. The hilar fat was searched for lymph nodes and none wer found.. - Resection margins: Negative. - Ureter: >1cm. - Renal vein: >1 cm. - Soft tissue: Negative, 0.2 cm (see slide 89) - Renal parenchyma: Negative, tumor is 0.2 cm from the renal parenchymal margin (see slide 87) - Proximity to nearest margin:  0.2 cm. - A3CC Stage:pT1bNxMx. Specimen(s) Received
+
+--- Page 2 ---
+A:Subcutaneous mass 8:Left kidney (fresh) Cllnical History The patient is an female with a ieft kidney mass which is solid and cystic in the left upper. pole. This lesion is greater than 5 cm. Additionally, there is a second lesion in the interpolar region. The patia.t also has a 2.4 cm lesion in the liver. She now undergoes a left laparoscopic nephrectomy Gross Description The specimen is received fresh in two parts, each labeled with the patient's name and medical record number. Part A, additionally labeled "subcutaneous mass,* consists of three fragments of white and yellow soft tissue measuring 1.5 x 0.7 x 0.3 cm in aggregate. These fragments are entirely submitted in cassette A1. Part B, additionally labeled "left kidney," consists of a 236 gram, 14 x 6 x 6 cm kidney with a small. amount of perinephric fat. The superior pole has a 4.6 cm, red to yellow soft mass with solid and liquefied areas within 0.3 cm of the pelvis and abutting the renal capsule over much of the tumor. The tumor is suspicious for invasion into the renal capsule grossly. Additionally a second lesion is identified in the interpolar region of the kidney, which is entirely contained in the cortex and does not appear to invade. This lesion is composed of a cyst-like space measuring 2.4 cm. Cassettes are submitted as follows: Cassette B1: Pelvic margin vessels and ureter. Cassette 82: Pelvis with red to yellow mass. Cassette 83: Cystic lesion to pelvis.. Cassette B4: Normal pelvis. Cassette B5: Parenchyma with vessels. Cassettes B6-88: Tumor with capsule. Cassettes B9-810: Extrarenal soft tissue.. Diagnosis based on gross and microscopic examinations. Final diagnosis made by attending pathologist. following review of all pathology slides.. Electronically signed out or. 14114
\ No newline at end of file
diff --git a/output/text/42dd4eea-b5af-4c8a-ab9d-c540a44de3ec.txt b/output/text/42dd4eea-b5af-4c8a-ab9d-c540a44de3ec.txt
new file mode 100644
index 0000000000000000000000000000000000000000..94a3ebf1a408279e1bfb3c335f375088c5dbc57a
--- /dev/null
+++ b/output/text/42dd4eea-b5af-4c8a-ab9d-c540a44de3ec.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Chiet of Fatholoyy Phon. Yax Specimen: Received: Status: Spec Type: SURGICAL P Subm Dr: PRROPURATLVE DIAGNOSIS Jcs-0- 3 Carcinomn,nfiltnatrg duct end 1etuler 85xx13 RIGHT BREAST CANCER INVASIVE Si`n, hrst Nos C50.9 1/37/1 OPERATION PERFORMED DATE: DOcTOR(s) : PROCEDURE: MASTECTOMY PARTIAL/LUMPECTOMY/RXISION SRNTINEL.. TISSE REMOVED A. RT BREAST B. RT SENTINEL NODE #1 UUID:CEFD12BB-1AF7-400D-8A84-49650DFDD8A5 TCGA-A2-A0YI-01A-PR C. RT NON SENTINEL NODE Redacted RT SENTINEL NODE #2 E. RT BREAST ADDITIONAL POST INK NEW MARGIN PART A  RECEIVED LABELED RIGHT BREAST 10 O'CLOCK LONG EQUALS LATERAL SHORT EQUALS SUPERIOR, IS AN OVOID PORTION OF YELLOW FATTY TISSUE MEASURING 9.5 X 6.3 X 4.0 CM. THE SPECIMEN IS ORIENTED BY TWO SUTURES AND BLUE DYE IS NOTED WITHIN THE SPECIMEN. SUPERFICIALLY ON THE LATERAL ONE-HALF, THERE IS A SKIN ELLIPSE MEASURING 4.2 X 0.8 CM. NEEDLE LOCALIZATION WIRES ENTER THE INFERIOR LATERAL ASPECT OF THE  TWO SPECIMEN. SECTIONING REVEALS THE MAJORITY OF THE SPECIMEN TO CONSIST OF BLAND YELLOW FATTY TISSUE WITH FINE FIBROUS BANDS. THE SPECIMEN, THERE IS A PINK-TAN GRITTY AREA. THIS IS IN THE MEDIAL  IN THE MIDPORTION OF ONE-HALF, AND LATERAL TO THIS, THERE IS DENSE PINK-TAN FIBROUS TISSUE. THE FIRM AREA MEASURES 1.7 X 1.4 X 2.0 CM IN GREATEST DIMENSIONS. IS A SECOND FIRM AREA IMMEDIATELY INFERIOR TO THIS AREA WHICH BY THERE PALPATION MEASURES O.7 CM IN GREATEST DIMENSION. THIS APPROACHES THE INFERIOR MARGIN BY O.3 CM. THE LARGER LESION IS 1 CM FROM THE CLOSEST MARGIN, WHICH IS SUPERFICIAL AND DEEP. SECTIONS ARE SUBMITTED AS FOLLOWS: A1--PERPENDICULAR MEDIAL MARGIN, A2--PERPENDICULAR LATERAL MARGIN, A3--CENTRAL TUMOR (MIRROR IMAGE TO PROTOCOL). A4 THROUGH A8--TISSUE SURROUNDING A3 AS FOLLOWS: DEEP MARGIN, INFERIOR MARGIN TO INCLUDE SEPARATE PALPABLE NODULE, A6--SUPERFICIAL INFERIOR ASPECT, A7--SUPERFICIAL MARGIN, A8--SUPERIOR MARGIN. A9 AND 10--FULL CROSS-SECTION OF LESION TO INCLUDE THE DEEP AND SUPERFICIAL MARGINS, RESPECTIVELY; A11--LATERAL ASPECT OF LESION TO INCLUDE SUPERFICIAL MARGIN (MIRROR IMAGE TO PROTOCOL). PART B  RECEIVED FRESH LABELED, RIGHT SENTINEL NODE #1 HOT AND BLUE, ARE TWO PORTIONS OF YELLOW-PINK FATTY TISSUE MEASURING 1.7 X 1 X 0.5 CM AND 1.7 X 1.5 X 0.8 CM. IN THE SMALLER PORTION, THERE IS A 0.6-CM GROSSLY UNREMARKABLE LYMPH NODE. THE LARGER PORTION CONSISTS OF FATTY TISSUE WITH FOCAL BLUE DYE. BLUE DYE IS ALSO NOTED WITHIN THE NODE. THE SPECIMEN IS SUBMITTED ENTIRELY LABELED B.
+
+--- Page 2 ---
+Phont tax Patientr (Contlnued) Specimen: Received: Status: Spec Type: SURGICAL P OROSS DESTR! Subm Dr: (Continued) PART C RECEIVED FRESH LABELED NODE, IS AN OVOID PORTION OF PINK-TAN TISSUE MEASURING 1.8 X 1 X 1 CM. RIGHT NONSENTINEL LYMPH SECTIONING REVEALS IT TO BE A GROSSLY UNREMARKABLE LYMPH NODE. A PORTIONS IS SUBMITTED PER PROTOCOL.  THE REMAINDER IS SUBMITTED LABELED C. PART D RECEIVED FRESH LABELED AN IRREGULAR PORTION OF YELLOW-RED FATTY TISSUE MEASURING 2.5 X 1.5 X 1.0 SENTINEL NODE #2 HOT, IS CM. NO DISTINCT NODAL TISSUE IS IDENTIFIED. SUBMITTED LABELED D. THE SPECIMEN IS ENTIRELY PART B RECEIVED LABELED POSTERIOR INK AT NEW MARGIN, IS AN OVOID PORTION OF YELLOW FATTY TISSUES RIGHT BREAST ADDITIONAL MEASURING 6 X 4.8 X 0.8 CM.  THE SIDE OF THE SPECIMEN WHICH DEMONSTRATES THE INK IS MARKED WITH BLUE INK WITH A PERIMETER OF BLACK INK. SECTIONED AND SUBMITTED ENTIRBLY LABELED E1 THROUGH 9. THIS IS PROCEDURES : 88305, 88307/4, IMMUNOPEROXIDAS/2, A BLK/11, BBX X6, C BLK, DBX X6, E BLK/9 PART A RIGHT BREAST, PARTIAL MASTECTOMY: MODERATELY DIFFERENTIATED IN SITU AND INFILTRATING CARCINOMA WITH MIXED DUCTAL AND LOBULAR DIFFERENTIATION, PREDOMINANTLY LOBULAR, NUCLEAR GRADE I WITH LOW MITOTIC INDEX, WITH AN IN SITU COMPONENT OF APPROXIMATELY 2Ot OF SOLID AND CRIBRIFORM TYPE. 2. TWO (2) TUMOR NODULES ARE PRESENT MEASURING 1.7 AND 0.5 CM IN GREATEST DIMENSION. ALL MARGINS OF RESECTION ARE FREE OF NEOPLASM BY A DISTANCE OF 5 MM OR GREATER. 3. LYMPHATIC INVASION IS NOT IDENTIFIED. 4. FIBROCYSTIC DISEASE. 5. BIOPSY SITE CHANGE WITH ORGANIZING FAT NECROSIS AND REACTIVE FIBROSIS. PART B RIGHT SENTINEL NODE #1, BIOPSY: LYMPH NODE (1) WITH A MINUTE FOCUS OF ISOLATED TUMOR CELLS WHICH IS ONLY VISIBLE ON CYTOKERATIN STAINS AND NOT ON THE ROUTINE STEP SECTIONS. THE FOCUS OF TUMOR CELLS MEASURES APPROXIMATELY O.05 MM IN GREATEST DIMENSION. PART C RIGHT NONSKNTINEL LYMPH NODE, BIOPSY: LYMPH NODE (1) WITH FATTY INFILTRATION, NEGATIVE FOR TUMOR. PART D RIGHT SENTINEL NODE #2, BIOPSY: ADIPOSB TISSUE CONTAINING A
+
+--- Page 3 ---
+Chief of tatholosy Phone Fax (eon Specimen: Received: Status: Spec Type. SURGICAL P Subm Dr: DIAGNOSES (Continued) MINUTE CRUSHED LYMPHOID AGGREGATE, NEGATIVE FOR TUMOR BY STEP SECTION AND CYTOKERATIN STAIN. PART E RIGHT BREAST, ADDITIONAL POSTERIOR MARGIN: LIPOMATOUS BREAST TISSUE WITH NO EVIDENCE OF RESIDUAL NEOPLASM. THE NEW INKED MARGIN IS FREE OF NEOPLASM.  FIBROCYSTIC CHANGE WITH DUCT HYPERPLASIA OF THE USUAL TYPE WITH INTRADUCTAL PAPILLOMATOSIS, APOCRINE METAPLASIA AND CYST FORMATION. 1 Signed (prelim.) (signature on file) Mxesd- duetl + Ithule
\ No newline at end of file
diff --git a/output/text/42dfcedd-0d2e-4abb-aa55-e7d163b0ec1d.txt b/output/text/42dfcedd-0d2e-4abb-aa55-e7d163b0ec1d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e3c3161248371f3a20872eae459dde9d6cf099a4
--- /dev/null
+++ b/output/text/42dfcedd-0d2e-4abb-aa55-e7d163b0ec1d.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+IcD 0 3 Careuntrnd, sepateWIulsr 817C/3 UUID:A993CEA3-6AA2-4CE7-A9EC-8318B1377E99 TCGA-DD-AAC9-01A-PR Redacted Sute suur C&Q.O 9tJ s/19/4 CLINICAL DIAGNOSIS: HCC Specimen : liver Gross Photo : GROSS: 1. Specimen: Liver: 7.0 x 8.5 x 5.0 cm, 93.5 g, unfixed 2. Tumor location: segment 8 Tumor number: one Tumor size: 2.9 x 2.2 x 2.8 cm 3. Satellite nodule: no 4. Gross type  HCC: vaguely nodular 5. Tumor necrosis: no 6. Hemorrhage/peliosis: no 7. Portal vein invasion: no 8. Bile duct invasion: no Gross photo present. Blocks T1-4, tumor mass x 4 RM, resection margin x 1 MICROSCOPIC: 1. Hepatocellular carcinoma: yes 1-1. Differentiation The worst differentiation II The major differentiation II 1-2. Histologic type: trabecular, pseudoglandular 1-3. Cell type: hepatic 1-4. Fatty change: no 2. Cholangiocarcinoma: no 3. Combined hepatocellular and cholangiocarcinoma: no. 4. Other tumor: no 5. Fibrous capsule formation: partial capsule 6. Capsular infiltration: yes 7. Septum formation: yes 8. Surgical resection margin invasion: no, margin of the clearence O.5 cm 9. Serosal invasion: no 10. Portal vein invasion: no. 11. Bile duct invasion: no
+
+--- Page 2 ---
+12. Hepatic vein invasion: no 13. Hepatic artery invasion: no 14. Microvessel invasion: no 15. Intrahepatic metastasis: no 16. Multicentric occurrence: no Non-tumor liver pathology. 1. Chronic hepatitis: yes. 1-1. Etiology: HBV 1-2. Grade, lobular: minimal 1-3. Grade, portoperiportal: mild 1-4. Stage (fibrosis): cirrhosis 1-5. Cirrhosis: micronodular 2. Dysplastic nodule: no 3. Ductal epithelial dysplasia: no 4. Other liver diseases: no. SPECIAL STAIN: Trichrome (positive, stage 4) Small intestine, duodenum, scopic, Chronic inflammation stomach, antrum,scopic, chronic gastritis Liver, ectomy, hepatocellular carcinoma T56000, P10, M81703 DIAGNOSIS Liver, segment 8, segmentectomy: Hepatocellular carcinoma, moderately differentiated Suggestion : 43/14
\ No newline at end of file
diff --git a/output/text/42f48b55-fc1d-4a60-b71c-882acc4ec748.txt b/output/text/42f48b55-fc1d-4a60-b71c-882acc4ec748.txt
new file mode 100644
index 0000000000000000000000000000000000000000..76b38d98fc05238551f33983e05136cabb8fcb17
--- /dev/null
+++ b/output/text/42f48b55-fc1d-4a60-b71c-882acc4ec748.txt
@@ -0,0 +1,24 @@
+
+--- Page 1 ---
+UUID:CFF567FC-8867-4CA4-85AE-81A7D30095E70 Redacted 1c0-0 -3 Cacnomn nifiltrshxg 1obu1ev avd cluctl 85 3s/3 Site: hrast, niis C50.9 Fina! Pathologic Diagnosis: A. Right breast, biopsy: No evidence of tumor in one lymph node (0/1).. B. Left axilla, sentinel lymph node #1, dissection: No evidence of tumor in three lymph nodes (0/3). C. Right breast, mastectomy: 1. Skin with no significant pathologic abnormality. 2. Proliferative fibrocystic changes.. 3. Microcalcifications in association with benign glands.. D. Left breast, mastectomy: 1. Invasive carcinoma, 2.0 cm, SBR grade 2, see comment.. 2. Ductal carcinoma in situ, low grade, see comment.. 3. Skin with no significant pathologic abnormality. 4. Fibroadenoma. 5. Microcalcifications associated with invasive carcinoma and benign glands.. 6. Proliferative fibrocystic changes.. Page I ot'3
+
+--- Page 2 ---
+Surgical Pathology Working Draft 7. Papillomatosis. 8. Pseudoangiomatous stromal hyperplasia. E. Nonsentinel lymph node, left axilla, dissection: No evidence of tumor in four lymph. nodes (0/4). F. Right breast, re-excision of superior portion: Benign breast parenchyma. Note: In Part D (left breast), the area indicated by the surgeon with a green stitch shows proliferative fibrocystic changes, sclerosing adenosis, and pseudoangiomatous stromal hyperplasia. There is no evidence of carcinoma in the area around the green suture.. Breast Tumor Synoptic Comment - Laterality: Left. - Invasive tumor type: Mixed ductal and lobular type (tumor is present in Slides D1, D2, DS, and D18) - Invasive tumor size: 2.0 cm maximum diameter (Slide D5).. - Invasive tumor grade (modified Bloom-Richardson): Nuclear grade: 2 points. Mitotic count: 16 mitotic figures/10 HPF, 2 points. Tubule/papilla formation: Definite tubule formation <10%, 3 points.. Total points and SBR grade - 7 points, grade 2. - Lymphatic-vascular invasion: None identified. - Perineural invasion: None identified. - Resection margins for invasive tumor: - Deep margin: Positive (Slide D2, 5). - Medial margin: Widely clear; >1 cm. - Lateral margin: Widely clear; >1 cm. - Anterior/superior margin: Widely clear; >1 cm. - Anterior/inferior margin: Widely clear; >1 cm. - Ductal carcinoma in situ (Dcis) type: Solid. - Ductal carcinoma in situ size: DcIS present as scattered microscopic foci associated with the invasive component on Slides DI and D2. - Ductal carcinoma in situ nuclear grade: Low grade. - Necrosis in ductal carcinoma in situ: None. - Microcalcifications: Present involving invasive carcinoma.. - Resection margins for ductal carcinoma in situ: - Deep margin: Ciose; within less than 0.3 cm (Slide D1).. - Medial margin: Widely clear; >1 cm. - Lateral margin: Widely clear; >I cm. - Anterior/superior margin: Widely clear; >1 cm. - Anterior/inferior margin: Widely clear; >1 cm. - Lobular carcinoma in situ (LCiS): Not identified. - Lymph node status: No evidence of tumor in eight lymph nodes (O/8). - AJCC/UICC stage: pT1cNOMX. - Nontumorous breast tissue: Proliferative fibrocystic changes, Fibroadenoma, pseudoangiomatous hyperplasia. - Nipple: Unremarkable. - Skin/dermis: Unremarkable. Immunohistochemical tests for estrogen, progesterone and Her2 Neu are pending and will follow in an. addendum. Intraoperative Consult Diagnosis FS1 (A) Right breast nodule, biopsy: Lymph node with no tumor seen. (Dr.. FS2 (B) Sentinel lymph node, left axilla, biopsy: Three lymph nodes, no tumor seen. (Dr.. Page 2 of 8
+
+--- Page 3 ---
+Surgical Pathology - Working Draft Clinical History The patient is a year-old woman with breast cancer. A. tracking sheet accompanies the specimen and indicates a high family risk for cancer and preoperative diagnosis of known left breast cancer in the upper outer quadrant. No specimen radiograph is requested. Multifocality is suspected on the left side. Special stains for ER, PR, and HER2/neu are requested as a repeat. The diagram indicates that the known tumor is in the upper outer quadrant of the left breast, and a suspicious area is present in the upper inner quadrant at approximately the 11 o'clock position above the nipple. Recent MRI indicates the presence of a known 2-cm tumor with clip present in the lateral breast of the left breast in addition to an adjacent 5-mm lesion that is immediately posteromedial to the primary lesion. A 5-mm suspicious area is also identified in the slightly upper inner quadrant.. Gross Description The specimen is received in six parts, each labeled with the patient's name and medical record number. Parts A through D and F are received fresh, and Part E is received in formalin.. Part A is additionally labeled "right breast nodule." It consists of a single unoriented, irregular piece of soft, pink tissue, measuring 0.7 x 0.5 x 0.3 cm. The specimen is entirely submitted for frozen section diagnosis as FS1, with the frozen section remnant submitted in cassette A1.. Part B is additionally labeled "sentinel lymph node left axilla, count - 180o, frozen section.* It consists of a single irregular piece of soft, yellow-pink, fatty tissue, measuring 3.0 x 2.0 x 0.6 cm. The specimen is entirely submitted for frozen section diagnosis as FS2, with the frozen section remnant submitted in cassette B1. Part C is additionally labeled "right breast." It consists of a mastectomy specimen, oriented with a short suture considered superior and long suture considered lateral; oriented as such, the specimen measures 3.2 cm from anterior to posterior, 14.7 cm from medial to lateral, and 13.7 cm from superior to inferior. The mastectomy specimen weighs 212.5 gm. The specimen includes an area of skin, measuring 14.5 x 6.7 cm, with nipple, measuring 1.7 x 1.7 x 1.5 cm, and areola. measuring 3 x 3.8 cm. The specimen has been previously inked and serially sectioned by the serial slices. Inking follows standard inking, with posterior black, anterior superior blue, and anterior inferior green. The accompanying research paperwork indicates that a fragment of tissue has been taken for tissue banking. Cut sections reveal that the breast is composed almost entirely of homogeneous, firm, white, fibrous tissue that abuts the deep margin. Thin layers of adipose tissue are present in the anterior surface as well as the medial aspect of the specimen. No grossly evident lesions are identified. The nipple and skin similarly appear unremarkable. Slice 1 is considered medial, and slice 10 is considered lateral. The nipple, thereby, is in slice 5. Representative sections are submitted as follows:. Cassettes C1-C2: Nipple, entirely submitted. Cassette C3: Upper outer quadrant from slice 8. Cassette C4: Upper outer quadrant from slice 7.. Cassette C5: Lower outer quadrant from slice 8. Cassette C6: Lower outer quadrant from slice 7. Cassette C7: Upper inner quadrant from slice 4.. Cassette C8: Upper inner quadrant from slice 3. Cassette C9: Lower inner quadrant from slice 3.. Cassette C10: Lower inner quadrant from slice 2 and section of skin from slice 4.. Part D is additionally labeled "left breast," with further specification in the requisition form indicating that a green stitch - questionable secondary cancer, correlate with MRI, and black short - superior, long - lateral. A firm, pale-tan, circumscribed lesion, measuring 1.6 x 1.2 x 1.4 cm, is present at the 3 o'clock position, 3 cm from the nipple; this contains a surgical clip. The lesion is 0.1 cm from the deep margin, 0.9 cm from the skin, 2.2 cm from anterior superior, 1.9 cm from anterior inferior, 3.5 cm from the lateral margin, and <10 cm from the medial margin. Immediately inferior and medial to main lesion, a 0.4-cm area contains multiple punctate, firm, yellow spots. This lesion is 0.5 cm from the large lesion and is 0.5 from the deep margin. The remainder of the specimen is composed mostly of firm, fibrous tissue, showing multiple. small cystic areas, with a maximum diameter of O.4 cm, throughout. The area adjacent to the green suture on slice 6 similarly consists of dense, fibrous tissue, and no definitive lesions are identified in this area. The skin, nipple, and areola appear unremarkable.
+
+--- Page 4 ---
+Surgical Pathology  Working Draft Accompanying paperwork from the ' : ndicates that a portion of the. specimen has been taken for tissue banking. The specimen contains a short stitch and long black stitch, taken to be superior and lateral, respectively, and has been previously inked and sectioned by the research technician into ten slices, from medial to lateral. Inking is as per standard, with posterior in black, anterior superior in blue, and anterior inferior in green. The blue ink appears faint. The most-medial slice is taken as slice 1 and the most-lateral slice as slice 10. The specimen, thereby, measures 2.5 cm from anterior to posterior, 15.6 cm from medial to lateral, and 16.6 cm from superior to inferior and weighs 192.5 gm. A skin ellipse is present, measuring 6.6 x 13.1 cm, with the long axis in the mediolateral extent. The areola measures 3.4 x 3 cm, and the nipple measures 1.8 x 1.6 x 1.6 cm. The nipple lies in slices 5 and 6. The green nylon suture is in the posterior aspect of slice 6 at the 12 o'clock. position, 3.5 cm superior to the nipple. Representative sections are submitted as follows: Cassette D1: 1.6-cm lateral lesion in relation to deep margin from slice 8. Cassette D2: Punctate, yellow lesion from slice 8. Cassette D3: Nearest anterior-superior margin in slice 8. Cassette D4: Nearest anterior-inferior margin from slice 8. Cassette D5: Additional 1.6-cm lesion in relation to skin. Cassettes D6-D7: Nipple, entirely submitted.. Cassette D8: Area marked by green suture, including skin and anterior-superior and deep margins. Cassettes D9-D11: Additional sections of area marked by the green suture en bloc from slice 6.. Cassette D12: Area adjacent to green suture from slice 5. Cassette D13: Area adjacent to green suture from slice 7. Cassette D14: Inferior margin of slice 8. Cassette D15: Superior margin of slice 8.. Cassette D16: Lateral margin from slice 10. Cassette D17: Medial margin from slice 1.. Cassette D18: Intervening area between primary lesion and lateral margin from slice 9. Cassette D19: Upper inner quadrant, rectangular from slice 4 and triangular from slice 3.. Cassette D20: Lower inner quadrant, rectangular from slice 5, triangular from slice 4. Cassette D21: Upper outer quadrant, rectangular from slice 8, triangular from slice 9 Cassette D22: Lower outer quadrant, triangular from slice 7, rectangular from slice 9.. Part E is additionally labeled "nonsentinel lymph node left axilla." It consists of a single unoriented fragment of largely adipose tissue, measuring 2.4 x 1.4 x 0.5 cm. A single 1.4-cm lymph node is identified. The candidate lymph node is bisected and entirely submitted in cassette E1. The remainder of the soft tissue is entirely submitted in cassette E2. Part F is additionally labeled "re-excision superior portion right breast" and has an additional note in the requisition form indicating that the stitch - new margin. It consists of a single fragment of adipose tissue, measuring 3 x 2.2 x 0.9 cm, marked by a single black suture. The surface containing the black suture is inked in black and the opposite surface in blue. The specimen is serially sectioned to reveal mostly adipose tissue, with a single 0.7-cm area of white, fibrous tissue. The specimen is entirely submitted in cassettes F1 through F3. /Pathology Resident /Pathologist Signed: Fee Codes: Addenda Addendum. Date Ordered: Status:  Signed Out Date Complete: By: Date Reported: Paor 4 nf R
+
+--- Page 5 ---
+Surgical Pathology - Working Draft Addendum Comment An immunohistochemical test for estrogen and progesterone receptors as well as for HER2 was performed on block DS. The test for estrogen receptors is positive. There is strong (3+) nuclear staining in 85% of tumor cells.. Internal positive control is positive. The test for progesterone receptors is. There is strong (3+) nuclear staining in~100% of tumor cells. Internal positive control is positive. Result of HER2/neu test: This carcinoma is negative for HER2/neu oncoprotein over-expression.. An immunohistochemical assay was performed using the CB11 monoclonal antibody to HER2/neu oncoprotein. The staining intensity of this carcinoma was 1 on a scale of O-3 (HER2 test interpreted by Dr. . J. Carcinomas with staining intensity scores of O or 1 are considered negative for over-expression of HER2/neu oncoprotein. Those with a staining intensity score of 2 are considered borderline. We and others have observed that many carcinomas with staining intensity scores of 2 do not show gene amplification. All carcinomas with staining intensity scores of 2 are therefore submitted for FISH testing. The results of the FiSH test are issued directly from the molecular cytogenetics laboratory. Carcinomas with staining intensity scores of 3 are considered positive for over-expression of HER2/ncu oncoprotein. Tumors in this category show an excellent correlation between the results of immunohistochemical and FIsH testing, and almost always show gene amplification. The immunoperoxidase stain(s) reported above were developed and their performance characteristics determined by the. They have not been cleared or approved by the U. S. Food and Drug Administration. 1ne FDA has determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 ("CLIA") as qualified to perform high-complexity clinical testing. /Pathologist Electronically signed out on Addendum. Date Ordered: Status: Signed Out Date Complete: By: Date Reported: Addendum Comment An immunohistochemical test for progesterone receptors was performed on block D5. The test for progesterone receptors is positive. There is strong nuclear staining in -1o0% of tumor cells. The immunoperoxidase stain(s) reported above were developed and their performance characteristics determined by the. :. They have not been cleared or approved by the U. S. Food and Drug Administration. The FDA nas determinea tnat such. ciearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 ("CLIA")  as qualified to perform high-complexity clinical testing. Pathologist Electronically signed out on Page S of 8
+
+--- Page 6 ---
+Surgical Pathology. Working Draft Other Specimens Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Rectal, polyp. Final Diagnos Rectum, polypectomy: Hyperplastic polyp. Specimen Class: Status: Signed Out Accessioned: Specimen(s) Received: Pelvic Washinge Stgned Out: Final Diagnosis Pelvic Washing BENIGN. Reactive mesothelial cells. Specimen Class: Status: Signed Out Accessioned: Specimen(s) Received: A: Risk reducing salpingo-oophorectormy- right ovary- Fs, B: Risk reducing salpingo-oophorectormy- Signed Out: left ovary- FS, C: Endometrium, curettage- perm, D: Endocervix, curettage- perm Final Diagnosis A. Right ovary, salpingo-oophorectomy: No significant pathologic abnormality; see comment. B. Left ovary, salpingo-oophorectomy: No significant pathologic abnormality; see comment. C. Endometrium, curettage: Tissue insufficient for accurate evaluation; see comment. D. Endocervix, curettage: Scant fragments of squamous and glandular epithelium with no significant pathologic abnormality. Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Cervical, Thin Prep Jmaged Final Diagnosis Cervical, Thin Prep Imaged. NEGATIVE FOR INTRAEPITHELIAL LESION OR MALIGNANCY. Atrophic pattern Inflammation. Pawr 6 nF R
+
+--- Page 7 ---
+Surgical Pathology Working Draft SPECIMEN ADEQUACY: Satisfactory for evaluation; atrophic pattern with no identifiable. endocervical/transformation zone component.. Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Cervical/Endocervical, Thin Prep Imaged Final Diagnosis Cervical/Endocervical, Thin Prep Imaged NEGATIVE FOR INTRAEPITHELIAL LESION OR MALIGNANCY. Atrophic changes SPECIMEN ADEQUACY: Satisfactory for evaluation; atrophic pattern with no identifiable. endocervical/transformation zone component. Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Left breast core needle biopsy at 2:30, N + 3-4 Final Diagnosis Left breast, needle core biopsy: Invasive carcinoma; see comment.. MD Procedure/Addenda for. ADDENDUm. Date of Addendum.: Addendum Comment Immunohistochemical stain for E-Cadherin was performed and evaluated on A1. The invasive carcinoma shows area with moderate membrane staining and others that are negative or demonstrate granular staining. Thus, this invasive carcinoma displays features of both ductal and lobular carcinoma. Dr.. nas reviewed the immunohistochemical stained slide and concurs.. The immunoperoxidase stain(s) reported above were developed and their performance characteristics. determined by the They have not been cleared or approved by the U. S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 ("CLIA") as qualified to perform high-complexity clinical testing. Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Left Axilla Lynph Node, Fine Needle Aspiration. Page 7 of 8
+
+--- Page 8 ---
+Surgical Pathology Working Draft Final Diagnosis Left Axilla Lymph Node, Fine Needle Aspiration: Benign reactive Iymph node, see note.. This lymph node shows a spectrum of small to large sized lymphocytes with scattered. tingible body macrophages. No evidence of neoplasia is seen. .. Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Left Breast, Fine Needle Aspiration Final Diagnosis Left Breast, Fine Needle Aspiration: Adenocarcinoma, see comment. Procedure/Addenda for AddENdum. Date of Addendum.: Addendum Comment An immunohistochemical test for estrogen and progesterone receptors as well as for HEr-2-neu was performed on the material submitted for cell block. The test for estrogen receptors is positive . There is strong nuclear staining in 90% of tumor cells. The test for progesterone receptors is positive. There is strong nuclear staining in 80% of tumor cells.. Result of HER2/neu test: This carcinoma is borderline for HER2/neu oncoprotein over-expression. An immunohistochemical assay was performed on cell block using the CB1 l monoclonal antibody to. HER2/neu oncoprotein. The staining intensity of this carcinoma was 2 on a scale of 0-3. Carcinomas with staining intensity scores of O or I are considered negative for over-expression of HER2/neu oncoprotein. Those with a staining intensity score of 2 are considered borderline. We and others have observed that many carcinomas with staining intensity scores of 2 do not show gene amplification. All carcinomas with staining intensity scores of 2 are therefore submitted for FISH testing. The results of the FISH test are issued directly from the molecular cytogenetics laboratory. Carcinomas with staining intensity scores of 3 are considered positive for over-expression of HER2/neu oncoprotein. Tumors in this category show an excellent correlation between the results of. immunohistochemical and FIsH testing, and almost always show gene amplification. Dr  has reviewed the HER2/neu stain and concurs. END OF REPORT Paar R nf 8
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diff --git a/output/text/4328dc1f-55f1-48ca-8e37-9bdd266d7da3.txt b/output/text/4328dc1f-55f1-48ca-8e37-9bdd266d7da3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..50967598432defc3f64b913d454eee5546d1ff1f
--- /dev/null
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+
+--- Page 1 ---
+TCGA-5m-AAT6-01A-PR Redacted Date: SPECiMEN: Terminal ileum, cecum, appendix, ascending and transverse colon PROCEDURE: Right hemicolectomy MACROSCOPY - Product of right hemicolectomy. - Segment of terminal ileum, cecum, segment of ascending colon and appendix.. - The serosa is focally irregular, and displays multiple nodules in addition to a perforation 2.0 x 1.5 cm large, which is continuous to an ulcerative, vegetative luminal lesion measuring 8.0 x 8.0 cm, located 8.0 cm from the nearest surgical margin. - The lesion penetrates the colon wall to the serosa. - 11 lymph nodes were dissected from the pericolic fat; sizes ranging from 0.3 to 0.6 cm. MICROSCOPIC EXAMINATION - Moderately differentiated tubular adenocarcinoma of the ascending colon;. - Microscopic tumor extension: invasion of pericolic soft tissues;. - Perineural invasion: present; - Lymph-vascular invasion: present; - Moderate desmoplastic stromal reaction;. - Surgical margins free of neoplastic involvement;. IcD-0:3 - Number of lymph nodes examined: 11;. - Number of lymph nodes involved: 10;. elencarcnonNDS 814o13 - Stage: pT4c/d, pN2 dertcercrsria, tulubar 821/3 PATHOLOGISTS Site: CloerdengycolmsC18.2 QJ sJa/14
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diff --git a/output/text/434ed098-9db0-460a-bf14-ce7c112ece20.txt b/output/text/434ed098-9db0-460a-bf14-ce7c112ece20.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2e2c8baaac748edb0844d52184ce16e86f2e8e2d
--- /dev/null
+++ b/output/text/434ed098-9db0-460a-bf14-ce7c112ece20.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:A910FE6E-4D5B-43F9-88D9-679147FEA50F TCGA-WC-AA9A-01A-PR Redacted Accession: Specimen Date/Time: ICD d 3 Melanoma epundke eeDl No5 8772|3 DIAGNOSIS St: BChcroud (A) RIGHT GLOBE, ENUCLEATION: C49.3 CHOROIDAL MELANOMA, 14 MM BASE, SPINDLED TYPE dO e113|14 SUPERFICIAL SCLERAL INVASION PRESENT. Optic nerve invasion is not identified. Vortex vein is negative for tumor. Extraocular extension is not identified. (See Comment) COMMENT The tumor shows mitotic activity at 3 per 10 high-power fields. A PAS is examined to review the internal ocular structures. GROSS DESCRIPTION (A) RIGHT EYE -- An enucleation specimen consisting of an intact globe (23 x 23 x 22 mm) has an attached optic nerve 5 mm in length. The sclera is unremarkable. The anterior chamber is formed by a gray-blue iris (10 x 11 mm) which surrounds a round 5 mm pupil. The anterior chamber appears clear. By transillumination a shadow is present from 7-11 o'clock witn an approximate base of (14 x14 mm). The shadow corresponds to a choroidal based mass with a height of 6 mm. The tumor is tan to dark brown and appears confined to the globe. The tumor is 3 mm from the optic nerve and 9 mm from the limbus. The vitreous is clear.. Tumor harvest is performed, and the specimen is sectioned in a standard fashion.. SECTtON CODE: A1-A4, vortex veins (superior temporal, superior nasal, inferior nasal, inferior temporal); A5, pupil-optic. nerve section with tumor, A6, calotte with tumor; A7, remaining calotte; A8, optic nerve margin and additional portion of tumor. CLINICAL HISTORYS Choroidal melanoma. SNOMED CODES T-AA000, M-87203 "Some tests reported here may have been developed and performance characteristics determined by These tests have not been specifically cleared or approved by the U.S. Food and Drug Administration." Entire report and diagnosis completed by: -END OF REPORT- 444114
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diff --git a/output/text/435872d4-adc7-42e4-bfae-8d86f4fd16db.txt b/output/text/435872d4-adc7-42e4-bfae-8d86f4fd16db.txt
new file mode 100644
index 0000000000000000000000000000000000000000..abbc0c278fa92a0edf0b1b610f29bc3dcf2d443f
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+5/23 1cs-0 -3 ry Tuinor Site D.scrpar.cy caicin omn, Li fiItrating cluct,nos 85o0f3 Sit: bresst, Nos C 50.9 5/22/ A) LEFT BREAST, TOTAL MASTECTOMY: INVASIVE DUCTAL CARCINOMA, MODIFIED BLACK'S NUCLEAR GRADE 3 bilaterai (POORLy DIFFERENTIATED). (SEE COMmEnT) Lf-ast CA. DUCTAL CARCINOMA IN SITU (DCIS), MODIFIED BLACK'S NUCLEAR GRADE 3 (HIGH GRADE), SOLID AND CRIBRIFORM PATTERNS WITH COMEDONECROSIS. INVASIVE CARCINOMA MEASURES 1.2 X 1.0 X 1.0 CM.  MARGINS WIDELY FREE, INVASIVE CARCINOMA IS PRESENT 2.2 CM FROM CLOSEST INFERIOR MARGIN. No lymphovascular identified. Nipple, no tumor present. (B) LEFT AXILLARY SENTINEL LYMPH NODE #1, EXCISIONAL BIOPSY: One lymph node, no tumor present (0/1). Immunohistochemistry for cytokeratin is negative tor carcinoma. (C) LEFT AXILLARY SENTINEL LYMPH NODE #2, EXCISIONAL BIOPSY: One lymph node, no tumor present (0/1) Immunohistochemistry tor cytokeratin is negative tor carcinoma.. (D): RIGHT BREAST, TOTAL MASTECTOMY: INVASIVE DUCTAL CARCINQMA, MODIFIED BLACK'S NUCLEAR GRADE 3 (POORLY DIFFERENTIATED). (SEE COMMENT) DUCTAL CARCINOMA IN SITU (DCIS), MODIFIED BLACK'S NUCLEAR GRADE 3 (HIGH GRADE). SOLID CRIBRIFORM PATTERNS WITH COMEDONECROSIS AND MICROCALCIFICATIONS INVASIVE CARCINOMA MEASURES 1.4 CM IN GREATEST SLIDE DIMENSION. DCIS PRESENT 0.35 CM FROM LATERAL ANTERIOR MARGIN. INVASIVE CARCINOMA IS PRESENT 0.4 CM FROM LATERAL ANTERIOR MARGIN. FOCAL LYMPHOVASCULAR INVASION PRESENT. Nipple, no tumor present. (E) RIGHT SENTINEL LYMPH NODE #1, EXCISIONAL BIOPSY: One lymph node, no tumor present (0/1). Immunohistochemistry for cytokeratin are negative for carcinoma.. (F) RIGHT SENTINEL LYMPH NODE #2, EXCISIONAL BIOPSY: One lymph node, no tumor present (0/1). Immunohistochemistry tor cytokeratin are negative tor carcinoma.. Entire report and diagnosis completed by COMMENT In specimen A, LEFT BREAST, the invasive carcinoma has areas of lymphocytic infiltration but also has infiltrating borders. Immunohistochemical studies demonstrate that the invasive carcinoma is positive tor CK903, CK5/6 and vimentin.. This report is issued to give immunohistochemistry results. Immunohistochemical staining is pertormed on a representative formalin-tixed, paraffin-embedded section of INVASiVE DUCTAL CARCINOMA, left breast, block A3. MARKER RESULTS % POSITIVE SCORE Estrogen Receptor Low Positive (1-9%) 1 % N/A Progesterone Receptor  Negative 0 % N/A HER-2/neuoverexpression Negative 0 % 0 UUID:E7B75FEC-1706-42C1-8906-B17FE4440161 TCGA-GM-A2DD-01A-PR Redacted
+
+--- Page 2 ---
+This report is issued to give immunohistochemistry results. Immunohistochemical staining is performed on a representative formalin-fixed, paraffin-embedded section of INVASIVE DUCTAL CARCiNOMA, right breast, block D6. SCORE MARKER RESULTS % POSITIVE Low Positive (1-9%) 1 % N/A Estrogen Receptor Progesterone Receptor  Negative 0 % N/A HER-2/neu overexpression Negative focal 5 % 2+ Due to the above HER-2/neu immunohistochemical staining result, gene copy level (heR-2/neu: cep17 signal ratio) will be evaTuated by FISH and'a separate report will be issued.. FOOTNOTE Estrogen receptor was assessed by immunohistochemistry using antibody 6F11 Progesterone receptor was assessed by immunohistochemistry using antibody PgR1294( HER-2/neu was assessed by immunohistochemistry using antibody A88 (l GROSS DESCRIPTION (A) LEFT BREAST, SHORT STITCH SUPERIOR, LONG LATERAL FOR IMMEDIATE CONSULTATION - Received is a 16 x 13 x 3.0 cm breast with attached ellipse of tan grossly unremarkable skin measuring 6.0 x 3.2 cm. The 1.2 x 1.0 cm nipple is everted. Surgical margin is inked. Sectioned trom lateral-to-medial aspect into eleven slices. Stice #8 contains nipple. Cut surface of slice #6 shows an ill-detined, firm pink gray tumor measuring 1.2 x 1.0 x 1.0 cm. It is 2.2 cm away from inferior margin, 2.0 cm from deep margin, 2.5 cm from the skin. Superior, Iateral and medial margins are widely free Representative sections are submitted. INK CODE: Superior - blue; interior - orange; deep - black. SECTiON CODE: A1, A2, nipple; A3, A4, slice #6, superior aspect ot tha tumor; A5, A6, slice #6 interior aspect of the tumor; A7, interior surgical margin slice #6; A8, tissue superiorly to the tumor slice #6; A9, deep surgical margin slice #6; A10, A11, tissue laterally to the tumor slice #5; A12, A13, slice #7 tissue immediately to the tumor slice #7; A14, A15, upper outer quadrant; A16, A17, lower outer quadrant; A18, A19, upper inner quadrant; A20, lower inner quadrant; A21, mid lower portion. Fragment of tumor and normal tissue are submitted to tumor bank. . (B) LEFT AXILLARY SENTINEL LYMPH NODE #1 FOR FROZEN SECTION IN VIVO 83, EX vivO 153 - Received is a single lymph node embedded into tatty tissue measuring 1.2 x 1.0 x 0.4
+
+--- Page 3 ---
+cm. Cut surtace is light tan. The section is entirely submitted tor trozen section in cassette B *FS/DX: NO TUMOR PRESENT. (C) LEFT AXILLARY SENTiNEL LYMPH NODE #2 FOR FROZEN SECTION, IN VIVO 253, EX VIVO 281 - Received is a single lymph node measuring 1.0 x 0.8 x 0.4 cm. For frozen section received is a single lymph node measuring 1.3 x 0.9 x 0.5 cm. Cut surtace is light tan. Section entirely submitted for trozen section in cassette C. *FS/DX: NO TUMOR PRESENT. (D) RIGHT BREAST, SHORT STITCH SUPERIOR, LONG STITCH LATERAL FOR IMMEDIATE CONSULTATION - Received is a 14 x 13 x 5.5 cm breast with a 6.5 x 2.5 cm ellipse of tan-skin. The 1.2 x 1.0 cm nipple is everted. Surgical margin is inked. Sectioned from the medial-to-lateral aspect into ten slices. Slice #7 contains nipple, slice #9 contains an ill-defined, infiltrating, indurated tumor measuring 1.2 x 1.3 x 1.1 cm. Radiological clip is present within the mass. The lesion is 0.7 cm from the closest lateral surgical margin, 1.5 cm from deep, 5.0 cm away trom the superior surgical margin, 4.9 cm from the inferior and 2.5 cm away from the skin. Tissue toward the medial aspect ot the breast shows dense fibrous tissue. Representative sections are submitted.d INK CODE: Superior - blue; interior - orange; deep - black. SECTiON CODE: D1, D2, nipple; D3, D4, D5, slice #9 superior aspect of the tumor; D6, D7, D8, slice #9 inferior aspect ot the tumor; D9, slice #9, tissue inferiorly to the tumor; D10 slice #9 tissue superiorly to the tumor; D11, deep margin slice #9; D12, slice #9 interior margin; D13, D14, perpendicular sections of the lateral surgical margin; D15, D16, slice #8, tissue medially to the tumor; D17, D18, upper inner quadrant; D19, D20, lower inner quadrant. (E) RIGHT SENTINEL LYMPH NODE #1 IN VlVO 130, EX VIVO 170 - Received for trozen section is a single lymph node embedded in fatty tissue measuring 2.0 x 1.0 x 0.7 cm. Cut surface is light tan. Section is entirely submitted for frozen section in cassettes E1, E2. *FS/DX: NO TUMOR PRESENT. (F) RIGHt SENTINEL LYMPH NODE #2 FOR FROZEN SECTION IN VIVO 38, EX VIVO 108 - Received a single lymph node embedded in fatty tissue measuring 2.0 x 0.9 x 0.8 cm. -Cut surface is white-tan. Section entirely submitted for frozen section in blocks F1, F2. *FS/DX: NO TUMOR PRESENT. CLINICAL HISTORY Breast cancer.. SNOMED CODes T-04050, M-85003 "Some tests reported here may have been developed and performance characteristics determined by. These tests have not been. specifically cleared or approved by the U.S. Food and Drug Administration." Released by:. Start of ADDENDUM ADDENDUM This moditied report is being issued to report the results of HER-2/neu FISH Addendum completed bv : :
+
+--- Page 4 ---
+SPECIMEN SOURCE Right breast SUMMARY Tissue section ot the invasive carcinoma :.  vas evaluated for HER-2/neu gene. amplification by interphase fluorescence in situ hybridization technique using the. HER-2/neu DNA Probe Kit (LSl HER-2/neu SpectrumOrange/CEP17 Slide adequacy is satisfactory. Sixty tumor nuclei were counted and showed an average of 1.62 copies of LS HER-2/neu gene per nucleus and an average of 1.45 copies of CEP17 per nucleus. Negative and positive controls (established by ) with this batch are. appropriate. Two representative images have been archived. INTERPRETATION The tumor cells demonstrated no ampliflcation of the HER-2/neu gene copy levels (HER-2/neu: CEP17 signal ratio: 1.11 ) The following guideline has been established for HER-2/neu testing:. Normal HER-2/neu levels: < 1.80; equivocal HER-2/neu levels: 1.80 -- 2.20; amplified HER-2/neu levels: > 2.20 (Ret: Arch Patholo Lab Med. 2007; 131:18-43) NOTES The LSl HER-2/neu probe is specitic tor the HER-2/neu gene Locus (17q 11.2-q12) and the CEP 17 DNA probe is specific for the alpha satelite DNA sequence at the centromeric region ot Chromosome 17 (17 p11.1 -q11.2). This test has been cleared and approved for specitic uses by the U.S. Food and Drug Administration. Its system is operating within the performance specitications stated in the product insert. Released by: --END OF REPORT--
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diff --git a/output/text/43b2f4c1-d618-4eaf-a9fd-b62602615b84.txt b/output/text/43b2f4c1-d618-4eaf-a9fd-b62602615b84.txt
new file mode 100644
index 0000000000000000000000000000000000000000..abe1f27cf095f21db2284c8ac2d7e3b8295bc675
--- /dev/null
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+--- Page 1 ---
+UUID:0E9A48BA-AAE0-4D88-90E1-141483700759 TCGA-NH-A8F7-06A-PR Redacteds  RUN DATE : PAGE 1 RUN TIME:  RUN USER: Lab Database: PATIENT: ACCT #: LOC: AGE/SX : F ROOM: REG DR: DOB: BED: STATUS : SPEC #: RECD: STATUS: PERFORMED AT  COLL : TIME IN FORMALIN: hrs COLD ISCHEMA TIME: mins. CLINICAL INFORMATION: Pre-Op Diagnosis: Remarks: Specimen(s) : A. Subtotal colectomy with left tube and ovary. B. Right tube and ovary FD03 Calt : Drgrntud eslors Gi5.7 MICROSCOPIC DIAGNOSIS Q 4/kj14 A COLON. TERMINAL ILEUM. APPENDIX AND OMENTUM (SUBTOTAL COLECTOMY): TUMOR #1 MODERATELY DIFFERENTIATED ADENOCARCINOMA OF CECUM TUMOR INVADES THROUGH THE BOWEL WALL METASTATIC CARCINOMA IN 8 OF 23 REGIONAL LYMPH NODES METASTATIC CARCINOMA TO OMENTUM MARGINS APPEAR UNINVOLVED WITH CLOSEST MARGIN RADIAL. <1 CM TO METASTATIC CARCINOMA TUMOR #2 MODERATELY DIFFERENTIATED ADENOCARCINOMA. SIGMOID COLON TUMOR INVADES FOCALLY THROUGH THE BOWEL WALL iel&kl NO METASTASIS IN 18 REGIONAL LYMPH NODES MARGINS APPEAR UNINVOLVED WITH CLOSEST MARGIN DISTAL AT 5 CM FROM TUMOR LEFT FALLOPIAN TUBE AND OVARY (SALPINGO-OPHORECTOMY) ; METASTATIC ADENOCARCINOMA TO OVARY B. RIGHT FALLOPIAN TUBE AND OVARY (SALPINGO-OOPHORECTOMY) :  METASTATIC ADENOCARCINOMA TO FIMBRIATED END OF FALLOPIAN TUBE COMMENT(S) The subtotal colectomy contained two separate but histolcgically indistinguishable. moderately di fferentiated adenocarcinomas. Tumor #1 was located in the cecum and appeared. more advanced with numerous metastasis to regional lymph nodes. Tumor #2 was located in the sigmoid colon without regional lymph node metastasis. In completing the synoptic reports below. I judged the metastatic tumor to be associated with the more advanced cecal adenocarcinoma. ** CCNTINUED ON NEXT PAGE **
+
+--- Page 2 ---
+RUN DATE: PAGE 2 RUN TIME: Specimen Inquiry RUN USER: Lab Database: SPEC # #- PATIENT: (Continued) COmment(S) (Continued) SURGICAL PATHOLOGY CANCER CASE SUMMARY (CECAL TUMOR) - CAP APPROVED Specimen: Terminal ileum. cecum. appendix. ascending colon. transverse colon. descending colon. sigmoid colon.. bilateral ovaries and fallopian tubes. omentum Procedures: Subtotal colectomy with BSO CECAL TUMOR:. Tumor Site: Cecum 4.5 cm in greatest dimensions Tumor Size: Macroscopic Tumor Perforation: Not identified Histologic Type: Adenocarcinoma Histologic Grade: Low-grade Microscopic Tumor Extension: Tumor invades through the muscularis propria into the subserosal adipose tissue or the nonperitonealized. pericolic or perirectal soft tissues but does not extend to the serosal surface Proximal. distal and radial margins appear uninvolved Margins: with metastatic tumor within 1 cm of radial margin at ileocecal junction Treatment Effect: No prior treatment Lymph-Vascular Invasion Present Not identified Perineural Invasion: Tumor Deposits: Present Pathologic Staging: Primary Tumor' pT3 Regional Lymph Nodes: pN2b Number examined: 23 Number involved: 8 Distant Metastasis:  pMib - metastasis to left ovary. right fallopian tube and omentum SIGMOID TUMOR Sigmoid colon Tumor Site: 5.5 cm in greatest dimensions Tumor Size: Macroscopic Tumor Perforation: Not identified Histologic Type: Adenocarcinoma Histologic Grade: Low-grade Tumor invades through the muscularis propria into the Microscopic Tumor Extension subserosal adipose tissue or the nonperitonealized pericolic or perirectal soft tissues but does not extend to the serosal surface Margins Proximal. distal and radial margins appear uninvolved with metastatic tumor within 5 cm from distal margin Treatment Effect No prior treatment Not identified Lymph-Vascular Invasion: Perineural Invasion: Not identified Tumor Deposits Not identified Pathologic Staging: Primary Tumor: pT3 ** CONTINUED ON NEXT PAGE **
+
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+RUN DATE PAGE 3 RUN TIME : Specimen Inquiry RUN USER: Lab Database: SPEC #:- PATIENT : (Continued) comment(s) (Continued) Regional Lymph Nodes: pNO Number examined: 18 Number involved: 0 Distant Metastasis: not applicable GROSS DESCRIPTION: Specimen A is received in the fresh state labeled "subtotal colectomy with left tube and Ovary". The specimen consists of the following: 15 cm of terminal ileum measuring 2 cm in diameter Vermiform appendix measuring 5 cm in length by 0.7 cm in diameter 65 cm of large intestine measuring approximately 5 cm in diameter. Attached omentum measuring 20 x 14 by up to 2 cm in thickness An ovary and fallopian tube attached in the area of the sigmoid colon Mesentery measuring up to 9 cm in radial dimension at the ileocecal junction and. up to 9 cm in radial dimension at the sigmoid colon Adhesions are noted at the ileocecal junction and between the ovary and sgmoid colon. There are firm tumorous nodules in the mesentery at the ileocecal junction and in the omentum. The omental tumor nodule measures 2 cm in greatest dimension. There are multiple mesenteric nodules at the ileocecal junction measuring up to 1.5 cm in greatest dimension. The bowel is opened to reveal a circumferential fungating tumor in the cecum approximately 2 cm from the ileocacal valve. This tumor measures 4 5 cm along the length of the bowel The bowel is narrowed in this area. A second circumferential fungating mucosal tumor is identified 5 cm above the distal margin.  This second tumor measures 5.5 cm along the length of the bowel and again the bowel appears narrowed in this area. The attached ovary appears enlarged. measuring 5 x 4.5 x 3 cm. It has a smooth tan surface. Its cut surface reveals soft tan tumorous tissue replacing 9o% of the ovary. The fallopian tube with fimbriated end measures 4.5 cm in length by 0.5 cm in diameter.. The initial gross features in the O.R. at. The specimen is allowed to are reported to Dr. fix overnight prior to secrioning. Representatsv. sections are submitted as follows: A1 terminal ileum A2 vermiform appendix A3-6 - cecal tumor A7-12- lymph nodes in mesentery regional to cecal tumor A13 apex of ileocecal iesentery A14 omental tumor nodule A15.16- left ovary and tube. A17-20- distal tumor A21 distal margin A22-25- lymph nodes and mesentery regional to distal tumor NOTE :  The tumors invade the full thickness of the bowel wall. likely extending through the. bowel wall Specimen B is received in formalin labeled "right tube and ovary" This is an ovary with ** CONTINUED ON NEXT PAGE **
+
+--- Page 4 ---
+PAGE 4 RUN DATE: RUN TIME: Specimen Inquiry RUN USER: Lab Database: SPEC #: PATIENT : (Continued) GROSS DESCRIPTION: (Continued) attached fallopian tube.  The tube with fimbriated end measures 4.5 cm in length by 0.5 cm in diameter. The ovary measures 3.5 x 1.2 x 1 cm. It has a normal appearing wrinkled tan surface. The tube is unremarkable. The ovary has a solid tan to white cut surface without obvious tumor. Representative sections are submitted in cassettes Bl and B2. INTRAOPERATIVE CONSULTATION: SUBTOTAL COLECTOMY. GROSS EXAM: TWO SEPARATE COLON CANCERS IDENTIFIED. ONE IN THE CECUM AND THE OTHER 5 CM ABOVE THE DISTAL MARGIN MARGINS APPEAR UNINVOLVED FINDINGS REPORTED TO DR. IN THE O.R. AT TUMOR HARVESTED FOR TISSUE BANKING PHOTO DOCUMENTATION Image Signed (signature on file) ** END OF REPORT **
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+IDENTIFIED CALCIFICATIONS ARE PRESENT IN THE IN SITU C MEASURING 5) SECTIONS AND CYTOKERATIN IMMUNCHISTOCHEMICAL STAINS (1/1). NO INVOLVEMENT OF THE NIPPLE BY EITHER IN SITO CELLS) 2) CYTOKERATIN (aE1:AE3) SHOW NO sVIDeNCE OF METASTATIC CARCINOMA. - ADDITIONAL DIAGNOSIS: 5: Specimens Submitted: breast. Presents for TM, sentinel Clinical Diagnosis & History:  LYMPH NODE. SENTINEL #2 LEVEL I RIGHT AXILLA; BIOPSY: SP BREAST. RTGHT! TOTAL MASTECTOMY: LYNPH NODE, LYMPH NODE, SENTINEL #1 LEVEL I RIGHT AXILLA; BIOPSY: LYMPH NODE, ASTATIC with approximately 2.6 cm invasive lobular carcinoma of right *+ Continued on next page *+ <2MM  STAINED SECTIONS AND IMMUNOH STOCHEMICAL STAINS FOR IN SITU (LCIS) IS ALSO   NON-SENTINEL #1 RIGHT AXILLA: BIOPSY: LYMPI #2, 1cs-0-3 NOTED IN THE TAST right PLEOMORPHIC TYPE (E-CADHERIN NEGATIVE) axilla .lymph node biopsy. right CARCINOMA. IDENTIFIED, PLEOMORPHIC TYPE.I MECROSCOPIC axilla  INVASIVE CARCINOMA IS  ON H&E STAINEDS CLUSTERS )\R\25 dw 1o/2(n 8022|3 UUID:6CE21603-4200-408A-94AA-15F24EE4AC7F Redacted
+
+--- Page 2 ---
+- NO INVOLVEMENT OF THE SURGICAL MARGINS BY EITHER INVASIVE OR IN SITU CARCINOMA IS IDENTIFIED. 1 - NO SKIN INVOLVEMENT BY CARCINOMA IS IDENTIFIED. - THE SKIN SHOWS SEBORRHEIC KERATOSIS.S - THE NON-NEOPLASTIC BREAST TISSUE SHOWS FIBROCYSTIC CHANGES. .THE LYMPH NODE STATUS IS AS FOLLOWS (EXPRESSED AS THE NUMBER OF POSITIVE LYMPH NODES IN RELATION TO THE TOTAL NUMBER OF LYMPH NODES EXAMINED) : LEVEL I: 0/3. - ER: 1OOt NUCLEAR STAINING WITH STRONG INTENSITY PR: 3OT NUCLEAR STAINING WITH WEAK TO MODERATE INTENSITY HER2/NEU (HERCEPTEST): POSITIVE (STAINING INTENSITY OF 2+) I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED JPON MY PERSONAL EXAMINATION OP THE SLIDES (AND/OR OTHER MATERIAL). AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. .. Report Electroaically Signed Out *w. Special Studies: Result Special Stain Conment AE1:AE3 NEG CONT IMM RECUT AE1:AE3 AEL: AE3 NEG CONT IMM RECUT AE1:AE3 NEG CONT IMM RECUT sr-c PR-C HER2-C E-CADHERIN NEG CONT NEG-HER2 IMM RECUT Gross Description: 1). The specimen is received fresh for frosen section consultation, labeled "Sentinel nods #1, level 1. right axilla' and consists of a lymph node measuring 0.4 x 0.3 x 0.3 cm.. frozan section diagnosis.  The lymph node is bisected and submitted for. Summary sections: Fsc - frosen section control *+ Continued on next page
+
+--- Page 3 ---
+2).  The specimen is received fresh for Erozen section consultation labeled. "Sentinel node #2. level 1, right axilla" and consists of a lymph node measurirg 0.5 x 0.5 x 0.4 cm. frozen section diagnosis.  The lymph node is bisected and submitted for Surnary sections: Fsc - frozen section control 3).The specimen is received in formalin, labeled *non-sentinel node number One right axilla" and consists of one single pink-tan firm lymph node measuring 0.3 x 0.3 x 0.2 cm. Entirely submitted in one cassette. Summary of sections: CN-- lymph rodes 4).The specimen is received in formalin, Iabclcd *sentinel node #3 level 1 right axilla" and consists of one single lymph node measuring 0.5 x 0.4 x 0.3 cm. The lymph node is entirely submitted.. Summary of sections: LN- lymph node 5)The specimen is raceived fresh. labeled -right breast, stitch marks axillary tissue level 1n and consists of a breast with attached axillary tail. The breast measures 15.2 x 20.3 x 3.1 cm with overlying skin ellipse measuring 14.1 x 6.0 x 8.0 cm. nipple measuring 2.8 x 0.8 x 0.2 cm and areola measuring 2.8 x 2.7 cm.  Situated on the skin surface is an everted. Skin shows no grossly visible scars. superior-lateral to the nipple measuring 1.7 cm in diameter. A suture  There is a brown plaque-like lesion demarcates the axillary tail which measures 8.5 x 3.3 x 0.5 cm. posterior surface of the breast is inked black and the specimen is serially sectioned to reveal an ovoid white-tan tumor located in the upper outer The quadrant 2.5 x 1.6 x 1.3 cm, located 1.3 from the deep margin. remainiag breast tissuo shows yellow lobulated adipose tissue admixed with white fibrous soft cissue with no other grossly identifiable losions. The axillary tissue is dissected to reveal several possible lymph nodes, ranging in sise from 0.3 cm to 0.9 cm. The Specimen and all identified axillary lymph nodes are submitted. Reprosentative sections of the mastectomy. submitted for tps. Tissue Summary of  soctions:  - nipple NB - nipple base S - skin lesion - deep margin tumor UIQ  - upper inner guadrant Continuad on next page
+
+--- Page 4 ---
+LIQ - lower inner quadrant UoQ - upper outer quadrant LOQ - lower outer quadrant LNS -- individual level 1 lymph nodes Sunmary of Sections: Part 1:  SP: Sentinel node #l, level one, right axilla. Block Sect. site 1 PCs Fsc 1 Part 2: SP: Sencinel node #2. level one, right axilla. Block Sect. Site PCs 1 fsc 1 part 3: SPNor sentinel node #1 right axilla Block Sect. site pCs 1 In 1 Part 4: SP: Sentinel node #3 level 1 right axilla. Block Sect. Site PCs 1 1n 1 Part 5: SP: Right breast. Block Sect. Site H 2 PCs D LIQ LNS 23 L0Q 1 N 2 1 11222 NB 1 1 1 UrQ 2 UOQ Intraoperative Consultation: Note: tissue sample examined at the time of the iatraoperative consultation. 1) FROZEN SECTION DIAGNOSIS:  PERMANENT DIAGNOSIS: BENIGN. SAME Continued on next page *
+
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+FROZEN SECTION DIAGNOSIS: BENIGN. Page s of PERMANENT DIAGNOSIS:S (RAS) SAME End of Repor
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+UUID:C42864D6-13D0-4492-B502-88642E0583A90 TCGA-LN-A4MQ-01A-PR Redacted Clinical Case Report (For Collection of Cancerous Tissue). Ics-0 - 3 Site> 1srphagu, 1owrw C15.5 Informed Consent I personally informed this patient that a specimen(s) would be collected to be used for research purposes.I reviewed the. RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the. consent form as a free and voluntary act. A copy of this informed consent document will be retained at. our institution. Name of Physician or Study Coordinator. Clinical Information TMSGENERALINEORMATIONN Date of Birth (mm/dd/yyyy) Height Marital Statusd Race Temperatured Lm 68  Single Married VEELASS$ Gender Weight  Divorced  Widow Blood Pressure Heart Rate Male  Female 5.6 k0 12/8 0 AEEHHISTORYOEPRESENTILLNESSAASTAM Chief CompIaints: Trouhle3Walluwi`ncy j fever Symptoms: Weight Coss. Clinical Findings: Performance Scale (Karnofsky Score):  100 Asymptomatic   80-90 Symptomatic but Fully Ambulatory   60-70 Symptomatic, in bed iess than 50% of day  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden  20-30 Bed Ridden PAPACURRENTMEDICATONSNSAAC Date (mm/dd/yyyy) Drug Dose Route Frequency To To To To To
+
+--- Page 2 ---
+.ACNUPASTMEDICAL.HISTORYS.. Status Diagnosis Date Treatment Diagnosis/Disease/Disorder/Injury HOBGYNHSTORYR # of Pregnanciesd Date of First Menses Menopausal Status  Pre-menopausal # of Live Births Date of Last Menses  Peri-Menopausal  Post-menopausal  Hormone Replacement Birth Control:  Condom  Oral Contraceptive lUD Therapy:  Other: OSRSOCIALHISTORYNSR Environmental Hazards: Occupation: Smoking History Duration When Quit TYPE Packs/day Current Status (yrs) (yr)  YES nO Alcohol Consumption  Duration When Quit TYPE Drinks/day Current Status (yrs) (yr)  yes  DANO Drug Use  Duration When Quit TYPE  Frequency Current Status (yr) (yrs)  YES ANO MASMOTSRFAMILYMEDICADHISTORYHA CANEO Age of Diagnosis  Diagnosis  Relative Date  Result Date Test Test Result CEA  Negative  Positive: p Negative  Positive: HIV F CA 15-3  Negative  Positive:  Negative   Positive:  Hep B   Negative  Positive: CA 19-9  Negative  Positive: Hep C  PSA  Negative  Positive:  Negative  Positive: AFP Other:  Negative  Positive: Other:  Negative  Positive:  B/T Cell Markers: 2
+
+--- Page 3 ---
+HAS SGSASUDIAGNOSTIC STUDIESERATMXS Study Results Date Ultrasound X-Ray CT Endoscopy  MRI Biopsy x CeRci nuni) HORSAAECLINICALDIAGNOSISNAR Preoperative Clinical Diagnosis Location of Suspected Distant Metastasis Location of Suspected Involved Lymph Nodes Clinical Staging Date of Diagnosis T3 N1 MD Stage: Treatment Information FSEPNESURGICALTREATMENTWRAM Date of Procedure Procedure Posectian th Lowes pant ?f oe apha gsay Primary Tumor Detailed Location Size  Organ loweR Z xhsx1 cm Oeso png gys Extension of Tumor Lymph Nodes Location of Lymph Nodes # of Lymph Nodes Description  Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Size Organ Detailed Location Surgical Staging 3NAM2 Stage: 117 T NEOADJUVENTTHERAPY ChemoRadiation Immumo Hormonalor Molecular Date (mm/dd/yyyy)  Dose Route Frequency Drug/Treatment / To To 1 / 1 1 To / To To 1 3
+
+--- Page 4 ---
+Pathology Form Specimen Information .Date: Collected by:  Date: Preserved by: wSPECIMENTYPE(#of samplesprovideds  Slide Paraffin Block  Blood/Serum/Plasma Frozen Diseased  Normal Normal  Diseased  Normal Diseased Normal Diseased 4 2 2. /4 2 Time to Formalin Time to LN2  Time to LN2 min  / 3 min 12. min SCSMRANZAAASPATHOLOGICALDESCRIPTIONEAC Primary Tumor Extension of Tumor Distance to NAT Size Organ lewes: 6 cm 2 x%x/ cm Cesopiazus VermiR Lymph Nodes # Metastasized # Examined Location Distant Metastasis Size Detailed Location Organ Pathological Staging m o Stage: pT 3 N1 Notes: noelg ( M,,Mz ) in Neitre q0t
+
+--- Page 5 ---
+Microscopic Description swwkwHistologicalPatternatwea Cell Distribution +. Structural Pattern + Diffuse p  Streaming  Storiform  Mosaic Necrosis Fibrosis Lymphocytic Infiltration  Palisading  Vascular Invasion Cystic Degeneration Clusterized Bleeding  Alveolar Formation  Myxoid Change  Indian File  Psammoma/Calcification CeularDiffrentation Adenomatous + Sarcomatous + Lymphomatous+ - Squamous +  Squamoid Cell  Glandular cell Round Cell Large Cell Spindle Cell Cell Stratification Fibroblast Small Cell  Keratin Osteoblast  RS Cell/RS Like Secretion  Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell Gland formation  Myoblast  Plasma Cel! Pearl Well Moderate   Poor Cellular Differentiation: w.ularAppearance  0 1 II III Nuclear Atypia: Aniso Nucleosis  Hyperchromatism  Nucleolar Prominent Y  Multinucleated Giant Cell Mitotic Activity. Nuclear Grade: Value Date Marker Result ER Negative  Positive PR Negative Positive Her-2/neu  Negative  Positive B-Cell Marker  Negative  Positive T-Cell Marker  Negative   Positive Other:  Negative  Positive Other: Negative  Positive Final Pathology Report cell caecinume A l/e cesesliegxe Souamoes Histological Diagnosis: Grade:IZ I pspolesa le lig --eisgerasticdee) Comments: Date  Pathologist 5
+
+--- Page 6 ---
+COnsOLIdateD DIAgnOstIc pathOLOgy fOrm* Microscopic Appearance. Histological pattern: CELL DISTRIBUTION + STRUCTURAL PATTERN Diffuse  Streaming:  Mosaic Storiform Necrosis x  Fibrosis  Lymphocytic Infiltration X Palisading Vascular Invasion XI Cystic Degeneration Clusterized Bleeding Alveolar Formation X Myxoid Change Indian File ].Psanmoma/Calcification 2. Cellular features: Squamous - Adenomatous  Sarcomatous + Lymphomatous  Squamoid Cell Glandular cel! Round Cell Large Cell Spindle Cell Cell Stratification  Fibroblast Small Cell Secretion Osteoblast RS CeIl/RS Like  Keratin Intracyt. Vacuole  Lipoblast Inflam. Cell  Desmosome X Myoblast  Plasma Cell  Pearl Gland formation Otherwise Specified: D,70!s DyGOZ D2 0L GOZ Neogos 2.Cellular Differentiation: Well Moderately 3.Nuclear Atypia: Nuckar Appearanced  Aniso Nucleosis Hyperchromatism  Nucleolar Prominent Multinucleated Giant Celle Mitotic Activity Nuclear Grade G 3 Histological Diagnosis:_&gl& m t?ss Cell Cg Ren Aog Date PATHOLOGIST STAFF FOR RESEARCH USE ONLY *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR ANDS Criteria Diagnusis Discre HPAA Discrepancy Case is(airc
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+1cs-0-3 adincacinome,Nos 8146f3 Sh :.Digmn'd (pw CQcF) c18.7 jw 3|38|11 Sample ID #: Diagnosis: 1.: Colon resectate under inclusion of a moderately differentiated adenocarcinoma of the colorectal type and of a max. size of 3 cm, with infiltration of the pericolic fatty tissue and seven regional lymph node metastases, one of which is located in the mesenteric resection margin. Tumor-free small and large intestinal resection margins. 2.: Ileocolon resectate under inclusion of a moderately differentiated adenocarcinoma of the colorectal type, formed at the base of a tubular adenoma with high-grade dysplasia and located in the cecum, with infiltration of the tunica submucosa. Tumor-free regional lymph nodes. Tumor-free small and large intestinal resection margins. Tumor-free mesenteric resection margin. Tumor-free appendix. Tumor-free omental fat tissue. Tumor stage for I.: pT3 pN2 (7/25) pMX; G2 L1 V0, locally R0 Tumor stage for 2.: pT1 pN0 (0/26) pMX; G2, L0, V0, R0 Redacted UUID: S5E026EA-CC8D-4295-896D-0FFDACE323B0
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diff --git a/output/text/43f8dc74-d1fe-4726-a645-59143be3117a.txt b/output/text/43f8dc74-d1fe-4726-a645-59143be3117a.txt
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index 0000000000000000000000000000000000000000..1c05104a633df2da599e5663f1c1be9e02f90feb
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+TD-03 Mxlsnmi Rjunli ciIlNE Date of surgery : $77213 491.3 Left eye enucleation Macroscopy The eyeball measures 25 by 25 by 25 mm with a posterior segment of optic nerve of 8 mm. At the section of the eyeball there is a tumor of 12 by 10 mm. Samples have been made for cryopreservation and genomic profiling and the specimen has been then included entirely. after fixation. Microscopy The tumor seen macroscopically correspond to a choroidal melanoma. The tumor cells are mostly non pigmented and fusiform. They are organized in crisscrossing bundles. There are atypical ovoid nuclei which show few mitotic figures with 1 mitosis by 10 fields at the 400 magnification. The tumor is distant from the emergence of the optic. nerve and distant from the ciliary processes. However it infiltrates the whole thickness of the. sclera with extra sclera extension visible (specimen D and E). There are tumor cells around the extra scleral vessels without visible neoplastic embolus in the lymphatic channels. Conclusion UUID:C0F9EB5A-8CBD-4BDB-A67C-B205AC198A42 A9EH-01A-PR Redacted Choroidal melanoma of the left eye Predominant cell type fusiform Size of the tumor: 12mm Mitotic index is low Whole sclera infiltration with extrasclerale extension The optic nerve on its entire course as well as the meningeal sheaths are free
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diff --git a/output/text/441f9ca8-9b59-45b0-8feb-1ec67aabb785.txt b/output/text/441f9ca8-9b59-45b0-8feb-1ec67aabb785.txt
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+UUID:ED6B8969-93D9-4198-BE44-1538CE556F60 TCGA-4A-A93X-01A-PR Redacted ABNORMAL SURGICAL PATHOLOgy REPORT Patient: Result ID: Accession: DOB: Age Sex: M Account: Date Collected: MRN:  Date Received: Requested by: Patient Date Reported: Copy to: Clinical Data: Right kidney mass, biliary colic FINAL pathologic Diagnosis 1. Right kidney, radical nephrectomy:  Papillary renal cell carcinoma, see Synoptic Report. 2. Lymph nodes, pericaval, lymph node diss ection: Two lymph nodes positive for metastatic papillary renal cell carcinoma (2/2).. Largest metastatic deposit measures 2.2 cm in greatest dimension. Extracapsular extension: Present. See Comment. Comment:  Tumor extends to the inked surgical margin ot the largest invoived lymph node ICD-O3 3. Gatlbladder, cholecystectomy: Chronic calculous cholecystitis.. 8&bo|3 Negative for malignancy. Sit B>YselueyNt5 064.9 SYNOPTIC REPORT MO3/24114 Procedure: Radical nephrectomy. Specimen laterality:. Right Tumor site: Superior pole Tumor size: 8.5 cm in greatest dimension Tumor focality: Unifocal Macroscopic extent of tumor:. Tumor extends into perinephric fat and into renal vein, renal artery, and ureter within. the renal pelvis Histologic type:  Papillary renal cell carcinoma Sarcomatoid features: Not identified Tumor necrosis: Present Histologic gra de: Fuhrman nuclear grade G3 Microscopic tumor extension:. Tumor extends into the perinephric fat beyond the renal capsule, into the renal pelvis, renal vein, renal artery, and pelvic portion of ureter Page 1 of 3
+
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+SUrgICAL PAtHOLOGy REPOrt - COnTInUeD Patient:  Result ID Accession:  Margins: Margins of main specimen uninvolved by invasive carcinoma (see Comment).. Renal parenchymal margin: Negative Perinephric fat margin: Negative Gerota's fascial margin:  Negative Renal vein margin:  Negative Renal artery margin: Negative Ureteral margin Negative Lymphovascular invasion: Present Additional findings: Adrenal gland: Uninvolved Pathoiogic Tumor Stage: pT3a pN1 Comment: While the margins of the main specimen are uninvolved, tumor is seen at the inked surgical margins  surrounding the larger of the pericaval lymph nodes (specimen #2). The tumor is composed of papillary structures with. fibrovascular cores, which are lined by tumor cells with amphophilic cytoplasm and large, slightly irregular nuclei with prominent eosinophilic nucleoli.. Pathologist, Electronic Signature. Intradepartmental consultation: Specimen(s) SuBmItteD: GrOss DescriptiOn 1. Right kidney mass: In formalin labeled *right kidney mass" is a 15 x 7.5 x 6.5 cm kidney with abundant attached perinephric fat weight 1,721 grams in aggregate. There is 3.5 cm ureter extending from the renal hilum. The kidney is bivalved to reveal an ill defined 8.5 cm in greatest dimension variegated tan-white to red nodular tumor within the. superior pole. On cut section, the tumor grossly appears to possibly extend into the perinephric fat at the superior pole. The tining of the renal pelvis is grey-white and slightly bosselated. Upon sectioning it appears that the tumor elevates the urothelium and it is unclear at gross dissection whether the tumor penetrates through the urothelium into the renal peivis. The tumor also grossly extends into the renal artery, lying 5mm from the renal artery resection margin. The remaining renal parenchyma is pale tan-pink with an ill defined corticomedullary junction. There is a small portion of adrenal gland at the most superior aspect of the specimen with an orange red cut surface. The gland grossly does not appear to be involved by tumor. The perinephric fat is inked black. Representative sections are submitted in eight cassettes as labeled: A vascular and ureter margins, B tumor to include perinephric fat, C-D tumor to include renal pelvis, E tumor to include renal artery, F tumor to include uninvolved renal parenchyma, G normal renal parenchyma, H adrenal gland. 2. Peri-caval node: In formalin labeled "peri-caval node" are two nodular tan-pink tissues which measure 3.5 x 3 x 2.3 cm and 2.5 x 1.5 x 0.8 cm. The larger tissue is inked blue and the smaller tissue is inked black. Sectioning of the larger tissue reveais a slightly friable and partially cystic tan-pink cut surface containing coagulated blood. Sectioning of the smaller tissue reveals a partially cystic red-brown cut surface containing coagulated blood. Representative sections are submited in 4 cassettes as follows: A-B entire smaller tissue, C-D larger tissue.. 3. Gallbladder: in formalin labeled "gallbladder" is a 9.5 x 5 x 2.8 cm intact gallbladder. The serosa is tan-pink and dull. The cystic duct is 0.3 cm in diameter and patent. The gallbtadder wall averages 0.2 cm in thickness. The mucosa is velvety yellow-red with diffuse yellow stippling within the body. The lumen contains tan-yellow viscous bile and a 2.5 cm green-black granular cholelith. Representative sections to.include the cystic duct margin (inked black) are submitted in One cassette. ICD-9 CODe(S): Cpt CODE(S): FACILITy: Page 2 of 3
+
+--- Page 3 ---
+SURGICAL PATHOLOgy REPORt - CONTiNUED Patient:  Result ID: Accession:  88307 x2, 88304 1990 bJ 13f3|13 END OF REPORT
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+UUID:B7384883-1B7A-4EE2-A874-2CD82F1988A3 TCGA-2K-A9WE-01A-PR Redacted PATHOLOGY EXAMINATION PATIENT NAME COLLECTED: MED. REC. #: CLIENT: SOC. SEC. #: PHYSICIAN: GENDER: ADDITIONAL: NO ADDITIONAL PHYSICIANS ACCOUNT #: COPY TO/NOTES: Page 1 df 2 SPECIMEN(S) RECEIVED: A: Left kidney & ureter. CLINICAL DATA/HISTORY: Left kidney renal cell cancer. FINAL PATHOLOGIC DIAGNOSIS: Left Kidney And ureter: PAPILLARY RENAL CELL CARCiNOMA, TYPE II, NUCLEAR GRADE 3. SYNOPTIC REPORT: tcD o-3  PROCEDURE: RADICAL NEPHRECTOMY. SPECIMEN LATERALITY: LEFT. 8260/3 Tumor site: mid to inferior pole. Tumor size: 15 cm. TUMOR FOCALITY: UNIFOCAL. MAcROSCOPIC EXTenT Of TumOR: LimITeD TO KIDNey. HISTOLOGIC TYPE: PAPILLARY RENAL CELL CARCINOMA. 117714 SARCOMATOID FEATURES:NOTIDENTIFIED. TUmOR NECROSIS: PRESENT.. HistologIC Grade: G3. MICrOSCOPiC TumOR EXTensION: TumOR APpEArs LimITed TO KIDney, SEE COmmenT. MARGINS: MARGINS APPEAR UNINVOLVED BY INVASIVE CARCINOMA, SEE COMMENT.S LYMPH-VASCULAR INVASION: PRESENT. PATHOLOGIC STAGING: pT2b pNX. COMMENT: The features are of a type ll papillary renal cell carcinoma. Upon receipt of the specimen, there is capsular. disruption about the lower pole of the specimen with axposed necrotic tumor present at surface. Histologic sections do not reveal capsular invasion, and this gros. finding histologically appears to be iatrogenic. Correlation with the clinical findings is needed. Consultant: ***ELECTRONICALLY SIGNED OUT*** GROSS DESCRIPTION: Leit kidney & ureter: Received fresh labeled -. left kidney and ureter" and consists of a 1151 gram. nephrectomy specinen measuring 25 x 15 x 9 cm induding kidney measuring 22 x 12 x 6 cm and perirenal fat ranging in thickness from 1 to 6 cm. Extending from the renal pelvis is a ureter (6 x 0.5 cm), renal artery measuring 7x 0.5 cm, and renal.vein measuring 0.5 x 1 cm. The renal vein is free of gross abnormality at the margin. The specimen is received with a surface disruption at the inferior pole and at the lateral aspect of the kidney measuring 6 cm in greatest dimension through which friable necrotic debris extrudes. The adjacent fat is marked with black ink. In the mid lower pole and corresponding to the capsular disruption is a well circumscribed predominantly necrotic mass measuring 15 x 10 x 9 cm. The mass lies 1 cm from the renal vein margin and grossly extends through the renal
+
+--- Page 2 ---
+Page 2 of 2 capsule and perirenal fat at the capsular disruption site. The remainder of the renal cortex is tan-brown with a well. defined corticomedullary junction. The pelvis and calyces are covered by smooth glistening mucosa. The adipose. tissue is thinly sectioned, and no lymph nodes are found. The case is reviewed by..  Representative sections of the specimen are submitted as follows:  A1) renal vein, artery and ureter margins en face; A2-3) capsular disruption two fragments per cassette; A4-8) capsule wall, two fragments per cassette; A9) non-neoplastic kidney:. A10) perinephritic fat. At the request ofa  the specimen is regrossed with additional sections of the perihilar blood vessels. submitted in cassettes A11-A15 under the direction of. MICROSCOPIC DESCRIPTION: Sections of vascular and ureteral margin tissues do not show a neoplasm. Sections of the grossly described lesion show a necrotic papillary carcinoma with patchy hemosiderin, and areas of variably foamy cytoplasm. Nuclear characteristics show areas of prominent nucleoli and irregular nuclear borders. There is assoclated organizing blood. Small vessel vascular space invasion is present. Tumor does not appear to involve renal pelvis or hilar tissues.. Sarcomatoid areas are not seen in the examined sections. .
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diff --git a/output/text/443c1013-c352-4909-8bbd-f4ca3b643d5b.txt b/output/text/443c1013-c352-4909-8bbd-f4ca3b643d5b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2305794441b97cf1aa143e9216781aa7bfcc797b
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+Pathology Report DIAGNOSIS (A) PORTION OF 11TH RIB: Segment of rib for gross inspection only. (B) LEFT PARTIAL KIDNEY MID ASPECT: CHROMOPHOBE RENAL CELL CARCINOMA, EOSINOPHILIC TYPE, FUHRMAN'S NUCLEAR GRADE 3 (SEE COMMENT) TUMOR FOCALLY EXTENDS INTO PERINEPHRIC ADIPOSE TISSUE TUMOR MEASURES 4.5 CM IN MAXIMUM DIMENSION. Parenchymal and soft tissue margins of resection free of tumor.. (C) LEFT PARTIAL KIDNEY MID ASPECT, INFERIOR MARGIN:  Renal parenchyma, no tumor present. (D) LEFT PARTIAL KIDNEY, MID ASPECT, INFERIOR/LATERAL: Renal parenchyma, no tumor present. (E) LEFT PARTIAL KIDNEY MID ASPECT, LATERAL MARGIN: Renal parenchyma, no tumor present. (F) LEFT PARTIAL KIDNEY, MID ASPECT, SUPERIOR MARGIN: Renal parenchyma, no tumor present. (G) LEFT PARTIAL KIDNEY, MID ASPECT, SUPERIOR/LATERAL: Renal parenchyma, no tumor present. (H) LEFT PARTIAL KIDNEY, MID ASPECT, DEEP/MEDIAL:  Renal parenchyma, no tumor present. (I) LEFT PARTIAL KIDNEY, DEEP/LATERAL:  Renal parenchyma, no tumor present. (J) LEFT ADRENAL GLAND: Adrenal gland, no tumor present. (K) LEFT PERIAORTIC LYMPH NODES: Seven lymph nodes, no tumor present. COMMENT The tumor is composed predominantly of cells with eosinophilic, granular cytoplasm and perinuclear halos. The immunohistochemical stains demonstrate that the tumor is strongly and diffusely positive for ctyokeratin 7 and negative for vimentin. CD10 stain demonstrates predominantly cytoplasmic and focally membranous staining. The electron microscopic examination demonstrates the presence of large number of intracytoplasmic vesicles with few occasional mitochondria with tubular cristae. The immunohistochemical profile and the electron microscopic findings are consistent with chromophobe renal cell carcinoma. GROSS DESCRIPTION (A) PORTION OF 11TH RIB - The specimen consists of an 8.1 x 1.4 x 0.5 cm tan portion of rib with overlying shaggy dark red cauterized skeletal muscle. The specimen is for gross inspection only.. (B) LEFT PARTIAL KIDNEY, MID ASPECT - A 9.0 x 7.0 x 3.5 cm partial nephrectomy specimen. There is a tumor (4.5 x 4.2 x 4.0 cm) with yellow-brown/mahogany, lobulated surface with focal areas of hemorrhage and a central scar. The nearest perpendicular margin is 0.5 cm from the tumor. No extension into perinephric adipose tissue is identified grossly. Remaining kidney appears to be unremarkable.. INK CODE: Black - parenchymal margin. SECTION CODE: B1, representative section of tumor with nearest perpendicular parenchymal margin; B2-B13, multiple representative sections of tumor with nearest margin and adjacent normal kidney. SL/amf *FS/DX: ONCOCYTIC NEOPLASM, DEFER FOR PERMANENT; MARGIN FREE OF TUMOR, TUMOR GROSSLY 0.5 CM FROM NEAREST PARENCHYMAL MARGIN. 1
+
+--- Page 2 ---
+(C) LEFT PARTIAL KIDNEY INFERIOR MARGIN - A 0.4 x 0.3 x 0.2 cm fragment of red-tan tissue. Entirely submitted for frozen section analysis in C.. *FS/DX: MARGIN NEGATIVE FOR TUMOR. RT/FVL:DO/mgd (D) LEFT PARTIAL KIDNEY, INFERIOR/LATERAL - A 2.2 x 0.8 x 0.4 cm, gray-brown fragment of soft tissue. Entirely submitted for frozen section evaluation in D.. *FS/DX: RENAL PARENCHYMA, NO TUMOR PRESENT. FVL:DO/mgd (E) LEFT PARTIAL KIDNEY, LATERAL - A 0.8 x 0.5 x 0.2 cm and 0.3 x 0.2 x 0.2 cm fragment of soft tissue. Both fragments submitted entirely for frozen section evaluation in E. *FS/DX: RENAL PARENCHYMA, NO TUMOR PRESENT. FVL:DO/mgd (F) SUPERIOR MARGIN LEFT KIDNEY - A 1.0 x 0.5 x 0.4 cm fragment of tan soft tissue. Submitted entirely for frozen section evaluation in F. *FS/DX: RENAL PARENCHYMA, NO TUMOR PRESENT. FVL:DO/mgd (G) SUPERIOR/LATERAL MARGIN LEFT KIDNEY - A 1.2 x 0.8 x 0.3 cm fragment of tan soft tissue. Submitted entirely for frozen section evaluation in G.. *FS/DX: RENAL PARENCHYMA, NO TUMOR PRESENT. FVL:DO/mgd (H) LEFT KIDNEY DEEP/MEDIAL - A 0.8 x 0.4 x 0.2 cm fragment of tan-brown soft tissue. Submitted entirely for frozen section evaluation in H. *FS/DX: RENAL PARENCYMA, NO TUMOR PRESENT. FVL:DO/mgd (I) LEFT PARTIAL KIDNEY, DEEP/LATERAL - Two fragments, 0.6 x 0.2 x 0.2 cm and 0.3 x 0.3 x 0.2 cm; submitted entirely for frozen section evaluation in I.. *FS/DX: RENAL PARENCHYMA, NO TUMOR PRESENT. FVL:DO/mgd (J) LEFT ADRENAL GLAND - A 7.0 x 4.0 x 1.0 cm piece of lobulated yellow-tan adipose tissue containing a 4.0 x 2.5 x 0.7 cm adrenal gland and a segment of vein (1.5 cm in length and 0.4 cm in diameter). The adrenal cortex and medulla appear unremarkable. SECTION CODE: J1, J2, representative sections of adrenal gland including cross section of vein.. (K) LEFT PERIAORTIC LYMPH NODES - A piece of lobulated yellow-tan adipose tissue (9.0 x 3.0 x 0.5 cm). Six possible lymph nodes are identified ranging in size from 0.5 to 0.7 cm. Also present are two firm areas, possibly fibrosis.. SECTION CODE: K1, K2, three possible lymph nodes, each; K3, K4, one possible lymph node serially sectioned.. CLINICAL HISTORY Left renal.. SNOMED CODES 2
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diff --git a/output/text/445b3b84-b7bb-48dc-ad03-c2d6655112de.txt b/output/text/445b3b84-b7bb-48dc-ad03-c2d6655112de.txt
new file mode 100644
index 0000000000000000000000000000000000000000..507607bc6c3d69049e841ec9ca046d443649e3d4
--- /dev/null
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+
+--- Page 1 ---
+IcD6-3 orsennro, reual cell ChomephoW Lype 8817|3 SURGICAL PATHOLOGY Sute WKedrey NsS Case Number : C64.9 AS 8|9113 Diagnosis: A. Kidney, left, partial nephrectomy Histologic tumor type/subtype: chromophobe renal cell carcinoma Sarcomatoid features: not identified Histologic grade (if applicable): not applicable Tumor size (greatest dimension): 3.8 cm by gross examination Tumor focality: unifocal Extent of tumor invasion (if present specify if macroscopic or microscopic) : Capsular invasion/perirenal adipose tissue: not identified. Gerota' s fascia: not applicable Renal sinus: not identified Major veins (renal vein or segmental branches, Ivc): not identified Ureter: not applicable Venous (large vessel): not identified Lymphatic (small vessel): not identified Histologic assessment of surgical margins: Renal parenchymal margin (partial nephrectomy only): negative Renal capsular margin (partial nephrectomy only): negative Perinephric adipose tissue margin (partial nephrectomy only): negative Adrenal gland: not submitted UUID:A34F4767-2755-4E12-884C-A8DD949AD1F0 Redacted Lymph nodes: none identified Other significant findings: none AJcc Staging: pTla pNx This staging information is based on information available at the time of this report, and is subject to change pending clinical review and additional information.
+
+--- Page 2 ---
+Comment: Special stains support the diagnosis. The tumor demonstrates. positive staining for Hale's colloidal iron, ck7 and cDll7.' The tumor cells are negative for vimentin, cdio, cD15 and Rcc.. Appropriate controls are performed. Clinical History: The patient is a -year-old man with an incidentally discovered renal mass.. Gross Description: Specimen fixation: formalin Type of specimen: partial nephrectomy Side of specimen: left Size and weight of specimen: 33 grams, 4.8 x 4.6 x 3.6 cm; There. is also a black stitch to mark the tumor capsule, focally ruptured during extraction. Orientation: The fat overlying the kidney capsule is inked blue. The parenchymal margin is inked black. Presence/absence of adrenal gland: absent. Tumor site: Cortex Tumor description: The tumor is a solid, tan, well circumscribed. mass. The tumor abuts the renal capsule and is less than 0.1 cm from the fat overlying the capsule (blue margin), and 0.1 cm from the parenchymal margin (inked black).. Tumor size: 3.8 x 3.4 x 0.2 cm Presence/absence of multicentricity: absent Confinement/non-confinement to the kidney: Confined; the mass. appears to be grossly abutting the capsule but is confined to. kidney. Extent of invasion: Perirenal adipose tissue: does not involve. Gerota' s fascia: n/a
+
+--- Page 3 ---
+Renal vein: n/a Ureter: n/a Renal Sinus: no evidence of invasion. Pelvicaliceal: n/a Adrenal: n/a Other organs: n/a Surgical margins: Perirenal adipose tissue: The tumor is less than 0.1 cm from the blue inked margin.. Renal vein: n/a Renal artery: n/a. Ureter: n/a Description of kidney away from tumor: There is little uninvolved kidney parenchyma present. The tumor is present primarily within the cortex with limited portions of medulla evident, the renal parenchyma is tan/brown and firm.. Hilar lymph nodes: n/a Other significant findings: There is a 7.9 x 5.5 x 0.9 cm additional fragment of adipose tissue received separately in the container, and is grossly unremarkable.. Tissue submitted for Tissue to Digital picture: no. Block summary:. Al,A2 - mass with closest distance to parenchymal margin (inked black) A3,A4 - mass with closest distance to fat overlying capsule and capsule (inked blue) A5 - representative normal with mass. A6 - representative additional free floating fat hv 7/3ef3
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diff --git a/output/text/446f1bd0-49e2-43c4-a6df-e5f4533db165.txt b/output/text/446f1bd0-49e2-43c4-a6df-e5f4533db165.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0913457cf17edc2236cee49672db77f71daaee20
--- /dev/null
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+--- Page 1 ---
+Patient Results m Surgical Pathology Finalj Path Report  Final SUrgiCaL pathOI Ogv reDnrt ACCESSION NO. : Final Diagnosis(es): (A) Kidney, right, partial nephrectomy: tcDo-3 1) Papillary renal cell carcinoma (5.0 cm), Fuhrman grade Orcrsmd yayelssry rinol cell 2 (see Synoptic report). 2) Margins negative. 820/3 (B) Perinephric fat, right side, excision: Benign adipose SuL @$idney NOS tissue, no malignancy identified. C64.9 Synoptic Report: Laterality: Right. OpJ 8/19113 Specimen Procedure: Partial nephrectomy. Tumor Site: Upper pole. Tumor Size: 5.0 x 3.0 x 2.4 cm. Tumor Focality: Unifocal. Macroscopic Extent of Tumor: See Comment. Histologic Type: Papillary renal cell carcinoma, type I. Sarcomatoid Features: Not identified. Tumor Necrosis: Not identified. Histologic Grade (Fuhrman Nuclear Grade): Grade 2.. Microscopic Extent of Tumor: See Comment. Lymphvascular Invaslon: Not identified. Margins: Parenchymal: Negative. Soft Tissue: Negative. Regional lymph nodes: Cannot be assessed, pNX. Pathologic Staging: pT1b NX MX (see Comment). Pathologic Findings in Non-Neoplastic Kidney: None identified.. Comments: The capsule overlying the tumor was disrupted prior to receipt of the specimen, with tumor contents spilling out of the superior pole. However, sections of the adjacent perinephric fat show no definitive invasion, fibrosis or inflammation. Therefore, we favor that the neoplasm was confined to the kidney prior to surgery and is therefore staged pT1b. This case has been reviewed and the diagnosis approved by consulting departmental surgical pathoiogy staff. 'The gross description and all microscopic slides have been reviewed and intamratad hy the undersigned pathologist' UUID:DE07E256-6D0C-4931-A960-628499919477 TCGA-A4-A772-01A-PR Redacted tlectronically Signed Specimen(s) keceivea: A: Right partial nephrectomy B: Perinephric fat right side Printed from: Page: 1 of 4
+
+--- Page 2 ---
+Patient Resultsd M Clinical History: Right renal mass. (A) Tumor Board. Intraoperative Consultation:. Time Recelved: Time Reported: FSA1-FSA4: Right partial nephrectomy: Renal resection margin free of tumor. Gross Description:. (A) (right partial nephrectomy -FS). Specimen components and dimensions: Received fresh for intraoperative consultation are 43.0 gm, 6.5 x 6.0 x up to 0.3 cm portion of resected kidney, attached perinephric fat with extruding soft brown friable material; and several fragments of red-yellow adipose tissue, weighing 440 gm, and measuring 20.0 x 14.0 x 5.0 cm in aggregate dimensions. The parenchymal margin on the resection specimen grossly appears free of tumor. The parenchymal margin is submitted en face for frozen section evaluation as FSA1-FSA4. Size, appearance and locatlon of tumor: The lesion erodes into/extrudes out from the pole of the resection specimen, and measures 5.0 x 3.0 x 2.4 cm. It is thinly encapsulated adjacent to the adjacent renal parenchyma and consists largely of red-brown friable tissue and debris. The superior aspect merges with the perinephric fat, and is not encapsulated or surrounded by fat.  Renal capsule/Renal sinus: The minimal amount of capsule over the parenchymal resection margin appears grossly free of tumor. Renal sinus is not present. Renal vein: Vascular margins were not submitted Other findings: The perinephric fat is unlformly soft, red-yellow, and grossly free of tumor. There is an 8.5 x 3.5 x 2.0 cm segment of spongy friable red-brown material, consistent with the lesional tissue.d Uninvolved tissues: The adjacent grossly normal renal. parenchyma is red brown and unremarkable. The extra renal fat is soft, red to yellow and without lesion.. Lymph nodes: Lymph nodes were not submitted. Blocks submitted: A5-A7 - full thickness cross section of leslon extending into perlrenal fat A8-A9 - normal parenchyma adjacent on either side of lesion A10 - representative section of additional lesional tissue A11-A12 - representative sections of perinephric fat (B) (perinephric fat right side) Received in formalin is 110 gm, 16.0 x 15.0 x 1.5 cm segment of yellow-red fibroadipose Printed from: Page: 2 of 4
+
+--- Page 3 ---
+Patient Results m tissue. Serial sectioning through the specimen reveals a uniform soft yellow cut surface. Representative sections are submitted in B1-B2. Microscopic Description: Complete microscopic evaluation has been performed. Appropriately reacting controls have been performed and evaluated for all stains on this case as required.. Histopathology has a list of IH antibodies that are regulated as analyte specific reagents (ASR's). These assays were developed and their performance characteristics determined by the They have not been cleared by the US Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary for the ASR's. These tests are not investigational  and are used in standard clinical care. In cases where Immunohistochemistry testing is performed, the following antibodies and their respective clones may be used to determine Her2neu(4B5), CD117(Poly). CD20(L26) Ki67(30-9). Unless otherwise stated in the report, all tissue tested for ERPR by IHC, Her2 by IHC and/or HER2 by FiSH have been fixed as per C.A.P. requirements for a minimum of 6 hours and a maximum of 48 hours. ER, PR, Ki-67, p53 are reported as a semi-quantitative percentage of positively stained nuclei. Her-2/neu and EGFR are scored as follows: No staining at ail is scored as (0), weak,  incomplete membrane staining in any proportion of cells is scored as (1+), less than strong but complete staining in any proportion of cells or complete strong staining in less than 30% of cells is scored as (2+), and strong complete staining in more that 30% of cells is scored as (3+). All studies are performed on tissue fixed in 10% neutral buffered formalln and embedded in paraffin unless otherwise stated in the report.. Printed from: Page: 3 of 4
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diff --git a/output/text/449424f9-fda7-48eb-936c-1c5f90bb54dc.txt b/output/text/449424f9-fda7-48eb-936c-1c5f90bb54dc.txt
new file mode 100644
index 0000000000000000000000000000000000000000..310888f1f2c05e034cb08134c7590ab9437a8a89
--- /dev/null
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+
+--- Page 1 ---
+UUID:B8C192A7-E530-4301-B4D3-FF528A230260 TCGA-OL-A66L-01A-PR Redacted Sample # FINAL PATHOLOGIC DIAGNOSIS A. Right axillary sentinel node #1; biopsy: -One lymph node, no tumor (0/1). B. Right axillary sentinel node #2; biopsy: -One lymph node, no tumor (0/1). C. Right breast lumpectomy; lumpectomy: -Invasive ductal carcinoma with tubulo-lobular features, similar to NAS Carenomo, riyiltotiy dlust previous biopsy, extending into dermis, see below.. 0 8SdD|3 -Separate focus of infiltrating ductal carcinoma (1.0 cm) with dermal SteBurtnsS 0 5o>7 involvement, histologically similar to and superior to first mass.. 5/16/13 -Hemorrhagic fat necrosis at previous biopsy site.. Breast Pathologic Parameters 1. Invasive carcinoma: A. Microscopic measurement: 1.9 cm B. Composite histologic (modified SBR) grade: I. - Architecture: 2 - Nuclear grade: 2 - Mitotic count: 1
+
+--- Page 2 ---
+2.Intraductal carcinoma:not identified 3. Excisional biopsy margins: Free of tumor (2 mm from ante4rior margin) 4.Blood vessel and lymphatic invasion: - Present in dermal lymphatics (C20 and C27) 5.Nipple:N/A 6. Skin: direct extension of tumor. Inked edges free of tumor. 7.Skeletal muscle:absent 8. Axillary lymph nodes: Negative 9.Special studies (see. ): - ER: Strong expression in >90% of invasive tumor nuclei - PR:Strong expression in >90% of invasive tumor nuclei -Her2/neu antigen(FISH):Non-amplified (ratio:1.10 10.pTNM AJCC,7th edition,2010):pT1c(m)NOMX Effective this Checklist utilizes the 7th edition TNM staging system for breast of the American Joint Committee on Cancer (AJcC) and the International Union Against Cancer (UIcC)
+
+--- Page 3 ---
+Clinical History: The patient is a -year-old female with right breast lump undergoing right. breast lumpectomy, right axillary s-node biopsy.On bilateral diagnostic mammography/R UTs-Right revealed a 1.7 cm area of architectural distortion in the mid posterior depth in the right breast with no associated calcifications.Breast MRI on showed a right breast unifocal suspicious abnormality at 5 o'clock that measures 19 x 19 x 14 mm.On right UTS core biopsy at 5 o'clock revealed IDC, with tubular-lobular features, Grade 1 with associated microcalcifications Specimens Received: A: Right axillary sentinel node #1 B: Right axillary sentinel node #2 C:Right breast lumpectomy; lumpectomy Gross Description: The specimens are received in three containers each labeled with the patient's name and medical record number..
+
+--- Page 4 ---
+A. The first container is additionally identified as, 'right axillary s-node -1'.Received fresh for frozen section diagnosis is one lymph node measuring 2.0 x 1.6 x 0.5 cm, which is bisected for frozen and diagnosed as, 'one lymph node, no tumor present,' per Dr. Specimen is entirely submitted in A1 FS. B. The second container is additionally identified as, 'right axillary s-node. -2'. Received fresh for frozen section diagnosis is one lymph node measuring 1.5 x 0.5 x 0.3 cm that is frozen and read as, 'one lymph node, no tumor present,' per Dr., The specimen is entirely submitted in B1 FS c. The third container is additionally identified as, 'right breast Iumpectomy'. Received fresh is a 92.6 gm lumpectomy specimen measuring 9.6 cm. from medial to lateral, 7.7 cm from superior to inferior and 2.7 cm from anterior to posterior. A double short suture designates superior, and a double long suture designates lateral. No single short stitch is found although the container label states that there is a single short stitch at the anterior aspect; however there is a portion of skin that designates the anterior aspect that measures 7.5 x 1.5 cm. The margins are inked as follows: anterior-black posterior-red superior - blue inferior- green
+
+--- Page 5 ---
+medial - yellow lateral-violet The specimen is serially sectioned from medial to lateral into 17 slices. There is a 1.5 x 1.0 x 0.9 cm firm, white, stellate mass, with a central dark gray-brown area, located in slices 8 through 10 in the anterior/central aspect of the specimen. It is located 1.0 cm from the black margin, 2.2 cm from the red  margin, 2.0 cm from the blue margin and 2.0 cm from the green margin. A metallic clip is identified in slice #10, adjacent to the mass. Superior to the mass and in slices 6 through 11 is a brownish focus consistent with hemorrhage measuring up to 1.0 x 1.0 cm, most prominent in slice 11. Representative sections are submitted as follows: C1: Entire medial margin, serially sectioned C2-C3: Entire lateral margin, serially sectioned C4-c8: Slice #9 including lesion C9-C14 Slice #10 including lesion C15-C18: Slice #8 with some tissue removed for banking C19-C22:Slice#7 c23-c27: Slice #11, with hemorrhagic lesion most prominent in C26 C28-C29: Slice #3, including skin in C29 C30-C33:Slice #15 Tissue fixed for at least 6 hours in 10% NBF and no more than 72 hours.
+
+--- Page 6 ---
+, m.d. Pathologist Sign Out:  4/12 SQUALIHIED
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diff --git a/output/text/44c57a90-b5af-4f6a-bdf9-37f7eee85883.txt b/output/text/44c57a90-b5af-4f6a-bdf9-37f7eee85883.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2d3cffa4fa2a5af7ae21c6dc2c813f1645798748
--- /dev/null
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+--- Page 1 ---
+DIAGNOSIS (A) PERINEPHRIC FAT, PERMANENT: Adipose tissue, no tumor present. (B) RIGHT RENAL MASS, UPPER POLE, INKED AT MARGIN: RENAL CELL CARCINOMA, CONVENTIONAL (CLEAR CELL) TYPE, FUHRMAN NUCLEAR GRADE 3 (5.5 CM). Parenchymal margin, free of tumor. (C) PERINEPHRIC FAT ADDITIONAL: Fibroadipose tissue, no tumor present.. GROSS DESCRIPTION (A) PERINEPHRIC FAT, PERMANENT- Two portions of adipose tissue (11.5 x 4.5 x 1.5 cm and 9.0 x 5.5 x 2.0 cm) are homogenous without lesion. SECTION CODE: A1-A5, representative portion. (B) RIGHT RENAL MASS UPPER POLE, INK AT MARGIN - A partial nephrectomy specimen (8.0 x 7.0 x 3.5 cm). A solid well- circumscribed tumor (5.5 x 5.0 x 3.0 cm) is identified 2.0 mm from the purple inked parenchymal margin. It has a variegated appearance with yellow and red hemorrhagic areas. The remainder of the tumor is surrounded by adipose tissue. A photograph is obtained. Portions are submitted for electron. microscopy.e  INK CODE: The purple ink area is re-inked in black.. SECTION CODE: B1, mass with closest perpendicular renal parenchymal margin for frozen section; B2-B5, tumor with perpendicular renal parenchymal margin; B6-B9, tumor with adjacent adipose tissue. *FS/DX: MARGIN, FREE OF TUMOR. (C) PERINEPHRIC FAT ADDITIONAL - A single portion of adipose tissue (21.0 x 14.0 x 3.5 cm) has attached fascia without gross lesion. SECTION CODE: C1-C6, representative portions of adipose tissue and fascia CLINICAL HISTORY History of right renal mass. SNOMED CODES T-71000, M-82123
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diff --git a/output/text/44d4a28e-7188-41c3-9f61-975b0d40162c.txt b/output/text/44d4a28e-7188-41c3-9f61-975b0d40162c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..51de47a87c27975bf433f2e8b6caa9ad5f26aaf5
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+--- Page 1 ---
+ics -0-3 Carciomn; mifyiItratNy duct,N0s 85o|3 12810 S.te Codu: breast, Nos c50.9 TSS: UUID:0F708C6E-0262-46EE-8ED2-67E791D5C379 Redacted SPECIMENS: TCGA-E2-A15R-01A-PR A. SLN 1 RIGHT AXILLA B. SLN 2 RIGHT AXILLA C. SLN 3 RIGHT AXILLA D. SLN 4 RIGHT AXILLA E. RIGHT BREAST SPECIMEN(S): A. SLN 1 RIGHT AXILLA B. SLN 2 RIGHT AXILLA C. SLN 3 RIGHT AXILLA D. SLN 4 RIGHT AXILLA E. RIGHT BREAST INTRAOPERATIVE CONSULTATION DIAGNOSIS: TPA, Lymph node, sentinel, right axilla, biopsy: Negative for carcinoma. TPB, Lymph node, sentinel, right axilla, biopsy: Negative for carcinoma. TPC, Lymph node, sentinel, right axilla, biopsy: Negative for carcinoma TPD, Lymph node, sentinel. right axilla, biopsy: Negative for carcinoma Diagnoses called at by Dr. GROSS DESCRIPTION: A. SLN 1 RIGHT AXILLA  Received fresh labeled with the patient's identification and designated "sentinel lymph node number one right axilla" is a tan lymph node measuring 2.2 x 1 x 0.8 cm. Touch preparation is performed. Entirely submitted, A1. B. SLN 2 RIGHT AXILLA  Received fresh labeled with the patient's identification and designated "sentinel lymph node number two right axilla" is a tan lymph node measuring 1.5 x 1 x 0.8 cm. Touch preparation is performed. Entirely submitted, B1. C. SLN 3 RIGHT AXILLA  Received fresh labeled with the patient's identification and designated "sentinel lymph node number three right axilla" is a tan lymph node measuring 0.6 x 0.4 x 0.3 cm. Touch preparation is performed. Entirely submitted, C1.. D. SLN 4 RIGHT AXILLA Received fresh labeled with the patient's identification and designated "sentinel lymph node number four right axilla" is a tan lymph node measuring 1 x 0.6 x 0:4 cm. Touch preparation is performed. Entirely submitted, D1. E. RIGHT BREAST  Received fresh labeled with the patient's identification and designated "right breast"' is an oriented, 27 g, 5.3 x 4.5 x 3 cm lumpectomy specimen. The short suture designates superior, long-lateral. Ink code: Anterior-yellow, posterior-  black, medial-green, lateral-red, superior-blue, inferior-orange. The specimen is serially sectioned from superior to.  inferior into 5 slices to reveal a firm lobulated tan mass, 2.2 x 1.5 x 0.9 cm, located 0.1-cm from the nearest anterior margin. The entire specimen is submitted:. E1-E3: Perpendicular sections superior margin. E4-E7: Slice 2, E5 demonstrating mass and nearest anterior margin E8-E11: Slice 3, E9, E11 demonstrating mass and nearest anterior margin. E12-E15: Stice 4, submitted entirely E16-E18: Perpendicular sections inferior margin DIAGNOSIS: A. LYMPH NODE, SENTINEL #1, RIGHT AXILLA, EXCISION:E - METASTATIC CARCINOMA TO ONE OF ONE LYMPH NODE (1/1), MEASURING 0.3-CM WITH EXTRANODAL EXTENSION, SEE NOTE. B. LYMPH NODE, SENTINEL #2, RIGHT AXILLA, EXCISION: - METASTATIC CARCINOMA TO ONE OF ONE LYMPH NODE (1/1). MEASURING 0.1-CM WITH EXTRANODAL EXTENSION, SEE NOTE C. LYMPH NODE, SENTINEL #3, RIGHT AXILLA, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1). D. LYMPH NODE, SENTINEL #4, RIGHT AXILLA, EXCISION: - METASTATIC CARCINOMA TO ONE OF ONE LYMPH NODE (1/1), MEASURING 0.6-CM WITH EXTRANODAL EXTENSION, SEE NOTE.
+
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+E. BREAST, RIGHT, WIDE LOCAL EXCISION: - INVASIVE DUCTAL CARCINOMA, SBR GRADE 2, MEASURING 1.9-CM - INTERMEDIATE NUCLEAR GRADE, DUCTAL CARCINOMA IN SITU, SOLID TYPE - INVASIVE TUMOR PRESENT 0.15-CM FROM MEDIAL AND 0.1-CM FROM ANTERIOR SURGICAL RESECTION MARGINS - FOCAL LYMPHOVASCULAR INVASION IDENTIFIED - BIOPSY SITE CHANGES WITH FIBROSIS, - SEE SYNOPTIC REPORT AND SEE NOTE NOTE: The touch preparation of SLN #1 and 2 shows no tumor cells. Therefore the false negativity is due to sampling error. The touch preparation of SLN #4 shows two clusters of atypical cells. Dr. concurs. A few clusters branching out and focally separated from the main tumor mass are identified in a close proximity to  the medial margin (0.15-cm). The main tumor mass is 0.1-cm from the anterior surgical resection margin. SYNOPTIC REPORT - BREAST Specimen Type: Excision Needle Localization: Yes - For mass Laterality: Right Invasive Tumor: Present Multifocality:  No  WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Tumor size: 1.9cm Margins: Negative Distance from closest margin: Less than 0.15cm  medial and anterior Tubular Score: 3 Nuclear Grade: 2 Mitotic Score: 2 Modified Scarff Bioom Richardson Grade: Necrosis: Absent  Vascular/Lymphatic Invasion: Present Extent:  focal Lobular neoplasia:  None Lymph nodes: Sentinel lymph node Lymph node status: Positive 3 / 4 Extranodal extension DCIS present Margins uninvolved by DCIS DCIS Quantity:Estimate 5% DCIS Type: Solid DCIS Location:Associated with invasive tumor Nuclear grade: Intermediate Necrosis: Absent ER/PR/HER2 Results ER: Positive  PR: Positive HER2: Negative by FISH Performed on Case: Pathological staging (pTN): pT 1c N 1  Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition CLINICAL HISTORY:  year-old female right breast mass, invasive ductal carcinoma on core bx. Right needle localization excision with sentinel lymph node biopsy PRE-OPERATIVE DIAGNOSIS: Carcinoma, right breast Gross Dictation:  Microscopic/Diagnostic Dictation: Pathologist, Final Review: Pathologist, Final: Pathologist,
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diff --git a/output/text/44e13264-a03c-4ff6-8316-94930ddec210.txt b/output/text/44e13264-a03c-4ff6-8316-94930ddec210.txt
new file mode 100644
index 0000000000000000000000000000000000000000..10a4a93db960945cf65c861b97debda32889a383
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+UUID:D2679879-7287-4515-9496-B1FCE87C8571 TCGA-A6-A566-01A-PR Redacted jcs-o-3 adnocaicinonk Mucnous NO5 848o/3 SURGICAL PATHOLOGY REPORT Sitx : cdon, diuscerdiy c18.b SPECIMEN A. Apical lymph node 1/4/3 B. Left hemicolectomy, left nephrectomy, distal pancreas, spleen, proximal jejunum c. Appendix CLINICAL NOTES CLInIcAL HIsToRy: Carcinoma descending colon invading hilum left kidney, distal pancreas, segment of jejunum. GROSS DESCRIPTION A. The specimen is Received in formalin, labeled "apical lymph node" and consists of a piece of tan and yellow tissue measuring 1.2 x 1 x 0.4 cm. bisected As-1 after fixation. AS-1. B. The specimen is received unfixed labeled "left hemicolectomy, left nephrectomy,  distal pancreas, spleen, proximal jejunum" and consists of a complex specimen comprising kidney measuring 11 x 7.5 x 5.3 cm., spleen measuring 14 x 7 x 5 cm. stapled margin. There is some omentum on the specimen and there is a small amount of pericolonic fat. There are no palpable nodes in the pericolonic fat. There is an adherent segment of bowel centrally that might represent small bowel that measures 8 cm. in length and 4 cm. from diameter. The small segment of bowel that looks like it might be adherent to small bowel has fungating tumor centrally. The measures 6.5 cm. in diameter by external palpation of his roughly spherical. A portion of tumor and normal colon are taken for research purposes.  Sections through the tumor taken after fixation show carcinoma invading the lower pole of the kidney and a portion of pancreas measuring 7 x 3 x 2 cm. BLOck suMMARy: #B1, 2 - Colonic and small bowel margins of resection; B3 - 7 - colonic tumor; B8, 9 - pancreas; B10, 11 - spleen; B12 - 15 - kidney and ureter; B16 - 18 - pericolonic lymph nodes. C. The specimen is Received in formalin, labeled "appendix" and consists of a tan vermiform appendix measuring 4.7 cm. in length and 0.5 cm. in diameter.  The appendix measures 5 x 1.2 x 0.7 cm. . AS-2 The tip of the appendix and the. proximal end are in block #l. Sections after fixation.. MICROSCOPIC DESCRIPTION A. A single lymph node is negative for malignancy. B. Tumor type: Colonic adenocarcinoma with areas of mucinous differentiation Tumor grade: 2 out of 3 Tumor size: 7 cm. Distance to nearest margin: 14 cm.
+
+--- Page 2 ---
+Level of penetration: Carcinoma penetrates through the muscularis propria of the colon into adjacent pancreas and kidney. Margins of resection:  Negative for malignancy Vascular invasion:  There are areas suspicious for lymphatic invasion in pericolonic soft tissue. Host response:  Mild chronic inflammation Attached lymph nodes:  Metastatic carcinoma is present in two of thirteen lymph nodes. The largest metastasis is 0.7 cm. in dimension. pTNM Stage: T4 N1 Other findings: Sections of pancreas, spleen and kidney are otherwise unremarkable. The spleen is not involved by the tumor. C. Sections of appendix are unremarkable. DIAGNOSIS A. Apical lymph node, biopsy: A single lymph node is negative for malignancy. B. Left colon, left kidney, distal pancreas, spleen, proximal. jejunum, resection: Moderately differentiated colonic adenocarcinoma.. Note:  Carcinoma invades into the adjacent jejunum, kidney and pancreas. Metastatic carcinoma is present in two of thirteen pericolonic lymph nodes. C. Vermiform appendix, resection: No pathological diagnosis. - End Of Report
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diff --git a/output/text/44ea4ffc-1014-4f4d-80b3-9eb9d4514660.txt b/output/text/44ea4ffc-1014-4f4d-80b3-9eb9d4514660.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0b8bd9cd14a8cae5339e0065d4d5b324caa97a3f
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+Date Coll: SURGICAL PATHOLOGY REPORT SPECIMEN Left hemicolectomy CLINICAL NOTES PRE-OP DIAGNOSIS:  Descending colon cancer. GROSS DESCRIPTION Received fresh subsequently fixed in formalin labeled "left hemicolectomy" is a 28 cm. long portion of colon. The specimen is open at both ends, arbitrarily inked blue and black.  There is pink-tan smooth glistening serosa.  The peritoneal reflections cannot be grossly identified.  The specimen shows an umbilication midway through the specimen. This area of umbilication is inked Orange. The specimen is opened to show a pink-tan smooth,. glistening mucosa with normal to abundant folds with an average circumference of 5 cm.  Located near the umbilication is a 4.8 x 4.0 cm. circumferential ulcerated lesion. The cut surface of this lesion shows invasion into the muscularis propria, coming within 7.5 cm. of the radial margin, contiguous with the umbilication previously described.  The cut surface shows multiple diverticula present.  No discrete gross evidence of submucosal abscess or perforation identified. There is a firm nodule in the fatty tissue on cut surface it is grossly consistent with a diverticula containing firm formed fecal material. No other discrete gross lesions identified. Multiple lymph nodes are grossly identified. Representative sections of the specimen are submitted as follows: BLOCK SUMMARY: 1 - Representative luminal margins; 2. representative section of diverticula with firm fecal material; 3 tumor to umbilication; tumor to normal; tumor t to fat; representative section of radial margin; 7 - possible mottled lymph node subjacent to tumor; 8 - 3 possible lymph nodes; 9 - 8 possible lymph nodes; 10 - 9 9 possible lymph nodes; 11 - 10 possible lymph. nodes; 12-14 - 9 possible lymph nodes; 12-15 - 9 possible lymph nodes; 16  - 6 possible lymph nodes; 17 - 6 possible lymph nod 18 3 possible lymph nodes. AS-18. MICROSCOPIC DESCRIPTION Histologic type: Adenocarcinoma Histologic grade:  Moderately-differentiated Primary tumor (pT3): Carcinoma into and through muscularis propria, into the subserosal fat. Proximal/distal/radial margins: Negative. Vascular invasion: Not identified. Regional lymph nodes (pN): Metastatic carcinoma in 1 of 65 lymph nodes (1/65). Non-lymph node pericolonic tumor: One focus, in area of main tumor mass (possibly a lymph node replaced by carcinoma). Other findings: diverticuli, multiple. 5
+
+--- Page 2 ---
+DIAGNOSIS Adenocarcinoma, moderately-differentiated, with invasion through the muscularis propria into the subserosa.. Negative margins of excision.. Metastatic carcinoma in one of sixty-five lymph nodes (1/65). One focus of pericolonic tumor (possible lymph node), adjacent to main tumor mass.. End Of Report
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diff --git a/output/text/44f219e5-900d-4dfb-aa54-967e702a9f40.txt b/output/text/44f219e5-900d-4dfb-aa54-967e702a9f40.txt
new file mode 100644
index 0000000000000000000000000000000000000000..eeb48c23e78b8a8dab96bdfcf424ca40049a16c7
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+UUID:0CC07903-EB90-47B5-B554-599A67C9E12A TCGA-AN-A0FX-01A-PR Redacted TSS Patient ID: Case #: JOB: Sex: Female Ethnicity (Race): Cancer Samplee Diagnosis: Breast Cancer Histological description: metaplastic carcinoma Date of Procurement: Anatomic Site: Left Breast Tumor location: Primary. Tissue Specification: Tumor Specinen Matrix: Tissue Specimen Format: Frozen Container: cryomold Type of Procurement: Radical mastectomy Grade: 3 T Stage: 2 N Stage: 0 M Stage: 0 Treatiment: none. Treatment Details: n/a  Normal Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw Matrix: Blood Specimen Format: frozen Container: tube. Date of Procurement: Ics-0-3 cavcuiome, mutp1esHc,Nos 8575/3 Sift: hrast Nos C5o.4 h io|oJh C QcF - catcrmn,nf{tnnHmq duchl N0s o5vr/3 s70+f1
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diff --git a/output/text/4533dd63-7ead-409b-a6a3-cdcedfee8eb0.txt b/output/text/4533dd63-7ead-409b-a6a3-cdcedfee8eb0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a5c46e5042b14a349660b08ab6be057fdaf1f8db
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+--- Page 1 ---
+Lab Results : Single Panel. Page I of 4 Lab Results : Single Panel :. 1c0-0-3 carciiome,. squamuv cilL,N0s 8O70/3 008 Sex Race (MRN(S) Site: cern'x, Nus C53.9 hJ 9|8fn Panel: Suraicat Pathology Report Date: Abnormal rrags key. C Critlcal H High _L Low R Review * Abnormal Interpretation Codes: (S) Susceptible (R) Resistant (MS) Moderately Susceptible (I) Intermediate Status codes: p-Preliminary F-Final c-Corrected I-In progress/Incompiete x-Cancelled Dates and times displayed below are collection dates; to see the observation date and time for a result, hoid your course over the collection time. Times are on a 24-hour clock. An asterisk [*] in the Note column or next to a panel name indicates a note is present. To view it, rest your mouse cursor on the [*]. Panel Accesslon # Sts Test. Collected Value Units Range. Surgical Pathology Report F Collection D/T: Obsv D/r Surgical Pathology Report UUID:3810E8FD-27A9-4E65-9BD2-BFA559481388 TCGA-EK-A2RM-01A-PR Redacted Final Diagnosis 1. Right aortic node, excislon: Two lymph nodes, no tumor seen (0/2). 2. Left pelvic node, excision:. Eighteen lymph nodes, no tumor seen (0/18).. 3. Right pelvic node, excision:. Sixteen lymph nodes, no'tumor seen (0/16). 4. Portion of right parametrium, excision:.  Portion of large blood vessel and associated fibroadipose. tissue; no tumor seen. 5. Portion of left parametrium, excision: 6. Uterus, tubes and ovaries, parametrium of upper vagina,. 233.3g, hysterectomy and bilateral salpingooophorectomy:. A. Invasive squamous cell' carcinoma, poorly differentiated, 4.5. cm in maximum dimension, invasive to a depth of approximately 1.1 cm out of 2.0 cm of cervical wall, serosa not involved. 3. Parametrial margins negative for carcinoma. C. Vaginal cuff margins negative for carcinoma D. Lymphovascular invasion present. F. Bilateral fallopian tubes with no specific pathologic change. 7. Left uterine artery. Sections of artery and associated fibroadipose tissue; no tumor. seen, The rase material was reviewed and the report verified by:
+
+--- Page 2 ---
+M Lab Kesuns Page 2 of 4 Verifiration Date: Patholnnist(s) Frozen Section Diagnosis 1A: Lymoh nodes. no tumor seen. Reported to Gross Description The case is received in seven containers, each with the patient's name and medical record number. Specimen 1 is designated "right aortic node" and is received fresh for frozen section and is described then as one piece of red-tan soft tissue measuring 2.5 x 2.0 x 1 cm and dissected to reveal multiple potential Tymph hodes frozen in toto as 1A. The remaining specimen Is now received following formalin fixation and is submitted as 1A in toto. Specimen 2 is received fresh and is labeled "teft pelvic node". The Specimen consists of multiple fragments of yellow-tan soft tissue measuring 6.1 x 4.1 x 1.2 cm in aggregate. Further dissection reveais six potential Tymph nodes, as large as 1.2 cm, which are dissected and submitted in 2A-C Specimen 3 is received fresh and is labeled *right peivic node". The  specimen consists of multiple fragments of tan fatty soft tissue measuring 5.8 x 3.7 x 1.4 cm aggregate. The specimen contalns multiple potential Tymph nodes as large as 0.9 cm, and are submitted in 3A through 3D. Specimen 4 is received fresh and is labeled "portion of right parametrium". The specimen consists of one portion of tan soft tissue measuring 1.2 x 0.9 x 0.2 cm and is submitted in toto in 4A. Specimen 5 is received fresh and is labeled portlon of left parametrium. The specimen consists one portion of tan soft tissue measuring 1.6 x 0.8 x 0.3 cm, and is submitted in toto in 5A. Specimen 6 is received fresh and is labeled "uterus, tubes and ovaries, parametrium of upper vagina". The specimen weighs 233.3 grams in toto. The uterus measures 7.9 cm superior to inferior, 7.1 cm cornu to cornu, and 3.5 cm anterior to posterior, and measures 3 cm in length, 4.6 cm lateral to Jateral, and 4.4 cm anterlor to posterior. The cervix is notable for a protruding friable red-tan mass appearing to be a posterlor lesion. The
+
+--- Page 3 ---
+I.ab Results : Single Panel :. Page 3 of 4 specimen also contains a cuff of vagina measuring from 1.2 to 2.7 cm, and grossly free of tumor. The serosa of the uterus and cervix Is smooth and glistening. The uterus and cervix are bivalved along the anterlor-posterlor border to reveal the following: An endocervical canal 4.0 long, 0.4 cm ls  wide, an unremarkable endometrlal cavity 4.6 cm long, and 3.9 cm wlde, and 0.1 cm thick, and a myometrium notabie for a thickness of 1.4 cm. The Specimen Is Inked as following: Biack is anterlor, green Is posterlor, and Ehe vaginal cuff is inked blue. The posterlor ectocervix is replaced by a fungating mass leslon measuring 4.5 cm lateral to lateral and 2.9~cm anterior to posterior x 2.6 cm superlor to Inferlor, with a tan- white Surface. The mass lesion Is tocated approximately 1 cm from the lower uterine segment posteriorly, and 1.5 cm from the anterior uterine segment. The mass Is located 1.5 cm from the closest vaginal margin. Right and left parametria are shaved. They are grossly uninvoived by tumor. The left parametrial are submitted in toto in 6A through D, and the right parametrial Is submitted in 6E through 6H. The vaginal cuff is submitted as follows: Left anterior cuff in 6I, right anterlor cuff and 6J, and left posterior cuff in 6 K and right posterior cuff in 6L. An uninvolved portion of vaginal cuff is cut off. The cervix is then processed as a cone, and submitted as follows: 2:00 as 6M, 12:30 as 6N, 1:00 as 6O, 2:00 as 6P, 2:30 6Q, 3:00 as 6R, 3:30 as 6S, 4:00 as 6T, 4:30 in 6U and 6V, 5:00 in 6W and 6X, 6:00 in 6Y and 6Zand 7:00 as 6AA and 6BB, 8:00 as 6CC, 8:30 as 6DD, 9:00 as 6EE, 9: 30 as 6FF, 10:00 as 6GG, and 11:00 as 6HH. A sectlon through anterior endocervix and lower uterine segment is submitted in 6II, and a section through posterior endocervix and lower uterine segment is. submitted in 6JJ. A full thickness cross-section through anterior endometrlum and myometrium is submitted in 6KK and a full thickness cross section through posterior endometrium myometrium is 6LL. The right ovary measures 4.0 x 2.8 x 1.8 cm and the right fallopian tube measures 3.3 cm x 0.3 cm in greatest dimension, Upon sectioning, the right ovary multicystic and hemorrhagic with the cysts as large as 1.5 cm S in diameter. Section through right ovary and adjacent falloplan tube is submitted in 6MM and representative sections of the right fallopian tube which looks grossly unremarkable is submitted in 6NN. The left ovary measures 3.7 x 2.9 x 1.2 cm and the left fallopian tube measures 3.6 cm x 0.3 cm in greatest diameter. Upon sectloning, the left ovary is cystic and has a cyst as large as 0.6 cm."A representative section of ovary with adjacent fallopian tube 1
+
+--- Page 4 ---
+I.ab Results : Single Panel : Page 4 of 4 Is submitted in 600. The fallopian tube looks grossly unremarkable and representatlve sections are submitted in 6PP. Specimen 7 is received fresh and is labeled "left uterine artery". The speclmen consists of one portlon of yellow-tan soft tissue measurlng 2.0 x 1.2 x 0.3 cm. The specimen is submitted in toto and 7A. SUMMARY OF SECTIONS: 55. mult!ole, representatIve sections Dictator: ' Nirtated by: Clinical Information -year-old with newly diagnosed SCCa cervix by coiposcoov and blopsies . No infectious precautions, chemotherapy, radiatlon or blopsy. Pre-Operative Diagnosis: Post-Operative Dlagnosis: Operatlon: RAH/BSO Speciflc questtons to be answered: Specimen: 1. Right aortlc node 2. Lelt pelvic node. 3. Right pelvis node 4. Portion of rlght parametrium 5. Portion of lelt parametrium' 6. Uterus, tubes and ovarles, parametrium of upper vagina 7. Left uterine artery ** End of report [ End
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diff --git a/output/text/45387440-7ca7-4be3-bf40-5a50f619965c.txt b/output/text/45387440-7ca7-4be3-bf40-5a50f619965c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3e8962758fa79f4b586671192f5ce10a8202c9bf
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+Clinical Diagnosis & History:. Patient with left breast cancer IFDc on core left MRm and right prophylactic TM and SLNB. Specimens Submitted: 2: SP: Right breast 3 SP: Level 3 axillary contents. 4: SP Sentinel node #i. level one right axilla 5: SP Sentinel node #2. lovel one right axilla DIAgNOSIs: 1) BREAST, LEFT AND AXILLARY CONTENTS, LEVELS I AND II; EXCISION: INVASIVE DUCTAL CARCINOMA, WITH MEDULLARY FEATURES, HISTOLOGIC GRADE II/III (MODERATE TUBULE FORMATION). NUCLEAR GRADE III/III (MARKED VARIATION IN SIZE AND SHAPE), MEASURING 2.3 CM IN LARGEST DIMENSION MICROSCOPICALLY. - DUCTAL CARCINOMA IN SITU (DCIS) IS ALSO IDENTIFIED, SOLID TYPE WITH HIGH NUCLEAR GRADE AND EXTENSIVE NECROSIS. -THE DCIS CONSTITUTES <- 25t OF THE TOTAL TUMOR MASS, AND IS PRESENT ADMIXED WITH THE INVASIVE COMPONENT - THE INVASIVE CARCINOMA IS LOCATED IN THE LOWER OUTER QUADRANT. IS LOCATED IN THE LOWER OUTER QUADRANT. THE DCIS - NO INVOLVEMENT OF THE NIPPLE BY EITHER IN SITU OR INVASIVE CARCINOMA IS paen IDENTIFIED. - NO CALCIFICATIONS ARE IDENTIFIED IN EITHER THE INVASIVE OR IN SITU CARCINOMA. - NO VASCULAR INVASION IS NOTED. . - NO INVOLVEMENT OF THE SURGICAL MARGINS BY EITHER INVASIVE OR IN SITU CARCINOMA IS IDENTIFIED. - NO SKIN INVOLVEMENT BY CARCINOMA IS IDENTIFIED. THE NON-NEOPLASTIC BREAST TISSUE IS UNREMARRABLE. - THE LYMPH NODE STATUS IS AS FOLLOWS (EXPRESSED AS THE NUMBER OF POSITIVE LYMPH NODES IN RELATION TO THE TOTAL NUMBER OF LYMPH NODES EXAMINED): LEVEL I: 2/13; LEVEL II: 0/4. - THERE IS EXTRANODAL EXTENSION OF CARCINOMA. RESULTS OF SPECIAL STAINS (ER, PR, HER2-NEU) WILL BE REPORTED AS AN 0 ADDENDUM. Myr PATH REPORT b'esD Continued on next page -. 3 -0-0!
+
+--- Page 2 ---
+2 BREAST, RIGHT; EXCISION: - BENIGN BREAST PARENCHYMA WITH SECRSTORY CHANGE. 3) LYMPH NODES. LEFT AXILLA, LEVEL III; EXCISION: TWO BENIGN LYMPH NODES (O/2). LYMPH NODES, SENTINEL #1, LEVEL I, RIGHT AXILLA; EXCISION:S L 4) TWO BENIGN LYMPH NODES0/2). STAINS HAVE SEEN ORDERED. THE RESULTS WILL BE REPORTED IN AN ADDENDUM.  DEEPER LEVEL RECUTS AND SPECIAL 5) LYMPH NODE, SENTINEL #2, LEVEL I, RIGHT AXILLA; EXCISION: - 3ENIGN SREAST TISSUE. NO LYMPH NODE IDENTIFIED. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL). AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Report Electronically Signed Out  Special studies: Result Special Stain Coument HER2-C ER-C pR-C NEG CONT IMM RECUT NEG-HER2 AE1:AE3 CAm 5.2 AE1:AE3 Cam 5.2 NEG CONT IMM RECUT NEG CONT IMM RECUT Gros 1) The specimen is received fresh, labeled. -Left breast & axillary contents levels 1.2 with tags attached". It is a product of left modified mastectomy, consisting of an ellipse of tan skin. breast tissue and axillary tail designated as levels one and two.. The breast tissue measures 23.0 x 23.0 x 6.5 cm. The skin measures 15.0 x 4.0 cm.. measures 14.0 x 6.5 x 2.0 cm.  Tho axillary tail site The nipple is everted. present on the skin surface.  No visible scars are present at the deep margin which is inked.. A scanty amount of sxeletal muscle tissue is. to reveal an ill-defined pink-gray focally hemorrhagic rubbery tumor The breast tissue was sectioned completely surrounded by thickened sibrous tissue situated in the lower Outer quadrant, 3.5 em fron the deep surgical margin.. surrounding the tumor abuts the deep surgical margin. The rest of the tissue The fibrous tissue is predominantly fibrous. PATH * Continued on next page ** REPORT
+
+--- Page 3 ---
+-- ?age 3 of 5 Representative sections were submitted, portion of the tumor was given to. TpS. Susmary of Sections: 3 N  nipple T tumor DM deep margin closest to the tumor UOQ upper outer  quadrant LOQ lower outer guadrant LIQ lower inner  quadrant LN1 lymph  nodes level LN2 one lymph nodes level two 2) The specimen is received fresh, labeled, -Right breast. (stitch marks axillary tail)r. It is a product of right modified mastectomy consisting of an ellipse of tan skin with breast tissue. The skin measures 15.5 x 5.o cm.. The brcast tissue neasures 16.0 x 16.0 x 6.0 cm. The nipple is everted. Grossly no visibie scars are present on the skin surface. Thero is a scanty The breast tissue was sectioned to reveal sibrofatty tissue. The fibrous tissue counts to approximately 55% of the entire breast tissue. evert lesions wero identified.  No lymph nodes were present at the axillary  Grossly no tail site. Represcatative soctions were submitted. Surmary of Sections: N nipple OUQ upper outer quadrant LOW lower outer quadrant UIQ upper : inner quadrant LIQ lower  inner quadrant DM deep margin AXT axillary tail site 3) contents'. It consists of three piece of tibroadipose tissue measuring in aggregate 1.5 x 1.0 x 0.6 cm. Entirely submitted. Summary of Sections:  undesignated 4) The specimen is received in formalin, labeled, "Sentinel node #1. level one, right axilla". It consists of a single piece of adipose tissue. measuring 2.5 x 2.0 x 0.5 cm. Entirely submitted. Summary of Sections:  undesignated PATH Continued on next page REPORT
+
+--- Page 4 ---
+The specimen is received in formalin, labeled. *Sentinel node #2, Page i of s. 51 level one right axilla". It consists of a single piece of fibroadipose tissue with embedded lymph node, measuring 0.s cm in its greatest dimension. Entirely submitted.. Summary of Sections:. LN lymph node Summary of Sections:. Part 1: Block Sect. site 5 PCs ALN BLN 43 1 7 DM 3 LIQ N N LOQ N r UIQ 4 2 2 UOQ Part 2: SP: Right breast Block Sect. Site. PCs 1 AXT DM 4 3 LIQ 42 LOQ N UIQ 4 Part 3: SP: Level 3 axillary contents. Block Sect. Site PCs 1 Part 4: SP: Sentinel node #1, level one right axilla Block Sect. site. pCs 2 u ? Part 5: SP: Sentinel node #2, level one right. axilla Block Sect. Site. pCs 1 LN 1 PATH Continued on next page ** REPORT
+
+--- Page 5 ---
+Page 5 of 5 Procedures/Addenda: Addendum Date Ordered: Date Complete Status: Signed Out Date Reported: By: Addendum Diagnosis. ADDENDUM SITE: LEFT BREAST - ER-ICA:  NEGATIVE - PR-ICA:  NEGATIVE - HER2/NEU (HERCEPTEST) : NEGATIVE (STAINING INTENSITY OF O). CONTROLS ARE SATISFACTORY. Addendum Date Ordered: Date Complete: Status: Sianed Out. Date Reported:. By: Addendum Diagnosis. ADDENDUM SITE: SENTINEL LYMPH NODE, RIGHT AXILLA PART #4. ADDITIONAL H&E STAINED SECTIONS AND IMMUNOHISTOCHEMICAL STAINS FOR CYTOKERATINS (AEI:AE3 AND CAM 5.2) SHOW NO EVIDENCE OF METASTATIC TUMOR. PATH End of Report REPORT
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diff --git a/output/text/4542ad50-1fd2-4758-a808-fc2fe66f4cb0.txt b/output/text/4542ad50-1fd2-4758-a808-fc2fe66f4cb0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..bfeb6b9ec7bd377219b1136f1c59507d2233b5ef
--- /dev/null
+++ b/output/text/4542ad50-1fd2-4758-a808-fc2fe66f4cb0.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+UUID:7FD7340E-0F3A-484E-A5CF-5165BE5E95780 TCGA-KM-A7Q7-01A-PR Redacted Patient Results Page I of 4 Admit Date: Gender: Female Birth Date: Age: Attending: Admit Protocol: Location: Surgical Pathology [OrderID: Final Results  Surgical Pathology  Final CASE NUMBER: DIAGNOSIS: Ied6:3 1. Tumor, #1, left kidney (partial nephrectomy): Renal parenchyma. showing oncocytosis. Benign smooth muscle tumor. (leiomyoma). Drenono,renol ceQl 2. Tumor, #2, left kidney (partial nephrectomy): Renal cell carcinoma, Chromsphobe type 8317/3 chromophobe type (small). Furhman nuclear grade II. Se O K,udny N6 S 3. Tumor, #3, left kidney (partial nephrectomy): Benign smooth muscle C649 tumor (leiomyoma) Qw 9j24113 4. Tumor, #4, left kidney (partial nephrectomy): Renal cell carcinoma, chromophobe type, Furhman nuclear grade II.. 5. Tumor, #5, left kidney (partial nephrectomy): Renal cell carcinoma, clear cell type, Furhman nuclear grade ll. Tumor approaches the inked. margin. 6. Tumor, #5 margin, left kidney (partial nephrectomy): Renal parenchyma with cystic dilatation of tubules.. 7. Tumor, #6, left kidney (partial nephrectomy): Renal parenchyma with. chronic inflammation. 8. Tumor, #7, left kidney (partial nephrectomy): Renal cell carcinoma,. clear cell type, Furnman nudear grade II. See note. Margins appear to be free of tumor. Smooth muscle proliferation is present outside near the capsule. Oncocytosis. 9. Tumor, #8, left kidney (partial nephrectomy): Renal cell carcinoma, clear cell type, Furhman nuclear grade Il. Margins free of tumor. 10. Tumor, #10 normal parenchyma, left kidney (resection): Renal parenchyma with cystic dilatation of tubules. 11. Rib, left 11th (resection): Gross description only NOTE: The morphology of the renal tumors and the presence of smooth  muscle proliferation suggest the possibility of tuberous sclerosis. CLINICAL INFORMATION: Allocate Order to Protocol: Brief Clinical History: Left renal masses Specimen Taken For Protocol: 01 - Yes PROcEDuRE: Pre-Operative Diagnosis: left rena mass Post-Operative Diagnosis: left renal mass Operative Findings: multiple left renal masses Contidential Patient Infornation. Unautharized disclosure is prohibited by the Federal Privacy Act of 1974. JobID: Requested By: Do not file in Medical Record
+
+--- Page 2 ---
+Patient Results Page 2 of 4 Admit Protocol: Age. Gender: Female Birth Date: Admit Protocol: Location: Admit Protocol: Surgical Pathology (OrderID: Final Results SPECIMENS SUBMITTED: 1. TUMOR, #1 - Left Kidney 2. TUMOR, #2 - Left Kidney 3. BIOPSY, NOS, LEVEL 5 SECTIONING, Tumor #3 - Left Kidney 4. TUMOR, #4 - Left Kidney 5. TUMOR, #5 - Left Kidney 6. TUMOR, #5 - Left Kidney Margin 7. TUMOR, #6 - Left Kidney 8. TUMOR, #7 - Left Kidney 9. TUMOR, #9 - Left Kidney 10. KIDNEY, LEFT, Normal Peraychmal 11. RiB,Left 11th GROSS DESCRIPTION: 1. "Tumor #1 left kidney". The specimen consists of a tan tissue fragment measuring 1.2 x 0.5 x 0.5 cm. The specimen consists of a nodule measuring 0.5 cm in diameter with attached renal parenchyma. The specimen.is inked black, bisected, revealing a white/tan homogenous cut surface of the nodule. The soecimen is entirely submitted in a white cassette labeled or serial sectioning. 2. "Tumor #2". The specimen received fresh OR labeled with the patient's name, medical record number, and "tumor #2" is a 1.2 x 0.9 x 0.6 cm, which is greater than 78% solid. 30% is procured for. .The procurement was performed by on at Recaived in Surgical Pathology, the specimen is consistent with the above descrintinn The specimen is entirely submitted in a white cassette labeled . for serial sectioning. 3. "Tumor #3 left kidney'. The specimen consists of a tan nodule measuring 0.3 cm in diameter. The soecimen is inked black and entirely submitted in a white cassette labeled. Tor serial sectioning. 4. Received from OR labaled with the patient's name, medical record number, and "tumor #4 left kidney" is a 4.2 x 2.6 x 0.6 cm specimen with a tumor nodule measuring 2.6 x 3.7 x 2.8 cm with attached renai parenchyma. The specimen is inked black, sectioning of the nodule reveals a homogeneous light brown cut surface. 30% is procured for Representative sections are submitted in white cassettes labeled -4A through 4F serial sectioning. Additional sections are submitted in white cassettes labeled. G to 4N for serial sectioning (8 more cassettes). 5. Received fresh from OR labeled with the patient's name, medical record number, and *tumor #5 left kidney" is a 2.6 x 2.4 x 1.8 cm tumor nodule which is greater than 70% solid. The specimen is inked black; sectioning reveals a homogeneous light brown cut surface. 75% is procured for Research. Received in Surgical Pathology. the specimen is consistent with the description in the procurement note. The specimen is entirely submitted in white cassettes labeled. 5A through 5D for serial sectioning. Confidential Patient Information. Unautharized disclosure is prohibited by the Federal Privacy Act of 1974. JobID: Requested By: : Do not file in Medical Record
+
+--- Page 3 ---
+Patient Results Page 3 of 4 Admit Protocol: Gender: Female Birth Date: Age: Admit Protocol: Admit Protocol: Location: Surgical Pathology [OrderID: Final Results 6. "Tumor #5 left kidney margin" is a tan tissue fragment measuring 1.8 x 1.2 x 0.5 cm. The specimen is inked black and n--ially sectioned, entirely submitted in a white cassette labeled -6 for serial sectioning. 7. "Tumor #6 left kidney". The specimen consists of a tan tissue fragment measuring 0.5 x 0.5 x 0.4 cm. The snarimen is inked black and entirely submitted in a white cassette labeled  .7 for serial sectioning. 8. Received fresh from OR labeled with the patient's name, medical record number, and "tumor #7.left kidney" is a 4.6 x 3.4 x 4.2 cm mass with a tumor nodule measuring 3 x 2.4 x 0.6 cm with attached renal parenchyma. The tumor nodule is greater than 70% solid. The specimen is inked black; sectioning reveals a tan/white cut surface.. Approximately % procured for Representative sections are submitted in white cassettes labeled. -8A to 8G for serial sectionina. Arritional sections are submitted in white cassettes labeled -8H-8L for serial sectioning (5 more cassettes) 9. Received fresh from OR labeled with the patient's name, medica! record number, and *tumor #8 left kidney" is a 1.8 x 1.6 x 1.2 cm tissue fragment. There is a 0:7 x 0.7 cm tumor nodule which is greater than 70% solld. The tumor is nodule is light brown in color.. % was procured for The procurement was performed by. Received in Surgical Pathology, the specimen is consistent wtn the above description. The soecimen is entirely submitted in white cassettes labeled. and 9B for serial sectioning. 10. Received fresh from OR labeled with the patient's name, medical record number, and "normal parenchyma left kidney" is a 2.6 x 1.7 x 0.7 cm renal tissue. 30% was procured for. .: The procurement was performed by on Received in Surgical Pathology, the specimen is consistent with the above description. The specimen is serially sectioned and representative sections are submitted in a white cassette labeled 10A and 10B for serial sectioning. 11. "Left 11th rib". The specimen consists of two bone fragments measuring 1.2 x 1.2 x 0.3 cm and 2.5 x 0.8 x 0.5 cm, respectively. Gross lesions are identified. Gross dictated by No consultants Contidential Patient Information. Unauthorized disclosure is prohibited by the Federal Privacy Act of 1974. JobID: Requested By: Do not file in Medical Record
+
+--- Page 4 ---
+Patient Results Page 4 of 4 Admit Protocol: Birth Date. Gender: Female Age: Admit Protocol: Location: Admit Protocol: Surgical Pathology [OrderID: Final Results , MD, ATTENDING STAFF PATHOLOGIST Contidential Patient Information. Unauthorized disclosure is prohibited by the Federal Privacy Act of 1974. JobID: Requested By: Do not file in Medical Record
\ No newline at end of file
diff --git a/output/text/4559536e-0aa8-4d81-b072-d5fbc1290826.txt b/output/text/4559536e-0aa8-4d81-b072-d5fbc1290826.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8541dc3836044e518c6a65c867b2418faae3a5b4
--- /dev/null
+++ b/output/text/4559536e-0aa8-4d81-b072-d5fbc1290826.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis / Diagnoses: 1.: Right hemicolectomy specimen with tumor-free resection margins, under inclusion of an ulcerated, moderately differentiated adenocarcinoma (right flexure), with infiltration and penetration of the lamina muscularis propria (G2, pT2).. 2.: Rectal resectate with inclusion of a broad-based tubulovillous adenoma with mild dysplasia (synonym: low-grade intra-epithelial neoplasia) and also with free-free resection margins. A follow-up report will be made on the lymph node status. Follow-up report: A total of 18 lymph nodes of up to 0.9 cm in size in the vicinity of the tumor were dissected out of the pericolic fatty tissue in the region of the right flexure (1.) after acetone fixation. Based on microscopy, these were all tumor-free.. In conclusion, or in summary, a stage of pT2 pN0 (0/18) is thus determined for the adenocarcinoma described in the right hemicolectomy specimen.. There were also no histological abnormalities in the fatty tissue on the rectal resectate.
\ No newline at end of file
diff --git a/output/text/456865ba-ebba-4fd5-ac2f-3957ea7754b7.txt b/output/text/456865ba-ebba-4fd5-ac2f-3957ea7754b7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e6a8f3f4079f149778bb0ca8c70a8c215adc5bd1
--- /dev/null
+++ b/output/text/456865ba-ebba-4fd5-ac2f-3957ea7754b7.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Jcs-0 -3 Caraiom nfiltnatig duct Nrs 35os/3 Site: srust, N0s e50.9 3/28)) DIAQNOSIS: 16 H&E STAINED*SLIDES prEvIOUs RepORtSi Left mastectomys : RY Z.Q BY. ZhQ CM. : : POORLY DIFFERENTIATeD InISRMEDIAIE NUCLEAB SRADE EXIENDINg TQ HIIHIN L MM OE LINE OE RESECTION AnD mAsSIye yAScULAR PERmEATion. INcLudIng NiRPLE FIBrocysTic Changes METASTATIC TuMQR WITH CAPSULAR AND ExTRAcAPSUL AR EXTENSiQN UUID: 4F943D12-E769-45F3-86BE-75193786DD4E TCGA-BH-A208-01A-PR Redacted
\ No newline at end of file
diff --git a/output/text/456c5303-6a53-4ab3-96aa-56ec9bab2c1f.txt b/output/text/456c5303-6a53-4ab3-96aa-56ec9bab2c1f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..aee6fa1e91a878ac68078baf0c52ba8af1f260ff
--- /dev/null
+++ b/output/text/456c5303-6a53-4ab3-96aa-56ec9bab2c1f.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TCD3  UUID:66636026-A914-4E12-85D8-AAF98739E120 8q6O/3 ted C64 9 w|13|14 Papillary Renal Cell Carcinoma, Type I, with infiltration of the peri-renal fat layer. Maximum dimension: 7.5 cm. Surgical margins, vasculature and Ureter are free of tumor. Stage: pT3a, pNX, L0, V0, R0 Grade: GII ICD-0-Code: 8260/3 Lateralrhy
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diff --git a/output/text/45920db2-5505-4f97-aef3-243f69a04bb1.txt b/output/text/45920db2-5505-4f97-aef3-243f69a04bb1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a7499afb3ce3c84d27996ccc161b487ba34d65df
--- /dev/null
+++ b/output/text/45920db2-5505-4f97-aef3-243f69a04bb1.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+DIAGNOSIS A) LOWER JUGULAR LYMPH NODE: Lymph node, no tumor. TOTAL LARYNGECTOMY, PARTIAL PHARYNGECTOMY, AND BILATERAL NECK DISSECTION WITH SUBTOTAL THYROIDECTOMY: SQUAMOUS CARCINOMA GRADE 3 INVOLVING LEFT VOCAL CORD, LEFT VENTRICLE, AND LEFT SUPRAGLOTTIC AREA (THICKNESS OF THE TUMOR 2.O CM). Margins of resection free of tumor. Nodular goiter right thyroid. Twenty-five right cervical nodes. Thirty-nine left cervical lymph nodes, no tumor. Specimen designated"B1 to B13", mucosal margins of resection free of tumor. GROSSDESCRIPTION (A) LOwER JUGULAR LYMPH NODE - Two tan lymph nodes (the largest of which measures up to 0.6 cm in greatest dimension) SECTION CODE:A,twOlymph nodes. (B)TOTAL LARYNGECTOMY, PARTIAL PHARYNGEC MY AND BILATERAL NECK DISSECTION WITH suBToTAL THyroIDEcroMy - A total laryngectomy with bilateral neck dissection with overall measurements of 15.0 x 15.0 x 5.5 cm._The laryngeal component is measuring 9.0 x 6.0 x 3.5 cm. On the left supraglottic area there is a fungating ulcerated and soft mass measuring 3.5 x 3.5 x 2.0 cm. The tumor involves the Teft vocal cord and supraglottic area with impingement on the. midline without involvement of the right glottic area. Tumor extends 2.5 cm in the supraglottic region. No gross involvement of the soft tissue is identified and the mucosa surrounding the tumor appears unremarkable. There is an additional nodule in the left pyriform sinus.. .There is no connection between this nodule and the main tumor. The nodule is light-tan, slightly raised and measuring1.5cm x1.0x0.4 cm. SEcrion coDe: The specimen is submitted as follows: Mucosal margins for frozen section as follows: B, posterior cricoid; B2, inferior left pyriform margin; B3, inferior lateral left pyriform; B4, left ateral pyriform margin;. B5, left superolateral pyriform; B6, left superior pyriform; B7 left lateral. mollecula B8midline and right mollecula B9, right mollecula; B10, right superior pyriform; B11,right lateral pyriform; B12, right inferior pyriform; B13, right post cricoid.The tumoris submitted entirely from right to left and the block code is B14, right transglottic; B15, right supraglottic mucosa; B16-B31,sequential sectionsfrom midline to the left pyriform sinus tumor and Page 1 of 2 History Case Pathology Report History Case Pathology File under: Pathology
+
+--- Page 2 ---
+necrosis; B32, B33, from the small nodule in the left pyriform sinus; B34,. right thyroid lobe with a smal7 nodule; B35, section of the left colloid nodule;B36 five superior right neck 1ymph nodesB373 possible right superior neck 1ymph nodesB384 superior right 7ymph nodes B39,true right inferior 1ymph nodeB40-B411 right inferior 1ymph nodeB423 right inferior 1ymph nodesB43,4 right inferior 1ymph nodes;B44,2 right inferior 1ymph nodesB4521eft superior1ymph nodesB46B47 11eft superionlymph nodeB483 1eftsuperior Tymph nodesB496 left superior 1ymph nodesB50, 41eft inferior 1ymph noesB5141eft inferior 1ymph nodesB524 left inferior 1ymph nodesB534 left inferior 1ymph nodes:B54 '3 left inferior Tymph nodesB553 1eft inferior 1ymph nodes. *FS/DX:SQUAMOUS MUCOSA WITH UNDERLYING FIBROADIPOSE TISSUE AND FIBROMUSCULAR TISSUE, NO EVIDENCE OF MALIGNANCY. SNOMED CODES M-80703 T-24455 Page 2 of 2 History Case Pathology Report History  Case Pathology File under: Pathology
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diff --git a/output/text/459a549c-5a56-4189-9cef-6ef3fe08d20b.txt b/output/text/459a549c-5a56-4189-9cef-6ef3fe08d20b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1cd50177ae7e0ec15066d431c6d69da91aec755e
--- /dev/null
+++ b/output/text/459a549c-5a56-4189-9cef-6ef3fe08d20b.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Icdo-3 Carenona renal ce0l CAsnephobe 83/73 SURGICAL PATHOLOGY Sate DKeney Ns5 Case Number : JCb4.9 Diagnosis: Kidney, left, robotic partial nephrectomy Histologic tumor type/subtype: Renal cell carcinoma, chromophobe type, eosinophilic variant. This diagnosis is supported by immunostains which show the following results: CK7: focally positive Vimentin: negative. cD15: negative UUID:0394D68B-20D1-4765-9993-2AF8A8572CAA TCGA-UW-A72M-01A-PR Sarcomatoid features: Not identified Histologic grade (if applicable): 2 Tumor size (greatest dimension): 3.5 cm Tumor focality: Unifocal Extent of tumor invasion (if present specify if macroscopic or microscopic): Capsular invasion/perirenal adipose tissue: Not identified Gerota' s fascia: Not identified. Renal sinus: Not present in specimen Major veins (renal vein or segmental branches, Ivc): Not present in specimen Ureter: Not present in specimen Venous (large vessel): Not identified. Lymphatic (small vessel): Not identified Histologic assessment of surgical margins: Renal parenchymal margin (partial nephrectomy only): Free of tumor Renal capsular margin (partial nephrectomy only): Free of tumor Paranephric adipose tissue margin (partial nephrectomy only): Free of tumor Adrenal gland: Not present in specimen Lymph nodes: None submitted Other significant findings: None
+
+--- Page 2 ---
+AJCc Staging: pT1a pNx This staging information is based on information available at the time of this report, and is subject to change pending clinical review and additional information. Clinical History: -year-old male with left renal mass. Gross Description: Specimen fixation: formalin Type of specimen: robotic partial nephrectomy Side of specimen: left Size and weight of specimen: 4.5 x 4.5 x 4.0 cm, 36 grams Orientation: Perinephric fat=blue, parenchymal margin=black Presence/absence of adrenal gland: absent Tumor site: cortex Tumor description: well circumscribed, smooth, pink/tan and rubbery with a central stellate gray/white fibrosis. Tumor size: 3.5 x 3.4 x 3.2 cm Presence/absence of multicentricity: absent Confinement/non-confinement to the kidney: the mass is confined to the kidney, bulges the capsule Extent of invasion: Perirenal adipose tissue: does not involve Gerota' s fascia: does not involve Renal vein: n/a
+
+--- Page 3 ---
+Ureter: n/a Renal Sinus: n/a Pelvicaliceal: n/a Adrenal: n/a. Other organs: n/a Surgical margins: Perirenal adipose tissue: negative 0.2 cm from the perirenal adipose tissue margin Renal vein: n/a Renal artery: n/a Ureter: n/a Parenchymal margin: mass grossly abuts the parenchymal margin Description of kidney away from tumor: red/brown and smooth Hilar lymph nodes: n/a Other significant findings: none Tissue submitted for : Tumor given to Digital picture: no Block summary: A1,A2 perpendicular of mass abutting the parenchymal margin A3,A4  - mass abutting the capsule with overlying perinephric fat h n[3o[l3
\ No newline at end of file
diff --git a/output/text/45a72a5d-00f2-41a3-9f69-eeb3d3e64cb4.txt b/output/text/45a72a5d-00f2-41a3-9f69-eeb3d3e64cb4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..494a63e66b36c0ce1dceb4ae913476f03c5c05b3
--- /dev/null
+++ b/output/text/45a72a5d-00f2-41a3-9f69-eeb3d3e64cb4.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UUID:64478CA8-EA92-4334-AC37-3A0906057203 TCGA-DK-AA6S-01A-PR Redacted SURGICAL PATHOLOGY REPORT Reformatted Report Patient Name: Accession #: Med. Rec. #: Date of Procedure: DOB: Location: Date of Receipt:  Urology Gender: M Service: Date of Report: Ref. Physician: Account #: Patient Address: Billing Type: Additional Copy to: Ref. Source: LD-D3 Other Related Data: Billing Type: Financial Number: Careunorrie, itrensitionel cese NS s 8/Q/3 Clinical Diagnosis & History: Site: Rloddery latros woll Bladder cancer. Co7.2 Specimens Submitted: QsJ y/3c/y 1: SP: Bladder,prostate,urethra,urachus,rt.pelvic I.n 2: SP: Lt. vas deferens 3: SP: Lt. iliac lymph nodes 4: SP: Lt. obturator nodes 5: SP: Lt. peri-vesicle lympn nodes 6: SP: Lt. distal ureter 7: SP: Rt. distal ureter DIAGNOSIS: 1) BLADDER, AND PROSTATE; CYSTECTOMY WITH PROSTATECTOMY: TRANSITIONAL CELL CARCINOMA, POORLY DIFFERENTIATED/UNDIFFERENTIATED. - MULTICENTRIC FOCI OF INVASIVE CARCINOMA ARE PRESENT. - NO IN SITU CARCINOMA IS IDENTIFIED. - THE TUMOR INVADES INTO THE PERIVESICAL SOFT TISSUES (pT3b).  THE TUMOR DOES NOT EXTEND BEYOND THE BLADDER. - VASCULAR INVASION IS PRESENT. PERINEURIAL INVASION IS PRESENT. ALL SURGICAL MARGINS ARE FREE OF TUMOR.  THE NON-NEOPLASTIC MUCOSA SHOWS THE FOLLOWING ABNORMALITY(IES) : CHRONIC CYSTITIS, FOREIGN BODY REACTION AND PROLIFERATIVE CYSTITIS (BRUNN'S NESTS, CYSTITIS CYSTICA,) CYSTITIS GLANDULARIS) .  THE PROSTATE SHOWS NODULAR HYPERPLASIA, AND HIGH GRADES PROSTATIC INTRAEPITHELIAL NEOPLASIA (PIN) WITH ASSOCIATED ATYPICAL SMALL ACINAR PROLIFERATION.  THE SEMINAL VESICLES ARE UNREMARKABLE - THE LYMPH NODE STATUS IS AS FOLLOWS (EXPRESSED AS THE) NUMBER OF METASTATIC NODES IN RELATION TO THE TOTAL NUMBER OF NODES EXAMINED) : FOUR NEGATIVE PERIVASCULAR LYMPH NODES (0/4). 2) VAS DEFERENS, LEFT; EXCISION: -NEGATIVE VAS DEFERENS. Page 1 of 5
+
+--- Page 2 ---
+SURGICAL PATHOLOgY REPORT 3) LYMPH NODES, LEFT ILIAC; EXCISION: - FIVE NEGATIVE LYMPH NODES (O/5). 4) LYMPH NODE, LEFT OBTURATOR; EXCISION: - EIGHT NEGATIVE LYMPH NODES (O/8). 5) LYMPH NODE, LEFT PERI-VESICLE; EXCISION: - TWO NEGATIVE LYMPH NODES. 6) URETER, LEFT DISTAL; EXCISION: - NEGATIVE URETER. 7) URETER, RIGHT DISTAL; EXCISION: - NEGATIVE URETER. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. *** Report Electronically Signed Out *** Gross Description: 1A) The specimen is received fresh, labeled "Bladder, prostate, urethra, urachus, right pelvic lymph nodes, right perivesicle. lymph nodes". It consists of a bladder, measuring 5.0 x 4.0 x 2.0 cm with attached prostate and urethra. The urethra measures 4.0 x 2.5 x 1.8 cm, showing a red-tan, hemorrhagic, edematous, mucosal surface. The posterior wall of the bladder is partially covered with pink-tan, smooth, shiny peritoneum, measuring 6.0 x. 5.0 cm. The superoanterior margin of the specimen is attached with yellow-tan, lobulated fibroadipose tissue, containing lymph nodes, measuring 9.0 x 5.0 x 3.5 cm. Right and left ureters are identified. The right ureter measures 3.4 cm in length and approximately 0.4 cm in diameter. The right ureter is probed, showing a pink-tan, smooth, shiny inner surface. The left ureter measures 3.6 cm in length and is dilated to approximately 0.9 cm in diameter. The left ureter is probe-patent and contains clear fluid. The surgical margin is entirely inked. The bladder is opened anteriorly, showing an irregular ulcerative, hemorrhagic, firm tumor mass which occupies the left bladder wall and one of the posterior wall includes a right and left orifice, trigone and proximal urethral areas. The tumor mass measures 4.7 x 4.0 x 2.0 cm, protruding through the left bladder wall and extending to paravesical fatty tissue. The prostate is separated from the bladder and will be processed later. Representative sections are submitted. Summary of Sections: - Urethral margin RU  - Right ureter LU - Left ureter Page 2 of 5
+
+--- Page 3 ---
+SURGICAL PATHOLOGY REPORT RO - Right orifice LO - Left orifice TG - Trigone AW - Anterior wall PW - Posterior wall D - Dome RW - Right wall. LW - Left wall T - Tumor RLN - Right pelvic lymph node. LLN - Left pelvic lymph node 1B) The specimen is received fresh, labeled "Prostate and. seminal vesicles". It consists of a radical prostatectomy specimen which includes prostate, seminal vesicles, and portions of right and left vasa deferentia. The specimen weighs 25 grams. The prostate measures 3.5 cm from apex to base, 3.0 cm. transversely, and 2.8 cm from anterior to posterior. The right seminal vesicle measures 3.5 x 1.6 x 0.9 cm and the left seminal vesicle measures 3.3 x 1.6 x 0.8 cm. The external surface of the prostate is smooth. The prostate is serially sectioned from apex to base at approximately 3 mm intervals. The peripheral zone show(s) no abnormalities. The periurethral (transitional zone) shows no abnormalities. 100% of the prostatic tissue is. submitted. Summary of sections: RA - right apical margin LA - left apical margin BN - bladder neck margin RSV - right vas deferens and seminal vesicle LSV  - left vas deferens and seminal vesicle A-F - serial sections of prostate from apex to base. 2)  The specimen is received in formalin, labeled "Left vas. deferens". It consists of two fragments of tubular rubbery tissue, partially surrounded by yellow-tan fibroadipose tissue, measuring 1.4 cm in length, 0.3 cm in diameter and 2.0 cm in length and 0.4 cm in diameter. Representative sections are submitted. Summary of Sections: SM - Surgical margin RS - Representative sections 3) The specimen is received in formalin, labeled "Left iliac. lymph nodes". It consists of an irregular piece of yellow-tan fibroadipose tissue, measuring 3.0 x 2.0 x 1.0 cm which contains several lymph nodes. The specimen is submitted entirely.. Summary of Sections: U - Undesignated. Page 3 of 5
+
+--- Page 4 ---
+SURGICAL pAThOLOGy REPORt 4)  The specimen is received in formalin, labeled "Left obturator nodes". It consists of an irregular piece of yellow- tan fibroadipose tissue, measuring 4.0 x 3.5 x 1.4 cm, containing several lymph nodes. The specimen is submitted entirely.. Summary of Sections: U - Undesignated 5) The specimen is received in formalin, labeled "Left perivesicle lymph nodes". It consists of an irregular piece of yellow-tan fibroadipose tissue, measuring 2.8 x 2.2 x 1.1 cm. The specimen is submitted entirely. Summary of Sections: U - Undesignated 6) The specimen is received in formalin, labeled "Left distal. ureter". It consists of a fragment of ureter measuring 0.4 cm in length and 0.9 cm in diameter. The specimen is submitted entirely. Summary of Sections: U - Undesignated. 7) The specimen is received in formalin, labeled sRight distal. ureter". It consists of a portion of ureter, surrounded by. yellow-tan fibroadipose tissue, measuring 2.7 cm in length and 0.9 cm in diameter.  Representative sections are submitted. Summary of Sections: SM  - Surgical margin RS  - Representative sections Summary of Sections: Part Sect. SiteBlocks Pieces Al1 1 A 1 1 N AW 1 1 B 1 1 c 1 1 D 2 2 1 1 F 1 1 LLN 11 LO 1 1 LSV 1 LU 1 1 LW 1 1 PW 1 1 RLN 8 RO 1 1 RSV 1 - Page 4 of 5
+
+--- Page 5 ---
+SURGICAL PATHOLOGY REPORT RU 1 1 RW 1 1 T 3 3 TG 1 UM 1 1 2 RS 1 2 N SM 4 3 U 3 Y 4 M Y 5 o U 2 m Y U 1 1 >z 7 RS 1 1 SM 1 2 18/1y Page 5 of 5 END OF REPORT
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diff --git a/output/text/45dadf2a-1b96-4154-a0a0-dfb43992af0a.txt b/output/text/45dadf2a-1b96-4154-a0a0-dfb43992af0a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9c8866d464d0f27f3428c2f0ed2b8b075a8f78b8
--- /dev/null
+++ b/output/text/45dadf2a-1b96-4154-a0a0-dfb43992af0a.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis: Resected colon (sigma) with tumor-free oral and aboral resection margins, including a hyperplastic polyp and several tubular adenoma with mild to moderate dysplasia (synonymously: mild intraepithelial neoplasia) and with an ulcerated, moderately differentiated adenocarcinoma with infiltration of the perimuscular adipose tissue and with several lymph node metastases in the region (G2, pT3, L1, V0, local R0, pN2, 5/25).
\ No newline at end of file
diff --git a/output/text/45eb1861-80a7-46ba-ab81-ed549e13ee67.txt b/output/text/45eb1861-80a7-46ba-ab81-ed549e13ee67.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9d8e58399742e25c42a90f386ce09f7cd0c9535e
--- /dev/null
+++ b/output/text/45eb1861-80a7-46ba-ab81-ed549e13ee67.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+TSS: tcb-Oi3 Carcinoma, mn filtrstng ductl nos 8500/3 Pnh Sits: brut, yppw ontw gusdret c50.4 SPECIMENS: A. LEFT MODIFIED RADICAL MASTECTOMY B. LEFT AXILLARY CONTENTS LEVELS 1 AND 2 CQLF Sih: brwstN1s cso.q SPECIMEN(S): A. LEFT MODIFIED RADICAL MASTECTOMY B. LEFT AXILLARY CONTENTS LEVELS 1 AND 2 INTRAOPERATIVE CONSULTATION DIAGNOSIS: Gross Exam A Left breast, modified radical mastectomy: Tumor is grossly 0.1 cm for posterior margin and >0.5 cm from other margins. By Dr., called to Dr. at GROSS DESCRIPTION: A. LEFT MODIFIED RADICAL MASTECTOMY Received fresh labeled with the patient name designated "ieft modified radical mastectomy", is a resected mastectomy specimen weighing 203 grams and measuring 19.6 x 7.5 x 5.8 cm. Specimen is received with orientation, a suture indicating the axiliary tail. The ellipse of beige-tan skin measures 15.8 x 7.2 cm. The light brown areola measures 2.5 cm in diameter. The everted nipple measures 1.3 cm in diameter. The surface of the skin shows two firm masses, the larger measuring 2.5 x 2, the smaller measuring 0.6 x 0.6 cm. A large mass is palpated beneath the two lesions. The deep posterior margin is inked black, the anterior is inked orange. The specimen is serially sectioned from lateral to mediai. Cut section shows a beige-tan firm, slightly necrotic mass which demonstrates a thick amber colored mucoid fluid. The mass lies just beneath the deep margin at a distance of 0.1 cm. The mass occupies the upper outer quadrant into the axillary tail. The mass measures 6.8 x 6.5 x 3.5 cm. The remainder of the specimen shows dark yellow lobulated adipose tissue with focal areas of white firm, fibrous parenchyma. A portion of the specimen is submitted for tissue procurement. Gross photographs are taken. Representative sections are submitted as follows: A1-A2:  sections of lesion and closest margin, posterior, and skin. A3-A4:  one full thickness section from skin to deep margin with lesion A5-A11: sections of lesion from upper-outer quadrant through mid portion A12-A13: sections of lower-outer quadrant A14-A15: representative sections lower-inner quadrant A16-A17: representative sections upper-inner quadrant A18-A19: sections of nipple. A20-A24:  axillary lymph nodes, 2 sections from each B. LEFT AXILLARY CONTENTS LEVELS 1&2 Received fresh are multiple tan-pink fragments of fibrofatty tissue aggregating to 6.0 x 3.0 x 2.0 cm. Dissection reveals 13 possible lymph nodes ranging from 0.1 x 0.1 x 0.1 cm to 3.5 x 2.5 x 2.0 cm. Section code: B1: Three possible lymph nodes B2: Four possible lymph nodes B3: Two possible lymph nodes UUID:6CC4E6EF-6664-448E-933E-FFA9117C7ABF TCGA-E2-A1LK-01A-PR Redacted B4: Two possible lymph nodes B5: One lymph node serially sectioned B6-B10: Largest lymph node serially sectioned. DIAGNOSIS: A. BREAST, LEFT, MODIFIED RADICAL MASTECTOMY: - MULTIFOCAL, INVASIVE, DUCTAL.CARCINOMA, SBR GRADE 3 WITH NECROSIS, LARGEST FOCUS MEASURES 6.8-CM, INVOLVING LATERAL HALF OF THE BREAST WITH EXTENSION TO SUPERFICIAL DERMIS - SURGICAL RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA - LYMPHOVASCULAR AND PERINEURAL INVASIONS IDENTIFIED - METASTATIC CARCINOMA TO TWO OF THREE LYMPH NODES (2/3), WITH EXTRANODAL EXTENSION, LARGEST MEASURING 2.8-CM - SEE SYNOPTIC REPORT. B. LYMPH NODES, LEFT AXILLARY CONTENTS, LEVELS 1 AND 2, RESECTION: - METASTATIC CARCINOMA TO NINE OF TWELVE LYMPH NODES (9/12), WITH EXTRANODAL EXTENSION, LARGEST MEASURING 3.5-CM.
+
+--- Page 2 ---
+TSS: SYNOPTIC REPORT - BREAST Specimen Type: Mastectomy Needle Localization:  No Laterality: Left Invasive tumor: Present Multifocality: Yes WHO CLASSIFICATION Invasive ductal carcinoma, NOs 8500/3 Tumor size: 6.8cm Tumor site:  Upper outer quadrant Lower outer quadrant Margins:  Negative Distance from closest margin:  0.4cm deep Tubular score: 3 Nuclear grade: Mitotic score:3 3  Modified Scarff Bloom Richardson Grade: Necrosis: Present Vascular/Lymphatic Invasion:  Present Extent: focal None Lobular neoplasia: Axillary dissection Lymph nodes: Lymph node status:  Positive 11 / 15 Extranodal extension Non-neoplastic areas: fibroadenoma DCIS not present ER/PR/HER2 Results Performed on Case: ER: Negative PR: Negative HER2: Negative by FISH Pathological staging (pTN): pT 3 N 3a CLINICAL HISTORY: year old female with large left breast IDC/ulcerating -- now for modified radical mastectomy (left). PRE-OPERATIVE DIAGNOSIS: Left breast carcinoma. Gross Dictation: Pathologist, Microscopic/Diagnostic Dictation: Pathologist. Finai Review: Pathologist Microscopic/Diagnostic Dictation: Patholoaist, Final Review.., Pathologist. Final: Pathologist,
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diff --git a/output/text/46126923-d388-4c3d-b968-2347a619fd56.txt b/output/text/46126923-d388-4c3d-b968-2347a619fd56.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c67a7c228feca62c25d4e988be62a10a8b3fbbe1
--- /dev/null
+++ b/output/text/46126923-d388-4c3d-b968-2347a619fd56.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Path (First Tumor) Tumor Site: Sigmoid Distal Date of Cancer Sample Procurement: Histology: Adenocarcinoma Description of other histology: Grade: Moderately Differentiated C Yes Mucinous: 6 No  Yes r Unknown (Focal) r Yes Signet Ring Feature:  No r Yes  Unknown (Focal) Histologic Heterogeneity: 6 No ( Yes r Unknown Host Response: Lymphoid Aggregates Crohn's like reaction ( None 6 Yes C Unknown Plasma cell rich stroma r No  Yes r Unknown  Expansile Growth Pattern:  Expansile  Invasive r Unknown and Invasive Inflammatory Bowel Disease 6 No ( Yes  Unknown Angiolymphatic Invasion: C No  Yes C Unknown Mutator Phenotype:  No  Yes C Unknown Number of Slides 2 C Yes Garland Necrosis present: C No  Yes r Unknown (Focal) TIL Cells / HPF To Pathologist Comment: 1co-0-3 idens cuicii omay 7 Nos 8140/3 Site : signoiL csfin C18.7 UUID:E6C435F8-1238-4113-A152-C7AF7620E748 Redacted hr 5|3/11 TCGA-DM-A28F-01A-PR
\ No newline at end of file
diff --git a/output/text/4650d1b2-528a-484e-a659-6d71cb191fac.txt b/output/text/4650d1b2-528a-484e-a659-6d71cb191fac.txt
new file mode 100644
index 0000000000000000000000000000000000000000..044d7a31671d5b1779c2c2aaa339e02cc2dc1bc0
--- /dev/null
+++ b/output/text/4650d1b2-528a-484e-a659-6d71cb191fac.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UUID: B8914E0E-6446-4467-9BB3-08593BFBEFCD TCGA-DK-A6B2-01A-PR Redacted SURGICAL PATHOLOGY REPORT Patient Name: Accession #: Med. Rec. #: Date of Procedure: DOB: Location: Age: Date of Receipt: Gender: Service:  Urology Date of Report: Ref. Physician: Account #: Patient Address: Billing Type: INPATIENT Additional Copy to: Ref. Source: IcD-O-3 Clinical Diagnosis & History: 8120/3 T2 UCB. Specimens Submitted: C674 1: Bladder, prostate, seminal vesicles, peri-vesicle lymph nodes, radical cystoprostatectomy path 2: Right distal pelvic lymph nodes, resection 3: Left distal pelvic lymph nodes, resection. 4: Right distal ureter, excision y 4|1813 5: Left distal ureter, excision DIAGNOSIS:  Bladder, prostate, seminal vesicles, peri-vesicle lymph nodes, radical cystoprostatectomy: Tumor Type: Invasive urothelial carcinoma, NOS Histologic Grade: High grade Pattern of growth of the Non-Invasive component:. Flat (in situ carcinoma) Pattern of growth of the Invasive component:  Infiltrating Tumor Multicentricity: Identified Bladder Local Invasion: Perivesical soft tissues Extravesical Tumor Extension: Right ureter involved Left ureter involved. Urethra involved  Periurethral prostatic ducts involved Prostatic stroma involved Vascular Invasion:  Identified extensive  Perineural Invasion: Identified Surgical Margins: Tumor present at right ureteral margin. Tumor present at left ureteral margin. Tumor present at urethral margin For actual ureteral margins, please see parts 4 and 5 Non-Neoplastic Mucosa: Exhibiting ulceration Prostate: Other Extensively involved by urothelial carcinoma Seminal Vesicles: Other Involved by invasive urothelial carcinoma, bilateral. Page 1 of 5
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT Perivesical Lymph Nodes:. Not identified The Pathologic Stage is (AJCC 2002):  pT3 (Invasion of perivesicle soft tissue) PR2 (Periprostatic or periseminal vesicle soft tissue invasion). 2.  Right distal pelvic lymph nodes, resection: Lymph Node Dissection: Metastatic urothelial carcinoma Number of lymph nodes examined: 2 Number of lymph nodes with metastatic disease: 1 Size of the largest lymph node involved by tumor: 1.8cm.. Size of the largest metastatic focus : 0.9 cm. Ettranddal extension is identified Left di$tal pelvic lymph nodes, resection: Lymph Node Dissection:  Benign fibroadipose tissue. Right distal ureter: - Urothelial carcinoma in situ - Resection margin involved by carcinoma in situ. 5. Left distal ureter: - Urothelial carcinoma in situ - Resection margin involved by carcinoma in situ. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE Gross Description: 1). The specimen is received fresh labeled, "Bladder, prostate, seminal vesicles, peri-vesicle lymph node". It consists of a bladder with attached prostate and adnexa measuring 19.0 cm from superior to inferior, 11.0 cm laterally and 5.0 cm from anterior to. posterior. The anterior aspect of the bladder is inked blue and the posterior black. The prostatic urethral margin is shaved and submitted. The bladder is opened along the anterior midline to reveal hemorrhagic, ulcerated, indurated, necrotic tumor measuring 5.0 x 4.8 x 1.8 cm which is grossly situated within the ieft and right posterior walls. The tumor grossly invoives both the left and. right ureteral orifices.  Both ureters are probed patent measuring up to 0.2 cm in maximum diameter. The lesion is sectioned to. reveal white-pink cut surface with invades the underlying fat. Possible extension to the inked fat is grossly identified. The remaining bladder mucosa is pink-tan with the normal folds. Two ovoid lesions measuring 0.6 x 0.4 cm are identified at the dome and right posterior wall. Discrete perivesical lymph nodes are grossly not identified.  The prostate is serially sectioned to reveal white-tan. prostatic parenchyma with multiple yellow foci and white fluid filled cysts identified. A gold thread-like material is identified within the prostate.  Representative sections are submitted sections from each prostatic quadrant and transition zone. TPS is submitted, gross photograph taken. Summary of sections: UTHM - urethral margin RUM - right ureter margin LUM - left ureter margin Page 2 of 5
+
+--- Page 3 ---
+SURGICAL PATHOLOGy REPORt T - tumor DL-dome lesion WL--wall lesion RUO - right ureter orifice LUO - left ureter orifice LP - left posterior wall LA - left anterior wall  RP - right posterior wall RA- right anterior wall TRI -- trigone DOM - dome F - perivesical fat RSV - right seminal vesicle. LSV - left seminal vesicle RAP - right apex prostate LAP - left apex prostate RAM - right anterior mid prostate RPM - right posterior mid prostate LAM - left anterior mid prostate LPM - left posterior mid prostate RAB - right anterior base prostate. RPB - right posterior base prostatee LAB - left anterior base prostate. LPB - left posterior base prostate 2). The specimen is received in formalin, labeled "Right distal pelvic lymph nodes" and consists of three pink tan firm , fatty lymph  nodes ranging from 1.5 to 3.2 cm in greatest dimension.  All identified lymph nodes are submitted.. Summary of sections: LN - lymph node BL1 - bisected lymph node #1 BL2 -- bisected lymph node #2. 3). The specimen is received in formalin, labeled "Left distal pelvic lymph nodes" and consists of a portion of yellow tan adipose tissue measuring 4 x 1 x 1 cm. No palpable lymph node is identified. Entirely submitted.. Summary of sections: U - undesignated 4) The specimen is received in formalin, labeled "right distal ureter- unclipped end is margin" and consists of a gray-tan segment of ureter measuring 0.7 cm in length and 0.4 cm in diameter.  A clip is present at one end which is inked black. The opposite end, identified as the margin, is inked blue. The specimen is serially sectioned and totally submitted.. Summary of sections: M - margin (blue ink) SS - serial sections 5) The specimen is received in formalin, labeled "left distal ureter- unclipped end is margin" and consists of a gray-tan segment of ureter measuring 2.3 cm in length and 0.4 cm in diameter.  A clip is present at one end which is inked black.  The opposite end, identified as the margin, is inked blue. The specimen is serially sectioned and totally submitted.. Summary of sections:  Page 3 of 5
+
+--- Page 4 ---
+SURGiCAL PATHOLOgy REPORt M - margin (blue ink) SS - serial sections Summary of Sections:  Part 1:  Bladder, prostate, seminal vesicles, peri-vesicle lymph nodes, radical cystoprostatectomy PCs Block Sect. Site DL 2 1 DOM 2 1 F 1 1 1 LA 2 1 LAB 1 1 LAM 1 1 LAP 1 1 LP 2 1 LPB 1 1 LPM 1 1 LSV 1 LUM 1 1 1 LUO 1 1 RA 2 1 RAB 1 RAM 1 1 RAP 1 1 1 RP 2 RPB 1 1 RPM 1 RSV 1 1 1 RUM 1 RUO 1 1 7 T 7 1 TRI 2 1 UTHM 1 1 WL 2 Part 2:Right distal pelvic lymph nodes, resection Block Sect. Site PCs 22 BL1 2 BL2 2 1 LN 1 Part 3: Left distal pelvic lymph nodes, resection Block Sect. Site PCs 3 3 Part 4:Right distal ureter, excision Sect. Site pCs Block m 1 1 ss 2 Part 5:Left distal ureter, excision Block Sect. Site PCs 1 M 1 Page 4 of 5
+
+--- Page 5 ---
+SURGICAL PATHOLOGY REPORT 2 ss 4 Page 5 of 5 END OF REPORT
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diff --git a/output/text/46824ca1-07cc-43f2-8d45-32c65033bae5.txt b/output/text/46824ca1-07cc-43f2-8d45-32c65033bae5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8a52d78ce0581a0f7596d1a60c0453f9f7298baa
--- /dev/null
+++ b/output/text/46824ca1-07cc-43f2-8d45-32c65033bae5.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Results SURGICAL PATHOLOGY Patient Info Patient Name  Sex DOB Results UUID: 8B8301E6-D39D-43AA-A7E7-83425DFD0E74 TCGA-IA-A83S-01A-PR Redacted Specimen #: Physician: FINAL DIAGNOSIS LEFT KIDNEY, PARTIAL NEPHRECTOMY - RENAL CELL CARCINOMA, PAPILLARY TYPE (3.8 CM IN GREATEST DIMENSION), FURHMAN GRADE II/IV. -THE TUMOR INVADES INTO THE RENAL CAPSULE.  VASCULAR INVASION IS NOT IDENTIFIED. - SOFT TISSUE AND PARENCHYMAL MARGINS OF RESECTION ARE NEGATIVE. ***Electronic Signature*** IcDO-3 SPECIMEN SUBMITTED Careinond, paypillsry ^enol Ae0 A: LEFT PARTIAL NEPHRECTOMY 8Q60/3 Sub OKidnuyN0S CLINICAL DATA C64.9 LEFT RENAL MASS ht ) 1017/13 GROSS DESCRIPTION A. Received fresh is a partial nephrectomy specimen measuring 8.5 x 6 x 4.5 cm and weighing 63 grams. The parenchymal margin of resection is inked with black ink, as well as the soft tissue (adipose tissue) line of resection. Multiple cross sections reveal a round, soft, red-brown lesion measuring 3.8 x 3 x 3.5 cm.  No foci of necrosis are grossly identified.. This lesion is located 0.9 cm away from the closest parenchymal margin of resection and is bulging through the capsule but is not invading into the adjacent adipose tissue. Representative sections are submitted as follows in formalin: #1 parenchymal margin; #2 soft tissue margin; #3 & #4 representative section of the mass.. Patient ID #: DOB: Date of Report: Date of Procedure: Date of Receipt: Submitted by: Location: Lab and Collection SURGICAL PATHOLOGY  Lon Page l of 2
+
+--- Page 2 ---
+Result History SURGICAL PATHOLOGY   on Result Information Result Nate and Time Status Provider Status Final result Ordered Status: This result is currently not released to Display Full Result Report. Display Order Report hj jo/3/13 x Page 2 of 2
+
+--- Page 3 ---
+Page I of 1 TCGA Pathologic Diagnosis Discrepancy Form 4.05  Study Subject Person ID: N/A ID: Study/Site: TCGA Kidney renal papillary cell carcinoma - <idney renal papillary cell  Age: N/A! carcinoma) Event:  PathDiscrepancy Date of  Birth: Interviewer: Sex: V  Tumor Identifier Provided on Initial Case  Provide the tumor identifier documented on the initial case quality Quality Control Form control form for this case. Pathologic Diagnosis Provided  Renal cell Provide the diagnosis/ histologic subtype(s) documented on the initial pathology on Initial Pathology Report carcinoma report for this case. If the histology for this case is mixed, provide all listed subtypes. Histologic features of the sample provided for papillary  Provide the histologic features selected on the TCGA Case Quality TCGA, as reflected on the CQCF type Control Form completed for this case. Discrepancy between Pathology Report and Case Quality Control Form Provide the reason for the discrepancy  confirmation of clarification of Provide a reason describing why the diagnosis on the between the pathology report and the KIRP Type II provided in initial pathology report for this case is not consistent with TCGA Case Quality Control Form discrepancy note the diagnosis selected on the TCGA Case Quality Control Form. Name of Tss Reviewing Pathologist or  Provide the name of the pathologist who reviewed this  Biorepository Director case for TCGA.
\ No newline at end of file
diff --git a/output/text/468cf329-9669-49e6-bb49-ce55f0a07781.txt b/output/text/468cf329-9669-49e6-bb49-ce55f0a07781.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1590b652c451b64ea6c2c338320c3bfdc9024842
--- /dev/null
+++ b/output/text/468cf329-9669-49e6-bb49-ce55f0a07781.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis/ Diagnoses 1. Mechanically altered liver tissue with sections of a regressively changed cyst with. partially dystrophic wall calcification.. 2. Subcapsular liver tissue with circumscribed, clearly regeneratory, nodular hyperplasia and moderate steatosis.. 3. Resected ileocolic sample with a moderately differentiated adenocarcinoma of the colorectal type, measuring max 4 cm, with infiltration of the tunica muscularis. propria up to the border of the perimuscular fatty tissue. Tumor-free local lymph. nodes. Tumor-free small and large intestine resection margins. Tumor-free. mesenteric resection margin. Complete, scarred obliteration of the appendix with a. condition following previous appendicitis. The tumor stage is: pT2, pN0 (0/23), pMX; G2, L0, V0, R
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diff --git a/output/text/46a11a5e-d4c4-4d0e-b3d2-b48db74e5ed5.txt b/output/text/46a11a5e-d4c4-4d0e-b3d2-b48db74e5ed5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..892ac0e01cc60ba02d6b6ec135ab7c75103fe4e7
--- /dev/null
+++ b/output/text/46a11a5e-d4c4-4d0e-b3d2-b48db74e5ed5.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Accession Number:. Final Report DIAGNOSIS: 1,2) TONSIL, LEFT TONSILLECTOMY: MODERATELY-DIFFERENTIATED INVASIVE SQUAMOUS CELL CARCINOMA. Electronically signed by:. CLINICAL DATA Clinical Features/Dx:  unspecified Operator: Operation:  unspecified Operative Findings: unspecified Operative Diagnosis:unspecified Tissue Submitted: 1) left tonsil, 2) left tonsil GROSS DESCRIPTION: 1) SOURCE: Tonsil, Left Received fresh labeled, "left tonsil," is a 1.2 x 1.0 x 0.3 cm aggregate of pink-tan tissue. The specimen is submitted in total.. Summary of sections: 1A, m/1. 2) SOURCE: Tonsil, Left Received fresh labeled, "left tonsil," is a 1.0 x 1.0 x 0.3 cm aggregate of pink-tan tissue. A portion of this tissue is submitted for research. as per request. The remaining tissue is filtered and submitted in total. Summary of sections: 2A, m/1. SNOMED: T-C5100,M-80703,
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diff --git a/output/text/46a2b301-8ece-4b11-9131-4e650a30ff10.txt b/output/text/46a2b301-8ece-4b11-9131-4e650a30ff10.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e7d79593ad6e6a9e1de642aa8f5afd43aa19aad0
--- /dev/null
+++ b/output/text/46a2b301-8ece-4b11-9131-4e650a30ff10.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:F35113C2-F4CC-43EC-8C52-B71B357DDA46 F-A9KQ-01A-PR Redacted 1cD-6.3 8i2013 Pathology report Site Ylaslde NoS C67.9 QJ 1/2911y Date of tumor procurement Date of report Histologic diagnosis High grade muscle invasive urothelial cell carcinoma covering most of the bladder wall. T3aG3 N0 M0 Anatomic site and laterality Bladder wall NOS Tumor size 5.5cm diameter Lymph node status A total of 18 lymph nodes all without tumor localization. h 12|o|l3 DISQUALIFIED ed:212413
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diff --git a/output/text/46d0d3da-8896-4676-a9c1-068fd1550507.txt b/output/text/46d0d3da-8896-4676-a9c1-068fd1550507.txt
new file mode 100644
index 0000000000000000000000000000000000000000..65fa07346e624d2a38aeb70c8217b0a20f904938
--- /dev/null
+++ b/output/text/46d0d3da-8896-4676-a9c1-068fd1550507.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+1cD-o-3 Carcinomo, infltratiny ductal Nos 850ofz Sitr srast, NsS e50.9 2 Clinical Case Report (For Collection of Cancerous Tissue) UUID:4C7445ED-8346-4DD7-8AFA-2E95E65364BF TCGA-C8-A1HN-01A-PR Redacted Informed Consentd I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator Signature Date Clinical Information RT ARTANAGENERAEINEORMATIONA Date of Birth (mm/dd/wy) Height Marital Status Race Temperature m 61  Single Married ' Gender Blood Pressure Weight  Divorced  Widow Heart Rate  Male Female 5 3k L22 0 SERORSKESTHISTORYOEPRESENTILENESSNA Chief Complaints: A lup inte Lej+hreaj j porinleS Symptoms: Clinical Findings: Atunwuy Was found in tta Lejfblag Performance Scale (Karnofsky Score):  100 Asymptomatic  80-90 Symptomatic but Fully Ambulatory   60-70 Symptomatic, in bed less than 50% of day  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden  20-30 Bed Ridden SAAARSSSARTIRNEURRENEMEDICATIONSOTRSWAT. Dose Route Frequency Date (mm/dd/yyy) Drug To To To To To
+
+--- Page 2 ---
+PAST MEDICAL HISTORY. Treatment Status Diagnosis/Disease/Disorder/Injury Diagnosis Date CSWS.OBGYNHISTORYCN # of Pregnancies Menopausal Status Date of First Menses Pexe o 2  Pre-menopausal # of Live Births  Peri-Menopausal Date of Last Menses 0.9 Post-menopausal Feas aId Oral ContraceptiveIUD  Hormone Replacement Birth Control:  Condom Therapy:  Other: PASSOCAEHISTORY Environmental Hazards: Occupation: Smoking History. Duration When Quit TYPE  Packs/day Current Status (yrs) (v)  yes nO Alcohoi Consumption Duration When Quit  Drinks/day Current Status TyPE (yrs) (yr)  yes NO Drug Use Duration When Quit Type Frequency Current Status  (yrs) (yr yES NO Age of Diagnosis  Diagnosis Relative AWAEABDATAWWK  Result Date Date Test Test Result CEA   Negative  Positive: HIV Negative  Positive: CA 15-3   Negative  Positive: Hep B Negative  Positive: CA 19-9  Negative  Positive: Negative  Positive: Hep C  Negative  Positive:  PSA   Negative  Positive: AFP Other: Negative  Positive: Other:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+AW  DIAGNOSTIG STUDIES Results Date Study Ultrasound X-Ray cT Endoscopy MRI  Biopsy V/ Baeask cne ESMCLINICALDIAGNOSISRM Preoperative Clinical Diagnosis Location of Suspected Involved Lymph Nodes Location of Suspected Distant Metastasis  Clinical Staging  Date of Diagnosis TgNAMO Stage: Z A Treatment Information HNRSURGICAETREATMENTONOR Procedure Date of Procedure Modihed .Badical. Mastetoms Primary Tumor Detailed Location Size Organ AReagT tumor As x /x cm Extension of Tumof Lymph Nodes  Location of Lymph Nodes # of Lymph Nodes Description Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Detailed Locatlon Size Organ Surgical Staging No. m 0 T 2. Stage: T NEOADJUVENTHERAPY(ChemoRadiation ImmunoHormonalorMolecular Frequency Date (mm/dd/yyyy) Drug/Treatment Dose Route To / To / To 1 / To / To / 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Date: Collected by: Date: Time: Preserved by: SPECIMENTYPE #Of samples provided  Blood/Serum/Plasma Slide Frozen  Paraffin Block Normal Diseased  Normal Diseased Normal Diseased Diseased  Normal 2 2 2 2 2 Time to Formalin Time to LN2 Time to LN2 min min 73 min 2 PATHOLOGICAEDESCRIPTIONP Primary Tumor Size  Extension of Tumor Distance to NAT Organ C cm BReasITenier Xx/x cm Lymph Nodes # Examined # Metastasized Location Distant Metastasis Size. Detailed Location Organ Pathologicai Staging N o mo Stage: IT pT 2 Notes: 2 (Neqzbue 3Leos `no lf
+
+--- Page 5 ---
+CONSOLIDaTED DIAGNOSTIC PATHOLOgy fORm* Microscopic Appearance: 1. Histological pattern: CELL DISTRIBUTION Diffuse + . STRUCTURAL PATTERN X Streaming Mosaic Storiform Necrosis Lymphocytic Infiltraxion X Fibrosis Palisading Vascular Invasion Cystic Degeneration Clusterized Biceding Alveolar Formation X Myxoid Change Indian File Psanmoma/Calcificationd 2. Cellular features. Sguamous +-Adenomatous + Sarcomatous + Lymphematous Squamoid Cell Glandular cell Round Cell Large Ceu Spindie Cell Cell Stratification Fibroblast Small Cetl  Keratin Secretion Osteobiast RS Cetl/RS Like Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell Pear! Gland formation Myoblast Plasma Celi Otherwise Specified: p 70% D2707r 2. Cellular Differentiation: Well Poor Nuclear Atypie: Nuckear Appesr.ace Hyperchromatism Nucleolar Prominent 4 Multinucleated Giant Celld Mitotic Activity Nuciear Grade Histological Diagnosis: 7p7tra/sg uetxl Cabsoa Z(Us. 4r-2 qmghacers:: Nejeere! STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CO
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diff --git a/output/text/46d9bcc7-0d5b-43a4-9228-2ff03d441571.txt b/output/text/46d9bcc7-0d5b-43a4-9228-2ff03d441571.txt
new file mode 100644
index 0000000000000000000000000000000000000000..efcd245955054e5c8e70ae9b0ec8e5502b33e559
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+
+--- Page 1 ---
+TeD-o-3 UUID: 48C11C04-947E-4954-9687-DF275D897F79 TCGA-DD-A4NA-01A-PR Redacted Carcinoma, hypats esllular MoS 8170|3 Site; Liver C2x.d S12/24117 REvIseD REpoRT (Revised information underlined) Addendum/Procedure included DIAGNOSIS: D. Liver, left lobe, resection: Poorly differentiated hepatocellular carcinoma forming a lobulated mass, 9.6 x 9.5. x 9.3 cm. There is extensive lymphovascular invasion including a tumor thrombus. The margins are negative for tumor by < 0.1 cm. Multiple (1 caval and 1 hilar) regional lymph nodes are negative for tumor. A. Lymph nodes, celiac artery, excision: Multiple (3) celiac artery lymph nodes are negative for tumor. B. Lymph node, hepatic artery, excision: A single (1) hepatic artery lymph node is negative for tumor. C. Lymph node, pericholedochal, excision: A single (1) pericholedochal lymph node is negative for tumor. Photographed. This final pathology report is based on the gross/macroscopic. examination and frozen section histologic evaluation of the specimen(s). ADDENDUM: In situ hybridization for albumin is positive. AMENDMENTs: (Previous Signout Date Revision Description: Removed "favor bile duct primary" from the original diagnosis.. ...Previous Diagnosis.. Liver, left lobe, resection: Poorly differentiated  hepatocellular carcinoma , favor bile duct primary, forming a lobulated mass, 9.6 x 9.5 x 9.3 cm. There is extensive lymphovascular invasion including a tumor thrombus. The margins are.  Multiple (1 caval and 1 hilar) regional lymph nodes are negative for tumor. A. Lymph nodes, celiac artery, excision: Multiple (3) celiac artery lymph nodes are negative for tumor. B. Lymph node, hepatic artery, excision: A single (1) hepatic artery lymph node is negative for tumor. C. Lymph node, pericholedochal, excision: A single (1) pericholedochal lymph node is negative for tumor. Photographed.
+
+--- Page 2 ---
+This final pathology report is based on the gross/macroscopic examination and frozen section histologic evaluation of the specimen(s). ***Signing Pathologist' AMENDMENTS : (Previous Signout Date: Revision Description: .. Special stains support hepatocellular. carcinoma for part D. Diagnosis changed to reflect this. ..Original Diagnosis..... D. Liver, left lobe, resection: Poorly differentiated adenocarcinoma, favor bile duct primary, forming a lobulated mass, 9.6 x 9.5 x 9.3 cm. There is extensive lymphovascular invasion including a tumor thrombus. The margins are negative for tumor by < 0.1 cm. Multiple (1 caval and 1 hilar) regional lymph nodes are negative for tumor. A. Lymph nodes, celiac artery, excision: Multiple (3) celiac artery lymph nodes are negative for tumor.. B. Lymph node, hepatic artery, excision: A single (1) hepatic artery lymph node is negative for tumor.. C. Lymph node, pericholedochal, excision: A single (1). pericholedochal lymph node is negative for tumor. Photographed. This final pathology report is based on the gross/macroscopic examination and frozen section histologic evaluation of the specimen(s).
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diff --git a/output/text/46fd864c-70f7-4f1f-b28c-30f361afcd55.txt b/output/text/46fd864c-70f7-4f1f-b28c-30f361afcd55.txt
new file mode 100644
index 0000000000000000000000000000000000000000..dd2752718648555599430cc35078ebb587c7a77a
--- /dev/null
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+
+--- Page 1 ---
+UUID:EEB0E26D-3BF2-4D38-8D94-4251A03344D4 Redacted Diagnosis: A: Left kidney, nephrectomy - Renal cell carcinoma, chromophobe type, eosinophilic variant, tumor size 3.5 cm in greatest dimension, nuclear grade 2 (of 4), tumor confined to kidney, surgical margins free of tumor. - Renal vein, artery and ureter with no tumor seen. - Portion of adrenal gland with no tumor seen B: Left adrenal gland, mass removal - Adrenal myelolipoma, tumor size 14 cm in greatest dimension. tcD-o-3 Comment: Carcunons, Renal cell None. Cuomephobe type 8317l3 Clinical History:e Cb4.9 year-old male with left adrenal mass. nO 9/z4|13 Gross Description: Received are two appropriately labeled containers.. Container A: Specimen fixation: formalin Type of specimen: nephrectomy Size and weight of specimen: 500 grams, 14.5 x 10.0 x 4.8 cm Presence/absence of adrenal gland: questionably present, an area of yellow/orange discoloration is present in the perirenal adipose tissue, but not definitive for an adrenal gland. Tumor description: circumscribed, yellow/tan, soft, and partially encapsulated Tumor size: 3.5 x 3.5 x 3.0 cm Presence/absence of multicentricity: absent, one focus is identified Confinement/Non-confinement to kidney: the tumor grossly appears to contain questionable areas of extracapsular extension into the surrounding fat Extent of invasion:. Perirenal adipose tissue: questionably involved
+
+--- Page 2 ---
+Renal vein: tumor does not grossly involve Ureter: tumor does not grossly involve Surgical margins: Perirenal adipose tissue: extends to within 0.8 cm of the closest black inked deep soft tissue margin Renal vein: negative Renal artery: negative Ureter:negative Description of kidney away from tumor: has a pink/tan, smooth, and grossly. unremarkable cut surface, with distinct corticomedullary junctions; the cortex contains two linear incisional defects, containing suture material, one located on each pole Lymph nodes (hilar): none Tissue submitted for special investigations: none Block Summary: A1 - vascular and ureteral margins A2 - tumor at closest approach to black ink A3,A4 - tumor at area of questionable extracapsular extension A5,A6 - additional representative tumor A7 - additional representative normal kidney A8 - representative section of area with adipose tissue containing an orange/yellow discoloration (possible portion of adrenal gland) Container B is additionally labeled "left adrenal mass." It holds a 1010 gram, 14.2 x 13.2 x 7.0 cm ovoid, circumscribed, soft tan/gray mass, containing areas of disrupted surface. A 10.0 x 1.0 cm area contains an orange/yellow minimal amount of adherent portion of tissue, consistent with adrenal gland. Sectioning reveals a soft, yellow/tan, focally hemorrhagic and focally necrotic cut surface. This mass. diffusely abuts the blue inked surgical margin. The area underlying the. yellow/orange surface has a red/brown, hemorrhagic cut surface, with a small, approximately 0.5 x 0.1 cm rim of orange yellow tissue, consistent with adrenal gland. B1-B5 - representative sections 36 - sections of area containing yellow/orange possible adrenal gland
+
+--- Page 3 ---
+Light Microscopy: Light microscopic examination is performed by Dr. Specimen A: Histologic tumor type/subtype: renal cell carcinoma, chromophobe type, eosinophilic variant Histologic grade (if applicable): 2 (of 4) Tumor size (greatest dimension): 3.5 cm Extent of tumor invasion: Capsular invasion/perirenal adipose tissue: negative Renal vein: negative Ureter: negativee Blood vascular: negative Lymphovascular: negative Histologic assessment of surgical margins: Perirenal adipose tissue: free of tumor Renal vein: free of tumor Renal artery: free of tumor Ureter: free of tumor Adrenal gland: no tumor seen. Separately submitted specimen B shows a 14 cm myelolipoma of the adrenal gland. Lymph nodes: not identified Other significant findings: none
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diff --git a/output/text/47255546-6c72-43eb-a7c3-c926fd8ba0c1.txt b/output/text/47255546-6c72-43eb-a7c3-c926fd8ba0c1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c4eaaa2b219c4a2f354389daa2e435a4fa33686c
--- /dev/null
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+
+--- Page 1 ---
+TCGA-AL-3468 SURGICAL PATHOLOGY REPORT Clinical History/Diagnosis: Renal Mass with Hx of CML. Source of Specimen(s): 1: Right 11th Rib 2: Right lower pole of kidney cyst 3: Right Peri-nephric fat. 4: Lower Pole Renal Mass-Right 5: Deep Margin-Right Renal Mass Gross Description:. Received in five parts. Source of Tissue: 1. Labeled #1, "right 11th rib". Gross Description: Received fresh with patient name and medical record. number labeled "right 11th rib" is a 3.5 x 1.0 cm tan fragment of rib having a minimal amount of attached soft tissue. A representative section. is submitted in one block, following decalcification. Designation of Sections: Block 1 Summary of Sections: undesignated-1 ********************* Source of Tissue: 2. Labeled # 2, "right lower pole of kidney cyst" Frozen Section Diagnosis: 2FS- CONSISTENT WITH BENIGN CYST PER Gross Description: Received fresh in a container with patient's name and medical record number labeled "right lower pole of kidney cyst". It. consists of a portion of tan fibromembranous tissue measuring 9.0 x 5.0 x. 0.2 cm with some attached associated adipose tissue measuring up to 0.2. cm. No markedly thickened areas or suspicious lesions are found. Representative sections are submitted for frozen section and the residue. is in 2FS. Additional representative sections are submitted in 2A *****************************************************k****************** Source of Tissue: 3. Labeled #3, "right perinephric fat". Gross Description: Received fresh with patient name and medical record. number labeled "right perinephric fat" are 322 grams of yellow-tan. perinephric fat. The fragments are sectioned to reveal yellow-tan glistening lobulated cut surfaces. Representative sections are submitted in three blocks..
+
+--- Page 2 ---
+Designation of Sections: 3A-3C Summary of Sections: multiple ***************************************************** Source of Tissue: 4. Labeled # 4, "lower pole renal mass-right" Frozen Section Diagnosis: 4FS- RENAL CELL CARCINOMA, FAVOR PAPILLARY Gross Description: Received fresh in a container with patient's name and. medical record number labeled "lower pole renal mass- right". It consists of a 210 gram ovoid soft mass measuring 8.0 x 8.0 x 6.7 cm. There is some. associated fibroadipose tissue measuring up to 1.0 cm and the mass is predominantly covered with grayish-tan smooth capsule. At the margin, there is some normal appearing kidney parenchyma which is inked with black. Approximately 10% of the resection margin contains white. urothelium consistent with calyceal system. The specimen is sectioned disclosing a soft orangish-yellow to reddish-brown tumor. The tumor is approximately 0.2 cm from the nearest margin and does not grossly invade into capsule. One representative section from the tumor closest to the margin is submitted for frozen section and the residue is in 4FS. Representative tissue is procured for Cytogenetics. Representative sections are submitted in 4A-G.. Designation of Sections: 4A-4C- additional sections of tumor in relationship to parenchyma margin, 4D-4G- tumor in relationship to capsule. ************************************************************************ * Source of Tissue: 5. Labeled # 5, "deep margin- right renal mass'. Frozen Section Diagnosis: 5FS- NO TUMOR SEEN  Gross Description: Received fresh in a container with patient's name and medical record number labeled "deep margin- right renal mass". It consists of two fragments of brownish-tan tissue measuring 0.4 and 0.6 cm. respectively. Both fragments were submitted for frozen section. consultation and the residue is in 5FS.. Final Diagnosis: 1. Right 11th rib: Hypercellular trilinear marrow with left-shifted myeloid maturation consistent with history of chronic myelogenous leukemia.
+
+--- Page 3 ---
+2. Right lower pole of kidney cyst.. Benign cyst. 3. Right perinephric fat: Fibroadipose tissue; no tumor seen.. 4. Lower pole renal mass- right:  Renal cell carcinoma, papillary subtype.- The 8.0 cm carcinoma is confined. to renal parenchyma. - Angiolymphatic invasion is not identified.. - The deep margin is free of tumor.. 5. Deep margin- right renal mass:. No tumor seen. pTNM: T2 Nx Mx. Procedures/Addenda Addendum Diagnosis At the request of the primary clinician, additional information is. reported. The diagnoses are unchanged. The right lower pole renal cell carcinoma (part 4) is a type I papillary. carcinoma. FC Cytogenetics Solid Results-Comments CYTOGENETIC ANALYSIS REPORTS DIAGNOSIS: Renal Mass KARYOTYPE: Abnormal karyotype: 52,X,-Y,+3,+7,+7,+10,+12,+16,+17,+20,-21[20] RESULTS: The renal mass was harvested after seven and eight days in culture. The chromosomes from twenty metaphases were counted and analyzed, and three of these metaphases were karyotyped by G-banding. The modal chromosome number was 52, and all of the cells had an abnormal karyotype. Abnormalities were.all numerical and included an extra copy each of chromosomes 3, 10, 12, 16, 17, and 20, two extra copies of. chromosome 7, and a missing chromosome 21. chromosome. Papillary renal adenomas and carcinomas have been reported to contain a unique
+
+--- Page 4 ---
+combination of autosomal trisomies along with loss of chromosome The constellation of trisomies includes chromosomes 7, 12, 16, 17, and 20, all of which are found in this patient' s karyotype. The literature suggests that tumors with tri- or tetrasomy 7 and 17 correspond to papillary adenomas and that tumors with more complex karyotypic changes are papillary carcinomas.
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diff --git a/output/text/472611ef-890a-4f45-a5d8-25a790246e4a.txt b/output/text/472611ef-890a-4f45-a5d8-25a790246e4a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..212306328c748f421a8eb9456d2a5781afbe47df
--- /dev/null
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+
+--- Page 1 ---
+Diagnosis:  Right hemicolectomy preparation with an ulcerated colon carcinoma of histological type of a moderately differentiated colorectal adenocarcinoma, measuring 3.5 cm in diameter at the widest point, located in the passage from the cecum to the ascending colon. Invasive spreading of the tumor to the muscularis propria. Colonic mucous membrane with a small solitary tubular adenoma with moderate epithelial dysplasia (synonymously: mild intraepithelial neoplasia). A coarse, nodular calcified focus of the mesenterium. It is most likely a completely calcified lymph node. Oral and aboral resection margin is tumor-free. 31 regular lymph nodes are tumor-free with uncharacteristically reactive changes. Tumor stage therefore pT2 nN0 (0/31) V0 L0; G2 R0.
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diff --git a/output/text/4729c3d0-8aed-4169-8737-31aafed89927.txt b/output/text/4729c3d0-8aed-4169-8737-31aafed89927.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8e57ca9bb5c554404d1b2f1033ac85922e4b3f52
--- /dev/null
+++ b/output/text/4729c3d0-8aed-4169-8737-31aafed89927.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+-5A63871F92A0 TCGA-DK-A3IT-01A-PR Redacted SURGICAL PATHOLOGY REPORT Patient Name: Accession #: Med. Rec. #: Date of Procedure: DOB: (Age:  Location: Date of Receipt: Gender: M Service:  Urology Date of Report: Ref. Physician: Account #: Patient Address: Billing Type: INPATIENT  Additional Copy to: Ref. Source: Clinical Diagnosis & History: Patient with previous renal transplant on chronic immuno suppression, HGT2 bladder lesion, radical cystectomy and bilateral nephro-U. Specimens Submitted: 1: Right ureter (fs) 2: Bladder, prostate and seminal vesicles, radical cystoprostatectomy 3: Left pelvic lymph nodes, resection 4: Left vas deferens 5: Left kidney 6: Portion of left adrenal gland 7: Right kidney DIAGNOSIS: 1.Right ureter, biopsy (fs):. Benign segment of ureter 2. Bladder, prostate and seminal vesicles, radical cystoprostatectomy: a. Part# 2 Tumor Type: 1cs-0-3 Invasive urothelial carcinoma, NOS Caucinomu.nrvihilisL,N0s 8120f3 Histologic Grade: High grade Site : b1addir,1atral wall e 41) Pattern of growth of the Non-Invasive component: Flat (in situ carcinoma) Focal Pattern of growth of the Invasive component: Infiltrating Tumor Multicentricity: Not identified Bladder Local Invasion:  Perivesical soft tissues Extravesical Tumor Extension: Right ureter uninvolved Urethra uninvolved Invasive carcinoma is present in the region around the left ureteral orifice Vascular Invasion: Identified Perineural Invasion: Identified Surgical Margins: Free of tumor aseisc wI-T5F7Vn Non-Neoplastic Mucosa: Exhibiting ulceration Page 1 of 6
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT Exhibiting foreign body reaction. Exhibiting proliferative cystitis (Brunn's nests, cystitis cystica, cystitis glandularis) Prostate: Other Please see Part B Seminal Vesicles: Not involved Perivesical Lymph Nodes:. Not identified The Pathologic Stage is (AJCC 2002): pT3 (Invasion of perivesicle soft tissue).  PR0 (No involvement of prostate) b. Part# 2 Tumor Type: Adenocarcinoma Gleason's Grade: Primary Gleason grade:3 Secondary Gleason grade:4 Total Gleason score:7 Tumor Location: Involves Right anterior Vascular Invasion: Not Identified Perineural Invasion: Not identified Tumor Multicentricity: Not identifed High Grade Prostatic Intraepithelial Neoplasia:. Identified Capsule: Tumor confined to prostate Seminal Vesicles: Not involved Bladder Neck: Not Involved Surgical Margins: Free of tumor Non-Neoplastic Prostate: Exhibits nodular hyperplasia Staging (AJCC 1997): pT2a (confined to the prostate & capsule, involving one lobe) 3.Left pelvic lymph nodes, resection:. Part# 3 Lymph Node Dissection: Benign lymph nodes Number of lymph nodes examined: 7 Number of lymph nodes with metastatic disease: 0. Page 2 of 6
+
+--- Page 3 ---
+SURGICAL PATHOLOGY REPORT Specimen entirely examined 4 Left vas deferens, resection:.  Benign fibromuscular and vascular tissue. 5. Left kidney, nephroureterectomy:. Histologic changes consistent with end-stage renal disease with diffuse glomerulosclerosis, extensive thyroidization and atrophy of tubules and interstitial chronic inflammation Vasculature with diffuse concentric myointimal hyperplasia Benign renal pelvic urothelial mucosa with proliferative changes 6. Portion of left adrenal gland, resection: Benign adrenal gland 7. Right kidney, nephroureterectomy: Histologic changes consistent with end-stage renal disease with diffuse glomerulosclerosis, extensive thyroidization and atrophy of tubules and interstitial chronic inflammation Vasculature with diffuse concentric myointimal hyperplasia Benign renal pelvic urothelial mucosa with proliferative changes I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT 1 HAVE REVIEWED AND APPROVED THIS REPORT. *** Report Electronically Signed Out *** Gross Description: 1). The specimen is received fresh for frozen section consultation, labeled "Right ureter" and consists of a segment of ureter measuring 1 x 0.5 cm. The specimen is bisected and entirely submitted for frozen section. Summary of sections: FSC - frozen section control 2). The specimen is received fresh, labeled "bladder, prostate, and seminal vesicles".  It consists of a bladder with attached prostate and adnexa measuring 16.5 cm from superior to inferior, 10.5 cm laterally and 4.5 cm from anterior to posterior.  The bladder measures 6.0 x 5.0 x 2.0 cm, the prostate measures 4.4 x 3.5 x 2.5 cm, the right seminal vesicle measures 3.4 x 2.0 x 0.9 cm, the right vas deferens measures 8.0 x 0.5 cm, the left seminal vesicle measures 3.2 x 1.8 x 0.9 cm and the left vas deferens measures 6.5 x 0.5 cm.. The anterior aspect of the bladder is inked blue and the posterior black. The prostatic urethral margin is. shaved and submitted. The bladder is opened along the anterior midline to reveal an ulcerated lesion measuring 3.2 x 2.2 cm grossly situated within the left lateral wall. The lesion measures 1.5 cm from the left orifice and 3.5 from the right. Both ureters are probe patent measuring up to 0.2 cm in maximum diameter. The lesion is sectioned to reveal underlying fibrotic papillary tissue extending to a depth of 1.3 cm grossly approaching into the perivesicular fat. The remaining bladder mucosa is inked tan. and otherwise grossly unremarkable.  Discrete perivesical lymph nodes are not grnssly identified. The prostate is serially sectioned to reveal diffuse tan-yellow nodularity. The entire prostate is submitted. is submitted. Representative sections are submitted. Summary of sections:. UTHM - urethral margin RUM - right ureter margin. LUM - left ureter margin T - tumor Page 3 of 6
+
+--- Page 4 ---
+SURGICAL PATHOLOGY REPORT RUO - right ureter orifice LUO - left ureter orifice LP - left posterior wall LA - left anterior wall RP - right posterior wall RA- right anterior wall TRI - trigone DOM - dome no cancer in a window of F - perivesical fat  RSV - right seminal vesicle LSV - left seminal vesicle RAP - right apex prostate LAP - left apex prostate RAM - right anterior mid prostate RPM - right posterior mid prostate LAM - left anterior mid prostate LPM - left posterior mid prostate RAB - right anterior base prostate RPB - right posterior base prostate LAB - left anterior base prostate LPB - left posterior base prostate ADD -- remainder of the prostate 3). The specimen is received in formalin, labeled "left pelvic lymph nodes", and consists of multiple pink tan firm lymph nodes  ranging from 0.5 cm to 3 cm in greatest dimension. The entire specimen including all identifiable lymph nodes is submitted. Summary of sections: LN - lymph nodes ADD - remainder of the specimen 4) the specimen is received in formalin labeled" left vas deferens", and consists of a 6.5 cm in length, 0.5 cm diameter tubular soft tissue.  Representative sections are submitted.. Summary of sections: R - representative 5). The specimen is received fresh, labeled "left kidney", and consists of a kidney with attached ureter, renal vessels, and perinephric fat. The kidney weighs 76.5 g.  The kidney measures 10 x 4 x 3 cm. The attached ureter measures 23 cm in length and 0.5 cm in diameter. The attached renal vein measures 0.2 cm in length and 1 cm in diameter. The renal vessels and ureter are grossly unremarkable.  The adrenal gland is not identified. The kidney is bivalved to reveal focal hemorrhagic pelvic mucosa and  diffuse fatty infiltration in the renal parenchyma. Sections through the remainder of the kidney reveal thin cortex measuring 0.4 cm in thickness and pink brown parenchyma.  No lymph nodes identified in the perinephric fat. Representative sections are submitted for permanent sections.. Summary of sections: UVM -- ureteral and vessel margins. P -- Renal pelvis, representative sections K -- Representative sections 6) the specimen is received in formalin labeled" portion of left adrenal gland", and consists of golden yellow glandular soft tissue in  aggregate measuring 3 x 1.8 x 1.5 cm. There is a moderate amount of the fat tissue attached to it. Representative sections are submitted. Summary of sections: R - representative sections Page 4 of 6
+
+--- Page 5 ---
+SURGICAL PATHOLOGY REPORT 7) The specimen is received fresh labeled "right kidney" and consists of a kidney with attached ureter, renal vessels, and perinephric fat weighing 550 g in total. The kidney weighs 71 g and measures 9 x 4.5 x 2.5 cm. The attached ureter measures 16 cm in length and 0.3 cm in diameter. The attached renal vein measures 0.8 cm in length and 0.6 cm in diameter. The renal vessels and ureter margins are grossly unremarkable. An adrenal gland is not identified. The kidney is bivalved to reveal tan-pink atrophic renal parenchyma with cortex measuring 0.6 cm in thickness.80% of the renal parenchyma is replaced by fat. The cortico-medullary junction is not well-defined. The calyces appear atrophic. No lymph nodes are identified in the perinephric fat.  Representative sections are submitted for permanent sections. Summary of sections: UVM -- ureteral and vessel margins P -- renal pelvis representative sections K -- representative sections kidney Summary of Sections: Part 1: Right ureter (fs) Block Sect. Site PCs 1 FSC 0 Part 2: :Bladder, prostate and seminal vesicles, radical cystoprostatectomy Block Sect. Site PCs 15 ADD 15 1 DOM 1 1 F 1 LA 1 1 LAB 1 1 1 LAM 1 1 LAP 1 1 LP 1 1 LPB 1 1 LPM 1 1 LSV 1 LUM 1 LUO 1 1 1 RA 1 1 RAB 1 1 RAM 1 RAP 1 1 1 RP 1 1 RPB 1 1 RPM 1 1 RSV 1 RUM 1 1 RUO 1 1 5 T 5 1 TRI 1 1 UTHM 1 Part 3:Left pelvic lymph nodes, resection Block Sect. Site PCs % 8 ADD LN 1 2 LN1 0 Page 5 of 6
+
+--- Page 6 ---
+SURGICAL PATHOLOGY REPORT Part 4: Left vas deferens Block Sect. Site PCs 1 R 2 Part 5:Left kidney. Block Sect. Site PCs 2 K 0 1 0 UVm 0 1 Part 6:Portion of left adrenal gland  Block Sect. Site PCs 1 R 2 Part 7: Right kidney. Block Sect. Site PCs 3 K 4 1 P 2 1 UVM 2 Intraoperative Consultation:  Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. Frozen section diagnosis: Right ureter (fs):Benign Permanent diagnosis: Same  Page 6 of 6 END OF REPORT
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diff --git a/output/text/473411dc-c722-42ca-beec-d8645f7a4acd.txt b/output/text/473411dc-c722-42ca-beec-d8645f7a4acd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a936a9577a797a6cea18164b84ff433654361d1a
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+
+--- Page 1 ---
+UUID:C0BABB5A-B0ED-42A6-A9D1-6B26843A375D TCGA-5M-AAT4-01A-PR Redac Date: SPECiMEN: terminal ileum, cecum, right colon, appendix and transverse colon. PROCEDURE: Right hemicolectomy with distal ileostomy. MACROSCOPY - Segment of right and transverse colons, opened along its longitudinal axis, with cecum, appendix, and terminal ileum. - Appendix shows 4.0 cm of length and 0.7 cm of diameter.. - The right and transverse colons measure 22.0 cm of length and 1.5 cm of mean diameter. - A vegetating tumor with elevated infiltrative borders and central ulceration, measuring 5.0 x 4.0 cm is found in the colonic mucosa 6.5 cm from the nearest surgical margin.. - Three lymph nodes are grossly identified in the 12.0 x 11.5 cm area of pericolic fat tissue. - The adjacent mucosa is pale and shows three 0.9 cm polyps each near the ileocecal valve  MICROSCOPIC EXAMINATION - Moderately differentiated tubular adenocarcinoma of the right colon. - Microscopic tumor extension: tumor invades until the fat subserosa.. - Lymph-vascular invasion: present. - Surgical margins free of neoplasia. - Moderate peritumoral lymphocytic infiltrate. - Moderate stromal desmoplasia.. - Extensive areas of necrosis in the tumor. - Number of lymph nodes examined: 3. - Number of lymph nodes positive for neoplasia: 0 - Adjacent intestinal mucosa with one villous adenoma with high grade epithelial dysplasia, and two polyps with low grade epithelial dysplasia. IcD-d-3 - Appendix displays no pathologic features. - Stage (TNM 7th edition): pT3 pN0 pMx. dndCarcunonrd NO3 814df3 PATHOLOGISTS CALE Site: Cleeendere cslen C18.2 5 s/Qi|i4
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diff --git a/output/text/473925cb-bce9-4526-a5c9-a715aa56f071.txt b/output/text/473925cb-bce9-4526-a5c9-a715aa56f071.txt
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index 0000000000000000000000000000000000000000..0e669472440037b3f2849ba11f8077d33b98b812
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+
+--- Page 1 ---
+UUID: 3D3C8809-0309-484B-9E1E-98A0A5613E85 Redacted TcD o3 8Qk0/3 Research Gross Description OKedny NgS Site.  male with left renal mass C64.9 QS 117/14 Research Dx CASE SUMMARY FOR NEPHRECTOMY FOR RENAL CELL CARCINOMA: Procedure: Laparoscopic partial nephrectomy Specimen laterality: Left Tumor site: Inferolateral cortex Tumor size: 1 x 1 x 0.7 cm Tumor focality: Unifoca! Macroscopic extent of tumor: Tumor limited to the kidney. Histologic type: Papillary renal cell carcinoma, type I. Sarcomatoid features: Not identified. Tumor necrosis: Not identified Histologic grade (Fuhrman Nuclear Grade): 2 Microscopic tumor extension: Tumor limited to the kidney Margins: Negative for carcinoma(tumor extends to within 0.5 mm of the parenchymal margin Lymph-Vascular invasion: Not identified Pathologic staging (pTNM): Primary tumor: pT1a: Tumor 4 cm or less in greatest dimension, limited to the kidney. Regional lymph nodes: pNX: Unable to assess. Distant metastasis: pM: Not applicable. Pathologic findings in nonneoplastic kidney: No significant histologic abnormalities.. Other tumors and/or tumor-like lesions: None identified. AJCC Staging (7th edition) pT1a pNX pM: Not applicable Research QC Tumor T1: 100% tumor nuclei 0% necrosis 0% normal Normal N1: 100% benign kidney Research Specimen Specimen Process Time. Blood draw time: Plasma frozen time Serum frozen time: Buffy coat frozen time: Tissue: Cold ischemia start time: Formalin fixation start time Frozen start time: Total cold ischemia time: Formalin fixation stop time: Total formalin fixation time:.
+
+--- Page 2 ---
+Specimen Weight Normal 1-112 mg Tumor 1-135 mg_ Specimen Size Plasma x 3 Serum x 1 Buffy coat x 1 Cryovials x 2  Normal x 1 Tumor x 1 Metastatic x 0 FFPE x 2 Normal x 1 Tumorx1( .-no FS) Metastatic x 0 Study Patient Consent Yes
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diff --git a/output/text/4742266f-7ed1-49ff-997d-435101a7b1c9.txt b/output/text/4742266f-7ed1-49ff-997d-435101a7b1c9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fb144f1e10c3e440853cd2fc1a60b48cdaf2993a
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+
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+Patient hIStoRy: Not given. PRE-OP DIAGNOSIS: Left renal cancer. POSt-OP DIagnOsIS:  Same. prOCEDURE: Left laparoscopic nephrectomy FINAL DIAGNOSIS: Kidney, Left, Laparoscopic nephrectomy - RENAL CELL CARCINOMA, CONVENTIONAL (CLEAR) CELL TYPE. B.  Fuhrman's nuclear graDe iS 3 of 4. C. The Greatest DIameter Of the Neoplasm IS 7.2 Cm. D. The NeopLAsm Is COnfined WIthin The RenaL Capsule. Tumor invaDes into the reNal veIn wIth InVolvement Of the vEssel wall. E. F: All SUrGICal maRGiNS ARe frEe Of The NeOpLASM. G. The Non-NeopLAsTic kiDney is unremarKabLe. H. the adrenal gland is not submitted. I. TNm STAGE: pT3b NX mX. MICrOsCOPIC: SyNOPTIC DATA - PRIMARy KIDNEy TUMORS SpEcimen type: Other: Laparoscopic nephrectomy. LATERALITY: Left TUMOR SITE: Lower pole FOCALITY: Unifocal TUMOR SIZE: Greatest dimension: 7.2 cm MAcrOscopic exTent Of TumOR: Tumor limited to kidney HIstoLogic Type: Clear cell (conventional) renal carcinoma HISTOLOGIC GRADE (Fuhrman Nuclear Grade): G3 PAThOLOgIC STAGINg (pTNm): pT3b  pNX Number of regional lymph nodes examined: 0 pMX  MARGINS: Margins uninvolved by invasive carcinoma ADrENAL GLAND: Not present VENoUs (LARgE vESSeL) inVASIOn (V): Present LymphaTic (SmALL veSseL) InvasiOn (L): Absent ADDITIONAL PATHOLOgIC FinDINGS: None identified.
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diff --git a/output/text/4744d1f7-57dc-4d90-8fb1-2dbf0175b5a0.txt b/output/text/4744d1f7-57dc-4d90-8fb1-2dbf0175b5a0.txt
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index 0000000000000000000000000000000000000000..c07155dea6aa1dcc47ccfa7dce354009088cb374
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+1cd-0-3 Carcinomn, Lobulw, lnvassve 8520|3 Site code: bresot, Nos c50.9 TSS Pt ID: 1s|9f10 lw SPECIMENS: A. LEFT BREAST WLE NEEDLE LOC UUID: BA87D188-A3B3-4A6F-B3AF-1FE82589E3570 B. SLN #1 TcgA-E2-A107-01a-Pr C. SLN #2 Redacted D. RIGHT BREAST E. SLN #3 F. ADDITIONAL SENTINEL LYMPH NODE RIGHT AXILLA G. RIGHT AXILLARY CONTENTS LEVELS 1 & 2 SPECIMEN(S): A. LEFT BREAST WLE NEEDLE LOC B. SLN #1 C. SLN #2 D. RIGHT BREAST E. SLN #3 F. ADDITIONAL SENTINEL LYMPH NODE RIGHT AXILLA G. RIGHT AXILLARY CONTENTS LEVELS 1 & 2 INTRAOPERATIVE CONSULTATION DIAGNOSIS: FSA-left breast: No definitive mass seen, tissue with fibrosis by Dr. to Dr. at. TPB-SLN #1: Lymph node negative for carcinoma. TPC/TPE-SLN #2 & #3: Lymph nodes positive for carcinoma. Called by Dr. to Dr at GROSS DESCRIPTION: A. LEFT BREAST WLE NEEDLE LOC Received fresh labeled with the patient's identification and "left breast WLE needle localization" is an. oriented (single-anterior, double-lateral, triple-superior) needle localized lumpectomy with out radiograph. Ink code: anterior-yellow, posterior-black, medial-green, lateral-red, superior-blue, inferior-. orange. The specimen is seriaily sectioned into 5 sections revealing dense fibrous tissue without a distinct mass. No tissue is procured. Entirely submitted: A1-A3: slice 1, lateral margin, perpendicular sections A4: slice 2, anterior A5: slice 2, posterior A6: slice 3, anterior A7: slice 3, posterior A8: slice 4, anterior A9: slice 4, posterior A10-A11: slice 5, medial margin, perpendicular sections B. SLN #1 Received fresh is a 3 x 0.8 x 0.5 cm lymph node. A touch prep is performed and the lymph node is. submitted entirely in cassette B1. C. SLN #2 Received fresh is a lymph node measuring 1.4 x 1.2 x 0.5 cm. One touch prep is performed and the. lymph node is submitted entirely in cassette C1. D. RIGHT BREAST Received fresh labeled with the patient's identification and "right breast" is an oriented 678 g, 24 x 21 x 5 cm mastectomy with 11.5 x 7 the skin ellipse and 1.7 cm everted nipple. Ink code: anterior/superior-. blue, anterior/inferior-orange, posterior-black. The specimen is serially sectioned into 12 slices from. medial to lateral with nipple and slice 5 revealing an area of dense nodular firm fibrous tissue, 10 x 8 x 4. cm, extending from the upper inner quadrant to the mid outer quadrant at is closest to the. posterior/deep margin at 1.5 cm. " Representatively submitted.. D1: slice 2, lower-superior anterior D2: slice 2, upper-inferior anterior D3-D8: slice 3, mid section submitted from superior to inferior. D9: slice 4, lower-superior anterior D10: slice 4, lower-superior posterior. D11: slice 5, lower-superior anterior D12: slice 5, lower-superior posterior D13: slice 5, made anterior
+
+--- Page 2 ---
+D14: slice 5, mid posterior D15: slice 5, upper-inferior anterior D16: slice 5, upper-inferior posterior. D17: slice 6, mid superior D18: slice 6, lower-superior posterior. D19: slice 6, upper-inferior anterior D20: slice 6, mid inferior D21: slice 7, mid superior D22: slice 7, mid inferior D23: slice 8, mid lower-superior D24: slice 8, mid upper-inferior D25: slice 9, mid upper-inferior D26: slice 9, mid inferior D27: slice 10, mid upper-inferior D28: slice 10, mid inferior D29: slice 11, upper-inferior posterior. D30: slice 1, mid D31-D32: nipple, perpendicular sections. D33: skin D34: 1 axillary lymph node E. SLN #3 Received fresh is a lymph node, 2 x 1 x 0.5 cm. A touch prep is performed and the Iymph node is submitted entirely in cassette E1. F. ADDITIONAL SENTINEL LYMPH NODE RIGHT AXILLA Received fresh is a piece of yellow-tan tissue 2.5 x 2.1 x 1 cm. Two lymph nodes are identified measuring 1.4 and 1.8 cm. Lymph nodes are submitted separately in cassettes F1-F2.. G. RIGHT AXILLARY CONTENTS LEVELS 1 AND 2 Received fresh is an aggregate of adipose tissue, 7 x 5 x 1.5 cm. Multiple lymph nodes are identified ranging from 0.1 to 2.1 cm; they have a variegated pink-tan cut surface. Lymph nodes submitted as follows: G1-G2: 4 lymph nodes each G3: 6 lymph nodes G4: 2 lymph nodes G5-G8: 1 lymph node each DIAGNOSIS: A. BREAST,LEFT, WIDE LOCAL EXCISION: - USUAL DUCTAL HYPERPLASIA WITHOUT ATYPIA, MICROCALCIFICATIONS IN BENIGN DUCTS AND FIBROCYSTIC CHANGES WITH FIBROSIS - FOCAL FAT NECROSIS AND MILD ACUTE INFLAMMATION, NO TUMOR SEEN. B. LYMPH NODE, SENTINEL #1, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (O/1). C. LYMPH NODE, SENTINEL #2, EXCISION: - METASTATIC CARCINOMA TO ONE OF ONE LYMPH NODE (1/1), MEASURING 0.8-CM WITH NO EXTRANODAL EXTENSION. D. BREAST, RIGHT, SIMPLE MASTECTOMY:  MULTIFOCAL, INVASIVE, LOBULAR CARCINOMA, SBR GRADE 2, MEASURING 10-CM - INVASIVE TUMOR PRESENT 2-MM FROM DEEP SURGICAL RESECTION MARGIN - METASTATIC CARCINOMA TO ONE OF TWO AXILLARY LYMPH NODES (1/2) - SEE SYNOPTIC REPORT AND SEE NOTE. E. LYMPH NODE, SENTINEL #3, EXCISION : - METASTATIC CARCINOMA TO ONE OF ONE LYMPH NODE (1/1), MEASURING O.7-CM WITH FOCAL EXTRANODAL EXTENSION. F. LYMPH NODE, ADDITIONAL SENTINEL, RIGHT AXILLA, BIOPSY: - METASTATIC CARCINOMA TO ONE OF TWO LYMPH NODES (1/2).
+
+--- Page 3 ---
+G. LYMPH NODES, RIGHT AXILLARY CONTENTS, LEVELS 1 AND 2, DISSECTION: - TWENTY LYMPH NODES, NEGATIVE FOR METASTASES (0/20). NOTE: Extensive and multifocal invasive lobular carcinoma is identified. The tumor grossly measures 10-cm. Microscopic examination reveals that the tumor extends from slice #1 to slice #8 (predominantly in the inner half, central and subareolar region, with extension to outer quadrants. SYNOPTIC REPORT - BREAST Specimen Type: Mastectomy Needle Localization: No Laterality:Right) Invasive Tumor: Present Multifocality: Yes WHO CLASSIFICATION Invasive lobular carcinoma 8520/3 Tumor size: 10cm Tumor Site: Upper outer quadrant Lower outer quadrant Upper inner quadrant Lower inner quadrant Central Margins:  Negative Distance from closest margin:  0.2cm deep Tubular Score: 3 Nuclear Grade: 2 Mitotic Score: 1 Modified Scarff Bloom Richardson Grade: 2 Necrosis: Absent Vascular/Lymphatic Invasion: None identified Lobular neoplasia: None Lymph nodes: Sentinel lymph node and axillary dissection Lymph node status: Positive 4 / 27 Extranodal extension DCIS not present ER/PR/HER2 Results ER: Positive PR: Negative HER2: Negative by FISH Performed on Case:  HER2 by FISH performed in outside facility Pathological staging (pTN): pT 3 N 2a SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimen:  Surgical Excision Block Number: D1 ER: Positive Allred Score: 8 = Proportion Score 5 + Intensity Score 3 PR: Negative Allred Score: 0 = Proportion Score 0 + Intensity Score 0 COMMENT: The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring. range from 0 to 8. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2.
+
+--- Page 4 ---
+METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours.  Immunohistochemistry was nerformed usina the mouse anti-human ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) provided by following the manufacturer s instructions. This assay was not modified. Interpretation of the ER/PR immunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal review of staining performance. CLINICAL HISTORY: None given PRE-OPERATIVE DIAGNOSIS: Right breast cancer, left abnormal imaging Gross Dictation:., Pathologist, Microscopic/Diagnostic Dictation:., Pathologist, Final Review: Pathologist. Final Review: Pathologist. Final Review: Pathologist, Final: Pathologist,.
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diff --git a/output/text/4799cf13-0c83-4a4b-8e60-13c5d70f493c.txt b/output/text/4799cf13-0c83-4a4b-8e60-13c5d70f493c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..dee6fa1091c01071b511f7890a72caa8a88bfef8
--- /dev/null
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+
+--- Page 1 ---
+ORIGINAL REPORT NPSCINEN A. Mase head of puncreas. 4. Body of pandreas. c. Galibladder. D. Bile duot margin. E. Hepatic artery node. F. Pancreag margin. ?. Whipple's specimen. CLINICAL HISTORY: Fancreatie mase. DIAQOSIS: A1 PANCREAS, (MEAD), BIOPSY1 INVASEVE DOCTAL ADEINOCARCENOMA. B1 PANCREAE, (BODY) BEOPSY: CHRCNIC PAAKREATITIS. Cp GALLRLADDER, CHOLCYSTRCTCNY: CERONIG CHOLECYSTITIS. ONE DENEGN LYMPE NODE (0/1). D: (SILE DUCT HARGIN), DIOPAY: CONSISTENT WITA LON CRADE DYSPLASIA. E: LYMPe nODs,d (RGPATIC ARTARY), EXCrSION: METASAATIC ADRROCARCINONA IE PRESENT (1/1). NO EXTRANODAL SOAT TISSOR ASTON IS SREN. Fr (PANCREAS HARQZN), BIOPSY: CONSISTENT NITH CARONIC PAKREATTTIS. PANCRRATOXCHERECTCY HLIH PARTIAL GASTRECTOMY: BODERATEZY DIFFERSNTIATED TNVASIVK PANCRSATOBILIARY DUCTAL + ADENOCARCLNOMA 4 TONOR SIER6.0x4.5x2.0 CM. TEOR SETXNDS DHIO THE PERIPANCREATIC SOFT TISSUE, AND EXTENDS TO LATERAL RESECTION MARGDNS. THS DODENAE HOCOSA IS INVOLVED. COMNON BIIR DUCT' MARGIT SAOWS LON QRADE DYSPLASTA, THE PROKDAL (GASTRIC) AND DISTAL (DDODENAL) MARGINS ARE FREE OF TWOR. THE PANCRKATIC RHEECTEON MARGIN DEANSTRATES ETRA-PANCRRATIG CARCIAOHA INVOLVLNQ SOAIL NHRVES.
+
+--- Page 2 ---
+DIAGNOSIS: LYMPR NDAS: HELASTATIC CARCINOXA IS FRESKNT DT CNE OF TRO CKEOION BILE DUCT LYAPH NODRs 71/2) HETASTATIC CARCDRHA (NITE ATRNODAL SOFT TISSOE RTENBICN) IS PRESKAT TN FOUR OF HINE PERIDUODRNAL LYPH NOOEE (4/9J. METASTATIC CARCINHA (WITE EXTRARODAL SOET TISSDE RXTEHSTON) IS PRESENT DN NTN OF NINE PERYPANCREATIC LYME NODES (9/9). THE MON-REOPLASTIC PANCREAS HAS FEATORES OF CNRONIC PANCREATITIS. THR STCACN SAOWS A ILD REACTIVE GASTRIIIS. TAR DOODEVON EAS ACUIE ISCDMIC CHANGKS DISTALLY. GROSS DESCRIPTION; A, The specimen conaigts of on. Rmbedded in toto as s.. I tan tissue measuring 0.3 cm.. The specinen consiats of one core mensuring 1.5 am in longth and 0.l. cn in diameter. Enbedded in toto as Qs. The specimen consists of an intact cholecysteotomy specimen measuring 7.0 x 2.8 x 2,5 pm, in Ci.  The cystic duct is Q.3 cn in diameter. Thore are no gallstones and the bile is thick and graen..  The ruucosa is unremarkahle and the wall. thiokngs is 0.l cn. presant within the mucoaa. Repreaentative sectlons of~duct and wall are submitted in cz, Saction ot thickenod iold is submitted in C3. D. The specimez consiats of a white duct with twa lwnens, the diametr of the first in 0,6 and the diameter of the other is 0,7 cm. Submittad in toto in cassette D.. Tha spaclmen ia 4. The spocimen congists 0f a t*n-hrorm node, 1.5 x 1.5 x 0,3 cm. in toto in cassette e3.. Submitted FINAL
+
+--- Page 3 ---
+ATHOLOGY REPORI Division Haad. Xoqury Rumbeyei GRO#K DESCRIPTION: F. The specimon conaists ot one plece.. Imbedded in toto ag as.. saue meaauring 0.9 x 0.4 x 0.1 cu, g.  Tha apecimen consieta of pancreaticoduodenectony with partial gaatrectaty.  The entire specimen tron proximal to distal measuxes 32.5 x 6.0 cm. and is painted with siiver nitrate. The gastric segmant mersureo 3,s x 6,5 cm, and the duodenal segment is 20.0 x 6.0 on. 6.0.x 4.5-x.3.0 cm. The pancreatic xesection margin is painted blue, The pancreatdc head measures The gastxic segment is unzenarkable, The serosal aurface of the duodenwn hap mildadheoione:- -The distaI portion of the duodenal mucosa hag  duaky appearance. Juot by the ampulla ot vater, thare is a 1.3 x 0.7 cn ulcerated tha pancreatio head.'The conunon bile duct'is openod, and ds patent, At the. more proximal aspect, towards the cyotic duct, it is hemorrhngic. The pancreatic duot, howaver, is not probe patent, Two lynph nodes are identified naax the commen bile duct, moasuring 3,0 cm and i,.7 cm, respactively. Qactioning the pancreatic head, the out eurface is a tan-grey and #lrm with a on central brown-red foous azound the duct, The litm axea is in~ontinuity xith the duodenal wali, and thls abnorual xrea of pancreas meagures approximxtely 3.0x2.2 x 1.1 m. Specimen is alao submitted for ths anpulla #tudy, where a 3.0 x 3.0 cm block of duodenum with ampulla of vater is taken and serially seotioned. Specinen is oubmttted an follows: G1. tnface comnon bile duct G2. larger couuon biie duct node G3. Becond. comnon bile duct node bisected G4. proximal perpendicular resection margin 35. distal perpendicular resection margin G6. transition of possible normal duodenal mucosa to ischemic 97. represantativa section of nozmal duodenum 8r perpendioular section of the conunon bile duct with painted black margin 39. entace shava of pancreatic xesection margin Q10-11. transected first section furthest fxom the anpulln. $12-1$, 014-16. Iollowing serial aection trisected FINAL
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diff --git a/output/text/47ca74de-fb79-4810-917f-3160b9fe2af9.txt b/output/text/47ca74de-fb79-4810-917f-3160b9fe2af9.txt
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index 0000000000000000000000000000000000000000..1a7027d1eb231ed849aaf25c026e067f65adab5d
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+3REAST TISSUE CHECKLIST Ef058 Specimen type: Radical mastectomy Specimen size: Not specified Tumor site: Breast Tumor size: 4.2 x 3.6 x 3.6 cm SON Grossly evident lesion: Yes rpm Histologic type: Infiltrating ductal carcinoma Histologic grade: Poorly differentiated Tumor extent: Not specified. Lymph nodes: 0/8 positive for metastasis (Regional 0/8) Right, upper Extracapsular invasion of the lymph nodes: Not specified outer Margins: Not specified quadrant Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified -0 eted Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments... None..
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diff --git a/output/text/482fbcdb-bc33-4117-88e6-6aa371094135.txt b/output/text/482fbcdb-bc33-4117-88e6-6aa371094135.txt
new file mode 100644
index 0000000000000000000000000000000000000000..996225f6581ad85dd712cb0555187d5cc799f5d7
--- /dev/null
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+
+--- Page 1 ---
+Clinical Diagnosis & History: year old female with stage Iv breast carcinoma, debulking surgery. Specimens Submitted: 1: sp: Right breast and axillary contents level 1. DIAGNOSIS: 1. BREAST, RIGHT; MODIFIED RADICAL MASTECTOMY:S - INVASIVE CARCINOMA, HISTOLOGIC GRADE II/III (MODERATE TUBULE FORMATION) TO HISTOLOGIC GRADE III/III (SLIGHT OR NO TUBULE FORMATION). NUCLEAR GRADE III/III (MARKED VARIATION IN SIZE AND SHAPE), MEASURING AT LEAST IO CM IN LARGEST DIMENSION GROSSLY. INVASIVE CARCINOMA SHOWS MICROPAPILLARY FEATURES. FOCAL EXTRACELLULAR MUCIN IS ALSO NOTED. - DUCTAL CARCINOMA IN SITU (DCIS) IS ALSO IDENTIFIED, SOLID CRIBRIFORM MICROPAPILLARY AND FLAT TYPES, WITH HIGH NUCLEAR GRADE, AND EXTENSIVE NEcROSIS. - LOBULAR INVOLVEMENT BY DCIS IS PRESENT.S UUID:5EFC16F4-7FC7-479E-93F7-AEDC2D350A22 - THE DCIS CONSTITUTES LESS THAN OR EQUAL TO 25% OF THE TOTAL TUMOR MASS, TCGA-A0-A035-01A-PR Redacted AND IS PRESENT ADMIXED WITH AND AWAY FROM THE INVASIVE COMPONENT. - THE INVASIVE CARCINOMA IS LOCATED IN ALL FOUR QUADRANTS. - THE DCIS IS LOCATED IN ALL FOUR QUADRANTS. -THE NIPPLE IS INVOLVED BY INVASIVE CARCINOMA. - CALCIFICATIONS ARE PRESENT IN BOTH THE IN SITU AND INVASIVE CARCINOMA. - VASCULAR INVASION IS PRESENT.S - THE SKIN IS INVOLVED BY INVASIVE CARCINOMA BY DIRECT EXTENSION INTO THE DERMIS. - THE ATTACHED SKELETAL MUSCLE IS EXTENSIVELY INVOLVED BY INVASIVE CARCINOMA BY DIRECT EXTENSION. - INVASIVE CARCINOMA IS CLOSE (LESS THAN O.1 CM) FROM THE NEAREST DEEP MARGIN. - THE NON-NEOPLASTIC BREAST TISSUE IS UNREMARKABLE.S - FOCAL CHANGES OF PRIOR PROCEDURE ARE NOTED IN THE AXILLARY TAIL. - METASTATIC CARCINOMA IS PRESENT IN TWO OUT OF TWO LEVEL I LYMPH NODES (2/2). ADDITIONAL SECTIONS OF THE AXILLARY TISSUE HAVE BEEN SUBMITTED AND THE FINDINGS WILL BE REPORTED IN AN ADDENDUM. - NUMEROUS FOCI OF METASTATIC CARCINOMA ARE NOTED IN THE AXILLARY SOFT TISSUE, WITH THE LARGEST MEASURING AT LEAST 1.4 CM. ** Continued on next page ** tc-u-3 85 a3J3 Site: brsat, nos c50.9 h if3#f1
+
+--- Page 2 ---
+Immunohistochemical stains were performed on formalin-fixed tissue with. the following results for invasive carcinoma (block 1-8): ESTROGEN RECEPTOR intensity. Progesteronr prrrdtor HER2 90% nuclear staining with strong (5% of invasive tumor cells exhibit complete membranous staining; Uniformity of staining: absent; Equivocal (focal 2+). FIsh will be performed. Negative (no nuclear staining) Homogeneous, dark circumferential pattern: absent) The carcinoma is positive for E-cadherin, supporting lobular differentiation. Comment: an FDA-approved rabbit monoclonal primary antibody (clone 4bs) directed Controls are satisfactory. Ventana' s PAThwAy anti-HER-2/neu is against the internal domain of the c-erbb-2 oncoprotein (Her2) for immunohistochemical detection of HeR2 protein overexpression in breast cancer tissue routinely processed for histologic evaluation. The HeR2 test results are reported in accordance with the Asco/cAp guideline recommendations for HeR2 testing in breast cancer (J Clin Oncol 2007; 25(1) :118-145). approved. The ER and pR rabbit monoclonal antibodies are also FDA Some of the immnohistochemistry and Ish tests were developad and their performance characteristics were determined by the Department of Pathology. They have not been cleared or approved by the us Food and Drug Administration. The FpA has determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA : 88) as qualified to perform high complexity clinical laboratory testing. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL). AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. ** Report Blectronically Signed Out *** Gross Description: 2 M.D. 1) The specimen is received fresh labeled, *right breast and axillary. contents level 1*, ! axillary contents. The breast measures 20 x 15 x 5 cm with overlying skin M.D. ellipse measuring 18 x 7 x 0.2 cm. Situated centrally on the skin surface is . It consists of a breast with attached a fixed, and retracted nipple measuring 1.5 x 1.0 x i.0 cm. The surrounding skin is markedly thickened (up to 0.6 cm). A suture demarcates the axillary contents which measures 7 x 5 x 2 cm. The posterior surface of the breast is ** Continued on next page **
+
+--- Page 3 ---
+inked black and the anterior blue. Part of the posterior surfaca of the 'The specimen is serially sectioned to reveal an irregular tumor bed (10 x 8.3 x' 5.1 cm) with poorly defined white, firm and tan areas. The tumor bed occupies almost the entire breast volume, extending throughout all four quadrants. The tumor bed is located 0.2 cm from the posterior margin, 0.3 cm from the anterior margin, and 0.5 cm from the skeletal muscle. The remaining breast tissue shows yellow fatty areas with foci of fibrosis. The axillary tissue is dissected to reveal 13 possible lymph nodes, ranging in size from nodes are entirely submitted. The specimen is photographed. Tissue is submitted to Tps.s Summary of sections: N - nipple, nipple base and tumor S - thickened skin PM - posterior margin AM- anterior margin Dsm -  deep skeletal muscle T- tumor central region and closest margins, continuous cross sections, taken  from medial to lateral UIQ upper inner quadrant LIQ lower inner quadrant UOQ upper outer quadrant LOQ lower outer quadrant L1 - axilla, level one lymph nodes AX axillary tail, entirely submitted Summary of Sections: Part 1:. SP: Right breast and axillary contents level J 3 Block Sect. Site. PCs ** AM 1 11 ax 11 DSM 1 9 L1 9 LIQ 2 2 LOQ 2 N 3 PM 1 1 10 2 UIQ 2 UOQ Procedures/Addenda: Addendum Date Ordered: Status: Signed Out ** Continued on next page **
+
+--- Page 4 ---
+Date Complete: Date Reported: By: Addendum Diagnosis PART #1 RIGHT BREAST AND AXILLARY CONTENTS: THE REMAINING AXILLARY TISSUE IS ENTIRELY SUBMITTED. NO ADDITIONAL LYMPH NODES ARE IDENTIPIED. *+ End of Report **
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diff --git a/output/text/485af90e-84b5-47de-9056-d3387ea841b4.txt b/output/text/485af90e-84b5-47de-9056-d3387ea841b4.txt
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index 0000000000000000000000000000000000000000..081c42dabb02fc6b4b067cb45a48d6424a8befba
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+
+--- Page 1 ---
+CnrCinon mfil+naH'ng duct, Nos 85oo/3 Procedure Date: Site: Brest Nos C 50.9 1/24JH Procedure Physician: Attending Physician/Copies To:. UUID:56EFCA58-2328-4C5C-9618-981447E76B12 TCGA-BH-A1EW-01A-PR 'Redacted Patient hIstory: *nnDATE of LMP: DATE OF LAST DELIVERY: : PRE-OR DIAGNOSIS: LT BR MASS POST-OP DIAGNOSIS: SAME OPERATIVE PROCEDURE: LT SEGM MAST-NEEDLE LOCS CLINICAL HISTORY: *  MATERIAL SUEMITTED: A)/LEFT) BREAST BIOPSY/MASS/SEGMENTAL MASTECTOMY, PROCUREMENT BY SURGICAL PROCEDURE B) LEFT NEW MARGIN TISSUE, PROCUREMENT BY SURGICAL PROCEDURE SUPERIOR INTRAOPERATIVE CONSULTATION: consurr: Left breast tissue: 11.0 by 5.0 by 4.5 cm breast tissue with 3.0 by 2.2 by 3.2 cm tumor. Superior 0.5 by 0.3 cm. Left breast, new superior margin": Segment of breast tissue, 1.0 by 8.5 by 1.3 cm. Surgical clips marks true. new superior margin. Grossly negative for tumor. ADDENDA:" Addendum MACROSCOPrc DEsCRIPTION: Block "A1" for ER/PR and Her-2/Neu. FINAL DIAGNOSIS: My signature is attostation that I have personally reviewed the subaitted material(s) and the final diagnosis reflects that ovaluation. ER/PR IMMUNOPEROXIDASE IDENTIFICATION OF ESTROGKN AND PROGESTERONE RECEPTORS IS CARRISD OUT ON SLIDE "AI". DISTINCT INTRANUCLEAR STAINING IS IDENTIFIED FOR SSTROGEN RECEPTOR (9Ot), BUT NOT FOR PROGESTERONE RECEPTOR. THEREFORE, ASTROGEN RECEPTOR IS INTERPRETED AS POSITIVE AND PROGESTERONE RECEPTOR IS INTERPRETED AS NEGATIVE. HER-2/NEU C-erbB2 (HER-2/NEU) DMUNOSTAINING IS CARRIED OUT ON MAGEE SURGICAL #M USINC A 1:30O DILUTION OF DAKO'S POLYCLONAL ANTIBODY A485 (DIRECTED AGADNST THE INTRACBLLULAR DOMAIN OP c- MO BLOCK "A1" (BREAST CANCER) arbB2) WITHOUT ANTIGEN RETRIEVAL. DISTINCT COMPLETE MEABRANE STAINING IS IDENTIFIED ONLY RARELY IN 5-1Ot OF TUMOR CELLS. THEREFORE, c-erbB2 (HER-2/NEU) IS INTERPRETED AS NEGATIVE (SCORE 1+). FINAL DIAGNOSIS: TIAGNOSIS : A)(LEET-BREAST, SEGMENTAL MASTECTOMY: - INFILTRATING MODERATELY DIFFERENTIATED DUCTAL AND FOCAL (APPROXIMATELY 1OS) INTRADUCTAL CARCINOM AND0.7CM .2CM - NOTTINGHAM SCORE OF 7 (TUSULE FORMATION 2/3, NUCLEAR ATYPIA 3/3, MITOTIC INDEX 2/3) FOCAL TUMOR ASSOCIATED MICROCALCIFICATIONSS  INFILTRATING CARCINOMA IS PRESENT WITHIN <I MM OF THE INKED SUPERIOR AND DEED MARGINS B) LEFT BREAST, NEW SUPERIOR MARGIN: - BENIGN BREAST TISSUE
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diff --git a/output/text/48608cfa-8594-40c1-925f-aee0cea8a7a9.txt b/output/text/48608cfa-8594-40c1-925f-aee0cea8a7a9.txt
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index 0000000000000000000000000000000000000000..29eceed54301d3ebd82016a758be548385b81b62
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+LCD-6-3 Tumor, Adrzual Cor tica) of untncwr. incertoin behausc 83 70 KB UUID:FE1CF238-753C-4DF4-A083-74DDC753DF45 -A5L3-01A-PR Redacted AO x/k13 Reference Pathology only:. Diagnosis: adrenocortical carcinoma
+
+--- Page 2 ---
+Patient # from Tissue Source Site Date of report Date of Surgery/specimen collection Site (confirmed to be adrenal) with laterality indicated Tumor size(s) Histologic diagnosis ACC Lymph Node Status x Pathologic information Weiss score
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index 0000000000000000000000000000000000000000..e48aa5987a99ad1c5b11a1533d92cff20f7be0bd
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+Clinical Diagnosis & History: Internal development of enhancing mass on MRI left breast, core biopsy showed infiltrating ductal carcinoma (Ipc) and Dcis, history of right infiltrating ductai carcinoma 0.3 cm 0/6 sentinel lymph node, status post right TM sentinel lymph node biopsy 8/05. Specimens Submitted: 1: sp: Sentinel node #1, level 1, left axilla (fs) 2: SP: Sentinel node #2, level 2, left axilla (fs) 3: SP: Left breast 4: sp: Nonsentinel noue left axilla DIAGNOSIS: 1) LYMPH NODE, SENTINEL #1 LEVEL I LEFT AXILLA; BXCISION:S CELLS, MEASURING O.5 MM (MICROMETASTATIC), IS IDENTIFIED IN ONE LYMPH NODE UUID:46841185-1719-46B4-835D-E469D6AEFF120 (1/1) ON ADDITIONAL H&E STAINED SECTIONS AND CYTOKERATINSS TCGA-A0-A03I-01A-PR Redacted IMMUNOHISTOCHEMCIAL STAINS (AE1:AE3). - THERE IS NO EXTRACAPSULAR EXTENSION OF CARCINOMA. 2) LYMPH NODE, SENTINEL #2 LEVEL II LEFT AXILLA; EXCISION:S - ONE BENIGN LYMPH NODE (O/1). - ADDITIONAL HE STAINED SECTIONS AND IMMUNOHISTOCHEMICAL STAINS FOR CYTOKERATINS AE1:AE3) SHOW NO EVIDENCE OF METASTATIC CARCINOMA. 3) BREAST, LEFT; MASTECTOMY: - INVASIVE DUCTAL CARCINOMA, NOS TYPE, POORLY DIFFERENTIATED, HISTOLOGIC GRADE III/III (SLIGHT OR NO TUBULE FORMATION), NUCLEAR GRADE III/III (MARKED VARIATION IN SIZE AND SHAPE), MEASURING 1.1 CM IN LARGEST DIMENSION MICROSCOPICALLY. - DUCTAL CARCINOMA IN SITU (DCIS) IS ALSO IDENTIFIED, SOLID TYPE. WITH HIGH NUCLEAR GRADE AND MINIMAL NECROSIS. - THE DCIS CONSTITUTES LESS THAN OR BQUAL TO 25% OF THE TOTAL TUMOR MASS, AND IS PRESENT ADMIXED WITH THE INVASIVE COMPONENT. - LOBULAR CARCINOMA IN SITU (LCIS) IS ALSO IDENTIFIED, CLASSICAL TYPE (TYPE A) INVOLVING SCLEROSING ADENOSIS.  THE INVASIVE CARCINOMA IS LOCATED IN THE UPPER OUTER QUADRANT.  THE DCIS IS LOCATED IN THE UPPER OUTER QUADRANT - NO INVOLVEMENT OF THE NIPPLE BY BITHER IN SITU OR INVASIVE CARCINOMA IS Ics-0-3 ** Continued on next page ** Sitei brust,Nvs C50.9 h 10/2y/n Criteria Primary Tun ual/Syn
+
+--- Page 2 ---
+IDENTIFIED. of - CALCIFICATIONS ARE PRESENT IN THR IN SITU AND INVASIVE CARCINOMA, AND IN BENIGN BREAST PARENCHYMA. NO VASCULAR INVASION IS NOTED. NO INVOLVEMENT OF THE SURGICAL MARGINS BY EITHER INVASIVE OR IN SITU CARCINOMA IS IDENTIFIED. - NO SKIN INVOLVEMENT BY CARCINOMA IS IDENTIFIED. THE SKIN SHOWS SEBORRHEIC KERATOSIS. THE NON-NEOPLASTIC BREAST TISSUE SHOWS BIOPSY SITE CHANGES, EXTENSIVE SCLEROSING ADENOSIS, RADIAL SCAR, ATYPICAL DUCTAL HYPERPLASIA (ADH), INTRADUCTAL SCLEROSED PAPILLOMA WITH FOCAL ATYPIA, FIBROADENOMA AND CYST FORMATION. RESULTS OF SPECIAL STAINS (ER, PR, HER2-NEU) ARE AS FOLLOW: Immunohistochemical stains were performed on formalin-fixed tissue with the following results for invasive carcinoma (block 6): ESTROGEN RECEPTORS 95% nuclear staining with strong intensity PROGESTERonE RECEPTORE 0% nuclear staining. HER2 (HercepTest; Negative (0 / 1+) (1% of invasive tumor cells exhibit complete membranous staining; Uniformity of staining: absent; Homogeneous, dark circumferential pattern: absent) Controls are satisfactory. Comment: HercepTestTM ( : is an FDA-approved method for assessment of HER2 protein overexpression in breast cancer tissue routinely processed for histological avaluation. The HeR2 test results are reported in accordance with the Asco/cap guideline recommendations for HER2 testing in breast cancer (J clin Oncol 2007; 25(1):1-28). 4) LYMPH NODE, NON-SENTINEL LEFT AXILLA; EXCISION: ONE BENIGN LYMPH NODE (O/1). I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. *** Report Electronically Signea Out *** Gross Description:. MD ** Continued on next page **
+
+--- Page 3 ---
+page 3of 1). The specimen is received fresh for frozen section consultation, labeled. "Sentinel node #1, level 1, left axilla" and consists of a single yellow-tan. firm and fatty lymph node measuring 4.7 cm. The node is trisected and two half are submitted for froren section in cassettes labeled as A and B. remaining fatty portion is bisected and entirely submitted for permanent The section. Summary of sections: Fsc-A -- frozen section control-A Fsc-Bfrozen section control RLN- remaining lymph node B 2. The specimen is received fresh for frozen section consultation,. labeled "Sentinel node #2, level 2. left axilla" and consists of a single pink-tan fatty lymph node measuring 1.6 cm in greatest dimension. Bisected and entirely submitted for frozen section. Summary of sections: Fsc --' frozen section control .D. 3). The specimen is recaived fresh, labeled "left breast, stitch marks axillary tail" and consists of a breast measuring 25 x 24 x 4 cm with overlying skin ellipse measuring 24 x 7.5 cm. situated central/superiorly on the skin surface is an everted nipple measuring 1.0 x 0.9 x 0.5 cm and. areola measuring 3.0 x 2.7 cm.  The skin shows a raised pigmented lesion measuring 1.0 x 0.5 x 0.2 cm, located 1.8 cm medial to the areola. No scar M is grossly identified on the skin surface. A suture demarcates the axillary aspect. The posterior surface of the breast is inked black and the radial margin is inked blue. The specimen is serially sectioned to reveal a firm,. white, well-circumscribed mass measuring 1.0 x 1.0 x 0.9 cm, located within the upper outer quadrant at the two o'clock aspect,. 1.2 cm from the deep margin. A hemorrhagic biopsy site is associated with the mass. An irregular area of white fibroglandular tissue is located immediately medial to the mass and measures approximately 5 x 5 x 3 cm. No additional discrete masses are grossly identified. Sectioning of the axillary aspect reveals no grossly. identifiable lymph nodes.  Representative sections are submitted. Tps is. taken. Summary of sections: N- nipple with nipple base S  skin with pigmented lesion D - deep margin BX  biopsy site tumor, entirely submitted FG - dense fibroglandular tissue medial to the mass UIQ  upper inner quadrant LIQ  lower inner quadrant UOQ upper  outer quadrant LOQ quadrant ** Continued on next page
+
+--- Page 4 ---
+M.D.  The specimen is received in formalin, labeled "non-sentinel node left axilla" and consists a single Iymph node with surrounding fibrofatty tissue measuring 1.2 x 0.4 cm. The lymph node is bisected and entirely submitted. Summary of sections: U-undesignated Summary of Sections:. Part 1:  SP: Sentinel node #1, level 1, left axilla (fs) Block Sect. Site PCs 1 FSC-A 1 FsC-b 1 1 RLN 3 Part 2: SP: Sentinel node #2, level 2, left axilla (fs) Block Sect. site PCs 1 Fsc 1 Part 3: SP: Left breast (sr) Block Sect. Site PCs 2 Bx 2 1 D 1 9 FG 9 1 LIQ 1 1 LOQ 1 1 N 1 s 22 T UIQ tOQ 1 Part SP: Nonsentinel node left axilla. Block Sect. Site pCs 1 U Intraoperative Consultation: Note:  The diagnoses given in this section pertain only to the ** Continued on next page **.
+
+--- Page 5 ---
+time of the intraoperative consultation. FROZEN SECTION DIAGNOSIS: GROSSLY LARGE AND FATTY LYMPH NODE. REPRESENTATIVE SECTIONS FROZEN AND SHOW NO TUMOR ON FROZEN SECTION. PERMANENT DIAGNOSIS: SAME MD End of Report
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index 0000000000000000000000000000000000000000..e471980203fe5c453b224cbcb89c3b3698f3ef6d
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+UUID:5D622F48- TCGA-UZ-A9PK-01A-PR Redacted SURGICAL PATHOLOGY REPORT Patient Nam Accession #: Med. Rec.#: Visit #: Service Date: DOB: Sex: Male Received: Soc. Sec. #: Location: Client: Physician(s): FInal Pathologic DIagnosis A. Left kidney, "anterior mass", excision: Papillary renal cell carcinoma with multiple small papillary neoplasms in adjacent kidney; see comment. B. Left kidney, Gerotas fascia adjacent to mass, excision: No tumor identified. C. Left kidney, "perimass fat", excision: No tumor identified D. Left kidney, "tumor mass #2", excision: Oncocytoma with multiple small papillary neoplasms in adjacent kidney; see comment. E. Perirenal fat: No tumor identified. F. Left kidney tumor mass #3, excision: Papillary renal cell carcinoma with capsular disruption and multiple small papillary neoplasms in adjacent kidney; see comment. tcD 63 rcinoyD ,feeycllby renaeeQ 8QJ S.te. lel neey HOS 164.9 QS3|30114 Comment: All three tumor resection specimens contain multiple papillary neoplams. In parts A and F, the dominant tumors are composed of papillary excrescences lined by realatively small cuboidal to low-columnar cells with primarily clear cytoplasm. The epithelial cell nuclei are moderately enlarged and round to oval with small nucleoli. The papillae contain fibrovascular cores, some with prominant foamy macrophages. The histology is that of type I papillary carcinoma. Hemorrhage and psammoma bodies are seen throuphout the lesions. ln part A. at least four additional microfoci of papillary proliferations similar to the dominant mass cell carcinoma are seen in the adjacent grossly normal renal parenchyma. In part F, a l.2 cm dominant papillary renal cell carcinoma is seen in association with three additional microfoci of papillary prolierationsare seen in the adjacent renal parenchyma. In part C, a 0.8 cm dominant mass composed of nests of cells with eosinophilic granular cytoplasm and Page 1 of 3
+
+--- Page 2 ---
+small round nuclei with prominant nucleoli is seen in association with two microfoci of papillary neoplasia. While the the minute papillary proliferations fall short of the size criterion for the diagnosis of papillary. renal cell carcinoma (they are < 5 mm in diameter) their histolgic resemblence to the definitive foci of papillary renal cell carcinoma and the finding of multifocal papillary renal cell carcinoma suggest that these small lesions may have more in common with papillary carcinoma than with isolated small tumors of the type that are called adenomas. In part F, the renal capsule adjacent to the dominant tumor is disrupted, however, it is not clear that this is tumor capsular penetration as oppsed to artifact associated with specimen handling and transport. Select slides were shown at the departmental and the faculty in attendance concurred with the above diagnoses. Kidney Tumor Synoptlc Comment -Histologic type: Renal cell carcinoma, papillary (chromophil) type (type I). -Grade: 2 -Maximum tumor diameter: 2.7 cm. -Site within kidney: Multifocal. -Renal pelvis: Not present. -Ureter: Not present. -Renal sinus: Not present. -Hilar renal veins: Not present. -Intrarenal veins and lymphatics: Normal, no tumor. -Adrenal gland: Not present. -Capsule/perirenal fat: Tumor does not penetrate capsule. -Hilar lymph nodes (number positive/number of nodes): N/A. -Resection margins: Negative. -Proximity to nearest margin: O.l cm (part A) -Stage: pT1NXMX. Specimen(s) Recelved A:Anterior mass of left kidney B:Jerotas C:Perimass fat D:Left kidney tumor mass #2 E:Perirenal fat F:Left kidney tumor mass #3 Clinical History The patient is a  year-old man with a left renal mass. He undergoes partial nephrectomy Gross Description The specimen is received in formalin in six parts, each labeled with the patient's name and medical record number. Part A is additionally labeled "anterior mass left kidney.* It consists of a single fragment of brown renal. tissue, notable for a single nodular mass protruding from the capsular surface. The specimen measures 3.5 x 3.0 x 2.4 cm. The mass measures 2.7 x 2.4 cm and protrudes above the capsular surface 1.1 cm. The surface of the mass is partially covered by a thin, translucent membrane, which is partially retracted The specimen is unoriented. The kidney resection margin is inked with black ink. The specimen is serially sectioned, revealing a hemorrhagic, partially cystic mass that appears to infiltrate the renal cortex. The mass approaches to within 1 mm of the black-inked margin. The specimen is entirely submitted in cassettes A1 through A7. Page 2 of 3
+
+--- Page 3 ---
+Part B is additionally labeled *Gerota's, ink marks area adjacent to mass, suture marks external margin." It consists of an irregular fragment of lobulated, yellow, adipose tissue, measuring 7.5 x 3.5 x 1.5 cm. Opposing sides of the roughly flat tissue fragment are partially epithelialized; one side is inked with purple ink, and the other is marked with a black suture. These represent the sides adjacent to the tumor and external surface, respectively. The inked surface is notable for focal areas of fibrous nodularity. The. sutured surface is glistening, smooth, and unremarkable. The specimen is inked as follows: inked surface is re-inked with blue ink, and the sutured surface is inked with black ink. Representative sections are submitted as follows: Cassettes B1-B2: Region of slight nodularity in the area of heaviest initial surgical inking.. Part C is additionally labeled "peri-mass fat renal tumor." lt consists of a single discoid fragment of lobulated, yellow, adipose tissue, measuring 6.0 x 4.0 x 1.2 cm. One surface is notable for a roughly circular fragment of fibrous membrane, measuring 3.0 x 2.5 cm. The surface of the membranous structure is smooth, glistening, and without lesions. The membrane area is inked with black ink. The specimen is serially sectioned, revealing unremarkable lobulated, yellow, adipose tissue. A representative section is submitted in cassette C1. Part D is additionally labeled "left kidney mass #2." It consists of a single roughly spherical fragment of tan-brown, soft tissue, measuring 1.5 x 1.5 x 1.4 cm. The tissue consists of a fragment of renal tissue and capsule surrounding a variegated tan and red-brown mass that projects above the renal surface a distance of O.6 cm. The specimen is not oriented. The surgical margin is inked entirely with black ink. The specimen is serially sectioned, revealing a punctate, cystic, hemorrhagic cut surface with focal areas of bright-yellow material located peripherally. The specimen is entirely submitted in cassettes D1 through D3. Part E is additionally labeled "prerenal fat." It consists of a single irregular fragment of lobulated, yellow fat and associated gray-white, fibrous membrane as well as some adherent red-brown material, suspicious for clot. The specimen is entirely submitted in cassette E1. Part F is additionally labeled "left kidney tumor mass #3." lt consists of three fragments of tissue. The largest fragment is tan/red-brown renal parenchyma, measuring 2.5 x 1.5 x 1.0 cm. A portion of renal surface with disrupted capsule is present and is notable for a single somewhat dome-shaped lesion, measuring 1.2 x 1.0 cm and projecting approximately 0.3 cm above the renal surface. The lesion is. variegated red-brown and yellow. The surgical margin is inked with black ink. The specimen is serially sectioned, revealing a somewhat granular, tan-yellow lesion that irregularly infiltrates the subjacent renal cortex. The specimen is entirely submitted in cassettes F1 through F3. The additional two tissue fragments are red-brown and tan, unoriented, irregular tissue, measuring 1.5 x 1.0 x 0.4 cm in aggregate. The tissue appears to represent fibrous tissue as well as blood clot. This tissue is entirely submitted in cassette F4. Diagnosis based on gross and microscopic examinations. Final diagnosis made by attending pathologist following review of all pathology slides. Pathology Resident Pathologist Electronically signed out on( Page 3 of 3
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+zCDo-3 UUID:47C78D8F -581E-4C91-AD2A-6C00F6EF5128 TCGA-P3-A5Q6-01A-PR Redacted 867df3 Sute path. CJsxesoFsxo CO9.I CLF $neel NoS C09.9 94/12113 COLLECTED: RECEIVED: CLINICAL DATA: Composite resection for left tonsil squamous cell carcinoma. GROSS DESCRIPTION: A) Received in formalin designated level IA is a 3.5 x 3.0 x 1.0 cm portion of fibrofatty tissue. Lymph nodes are dissected and submitted in the following cassettes: A1 - five possible lymph nodes; A2 - four possible lymph nodes; A3 - three possible lymph nodes. B) Received fresh designated  left selective neck dissection, double long level IIB, single stitch level IV is a 13.0 x 3.5 x up to 2.0 cm portion of fibrofatty tissue. A 3.0 x 1.0 cm portion of vein is present beginning at the inferior aspect of level II and extending to level III. Adjacent to the vein is a 2.5 cm nodule. Sections are submitted in the following cassettes: B1 - four. possible level IIB nodes; B2 - two possible level IIB nodes, one bisected and inked black; B3 - two possible level IIA nodes, one bisected and inked black; B4 - six possible level IIA nodes; B5 - grossly positive node with adjacent vein; B6 - three possible level III nodes, one bisected and inked black; B7 - three possible level III nodes; B8 - five possible level IV nodes; B9 - three possible level IV nodes. C) Received in formalin designated left submandibular gland is a 4.2. x 3.0 x 2.0 cm lobulated portion of tan tissue consistent with salivary gland. Sectioning demonstrates lobulated parenchyma with no gross lesions. Representative sections are submitted in cassettes C1 and C2. D) Received in formalin designated left facial node  is a 1.0 cm nodule, which is bisected and entirely submitted in cassette D1. E) Received in formalin designated left lingual nerve  is a 0.3 cm portion of pale tan soft tissue, which is wrapped and. entirely submitted in cassette E1. F) Received fresh designated peristyloid tissue is a 0.4 x 0.1 x 0.1 cm portion of pink soft tissue, which is entirely submitted for frozen section evaluation, thawed, and subsequently submitted in cassette FFS1. G) Received fresh designated left composite resection, single short stitch uvula, double short left tongue, and single long hard palate mucosa is a 5.5 x 4.3 x 4.0 cm resection specimen. The uvula is present at the right posterior aspect of the specimen indicated by a single short stitch. A double stitch is present on the anterior left aspect, indicating the hard palate mucosa. A double short stitch indicates the tongue where there is a bundle of skeletal muscle at the inferior aspect of the specimen. The left. lateral aspect is partially covered by skeletal muscle. The mucosa, which forms the medial aspect of the specimen, has an irregular ulcerated lesion spanning at least 2.5 cm superior to inferior x 1.7 cm anterior to posterior. The specimen is inked as follows: Superior and inferior black. anterior and lateral yellow, medial blue, posterior green. Sectioning demonstrates that pale tan,. firm tissue infiltrates throughout the entire specimen and closely approaches all surgical margins. Sections are submitted in the following cassettes: G1 - uvula; G2 - hard palate mucosal margin; G3 - tongue mucosal margin; G4, G5 - horizontal cross section with lateral, anterior, posterior and medial margins; G6, G7 - horizontal cross section inferior aspect of specimen; G8 - lesion in relation to inferior margin. H) Received in formalin designated level V node  is a 2.0 x 1.0 x 1.0 cm portion of fibrofatty tissue. Lymph nodes are dissected and submitted in the following cassettes: H1 - one nodule, bisected; H2 - remaining fatty tissue. I) Received in formalin designated styloid process is a 1.5 x 1.5 x 1.0 cm portion of fibrofatty tissue. The specimen is. serially sectioned demonstrating focal bone within the specimen. The entire specimen is submitted in cassettes I1 and I2 after brief decalcification. INTRAOPERATIVE CONSULTATION: FFS: Markedly cauterized biopsy with single nest of cauterized atypical epithelium versus nerve; cannot rule out squamous cell carcinoma, final diagnosis deferred.
+
+--- Page 2 ---
+FINAL DIAGNOSIS: A-D, H) Lymph nodes, level 1A, left selected neck, submandibular gland, left facial node, level. 5 node, dissections: 1. Metastatic carcinoma present in four of 34 lymph nodes: 0/7 level IA, 0/4 level IIB (see below), 1/8 level IIA, 2/8 level III, 1/5 level IV, 0/2 left facial, 0/1 level IV. 2. Foreign body giant cell reaction within one of the level IIB nodes suggestive of reaction to necrotic tumor. 3. Submandibular gland with no evidence of carcinoma.. E) Left lingual nerve, biopsy: Large nerve fascicle with no evidence of carcinoma F) Peristyloid tissue, biopsy: Atypical cells suspicious for carcinoma.. G) Left tonsil fossa, composite resection: Squamous cell carcinoma with the following 1. 5.0 cm greatest dimension. 2. Moderately to poorly differentiated. 3. Carcinoma infiltrates salivary glands and skeletal muscle (including tongue). 4. Carcinoma is extensively present at the cauterized superior aspect of the lateral surgical margin (G2), focally at the cauterized posterior margin (G6), closely approaching the. inferolateral margin (G8), less than 0.1 cm to the medial uvula margin, and 0.4 cm from the medial tongue margin. H) Styloid process, excision: Carcinoma present in soft tissue; adjacent bone uninvolved. COMMENT: Minimum pathologic stage: pT4aN2bMX (AJCC 2002) Procedures used to establish the diagnosis: I Submit tissue for decalcification. ADDENDUM REASON: This addendum is issued to report the size of the involved lymph nodes (all from part B) and the presence of extracapsular extension for the purpose of a clinical trial enrollment. It was also noted that one of the level designations (part H, in bold below) and the total number of nodes was incorrect in the final diagnosis. The remaining parts remain unchanged. The corrected diagnosis with the additional requested information is as follows: A-D, H) Lymph nodes, level 1A, left selected neck, submandibular gland, left facial node, level 5 node, dissections: Metastatic carcinoma present in four of 35 lymph nodes: 0/7 level IA, 0/4 level IIB (see below), 1/8 level IIA, 2/8 level III, 1/5 level IV, 0/2 left facial, 0/1 level V. Foreign body giant cell reaction within one of the level IIB nodes suggestive of reaction to necrotic tumor. Submandibular gland with no evidence of carcinoma. The largest positive node is 2.5 cm (level III) measured grossly. The three other positive nodes (level IIA, III, and IV) are. approximately 1.5 cm, 1.2 cm and 1.1 cm based on microscopy. Both level III nodes and the level IIA node have extracapsular extension.
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+
+--- Page 1 ---
+UUID:C4C7D190-F0EC-4A70-8136-534EA3419217 TCGA-A2-A0YF-01A-PR Redacted Chint of Fatholoyy Phone Fax Spacimen: Received: Status: SOUT Spec Type: SURGICAL P Subm Dr: PREOPERATIVE DIAKNCSA: BREAST CANCER IN SITU/NIPPLE DISCHARGE/LT BREAST MACROMASTIA OPERATION PERFCRHE! DATEt DOCTOR(S) : PROCEDURE: BIOPSXSXCISION AENTINLNODEDEERAXIIARY TISSUE REMOVED /cs-0-3 mfttutnq duct nos 8500f3 Carcioma, A. LT BREAST TISSUE RT SIMPLE MASTECTOMY Pam C.  RT AXILLA SENTINEL NODE #1 1/27/1 lu CqcF Sit: bAut nss C5o.9 PART A RECEIVED FRESH LABELED LEFT BREAST TISSUE, IS A LEFT BREAST TISSUE, IS A 643.5 GRAMS OF FIBROFATTY BREAST TISSUE AND SKIN SUBMITTED IN 2 PIECES, ONE IS A PORTION OF SKIN WITH AREOLAR TYPE TISSUE AT ONE END AND THE SECOND IS SKIN AND UNDERLYING FIBROFATTY TISSUE REMOVED IN A BREAST REDUCTION PATTERN. SECTIONING REVEALS BLAND YELLOW FATTY TISSUE WITH FINE FIBROUS BANDS AND NO AREAS OF MYELOFIBROSIS OR MASS IS IDENTIFIED. REPRESENTATIVE TISSUE IS SUBMITTED AS FOLLOWS: A1--SKIN TISSUE SUPERIOR, A2--MEDIAL ARM, A3 THROUGH A5--LATERAL ARM FROM SUPERIOR TO INFERIOR. PART B RECEIVED FRESH LABELED RIGHT SIMPLE MASTECTOMY STITCH 12 O'CLOCK, IS A SIMPLE MASTECTOMY SPECIMEN MEASURING 21 X 21.5 X 6.6 CM.  THE NIPPLE IS UNREMARKABLE. WITHIN A 21.2 X 12.5 CM SKIN ELLIPSE, A SUTURE DENOTES 12 O'CLOCK.  THE SUPERFICIAL ASPECT IS MARKED WITH BLUE INK, THE DEEP MARGIN WITH BLACK INK. A WELL-HEALED SCAR IS NOTED ON THE LATERAL ASPECT OF THE BREAST SKIN MEASURING 5.O CM IN LENGTH. SECTIONING REVEALS BLAND YELLOW FATTY TISSUE WITH FINE FIBROUS BANDS IN THE MIDPORTION. BLUE DYE IS NOTED. THERE IS AN AREA-OF GRAY FIBROSIS WITH TAN-BROWN DISCOLORATION SUGGESTIVE OF A PREVIOUS BIOPSY SITE IN THE UPPER OUTER QUADRANTS. THERE IS A FIRM NODULE IN THE 9 O'CLOCK LATERAL ASPECT OF THE SPECIMEN WITH FOCAL BLUE DYE SUGGESTIVE OF A LYMPH NODE.  THIS IS 1.1 CM FROM THE DEEP MARGIN. SECTION IS SUBMITTED IN B2 (MIRROR IMAGE TO PROTOCOL). THE AREA BETWEEN THIS BIOPSY SITE IS 5 CM FROM THE DEEP MARGIN.  BIOPSY CLIPS ARE NOT OTHERWISE IDENTIFIED WITHIN THE SPECIMEN. SECTIONS ARE SUBMITTED AS FOLLOWS: B1--NIPPLE AND SKIN SCAR, B2--POSSIBLE LYMPH NODE AT 9 O'CLOCK AREA, B3--DEEP MARGIN TO B2, B4--DEEP MARGIN TO PREVIOUS BIOPSY SITE, B5 THROUGH B12--SECTIONS OF THIS PREVIOUS BIOPSY SITE WITH B7 AND B12 THE FARTHEST FROM EACH OTHER AT 2 CM SPA, B13--NODULARITY IMMEDIATELY DEEP TO B12, UPPER OUTER QUADRANT, B14--UPPER OUTER QUADRANT IMMEDIATELY ADJACENT TO B13. B15--LOWER OUTER QUADRANT IMMEDIATELY INFERIOR TO B2, B16--RANDOM LOWER OUTER QUADRANT 6 CM FROM PREVIOUS BIOPSY SITE, B17--NODULARITY 6 O'CLOCK AREA 9 CM FROM PREVIOUS BIOPSY SITE (MIRROR IMAGE TO PROTOCOL), B18--LOWER INNER
+
+--- Page 2 ---
+Phone Yax at.en. Specimen Received: Status: Spec Type: SURGICAL P Subm Dr: GROSS DESCRIPTION (Continued) QUADRANT, B19--UPPER INNER QUADRANT. SEPARATELY SUBMITTED WITHIN THE CONTAINER IS A SMALL FRAGMENT OP YELLOW FATTY TISSUE MEASURING 3.5 X 3.0 X 1.2 CM IN GREATEST DIMENSION. THIS IS GROSSLY UNREMARKABLE AND REPRESENTATIVE TISSUE IS SUBMITTED IN B20. PART C RECEIVED FRESH LABELED  RIGHT AXILLA FIRST SENTINEL NODE HOT AND BLUE, IS YELLOW-TAN FATTY TISSUE MEASURING 3.4 X 2.0 x 1.0 CM.  SECTIONING REVEALS A GROSSLY UNREMARKABLE FAT-REPLACED NODAL TISSUE SUBMITTED ENTIRELY LABELED C. VTR PROCEDURRS PROCEDURES : 88305, 88307/2, IMMUNOPEROXIDAS, A BLK/5, B BLK/20, CBX X6 FINAL DIAGNOSIS PART A LEFT BREAST, REDUCTION MAMMOPLASTY: 1. CONSISTENT WITH MACROMASTIA. 2. SCATTERED FOCI OF ATYPICAL LOBULAR HYPERPLASIA. PART B RIGHT BREAST, SIMPLE MASTECTOMY: 1. MODERATELY DIFFERENTIATED INTRADUCTAL AND INPILTRATING DUCT CARCINOMA. THE INVASIVE COMPONENT SHOWS NUCLEAR GRADE 3, MODERATE MITOTIC INDEX AND TUBULE FORMATION 3 FOR A TOTAL NOTTINGHAM SCORE OF 7. DCIS OF THE CRIBRIFORM AND PAPILLARY TYPES, NUCLEAR GRADE 2 HAS RARE FOCI OF INTRALUMINAL NECROSIS AND COMPRISES APPROXIMATELY SO% OF THE TUMOR. 1 2. THE TUMOR IS MULTIFOCAL IN THE UPPER OUTER QUADRANT WITH THE LARGEST INVASIVE FOCUS MEASURING 7 MM IN GREATEST DIMENSION. ADDITIONAL INVASIVE FOCI ARE ALSO PRESENT THAT RANGE FROM 2 TO 3 MM IN GREATEST DIMENSION. DCIS IS IDENTIFIED ON 15 OF 20 BLOCKS EXAMINED HAVING A MAXIMUM CALCULATED DIMENSION OF 6 CM. 3. THE NIPPLE SKIN, RANDOM SECTIONS OF REMAINING QUADRANTS AND MARGINS ARE PREE OF TUMOR. LYMPHOVASCULAR INVASION IS NOT IDENTIFIED. 4. 5. THE BIOPSY SITE IS PRESENT. PART C  RIGHT AXILLA, SENTINEL LYMPH NODB BIOPSY: METASTATIC BREAST CARCINOMA IS IDENTIFIED IN THE SUBCAPSULAR SINUS/CORTEX IN A FOCUS MEASURING O.17 MM IN GREATEST MICROSCOPIC DIMENSION ON THB CYTOKERATIN STAIN WHICH WERE NOT SEEN ON INITIAL H AND E EXAMINATION.  RARE
+
+--- Page 3 ---
+Chtet ot ratbology Phone Fax ( enc Specimen: Received: Status: Spec Type: : SURGICAL P Subm Dr: FINAL DIAGNOSTS (Continued) ADDITIONAL ISOLATED TUMOR CELLS ARE ALSO PRESENT. Signed (prelim.) (signature on file)
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diff --git a/output/text/48ca8a70-903f-4add-b82b-22d25512e642.txt b/output/text/48ca8a70-903f-4add-b82b-22d25512e642.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0e8ac933c67abbde4d4ab0c8b4af4896f77ac860
--- /dev/null
+++ b/output/text/48ca8a70-903f-4add-b82b-22d25512e642.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+Clinical Diagaosis a History: Right breast cancer - Dcis. Right mastectomy and sLnB +/- axillary clearance. Specimens Submitted:  SP: Sentinel node #1, level 1, right axilla SP:  Sentinel node #2, level 1, right axilla 3: SP: Sentinel node #3. level 1, right axilla 4: SP: 9 Sentinel node #S. 5: SP:  level 2, right axilla Sentinel node #4, 6, and 2 9, 10, 11 and 12 zight axilla, levels 1 6: sp: Non sentinel tissue right axilla 7: sp: Right breast DIAGNOSIS: 1} SENTINEL NODE #I, LEVEL I. RIGHT AXILLA; EXCISION: - ONE BENIGN LYMPH NODE (O/1). - ADDITIONAL H&E STAINED SECTIONS AND IMMUNOPEROXIDASE STAINS FOR CYTOKERATINS (AE1:AE3) SHOW NO EVIDENCE OF METASTATIC CARCINOMA. 2) SENTINEL NODE #2, LEVEL I, RIGHT AXILLA; EXCISION: -ONE BENIGN LYMPH NODE (O/1. - ADDITIONAL H&E STAINED SECTIONS AND IMMUNOPEROXIDASE STAINS FOR CYTOKERATINS (AE1:AE3) SHOW NO EVIDENCE OF METASTATIC CARCINOMA. 3) SENTINEL NODE #3, LEVEL I, RIGHT AXILLA; EXCISION: EJ005.8 ONE BENIGN LYMPH NODE (O/1).  ADDITIONAL H&E STAINED SECTIONS AND IMMUNOPEROXIDASE STAINS FOR CYTORERATINS (AEI:AE3) SHOW NO EVIDENCE OF METASTATIC CARCINOMA. :qIn 4) SENTINEL NODE #S, LEVEL II, RIGHT AXILLA; EXCISION: "fttfo! sy - THREE BENIGN LYMPH NODES (0/3). SENTINEL NODES #4,6,7,8,9,10, 11,12, LEVELS I AND II, RIGHT AXILLA; EXCISION: EIGHT BENIGN LYMPH NODES (O/3). 6) NON-SENTINEL LYMPH NODES. RIGHT AXILLA; EXCISION: - THREE BENIGN LYMPH NODES (O/3). b 050 *+ Continued on next page ** SON fon9 ;yJS -0-0
+
+--- Page 2 ---
+7 7) BREAST, RIGHT;) TOTAL MASTECTOMY: - INVASIVE DUCTAL CARCINOMA, NOS TYPE, HISTOLCGIC GRADE III/III (SLIGHT OR NO TUBULE FORMATIONJ WETH PAPILLARY ARCHITECTURE; NUCLEAR GRADE III/III (MARKED VARIATION IN SISE AND SHAPE), MEASURING 4.3 CM IN LARGEST DIMENSION GROSSLY. - DUCTAL CARCINOMA IN SITO (DCIS) IS ALSO IDENTIFIED, SOLID TYPE, WITH HIGH NUCLEAR GRADE AND EXTENSIVE NECROSIS. - LOBULAR INVOLVEMENT BY DCIS IS PRESENT. - THE DCIS CONSTITUTES <2St OF THE TOTAL TUMOR MASS AND IS PRESENT ADMIXED WITH THE INVASIVE COMPONENT. - THE INVASIVE CARCINOMA IS LOCATED IN THE UPPER-OUTER QUADRANT. - THE DCIS IS LOCATED IN THE UPPER-OUTER QUADRANT. - NO INVOLVEMENT OF THE NIPPLE BY EITHER IN SITU OR INVASIVE CARCINOMA IS IDENTIFIED. - CALCIFICATIONS ARE PRESENT IN BOTH THE IN-SITU AND INVASIVE CARCINOMA - NO VASCULAR INVASION IS NOTED. - NO INVOLVEMENT OF THE SURGICAL MARGINS BY SITHER INVASIVE OR IN SITU CARCINOMA IS IDENTIFIED. - NO SXIN INVOLVEMENT SY CARCINOMA IS IDENTIFIED. THE SKIN SHOWS A SCAR.  THE NON-NEOPLASTIC BREAST TISSUE SHOWS BIOPSY SITE AND SECRETORY ChAngEs THE LYMPH NODE STATUS IS AS FOLLOWS (EXPRESSED AS THE NUMBER OF POSITIVE LYMPH NODES IN RELATION TO THE TOTAL NUMBER OF LYMPH NODES EXAMINED) : 0/1. - RESULTS OF SPECIAL STUDIES ARE AS FOLLOWS: ER: NO NUCLEAR STAINING). PR:  NO NUCLEAR STAINING). HER-2/NEU (HERCEPT TEST) : NEGATIVE (STAINING INTENSITY OF 1+). I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON NY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. **. Report Electronically Signed Out *. Special Studies: Result Special Stain AE1:AE3 Corment NEG CONT IMM RECUT AE1:AE3 NEG CONT IMM RECUT AE1:AE3 Neg cONt IMM RECUT eR-c ++ Continued on next page -
+
+--- Page 3 ---
+Z PR-C HER2-C NEG CONT NEG-HER2 IMM RECUT ER-C pR-C hER2-c NEG CONT IMM RECUT NEG-HER2 Gross Desc ription 1). The specimen is received fresh for frozen section consultation, labeled "Sentinel node numbex one. level 1. right axilla" and consists of a piece of. fatty tissue measuring 3.2 x 1.6 x 0.6 cm. A 1.0 cm lymph node is iduntified which is bisccted and entirely submittod for frozen section. Sunmary of sections:. Fsc -. frozen section control. 2).The specimen is received fresh for frozen section consultation, labeled *sentinei node number two level 1 right axilla* and consists of a tan lymph. node measuring 0.5 cm. Entirely submitted fox frozen section.. Sumary of sections:. Fsc -- frozen section control 3).The specimen is received fresh for frozen section coasultation, labeled "sentinel node number three. leval i right axilla" and consists of a tan lymph node measuring 1.0 cm. Bisected and entirely submitted for frozen section. Sucmary of sections:. Fsc -- frosen section control. 4).The specimen is received fresh for frozen section consultation, labeled *sentinel node number five lovel 2 right axilla* and consists of three tan lymph nodes measuring 0.2. 0.2. and 0.3 cm. Entirely submitted for frozen section. Summary of  sections: * Continued on next page *
+
+--- Page 4 ---
+rosen section control 5). The specimen is received in formalin, lubeled "Sentinel node number 4. 6, 7, 8, 9, 10. 11, and 12, right axilla levels one and two" and consists of. multiple unoriented pieces of fatty tissue totaling 3.7 x 3.5 x 0.9 cm in aggregate. Sectioning through the tissue reveals approximately 3 pink-tan lymph nodes ranging in size from 0.2 to 1.2 cm in greatest dimension. Iymph nodes are submitted entirely. The Sumnary of sections: U-undesignated 6). The specimen is received in formalin, labeled "Non-sentinel tissue, right axilia- and consists of two irregularly shaped unoriented pieces of yellow-tan soft lobulated tissuo measuring 5.5 x 4.9 x1.2 cm greatest dimension. Sectioning through the tissue reveals a rim of pink tan focally hemorrhagic lymphoid tissue measuring 1.5 x 0.3 cm. bisected and entirely submitted. Tho lymphoid tissue is. Sumwary of sections: U-undesignated 7). The specimen is received fresh labeled, "Right breast, stitch marks axillary tail" and consists of a breast measuring 22 x 21 x 6.8 cm with overlying white-tan skin ellipse measuring 15.s  4.7 cm. Situated centrally on the skin surface is a slightly retracted nipple measuring 0.8 :. 0.7 cm and areola measuring 2.8 x 2.5 cm. measuring of 2.i cm, situated at the lateral aspect of the skin surface. The skin shows a linear scar Suture demarcates the axillary aspect, which is inked blue.. Surface of the breast is inxed blacx. reveal an ill-detined white-tan, partially psoudoencapsulated. bulging.. The specimen is serially sectioned to  The posterior focally hemorrhagic tumor mass measuring 4.3 x 4 x 4.5 cm, located 0.7 cm. from the deep margin of excision at the outer upper quadrant. through the mass reveals a 2.5 x 1.7 x 2 cm smooth walled pink-tan hemorrhagic area at the medial edge of the mass consistent with a possible Cut section previous biopsy site. Cut sections through the mass reveal ill-defined areas. Of necrosis and fine granularity. areas of dense white tan fibrocystic tissue with multiple areas of pink-tan. The remaining tissue reveals well-defined nodularity idantified scattered throughout the tissue. Sectioning of the axillary aspect reveals a single 1.4 cm tan lymph node.. sections are submitted to tps. and for permanent section.  Representative Surmary of sections: N - nipple NB - nipple base S - skin scar D  deep margin  tumor UIQ upper inner quadrant . Continued on next page *.
+
+--- Page 5 ---
+LIQ - lower inner quadrant 5 UOQ  - upper outer quadrant. Page5 of  LOQ lower outer quadrant BLN . bisected axillary lymph node, entirely submitted Sumnary of Sections: Part i: sp: Sentinel node #1. level 1, right axilla Block Sect. Site 1 PCs fsc 1 Paxt 2: SP: Sentinel node #2. level 1, xight axilla Block Sect. Site 1 fsc PCs Part 3: SP: Sentinel node #3, level 1, right axilla Block Sect. site 1 pCs fsc 1 Part 4:  SP: Sentinel node #5. level 2, right axilla Block Sect. site 1 PCs fse 1 Part 5: SP: Sentinel node #4, 6, 7, 8, 9, 10, 11 and 12 right axilla, levels 1 and 2 Block Sect. Site PCs u 2 Part 6: SP: Non sentinel tissue right axilla 3lock Sect. Site PCs u 1 Part 7: SP: Right breast Block Sect. Site PCs bln 1 1 2 loq nb 1 uiq * Coatinued on next page
+
+--- Page 6 ---
+Procedures/Addenda: Addendum Date Ordered: Date Complete: Status:  Sianed Out Date Reported: By: Addendum Diagnosis ADDENDUM REPORT SITE: RIGHT BREAST (PART #7 ) A TUMOR TISSUE BLOCX DIFFERENT FROM THE ONE USED PREVIOUSLY. THE RESULTS REMAIN UNCHANGED. Intraoperative Consultation:. The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS: PERMANENT DIAGNOSIS: SENIgN.  Same. 2) FROZEN SECTION DIAGNOSIS: PERMANENT DIAGNOSIS: BENIGN. SAME. 3) FROZEN SECTION DIAGNOSIS: PERMANENT DIAGNOSIS: BENIGN.  SAME . FROZEN SECTION DIAGNOSIS: PERMANENT DIAGNOSIS: BENIGN.  SAME . ++ End of Report **
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diff --git a/output/text/48d7da2a-c230-4627-93bf-c291ef472ddc.txt b/output/text/48d7da2a-c230-4627-93bf-c291ef472ddc.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5bb1a17bf595b72b1ae8abf5ff4e64ff0bd4d5c4
--- /dev/null
+++ b/output/text/48d7da2a-c230-4627-93bf-c291ef472ddc.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Path (First Tumor) Tumor Site: Cecum Proximal 3 Date of Cancer Sample Procurement: Histology: Adenocarcinoma Description of other histology: Grade: Poorly Differentiated C Yes 6 No C Yes C Unknown Mucinous: (Focal) C Yes  No r Yes Signet Ring Feature: r Unknown (Focal) Histologic Heterogeneity:. 6 No r Yes ~ Unknown Host Response: None Crohn's like reaction  None r Yes C Unknown Plasma cell rich stroma. C No r Yes C Unknown  Expansile Growth Pattern:  Expansile  Invasive ~ Unknown and Invasive Inflammatory Bowel Disease 6 No C Yes C Unknown Angiolymphatic Invasion:. 6 No ( Yes  Unknown Mutator Phenotype: 6 No ( Yes ^ Unknown Number of Slides 2 C Yes Gartand Necrosis present: r No 6 Yes C Unknown (Focal) TIL Cells / HPF Pathologist Comment: /cs-0-3 sdiroCurcinoma Nos 8/40/3 UUID: 9DA1FAC8-4D16-4F59-A283-6E5093034816 Site: cecum c18.0 TCGA-DM-A28H-01A-PR Redacted 5/3/1 Cary Tumor Site Ccirc
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diff --git a/output/text/48def6d1-dab2-4381-aef3-6522bc9d4419.txt b/output/text/48def6d1-dab2-4381-aef3-6522bc9d4419.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4ce230fd52553039df2e777f6fa5d2321b83ccd0
--- /dev/null
+++ b/output/text/48def6d1-dab2-4381-aef3-6522bc9d4419.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+JUID:89307 -48AB-AC70-E16D89256DFC TCGA-OR-A5LJ-01A-PR Redacted tcDo-3 Tumor, Atrenal Corticc! Of unknownJincetain behavio. 83703 Procedure: most likely adrenalectomy. Site : Adrnal Claud cortex C74.D Reference Pathology only:. JtO 21|13 Diagnosis: adrenocortical carcinoma, 2 per 10 hpf P^ns -1f cs pusss ni ct mu puh. nuy nut shipi+nf alinnrnt,
+
+--- Page 2 ---
+Patient # from Tissue Source Site. Date of report Date of Surgery/specimen collection. Site (confirmed to be adrenal) with laterality indicated Tumor size(s) Histologic diagnosis ACC Lymph Node Status  Pathologic  information Weiss score
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diff --git a/output/text/48fc7cde-e81a-435d-9565-4dbbf34c8daa.txt b/output/text/48fc7cde-e81a-435d-9565-4dbbf34c8daa.txt
new file mode 100644
index 0000000000000000000000000000000000000000..598c449e2e820b7fce3157c67a03e667553e1b65
--- /dev/null
+++ b/output/text/48fc7cde-e81a-435d-9565-4dbbf34c8daa.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+ccD-o-3 Carcino ina. adrena! &rtical UUID:92EE5592-2CEC-4F7C-BF7B-A0A2CEE5E169 8370|3 -A5LN-01A-PR edacted Si+e, BAdrenal Clavd corfe. C?4D ND x/v/3 Procedure: Right adrenalectomy. Gross description: tumor is 168g; measuring 8.3 x 7 x 4.5cm Diagnosis: Adrenal cortical carcinoma. Weiss score = 6. No lymph node metastasis.
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diff --git a/output/text/49548054-3a09-48c9-8473-c24f9dca6440.txt b/output/text/49548054-3a09-48c9-8473-c24f9dca6440.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d2413d87e1a238c799ae0ca964d000b3a6b3b0b4
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Other Related Data: Billing Type: Financial Number: Clinical Diagnosis & History: Right renal tumor. Specimens Submitted: 1: SP: Right kidney (  2: SP: Paracaval lymph nodes DIAGNOSIS: 1) KIDNEY,: RIGHT; NEPHRECTOMY: RENAL CELL CARCINOMA, CLEAR CELL TYPE WITH FOCAL SPINDLE CELL FEATURES, NUCLEAR GRADE III/IV. - THE PATTERN OF GROWTH IS SOLID.  THE TUMOR'S GREATEST DIAMETER IS 8.O CM. FOCALLY, THE TUMOR EXTENDS THROUGH THE RENAL CAPSULE BUT IS CONFINED WITHIN GEROTA'S FASCIA.  NO INVASION OF THE RENAL VEIN IS IDENTIFIED. -ALL SURGICAL MARGINS ARE FREE OF TUMOR.  ANGIOMYOLIPOMA, SMOOTH MUSCLE PREDOMINANT (O.6 CM; SEE NOTE). THE ADRENAL GLAND IS NOT SUBMITTED. NOTE: IMMUNOHISTOCHEMICAL STUDIES OF THE ANGIOMYOLIPOMA ARE POSITIVE FOR SMA, FOCALLY POSITIVE FOR HMB-45 AND NEGATIVE FOR S-1OO PROTEIN. 2) PARACAVAL LYMPH NODE; RESECTION:  NINE BENIGN LYMPH NODES (O/9). Gross Description: 1) The specimen is received fresh for frozen section, labeled,. "Right kidney". It consists of product of right radical. nephrectomy which weighs 490 grams and measures 14.0 from Page 1 of 3
+
+--- Page 2 ---
+superior to inferior, 8.5 cm from medial to lateral and 5.5 cm from anterior to posterior. The soft tissue margins are inked blue. The specimen is bivalved revealing a fleshy mass in the superior pole which measures 8.0 x 6.5 x 3.0 cm. Portions of the tumor are yellow-orange and lobulated. In other regions, the tumor is homogenous, tan and firm. Approximately 25% of the tumor is composed of yellow-orange tumor and approximately 75% of the tumor has a homogenous tan appearance. Soft tissue margins are freely movable over the mass. The remaining renal parenchyma is tan-brown and unremarkable. The cortical thickness measure between 0.4 and 0.6 cm in thickness. The capsule strips with ease over the unremarkable parenchyma but is focally adherent in the region of the tumor. There is a 7.0 cm segment of ureter attached. The tumor does not involve the medullary cavity. The renal vein and artery are free of tumor. On serial sectioning, in the anterior aspect in the inferior pole, is a small, firm white nodule which measure 0.6 cm in greatest dimension.  This distinct nodule is located about 1.5 cm from the main tumor. Serial sectioning of the remaining of the large tumor mass reveals areas of hemorrhage and variable areas of necrosis. Examination of the hilar adipose tissue reveals no lymph nodes. Summary of Sections:. FSc - frozen section control T - tumor RP - renal parenchyma N -nodule VM - vascular margin UM - ureteral margin 2) The specimen is received in formalin, labeled, "Paracaval Lymph Nodes". It consists of a fragment of adipose tissue, measuring 4.0 x 2.2 x 1.5 cm. Cut-section shows a few lymph nodes, the largest measuring 2.5 cm in diameter. The larger lymph node is bisected.. The specimen is submitted in three cassettes. Summary of Sections:. BLN - bisected lymph nodes LN - lymph nodes Histo Stain Results/Comments: Stain/Procedure Name. Result Comment SMOOTH MUSCLE ACTIN MELANOMA-E (HMB-45) S100 PROTEIN IMMUNO RECUT NEGATIVE CONTROL MELANOMA-E' (HMB-45)  NEGATIVE CONTROL Summary of Sections: Part Sect. SiteBlocks Pieces  All Page 2 of 3
+
+--- Page 3 ---
+1 FSC 1 N N 1 1 RP 1 1 T 6 m UM 1 1 VM 1 1 2 BLN m N 1 LN 2 Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS: RENAL CELL CARCINOMA. PERMANENT DIAGNOSIS: SAME. Page 3 of 3 END OF REPORT
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diff --git a/output/text/495f08d0-9bae-47d1-904c-1bb8d36e2aee.txt b/output/text/495f08d0-9bae-47d1-904c-1bb8d36e2aee.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c95e4995457902d5ad1d393aae80b4bc7906e5f5
--- /dev/null
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+
+--- Page 1 ---
+FINAL DIAGNOSIS: Part 1: breast, left, 2 O'clock, segmental mastectomy - A.  InVasiVe DUctal CarcinQmA, nOs type, with mIcrocalcIFications. B. NOtTinghAm GRADE: 1 (tuBULE fORmAtiOn - 2, nUCLEAR PLEOmORphISm ~ 2, mITOtIC AcTIvIty  1, TOTal SCOre: 5/9). C. THE INVASIVE TUMOR MEASURES 2.1 CM IN LARGEST DIMENSION (SLIDE 1B). D. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 2, CRIBRIFORM TYPE. E. DCIS CONSTITUTES 10% OF TOTAL TUMOR MASS AND IS PRESENT ADMIXED WITH THE INVASiVE COMPONENT. F. NO LYMPHOVASCULAR SPACE INVASION IS NOTED (SEE COMMENT #1). G. RESECTION MARGINS ARE NEGATIVE FOR iNVASIVE CARCINOMA OR DCIS, INVASIVE COMPONENT IS 0.7 CM AWAY FROM THE CLOSEST (POSTERIOR) MARGIN (SEE COMMENT #2). H. LOBULAR CARCINOMA IN SITU (LCIS) AND ATYPICAL LOBULAR HYPERPLASIA (SEE COMMENT #3). I. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES WITH DUCTAL EPITHELIAL HYPERPLASIA COLUMNAR CELL CHANGE, APOCRINE METAPLASIA AND SCLEROSING ADENOSIS WITH MICROCALCIFICATIONS.  THe InVASIVe TUMOR CELLS ARE POSITIVE fOR ESTROGEN AND PROGESTERONE RECEPTORS AND . NEGATIVE FOR HER-2/NEU, AS PER PREVIOUS PATHOLOgY REPORT ( PART 2: AXILLA, LEFT NUMBER ONE SENTINEL LYMPH NODE, EXCISION - ONE LYMPH NODE, NEGATIVE FOR CARCINOMA (0/1) (SEE COMMENT #4). part 3: AxilLA, Left number TwO Sentinel Lymph nOde, eXcisiOn - ONE LYMPH NODE, NEGATIVE FOR CARCINOMA (0/1). PARt 4: AxILLA, LEft numbeR threE SenTinel Lymph nOde, EXciSIOn -- Two lymph nodes, negative for carcinoma inios. CASE SYNOPSIS: 1cs-0-3 SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST Cauima,mfi/taHng duhl, Nos 85oof3 LATERALITY: Left C50.9 3/1/n h PROCEDURE: Segmenta! LocatIOn: Upper outer quadrant SizE Of TumOR: Maximum dimension invasive component: 2.1 cm. MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: No TUMOR TYPE (invasive component): Ductal adenocarcinoma, NOS  NOTTInGHAm SCORE: Nuclear grade: 2 Tubule formation: 2 Mitotic activity score: 1 UUID:A76A272F-675E-4E56-8761-96B71419A0120 Tota! Nottingham score: 5 TCGA-BH-A0HQ-01A-PR Redacted Nottingham grade (1, 2, 3): 1 ANGIOLYMPHATIC INVASION: No DERMAL LYMPHATIC INVASION: Not annlicahle CALCIFICATION: Yes, benign zones TUMOR TYPE, IN SITU: Yes, malignant zones Cribriform DCIS admixed with invasive carcinoma LCIS Percent of tumor occupied by in situ component: 10 %. SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No SURG MARGINS INVOLVED BY IN SITU COMPONENT:E Distance of invasive tumor to closest margin: 7 mm LYMPH NODES POSITIVE: No LYMPH NODES EXAMINED: 0 METHOD(S) OF LYMPH NODE EXAMINATION: 4 ONLY KERATIN POSITIVE CELLS ARE PRESENT:E  H/E stain, Keratin stain NON-NEOPLASTIC BREAST TISSUE: ALH, FCD Yes t Stage, pathologic: N Stage, pathologic: pT2 m stage, pathologic: pN0(i+) ESTROgEn RECePTORS: pMX PROGESTERONE RECEPTORS: positive positive HER2/NEU: zero or 1+
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diff --git a/output/text/498af998-7ab5-4fb1-9d74-611a86cbc0fd.txt b/output/text/498af998-7ab5-4fb1-9d74-611a86cbc0fd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ee3718b88df3ea0d40e50dcedf09972b33129838
--- /dev/null
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@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+Cucar Case Repore (For Coilection of Cancerous Tissue) Informed Consent I personally informed this natient that a specimen(s) would be' collected to be used for research purposes. I reviewed the RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Clinical Information GENERALINFORMATIONSAS Marita! Status Race Temperature Gender Weight Blood Pressure Heart Rate  S HISTORY OF PRESENT ILLNESS Symptoms: Wss W ei oy Clinical Findings: Performance Scale (Karnofsky Score):  100 Asymptomatic  80-90 Symptomatic but Fully Ambulatory  60-70 Symptomatic, in bed less than 50% of day.  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden.   20-30 Bed Ridden SCURRENT MEDICATIONS EDSSRAS Drug Dose Route Frequency Date (mm/dd/yyyy) To To / To / / To / To
+
+--- Page 2 ---
+SAPASTMEDICAL HISTORY Diagnosis/Disease/Disorder/Injury Diagnosis Date Treatment Status SOCIALHISTORY Occupation:  Environmental Hazards: Smoking History. Current Status TYPE  Packs/day Duration When Quit  YES *NO (yrs) (y) Alcohol Consumption Current Status TYPE Drinks/day Duration When Quit YES NO (yrs) (yr) Drug Use Current Status TYPE Frequency Duration When Quit  YES tPNO (yrs) (yr) SSFAMILYMEDICALHISTORYPSS Relative Diagnosis Age of Diagnosis. LABDATA Test Result Date Test Result Date HIV  Positive: CEA  Negative  Positive: Negative Hep B Negative  Positive: CA 15-3   Negative  Positive: CA 19-9   Negative  Positive: Hep C  Negative  Positive: AFP PSA  Positive:   Negative  Positive:   Negative Other: Other:   Positive:  Negative  Positive:  Negative B/T Cell Markers: 2
+
+--- Page 3 ---
+Study Results Date Ultrasound X-Ray CT MRI  Biopsy CLINICALDIAGNOSIS Preoperative Clinical Diagnosis Location of Suspected Involved Lymph Nodes Location of Suspected Distant Metastasis Clinical Staging Date of Diaanosis t3 no mo Stage: Treatment Information ESSSURGICAL TREATMENTEESA Procedure Date of Procedure 7 Primary Tumor Organ Detailed Location Size x x cm Extension of Tumor Lymph Nodes Location of Lymph Nodes # of Lymph Nodes Description Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Organ Detailed Location Size Surgical Staging No. mo Stage:7 NEOADJUVENT THERAPY ChemoRadiation Immuno Hormonal or Molecular  Date (mm/dd/yyyy) Drug/Treatment Dose Route Frequency To / To ! To / To / / To / 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by: Dat Time Preserved by:a Da Time SPECIMEN TYPE #of samples provided)  Frozen Paraffin Block  Blood/Serum/Plasma Slide Diseased Normal Diseased  Normal Diseased Normal Diseased  Normal 2 2 Z Time to LN2 Time to Formalin Time to LN2 A min min min PATHOLOGICALDESCRIPTION Primary Tumor Organ Size Extension of Tumor Distance to NAT C lom teman c x 3 x 2 cmASCeu dzcjq 6 cm Lymph Nodes Location # Examined # Metastasized Distant Metastasis Organ Detailed Location Size Pathological Staging pT 3 Na M o Stage: Notes:
+
+--- Page 5 ---
+Microscopic Description  Histological Patterne a Cell Distribution + Structural Pattern + Diffuse  Streaming  Mosaic  Storiform  Necrosis Fibrosis  Lymphocytic Infiltration  Palisading  Vascular Invasion  Cystic Degeneration  Clusterized  Bleeding  Alveolar Formation  Myxoid Change  Indian File  Psammoma/Calcification Cellular Differentiation Squamous + Adenomatous + Sarcomatous + Lymphomatous  Squamoid Cell Glandular cell  Round Cell Large Cell Spindle Cell Cell Stratification Fibroblast Small Cell  Keratin Secretion Osteoblast  RS Cell/RS Like Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell  Pearl  Gland formation Myoblast  Plasma Cell Cellular Differentiation: Well Moderate Poor Nuclear Atypia: 0 1 II III Aniso Nucleosis Hyperchromatism  Nucleolar Prominent Multinucleated Giant Cell  Mitotic Activity Nuclear Grade:  Marker  Result Value Date ER  Negative  Positive PR  Negative   Positive Her-2/neu  Negative  Positive B-Cell Marker  Negative  Positive T-Cell Marker  Negative  Positive Other:  Negative  Positive Other:  Negative  Positive Final Pathology Report 0c/enocorcj`sima o1 tR Coln Histological Diagnosis: Meeetqtohe olilekeoritaied Grade: Comments: Pathologist 5
+
+--- Page 6 ---
+CONSOLIDATED DIAGNOSTIC PATHOLOGY FORM* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION Diffuse + STRUCTURAL PATTERN X Streaming Mosaic Storiform Necrosis Fibrosis Lymphocytic Infiltration x  Palisading  Vascular Invasion X Cystic Degeneration Clusterized Bleeding... Alveolar Formation XI  Myxoid Change Indian File Psammoma/Calcification 2. Cellular features:  Squamous +. Adenomatous +  Sarcomatous + Lymphomatous  Squamoid Cell Glandular cell Round Cell  Large Cell Spindle Cell  Cell Stratification X Fibroblast Small Cel!  Keratin Secretion V Osteoblast RS CeIl/RS Like  Desmosome Intracyt. Vacuole  Lipoblast  Inflam. Cell Pear!  Gland formation Myoblast Plasma Cell Otherwise Specified: D( (0)e Drs0% S. : 5OZ D4 s0Z - NQ0QAos 2. Cellular Differentiation: Well Moderately  Poor X 3. Nuclear Atypia: Nuclear Appearance I1  Aniso Nucleosis Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity X Nuclear Grade Ao(esocesergog 4) Histological Diagnosis: Comments Date ATHOLOGIST STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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diff --git a/output/text/49a9f0d5-4a01-48ff-87f0-e4ed5412b561.txt b/output/text/49a9f0d5-4a01-48ff-87f0-e4ed5412b561.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9be000e837f2d9eb3a8ec7c3fa0d09415a4e43a9
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+
+--- Page 1 ---
+Surgical Pathology TCGA-DZ-6131 TISSUE DESCRIPTION: Right kidney (15 x 8 x 6.0 cm) with attached 34.5 cm segment of. ureter (together weigh 345 grams), and separately submitted right precaval lymph node. DIAGNOSIS : renal cell. carcinoma,forming a 7.2 x 6.0 x 5.2 cm mass in the upper. pole of the kidney. There is extension into perirenal fat. The ureteral and soft tissue margins are uninvolved. The collecting. system is uninvolved. Lymph nodes, right precaval, excision: A single right precaval lymph node is negative for tumor.
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diff --git a/output/text/49da9616-5874-4f28-894b-9f26eefb4645.txt b/output/text/49da9616-5874-4f28-894b-9f26eefb4645.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a226097d58b59eff776c8aeb24f73764124c26cb
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+
+--- Page 1 ---
+SURGICAL PATHOLOGY REPORT Accession number: Final Report DIAGNOSIS: 1) TONGUE, RIGHT VENTRAL, EXCISION: MODERATELY DIFFERENTIATED KERATINIZING SQUAMOUS CELL CARCINOMA; PERINEURAL INVASION PRESENT. **Electronically Signed Out by CLINICAL DATA Clinical Features: Unspecified Operator: Operation: Unspecified Operative Findings: Unspecified. Operative Diagnosis: Unspecified. Tissue Submitted: 1) right ventral tongue. GROSS DESCRIPTION: 1) SOURCE: Right Ventral Tongue. Received fresh in a container labeled "right ventral tongue" are two pink. soft tissue fragments that in aggregate measure 1.0 cm x 0.3 cm x 0.3 cm. The specimen is entirely submitted in cassette 1A. Summary of sections: 1A, 2/1. Dictated by Slides and report reviewed by Attending Pathologist..
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diff --git a/output/text/49fabaf8-47fa-4915-aaad-d6b216488964.txt b/output/text/49fabaf8-47fa-4915-aaad-d6b216488964.txt
new file mode 100644
index 0000000000000000000000000000000000000000..76cef2c08e1397a1efe492738281b22c8e86540a
--- /dev/null
+++ b/output/text/49fabaf8-47fa-4915-aaad-d6b216488964.txt
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+
+--- Page 1 ---
+ID-O:3 UUID:C8915232-ED02-4AE9-9BB0-283EAD2610AB TCGA-5P-A9K2-01A-PR Redacted Carcivona, papillary nrc? 8&c0/3 C64.9 fJ6/13/!4 Papillary Renal Cell Carcinoma, Type II Stage: pT1b, RO Grade: GIII Latera bws/4/14
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diff --git a/output/text/4a16d32c-b688-4c6f-b68e-04a0e60a5efb.txt b/output/text/4a16d32c-b688-4c6f-b68e-04a0e60a5efb.txt
new file mode 100644
index 0000000000000000000000000000000000000000..aaa259022e7574fbe0c4f4907e9ea3900ca5d600
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+TcD-o-3 Corcnns, riral ce0l JID:5329DF1E-4818-4D68-8ED2-F9D136536300 Redacted Chrsmoprslie type 83/7/3 Sit OKiduy NoS Ce49 Surgical Pathology Report. XO 9/24/13 Diagnosis: A: Periaortic lymph nodes. - Four lymph nodes, negative for malignancy (0/4) - Prominent non-caseating granulomatous inflammation in one lymph node; special stains for microorganisms (AFB and GMS) are negative - See comment B: Left kidney. Histologic tumor type/subtype: renal cell carcinoma, eosinophilic variant of chromophobe carcinoma;. See comment Sarcomatoid features: None identified Histologic grade (if applicable): Fuhrman grade 3 of 4. Tumor size (greatest dimension): 7.0 cm Tumor focality: Multi-focal: largest tumor 7.0 cm, smaller microscopic tumor focus 0.2 cm in greatest dimension Extent of tumor invasion (if present specify if macroscopic or microscopic): Capsular invasion/perirenal adipose tissue: Negative for malignancy; see comment Gerota' s fascia: Negative for malignancy. Renal sinus: Negative for malignancy Major veins (renal vein or segmental branches, IVC): Negative for malignancy Ureter: Negative for malignancy Venous (large vessel): Absent Lymphatic (small vessel): Present. Histologic assessment of surgical margins: Gerota' s fascia (nephrectomy): Negative for malignancy Renal vein (nephrectomy): Negative for malignancy. Ureter (nephrectomy): Negative for malignancy Adrenal gland: Not sampled. Lymph nodes: Please see specimen A
+
+--- Page 2 ---
+Other significant findings: Angiomyolipoma (1.0 cm in greatest dimension) AJCC Staging: pT1b pN0 Comment: The findings in the lymph node (biock A1) are suspicious for sarcoidosis. Correlation with clinical and laboratory finding is recommended. Specimen B is a challenging diagnosis. Microscopic examination demonstrates a neoplasm consisting of tumor cells with occasional bizarre nuclei surrounded by extensive amounts of eosinophilic cytoplasm. Neither mitoses nor necrosis are identified, but Fuhrman grade 3 nuclei are seen. The capsule is compressed by tumor, but definitive capsular invasion is not identified. Immunohistochemical stains are performed and demonstrate the tumor is positive for E-Cadherin and cD117 with focal positivity for EMA and CD10 while being negative for vimentin, renal cell carcinoma and CK7. These immunohistochemical findings are not entirely definitive, but, when combined with the histologic features, are most consistent with the eosinophilic variant of chromophobe carcinoma. Dr. has reviewed specimen B on this case and concurs with the above diagnosis. Clinical History:. year-old female with renal mass. Gross Description: The specimen is received in two parts labeled A and B. Specimen A is received in formalin and labeled with the patient' s name and "periaortic lymph nodes." The specimen consists of multiple irregularly shaped fragments of yellow/brown rubbery soft tissues that have an aggregate measurement of 4.0 x 3.5 x 2.0 cm. Embedded within the soft tissue are four semi-ovai shaped tan lymph node candidates that range in size from 0.5 x 0.5 x 0.5 cm up to 1.8 x 1.8 x 0.6 cm in greatest dimensions. The cut surface of the largest lymph node candidate is yellow/gray and without gross necrosis. Block Summary: A1 Large individual bisected lymph node candidate, entirely submitted. A2 Three individual lymph node candidates, entirely submitted. Specimen B is received in formalin and labeled with the patient' s name and "left kidney." The specimen has been previously triaged, and consists of a bisected kidney measuring 14.0 x 7.5 x 5.5 cm and weighing 280 grams. The left adrenal gland is surgically absent. Specimen orientation is not provided. The renal capsule is intact. A large, bosselated, tan-brown subcapsular mass (5.0 x 4.0 cm in greatest. dimensions) is present involving the upper pole; the capsule surface overlying the mass is inked black prior to sectioning. After sections are taken from the anterior and posterior inked capsule surface, the capsule is removed and strips with ease. The inferior pole cortical surface is tan/brown and there is. slight retention of fetal lobulation. Upon further examination of the cut tumor surface, the entire upper pole is replaced by a fairly weil-circumscribed, tan/brown mass that measures 7.0 x 6.0 x 4.5 cm in
+
+--- Page 3 ---
+greatest dimensions; several small cystic areas containing dark red fluid are noted along one periphery of the tumor that range in size from a few millimeters up to 0.5 x 0.5 cm in greatest dimensions. The  tumor obliterates the entire upper pole collecting system and extends inferiorly to the interface of the pelvicaliceal junction, and is situated within 7.5 cm of the ureteral surgical margin of resection. The grossly uninvolved pelvis is narrowed and the mucosal surface is gray-white, smooth and glistening.. Calculi are not present. The corticomedullary junction of the inferior pole is well-defined; the cortex measures O.8 cm in thickness. The inferior pole pyramids are gray-white with prominent medullary rays; a few papillae have pale yellow discoloration. Additionally, situated 4.5 cm from the previously. described tumor mass along the inferior pole anterior cortical surface is a well circumscribed, pale yellow nodule that measures 1.0 x 1.0 cm in greatest dimensions; the cut surface of the nodule is soft to firm, homogeneous pale yellow, and extends into the parenchyma for a distance of 1.5 cm. The attached segment of ureter measures 2.7 cm in length and 0.9 cm in circumference; the mucosa is velvety, pale gray and the lumen is widely patent. Separately submitted in the same container is a portion of pale yellow adipose tissue that measures 28.0 x 20.0 x 4.5 cm in greatest dimensions. The cut surface is homogeneous pale yellow and grossly. unremarkable. Also submitted in the same container is a single white tissue cassette containing discoid shaped  segments of the hilar vasculature and ureteral surgical margins of resection that appear grossly unremarkable. Block Summary: B1 Inked upper pole anterior capsule surface with associated tumor B2 Inked upper pole posterior capsule surface with associated tumor B3 Additional representative sections of upper pole anterior cortical surface and tumor B4 Additional representative sections of upper pole posterior cortical surface and tumor B5 Representative section of upper pole mass at the interface of the pelvocaliceal junction B6 Representative section of grossly normal renal pelvis B7 Representative sections of inferior pole renal pyramids with pale yellow papillary discoloration B8 Representative sections of ureteral and vascular surgical margins of resection received in white cassette 89 Representative sections of inferior pole pale yellow nodule h 8/34ff3
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diff --git a/output/text/4a29db2c-638b-4a54-b475-7b3c5350cf85.txt b/output/text/4a29db2c-638b-4a54-b475-7b3c5350cf85.txt
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index 0000000000000000000000000000000000000000..e1322d01c97b040499c70172a89d8eb959e83dc9
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+
+--- Page 1 ---
+UUID:7189A8A8-E88B-4795-B7FE-725CCC487FA7 TCGA-AN-A0AM-01A-PR Redacted TSS Patient ID Case #: DOB: Sex: Female Ethnicity (Race): 1 Cancer Samplea Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma Date of Procurement: Anatomic Site: Left Breast Tumor location: Primary. Tissue Specification: Tumor Specinen Matrix: Tissue Specimen Format: Frozen Container: cryomold Type of Procurement: Radical mastectomy Grade: 2 T Stage: 2 N Stage: 0 M Stage: 0 Treatment: none. Treatment Details: n/a  Normal Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw Matrix: Blood Specimen Format: frozen Container: tube. Date of Procurement: icD-0-3 carenomr, mfiltratr:cy duct,Nvs I5oof3 Site: brast, Nos C50.9
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diff --git a/output/text/4a7e45ad-6542-44ce-97db-6a54733ad707.txt b/output/text/4a7e45ad-6542-44ce-97db-6a54733ad707.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e3d02dc8417b04dbe330f7d3a6cc4514d0f8247b
--- /dev/null
+++ b/output/text/4a7e45ad-6542-44ce-97db-6a54733ad707.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+SURGICAL PATHOLOGY REPORT Clinical Diagnosis & History: RLQ tenderness,  cT scan revealed mass at hepatic flexure at colon and mass lymphoplasmacytic infiltration at lamina propria. Carcinoma of hepatic flexure with liver mass. Specimens Submitted: 1: Lymph node, base of superior mesentery artery, excision 2: Lymph node, middle colic, excision. 3: Colon, right, hemi-colectomy DIAGNOSIS: 1. Lymph node, base of superior mesentery artery, excision -Metastatic moderately differentiated adenocarcinoma in  one of two lymph nodes (1/2). 2. Lymph node, middle colic, excision. -One benign lymph node 0/1). 3. Colon, right, hemi-colectomy:. Tumor Type: Adenocarcinoma Histologic Grade: Moderately differentiated Tumor Location: Cecum Tumor Size: Length is 8 cm Width is 6 cm Maximal thickness is 1.8 cm. Tumor Budding: Extensive Increased Tumor Infiltrating Lymphocytes:. Absent Precursor Lesions: Not identified Deepest Tumor Invasion:. Subserosal adipose tissue and/or mesenteric fat Gross Tumor Perforation: ** Continued on next page **
+
+--- Page 2 ---
+Page 2 of 4 Not identified Lymphovascular Invasion: Identified Large Venous Invasion: Not Identified. Perineural Invasion: Identified Surgical Margins: Free of tumor Polyps/Mucosa Dysplasia (away from the carcinoma): Not Identified Non-Neoplastic Bowel: Unremarkable Appendix: Not identified.. Lymph Nodes: Number with metastasis: 12 Total number examined: 72 Tumor deposits in pericolorectal soft tissue: Identified Identified; number:1. Tumor Staging (AJcc 7th Edition): pT3 (Tumor invades through the muscularis propria into pericolorectal tissues) Lymph Node Stage (AJcc 7th Edition): N2b (Metastasis in seven or more regional lymph nodes) Note: Results of immunohistochemical staining for DNA mismatch repair. proteins are as follows:. MLHl: Staining present in tumor MSH2: Staining present in tumor MSH6: Staining present in tumor PMS2: Staining present in tumor Conclusion:Immunohistochemical staining for the tested DNA mismatch repair proteins is retained in the tumor. Some of the immunohistochemistry and Ish tests were developed and their performance characteristics were determined by the Department of Pathology.. Administration. The FDA has determined that such clearance or approval is. not necessary. These tests are used for clinical purposes. They should not. be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of (CLIA as qualified to perform high complexity clinical laboratory testing. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OFS THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. ** Continued on next page **
+
+--- Page 3 ---
+Page 3 of 4 *** Gross Description: 1. The specimen is received fresh for frozen section labeled "base of superior mesenteric artery lymph node" are two lymph nodes each measure 0.5. cm greatest dimension. The lymph nodes are entirely submitted for frozen section. Summary of sections: FSc-frozen section control 2. The specimen is received fresh for frozen section labeled "middle colic lymph node" is a 1.0 cm lymph node. The lymph node is bisected and entirely. summit of the frozen section. Summary of sections: FSC-frozen s section control 3). The specimen is received fresh, labeled "Right hemi-colectomy" and. consists of a segment of terminal ileum, cecum and ascending colon. The terminal ileum measures 14 cm in length and 3 cm in circumference at the. proximal resected margin. The remaining colon measures 40 in length with a circumference of 6 cm at the distal resected margin. The appendix is not present. The intestinal serosa is pink tan and smooth.  Focally hemorrhagic lobulated yellow tan adipose  tissue measuring up to 5 cm in thickness. The specimen is opened to reveal a circumferential mass lesion measuring 6 cm in length and 8 cm in width. The mass is located in the cecum,  23 cm from the proximal margin and 15 cm from the distal margin. Sectioning shows that the tumor invades the fat. The depth of invasion is 1.8 cm grossly. Right underneath the mass is a 4 x 2.5. x 2 cm conglomerate of five nodules with yellow/white cut surface (distance. from tumor surface to the deepest portion of the conglomerate is 4.8 cm).. The remaining mucosa is unremarkable. The specimen is submitted for lymph node dissection.  The attached adipose tissue is thoroughly examined and all identified lymph nodes are submitted. Representative sections of the. specimen are submitted for permanent sections and for Tps.. Summary of sections: P- proximal margin shave distal margin shave T - tumor RS -representative sections LN - lymph nodes BLN - bisected lymph nodes C - conglomerate of 5 nodes, representative section ** Continued on next page **
+
+--- Page 4 ---
+Page 4 of 4. Summary of Sections:. Part 1:  Lymph node, base of superior artery, Block Sect. Site PCs 1 FSC 1 Part 2: Lymph node, middle colic, excision Block Sect. site PCs 1 fsc Part 3: Colon, right, hemi-colectomy Block Sect.  Site PCs 5 BLN 1 c 1 1 1 10 LN 20 1 1 6 RS Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. Frozen Section Diagnosis: Base of superior artery lymph node Positive for metastatic adenocarcinoma. Permanent Diagnosis: SAME 2. Frozen Section Diagnosis: Middle colic lymph node Benign. Permanent Diagnosis: SAME ** End of Report .
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index 0000000000000000000000000000000000000000..29801b8c4f9062da85240fdb14a402487cfcaf57
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+
+--- Page 1 ---
+TCGA-CK-4947 Pathology Report Accession Number: o. Report Status: Final Type: Surgical Patholoay Pathology Report COLON, SEGMENTAL RESECT FOR TUMOR Accessioned On: . DIAGNOSIS: SPECIMEN LABELED "SIGMOID COLON (14.5 Cm)": ADENOCARCINOMA OF THE COLON, moderately differentiated (4.0 cm in greatest dimension). The tumor invades through the muscularis propria into pericolonic adipose tissue and is present at the serosal surface. Lymphovascular invasion is not present.. Non-neoplastic colonic mucosa with no significant pathologic change. Proximal resection margin is free of carcinoma. METASTATIC CARCINOMA in three (3) of twelve (12) 1ymph nodes. SPECIMEN LABELED "DISTAL COLON WITH MARGIN"; Distal resection margin is free of carcinoma.. AJCC staging: T4 N1 Mx CLINICAL DATA: History: Colon cA invading L ureter for palliative resection. Operation: Sigmoid colectomy, left ureterolysis - frozen section.. Clinical Diagnosis: sigmoid colon cancer, left ureteral stricture. TISSUE SUBMITTED: 1. Sigmoid colon - open end is distal. 2.  Distal colon with margin. O.R. CONSULTATION: SPECIMEN LABELED "1) SIGMOID COLON - OPEN END IS DISTAL" (GROSS ONLY): Circumferential lesion consistent with adenocarcinoma. The proximal and distal marqins are free of carcinoma. GROSS DESCRIPTION: The specimen is received in two separate containers, each labeled with the patient's name and medical record number.. Part one is designated "sigmoid colon open end is distal".  The specimen. consists of a single segment of colon (14.5 cm length x 3 cm diameter) with attached fat and mesentery (6.5 cm in maximum diameter). Distal resection marqin is 2.3 cm. Proximal resection margin is 2.2 cm. There is a circumferential. mass that measures 4 x 3 x 1.8 cm, appears grossly to invade through full thickness and causes serosal puckering.. This mass is present 4.5 cm to distal resection margin and 4 cm to proximal resection margin. Representative sections are taken for tumor bank. Representative sections are submitted for histologic evaluation. Micro 1-3: tumor at area of deepest invasion, 3 frags. Micro 4: tumor towards distal margin, 1 frag, Micro 5: tumor towards proximal resection margin,. frag. Micro 6: proximal resection margin, en face ? frags,  Micro 7: distal resection margin, 1 frag, Micro 8: 3 potential lymph nodes, 3 frags,. Micro 9: 4 potential lymph nodes, 4 frags,. Part two, received designated "distal colon with margin". The specimen consists of a single portion of colon (1 cm length x 3 cm diameter).  Stapled resection margin measures 4 cm in length. Resection margin is inked in black.. licro 10: stapled resection margin, en face, 2 frags, Reports to: SPECIMEN TYPE: COLON, SEGMENTAL RESECT FOR TUMOR ADDITIONAL SPECIMEN TYPE: SURGICAL MARGIN Page: 1 of 1
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diff --git a/output/text/4aa233ef-1ef3-41f4-8741-d04f75165005.txt b/output/text/4aa233ef-1ef3-41f4-8741-d04f75165005.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fa67d0bad71de54d2fc62b272b857a00bdbc318f
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+
+--- Page 1 ---
+TD 03 Site: CKiduwy NBS C44.9 DsJ a/13/14 UUID:096ABF46-EC92-4C6A-8D8F-05D48E8C2CA1 TCGA-5P-A9KF-01A-PR Slide of nephrectomy with two focal (2.2 and 0.6 cm) highly differentiated Papillary Renal Cell Carcinoma (Type 1) close to multiple papillary adenomas and chronic interstitial nephritis.. Classification pTNM 2010: Stage: pT1a (m=3) L0 V0 Pn0 Grade: G1 R-Classification:R1 ICD-O: 8260/3. Laterality :
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diff --git a/output/text/4af0805d-194f-4e86-a0eb-14d41ad49494.txt b/output/text/4af0805d-194f-4e86-a0eb-14d41ad49494.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1e3d85bc7e650a5050fd921858907c6cccdf1f4a
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+
+--- Page 1 ---
+UUID: EA8A0A91-7A83-4EC9-B7A0-0C3300D1FD14E TCGA-XX-A899-01A-PR zeiDD Redacted iyyustolirg dolulor areensro N6 s 8s20|3 cs0.9 Research Gross Description J0s08 year old female multifocal breast cancer Research Dx Procedure: Total mastectomy (including nipple and skin) Lymph node sampling: Sentinel Iymph node and axillary dissection Specimen laterality: Right Tumor site: Multifocal, lower outer quadrant (majority of tumors) and lower inner quadrant Tumor size: 2 x 1.5 x 1.3 cm (largest tumor) Histopathologic type: Lobular with foci of signet ring morphology 0% on +op sfide. Histopathologic grade (Nottingham): 2 Mitotic count: 2 mitoses/10 hpf (low proliferative rate) Tumor focality: Multiple foci of invasive carcinoma Pathologic tumor stage: pT1c: Tumor greater than 1 cm but less than or equal to 2 cm in greatest dimension Margin status: See below Distance of carcinoma from margins: Anterior: 0.35 mm (microscopic focus) Posterior: 8 mm. All other margins greater than 1 cm Associated in situ carcinoma: Yes Type: LCIS Extensive (>25% of total tumor): No.  Separate (extra-tumoral) foci away from main lesion: Yes Peritumoral angiolymphatic invasion: Not identified Dermal angiolymphatic invasion: Not identified  Hormone receptors by properly controlled immunohistochemistry performed on previous core biopsy Estrogen receptor: Positive Progesterone receptor: Positive HER-2/neu (ERBB2): Negative Pathologic lymph node stage: pN2a: Metastasis in 4-9 axillary lymph nodes (at least one tumor deposit greater than 2.0 mm) Number of nodes positive for metastasis/total number nodes sampled: 5/22 Maximum diameter of largest lymph node metastasis: 1 cm Extranodal extension by tumor: Present, focal. Distant metastasis: pM: Not applicable. Additional pathologic findings: Fibrocystic changes AJCC Staging (7th Edition): pT1c(m) pN2a pM: Not applicable Research QC Tumor: 80% tumor nuclei 0% necrosis 20% normal Normal: 100% breast
+
+--- Page 2 ---
+Specimen Process Time Blood draw time: Plasma frozen time: Serum frozen time: Buffy coat frozen time Cold ischemia start time: Formalin fixation start time: Total cold ischemia time: Formalin fixation stopped time: Total formalin fixation time: Specimen Weight  Normal 1-512 mg, 2-351 mg, 3-283 mg, 4-372 mg Tumor 1-262 mg, 2-205 mg, 3-208 mg, 4-317 mg Specimen Size Plasma x 3 Serum x 2 Buffy coat x 1 Cryovials x 8. Normal x 4 Tumor x 4: 1-2 lesion site A., 3-4 lesion site B. FFPE x 8 Normal x 4 Tumor x 4: 1-2 lesion site A., 3-4 lesion site B. Study Patient Consent Yes HPAA Discrepancy ual/Synchron aeis (circie): 2
+
+--- Page 3 ---
+Page 1 of 1 TCGA Pathologic Diagnosis Discrepancy Form 4.05  Study Subject ID: Person ID: N/A Study/Site: TCGA Breast Invasive Carcinoma - (Breast Invasive Carcinoma) Age: N/A Event: PathDiscrepancy Date of Birth: Interviewer: Sex: F Tumor Identifier Provided on Initial Case.  Provide the tumor identifier documented on the initial case quality Quality Control Form control form for this case.  Pathologic Diagnosis Provided Infiltrating lobular Provide the diagnosis/ histologic subtype(s) documented on the initial on Initial Pathology Report. carcinoma pathology report for this case. If the histology for this case is mixed, provide all listed subtypes. Histologic features of the sample provided for signet ring Provide the histologic features selected on the TCGA Case. TCGA, as reflected on the CQCF  morphology Quality Control Form completed for this case..  Discrepancy between Pathology Report and Case Quality Control Form Provide the reason for the pathology report reports the presence Provide a reason describing why the diagnosis on discrepancy between the pathology of signet ring morphology, however, the initial pathology report for this case is not report and the TCGA Case Quality the topslide contains 0% signet ring. consistent with the diagnosis selected on the TCGA Controi Form Case Quality Control Form.  Name of Tss Reviewing Pathologist or Provide the name of the pathologist who reviewed this. Biorepository Director case for TCGA.
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diff --git a/output/text/4b85d8ca-8133-49f7-8dde-0099b62a8b26.txt b/output/text/4b85d8ca-8133-49f7-8dde-0099b62a8b26.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2c72aad598490bf76daa5d40b0ae48b51673483c
--- /dev/null
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+
+--- Page 1 ---
+Diagnosis: Right hemicolectomy preparation with an ulcerated colon carcinoma characterized histologically as a moderately differentiated, partially mucinous, colorectal. adenocarcinoma, located 11.5 cm aborally to Bauhin's valve, and encircling the colon wall. at a length of 3.5 cm. Invasive spread of the tumor within all intestinal wall layers up to the bordering mesocolic fatty tissue. Oral and aboral resection margin and greater omentum are tumor-free. Appendix with clear post-inflammatory fibrosis of the wall.. Therefore the tumor stage is pT3, pN1 (2/24) L0 V0; G2 R0
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diff --git a/output/text/4bb35eb9-41ae-419d-89c3-a56caaafa3f4.txt b/output/text/4bb35eb9-41ae-419d-89c3-a56caaafa3f4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..853ea59b9b6cfba543810b62473d0e2d7a6189af
--- /dev/null
+++ b/output/text/4bb35eb9-41ae-419d-89c3-a56caaafa3f4.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+SURGICAL PATHOLOGYREPORT Patient Name: Accession #: Med.Rec.# Date of Procedure DOB: Date of Receipt: Gender: Date of Report Ref.Physician: Account#: Patient Address: Billing Type Additional Copy to: Ref.Source Clinical Diagnosis & History year old male with right renal mass. Specimens Submitted 1:SPRight renal tumor (fs) 2:SP:Deep surgical margin,right kidney 3:SP:Paracaval lymph node DIAGNOSIS: SP:Right renal tumor fs) Tumor Type: Renal cell carcinoma-Unclassified type High grade. See comment Tumor Size: Greatest diameter is 3.7 cm. This pertains to the largest tumor although multiple lesions are present.See comment Local Invasion (for renal cortical types): Not Identified Renal Vein Invasion: Not identified Surgical Margins: Tumor present at renal parenchymal margin (for partial nephrectomy specimens only) See comment Non-Neoplastic Kidney: Marked chronicinflammation and arteriolonephrosclerosis Adrenal Gland Not identified Lymph Nodes: Not identified Staging for renal cell carcinoma/oncocytoma: pT1 Tumor<=7.0 cm in greatest dimension limited to the kidney COMMENT: The tumors in this case exhibit a very unusual constellation of features that do not fit into any of our well defined categories.The main tumor mass is predominantly papillary and solid with focal tubular areas.It is high grade.Focal areas of necrosis are evident. In the adjacent renal parenchyma there are innumerable neoplastic foci that have tubular features and basophilic cytoplasm.These measure from 3 millimeters to less than 0.1 millimeter. It is these foci of disease that are present at Page 1 of3
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT the parenchymal margin of resection.The main tumor mass is immunoreactive for CK7 and focally for racemase.It is negative for CA9.The satellite nodules are immunoreactive for CK7 but negative for racemase. BAF-47 is not interpretable.The overall appearance is suggestive of a syndrome-associated tumor although the unusual morphology does not allow us to make this statement with confidence or to suggest the syndrome involved, if such is the case. Close examination of the contralateral kidney is advised Seen in consultation with Some of the immunohistochemistry and ISH testswere developed and their performance characteristics were determined by theDepartment of Pathology.They have not been clearedor approved by the US Food and Drug Administration.The FDA has determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for research.This laboratory is certified under the Clinical Laboratory Improvement Amendments as qualified to perform highcomplexity clinical laboratory testing. 2. SP:Deep surgical margin,right kidney: -Benign renal medullary parenchyma. SPParacaval lymph node 3. Lymph Nodes: Not involved Number of nodes examined:2 with focal granulomas IATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL).AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT Special Studies: Result Special Stain Comment RACEMASE CK7 CA-1X. BAF-47 NEG CONT IMM RECUT CK7 RACEMASE BAF-47 IMMRECUT NEG CONT Gross Description: 1) The specimen is received fresh for frozen section consultation and is labeled "Right renal tumor".It consists of a 4.5 x 4 x 4 cm wedge shaped portion of kidney with a suture marking the deep margin. The margin is inked black and the specimen is serially sectioned to reveal a tan white tumor with large areas of necrosis, measuring 3.7x 3.5 x2.5 cm.The clearance from the resection margin is 0.5 cm. A representative section of the nearest margin is submitted for frozen section diagnosis.Representatively submitted.Portions of the tumor are submitted for TPS Summary of sections: FSC-frozen section control T-tumor M-margin RS-representative sections Page 2of3
+
+--- Page 3 ---
+SURGICAL PATHOLOGY REPORT 2).The specimen is received in formalinlabeled "deep surgical margin right kidney"and consists of a 0.7 x 0.6 x 0.2 cm fragment of tan soft tissue.Entirely submitted. Summary of sections: U-undesignated 3).The specimen is received in formalin labeled "Paracaval lymph node" and consists of two pink tan firm lymph nodes with attached fatty fibrous tissue ranging from 0.3 cm up to 1.2 cm in greatest dimension.All identified lymph nodes are submitted. Summary of sections: LN-lymphnode BLN-bisected lymph node Summary of Sections Part 1:SP:Right renal tumor (fs) Block Sect.Site PCs 5 add 5 1 fsc 1 1 m 1 1 rs 1 5 t 5 Part 2:SP:Deep surgical margin,right kidney Block Sect.Site PCs 1 1 u Part 3:SP:Paracaval lymph node Block Sect.Site PCs 1 bin 1 1 In 1 Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 1) FROZENSECTION DIAGNOSIS: SP:RIGHT RENAL TUMOR (FS):LARGELYNECROTIC RENAL TUMOR MARGIN NEGATIVE. PERMANENT DIAGNOSIS:SAME Page 3of3 END OF REPORT
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diff --git a/output/text/4bb52b11-c3a1-4250-bd4a-735f1933d422.txt b/output/text/4bb52b11-c3a1-4250-bd4a-735f1933d422.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fc5f8c9b9a511fc185bdda842d2a2defa79f21f9
--- /dev/null
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+
+--- Page 1 ---
+FINAL SURgICAl PAThOLOGy rEPOrT Diagnosis: A. Left KIdney mass, parTial NephrectOmy: - Papillary renal cell carcinoma, Fuhrman nuclear grade 2. - Multifocal, largest focus 2.5 cm.. - Surgical margin POsiTivE at parenchymal cauterized margin. PATHOLOGIC TUMOR STAGING SYNOPSIS (KIDNEY): Type and grade: Papillary renal cell carcinoma, type I, Fuhrman nuclear. grade 2. Primary tumor: pT1a. Regional Iymph nodes: pNX Distant metastasis: pMX. Pathologic stage: I. Lymphovascular invasion: Not identified. Margin status: R1, cauterized parenchymal margin POsITIVE. B. , e., f.) prostate, new left lateral margin, new right Lateral MARGIN, RADICAL PROSTATECTOMy AND RE-EXCISION Of RIGHT AND LEFT LATERAL MARGINS: - Prostatic adenocarcinoma, Gleason score 3 + 4 = 7. - Largest tumor focus 1.7 cm (multifocal).. - Involves right and left prostate lobes. - Extraprostatic extension identified.. - Perineural invasion identified. - Surgical margin POsiTIVE at left bladder neck margin.. PATHOLOGIC TUMOR STAGING SYNOPSIS (Prostate): Type and grade: Prostatic adenocarcinoma, Gleason score 3 + 4 = 7.. Primary tumor: pT3a. Regional lymph nodes: pN0 (0/8, negative for metastatic carcinoma).. Distant metastasis: pMX. Pathologic stage: III. Lymphovascular invasion: Not identified.
+
+--- Page 2 ---
+FInal SurGiCAl PATHOlOGy rEPOrt PROSTATE TUMOR STAGING INFORMATION: (data derived from current specimen, staging in accordance with or modified from AJCC Cancer Staaina Handbook, 7th Ed, and CAP protoco!, Procedure: Radical prostatectomy. Specimen type: Prostate. Prostate size/weight:  3.7 x 3.5 x 3.4 cm. Tumor Features: Tumor site: Right and left prostate lobes. Tumor size: Largest focus is 1.7 cm, multifocal. Tumor quantification: 15% of prostate involved. Histologic type: Prostatic adenocarcinoma.. Histologic grade (Gleason pattern): Primary pattern: 3. Secondary pattern: 4. Tertiary pattern: N/A. Total Gleason score: 7. Lymphovascular invasion:. Not identified. Perineural invasion: Present. Extraprostatic extension: Present. Seminal vesicle invasion:. Not identified. Treatment effect: N/A. Lymph Nodes: Negative (0/8). Margin Evaluation: Distance to closest margin: Surgical margin positive at left bladder neck. Other margins: N/A. Pathologic tumor staging descriptors: Primary tumor (pT): pT3a. Regional lymph nodes (pN): pN0 (0/8). Distant metastasis (pM): pMX. Margin status (R): R1, positive at left bladder neck. Additional findings: High-grade prostatic intraepithelial neoplasia. Comment: On the original radical prostatectomy specimen. (part B), the right lateral margin is positive, however, the additional tissue submitted as right. Iateral margin (part F) shows no tumor, therefore the final margin of the right lateral margin is negative.
+
+--- Page 3 ---
+FINAL SuRGICAL PATHOLOGy REPORT Source of Specimen: A. Left Kidney Mass B. Prostatectomy C. Right lliac Obturator D. Left Iliac Obturator E. Left Lateral Margin F. Right Lateral Margin Clinical History/Operative Dx:. Left kidney mass, prostate cancer Gross Description: A. The specimen is labeled left kidney mass and is received without fixative. It consists of a cortical portion of kidney which overall measures 3.3 x 3.1 x 2.9 cm and.  The cortical surface of the kidney appears smooth with intact renal capsule. The surgical margin is inked. The specimen is serially sectioned to reveal a well circumscribed mass measuring 2.5 x 2.5 x 1.8 cm. This mass is variably composed of pale tan to granular reddish and hemorrhagic tissue. It abuts the cortical surface but there is no overlying perirenal fat. It is grossly 0.5 cm from the closest cortical resection margin. Representative sections of this neoplasm are obtained for research purposes. Also in the specimen container is a 4 cm aggregate of lobulated fatty tissue which is serially sectioned and contains no obvious tumor. Representative sections are submitted. Section summary: A1-A4) renal neoplasm and cortical resection margin, A5) peripheral section of neoplasm and representative separate fatty tissue. B. The specimen is labeled prostate and is received in formalin. It consists of a prostatectomy specimen which  The prostate gland measures 3.7 x 3.5 x 3.4 cm and includes a partially. disrupted 2.5 x 1.5 x 0.7 cm right seminal vesicle, a 1.7 cm segment of right vas deferens, a 1.7 cm segment of left vas deferens, and a short but intact appearing 1.8 x 1.3 x 0.9 cm left seminal vesicle. The right anterior surface of the prostate is inked blue, the left anterior surface is inked green, and the posterior surface is inked black. The prostatic apex, bladder neck, and seminal vesicle / vasa are trimmed. The prostate is divided into right and left halves and is sectioned from apex to bladder neck. The right apical portion of the prostate anteriorly displays pale yellow-tan discoloration in two discrete foci, each 0.7 cm in maximum dimensions. One of these areas is just adjacent to the apical portion of the prostate and the other is located in the mid gland. The prostatic gland parenchyma throughout the left prostate is spongy tan and fibrous. Representative sections are submitted. Section summary: B1) right prostatic apex, B2) left prostatic apex, B3) right bladder neck, B4) left bladder neck, B5) surgical margin right vas deferens, right seminal vesicle, B6) surgical margin left vas deferens, left seminal vesicle, B7-B24) prostate, apex- bladder neck C. The specimen is labeled right iliac obturator and is received in formalin. It consists of a 5.5 x 3 x 1.8 cm ovoid portion of fibrofatty tissue and a small 1.1 cm fragment of similar tissue. On dissection there is an ovoid partially fatty replaced 4.5 cm node. In the remaining tissue there is a 2.3 cm node, 1.2 cm
+
+--- Page 4 ---
+FInAl SurgiCAl pAThOLOGy rEpOrt fragment of nodal tissue, and three additional fragmented portions of nodal tissue varying from 0.8 - 1 cm in maximum dimension. On sectioning the largest node has a firm pale tan glistening appearance throughout. The smaller node and nodal fragments have a similar appearance. Representative sections of the largest node are submitted in cassettes C1-C2. The second largest node is bivalved and submitted in cassette C3. A single node is serially sectioned and submitted in cassette C4. Representative sections of the remaining nodal fragments are submitted in cassette C5. D. The specimen is labeled left iliac obturator and is received in formalin. It consists of a 7.2 x 2.8 x 1.5 cm ovoid portion of fibrofatty tissue. On dissection there is a large matted portion of nodal tissue measuring 6.5 x 2.7 x 1.5 cm. In the small amount of adherent fatty tissue are three 0.5 - 0.7 cm additional nodes. The largest matted set of nodes is serially sectioned and is composed of pale tan glistening uniform appearing tissue with a peripheral small amount of fatty tissue. Representative sections of the largest matted node are submitted in cassettes D1-D4. The smaller nodes are submitted in cassette D5 E. The specimen is labeled left lateral margin and is received in formalin. It consists of a 0.7 x 0.4 x 0.2 cm fragment of tan to reddish brown tissue with a metallic clip along one edge. The specimen is submitted in cassette E1. F. The specimen is labeled right lateral margin and is received in formalin. It consists of two metallic clips with a small amount of intervening red-brown soft tissue. The clips are removed and the intervening tissue is submitted in cassette F1. Microscopic Description: A. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered. B. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered. C. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered. Immunohistochemistry was performed and interpreted at for BCL-2, BCL- 6, CD10, CD3, CD20, CD23, CD5, CD21, cyclin D1, IHD, and Ki-67. Immunohistochemistry was performed at ProPath and interpreted at for ZAP 70. Sections show lymph node with effaced architecture with a pseudofollicular pattern of regularly distributed pale areas (proliferation centers) and a dark background of smaller cells. The tumor cells are positive for CD20, CD5, CD23, IgD, and Bcl-2 and negative for CD10, Bcl-6, cyclin D1 and CD3. CD3 stains background T cells. CD21 highlights rare follicular dendritic networks. Ki-67 shows increased staining in the proliferation center areas. The tumor cells are positive for ZAP70. No metastatic carcinoma is identified. No large cell transformation is identified. D. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered. Sections show an atypical small lymphoid proliferation histologically similar to that seen in part C.
+
+--- Page 5 ---
+FINAL SURGICAL PATHOLOGY REPORT E. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered. F. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered.
+
+--- Page 6 ---
+FINAL SUrGICAL PATHOLOgy REPORT Perineural invasion: Present. Margin status: R1, surgical margin POsitiVE at left bladder neck. C. - d). lymph nodes, iliac obturator, Right And Left, regional. Lymph NOde bIOpsIES:  - Small lymphocytic lymphoma/chronic lymphocytic leukemia, see comment. - Eight lymph nodes, negative for metastatic carcinoma (0/8). COMMENT (specimens C & D): Sections show an atypical small Iymphoid proliferation that is positive by immunohistochemistry for CD5, CD20 and CD23 and negative for. CD3, cyclin D1, and CD10, consistent with small Iymphocytic Iymphoma/chronic Iymphocytic leukemia. No large cell transformation is identified. The tumor cells are positive for ZAP-70 by immunohistochemistry. An intradepartmental consultation with. was obtained. Results discussed with. hours. Kidney Tumor Staging Information. (data derived from current specimen, staging in accordance with or modified from AJCC Cancer Staging Handbook, 7th Ed, and CAP protocol. Procedure: Partial nephrectomy. Specimen type: Partia! nephrectomy. Left. Specimen laterality: Tumor Features: 2.5 cm. Tumor size: Tumor focality: Multifocal. Papillary renal cell carcinoma, type I. Histologic type: Histologic grade (Fuhrman nuclear grade):. Fuhrman nuclear grade 2. Sarcomatoid features: Not identified. Macroscopic extent of tumor:. Limited to kidney. Microscopic tumor extension:. Tumor limited to kidney. N/A. Lymph Nodes: Margin Evaluation: Cauterized parenchymal margin POSITIVE Distance to closest margin: Peri-renal capsule margin negative. Other margins:
+
+--- Page 7 ---
+Final SurgiCal pathOlOgy rEpOrt Pathologic tumor staging descriptors: Primary tumor (pT):. pT1a. Regional Lymph nodes (pN): pNX. Distant metastasis (pM): pMX. Margin status (R):. R1, cauterized parenchymal margin POsITIVE. Pathologic stage: 1. Focal glomerulosclerosis, chronic inflammatory. Pathologic findings in non-neoplastic kidney:. cell infiltrate histologically similar to that seen in. patient's Iymph node (small B-cell lymphoma). Additional pathologic findings:. N/A.
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diff --git a/output/text/4bd27e7a-0bf3-47c1-bc5a-f0e00bd74004.txt b/output/text/4bd27e7a-0bf3-47c1-bc5a-f0e00bd74004.txt
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index 0000000000000000000000000000000000000000..fb2580b5c201c4b3e7c65ad3f506316bf20796ca
--- /dev/null
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+
+--- Page 1 ---
+to/ar UUID:1FB1255E-D9EC-4FE9-BE96-F81271 CGA-A1-A0SH-01A-PR Redacted ics-0-3 cuscioma, nifi1t^aHNq duct,Ncs 85oo/3 pu 1o/21f Sire: brast Nos C50.9 Final Pathologic Diagnosis: A. Lymph node, sentinel node #1, excision: No carcinoma (0/1). B. Lymph node, sentinel node #2, excision: No carcinoma (0/1). C. Breast, Ieft, partial mastectomy: 1. Invasive ductal carcinoma, sBR grade 2, 2.1 cm; see comment. 2. Ductal carcinoma in situ, sotid and micropapillary types, 1 cm; see comment. 3. Lobular carcinoma in situ, classic type; see comment. 4. Atypical ductal hyperplasia involving fibroadenoma.. Note: Breast Tumor Synoptic Comment - Laterality: Left. - Invasive tumor type: Invasive ductal carcinoma. - Invasive tumor size: 2.1 cm maximum diameter. - Invasive tumor grade (modified Bloom-Richardson): 2. Nuclear grade: 2, 2 points. Mitotic count: <10 mitotic figures/10 HPF, 1 point. Tubule/papilla formation: Definite tubule formation in <10%, 3 points. Total points and overall grade = 6,7 points = grade 2. - Lymphatic-vascular invasion: Present (Slide C11). - Resection margins for invasive tumor: - Deep margin: Negative; tumor is 3 mm away, on Slide C5.. - Medial margin: Negative; tumor is 5 mm away, on Sllde C11. - Lateral margin: Negative (widely clear, >1 cm). - Anterior/superior margin: Negative; tumor is 6 mm away, on Slide C10.. - Anterior/inferior margin: Negative (tumor is widely clear, >1 cm). - Ductal carcinoma in situ (Dcis) type: Solid-micropapillary.. - Ductal carcinoma in situ size: Page I of^6
+
+--- Page 2 ---
+Surgical Pathology - Working Draft - DCIS present in contiguous sections, 1 cm maximum diameter (Slide C10).. - Ductal carcinoma in situ nuclear grade: Intermediate grade.. - Necrosis in Dcis: Comedonecrosis, focal (<1/3). - Microcalcifications: None. - Resection margins for ductal carcinoma in situ: - Deep margin: Negative; tumor is <1 mm away, on Slide C13. - Medial margin: Negative; tumor is 1 mm away, on Slide C13.. - Lateral margin: Negative (widely clear, >1 cm). - Anterior/superior margin: Negative; tumor is <1 mm away, on Slide C13. - Anterior/lnferior margin: Negative (widely clear, >1 cm).. - Lobular carcinoma in situ (LcIs): Present. - Number of lobules involved: Few. - Nuclear type/size: Classic, small cell type. - Lymph node status:. - Number of positive lymph nodes: 0. - Total number sampled: 2. - AJCc/UICC stage: pT2N0(S)mX. - Nontumorous breast tissue: Atypica! ductal hyperplasia involving fibroadenoma. In Slide C11, a few lobules show round shaped nucleated cells with powdery blue vesicular cytoplasm. proliferating within Iobule Iumens. Immunohistochemistry for E cadherin is obtained and is necessary to evaluate these cells. The stain is negative in these areas and supports the diagnosis of Iobular. carcinoma in situ.. An immunohistochemical test for estrogen and progesterone receptors was performed on block C5 and C10. The test for estrogen receptors is negative. There is no nuclear staining in any tumor cells. Interna!. positive control is positive.. The test for progesterone receptors is positive. There is strong nuclear staining in >95% of tumor cells. Internal positive control is present. Result of HER2/neu test: This carcinoma is indeterminate for HER2/neu oncoprotein over-expression. An immunohistochemical assay was performed on block C5 using the CB11 monoclonal antibody to HER2/neu oncoprotein. The staining intensity of this carcinoma was 2 on a scale of 0-3. Carcinomas with staining intensity scores of 0 or 1 are considered negative for over-expression of HER2/neu oncoprotein. Those with a staining intensity score of 2 are considered indeterminate. We and others have observed that many carcinomas with stalning intensity scores of 2 do not show gene amplification. All carcinomas with staining intensity scores of 2 are therefore submitted for FIsH testing. The results of the FIsH test are issued directly from the moiecular cytogenetics laboratory. Carcinomas with stalning intensity scores of 3 are consldered positive for over-expression of HER2/neu oncoprotein. Tumors in this category show an excellent correlation between the results of Immunohistochemlcal and Fish testing, and almost always show gene amplification. Intraoperative Consult Diagnosis FS1 (A) Left axillary SLN #1, biopsy: No carcinoma in one lymph node (0/1). (Dr. FS2 (8) Left axillary SLN #2, biopsy: No carcinoma in one lymph node (0/1). (Dr. Clinical History The patient is a year-old woman with palpable lesion in the left upper inner quadrant. She now  Page 2 of 6
+
+--- Page 3 ---
+Working Draft Surgical Pathology - undergoes partial mastectomy. Gross Description The specimen Is received fresh in three parts, each labeled with the patient's name and medical record. number. consists of one piece of pink-yellow, Part A, additionally labeled fatty tissue measuring 2 x 1.4 x 0.7 cm. The specimen is trimmed, and one candidate lymph node is found, inked green and bisected, entirely submitted for frozen section diagnosis 1, and subsequently submitted in cassette A1. The remaining yellow, fatty tissue is entirely submitted in cassette A2. consists of one soft, tan-yellow, Part B, additionally labeled. fatty tissue fragment measuring 3 x 1.5 x 0.5 cm. The specimen is trimmed, and one candidate. !ymph node is entirely submitted for frozen section diagnosis 2, and subsequently submitted in. cassette B1. The remaining yellow, fatty tissue is entirely submitted in cassette B2. It consists of Part C is additionally labeled a yellow-white, fatty mastectomy specimen, measuring 3 (anterior to posterior) x 4.9 (medial to lateral) x 6.2 (superior to inferior) cm and weighing 21.3 gm. There is a yellow-white, firm, irreguiar mass, measuring 2 (anterior to posterior) x 2.1 (inferior to superior) x 1.5 (medial to lateral) cm, with a central stellate appearance abutting the anterior-superior and posterior margins; it is 1.5 cm from the anterior-inferior margin and 1 cm from the lateral and medial margins. The specimen is inked for. microscopic diagnosis so as the anterior-superior surface is blue, the anterior-inferior surface is green,. and the posterior surface is black. A portion of the tumor is taken for tissue banking. The specimen is serially sectioned into seven O.5-cm slices, from lateral to medial, and representative sections are. submitted as follows: Representative section of slice 1, lateral margin, perpendicular.. Cassette C1: Slice 2, superior portion. Cassette C2: Slice 2, inferior portion. Cassette C3: Tumor, slice 3, three pieces, superior to inferior. Cassettes C4-C6: Tumor, slice 4, two pieces, superior to inferior. Cassettes C7-C8: Tumor, slice 5, two pieces, superior to inferior. Cassettes C9-C10: Stice 6. Cassette C11: Cassettes C12-C13: Slice 7, medial margin, perpendicular.. /Pathologist /Pathology Resident Signed: : Fee Codes: Other Specimens Accessioned: Status: Signed Out ....Specimen Class: Signed Out: Specimen(s) Received: Cervical/Endocervical, Direct Final Diagnosis Cervical/Endocervical, Direct NEGATIVE FOR INTRAEPITHELIAL LESION OR MALIGNANCY. Atrophic pattern SpecImen ADequACy: Satisfactory for evaiuation. Transformation zone components are present. Paze 3 of6
+
+--- Page 4 ---
+Surgical Pathology Working Draft Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Peritoneal Washing Final Diagnosis. Peritonea! Washing BENIGN. Reactive mesothelial cells Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: A: Right ovary and tube (fresh), B: Left ovary and tube (fresh). Final Diagnosis A. Right ovary and faliopian tube, risk-reducing salpingo-oophorectomy:. - Ovary: Serosal calcifications, benign epithelial inclusion glands, adhesions and endosalpingiosis. - Fallopian tube: No significant pathologic abnormality. B. Left ovary and fallopian tube, risk-reducing salpingo-oophorectomy:. - Ovary: Serosal calcifications, benign epithelial inclusion glands, adhesions and endosalpingiosis. - Fallopian tube: No significant pathologic abnormality. QA Review(s) Immuno Problem? N Status: Complete as of Revlewers: Result(s): Informed Pathologist (Name):  Resolution(s):  Repeat extra slides available: repeat and make up p53. Reason(s): Immuno Stain - No Staining: no stain in p53 control. related specimen(s): Status: Signed Out Accessioned .Specimen Class: Signed Out: Specimen(s) Received: right breast capsule Final Diagnosis. Right breast, periprosthetic capsulectomy: Organizing granulation tissue.. MD mD Status: Signed Out Accessioned Specimen Class: Signed Out: Specimen(s) Received: Rectum, biopsy Final Diagnosis Rectum, biopsy: Focal cryptitis; see comment.. Paor d nf h
+
+--- Page 5 ---
+Surgical Pathology Working Draft Status: Signed Out Accessioned: Specimen Class: Signed Out: Specimen(s) Reccived: A: Lefl Breast, B: Lefl Nipple Aerolar Margin, C: Right Breast, D: Right Breast Aerolar Margin Final Diagnosis A. Left breast, mastectomy: 1. Intraductal papilloma (A10). 2. Breast with previous treatment effect. B. Left nipple areola margin, excision: Subareolar tissue with lactiferous ducts, no. carcinoma. C. Right breast, mastectomy: 1. Atypica! lobular hyperplasia. 2. Breast with previous treatment effect. D. Right breast, areola margin, excision: Apocrine metaplasia, no carcinoma. pecimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Cervical, Thin Prep Imaged Final Diagnosis Cervical, Thin Prep Imaged NEGATIVE FOR INTRAEPITHELIAL LESION OR MALIGNANCY SPECImEN ADEQUACY: Satisfactory for evaluation. Transformation zone components are present.. Status: Signed Out Accessioned: Specimen Class: Signed Out: Specimen(s) Received: Left Breast, Fine Needle Aspiration. Final Diagnosis Left Breast, Fine Needle Aspiration: Adenocarcinoma (see comment). Status: Signed Out Accessioned Specimen Class: Signed Out: Specimen(s) Received: Vaginal/Cervical/Endocervical, Direct Final Diagnosis Vaginal/Cervical/Endocervical, Direct CELLULAR CHANGES WITHIN NORMAL LIMITS. Paar 5 ^f A
+
+--- Page 6 ---
+Surgical Pathology - Working Draft SPECIMEN ADEQUACY: Satisfactory for evaluation. Endocervical cells present.. Status: Signed Out Accessioned _ Specimen Class: Signed Out: Specimen(s) Received: A) POC Finat Diagnosis.d UTERINE CONTENTS, ABORTION: IMMATURE PLACENTAL VILLI AND DECIDUA, CONSISTENT WITH PRODUCTS OF CONCEPTION. Conversion mD Paee 6 of 6 FND OF RFPORT
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diff --git a/output/text/4bf46435-20eb-4893-8e6c-0476a484cd68.txt b/output/text/4bf46435-20eb-4893-8e6c-0476a484cd68.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1811e1c0bc8c8f1666b40ed7b30f87e8a1e432dc
--- /dev/null
+++ b/output/text/4bf46435-20eb-4893-8e6c-0476a484cd68.txt
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+
+--- Page 1 ---
+SURGICAL PATHOLOGY REPORT Clinical Diagnosis & History: old with sigmoid colon cancer. Specimens Submitted: 1: sp: Colon, terminal ileum, appendix; total colectomy. DIAGNOSTS : Sp: Colon, texminal ileum, appendix; total colectomy: Tumor Type: Adenocarcinoma Histologic Grade: Moderately differentiated. Tumor Location: Sigmoid colon Tumor Size: Length is 3 cm Width is 4 crn Maximal thickness is 0.3 cm Tumor Budding: Focal Increased Tumor : Infiltrating Lymphocytes: Absent Precursor Lesions: Tubular adenomad Deepest Tumor Invasion: Subserosal adipose tissue and/or mesenteric fat. Gross Tumor Perforation: Not identified Lymphovascular Invasion: Identified Large Venous Invasion: Not Identified. Perineural Invasion: Identified Surgical Margina:. Free of tumor  Polyps/Mucosa Dysplasia (away from the carcinoma):. Tubular adenoma; number: 3 Non-Neoplastic Bowel:. Extensive melanosis coli ** Continued on next page
+
+--- Page 2 ---
+Page 2 of 3 Appendix: Unremarkable Lymph Nodes: Number with metastasis: 3 Total number examined: 108 Tumor staging (AJcc 7th Edition): pT3 (Tumor invades through the muscularis propria into pericolorectal tissues) Lymph Node Stage (Acc 7th Edition) : N1b (Metastasis in 2-3 regional lymph nodes). NOTE: THE IMMUNOHISTOCHEMICAL STAINING FOR THE TESTED DNA MISMATCH REPAIR PROTEINS (MLH1, MSH2, MSH6, PMS2) IS RETAINED IN THE TUMOR. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED SREPOR Electzonically Signed Out *** Special Studies: Result Special stain Comment RECUT Gross Description: 1). The specimen is received fresh, labeled "total colectonya" and consists of a segment of terminal ileum, cecum with attached appendix, ascending, transverse, descending and sigmoid colon. The terminal ileum measures 12 cm in length and 3.5 cm in circumference at the proximal resected margin. The remaining colon measures 95.5 in length with a circunference of nine cm at the distal resected margin. The attached appendix measures 8 cm in length. and averages 0.5  cm in diameter. The appendiceal and intestinal serosa is pink tan and smooth..  Focally hemorrhagic lobulated yellow tan adipose tissue spans the length of the specimen measuring up to 2.5 cm in thickness. The specimen is opened to reveal a mass lesion measuring 3 cm in length and 4 cm in width. The mass is located in the sigmoid colon, 85 cm from the proximal margin and 7 cm from the distal margin. Sectioning shows that the tumor invades the muscularis propria and possibly the serosa. The depth of invasion is 0.3 cm grossly. The remaining mucosa shows two sessile polyp.. measuring 0.5 x 0.5 x 0 .3 and 0.3 x 0.2 x 0.2 cm. The attached adipose tissue is submitted for lymph node dissection and all identified lymph nodes are submitted. The colon is extensively sampled with representative sections Submitted for permanent sections and for rps.. Sunmary of sections: PM - proximal margin shave. DM - distal margin shave.
+
+--- Page 3 ---
+3of 3 - polyps A - appendix representative sectiong Summary of Sections: Part 1: SP: Colon, terminal ileum, appendix; total colectomy Block Sect. Site PCa 1 DM 1 1 23 LN 85 1 PM RS 5 * End of Report
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diff --git a/output/text/4c2fd9fc-05a0-4335-944b-3d2a2fa2650e.txt b/output/text/4c2fd9fc-05a0-4335-944b-3d2a2fa2650e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..13dec8f66e2450ee427f2c6797ba17ea2b3654c1
--- /dev/null
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+
+--- Page 1 ---
+JC-0-3 C 50.4 PH Site : Brst,u0Q dw r/19/s cQcF 9rt: Drust,nes C50.9 Diagnosis: 1. Ablated (lefty breast sample with a moderately differentiated invasive ductal carcinoma with an intraductal component (tumor diameter: 5.0 cm. Tumor classification: NOS, G II, pT2N1aL0V0R0 UUID:D1456192-83E7-4FC8-8783-90D615830156 TCGA-A8-A07F-01A-PR Redacted
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diff --git a/output/text/4c536832-0f97-4944-9a0c-13b21153237c.txt b/output/text/4c536832-0f97-4944-9a0c-13b21153237c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..72b16e3fb6b8106a3b836d39b8be04a0acc80687
--- /dev/null
+++ b/output/text/4c536832-0f97-4944-9a0c-13b21153237c.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:4B22FF88-FDD8-4B37-A300-DC84841A6273 TCGA-B9-A5W8-01A-PR Redacted xcD-6-3  reuof 86013 Qell Diagnosis: A: Kidney, right, partial nephrectomy Cb4.9 h 3//sl13 Procedure: Partial nephrectomy Laterality: Right. Histologic tumor type/subtype: Renal cell carcinoma, papillary type Sarcomatoid features: Not identified. Histologic grade (if applicable): Furman grade 3 (of 4) Tumor size (greatest dimension): 1l.8 cm (gross measurement) Tumor focality: Unifocal. Extent of tumor invasion (if present specify if macroscopic or microscopic) : Capsular invasion/perirenal adipose tissue: Not submitted. Gerota' s fascia: Not submitted Renal sinus: Not submitted. Major veins (renal vein or segmental branches, Ivc): Not submitted Ureter: Not submitted. Venous (large vessel): Not submitted. Lymphatic (small vessel): Not identified. Histologic assessment of surgical margins:. Renal parenchymal margin (partial nephrectomy only): Negative, 2mm (A1) Renal capsular margin (partial nephrectomy only): Negative, < 1. mm (A5) Adrenal gland: Not submitted Lymph nodes: Not submitted Pathologic findings in non-neoplastic kidney: Scattered sclerotic glomeruli and arterioles with intimal thickening are present in sections taken from grossly uninvolved kidney. parenchyma adjacent to tumor..
+
+--- Page 2 ---
+AJcc Staging: pT2b pNX This staging information is based on information available at the time of this report, and is subject to change pending clinical review and additional information. Clinical History: -year-old man with a right renal mass. Per , the patient has a 9 cm right renal mass suggestive of possible renal cell carcinoma and most likely brain metastasis. Gross Description: Specimen fixation: formalin. Type of specimen: partial nephrectomy Side of specimen: right. Size and weight of specimen: 745.0 grams, 12.0 x 9.2 x 9.5 cm Orientation: The parenchymal margin is inked black, and the capsule is inked blue.. Presence/absence of adrenal gland: absent Tumor site: per , posterior central right kidney Tumor description: yellow/brown, multinodular and well circumscribed with extensive areas of hemorrhage and necrosis Tumor size: 11.8 x 9.2 x 9.5 cm Presence/absence of multicentricity: absent Confinement/non-confinement to the kidney: grossly confined Extent of invasion: Perirenal adipose tissue: not submitted Gerota' s fascia: not submitted.
+
+--- Page 3 ---
+Renal vein: not submitted Ureter: not submitted. Renal Sinus: not submitted Pelvicaliceal: limited uninvolved kidney for evaluation Adrenal: not submitted. Parenchymal margin: 2 mm Capsule: 1 mm Description of kidney away from tumor: extremely limited, uninvolved kidney available for evaluation (4.7 x 7.5 x 0.1-2.1 cm); appears tan and firm without grossly evident lesions; no urothelium is available for evaluation. Hilar lymph nodes: not submitted. Other significant findings: none. Tissue submitted for special investigations: Tumor is submitted to Tissue Procurement Digital picture: not taken. Block summary:. (Inking: parenchymal margin=black, capsule-blue) Al-A3 - tumor in relation to black inked parenchymal margin A4 - tumor in relation to grossly uninvolved kidney A5-A6 - tumor in relation to blue inked capsule A7-Al2 - additional representative sections of tumor A13 - representative section of grossly uninvolved kidney (nearest tumor 3 mm away) Tissue remains.. w 233
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diff --git a/output/text/4c7ae22e-7457-45c5-b06d-6da8dd087812.txt b/output/text/4c7ae22e-7457-45c5-b06d-6da8dd087812.txt
new file mode 100644
index 0000000000000000000000000000000000000000..555c505c2d0194a46e3768ca5d63c55f3781bbb7
--- /dev/null
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+--- Page 1 ---
+FOR OFFICIAL USE OMLY - PERSOXAL DATA - FRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: FMP/SSN: Specimen #: DOb/Age/Sex: ge: IF Race: wHITE Location: Taken: Physician(s) : Received: Reported: **AMENDED** Jcs-0-3 Carcnome, infi/trutny 1obular, Nos 8520f. SPECIMEN: RIGHT BREAST NEEDLE LOC Sit: breast Nos C50.9 FINAL DIAGNOSIS: BREAST, RIGHT, NEEDLE LOCALIZATION BIOPSY: MULTIFOCAL INFILTRATING LOBULAR CARCINOMA, WELL-TO-MODERATELY DIFFERENTIATED. THE MAXIMAL TUMOR SIZE IS ESTIMATED TO BE 2.8 CM (SEE COMMENT).) THE SURGICAL MARGIN IS POSITIVE FOR TUMOR (SLIDE A5).  MULTIFOCAL LOBULAR CARCINOMA IN SITU. commENr: The tumor is multifocal and present on seven consecutive sections. Based on this finding, the tumor size is estimated to. be 2.8 cm in the largest dimension.. ADDENDUM : Immunostains for hormone receptors are as follows: ESTROGEN RECEPTOR: POSITIVE (7O% OF CELLS, STRONG STAINING)) PROGESTERONE RECEPTOR: POSITIVE (3O% OF CELLS, STRONG STAIING)) HER 2 NEU: 2+ by Herceptest, FIsH pending.. ADDENDUM 2: HER 2 NEU (by FISH): 1.4, NOT AMPLIFIED. ** Report electror -ally Signed Out ** CLINICAL DIAGNOSIS AND HISTORY:S BIRADS IV mammogram. UUID:8169AA00-E396-4A3E-A91C-F67B1F0B8E3E CGA-A2-A0EN-01A-PR Redacted PRE-OPERATIVE DIAGNOSIS: Rule out breast cancer. Page 1 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 Continued on Next Page
+
+--- Page 2 ---
+OR OYFICIAL USB ONLY - FERSOXAL DATA - FRIVACY ACT OP 1974 SURGICAL PATHOLOGY REPORT Patient: GROSS DESCRIPTION: Specimen #: RIGHT BREAST NEEDLE LOC received fresh, labeled with the patient's name, designated "RIGHT BREAST NEEDLE LOCALIZATION" is fibrofatty tissue, 6.3 x 4.4 x 1.5 cm, impaled with a needle localization wire. A radiograph accompanies the specimen. No orientation is provided. The surface is inked black. Sectioning reveals a 1.0 cm indurated mass with poorly defined margins, abutting the inked surgical margin. The fibrous tissue immediately adjacent to the mass is somewhat nodular and focally indruated as well. One section of each mass and grossly normal fibrous tissue is. submitted for CBcp protocol (matching paraffin sections=A5 and A14, respectively). All remaining tissue is serially submitted for paraffin sections in 17 cassettes. The following pairings represent sections taken from the same tissue plane: A5-A6, A7-A8, A9-Ai0, Ai1-A12, Al4-A15, and A16-A17. Page 2 rUK urrsCIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 End of Report.
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diff --git a/output/text/4ca96dec-1594-4541-a065-5ad09f75cc0d.txt b/output/text/4ca96dec-1594-4541-a065-5ad09f75cc0d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..eddc3ca56a6ab8f3d751e6bba4732a6858aca7d2
--- /dev/null
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+
+--- Page 1 ---
+UUID:C026CFCE-1A82-446D-AC78-8CF4788FD9EB TCGA-AR-A254-01A-PR Redacted B2148 Final Diagnosis y/as/ east, left, wide local excision: Infiltrating ductal carcinoma, Nottingham grade III (of III) [tubules 3/3, nuclei 3/3, mitoses 2/3; Nottingham score 8/9], forming a mass (2.7 x 2.3 x 2.2 cm) [AJCC pT2]. Angiolymphatic invasion is absent. The non-neoplastic breast parenchyma shows nonproliferative fibrocystic changes. The skin (separately submitted new anterior margin) is negative. for tumor. All surgical resection margins; after the separately submitted re-excisions of the new anterior, inferior, medial, and. lateral (No. 1 and No. 2); are negative for tumor (minimum tumor free margin, 1.1 cm, lateral margin).. Lymph nodes, left axillary sentinel No. 1, excision: Multiple (2 of 2) matted left axillary sentinel Iymph nodes are positive for metastatic carcinoma. Extranodal extension is present. Blue dye is not identified in either of the two left axillary sentinel lymph. nodes. Lymph nodes, left axillary, dissection: Multiple (7 of 28) left axillary Iymph nodes are positive for metastatic carcinoma. The largest positive lymph node measures 2.1 x 1.4 x 1.4 cm and does not show extranodal extension [AJCC pN2]. Estrogen and progesterone receptor analysis and Her-2/NEU have been ordered on paraffin embedded tissue.. /cs-0-3 Carcinvma mfiPtnat7ny duct Nos 850of3 Sifl: buast, Nos. c50.9 M 4/>s/11
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diff --git a/output/text/4ca9ec8d-b33f-4ef0-9b55-c5de56e20986.txt b/output/text/4ca9ec8d-b33f-4ef0-9b55-c5de56e20986.txt
new file mode 100644
index 0000000000000000000000000000000000000000..56007a27703111cd8e3b4052880024fffdc60c36
--- /dev/null
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+
+--- Page 1 ---
+UUID:A537996A-E747-4906-B488-43181F3C7E17 -A7S9-01A-PR Redacted (Ver i fied) A, Liver. segnentectony : . HEPATOCELLULAR CARCINOMA Tumor number: one Satellite nodule: no Locat ion : : Gross type: expanding nodular Size(cn): 2.3x1.9cm Differentiation: The worst differentiation: Ednondson grade 111 Differentiation: The major ditferentiation: Edmondson grade 1! Histologic type : microtrabecular Cell type : hepatic Tunor necrosis : no Hemor rhage : no Fatty change : no Fibrous capsule : complete Infiltration ot capsule : yes Septum formation : yes Surgical margin inyasion : no(margin of the clearance. 0.5 cm) Serosa invasion: no. Icd-6-3 Portal vein invasion : no arcenome, hepatoeellulor NsS Bile duct invasion : no Hepatic vein invasion : no 8170|3 Hepatic artery Invasion : no Microvessel invasion : no Sie oLwer CQ2.0 Intrahepatic metastasis : no Mult iconteric occurrence : no 1 stage : p11 QsS10[4/13 Non-tumor liver Chronic repatitis : yes Eti logy : HBV Grade, Iobular : minimal Grade. portoper iportal : none Stage(fibrosis) : cirrhosis Cirrhosis : mixed B. GalIbladder. cholecystectony: .Chronic cholecystitis, mild
+
+--- Page 2 ---
+< Iinnunohistochenical and special stain results>. Hepatocyte (block A1): Positive in tumor cells. Cytokeratin 19 (block A1): Negative in tumor cells Cytokeratin 7 (block A5): Positive in bile duct Iron (block A5): Negat ive Cytokeratin 7 (block A4) : Negative A. The specimen received in fornalin consists of a product ot liver segmentectony. measuring 6.3x6.2x2.2cm. The capsule is intact. A vaguely nodular type solid tumor is noted, measuring 2.5x2.Ocm. The cut surface of tumor is grayish honogenous without necrosis. The remaining parenchyna shows cirrhosis.. Representative sections are embedded. (A1 and 2- tumor one plane, A3 and 4- tumor one plane, A5- cirrhotic parenchyma). 8. Tne specinen received in formalin consists of a previously gallbladder. measur ing 5.5cm in length and 2cm in dianeter. The wall measures 0.3cm in maximal thickness. The mucosa is greenish velvety. There Is no. stone or polyp. Repr esentat ive sect ions are enbedded. H&E(6. MT(1). RTC(1). D-PAS(1). Iron(1). Cytokeratin 7(1). Hepatocyte(1). Cytokeratin 19 (1). Cytokeratin 7(1)
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diff --git a/output/text/4ce482d9-0843-4b2c-ac3d-a98605549a18.txt b/output/text/4ce482d9-0843-4b2c-ac3d-a98605549a18.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ff7bbacf8ecc97766a565dc6fdb1f215308abc9b
--- /dev/null
+++ b/output/text/4ce482d9-0843-4b2c-ac3d-a98605549a18.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SPECIMENS: A. MEDIAL UPPER POLE CYST WALL B. RIGHT POSTERIOR UPPER POLE TUMOR SPECIMEN(S): A. MEDIAL UPPER POLE CYST WALL B. RIGHT POSTERIOR UPPER POLE TUMOR GROSS DESCRIPTION: A. MEDIAL UPPER POLE CYST WALL Received in formalin in a container labeled with patient name designated "a. medial upper pole cyst wall" are multiple fragments of beige-tan soft tissue measuring 1.9 x 1.2 x 0.3 cm in aggregate. The entire specimen is submitted in cassette A1.. B. RIGHT POSTERIOR UPPER POLE TUMOR Received fresh labeled with patient name designated "b. right posterior upper pole tumor" is a portion of kidney with attached peri-renal fat weighing 105 gm and measuring overall, 12 x 7.5 x 3.0 cm. A grossly obvious mass protrudes from a ring of normal appearing kidney. The surface of the mass demonstrates an area of disruption measuring 2.0 x 1.5 x 1.0 cm. The lesion measures 2.8 x 2.5 x 2.0 cm.  The normal kidney measures 3.0 x 1.5 x 1.0 cm. The specimen is inked as follows: surface of the Iesion-black, normal kidney margins-blue, peri-renal fat-yellow. Cut section of the lesion shows a well encapsulated red-brown centrally hemorrhagic cut surface. The mass lies directly adjacent to the normal kidney margin at distance of 0.1 cm. Gross photographs are taken. A portion of the specimen is submitted for tissue procurement. Representative sections are submitted as follows: B1-B6: remainder of the lesion and surgical margin B7: lesion and normal kidney B8: portion of normal kidney with attached peri-renal fat  B9: sections of peri-renal fat overlying tumor. DIAGNOSIS: A. KIDNEY, UPPER POLE CYST WALL, EXCISION: - BENIGN RENAL CORTICAL CYST B. KIDNEY, RIGHT POSTERIOR UPPER POLE, PARTIAL NEPHRECTOMY: -PAPILLARY RENAL CELL CARCINOMA (2.8 CM) EXTENDING TO THE INKED ASPECT. SEE COMMENT SYNOPTIC REPORT - KIDNEY (PARTIAL OR RADICAL) Specimens Involved Specimens: B: RIGHT POSTERIOR UPPER POLE TUMOR Specimen Type: Partial nephrectomy Without adrenal gland Laterality: Right Tumor Site: Upper pole Focality: Unifocal Tumor Size (largest tumor if multiple): Greatest dimension: 2.8cm Additional dimensions: 2.5cm x 2cm Macroscopic Extent of Tumor: Tumor limited to kidney WHO CLASSIFICATION Papillary renal cell carcinoma 8260/3 Histologic Grade (Fuhrman Nuclear Grade): G3: Nuclei very irregular, approximately 20 u; nucleoli large and prominent.  Invasion of Vascular/Lymphatic: Absent Perinephric Tissue Invasion:  Absent Margins: Cannot be assessed Adrenal Gland: Not present Regional Lymph Nodes: None sampled Additional Findings: Incidental small cortical glandular proliferation (0.2 cm) best classified as papillary adenoma. See comment..
+
+--- Page 2 ---
+Pathological Staging (pTNM): pT 1a N X M X Comment(s): Representative sections of the main lesion and the incidental adenoma were reviewed by Dr. who concurs with this assessment. Both carcinoma and adenoma share a similar immunophenotype-CK 7  positive, EMA positive, CD 56 negative supporting the above diagnosis. As per the surgeon (Dr.), the lesion was entirely removed with intraoperative visualization of the intact tumor capsule. However, the specimen received in the pathology department exhibited a disrupted capsule at the parenchymal resection side, possibly an ex vivo artifact. Clinical-operative correlation is essential. Close follow-up is indicated. CLINICAL HISTORY:  None given PRE-OPERATIVE DIAGNOSIS: Right kidney mass
\ No newline at end of file
diff --git a/output/text/4d081feb-8e90-4ff0-ade5-16264ac15aed.txt b/output/text/4d081feb-8e90-4ff0-ade5-16264ac15aed.txt
new file mode 100644
index 0000000000000000000000000000000000000000..00d21f558f805a4879b3b5204e910fd35a57b973
--- /dev/null
+++ b/output/text/4d081feb-8e90-4ff0-ade5-16264ac15aed.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Tc P.633 FINAL DIAGNOSIS: Part 1: AxIlLary Sentinel Lymph nOde #1. LEft, siopSy -- Two Lymph nOdes, negative for metastatic CarcinomA. Part 2: AxillAry Sentinel Lymph nOde #2, Left, BiOpsy -- OnE LymPh nODE, NEGATIVE fOR mETASTATIC CARCINOMA. Part 3: breast. Left, total mastectomy -- INVASIVE DUCTAL CARCINQMA. nOTTINghAm GRADE 2 (TUBULAR FORmATION 3, NUCLEAR pOlymOrphism 2, mitotic activity 2; tOtal 7/9). with fOcal mucinous DifferentIatiOn. B. INVASIVE TUMOR MEASURES 2.5 Cm IN LARGEST DImENSION. C.  LYMPHOVASCULAR INVASION IS NOTED (SLIDE 3E). D. ALL SURGICAL MARGINS ARE NEGATIVE; INVASIVE TUMOR IS MORe THAN 1 CM TO THE CLOSEST DEEP MARGIN. nUn-ntOPLASTiC bREASt TISSUE ShOWIng FiBrOcyStIC ChAngE, FLORID DUctAL EPIthELiAL C. HYPERPLASIA, SCLEROSING ADENOSIS. AND mICROCALCIFICATIONS. F. Biopsy site Change (multiple). G.  NIpple. Skin. Negative for CarcinomA. Ics -0 -3 part 4: breast, right, total. mastectomy -. CAwn oma, mfInuHrg olu1l Nos 850of3 A. FIBROCYSTIC CHANGES. DUCTAL EPITHELiAL HYPERPLASIA.S SiHSrst n0s c50.9 3/3 SCLEROSING ADENOSIS. lu C. D. COLUMNAR CELL CHANGES. BIOPSY SITE ChAnGES (2 BIOP$Y SITES).  NIPPLE AND SKIN, UNREMARKABLE. UUID:1E3F22FC-3D82-4911-9C97-8CB87A3D131C F. TCGA-BH-A0DK-01A-PR Redacted Part 5: Final BreaSt SKin margIn, Right, BiOpsy  Skin, Negative for Carcinoma. Part 6: final breast Skin margin, Left, biopsy -- Skin, NegatIvE fOR CarcInomA. 3/
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diff --git a/output/text/4d0c1cda-b682-4422-a66a-68407068fe28.txt b/output/text/4d0c1cda-b682-4422-a66a-68407068fe28.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9dd37b6d5c839f5b8f0205b03684047400a82909
--- /dev/null
+++ b/output/text/4d0c1cda-b682-4422-a66a-68407068fe28.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Page 1 of 2 ( UUID: 275E9EDA-413F-40BE-943C-9521F8CC297A TCGA-G3-AAV3-01A-PR Redacted CONFIDENTIAL SURGICAL PATHOLOGY REPORT Time Collected Time Received Time Reported Time Transmitted Order Number Ordering Provider Status Final Relevant Information Locatlon Copied To Tarseruir c hupeatoexClussrN5 817|3 Report Patient Name: Site.: iliur Ca3. Demographics (for verification purposes) Date of Birth: Q/>s/zc>/y Sex: F SURGICAL PATHOLOGY REPORT **Surgical Pathology Repo Accession Number Collected Date/Time Received Date/Time Pathologist Specimen Description A.  Liver segment 3 at Clinical Information Solid mass in the left lobe of the liver Infectious patient: Yes: Hep C +ve Immunocompromised: No History of neoplasm: No Diagnosis Liver, Segment 3, Local Excision: Hepatocellular carcinoma, moderately differentiated (grade II) Positive for focal venous invasion Resection margins clear Background changes of cirrhosis (see comments in micro) Reported by: Electronically signed by: Verified: Synoptic Report Specimen: Liver PROCEDURE: Partial hepatectomy *Minor hepatectomy (less than 3 segments) TUMOR SIZE: Greatest dimension: 8.5 cm *Additional dimensions: 7.0 x 6.0 cm TUMOR FOCALITY: Solitary (specify location) : subcapsular HISTOLOGIC TYPE: Hepatocellular carcinoma HISTOLOGIC GRADE: GII: Moderately differentiated TUMOR ExTENSION (select all that apply): Tumor confined to liver PRIMARY TUMOR (pT): pT2:  Solitary tumor with vascular invasion or multiple tumors none more than 5 cm REGIONAL LYMPH NODES (pN): Cannot be assessed
+
+--- Page 2 ---
+Page 2 of 2 DISTANT METASTASIS (pM) : pMX: Cannot be assessed MARGINS: Parenchymal margin uninvolved by invasive carcinoma. Distance of invasive carcinoma from closest margin:. 0.6 mm *VENOUS (LARGE VESSEL) INVASION (V): *Absent *ADDITIONAL PATHOLOGIC FINDINGS: *Cirrhosis/fibrosis Gross Description Received is a single specimen contain. The remuisition and specimen container are. labelled with the patient's name. The cassette and identifiers are labelled with the Surgical Number The specimen is received fresh and is subsequently placed into formalin.  The container is designated "Liver segment 3". This consists of a segmental resection of liver tissue, weighing 201 g and measuring 9.5 cm across the surgical resection margin x 7.5 cm perpendicular to the resection margin x 6.0 cm. The shape of the specimen appears to be a protuberant nodule beneath the capsule of the liver. The capsule appears grossly intact. The resection margin is painted blue. Much of the sample is occupied by a well rounded, multinodular tumor that shows areas of hemorrhage and possible necrosis. Some of the smaller lobulated nodules are also discolored green. The tumor measures 8.5 x 7.0 x 6.0 cm. This mass extends close to the capsule with areas of sclerosis on the capsular surface. Between the tumor mass and the resection margin is a zone of parenchyma with a nodular, cirrhotic appearance. The tumor lies 0.6 cm from the margin at its nearest point. There is no gross evidence of vascular invasion. Towards one side there appears to be attached adipose tissue on the capsular surface overlying the tumor. Sections are taken as follows: A1 to 4. tumor with nearest resection margin AS to 8. tumor with capsular surface A9/10. additional sections of tumor Al1/12. liver parenchyma away from tumor mass Microscopic Description Sections show hepatocellular carcinoma with the typical nodular and trabecular growth pattern with broad trabeculae, mild to moderate nuclear pleomorphism, and scattered mitotic activity.  The morphology is compatible with grade II hepatocellular carcinoma. There is one focus with venous invasion at the edge of the tumor nodule, but no distant venous invasion can be seen.  The resection margins are clear by 6 mm on the histology evaluation. The liver capsule shows fibrous thickening overlying the tumor. but there is no clear evidence of extracapsular extension and the adherent adipose tissue is not involved. The adjacent liver shows well developed cirrhosis. There are well preserved portal tracts, but architecture between portal tracts and central venules is disturbed with multiple small nodules. There is a chronic inflammatory infiltrate in the portal tracts and fibrous septae focally aggregating into nodules, but also focally showing spill over and obscuring of the liver cell plates, consistent with mild and focal interface hepatitis.  This is mostly made up of small lymphocytes, but plasma cells can be easily found. There is minimal fatty change in the parenchyma and minimal hemosiderin accumulation. No other abnormal inclusions can be seen. Immunostains for hepatitis B surface and core antigen are negative. The etiology of the underlying cirrhosis is. difficult to ascertain, but the areas with lymphoid aggregates and the past history of documented Hep C would be compatible with this being the main etiology. The presence of plasma cells always the consideration of autoimmune hepatitis, but the morphology is not specific. An additional finding that might correlate with the imageing are areas with bile duct dilation and aggregation in the fibrous septa recapitulating the pattern of Von Meyenbergs complexes, but more comptible with secondary change due to the cirrhosis. Accession Number Encounter Number Patlent Locationd 17/14 Ctiterls  HIPAA Discrepancy rior Malignancy Case is (circle):
\ No newline at end of file
diff --git a/output/text/4d1c73fb-5901-49f7-a6aa-e8a7956339c3.txt b/output/text/4d1c73fb-5901-49f7-a6aa-e8a7956339c3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0e0e8f0f498f24deb657fd8fffe7b47890ff8b7c
--- /dev/null
+++ b/output/text/4d1c73fb-5901-49f7-a6aa-e8a7956339c3.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Path (First Tumor) Tumor Site: Hepatic Flexure Proximal  Date of Cancer Sample Procurement: Histology: Adenocarcinoma Description of other histology:. Grade: Well Differentiated 3 C Yes Mucinous: C No  Yes C Unknown (Focal)  Yes Signet Ring Feature: 6 No C Yes r Unknown (Focal) Histologic Heterogeneity: 6 No C Yes  Unknown Host Response: Crohn's like reaction  None  Yes C Unknown Plasma cell rich stroma C No C Yes C Unknown  Expansile  Expansile Growth Pattern:  Invasive C Unknown and Invasive Inflammatory Bowel Disease r No r Yes 6 Unknown Angiolymphatic Invasion: 6 No C Yes  Unknown Mutator Phenotype: r No  Yes  Unknown Number of Slides 1 C Yes Garland Necrosis present:. 6 No r Yes C Unknown (Focal) TIL Cells/ HPF To Pathologist Comment: 1Cs-0-3 Path Adenocarcionn, mucinous, Nos. 8480/3 CQcF Si#e; Mepete flexure c18.3 hw 5|3| n UUID:499EEF9A-F77A-4F0D-A575-CB52AAB54E98 TCGA-DM-A28K-01A-PR Redacted Criterla Malignany liisto Reviewer lnitial
\ No newline at end of file
diff --git a/output/text/4d2db2a1-f908-4495-9f38-7f42ce9775ee.txt b/output/text/4d2db2a1-f908-4495-9f38-7f42ce9775ee.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0688cb759d6ffe7581bd31f04d1d011bbbb1cdba
--- /dev/null
+++ b/output/text/4d2db2a1-f908-4495-9f38-7f42ce9775ee.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TCGA #: Sample ID #: Diagnosis: Resected colon (sigma) with tumor-free oral and aboral resection margins, with two small tubular adenomas and mild dysplasia (synonymous: mild intraepithelial neoplasia), with a small leiomyoma of the lamina muscularis mucosa, as well as an ulcerated, moderately differentiated adenocarcinoma with infiltration of the perimuscular fatty tissue and with two local Iymph node metastases (G2, pT3, L1, V0, R0 pN1 2/30) 1c0-0- 3 adino cacin omn7 N0s814o|3 Srt: Aignnd. cooN C18.7 hw 3/3fr UUID:6D0B0431-B2C4-41BE-9270-654790FA3170 Redacted
\ No newline at end of file
diff --git a/output/text/4d38013f-a888-4667-8bee-fa73a37452b3.txt b/output/text/4d38013f-a888-4667-8bee-fa73a37452b3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c19cc0f3be9a96713c67c260412c35ae7c003c05
--- /dev/null
+++ b/output/text/4d38013f-a888-4667-8bee-fa73a37452b3.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SPECIMENS: A. RENAL TUMOR B. FAT OVER TUMOR C. LEFT RENAL TUMOR D. LEFT RENAL TUMOR DIAGNOSIS: A. LEFT KIDNEY, TUMOR, CORE BIOPSY: - PAPILLARY RENAL CELL CARCINOMA B. LEFT KIDNEY, FAT OVER TUMOR, EXCISION: - FIBROADIPOSE TISSUE, NO TUMOR SEEN C. LEFT KIDNEY, TUMOR MARGIN, EXCISION: - RENAL PARENCHYMAL TISSUE WITH FOCAL CHRONIC INTERSTITIAL INFLAMMATION, NO TUMOR SEEN D. LEFT KIDNEY, PARTIAL NEPHRECTOMY: - PAPILLARY RENAL CELL CARCINOMA CONFINED TO THE KIDNEY (SEE NOTE) - FUHRMAN'S NUCLEAR GRADE 3 - TUMOR SIZE 6.2 X 4.6 X 3 CM - RENAL PARENCHYMAL MARGIN NEGATIVE FOR TUMOR - ADJACENT RENAL PARENCHYMA WITH ACUTE AND CHRONIC TUBULOINTERSTITIAL NEPHRITIS AND FOCAL GLOMERULOSCLEROSIS - SIMPLE RENAL CORTICAL CYST - SEE TEMPLATE NOTE: The tumor exhibits a papillary growth pattern with morphologic features of types 1 and 2 and. focal cytoplasmic clearing. KIDNEY NEOPLASM TEMPLATE Specimen type: Left partial nephrectomy Tumor site: Not stated Tumor size: 6.2 x 4.6 x 3 cm Focality: Unifocal (correlate with radiology) Extent of tumor: Limited to kidney Histologic Types:  Papillary renal cell carcinoma (see NOTE) Histologic Grade (Fuhrman's): Grade 3 Invasion Vascular/Lymphatic: Absent Perinephric Tissue Invasion: Absent Margins of resection: Parenchymal margin is negative for carcinoma Additional pathologic findings: Renal parenchymal tissue adjacent to tumor with acute and chronic tubulointerstitial nephritis and focal glomerulosclerosis Pathologic Stage: pT1b Nx Mx SPECIMEN(S): A. RENAL TUMOR B. FAT OVER TUMOR C. LEFT RENAL TUMOR D. LEFT RENAL TUMOR CLINICAL HISTORY: Left kidney mass INTRAOPERATIVE CONSULTATION DIAGNOSIS: FSA. Renal tumor: Papillary renal cell carcinoma. By Dr., called to Dr. FSC. Left renal tumor: Benign renal parenchyma, negative for tumor. By Dr. , called to Dr.
+
+--- Page 2 ---
+GROSS DESCRIPTION: A. RENAL TUMOR Received fresh for frozen section are multiple cores of white-tan tissue, each measuring approximately 1.0 x 0.1 x 0.1 cm. The specimen is entirely submitted in cassette FSA1. B. FAT OVER TUMOR Received in formalin is a piece of yellow-pink soft tissue measuring 9.0x 5.7 x 0.5 cm. On sectioning, no masses, lesions or areas of thickening are seen. Representative sections are submitted in cassettes. B1-B5. C. LEFT RENAL TUMOR Received fresh for frozen section are three brown pieces of renal tissue measuring 5.0 x 1.0 x 1.0 cm,. 2.0 x 1.5 x 1.0 cm, and 3.5 x 2.0 x 1.0 cm. Each fragment is oriented with a stitch at the surgical margin. The margins are inked orange, blue and black, respectively. Frozen section is performed on the margins. The specimen is submitted entirely in FSC1-FSC4 (frozen section of margins) and C5-C6. (the remainder of the specimen). D. LEFT RENAL TUMOR Received fresh is a piece of brown-tan kidney tissue weighing 117 gm and measuring 9.0 x 5.0 x 4.0 cm. The surgical margin is inked black and the external capsular surface is inked blue. The specimen is serially sectioned to reveal a 6.2 x 4.6 x 3.0 cm tan-pink cystic friable well-circumscribed mass Iocated 0.1 cm beneath the renal capsule. There are two cysts on the benign appearing parenchyma. measuring 0.4 and 0.7 cm in greatest dimension that contain brown-gold gelatinous material. A photograph is taken and sections of the tumor are procured for the tissue bank. Representative sections are submitted in D1-D3 (one cross section including capsule and surgical margin), D4-D5 (one. cross section including renal pelvis), D6-D9 (tumor), D10 (cyst), D11-D12 (normal appearing renal parenchyma).
\ No newline at end of file
diff --git a/output/text/4d465ea2-f514-4b9f-b25d-9a083c162ba8.txt b/output/text/4d465ea2-f514-4b9f-b25d-9a083c162ba8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d460b6190b2bd2cb74ce2b3c859c1b52accb0d6c
--- /dev/null
+++ b/output/text/4d465ea2-f514-4b9f-b25d-9a083c162ba8.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1c0-0-3 Cartnmu,1obulw,hifil+t^atNg 8520|3 e 50,9 Site Code:breast, Nos Final diagnosis Breast,/left/ wide local excision: Infiltrating mammary carcinoma with predominantly lobular features, solid variant, Nottingham grade III (of III) [tubules 3/3, nuclei 3/3, mitoses 2/3; Nottingham score 8/9], forming a 2.5 x 2.1 x 1.9 cm mass [AJCC pT2]. Focal lobular carcinoma in situ is also present. Angiolymphatic invasion is absent. The non-neoplastic breast parenchyma shows proliferative fibrocystic changes. Biopsy site changes are present. All surgical resection margins are negative for tumor (minimum tumor free margin, 0.4 cm, anterior margin). (See comment.) Lymph nodes, left axillary sentinel, excision: A single (of 3) left axillary sentinel lymph node is positive for isolated tumor cells [AJCC pN0(i+)(sn)], with multiple (5) isolated tumor cells/clusters, the largest measuring 0.05 mm. These isolated tumor cells/clusters are seen on sentinel lymph node #2 and by cytokeratin only staining. Blue dye is identified in left axillary sentinel lymph node No. 1. Blue dye is not identified in left axillary sentinel lymph nodes No. 2 or No. 3. Comment: Immunohistochemical stain (e-cadherin) was performed on the paraffin embedded breast tissue and shows lack of cytoplasmic membrane staining supporting a lobular. immunophenotype. Faxitron done. UUID:D52A6E4B-C80A-4947-96FE-3295E418EC67 TCGA-AR-A1AT-01A-PR Redacted
\ No newline at end of file
diff --git a/output/text/4d5fbaa4-d96d-48d7-bed8-803ee051e2bf.txt b/output/text/4d5fbaa4-d96d-48d7-bed8-803ee051e2bf.txt
new file mode 100644
index 0000000000000000000000000000000000000000..50edf7e16c6f34e73ab6b0f7e45a64f1815a2bd2
--- /dev/null
+++ b/output/text/4d5fbaa4-d96d-48d7-bed8-803ee051e2bf.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:1A100A60-EDE2-4844-A17A-1989520005F6 TCGA-mH-A562-01A-PR  Redacted SURGICAL PATHOLOGY MEDICAL RECORD SURGICAL PATHOLOGY PATHOLOGY REPORT 1es-0-3 LEFT KIDNEY TUMOR pap;liaiy /ensl cll 8a0f3 BRIEF CLINICAL HISTORY: Sin: Kithuy, nes c64.4 PREOPERATIVE DIAGNOSIS: h Renal Mass OPERATIVE FINDINGS: POSTOPERATIVE DIAGNOSIS: Renal Mass PATHOLOGY REPORT GROSS DESCRIPTION: The specimen is received fresh and consists of an 8.2 gm, 3.0 x 2.8 x. 2.3 cm, partial nephrectomy specimen displaying a tan-brown, granular renal resection margin.  The renal capsule is tan-white and smooth. There is minimal attached perinephric fat.  The specimen is inked blue along the renal resection margin and black along the renal capsule. resection margin. The specimen is serially sectioned to reveal a 1.8 x 1.8 x 1.8 cm, tan-white to yellow, granular, well-circumscribed mass. that is 0.2 cm from the renal resection margin and grossly abuts the capsular margin. The specimen is submitted in its entirety sequentially in cassettes 1-5. Please note that a representative portion of tumor is taken for tissue. bank. MICROSCOPIC EXAM DIAGNOSIS: Kidney, left, partial nephrectomy: - PAPILLARY RENAL CELL CARCINOMA PROCEDURE: Partial nephrectomy SPECIMEN LATERALITY: Left TUMOR SIZE: Greatest dimension: 1.8 cm Additional dimensions: 1.8 x 0.8 cm TUMOR FOCALITY: Unifocal MACROSCOPIC EXTENT OF TUMOR: Tumor limited to kidney HISToLOgIcAL TypE: Papillary renal cell carcinoma SARCOMATOID FEATURES: Not identified TUMOR NECROSIS: Not identified
+
+--- Page 2 ---
+HISTOLOGICAL GRADE: Fuhrman Nuclear Grade 3 NOTE: The tumor is predominantly Type 1; however, there are areas of Type 2 histology which show nuclear grade 3 features.. MICROSCOPIC TUMOR EXTENsION: Tumor limited to kidney MARgins: Margins uninvolved by invasive carcinoma LYMPH-VASCULAR INVASION: Not identified. PATHOLOGICAL STAGING: Primary Tumor: pTla Regional Lymph nodes: pNX Distant Metastasis: Not applicable. PATHOLOGICAL FINDINGS IN NONNEOPLASTIC KIDNEY: Insufficient tissue NOTE: concurs with the diagnosis of malignancy in this. case. The Urology Department informed at Staff patholoaist (End of report) Mw nj23|1 SQUALIFE
\ No newline at end of file
diff --git a/output/text/4d7d44e0-b112-4216-9568-3d7b4e99c6fe.txt b/output/text/4d7d44e0-b112-4216-9568-3d7b4e99c6fe.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0bbac2fe0b55e06d26a43dde85f907ad5ebcfb47
--- /dev/null
+++ b/output/text/4d7d44e0-b112-4216-9568-3d7b4e99c6fe.txt
@@ -0,0 +1,21 @@
+
+--- Page 1 ---
+Specimen(s) Received 1. Soft-Tissue:.  It inferior alveolus. 2. Soft Tissue: evel 5B fat 3. Muscle: Deep paraspinal muscles 4. Muscle: Anterior scalene muscle 5. Muscle: Deep scalene margin 6. Muscle: Deep scalene margin 2 tinal resection 7. Vessel: Carotid margin. 8. Soft Tissue: Rt. Level one 9. Oral Cavity: Lt. ventral tongue 10. Oral Cavity: Rt. ventral tongue. 11. Oral Cavity: Rt. posterior floor of mouth, 12. Oral Cavity: Posterior floor of mouth 13. Oral Cavity: Left deep tongue. 14. Oral CavityRt. deep tongue 15. Oral Cavity: Margin mandibulectomy & floor of mouth resection 16. Neck: Level 1 left neck 17. Neck: Level II left neck 18. Neck: Level III left neck 19. Neck: Level IV neck 20. Neck: Level V left neck Diagnosis 1. Left inferior alveolus: - Negative for malignancy. 2. Soft tissue; level VB: - Adipose tissue, negative for malignancy. 3. Deep paraspinal muscles: - Positive for squamous cell carcinoma. 4. Anterior scalene muscle:
+
+--- Page 2 ---
+- Squamous cell carcinoma invading soft tissues and involving the soft tissue margins. 5. Deep scalene margin:. - Negative for malignancy. 6. Deep scalene margin: - Negative for malignancy. 7. Carotid margin: - Negative for malignancy. 8. Right neck; level I: - Submandibular gland with no pathological abnormalities. - Six lymph nodes, negative for malignancy (0/6). 9. Left ventral tongue: - Negative for malignancy. 10. Right ventral tongue: - Negative for malignancy. 11. Right posterior floor of mouth:. - Negative for malignancy. 12. Posterior floor of mouth:. - Negative for malignancy. 13. Left deep tongue: - Negative for malignancy.. 14. Right deep tongue: - Negative for malignancy.. 15. Oral cavity resection; marginal mandibulectomy and floor of mouth:. Squamous cell carcinoma, moderately differentiated. a. The tumour is present in the floor of the mouth. b. Maximum tumour size is 1.2 cm. c. Maximum tumour thickness is 1.2 cm. d. Tumour is close (0.4 cm) to deep margin. e. All other resection margins are free of tumour (> 0.5 cm). f. No perineural invasion identified. g. Bone sections are pending decalcification and will be reported as an addendum.. 16. Left neck; level I: - Metastatic squamous cell carcinoma involving one of seven lymph nodes (1/7).. a. The involved node measures 0.9 cm. b. Extracapsular extension is present. c.Tumour is present very close (< 0.1 cm) to the soft tissue margin.. - Submandibular gland with severe atrophy and chronic inflammation, negative for tumour. 17. Left neck; level II: - Eighteen lymph nodes, negative for malignancy (0/18). 18. Left neck; level III: - Metastatic squamous cell carcinoma involving seven of fifteen lymph nodes (7/15) a. The largest involved node measures 5.0 cm.
+
+--- Page 3 ---
+b. Extensive extracapsular extension present.. C. Tumour is present at the soft tissue margins. 19. Neck; level IV: - Metastatic squamous cell carcinoma involving four of eighteen lymph nodes (4/18) a. The largest involved node measures 3.5 cm. Extensive extracapsular extension present. b. C. Tumour is present at the soft tissue margins. 20. Left neck; level V: - Metastatic squamous cell carcinoma involving two of twelve lymph nodes (2/12) a.  The largest involved node measures 0.5 cm.. b. No extracapsular extension present. Synoptic Data Specimen Type: Resection:Anterior floor of mouth/mandible. Tumor Site: Oral Cavity Histologic Type: Squamous cell carcinoma, conventional Tumor Size: Greatest dimension: 1.2 cm. Tumor thickness: 1.2 cm Histologic Grade: G2: Moderately differentiated. Venous/Lymphatic (Large/Small Vessel) Invasion (V/L): Absent Perineural Invasion: Absent Margins: Margin(s) involved by tumor. Location(s): Soft tissues of neck. Pathologic Staging (pTNM): pTX: Primary tumor of lip or oral cavity cannot be assessed pN2b: Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension for all aerodigestive sites except nasopharynx Number of regional lymph nodes examined: 76 Number of regional lymph nodes involved: 14 Extra-capsular extension of nodal tumor: Present pMX: Distant metastasis cannot be assessed. Electronically verified by: Clinical History mouth cancer Gross Description 1. The specimen is labeled with the patient's name and as "left inferior alveolus". It consists of 3 fragment of polypoid aggregating to 0.9 cm, largest 0.4 cm. The specimen is submitted in toto for frozen section.
+
+--- Page 4 ---
+1A frozen section control 2. The specimen is labeled with the patient's name and "level 5B fat". It consists of portion of fibroadipose tissue measuring 2 x 0.8 x 0.4cm. No nodes identified. The specimen is submitted in toto. 2A level 5B fat 3. The specimen is labeled with the patient's name and as "deep paraspinal muscles". It consists of 2 fragment of tissue measuring in aggregate 1.8 x 0.9 x 0.2 cm. The specimen is submitted in toto for frozen section. 3A  frozen section control 4. The specimen is labeled with the patient's name and as "anterior scalene muscle". It consists of one piece of query fibrous tissue with roughened surface measuring 3.9 x 1.8 x 0.9 cm. On sectioning, the specimen is gray-white and mostly fibrous. The specimen is submitted in toto. 4A-4C scalene muscle 5. The specimen is labeled with the patient's name and as "deep scalene margin". It consists of a fragment of tissue measuring 1.6 x 0.5 x 0.3 cm. The specimen is submitted in toto for frozen section. 5A frozen section control 6. The specimen is labeled with the patient's name and as "deep scalene margin 2 final resection". It consists of a fragment of tissue measuring 1.8 x 1.7 x 0.4 cm. The specimen is submitted in toto for frozen section. 6A frozen section control 7. The specimen is labeled with the patient's name and as "carotid margin". It consists of a fragment of tissue measuring 4 x 0.1 x 0.1 cm. The specimen is submitted in toto for frozen section. 7A frozen section control 8. The specimen is labeled with the patient's name and "right level 1". It consists of portion of fibroadipose tissue measuring 6.5 x 3.7 x 1.8cm. It includes a grossly unremarkable submandibular gland measuring 4.2 x 3.5 x 1.7 cm. Multiple lymph nodes ranging from 0.2 x 0.2 x 0.2 to 1 x 0.4 x 0.4 cm are identified. Representative sections are submitted. 8A submandibular gland 8B multiple nodes 8C multiple nodes 9. The specimen is labeled with the patient's name and as "left ventral tongue". It consists of a fragment of tissue measuring 0.9 x 0.5 x 0.1 cm. The specimen is submitted in toto for frozen section. 9A  frozen section control 10. The specimen is labeled with the patient's name and as "right ventral tongue". It consists of a fragment of tissue measuring 0.5 x 0.2 x 0.1 cm. The specimen is submitted in toto for frozen section. 10A frozen section control
+
+--- Page 5 ---
+11. The specimen is labeled with the patient's name and as "right posterior floor of mouth". It consists of a fragment of tissue measuring 0.5 x 0.3 x 0.2 cm. The specimen is submitted in toto for frozen section.. 11A frozen section control 12. The specimen is labeled with the patient's name and as "posterior floor of mouth". It consists of a fragment of tissue measuring 0.9 x 0.3 x 0.1 cm. The specimen is submitted in toto for frozen section. 12A frozen section control 13. The specimen is labeled with the patient's name and as "left deep tongue". It consists of a fragment of tissue measuring 0.7 x 0.2 x 0.1 cm. The specimen is submitted in toto for frozen section. 13A  frozen section control 14. The specimen is labeled with the patient's name and as "right deep tongue". It consists of a fragment of tissue measuring 0.5 x 0.2 x 0.1 cm. The specimen is submitted in toto for frozen section. 14A  frozen section control 15. The specimen is labeled with the patient's name and as margin mandibulectomy and floor of mouth resection. It consists of an anterior mandible with floor of mouth measuring 3.5 AP x 2.5 SI x 4.5 ML cm. It includes a portion of mandible with 9 teeth. There is a tumor arising in anterior. floor of mouth. The tumor measures 0.7 AP x 1.2 SI x 0.8 ML cm. The tumor is solid and homogeneous. There is no definitive involvement of bone by the tumour. The tumor is located at 0.5 cm from the closest left floor of mouth margin. Remaining margins are as follows: 0.6 cm from the posterior floor mouth margin, 2 cm from the right floor of mouth margin, 1.8 cm from the. inferior muscle resection margin. Representative sections are submitted. 15A left floor of mouth margin 15B right floor of mouth margin 15C posterior floor of mouth margin 15D inferior deep muscle margin 15E-15F tumor 15G left mandible bone margin 15H right mandible bone margin 15l thigh inferior marginal bone margin 15J tumor/mandible bone 16. The specimen is labeled with the patient's name and "level 1 left neck". It consists of portion of fibroadipose tissue measuring 4.6 x 4.6 x 2.6 cm. It includes a submandibular gland measuring 4.2 x 3.8 x 2.2 cm. On sectioning the submandibular gland has a partly fibrous appearance. Multiple lymph nodes ranging from 0.3 x0.3x0.3 to 1.2 x 0.9 x 0.8 cm are identified. Representative sections are submitted. 16A-16B submandibular gland 16C-16D multiple nodes 16E one node bisected 17. The specimen is labeled with the patient's name and "level 2 left neck". It consists of portion of fibroadipose tissue measuring 5.6 x 4.4 x 3.5 cm. Multiple lymph nodes ranging from 0.1 x 0.1 x 0.1 to 1.5 x 1 x 0.7 cm are identified. Representative sections are submitted. 17A-17D multiple nodes 17E one node bisected 17F one node bisected
+
+--- Page 6 ---
+18. The specimen is labeled with the patient's name and "level 3 left neck". It consists of portion of fibroadipose tissue measuring 6.2 x 4.5 x 3.2cm. It is painted with silver nitrate. An exposed partly friable solid tumor on the surface measures 5 x 2 x 2.9 cm. The tumor invades a node and pushes towards the skeletal muscle. The muscle measures 4.5 x 3.8 x 2.6 cm . Multiple lymph. nodes ranging from 0.2 to 1 cm are identified. Representative sections are submitted.. 18A-18C tumor 18D 2 nodes bisected 18E multiple nodes bisected 18F one node bisected 18G-18H tumor 19. The specimen is labeled with the patient's name and "level 4 neck". It consists of portion of fibroadipose tissue measuring 6.5 x 4.5 x 3.5cm. It is painted with silver nitrate. An exposed white. solid partly friable tumor measures 3.5 x 2.5 x 2 cm. The tumor extends towards skeletal muscle. Multiple lymph nodes ranging from 0.2 x 0.2 x 0.2 to 1 x 0.7 x 0.4 cm are identified.. Representative sections are submitted.. 19A-19C tumor 19D-19E multiple nodes 19F one node bisected 19G multiple nodes 19H multiple nodes 19l multiple nodes bisected 20. The specimen is labeled with the patient's name and "level 5 left neck". It consists of portion. of fibroadipose tissue measuring 14 x 4 x 2cm. Multiple lymph nodes ranging from 0.2 x 0.2 x 0.2. to 1.5 x 0.6 x 0.6 cm are identified. Representative sections are submitted.. 20A-20B multiple nodes 20C one node bisected 20D one node bisected Quick Section Diagnosis 1. Left inferior alveolus: Negative for malignancy. Case reported: 3. Deep paraspinal muscles Positive for squamous carcinoma Case reported 5. Deep scalene muscle Negative for malignancy. Case reported
+
+--- Page 7 ---
+6. Deep scale margin, final resection.  Negative for malignancy 7. Carotid margin Negative for malignancy. Case reported: 9. Left ventral tongue Negative for malignancy. 10. Right ventral tongue Negative for malignancy. 11. Right posterior floor of mouth. Negative for malignancy. 12. Left posterior floor of mouth. Negative for malignancy. 13. Left deep tongue Negative for malignancy. 14. Right deep tongue  Negative for malignancy. Case reported Addendum Status: Signed Out Date Reported: Addendum Comment 17. Level II left neck: One lymph node showed a focus of granuloma formation. A GMS and ZN stain have been performed and there is no evidence of infectious organisms identified. Addendum Status: Signed Out Date Reported: Addendum Comment 15. Marginal mandibulectomy/floor of mouth resection (bone sections): - There is no evidence of bone or bone margin involvement by tumour..
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diff --git a/output/text/4dba7c48-29c9-462d-8e53-841870c9cce5.txt b/output/text/4dba7c48-29c9-462d-8e53-841870c9cce5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..db20e77bdb4f07d0dca2ff1fa096e88c7afbc821
--- /dev/null
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+Patient Name Accession #: Med. Rec. #: Date of Procedure: DOB Dale of Receipt: Gender: Date of Report Rel. Physician Account #: Patient Address: Billing Type: Additional Copy to Ref. Source Clinical Diagnosis & History: Metastatic left RCC. Specinens Submitted: 1: SP: Kidney. adrenal gland and hilar lymph nodes, lelt: Radical nephrectomy. 2: SP: Lymph nodes, periaortic, Dissection DIAGNOSIS: SP: Kidney, adrenat gland and hilar lymph nodos, left; Radical nephrectomy: Tumor Type: Renal cell carcinoma, high grade, with lubulopapillary features (SEE NOTE). Fuhrman Nuclear Grade:  Nucleur grade IV/IV Tumor Size: Greatest diameter is 8.5 cm Local Invasion (ior renal cortical lypes): Involves renal hilar fat. Renat Vein Invasion: Angiolymphatic invasion is identified in small vessels and segmental branch of the renal vein. Surgical Margins: Free of tumor Non-Neoplastic Kidney. A PAS stain demonstrates mild arterionephrosclerosis.. Adrenal Gland: Involved by metastatic carcinoma Lymph Nodes:  Number of metastatic nodos:7 Number of nodes exanined:7 which includes nodular lumor deposits suggestive of lymph nodes entirely replaced by tumor. Staging for renal cell carcinoma/oncocytoma:.  pT3b Tunor grossly extends into the renal vein(s) or vena cava below the diaphragm NOTE: Inmunohistochemical stains show positive staining for racemase while CK7, CD10 and CAIX are negative. The differential diagnosis includes a tumor of the distal nephron, collecting duct carcinoma, and type 2 papillary carcinoma; however renal cell Page i of 3
+
+--- Page 2 ---
+a in the selting of hereditary leiomyomatosis is also a consideration. Reviewed a 2. SP: Lymph nodes, poriaortic; Dissection:. L.ymph Node Dissection. Melastalic renal cell carcinoma similar to pad one. Number of lymph nodes examined: 10 Nurnber of lymph nodes with metastatic disease: 4. Sizo of the largest lymph node involved by tumor: 3cm.. Sizeof the largest metastalic focus : 3 cm. Extranodal extension is identified Note: Some of Ihe inmunohistochemistry and ISH tests were developed and Iheir periormance characteristics were determined by the Department of Pathology. They have not been cleared or approved by the US Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. Those tests are used for clinical purposes. They should not be Stigational or for research. This taboratory is cerlified under the Cinical Laboratory Improvement Amendments of as qualified to parform high complexity clinical laboratory testing.. TATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAt EXAMINATON OF THE SLIOES (AND/OR OTHER MATERIAL), AND THAT I KAVE REVIEWEO AND APPROVED THIS REPORT Special Studies:. Result Special Stain Comment PAS CA-1X. RACEMASE CK7 CD10 IMM RECUT NEG CONT H&E(US) RECUT RECUT RECUT RECUT Gross Description: 1) The specimen is received fresh labeled "Left kidney with hilar lymph nodes" and consists of a kidney wilh allached ureler, renal. vessels and perinephric fat weighing 307 g in lolal. The kidney measures 11 x 5 x 4.5 cm. The attached ureler measures 9 cn in length and 0.3 cm in diameter The attached renal vein measures 12 cm in length and 0.4 cm in diameler. The renal vessels and ureler margins are grossly unremarkable. An adrenal gland is identified measuring 5 x 2.3 x 1.4 cm and has a nodular bright yellow cut surface, as well as a 2.3 cm tan solid lesion, grossly identicat to the kidney tumor. The kidney is inked black and bivalved to. reveal a 6.5 x 3.9 x 3.2 cm solid nomogenous fleshy tan somewhat nodular mass located in the upper to mid portion of the kidney, centered at the cortico medullary junction. Sections through the remainder of the kidney reveal a pink brown parenchyma, with a welldetined corlico-medullary junction. The cortex measures 1 cm and the calyces appear normal. Several grossly positive lymph nodes are identified in the hilum, measuring up to 3 2 cm, wilh renal vein present in the mid. hem (the main renal vein is not  involved grossiy). The specimen is photographed. Ropresentative sections are submitted fo (bolh kidney and lymph nodes) and for permanent sections. Summary of sections:. UVM -- ureteral and vessel margins Page ? of 3
+
+--- Page 3 ---
+I- tumor THF-- tumor with hilar fat TSF -- tunor with sinus fat TK -- tumor with adjacent kidney RP -- renal pelvis representative sections K -- represenlative sections kidney AT - adrenal with tumor A--adrenal gland LN -- Iymph nodes (rapresentative sections only if grossly involved) from 0.3 to 3.0 cm in a lesl dimension. All identified lymph nodes are submitled. Tissue from 3 largest. grossly positive lymph nodes is submilted to Summary ot sections: LN - lymph nodes BLN - bisected lymph nodes Summary of Sections: Part 1: SP: Kidney, adrenal gland and hilar lymph nodes, left; Radical nephrectomy Block Sect. Site PCs y** A 1 1 AT 1 1 LN 3 1 RP 1 5 1 5 2 THF 2 2 TK 2 2 TSF 2 1 UVM 3 Part 2:  $P: Lymph nodes, periaortic; Dissection Block Sect. Site PCs BLN 1 1 1 LLN 1 2 LN 2 Page 3 of 3 END OF REPORT
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diff --git a/output/text/4dc0bb5b-2511-40bd-849f-99869fcebe26.txt b/output/text/4dc0bb5b-2511-40bd-849f-99869fcebe26.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a056f82ee1e3c7fbc218a5263884fd52508563df
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+
+--- Page 1 ---
+Page 1 of 6 JUID:BBDD8909-1AE0-4F10-948A-DAA989CF87D2 TcGA-XF-A9SZ-01A-pR Redacted DIAGNOSIS: RADICAL CYSTECTOMY WITH BILATERAL LYMPH NODE DISSECTION, ILEAL CONDUIT DIVERSION AND G-TUBE PLACEMENT: ICD-O -3 RIGHT DISTAL URETER (A) :) INTRAOPERATIVE FROZEN SECTION DIAGNOSIS: 'arsirtme urstlios NoS NEGATIVE 8120|3 FINAL DIAGNOSIS : BENIGN URETER Site Yladde HOS NO UROTHELIAL DYSPLASIA OR CARCINOMA IDENTIFIED Cb7.9 LEFT DISTAL URETER (B): INTRAOPERATIVE FROZEN SECTION DIAGNOSIS: JI3/2k11 4 NEGATIVE FINAL DIAGNOSIS: BENIGN URETER  NO UROTHELIAL DYSPLASIA OR CARCINOMA IDENTIFIED BLADDER / PROSTATE (C) :) INTRAOPERATIVE GROSS DIAGNOSIS: TUMOR IDENTIFIED FINAL DIAGNOSIS: BLADDER: POORLY DIFFERENTIATED UROTHELIAL CARCINOMA, GRADE 4/4, INFILTRATING THROUGH THE MUSCULARIS PROPRIA TO THE PERIVESICAL FAT BUT DOES NOT INVOLVE THE RESECTION MARGIN LYMPHOVASCULAR INVASION IDENTIFIED RIGHT URETER AND BLADDER JUNCTION INVOLVED BY UROTHELIAL CARCINOMA BUT WITH NEGATIVE MARGIN FOCAL UROTHELIAL CARCINOMA IN SITU (FLAT LESION) ALL SURGICAL MARGINS, FREE OF MALIGNANCY CHRONIC CYSTITIS PERIVESICAL LYMPH NODES:S  NO METASTATIC CARCINOMA IDENTIFIED IN SEVEN LYMPH NODES EXAMINED (O/7) PROSTATE:  MULTIFOCAL HIGH GRADE PROSTATIC INTRAEPITHELIAL NEOPLASIA (PIN II-III) NO INVASIVE CARCINOMA IDENTIFIED ACUTE AND CHRONIC PROSTATITIS PROSTATIC ATROPHY CHRONIC PERIARITRITIS RIGHT PARACAVAL LYMPH NODES (D) : METASTATIC CARCINOMA IDENTIFIED IN ONE OUT OF SEVEN LYMPH NODES EXAMINED(1/7 RIGHT COMMON ILIAC LYMPH NODES (E) :  METASTATIC CARCINOMA IDENTIFIED IN FOUR OUT OF 13 LYMPH NODES BXAMINED (4/13), THE LARGEST ONE IS UP TO 1.8 CM WITHOUT EXTRANODAL INVOLVEMENT INFERIOR MESENTERIC ARTERY NODE (F) :)  NO METASTATIC CARCINOMA IDENTIFIED IN THREE LYMPH NODES EXAMINED (0/3) PRESACRAL LYMPH NODES (G):  NO METASTATIC CARCINOMA IDENTIFIED IN TWO LYMPH NODES EXAMINED (O/2) RIGHT EXTERNAL ILIAC LYMPH NODES (H) :
+
+--- Page 2 ---
+Page 2 of 6  NO METASTATIC CARCINOMA IDENTIFIED NODES EXAMINED (0/3) RIGHT NODE OF CLOQUET (I) :  NO METASTATIC CARCINOMA IDENTIFIED IN TWO LYMPH NODES EXAMINED (O/2) RIGHT OBTURATOR / HYPOGASTRIC LYMPH NODES (J) :  NO METASTATIC CARCINOMA IDENTIFIED IN 21 LYMPH NODES EXAMINED (0/21) LEFT PARA AORTIE LYMPH NODES (K):  NO METASTATIC CARCINOMA IDENTIFIED IN SEVEN LYMPH NODES EXAMINED (O/7) LEFT COMMON ILIAC LYMPH NODES (L) :) METASTATIC CARCINOMA IDENTIFIED IN ONE OUT OF EIGHT LYMPH NODES EXAMINED (1/8) LEFT NODE OF CLOQUET (M) : NO METASTATIC CARCINOMA IDENTIFIED IN ONE LYMPH NODE EXAMINED (O/1) LEFT EXTERNAL ILIAC LYMPH NODES (N):) NO METASTATIC CARCINOMA IDENTIFIED IN TWO LYMPH NODES EXAMINED (O/2) LEFT OBTURATOR / HYPOGASTRIC LYMPH NODES (O) : NO METASTATIC CARCINOMA IDENTIFIED IN 14 LYMPH NODES EXAMINED (O/14) RIGHT PRESCIATIC LYMPH NODES (P): NO METASTATIC CARCINOMA IDENTIFIED IN FIVE LYMPH NODES EXAMINED (O/5) LEFT PRESCIATIC LYMPH NODES (Q) :  NO METASTATIC CARCINOMA IDENTIFIED IN 12 LYMPH NODES EXAMINED (0/12) RIGHT PROXIMAL URETER [MARGIN] (R) : BENIGN URETER  NO UROTHELIAL DYSPLASIA OR CARCINOMA IDENTIFIED LEFT PROXIMAL URETER [MARGIN] (S) :) BENIGN URETER NO UROTHELIAL DYSPLASIA OR CARCINOMA IDENTIFIED LYMPH NODE SUMMARY: METASTATIC CARCINOMA IDENTIFIED IN TOTAL OF SIX OUT OF 107 LYMPH NODES.EXAMINED (6/107)) PATHOLOGIC TNM STAGE: T3bN2MX (AJCC-5TH EDITION) SPECIMEN SOURCE: A: "R. distal ureter F/s" B: "Left distal ureter F/s" C: "Bladder/prostate"
+
+--- Page 3 ---
+Page 3 of 6 D: "R. para caval lymph nodes" E: "R. common iliac L. nodes" F: "IMA node" G: "presacral L. nodes" H: "R. external iliac L. nodes". I: "R. node of cloquet" J : "R. obturator/hypogastric L. nodes" K: "e. para aortic L. nodes". L: "L. common iliac L. nodes" M: "L. node of cloquet" N : "L. external iliac L. node" "L. 0: obturator/hypogastric L. nodes" P: "r. presciatic L. node" Q: "L. presciatic L. nodes" R: "R. proximal ureter (margin) " S: "L. proximal ureter (margin)" CLINICAL INFORMATION: Pre-Op Dx:  Bladder cancer Post-Op Dx:  Same GROSS EXAMINATION: A: The specimen is received fresh from the O.R. and labeled "R. distal ureter F/S".  It consists of a portion of ureter measuring 0.2 cm in length by 0.3 cm in diameter.  The specimen is entirely submitted for frozen section in cassette AFs. B The specimen is received fresh from the o.R. and labeled "Left distal ureter F/s". It consists of a portion of ureter with attached fat measuring 0.3 cm in length by o.4 cm in diameter. The specimen is entirely submitted for frozen section in cassette BFs. C:  The specimen is received fresh from the O.R. and labeled "Bladder/prostate". It consists of a cystoprostatectomy specimen measuring 19 x 14.5 x 5 cm. Attached is a peritoneal segment measuring i8.5 x 14.5 x 0.1 cm..  The peritoneum is smooth and glistening.  The prostate measures 5 x 4.5 x 3 cm with attached right seminal. vesicle which measures 2.5 x 1.2 x 0.5 cm and the left seminal vesicle measures 2.1 x 1.2 x 0.5 cm.  Also contiguous is a right distal ureter which measures 6 cm in. length and 0.6 cm in circumference, and the left ureter measures 6.5 cm in length and 0.5 cm in circumference. The bladder measures 8 x 7 x 4 cm. Opening the which occupies the anterior wall and the right lateral wall, that comes within 1 cm from the right ureterovesical junction.  The tumor grossly involves the bladder wall and comes to within o.2 cm from the inked serosal margin. The uninvolved bladder wall measures 0.4 cm in thickness..  The urethra measures 3 cm in length and 0.9 cm in circumference with normal-appearing mucosa.. The outer surface of the prostate is inked black with superimposed red on the right side. Sectioning of the prostate reveals multiple pink-tan soft nodules up to o.4 cm in greatest diameter. Sectioning of the perivesical fat reveals a 2 x 1 cm firm area on the perivesical fat. At the request of the surgeon; an intraoperative gross consultation was performed in order to aid in the care of this patient.  Representative sections are submitted in 39 cassettes. D:  The specimen is received in formalin and labeled "r. para caval lymph nodes".. It consists of a 6 x 4 x 1 cm fatty tissue fragment. Sectioning reveals one lymph node which measures 1.s cm in greatest diameter. Totally embedded in three cassettes. E:  The specimen is received in formalin and labeled "R. common iliac L. nodes". It consists of a 3 x 3 x 2 cm matted lymph nodes with surrounding fat. Totally
+
+--- Page 4 ---
+Page 4 of 6 Gere embedded in five cassettes. F:  The specimen is received in formalin and labeled "ImA node". It consists of a 4 x 3 x 2 cm gray-tan soft tissue fragment. Bisected and totally embedded in one cassette. G: The specimen is .received formalin and labeled -presacral L. nodes". It consists of a 6 x 4 x 0.5 cm fibromembranous fragment with fat. Totally embedded in four cassettes. H: The specimen is received in formalin and labeled "r. external iliac L. nodes".. It consists of a 3 x 2 x 2 cm fibromembranous tissue fragment and fat. Totally. embedded in four cassettes.. I: The.specimen is received in.formalin and labeled "R. node.of cloquet". It consists of"a 0.3 x 0.3 x' 0.2 cm lymph" node.  The lymph node is bisected and. totally embedded in one cassette..  The specimen is received in formalin and labeled nr. obturator/hypogastric L. nodes". 'It consists of a 6 x 5 x 2 cm fibromembranous tissue fragment and fat.. Totally embedded in six cassettes. K The specimen is received in formalin and labeled "L. para aortic L. nodes". It consists of a 2 x 1 x 0.5 cm fatty tissue fragment. Totally embedded in one cassette. L: The specimen is received in formalin and labeled "L. common iliac L. nodes". It consists of three lymph nodes ranging from 0.4 up to 0.5 cm in greatest diameter.  The lymph nodes are totaliy submitted in three cassettes. M: The specimen is received in formalin and labeled "L. node of cloquet". It consists of a 1 x 1 x 0.5 cm fat. The specimen is totally submitted in one. cassette. N: The specimen is received in formalin and labeled "L. external iliac L. node". It consists of a 2 x I x 1 cm fatty tissue fragment. Totally embedded in one cassette. O: The specimen is received in formalin and labeled "L. obturator/hypogastric L. nodes". It consists of a 4 x 3 x 0.5 cm fatty tissue fragment. Sectioning reveals multiple lymph nodes. Totally embedded in four cassettes. P: The specimen is received in formalin and labeled "r. presciatic L. node". It consists of a 1 x 0.5 x 0.3 cm aggregate of fat. Totally embedded in two cassettes. Q: The specimen is received in formalin and labeled "L. presciatic L. nodes". It consists of a 1 x 1 x 0.5 cm aggregate of fat. Totally embedded in two cassettes. R: The specimen is received in formalin and labeled "R. proximal ureter (margin)". It consists of a 1 cm in length and o.2 cm in diameter portion of ureter with stapled end.  The stapled end is inked black. The specimen is trisected and totally submitted in one cassette. S  The specimen is received in formalin and labeled "L. proximal ureter (margin)". It consists of a 1.2 cm in length and o.2 cm in diameter portion of ureter.. The specimen is serially sectioned and totally submitted in one cassette.. SECTIONS : AFS: frozen section, right distal ureter. BEs: frozen section, left distal ureter
+
+--- Page 5 ---
+Page 5 of 6 C1,2: tumor with closest inked serosal margin C3,4 : contiguous section of tumor C5-10: representative sections of tumor C11: random section of posterior bladder wall C12 : random section of trigone C13: section from left lateral wall C14 : bladder dome C15: right ureterovesical junction C16: left ureterovesical junction C17 : right apex C18: left apex. C19: right upper distal prostate C20 : right lower distal prostate C21 : left upper distal prostate C22 : left lower distal prostate C23: right  upper mid prostate C24 : right lower mid prostate C25 : left upper mid prostate c26 : left lower mid prostate C27: right upper proximal prostate C28: right lower proximal prostate C29 : left upper proximal prostate C30 : left lower proximal prostate C31: left upper base prostate. C32: right lower base prostate C33 : left upper base prostate C34 : left lower base prostate C35 : right seminal vesical and vas deferens C36 : left seminal vesical and vas deferens C37-39: firm area in right perivesical fat D1: right paracaval lymph nodes; one lymph node D2,3: remaining tissue E1-5: right common iliac lymph nodes F: inferior mesenteric artery node - all embedded G1-4: left presacral nodes - all embedded H1-4: right external iliac lymph nodes - all embedded. I: right node of Cloquet - all embedded J1-6: right obturator/hypogastric lymph nodes - all embedded. K: left para-aortic lymph nodes - ali embedded L1-3: left common iliac lymph nodes - all embedded M: left node of cloquet  ali embedded N: left external iliac lymph node - all embedded 01-4: left obturator/hypogastric lymph nodes - all embedded. P1,2: right presciatic iymph node -'ail embedded Q1,2: left presciatic lymph nodes - all embedded R: right proximal ureter (margin) - all embedded s: left proximal ureter (margin) - all embedded INTRAOPERATIVE FROZEN CONSULTATION: AFS: Right distal ureter: benign BFS: Left distal ureter:  benign
+
+--- Page 6 ---
+Page 6 of 6 INTRAOPERATIVE GROSS CONSULTATION Bladder (C) : tumor identified MICROSCOPIC EXAMINATION: A-S: See final microscopic-diagnosis.1 114
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diff --git a/output/text/4dc2c8df-8cb3-4e5f-b918-e5c8fa1ad7ef.txt b/output/text/4dc2c8df-8cb3-4e5f-b918-e5c8fa1ad7ef.txt
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index 0000000000000000000000000000000000000000..ed135b0a5d012d5f72a67cf59e6f9403dec746a9
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+
+--- Page 1 ---
+UUID:60ACE338-BEE2-4A49-85F0-1364D245FCA9 Redacted Sample # IEDO3 ilue cromo, inyiltoting, g 8 soe3 Site. FINAL PATHOLOGIC DIAGNOSIS A. Surgical hardware, right breast, removal:. 9J s)e|13 - Implant identified, gross examination only. B. Breast, right, modified radical mastectomy: - Invasive ductal carcinoma, three separate foci measuring 2.8 cm (main lesion) grade II/III, 0.7 cm (satellite #1) grade II/III and 1.1 cm (satellite #2) grade I/III, in greatest dimension, surgical margins negative (see pathologic parameters and comment below) - Ductal carcinoma in situ, intermediate grade, solid and papillary types, surgical margins negative - Uninvolved breast tissue with fibrocystic changess. - Previous biopsy sites present - One of ten axillary lymph nodes involved by metastatic carcinoma (1/10) C. Lymph nodes, right axillary, excision: - Two lymph nodes, negative for carcinoma (0/2) Breast Pathologic Parameters 1. Invasive carcinoma: A. Gross measurement: Three foci - 2.8 cm (main lesion) 0.7 cm (satellite #1) 1.1 cm (satellite #2) B. Composite histologic (modified SBR) grade: II/III (main and. satellite #1) I/III (satellite #2) C. Associated intraductal carcinoma in situ (DCIS): - Within main mass (forming <10% of tumor volume) 2. Surgical margins: - DCIS 5.0 mm from closest margin (posterior) - Invasive carcinoma 5.0 mm from closest margin (posterior) - Additional margins widely free. 3. Blood vessel and lymphatic invasion: Present in breast parenchyma 4. Nipple: Unremarkable. 5. Skin: Uninvolved 6. Skeletal muscle: Absent 7. Axillary lymph nodes: - Current specimen - One of twelve lymph nodes involved by metastatic carcinoma (1/12) - Size of largest metastatic deposit: 1.0 cm - Extranodal extension: Present (1.0 mm; largest focus) - Sentinel node biopsies (.
+
+--- Page 2 ---
+- Two of five sentinel lymph nodes involved by metastatic carcinoma. (2/5) - Size of largest metastatic deposit: 1.0 cm - Extranodal extension: Absent - Total: Three of seventeen lymph nodes involved by metastatic carcinoma (3/17) 8. Special studies (see . : - ER: Strong expression in >90% of invasive tumor nuclei (all three lesions) - PR: Strong expression in >90% of invasive tumor nuclei (all three lesions). - HER2 antigen (FISH): - Main lesion: Non-amplified (ratio: 1.2). - Satellite #1: Non-amplified (ratio: 1.5) - Satellite #2: (IHC): negative (0 - 1+) - Ki67: - Main lesion: 20% - Satellite #1: 20% - Satellite #2: 10% 9. pTNM (AJCC, 7th edition, 201O): pT2(m), N1a, MX Effective I this Checklist utilizes the 7th edition TNM staging system for breast of the American Joint Committee on Cancer (AJCC) and the International Union Against Cancer (UICC). Clinical History: Right Breast Cancer Comment P63 and myosin heavy chain immunohistochemical stains are performed and show a. loss of myoepithelium associated with the invasive component.. Specimens Received: A: Right breast implant B: Right breast with axillary contents C: Additional nodes right axilla Gross Description:
+
+--- Page 3 ---
+The specimens are received in three containers each labeled with the patient's name and medical record number. A. The first container is additionally identified as, 'right breast implant'.. Received in container is a 14 x 14 x 4.5 cm white, round, plastic hardware filled with liquid material. Gross photograph is taken. The specimen is for gross evaluation only. B. The second container is additionally identified as, 'right breast with. axillary contents'. Received fresh and placed in formalin is a 268 gm simple mastectomy specimen. There is a 15 x 6.5 cm capsule pocket implant in posterior inferior aspect of specimen. The specimen isoriented with a double short suture designating the superior aspect and a double long suture designating the lateral aspect. The breast measures 15.5 cm from medial to lateral, 14 cm from superior to inferior, and 2.3 cm from anterior to posterior. On the anterior surface is 13.3 x 5.3 cm yellow-tan ellipse of skin with a 4.8 x 3.8 cm areola and a 1.3 x 1 cm raised nipple. The nipple-areolar complex reveals no evidence of. ulceration or retraction. The specimen is inked as follows: anterior-superior - blue; anterior-inferior - green; posterior - black.. The specimen is serially sectioned from lateral (slice #1) to medial into 13 slices to reveal a 2.8 x 1.8 x 1.5 cm grey-tan, irregular-shaped, rubbery lesion (lesion #1) in slices #6 through #8, which is 0.3 cm from deep margin. There is a 1.1 x 1.0 x 0.3 cm pink-tan, oval nodule (lesion #2) in slice #7, which abuts the capsule pocket and less than 0.5 cm from lesion #1. There is a hemorrhagic area of dense parenchyma measuring 2.8 x 1.5 x 1 cm in slices #9 through #10 which is 1.2 cm from the deep margin. The remainder of the specimen consists of approximately 30 % dense gray-white fibrous breast parenchyma and 70 % lobulated yellow adipose tissue. No additional masses or nodules are grossly identified. Multiple gray-tan, rubbery axillary lymph nodes ranging from 0.3-1.2 cm are dissected. Block summary: B1: nipple B2: skin adjacent to lesion #1, slice 7 B3: Lesion #1, slice 6 B4: Lesion #1, slice 7 B5: Lesion #1, slice 8 B6: Lesion #2 and adjacent lesion #1, slice 7 B7: Lesion #3, slice 9 B8: Lesion #3, slice 10 B9: upper-outer quadrant slice 4 B10: lower-outer quadrant slice 5 B11: upper-inner quadrant slice 8
+
+--- Page 4 ---
+B12: lower-inner quadrant slice 11 B13: 4 lymph nodes B14-B15: 3 lymph nodes B16: One lymph node, trisected B17: One lymph node, bisected B18-B19: One lymph node, serial section B20: 4 lymph nodes C. The third container is additionally identified as, 'additional nodes right axilla'. Received fresh and placed in formalin are 2 yellow-tan, soft tissue fragments measuring 0.5-1.5, which are entirely submitted as C1. MD, PhD lw 4/1o[!3
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diff --git a/output/text/4dd30a14-42eb-4d6b-b762-657da28a3221.txt b/output/text/4dd30a14-42eb-4d6b-b762-657da28a3221.txt
new file mode 100644
index 0000000000000000000000000000000000000000..66d924c5b865b7bfe976aa1df4d032f7e6a9d09b
--- /dev/null
+++ b/output/text/4dd30a14-42eb-4d6b-b762-657da28a3221.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Accession #: Date of Procedure: Date of Receipt: Date of Report: Account #: Billing Type: Additlonal Copy to: TCGA-BP-4981 nosis & History! With right renal mass. Specimens Submitted: 1: SP: KIDNEY AND ADREANL, RIGHT; RADICAL NEPHRECTOMY 2: SP: FALCIFORM LIGAMENT; EXCISION  DIAGNOSIS: SP: KIDNEY AND ADREANL, RIGHT; RADICAL NEPHRECTOMY Tumor Type: Renal call carcinoma - Conventional (clear cell) type. Fuhrman Nuclear Grade:  Nuclear grade lIIV Tumar Size: Greatest diameter is 8.6 cm. Local Invasion (for renal cortical lypes):. Not Identified Renal Vein Invasion:. Identified Surgical Margins: Fraa of tumar Non-Naoplastic Kidney: Unramarkable Adrenal Gland: Not involved Lymph Nodes: Not identified Staging for ranal cell carcinama/oncacytoma:  pT3b Tumor grossly extends into the renal vein(s) or vena cava below the dlaphragm.  SP: FALCIFORM LIGAMENT; EXCISION  Banign fibrocollaganous and adipose tissue. 1ATTEST THAT THE ABOVE OIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERiAL), AND THAT I HAVE  REVIEWED AND APPROVED THIS REPORT. Page 1 of 2
+
+--- Page 2 ---
+Gross Description: 1). The specimen is received fresh labeled "right kidney, right adrenal gland and lymph nodes" and consists of a portion of fibroadipose tissue and a kidney with attached ureter, ranal vessels and parinephric fat weighing 667.5 g in total. The kidney measures 12.6 x 7.5 x 6.0 cm. ' The attached ureter measures 9.5 cm in length and 0.4 cm in diameter. Tha attached renal veln. measures a 0.3 cm in length and 0.7 cm in diameter. The renal vessels and ureter margins are grossly unremarkable. An adrenal  gland is identified and measures 3.3 x 1.7 x 0.7 cm. Tha kidney is inked biack and bivalved to reveal an 8.6 x 7.5 x 6.0 cm well-defined, yellow to light tan, lobulated tumor mass in the superior portion of the kidney. Grossly, the tumor appears to be confined within the renal capsule and compress the renal pelvis without perforating it. However, tumor thrombus is present within the renal vein. Sections through the remainder of the kidney reveal a pink brown parenchyma with a well-defined. cortico-medullary junction. The cortex measures O.5 cm and the calyces appear normal. The specimen is submitted for lymph node dissection. Representative sections are submitted for TPS and for permanent secllons. Gross photos are taken. Summary of sactions: UVM -- ureteral and vessel margins T-- tumor THF-- tumor with hilar fat TSF -- tumor with sinus fat TK -- tumor with adjacent kidney. TRP -- tumor with adjacent renal pelvis, including tumor thrombus In renal vein RP -- an additional renal palvis representative section. K -- representative sections kidney. AD -- adrenal gland PLN - possible lymph nodes 2). The specimen is received in formalin labaled, "Falciform ligament' and consists of a segmant of Indurated fatty tissue  measuring 7.5 x 6.5 x 2.5 cm. The specimen is serially sectioned to reveal a cylindrical white-tan fibrotic tissue measuring 2.5 cm in. length by 0.7 cm in maximum diameter. The specimen is representatively sampled.. Summary of sections: U-undesignated Summary of Sections: Part 1: Sp: KiDney AND ADReanl, RIGht; RADical NEphrECtOMy Block Sect. Site PCs 1 AD 1 2 K 2 PLN 2 RP 1 8 T 8 1 THF 1 2 TK 2 1 TRP 1 1 TSF 1 1 UVM 1 Part 2: SP: FALCIFORM LIGAMENT; EXCISION Block Sect. Site PCs 3 u 5 Page 2 of 2 END OF REPORT
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diff --git a/output/text/4dde22cd-bcd4-46ce-8a53-8b8216a43c71.txt b/output/text/4dde22cd-bcd4-46ce-8a53-8b8216a43c71.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5ff548ca8e21c9e0c093226e0f69921e35890181
--- /dev/null
+++ b/output/text/4dde22cd-bcd4-46ce-8a53-8b8216a43c71.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+BD-9E44-FF0B07697943 TCGA-EW-A6SC-01A-PR Redacted Surgical Pathology Report Name: xxx Case #: x DOb: Collected: Gender: F Received: x MrN: x Reported: x Location: xx Physician: xxx Pathologic Interpretation:. IcD-o-3 NOE A. LEFT BREAST SENTINEL NODE 1 Corcinoma, Selulsr uiflbatiy One lymph node, negative for carcinoma (0/1) 0 8520f3 Immunohistochemistry for keratin is pending B. LEFT BREAST SENTINEL NODE 2 One lymph node, negative for carcinoma (0/1). Des.4 Immunohistochemistry for keratin is pending. YJ 7/24/13 C. LEFT BREASt LUMPECTOMY: INVASIVE LOBULAR CARCINOMA, moderately differentiated, Nottingham grade 2 (3+2+1=6), 2.1 cm in greatest dimension. Immunohistochemistry performed on previous core needle biopsy demonstrated the following staining pattern in the lesional cells:. ER: POSITIVE (> 50%) PR: POSITIVE (10-50%) HER2:  NEGATIVE (0) E-Cadherin:  NEGATIVE (0) Resection margins are negative for carcinoma. Prior biopsy site changes present. Atypical ductal hyperplasia. See Surgical Pathology Cancer Case Summary. Surgical Pathology Cancer Case Summary Procedure Excision without wire-guided localization Lymph Node Sampling Sentinel lymph node(s) Specimen Laterality
+
+--- Page 2 ---
+Left Tumor Site: Invasive Carcinoma Position: 1 o'clock Histologic Type of Invasive Carcinoma Invasive lobular carcinoma Tumor Size: Size of Largest Invasive Carcinoma Greatest dimension of largest focus of invasion >1 mm: 21 mm Histologic Grade: Nottingham Histologic Score Glandular (Acinar)/Tubular Differentiation  Score 3: <10% of tumor area forming glandular/tubular structures Nuclear Pleomorphism  Score 2: Cells larger than normal with open vesicular nuciei, visible nucleoli, and moderate variability in both size and shape Mitotic Rate Score 1 (3 mitoses per mm) Overall Grade Grade 2: scores of 6 or 7 Tumor Focality (required only if more than 1 focus of invasive carcinoma is present).  Single focus of invasive carcinoma Ductal Carcinoma In Situ (DCIS) (select all that apply) No DCIS is present Lobular Carcinoma In Situ (LCIS) Not identified  Margins Invasive Carcinoma  Margins uninvolved by invasive carcinoma Distance from closest margin: 2.5 mm Specify margin: Anterior Lymph Nodes (required only if lymph nodes are present in the specimen) Number of sentinel lymph nodes examined: 2 Total number of lymph nodes examined (sentinel and nonsentinel): 2. Number of lymph nodes with macrometastases (>2 mm): 0  Number of lymph nodes with micrometastases (>0.2 mm to 2 mm and/or >200 cells): 0 Method of Evaluation of Sentinel Lymph Nodes (select all that apply) Hematoxylin and eosin (H&E), 1 level H&E, multiple levels  Immunohistochemistry to follow Treatment Effect: Response to Presurgical (Neoadjuvant) Therapye In the Breast No known presurgical therapy In the Lymph Nodes. No known presurgical therapy Lymph-Vascular Invasion Not identified Dermal Lymph-Vascular Invasion  No skin present  Pathologic Staging (based on information available to the pathologist) (pTNM) Primary Tumor (Invasive Carcinoma) (pT) pT2: Tumor >20 mm but 50 mm in greatest dimension. Regional Lymph Nodes (pN) Modifier (required only if applicable) (sn): Only sentinel node(s) evaluated pNO:  No regional lymph node metastasis identified histologically. Distant Metastasis (pM) Not applicable Ancillary Studies (required only if available at time of report completion) (select all that apply). Performed on another specimen Specify specimen (accession number): --. Estrogen Receptor (ER)
+
+--- Page 3 ---
+Results and interpretation: Positive Immunoreactive tumor cells present ( >50%) Progesterone Receptor (PgR) Results and interpretation:. Positive Immunoreactive tumor cells present (10-50%) HER2 Immunoperoxidase Studies Results: Negative (Score 0) Microcalcifications (select all that apply) Present in invasive carcinoma AJCC Classification (7" edition): pT2, (sn)pN0, pMn/a Final AJCC classification will be issued after the keratin immunostain.. xx, xx, ***Electronically Signed Out By*** Procedures/Addenda Addendum Date Ordered: Status: Date Complete: Date Reported: Addendum Diagnosis A. Immunohistochemistry for keratin is negative. B. Immunohistochemistry for keratin is negative. Final AJCC pT2 sn N0 (i-) Mn/a xx Intraoperative Consultation A. Sentinel node 1, FS: No malignancy seen. However, final diagnosis pending Immunohistochemical stains B. Sentinel node 2, FS: No malignancy seen. However, final diagnosis pending Immunohistochemical. stains Clinical History: Lobular carcinoma, ER+, RR+, HER (-) Operation Performed. Left lumpectomy with sentinel node biopsy and possible axillary dissection. Pre Operative Diagnosis: None Provided Specimen(s) Received/Processing Information:e Codes:
+
+--- Page 4 ---
+A: Left breast Sentinel node 1 Frozen section x 1, FS Perm x 1, Touch  Prep Histology x 1, Cytokeratin Cocktail (KER) x 1 A: B: B: Left breast Sentinel node 2 Frozen section x 1, FS Perm x 1, Touch Prep Histology x 1, Cytokeratin Cocktail (KER) x 1 C: Left breast Lumpectomy 1 SuperiOr 2 LAteral 3 Deep h&e, initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial. x 1 Gross Description:  Received fresh labeled "Sentinel lymph node count 1.  " containing 1.3 x 1.0 x 1.0 cm pale yellow soft A. Iymph node. Bisected and submitted in toto in one cassette for frozen section. B. Received fresh labeled "Sentinel node 2 count  " containing 1.3 x 1.0 x 1.0 cm pale yellow, soft lymph node. It is bisected and submitted in toto in one cassette for frozen section.. C.  Received in formalin labeled "Left breast lumpectomy, 1 superior, 2 lateral 3 deep" is a lumpectomy specimen of the breast weighing 180 grams. It is oriented with sutures by the surgeon. It measures 7.5 cm in superior to inferior, 7.0 cm medial to lateral surface, 3.5 cm anterior to the posterior surface. The specimen is inked as follows: Blue superior, green inferior, red medial, orange lateral, black posterior,. yellow anterior. Upon sectioning, there is a 2.0 x 1.6 x 1.2 cm tan-white, firm gritty mass with stellate borders. It is approximately round to oval in shape. The mass contains a metallic clip measuring 3 mm. The mass is closest to the anterior margin which is 0.7 cm away. It is 3.0 cm away from the posterior margin, 2.0 cm from the superior margin, 2.6 cm from the inferior margin, 4.0 cm from the medial margin and 2.5 cm from the lateral margin. The rest of the breast parenchyma is yellow and soft with fat to stroma ratio 90's to 30. A piece of tumor measuring approximately1.0 x 1.0 cm is submitted to the tissue bank. Sections are submitted as follows:. Cassettes #1-6  Mass in toto (cassette 1 mass with clip) Cassette #7 Anterior margin. Cassette #8 Posterior margin  Medial margin Cassette #9 Cassette #10 Lateral margin Cassette #11 Superior margin Cassette #12 Inferior margin Cassette #13 Stroma
\ No newline at end of file
diff --git a/output/text/4e82ddb6-6231-414a-b6d6-09aab47880dc.txt b/output/text/4e82ddb6-6231-414a-b6d6-09aab47880dc.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b57ec01a000cf7756d06ea329492b40f3e2e2d37
--- /dev/null
+++ b/output/text/4e82ddb6-6231-414a-b6d6-09aab47880dc.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Patient history: Not provided. LMP: Not provided. PRE-OP DIAGNOSIS: Right breast cancer. POST-OP DIAGNOSIS: Same. PROCEDURE: Right breast segmental mastectomy, right axillary sentinel node biopsy. MICROSCOPIC: Microscopic examination substantiates the above diagnosis.. Antibody/Antigen Result AE1/AE3 (1B) negative Utilizing formalin-fixed (8-96 hour range), paraffin embedded tissue, immunohistology is performed with the following selected antibodies and designated antibody clone(s). directed against the following antigenic target(s), with adequate positive and negative internal and external controls. ANTIBODY CLONE TARGET ANTIGEN AE1/AE3 VENDOR AE1/AE3 carcinomas The tollowing statement applies to all immunohistochemlstry, insltu hybridization (ISH & FisH), molecular anatomic pathology, and immunofluorescence testing: The testing was developed and its performance characterlstics datermined by the ! required by the CtiA '88 regulations. The testing has not been cleared or approved tor the speclfic use by the U.s. Food and Drug Administratlon, but the FDA has determined such approva! Is not necessary tor clinical uso. aa This laboratory is certitied under the Cinical Laboratory Improvement Amendments ot 1988 (*CLiA") as qualitied to perform high- complexity clinical testing. Pursuant to the requirements of CLiA, AsR's used In this laboratory have been established and verified for accuracy and precision. Additional Intormation about this type of test is available upon request. CASE SyNOPSIS: SyNOPTiC - PRImARy iNVASIVE CARCinOMA OF BREAST LATERALITy: ProceDUre: Right LOcatiOn: Segnental Not specified Size of tumor: Maximum dimension invasive component: 1.4 cm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: No TUMOR TYPE (invasive component): UUID:87E28DAE-5012-4A16-BE27-A9F0F3F30F5B Metaplastic carcinoma.) TCGA-BH-A0WA-01A-PR Redacted NOTTINGHAM SCORE: Nuclear grade: 3 Tubule formation: 3 Mitotic activity score: 3 Total Nottingham score: 9 Nottingham grade (1. 2, 3): 3 ANGIOLYMPHATIC INVASION: No DERMAL LYMPHATIC INVASION: No CALCIFICATION: Yes, benign zones Tumor type, in situ: Cribritorm Solid DCiS admixed and outside of invasive carcinoma component Percent of tumor occupied by in situ component: 5 % SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No Distance of invasive tumor to closest margin: 2.0 mm SURG MARGINS INVOLVED BY IN SITU COMPONENT:E No Distance of in situ disease to closest margin: 4.0 mm Lymph nOdes PosiTive: LymPH NODES EXAMInED: 0 3 /c0-0-3 METHOD(S) OF LyMPH NODE EXAMINATION: H/E stain, Keratin stain SENTINEL NODE METASTASIS: SKIN INVOLVED (ULCERATION): No Sife. huast, NOs No C50.9 t stage, pathologic: N stage, pathologic: pT1c m stage, pathologic: pN0(i-) Estrogen receptors: pMX  negative ProgesteRone ReceptORs: HER2/NEU: negative PAA zero or 1+ tof s/11
+
+--- Page 2 ---
+PATIeNT HISTORY: Not provided. LMP: Not provided.* PRE-OP DIAGNOSIS: Right breast cancer. POST-OP DIAGNOSIS: Same. PROCEDURE: Right breast segmental mastectomy, right axillary sentinel node biopsy. FINAL DIAGNOSIS: PART 1: LYMPH NODES, RIGHT AXILLARY, SENTINEL #1, BIOPSY -- THREE (3) LyMPH NODES NEGATIVE FOR METASTATIC CARCINOMA (0/3). part 2: breast, right, segmental mastectomy -- A.  INFiLTRATING DUCTal CArCinOMA, METaPLASTIC TYPE. B.  NEOPLASM MEASURES 1.4 CM ON SLIDE C  NOTTINgHAM SCORE: 9/9, GRADE 3. D.  MARGINS OF RESECTION FREE OF NEOPLASM, CLOSEST POSTERIOR AT O.2 CM. E.  NO LYMPHOVASCULAR INVASION IDENTIFIED. ER NEGATIVE, PR NEGATIVE, HER-2/neu NEGATIVE (SCORE: 1+) PER PREVIOUS REPORT. G. PATHOLOGIC STAGE: pT1c pN0 pMX. H. DUCTAL CARCINOMA IN SITU, SOLID AND CRIBRIFORM TYPES, NUCLEAR GRADE 3 WITH COMEDO NECROSIS. DUCTAL CARCINOMA IN SITU IS ADMIXED AND ADJACENT TO INVASIVE COMPONENT. J.  MARGINS OF RESECTION FREE OF DUCTAL CARCINOMA IN SITU, CLOSEST POSTERIOR AT 0.4 CM. K. UNREMARKABLE SKIN MONCKEBERG'S CALCIFIC MEDIAL SCLEROSIS OF ARTERY. COMMENT: One of the lymph nodes is confirmed negative by Immunohistochemical staining (1B). The positive basal-tike.  Immunohlstochemical markers performed on the previous blopsy combined with the presence of matrix production and squamous differentiation in the current specimen support metaplastlc subtype of Infiltrating ductal carcinoma..
\ No newline at end of file
diff --git a/output/text/4e9fbc01-af94-4bf7-99b5-750655addfb5.txt b/output/text/4e9fbc01-af94-4bf7-99b5-750655addfb5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..520f6db710c09d5cb84805da16d70ddee018e33f
--- /dev/null
+++ b/output/text/4e9fbc01-af94-4bf7-99b5-750655addfb5.txt
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+
+--- Page 1 ---
+PATIENT HISTORY: Colon cancer, COPD, thoraco of abdominal aneurysm.. PRE OP DIAGNO$IS: Cecal mass. PoSt OP biagnOSIS: Same. PROCEDURE: Right hemicolectomy. ADDENDA: Addendum  In situ hybridization studies performed on the moderately differentiated adenocarcinoma of the right colon show a ratlo. of Her-2/neu gene to the centromere of chromosome 17 of 1.66. This indicates low ievel amplification of the Her-2/neu oncogene in the targeted region FINAL DIAGNOSIS: PART 1: COLON, RIGHT, HEMICOLECTOMY Moderately differentiated adenocarcinomA. A B. Tumor size 6.0 x 6.0 x 5.0 CM. Tumor invading through the muscularis propria to the subseRosal aDi ISSDE C. D. SURGICAL, MARGINS FREE OF TUMOR. E.  NO eVIdeNCE OF ANGIOLymPHATIC OR PeRinEURAL InVASION. F. Twenty-four (24) lymph nodes free of tumor. G. TUMOR STAGE: pT3N0MX Part 2: GaLLBLadDer, Cholecystectomy - A. Cholelitmiasis wIth Chronic cholecystitis. B. NO EVIDENCE OF MALIGNANCY. COMMENT: Part 1: Multiple sections of the right colon tumor mass show a moderatoly differontiated adenocarcinoma consisting of well-formed malignant glands. In some area, the tumor cells contaln abundant mucin vacuoles with a signet-ring. appearance. However, individual infiltrating signet-ring cells are not seen. In other areas, the tumor cels form nests or trabcculae with irregular to angular nuclei and visible nucleoli. Although the lattor component raises the possibility of neuroendocrine differentiation, immunostains for the neuroendocrine markers synaptophysin and chromogranin are both negative. Theretore, this tumor is best characterized as moderately differentiated adenocarcinoma.. Ras reviewed this case and agreed with the diagnosis. SYNOPTIC : PRIMARY COLON AND RECTAL TUMORS A. Location: 2 1. Ileocecal Region 4. Descending Colon 2. Ascending Colon Sigmoid Colon 3.Transverse Colon 6. Rectum Procedure. 1 Segrnental Colectomy 3. Other Total Colectomy C. Size of Turnor (maximum dimension) 6.0 x 6.0 x 5Q.cm D). Type: 1 1. Acenocarcinoma, NOs 9. Squamous Cell Carcinomg 2. Adenocarcinoma arising in a background 10. Undifferentiated Carcinoma  Of an adenoma. 11. Sarcoma 3. Adenocarcinoma arising in a background 12. Smooth Muscle Tumor  of intlammatory bowel disease 13. Gastrointestinal strornal tumor 4 Adenosquamous carcinoma 14. Lymphoma 5 Carcinoid Tumor (Neuroendocrine Tumor) 15. Other 6. Mucinous Adenocarcinoma 7. Signet ring cell type Adenocarcinoma 3.Neuroendocrine Carcinoma E. Grade: 2 1. Wen differentiated 2.Moderately differentiated 3.Poorly differenliated Extent of Infiltration.  1. Limited to the mucosa 4. Intiltraling through muscularis propna into serosal 2. Into submucosa adipose tissue 3. Involving muscularis propria 5. Involving adjacent organs/ peivic wall G. Angiotymphatic Invasion: 2 Yes 2.No H Surgical Margins Involved. 2 Yes 2.No Regional Lymph Node invoivement: 2 "Yes 2.Na If regional ymph nodes involved, Number positive/number examined: #/# Extracapsular spread : 2 Yes 2.No. Associated conditions: N/A Uicerative colitis. Crohns Disease History/ presence of adenomatous polyps. 4. Multiple polyposis syndromes. Diverticulosis. M. tnm Stage. t3 n@mx N. Dukes' Stage:2 1. A (limited to mucosa and muscularis) 2. 3.(hrough muscularis into subserosa). 0. Astler - Coller Stage: 3 1. A (mucosa but not into mnuscularis propria) 2. B1 (muscularis propria but not through, LN negative) 3. 82 (through muscularis propria into subserosal fbroadipose tissue, LN negative) 4. C1 (timited to musculans propria but not through serosa, LN positive). 5. C2 (invades serosal adipose tissue, LN positive)
\ No newline at end of file
diff --git a/output/text/4ebf651c-c221-4fe1-8264-8bc97d59f78f.txt b/output/text/4ebf651c-c221-4fe1-8264-8bc97d59f78f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ec24faa4e8030a56d6357be3cc90586e915a795d
--- /dev/null
+++ b/output/text/4ebf651c-c221-4fe1-8264-8bc97d59f78f.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+p.32/33 tNAL DIAGNOSIS: PARt 1: Lymph nODE, RIght AXIlLARy, SENTInel NOde #1, BIOpSy - - ONE LYMPH NODE, POSITIVE FOR CARCINOMA (1/1) (SEE COMMENT). Part 2: breast. Right,modified radical mastectomy - A.Invasive LoBular Carcinoma. pleomorphic type with focal Signet cells. B. nOtTINGhAm gRADe II (TuBULE fORmATiOn- 3; nucLEAR PLEOmORphISm-3; mITOtIC AcTiviTy - 1: TOTal SCORe 7(9). C. The InVASive CARcInOmAS ARe LOcATeD AT the 12 O'CLOCk AnD 6 O'CLOCK POSITIOnS. THE INVASIVE TUMOR MEASURES 2.5 CM IN GREATEST DIMENSION (TUMOR IN 12 O'CLOCK, GROSS MEASUREMENT). D. LOBULAR CARCInOmA IN SiTU (LCIS). NUCLEAR GRADE 2-3, ADmIXED WiTH INVASiVE CARCinOMA. E. RESECTION MARGINS ARE NEGATIVE fOR In SiTU AND INVAsSIVE CARCINOMA. F. LymphovascuLar Invasion is .not noted. G. nIpple and skin are negative for tumor. H. TWO OF 11 Lymph nODeS (Zi11) ARE POsITiVE FOR CARcINOMA. 1.  MICROCALCIFICATIONS ARE ASSOCIATED WITH THE INVASIVE AND iN SITU CARCINOMA.  FIBROCYSTIC CHANGES AND SCLEROSING ADENOSIS. K. THe INVASiVE TUMOR CELLS ARE POSITIVE fOR ESTROGEN AND PROGESTERONE RECEPTORS AND NegaTive fOr her2/neU, As PEr preVioUs PatholOgy REpORt :. Case synopsis: SYNOPTiC - PRIMARY iNVASIVE CARCINOMA OF 8REASTE LATerALITy: Right PROCEDURE: Modified radical mastectomy LOCATION: Central subareolar Lower outer quadrant SIZE OF TUmOR: Maximum dirnension invasive component: 2.5 cm MULTICENTRICITYAMULTIFOCALITY OF INVASIVE FOCI:E Yes Tumor aggregate size: Sum of the sizes ol multiple invasive tumors: 4.5 cm TUMOR TYPE (invasive component): Infiltrating lobular carcinoma 1cs-0-3 histologic type: Plcomorphic, Slgnel ring  NOtTinGham ScOre: Nuclear grade: 3 Cawciiomn, nifi1mutmy 1obnley, nos 8520J Tubule formation: 3 Situr bunot, Nos Mitotic activity score: 1 c50.9 3/3/11 h Totat Nottingham score: 7 Nottingham grade (1. 2. 3): 2 AnGiOLymphATIC inVASIOn: No DERMAL LYMPHATIC INVASION: No CALCIFICATION: Yes. malignant zones Tumor type, in situ: I.CIS, Percent of tumor occupied by in situ component: 30 % SurgiCal mARgiNs invOLVeD sy inVAsIve COmpONenT: No SURG MARGINS INVOLVED BY IN SITU COMPONENT:E No PAGET'S DISEASE OF NIPPLE: No Lymph nodes positive: 3 LYMPH NODES EXAMINED: 12 methOD(S) Of LymPh nODE EXAminAtION: SENTINEL NODE METASTASIS: Yes SIZE OF NODAL METASTASES: Diameter ot largest lymph node metastasis: 15 mm LYMPH nODE METASTASIS(-ES) WITH EXTRACAPSULAR EXTENSION: No SKIN INVOLVED (ULCERATION): No Critria NON-NEOPLASTIC BREAST TISSUE: FCD rimary Tumor Site Di t Stage, pathologic: N stage, pathologic: p72 pN13 Dual/Synch M stage, pathologie: Case is (circle ESTROgEn RECePTORS: pMX PROGESTERONE RECEPTORS: positive positive HER2/NEU: zero or 1+ UUID:8FDACA3D-C172-4198-9888-8F9E5A5FF0D6 TCGA-BH-A0E9-01A-PR Redacted
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diff --git a/output/text/4ef5d4c7-c822-4fcd-a014-a3bd771b39ac.txt b/output/text/4ef5d4c7-c822-4fcd-a014-a3bd771b39ac.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a45446b0c698b6f3f3bda69c9974b53cef56976d
--- /dev/null
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+
+--- Page 1 ---
+Sample Number Sample Type TUMOUR  Diagnosis  papillary renal carcinoma  Year of Sample Collection Age at Sample Collection (yrs)  Days to Procedure Date  Days to Diagnosis Type of Procedure. RESECT  Site of Tissue/Primary (Histology).  left kidney Tumour Size (cm) 4 Histology  papillary renal carcinoma  Grade/Differentiation III  Pathological T T1a  Pathological N NX Clinical M  MO Histology Comments  Fuhrman nuclear grade 3/4 Sample Number Sample Type BUFFY  Year of Sample Collection  Age at Sample Collection (yrs).  Days to Procedure Date  Days to Diagnosis UUID:102D45C0-82F2-451E-B7DA-AA30F31FC98C TCGA-HE-A5NI-01A-PR Redacted IgD o 3 8260/3 5i+e Kidney NsS C64.9 SJq/u113 h yf7fi3
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diff --git a/output/text/4f04049d-1bea-4d6d-8480-908ab905f7d1.txt b/output/text/4f04049d-1bea-4d6d-8480-908ab905f7d1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..204c078dfdafb2577275e59cadee8b821cf0ea8f
--- /dev/null
+++ b/output/text/4f04049d-1bea-4d6d-8480-908ab905f7d1.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Jcs-0-3 Caciiomu. htfiltnatny,ductl,Nos 850sf3 Site: brsf.Nos C5v.9 3[11" page 1 / 1  Department of Cancer Pathology copy No. Date: Examination: Histopathological examination Internal invoice No. Cost of diagnostic procedure Examination No.: ' Patient: xXX PESEL: XXX Age: Gender: F  Material: Multiple organ resection -- right breast and axillary tissue  UUID:49C79E09-2F69-4089-BFB1-53197DA09A46 Unit in charge: TCGA-D8-A13H-01A-PR Redacted Physician in charge: Material collected on: . Material received on: Expected time of examination: up to 8 working days Clinical diagnosis: Cancer of the right breast. Examination performed on: Results of.immunohistochemical examination: Estrogen receptors found in over 75% of neoplastic cell nuclei. Progesterone receptors found in over 75% of neoplastic cell nuclei. HER2 protein stained with HercepTestTM by DAKO.  Negative reaction in invasive cancerous cells ( Score = 1+ ) Compliance validated by: Examination performed on Macroscopic description: Right breast sized 14 x 14.5 x 2.5 cm removed along with axillary tissues sized 11 x 4.5 x 2 cm and a 11 x 5.6 cm skin flap. Weight 260 g. Tumour sized 1,2 x 10 x 1,0 cm found in the outer lower quadrant, 0.9 cm from the lower boundary, 0.5 cm  from the base and less than 0.1 cm from the parenchyma. Lymph nodes 1.8 cm in length. Microscopic description: Carcinoma ductale invasivum - NHG1 (2 + 2 +1: 5 mitoses/ 10 HPF, visual area diameter: 0.55 m). Calcifications within the tumour. Mamilla sine laesionibus. Glandular tissue showing lesions of the type mastopathia fibrosa (fibrocystic changes). Invasive lesions reaching the base.  AXILLARY LYMPH NODES Lymphonodulitis chronica et sinis histiocytosis No IX. Histopathology diagnosis: Carcinoma ductale invasivum mammae dextrae. (NHG1, pT1c, pN0). Invasive ductal carcinoma of the right breast Compliance validated by:
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diff --git a/output/text/4f04a68b-f1bc-474d-bd2b-c4154baa5aaa.txt b/output/text/4f04a68b-f1bc-474d-bd2b-c4154baa5aaa.txt
new file mode 100644
index 0000000000000000000000000000000000000000..463346730365aee8b543c834ad902ae5f1f13e87
--- /dev/null
+++ b/output/text/4f04a68b-f1bc-474d-bd2b-c4154baa5aaa.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+FINAL SURGICAL PATHOLOGYREPORT Diagnosis: A.-B.)RENAL MASS,RIGHT,AND BASE OF RIGHTRENAL MASS,RESECTION, -RENAL CELL CARCINOMA,PAPILLARYVARIANT, TYPEI. - Tumor measures 3.0 cm in greatest dimension. - Tumor confined to kidney. - No lymphovascular or perineural invasion identified. -MARGINS:INDETERMINATE (SEE COMMENT) -LYMPH NODES:NONE IDENTIFIED PATHOLOGIC TUMOR STAGING SUMMARY: Type and grade: Renal cell carcinoma, papillary variant, type I. Primary tumor: pT1a. Regional lymph nodes: pNX. Distant metastasis: pMX. Margin status: Indeterminate Pathologic stage:I. Lymphovascular invasion:Not identified Perineural invasion: Not identified. COMMENT: Immunohistochemical studies show that the tumor is positive for PAX-8, CD10, racemase, and EMA. It is negative for inhibin, CK5/6, p63, CK7, CK20,CD117, synaptophysin, and chromogranin. The staining patterns support the given diagnosis. All the immunohistochemical studies were interpreted hereat The inhibin stain is the only stain which was performed outside, at Due to the fragmented nature of the specimen, the margin status cannot be accurately determined by pathologic examination. Both specimen B and thethree cauterized fragments of renal tissue (in cassette A8) are free of tumor.I am not certain whether the combination of specimen B and the tissue in A8 is the completesurgical margin and whether or not it was fully overlying the pieces of specimenA that have tumor at the edge. Clinical correlation regarding the margin status is suggested. Kidney Tumor Staging Information Page 1 This report continues... (FINAL)
+
+--- Page 2 ---
+FINAL SURGICAL PATHOLOGY REPORT Data derived from current specimen. Staging in accordance with or modified from AJCCCancer Staging Handbook Procedure: Partial nephrectomy Portion of kidney Specimen type: Specimen laterality: Right. Tumor Features 3.0 cm in greatest dimension. Tumor size: Tumor focality: Unifocal. Renal cell carcinomapapillary variant, type l. Histologic type: Histologic grade (Fuhrman nuclear grade): N/A. Sarcomatoid features: Not identified. Macroscopic extent of tumor: Confined to kidney Microscopic tumor extension: Confined to kidney Lymph Nodes: None identified. Indeterminate Margin evaluation: Pathologic tumor staging descriptors Primary tumor: pT1a. Regional lymph nodes: pNX. Distant metastasis: pMX. Margin status: Indeterminate Pathologic stage I. Histologic findings in non-neoplastic kidney: None. Additional histologic findings: None. Comment: N/A.
+
+--- Page 3 ---
+FINAL SURGICAL PATHOLOGY REPORT A.Mass;right renal mass B.Mass;base of right renal mass Clinical History/Operative Dx: Right renal mass Gross Description: A. The specimen is labeled right renal mass and is received without fixative. It consists of an ovoid  fragment of renal tissue which measures 3 x 2.3 x 1.3 cm. The apparent cortical surface has a slightly  irregular contour and is dull red. The opposite surface (deep surface) shows a rim of prominent cautery artifact and approximately two-thirds of the deep surface has a torn and disrupted appearance with friable  tumor present. The cauterized portion of the deep margin of this specimen is inked blue. On serial sectioning of this specimen, there is a partially cavitary and very friable tumor mass present which. measures 2.5 x 1.7 x 1.4 cm.Also in the specimen container are multiple fragmentsof friable tan to light x 2 cm in aggregate and weighing 39 grams. The specimen container also has three additional fragments. of heavily cauterized renal tissue which vary from 1.1 x 0.7 x 0.3 cm to 1.7 x0.9 x 0.4 cm.Each of these fragments has focally cauterized surface.Sections of the adipose tissue reveal no grossly identifiable tumor. Representative sections of the tumor are obtained for research purposes. The entire resection of. kidney tissue is sequentially submitted in cassettes A1-A6. Representative sections of the separately submitted friable tumor are submitted in cassette A7. The smaller fragments of cauterized renal tissue are submitted in cassette A8 and representative sections of the separately submitted adipose tissue are submitted in cassette A9 B. The specimen is labeled base of right renal (tumor) mass and is received in formalin. It consists of five. fragments of dark brown to nearly black, heavily cauterized tissue which are 1 cm inaggregate. The. largest intact fragment measures 0.7 x 0.4 x 0.2 cm.The tissue is entirely submitted in cassette B1 Microscopic Description: A. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered. B. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered.
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diff --git a/output/text/4f56e59e-cd4e-4946-b05b-f68177208c63.txt b/output/text/4f56e59e-cd4e-4946-b05b-f68177208c63.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5e1e0bd7aad55d06bfc93533ffb15f5d9882c7f3
--- /dev/null
+++ b/output/text/4f56e59e-cd4e-4946-b05b-f68177208c63.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:4 0-381D-468C-AA30-F914F4F6589E Redacted Gross Description: In bladder, there are an invasive and protruded tumor, ill - margins with 2.5x2x2cm in size, soft and gray surface. Microscopic Description: Transitional cells are hyperplastic. Tumor cells arrange to form pappillary or trabeculae one by one. Tumor cells have moderate and eosinophilic cytoplasm. Nuclei are enlarged and varriability in shape and size, fairly irregular nuclear membranes, nucleoli and abnormal chromatin patterns. Mitoses are present. Tumor invades in superficial muscularis propria. Diagnosis Details: Infiltrating urothelial carcinoma, low-grade, infiltrating superficial muscularis propria Comments: Formatted Path Reports: BLADDER TISSUE CHECKLIST zcD-6-3 Carcuomi, transitonas Specimen type: Cystectomy Cei1 N6S 81Qo|3 Tumor site: Bladder Site: Bladder Nos C67.9 Tumor size: 2.5 x 2 x 2 cm QS xh/3 Tumor features: None specified Histologic type: Transitional cell carcinoma Histologic grade: Moderately differentiated Tumor extent: Superficial muscle (inner half) Lymph nodes: Not specified Lymphatic invasion: Absent Venous invasion: Not specified Margins: Uninvolved Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None
\ No newline at end of file
diff --git a/output/text/4f5caf72-7193-4c3f-a3f8-e26ad611fe96.txt b/output/text/4f5caf72-7193-4c3f-a3f8-e26ad611fe96.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6baeb501dacb5f313e0c0a9290ef307cd45e3cfe
--- /dev/null
+++ b/output/text/4f5caf72-7193-4c3f-a3f8-e26ad611fe96.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:CD86AS29-DE8B-48F6-A569-D07251D139C3 TCGA-OL-A66N-01A-PR Redacted Sample # FINAL PATHOLOGIC DIAGNOSIS A. Left breast, modified radical mastectomy: - Invasive lobular carcinoma, SBR grade II, see pathologic parameters and comment. - Lobular carcinoma in situ, classic type. - Metastatic carcinoma in thirteen of fifteen lymph nodes (13/15); biopsy. site present in one node Breast Pathologic Parameters. 1. Invasive carcinoma: A. Microscopic measurement: 6.6cm (slices 5-11); 20% cellularity. See comment. tad o3 B. Composite histologic (modified SBR) grade: II - Architecture: 3 - Nuclear grade: 2 8sQD/3 - Mitotic rate: 1 C. Associated lobular carcinoma in situ (LCIS): Sut  fBrsat NoSCso.1 - Within main mass and extending away Q 5/16|13 2. Excisional biopsy margins: Widely (>1cm) free of tumor 3. Blood vessel and lymphatic invasion: Absent. 4. Nipple and skin: unremarkable. 5. Axillary lymph nodes: Positive (13/15) - Size of largest metastatic deposit: 1cm - Extranodal extension: present, largest focus 2mm (multifocal) 6. Special studies (see - ER: Moderate to strong expression in 80% of invasive tumor nuclei. - PR: No expression of invasive tumor nuclei - HER2 antigen (FISH): Non-amplified (ratio: 1.10) 7. pTNM (AJCC, 7th edition, 2010): pT3, N3, MX. Clinical History:. The patient is a year-old female with breast cancer undergoing left breast. modified radical mastectomy. Comment The tumor exhibits 20% cellularity. Although extensive hyalinization is present
+
+--- Page 2 ---
+in the tumor bed, this feature was also seen on the pre-treatment biopsy. Hence, response to chemotherapy is difficult to assess. Of note, no significant treatment response is seen in the lymph nodes.. Specimens Received: A: Left breast modified radical mastectomy. Gross Description: A. The specimen is received in a single container labeled with the patient's name, medical record number, and additionally identified as, 'left breast  modified radical mastectomy'. Received fresh and placed in formalin is a 1,276.6 gm modified radical mastectomy specimen. The specimen is received oriented with a suture designating left axillary tail. The specimen measures 26.5 cm from superior to inferior, 27.5 cm from medial to lateral, and 5 cm from anterior to posterior. There is an attached 9.5 x 9 x 2.5 cm axillary tail. On the. anterior surface is a 23.5 x 13 cm tan-white ellipse of skin with a 6 x 5 cm areola and a 1.1 x 1 cm flattened nipple. The nipple-areolar complex reveals no evidence of ulceration or retraction.. The specimen is inked as follows: superior edge - blue; inferior edge - green; posterior - black. The specimen is serially sectioned from medial to lateral into 21 slices to reveal a firm, bulging, scallop tan-white to pink 8.5 x 6.5 x 4.2 cm mass in slices 5-13. The mass is 0.7 cm from posterior margin (black) and 0.5 cm from. anterior skin. A biopsy tract filled with gel is present in places 6-7, with clip present in slice 7. The remainder of the specimen consists of. approximately 5% dense gray-white fibrous breast parenchyma and 95% lobulated yellow adipose tissue. No additional masses or nodules are grossly identified. Sectioning through the axillary tail reveals multiple tan-brown, rubbery lymph. nodes ranging from 0.6 x 0.4 x 0.4- 2 x 0.9 x 0.5 cm in greatest dimension. Breast specimens are fixed for at least 6 hours in 10% NBF and no more than 72 hours. Block summary: A1: mass closest approach to posterior margin (black), slice 13 A2: mass, slice 12 A3: mass, slice 11 A4: mass, slice 10 A5: mass, slice 9
+
+--- Page 3 ---
+A6: mass closest approach to skin, slice 8. A7: mass biopsy tract, slice 7 A8: mass biopsy tract, slice 6 A9: mass, slice 5 A10: medial to lesion,slice 4 A11: medial to lesion, slice 14 A12: medial to lesion, slice 15 A13: upper-inner quadrant, slice 5 A14: upper-outer quadrant slice 12 A15: lower-outer quadrant slice 9 A16: lower-inner quadrant slice 4. A17: nipple A18: skin subjacent to nipple A19-A23: one lymph node candidate bisected in each cassette A24: three lymph node candidates A25: one lymph node candidate A26: three lymph node candidates A27-A29: one lymph node candidate bisected in each cassette MD.PhD
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diff --git a/output/text/4f5f5f64-a18d-439e-a5fa-8c770836f0d9.txt b/output/text/4f5f5f64-a18d-439e-a5fa-8c770836f0d9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b4c48f66aa557e9bf65535a704f604bb169647b2
--- /dev/null
+++ b/output/text/4f5f5f64-a18d-439e-a5fa-8c770836f0d9.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+DIAGNOSIS: 1. Renal, tumor #1, left, partial nephrectomy: Renal cell carcinoma, chromophobe type.. 2., Renal, tumor #4, left, partial nephrectomy: Renal cell carcinoma, chromophobe type.. 3. Renal, tumor #5, left, partial nephrectomy: Renal cell carcinoma, chromophobe type.. 4.  Renal, tumor #2, left, partial nephrectomy: Renal cell carcinoma, chromophobe type.  Renal, tumor #3, left, partial nephrectomy: Renal cell carcinoma, chromophobe type.. 6.  Renal, tumor #6, left, partial nephrectomy: Renal cell carcinoma, chromophobe type. 7. Renal, tumor #7, left, partial nephrectomy:  Renal cell carcinoma, chromophobe type.. 8.  Renal, tumor #8, left, partial nephrectomy: . Renal cell carcinoma, clear cell type, Fuhrman nuclear grade. II / Il. Renal cell Carcinoma, Chromophobe type. See note.. 9.  Renal, tumor #9, left, partial nephrectomy: Renal cell carcinoma, clear cell type, Fuhrman nuclear grade II / IIl. Renal cell carcinoma, Chromophobe type. See note.. NOTe: In specimens 8 and 9, two grossly and morphologically different tumor masses are identified; one is a clear cell RCC and the other one an RCC chromophobe type.. Patient Identification Page 1 of 5
+
+--- Page 2 ---
+Immunoperoxidase and in-situ hybridization tests performed here and used for diagnosis were developed and their performance characteristics determined by the They have not been cleared or approved by the U.s. Food and Drug. Administration. The FDA has also determined that such clearar nce or approval is not necessary. This laboratory is certified under the Clinical. Laboratory Improvement Amendments of (CLIA) as qualified to perform high complexity clinical laboratory testing.. CLINICAL INFORMATION: Brief Clinical History: yo male with bilateral renal tumors and no known family history of renal cancer, attention. PRoceDuRE: Pre-Operative Diagnosis: renal tumors Post-Operative Diagnosis: renal tumors Operative Findings: diffuse involvement of left kidney with. renal tumors; minimal normal parenchyma observed on intraoperative sonogram SPECIMENS SUBMITTED: 1. TUMOR, Left kidney # 1 (1FS) 2. TUMOR, Left kidney # 4 (2F$) 3. TUMOR, Left kidney # 5 (3FS) 4. TUMOR, Left kidney # 2 5. TUMOR, Left kidney # 3 6. TUMOR, Left kdieny # 6 7. TUMOR, Left kidney # 7 8. TUMOR, Left kidney # 8 9. TUMOR, Left kidney # 9 INTRAOPERATIVE CONSULTATION: 1. "Tumor #1 left kidney" 1FS diagnosis: Oncocytic neoplasm, favoring oncocytoma. 2. "Tumor #4 left kidney" 2FS diagnosis: Oncocytic neoplasm. 3. "Tumor #5 left kidney" 3FS diagnosis: Oncocytic neoplasm. These findings were reported by GROSS DESCRIPTION: Patient Identification Page 2 of 5
+
+--- Page 3 ---
+Received fresh from the OR is a specimen labeled with the patient's name, medical record number, and further specified as:. 1."tumor #1 left kidney". It is an ovoid red to pink nodular tissue fragment measuring 2 x 1.5 x 0.8 cm. It is. trisected revealing a pink-tan homogeneous cut surface. The central slice is frozen as "1Fs". Received in the Gross Pathology Lab is a specimen matching the above description. The portion submitted as frozen. section is transferred to an orange cassette labeled 1FS. A second of the trisected pieces is submitted in cassette labeled or permanent processing. 2. "tumor #4 left kidney". It consists of a red to tan 2.5 x 1.8 x 1 cm tissue fragment. It was trisected and the middle section is submitted as 2Fs. Received in the Gross Pathology Lab is a specimen matching the above description. The section submitted for frozen is transferred to an orange cassette labeled 2FS for permanent processing. Representative further sections are taken and submitted in cassettes 2A and 2B. 3."tumor #5 left kidney". It consists of a red-tan 5 x 5 x 3.5-cm tissue fragment. It was bisected to reveal a. red to tan hemorrhagic cut surface. Representative sections are frozen as 3Fs. Received in the Gross Pathology Lab is a specimen matching the above description. The frozen specimen was transferred to an orange cassette labeled 3FS for permanent processing. Cassettes 3A-3G contains representative sections of the tumor. "tumor #2 left kidney". It is a dome-shaped red to pink nodular tissue fragment measuring 2 x 1.4 x 0.7 cm. It is bisected revealing a homogeneous tan to pink cut surface with central hemorrhage. Approximately 60% of the tissue is procured for UOB. Gross photographs are taken and the remainder of the specimen is placed in formalin and submitted to Pathology for permanent processing. In the Gross Pathology Lab a specimen matching the above description is received. It is entirely submitted in a cassette labeled. )r permanent processing. 5."Tumor #3 left kidney". It is a dome-shaped red to pink nodular tissue fragment measuring 1.8 x 1.4 x 0.5 cm. It is bisected revealing a hemorrhagic maroon/red cut surface. Approximately 50% of the tissue is procured for UOB. Gross photographs are taken and the remainder of the specimen is placed into formalin and submitted to Pathology for permanent processing. Received in the Gross Pathology Lab is a specimen matching the above description. A representative section is submitted in a cassette labeled r permanent processing. 6."Tumor #6 left kidney". The specimen is a spherical pink to red nodular tissue fragment measuring 4.8 x. 4.8 x 4.7 cm. It is bisected revealing a focally disrupted tan to pink nodular tissue fragment that is homogeneous. The surface is tan to pink and fleshy. Approximately 30% of the tissue is procured for UOB. Gross photographs are taken and the remainder of the specimen is placed into formalin and submitted to Pathology for permanent processing. Received in the Gross Pathology Lab is a specimen. matching the above description. Representative sections are submitted in cassettes 6A-6E. Cassette 6A. Patient Identification Page 3 of 5
+
+--- Page 4 ---
+contains a portion of adjacent tissue that has a distinct smooth creamy texture compared to the rest of the lesion.  "Tumor #7 left kidney". The specimen consists of 2 fragments that are red to tan soft tissue and 1 yellow to pink soft tissue fragment measuring from 2.5 to 4.5 cm in greatest dimension. The largest fragment is bisected revealing a variegated maroon to pink hemorrhagic cut surface measuring 4.5 x 3.5 x 3. Approximately 50% of tissue from the largest fragment is procured for UOB.  Gross photographs are taken and the remainder of the specimen is placed into formalin and submitted to Pathology for permanent processing.  Received in the Gross Pathology Lab is a specimen matching the above description. Representative sections are taken and submitted in cassettes labeled 7A-7F for permanent processing. 8. "Tumor #8 left kidney" is a focally disrupted ovoid pink to tan nodular tissue fragment measuring 5.5 x 5 x 3.5 cm. It is bisected revealing a tan-pink fleshy cut surface with a well-circumscribed yellow to tan spherical nodule, 1.2 cm in greatest diameter, at the periphery. Approximately 50% of the tissue. spherical tan nodule, and 20% of the rest of the specimen are procured. The remainder of the specimen is placed into formalin and submitted to Pathology for permanent processing. Received in the Gross Pathology Lab is a specimen matching the above description. Representative sections of the specimen are taken and submitted in cassettes 8A-8E. Please note that 8E contains a representative section of the nodule described. 9. "Tumor #9 left kidney". It is a binodular pink to tan tissue fragment overall measuring 2 x 1.5 x 1.5 cm. One nodule is well-circumscribed and solid homogeneous and tan measuring 1.3 cm. The other is ill- defined, hemorrhagic, and variegated maroon to tan and measuring 1.2 cm. Approximately 50% of tissue is procured for UOB. Gross photographs are taken and the remainder of the specimen is placed into formalin and submitted to Pathology for permanent processing. Received in Pathology is a specimen matching the above description. The two fragments are submitted in white cassettes labeled 9A and 9B AZR Identification 4 of 5
+
+--- Page 5 ---
+Patient Identification Surgical Pathology Report  NIH-2772 (7/97) P.A. 09-25-0099 File in Section 3: Tissue Examination Page 5 of 5
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diff --git a/output/text/4fad3143-8901-46d4-ba1d-87e6c7cd164e.txt b/output/text/4fad3143-8901-46d4-ba1d-87e6c7cd164e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..54b0f2e1eac77913ae2582a4541be9ebee75d01e
--- /dev/null
+++ b/output/text/4fad3143-8901-46d4-ba1d-87e6c7cd164e.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+SURGICAL PATHOLOGY Surgical Pathology Report. Diagnosis: Colon, right, resection. Tumor Histologic Type: Adenocarcinoma with prominent mucinous and signet ring cell features; see comment. Histologic Grade: poorly differentiated Tumor Location: ascending colon Depth of Invasion: -Through muscularis propria into the pericolic soft tissue Lymphovascular Invasion: present, extensive Perineural Invasion: not identified Margins: Proximal margin: Negative for malignancy. Distal margin: Negative for malignancy Mesenteric margin: Negative for malignancy. Distance of carcinoma from closest margin (specify): tumor is 2.0 cm from the mesenteric margin. Regional Lymph Nodes: Twelve of fourteen lymph nodes positive for metastatic poorly differentiated adenocarcinoma, 1.0 cm in greatest dimension, extracapsular extension present (12/14). Additional pathologic findings: - Appendix with mucin and tumor cells within periappendiceal soft tissue and extending into muscularis propria of appendix. - Severe acute and chronic serositis with adhesions.. AJCC PATHOLOGIC TNM STAGE: pT3 pN2b Note: This pathologic stage assessment is based on information available at the time of this report, and is subject to change pending clinical review and additional information.. Comment: Immunohistochemical stains for MLH1, MSH2, and MSH6 are performed. The tumor demonstrates appropriate nuclear staining for all three markers which is the normal phenotype and which does not support a diagnosis of hereditary non-polyposis colorectal cancer. Microsatellite instability testing will be performed by the Lab and reported separately.. Clinical History: right colon cancer.. Gross Description: Specimen fixation: formalin Parts of bowel received/ Specimen length: colon (17 cm in length, 6.7 cm in circumference); ileum (10.7 cm in length, 3.4 cm in circumference); appendix with a length of 3.5 cm and a diameter of 0.9 cm Orientation: The distal colonic margin is inked black, the ileal margin is inked blue, the surrounding fat over the tumor is inked green. Tumor location: 4.2 cm from blue inked margin and 12.7 cm from black inked margin.
+
+--- Page 2 ---
+Gross appearance of tumor: Ulcerated, hemorrhagic, firm, tan/white Tumor dimensions: 7.5 cm x 5.5 cm x 5.0 cm. Circumferential growth: 50% of luminal circumference involved Gross depth of invasion: Tumor invades grossly into the fat. There are multiple separate tumor nodules/candidate lymph nodes which are present in the pericolonic fat and measure up to 3.5 cm. Gross evidence of perforation through visceral peritoneum: no Luminal obstruction: approximately 70% Bowel circumference at tumor site: 4.5 cm Gross distance of tumor from margins: 4.2 cm from the blue inked margin, 12.7 cm from the black inked margin, 2.0 cm from perpendicular soft tissue margin Lymph nodes: per block summary Other remarkable findings: multiple tumor nodules and surrounding fat; The appendix wall is thickened (0.4 cm) and the mucosal surface is tan. The tip of the appendix is dilated with a maximum diameter of 1.1 cm. The internal surface is tan/pink and regular. Tissue submitted for special investigation: yes, to Tissue Procurement Digital photograph taken: not taken Block summary: (Inking scheme: ileal margin=blue, colonic margin=black) A1 - ileal margin, en face (inked blue) A2 - colonic margin, en face (inked black) A3 - soft tissue/vascular margins overlying tumor A4 - representative sections of appendix (cross sections) A5 - representative section of tumor, perpendicular to mucosa. A6 - representative section of tumor (perpendicular to mucosa) with pericolonic fat A7 - tumor with pericolonic fat A8 - tumor nodule with pericolonic fat (inked green) A9 - tumor nodule with pericolonic fat (inked green) A10 - representative section of tumor A11 - representative section of tumor with pericolonic fat. A12 - representative section of tumor A13 - three lymph node fragments/candidate tumor satellites A14 - two lymph node fragments A15 - two lymph node fragments A16 - one lymph node fragment A17 - two lymph node fragments A18 - two lymph node fragments A19 - one lymph node fragment, bisected A20 - one lymph node fragment, bisected A21 - one lymph node fragment, bisected A22 - two lymph node fragments A23-A24 - one lymph node fragment, trisected A25 - two lymph node fragments A26 - three lymph node fragments A27 - four lymph node fragments A28 - tip of appendix, longitudinal
+
+--- Page 3 ---
+Grossing Pathologist: Light Microscopy: Light microscopic examination is performed by Dr. For cases in which immunostains are performed, the following applies: Appropriate internal and/or external positive and negative controls have been evaluated. Some of the immunohistochemical reagents used in this case may be classified as analyte specific reagents (AsR). These were developed and have performance characteristics determined by the. These reagents have not been cleared or approved by the US Food and Drug Administration. (FDA). The FDA has determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of alified to perform high complexity clinical laboratory testing.. Signature Attending Pathologist: I have personally conducted the evaluation of the above specimens and have rendered the above. diagnosis(es).
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diff --git a/output/text/4fec8f6e-6ac9-4d32-ba47-2eb657dd0b5a.txt b/output/text/4fec8f6e-6ac9-4d32-ba47-2eb657dd0b5a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..99fdfe52f8d1581c53896b9d4067db0f54d64b8e
--- /dev/null
+++ b/output/text/4fec8f6e-6ac9-4d32-ba47-2eb657dd0b5a.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UUID:E52D8CCE- 6A49-4A72-966E-FA396483F0CC TCGA-LN-A5U6-01A-PR Redacted zCD-t-3 Clinical Case Report Ocins ro- gusmws cell N6S (For C ssue) 8670f3 Lewer third if esghgus C16.5 @CF Distal~thi^d.of tphaq4s C15S S 416/13 Informed Consent I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the 'EARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator Clinical Information GENERAL INFORMATION Date of Birth (mm/dd/yyyy) Height. Marital Status Race Temperature In2  Single Married Vietnamerx 37 Gender Weight  Divorced  Widow Blood Pressure Heart Rate Male  Female 15/8 82 HISTORY OF PRESENT ILLNESS Chief Complaints: yau, Tmib l. Swallowing Symptoms: 0o35, Thutle np1`q h t Clinical Findings: Performance Scale (Karnofsky Score):.  100 Asymptomatic  80-90 Symptomatic but Fully Ambulatory 60-70 Symptomatic, in bed less than 50% of day  40-50 Symptomatic, in bed more than 50% of day, but n6t bed ridden  20-30 Bed Ridden CURRENT MEDICATIONS Drug Dose Route Frequency Date (mm/dd/yyy) To To To To To
+
+--- Page 2 ---
+PAST MEDICAL HISTORY Dlagnosis/Disease/Disorder/Injury Diagnosis Date Treatment Status OB/GYN HISTORY Menopausal Status Date of First Menses # of Pregnancies  Pre-menopausal  Peri-Menopausal Date of Last Menses # of Live Births  Post-menopausal Birth Control:  Condom  Oral Contraceptive DIUD  Hormone Replacement  Other: Therapy: SOCIAL HISTORY Occupation: Environmental Hazards: Smoking History Current Status TypE  Packs/day Duration When Quit  yeS NO ratle /day 24 (yrs) (yr) Alcohol Consumption Current Status TYPE Drinks/day Duration When Quit  YES NO 112 diuc/day 3? (yrs) 112 (yr) Drug Use Current Status TyPE Frequency Duration When Quit  yES NO (yrs) yr FAMILY MEDICAL HISTORY  Relative Dlagnosis Age of Diagnosis LAB DATA Test Result Date Test  Result Date HIV sNegative  Positive: CEA  Negative  Positive: Hep B Negative  Positive: CA 15-3 Negative  Positive: Hep C Negative  Positive: CA 19-9   Negative  Positive: AFP  Negative  Positive: PSA  Negative  Positive: Other: Other: Negative  Positive: Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+DIAGNOSTIC STUDIES Study Results Date Ultrasound X-Ray CT Endoscopy MRI Biopsy Sqwammw?..cell Cor ca'rmy CLINICAL DIAGNOSIS Preoperative Clinical Diagnosis t8ozsrrqeaz Caneer Location of Suspected Involved Lymph Nodes. Location of Suspected Distant Metastasis. Clinical Staging Date of Diagnosis t2 Nj MO Stage:  B Treatment Information SURGICAL TREATMENT Procedure Date of Procedure. Reechm tL 1i2 e,onhAefU) Primary Tumor Organ. Detailed Location Size esopaqus. Temer loweg FhiAd  x 3 x2 cm Extension of Tumor Lymph Nodes Description Location of Lymph Nodes # of Lymph Nodes Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Organ Detailed Location Size Surgical Stagingd T 2. N.s. M e Stage: II B NEOADJUVENT THERAPY (Chemo, Radiation, Immuno, Hormonal, or Molecular) Dose Route Frequency Date (mm/dd/yyyy) Drug/Treatment To To To To 1 1 To 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by: -- Date:  'ime... Preserved by: -- Date: fime... SPECIMEN TYPE (# of samples provided) Frozen Paraffin Block Blood/Serum/Plasma Slide Diseased Normal Diseased Normal Diseased Normal Diseased Normal 4 2. + 2. 2. Time to LN2 Time to Formalin Time to LN2 min min min PATHOLOGICAL DESCRIPTION  Primary Tumor  Organ Size Extension of Tumor Distance to NAT escpbaausZ.smcR < x 3 x Zcm|2 Izen thire? 6 cm Lymph Nodes # Examined # Metastasized Distant Metastasis Organ Detailed Location Size Pathological Staging pTz. NA m o Stage: Notes: gpnfc nco/es 2 C posst've1, NeF>F've 1 4
+
+--- Page 5 ---
+Consolidated Pathology Diagnosis HisologcdPattern Cell Distribution + Structural Pattern + Diffuse  Streaming  Mosaic X  Storiform Necrosis x Fibrosis Lymphocytic Infiltration  Palisading  Vascular Invasion Cystic Degeneration Clusterized X Bleeding  Alveolar Formation  Myxoid Change Indian File Psammoma/Calcification Squamous Adenomatous + Sarcomatous Lymphomatous Squamoid Cell X  Glandular cell Round Cell  Large Cell Spindle Cell Cell Stratification Fibroblast Small Cell  Keratin  Secretion Osteoblast  RS Cell/RS Like Desmosome Intracyt. Vacuole Lipoblast Inflam. Cell Pearl Gland formation Myoblast  Plasma Cell Cellular Differentiation:  Well Moderate  Poor NudearAppaaranced Nuclear Atypia: 0 1. II III Aniso Nucleosis Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell C Mitotic Activity X Nuclear Grade: Final Pathology Report Histological Diagnosis: Sas Qnozze Cel/ C2.eeirI'ss. Grade: 2 Comments: D1 60h D2687 D3607 Dybif Weeno%r Date lw 0/17/!3 INTEGRATED REPORT OF FINDINGS BY'
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diff --git a/output/text/4ff54a32-12fb-4f66-8c98-ca684045159c.txt b/output/text/4ff54a32-12fb-4f66-8c98-ca684045159c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..88532b6b8dac81cee0524bbe8bcc12b5738c4f6c
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1CA -0r3 Carcn`oma irothlil 8r20f3 Ste. bladduw, trigon Patient hIstory: Cb7.0 None given. 4/7/1 M PRE-OP DIAGNOSIS: Bladder cancer. POST-OP DIAGNOSIS: Same. PROCEDURE:  Radical cystectomv. UUID:F1C2F8C6-C3F6-4E69-90FE-E55A44571779 FINAL DIAGNOSIS: TCGA-BT-A20U-01A-PR Redacted PART 1: Lymph nodes, right pelvic, excision --  NO EVIDENCE OF CARCINOMA IN FIVE (6) LYMPH NODES EXAMINED. PART 2: Lymph nodeS, Left pelviC, excIsiOn -- NO eViDENCE OF CARC(NOMA iN TWO (2) LyMPH nODES EXAMINED. PART 3: Right pelvic cyst, excision -- LeiomyOmA wITh hyaLiNizaTiOn AND DEgeNErAtiOn. PART 4: BLADDeR, UTerUS, BILATeral FaLLOpian TUBeS And OVarIeS, RADical CystecTOmy, hySterEcTOmy, AnD  BILATEraL SALpinGO-OOphOrecTOmy - A.  INVASIVE UROTHELIAL CARCINOMA (3.5 CM), HIGH GRADE (WHO/ISUP). B. CARCINOMA INVADES THE DETRUSOR MUSCLE (INNER AND OUTER) AND PERIVESICAL FAT. C. SURGICAL MARGINS ARE FREE OF TUMOR. D. NO CARCiNOMa in SITU IS iDenTIFIED. E.  PERINEURAL INVASION IS IDENTIFIED. F.  NO ANG!OLYMPHATIC INVASION IS IDENTIFIED. G. TNM PATHOLOGIC STAGING = T3a N0 MX. H. Tnm histopatholOgic Grade = G3. i. EXTeNSIVE SQUAMOUS METAPLASIA WITh HYPERPLASiA AND REACTIVE ATYPIA. J. VAgInA iS fREE Of TumOR. K. CERVIX SHOWS MULTiPLE NABOTHIAN CYSTS AND IS FREE OF TUMOR. Uterus Shows atrophic endometrium, Leiomyomata, AnD is free Of tumoR. M.  FALLOPiAn TUBES AnD OVARieS SHOW nO SPECIFIC PAThOLOGIC ABnORmALiTy , FREE OF tUmOR. Part 5: Lymph nooes, right pelvic, excision - NO EVIDENCE OF CARCINOMA iN ONE (1) LyMPH NODE. PART 6: Distal ureteral margin, Right, Excision --  NO EVIDENCE OF CARCINOMA. PART 7: Distal ureteral margin, Left, excision - NO EVIDENCE OF CARCINOMA. CASE SYNOPSIS:  SyNOPTiC DATA - PRImARY URINARY BLADDER TUMORS SPeCimen Type: Other: Hysterectomy & Salpingo oophorectomy Tumor Site: Trigone. Right tateral wall, Left lateral wall Tumor size: Greatest dimension: 3.5 cm Additional dimensions: 3.5 x 1 cm HISTOLOGIC TYPE:  Urothelial (transitional cell) carcinoma ASSOCIATED EPITHELIAL LESIONS: None identified HISTOLOGIC GRADE: Urothelial carcinoma - High-grade TUMOR CONFIGURATION: Ulcerated PATHOLOGIC STAGING (pTNM): pT3a pNO Number of nodes examined: 8 pMX MARGINS:  Margins uninvolved by invasive carcinoma Distance of tumor from closest margin: 5 mm Margin: Anteriar VENOUS/LYMPHATIC (LARGE/SMALL) VESSEL INVASION (V/L): Absent DIreCt exTensiOn Of invasive tumOR:  None identified ADDITIONAL PATHOLOGIC FINDINGS: Cystitis cystica glandularis Other: Extensive squamous metaplasia
\ No newline at end of file
diff --git a/output/text/4ff6ccf2-0d3a-4855-9503-b1226074c4a3.txt b/output/text/4ff6ccf2-0d3a-4855-9503-b1226074c4a3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..43dc9e810144bcfc848ff6d1b9046babda696db5
--- /dev/null
+++ b/output/text/4ff6ccf2-0d3a-4855-9503-b1226074c4a3.txt
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+
+--- Page 1 ---
+UUID:42179876-80ED-42D0-A4EF-FAAE374E77BA TCGA-2Z-A93K-01A-PR Redacted Pathology Report Final Diagnosis A. LEFT KIDNEY, NEPHRECTOMY: Renal cell carcinoma, papillary type ll. See Key Pathologic Findings. Surgical margins, free of malignancy. Pathologic stage: pT3a NX MX. the attending pathologist, personally reviewed all siides and / or materials and rendered the final diagnosis. Electronically Signed out by Key Pathological Findings TDC3 A: Kidney Resection PROCEDURE: Carcintns, yolplloey ^ena SPECIMEN TYPE: Nephrectomy SPECIMEN LATERALITY: usQ 8Q6o|3 Left TUMOR SIZE (largest tumor if multiple): Dimension: 8.7 cm Bik D Kidney NoS Cb4.9 MACROSCOPIC EXTENT OF TUMOR: Tumor extension into petvic fat Q)412814 HISTOLOGIC TYPE:  Papillary renal cell carcinoma SARCOMATOIDFEATURES: Not identified TUMOR NECROSIS: 10% HISTOLOGIC GRADE (Fuhrman Nuclear Grade) G3:Nuclei very irregular,approximately 20 microns;nucleoli large and prominent MICROSCOPIC TUMOR EXTENSION: Tumar extension into renal sinus Tumor extension into pelvic fat MARGINS: Vascular, ureteral and surgical margins, uninvolved by carcinoma ADRENAL GLAND: Not present  PERINEURAL INVASION: Absent ANGIOLYMPHATIC INVASION: Absent LYMPH-VASCULAR INVASION: Absent PRIMARY TUMOR (pT): pT3a: Tumor extends into renal pelvic fat
+
+--- Page 2 ---
+REGIONAL LYMPH NODES (pN): pNX: Regional lymph nodes cannot be assessed. DISTANT METASTASIS (pM): pMX Specimen(s) Received A LEFT KIDNEY Preoperative Diagnosis. Left renal mass. Gross Description A. The specimen is received fresh, labeled *left kidney" and consists of a kidney with partial encapsulated perinephric tissue, 844.0 g. 19.5 x 9.8 x 8.6 cm. The specimen is inked black. The adrenal gland is not identified.. The cut surfaces exhibit an irregular tumor mass involving the cortex and medulla in the superior, middle and inferior poles, 8.7 x 7.6 x 7.2 cm. The tumor is variegated, pale tan-pink and soft with smooth lobulated sections. Marked fibrotic septation is noted. Neither necrosis, hemorrhage or cystic. degeneration is identified. The tumor invades 90% of the calyceal system and extends to the hilum. The renal vein, artery and ureter are probe patent,and not involved by tumor. The tumor does not appear to invade the renal sinus, nor penetrate through the renal capsule to involve the perinephric fat.. The tumor is sharply demarcated from normal parenchyma. Satellite tumor nodules are not present.. The remaining renal parenchyma is pink-tan, smooth and glistening with a well-demarcated cortico-medullary junction, 1.5 cm thickness. The papillae are blunted. A segment of attached ureter. is noted (4.5 cm length x 4 mm diameter). The renal artery reveals no significant atherosclerotic changes. No lymph nodes are identified. Representative sections are submitted in A1-A14 as. labeled: A1: Mirror image section of tumor tor Tissue Procurement Laboratory A2. Renal vein and artery with ureter resection margin, tangential A3-A4: Tumor with inked perinephric fat margin. A5-AT: Tumor, renal pelvis, pelvic fat and normal parenchyma A8-A11:Tumor and hilum in relation to renat artery and vein with ureter A12-A13: Tumor with septated fibrotic tissue A14: Normal renal parenchyma The specimen is submitted for Tissue Procurement Laboratory. Dual/Syn
\ No newline at end of file
diff --git a/output/text/4ff9677a-35c2-41c5-a2c7-0b68de69f7f2.txt b/output/text/4ff9677a-35c2-41c5-a2c7-0b68de69f7f2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7cf2808aa6c48ddfdb29793e24cc17c46d109922
--- /dev/null
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+
+--- Page 1 ---
+UUID:CAA50817-CBA3-4AE7-8B1 TCGA-FD-A3SM-01A-PR Redacted Gender: Male DOB: Race: Report Date: 1cD-o-3 carcinomg,urnlia1,D5 Pathology Report: 8iaOj3 Sif: Surgical Pathology Report poh: b{addler,DS FINAL PATHOLOGIC DIAGNOSIS <67.9 A. Right pelvic lymph nodes; biopsy:. CQXF: bladd,wai1, Igkra1 - Eight benign lymph nodes (0/8). B. Left pelvic lymph nodes; biopsy: C&7.r - One lymph node with metastatic urothelial carcinoma (1/1). 4-1-1Z - No extranodal extension. C. Left pelvic lymph nodes; biopsy: k p - Three of sixteen lymph nodes with metastatic urothelial carcinoma (3/16). - No extranodal extension. D. Bladder and prostate; radical cystectomy:. - Invasive urothelial carcinoma, see parameters.. E. Right distal ureter, resection:. - Fragment of ureter, no tumor.. Urothelial Carcinoma Pathologic Parameters 1. Tumor type: Papillary urothelial carcinoma 2. Grade of tumor: High grade 3. Depth of invasion: Extravesicular soft tissue 4. Tumor distribution: Solitary, 9 x 6.5 x 3 cm Dome Right lateral wall Left lateral wall Anterior wall Posterior wall 5. Ureteral margins: Negative 6. Distal urethral margin: Negative 7. Soft tissue margin or serosa: Negative (< 1 mm from cauterized and inked
+
+--- Page 2 ---
+margin) 8. Lymph nodes: Positive left pelvic lymph nodes (4/17), negative right pelvic. 1ymph nodes (0/8) 9. pTNM: pT3a, N2 Effective this Checklist utilizes thee.  edition TNM staging system for Bladder of the American Joint Committee on Cancer (AJCC) and the International Union Against Cancer (UICC). xxx [}, m.D. Interpretation performed by the Attending Pathologist and reviewed with the. Resident/Fellow, [] MD Electronically Signed Out by [], M.D. Clinical History: The patient is a -year-old male with malignant neoplasm of bladder undergoing a radical cystectomy with Neo-bladder. Specimens Received: A: Right pelvic lymph nodes B: Left pelvic lymph node C: Left pelvic lymph nodes D: Bladder, prostate E: Right distal ureter, stitch on non-margin side Gross Description: The specimens are received in five containers each labeled with the patient's name and medical record number. A. The first container is additionally identified as, "1. Right pelvic lymph nodes". Received fresh and placed in formalin is a 7 x 6 x 2 cm aggregate of yellow-tan fibrofatty tissue. 10 lymph node candidates are identified ranging from 0.3 x 0.2 x 0.2 cm to 2 x 1 x 1 cm. The lymph node candidates are submitted as follows: A1-A2: 3 lymph node candidate in each cassette A3: 2 lymph node candidates A4: 1 serially sectioned lymph node candidate A5-A6: 1 serially sectioned lymph node candidate B. The second container is additionally identified as, "2. Left pelvic lymph node". Received fresh and placed in formalin is a 12 gm, 5.0 x 3.5 x 2.5 cm pink-tan nodule consistent with lymph node. The lymph node candidate is serially. sectioned to reveal white-tan and firm focal with cystic and necrotic tissue.
+
+--- Page 3 ---
+The specimen is representatively submitted for frozen section diagnosis and read. as "one lymph node frozen, positive for carcinoma, approximately 2 cm" per Dr. {l. The frozen section remnant is submitted in blocks B1FS-B2FS. Representative sections are submitted as follows: B1FS-B2FS: Frozen remnant B3: Section of lymph node. C. The third container is additionally identified as, "3. Left pelvic lymph nodes". Received fresh and placed in formalin is a 7 x 5 x 2 cm aggregate of yellow-tan fibrofatty tissue. 18 lymph node candidates are identified ranging from 0.4 x 0.3 x 0.2 cm to 2 x 1.5 x 1 cm. The lymph node candidates are submitted as follows: C1-C2: 4 lymph node candidates in each cassette C3-C4: 3 lymph node candidate in each cassette C5: 1 serially sectioned lymph node candidate. C6: 1 serially sectioned lymph node candidate C7-C8: 1 serially sectioned lymph node candidate C9-C10: 1 serially sectioned lymph node candidate D. The fourth container is additionally identified as, "4. Bladder, prostate". Received fresh and placed in formalin is a 525.1 g, 16.5 x 11.5 x 5.5 cm cystoprostatectomy specimen consisting of a 9.0 x 8.5 x 4.0 cm bladder with attached pericystic adipose tissue and a 5.5 x 4.5 x 3.5 cm prostate. The right seminal vesicles measure 5.5 x 2.0 x 0.8 cm and right vas deferens measures 15.5 cm in length by 0.2-0.5 cm in diameter. The left seminal vesicles measures 4.5 x. 1.8 x 0.8 cm and left vas deferens measures 13.5 cm in length by 0.2-0.7 cm in diameter. The right ureteral stump measures 1.4 x 0.5 cm, the left measures 1.1 x 0.5 cm, and the urethral stump measures 1.4 x 0.7 cm, which demonstrate intact, patent lumens. The right half of the prostate is inked blue, the left half is inked black, and. the reminder of outer surface of the specimen is inked black. The bladder and prostate are opened along the posterior aspect due to the location of the bladder tumor. The prostate is surrounded by thin, shaggy membranous tissue and sectioning demonstrates rubbery, pink-tan, and spongy with no discrete masses and indurations. The opened bladder reveals a 9.0 x 6.5 x 3.0 cm fungating, shaggy, gray-tan firm to friable mass occupying the entire anterior and lateral walls of the right and left sides. Approximately 30% of the posterior wall is also involved. On cut section, the mass is diffusely solid and white-tan with focal yellow-tan areas consistent with necrosis. The mass extends through the muscularis propria and focally abuts the deep margin with a maximal wall thickness of 3.0 cm, and located 3.5 cm from the urethral margin. The remaining surrounding bladder mucosa is wrinkled, white-tan with a uniform
+
+--- Page 4 ---
+1.1 cm wall thickness. Bilateral ureteral orifices, adjacent to the trigone, are identified and probe patent.. The pericystic adipose tissue is dissected for lymph node candidates. No lymph nodes are identified.. Also received is a detached vessel 5.0 cm in length by 0.2-0.3 cm in diameter. Gross photographs are taken. Representative sections are submitted as follows: D1: Right ureter resection margin. D2: Left ureter resection margin. D3: Distal urethral margin D4-D5: Apical prostatic margin, perpendicularly sectioned D6-D7: Bladder mass, including deep margin (tandem sections) D8: Bladder mass and uninvolved mucosa, anterior wall. D9: Bladder mass and uninvolved mucosa, dome D10-D11:Additional bladder mass D12: Uninvolved bladder mucosa, dome. D13: Uninvolved bladder mucosa, posterior wall D14: Uninvolved trigone D15: Representative prostate through verumontanum D16: Representative prostate above verumontanum D17: Bilateral seminal vesicles and vasa deferentia E. The fifth container is additionally identified as, "5. Right distal ureter, stitch on non-margin site". Received fresh and placed in formalin is a 1.5 cm in length and 0.6 cm in diameter tubal structure consistent with ureter. A stitch is designating non-margin side, and opposite side is inked blue. The specimen is sectioned to reveal a 0.3 cm lumen and a wall thickness 0.2 cm. The outer surface of the specimen is pink-tan to yellow-tan, and shaggy. The inner surface is gray-tan and smooth. The marginal side is submitted en face as E1. xxx [] Intraoperative Consult Diagnosis: B1FS-B2FS: "one lymph node frozen, positive for carcinoma, approximately 2 cm" per Dr. []
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diff --git a/output/text/500baae5-06e1-4e21-a36c-c03e69195171.txt b/output/text/500baae5-06e1-4e21-a36c-c03e69195171.txt
new file mode 100644
index 0000000000000000000000000000000000000000..99191a5031b6515f067f924124d2239cd712d268
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+
+--- Page 1 ---
+UUID:D8DA2A5D-2CE1-4B6C-8EE6-DE5760EE24C9 TCGA-DW-7963-01A-PR Redacted MEDICAL RECORD Surgical Pathology Report Surgical Pathology Report PATIENT: MRN: ACCOUNT#: Received Date: DoB: PROCEDURE DATE: AgE: SEX: M SIgn-out Date: ATTENDING: LOCATION: REQUESTING: 11 CONTACT NO: Room: COPIES TO: DIAGNOSIS: 1. Soft tissue, right paracaval mass, resection (1Fs): Lymph node, no turmor seen (0/1). 2.Lymph node, right hilar, resection (2Fs): Nerve and ganglla.. 3. Right renal mass, deep margin, resection: Renal parenchyma, no tumor seen. 4. Kidney, right, mass, partial nephrectorny: Renal cell carcinoma, papillary Type t, with extensive necrosis and hemorrhage. inked margin af resection is negative for tumor. See Note.. 5. NOTE: Surglca! Pathology Cancer Case Summary (Checkllst)d KIDNEY: Nephrectomy, Partial 1CO-0-3 Procedure (Note D) Partial nephrectomy Speclmen Laterality 8260|3 Right Site:Edny,Nos C44.9 Tumor Size (largest tumor If multiple) Greatest dimenslon: 4.6 cm *Additional dIrnensions: 4.1 x 1.3 cm h Tumor Focality 10f24f1> Unifocal Macroscopic Extent ot Tumor (select all that apply) (Note E) Tumor limited to kidney Histologlc Type (Note A) Papillary renal cell carcinoma Patient Identification Surgical Pathology Report Fie in Page 1 ot 4
+
+--- Page 2 ---
+MEDICAL RECORD Surgical Pathology Report Name: Mrn: Date of Report: Sarcomatoid Features (Note B) Not identified *Tumor Necrosls (any amount) *Present Histologic Grade (Fuhrman Nuclear Grade) (Note C) G2: Nuclei slightty irregular, approximately 15 m; nucleoli evident. Microscoplc Tumor Extension (select all that apply). Tumor limited to kidney Margins (selact all that apply) (Note F)  Margins uninvoived by invasive carcinoma Pathologic Staging (pTNM) (Note G) TNM Descriptors (requlred only if applicable) (select all that apply). pT1b: Tumor more than 4 cm but not more than 7 cm in greatest dimension, limited. to the kidney  Regional Lymph Nodes (pN) pNO: No reglonal Iymph node metastasis Distant Metastasis (pM) Not applicable Pathologic Findings in Nonneoplastlc Kldney (seiect all that apply) (Note H) Insufficient tissue (partiai nephrectomy specimen with <5 mm of adjacent nonneoplastic kidney) Immunoperoxdase and in-situ hybridization tests performed here and used for dlagnosis were developed and thelr poriormance characteristics determined by the Laboratory of Pathology. They have not been cleared or approved by the U.s. Food and Drug. Administration. The FDA has also determined that such clearance or approval is not necessary. Thls laboratory is certified under the Clinical Laboratory Improvemant Amendments of 1988 (CL!A) as qualifed to perform high complexity cHnical laboratory testing.d CLINICAL INFORmATION: Allocate Order to Protocol: Brief Clinical History: Right  Renai Mass, Gross Hematuria Specimen Taken For Protocol: 01 - Yes PROcEDuRe: Pre-Operative Dlagnosis: Right Renat Mas Post-Operative Diagnosis:. same Operative Findings: Solitary right renal mass with invasion into collecting system, suspicous lymph node in renal hilum. SPECIMENs SUBMITTeD: 1. ROuTINE + 4FS, Right paracaval mass (1FS) 2. ROUTINE + 3FS, Right hilar lymph node (2FS) Patient Identification  Suraical Pathnlogy Report File in Page 2 of 4
+
+--- Page 3 ---
+MEDICAL RECORD Surgical Pathology Report Name: MRN: Date of Report: 3. KiDNEY, Right rena mass deep margln. 4. KIDNEY, Right mass InTRAOPERATIVE CONSULTATION: 1FS *Right paracaval mass" 1FS diagnosis: Lymph node, no tumor seen.. 2FS *Rlght hilar lymph node". 2FS diagnosis: Ganglia. The frozen sectlons are diagnosed by. GROSS DESCRIPTION: Received 4 containers labeled with the patient's name, medical record number, and. further specified as follows:  *Right paracaval mass 1FS" consists of a tan-pink soft tissue fragment measuring 0.3 x 0.3 x 0.3 cm. The. specimen is totally frozen as 1Fs. in Surgicai Pathology, the specimen received matches the above descrlption. The frozen sample is transferred to an orange cassette labeled :. 1FS for permanent processing. 2.*Right hilar lymph node" consists of a tan-pink soft tissue fragment measuring 0.8 x 0.4 x 0.3 cm. The specimen is totally trozen as 2Fs. In Surgical Pathology. the specimen recelved matches the above. description. The frozen sample is transferred to an orange cassette labeled. 2FS for permanent processing.d 3. "Right renal mass deep margin" consists of 2 yellow-tan soft tissue fragments measuring 0.5 x 0.3 x 0.1 cm and 0.7 x 0.2 x 0.1 cm. They are entirely submitted in a white cassette labeled. :. #3 for permanent processing.. "Right kidney mass" is a partial nephrectomy specimen measuring 6.5 x 4.8 x 4.5 cm. There is a shiny. 4.  surface consistent with serosa measuring 5.1 x 4.5 cm on one side, fat below and kidney parenchyma on surface. Per surgeon, L  the area between the fat and the kidney parenchyna separated in the  trochanter bag revealing the pseudocapsule. There was also a small nick measuring up to 0.3 cm on the surface.  The specimen is inked In black. The black ink came In contact with the pseudocapsule which was repainted in green. The specimen is bisected revealing a nodule with yellow hemorrhagic cut. surface and with hard and soft areas. The nodule measures 4.6 x 1.3 x 4.1 cm. The tumor is at 0.1 cm from the closest surgicat margin. About 30% of the tissue is procured for Pictures are taken. In Surgical Pathology. the specimen received matches the above description. The specimen is serlally. sectoned. The tumor with pseudocapsule is submitted in white cassette' for permanent Patient Identification Surgical Pathology Report File in Page 3 of 4
+
+--- Page 4 ---
+Surgical Pathology Report MEDICAL RECORD Accession No.: Name: Date of Report: MrN: . processing. Another seven representative sectlons are submitted in white cassettes iabeled  48-4l for permanent processing. The procurement was performed by Gross description dictated by  No consuitants Surgical Pathology Report  Patient Identification File in Page 4 ot 4
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diff --git a/output/text/5022c4d8-0252-4611-bf7f-e7b53f985cb8.txt b/output/text/5022c4d8-0252-4611-bf7f-e7b53f985cb8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7d6d1d5c9e27f9e8d4a4de8f48c1537a2902ce4f
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+1cb-O-3 Carcoma,hfilt^otng duct, Nos 85oof3 Site Wd: breaot, nOs C 50.9 TSS Pt ID: 1o/s9/10 li SPECIMENS: UUID:E8A61AAC-BFF5-4341-B051-EDD87515ECDC A. SENTINEL LYMPH NODE #1 TCGA-E2-A10C-01A-PR Redacted B. SENTINEL LYMPH NODE #2 LEFT AXILLA C. SENTINEL LYMPH NODE #3 LEFT AXILLA D. SENTINEL LYMPH NODE #4 LEFT AXILLA E. SENTINEL LYMPH NODE #5 LEFT AXILLA F. WLE LEFT BREAST G. AXILLARY CONTENTS SPECIMEN(S): A. SENTINEL LYMPH NODE #1 B. SENTINEL LYMPH NODE #2 LEFT AXiLLA C. SENTINEL LYMPH NODE #3 LEFT AXILLA D. SENTINEL LYMPH NODE #4 LEFT AXILLA E. SENTINEL LYMPH NODE #5 LEFT AXILLA F. WLE LEFT BREAST G. AXILLARY CONTENTS INTRAOPERATIVE CONSULTATION DIAGNOSIS: TPA (microscopic): Lymph node, sentinel #1, biopsy: Negative for carcinoma. By called to Dr. at. TPB/C (microscopic): Lymph nodes, sentinels #2-3, biopsy: Negative for carcinoma. By Dr., called to Dr. at (B) and C). TPD (microscopic): Lymph node, sentinel #4, biopsy: Positive for carcinoma. By Dr., called to Dr. at .D) Gross Exam F Breast, left, wide local excision: Tumor mass is 0.6 cm from the anterior/inferior. margins. By Dr, called to Dr GROSS DESCRIPTION: A. SENTINEL LYMPH NODE #1 Received fresh is a tan-pink fragment of fibrofatty tissue 3.5 x 2.4 x 0.8 cm. Dissection reveals one presumptive lymph node 1.0 x 0.7 x 0.4 cm. The specimen is serially sectioned and touch preps are taken. The specimen is submitted entirely in cassette A1. B. SENTINEL LYMPH NODE #2 LEFT AXILLA Received fresh is a tan-pink lymph node 1.0 x 1.0 x 0.7 cm. The specimen is serially sectioned. Touch. preps are taken and the specimen is submitted entirely in cassette B1.. C. SENTINEL LYMPH NODE #3 LEFT AXILLA Received fresh is a tan-pink lymph node 1.0 x 1.0 x 0.7 cm. The specimen is serially sectioned. Touch. preps are taken and the specimen is submitted entirely in cassette C1.. D. SENTINEL LYMPH NODE #4 LEFT AXILLA Received fresh is a tan-pink lymph node 1.5 x 1.0 x 0.7 cm. The specimen is serially sectioned and. touch preps are taken. The specimen is submitted in toto in D1. E. SENTINEL LYMPH NODE #5 LEFT AXILLA Received in formalin is a tan-pink lymph node 2.0 x 1.0 x 1.0 cm. The specimen is serially sectioned and submitted in toto in cassette E1. F. WIDE LOCAL EXCISION LEFT`BREAST Received fresh is an oriented 57 gram wide local excision breast specimen measuring 8 x 6 x 4 cm. The specimen is inked as follows: anterior-blue, posterior-black, superior-red, inferior-orange, medial-. green, lateral-yellow. The specimen is serially sectioned from lateral to medial into six slices, slice 1 being most lateral and slice 6 being most medial, to reveal a gray-white, firm stellate mass measuring 2.2 x 2 x 2 cm located 0.6 cm from the closest anterior/inferior margin in slice 3, 4, 5 and 6. The remainder of the cut surfaces reveal predominantly yeilow lobulated adipose tissue interdispersed with. gray-white fibrous tissue. A portion of the specimen is submitted for tissue procurement. Representative sections are submitted as follows: A1: perpendicular sections of the lateral margin from superior to inferior, slice A2: anterior margins and area immediately adjacent to mass, slice 2 A3: anterior margin, slice 3 A4: inferior margin, slice 3
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+A5: deep margin, slice 3 A6: superior margin, slice 3. A7: mass with anterior and superior margins, slice 4. A8: mass with anterior and inferior margins, slice 4. A9-A10: mass with superior and deep margins bisected A11: mass with inferior and deep margins A12: mass with anterior margin, slice 5 A13: mass with inferior margin, slice 5. A14-A15: perpendicular sections of the mass with the medial margin from superior to inferior, slice 6 as per attached diagram G. LEFT AXILLARY CONTENTS Received in formalin are multiple tan-pink fragments of fibrofatty tissue aggregating to 9 x 6 x 3 cm. Dissection reveals nine possible lymph nodes ranging from 0.1 x 0.1 x 0.1 cm to 1.1 x 1.0 x 0.9 cm. Section code: G1: three possible lymph nodes G2: three possible lymph nodes. G3: two possible lymph nodes G4: one lymph node trisected G5: one lymph node trisected DIAGNOSIS: A. LYMPH NODE, SENTINEL #1, LEFT AXILLA, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1). B. LYMPH NODE, SENTINEL #2, LEFT AXILLA, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1) C. LYMPH NODE, SENTINEL #3, LEFT AXILLA, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1). D. LYMPH NODE, SENTINEL #4, LEFT AXILLA, BIOPSY: - METASTATIC CARCINOMA TO ONE OF ONE LYMPH NODE (1/1),  MEASURING O.6-CM WITH EXTERANODAL EXTENSION. E. LYMPH NODE, SENTINEL #5, LEFT AXILLA, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (O/1) F. BREAST, LEFT.WIDE LOCAL EXCISION: - INVASIVE, DUCTAL CARCINOMA, SBR GRADE-3, MEASURING 2.2-CM -^SURGICAL RESECTION MARGINS NEGATIVE FOR TUMOR - INTERMEDIATE NUCLEAR GRADE, DUCTAL CARCINOMA IN SITU WITH CENTRAL NECROSIS, CRIBRIFORM AND SOLID TYPES - SEE SYNOPTIC REPORT G. LYMPH NODES, LEFT AXILLARY CONTENTS, RESECTION: - EIGHT LYMPH NODES, NEGATIVE FOR METASTASES (0/8). SYNOPTIC REPORT - BREAST Excision Specimen Type:. Needle Localization: No Laterality:(Left Invasive tumor:" Present Multifocality: No WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Tumor size: 2.2cm Tumor site:  Not specified Margins: Negative Distance from closest margin:  0.5cm anterior/medial
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+Tubular score: 2 Nuclear grade: 3 Mitotic score:3 Modified Scarff Bloom Richardson Grade: Necrosis: Absent Vascular/Lymphatic Invasion: None identified. Lobular neoplasia: None Lymph nodes: Sentinel lymph node and axillary dissection Lymph node status: Positive 1 / 13 Extranodal extension DCIS present Margins uninvolved by DCIS: DCIS Quantity: Estimate 5% DCIS type: Solid Cribriform DCIS location: Associated with invasive tumor Nuclear grade: Intermediate Necrosis: Absent ER/PR/HER2 Results ER: Positive PR: Positive HER2: Negative by IHC Pathological staging (pTN): pT 2 N 1a SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimen: Surgical Excision Block Number: F12 ER: Positive Allred Score: 8 = Proportion score: 5 + Intensity Score 3 PR: Positive Allred Score: 6 = Proportion Score 3 + Intensity Score 3 COMMENT: The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring range from 0 to 8. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2. Methodology: Fixation Type and Length: Tissue was fixed in 10% neutral buffered formalin (.  for no less than 8 and no longer than 24 hours. Antibody and Assay Methodology:. Mouse anti-human ER and PR, Comment: This assay can be usea to select invasive breast cancer patients for hormone therapy (1). ER and PR analysis was performed on this case by immunohistochemistry utilizing the ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) antibody provided by  following the manufacturer's instructions listed in the package insert. This assay was not modified, and adherence to all instruction and guidelines were strictly followed. Interpretation of the ER/PR immunohistochemical staining. characteristics is guided by published results in the medical literature (1), information provided bv the reagent manufacturer and by internal review of staining performance within the . 1. Harvey JM, et al. Estrogen receptor status by immunohistochemistry is superior to the ligand-binding assay for predicting response to adjuvant endocrine therapy in breast cancer. J Clin Oncoi. 17:1474- 1481, 1999 SYNOPTIC REPORT - BREAST HER-2 RESULTS HER2 Status Results, Immunohistochemistry Evaluation. Specimen: Surgical Excision Block Number: F12
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+ NEGATIVE Interpretation: Intensity: 1+ % Tumor Staining: 5% Fish Ordered: No METHODOLOGY Methodology: Fixation Type and Length: Tissue was fixed in 10% neutral buffered formalin Inc. ) for no less than 8 and no longer than 24 hours. Antibodv and Assay Methodology:. Rabbit anti-human HER2, HerceptestTM (FDA-approved test kit), Control Slides Examined: External kit-slides provided by manufacturer (cell lines with high, low and negative HER2 protein expression), and in-house known HER2 amplified control tissue were evaluated along with the test tissue. These control slides run along side of this patient's sample showed appropriate staining. Adequacy of Specimen: Adequate, well preserved, clear-cut invasive carcinoma identified for HER2 evaluation. Scoring Criterion and Scoring System:. IHC Level of Expression(Score) /Tumor Cell Membrane Staining Pattern. Negative (0)/Absence of Staining Negative (1+)/Faint Incomplete membrane Staining, >10% of Cells Equivocal (2+)/Weak complete membrane Staining, >10% of Cells Positive (3+)/Strong complete membrane Staining, >10% of Cells Equivocal Category for HER2 IHC results: A HER2, 2+ staining result that is interpreted as equivocal may not indicate gene amplification. A FISH test for HER2 gene amplification will be ordered for all HER2 IHC 2+ results. COMMENT This assay can be used to select invasive breast cancer patients for Trastuzumab (Hereptin) therapy (1,2). Clinical Trials have shown that Trastuzumab substantially increases the likelihood for an objective response and overall survival for patients with metastatic HER2-positive breast cancer, regardless of whether HER2 tumor status was determined as IHC 3+ or FISH positive. Trastuzumab added to adjuvant chemotherapy substantially increase disease-free survival and decreases the risk of disease recurrence by about 50% for patients with early-stage HER2 protein over-expressed or gene amplified invasive breast cancer (3). HER2 analysis was performed on this case by immunohistochemistry utilizing the FDA approved HercepTest (Tm) test kit following the manufacturer's instructions listed in the package insert. This assay was not modified, and adherence to all instruction and guidelines were strictly followed. Interpretation of the HER2 immunohistochemical staining characteristics is guided by published results in the medical literature (4), information provided by the reagent manufacturer and by internal review of staining performance within the Pathology Department. HER2 TEST VALIDATION This HER2 immunohistochemical assay has been validated according to the recently revised recommendations and guidelines from the NCCN HER2 testing in Breast Cancer Task Force, and the jointly issued recommendations and guidelines from ASCO and the CAP (5). 80 randomly selected breast cancer samples were tested for HER2 by IHC as outline above and interpreted as, negative (score 0/1+) equivocal (score 2+) and positive (score 3+) without knowledge of the previous reported results. These cases were also blindly read using two different FISH assay as amplified or non-amplified and the HER2/CEP17 ratios were recorded. After analyzing these results, there was 100% concordance between the IHC and FiSH results for cases that were interpreted as either positive or negative by IHC. 9 of the 80 cases were interpreted as equivocal by IHC and of these 3/9 (33%) were non-amplified by FISH and 6/9 (66%) were found to be amplified. The Pathology Department Immunohistochemistry laboratory takes full responsibility for this tests performance and has programs in place to regularly monitor the proficiency and the interpretation of HER2 assays. The laboratory also participates in external quality assurance HER2 programs including the CAP proficiency testing program.. REFERENCE 1. Carlson RW, Anderson BO, Burstein HJ, et al., NCCN breast cancer clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2005;3:238-289. 2. Carlson RW, Brown E, Burstein HJ, et ai., NCCN Task Force Report: adjuvant therapy for breast cancer. J Natl Compr Canc Netw. 2006;4:S1-S26. 3. Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Eng J Med 2005;353(16):1673-84 4. Leong ASy, Formby M, Haffajee Z, et al. Refinement of immunohistologic parameters for Her2/neu scoring validation by FISH and CISH. Appl Immunohistochem Mol Morphol. 2006;14:384-389.
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+5. Wolff AC, Hammond EH, Schwartz JN, et al., American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Human Epidermal Growth Factor Recepto 2 Testing in Breast Cancer. Arch of Path and Lab Med 2007; 131:18-43. CLINICAL HISTORY: None provided PRE-OPERATIVE DIAGNOSIS: Left breast cancer Gross Dictation.., Pathologist, . Microscopic/Diagnostic Dictation: Pathologist, Microscopic/Diagnostic Dictation: Pathologist, Microscopic/Diagnostic Dictation:, Pathoioaist.. Final Review:.., Pathologist Final: Pathologist
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diff --git a/output/text/5035f64c-bf16-4a44-8e26-600ef3ac6548.txt b/output/text/5035f64c-bf16-4a44-8e26-600ef3ac6548.txt
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+UUID:1659798C-9B6A-4DF9-A586-79AD2194DF11 TCGA-GM-A3NY-01A-PR Redacted lw 1/nJ13 DIAGNOSIS (A) LEFT BREAST, SEGMENTAL MASTECTOMY: INVASIVE LOBULAR CARCINOMA, CLASSICAL TYPE, MODIFIED BLACK'S NUCLEAR GRADES 1 AND 2. INVASIVE CARCINOMA COVERS AN AREA OF APPROXIMATELY 3 CM.. INVASIVE CARCINOMA EXTENDS TO WITHIN 3.0 MM OF DEEP, 3.0 MM OF INFERIOR AND 5.0 MM OF SUPERFICIAL MARGINS. LYMPHOVASCULAR INVASION IDENTIFIED. LOBULAR CARCINOMA IN SITU. Intraductal papilloma. Fibrocystic changes including duct epithelial hyperplasia without atypia, apocrine metaplasia, radial scar and cyst. Microcalcifications present and associated with fibrocystic changes. (B) LEFT BREAST CAPSULE, CAPSULECTOMY: Dense fibrous connective tissue, no tumor present. (C) LEFT BREAST, NEW SUPERFICIAL INFERIOR MARGIN, EXCISION: Breast parenchyma with fibrocystic changes including florid ductal hyperplasia without atypia, apocrine metaplasia and microcysts. No evidence of malignancy. (D) LEFT BREAST, ADDITIONAL SUPERFICIAL MARGIN, EXCISION:  Skin and subcutaneous adipose tissue, no evidence of malignancy.. (E) LEFT AXILLA, LEVEL 1 AND 2 LYMPH NODES, EXCISION: METASTATIC CARCINOMA IN ONE OF TWELVE LYMPH NODES. METASTATIC CARCINOMA MEASURES 2.8 CM IN GREATEST DIMENSION. EXTRANODAL EXTENSION UP TO 3.0 MM PRESENT. (F) LEFT AXILLARY LEVEL 3 LYMPH NODE: 1es-0-3 One lymph node, no tumor present.. 1cbulw, No5 8ssoj3 c arcinona, mfiitret,vg Sife: brcot Nos c50.9 GROSS DESCRIPTION (A) LEFT SEGMENTAL MASTECTOMY, SHORT SUPERIOR, LONG LATERAL, PURPLE INK DEEP - One pale-yellow segmental mastectomy specimen (9.5 x 8.0 x 4.2 cm) with a short stitch to mark the superior, long stitch to mark lateral and purple ink to mark the deep. The specimen is inked, serially sectioned from medial to lateral into twelve slices. Located at slice 3 through slice 8, there is one pale-gray, firm, ill-defined nodule (3.2 x 21.8 x 2.7 cm) is identified, located at 0.2 cm from deep margin, 0.2 cm from the anterior margin, 0.2 cm from superior margin, 1.2 cm from inferior margin, 0.6 cm from medial margin and 2.2 cm from lateral margin. One clip is identified at slice 5, central portion. A portion of normal tissue and tumor is submitted for tumor bank. INK CoDE: Blue - superior; green - inferior; yellow - superficial; black - deep; red - lateral and medial. SECTiON CODE: A1, slice 1, entirely submitted of the slice, perpendicular for medial margin; A2, slice 12, central portion. lateral margin perpendicular; A3, slice 2, central portion with deep margin section adjacent to the lesion at slice 3; A4, slice 3, central portion nodule with anterior margin; A5, slice 3, central portion nodule with deep margin; A6, slice 3, central to inferior portion with the anterior margin; A7, slice 3 central to inferior portion tumor with the deep margin; A8-A14, entirely submitted of the slice 4 from superior to inferior direction; A15-A20, entirely submitted of the slice 5 from superior to inferior direction (A16 associated with clip); A21-A28, slice 6, entirely submitted of the slice submitted from superior to inferior direction; A29, slice 7, inferior portion with inferior and deep margin; A30, slice 8, superior portion with the superior margin; A31, A32, slice 8, central portion nodule with the deep nodule submitted from superior to inferior direction; A33, slice 9, central portion section adjacent to the lesion at slice 8. *GROSS EVALUATION: TUMOR EXTENDS SUPERFICIAL/SUPERIOR AND DEEP MARGINS. (B) LEFT BREAST IMPLANT AND PARTIAL CAPSULECTOMY - An 11.5 x 11.5 x 2.5 cm tan-yellow plastic breast implant devoid of contents. There is a 7.0 x 2.5 x 1.0 cm irregular piece of tan-yellow fibroadipose tissue attached to the surface of the breast implant. No inscriptions are noted. Representative sections of the fibroadipose tissue is submitted in B1-B2. Photos are also taken. (C) NEW SUPERFICIAL INFERIOR MARGIN, INK MARKS TRUE MARGIN - One pale-yel|low fibroadipose tissue (4.5 x 1.8 x 0.6 cm) with one side inked with purple to mark the true margin. The true margin is reinked and the specimen is serially sectioned and entirely submitted. INK CODE: Blue - true margin..
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+SECTiON CODE: C1-C4, entirely submitted of the specimen. (D) ADDITIONAL SUPERFICIAL MARGIN, INK ON TRUE MARGIN - One pale-yellow fibroadipose tissue (2.5 x 1.6 x 0.6 cm) with purple ink to mark the true margin. The true margin is inked and the specimen is serially sectioned and entirely submitted. Aiso in the container, there are two unremarkable pale-gray skin strips (5.2 x 0.5 x 0.5 cm, 3.6 x 0.4 x 0.6 cm, respectively). The resection margin of the skin is inked and specimen is serially sectioned and entirely submitted.. INK CODE: Blue - resection margin. SECTION CODE: D1, entirely submitted of the fibroadipose tissue; D2, D3, each containing one piece of skin strip.. (E) LEFT AXILLARY, LEVEL 1 AND 2 LYMPH NODES - An 11.0 x 7.5 x 2.5 cm portion of yellow fibroadipose tissue which yields multiple possible lymph nodes ranging from 0.5 cm to 4.0 x 3.2 x 1.5 cm. The largest lymph node has a solid tan-white lobulated cut surface suggestive of metastases. The lymph nodes are submitted entirely.. SECTiON CODE: E1-E4, one lymph node bisected in each cassette; E5, two lymph nodes; E6, four lymph nodes; E7, largest lymph node. (F) LEFT AXILLARY LEVEL 3 LYMPH NODE - A 3.0 x 2.5 x 0.8 cm portion of yellow fibroadipose tissue which yields two possible lymph nodes, both measuring 1.0 cm in greatest dimension. The lymph nodes are submitted entirely in F. CLINICAL HISTORY None given. SNOMED CODES T-04050, M-85203, T-C4710, M-85206 "Some tests reported here may have been developed and performance characteristics determined by . These tests have not been specifically cleared or approved by the U.S. Food and Drug Administration." Entire report and diagnosis completed by:. Start of ADDENDUM
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+This report is issued to give Immunohistochemistry results. Immunohistochemical staining is performed on a representative Pen. Fixed, paraffin-embedded section of METASTATIC CARCINOMA, axillary lymph node, block E7. MARKER Clone/Vendor RESULTS STAINING SCORE HER2 overexpression AB8 (NeoMarkers) Negative 0 FOoTNOTE Breast specimens used for determining prognostic / predictive markers are fixed in either formalin or Pen-Fix (buffered alcoholic formalin fixative) for 6 - 48 hours. For ER & PR:  Positive 10 - 100% 1-9% Low Positive For Ki-67 Low Positive <17% Intermediate Positive 17-35% High Positive >35% Entire report and diagnosis completed by: .--end Of report--
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diff --git a/output/text/5044ac9a-6f26-4219-b97c-64f8fde2ac5e.txt b/output/text/5044ac9a-6f26-4219-b97c-64f8fde2ac5e.txt
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+CGA-AL-3472 SURGICAL PATHOLOGY REPORT Clinical History/Diagnosis: Left renal mass Source of Specimen(s): 1: 2 Portions of 11th Rib 2: Mass Left Renal 3: Base of Mass 4: Base of Mass Gross Description: Received in four parts. Source of tissue: 1. Labeled #1, "two portions 11th rib' Gross description: Received fresh labeled ". two portions 11th rib" consists of two portions of pink-red bone with minimal attached soft tissue 1.2 x 1.1 x 0.3 cm and 2.5 x 1 x 0.4 cm. Entirely submitted in cassette 1A following fixation and decalcification kk***************************************************** Source of tissue: 2. Labeled #2, "left renal mass" Frozen Section Diagnosis: 2FS RENAL CELL NEOPLASM FAVOR PAPILLARY TYPE. MARGIN IS NEGATIVE PER Gross description: Received fresh for frozen section labeled ", left renal mass" consists of a 448 gram, 11 x 9 x 6.5 cm yellow-pink encapsulated mass. The specimen comes designated with. a clip at the base. The base is inked black and the area of the clip is frozen for frozen section diagnosis. Further sectioning reveals yellow,. possibly necrotic cut surfaces. A piece of the specimen is sent to. Cytogenetics, and pictures are taken per surgeon. Representative sections are submitted as designated for microscopic evaluation.. Designation of sections: 2FS frozen section. 2A tumor in relation to normal. 2B-2E random sections all in relation to capsule. Please note that cassette 2E contains sections in relation to base.. ****************************************************** Source of tissue: 3. Labeled #3, "base of mass". Frozen Section Diagnosis: 3FS NO TUMOR SEEN Gross description: Received fresh for frozen section labeled , base of mass" consists of 0.5 x 0.4 x 0.2 cm fragment of pink-tan soft tissue. Entirely frozen and submitted in cassette 3FS for. microscopic evaluation. ****************************** ************************* Source of tissue: 4. Labeled #4, "lateral base of mass". Frozen Section Diagnosis: 4FS NO TUMOR SEEN Gross description: Received fresh for frozen section labeled , lateral base of mass". consists of one irregular
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+fragment of tan soft tissue 0.5 x 0.3 x 0.2 cm. Entirely frozen and. submitted in cassette 4FS for microscopic evaluation.. All specimens are placed in formalin at. ************************* Final Diagnosis: 1. Two portions, 11th rib" - No tumor seen. 2. Left renal mass: - Renal cell cacinoma, papillary type (11.0 cm) type I. - Angiolymphatic invasion is not identified.. - Resection margin free of tumor.. 3. Base of mass: - No tumor seen. 4. Lateral base of mass:. - No tumor seen. pT2 No Mx Procedures/Addenda FC Cytogenetics Solid Results-Comments CYTOGENETIC ANALYSIS REPORTS DIAGNOSIS: Papillary Renal Cell Carcinoma KARYOTYPE: Abnormal karyotype: 47,X,+7,+17[20] RESULTS: The renal mass was-harvested after three and four days in culture. The chromosomes from twenty metaphases were counted and. analyzed, and three of these metaphases were karyotyped by G-banding. The. modal chromosome number was 47, and the cells were missing. chromosome and contained an extra copy of chromosomes 7 and 17. Loss of and trisomy for chromosomes 7 and 17 have been reported in cases of. papillary renal cell carcinoma and are consistent with this patient' s. diagnosis.
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diff --git a/output/text/510227e6-118f-498d-a27a-245229e86b45.txt b/output/text/510227e6-118f-498d-a27a-245229e86b45.txt
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index 0000000000000000000000000000000000000000..6d9e219266e50a69da287aa52a9a5dcdfc9e4945
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+/CL-0 -3 adenrcaciiomb, mvcinns, Nos 8y86f3 Sife : cecum c18.0 3/29/1 Sample ID #: Diagnosis: Hleocolonic resectate under inclusion of a poorly differentiated mucinous adenocarcinoma of the colorectal type, located in the cecum/ascending colon and of max. 7.5 cm in. diameter, with circumscribed penetration of the serosa. Tumor-free regional lymph. nodes. Tumor-free small and large intestinal resection margins. Tumor-free mesenteric resection margin. Tumor-free omental fat tissue.. Tumor stage: pT4 pN0 (0/20) pMX; G3; L1, V0, locally R0 A further lymph node is still being decalcified; a follow-up report will be submitted at a later date. Follow-up report:. We now have the histological data on the decalcified lymph node. In this case, there is also no indication of metastasis from the previously diagnosed carcinoma. Final tumor stage therefore pT4 pN0 (0/21) pMX; G3; L1, V0, locally R0 UUID:8A14A987-711E-49C Redacted
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diff --git a/output/text/514554ca-6b84-45c5-8190-5476d6c422e8.txt b/output/text/514554ca-6b84-45c5-8190-5476d6c422e8.txt
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index 0000000000000000000000000000000000000000..5506e506b693fae3c64ec66c74c0b0011289f532
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+UUID:D7E1CBFA-6E00-48AF-804D LCA65506 TCGA-DK-A6B6-01A-PR Redacted SURGICAL PATHOLOGY REPORT Patient Name: Accession #: Med. Rec. #: Date of Procedure: DOB: (Age: Location: Date of Receipt: Gender: Service:  Urology Date of Report: Ref. Physician: Patient Address: Account #: Billing Type: OUTPATIENT Additional Copy to: Ref. Source Clinical Diagnosis & History: T1 HG no muscle on prior biopsy. Specimens Submitted: 1: Right posterior bladder wall tumor, TURBT DIAGNOSIS: LBD-0 -3 1. Right posterior bladder wall tumor, TURBT: Part# 1 8/20/3 Tumor Type: Invasive urothelial carcinoma, NOS Histologic Grade: C674 wail  High grade ) 4/18[13 Pattern of growth of the non-invasive component:  Papillary and flat Local Invasion: Muscularis propria Vascular Invasion: Not identified Non-Neoplastic Mucosa: Exhibiting proliferative cystitis (Brunn's nests, cystitis cystica, cystitis glandularis) I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL). AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. *** Report Electronically Signed Out. Gross Description: 1.) The specimen is received in hank's solution, labelled " Right posterior bladder wall tumor " and consists of multiple piece(s) of irregular tan-brown soft tissue fragments measuring 1.1 x 1.0 x 0.7 cm in aggregate. The specimen is entirely submitted in two cassettes. Some tissue was taken by T P S. Summary of Sections: Block Sect. Site PCs Page 1 of 2
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+SURGICAL PATHOLOGY REPORT {not entered} 12 2 575/17 Page 2 of 2 END OF REPORT
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+
+--- Page 1 ---
+ UUID: B8676218-180D-432D-A821-CDA5947838FE TCGA-L5-A43M-01A-PR Redacted PREVIOUS DIAGNOSIS INQUIRY PAGE #: 2 PATIENT NBR: SEX: PAT TYPE: Comments: AcCESSION: OPER DATE: 1 REQ DOC: PROCEDURE: SPHS VERIFIED BY: Source of specimen: Distal esophagus, proximal stomach. History of a t2N0 distal esophagus cancer, pancreatic 2.3 cm tesion. History of colon cancer, hypertension, osteoarthritis, glaucoma bilateratly, left central retinat vein occlusion, hysterectomy, open chole, sigmoid colon and resection, cance. and dysphagia. PROCEDURE: SPGD VERIFIED BY: 1. "Distal esophagus proximal stomach" Received in formalin in a large. container is a 6.2 cm tong portion of distal esophagus and an 11 x 3.5 x 1.1 cm proximal cuff of stomach. The adventitia is. red-tan and unremarkable. The esophageal mucosa is gray-tan and predominantly folded. At the. gastroesophageal gastric junction a focal area of granular tissue is identitied. Underlying the esophagogastric junction an ill-detined 7.2 x 1.3 x 0.3 cm annular tumor is identified at the cardia of the stomach. There is possible some extension into the esophagus. The tunor is 5.5 cm away trom the proximal margin and 1.8 cm away fron the distal margin, tan-gray and granular. The distal margin is inked blue, the adventitia is inked black. Tunor has a maximun depth of 0.7 cm and extends to paraesophageal fat. Multiple possible lymph nodes are identified ranging up to 1.2 cm.. 1A. Proximal margin, shave and submitted for frozen section. Frozen section control. 18-c. Distal margin, representative sections. Frozen section control. 10. Tumor to distal margin. 1e. Tumor to esophagogastric junction and adjacent proximal tissue. 1F-G. Tumor to deep. 1H. Tumor to esophagogastric junction.. 11. Multiple possible lymph nodes. 1J-M. One bisected lymph node.( 2. "New proximal margin, cervical. esophageal margin" Received in formalin in a small container is a 1.2 cm long x 2.2 cm in diameter portion of esophagus. Submucosal hemorrhage is identified. No other abnormalities are noted. FROZEN SECTION REPORT 1cD-o-3 1A. Proximal margin negative. Q denocarcinomq, no S 18-c. Distal margin negative. 81+0/3 Sikics0phaqus,di stg 1Hh;rd C/5.5 8'z0-iZ ri7
+
+--- Page 2 ---
+PREVIOUS DIAGNOSIS INQUIRY PAGE #: SEX: PAT TYPE: ACCESSION: OPER DATE:  have reviewed and interpreted the frozen section. material at the time it was requested. Permanent sections confirm frozen section report.. PROCEDURE: SPMI VERIFIED BY: ESOPHAGUS CARCINOMA LOCATION: Lower size: 7.2 cm TREATED wITH ChEmO/RADIATION THERAPY:E No TYPE OF CARCINOMA: Adenocarcinoma DEPTH OF INVASION: Superficially into periesophageal adipose. NUMBER. OF POSITIVE LYMPH NODES / TOTAL NUMBER OF NODES EXAMINED: 4/8 DISTANT METASTASIS: Unknown RESECTION MARGIN INVOLVED: No T3 N2 PROCEOURE: SPDX VERIFIED BY: 1. Distal esophagus and proximal stomach, distal esophagectony: Adenocarcinona (7.2 cm), invading inta adventitia/periesophageal adipose. Margins negative. Four of eight lymph nodes positive for metastatic adenocarcinoma. Please see template for details. 2. New cervical esophageal margin, excision: Negative for carcinoma.. Pathologic tindings discussed with. I the signing staff pathologist, have personally. Site ogoreruL by Tc6A s/9fis. rior Malgr ual/Sync is (circ
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diff --git a/output/text/515ab7e3-743d-4779-a5f5-4a0c6e44132a.txt b/output/text/515ab7e3-743d-4779-a5f5-4a0c6e44132a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7420cb487e6fb0bf64cc8e42bff07fad5d47f1ff
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+AL DIAGNOSIS Ney, Left, nephrectomy .  RENal CELl CarcinomA, ConvenTIonal (CLeaR CELl) Type with EXTensive myXoId Changes. A. B.  FUHRMAN NUCLEAR GRADE IS III OF IV. The greatest Diameter of the neoplasm Is 3.8 cm.  THE NEOPLASM IS CONFINED WITHIN THE RENAL CAPSULE. D E.  NO iNVASION OF THE RENAL VEiN IS IDENTIFIeD. F. NO EVIDENCE OF ANGIOLYMPHATIC INVASION IS IDENTIFIED. G. ALL SURGICAL MARGINS ARE FREE OF THE NEOPLASM. H.  THe nOn-nEOpLAsTiC ADJAcent KIdney ShOWs fEaTures DuE tO proxImity The TumOR TNM STAGE: pT1a NX MX.
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diff --git a/output/text/515cb229-0af7-46a7-829f-157904c907ca.txt b/output/text/515cb229-0af7-46a7-829f-157904c907ca.txt
new file mode 100644
index 0000000000000000000000000000000000000000..93569377379569ce6f450ec3cb28187606e1baa5
--- /dev/null
+++ b/output/text/515cb229-0af7-46a7-829f-157904c907ca.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+F5E13F-7B32-4D60-BD15-A50AC112DBEB TCGA-UD-AAC7-01A-PR Redacted Page 1 ot I Pathology Report Printed Ref. by . DOB: Sex: M Collection Date: CLINICAL HISTORY: Pleural effusion and blood ? meso.. MACROSCOPIC: Lung biopsy: Six tan fragments ranging from 2-5mm (1x6ae, ). MICROSCOPIC: Sections show a fragment of an infiltrating epithelioid neoplasm. The. tumour cells do not produce mucin but some tissue mucin is present. A panel of antibodies shows the following profile;. Keratin broad spectrum (AEl/3); Calretinin and wT-1 all positive. TTF-1 and cEA (polyclonal): both negative.. CONCLUSION: Lung biopsy;  MALIGNANT MESOTHELIOMA, epithelioid. Pathologist: zaD-6-3 Mostbelieyne sjoithele Site: YwaNbS C38.4 39 Confidontiality: This document is confidential. If you are not the Intended recipient you must not read, copy, distribute or act in reliance on it. If you have recleved this document in error please notify us immediately and destroy the original message.. ual/Syr CUALIED
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diff --git a/output/text/516cca71-03f9-482e-9f3c-329a9e4dea7b.txt b/output/text/516cca71-03f9-482e-9f3c-329a9e4dea7b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a2c43ae0eeb389cb59deec03a1738548261e227b
--- /dev/null
+++ b/output/text/516cca71-03f9-482e-9f3c-329a9e4dea7b.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+1cb-0-3 Carcmomn,vifitt^atNg1obulw x5dvJ3 Site: buast, Nos C5s.9 1/27/n h Name: Age/Sex: /F Location: Acct#: Onit#: Status: DIS IN Room/Bed: Reg: Disch: Att Dr: Specimen: Received: Status: Req#: Spec Type:  SURGICAL P Subm Dr: HEOPA R KIAHCSIS LEFT BREAST CANCER INVASIVE DATE: DOCTOR(S) : PROCEDURE : BILATERAL SIMPLE MASTECTOMY-SENTINEL NODE BX o/1 A. LT SENTINEL NODE #2 FS LT SENTINEL NODE #1 % B. UUID: 377F7050-F900-4345-A326-568F000508C3 TCGA-A2-A0T6-01A-PR Redacted c. LT SIMPLE MASTECTOMY D. RT SIMPLE MASTECTOMY E. RT SENTINEL NODE #1O/ F. RT SENTINEL NODE #2 $. POSSIBLE LT SENTINEL NODE h. LT SENTINEL NODE #%E A A. BENIGN PART A  RECEIVED FRESH LABELED LEFT SECOND SENTINEL NODE PALPABLE, CONSISTS OF AN IRREGULAR PORTION C YELLOW-RED FATTY TISSUE MEASURING 2.5 X 1.0 X 1.0 CM. SECTIONING REVEALS 2 LYMPH NODES, THE LARGER O.9 CM IN DIAMETER DEMONSTRATES A RIBBON CLIP. THE SECOND IS 0.5 CM. SECTION OF THE LARGER IS SUBMITTED AS FSA. THE REMAINDER OF THES SPECIMEN IS SUBMITTED LABELED A. PART B RECEIVED FRESH LABELED LEFT FIRST SENTINEL NODE HOT AND BLUE, IS A PORTION OF YELLOW-RED FATTY TISSUE MEASURING 2.2 X 1.5 X 1.O CM. SECTIONING REVEALS GROSSLY UNREMARKABLE NODAL TISSUE WITH FOCAL BLUE DYE. ONE HALF IS SUBMITTED PER PROTOCOL, THE REMAINDER ISS SUBMITTED LABELED B. PART C  RECEIVED FRESH LABELED LEFT SIMPLE MASTECTOMY STITCH AT 12 O'CLOCK, IS A MASTECTOMY SPECIMEN WITH OVERALL DIMENSIONS OF 23.5 X 20.5 X 4.5 CM. THE NIPPLE IS UNREMARKABLE AND IS WITHIN AN IRREGULAR SHAPED SKIN EXCISION MEASURING 8.0 X 4.3 CM IN GREATESTS
+
+--- Page 2 ---
+Patient (Continued) Specimen: Received: Status: Req#: Spec Type: SURGICAL P Subm Dr: (Continued) DIMENSIONS. A SUTURE DENOTES 12 O'CLOCK AND BLUE DISCOLORATION IS NOTED IN THE UPPER INNER QUADRANT.  THE SUPERFICIAL ASPECT IS MARKED WITH BLUE INK, THE DEEP MARGIN IN BLACK INK.  SECTIONING REVEALS DENSE PINK-TAN FIBROUS NODULE IN THE MIDPORTION OF THE SPECIMEN WHICH IS CENTRAL AND IN THE SUPERIOR ONE-HALF OF THE SPECIMEN TO INCLUDE BOTH THE OUTER AND INNER QUADRANTS. IT HAS AN IRREGULAR SHAPE .WITH NO PERCEPTIBLE DIFFERENTIATION BETWEEN THE LOBULATED ARMS CREATING A 7.O CM SPAN FROM MEDIAL TO LATERAL 3.5 CM FROM SUPERIOR TO INFERIOR AND UP TO 2.5 CM FROM ANTERIOR TO POSTERIOR. THIS EXTENDS TO WITHIN O.7 CM OF THE DEEP MARGIN. THERE ARE SMALL PALPABLE NODULES SURROUNDING THIS. ONE OF THESE IN THE UPPER INNER QUADRANT MEASURES O.5 CM AND IS 1.3 CM FROM THE DEEP MARGIN. GROSSLY THIS IS NOT IN CONTINUATION WITH THE LESION AND SEPARATED BY 1 CM. THE PERIMETER TISSUE IS BLAND YELLOW FATTY TISSUE. SECTIONS ARE SUBMITTED AS FOLLOWS: C1--NIPPLE AND SKIN (MIRROR IMAGE TO PROTOCOL), C2--THE FAR MEDIAL PORTION OF THE LARGE LESION IN THE UPPER INNER QUADRANT, C3--THE SMALL NODULE IN THE UPPER INNER QUADRANT, C4--TISSUE FROM LOWER INNER QUADRANT 2 CM INFERIOR TO C2, C5 THROUGH C7--A SUPERIOR TO INFERIOR CROSS-SECTION OF THE LESION IMMEDIATELY SUBAREOLAR, C8--LESION AND DEEP MARGIN (MIRROR IMAGE TO PROTOCOL SECTION), C9 AND C1O--SECTIONS OF) PALPABLE LESION FAR LATERAL, SUPERIOR, AND INFERIOR, C11--LESION AND SUPERFICIAL MARGIN, C12--THE SUPERFICIAL PORTION OF THE LESION AND SKIN CORRESPONDING TO C8, C13--LOWER OUTER QUADRANT 3 CM FROM TUMOR, C14--UPPER OUTER QUADRANT 3 CM FROM TUMOR, C15--TUMOR (MIRROR IMAGE TO PROTOCOL). C16--TISSUE 6 O'CLOCK. PART D RECEIVED FRESH LABELED RIGHT SIMPLE MASTECTOMY STITCH AT 12 O'CLOCK, IS A SIMPLE MASTECTOMY SPECIMEN MEASURING 16.0 X 15.5 X 4.0 CM. THE NIPPLE IS UNREMARKABLE WITHIN A 7.2 X 4.3 CM SKIN ELLIPSE. A SUTURE DENOTES 12 O'CLOCK. THE SUPERFICIAL ASPECT IS MARKED WITH BLUE INK, THE DEEP WITH BLACK.  SECTIONING REVEALS A CENTRAL PORTION OF THE BREAST TO CONSIST OF PINK-TAN FIBROUS TISSUE WITH MULTIPLE FLUID-FILLED CYSTS.  THIS IS SURROUNDED BY A PERIMETER OF BLAND YELLOW FATTY TISSUE WITH FINE FIBROUS BANDS. THE FIBROUS COMPONENT IS SO% OF THE SPECIMEN. ONE CYST IN THE 9 O'CLOCK AREA CONTAINS TAN PUTTY-LIKE MATERIAL (D3). THE SPECIMENS ARE SUBMITTED AS FOLLOWS: D1--NIPPLE, D2--9 O'CLOCK AREA (MIRROR IMAGE TO PROTOCOL BLOCK), D3--CYST IN 9 O'CLOCK AREA, D4--LOWER OUTER QUADRANT, D5--UPPER OUTER QUADRANT, D6--CENTRAL DEEP MARGIN, D7 AND D8--LOWER INNER QUADRANT, D9 AND D10--UPPER INNER QUADRANT. PART E RECEIVED FRESH LABELED RIGHT SENTINEL NODE BLUE NOT HOT, IS FATTY TISSUE MEASURING 2.8 1.0 CM. SECTIONING REVEALS A O.8 CM IN DIAMETER RED-TAN NODE. HALF IS SUBMITTED FOR PROTOCOL, THE REMAINDER IS SUBMITTED LABELED E. PART F  RECEIVED FRESH LABELED SECOND RIGHT SENTINEL NODE
+
+--- Page 3 ---
+Patient: (Continued) Received: Status: Req# : Specimen: Spec Type: SURGICAL P Subm Dr: ! GOSS DESCRIPION (Continued) HOT BLUE, IS AN OVOID PORTION OF RED-TAN TISSUE MEASURING 2.5 X 1.3 X 1.0 CM, IS A 1.2 CM LYMPH NODE SHOWING BLUE DISCOLORATION. ONE-HALF IS SUBMITTED PER PROTOCOL, THE REMAINDER IS SUBMITTED LABELED F. LEFT FOURTH SENTINEL PART G RECEIVED FRESH LABELED NODE HOT ONLY, IS YELLOW FATTY TISSUE MEASURING 2.3 X 1.5 X 0.8 CM. IT REVEALED A 1 CM GROSSLY UNREMARKABLE LYMPH NODE. ONE HALF IS SUBMITTED PER PROTOCOL, THE REMAINDER IS SUBMITTED LABELED G. PART H RECEIVED FRESH LABELED  POSSIBLE LEFT SENTINEL NODE HOT NOT BLUE, YELLOW-FATTY TISSUE. THIS NODAL TISSUE IS IDENTIFIEDS AND THE SPECIMEN IS SUBMITTED ENTIRELY LABELED H. PROCEDURES: 88307/8, IMMUNOPEROXIDAS/6, PATH FS , ABX X6, BBX X6, C BLK/16, D BLK/1O, EBX X6, FBX X6, FROZ.SEC. A, GBX X6, HBX X6 PARTS A AND B LEFT SECOND AND FIRST AXILLARY SENTINEL LYMPH NODE BY NEGATIVE CYTOKERATIN IMMUNOHISTOCHEMICAL STAINING. Icm af ILe - mcethric PART C LEFT SIMPLE MASTECTOMY: MULTICENTRIC IN SITU AND INFILTRATING LOBULAR CARCINOMA. THE TUMOR IS NUCLEAR GRADE II/III WITH A LOW MITOTICS INDEX.  INVASIVE CARCINOMA SPANNED A GROSS DISTANCE OF 7.O CM FROM MEPIAL RpeRmi. TO LATERAL IN THE SUPERIOR CENTRAL PORTION OF THE SPECIMEN, SPANNING /THE THE SUPERFICIAL AND DEEP MARGINS ARE FREE OF TUMOR BY AT LEAST 1 CM. PART D  RIGHT SIMPLE MASTECTOMY:  FIBROCYSTIC CHANGES WITH FOCALLY MARKE NON-ATYPICAL INTRADUCTAL EPITHELIAL HYPERPLASIA PRESENT. NO EVIDENCE OFS F 1DH-a MALIGNANCY. PARTS E AND F RIGHT FIRST AND SECOND AXILLARY SENTINEL LYMPH NODE BIOPSIES: LYMPH NODES WITH NO EVIDENCE OF METASTATIC DISEASE, SUPPORTI BY NEGATIVE CYTOKERATIN IMMUNOHISTOCHEMISTRY.S PART G LEFT FOURTH AXILLARY SENTINEL LYMPH NODE, BIOPSY: LYMPH NODE WITH NO EVIDENCE OF METASTATIC DISEASE, SUPPORTED BY NEGATIVE CYTOKERATIN IMMUNOHISTOCHEMICAL STAINING.S
+
+--- Page 4 ---
+Patient: (Continued) Specimen: Received: Status: Req#: Spec Type: SURGICAL P Subm Dr: (Continued) PART H POSSIBLE LEFT AXILLARY LYMPH NODE, BIOPSY: ADIPOSE TISSUE WITH NO LYMPH NODE PRESENT. Signed (signature on file)
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diff --git a/output/text/51720691-1a61-4434-9455-1126edea0850.txt b/output/text/51720691-1a61-4434-9455-1126edea0850.txt
new file mode 100644
index 0000000000000000000000000000000000000000..681d69d8b91539521b93f2cf6f65cf4df94ccd24
--- /dev/null
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+
+--- Page 1 ---
+Surgical Pathology Report Name: Case #: DOB: Collected: Gender: Received: MRN: Reported: Location: Copy To: Physlcian: Pathologic Interpretation: A. Right breast mass, short stitch superior, long stitch lateral, double stitch deep: - Infiltrating ductal carcinoma, colloid type, low nuclear grade, 3.0 cm in greatest dimension. - Margins of excision are free of tumor. -pT2NOMX - See tumor summary. 8. Lateral margin right breast: /cs-0-3 - Breast tissue with adenosis. - New margin is negative for malignancy. Carcioma mifiltratry oluct!and mquciors 8573] Sit : bst, Nos. C50.9 3/s/u p C. Additional superior margin: - Breast tissue with no pathologic change. - New margin is negative for malignancy. D. Sentinal node # 1: - No malignancy seen in one lymph node (0/1). - Immunohistochemistry for keratin is negative for carcinoma.. E. Sentinel node # 2: - No malignancy seen in one lymph node (0/1). - Immunohistochemistry for keratin is negative for carcinoma.. F. Non sentinel node # 1:. - No malignancy seen in one lymph node (0/1). UUID:4C403309-3178-4E7E-A987-47698E5E3648 G. Non sentinel node # 2: TCGA-EW-A10X-01A-PR Redacted - No malignancy seen in one lymph node (0/1) H. Axillary tissue: - Fibroadipose tissue, no malignancy seen. - No lymphoid tissue present.. Tumor Summary: Specimen Type: Excision Lymph Node Sampling: Sentinel lymph node(s) only Specimen Size (for excisions less than total mastectomy): 9 x 7.5 x 3.5 cm Laterallty: Right. Size of invasive Component: Greatest dimension: 3.0 cm *Additional dimensions: 2.4 x 2.4 cm Histologic Type: Invasive ductal carcinoma Mucinous Histologic Grade (any grading system may be used; mitotic count is also required independent of the grading system): Tubule Formation: Majority of tumor greater than 75% (score =1)  Nuciear Pleomorphism (Small regular nuclei (score =1) Mitotic Count: Less than 10 mitoses per 10 HPF (score =1) Total Nottingham Score: Grade I: 3-5 points Pathologic Staging: Primary Tumor: pT2 Regional Lymph Nodes: pNO - Specify: Number examined: 4 Number involved: 0 Distant Metastasis: pMX Margins: Uninvoived by invasive carcinoma
+
+--- Page 2 ---
+SURGICAL PATHOL Report Venous/tymphatic (Large/Small Vessei) Invasion (V/L): Absent ER: Positive  pr: Positive ( HER2: Negative( 1D5=FR Pgl 636PR A48s HER2, H-11=EGiFR Ail immwnohistochemial sains are nxd wih formolin of molecuior fixed poroffin embedikd nine. Deection x by Envison Method. T wis we reod hy a potholngist a positive or ngative. As the atending pathologist, I attest that I: (i) Examined the relevdnt preparation(s) for the specimen(s): and (ii) Rendered the diagnosis(es). . mD . MD ***Electronically Signed Out By*** Intraoperative Consultation B. Lateral margin right breast, FS: No malignancy seen. D. Sentinal node # 1, FS: Negative for tumor. E. Sentinel node # 2, FS: Negative for tumor. F. Non sentinel node # 1, FS: Negative for tumor. G. Non sentinel node # 2, FS: Negative for tumor. MD Clinical History: {Not Provided} Specimen(s) Received: A: Right breast mass, short stitch superior, long stitch laterai, double stitch deep B: Lateral margin right breast, FS C: Additional superior margin D: Sentinal node # 1, FS E: Sentinel node # 2, FS F: Non sentinel node # 1, FS G: Non sentinel node # 2, FS H: Axillary tissue Gross Description: A. Received in formalin is a yellow fibroadipose tissue weighing 92 grams, measuring 9.0 x 7.5 x 3.5 cm. The specimen is. oriented with short suture superior margin, long suture lateral margin and double sutures deep margin. The margins are. inked as folows: Superior margin is inked in blue, superior margin inked in green, lateral margin is inked in otange,. medial margin is inked in red, anterior margin inked in yellow and deep margin inked in black. Multiple cross $ections,. there is well demarcated tumor mass 3.0 x 2.4 x 2.4 cm located at approximately 0.7 cm closest margin (and p.4 cm inferior margin). The rest of the breast shows a white diffusely breast tissue and adipose tissue. The stroma to fat ratio is. approximately 30-70%. Representative sections are submitted in twelve cassettes as foilows: Superior margin 2 Inferior margin. 3  Lateral margin Page 2 of 3
+
+--- Page 3 ---
+SURGICAL PATHOL Report 4  Medial margin 5 Anterior margin 6 Deep margin 7  Superior margin with tumor. 8  Inferior margin with tumor. 9-12 Tumor B. Received fresh is a pale tan tissue fragment, 1.2 x 1.0 x 0.2 cm. Submitted in toto in one cassette for frozen|section. C. Received in formalin is a yellow fibroadipose tissue 4.5 x 3.0 x 1.0 cm. The specimen presents multiple black sutures, marking through margin. This margin is inked in yellow and the opposite margin is inked in black. Serially soctioned and submitted in toto in ten cassettes. D.  Received fresh is a yellow fibroadipose tissue 3.0 x 2.0 x 1.0 cm. The specimen is serially sectioned and sutmitted in toto in five cassettes as follows:. 1 For frozen section 2-5 For permanent E. Received are two pink-tan tissue fragments, 1.0 x 1.0 x 0.5 cm each. Submitted in toto in one cassette for frozen. F. Received in formalin is an ovoid pale tan tissue fragment, 3.0 x 1.5 x 1.0 cm. Bisected and submitted in toto fn two cassettes for frozen.. G. Received in formalin is a yellow, ovoid tissue fragment, 3.0 x 2.0 x 2.0 cm. Serially sectioned and submitted n toto in six cassettes for frozen. H. Received in formalin is an ovoid yellow, fibroadipose tissue, 2.0 x 1.5 x 1.5 cm. Serially sectioned and submitted in toto in four cassettes. Page 3 of 3
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diff --git a/output/text/518e156e-4020-4d13-a440-c7918f47631c.txt b/output/text/518e156e-4020-4d13-a440-c7918f47631c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0ba61a163d887c75f00759eba1737ca0a592bab5
--- /dev/null
+++ b/output/text/518e156e-4020-4d13-a440-c7918f47631c.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Surgical Pathology Report Name: Case #: Dob: Collected: Gender: ) Received: MRN: Reported: Locatlon: Copy To: Physician: Pathologic Interpretation: Breast, mastectomy, partia/simple: - Invasive poorly differentiated ductal carcinoma Nottingham grade 3(3+3+3), 8.5 cm in greatest dimension. - Margins are free of tumor (See Tumor Summary). - Metastatic carcinoma to two out of eight lymph nodes (2/8) with extranodal extension. - The largest metastatic deposit 4.5 cm. Tumor summary: Ics - 0 - 3 cavciona. nifyilfnaHng clutl, nos 8500/3 Specimen: - Total breast SiF : brst, Nos c50.9 3f1/n Procedure: - Total mastectomy Lymph Node Sampling: - Axillary dissection Specimen Integrity: UUID:B3B6DE56-F40C-40BF-B6B3-2BC10F695F16 TCGA-Ew-A1PB-01A-pr Redacted - Single intact speclmen Speclmen Laterality: - Right Tumor Site: - Upper outer quadrant Tumor Slze: - Greatest dimenslon of largest focus of invasion over 0.1 cm: 8.5 cm - Additlonal dlmenslons: 7.4 x 5.8 cm. Tumor Focality: - Single focus of invasive carcinoma Macroscoplc Extent of Tumor: - Skin: Invasive carcinoma does not invade into the dermls or epidermis - Skeletal Muscle: No skeletal muscle present. Histologic Type: - Invasive ductal carcinoma.. Histologic Grade (Nottingham Histologlc Score): - Score 3 Nuclear Pleomorphism: - Score 3 Mitotlc Count: - Score 3 Overall Grade: - Grade 3 Margins: - Uninvolved by Invasive carcinoma.  - Distance from closest margin: 5.0 mm (deep). Treatment Effect:  - No known Presurgical therapye In The Lymph Nodes: No known Presurgical therapy. Lymph-Vascular Invasion:. - Present Derma! Lymph-Vascular Invasion: - Not identified. Lymph Nodes: - Total number of lymph nodes examined (sentinel and nonsentinel): 8 - Number of lymph nodes with macrometastases (>0.2 cm): 2 - Size of largest Metastatic deposit: 4.5 cm Extranodal Extenslon: - Present Method of Evaluatlon of Sentinel Lymph Nodes:
+
+--- Page 2 ---
+SURGICAL PATHOL Report - Hematoxylin and eosin (H&E), one leve!. Pathologic Staging (pTNM): - Primary Tumor (pT): pT3 - Regional Lymph Nodes (pN): pN1a. - Distant Metastasis (pM): Not applicable.. Ancillary Studies: - Estrogen Receptor: - Performed on another specimen. : Results: No Immunoreactive tumor cells present.. - Progesterone Receptor: . Results: No Immunoreactive tumor cells present. - Performed on another specimen: - HER2/neu: : Results: Negative (Score 0) - Performed on another specimen: AJCC: pT3, pN1a, M-n/a NOTE: Some immunohistochemicai antibodies are anah'te specific reagenis (ASRs) vulldated by our laboratory. These ASRs are clinically usesul Indirators that do not require FDA approryl. These cones are us 1DS-ER, PgR 636-PR, A485-HER2, i+11-EGFR. Ai immunohistochemical stains are wsed nith formalin or molecular fixed. parafin cmbedded rssue. Deiec tion is by Emtsion Method. The resuils are read by a pashologist as posillve or negalive. As the attending pathologist, I attest that I: (i) Examined the relevant preparation(s). for the specinen(s): and (1t) Rendered the diagnosis(es).. ***Electronically Signed Out By*** Clinical History: Patient is Patient with cT3N1m0 carcinoma right breast - one large palpable mass axillary tail plus main mass in breast. )R done under para-vertebral block. Please evaluate margins and any submitted nodes. Operatlon Performed Right total mastectomy. Pre Operative Diagnosis: Triple negative carcinoma breast Speclmen(s) Received: Breast, mastectomy, partlal/simple Gross Descrlption.. Received in formalin is a mastectomy specimen, measuring 28.0 x 18.0 x 6.5 cm with an ellipse of skin attached, measuring 25.0 x 16.0 cm with a nipple attached. The specimen is oriented with one stitch marking the superior margin, two stitches marking the medial margin. The specimen has been prevlously opened with inked deep margin. Upon serial sectloning, there is an 8.5 x 7.4 .The cut surface appears to be necrotic with foci of x 5.8 cm white lesion located in the upper outer quadrant of the breast..  Additionally, there is a 4.5 x 3.5 hemorrhage. The rest of the breast appear unremarkable with a stroma to fat ratio of 20 to 80%.. x 3.0 cm white-tan firm lesion located in the axilla. Those lesions are approximately 0.3 cm to the deep margin. Representative sections are submitted as follows: 1 Nipple 2 Tumor with skin : Tumor with deep margin Page 2 of 3
+
+--- Page 3 ---
+SURGICAL PATHOL Report Another section of the tumor with deep margin 4 5 Section from the center of the tumor 6 Another section of the tumor, firm area and skin. 7 One more section of the tumor 8 A section of the smaller lesion in the axilla with deep margin 9 Two more sections of the smaller tumor with deep margin 10 Another section of the smaller lesion 11 A section of the breast from the upper inner quadrant. 12 Sectlon of the breast from the inner lower quadrant. 13 Section of the breast from the lower outer quadrant. 14 Section from one possibte lymph node, measuring 3.2 x 1.1 x 1.0 cm 15 One bisected possible lymph node 16 One trisected possible lymph node 17 One bisected possible lymph node One bisected possible lymph node 19 One bisected possible lymph node 20 Adipose tissue with possible lymph node 3/ Page 3 of 3
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index 0000000000000000000000000000000000000000..b8602c9ecaf346c32e1defd437674560eb7d16b8
--- /dev/null
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+
+--- Page 1 ---
+TSS ID: TSS ID. OC ID: Date of Procurement. Gross Description: Breast with the tumor of 3.5 x 3 cm in size; fatty tissue lymph nodes are dense, hyperemic, up to 1 cm in their diameter. Microscopic Description:. Infiltrating duct carcinoma; G2. Ten lymph nodes were examined, nine lymph nodes demonstrated metastases. Diagnosis Details: Tumor Features: Unknown, Tumor Extent: T2 tumor size more than 2cm not more than 5 cm, Venous Invasion: Absent, Margins: Absent, Treatment Effect:. Comments: Formatted Path Report: 1es-0-3 cnrenoma mfHutirg ouctj Nos 8500f3 BREAST TISSUE CHECKLIST 4/8/m1 Site: brsot Nos C50.9 Specimen type: Radical mastectomy Specimen size: Not specified. Tumor site: Upper outer quadrant Tumor size: 3 x 0x 3.5 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinoma. Histologic grade: Moderately differentiated Tumor extent: Not specified Lymph nodes: 9/10 positive for metastasis (Axillary 9/10) Extracapsular invasion of the lymph nodes: Not specified. Margins: Uninvolved  Nottingham Histologic Score. UUID:80831A1A-95BD-4ECD-B7D9-6DDCD5313B25 TcgA-E9-AiRe-01a-Pr Redacted Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined.
+
+--- Page 2 ---
+TSS IC Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None Laterality: Left, upper outer quadrant
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diff --git a/output/text/51a6084d-715b-45bb-832d-ff067dc2e2c5.txt b/output/text/51a6084d-715b-45bb-832d-ff067dc2e2c5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..96ea73a64cf7f0981a89414fd0f217a57028ed0a
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Pathology Form Specimen Information. Collected by: Date Preserved by: Date SPECIMENTYPE(#of samplesprovided):T.. Frozen Paraffin Block Blood/Serum/Plasma Slide Diseased Normal Diseased Normal Diseased  Normal Diseased Norma! 2 2 2 f Time to LN2 Time to Formalin Time to LN2 min /3  min min O PATHOLOGICALDESCRIPTIONRSTL ..... .. Primary Tumor Organ Size Extension of Tumor Distance to NAT Ce llen..Lismer xx cm cm Lymph Nodes Location # Examined # Metastasized Distant Metastasis. Organ Detailed Location Size Pathological Staging pT 3 N M o Stage: Notes: 4
+
+--- Page 2 ---
+Microscopic Description Histological Pattern Cell Distribution + Structural Pattern Diffuse Streaming  Mosaic Storiform Necrosis  Fibrosis Lymphocytic Infiltration Palisading  Vascular Invasion Cystic Degeneration Clusterized  Bleeding  Alveolar Formation  Myxoid Change  Indian File  Psammoma/Calcification TeCellular Differentiationh Squamous [+- Adenomatous Sarcomatous +-  Lymphomatous + Squamoid Cell Glandular cell Round Cell  Large Cell Spindle Cell Cell Stratification Fibroblast Small Cell Keratin Secretion Osteoblast  RS Cell/RS Like  Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell Pear! Gland formation Myoblast  Plasma Cell Cellular Differentiation: Well Moderate i Poor Nuclear Atypia: 0 I II III Aniso Nucleosis  Hyperchromatism  Nucleolar Prominent  Multinucleated Giant Cell  Mitotic Activity X Nuclear Grade: Marker Result Value Date ER  Negative  Positive PR  Negative  Positive Her-2/neu  Negative  Positive B-Celf Marker  Negative  Positive T-Cell Marker  Negative  Positive Other:  Negative  Positive Other:  Negative  Positive Final Pathology Report Aelenecaocincmo ct the Celey Histological Diagnosis:. i LaeRon TeeVeg Grade..I I Maenalel cl Comments:
+
+--- Page 3 ---
+CONSOLIdaTED DIaGNOSTIC PATHOLOgy fORm* Microscopic Appearance: I. Histological pattern: CELL DISTRIBUTION STRUCTURAL PATTERN Diffuse +.  Streaming Mosaic Storiform Necrosis Fibrosis Lymphocytic Infiltration Palisading Vascular Invasion Cystic Degeneration Clusterized Bleeding  Alveolar Formation Myxoid Change  Indian File  Psammoma/Calcification 2. Cellular features: Squamous + Adenomatous + Sarcomatous + -Lymphomatous  Squamoid Cell Glandular cell  Round Cell Large Cel! Spindle Cell Cell Stratification Fibroblast Small Cell  Keratin Secretion Osteoblast RS Cell/RS Like  Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell Pearl Gland formation  Myoblast  Plasma Cell Otherwise Specified: 351. 0r36% D3 357 Dy 3ST Neenor 5 D. 2.Cellular Differentiation: Well  Moderately Poor Nuclear Atypia: 3 Nuclear Appearance Aniso Nucleosis Hyperchromatism  Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity Nuclear Grade Auls'ostnal, b Histological Diagnosis: STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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diff --git a/output/text/51c6ad56-b563-41b1-b4c1-a54f4c6af15e.txt b/output/text/51c6ad56-b563-41b1-b4c1-a54f4c6af15e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ec4514af9c296f414a5cfe8e753d90dd13f800aa
--- /dev/null
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+
+--- Page 1 ---
+JUID:7BE65565-0C63-466C-AE5D-A9B4788354C9 IcD-o -3 TCGA-OR-A5KT-01A-PR Redacted arcinomc ,acreual corteaI 8370/3 Si+e O Adreual Glard cortex. Procedure: L adrenalectomy e74.D Gross description: 7 x 6.3 x 5.3cm, 171gm J z/4l3 Diagnosis: adrenocortical carcinoma with myelolipomatous metaplasia Reference Pathology: Diagnosis: adrenocortical carcinoma with myelolipomatous metaplasia, Kl67 20%, very unusual to encounter myelolipomatous metaplasia in a malignant tumor. However, proliferation rate clearly marks this as malignant Weiss score: 2. Hough score: 1.69 Van Slooten score: 5.7 Pruss -1 F passis gt mmr psW  if nt nhiyrut, hud shigig W yu
+
+--- Page 2 ---
+Patient # from Tissue Source Site Date of report. Date of Surgery/specimen collection Site (confirmed to be adrenal) with laterality indicated Left Tumor size(s) 10.5x8.5x5.5cm Histologic diagnosis ACC Lymph Node Status Unknown Pathologic information T2NxMx Weiss score 2, but diagnosis of ACC by reference pathologist due to KI67 20% 4f14|13. Pw NcI Case may ship as lmg as.. if is Ac(pyodhu y sht) sehasir) BcP Shigpwg m hr/d ihw 41f13 4/1a/13
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diff --git a/output/text/51f1f5d8-a96e-4320-9968-07a2463d5f03.txt b/output/text/51f1f5d8-a96e-4320-9968-07a2463d5f03.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3f0204e219b509f5d878baa92023ae6704c47d80
--- /dev/null
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+
+--- Page 1 ---
+UUID:7547A833-EA2B-48ED-B779-D632A6869FA0 TCGA-XD-AAUH-01A-PR Redacted IQD-O 3 Colenzcarcnena,ductN0S 85oe|3 Site; Yncreas heaeCQs.O Collection date and time OyJ s/xi/14 Clinical Information. Obstruction of bile duct. Acute pancreatitis.. Diagnosis A. LIVER CORE BIOPSY: - Liver tissue with features consistent with bile outflow obstruction.. - No evidence of malignancy. B. LIVER, WEDGE BIOPSY:  - Hyalinized nodule and features of bile outflow obstruction. - No evidence of malignancy. C. COMMON HEPATIC ARTERY LYMPH NODE, BIOPSY: - Three lymph nodes with no evidence of malignancy (0/3). D. PARTIAL PANCREATICODUODENECTOMY: - Invasive moderately to poorly differentiated ductal adenocarcinoma, size: 2.8 cm in maximum  diameter, invading into peripancreatic tissue and wall of small bowel, please see staging summary..  - Seven of twenty-two lymph nodes positive for metastatic carcinoma (7/22). - Perineural invasion identified..  - Common bile duct, pancreatic duct margin and SMA margin negative for malignancy. - Proximal duodenal margin positive for subserosal ductal adenocarcinoma, distal duodenal margin negative. E. LYMPH NODE FROM AORTOCAVAL GROOVE, BIOPSY: - Four lymph nodes with no evidence of malignancy (0/5). Pathology Synoptic Specimen type: Partial pancreaticoduodenectomy Tumor location: Head of pancreas Histologic type: Ductal adenocarcinoma. Histologic grade: G2-3 Tumor size and invasion of: Tumor extends beyond the pancreas, but without involvement of
+
+--- Page 2 ---
+celiac axis or SMA: Yes Tumor involves celiac axis or SMA: No Lymphatic invasion: Identified Large vessel invasion: Not identified Margins: Common bile duct: Negative Proximal duodenal: Positive Distal duodenal margin: Negative Proximal or distal pancreatic margin: Negative Peripancreatic soft tissue margin (including retroperitoneal and posterior. pancreatic margin): Negative Total regional lymph nodes: 30 Number positive: 7 AJCC Pathologic Stage: pT3 N1 (AJCC 7th edition, 2010) Dictated and authenticated by: Performing Location: Gross Description A. CORE LIVER BIOPSY  Received fresh labeled with the patient name Description: The specimen consists of two cylinders of tan-brown tissue having lengths of 0.7 and 1.2 cm and diameters of less than O.1 cm. The specimen is entirely embedded for a frozen section diagnosis. FROZEN SECTION DIAGNOSIS PERFORMED AT No evidence of malignancy. SECTIONS: A1. Frozen section control. B. WEDGE LIVER BIOPSY Received fresh labeled with the patient name Description: The specimen consists of three pieces of tan-brown tissue ranging from O.5-1.0 cm in greatest dimension, each of which reveals a white-tan nodule measuring up to 0.1 cm in greatest. specimen. The specimen is entirely embedded for a frozen section diagnosis.. FROZEN SECTION DIAGNOSIS PERFORMED AT No evidence of malignancy. SECTIONS: B1. Frozen section control.
+
+--- Page 3 ---
+C. COMMON HEPATIC ARTERY LYMPH NODE Received in formalin labeled with the patient name Description: The specimen consists of an irregular piece of yellow-brown tissue measuring 3.1 cm in greatest dimension, from which are retrieved three lymph nodes which are submitted in their entirety.. SECTIONS: C1. One longitudinally bisected lymph node c2. One intact lymph node and one inked and longitudinally bisected lymph node. D. PRODUCT OF PARTIAL PANCREATICODUODENECTOMY: Received fresh labeled with the patient name Specimen received: Product of a partial pancreaticoduodenectomy Orientation given: Two medium length sutures, one long suture and two long sutures identify the bile duct, pancreatic neck and SMA margin respectively, per the intraoperative consultation form. Integrity: The pancreatic component is intact; the duodenum is unopened. Size of pancreas: 6.5 x 6.0 x 3.5 cm Length of duodenum: 19.0 cm. Ducts: Probe patency cannot be demonstrated between the common bile duct and the ampulla.. Ampulla: The ampulla is easily probed from the pancreatic duct. Inking scheme: The anterior and posterior surfaces of the pancreas are inked blue and black respectively. The margins of the common bile duct and the pancreas are inked purple and green. respectively, after the true pancreatic margin is embedded for a frozen section diagnosis. The concavity. created by the portal vein is inked yellow and the SMA margin is inked orange. Tumor site: Within the head of the pancreas Tumor size: Tumor is estimated to measure 2.8 cm in greatest dimension. Tumor description: White-tan, waxy, poorly circumscribed Invasion of: The tumor surrounds the common bile duct, compressing it to a diameter of less than 0.1. cm, having a diameter of 1.7 cm at its margin of resection. Distance from margins: The tumor appears to most closely approximate the pancreatic margin of resection by 0.5 cm, the bile duct margin by 3.0 cm, the anterior blue ink aspect of the pancreas by apparently less than 0.1 cm, the posterior pancreas by 1.0 cm, the concavity created by the portal vein by O.5 cm and the SMA margin by 1.0 cm. Remaining specimen: The small intestinal component has stapled margins of resection, scant serosal adhesions, an average wall thickness of 0.3 cm and an unremarkable mucosa. Peripheral to the tumor the pancreas reveals unremarkable cut surfaces, excepting for a 1.1 cm smooth-walled cyst. Lymph nodes: The lymph nodes retrieved from the specimen are submitted in their entirety. Representative sections are submitted with the pancreatic component being submitted proceeding from the margin towards head.. FROZEN SECTION DIAGNOSIS PERFORMED AT Indicated margins: All negative for carcinoma. SECTIONS: D1. Frozen section control of common bile duct margin D2. Frozen section control of pancreatic margin D3. Frozen section control of SMA margin D4-5. En face proximal and distal duodenal margins, respectively
+
+--- Page 4 ---
+D6-7. Longitudinally bisected ampulla. D8-9. Transverse of common bile duct proceeding from margin towards head with adjacent pancreatic tissue (green ink does not represent a true surgical margin) D10. Approximation of tumor to blue inked anterior pancreatic surface, duodenal wall and green inked cut surface of pancreas D11. Approximation of tumor to concavity created by portal vein including pancreatic cyst and. beginning of stricture of common bile duct. D12. Pancreatic cyst, SMA margin and the posterior surface of pancreas. D13. Compressed bile duct and posterior surface of pancreas D14. Tumor and anterior surface of pancreas D15. Pancreas, SMA margin, posterior surface and one bisected lymph node. D16. Pancreatic tissue and adjacent duodenal wall, posterior surface of pancreas and compressed common bile duct D17. Tumor, anterior surface of pancreas and pancreatic duct D18. Two inked and longitudinally bisected lymph nodes retrieved from anterior surface of pancreas D19-20. Eight intact lymph nodes retrieved from inferior aspect of pancreas with four in each cassette D21. Three intact lymph nodes retrieved from inferior aspect of pancreas D22. Two longitudinally bisected lymph nodes retrieved from inferior pancreas with one inked orange D23. One trisected lymph node retrieved from inferior aspect of pancreas. D24-26. One sectioned lymph node retrieved from anterior pancreas adjacent to common bile duct. E. LYMPH NODE FROM AORTOCAVAL GROOVE Received in formalin labeled with the patient name Description: The specimen consists of an ovoid piece of tan tissue having a diameter of 2.5 cm from which are retrieved multiple suspected lymph nodes which are submitted in their entirety.. SECTIONS: E1. Four intact suspected lymph nodes. E2-3. One longitudinally trisected lymph node. Microscopic Description A. cORE LIVER BiOPsy: Microscopic examination is performed and supports the diagnosis above. B. WEDGE LIVER BIOPsy: Microscopic examination is performed and supports the diagnosis above. C. COMMON HEPATIC ARTERY LYMPH NODE: Microscopic examination is performed and supports the diagnosis above. D. PRODUCT OF PARTIAL PANCREATICODUODENECTOMY: Microscopic examinatiOn is performed and supports the diagnosis above.. E. LYMPH NODE FROM AORTOCAVAL GROOVE: Microscopic examination is performed and supports the diagnosis above.
+
+--- Page 5 ---
+Surg Path Non-Chartable Comment Diagnosis given directly to surgeon over telephone/speaker phone. (parts Aand B) Tumor QC block on part D.; Edited by:
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diff --git a/output/text/51fcd120-88ba-427c-94f4-65ac4abc76d3.txt b/output/text/51fcd120-88ba-427c-94f4-65ac4abc76d3.txt
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index 0000000000000000000000000000000000000000..4489a20fc25cdf8df0251f7da7a3e8da65ce1c45
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+locally R0, additionally a villous adenoma with focally severe dysplasia (intraepithelial neoplasia of the hisk-risk type) and a serrated adneoma and free lymph nodes (pN0).
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diff --git a/output/text/5220e965-2696-46ce-8d92-a3e17fe650fd.txt b/output/text/5220e965-2696-46ce-8d92-a3e17fe650fd.txt
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index 0000000000000000000000000000000000000000..b5d0982e4cea47cfcb8036280a343243de2da3b4
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+SPECIMEN LABELED "KIDNEY FOR TUMOR BANK": RENAL CELL CARcINOMA (20.6 cm), Chromophobe type, Fuhrman nuclear grade II. The, tumor compresses the renal cortex, but does not invade the perirenal adipose tissue. No lymphovascular invasion identified. The renal artery, vein, and ureter margins are negative for tumor. Uninvolved kidney with no significant pathologic change. Adrenal gland; no diagnostic abnormality recognized.. AJcc (6th Edition) Classification: T2 Nx Mx. NoTe: A modified Hale's colloidal iron stain is in progress to confirm the chromophobe features SURGICAL ADDENDUM: SPECIMEN LABELED "KIDNEY The Hale's colloidal iron stain is positive, supporting chromophobe differentiation of RENAL CELL CARCINOMA NOTE: Repeat iron stain (Hale's colloidal iron) and a CK7 impox were performed on selected sections where oncocytoid and chromophobe features overlap. The immunostaining pattern for Ck7 shows diffuse positivity in both areas supporting the diagnosis with chromophobe RENAL CELL CARcINOMA. The diagnosis remains unchanged. CLINICA History CT - large (L) renal mass. Operation: (L) rad, nephrectomy. clinical Diagnosis: (L) renal mass. TISSUE SUBMITTED: #1. (L) kidney. GROSS DESCRIPTION: by SANTAGATA,SANDRO,M.D.,PH.D. The specimen was received fresh, in one part, labeled with the patient's name, medical record number, "Kidney for tumor bank", and consists of a 2277.8 g (12.5 x 12.0 x 11.0 cm) nephrectomy specimen with adrenal gland (12.4 x 2.3 x 0.4cm. There is a renal vein (1.5 cm in length x 0.8 cm in diameter), a renal artery (2.5 cm in length x 0.4 cm in diameter), and ureter (6.2 cm in length x 1.0 cm in diameter proximaly x 0.4 cm in diameter at the margin). There is a 20.6 x 14.0 x 11.0 cm yellow/golden brown and focally hemorrhagic mass which protrudes from the kidney compressing the cortex into a thin rim in the upper pole. The mass is incapsulated by a thin membrane (less than 0.1 cm in dimension).  The mass is ll.5 cm from the ureter, 7.0 cm from the renal vein and 7.8 cm from the renal artery. Representative sections of the mass and normal tissue are submitted to the tissue bank and cytogenetics. The tumor has a large focus of hemorrhage and fibrosis (5.3 x 3.8 x 2.9 cm) as well as multiple areas of necrosis.. Micro 1: Renal artery vein and ureter margins, 3 fraqs Micro 2: Tumor to capsule (inked black) 2 frags Micro 3-5:  Representative section of tumor, 5 frac. Micro 6: Hemorrhagic fibrotic area, 2 frags Micro 7: Tumor to renal cortex, 1 Micro 8 : Tumor to pelvis, 1 frag, Micro 9: Tumor to adrenal, 1 frag. Micro 10: Uninvolved kidney, 2 frag Micro 11: Page: 1 of 2
+
+--- Page 2 ---
+Micro 12: T2 fragment, 2 frags Micro 13: T3 fragment, 1 frag, Micro 14: T4 Page: 2 of 2
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diff --git a/output/text/524ca025-1a4f-4f31-b406-977bc54242b2.txt b/output/text/524ca025-1a4f-4f31-b406-977bc54242b2.txt
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index 0000000000000000000000000000000000000000..3b8ef9866191a301ab5932fe1197d96fea3a54f6
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+
+--- Page 1 ---
+TSS IC TSS iD OC I0 Date of Procurement: Gross Description: Breast with the tumor measuring 2.7 x 2.5 cm. Fatty lymph nodes are soft and hyperemic. Microscopic Description: Infiltrating duct carcinoma; G2. Ten examined lymph nodes demonstrate focal fibrosis and lipomatosis.. Diagnosis Details: Tumor Features: Unknown, Tumor Extent: T2 tumor size more than 2cm not more than S cm, Venous Invasion: Absent, Margins: Absent, Treatment Effect: Comments: Formatted Path Report: lcs-0-3 BREAST TISSUE CHECKLIST Cavcinona, mfttrutiug oluct, ns 850of3 Sit; brust Nus c50.9 pw 4/8/yj Specimen type: Radical mastectomy Specimen size: Not specified Tumor site: Central breast Tumor size: 2.5 x 0x 2.7 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinoma Histologic grade: Moderately differentiated Tumor extent: Not specified Lymph nodes: 0/10 positive for metastasis (Axillary 0/10) Extracapsular invasion of the lymph nodes: Not specified UUID:38E8EA29-3C5F-4339-9CE7-989948545848 Redacted TCGA-E9-A1RB-01A-PR Margins: Uninvolved Nottingham Histologic Score. Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified Tota! Nottingham Score: Score cannot be determined 4T8N
+
+--- Page 2 ---
+TSS ID: Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None Laterality: Left, upper inner quadrant (central)
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diff --git a/output/text/52dea15c-6990-41de-9910-cc23e0318688.txt b/output/text/52dea15c-6990-41de-9910-cc23e0318688.txt
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index 0000000000000000000000000000000000000000..a8b2d98a3218adf6458ad59a849eb7c91add29d7
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+--- Page 1 ---
+Jcs-0 -3 Caicin`umu,mfHntrz ducp/ nrs 85oo/3 PATIENT HISTORY: Site : Srust, Nos CHIEF COMPLAINT/ PRE-OP/ POST-OP DIAGNOSIS: Lef breast cancer. c 50.9 3/28/ LMP DATE. Not applicable. PROCEDURE: Lent segmental mastectomy with wire localization, sentinel node biopsy and mapping. SPECIFIC CLINICAL QUESTION: Not provided. OUTSIDE TISSUE DIAGNOSIS: No PRIOR MALIGNANCY: No. CHEMORADIATION THERAPY: No. OTHER DISEASES: No FINAL DIAGNOSIS: Coloction Date. Part 1: Lymph node, Left axillA, Sentinel node #1, Biopsy -- ONE BENIGN LYmPH NODE, NO EVIDENCE OF mALIGNAnCY (0/1). Part 2: lymph node, Left AxillA, sentinel. node #2, siopsy - One senign Lymph nODe, NO eViDenCeE Of mALignAncy (0/1). Part 3: Breast, Left, segmental mastectomy with wire Localization - A.  InVASIVE DUCtAl CarciNOmA, NOTTINGhAm GRADE 2 (TUBULAR FORmATION: 3, nUCLEAR Pleomorphism: 2, mitotic Activity: 2; total Score 7/9). B. INvasive tumOr measures 1.5 Cm in GReAtest DimensiOn (GrOss Measurement). C.  LymphoVAsCULAR SPACe iNVAsION IS PreSENt. D. Ductal carcinoma in-situ (Dcis), nuclear grade 2, solid type.. E. .ResectiOn mArGiNs Are neGatIve fOr Carcinoma; Carcinoma IS 2 mm From nEareSt (ANTERIOR) MARGIN G. BIOPSY SITE CHANGES. H. CALCifIcaTiONs AssOciated wIth benIgn AnD maLignant AreaS.  TUmOR REPORTeD tO bE POsItIVe fOr eR AND PR, AnD nEgAtiVE fOR her-2/NEU J. rAIHOLOgIC STAGE: pT1a pN0. SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST LAteraLIty: Left PROCEDURE: Segmental LOCATION: Clock position:12:00 SIZE OF TUMOR:  Maximum dimension invasive component: 15 mm  MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: TUMOR TYPE (invasive componont): No Ductal adenocarcinoma, NOS NOTTINGHAM SCORE: Nuclear grade: 2 Tubule formation: 3 Mitotic activity score: 2 Total Nottingham score: 7 Nottingham grade (1. 2. 3): 2 ANGIOLYMPHATIC INVASION: Yes  DERMAL LYMPHATIC INVASION: Nof applicable" CALCIFICATION: Yes, benign zones Yes, malignant zones Tumor type, in situ: Solid Percent of tumor occupied by in silu cornponent: 10 %. SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No Distance of invasive tumor to dosest margin: 3 mm SURG MARGINS INVOLVED BY IN SITU COMPONENT: No Distance of in situ disease to closest margin: 2 mm Lymph noDes POsitive: 0 Lymph NODeS EXAminED: 2 meThOD(S) Of Lymph NOdE eXAmiNAtiON: H/E stain t Stage, pathologic: pT1a N STAGE MODIFIER: (sn) N Stage, PathoLogIC: pN0 UUID:6AE92F6F-E29D-43B6-AF1E-F15720C1AAE8 Redacted M STAGE: Not applicable TCGA-BH-A201-01A-PR ESTROGEn RECEPTORS: positive, H-score: 205 PROGESTERONE RECEPTORS: positive, H-score: 225 HERZ/NEU: 1+
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diff --git a/output/text/52f69ae7-c89d-47e8-84c8-7ca4cae4f0c5.txt b/output/text/52f69ae7-c89d-47e8-84c8-7ca4cae4f0c5.txt
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index 0000000000000000000000000000000000000000..b7f0445768dd55c22dddfb2761a0f6a895fb451f
--- /dev/null
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+
+--- Page 1 ---
+Examination: Histopathological examination Internal invoice No. Cost of diagnostic procedure Material: Partial organ resection -- segment of the large intestine. Expected time of examination: up to 8 working days. Clinical diagnosis: Ca. colonis. SPECIMEN - transverse colon with tumour. Examination performed on: Macroscopic description: A 25.3 cm length of the large intestine with a segment of the mesentery sized 25 x 6 x 2 cm. Ulcerous tumour sized 3 x 2 cm found in the mucosa. The lesion surrounds 100% of the intestine circumference, narrowing its lumen, removed 4.5 cm away on e of the incision lines and 4.5 cm from the opposite one. The lesion infiltrates macroscopically the wall of the large intestine and the periintestinal tissue. Minimal side margin is 1 cm. Mucosa unchanged outside the tumour.. Microscopic description: Adenocarcinoma tubutare (Gl). Infiltratio carcinomatosa tunicae muscutaris propriae et telae adiposac pericolicae. Minimal side margin is 1 cm. Incision lines free of neoplastic lesions. Lymphonodulitis reactiva Iymphonodorum (No XII) Histopathologic diagnosis: Adenocarcinoma tubutare coli (Gl, Dukes B, Astler-Coller B2, pT3, pNO).. Compliance validated by: CONTACT YOUR DOCTOR WITH THIS REPORT!
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diff --git a/output/text/530460f1-12da-4420-8116-64ae9e28caaa.txt b/output/text/530460f1-12da-4420-8116-64ae9e28caaa.txt
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index 0000000000000000000000000000000000000000..24c6b587548dc95cacdff513adde426ccb53577e
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+
+--- Page 1 ---
+FINAL DIAGNOSIS: Part 1: Sentinel Lymph nOde #1, Left AxiLLA, DissectiOn  One Lymph nODe, negative fOr metastatic Carcinoma (0/1) (See COmment). Part 2: SentineL Lymph nOde #2, LEft AxilLA, BiOpsy - ONE LYMPH NODE, NEGATIVE FOR METASTATiC CARCINOMA (0/1) (SEE COMMENT). Part 3: Sentinel Lymph node #4, Left axILLA, BiOpsy - One Lymph nODE, nEgATIVe FOR mEtaStaTiC CArciNOmA (0/1) (SEE COmmenT). PARt 4: Sentinel Lymph nODe #5, Left AxiLlA, biOpsy - One Lymph NODE, nEgATIVE fOR mETASTaTIC CARcINOMA (0/1) (SEE COMmenT). Part 5: Sentinel Lymph nOde #3, Left AxillA, biopsy -- ONe Lymph nODe, negaTive fOR metAStaTic CarcinOmA (0/1) (SEE COmment). Part 6: palpable Lymph node #1, Left axilia, biopsy -- ONE LYMPH NODE, NEGATIVE fOR METASTATIC CARCINOMA (0/1). Part 7: non-sentinel Lymph node, Left Axilla, Biopsy - ONE LYMPH NODE, NEGATIVE FOR METASTAT!C CARCINOMA (O/1). part 8: palpable Lymph node #2, biOpsy - ONE LYMPH NODE, NEGATIVE FOR METASTATIC CARCINOMA (0/1). Part 9: breast, Left, segmental mastectomy -- ^A.* InVasive DUctal CArcinomA, 2.0 Cm (GROSs), nOTTinGhAm GRadE 3 (COmbIned NOTTinghAm SCORE: g79; TUBULE fORMATION 3/3, mITOTIC ACTIVITY 3/3, nUCLEAR PLEOmORPHISM 3/3). B. DUCTAL CARCInOmA IN SItU, nUCLEAR GRADE 3, SOLID WITH COMEDO NECROSIS AND ASSOCIATED MICROCALCIFICATIONS, ADMIXED WITH iNVASIVE TUMOR AND COMPRISES 10% OF TUMOR MASS. C. LYMPHOVASCULAR INVASION IS NOT IDENTIFIED. D. MArGIns free. E. ATyPICAL DUCTAl EPITHeLiAL HYPERPLASIA. F.  FIBROADENOMATOID NODULE 1Cs-0-3 G. Ductal ePIThelial hyperpLASiA. Cavnoa, mnfitratng cdtutl, Nts 8500/3 H. PATHOLOGIC STAGE (see comment). SYNOPTIC - PRIMARY iNVASIVE CARCINOMA OF BREAST Sih:bust Nos c5o,9 3/13/1 LATerALITy: PROCeDUrE: Left LOcATION: Segmental SIZE OF TUMOR:  Not specified MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:  Maximum dimension invasive component: 2.0 cm TUMOR TYPE (invasive component): No NOTTINGHAm SCORE: Ductal adenocarcinoma, NOS Nuclear grade: 3 Tubule formation: 3 UUID:14CE78F3-8F84-476D-A09C-AE87F7919077 Mitotic activity score: 3 TCGA-BH-A0BW-01A-PR Redacted Total Nottingham score: 9 ANGIOLYMPHATIC INVASION: Nottingham grade (1, 2, 3): 3 DERMAL LYMPHATIC iNVASION: No CALCIFICATION:  Not applicable TUMOR TYPE, IN SITU: Yes, malignant zones SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: Solid, DCiS admixed with invasive carcinoma. SURG MARGINS INVOLVED BY IN SITU COMPONENT: No Lymph NODES POSITIVE: No LYMPH NODES EXAMINED: 0 METHOD(S) OF LYMPH NODE EXAMINATION: 8 NON-NEOPLASTIC BREAST TISSUE: ADH H/E stain, Keratin stain t Stage, PathologIc: N Stage, pathologiC: pT1 M Stage, pathologiC: pNO ESTROGEN RECEPTORS: pMX PROgesterOne ReceptOrS: previously performed HER2/NEU: previously performed zero or 1+
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diff --git a/output/text/5372400c-1429-4246-8358-e4cec95aaef0.txt b/output/text/5372400c-1429-4246-8358-e4cec95aaef0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c7ff15e022b0b1cfbdaafed84e33428a984f526d
--- /dev/null
+++ b/output/text/5372400c-1429-4246-8358-e4cec95aaef0.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+Clinical Diagnosis & History: Palpable right breast mass with core biopsy showing invasive cancer. Specinens Submitted: SP: Sentinel node #1. level 1, sight axilla. SP:  Sentinel node #2, level i, right axilla 3: SP: Sentinel node #3, level 2, right axilla. SP: Right breast 5: SP: Sentinel nodes #4 and #5, level 1, right axilla 6 : SP: Non-sentinel nodes right axilla .. DIAGNOSIS: 1) LYMPH NODE, SENTINEL #1 LEVEL I RIGHT AXILLA; BIOPSY: - ONE BENIGN LYMPH NODE (O/1). - ADDITIONAL H/E LEVELS AND CYTOKERATIN (AE1:AE3) IMMUNOSTAINS ARE ALSO) NEGATIVE FOR METASTATIC TUMOR. 2) LYMPH NODE. SENTINEL #2 LEVEL I RIGHT AXILLA; SIOPSY: - ONE BENIGN LYMPH NODE (O/1).  ADDITIONAL H/E LEVELS AND CYTOKERATIN (AEI:AE3) IMMUNOSTAINS ARE ALSO) eJetg8 NEGATIVE FOR METASTATIC TUMOR. 3) LYMPH NODE, SSNTINEL #3 LEVEL II RIGHT AXILLA; BIOPSY: - ONE BENIGN LYMPH NODE (O/1). ADDITIONAL H/E LEVELS AND CYTOKERATIN (AE1:AE3) IMMUNOSTAINS ARE ALSO NEGATIVE FOR METASTATIC TUMOR.S 4) BREAST, RIGHT; TOTAL MASTECTOMY: - INVASIVE DUCTAL CARCINOMA, MODERATELY DIFFERENTIATED WITHS SOLID-PAPILLARY GROWTH PATTERN AND MUCINOUS DIFFERENTIATION, MEASURING 2.2 "yee!o! CM IN LARGEST DIMENSION MICROSCOPICALLY. FOCAL DUCTAL CARCINOMA IN SITO (DCIS). SOLID-PAPILLARY, SOLID AND) CRIBRIFORM TYPES WITH LOW TO INTERMEDIATE NUCLEAR GRADE AND MINIMAL NECROSIS. NIPPLE,  SKIN AND SURGICAL MARGINS ARE NEGATIVE FOR TUMOR. m NO CONVINCING EVIDENCE OF LYMPHOVASCULAR INVASION. - PREVIOUS BIOPSY SITE CHANGES, STROMAL FIBROSIS AND ATROPHY.S IMMUNOHISTOCHEMICAL STAINS WERE PERFORMED ON FORMALIN-FIXED TISSUE WITH THE FOLLOWING RESULTS FOR INVASIVE CARCINOMA (BLOCK "T3"): b05p Continued on aext page ** son'#r9:rf!S
+
+--- Page 2 ---
+ESTROGEN RECEPTOR (6FI, WITH STRONG INTENSITY 1003 NUCLEAR STAINING rdye 4 or > PROGESTERONE RECEPTOR (1E2:) WITH MODERATE INTENSITY 5t NUCLEAR STAINING HER-2/NEU (HercepTest; INTENSITY OF O) NEGATIVE (STAINING 5) LYMPH NODES, SENTINEL #4 AND #5 LEVEL I RIGHT AXILLA; EXCISION: TWO BENIGN LYMPH NODES (O/2). 6) LYMPH NODES, NON-SENTINEL RIGHT AXILLA; EXCISION: - FIVE BENIGN LYMPH NODES (O/5). I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATICN OF THE SLIDES (AND/OR OTHER MATERIAL). AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Report Electronically Signed Out ***. Special Studies: Result Special Stain RECUT Comnent Gross Description: 1) The specimen is roceived fresh for frozen section consultation,. labeled "Sentinel node #1, level one. right axilla" and consists of a single piak tan firm lymph node measuring 1.2 cm in greatest dimension.. and entirely submitted for frozen section.. Bisected Summary of sections: FSc - frozen section control 2) The specimen is received. labeled -Sentinel node #3, level 1, right axilla- and consists of a pink tan  fresh for frosen section consultation. firm lymph node measuring 0.5 cm. Entirely submitted for frozen section. Summary of sections: FSc - frozen section control 3) labeled rSentinel node #3, level 2. right axilla" and consists of a single pink tan firm lymph node measuring 0.8 cm.. for frozen section.  Bisected and ontirely submitted *. Continued on next page *
+
+--- Page 3 ---
+Surmary of sections: Fsc - frozen section control 4) The specimen is received fresh labeled, *Right breast. stitch marks axillary taii- and consists of a breast measuring 25.2 x 24.6 x 3.2 cm with overlying skin ellipse measuring 15.1 x 14.6 cm. skin surface is an everted nipple messuring 1.1 cm and areola measuring 4.1.  Situated centrally on the. x 4.2 cm. There is no sear on the skin surface. axillary aspect.  The posterior surface of the breast is inked black and the A suture demarcates the axillary aspect is inked green. reveal a 2.5 x 2.2 x 2.3 cm well circumscribed, brown, focally hemorrhagic The specimen is serially sectioned to mass located at the li o'clock axis (upper outer quadrant), 0.9 cm from the deep margin. A metallic clip is identified adjacent to this lesion. Additionally, a 1.7 x 1.5 x 1.5 cm tibrous area with areas of hemorrhage and necrosis is present inferior to the 2.5 cm mass in the l1 o'clock axis in the retroareolar region.  The cut surfaces are conposed of 60% fatty and 40% fibrous tissue. No other masses or lesions are grossly identified. Sectioning of the axillary aspect reveals no grossly identifiable lymph nodes. Tissue submitted for tps.  Representative sections are submitted. Summary of sections:. N - nipple NB - nipple base deep margin tumor UIQ inner quadrant LIQ lower inner quadrant UOQ upper outer quadrant LOQ lower outer  quadrant RA retroareolar fibrous tissue 5) The specimen is received in formalin labeled, "Sentinel aodes #4 and 5. level 1, right axilla", and consists of two tan lymph nodes measuring 2 cm and c.8 cm respectively. Both are bisected and entirely submitted.. iarger lymph node (bisected and submitted in two cassettes) SLN smaller lymph node 6 The specimen is received in formalin, labeled *Non-sentinel nodes right axilla- and consists of multiple pink tan firm lymph nodes rarging from o.2 cm to 2.1 cm in greatest dimension. Submitted.  All identified lymph nodes are Summary of sections: LN - lymph nodes BLN - bisected lymph node. *+ Continued on next page *
+
+--- Page 4 ---
+Summary of Sections: Part 1:  SP: Sentinel node #1, level 1, right axilla Block Sect. site 1 PCs FSC 1 Part 2: SP: Sentinel node #2, level 1. right axilla Block Sect. site *. PCs FSC 1 Part 3: SP: Sentinel node #3. level 2, right axilla Block Sect. Site 1 PCs FSC 1 Part 4: SP: Right breast Block Sect. Site 1 PCs 1 D LIQ LOQ 2 N 1 1 UIQ tOQ r r Part 5: SP: Sentinel nodes #4 and #5. level 1, right axilla Block Sect. site 2 PCs LLN 1 N H SLN Part 6: Sp: Non-sontinel nodes right axilla Block Sect. site rd q ri BLN PCs H N LLN LN 1 Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. ** Continued on next page **
+
+--- Page 5 ---
+ FROZEN SECTION DIAGNOSIS:S RIGHT AXILLA SP: SENTINEL NODE #1, LEVEL 1. : BENIGN LYMPH NODE.  PERMANENT DIAGNOSIS: SAME 3) FROZEN SECTION DIAGNOSIS: RIGHT AXILLA SP: SENTINEL NODE #2. LEVEL 1. : RENIGN LYMPH NODE, MAINLY FIBROFATTY WITH SCANTY LYMPHOID TISSUE. PERMANENT DIAGNOSIS: Same 3) FPOTEN CECTION DIAGNOSIS: RIGHT AXILLA SP:SENTINEL NODE #3,LEVEL2, : BENIGN LYMPH NODE. PERMANENT DIAGNOSIS: SAME Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 1) FRO7EN CrCTION DIAGNOSIS: RIGHT AXILLA : BENIGN LYMPH NODE. MOnS #1, LEVEL 1, PERMANENT DIAGNOSIS: SAME 2) Frn7 CnAION DIAGNOSIS: RIGHT AXILLA SP: SENTINEL NODE #2. LEVEL 1. : AENIGN LYMPH NODE, MAINLY FIBROFATTY WITH SCANTY LYMPHOID TISSUE. PERMANENT DIAGNOSIS: SAME 3 ION DIAGNOSIS: RIGHT AXILLA SP: SENTINEL NODE #3, LEVEL 2,  BENIGN LYMPH NODE.  PERMANENT DIAGNOSIS:  SAME ** End of Report
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diff --git a/output/text/53958540-2b60-48ab-92c8-6db55050a933.txt b/output/text/53958540-2b60-48ab-92c8-6db55050a933.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c20c6aa96852e41fd468e311e69ec6d98bc27fbe
--- /dev/null
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@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+Clinical Diagnosis & History:. Leit breast iump. FNA adenocarcinoma; core biopsy Irdc.. Specimens Submitted: 1: sp: Sentinel node #1, level one, left axilla (fs) 2: SP:  Sentinel node #2, level one, left axilla (fs) 3: Sp: Left breast 4: sp: Levels I and + left axillary contents 5: SP: Levels II and III left axillary contents DIAGNOSIS: 1) LYMPH NODES, SENTINEL #1, LEVEL I, LEFT AXILLA; BXCISION: - TWO BENIGN LYMPH NODES (0/2). 2) LYMPH NODES, SENTINEL #2, LEVEL I, LEFT AXILLA; EXCISION: - ONE OF ONE LYMPH NODE POSITIVE FOR METASTATIC CARCINOMA (1/1). - EXTRANODAL EXTENSION IS NOT PRESENT.S 3) BRBAST, LEFT; MASTECTOMY: - INVASIVE DUCTAL CARCINOMA, NOS TYPE, HISTOLOGIC GRADE III/III (SLIGHT OR NO TUBULE FORMATION).S UUID:E8A43FF3-3D98-45EE-9567-6EED4DA38274 SIZE AND SHAPE), MEASURING 6 CM IN LARGEST DIMENSION  NUCLEAR GRADE III/III (MARKED VARIATION IN TCGA-AO-A03D-01A-PR Redacted - THE INVASIVE CARCINOMA IS LOCATED IN THE UPPER OUTER QUADRANT.  GROSSLY. - NO INVOLVEMENT OF THE NIPPLE BY CARCINOMA IS IDENTIFIED. CALCIFICATIONS ARE PRESENT FOCALLY IN BENIGN BREAST PARENCHYMA. - VASCULAR INVASION IS PRESENT.S - NO INVOLVEMENT OF THE SURGICAL MARGINS BY INVASIVE CARCINOMA IS IDENTIFIED. - NO SKIN INVOLVEMENT BY CARCINOMA IS IDENTIFIED.S - THE ATTACHED SKELETAL MUSCLE IS NEGATIVE FOR TUMOR. - THE NON-NEOPLASTIC BREAST TISSUE SHOWS FLORID PAPILLOMATOSIS OF THE NIPPLE, BIOPSY SITE CHANGES, FIBROCYSTIC CHANGES, AND SCLEROSING ADENOSIS.  THE LYMPH NODE STATUS IS AS FOLLOWS (EXPRESSED AS THE NUMBER OF POSITIVE LYMPH NODES IN RELATION TO THE TOTAL NUMBER OF LYMPH NODES EXAMINED) : 2/4. THERE IS NO EXTRANODAL EXTENSION OF CARCINOMA. - ONE BENIGN INTRAMAMMARY LYMPH NODE (O/1). 4) LYMPH NODES, LEFT AXILLARY, LEVELS I AND II; EXCISION: - EIGHT BENIGN LYMPH NODES (0/10).) 1c s-0 -3 *+ Continued on next page ** Site : AreaoT,Nos c50.9 lw 10/35/y j23/11
+
+--- Page 2 ---
+LYMPH NODES, LEFT AXILLARY, LEVELS II AND III; EXCISION: NINE BENIGN LYMPH NODES (O/9). I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. *** Report Electronically Signed Out *** Special Studies: Result Special Stain Comment RECUT RECUT ER-C PR-C HER2-C NEG CONT IMM RECUT NEG-HER2 Gross Description: 1)  The specimen is received fresh for frozen section, labeled "Sentinel node #1, level 1, left axilla". It consists of two lymph nodes measuring 1.0 and 0.5 cm. They are bisected and entirely frozen. Summary of Sections: Fsc - Frozen section control 2)  The specimen is received fresh for frozen section, labeled "Sentinel node #2, level 1, left axilla". It consists of one large lymph node, measuring 2.5 cm. The specimen is bisected and submitted in two cassettes.. Summary of Sections: Z FSCA - J Frozen section control A FSCB - Frozen section control B 3) The specimen is received fresh, labeled "Left breast. Stitch marks axillary tail". It consists of a 34 x 22 x 6 cm mastectomy with a 30 x 12 cm ellipse of skin and a 1.5 cm everted nipple. A mass is palpable in the 12-3:0o position and the axillary tail is designated by a long black suture. The specimen is serially sectioned, revealing a 6.0 x 5.0 x 2.8 cm ** Continued on next page
+
+--- Page 3 ---
+ ill-defined mass, grossly 2 cm from the deep margin. ----- Page 3 of 5- lymph nodes are identified in the axillary tail, ranging from 0.3 to 3.5 cm. Multiple A 'single intramammary lymph node is identified. TPS is submitted.  All lymph nodes are submitted. Summary of Sections: N - Nipple DM - Deep margin. MASS - Multipie sections of the mass LOQ - Representative lower outer quadrant. UIQ Representative upper inner quadrant. LIQ - Representative lower inner quadrant. SK - Representative skin IMLN  - Single intramammary lymph node LN -  Multiple lymph nodes BLN - Bisected lymph node SSLN - Largest serially sectioned lymph node. 4) The specimen is received in formalin, labeled "Lavels 1 and 2, left axillary contents". It consists of an 11 x 7 x 2 cm lobulated portion of fibrofatty tissue, with palpable lymph nodes ranging in size from 0.5 to 1.4 cm. A portion of a grossly positive lymph node is submitted for Tps. lymph nodes are submitted.. Al1 Summary of Sections:. LN - Single lymph node per cassette 5)  The specimen is received in formalin, labeled "Levels 2 and 3 left axillary contents". It consists of a 3.0 x 2.0 x 1.5 cm lobulated, fatty tissue fragment with palpable lymph nodes. All lymph nodes are submitted.. Summary of Sections: LN - Lymph nodes 3 Summary of Sections: Part 1: SP: Sentinel node #1, level one, left axilla (fs) Block Sect. Site PCs 1 fsc 1 Part 2: SP: Sentinel node #2, level one, left axilla (fs) Block Sect. Site 1 PCs fsca 1 ** Continued on next page **.
+
+--- Page 4 ---
+1 Part 3: SP: Left breast Block Sect. Site PCs 1 bln 1 1 dm imln 1 liq 2 1n 2 1oq 4 mass H H n sk 42 8sIn uiq 2 2 uoq 2 Part 4: SP: Levels I and II left axillary contents Block Sect. site PCs 10 In 10 1 tpsln 1 Part 5: SP: Levels II and IIr left axillary contents Block Sect. Site PCs 4 1n Procedures/Addenda: Addendum Date Ordered: Status: Date Complete;  Signed Out By: Date Reported Addendum Diagnosi ADDENDUM SITE: LEFT BREAST PART #3. ER:  90% OF NUCLEAR STAINING WITH MODERATE INTENSITY. PR: 40% OF NUCLEAR STAINING WITH MODERATE INTENSITY. HER2/NEU (HERCEPTEST) : NEGATIVE (STAINING INTENSITY OF 1+). MD ** Continued on next page
+
+--- Page 5 ---
+Irtr'aoperative Consultation:. Note: tissue sample examined at the time of the intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS: BENIGN (0/2). PERMANENT DIAGNOSIS: SAME. 2  3ECTION DIAGNOSIS: METASTATIC CARCINOMA IN ONE LYMPH NODE (1/1). PERMANENT DIAGNOSIS: Same. MD s ** End of Report.
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diff --git a/output/text/539cdee2-87fe-47b3-ac1e-acab83750286.txt b/output/text/539cdee2-87fe-47b3-ac1e-acab83750286.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a86f6cb4278e3f895228cc213807326af59c586f
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+1cD-0-3 Carciona, mifiltnratirg ductal, nos 8500/3 1/28/ ID#: Sin. brst, Nos C50.9 Pathology Form Specimen Information Date: Time: Collected by: ime: Preserved by: . Date: r SPECIMENTYPE(# of samplesprovided)x / Blood/Serum/Plasma Slide Paraffin Block Frozen Diseased  Normal Diseased Normal Diseased Normal Diseased Normal x Time to LN2 Time to LN2 Time to Formalin min  min min POSAESNPATHOLOGIGALDESCRIPTIONMNR Primary Tumor Extension of Tumor Distance to NAT Organ Size Ryrcat 2.5x Cafrllke nodal 2 cm X cm Lymph Nodes # Examined # Metastasized Location Axilla Distant Metastasis Detailed Location Size Organ Pathological Staging M o Stage: pT p N 4 Notes: UUID:8A64D890-ABEF-4AF2-8915-D17DA89B8FC5 Redacted TCGA-C8-A12W-01A-PR
+
+--- Page 2 ---
+ID#: Microscopic Description w.w .Histological Pattern. . Cell Distribution + Structural Pattern. +  Diffuse  Streaming Mosaic  Storiform  Necrosis Fibrosis  Lymphocytic Infiltration  Palisading Vascular Invasion Cystic Degeneration f Bleeding. Clusterized  Alveolar Formation  Myxoid Change Indian File  Psammoma/Calcification Cellular Differentiation Squamous Adenomatous + Sarcomatous + Lymphomatous  Squamoid Cell Glandular cell Round Cell  Large Cell Spindle Cell Cell Stratification  Fibroblast Small Cell Keratin Secretion  Osteoblast RS Cell/RS Like Desmosome Intracyt. Vacuole  Lipoblast  Inflam. Cell Pear!  Gland formation Myoblast Plasma Cell Cellular Differentiation: Well Moderate X Poor wanNuclearAppearanceshs Nuclear Atypia: 0 1 II III Aniso Nucleosis F Hyperchromatism Nucleolar Prominent + Multinucleated Giant Cell  Mitotic Activity Nuclear Grade: Data Result Value Date Marker ER  Negative  Positive PR Negative  Positive Her-2/neu  Negative  Positive B-Cell Marker  Negative  Positive T-Cell Marker  Negative  Positive Other:  Negative   Positive Other:  Negative  Positive Final Pathology Report Luvasue Duchl Caruumma Histological Diagnosis: Grade: Comments: Pathologist Date Principal Investigator
+
+--- Page 3 ---
+COnsOLIdateD DIagnOstIic patholOgy fOrm* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION Diffuse + STRUCTURAL PATTERN  Streaming +1 Mosaic K Necrosis Storiform Lymphocytic Infiltration Fibrosis Vascular Invasion x Palisading Clusterized Cystic Degeneration Alveolar Formation Bieeding Indian File Myxoid Change 1Psammoma/Calcification 2. Cellular features: Squamous +. Adenomatous  Squamoid Cell +  Sarcomatous Glandular cel! + Lymphomatous Round Cel! + Spindle Cell Cell Stratification Large Cell Fibroblast Keratin Small Cell Secretion Osteoblast  RS Cell/RS Like  Desmosome Intracyt. Vacuole Lipoblast Inflam. Cell Pear! Gland formation Myoblast Plasma Cell Otherwise Specified: D,6o7 Dy60Z D soZ Ne pos k Zo Dh 2.Cellular Differentiation: Well Moderately Poor 4 Nuclear Atypia: Nuclear Appearance  Aniso Nucleosis Hyperchromatism  Nucleolar Prominent Multinucleated Giant Cel! Mitotic Activity Nuclear Grade Histological Diagnosis: Lpltoa/sy btta( Cashmg, Ags T ML: Careshimg netoetgsi3edto LN Comments:  Date . PATHOLOGIST STAFF FOR RESEARCH USE ONLY). NTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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diff --git a/output/text/53a2ea2b-dd75-4f21-b31a-8bdbe4b40b26.txt b/output/text/53a2ea2b-dd75-4f21-b31a-8bdbe4b40b26.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2a662f1315fcdc99e3e5cbd61ad8417cf7b535a3
--- /dev/null
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+
+--- Page 1 ---
+1c5-0-3 8500/3 Carcinonu,m^flt^ah`ng owct N0s C50.9 Site Code:breost, Nos 1s|21|10 p Final Diagnosis Breast, left, modified radical mastectomy: Infiltrating ductal carcinoma, Nottingham grade II (of III) [tubules 3/3, nuclei 2/3, mitoses 2/3; Nottingham score 7/9], forming a mass (2.8 x 2.3 x 2.1 cm) located in the retroareolar region of the breast. Ductal carcinoma in situ is absent. Angiolymphatic invasion is absent. Calcifications are not seen. The tumor involves the overlying skin [AJCC pT4]. All surgical resection margins, including the skin and deep margins, are negative for tumor (minimum tumor free margin, 1.1 cm, anterior superior margin). A single (of 23) left axillary mid/low lymph node is positive for metastatic carcinoma. The positive lymph node (1.7 cm in greatest dimension) shows extranodal extension. Lymph nodes, left high axillary, excision: Multiple (2) left high axillary lymph nodes are negative for tumor. UUID:5AD5838F-5CC1-4A2F-96E6-F344D8FE0149 Redacted
\ No newline at end of file
diff --git a/output/text/53b25c5d-fa25-4f40-b541-46d68d28dafe.txt b/output/text/53b25c5d-fa25-4f40-b541-46d68d28dafe.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c59035c1b5fe63c7110a6fe4b58bf8c5103d08b6
--- /dev/null
+++ b/output/text/53b25c5d-fa25-4f40-b541-46d68d28dafe.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:16F7804A-4A67-437C-9657-903F2124012E TCGA-2Z-A9JL-01A-PR Redacted I4D-0:3 Cereinne, yeaellere Pathology Report Nenol eell' l 8Q6o/3 Oite: QYidny NoS Cb4.9 Final Diagnosis A. RIGHT KIDNEY, PARTIAL NEPHRECTOMY: Renal cell carcinoma, papillary type 1. See Key Pathological Findings and Comment B. RIGHT KIDNEY, DEEP MARGIN: Benign renal parenchyma. the attending pathologist, personally reviewed all slides I, and / or materials and rendered the final diagnosis. Electronically Signed Out by Comment Immunoperoxidase stains performed on block A3 show the tumor cells positive for vimentin, CK7, AMACR, AE1/AE3, CAM5.2, EMA and foca|y positive for CD10. Key Pathological Findings. A: Kidney Resection PROCEDURE: Partial nephrectomy SPECIMEN LATERALITY: Right TUMOR SITE: Not specified TUMOR SIZE (largest tumor if multiple): Dimension: 1.7 cm TUMOR FOCALITY: Unifocal MACROSCOPIC EXTENT OF TUMOR: Tumor limited to kidney HISTOLOGIC TYPE:S  Papillary renal cell carcinoma SARCOMATOID FEATURES: Not identified TUMOR NECROSIS: Not identified HISTOLOGIC GRADE (Fuhrman Nuclear Grade): G2: Nuclei slightty irregular, approximately 15 microns; nucleoli evident PATTERN OF GROWTH:
+
+--- Page 2 ---
+ Papillary MICROSCOPIC TUMOR EXTENSION: Tumor limited to kidney. MARGINS: Margins uninvolved by carcinoma ANGIOLYMPHATIC INVASION: Absent PRIMARY TUMOR (pT): pT1a:Tumor 4 cm or less in greatest dimension, limited to the kidney REGIONAL LYMPH NODES (pN): pNX: Regional lymph nodes cannot be assessed DISTANT METASTASIS (pM): pMX PATHOLOGIC FINDINGS INNONNEOPLASTIC KIDNEY Insufficient tissue (partial nephrectomy specimen with <5 mm of adjacent nonneoplastic kidney) Specimen(s) Received A RIGHT PARTIAL NEPHRECTOMY FS B DEEP MARGIN FS Clinical History None given. Preoperative Diagnosis Right renal mass. Intraoperative Consultation FSA1. RIGHT PARTIAL NEPHRECTOMY: Papillary tumor, focally extending to inked margin. FSB1.  DEEP MARGIN:  Margin negative. Comment: This frozen section diagnosis/result was communicated to and acknowledged by Dr  have performed the intraoperative consultations and issued the above diagnosis. Gross Description A. The specimen is received fresh. Part A labeled *right partial nephrectomy, ink is margin". The specimen consists of a partial nephrectomy which measures 2 x 1.8 x 1.6 cm. Prior to sectioning the specimen is inked as follows: Blue: Renal capsule Black: Parenchymal resection margin.
+
+--- Page 3 ---
+The specimen is serially sectioned to reveal an irregular to roughly ovoid, ill-defined, rubbery intraparenchymal tumor which measures 1.7 x 1.5 x 1.3 cm. The tumor bulges capsule and extends to within less than 0.1 cm of the ciosest parenchymal resection margin. The cut surface of the tumor is variegated, pale-yellow to pink, focally hemorrhagic. No foci of necrosis are grossly identified. Representative sections of the specimen are submitted to the Tissue Procurement Laboratory. Representative section of the tumor in relation to the closest inked black parenchymal resection  margin is submitted for trozen section as FSA1. The remainder of the specimen is serially sectioned and submitted entirely in 6 cassettes,A2-A7 B. Part B labeled "deep margin, ink is margin*. The specimen consists of an irregular, oriented fragment of tan-brown renal parenchyma measuring 1.5 x 0.5 x 0.2 cm. Prior to sectioning the total resection margin is inked black. The specimen is bisected and submitted entirely for frozen section as FSB1. Pr
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diff --git a/output/text/53c3b48f-bebc-485c-a223-81384ea55dd7.txt b/output/text/53c3b48f-bebc-485c-a223-81384ea55dd7.txt
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index 0000000000000000000000000000000000000000..e69a7d71a6702eda5ac90dc096f59d2528b800ce
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+******* MODIFIED REPORT-REVIEW ADDENDUM SECTION DIAGNOSIS A CONTENTS RIGHT LEVELINECKDISSECTION METASTATIC SQUAMOUS CELL CARCINOMA IDENTIFIED IN ONE OF FIVE LYMPH NODES (1/5) No extracapsular extension B CONTENTS,LEFT SUPRAOMOHYOIDLEVELIAIB.IABAND One benign lymph node 0/1) and benign salivary gland tissue within level IAno tumor present Three benign lymph nodes 0/3within level B".no tumor present Two benign lymph nodes 0/2) within level lA.no tumor present. Three benign lymph nodes 0/3) within level B,no tumor present Nine benign lymph nodes 0/9 within level l,no tumor present. THERE IS SOFT TISSUE INVOLVEMENT OF METASTATIC PCORLY DIFFERENTIATEDCARCINOMA WITHIN LEVELI CPOSTERIOR LEFT GP SULCUS No tumar present. DLEFT BASE OF TONGUE No tumcr present. E RGHT GINGIVAL MARGIN INVASIVE POORLYDIFFERENTATED SQUAMOUS CELL CARCINOMA FRIGHT FLOOR OF MOUTH: No tumor present. (G ANTERIOR LABIAL MARGIN No tumor present. H ANTERIOR ORAL TONGUE No tumor present I COMPOSITE RESECTION LEFTHEMIMANDIBULECTOMY: INVASIVE POORLYDIFFERENTIATED SQUAMOUS CELL CARCINOMA (3.O CM IN DEPTH) PERINEURAL AND LYMPHOVASCULAR INVASION IDENTIFIED. JRIGHT GINGIVAL MARGIN,INFERIOR No tumor present. KRIGHT GINGIVAL MARGIN No tumor present. LRIGHT MANDIBLE Pending decalcification MTEETH Benign teethgross only Entire report and diagnosis completed b GROSS DESCRIPTION Page 10f4 Surgical Pathology Report File under.Pathology
+
+--- Page 2 ---
+A CONTENTS RIGHT LEVEL 1 NECK DISSECTIONAn irregular fragment of fibrous adipose tissue (6.0 x 3.0 x1.5 cm. The specimen is serially sectionedA possible submandibular gland is present (3.5 x2.0 x 1.5 cm) In additicn to that.four lymph nodes are identified ranging from 0.6 x0.4 x 03to 1.3 x0.8x0.8 cm. SECTION CCDE:A1.three lymph nodesA2,one lymph nodebisectedA3.representative sections of submandibular gand, B CONTENTS,LEFT SUPRAOMOHYODLEVEL1AIBAIBAND I-Received two irregular masses of adipose tissueaggregating 11.0 x 6.0 x 2.0 cm The specimen is oriented by the surgeon in the grcss room and separaed into the separate levels The adipose tissue is explored for lymph nodes A 24 x 1.5 cmgrassly positive lymph node is identifiec in level l. Multiple levels are identified in the other levels none of which are grossly positive. SECTION CODEB1four lymph nodes from level1"Ain entiretyB2,B3.a2.2x 1.7x 1.0 cm.grossly negative lymph nodes from evel I"B",serially sectioned and entirely submittedB4.three lymph nodes entirely submittedB5,two lymph nodes submitted entirelyB6.one lymph node submitted entirelyB7.two lymph nodes,entirely open level ll"A)B8.one lymph node in entirety (levell "A)B9two presumable lymph nodes from level IBB10.three levelIBlymph nodeB11 B13.the largest lymph node (2.4x 1.5 cm.serially sectioned and entirely submitted,B14,three lymph no four lymph nodes,entirelyB16,two lymph nodes,entirely.B17.five presumabe lymph nodes,entirely C POSTERIOR LEFT GP SULCUS -A 0.7 x 0.4 x 0.3 cm red-tan,unor ented soft tissue fragment. Submitted entirely in C for frozen section diagnosis. *FS/DX:SQUAMOUS MUCOSA.NO TUMOR PRESENT D LEFT BASF QF TONGUE-A 1.7 x 0.4 x 03 cm red-tan fragment ot soft tissue.Submitted entirely in D for frozen section diagnosis *FS/DX SQUAMOUS MUCOSA WITH SALIVARY GLANDS,NO TUMOR PRESENT E RIGHT GINGIVAL MARGIN-A2x 0.4 x0.2 cm red-tan fragment of soft tissue.Entirely submitted in E for frozen section diagnosis. FS/DX INVASIVE POORLYDIFFERENTIATEDCARCINOMA FRIGHT FLOR OF MOUTH-A 1.0 x 0.4 x 0.4 cm red-tan fragment of soft tissue Entirely submitted in F for frozen section dagnosis. FS/DXSQUAMOUS MUCOSA WITH SALIVARY GLANDS.NO TUMOR PRESENT. GANTERIO ABlAL MARGIN-A 1.7 x 0.4 x0.4 cm tan fragment.of soft tissue. Entirely submitted in G for frozen section diagnosis. *FS/DX:SQUAMOUS MUCOSA.NO TUMOR PRESENT. H ANTERlOR ORAL TONGUE-A 1.8 x0.4 x 0.4 cm fragment of red-tan sot tissue.Entire y submitted in H for froze section diagnosis. FS/DX:SQUAMOUS MUCOSA,NO TUMOR PRESENT COMPOSITE RESECTION LEFT HEMIMANDIBLE-A 7.5x 6.0 x 5.2 cm left hemimandibulectomy and glossectomy specimen with tongue 6.0 x 3.0 x 2.0cm Four anterior alveoli and four sosterior alveoli are identified An ulcerating spreading infiltrating mucosal tumor is identified involving the entire floor of the mouth.extending from anterior to posterior for 6.0 cmmedial to lateral along the floor of the routh and involving the base of the tongue for 3.0 cm and invading up to a maximum depthof2.0cm. The tumor invades the anterior mandible grossly. Cut sections are fleshy and yellow-white. SECTION CODE:1112,anterior most section of tumor with possible bone invas on13 and I4.one transverse section of tongue with mucosal tumor.entirelyl5-17.representative sections of tongue and floor of mouth mucosa,from medial oortion of resection to posterior portion of glossectomyl8.representative of tumor,and apparently normal gingival mucosa JRIGHTGINGIVAL MARGININFERIOR-Two nink-tanstrips2.0 x0.7 x0.3 cm and 1.0 x0.4 x0.2 cm SECTION CODE:J,entirely submitted FS/DXSQUAMOUS MUCOSA AND BONE,NO TUMOR PRESENT. Page2of4 Surgical Pathology Report File under Pathology
+
+--- Page 3 ---
+K RIGHT GINGlVAL MARGINA 0.9 x 0.3 x 0.2 cm pink-tan tissue fragment. The specimen is entirely submitted for frozen section LRIGHT MANDIBLE-A cross section of mandible 1.6x0.9x0.6 cm with a smaller fragment 0.9 x0.5 x0.3 cm.Central marrow identified.No definitive tumor is seen M TEETH-Seven intact teeth are received. Gross only CLINICAL HISTORY None given SNOMED CODES T-C42000.T-51004.T-53131T-51200.T-51100.T-11810.M-80703.M-80706M-00110 Scmeless tnnoredrere natnvr hee orove y the ts Fcodand ug Adminstratinn Released by Page 3 of4 Surgical Pathology Report File underPathology
+
+--- Page 4 ---
+ADDENDUM DIAGNOSIS I CCMPOSITE RESECTION LEFT HEMIMANDIBULECTOMY POORLY DIFFERENTIATED SQUAMOUS CARCINOMA INVADING BONE Bony margins of resection of mandible free cf tumor L} RIGHT MANDIBLE Bone no tumor. Entire report anddiagnosis completed by Released by Page4of4 Surgical Pathology Report File underPathology
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diff --git a/output/text/53cc0d6a-1c47-4996-ae06-52d6de2ab56b.txt b/output/text/53cc0d6a-1c47-4996-ae06-52d6de2ab56b.txt
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index 0000000000000000000000000000000000000000..23ce46aaf488de1379157de3046410d19a6ebaeb
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+UUID:EEF4E8C6-6D80-4C6A-BFC6-E529692088C1 TCGA-AC-A80S-01A-PR Redac tec  Referrina Phvsician: DOB: Age:: Gender:F Ref#: Hosp#: Provider Group : Date Received: Case # Date of Service: Room Date Reported: 1cD-O-3 FINAL SURGICAL PATHOLOGY REPORT 'orsinome insilttstire Diagnosis: LeuIor NoS 8520/3 Site Yuastnos Cso9 A. Left breast, pROphylAcTIc mastecTOmy: - Benign breast tissue with fibrocystic changes, including fibrosis, cysts,4 y/7/J) apocrine metaplasia, and sclerosing adenosis. - Three benign lymph nodes. - Unremarkable skin and nipple.. B. - D. RIGHT BREAST AND AXILLARY LYMPH NODE, MASTECTOMY WITH SENTINEL LYMPH NODE BIOPSY: - Multifocal invasive lobular carcinoma, Nottingham grade 2.. - Tumor size: 3 cm (largest nodule).. - Smaller nodules range from 0.1-0.6 cm in diameter and are located. in the vicinity of the larger nodule.. - Mastectomy margins are free of tumor. - Invasive carcinoma is 0.3 cm from the anterior-superior margin, and is at. Ieast 1 cm from all other margins.. - Two benign lymph nodes, no tumor (0/2). - This includes one sentinet lymph node and one non-sentinel Iymph node.. -- Lobular carcinoma in situ (LCis), low nuclear grade.. - Portion of skeletal muscle (specimen D), comprising deep margin.. PATHOLOGIC TUMOR STAGING SYNOPSIS: Type and grade (invasive): Invasive lobular carcinoma, Nottingham grade 2. Type and grade (in situ): LCIS, low nuclear grade. Primary tumor: pT2(m). Regional Iymph nodes: pNo(i-)(sn). Distant metastasis: Not applicable. Stage: IIA. Lymphovascular invasion: Not seen. Margin status: Negative. Page 1 Case #: This report continues... (FINAL) Printed: MR No. Acct No. - Patient Name - ge 1 Doc#1  Pathology - Page 1/7
+
+--- Page 2 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT cOmmENT: Small tumor nodules (0.1 - 0.6 cm) are identified slightly anterior and inferior to the main tumor mass, which is 3 cm in diameter. Invasive Breast Cancer Tumor Staging Information. AJCC Cancer Staging Handbook, 7th Ed., and CAP Protocol (revised June 2012) Previous pathology specimens: Page 2 Case #: This report continues... (FINAL). Printed: MR No. Pathology - Page 2/7 Page 2 Doc# 1
+
+--- Page 3 ---
+Patient: Case #: SPECIMEN IDENTIFICATION Procedure/specimen type: Mastectomy. Right. Laterality: Lymph node sampling: Sentinel lymph node biopsy. INVASIVE CARCINOMA TUMOR CHARACTERISTICS Histologic type: Invasive lobuiar carcinoma. Tumor site: Upper outer quadrant. Tumor size: 3 cm (largest nodule). Tumor focality: Multifocal. 2 of 3. Histologic grade (Nottingham Score): Tubule formation: 3 0f 3. 2 of 3. Nuclear pleomorphism: Mitotic rate: 1 of 3. Lymphovascular invasion: Not seen. Macroscopic and microscopic extent of tumor:. No skin or chest wall invasion identified. DUCTAL CARCINOMA IN SITU (DCIS): Not present. MARGINS  Invasive carcinoma: Negative. Ductal carcinoma in situ: Not applicable. LYMPH NODES Total lymph nodes examined 2. Number of lymph nodes involved 0. PATHOLOGIC STAGING: Primary Tumor (pT): pT2(m). Regional lymph nodes (pN): pN0(i-)(sn). Distant metastasis (pM): N/A. IIA. AJCC Stage: ANCILLARY STUDIES: Performed on previous core needle biopsy. Estrogen receptor: 100% positive cells, strong intensity. Progesterone receptor: 4% positive cells, weak intensity. HER2: IHC score 1+. Ki-67: 12% positive cells. Page 3 Case #: This report continues... (FINAL) Printed: MR - Page 3 Doc# 1 Pathology - Page 3/7
+
+--- Page 4 ---
+Datiant. Case #: FINAL SURGICAL PATHOLOGY REPORT Source of Specimen: A. Breast total mastectomy;Left B. Sentinel lymph node;Right C. Breast total mastectomy;Right D. Breast surgical;Posterior to tumor right breast Clinical History/Operative Dx: Breast cancer. Intraoperative Diagnosis: B. Right sentinel node : Negative for tumor. D. Posterior to tumor, right breast, Fs: Benign skeletal muscle, negative for tumor The intraoperative interpretation(s) was/were performed and rendered a Gross Description: A. Received in formalin labeled "left breast with stitch at medial side." Sutures present for orientation purposes: Stitch at medial apex of breast. Laterality: Left. Specimen: Mastectomy. Size of mastectomy: (M-L x S-I x A-P): 213 x 26.1 x 3.8 cm. Axillary tail: N/A Skin: 18.0 x 10.1 cm. Nipple/areola: Present. Specimen weight: 741 grams. Ink code: Blue -- superior-anterior, orange. -- inferior-anterior, black - deep Slabs: Total #13, M=13 , L=1. Nipple in slabs #9-10 Time of resection: Time placed into formalin: Page 4 Case #: This report continues... (FINAL) Printed: MR No. - Acct No. . Patient Name - - Page 4 Doc# 1 Pathology - Page 4/7
+
+--- Page 5 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT Time out of formalin:  Non-lesional breast: The cut sections of the breast demonstrates rubbery to indurated, pink and tan parenchyma and admixed yellow-tan fibroadipose tissue. There are marked areas of induration in the upper outer quadrant, however, no distinct mass lesion is appreciated. In slab 3 of the upper outer  quadrant are three lymph nodes ranging from 0.5 cm to 1.2 x 0.8 cm each. Representative sections are submitted. Cassette summary: A1) nipple,. A2) medial and lateral extension of skin, A3) slab 1, upper outer, A4) slab 3, larger lymph node, bisected, A5) slab 3, two smaller nodes, one bisected (orange),. A6) slab 5, upper outer quadrant, indurated changes, over an area of 5.5 cm, A7-A8)) slab 7, upper outer quadrant, including superior superficial surgical margin, A9) slabs 8-9, central breast parenchyma, A10) slab 11, upper inner quadrant, A11) slab 12, lower inner quadrant. A12) slab 4, lower outer quadrant. B. Part B is designated as right sentinel node. . Initially received in the fresh state for frozen. section/touch prep analysis is a 2.0 x 2.0 x 1.0 cm portion of pink and yellow-tan fatty sott tissue. Sectioning reveals a single, 2 cm fatty lymph node. Two touch imprint slides are forwarded for microscopic evaluation. The lymph node is entirely submitted in B1 and B2 with a sentinel node protocol performed. Time of resection:. Time submitted in formalin:. C. Part C is right breast. Initially received in the fresh state for possible Oncogenotyping studies/tumor bank harvest designated as right breast. Sutures present for orientation purposes: Double long suture marks medial apex of skin, per Laterality: Right. Specimen: Mastectomy. Size of mastectomy: (M-L x S-I x A-P): 20.8 x 18.3 x 6.3 cm. Axillary tail: N/A Skin: Overying skin is 18.0 x 8.4 cm.  Nipple/areola: Present. Specimen weight: 716 grams. Ink code: Orange -- superior-anterior, blue -- inferior-anterior, black -- posterior. Slabs: Total #13 , M= 13, L=1. Nipple in slabs #7-8. Time of resection: Page 5 Case #: This report continues... (FINAL). Printed: MR No. Page 5 Doc# 1 Pathology - Page 5/7
+
+--- Page 6 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT Time placed into formalin: Approximately Time out of formalin:  Lesion 1: Biopsy site: Yes, hook and spring-shaped metallic radiologic marker embedded within lesion (slab #5). Size: 3.0 x 2.8 x 2.4 cm, poorly demarcated admixed yellow and tan-white.. Location: Upper outer quadrant.  Involves slabs # 4-7. Distance to nearest margin(s): 0.3 cm from deep, 1.8 cm from superior-superficial, greater than 5 cm from the inferior-superficial, most lateral and most medial surgical margins.. Lesion #2: Biopsy site: No. Size: Up to 0.6 x 0.5 x 0.4 cm, poory defined, yellow-gray. Location: 0.9 cm anterior to large mass.  Involves slab #5. Distance to nearest margin(s): 2.3 cm from deep, 1.8 cm from superior-superficial.. Lesion #3: Biopsy site: No. Size; Location: 0.6 cm anterior to lesion #1. Involves slab #5. Distance to nearest margin(s): 0.5 cm from superior-superficial, greater than 2.5 cm from the deep. Non-lesional breast: Remaining cut sections of the breast demonstrate pink, rubbery parenchyma centrally with transient, indurated, fibroadipose tissue in the lateral breast. Examination of the most lateral extension of breast reveals a single 0.6 x 0.5 x 0.4 cm lymph node (slab 2). Representative sections are submitted. Cassette summary: C1) nipple, C2) medial and lateral extension of skin, C3) slab 2, upper outer quadrant, adjacent to large mass, includes small lymph node,. C4-C5) slab 3, adjacent to large mass, C6) slab 4, upper outer quadrant, lesion, including deep margin, C7) slab 5, upper outer quadrant, C8) slab 5, tissue superior to large lesion, C9) slab 5, tissue medially inferior to large lesion, C10) slab 6, lesion #2, C11) slab 5, lesion #3 including superior superficial surgical margin, C12) slab 5, additional superior superficial surgical margin adjacent to lesions #1-3, two pieces, C13-C15) slab 6, 2.0 cm superior to lesion, lesion, tissue 2 cm inferior to lesion, ???????? C16) slab 7, possible medial edge of large mass, C17) slab 8, adjacent to large mass, upper outer quadrant, C18) slab 12, upper inner quadrant,. C19) slab 11, lower inner quadrant,. C20) slabs 7-8, central breast parenchyma, C21) slab 5, 6.5 to 8.0 cm inferior to large mass including inferior superficial surgical margin (blue), C22) slab 3, lower outer quadrant. Case #: Page 6 Printed: This report continues... (FINAL) Pathology - Page 6/7 - Page 6 Doc# 1
+
+--- Page 7 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT D. Part D is posterior to tumor, right breast (blue is old surface). Initially received in the fresh state for. frozen section evaluation is a 3.5 x 2.0 x 0.8 cm portion of red-tan soft tissue. The old surface has been previously marked blue, and is now re-inked blue. The new margin is now marked black. The specimen is serially sectioned revealing deep red skeletal muscle without gross tumor involvement. The tissue is. entirely submitted for frozen section evaluation with the residual frozen tissue submitted in D1-D3. Time of resection: Time submitted in formalin: Approximately Microscopic Description: A. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered. B. Immunohistochemical stain: CK OsCAR, showing no evidence of metastatic carcinoma.. C. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis. rendered. D. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered. Case # Printed: MR No.  Pathology - Page 7/7
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diff --git a/output/text/53e6a90d-ecdc-45dc-86b4-e6662ffa0982.txt b/output/text/53e6a90d-ecdc-45dc-86b4-e6662ffa0982.txt
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index 0000000000000000000000000000000000000000..6aba29a9fee394fe16effbbe86e0a551e15eb998
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+
+--- Page 1 ---
+E/txs8 BREAST TISSUE CHECKLIST Specimen type: Mastectomy 3 Specimen size: Not specified Tumor site: Breast Tumor size: 4.3 x 3 x 3 cm "//E Grossly evident lesion: Yes Histologic type: Infiltrating ductal and lobular carcinoma. Histologic grade: Tumor extent: Not specified. Lymph nodes: 0/9 positive for metastasis (Regional 0/9) Right, upper Extracapsular invasion of the lymph nodes: Not specified outer Margins: Not specified SON quadrant Nottingham Histologic Score fy Tubule formation: Not specified. eed -0-407 Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified. : y!S Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined. Evidence of neo-adjuvant treatment: Not specified. Additional pathologic findings: Not specified Comments..None.
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diff --git a/output/text/53f7cfdb-ef84-437a-a581-c3fd26b3cf08.txt b/output/text/53f7cfdb-ef84-437a-a581-c3fd26b3cf08.txt
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index 0000000000000000000000000000000000000000..d13e71ba23b9531ff6e5f4ef30ef9a8f9b4fde29
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID: 5885CEFD-CC07-4451-A774-25FB146067C7 TCGA-BH-A42V-01A-PR Redacted Collection Date: FINAL DIAGNOSIS: Part 1: SEntineL Lymph nOde #1, biOpsy - A. One lymph node wIth mIcrometastatic CArcinomA (1/1). B.  micro metastatic tumor measures 1 mm In greatest Dimension. C.  NO EXTRACAPSULAR EXTeNSION IS IDEnTiFieD. part 2: sentinel Lymph node #2, biopsy -- One lymph nODe, nEgative fOr tumor (0/1). Part 3: sentineL Lymph nOde #3, siOpsy - ONe Lymph nodE, NEgaTIVE fOR TumoR (0/1). Part 4: Left Breast, segmental. mastectomy at 4 O'clock - A  INfiLTratiNg Ductal CaRcinomA, 1.5 Cm IngReaTeSt DimensiOn AssOciateD wITH MICROCALCIFiCATIONS. B.  NOtTingham SCORE 6/9 (tubuLeS 2, nucLeaR gRADe 2, MITOtIc Act!vity 2), nOTTingham grADe 2). C.  NO LyMPHOVASCULAR INVASION iS IDENTIFIED. D. DUctAL CArCinOmA iN SItU, CRiBRIFORm TYpE, nUCLeAR GRaDE 2 WITH COmeDO-Type NECrOSIS AND ASSOCiATED MICROCALCIFICATIONS COMPRISING 3% OF INVASIVE TUMOR AND ALSO PRESENT iN THE SURrOUnDInG BREaSt TISSUE. E.  SURGICAL MARGINS ARE NEGATIVE FOR INFILTRATING DUCTAL CARCINOMA AND DUCTAL CARCINOMA IN SITU.  iNFILTRATING DUCTAL CARCINOMA IS FOCALLY PRESENT 3 MM AWAY FROM POSTERIOR MARGIN. F G.  DUCtal CArCiNOMA In SITU FOcALLy VERy CLOSeLy APPtOACHES SUPERiOR MArgIN 0.2 MM). H. ATYPICAL DUCTAL HYPERPLASIA.  PERIPHERAL PAPILLOMAS. J.  DUCTAL EPITHELiAL hYPERPLASIA AND COLUMNAR CELl CHAnGE. CASE SYNOPSIS: SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST LATERALITY: Left PROCEDURE: Segmental LOcATIOn: Clock position:4:00 Size Of TumOR: Maximum dimenslon invasive component: 15 mm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: No TUMOR TYPE (invasive component): Icd-o-3 Ductal adenocarcinoma, NOS Carcin ma,inFsHati ngy NOTTinghAm SCOre: Nuclear grade: 2 Tubule formation: 2 Cl ucta1, nus Mitotic activity score: 2 Total Nottingham score: 6 8 500J3 Nottingham grade (1, 2, 3): 2 Sik: breast,NOs ANGIOL YMPHATIC INVASION: DERMAL LYMPHATIC iNVASION: No Not appllcable CALCIFICATION: C 50.9 Yes, malignant zones 9-1-1z Tumor type, In situ: Cribriform RO Percent of tumor occupied by in situ component: 3 %  SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No Distance of invasive tumor to dlosest margin: 3 mm SURG MARGINS INVOLVED BY IN SITU COMPONENT:E No Distance of in situ disease to closest margin: 0.2 mm LYMPH NODES POSITIVE: 1 Lymph nODeS ExAmIneD: 3 mEThOD(S) Qf Lymph nODe ExAmInATiON: H/E stain  SENTINEL NODE METASTASIS:E Yes SIZE OF NODAL METASTASES: Diameter of largest lymph node metastasis: 1 mm LYMPH NODE METASTASIS(-ES) WITH EXTRACAPSULAR EXTENSION: No NOn-nEOPLASTIC BREAST TiSSUe: ADh, Papilloma, FCD t stage, PatholOgIC: pT1c N Stage, pathologic: pN1mi M STAGE: Not appllcable ESTROGEN RECEPTORS: positive PROgEsteRONE RECePTORS: positive HER2/NEU: 1+
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diff --git a/output/text/54053f7d-be91-4e6f-ba00-736a3b5b4e04.txt b/output/text/54053f7d-be91-4e6f-ba00-736a3b5b4e04.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a5520d3f90829a64ab365a4c6d5f1283f91e6a6a
--- /dev/null
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+--- Page 1 ---
+1cO-0-3 Carcinoma,vnfi1tnaHg cucH1, No5 8500/3 Sits; braot,NOs c50.9 127/11 Name: Age/Sex: Location: Acct#: Unit#: 'Status: DIS IN  Room/Bed: Reg: Disch: Att Dr: deletions Any previous versions are stored intarnally and are.available Specimen: Received: Status: Req#: Spec Type: SURGICAL P Subm Dr: PPEOPERATIVE DIAGNOSTS LEFT BREAST CANCER INVASIVE, BREAST ASYMMETRY (PHRATION PERHORMED DATE : DOCTOR(S) : PROCEDURE :  LEFT SIMPLE MASTECTOMY, SENTINEL NODE BX, : REDUCTION. MAMMOPLASTY PROCEDURE (CONT) : BREAST RECONSTRUCTIN WITH TISSUE EXPANDER: A. LEFT BREAST MASTECTOMY B. LT BREAST 1ST SENTINEL NODE UUID: BC75790C-FBC7-4897-B228-762245C487400 c. LT BREAST 2ND SENTINEL NODE TCGA-A2-A0SU-01A-PR Redacted D. LT BREAST 3RD SENTINEL NODE E. LEFT BREAST TISSUE F. RIGHT BREAST TISSUE PART A RECEIVED FRESH LABELED LEFT BREAST MASTECTOMY STITCH AT SUPERIOR MEDIAL BORDER, IS A LEFT SIMPLE MASTECTOMY SPECIMEN AS ORIENTED BY A SUTURE MEASURING 21 X 20 X 4.5 CM. A SKIN ELLIPSE MEASURES 11.2 X 6.5 CM, WITH A GROSSLY UNREMARKABLE NIPPLE. THE SUPERFICIAL ASPECT IS MARKED IN BLUE INK, THE DEEP ASPECT IN BLACK INK. IN THE MIDPORTION, THERE IS A 0.9 X 0.7 X 0.9-CM LESION 2.5 CM FROM THE DEEP MARGIN. A PORTION OF THIS IS SUBMITTED PER PROTOCOL, THE MIRROR IMAGE IS SUBMITTED IN A1, AND THE CORRESPONDING DEEP MARGIN IN A2. A SECOND LARGER LESION IS FOUND LATERAL TO THIS MEASURING 2.2 X 1.6 X 1.5 CM.  THIS IS 2 CM FROM THE DEEP MARGIN. THIS DEEP MARGIN IS SUBMITTED IN A3. THESE TWO AREAS ARE 1.5 CM APART. MEDIAL TO ALL OF THESE IS A SMALL SUPERFICIAL LESION, O.5 CM IN GREATEST DIMENSION, 2.5 CM FROM THE FIRST DESCRIBED LESION. THIS LESION IS SUBMITTED IN A6. AS REPRESENTS A SECOND SECTION OF THE LARGEST MOST LATERAL LESION. THE SMALLEST LESION IS 4 CM FROM THE DEEP MARGIN, WHICH IS SUBMITTED IN A7. THE REMAINING BREAST TISSUE CONSISTS OF BLAND YELLOW FATTY TISSUE WITH FINE FIBROUS BANDS. ADDITIONAL SECTIONS OF THE BREAST TISSUE ARE SUBMITTED AS FOLLOWS:  A8--UPPER OUTER QUADRANT, A9--UPPER INNER QUADRANT, A1O--LOWER INNER QUADRANT, A11--LOWER OUTER QUADRANT, A12--NIPPLE. THE LARGEST LESION IS SUPERIOR TO THE NIPPLE, AND
+
+--- Page 2 ---
+Patient: (Continued) Specimen: Received: Status: Req#  Spec Type: SURGICAL P Subm Dr: (Continued) THESE LESIONS PROGRESS THEREFORE IN THE UPPER INNER QUADRANT OF THE BREAST. PART B RECEIVED FRESH LABELED  LEFT BREAST FIRST SENTINEL NODE HOT, IS A PORTION OF YELLOW FATTY TISSUE MEASURING 2.2 X 1.6 X O.1 CM. SECTIONING REVEALS A O.7-CM LYMPH NODE.  ONE-HALF IS SUBMITTED PER PROTOCOL; THE REMAINDER IS SUBMITTED LABELED B.S PART C RECEIVED FRESH LABELED LEFT BREAST SECOND SENTINEL NODE HOT, IS YELLOW FATTY TISSUE MEASURING 3.8 X 1.1 X O.8 CM. EXAMINATION REVEALS A 2.2 CM IN LENGTH GROSSLY UNREMARKABLE LYMPH NODE, PORTION OF WHICH IS SUBMITTED PER PROTOCOL, AND THE REMAINDER IS SUBMITTED A LABELED C. PART D RECEIVED FRESH LABELED THIRD SENTINEL NODE, IS AN OVOID PORTION OF YELLOW FATTY TISSUE MEASURING 2.5 X 1.2 X 1.0 CM. SECTIONING REVEALS FIRM TISSUE BUT NO GROSS NODAL TISSUE. A PORTION IS SUBMITTED PER PROTOCOL, AND THE REMAINDER IS SUBMITTED LABELED D. PART E RECEIVED LABELED  SECOND BREAST TISSUE SUPERFICIALLY OVER SUPERIOR MEDIAL ASPECT OVER HARD NODULE STITCH AT NEW MARGIN, IS AN IRREGULAR PORTION OF YELLOW FATTY TISSUE MEASURING 2.9 X 2.0 X O.5 CM. A SUTURE DENOTES A NEW MARGIN, AND THIS SIDE IS MARKED WITH INK. THIS IS SECTIONED AND SUBMITTED LABELED E. PART F RECEIVED LABELED  RIGHT BREAST TISSUE, IS 256 GRAMS OF FIBROFATTY BREAST TISSUE AND SKIN.  SECTIONING REVEALS BLAND YELLOW FATTY TISSUE WITH FINE FIBROUS BANDS.  THERE ARE NO AREAS OF BROAD FIBROSIS OR MASSES IDENTIFIED. REPRESENTATIVE TISSUE IS SUBMITTED LABELED F1 THROUGH 5. PROCEDURES : 88305, 88307/5, IMMUNOPEROXIDAS/3, A1 BLK, A10 BLK, A11 BLK, A12 BLK, A2 BLK, A3 BLK, A4 BLK, A5 BLK, A6 BLK, A7 BLK, A8 BLK, A9 BLK, BBX X6, CBX X6, DBX X6, E1 BLK, Fl BLK, F2 BLK, F3 BLK, F4 BLK, F5 BLK PART A LEFT BREAST, SIMPLE MASTECTOMY: 1. MULTICENTRIC MODERATELY DIFFERENTIATED INTRADUCTAL AND INFILTRATING DUCT CARCINCMAS (3), NUCLEAR GRADE 2 WITH MODERATE MITOTIC INDEX WITH AN INSITU COMPONENT OF 5-1O% OF SOLID AND CRIBRIFORM TYPE
+
+--- Page 3 ---
+Patient (Continued) Specimen: Received: Status: Req#: Spec Type: SURGICAL P Subm Dr: (Continued) 2. THREE TUMORS MEASURING 2.2, 1.0 AND 1.0 CM ARE PRESENT WITH ONE TUMOR INVOLVING THE SUPERFICIAL MARGIN. 3. DUCTAI CARCINOMA IN SIIU IS PRESENT IN THE DEEP DUCTS OF THE NIPPLE SKIN. THE NIPPLE SKIN AND DEEP MARGINS OF EXCISION ARE FREE OF NEOPLASM. 4. FOCI SUSPICIOUS FOR LYMPHATIC INVASION ARE PRESENT. PART B LEFT BREAST, FIRST SENTINEL NODE, BIOSPY: LYMPH NODE (1) WITH AN ISOLATED FOCUS OF TUMOR CELLS, MEASURING O.O1 MM, INDENTIFIED ON THE CYTOKERATIN STAIN AND ONLY THE FIRST OF THREE STEP-SECTIONS OF THE H&E STAINS. PART C LEFT BREAST, SECOND SENTINEL NODE, BIOPSY: LYMPH NODE (I), NEGATIVE FOR TUMOR BY ROUTINE AND CYTOKERATIN STAIN. PART D LEFT BREAST, THIRD SENTINEL NODE, BIOPSY: SMALL LYMPH NODES (5), NEGATIVE FOR TUMOR BY ROUTINE AND CYTOKERATIN STAIN. PART E LEFT BREAST SUPERFICIAL TISSUE RE-EXCSION: FIBROADIPOSE TISSUE, NEGATIVE FOR TUMOR WITH THE NEW INKED MARGIN FREE OF NEOPLASM. PART F RIGHT BREAST, REDUCTION MAMMOPLASTY: SKIN, ADIPOSE AND BREAST TISSUE WITH FIBROCYSTIC CHANGE AND A FOCUS OF ATYPICAL LOBULAR HYPERPLASIA. ONCOTYPE RESULTS: CLINICAL EXPERIENCE:  PATIENTS WITH A RECURRENCE SCORE OF 14 IN THE CLINICAL VALIDATIONS STUDY HAD AN AVERAGE RATE OF DISTANT RECURRENCE AT 10 YEARS OF 9%(95% CI: 6%-12%). Signed (signature on file).
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diff --git a/output/text/5419c07a-d539-4cd5-8eac-c4f12da274e0.txt b/output/text/5419c07a-d539-4cd5-8eac-c4f12da274e0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2c7a1c31f9312845d995b375e96bb0ae6108c7d3
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+
+--- Page 1 ---
+/cD-0-3 Poth Srts:brst, LOQ C50.5 1/05 CQcF Sits: 1rsst, Nos c50.9. Diagnosis: 4. Resected material from Ieft breast segment with a 1.4 cm poorly differentiated (G3)  invasive ductal breast carcinoma. Carcinoma-free resection margins, carcinoma-free skin. Fibrous mastopathy of surrounding tissue.. Tumor stage: pT1c pN1mi (intranodal micrometastasis), MX, R0; G3 (L0, V0). Redacted TCGA-A8-A09K-01A-PR
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diff --git a/output/text/54210b67-42a8-47ac-9c3e-5b3e6be10819.txt b/output/text/54210b67-42a8-47ac-9c3e-5b3e6be10819.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3d8a8f55fb8b212fbb024dfce75915dca765ae32
--- /dev/null
+++ b/output/text/54210b67-42a8-47ac-9c3e-5b3e6be10819.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+E#1, Biopsy  PLASM (0/1) (see comment). DE #2, BIOPSY -- SOPLASM (0/1). PART 3R StOmy aT 11 O'ClOCK - A INEKIRAT MA, NOTTINGHAM GRADE 3/3 (TUBULE SCORE 3, NUCLEAR GRADE 3, MITOSIS SCe SCORE 9/9) (see comment). B. ALL MARGINS ARE NEGATIVE FOR NEOPLASM. C. D.  DEFINITE ANGIOLYMPHATIC INVASION IS NOT IDENTIFIED. E. Biopsy Site changes. F. HyPERPLASIA (PASH). CASE SYNOPSIS: SYNOPTIC - PRIMARY iNVASIVE CARCINOMA OF BREAST LAteraLity: PROCEDURE: Right LOcATION:  Segmental SIZE Of TUmOR: Upper outer quadrant MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:  Maximum dimension invasive component: 1.3 cm TUMOR TYPE (invasive component): No  NOTTINGHAM SCORE: Ductal adenocarcinoma, NOS 1ch-0-3 Nuclear grade: 3 Tubule formation: 3 Chcninn, nifiltnsHng out, nos 8500/3 Mitotic activity score: 3 Total Nottingham score: 9 ANGIOLYMPHATIC INVASION: Nottingham grade (1, 2, 3): 3 DERMAL LYMPHATIC INVASION: No CALCIFICATION: Not applicable SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:E No No Lymph nODes PosITive: Distance of invasive tumor to closest margin: 8 mm LYMPH NODES EXAMINED: 0 METHOD(S) OF LYMPH NODE EXAMINATION: 2 SENTINEL NODE METASTASIS: H/E stain, Keratin stain NON-NEOPLASTIC BREAST TISSUE: FCD, Other: co!umnar cell change and PASH No t Stage, pathologiC: N Stage, pathOlOgIC: pT1c m Stage, pathologic: pN0 EsTrOgen recepTOrS: pMX PROGESTERONE RECEPTORS: unknown HER2/NEU: unknown unknown UUID:00647293-3CEA-4845-A0B3-D7000CBA84C0 Redacted TCGA-BH-A0BL-01A-PR
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diff --git a/output/text/547c1c92-00d5-49c0-b796-6e3ec19c97b1.txt b/output/text/547c1c92-00d5-49c0-b796-6e3ec19c97b1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ebc6ed10fe730b33b4435d83e128c1eb36498aac
--- /dev/null
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+
+--- Page 1 ---
+IcD-6 3 'arcinonw, inyislraleroycluct 0 8$d613 Nos UUID: BE19CEFA-7A66-480C-BEC0-AF52F4C8A04C Site O Yuast NS TCGA-A7-A6VW-01A-PR Redacted C56.9 OtJ 7|zs/l3 Final Surgical Pathology Report Procedure: Diagnosis A. Sentinel lymph node, left axilla, biopsy: Two negative lymph nodes (0/2). B. Breast, left, excisional biopsy: Invasive ductal carcinoma, grade 3, size 3.0 cm in greatest dimension, close to the medial and inferior margins. Microscopic Description: Invasive carcinoma: Histologic type:  Ductal Histologic grade: 3 Overall grade: 9/9 Architectural score: 3 Nuclear score: 3 Mitotic score: Greatest dimension (pT2): Size 3.0 cm in greatest dimension Specimen margins: Carcinoma is well-demarcated, and forms a discrete mass lesion that is less than 1 mm from the medial margin and 0.5 mm from the inferior margin. Vessel invasion: Not identified Ductal carcinoma in situ: Not identified. Comment: Prior biopsy site identified.. Distant metastasis (pM): Unknown Lymph nodes: Two negative sentinel lymph nodes, 0/2. Prognostic markers: See previous core biopsy Specimen A. Left axillary sentinel node B. Left breast biopsy clinical Information Left breast cancer, yo BF with grade 3 IDC Gross Description A. Received unfixed, labeled left axillary sentinel node, are two lymph nodes, the larger of which is 1.4 x 1.2 x 1.0 cm, bisected and submitted in blocks 1-2, and an additional node, 1.0 x 0.5 x 0.5 cm, bisected and submitted in block 3. B. Received unfixed in a : container, labesed left breast, is a portion of fibrofatty tissue that is oriented and 6.0 cm anterior to posterior, 4.5 cm medial to lateral, and 2.3 cm superior to inferior.  Margins are inked:. inferior blue, superior black, medial yellow, lateral green. The specimen is serially sectioned from anterior to posterior. There is a 3.0 x 2.0 x 1.9 cm tumor present, adjacent to the medial and inferior margins. Representative sections, including the anterior and posterior shave margins, sequentially submitted in 8 blocks.
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diff --git a/output/text/549929f9-d1ab-4ac8-ad82-cdb20621b6ac.txt b/output/text/549929f9-d1ab-4ac8-ad82-cdb20621b6ac.txt
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index 0000000000000000000000000000000000000000..0db88e8784f7706ce349cd8d013dccd41932a2f3
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+
+--- Page 1 ---
+UUID:E8D243F6-1508-4BDD-A2D4-58E23D8120F00 TCGA-GU-A42P-01A-PR Redacted Results BIOPSY OR S Patient Information Patient Name. Sex DOB Result Information Status Provider Status Final result  Reviewed Entry Date Component Results Component Lab Surgical Pathology Patient Name MR# icD-o-3 Specime Ca scinoma,unhe\ia1,NO5 Final Diagnosis 81a0)3 A. Right ureter, biopsy: Sik: bladcer,wa1i,Nos -Segment of benign ureter, negative for tumor. -Frozen section diagnosis confirmed C67.9 B. Left ureter, biopsy: 8-27.12 -Segment of benign ureter, negative for tumor. -Frozen section diagnosis confirmed. C. Left external and interna! lymph nodes, resection:. -Benign fibrovascular tissue, negative for tumor. -No lymph nodes identified D. Left internal and external iliac lymph node, resection:. -Single lymph node with metastatic urothelial carcinoma, 1.8 cm largest diameter (1/1) E. Left internal and external iliac lymph nodes, resection:. -Eight benign lymph nodes and fibroadipose tissue, negative for tumor (0/8). F. Left obturator lymph node, resection: -Three benign lymph nodes and fibroadipose tissue, negative for tumor (0/3). G. Left common iliac lymph, resection: -One benign lymph nodes and fibroadipose tissue, negative for tumor (0/1) H. Right internal and external iliac node, resection: -One benign iymph nodes and fibroadipose tissue, negative for tumor (0/1) I. Right obturator lymph node, resection: -Benign fibroadipose tissue, negative for tumor. -No lymph nodes identified F J. Urinary bladder and prostate, radical cystoprostatectomy:. -Invasive high grade urothelial carcinoma with glandular, micropapillary and. sarcomatoid differentiation, 4.0 cm. involving bladder diverticulum -Tumor invades into perivesicle tissue (pT3a) Page 1 of 8
+
+--- Page 2 ---
+-Surgical resection margins are negative for tumor. -Incidental prostatic adenocarcinoma, Gleason grade 3+3=6, organ confined (pT2a) and negative surgical margins. -See CAP cancer template for further details. Specimen Bladder and prostate Procedure Radical cystoprostatectomy Tumor Site Left lateral wall with involvement of diverticulum and extension to posterior  wall, right lateral, anterior walls and prostatic urethra. Tumor Size Greatest dimension: 4.0 cm Additional dimensions: 4.0 x 3.0 cm. Histologic Type Urothelial (transitional cell) carcinoma with glandular, micropapillary and sarcomatoid differentiation Associated Epithelial Lesions None identified Histologic Grade High grade Tumor Configuration Ulcerated Microscopic Tumor Extension Perivesical fat Margins Margins uninvolved by invasive carcinoma. Lymph-Vascular Invasion Present, extensive Pathologic Staging (pTNM) Primary Tumor (pT) pT3a: Tumor invades perivesicle fat, microscopic. Regional Lymph Nodes (pN) pN1:  Single regional lymph node metastasis in the true pelvis (hypogastric obturator, external iliac or presacral lymph node) Specify:  Number examined: 14 (see specimens C through I) Number involved (any size): 1 Distant Metastasis (pM) Not applicable Additional Pathologic Findings Evidence of previous biopsy  Incidental adenocarcinoma of prostate (see CAP template below) Ancillary Studies: Block J18 has been sent for ancillary studies, see separate report Page 2 of 8
+
+--- Page 3 ---
+CAP cancer template for prostate cancer: Procedure Radical cystoprostatectomy Prostate Size Weight: Not applicable (part of bigger specimen) Size: 3.7 x 5.3 x 1.3 cm Lymph Node Sampling Pelvic lymph node dissection (see specimens C through I) Histologic Type Adenocarcinoma (acinar, not otherwise specified) Histologic Grade Gleason Pattern Primary Pattern: Grade 3 Secondary Pattern: Grade 3 Tertiary Pattern: Not applicable. Total Gleason Score: 6 Tumor Quantitation Proportion (percentage) of prostate involved by tumor: 1% Extraprostatic Extension Not identified Seminal Vesicle Invasion Not identified Margins  Margins uninvolved by invasive carcinoma. Treatment Effect on Carcinoma: Not identified Lymph-Vascular Invasion Not identified Perineural Invasion Not identified Pathologic Staging (pTNM) Primary Tumor (pT) pT2a:  Unilateral, involving one-half of 1 side or less (left side) Regional Lymph Nodes (pN) pNO:  No regional lymph node metastasis Specify: Number examined: 14 (see specimens C through I) Number involved: 0 Distant Metastasis (pM) Not applicable Additional Pathologic Findings:. High grade prostate intraepithelial neoplasm Ancillary Studies: Block J28 can be sent for ancillary studies if needed. K. Appendix, appendectomy: Benign appendix without significant histopathologic abnormality Page 3 of 8
+
+--- Page 4 ---
+L. Left obturator, resection: -Benign fibroadipose tissue, negative for tumor -No lymph nodes identified The above pathology diagnosis incorporates data elements as outlined in the CAP Cancer Protocols and Checklists which are based on the AJCC/UICC TNM, 7th edition. Clinical History Bladder cancer. Radical cystectomy, lymph node dissection, ileal neobladder, possible ileal conduit, all other indicated procedures.. Source: A: Right ureter. B: Left ureter C: Left external and internal Lymph node. D: Left internal and external iliac Lymph node E: Left internal and external iliac lymph nodes F: Left obturator lymph nodes. G: Left common iliac lymph nodes. H: Right internal and external iliac lymph nodes I: Right obturator lymph nodes. J: Bladder and prostate K: Appendix L: Left obturator Gross Description Specimen A, received fresh labeled with the patient's name and designated 'right ureter, silk suture distai end' is a tubular segment of tissue 1.2 cm in length and 0.5 cm in diameter. The proximal margin is submitted for frozen section diagnosis as A1. Specimen B, received fresh labeled with the patient's name and designated 'left ureter, chromic stitch distal end' is a tubular segment of tissue 1.3 cm in length and 0.5 cm in diameter. The proximal margin is submitted for frozen section diagnosis as B1. Specimen C, received fresh labeled with the patient's name and designated 'left external and internal lymph nodes' is a 4.5 x 1.0 x 0.4 cm portion of adipose tissue. There is a 1.0 x 0.8 x 0.6 cm with a possible 1.0 x 0.8 x 0.6 cm lymph node. The node is submitted entirely for frozen section as C1. Specimen D, received fresh labeled with the patient's name and designated 'left internal and external iliac lymph node' is a 1.8 x 1.5 x 1.2 cm tan node. The cut surface is tan slightly bulging firm parenchyma. A section is submitted for frozen section diagnosis. Section key: The specimen is submitted entirely as follows: D1 - frozen section D2 - remainder of nodule Paae 4 of 8
+
+--- Page 5 ---
+Specimen E, received in formalin labeled with the patient's name and designated 'teft internal and external iliac lymph node' is 3.3 x 3.5 x 1.0 cm of fragmented fibrofatty tissue. There are seven possible nodes, 0.5 cm-1.0 cm. The nodes are submitted entirely as follows:. E1 - four whole nodes E2 - two nodes, one inked blue and each bisected E3 - one node, bisected Specimen F, received in formalin labeled with the patient's name and designated 'left obturator lymph node' is 3.3 x 3.0 x 1.0 cm of fragmented fibrofatty tissue. There are three possible nodes, 0.5cm-1.5 x 0.8 x 0.5 cm. The nodes are submitted entirely as follows: F1 - two nodes, one inked blue and each bisected F2 - one node, bisected Specimen G, received in formalin labeled with the patient's name and designated 'left common iliac lymph node' is a 2.0 x 1.0 x 1.0 cm portion of adipose tissue. There is a 1.2 x 0.8 x 0.8 cm tan node. The node is bisected and submitted entirely as G1. Specimen H, received in formalin labeled with the patient's name and designated 'right internal and external iliac lymph node' is 4.0 x 3.0 x 1.0 cm of fibrofatty tissue. Sectioning into this specimen shows approximately one-half. of the specimen as muscle fibers. There is one possible node, 2.0 x 0.6 x 0.4 cm. The node and representative muscle with fibrous tissue submitted as follows: H1 - one node, bisected H2 - muscle with white fibrous tissue. Specimen i, received in formalin labeled with the patient's name and designated 'right obturator lymph node' is 1.8 x 1.5 x 0.8 cm of fibrofatty tissue and muscle. A discrete lymph node is not identified. The specimen is submitted entirely as 11. Specimen J: Type of specimen: Urinary bladder, ureter stumps, prostate, and seminal vesicles The patient's name and case number on the specimen container match the accompanying paperwork and cassettes. Procedure: Radical cystoprostatectomy Fixative: Formalin Dimensions: Bladder 4.3 cm dome to neck x 4.2 cm left to right x 3.5 cm anterior to posterior; ureter stumps, right 3.5 cm in length and 0.4 cm in diameter; left ureter 3.8 cm in length and 0.4 cm in diameter; prostate 3.7 cm apex to base, 5.3 cm left to right, 1.3 cm anterior to posterior Description of findings: Tumor: There is an ulcerated, focally fluffy tan to brown mass, 4.0 cm dome to neck x 4.0 cm left to right x 3.0 cm anterior to posterior. The mass is on the posterior wall extending into the anterior, right and left wall. There is a diverticulum in the left bladder extending to a depth of 2.0 cm, with mass invading into the wall and to within 0.2 cm of the perivesicular adipose tissue (J17-J18). Involvement of important adjacencies: The tumor possible invades into the perivesicular adipose tissue, with no other structures involved. Uninvolved mucosa: Tan and focally edematous in the right dome Prostate, seminal vesicles and vasa deferentia: The prostate is sectioned apex to base into six slabs. The parenchyma is tan, with pale foci and no discrete mass. Ink code: Right prostate - orange Left prostate - blue. Anterior bladder - green Page 5 of 8
+
+--- Page 6 ---
+Posterior bladder - black Section key: J1 - urethral margin J2 - bladder neck right J3 - bladder neck left J4 - right uretal orifice, blue ink on ureter J5 - left uretal orifice, blue ink on ureter J6-J8 - tumor posterior wall, each full thickness section J9-J10 tumor right wall, each full thickness section J12-J13 - tumor left diverticulum, each full thickness sections J14-J15 - tumor left wall, full thickness sections J16 tumor left diverticulum. J17-J18 - tumor left diverticulum to within 0.2 cm of perivesicular adipose. tissue J19-J20 - tumor anterior wall. J21 - prostate right seminal vesicle - prostatic interface, vas deferens J22 - slab 1, apex prostate J23 - slab 3, right posterior prostate J24 - slab 6, right posterior prostate J25 - prostate left seminal vesicle - prostatic interface, vas deferens J26 - slab 1, left apex prostate J27 - slab 2, left posterior prostate j28 - slab 6, ieft posterior prostate Specimen K, received in formalin labeled with the patient's name and designated 'appendix' is a vermiform appendix with mesoappendix. The appendix is 7.7 cm in length and 0.5 cm in diameter. The mesoappendix is 9.0 x 2.4 x 0.8 cm. The appendiceal serosa is tan, smooth and glistening. The lumen ranges from 0.1 cm to 0.2 cm and is filled with brown fecal material. At the distal tip there is a pocket of fecal material, with unremarkable mucosa. Representative sections are. submitted, with the proximal margin inked blue as K1. Specimen L, received in formalin labeled with the patient's name and designated. 'left obturator' is a 2.3 x 1.5 x 0.6 cm portion of fibrofatty tissue with muscle, with multiple staples and sutures. The specimen is vascular without a discrete mass or lymph node. The specimen is submitted entirely as L1. Microscopic Description The H and E stain quality is acceptable. A-J. The microscopic findings are reflected in the diagnoses rendered. Intraoperative Diagnosis. Time in: Time out: A1-FS, Right ureter: Negative for carcinoma or high grade dysplasia. Time in: 'ime out: B1-FS, Left ureter: Negative for carcinoma or high grade dysplasia. Time in: ne out: C1-FS, Left external and internal lymph node, peripheral nerves and fibrovascular tissue with inflammation, negative for carcinoma.. Time in: Time out: D1-FS, Left internal and external iliac lymph node: Positive for metastatic carcinoma. All Reported to Paae 6 of 8
+
+--- Page 7 ---
+***Electronicallv Signed Out*** Result History BIOPSY OR SURGICAL SPECIMEN  it. Collection Information Specimen Source Date and Time Accession # Other Lab Information Reviewed by List Status: This order is currently not shared in . Order Biopsy or Surgical Specimen. Patient Information Patient Name Sex DOB Visit Information. Date Time Department Provider Visit # FIN # Order Information Order Date and Time Ordering User Department Order Order Name Code Order Number Biopsy or Surgical Specimen. Order Details Frequency Duration  Priority Order Class ONE TIME ORDER TASK 1 Occurrence Routine Nurse Collect Order Providers Authorizing Provider Encounter Provider Page 7 of 8
+
+--- Page 8 ---
+Original Order Ordered On Ordered By Collection Information Specimen Source Date and Time Accession # Other Reprint Requisition  Reprint Reguisition ( Page 8 of 8
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diff --git a/output/text/54a07a51-b200-4b95-a665-6d1ebd18aafd.txt b/output/text/54a07a51-b200-4b95-a665-6d1ebd18aafd.txt
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index 0000000000000000000000000000000000000000..1adfe25cb04784c7d436a4c4e05b2d50338578f2
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+
+--- Page 1 ---
+Encounter Date: UUID:DE5B5338-18C3-44AA-A88E-ADFC18EA5C87 Redacted A30F-01A-PR SURGICAL PATHOLOGY (Ord er Patient Name Sex DOB Results 1cp-o-3 Carcinoma, wro#elia1, NOS Specimen #: Submitting Physician: sik: bladder,antcnoy wuf 7.29.12 RO CLe7.3 FINAL DIAGNOSIS 1. Right distal ureter, biopsy (A) - Benign ureter, negative for neoplasm. 2. Left distal ureter, biopsy (B) - Benign ureter, negative for neoplasm. 3. Urinary bladder, radical cystoprostatectomy (c) - Invasive high-grade papillary urothelial carcinoma, 4.2 cm. -The tumor invades through muscularis mucosa (lamina propria) and deeply involves the perivesical fat. - Extensive lymphovascular invasion present.. - Bilateral ureteral, urethral and soft tissue resection margins are negative for tumor.  Two perivesical lymph nodes, positive for metastatic urothelial adenocarcinoma (2/2). 4. Prostate, radical cystoprostatectomy (c) - Adenocarcinoma of the prostate, Gleason score 3+4-7, involving less than 5% of the total prostatic tissue. The tumor is confined within the prostate.. - Bilateral seminal vesicles and prostatic resection margins are negative for tumor. 5. Left pelvic lymph nodes, excision (D) - Seven lymph nodes, negative for malignancy (0/7). 6. Left common iliac lymph nodes, excision (E) - Four lymph nodes, negative for malignancy (0/4). 7. Left paraaortic lymph nodes, excision (F) - Three lymph nodes, positive for metastatic urothelial carcinoma (3/3). 8. Right pelvic lymph nodes, excision (G) - Eleven lymph nodes, negative for malignancy. (0/l1). 9. Presacral lymph nodes, excision (H) - Three lymph nodes, positive for metastatic urothelial carcinoma (3/6). 10. Right common iliac lymph nodes, excision (I) - Four lymph nodes, positive for metastatic urothelial carcinoma (4/4)..  COMMENT
+
+--- Page 2 ---
+Encounter Date: .3. Specimen Type: Radical cystoprostatectomy. Tumor Size, Greatest dimension: 4.2 cm Histologic Type: : Urothelial carcinoma Urothelial Carcinoma: (wHO/ High-grade Adenocarcinoma and Squamous Carcinoma: N/A Associated Epithelial Lesions: Flat urothelial carcinoma in situ Margins: Margins uninvolved by invasive carcinoma Venous/Lymphatic (Large/Small Vessel) Invasion (v/L): Present. Direct Extension of Invasive Tumor: Perivesical fat Pathologic Stage: Primary Tumor: (pT) pT3b: Macroscopically invades perivesical fat (extravesical mass) Regional Lymph Nodes: (pN) pN2: Metastasis in multiple lymph nodes (true pelvis) Specify: Number examined: 37; Number involved (any size): 12 Distant Metastasis (pM):  pMx: Cannot be assessed 4. Gleason score: Primary 3, Secondary 4, Total 7. % of 4 and/or 5: 1-10% % of 3: 91-100% Androgen deprivation effect: Negative Negative Apical involvement:. Apical margin involvement: Negative Extraprostatic extension (Epe): Negative Margin: Negative Bladder neck shave: Negative Areas of involvement: left peripheral zone Principal area of involvement: left peripheral zone. Focality: unifocal Volume Low Greatest dimension of larger tumor nodule: 2 mm. Ejaculatory duct apparatus: Negative Seminal vesicles involvement (svi): Negative. Peri-sv involvement: Negative Vas deferens: N/A Peri-vas involvement: N/A High-grade PIN: Present Neuroendocrin?.. differentiation: Negative Diameter of largest lymph node metastasis (mm) N/A.   Lymphovascular invasion: Negative Page 2 of 5
+
+--- Page 3 ---
+Encounter Date:  . Other diagnoses: Atrophy and inflammation. Pathologic Stage: pT2a, pN0, pMx (Electronic Signature) SPECIMEN SUBMITTEDS A: RIGHT DISTAL URETERS B: LEFT DISTAL URETER C: BLADDER AND PROSTATES D: LEFT PELVIC LYMPH NODES E: LEFT COMMON ILIAC LYMPH NODES F: LEFT PARA AORTIC LYMPH NODES G: RIGHT PELVIC LYMPH NODES H: PRE-SACRAL LYMPH NODES I: RIGHT COMMON ILIAC LYMPH NODES CLINICAL DATA BLADDER CANCER INTRAOPERATIVE CONSULT DIAGNOSIS A. Negative for neoplasm (Dr. .. B. Negative for neoplasm (Dr.. GROSS DESCRIPTION A. Received fresh at the frozen desk labeled "right distal ureter" is a specimen consisting of red-tan soft tissue with a central lumen measuring 1.5 x 0.8x 0.5 cm. The specimen is totally submitted for frozen as FsAl. B. Received fresh at the frozen desk labeled "left distal ureter" is a specimen consisting of one fragment of red-tan soft tissue with a central lumen measuring 1.2 x 0.8 x 0.5 cm. The specimen is totally submitted for frozen as Fsbl. C. Received in formalin labeled "bladder and prostate" is a specimen consisting of a bladder and prostate measuring 17 x 10 x 5 cm. The specimen has been previously opened anteriorly. The bladder is inked black and the prostate is inked yellow on the left and blue on the right. The prostate measures 6 cm transversely, 4.5 cm anterior posteriorly, and 5 cm. craniocaudally. The seminal vesicles are unremarkable. The prostate shows no masses or lesions. The bladder reveals a large fungating mass in the left anterior wall measuring 2.3 x 1.2 x 0.8 cm. Inferior to this mass stretching from the anterior to the left wall is an ulcerated area measuring 1.5 x 0.7 cm. The area of ulceration abuts the left ureter orifice. Additionally seen is a focal area of hemorrhage in the posterior wall measuring 0.4 x 0.2 cm. Sectioning reveals the area under the ulcer and fungating mass to contain an infiltrative firm white lesion which extends to 0.5 cm from the inked black soft tissue margin. The remainder of the bladder mucosa is unremarkable. The prostate shows no masses or lesions. Representative sections are submitted as follows: C1 distal right ureter, C2 distal left ureter, C3 urethral margin, C4 left apex, C5 right apex, C6 3 mm left anterior, C7 3 mm right anterior, C8 3 mm left posterior, C9 3 mm right posterior, C10 6 mm left anterior, C11 6 mm right Page 3 of 5
+
+--- Page 4 ---
+Encounter Date: .anterior, C12 6 mm left posterior, C13 6 mm right posterior, C14 mid left anterior, C15 mid left middle (inked anterior), C16 mid left posterior, C17 mid right anterior, C18 mid right middle (inked anterior), C19 mid right posterior, c20 base left anterior, c21 base left lateral posterior, C22 base left mid medial posterior, c23 base right anterior, c24 base right posterior, C25 left seminal vesicle, C26 right seminal vesicle, c27 ulcer (submitted inferiorly to superiorly), c28-c29 deepest extent of white mass under ulcer, c30 ulcer with fungating mass, C31-c32 ulcer with mass, C33 remainder of mass, c34 remainder of mass (totally submitted), c35 superior bladder wall, C36 urethra, c37 posterior bladder wall with hemorrhage, C38 right bladder wall, C39 right ureter representative section, C40 left ureter with area of ulceration, C41-c42 possible lymph nodes.. D. The specimen is received fresh at the surgical desk labeled "left pelvic lymph nodes" and consists of a 6.5 x 6.0 x 1.0 cm segment of fibroadipose tissue. Sectioning reveals seven nodules consistent with lymph nodes. These nodules are submitted in cassettes Dl-D3. E. The specimen is received fresh at the surgical desk labeled *left common iliac lymph nodes" and consists of 3.2 x 2.0 x 1.0 cm segment of fibroadipose tissue. Sectioning reveals four nodules consistent with lymph nodes. These nodules are submitted in cassettes E1-E4.. F. The specimen is received fresh at the surgical desk labeled "left para-aortic lymph nodes" and consists of two nodules surrounded by fibroadipose tissue aggregating to 6.0 x 2.7 x 2.2 cm. Sectioning reveals a solid mass with red-tan parenchyma with areas of granular appearing parenchyma which is more of a yellow tan color. Sections are submitted as follows: F1 smaller nodule, bisected, F2-F3 representative sections of the larger nodule. G. The specimen is received fresh at the surgical desk labeled "right pelvic lymph nodes" and consists of an 8.0 x 5.0 x 2.0 cm segment of fibroadipose tissue with multiple nodules contained within. These nodules are submitted as follows: G1-g2 multiple nodules, G3 single nodule sectioned, G4 five nodules, G5 three nodules.. H. The spscimen is received fresh at the surgical desk labeled "presacral lymph nodes" and consists of a 4.0 x 2.0 x 1.0 cm segment of fibroadipose tissue with nodules consistent with lymph nodes contained within. The specimen is submitted as follows: H1-H2 fibroadipose tissue with multiple nodules, H3 single nodule, sectioned. I. The specimen is received fresh at the surgical desk labeled "right common iliac lymph node" and consists of a 6.0x 4.0 x 1.0 cm segment of fibroadipose tissue with multiple nodules consistent with lymph nodes contained within. Sections are submitted as follows: Il-I6 nodules, one per cassette. Patient ID #: DOB: (Age: Date of Report:. Date of Procedure: Date of Receipt:.  Page 4 of 5
+
+--- Page 5 ---
+Encounter Date1 Submitted by: : Location: Test performed by: Lab and Collection SURGICAL PATHOLOGY (Order  - on Lab and Collection Information. Result History SURGICAL PATHOLOGY (Order) on - Order Result History Report.. Result Information Result Date and Time Status Provider Status Final result Reviewed MyChart Status... This result is currently not released to Display Full Result Report Display Order Report Page 5 of 5
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+UUID: 513B512E- E9DF-4628-BD36-CADBF3725D9A TCGA-WC-A888-01A-PR Redacted Accession: Specimen Date/Time: DIAGNOSIS (61-90%) (A) RIGHT GLOBE: 1-3o ) CHOROIDAL MELANOMA, MIXED SPINDLED AND EPITHELIOID CELL TYPES 15 mm base x 11mm height LCD O -3 Scleral invasion: absent Vortex veins: negative for tumor. Optic nerve: negative for tumor. CeQC mmizeel. 8770/3 See comment. Sub. RChwroesl C69.3 COMMENT 91/1i|14 Mitoses are than 1 per 10 hpf. PATHOLOGIC STAGE BASED ON PATHOLOGY MATERIAL REVIEWED IN THIS ACCESSION Primary tumor: pT3 Regional lymph nodes: pNX Distant metastases: pMX (American Joint Committee on Cancer, 7th Edition, 2010) GROSS DESCRIPTION (A) RIGHT GLOBE - An enucleation specimen (22 mm anterior to posterior, 23 mm medial to lateral, and 23 mm superior t inferior), has an attached 2 cm optic nerve. The skull surface is unremarkable. The cornea is clear and formed by a 10x11. brown iris which has an eccentric 4 mm pupil. A shadow is present in the temporat aspect approximately 15 x 15 mm base 7 mm from the optic nerve and 5 mm from the limbus, this corresponds to a brown tumor centered on the choroid with an 1. height. The eye is opened fresh for protocol harvest. The vitreous is watery. The choroid appears intact beneath the tumor. SECTION CODE: A1, vortex veins; A2, optic nerve with margin en face; A3-A5, trisection of globe (A5 wih pupil op nerve section). BIOMARKER TESTING Primary Tumor Block: A4 CLINICAL HISTORY None given. SNOMED CODES T-AA000, M-87203 *Some tests reported here may have been developed and performance characteristics determined by These tests have no specifically cleared or approved by the U.s. Food and Drug Administration." Entire report and diagnosis completed by:. -END OF REPOrT- a: als
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diff --git a/output/text/54f56359-46de-44ac-b9b2-537434d898c9.txt b/output/text/54f56359-46de-44ac-b9b2-537434d898c9.txt
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+PATIeNt hISTory: CHIEF COMPLAINT/ PRE-OP/ POST-OP DIAGNOSIS: Loft bresst invasrve ductal carcinoma.e LMP DATE NoI applicable PROCEOURE Lot segmental mastectomy with sentine! lymph node blopsy. Jcs-0-3 SPECIFIC CLINICAL QUESTION: Not Itsted. OUTSIDE TISSUE DIAGNOSIS: Not listed Carmimr,nif1truting chuch! nos 850c/3 PRIOR MALIGNANCY. Not listed. CHEMORADIATION THERAPY: Not Ilsted SiFu.5ust,nrs c5u 9 h 3f28/1 OTHER DISEASFS Nol listed FINAL DIAGNOSIS: Part 1: Lymph node. non-sentnel. Biopsy -- . . One (1) Lymph node, negative.fOr metastatic.carcinoma (0v1).. . PArt 2: Lymph node, LEft axILLA, Sentinel #1, BIOpSy -- ONe (1) LyMPh nODE. NEgATIVE fOR METASTATIC CARcINOmA (0/1). Part 3: Lymph nOde, LEft AXILLA, SEntinel #2, BiOpsy - One (1) Lymph nOde. negative fOr metastATiC Carcinoma (0/1) Part 4: Breast, Left, Segmental mastectomy --  InyaSiye Ductal carcinoma, no special type. 4 NOttinghAm GrADe in (TUBuLe fOrmATiOn: 3, nUcleaR PleOmOrphIsm: 3, miTOtic AcTtmiTy: 3; TOTAL SCORE: 9/9). The invAsive Tumor neasures 2.6 Cm in LArgest DimensiON. D. Ductal. carcinoma in situ, nuclear grade 3, solib type with comedo necrosis. E The DuctAL CArcinomA in SiTu COnstITutEs 40% OF The TOtAL TUmOr vOLUme And is PREsEnte Admixe? with the invasive component. F No' lymphovascular space invasion is noted. G.  Resection margins are negative for carcinoma.  invasive carcinoma is o.4 cm From the nearest (Anterior) margin. Ductal CarcinOma in srtU is 0.3 Cm FRom the neArest (AnterIoR) mArgin.e Atypical Ductal hyperplasia. K THE non-neoplasTic Breast shows DuctAL epiTheLial hyperplasiA, intraductAl Papilloma, Radial scar, columnar cell. Changes, and fibrocystic Changes. PREVIOUS BIOPSY SITE CHANGES. Part 5: Lymph noDe, Left "Intramammary", Excisional siOpsy -- One (1) LyMPh nOde, nEgatIive fOr MetastATic.cArcinoma (01). B.  BENIGN PERINODAL ADIPOSE TISSUE.  No ouctal breast tissue seen. COmment: Part 4: The invasive tumor was reported to be positive for Eatrogen Roceptora (H-ecore; 250), positive for Progesterone Receptors (H-score: 75) and aiso positve for HER2, ss per previous pathology report (** CASE SYNOPSIS:  SyNOptic - PRImARy INVAsive CArciNomA Of BreAST LATERALITY: Lef! PROCEDURE: Segmental LOCATION: Clock positlon.12 SiZE OF TUmOR: Maximum dimension invasive component: 26 mm MULTICENTRICiTY/MuLTIFOCALITY OF INVASivE FOCi:E No TUMOR TYPE (invasive component): Ductel adenocarangma, NOS NOTTINGHAm SCORE:E Nudeer grade: 3 Tubule formation: 3 UUID:57323AES-3EFE-4492-8522-D9A6D83F1BE0  Redacted Mitotic activity score: 3 TCGA-BH-A202-01A-PR Total Nottingham score: 9. Nottingham grade (1. 2. 3): 3 ANGIOLYMPHATiC INVASION: No DeRmAl LymphATic inVaSION: Not applicable CALCIFICATION: No Tumor type, in situ: Solid Comedo  SURgICAl. MARGINS InVOLVED ay inVASIvE COMPOnEnt: No Distance of invasive tumor to closest margin: 4 mm Surg nargins involved by in situ component: No Distance of in situ disesse to closest margin: 3 mm LYMPH NODES POSITIVE; 0 LyMPH NODES EXAMINED: 4 mEThOD(S) Of LymPh nODE ExAmnAtION: H/E stain SENTINEL NODE METASTASIS: NON-NEOPLASTiC BREAST TISSUE: Radial scar, PapiHoma, FCD No T stage, pathologic: pT2 N STAGE mODIFIER: (sn) N stage, pathologic: pNO m stage: Not appicable ESTROGEN RECEPTORS: postive, H-score 250 PROGESTERONE RECEPTORS: positive, H-score: 75 HER2INEU: 3+ HIPA
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+Ducfnl +Mucws T AW|rofarf  UUID: 92EE56BF -AAA0-438E - 9244-780DBB2D9835 TCGA-A1-A0SQ-01A-PR Redacted Ied-0-3 Pat Site : budot, nos C50. 1e/3./1 CQCFCscW~mr nfltnnMy duct,N0s 8500/3 Final Pathologic Diagnosis:. A. Lymph node, left axilla, sentinel #1, biopsy: No carcinoma in one lymph node (0/1). B. Lymph node, Ieft axilla, sentinel #2 , biopsy: Metastatic carcinoma in one lymph node (1/1). Page I of'8
+
+--- Page 2 ---
+Surgical Pathology - Working Draft C. Lymph node, left axilla, sentinel #3, biopsy: No carcinoma in one ly..u node (0/1). D. Right breast, skin-sparing mastectomy:. 1. Non-proliferative fibrocystic change 2. Focal lactational change. 3. No carcinoma. E. Right breast, nipple tissue, excision: No significant pathologic abnormality; no carcinoma.. F. Left breast, skin-sparing mastectomy:. 1. Invasive ductal carcinoma, 3.8 cm, SBR grade 2; see comment. 2. "Ductal carcinoma in situ, intermediate grade, associated with invasive carcinoma. 3. Microcalcifications associated with invasive carcinoma. G. Left breast, nipple tissue, excision: No significant pathologic abnormality;. no carcinoma. H. Right axilla, accessory nipple, excision: Findings consistent with accessory nipple tissue; no carcinoma. I. Lymph nodes, left axilla, levels 1 and 2, dissection: No carcinoma in twelve lymph nodes (0/12). J. Left axilla, accessory nipple, excision: Findings consistent with accessory. nipple tissue; no carcinoma.. Note: Breast Tumor Synoptic Comment. - Lateratity: Left. - Invaslve tumor type: Invasive ductal carcinoma with mucinous features. - Invasive tumor size: 3.8 cm (slices 1 to 5 contiguous at 0.75 cm thickness per slice).. - Invasive tumor grade (modifled Bloom-Richardson): Grade 2.. Nuclear grade: 3, =3 points. Mitotic count: <10 mitotic figures/10 HPF, =1 point. Tubule/papilia formation: 10 to 75%, = 2 points. Total points and overall grade = 6 points = grade 2. - Lymphatic-vascular invasion: Present.. - Skin/nipple: On main specimen there is no nipple tissue. In separately submitted left nipple specimen (Part G) there is no Involvement by carcinoma. - Margins for invasive tumor: Negative.. - Deep margin: Close; (tumor is 0.05 cm (0.5 mm) away, on slide F3) - Medial margin: Negative; (tumor is >5 cm away). - Lateral margin: Negative; (tumor is 1.4 cm away, on slide F1).. - Anterior/superior margin: Negative; (tumor is 0.4 cm away, on slide F16). - Anterior/inferior margin: Negative; (tumor is 0.2 cm away, on slide F1). - Ductal carcinoma in situ (Dcis): Solid with mucinous features.. - Ductal carcinoma in situ size: - DCIS present in contiguous sections, spanning 5.3 cm. - Ductal carcinoma in situ nuclear grade: Intermediate.. Page 2 of 8
+
+--- Page 3 ---
+Surgical Pathology - Working Draft - Necrosis in Dcis: None. - Microcalcifications: Present, involving invasive carcinoma. - Resection margins for ductal carcinoma in situ: Negative - Deep margin: Close; (tumor is 0.5 mm away, on slide F3). - Medial margin: Negative; (tumor is >5 cm away). - Lateral margin: Negative; (tumor is > 1 cm away). - Anterior/superior margin: Negative; (tumor is 0.2 cm away, on slide F16). - Anterior/inferior margin: Negative; (tumor is 0.2 cm away, on slide F1).. - Lymph node status: Positive. - Number of positive lymph nodes: 1. - Total number sampled: 15. - Diameter of largest metastasis: 0.5 cm (slides B1, Fs2 (8)) - Extranodal extension: None - AJCC/UICC stage: pT2N1mX. Hormone receptor status was previously evaluated on this tumor. However, receptor status was requested again on the specimen and the resuits will be reported in an addendum. Intraoperative Consult Diagnosls FS1 (A) Left axilla, sentinel lymph node #1, biopsy: No tumor in one lymph node (0/1). (Dr. FS2 (B) Left axilla, sentinel lymph node #2, biopsy: Metastatic carcinoma in one lymph node, 5 mm focus, with no extranodal extension noted (1/1). (Dr. .) FS3 (C) Left axilla, sentinel lymph node #3, biopsy: No tumor in one lymph node (0/1). (Dr. Ciinical History The patient is a year-old woman with infiltrating ductal carcinoma of the left breast, diagnosed by. needle core biopsy She now undergoes bilateral skin-sparing mastectomy, left axillary. sentinel lymph node uiopsy, left axillary lymph node dissection, and excision of bilateral axillary accessory nipples. Gross Description The specimen is received in ten parts, each labeled with the patient's name and medical record number. Part A is received fresh and is additionally labeled It conslsts of a single pink-tan, ovoid lymph node candidate wlth attached fibrofatty tissue, measusing 1 x 0.8 x 0.5 cm in greatest dimensions. The fibrofatty tissue is trimmed, and the lymph node candidate is bisected and entirely submitted for frozen section diagnosis #1. The frozen section remnant is subsequently submitted in cassette A1. The remaining fibrofatty tissue is submitted in cassette A2. Part B is received fresh and is additionally iabeled It consists of a single roughly ovoid, pink-tan lymph node candlaate wiu auacnea sort nororatty tissue, measuring 1.6 x 1 x 0.6 cm in greatest dimensions. The fibrofatty tissue is trimmed, and the lymph node candidate is bisected and entirely submitted for frozen section diagnosis #2. The frozen section remnant is subsequently submitted in cassette B1. The remaining fibrofatty tissues are submitted in cassette B2. Part C is received fresh and is additionally labeled It consists of a single small, soft, roughly ovoid, pink-tan lymph node candidate with attached fibrofatty tissue, measuring 1.3 x 0.7 x 0.5 cm in aggregate. The fibrofatty tissue is trimmed, and the lymph node candidate is bisected and entirely submitted for frozen section diagnosis #3. The frozen section remnant is subsequently submitted in cassette C1. The remaining fibrofatty tissue is submitted in cassette C2. Pare 3 of 8
+
+--- Page 4 ---
+Surgical Pathology - Working Draft Part D ie rnceived fresh. labeled - SPecIMeN TYPe: Skin-sparing mastectomy. - Skin elLIpse: Not present. - NIppLe: Not present. - Orientation: - Long suture: Lateral. - Short suture: Superior. - Double suture: Nipple remnant. - INKInG (for microscopic evaluation): - Black: Posterior margin. - Green: Anterior inferior margin. - Blue: Anterior superior margin. - Yellow: Nipple remnant. - Size Of specimen: - Medial-Lateral dimension: 13.5 cm. - Superior-Inferior dimension: 13.8 cm. - Anterior-Posterior dimension: 1.7 cm. - total number Of Slices: 19. - First slce (slice 1): Lateral margin. - Last slice (slice 19): Medial margin. - GRoss PAthoLOgy: On cut section, the specimen consists of unremarkable pink-white breast parenchyma and tan-yellow fibroadipose tissue. No gross lesions are identifled. Representative sections are submitted as follows: Cassette D1: Slice 4, upper outer quadrant, two sections. Cassette D2: Slice 7, upper outer quadrant. Cassette D3: Slice 5, lower outer quadrant, two sections. Cassette D4: Slice 7, lower outer quadrant. Cassette D5: Slice 13, upper inner quadrant. Cassette D6: Slice 15, upper inner quadrant. Cassette D7: Slice 14, lower inner quadrant. Cassette D8: Slice 16, lower inner quadrant. Cassette D9: Slice 12, nipple remnant. Part E is received fresh and is additionally labeled " : It consists of a single irregular, unoriented fragment of pink-white soft tissue, measuring 0.3 x 0.3 x 0.2 cm. The specimen is inked blue, bisected and entirely submitted in cassette E1. Part F is received fresh, labeled ". - SPECImeN TyPE: Skin-spariny lidstecluny. - Skin ellIpse: Not present. - Nipple: Not present. - Orientation: - Long suture: Lateral. - Short suture: Superior. - Double suture: Nipple remnant. - INkInG (for microscopic evaluation): - Black: Posterior. - Green: Anterior inferior. - Blue: Anterior superior. - Yellow: Nipple remnant. - SIze Of SpecImeN: - Medial-Lateral dimension: 12 cm. - Superior-Inferior dimension: 12.5 cm. - Anterior-Posterior dimension: 1.6 cm. - total number of slices: Sixteen. - First slice (slice #1): Lateral margin. Page 4 of 8
+
+--- Page 5 ---
+Surgical Pathology --  Working Draft - Last slice (slice #16): Medial margin. - Gross pAthoLOgy: An irreguiar, firm, poorly circumscribed, pink-white soft tissue mass is. present in siices 2-6. The soft tissue mass measures 5 cm from medial to lateral, 4.5 cm from superior to inferior, and 1.1 cm from anterior to posterior. It is 1.5 cm from the lateral specimen margin (slice 2), 3 cm from the inferior specimen margin (slice 2), 4.5 cm from the superior margin (slice 4), abuts the deep margin (slices 2-5), and >5 cm from the medial margin. The remainder of the breast parenchyma consists of yellow fibroadipose tissue and unremarkable pink-white soft tissue and no additional mass lesions are identified. Gross photographs are taken for future correlation. A portion of the tumor is taken for tissue banking. Representative sections are submitted as follows: Cassettes F1-F2: Slice 1, latera! margin, adjacent to soft tissue mass in sllce 2, perpendicularly. sectioned. Cassette F3: Slice 2, mid-inferior portion. Cassette F4: Slice 2, inferior portion. Cassettes F5-F8: Slice 3, mid-superior to inferior portion, submitted sequentially from superior to inferior. Cassettes F9-F13: Slice 4, mid-superior to inferior portion, submitted sequentially from superior to. inferior. Cassettes F14-F19: Slice 5, entirely submitted submitted sequentially from superior to inferior.. Cassette F20: Slice 6, mid-superior portion. Cassette F21: Slice 6, mid portion. Cassette F22: Slice 6, mid inferior portion. Cassette F23: Slice 14, mid superior. Cassette F24: Slice 14, mid inferior. Cassette F25: Slice 12, mid superior and mid inferior.. Cassette F26: Slice 13, mid superior. Cassette F27: Slice 11, mid superior. Cassette F28: Slice 16, medial margin, perpendicularly sectioned.. Cassette F29: Slice 7, mid superior. Cassette F30: Slice 8, mid superior. Cassette F31: Slice 9, mid superior. Cassette F32: Slice 10, mid superior. Part G is received fresh and is additionally labeled It consists of a single irregular, unoriented fragment of white-tan soft tissue, measuring 0.7 x 0.5 x 0.4 cm. The specimen is inked blue, bisected, and entirely submitted in cassette G1. Part H is received fresh and is additionally labeled It consists of a single ellipse of unremarkable, tan-white skin, measuring 1.3 x 0.9 cm. A short suture marks the superior margin, and a long suture marks the posterior-laterat margin. The superior margin is inked blue, the inferior margin is inked green, and the deep margin is inked black for microscoplc evaluation. The specimen is serially sectioned, from Iateral to medial, into four slices and is entirely submitted in cassette H1. Part I is received fresh and is additionally labeled consists of multiple irregular, unoriented fragments of yellow-tan soft tissue, measuring 4.6 x 4.3 x It 1.5 cm in aggregate. The specimen is carefully dissected to reveal fourteen candidate lymph nodes, ranging from 1.1 to 0.3 cm in maximum dimensions. The candidate lymph nodes are submitted in cassettes as follows: Cassette I1: Three candidate lymph nodes, inked and bisected. Cassette 12: Six candidate lymph nodes, submitted intact. Cassette I3: Five candidate lymph nodes, submitted Intact.. Part J is received fresh and is additionally labeled It consists of an ellipse of unremarkable, tan-white skin, measuring 0.9 x 0.4 cm. A short suture marks the superior margin, and a long suture marks the lateral margin. The superior margin is inked blue, the inferior margin is inked green, and the deep margin is inked black for microscopic evaluation. The specimen is bisected, from superior to inferior, and entirely submitted in cassette J1. Page 5 of 8
+
+--- Page 6 ---
+Surgical Pathology . Working Draft /Pathology Resident 'Pathologist Signed: Fee Codes: Addenda Addendum. Date Ordered: Status: Signed Out Date Complete: By: Date Reported: Addendum Comment An immunohistochemical test for estrogen and progesterone receptors was performed by manual. morphometry on block F3. The test for estrogen receptors is positive. There is 3+ nuclear staining in >9o% of tumor cells. Internal positive control is positive. The test for progesterone receptors is positive. There is 2-3+ nuclear staining in >90% of tumor celis. Internal positive control is positive. Resuit of HER2/neu test: This carcinoma is negative for HER2/neu oncoprotein over-expression. An immunohistochemical assay was performed by manual morphometry on block # using the CB11. monoclonal antibody to HER2/neu oncoprotein. The staining intensity of this carcinoma was 1 on a. scale of 0-3. Carcinomas with staining intensity scores of 0 or 1 are considered negative for over-expression of HER2/neu oncoprotein. Those with a staining intensity score of 2 are considered indeterminate. We and others have observed that many carcinomas with staining intensity scores of 2 do not show gene amplification. All carcinomas with staining intensity scores of 2 are therefore submitted for FIsh testing. The results of the Fish test are issued directly from the molecular cytogenetics laboratory. Carcinomas with staining intensity scores of 3 are considered positive for over-expression of HER2/neu oncoprotein. Tumors in this category show an excellent correlation between the results of immunohistochemical and FISH testing, and almost always show gene amplification. HER2/neu. Interpreted by Dr. Pathologist Electronically signed out on Paze 6 of 8
+
+--- Page 7 ---
+Surgical Pathology - I Working Draft Other Specimens _Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Cervical/Endocervical, Thin Prep Imaged Final Diagnosis Cervical/Endocervical, Thin Prep Imaged NEGATIVE FOR INTRAEPITHELIAL LESION OR MALIGNANCY. Reactive cellular changes. Inflammation. See Below. SPECIMEN ADEQUACY: Satisfactory for evaluation. Transformation zone components are present. Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: A: Left chest lesion, B: Left Breast, implant capsule, C: Right Breast, implant capsule Final Diagnosis A. Skin, left chest, excision: 1. Skin with papillary epidermal hyperplasia and focal dermal smooth muscle proliferation; see comment. 2. No carcinoma. B. Left breast, capsulectomy: 1. Implant capsule. 2. Benign breast tissue. 3. No carcinoma. C. Right breast, capsulectomy: 1. Implant capsule. 2. No carcinoma. -Specimen Class: Status: Signed Out Accessloned Signed Out: Specimen(s) Received: Left breast, needle core biopsy Final Diagnosis Left breast, needle core biopsy: 1. Infiltrating ductal carcinoma with prominent mucinous component, modified BR grade 2, 0.25 cm; see comment. 2. Ductal carcinoma in situ without necrosis, not otherwise specified, intermediate grade; see comment. Paee 7 of R
+
+--- Page 8 ---
+Surgical Pathology : Working Draft Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Left Breast, Fine Needle Aspiration. Final Diagnosis Leit Breast, Fine Needle Aspiration: Fibrocystic change, see note. END OF REPORT  Page 8 of 8
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+FINAL DIAGNOSIS: Part 1: _breast, right, needle Localized segmental mastectomy - A.  iNVASIVE DUCTAL CARCiNOMA, 2.0 Cm (GROSS), NOTTiNGHAm GRADE 1 (COMBINED NOTTINGHAm SCORE 4/9: TUBULe fORmATiON 1/3, nUCLEAR PLEOmOrphISm 2/3, mItOtiC ActiviTy 1/3). 8. DUCTAL CARCINOmA IN SITU (DCIS), nUCLEAR GRADE 2, CRIBRIfORm TYPE, CONSTITUTES AppROXimATeLy 5% Of THe TUmOR VOLUme aND iS ADMiXeD WIth THe InVASIVE COMpONeNT. C. LYMPHOVASCULAR SPACE INVASION IS nOT IDENTIFIED. D. MARGINS FREE, CLOSEST ANTERIOR/SUPERIOR WITHIN 0.6 CM. DUcTaL EpITHeLIAl hYPERplASIA. FIBROCYSTIC CHAnGES. G. SCLEROSING ADENOSIS. H. COlumnaR CELl Change. 1. FIBrOADeNOMATOId nODULes. J. SKIn is negatiVe fOR tumor. K. BIOPSY SITE CHANGES. Part 2: Lymph noues, kighi, Seniinel t!, -.  METASTATiC CARCINOMA (0.4 CM.) iNVOLVES ONE OF TWO LYMPH NODES (1/2) (see comment). A. B. EXTRACAPSULAR EXTENSiON IS IDENTiFIeD, 0.1 CM X 0.07 CM. Part 3: Lymph noDe, Right, Sentinel #2, Biopsy -- A. metastatic carcinOma involves One Lymph nOde (1/1) (see comment). B.  ExTracapsuLaR exTensIOn Is nOT identifIed. Part 4: Lymph nodt, kigni, deniinel ?3, biopsy - ONE LYMPH NODE, NEGATIVE FOR METASTATIC CARCINOMA (0/1) (see Comment). part 5: breast, Right, new Lateral margin, excision - A.  RADIAL SCAR. B. FIBROCYSTIC CHANGES. C. SCLEROSing ADEnOsIS. D. DUCTAL EPITHELIAL HYPERPLASIA. E.  COLUMNAR CELL CHANGE WITH ASSOCIATED CALCIFICATIONS. F. FAT NECROSIS. oc sinUpSIS: SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST LATERALITY: Right PROCEDURE: Segmental LOCATION: Not specified SIZE OF TUMOR: Maximum dimension invasive component: 2 cm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: Yes TUMOR AGGREGATE SIZE: Sum of the sizes of multiple invasive tumors: 2.5 cm. TUMOR TYPE (invasive component): Ductal adenocarcinoma, NOS NOTTINGHAM SCORE: Nuclear grade: 2 1Cb-0-3 Tubule formation: 1 earcnvma7 mifif+nstng ouctd, no3 85osf3 Mitotic activity score: 1 Tota! Nottingham score: 4 SiHe brsst,Ns C50,9 3/3/n hw Nottingham grade (1, 2, 3): 1 ANGIOLYMPHATIC INVASION: No DERMAL LYMPHATIC INVASION: No CALCIFICATION: Yes, benign zones Yes, malignant zones Tumor type, in situ: Cribriform DCIS admixed with invasive carcinoma Percent of tumor occupied by in situ component: 5 % SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No SURG MARGINS INVOLVED BY IN SITU COMPONENT:E UUID:DFB21194-30C7-430E-A53C-C38345209B1F3 No TCGA-BH-A0EI-01A-PR Redacted LyMPH NODES POSITIVE: 2 LYMPH NODES EXAMINED: 4 mEtHOD(S) OF LymPh NODE EXAmiNATION: H/E stain, Keratin stain SENTINEL NODE METASTASIS: Yes SIZE OF NODAL METASTASES: Diameter of largest lymph node metastasis: 4 mm LYMPH NODE METASTASIS(-ES) WITH EXTRACAPSULAR EXTENSION: Yes t Stage, pathologic: pT1c N Stage, pathologic: pN1 m Stage, pathoLogic: pMX y Tmor Sitc Estrogen receptors: positive PROGESTERONE RECEPTORS: positive HER2/NEU: zero or 1+ 3/3/1r
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diff --git a/output/text/551f3383-dec5-41fa-9a25-19a19ba6be23.txt b/output/text/551f3383-dec5-41fa-9a25-19a19ba6be23.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ac9b3ec7ef6848ec628473c36f236a453fa130a7
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+UUID:77028628-13A0-486E-866E-C10DDF141B2B TCGA-XF-A9Sm-01A-PR Page 1 of 5 Redacted FINAL DIAGNOSIS: OE ICDO- RIGHT DISTAL URETER (A) FROZEN SECTION DIAGNOSIS: NO CARCINOMA IN SITU 81q0|3 FINAL DIAGNOSIS: BENIGN URETER NO CARCINOMA IN SITU OR MALIGNANCY IDENTIFIED Cariiona,trarutonascellN$ 8120l3 LEFT DISTAL URETER (B) : FROZEN SECTION DIAGNOSIS: Sit yladolr Nos NO CARCINOMA IN SITU Cb7 9 FINAL DIAGNOSIS: BENIGN URETER QJ 3|26|14 NO CARCINOMA IN SITU OR MALIGNANCY IDENTIFIEDS URETHRAL MARGIN (C: FROZEN SECTION DIAGNOSIS: NO CARCINOMA IN SITU CHRONIC INFLAMMATION WITH GRANULOMAS, CONSISTENT WITH BCG FINAL DIAGNOSIS: NO CARCINOMA IN SITU CHRONIC INFLAMMATION WITH GRANULOMAS, CONSISTENT WITH BCG THERAPYS o% 91uvdulsv pw 7SS BLADDER (C):  POORLY DIFFERENTIATED TRANSITIONAL CELL CARCINOMA WITH GLANDULAR i0?  Squanus DIFFERENTIATION, NUCLEAR GRADE 4 OUT OF 4, MEASURING 7 X 5 X 3 CMS pU 755 TUMOR INVADES THROUGH FULL THICKNESS OF MUSCULARIS PROPRIA INTO SURROUNDING FIBROFATTY TISSUE ALL INKED MARGINS AND PERITONEAL SURFACE ARE FREE OF TUMOR NO LYMPHOVASCULAR SPACE INVASION IDENTIFIED CARCINOMA IN SITU (SLIDE C13) UNINVOLVED BLADDER SHOWS MARKED CHRONIC CYSTITIS AND CYSTITIS GLANDULARIS, AND GRANULOMATOUS REACTIONS PROSTATE (C) :) BILATERAL PROSTATIC ADENOCARCINOMA, GLEASON' S SCORE 6 (3+3) TUMOR FOCALLY INVADES INTO BUT NOT THROUGH CAPSULE INKED RADIAL MARGINS ARE FREE OF TUMOR NO LYMPHOVASCULAR SPACE INVASION IDENTIFIED BILATERAL SEMINAL VESICLES AND VASA DEFERENTIA, FREE OF TUMOR GRANULOMATOUS PROSTATITIS CONSISTENT WITH BACILLE CALMETTE-GUERINS (BCG) THERAPY PARA-AORTIC LYMPH NODES (D) :  NO METASTATIC CARCINOMA IDENTIFIED IN 19 LYMPH NODES EXAMINED (0/19) PARACAVAL LYMPH NODES (E):)  NO METASTATIC CARCINOMA IDENTIFIED IN EIGHT LYMPH NODES EXAMINED (O/8)) RIGHT COMMON ILIAC LYMPH NODES (F) :  NO METASTATIC CARCINOMA IDENTIFIED IN THREE LYMPH NODES EXAMINED (0/3) LEFT COMMON ILIAC LYMPH NODES (G) :  NO METASTATIC CARCINOMA IDENTIFIED IN NINE LYMPH NODES EXAMINED (O/9)) RIGHT EXTERNAL ILIAC LYMPH NODES (H) :)  NO METASTATIC CARCINOMA IDENTIFIED IN 13 LYMPH NODES EXAMINED (0/13) RIGHT LYMPH NODE OF CLOQUET (I):
+
+--- Page 2 ---
+Page 2 of 5 NO METASTATIC CARCINOMA IDENTIFIED IN TWO LYMPH NODES EXAMINED (O/2) RIGHT HYPOGASTRIC/OBTURATOR LYMPH NODES (J) :) NO METASTATIC CARCINOMA IDENTIFIED IN 15 LYMPH NODES EXAMINED (0/15) LEFT EXTERNAL ILIAC LYMPH NODES (K) : NO METASTATIC CARCINOMA IDENTIFIED IN SEVEN LYMPH NODES EXAMINED (O/7) LEFT LYMPH NODE OF CLOQUET (L): NO METASTATIC CARCINOMA IDENTIFIED IN ONE LYMPH NODE EXAMINED (O/1) LEFT HYPOGASTRIC/OBTURATOR LYMPH NODES (M) :) NO METASTATIC CARCINOMA IDENTIFIED IN 13 LYMPH NODES EXAMINED (0/13) LEFT PRESCIATIC LYMPH NODES (N) :  NO METASTATIC CARCINOMA IDENTIFIED IN SEVEN LYMPH NODES EXAMINED (O/7) RIGHT PRESCIATIC LYMPH NODES (O) : NO METASTATIC CARCINOMA IDENTIFIED IN THREE LYMPH NODES EXAMINED (0/3)) PRESACRAL LYMPH NODES (P) :  NO METASTATIC CARCINOMA IDENTIFIED IN FOUR LYMPH NODES EXAMINED (O/4) LEFT PROXIMAL URETER (Q): BENIGN URETER NO CARCINOMA IN SITU OR MALIGNANCY IDENTIFIED RIGHT PROXIMAL URETER (R) : BENIGN URETER NO CARCINOMA IN SITU OR MALIGNANCY IDENTIFIED PROSTATE: pT2cNOMX BLADDER: pT3bN0MX INTRAOPERATIVE DIAGNOSIS: FROZEN SECTION DIAGNOSIS: AFs:  Right distal ureter:  no carcinoma in situ BFS: Left distal ureter:  no carcinoma in situ CFS: Urethral margin:  no carcinoma in situ chronic inflammation with granulomas consistent with BCG GROSS DESCRIPTION: A: The specimen is received fresh from the O.R. and labeled "Right distal ureter.. It consists of a segment of ureter measuring 0.4 cm in length and 0.6 cm in. circumference.  The specimen is entirely submitted for frozen section in cassette. AFs. B: The specimen is received fresh from the O.R. and labeled "Left distal ureter.# It consists of a segment of ureter measuring 0.2 cm in length and 0.8 cm in. circumference. The specimen is entirely submitted for frozen secton in cassette. Bes. C: The specimen is received fresh from the O.R. and labeled "Bladder & prostate.".
+
+--- Page 3 ---
+Page 3 of 5  of bladder and prostate measuring 23 x 18 x 6 cm overall. The peritoneum measures 24 x 15 x 1 cm.  The peritoneal surface is smooth with a focal area of adhesion measuring 2 x 2 cm.. The bladder measures 9 x 6 x 5 cm. The right distal ureter measures 7 cm in length and 1 cm in circumference.  The left distal ureter measures 6 cm in length and o.4 cm in circumference. The ureteral mucosa is. smooth with no gross lesion identified.  There is a large, gray-white, firm lesion. located in the anterior and the right side of bladder wali measuring 7 x 5 x 3 cm.. The tumor grossly invades the full thickness of the bladder wall and into surrounding soft tissue.  The soft tissue margin is negative of tumor grossly. The prostate measures 7 x 6 x 5 cm. The prostatic urethra measures 4.5 cm in length and 2 cm in circumference. The verumontanum measures 0.7 x 0.5 x 0.4 cm.  There is no gross lesion identified in the prostatic urethra.. The left prostate is inked. blue, and the right prostate is inked black.  The prostate is serially sectioned and reveals a focal yellow lesion located in the midprostate, measuring 0.3 cm in maximum dimension.. Representative sections are submitted in 33 cassettes. D  The specimen is received in formalin and labelled "Para aortic lymph nodes." It consists of multiple pieces of yellow fatty tissue measuring 6 x 5 x 2 cm in aggregate.  There are multiple lymph nodes identified. Representative sections are submitted in four cassettes.. E: The specimen is received in formalin and labelled "Para caval lymph nodes." It. consists of multiple pieces of yellow-tan fatty tissue measuring 5 x 3 x 1 cm in aggregate. There are multiple lymph nodes identified. Representative sections are submitted in two cassettes.. F:  The specimen is received in formalin and labelled "Right common iliac lymph nodes." It consists of multiple pieces of yellow fatty tissue measuring 3 x 3 x 1 cm in aggregate. There are multiple lymph nodes identified. Representative sections are submitted in one cassette. G: The specimen is received in formalin and labelled "Left common iliac lymph nodes." It consists of a piece of yellow fatty tissue measuring 2 x 2 x 1 cm. There are multiple lymph nodes identified. Representative sections are submitted in one cassette. H: The specimen is received in formalin and labelled sRight external iliac lymph nodes." It consists of a piece of yellow fatty tissue measuring 6 x 3 x 1 cm.. There are multiple lymph nodes identified. Representative sections are submitted in three cassettes. I: The specimen is received in formalin and labelled Right lymph node of cloquet." It consists of a piece of yellow fatty tissue measuring 2 x 1 x 0.6 cm. The specimen is bisected and entirely submitted in one cassette. J:  The specimen is received in formalin and labelled "Right hypogastric ! obturator lymph nodes." It consists of multiple pieces of yeliow fatty tissue measuring 6 x 5 x 2 cm in aggregate..  There are multiple lymph nodes identified The largest piece measures 2 cm in maximum dimension. Representative sections are. submitted in one cassette.  The specimen is received in formalin and labelled "Left external iliac nodes." It consists of a piece of yellow fatty tissue measuring 5 x 3 x 2 cm. There are multiple lymph nodes. The largest one measures 3 cm. Representative sections are submitted in three cassettes. L:  The specimen is received in formalin and labelled "Left lymph node of cloquet. It consists of a piece of yellow fatty tissue measuring 1.5 x 1 x 0.6 cm.. specimen is bisected and entirely submitted in one cassette..
+
+--- Page 4 ---
+Page 4 of 5 The specimen is received in formalin and labelled "Left hypogastric / obturator lymph nodes." It consists of a piece of yellow fatty tissue measuring 5 x 4 x 3 cm. There are multiple lymph nodes identified. The'largest piece measures 3 cm in. maximum dimension. Representtive sections are submitted in four cassettes. N  The specimen is received in formalin and labelled tLeft presciatic lymph. nodes." It consists of multiple pieces of yellow fatty tissue measuring 3 x 2 x 1 cm in aggregate. The specimen is entirely submitted in one cassette.. O: The specimen is received in formalin and labelled "Right presciatic lymph nodes." It consists of multiple pieces of yellow fatty tissue measuring 3 x 2 x 1. cm in aggregate. The specimen is entirely submitted in one cassette. P:  The specimen is received in formalin and labelled "Presacral lymph nodes." It. consists of multiple pieces of yellow fatty tissue measuring 4 x 2 x 1 cm in aggregate. There are muitiple iymph nodes identified. The specimen is entirely submitted in three cassettes. Q: The specimen is received in formalin and labelled rLeft proximal ureter." It consists of a segment of ureter measuring 2 cm in length and o.5 cm in diameter.. Representative sections are submitted in one cassette. R: The specimen is received in formalin and labelled "Right proximal ureter." It consists of a segment of ureter measuring 1.5 cm in length and 0.5 cm in diameter.. Representative sections are submitted in one cassette. SECTIONS : AFs: frozen section, right distal ureter all embedded. BFS: frozen section, left distal ureter all embedded. cFs: frozen section, urethral margin C1: right ureter C2 : left ureter C3 : right perivesical fat C4 : left perivesical fat C5 : peritoneal adhesion C6 : left bladder mucosa C7,8:  posterior bladder mucosa C9 : posterior bladder mucosa with diverticula. C10: trigone C11-16: bladder tumor C17: one lymph node. C18: right seminal vesicle and vas deferens C19: left seminal vesicle and vas deferens C20 : right apex C21 : left apex of the prostate C22 : right midprostate C23 : left midprostate with yellow lesion C24 : right anterior midprostate C25 : right posterior midprostate C26 : left anterior midprostate C27 : left posterior midprostate C28 : right anterior proximal prostate c29,30: right posterior proximal prostate C31-33: left proximal prostate from anterior to posterior. D1-4: multiple para-aortic lymph nodes E1,2:  multiple paracaval lymph nodes F: right common iliac lymph nodes G: left common iliac lymph nodes H1-3: right external iliac lymph nodes I: right lymph node of Cloquet  all embedded
+
+--- Page 5 ---
+Page 5 of 5 J1,2: multiple right hypogastric/obturator lymph nodes J3: portion of largest lymph node. J4 : one lymph node, bisected K1 : multiple left external iliac lymph nodes K2 : multiple lymph nodes K3 : portion of largest lymph node. L: left lymph node of cloquet all embedded M1-3: multiple left hypogastric/obturator lymph nodes. M4 : portion of largest lymph node N: left presciatic lymph nodes all embedded 0: right presciatic lymph nodes all embedded. P1-3: presacral lymph nodes all embedded Q: left proximal ureter R: right proximal ureter. MICROSCOPIC DESCRIPTION: A-R: See final microscopic-diagnoses. Signed by: ELECTRONIC SIGNATURE POST-OPERATIVE DIAGNOSIS: Same as preop PRE-OPERATIVE DIAGNOSIS: Muscular invasion Tcc bladder. ORDERING PHSYCIAN: Ordering Physician:
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diff --git a/output/text/557d8978-0e3e-4f31-bbde-896fb2e071b7.txt b/output/text/557d8978-0e3e-4f31-bbde-896fb2e071b7.txt
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index 0000000000000000000000000000000000000000..2d1cbfffec8f1049663f934ffe7f32dabdb363ac
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+UUID: E7D2AFFA-14B9-436F -B76F-C1F5B88D7600 tcga-gs-A9ty-0ia-pr Redacted AXILLAR LYMPH NODE: Tissue fragment of 7x5,3x4,3 cm. We identify a lymph node of 4x43,4 cm, that presents a pinky color with a whitish area that measures 3,8x3,3 cm Other three lymph nodes of pinky color are observed, that measure. 2,5x2,3x2,2 cm. LEFT AXILLAR LYMPH NODE, EXCISION: - DIFFUSE LARGE B-CELL LIMPHOMA WITH HIGH PROLIFERATIVE INDEX AnD pOSITIvITy fOR p53. The specimen corresponds to severa! lymph ganglions. One of them contains a diffuse large cell lymphoma which is positive for CD20, BCL6 and p53, and negative for BCL2, CD10 and MUM1. CD3 and CD5 show the presence of a scarce presence of intratumoral reactive T-cells. The KI67 proliferative index is 70%. The associated lymph nodes show a reactive follicular hyperplasia.. No rearrangement of the BCL2 gene by PCR (MBR) has been observed. ID-03 94$o13 Sute. synysh mid, aullo 0 773 FJ 3/3/14
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diff --git a/output/text/5584ad1d-e91c-42f5-b483-6aa260199dde.txt b/output/text/5584ad1d-e91c-42f5-b483-6aa260199dde.txt
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index 0000000000000000000000000000000000000000..f9df6e20561265810ae6ccc5dc6367048bdb561d
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+--- Page 1 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: FMP/SSN: Specimen #: DOb/Age/Sex: (Age: . F Race: WHITE Location: Taken: Physician(s) : Received: Reported: JCA-O-3 SPECIMEN: Cavinomna, nnfittnsAns ductl, nrs 85oc/3 A: SENTINEL LYMPH NODE #1 B: SENTINEL LYMPH NODE #2 SiH: srust,N0s c5o.9 C: SENTINEL LYMPH NODE #3 D: RIGHT BREAST 1/24/u h FINAL DIAGNOSIS: A. SENTINEL LYMPH NODE #1, EXCISIONAL BIOPSY: NEGATIVE FOR TUMOR BY H&E AND IMMUNOHISTOCHEMISTRY. B. SENTINEL LYMPH NODE #2, EXCISIONAL BIOPSY: RARE SINGLE CYTOKERATIN POSITIVE CELLS BY IMMUNOHISTOCHEMISTRY, NO GROUPS MEASURING MORE THAN 0.2 MM IN DIAMETER. C SENTINEL LYMPH NODE #3, EXCISIONAL BIOPSY: NEGATIVE FOR TUMOR BY H&E AND IMMUNOHISTOCHEMISTRY. D. BREAST, RIGHT, MASTECTOMY: INFILTRATING DUCTAL CARCINOMA, POORLY DIFFERENTIATED (BLOOM AND RICHARDSON GRADE: TUBULES=3, NUCLEAR PLEOMORPHISM=3, MITOSES=3, TOTAL scorE=9). TUMOR SIZE- 4.0 CM. NO DUCTAL CARCINOMA IN SITU IDENTIFIED. TUMOR 1.2 CM FROM DEEP MARGIN (NEAREST MARGIN). NO LYMPH VASCULAR INVASION IDENTIFIED. EXTENSIVE FIBROCYSTIC CHANGES CONSISTING OF FIBROSIS, ADENOSIS, SCLEROSING ADENOSIS, AND DUCT ECTASIA. COMMENT :  Immunostains for hormone receptors and HER 2 neu were performed on the previous biopsy with the following results: ESTROGEN RECEPTOR: NEGATIVE. PROGESTERONE RECEPTOR: NEGATIVE HER 2 NEU (BY HERCEPTEST): 1+ (NEGATIVE). The AJCc stage is pT2pN0(i+)MX. UUID:B1445681-4992-492D-AF85-4F975F20A2773 TCGA-A2-A04U-01A-PR Redacted Page 1 Continued on Next Page. FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 2 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: FINAL DIAGNOSIS (continued) : ** Report slogtronicallv Siqned Out ** CLINICAL DIAGNOSIS AND HISTORY: -year-old white female with T2mxnx right breast cancer. PRE-OPERATIVE DIAGNOSIS: Right breast cancer.. GROSS DESCRIpTION: A. Received fresh, labeled with the patient's name,. designated "SENTINEL LYMPH NODE #1 BIOPsy" is a single lymph node P, measuring 1.6 x 0.9 x 0.4 cm with an attached portion of fat. A portion of the lymph node is submitted for cBcp protocol.~The remaining tissue is submitted for microscopic examination. One cassette, none saved. B. Received in formalin, labeled with the patient's name, designated "SENTINEL LYMPH NODE #2" consists of a white/tan, somewhat fibrous tissue fragment consistent with a lymph node. Sectioning reveals a dense, white, fibrous nodule located within the specimen measuring 0.8 cm in its greatest dimension. No areas of hemorrhage or necrosis are identified. Entirely submitted. One cassette, none saved.. C. Receiued in formalin, labeled with the patient's name,. designated "SENTINEL LYMPH NODE #3" consists of a tan/orown, irreguiarly shaped tissue fragment measuring 2.5 x 2.0 x 1.5 cm. Sectioning reveals a tan/brown, unremarkable cut surface. Entirely submitted. Two cassettes, some saved. D. Received fresh, labeled with the patient's name,. designated "RIgHT BREAsT" is an 883.0 gram total mastectomy specimen, measuring 22.0 cm from the superior to inferior margin, 20.5 cm from the medial to the lateral, and 4.7 cm from the posterior margin. The overlying ellipse of nipple bearing skin measuring 4.6 x 4.2 cm and is without obvious scars or other abnormalities. An ink code is as follows: Blue-superior to anterior margin, green-inferior anterior margin, black-posterior margin. Sectioning reveals a well-defined, firm, tan tumor, measuring 4.0 x 3.2 x 2.5 cm in the mid anterior - left upper quadrant, approximately 1.5 cm from the deep margin. The remaining is mostly fatty with patches of white, fibrous tissue especially J tissue inferiorly. Multiple sections are submitted for the CBcp protocol.. Paraffin sections as follows: Page 2 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 Continued on Next Page.
+
+--- Page 3 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION (continued) : Dl: Skin and lateral tip. D2: Tumor. D3: Fibrous left lower quadrant. D4: Random section upper inferior quadrant.. D5: Random section upper most quadrant.. D6: Fibrous sections of the tumor.. D7: Section of nipple and underlying connective tissue. D8: Tumor deep margin. D9: Tumor deep margin. D10: Tumor deep margin. 10 CAssETTES Page 3 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974E End of Report.
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diff --git a/output/text/5591ad29-4fbd-45ce-bee7-a55c3dcc33fb.txt b/output/text/5591ad29-4fbd-45ce-bee7-a55c3dcc33fb.txt
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index 0000000000000000000000000000000000000000..575d02720a1b837849dbb1a9acb6b48821e5de48
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+--- Page 1 ---
+/Cs-0-3 HapuIo carcnoms 8179/3 ID#: Pathology Form Specimen Information Collected by: Date: Time Preserved by: Date. .ime: **.  SPECIMEN TYPE (# of samples provided) Frozen Paraffin Block Blood/Serum/Plasma Slide Diseased Normal Diseased Norma! Diseased Normal Diseased Norma! 4 2 4 2. 2 Time to LN2 Time to Formalin Time to LN2 12 min. 73 min min Primary Tumor Organ Size Extension of Tumor Distance to NAT LireR tumuR 5 l0 xg x7 cm cm Lymph Nodes Location # Examined # Metastasized Distant Metastasis Organ Detailed Location. Size Pathological Staging pT4 N o m o Stage: TL Notes: TCGA-CC-5260-01A-PR Redacted 4
+
+--- Page 2 ---
+ID#: Microscopic Description. : y lo. Histological Pattern. Cell Distribution + Structural Pattern +  Diffuse  Streaming  Mosaic Storiform Necrosis Fibrosis  Lymphocytic Infiltration  Palisading  Vascular Invasion  Cystic Degeneration  Clusterized Bleeding Alveolar Formation Myxoid Change  Indian File  Psammoma/Calcification y  s Cellular Differentiation : Squamous + Adenomatous Sarcomatous +- Lymphomatous  Squamoid Cell Glandular cell Round Cell Large Cell Spindle Cell Cell Stratification Fibroblast Small Cell  Keratin Secretion Osteoblast  RS Cell/RS Like  Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell  Pear! Gland formation Myoblast Plasma Cell Cellular Differentiation: Well Moderate Poor [X] .+ ++ Nuclear Appearance. Nuclear Atypia:  0 I I1 III  Aniso Nucleosis Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity Nuclear Grade: wIHC.Data Marker Result Value Date ER  Negative   Positive PR Negative  Positive Her-2/neu  Negative   Positive B-Cell Marker  Negative  Positive T-Cell Marker  Negative   Positive Other:  Negative   Positive Other: Negative   Positive Final Pathology Report Henalo cas cinoma Histological Diagnosis: Grade: ZZZ Comments: C Hepr(e ~c h0(anFic CaRci nomz ) Principal Investigator : Pathologist Date 5
+
+--- Page 3 ---
+COnsolIdateD diagnostic patholOgy form* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION STRUCTURAL PATTERN  Diffuse + Streaming.  Mosaic Storiform Necrosis  Fibrosis Lymphocytic Infiltration  Palisading Vascular Invasion kCystic Degeneration Clusterized Bleeding Alveolar Formation Myxoid Change Indian File Psammoma/Calcification 2. Cellular features: Squamous + Sarcomatous +- Lymphomatous Squamoid Cell Glandular cell Round Cell Large Cell Spindle Cell Cell Stratification 7 Fibroblast Small Cell Keratin Secretion R Osteoblast  RS CeIl/RS Like  Desmosome Intracyt. Vacuole  Lipoblast  Inflam. Cell Pear!  Gland formation  Myoblast Plasma Cell Otherwise Specified: J1$oJs Dr3 o2 Dz50Jp Dy 5OTo 2. Cellular Differentiation: Well Moderately Poor Nuclear Atypia: II HI Nuclear Appearance r Aniso Nucleosis Hyperchromatism  Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity X Nuckar Grade Histological Diagnosis: Heprts celly lak Caee>srg Cc 1 Comments: Date . PATHOLOGIST STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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diff --git a/output/text/5595ba72-ecc7-4b62-9059-3852ae7bacca.txt b/output/text/5595ba72-ecc7-4b62-9059-3852ae7bacca.txt
new file mode 100644
index 0000000000000000000000000000000000000000..47d06c17bcd6290e6023fcc12692f80518acee4b
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+
+--- Page 1 ---
+1Cs-0-3 Carcinoma,nfittnatng oluctl, N0s 85vof3 PcH Sitr: breast, uIQ c50.2 1/051 CQCF 9ih: busot,N0s C50.9 Diagnosis: 1. Poorly differentiated invasive ductal breast carcinoma with small areas of necrosis and secondary inflammation (tumor diameter 3 cm, margin distances: cranial 0.6 cm, caudal 0.4 cm, ventral 0.2 cm, dorsal 0.1 cm, medial 0.4 cm and lateral 0.8 cm). This results in the following summary tumor classification: invasive ductal breast carcinoma, NOS, G III, pT2 N0(0/3sn)L0V0R0. UUID:F2077079-D683-4D18-9489-84C760674AF6 TCGA-A8-A08I-01A-PR Redacted
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+** Case imported from legacy computer system. The format of this report does not match the original case. **. ** For cases prior to the section "SPEcIMEN" may have been added. ** DIAGNOSIS (A) TOTAL LARYNGECTOMY, LEFT SELECTIVE NECK DISSECTION LEVEL II, III, AND IV: SQUAMOUS CARCINOMA, WELL-DIFFERENTIATED, INVOLVING LEFT TRANSGLOTTIC REGION. THE TUMOR IS APPROXIMATELY O.5 CM IN GREATEST THICKNESS AND 3.7 CM IN GREATEST DIMENSION. No vascular invasion identified. Margins of resection free of tumor. No tumor present in 36 lymph nodes (0/17 Level 1I, 0/8 Level III, 0/11 Level IV). Thyroid, no tumor present.  report and diaqnosis completed by GROSS DESCRIPTION A) TOTAL LARYNGECTOMY, LEFT SELECTIVE NECK DISSECTION LEVEL IIIII, AND IV Overal1 9.0 x 7.0 x 5.0 cm laryngectomy with hyoid bone, thyroid gland, strap muscle and left neck dissection level II, IIi and Iv.. There is a 3.7 x 2.5 cm exophytic tumor in'the left transglottic area. The. tumor does not cross the midline anteriorly or posteriorly. The left thyroid 1obe is 4.5 x 3.0 x 1.5 cm. The right thyroid lobe is. 2.5 x 2.0  1.0 cm. The right thyroid lobe has an irregular latera1 edge. The thyroid gland is unremarkable. The tumor does not invade the anterior soft. tissues. INK coDe: Black - mucosal and tracheal margin. diagnosis; A3-A6, right pharyngeal margin from 12-6 o'clock (anterior to posterior), en face; A7-A10,'1eft pharyngeal margin from 6-12 o'clock (posterior to anterior, en face); A11-A27, entire tumor from right to left;. A28-A30, one bisected 1ymph node'in each; A31, two possible 1ymph nodes; A32-A34, four possible 1ymph nodes in each (A28-A34 are from 1evel II); A35-A39, one 1ymph_node bisected in each; A40, three possible 1ymph nodes (A35-A40 are from 1evel IIr); A41, A42, one bisected 1ymph node in each; A43, four possible 1ymph nodes; A44, five possible lymph nodes; level' Iv; A45, right thyroid lobe; A46, left thyroid lobe. *FS/DX:FSA, NO INVASIVE CARCINOMA AT MARGIN. SNOMED CODES Page 1 of 2 History Case Pathology History Case Pathology Report File under: Pathology
+
+--- Page 2 ---
+M-80703 T-24100 Page 2 of 2 History Case Pathology History Case Pathology Report File under: Pathology
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+FOR OFFIC IAL USE ONLY - PERSONAL DATA - PRIVACY ACT Or 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: FMP/SSN: DOB/Age/Sex: F Race: wHITE Taken: Location: Received: Physician(s) : Reported: ** AMENDED* * 1Cs-0-3 Carcnona, mifiltratng ductel Nos 85orf3 SPECIMEN: Sits: brlaot Nos c50.9 A: SENTINEL LYMPH NODE B: RIGHT BREAST TISSUE C: SUPERIOR MEDIAL BORDER 1/24/n h FINAL DIAGNOSIS: A. SENTINEL LYMPH NODE, BIOPSY:  1 LYMPH NODES NEGATIVE FOR TUMOR BY H&E. - NEGATIVE FOR CYTOKERATIN BY IMMUNOHISTOCHEMISTRY. B. BREAST, RIGHT, LUMPECTOMY: INFLITRATIVE DUCTAL CARCINOMA WITH CRIBRIFORM PATTERN, WELL DIFFERENTIATED. 1 CM. SIZE:  MARGINS NEGATIVE.  NEAREST MARGIN, SUPERIOR, 2.0 MM - NO LYMPHVASCULAR SPACE INVASION IDENTIFIED. - FIBROCYSTIC CHANGES TO INCLUDE FIBROSIS, CYSTS, AND APOCRINE METAPLASIA. MICROCALCIFICATIONS ASSOCIATED WITH BENIGN AND MALIGNANT BREAST TISSUE. -AJCC T1bNOMx. C.  SUPERIOR MEDIAL BORDER TISSUE, EXCISION:  BENIGN FIBROFATTY CONNECTIVE TISSUE. k* Report Electronically Signed Out * CLINICAL DIAGNOSIS AND HISTORY: -year-old white female with right breast cancer. PRE-OPERATIVE DIAGNOSIS: UUID:454CB5E9-3778-4666-9CED-913E08CB3615 Right breast cancer. TCGA-A2-A0EM-01A-PR Redacted Page 1 e'age FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 2 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION: A. SENTINEL LyMPH NODE received fresh and consists of multiple irregular fragments of tan/yellow soft tissue measuring 3.0 x 2.0 x 0.5 cm in aqareaate. The specimen is submitted in its entirety in two cassettes. B. RIgHT BREAsT TIssUE received fresh and consists of a 9.0 x 6.5 x 2.3 cm piece of fatty tissue oriented with sutures (one-medial, two-superior, three-anterior). Ink code: Red-medial and lateral, blue-superior, green-inferior, yellow=anterior, black-posterior. Sectioning reveals a 0.6 cm white/tan, ovoid mass with gritty cut surface, on sectioning-3.0 mm from superior/posterior margin. The remaining tissue is mostly fatty with admixed patches of white fibrous tissue. One section of each tumor and grossly normal fibrous tissue harvested for cbcp protocol; mirror images for Histology in cassettes B1 and B3 respectively. B2 tissue adjacent to tumor in the same plane. Additional representative sections are submitted in sequential order in 15 cassettes, the following pairs of cassettes representing one section in multiple cassettes: B4-B5, B7-B8, B9-bl1. B7 and B8, and B9-Bll are tissue on either side of tumor. C. SUPERIOR MEDIAL BORDER received in formalin and consists of one irregular shaped fragment of tan/yellow, lobular, fibrofatty adipose tissue measuring 3.0 x 2.4 x 1.5 cm. Orientation is not provided. The specimen is inked and serially section to reveal a yellow, lobular,. glistening cut surface with no well-defined lesions or nodules identified. The specimen is submitted in its entirety in sequential order in three cassettes. Page 2 End of Report FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
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diff --git a/output/text/563732ab-cc40-4ecd-a1b8-917f729e9d59.txt b/output/text/563732ab-cc40-4ecd-a1b8-917f729e9d59.txt
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+UUID:82168837-DCF3-4E7F-A72A-212655F394F08 TCGA-AN-A0XU-01A-PR Redacted TSS Patient ID Case #: JOB: Sex: Female Ethnicity (Race. Cancer Sample Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma. Date of Procurement:. Anatomic Site: Breast Tumor location: Primary. Tissue Specification: Tumor Specinen Matrix: Tissue Specimen Format: OcT Container: block Type of Procurement: surgery Grade: 3 T Stage: 2 N Stage: 0 M Stage: 0 Treatment: none. Treatment Details: n/a. Normal Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw. Matrix: Blood Specimen Format: frozen Container: tube Date of Procurement: 1c0-0-3 carcinuma.vifiltratrg duct, Nos 85vc/3 Sih: brast, Nos c5o.9 h 10/21
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diff --git a/output/text/5639c325-7287-4d17-b257-d450672d735f.txt b/output/text/5639c325-7287-4d17-b257-d450672d735f.txt
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index 0000000000000000000000000000000000000000..572b5aede0ce42829b6733c46dcd0d52113c015e
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+FINAl DiaGnOSIS: Part 1: breast, right..needle Localized Segmental mastectomy -- A  inVaSIVE DUCtaL CARCinQmA, 1.9 Cm (GROSS), NOTTInghAm GRADE 2 (COmBINeD nOTTinGhAm SCORE 6/9: TUbULE fORmATiON 3/3, nUCLEAR ATyPIA 2/3, MITOTIC ACTiVITy 1/3). B. DUctAl CArcINOma IN SitU, EXTeNSIVE, SOLiD TYpe nUCLEAR GRADE 2, WITh LOBULAR CANCERIZATION AND FOCAL COMEDO TYPE NECROSIS, ASSOCIATED WITH INVASIVE TUMOR ANDE COmpRISES mOrE tHAn 25% Of tumOR VOlUmE. C. LYMPHOVASCULAR INVASION IS IDENTIFIED. D.  MARGINS FREE, CLOSESt ANTERIOR WITHIN 0.4 Cm, SECOND CLOSESt POStERiOR WITHIN 0.5 CM. E. SCLEROSING ADENOSIS. F. FIBROADENOMATOID CHANGES. G.  BIOPSY SITE CHAnGES. H. PATHOLOgIC StAgE (see comment). PARt 2: SENTInel Lymph NODe numbER 1, BIOpSy - ONE LYMPH NODE, NEGATIVE FOR METASTATIC CARCINOMA (0/1). part 3: sentinel Lymph node number 2, biopsy - ONE LYMPH NODE, NEGATIVE FOR METASTATIC CARCINOMA (0/1). CASE SYNOPSIS: Ics-0-3 SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST Carcvoma, infitnutny duc+l, nos 85o0|3 LATERALITy: Right Procedure: Sih: buist,Nos c5v.9 3/nfu h  Segmental LOcATIOn: Not specified SIZE OF TUMOR:  Maximum dimension invasive component: 1.9 cm. MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: TUMOR TYPE (invasive component): No Ductal adenocarcinoma, NOS NOTTinGhAm SCORE: Nuclear grade: 2 Tubule formation: 3 Mitotic activity score: 1 Total Nottingham score: 6 Nottingham grade (1, 2, 3): 2 ANGIOLYMPHATIC iNVASION: Yes DERMAL LYMPHATIC INVASION:  Not applicable CALCIFICATION: No TumOr type, In SItu: Solid Percent of tumor occupied by in situ component: 35 %. SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No SURG MARGINS INVOLVED BY IN SITU COMPONENT: No LYMPH NODES POSITIVE: LyMPH nODES EXAMINED: 2 METHOD(S) OF LYMPH NODE EXAMINATION:  H/E stain t Stage, patholOgiC: pT1c N Stage, pathologiC: pN0 m Stage, PatholOgIC: pMX ESTROGEn ReCEPTORS: positive PROGESTERONE RECEPTORS: positive HER2/NEU: 2+ UUID:C7476828-0040-4013-8D30-06935E3FB8970 TCGA-BH-A0HB-01A-PR Redacted 3f13/n
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diff --git a/output/text/565da2fe-74eb-49f5-a170-8488c0990f77.txt b/output/text/565da2fe-74eb-49f5-a170-8488c0990f77.txt
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index 0000000000000000000000000000000000000000..66f0586c524a7c6766df340546fedcc44e397302
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+UUID:F969E3E4-0053-44E9-858C-8EFD8D62C512 TCGA-A7-A425-01A-PR Redacted Final Surgical Pathology Report Procedure: Diagnosis A.  Lymph node, right axillary sentinel node, excision: One lymph node positive for metastatic carcinoma (l/1). Breast, right, excision: Invasive lobular carcinoma (see tumor characteristics in the microscopic description). Lymph nodes, right axillary contents, excision: Ten of sixteen lymph nodes positive for metastatic carcinoma (10/16). D. Lymph node, highest apical node, excision: One of two lymph nodes positive for metastatic carcinoma (l/2). Microscopic Description: 1co 3 Invasive carcinoma: Histologic type: Lobular cascinxna, inF1tati ng: lOkuIar, NOS Histologic grade: Overall grade:2 8s2q3 Architectural score: 3 5ik: bre9sh n>>S C5O.9 Nuclear score: 2 Mitotic score: 1 7-23+30 Greatest dimension (pT) 7.5 cm, pT3 excision and 1 cm from the superficial soft tissue margin. Vessel invasion: Present Nipple (Paget's).  Tumor invades into the dermis beneath the surface of the nipple: Paget's disease is not identified. Ductal carcinoma in situ: Not identified Description of non-tumorous breast: Biopsy site changes are identified. Fibrocystic changes. Lymph nodes:.  Number of positive nodes of total: Twelve lymph nodes positive for metastatic carcinoma (12/19). Size of largest metastasis: 2.9 cm Extracapsular extension (present/absent): Present pN: pN3a Distant metastasis (pM): pMX Prognostic markers: Previously performed Specimen A. Right breast axillary sentinel node. B.  Right breast stitch at 12 o'clock C. Right axillary contents D. Highest apical node
+
+--- Page 2 ---
+Clinical Information Right breast cancer Intraoperative Consultation A) Lymph node, right axillary sentinel node, excision: One lymph node positive for metastatic carcinoma (l/l). Gross Description. A. Received fresh labeled "right axillary sentinel node hot not blue" is a lymph node that measures 2.9 x 1.7 x 1.4 cm in dimension. The lymph node has a firm consistency and shows yellowish discoloration. representative section from the node is submitted for frozen section. The remaining node is sectioned and entirely submitted for permanent section in 6 cassettes. B. Received fresh for tissue procurement labeled "right breast" is a 1220 g, 29.0 cm (medial to lateral) by 23.5 cm (superior to inferior) by 5.8 cm (anterior to posterior) soft, lobulated tan gold-like portion. of fibroadipose tissue in keeping with breast, designated as right per requisition slip and container and oriented by a suture as stated flat 1.3 x 1.3 cm nipple is present along the anterior aspect. An indurated focus is present subjacent to the central superior portion of the skin, corresponding to the junction of the upper inner and outer quadrants. The anterior surface in this area is inked blue. The There intact deep margin is inked black and the specimen is sectioned. is a central, 7.5 cm (superior to inferior) by 5.5 cm (medial to lateral) by 4.0 cm (anterior to posterior) rubbery tan-white apparent tumor mass is present (corresponding to the central junction of the 4 quadrants). The lesion is present within 3.5 cm of the inked deep margin and appears to approach the anterior surface to within 2 cm.. A portion of tumor and a portion of normal parenchyma are submitted for tissue procurement as requested. The cut surfaces throughout the remainder of the specimen consist predominantly of soft iobulated tan gold adipose tissue with a scant amount of interspersed delicate tan-white fibrous +issue.  No additional mass lesion or abnormality is identified. Summary: 1 - deep margin subjacent to the lesion, 2 - lesion to anterior surface, 3 through 7 - lesion to adjacent parenchyma, 8 - random upper outer quadrant, 9 - upper inner quadrant, 10 - lower inner auadrant, 11 - lower outer quadrant, 12 - nipple c. Received fresh and subsequently fixed in formalin labeled "right axillary contents "is a 12.0 x 7.5 x 3.0 cm aggregate of yellow lobular fatty tissue fragments which are not orientated. The specimens are palpated to identify lymph nodes which range from 0.1 cm and 2.5 cm in greatest dimension.. The lymph nodes are entirely submitted as follows: 1 possible lymph node,  2 - 6 possible lymph nodes, 3 - 6 possible lymph nodes, 4 - 2 possin'e lymph nodes, 5 - 1 possible lymph node, 6 - 1 possible lymph node.. D. Received fresh and subsequently fixed in formalin labeled "highest apical node "is a 3.0 x 2.0 x 0.4 cm aggregate of yellow lobular fatty nodes present. The lymph nodes are 0.5 cm and 0.2 cm in greatest dimension. The specimens are entirely submitted as follows: 1 - lymph nodes, 2 - remaining fat. Criteri
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diff --git a/output/text/5668a771-08a1-42ef-9dd8-9a9809abf869.txt b/output/text/5668a771-08a1-42ef-9dd8-9a9809abf869.txt
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index 0000000000000000000000000000000000000000..5466eb99ff6e2033c9969d4347517c182a435fca
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+UUID:6EEF1F11-603E-4196-91AB-724BBEE20CE7 TCGA-EW-A6SB-01A-PR Redacted Surgical Pathology Report Name: xxxx Case #: x DOb: Collected: Gender: F Received: x MRN: x Reported: + Location: x Physician: x Pathologic Interpretation: tCDo-3 Aeims yre iyiltiatiicycluctnDs A. LEFT AXILLARY #1 85013 Negative for carcinoma, four lymph nodes examined (0/4). Keratin immunostain is pending. YJ 7/Q4/13 B. LeFt AXILLARY, ,PalpaBLE  Negative for carcinoma, four lymph nodes examined (0/4) Keratin immunostain is pending. C. Left segmental mastectomy: INVASIVE DUCTAL CARCINOMA, poorly differentiated, Nottingham grade 3 (3+3+3=9), 3.1 cm in greatest dimension. Immunohistochemical studies performed on previous biopsy showed the following results: Estrogen Receptor:. NEGATIVE (< 1%) Progesterone Receptor:NEGATIVE (< 1%)  Her2/neu  NEGATIVE (0) Androgen Receptor:  NEGATIVE EGFR: POSITIVE GCDFP: NEGATIVE HLA-DR: Immunohistochemistry is pending Skin is uninvolved by tumor.  Resection margins are uninvolved by invasive carcinoma; the tumor is at less than 1 mm from the deep resection margin.  Negative for lymphatic space invasion.
+
+--- Page 2 ---
+SURGICAL PATHOLOGY CANCER CASE SUMMARY Procedure Excision without wire-guided localization. Lymph Node Sentinel lymph node(s) Specimen Laterality Left Histologic Type of Invasive Carcinoma Invasive ductal carcinoma (no special type or not otherwise specified) Tumor Size: Size of Largest Invasive Carcinoma Greatest dimension of largest focus of invasion >1 mm: 31 mm Histologic Grade: Nottingham Histologic Score.  Glandular (Acinar)/Tubular Differentiation  Score 3: <10% of tumor area forming glandular/tubular structures Nuclear Pleomorphism  Score 3: Vesicular nuclei, often with prominent nucleoli, exhibiting marked variation in size and shape, occasionally with very large and bizarre forms Mitotic Rate Score 3 (8 mitoses per mm?) (see Table 1) Overall Grade Grade 3: scores of 8 or 9 Tumor Focality Single focus of invasive carcinoma. Ductal Carcinoma In Situ (DCIS) No DCIS is present Lobular Carcinoma In Situ (LCIS) Not identified Margins  Invasive Carcinoma  Margins uninvolved by invasive carcinoma. Distance from closest margin: 1 mm Specify margin: Deep Lymph Nodes Number of sentinel lymph nodes examined: 8 Total number of lymph nodes examined (sentinel and nonsentinel): 0 Number of lymph nodes without tumor cells identified: 8 Method of Evaluation of Sentinel Lymph Nodes. Hematoxylin and eosin (H&E), 1 level Immunohistochemistry Treatment Effect: Response to Presurgical (Neoadjuvant) Therapy In the Breast  No known presurgical therapy. In the Lymph Nodes  No known presurgical therapy. Lymph-Vascular Invasion. Not identified Dermal Lymph-Vascular Invasiond Not identified Pathologic Staging (based on information available to the pathologist) (pTNM) Primary Tumor (invasive Carcinoma) (pT) pT2: Tumor >20 mm but 50 mm in greatest dimension.  Regional Lymph Nodes (pN) pNO:  No regional lymph node metastasis identified histologically Distant Metastasis (pM)  Not applicable
+
+--- Page 3 ---
+Ancillary Studies Performed on another specimen. Specify specimen (accession number): xxx Estrogen Receptor (ER) Results and interpretation: Negative (<1% of tumor cells with nuclear positivity) Progesterone Receptor (PgR) Results and interpretation: Negative (<1% of tumor cells with nuclear positivity) HER2 Immunoperoxidase Studies Results: Negative (Score 0) AJCC Classification (7t edition): pT2, pN0, pMn/a Procedures/Addenda: Addendum Date Ordered: Status: Date Complete: Date Reported: Addendum Diagnosis A. LEFT AXILLARY #1 Keratin immunohistochemistry is negative B. LEFt AXILLARY, PALPABLE: Keratin immunohistochemistry is negative.. Final AJCC Classification (7t edition): pT2 (sn)N0(i -) Mn/a Addendum Diagnosis ADDENDUM C: Immunohistochemistry for HLA-DR is positive in tumoral cells. This neoplasm is consistent with an invasive ductal carcinoma, medullary type. Intraoperative Consultation:. A. Left axillary #1,. . FS: No malignancy seen B. Left axillary . palpable, FS1-3: No malignancy seen.. X Clinical History:. Patient with palpable breast cancer, please evaluate margins and lymph nodes.
+
+--- Page 4 ---
+Operation Performed: Left segmental mastectomy with sentinel lymph node biopsy, possible axillary node dissection Pre Operative Diagnosis: Carcinoma left breast Specimen(s) Received/Processing Information:. Fee Codes:. A: LEFT AXILLARY #1 FS Frozen section x 1, FS Perm x 1, Touch Prep. Histology x 1, FSDeep 1 x 1, Cytokeratin Cocktail (KER) x 1, H&E, initial x 1 A: B: B: LEft AXIllAry, , PALPABLE FSFrozen section x 1, FS Perm x 1, Touch Prep Histology x 1, Cytokeratin Cocktail (KER) x 1, Frozen section x 1, FS Perm x 1, C: Cytokeratin Cocktail (KER) x 1, Frozen section x 1, FS Perm x 1, Cytokeratin Cocktail (KER) x 1, H&E, Initial x 1, Cytokeratin Cock. C: Left segmental mastectomy (1 Suture -supeior, 2 Sutures - medial) H&E, Initial x 1, H&E, Initial x 1, H&E, initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, HLA-DR (IP) x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Gross Description: A.Received fresh labeled "Left axillary #1,. . FS" is a fragment of adipose tissue that measures 5 x 4 x 2 cm. There are four palpable lymph nodes present. The lymph nodes are bisected and submitted for frozen section (cassette #1Fs). Representative sections of the remaining adipose tissue are submitted in cassette #2. B.Received fresh labeled "Left axillary ..  palpable, FS" is a fragment of adipose tissue that measures 4 x 4 x 2 cm. There are four palpable lymph nodes present. The lymph nodes are bisected and submitted for frozen section in cassettes #1-3Fs. The rest of the specimen is submitted in cassettes #4-8. C.Received in formalin labeled "Left segmental mastectomy (1 suture -superior, 2 sutures --medial)" is a lumpectomy specimen weighing 120 grams and measuring 9 x8 x 3.5 cm, with an unremarkable dark skin ellipse measuring 3.3 x 1.3 cm. The specimen is inked as follows: superior-blue, inferior-green, anterior-yellow, deep-black, medial- red, lateral-orange. Upon sectioning, there is a 3.1 x 3.0 x 3.0 cm well circumscribed, nodular tumor, white-tan, with. an elastic consistency and central cavity. A metallic clip is identified in the central of the tumor. The tumor is grossly. at less than 0.1 cm from the deep margin, 0.4 cm from the superior margin, 1.0 cm from the lateral margin, 2.0 cm  from the medial margin, 2.5 cm from the anterior and skin margin, 4.0 cm from the inferior margin. The rest of the specimen has a cut surface, yellow-tan and homogeneous. Cassettes are submitted as follows: Cassette #1 Tumor in relation with deep and superior margins. Cassette #2 Medial margin Cassette #3 Lateral margin. Cassette #4 Anterior margin (and skin) Cassette #5 Inferior margin. Cassette #6 Area of tumor with clip Cassettes #7&8 8Composite section of the tumor. Cassettes #9-12 Additional sections of the tumor Cassettes #13-15 Representative sections of the rest of specimen.
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+TDO-3 Cocinom, nnal cQl UUID:1B881218-C0F8-4717-88E2-CAF9D1BFEA95 TCGA-UW-A7GN-01Z-PR Redacted Cluomkhsbe Type 8317|3 Site D%idneyNoS C64.9 Surgical Pathology Report S9/24/13 Diagnosis: Kidney, left, laparoscopic nephrectomy - Renal cell carcinoma, chromophobe type, grade 2 (of 4, Fuhrman classification), 3.6 cm diameter, without angiolymphatic invasion, with focal extracapsular extension, inked surgical margins not involved. Clinical History:  yo male presents with a left kidney mass. Gross Description: Specimen fixation: formalin Type of specimen: laparoscopic nephrectomy Side of specimen: left Size and weight of specimen: 17 x 16 x 4 cm; 610 grams Presence/absence of adrenal gland: absent Tumor description/site: The tumor site is left upper pole/posterior surface; it is a circumscribed Iobulating appearing tan/orange mass with focal bands of white fibrosis. The surface overlying the mass is inked green. The hilar structures are inked purple. Tumor size: 3.6 x 3.3 x 2.8 cm Presence/absence of multicentricity: absent, one focus Confinement/non-confinement to the kidney: confined but abutting the renal capsule Extent of invasion: Perirenal adipose tissue: does not grossly involve Gerota' s fascia: does not grossly involve Renal vein: does not grossly involve. Ureter: does not grossly involve. Other organs: n/a Surgical margins: Perirenal adipose tissue: negative grossly
+
+--- Page 2 ---
+Renal vein: negative grossly Renal artery: negative grossly Ureter: negative grossly Description of kidney away from tumor: slightly hemorrhagic appearing Lymph nodes (hilar): none identified Other significant findings: none Tissue submitted for special investigations:. Digital photograph taken: No Block Summary: A1 - ureter margin A2 - hilar vessels. A3 - uninvolved kidney A4-A6 - tumor at green ink A7 - tumor with adjacent normal. A8 - tumor with adjacent normal A9 - additional tumor Light Microscopy: Light microscopic examination is performed by Dr.. Histologic tumor type/subtype: Renal cell carcinoma, chromophobe type CD10(+), CK7(+), Colloidal iron(+). Dr. concurs. Histologic grade (if applicable): Grade 2. Tumor size (greatest dimension): 3.6 cm. Extent of tumor invasion: Capsular invasion/perirenal adipose tissue: Present (block A7) Gerota' s fascia: Not present. Renal vein: Not involved Ureter: Not involved Venous (large vessel) Not involved. Lymphatic (small vessel): Not involved Depth of invasion: N/A Adjacent organs: Not received.
+
+--- Page 3 ---
+Histologic assessment of surgical margins: Perirenal adipose tissue: Negative Gerota' s fascia: Negative Renal vein: Negative Renal artery: Negative Ureter: Negative Adrenal gland: Not received Lymph nodes: Not received Other significant findings: None AJCC Staging: pT3a pNx pMx J 8/31[13
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diff --git a/output/text/5698fa88-fdc0-40d2-b3e9-0783fa6f327e.txt b/output/text/5698fa88-fdc0-40d2-b3e9-0783fa6f327e.txt
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+JCA-0-3 Carciom,nfiltratrng /obulr, Nos 8520/3 Siti : Brast, Nos cs0.9 15 Diagnosis: 1. Ablated breast sample with a moderately differentiated invasive lobular carcinoma (tumor diameter: 8 cm). Tumor-free dorsal resection margin. This results in the following tumor classification for the'right breast: lobular carcinoma, G II, pT3N0L0V0R1. UUID: DF890966-D14E-4EDF-B6E3-E10E40BA5B5D Redacted TCGA-A8-A09Z-01A-PR
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diff --git a/output/text/56b6585f-ee34-4b78-850a-fb41e52c44d9.txt b/output/text/56b6585f-ee34-4b78-850a-fb41e52c44d9.txt
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index 0000000000000000000000000000000000000000..660b64dca60ee75ded4c65b6e80357d5fc454cb7
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+UUID:ACEB9450-95DD-483A-A7FD-99EA223597850 TCGA-WC-A87U-01A-PR Redacted Accession: Specimen Date/Time: DIAGNOSIS 790 (A) RIGHT GLOBE, ENUCLEATION: CHOROIDAL MELANOMA, PREDOMINANTLY SPINDLED TYPE B (18 MM BASE) EXTENDING TO INVOLVE THE CILIARY BODY. See comment. THE TUMOR INVADES NEARLY FULL THICKNESS SCLERA, IN A PERINEURAL PATTERN Extraocular extension is not identified.. Vortex vein invasion is not identified.. The optic nerve is uninvolved by tumor.n. Retinal detachment associate with the tumor. Lens with nuclear sclerosis. Entire report and diagnosis completed by. COMMENT The tumor is predominately amelanotic, consisting of a spindled morphology. Mitotic count is 2 per 10 high power fields. Foca complex vascular loops are identified by PAS. Numerous levels were examined as the tumor extensively invades the sclera and approaches but does not extend extraocularly. The tumor is positive for pan-melanoma markers (MART1, HMB45, tyrosinase) and negative for synaptophysin, consistent with the diagnosis of melanoma.. eB 87243 CONSULTANT(S) 069.8 y J i/i6(14 GROSS DESCRIPTION (A) RIGHT GLOBE - An intact right eye (22.0 mm AP x 24.0 mm horizontally x 21.0 mm vertically) and attached optic nerve (7.0 mm in length). The cornea is transparent (12.0 mm horizontally x 11.0 mm vertically), anterior chamber is visible, encompassed. by an irregular green-brown iris (6.5 x 8.0 mm in diameter). At the 2-4 o'clock position of the iris, a mass is present along the limbus. The sclera is unremarkable. On transillumination, a shadow is present from 2-4 o'clock extending from the iris and limb. to 0.2 mm from the optic nerve. The superior calotte is removed first for tissue harvest. The vitreous is clear. The tan tumor (18. 11 x 6 mm in height) is loosely attached to the sclera with a loosely adherent retina over the surface of the tumor. SECTION CODE: A1, superior temporal vortex vein; A2, superior nasal vortex vein; A3, inferior nasal vortex vein; A4, inferior temporal vortex vein; A5, pupil optic nerve section; A6, superior calotte; A7, inferior calotte; A8, loose portion of tumor.. CLINICAL HISTORY Choroidal melanoma, right eye. SNOMED CODES T-AA000, M-87203 *Some tests reported here may have been developed and performance characteristics determined by. These lests have not been specifically cleared or approved by the U.S. Food and Drug Administration. Released by: -END Of REPORt-
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diff --git a/output/text/56dcda9c-6c8b-4e4a-8ca9-9188fac4a611.txt b/output/text/56dcda9c-6c8b-4e4a-8ca9-9188fac4a611.txt
new file mode 100644
index 0000000000000000000000000000000000000000..bbf94f2c14d3ee14a2f2d8c3ffc073af0288db61
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+1cs-0-3 117J Caucniont, duct1,N0s 85oo|3 hw S,f Gse : busF,Nss cso.9 m Collection Date: Sex: Date of Birth: Order Doctor: Not for patient's chart. *DIAGNOSIS ORIGINAL TEXT: FEMALE BREAST, RIGHT RIGHT BREAST MASS; MULTIFOCAL INTRADUCTAL AND INFILTRATING DUCTAL CARCINOMA, GRADE 2/3, NUCLEAR GRADE MODERATELYS DIFFERENTIATED, THE TUMOR EXTENDS TO WITHIN O.IMM OF THE SURGICAL MARGIN. ORIGINAL VER ID AT 00:00 BY *** End of Report UUID:FA43414D-3757-43CC-8949-77F82DF4FA4D0 TCGA-B6-A0I5-01A-PR Redacted
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diff --git a/output/text/56f56c14-5ab9-46a9-8e1e-f6e4a1280350.txt b/output/text/56f56c14-5ab9-46a9-8e1e-f6e4a1280350.txt
new file mode 100644
index 0000000000000000000000000000000000000000..efc814a1dfdb74d6a1f26734473cf39b3c81097a
--- /dev/null
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+--- Page 1 ---
+Surgical Pathology Report * Revised * Case #: Name: Collected: DOb: Received: Gonder: Reported: mrn: Copy To: Location: Physician: Pathologic Interpretation: Amendment tO pathOlOgic interpRetation (Specimen "e") 1cs-0-3 A. Left breast sentinel node #1, FS: 8520/3 - One lymph node, no tumor seen (0/1). Caiciione, nifttnaHny lobuinr Nos SiF;5uust, Nos C50.9 3/1fn h B. Sentinel node #2, FS: - One lymph node, no tumor seen (0/1).. c. Left sentinell node #3, FS: - One lymph node, no tumor seen (0/1). D.  Left breast with one stitch superor and two lateral:. - Multifocal infiltrating lobular carcinoma, (two largest nodules are 2.5 cm and 2 cm in greatest dimenslon), margins free. - Extensive lobular carcinoma in situ, margins tree. See comment.. - Fibrocystic changes.. E. Sentine! node #4, FS: - Metastatic carcinoma to one out of two lymph nodes (1/2). See Comment.d Comment The keratin stain on the lymph node shows metastatic carcinoma.d The keratin stains on the remalning sentinel lymph nodes (A,B,C, F, G, and I) are negative. Keratin stains were also performed on all of the axillary content lymph nodes and they are negative.. Previousty reported as:. E. Sentinel node #4, FS:. - Two iymph nodes, no tumor seen (0/2). UUID:6197798C-6F04-470E-BA91 922548E2DFAF TCGA-EW-A1PG-01A-PR Redacted F. Sentinel node #5, FS: - One lymph node, no tumor seen (0/1). G. Sentinel node #6, FS: - One lymph node, no tumor seen (0/1).. H. Left sentinal node #7, FS: - Metastatic carcinoma to one out of one lymph node (1/1). I. Non sentinel node: - Three lymph nodes, no tumor seen (0/3). J. Left axillary content:  - Sixteen lymph nodes, no tumor seon (0/16).. Comment (D): ). The tumor cells on that speqimen were. The patient has a previous history of infiltrating lobular carcinoma (. are positive for estrogen and progesterone receptors, but were negatve tor Her2 FiSH. Two nodules of infilttating. carcinoma are present. In addition, there are multipie focal microscopic nodules of infiltrating carcinoma. Keratin stains are pending on the negative sentinel lymph nodes. In specimen H, the metastasis to the lymph node is 0.4 |cm in. greatest dimension.
+
+--- Page 2 ---
+SURGICAL PATHOL Report Iumor Summary: Specimen Type: Mastectomy Lymph Node $ampling: Sentinel lymph node with axillary dissection. Latorallty: Lef Tumor Site: Lower outer quadrant Size of Invasive Component: Greatest dimension: 2.5 cm (largest nodule) Additional dimensions: 1.5 x 1.5 cm Histologic Type: Invasive lobular Lobular carcinoma in situ Histologlc Grade: Tubule Formation: Minimal less than 10% (score = 3) Nuclear Pleomorphism: Small regular nuclei (score = 1) Mitotic Count: Less than 10 mitoses per 10 HPF (score = 1) Total Nottingham Score: Grade I: 3-5 points Regional Lymph Nodes: Number examined: 25 Number involved:1 (malignant focus is 0.4 cm in greatest dimension). Margins: Margins uninvoived by invasive carcinoma. Distance from closet margin: 1.5 cm. Specify which margin: Deep Venous/Lymphatic (Larga/Small Vessel) Invaslon (V/L): Absent Pathologlc Staging: pT2 (see below), pN1a, pMX The stage is based on adding the size of the two largest nodules which are 2.5 and 2 cm in greatest dimension. NOTE:Sm  anatyte spectfic rragents (ASRs) validosed by our laboratory. These ASRs a IDS-ER, PgR 636-PR. A425-Hs pathoiogis as positive o' negn: Its are resd by a As the attending pathologist, I attest that I: (i) Examined the relevant preparation(s). for the specimen(s): and (1i) Rendered the diagnosis(es). MD ***Electronically Signed Out By**** Amendments Amended: Reason: Review of case with diagnosis change Previous Signout Date: Intraoperative Consultation A. Left breast sentinal node #1: No tumor seen.. B.Sentinal node #2: No tumor seen. C. Left sentinal node #3: No tumor seen. D. Left breast with one stitch superior and two lateral: E.  Sentinal node #4: No tumor seen. F. Sentinal node #5: No tumor seen. Page 2 of 4
+
+--- Page 3 ---
+SURGICAL PATHOL Report G. Sentinal node #6: No tumor seen on touch prep. H. Left sentinal node #7: Cellular evidence of metastatic carcinoma on touch prep.. Clinical History: None Provided Operation Performed Left breast lymph node dissection/mastectomy Pre Qperativo Dlagnosis: Left breast mass Specimen(s) Received: A: Left breast sentinel node #1, FS B: Sentinel node #2, FS C: Left sentinell node #3, FS D: Left breast with one stitch superior and two lateral E: Sentinel node #4, FS F: Sentinel node #5, FS G: Sentinel node #6, FS H: Left sentinal node #7, FS I: Non sentinel node J: Left axillary content Gross Description: A. Received fresh is a tan soft lymph node, measuring 1.2 x 1.0 x 0.5 cm. Bisected and submitted in toto in ohe cassette for frozen section. B. Received fresh is sentinel lymph node is a tan soft lymph node, measuring 1.0 x 1.0 x 0.5 cm. Bisected and submitted in toto in one block for frozen section. c. Received fresh is a tan soft lymph node, measuring 0.8 x 0.6 x 0.6 cm. Submitted in toto in one block for frpzen section.. D. Received in formalin is a mastectomy specimen, weighing 382 grams, measuring 15.0 x 13.0 x 4.0 cm. Tha specimen is. oriented with one stitch superior, two stitches lateral. At the anterior aspect of the spocimen, there is one tan ellipse of skin, measuring 4.0 x 3.0 cm.  Centrally located is a pink, unremarkable areola with unremarkable nipple, 10 cm in. diameter. The areola measures 2.5 x 2.0 cm. The resection margin is inked black. Cut section shows ong ix-denined. tan, Arm lesion located at 4 to 5 o'clock, measuring 2.5 x 1.5 x 1.5 cm. The lesion is located at the iower outer quadrant, 1.5 cm away from the deep margin, 9.0 cm away from the superior margin, 2.0 cm away from the inferior margin, 2.5 cm away from the lateral margin, 10.0 cm away from the mediai margin.  Also present is ill-defined fibrotic lesidn, measuring 2.0 x 1.5 x 1.5 cm located at 7 to 8 o'clock.The lower inner quadrant, the second lesion is 2.0 cm away from the deep margin, 9.0 cm away from the superior margin, 1.5 cm away from the inferior margin, 7.0 cm away from the lateral margin. 3.0 cm away from the medial margin. The remaining parenchyma is yellow, iobulated, adipose tissue, mixeg with tan, firm,. fibrotic tissue. The ratio is approximately 80-20%. Sections submitted as follows: 1 Section from the nipple 2 Superior margin 3 inferior margin 4 Lateral margin 5 Mediat margin 6 Deep margin 7-12 Lesion at 5 and 6 o'clock, submitted in toto 13-18 Lesion from 7 and 8 o'clock, submitted in toto 19 Representative section from 3 o'clock fibrotic area 20 Section from the outer lower quadrant 21 Section from the inner upper quadrant 22 Section from the inner lower quadrant Page 3 ot 4
+
+--- Page 4 ---
+SURGICAL PATHOL Report E. Received fresh is a yellow, lobulated adipose tissue, measuring 3.0 x 2.0 x 2.0 cm. Four possible lymph ngdes identified, measuring from 0.4 up to 1.5 cm in the greatest dimension.  Sections submitted as follows:. 1&2 One lymph node per each cassette 3 Two lymph nodes, one is inked, also for frozen section. F. Received fresh is yellow, lobulated adipose tissue, measuring 2.0 x 2.0 x 0.5 cm. One tan soft lymph node is identified, measuring 0.4 x 0.4 x 0.4 cm. Submitted in toto in one cassette for frozen section.. G. Received fresh is a tan soft lymph node, measuring 0.7 x 0.6 x 0.6 cm. Bisected and submitted in toto in ohe cassette.. H. Received fresh is a tan soft lymph node, measuring 0.5 x 0.4 x 0.4 cm. Bisected and submitted in toto in ohe cassette. 1.  Received in molecular fixative is yellow, lobulated adipose tissue, measuring 2.0 x 2.0 x 1.5 cm.Three po$sible lymph.  nodes identified, measuring from 0.2 up to 0.4 cm in the greatest dimension. Sections submitted as follows: 1 Two lymph nodes 2 One lymph node J.  Received in molecular fixative is yellow, lobulated adipose tissue, measuring 14.0 x 6.0 x 2.5 cm. Twenty-one lymph. nodes are identified, measuring from 0.4 up to 3.0 cm in greatest dimension. Sections submitted as follows:. 1-4 Largest lymph node, submitted in toto. 5-15 One lymph node per each cassette 16&17  Five lymph nodes per each cassette iscrepancy DISQUALIFIED Page 4 of 4
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index 0000000000000000000000000000000000000000..3af13c423ec8d4ce5cdd15e06f066569b07e87a4
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+--- Page 1 ---
+Diagnosis: Right hemicolectomy preparation with tumor-free resection margins and including an. ulcerated, poorly differentiated mucinous adenocarcinoma of the ascending colon, with infiltration of the perimuscular fatty tissue and without evidence of local lymph node. metastasis (G3, pT3, L0 V0 R0 pN0 0/17).
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diff --git a/output/text/571bab3e-c0a7-4c01-9a5e-07b5d27ad3a1.txt b/output/text/571bab3e-c0a7-4c01-9a5e-07b5d27ad3a1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..cdfbec13792a2badc23dfa40fca7730dbeffc568
--- /dev/null
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+
+--- Page 1 ---
+UUID:40130FAC-455F-4987-A97E-CFFE02202925 TCGA-ED-A4XI-01A-PR Redacted Gross Description: Tumor is moderate-margins with 3x3x2cm in size, firm, solid, yellow-white , focal necrotic in cutting section. Microscopic Description: Tumor cells form the trabecular patterns, or tubular or acinar or sheets. patterns intervening in begnin tissue. The tumor cells retain apolygonal shape and have round vesicular. nuclei with prominent nucleoli. The amount of cytoplasm are abundant and the cytoplasm is eosinophilic or clear or vascuolated. Nuclei are very irregularly large and hyperchromatic with prominent. nucleioli. Mitoses are present. Tumor is necrotic and invasion of lymphocyte.. Diagnosis Details: Hepatocellular carcinoma, poorly-differentiated. Comments: Formatted Path Reports: LIVER TISSUE CHECKLIST Specimen type: Lobectomy icd-0-3 Caranonn, h@at cllule,Nos 817o13 Tumor size: 3 x 3 x 2 cm Site: 1Ner, N05 C02.0 Focality: Not specified w 1013/17 Histologic type: Hepatocellular carcinoma Histologic grade: Poorly differentiated Tumor extent: Not specified Lymph nodes: Not specified Venous invasion: Not specified Margins: Not specified Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None
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diff --git a/output/text/571dcf71-7bd6-432c-a7c7-3ebf1b82e910.txt b/output/text/571dcf71-7bd6-432c-a7c7-3ebf1b82e910.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8c88fe79d727839f31fb069eb190e7a5d10b81c3
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+
+--- Page 1 ---
+SUPPLEMENTAL REPORT COMMENT: Sections of the mandibular condyle which has been decalcified show icular surface of the condyle into the temporal mandibular joint. DIAGNOSIS CA) LEFT MAXILLECTOMY, MANDIBULECTOMY, BILATERAL. NECK DISSECTION, TOTAL LARYNGECTOMY,  PARTIAL" PHARYNGECTOMY AND INFRATEMPORAL RESECTION: INVASIVE SQUAMOUS CARCINOMA,I Moderately differentiated, 19.0 X 12.0 X 6.0 CM.(SEE COMMENT) (b) Teeth: Five molar teeth.. COMMENT Squamous carcinoma infiltrates the temporomandibular joint, mandibular ramus, palate, oropharynx, tongue, Taryngeal cartilage and soft tissue of the neck'bilaterally. The' mandibular condyle is to be processed following decalcification for which a supplemental report will~be issued. Tumor is not present in the representative margins examined. SPECIMEN (A) LEFT MAXILLECTOMY, MANDIBULECTOMY, BILATERAL NECK DISSECTION, TOTAL (b) Teeth: SNOMED CODES T-51004,M-80703 Page 1 of 1 History Case Pathology Report History Case Pathology File under: Pathology
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diff --git a/output/text/57333340-f817-47bd-aae6-48a343226536.txt b/output/text/57333340-f817-47bd-aae6-48a343226536.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e9855a416b55237f344ba6846e2763ad6124b0a6
--- /dev/null
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+
+--- Page 1 ---
+FINAL DIAGNOSIS: Part 1: kidney, right, radical nephrectomy - A. RENAL CELL CARCINOMA, UNCLASSIFIABLE (See Comment) B. FUHRMAn NUCLEAR GRADE iS 3-4. C. THere is eXTensive necrOsis. P. The GrEatest Diameter Of the neOplAsm IS 8.2 cm. E. The neoplasm exTends into the renal SinUs AdipOse TissuE. F.  NO iNVASION OF THE RENAL VEIn iS IDENTIFIED. G.  FOCI SUSPICIOUS FOR ANGIOLYMPHATIC INVASION ARE IDENTIFIED.  All SUrGiCAl MArGiNS ARe fREE Of The NeOpLASM. H. 1. THE NON-NEOPLASTIC KIDNEy iS UNREMARKABLE. TNM STAGE: pT3a N1 MX. 1 PARt 2: Lymph nODe, hIlAR, EXcisiON- A.  METASTATIC RENAL CELL CARCINOMA IN ONE (1) of ONE (1) LYMPH NODES WITH EXTRACAPSULAR EXTENSION. B.  The Lymph nODe mEAsuRES 3.8 Cm in GrREATest DimensiONs AND is COmpLeTeLy rEpLACEd BY METASTATIC CARCINOMA? Part 3: Adrenal gland, Adrenalectomy- UNREMARKABLE ADRENAL GLAND. A. B. NO EVIDENCE OF RENAL CELL CARCINOMA.
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diff --git a/output/text/57681068-0df1-4eb8-911b-5393cdb03c57.txt b/output/text/57681068-0df1-4eb8-911b-5393cdb03c57.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ff40319c42bf367692444d2f68d0ae8f378f5f73
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+--- Page 1 ---
+TCGA-DQ-5629 with history of right supraglottic T4N2cm0 squamous cell carcinoma. Total laryngectomy.. GROSS: 'Left level I lymph node' Received in formalin in a small container is a 0.4 cm bit. Frozen section control 2. 'Right tracheal esophageal groove' A 0.2 cm red bit. Frozen section control. 3. 'Right paratracheal node" A 0.2 cm, soft tissue fragment.. Frozen section control. 4. 'Right pyriform' A 1. x 0.4 cm red soft tissue fragment.. Frozen section control 5. .'Left pyriform' A 0.5 cm tan bit. Frozen section control. "Posterior cricoid* A 0.7 cm tan soft tissue fragment. Frozen section control. "Base of tongue' A 0.0 cm tan soft tissue fragment. Frozen section control. "Total laryngectomy wide field laryngectomy" Received in formalin in a medium container is an 8.3 x 5.9 x 5.1 cm laryngectomy with attached anterior strap muscles. The right pyriform mucosa is inked green and the left side is. inked blue. The previously opened larynx has an ulcerating 1.6 x 1 cm tumor which involves the right supraglottic mucosa, comes to within 1.5 cm of the right pyriform mucosal margin and 1.2 cm from the edematous right vocal cord. The ulcerating tumor also comes to within 4.8 cm of the tracheal margin. The cut surface into this ulcerating tumor shows diffuse submucosal penetration, enlarging the greatest dimension of this tumor to 2.7 cm. The maximum thickness is 1.8 cm, and it comes to within less than 0.1 cm of the thyroid cartilage and also within 0.1 cm of the hyoid bone. The gray-white, focally hyperemic tumor penetrates under the epiglottis and the anterior strap muscle The tumor does not appear to extend to the left vocal cord, commissure or pyriform sinus. The right true vocal fold has an ill-defined, black area that appears to be 0.7 cm in greatest dimensions. No other mass nor lesion is readily seen. 8A. Right mucosal margin. 8B. Left mucosal margin. 8c. Tracheal margin. 8D-G. Sections of tumor to py riform sinus, vocal cord, thyroid cartilage and hyoid bone respectively. (F and G after decal) 8H. Section of tumor involving epiglottis and anterior strap muscle. 81. Unremarkable left pyriform sinus. 8J. Left vocal cord. 9. "Left selective neck level II' Received in formalin in a small container is a 5.1 x 3.3 x 1.6 cm irregular ovoid portion of focally nodular fatty tissue. within the fat are lymph node candidates up to 2.1 cm in greatest dimensions. The cut surface of the two largest cysts are pink-tan and focally. hyperemic. 9A. Four whole lymph node candidates. 9B. One bisected lymph node candidate 9c. One bisected lymph node candidate. 10. "Left selective neck level III"  Received in formalin in a small container
+
+--- Page 2 ---
+is a 4.7 x 2.7 x 1.4 cm irregular ovoid portion of focally nodular skeletal muscle and fatty tissue. Small lymph node candidates are retrieved from the irregularly shaped portion, and no evidence of mass nor lesion is readily seen in the skeletal or fatty tissue. 10A. Five whole lymph node candidates. 10B. Skeletal muscle. 11. "Left selective neck level Iy  Received in formalin in a small container is a 4.1 x 2,8 x 1.4 cm irregular ovoid portion of fatty and soft tissue. A metal staple is attached without designation, and no evidence of lymph node candidates are readily seen nor palpated in the portion. 11A-C. Level IV tissue.. 12. "Right selective neck level II' Received in formalin in a small container is a 6 x 3.2 x 1.3 cm irregular ovoid portion of fatty tissue. Multiple staples are attached without designation. Multiple Iymph node candidates within the fatty tissue are retrieved up to 1.3 cm in greatest dimensions. 12A. Five whole lymph node candidates. 12B. Three whole lymph node candidates. 13. *Right selective neck level Iir".  Received in formalin in a smal1. container is a 7.3 x 3.6 x 1.2 cm irregular ovoid portion of fibromembranous tissue that is focally nodular. Multiple staples are attached without designation, and the nodular portions between the fibromembranous tissue appear consistent with skeletal muscle that is unremarkable. No evidence of 1ymph node candidates are readily seen. 13A-D. Right leve1 III. [14. *Right selective neck level Ivs Received in formalin in a small container Jis a 4.7 x 3.1 x 1.3 cm focally nodular portion of fatty tissue. within the fatty tissue are multiple lymph node candidates up to 1.9 cm in greatest dimensions. 14A. Ten whole lymph node candidates. 14B. Three whole lymph node candidates. 15. "Right paratracheal nodes and pretracheal nodes". Received in formalin in. a small container are two irregular ovoid portions of fatty and soft tissue. The smaller is 4.1 x 2.7 x 1.4 cm and the larger is 4.7 x 2.3 x 1.2 cm. within the cut surface of the smaller portion is a 3.6 x 2.2 x 0.9 cm portion of red-brown soft tissue that appears consistent with thyroid. No lymph node candidates are readily seen or palpable in the portion, as the remainder of the tissue is unremarkable skeletal muscle. The larger portion has multiple Iymph node candidates up to 0.7 cm in greatest dimension. 15A. Skeletal muscle from smaller portion. 153. Possible.thyroid tissue from smaller portion. 15c. Nine lymph node candidates from larger portion. fat retained and soft  tissue retained). FROZEN SECTION REPORT 1. One lymph node negative for malignancy 2. One lymph node negative for malignancy. 3-7. Negative for malignancy!.  have reviewed and interpreted the frozen section. material at the time it was requested. have reviewed and interpreted the frozen sectior naterial at the time it was requested.. Permanent sections confirm frozen section reports.. MICROSCOPIC: SQUAMOUS LESIONS OF HEAD & NECK:  RESECTION
+
+--- Page 3 ---
+Site: Supraglottic larynx. Findings: Squamous carcinoma. Differentiation: Moderate. Subtype: N.A. Ulcerating Gross: Size 2.7 cm (1argest dimension).. Invasion: Present If present: depth 1.2 cm. Tumor border: Infiltrative. Perineural invasion: Present. Vascular invasion: Absent. Bone/Cartilage invasion: Absent. Lymphocyte infiltration: Absent. Margins: Negative. SQUAMOUS LESIONS OF HEAD & NECK: LYMPH NODE DISSECTIONS RIGHT LEVEL Extracapsular (or site) #Positive #Negative extension I1 1 7 No IIE 0 0 N.A. IV 1. 12 No Paratracheal and pretracheal 0 11 N.A. TOTAL 2 30 LEFT LEVEL Extracapsular (or site) #Positive #Negative extension 0 1 N.A.
+
+--- Page 4 ---
+N.A. III 5 N.A. IV N.A. TOTAL 15 MICROSCOPIC DIAGNOSIS: 1. Left level I lymph node, resection: One lymph node, negative for. malignancy. 2. Right tracheal esophageal groove, resection: One lymph node, negative for. malignancy. 3. Right paratracheal lymph node, resection: One lymph node, negative for malignancy. 4-5. Right and left pyriform, resection: Negative for malignancy.. 6. Posterior cricoid, resection: Negative for nalignancy. 7. Base of tongue, resection: Negative for malignancy. 8. Larynx, total laryngectomy: Invasive, moderately-differentiated squamous cell carcinoma (2.7 cm diameter; 1.2 cm depth) arising in right supraglottis and involving paraglottic and pre-epiglottic spaces. No cartilage invasion or 1eft vocal chord involvement. Perineural invasion identified. Margins free. See template. 9. Left neck, level II lymph nodes, resection: Six lymph nodes, negative for malignancy. 10. Left neck, level Iir lymph nodes, resection: Five lymph nodes, negative for malignancy: 11. Left neck, level Iv lymph nodes, resection: Three lymph nodes, negative for malignancy. 12. Right neck, level II lymph nodes, resection: Metastatic squamous cell. carcinoma involving one of eight lymph nodes. No extranodal extension. identified. 13. Right neck, level IIi lymph nodes, resection: Skeletal muscle and fibroadipose tissue, negative for malignancy. No lymphoid tissue identified.. Entire tissue submitted for evaluation. 14. Right neck, level Iv lymph nodes, resection: Metastatic squamous cell carcinoma involving one of thirteen lymph nodes. No extranodal extension identified. 15. Right paratracheal and pretracheal lymph nodes, resection: Nine lymph nodes, negative for malignancy. Unremarkable thyroid tissue.
+
+--- Page 5 ---
+the signing staff pathologist, have personally xamined and interpreted the slides from this case. Code:r #Olose
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index 0000000000000000000000000000000000000000..606ae2165a89b6f46ec69ce40ceab0c1cefc9677
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+SURGICAL PATHOLOGY MEDICAL RECORD SURGICAL PATHOLOGY PATHOLOGY REPORT Laboratory: Accession No. Submitted by: Date obtained: LD  3 Specimen (Received A. BASE OF RIGHT RENAL TUMOR F.S. Sct.: 1 (R) Hney NOS Cb4.9 B. RIGHT RENAL TUMOR  wzrl3 BRIEF CLINICAL HISTORY: UUID:41687B96-A8A7-46D1-B7A4-6181BB2BEE27 TCGA-MH-A856-01A-PR Redacted PREOPERATIVE DIAGNOSIS: right renal mass OPERATIVE FINDINGS: POSTOPERATIVE DIAGNOSIS: right renal mass Surgeon/physician: PATHOLOGY REPORT Laboratory: Accession No. GROSS DESCRIPTION: A. The specimen is received fresh and consists of a 0.3 x 0.2 x 0.1 cm, tan-red, irregular soft tissue fragment submitted fresh for. intraoperative frozen section consultation. The specimen is submitted. in toto for frozen and permanent sections in cassette FsA. FROZEN SECTION DIAGNOSIS: FsA. Kidney, right base of tumor, biopsy: - NO TUMOR SEEN B. The specimen consists of a 26.0 g, 4.8 x 3.8 x 3.5 cm, tan-brown, irregular soft tissue displaying a tan-brown, granular renal resection margin. The capsular margin is tan-pink to red and smooth with minimal attached overlying fat. The renal resection margin is inked. blue, and the capsular margin is inked black. The specimen is serially sectioned to reveal a 2.4 x 2.3 x 1.8 cm, tan-yellow to white, friable, well-demarcated mass that grossly is less than 1 mm from both the capsular margin, as well as the renal resection margin. There are minimal amounts of adjacent uninvolved renal parenchyma. The specimen is submitted in its entirety sequentially in cassettes B1-B12.
+
+--- Page 2 ---
+Please note, a representative portion is taken for tissue bank. MICROSCOPIC EXAM FINAL DIAGNOSIS: A. BASE OF RIGHT RENAL TUMOR, EXCISIONAL BIOPSY: - RENAL TUBULAR AND SOFT TISSUE, NO TUMOR SEEN. B. RIGHT RENAL TUMOR, EN BLOC RESECTION: PROCEDURE : PARTIAL NEPHRECTOMY. LATERALITY: RIGHT. TUMOR SITE: NOT PROVIDED. TUMOR SIZE: 2.4 CM. TUMOR FOCALITY: ONE FOCUS. MACROSCOPIC EXTENT OF TUMOR: CANNOT ASSESS. HISTOLOGIC TYPE: PAPILLARY CELL CARCINOMA, TYPE I. TUMOR NECROSIS: FOCAL AT 2 % HISTOLOGIC GRADE: GRADE 1-2. MICROSCOPIC TUMOR EXTENSION: INTO PELVIS AND CAPSULE REGION.S SURGICAL MARGINS: MANY AREAS INVOLVED WITH TUMOR. GEROTA'S FASCIAL MARGIN: CANNOT BE ASSESSED. LYMPH-VASCULAR INVASION: NOT IDENTIFIED. PATHOLOGICAL STAGE (pTNM) APPEARS TO BE pTla. NONNEOPLASTIC KIDNEY: - MILD ARTERIO- AND ARTERIOLOSCLEROSIS. COMMENT : CONCURS WITH NEW MALIGNANCY. IMAGES ARE AVAILABLE IN NOTIFIED VIA ON
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diff --git a/output/text/578b110f-807e-409e-9897-b2e8f87f9344.txt b/output/text/578b110f-807e-409e-9897-b2e8f87f9344.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9d614f0ad2b362a19fc24570a5e219bcc89e0044
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+
+--- Page 1 ---
+1 eferring Physician: UUID: 3877A3E1-AB8F-47B2-A5CC-A38593A055CEE TCGA-AC-A3W7-01A-PR Redacted Dob: Age. Gender: Ref#: Hosp#: Provider Group : Date of Service: Date Received: Outpatient Case #:  Room: Date Reported: A copy of this report will be faxed to:. FINAL SURGICAL PATHOLOgy REPOrt Diagnosis: A. - b.) breast, AxIllAry Lymph node, right, mastectomy And SENTINEL LyMPH NODE bIOPSy (400): - Invasive lobular carcinoma, grade 1.. - Multifocal, 40 mm, 14 mm and 5 mm in greatest dimension. - Lobular carcinoma in situ (LCIS). - Surgical margins negative.. - One of two lymph nodes, POslTIVE metastatic carcinoma (1/2) - Largest focus in Iymph node: 2.5 mm icD-o-3 - No extracapsular extension identified. Carcinora,lobuar, inFi ItaHng 8 5aOJ Sit: bregst,no s C. breast, left, mastectomy:  - Sclerosing adenosis, usual ductal hyperplasia, columnar cell change and. Cs0.9 apocrine metaplasia.. S1-sZ - No atypical hyperplasia or carcinoma identified.. rD PATHOLOGIC TUMOR STAGING SYNOPSIS (RIGHT BREAST): Type and grade (invasive): Invasive lobular carcinoma, grade 1.. Type and grade (in situ): Lobular carcinoma in situ (LCIS). Primary tumor: pT2. Regional lymph nodes: pN1a (1 of 2 lymph nodes POsiTIVE). Distant metastasis: N/A. Pathologic stage: IIB. Lymphovascular invasion: Not identified. Margin status: R0, negative, all margins 20 mm or greater.. Breast Invasive Tumor Stag' 7 Information (AJCC Cancer Staging Handbook. Ed, and Drotocol, This staging also incorporates: Previous biopsy: Breast profile: Case #: Page 1 Printed: This report continues... (FINAL). Phone: MR No. - tcct No. - Patient Name - Pathology Report - Page 1/5 Page 1
+
+--- Page 2 ---
+Case #: Specimen type: Total breast. Specimen procedure: Total mastectomy. Lymph node sampling: Sentinel lymph nodes. Specimen integrity: Single intact specimen. Specimen laterality: Right. Specimen size (other than mastectomy): N/A. INVASIVE TUMOR FEATURES: Invasive tumor size: 40 mm, 14 mm, 5 mm. Invasive tumor site: 10:30. Invasive tumor focality: Multiple foci. Histologic type: Invasive lobular carcinoma. Total Nottingham Grade: Grade 1, cumulative score 5 of 9. Tubule formation: Less than 10%, 3 of 3. Nuclear Pleomorphism: Low-grade, 1 of 3. Mitotic count for Nottingham: Low, 1 of 3. Mitotic count: 2 per 10 high power field. Other Grading System: N/A. Lymphatic invasion: Not identified. MARGIN STATUS FOR INVASIVE COMPONENT RO, negative. Distance of tumor from margins: Closest margin: All margins 20 mm or greater. Other margins: N/A. DUCTAL CARCINOMA IN-SITU (DCIS): Not identified.  LOBULAR CARCINOMA IN-SITU (LCIS): Present. Skin: Present, not involved. Nippie: Present, not involved. Skeletal Muscle: Not identified. LyMPH NODES: 1 of 2 lymph nodes positive, 2.5 mm focus, no. extracapsular extension identified. INVASIVE PATHOLOGIC TUMOR STAGING (pTNM) Primary tumor (pT): pT2. Regional lymph nodes (pN) pN1a (1 of 2 lymph nodes positive) Distant metastasis (pM): N/A. Pathologic stage: 118. RECEPTOR STATUS AND HER2/NEU: Estrogen receptors: POSITIVE (99-100% positive cells. strong intensity). Progesterone receptors: Negative (0% positive cells). Her2/neu: Negative (0, scale 0-3+). Ki-67 proliferative index: Intermediate (11% positive cells) Case # Page 2 1 Printed: This report continues... (FINAL) Phone: MR No. Acct No. - Patient Name - 3 Pathology Report - Page 2/5
+
+--- Page 3 ---
+Case #: FINAL SURGICAL PATHOLOGY REPORT Comment: The touch preparation of the sentinel lymph node biopsy was review and no evidence of metastatic carcinoma is identified. Additional pathologic findings: Usual ductal hyperplasia, columnar cell change and apocrine metaplasia. Signed by Source of Specimen: A. Sentinel lymph node;right sentinel node axillary B. Breast,right breast. C. Breast:left breast. Clinical History/Operative Dx: Right/left breast cancer. Intraoperative Diagnosis: A. Right sentinel node axillary 1: No tumor cells identified. (Dr. I. The intraoperative. interpretation(s) was/were performed and rendered at Gross Description: A. The specimen is labeled right sentinel node axillary and is received without fixative. It consists of two lymph nodes measuring 1 x 0.7 x 0.7 cm and 1.5 x u.s x 0.4 cm. Both nodes are serially sectioned and touch imprints are obtained. The larger node is submitted for permanent section in cassettes A1-A2. The smaller node is submitted for permanent section in cassette A3. Case #: Page 3 Printed: Tnis report continues... (FINAL) Phone: MR No. - Acct No. - Patient Name - 3 Pathology Report - Page 3/5 Page 3
+
+--- Page 4 ---
+Case #: FINAL SURGICAL PATHOLOGY REPORT B. The specimen is labeled right breast tissue and is received without fixative. It consists of a mastectomy specimen which weighs 381 grams. A black suture at one end of the skin ellipse marks medial. With this orientation, the specimen measures 16 cm from medial to lateral, 11 cm from superior to inferior, and 4 cm from anterior to posterior. There is an overlying ellipse of tan skin measuring 11.8 x 7 cm. The areola measures 3.3 cm and the nipple appears slightly inverted. The anterior-superior margin is inked blue, the anterior-inferior margin is inked green, and the posterior margin, which consists variably of smooth facial appearing tissue and lobulated fatty tissue, is inked black. The breast is serially sectioned along the superior-inferior axis resulting in fifteen slabs. Slab #1 is most medial.. In the central portion of the excision, in slabs 6-9, there is a stellate hard, gritty neoplasm (tumor #1) which overall measures 4 cm from medial to lateral, 1.2 cm from superior to inferior, and 1 cm from anterior to posterior. This neoplasm is 1.5 cm from the closest skin. It is 2 cm from the closest anterior-superior margin and is greater than 4 cm from all other margins. Representative sections of the medial portion of the tissue are obtained for research purposes and the biopsy site clip is identified within the neoplasm in siab 7. Slab 10 (intervening tissue between tumor #1 and tumors #2 and #3) consists of palpably unremarkable fibrofatty tissue In slab 11, 1 cm lateral to the tumor #1, there is chalky yellow discoloration and slight retraction of the ribrofatty tissue suggestive of two small deposits of neoplastic tissue. The larger of these (tumor #2) is 8 cm Iateral to the nipple. It measures 1.4 x 1 x 0.6 cm and is greater than 2 cm from the anterior-superior. anterior-inferior, and posterior margins. It is 2.3 cm from the closest lateral mmargin and widely free of the medial margin. The smaller tumor deposit (tumor #3) measures 0.5 cm and is 0.8 cm superior of the larger deposit in slab 11. It is 2 cm from the closest anterior-superior margin and greater than 2 cm from all other margins. No other palpable lesions are identified. No lymph nodes are identified within the lateral portion of the excision. Representative sections are submitted. Section summary: B1) nipple and tissue just deep to nipple B2) medial edge of tumor #1 from slab 6, 83) anterior-superior margin (tumor #1), slab 6. B4) central sections of tumor #1 from slab 7 (biopsy site clip here),. B5) anterior-inferior margin (tumor #1) from slab 7, 36) tumor #1 from slab 8 including closest anterior-superior margin,. 87) lateral section of tumor #1 from slab 8, B8) representative section from slab 10 intervening tissue between tumor #1 and tumors #2 and #3, 89) complete cross-section, slab 11, tumor #2 and #3, B10) section of tumor #2 in slab 12, B11) representative upper inner quadrant (slabs 2, 3, 4),. B12) representative lower inner quadrant (slabs 3, 4, 5), B13) representative lower outer quadrant (slabs 9 and 10). C. The specimen is labeled left breast tissue and is received in formalin. It consists of a mastectomy specimen weighing 341 grams. A black suture at one end of the skin ellipse marks medial. With this Page 4 Case #. Printed: This report continues... (FINAL). Phone: Mr No. : Acct No. Patient Name Pathology Report - Page 4/5. 4J - rage 4
+
+--- Page 5 ---
+Patiant. Case #: FINAL SURGICAL PATHOLOGY REPORT orientation, the specimen measures 15.5 cm fron medial to lateral, 11 cm from superior to inferior, and 5.5 cm from superficial to deep. There is an overlying broad ellipse of tan skin which measures 12 x 7 cm. In the lateral skin, there is a 0.4 cm violaceous skin lesion. Centrally, there is a well-delineated 4 cm areola and a flat to slightly retracted appearing 1 cm nipple. The anterior-superior margin is inked blue, the anterior-inferior margin is inked green, and the posterior margin, which consists of lobulated fatty tissue, with central fascial appearing tissue, is inked black. The specimen is serially sectioned at close intervals to reveal lobulated fatty tissue and scattered tan-white fibrous parenchyma which is most prominent centrally. The fibrous parenchyma is focally finely nodular to palpation but there are no discrete areas suggestive of invasive neoplasm. There are scattered small fluid-filled cysts within the fibrous parenchyma. No lymph nodes are identified within the lateral portion of the excision. Representative sections are submitted. Section summary: C1) nipple and tissue just deep to nipple, C2) lateral skin lesion. C3) representative upper inner quadrant,. C4) representative lower inner quadrant,. C5) representative upper outer quadrant,. C6) representative lower outer quadrant, C7-C8) sections of central breast including central deep margin Microscopic Description:. A. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered. Immunohistochemistry was performed with adequate control and shows positive staining for metastatic tumor cells in one lymph node.. B. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered. C. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered Dr. totified of results on. at Case #: Page 5 Printed: END OF REPORT (FINAL) Phone: MR No. Acct No. . Patient Name - 1 Pathology Report - Paye 55 Page 5
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diff --git a/output/text/57b30b3f-6567-4783-9d50-c8a507f9a1e7.txt b/output/text/57b30b3f-6567-4783-9d50-c8a507f9a1e7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8639e36eb175a6cfe6a1ee30a56a9969e958a5f6
--- /dev/null
+++ b/output/text/57b30b3f-6567-4783-9d50-c8a507f9a1e7.txt
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+
+--- Page 1 ---
+UUID: 05EFF049-BF35-4D89-8968-5442C5FF375A Redacted TCGA-FA-A4XK-01A-PR Gross Description: Tumor is located in Jejunum. It is protruded and ulcerated, occupying circumference with 10x8x3cm in size, soft, white and gray surface. Microscopic Description: Tumor cells arrange in diffuse, replace glands or intervening in begnin glands. The tumor cells are composed of large transformed lymphoid cells and multinuclei giant cells, with hyperchromatic nuclei. Tumor cells are oval or round in shape with scant cytoplasm. Nucleoli is single or multiple. Mitotic figures are commnon. Diagnosis Details: Malignant lymphoma, Large B cell, diffuse type. IHC testing was performed; tumor cells are positive for CD20. Tumor cells are negative for CD3 and CKAE1/AE3. 1ed-c-3 Comments: Lymphoma, Large B-cell Formatted Path Reports: LYMPHOMA Diffuse NtS 968c/3 Tumor location: Small intestine, jejunum Ste: Sras) ntestine, jejunum Tumor size: 10 x 8 x 3 cm Ci7 o/13 Tumor features: Ulcerated, diffuse Specimen type: Diffuse large b-cell lymphoma of the small intestine Tumor invasion: Unspecified Lymph nodes: 0/3, mesenteric Diagnosis Details: Malignant lymphoma, Large B cell, diffuse type. Comments: IHC testing results: CD20- positive, CD3- negative, CKAE1/AE3- negative
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diff --git a/output/text/57e226f8-23ab-4142-bf58-8de68ca4985e.txt b/output/text/57e226f8-23ab-4142-bf58-8de68ca4985e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..72390e5d2d56460ee48737801de7d46bf49a4012
--- /dev/null
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+
+--- Page 1 ---
+Icd-0-3 Carcinoma,1Obwleu,mfil+ratwg 85aof3 C 50.9 S.te code:breast, NoS 12|3f10 lw Final diagnosis Breast,right, simple mastectomy: Invasive mammary carcinoma, Nottingham grade II (of III), with predominantly lobular features is identified forming multiple (4) masses (ranging in size from 0.7 cm to 1.6 cm in greatest dimension) (AJCC pTc) situated in multiple quadrants (lower inner quadrant, inferior central, upper outer quadrant, and 12 o' clock position). There is a minimal (5%) component of ductal carcinoma in situ, intermediate nuclear grade. No angiolymphatic invasion identified. Tumor closely approaches (0.1 cm) the original inferior margin. Skin, nipple, and final surgical margins (after re-excision) are negative for tumor. Lymph nodes, right axillary sentinel, excision: Multiple (5) right axillary sentinel lymph nodes are negative for tumor (AJCCpN0(sn)(i-)). Blue dye is identified in all five right axillary sentinel lymph nodes. Immunohistochemical cytokeratin stain was performed on the paraffin embedded sentinel lymph node tissue and confirms the H&E impression. HER2/neu protein overexpression is negative, score of 1+, according to the interpretation guidelines in the FDA-approved HercepTest. UUID:F4DBFC71-9CD0-41C3-9F20-77FA0605D4A8 Redacted
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diff --git a/output/text/5815bb0b-3b91-4317-904f-a94011b7ce03.txt b/output/text/5815bb0b-3b91-4317-904f-a94011b7ce03.txt
new file mode 100644
index 0000000000000000000000000000000000000000..071c1bc5d41fca8cd9f1fa3b4e2857b74bca7e9b
--- /dev/null
+++ b/output/text/5815bb0b-3b91-4317-904f-a94011b7ce03.txt
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+
+--- Page 1 ---
+/cs-0- 3 Caranomn, 1obulw, Nos 8sao/3 Patient: S.h Cod: brst, Nos L50.9 1/i7fn h Surgical Pathology: Fina Surg Path CLINICAL HISTORY: Inflammatory breast ca. Breast cancer. GROSS EXAMINATION: A. "Left breast biopsy," received fresh. A fragment of skin which is 3.3 cm long and 0.4 cm in diameter attached to underlying fibroadipose tissue which is 2.7 cm thick x 3.5 x 1 cm in greatest dimensions. The specimen has been previously partially sectioned revealing a poorly defined area of pink tissue. measuring approximately 2.5 x 1.5 x 1 cm in greatest dimensions. This does not represent the true sides of the lesion..  Portions of the tissue have submitted for ER/pR evaluation. It is noted that this is a representative fragment of.  larger lesion and margins are not require for the specimen. Representative sections are submitted in Blocks Al and A2. DIAGNOSIS: A. BREAST, LEFT, INCISIONAL BIOPSY: POORLY DIFFERENTIATED CARCINOMA WITH EXTENSIVE VASCULAR INVASION. IN SITU CARCINOMA IS NOT PRESENT. NOTE: THE TUMOR HAS FEATURES OF LOBULAR CARCINOMA, BUT AN IN SITU COMPONENT IS NOT PRESENT. Verified by: UUID:DFCA9C6E-710E-4645-9CFC-A908AAD583F3 TCGA-B6-A0IE-01A-PR Redacted eBrowser Result for: 1 of 1
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diff --git a/output/text/58a0b6b9-5c83-42e8-906b-63c44705226f.txt b/output/text/58a0b6b9-5c83-42e8-906b-63c44705226f.txt
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index 0000000000000000000000000000000000000000..2a5c334f40484d3025f0c1495517e88dd19e84b7
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+
+--- Page 1 ---
+UUID:5914C86E-637F-496A-B416-E9E750527042 TCGA-MH-A55Z-01A-PR Redacted SURGICAL PATHOLOGY SURGICAL PATHOLOGY PATHOLOGY REPORT RIGHT RENAL MASS 1cs-0-3 BRIEF CLINICAL HISTORY: Cnrcinong,pepillay_^ral ell_83bof3 PREOPERATIVE DIAGNOSIS:S right renal mass Sig: Kiny ncs Cb4.9 OPERATIVE FINDINGS: POSTOPERATIVE DIAGNOSIS: right renal mass PATHOLOGY REPORT GROSS DESCRIPTION: Received fresh is a 112.3 g, 5.8 x 5.3 x 4.7 cm partial nephrectomy specime displaying moderate amounts of attached peinephric fat. The. renal resection margin is tan-red and scabrous..  The capsular margin is tan-white and smooth. and the capsular margin is inked black.  The specimen is serially. sectioned to reveal a 5.2 x 3.9 x 3.5 cm, tan-yellow to red, to orange, variegated, well mscribed mass that is 0.3 cm from the renal resection margin, and less than 0.1 cm from the capsular resection margin. Grossly the mass is confined to the renal capsule. The rim of uninvolved renal parenchyma is tan-brown and unremarkable.. Sectioning through the attached fat does not reveal any obvious lymph nodes. No adrenal gland is identified. Representative sections are submitted as follows: 1-5- mass to renal resection margin; 6-8- mass to capsule resection margin.. MICROSCOPIC EXAM FINAL DIAGNOSIS: RIGHT RENAL MASS, RESECTION:S PROCEDURE: PARTIAL SPARING NEPHRECTOMY. LATERALITY: RIGHT. TUMOR SITE: NOT PROVIDED. TUMOR SIZE: 5.2 CM TUMOR FOCALITY: SINGLE LESION. MACROSCOPIC EXTENT OF TUMOR: CONFINED TO PARENCHYMA HISTOLOGIC TYPE: PAPILLARY RENAL CELL CARCINOMA. TUMOR NECROSIS: NOT IDENTIFIED. HISTOLOGIC GRADE: G2. MICROSCOPIC TUMOR EXTENSION: CONFINED TO KIDNEY. SURGICAL MARGINS GEROTA'S FASCIAL MARGIN: FREE OF TUMOR. RENAL PARENCHYMAL RESECTION MARGIN: FREE OF TUMOR. PATHOLOGICAL STAGE (pTNM) : pTlb.
+
+--- Page 2 ---
+NONNEOPLASTIC KIDNEY: FOCAL GLOMERULSCLEROSIS. ARTERIO- AND ARTERIOLONEPHROSCLEROSIS. - INTERSTITIAL FIBROSIS AND CHRONIC INFLAMMATION SEEN. CONCURS WITH NEW MALIGNANY.  IMAGES ARE COMMENT : AVAILABLE IN UROLOGY NOTIFIED MD (End of report. J 1if2s[1>
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diff --git a/output/text/58b5fc7f-2921-40ff-a075-74ac72000288.txt b/output/text/58b5fc7f-2921-40ff-a075-74ac72000288.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5d31fb7aa1a56ff4d755534a91800d5e7df2ece2
--- /dev/null
+++ b/output/text/58b5fc7f-2921-40ff-a075-74ac72000288.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Procurement Date Laterality:Left Path RepOrt:BREAST TISSUE CHECKLIST Specimen type: Mastectomy Specimen size: Not specified Tumor site: Breast Tumor size: 2 x 2.5 x 2 cm Grossly evident lesion: Yes Histologic type: Medullary carcinoma Histologic grade: Moderately differentiated Tumor extent: Not specified Lymph nodes: Not specified Extracapsular invasion of the lymph nodes: Not specified Margins: Not specified UUID:1F02AA5F-67B1-4BAF-A3A9-CA20BCD7FBAF Nottingham Histologic Score TCGA-E9-A3QA-01A-PR Redacted Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified i iD-O-3 carcinona,medulary, NOS Mitotic count (40x): Not specified 8s10|3 Total Nottingham Score: Score cannot be determined. Site: Breas+,Nos c 50.9 Evidence of neo-adjuvant treatment: Not specified. Z Z8 1Z ro Additional pathologic findings: Not specified Comments: None
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diff --git a/output/text/58bc6571-0be2-4f35-9a4d-fa7da9575e0b.txt b/output/text/58bc6571-0be2-4f35-9a4d-fa7da9575e0b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b25bce74b476d4a501ea94458951a1bfb9e236ce
--- /dev/null
+++ b/output/text/58bc6571-0be2-4f35-9a4d-fa7da9575e0b.txt
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+
+--- Page 1 ---
+Diagnosis: This is a mucinous adenocarcinoma in I) with infiltration of the muscularis and vessels (G3, pT2 L1, V1) with free resection margins and free lymph nodes (locally R0, pN0, 0 of 12).. in II) a free anastomosis ring and in IIl) fragments of a serrated adenoma with focally severe chromatin disorders in the sense of a high-risk type of
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diff --git a/output/text/58c05fc2-2aa8-4fa7-91e0-4f60fdae1cfd.txt b/output/text/58c05fc2-2aa8-4fa7-91e0-4f60fdae1cfd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e106c372584be68f2d3cad28dc29b6efeb592072
--- /dev/null
+++ b/output/text/58c05fc2-2aa8-4fa7-91e0-4f60fdae1cfd.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID: 5E14E7CA-3417-4379-8EE3-7F00D6D4A02B TCGA-A7-A4SC-01A-PR Redacted Final Surgical Pathology Report Procedure: Diagnosis A. Right axillary sentinel node, excisional biopsy:. Single lymph node negative for metastatic tumor (0/1) B. Breast, right, simple mastectomy:. Invasive lobular carcinoma, grade 1 Tumor size 7.5 cM (pT3) Resection margin negative for tumor 1es-0-3 Microscopic Description: A. and B. Microscopic examination performed. carcinoma nifittratny Jobulu NOS Invasive carcinoma: Histologic type: Invasive lobular carcinoma 85 3s/3 Histologic grade: 1. S: bruot Nos c50.9 Overall grade: Architectural score: 3 Nuclear score: 1 Mitotic score: 1 Greatest dimension (pT) 7.5 cM (pT3) Specimen margins: Negative for malignancy, deep margin is l.4 cm from tumor Vessel invasion: Not identified Calcification: Focally present Nipple (Paget's ): Unremarkable, no Paget's disease identified Invasion of skin or chest wall: Not identified Ductal carcinoma in situ: No ductal carcinoma in situ identified. Description of non-tumorous breast: Fatty and atrophic. Adjacent to the tumor are too small 1 cm fibroadenomas which are invaded by the tumor. Lymph nodes: Number of positive nodes of total: 0/1 Extracapsular extension (present/absent): No extracapsular tumor identified pN:  snpNO 2 H&E-stained sections were evaluated from each frozen section block. An additional 3 H&E stained sections from each tissue block were evaluated of the formalin fixed paraffin embedded tissue. Also pancytokeratin AE1/AE3 immunohistochemical stains were evaluated from each of the tissue blocks. No metastatic tumor was identified in any of these examined sections. [A few of the antibodies used in our laboratory may be classified as analyte specific reagents. These antibodies are monitored and controlled in our laboratory and their performance for in vitro diagnosis is well described in the medical literature.. been cleared or approved by the FDA.]  They have not Distant metastasis (pM): Not applicable pMX was repeated given the limited amount of tumor in the prior core biopsy.
+
+--- Page 2 ---
+Results Progesterone receptor: 0%. Her2 by IHC: 2+ Interpretation Estroqen receptor: Reported as positive on prior core biopsy Progesterone receptor: Negative Her2 by IHc: Equivocal by IHC. FIsh testing ordered Comments Fixation time: 28 hours Less than Cold ischemia time: Time of collection was not noted.  Favor less than 1 15 minutes cold ischemia time in the laboratory. hour of transport time. 'CAP guidelines The analyzed tissue met quality requirements of the for Her2 testing.  Control materials stained appropriately. Based on data collected in our laboratory and reported in the literature we recommend FIsh analysis for Her2 in cases that stain with intermediate intensity by immunohistochemistry.. Prognostic markers were done by immunohistochemical stain on paraffin sections from 10% neutral buffered formalin fixed tissue using Ventana corportation antibodies on a Benchmark automated stainer.. The Her2 antibody is clone 4B5 and has been approved by the FDA as an aid in the assessment of breast cancer patients for whom Herceptin treatment is considered. This laboratory meets the test validation and quality assurance /CAP guidelines for Her2, ER and PR testing for requirements of the carcinoma of the breast Specimen A.  Right axillary sentinel lymph node, excisional biopsy:. B. Right breast, simple mastectomy Clinical Information year-old white female with infiltrating lobular carcinoma Intraoperative Consultation. A. Right axillary sentinel node, biopsy: No tumor seen.. Gross Description Received fresh for frozen section labeled "right axillary sentinel The fat is node" is a 3 x 1 x 1 CM piece of fatty yellow tissue. trimmed to reveal a 2.8 cm diameter tan lymph node. The lymph node is bisected and entirely frozen as frozen sections AFs 1 AFs 2.' The fat is retained..  No blue staining was identified and no grossly suspicious. areas are identified.. B. Received fresh and subsequently fixed in formalin labeled "right breast" is a 20.5 x 17.2 x 4.7 cm yellow lobular fatty tissue fragment is grossly consistent with a mastectomy and is partially covered with a 7.5 x 3.5 cm pink-tan wrinkled skin ellipse having a 1.4 cm everted nipple. The specimen has a suture designating superior breast. The and fixed in formalin at. specimen is received in pathology at The deep aspect of the specimen is inked lumen and the. specimen is sectioned from medial to lateral to show a 7.5 x 6.0 x 2.3
+
+--- Page 3 ---
+cm white-tan, diffusely nodular and firm central mass is ill circumscribed and comes within 1.7 cm of the deep margin. Gross identified centrally are white rice-like pellets which are grossly consistent with a previous biopsy site. The remainder of the cut surface of the specimen is predominantly fatty scanty fibrous tissue specimen. Representative sections of the specimen are submitted as follows: 1 - entire nipple with representative skin, 2 - 6 - representative sections of lesion including tumor to deep margin and representative lower outer quadrant, 9 - representative lower inner quadrant, 10 - representative upper inner quadrant.
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diff --git a/output/text/58dccd29-0031-4b2d-b4f6-6d2de1ba7988.txt b/output/text/58dccd29-0031-4b2d-b4f6-6d2de1ba7988.txt
new file mode 100644
index 0000000000000000000000000000000000000000..928a22204f6a278c72016f3d1924977a269754a9
--- /dev/null
+++ b/output/text/58dccd29-0031-4b2d-b4f6-6d2de1ba7988.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:15AE69C3-52C2-4CD3-A1BD-6E4EAD5B6631 Redacted TCGA-MQ-A4L1-01A-PR Result Type: Renort Result Date: Result Status: Result Title: Performed by: 1cs-0-3 Muosthehioma, lpithelioid, Nas 9053/3 * Final Report * 3itv: plevrr,Nos c38.4 SPECIMEN DESCRIPTION 10/4/13 (NOTE) (15) SLIDES (9) (2) (4) SURGICAL PATHOLOGY REPORT  LOCATION: PATHOLOGY NO. : HOSPITAL NO.: PATIENT'S NAME: ACCOUNT NO.: AgE/SEX/DOB: DATE RECEIVED: PHYSICIAN(S) : DATE REPORTED: COPY TO: DIAGNOSIS: PLEURA, LEFT, BIOPSY A. MALIGNANT NEOPLASM WITH FEATURES CONSISTENT WITH MESOTHELIOMA (PLEASE SEE COMMENT) . B. LUNG, BRUSHING BRONCHIAL EPITHELIAL CELLS WITH REACTIVE CHANGES.  NEGATIVE FOR MALIGNANCY. C. LUNG, WASHING BRONCHIAL CELLS WITH REACTIVE CHANGES. NEGATIVE FOR MALIGNANCY. commeNr: The biopsy displays fragments of fibroadipose tissue and skeletal. Printed by: Page 1 of 2 Printed on: (Continued)
+
+--- Page 2 ---
+muscle infiltrated by a poorly differentiated neoplasm formed by epithelioid cells with high nuclear grade. The neoplastic cells are positiye for S-100 while negative for carcinoembryonic antigen and Leu-M1 (as per immunohisto- chemistry performed at Additionally, immuno- revealed that the malignant cells. histochemistry performed at. are strongly positive for keratin, while negative for carcinoembyronic antigen,. B72.3, Ber-Ep4, and cD 15. Constellation of histological and immunohistochemical findings. are those of a malignant mesothelioma.. (15) SLIDES (9) (2) (4) SPECIMEN: A (1) BLOCK OPERATION: PRE-OP DIAGNOSIS: POST-OP DIAGNOSIS: CLINICAL DATA: are 15 slides and 1 ~GROSS DESCRIPTION: Received from block as labeled above.. PATHOLOGIST : Completed Action List: * Perform by Printed by: Page 2 of 2 Printed on: (End of Report)
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diff --git a/output/text/590b73ba-da67-4b5d-a2ac-84bd288e8fa3.txt b/output/text/590b73ba-da67-4b5d-a2ac-84bd288e8fa3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..85dc092fc73af540ed16c11c5111cc3000d2e871
--- /dev/null
+++ b/output/text/590b73ba-da67-4b5d-a2ac-84bd288e8fa3.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:454814C5-DD25-4249-85A6-71638DD756F7 TCGA-KQ-A41P-01A-PR Redacted Surgical Pathology Laboratory al Pathology Report In Lab Date: Report Date: Submitted by: ase is (ircle Telephone: Location: Copy To: CLINICAL INFORMATION: CA bladder. Specimen submitted: A. Bladder, prostate and seminal vesicle: B. Left pelvic lymph node; C. Left para aortic tissue; D. Right pelvic lymph node; E. Left distal ureter; F. Right distal ureter. DIAGNOSIS: A. Bladder, prostate gland, and seminal vesicles (radical cystoprostatectomy): Bladder: Invasive high grade urothelial carcinoma. Tumor grossly and microscopically invades through the muscularis propria into perivesical fat (pT3b). Invasive carcinoma is centered primarily in thc trigone and left lateral wall;. however, tumor also involves the right lateral wall, bilateral ureteral orifices,. and extends into the anterior and posterior walls. Foci of urothelial carcinoma in situ are present throughout the bladder.. Extensive vascular invasion is present, and metastatic tumor deposits are noted in perivesical soft tissue,. as well as within prostatic stroma (e.g., slides A46, A48; pM1). Perineural invasion is present. Tumor very focally abuts the inked anterior and posterior soft tissue resection margins.. Distal urethral and bilateral ureteral margins are negative for carcinoma. Prostate: Multifocal prostatic adenocarcinoma, Gleason score 3+3=6. Tumors are organ-confined and present as two microscopic foci,.  present in the right anterior para-apex (slide A38) and right anterior para-base (slide A50).. No angiolymphatic invasion by prostatic carcinoma is identified.. Seminal vesicles and all surgical margins are negative for prostatic carcinoma.. TNM (bladder): pT3b N3 MI icD-o 3 TNM(prostale): pT2a N0 Mx Si4c: PA4h:5Iaddcr,NOS cC).9 Comment: Given the extent of lymph node dissection (sce Parts B, C, and D), it is assumed that some of the nodes represent common iliac lymph nodes, which are considered secondary sites of regional lymph node drainage and staged as pN3. Please correlate with clinical and intraoperative findings to confirm the above pathologic "N" stage.. Pnge I oF 3
+
+--- Page 2 ---
+B. Lymph nodes, left pelvis (excision): Metastatic urothelial carcinoma involving all fourteen Iymph nodes (14/14). The largest tumor deposit measures at least 2.1 cm (microscopic). Extranodal extension of the carcinoma is identified. C. Para-aortic tissue, left (excision): Metastatic urothelial carcinoma involving all five lymph nodes (5/5). Tumor grossly spans the entire length of the specimen, which measured 7 cm in greatest extent. Extranodal extension of the carcinoma is identified. D. Lymph nodes, right pelvis (excision): Metastatic urothelial carcinoma involving all fifteen lymph nodes (15/15). The largest tumor deposit measures at least 1.9 cm (microscopic). Extranodal extension of the carcinoma is identified. E.Ureter, left distal (excision):. Segment of ureter with acute and chronic inflammation and reactive epithelial changes. No carcinoma identified. F.Ureter, right distal (excision):. Segment of ureter with acute and chronic inflammation and reactive epithelial changes. No carcinoma identified. GROSS DESCRIPTION: A. Received fresh, the specimen is labeled "bladder, prostate and seminal vesicles" and consists of bladder, prostate and semina! vesicles. The specimen measures 16 x 12 x 5.5 cm. The bladder measures 7.5 x 7.0 x 5.0 cm. The anterior aspect of the bladder is inked green and the posterior aspect of the bladder is inked black. The right ureter is 0.8 cm in length and 0.9 cm in diameter with a stent in place. The left ureter is 1.4 cm in length and 0.9 cm in diameter also with a stent in place. The specimen is opened from the anterior aspect of the prostate and bladder to reveal a 2.2 x 2.0 x 0.4 cm area of firmness with ulceration and necrosis in the arca of the bladder neck/trigone extending into the Iefl and right lateral walls. A section of the ulcerated area is submitted for research. The posterior wall mucosa adjacent to the ulcerated areas is polypoid and erythematous. The specimen is representatively submitted. The prostatectomy specimen includes a 4.5 x 4.5 x 3.0 cm prostate, a 4.5 x 1.7 x 1.0 cm left seminal vesicle, a 7.0 x 0.7 cm left vas deferens, a 4.0 x 2.0 x 1.0 cm right seminal vesicle and a 9.0 x 0.3 cm right vas deferens. The right side of the specimen is inked green, and the left side is inked black. The seminal vesicles and apical margins are shaved and submitted. The apical margin is shaved and submitted. The prostate is serially sectioned from the apex to base with sections designated from A to E, respectively. On sectioning, multiple nodular and cystic areas are seen. The prostate is submitted entirely. Summary of sections: A1-urethral margin; A2-right ureteral margin A3-left ureteral margin; A4-A7 representative bladder neck with ulcer (adjacent to the sections taken for research) ; A8-left UVJ area; A9-right UVJ area with ulceration; A10-prostatic urethra to bladder neck; A1 I-A13-anterior wall:; A14-A16-bladder neck with ulceration: A17-A18-posterior wall; A20-A22-left wall; A23-A25-right wall; A26-A28-dome: A29-A-31-trigone; A32-RSV; A33-LSV; A34-RA apex; A35-RP apex; A36-LA apex; A37-LP apex; A38-RA A; A39-RP A; A40-LA A; A41-LP A; A42-RA B; A43-RP B; A44-LA B; A45-LP B; A46-RA C; A47-RP C; A48-LA C; A49-RL C; A50-RA D; A51-RP D; A52-LA D; A53-LP D; A54-RA E; A55-RP E; A56-LA E; A57-LP E. (Note: R=Right; L=Lef; A=Anterior; P=posterior) B. Received fresh, the specimen is labeled "left pelvic lymph node" and consists of aggregate of red-tan sof tissue measuring 6 x 6 x 2 cm. The lymph nodes are entirely submitted. Summary of sections: B1-one lymph node; B2-B-one lymph node bisected; B4-two lymph nodes; B5-five lymph nodes; B6-B9-one lymph node bisected each cassette. C. Received fresh, the specimen is labeled "right paraaortic tissue" and consists of a 7 x 2 x 2 cm piece of firm fibrofatty tissue with multiple matted lymph nodes. The specimen is sequentiaily sectioned and entirely submitted. Summary of sections: Ct-C10. D. Received fresh, the specimen is labeled "right pelvic lymph node" and consists of a 4 x I x I cm aggregate of fat and lymph node. The lymph nodes are entirely submitted. Summary of sections: D1-one bisected lymph node; D2-D5-multiple intact lymph nodes. E. Received fresh, the specimen is labeled "left distal ureter" and consists of segment of ureter measuring I cm in length and 0.3 cm in diameter. There is stitch marking on one end. The specimen is entirely submitted. Summary of sections: E1-with stitch; E2. F. Received fresh, the specimen is labeled "right distal ureter" and consists of a segment of ureter measuring 4 cm in length and 0.8 cm in diameter. There is stitch marking on one end. The specimen is entirely submitted. Summary of sections: F1-F5-right dista! ureter (F1-with stitch). 1 Page 2 of 3
+
+--- Page 3 ---
+*** Electronically Signed Out *** Attending Pathologist The attending pathologist whose signature appears on this report has reviewed the dlagnostic slides. and has edited the gross and microscopic portions of the report in rendering the final disgnosis. Slides: A-57, B-9, C-10, D-5, E-2, F-5 Page 3 of 3 END OF REPORT
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diff --git a/output/text/5928ada8-95b8-4083-bf5e-f37d85470d66.txt b/output/text/5928ada8-95b8-4083-bf5e-f37d85470d66.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7f3453f4e29fcbae03fa267afc02c38665361f4e
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+DIAGNOSIS: 1. Kidney, right, tumor #1, excision: Renal cell carcinoma with features of papillary RCc type 1 with solid and. clear cell areas; see note. 2. Kidney, right, tumor #2, excision: Muitiple foci of renal cell carcinoma with features of papillary RCC type 1 with solid areas; see note. NOTE: The case will be discussed with. and a supplemental report will follow, if indicated CLINICAL INFORMATION: Brief Clinical History: with HPRC and right renal mass. Specimen Taken For Protocol: 01 - Yes Allocate Order to Protocol: PRocEDuRE: Operative Findings: two right renal masses Post-Operative Diagnosis: renal mass Pre-Operative Diagnosis: renal mass SPECIMENS SUBMITTED: 1. TUMOR, #1 2. TUMOR, #2 Right Kidney GRoss DEscRIPTION: Received for procurement labeled with the patient's name, medical record number, and further described as follows are:. 1. "Tumor #1" is a 1.1 x 1.1 x 1 cm white soft tissue fragment. The cut surface is tan homogeneous. 60% is procured for the a 0.1 cc amount is procured for electron microscopy, and the remainder is sent to Surgical Patient Identification
+
+--- Page 2 ---
+Pathology. At Surgica! Pathology, the specimen is received and matches the above description. It is serially sectioned and entirely submitted in cassette for permanent processing. 2. "Tumor #2 right kidney" is a 2.5 x 2.2 x 2 cm soft tissue fragment with a white/tan, variegated cut surface. Attached normal parenchyma is seen. 35% is procured the a 0.1 cc fragment is sent for electron microscopy, and the remainder is sent to At and matches the above description and is entirely submitted in cassette  for permanent processing.. The above procurement was performed by on No consultantse Patient Identification
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diff --git a/output/text/59295c54-0cfd-482f-a1ff-9974b3ec6bdf.txt b/output/text/59295c54-0cfd-482f-a1ff-9974b3ec6bdf.txt
new file mode 100644
index 0000000000000000000000000000000000000000..432b8a87202bd724f32e1823ce5ea098763b2060
--- /dev/null
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+
+--- Page 1 ---
+Pathology Report (A) LEFT KIDNEY: CHROMOPHOBE RENAL CELL CARCINOMA, FUHRMAN'S NUCLEAR GRADE 3. (SEE COMMENT) TUMOR CONFINED TO KIDNEY. TUMOR MEASURES 3.9 CM IN MAXIMUM DIMENSION Vascular, ureteral and soft tissue margins of resection, free of tumor.. COMMENT The tumor is friable and distorted clusters of tumor cells are present in artifactual clefts and spaces between the renal parenchyma and renal sinus adipose tissue. These areas are interpreted as representing artifactual displacement of tumor cells rather than true extension into the adipose tissue. Multiple additional deeper sections were examined. GROSS DESCRIPTION (A) LEFT KIDNEY - A nephrectomy specimen (12.0 x 6.5 x 5.0 cm) including the left kidney (10.5 x 5.5 x 4.0 cm), a segment of the renal artery and the renal vein (1.5 cm in length and 0.5 cm in average diameter) and ureter (13.0 cm in length and 0.2 cm in average diameter). There is a 3.9 x 3.4 x 1.5 cm well-circumscribed tumor in the upper pole of the kidney. The tumor is yellow-brown, abutting the renal sinus and appears to be confined to the kidney. The adjacent kidney parenchyma is unremarkable. The pelvicalyceal system is smooth and devoid of any lesions. No lymph nodes are identified in the hilum of the kidney. Portions of the tumor have been submitted for possible EM. Tumor is also submitted to the tumor bank. SECTION CODE: A1, renal artery and vein margin; A2, ureter margin; A3, tumor with adjacent uninvolved kidney; A4-A7, tumor with adjacent renal sinus and uninvolved kidney; A8, A9, tumor with adjacent uninvolved kidney; A10, tumor with adjacent uninvolved kidney and perinephric fat; A11, uninvolved kidney, representative section. CLINICAL HISTORY Left renal mass. SNOMED CODES
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diff --git a/output/text/59581b31-8035-4465-bce0-037878492f4b.txt b/output/text/59581b31-8035-4465-bce0-037878492f4b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..da2a87119c5341a7b7e4543d862b20c2383b41bf
--- /dev/null
+++ b/output/text/59581b31-8035-4465-bce0-037878492f4b.txt
@@ -0,0 +1,21 @@
+
+--- Page 1 ---
+Jcs-0-3 Carcionu nfiItuutinq ductrl Nos 8500/3 Sit:brstN0s'C50.9 s18/n h Diagnosis: A: Posterior margin, left breast, re-excision. - Skeletal muscle and fibroadipose tissue; no carcinoma identified B: Breast (300 grams), right, total mastectomy - Focal atypical ductal hyperplasia (slide B5) - Apocrine metaplasia - Microcalcifications present in association with benign breast ducts and lobules - Skin with seborrheic keratoses - No invasive or in situ carcinoma identified C: Breast, left, modified radical mastectomy Tumor type: Infiltrating ductal carcinoma with micropapillary features (two foci) Nottingham combined histologic grade: 3 Tubule formation score: 3 Nuclear Pleomorphism Score: 3 Mitotic count score: 3 Focality of tumor: Multifocal (two separate invasive tumor masses in lower inner quadrant, 1.9 cm apart) with intervening tissue showing lymphatic space invasion (see comment) UUID:D40D0424-E1DA-4AEF-AD00-126038E80218 Tumor size (greatest dimension): TCGA-AQ-A04H-01A-PR Redacted Mass #1: 2.5 cm Mass #2: 1.4 cm Lymphovascular invasion: Present, extensive. In Situ Component: Present In Situ Component type/Architecture pattern: Ductal carcinoma in situ, comedo and solid subtypes Lobular carcinoma in situ. In Situ Component nuclear grade: High grade (nuclear grade 3) In Situ Component necrosis: Present In Situ Component extent/size: In situ carcinoma comprises less than 10% of total tumor volume and is present in association with both masses as well as
+
+--- Page 2 ---
+being present in tissue between the masses Extensive intraductal component: Not identified Nipple involvement: Not identified Skin involvement: Not identified Margin status:. Invasive component: Infiltrating ductal carcinoma is less than 1 mm from the deep specimen margin (see comment) In Situ component: Ductal carcinoma in situ is 3 mm from the deep specimen margin Axillary lymph nodes: Total number with metastasis: 4 Total number examined: 15 Size of largest metastasis: 9mm Extracapsular extension: not identified Microcalcifications: not identified Other findings: Biopsy site changes in Mass #1 Fibroadenomatous changee Skin with seborrheic keratosis AJCC PATHOLOGIC TNM STAGE:pT2 pN2a pMx Note: This pathologic stage assessment is based on information available at the time of this report, and is subject to change pending clinical review and. additional information. Comment: Two foci of infiltrating ductal carcinoma are present, both in the lower inner quadrant. Grossly, these masses were separated by 1.9 cm of soft fibroadipose tissue. Histologically, the intervening tissue shows ductal carcinoma in situ and carcinoma present within lymphatic spaces. The smaller tumor is less than 1 mm from the posterior specimen margin in the mastectomy specimen; however, it is possible that this margin is superseded by the separately submitted ' posterior margin' (part A). The morphology of the invasive carcinoma from the two masses is similar, as is the morphology of the in situ carcinoma admixed with each mass. These two masses may represent two separate foci of invasion arising from ductal carcinoma in situ or may be arising from a focus of lymphovascular invasion (i.e., an  intramammary metastasis). The tumor stage is based on the larger of the two
+
+--- Page 3 ---
+masses. Immunohistochemical studies for estrogen receptor, progesterone receptor and HER-2/neu were performed on the biopsy specimen from the larger of the two  masses. Immunohistochemical analysis of the smaller tumor mass will be performed and the results will be reported in an addendum. Gross Description: Specimen A is received in a formalin-filled container labeled "left re-excision posterior margin, tumor clip posterior" and is a partially oriented 2.6 x 1.8 x 1.0 cm fragment of mainly brown/red muscle with some minimal adherent fibroadipose tissue. There is a clip on one surface indicating the margin. This surface is inked blue. The remainder of the specimen is inked black. Sectioning exhibits unremarkable red/brown muscle with minimal fibroadipose tissue. The specimen is serially sectioned and entirely submitted in blocks A1 and A2. Specimen B is received in a formalin-filled container labeled "right total mastectomy, stitch marks axillary tail". Specimen fixation: Formalin Time in fixative: 7 hours Type of mastectomy: Total, per the specimen container and requisition Size of specimen: 300 grams, 19 x 15.5 x 3.0 cm Orientation of specimen: There is a stitch marking axillary tail. At the time of tissue procurement triage, the specimen is inked as follows: anterior/green, posterior/purple, axillary tail (lateral)/yellow.. Skin ellipse dimensions: 18.5 x 4.2 cm. The lightly pigmented skin ellipse is remarkable for multiple brown papules from 2 to 13 mm in greatest dimension. Just superior lateral to the nipple, there is a 1.2 x 0.8 x 0.2 cm raised flesh colored papule identified. The remainder of the papules are somewhat flatter and some are macules. Nipple/areola: 1.5 cm / 2.7 cm. Axillary tail: Axillary tail is not well-delineated. The lateral  breast tissue is sectioned and no lymph node candidates are identified. Biopsy site: N/A
+
+--- Page 4 ---
+Residual tumor: N/A Location of tumor:. N/A Distance of mass/biopsy site from surgical margin: N/A Gross involvement of skin or fascia/muscle by tumor:. N/A Description of remainder of breast:. The entire specimen consists of yellow lobulated fibroadipose tissue separated by thin fibrous. septae. There is scattered dense white breast tissue throughout the entire. specimen. There are no abnormalities readily appreciated.. Other remarkable features: None Tissue submitted for special investigations: Normal given to tissue procurement. Digital photograph taken: Block Summary: B1 - Nipple B2  - Section from largest raised papule (larger section), smaller section. through smaller papule B3-B4  - Inner upper quadrant B5-B6  - Inner lower quadrant B7-B8  - Outer upper quadrant B9-B10  - Outer lower quadrant B11-B12 - Central mastectomy B13-B14 - Lateral breast tissue Specimen C: Specimen fixation: Formalin Time in fixative: 7 hours Type of mastectomy: Modified radical per the specimen requisition Size of specimen:. 400 grams, 19 x 15 x 3.0 cm Orientation of specimen: Skin ellipse dimensions: 19 x 5.0 cm. The lightly pigmented skin. ellipse is remarkable for scattered light brown to medium brown papules from 3 mm to 1.3 cm in greatest dimension. .
+
+--- Page 5 ---
+Nipple/areola: 1.5 cm/ 3.5 cm. These structures are. unremarkable. Axillary tail: Axillary tail is 8 x 6.5 x 1.8 cm. The.  axillary tail is amputated and palpated for lymph node candidates. Multiple. lymph node candidates are identified from 4 x 4 x 3 mm to 1.5 x 1.0 x 0.6 cm. Biopsy site: N/A Residual tumor: Present. There are two lesions identified. The first lesion is 2.5 x 1.2 x 1.0 cm. This lesion is well-circumscribed and has a tan/red, focally hemorrhagic cut surface. This lesion is found within a background of dense white breast tissue. There is a second 1.4 x 1.2 x 1.0 cm. mass identified. This mass is also well-circumscribed and has a firm red/white. cut surface. These masses are 1.9 cm from one another. Mass #1 is slightly inferior to the. nipple in the subareolar region. Mass #2 is inferior and posterior to mass #1. Location of tumor: See above. Both masses are found in the inner lower quadrant. Distance of mass/biopsy site from surgical margin: Mass #1 2.4 cm to the deep purple inked margin, 5 mm to the skin, 4.1 cm to the inferior margin, approximately 6 cm to the medial margin, approximately 8 cm to the superior margin and distal to the lateral margin. Mass #2 is very close to the purple inked posterior margin, is approximately 3 cm to the inferior margin, at least 10 cm to the superior margin, approximately 5.6 cm to the medial margin and distant to the lateral margin. Mass #2 is 3.4 cm to the green inked anterior margin. Gross involvement of skin or fascia/muscle by tumor: N/A Description of remainder of breast:. The remainder of the mastectomy specimen consists of yellow lobulated fibroadipose tissue separated by thin fibrous septae. There is dense firm white breast tissue scattered throughout the entire specimen. Other remarkable features: None Tissue submitted for special investigations:. Tumor and normal given to tissue procurement.. Digital photograph taken:
+
+--- Page 6 ---
+Block Summary: C1 - Nipple C2  - Representative sections of epidermal papules C3  - Section from edge of mass #1 (larger) and mass #2 (smaller mass); and the section mass #2 is abutting purple ink and mass #1 is cut through. C4 - Additional medial mass #2 C5  - Additional lateral mass #2 C6  - Additional fibroadipose tissue between masses C7 - Inferior margin closest to both masses, en face C8-C9 - Mass #1 and skin, slice bisected C10 - Mass #1 and adjacent breast tissue (purple ink does not denote true margin) C11 - Additional mass #1 and adjacent breast tissue (purple ink does not denote true margin) C12  - Deep margin closest to mass #1, en face C13  - Inner upper quadrant C14  - Inner lower quadrant C15  - Outer upper quadrant C16 - Outer lower quadrant C17 - Three lymph node candidates C18 - One lymph node candidate, trisected (suspicious) C19 - One lymph node candidate, trisected C20 - Largest lymph node candidate, sectioned C21 - One lymph node candidate, trisected C22 - One lymph node candidate, bisected C23 - One lymph node candidate, sectioned C24 - One lymph node candidate, sectioned C25  - One lymph node candidate, sectioned C26  - Multiple suspected lymph nodes C27  - One lymph node, serially sectioned Procedures/Addenda: Addendum Addendum The following addendum is issued to report the results of estrogen receptor, progesterone receptor, and HER2/neu immunohistochemical studies. Results: Estrogen receptor (Ventana, clone SP1): Interpretation: POSITIVE Computer-assisted quantitative score: 97% Progesterone receptor (Ventana, clone 1E2): Interpretation: POSITIVE
+
+--- Page 7 ---
+Computer-assisted quantitative score: 27% HER2/neu ( clone 4B5, FDA-approved): Interpretation: INDETERMINATE Computer-assisted quantitative score: 2+ (see comment) Site: Left breast Performed on block: C3 Fixation: 10% neutral buffered formalin. Fixation time: 6-48 hours. Reference range: Estrogen receptor and progesterone receptor: <1%=NEGATIVE, 1-10% WEAK POSITIVE, >10% POSITIVE HER2/neu: 0,1=NEGATIVE FOR OVEREXPRESSION, 2-INDETERMINATE, 3=POSITIVE FOR OVEREXPRESSION Comment: The auantitative scores reported above were obtained using the FDA-approved  The control slides for this case show. appropriate staining. The patient' s larger tumor was sampled and tested previously, which showed a similar pattern of immunohistochemical staining for HER-2/neu. Subsequent in situ hybridization studies for HER-2/neu gene amplification on that specimen showed that the. tumor was positive for Her-2/neu gene amplification. In situ hybridization studies can be repeated on the current specimen, if clinically desired.. Some of the immunohistochemical reagents used in this case may be classified as. analyte specific reagents (ASR) or research use only (RUO) reagents. These were developed and have performance characteristics determined by the. These reagents have not been cleared or approved by the US Food and Drug Administration (FDA). The FDA has determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational. or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA-88) as qualified to perform high complexity clinical laboratory testing.
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diff --git a/output/text/59593820-8922-476a-96d5-48b22c0bab4e.txt b/output/text/59593820-8922-476a-96d5-48b22c0bab4e.txt
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index 0000000000000000000000000000000000000000..648d0c9417b49ad37643ed2bd96531aeb85080cb
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+
+--- Page 1 ---
+Clinical Diagnosis & History: y/o female with multicentric invasive cA of left breast (2 foci, at 3:00 and S:00). For left total mastectomy, SLNB, possible ALND. Specimens Submitted: UUID:467172CC-6EA1-435D-BDC1-D65FBF8EA0E8 TCGA-A0-A1KP-01A-PR Redacted 1: SP: Sentinel node #1, level 1, 1t. axilla (fs). 2: Sp: Sentinel node #2, level 1, lt. axilla (fs). 3: sp: Non sentinel tissue, lt. axilla. 4: SP: Lt. total mastectomy DIAGNOSIS: 1) LYMPH NODE, SENTINEL #I. LEVEL I, LEFT AXILLA; EXCISION: -ONE LYMPH NODE POSITIVE FOR METASTATIC CARCINOMA (1/1) (SEE NOTE) - THE METASTATIC FOCUS MEASURES O.3 CM. EXTRANODAL EXTENSION IS IDENTIFIED. /cb-0- 3 NOTE: THE METASTATIC TUMOR IS NOT PRESENT ON THE FROZEN SECTION SLIDE AND Corcinomn,nfiltnatNg ouctl N0s 85o0f3 APPEARS ONLY ON THE DEEPKR PERMANENT SECTION.S S.+e busot, Nos c50.9 2) LYMPH NODE, SENTINEL #2, LEVEL I, LEFT AXILLA; EXCISION: -ONE BENIGN LYMPH NODE O/1). i LYMPH NODE, NON-SENTINEL TISSUE, LEFT AXILLA; BICISION: 3 ONE BENIGN LYMPH NODE (O/1). - BENIGN FIBROADIPOSE TISSUE. 4) BREAST, (LEFT; TOTAL HASTECTOMY: - MULTIPLE FOCI OF DNVASIVE DOCTAL CARCIMOKO, NOS TYPE. HISTOLOGICS GRADE II/III (MODERATE TOBULE FORMATION). NUCLEAR GRADE II/III (MODERATE VARIATION IN SIZE AND SHAPE). RANGING IN SIZE FROM O.3 CK UP TO 1.8 CM. - DUCTAL CARCINOMA IN SITU (DCIS) IS ALSO IDENTIFIED, SOLID AND MICROPAPILLARY TYPES WITH INERMDIATE NUCLEAR GRADE AN MODERATE NECROSIS. - THE DCIS CONSTITUTES <- 25S OF THE TOTAL TUMOR MASS, AND IS PRESENT ADMIXED WITH TER INVASIVE COMPONENT. - THE INVASIVE CARCINONA IS LOCATED IN THE LOWER INNER QUADRANT AND THE AREA BETWEEN THE LOWER OUTER QUADRANT AND LOWER INNER QUADRANT.  NO INVOLVEMENT OF THE NIPPLE BY EITHER IN SITU OR INVASIVE CARCINOMA IS IDENTIPIED.S Continued on next page D!SQUAUFJF
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+--- Page 2 ---
+-- Page 2 of 5  CALCIFICATIONS ARE PRESENT IN BOTH THE IN SITU AND INVASIVE CARCINOMA. - VASCULAR INVASION IS PRESENT. - NO INVOLVEMENT OF THE SURGICAL MARGINS BY EITHER INVASIVE OR IN SITU CARCINOMA IS IDENTIFIED. - NO SKIN INVOLVEMENT BY CARCINOMA IS IDENTIFIED.S - THE ATTACHED SKELETAL MUSCLE IS NEGATIVE FOR TUKOR.S : THE NON-NEOPLASTIC BREAST TISSUE SHOWS APOCRINE METAPLASIA AND COLUMNAR CELL ALTERATION. -RESULTS OF SPECIAL STAINS ER, PR, HER2-NEU) WILL BE REPORTED AS AN ADDENDUM. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL). AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. -. Roport Electronically Signed Out Special Studies: Result Special Stain Comment ER-C PR-C HER2-C NEG CONT IMM RECUT NEG-HER2 1) The specimen is xeceived fresh for frozen section, labeled -Sentinel. Node #l Level 1 Left Axilla". It consists of a 1 x 1 x 0.6 cm lymph node.. The lyuph node is bisected and entirely frozen. Summary of Sections: FSC - frozen section control 2) The specimen is received fresh fox frozen section, labeled -Sentinel. Node #2 Levei 1 Loft Axilla*. It consists of a 1 x 0.7 x 0.6 cm tan lymph node. The lymph node is bisected and antirely frozen.. Summnaxy of Sections: FSC - frozen section control 3) The specimen is received in formalin, labeled "Non-sentinel Tissue ** Continued on next page **
+
+--- Page 3 ---
+Left Axilla". - Page 3 of 5 x 1 x 0.5 cm and 3 x 1.5 x i cm. Two possible tan lymph nodes measuring 0.2 and 0.8 cm in greatest dimension axe identified. submitted. The specimen is antirely Summary of Sections: LN - lymph node BLN - bisected lymph node remainder of fat 4) The spacimen is received fresh, labeled -Left Total Mastectomy (stitch marks mxillary aspect)*. It consists of a breast measuring 28 x 27 x 4.5 cm and weighing 1.750 grams.. A suture designates the axillary aspect Of the spacimen.  Identified on the anterior surface is a light tan skin ellipse measuring 24 x 12 cm. No scars are identified on the epidermal identified. The entire deep resection margin is inxed.  Identified on the. deep aspect is a 6 x 2.5 x 2 cm defect near the axillary aspect of the specimen.  Sarial sections through the specimen reveal two distinct tumor. masses in the lower inner quadrant and one separate tumor lower inner and lower outer quadrants. The two masses in the lower inner quadrant are fairly well-circumscribed. firm, spiculated with focal axeas necrosis and measure 2 x 1 x 1 cm and 1.3 x 1 x 1 cm.. Of The larger tumor mass from the closest superficial resection margin. The smaller tumor mass in tho lower inner guadrant is at a distance of 5 cm from the closest deep resection margin and 4 cm from the closest anterior resection margin. tumor mass located between the lower inner and lower outer quadrants is The well-circumscribed, firm, tan and measures 0.7 x 0.5 x 0.s cm and in located at a distance of 5 cm from the closest deep resection maxgin..  The remainder of the parenchyma is comprised of approximately 54 tan-white fibrous tisaue and 95% yellow-tan adipose tissue. 'A portion of the largest tumor is submitted for Tps studies. The tumors are entirely submitted.. Summary of Sections: N nipple S skin  larger tumor in the lowor inner quadrant TS  smaiier tumor in tha lower inner quadrant DL deep margin closest to larger tumor. AL anterior margin closest to larger tumor ps deep margin closest to smaller lower inner quadrant tumor AS  anterior margin closest to smaller lower inner quadrant tumor TIO "tumor batween lower inner and lower outer quadrant deep margin closest to tumor between lower inner and lower outer. quadrants AM - anterior margin closest to tumor batween lower inner and lower outer quadrants UoQ - upper outer quadrant LOQ lower  outex quadrant UIQ . upper inner quadrant LIQ - lower inner quadrant *. Continued on next page **
+
+--- Page 4 ---
+Summary of Sections: Part 1: SP: Sentinel node #1, level 1, It. axilla (fs) Block Sect. Site pCs 1 fsc 1 Paxt 2: Sp: Sentinel nod. #2, level 1, lt. axilla (fs) Block Sect. Site PCs fsc 1 Part 3: SP: Non sentinel tissue, It. axilla Block Sect. Site PCs 14 BLN 2 2 1 Part 4: Block Sect. site PCs 1 aL 1 1 H 1 22 LIQ 2 2 2 LOQ 1 1 12 22 DIQ UOO Procedures/Addenda : Addendum Date Ordered: Status: Signed Out Date Complete: By: Date Reported: Addendum Diagnosis ADDENDUM + Continued on next page -
+
+--- Page 5 ---
+Page SITE: BREAST, LEFT. TOTAL MASTECTOMY PART #4. ER: POSITIVE (ABOUT SO% OF NUCLEAR STAINING WITH STRONG INTENSITY) PR: POSITIVE (ABOUT 4O% Or NUCLEAR STAINING WITH STRONG INTENSITY). HER2/NEU (HERCEPTEST) : NEGATIVE (STAINING INTENSITY OF I+). Intraoperativs Consultation: Note: issue sample examined at the time of the intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS: BenIgn. PERMANENT DIAGNOSIS: SEE FINAL DIAGNOSIS. 2) FROZEN SECTION DIAGNOSIS: BENIGN. PERMANENT DIAGNOSIS: SAME. End of Report
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diff --git a/output/text/5961eceb-05f8-4dad-8586-329cd4be367e.txt b/output/text/5961eceb-05f8-4dad-8586-329cd4be367e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..99bf8b85a7301e2fb34c72e8024732140feae7ba
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+PATIENT hISTORy: The patient is a  A colonoscopy showed partially obstructing fungating tumor of the left colon close to splenic fexure. No other abnormalities seen. Bowel prep was suboptimal as a result of. partial obstruction of poor bowel prep, evaluation yas not continued. Biopsy of this lesion revealed adenocarcinoma. PRE OP DIAGNOSIS: Colon cancer. ** Post op Diagnosis: Same. PROCEDURE: Not given, ADDENDA: Addendum At the request of 4 EGFR immunostaining was performed on a section of the colon cancer (slide 1H). The immunohistochemical stain for EGFR is negative, but this interpretation is based on an altered method (an original H&E stained slide from this case had to be detstained in order to be stained for EGFR, a process that could potentially interfere with the immunohistochemical reaction). Thus, an additional EGFR stain has been requested on this patient's metastatic tumor and is pending; the results will be reported as an addendum of FINAL DIAGNOSIS: PArT 1 And 2: Large intestine, partial resecton with subsequent revision of "new proximal. margin" -  A.  INVASIVE MODERATELY DIFFERANTIATED COLONIC ADENOCARCINOMA EXTENDING THROUGH THE muscularis propria Into the serosal Adipose tissue. Diameter 6.5 Cm. nO evidence Of Angiolymphatic Invasion. PiErineural invasion IdentifieD. All. margins Free. pathologiC STage t3nomx, dukes' b, Astler cOller b2. B. Twelve (12) pericOLonic LymRh nODes wIth nO eviDence Of metastaTiC cARcinomA.
+
+--- Page 2 ---
+MICROSCOPIC: SyNopTIC Primary COLOn AnD rECTal TUmORS A. Location: 5 1. Ileocecal Region 4.  Descending Colon 2. Ascending Colon 5. Sigmoid Colon 3. Transverse Colon 6. Rectum B Procedure: 1 1.  Segrnental Colectomy 3. Other 2. Total Colectomy C. Size of Tumor (maximum dimension): 6.5 cm D. Type: 1 1. Adenocarcinoma, NOs 9. Squamous Cell Carcinoma 2. Adenocarcinoma arising in a backgroun 10. Undifferentiated Carcinoma of an adenoma. 11. Sarcoma 3.  Adenocarcinoma arising in a backgroung 12. Smooth Muscle Tumor of inflammatory bowel disease 13. Gastrointestinal stromal tumor 4. Adenosquamous carcinoma 14. Lymphoma 5. Carcinoid Tumor (Neuroendocrine Tumg) 15. Other 6.  Mucinous Adenocarcinoma Signet ring cell type Adenocarcinoma 8. Neuroendocrine Carcinoma Grade: 2 1. Well differentiated 2. Modergtely differentiated 3. Poorly differentiated F. Extent of Intiltration:  Limited to the mucosa. 4. Infiltrating through muscularis propria into serosal Into submucosa adipose tissue  Involving muscularis propria 5.  Invotving adjacent organs/ pelvic wall Angiolymphatic Invasion:  2 G. 1. Yes 2. No H. Surgical Margins Involved: 2 1. Yes 2. No 1.  Regional Lymph Node Involvement: 2 1. Yes 2. No J. If regional lymph nodes involved, Number positive/number examined: N/A. K. Extracapsular spread : N/A Yes 2.No. Associated conditions: N/A 1. Ulcerative colitis. 2. Crohns Disease. 3. History/ presence of adenomatous polyps 4. Multiple polyposis syndromes. 5. Diverticulosis. M. Tnm Stage: t3 nQmx N.Dukes' Stage: 2 1. A (limited to mucosa and muscularis) 2.  B.(through muscularis into subserosa) C (through subserosa and involving adjagent organ/pelvic wall/regional or distant lymph nodes) O. Astler - Coller Stage: 3 1. A (mucosa but not into muscularis propr 2.  B1 (muscularis propria but not through, N negative) 3.  B2 (through muscularis propria into subserosal fibroadipose tissue, LN negative). 4. C1 (limited to muscularis propria but notthrough serosa, LN positive). 5. C2 (invades serosal adipose tissue, LN positive)
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diff --git a/output/text/5962a143-e5da-4dc5-9057-6e424591a09f.txt b/output/text/5962a143-e5da-4dc5-9057-6e424591a09f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4ef7e9010f0def2efcada36f1b811909d8393e20
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+RUN DATE . UUID:792A24F5-065E-4001-97F6-3F9BA121C65D0 TCGA-EW-A2FR-01A-PR Redacted PAGE 1 RUN TIME: Path #: Received: Collected: Copies to: Submit Dr: 1cs-0- 3 Cerciioma, vifiltratny duct, NUs 8500/3 Sit: breot Nos cs0.9 lw b/Ju SPECIMEN ID: A. - RIGHT BREAST MASS, B. . - ADDITIONAL RIGHT BREAST TISSUE, INFEROLATERAL, C. - ADDITIONAL RIGHT BREAST TISSUE, SUPERFICIAL, D. . - RIGHT AXILLARY CONTENTS A. RIGHT BREAST MASS: INVASIVE AND IN SITU, POORLY DIFFERENTIATED DUCTAL CARCINOMA, 1.O CM.S  THE TUMOR CELLS ARE NEGATIVE FOR er AND pr AND EQUIVOCAL FOR HER2 BYS IMMUNOHISTOCHEMISTRY PERFORMED ON PATIENT'S PREVIOUS BIOPSY (S i). - HER2 WITH FTSH TS AMDT,IFIED (POSITIVE), PERFORMED ON PATIENTS'S PREVIOUS BIOPSY  SEE TUMOR SUMMARY. B. ADDITIONAL RIGHT BREAST TISSUE INFEROLATERAL:  INVASIVE DUCTAL CARCINOMA AT LESS THAN 1.O MM EROM INKED MARGIN.S C. ADDITIONAL RIGHT BREAST TISSUE SUPERFICIAL: - NO CARCINOMA SEEN IN FIBROADIPOSE TISSUE. D. RIGHT AXILLARY CONTENTS: - METASTATIC CARCINOMA TO NINETEEN OUT OF TWENTY-ONE LYMPH NODES (19/21).  PERINODAL TUMORAL EXTENSION IS SEEN. LARGEST METASTATIC NODE: 2.5 CM  SEE TUMOR SUMMARY. BREAST CANCER SUMMARYS SPECIMEN TYPE: LUMPECTOMYS This report is privileged, confidential and exempt from disclosure under applicable law. If you receive this report inadvertontly, please call and return the report to us by mail..
+
+--- Page 2 ---
+RUN DATE: PAGE 2 RUN TIME: *** FINAL REPORT *** SURGICAT. DATHOLOGY REPORT ... ** * FINAL DIAGNOSIS *** (Continuad) LYMPH NODE SAMPLING: AXILLARY DISSECTION SPECIMEN SIZE: GREATEST DIMENSION: 9.3 CMS ADDITIONAL DIMENSIONS: 9.0 X 6.5 CM LATERALITY: RIGHT TUMOR SITE: NOT SPECIFIED SIZE OF INVASIVE COMPONENT: GREATEST DIMENSION: 1.O CM HISTOLOGIC TYPE: INVASIVE DUCTAL CARCINOMA NOTTINGHAM SCORE: III (3+3+3-9) TUBULE FORMATION: MINIMAL LESS THAN 1O% (SCORE 3) NUCLEAR PLEOMORPHISM: MARKED VARIATION IN SIZE, NUCLEOLI, CHROMATIN CLUMPING, ETC (SCORE 3) MITOTIC COUNT: GREATER THAN 2O MITOSES PER 10 HPF (SCORE 3) PRIMARY TUMOR: pTIb - TUMOR MORE THAN O.5 CM BUT NOT MORE THAN 1.O CM IN GREATEST DIMENSION REGIONAL LYMPH NODES: pN3a - METASTASIS IN 1O OR MORE AXILLARY LYMPH NODES (AT LEAST 1 TUMOR DEPOSIT GREATER THAN 2.O MM) OR METASTASIS TO THE INERACLAVICULAR LYMPH NODES NUMBER EXAMINED: 21 NUMBER INVOLVED: 19 DISTANT METASTASIS: pMX - CANNOT BE ASSESSED MARGINS: MARGINS UNINVOLVED BY INVASIVE CARCINOMA. CLOSEST MARGIN: AT LESS THAN 1 MM (INFEROLATERAL MARGIN ) (SPECIMEN B) MARGINS UNINVOLVED BY DCIS. CLOSEST MARGIN: AT LESS THAN 1 MM (INFEROLATERAL MARGIN) (SPECIMEN B) VENOUS/LYMPHATIC INVASION: ABSENT MICROCALCIFICATIONS: PRESENT IN DCIS AJCC: pT1b, N3a, MX IMMUNOHISTOCHEMISTRY STAINS AND HER2 FISH ANALYSIS PERFORMED ON PATIENT'S PREVIOUS BIOPSY RESULTS: ER NEGATIVE PR -  NEGATIVE HER2 IHC  EQUIVOCAL HER2 BY FISH - 1 POSITIVE (AMPLIFIED) This report is privileged, confidential and exempt from disclosure under applicable lax. If you receive t this report inadvortently, please call.. and return the report to us by mail..
+
+--- Page 3 ---
+ RUN DATE: PAGE 3 RUN TIME: *** FINAL REPORT *** SURGICAL PATHOLOGY REPORT CLINICAL HISTORY- PRE-OP DX:  RIGHT BREAST CARCINOMA PROCEDURE:  RIGHT BREAST LUMPECTOMY, AXILLARY LYMPH NODE DISSECTION, GROSS DESCRIPTION: SPECIMEN A IS LABELED RIGHT BREAST MASS AND CONSISTS OF YELLOW-GRAY LUMPECTOMY MEASURING 9.3 X 9.0 X 6.5 CM AND WEIGHS 75.7 GRAMS.  THE SPECIMEN IS ORIENTED WITH A SHORT STITCH AT THE SUPERIOR MARGIN, A LONG STITCH AT THE LATERAL MARGIN AND CLIP INFEROLATERAL CORNER. THE SPECIMEN REVEALS A LIGHT TAN ELLIPSES OF SKIN MEASURING 3.5 X O.8 CM. THE SPECIMEN IS INKED AS FOLLOWS: SUPERIOR MARGIN INKED RED, INFERIOR MARGIN INKED ORANGE, LATERAL MARGIN INKED GREEN, MEDIAL MARGIN INKED BLUE, INFEROLATERAL MARGIN INKED YELLOW AND DEEP MARGIN INKED IN BLACK. MULTIPLE CROSS SECTIONS REVEAL AN ILL-DEFINED, GRAY-PINK, INDURATED AREAS MEASURING APPROXIMATELY 1.O X 1.O CM. THIS AREA IS LOCATED AT O.7 CM FROM THE INFERIOR MARGIN (NEAREST). THERE IS AN ILL~DEFINED, GRAY-PINK MICROCYSTIC ASPECT LOCATED AT O.3 CM FROM THE INFEROLATERAL MARGIN (NEAREST). THE REST OF THE SPECIMEN IS YELLOW, HOMOGENOUS CUT SURFACE.  THE STROMA IS SUBMITTED IN TOTO IN 16 CASSETTES.  SUPERIOR MARGIN INFEERIOR MARGIN LATERAL MARGIN  MEDIAL MARGIN - ANTERIOR MARGIN DEEP MARGIN 7-12 - TUMOR 13-16 -- CLIPPED AREA SPECIMEN B IS LABELED ADDITIONAL RIGHT BREAST TISSUE, INFEROLATERAL MARGIN AND CONSISTS OF YELLOW-PINK ADIPSOSE TISSUE MEASURING 3.5 X 1.5 X 0.7 CM. THE NEW MARGIN IS INKED YELLOW AND THE OPPOSITE MARGIN IS INKED ORANGE. MULTIPLE CROSS SECTIONS REVEAL A GRAY-PINK, INDURATED AREA MEASURING 1.O CM. THE REST OF THE TISSUE IS YELLOW, HOMOGENEOUS CUT SURFACE. SUBMITTED IN TOTO IN FIVE CASSETTES. SPECIMEN C IS LABELED ADDITIONAL RIGHT BREAST TISSUE, SUPERFICIAL AND CONSISTS OF THREE YELLOW-PINK, ADIPOSE TISSUE MEASURING IN AGGREGATE 3.O X 2.0 X 1.0 CM. CROSS SECTIONS REVEAL YELLOW-GRAY, HOMOGENEOUS CUT SURFACE. SUBMITTED IN TOTO IN THREE CASSETTES. SPECIMEN D IS LABELED RIGHT AXILLARY CONTENTS AND CONSISTS OF GRAY-PINK, ADIPOSE TISSUE MEASURING 9.0 X 7.0 X 3.5 CM. CROSS SECTIONS REVEAL 28 POSSIBLE LYMPH NODES MEASURING UP TO 2.5 CM IN GREATEST DIMENSION. REPRESENTATIVE SECTIONS SUBMITTED IN 14 CASSETTES. 1-2 - ONE LYMPH NODE BISECTED 3-8 - ONE LYMPH NODE BISECTED 9 - THO LYMPH NODES BISECTED 10-14 - MULTIPLE LYMPH NODES This report is privileged, confidential and oxompt from disolosure under applicable law. If you receive this report inadvertently, please call. and return the report to us by mail..
+
+--- Page 4 ---
+RUN DATE: PAGE 4 RUN TIME: *** FINAL REPORT *** SURGICAL PATHOLOGY REPORT GROSS DESCRIPTION: (Continued) This report is privileged, confidential and exempt from disclosure undor applicable law. If you  receive this report inadvertently, please call and return the report to us by mail.
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diff --git a/output/text/59a9c2d7-7e5b-4cb0-89ff-12ec250f41db.txt b/output/text/59a9c2d7-7e5b-4cb0-89ff-12ec250f41db.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c383e777b2681a5cc01d2223132151152c784424
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+UUID:C0A8A457-8790-4745-BD5D-AFBE55254A1C Redacted Final Diagnosis Breast, right, wide local excision: Infiltrating ductal carcinoma, Nottingham grade II (of IIl) [tubules 3/3, nuclei 2/3, mitoses 1/3, Nottingham score 6/9], forming a 1.3 x 1.1 x 1.0 cm mass. Ductal carcinoma in situ is absent. An intramammary lymph node present is negative for metastatic carcinoma. Angiolymphatic invasion is absent. The non-neoplastic breast parenchyma shows nonproliferative fibrocystic changes. Biopsy site changes present. All surgical resection margins are negative for tumor. (minimum tumor free margin, 0.5 cm, deep margin). (AJCCpT1c) Lymph nodes, right axillary sentinel, excision: Multiple (2) sentinel lymph nodes are negative for metastatic carcinoma [AJCC pN0(i-)(sn)]. Blue dye is identified in sentinel lymph node No. 1 only. Immunohistochemical cytokeratin stain was performed on the paraffin embedded sentinel lymph node tissue and confirms the H&E impression.. Lymph node, right intramammary, excision: A single intramammary lymph node is negative for metastatic carcinoma.. Lymph node, right axillary, excision: A single right axillary lymph node is negative for metastatic carcinoma. HER2/neu ordered. 1cs-0-3 carcinonr, mfiPtratsg ouct Nos 850s/3 Sit: brst Nos c50.9 hs
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diff --git a/output/text/59d00a62-f86e-4e88-99a6-b789279685c4.txt b/output/text/59d00a62-f86e-4e88-99a6-b789279685c4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..dce8b20208167e425250c3affb1f255711126ae7
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+--- Page 1 ---
+LcD-o-3 SPECIMEN: SURGICAL PATHOLOGY REPORT '8Qdy 3it O%urey NoS DOB:  C649 Sex: F VtO 6/q413 Location: Date Collected Date Received UUID:040C3F06-62E5-4287-A499-3BB36C4BAD08 TCGA-AL-A5D3-01A-PR  Physician Redacted Copy To: Clinical History/Diagnosis: Left renal mass. Source of Specimen(s): 1: Left Kidney Mass 2: Nodes at Hylum 3: Fat at Diaphragm 4: Anterior Margin 5: Medial Lymph Node Dissection at Apex. 6: Retroperitoneal Lymph Nodes 7: Left Ureter 8: Left Kidney Final Diagnosis: ****AMENDED REPORT**** This amended report is issued to correct the source of specimen in part #1 to left kidney per The requisition slip was incorrectly labeled from the operating room. 1. Left kidney, biopsy: - High grade carcinoma. 2. Soft tissue at hilum, excision: - Fatty tissue with high grade carcinoma - Lymphoid tissue not identified. 3. Fat at diaphragm, excision: - Fatty tissue with no tumor seen. 4. Anterior margin, biopsy: - Fatty tissue with no tumor seen 5. Medial soft tissue at apex, excision: - Fatty tissue with no tumor seen. 6. Retroperitoneal soft tissue, excision: - Fatty tissue with no tumor seen. 7. Left ureter, ureterectomy: Prir tyroid caseey - - No tumor seen.. trutmet unkrony by T3S. w.3islis
+
+--- Page 2 ---
+8. Left kidney, total nephrectomy: - High grade renal cell carcinoma, papillary type II, 6.7 cm.. - Tumor invades through the kidney into the perirenal fat.. - Vein invasion is identified. - Vascular and ureteral margins with no tumor seen.. - pTNM: T3a Nx Mx Note: Immunohistochemical stains performed with good positive and negative controls show tumor cells focally positive for RCC, CK19 and. vimentin. They are negative for CD10, keratin903, CK5/6 and CD117. This profile is consistent with papillary carcinoma of kidney. These tests were developed and their performance characteristics determined by the immunohistochemistry laboratory at the These tests have not been cleared or approved by the U.S. Food. and Drug Administration. The FDA has determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1998 (CLIA) as qualified to perform high complexity clinical testing. ****ORIGINAL REPORT**** 1. Right kidney, biopsy: - High grade carcinoma. 2. Soft tissue at hilum, excision: - Fatty tissue with high grade carcinoma.. - Lymphoid tissue not identified. 3. Fat at diaphragm, excision: - Fatty tissue with no tumor seen.. 4. Anterior margin, biopsy: - Fatty tissue with no tumor seen. 5. Medial soft tissue at apex, excision:. - Fatty tissue with no tumor seen.. 6. Retroperitoneal soft tissue, excision:. - Fatty tissue with no tumor seen. 7. Left ureter, ureterectomy: - No tumor seen. 8. Left kidney, total nephrectomy: - High grade renal cell carcinoma, papillary type II, 6.7 cm.. - Tumor invades through the kidney into the perirenal fat. - Vein invasion is identified. - Vascular and ureteral margins with no tumor seen.. - pTNM: T3a Nx Mx
+
+--- Page 3 ---
+Note: Immunohistochemical stains performed with good positive and. negative controls show tumor cells focally positive for RCC, CK19 and. vimentin. They are negative for CD10, keratin903, CK5/6 and CD117. This. profile is consistent with papillary carcinoma of kidney.. These tests were developed and their performance characteristics. determined by the immunohistochemistry laboratory at the. These tests have not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. These tests are used for clinical purposes.. They should not be regarded as investigational or for research. This. laboratory is certified under the Clinical Laboratory Improvement. Amendments of 1998 (CLIA) as qualified to perform high complexity clinical testing. Gross Description: Received in eight parts.. Source of Tissue: 1. Labeled #1, "left kidney mass" Intraoperative Consultation: UROTHELIAL CARCINOMA PER DR. : Gross Description: Received fresh labeled "left kidney mass". It consists of a soft red. brown irregular tissue fragment measuring 1 x 1 x 0.3 cm. Entirely frozen in 1FS *** Source of Tissue: 2. Labeled #2, "nodes at hilum". Gross Description: Received fresh labeled "nodes at hilum". It consists of two soft. yellow-tan irregular fibrofatty tissue fragments measuring 1.5 x 1 x 0.5 cm. The specimen is sectioned to reveal a soft yellow-tan fibrofatty cut surface. Entirely. submitted in cassette 2A. *********** Source of Tissue: 3. Labeled #3, "fat at diaphragm" Gross Description: Received fresh labeled "fat at diaphragm". It consists of three soft. yellow-tan irregular fibrofatty tissue fragments measuring 1.2 x 1 x 0.5 cm in. aggregate. Entirely submitted in cassette 3A. *** Source of Tissue: 4. Labeled #4, "anterior margin". Gross Description: Received fresh labeled "anterior margin". It consists of a soft yellow-. tan irregular fibrofatty tissue fragment measuring 0.5 x 0.5 x 0.3 cm. Entirely submitted in cassette 4A. *******
+
+--- Page 4 ---
+Source of Tissue: 5. Labeled #5, "medial lymph node dissection at apex' Gross Description: Received fresh labeled "medial lymph node dissection at apex". It consists of a soft yellow-tan irregular fibrofatty tissue fragment measuring 3 x 2.5 x 0.5 cm. The specimen is sectioned to show a soft yellow-tan fibrofatty cut surface with no masses present. No obvious palpable lymph nodes present. Entirely submitted in cassettes 5A-5B. Source of Tissue: 6. Labeled #6, "retroperitoneal lymph nodes' Gross Description: Received fresh labeled "retroperitoneal lymph nodes". It consists of two soft yellow-tan irregular fibrofatty tissue fragments measuring 4 x 3 x 0.5 cm in aggregate. The specimen is sectioned to reveal a homogeneous, soft yellow-tan fibrofatty cut surface with no palpable lymph nodes present. Entirely submitted in cassettes 6A-6B. ************************************** Source of Tissue: 7. Labeled #7, "left ureter, stitch marks distal end" Gross Description: Received fresh labeled "left ureter, stitch marks distal end". It. consists of a soft tan-pink tubular tissue measuring 10.5 cm in length and 0.5 cm in diameter. The outer surface is inked black. The specimen is serially sectioned to show a smooth tan-pink cut surface with no obvious papillary structures noted. Representative sections are submitted in 7A-7E. Designation of Sections: 7A- distal resection margin, 7B- proximal resection margin, 7C-7E- random sections taken every 5 cm from distal to proximal ************************************************************************ Source of Tissue: 8. Labeled #8, "left kidney, stitch marks area of gross tumor protruding outside of kidney" Gross Description: Received fresh labeled "left kidney, stitch marks area of gross tumor protruding outside of kidney". It consists of a kidney with surrounding perinephric fat weighing a total of 290 grams and measuring 13.5 x 9.5 x 5.5 cm. The orientation suture is identified. The attached ureter measures 9.5 cm in. length and 0.5 cm in diameter. The ureter is opened to reveal a smooth tan-pink mucosal lining with no ulcerations or polyps present. The kidney is bisected to show a 6.7 x 5.5 x 5 cm ill-defined fleshy papillary tumor located predominantly at the superior and mid pole aspect of the specimen. The sutured area and surrounding fat margin closest to tumor are inked green. The ureteropelvic junction appears unremarkable. The anterior pole  and approximately 60% of the renal pelvis also appears unremarkable. The tumor comes within less than 0.1 cm of the closest capsule. Tissue submitted to tumor bank and representative sections are submitted in
+
+--- Page 5 ---
+Designation of Sections: 8A- urethral and vascular margins, 8B- additional. random section of ureter, 8C- ureteropelvic junction, 8D-8E- protruding section of tumor through outside of kidney, 8F-8H- tumor with closest. surrounding capsule, 8I-8J- tumor with adjacent uninvolved renal pelvis Procedures/Addenda AddendumDate Ordered: Status Date Complete. By: Date Reported Addendum Diagnosis Because of patient' s history of thyroid cancer, at the request of , the renal lesion was stained with antibodies TTF-1, thyroglobulin and pan keratin. Positive and negative control slides are satisfactory. Tumor is positive for keratin and negative for TTF-1 and thyroglobulin. The diagnosis of kidney cancer is unchanged. These tests were developed and their performance characteristics. determined by the immunohistochemistry laboratory at tht These tests have not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or. approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1998 (CLIA) as qualified to perform high complexity clinical. testing.
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diff --git a/output/text/5a272ab9-f035-4de2-a9aa-5b94ea95b80b.txt b/output/text/5a272ab9-f035-4de2-a9aa-5b94ea95b80b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..03b7482ceb810263c2eb5f011d17d99652f02a02
--- /dev/null
+++ b/output/text/5a272ab9-f035-4de2-a9aa-5b94ea95b80b.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+www7.ww.w9 UUID:EAB9E75C-2795-4D83-9806-5019DC14256E TCGA-C8-A273-01A-PR Redacted IrB APPROVED Multi-media systems, Inc. Form Revised / Clinical Case Report 1cs-0-3 (For Collection of Cancerous Tissue) s arcnome, infiltpot7y duct,Nos 8500f3 Criteria Srx:Breust,nos cso.q rimary Tun Informed Consent I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the - RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the. consent form as a free and voluntary act. A copy of this informed consent document will be retained at. our institution. Name of Physician or Study Coordinator. Signature Date Clinical Information ASNRSGENERALINFORMATIONT Date of Birth (mm/dd/yyy). Height Marital Status Race Temperature Single Married Gender Welght  Divorced  Widow  Blood Pressure Heart Rate  Male 'Female 97Vm  HISTORYOF PRESENTILLNESS Chief Complaints: (heirinnt: hreat Symptoms: the Lilt herfsnfutag Clinical Findings: Yhr Ligh+ hLeaH l wner guurant 3*9 c Axillr Performance Scale (Karnofsky Score):  100 Asymptomatic  80-90 Symptomatic but Fully Ambulatory  60-70 Symptomatic, in bed less than 50% of day.  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden. _ 20-30 Bed Ridden TRCURRENTMEDICATIONS. Drug. Dose Route Frequency Date (mm/dd/yyy) To N To To To / To
+
+--- Page 2 ---
+: :  PAST MEDICAL HISTORY ....  Diagnosis Date Treatment Status Diagnosis/Disease/Disorder/Injury w.w.. OBGYNHISTORY  # of Pregnancies Date of Fir~+ Menses Menopausal Status yovs-e Pre-menopausal # of Live Births Date of Last Menses  Peri-Menopausal  Post-menopausal NA  Hormone Replacement  Oral Contraceptive  iUD Birth Control:  Condom Therapy:  Other: : AASOGIALHISTORYS Environmental Hazards: Occupation: Smoking History Duration When Quit Type  Packs/day Current Status (yrs) (vr) yES UNO Alcohol Consumption Duration When Quit TYPE  Drinks/day Current Status (yrs) (yr) YES NO Drug Use Duratlon  When Quit TypE Frequency Current Status (yrs) () yeS DNO STEFAMILYMEDICAL HISTORY Age of Diagnosis  Diagnosis  Relative Cur ( LABDATA Date Test  Result Date 1  Result Test CEA   Negative  Positive: Negative  Positive: ...1 HIV   Negative  Positive: CA 15-3 Hep B Negative  Positive:  Positive: CA 19-9   Negative Hep C   Negative  Positive:   Negative  Positive: PSA   Negative  Positive: AFP Other:  Negative  Positive: Other:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+ DIAGNOSTIC STUDIES Results Date Study Ultrasound X-Ray cT Endoscopy MRI  Biopsy AECEINICALDIAGNOSIS::  Preoperative Clinical Diagnosis Crnce Location of Suspected Distant Metastasis. Location of Suspected Involved Lymph Nodes. Axill N : Date of Diagnosis Clinical Staging. T g M : Stage: Treatment Information AKCENSSURGIGALTREATMENTESWASC!. Date of Procedure. Procedure  Primary rumor Detailed Location Size Organ x cm 18ost Lneam Extension of Tumor. Lymph Nodes # of Lymph Nodes Description Location of Lymph Nodes. Axilln Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis. Detailed Locationd Size Organ M Surgical Staging T2 NA Stage: 11 NEOADJUVENTHERAPY (Chemo, Radiation, ImmunoHormonal or Molecular) Date (mm/dd/yyy) Dose Route Frequency Drug/Treatment / To To 1 / To To To 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by: 1 Date: I Time: Preserved by:  r SPEEIMENTYPE # of samples provided)  H..... . Frozen Paraffin Block  Blood/Serum/Plasma Slide Diseased Normal Diseased Normal Dtseased Normal Diseased Normal Time to LN2 Time to Formalin Tjme to LN2 T. As. min min min . PATHOLOGICALDESCRIPTIONS Primary Tumor Size Extension of Tumor Distance to NAT Qrgan 25x N cm cm Lymph Nodes # Examined # Metastasized Location Aill 2 Distant Metastasis  Organ Detailed Location Size Pathological Staging N1 M z Stage: TC  pT9 Notes: 4
+
+--- Page 5 ---
+COnsOLIdatED DIagnOstIC pAthOLOgy fORm* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION Diffuse STRUCTURAL PATTERN Mosaic I Streaming Necrosis x Storiform Lymphocytic Infiltration x Fibrosis Vascular Invasion Palisading KCysic Degeneration Clusterized Alveoia Formation Bleeding. Myxoid Change Indian File XPsammoma/Calcification 2. Cellular features: Sqwamous. + Adenomatous  Squamoid Cell Sarco ma tous Glandular cel! Lym phomatoes Spindie Cell Round Cell _Cell Stratification Lare Cell 7 Fibroblast Keratin Small Cell  Secretion M Osteoblast Desmosome RS CelVRS Like Intracyt. Vacuole Lipoblast  Pear! Inflam. Cell  Gland formation W Myoblast Plasma Celi Otherwise Specified: D,7s Z Dg 77 ibecxh 2.Cellular Differentiation: Well Moderately Poor S Nuclear Atypia: Nuckear Appearanst Aniso Nucleosis Hyperchromatism Nucleolar Prominent Multinocleated Giant Cell Mitotic Activity Nuckar Grade Histological Diagnosis: Edhlte/taj Astta Canna s G-1 M : Caaeinoou metgttotszed to CN. Comments: Date Director, Researcli Panoiogy PATHOLOGIST STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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diff --git a/output/text/5a279bdc-23fc-42fb-a83e-cf6a2369a39d.txt b/output/text/5a279bdc-23fc-42fb-a83e-cf6a2369a39d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..68e7ee4c1a8296263d9f0b338b69b9d5d2d912c3
--- /dev/null
+++ b/output/text/5a279bdc-23fc-42fb-a83e-cf6a2369a39d.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+1c s- 0 -3 8130/3 Carcrioma, ursthelial PATIENT HISTORY: Site : staldu, anterior wrll Cu1.3 -year-old-man with detrusor muscle-invasive, high-grade urothelial carcinoma. w y/I/M prostatic involvement.  with bladder base and possible PRE-OP DIAGNOSIS: Bladder cancer. POST-OP DIAGNOSIS: Not given. PROCEDURE: Radical cystoprostatectomy with construction of orthotopic neobladder. FINAL DIAGNOSIS: Part 1: Lymph nodes, Right pelvic, excision - THreE BEnigN LymPH NODeS (0/3). NEGATIVE fOR mALiGnAnCy (0/3). Collection Date: Part 2: Lymph nodes, Left peLvic, excision -- TWO 8eniGn Lymph nODes (0/2). negATive fOr maliGnancy (0/2). * paRt 3: RIght UReteR, mArgIn, SHaVe BIOpSy - SEGMENT OF BENIGN URETER. UUID:6DCDDE73-580E-46FF-9A06-39A85EB4830A A B.  NEgaTive for neopLASiA. TCGA-BT-A20T-01A-PR Redacted Part 4: Left ureter, margin, Shave Biopsy - Segment of benign ureter. B.  NEgaTivE fOr NeopLASiA. Part 5: Urinary BLADDeR, DiStal UretErS, BIlATerAl UreterS, PrOstaTE, BILATerAl SemInal VeSiCLeS, And vas DeferenTia, Radical Cystoprostatectomy -- URInARy BLADDER AND DISTaL URETERS: A.  ULCERATED, InVASIVE UrOTheLiAL CArcinOmA, hIgH-GRADE (2004 WhO/ ISUp), PRESENt ON THE  RIGht AnTeRIOr WALL OF THe URInARy BLADDER. CARCiNOMA INFiLTRATES THrOUGh THE  MUSCULARIS PROPRiA WITH EXTENSION (GROSSLY EVIDENT) InTO THE PERIVESICAL ADIPOSE TiSSUE. B.  MAximAL TumOr DiameteR iS 2.1 CM. C.  RARE PERINEURAL INVASION IS PRESENT (SLIDE 5AA). D.  PRESUmED CARCiNOmATOUS AnGIOLympHATiC iNVASiON iS PReSeNT, BUT nOt IOEnTIFieD HISTOLOGICALLY (SEE DIAGNOSIS F). E. mUTIfOcAL, EXTenSIVE, fLAt UROtheLIAl CARCinOmA In-SItU iS PRESENT WIThIn The URinARY BLAdDer anD prostatic urethra.  MICrOSCOPIC fOCUS OF mETASTATIC uROThELIAL CARCInOmA IS PRESENT IN ONE PERIVESICAL Lymph nODe (1/1) (SLIDE 5Z). ThE mETAStATiC FOCUS MEASuRES 0.2 Cm AnD IS COnFineD tO THE Lymph nODE, wITH nO EXTRACApSULAR EXTenSION IDenTiFIeD. G. TNm PAThOLOgIC STAge (UROtheLiAL CArcinOmA): T3b, N1, mX. H. HIStOLOgIC grADE: g3 (SEE SyNOPTIC). PrOSTATE, BILATERAL SEMiNAL VESICLES, AnD DIStAL VASA DEfErnTIA: PROSTATIC ADENOCARCINOMA. ACINAR TYPE, GLEASON SCORE 3 + 4 = 7 (SLiDES 5P, 5Q, 5DD, 5FF, 4t 5JJ). GLeAsOn PATTern 4 COmpOnent COmprISEs ApprOximAteLy 40% Of tHE PrOstaTE CARCINOMA VOLUME (SLIDES 5P, 5Q). Prostatic carcinoma is present, Limited to the Right Lobe Of the prostate gLanD. C.  GrEATEST nODULAR DIAmETER OF THE PROSTATIC ADENOCARCiNOmA IS 0.6 Cm, INVOLVING LESS ThAn 5% Of the SAmpled PROState gLAnD vOLumE. D.  PROStATE CARCInOmA IS COnFIneD TO The PROSTATE GLAnD, WIThOUt eXTraCApSULAR ExTenSiOn nOr invOlVement Of the UrinARy BLadDer. E.  BILATERAL SEMINAL VESICLES AND DISTAL VASA DEFERENTIA ARE FREE OF NEOPLASIA. FOCAL PERINEURAL INVASION BY PROSTATIC ADENOCARCINOMA IS IDENTIFIED (SLIDE 5Q) F G.  NO ANGIOLYMPHATIC INVASION IS IDENTIFIED. H.  MULT!FOCAL HIGH-GRADE PROSTATIC inTRAEPITHELIAL NEOPLASIA (HGPiN) iS PRESEnT. iNTraDuctaL UROtheLiaL CARcinomA IS PREseNt in The PrOstaTe in PEriUretHral DuctS iN COntinuity with Urethral fLAt urotheLiAL CaRcinoma in-Situ (SLiDes 5B, 5C, 5DD, 5gg). TNm PathOlOgic Stage (PrOstaTic ADenOcArcinomA): T2a, n0, mX. 1. K.  HISTOLOGIC GRADE: G3-4 (SEE SYNOPTIC).
+
+--- Page 2 ---
+Synoptic Data - PRimary urinary BLaDDer TumOrSe SPecimen type: Radicai cystoprostatectomy TUMOR SITE: (Anterior wall TUMOR SIZE: Greatest dimension: 2.1 cm Additional dimensions: 1.5 X 1.2 cm HIstoLOgiC Type: Urothelial (transitional cell) carcinoma ASSOCIATED EPITHELIAL LESIONS: None identified HISTOLOgIC GRADE: Urothelial carcinoma - High-grade TUmOR CONFIGURATION: Ulcerated PATHOLOgIC STAGIng (pTnm): pT39 pN1 Number of nodes examined: 6 Number of nodes involved: 1 pMX  MARGINS:  Margins uninvolved by invasive carcinoma VENOUS/LYMPHATIC (LARGE/SMALL) VESSEL INVASION (V/L): Present DiReCt eXTensIOn Of invasIve TumoR: Perivesical fat ADDITIONal PAThOLOgIC FIndings:  Urothelial dysplasia (low-grade intraurothelial neoplasia) SynOpTIc DATA - PRimARy PROStaTe TUmORS INvasive CA iDentifIeD?: Yes TUMOR hISTOLOGY: Adenocarcinoma NOS Primary gleason grade: 3 SeCOndary GLeAsOn GRAdE: 4 GLEASON SUm SCORE: 7 GLEASON 4/5 PERCENTAGE: 40% Weight of prostate: 30gm TUMOR SIZE: Maximum dimension: 0.6 cm Lobe Laterality:  Right Lobe PeRCENt Of SPECImeN INVOLVed by TUmOR: < 5% of specimen invoived by invasive tumor MULTIFOCAL DISEASE: No HIGH GRADE PIN: Yes - multifocal ExTrApROsTaTIC exTensiOn: No  PERINEURAL INVASION: Yes ANGIOLYMPHATIC INVASION: No  SEMINAL VESICLE INVASION: No SURGICAL MARGIN INVOLVEMENT: All surgical margins frse of tumor LymPh nODeS EXAmINED: Lymph noDes positive: 6 0 t stage, pathologic: pT2a N stage, pathologic: pNX m stage, pathologic: pMX HISTOLOGIC GRADE: G2, Moderately differentiated
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diff --git a/output/text/5a357b20-0620-435f-9ec1-97a49601282a.txt b/output/text/5a357b20-0620-435f-9ec1-97a49601282a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f09a8f286da820595b5376a321a7d20ec8adb5b6
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+
+--- Page 1 ---
+ICD o-3 Ca cinsno, Isludor irfuststirey D 8520Yi JJ 4/2/) 3 UUID:4C3E3E5B-E24E-447B-A688-68D6EBE15A9F TCGA-AR-A50M-01A-PR Redacted Breast, left, wide local excision: Infiltrating lobular carcinoma, Nottingham grade II (of III) [tubules 3/3, nuclei 2/3, mitoses 2/3; Nottingham score 7/9], forming a mass (4.7 x 2.2 x 1.5 cm) [AJCC pT2]. Lobular carcinoma in situ is present. Biopsy site changes are present. Angiolymphatic invasion is not identified. Calcifications are identified in benign ducts. All surgical resection margins, after re-excision of the superomedial margin, are negative for tumor (minimum tumor free margin, 0.8 cm, deep margin). Multiple (4) left breast intramammary Iymph nodes are negative for tumor. Breast, left "palpable" nodule, excision: A single left breast intramammary lymph node is negative for tumor. Lymph node, left intramammary sentinel, excision: A single left intramammary sentinel lymph node is positive for isolated tumor cells [AJCC pN0 (i+) (sn)]. These isolated tumor cells are seen on cytokeratin immunostaining only. Blue dye is identified. Lymph nodes, left axillary sentinel, No. 1 and No. 2, biopsy: Multiple (3) left axillary sentinel lymph nodes are negative for metastatic carcinoma [AJCC pN0 (i-) (sn)]. Blue dye is not identified in any of the three left axillary sentinel lymph nodes. Immunohistochemical cytokeratin stain was performed on the paraffin embedded sentinel lymph node tissue and confirms the H&E impression. Breast, right, wide local excision: Infiltrating ductal carcinoma, Nottingham grade II (of III) [tubules 3/3, nuclei 2/3, mitoses 2/3; Nottingham score 7/9], forming a mass (1.4 x 1.0 x 0.9 cm) [AJCC pT1c]. Extensive ductal carcinoma in situ, low to intermediate nuclear grade, present within (greater than 25%) and outside the invasive component (over an area 1.8 x 0.5 x 0.3 cm) which extends anteriorly from the invasive tumor. Angiolymphatic invasion is present. Biopsy site changes are present. All surgical resection margins, after re-excision of the anterior/medial margin, are negative for tumor (minimum tumor free margin, 0.9 cm, deep margin). A radioactive seed is identified. Lymph nodes, right axillary, dissection: Multiple (4 of 25) right axillary lymph nodes are positive for metastatic breast carcinoma [AJCC pN2]. The largest metastatic focus is a collection of matted lymph nodes that measure 3.0 x 1.9 x 1.6 cm. Faxitron done. Case seen in consultation with Rj husst
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diff --git a/output/text/5a4fc48b-503b-4b38-905d-1a4d5d6fcc85.txt b/output/text/5a4fc48b-503b-4b38-905d-1a4d5d6fcc85.txt
new file mode 100644
index 0000000000000000000000000000000000000000..324c5fc4853da197232dfc832fd691103e88e286
--- /dev/null
+++ b/output/text/5a4fc48b-503b-4b38-905d-1a4d5d6fcc85.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+Clinical Diagnosis & History: Left breast inc, DcIs, approximately 1.5 cm BRcA2 (+). presents for bilateral Tm, left sentinel lymph node biopsy. Specimens Submitted:  SP: Sentinel node #1, level 1, left axilla (fs) UUID:63E34973-F630-4295-AC1B-94F818BEBE41 TCGA-A0-A03V-01A-PR 2: SP: Sentinel node #2, level 1, left axilla (fs) Redacted 3: SP: Left breast 4: SP: Right breast DIAGNOSIS: 1) LYMPH NODE, SENTINEL #1 LEVEL I LEFT AXILLA; BXCISION: - ONE BENIGN LYMPH NODE (O/1) - DEEPER LEVELS RECUTS AND SPECIAL STAINS HAVE BEEN ORDERED. WILL BE REPORTED IN AN ADDENDUM. THE RESULTS 2) LYMPH NODE, SENTINEL #2 LEVEL 1 LEFT AXILLA; EXCISION: - ONE BENIGN LYMPH NODE (O/1). - DEEPER LEVELS RECUTS AND SPECIAL STAINS HAVE BEEN ORDERED. WILL BE REPORTED IN AN ADDENDUM.S THE RESULTS 3) BREAST, LEFT; MASTECTOMY: - INVASIVE DUCTAL CARCINOMA, NOS TYPE, HISTOLOGIC GRADE III/III (SLIGHT OR NO TUBULE FORMATION), NUCLEAR GRADE II/III (MODERATE VARIATION IN SIZE AND SHAPE), MEASURING 1.5 CM IN LARGEST DIMENSION MICROSCOPICALLY. - DUCTAL CARCINOMA IN SITU (DCIS) IS ALSO IDENTIFIED, SOLID TYPE, WITH INTERMEDIATE NUCLEAR GRADE.S - THE DCIS CONSTITUTES LESS THAN OR EQUAL TO 25% OF THE TOTAL TUMOR MASS, AND IS PRESENT ADMIXED WITH THE INVASIVE COMPONENT. - THE INVASIVE CARCINOMA IS LOCATED IN THE UPPER INNER QUADRANT. THE DCIS IS LOCATED IN THE UPPER INNER QUADRANT. - NO INVOLVEMENT OF THE NIPPLE BY EITHER IN SITU OR INVASIVE CARCINOMA IS IDENTIFIED. - NO CALCIFICATIONS ARE IDENTIFIED IN BITHER THE INVASIVE OR IN SITU COMPONENT. - NO VASCULAR INVASION IS NOTED. - NO INVOLVEMENT OF THE SURGICAL MARGINS BY EITHER INVASIVE OR IN SITU CARCINOMA IS IDENTIFIED. - NO SKIN INVOLVEMENT BY CARCINOMA IS IDENTIFIED. ** Continued on next page ** Ics-0-3 c arciioma, infiItratnj cuct, vcs 85ov/3 Sit : hrast, nos C5v.9 10/2sJ11
+
+--- Page 2 ---
+Page 2 of THE NON-NEOPLASTIC BREAST TISSUE IS UNREMARKABLE RESULTS OF SPECIAL STAINS (ER, PR, HER2-NEU) WILL BE REPORTED AS AN ADDENDUM. 4) BREAST, RIGHT; MASTECTOMY:S - BENIGN BREAST TISSUE WITH FIBROCYSTIC CHANGES INCLUDING DUCTAL HYPERPLASIA WITHOUT ATYPIA AND APOCRINE METAPLASIA. - UNREMARKABLE NIPPLE AND SKIN. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. *** Report Blectronically Signed Out *** Gross Description: 1. The specimen is received fresh for frozen section consultation labeled "sentinel node number one, level 1, left axilla" and consists of a single submitted for frozen section consultation. Summary of sections: rsc-frozen section control 2).  The specimen is received fresh for frozen section consultation labeled "sentinel node number two, level 1, left axilla" and consists of a single lymph node measuring 0.8 x 0.5 x 0.5 cm, which is entirely submitted for frozen section consultation. Summary of sections:. FSC-frozen section control 3).  The specimen is received fresh labeled, "left breast, stitch marks axillary tail, ink margins" and consists of a breast measuring 17.5 x 6.5 x 4.5 cm with overlying skin ellipse measuring 1.5 x 1.4 x 1.1 cm.  Situated centrally on the skin surface is an everted nipple measuring 2.2 x 2.0 x 1.0 cm and areola measuring 3.5 x 2.5 cm. The skin is grossly unremarkable. suture demarcates the axillary aspect. The posterior surface of the breast A is inked black and the specimen is serially sectioned to reveal a firm from the deep margin, in the upper inner quadrant.  No additional lesions are identified. Tissue is given to Tps..  Sectioning of the axillary aspect Continued on next page **
+
+--- Page 3 ---
+Page 3 of 6 Representative sections are submitted. Summary of sections: N - nipple NB . nipple base. skin deep margin. tumor UIQ upper inner quadrant LIQ lower inner quadrant UOQ  - upper outer quadrant LOQ - lower outer quadrant 4.  The specimen is received fresh labeled, "right breast, stitch marks axillary tail, ink margins" and consists of a breast measuring 18.0 x 15.5 x. 4.2 cm with overlying skin ellipse measuring 14.2 x 5.2 cm.. centrally on the skin surface is an everted nipple measuring 2.0 x 2.0 x 0.7.  Situated cm and areola measuring 4.5 x 3.2 cm.  The skin is grossly unremarkable. A is inked black and the specimen is serially sectioned to reveal predominant. fatty breast tissue with streaks of fibrous tissue.  No masses or lesions are identified.  Sectioning of the axillary aapect reveals no grossly. identifiable lymph nodes.  Representative sections are submitted. Summary of sections: N - nipple NB - nipple base S - skin inner quadrant LIQ - lower inner quadrant UOQ - upper outer quadrant LOQ  lower outer  quadrant Summary of Sections: Part 1: SP: Sentinel node #1, level 1, left axilla (fs) Block Sect. Site PCs 1 fsc 1 Part 2: SP: Sentinel node #2, level 1, left axilla (fs) Block Sect. Site pCs 1 fsc 1 ** Continued on next page
+
+--- Page 4 ---
+Part 3: SP: Left breast Block Sect. Site PCs 1 D 2 LIQ 2 LOQ 1 N 1 1 NB 1 s 1 T UIQ 2 UOQ Part 4: SP: Right breast Block Sect. Site pCs 2 2 LIQ LOQ 1 N 12 NB s 22 UIQ UOQ Procedures/Addenda: Addendum Date Ordered: Status: Signed Out Date Complete: By: Date Reported: Addendum Diagnosis ADDENDUM 3). BREAST, LEFT; MASTECTOMY: Immunohistochemical stains were performed on formalin-fixed tissue with the following results for invasive carcinoma (block T4):. ESTROGEN RECEPTOR (6F11, >95% nuclear staining with moderate to strong intensity PROGESTERONE RECEPTOR (1E2; >80% nuclear staining with wo.. srate to strong intensity HER2 (HercepTest; Negative (0) (0% of invasive tumor cells exhibit complete membranous staining;. Uniformity of staining: absent; Homogeneous, dark circumferential pattern:  absent) ** Continued on next page **.
+
+--- Page 5 ---
+ satisfactory Comment: HercepTesttm : HER2 protein overexpression in breast cancer tissue routinely processed for histological evaluation. The Her2 test results are reported in accordance with the Asco/cAp guideline recommendations for Her2 testing in breast cancer (J Clin Oncol 2007; 25(l):118-145). Addendum Date Ordered:. Status: Signed Out Date Complete: By: Date Reported:. Addendum Diagnosis ADDENDUM 1) LYMPH NODE, SENTINEL #1, LEVEL 1, LEFT AXILLA; EXCISION: 2) LYMPH NODE, SENTINEL #2, LEVEL 1, LEFT AXILLA; EXCISION:  ADDITIONAL H&E STAINED SECTIONS AND IMMUNOHISTOCHEMICAL STAINS FOR CYTOKERATINS (AE1:AE3) SHOW NO EVIDENCE OF METASTATIC TUMOR. m.D. Intraoperative Consultation: Note:  The diagnoses given in this section pertain only to the tissue sample. examined at the time of the intraoperative consultation.. 1) FROzRN srcTIon DiagNOsIs: SP: SENTINEL NODE #1, LEVEL 1, LEFT AXILLA (FS) : LYMPH NODE, NEGATIVE FOR TUMOR PERMANENT DIAGNOSIS: SAME 2) FROZP CPCTION DIAGNOSIS: SP: SENTINEL NODE #2, LEVEL 1, LEFT AXILLA (FS) : LYMPH NODE, NEGATIVE FOR TUMOR PERMANENT DIAGNOSIS: SAME Continued on next page.
+
+--- Page 6 ---
+5of Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS: LEFT AXILLA (FS) SP: SENTINEL NODE #1, LEVEL 1, :LYMPH NODE, NEGATIVE FOR TUMOR PERMANENT DIAGNUSIS: SAME 2)  FROZEN SRCTION DIAGNOSIS: SP: SENTINEL NODE #2, LEVEL 1. LEFT AXILLA (FS) LYMPH NODE, NEGATIVE FOR TUMOR PERMANENT DIAGNOSIS: SAME ** End of Report
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diff --git a/output/text/5a6d7bb8-c843-4f8f-99e5-2051b52291d4.txt b/output/text/5a6d7bb8-c843-4f8f-99e5-2051b52291d4.txt
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index 0000000000000000000000000000000000000000..cec875e1710db7a1170965db6795d562245d61f6
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+Ics-0-3 Cmcinoma,nfjiItruHng duct, nos 85o0f3 Site: brast, NOS c 50.9 OC#: Tss #. Procurement Date:3/1/2011 Laterality:Left, upper outer quadrant Path Report:BREAST TISSUE CHECKLIST Specimen type: Lumpectomy Specimen size: Not specified Tumor site: Upper outer quadrant Tumor size: 2 x 0 x 2.2 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinoma. Histologic grade: Moderately differentiated. Tumor extent: Not specified Lymph nodes: 3/10 positive for metastasis (Axillary 3/10) Extracapsular invasion of the lymph nodes: Not specified Margins: Uninvolved Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified. Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified. Comments: None UUID:5F2A52E5-2844-4242-8CE4-A87DF9D9C97B 'Redacted TCGA-E9-A245-01A-PR 4/21
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diff --git a/output/text/5a7e92c7-c957-4eaf-b02f-ff0463fe3f38.txt b/output/text/5a7e92c7-c957-4eaf-b02f-ff0463fe3f38.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a82da0b537e4c80a9a464be3003b0734e82c4702
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+--- Page 1 ---
+UUID: B9C848FD-453C-4A56-B625-C4C680790D6A TCGA-OR-ASKO-01A-PR Redacted Procedure: L adrenalectomy Gross description: 7.2 x 6 x 4.8cm, tumor 5.8cm Diagnosis: adrenocortical carcinoma, 5 per 10 hpf, Kl67 20%, focally 30-40% Reference Pathology: Diagnosis: adrenocortical carcinoma, Kl67 30% IcD-o-3 Weiss score: 9. arc inomo, adrenal cortcal Hough score: 4.89. 8370/3 Van Slooten score: 22.7 Site; Adreral Cland,cortex CJi D Jtj x)o|13
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diff --git a/output/text/5a80cd40-648c-4d49-9362-3da718b37e18.txt b/output/text/5a80cd40-648c-4d49-9362-3da718b37e18.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0a05d1d810b88eeee04fe2ad7c117af5d238903b
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+--- Page 1 ---
+CS-0-3 C ascni omn n fniH^tg duct Nes 83oof3 Site: buut, Nos c50.9 h Ff8/ PATIENT HISTORY: Prcedure Date: DATE OF LMP: DATE OF LAST DELIVERY: PRE-OP DIAGNOSIS: R BREAST CANCER POST-OP DIAGNOSIS: SAME OPERATIVE+PROCEDURE! R'SEGM MAST; AXILLARY DISS .. CLINICAL HISTORY:S MATERIAL SUEMITTED: A) RIGHT SEGMENTAL MASTECTOMY, PROCUREMENT BY SURGICAL PROCEDURES B) RIGHT AXILLA, FROCUREMENT BY SURGICAL PROCEDURE INTRAOPERATIVE CONSULTATION: FRozen secticn: Riqht brcast mass, 7.1 by ?.1 by 2.0 cm, 0.4 cm from the closest posterior margin. FS Diagnosis: Infiltratinq ductal carcinoma. ER/pR taken. Ccnsult: Riyht axillary lynph node dissection. Metastatic tumor in multiple matted Jymph nodes.. FINAL DIAGNOSIS: FINAL DIAGNOSIS: A) RIGHT BREAST SEGMENTAL MASTECTOMY: INFILTRATING DUCTAL CARCINOMA (2.1 CM), WITH IXTENSIVE LYQHATIC PERSATION AND CANCERIZATION OF THE DUCTS. NUCLEAR GRADS FOOR, HISTOLOGIC CRADE 3S ALL SURGICAL RESECTION MARGINS FREE OF TUMOR B) RIGHT AXILLA DISSECTION: SOME WITH EXTRACAPSULAR SPREAD PATHOLOCIC STAGING: T2 N2 MX UUID:3EBBE51B-6D17-4A77-AAE1-E0424CEA56DB TcGA-bH-A203-01A-PR Redacted Nag
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diff --git a/output/text/5a8387b8-c532-4581-a7fb-cbeac66e7027.txt b/output/text/5a8387b8-c532-4581-a7fb-cbeac66e7027.txt
new file mode 100644
index 0000000000000000000000000000000000000000..33ad9ca303b4378f5acf2aa56129d0821bb3c99c
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+
+--- Page 1 ---
+UUID:EAADA209-BED3-4FA3-B39C-2428BF278EF7 TCGA-VD-AA8P-01A-PR Redacted Department of Pathology HISTOPATHOLOGY  Surname Lab No Clinical Consultant & Location Forename(s)  DOB/Age Sex Unit No Request Date This Copy For:. SPECIMEN RIGHT GLOBE ENUCLEATION, PROGNOSTIC AND DIAGNOSTIC CLINICAL DETAILS See diagram. Measurements 10.63 x 10.18 x (10.37)mm MACROSCOPIC DESCRIPTION A fresh, intact, right globe. Dimensions: Axial 25mm, Horizontal 23.Smm, Vertical 24mm Cornea: Horizontal 12.5mm, Vertical 12mm Optic nerve: flesh On trans-illumination, a shadow is seen in the inferolateral position, approx 13mm. Plane of section: vertical Intraocular description: A solitary dome shaped, pigmented choroidal mass is seen. Prominent vessels arising from optic disc. IoL is present. Tumour size. LBD 12mm, Height 10.5mm MICROSCOPY Sections show a pigmented choroidal melanoma consisting predominantly of spindle cells. Tumour cells express Melan-A and HSp 27 (score 3). The number of mitosis is approximately 8/40 high power fields. The microvasculature of the melanoma is prominent, and closed loops are present in the planes of sections. The lymphocytic infiltrate within the tumour is minimal. Tumour necrosis is not seen. There is no tumour extension through the sclera, optic nerve or vortex veins examined. Tumour cells are not seen at the resection margins. IDO3 r'J s/3c/1y Reported: Pathologist: Electronically Verified: 
+
+--- Page 2 ---
+orinted: Department of Pathology Page 2 of 3 HISTOPATHOLOGY REPORT Tel: Surname Lab No Clinical Consultant & Location Forename(s) DOB/Age  Sex UnIt No Request Date Thls Copy For: Elsewhere, the cornea shows no significant abnormality. The anterior chamber angles are open and the anterior chamber is deep. The iris shows no significant abnormality but the ciliary body appears atrophic with hyalinisation of ciliary processes. Residual peripheral cataractuous lens is. identified. Retina overlying the tumour is slightly atrophic. DIAGNOSIS Right eye, enucleation: Choroidal melanoma of predominantly spindle' cell type. SUMMARY SPECIMEN 2= Eye TUMOUR PRESENT Yes TUMOUR TYPE 1= Melanoma CELL TYPE 2- Spindle B CT LOOPS 2- Closed loops NECROSIS No PIGMENTATION Yes LYMPHOCYTIC INFILTRATIONS  No MITOTIC FREQUENCY 8/40 HPF DIFFUSE MELANOMA No SPREAD 1= No CLEARANCE 2= Adequate HSP-27 POSITIVITY 3= >70% LARGE DIAMETER 12 mm THICKNESS 10.5 mm COMMENT Molecular genetic examination of DNA extracted from the tumour cells will be performed using multiplex-ligation Reported: Pathologist: Electronically Verified: 
+
+--- Page 3 ---
+rinted Department of Pathology Page 3 of 3 HISTOPATHOLOGY REPORT Tel: Surname Lab No Clinical Consultant & Location Forenarne(s) DOB/Age Sex Unit No Request Date Thls Copy For: dependent probe amplification (mLpa), looking at chromosomes 1, 3, 6 and 8. A supplementary report will follow in due course. SUPPLEMENTARY REPORT - MLPA In the meantime, molecular genetic analysis of tumour DNA extracted from the fresh uveal melanoma tissue was performed. using the technique termed multiplex ligation-dependent probe amplification (MLpA). These investigations were performed in the The kit P027 from , which examines for gains or. losses in 31 loci on chromosomes 1, 3, 6 and 8, was used.  and the quality assessed using multiplex-pcR prior to the MLPA The DnA concentration was high and of good quality on assessment. The MLpA reaction was run at least twice on differing occasions, resulting in similar results. The results of the sequence analysis of the MLpA products is printed on a separate report. In summary, sequence analysis demonstrated: loss of chromosome 1p, monosomy 3, normal chromosome 6 and gains in chromosome 8.. Taken together. these molecular data would place the patient in the high risk group with respect to the development of metastatic melanoma. Consideration of clinical features of the tumour is,. however, also required. Reported: Pathologist: Electronically Verified: nary Tumor Site Prior Malig
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diff --git a/output/text/5aae254f-83f0-4128-829d-f797ee052254.txt b/output/text/5aae254f-83f0-4128-829d-f797ee052254.txt
new file mode 100644
index 0000000000000000000000000000000000000000..413ac90b436c9a9b87626867262b7918b83960f2
--- /dev/null
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+
+--- Page 1 ---
+tnqiltnatin, duct cainem,0v5 35/3 Sita Jrunst,N4 122110 C50.9 page 1 / 1 Department of Cancer Pathologye copy No. Date: Examination: Histopathological examination. Patient: Examination No.: PeseL: Age: Gender: F Material: Multiple organ resection - left breast Unit in charge. Physician in charge: Material collected on Material received on Expected time of examination: up to 8 working days. Clinical diagnosis: Cancer of the left breast (inner lower quadrant).  Examination performed on: Macroscopic description: Left breast, sized 21.8 x 21.2 x 6.5 cm, removed along with axillary tissues sized 11 x 7 x 3 cm and a skin flap of 21.2 x 11.1 cm. Weight 1,360 g. Tumour sized 2.8 x 2.1 x 1.5 cm found on the boundary of inner quadrants,  placed 3.6 cm from the upper edge, 0.9 cm from the base and 2.8 cm from the skin. Status after core needle biopsy (test No Microscopic description: Carcinoma ductale invasivum NHG3 (3+3+3: 35 mitoses /10 HPF - visual area: 0.55mm). Focuses of carcinoma ductale in situ (Dcis) found within tumour (solid type, with high nuclear. atypia and comedo necrosis, 10% of the tumour). Reactio lymphocytaria peritumoralis. Lesions in situ: cancerisatio lobulorum. Mamilla sine laesionibus. UUID: F8C2F3EF-FA73-4FF8-9A4E-7F557E68D560 TCGA-D8-A143-01A-PR Glandular tissue showing parenchyma atrophy.e Redacted Axillary lymph nodes: Lymphonodulitis reactiva No XI. Histopathological diagnosis: (including test No. Carcinoma ductale invasivum et ductale in situ mammae sinistrae. (NHG3, pT2, pNO ). 1NvA$lVE Av 1N sITV NCTAL CARCNOHA OFT#E GT BkEy8T Compliance validated by:
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diff --git a/output/text/5acae1cb-722d-4e59-9554-f433a15805e8.txt b/output/text/5acae1cb-722d-4e59-9554-f433a15805e8.txt
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index 0000000000000000000000000000000000000000..1eac209fe8f6ee4af8ec25a70895cdadace07dd7
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+
+--- Page 1 ---
+1Cs-0- 3 Careiomn, vifiltnatwg duct, Nos 85of3 Site: susst, Nos. c 50.9 h 4f3H1 OC#: TSS #: Procurement Date:3/3/2011 Laterality;Left/ upper inner quadrant Path Report:BREAST TISSUE CHECKLIST Specimen type: Lumpectomy Specimen size: Not specified Tumor site: Upper inner quadrant Tumor size: 1.3 x 0 x 1.5 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinoma. Histologic grade: Moderately differentiated. Tumor extent: Not specified Lymph nodes: 0/10 positive for metastasis (Axillary 0/10) Extracapsular invasion of the lymph nodes: Not specified Margins: Uninvolved. Nottingham Histologic Score Tubule formation: Not specified Nuciear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined. Evidence of neo-adjuvant treatment: Not specified. Additional pathologic findings: Not specified Comments: None UUID:61E73960-3280-413E-AF1D-2EF458229383 Redacted
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diff --git a/output/text/5ae0dc0f-17be-4bcb-96b5-f7af80202fe8.txt b/output/text/5ae0dc0f-17be-4bcb-96b5-f7af80202fe8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ddc23935ae83856beb75ec7dc03eef54d7cfb27c
--- /dev/null
+++ b/output/text/5ae0dc0f-17be-4bcb-96b5-f7af80202fe8.txt
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+
+--- Page 1 ---
+UUID:2246A9D0-E968-4FC1-83D1-D048458003F90 Redacted TCGA-CF-A47W-01A-PR Clinical Case Report 1cs-0-3 (For Collartinn of Cancerous Tissue). c acun oma, Papillery t^ans`tinat cell 8130|3 Ste: blodd, Nos C67.9 jw q/3if12 aniorcu cyusent I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the. RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator. Clinical Information GENERAL INFORMATION Date of Birth (mm/dd/yyyy) Helght Marital Status  Race Temperature Lm 6 0)  Single Married EINAMES Gender Weight  Divorced  Widow  Blood Pressure Heart Rate Male  Female 6 O[ccs 12/6 s HISTORY OF PRESENT ILLNESS Chief Complaints: 4bdon{nal pcu`n j beooo inte wme Symptoms: weakne?s j weighf-Coss Clinical Findings: Performance Scale (Karnofsky Score):.  100 Asymptomatic 80-90 Symptomatic but Fully Ambulatory ^60-70 Symptomatic, in bed less than 50% of day  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden  20-30 Bed Ridden CURRENT MEDICATIONS Drug Dose Route Frequency Date (mm/dd/yyyy) To 1 To 1 To / To To
+
+--- Page 2 ---
+PAST MEDICAL HISTORY Diagnosis/Disease/Disorder/Injury Dlagnosis Date Treatment Status OB/GYN HISTORY Date of First Menses # of Pregnancies Menopausal Status  Pre-menopausal  Peri-Menopausal Date of Last Menses # of Live Births  Post-menopausal Birth Control:  Condom  Oral Contraceptive IUD  Hormone Replacementd Therapy:  Other: SOCIAL HISTORY Occupatlon: Environmental Hazards: Smoking History TYPE  Packs/day. Duration When Quit Current Status Ho Pasck Ida. 20 (ys) [stll smo(e  yr) YES NO Alcohol Consumption. TYPE Drinks/,day Duration When Quit Current Status YES_NO Ldn l ctcy yrs Drug Use Current Status TyPE Freguency Duration When Quit  YES NO (yrs) (ye) FAMILY MEDICAL HISTORY Relative Dlagnosis Age of Dlagnosis LAB DATA Result Date Test Result Date Test HIV  Positive: CEA  Negative  Positive: Negative Hep B  Negative  Positive: CA 15-3  Negative  Positive: Hep C  Negative  Positive: I CA 19-9  Negative  Positive: AFP   Negative  Positive: PSA  Negative  Positive: Other: Other: Negative  Positive:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+DIAGNOSTIC STUDIES Study Results Date Ultrasoundp A bopeuk Blodcle (.2. X-Ray CT Endoscopy MRI Biopsy CLINICAL DIAGNOSIS Preoperative Clinical Diagnosis Location of Suspected Involved Lymph Nodes. Location of Suspected Distant Metastasis. Clinical Staging Date of Dlagnosis T2 No MO Stage:I Treatment Information SURGICAL TREATMENT Procedure Date of Procedure Pesestion t. Blades 11  Primary Tumor  Organ Detailed Location Size Urinapff... hladeer lZx6 xZ cm Extension of Tumor Lymph Nodes Descriptlon Location of Lymph Nodes # of Lymph Nodes  Palpable, Non-Dissected Lymph Nodes. Dissected Lymph Nodes Distant Metastasis Organ  Detailed Location Size Surgical Staging T 2 No. Stage:T NEOADJUVENT THERAPY (Chemo, Radiation, Immuno, Hormonal, or Molecular) Drug/Treatment Dose Route Frequency Date (mm/dd/yyy) To To 1 1 / To 1 / To 1 1 / To 3
+
+--- Page 4 ---
+Pathology Forms Specimen Information Collected by: ... Date: Preserved by: -- Date: SPECIMEN TYPE (# of samples provided) Paraffin Block Blood/Serum/Plasma Slide Frozen Normal Diseased Normal Diseased Normal Diseased  Normal Diseased 2 4 2 4 2 Time to LN2 Time to Formalin Time to LN2 IA. min L2. min min PATHOLOGICAL DESCRIPTION Primary Tumord Organ Size Extenslon of Tumor Distance to NAT Z x 6 x 2cm 5 Uriraes blzder lmor cm Lymph Nodes Location # Examined # Metastasized Distant Metastasis Organ Detailed Location. Size Pathological Staging NO M o Stage: pT 2 Notes: 4
+
+--- Page 5 ---
+cOnsOlIdatEd DiagnostIc patholOgy form* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION STRUCTURAL PATTERN  Diffuse X Streaming Mosaic  Storiform Necrosis Fibrosis Lymphocytic Infiltration  Palisading Vascular Invasion XCystic Degeneration Clusterized X Bleeding Alveolar Formation Myxoid Change  Indian File Psammoma/Calcification 2. Cellular features: Squamous Adenomatous Sarcomatous Lymphomatous Squamoid Cell  Glandular cell Round Cell Large Cell Spindle Cell Cell Stratification Fibroblast Small Cell  Keratin Secretion Osteoblast  RS Cell/RS Like  Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell  Pearl  Gland formation  Myoblast Plasma Cell Otherwise Specified: b 7o7 br7s7 Dz8o7 Pu 7U Neelors 2. Cellular Differentiation: Well Moderately Poor Nuclear Atypia:  Nuclear Appearance Aniso Nucleosis Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity Nuclear Grade Histological Diagnosis: Hpsllsey Tasasi^lonal tell CaRemro,  Comments: Date *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND PATHOLOGIST STAFF FOR RESEARCH USE ONLY) Tumor Site Discrepancy
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diff --git a/output/text/5af0ff25-6380-4b79-8d88-1c159b39addc.txt b/output/text/5af0ff25-6380-4b79-8d88-1c159b39addc.txt
new file mode 100644
index 0000000000000000000000000000000000000000..713f57c1555dd1fd9be4855f3ba2229a8138872b
--- /dev/null
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+
+--- Page 1 ---
+FINAL DIAGNOSIS: Part 1: breast, Right, total mastectomy - A." MULTiFOCAL AND MULTiCENTRIC inFILTRATINg DUCTAL CARCInOMA (1B, 1D, 1E, 1F, 1G, 1H, 1m, 1N, 10 and 1T). B. THE TUmOR SIZES ARE AS FOLLOWS: 2.5 X 2 X 2.1 CM; 1.5 X 1.3 X 1 CM; 0.7 X 0.6 CM AND 0.6 X 0.5 CM (see comment). C.  NOTTINGHAM SCORE IS 6/9 (TUBULES 2, nUCLEI 2, MITOSES 2). D.  LYMPHOVASCULAR INVASION IS NOT APPRECIATED.S E. DUCTAL CARCINOmA IN SITU, CRIBRiFORm TYPE, NUCLEAR GRADE 2, REPRESENTING ABOUT LESS THAN 1% OF TUMOR VOLUmE. F. DUCTAL CARCINOMA IN SITU IS PRESENT ADMIXED WITH INVASIVE TUMOR. G. MARGINS OF RESECTION ARE FREE OF TUMOR. H.  Nipple, free of tumor. SKIN, NO TUMOR IS SEEN. J. CHANGES CONSISTENT WITH PREVIOUS CORE BiOPSY SITE, SEE PRIOR K. FIBROADENOMA AnD FIBROADENOMATOID NODULAR CHANGES. L. FIBROCYSTIC CHANGES WITH DUCT ECTASIA, DUCTAL EPITHELiAL HYPERPLASiA AND COLUMNAR CELL CHAnGeS. M. IMMUnOHISTOCHEMICAL STAINING FOR ESTROGEN RECEPTOR, PROGESTERONE RECEPTOR AND HER- 2/NEU WERE PREVIOUSLY PERFORMED ON ESTROgen REcEpTOR -- pOSITIVE, pROgESTErONe RECEpTOR - pOsITIVe, hER-2/neU - EquIVOCAL. WERE REPORTED AS FOLLOWS: (SCORE +2). HER-2/NEU BY FISH WAS NOT AMPLIFIED. PART 2: LYmPH NODE, RIGhT AXILLARY SENTINEL #1, BIOPSY - METASTATIC ADENOCARCINOMA INVOLVING ONE LYMPH NODE (2C, 2D and 2E), WITH EXTRACAPSULAR EXTENSION (2D) (1/1), (see comment). THREE LYMPH NODES, FREE OF TUMOR (0/3). PART 4: LYmPH nODES, RIGHT AXILLARY SENTinEL #3, BIOPSY -- 1cs-0-3 FIVE LYMPH NODES. FREE OF TUMOR (0/5). Chrcnonu, ingi/msHy oluctl, nos 850s/3 PaRt 5: breaSt, Right, new SuperiOr mArgin, exciSiOn - FIBrOaDipOSe TiSSUE. nO TumOr seeN Sih;husst, No3 C50.9.7f31n h PARt 6: LympH NODES, RIgHt INTERNAL mAmmARy, BIOPSy - ThRee Lymph nODeS, Free Of TumOr (0/3). SYNOPTIC - PRIMARY iNVASIVE CARCINOMA OF BREAS1 LATERALITY: Right PROCEDURE: Simple mastectomy LOCATION: Upper outer quadrant Lower outer quadrant SIzE Of TumOR: Maximum dimension invasive component: 2.5 cm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: Yes TUMOR AGGREGATE SIZE: Sum of the sizes of muitiple invasive tumors: 5.3 cm TUMOR TYPE (invasive component): Ductal adenocarcinoma, NOS NOTTINGHAM SCORE: Nuclear grade: 2  UUID: 6721193F-FE9D-4573-BF2A-ABAECF57DFD9 Tubule formation: 2 TCgA-bh-A0AZ-01a-PR Redacted Mitotic activity score: 2 Total Nottingham score: 6 Nottingham grade (1, 2, 3): 2 1 ANGIOLYMPHATIC INVASION: No DERMAL LYMPHATIC INVASION:S No CALCIFICATION: No Tumor type, in situ: Cribriform DCIS admixed with invasive carcinoma Percent of tumor occupied by in situ component: 1 % SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No SURG MARGINS INVOLVED BY IN SITU COMPONENT:E No PAget's DIsEASE Of nIpple: No IPAAD LYMPH NODES POSITIVE: 1 ual/Sy LYMPH NODES EXAMINED: 13 METHOD(S) OF LyMPH NODE EXAMINATION: H/E stain SENTINEL NODE METASTASIS: Yes SIZE OF NODAL METASTASES: Diameter of largest lymph node metastasis: 10 mm LYMPH NODE METASTASIS(-ES) WITH EXTRACAPSULAR EXTENSION: Yes NON-NEOPLASTIC BREAST TISSUE: Fibroadenoma, FCD I Stage, paihulugic: N Stage, patholOgiC: pT2 M STAgE, PATHOLOGIC: pN1 ESTROGen RECEpTOrS: pMX DDAA positive
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diff --git a/output/text/5affb2f7-cbee-430f-b0ce-d48d5b65de4e.txt b/output/text/5affb2f7-cbee-430f-b0ce-d48d5b65de4e.txt
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index 0000000000000000000000000000000000000000..29ed2a7d043f0fbc6ee7251409618e804572f283
--- /dev/null
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+
+--- Page 1 ---
+Sex: Female D.O.B.: Ref Physra.! RESSSRESANCRSRECIMENINPO Collected: Received: Reported: SURGICAL PATHOLOGY REPORT ADDENDUM REPORT BREAST PROGNOSTIC PANEL: Block(A4) REFERENCE RANGES RESULT TEST  1% is Positive POSITIVE (93%) Estrogen Receptor:  1% is Negative Staining Intensity: Strong  1% is Positive POSITIVE (60%) Progesterone Receptor:  1% is Negative Staining Intensity: Strong > 20% is High HIGH (32%) Ki-67 (MIB1) Proliferation Marker. 10-20% is Borderline <10% is Low 0-1+Negative EQUIVQCAL (2+ staining) Her2 by IHC: 2+ Equivocal 3+Positive  Weak, circumferential membrane staining in > 10% of cancer cells or <30% with strong complete membrane.staining A reflex to HER-2/neu by FiSH (fluorescent in situ hybridization) will be performed and an additional report will follow. Slides from this sample These results were interpreted at. .yas. Stanuaru assay conditions were met, including cold ischemia time and fixation  were evaluated and deemed adequate for ER/PR/Ki-67/.... parameters. All controls show appropriate reactivity.. UUID: 58978086-7443-4721-854B-877CE0FC10C0 TCGA-AC-A6IV-01A-PR Redacted [Specific testing information and references have been added to the microscopic description] The original diagnosis remains unchanged.. Addendum Report Issued by.. 1cD6-3  DIAGNOSIS: CtC F nbS A. Right breast mastectomy:. Invasive mammary carcinoma. Favor pleomorphic lobular carcinoma. Size: 2.2 cm. Architectural score: 3 ot 3. Nuclear score: 2 ot 3. srcenosro 8524/B Mitotic score: 2 of 3. W/stuer Tygso Total score: 7 of 9. Grade 2. Prognostic panel will follow as an addendum. Sut: RS Buesst nss Cso.9 No evidence of in situ carcinoma. No evidence of angiolymphatic invasion. StO b117/13 All surgical margins of excision are free of carcinoma.. Closest margin is deep and is 1.5 cm. B. Right axillary sentinel lympn nade: One lymph node, Metastatic carcinoma. Size of involvement within the node: 0.3 cm.
+
+--- Page 2 ---
+No evidence of extracapsular extension. Confirmed by staining for pancytokeratin.e TMN: T2pN1 Electronic Signature: MAASAMAACLINCALINFORMATION HSANPSEEAANSCSR CLINICAL HISTORy: Preoperative Diagnosis: Right modified radical mastectomy with sentinel node mapping with frozen section. Invasive mnammary carcinoma. ER positive. PR positive. Her-2 negative. Postoperative Diagnosis: Symptoms/Radiologic Findings: SPECIMENS: A. Right breast B.Right axilla sentinel node GROSS DESCRIPTION: A. The first container A is received labeled with the patient's name ight breast.The specimen consists of portion of fibroadipose breast  tissue and overlying skin measuring 20.0 x 16.5 x 6.0 cm and weighs 643 grams. The skin surface measures 20.0  9.2 cm, is light tan, wrinkled. There are no lesions seen grossly. The nipple Is eccentrically placed and appears grossly unremarkable. There is no arientation given to the specimen. The  margins have been inked yellow with the exception of the deep margin, which has been inked black. Sectioning reveals a firm gray-tan ill-defined mass that measures 2.2 x 2.0 x 1.8 cm that is 1.5 cm from the deep margin and is 2.7 from the closest lateral rnargin. The surrounding breast tissue reveals.  yellow-tan fatty fibroadipose tissue. There are no other lesions identified. At the periphery of the breast, there are no lymph nodes identified. Received  with the soecimen are three cassettes, one yellow, one green and one blue labeled Representative sections are submitted in cassettes labeled follows: nipple block 1; deep margin overiying the mass in block 2; sections from the mass in blocks 3 through 7; random sections taken nron all tour quadrants in blocks 8 through 11 B. The second container B is received in formalin labeled right axilla sentinel node.The specimen consists of a portion of fibroadipose  tissue that measures 3.5 x 2.0 x 1.5 cm. Sectioning reveais a singie rymph node that measures 1.8 x 0.7 x 0.9 cm. The lymph node is sectioned and is.  entirely submitted in two cassettes labeled. MICROSCOPIC EXAMINATION: THERAPEUTIC MARKER ASSAY CONDITIONS Breast Cancer Analysis using Immuno-histochemistry, and Pathologist review. is an automated digital slide creation, rmanagement, viewing and computer-assisted analysis system which aids the pathologist in the detection, classificatian, ER/PgR,  and counting of cells of interest thereby standardizing slide scoring through quantitative. HER2/neu Scoring assessment of marker intensity, size and shape. This laboratory uses a nodified version nf a FDA.  approved test. An antibody other than the FDA approved antibody for the system algorithn is used. The performance characteristics of these assays have been determined by Performance characteristics refer to the analytical performance of the test. Cold Ischemic  Specimen should be placed in neutral buffered formalin within 1 hour of removal from the patient Time, Fixative, and fixed for a minimum of 6 but not in excess of 48 hours. Specimen are processed by routine Processing tissue processing methods. Staining Method Used Staining platform, antibodies and associated reagent below are all manufactured by and are FDA approved. ER - Anti-Estrogen receptor (clone SP1) primary antibody is a rabbit monoclonal antibody (IgG) that. is used for the qualitative detection of estrogen receptor antigens.  PgR - Anti-Progesterone Receptor (clone 1E2) primary antibody is a rabbit monodlonal antibody Primary (IgG) that is used for the quantitative detection ot the A, B and C isoforms of human progesterone. Antibodies receptor antigens. Ki-67 -Anti-Ki-57 primary antibody is directed against the C-terminal portion of the Ki-67 antigen which is expressed in the nuclei of proliferating cells (normal and neoplastic). The antibody identifies  proliferating activity in sections of formalin-fixed, paraffin-embedded tissue on an automated slide  stainer platform.  HER-2/neu -- PATHWAY Anti-HER-2/neu (485) primary antibody is a rabbit monoclonal antibody M (IgG) that is used for semi-quantitative detection of HER2 antigens. ER, PR, HER-2/neu are prepared from sections of formalin-fixed, paraffin-embedded tissue on an  automated slide stainer platform.e Controls All Controls show appropriate reactivity (high protein expression, low protein expression, negative.  protein expression, internal elements from normal breast tissue included with sampie. Antigen A tris based buffer with a slightly basic pH , which, at elevated temperatures is capable of hydrolyzing.  Retrieval Type the covalent bonds formed by formalin in tissue Detection  System Type Indirect biotin streptavidin detection system
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diff --git a/output/text/5b262346-471f-4eec-9602-55e40f4e1846.txt b/output/text/5b262346-471f-4eec-9602-55e40f4e1846.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2141f8db44e8a1f5b65c44b40a4e162caedb5faf
--- /dev/null
+++ b/output/text/5b262346-471f-4eec-9602-55e40f4e1846.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Pathology Report Accession Number:eo. Report Status: Final Type: Surgical Pathology Specimen Type: Liver partial resection Procedure Date: Ordering Provider:' CASE: PATIEN Resident: Pathologi PATHOLOGIC DIAGNOSIS: A. SPECIMEN DESIGNATED "LEFT LOBE LIVER WEDGE (1O4g)" (including FSA): METASTATIC ADENOCARCINOMA, 5.0 cm, involving liver parenchyma. Parenchymal resection margin is negative for tumor. Tumor is 1.0 cm from the parenchymal resection margin. Hepatic steatosis, mild. B. SPECIMEN DESIGNATED "SIGMOID COLON": ADEnOcARciNOMA with mucinous differentiation, high grade, poorly. differentiated (5.0 cm in greatest dimension). Tumor is located in sigmoid colon, forms a fungating mass, is ulcerative, and has an infiltrating border.. Tumor invades through muscularis propria into serosa. Resection margins are negative for tumor.. Invasive tumor is 5.0 cm from the 4.9 cm stapled resection margin,. 7.0 cm from the 3.6 cm stapled resection margin, 2.6 cm from the. mesenteric resection margin, and <0.1 cm from the serosal surface.. Lymphovascular invasion is not identified. Extramural venous invasion is not identified.. Perineural invasion is not identified. Peritumoral lymphoid response (including Crohn's-like infiltrate) is not present. Residual adenoma is absent. Tattoo. Regional lymph nodes (positive:total): 2:17. AJCC Classification (6th edition): pT3c N1 M1. C.  SPECIMEN DESIGNATED "PROXIMAL DONUT":S Portion of colon, negative for tumor. D. SPECIMEN DESIGNATED "DISTAL DONUT": Portion of colon, negative for tumor.. CLINICAL DATA: History: Colon cancer. Operation: Laparoscopy, wedge resection L lower lobe of liver and low anterior resection. Operative Findings: Not provided. Clinical Diagnosis: Colon Ca. TISSUE SUBMITTED: A/1) left lobe liver wedge (Fs and Tissue Bank). B/2) sigmoid colon - Tissue Bank. c/3) proximal donut. D/4) distal donut. O.R. CONSULTATION: SPECIMEN LABELED "#1 - LEFT LOBE LIVER WEDGE" (FSA): Metastatic adenocarcinoma. Surgical resection margin,  negative for tumor. Page: I of3
+
+--- Page 2 ---
+Pathology Report The senior physician certifies that he/she personally conducted a gross and/or microscopic examination of the described specimen(s) and rendered or confirmed the rapid diagnos(es) related thereto. GROSS DESCRIPTION: The specimen is received fresh, in four parts, each labeled with the patient's. name and unit number. Part A, "left lobe liver wedge", consists of a 100.4-g liver wedge resection (9.0 x 7.2 x 4.2 cm) with a cauterized parenchyma1 resection margin (9.0 x 4.2 cm, inked blue).  On cut sectioning, there is a white/tan focally (approximately 10%) necrotic tumor (5.0 x 4,5 x 3.0 cm) that grossly abuts the liver capsule (inked black) and is located 1.0 cm to the parenchymal resection. margin. 'A representative section of the parenchymal resection margin is submitted as FsA.  A representative section of tumor and normal liver is submitted for tissue banking. Representative sections are submitted for histological examination. Micro A1: FSA remnant, 1 frag, Micro A2: Tumor, quick fix, 2 frags, Micro A3: Tumor and capsule and tumor and uninvolved liver parenchyma, 2 frags,. RSS. Micro A4: Uninvolved liver, 1 frag, Part B, "sigmoid colon", consists of an unoriented segment of colon (16.8 x 2.9. cm in diameter) with two stapled resection margins (4.9 cm and 3.6 cm, both inked black). The specimen is open to reveal a centrally ulcerated mass (5.0 x. 4.0 x 1.2 cm) with raised borders that is 5.0 cm to the 4.9 cm stapled resection margin, 7.0 cm from the 3.6 cm stapled resection margin, and 2.6 cm to the mesenteric resection margin (16.8 x 2.3 cm, inked orange).. There are. two tan/black tattoos (#1 5.0 x 2.5 cm and #2 4.0 x 3.5 cm). Tattoo #1 is located 2.6 cm to the 4.9 cm stapled resection margin and 1.2 cm from the ulcerated mass. Tattoo #2 is located 4.1 cm to the 3.6 cm stapled resection margin and 1.2 cm from the centrally ulcerated mass.  Tattoos #1 and #2 are located 7.2 cm from each other and are on opposite sides of the ulcerated mass. Underlying the tattoo #1 is a submucosal firm nodule (0.8 x 0.8 cm) that is located 0.8 cm from the 4.9 cm stapled resection margin and 4.0 cm to the ulcerated mass. Underlying tattoo #2 is a submucosal nodule (1.0 x 0.8 cm) located 6.1 cm to the 3.6 cm stapled resection margin and 2.5 cm from the ulcerated mass. There is an area of serosal puckering immediately deep to the centrally ulcerated mass (1.5 x 0.5 cm) that is located 4.0 cm from the mesenteric resection margin, 7.5 cm from the 4.9 cm stapled resection margin, and 7.0 cm from the 3.6 cm stapled resection margin. Gross photos are taken and representative sections are submitted for histological examination. Micro B1: 4.9 cm stapled resection margin to include 0.8 cm submucosal nodule; perpendicular, 1 frag, Micro B1: 3.6 cm stapled resection margin, perpendicular frag Micro B3: Remainder of 0.8 cm submucosal nodule, 1 frag, Micro B4: 1.0 cm submucosal nodule, 2 frags, Micro B5: Mesenteric resection margin, perpendicular, 1 frag, Micro B7: Tumor and adjacent uninvolved mucosa closest to 3.6 cm stapled resection margin, 1 frag, Micro B9: Tumor, 2 frags, Micro B10: ? matted lymph nodes (1.8 x 1.5 x 0.8 cm), bisected, 1 frag, Micro B11: Micro B12: Micro B13: 4 lymph node candidates, 4 frags, Micro B14-B17: Pericolonic adipose tissue, 1 frag each, Part C, "proximal donut", consists of a circular tan/pink soft tissue fragment (1.1 x 1.6 cm in diameter) that is 'attached to metallic anvil and contains a Page: 2 of 3
+
+--- Page 3 ---
+Pathology Report. black stitch. The specimen is entirely submitted for histological examination. Micro C1: Proximal donut, 1 frag, Part D, "distal donut", consists of a tan/yellow soft tissue (1.5 x 1.2 x 0.5 cm) which is entirely submitted. Micro D1: Distal donut, 1 frag, CASE NUMBER By his/her signature below, the senior physician certifies that he/she personally conducted a microscopic examination ("gross only" exam if so stated) of the described specimen(s) and rendered or confirmed the diagnosis(es) related thereto.. Final Diagnosis by. Electronically signed on Page: 3 of 3
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diff --git a/output/text/5b5d6c6e-3057-4ff7-bb39-4a38d00e568e.txt b/output/text/5b5d6c6e-3057-4ff7-bb39-4a38d00e568e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..38a4b6b54c3f13fd680adc202e507b85d9361fcf
--- /dev/null
+++ b/output/text/5b5d6c6e-3057-4ff7-bb39-4a38d00e568e.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+FINAL DIAGNOSIS:  AtrOphic OVary with OVarian FiBrOma, 1.2 Cm. A. B. Fallopian tube with multiple paratusal cysts. C. THERE IS NO eVIDENCE OF MALIGNAnCy. TCGA-AZ-4681 A.  ATROpHiC OVARy WITH OVARIAN FiBROMATA, 2.8 CM AND 2.0 CM.  FAllOPIan TuBE WITh PArATubal CySTS. C. there is no evidence Of malignancy. Part 3: rectum, proctectomy   Rectal Adenocarcinoma, mOderately Differentiated, 2.5 Cm In greatest extent. A.  TUMOR EXTENDS THROUGH THE FULL THICKNESS OF THE MUSCULARIS PROPRIA iNTO PERIRECTAL ADIPOSE TISSUE. C. THE MARGINS OF RESECTION ARE FREE OF MALIGNANCY. D EIGHt LyMPH nODES, nO TUmOR SEEN (0/8). E. HISTOPATHOLOGIC STAgE: pTNM = T3 NO MX. F.  INCIDENTAl HYPERPLASTIC POLYPS. G.  DIVERTICULAR DISEASE. PART 4: REctUm, MArgINS, RESECTION - REctum, NO TumOR SEen. PArt 5: colon, Right, Right hemIcolectomy  A. COlOnIc ADenOcarcinomA, mOderateLy DiFfERentiateD, 2.5 Cm In GrEaTESt Extent. B. TUmOR EXTEnDS tHROUGh THE FULL THICKNESS OF tHe MUSCULARIS PROpRiA, INTO PERiCOLONIC ADIpOSE TISSUE. C. THE MARGINS OF RESECTION ARE FREE OF MALIGNANCY. D. FiVe Lymph NoDeS, NO TumOr SEen (0/5). E. HISTOPATHOLOGIC STAGE: pTNM = T3 N0 MX. F. AppenDix WIth fIbrOus OBliteratiOn Of the Tip. G.  DIVERTICULAR DISEASE. PART 6: GALLBLADDER, CHOLECySTECTOMy -- CHRONIC CHOLECYSTITIS AND CHOLELITHIASIS.
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diff --git a/output/text/5b966383-6041-4ce4-b287-637da2540c40.txt b/output/text/5b966383-6041-4ce4-b287-637da2540c40.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a58e3c3c35206b4720e662c32f0afe06333ad112
--- /dev/null
+++ b/output/text/5b966383-6041-4ce4-b287-637da2540c40.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+K,yl Fratng Duct fanm, vc's Iw 35vc}3 11220 Sts: busnt,nos c50'7 page 1 / 2 Department of Cancer Pathology copy no. Examination: Histopathological examination Examination No.: Patient PESEL: Age. Gender: F Material: Multiple organ resection -- right breast Unit in charge: Physician in charge: Material collected on Material received on: Expected time of examination: up to 8 working days Clinical diagnosis: Bifocal cancer of the right breast..  Examination performed on:e Results of immunohistochemical examination: Estrogen receptors in neoplastic cell nuciei not found. Progesterone receptors in neoplastic cell nuclei not found. HER2 protein stained with HercepTest" by DAKO. Negative reaction in invasive cancerous cells (. Score = 1+ ) Compliance validated by:  Examination performed on  Results of immunohistochemical examination: Assessment of the receptor status for the other tumour (prep. IH)Estrogen receptors found in 10-75% of  neoplastic cell nuciei. Progesterone receptors found in 10-75% of neoplastic cell nuclei. HER2 protein stained with HercepTestM by DAKO. Negative reaction in invasive cancerous cells ( Score = 1+ ) Compliance validated by. Examination performed on: Macroscopic description: Right breast, sized 22.5 x 17 x 4 cm, removed along with axillary tissues sized 9 x 6 x 7 cm and a skin flap of 20 x 9 cm. Weight 600 g. Tumour sized 4.5 x 2.5 x 2.3 cm on the border of the lower quadrants, placed 6.7 cm from the lower edge, 1.1 cm from the base and 1.6 cm from the skin.. The other tumour, sized 1.3 x 1.2 x 1.2, found 3 cm from the first one (margins: lower area 1.7 cm, base 1.4 cm, skin 0.9 cm). Lymph nodes of 0.4 cm in length, metastatic. Microscopic description:. Tumour 1 - Carcinoma ductale invasivum cum necrosi NHG3 (3 + 3 + 3/21 mitoses/10 HPF - visual area 0.55 mm). Focuses of carcinoma ductale in situ Dcis found within and outside the tumour (solid and flat type,. with high nuclear atypia and comedo necrosis < 10% of the tumour). Cancerisatio lobulorum.  Tumour 2 - Carcinoma invasivum mixtum partim ductale, partim papillare, partim cribrosum UUID:8EFA6C19-2FA1-4F23-AF7B-15681E8E930A TCGA-D8-A13Z-01A-PR Redacted
+
+--- Page 2 ---
+Examination: Histopathological examination page 2 / 2 Examination No.: : Patient:  PESEL Gender: F Examination performed on: NGH2 (2 + 2 + 2/9 mitoses/ 10 HPF/ visual area diameter 0.55 mm). Carcinoma intraductale ductuum mamillae.e Glandular tissue showing mastopathia fibrosa et cystica. AXILLARY LYMPH NODES:  Metastases carcinomatosae in lymphonodis (No Ix/xI).  Infiltratio capsulae lymphonodorum.. Emboliae carcinomatosae vasorum. Examination result: Carcinoma invasivum bifocale. Tumour 1 - Carcinoma ductale inyasiyum NHG3, pT2. Tumour 2 - Carcinoma invasivum mixtum NHG2, pTIc. (NHG3, pT2, pN2a). tVCTAL- INVASIVE cA&ciNN e validated by:
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diff --git a/output/text/5b9756cc-4a15-41eb-820d-5d19a33fe053.txt b/output/text/5b9756cc-4a15-41eb-820d-5d19a33fe053.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a57163b87ae4c3a99c02dbad0ac7626c9123469a
--- /dev/null
+++ b/output/text/5b9756cc-4a15-41eb-820d-5d19a33fe053.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+LARGE INTESTINE TISSUE CHECKLIST Specimen type: Hemicolectomy Specimen size: Not specified Tumor site: Colon Tumor size: 9 x 8.5 x 8 cm Tumor features: None specified Histologic type: Adenocarcinoma Histologic grade: Poorly differentiated Tumor extent: Pericolonic tissues Lymph nodes: Not specified Margins: Not specified Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified. Comments: None
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diff --git a/output/text/5bb4daa3-c0d2-4817-84fc-c5a133c1a092.txt b/output/text/5bb4daa3-c0d2-4817-84fc-c5a133c1a092.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8533feb8102cdadadb6ee7611adbe01b9c53fefc
--- /dev/null
+++ b/output/text/5bb4daa3-c0d2-4817-84fc-c5a133c1a092.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+FINAL DIAGNOSIS RIGHT KIDNEY,LOWER POLE, PARTIAL NEPHRECTOMY A.  RENAL CELL CARCINOMA, CONVENTIONAL (CLEAR CELL) TYPE. FUHrmAn nUClEar GRaDe iS 2 of 4.. B. C.  MAximal tumor Diameter is 3.0 cm. D. CArcinoMA is cOnFined to tHe kidney, wiThout extracapsuLar exTenSion.  NO ANGIOLYMPHAT!C INVASION IS IDENTIFIED. ALL ASSESSABLE SURGICAL RESECTION MARGINS ARE FREE OF THE NEOPLASM (See Comment).E F. Non-neoplastic kidney (which is adjacent to the tomor) shows moderate arterial?. G. ARTERIOLAR SCLEROSIS AND MODERATE GLOBAL GLOMERULOSCLEROSIS, WITH WELL-PRESERVED TUBULES AND INTERSTITIUM. TNM PATHOLOGIC STAGE: pT1a NX MX (See Synoptic).
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diff --git a/output/text/5bf8643d-223f-4ecd-a41d-9509e14edde5.txt b/output/text/5bf8643d-223f-4ecd-a41d-9509e14edde5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4c80029b6a59cf49ba1caf24681b131d761e4baa
--- /dev/null
+++ b/output/text/5bf8643d-223f-4ecd-a41d-9509e14edde5.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+page 1 / 2 Department of Cancer Pathology copy No. Date: Examination: Histopathological examination Internal invoice No. Cost of diagnostic procedure Examination No.: Patient: xxx PESEL: XXX Age: Gender: F Material: Total organ resection -- feft breast with axillary tissues /cs-0-3 Unit in charge: mfiltnntrng ouct, nos 85oo]: cbLcii0mo, Physician in charge: Site: bresot, Nos c50.9 Material collected on: : Material received on: Expected time of examination: up to 8 working days Clinical diagnosis: Cancer of the left breast.. Examination performed on: Results of immunohistochemical examination: Estrogen receptors found in over 75% of neoplastic cell nuclei. Progesterone receptors found in over 75% of neoplastic cell nuclei. HER2 protein stained with HercepTestTM by DAKO. Score = 2+, FISH verification recommended. Compliance validated by. Examination performed on' : Macroscopic description: Left breast sized 22 x 15 x 5 cm removed along with axillary tissues sized 13 x 7.5 x 1.5 cm and a skin flap of 19 x 11 cm.  Retracted nipple. Tumour sized 2.5 x 2 x 2.8 cm found on the boundary of lower quadrants, located 3.5 cm from the lower boundary, 0.4 cm from the base and 3 cm from the skin. Microscopic description: Carcinoma ductale invasivum - NHG2 (2+2+3/21 mitoses/10 HPF - visual area 0.57mm). Glandular tissue showing lesions of the type mastopathia fibrosa et cystica, hyperplasia ductalis simplex (uDH ). AXILLARY LYMPH NODES:E Metastases carcinomatosae in lymphonodis (No III/xxill). Infiltratio capsulae lymphonodorum.. Histopathological diagnosis:e Carcinoma ductale invasivum mammae sinistrae. Invasive ductal carcinoma of the left breast. Metastases carcinomatosae in lymphonodosi axillae (No IIl/xxIll) (NHG2, pT2, pNla). Cancer metasta +s of axillary lymph nodes (No ll/xxilt) (NHG2, pT2, pNla). Compliance validated by: Examination performed on: UUID:E69CF3E3-4799-4892-87E9-4291814A189C0 TCGA-D8-A1X9-01A-PR Redacted
+
+--- Page 2 ---
+page 2 / 2 Examination: Histopathological examination Examination No.: Patient: xxx PESEL: XXX Gender: F Examination performed on: Results of immunohistochemical examination: RESULT OF HER2/neu GENE AMPLIFICATION with the FiSH method by Path Vysion HER2 DNA Probe Kit FINAL RESULT: HER-2 GENE AmPLIFICATION NOT FOUND Compliance validated by: CONTACT YOUR DOCTOR WITH THIS REPORT!
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diff --git a/output/text/5c0969d9-bfa6-4813-a830-f02819105a6e.txt b/output/text/5c0969d9-bfa6-4813-a830-f02819105a6e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0b0324f8835eba6a55ae2b2849aaa9dcfe7828ed
--- /dev/null
+++ b/output/text/5c0969d9-bfa6-4813-a830-f02819105a6e.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:1304F817-A20A-4EBC-9CC8-15S4808AC1F6 TCGA-AN-A046-01A-PR Redacted TSS Patient ID Case #:' DOB: Sex: Female Ethnicity (Race): Cancer Samplea Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma Date of Procurement Anatomic Site: Right Breast Tumor location: Primary Tissue Specification: Tumor Specimen Matrix: Tissue Specimen Format: Frozen Container: cryomold Type of Procurement: Radical mastectomy Grade: 2 T Stage: 2 N Stage: 0 M Stage: 0 Treatment: none Treatment Details: n/a  Normal Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw Matrix: Blood Specimen Format: frozen Container: tube Date of Procurement: 1cs-0-3 cancima, mfilt^nhxq duct,nvs 85ccf3 Sife: brast, Nu; c50.9 10/21fu
\ No newline at end of file
diff --git a/output/text/5c19e64b-9f5f-45bc-8bca-4348e9844856.txt b/output/text/5c19e64b-9f5f-45bc-8bca-4348e9844856.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f72742bbf2ba31150bb910ed433648eeba28f826
--- /dev/null
+++ b/output/text/5c19e64b-9f5f-45bc-8bca-4348e9844856.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+IcDO -3  UUID: 899CC957-3E0E-4452-9D36-B9EDBF28FDC8 Redacted Careinsms reual ceIl TcgA-Uw-A7gU-01z-pr Chomsphobu type 8317|3 Surgical Pathology Report tJ 9/24/3 Diagnosis: A: Resection bed, left kidney, biopsy - Renal parenchyma with mild chronic interstitial inflammation - No evidence of malignancy B: Resection bed, right kidney, removal. - Renal parenchyma with mild chronic interstitial inflammation - No evidence of malignancy C: Mass, Left kidney, resection - Renal cell carcinoma, chromophobe type, eosinophilic variant, 2.6 cm, without vascular or extracapsular invasion, surgical margins involved by renal cell carcinoma (see comment) D: Mass, right kidney, resection - Oncocytoma, 1.4 cm, surgical margins negative (see comment) COMMENT: Immunohistochemical stains were performed on parts C and D with appropriate controls. The lesion in the left kidney was positive for CD117and CK7 and negative for vimentin. These findings are consistent with chromophobe variant of renal cell carcinoma. The lesion in right kidney was positive for CD117 and negative for vimentin and CK7. These findings are consistent with oncocytoma. This case was shown in consultation to Drs. and who concur with the diagnosis.. Intraoperative Consult Diagnosis: A frozen section was requested by Dr. in . FSA1: Resection bed, left, biopsy. - No carcinoma identified FSB1: Resection bed, right kidney, biopsy. - No tumor seen. Drs. and on Frozen Section Pathologist:, MD PhD Clinical History: -year-old male with bilateral renal masses.
+
+--- Page 2 ---
+Gross Description: Received are four formalin-filled containers. Container A: Received fresh for frozen section is a 2 x 1 x 0.3 cm aggregate of multiple red/tan soft. tissue fragments which were frozen as FSA1, Container B: Received fresh for frozen section is an 8 x 7 x 4 mm red/tan soft tissue fragment which was frozen as FSB1. Container C is additionally labeled "left renal mass." It holds a 5.2 gram, 2.9 x 2.4 x 2.0 cm partial nephrectomy specimen which is intact and has an identified pink to golden yellow glistening capsular surface and a golden pink parenchymal surface. The parenchymal margin is entirely inked blue. Sectioning exhibits a solid and cystic (mainly cystic) mass measuring 2.6x2.1x0.6 cm with a glistening gelatinous pale golden yellow cut surface. The mass focally abuts the blue inked parenchymal margin.. Two central full thickness sections are submitted in blocks C1 and C2. The remaining portions of each. half is further sectioned and submitted in blocks C3 and C4, Container D is additionally labeled "right renal mass." It holds an unoriented 1.2 gram, 1.8 x 1.3 x 0.9 cm partial nephrectomy specimen with an identified capsular surface which is golden pink, smooth and glistening with loosely adherent fibroadipose tissue and a golden pink parenchymal surface. The. parenchymal margin is inked blue. There is a 1.3 x 1.4 x 1.0 cm palpable nodule which causes distortion of the capsular surface. Upon sectioning, this mass is mainly solid and has a relatively homogeneous golden yellow cut surface. The mass is serially sectioned and entirely submitted in blocks D1 and D2, 8/31
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diff --git a/output/text/5c275a13-ddec-45c6-bdd0-d4a0d5680e8d.txt b/output/text/5c275a13-ddec-45c6-bdd0-d4a0d5680e8d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ab9e7540ce9e3b05680430ee9e658570635d03f4
--- /dev/null
+++ b/output/text/5c275a13-ddec-45c6-bdd0-d4a0d5680e8d.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Jcs -0-3 Carunomn, nfiltnafiny chuc+cl, Nos 85mt/3 Puth Sif: 3wsst,uoq C5o.4 1/21f1 CQCF Sihe: Brsgt,Nos C5o.9 Diagnosis: Invasive ductal breast carcinoma (maximum diameter 5.5 cm, malignancy grade III) with angioinvasion and a mediocranial safety margin at least 3 mm wide. Tumor classification: G3 (L0, V0), pT3, Nx, Mx Diagnosis: Tumor-free lymph nodes (total N = 1 1, pN0) UUID:738B601A-24D8-4261-8000-1986482130700 Redacted
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diff --git a/output/text/5c3a6cb5-1636-4994-9843-2424f56b6af3.txt b/output/text/5c3a6cb5-1636-4994-9843-2424f56b6af3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5aa75e5369cdeed595bbe97813bae2983a8369e9
--- /dev/null
+++ b/output/text/5c3a6cb5-1636-4994-9843-2424f56b6af3.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:069BFE2C-691F-4D48-BA0D-554678931C59 TCGA-2Z-A9J7-01A-PR Redacted Pathology Report Gender Services: Racetved: Reportedr. Submitsing Pryatcians: Fatnoicgistr Intraop:Fatnologist Fertormsng Fhysici3n CLINICAL HISTORY SUBCUTANEOUS LESION ON FATIENT WITH LARGR RENAL MASS. ICD Or3 I ceQ0 PPEOPERATIVE DEAGNOGIG: NA J 8c6tJs3 SFECIMEN TYPR (S) s: Site Byhidney NsS A:RIGRT ANTERIOR CHEST WALL LESICN B.. RICHT RADICAL NRPHRECTCMY C.64.9 C RIGHT PSOAS MUSCLS MASS CJU 4|38J1y FENAL DIAONOSIS A RIGHT ANTERIOR CHEST WALL LESICN Yetaatat:c renas cell carcirona with sarcomatoid teaturea, Bee comment. Cormenr: Immunchieochemical stains witn.adequatecogtrols were perrormed on block. abeled.Al toturtner snvestigate tnss.csse.Tne.reoplsstic cells.snow immunoreactivity witn pancytokeratin AE/3.ana vimentin..im.es-io sncwcocal.non apeciic resccivlty They 5ra negative win Tre-1, ck-s/6, cR7, ck2o, cD-10 and pan melanoma. B. RIGHT KIENEY, RADICAL NEPHRECTOMY Hapiilary renal cell carciaomawitn rocal.sarcomatoid teatures, see key Patrological Fndings. C. REGHT SOET MUSCLE MASS: Metsatatte carc:noma,a:milar to part A nxesnrgical.nargin negative roe uor KEY PATIIOLOGICAL FINDINGS Proceturey Rignt radieal nephrectory Tumor cypex Papiliary renal cell carcinoma, witn tocal aarcomato:d Teasures Nucleax grade : Grade IIx Pattern ot growth Fapillary and nerorrhagic Tumor aize 12x11.5x9 Tumor location: Superior media aspectst tre kdney Ranal capsule invaaion: The tumor penetrates.into but:nobeyond tne renal Capsule, Invsaion ot Cerota' Faacia:. Not identisied Henal yein invasdnx Not present Surgicak margine. Vaacular.and ureter margina negative ror tumor: Non-neopiastic k:dney: No.signsticans patneiogia changes. Adrenal gland: Not exained Lymph sodes? Not .examined atnolonid atsge E2XMX Yes M.D. the attending patnolcgist,.personaliy reviewed :te entire pathiogy case and xerdered the rinal diagnosis, slectronicaiiy signed out ry OTHER.RELATEDCLINICAL EATA: NA
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+INTRAOPEPATIVE DEAGNOSES: FROZEN SECTION DEAGNOSES FSAL. RIGHT ANTERIOR CHEST WALL LEGION: Pcorly dirrerentsatea carcinona, probably xianey. cCMMENr: Tnis rrozen section dsagrosis/resuit w3s co smunic3ted.to andacxnoxlcge Dy X.D... have pertormed the, Intracperative. censultatson(s ano issued the atove dagnoees at CROSS. DESCRIPT:ON: A Specimen is recoivos trean latelnd *leaton rgnt anterior chest-wall.The gpecimen.consista or an ovoid, noderataly cir, tan-wnite to tan-pink.aoduie eaauring.5xxl0.cm.rne.margin ot reaections are tnked inDlack. The apecimen ie ser:ally aectloren.to revaal tan-white to tan-p:nx parciaily recrotic cut. surrace.Representatiye tresn tianue is autmited to Tigsue Procurement. Laboratory. Representatye sections are submitted tor rrozen secsicu evaluation aa Fsal, and tne renaining tissue is entirely eurmltced as Al-a2. B. specimen ia ceceved.rresn lateled "right radicsl.nephrecrcmy*. Tre speci=en censiats o: a 604. gran xidney surrcunded by an Arreguiar tibroadipce.ciaaue envelopo measuring 15.0 * 14.0'x 9,s. cx in overall d:nensicn.. Prior to sectacning the.specnen, the.perinepnric rat is.inxed in blsck. on sectaning there ie an ovoid cucor maasIacated in the.supersor-mediat arpect orsne kidneyrne tumor nass,12.0 x.11.5.x $.0 cm, ts apherical, xan-yeliow to tan-prown, and.there:are aress ot.namorrhagi and necroate. The.tumor does not invace tne caltceal 'aystem. and does not.invade tne renal sinus the tumcr.does not peretratetnrough the .reral capsuie to invoive.treperinepnric rat. Tne .tuor ia weil-denarcae1 rrom.tne uninvolved renal.parerchyms. Additional. tumor nodules are not groesy.tdertirie Tne meduilary cord, cal/ces and renal pelvia, are unremarxabie. attacned to tne kidney as a s.0 cm lergtnor ureter wnicn ia unremarkabieTne ranal arteryreyeals ntld acherosclerotic changes and tre renal vein ia rct groseyirivoived by cumor. The.adrenal gland is not iaertiried, dn secticning ne nilar rat, ro lympn nodes are Jsolated Representatye Iresn clssue lg aunmicced to Tasue Procurement Laboratory. NepreBantative sectiona are subnlted aa tollous: Urater, vein. ann artery it margin of resectien. 2: Tumor in relation to inkedpernephria tat. margin or reaection rumor ng. Entnvoived reral psrerchyma Ferlhilar ribreadipose rissue. C. Specimen is received rrenn labeted *rghr pscae musce mass. Tne apscimen consiate or 3n.ovoid, scderateiytirm, darxrea-Drown noduie, maaauring 37 x30x 2.0 cm. rhe specimen isaerialiy.aectcnedto reveal a tan-white to tan-pink partiai:y necrot:e cut. surrace. nepresentacive rrean tissue ss not aubmitcod to Tsaue Frocurezent Laboratdry..Representative secsionsareautmitte1 aa ci-c2
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+UUID:E422C6E8-084F-42B8-84E7-4EF387F098C7 TCGA-AC-A2QJ-01A-PR Redacted MRN:  Surqery Age: Sex: F DOB: Laboratory Patient Renort. Print Date/Time Criteria Surgical Pathology Histopathological Examination Path#: Collected: Received: Complete:C Pre-Op Diagnosis : Left Breast Cancer Order Physician 105-0.3 Specimens Dreast,  lert inrerior skin Larcinoma, mctp/asftr, NOS Breast,. left Lymph Node, Left Axillary 8575/3 Site : braot Nos c5o.9 Lymph Node, Sentinel Left Axilla Breast, left, inferior margin Frozen Diagnosis : Block# : A-1 lj 9/3fj Re-Ex? FS-Diag : No carcinoma identified. Comment : none Report : GROSS EXAMINATION: A. The specimen is received fresh in a container labeled. with the name of the patient and labeled as breast, left inferior skin. Tissue:  Triangular excision Size: 0.9 x 0.9 cm Deep: 0.3 cm Sutures: No Inked: No The specimen is entirely submitted for frozen section in one block. FROzEN SEcTION DIAGNOsIS: No carcinoma identified. B. The specimen is received fresh in a container labeled with the name of the patient and identified as breast, left.  The specimen consists of a mastectomy measuring en. bloc 19.5 x 15 x 6 cm and weighs 604 grams.  There is an anterior ellipse of skin measuring 14 x 7 cm. Medially located on the ellipse of skin is'a 5 cm areolar complex with everted nipple. Sections of nipple areola are sampled in block 1. 2 cm lateral to the areola is a 0.9 cm red-tan papule which is submitted in block 2. The superficial superior margin is inked orange and the superficial inferior margin is inked green. The deep margin is inked blue and THIS CONFIDENTIAL AND PRIVILEGED DOCUMENT/INFORMATION IS PROTECTED BY FEDERAL AND STATE LAW. UNAuThORIzED DiSCLOSURE, DISSEMINATION OR DUPLICATION IS PROHIBITED Path #: ' Page 1 of 4 Visit #:
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+the specimen sectioned, showing a red-tan oval mass in the lateral aspect of the breast. This mass measures 7 cm greatest dimension. It grossly extends to within 0.5 cm of the superior margin of resection which is submitted in block 3, 0.7 cm of the inferior margin of resection which is submitted in block 4, and 1 cm of the deep margin of resection which is submitted in block 5. Additional sections of the mass are submitted in blocks 6-9. The remaining. breast is composed of yellow lobulated adipose tissue admixed with islands of gray-white rubbery tissue. The breast is divided into four quadrants, upper inner, lower inner, upper outer and lower 'outer and sampled in blocks 10-13'respectively. No axillary tissue is present and no lymph nodes are identified. Formalin fixation time is 32 hours.. Ischemic time: 30 minutes. C. The specimen is received in formalin in a container labeled with the name of the patient and labeled as lymph node, left axillary:.  The specimen consists of an oval piece of tan-pink and yellow soft tissue which measures 2.1 x 1.8 x 1 cm. The specimen is sectioned and entirely submitted in three blocks.. D. The specimen is received in formalin in a container labeled with the name of the patient and identified as lymph node, sentinel left axilla. Pieces: 1 Specimen Size: 2.2 x 1.4 x 1.1 cm No. of Nodes: 1 Size of Nodes: 2.2 cm. The specimen is sectioned and entirely submitted in three blocks. E. The specimen is received in formalin in a container labeled with the name of the patient and identified as additional left breast tissue, inferior margin. Size: 14 x 6 x 2.5 cm Shape: Flattened oval. Spec Board: No. Radiograph: No Sutures: Yes; short superior, long lateral Inked: Anterior-Green,' Posterior-Blue, Superior-Orange, Inferior-Yellow, Medial-Red, Lateral-' Black. Sectioning shows no discrete masses.. Sections are submitted as follows: Full thickness superior to inferior sections l-6 with the remaining margins submitted as follows: anterior 7, posterior 8, medial 9,. lateral 10. Formalin fixation time is approximately 30 hours. Ischemic time: Unknown. DIAGNOSIS BASED ON GROSS AND MICROSCOPIC EXAMINATION: A. Skin, left inferior breast, biopsy:. - Skin with minimal patchy nonspecific chronic inflammation. - No maliqnancy identified. THIS CONFIDENTIAL AND PRIVILEGED DOCUMENT/INFORMATION IS PROTECTED BY FEDERAL AND STATE LAW. UNAUTHORIZED DISCLOSURE, DISSEMINATION OR DUPLICATION IS PROHIBITED Path #: Page 2 of 4 Visit #:
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+B. Breast, left, mastectomy: - Invasive metaplastic carcinoma, grade 3 (3+3+3), 7 cm in. greatest dimension, present within'3mm (0.3 cm) of superior margin, 5mm (0.5 cm)~of inferior margin, and 10mm (l cm) of deep margin. Invasive carcinoma invades dermis and is associated with overlying epidermal ulceration.. - Background nonproliferative fibrocystic including stromal fibrosis, apocrine metaplasia, microcystic formation, and duct ectasia. See canrer.  case snmmarv checklist. C. Lymph node, left axillary, biopsy:. One benign lymph node, negative  for metastatic carcinoma (0/1). - See cancer case summary checklist. D. Sentinel lymph node, left, biopsy:.  One benign lymph node, negative for metastatic carcinoma (0/1). - See cancer case summary checklist. E. Breast, left, re-excision of inferior margin:  Benign breast tissue with nonproliferative fibrocystic changes including apocrine metaplasia, stromal fibrosis, and microcyst formation. -- No malignancy identified.  The margins are examined microscopically and are. histologically unremarkable. - See cancer case summary checklist. CANCER CASE SUMMARY CHECKLIST SpECIMEN: Total breast (including nipple and skin) PROCEDURE: Total mastectomy LYMPH NODE SAMPLING: Sentinel lymph nodes and axillary lymph node biopsy SPEcIMEN INTEGRITy: Multiple designated specimens (main excision and identified margin). SPECIMEN LATERALITY: Left Tumor siTE (Invasive Carcinoma): Upper and lower outer quadrants Tumor size: Size of Largest Invasive Carcinoma: 7 cm (70 mm) in greatest dimension TUMOR FOCALITY: Single focus of invasive carcinoma MACROSCOPIC AND MICROSCOPIC EXTENT OF TUMOR: Skin: Invasive carcinoma directly invades into the dermis with associated skin ulceration. Nipple: Dcis does not involve the nipple epidermis. Skeletal Muscle: No skeletal muscle is present. DUCTAL CARCINOMA IN SITU (DCIS): No DCIS is preSent. LOBULAR CARCINOMA IN SITU (LCIS): Not identified. HISTOLOGIC TYPE OF INVASIVE CARCINOMA: InVasive metaplastic FEDERAL AND STATE LAW.  UNAUTHORIZED DISCLOSURE, DISSEMINATION OR DUPLICATION IS PROHIBITED Path #: Page 3 of 4 Visit #:
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+carcinoma. HISTOLOGIC GRADE: NOTTINGHAM HISTOLOGIC SCORE: - Glandular (Acinar)/Tubular Differentiation: 3 - Nuclear Pleomorphism: 3 - Mitotic Count:. 3 Number of mitoses per 10 high-power fields: 30. Diameter or microscope field: 0.55 mm Overall Grade: Grade 3 (score of 9) MARGINS: - Margins uninvolved by invasive carcinoma. Distance of invasive carcinoma to closest margin = 3 mm (0.3 cm), superior. - All other margins greater than 1 cm from invasive carcinoma (including specimens A and E) LYMPH-VAsCULAR INVASION: Not identified. Dermal Lymph-Vascular Invasion: Not identified. LYMPH NODES: Number of sentinel lymph nodes examined: Total number of lymph nodes examined (sentinel and nonsentinel):~ Number of lymph nodes with macrometastases (>0.2 cm): Number of lymph nodes with micrometastases (>0.2 mm to 0.2 cm and/or >200 cells): . 0 Number of lymph nodes with isolated tumor cells (<0.2 mm and <200 ce11s): 0 Size of largest metastatic deposit: Not applicable.. Extranodal Extension:  Not applicable. Method of Evaluation of Sentinel Lymph Nodes: H&E, 1 level PATHOLOGIC STAGING (pTNM): Primary Tumor (Invasive Carcinoma)(pT): pT4b (skin ulceration). - Regional'Lymph Nodes (pN): pNo (no regional lymph node metastasis identified histologically). Distant Metastasis (M): Not applicable. ANCILLARY STUDIES: Estrogen Receptor:. Performed on another specimen Results: No immunoreactive tumor cells present. Progesterone Receptor: Performed on another specimen - Results: No immunoreactive tumor cells present. HER2/neu Immunoperoxidase Studies: Performed on another specimen Results: Negative (score 0) Fluorescence In Situ Hybridization (FIsh) for HER2/neu: Not performed. Intradepartmental consultation obtained. M.D., Pathologist Flortroninallv Signed by: MD THIS CONFIDENTIAL AND PRIVILEGED DOCUMENT/INFORMATION IS PROTECTED BY FEDERAL AND STATE LAW.  UNAUTHORIzED DISCLOSURE,  DISSEMINATION OR DUPLICATION IS PROHIBITED Path # Page 4 of 4 Visit #:
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+Pa jic? Surg Path TCGA-B6-A0RH-01A-PR Redacted CLINICAL HISTORY: Left breast ca. GROSS EXAMINATION: A. "Left breast". Container additionally labeled with patient's name, history number and date. Fresh. A specimen from a left modified radical mastectomy. There is an ellipse of brown skin measuring 18.8 x 8.4 cm. Located somewhat medially and inferiorly on the ellipse is an unremarkable areola and nipple. No skin lesions or scars are noted. No nipple retraction or peau d'orange changes are noted. Underlying the ellipse of skin is breast tissue with overall measurements of 16.3 x 15.2 x 3.3 cm., and an attached axillary tail measuring 12.0 x 8.5 x 1.7 cm. The deep surgical margin is inked in blue, and the specimen is step sectioned. A 2.5 x 2.5 x 2.0 cm. firm white mass is seen underlying the skin ellipse at the medial edge of the areola at approximately the 9:0o position. This mass is relatively well-defined, but does appear to diffusely infiltrate into surrounding fat for a short distance along its outer edges. The cut surface is white, firm, and homogeneous; no necrosis is grossly identified. Tumor grossly extends to within 1.2 cm. of the deep surgical margin. Portions of the tumor are submitted for estrogen and progesterone. receptor analysis, and additional portions are submitted to the tissue bank. The remainder of the breast parenchyma is largely fatty, with interspersed, unremarkable appearing fibrous white parenchyma. No additional lesions are identified. Sections of the breast are submitted as follows:. Block Al - nipple and areola.. Block A2 - skin overlying tumor, medial aspect of skin ellipse. Block A3 - A4 - tumor. Blocks A5 and A6 - tumor and adjacent breast tissue.. Block A7,A21,A22 - deep margin.. Block A8 - left upper inner quadrant. Block A9 - left lower inner quadrant. Block A10 - sections from 9:00 (medial) breast, adjacent to tumor. Block All - left upper outer quadrant. Block A12 - left lower outer quadrant. The axillary tail is arbitrarily divided into three levels, with level 1 being that closest to the breast. The axillary tail is examined for lymph nodes. Several large but grossly benign nodes are identified, and numerous smaller nodes are present. Lymph node candidates are submitted as follows:. Block A13 - lymph node candidates from Level 1, with single large node inked and bisected.. Block A14 - single large lymph node from Level 1. Block A15 - lymph node candidates from Level 1. Block Al6 - lymph node candidates from Level 1.. Block A17 - lymph node candidates from Level 2, a single large node inked and bisected.. Block A18 - lymph node candidates from Level 2. Block A19 - lymph node candidates from Level 3. Block A20 - lymph node candidates from Level 3. MICROSCOPIC EXAMINATION:S The predominant part of the tumor has a cribriform pattern, and that includes the infiltrating part of the carcinoma. The tumor cells are characterized by moderately pleomorphic nuclei with prominent nucleoli. The mitotic rate varies from area to area, but 2-3 mitosis are observed in some high power fields. The I of2
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+Carcinom 1trstis ductrl No Site Code: srest, Nos C50.9 lumina created by the carcinoma often contains small numoers of hecrotic tumor 1+7/n l cells, but a classic comedo carcinoma is not identified. In some areas, a minor component of infiltrating tubular carcinoma is identified. Abundant desmoplastic stromal response accompanies the infiltrating neoplasm. In areas, lymphatic vessels within the breast parenchyma adjacent to the tumor, contain malignant cells. Adjacent to the tumor, intraductal carcinoma (cribriform. papillary types), is seen in focal areas. In a random section from the upper-outer quadrant (Block All), there is a focus of atypical ductal hyperplasia. No frank ductal, intraductal or infiltrating carcinoma is observed at this site.. DIAGNOSIS: "LEFT, BREAST" : LEFT MODIFIED RADICAL MASTECTOMY SPECIMEN WITH: 1. INFILTRATING DUCTAL CARCINOMA AT THE JUNCTION OF INNER-UPPER AND INNER-  LOWER QUADRANT. THE CANCER HAS A PREDOMINANTLY CRIBRIFORM PATTERN WITH AREAS OF COMEDO NECROSIS; SEE COMMENT. THE TUMOR MEASURES 2.5 CM IN GREATEST DIMENSION. NSABP NUCLEAR GRADE MODERATELY DIFFERENTIATED, HISTOLOGIC GRADE 2 OF 3. LOCAL TUMOR INVASION OF MAMMARY LYMPHATICS ADJACENT TO THE TUMOR IS IDENTIFIED. DEEP SURGICAL MARGINS FREE OF TUMOR. 2. INTRADUCTAL CARCINOMA, CRIBRIFORM TYPE, ADJACENT TO INFILTRATING CARCINOMA. 3. FOCAL ATYPICAL EPITHELIAL HYPERPLASIA IN THE UPPER-OUTER QUADRANT (BLOCK A11). 4. FLORID DUCTAL EPITHELIAL HYPERPLASIA OF THE USUAL TYPE, MILD TO FOCALLY FLORID. 5. REST OF BREAST WITH SCLEROSING ADENOSIS, MICROCALCIFICATIONS, BLUNT DUCT ADENOSIS, PAPILLARY APOCRINE METAPLASIA AND DUCT ECTASIA. 6. NO TUMOR IDENTIFIED IN 23 AXILLARY LYMPH NODES. OM : NH Verified by COMMENT : The histologic pattern of this carcinoma, is similar to the so-called cribriform ductal carcinoma. The nuclei of the cancer cells, however, are very pleomorphic and many mitoses are observed, and thus this carcinoma does not fit in the category of cribriform carcinoma as defined by Page et al. The. lesion may be better regarded as infiltrating breast carcinoma of no special. type because of the degree of atypia present. 2 of 2
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+TiDO3 UUID:4705E851-FE91-4FCF-94FC-4872A381DED4 Rpinelle eeQQ miLl 87xf3 S.te: Wveltact C69.4 Q/io[14 Enucleation of the left eye. Macroscopy: The eyeball measures 25 mm in diameter and the posterior optic nerve segment 7 mm. Tissue specimens have been taken for cryopreservation and then the piece has been fixed and included entirely. Su pah discrpecy fom fr Microscopye The eyeball presents a tumor exhibiting the morphology of an uveal melanoma. composed of fusiform (40%) and of epithelioid cells (60%). Important melanotic. pigmentation. The mitotic index is very low. There is no necrosis.. The tumor invades the ciliary body. The sclera, the optic nerve on its entire course, the meningeal sheath and the end cut of the optic nerve are free of tumor. There is no extrascleral extension. The tumor size is 12X7 mm main lines Conclusion: Uveal melanoma composed of fusiform and of epithelioid cells.. Tumor size: 12X7 mm Low mitotic index. Tumor extension of the ciliary body No extrascleral extension. Sclera, optic nerve in its entire course, cut end of the optic nerve and meningeal sheaths free of tumor..
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+V4.00 TCGA Pathologlc Diagnosis Discrepancy Form Instructlons: The TCGA Pathologic Diagnosis Discrepancy Form should be completed when the pathologic diagnosis documented on the initial pathology report for a case submitted for TCGA is inconsistent with the diagnosis provided on the Case Quality Control Form completed for the submitted case. Tissue Source Site (TsS): .... _ TSS Identifier: .  TSs Unique Patient Identifier: - Completed By (Interviewer Name on OpenClinica): --.. Completed Date: _ Diagnosis Information # Data Element Entry Alternatives Working Instructions 60% epithelioid cells Provide the diagnosis/histologic subtype(s) documented on Pathologic Diagnosis the initial pathology report for this case. If the histology for Provided on Initial this case is mixed, provide all listed subtypes. 40% spindle cells Pathology Report Histologic features of  Provide the histologic features selected on the TCGA Case 61-90% epitheliold cells Quality Control Form completed for this case. the sample provided for TCGA, as reflected 1-30% spindle cells  on the CQCF. Discrepancy between Pathology Report and Case Quality Control Form  Provide the reason for  Provide a reason describing why the diagnosis on the initial the discrepancy The section of the frozen sample used for sending  pathology report for this case is not consistent with the..  between the pathology to TCGA corresponds to a section of the tumor diagnosis selected on the TCGA Case Quality Control Form.  report and the TCGA where the epithelioid part is predominant..  Case Quality Control Form. The percentages mentioned on the initial  Pathology Report correspond to an average on the whole embedded sections used for establish the Pathology Report. Name of TSS Reviewing Provide the name of the pathologist who reviewed this case Pathologist or for TCGA. Biorepository Director I acknowledge that the above information provided by my institution is true and correct and has been quality controlled. TSS Reviewing Pathologist or Biorepository Director Date I acknowledge that the above information provided by my institution is true and correct and has been quality controlled. Ths Attending Pathologist or the Department Chairman has been informed or is aware of the above discrepancy in diagnoses. Principal Investigator Signature Date
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+UUID:A58D47E8-E889-4267-830A-6EE9782D28EC TCGA-2Y-A9GY-01A-PR Redacted Pathology Report Gender Service: Received: Peported IcQ03 Fatnolcgsatt Intraop ratnolegistt Perrormang,Physictans arenoms, dhepsteellulor NOS CILNICAL HISTORY: NONE GIVEN. 8170|3 FRECPERATIVE DIACNCSIS: Site: sLier Sx2O LIVER CANCKR SFECIMEN TYPE(SI 4I 4|28|14 A.GALLIADDER. Ar LIVER MARGIN FS C: RICHT LORK OF LIVER SECMENT S  6 FINAL DIAGNOSIS A. GALLBLADDRR CHOLECYSTECTOMY Chronic cnoiecyetttis. B. LIVER MARGIN L ver parenchyss with ateatoats. No evidencepr naligrancy- C RICHT LOK CF LIVER SEGXENT 5 AND RESRCTION: Hepatocellular cazcincma, multlrocal. see Key Patnctogica Findings Surgical.maryins,tree ot malignancy Patnoiogic stage: pT2 Nx MX. KEY PATHOLCGICAL FINDINGS rumor typer Hepatocezular carcinona.multirocal Tumor conriguration: Parttally encapguiated and noduar Tumor size: 5x75x5Qcm and0.8 sateilieumornodule H'stologie grade:  Poorly dixrerentiated rumor necxosig Identaried5 Extent of invaascn: Tumor'isconcirel to within liver. Ferineural invaaionr Not Icentiried. Parerchynal margant Free ot caligrancy Hile duet margin:. Not applicabie Venous:{large vessel) Anvasion: Identirled Maditional patnologic rtndinga: Severe areatcais. Noevidence or clrrhcais Lympn noaea Not appitcabie Patnologic stages pT2 NX MX This .caeewas revtewed prospectivelyat the the, attending pathologiat, peraonaliy reviewed the entire. patalojy csse ond rendered che rinsl lisgroata. xiectronicaxiy signed out by OTHER RELATED CLINICAL CATA
+
+--- Page 2 ---
+NA. INTRAOPERATIVE DIAGNOSIS: FsB: LIVER MARGIN FS Steatceie Negatiye ror tumor. INTRADEPARTMENTAL CCNSULTATION: coMMeNr This rrozen sectioa dsagrosts/reauit waa.c nunicated tc and acknowledged ny in C. BAGHT LOHE OF LIVER SAUMENT S  6. GRCSS EXAMINATION: numor presentcloaest sargin atD.a cn. nave pertormed tne intraoperatiye. consultatsona ans'isauei tne atove diagnoses. CROGS DESCRIPTION: A. Specimen A ia receiveu rrash Aateled *gallblaader." Tne specicen:consista.of galinladder whicn meaeures 9.0.x 3.o x.?.5:co. Tme serosa ot. the galibiadder 1s: Can-pink, smootn,. gliatening, The gal:rladder' contents corslat ot'a moderate amount. of viscous greenbile ng choieliths are grosay identltied. rnegabiadder wall 3Bures0. c n thicknegs an is.grcasly unrenarxabie. Tne mvcoga o the Jalibiadser is vaivety and, contains bi!e green. The cystic duct is patent to the. How ot nite 3n ns 3 cmin diameter lmen. No lypn nodea regrossly dantirsed saacent toyalibladder peck. No tlasue is submitted to tne Tisaue. Frocurement Larcrstory.Repreaentative.secticns or tne apecimen are aubmitteg in two cassettes Al argA. B. specimen  is recsived trest, labeieo *river sargin Iruie out bepatasa). The apecimen conaista or a single, irreguar uroriented Iragment'cr tan-red brown, aot-co-rubdery.tissue, measuring 0.x 0.5 x0.3.cm wnich 1.submittedentarely tor rrozen.sect:on aa rse. C. Specimenc.is recelved rresn, laseled*right. lobe liver,segments+6.* Tne apecimen consists ot sat grama.an irreguiar unorienteo rragment ot iiver parenchya.Tne specimen meseures 15.0x.i0.dx6.0 cn.re capsuleor liver1 razgin iagroasiy snrezarkable and inked black, Tnisspecimen is serislly secttored to cevea: in irragular to ovora ill-setined, rubbery, Intraparenctyn3l. Cumor Dut doea not appear cs exuena tnrougn. tne liver capauie. and witnin os e. or tre ciosest parescnycal xesectlon sargin whicn ia tnxed plackTne.cut surrace cr tne cusor is hemogerecua, tan-wnite to tan pinx, Iocaliy hezorrhagic. Alao tne cecond aateliice tumorncule is tdentiriedwichin the.tiver parenchya,.measuring.up D.a.cin greatest dimensien. Thse nodue 1s.4.0 cm.trom the clcsest parencnymal xeeectton argin. ne remaining Iiver parenctyma 1s grossly unremarkani. No tissue is submltted to tna Ttssue Procuremens Latoratory..Repreaentative secctons.bt tne Hpecimen submitted in 9 cassettes Cl-c9 1s rcllows CI-5 Repreaentative sectionsor tne closest to tusor parencnymal resection argin C6t Central. part. of tne tumor. C7 Gatellite intraparenchysal.tusor nodule COr. umor partially adjacent to capaule C9 Uninvoived iivar parencnyma. bw 1/2114
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diff --git a/output/text/5ce0bd35-fcdc-4fb1-bcd9-ed349b7000bc.txt b/output/text/5ce0bd35-fcdc-4fb1-bcd9-ed349b7000bc.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4eae731a18efd562d13229071a3d910c8b4de06d
--- /dev/null
+++ b/output/text/5ce0bd35-fcdc-4fb1-bcd9-ed349b7000bc.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+L0D03 Date of surgery : 877113 Left eye enucleation aih. Macroscopy QJ 3/io|14 The eye ball mesures 28 by 20 mm and presents a posterior segment of optic nerves. measuring 7 mm. At the section, the tumor measures 17 mm main line. Samples have been frozen for genetic studies then the piece has been fixed and included. entirely. Microcopy The tumor observed macroscopically corresponds to an uveal melanoma, mainly composed of epithelioid cells. The cell cytoplasm is often pigmented with melanin The nuclear atypia are severe. The mitotic index is low (4 mitoses for 10 HPF). The tumor is developed close to the ciliary body and infiltrates the internal part of the sclera, leaving the half external part free. It is located at a large distance of the optic foramen and the optic nerve on its entire course and cut end is free of tumor.. The meningeal sheets and the extra-scleral tissues are free of tumor.. Conclusion UUID:3EA19BCF-5CE1-4C19-9C21-BEE6D9E45C74 TCGA-V4-A9EM-01A-PR Redacted Uveal melanoma of the left eye Epithelioid cells predominant Size of the tumor: 17 mm. Infiltration of the internal half part of the sclera without extrascleral extension.. No intra-vascular tumor embolisms The optic nerve on its entire course, its cut end and the meningeal sheets are free of. tumor.
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diff --git a/output/text/5ce389c3-ed89-4dad-9b7d-24ab160422c0.txt b/output/text/5ce389c3-ed89-4dad-9b7d-24ab160422c0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3dbc0bb116ffab0c9840226d47b94d73206b1d1f
--- /dev/null
+++ b/output/text/5ce389c3-ed89-4dad-9b7d-24ab160422c0.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+ PREVINIIS DIAGNOSIS INQUIRY UUID:EAC92541-2274-4FB8-B568-657413EDF0F9 TCGA-OR-A5K9-01A-PR Redacted PAGE#: SEX:F  PAT TYPE: ADM DATE: OPER DATE: TeD-D-3 PROCEDURE: SPHS arcincino, adrenal Corticoj 8B7D13 'ear-old with history of adrenal mass and Cushing's syndrome per cr. No mets. Operative Procedure: Right adrenalectomy, right nephrectony, wedge Site: Atreral Ekndl resection of liver. Cortex C74.D )1/Q8/13 PROCEDURE: SPGD 1. "R. radical adrenalectomy." Received fresh is a 253 gram trimmed portion of ovoid possible adrenal tissue, 9.3 x 8.2 x 6.7 cm. The cut surface reveals a 9.8 x 7.3 x 6.0 cm hemorrhagic possibly necrotic tan tunor that abuts the margin. A scant amount of bright orange-yellow tissue is identified measuring. 3.7 x 1.3 x 0.8 cm. Attached to the periadrenal adipose is a 4.3 x 2.2 x 0.3 cm possible portion of liver. The cut surface is red-brown. Also attached to the periadrenal adipose is a 193 gram kidney, 11 x 6 x 4.2 cm. The cut surtace. of the kidney is a tan-brown with a well-defined corticomedullary junction. No. lesiors are noted. The adrenal gland is somewhat embedded within the kidney cortex. No other lesions are noted. 1A-I. Adrenal mass. 1J. Adrenal mass to possible liver. 1K. Kidney margins. 1L. Adrenal gland to kidney.. 1M. Ncrmal kidney. PROCEDURE: SPDX 1. Right adrenal and kidney, excision: Adrenal cartical-carcinoma(.8.cm), high-grade, adherent to, but not directly invading, the kidney and liver. Margins negative. Histologically unremarkable kidney. Case reviewed by the signing staff pathologist, have personally examined"and"interpretec lides from this case. ********************** ** END OF PREVIQUS DIAGNOSIS INQUIRY ** wJ 1/413
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diff --git a/output/text/5ced3152-1848-4a32-a3db-053bb981a498.txt b/output/text/5ced3152-1848-4a32-a3db-053bb981a498.txt
new file mode 100644
index 0000000000000000000000000000000000000000..83cf84a7639c441a7dfa2f3baed13fe85ebf4234
--- /dev/null
+++ b/output/text/5ced3152-1848-4a32-a3db-053bb981a498.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:E9A88ESB-4F50-4683-9C65-56CFCB15405E TCGA-GM-A3XN-01A-PR Redacted DIAGNOSIS (A) LEFT BREAST, SEGMENTAL MASTECTOMY: INVASIVE LOBULAR CARCINOMA OF THE BREAST, MODIFIED BLACK'S NUCLEAR GRADE 1 AND 2 (LOW AND INTERMEDIATE GRADE), PRESENT AS THREE MASSES MEASURING 2.0 CM, 1.9CM AND 1.1 CM IN  MAXIMUM DIMENSION. (SEE COMMENT) PERINEURAL INVASION IS IDENTIFIED. INVASIVE TUMOR IS NOTED WITHIN 0.1 CM FROM THE MEDIAL MARGIN, 1 MM AND 2 MM FROM THE DEEP AND ANTERIOR MARGINS TOWARDS THE MEDIAL END OF THE SPECIMEN. LOBULAR CARCINOMA IN SITU (LCIS), MODIFIED BLACK'S NUCLEAR GRADE 1 AND 2 (LOW AND INTERMEDIATE GRADE), WIDELY DISPERSED. Reactive changes at previous biopsy site. Fibrocystic changes. METASTATIC ADENOCARCINOMA INVOLVING ONE OF ONE SENTINEL LYMPH NODE (1/1) MAXIMUM SIZE OF METASTASIS IS O.3 CM. Extranodal extension is not identified. (B) PALPABLE LYMPH NODE, LEFT AXILLA: METASTATIC ADENOCARCINOMA IN ONE OF ONE LYMPH NODE (1/1). MAXIMUM SIZE OF METASTASIS IS 0.9 CM. EXTRANODAL EXTENSION IS PRESENT, MEASURING O.1 CM IN MAXIMUM DIMENSION. (C) SECOND PALPABLE LYMPH NODE: One lymph node, no tumor present (0/1). (D) ADDITIONAL DEEP MARGIN: Fibroadipose tissue and skeletal muscle, no tumor present  (E) 4EFT AXILLARY CONTENTS: METASTATIC ADENOCARCINOMA IN THREE OF THIRTY-ONE LYMPH NODES (3/31) MAXIMUM SIZE OF METASTASIS IS 0.4CM. EXTRANODAL EXTENSION IS PRESENT, MEASURING O.5MM IN MAXIMUM DIMENSION (F)LEFT BREAST, NEW ANTERIOR MARGIN, EXCISION: No evidence of invasive carcinoma. LOBULAR CARCINOMA IN SITU (LCIS), IN FEW FOCI. Columnar alteration and ductal epithelial hyperplasia without atypia... (G) LEFT BREAST, NEW ANTERIOR MEDIAL MARGIN, EXCISION: No evidence of malignancy. iD o-3 carcinoma, inF1nah ng lobwar,NOS 8s20J3 COMMENT Si+. br<aof,N0s c5.9 5-Z3-iZ eD The invasive lobular carcinoma demonstrates tubule formation in occasional small foci comprising much less than 1 % of the. entire tumor. Few signet ring cells are noted in both the in situ and invasive tumor.. GROSS DESCRIPTION (A) FOR IMMEDIATE INTRAOPERATIVE CONSULTATION AND X-RAY IMAGING LABELED LEFT SEGMENTAL MASTECTQMY, SHORT STITCH SUPERIOR, LONG STITCH LATERAL, PURPLE iS DEEP - A breast tissue with needle localization wires measuring 10.0 x 6.0 x 5.0 cm. Surgical margins are inked. The specimen is radiographed before and after slicing and the radiograph is reviewed by the radiologist. The specimen is sectioned from lateral to medial aspect into seven slices. Slice 3 contains an ill-defined, firm tan lesion #1 containing radiological clip. It measures 1.1 x 1.0 x 0.6 cm. It is more than 1.0 cm from all the margins. Cut surface of slices 4 and 5 contains a second ill-defined indurated tan lesion with clip measuring 2.0 x 1.2 x 1.1 cm. It is 0.4 cm from the closest anterior surgical margin. Cut surface of slice 5 and 6 shows an ill-defined lesion 3. with clip measuring 1.9 x 1.6 x 1.3 cm. In slice 5, lesion 3 and 2 are grossly connected to each other. Lesion 3 is 0.5 cm away. from the medial surgical margin, 0.2cm from deep margin and more than 1.0 cm from the rest of the margins. Located in fatty. tissue at the inferior aspect of slices 1 and 2 are two possible lymph nodes ranging from 1.1 up to 1.3 cm in greatest dimension which are indicated by the surgeon to represent the sentinel lymph nodes. Lymph nodes identified in slice 1 is sent for protocol Representative sections are submitted. A portion of the tumor is given to tumor bank. INK CODE: Superior - blue; inferior - green; anterior - yellow; posterior - black; lateral and medial -red. SECTION CODE: A1, possible lymph submitted for protocol identified in slice 1; A2, A3, slice 3, lesion 1, mirror images; A4. slice 3. tissue sunerior to lesion 1 includinn sunerior curnical marnin. A6 etico a ticeun nasta.
+
+--- Page 2 ---
+posterior surgical margin; A7, slice 2, tissue laterally to lesion 1; A8, slice 5, lesion 2 in relation to the anterior surgical margin; A9, slice 4, lesion 2; A10, slice 4, anterior surgical margin; A11, A12, slice 5, mirror images of lesions 2 and 3 in relation to each; A13, slice 5, inferior surgical margin; A14, slice 5, superior surgical margin; A15, slice 5, posterior surgical margin; A16, slice 6, possible continuation of lesion 2 in relation to the anterior surgical margin; A17, A18, slice 6, mirror images of lesion 3 in relation to. the deep surgical margin; A19, slice 6, tissue inferior to A16, including anterior surgical margin; A20, A21, lesion 3 in relation to the medial surgical margin; A22, slice 2, sectioned possible lymph node.. (B) PALPABLE NODE, LEFT AXILLA FOR FS - A single possible lymph node measuring 1.8 cm in its areatest dimension. Possible lymph node is sectioned and entirely submitted for frozen section in cassettes B1 and B2. (C SECOND PALPABLE LYMPH NODE - A single fatty possible lymph node measuring 2.5 cm in its greatest dimension. Possible lymph node is sectioned and entirely submitted for routine Histoloav. SECTION CODE: C1-C3, one sectioned possible lymph node. (D) ADDITIONAL DEEP MARGIN, iNK ON TRUE MARGIN - A single fragment of a fatty tissue with ink indicating true measuring 4.5 x 3.5 x 1.1 cm. Cut surface is fibrofatty. Entirely submitted.. INK CODE: True surgical margin - blue.. SECTION CODE: D1-D7, entire tissue. (E) LEFT AX!LLARY CONTENTS - A single fragment of a fatty tissue measuring 8.0 x 7.0 x 3.0 cm. Dissection reveals multiple possible lymph nodes ranging from 0.3 up to 1.8 cm in greatest dimension. Possible lymph nodes are entirely. SECTION CODE: E1, five possible lymph nodes; E2, five possible lymph nodes; E3, five possible lymph nodes; E4, five possible lymph nodes; E5, two possible lymph nodes; E6, one sectioned possible lymph node; E7, one sectioned possible lymph node; E8, one sectioned possible lymph node; E9, one sectioned possible lymph node; E10, one sectioned possible lymph node; E11, one sectioned possible lymph node; E12, one sectioned possible lymph node; E13, one sectioned possible lymph node; E14 one sectioned possible lymph node; E15, one sectioned possible lymph node: E16, one sectioned possible lymph node; E17, one sectioned possible lymph node; E18, one sectioned possible lymph node.. (F) NEW ANTERIOR MARGIN, INK ON TRUE MARGIN - A single fragment of a fibrofatty tissue with ink indicating true margin measuring 3.6 x 3.2 x 1.8 cm. True surgical margin is reinked blue. Cut surface is fibrofatty. Entirely submitted. SECTION CODE: Entirely submitted in cassettes F1-F8. (G) NEW ANTERIOR MEDIAL MARGIN, INK ON TRUE MARGIN - A single tragment of a fibrofatty tissue with ink indicating true margin measuring 4.0 x 3.0 x 0.9 cm. The surgical margin is reinked blue. Sectioned and entirely submitted. INK CODE: True surgical margin - blue. SECTION CODE: G1-G6, entire tissue. CLINICAL HISTORY None given. SNOMED CODES T-04050, T-C4710, M-85203, M-85206, M-85202 "Some tests reported here may have been developed and performance characteristics determined by ! These tests have not been specifically cleared or approved by the U.S. Food and Drug Administration." ---EnD Of repOrt----
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diff --git a/output/text/5d32e519-e358-4537-b9aa-045105032555.txt b/output/text/5d32e519-e358-4537-b9aa-045105032555.txt
new file mode 100644
index 0000000000000000000000000000000000000000..007b596da897614892feb717238685a0d17a52de
--- /dev/null
+++ b/output/text/5d32e519-e358-4537-b9aa-045105032555.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Final Pathologic Diagnosis: Kidney, right, radical nephrectomy:. Tumor histologic type: Papillary renal cell carcinoma, type1 Sarcomatoid features (%): No Tumor size: greatest dimension 3.5 cm (mass overlying psoas muscle) Other dimensions: 3.0 x Macroscopic extent of tumor: Tumor is perinephric fat, no gross involvement of renal parenchyma Focality: (unifocal/multifocal) Multifocal (all in perinephric. soft tissue) If multifocal, number of tumors Four discrete soft tissue masses (see Note) Fuhrman grade: 3 of 4 Perinephric fat invasion: (yes/no) Yes (See Note) Renal sinus invasion: (yes/no) No Renal vein involvement: (yes/no) No Adrenal gland present: (yes/no) No Cancer at resection margin: (yes/no)  No Pathologic findings in nonneoplastic kidney:. Interpolar scar, consistent with history of laparoscopic partial nephrectomy, 2.5 x 1.5 x 1.5 cm. Papillary adenoma (1 mm) Renal cortical cyst in inferior pole, 0.5 cm.. Lymph nodes present:(yes/no) Yes If yes, number involved/number present:. 2/2, with extracapsular extension Pathologic stage rpT4, pN1, pM (not applicable) (See Note). The examination of this case material and the preparation of this report were performed by the staff pathologist. Note: Sections of the perirenal fat and psoas muscle nodules show papillary adenocarcinoma, consistent with type 1 papillary renal cell carcinoma. We interpret these nodules as recurrent tumor from the patient' s original renal cell carcinoma that arose from reported seeding during the prior laparoscopic partial nephrectomy (pathology material from that procedure is not available for review). The tumor adjacent to the kidney is associated with old scarring and fibrosis likely related to the prior surgical procedure. There is no tumor in the renal parenchymal scar. There is focal invasion of the psoas muscle by the
+
+--- Page 2 ---
+tumor and so the local pathologic stage is considered rpT4. A small Iymph node with metastatic papillary adenocarcinoma is seen adjacent to the psoas mass. Histologic sections of the unattached mass show a lymph node with metastatic papillary adenocarcinoma. Both nodes show extracapsular extension of the tumor. The dimensions of the tumor nodules in the perirenal fat are: Posterior-superior-medial 2.5 x 2.0 x 1.3 cm. Psoas 3.5 x 3.0 x 2.0 cm. Posterior-inferior-lateral 1.1 cm in greatest dimension. Posterior-interpolar-lateral 1.4 cm in greatest dimension. Gross Description:. The specimen is received in a container of formalin, labeled with the patient's name and "right radical nephrectomy." It consists of a kidney and surrounding perinephric fat, measuring 16 x 10 x 6.5 cm. An additional portion of adipose tissue accompanies the kidney, measuring 10.5 x 8.0 x 1.5 cm. Prior to receipt in the histology suite, the external surface of the kidney was inked with black ink. The posterior aspect of the kidney was previously sectioned in a coronal plane. A portion of a mass in the posterior-medial-superior perinephric fat was banked for future research. A portion of ureter measuring 10 cm in length by 0.3 cm in diameter is attached to the kidney. The ureter is probe patent. Short segments of the renal artery and vein protrude from the specimen. The renal vein is patent and free of thrombus. The renal artery is patent and free of thrombus. A globular, firm, tan, homogeneous mass traversed by fibrous septae is present in the perinephric fat, posterior-medial-superior to the kidney, measuring 2.5 x 2.0 x 1.3 cm. A portion of this mass was previously harvested for research. The surface of the mass abuts the resection margin, but does not appear to penetrate the resection margin. The mass compresses, but does not appear to invade the renal cortex. A portion of psoas muscle is present on the posterior/inferior aspect of the specimen, measuring 4.0 x 2.5 x 0.6 cm. The psoas overlies a globular, firm, tan homogeneous mass traversed by fibrous septae, measuring 3.5 x 3.0 x 2.0 cm. The mass appears to invade the psoas muscle though it does not penetrate to the resection margin. A third firm tan mass is found in the inferior-posterior-lateral pararenal fat, measuring 1.1 cm in greatest dimension. It abuts the surgical resection margin. A fourth firm tan mass is found in the posterior-lateral-interpolar pararenal fat, measuring 1.4 cm in greatest dimension. It abuts, but does not penetrate the renal capsule. It abuts the surgical resection margin. Sections of the kidney show a scar in the interpolar region, measuring 2.5 x 1.5 x 1.5 cm. A few surgical clips are embedded in the scar. A thin walled cyst is present in the inferior pole of the kidney, measuring O.5 cm in diameter. The unattached fat is sectioned. No lesions are seen. No adrenal gland is present. A firm tan nodule with a smooth surface that is unattached to any of the other tissue fragments is present, measuring 1.2 x 1.1 x 0.7 cm. The hilar fat is soaked in Carnoy' s fixative and then dissected for lymph nodes.
+
+--- Page 3 ---
+The following sections are submitted:. 1 renal artery, renal vein and ureter margins; 2 additional ureter; 3 posterior-superior-medial mass to margin;. 4 posterior-superior-medial mass to kidney; 5 psoas mass; 6 psoas mass; 7 posterior-inferior-lateral mass;. 8 posterior-interpolar-lateral mass;. 9 renal scar; 10 renal cyst; 11 representative kidney; 12 unattached mass; 13 possible hilar lymph nodes.. Microscopic Description: The final diagnosis of each specimen incorporates the microscopic examination findings. Taken END OF REPORT
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diff --git a/output/text/5d4a1994-dca5-4a7e-9d6c-28ef8ca6a81c.txt b/output/text/5d4a1994-dca5-4a7e-9d6c-28ef8ca6a81c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4b790a833c263f7339c4510889d08e6dae725c09
--- /dev/null
+++ b/output/text/5d4a1994-dca5-4a7e-9d6c-28ef8ca6a81c.txt
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+
+--- Page 1 ---
+Final Received Date/Time Final Reporting Information Date/Time : Histopathologist : Laboratory : Final Consultant-In-Charge Final Submitting Physician Final Histopathology Report DIAGNOSIS LEFT LEVEL 2 CERVICAL LYMPH NODE; EXCISION: DIFFUSE LARGE B-CELL LYMPHOMA. GROSS DESCRIPTION Received a piece of specimen measuring 2 x 1 x 0.5cm which is trisected. One piece measuring 1 x 0.5 x 0.2cm is partitioned for snap-freezing.. Received subsequently in formalin, labelled with patient's data, and designated "cervical lymph node" are fragments of soft tissue altogether measuring 1.5 x 1.5 x 0.8cm, submitted entirely. (A1 & A2; no reserve) MICROSCOPIC DESCRIPTION The nodal architecture is diffusely effaced, with spillover into extranodal adipose tissue, by patternless masses of medium-sized cells with ample, pale eosinophilic cytoplasm and irregular, vesicular nuclei containing dispersed chromatin that allows visualisation of one-to-several nucleoli, accompanied by scattered mitoses and apoptotic debris, the latter within tingible-body macrophages that focally impart a "starry-sky" pattern. No granulomas or metastatic malignancy is seen. The.lymphomatous proliferation is strongly and diffusely positive for pan-B cell. marker cd20 and coexpresses late-to-postgerminal centre-associated Mum.1 with germinal centre-associated bcl-6, as well as antiapoptosis protein bcl-2 to far greater extent than can be accounted for by physiological expression in the small numbers of admixed, cD3-positive, reactive, small T-lymphocytes, while being largely negative for germinal centre-associated antigen cpio, which. highlights background stroma, thereby excluding Burkitt lymphoma in conjunction with a. variable cell proliferation fraction that falls well short of 100%,. culminating around 70-80% by Ki-67 immunolabelling. Immunostaining for Cyclin D1 is negative within the lymphoid proliferation, highlighting only physiological expression in scattered histiocytic and activated endothelial nuclei, excluding a blastoid mantle cell lymphoma. Negativity for terminal deoxynucleotidyl transferase, except in rare haematogones, rules out a precursor lymphoblastic. neoplasm in conjunction with the cD10-negativity. cd2l-immunoreactive follicular dendritic meshworks are rare, peripheralised and markedly attenuated, in keeping with being overrun rather than supporting a folliculocentric component. External positive controls are in working order. (For your attention)
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diff --git a/output/text/5d92acc1-08b4-4bd9-bac0-955b5f8527c1.txt b/output/text/5d92acc1-08b4-4bd9-bac0-955b5f8527c1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4e251fdcd19c584bcf8d46f8ed0f47684cc949f2
--- /dev/null
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+--- Page 1 ---
+Result Type: Surgical Pathology Report LCDD-3 Result Date: Performed By: areerons, yapillory renal 836o f3 Encounter info: ceSQ Surgical Pathology Report JJ 8/9/13 Surgical Pathology Report Reguested By: DIAGNOSIS: A. Right kidney, partial resection for tumor: pteee  Ranal cell carcinoma, papillary type. See synoptic report below: Synoptic Report: P Procedure/laterality:  Right kidney, partial nephrectomy. Histologic type:.  Papillary renal cell carcinoma.. Nuclear grade (Fuhrnan, 1-4): 3. Tumor size: 3 x 2.5  2.5 cm. Tumor site: Right kidney. Tumor focality: Unifocal. Sarcomatoid features: Absent.. Tumor necrosis: Absent. Microscopic tumor extension:.. Tumor does not extend through the renal capsule or involve perinephric tissue. Surgical margins:  Negative for cumor (sample received disrupted but inked margin sections ars negative for tumor). Lymph-vascular invasion: Not identified. :. Lymph nodes: Not applicable. Pathologic findings in nonneoplastic kidney: Kidney showing nondiagnostic findings. Pathologic staging: INM: pIla; pNX. Biorepository sampl. (if applicable):. A4; Centains 2 tissus Samples: One is loot normai kidney. The second fragments is tumor. (>90t of nucleated cells). A2 Kert CLINICAL INFORMATION: Right renal mass. PA SPECIMEN(S): A:Right renal mass GROSS DESCRIPTION: Performed by A. Received fresh labeled "right renal overall specimen dimensions are 5.5 x 4 x 3.5 cm. The portion of kidney is 3.5 x 3 x 3 . Bulging from the parenchymal margia is a friabie yellow-tan mass, 3 x 2.5 x 2.5 cm in maximum dimension. The mass does not grossly axtend through the overlying renal capsule. The renal capsule is"inked black. The parenchymal margin surrounding .ninn msas is inked blue. Sampled in four cassettes labaled nked capsular surface and tumor; A2) inked parenchymal margin witn adjacent bulging tumor; A3) sample of fat overlying renal cananie: a4) mirror images of sample submitted for research Support for the diagnosis in this case may have included the use of immunohistochemistry tests that were develnned and whose Pharacteristics were determined by. Derfava- They have not oeen creared Or approved by the U.s. Fooa ana urug Administration (FDA). The FDA has determined that such clearance or approval is not necessary. These tests should not be regarded as investigational or for research. : This laboratory is certified under tha Clinical Laboratory Improvement Amendnents of 198s ('CLIA') as qualified to perform high complexity clinical laboratory testing..
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diff --git a/output/text/5da65a27-6478-48d2-96a2-13922a2669af.txt b/output/text/5da65a27-6478-48d2-96a2-13922a2669af.txt
new file mode 100644
index 0000000000000000000000000000000000000000..dbe5f5b7f5bac80cf39630310fe99b8841b2c611
--- /dev/null
+++ b/output/text/5da65a27-6478-48d2-96a2-13922a2669af.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis: 1. and 3.: resected section of colon (descending and sigmoid colon) with tumor-free oral and aboral resection margins and including an ulcerated, moderately differentiated adenocarcinoma with infiltration of the lamina muscularis propria, with several regional lymph node metastases (G2, pT2 L1 V0 R0 pN2a 5/31) and with distinctive, florid. perifocal inflammation (3.), encroaching on the peritoneum of the abdominal wall (1.).
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diff --git a/output/text/5dd5d8fb-a57b-4a2a-86ab-40185d3d4c2e.txt b/output/text/5dd5d8fb-a57b-4a2a-86ab-40185d3d4c2e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7479df374faf8214442399e22f59c967558e8578
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Page I of 3 Patient Name MRN Visit Number Event Date and Time Procedure Ordered Status |Ordered By Specimen # Surgical Pathology Report complete Collection Datey Accession Das Result Date. Copath# Surgical Pathology Consultation Report SPECIMEN(S) RECEIVED 1. Oral-Cavity: medial margin palate 2. Oral-Cavity: right partial maxillectomy 3. Oral Cavity: Right partial glossectomy- stitch anterior margin 4. Oral Cavity: Deep margin tongue. DIAGNOSIS I. Medial palate margin:  Negative for tumour. 2. Right partial maxillectomy: Squamous cell carcinoma, well differentiated. t. The maximum dimension of the tumour is-1.3 cm. 3. The maximum thickness of the tumour is 0.5 cm. :. No iymphovascular or perineural invasion identified 1. Bone and bone margins are negative for tumour. :. All other margins are negative for tumour 3. Right partial glossectomy:  Squamous cell carcinoma in-situ (CIS), focally suspicious for superficial nvasion. t. Maximum Iesional dimension 0.6 cm. ,. Maximum lesional thickness 0.1 cm. :. All margins are negative for tumour (see comment) I. Deep margin of tongue. Negative for tumour. JYNOPTIC DATA Specimen Type: Resection:Right partial maxillectomy. Tumor Site: Oral Cavity Iistologic Type: Squamous cell carcinoma, conventional Tumor Size: Greatest dimension: 1.3 cm
+
+--- Page 2 ---
+Page 2 of 3 Tumor thickness: 0.5 cm Histologic Grade: G1: Well differentiated. Venous/Lymphatic (Large/Small Vessel) Invasion (V/L): Absent. Perineural Invasion: Absent Margins: Margins uninvolved by tumor Pathologic Staging (pTNM): pT1: Tumor of lip or oraI cavity 2 cm or less in greatest dimension -pNX: Regional-lymph nodes cannot be assessed for aerodigestive sites pMX: Distant metastasis cannot be assessed COMMENT 3. The "tumour" arising on the right tongue shows squamous cell carcinoma in-situ (CIS), at least. Focally the lesion shows ulceration and within this. area there is a focus suspicious for superficial invasion. It appears to be arising in a "field-effect" of abnormal squamous mucosa that shows keratosis  and varies gradually from minimal/mild'atypia to moderate dysplasia. While the  margins are negative for overt dysplasia, they do not appear entirely normal.. ELECTRONICALLY VERIFIED BY CLINICAL HISTORY Oral ca GROSS DESCRIPTION 1. The specimen is labeled with the patient's name and as "mediaI margin palate". It consists of 3 bony fragments of tissue measuring 0.2 x 0.1 x 0.1 to 0.3 x 0.2 x 0.1 cm. The specimen is submitted in toto.. 1A medial margin palate 2. The specimen is labeled with the patient's name and as right partial maxillectomy. It consists of upper right jaw measuring 4.5AP x 1.8 SI x 2ML cm. It includes a portion of maxilla with 2 teeth. There is a tumor arising in the alveolar ridge. The tumor measures 1.3 AP x 0.5 SI x 1.2 ML cm. The tumor is raised and partly hemorrhagic. There is no involvement of bone by the. tumour. The tumor is located at 0.2 cm from the closest medial mucosal margin. Remaining margins are as follows: lateral mucosa margin 0.6cm; 1.5cm from posterior mucosal margin; 0.7cm anterior mucosal margin. The lateral margin is painted with green dye and the medial India ink. Representative sections are submitted. 2A medial mucosal margin 2B lateral mucosal margin 2C anterior mucosal margin
+
+--- Page 3 ---
+Page 3 of 3 2D posterior mucosal margin 2E-2G tumor 2H anterior maxilla margin, in decal 2I posterior maxilla margin, decal 2J mid section through bone, decal 3. The specimen is Iabeled the patient's name and as "right partial glossectomy stitch anterior margin". It consists of a portion of right ventral tongue. measuring 2.8 SI x 1.1 ML x 3.1 AP cm. There is a suture orientation. There is a superficial ulcerated tumor involving the lateraI surface of the tongue. The tumor measures 0.5 SI x 0.1 ML x 0.6 AP cm. It is located at 1.0 cm from the medial margin, 1 cm from the anterior margin, and 1.5 from the posterior. margin; 1.1 cm from the inferior mucosal margin. The remaining tongue mucosa. shows white plaques at 0.9 cm from the anterior edge of the tumor. These plaques measure 0.6 x 0.2 cm in aggregate. Representative sections are submitted. 3A anterior margin. 3B superior margin. 3C inferior margin 3D posterior margin 3E medial margin 3F-3G tumor in toto 3H plaque 4. The specimen is labeled with the patient's name and as "deep margin. tongue". It consists of a fragment of tissue measuring 0.9 x 0.8 x 0.4 cm. The specimen is submitted in toto for frozen section. 4A deep margin tongue.
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diff --git a/output/text/5e0e757b-b37d-4b71-8069-09cbbb61bfa4.txt b/output/text/5e0e757b-b37d-4b71-8069-09cbbb61bfa4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..69d41a0c415376930fb83ea26d842eba5613627f
--- /dev/null
+++ b/output/text/5e0e757b-b37d-4b71-8069-09cbbb61bfa4.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID: BC211027-32C2-4E6B-BEF6-980407966A1E Redacted Gross Description: A."Hepatic artery lymph node." A 2.0 cm lymph node is sectioned and no obvious metastatic nodules are identified. Half of the lymph node is processed for frozen section interpretation in 1 cassette, along with touch preps for rapid H and E interpretation. Microscopic Description: Specimen: Head of pancres, duodenum, stomach, common bile duct Procedure: Pancreaticoduodenectomy (Whipple resection) Tumor location: head Tumor size: 4.5 cm Histologic type: Ductal adenocarcinoma Histologic grade: Well differentiated Microscopic tumor extension: Invades peripancreatic soft tissue Surgical margins:. 1c0-0 -3 Distal pancreas margin: free. idanscacnmma,ducf 85o0f5 Sit:paucuns hsd cs5.0 Common bile duct margin: free pw Duodenum margin: free 1015/12 Retroperitoneal margin (Uncinate groove): free Angiolymphatic invasion: Absent. Perineural invasion: Present Treatment effect: No prior treatment Lymph nodes: Hepatic artery (A): 1 lymph node-negative for metastasis (0/1) Portal (B): 1 lymph node negative for metastasis (0/1) Peripancreatic, superior: 14 lymph nodes negative for metastases (0/14) Peripancreatic, inferior: 1 of 9 lymph nodes contain metastasis (1/9) Pancreaticoduodenal, anterior:. 6 lymph nodes negative for metastases (0/6)
+
+--- Page 2 ---
+Pancreaticoduodenal, posterior:. 15 lymph nodes negative for metastases (0/15) TNM-staging: pT3 pN1 pMx AJCC stage: IIB Diagnosis Details: Pancreas (Head): Adenocarcinoma invading into peripancreatic adipose tissue with a lymph node metastasis (1/46) Comments: Frozen section diagnosis A. Lymph node (Hepatic artery): Benign B.Lymph node (Portal): Benign. C. Pancreas duct margin: Negative for malignancy. Formatted Path Reports: PANCREAS TISSUE CHECKLIST Specimen type: Whipple resection Tumor site: Head Tumor size: 4.5 cm Histologic type: Adenocarcinoma, ductal Histologic grade: Well differentiated Tumor extent: Other - Peripancreatic soft tissue. Lymph nodes: 1/46 positive for metastasis (Hepatic artery, portal, superior peripancreatic, i 1/46) Lymphatic invasion: Absent. Venous invasion: Present Margins: Uninvolved Evidence of neo-adjuvant treatment: No Additional pathologic findings: Pancreas (Head): Adenocarcinoma invading into peripancreatic adipose tissue with a lymph node metastasis (1/46) Comments: Frozen section diagnosis, A. Lymph node (Hepatic artery): Benign, B.Lymph node (Portal): Benign C. Pancreas duct margin: Negative for malignancy.
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diff --git a/output/text/5e1abfd4-6fa8-4a75-9773-0fa348edcbf2.txt b/output/text/5e1abfd4-6fa8-4a75-9773-0fa348edcbf2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..44375513baa5a5d8bc1537dc3139a40ef61f25e6
--- /dev/null
+++ b/output/text/5e1abfd4-6fa8-4a75-9773-0fa348edcbf2.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+ UUID:0118D9AE-B923-4EEF-B8BC-82D559763FF9 TCGA-A2-A4S0-01A-PR Redacted Name Age/Sex: 17E: Location: Acct#; Unit#: StatusDISIN Room/Bed Reg: Disch: Att Dr: M.D Specimen: Received: Status: Req# : Collected: Sp type: SURGICAL P Subm Dr: M.D. PREOPERATIVE DIAGNOSIS 1co-0-3 8480/3 cArenomr, mvei`nns BREAST CA SM' brast Nos c5o.9 OPERATION PERECRMED 10(24/1) DATE : DOCTOR(S) : PROCEDURE :  TOTAL MASTECTOMY; EXCISION OF AXILLARY SENTINEL NODES A. RIGHT BREAST STITCH AT 12 O'CLOCK B. RIGHT SENTINEL NODE #1 ..GROSS DESCRIPTION RECEIVED IN 2 PARTS. RECEIVED LABELED RIGHT BREAST STITCH AT 12 O'CLOCK IS A A 2O41 SIMPLE MASTECTOMY MEASURING 33.5 CM FROM MEDIAL TO LATERAL, 28 CM FROM SUPERIOR TO INFERIOR, AND UP TO 5.5 CM FROM ANTERIOR TO POSTERIOR. THE NIPPLE IS INVERTED WITHIN A 3I X 17 CM SKIN ELLIPSE. A SUTURE DENOTES 12 O'CLOCK.  4 CM LATERAL TO THE NIPPLE AT 9 O'CLOCK IS A LOBULATED RED-TAN GLISTENING MASS MEASURING 2.2 CM FROM SUPERIOR TO INFERIOR, 2 CM FROM ANTERIOR TO POSTERIOR, AND 4.5 CM FROM MEDIAL TO LATERAL. THIS LESION IS 2.5 CM FROM THE DEEP MARGIN. TOWARDS THE LATERAL EDGE THERE IS A 2ND NODULE ADJACENT BY LESS THAN 1 CM MEASURINGS 1 X 1 X 1 CM.  THERE IS A RIBBON CLIP ASSOCIATED WITH THIS AREA. THE REMAINING BREAST TISSUE CONSISTS OF BLAND YELLOW FATTY TISSUE WITH FINE FIBROUS BANDS. A WING CLIP IS IDENTIFIED IN THE LARGER LESION. REPRESENTATIVE SECTIONS ARE SUBMITTED AS FOLLOWS:  A1--NIPPLE, A2--DEEP MARGIN TO LARGER LESION, A3--THE MOST LATERAL PORTION OF THE LARGER LESION, A4---THE MOST MEDIAL PORTION OF THE LARGER LESION 4.5 CM FROM A3, A5 THROUGH A7--ADDITIONAL SECTIONS OF LARGER LESION, A8 AND 9--SMALLER SUPERIOR RIBBON CLIP LESION, AIO--UPPER INNER QUADRANT 1O CM FROM THE LESION, A11--UPPER OUTER QUADRANT 4 CM FROM LESION, A12--LOWER OUTER QUADRANT 4 CM FROM LESION, A13-~LOWER INNER QUADRANT 1O CM FROM LESION. TISSUE IS TAKEN PER CLINICAL BREAST CARE PROJECT RESEARCH PROTOCOL OF THE LARGER LESION LABELED P1-P5 WITH FROZEN OCT SAMPLES AS MIRROR IMAGES TO P1 AND P2. IN ADDITION A MIRROR IMAGE SECTION OF THE NIPPLE (A1) IS SUBMITTED FROZEN IN OCT ALONG WITH THE 4 RANDOM QUADRANT SECTIONS
+
+--- Page 2 ---
+Patient: (Continued) Req#: Specimen: Received: Status: Collected: Sp type: SURGICAL P Subm Dr D. GROSS.DESCRIPTICN (Continued) A10-A13. B RECEIVED LABELED RIGHT SENTINEL NODE #1 HOT AND BLUE COUNT 39252 IS A PORTION OF PINK-TAN TISSUE WITH BLUE COLORATION MEASURING 1.3 X 0.8 X 0.4 CM. THE SPECIMEN IS BISECTED AND SUBMITTED LABELED.B. COMMENT :  THIS CASE EXCEEDS THE MAXIMUM CAP/ASCO GUIDELINE OF 48 HOURS FORMALIN FIXATION PATH PROCEDURES PROCEDURES: 88307/2, IMMUNOPEROXIDAS, A BLK/13, BBX X6 FINAL DIAGNOSIS PART A RIGHT BREAST, SIMPLE MASTECTOMY: MacwouCA |i7y 1. INVASIVE MUCINOUS CARCINOMAS (2) GRADE I WITH NUCLEAR GRADE 1 AND x2 LOW MITOTIC INDEX. 4.5  1cm 2. THE TUMORS MEASURE 4.5 AND 1.0 CM IN GREATEST DIMENSION. THE NIPPLE AND DEEP MARGIN ARE FREE OF NEOPLASM. margcus O Lv i 3. LYMPHATIC INVASION IS NOT IDENTIFIED. Bx c 4. BIOPSY SITE CHANGES WITH CLIPS PRESENT. 5. PROLIFERATIVE FIBROCYSTIC DISEASE WITH CALCIFICATIONS PRESENT. PART B RIGHT SENTINEL NODE 1: LYMPH NODE (1), NEGATIVE FOR TUMOR BY STEP SECTION AND CYTOKERATIN STAIN. Signed Electronically signed by:.. M.D. Jualy's
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diff --git a/output/text/5e5f5858-1d0f-4724-a307-12ee149f2b79.txt b/output/text/5e5f5858-1d0f-4724-a307-12ee149f2b79.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b6a9c0870222475be223a9b7e37a7e53053cf4cc
--- /dev/null
+++ b/output/text/5e5f5858-1d0f-4724-a307-12ee149f2b79.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Sample Number Sample Type  TUMOUR Diagnosis  PAPILLARY RENAL CELL CARCINOMA TYPE I Year of Sample Collection Age at Sample Collection (yrs).  Days to Procedure Date  Days to Diagnosis Type of Procedure  RESECT Site of Tissue/Primary (Histology).  RIGHT PARTIAL KIDNEY Tumour Size (cm) 3.5  Histology  PAPILLARY RENAL CELL CARCINOMA TYPE I Grade/Differentiation 11  Pathological T T1a Pathological N NX  Clinical M  MO  Histology Comments Sample Number Sample Type BUFFY  Year of Sample Collection Age at Sample Collection (yrs)  Days to Procedure Date  Days to Diagnosis  UUID:9780BE36-91DE-4A1F-A940-737C731BDCECE TCGA-HE-A5NL-01A-PR Redacted tcdo-3 Carcinoma, papillary rens) cell Si+e:RKdney NOS Co4.9 8Q60/3 Sx/n/13 hs a/7/13 Criteria
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diff --git a/output/text/5e7648bf-a3b3-4f75-9f16-c29fd4a6dde1.txt b/output/text/5e7648bf-a3b3-4f75-9f16-c29fd4a6dde1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1dcda1542fb7d45b325fec4fa245d001b1bccbbe
--- /dev/null
+++ b/output/text/5e7648bf-a3b3-4f75-9f16-c29fd4a6dde1.txt
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+
+--- Page 1 ---
+Clinical Diagnosis & History:. Left renal mass. Specimens Submitted: 1: SP: Left kidney and adrenal glanc. 2: SP: Para-aortic lymph nodes DIAGNOSIS: 1)  KIDNEY AND ADRENAL GLAND, LEFT; EXCISION: - RENAL CELL CARCINOMA, CHROMOPHOBE CELL TYPE. - THE TUMOR'S GREATEST DIAMETER IS 5.2 CM. - THE TUMOR IS CONFINED WITHIN THE RENAL CAPSULE - NO INVASION OF THE RENAL VEIN IS IDENTIFIED. -ALL SURGICAL MARGINS ARE FREE OF TUMOR - THE NON-NEOPLASTIC KIDNEY SHOWS CHRONIC INTERSTITIAL NEPHRITIS.  - THE ADRENAL GLAND IS UNREMARKABLE. 2) LYMPH NODE, PARA-AORTIC; EXCISION: - ONE BENIGN LYMPH NODE (0/1). I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY ATIHAVE REVIEWED AND APPROVED THIS REPORT 1) The specimen is received fresh and is labeled left kidney and adrenal gland. It consists of a kidney, with perinephric fat, portion of ureter and hilar vessels. The adrenal gland is present. The overall dimensions of the specimen are18x 10 x 5.5cm. The kidney weighs 495 grams. The renal capsule strips easily. The kidney measures 15x 6x4.5cm. Within the upper pole of the kidney there is a yellow tan necrotic mass measuring 5.2 in greatest dimension. The tumor appears to be near the perirenal fat. The remainder of the renal parenchyma exhibits no lesion. The renal pelvis appears not to be involve by tumor.. The renal sinus appears not to be involve by tumor. The renal vein appears not to be involve by tumor. The perirenal fat is not involved. The adrenal gland measures 4.2 x 2.6 x 2.0cm and is unremarakable. Page 1 of2
+
+--- Page 2 ---
+The segment of ureter measures 8 cm in length and is unremarkable.. Representative sections are submitted. Summary of sections: T-tumor  TN-tumor and normal TC-tumor and capsule NK-normal kidney RP-renal pelvis UM-ureteral margin U-random ureter VM-vascular margin AG adrenal gland 2) The specimen is received in formalin, labeled "Para-aortic lymph nodes". It consists of a single piece of fatty tissue  measuring 3 x 1.5 x 0.5 cm. Entirely submitted for all of the possible lymph nodes. Summary of sections: U - undesignated Summary of Sections: Part 1:SP: Left kidney and adrenal glanc. Block Sect. Site PCs 1 AG 0 3 NK 0 1 RP 0 T 0 5 2 TC 0 3 TN 0 1 UM 0 1 VM 0 Part 2:SP: Para-aortic lymph nodes Block Sect. Site PCs 2 U 2 Page 2 of 2 END OF REPORT
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diff --git a/output/text/5e77b9f1-be47-4dba-b1a5-81ad8a75eafe.txt b/output/text/5e77b9f1-be47-4dba-b1a5-81ad8a75eafe.txt
new file mode 100644
index 0000000000000000000000000000000000000000..dbc1f9b11d637f06e19fc3a99339e331a75c00ee
--- /dev/null
+++ b/output/text/5e77b9f1-be47-4dba-b1a5-81ad8a75eafe.txt
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+
+--- Page 1 ---
+Page l of 3 UUID: 349F5609-E653-4CF0-B63C-AF01D68D40E7 Redacted ccD-6-3 8370/3 Site Adreu alGlandeortex General Pathologic Examination @ 74. AJ 4/z9/L3 Patient: Date of Report: This autopsy study was done for research purposes only and should therefore not be considered to be definitive or exhaustive. EXTERNAL EXAM: The body is that of a middle-aged, moderately obese Caucasian female, measuring 165 cm in length. The body is identified by ID bracelets about the left wrist and left ankle. Rigor mortis is not established and there is dependent lividity. The normocephalic head has been recently shaved or cut very close to the scalp. The external ears, nose, and mouth are unremarkable. The forward directed eyes show white sclera, blue irides, and the pupils are round, regular and equal. The chest is symmetrical and the breasts are normal without masses or skin lesions. The abdomen is obese and distended. There is a catheter protruding from a small incision in the right upper chest and beneath, subcutaneously, there is a palpable hard, disc-shaped device, about 2 cm in diameter, consistent in size and location with a medication port. There is a midline scar between the umbilicus and the symphysis pubis measuring 12 cm in length. The extremities are equally developed and the lower legs and feet are covered by gauze bandages (history of Herpes zoster skin lesions). There is edema of both feet. There is clear plastic tubing emanating from the urethra, connected to a plastic bag with approximately 50 ml of brownish-yellow fluid. The external genitalia are those of a normal female. The dorsum is unremarkable. INTERNAL EXAM: The body is opened with a thoracoabdominal incision to reveal all organs in their normal anatomic locations. A plastic and metal device consistent with a medication port is present subcutaneously over the upper part of the right chest, as described above on the external exam, measuring 2 cm in diameter. A plastic catheter is connected to the disc-shaped device. The pleural and abdominal cavities have the normal scanty amount of clear fluid. There are moderate adhesions between loops of small bowel and between the small bowel and ascending colon. Otherwise the pleural and peritoneal surfaces slide freely and are predominantly tan-pink and glistening.. Heart and Vessels: The heart weighs 320 grams. The heart slides freely within the pericardium and when incised there is a normal scanty amount of clear fluid present in the pericardial cavity. Limited dissection of the heart at autopsy reveals no evidence of infarctions. The left ventricular myocardium is 1.5 cm in maximal thickness. The thoracic and abdominal portions of the aorta have mild fatty streaking with no ulcerated plaques or calcifications. Lungs: The right and left lungs are normally Iobated and weigh 460 and 275 grams, respectively. The visceral pleura are pinkish-tan and moderately anthracotic. Hilar dissection reveals the bronchi and pulmonary arteries to be of normal configuration. No thrombi are identified. The cut surfaces of the left lung consist largely of crepitant, spongy, pink-tan parenchyma without masses, abscesses or consolidation except for focal dark red firm rubbery areas in the posterior lower lobe. The lower lobe, middle lobe and lower parts of the of the right lung are consolidated, firm to palpation and  dark red to black in color, with normal pinkish-tan crepitant parenchyma only in the upper part of the upper lobe. Esophagus: The esophagus is lined by Iongitudinally folded, gray-white mucosa without gross lesions. No masses or thickenings are identified. Stomach: The stomach contains approximately 50 cc of dark green liquid. The mucosa is soft, tan and has normal rugal folds without ulcers or masses. The gastric wall is of uniform consistency and thickness..
+
+--- Page 2 ---
+Page 2 of 3 Small Intestine: There are moderately frequent adhesions between loops of small bowel and between small bowel and ascending colon. The mucosa of the small intestine is tan with normal folds. The mesentery is normal, without masses or hemorrhage. Large Intestine: The ascending, transverse, descending and sigmoid colon as well as rectum are unremarkable except for the aforementioned adhesions with loops of small bowel. Pancreas: The pancreas is of normal size an'd shape, the cut surfaces showing normal tan-yellow, lobulated parenchyma. Liver: The normally Iobated liver weighs 2255 grams. There is an area of raised, knobby protrusions on the posterior and inferior surfaces of the right lobe, where the tissue has a yellowish tan color and is firm on palpation. Similar nodules of tissue protrude from other places on the capsule as well. Otherwise the capsule is smooth and red-brown. The cut surfaces reveal red-brown parenchyma of uniform consistency except for the presence of a large, multilobular, cauliflower-like, yellow-tan tumor, 12 x 10 x 6 cm, undemeath the region described as protruding from the inferior- posterior capsule. There are 3 or 4 similar nodules eIsewhere in the right lobe, having the same appearance but much smaller, 1-3 cm in diameter each.. Gallbladder: The gallbladder is present and contains a small amount of dark green bile without stones.. Kidneys: The left kidney weighs 120 grams. The perirenal retroperitoneal fat is hemorrhagic. The right kidney weighs 160 grams. Both have patent hilar vessels and the renal capsules peel from each with a little difficulty to reveal smooth red-brown cortical surfaces. Slices show well defined corticomedullary junctions, well-defined renal pyramids, patent calyceal system and pelves lined by finely folded, gray-white mucosa. Urinary Bladder: The bladder is small and contains no urine. The bladder wall is of uniform thickness and is spongy in. consistency. The mucosa is trabeculated and whitish-tan with frequent small petechial hemorrhages. Genital Tract: The vagina is unremarkable. The cervix, uterus, ovaries and fallopian tubes are absent. Thyroid Gland and Parathyroid Glands: The thyroid gland is symmetrical and red-tan in appearance. The cut surface shows homogeneous red-brown tissue. One parathyroid gland is identified. Adrenal Glands: In the regions where the right adrenal gland should be is a large, irregularly shaped mass, roughly ovoid, measuring 10 x 9.5 x 4 cm. Blunt dissection frees the abnormal mass relatively easily from all adjacent structures. Once dissected free, it weighs 22 grams. The cut surface shows two types of tissue, sharply demarcated roughly in the middle, with one type showing reddish-purplish-black soft spongy tissue while the other part shows yellow-tan, somewhat more firm tissue with a cauliflower-like appearance. The left adrenal gland is markedly swollen,. enlarged and has an abnormal bluish-purple-black appearance on cut section. Spleen: The spleen weighs 100 grams. The capsule is intact. The cut surfaces consist of soft, dark red-brown parenchyma with visible white pulp.. Lymph Nodes: The peribronchial lymph nodes are anthracotic. Elsewhere in the body, lymph nodes are of normal size and shape and are non-anthracotic. Skull and Brain -- see neuropath report Microscopic Examination: Paraffin-embedded H&E stained sections of organs and tissues show normal or unremarkable structure except for the following. There is adrenal cortical carcinoma involving the right adrenal gland with metastasis to the liver. There is acute bronchopneumonia involving the right lung with patchy infarct-like necrosis  and numerous coccoid bacteria. The lung away from the area of bronchopneumonia shows mild emphysematous change.
+
+--- Page 3 ---
+Page 3 of 3 small complex sclerosing Iesion (radial scar) with usual duct hyperplasia. There is minimal atherosclerosis in the thoracic and abdominal aorta. Final Body Diagnosis: 1.  Adrenal cortical carcinoma, right adrenal gland, with metastasis to liver 2. Hypertrophy, left adrenal gland 3. Acute bronchopneumonia with coccoid bacteria, right lung 4.  Mild emphysematous change with focal subpleural fibrosis, lung 5. Cardiomegaly 6. Mild atherosclerosis, aorta 7.  Benign breast tissue with small complex sclerosing lesion (radial scar) and usual duct hyperplasia 8. Perirenal hemorrhage, left kidney retroperitoneal fat 9. Adhesions, small and large bowel. 10. Status post hysterectomy with bilateral salpingo-oophorectomy 11. Status post subcutaneous Mediport placement, right upper chest Neuropathologist
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diff --git a/output/text/5e85407d-b98c-4e65-a897-090d233badb2.txt b/output/text/5e85407d-b98c-4e65-a897-090d233badb2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8036550c6cc9dfa02ec0ffac887ae99635e469cb
--- /dev/null
+++ b/output/text/5e85407d-b98c-4e65-a897-090d233badb2.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:385946B6-CD7F-45B5-BD72-AB6FDDCC9AB5 TCGA-YB-A89D-01A-PR Redacted Research Gross Description male with pancreatic mass Research Dx Pancreas, stomach, small intestine, pancreaticoduodenectomy: Adenocarcinoma. See case summary. CASE SUMMARY FOR CARCINOMA OF EXOCRINE PANCREAS: Specimen: Portions of pancreas, stomach, small intestine Procedure: Whipple resection Tumor site: Pancreas, with extension into ampulla and duodenal wall Tumor size: Approximately 3.2 x 2.5 x 2.0 cm Histologic type: Ductal adenocarcinoma Histologic grade: G2: Moderately differentiated Microscopic tumor extension: Tumor invades peripancreatic soft tissues Margins: Proximal magin (gastric or duodenal): Negative for carcinoma Distal margin (distal duodenal): Negative for carcinoma Uncinate process (retroperitoneal) margin (nonperitonealized surface of the uncinate process): Negative for carcinoma Bile duct margin: Negative for carcinoma Pancreatic resection margin: Negative for carcinoma Distance of invasive carcinoma from closest margin: 4 mm Specify margin: Uncinate Treatment effect: Not applicable Lymphovascular invasion: Indeterminate Perineural invasion: Present Pathologic staging (pTNM) Primary tumor (pT): pT3: Tumor extends beyond the pancreas but without involvement of the celiac axis or the superior mesenteric artery Regional lymph nodes (pN): pN1: Regional Iymph node metastases Number examined: 17 Number involved: 4 Distant metastasis (pM): pM: Not applicable AJCC Staging (7th edition): pT3 pN1 pM: Not applicable Research QC ICD o 3 Tumor: 70% tumor nuclei 850/3 5% necrosis 25% normal pancreas and stroma Sete Normal: 100% duct, stroma, adipose cps.1 ea tt Yancsons CQ5.7 Research Specimen QO 11/32J_3
+
+--- Page 2 ---
+Specimen Process Time Blood draw time: Plasma frozen time: Serum frozen time: Buffy coat frozen time: Tissue: Cold ischemia start time: Formalin fixation start time: Frozen start time: Total cold ischemia time Formalin fixation stop time: Total formalin fixation time: Specimen Weight Normal 1-181 mg Tumor 1-187 mg, 2-290 mg Specimen Size Plasma x 3 Serum x 2 Buffy coat x 1 Cryovials x 3 Normal x 1 Tumor x 2 Metastatic x 0 FFPE x 3 Normal x 1 Tumor x 2 Metastatic x 0 Study Patient Consent Yes k3 2
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diff --git a/output/text/5ea5d9a9-5266-4a70-a974-bf9f4751493b.txt b/output/text/5ea5d9a9-5266-4a70-a974-bf9f4751493b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..88d7c37efb1838005afd24cd72210567b073826d
--- /dev/null
+++ b/output/text/5ea5d9a9-5266-4a70-a974-bf9f4751493b.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis: Right hemicolectomy preparation with an ulcerated colon carcinoma characterized histologically as a poorly differentiated, partially mucinous adenocarcinoma of the colorectal type, located 0.5 cm aborally to Bauhin's valve and encircling the intestinal wall at a length of 5 cm. Invasive spreading of the tumor within all intestinal wall layers up to the bordering mesocolic fatty tissue and the level of the subserosa. Oral and aboral resection margins are tumor-free. Three of nineteen lymph nodes display metastasis of the colon carcinoma, not extending across the capsules. Stage of tumor is therefore: pT3, pN1 (3/19) L0 V0; G3 R0
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diff --git a/output/text/5eafa3fe-23ab-4268-b1af-697c0ab7af02.txt b/output/text/5eafa3fe-23ab-4268-b1af-697c0ab7af02.txt
new file mode 100644
index 0000000000000000000000000000000000000000..65f7f03e50db07ee178899cb0a692815c792bec9
--- /dev/null
+++ b/output/text/5eafa3fe-23ab-4268-b1af-697c0ab7af02.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+W UUID:00C6FB2B-A1C9-4310-B178-740313565A32 TCGA-GM-A3NW-01A-PR Redacted DIAGNOSIS (A) SENTINEL LYMPH NODE #1, BIOPSY: One lymph node, no tumor present (0/1) (B) SENTINEL LYMPH NODE #2, BIOPSY: One lymph node, no tumor present (0/1) (C) SENTINEL LYMPH NODE #3, BIOPSY: One lymph node, no tumor present (0/1) (D) LEFT BREAST, MASTECTOMY: INVASIVE LOBULAR CARCINOMA OF BREAST, MODIFIED BLACK'S NUCLEAR GRADE 1-2 (WELL TO MODERATELY DIFFERENTIATED), CLASSIC AND SOLID TYPES. INVASIVE CARCINOMA MEASURES 3.0 CM IN GREATEST DIMENSION. Lymphovascular invasion not identified. INVASIVE CARCINOMA LOCATED IN THE UPPER/INNER QUADRANT. Margins are widely free of tumor. Skin and nipple, no tumor present. (E) SENTINEL LYMPH NODE #4, BIOPSY: One lymph node, no tumor present (0/1) Entire report and diagnosis completed by COMMENT Immunohistochemical staining for cytokeratin is performed on sentinel lymph nodes #1, 2, 3, 4 is negative for metastatic carcinoma. 1cs-0-3 Iit: bust, nos eso.9. AN GROSS DESCRIPTION (A) SENTINEL LYMPH NODE #1, BLUE, IN VIVO - 72, EX VIVO 73 - A 1.6 x 0.8 x 0.8 cm lymph node. The lymph node is blue. Two touch preparations are made for intraoperative evaluation. The entire specimen is submitted in A.. *TP/DX: NO TUMOR PRESENT. (B) SENTINEL LYMPH NODE #2, (IN VIVO - 154, EX VIVO - 38) - A 0.8 x 0.8 x 0.6 cm lymph node. Two touch preparations are made for intraoperative evaluation and the entire specimen is submitted in B.. *TP/DX: NO TUMOR PRESENT. (C) SENTINEL LYMPH NODE #3, (IN VIVO - 461, EX VIVO - 635) - A 1.1 x 0.9 x 0.9 cm lymph node. Two touch preparations are made for intraoperative evaluation and the entire specimen is submitted in C.. *TP/DX: NO TUMOR PRESENT (D) LEFT BREAST, STITCH AT 12 O'CLOCK -- An oriented total mastectomy specimen (25.0 x 15.0 x 4.0 cm) with attached skin ellipse (19.0 x 5.0 cm) containing an inverted nipple and areola (2.0 cm diameter). The specimen is cut into 11 slices, numbered from medial to lateral. Located in the upper inner quadrant at 11o'clock is a 3.0 x 2.0 x 2.0 cm, poorly-circumscribed, multinodular,  heterogeneous, fleshy, brown, tan-white tumor mass, 1.0 cm from the superior superficial margin and approximately 1.0 cm from the deep margin. Adjacent breast tissue shows abundant firm white breast parenchyma in the lower outer quadrant. No other discrete lesions are identified. The skin and inverted nipple are grossly unremarkable.. INK CODE: Blue -- superior, orange -- inferior, black -- deep. SECTiON CODE: D1, D2, inverted nipple and areola; D3, superior superficial margin; D4, deep margin; D5-D11, tumor mass; D12, D13, representative lower inner quadrant; D14, D15, representative outer upper quadrant; D16, D17, representative lower outer quadrant. (E) SENTINEL LYMPH NODE #4, NOT BLUE, COUNT IN VIVO - 88, EX VIVO - 313 - Two fragments of red-tan adipose tissue (0.8 x 0.4 x 0.3, 1.0 x 1.0 x 0.4 cm). A single lymph node is identified (1.0 x 1.0 x 0.4 cm). The lymph node is trisected and reveals a slightly pink-tan cut surface. Two touch preparations are performed for immediate intraoperative evaluation. The entire Iymph node is submitted in E. *TP/DX: NO TUMOR PRESENT.
+
+--- Page 2 ---
+CLINICAL HISTORY Left breast cancer.. SNOMED CODES T-04050, T-C4710. M-85203 Released by: ---End Of RepORt---
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diff --git a/output/text/5eef86a8-57b5-42d4-8d82-5d8fa2c9f1a6.txt b/output/text/5eef86a8-57b5-42d4-8d82-5d8fa2c9f1a6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..728ee002ee397110be876d8232cb044ad62a7aad
--- /dev/null
+++ b/output/text/5eef86a8-57b5-42d4-8d82-5d8fa2c9f1a6.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID: 84C45214-ABFF-44F8-A315-04A8F646A57F Department of Pathology TCGA-P4-A5ED-01A-PR Redacted Tissue Source Site (TSS) #: Patient ID: Patholgy Accession No: Normal Sample ID: Pathology Report  DIAGNOSIS (A) LEFT KIDNEY: RENAL CELL CARCINOMA, PAPILLARY, TYPE 2, FUHRMAN'S NUCLEAR GRADE 3 (3.0 CM). (SEE COMMENT) TUMOR CONFINED TO THE KIDNEY. Ureteral and vascular margins free of tumor. COMMENT The tumor is a papillary renal cell carcinoma that exhibits extensive mucinous change appearing as basophilic intraluminal secretions on H & E. The Mayer's mucicarmine and Alcian blue stains are positive. The presence of an otherwise typical papillary renal cell carcinoma is an unusual finding. The tumor is negative for CD10. GROSS DESCRIPTION (A) LEFT KiDNEY - A left nephrectomy specimen, (12.0 x 5.7 x 5.0 cm), with associated perinephric fat and an attached ureter. The ureter is 7.0 cm in length with a diameter of 0.3 cm. The ureter and hilar vessels are grossly unremarkable.. In the superior pole of kidney, adjacent to the pelvis within the cortex is an ovoid circumscribed mass, 3.0 x 2.7 x 2.2 cm. The mass has a friable pale yellow to tan homogenous cut surface, and focally abuts the renal capsule. The mass does not infiltrate beyond the renal capsule into the perinephric adipose tissue and does not grossly invade the renal sinus. No hilar lymph  nodes are identified, and no tumor is identified within the renal vessels. The renal parenchyma away from the tumor is unremarkable, with firm red-brown cortex, distinct cortico-medullary.  junctions, and unremarkable uretero-pelvic mucosa. A portion of the tumor is submitted to the Tumor Bank and a portion is placed in glutaraldehyde for possible further electron microscopic studies. SECTiON CODE: A1, ureter and vascular margins; A2, normal kidney parenchyma from the inferior pole, including renal papillae, cortex, and pelvis; A3, tumor and renal capsule; A4, A5, tumor and renal pelvis interface; A6, A7, representative sections of tumor; A8, tumor and surrounding kidney; A9, tumor and adjacent pelvis. CLINICAL HISTORY Left renal mass. SNOMED CODES T-71000, M-Y7343 "Some tests reported here may have been developed and performance characteristics determined by. These tests have not been specifically cleared or approved by the U.S. Food and Drug Administration." -END OF REPORT- ILDo-3 8Q40/3 Site: DKidney NsS b 12|3y1>
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diff --git a/output/text/5ef89c46-d120-4013-978a-443d9839be89.txt b/output/text/5ef89c46-d120-4013-978a-443d9839be89.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7eed44fadb2b58f1858e97f86505284b6ed01287
--- /dev/null
+++ b/output/text/5ef89c46-d120-4013-978a-443d9839be89.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Ics-0-3 Csrtinons,unfi1trating ouct, Nos 85oof3 1/211 Procedure Date. Procedure Physician. Attending Physician/Copies To: UUID:E66D3DF8-1605-4EFD-AAFA-74F82366FD16 TCGA-BH-A1ET-01A-PR Redacted PATIeNT HISTORy: * DATE of LMP: * DATE OF LAST DELIVERY: * PRE-OP DIAGNOSIS: CANCER LEFT BREASTS POST-OP DIAGNOSIS: SAME OPERATIVE PROCEDURE: LEFT SEGMENTAL MAST, LEFT AXILLARY DISS CLINICAL HISTORY: MATERIAL SUEMITTED: A)(LEFT BREAST BIOPSY/MASS/SEGMENTAL MASTECTOMY, PROCUREMENT BY SURGICAL PROCEDURE B) LEFT AXILLARY LYMPH NODE(S), PROCUREMENT BY SURGICAL PROCEDURE ADDENDA: Addendum MACROSCOPIC"DrsCRIDTION: BloCk "A2" for ER/PR and HER-2/neu FINAL DIAGNOSIS: ER/PR RESULTS IMMUNOPEROXIDASE IDENTIFICATION OF ESTROGEN AND PROCESTERONE RECEPTORS IS CARRIED OUT ON SLIDE "A2". DISTINCT INTRANUCLEAR STAINING IS IDENTIFIED FOR ESTROGEN RECEPTOR (95t) AND PROGESTERONE RECEPTOR (SOt). THEREFORE, BOTH ARE INTRRPRETED AS POSITIVE.S HER-2/NBU RESULTS AS PER THE REQUEST OF DR. BAFFONI, c-erbB2 (HER-2/NEU) IMUNOSTAINING IS CARRIED OUT ON PREVIOUS MAGEE r BLOCK "A2" (BREAST CANCER) USING A 1:3OO DILUTION Or DAKO'S POLYCLCNAL ANTIBODY A485 (DIRECTED AGAINST THE INTRACELLULAR DOMAIN OF C-erbB2) WITHOUT ANTIGEN RETRIEVAL. NO DISTINCT COMPLETE MEMSRANE STAININC IS IDENTIPIED. THERSFORE, C-erbB2 (HXR-2/NEU) IS INTERPRETED AS NEGATIVE (SCORE O). FINAL DIAGNOSIS: FINAL DIAGNOSIS: A) LEFT SREAST, SEQMENTAL MASTECTOMY: INFILTRATING MODERATELY DIFFERENTIATED DUCT CARCINOMA NITH FOCAL LORINAR FEATURES. 2.O CM. (AS MEASURED ON GLASS SLIDE),.. .POOR ARCHITECTURAL GRADE,. INTERMEDIATED NUCLEAR GRADE (NOTTINGHAN SCORE-6, TUBULES-3, MITOTIC RATE-1, NUCLEAR PLEOMORPHISM-2) (SEE NOTE) (CROSS REFER A - FIBROCYSTIC CHANGES WITH ATYPICAL DUCTAL EPITHELIAL HYPERPLASIA PAPILLOMATOSIS WITH ASSOCIATED MICROCALCIFICATIONSS - MARGINS OF RESECTION ARE FREE OF TUMORS B) LEFT AXILLARY CONTENTS:  ONE OF NINETEEN (L/19) LYNPH NODES POSITIVE FOR METASTATIC CARCINOMA
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diff --git a/output/text/5f2d0825-4d1f-4121-89ef-9824ec577dd2.txt b/output/text/5f2d0825-4d1f-4121-89ef-9824ec577dd2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..cd4dab6b0fffbb61b80d0fe88b209175dfa82ec1
--- /dev/null
+++ b/output/text/5f2d0825-4d1f-4121-89ef-9824ec577dd2.txt
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+
+--- Page 1 ---
+FINAL DIAGNOSIS: Part 1: _Breast, right, Segmental mastectomy at 10 O'clOck -- A. InVaSIVE DUcTAL CARcinomA, NO SPeCIaL TYPE, WITH ABUnDanT CALCIFIcATIONS. B. NOTTinghAm GrADe 2 (tubuLe fOrmAtiOn: 2, nUclEAR PLeOmOrphiSm: 2, mITOtIc ActivIty: 2; Total Score = 6/9). c.  THE INVASIVE TUMOR MEASURES 1.8 CM IN LARGEST DIMENSION. D. DUctal CArcinoma In Situ, nuclear gRaDe 2, Cribriform type wIth CaLCifiCatIOnS. E. tHE DUCtAl CARCiNOmA IN SItU CONStiTuteS 5% Of ThE tOtAl TUmOR VOLUME AND iS PRESENT ADmIxed wIth The InVaSiVe COmponent. F. LYMPHOVASCULAR SPACE iNVASION IS NOTED. G.  RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA. H. iNVASIVE CARCINOMA IS 0.1 CM FROM THE NEAREST (ANTERIOR) MARGiN AND iS 0.2 CM FROM THE POSTERIOR MARGIN (PLEASE SEE PART #2 FOR NEW ANTERIOR MARGIN). THE NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES AND COLUMNAR CELL CHANGES. J. PREVIOUS BIOPSY SITE CHANGES. K. THe InVASIVe TUmOR CELLS ARE POSITiVE fOR eSTROgeN RECEpTORS (H SCORE OF 200), PROGESTERONE RECEPTOR (H SCORE OF 290) AND NEGATiVE FOR HER-2 AS PER PREVIOUS PatholOgy rEpOrt part 2: breast, right, new anterior margin, re-excision --. BENIGN BREAST TISSUE. part 3: Lymph nOdes, Right AxiLLA, SEntinel #1, excisiOn - METASTATIC CARCINOMA INVOLViNG ONE OF TWO LYMPH NODES (1/2). A. B. THE METASTATIC FOCUS MEASURES 0.1 CM IN LARGEST DIMENSION. C. NO eXTRACApSULAR eXTeNsiON IS IDenTifieD. 1c b-0-3 PART 4: LYMPH NODES, RIGHT AXILLA, SENTINEL #2, EXCISION -- TyRee ! ymph nOdeS, nEgaTiVe FOr metastATic tumOr inR! Srh;brast N0s C5U.9 3/isfu h CASE SYNOPSIS: SYNOPTIC - PRIMARY iNVASIVE CARCINOMA OF BREAST LATERALITY: Right PROCEDURE: Segmenta! LOCATION: Upper outer quadrant SiZE OF TUmOR:  Maximum dimension invasive component: 1.8 cm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: No TUMOR TYPE (invasive component): Ductal adenocarcinoma, NOS NOTTINGHAM SCORE: Nuclear grade: 2 Tubute formation: 2 Total Nottingham score: 6 Nottingham grade (1, 2, 3): 2 ANGIOLYMPHATIC INVASION: Yes DERMAL LYMPHATIC INVASION: Not applicable CALCIFICATION: Yes, malignant zones Tumor type, in situ: Cribriform SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: UUID:C9AD69E8-506A-4442-B1C2-C8F09B519CB23 No TCGA-BH-A0HO-01A-PR Redacted SURG MARGINS INVOLVED By in SITU COMPONENT: No LYMPH NODES POSITIVE: 1 LYMPH NODES EXAMINED: 5 METHOD(S) OF LYmPH nODE EXAMINATION: H/E stain, Keratin stain SENTINEL NODE METASTASIS: Yes SIZE OF NODAL METASTASES: Diameter of largest lymph node metastasis: 1 mm LYMPH NODE METASTASIS(-ES) WITH EXTRACAPSULAR EXTENSION: No NON-NEOPLASTIC BREAST TISSUE: FCD T STAGE, PATHOLOGIC: pT1c N Stage, pathologic: pNX M STAGE, PATHOLOGIC: pMX ESTROGEN RECEPTORS:  positive PROGESTERONE RECEPTORS: positive HER2/NEU: 313/1 zero or 1+ Comment: The tumor N stage is at least pN1mi. If a sentinel node is positive, then a final "N. stage" can be assigned only after complete lymph node dissection.
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diff --git a/output/text/5f3c8fd1-3a3a-4c06-b3c2-0ee0f1aa9df9.txt b/output/text/5f3c8fd1-3a3a-4c06-b3c2-0ee0f1aa9df9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e8efbf92211507e5a116b4c2c409d9eee6e7352e
--- /dev/null
+++ b/output/text/5f3c8fd1-3a3a-4c06-b3c2-0ee0f1aa9df9.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis: This is a poorly differentiated adenocarcinoma of the colon (descending/sigmoid colon) of histopathological differentiation grade G3, with ulceration of the inner surface of the tumor, peritumorous, chronic recurrent concomitant inflammation, focal mucus formation, tumor infiltration in the parietal layers of the colon as fas as the subserous fatty connective tissue, with twelve local lymph node metastases (12/18), with carcinomatous lymphangitis and carcinosis of the blood vessels. In addition the overview slices from the resection margins show these to be tumor-free, and the sigmoid colon shows diverticulosis. According to the sections available, the tumor spread of the colon carcinoma corresponds to a tumor stage of pT3, pN2, MX, L1, V1.
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diff --git a/output/text/5f40c5c0-c7c4-4887-8f99-7b4d576e4deb.txt b/output/text/5f40c5c0-c7c4-4887-8f99-7b4d576e4deb.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f0f4aa9cb5772711a110f404f35e1f44a79e9631
--- /dev/null
+++ b/output/text/5f40c5c0-c7c4-4887-8f99-7b4d576e4deb.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Path (First Tumor) Tumor Site: Ascending Colon Date of Cancer Sample Procurement: Histology: Adenocarcinoma Description of other histology: Grade: Moderately Differentiated  Yes Mucinous: C No r Yes r Unknown (Focal)  Yes Signet Ring Feature:  No C. Yes  Unknown (Focal) Histologic Heterogeneity: 6 No ( Yes C Unknown Host Response: None Crohn's like reaction  None r. Yes C Unknown Plasma cell rich stroma C No C: Yes C Unknown  Expansile Growth Pattern: ~ Expansile 6 Invasive  Unknown and Invasive Inflammatory Bowel Disease 6 No ( Yes C Unknown Angiolymphatic Invasion: C No 6 Yes C Unknown Mutator Phenotype: 6 No C Yes  Unknown Number of Slides 1 C Yes Garland Necrosis present: C No  Yes C Unknown (Focal) TIL Cells/ HPF 1 Pathologist Comment: 1cb-0-3 Qdenecircnoma, mucnou, Nos 848of3 Sit: ascndig coln C18.7 UUID:189E9C45-C8A3-4CFA-AB47-965056517D4D Redacted hr 5/3/1 TCGA-DM-A285-01A-PR
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diff --git a/output/text/5f48465f-5ab3-4b0d-bf2f-b917c6567d13.txt b/output/text/5f48465f-5ab3-4b0d-bf2f-b917c6567d13.txt
new file mode 100644
index 0000000000000000000000000000000000000000..59ca97bed21ae1e4f1d8dae2390b0aee4dce5c96
--- /dev/null
+++ b/output/text/5f48465f-5ab3-4b0d-bf2f-b917c6567d13.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:436F3280-98C7-4FA9-BD6F-1B02CAF1D262 TCGA-PL-A8LZ-01A-PR Redacted 10-0.3 lreenonus, tryltiativey oleetNigS J850/3 Age: l0uaFNoS Sex: Female C so9 Tissue Source Site (TSS): S 8/4/i4 Date of Tumour Procurement:. 1. GROsS ASSESSMENT: Cut section showed a chalky white tumour. 4x3x2cm, 2.MICROSCOPIC ASSESSMENT Microscopic description: Section shows an invasive tumour growing in solid nests and tubular patterns. It is composed of cells having moderately pleomorphic hyperchromatic nuclei and amphophilic cytoplasm. The stroma is desmoplastic containing thin-walled vascular channels, tumour cells and lymphocytes. Focal areas of necrosis noted, 3. Tumour Type: Malignant 4. Tumour Site: Left Breast 5.Distance of invasive carcinoma to closest margin: 5mm .Which margin? Deep resection
+
+--- Page 2 ---
+TSS Unique patient ID: 6.HISTOLOGICAL DIAGNOSIS: Invasive ductal carcinoma, NOS 7. COMMENTS: nil Dr Reporting Pathologist Name Signature Date
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diff --git a/output/text/5f4d10dc-7734-438f-b294-82026497dd11.txt b/output/text/5f4d10dc-7734-438f-b294-82026497dd11.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e0f85e4e5a9216e9772a91a9072d13711ae85f38
--- /dev/null
+++ b/output/text/5f4d10dc-7734-438f-b294-82026497dd11.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis: In I) II) a moderately differentiated invasive carcinoma of the colorectal type with penetration of. all parietal layers and with vascular infiltration (G2, pT3, L1, V1), as well as free lymph nodes (0 of 13). Tumor classification: ICDO-DA M8140/3 G2, pT3, L1, V1, pN0 (0 of 13), locally R0 M classification in the context of the oncology conference
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diff --git a/output/text/5f9dca84-2c75-4de5-997f-17356f8dca28.txt b/output/text/5f9dca84-2c75-4de5-997f-17356f8dca28.txt
new file mode 100644
index 0000000000000000000000000000000000000000..89e1604d3c298bda8dada664792bbbf67445ee0f
--- /dev/null
+++ b/output/text/5f9dca84-2c75-4de5-997f-17356f8dca28.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+UUID: 25613DC3-ED19-47CD-AD6C-C900403D2E37 Redacted Age: Print Date/Time: arcinsme Surgical Pathology C eQ0 8268/3 Histopathological Examination. xJ s/ioH3 Collected: Received: Complete: Pre-Op Diagnosis  Left Renal Cancer, Enlargement. Of Lymph Nodes Order Physician Specimens Kidney. left for Omental Biopsy Lymph Node, Left Pelvic Frozen Diagnosis : Report : GROSS EXAMINATION: A. The specimen is received fresh in a container labeled with the name of the patient and as kidney, left.. Size: 14.5 x 8 x 7 cm Weight: 386 g Perinephric fat: Moderate amount attached. Ureter dimensions: 3.5 x 0.7 cm Tumor: Size: 5.5 x 5 x 4.3 cm Description: Friable, tan-pink, and hemorrhagic. Location: Mainly in the mid pole with no involvement of. extreme upper or lower poles. Extent: Capsule/perinephric fat: Uninvolved. Renal sinus: Possibly involved. Pelvis/calyces: Uninvolved/calyces involved Renal vein: Uninvolved Adrenal: Absent Distance to margins: Gerota's fascia: 0.3 cm Ureteral: 7 cm Hilar: 2 cm Renal vein: 1.6 cm Adrenal: Absent Lymph nodes: No Ink code: Gerota's fascia-black, hilar soft tissue. margin-green Representative sections are submitted:. Al. Ureteral and vascular margins, en face. A2. Hilar soft tissue margin, en face
+
+--- Page 2 ---
+THIS CONFIDENTIAL AND PRIVILEGED DOCUMENT/INFORMA ION IS PROTECTED BY FEDERAL AND STATE LAW. UNAUTHORIZED DISCLOSURE, DISSEMINATION OR DUPLICATION IS PROHIBITED Page 1 of 4 Visit #: A3. Tumor and renal sinus A4-A5. Tumor and calyces A6. Tumor and Gerota's fascia A7. Tumor with adjacent parenchyma. A8. Remaining parenchyma B. The specimen is received labeled with the name of the. patient and as omental mass. It consists of an irregular portion of soft tan-brown tissue and attached fat measuring 2.5 x 1.5 x 1.1 cm. The specimen is inked blue. Cut sections reveal a red-brown cut surface. The specimen is entirely submitted in Bl-B3.. C. The specimen is received labeled with the name of the patient and as lymph node, left pelvic. It consists of two irregular pieces of soft tan-brown tissue measuring 3 x 1.6 x 1.3 cm. The specimen i.  serially sectioned and entirely. submitted in Cl-c5. MICROSCOPIC EXAMINATION: Sections of the grossly identified renal tumor show carcinoma with papillary morphology. The tumor is characterized by multinodular growth and tumor cells with moderately pleomorphic medium to large oval nuclei with occasional nuclear grooves and ample eosinophilic to vacuolated cytoplasm. In areas the papillary formations are densely packed and essentially solid. There is multifocal intratumoral hemosiderin and formation of cystic nodules filled with papillary tumor and blood. Tumor abuts the fibrous renal capsule, but does not clearly invade perirenal fat on multiple levels examined. There is invasion of small non-muscularized veins in the renal sinus but no definitive invasion of the renal sinus fat or large branches of the renal vein. The tumor is associated with a significant and extensive diffuse and nodular lymphocytic infiltrate at the periphery of the lesion that also extensively involve perinephric and renal sinus fat, and show sheets and nodules of cells extensively involve the remaining non-carcinomatous renal cortex. These are monomorphic-appearing small lymphocytes, and by immunohistochemistry are diffusely positive for cD20 and BcL-2. The same B cells are negative for cD5 and cD23, which highlights residual germinal center dendritic cells. CD3 and cD5 show staining in a smaller population of T lymphocytes. BcL-6 and cyclin Dl are negative. Sections of the omental nodule show a spherical accessory spleen with relatively normal splenic architecture and small periarterial lymphoid nodules. The adipose tissue. surrounding the splenule is involved by dense sheets and nodules of the same lymphoid infiltrate with identical
+
+--- Page 3 ---
+immunophenotype to the kidney. The* Yeft pelvic lymph node shows involvement by both metastatic papillary carcinoma and. the same abnormal lymphoid population, with near complete effacement of residual normal nodal architecture in the. THIS CONFIDENTIAL AND PRIVILEGED DOCUMENT/INFORMATION IS PROTECTED BY FEDERAL AND STATE LAW.  UNAUTHORIZED DISCLOSURE, DISSEMINATION OR DUPLICATION IS PROHIBITED Page 2 of 4 Visit #: non-carcinomatous areas. Positive and negative control slides are appropriate.. DIAGNOSIS BASED ON GROSS AND MICROSCOPIC EXAMINATION: A. Kidney, left, radical nephrectomy:. - Papillary renal cell carcinoma (histologic type 2), 5.5 cm. in greatest dimension. - Carcinoma is confined to the kidney, without invasion of renal sinus fat, muscularized branches of the renal vein, or perinephric fat. - Carcinoma shows invasion of small non-muscularized vessels. in renal sinus. - Small B-cell lymphoma most consistent with extranodal. marginal zone lymphoma, with diffuse involvement of kidney, perinephric fat, and renal sinus..  Ureter, vascular, and soft tissue resection margins are negative for carcinoma. - See B. Omentum, excisional biopsy of mass:. -- Accessory spleen, with surrounding adipose tissue involved. by small B-cell lymphoma. C. Lymph node, left pelvic, excision: - One lymph node, involved by both metastatic papillary renal cell carcinoma and small B-cell lymphoma. CANCER CASE SUMMARY KIDnEy: Resection (Version 3.0.0.0.) SPECIMEN PROCEDURE: Left radical nephrectomy TUMOR SITE: Middle TUMOR SIZE: 5.5 x 5 x 4.2 cm TUMOR FOCALITY: UnifoCal MACROSCOPIC EXTENT OF TUMOR: Limited to kidney HIsToLogIc TypE: Papillary renal cell carcinoma SARCOMATOID FEATURES: Not identified. TUMOR NECROSIS: Not identified. HISTOLOGIC GRADE: Not applicable
+
+--- Page 4 ---
+THIS CONFIDENTIAL AND PRIVILEGED DOCUMENT/INFORMATION IS PROTECTED BY FEDERAL AND STATE LAW. UNAUTHORIZED DISCLOSURE, DISSEMINATION OR DUPLICATION IS PROHIBITED Page 4 of 4 Visit #: r Site Discrepancy +/13
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diff --git a/output/text/5fa5aae5-e056-4b73-af9d-ef6b69de63df.txt b/output/text/5fa5aae5-e056-4b73-af9d-ef6b69de63df.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ea7dd97d49fa0438d3bd8ddcdf8bc4c5a83d5d31
--- /dev/null
+++ b/output/text/5fa5aae5-e056-4b73-af9d-ef6b69de63df.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID: F501AF08-A89D-4B4B-9A18-07DC938D8233 TCGA-VD-AA8M-01A-PR Redacted Department of Pathology. HISTOPATHOLOGY Surname Lab No Clintcal Consultant & Location DOB/Age Sex Forename(s) Unit No Request Date This Copy For: Icd63 SPECIMEN Mlgnsna,eysithalioiel 9 R RIGHT GLOBE ENUCLEATION aeQl mi jel 877cJ3 CLINICAL DETAILS Sit CowoL069.3 ?Choroidal melanoma No previous treatment. YJ s/B0/i4 MACROSCOPIC DESCRIPTION A fresh intact right globe. Dimensions: Axial 26.5mm Horizontal 25.5mm Vertical 26mm Cornea: Horizontal 12mm Vertical 12mm. Optic Nerve: Length 35mm Diameter 4mm.. On trans-illumination, a shadow is seen approximately 14mm. posteromedially. Plane of Section: Horizontal. Intraocular description:. On opening, a solitary domed shaped piebald choroidal mass is seen approximately 3mm away from optic disc. Tumoux Size: 12mm Height 7mm MICROSCOPY Histologically, the enucleated eye demonstrates a normal. anterior segment with an unremarkable cornea, a deep anterior chamber and open angles. The iris leaves are unremarkable. The lens shows advanced cataractous changes. In the posterior segment, close to the optic nerve head, a. choroidal melanoma can be seen. This is dome-shaped with a large accompanying exudative retinal detachment with haemorrhage. The retina overlying the tumour is atrophic with degenerative changes.. Reported: Pathologist: Electronically Verified:
+
+--- Page 2 ---
+printed: Department of Pathology Page 2 of 3 , HISTOPATHOLOGY REPORT Tel: Surname  Lab No Clinical Consultant & Location Forename(s)  DOB/Age Sex Unit No Request Date This Copy For: The tumour is pigmented and consists of a mixture of cells, both epithelioid and spindle cells, with a dominance of the latter cell type.  The melanoma celis are immunoreactive  for MelanA, CDi17 and Hsp-27 (score 2). The number of mitoses is approx. 7/40 high power fields. The microvasculature of the melanoma is prominent, and closed loops are present in the tissue planes evaluated. The lymphocytic infiltrate within tumour is minimal. Macrophages are scattered throughout the tumour in a moderate density.There is no evidence of scleral invasion or of extraocular growth. The optic nerve is tumour free, and demonstrates mild atrophic changes.  The examined vortex veins are free of tumour. FINAL DIAGNOSIS Choroidal melanoma of mixed cell type. COMMENT Molecular genetic examination of DNA extracted from the. tumour celis will be performed using multiplex-ligation dependent probe amplification (MLpA). looking at chromosomes 1 3, 6 and 8. A supplementary report will follow as soon as these investigations are complete. SUPPLEMENTARY REPORT In the meantime MLpA was performed on the DNA extracted from. the tumour material. The MLpA results demonstrate: Borderline gains of chromosome 1p 2 borderline losses and 4 borderline gains in chromosome 3 2 borderline gains in chromosome 6p Normal chromosome 8q. The molecular genetic results are unclear and so MsA will. be performed to clarify the status of chromosome 3. A final report will follow. Reported: Pathologist: Electronically Verifled: 
+
+--- Page 3 ---
+printed: Department of Pathology. Page 3 of 3 HISTOPATHOLOGY REPORT Tel:  Surname Lab No Clinica) Consultant & Location Forename(s)  DOB/Age Sex Unit No Request Date This Copy For:. SUPPLEMENTARY REPORT In the meantime, MsA was performed on the DNA extracted from. the tumour sample and compared with that extracted from the patient blood. The MsA results suggest that there is no loss of. heterozygosity (NLoh) for 2 of the three 3 loci examined on. chromosome 3p, and NLoh for 3 of four loci on chromosome 3q. These results are consistent with disomy 3. COMMENT Taking the mLpA and msA results together, they would suggest that the status of chromosome 3 in the tumour cells is. normal (i.e. disomy 3).. Reported: Pathologist: Electronically Verified: dw 12/9/13] nous Prin
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diff --git a/output/text/5fc202c2-c834-4bbc-810f-dc885b1179cf.txt b/output/text/5fc202c2-c834-4bbc-810f-dc885b1179cf.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b8c215f888e47d5e44eb81cfad6655b8aa6c3bda
--- /dev/null
+++ b/output/text/5fc202c2-c834-4bbc-810f-dc885b1179cf.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+CGA-B8-A8YJ-01A-PR Redacted SURGICAL PATHOLOGY Case Number : Diagnosis: A: Kidney, right, robotic partial nephrectomy IDO 3 Coureentm, c&ar cekk 8ai/3 Procedure: partial nephrectomy Sste. RBidnylVoc Cic4.9 Laterality: right IO 4|3J14y Histologic tumor type/subtype: renal cell carcinoma, clear cell type Sarcomatoid features: not identified Histologic grade (if applicable): Fuhrman nuclear grade 2 Tumor size (greatest dimension): 4.4 cm (gross measurement) Tumor focality: unifocal Extent of tumor invasion (if present specify if macroscopic or microscopic): Capsular invasion/perirenal adipose tissue: not identified Gerota's fascia: not present in specimen Renal sinus: not present in specimen. Major veins (renal vein or segmental branches, Ivc): not present in specimen Ureter: not present in specimen. Venous (large vessel): not present in specimen Lymphatic (small vessel): not identified. Histologic assessment of surgical margins: Renal parenchymal margin (partial nephrectomy only): free of tumor Renal capsular margin (partial nephrectomy only): free of tumor Paranephric adipose tissue margin (partial nephrectomy only): free of tumor Adrenal gland: not present in specimen Lymph nodes: none submitted Pathologic findings in non-neoplastic kidney: none
+
+--- Page 2 ---
+AJCc Staging: pT1b pNx This staging information is based on information available at the time of this report, and is subject to change pending clinical review and additional information.. Clinical History: -year-old female with a right renal mass.. Gross Description: Received is one appropriately labeled container, additionally. labeled "right renal mass." It holds a 47.8 gram aggregate in total, 25 gram, 4.8 x 4.5 x 2.5 cm resection of kidney and separate lobulated, focally cauterized fat. The identified renal capsule is inked black, and the exposed parenchymal margin is. inked blue. Sectioning demonstrates a 4.4 x 3.2 x 2.5 cm well circumscribed hemorrhagic cortical nodule with bright orange borders. This nodule comes within 0.1 cm of multiple blue inked parenchymal margins, expands the capsule, and comes within less than 0.1 cm of multiple black inked capsular margins. There is a compressed rim of gray/tan kidney tissue present. Tumor and. normal is given to tissue procurement. Representative sections are submitted in blocks Al-A7 and representative sections from the aggregate of fat are submitted in block A8. Tissue remains in formalin.. .
\ No newline at end of file
diff --git a/output/text/5fc45b53-4f22-4c28-9b83-dcae25c6faf8.txt b/output/text/5fc45b53-4f22-4c28-9b83-dcae25c6faf8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c401e767425efb4bfca478e9c396d298c256dc10
--- /dev/null
+++ b/output/text/5fc45b53-4f22-4c28-9b83-dcae25c6faf8.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+7-05AC-498F-A09B-37833A70031B TCGA-IZ-A6M8-01A-PR Redacted Page I of 4 MRN Gender M Name Date Of Birth Encounter Number COPY ONLY DO NOt FILE SURGICAL PATHOLOGY Time Collected Time Received Time Reported Order Number Ordering Provider Status Final Results Final Source df specimen RIGHT KIDNEY PROXIMAL URETER- 1gD-0 -3  FINAL DIAGNOSIS: srerurna RIGHT KIDNEY PROXIMAL URETER- Nenol  ceQl 60t RENAL CELL CARCINOMA, LIMITED TO KIDNEY. SEE SYNOPTIC REPOR Sute yinyoS SIMPLE CORTICAL CYSTS. C64.9 SYNOPTIC REPORT: AJ 7/24/3  RENAL CELL CARCINOMA. PROPORTION OF SARCOMATOID COMPONENT: O % SPECIMEN LATERALITY: RIGHT. TUMOR FOCALITY: FOCAL. TUMOR SIZE (LARGEST TUMOR, IF MULTIPLE) : 2.5 CM.) HISTOLOGIC TYPE: PAPILLARY TYPE. HISTOLOGIC GRADE (FUHRMAN NUCLEAR GRADE) : 2/4.) TNM STAGE: pTla, pNx, pMx. (Tla: not> 4 cm; T1b: not > 7 cm; T2a: not > 10 cm; T2b: > 10 cm) (NO: negative node;  N1: regional nodes) Prepared for "
+
+--- Page 2 ---
+Page 2 of 4 LYMPH NODE(S) INCLUDED IN ALL PARTS: NONE SUBMITTED. LYMPHATIC (SMALL VESSEL) INVASION: IS NOT SEEN. SPECIMEN TYPE: RIGHT RADICAL NEPHRECTOMY. SPECIMEN SIZE: 18.0 x 10.0 x 7.0 CM (OVERALL) AND KIDNEY PROPER 9.0 x 5|0 x 4.0 CM. ADRENAL |GLAND: N/A. NO TUMOR SEEN AT RESECTION MARGINS. Comment EVALUATION OF NON-NEOPLASTIC RENAL PARENCHYMA: DIFFUSE  AND EARLY NODULAR MESANGIAL SCLEROSIS, MOST LIKELY AN EXPRESSION OF EARLY DIABETIC GLOMERULOSCLEROSIS ADVANCED| CHRONIC CHANGES OF THE KIDNEY PARENCHYMA, INCLUDING: - FOCAL GLOBAL GLOMERULOSCLEROSIS ( 80% OF GLOMERULI)  TUBULAR ATROPHY AND INTERSTITIAL FIBROSIS (>6O%OF THE PARENCHYMA) - ARTERIAL AND ARTERICLAR SCLEROSIS, MODERATE, WITH SUBCAPSULAR VASCULAR SCARS JONES, PAS AND TRICHROME EXAMINED. Signature (Case signed Case clinical Information BILATERAL RENAL CELL CARCINOMA Gross Description Received in formalin labeled with the patient's name and "right kidney and proximal ureter" is a previously inked and bivalved 400 gram Total nephrectomy specimen with attached perinephric fat. Ovetall dimensions of the specimen are 18 x 10 x 7 cm. The kidney proper measures 9 x 4 x 5 cm. The vessels at the hilum are identified. The ureter is identified and measures 2. cm in length. Grossly, no lymph nodes are identified at the hilum. On the bivalved kidney, the cut surface is remarkable for an engapsulated, circumscribed, tan/yellow mass measuring Prepared for
+
+--- Page 3 ---
+Page 3 of 4 2.5 x 2 x 2 cm. The mass grossly appears to be pushing the capsule  Adjacent to the mass is a 2.5 cm cystic structure that is lined with a tan, glistening and grossly unremarkable tissue with no excrescences. The mass measures to the Up junction of the specimen 3.8 cm. The remainder of the cut surface reveals several|additional cortical cystic structures ranging in size from 0.$ cm down to 0.2 cm. Further sectioning the kidney, on the opposite pole of the mass the cut surface reveals a smooth 0.5 cm nodule measuring to the capsule and fatty tissue 0.8 cm. The remainder of the cut surface is grossly unremarkable. No adrenal |gland was identified in the specimen. Representative sections  are submitted as follows: Al=right ureter resection margin; A2=remainder of vessels at hilum; A3-A7-entire mass demonstrating mass to capsule and fat; A8, A9=representative sections of cystic structure adjacent to mass previously described; Al0=representative section of additional smaller nodule;  All=representative section of additional smaller. cortical cyst; A12-representative section of up junction tissue, A13= ureter. Physicians Procedure A. AA ROUTINE H&E X1 BLOCK.1 H&E X1 A|RECUTS A. AA ROUTINE H&E X1 BLOCK.2 H&E X1 A. AA ROUTINE H&E X1 BLOCK.3 H&E X1 A. AA ROUTINE H&E X1 BLOCK.4 H&E X1 A. AA ROUTINE H&E X1 BLOCK.5 H&E X1 A. AA ROUTINE H&E XI BLOCK.6 H&E X1 A. AA ROUTINE H&E X1 BLOCK.7 H&E X1 A. AA ROUTINE H&E X1 BLOCK.8 H&E X1 A. AA ROUTINE H&E X1 BLOCK.9 H&E X1 A. AA ROUTINE H&E X1 BLOCK.10 H&E X1 JONES PAS TRICHROME A. AA ROUTINE H&E X1 BLOCK.11 H&E X1 A. AA ROUINE H&E X1 BLOCK.12  Prepared for
+
+--- Page 4 ---
+Page 4 of 4 H&E X1 A. AA ROUTINE H&E X1 BLOCK.13 H&E X1 Prepared for .e Pur Tss,Patnt ncewwl mo chumo c malgnonin BC w 7/3|13 is (circle
\ No newline at end of file
diff --git a/output/text/5fd0a615-c736-417a-b75a-26243a81c77b.txt b/output/text/5fd0a615-c736-417a-b75a-26243a81c77b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6edac9fbe9053ea8902c35eeef9d368115762b36
--- /dev/null
+++ b/output/text/5fd0a615-c736-417a-b75a-26243a81c77b.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:03056B3E-B81F-44C0-B21E-6C850D67DB430 TCGA-DD-AAD3-01A-PR Redacted CLINICAL DIAGNOSIS: HCC Specimen : Liver. Gross Photo :. GROSS: Specimen status: Fresh Operation: Right posterior sectionectomy Organ: Liver (13.2 x 9.1 x 5.1 cm, 148.0 gm) Lesion: Hepatic mass Size: 5.0 x 4.2 x 3.9 cm Cut surface: Encapsulated, pale tan, solid and lobulated mass No necrosis and hemorrhage Gross type: Multinodular confluent Extent: Abuts but confined to the capsule Resection margin: Not involved, grossly (safety margin: 1.5 cm) Remaining parenchyme: Unremarkable, grossly Representative sections are submitted. LO3 'arsnonu, hepatelbuler n1oS Gross photo: Present 817D/3 Blocks Sut. sLive Caac T1-4 and TB, mass of liver x 5 MO 5/9114J RM, mass with resection margin x 1 L and NB, nontumorous liver parenchyme x 2 MICROSCOPIC: Tumor type: Hepatocellular carcinoma Edmondson-Steiner grade The worst: II The major: II Histologic type: Trabecular and tubular Cell type: Hepatic Fatty change: Yes Cholangiocarcinoma: No Fibrous capsule formation: No Septum formation: No Surgical resection margin invasion: No. Serosal invasion: Very close but free of tumor Portal vein invasion: No Vascular invasion: No Bile duct invasion: No Remaining liver parenchyme: Chronic hepatitis Etiology: HBV Grade, lobular: Mild
+
+--- Page 2 ---
+Grade, portoperiportal: Mild Stage (fibrosis): Periportal Cirrhosis: No. NOT reported. Gross: liver,ectomy,hepatocellular carcinoma T56000, P10, M81703 DIAGNOSIS: Liver, right, right posterior sectionectomy: Hepatocellular carcinoma Suggestion : hw 1 1314
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diff --git a/output/text/5fda9646-6f20-49cc-828d-fc2175957464.txt b/output/text/5fda9646-6f20-49cc-828d-fc2175957464.txt
new file mode 100644
index 0000000000000000000000000000000000000000..698b905d30088aca0aade7617e014968ec09b184
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+IeD-O 3 Patient Name: C 74.C Date of Birth:  s113 Sex: Female UUID:345C34EE-F031-41A4-B955-BA054F2A3CE1 CGA-0R-A52-01A-PR Reda Macroscopy Iwo vessels containing a material immersed in formaldehyde solution, described as following: 1 product of en-bloc resection of the left kidney, spleen and left adrenal mass. The mass is totally involved by a fibrous capsule (measuring from 0.1 to 0.7 cm), weights 810 g and measures 18 x 14 x 7 cm. The internal surface is yellow, with areas of fibrosis and necrosis in aproximatelu 25% of the mass. Two cystic areas of 3.0 cm each. The left kidney is macroscopically normal, measures 12 x 5 x 4 cm and weights 150 g. The spleen is macroscopically normal, measures 7 x 4 x 2.5 cm and weights 120 g 2. "Lymph node" resection. Gray nodular structure that macroscopically resembles an accessory spleen. Conclusion: 5|30f 3 pw T3S,tumr achully mW sidL Product of right adrenal mass resection: Adrenocortical carcinoma with the following features: Largest diameter -- 18 cm. Weight-- 810 g Nuclear grade (Fuhrman) --- Diffuse architectural pattern -- Clear cells in  25% of the neoplasm --  Areas on necrosis -- present Mitotic count ---- Atypical mitosis ---- Capsular invasion -- present-
+
+--- Page 2 ---
+ Venous invasion -- present- Sinusoidal invasion -- :) WEISS SCORE = 8 Presence of extra capsular extension Immunohystochemical markers: Melan A -- focally positive .Inhibin -- focally positive. :35BH11 -- focally positive AE1 / AE3  focally positive CD10 -- focally positive  S-100 protein -- positive Vimentin -- positive-  Chromogranin -- negative Synaptophisin - negative Pathologists:
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diff --git a/output/text/5feef0a9-4a92-421b-9fd3-6cfe9b28ace0.txt b/output/text/5feef0a9-4a92-421b-9fd3-6cfe9b28ace0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..df1b9333ade8a60acfdb593868e6bc6ecbbc3be1
--- /dev/null
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+
+--- Page 1 ---
+1C5-0 - 3 Carcinoma, infiltnatrg duitl, N0s 85oo/3 Path S.fe:brot, uIQ C50.2 /251 CQCF Sits: bUast,Nos c5o.9 Diagnosis: Left breast segment (upper medial) with a 1.7 cm well differentiated (G1) invasive ductal breast carcinoma. Carcinoma-free resection margins, carcinoma-free skin. Considering the tumor-free medial follow-up resection material (sample 3), the carcinoma was certainly excised in toto. Tumor stage: pT1c, G1, pL0, pV0, pN0 (0/1, SLN), pR0. JUID:6D2212CE-C80F-4545-A895-3F186E4C6D86 TCGA-A8-A08A-01A-PR Redacted
\ No newline at end of file
diff --git a/output/text/5ff43ee2-e0e4-4102-8760-26b6642a5153.txt b/output/text/5ff43ee2-e0e4-4102-8760-26b6642a5153.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9f3fba768662316205362d600547e796379b7784
--- /dev/null
+++ b/output/text/5ff43ee2-e0e4-4102-8760-26b6642a5153.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:625DE530-9D89-49BD-BA62-A161814A4658 TCGA-2Z-A938-01A-Pr Redacted Pathology Report Cenders Service! Recelved Peported: Submittsng Physiciaca: Fatholog:et:. .ntraop.Patnolcget Fertorming. Phyeician: CLENICAL HISTORY NONEGIVEN FRECPERATIVE DIAGNOSIS: LEFT KIDNEY TR MICROGCOPECHEMATURIA SPECIMEN TYPE(S) A: IITH RIR CHOSS ONLY B POSTERICR MEDIAL CYST WALL rS C LEYT RINALMASS PS FINAL DINGNOGIS: A. Bone wltn hematopclettc atrow no evidence or -altgnancy B. POSTERIOR MEDIAL CYST WALL Vascuiarized r:croadipose clasue witti cnronic inriasmat ion and adjacent. renal parercnyma. No evidence ot mai gnancy. C. LEFT KIONEY, FARTIAL NEPHRECTCMY: Henal cest carcirona, pap:iisry, typa ii. (ece Key Patnologia Findinge! Pathologie.stage: pT15 NX xX ID03 KEY PATHOLCGIC PINDINGS Tumor tyre Renal cel. .carcinork,.pap:llaty, type Is. Nuclear gradeli/iy Patcern ot growtnr* Lnirocai and solid. Tumor aizes. 4cm Renal capeui nvasion Not lentirie. 064.9 naaion o Gercta' Fascfsx .Not apptcsnle. Penal. vein Invasion: Not applicable S0rg1c31 m3rginss Freeo m3gn3ncy HI r11a8|14 Angiolyrpnatic snvssion: Not tdentitled. Fezineural invaa:oni Not idert rted.. Non-ceopiaatic kidney: Jnremarkable Adrenal gland: Hot applicsble Lyuph rodes: Noc applicabie the attending patns cgist, puraonaly reviewed tne ontire pathicgyo case.and rerered the irnl Magnos:s. siectromicaly signed out.ty HRH FELATED CLNICAL. DATAT NA NTRAOPERATIVE DIAGNOSIS FSBL FOSTERICR MEDIAL CYST WALLt Fbrotic tissue with.atypical.cells 3ajacent glomeruus ars crushed tubuies 1dentirled. Deter ca permanert. Requeated more tiasue ls appiicable.
+
+--- Page 2 ---
+OMMENT.Th.frozeD .and.acxncwleged.by ESCI+ LEFT PENAMASS: Renal cerl.carc:noms.. Margins Iraeor tumor SNTRADHPARTMENTAL CONSULTATION: C. OROSS EXAMIRATION, LEFT RENAL MASS Grossiy cumor is Q.s cm crom the xecal parencnymal margin. The closest negative surrace margin ia a thin tiorous, capsule. rave pertcrmedcne intracperative coneultation ard isaued tne.abovediagncsee COOSS DESCRIPTCN The specimen 1s' received trean: in 3 ccntainers. specscen A Ia iabeiej: "iitn H. ribr*Tme apeclnen conaistsor2 urokiented rragments ot rit wnich areranging tcon 3.0 to 3.0 cm An lengtn, with'a smali smount ot adjacent can, rod.brown, sort to nibbery.tisaue. Hoth resection sargina or. cragnencs are grosay unrararkable. Tangential.sect.on or botn resecticn.nargirs aubmdcte1 in 3.cassettes Al and A2, roliowlng decaicscication. Specimen n isIateled *poster.or medial cyst.wali Tne speciren conslsts ot an :rregular, unorzented rragment or tan, red-brcwn rubbery Cisaue measuring 0.6 x. 0.2 x 0.i cn, which. is subaitted entirely tor rrozen section as rsa. C. Specimen C ia Iabeled *lert renal maes.irozen section :or dtagnoeis and margin. Checx. desp margn plus ink margin.pius inked gurtace margin'.. The.epecimen consist ora partial nepnrectcayspecmen whicn is easuring$.x.50x45 cm witn ascderate.amount. ox adjacent to.capsule perinephric adipose tiasue whs:n i ranging rrom o.i to.o.g cm in thicxness. Tae parenchysal resecrion sargin is'tan, red-nrown, groasiy unrazarrabie. me. specimen Ia oriented acoording to t.e Surgegn's des ignation and, inked as Coliows. Parercnysal reaectton sargin nack Rerinephrid adpcsetiaaue regection margin Rue, The apecimen 1a seriaily sectioned to reveal an irregutar to. ovoid, sll-cerined tumor wnion'ia seaauring 4.3 x 4.3 x4.5 cm, The sumcr.is tu ging,tut doeu nor appear to extend.tnrough.the renal.capaale.and witnin Dlc.orte.resecr.on -axgin ot tne perinoprric suipcae.tisaue,Tne tamor groasly0.5cm or tne parencnysi. reaection nargin. The cut 'aurrace.ss tne tumor ia varicgated, tan-pint to tan-red focally necrotic ani nemorrhagic..Representatiye section os tre tunor w.th cloeeat inked black pareuchymal regection margin submitted cor rrozen.section as Fsc. Repxesentativesections br tre specinen submitted.co tne Tiaeue Procurement Laboratory. representative eections ot tne apecimen submitted in 7 cssaettes ag tOllOwE: C1-C2 Aduitional.secticns ot the cunor witn adjacent renal parenchyra -c Centrai part or tne tunor. CS-07 : rumor bu ging capsule. 1314
\ No newline at end of file
diff --git a/output/text/60262ab2-5fd1-4e15-9678-bfcfbed2696a.txt b/output/text/60262ab2-5fd1-4e15-9678-bfcfbed2696a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7a3d2cc0ec985c1c6f84c96f928202a63c0a5c45
--- /dev/null
+++ b/output/text/60262ab2-5fd1-4e15-9678-bfcfbed2696a.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+zD3 Date of surgery :. 877273 Sute O UiLcb93 Left eye enucleation Macroscopy YU3/10/14 The enucleation specimen contains a fragment of optic nerve of 12 mm. There is no visible extrascleral extension. Samples have been made for cryo preservation and for xenografts .The. specimen has been then included entirely. Microscopy Analysis of the specimen shows an intraocular tumor which morphological characteristics are those of a melanoma. The lesion is composed of fusiform cells. The pigment content is moderate. The mitotic index is low (less mitosis by field at the 40 magnification.)There are no necrosis. The lesion is implanted at the posterior pole, covering the emergence of the optic nerve. It measures 13 mm at the basis with 7 mm of thickness. It stays distant from the ciliary processes. At the posterior pole, the optic foramen,the optic nerve and the meningeal sheaths are free. The cut end of the optic nerve is also free. Conclusion Choroidal melanoma with fusiform cells. Size of the tumor: 10 mm Neither involvement of the sclera nor extrascleral extension Ciliary processes, optic foramen and optic nerve are free.. UUID:98EC98E0-F65F-40F7-A499-E9F6C8DF6C020 Redacted TCGA-V4-A9EA-01A-PR hw'p|3o/l33!
\ No newline at end of file
diff --git a/output/text/6047df3b-c073-4a96-9b1a-10d3e605e48f.txt b/output/text/6047df3b-c073-4a96-9b1a-10d3e605e48f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b3b8699022d949e505cf876db0e70b0abd8b3dd4
--- /dev/null
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+
+--- Page 1 ---
+Ics-0-3 17020F6933E enrcinwmn,mfItnutrng duct, Nos 85o0f3 TO-01A-PR Redacted Sire: breast Nos C50.9 Breast, right, simple mastectomy: Infiltrating ductal carcinoma, Nottingham grade III (of III) (tubules 3/3, nuclei 3/3, mitoses 2/3; Nottingham score 8/9], forming a single mass (7.2 x 4.5 x 3.4 cm) located in the upper inner and upper central quadrant of the breast [AJCC pT2]. Angiolymphatic invasion is absent. The non-neoplastic breast parenchyma shows nonproliferative fibrocystic changes. Calcifications are present in malignant ducts. Biopsy site changes are present. All surgical resection margins, including the deep margin, are negative for tumor (minimum tumor free margin, 7.0 cm, deep margin). Breast, right, supranumerary nipple excision: Intradermal nevus (0.6 cm in greatest dimension). Lymph nodes, right axillary, dissection: Multiple (2 of 9) right axillary lymph nodes are positive for metastatic carcinoma. The largest lymph node measures 1.4 cm. No extranodal extension identified Lymph nodes, highest right axillary, dissection: Multiple (6) highest right axillary lymph nodes are negative for tumor. Breast, left, simple mastectomy: Nonproliferative fibrocystic changes. Her-2/NEU has been ordered on paraffin-embedded tissue.
\ No newline at end of file
diff --git a/output/text/60799f84-98b0-49c4-9ebc-02b47fdaf191.txt b/output/text/60799f84-98b0-49c4-9ebc-02b47fdaf191.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a896bff26f9d7286595010a81dde7039122bc717
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+FINAL DIAGNOSIS: Kidney, right, nephrectomy - A. renal. cell carcinoma, conventional (clear cell) type.  fuhrmAn nUcLEAr GraDe IS 2 Of 4 C. ThE CARCINOmA mEa$URES 5.7 CmIN GREATEST DIMENSION. D.  THe cArcInomA Is coNfiNed TO the kIdNey. E. ALL SURGICAL MARGINS OF RESECTION ARE NEGATIVE FOR CARCINOMA. F.  NO EVIDENCE OF ANGIOLYMPHATIC INVASION IS IDENTIFIED. G.  THE NON-NEOPLASTIC KIDNEY SHOW$ CHRONIC INTERSTITIAL iNFLAMMATION AND GLOmeruLOsclerosIs. H.TNm pAthOLOg(C stAGE: pT1b NX mX (SEe synOptiC). CASE SyNopSis: SyNOPTIc DATA - PRImARy KIDNey TUmORS Specimen Type:  Radigal nephrectomy LATERALITY:S Right Tumor site: Upper pole FOCALITY: Unifocai TUMOR SIZE: Greatest dimension: 5.7 cm. Additignal dimensions: 5.3 x 4.5 cm Macroscopic extent Of tumor:  Tumor limited to kidney. HISTOLOGIC Type: Clear dell (conventional) renal carcinoma HISTOLOGIC GRADE (Fuhrman Nuclear Grade): G2 PATHOLOGIC STAGING (pTNm): pT1b pNX  Number of regional lymph nodes examined: 0. pMX MARGINS:  Margin's uninvolved by invasive carcinona Adrenal gLand: Not present LYMPH-VA$CULAR INVASIQN (LVI): Absent/not identified ADditional Pathologic Findings:  Inflammation (type): Chronic interstitial inflammation Glometular disease (type): Glomerulosclerosis KIDNEY-RESIDUAL TUMOR (R): RO
\ No newline at end of file
diff --git a/output/text/608500d1-3636-44d8-b44f-1d0ac9b5db48.txt b/output/text/608500d1-3636-44d8-b44f-1d0ac9b5db48.txt
new file mode 100644
index 0000000000000000000000000000000000000000..654c84ca48820e75f3ae8b752da7fccee24bde0e
--- /dev/null
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+1cs-0-3 Carcinomr,lnfiltnsHng dutf NUs 85oo/3 fash Site: brest, yoQ C5o.y. 1/s5|n lu CQ cF Sife: bresst,nss c5o.9. Diagnosis: 1. Moderately differentiated invasive ductalcarcinoma (tumor diameter: 8 cm) Distance to dorsal resection margin less than 0.1 cm.. Concluding tumor classification for the right breast: NOS, G II, pT3L0V0RX. UUID:956F45E5-A8C6-4A4A-9D1F-D31912180584 TCGA-A8-A06Z-01A-PR Redacted
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diff --git a/output/text/610f25ed-09aa-4f29-ad65-f9b9d37eec34.txt b/output/text/610f25ed-09aa-4f29-ad65-f9b9d37eec34.txt
new file mode 100644
index 0000000000000000000000000000000000000000..93cca171902c005269c9b835db04f6462e4c8f2e
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+--- Page 1 ---
+Requesting Doctor's Intormatlon: UUID: 32888F7A-8CEC-4670-A83F-B16AF53E74CE TCGA-OR-A5C-01A-PR Redacted tcd-o-3 orcinsina, adreual eortica! Site:CAdrenasgtand A SPECIMEN TYPE: Adrenal Mass Cs^+eQ C74.D T 1Qg/i3 CLINICAL NOTES: H L) adrenal tumour -> gynaecomastia. 0 MACROSCOPIC: L "Left adrenal tumour." The specimen consists ot a lobulated, roughly ovoid 0 mass, 135 x 100 x 90mm, weighing 754g. The specimen has been previously incised prior to receipt over a length of 45mm. The mass is lobulated and. G surrounded by a thin layer of adipose tissue. On sectioning, lobules of tan Y tissue are separated by fine fibrous bands. Areas of haemorrhage and necrosis are identified. Most of the tumour is light brown/tan. Small amounts of residual adrenal gland parenchyma are present at the peripheries.. Representative tissue smbedded in six blocks. MICROSCOPIC: The adrenal tumour is a high grade adrenal cortical carcinoma. The tumour is variable in its architecture, including diffuse sheets, areas of glandular, papillary and trabeculae formation, and regions where the cells are more. insular in their arrangement. There are occasional well differentlated areas where the tumour vaguely resembles normal adrenal cortical parenchyma. The A cells have abundant granular eosinophilic cytoplasm with clear cell areas.. N Nuclear pleomorphism is variabie and overall moderate. There is a rich vascular background with large areas of haemorrhage and necrosis. Mitoses are numerous, A Including atypical forms, up to 24/50 hpf. T There is prominent vascular space permeation within capsular vessels, showing formation ot tumour thrombi. 0 A thick tibrous capsule surrounds the tumour and local resection appears M complete. A rim of atrophic adrenal cortex is seen at one end. 1 SUMMARY: c Left adrenal mass: A High grade adrenal cortical carcinoma, with prominent vascular space  permeation. L Local excision appears complete. T-93000 M-80103 P A T H 0 L n
+
+--- Page 2 ---
+ Requesting Doctor's information: H s T 0 p A T SPECIMEN TYPE: Adrenal Mass h 0 REPORTING PATHOLOGIST: (Electronic Signature) L 0 G Y A N A T 0 M 1 c A L P A T H 0 L 0 Page 2 of 2 G Y
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diff --git a/output/text/613a38b9-3ffd-4994-929f-1cd36494d727.txt b/output/text/613a38b9-3ffd-4994-929f-1cd36494d727.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6ba16daab8eabfe5325c589606951184416adda0
--- /dev/null
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+
+--- Page 1 ---
+UUID:6AC8C0C6-A43A-427E-90D3-6584FC2F723E TCgA-C5-A907-01A-PR Redacted SURG PATH.FINAL REPORT Locatior Addresnaa Phone....... Patlent Information patlemName..*. Sex DOR Phone Female Patient Rslease Status: This result is not viewable by the patient. Collection Information ResuungAgency Entry Date Component Results Componerit . Value SURG PATH FINAL icd -o -3 REPORT 8070L3 Sule Iwrriy NOs C 53.9 Accession #: 1/21/14) Specimen: Date of Procedure: Performing Clinician: A. Anterior cervix Posterior cervix Diagno. At Biopsy: -Superficial fragments of squamous cell caroinoma-(see comment). cOMMENr: The specimen is tangentially sectioned, with insufficient strama to evaluate for invasion. B. Posterior cervix, biopsy: - Invasive squamous cell carcinoma, moderate to poorly differentiated (see comment). COMMENT: The tissue is tangentially sectioned precluding accurate evaluation of the depth of invasion.  The carcinoma is at least superficially invasive. Clinical correlation is Printed by
+
+--- Page 2 ---
+Encounter Date: recommended. MD Electronically siamed by Verified: Gross: A. The specimen is labeled "ant". Received in formalin is a 0.6 x 0.6 x 0.2 cm fragmented portion of tan-gray tissue. The specimen is submitted in toto in cassette A. B. The specimen is labeled "posterior lip of cervix". Received in formalin is a.0.5 x 0.5 x 0.2 cm aggregate of firm tan tissue and clotted blood. The specimen is submitted in toto in cassette B. Accession #: Microscopic: A histologic examination has been performed. Administrative Notes:. CPT: No charge codes are associated with this case. Result History  SURG PATH FINAL REPORT (Order  Order Result History Report.. Lab Information ResultinoAgency. Lab Collection Information Colleotion Data and Time IDs Order#. Specimen# Printed by
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diff --git a/output/text/613a38ea-bc91-489d-bc6c-26c814684f08.txt b/output/text/613a38ea-bc91-489d-bc6c-26c814684f08.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c925cf817f970da14a7269da05a96fecbe113ae6
--- /dev/null
+++ b/output/text/613a38ea-bc91-489d-bc6c-26c814684f08.txt
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+
+--- Page 1 ---
+Diagnosis: In I), there is a benign lesion in the sense of a hyperplastic polyp. in II) is an adenocarcinoma of the colon (Block A) of poor differentiation with infiltration of the muscularis and vessels (G3, pT2, L1, V1). Tumor classification: ICDO-DA M8140/3 G3 pT2, L1, V1, pN0 (0 of 12), locally R0
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diff --git a/output/text/616b000a-853b-45ee-9e4c-bc3613514098.txt b/output/text/616b000a-853b-45ee-9e4c-bc3613514098.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9b21c87cc32fbc18b9a3c38a4f32ca737983284b
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:B98EC873-CB6D-4395-A473-C46EC4D2DB00 TCGA-PK-A5HA-01A-PR Redacted LABORATORY MEDICINE PROGRAM zLD t-3 Carcinoma.. Adrenal Cortia) 8370/3 S,+e, C Adrenal Cland,cor tey C74. D 4) 1/8/13 Surgical Pathology Consultation Report Patient Name: Accession #: MRN: Service: Colfected: DOB: Visit #: Received: Gender. M Location: Reported: HCN: Facility: Ordering MD: Copy To: Specimen(s) Received 1. Adrenal: resection adrenal mass left 2. Fat Diagnosis 1. Adrenal cortical carcinoma: Adrenat No pathological diagnosis: Lymph node, periadrenal - (left) adrenalectomy specimen 2. No pathological diagnosis: Adipose tissue, (site not listed) excisional biopsy Comment The morphological and immunohistochemical features are consistent with an adrenocortical carcinoma Synoptic Data Neoadjuvant Therapy: No Clinical History: Other: left side pain. Tumor Site: Adrenal structure Adrenal Gland Received: Fresh Procedure: Adrenalectomy, total Specimen Integrity: Intact Specimen Size: Greatest dimension: 7.0 cm Additional dimension: 6.0 cm Additiona! dimension: 5.0 cm. Specimen Laterality: Left Tumor Size: Greatest dimension: 5.0 cm Additional dimension: 4.4 cm. Additional dimension: 4.0 cm. Tumor gland weight: 47.3 g Histologic Type: Adrenal cortical carcinoma Margins: Margins uninvolved by tumor Treatment Effect: Not identified Lymph-Vascular Invasion: Present, small vessel (capillary lymphatic) Perineural Invasion: Not identified Ancillary Studies: Types: IHC Resuits: The tumor is strongly positive for calretinin, synaptophysin and Melan A (A103). There is variable positivity for LMWK (CAM 5.2), inhibin, CD10 Page 1 of 2
+
+--- Page 2 ---
+Surgical Pathology Consultation Report (cytoplasmic) and p53. Stains for EMA, S100, and chromogranin are negative.. MIB-1 Ll is 20%. TNM Descriptors: Not applicable Primary Tumor (pT): pT1: Tumor 5 cm or less in greatest dimension, no extra-adrenal invasion. Regional Lymph Nodes (pN): pN0: No regional lymph node metastasis Number of Nodes examined: 1 Number of Nodes involved: 0 Distant Metastasis (pM): Not applicable Additional Pathologic Findings: Tumor necrosis Degenerative changes, Hemorrhage *Pathologic Staging is based on AJCC/UICC TNM, 7th Edition Electronically verified by: Clinical History Left adrenal adenoma Gross Description 1. The specimen labeled with the patient's name and as "resection adrenal gland rmass left" contains an adrenal gland. with surrounding fibroadipose tissue. The specimen measures 7.0 x 6 .0 x 5.0 cm and weighs 70.2 g. The surface is painted with silver nitrate and the fat is removed. The adrenal gland measures 5.2 x 4.0 x 5.0 cm and weighs 47.3 g. On. section, there is a well-circumscribed multilobulated mass that measures 4.4 x 4.0 x 5.0 cm. The cut surface of the tumor. has a variegated light brown to tan color, solid and firm. The rest of the adrenal tissue is unremarkable grossly. The tumor. and normal tissue are stored frozen. The adrenal tissue is submitted as follows:. 1A-AG adrenal gland serially sectioned and submitted in toto 2. The specimen labeled with the patient's name and as "fat' contains a single piece of a grossly unremarkable fibroadipose tissue that measures 5.5 x 2.2 x 1.7 cm.. 2A representative sections MICrostup ;rlption Fuhrman Nuclear Grade: IV Necrosis: Present, predominantiy single cell necrosis. Mitotic activity: >5 mitoses /50 high power fields. Atypical mitosis: Present Growth pattern: Solid and diffuse Cell type: Eosinophilic, > %90 Lymphovascular invasion: Present, sinusoidal type. Capsule invasion: Present, focal Immunohistochemistry: The tumor is strongly positive for calretinin, synaptophysin and Melan A (A103). There is variable. positivity for LMWK (CAM 5.2), inhibin, CD10 (cytoplasmic) and p53. Stains for EMA, S100, and chromogranin are negative. MIB-1 LI is 20%. Page 2 of 2
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diff --git a/output/text/61743638-9ef6-4250-985d-20056d919d1b.txt b/output/text/61743638-9ef6-4250-985d-20056d919d1b.txt
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index 0000000000000000000000000000000000000000..8b4eb6e6ce3fee0594d57459ff7e8ace63a2a4d5
--- /dev/null
+++ b/output/text/61743638-9ef6-4250-985d-20056d919d1b.txt
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+
+--- Page 1 ---
+LCD-6 3 Carcnomd,/ynaI cell SURGICAL PATHOLOGY Chomsphobe tyee. 88/7|3 Case Number : Sute E4isrey ngS 'C649 Diagnosis: 8/9/ 3 A: Base of tumor, excision. - Renal cell carcinoma, chromophobe type - Fuhrman grade 3 of 4 B: Left renal mass, partial nephrectomy Histologic tumor type/subtype: renal cell carcinoma, chromophobe type; see comment. Sarcomatoid features: None identified. Histologic grade (if applicable): Fuhrman grade 3 of 4 Tumor size (greatest dimension): 3.7 cm Tumor focality: Unifocal. Extent of tumor invasion (if present specify if macroscopic or microscopic): Capsular invasion/perirenal adipose tissue: Negative for. malignancy Gerota' s fascia: Negative for malignancy. Venous (large vessel): Not identified. Lymphatic (small vessel): Not identified Histologic assessment of surgical margins:. Renal parenchymal margin (partial nephrectomy only): Tumor involves inked surgical margin (B1). Renal capsular margin (partial nephrectomy only): Negative, but close; tumor is < 1 mm from the inked capsular margin Paranephric adipose tissue margin (partial nephrectomy only): Negative for malignancy. UUID:1BBCA936-0E8A-4485-A26E-EA998B326F54 TCGA-UW-A72K-01A-PR Redacted Adrenal gland: Not sampled. Lymph nodes: Not sampled. AJcc Staging: pT1a pNX
+
+--- Page 2 ---
+This staging information is based on information available at the time of this report, and is subject to change pending clinical.review.and additional information.. Comment: Immunohistochemical stains are performed and demonstrate the tumor is diffusely positive for ck7, cDi0, E-Cadherin, and cD117 while being negative for Rcc and vimentin. This immunophenotype, combined with the histologic features, is most consistent with the chromophobe variant of renal cell carcinoma.. Clinical History: -year-old male with a left renal mass. Gross Description: Received are two appropriately labeled containers.. Container A is additionally labeled "base of tumor." It one tan/gray soft tissue mass measuring 1.0 x 0.7 x 0.4 cm. The tissue is submitted in block Al, Container B is additionally labeled "left renal mass." It holds a partial nephrectomy specimen weighing 34.2 grams and measuring 5.4 x 4.7 x 3.5 cm overall. The kidney parenchymal margin is inked in black and the capsule overlying the mass is inked blue. Sectioning reveals a fairly well circumscribed mass measuring 3.7 x 3.3 x 2.4 cm. The capsule overlying the mass appears to be intact. The cut surface of the mass is tan/pink and there appears to be a small amount of residual tan/white kidney at the parenchymal margin. The tumor is grossly 0.2 cm from the black inked parenchymal margin. Block Summary: B1-B3 - mass with black inked parenchymal margin. B4-B5 - mass with overlying blue inked capsule B6 - additional sections of mass lu 7f 30f13
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diff --git a/output/text/619f2cb7-49cc-4195-a39a-dc0f138717de.txt b/output/text/619f2cb7-49cc-4195-a39a-dc0f138717de.txt
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index 0000000000000000000000000000000000000000..399d27bae5f591b218501fbd251b764fb0026afe
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+
+--- Page 1 ---
+IDe3 8qb013  UUID:2B03AFA2-8EF4-4E67-95A0-0E0B0885F168 Redacted Sute : C Yudrey Ngs ^C64.9 FtJ b|13|14 Pathology report communicated verbally over the phone. 1.2 cm diameter, papillary, well differentiated Renal Cell Carcinoma (Type II) Grade: GI/GII Stage: pT1a, R0 Latralsh hw s|lf1y
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diff --git a/output/text/61b26efd-4b49-4809-975c-9da6f60ce8f8.txt b/output/text/61b26efd-4b49-4809-975c-9da6f60ce8f8.txt
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index 0000000000000000000000000000000000000000..09f34c977e168e70d0af060beff83368271ae861
--- /dev/null
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+
+--- Page 1 ---
+SURGICAL PATHOLOGY REPORT Clinical. Diagnosis & History:. with hepatic flexure mass biopsy adenoma. Specimens Submitted: 1: Sp: Right colectomy DIAGNOSIS: 1) RIGHT COLON; RIGHT HEMICOLECTOMY:S - INVASIVE ADENOCARCINOMA, POORLY DIFFERENTIATED, WITH MUCINOUS AND MEDULLARY FEATURES. TUMOR LOCATION: ASCENDING COLON. TUMOR SIZE: LENGTH IS 7.1 CM, WIDTH IS 5.5 CM AND MAXIMAL THICKNESS IS 0.5 CM GROSS CONFIGURATION: ULCERATING INFILTRATIVE. PREEXISTING POLYP (AT THE SITE OF THE CARCINOMA) : NOT IDENTIFIED. TUMOR INVASION: INVASION INTO SUBSEROSA. GROSS TOMOR PERFORATION: NOT IDENTIFIED. SEROSAL INVOLVEMENT: NOT IDENTIFIED VASCULAR INVASION: SUSPECTED, PERINEURAL INVASION: NOT IDENTIFIED SURGICAL MARGINS: FREE OF TUMOR. NOT IDENTIFIED. -POLYPS (AWAY FROM THE CARCINOMA: UNREMARKABLE. - NON-NEOPLASTIC BOWEL AND APPENDIX: pT3 THE PATHOLOGIC STAGE IS AJCC 2O02): - LYMPH NODES: NUMBER WITH METASTASES (O); NUMBER EXAMINED (27). - THE PATHOLOGIC STAGE IS (AJCC 2002): pNO I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT.
+
+--- Page 2 ---
+Page 2 of 3 1). The specimen is received Eresh, labeled "right colectomy" and consists. of a segment of terminal ileum (10 cm long x 4 cm diameter), cecum and ascending colon (23 cm long x 5 to 9 cm diameter), appendix (4.5 cm long x) 0.4 to 2 cm diameter) and attached adipose tissue / omentum (23 x 23 x 1.5 cm). The appendiceal and intestinal serosa is pink tan and smooth. The appendix contains a 2 cm fecalith and shows a normal mucosal surface. The The specimen is opened to reveal a and located 12 cm and 16 cm from the distal and proximal resection margins, respectively. The lesion is centrally necrotic with a heaped-up border, is firm and tan-yellow. It spares the ileocecal valve and appendiceal orifice. by 4.5 and 5.2 cm, respectively. Sectioning shows the tumor to extend into the muscularis propria and possibly beyond it, into the pericolonic adipose tissue. In this area, the serosa is puckered (inked black).. The depth of invasion is approximately 0.5 cm in the ulcerated center. The remaining mucosa is normal.  The specimen is submitted for lymph node disseotion and all identified lymph nodes in the attached adipose tissue are submitted. Representative sections of the specimen are submitted for permanent sections. and for Summary of sections: p-- proximal margin shave D -- distal margin shave M-- mass, representative Ms .- mass to puckered serosal surtace, representative. A -- appendix, representative ICV ileocecal valve, representative colon, representative I -. ilewn, representative LN-- lymph  nodes Sunmary of Sections: Part 1: SP: Right colectomy Block Sect. Site PC8 2 A 2 c 3 1 D 1 1 1 ICV 1 10 LN 20 M 3 MS 3 P 1 1 ** Continued on next page
+
+--- Page 3 ---
+Page 3 of 3 * End of Report *
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diff --git a/output/text/61f037c1-64d3-4178-a344-b830b05b5d2d.txt b/output/text/61f037c1-64d3-4178-a344-b830b05b5d2d.txt
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index 0000000000000000000000000000000000000000..4766a0a758656014557c474637c04146550dbe78
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+
+--- Page 1 ---
+/cs-0-3 CarCinoma,rifiltnating dluctal Nos 85oo/3 91/28fn h s,te: breast,Ns C50.9 ID#: Pathology Form Specimen Information Collected by: Preserved by: Date; Fime., *+aSPECIMENTYPE (#of samples provided)** Frozen  Paraffin Block Blood/Serum/Plasma Slide Diseased  Normal Diseased  Normal Diseased Normal Diseased  Norma! 2 4 2 4 Z Time to LN2 Time to Formalin Time to LN2 42. min 13 min min Dw. SSPATHOLOGICAEDESCRIPTIONA Primary Tumor Organ Size  Extension of Tumor Distance to NAT Breaet lismor 6 xS x4.cm cm Lymph Nodes Location # Examined # Metastasized Distant Metastasis  Organ Detailed Location Size Pathological Staging pT 3 N 2 m O Stage:I F Notes: ARexcT'p:ocles 8 qeu 2 ejcl's:(Hj p1) 3reasT noles in Nite UUID : 3E24D3A0-9741-4635-89DB-EED4BA3F6AAA TCGA-C8-A130-01A-PR Redacted
+
+--- Page 2 ---
+:D#: Microscopic Description nwHistologicalPattern.www Cell Distribution + Structural Pattern  Diffuse S  Streaming  Mosaic  Storiform  Necrosis Fibrosis Lymphocytic Infiltration  Palisading Vascular Invasion  Cystic Degeneration  Bleeding Clusterized  Alveolar Formation  Myxoid Change  Indian File  Psammoma/Calcification Cellular Differentiation Sarcomatous + Lymphomatous Adenomatous + + Squamous +  Squamoid Cell Glandular cel! Round Cell  Large Cell Cell Stratification  Fibroblast Small Cell Spindle Cell  Keratin Osteoblast RS Cell/RS Like  Secretion  Lipoblast Inflam. Cell  Desmosome Intracyt. Vacuole  Gland formation Myoblast  Plasma Cell  Pear! Well Moderate Poor  Cellular Differentiation: wwNuclearAppearancehewwwr 0 1 1I III Nuclear Atypia: Y  Aniso Nucleosis Hyperchromatism  Nucleolar Prominent Muitinucleated Giant Cell Mitotic Activity Nuclear Grade: Datae Value Date Marker Result ER  Negative   Positive PR  Negative  Positive Her-2/neu  Negative  Positive  Negative  Positive B-Cell Marker  Negative  Positive T-Cell Marker  Negative  Positive Other: Other:  Negative  Positive Final Pathology Report Histological Diagnosis: Grade: Comments: 1ReosTnodeg B ( pA'Tive B, Negcil:ve C Date Pathologist Principal Investigator 5
+
+--- Page 3 ---
+COnsOlIDated DIagnostic patholOgy foRm* Microscopic Appearance:d Histological pattern: CELL DISTRIBUTIONS + STRUCTURAL PATTERN Diffuse Streaming. Mosaic  Storiform Necrosis Fibrosis Lymphocytic Infiltration  Palisading Vascular Invasion Cystic Degeneration Clusterized X  Blecding Alveolar Formation MMyxoid Change Indian File Psammoma/Calcification 2. Cellular features. Squamous + Adenomstous  Sarcomatous +  Lymphomatous  Squamoid Cell Glandular cell r Round Cell Large Cell Spindle Cell Cell Stratification Fibroblast Small Cell  Keratin Secretion Osteoblast RS CeIl/RS Like  Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell Pear! Gland formation Myoblast Plasma Cell Otherwise Specified: Caueee DL 9SZ Dr7OZ Dz Zo% Sy ZOZ 2.  Cellular Differentiation: Well Moderately Poor Y Nuclear Atypia:  Nuclear Appearance Aniso Nucleosis Hyperchromatism  Nucleolar Prominentd Multinucleated Giant Cell Mitotic Activity Nuckear Grade Histological Diagnosis: ?y/to4/ Due/g/ CaonAo rs, 3 Comments:n MjMr : Caotinsa metasksi3ed to LN Date Director, Research Pathology ) PATHOLOGIST STAFF FOR RESEARCH USE ONLY). (INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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diff --git a/output/text/620fb2ad-73da-474b-baef-c585170d85eb.txt b/output/text/620fb2ad-73da-474b-baef-c585170d85eb.txt
new file mode 100644
index 0000000000000000000000000000000000000000..937fadebe314eb8e5ed0da8396a318b70c520500
--- /dev/null
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@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+Clinical Diagnosis & History ylo female with large right mass disease,for work up of abdominal pain.Imaging suggestive of renal vein tumor thrombus. Specimens Submitted: 1:SP:Kidney,right radical nephrectomy 2:SP:Lymph node,paracaval/retrocaval,excision 3:SP:Adrenal gland,right,adrenalectomy 4:SP:Lymph node,interaortic-caval/pre-aorticexcision 5:SP:Lymph node,para-aortic,excision DIAGNOSIS: SP:Kidney,right, radical nephrectomy Tumor Type: Renal cell carcinoma -Chromophobe type with marked epithelial anaplastic features Tumor Size: Greatest diameter is 12 cm. Local Invasion (for renal cortical types): Tumor extensively replaces the region of the renal sinus/hilum and focally invading the proximal ureteral wall Renal Vein Invasion Identified Multiple other small to medium size vessels in tne renalsinus also show invasion by tumor Surgical Margins: Free oftumor Non-Neoplastic Kidney Unremarkable Adrenal Gland: Not identified Lymph Nodes: Not identified Stagingfor renal cell carcinoma/oncocytoma: pT3b Tumor grossly extends into the renal vein(s) or vena cava below the diaphragm 2.SP:Lymph node,paracaval/retrocaval,excision Lymph Nodes: Page 1of4
+
+--- Page 2 ---
+Number of nodes examined:15 Number of metastatic nodes:3 The largest metastatic node is 0.8cm Perinodal (extracapsular) extension not identified 3.SP:Adrenal gland,right,adrenalectomy Benign adrenal gland 4. SP:Lymph node,interaortic-caval/pre-aortic, excision Lymph Nodes: Number of nodes examined:7 Number of metastatic nodes:1 The largest metastatic node is 0.75cm Perinodal (extracapsular) extension not identified 5.SP:Lymph node para-aorticexcision Lymph Nodes: Not involved Number of nodes examined:4 IATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL)AND THAT IHAVE REVIEWEDANDAPPROVEDTHIS REPORT. Special Studies: Result Special Stain Comment RECUT RECUT RECUT MIB-1Ki-67 MIB-1Ki-67 IMM RECUT NEGCONT IMM RECUT NEGCONT Gross Description: 1).The specimen is received fresh, labeled right kidney" and consists of a kidney with attached ureter, renal vessels and perinephric fat weighing 761g in total.The kidney measures 15 x 12 x 6 cm.The attached ureter measures 9 cm in length and 0.5 cm in diameter.The attached renal vein measures 1.2 cm in length and 1.5 cm in diameter. The vein is occluded by a soft tan mass.The renal ureter margins are grossly unremarkable. An adrenal gland is not identified.The kidney is inked black and bivalved to reveal a 12.0x 11.5 x 5.0 cm multi lobular mass,obliterating the entire renal sinus,and abutting the capsule. The cut surface of the mass is tan yellow with area of hemorrhage and necrosis.Sections through the small remainder of the kidney reveal a pink brown parenchyma.The cortex measures 0.7 cm and the calyces appear invaded by the tumor.Representative sections are submitted for TPS and for permanent sections. Photograph has been taken. Summary of sections UVM-- ureteral and vessel margins VT-renal vein and thrombus Page2of4
+
+--- Page 3 ---
+SURGICAL PATHOLOGYREPORT Ttumor TC-tumor and capsule TSF-- tumor with hilar fat THF--tumor with sinus fat TK--tumor with adjacent kidney RP-- renal pelvis representative sections 2). The specimen is received in formalin, labeled "Paracaval/retrocaval lymph nodes" and consists of multiple pink tan firm lymph nodes ranging from 0.5 to 1.5 cm in greatest dimension. Representative sectioning of each lymph nodes are submitted Summary of sections: LN-lymph nodes 3).The specimen is received in formalin labeled,Right adrenal glandand consists of a resected adrenal gland measuring 2.9 x 1.6 x 0.6 cm and weighing 9 g after fixation. The specimen is serially sectioned to reveal a yellow tan fish flesh cut surface.Representative section are submitted. Summary of sections: A-adrenalgland 4). The specimen is received in formalin,labeled "Interaortic-caval lymph nodes and pre-aortic lymph nodes"and consists of multiple pink tan firm lymph nodes ranging from 0.5 to 2.1 cm in greatest dimension.Representative sectioning of each lymph node is submitted. Summary of sections LN- lymph nodes 5).The specimen is received in formalin, labeled Para-aortic nodes" and consists of multiple pink tan firm lymph nodes ranging from 0.3 to 0.5 cm in greatest dimension.Representative sectioning of each lymph node is submitted. Summary of sections: LN--lymph nodes Summary of Sections: Part 1:SP:Kidney,right,radical nephrectomy Block Sect.Site PCs 2 rp 2 6 t 6 4 tc 4 2 thf 2 2 tk 2 2 tsf 2 1 uvm 1 1 vt 1 Part 2:SP:Lymph node,paracaval/retrocaval,excision Block Sect.Site PCs 9 LN 10 Part 3:SP:Adrenal gland,rightadrenalectomy Block Sect.Site PCs 6 A 6 Page3of4
+
+--- Page 4 ---
+SURGICAL PATHOLOGY REPORT Part 4:SP:Lymph node,interaortic-caval/pre-aorticexcision Block Sect.Site PCs 4 LN 7 Part 5:SP:Lymph node,para-aortic,excision Block Sect.Site PCs 2 LN 2 Page 4of4 ENDOF REPORT
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diff --git a/output/text/6214f574-2153-4596-a731-436fca95d172.txt b/output/text/6214f574-2153-4596-a731-436fca95d172.txt
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index 0000000000000000000000000000000000000000..850992c327d115e3a02ad712ba2bc45e6f42aa19
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+
+--- Page 1 ---
+7C79CF14-EF5F-45BF-A848-14897F1AC3DE TCGA-2Z-A93R-01A-PR Redacted Pathology Report Final Diagnosis A. RIGHT KIDNEY,PARTIALNEPHRECTOMY: Renal cell carcinoma, papillary type ll. See Key Pathologic Findings.. Surgical margin, free of malignancy. Pathologic stage: pT1a NX MX. 8. DEEP MARGIN: Renal parenchyma, no evidence of malignancy.. I the attending pathologist, personally reviewed all. siides and / or materials and rendered the final diagnosis. Electronically Signed out by Ied03 Key Pathological Findings A: Kidney Resection PROCEDURE: 8Q60/3 Partial nephrectomy SPECIMEN LATERALITY: Right C64.9 TUMOR siZE (largest tumor if multiple): Dimension: 2.8 cm MACROSCOPIC EXTENT OF TUMOR: tJ 4/28J14 Tumor limited to kidney HISTOLOGIC TYPE: Papillary renal cell carcinoma SARCOMATOID FEATURES: Not identified TUMOR NECROSIS:  5% HISTOLOGIC GRADE (Fuhrman Nuclear Grade): II-III, predominantly III MICROSCOPIC TUMOR EXTENSION: Tumor limited to kidney MARGINS:  Margins uninvolved by carcinoma ADRENAL GLAND: Not present PERINEURAL INVASION: Absent ANGIOLYMPHATIC INVASION: Absent LYMPH-VASCULAR INVASION: Absent
+
+--- Page 2 ---
+PRIMARY TUMOR (pT): pT1a:Tumor 4 cm or less in greatest dimension, limited to the kidney REGIONAL LYMPH NODES (pN): pNX: Regional lymph nodes cannot be assessed DISTANT METASTASIS (pM): pMX Specimen(s) Received RIGHT PARTIAL NEPHRECTOMY FS B DEEP MARGIN FS Clinical History RIGHT RENAL MASS Preoperative Diagnosis RIGHT RENAL MASS Intraoperative Consultation FSA1. RIGHT PARTIAL NEPHRECTOMY: Renal cell carcinoma. FSB1. DEEP MARGIN: Negative for carcinoma.. Comment: This frozen section diagnosis/result was communicated to and acknowledged by Dr M.D., have performed the intraoperative consultation(s) and issued the above diagnosis. Gross Description A. Specimen A is received fresh labeled *right partial nephrectamy ink is margin." The specimen consists of a partial nephrectomy measuring 3.9 x 2.8 x 2.9 cm weighing 13.1 g. The specimen is. oriented according to the surgeon's designation and is inked as follows: Parenchymal resection margin inked: Blue Renal capsule is inked: Blacke On sectioning the specimen reveals and irregular ill-defined rubbery intraparenchymal solid tumor. which measures 2.8 x 2.5 x 2.4 cm.The tumor bulges the renal capsule and extends to within 0.3 cm of the closest parenchynal resection margin. Cut surface of the tumor is pale yellow to tan brown focally hemorrhagic. Representative section of the tumor in relation to the closest parenchymal resection margin is submitted for frozen section as FSA1. Representative sections ot the specimen. are submitted to the Tissue Procurement Laboratory.Additional sections of the specimen are submitted in 8 cassettes as follows A2-A9: Tumor with adjacent and involved renal parenchyma and overlying renal capsule.d 8. Specimen B received fresh labeled *deep margin, ink is margin." The specimen consists of an irregular oriented fragment of renal parenchyma measuring 1.7 x 1.2 x 0.7 cm. The specimen is oriented according to the surgeon's designation and the new parenchymal resection margin is re-inked. black. The specimen is serially sectioned and is submitted entirely for frozen section as FSB1. 1/3/14
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diff --git a/output/text/62406fb6-d97e-45a6-bf9e-bd8887d4ec56.txt b/output/text/62406fb6-d97e-45a6-bf9e-bd8887d4ec56.txt
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index 0000000000000000000000000000000000000000..ba303ee7fe2b504d36db6fdf47350e534261e10d
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+* Final Report Clinical History Right renal mass Specimen #1 Right kidney Gross Examination  Received fresh, placed in formalin and labeled right kidney is a 16.o x 9.5 x 6.0 cm nephrectomy specimen.  The specimen consists of a 358.7 gram, 13.0 x 8.5 x 5.5 cm kidney with attached perinephric adipose tissue and a 9.0 cm. long, 0.3 cm in diameter ureter. The adrenal gland is not present. Within the. upper to mid pole of the kidney is an 8.0 x 8.0 x 5.0 cm relatively. circumscribed mass. The mass has a soft, friable, variegated golden-yellow to dull yellow and focally hemorrhagic cut surface..  The mass is also focally calcified. The mass abuts and pushes against the renal capsule, but grossly. does not appear to extend through it, and comes to within 0.2-o.3 cm of the. radial soft tissue margin (inked black). The mass is at least 2.5 cm from the vascular margins. The parenchyma is otherwise maroon-tan with a distinct. corticomedullary junction (cortex 0.7 cm and medulla 1.2 cm). There are no. additional lesions identified.  There are no lymph node candidates identified at. the hilum..  The perinephric adipose tissue is serially sectioned to demonstrate. no gross focal mass or lesion.  Following the written consent of the patient fresh tissue is submitted to the and the. Summary: "A", vascular and ureteral margins, tangential; "b", mass with respect to the renal capsule and radial margin, perpendicular; "c", additional section of mass with respect to adjacent kidney and renal capsule; nasswith respect to the pelvic adipose tissue; "g", uninvolved parenchyma. Microscopic Examination #1 Microscopic examination performed. Comment This case has been  reviewed in consultation with one additional departmental. pathologist. Printed by: Page 1 of 2 Printed on: (Continued)
+
+--- Page 2 ---
+Signature Line Final Diagnosis RIGHT KIDNEY: PAPILLARY RENAL CELL CARCINOMA (TYPE 1). #1 TUMOR SIZE: 8.0 X 8.0 X 5.0 CM SARCOMATOID FEATURES: ABSENT. TUMOR NECROSIS: PRESENT. HISTOLOGIC GRADE (FUHRMAN NUCLEAR GRADE) : II. EXTENT OF TUMOR: TUMOR LIMITED TO KIDNEY. LYMPH VASCULAR INVASION: ABSENT. RENAL VEIN MARGIN STATUS: NEGATIVE. RENAL SINUS STATUS: NEGATIVE. RENAL CAPSULE STATUS:  NEGATIVE. PERINEPHRIC ADIPOSE TISSUE STATUS: NEGATIVE. URETER MARGIN STATUS: NEGATIVE (>9 CM). ADRENAL GLAND: NOT IDENTIFIED. ADDITIONAL PATHOLOGIC FINDINGS:  NONE IDENTIFIED. LYMPH NODE STATUS:  PERIRENAL LYMPH NODES NOT IDENTIFIED. PATHOLOGIC STAGE (TNM CLASSIFICATION) : pT2a pNX. Ordering Provider Ordering Physician: Printed by: Page 2 of 2 (End of Report) Printed on:
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diff --git a/output/text/624f633f-b5c1-4dd6-878c-a0f5290a43ed.txt b/output/text/624f633f-b5c1-4dd6-878c-a0f5290a43ed.txt
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index 0000000000000000000000000000000000000000..99df2b3e397718789041faee5ee2e28bc785f531
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+Procurement Date Laterality:Right Path Report:BREAST TISSUE CHECKLIST Specimen type: Radical mastectomy Specimen size: Not specified Tumor site: Breast Tumor size: 5.2 x 5.2 x 5.2 cm Grossly evident lesion: Yes Histologic type: Lobular carcinoma Histologic grade: Tumor extent: Not specified Lymph nodes: 22/22 positive for metastasis (Axillares 22/22) Extracapsular invasion of the lymph nodes: Not specified UUID:FE3E1376-1527-42C0-8F5F-8849D0F27438 TCGA-E9-A3Q9-01A-PR Redacted Margins: Not specified  Nottingham Histologic Score ICD-O-3 Tubule formation: Not specified carCin0ma, in5irahng lObwIar,NO S Nuclear pleomorphism: Not specified 8520J3 Mitotic count (25x): Not specified Sit: Breast,N0s C50.9 Mitotic count (40x): Not specified 2Iz8|1Z RD Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None
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diff --git a/output/text/626062d1-a045-45e9-9b53-1509ac1c4e8b.txt b/output/text/626062d1-a045-45e9-9b53-1509ac1c4e8b.txt
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index 0000000000000000000000000000000000000000..682cd14c1f61d5441c95bbf8b689e725d2aac71f
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+UUID:603C0BEB-A258-454E-970D-8ACABA1EE96D TCGA-AD-A5EK-01A-PR Redacted SURGCALPATHOLOGYREPOR DIAGNOSIS DIAGNOSIS: Colon and srnall intestine, segmental resections: Invasive adenocarcinoma, moderately differentiated tumor site cannot be determined but appears to be right colon or transverse colon or hepatic flexure. tumor size = 2.5 x 2.3 x 1.0 cm macroscopic tumor perforation - not identified  macroscopic intactness of mesorectum - not applicable histologic type - adenocarcinoma. 1cs-0-3 histologic grade - low-grade (moderately differentiated)  intra-tumoral tymphocytic response - none perl-tumoral lymphocytic response - none sdiocuiiimns Nos 81yo/3 mucinous tumor component* -5% J'ah. Site: Colon, Nis C1s.t medullary tumor component - none tumor invades into but not through muscularis propria. all margins uninvolved by carcinoma C18.a CQcr: Cilon, . uscdiy closest margin - 3 cm, colonic; (radial/circumferential distance = 1.5 cm) treatment effect - not known (and none seen) h lymphovascular permeation - not seen peri-neural invasion - not seen tumor deposits - not identified type of polyp - none identified pT2. pN0 (0/11). pMx small intestine negative for tumor INICAL INFORMATION CLINICAL HISTORY: Preoperative Diagnosis: Adenocarcinoma of transverse colon mass Postoperative Diagnosis:  Symptoms/Radiologic Findings: SPECIMENS: Right coion SPECIMEN DATA GROSS DESCRIPTION: The specimen is received in a single formalin filled container labeled with the patient's name,. nd "right colon" and consists of a right hemicoiectomy specimen comprised of terminal ileum (7.5 cm in iength by 2.0 cm in diameter), cecum/rignt colon (23.0 cm in length and ranging from 3.5 up to 5.0 cm in diameter) and vermiform appendix (4.7 cm in length and ranging trom 0.5 to 0.7 cm in diameter). The specimen is received stapled. closed at both ends. The serosa is pink-tan, smooth to shaggy and features adherent yellow-tan mesocolonic fat. The wall averages 0.7 cm in thickness. The distal colonic mucosa is remarkable for a 2.5 x 2.3 x 1.0 cm, tan-brown, fungating mass that approaches to within 3.0 cm of the colonic. margin and to within 20.0 cm of the ileal margin. On sectioning, the mass extends into but does not penetrate the muscularis and approaches to within. 1.0 cm of the inked deep margin. The remainder of the mucosa is pink-tan and glistening with normal folds. No additional iesions are identified. Sections through the appendix reveal a pinpoint lumen with no discrete lesions. On section and palpation, muitiple firm fatty possibie lymph nodes are identified within the associated fat. They range from 0.3 up to 1.4 cm in greatest dimension.. Also received in the same container is a 2.3 cm in length by 2.7 cm in diameter segment of small bowel received stapled closed at one end and opened at the opposite end. The serosa is pink-tan and glistening with adherent vellow-tan mesenteric fat. On palpation, no lymph nodes are identified. Representative sections are submitted in cassette A1-16 labeled : lesignated as follows: 1 ileal margin, en face; 2 colonic margin, en face;. 3-8 entire mass to inked deep margin. perpendicular, 9 vermiform appenaix; ru-11 six whole possible lymph nodes in each cassette; 12 four whole  possible lymph nodes; 13 one whole possible bisected lymph node; 14 en tace opened end from separately submitted bowel segment; 15 en face Stapled end from separately submitted bowel segment; 16 random ful thickness sections from separately submitted bowel segment. Additionaly. a. yellow and green cassette are submitted for genomics research, each labeled. Criteria OigprosisMscrepanc Py rSte H:PAALnes2ecy UJ
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diff --git a/output/text/626ff8af-d9d2-47c3-9035-ccd866d467d2.txt b/output/text/626ff8af-d9d2-47c3-9035-ccd866d467d2.txt
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index 0000000000000000000000000000000000000000..94a85c33f2fdd5e279c5ebc476cf321bbeaa4046
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+UUID:B169A585-27CD-48A6-A8D7-C14D3824A20A TCGA-LL-A5Ym-01A-PR Redacted PAGE 1 Specimen Inguiry PATIENT: ACCT # LOC: AGE/SX: ROOM : REG DR: REt DOB: BED: DIS STATUS: TLOC: SPEC #: COLL : TIME IN FORMALIN: 100:36 hrs. CLINICAL INFORMATION: Pre-op Diagnosis: Left breast cancer Remarks: Specimen(s) : Left breast tissue IcD-o3 Carcmomti! MICROSCOPIC DIAGNOSIS int,tratny ducta1 w Diseuse 8541/3  LEFT BREAST TISSUE: INVASIVE DUCTAL CARCINOMA SEE COMMENT FOR DETAILS frth  Breash, eenhral yortion C50.1 no 4/2/13 COMMENT(S) PROTOCOL FOR EXAMINATION OF SPECIMENS WITH INVASIVE CARCINOMA OF THE BREAST BASED ON AJCC/UICC TNM 7TH EDITION The following classifications should be adjusted based on additional operative and clinical information. PROCEDURE : Not specified. LYMPH NODE SAMPLING: Not identified SPECIMEN LATERALITY: Left HISTOLOGIC TYPE: Invasive ductal carcinoma TUMOR SIZE : 5.5 cm NOTTINGHAM HISTOLOGIC SCORE: Tubular differentiation: Score 3 Nuclear pleomorphism: Score 3 Mitotic rate: Score 3 Overall grade: Grade 3 TUMOR FOCALITY: Multiple foci of invasive carcinoma DUCTAL CARCINOMA IN SITU: Not identified EXTENT OF TUMOR: Skin: Invasive carcinoma directly invades into the dermis and epidermis with satellite nodules Nipple: Paget's disease of nipple Skeletal muscle: Skeletal muscle not identified  MARGINS : Margins uninvolved by invasive carcinoma Distance from closest margin: 1.2 cm inferior skin PATHOLOGIC STAGING: Primary tumor: pT4b Regional lymph nodes: pNX Distance metastasis: Not applicable ** CONTINUED ON NEXT PAGE **
+
+--- Page 2 ---
+PAGE 2 RUN DATE: Specimen Inquiry RUN TIME: RUN USER: (Continued) PATIENT: SPEC #: GROSS DESCRIPTION: Received fresh for Tissue Banking. labeled with the patient's name and designatod "left breast". Received with two inserted needle localization wires is a 586 gram. 21.0 x 14.0 x 4.5 cm fibrofatty breast. The breast is received with an overlying 20.5 x 12.0 cm skin ellipse. The skin is tan/white and mottled with an eccentric. lateral 9.0 x 8.0 cm areola and indurated 1.5 cm nipple. There are focal pigmented papules on the skin surface. The breast has been oriented with a short suture at one pole of the skin ellipse designating medial. a short double suture designating superior and a double long suture designating deep. The deep margin will be inked blue with the superior margin inked black. the inferior margin inked red. medial is inked yellow and lateral green. The skin surface has an indurated 8.0 x 2.5 cm area extending medial from the nipple. There are focal skipped areas on this lesion with the medial most lesion being 1.5 cm at the medial pole. Sectioning of these indurated areas shows tumor associated with the skin. The tumor extends from beneath the nipple medially with the medial most lesion being 1.2 cm from the inferior. skin edge and approximately 2.2 cm from the medial pole of the skin. No additional areas of induration extend close to the skin margin. The breast is serially sectioned from medial to lateral to have a tumor mass extending across the breast for approximately 5.0 cm. The mass extends from the lateral aspect beneath the nipple medially where it goes from being approximately 1.0 cm in thickness to 2.5 cm. The tumor extends and becomes 5.5 x 5.0 x 3.0 cm and comes within 2.5 cm of the nearest deep margin. The tumor is 3.0 cm from inferior. is approximately 4.5 cm from superior. is 3.0 cm from medial and is approximately 6 cm from lateral with the skin lesion coming within 4.5 cm of lateral. The parenchyma is glistening. yellow and fatty with scant white fibrous tissue. The white fibrous tissue makes up less than 10% of the parenchyma. The tumor predominantly involves ths central medial aspect of the breast. Representative sections are sampled as labeled in the following cassettes: 1 nipple trisected 2 en face section of araola where nipple has been removed. 3 sections with darker papules to include section with subcutaneous tumor adjacent to nearest inferior medial margin. 4-5 additional sections of subcutaneous tumor 6 sections extending lateral and medial from the area where the nipple has been removed 7 lateral most extension of tumor to include overlying skin. 8 nearest deep margin 9-11 near full cross sections of largest area of tumor sampled. 12 upper/outer quadrant sampled 13 lower/outer quadrant sampled 14 upper/inner quadrant sampled 15 lower/inner quadrant sampled PHOTO DOCUMENTATION Image Signed (signature on file). k* END OF REPORT ** lw 31
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diff --git a/output/text/6283bccf-3a63-49db-86e1-0086254f02a0.txt b/output/text/6283bccf-3a63-49db-86e1-0086254f02a0.txt
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+FiNAL DIAGNOSIS: Part t: sentinel Lymph node #1, Left axillA, Biopsy --  iSOLATEd TUmOR CELLS iDEnTiFieD in One Of One Lymph nODe (1/1) (Seo comment). Part 2: Sentinel Lymph node #2, Left axillA, Biopsy -- One benign lymph node (0/1). Part 3: Breast, Left, total mastectomy (360.8 gram3)-- A.  invasive LoeuLar carcinoma, cLassical type, nottingham grade iI (tuBule formation 3, NUclear PleomorphisM 2, mitoTic ActiviTy 2: Total. score: 7/9). B.  The invasive tumor measures 2.8 cm in greatest DimensiOn. C.  LOBULAr CArcinoma in SITu (LcIS), CLAssICAl Type, iS AlSO iDenTIfied in The UPpEr OuTEr Quadrant, Lower outer quadrant, And Lower inner Quadrant, with PagetOid extensiOn IntO Ducts. D.  LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED. 2.  RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA; INVASIVE CARCINOMA IS 0.25 CM FROM THE NEAREST POsTERIOR MArgiN. F.  The InVaSive CarciNoMA is LocAted in The Upper oUTEr QuaDrant. G. NIPPLE IS NEGATIVE FOR TUNOR. H. The ReTiCuLAR DermiS Of The SKiN is INvOlVEd by invASivE CArciNOmA By DiReCt eXTensiON. The skin shoWs a capIllary hemAngIOMA. J. ATYPICAL LOBULAR HYPERPLASIA. K. Calcifications are associated with Benign Breast parenchyma. THE NON-neOPLASTiC BREaST ShOW3 FIBrocysTiC ChAnG wITH APOcRiNe mEtApLASia AnD Ductal epithelal hyperplASiA. M. PREVIOUS BIOPSY SITE CHANGES ARE IDENTIFIED. N.  THe invASIve TUmOr CeLLs Are POSITive fOr ESTrOgeN AnD PrOgeSterOne ReCepTOrs ANO EQUIVOCAL FOR HER-2. AS PER PREVIOUS PATHOLOGY REPORT I (ses commant). COMMENT:  Part 1: On the AE1/AE3 immunohistochemical stain, rare subcapsular positive colls are identifed, which could not be idantifoed on H&E stain. Less than 10 scattered positive subcapsular cells are identifiod.d Part 3: HER-2 studies will be repeated with an addendum to follow.. Blocks lrs1, 19s2, 278i, 2r32: Antibody/Antigen Reanlt AB1/AE3 Negative. CASE SYNOPSIS:  SYNOPTIC - PRIMARY INVASIVE CARCINOUA OF BREAST LATERALITY: Left PROCEDURE: Slmple mnastectomy LOCATION: Upper outer quadrant SIZE OF TUMOR: Maximum dimension invasive component:28 mm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: NO TumOR TYpe (InvasIve component): 1cD~o 3 Infiltrating lobular carcinoma carcinoma,lobuar Histologic type: Classical NOTTINGHAM SCORE: Nuclear grade: 2 in Fistahing, NoS Tubule formation: 3 Mitotc activity score: 2 Total Nottingham score: 7 8520|3 Nottingham grade (1, 2, 3): 2 Sik: brgst,Nbs ANGIOLYMPHATIC INVASION Yes DERMAL LYMPHATIC iNVASION: No CALCIFICATION: Yes, benign zones g11hz Cs.9 TUmor TYPe, iN SITU: LCIS SUrgicAl mArgins invOlVEd by invAsive CompOnent: RD No Distance of Invasive tumor to cosest margin: 2.5 mm. PAGET'S DISEASE OF NIPPLE: No Lymph nodes positive: Lymph nODes EXAmineD: 2 METhOD(S) Of LymPh NODE ExAminATiON: H/E stain. Keratin stain SKIN INVOLVEO (ULCERATION): NO  NOn-neOpLASTIC BreAst TIssuE: ALH, FCD T StAgE, PATHOLOgIC: pT2 N STAGE MODIFIER: (sn) N stage, pathologiC: pNO(i+) m stage: Not applicablo ESTROGEN RECEPTORS: positive PROGESTERONE RECEPTORS: positive HER2INEU: 2+ HER2/NEU (FISH): Equivocal UUID:3FFD87C3-1E75-4A8E-AA26-BF7995E42245  Redacted ual/Sy TCGA-BH-A42T-01A-PR
+
+--- Page 2 ---
+Addendum ** BREAST TUMOR IMMUNOHISTOLOGY RESULTS** HER-2/NEU IMMUNOHISTOCHEMISTRY [NEGATIVE:0,1+; EQUIVOCAL: 2+; POSITIVE: 3+] RESULT  SCORE HER-2/NEU Equivocal 2+ NOTE (for 2+ cases): HER2 FISH is being performed and the results will be subsequently reported in an addendum. SPECIAL PROCEDURES: FISH (PCL) Interpretation nuc ish(D17Z1x2~3,ER882x2~6)[40] Interphase FISH analysis is equivocal for HER-2/NEU gene amplification.. RESULTS: Fluorescence in situ hybridization (FiSH) analysis was performed on a fornalin-fixed Block 3A (left breast totat mastectomy) :siny the DNA probe for the HER-2/NEU gene 1 An adequate number of invasive tumor cells were prese.nt and. evaluated by two independent observers. The ratio of HER-2/NEU signals (ERBB2) to chromosome 17 centromere signais (D17Z1) was determined to be 1.93.  A ratio of greater than 2.2 is considered to be amplified with ratios of 1.80 to 2.20 in the. equivocal range; therefore, this speclmen is eaulvocal for HER2/neu gene amplificatlon. The average number of HER-2/NEU signals per cell was 4.25.The average number of signals for the chromosone 17 centromere was 2.20. Concurrent positive and negative control specimens showed the expected results.. This FISH test is performed using a modification of the Vysis FDA approved PathVysion HER-2 DNA Probe Kit (1:2 LSi HER-2/neu I CEP17 probe : T-dennyb-2 buffer).This FiSH test was developed and its performance determined by the.  Pursuant to the requirements of CLiA '88, this laboratory has established and verified the test's accuracy and precision..
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diff --git a/output/text/628504c0-8db4-4d49-837f-3af9fb4e3732.txt b/output/text/628504c0-8db4-4d49-837f-3af9fb4e3732.txt
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+FINAL DIAGNOSIS: Part 1: right ureter, Distal, shave margin, biopsy- UUID:8716FE82-A4DD-4EFF-B1A6-D679A5C75C76 A.  Senign ureter. TcgA-bT-A42c-01a-pR B.  nEgative for neopLASIA. Redacted Part 2: left, ureter, Distal, Shave margin, Biopsy. A.  Benign ureter. B.  negative for neoplaSiA. Part 3: urinary bLADDer, Distal ureters, prostate, biLAteral Seminal VesicLes, And BiLAteral DistAl Vasa DeFerentia, radical cystoprostatectomy - A. iNVasIVe UrOtheLiAL CARcinOmA, hIgh-gRADe (2004 whO/Isup) (SLiDeS 3E, 3F, 3L, 3R, 3S, 3T, 3U, 3V), ASSOCIATED WITH FOCAL HIGH-GRADE PAPILLARY UROTHELIAL CARCINOMA (SLIDES 3H, 3O, 3S). TUMOR MEASURES 3.5 x 1.5 x 0.4 CM, AND iS PRESENT iN THE LEFt LATERAL WALL AND TRIGONE. CARCiNOMA INFIlTRATES INTO THe SUpERFICIal DETRUSOR MUSCLe (INneR hALF). B.  UrOtheLiAL DySPLASIA ThrOUgh CArCINOmA In SItU IS PRESEnt In The RIght UreTErAL OSTIum (SLide 3g), Left ureteral Ostium (slide 3h), And anterior wall I dome (slide 3n). C. NO DEFiNITIVE ANGIOLYMPHATIC INVASION IS IDENTIFIED (SLIDE 3E). D. All examined Surgical resection margins ARe free Of urothelial neoplasia. E TNM PATHOLOGIC STAGE: pT2a N0 MX (SEE SYNOPTiC). F. BACKgROunD BLADDer With GrAnuLOmAtOUs infLAmmATiOn (hiStORy OF bCg thErApy) anD BIOPSY SITE CHANGES.  BEnign PrOstATe WIth mulTIfOCAl nECrOtiZing GranuLOmAs (HISTORy OF BCg ThERApy), G. NODULAR HYPERPLASIA, FOCAL GLANDULAR ATROPHY, AND CHRONIC INFLAMMATION. H. benign BILATeral Seminal VesicLes. PaRt 4: Lymph nODes, Right PeLViC, EXcisiOn  NO evIdence Of mALignancy in SEventeen Lymph nOdes (0/17). B. ONe Lymph nODe wIth few nOn-neCrOtizing GrAnuLOmAS (SLiDe 4B). Part 5: Lymph nOdes, Left pelVIc, excisiOn A. no evidence of neoplasia In six lymph nodes (0/6). B. One Lymph nODe Ith a SmALl nOn-NECROtizing granuLOma (SLiDe 4K). CASE SYNOPSIS: SynOPTIC DATA - PRImARy URinARy BLADDER TUMORS Specimen type: Radical cystoprostatectomy TUMOR SITE: Trigone, Left lateral wall TUMOR SIZE: Greatest dimenslon: 3.5 cm Additional dimensions: 1.5 x 0.4 cm. HistoLOgiC Type: Urothelial (transitional cell) carcinoma ASSOCIATED EPITHELiAL LESIONS: None identified HISTOLOgIC GRADE: Urothelial carcinoma - High-grade TumOr COnfIgUrATiON: Papillary, Flat, Ulcerated PATHOLOgIC STAGInG (pTNM): pT2a pN0 Number of nodes examined: 23 Number of nodes involved: 0 pMX MARGINS:  Margins uninvolved by invasive carcinoma. Margin(s) uninvolved by carcinoma in situ VENOUS/LYMPHATIC (LARGE/SMALL) VESSEL INVASION (V/L): Absent DIReCT EXTeNSiOn OF InVASIve TumOR: None identified ADDItiONAl PATHOLOgIC FINDINgS: Urothelial carcinoma in situ Therapy-related changes 1cd-o-3 urotnli a, carcinomg,p pinar 8l303 Sjt* paih : badder N0s Cu7.9 CQcF: bladde1;wq1, pHcm1 q-112 RD
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+Icd-0-3 Carcinoma,nf1t^atwg duct, N0s 85Oyf3 Site Cod: bruast, Nos C50,9 12|3410 hw Final Diagnosis Breast, right, wide local excision: Infiltrating ductal carcinoma, Nottingham grade IlI (of III), forming a mass, 1.2 x 1.1 x 0.9 cm. (AJCC pT1c). Angiolymphatic invasion is not identified. The surgical margins are negative for tumor. The closest margin (inferior) is free by 0.3 cm. Lymph nodes, right axillary sentinel, excision: Multiple (2) right axillary sentinel lymph nodes are negative for tumor. Blue dye is not identified in either of the right axillary sentinel lymph nodes. Immunohistochemical cytokeratin stain was performed on the paraffin embedded sentinel lymph node tissue and confirms the H&E impression [AJCCpTN(i-)]. Lymph nodes, right axillary, excision: Multiple (6) right axillary lymph nodes are negative for tumor. HER2/neu protein overexpression is negative, score of 0, according to the interpretation guidelines in the FDA-approved HercepTest. UUID:0DEAC35F-8B73-4A9F-B7FA-2F501B736B0E TCGA-AR-A1A-01A-PR Redacted
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diff --git a/output/text/62c32125-507f-4672-b9e3-c13d7608a0f2.txt b/output/text/62c32125-507f-4672-b9e3-c13d7608a0f2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5cceae0adf8f99c8b9aaac38cf54399aa8843493
--- /dev/null
+++ b/output/text/62c32125-507f-4672-b9e3-c13d7608a0f2.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+8500f3 Site Code : briast. Nos C50.9 PAtIeNt hIstory: CHIEF COMPLAINT/ PRE-OP/ POST-OP DIAGNOSIS: Left breast cancer 1.3 cm. positive nodes. Right invasive ductal carcinoma.9 a'clock. LMP DATE: Not provided. PROCEDURE: Bilateral segmental mastectomies, right sentinel lymph node biopsy. left axillary lymph node dlssection. SPECIFIC CLINICAL QUESTION: Not provided. OUTSIDE TISSUE DIAGNOSIS: No. PRIOR MALIGNANCY: No. UUID:DF536409-601F-4893-9F8A-A283728F9999 CHEMORADIATION THERAPY: No. TCGA-BH-A18H-01A-PR. Redacted Other Diseases: No. FINAL DIAGNOSIS: Part 1: breast,rightat 9 O'clock, segmental mastectomy -- A. Invasive Ductal Carcinoma, nO SpeciaL type (See comment). B.  nOTtingham GraDe 2 (tuBuLe fOrmATiOn: 3, nUClEaR PLeOmOrphiSm: 2, mITOtic ActMity: 1; TOTAL SCORE: 6/9). C. The InvasIve tumOr Measures 0.8 Cm In LARgest DimensIOn. D.  DUCTAL CARCINOMA IN SITU (DCIS), nUCLEAR GRADE 2, CRiBRIFORM, MiCROPAPILLARY AND FOCAL  PAPILLARY TYPE WITH CALCIFICATiONS. E. Lobular involvement by ocis is present. F. THE DCIS CONSTITUTES 60% OF THE TOTAL TUMOR VOLUME AND iS PRESENT ADMIXED AND ADJacent to The inVasive component. G. NO LYMF OVASCULAR SPACE INVASION IS NOTED. H. RESEC ION MARGINS ARE NEGATIVE FOR TUMOR.  BOth inVasive CArcinOma And In SItU CARcinOmA ARe mOre ThAn 0.5 Cm From ALL mArginS. FOCAL ATYPICAL DUCTAL hYPERPLASIA K. PReVIOUS BIOPSY SITE CHAnGES. The non-nEOpLAStic BreaSt ShoWs FiBrOcystic ChAngeS. M. the invasive tumOr CeLLs are pOsitive fOr estrOgen (H-score 230), pOsitive fOr PROGESTERONE RECEPTORS (H-score 180), AND nEGATIVE FOR HER-2/NEU (IHC 2+, FISH not amptified) AS PER THE PREVIOUS PATHOLOGY REPORT ( Part 2: Right AxILLAry SEntinel Lymph NOde #1, BiOpSy - One Lymph node, negative for metastatic tumor (0/1). Part 3: breast, Left.at 12 O'clock, segmental mastectomy -- A.  Inva$iye qugtal carcinoma, no Special type. NOTTInghAm grade 3 (tuBuLe fOrmAtiON: 3, nUcleAr PleOmorphiSm: 3, mItOtIc ActIVity: 2; TOtal SCOre: 8/9). C. THe InVasIve tUmOR meaSURes 1.3 Cm In LARGESt DimensiON. D.  ADDITIONAL SATELLITE NODULE OF InVASIVE CARCINOMA MEASURING 0.2 Cm IS IDENTIFIED. E. The Satellite nodule is 0.5 Cm from the dOminant tumor nonii F F. DUCTAL CARCInOMA iN SITU (DCIS), NUCLEAR GRADE 3, SOLID tYPE. G. LOBULAR INVOLVEMENT BY DCIS IS PRESENT. H. THE DCIS CONSTITUTES 15% OF THe TOTAL TUmOR VOLUmE AND iS PRESENT ADJACENT tO THE INVASIVE COMPONENT.  FOCAL LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.S J. RESectIOn mArgiNs Are nEgaTIvE fOR CARcinomA. K. iNVASIVE CARCINOMA IS 0.4 CM FROM THE NEAREST (POSTERIOR) MARGIN. DUCTAL CARCINOMA IN SITU IS MORE THAN O.5 CM FROM ALL MARGINS. M. SKIN IS NEGATIVE fOR TUMOR. N.  PREVIOUS BIOPSY SITE CHAnGES. O. THE NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES p. THE INVASIVE TUMOR CELLS ARE POSITIVE FOR ESTROGEN RECEPTOR (H-sCOre 300), POSITIVE FOR PROGESTERONE RECEPTOR (H-score 235), AND NEGATIVE FOR HER-2/NEU, AS PER PREVIOUS PATHOLOGY REPORT PArt 4: LEft AxIlLARy CONTenTS, EXCiSIOn --  METASTATIC CARCINOMA INVOLVES TWO OF TWENTY-FOUR LYmPH NODES (2/24). B. THE LARGEST METASTATIC FOCUS MEASURES 4.O CM. C.  NO EXTRACAPSULAR EXTENSION IDENTIFIED. COMMENT: Part 1: The gross examination demonstrated an ill-dofinod firm nodule with surrounding fibrous tissue measuring 2.0 x 1.1 x 0.7 cm. This area was entirely submitted for histologic evaluatlon and shows Invasive carcinoma in only two sections of 0.4 cm thickness and therefore, the invasive tumor size is estimated to be 0.8 cm in largest dimension. The  majority of this gross lesion is composed of ductal carcinoma in situ (DciS). Part 3: The invasive tumor demonstrates scattered cells with intra-cytoplasmic lumina or signet ring cell morphology-
+
+--- Page 2 ---
+CASE SYNOPSIS:  SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST LATERALITY: Right PROCEDURE: Segmenta! LOcATIOn: Clook position:9.00 Size of tumor:  Maximum dimension invasive component: 8 mm  MULTICENTRICITY/MULTIFOCALITY OF INVASIVE fOCI: No TUMOR TYPE (invasive component): Ductal adenocarcinoma, NOS NOTTingham SCOre: Nuclear grade: 2 Tubule formation: 3 Mitotic activity score: 1 Total Nottingham score: 6 Nottingham grade (1, 2, 3): 2 ANGIOLyMPhATIC iNVASiON: No DERMAl LymphATIC INVASION: Not applicable CALCIFICATION: Yes, benign zones Cribriform TUMOR TYPE, IN SITU:  Micropapillary SURGICAL MARGINS InVOLVED BY InVASIVE COmPONEnT:E No Distance of invasive tumor to closest margin: 6 mm Surg margins involved By in SitU component: No Distance of in situ disease to closest margin: 6 mm LYMPH NODES POSITIVE: 0 Lymph noDes Examined: 1 metHOD(S) Of Lymph nODE ExAmInATIOn: H/E stain SENTINEL NODE METASTASIS: No non-neopLAstic breast Tissue: ADh, fCD t stage, pathologic: pT1b N STAGE MODIFIER: (sn) N stage, pathologic: pNO Not applicable m stage: ESTROGEN RECEPTORS: positive, H-score: 230 PROGESTERONE RECEPTORS: positive, H-score: 180 HER2/NEU: 2+ HER2/NEU (FISH): Not amplified  SynOpTiC - PRImARy InVasiVE CArCiNOMA OF BREAStE LAteRaLiTy: ( Left PROCEDURE:  Segmental LOcaTIOn: Clock position:12.00 Size Of Tumor:  Maximum dimension invasive component: 13 mm MULIICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: Yes Tumor aggregate Size: Sum of the sizes of muttiple invasive tumors: 15 mm TUMOR TYPE (invasive component): Ductal adenocarcinoma, NOS NOTTINGHAM SCORE: Nuclear grade: 3 Tubule formation: 3 Mitotic activity score: 2 Total Nottingham score: 8 Nottingham grade (1, 2, 3): 3 ANGIOLYMPHATIC INVASION: Yes DERMAL LYMPHATIC INVASION: No CALCIFICATION: No Tumor type, in situ: Solid SUrgICAl mArGins inVolVeD By invaSIvE Component:E No Distance of invasive tunor to dosest margin: 4 mm SURG MARGINS INVOLVED BY IN SITU COMPONENT: Lymph nODEs POsITIVE: No 2 LyMPH NODES EXAMINED:E 24 MEtHOD(S) Of Lymph nODE EXAMInATiOn: H/E stain SiZe Of noDal metastases: Diameter of largest lymph node metastasis: 40 mm Lymph nOde metAStasis(-es) with extracapsuLAr ExtensiOn: No SKIN INVOLVED (ULCERATION):  No NON-NEOPLASTiC BREAST TISSUE: FCO t stage, pathologic: pT1c N stage, pathologic: pN1a M STAGE: Not appllcable ESTROGEn RECEPTORS: positive. H-score: 300  Progesterone receptors: positive, H-score: 235 HER2/NEU: 1+
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diff --git a/output/text/62d99c9f-3d98-42cf-9269-1b3fed65bda0.txt b/output/text/62d99c9f-3d98-42cf-9269-1b3fed65bda0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b7c9f6949dc39c9a0a187a6bc69c685352383fde
--- /dev/null
+++ b/output/text/62d99c9f-3d98-42cf-9269-1b3fed65bda0.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TCGA-AN-A041-01A-PR Redacted TSS Patient ID:. Case #: : DOB: Sex: Female Ethnicity (Race): Cancer Sample Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma Date of Procurement. Anatomic Site: Breast Tumor location: Primary Tissue Specification: Tumor Specimen Matrix: Tissue Specimen Format: Frozen Container: cryomold Type of Procurement: Radical mastectomy Grade: 2 T Stage: 2 N Stage: 1a M Stage: 0 Treatment: none Treatment Details: n/a.  Normal Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw Matrix: Blood Specimen Format: frozen Container: tube Date of Procurement:. 1cs-0-3 cavenemu uifi!fnfhj eluct,nvs 85ovf3 Situ: buist, nus c50.9
\ No newline at end of file
diff --git a/output/text/62e4e474-7ab5-4c19-8818-05cfc85cbd0f.txt b/output/text/62e4e474-7ab5-4c19-8818-05cfc85cbd0f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7677e215b22774afa030c1cecf1cc076935fd4fd
--- /dev/null
+++ b/output/text/62e4e474-7ab5-4c19-8818-05cfc85cbd0f.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TD O 3 Carcnones joapillay neralcasl UUID:9A0E64A4-CC87-4957-9333-19E12493FA9C 8260|3 CGA-5P-A9KA- 01A-PR Redacted S:t!R Y idruy N6S Co4.9 Y34|13|4 Focal Papillary Renal Cell Carcinoma, Type I. Stage: pT1b, pNX, pMX, V0, L0, R1 Grade: GII ICD-0-Code: 8260/3 Loterahy= Riyu+  h 5/6/4
\ No newline at end of file
diff --git a/output/text/62efe260-be80-4f13-90e2-78681648f488.txt b/output/text/62efe260-be80-4f13-90e2-78681648f488.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c59385431272e6fc1fdfe864461da087d59c4c34
--- /dev/null
+++ b/output/text/62efe260-be80-4f13-90e2-78681648f488.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UUID:66492A0C-48DA-4C18-A4A8-9052820CE508 TCGA-FD-A3SS-01A-PR Redacted Case#: Sample   Gender: Male DOB: Race: Report Date: Pathology Report: jcD-o-3 cafcinom9,wr0+he1iq1,nOs 8120J3 Surgical Pathology Reporte Sik: Pa$h: blgdder,nos C67.9 FINAL PATHOLOGIC DIAGNOSIS Cacf: bladdler,trigone C67.0 A. Left pelvic lymph nodes; dissection:. - Eight of twelve lymph nodes, positive for metastatic urothelial carcinoma 49-12 (8/12). Ro - Extranodal tumor extension present. B. Right pelvic lymph nodes; dissection:  - Two of two lymph nodes, positive for metastatic urothelial carcinoma (2/2). - Largest lymph nodal tumor measures 3.5 cm, with extranodal extension. C. Right pelvic lymph nodes; dissection:. - Ten of eleven lymph nodes, positive for metastatic urothelial carcinoma (10/11). - Extranodal tumor extension present. D. Urinary bladder and prostate; cystoprostatectomy: - Invasive high grade urothelial carcinoma, with mixed conventional, micropapillary features and squamous differentiation, see pathologic parameters. - Tumor diffusely infiltrates the bladder wall, involving all bladder subsites, invades thru the muscularis propria, extends into the perivesical fat, involves bilateral seminal vesicles, and prostatic stroma. - Tumor involves the margin at posterior perivesical soft tissue adjacent to prostate. - Distal urethral margin, free of tumor. E. Pre-sacral lymph nodes; dissection: - One of two lymph nodes, positive for metastatic urothelial carcinoma (1/2). - Extranodal tumor extension present. F. Right common iliac lymph nodes; dissection:
+
+--- Page 2 ---
+- One of one lymph node, positive for metastatic urothelial carcinoma (1/1). G. Left distal ureter; excision: - Porion of ureter, no tumor. H. Right distal ureter, excision:. - Portion of ureter with multiple microscopic tumor foci present within. lymphovascular spaces in ureteral wall and periureteral fat. Urothelial Carcinoma Pathologic Parameters 1. Tumor type: Invasive high grade urothelial carcinoma, with mixed conventional, micropapillary features and squamous differentiation. 2. Grade of tumor: High grade.. 3. Depth of invasion: Extravesicular soft tissue and adjacent organs (prostatic stroma and bilateral seminal vesicles).. 4. Tumor distribution: Diffuse, involving dome, right lateral wall, left. Iateral wall, trigone, anterior wall and posterior wall, with extravesical extension. 5. Ureteral margins: Tumor present in multiple lymphovascular spaces at the. margin. 6. Distal urethral margin: Negative for tumor. 7. Soft tissue margin or serosa: Positive for tumor, at posterior perivesical soft tissue adjacent to prostate (slides D7 and D10). 8. Lymph nodes: Positive for tumor (22/28), largest lymph nodal metastasis 3.5 cm, with extranodal extension. 9. pTNM: pT4,N3,MX, R1. Effective this Checklist utilizes the. ... edition TNM staging system for Bladder of the American Joint Committee on Cancer (AJCC) and the International Union Against Cancer (UICC). xx {} mD Interpretation performed by the Attending Pathologist and reviewed with the. Resident/Fellow, {], M.D., Ph.D. Electronically Signed Out by [], MD Clinical History:. This is a  year-old male with bladder cancer undergoing cystectomy. Specimens Received: A: Left pelvic lymph nodes. B: Right pelvic lymph nodes
+
+--- Page 3 ---
+C: Right pelvic lymph nodes D: Bladder/ prostate E: Pre-sacral Iymph nodes F: Right common iliac lymph nodes G: Left distal ureter H: Right distal ureter Gross Description: The specimens are received in eight containers each labeled with the patient's name and medical record number. A. The first container is additionally identified as, "ieft pelvic lymph nodes". Received fresh and placed in formalin is a 5.5x5.5x1.5cm yellow lobulated fatty tissue. Multiple lymph nodes are identified, ranging in size from 0.3 cm to 5 cm. They are submitted as follows: A1: 5 nodes A2-3: 3 nodes in each cassette A4-6: 1 node, bisected in each cassette A7-9: 1 node, serially sectioned. B. The second container is additionally identified as, "right pelvic lymph nodes". Received fresh and placed in formalin is a 3.5 x 2.5x 2.5 cm yellow lobulated fatty tissue. 2 lymph nodes are identified, measuring 3.5x 2.5x 1.5 cm and 3.5x 1.0x 1.0 cm in size. The nodes are submitted as follows: B1-7: bigger node, B8-9: small node C. The third container is additionally identified as, "right pelvic lymph nodes". Received fresh and placed in formalin is a 5.5x5.5x1.9 cm yellow  lobulated fatty tissue. Multiple lymph nodes are identified, ranging in size from 0.3cm -6.6cm. They are submitted as follows: C1-4: 2 nodes in each cassette C5-6: 1 node, bisected C7: 1 node, bisected C8-9: 1 node, serially sectioned. C10-11: 1 node, serially sectioned D. The fourth container is additionally identified as, "bladder/prostate". Received fresh and placed in formalin is a 433.1 gram, 12.5 x 9.5 x 6.5 cm cystoprostatectomy specimen with attached mesenteric fat. The bladder measures 7.5 x 7 x 6 cm. The right ureteral stump measures 2.1 cm and the left 2.0 cm, and both probe patent with resistance. The prostate measures 5.1 x 4.2 x 3.8 cm. The seminal vesicles and vas deferens are severely adhesed to the dome of the bladder. The right seminal vesicle estimates 3.0 x 2.0 x 1.5 cm and the length of right vas deferens cannot be determined due to severe adhesions. The left seminal vesicle estimates 4.5 x 2 x 1.4 cm and the left vas deferens 11.5 cm long by 0.2-0.4 cm in diameter. The right half of the prostate and bladder is
+
+--- Page 4 ---
+inked blue and the left half is inked black. The prostate is opened anteriorly along the urethra and continued superiorly and laterally through the bladder. The prostate is serially sectioned from apex to base to reveal unremarkable, yellow parenchyma. The bladder is diffusely involved by polypoid (0.1-0.5 cm) lesions, covering 9.0  by 6.5 cm surface area. Serial sectioning reveals tumor invasion into the adipose tissue to a depth of 2.5 5 cm, abutting the inked margin. Right seminal vesicle is involved by tumor. No normal mucosa is present. Gross photographs are taken. Representative sections are submitted as follows: D1: Left ureter margin D2: Right ureter margin D3: Urethral margin D4: Prostate apex D5-8: Representative prostate through verumontanum D9-12: Representative prostate above verumontanum D13-14: Right and left Seminal vesicles and vasa deferentia D15-17: Multiple surface polypoid lesions D18-29: Deepest invasion (D18-20: One full thickness section involving seminal vesicle, D21: Tumor involving serosa, D22 and D23: Tumor involving fat, D24-27: One full-thickness section tumor involving fat, D28-29: One full-thickness section tumor involving fat) E. The fifth container is additionally identified as, "pre-sacral lymph nodes". Received fresh and placed in formalin are 4 pieces of nodular tissue. 3 of them are submitted in E1, the fourth one is bisected and submitted in E2. Remaining specimen is entirely submitted in E3. F. The sixth container is additionally identified as, "right common ileac". Received fresh and placed in formalin are two nodules, measuring 2cm and 1 cm respectively. The nodes are bisected and submitted in F1 and F2. G. The seventh container is additionally identified as, "left distal ureter, stitch on nonmargin side". Received fresh and placed in formalin is a 0.4cm in length by 1.0 cm internal circumference segment of ureter, which is received opened longitudinally. A stitch is present at one side of the specimen, designating the non-margin side. The margin side is inked blue. The specimen is sectioned longitudinally and entirely submitted in G1. H. The eighth container is additionally identified as, "right distal ureter, stitch on margin side". Received fresh and placed in formalin is a 0.9 cm long by 0.6 cm in diameter segment of ureter, with a stitch designating the marginal side. This side is inked blue. The specimen is opened longitudinally and no
+
+--- Page 5 ---
+gross lesions are identified. The ureter is entirely submitted as H1 XX [], M.D., Ph.D.
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diff --git a/output/text/62fbeda9-335d-480d-aeb6-df220d5f7719.txt b/output/text/62fbeda9-335d-480d-aeb6-df220d5f7719.txt
new file mode 100644
index 0000000000000000000000000000000000000000..97a315432825b3e987e4d223104a88352d0269d9
--- /dev/null
+++ b/output/text/62fbeda9-335d-480d-aeb6-df220d5f7719.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SPECIMEN DESIGNATEDRIGHT COLONPARTIAL COLECTOMY(27 Cm ADENocARcINOMA, with focal mucinous features,low grade, moderately differentiated (4.5 cm in greatest dimension) Tumor is located in right colon, forms a polypoid mass,is ulcerative,is diffusely infiltrative, and has an infiltrating border. Tumor invades through muscularis propria into serosa. Proximal and distal resection margins are negative for tumor. Invasive tumor is 7 cm from proximal resection margin, 13 cm from distal resection margin, and 0.2 cm from radial resection margin. Lymphovascular invasion is not identified. Extramural venous invasion is not identified. Perineural invasion is not identified. Peritumoral lymphoid response (including Crohn's-like infiltrate) is mild. Residual adenoma is absent. Regional lymph nodes (positive: total): 0:22. AJCC Classification (6th edition: pT3a N0 MX. CLINICAL DATA: History: Not provided Operation: Lap-assisted right colectomy Operative Findings: Not provided Clinical Diagnosis: Colon ca TISSUE SUBMITTED: A/1.Right colon GROSS DESCRIPTION: The specimen is received fresh, labeled with the patient's name, unit number, and "#1. Right colon", and consists of a right colectomy specimen including terminal ileum (7.6 cm in length x 2.0 cm in diameter with a stapled proximal resection margin (11.0 cm) and ascending colon (20.0 cm in length x 3.5 cm in diameter) with a distal stapled resection margin (4.l cmNo appendix is identified. The proximal resection margin is inked blue and the distal resection margin is inked black.A tan/black tattoo (6.2 cm x 4.0 cm) is approximately 6.0 cm distal from the ileocecal valve. A tan/pink polypoid, centrally ulcerating mass (4.5 x 4.0 x 3.0 cm) is present 7.0 cm from the proximal resection margin,13.0 cm from the distal resection margin, and 1.5 cm distal from the ileocecal valve. The serosa underlying the mass is puckered and is inked orange. The mass abuts the radial margin. The area surrounding
+
+--- Page 2 ---
+the tumor (11.0 x 5.0 cm) is tan/white and slightly firmer in consistency than the uninvolved mucosa. The pericolonic adipose tissue contains multiple lymph node candidates ranging up to 1.2 cm in greatest dimension.All lymph node candidates are submitted. The specimen is photographed prior to fixation. Representative sections of the tumor and normal mucosa are submitted for tissue banking. Al: Proximal stapled resection margin, perpendicular section, 1 frag, Micro A2: Distal stapled resection margin, perpend r section,1 frag, Micro A3-A4:Deepest extent of mass,1 frag each, Micro A5: Mass in relation to normal mucosa,1 frag, Micro A6:Representative section of pale mucosa, 1 frag, frags, Micro A8-All: Lymph node candidates,multi frags, By his/her signature below, the senior physician certifies that he/she personally conducted a microscopic examination ("gross only" exam if so stated) of the described specimen(s) and rendered or confirmed the diagnosis(es) related thereto.
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diff --git a/output/text/62ffa180-1854-4090-8da1-58fc75bb719b.txt b/output/text/62ffa180-1854-4090-8da1-58fc75bb719b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9923c0fe821712f06794c4b2ac27c85200954d14
--- /dev/null
+++ b/output/text/62ffa180-1854-4090-8da1-58fc75bb719b.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TCGA-CW-5591 Surgical Pathology REVISED REpORT (Addendum/Procedure included) TISSUE DESCRIPTION:S Right kidney (16 x 15 x 6 cm) with 7 cm of left ureter, biopsy from. right kidney. (3 x 2 x 0.8 cm), tissue from right lower lobe lung retrocaval lymph nodes and intra-aortic caval tissue (2.3 x 1.5 x 0.9 cm) DIAGNOSIS: Kidney, right, biopsy: Grade 2 (of 4) renal cell carcinoma, clear cell type.  Coagulative necrosis present. Kidney, right, radical nephrectomy: Grade 2 (of 4) renal cell carcinoma, clear cell type, forms a 14.0 x 10.0 x 6.0 cm mass located in the right kidney. The tumor extends into the perinephric. fat. The renal vein is grossly free of tumor. The tumor does not involve the collecting system. present.  Sarcomatoid differentiation is absent.  The surgical margins are negative. No renal hilar lymph nodes are identified. The adrenal gland is absent. Lung, right lower lobe, wedge excision No.1: Metastatic grade 2 (of 4) renal cell carcinoma forming a 1.0 cm nodule. Surgical margins. are free of involvement. Lung, right lower lobe, wedge excision No.2: Metastatic grade 2 (of 4) renal cell carcinoma forming a 0.8 cm nodule. Lymph nodes, retrocaval, excision: Multiple (2) retrocaval lymph nodes are negative for tumor. Soft tissue, intra-aortic caval region, excision: Benign fibroadipose and nerve tissue. ADDENDUM: Immunohistochemical stain for EGFr shows 100% of tumor cells positive, with 2+ intensity.  This tumor can be considered an EGFR-expressing carcinoma. Response to treatment does not appear to correlate with intensity of staining or number of cells positive.
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diff --git a/output/text/6324aacf-6266-4a4f-b508-27beb1ce5c6b.txt b/output/text/6324aacf-6266-4a4f-b508-27beb1ce5c6b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a12b120876afc3739395aee66f06f1f10a1c43ab
--- /dev/null
+++ b/output/text/6324aacf-6266-4a4f-b508-27beb1ce5c6b.txt
@@ -0,0 +1,30 @@
+
+--- Page 1 ---
+UUID: 58054D1A-3A8D-40DD-A643-846CAF242494 TCGA-MS-A51U-01A-PR Redacted SPECIMEN(S): 1cs-0-3 A: Left sentinel lymph node #1 earciom+, nfji1trsHny 1vbulw,nos 852y3 B: Left sentinel lymph node #2 Sife: bruust, Nos sc50.9 C: Left breast with axillary lymph nodes 10/4] D: Right breast FINAL DIAGNOSIS: **Amended Microscopic Breast Carcinoma Checklist (see below)** A. Lymph nodes, "left sentinel lymph node #1," biopsy (including AFS1) - Metastatic carcinoma in one lymph node consistent with breast primary (1/1) - Metastatic deposit measures 6mm in greatest dimension. - No extracapsular extension B. Lymph nodes, "left sentinel lymph node #2," biopsy (including BFS1) - Two lymph nodes with no evidence of malignancy (0/2) C. Breast left, modified radical mastectomy. - Invasive lobular carcinoma - Multifocal with largest tumor 3.2 cm in greatest dimension in upper outer quadrant; additional foci in retroareolar area and lower
+
+--- Page 2 ---
+outer quadrant up to 1.1cm in greatest dimension - Histological grade = 2/3 (score: tubules 3 + nucleus 2 + mitoses 1 = 6/9) by criteria - Mitotic index = <1/hpf (low) - Margins negative for invasive carcinoma (nearest = 1.2 cm; location: deep margin) - Lobular carcinoma in situ (LCIS) - LCIS comprises 5% of total carcinoma in specimen - Nuclear grade 1/3 by SBR criteria (low). - Margins negative for LCIS - Metastatic carcinoma present in one of fifteen lymph nodes (1/15) - Tumor deposit measures 4mm in greatest dimension, with no extracapsular extension - Nevus cell aggregate also identified. D. Breast, right, prophylactic simple mastectomy - Fibrocystic changes - Columnar cell hyperplasia - Usual ductal hyperplasia - No evidence of atypical hyperplasia, in situ carcinoma, or invasive carcinoma - Skin, nipple, and resection margins unremarkable COMmENT: This report was amended to correct the number of positive nodes in the
+
+--- Page 3 ---
+microscopic section, in the "Breast Carcinoma Checklist." The Diagnosis above is unchanged, and is correct, with a total of 2 positive nodes; that count has been re-verified by review of the microscopic slides. The microscopic checklist section has now been corrected, to indicate that a total of 2 nodes are positive. The "N" stage has thus been corrected to pN1, as well. This case was discussed with at a recent conference, and he in fact pointed out this discrepancy. I informed him at that time that I would make these corrections to the report. CLINICAL HISTORY: The patient is a  year-old woman with biopsy proven infiltrating Iobular cancer of the left breast (ER+ PR+ Her2/neu-). Operative procedure: Sentinel lymph node biopsies, left modified radical mastectomy and right simple mastectomy. GROSS: Received are four fresh containers each labeled with the patient's name A. The first container is additionally labeled "A - left sentinel lymph node #1." The specimen consists of a 2.1 x 2.06 cm fragment of pale, yellow-tan, fibrofatty tissue. A single potential Iymph node is identified measuring 1.8 cm in greatest dimension. The node is serially sectioned and entirely submitted for frozen section analysis as AFS1.
+
+--- Page 4 ---
+B. The next container is labeled "B - left sentinel lymph node #2." The specimen consists of a 1.8 x 1.5 x 0.4 cm fragment of yellow-tan, fibrofatty tissue. Two potential lymph nodes are identified measuring 0.8 x 0.4 cm in greatest dimension. The smaller node is inked black. The nodes are serially sectioned and entirely submitted for frozen section analysis as BFs1. The remaining adipose tissue is submitted for permanent sections in cassette B2. Summary of Sections: BFS1 - two potential sentinel lymph nodes, entirely submitted. B2 - remaining soft tissue.. C. The next container is labeled "C - left breast at 12 o'clock with left axillary node dissection." The specimen consists of a 613 gm modified radical mastectomy with axillary tail. The breast measures 17 cm medial to lateral, 15.5 cm superior to inferior and 3.9 cm superficial to deep. The attached axillary tail measures 8 x 7.5 x 2 cm. There is an attached ovoid portion of skin measuring 4 x 3.5 cm with an everted, freely mobile nipple which measures 2.5 x 2.5 cm with the areolar complex. The deep fascial plane is inked black, the  remaining superior half is inked blue with the remaining inferior half inked green. The specimen is serially sectioned from medial to lateral. A gray-white, firm, irregularly-bordered mass is identified in the upper outer quadrant measuring 3.2 x 2.2 x 1.3 cm in greatest dimension.
+
+--- Page 5 ---
+This mass is consistent with a bilobed single mass. However, it could represent two separate masses. The central area of the mass is submitted which could represent normal parenchyma in between the two masses. The mass is 1.8 cm to the deep margin and 2.5 cm to the nipple. A dumbbell-shaped biopsy clip is identified near the medial portion of the mass. There are firm, indurated possibly calcified areas located posteriorly to the nipple. The axillary tail is dissected to reveal 19 potential lymph nodes ranging in size from 0.3 to 2.6 cm in greatest dimension. The nodes are entirely submitted. The specimen is sectioned and laced in formalin. Summary of Sections: C1 - middle portion of mass. c2-C3 - medical portion of tumor. C4 - lateral portion of tumor with deep margin. C5 - lateral portion of tumor. C6 - representative upper inner quadrant. C7 - representative upper outer quadrant. C8 - representative lower outer quadrant. c9 - representative lower inner quadrant. C10 - representative retroareolar areas of induration. C11 - nipple. c12 - one potential lymph node, bisected, entirely submitted. c13 - one potential lymph node, bisected, entirely submitted. C14 - one potential lymph node, bisected, entirely submitted.
+
+--- Page 6 ---
+C15 - six potential lymph nodes, submitted intact. C16 - six potential lymph nodes, submitted intact. C17 - four potential lymph nodes, submitted intact. D. The next container is additionally labeled "D - right breast." The specimen consists of a 510 gm simple mastectomy measuring 20 x 17 x 2.8 cm. Attached roughly ovoid portion of skin measures 3.9 x 2.5 cm which is pale tan without lesions identified. The attached nippie is everted and freely mobile and measures 2.7 x 2.0 cm with the areolar complex. The deep fascial plane is inked black. The remaining specimen is inked blue. The specimen is unoriented. It is serially sectioned to reveal yellow-tan, lobulated parenchyma with interspersed, dense and gray-white fibrosis and fibrocystic change. A small 0.6 cm area of hemorrhage is identified located at the periphery. Masses or lesions suspicious for malignant process are not grossly identified. The specimen is arbitrarily divided into quadrants and representative sections are submitted. The specimen is sectioned and placed in formalin . Summary of Sections: D1 - nipple. D2-D3 - representative of quadrant 1. D4-D5 - representative of quadrant 2. D6-D7 - representative of quadrant 3. D8-D9 - representative of quadrant 4.
+
+--- Page 7 ---
+INTRAOPERATIVE CONSULTATION: FROZEN SECTION DIAGNOSIS: AFS1: Left sentine! lymph node #1 - "Metastatic breast carcinoma in one lymph node.". FROZEN SECTION DIAGNOSIS: BFS1: Left sentinel lymph node #2 - "Two lymph nodes with no evidence. of malignancy.'. MICROSCOPIC:E Microscopic examination is performed. Permanent sections confirm the frozen section diagnoses. Breast carcinoma checklist: Operative procedure: mastectomy Specimen size: 17 x 15.5 x 3.9 cm Specimen integrity: Intact Tumor location: Upper outer quadrant, lower outer quadrant, and. sub-areolar
+
+--- Page 8 ---
+Tumor focality: Multifocal Tumor size: 3.2 x 2.2 x 1.3 cm, with other nodules as large as 1.1 cm Tumor extent: tumor limited to breast, without invasion of skin or muscle Tumor type: Infiltrating lobular carcinoma Histologic grade: 2/3 (score: tubules 3 + nucleus 2 + mitoses 1 = 6/9) by ESBR criteria. Mitotic index: <1/hpf (low) Lymphovascular invasion: Present Perineural invasion: Absent Margins of invasive carcinoma: Negative (nearest = 12 mm; location; deep) In situ carcinoma: Present; Lobular carcinoma in situ (Lcis) Extent of in situ carcinoma: Non-extensive, comprises 5% of total carcinoma
+
+--- Page 9 ---
+Grade of in situ carcinoma: 1/3 by SBR criteria (low). Margins of in situ carcinoma: Negative Paget's disease: Absent. Number of Lymph nodes examined: 18 Number of Lymph nodes positive: **2** (1/3 sentinel nodes, and 1/15 nodes from mastectomy) Size of largest metastatic focus: 6 mm Extracapsular extension: Absent. Receptor studies (performed on prior biopsy). ER+ PR:+ her2/neu:- AJCC Cancer Staging:e pT: Primary tumor (pT) pT2
+
+--- Page 10 ---
+pN: Regional nodes (pN) **p1** **(2 total positive nodes)** M: Distant metastases (M) MO (clinically absent).
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diff --git a/output/text/6339bb40-5446-4ae3-9f06-567d056f3cac.txt b/output/text/6339bb40-5446-4ae3-9f06-567d056f3cac.txt
new file mode 100644
index 0000000000000000000000000000000000000000..725dcd12c3fc400fd3dfacf0f542c55a514f62f2
--- /dev/null
+++ b/output/text/6339bb40-5446-4ae3-9f06-567d056f3cac.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:BE077658-3286-455B-A84E-87CEA81BEF59 TCGA-FB-AAPY-01A-PR Redacted TSS Patient ID: Surgical Date: Gross Description: Pancreas and duodenum, pancreaticoduodenectomy: - Pancreatic ductal adenocarcinoma, moderately differentiated, 3.5 cm in greatest dimension, limited to pancreas (see worksheet) IcD.0-3 - Perineural invasion identified. isun csureereme, duet Nio5 - Resection margins negative for malignancy 0 25 O - Metastatic carcinoma in two of nine lymph nodes (2/9) AJ5(i(J1<) Microscopic Description: Diagnosis Details: Comments: Tumor Site (check all that apply): Pancreatic head Tumor Size: Tumor size greatest dimension: 3.5cm Histologic Type: Ductal adenocarcinoma Histologic Grade: G2: Moderately differentiated AJCC Stage (pTNM) Primary Tumor (pT): pT2 Regional Lymph Nodes (pN): N1b Number of regional lymph nodes involved: 2 Number of regional lymph nodes examined: 9 Distant Metastasis (pM): pMX Margin(s) negative for invasive carcinoma Angiolymphatic Invasion (V/L): Absent Perineural Invasion: Present. Formatted Path Reports: PANCREAS TISSUE CHECKLIST Specimen type: Whipple resection Tumor site: Head
+
+--- Page 2 ---
+Tumor size: 3.5 cm Histologic type: Adenocarcinoma, ductal type. Histologic grade: Moderately differentiated. Tumor extent: Not specified. Lymph nodes: 2/9 positive for metastasis (Regional 2/9) Lymphatic invasion: Absent Venous invasion: Absent Margins: Uninvolved Evidence of neo-adjuvant treatment: Not specified. Additional pathologic findings: Not specified. Comments: None W11814
\ No newline at end of file
diff --git a/output/text/63581742-f6c1-4608-8eee-1bdb871616dc.txt b/output/text/63581742-f6c1-4608-8eee-1bdb871616dc.txt
new file mode 100644
index 0000000000000000000000000000000000000000..42f3050802d5b75e41bdf8d8539e5a94494576e3
--- /dev/null
+++ b/output/text/63581742-f6c1-4608-8eee-1bdb871616dc.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+1cd-0-3 Caicinoma, mfiltnatng duct, NOS 8500|3 10/8f0 lu CQcF Iite. brsst, Nos c50.9 TSS:  UUID:DC8FD7C7-A908-4890-860F-04984244167C TCGA-E2-A14V-01A-PR Redacted SPECIMENS: A. EXCISION LEFT BREAST B. LEFT AXILLARY SKIN TAG C. LEFT AXILLA S.L.N. #1 D. LEFT AXILLA S.L.N. #2 E. LEFT AXILLARY CONTENTS SPECIMEN(S): A. EXCISION LEFT BREAST B. LEFT AXILLARY SKIN TAG C. LEFT AXILLA S.L.N. #1 D. LEFT AXILLA S.L.N. #2 E. LEFT AXILLARY CONTENTS GROSS DESCRIPTION: A. EXCISION LEFT BREAST Received fresh labeled with the patient's identification, "Excision Left Breast" is a 130g, 8 x 11 x 4cm oriented (Single-Anterior, Double-Lateral, Triple-Superior) left lumpectomy with 5 x 2 cm tan pink unremarkable skin ellipse.. Ink Code: Anterior-Yellow, Posterior-Black, Medial-Green, Lateral-Red, Superior-Blue, Inferior-Orange. The. specimen is serially sectioned from medial to lateral into 8 slices to reveal a 3 x 3 x 2.3cm gray white firm ill defined. mass, 0.5cm from the closest anterior-superior margins in slices 3-6. A portion of the specimen is submitted for tissue procurement. Representative sections are submitted as follows: A1: medial margin slice 1 A2-A3: superior margin slice 2 A4: area next to mass slice 2 A5: skin slice 3 A6: mass with anterior margin slice 3 A7: mass with deep margin slice 3 A8: mass with anterior margin slice 3 A9: mass with deep margin slice 3 A10: anterior/superior margin slice 4 A11: superior margin slice 4 A12: mass with anterior margin slice 4 A13: mass with deep margin slice 4 A14: mass with anterior margin slice 4 A15: mass with anterior/inferior margin slice 4 A16: mass slice 4 A17: deep margin slice 4 A18: deep/inferior margin slice 4 A19: mass with anterior margin slice 5 A20: superior margin slice 5 A21: mass slice 5 A22: mass with deep margin slice 5 A23-A24: anterior margin slice 5 A25: mass slice 5 A26-A27: mass with deep margin slice 5 A28-A29: mass with anterior margin slice 6 A30-A31: mass slice 6 A32: deep margin slice 6 A33: next to mass slice 7 A34-A35: deep margin slice 7 A36: lateral margin slice 8 B. LEFT AXILLARY SKIN TAGS  Received in formalin are two polypoid skin tags, 0.1 and 0.3 cm in diameter. Submitted entirely in cassette B1.. C. LEFT AXILLARY SLN #1 Received fresh is a tan pink lymph node 1.0 x 0.6 x 0.3cm. The specimen is bisected and a touch prep is taken. Toto. C1. D. LEFT AXILLARY SLN #2  Received fresh is a tan pink lymph node 1.5 x 1.2 x 0.6cm. The specimen is bisected and a touch prep is taken. Toto D1.
+
+--- Page 2 ---
+E. LEFT AXILLARY CONTENTS Received in formalin is a piece of yellow-tan adipose tissue, 9.5 x 0.5 x 2.7 cm. Multiple lymph nodes are identified ranging in size from 0.1 to 2.7 cm. The larger lymph nodes are bisected and have variegated pink-tan coloration. There is a blood vessel, 0.9 cm and the length and 0.4 cm in diameter, which is clipped at both ends. It contains blood clot. Specimen is submitted entirely:. E1-E2: 6 lymph nodes each E3-E5: 2 lymph nodes each E6-E8: 1 lymph node each E9-E10: 1 lymph node E11-E25: remainder of soft tissue DIAGNOSIS: A. BREAST, LEFT, WIDE LOCAL EXCISION: - !NVASLVE_DUCTAL CARCINOMA, POORLY DIFFERENTIATED (SBR GRADE 3). - INVASIVE CARCINOMA MEASURES 3 CM IN GREATEST DIMENSION - MARGINS, FREE OF TUMOR. - LYMPHVASCULAR INVASION IS PRESENT. - DUCTAL CARCINOMA IN SITU (DCIS), SOLID AND MICROPAPILLARY  TYPES, NUCLEAR GRADE 3, WITH NECROSIS AND MICROCALCIFICATIONS. - DCIS IS WITHIN 3 MM OF THE SUPERIOR MARGIN AND IS WITHIN 4 MM OF THE POSTERIOR MARGIN. - SKIN, NO TUMOR SEEN B. AXILLA, LEFT, SKIN TAG, EXCISION: - ACROCHORDONS. C. SENTINEL LYMPH NODE #1, LEFT AXILLA, BIOPSY: - METASTATIC CARCINOMA (0.3 CM IN SIZE) TO ONE LYMPH NODE (1/1). D. SENTINEL LYMPH NODE #2, LEFT AXiLLA, BIOPSY: - METASTATIC CARCINOMA (1.5 CM IN SIZE) TO ONE LYMPH NODE WITH  FOCAL EXTRANODAL EXTENSION (1/1). E. AXILLARY CONTENTS, LEFT, DISSECTION: - METASTATIC CARCINOMA (0.8 CM IN SIZE) TO ONE OF 22 LYMPH NODES (1/22). SYNOPTIC REPORT - BREAST Specimen Type: Excision Needle Localization: No Laterality:  Left Invasive Tumor: Present Multifocality: No WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Tumor size: 3cm Tumor Site: Lower inner guadrant Margins: Negative Distance from closest margin: 0.5cm anterior Tubular Score: 3 Nuclear Grade: 3 Mitotic Score: 3 Modified Scarff Bloom Richardson Grade: 3 Necrosis: Absent Vascular/Lymphatic Invasion: Present Lobular neoplasia: None Lymph nodes: Sentinel lymph node and axillary dissection Lymph node status: Positive 3 / 24 Extranodal extension. DCIS present  Margins uninvolved by DCIS DCIS Quantity: Estimate 40% DCIS Type: Solid Micropapillary DCIS Location:Associated with invasive tumor Nuclear grade: High Necrosis: Present
+
+--- Page 3 ---
+Location of CA++: DCIS Stroma ER/PR/HER2 Results ER: Positive PR: Positive HER2: Pending Pathological staging (pTN): pT 2 N 1 CLINICAL HISTORY: 5cm tumor-Invasive Cancer on Core Bx. Lower Inner Quadrant Left Breast.. PRE-OPERATIVE DIAGNOSIS: Left breast cancer. INTRAOPERATIVE CONSULTATION: A. GROSS INSPECTION: 3cm mass, 0.5cm from the closest Anterior margin. TPC-TPD: Positive for Adenocarcinoma. Diagnoses called to Dr. at (A) and C-Dby Dr ADDENDUM: SYNOPTIC REPORT - BREAST HER-2 RESULTS Specimen:  Surgical Excision Block Number: A16 Interpretation: POS!TIVE Intensity: 3+ % Tumor Staining: 100% Fish Ordered: No METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no iess than 8 and nn Innna ar than 24 hours. Her2 analysis was performed using the FDA approved Dako HercepTest (TM) test kit using rabbit anti- human HER2. This assay was not modified. External kit-slides provided by the manufacturer (cell lines with high,. low and negative HER2 protein expression) and in-house known HER2 amplified controi tissue were evaluated along with the test tissue. Adequate, well preserved, clear-cut invasive carcinoma was identified for HER2 evaluation. Interpretation of the HER2 immunohistochemical stain is guided by published results in the medical literature,. information provided by the reagent manufacturer and by internal review of staining performance.. This assay has been validated according to the 2007 joint recommendations and guidelines from ASCO and CAP and from the NCCN HER2 testing in Breast Cancer Task Force. The Pathology Department takes full responsibility for this test's performance. Gross Dictation: Pathologist. Microscopic/Diagnostic Dictation: Patholoaist. Final Review: Pathologist, Final Review: Pathologist. Final: Pathologist,  Addendum: Pathologist Addendum Final: Pathoiogist, 1
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diff --git a/output/text/6372f4a0-b94f-4148-8e05-ef87878678ff.txt b/output/text/6372f4a0-b94f-4148-8e05-ef87878678ff.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c61653511ab02b6aae356be4076fcc5d835dddea
--- /dev/null
+++ b/output/text/6372f4a0-b94f-4148-8e05-ef87878678ff.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UUID:09A86147-EB23-489F-9849-9FDC91AC44A1 TCGA-3L-AA1B-01A-PR Redacted MRN: Patient: Sex/DOB:  Female Admission Date: Discharge Date: Ordering Physician: Pathology Addendum Report Collected Date/Time: Accession Number: Received Date/Time: Addendum Report DNA MISMATCH REPAIR TESTING BY IMMUNOHISTOCHEMISTRY FOR THE ASSESSMENT OF MICROSATELLITE INSTABILITY: INTERPRETATION: - NO DEFICIENCY IDENTIFIED IN THE DNA MISMATCH REPAIR PROTEINS TESTED (INTACT DNA MISMATCH REPAIR FUNCTION, MICROSATELLITE STABLE, MSS) CECE ICD o r3 RESULTS: MLH1: PRESENT p.tK PMS2: PRESENT 82k3|3 MSH2: PRESENT MSH6: PRESENT Ste. Ceeun @18.0 J q124/4 NOTE: Microsatellite instability is not detected in the carcinoma by immunohistochemistry; therefore, the likelihood that the carcinoma is due to sporadic or hereditary (i.e.: Lynch syndrome-associated) defective DNA mismatch repair is very low. However, immunohistochemistry may not detect rare polymorphisms or missense mutations in DNA mismatch repair proteins in up to 10% of cases. If strong clinical suspicion persists, additional testing is suggested.. Archived slides and paraffin blocks were reviewed for case block A10 containing normal tissue and carcinoma was selected for MSI analysis. Immmunohistochemical studies were performed on formalin fixed, paraffin-embedded tissuc with adequate positive and negative control sections, including internal positive control tissue. The performance characteristics of these antibodies were determined by the :. They have not been cleared or approved by the U.S. Food and Drug Administration. The FDA hase determined that such clearance or approval is not necessary. These tests are used for clinical purposes. Thcy should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA-88) as qualified to perform high-complexity clinical laboratory testing. REFERENCE: Printed by: Page 1 of 5 Print Date/Time: Copied to: Distribute to: Patient Locations:
+
+--- Page 2 ---
+MRN: Patient: Sex/DOB: Female Pathology Addendum Report Collected Date/Time: Accession Number: Received Date/Time: Geisbach KB, Samowitz WS. Microsatellite instability and colorectal cancer. Arch Pathol Lab Med. 2011(Oct);135:1269-77 (Electronic signature) Verified: Surgical Pathology Report Collected Date/Time: Accession Number: Received Date/Time: Final Diagnosis RIGHT COLON, RIGHT COLECTOMY: ADENOCARCINOMA, MODERATELY TO POORLY DIFFERENTIATED, INVASIVE INTO MUSCULARIS PROPRIA, ARISING AS MULTIPLE FOCI IN A TUBULOVILLOUS ADENOMA WITH HIGH GRADE DYSPLASIA AND MULTIPLE FOCI OF INTRAMUCOSAL CARCINOMA - NO TUMOR SEEN IN TWENTY-EIGHT LYMPH NODES. - MARGINS OF RESECTION ARE FREE OF TUMOR. - SEE SYNOPTIC REPORT AND NOTE. (Electronic signature) Verified: Synoptic Report SPECIMEN: Terminal ileum Cecum Appendix Ascending colon PROCEDURE: Right hemicolectomy SPECIMEN LENGTH: Specify: 23 cm TUMOR SITE: Cecum TUMOR SIZE: Greatest dimension: 4.5 cm. Additional dimensions: 4.5 x 1.6 cm MACROSCOPIC TUMOR PERFORATION: Not Identified HISTOLOGIC TYPE Page 2 of 5 Print Date/Time:
+
+--- Page 3 ---
+MRN: Patient: Sex/DOB:  Female Surgical Pathology Report Collected Date/Time: Accession Number: Received Date/Time: Adenocarcinoma HISTOLOGIC GRADE: High-grade (poorly differentiated to undifferentiated). HISTOLOGIC FEATURES SUGGESTIVE OF MICROSATELLITE INSTABILITY:  Intratumoral Lymphocytic Response (tumor-infiltrating lymphocytes) None  Peritumor Lymphocytic Response (Crohn-like response)  Mild to moderate Tumor Subtype and Differentiation Mucinous tumor component (Percentage: 15 %) MICROSCOPIC TUMOR EXTENSION:S Tumor invades muscularis propria DISTAL MARGIN: Uninvolved by invasive carcinoma CIRCUMFERENTIAL (RADIAL) OR MESENTERIC MARGIN:S Uninvolved by invasive carcinoma TREATMENT EFFECT: No pricr treatment LYMPHATIC (SMALL VESSEL) INVASION (L): Not identified PERINEURAL INVASION: Not identified TUMOR DEPOSITS (discontinuous extramural extension): Not identified TYPE OF POLYP IN WHICH INVASIVE CARCINOMA AROSE: Tubulovillous adenoma (with high grade dysplasia, multiple foci of intramucosal carcinoma and multifocal invasive. carcinoma.) PRIMARY TUMOR (pT):  pT2: Tumor invades muscularis propria. REGIONAL LYMPH NODES (pN): pN0: No regional lymph node metastasis. Number examined: 28 Number involved: 0 DISTANT METASTASIS (pM): Not applicable ANCILLARY STUDIES: Microsatellite instability (testing method: IHC, pending, results will be reported in an addendum ). NOTE: tumor size corresponds to the macroscopic measurement of the tubulovillous adenoma which harbours diffuse high grade dysplasia, multiple foci of intramucosal carcinoma and multiple foci of invasive carcinoma. MSI-IHC will be reporetd in an addendum. Source of Specimen A Right Colon Page 3 of 5 Print Date/Time:
+
+--- Page 4 ---
+MRN: Sex/DOB: Patient: Female Surgical Pathology Report Collected Date/Time: Accession Number: Received Date/Time: Clinical Information PRE-OP DIAGNOSIS: Right colon neoplasm POST-OP DIAGNOSIS: Same TYPE OF PROCEDURE: Hand assisted laparoscopic, right colectomy Gross Description The specimen is labeled "RIGHr COLON "and is received unfixed. It consists of terminal ileum measures 5 cm in length and 3.5 cm. in greatest circumference, colon measures 18 cm in Iength and 8 cm in greatest circumference, appendix measures 8.5 cm in length. and 0.7 cm in greatest diameter. The serosa is congested covered by mesocolonic fat measures 34 cm thickness. Upon opening, the. Iumen contains fecalith material. There is a friable, polypoid, centrally ulcerated pink-tan mass measuring 5.5 x 4.5 x 1.6 cm. The masses and the proximal colon, 2 cm from ileocecal valve, 7 cm from the proximal margin of resection and 11 cm from the distal. margin of resection. The mass invades the muscularis propria, approximately 3 cm from the radial margin. The colon mucosa is congested with a focal black discolored area surrounding the mass. The ileocecal valve is unremarkable The terminal ileum mucosa is congested with no lesions. There are few diverticulum with no gross evidence of perforation. The appendix serosa is congested. The. wall is intact. The lumen is narrow, contains fecalith material. There are 20 lymph nodes ranging from 0.4-1.2 cm in maximum dimensions. Representative sections are submitted, the entire mass is submitted.. Section Key: A1-proximal margin A2-distal margin A3-mass with deepest margin A4-A21 mass A22-black mucosa surrounding mass. A23-diverticulum A24-random sections of colon A25-random sections of terminal ileum and ileocecal valve. A26-appendix A27-one lymph node bisected A28-one lymph node bisected A29-one Iymph node bisected A30-one lymph node bisected A31-one lymph node bisected A32-one lymph node bisected A33-three lymph nodes. A34-four lymph nodes A35- five lymph nodes. A36-six lymph nodes A37-five lymph nodes. The specimen is in formalin for more than 6 hours and iess than 72 hours. Time specimen was removed from the patient: Time specimen was placed in formalin :. Page 4 of 5 Print Date/Time: :
+
+--- Page 5 ---
+MRN: Patient: Sex/DOB:  Female Surgical Pathology Report Collected Date/Time: Accession Number: Received Date/Time: Ischemic time: 1 hour 31 minutes Dictated by: Special Stains / Slides. 37 H&E Tissue Code Page 5 of 5 DISQUALIFIED
\ No newline at end of file
diff --git a/output/text/63a102fa-5948-4c0b-9663-5ab47d5499da.txt b/output/text/63a102fa-5948-4c0b-9663-5ab47d5499da.txt
new file mode 100644
index 0000000000000000000000000000000000000000..94f9a436afd6ca025edbf98cbe3c22dcdc2f5646
--- /dev/null
+++ b/output/text/63a102fa-5948-4c0b-9663-5ab47d5499da.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:AC60F58B-9371-4F69-BAA0-099AD7FC2A0B TCGA-A2-A25F-01A-PR Redacted 1Cs-0-3 Carcinoms nfiltrutivg duct, Nos 8500f3 Sit: brust, Nos c50.9 4/37/ n SUrGICAL REPORTS Name: . Pathology Numbe!d Sex: F Date Collected: DOB: Date Received: Location: M.R. Number. Doctor. Account Number  Pre-OPeRAtive DiAGNosis RIGHT BREAST CA post-Operative DiAgnoSis RIGHT BREAST CA PROCEDURE Right Breast LumpecTomy with SEntineL Lymph nOde BiOpsy. f.S.: POssiBle AXIlLAry DissEctIon, POssiBLe SAVI PREP DEVICE INSERTION tIssues A. SENTINEL LYMPH NODE (S) - RIGHT SENTINEL LYMPH NODE #1 * B. SENTINEL LYMPH NODE (S) - RIGHT SENTINEL LYMPH NODE #2 * C. BREAST EXCISION,NEEDLE LOC,SIMPLE,MARGINS,ETC: - RIGHT BREAST LUMP FS DIAGNOSIS A. Right SenTineL Lymph node #1, ONe negAtive node (0/1). B. Right sentinel. Lymph node #2, One negative node (0/1). c. Right bReAst LuMP (GRO$s mArgiNs) - THe TUmOR mA5s MeAsures 2.6 Cm. iN mAXImUm DimeNsION And ALl SurgiCAL Margins are free of Lesion. (reported to surgeon: Dlagnosed by. FINAL DIAGNOSis A. Right Sentinel Lymph node #1 -- One reactive lymph node (0/1). B. Right SenTineL Lymph NODe #2 - One reactive lymph node (0/1). C. Right breast lump -- inFILTrATive Duct carc(noma (26 cm.) SCARFF-BLOOM-RICHARDSON GRADING: GRADe iI Of Hi (ABSENT TUBULE fORmATiONS, high gRADE nuCLEAR Features and high mitotic index). ANGIOLYMPHATIC INVASION: Patiant Name: Pathology Number: SURGICAL REPORT Paae 1 of 3
+
+--- Page 2 ---
+Patient Name Pathology Number: PrOBable.d DCis/AtypicAl DuctAl hypeRPlAsiA: PreSent, CRibRIfOrm pattern, high GraDe nucLeAR features AND Comprise Asout 6% of the tumor. SURGICAL MARGINS: UninVoLVED. NON-nEOPLAstiC breAst: FiBrocystic changes with microcalciFication. MAmmaRy Vessel MeDial CalcIfication. Dlngn osed by. . M.D., Pathologikt Reviewed and eloctronically signod out by. COMMENT The ER, PR and Her-2/neu (IHC) have been performed on surgical This case is discussed with Dr. by Dr. COMMEnT2  Immunohistochemical (iHC) stain for panKeratin (AE1/AE3) is negative for micrometastases in right sentinel lymph nodes (biocks FSA, A, FSB, B). GROSS DEsCRIpTIOn The specimen is received in three separate contalners labelec Jesignated A, B, c. A The container is received fresh unfixed labeled "right sentinel lymph node #1 for frozen section" and consists of an ovoid mass of apparent fat which is 1 x 0.6 x 0.4 cm. Sectioning reveals a 0.3 cm. tan-gray firm nodule. Frozen section is obtained by Dr.. The entire specimen including frozen section is submitted In two blocks. B The container is received fresh unfixed labeked *right sertinel lymph node #2 for frozen section* and consists of an irregular mass of apparent fat which is 0.6 x 0.4 x 0.4 cm. Sectioning reveals a thin rim of tan-gray firm rubbery tissue 0.4 x 0.3 x 0.2 cm. Frozen section is obtained by Dr The entire specimen including frozen section is submitted in two blocks.. C. The container is received fresh unfixed labeied *right breast lump' and oonsists of a 26 gm. ovoid mass of apparent fatty and fibrous-encased tissue which is 5.5 x 4 x 3.5 cm. in greatest overall dimension. There are two short sutures indicating superior margin inked with red dye, inferior is inked yellow. There is a single long suture indicating iateral margin inked with green dye, medlal is Inked blue. There is a single short suture indicating anterior margin inked with orange dye, posterlor/deep is inked black. Sectioning reveals a tumor mass 2.5 x 2.3 x 1.5 cm. in greatest overall dimension and grossly appears to be 0.4 cm. from the superior, Q.5 cm. from the inferior, 1 cm. from the laterai, 0.8 cm. from the mediai, 0.8 cm. from the anterior, and 0.5 cm. from the posterior. The entire specimen is submitted in sixteen blocks. Note:Gross margins are observed by Dr. . Gross margins are free. The ciosest margin is superior which is about 4 mmm. Patlent Narme Pathology Number:d SURGICAL REPORT Page 2 of 3
+
+--- Page 3 ---
+Patiant Narr Pathology Number: Key Note Block Sunmary. 1--- superior, 2---interlor, 3-- lateral, 4- medial, 5-- -anterior, 6--- posterior (all are perpendicular). 7 through 16---remaining. (fixation time 9:28 a.m.) MiCrOsCOPic ExAm Synoptic report: Specimen Laterality: Right Procedure:  Excision w/o wire-guided loc Specirnen Integrity: Single intact speclmen Lymph Node Sampling: Sentinel tymph nodes Specimen Size: 5.5 x 4 x 3.5 cm. Invasive Carcinoma Size: 2.5 cm. Tumor Focality: Single Extent of Tumor: Skin not present  No skeletal muscle present in-situ Component DCIS Histologic Type. Ductal Histologic Grade: 3 Glanduar/T ubutar Differentiation: 3 Nuclear Pleomorphism: 3 Mitotic Count 3 Margins:  Margins uninvolved by invasive carcinoma Distance from closest margin: 4 mm, superior Margins uninvolved by DCiS Lymph Nodes: 2 SLN examined 2 Total LN examined Pathologic Staging: pT2 pNO MX ER: 0% PR: 2% Her-2/neu IHC: Negative  MIcrOscOpic exAmInaTIOn COnDucteD by pathOlOgiSt CONF!rms FiNAL DIAgnOSis. SPECIAL STAINS PERFORMED. Cytokeratin (AE1/AE3) (specimens A&B) (r -- Patiant Name Pathology Number: SURGICAL REPORT Page 3 of 3
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diff --git a/output/text/63b7bc8b-521a-4818-932f-f0bead3e0b7c.txt b/output/text/63b7bc8b-521a-4818-932f-f0bead3e0b7c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1ceb4c5392a937d6a5cebb8690d642b0c8c603af
--- /dev/null
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+
+--- Page 1 ---
+ICD-o-3 Lolendesrsromo, NoS Pathology Reporte 8/40/3 Coded sample ID: Site: Ceeyshague, chital thlel7 Ci5 5 Date of tumor procurement: ) 1/29/14 Date of report: Histologic diagnosis: moderate/poor differentiated adenocarcinoma in Barrett-epithelium Anatomic site with laterality: distal esophagus Tumor size: diameter 5 cm Lymph node status: 5 lymph nodes, of which 3 contains tumor UUID:5D0508E6-8DA2-4851-B00A-1B54AA6CC20D CGA-2H-A9GK-01A-PR Redacted Any comments or amendments: radical resection
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diff --git a/output/text/64474b19-1313-493d-8d36-4da6c1e12f4d.txt b/output/text/64474b19-1313-493d-8d36-4da6c1e12f4d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..253ee5d9ab37f96f587200be528c6181ef77861a
--- /dev/null
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+
+--- Page 1 ---
+Ics-0-3 cacinom, mfi1fratmg 1obulu, Nos 8520/3 bw Site: srst, nos c50.9. 8/18/  Final Diagnosis A. Lymph node, left axillary sentinel No. 1, biopsy: A single left axillary sentinel lymph node is negative for metastatic carcinoma. Blue dye is identified. Immunohistochemical cytokeratin stain was performed on the paraffin embedded sentinel lymph node tissue and confirms the H&E impression. B. Lymph node, left axillary sentinel No. 2, biopsy: A single left axillary sentinel lymph node is negative for metastatic carcinoma. Blue dye is identified. Immunohistochemical cytokeratin stain was performed on the paraffin embedded sentinel lymph node tissue and confirms the H&E impression. C. Breast, left, simple mastectomy: Infiltrating lobular carcinoma, Nottingham grade I (of III) [tubules 3/3, nuclei 1/3, mitoses 1/3; Nottingham score 5/9] is identified forming a 0.9 x 0.7 x 0.5 cm mass located in the lower outer quadrant of the breast. Ductal carcinoma in situ is absent. Lobular carcinoma in situ is present. Angiolymphatic invasion is absent. The non-neoplastic breast parenchyma shows fibrocystic changes and a hyalinized fibroadenoma (0.6 x 0.4 x 0.4 cm, lower inner quadrant). Calcifications present in benign ducts and acini. Biopsy site changes present. The tumor does not involve the nipple, overlying skin, or underlying chest wall. All surgical resection margins, including the deep margin, are negative for tumor (minimum tumor free margin, 0.2 cm, anterior margin). With available surgical material [AJCC pT1bN0(i-)(sn)] D. Lymph node, right axillary sentinel No. 1, biopsy: A single right axillary sentinel lymph node is positive for isolated tumor cells (less than 200 cells) on H&E and cytokeratin immunostaining. Blue dye is identified.. E. Lymph node, right axillary sentinel No. 2, biopsy: A single right axillary sentinel lymph node is negative for metastatic carcinoma. Blue dye is not identified. Immunohistochemical cytokeratin stain was performed on the paraffin embedded sentinel lymph node tissue and confirms the H&E impression.. F. Lymph node, right axillary, biopsy: A single right axillary lymph node is negative for tumor. G. Breast, right, simple mastectomy: Infiltrating lobular carcinoma, Nottingham grade I (of III) [tubules 3/3, nuclei 1/3, mitoses 1/3; Nottingham score 5/9] is identified forming a 12.5 x 6.3 x 2.2 multinodular, irregular, ill-defined mass with biopsy site changes involving multiple quadrants from the Iateral aspect of the breast to the upper inner quadrant. Ductal carcinoma in situ is absent. Lobular carcinoma in situ is present. Angiolymphatic invasion is absent. The non- neoplastic breast parenchyma shows fibrocystic changes. Calcifications present in benign ducts and acini. Biopsy site changes present. The tumor does not involve the nipple, overlying skin, or underlying chest wall. All surgical resection margins, after re-excision of the deep margin (see part H), are negative for tumor (minimum tumor free margin, 0.2 cm, deep margin). With available surgical material [AJCC pT3N0(i+)(sn)]. H. Breast, new right inferior-lateral chest wall margin, re-excision: Invasive lobular carcinoma present within the tissue, located 0.2 cm from the new deep margin. UUID:C3537961-4636-4BD1-BC89-892580836E43 TCGA-AR-A2LQ-01A-PR Redacted
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diff --git a/output/text/646a3ab7-8127-4bf7-94ff-e7f2636bdea5.txt b/output/text/646a3ab7-8127-4bf7-94ff-e7f2636bdea5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8eba473e328313f8e4b71a4c0586d9e0f3dd442d
--- /dev/null
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+
+--- Page 1 ---
+page 1 / 2 Department of Cancer Pathology copy No. Date: Examination: Histopathological examination. Internal invoice No.. Cost of diagnostic proceduree Examination No.:e Patient: xxx PESEL: XXX Age: Gender: F Material: Multiple organ resectio.1 -- right breast with axillary tissues 1cs-0-3 Unit in charge: Carcmonn) nfi(tnstny duct,Nos 8500j:3 Physician in charge: Shte : brsot, nos c50.9 Material collected on: Material received on: Expected time of examination: up to 8 working days. Clinical diagnosis: Cancer of the right breast. Examination performed on:. Results of immunohistochemical examination: Estrogen receptors found in over 75% of neoplastic cell nuclei.. Progesterone receptors found in 10-75% of neoplastic cell nuclei.  HER2 protein stained with HercepTestTM by DAKO. Positive reaction in invasive carcinoma cells (Score = 3+) Compliance validated by: Examination performed on: :. Macroscopic description: Right breast sized 23 x 18 x 4 cm removed along with axillary tissues sized 12 x 8 x 3.5 cm and a skin flap of 21 x 11 cm. Weight 700 g. Tumour sized 4.5 x 3.5 x 3 cm found on the boundary of outer quadrants, located 4.2 cm from the ouer boundary, 0.5 cm from the base and 1.7 cm from the skin.. Microscopic description: Carcinoma invasivum (partim signet ring cell carcinoma) - NHG2 (3+3+1/7 mitoses/10 HPF - visual area 0.55mm). Glandular tissue showing parenchymal atrophy. Axillary lymph nodes:  Metastases et micrometastases carcinomatosae in lymphonodis (No xiv/xvi). Infiltratio capsulae lymphonodorum et telae perinodalis. Emboliae carcinomatosae vasorum. Histopathological diagnosis:e Carcinoma invasivum mammae dextrae. Metastases et micrometastases carcinomatosae in lymphonodis axillae (No xIv/xvI). (NHG2; pT2; pN3a). Fina! diagnosis to be given after supplementary tests.. Compliance validated by: Examination performed on UUID:449F70F0-DFE1-40F9-879D-43283CFAF5250 TCGA-D8-A1X5-01A-PR Redacted
+
+--- Page 2 ---
+page 2 / 2 Examination: Histopathological examination Examination No.:. PESEL: XXX Gender: F Patient: xxx Examination performed or Examination result/Final Histopathological diagnosis: Carcinoma ductale invasivum mammae dextrae. NHG2, pT2, pN3a. Invasive ductal carcinoma.of the-right-breast NHG2, pT2, pN3a. Immunophenotype: CK7-, CK 5/6-, GCDFP-15-, E-cadherin+, PAS+ Compliance validated L CONTACT YOUR DOCTOR WITH THIS REPORT!
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diff --git a/output/text/64825ada-8471-4671-9bbe-0fc670e631c8.txt b/output/text/64825ada-8471-4671-9bbe-0fc670e631c8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d85e203354dccd880f355ad857030bc5371241bc
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+TSS ID TSS ID.. OC ID Date of Procurement: Gross Description: Breast with the tumor of 2.8 x2.6 cm in size; lymph nodes are up to 1 cm in their diameter, dense, hyperemic. Microscopic Description: Infiltrating duct carcinoma; G2. Ten examined lymph nodes demonstrate sinus histiocytosis. Diagnosis Details: Tumor Features: Unknown, Tumor Extent: T2 tumor size more than 2cm not more than 5 cm, Venous Invasion: Absent, Margins: Absent, Treatment Effect: Comments: 1cs-0-3 Formatted Path Report: Ca^cm onn,n filfrafq oluct N0s 85oof3 BREAST TISSUE CHECKLIST Sits: busot Nos C50.9 4/8/1 h Specimen type: Radical mastectomy Specimen size: Not specified. Tumor site: Lower inner quadrant Tumor size: 2.6 x 0 x 2.8 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinoma Histologic grade: Moderately differentiated Tumor extent: Not specified. Lymph nodes: 0/10 positive for metastasis (Axillary 0/10) Extracapsular invasion of the lymph nodes: Not specified Margins: Uninvolved Nottingham Histologic Score. UUID:EDDEB488-B712-40B0-9DE5-9F585791AF4D Redacted TCGA-E9-A1RD-01A-PR Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined
+
+--- Page 2 ---
+TSS iD: Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified. Comments: None Laterality: Right, lower inner quadrant.
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diff --git a/output/text/64a19983-8bf2-41c0-86eb-1d0a3b053973.txt b/output/text/64a19983-8bf2-41c0-86eb-1d0a3b053973.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d80cc8b93d5a1caa27028e2a09a1a83660352f87
--- /dev/null
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+
+--- Page 1 ---
+UALIFIED UUID:357A8CB5-F1BF-48FC-97DF-07CEF0D55026 -#/24 TCGA-EK-A3GN-01A-PR Redacted Surgical Pathology Final Report Result type: Result date: Result status: Result title: 1 Performed by: Verified by: Encounter info: * Final Report *. 10s-0-3 Caiciina,squsmons cill, No5 8O7o/3 Site: cerix NOs C53.9 b ufa9f Date Collected: SPECIMEN A: CERVIX BX SPeCImEN B: BLADDER BX CLINICAL HISTORY: SPECIMENS SUBMITTED: A. CerVIx BX B. BLaDDer BX DIAGNOSIS: CErvix; biOpSy: inVASiVE, pOORLy DIffERenTiaTED SQUAmOUS CeLl CARcinOmA. ANGIOLYmPHATiC iNVASION NOT IDENTIFIED. SPECimEN iS NEARLY ENTiRELY iNVASIVE CARCiNOMA, DEPTH OF iNVASION CANNOT BE DETERMINED, BUT TUmOR MEASURES 1.0 CM iN MICROSCOPiC SECTION. BlAdder, biopsy: SQUAMOUS METAPLASIA WITHOUT DYSPLASiA. NEGATIVE FOR CARCINOMA. ABUNDANT BLOOD CLOT WITH EXFOLiATED BUT BENIGN APPEARiNG EPITHELiAL CELLS. BIOPSY CONTAINS NO MUSCLE CONSISTENT WITH MUSCULARIS PROPRIA. InTRA-OPERATIVE DIAGNOSIS: Cervical biopsy: Invasive squamous cell carcinoma. CLINICAL INFORMATION: '-year old female with large cervical leslon consistent with cervical cancer. Gross Description:  There are two containers, each labeled with the patient's name and medical record number. Printed by: Page 1 of 5 Printed on: (Continued)
+
+--- Page 2 ---
+Surgical Pathology Final Report Labeled "cervical biopsy, frozen section". Received unfixed are multiple. portions of gray to pink-tan soft tissue aggregating to 3.0 x 3.0 x 1.3 cm. Representative sections are submitted for frozen section and resubmitted. for permanent in cassette A1. Additional tissue is submltted for. study 136 per consent from the patlent. The remaining tissue is wrapped and submitted for permanent in cassette A2. Labeled "bladder biopsy'. Recaived is an irregular portion of pink-tan soft tissue admixed with hemorrhagic material aggregating to 0.8 x 0.5 x. 0.2 cm. Tne specimen is wrapped and submitted en toto in cassette 81.. MICROSCOPIC DESCRIPTION: Histologic examination performed. TumOr StagiNg fOrm: CERVIX UTERI AMERICAN JOINT COMMITTEE ON CANCER STAGING MANUAL SIXTH EDITION 2002 DEFINITIONS Primary Tumor (T) Ctin Path TNM FlGO Categories Stages Deflnitions. [] [X] TX Primary tumor cannot be assessed TO No evidence of primary tumor Tis 0 Carcinoma in situ T1 Cervical carcinoma confined to uterus (extenslon to corpus should be disregarded) [] [] T1a 1A Invasive carcinoma dlagnosed only by microscopy. (Note 1:The depth of invasion Is defined as the measurement of the tumor from the epithelial-stromal Junction of the adjacent most superticial dermal papilla to the deepest point of invasion.) All macroscopically vislbie lesions - even with superficial Invaslon - are T1b/IB. Stromal invaslon with a maximal depth of 5.0 mm measured from the base of the epithelium and a horizontal spread of 7.0 mm or less. Vascular space Invoivement, venous or lymphatic, does not affect classification [] [] T1a1 1A1 Measured stromal invasion 3.0 mm or !ess in  depth and 7.0 mm or less in horizontal spread [] (] T1a2 iA2 Measured stromal invaslon more than 3.0 mm and.  not more than 5.0 mm with a horlzontal spread 7.0 mm or less [] {] T1b  1B Clinically visible lesion confined to the cervix or mlcroscopic lesion greater than T1a2/IA2 [] [] T1b1 1B1 Clinically visible lesion 4.0 cm or less in Printed by: Page 2 of 5 Printed on: (Continued) (.
+
+--- Page 3 ---
+Surgical Pathology Final Report greatest dimenslon {} [] T1b2 iB2 Clinically visible lesion more than 4.0 cm in greatest dimension [] [] T2  II Cervical carcinoma invades beyond uterus but not to pelvic wall or to lower third of vagina [] [] T2a  iIA Tumor without parametrial invasion [) [] T2b  118 Tumor with parametrial invasion l] (j t3  III Tumor extends to pelvic wall and/or involves  lower third of vagina and/or causes  nydronephrosis or non-functioning kidney. [] [] T3a llIA Tumor involves lower third of vagina, no extension to pelvic wal! [] [] T3b IiB Tumor extends to pelvic wall and/or causes  nydronephrosis or non-functioning kidney [] [] T4  IVA Tumor invades mucosa of bladder or rectum  and/or extends beyond true pelvis (bullous edema is not sufficient evidence to classify a tumor as T4) Regional Lymph Nodes (N) [] [X] NX Regional lymph nodes cannot be assessed [] [] NO  No regional lymph node metastasis [] [] N1  Regional lymph node metastasis Distant Metastasis (M)  MX Distant metastasis cannot be assessed [j mo No distant metastasis [] M1  IVB Distant metastasis Biopsy of metastatic site performed []y []N Source of pathologic metastatic specimen_ Stage Grouping (AJCC/UICC/FIGO) []0 Tis NO MO 1 T1 NO MO [] IA T1a NO MO [1 IA1 T1a1 NO MO 1 IA2 T1a2 N0 MO IB T1b NO MO iB1 T1b1 NO MO IB2 T1b2 NO MO jI~T2 NO MO IIA T2a NO MO ilB T2b NO MO [] l] ml t3 NO MO IIIA T3a NO MO i]lIBT1 N1 MO T3a N1 MO T3b Any N M0 [] [] lVA T4 AnyN MO [j {} IVB Any T Any N M1 Printed by: Printed on: Page 3 of 5 (Continued)
+
+--- Page 4 ---
+Surgical Pathology Final Report. Histologic Grade (G) [] Gx Grade cannot be assessed (j G1 Well dlfferentiated [j G2 Moderately differentiated {X} G3 Poorly differentiated [) G4 Undifferentiated Residual Tumor (R) : [] Rx Presence of residual tumor cannot be assessed . [} RO No residual tumor [ r1  Microscopic residual tumor [] R2 Macroscopic residual tumor  ++  Additiona! Descriptors For identification of special cases of TNM or pTNM classifications, the "m" suffix and "y,""r," and "a" prefixes are used. Although they do not affect the stage grouping, they indicate cases needing separate analysis.. ! [1 m suffix indicates the presence of multiple primary tumors in a single site and is recorded in parentheses: pT(m)NM. [] y preflx indicates those cases in which classification is performed during or following initial multimodality therapy. The cTNM or pTNM category is identified by a "y prefix. The ycTNM or ypTNM categorizes the extent of tumor actually present at the time of that examination. The "y' categorization is not an estimate of tumor prior to multimodality therapy.. [] r prefix indlcates a recurrent tumor when staged after a disease-free interval, and is identified by the "r" prefix: rTNM. [I a prefix designates the stage determined at autopsy: aTNM. Notes Additional Descriptors Lymphatic Vesse! invasion (L) LO No lymphatic vessel invasion Venous Invasion (V) V0 No venous invasion. Prognostic Indicators (if applicable) Physician's Signature. Date The staff pathologist was present during the formal review and interpretation of all slldes and ancillary studies, (if performed), with the medical student or resident. Printed by: Page 4 of 5 Printed on: (Continued)
+
+--- Page 5 ---
+Surgical Pathology Final Report Rendering Diagnostician: Pathologist Electronically Signed Completed Actlon List: .- Printed by: Printed on:  Page 5 of 5 (End of Report)
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diff --git a/output/text/64a201dd-6982-463c-aa81-b208f3a418d4.txt b/output/text/64a201dd-6982-463c-aa81-b208f3a418d4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..411a878905c0ba94cca9695e400ff5df1879edce
--- /dev/null
+++ b/output/text/64a201dd-6982-463c-aa81-b208f3a418d4.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+ICD-0 -3 "UUID:B16DE561-4A84-4E00-AFF8-CA8A5203D6D0 TCGA-DM-A1HB-01A-PR Ste: T/ansvurse- Co1oN C18.4 Redacted  (First Tumor) Tumor Site: Transverse Colon Date of Cancer Sample Procurement: Histology: Adenocarcinoma Description of other histology: : Grade: Moderately Differentiated Mucinous: C No O Yes C Yes C Unknown (Focal) Signet Ring Feature:  No  Yes r Yes r Unknown (Focal) Histologic Heterogeneity: C No  Yes C Unknown Host Response: Lymphoid Aggregates Crohn's like reaction  None  Yes  Unknown Plasma cell rich stroma C No r Yes C. Unknown Growth Pattern: C Expansile  Expansile C Invasive C Unknown and Invasive Inflammatory Bowel Disease  No C Yes C Unknown Angiolymphatic invasion:  No C Yes C Unknown Mutator Phenotype: C. No  Yes C Unknown Number of Slides 1 Garland Necrosis present: C No  Yes C Yes C Unknown (Focal) TiL Cells / HPF 2.4 Pathologist Comment:
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diff --git a/output/text/64a437f3-ad54-4197-9c91-5549a61cd479.txt b/output/text/64a437f3-ad54-4197-9c91-5549a61cd479.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c3a7b884f660f8c8df611b83b4c48c2d77464153
--- /dev/null
+++ b/output/text/64a437f3-ad54-4197-9c91-5549a61cd479.txt
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+
+--- Page 1 ---
+This is an unequivocal finding in the sense of an adenocarcinoma of the colon (Block A) of the mucinous adenocarcinoma type (thus G3), with penetration of all parietal layers and vascular infiltration, thus pT3, L1, V1, with free resection margins in the mucosal region with a regular mucosa, submucosa and muscularis, with free resection margins in the ligature region with mature mesenchymal structures, with a chronic recurrent appendicitis with fecal impaction. Tumor classification: ICDO-DA-M G 3 pT3, L1, V1, pN0 (0/14)
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diff --git a/output/text/64d21856-5d0a-46ba-856a-7222907ab8f8.txt b/output/text/64d21856-5d0a-46ba-856a-7222907ab8f8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d56d51628c8b3b06a2cde657b537748e0b8715fc
--- /dev/null
+++ b/output/text/64d21856-5d0a-46ba-856a-7222907ab8f8.txt
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+
+--- Page 1 ---
+SURGICAL PATHOLOGY REPORT SPECIMEN A. Liver lesion B. Paraaortic lymph node. Rectosigmoid colon CLINICAL NOTES CLINICAL HISTORY: Sigmoid colon cancer.. FROZEN SECTION DIAGNOSIS left lobe, excision: Metastatic adenocarcinoma GROSS DESCRIPTION A.  The specimen is received fresh for frozen section Left liver lesion" and consists of a tan 0.8 x 0.3 x 0 rubbery tissue, entirely frozen as frozen section n formalin labeled "paraaortic lymph node" is. a 1.2 x 0.8 x 0.3 cm. rubbery tan pink tissue in keeping with lym de which is quadrisected and entirely submitted in one block Received fresh for tissue for permanent labeled rectosiqmoid colon" is a previously unopened, 22 cm. segment of distal colon, surfaced by smooth glistening tan-pink serosa and scabrous adventitia, with an abundant amount of attached mesocolon. The specimen is oriented by anatomic landmarks and both. proximal and distal margins average 8.5 cm.. in circumference. On opening, there is a a circumferential, 7.8 x 4.6 cm. centrally necrotic rubbery, tan-red tumor mass, with raised rolled edges located 5.5 cm. from the distal margin.  A portion of tumor and a portion of normal mucosa submitted for tissue procurement requested.  On sectioning, the tumor extends into the muscularis to within 0.2 cm. of the inked free radial serosal surface (see blocks #3 and 4).  The tumor is greater than 5 cm. from the adventitial resection margins (represented in block #2).  The mucosa throughout the remainder of the specimen is focally tattooed tan-pink to gray-black, with regular folds in the wall averages 6.0 cm. in thickness. No additional mass lesion or abnormality is identified grossly tissues in keeping with lymph nodes measuring up to 1.2 cm. are recovered from the attached mesocolon. entative sections are submitted in fifteen blocks as labeled. BLOcK suMMARY: #1 - Proximal and distal margins (proximal inked blue); 2 - adventitial surface adjacent to tumor (inked green); 3-5  tumor full thickness to inked free radial serosal surface; 6 tumor to normal mucosa;  random from remainder of specimen; 8-11  nine (9) whole lymph nodes assette; 12-15 - one bisected lymph node per cassette. MICROSCOPIC DESCRIPTION A, B, C. Microscopic examination of the rectosigmoid
+
+--- Page 2 ---
+resection, as well as the liver lesion and para-aortic. lymph node biopsy reveals - Histologic type: Adenocarcinoma Histologic grade:  Moderately to poorly differentiated Primary tumor (pT):  Tumor invades through muscularis propria into. subserosa (pT3) Proximal margin: Negative for tumor Distal margin: Negative for tumor Circumferential (radial) margin: Negative for tumor Distance of tumor from closest margin: 5.5 cm from the distal margin and greater than 5 cm from adventitial/radial margin Vascular invasion: Lymphatic space invasion is identified and is prominent in blocks C4 and c5. No large vessel invasion is identified. Regional lymph nodes (pN): Metastatic adenocarcinoma is identified. in 1 of 37 lymph nodes and measures 2 mm in greatest dimension in. slide C15. (pNla). Non-lymph node pericolonic tumor: Not identified.. Distant metastasis (pM): In  liver biopsy in specimen A (pMla).. Other findings: The para-aortic lymph node is negative for malignancy in specimen B.  The background colonic mucosa appears. unremarkable. 4x1, 14xl, 3x1, 5x1 DIAGNOSIS A. Liver lesion, incisional biopsy: Metastatic adenocarcinoma of colonic type consistent with origin from rectosigmoid tumor. B. Para-aortic lymph node, excisional biopsy: Single lymph node negative for metastatic tumor (0/1). Colon, rectosigmoid, segmental resection: Adenocarcinoma, moderately to poorly differentiated, invasive through muscularis propria  into subserosal tissue (pT3) Metastatic adenocarcinoma present in 1 of 37 lymph nodes (pN1a). Lymphatic space invasion present. Resection margins are negative for tumor. See microscopic description for template details..  End Of Report
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diff --git a/output/text/64e9c956-5ab5-46f3-b876-fbdcfd91104a.txt b/output/text/64e9c956-5ab5-46f3-b876-fbdcfd91104a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0657298e9a5792870c213a92d46bf5f246376cb2
--- /dev/null
+++ b/output/text/64e9c956-5ab5-46f3-b876-fbdcfd91104a.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+CGA-AU-3779 KANP FINALDIAGNOSIS OM  A. COLON, SIGMOID, RECTUM (RESECTION) : INFILTRATING WELL DIFFERENTIATED ADENOCARCINOMA ARISING IN A TUBULOVILLOUS ADENOMA (4 CM) TUMOR IS LOCATED IN THE SIGMOID, AND EXTENDS THROUGH MUSCULARIS PROPRIA TO SURROUNDING PERICOLONIC ADIPOSE TISSUE. TUMOR IS 3 CM FROM CLOSEST (OPENED) MUCOSAL MARGIN OF RESECTION, EXTENDS TO O.6 CM FROM CLOSEST SEROSAL (ANTI-MESENTERIC) SURFACE AND THE MESENTERIC RADIAL MARGIN IS 3.5 CM. SMOOTH MUSCLE PROLIFERATION IDENTIFIED IN SEROSAL ADHESIONS CONSISTENT WITH PARTIAL MYOMECTOMY AS DESCRIBED INTRA-S OPERATIVELY. ADDITIONAL FINDINGS ARE NOTED IN NON-NEOPLASTIC MUCOSA INCLUDING DIVERTICULAR DISEASE WITH RUPTURED DIVERTICULITIS ANDS ASSOCIATED SOFT TISSUE INFLAMMATION AND FIBROSIS, AS WELL AS INCIDENTAL HYPERPLASTIC POLYP (O.1 CM). ALL SURGICAL MARGINS AND TWENTY-ONE REGIONAL LYMPH NODES,  NEGATIVE FOR TUMOR. PATHOLOGIC STAGE: pT3 NO MX B. DONUTS RESECTION): HISTOLOGICALLY UNREMARKABLE SEGMENTS OF LARGE INE. CSANSYNOPTIC+REPORTAKOA SYNOPTIC REPORT:  COLON AND RECTUM (CAP/AJCC/ACS - REQUIRED ELEMENTS) SPECIMEN TYPE: PARTIAL COLECTOMY SPECIMEN SIZE: 16 CM TUMOR SITE: SIGMOID TUMOR SIZE: 4 CM HISTOLOGIC TYPE: ADENOCARCINOMA HISTOLOGIC GRADE: 1 EXTENT OF INVASION: THROUGH MUSCULAR PROPRIAS f,s.. (IF THROUGH MUSCULARIS PROPRIA, DISTANCE BEYOND:) O.1 CM f,.,, OTHER ORGANS INVOLVED/VISCERAL PERITONEUM (SPECIFY) : NONE MARGINS : f.... PROXIMAL: UNINVOLVED f.... DISTAL: UNINVOLVED f..! RADIAL MESENTERIC: UNINVOLVED (3.5 CM) f..: (IF MARGINS UNINVOLVED, DISTANCE TO CLOSEST MARGIN:) O.6 CM FROM SEROSAL ANTI-MESENTERIC
+
+--- Page 2 ---
+LYMPHATIC INVOLVEMENT (PRESENT/ABSENT) : ABSENT VENOUS (LARGE VESSEL) INVOLVEMENT (PRESENT/ABSENT) : ABSENT LYMPH NODES: f,,., #INVOLVED/#EXAMINED: 0/21 OTHER PERTINENT FINDINGS: (SEE NARRATIVE) pTNM STAGE: pT3 NO MX
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diff --git a/output/text/6509a179-0b55-464b-8425-aed101b1d4e1.txt b/output/text/6509a179-0b55-464b-8425-aed101b1d4e1.txt
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index 0000000000000000000000000000000000000000..b21f4c3588235313eb51a54f7dfc851949dc541e
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+ics-U.3 Patient: Sif fm! brut Nos C50.9 Surgical Pathalogy: Surg Path CLINICAL HISTORY:S year old white female with right subareolar breast mass times 3 month. Right breast carcinoma. GROSS EXAMINATION: of a portion of breast tissue with a skin ellipse and nipple. The skin. ellipse measures 9 x 3.5 cm. The underlying breast tissue measures 10 x 4 x 4 is a 2.5 x 2 x 1.5 cm mass composed of tan firm friable tissue with focal areas of hemorrhage.. The mass is sharply circumscribed. The mass is 0.8 cm from the deep surgical margin. Block Summary: Al: Section of nipple. A2-All: Section of mass including deep surgical margin.. MICROSCOPIC EXAMINATION: Large portions of the tumor are made up of well-formed papillary tumor with fibrovascular cores lined by malignant, stratified, complicated, epithelium.. In addition, cribriform and tubular foci infiltrate desmoplastic fibrous tissue. This case was reviewed by Dr. DIAGNOSIS: A. "RIGHT BREAST MASS- WIDE LOCAL EXCISION": INVASIVE PAPILLARY ADENQCARCINOMA OF BREAST (2.5 CM IN GREATEST DIAMETER). Verified by: 1.D. i.d. Date UUID: 8AABC46F-03C7-4FBF-AC20-2C862E303A8B Redacted TCGA-B6-A0IC-01A-PR  Result forg 1 of 1
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diff --git a/output/text/652154cd-66d7-44f5-bad4-684953ab4f15.txt b/output/text/652154cd-66d7-44f5-bad4-684953ab4f15.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9abe60f893907010721708613784cb6c032e423a
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+--- Page 1 ---
+UUID:E49FAC55-434A-429B-8E61-C5E0FBD7C15C W ai3 TCGA-GM-A5PX-01A-PR Redacted 92 DIAGNOSIS (A) LEFT BREAST, SKIN-SPARING TOTAL MASTECTOMY: TWO FOCI OF INVASIVE LOBULAR CARCINOMA, NOTTINGHAM HISTOLOGIC GRADE 1 (WELL- DIFFERENTIATED). (SEE COMMENT 1) AT 6 O'CLOCK INVASIVE CARCINOMA MEASURES 1.5 X 0.4 CM IN CONTIGUOUS SECTIONS/SLICES. INVASIVE CARCINOMA IS PRESENT O.6 CM FROM CLOSEST INFERIOR MARGIN. FOCAL DUCTAL CARCINOMA IN SITU (DCIS), LOW GRADE, SOLID PATTERN. AT 2 O'CLOCK INVASIVE CARCINOMA MEASURES 3.5 X 3.0 CM IN CONTIGUOUS SECTIONS/SLICES. MARGINS ARE WIDELY FREE, PRESENT AT LEAST 1.0 CM FROM CLOSEST SUPERIOR MARGIN. FOCAL DUCTAL CARCINOMA IN SITU (DCIS), LOW GRADE, SOLID AND CRIBRIFORM PATTERNS. Associated fibroadenoma. Atypical lobular hyperplasia, atypical ductal hyperplasia. Secretory changes. OBuiastNo S 85&0 056.9 Reactive changes consistent with previous biopsy site. S:t. Dense fibrosis consistent with capsule.. 9o 81sl13 Microcalcifications present in association with invasive and in situ carcinoma, and with benign breast tissue. Nipple and skin, no tumor present. Skeletal muscle, no tumor present.. Intact breast implant, gross examination only.. (B) LEFT AXILLARY SENTINEL LYMPH NODE #1, EXCISIONAL BIOPSY: MICROMETASTASIS PRESENT IN ONE OF ONE LYMPH NODE. (SEE COMMENT 2) TUMOR CELLS ARE HIGHLIGHTED BY CYTOKERATIN IMMUNOSTAIN AND ARE PRESENT WITHIN AN AREA MEASURING 0.75 X 0.1 MM IN LARGEST SINGLE SLIDE DIMENSION (C) LEFT AXILLARY SENTINEL LYMPH NODE #2, EXCISIONAL BIOPSY:  SINGLE CYTOKERATIN POSITIVE ISOLATED TUMOR CELL PRESENT IN ONE OF ONE LYMPH NODE, MEASURES 0.01 MM IN GREATEST SINGLE SLIDE DIMENSION. (SEE COMMENT 3) (D) LEFT AXILLARY SENTINEL LYMPH NODE #3, EXCISIONAL BIOPSY: Fibroadipose tissue, no lymphoid tissue identified. Immunohistochemical stain for cytokeratin is negative. COMMENT 1) Immunohistochemical stains for biologic markers are pending. 2) In specimen B, the frozen sections are reviewed but the tumor cells are not evident. In H&E stained permanent sections, the. Iargest group of tumor cells can be identified but the tumor cells are bland and well differentiated. The tumor cells are best seen on immunostained slides and are present in four areas in the lymph node sections. The majority of the tumor cells are clustered within a 0.75 x 0.1 mm area. In addition, isolated tumor cells, singly or in pair, are present in three other regions of the lymph node sections. 3) In specimen C, tumor cells are not evident in the frozen and permanent H&E sections. GROSSDESCRIPTION (A) LEFT BREAST, SHORT SUPERIOR, LONG LATERAL - A 16.0 x 15.0 x 7.0 cm skin sparing total mastectomy specimen that is oriented by the surgeon with a short stitch designating superior and a long stitch designating lateral. The specimen is partly surfaced by a 4.5 x 3.5 cm ovoid portion of pale tan wrinkled skin. Located on the surface of the skin is an everted nipple surrounded by a rim of areola that measure 1.2 and 3.5 cm in diameter, respectively. The specimen is serially sectioned from. medial to lateral into eleven slices. The nipple is located in slice #5. In slices #2 through #10 there is a 12.0 x 12.0 x 2.7 cm breast. implant and cavity lined by a pink-white smooth, glistening, fibrous capsular tissue. The specimen contains an intact brand breast implant filled with a translucent viscous material. Identifying information is as follows: The breast implant measures 12.0 x 12.0 x 2.7 cm and is for gross only. Radiographs are taken of the specimen and display at the 6 o'clock position, within slices #5 and #6, a 1.5 x 1.0 x 0.5 cm firm, gray-white mass that grossly comes to within 0.6 cm from the anterior inferior margin, 3.5 cm from the deep margin, 3.5 cm from the nipple and abuts the implant capsule. There is a metal biopsy clip located in this mass in slice #5. At the 2 o'clock position, in slices #8 through #10, there is a 3.5 x 3.0 x 1.3 cm firm gray-white mass that grossly comes to within 3.0 cm from the deep margin, 1.0 cm from the anterior superior margin, 2.5 cm from the anterior inferior margin, and abuts the implant capsule. There is a metal biopsy clip located in slice #9 in this mass..
+
+--- Page 2 ---
+Remaining cut surfaces are 60% yellow glistening adipose tissue and 40% gray-white fibrous tissue. Some tissue has been given to tumor bank for research purposes. INK CODE: Blue - superior; orange - inferior; black - deep. SECTiON CODE: A1, A2, nipple from slice #5; A3, A4, 6 o'clock mass to inferior margin from slice #5; A5, slice #4, capsule and inferior margin, medial to 6 o'clock mass; A6, mass slice #6; A7, slice #7, lateral to 6 o'clock mass; A8, slice #7,. lateral to 2 o'clock mass; A9, 2 o'clock mass, slice #8; A10, 2 o'clock mass, slice #9; A11, 2 o'clock mass in area of clip, slice #9;. A12, 2 o'clock mass with superior margin, slice #9; A13, deep margin from slice #9; A14, 2 o'clock mass, slice #10; A15, representative sections from slice #11 (lateral margin), perpendicularlv sectioned and adjacent to 2 o'clock mass; A16, upper inner quadrant from slice #3; A17, upper inner quadrant from slice #4.. *IOA/DX: MARGINS ARE FREE GROSSLY/RADIOLOGIC. (B) LEFT AXILLARY SENTINEL LYMPH NODE #1, BLUE, IN VIVO 65, EX VIVO 117 - A 1.1 x 0.7 x 0.4 cm lymph node. SECTION CODE: B, one lymph node carialh, sectioned for frozen section diagnosis. *FS/DX: NO TUMOR PRESENT. (C) LEFT AXILLARY SENTiNEL LYMPH NODE #2, BLUE, IN VIVO 65, EX VlVO 27 - A 1.1 x 0.7 x 0.4 cm lymph node SECTiON CODE: C, one possible lymph node serially sectioned for frozen section diagnosis. *FS/DX: NO TUMOR PRESENT. (D) LEFT AXILLARY SENTINEL LYMPH NODE #3, BLUE, IN VlVO 65, EX VIVO 24 - A 2.0 x 1.5 x 0.5 cm portion of fibroadipose tissue. The tissue is dissected; however, a definite lymph node is not grossly identified. Cut surfaces are composed of unremarkable fibroadipose tissue. SECTION CODE: D, entire specimen. *IOA/DX: NO GROSSLY IDENTIFIED LYMPH NODE. DEFER TO PERMANENT. CLINICAL HISTORY Left breast cancer. SNOMED CODES T-04050, M-Y2003 "Some tests reported here may have been developed and performance characteristics determined by. These tests have r speciflcally cleared or approved by the U.S. Food and Drug Administration.'. Start of ADDENDUM
+
+--- Page 3 ---
+ADDENDUM COMMENT This report is issued to give Immunohistochemistry results. Immunohistochemical staining is performed in our lab on a representative paraffin-embedded section of INVASIVE LOBULAR CARCINOMA, left breast, block A4, 6 o'clock. MARKER Clone/Vendor RESULTS STAINING SCORE Estrogen Receptor 6F11-! Positive .95 %  Strong Progesterone Receptor PgR1294( )  Positive 95 %  Strong Ki-67 MIB1( ) Low 5 % N/A HER2 overexpression AB8( ) Negative N/A 1+ This report is issued to give Immunohistochemistry results. Immunohistochemical staining is performed in our lab on a representative paraffin-embedded section of INVASIVE LOBULAR CARCINOMA, left breast, block A11, 2 o'clock. MARKER Clone/Vendor RESULTS STAINING SCORE Estrogen Receptor 6F11. Positive >95 % Strong Progesterone Receptor PgR1294( )  Positive >95 %  Strong Ki-67 MIB1( Low 5 % N/A HER2 overexpression AB8 1  Negative N/A 1+ COMMENT Due to the above HER2 immunohistochemical staining result, gene copy level (HER2: CEP17 signal ratio) will be evaluated by. FISH and a separate report will be issued. FOOTNOTE  Breast specimens used for determining prognostic / predictive markers are fixed in formalin for 6-48 hours.. For ER & PR: Positive 10 - 100% Low Positive 1-9% For Ki-67 Low Positive <17% Moderate Positive17-35% High Positive >35% For Her 2: Positive cases are those with uniform, intense and complete membrane staining in greater than 30% of invasive tumor cells (Score 3+). Negative cases. are defined as those with no staining (Score 0) or weak, incomplete membrane staining in any proportion of cells (Score 1+). Equivocal or indeterminate cases are  those with strong staining in less than or equal to 30% of cells, or complete membrane staining that is either non-uniform or weak in intensity, but with obvious. circumferential distribution in at least 10% of tumor cells (Score +2) Reference Wolff AC, Hammond EH, Swartz JN et al. American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for. Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer. Arch Pathol Lab Med. 2007;131:18-43.
+
+--- Page 4 ---
+Start ot ADDENDUM#2
+
+--- Page 5 ---
+ADDENDUM For FISH results, please see ---END OF REPORT----
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diff --git a/output/text/659c30e0-1a52-49d6-9872-693077b62741.txt b/output/text/659c30e0-1a52-49d6-9872-693077b62741.txt
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+P.88 Anonymous No.:. Ago Gender: F Race: White CLINICAL HISTORYS Large papillary tumor in medial breast, core biopsy positive, malignant calcifications lateral breast undlagnosed. Lmp: Postmenopausal. PRE-OP DIAGNO$IS: Right breast cancer. 10s-0 -3 POSt-OP DIAgnOsiS: Same. CaVnioma, nifit+nntwg cuchl, No3 85Oof3 PROCEDURE: Right total mastectomy. sentinel nodc. Site. brsst, Nos c5o.9 3/13|1 w FINAL DIAGNOSIS PART 1. SENTINEL NODE, RIGHT BREAST, BIOPSY ONE LYMPH NODE. NEGATIVE ROR METASTATIC CARCINOMA (0/1) PARt 2: BREASt. RIGHT. RIChT TOTAL, mASTECTOMY A. INFILTRATING DUCTAL.CARCINOMA, WITH PAPILLARY FEATURES AND NECROSIS.E B. NOTTINGHAM SCORE 8/9, GRADE 3 (TUBULES-2, NUCLEI-3, MITOSES-3). c.  NEOPLASM MEASURES 5.5 CM ON GROSS EXAM. D. MARGINS OF RESECTION FREE OF NEOPLASM, CLOSEST MARGIN IS POSTERIOR AT O.7 CM. E.  NO LYMPHOVASCULAR INVASION IDENTIFIED. F. NO EXTENSION INTO SKIN. G PATHOLOGIC STAGE: pT3,pN0, pMX H. ER NEGATIVE. PR NEGATIVE, HER-2/NEU POSITIVE, SCORE: 3+. DUCTAL CARCINOMA IN-SITU, CRIBRIFORM TYPE. NUCLEAR GRADE 3 WITH COMEDO NECROSIS AI CALCIFICATIONS. J.  IN SITU CARCINOMA IS IDENTIFIED OUTSIDE OF INVASIVE COMPONEN'T IN ONE OF SIXTEEN SECTIONS K.  mARGINS OF RESECTION FREE OF IN SITU NEOPLASM. CLOSEST POSTERIOR AT O.7 CM [. UNREMARKABLE NIPPLE.  ATYPICAL OUCTAL HYPERPLASIA WITH ASSOCIATED CALCIFICATIONS ((LATERAL/OUTER QUADRANTS) N.  RADIAL SCAR (LOWER INNER QUADRANT). 0.  SMALL iNTRADUCTAL PAPILLOMAS (LOWER INNER QUADRANT). p. FIBROCYSTIC CHANGES WITH DUCTAL EPITHELIAL HYPERPLA$IA. SCLEROSING ADENOSIS AND CALCIFICATIONS. UUID: B8664381-386A-44A2-AC3B-D69A4980A8EA Redacted TcgA-Bh-A0ee-01a-Pr 13/
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diff --git a/output/text/65e3d79c-f6a6-4932-a50a-e0edd3017046.txt b/output/text/65e3d79c-f6a6-4932-a50a-e0edd3017046.txt
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index 0000000000000000000000000000000000000000..30dd21d854ed592dc59d864a4dace9247535eead
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+--- Page 1 ---
+Clinical Diagnosis & History .hepatitis. Rectosigmoid cancer queation. Specimens Submitted 1 colon, Sigmoid and upper rectum resection 2:1iver,leftbiopsy 3:Proximal margin; exciaion 4:Distal margin excision DIAGNOSIS: COLON, SIGMOID AND OPPER RECTUM RESECTION -INVASIVE ADENOCARCINOMA, MODERATELY DIFFERRNTIATED. -TOMOR LOCATION:RECTOSIGMOID TOMOR SIZELENGTH IS 3.5 CM,WIDTH IS 3.2 CMMAXIMAL THICKNESS IS 0.3CM -GROSS CONFIGURATION:POLYPOID PREEXISTING POLYP (AT THE SITE OP THE CARCINOMA:IDENTIFIED TUBULOVILLOUS ADENOMA. -TUMOR INVASION: INVASION INTO SUSMUCOSA. -SEROSAL INVOLVEMENT: NOT IDENTIFIED. -VASCULAR INVASION: SUSPECTED -PERINEURAL INVASION: NOT IDENTIFIED. -SURGICAL MARGINS: FREE OF TUMOR 4.O CM BETWEEN DEEPEST TUMOR PORTION AND DEEP (RADIAL SOFT TISSUE) MARGIN. -POLYPS AWAY FROM THE CARCINOMANOT IDENTIFID NON-NEOPLASTIC BOWEL: UNREMARKABLE. pT2 -THE PATHOLOGIC STAGE IS AJCC 2NUMBEREXAMINED52 -LYMPH NODES:NUMBER WITH METAS pN1 -THE PATHOLOGIC STAGE IS AJCC NOTE: IMMUNOHISTOCHEMICAL STAINS FOR THE TESTED DNA MISMATCH REPAIR PROTEINS MLH1PMS2MSH2AND MSH6) SHOW THAT EXPRESSION OF ALL PROTEINS IS RETAINED IN THE TUMOR CELLS. LIVERLEFTBIOPSY 2. -SUBCAPSULAR HEPATIC PARENCHYMA WITH NON-SPECIPIC REACTIVE CHANGES. NOTP: TRICHROME AND RETICULIN SPECIAL STAINS DO NOT SHOW INCREASED FIBROSIS. AN IRON STAIN SHOWS NO STAINABLE IRON. THERE IS NO EVIDENCE OF AUTOIMMUNE HEPATITIS IN THIS MATERIAL. PART 2 WAS REVIEWED IN CONSULTATION Continued on next page **
+
+--- Page 2 ---
+Page 20f4 3. COLONPROXIMAL MARGIN;BXCISION -BENIGN SEGMENT OF COLON. RECTUM, DISTAL MARGINEXCISION BENIGN SEGMENT OF RECTOM I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED DPON MY PERSONAL EXAMINATION OF THE SLIDES AND/OR OTHER MATERIAL).AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Special Studies: Special Stain Comment Result TRICHROME IRON RETIC Gros 1. The specimen is received fresh and is labeled "sigmoid and upper rectum, stitch marks proximalIt consists of a rectosigmoid colon that measures 16.5cm. The serosal surface is smooth. The radial resection margin is inked black and the specimen is opened to reveal a polypoid tumor that is located 5.0 cm from the distal margin. The tumor measures 3.5 cm in length and 3.2 cm in width. Serial sectioning reveals tumor invasion into tbe muscularis propria to a depth of 0.3 cm, which is 4.0 cm from the closest radial margin. A tattoo site is identificd distal to the tumox. The specimen is Pericolic and peri-rectal adipose submitted fox lymph node disseotion. tissue is thoroughly examined for lymph nodes and all possible nodes are submitted. Representative sections are submitted. Tps is submitted. Summary of sections: PM --proximal margin DM distal margin RM -- radial margin -tumor polyp and tatoo aite -uninvolved mucosa LNS -- lymph nodes 2 The opecimen is xeceived in formalin, labeled Left liver biopsy and consists of two fragments of focally hemorrhagic tan-brown soft tissue *Continued on next page *
+
+--- Page 3 ---
+Page 30f4 measuring 1.0x0.7x0.2 and 0.7x0.6x0.2cmwhich are submitted entirely. Summary of sections -undesignated specimen is received in formalin, labeled "Proximal margin and consiats of a silver metal anastomotic pin measuring 5.8 x 2.8 x 1.5 cm.At the center of the pin, a blue plastic piece is noted. A ring of grossly cm unremarkable pink tan soft tiseue is attached measuring l.5 x 1.3 x 0.9 Blue suture material is attached. The sutures are removed and the soft tisoue is entirely submitted. Sunmary of sections: U--undesignated 4) The specimen ia received in formalin, labeled pistal margin and conaists of a ring of glistening focally hemorrhagic pink tan soft tissue measuxing 1.7 x 1.7 x 0.9 cm Multiple sutures and stapies are attached.The sutures and staples are removed and the soft tissue is entirely submitted. Summary of sections U--undesignated Summary of Sections Part l colon, Sigmoid and upper rectum resection Sect.Site PCa Block 12 BLN 6 DM LN 9 1 PM 2 1 RM 5 HP 1 Part2 liver,left;biopey Sect.Site PCs Block u 1 1 Part3 Proximal margin;excision PCs Block Sect.site 1 Continued on next page 
+
+--- Page 4 ---
+Page 4 of4 Part 4: Distal margin; excision Sect.site PCB Block End of Keport *
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diff --git a/output/text/65ea40ad-aea8-4487-821d-dc8078aca086.txt b/output/text/65ea40ad-aea8-4487-821d-dc8078aca086.txt
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index 0000000000000000000000000000000000000000..8d531383d2f2667fa54ea1f337e2dda785ae3e92
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+
+--- Page 1 ---
+Path (First Tumor) Tumor Site: Descending Colon Date of Cancer Sample Procurement: Histology: Adenocarcinoma 3 Description of other histology: Grade: Moderately Differentiated 6 Yes r No r Yes r Unknown Mucinous: (Focal)  Yes 6 No ( Yes r Unknown Signet Ring Feature: (Focal) Histologic Heterogeneity: C No  Yes C Unknown Host Response:. None  None C Yes C Unknown Crohn's like reaction C No C Yes Plasma cell rich stroma C Unknown  Expansile Growth Pattern:  Expansile  Invasive C Unknown and Invasive. Inflammatory Bowel Disease 6 No C Yes C Unknown 6 No ( Yes Angiolymphatic Invasion: C Unknown Mutator Phenotype: r No  Yes r Unknown Number of Slides  Yes Garland Necrosis present: C No  Yes C Unknown (Focal) TIL Cells / HPF [3.4 Pathologist Comment: /co-0-3 acLnocaicmma, NOs 814of3 Sitx : descndiig color c18.b UUID:0A659279-BA92-44AF-9E93-80457ADEC729 TCGA-DM-A28M-01A-PR Redacted hr 3/7|n
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diff --git a/output/text/66209c3d-095b-4ab6-ae7e-ead438c6f619.txt b/output/text/66209c3d-095b-4ab6-ae7e-ead438c6f619.txt
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index 0000000000000000000000000000000000000000..c5e0ea95341dbeb1256d461fb0f4f27e264edba0
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+--- Page 1 ---
+/es-0-3 Cavcinomx,in fi1trtng ouct N0s 85v6f3 UUID:5E997487-9A03-4723-81E6-FA08557D8FDF Redacted Site: brast. TCGA-D8-A27R-01A-PR NOS C50.9 ps 5/9/n page 1 / 2 original Examination: Histopathological examination Internal invoice No. Value of diagnostic procedure. Examination No. Patient: xxx PESEL: XXX Age: Gender: F  Material: Total organ resection -- right breast with axillary tissues Unit in charge:  Physician in charge: Material collected on: Material received on: Expected time of examination: up to 8 working days 579 Clinical diagnosis: Cancer of the right breast ? Examination performed on Macroscopic description:  Right breast szed 14.4 x 11.2 x 4.2 cm removed along with axillary tissues sized 8 x 5 x 2 cm and a skin flap of 12,2 x 8.8 cm. Weight 330 g. Tumour sized 3.2 x 2.3 x 2.6 cm found on the boundary of upper quadrants, located 1.6 cm from the upper boundary, 0.5 cm from the base and 1.2 cm from the skin.. Microscopic description: Carcinoma ductale invasivum - NHG3 (3 + 3 + 3 / 2 0 mitoses/10 HPF - visual area: 0.55mm).  Numerous foci of carcinoma ductale in situ Dcis found within the tumour (solid type with high nuclear atypia and comedo necrosis with calcinations, 20% of the tumour volume).  Invasio carcinomatosa vasovum massiva. Emboliae carcinomatosae mamillae. Glandular texture showing parenchyma of normal structure. In situ lesions removed by 0.1 cm from the base AXILLARY LYMPH NODES:  Metastases carcinomatosae in lymphonodis (No Xi/xI). Infitratio telae perinodalis.. Emboliae carcinomatosae vasorum. Test result: Incl. Examination  Metastases carcinomatosae in lymphonodis axillae. Cancer metastases in axillary lymph nodes. (No xi/xt) (NHG3, pT2, pN3a). Invasio carcinomatosa vasorum massiva. Massive vascular invasion.. Compliance validated by: Examination performed on'
+
+--- Page 2 ---
+page 2 / 2 Examination: Histopathological examination. Examination No.: peseL: XXx Gender: F Patient: xxx Examination performed on Results of immunohistochemical examination:. Estrogen receptors found in over 75% of neoplastic cell nuclei. Progesterone receptors found in 10-75% neoplastic cel! nuclei. HER2 protein stained with Ventana's Pathway HER-2/neu (4B5) Rabbit Monoclonal Antibody. Score=2+, FISH verification recommended. dr Compliance validated bye
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diff --git a/output/text/662e69fa-6a96-4065-a8ce-200cbeca4a09.txt b/output/text/662e69fa-6a96-4065-a8ce-200cbeca4a09.txt
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index 0000000000000000000000000000000000000000..9cd4ad2cb23e57467caee2019dea3fe56c950de4
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+
+--- Page 1 ---
+UUID:56301ED2-1A88-4D90-BD42-AC3790004913 TCGA-A7-A4SD-01A-PR Redacted Final Surgical Pathology Report Procedure: Diagnosis A. Sentinel lymph node #1, excision: No evidence of metastasis in 3 lymph nodes (0/3). B. Sentinel lymph node #2, excision: No evidence of metastasis in 3 lymph nodes (0/3). C. Right breast, mastectomy:. Infiltrating ductal carcinoma, grade 3, 4.3 cm greatest dimension, surgical margins negative but close (0.4 cm, deep). Microscopic Description:. Microscopic examination performed. A. B. sections of sentinel lymph nodes 1 and 2 demonstrate no evidence in 3 lymph nodes in each specimen. The lymph nodes were examined by multilevel sectioning with H&E staining as well as by histochemistry for pankeratin. C. Invasive Carcinoma: present Histologic type:  infiltrating ductal cancer Histologic grade: Overall grade: 3 Architectural score:. Nuclear score: 3 Mitotic score: Greatest dimension (pT): 4.3 cm, pT2 Specimen margins:  negative, 0.4 cm to deep margin Vessel invasion: not identified Calcification:  not identified Ductal carcinoma in situ: not identified )cs-0~3 Specimen Sentinel node #1 C arcinoma, nfAtnuHng cuct, noS B. Sentinel node #2 8s 00/3 C. Right mastectomy, arrow points up Sif: buustNos C5D.9 Clinical Information. Right breast cancer 10/27/1)- Intraoperative Consultation AFsi-Ars3: Sentinel lymph node #1, excision - No metastasis identified in 3 nodes. BFs1-brs3: Sentinel lymph node #2, excision - No metastasis identified in 3 nodes. Gross Description A.  Container a is labeled with the patient's name, medical record number and "sentinel node". The specimen container holds 3 lymph nodes ranging in size from 1.5 x 1 x 1.5 cm to 0.6 x 0.5 x 0.4 cm. AFs 1,
+
+--- Page 2 ---
+ Container B. is labeled with the patient's name, medical record number and "palpable nodule right axilla". Per Dr. this should be. regarded as such libido for to. The specimen container holds 3 separate lymph nodes. Each lymph node is bisected and submitted in one block, C. Received fresh and subsequently placed in formalin at labeled "right mastectomy" is a 27.0 cm (superior to inferior) by 26.0 cm (medial to lateral) by 6.5 cm (anterior to posterior) diffusely cauterized soft, lobulated tan-white-gold portion of fibroadipose tissue in keeping with breast. A 23.5 x 10.0 cm wrinkled brown skin ellipse with a central, 1.1 x 1.1 x 0.7 cm nipple is present along the anterior aspect.  A palpable nodular mass corresponds to the lower inner quadrant and the anteroinferior surface is inked orange. The intact deep margin is inked blue and the specimen is sectioned. The after mentioned palpable mass is well-circumscribed glistening tan-white and rubbery, measuring 4.3 cm (medial to lateral) by 3.8 cm (anterior to posterior) by 3.1 cm (superior to inferior).  The tumor extends to within 0.4 cm of the inked deep margin and 1 cm of the. anteroinferior inked surface.  Several cylindrical firm tan-white structures are associated with the lesion. A portion of the lesion and a portion of normal parenchyma are submitted for tissue procurement as requested.  The remaining soft, lobulated tan gold adipose tissue with a scant amount of interspersed delicate tan-white fibrous tissue.. No additional mass lesion or abnormality is identified grossly. Rs 12 Summary: 1 through 3 - tumor to inked deep margin, 4 and 5 - tumor to inked anteroinferior margin, 6 - tumor to normal parenchyma, 7 - random. quadrant, 10  - lower outer quadrant, 11 - junction of the 4 quadrants, 12 - nipple
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diff --git a/output/text/6672baa3-5bab-4fb3-a5e3-5d6b1aeb16a8.txt b/output/text/6672baa3-5bab-4fb3-a5e3-5d6b1aeb16a8.txt
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+I ed - Carciiomu,cluct, N0s 85oo13 Site &ed : bresot, N0s C5O.9 Patient 1/17/4 h Surgica! Surg Path CLINICAL HISTORY: Breast cancer. GROSS EXAMINATION: A. "Breast tissue long stitch lateral, short stitch superior", in formalin. Tissue has been sent for ER/pR studies. A 5 x 8.5 x 5 cm fragment of breast tissue and ellipse of skin measuring 5 x 1 cm. The specimen is oriented such that a long surgical suture is present at the lateral side of breast tissue and a short surgical suture demarcates the superior portion of the specimen. The external surface of the specimen is inked in blue.. The specimen has been previously sectioned revealing a densely fibrotic area of tissue with a central reddish-brown nodule measuring 1.5 x 0.8 x 0.6 cm. Th reddish nodule is 0.1 cm from the closest surgical margin.. Block Summary: Al- representative sections of skin. A2-Al5- sections of biopsy cavity and nodule.. A16-A20- representative sections of remaining breast tissue.. B. "Apex axillary nodes", fresh.. A 0.3 x 0.2 x 0.2 cm fragment of reddish-tan tissue submitted in toto in Block B1. C. "Axillary dissection", fresh. A 6 x 6 x 2 cm aggregate of fibroadipose. tissue. The specimen is oriented.. UUID: 5F08632D-BC1D-4414-80C1-75F67F3A07AF Block Summary: TCGA-B6-A0RN-01A-PR Redacted C1-C5- lymph node candidates. C6-c10- remaining fibroadipose tissue. MICROSCOPIC EXAMINATION: The tumor resemble that seen in the previous needle biopsies .-.. Most of the tumor consists of nests and cords of relatively large atypical cells with round to oval vesicular nuclei and inconspicuous nucleoli and vaculoated cytoplasm. Although most of the tumor consists of solid nests and strands, a few tubules are seen. There is a cribriform intraductal component. Unequivocal vascular invasion is not identified. There is virtually no inflammatory response. Microcalcifications are seen within benign lobules. DIAGNOSIS: A. "BREAST TISSUE, LONG STITCH LATERAL, SHORT STITCH SUPERIOR":S BREAST WITH INFILTRATING DUCTAL CARCINOMA, 1.5 CM IN MAXIMUM DIMENTSION, NSABP HISTOLOGIC GRADE 2, NUCLEAR GRADE MODERATELY DIEFERENTIATED.S INVASIVE CARCINOMA IS PRESENT IN THE INKED SURGICAL MARGIN IN BLOCKS A5 AND Al1. NO VASCULAR INVASION IS IDENTIFIED. B. "APEX AXILLARY NODES": ONE LYMPH NODE, NO TUMOR SEEN. C. "AXILLARY DISSECTION": EIGHTEEN LYMPH NODES, NO TUMOR SEEN. 1 of2
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diff --git a/output/text/668c39b3-1a2a-4f84-a07b-2b2a872c72e7.txt b/output/text/668c39b3-1a2a-4f84-a07b-2b2a872c72e7.txt
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index 0000000000000000000000000000000000000000..596da3ca4b928c381e6fabbfe7d7101a4fc8e16b
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+page 1 / 1 Department of Cancer Pathology copy No. 5 Date: Examination: Histopathological examination Examination No.: Patient: XXX PESEL: XXX Age: Gender: Material: 1. Total organ resection - sigmoid colon. Unit in charge: Physician in charge: Material collected on: Material received on: Expected time of examination: Clinical diagnosis: Tumour of the sigmoid colon tumour.  Examination performed on: Macroscopic description: A 18 cm length of the large intestine with a piece of mesentery and fat tissue sized 23 x 10.5 x 3 cm. A cauliflower- shaped, partially ulcerous tumour sized 7.5 x 5.5 x 3 cm found in the mucosa sized 4.5 x 4 x 1.3 cm. The lesion surrounds 1o0% of the intestine circumference and narrows its lumen, is located 4.4 cm from one of the incision lines and 5.9 cm from the other one. The lesion infiltrates macroscopically the whole thickness of the intestine wall and periintestinal tissues. Microscopic description: Adenocarcinoma tubulopapillare (G2). Infiltratio carcinomatosa tunicae muscularis propriae et serosae coli et telae adiposae mesenterii pericolicae. Of note is a massive inflammatory invasion, mainly plasmocytic, in the tumour in its surroundings. Intestine ends free of neoplastic lesions.. Minimum side margin is 0.1 cm. Intestine ends free of neoplastic lesions. Metastases carcinomatosae in Iymphonodis (No Ill/xxxiv). Infiltratio carcinomatosa capsulae lymphonodorum et telae adiposae perinodalis.. Histopathological diagnosis: Adenocarcinoma tubulopapillare coli. Tubulopapillar adenocarcinoma of the colon. Metastases carcinomatosae in Iymphonodis. Cancer metastases in the lymph nodes. (No III/xxxiv). (p2, Dukes C, Astler-Coller C2, pT4a, pNI). Compliance validated by! CONTACT YOUR DOCTOR WITH THIS REPORT!
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diff --git a/output/text/6697411a-771d-4f10-be63-494f555158c3.txt b/output/text/6697411a-771d-4f10-be63-494f555158c3.txt
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+Diagnosis: This is an invasive, poorly differentiated colon carcinoma (sigmoid colon carcinoma) G3 with penetration of all parietal layers (pT3) and vascular infiltration (L1, V1), - with regard to the resection margins in the mucosa region and in the deep circumferential resection margin, these are free resection margins, Tumor classification: ICDO-DA M8140/3, G3 pT3 L1, V1, pN1 (2 of 13 + 1), locally R0
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diff --git a/output/text/669c83a9-3192-43a1-bfb3-e4e002256606.txt b/output/text/669c83a9-3192-43a1-bfb3-e4e002256606.txt
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+1cs-0-3 Adenocerci omo, infiltrahng duf 8500/3 Site: bruast, Nos C50.9 1a7h SurgiCAl repORt Name Pathology Numbe! Sex: F Date Coliected: DOB: Date Received: Location: M.R. Number Doctor: Account Number pre-OpErative Diagnosis RIGHT BREAST CAE pOST-OPERATIVe DIAGnOSiS Right Breast CA PROCEDURe Right Breast LumpeCTomy With SEntineL Lymph nODe BiOpsy. f.S., POSsiBle AxIllARy Dissection, pOssIBLe CED INSERTION TISSUES A. LYMPH NODE (S) - RIGHT SENTINEL LYMPH NODE #1 **FS** B. LYMPH NODE (S) - RIGHT SENTiNEL LYMPH NODE #2 **FS** C. LymPH NODe (S) - RigHT SENTINEL LYmPH NODE #3 **FS** D. LYMPH NODE (S) - RIGHT SENTINEL LYmPH NODE #4 E. AXILLARY - CONTENTS F. BREAST EXCISION,NEEDLE LOC,SIMPLE,MARGINS,ETC. - RIGHT BREAST LUMPECTOMy G. MARGINS - ADDITIONAL LATERAL ADDENDUM EstrOgen And PrOgesterOne ReceptOr ResuLts: Estrogen rReceptors -- UUID:C58701EF-98C4-448E-978C-B39D125CC7E8 NEGATive (0%) in THe mALiGnANT CeLLS. Redacted Progesterone receptors -- NEGATiVe (0%) in THe MALIGnAnT CeLLS. Comment: immunohistochemlcal (iHC) stalns for Estrogan Receptors (ER) and Progesterone. Receptors (PR) display an appropriate staining pattern on control tissue.s Revlewed and electronically signed out by:. FS DIAGNOSiS A. Right Sentinel. Lymph nODe #1, F.S. - ONE NEGATIVE LYMPH NODE (0/1). B. Right sentInel Lymph nODe #2, f.s. - ONe NeGATive Lymph NODe (0/1). Patlent Nams Pathology Number: SURGICAL REPORT Page 1 of 4
+
+--- Page 2 ---
+Patlent Nam Pathology Number: C. Right Sentinel Lymph nODe, #3, f.s. - One positive lymph nOde (1M). F. Right breast lump (gross margins) -- 4.7 Cm. tumOr mAss AnD fOcally Involving Lateral SurgiCal margin. (reported to suroeon: Diagnosed by: FINAL DIAGNOSIS A.  RIght SEnTinel Lymph nODe #1  Lymph node, reactive. B. Right sentinel Lymph nODe #2 - Lymph node, reactive. C. Right sentinel Lymph node, #3 -- Metastatic PooRly DifferentIateD Ductal AdenocArcinoma in the Lymph node. The metAStAtic tumOR inVOLVes ApprOximAteLy 40% The siZe Of the Of the node and best seen in the cryostat sections with no extrA- CAPSULAR EXTENSION. D. RIght senTInel Lymph nOde #4 - Lymph node, one reactive. E. RIght AxIlLary ConTeNTs - Lymph nodes, total Of fifteen reactive lymph nodes. F. Right breast lump - Breast tissue Displaying poorLy DifterentiateD Ductal ADenocArcinomA Of The breast, high graDe (2+3+3), 47 mm. in greatest Dimension. THe nearest margin Is the Lateral margin ApproxImately 1 mM. All Other margins are free. Associated fibroadenoma of the breast. G. ADDiTiOnal LAteral mArgin - FIBrOaDipOse And Breast Tissue, NO PathOlOgiC Change. PTNm CLASsiFICAITON: t2 N1 mx, stAge iib, ductal. ADenocarcinoma Of breast, G3. pQRi cATegORy II: 3260F. Dlagnosed by: Revlewed and electronically slgned out by. COMMENT Patlant Nams Pathology Number. SURGICAL REPORT Page 2 of 4
+
+--- Page 3 ---
+Patient Namt Pathology Numbe This case is discussed with r. I by Dr. Breast cancer prognostic profile will be oerformed and reported separateiy. GROSS DESCRIPTION  The specimen is received in seven separate conta'rers labeler through E. signated A A The container is received fresh unfixed labeled "right sentinei lymph node #1 for frozen section" and consists of an ovoid mass of apparent fatty material measuring 1.5 x 1 x 0.6 cm. Sectioning reveals a 0.5 cm. pink-tan firm nodule. Touch prep and frozen section are obtained by Dr. The entire specimen including frozen section is submitted In two blocks. B. The container is received fresh unfixed labeled *right sentinel lymph node #2 for frozen section" and consists of an irregular mass of apparent fat which is 1 x 0.6 x 0.4 cm in greatest overall dimenslon. Sectioning reveals a 0.8 cm. purple-tan flrm noduie. Touch prep and frozen section are obtalned by Dr.  The entlre specimen Including trozen sectlon Is submltted in two blocks. C. The contalner Is received fresh unfixed labeled *rlght sentinel lymph node #3 for frozen section" and conslsts of an irregular mass of apparent fat which is 1 x 0.4 x 0.4 cm. In greatest overall dimension. Sectioning reveals a pink-tan nodule 0.5 cm. in greatest dimension. Touch prep and frozen sectlon are obtained by Dr.. The entire specimen including frozen section is. subrnitted in two blocks. D. The container is received fresh unfixed labeled "right sentinel iymph node #4 for frozen section" and consists of an irregular mass of apparent fat which is 0.6 x 0.4 x 0.3 cm. The specimen is deferred for permanent. The entire specimen is submitted in one block. E. The container is received fresh unfixed labeled "right axiltary contents" and consists of an irregular mass of fat which is 4.5 x 4 x 3 cm. In greatest overall dimension. Sectioning reveals purple-tan nodules varying up to 2 cm. in greatest dimension. The specimen is submitted in four blocks. F. The contalner is received fresh unfixed labeled "right breast lump" and consists of a 57 gm. ovoid mass of apparent fatty and fibrous-encased tissue measuring 6.5 x 5 x 5 cm. in greatest overa!! dimenslon. Sectioning reveals a tumor mass which is 6 x 5 x 5 cm. in greatest overall dirmension. There are two short sutures indicating superior margin inked with red dye, inferior is inked yellow. There is a singie short suture Indicating anterior margin Inked with orange dye, deep is inked with black. There is a single long suture indicating lateral margin inked with blue dye, medial is inked green. Gross margins are observed by Dr.. The tumor mass grossty appears to be 0.6. away from the superior, 1 cm. away from the inferior, 1.5 cm. away from the anterior, 1 cm. away from the deep and grossly appears to Involved the lateral or less than 0.1 cm. from the lateral; is approximately O.4 cm. away from the medlal. The specimen is submitted in ten blocks. Key Note Block Summary: 1--- superior, 2--- inferior, 3-- anterior, 4 --deep, 5-- iateral, 6--- medial, 7 through 10---random.. G The container Is received fresh unfixed labeled *additional lateral margin" and consists of a 7 gm. irregular mass of apparent fatty tissue which is 3 x 2.5 x 2 cm. in greatest overall dimension. There is an attached suture indicating new lateral margin inked with biack dye. Serial sectloning reveals apparent fatty tissue. The entire speclmen is submltted as six blocks. Patlent Name Pathology Numbr SURGICAL REPORT Page 3 of 4
+
+--- Page 4 ---
+Patlent Namtd  Pathology Numba MICROSCOPIC EXAM  MiCROSCOpiC exAmINATION CONDUCTeD 8y PAThOLOQiST CONFIRMs FiNAL DIAGNOSIS. SPECIAL STAiNS PERFORMED: ER, PR, Har-2 (IHC) (speclmen F - 2) Patlent Namad Pathology Numbe SURGiCAL REPORT Page 4 of 4
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diff --git a/output/text/66e1574a-497e-401a-9ac3-890f508893c0.txt b/output/text/66e1574a-497e-401a-9ac3-890f508893c0.txt
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index 0000000000000000000000000000000000000000..c243879a78875fe35d4ab133fd6638a9276e1c78
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+FOR OFFI AL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: FMp/SSN: DOb/Age/Sex: (Age: )F Race: WHITE Taken: Location: Physician(s) : Received: Reported: **AMENDED** Jcs-0-3 Cacinona, nifI+natNg ductul, nos 85sof! SPECIMEN: Sit: bresot,N05 A: WIDE LOCAL EXCISION RIGHT BREAST B: SENT LN #1 C50.9 C: SENT LN #2 D: SENT LN #1 ( 1/4 E: SENT LN #2 ( F: NONSENT LN #3 FINAL DIAGNOSIS: A. BREAST, RIGHT,/ WIDE LOCAL EXCISION: INVASIVE DUCTAL CARCINOMA, MODERATELY DIFFERENTIATED (BLOOM-RICHARDSON: TUBULAR FORMATION-2, NUCLEI-2, MITOSES-2 = 6), 1.7 CM, NEGATIVE FOR LYMPHVASCULAR INVASION, MARGINS NEGATIVE. FIBROCYSTIC CHANGES TO INCLUDE CYSTS, FIBROSIS, APOCRINE METAPLASIA, AND DUCT ECTASIA. MULTIFOCAL FAT NECROSIS.  ER/PR IMMUNOSTAINS ARE STRONGLY POSITIVE - HER2-NEU OVEREXPRESSION BY FISH: NOT AMPLIFIED (1.2) B. LYMPH NODE, NON-SENTINAL #1, BIOPSY: TWO LYMPH NODES NEGATIVE FOR MALIGNANCY (O/2). C. LYMPH NODE, NON-SENTINAL #2, BIOPSY: TWO LYMPH NODES NEGATIVE FOR MALIGNANCY (O/2). D. LYMPH NODE, SENTINAL #1 BiopSy: NEGATIVE FOR MALIGNANCY BY IMMUNOHISTOCHEMICAL STAINS E. LYMPH NODE, SENTINAL #2 BIOPSY: NEGATIVE FOR MALIGNANCY BY IMMUNOHISTOCHEMICAL STAINS F. LYMPH NODE, NON-SENTINAL #3, BIOPSY: BENIGN ADIPOSE TISSUE, NO LYMPHOID TISSUE PRESENT. PATHOLOGIC STAGING :T1c NO MX COMMENT : UUID:4584899C-80E6-4AF4-8692-F7EE19D0467A0 CYTOKERATIN IS NEGATIVE IN SPECIMEN D AND E. TCGA-A2-A04N-01A-PR Redacted Page 1 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 2 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: FINAL DIAGNOSIS (continued): ** Report Electronically Signed Out. * CLINICAL DIAGNOSIS AND HISTORY:S -year-old white female with 2.5 cm right outer mid breast tumor. needle aspiration positive for atypical cells consistent with carcinoma. Fine FROZEN SECTION DIAGNOSIS: A: RIGHT BREAST - INFILTRATING DUCTAL CARCINOMA Results relayed to Dr. in person. GROSS DESCRIpTION: A. WIDE LOCAL EXCIsION RIGHT BREAST received fresh and consists of a piece of fatty tissue measuring 9.0 x 8.0 x 3.0 cm. The specimen is oriented with sutures by surgeon. Ink code: Red=medial lateral, blue-superior, green-inferior, yeliow-anterior, black-posterior. Sectioning reveals a firm, tan, well-circumscribed mass, 1.7 cm in greatest dimension in the mid portion of the specimen; the mass is located 0.8 cm from the deep margin. A frozen section is prepared (block Al). There is a second well-circumscribed, tan nodule, 0.7 cm in diameter, located 0.5 cm superior anterior to the main mass. Sections harvested for breast protocol include (1) mass, OcT embedded (2) mass, flash frozen, and (3) grossly normal breast from the medial end of the specimen, flash frozen (matching paraffin sections=Al and A2, respectively). Additional representative sections are submitted in sequential order from lateral to medial in cassettes A3 through A12. First mass in cassettes Al, A5, A6, A8, and the second mass in A7, A9, Al0, and All. l2cF. B. SENTINEL LYMPH NODE NUMBER ONE "NON-SENTINEL NODULE NUMBER ONE" received in formalin and consists of two irregular fragments of tan soft tissue with attached yellow adipose tissue measuring 2.0 and 1.7 cm in greatest dimension. The fragments are bisected and submitted in their entirety in two cassettes, one node per cassette. 2C4. C. SENTINEL LYMPH NODE NUMBER TWO "NON-SENTINEL NODE NUMBER TWO" reCeiVed in formalin and consists of two irregular fragments of yellow, lobular adipose tissue measuring 2.5 cm in greatest dimension each. The fragments are bisected and submitted in their entirety in two cassettes, one fragment per cassette. 2C4. Page 2 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 3 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION (cOntinued) : D.  SENTINEL LYMPH NODE NUMBER ONE received in formalin and consists of one ovoid fragment of tan, fibrous tissue with attached yellow adipose tissue measuring 2.5 cm in greatest dimension. The specimen is serially sectioned and submitted in its entirety in two cassettes. 2C4. E. SENTINEL LYMPH NODE NUMBER TWO of a fragment of tan soft tissue measuring 2.5 cm in greatest dimension. received in formalin and consists The specimen is trisected and submitted in its entirety in two cassettes. 2C3 F. NON-SENTINEL LYMPH NODE NUMBER THREE received in formalin and consists of one ovoid fragment of tan soft tissue with adherent yellow adipose tissue measuring 1.7 cm in greatest dimension. The specimen is bisected and submitted in its entirety in one cassette.. 1C2: Page 3 End of Report FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974E
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diff --git a/output/text/66ea58a3-ec43-44ae-96f3-6ff0416e3ced.txt b/output/text/66ea58a3-ec43-44ae-96f3-6ff0416e3ced.txt
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index 0000000000000000000000000000000000000000..10bde31a7e84cb4a61e6597de453a8d9d4513e76
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+UUID:007C609A-7874-4E39-BC4D-1EA81F4722EA 1c0-0-3 TCGA-AR-A0U1-01A-PR Redacted Carciomn vifji1fnstng oucti! Nos 85oof3 Site: Sresst, Nos C50.9 Breast, left, wide local excision: Invasive ductal carcinoma, Nottingham grade 3 (of 3), forming a 2.3 x. 2.2 x 2.0 cm mass (AJCCpT2). All surgical margins, including separately submitted inferior margin, are. negative for tumor. Lymph node, left breast intramammary, excision: Metastatic adenocarcinoma. no extranodal extension is identified. Lymph nodes, left axillary sentinel, excisions: Multiple (5) left axillary sentinel lymph nodes are. negative for tumor (blue dye identified in left axillary lymph node No. 1 only). Lymph nodes, left axillary, dissection: Multiple left highest (2) and left axillary (23) lymph nodes are. negative for tumor. Her-2/NEU has been ordered on paraffin embedded tissue.
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diff --git a/output/text/67048091-8884-4b1b-af14-e29669e1e42c.txt b/output/text/67048091-8884-4b1b-af14-e29669e1e42c.txt
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index 0000000000000000000000000000000000000000..d6a65537044199a6e6aeff4dd0ecb4fac0997d89
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+--- Page 1 ---
+SURGICAL PATHOLOGY: COPY TO:  Pre-Op Diagnosis Nothing indicated Post-Op Diagnosis Nothing indicated Clinical History Nothing indicated Gross Description: Received in a single container labeled "  - right colon". is a previously opened portion of large bowe! including cecum, as well as cm of previously opened portion of terminal ileum. The specimen is received after formalin fixation and shows the large bowel to measure 20.6 cm and the ileum to be 9.4 cm. The specimen is covered by a moderate amount of pericolic and epiploic adipose tissue in which an 8.0 x 0.6 x 0.6 cm grossly unremarkable vermiform. appendix is identified. The visible serosa is shaggy gray tan to brown. The wall is up to 0.6 cm edematous and fibrotic. The lumen is lined by gray-tan mucosa with preservation of intestinal folds. Noted within the cecal pouch extending to the ileocecal valve is a 4.6 x 3.0 cm centrally ulcerated finely granular tan-gray to pink lesion with raised rolled borders. This is stated during specimen opening to be noted at its nearest point 26 cm from the distal. margin and 14 cm from the proximai margin. This has a gritty gray tan fibrotic cut surface measuring up to 1.9 cm in thickness. This grossly extends focally through the muscularis into the surrounding adipose tissue where it is seen at its nearest point 0.7 cm from the nearest outer margin. In addition, in one area the lesion umbilicates to the serosa and grossly appears to extend through the serosa. No other gross lesions are identified. On sectioning, the surrounding adipose tissue shows several well defined and poorly defined gray tan nodules measuring up to 1.2 cm in greatest dimension. The largest nodules have fibrotic necrotic cut surfaces. Also received in the same container are three tissue cassettes each
+
+--- Page 2 ---
+labeled Representative sections are submitted Iabeled as tollows: A - proximal margin; B - distal margin; C- ileocecal valve; D-G - representative lesion and surrounding tissue; H - random uninvolved bowel; I - appendix; J-L - representative sections of grossly positive nodules; M-N - whole smaller pericolic nodules. Microscopic Description: The slides labeled. are examined. See diagnosis. Final Diagnosis Distal ileum and right colon (right hemicolectomy): Distal ileum: No pathologic diagnosis. PAS 1 Right colon: Tumor characteristics: Histologic type: Adenocarcinoma.. Location of tumor: Cecal pouch.. Size: 4.6 x 3.0 cm in greatest dimension. Grade: Moderately differentiated.. Lymphovascular space invasion: Yes. Perforation of Visceral peritoneum: Yes (see comment). Presence of mesenteric deposits: No. Depth of invasion: Carcinoma extends through muscularis propria into subserosal adipose tissue and focally perforates visceral peritoneum to involve serosal surface focally. Surgical Margin Status: Proximal Margin: No carcinoma identified. Distal Margin: No carcinoma identified. Deep Radial Margin: Carcinoma focally perforated visceral peritoneum to involve serosal surface focally (see comment). Distance of tumor from closet margin: See above diagnoses.. Lymph Node Status: Total number of lymph nodes examined: 17 Total number of lymph nodes with metastatic carcinoma: 11 (11/17) PAS 9 Appendix: Fibrous obliteration of the luminal tip, no carcinoma identified. PAS 4 SPC-A CPT: 88309 Stage: pT4aN2bVL (see comment) Comments Grossly in one area, the lesion umbilicated to the serosa and grossly appears to extend through the serosa. Microscopically,. carcinoma is present focally extending through the visceral peritoneum to focally involve the serosal surface. Therefore, this is staged as pT4a. Eleven of 17 lymph nodes demonstrate metastatic carcinoma. Some of the nodes are completely replaced by carcinoma with no residual nodal tissue identified. These are counted as lymph nodes totally replaced by tumor. Therefore, this is staged as a. pN2b. In addition, lymphovascular space invasion is identified and the additiona! classifications of VL are therefore used. The final stage should be performed in conjunction with knowledge of the clinical stage.. At the request of the undersigned pathologist, these slides have
+
+--- Page 3 ---
+been additionally reviewed by Dr.  who concurs with the. diagnosis.
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diff --git a/output/text/67082615-1510-46bb-a355-6fce223f959c.txt b/output/text/67082615-1510-46bb-a355-6fce223f959c.txt
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+
+--- Page 1 ---
+UUID:F9B6971F-23C0-465F-BFEC-778BF228A1AE Redacted Date : Gender: Female Color: White Origin: Nature of material: Breast Biopsy number: PATHOLOGY REPORT: Gross description: Received one piece of fibrofatty tissue measuring 2.2 x1.2 x 0.4 cm marked with shorts suture. On slicing in the central part is a white and firm area measuring 0.4 cm in the largest. diameter. zcD-0:3 Microscopy 'Qrcenoner , Isbular anjiltaterg NQS Dispensable description. D 85Q0|3 Conclusions: Site C Buesst46S Right breast wide excision: C 50.9 -Invasive lobular carcinoma, grade 1; yJ 5/a1114 Immunohistochemistry: e-cadherin: negative; ER: positive in 70%; PgR: positive in 20%, HER2: negative (score 1+) PARTICIPANTS OF APPRAISAL REPORT Issuer - Reviewer - Reviewer 214
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diff --git a/output/text/670f4c5b-a2f2-45c1-a888-a48c213b2bfc.txt b/output/text/670f4c5b-a2f2-45c1-a888-a48c213b2bfc.txt
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index 0000000000000000000000000000000000000000..fa6e0f67532c500690772a62244491501905efa3
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+
+--- Page 1 ---
+Page I of 3 UUID:37B70EEA-86D4-4373-820D-F42F04688B02 TCGA-SX-A7SO-01A-PR Redacted Result Type: Surgical Pathology Report. Result Date: Performed By: Encounter info: IcD -O 3 Surgical Pathology Report *Final* 82bO[ 3 Sut D+drey N6S C64.9 Surgical Pathology Report. FtJ io/4113 Clinic Number: Name: Requested By: DIAGNOSIS: A. Ascending and proximal transverse colon, appendix:. Specimen: Terminal ileum, cecum, ascending and transverse colon. Procedure: Right hemi- and transverse colectomy.. Tumor site: Ascending colon, 12 cm from ileocecal valve. Tumor size: 3.0 cm in greatest dimension. Tumor histologic type: Adenocarcinoma. Histologic grade: Moderately differentiated (grade 2 of 3). Microscopic tumor extension: Invasive adenocarcinoma, extends into the submucosa. No evidence of carcinoma penetrating into the underlying muscularis propria.. Margins: Proximal small bowel and distal colonic margins; negative for tumor. Distance to mesorectal margin: Not applicable. Lymph-vascular invasion: Not identified. Perineural invasion: Not identified. Tumor deposits (discontinuous extramural extension): Not present. Macroscopic completeness of mesorectum (if applicable): Not applicable. Lymph nodes: A total of twenty-two regional lymph nodes, negative for metastatic adenocarcinoma (0/22). Response to treatment: Not applicable. Additional findings: Separate inflammatory polyp, 0.6 cm in. greatest dimension, distal to the main tumor mass. Appendix, with fibrous obliteration.. Pathologic staging: pTl, pNO. Ancillary testing: Not performed. Block(s) containing malignancy suitable for further testing: Block A5. B. Left kidney tumor: Procedure/laterality: Left partial nephrectomy.. Histologic type: Papillary renal cell carcinoma, with eosinophilic Nuclear grade (Fuhrman, 1-4): 2 of 4. Tumor size: 7.0 cm in greatest dimension. Tumor site: Upper pole.. Tumor focality: Unifocal.. Sarcomatoid features: Not present. Tumor necrosis:. Not present..
+
+--- Page 2 ---
+Page 2 of 3 Microscopic tumor extension:. Extension into perinephric tissue: Not present. Extension beyond Gerota's fascia: Not present. Extension into renal sinus: Not present. Extension into renal vein: Not present.. Extension into collecting system: Not present. Extension into adrenal gland (if applicable): Not applicable.. Surgical margins: Fatty soft tissue margins; negative for tumor. Lymph-vascular invasion: Not identified. Lymph nodes: None present.. Pathologic findings in nonneoplastic kidney: No specific pathologic features. Pathologic staging: pTlb, pNX. Biorepository sample (if applicable): Representative section of. tumor and normal kidney are shown on block B6. Block(s) containing malignancy suitable for additional testing: B4.. DiAgnOSIS CoMMENt: Selected slides of the colectomy and nephrectomy specimens reviewed. with . CLINICAL INFORMATION:S Hepatic flexure cancer and left kidney renal cell carcinoma.. SPECIMEN(S) : A:Ascending and proximal transverse colon, appendix B:Lt kidney tumor. PRELIMINARY INTRAOPERATIVE DIAGNOSIS:S Intraoperative Pathologist(s): A. Ascending proximal transverse colon and appendix, gross. 3 cm). Relatively flat polyp identified more distally. B. Left kidney tumor, frozen section diagnosis: Papillary renal. cell carcinoma, no sarcomatoid features.. GROSS DESCRIPTION: Pathologist's Assistant. Performed by A. Received fresh labeled and "ascending and proximal transverse colon, appendix.". Specimen: Terminal ileum, cecum, ascending and transverse colon. Procedure: Right hemi- and transverse colectomy. Dimensions: 5.5 cm of terminal ileum and 50 cm of large bowel. Tumor site: Ascending colon, 12 cm distal to ileocecal valve. Flat, granular, pink-tan. Tumor configuration:. Tumor size: 3 x 2.5 x 0.5 cm. Tumor distance to nearest margin: Proximal, 17 cm. Distance to mesorectal margin (if applicable): Not applicable.. Macroscopic completeness of mesorectum: Not applicable. Tumor extension into fat: Not grossly identified.
+
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+Page 3 of 3 Tumor extension to inked free surface: No. Tumor perforation: No. Tumor deposits in fat: No.. Additional mass/polyp(s): Yes; 0.6 x 0.4 x 0.3 cm situated 8 cm distal to the main tumor. Lymph nodes: Twenty-three possible lymph nodes from 0.2 cm to 0.8 cm. Gross notes:. Additional findings: A grossly unremarkable 5 x 0.6-cm appendix encased by slightly hemorrhagic fat.. Block key for specimen A: Al) sample of each surgical margin; A2-A5) entire main tumor; A6) polyp; A7) appendix; A8) eight lymph nodes; A9) four lymph nodes; Al0) eight lymph nodes; All0 three lymph nodes.. B. Received fresh labeled and "left kidney tumor.". Procedure: Partial nephrectomy.. Specimen laterality: Left.. Tumor site: Upper pole. Tumor size: 7 x 5 x 5 cm. Tumor  focality: Unifocal. Gross extent of tumor: Extension into perinephric tissue: Absent. Extension beyond Gerota's fascia: Absent. Extension into renal sinus: Absent. Extension into renal vein: Absent.. Extension into collecting system: Absent.. Adrenal gland: Not identified. Gross notes: Gross tumor characteristics: Soft, gray-brown, predominately solid. Kidney weight: 325 g with fat, 135 g without fat.. Specimen dimensions: Overall 1l x 8 x 7 cm. Distance to margin: 0.3 cm grossly from parenchymal margin. Lymph nodes: None identified.. Inking details: The parenchymal margin and the Gerota's fascia surface are inked blue. Biorepository sample submitted: Yes, see block key.. Block key for specimen B: Bl) Frozen section sample of tumor; B2-B4) additional samples of tumor; B5) inked fatty soft tissue margin; B6) mirror images of biorepository sample (normal and tumor), Support for the diagnosis in this case may have included the use of immunohistochemistry tests that were developed and whose performance characteristics were determined by. They have not been cleared or approved by the U.s. Food and Drug Administration (FdA). The FDA has determined that such clearance or approval is not necessary. These tests should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 ('cLIA') as qualified to perform high complexity clinical laboratory testing. 89
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diff --git a/output/text/67435622-6675-4cfb-9ef8-10532de933fd.txt b/output/text/67435622-6675-4cfb-9ef8-10532de933fd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5c9b1982ed92f92e6d122eddb70ae0e971e163ba
--- /dev/null
+++ b/output/text/67435622-6675-4cfb-9ef8-10532de933fd.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SPECIMENS: A. RIGHT COLON RESECTION B. LIVER BX DIAGNOSIS: RIGHT COLON, RIGHT HEMICOLECTOMY: - EXOPHYTIC ULCERATED INVASIVE MODERATELY DIFFERENTIATED ADENOCARCINOMA OF CECUM ARISING IN TUBULOVILLOUS ADENOMA WITH FULL MUSCLE WALL THICKNESS INVASION AND EXTENSION TO SUBSEROSAL FAT, METASTASIS TO TWO OUT OF TEN PERICOLIC LYMPH NODES (2/10). - PROXIMAL AND DISTAL MARGINS OF RESECTION, NEGATIVE FOR TUMOR. - SIZE OF TUMOR -4 X 3.7 X 3.5 CM. LIVER, BIOPSY: - METASTATIC ADENOCARCINOMA CONSISTENT WITH METASTASIS FROM THE ABOVE CECAL ADENOCARCINOMA COLORECTAL CANCER TEMPLATE Tumor Size (cm): 4 x 3.7 x 3.5 cm Histologic Type: Adenocarcinoma Grade/Differentiation: G2, Moderate Invasion Depth: Subserosa  Invasion Vasc/Lymphatic: no Invasion Perineural: Absent Extension to Adj. Areas:. No Margins: Free Lymph Nodes:  N1, Positive (2/10) Stage Pathology: pT3N1 Implants: Absent Precursor: Present - tubulovillous adenoma Non-neoplastic areas:. Staging: Tis: CIS  T1: Submucosa, Intraepithelial or invasion of lamina propria T2: Into muscularis propria. T3: Thru muscularis propria T4: Thru peritoneum or to other areas  Includes invasion of other segments of the colorectum by way of the serosa Regional Lymph Nodes (N) NO: No lymph node metastasis N1: 1-3 Lymph nodes positive N2: ? 4 Lymph nodes positive 7-14 Lymph nodes should be examined SPECIMEN(S): A. RIGHT COLON RESECTION B. LIVER BX CLINICAL HISTORY: with ca. colon GROSS DESCRIPTION:
+
+--- Page 2 ---
+RIGHT COLON RESECTION Specimen consists of resected short segment of right colon measuring 15 cm in length.,with attached adherent indurated adipose tissue. Large firm palpable mass occupies mid portion of the specimen ,which when the specimen is opened, shows an obstructing circumferential exophytic tumor measuring 4 x 3.7 x 3.5 cm, involving cecum and extending to ileocecal valve and seen 3 cm from ileal margin and 6 cm from distal colonic margin of resection. The tumor on sections shows a tan-cream-white surface and infiltrates entire colonic wall with apparent extension to subjacent adipose tissue. Tumor occludes cecal lumen. Attached adipose tissue measures 11 x 5 x 2.5 cm. Appendix is not identified. Multiple sections submitted and labelled as follows. A1-A4: one transverse section of tumor divided into four sections A5-A7: additional tumor representative. A8: colonic margin A9: representative of colon A10: representatives of ileum A11: distal ileal margin A12: three lymph nodes, one bisected and inked. A13: three lymph nodes, one inked and bisected. A14: three lymph nodes A15: one bisected lymph node LIVER BIOPSY Received in formalin is a portion of tan brown soft tissue measuring 1.2x0.7x0.5cm. which is previously partially bisected. The specimen is further sectioned and submitted completely in cassette B.
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diff --git a/output/text/6760d5e1-4a1e-463f-8da2-af8db638b719.txt b/output/text/6760d5e1-4a1e-463f-8da2-af8db638b719.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e11fc2265ba4b6e58d308f0ccc4ba343b19b88f2
--- /dev/null
+++ b/output/text/6760d5e1-4a1e-463f-8da2-af8db638b719.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+.aav crrorop.eneAype A.CECECARCNMA mc bagen tt dees not avane per nophric adiposo tissse recr. artury and vean maigins are negative for umor. wchovascuiar invasjon is nct dcntiied. Acc assifcation 6tn Edition pb Nx Mx. Tho non-reop astic kidncy wii be evaluated by Renai Pathology and tne ind ngs wii ce reported in an addendun. SPHOMEN LABELEO KEGIONAL. REROPERITONEAL LYMPH NODE Fibrorascula and adipose tlssve with no tamor present. Lympnoid t ssue is nct identitieo. CHTNICAD TATA: carcinomu. et. radcai nephrectomy. regional iyrphaderectomy operaton Le. renai carcnoma. Clinca Ciagncsis: TISUEPUEMTTE: Ai. et k.drey Regcnu. retoperitonca! iymph node 32. LEOCRPN Ir cw yascach obe.ed wah the pat ent's   p. kare ke atery 0.cm.engtn x 0.8 cm n pon sest ioning ley.h C.6 c in darnter, ard vein a/pink0 tan/ acs4.53.0x4.2cm The mas a misinoduiar there showing 10 h ibroc capsule NC The cusg.ns. No otner Jross remuinier f he kidey parenchyma is brown/tan and unremarkabe. rhotograp ae taken. Reprcsentative sections of normal 1.nosjuoreacence fra arrery and vein margins McAlUrcter TL. rug ack fx Lumo 1frag McroA mp noacs Carddore .Regorai re.roperironou Ivapn soces.coreise
+
+--- Page 2 ---
+1yph nodes. aggregate w:ho any defin.tvn The entie speciren is suhmit:cd tcr histologic exam nution Micro BMu Srags By his/her signature beow, the senior phya.cian cerifies tha. ke/she of the described specimen(s and rendcred cr confirmec the diagnosisies) relatcd nereto. ASCENDIM: RENA PATHOHOGY EYALUATRON CFKEDNRY FAREKSHTYA LEPTRADCANEPHRECTOMY BULAR AROPHY AN INTERSTITAL FIBRCSIS 1C OF THR PARENCHYMA -ARTERIOLAR SCLERCSISMOCERATE SEE NOTK NOTE: re kdnsy parenchyra sarple cxarined shors mla to moderate chronic changes as surmarizod above. The kidey parenchyma has been reviewed by MICROSCOPC DESCRIPTION: Secnions cf formainfixed parafin erbedded issue (block A6) wcre cva uated sing Has PAsJoncssiiver meshonamine, and AFc (ttienrome) stains by lght r.croscopy. The sanple consists o cortex and medu. which 7.ot are gobaly sclerosed There are 220 gomerui present, e ronaiing glomeral show Socal hore areno dscornb ca.err cr deun contos c che glomorulay capiary wai casemcns memnrarcs.Sevora.cfLe cortca parensyma ahowe cub:lar asrephy ad inersrtia r:brns and arteric.cs exhini a mcderace dcgrce nf elcoss Artere Page.20r
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diff --git a/output/text/67a7a3f2-6cb3-4f39-b84c-a8d3507f9f4d.txt b/output/text/67a7a3f2-6cb3-4f39-b84c-a8d3507f9f4d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6f4d36a4c682d7d98c8d8ea2376b7e25234c544b
--- /dev/null
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+--- Page 1 ---
+Jcs-0 - 3 Fatient. QcF: brust,N63 C50.9 Surgical Pathology: Fina! Surg Path CLINICAL HISTORY: Breast cancer. GROSS EXAMINATION: A. "Left breast and axilla", received fresh. The specimen is a 22.7 x 11.5 x 2.5 cm mastectomy specimen. The overlying skin ellipse measures 17.0 x 11.0 cm, and includes a 5.5 cm areola and 1.0 cm nipple. ~A well-healed 3.0 cm scar is noted just superior to the areola in the upper inner quadrant. The specimen includes an axillary tail which measures 11.0 cm x 7.0 cm. The margins of the specimen are inked in blue, and the specimen is serially sectioned to reveal a 3.5 x 3.5 x 3.0 cm tumor in the upper inner quadrant, extending medially to the upper outer quadrant. The tumor is firm, tannish-white, with a gritty consistency. It appears to be infiltrating. adjacent tissue. Tissue has been sent for estrogen and progesterone receptor assays. The tumor approaches to 1 cm of the deep margin. It approaches to 1.0 cm to the lateral margins. The remainder of the breast tissue is composed of lobular adipose tissue intermixed with reddish pink fibrous tissue. There is an area of dense white fibrous breast tissue in the upper outer quadrant. The axillary tail measures 13.5 x 8.0 cm. It is composed of yellow lobular adipose tissue. Several nodes are identified grossly. A 3.1 x 1.0 cm node is sectioned to reveal a firm 2.0 x 1.0 cm tan-white mass. The axillary tail is amputated, divided into three sections and searched for lymph nodes which are submitted as described below.. Block Summary: Al- section of skin through nipple and areola. UUID:4379DEE0-F7CB-4A73-8828-21EA0AA830F5 A2- section of breast through overlying skin with scar.. TCGA-B6-A0IG-01A-PR Redacted A3- section of deep margin of tumor. A4- section of deep margin of tumor. A5- section of lateral margin of tumor. A6- section of tumor. A7- section of tumor. A8- section of tumor, with possible biopsy cavity. A9- tissue from the upper inner quadrant. A10- tissue from the lower inner quadrant. A11- tissue from lower outer quadrant. A12- tissue from upper outer quadrant. A13-one grossly positive lymph node, section I. A14-one lymph node, sectioned, section I. A15- six lymph nodes, section II. A16- three lymph nodes, section II. A17- one lymph node , sectioned, section II. A18- three lymph nodes, section III. Al9- one lymph node, sectioned, section III. A20- three lymph nodes, section III. MICROSCOPIC EXAMINATION: The previous biopsy site is located in the center of a large tumor mass consisting of infiltrating ductal carcinoma. Positive lymph nodes are tail, 2/2 (one macroscopically positive with extracapsular extension); mid axillary tail, 2/8; high axillary tail, 0/6. DIAGNOSIS: A. "LEFT BREAST AND AXILLA"; MODIFIED RADICAL MASTECTOMY:S 1. RESIDUAL INFILTRATING DUCTAL CARCINOMA, NSABP NUCLEAR GRADE 2/3,S eBrowser Result fo! 1 of 2
+
+--- Page 2 ---
+HISTOLOGIC GRADE 3/3. RESIDUAL TUMOR SIZE 3.5 X 3.5 X 3.0 CM. 3. FOCAL DUCTAL CARCINOMA IN SITU, COMEDO TYPE. FOCAL VASCULAR INVASION IS IDENTIFIED. 4. NIPPLE, NO PAGET'S DISEASE IDENTIFIED.  SKIN WITH HEALING SCAR. NO DERMAL LYMPHATIC INVASION IDENTIFIED. 6. 7. ALL SURGICAL MARGINS ARE FREE OF TUMOR.  REMAINING BREAST WITH PAPILLARY APOCRINE METAPLASIA, CYSTIC CHANGE, AND 8. INTER- AND.INTRALOBULAR FIBROSIS. 9. METASTATIC ADENOCARCINOMA INVOLVING 4 OF 16 TOTAL AXILLARY LYMPH NODES. ONE LYMPH NODE IN THE LOW AXILLA IS MACROSCOPICALLY POSITIVE AND EXHIBITS EXTRACAPSULAR INVASION BY TUMOR. Verified by: 2 of 2
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diff --git a/output/text/67d08a00-5f48-431d-b841-7aa982c34476.txt b/output/text/67d08a00-5f48-431d-b841-7aa982c34476.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a476cb1537e01ce554d544ebf14b008b97bfd4a1
--- /dev/null
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+
+--- Page 1 ---
+1cd-0-3 Caucioma, mifiltnat'ny ductal, Nos 85oo/3 PsH Sin:bunt,uoq C50.4 1/25/1 CQCF Sit: busot, nos c50.9 Diagnosis: Ablated breast sample with a multifocal poorly differentiated invasive ductal carcinoma (tumor diameter: 7 cm, 2.2 cm and 1.7 cm), the largest tumor focus with focal ulceration of the skin and circumscribed intraductal spread. Focal angioinvasion. Tumor-free dorsal resection margin. Together with the preliminary finding, this gives rise to the following tumor classification: NOS, G IIl, pT4b(mult)N3aL1V0R0. UUID: 81ADDBAB-C02F-4DA8-9429-76293FB42E42 TCGA-A8-A079-01A-PR
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diff --git a/output/text/67d125b1-bdbd-4919-960e-e8d4e62454b1.txt b/output/text/67d125b1-bdbd-4919-960e-e8d4e62454b1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e7b5a7c9c410eb9734c76ea1c744a4d5e975eeed
--- /dev/null
+++ b/output/text/67d125b1-bdbd-4919-960e-e8d4e62454b1.txt
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+
+--- Page 1 ---
+SURGICAL PATHOLOGY 1cD-0-3 Case Number : Saumu, Ninsl cell Diagnosis: chromophoh< type 8317f3 A: Kidney, right, partial nephrectomy Sitx: C Kisny,n1s Cb49 Procedure: partial nephrectomy Laterality: right 8/u|13 Histologic tumor type/subtype: eosinophilic variant of chromophobe renal cell carcinoma Sarcomatoid features: absent Histologic grade (if applicable): Fuhrman 2 (of 4) Tumor size (greatest dimension): 3.8 cm, gross measurement Tumor focality: unifocal. Extent of tumor invasion (if present specify if macroscopic or microscopic): Capsular invasion/perirenal adipose tissue: tumor invades into but not through the renal capsule, does not involve perirenal adipose tissue Gerota' s fascia: not applicable Renal sinus: not applicable Major veins (renal vein or segmental branches, Ivc): not applicable UUID:086608D4-B3A4-437E-BA67-BA51E206D45D Redacted TCGA-UW-A72P-01A-PR Ureter: not applicable Venous (large vessel): absent Lymphatic (small vessel): absent Histologic assessment of surgical margins: Renal parenchymal margin (partial nephrectomy only): negative but close, tumor is <l mm from the black inked parenchymal margin (blocks A2, A3) Renal capsular margin (partial nephrectomy only): negative but close, tumor is <1 mm from the blue inked capsular margin (A4) Paranephric adipose tissue margin (partial nephrectomy only): not applicable, no perinephric adipose tissue present in specimen
+
+--- Page 2 ---
+Adrenal gland: not present in specimen. Lymph nodes: none present in specimen. Pathologic findings in non-neoplastic kidney: no specific pathologic abnormalities AJcc Staging: pT1a pNx This staging information is based on information available at the time of this report, and is subject to change pending clinical review and additional information. Clinical History: -year-old female with right renal mass.. Gross Description: Received is one appropriately labeled container, additionally labeled "right renal mass partial nephrectomy." Specimen fixation: formalin Type of specimen: partial Side of specimen: right Size and weight of specimen: 45.7 grams, 5.5 x 5.0 x 4.4 cm. Orientation: The capsule is inked blue and the parenchymal margin is inked black. Presence/absence of adrenal gland: absent. Tumor site: cortical, cortex into medulla Tumor description: The mass is well circumscribed, encapsulated, friable, tan/pink Tumor size: 3.8 x 3.6 x 3.4 cm Presence/absence of multicentricity: Absent Confinement/non-confinement to the kidney: confined
+
+--- Page 3 ---
+Extent of invasion:. Perirenal adipose tissue: grossly does not involve Gerota' s fascia: grossly does not involve Renal vein: N/A Ureter: N/A Renal Sinus: N/A Pelvicaliceal: involved Adrenal: n/a Other organs: not submitted Surgical margins: The mass grossly abuts the black inked surgical margin and abuts but does not invade through the capsule margin (blue ink). Description of kidney away from tumor: The remaining kidney is red/tan with normal architecture. Hilar lymph nodes: n/a. Other significant findings: none Tissue submitted for. tumor for Digital picture: not taken Block summary: Al-A3 - representative sections of tumor with closest approach to black inked margin. A4 - tumor with closest approach to blue inked capsular margin A5 - tumor with adjacent normal A6 - kidney uninvolved by tumor Tissue remains in formalin.
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diff --git a/output/text/67d95f3f-abc1-4878-9d67-931b3dd91a18.txt b/output/text/67d95f3f-abc1-4878-9d67-931b3dd91a18.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2e3bba1cedd8c041ee63829f5fbc7f8759930e97
--- /dev/null
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+
+--- Page 1 ---
+UUID:9A3E09B9-414B-4791-8F75-FF33EB6A5D6F TCgA-2Z-A93T-01A-PR Redacted Pathology Report Final Diagnosis. A. DEEPMARGIN RIGHT KIDNEY: Benign renal parenchyma. B. RIGHT KIDNEY,PARTIALNEPHRECTOMY Renal cell carcinoma, papillary type Il. See Key Pathologic Findings. Surgical margins, free of malignancy. Pathologic stage: pT1a NX MX. ADDITIONAL RIGHT CYSTIC WALL: Benign adipose tissue. the attending pathologist, personally reviewed all siides and / or materials and rendered the final diagnosis. Electronically signed out by ID0-3 Key Pathological Findings PROCEDURE: ceQ0 8q60/3 Partial nephrectomy SPECIMEN LATERALITY: Sit:D BiolneyNoS Cb4.9 Right TUMOR SIZE (largest tumor if multiple): Dimension: 2.9 cm TUMOR FOCALITY: 4Q8/1y Unifocal MACROSCOPIC EXTENT OF TUMOR: Tumor limited ta kidney HISTOLOGIC TYPE:  Papillary renal cell carcinoma. SARCOMATOID FEATURES: Not identified TUMOR NECROSIS: Present 10% HISTOLOGIC GRADE (Fuhrman Nuclear Grade): G3: Nuciei very irregular, approximately 20 microns; nucleoli large and prominent MICROSCOPIC TUMOR EXTENSION: Tumor limited to kidney MARGINS: Margins uninvolved by carcinoma PERINEURAL INVASION: Absent ANGIOLYMPHATIC INVASION: Absent LYMPH-VASCULAR INVASION: Absent PRIMARY TUMOR (pT): pT1a:Tumor 4 cm or less in greatest dimension, limited to the kidney
+
+--- Page 2 ---
+REGIONAL LYMPH NODES (pN): pNX: Regional lymph nodes cannot be assessed DISTANT METASTASIS (pM): pMX Specimen(s) Received A DEEP MARGIN RIGHT KIDNEY FS B RIGHT PARTIAL NEPHRECTOMY c ADDITIONAL RIGHT CYSTIC WALL Clinical History History of prostate cancer Preoperative Diagnosis. Renal mass Intraoperative Consultation FSA1. DEEP MARGIN RIGHT KIDNEY: No tumor identified. Comment: This frozen section diagnosis/result was communicated to and acknowledged by Dr have performed the intraoperative consultation and issued the above diagnosis. Gross Description A. The specimen is received fresh for frozen section consult, labeled *deep margin right kidney." The specimen consists of an unoriented, red-tan, rubbery fragment of renal tissue, 0.6 x 0.5 x 0.3 cm.. . The specimen is submitted entirely intact in FSA1. The specimen is not submitted for Tissue Procurement Laboratory. B The specimen is received fresh,labeled *right partial nephrectomy and consists of an unoriented, encapsulated, rubbery nodule, 7.5 grams, 2.9 x 2.8 x 2.2 cm. The capsule is intact with focal adhesions, and inked black. Sectioned, the cut surfaces exhibit dark tan, smooth, congested spongy tissue with glistening surfaces, comprising the entire specimen. Normal renal parenchyma is. not identified. The tissue extends to the capsule, however, does not extend through. Necrosis up to 10% is noted with focal nemorrhage. Representative sections are submitted in B1-B4. The specimen is submitted to Tissue Procurement Laboratory, as reflected in cassette B4.. C. The specimen is received fresh, labeled *additional right cystic wall.* The specimen consists. of an unoriented,pale white,soft fatty tissue,7 mm. The specimen is submitted entirely intact in C1. The specimen is not submitted for Tissue Procurement Laboratory. lw 3/14 DISQUALIFIED
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diff --git a/output/text/6832acc5-c305-4c31-b779-624d39c1a6e4.txt b/output/text/6832acc5-c305-4c31-b779-624d39c1a6e4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..656799404f05c2b6c8106c6e533be43bad018b1f
--- /dev/null
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+
+--- Page 1 ---
+SURGICAL PATHOLOGY Surgical Pathology Report Diagnosis: Colon, right, colectomy Tumor Histologic Type: Invasive adenocarcinoma with mucinous features Histologic Grade: Moderately differentiated Tumor Location: Cecum with extension into ileocecal valve Depth of Invasion: Through muscularis propria into the pericolic soft tissue. Lymphovascular Invasion: Not identified Perineural Invasion: Not identified. Margins: Proximal margin: Negative, 4 cm from tumor Distal margin: Negative, 8 cm from tumor Circumferential (radial) margin (rectal tumors only): Not applicable Mesenteric margin: Negative, 8 cm from tumor Distance of carcinoma from closest margin (specify): 4 cm to proximal Regional Lymph Nodes: Total number with metastasis: 1. Total number examined: 19 Additional pathologic findings: Focal abscess formation adjacent to tumor AJCC PATHOLOGIC TNM STAGE: pT3 pN1a Note: This pathologic stage assessment is based on information available at the time of this report, and is subject to change pending. clinical review and additional information. Comment: Multiple enlarged lymph nodes without carcinoma were identified. These lymph nodes contained numerous follicles that appeared reactive. However, due to the large size of the lymph nodes, the number of follicles, and the patient' s age, immunostains for BCL2 CD3 and CD20 were performed to exclude follicular or another low grade lymphoma. These stains reveal a benign reactive pattern. with no evidence of lymphoma.. Clinical History: cecal cancer. Gross Description: Specimen fixation: formalin Parts of bowel received: terminal ileum, cecum and ascending colon with attached fat. Specimen length: The terminal ileum is 4.5 cm in length and the large bowel is 12 cm in length.. Orientation: The cecal pouch where the tumor is inked blue.. Tumor dimensions: 6.5 x 4.7 x 1.3 cm with a mucinous cut surface. Gross appearance of tumor: Central cratered ulcer with raised rolled borders, broad based configuration Circumferential growth: n/a; in cecal pouch Gross depth of invasion: through the muscularis propria and into the subjacent fat of the cecum. Gross evidence of perforation through visceral peritoneum: no
+
+--- Page 2 ---
+Luminal obstruction: no Bowel circumference at tumor site: n/a (in cecal pouch). Gross distance of tumor from margins: The tumor is located 4 cm from the proximal margin, 8 cm from the distal margin, 8 cm from. the radial mesenteric margin and focally abuts the deep blue inked serosa. Lymph nodes: submitted as per block summary. Other remarkable findings: The remaining mucosa is velvety tan, and grossly unremarkable. The wall has a uniform thickness of. 0.3 cm. No appendix is grossly identified. The mass focally extends onto the ileocecal valve. Tissue submitted for special investigation: Tumor and normal are given to Tissue Procurement. Digital photograph taken: no Block Summary: A1 - en face proximal margin A2 - en face distal margin A3 - en face radial mesenteric margin A4 - one lymph node candidate, bisected at radial mesenteric margin. A5-A8 - full thickness sections of tumor to include relationship to inked. serosa and subjacent fat A9 - tumor spanning ileocecal junction. Lymph node candidates measuring up to 2 cm in greatest dimension are identified. A10 - four lymph node candidates A11 - three lymph node candidates A12 - one lymph node candidate, trisected A13-A14 - one lymph node candidate, sectioned (largest). A15 - two lymph node candidates A16-A19 - one lymph node candidate, serially sectioned A20 - six lymph node candidates A21 - two lymph node candidates Light Microscopy: Light microscopic examination is performed by Dr. For cases in which immunostains are performed, the following applies:. Appropriate internal and/or external positive and negative controls have been evaluated. Some of the immunohistochemical. reagents used in this case may be classified as analyte specific reagents (AsR). These were developed and have performance characteristics determined by the. These reagents have not been cleared or approved by the US Food and Drug Administration (FDA). The FDA has determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for research. This. Iaboratory is certified under the Clinical Laboratory Improvement Amendments of ) as qualified to perform high complexity clinical laboratory testing. Signature Attending Pathologist: I have personally conducted the evaluation of the above specimens and have rendered the above diagnosis(es).
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diff --git a/output/text/6887be80-a617-40b5-ad27-59187b93d784.txt b/output/text/6887be80-a617-40b5-ad27-59187b93d784.txt
new file mode 100644
index 0000000000000000000000000000000000000000..347df90a5ee057f6e373ad7ebe7bbbb44f478930
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+
+--- Page 1 ---
+UUID: 7853A0D4-E13E-4573-B0A2- BB55AE54BD62 TCGA-S3-A6ZF-01A-PR Redacted MRN: Patient: Sex/DOB: Female Admission Date: Discharge Date: Ordering Physician: Pathology Addendum Report Collected Date/Time: Accession Number: Received Date/Time: Addendum Report ASSAY PERFORMED: HER2 GENE AMPLIFICATION BY DUAL IN SITU HYBRIDIZATION USING THE HER2 Dual ISH DNA PROBE COCKTAIL zcD o-3 aseinoms, j ingisuoting duet-NOs Number of nuclei scored: 20 8ss0|3 Total HER2 signals: 60 RyCaF=0 Total CHR 17 signals: 39 St 9usstN0S c sO.9 HER2/CHR 17 ratio: 1.5 R Asraes,cuppur suter guadas INTERPRETATION: - NEGATIVE FOR HER2 GENE AMPLIFICATION. 0cse>.4 JJ8/2113 NOTE: THE ASSAY WAS PERFORMED AS A REFLEX TEST AFTER THE HER2/NEU IMMUNOSTAIN WAS 2+. SPECIMEN TYPE: The HER2 is performed on a formalin-fixed paraffin-embedded tissue slide from block C3. DESCRIPTION OF THE ASSAY: The HER2 assay enables the HER2 gene and Chr17 centromere to be co-hybridized and visualized via light microscopy on the same slide. Specifically for this assay,. HER2 is detected by a dinitrophenyl (DNP) labeled probe visualized utilizing  SISH DNP (silver in situ hybridization) detection kit. The Chr17 centromere is targeted with a digoxigenin (DIG) labeled probe and detected using. ISH DIG detection kit. Dual ISH staining results in visualization by light microscopy and which HER2 appears as discrete black signals (SISH) and Chr17 as red signals in nuclei of normal cells serving as internal positive control for staining) as well as in carcinoma cells. SLIDE SCORING: Once an adequate target area is identified the reader records the scores for HER2 and Chr17 copy numbers that are present in 20 representative nuclei. If the resulting HER2 / Chr17 ratio falls within 1.8-2.2 (EQUrvOCAL) the reader is recommended to score an additional 20 nuclei and theresulting ratio is calculated from the total 40 nuclei. HER2 gene status is reported as non-amplified (HER2/ Chr17 < 2.0) or amplified (HER2/Chr17  2.0) Printed by: Page 1 of 7 Print Date/Time: Copied to: Distribute to: Patient Locations:
+
+--- Page 2 ---
+MRN: Patient: Sex/DOB:  Female Pathology Addendum Report. Collected Date/Time: Accession Number: Received Date/Time: f this assay were determined by. i$ assay has been approved by the U.S. Food and Drug Administration. This laboratory is certified under tnc Cun. Laboratory Improvement Amendments of 1988 (CLIA-88) as qualified to perform high-complexity clinical laboratory testing. cpt: 88368 x2 (Electronic signature) Verified: Collected Date/Time: Accession Number: Received Date/Time: Addendum Report IMMUNOHISTOCHEMICAL EVALUATION OF ESTROGEN RECEPTORS, PROGESTERONE RECEPTORS, AND HER-2NEU IN INVASIVE MAMMARY CARCINOMA . ESTROGEN RECEPTORS: 99 %, positive. PROGESTERONE RECEPTORS: 40 %, positive. STAINING INTENSITY:moderate HER-2NEU: SCORE 2+, EQUIVOCAL. Immunohistochemical studies were performed on formalin fixed paraffin embedded tissue (Block C3) using the following monoclonal antibodies: Estrogen receptor (Clone SP1), Progesterone receptor (Clone 1E2) and Her-2neu. Clone 4B5); control sections for HER-2Neu are provided within a kit (score 0 MCF-7, score 1+ T-47D, score 2+ MDA-MB-453, score 3+ BT-474). Detection system used: polymer. Primary antibodies. reagents and control sections for HER-2neu are all provided by* All controls show appropriate reactivity.. Reactivity of Estrogen and Progesterone receptors is determined based on the percentage of positively stained nuclei of tumor. cells. Reference values (CAP accreditation program checklist 2010 and guidelines on webpage): Positive: nuclear staining in 1% or greater than 1% of invasive carcinoma cells. Negative : nuclear staining in less than 1% of invasive carcinoma cells Staining intensity: is reported as weak, moderate or strong.. HER-2neu reactivity is reported applying the CAP scoring guidelines (CAP accreditation program checklist 2010 and guidelines on webpage): Score 0 = Negative: No immunoreactivity, or faint weak immunoreactivity in <10% of tumor cells but only a portion of the. membrane is positive. Score 1 = Negative: Faint weak immunoreactivity in 10% or >10% of tumor cells but only a portion of the membrane is positive.. Score 2+ = Equivocal: Weak to moderate complete membrane immunoreactivity in >10% of tumor cells or. Page 2 of 7 Print Date/Time
+
+--- Page 3 ---
+MRN: Patient: Sex/DOB: Female Pathology Addendum Report Collected Date/Time: Accession Number: Received Date/Time: circumferential intense membrane staining in <30% of cells. Score 3+ = Positive: More than 30% of the tumor cells must show circumferential intense and uniform membrane staining. A homogeneous (chicken wire) pattern should be present. Equivocal results for HER-2neu (Score 2+) will be subsequently followed by a reflex dual-color ISH testing. :y have not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for research. This laboratory is certificd under the Clinical Laboratory Improvement Amendments of 1988 (CL1A-88) as qualified to perform high-complexity clinical laboratory testing. (Electronic signature) Verified Surgical Pathology Report Collected Date/Time: Accession Number: Received Date/Time: Final Diagnosis A. RIGHT BREAST, CORE BIOPSY: - INVASIVE DUCTAL CARCINOMA B. RIGHT SENTINEL LYMPH NODE, BIOPSY: - NO EVIDENCE OF CARCINOMA IN ONE LYMPH NODE -SEE SPECIAL STAINS SECTION. C. RIGHT BREAST, TOTAL MASTECTOMY: - INVASIVE DUCTAL CARCINOMA GRADE 2, 2.5 CM. - MARGINS OF RESECTION ARE FREE OF CARCINOMA. - SEE SYNOPTIC REPORT, SPECIAL STAINS SECTIONS AND NOTE. NOTE: hormonal receptors and Her2-neu status will be reported in an addendum. (Electronic signature) Verified: Synoptic Report SPECIMEN: Total breast (including nipple and skin) PROCEDURE: Total mastectomy (including nipple and skin) Page 3 of 7 Print Date/Time:
+
+--- Page 4 ---
+MRN: Patient: Sex/DOB:  Female Surgical Pathology Report Collected Date/Time: Accession Number: Received Date/Time: LYMPH NODE SAMPLING: Sentinel lymph node(s) SPECIMEN INTEGRITY: Single intact specimen (margins can be evaluated) SPECIMEN SIZE: Greatest dimension: 26 cm Additional dimensions: 17 x 6 cm. SPECIMEN LATERALITY: Right TUMOR SITE: INVASIVE CARCINOMA: Upper outer quadrant TUMOR SIZE: SIZE OF LARGEST INVASIVE CARCINOMA: Greatest dimension of largest focus of invasion over 0.1 cm: 2.5 cm. Additional dimensions: 2.0 x 2.0 cm TUMOR FOCALITY: Single focus of invasive carcinoma MACROSCOPIC AND MICROSCOPIC EXTENT OF TUMOR: Skin: Invasive carcinoma does not invade into the dermis or epidermis DUCTAL CARCINOMA IN SITU (DCIS): DCIS is present Extensive intraductal component (EIC) negative. SIZE (EXTENT) OF DCIS: Estimated size (extent) of DCIS (greatest dimension using gross and microscopic evaluation) is at least 0.3 cm (constituting about 5% of the entire tumor mass.). ARCHITECTURALPATTERNS: Comedo Cribriform NUCLEAR GRADE: Grade III (high) NECROSIS: Present, central (expansive "comedo" necrosis) LOBULAR CARCINOMA IN SITU (LCIS): Not identified HISTOLOGIC TYPE OF INVASIVE CARCINOMA:S Invasive ductal carcinoma (no special type or not otherwise specified) GLANDULAR (ACINAR)/TUBULAR DIFFERENTIATION: Score 2: 10% to 75% of tumor area forming glandular/tubular structures NUCLEAR PLEOMORPHISM: Score 3: Vesicular nuclei, often with prominent nucleoli, exhibiting marked variation in size and shape, occasionally with very large and bizarre forms MITOTIC COUNT: Score 2 OVERALL GRADE: Grade 2: scores of 6 or 7 MARGINS: Margins uninvolved by invasive carcinoma  Page 4 of 7 Print Date/Time:
+
+--- Page 5 ---
+MRN: Patient: Sex/DOB: Female Surgical Pathology Report Collected Date/Time: Accession Number: Received Date/Time: Distance from closest margin: 25 mm Distance from posterior margin: 25 mm Margins uninvolved by DCIS (if present). Distance from closest margin: posterior mm Distance from posterior margin: 25 mm LYMPH-VASCULAR INVASION: Present DERMAL LYMPH-VASCULAR INVASION: Not identified LYMPH NODES: Number of sentinel lymph nodes examined: 1 (no tumor seen). Total number of lymph nodes examined (sentinel and nonsentinel): 1 METHOD OF EVALUATION OF SENTINAL LYMPH NODES: H&E, multiple levels Immunohistochemistry PRIMARY TUMOR (INVASIVE CARCINOMA (pT): pT2: Tumor >20 mm but less than or equal to 50 mm in greatest dimension REGIONAL LYMPH NODES (pN):  pNO: No regional lymph node metastasis identified histologically. DISTANT METASTASIS (M): Not applicable ADDITIONAL PATHOLOGIC FINDINGS: intraductal papilloma MICROCALCIFICATIONS: Present in DCIS Source of Specimen A Core Biopsy, RT Breast B Lymph Nodes, Sentinel Right c RT Total Mastectomy Clinical Information Palpable mass upper central FNAB positive, patient with right breast mass PRE-OP DIAGNOSIS: Right breast cancer POST-OP DIAGNOSIS: Same TYPE OF PROCEDURE: Right mastectomy and sent to the node biopsy Gross Description Specimen is received in 3 parts: A. The specimen is labeled "CORE BIOPsy" and is received unfixed for frozen section diagnosis. It consists of 2 cylindrical pieces of gray-tan soft tissue each measuring 1.5 cm in length and 0.1 cm diameter. Entirely submitted in cassette FSA 1. Time specimen was removed from the patient. Time specimen was placed in formalin Page 5 of 7 Print Date/Time:
+
+--- Page 6 ---
+MRN: Patient: Sex/DOB: Female Surgical Pathology Report Collected Date/Time: Accession Number: Received Date/Time: Ischemic time: 20 minutes B. The specimen is Iabeled "RIGHr SENTINEL NODE" and is received unfixed for frozen section diagnosis. (Specimen is in formalin mother 6 hour and less than 48 hours). It consists of a ymph node measuring 1.6 x 1 x 0.5 cm. Sectioned and entirely submitted in cassette FSB 1. Time specimen was removed from the patient: Time specimen was placed in formalin Ischemic time: 22 minutes C. The specimen is labeled "RIGHr TOTAL MASTECrOMY " and is received in formalin. (The specimen is in the formalin  more than 6 hours and less than 48 hours). It consist of mastectomy specimen without lymph nodes weighing 990 grams and. measuring 26 x 17 x 6 cm with brown skin ellipse measuring 24 x 12 cm, containing grossly unremarkable 1.5 cm in diameter nipple.. The skin is tagged with a black stitch designating lateral breast. The posterior margin is composed of smooth fascia which is inked black. The breast is sliced in sagittal planes revealing a 2.5 x 2 x 2 cm an ill-defined firm area which is 2.5 cm away from the deep margin of resection. The remaining portions reveal unremarkable yellow mammary fat with streaks of white-gray mammary parenchyma. Representative sections submitted as follows: C1 = nipple C2-C6 -- upper outer quadrant mass C7 =- upper outer quadrant, posterior margin of resection in correspondence of the mass. C8 -- representative section upper inner quadrant C9 -- representative section upper outer quadrant C10 = representative section lower outer quadrant C11 - representative section lower inner quadreant Time specimen was removed from the patient. Time specimen was sectioned and placed in formalin Ischemic time: 15 minutes Dictated by Intra Operative Consultation A. Right breast cores = carcinom? B. Right sentinel node -= no tumor seen Special Stains / Slides Immunohistochemical studies were performed on formalin fixed, paraffin-embedded tissue (Block B1) with adequate positive and negative control sections. Cytokeratins AE1/AE3 and Cam5.2 fail to reveal metastatic carcinoma. The nerfnrmance characteristics of these antibodies were determined by the. ey have not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. I acsc tess are used for clinical purposes. They should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLlA-88) as qualified to perform high-compiexity clinical laboratory testing.. 16 H&E, 4 FS, 16 H&E Page 6 of 7 Print Date/Time
+
+--- Page 7 ---
+MRN: Patient: Sex/DOB:Female Surgical Pathology Report Collected Date/Time: Accession Number: Received Date/Time: Tissue Code 102913 Page 7 of 7 Print Date/Time:
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diff --git a/output/text/689b011a-7c37-4ae3-9050-e03505a38a08.txt b/output/text/689b011a-7c37-4ae3-9050-e03505a38a08.txt
new file mode 100644
index 0000000000000000000000000000000000000000..456f8fe88122b6ca4a4f8ff2805684e6b54b9aae
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+
+--- Page 1 ---
+Accession #: Date of Procedure: Date of Receipt: Date of Report: Account #: Billing Type. Additional Copy to: Ref. Source: TCGABP--5001 Clinical Diaqnosis & History: vith right renal mass Specimens Submitted: 1: KIDNEY, RIGHT; PARTIAL NEPHRECTOMY DIAGNOSIS: KIDney, RIght; PArTIAl NEphrECTOMY Tumor Type: Renal cell carcinoma - Conventionel (cleer cell) type. Fuhrman Nuclear Grade: Nuclear grade II/IV Tumor Size: Greatest diameter is 4.1 cm. Locel Invasion (for renal cortical types): Not Identified Renal Vein invasion: Not identified Small vessel angiolymphatic invasion also not identlfied. Surgical Margins: Free of tumor Non-Neoplastic Kidney: Rere cortical scars Adrenal Glend: Not identified Lymph Nodes: Not identified Steging for renal celi carcinoma/oncocytome: pT1 Tumor <='7.0 cm in greatest dlmension timited to the kldney. H ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWEO AND APPROVED THIS REPORT. Page 1 of 2
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT Gross Description: 1). The specimen is received fresh, lebeled "right renal tumor'.  It consists of a 6.5 to 4.2 x 4.0 cm wedge shaped portion of kidney with a suture marking the deep margin. The margin is inked black and the specimen is serially sectioned to reveal e well-circumscribed yellow mass mieasuring 4.1 x 4.0 x 3.5 cm. The clearance from the resection mergin is 0.1 cm.  A representative section of the nearest margin is submitted for frozen section diagnosis. Representatively submitted. Portions of the tumor are submitted for TPS, Summary of sections: FSC - frozen seclion control T - tumor M - margin RS - representative sections Summary of Sections: Part 1: KIDney, RIGhT; PARTIAl. NEphreCTOmY Block Sect. Site PCs 1 fsc 1 3 m 3 2 rs 3 t 3 Intraoperative Consultatiou: Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intreoperative consullation. 1. FROZEN SECTION DIAGNOSIS: RENAL CORTICAL NEOPLASM. MARGINS (INKED) ARE FREE OF TUMOR. PERMANENT DIAGNOSIS: SAME Page 2 of 2 END OF REPORT
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diff --git a/output/text/689dc817-4676-4ab8-84a9-09a4eea07216.txt b/output/text/689dc817-4676-4ab8-84a9-09a4eea07216.txt
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index 0000000000000000000000000000000000000000..31ab6111c88a3c08507b4a19d8dcc42189446695
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+
+--- Page 1 ---
+Case # Patient: Age (years): Gender:  Male Clinical diagnosis: Anaplastic Squamous cell carcinoma of the esophagus Date of procurement: Sample:histology # Gross description: Esophageal fragment with gastric 25x20x20. Section reveals gray tumor mass 1 cm in thickness. Paraesophageal lymphatic node 1,5x0,4 cm with dark-red surface Microscopic description: Sections reveal ulcerative infiltrated tumor, anaplastic squamous cell carcinoma with heavy lymphoid infiltration. Surgical borders are clear. Paraesophageal lymphatic node shows metastatic cells Paragastric lymphatic nodes and greater omentum show no sign of metastasis Final diagnosis: Anaplastic Squamous cell carcinoma of the esophagus. siuonia, ancplestis,sguamsuscesl. 80Qi|3) O(8o70J3) Code t hiyhest 8070/B Cosfshagus,cistsl thuol c15 5 ephaquw NoS C159  4/Qa|14 Oniy, puH prwnd if0f14 lw 418/!Y Confidential
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diff --git a/output/text/68d04db9-3501-4be8-b5cd-f9170b06c27a.txt b/output/text/68d04db9-3501-4be8-b5cd-f9170b06c27a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..248742bb98cb5adb2615d2e016572927e61a208f
--- /dev/null
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+
+--- Page 1 ---
+Surgical Date: Gross Description: Lymph node is enlarged with 1.5x1x1cm in size, soft, dark brown and gray surface Microscopic Description: Tumor architectures are replaced by diffuse pattern. The tumor cells are composed of small or enlarged transformed lymphoid cells with irregular hyperchromatic nuclei .Tumor cells are oval or round in shape with scant cytoplasm. Nucleoli is single or multiple. Mitotic figures are commnon. Diagnosis Details: Malignant lymphoma, large B cell, diffuse type. Comments:e Formatted Path Reports: Diagnosis: Diffuse large B-cell lymphoma Tumor location: Lymph node, cervical -0-3 Tumor size: 1.5 x 1x 1cm Hese ! Laig Beell 968013 Tumor markers: CD20(+), CD3(-) ymph ncde,Cervicol C77.0 dJ3 UUID: E2645414-D707-419D-B43D-92AE9D56DCD1 TCGA-FA-A6HO-01A-PR Redacted
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diff --git a/output/text/68d88e7b-435c-49fe-b841-f955823c7c87.txt b/output/text/68d88e7b-435c-49fe-b841-f955823c7c87.txt
new file mode 100644
index 0000000000000000000000000000000000000000..bbc3290277b1eba17ad85e27cade72ef5f562eb8
--- /dev/null
+++ b/output/text/68d88e7b-435c-49fe-b841-f955823c7c87.txt
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+
+--- Page 1 ---
+Clinical Diagnosis & History:. y/o femala with left breast ductal CA. UUID:44527CD3-6EC3-4861-8394-CEA005A17A9E Specimens Submitted:. TCGA-AO-A03N-01A-PR : SP: Sentinel node #1, level 1, left axilla (fs). Redacted 2: SP Sentinel node #2, level 1, left axilla (fs). 3: SP Sentinel node #3, level 1, left axilla (fs). 4: SP Sentinel node #4. level 1, left axilla (fs). 5: Sp: Left breast. 6: SP:  Sentinel node #5, level 1, left axilla 7 : SP: I Left axillary contents, levels 1 and 2 (. 8: sP: Left subscapular nodes DIAGNOSIS: 1) LYMPH NODE, SENTINEL #1. LEVEL I, LEFT AXILLA; EXCISION: - METASTATIC CARCINOMA INVOLVING ONE OUT OF ONE LYMPH NODE (1/1). - THE METASTATIC FOCUS MEASURES 2 MM. - NO EXTRANODAL EXTENSION IS SEEN. 2) LYMPH NODE, SENTINEL #2. LEVEL I, LEFT AXILLA; EXCISION: - ONE BENIGN LYMPH NODE (O/1). 3) LYMPH NODE, SENTINEL #3, LEVEL I, LEFT AXILLA; EXCISION: - ONE BENIGN LYMPH NODE (O/1).) 4) LYMPH NODE, SENTINEL #4, LEVEL I, LEFT AXILLA; EXCISION: - METASTATIC CARCINOMA INVOLVING ONE OUT OF ONE LYMPH NODE IN THE FORM OF A SINGLE CLUSTER IDENTIFIED IN A H/E STAINED SECTION (1/1). 5) BREAST, LEFT; MASTECTOMY:S - INVASIVE DUCTAL CARCINOMA, NOS TYPE, HISTOLOGIC GRADE III/III (SLIGHT) OR NO TUBULE FORMATION), NUCLEAR GRADE III/III (MARKED VARIATION IN SIZE AND SHAPE). MEASURING 2.5 CM IN LARGEST DIMENSION GROSSLY (AT LEAST 2.3 CM MICROSCOPICALLY).S - DUCTAL CARCINOMA IN SITU (DCIS) IS ALSO IDENTIFIED, SOLID AND CRIBRIFORM TYPES WITH INTERMEDIATE NUCLEAR GRADE AND MINIMAL NECROSIS. - THE DCIS CONSTITUTES <- 25% OF THE TOTAL TUMOR MASS, AND IS PRESENT ADMIXED WITH THE INVASIVE COMPONENT. - FOCAL LOBULAR CARCINOMA IN SITU (LCIS) IS ALSO IDENTIFIED, CLASSICAL TYPE ** Continued on next page ** ics-0-3 sarckoma iifi/tratny duct, Ncs 85oc/3 Sifu : hraot, Nos. c50.9 lw 10/21/4
+
+--- Page 2 ---
+(TYPE A). - THE INVASIVE CARCINOMA IS LOCATED IN THE UPPER OUTER QUADRANT AND UPPER INNER QUADRANT.S  THE DCIS I3 LOCATED IN THE UPPER OUTER QUADRANT AND UPPER INNER QUADRANT. - NO INVOLVEMENT OF THE NIPPLE BY EITHER IN SITU OR INVASIVE CARCINOMA IS IDENTIFIED.  CALCIFICATIONS ARE PRESENT IN THE IN SITU CARCINOMA AND IN BENIGN BREAST PARENCHYMA.S - VASCULAR INVASION IS PRESENT.S - NO INVOLVEMENT OF THE SURGICAL MARGINS BY BITHER INVASIVE OR IN SITU CARCINOMA IS IDENTIFIED.S - NO SKIN INVOLVEMENT BY CARCINOMA IS IDENTIPIED. - THE NON-NEOPLASTIC BREAST TISSUE SHOWS BIOPSY SITE CHANGES AND INTRADUCTAL PAPILLOMA WITH ATYPIA. - RESULTS OF SPECIAL STUDIES (ER, PR, HER2-NEU) WILL BE REPORTED AS AN ADDENDUM. 6) LYMPH NODES, SENTINEL #5, LEVEL I, LEFT AXILLA; EXCISION: -TWO BENIGN LYMPH NODES (0/2). 7) LYMPH NODES, LEFT AXILLA, LEVEL I AND II; EXCISION: LEVEL I: ELEVEN BENIGN LYMPH NODES (0/11). LEVEL II: ONE BENIGN LYMPH NODE (O/1). 8) LYMPH NODE, LEPT SUBCAPSULAR; EXCISION: - ONE BENIGN LYMPH NODE (O/1). I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL). AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT.S *** Report Electronically Signed Out *** Special Studies: Result Special Stain Comwnent ER-C pR-C HER2-C NEG-HER2 NEG CONT IMM RECUT Qrnaa nescription: M.d. M.d. 1). The specimen is received fresh for frozen section consultation, labeled "sentinel node number 1, level 1 left axilla" and consists of one lymph node measuring 2.5 x 1.2 x 1.0 cm. Entirely submitted for frozen section (bisected). ** Continued on next page *
+
+--- Page 3 ---
+Sunmary of sections: FSA-rss .- frozen section control M.D.  The specimen is received fresh for frozen section consultation, labeled "sentinel node number 2, level 1 left axilla" and consists of one lymph node measuring 1.2 x 0.5 x 0.5 cm. Entirely submitted for frozen section.. Summary of sections: Fsc --  frozen section control M.D. 3). The specimen is received fresh for frozen section consultation, labeled "sentinel node number 3, level 1 left axilla" and consists of one lymph node measuring 1.2 x 0.5 x 0.5 cm. Entirely submitted for frozen section. Summary of sections: Fsc -- frozen section control M.D. 4). The specimen is received fresh for frozen section consultation, labeled "Sentinel node number four, level one, left axilla" and consists of one. lymph node measuring 0.9 x 0.4 x 0.4 cm. entirely submitted for frozen section diagnosis.  The lymph node is bisected and Summary sections: FSC -- frozen section control ,M.D. 5) The specimen is received fresh, labeled Left breast" and consists of a breast measuring 21.5 x 14.0 x 3.4 cm with an overlying skin ellipse measuring 10.8 x 5.0 cm. Situated centrally on the skin surface is an everted nipple measuring 1.3 x 1.3 x 0.6 cm and areola measuring 2.2 x 2.2 cm. A suture demarcates the axillary aspect. The posterior surface of the breast is inked black, the anterior aspect is blue and the axillary aspect green and the specimen is serially sectioned to reveal an indurated tan-white tumor measuring 2.5 x 2.4 x 2.3 cm, the upper outer quadrant, between 12 o' clock and one o' clock, focally.  and located predominantly in extending into the upper inner quadrant, 0.2 cm from the anterior aspect and 0.7 cm from the deep margin.  Sectioning of the axillary aspect reveals no grossly identifiable lymph nodes. Tissue is submitted for TpS. Representative sections are submitted. Sumnary of sections: N - nipple Continued on next page **
+
+--- Page 4 ---
+ NB - nipple base T - tumor TAm,TDm-tumor to anterior aspect and deep margin respectively UIQ LIQ lower inner quadrant UOQ - upper outer quadrant LOQ  lower outer quadrant P.A 6). The specimen is received in formalin, labeled nSentinel node, number five, level one, left axilla" and consists of two single pink-tan firm lymph nodes measuring 0.9 x 0.6 x 0.3 and 1.4 x 0.8 x 0.6 cm. Summary of sections: BLN  bisected lymph nodes P.A. 7). The specimen is received in formalin, labeled "Left axillary contents one and two tags attached". It consists of a 7 x 4 x 3 cm fragment of fibroadipose tissue. Two tags are present, designating levels 1 and 2. Multiple lymph nodes are identified, ranging in size from 0.9 cm to 2.7 cm. All identified lymph nodes are submitted. Summary of sections: L1LN - level one lymph nodes L1BLN-level one bisected lynph nodes L2BLN-level two bisected lymph nodes P.A. 8). The specimen is received in formalin, labeled "Left sub-scapular node" and consists of a single pink-tan, fatty lymph node measuring 0.3 x 0.2 x 0.2 cm. The lymph node is entirely submitted. Summary of sections: LN- lymph node Summary of Sections: ** Continued on next page **
+
+--- Page 5 ---
+Part 1: SP: Sentinel node #1 left axilla (fs) Block Sect. site PCs fsa fsb Part2 SP: Sentinel node #2, level 1, left axilla (fs) Block Sect. site pCs 1 fsc 1 Part 3: SP: Sentinel node #3, level 1,  left axilla (fs) Block Sect. site pCs 1 fsc 1 Part 4: SP: Sentinel node #4, level 1, left axilla (fs) Block Sect. Site pCs 1 fsc 1 Part 5: SP: Left breast Block Sect. Site pCs 22 1iq 2 2 loq 1 n 1 nb 4 1 t tam 1 1 tdm 12 uiq uoq 2 Part 6: SP: Sentinel node #5, level 1, left axilla Block Sect. Site pCs 2 BLN Part 7:  SP: Left axillary contents, levels 1 and 2 Block Sect. Site PCs L1BLN LILN 8 4 L2BLN 2 Part 8: SP: Left subscapular nodes Block Sect. Site PCs LN 1 Procedures/Addenda: Addendum Continued on next page **.
+
+--- Page 6 ---
+Date Ordered: Status: Sianed Out Date Complete: Date Reported: By: MD Addendum Diagnosis ADDENDUM REPORT SITE: LEFT BREAST (PART #5) ER: 7O% NUCLEAR STAINING WITH MODERATE TO STRONG INTENSITYS PR: 3% NUCLEAR STAINING WITH WEAK INTENSITYS HER2/NEU(HERCEPTEST) : NEGATIVE (STAINING INTENSITY OF 0) Intraoperative Consultation: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 1A,B) FROZEN SECTION DIAGNOSIS: METASTATIC CARCINOMA. PERMANENT DIAGNOSIS: SAME. 2) FROZEN SECTION DIAGNOSIS: BENIGN LYMPH NODES. PERMANENT DIAGNOSIS: SAME. 3) FROZEN SECTION DIAGNOSIS: BENIGN LYMPH NODES. PERMANENT DIAGNOSIS: SAME . 4) FROZEN SECTION DIAGNOSIS: BENIGN LYMPH NODE. PERMANENT DIAGNOSIS: SAME. MD ** End of Report **
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diff --git a/output/text/6905f8c4-bbda-4c14-be5a-b0858a47a6f3.txt b/output/text/6905f8c4-bbda-4c14-be5a-b0858a47a6f3.txt
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index 0000000000000000000000000000000000000000..6ad8ebdfe14b8b3b37de25ca6f9ce1e8c1ac8c6a
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+
+--- Page 1 ---
+UUID:34F6C188-BEEA-4286-SF31-5A3E351C6AA7 TCGA-A4-A4ZT-01A-PR Redacted Gender:F Date of Service: Date Received: FINAL SURGICAL PATHOLOGY REPORT Diagnosis: Kidney, Left, nephrectomy: - PAPILLARY RENAL CELL CARCINOMA, SEE COMMENT. - FUHRMAN NUCLEAR GRADE 3 /c -0- 3 - tumor size: 6 cm. - LImIted To kIdney. carciomn, Prpillsry Renul cill - SURGICAL MARGINS NEGATIVE. 83t0/3 Sif: Kidny,nrs cc4.9 PATHOLOGIC TUMOR STAGING SYNOPSIS (LEFT KIDNEY): Type and grade: Papillary renal cell carcinoma, Fuhrman nuclear grade 3. Primary tumor: pT1b. Regional Iymph node: pNX. Distant metastasis: N/A. Pathologic stage: I. Lymphovascular invasion: Not identified. Margin status: Ro, negative. COMMENT: Sections of the tumor show a papillary renal cell carcinoma with a predominantly type I histologic pattern with Fuhrman nuclear grade 1 nuclei, however, there are focal areas with Fuhrman grade 3 nuclei with a type ll architectural pattern. Kidney Tumor Staging Information. Data derived from current specimen. Staging in accordance with or modified from AJCC Cancer Staging Handbook, 7th Ed, and CAP protocol, June 2012. Page 1 This report continues... (FINAL). Patient Name - Pathology Report - Page 1/3. Job ige 1 Doc# 1
+
+--- Page 2 ---
+Case #: Radical nephrectomy. Procedure: Left. Specimen laterality: TUMOR FEATURES: 6 cm. Tumor size: Single focus. Tumor focality: Limited to kidney. Macroscopic extent ot tumor: Papillary renal cell carcinoma.. Histologic type: Not identified. Sarcomatoid features: Fuhrman nuclear grade 3. Histologic grade: Limited to kidney. Microscopic tumor extension:. RO, negative. MARGINS: Not identified. LYMPH NODES:  PATHOLOGIC STAGING: pT1b. Primary tumor: pNX. Regional lymph nodes: N/A. Distant metastasis: I. Pathologic stage: Interstitial chronic inflammation.. Pathologic findings in non-neoplastic kidney: Source of Specimen: Page 2 This report continues... (FINAL) - Page 2 Doc# 1 Pathology Report .
+
+--- Page 3 ---
+Patient: Case # FInAL SURGICAL PAThOLOgy REPORT Kidney;Lelt Clinical History/Operative Dx: Renal mass Gross Description:. The specimen is labeled left kidney and is received without fixative. It consists of a nephrectomy specimen which together perinephric fat weighs 627 grams. It measures 20 cm from superior to inferior, 10 cm from medial to lateral, and 9 cm from anterior to posterior. Along the anterior surface there is lobulated fatty tissue and there is a bulging fluctuant mass at the inferior pole of the kidney. At the hilum the renal artery and renal vein are identified. The vessels are opened and show no gross evidence of intraluminal tumor. Extending from the hilum of the kidney there is an 8 cm segment of ureter which appears somewhat attenuated. The ureter is opened to reveal smooth tan-white urothelium. The kidney is bivalved to reveal a fluid filled cystic mass in the inferior pole which bulges anteriorly this cystic mass measures 6 x 6 x 5.2 cm. It contains amorphous brown material and turbid fluid. The lining of the cyst is brown with patchy srnall areas of yellow discoloration. The cyst is 1.3 cm from the hilum of the kidney. It appears contained within the renal capsule and is separated from the anterior surface of the kidney by a thin layer of smooth fascial tissue. Representative sections of the mass are obtained for research purposes. The remaining.  kidney has pale red parenchyma and normal appearing medullary rays. Cortical thickness is 0.6 cm. There are scattered fluid filled cysts within the cortical portion of the kidney which are up to 1.3 cm. No other discrete masses are present. Serial sections of the perineural adipose tissue reveal no grossly obvious. Iymph nodes and no identifiable adrenal tissue. Representative sections are submitted. Section summary: A1) surgical margin, renal artery, renal vein and ureter, A2) additional sections of ureter and ureteral pelvic junction, A3) anterior surface of lower pole kidney including possible Gerota's fascia, A4-A6) additional representative sections of cyst. A7) cyst and closest approach to hilum, A8) uninvolved kidney. Microscopic Description:.  Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered. An intradepartmental consultation witr office notified of resul Page 3 END OF REPORT (FINAL) MR No. Patient Na Pathology Report - Page 3/3 - Page 3 Doc# 1
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diff --git a/output/text/6916712f-be4d-4c4e-9ea2-b5db0ffec839.txt b/output/text/6916712f-be4d-4c4e-9ea2-b5db0ffec839.txt
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index 0000000000000000000000000000000000000000..b66227bbcec0752b1b90fdc4bf5cf4f04fb64759
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+
+--- Page 1 ---
+RUN DATE:  PAGE 1 RUN TIME: RUN USER: PATIENT: ACCT #: LOCr AGE/SX ROOM REG DR REG DOB: BED: DIS: STATUS: SPEC #: UUID:C3BD485F-0FB9-4B22-B8FE-9D68966085E9 TCGA-LL-A50Y-01A-PR Redacted CLINICAL INFORMATION: Pre-Op Diagnosis: Right breast Iobular CA. Remarks: Specimen(s) : A. Left breast tissue - stitch marks axillary tail. B. Right modified radical mastectomy - stitch marks axillary contents. LEFT BREAST TISSUE, TOTAL MASTECTOMY WITH TWO AXILLARY LYMPH NODES: INTRADUCTAL PAPILLOMA WITH ATYPICAL HYPERPLASIA, SUBAREOLAR, SMALL FOCI OF LOBULAR CARCINOMA IN SITU FIBROCYSTIC CHANGES TWO LYMPH NODES, NO PATHOLOGIC. DIAGNOSISS RIGHT BREAST, MODIFIED RADICAL MASTECTOMY: MULTIFOCAL INVASIVE LOBULAR CARCINOMA (AT LEAST 4 FOCI DETECTED) LARGEST FOCUS OF INVASIVE LOBULAR CARCINOMA MEASURES 3 CM IN GREATEST DIMENSION (pT2) NOTTINGHAM COMBINED HISTOLOGIC GRADE 2 OF 3S TUBULE FORMATION SCORE 3 OF 3 NUCLEAR PLEOMORPHISM SCORE 2 OF 3 MITOTIC RATE SCORE 1 OF 3 DUCTAL CARCINOMA IN SITU NOT IDENTIFIED SURGICAL MARGINS OF RESECTION FREE OF INVASIVE CARCINOMA WITH CLOSEST MARGIN MEDIAL MARGIN APPROXIMATELY 1 MM EIGHT AXILLARY LYMPH NODES, NO PATHOLOGIC DIAGNOSIS (NO EVIDENCE OF METASTATIC CARCINOMA) SEE COMMENT FOR SURGICAL PATHOLOGY CANCER CASE SUMMARY CHECKLIST 1cd-0-3 carcinona, nifiItratny kbulw, NoS 8520/3 COMMENT(S) Site: brst, nos c50.9 SURGICAL PATHOLOGY CANCER CASE SUMMARY - CAP APPROVED Procedure: Total mastectomy (includirg nipple and skin). Lymph Node Sampling: Axillary dissection (partial or complete dissection) Specimen Laterality: Right Tumor Site: Other; multifocal Histologic Type: Invasive lobular carcinoma. Tumor size: Greatest dimension of largest focus of invasion. ** CONTINUED ON NEXT PAGE **
+
+--- Page 2 ---
+PAGE 2 RUN DATE RUN TIME: RUN USER: (Continued) SPEC #: PATIENT: COMMENT(S) (Continued) >1 mm: 3Q mm (3.0 cm) Histologic Grade: Glandular/Tubular Differentiation: Score 3 Nuclear Pleomorphism: Score 2 Mitotic Rate: Score 1 Overall Grade: Grade 2 Tumor Focality: Multiple foci of invasive carcinoma: 4 foci. Ductal Carcinoma In Situ:. No DcIs is present Invasive Carcinoma: Margins uninvolved by invasive Margins: carcinoma. Distance from closest margin: 1 mm; medial DcIs: Dcrs is not present. Lymph Nodes: Number of sentinel lymph nodes examined: 0. Total number of lymph nodes examined (sentinel and nonsentinel): 8 Number of lymph nodes with macrometastases (>2 mm): Number of lymph nodes with micrometastases (>0.2 mm. to 2 mm and/or >200 cells): 0 Number of lymph nodes with isolated tumor cells (<0.2 mm and <200 ce1ls): 0 Number of lymph nodes without tumor cells identified: 8 Lymph-Vascular Invasion: Not identified Not identified Dermal Lymph-vascular Invasion: Pathologic Staging: TNM Descriptors: m Primary Tumor: pT2 Regional Lymph Nodes: pNO Distant Metastasis; Not applicable.. Ancillary Studies: ER: Positive (loot of tumor cells with nuclear positivity); Strong PR: Positive (ioot of tumor cells with nuclear positivity); Moderate HER2 Immunoperoxidase Stains: Equivocal (Score 2+) GROSS DESCRIPTION: Specimen A is received in the fresh state labeled *left breast tissue". This is a breast The skin measures 24 x 15 cm. The. with an overlying ellipse of white skin and nipple.. skin and nipple are unremarkable. The breast measures 24 x 15 x 4 cm. A suture tags the axillary tail which measures 5 x 3 x 3 cm. The chest wall margin is fatty and. unremarkable. This margin is marked with black ink. The specimen is serially sectioned. The breast tissue is mostly fatty without focal suspicious lesions. A couple of large fatty lymph nodes are found in the axillary tail with the largest one measuring 3 cm in greatest dimension.  Representative sections are submitted as follows: A1 nipple A2-5 - representative breast tissue moving medial to lateral A6 chest wall margin, inked. ** CONTINUED ON NEXT PAGE **
+
+--- Page 3 ---
+RUN DATE: PAGE 3 RUN TIME:  RUN USER: SPEC # (Continued) GROSS DESCRIPTION: (Continued) A7 axillary tail A8 one fatty lymph node A9-11- largest fatty lymph node. Specimen B is received in the fresh state labeled "right modified radical mastectomy". This is a breast with an overlying ellipse of white skin and nipple. The skin ellipse measures 20 x.15 cm. The breast measures 20 x 15 x 4 cm. The axillary tail measures 8 x 8 x 3 cm. The skin and nipple are unremarkable. The chest all margin is fatty without focal lesions.  The chest wall margin is inked black. There is some palpable nodularity along the medial most margin and this margin is inked blue. Serial sections through the breast reveal mostly fatty tissue with irregular areas of white fibrosis. In the central breast roughly 3 cm inferior to the nipple is an ill-defined, indurated area suspicious for tumor and associated with fresh hemorrhage. This area spans approximately 1 cm by palpation and a portion of this area is submitted for tumor banking, handed off to There appears to be a separate tumorous area in the lateral breast roughly 6 cm from the nipple and spanning by palpation roughly 3 cm. Again, this area is visually ill-defined. may be: yet a third ill-defined indurated area in the far lateral breast spanning  There approximately 7 mm.  Several fatty lymph nodes. are identified in the axillary tail. These measure up to 3 cm in greatest dimension. Representative sections are submitted as follows: B1,2 - nodularity in the medial most breast B3 nipple B4 grossly uninvolved medial breast tissue B5-7 1 cm nodule mid inferior breast B8. hemorrhagic focus mid breast. B9 chest wall margin central breast B10-12- 3 cm area of nodularity lateral breast B13 possible third area of nodularity lateral breast B14,15- one fatty lymph node B16 one fatty lymph node B17,18- one fatty lymph node B19;20-  multiple lymph nodes Note: The specimen margins were grossly uninvolved by tumorous tissue by at least.1 cm along the deep margin.. MECROSCOPIC DESCRIPTION:S The slides are examined and evaluated. E-cadherin stain is performed on the left breast tissue in an area showing features of lobular carcinoma in situ and atypical lobular hyperplasia. The E. Cadherin stain is negative confirming this diagnosis. In addition to the histologic sections one of the lymph node from the right modified radical mastectomy is examined with Pankeratin stain. No evidence of metastatic carcinoma is detected either in the histology or the Pankeratin stain. ** CONTINUED ON NEXT PAGE **
+
+--- Page 4 ---
+PAGE 4 RUN DATE RUN TIME RUN USER: PCI User: (Continued) PATIENT: SPEC INTRAOPERATIVE CONSULTATION: B. RIGHT MODIFIED MASTECTOMY, GROSS EXAM: MARGINS INKED TUMOROUS TISSUE HANDED OFF TO TUMOR BANKING
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diff --git a/output/text/6921bbaa-2b37-4b66-bb24-d6f9dd837429.txt b/output/text/6921bbaa-2b37-4b66-bb24-d6f9dd837429.txt
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index 0000000000000000000000000000000000000000..a1680dfbaec3206021769d42782472f042e8c2dd
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+
+--- Page 1 ---
+COPY TO: Operative Consult: "Pill cam present in terminal ileum, no FS, reported to Dr. 1 positive patient ID" Pre-Op Diagnosis. Obstructing right colon cancer Post-Op Diagnosis. Same Clinical History Nothing indicated on requisition Gross Description:. Container labeled '. - right colon" is a 27.5 cm. previously opened portion of partially sectioned large bowel including cecum as well as 9.5 cm of attached previously opened slightly dilated termina! ileum. The specimen is covered by a moderate amount of pericolic, epipioic, and omental adipose tissue with a few fibrous adhesions which kink the large bowel immediately distal to the cecum. The serosa is shaggy and gray tan to pink. The small bowel wall is up to 0.6 cm and fibrotic. The lumen is lined by gray tan mucosa with preservation of intestinal folds and. slight granularity; however, no gross lesions are identified. The large bowel wall is up to 0.6 cm, edematous, and fibrotic. The Iumen is lined by gray tan mucosa with preservation of intestinal folds. Extending from the ileocecal valve into the cecal pouch is a. previously sectioned markedly distorted centrally ulcerated finely granular gray red to brown lesion measuring on reconstruction approximately 7.5 x 5.5 cm. This markedly stenoses the lumen in the area of the ileocecal vaive which in one area on reconstruction measures less than 0.8 cm in diameter. The lesion does not extend. to the appendiceal orifice. Within the adipose tissue is a 6.6 x 0.8 x 0.8 cm grossly unremarkable vermiform appendix. The lesion has a gritty focally necrotic tan gray fibrotic cut surface and
+
+--- Page 2 ---
+grossly extends up to 1.6 cm in thickness. In most areas this extends to but not through the serosa predominantly in the area of the cecal pouch; however, in one area this grossly appears to focally extend into the surrounding adipose tissue where it is seen at its nearest point 1.0 cm from the nearest soft tissue margin. The specimen is received after operative consult which is reported as "pill cam present in termina! ileum, no FS, reported to Dr.  positive patient ID" by Dr.  Separately received in the specimen container is a 2.8 x 1.2 x 1.2 cm capsular portion of foreign plastic material which one half is a transparent lens. On one side this is labeled "pill cam." Additionally noted. within the snecimen container are three tissue cassettes each. labeled " Sectioning the surrounding adipose tissue shows severa! poorly defined gray yellow nodules up to 1.0 cm. Representative sections are submitted labeled as follows: A - proximal margin, B - distal margin, C - representative small bowel, D through G - representative lesion and surrounding tissue, H - random uninvolved bowel, I - appendix, J through L - nodules fro pericolic fat. Microscopic Description: The slides labeled  are examined. See diagnosis.. Final Diagnosis Terminal ileum, appendix, and right colon (right hemicolectomy) Terminal ileum: No carcinoma identified.  PAS 1 Appendix: No carcinoma identified. PAS 1 Colon: Tumor characteristics: Histologic type: Adenocarcinoma. Location of tumor: Cecum. Size: 7.5 x 5.5 x 1.6 cm in greatest dimension. Grade: Moderately differentiated.. Lymphovascular space invasion: No unequivocal lymphovascular space invasion identified. Perforation of Viscerai peritoneum: No.. Presence of mesenteric deposits: No. Depth of invasion: Carcinoma extends through muscularis propria into subserosal adipose tissue within less than 1 mm of the serosal surface but no perforation identified grossly or microscopically (see comment).. Surgical Margin Status: Proximal Margin: No carcinoma identified. Distal Margin: No carcinoma identified. Deep Radial Margin: No carcinoma identified. Distance of tumor from closet margin: Carcinoma extends to. within less than 1 mm of the serosal surface but no clear perforation identified. Lymph Node Status: Total number of lymph nodes examined: 19 Total number of lymph nodes with metastatic carcinoma: 0 (0/19) PAS 9 Other: Stenosis associated with tumor. PAS 3. Fibrous serosal adhesions. PAS 4 Grossly noted pill cam present within specimen. PAS 2 SPC-A CPT: 88309 x1, 88329 x1
+
+--- Page 3 ---
+Stage: pT3N0 Comments The carcinoma extends through muscularis propria into subserosal adipose tissue. Microscopically, the carcinoma extends to within less than 1 mm of the serosal surface but is not clearly perforated. Clinical correlation and follow up is recommended. At the request of the undersigned pathologist, these slides have been additionally reviewed by who concurs with the diagnosis. <Sign Out Dr. Signature>
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diff --git a/output/text/6935f07f-b44a-48cc-a39a-efd4f5b33790.txt b/output/text/6935f07f-b44a-48cc-a39a-efd4f5b33790.txt
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+Examination: Histopathological examination - Material: Multiple organ resection - segment of the large intestine. TCGA-D5-5539 Material collected on Material received on: Clinical diagnosis: tumour of the ascending colon, right half of the large intestine with the distal segment of the ileum. Examination performed on:. Macroscopic description:.  20 cm length of the large intestine, with periintestinal tissue sized 23 x 11 x 3cm, 13.8 cm segment of the smal! intestine, and a 6 cm appendix. Ulcerous tumour found in the mucosa, sized 3.3 x 5.2 x 0.8 cm. The lesion surrounding 60% of the Intestine circumference, placed 15.3 cm from the proximal cut end, 15.0 cm from the distal cut end, and 1.4 cm from the ileocecal valve. Tumour accompanied by polyps of up to 2.0 cm in diameter. Microscopic description:. Adenocarcinoma tubulare et mucinosum (G3).. Infiltratio carcinomatosa telae adiposae pericolicae Intestine ends free of neoplastic lesions.. Apart from the tumour: Adenoma tubulopapillare cum dysplasia minoris.. metastases carcinomatosae in lymphonodo (No I / IV ).. Histopathological diagnosis:. Adenocarcinoma tubulare et mucinosum coli.. Metastases carcinomatosae in lymphonodo (No I / IV ).. (G3, Dukes C, Astler-Colier C2, pT3, pN1) TvRVlAR sN> NWQNVS kI>ENOARCNOMA CF THE cC-CN METASTATc lYHPH NASE C1/V ompirance validated b.
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diff --git a/output/text/693fa391-42af-44b4-851a-4df3e457be2b.txt b/output/text/693fa391-42af-44b4-851a-4df3e457be2b.txt
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index 0000000000000000000000000000000000000000..6c31a2ac8a7d712782ef5fc130c813cb87082254
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+--- Page 1 ---
+.c. FINAL DIAGNOSIS: Part 1: sentinel lymph node number 1, Left, biopsy - ONe Of tHree Lymph nODeS, POsItivE fOR MetaStaTic LOBulAR CARciNOmA (1/3). B.  METASTATIC TUMOR MEASURES 1.4 CM iN LARGEST DIMENSION. C.  NO DEFINITE EXTRACAPSULAR EXTENSION IDENTIFIED. Part 2: BreaSt, LEft;mODIfIed rADical mAstectOmy - A.  MULTIFOCAL ND MULTICENTRIC iNVASIVE LOBULAR CARCINOMA, NOT TINGHAM GRADE 2 (TUBULAR FORmatiOn 3, nUCLEAR POlymORPhISm 2, mITOtiC fIgUreS T, TOtal SCORE 6/9). B. INVASIVE TUMOR MASS RANGING IN SIZE FROM 1.5 TO 2.7 CM; THE LARGEST TUMOR MASS MEASURING 2.7 CM IN LARGEST DIMENSION (GROSS MEASUREMENT). C. INVASIVE LOBULAR CARCINOMA INVOLVES ALL FOUR QUADRANTS. D.  LOBULAR CARCINOMA IN SITU, nUCLEAR GRADE 2, CONSTiTUTING 25% OF TOTAL TUmOR MASS, ADMIXED AND AWAY FROM THE INVASIVE COMPONENT. E. NO LYMPHOVASCULAR INVASION IDENTIFIED F. DEEP RESECTION MARGIN iS POSITIVE FOR INVASIVE LOBULAR CARCINOMA IN LOWER iNNER QUADRANT (SLiDE 2F). G. FIVE OF TWENTY-ONE AXILLARY LYMPH NODES POSITIVE FOR METASTATIC LOBULAR CARCINOMA (5/21). H.  METASTATIC TUMOR MEASURES 0.8 CM IN LARGEST DIMENSION AND WITH FOCAL EXTRACAPSULAR EXTENSION. 1 NIPpLE ShOWING LOBULAR CARCInOmA IN SITU WIth DUCtAL EXTenSIOn, 5 Mm TO tHE SKIN SURFACE (SLIDE 2A). J. BIOPSY SITE CHANGES. K. FIBROCYSTIC CHANGE WITH DUCTAL EPITHELIAL HYPERPLASIA. JCD-0-3 LATERALITY: LCIt Cancnma mnifilratuy 1obulew, nrs 8520|3 PROCEDURE: Modified radical mastectomy Upper outer quadrant Sih: brstNts C5o.9 3/131u h LOCATION: Upper inner quadrant Lower outer quadrant. Lower inner quadrant SIZE OF TUMOR:  Maximum dimension invasive component: 2.7 cm MULTICENTRICITYIMULTIFOCALITY OF INVASIVE FOCI: Yes TUMOR AGGREGATE SIZE: Sum of the sizes of multiple invasive tumors: 7.9 cm TUMOR TYPE (invasive component): Infiltrating lobular carcinoma HISTOLOgIC Type: Classicai UUID:F44C515D-5A58-4382-A147-4429A78D434F Redacted  NOTTINGHAM SCORE: Nuclear grade: 2 TCGA-BH-A0B5-01A-PR Tubule formation: 3 Mitotic activity score: 1 Total Nottingham score: 6 Nottingham grade (1, 2, 3): 2 ANGIOLYMPHATIC INVASION: No DERMAL LYMPHATIC INVASION: No CALCIFICATION: No Tumor type, in situ: LCIS SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: Yes, focal LYMPH NODES POSITIVE: 6 LYMPH NODES EXAMINED:S 24 mEtHOD(S) OF LymPh nODE EXAMiNATION: H/E stain SENTINEL NODE METASTASIS: Yes SIZE OF NODAL METASTASES: Diameter of largest lymph node metastasis: 14 mm LYMPH NODE METASTASIS(-ES) WiTH EXTRACAPSULAR EXTENSION: Yes NON-NEOPLASTIC BREAST TISSUE: FCD t stage, pathologIC: pT2 N STAGE, PATHOLOGIC:  pN2 M STAGE, PATHOLOGIC: pMX ESTROGEN RECEPTORS: positive prngestFronf rfcfptors nnsitive
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diff --git a/output/text/69599531-7ea3-46e4-bd59-a9e06be0e4cd.txt b/output/text/69599531-7ea3-46e4-bd59-a9e06be0e4cd.txt
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+--- Page 1 ---
+TCGA-CM-4746 Clinical Diagnosis & History: Sigmoid cancer, Specimens Submitted: 1: SP: Sigmoid colon 2 sp: Proximal donut 3: sp: Distal donut DIAGNOSES: 1. LARGE BOWEL, SIGMOID RESECTION: TUMOR TYPE:ADENOCARCINOMA, MODERATELY DIFFERENTIATEIS - TUMOR LOCATION:SIGMOID. TUMOR SIZE: LENGTH IS 4,4 CH, WIDTH IS 3.7 CM. - GROSS CONFIGURATXON: FUNGATING. -.PREEXISTING POLYP (AT THE SITE OF THE CARCINOMA):  IDENTIFIED, OP TUBDLOVILLOUS TYPE, TUMOR INVASION: INVASION INTO MUSCULARIS PROPRIA. GROSS TUMOR PERFORATION: NOT IDENTIFIED -SBROSAL INVOLVEMENT;  NOT IDENTIFIED. -VASCULAR INVASION: NOT IDENTIFIED. -PERINEURAL INVASIONNOT IDENEIFIED, - SURGICAL MARGINS (FOR COLONIC TUMORS); FREE OF TUMOR. POLYPS (AWAY FROM THE CARCINOMA): NUMBER IDENTIFIED: MUL/TIPLE, TYPE IDENTIFIED: HYPERPLASTIC POLYP. TATTOO PIGEMNT IS NOTED INVOLVING MUSCULARIS PROPRIA IN THE AREA ADJACENT TO THE TUMOR, CONSISTENT WITH PRIOR BIOPSY SITE - THE PATHOLOGIC STAGE IS pT2 TUMOR INVADES MUSCOLARIS PROPRIA. .LYMPH NODES: 0, NUMDER EXAMINED: 17 - THE PATHOLOGIC STAGE IS pNO NO REGIONAL LYMPH NODE METASTASES ARE IDENFIFIED. 2. COLON, PROXIMAL DONUT; EXCISION: UNREMARKABLE COLONIC TISSUB, 3. COLON, DISTAL DONUT; EXCISIONt UNREMARKABLE COLONIC TISSUE, Continued on next page
+
+--- Page 2 ---
+ Page 2 of 3 I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. 1.) The apecimen is received freah and in labeled "gigmoid tolon*, It consiats of a segment of colon that measurea 13.8 cm in length by 6.8 cm in cizcumference at proximal resection margin (inked yellow) and 8.0 cn in Circumference at distal resection margin (inked blue). The serosal surface is smooth. The specimen is opened to reveal a pink fungating tumor that is located 4.0 cm from the distal margin and 4.2 cm from proximal margin. The turor measures 4.4 cm in length and 3.7 cm in width. Serial sectioning reveals tumor invasion to a depth of 0.l cm, which is 0.5 cm Erom the gerosa. The remaining mucosa shows at least 16 polyps measuring ftom 0.2 to 0.4 cm in greatest dimension.. Pericolic and peri-rectal adipose tiseue is. thoroughly examined for lymph nodes, and all possible noden are submitted. Representative sections are subnitted. The tunor is entirely submitted. tps submitted. Summary of sections: PM .- proximal margin. DM .-. distal margin T .. tumor  .. uninvolved mucosa polypa LN --" Iymph nodes. 2). The specimen is received in formalin, labeled "proximal donut" and consisto of a ring of pink tan soft tissue measuring 2 x 2 x 1.5 cm. Multiple sutures and ataples are attached.. The mucogal surface is pink tan and focally hemorrhagic. The sutures and staples are removed and the soft tissue is entirely submitted.. Summary of sectiong:. U--undesignated 3). The specimen is received in foxmalin, Iabeled "Distal donut" and consists of a xing of pink tan soft tisgue measuring 2.5 x 2.2 x 1.3 cm. the mucosa is removed and entirely aubmitted. Summary of sections: J-undeaignated +* Continued on next page **
+
+--- Page 3 ---
+Page 3 of 3 Swmmaxy of Sectione: Part 1t SP: Sigmoid colon B1ock Sect, Site PCo dm H w sn r m m In P i y pm m 14 u Paxt 2: Sp: Pxoximal donut Sect. site. rCs Block u 1 Part 3: Sp: Distal donut alock Sect. Site PCB 1 Lt  End of Report
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+
+--- Page 1 ---
+QC Patholc gist: FINAL PATHOLOGIC DIAGNOSIS: Colon, righ';, segmental resection:. Tumor Characteristics: 1. Histologic type: Adenocarcinoma.. 2. Histologic grade: Moderately differentlated. 3. Tumor site: Right colon. 4. Tumor uize: 3.0 x 2.7 x 0.5 cm. 5. Lymphcvascular space invasion: Not identified. 6. Perfora'ion of visceral peritoneum: No.. 7. Presenca of mesenteric deposits: No.'- * 8. Depth cf Invaston: Tumor invades submucosa but not to the muscularis propria. Surgical Margin Status: 1. Proximal margin: Negativee. 2. Distalrargin: Negative.. 3. Deep(radlal) margin: Negative.. 4. Distante of tumor from closest margin: Approximately 1 cm from the inked deep surface. Lymph Node Status: 1. Total number of lymph nodes examined: 22. 2. Total number of lymph nodes containing metastatic. carcinomal: None (0/22) Other: 1. Other significant findings: Tubular adenomas;.  hyperplastic polyp 2. pTNM stage: pT1 NO. COMMENTS: CLINICAI. HISTORY: with right colon Preoperative Diagnosis: cancer Postoperative Diagnosis: Symptor s/Radiologic Findings: SPECIMIENS: Right coton
+
+--- Page 2 ---
+. * PROCEDUFAL DEMOGRAPHICS: +* Date of Procedure! .. ... Accession Date/Ti! GROSS DE'SCRIPTION: The specimun is received in a single formalin filled. . +- ++*+ contalner lal:eled with the patient's name 'right colon' and consists of a right hemicolectomy specimen. comprised cf terminal ileum (4.5 cm in length x 2.0 cm in diameter), cscum/right colon (10.5 cm in length and ranging from 4.5 up to 7.0 cm in diamater), and vermiform'appendix (8.0 cm in kngth and ranging from 0.5 to 0.9 cm in dlameter). The specimen Is received stapled closed at both ends. The serosa is tan-gray, smooth to shaggy with adherent. yellow-tan niesocolonic fat. On opening, the wall averages 0.7 cm in thlckness. Located within the proximal colon is a. 3.0 x 2.7 x 0.5 cm pink-tan fungating mass that approaches to within 6.f cm of both the ileal and colonic margins. On sectlon, this: mass extends to abut the muscularls and approaches. to within 1.0 cm of the inked deep surface.. Discrete mtiscle invasion is not Identified grossly. The remainder of the mucosa is remarkable for multiple pink-tan. polypold lesions ranging from 0.3 up to 1.4 cm in greatest dimension. These approach to within 2.5 cm of the colonic margin and 3.5 cm of the ileal margin. On section, all are confined to the mucosa. The appendix is sectioned to reveal a pinpoint t smen with no perforations or fecaliths. On secton and! palpation, multiple flrm fatty possible lymph nodes are identiied within the associated fat. They range from 0.3 ut to 1.0 cm in greatest dimension. Representative sections are submitted in cassettes 1-14 labeled 713 Breedlove designated as follows: 1, ileal margin, en face; 2, colonic rnargin, en face; 3-5, entire mass to inked deep margin; 6-4-sections.to include whole polypoid lesions; 8, two full thk kness sections to include entire largest polypoid lesion; 9, vermiform appendix; 10-12, five whole possible ly nph nodes in each cassette; 13, four whole possible symph nodes; 14, three whole possible lymph nodes. Additionally, a yellow, green, and blue cassette sre submitted for
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diff --git a/output/text/698dcb29-dca9-4a96-a80c-a6f476d85cd6.txt b/output/text/698dcb29-dca9-4a96-a80c-a6f476d85cd6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..295bfc9923a7d74f0dfb3384719e9d5bde25c8ed
--- /dev/null
+++ b/output/text/698dcb29-dca9-4a96-a80c-a6f476d85cd6.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:25782EF0-8786-446E-ADBA-21F489844237 TCGA-3L-A3YX-01A-PR Redacted LAB NO : C.P# CLINICAL INFORMATION/COMMENTS: FEMALE -YEARS PR PATIENT CODE 1 CONSULTANT: DaTE: PRINTED ON Histogathology Biopsy Small Clinical Note: Carcinoma breast left side.. Microscopic Features: Section examined reveal breast tissue an infiltrative neoplastic lesion composed of cells showing moderate pleomorphism with nuclear hyperchromasia and eosinophilic cytoplasm. Few mitotic figures are seen. Almost 1o0% of the tumor is viable. No areas of necrosis are. seen. Conclusion: Carcinoma left breast :--. Infiltrating Lobular Carcinoma grade I!. 100% of tumor is viable. No areas of necrosis are seen.. 1cs-u-3 Additional Report Cariciena mnfitrutry,bibular nc.s Necrosis : 0% 8520/3 Percent of tumor nuclei . 90% Other nuclei : 10%. Sih: husst nss e'su.9
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diff --git a/output/text/6990828c-d4f1-45a1-8ed5-c9e120c84ac9.txt b/output/text/6990828c-d4f1-45a1-8ed5-c9e120c84ac9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d4abca3f052c9298226ca6d00ef7f7ff2b05b096
--- /dev/null
+++ b/output/text/6990828c-d4f1-45a1-8ed5-c9e120c84ac9.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:E59F60B8-34CD-4E5D-A960-82392A66C136 TCGA-B2-A4SR-01A-PR Redacted Final Surgical Pathology Report. Procedure: Diagnosis Kidney, right, nephrectomy: Renal cell carcinoma, conventional (clear cell) type, size 7.5 cm in greatest dimension (superior pole), with vascular invasion. Microscopic Description: Histologic type: Renal cell carcinoma, conventional (clear cell) type Histologic grade (Fuhrman Nuclear Grade): 4 tumor is grade 2, there are several areas of grade 4 nuclei present). (Although much of the Primary tumor (pT): Tumor is 7.5 cm in greatest dimension (pT2a) Margins of resection: Negative Regional lymph nodes (pN): None submitted Vascular invasion: Present Non-neoplastic kidney: Unremarkable. 1co-0-3 Additional findings: Tumor necrosis. CncinonA Chw cll 831o/3 Specimen Right kidney Sit : Kidny , nos C64-9 Clinical Information Renal mass Gross Description Received fresh for tissue procurement labeled "right kidney" is a 717 g, 13.5 x 8.0 x 7.5 cm right kidney with attached, probe-patent 5.5 cm ureter and a moderate amount of perinephric fat. delicate tan-pink.  The renal capsule is  The specimen is bivalved to reveal a 7.5 x 6.5 x 5.0 cm focally cystic pale tan to yellow orange tumor mass superiorly. A portion of tumor and a portion of normal parenchyma are submitted for tissue procurement as requested.  The tumor is present within 0.3 cm of the inked surface of the specimen.  The renal pelvis is smooth glistening tan white.  The remaining parenchyma is homogenous pale tan red-brown with a well-defined corticomedullary junction and a maximal cortical thickness of 1.3 cm..  No additional mass lesion or abnormality is identified. Summary: 1 - - vascular and ureteral margins, 2 and 3 - tumor to inked surface of specimen, 4 through 7 - tumor 8 - tumor to normal, 9 - renal pelvis, 10 and 11 - random normal.
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diff --git a/output/text/69a10c2c-e7f2-4eb7-8a5c-f5f175a152c0.txt b/output/text/69a10c2c-e7f2-4eb7-8a5c-f5f175a152c0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..66208c64d1b8f0a176384997b956aa1cd8b95dd2
--- /dev/null
+++ b/output/text/69a10c2c-e7f2-4eb7-8a5c-f5f175a152c0.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Sample Number Sample Type TUMOUR Diagnosis  Transitional cell carcinoma. Year of Sample Collection Age at Sample Collection (yrs)  Days to Procedure Date  Days to Diagnosis Type of Procedure Resection - sadical cystoproshtectomy  Site of Tissue/Primary (Histology).  Bladder Tumour Size (cm) 8  Histology Transitional cell carcinoma  Grade/Differentiation III  Pathological T T4  Pathological N  N1  Clinical M MO Histology Comments bladder - tumour - 90% tumour - no necrosis Sample Number Sample Type  BUFFY Year of Sample Collection Age at Sample Collection (yrs)  Days to Procedure Date  Days to Diagnosis  UUID:90EBB6AD-C8DC-44FE-AE88-674F150413278 TCGA-HQ-A5ND-01A-PR Redacted IcD-o-3 8126/3 CsCE Carcmma,urotheliI NDS 812673 Site: Bladder Nos Cb7.9 JOQ1u|13 W H7|3 nary Tumor Site Discrepancy Dual/Synchronous JALIFIED
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diff --git a/output/text/69de5f06-05b8-4a1f-95c5-c16d4bea33cc.txt b/output/text/69de5f06-05b8-4a1f-95c5-c16d4bea33cc.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3732eabb1d0b4c1842bedac7e0b3e249633e321f
--- /dev/null
+++ b/output/text/69de5f06-05b8-4a1f-95c5-c16d4bea33cc.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:164EE426-8661-404C-9E0F-4216A76253C8 TCGA-ZF-A9R9-01A-PR Redacted IcD 0:3 'arenono, wotheIeoI N6S 8lQs/3 SPECIMEN Wreenond, branselina0 cIQ NcS 8120/3 1 - Right iliac lymph node. 2 - Left ureteric resection margin. Sib, RLudsler nsoS Cb7.9 3 - Bladder & prostate. CLINICAL DETAILS J572/)4 Invasive bladder cancer. Left ureter ? is there evidence of tumour in distal part (clinically it appears so) and does this extend to proximal part. MACROSCOPY 1 - Enlarged node measuring 27 x 20 x 12 mm. 2 - An orientated tubular structure 20 mm in length and up to 6 mm in dia. with surrounding fatty tissue. 3 - Specimen consists of bladder (measuring 65 x 40 x 40 mm), prostate (measuring 55 mm medio-lateral x 35 mm supero-inferiorly x 35 mm anterior- posterior) and perivesical fat. The bladder contains an ulcerated lesion measuring 25 x 20 mm involving the posterior and left lateral walls. On section the tumour appears to extend through the wall to reach the perivesical fat and reach the circumferential surgical resection margin posteriorly. No lymph nodes are identified in the perivesical fat.. 1 - Right iliac lymph node;. FROZEN SECTION REPORT 1 - Frozen section report; metastatic carcinoma. Verbal report given to anaesthetics at on the - Dr and Dr PARAFFIN SECTION REPORT Paraffin sections confirm frozen section report of metastatic carcinoma. There is extension into extracapsular tissue.. 2 - Left ureteric resection margin; FROZEN SECTION REPORT 2 - Frozen section report; both proximal and distal ureteric resection margins are normal with no carcinoma in situ. Report to. surgeon at on - Dr PARAFFIN SECTION REPORT Paraffin sections confirm the frozen section diagnosis of morphologically normal ureteric tissue. 3 - Bladder and prostate; Sections from the macroscopically identified lesion confirm a poorly differentiated transitional cell carcinoma arising from surface epithelium and extending as tumour aggregates through the bladder wall to reach the extravesical tissue. There is tumour within 1 mm of the circumferential. surgical resection margin. There is extensive necrosis within the tumour and perineural and lymphovascular invasion. There is no lymphocytic infiltrate at the tumour host interface. Tumour is seen extending into the muscle wall of the ductus deferens. Background urothelium is morphologically normal with no evidence of dysplasia or carcinoma-in-situ. Sections taken from the right ureteric resection margin show small tumour foci within the soft tissue and may represent lymphovascular invasion.. The urethral resection margin of this specimen is morphologically normal with no evidence of dysplasia or carcinoma-in-situ.. The sections from the right lobe of the prostate show foci of high grade PIN.
+
+--- Page 2 ---
+Sections from the left lobe are morphologically normal. There is no evidence of microacinar adenocarcinoma. Please note the urethral resection margin and left external iliac nodes have been processed as SUMMARY Cystoprostatectomy and lymph node dissection; the appearances are those of a poorly differentiated (G3) transitional cell carcinoma of the bladder invading perivesical soft tissue. There is tumour within 1 mm of the circumferential surgical resection margin. No metastases are noted. G3 TCC pT3b pN2 pMx. Pathologists - DR CONSULTANT Joliy
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diff --git a/output/text/6a00db93-5d3a-47b5-b748-e603276002dd.txt b/output/text/6a00db93-5d3a-47b5-b748-e603276002dd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8ec21632689855327ebe130f89af39bf458f99bb
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+FOR ORFICIAL USE ONLY - PERSONAL DATA - PRIVACY AC SURGICAL PATHOLOGY REPORT Patient: Specimen #: FMP/SSN: DOb/Age/Sex: .Age: )F Race: WHITE Taken: Location: Received: Physician(s) :  Reported: 1es-0-3 SPECIMEN: A: RIGHT AXILLIARY SENTINAL L.N. S4u: breast, Nos c50.9 B: RIGHT BREAST MASTECTOMY C: RIGHT BREAST TISSUE D: LEFT BREAST MASTECTOMY 1/2u. h FINAL DIAGNOSIS: A. RIGHT AXILLIARY SENTINEL LYMPH NODE, BIOPSY: -ONE LYMPH NODE WITH RARE INDIVIDUAL CYTOKERATIN-POSITIVE CELLS BY IMMUNOHISTOCHEMISTRY, (LESS THAN O.2 MM IN DIAMETER). B. RIGHT BREAST, MASTECTOMY: INFILTRATING LOBULAR CARCINOMA, MODERATELY DIFFERENTIATED (BLOOM- RICHARDSON SCORE 6). -MAXIMUM TUMOR SIZE 2 CM (GROSS MEASUREMENT) -EXTENSIVE LOBULAR CARCINOMA IN SITU (LN3). -ANTERIOR MARGIN POSITIVE FOR INVASIVE CARCINOMA. -ESTROGEN RECEPTOR POSITIVE; PROGESTERONE RECEPTOR NEGATIVE (SEE S04- -HER 2 NEU NOT AMPLIFIED (SEE C. RIGHT BREAST TISSUE, EXCISION: -NEGATIVE FOR TUMOR. D. LEFT BREAST, MASTECTOMY: FOCAL LOBULAR CARCINOMA IN SITU (LN3). USUAL DUCTAL EPITHELIAL HYPERPLASIA. COLUMNAR CELL CHANGE. commENT: The AJcc stage for the right breast carcinoma is TlcNO(i+) (sn)MX. ER/pR and Her2 neu studies were performed on the previous biopsy, and are not repeated. ** Report Electronically Signed Out ** UUID:F76120C1-B2B2-46EE-AAE1-57B05D258ED1 TCGA-A2-A0EP-01A-PR Redacted Page 1 Continued on Next Page : PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 2 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA RIVACY FCT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: CLINICAL DIAGNOSIS AND HISTORY: -year-old with diagnosis of breast cancer, 1.0 cm spiculated mass right breast. GROSS DESCRIpTION: A. Received fresh, labeled with the patient's name,. designated "RIGHT AXILLARY SENTINEL LYMPH NODE" cOnsists of a 2.0 x 1.6 x 1.0 cm piece of fatty tissue containing a 1.0 cm lymph node. The node is bisected and a 1.0 mm thick section of one of the halves is submitted for the CBcp protocol.. Cassette key:. Al: Bisected lymph node. A2: Remainder of the fatty tissue. B. Received fresh, labeled with the patient's name,. designated "RIGHT BREAST MASTECTOMy" consists of a 950.0 gram simple mastectomy specimen, measuring 22.5 cm medial to lateral, 21.0 cm superior to inferior, and 3.8 cm anterior to posterior. The overlying ellipse of. nipple bearing skin measures 15.0 x 7.5 cm and is notable for a well-healed, curvilinear scar 4.3 cm in length, near the superior lateral edge. The specimen is oriented with sutures. The anterior margin is inked. blue, the posterior margin is inked black. Sectioning reveals a 2.0 cm area of indurated area in the lower inner quadrant at the 5:oo position, abutting the anterior medial margin. The remaining tissue is predominantly fatty and unremarkable. Multiple tissue sections taken for the protocol; matching paraffin sections are as follows: B1: Skin, lateral tip. B2-B4: Tumor. B5: Fibrofatty tissue, 2.0 cm from tumor, lower inner quadrant. B6: Fibrofatty tissue, 14.0 cm from tumor, lower outer quadrant B7: Fibrous tissue, 15.0 cm from tumor, upper outer quadrant. B8: Fibrofatty tissue, 9.0 cm from the tumor, upper inner quadrant. B9-B10: Nipple. 10C16 C. Received in formalin, labeled with the patient's name, designated "RIGHT BREAST INFERIOR TISSUE" cOnSists of a 6.5 x 6.0 x 3.5 cm fragment of fatty tissue. The surface is inked in black. Sectioning reveals predominantly fatty tissue with a minimal fibrous component. Representative sections from throughout the lesion are placed in cassettes C1 through C5.. D. Received fresh, labeled with the patient's name, designated "LEFT BREAST MASTECTOMy" consists of a 1540.0 gram simple mastectomy specimen measuring 24.5 cm medial to lateral, 19.0 cm superior Page 2 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 3 ---
+FOR OFFICIAL USK ONLY SONAL DATA - PRIVACY ACT OF 1974 ^GY 1 SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION (continued) : to inferior, and 5.0 cm anterior to posterior. The overlying ellipse of nipple bearing skin measures 21.0 x 11.5 cm. The specimen is oriented with sutures and inked as follows: Blue-anterior, black=posterior. Sectioning reveals predominantly fat and admixed patches of white, fibrous tissue. No discrete masses are identified. One section of skin and one section of fibrofatty tissue from each quadrant is submitted for the Matching paraffin sections are as follows: protocol. D1: Skin. D2: Upper outer quadrant. D3: Upper inner quadrant. D4: Lower inner quadrant. D5: Lower outer quadrant. D6: Nipple. D7: Upper outer quadrant. D8: Upper inner quadrant. D9: Lower inner quadrant. D10: Lower outer quadrant. Page 3 End of Report FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
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diff --git a/output/text/6a456bfa-a4ff-4bd6-991c-a609eb7d321e.txt b/output/text/6a456bfa-a4ff-4bd6-991c-a609eb7d321e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..bd81b097c92859b55196edec4136031ff834c006
--- /dev/null
+++ b/output/text/6a456bfa-a4ff-4bd6-991c-a609eb7d321e.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UUID:21B4A68D-F76C-4988-81D7-423E957852E10 TCGA-CC-A5UC-01A-PR Redacted zCD O3 (For Collection of Cancerous Tissue) 8s/3 bepaticihubay Carcurere Rsliel Lipe. 8 817/3 Sita. Luver, depatie NOS C 22.O Informed Consent F yk/3 I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the. RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator Signature Date Clinical Information GENERAL INFORMATION Date of Rirth (mm/dr/w) Height  Marital Status Race Temperature I6S  Single PMarried Viamamede Gender Weight  Divorced  Widow  Blood Pressure Heart Rate Male  Female 5Fcc) L3r HISTORY OF PRESENT ILLNESS Chief Complaints: Ahcltmu ncll pcuin j Jevuw j Symptoms: WackniS j weighf loss Clinical Findings: Performance Scale (Karnofsky Score):  100 Asymptomatic  80-90 Symptomatic but Fully Ambulatory 60-70 Symptomatic, in bed less than 50% of day  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden     20-30 Bed Ridden CURRENT MEDICATIONS Drug Dose Route Frequency Date (mm/dd/yyyy) To To To To / To /
+
+--- Page 2 ---
+PAST MEDICAL HISTORY Diagnosis/Disease/Disorder/Injury  Diagnosis Date Treatment Status OB/GYN HISTORY Menopausal Status Date of First Menses. # of Pregnancies  Pre-menopausal  Peri-Menopausal Date of Last Menses # of Live Births  Post-menopausal Birth Control:  Condom  Oral Contraceptive IUD  Hormone Replacement  Other: Therapy: SOCIAL HISTORY Occupation: Environmental Hazards: Smoking History Current Status TYPE Packs/day Duration When Quit  yES NO (yrs) (yr Alcohol Consumption Current Status TYPE Drinks/day Duration When Quit 2Anio ca 3 ( (yrs) (3xmitbs)(r)  YES NO Drug Use 3 Current Status TYPE Frequency Duration When Quit  YES QNO (yrs) (yr) FAMILY MEDICAL HISTORY  Diagnosis Age of Diagnosis Relative LAB DATA Date Test Result Date Test Result CEA Negative  Positive: HIV Negative  Positive: Hep B Negative CA 15-3 Negative  Positive: Positive: Hep C CA 19-9 Negative  Positive: Negative Positive:   Negative PSA   Negative  Positive: AFP  Positive: Other: Other:  Negative Positive: Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+DIAGNOSTIC STUDIES Study Results Date Ultrasound  Yicss X-Ray CT Endoscopy MRI Biopsy CLINICAL DIAGNOSIS Preoperative Clinical Diagnosis Liyer. Caueer Location of Suspected Involved Lymph Nodes. Location of Suspected Distant Metastasis Cllnical Staging Date of Diagnosis T3 No MO Stage: IA Treatment Information. SURGICAL TREATMENT Procedure Date of Procedure Pesectir the Diot  Primary Tumor Organ Detailed Location Size Linee LeuMrer Mer 8xZ xcm Extension of Tumor Lymph Nodes Description Location of Lymph Nodes. # of Lymph Nodes Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Organ Detailed Location Size Surgical Staging T3 NOMe Stage:  A NEOADJUVENT THERAPY (Chemo, Radiation, Immuno, Hormonal, or Molecular) Drug/Treatment Dose Route Frequency Date (mm/dd/yyyy) To 1 To 1 To 1 To / To 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by: -- Date: . Time... Date: .Time._. Preserved by: - SPECIMEN TYPE (# of samples provided) Frozen Paraffin Block Blood/Serum/Plasma Slide Diseased Normal Diseased Normal Diseased Normal Diseased Normal 2 2 4 Time to LN2 Time to Formalin Time to LN2 min min min PATHOLOGICAL DESCRIPTION Primary Tumor Organ Size Extension of Tumor Distance to NAT I leen Deetu? 8 xZxScm 6 cm Lymph Nodes Location # Examined # Metastasized Distant Metastasis Organ Detailed Location Size Pathological Staging pT 3 NO M c) Stage: -TU Notes: 4
+
+--- Page 5 ---
+Consolidated Pathology Diagnosis er Histological Pattern Cell Distribution + Structural Pattern Diffuse Streaming  Mosaic Y  Storiform Necrosis VFibrosis Lymphocytic Infiltration  Palisading  Vascular Invasion  Cystic Degeneration Clusterized  Bleeding Alveolar Formation  Myxoid Change Indian File  Psammoma/Calcification am eoelhular Dinrerentton Squamous + Adenomatous + Sarcomatous + Lymphomatous  Squamoid Cell Glandular cell Round Cell Large Cell Spindle Cell Cell Stratification Fibroblast Small Cell Keratin Secretlon IX Osteoblast  RS Cell/RS Like  Desmosome Intracyt. Vacuole X Lipoblast Inflam. Cell Pearl  Gland formation Myoblast  Plasma Cell Cellular Differentiation: o Well  Moderate YPoor He NuclearAppaarancero Nuclear Atypia: 0 1 II III Aniso Nucleosis Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell  Mitotic Activity Nuclear Grade: X d7 Dr7Z D3G(Z Dy 7S/ Final Pathology Report SoUc HDe Comments: Date Director, Research Pathology riterla 27/13 mary Tumor Site Discrep HIPAA Dis er Initials
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diff --git a/output/text/6a4d5cf0-c49d-4f19-927c-d7499326239d.txt b/output/text/6a4d5cf0-c49d-4f19-927c-d7499326239d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..03de9d9dc258876f97a42eba78556efc7797db4c
--- /dev/null
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+
+--- Page 1 ---
+UUID:A23D86FF-CCA9-42B2-B6AE-9E365AAC03C8 TCGA-E9-A295-01A-PR Redacted Procurement Date: . Laterality:Right lower outer quadrant 1cs-0-3 Path Report:BREAST TISSUE CHECKLISTE Caciioma 1obuluv N0s c52o13 Specimen type: Radical mastectomy Site: brast, Nos Cs~0.9 5/231 Specimen size: Not specified Tumor site: Breast Tumor size: 4.2 x 4 x 4 cm Grossly evident lesion: Yes H311 Histologic type: Lobular carcinomap Histologic grade: Moderately differentiated Tumor extent: Skin Lymph nodes: 0/7 positive for metastasis (Regional 0/7) Extracapsular invasion of the lymph nodes: Not specified Margins: Not specified Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None
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diff --git a/output/text/6a4f55bd-55a6-478d-9a1b-aea95d11e650.txt b/output/text/6a4f55bd-55a6-478d-9a1b-aea95d11e650.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a200ae7eb6b5f2b95e58112fc979116a4e1618f1
--- /dev/null
+++ b/output/text/6a4f55bd-55a6-478d-9a1b-aea95d11e650.txt
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+
+--- Page 1 ---
+SURGICAL PATHOLOGY REPORT SPECIMEN CLINICAL NOTES PRE-OP DIAGNOSIS: Right colon cancer GROSS DESCRIPTION Received fresh labeled "right colon" is a previously unopened 30 cm.  segment of proximal right colon with attached 8 cm. of distal ileum surfaced by smooth tan pink serosa. unremarkable omentum. No appendix is identified.  The proximal and distal margins measure 4.0 and 8.0 cm. in circumference respectively. On opening,. there a moderately well circumscribed, 4.5 x 3.8 cm. rubbery tan white-pink tumor mass located 9 cm. distal to the ileocecal valve. A portion of tumor and a portion of normal. mucosa are submitted for tissue procurement as requested. On sectioning, the tumor has a maximal thickness of 1.8 cm., grossly extending into the muscularis to within 0.6 cm. of the inked free radial serosal surface. A few soft tan ink polypoid lesions measuring up to 0.6 cm. in greatest dimension are present throughout the remainder of the colon. The ileal and remaining colonic mucosa is unremarkable, glistening tan pink with regular folds and the. walls average 0.5 cm. in thickness. Multiple soft to slightly rubbery pale tan to tan-red tissues in keeping with lymph nodes measuring up to 1.2 cm. in greatest dimension are recovered from the attached mesocolon and mesentery..  Representative sections are. submitted in 15 blocks as labeled.  RS-15. BLOCK SUMMARY:  - Proximal and distal margins; 2, 3 - tumor full thickness to inked free radial serosal surface; 4 - central tumor; 5.  tumor to normal mucosa; 6, 7 - colonic polyps; 8 - Icv; 9 - random colon; 10-12 - six whole lymph nod. per cassette; 13-15 - one bisected lymph node per cassette. MICROSCOPIC DESCRIPTION Histologic type: Adenocarcinoma Histologic grade: Poorly differentiated Primary tumor (pT): Tumor invades through the full thickness of the. wall into the adjacent adipose tissue, pT3 Proximal margin: Negative for tumor Distal margin:  Negative for tumor Circumferential (radial) margin:  Tumor is not identified at the. outer serosal surface of the specimen. Distance of tumor from closest margin: 21 cm from distal margin of. excision Vascular invasion: Present in pericolonic tissue. Regional lymph nodes (pN): Two of twenty-three lymph nodes positive for metastatic carcinoma (2/23), pN1b Non-lymph node pericolonic tumor:  Perineural invasion by tumor is. identified
+
+--- Page 2 ---
+Distant metastasis (pM) : pMX Other findings:  Separate adenomatous polyps are identified within the colon. 5x1 DIAGNOSIS Colon, right, excision - Invasive poorly differentiated adenocarcinoma a (see tumor characteristics in the colon resection template in the microscopic description).  End Of Report
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diff --git a/output/text/6a597222-44f9-4409-90cd-82e65413b33d.txt b/output/text/6a597222-44f9-4409-90cd-82e65413b33d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4dacc944c0f09243a56356a388eb7199679c6f03
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+JUID:51863920-F05E-475 1130 TCGA-CV-A45Z-01A-PR Redacted DOB Sex: M  Physician. Received: Pathologist: Accession: Case type: Surgical History ** Case imported from legacy computer system. The format of this report does not match the original case. * ** For cases prior to section "SPECiMEN" may have been added. ** DIAGNOSIS 1cd-0-3 (A)  RIGHT FALSE CORD: 8070/3 INVASIVE SQUAMOUS CARCINOMA. StHt: 1arymx, Nos c32.9 (B) NOSE RIGHT PAROTID BULB: Lymph node, no tumor. RIGHT THYROID LOBECTOMY: Multinodular goiter.. ARYNGECTOMY: SQUAMOUS CARCINOMA, GRADE 3 WITH LYMPHATIC INVASION INVOLVING RIGHT AND LEFT SUPRAGLOTTIC REGIONS. MARGINS OF RESECTION FREE, THICKNESS OF THE TUMOR, 1.2 CM. SQUAMOUS CARCINOMA IN SITU IN RIGHT VENTRICLE. Large tracheal margin of resection free of tumor. Seven right cervical 1ymph nodes, no tumor. Two cervical lymph nodes, no tumor. Entire report and diagnosis completed by: Reoort released by:. GROSS DESCRIPTION (A) Rrght FALsE coRo - Three fragments of tan-pink tissue admixed with blood clot (overall 0.5 x 0.4 x 0.2 cm). Entirely submitted for frozen section in A. *-S/DX: SQUAMOUS CELL CARCINOMA, INVASIVE. (B) NODE, RIGHT PAROTID~BULB -*A 1ymph node, 1.5 x 0.6~x 0.7 cm. Bisected in toto in 8. (C)* RIGHT THYROID LOBEcTOMy - A right lobe of the thyroid (5.0 x 3.0 x 1.7 cm), with several nodules, .ranging from 0.2 to 1.1 cm. A more preserved portion of thyroid tissue is at the superior aspect, it is red-brown and meaty; the nodules range from red to 1ight brown color. 'The specimen sampled for frozen section in C1 and c2; representative sections are submitted in c3-c6. INk cope: Yellow - isthmus margin; blue - thyroid surface.. (D)  LAryngecromy - A laryngectomy and attached soft tissue and iympn node dissection with overall measurements of 8.0 x 6.0 x 5.0 cm.. *A 1ight tan indurated and ulcerated lesion located in the right supraglottic area and extending to the midline approximately 0.5 cm into the 1eft supraglottic area is 2.0 x 1.5 x 1.0 cm mass. The mucosal and external.  surfaces specimen are uninvolved grossly by tumor. The specimen is submitted sequentially from right to left Secrron cooe: D1-D17, lymph nodes, right; D18-D19, lymph nodes, left. Page 1 of 2 History Case Pathology Report. History Case Pathology. File under: Pathology
+
+--- Page 2 ---
+DOB: Sex: M Physician: Received Pathologist: Accession: Case type: Surgical History *FS/DX: MUCOSA, NO TUMOR PRESENT. ADDITIONAL STUDIES PHOTO: (A) LARYNX SNOMED CODES M-80703 T-24455 R0412 Page 2 of 2  History Case Pathology Report History Case Pathology File under: Pathology
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diff --git a/output/text/6a5bd290-a975-4d46-8f84-ce708c412f25.txt b/output/text/6a5bd290-a975-4d46-8f84-ce708c412f25.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a380dbfe0f1cb5d4d0d92ee6dd5174a8980cf3a1
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+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACV ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: FMP/SSN: DOb/Age/Sex: Age: F Race: WHITE Taken: Location: Received: Physician(s) : Reported: 1Cs-0-3 **AMENDED** carcinomo,infiltnatng ductal, Nos 85001j Site. Bnast Nos C50.9 SPECIMEN: 1/35/ lu A: INTERPECTORAL NODE B: LEFT BREAST AND AXILLARY CONTENTS FINAL DIAGNOSIS: A. LYMPH NODE, LEFT INTERPECTORAL, EXCISION: - METASTATIC DUCTAL CARCINOMA WITH EXTRACAPSULAR EXTENSION SIZE OF DEPOSIT: 0.6 CM EXTENT OF EXTRANODAL TUMOR: 4 MM (See comment; ONE LYMPH NODE EXAMINED. B. BREAST AND AXILLARY CONTENTS, LEFT, MASTECTOMY WITH REGIONAL LYMPH NODE DISSECTION: INVASIVE DUCTAL CARCINOMA, WELL DIFFERENTIATED (NOTTINGHAM SCORE 5) TUBULE FORMATION 20% = 2 NUCLEAR PLEOMORPHISM = 2 MITOSES 9 per 10 HPF AT 40X FIELD AREA 0.2376 SQ.MM = 1 INVOLVING THE DERMIS, EPIDERMIS, AND NIPPLE; WITH ULCERATION SIZE = 7.0 CM (GROSS DIMENSION). DEEP (SKELETAL MUSCLE) MARGIN IS INVOLVED BY TUMOR. LYMPH VASCULAR AND PERINEURAL INVASION IS IDENTIFIED. SEVEN OF ELEVEN EXAMINED LYMPH NODES WITH METASTATIC CARCINOMA; EXTRACAPSULAR EXTENSION IS PRESENT, EXTENT OF EXTRANODAL TUMOR: AT LEAST 6 MM (See comment;) MAXIMUM DIMENSION OF LARGEST DEPOSIT:  1.8 CM - AJCC CLASSIFICATON: pT4b(ulceration)N2aMX. COMMENT : The report is amended on to add the extent of extracapsular extension of tumor in response to a request from the tumor board.  The measurement is the distance from the estimated location of the obliterated lymph node capsule to the outer extent of the tumor deposit on the. microscopic slide. UUID:A985FB5C-9E91-40E1-864E-CEA887B3866D TCGA-A2-A0CS-01A-PR Redacted Page 1 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 2 ---
+TOR OFFICIAL US ONLY SURGICAL PATHOLOGY REPORT Patient: Specimen #: FINAL DIAGNOSIS (continued): Report Electronically Signed Out. 1 CLINICAL DIAGNOSIS AND HISTORY: -year-old white female with left breast cancer. PRE-OPERATIVE DIAGNOSIS: Left breast cancer.. POST-OPERATIVE DIAGNOSIS: Operative Findings: Left breast cancer. Post-Operative Diagnosis: Left breast cancer. GROSS DESCRIpTION: A. Received fresh, labeled with the patient's name, designated "INTERPECTORAL NODE" consists of an apparent lymph node, measuring 1.3 x 0.9 x 0.6 cm. The node is bisected revealing firm, yellow and tan tissue. One half of the specimen is submitted for the CBcr. protocol. The remaining half is submitted for permanent section. B. Received fresh, labeled with the patient's name, modified radical mastectomy specimen. The breast measures 17.5 x 14.5 x 3.8 cm, attached axillary contents measure 13.0 x 5.2 x 1.5 cm, and overlying nipple-bearing skin measures 13.0 x 9.5 cm. INK coDE: Blue=superior superficial, green-inferior superficial, and black-deep. The axillary contents are examined and disected from the breast and has multiple palpable lymph nodes, many of which are suspcious for metastasis. A large portion of the skin is covered with gauze dressing, which is removed, revealing areas of retraction and ulceration (largest 2.2 x 1.6. cm) superior to the nipple/areolar complex, overlying a large palpable. tumor. The breast is sectioned from the posterior aspect revealing a 7.0 x 5.1 x 3.5 cm tumor, which anteriorly erodes through the skin and posteriorly involves a 3.0 x 2.5 cm segment of skeletal muscle. The tumor is centrally-located and extends into the upper mid and upper inner portions of 'the breast. It has a firm, tan, gritty cut surface. The remaining Page 2 Continued on Next Page. FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 3 ---
+PRSONAL DATA - PRIVACY ACT OF 1974 R SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION (continued) : breast tissue is predominantly fatty and unremarkable. Multiple sections are submitted for the cBcp protocol with matching paraffin sections as follows: B1: Lymph node, lower portion of axillary tail, 1.8 x 1.7 x 1.3 cm.. B2: Grossly normal lymph node, mid upper portion of tail. B3: Grossly normal skin (medial tip).. B4: Skin with underlying tumor.. B5: Skeletal muscle with tumor.. B6: Tumor, medial aspect.. B7: Tumor, lateral aspect. B8: Grossly normal fibrous tumor, inferior to tumor.. B9: LIQ, 3.5 cm from tumor. B10: LOQ, 4.0 cm from tumor. B1l: uoQ, 3.5 cm from tumor.. B12: UIQ, 2.0 cm from tumor. B13: Nipple. B14-B17: One lymph node, bisected, in each cassette. B18: Five potential lymph node candidates. 18crss. Page 3 End of Report FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
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diff --git a/output/text/6a6d65d8-08ed-441a-8e6c-13d1bb7ad4ac.txt b/output/text/6a6d65d8-08ed-441a-8e6c-13d1bb7ad4ac.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fcffaa49c7106762d02f1a896c333f586babd1f4
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+
+--- Page 1 ---
+JcD-J-3 Carcunoms mnfi1trahing 1obulu,N0s85x0/3 PeH Srts: Brcast uF4 C50.J 119/n h cqcF Sit: Cusst,nfs c50.9 Diagnosis: Moderately differentiated invasive lobular carcinoma (tumor diameter 2.2 cm) with several further satellite foci measuring up to 0.1 cm and also focal in situ spread.. In conjunction with the preliminary finding, this gives rise to the following concluding tumor classification: lobular carcinoma, G II, pT2N0(0/3;sn)L0V0R0.. UUID:E0804FB6-9500-4786-B6D9-303165EF9090 Redacted 11111
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diff --git a/output/text/6a8aaade-1733-4710-bb24-21645b0f1873.txt b/output/text/6a8aaade-1733-4710-bb24-21645b0f1873.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3e4ae75e4ace2885c356bdf7edf2c96ae3085131
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Clinical Diagnosis & History: 1/o female with 5.5 cm right breast cancer. Specimens Submitted: 1: sp: Right breast and axillary conteats levels 1 and 2 (sx) DIAGNOSIS: 1. BREAST, RIGHT; MODIFIED RADICAL MASTECTOMY: sted - MULTICENTRIC IAVASIVE LOBULAR CARCINOMA, CLASSICAL TYPE, WITH A SOLID PATTERN, MEASURING 5.5 CM IN LARGEST DIMENSION GROSSLY.S - LOBULAR CARCINOMA IN SITU (LCIS) IS ALSO IDENTIFIED, ea - THE INVASIVE CARCINOMA IS LOCATED IN THE LOWER OUTER QUADRANT, LEFT INNER QUADRANT, CENTRAL AREA.S - THE NIPPLE IS INVOLVED BY INVASIVE CARCINOMA. - NO CALCIFICATIONS ARE IDENTIFIED IN EITHER THE INVASIVE OR IN SITUS COMPONENT. -NO VASCULAR INVASION IS NOTED.  PERINEURAL INVASION IS PRESENT. INVASIVE CARCINOMA EXTENDS TO THE CAUTRRIZED ANTERIOR FLAP MARGIN. THE SKIN IS INVOLVED BY INVASIVE CARCINOMA BY DIRECT EXTENSION. THE NON-NEOPLASTIC BREAST TISSUE SHOWS USUAL DUCTAL HYPERPLASIA AND MICROCALCIPICATIONS ASSOCIATED WITH BENIGN DUCTS. THE LYMPH NODE STATUS IS AS FOLLOWS (EXPRESSED AS THE NUMBER OF POSITIVE I: 0/7; LEVEL II: 0/6. IMMUNOSHISTOCHEMICAL STAIN DEMONSTRATE SINGLES ISOLATED TUMOR CELLS WITHIN THE NODAL PARENCHYMA SEEN ONLY ON IMMUNOHISTOCHEMICAL STAINED SLIDES (AEI/AE3) AND MEASURING LESS THAN O.2 MM. EJor_98 - ER: BST NUCLEAR STAINING WITH MODERATE INTENSITY - PR: 40% NUCLEAR STAINING WITH MODERATE INTENSITY - HER2/NEU(HERCEPTEST) : NEGATIVE (STAINING INTENSITY OF 0) TUMOR STAGE: T3, PNO(I+), MX "fet/01 I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED my *+ Continued on next page **.
+
+--- Page 2 ---
+THIS REPORT. Page 2 of 3 2 Report Electronically Signed Cut * Special Studies: Result Special Stain er-c Comment pR-C HER2-C IMM RECUT NEG CONT NEG-HER2 AE1:AE3 AE1:AE3 IMM RECUT NEG CONT IMM RECUT NEG CONT 1). The specimen is received fresh labeled, " Right modified radical. mastectomy with levels one axillary contents with ievel one and two", and consists of a breast measuring a 33.2 x 20.3 x 4.5 cm, with overlying skin ellipse measuring 1i.2 x 2.6 cm, and without scar. The nipple measures 1.6 cm in diameter. The posterior surface of the breast is inked black and anterior inked yellow. The specimen is serially sectioned to reveal an ill-defined mass above the nipple area (12:00), measuring 2.3 x 1.5 x 1.3. cm. The mass is closed to the skin and 2 cm away from deep margin. There is fibrous tissue adjacent to the mass occupying the lower outer quadrant and lower inner quadrant. Multiple lyuph nodes are noted in the axillary area. the largest one measures 1.2 cm in dimension. Representative sections are submitted. Sunmary of sections:. NIP - nipple D - deep margin. T-mass upper inner quadrant. LIQ lower inner quadrant UOQ upper outer quadrant LOQ - j lower outer quadrant L1- lymph nodes (level 1) L2- lymph nodes (level 2). ** Continued on next page
+
+--- Page 3 ---
+Summary of Sections: Part 1:  SP: Right breast and axillary contents levels i and 2 Block Sect. Site. 1 pCs 1 base 93 2 #4 1i4 1 N13 In 104 1 nip 2N t uiq uoq 20 End of Report.
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diff --git a/output/text/6aa0e372-a86c-4ae0-8222-906842e35981.txt b/output/text/6aa0e372-a86c-4ae0-8222-906842e35981.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b0648188a0daa0e50773229e4327cf15af056fbf
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+
+--- Page 1 ---
+TSS ID: TSS ID OC iD Date of Procurement - Gross Description: Ics -0-3 Lump with the tumor of 1.2 x 1.3 cm in size. Cartnonp m`fHtrstng duct,N0s 85oo|3 Fatty tissue lymph nodes demonstrate lipomatosis. Site: bust, N15 c50.9 y/9/n p Microscopic Description: Infiltrating duct carcinoma; G3. Ten dissected lymph nodes demonstrate focal fibrosis, reactive hyperplasia of the follicles. Diagnosis Details: Tumor Features: Unknown, Tumor Extent: T1 tumor size 2 cm or less, Venous Invasion: Absent, Margins: Absent, Treatment Effect: Comments: Formatted Path Report: BREAST TISSUE CHECKLIST Specimen type: Lumpectomy Specimen size: Not specified Tumor site: Upper outer quadrant Tumor size: 1.3 x 0 x 1.2 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinoma Histologic grade: Poorly differentiated Tumor extent: Not specified  Lymph nodes: 0/10 positive for metastasis (Axillary 0/10) UUID:AA095896-8217-4BEE-97EC-BC79F5C395BA Redacted TCGA-E9-A1R4-01A-PR Extracapsular invasion of the lymph nodes: Not specified Margins: Uninvolved Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified 4/8/
+
+--- Page 2 ---
+TSS ID: Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None  Laterality: Left, upper outer quadrante
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diff --git a/output/text/6ab58898-b306-4986-97ab-4f452fb57151.txt b/output/text/6ab58898-b306-4986-97ab-4f452fb57151.txt
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index 0000000000000000000000000000000000000000..5916ecf25c871e75d92e8da87c8fc056363720ac
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+
+--- Page 1 ---
+UUID:0FEAEEBA-A72C-4207-AC21-6AF58SED1AFC TCGA-A2-A3Y0-01A-PR Redacted Specimen: Received: Status: Spea Type: : SURGICAL P Subm Dr: PREOPERATIVE DIAGNOSIS 1<D03 c05<in0mg,infi haHng ducf,Ns 8 SxIf3 LEFT BREAST CANCER INVASIVE OPERATION PERFORME Jm+h: brrgsf,upper 0wkr 9uadran+ Ce,4 DATE: 5-z3|Z DOCTOR(S) : PROCEDURE: MASTECTOMY MODIFIEDARA RD I'ISSUE REMOVED A. LT BREAST AND AXILLARY TISSUES B. ADDITIONAL LYMPH NODES LT AXILLA GROSS DESCRIPTION PART A RECEIVED FRESH LABELEDS LEFT BREAST AND AXILLARY CONTENTS SUTURE AT 12 O'CLOCK, AND CONSISTSS A MODIFIED RADICAL MASTECTOMY SPECIMEN WITH OVERALL DIMENSIONS OF 31 X 20.5 X 5.8 CM.  THE NIPPLE IS UNREMARKABLE AND SITS WITHIN A SKIN ELLIPSE MEASURING 21 X 12.3 CM. THERE IS A 3.5 CM IN LENGTH WELL-HEALED PERIAREOLAR SCAR EXTENDING FROM 12 TO 2 O'CLOCK. THERE IS A PALPABLE MASS IN THE UPPER OUTER QUADRANT. THE SUPERFICIAL ASPECT IS MARKED WITH BLUE INK, THE DEEP ASPECT WITH BLACK INK.  THE AXILLARY TAIL IS REMOVED AND EXAMINED FORS LYMPH NODES, OF WHICH MULTIPLE ARE IDENTIFIED.S SECTIONS ARE SUBMITTED AS FOLLOWS: A4-~THREE NODES, EACH BISECTED; A5--THREE NODES, EACH BISECTED; A6--SECTION OF ONE NODE; A7--SECTION OF ONE NODE; A8--SECTION OF ONE NODE; A9--SECTION OF ONE NODE; A1O--SECTION OF ONE NODE. NOTE THAT A6 THROUGH A1O ARE MIRROR IMAGES OF PROTOCOL SECTIONS. A11--TWO NODES, EACH BISECTED.  SECTIONING THE BREAST REVEALS THE UPPER OUTER QUADRANT TO BE A ROUNDED PINK-TAN SOFT MASS WHICH IS CENTRALLY CYSTIC.  IT MEASURES( 4 X 3.7 X 2.8 CM. GROSSLY, THIS ABUTS THE DEEP MARGIN.  IMMEDIATELY SUPERFICIAL TO THIS MASS IS A SECOND NODULE WITH A COIL CLIP MEASURING 1.5 X I.2 X 1.0 CM. MEDIAL AND CENTRAL TO THE BREAST, THE SPECIMEN HAS A TAN FIBROUS BAND WHICH EXTENDS 9 CM FROM SUPERIOR TO INFERIOR AND THERE IS TAN FIBROUS TISSUE CENTRAL WITHIN THE BREAST.  THIS IS SURROUNDED BY A PERIMETER OF BLAND YELLOW FATTY TISSUE. SECTIONS ARE SUBMITTED AS FOLLOWS: A15 AND 16--MASS IN DEEP MARGIN; A17--SECTION OF THE MASS AND THE ADJACENT MORE SUPERFICIAL NODULE; A18, 19 AND 20--SECTIONS OF MASS CORRESPONDING TO SECTIONS FROM THE SUBMITTED PER PROTOCOL, WITH A20 REPRESENTING THE ADJACENT FIBROUS TISSUE; A21--AN ADDITIONAL SECTION OF THE SUPERFICIAL LESION (MIRROR IMAGE TO PROTOCOL) ; A22--UPPER OUTERS QUADRANT; A23--UPPER INNER QUADRANT; A24--LOWER INNER QUADRANT;: A25--LOWER OUTER QUADRANT (A22 THROUGH A25 ARE MIRROR IMAGE SECTIONS TO PROTOCOL) ; A26--TISSUE FROM SUPERIOR PORTION OF BREAST. THE AXILLARY TAIL IS REEXAMINED FOR LYMPH NODES AFTER FIXATION TIME IN ACETIC FORMALIN. ADDITIONAL NODES ARE THEN SUBMITTED AS FOLLOWS:
+
+--- Page 2 ---
+renty Received: Status: Specimen: Spec Type: SURGICAL P Subm Dr: GROSS DESCRIPTION (Continued) A27--FIVE NODES; A28--TWO NODES, EACH BISECTED. ADDITIONAL LYMPH NODES PART B RECEIVED FRESH LABELED LEFT AXILLA (LEVEL 2), IS YELLOW-PINK FATTY TISSUE MEASURING 2.4 X 1.6 X 0.8 CM. THIS IS BISECTED REVEALING NO DISTINCT NODAL TISSUE AND SURMTTTEN RNTIRELY LABELED B1 AND 2. PATH PROCEDURES PROCEDURES: 88309, A BLK/26, B BLK/2 INAL DIANOSIS PART A LEFT MODIFIED RADICAL MASTECTOMY:S 1 DC POORLY DIFFERENTIATED INFILTRATING DUCT CARCINOMA, NUCLEAR GRADE Hcm III/III WITH A HIGH MITOTIC INDEX, 4.O CM IN MAXIMUM GROSS DIMENSION. THE TUMOR IS LOCATED I MM FROM THE DEEP MARGIN OF THE SPECIMEN. I Intramamnf. 2. METASTATIC CARCINOMA IDENTIFIED IN 1 INTRAMAMMARY LYMPH NODE (MARKED WITH A COIL CLIP CONFIRMING A PREVIOUS BIOPSY SITE).S 3. NO EVIDENCE OF METASTATIC DISEASE IN 37 AXILLARY LYMPH NODES. 4. PERIDUCTAL CHRONIC MASTITIS IN SECTIONS OF BREAST TISSUE AWAY FROM THE PRIMARY TUMOR SITE. SMAII. LYMPH NODE WITH NO EVIDENCE OF METASTATIC DISEASE.S THE JDITION OF THE AJCC STAGING MANUAL DOES SPECIFICALLY NOT ADDRESS STAGII. FOR POSITIVE INTRAMAMMARY NODES IN THE ABSENCE OF AXILLARY METASTATIC DISEASE, HOWEVER THE PATIENT WILL BE STAGED AS HAVING NI DISEASE. 1 (prelim.) Signed (signature on file)
+
+--- Page 3 ---
+Specimen: Received: Status: Spec Type:  CA SUMMARY Subm Dr: Breast Pathology Summary: Macroscopic: Breast procedure: mastectomy, modified radical Lymph node procedure: Sentinel (yes/no): no Axillary (yes/no): yes Specimen size (greatest dimension) (xy,n/a) cm: 31 Neoadjuvant therapy (yes/no): no Laterality: left Tumor site: upper outer quadrant Multifocal (yes/no): no Multicentric (yes/no): no Microscopic: Size of invasive component (xy,n/a) mm: 40 Size of DcIs (xy,n/a) mm: n/a Histologic type: Atypical: n/a In situ: n/a Invasive: infiltrating duct Histologic grade : Tubule formation (0-3,n/a): 3 Nuclear pleomorphism (0-3,n/a) : 3 Mitotic count (0-3,n/a): 3 Nottingham Score: 9 Nottingham Grades based on total score: Grade I  3-5 points Grade II 6-7 points Grade IIr 8-9 points Venous/lymphatic invasion (yes/no): no Closest margin size (xy,n/a) mm: 1 If less than 2 mun then: Single focus of invasive tumor (yes/no): yes Single focus of Dcis (yes/no): no Multifocal invasive tumor (yes/no): no Multifocal Dcis (yes/no): no Nodes: Sentinel- number examined (xy,n/a) : 0 Sentinel- number involved (xy,n/a): n/a Regional- number examined (xy.n/a): 39 Regional- number involved (xy,n/a): 1 Markers: ER (xy$,n/a): 95
+
+--- Page 4 ---
+Req#: Specimen: Received: :atus: Spec TYpe: CA SUMMARY Subm Dr: TANCER SUMMARY (Continued) PR (xy*,n/a): 0 Her-2/neu (0-3+,n/a): 1 Ki-67 (xyt,n/a): 95 Summary TNM: T: pT2 pN:pN1 Summary stage: 2B ) (prelim.) Signed (signature on file)
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diff --git a/output/text/6aeddc22-5022-4dc5-baf1-67ddb2b27350.txt b/output/text/6aeddc22-5022-4dc5-baf1-67ddb2b27350.txt
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index 0000000000000000000000000000000000000000..88fb17e097468844456a8b8ede23bcd0cd69883a
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+Patient Name: Accession #: Med. Rec. #: Date of Procedure: DOB. Dato of Roceipt: Gonder: Date of Report: Ref. Physician: Account# Patient Address Billing Type. Adkditional Copy to. Ret. Source: Clinical Diagnosis & History:. Right renal mass s/p iR biopsy that demonstrated high grade, renal cell carcinoma. Specimens Submitted: 1: MESENTARY, OVERLYING RIGHT RENAL TUMOR: BIOPSY 2: GEROTA'S FASCIA, ANTERIOR; BIOPSY 3: KIDNEY. LOWER POLE AND CAVAL LYMPH NODES, PARTIAL NEPHRECTOMY DIAGNOSIS: MESENTARY, OVERLYING RIGHT RENAL TUMOR; BIOPSY: Benign fibrofatty tissue 2. GEROTA'S FASCIA, ANTERIOR; BIOPSY: -Benign fibrolalty tissue  KIDNEY, LOWER POLE AND CAVAL LYMPH NODES, PARTIAL NEPHRECTOMY Tumor Type: Renal coll carcinoma - Unclassilied type. High grade. See comment Tumor Size. Greatest diameter is 4.2 cm Local Invasion (for renal cortical lypes): Involves renal sinus fat Renal Vein Invasion: Not identified however. lunor involves muscular branches of the renal vein Surgical Margins: Tomor present at renal parenchymal margin (for partial nephrectomy specimens only) Non-Neoplastic Kidney: Chronic nophritis, mild arteriolonephrosclerosis Adrenal Gland: Not identified Lymph Nodes: Number of motastatic nodes:3 Number of nodes examined:8 The largest metastatic deposit measures 1cm and occupies the entire lymph node. Extranodal extension is absent. The majorily of the metastatic tumor is necrolic. Page 1 of 3
+
+--- Page 2 ---
+Staging for renal cell carcinoma/oncocyloma: pT3 Tunor extends into major veins or invades the adrenal gland or perinephric lissues. but not beyond Gerota's fascia Comment: This high grade tumor has features seen in both distal nephron (collecting duet) and "typo 2" papillary rena!. carcinoma. It is inunoreaclive for racemase bul nol CK7, CEA or 34BE12.. IATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (ANDIOR OTHER MATERIAL), AND THAT THAVE REVIEWED ANO APPROVED IHIS REPORT Speclal Studles: Result Special Stain Comment PAS 34BE12 CK7 RACEMASE CEA M IMM RECUT NEG CONT RECUT Gross Description: 1). The specimen is received fresh for frozen section consultation. labeled "mesentery overlying right anterior kidney lumor' and consists of a 1.2 x 0.3 x 0.3 cm fragment ol fally tissue. Entirely submitted for frozen section.. Summary ol sections: FSC -- frozen section control 2). The specimen is received fresh for frozen section consultation, labeled "Anterior Gerota's fascia" and consists of a 0.8 x 0.5 x 0.3 cm portion of fibrofally tissue. Entirely submitiod for frozen soction.. Summary of sections: FSC -- frozen section control 3) Tho specimon is roceived treslt and is rabeled 'right lower pole kidney tunor and perinephric fat. paracaval lymph nodes" It consisls of a 5.8 x 5.5 x 3.2 cm wedge shaped portion of kidney with a suture marking the deep margin. The margin is inked black and the specimen is serially sectioned to reveal a helerogeneous yellow/tan to white mass with areas of necrosis and hemorrhage  that measures 4.2 x 3.5 x 2.4 cm and locally abuls the inked surgical margin and exlonds into the perinephric fat. All identilied lymph nodes are subnitied. Representatively submitted Portions of the tumor are submitted for TPs and photos are taken. Summary of sections T - tumor Mmargin RS - representalive sectons I.LN - largest node BLN - bisected node Page 2 of 3
+
+--- Page 3 ---
+LN - lynph nodes Summary of Sections: Part 1:  MESENTARY, OVERLYING RIGHT RENAL TUMOR; BIOPSY Block Sect. Site PCs 1 fsc 1 Part 2: GEROTA'S FASCIA, ANTERIOR; BIOPSY Block PCs Sect. Site 1 fSc 1 Part 3:  KIDNEY, LOWER POLE AND CAVAL LYMPH NODES, PARTIAL NEPHRECTOMY Block Sect. Site PCs 1 BLN 1 2 LLN 2 1 LN 1 8 M 8 2 RS 2 6 T 6 Intraoperative Consultation: Note:  The diagnoses given in this section pertain only to the tissue sample examined at the tine of the intraoperative consuitation 1) FROZEN SECTION DIAGN MESENTERY OVERLYING RIGHT ANTERIOR KIDNEY TUMOR BENIGN FIBROUS TISSUE PERMANENT DIAGNOSIS: SAME 2) FROZEN SECTION DIAGNOSIS: SP:ANTERIOR GEROTA FASCIA PERMANENT DIAGNOSIS: SAME Page 3 of 3 END OF REPORT
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+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 /cs-0-3 1 oucthl, N0S 8500/3 SURGICAL PATHOLOGY REPORT Site: busst, Nos c5o.9 1/3up h Patient: Specimen #: FMP/SSN: DOB/Age/Sex: Race: WHITE Taken: Location: Received: Physician(s) : Reported: SPECIMEN : A: SENTINEL NODE RIGHT BREAST B: RIGHT BREAST TISSUE FINAL DIAGNOSIS: A. SENTINEL NODE, RIGHT, AXILLARY: ONE (1) LYMPH NODE NEGATIVE FOR METASTATIC CARCINOMA BY H&E AND IMMUNOHISTOCHEMISTRY. B. BREAST, RIGHT, NEEDLE-LOCALIZED EXCISION: TUMOR TYPE: INFILTRATING DUCTAL CARCINOMA, NOS, MULTIFOCAL. NOTTINGHAM GRADE: III/III (G3) NOTTINGHAM SCORE: 8/9 (Tubules= 3, Nuclei- 3, Mitoses= 2; mitotic count 13 per 10 HpF at. 40x power - field diameter = 0.63 mm) TuMoR size (greatest dimension, measured grossly): MASS #1: 1.0 CM MASS #2: 0.5 CM MASS #3: 1.2 CM TUMOR NECROSIS: PRESENT MICROCALCIFICATIONS: PRESENT ASSOCIATED WITH CARCINOMA AND IN THE MEDIA OF VESSELS (MEDIAL CALCIFIC SCLEROSIS). VENOUS / LYMPHATIC INVASION: NOT IDENTIFIED MARGINS: INVASIVE (B7) AND IN SITU (B4,7) CARCINOMA PRESENT LESS THAN 0.1 CM FROM THE MEDIAL MARGIN (YELLOW). INTRADUCTAL COMPONENT: DUCTAL CARCINOMA IN SITU, NUCLEAR GRADE 3 (SOLID AND COMEDO TYPES) LYMPH NODES: SEE SPECIMEN "A" ESTROGEN RECEPTORS: : POSITIVE (95%) PROGESTERONE RECEPTORS: : POSITIVE (95%) HER 2 NEU by IHC: NEGATIVE (1+) PATHOLOGIC STAGE: pT1c NO MX ADDITIONAL PATHOLOGIC CHANGES: FIBROCYSTIC CHANGES, MAMMOMARKS IDENTIFIED. commenr: Three clearly separate tumor foci have been identified grossly. and on the accompanying specimen radiograph, favoring the designation of 'multifocal' rather than one large tumor. UUID:4264989A-2904-4005-A78C-AC801792ADEB TCGA-A2-A0EU-01A-PR Redacted Page 1 Continued on Next Page ILY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 2 ---
+FOR OFFICIAL USR ONLY - PERSONAL DATA - PRIVACY ACT OP 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: FINAL DIAGNOSIS (continued) : ** Report Electronically Signed Out ** CLINICAL DIAGNOSIS AND HISTORY: year old female undergoing needle localized lumpectomy of the right breast with sentinel node biopsy. GROSS DESCRIPTION: A. Received fresh, labeled with the patient's name, designated "SENTINEL NODE RIGHT BREAST" is a 2.5 x 2.0 x 1.0 cm 1rregular portion of soft tissue. Sectioning reveals a single, pink-yellow, lymph node measuring 1.5 x 0.5 x 0.3 cm. The lymph node is bisected. A matched. section of the specimen is submitted in cassette A1 is submitted in for the cbcp protocol. The specimen is entirely submitted as follows: Cassette Key: A1: Lymph node. A2: Adipose tissue. B. Received fresh, labeled with the patient's name, designated "RIghT BREAsT TIssue" is an irregular portion of soft tissue oriented as follows: short stitch is superior aspect, long stitch is. lateral aspect, and double stitch is the deep aspect. The specimen measures 8.5 cm from medial to lateral, 8.5 cm from superior to inferior, and 2.5 cm from anterior to posterior. The specimen is received with an accompanying radiograph, and two embedded localization wires. The specimen is inked as follows: superior aspect is inked in blue, inferior aspect is inked in green, the medial aspect is inked in yellow, the lateral aspect is inked in red, the anterior aspect is inked in orange,. and the posterior aspect is inked in black. Serial sectioning reveals three fairly well defined, pink-white masses. Mass #1 measures 1.0 x 0.7 x 0.5 cm and is located 0.7 cm from the deep margin. Mass #2 measures 0.5 x 0.3 x 0.3 cm, and is located 0.5 cm anterior to mass #1 in approximately the same plane of tissue, and coming to within 0.2 cm of the anterior and lateral margins. Mass #3 measures 1.2 x 1.0 x 0.6 cm, and is located 1.0 cm medial to mass #1 and mass #2 coming to within 0.2 cm of the anterior margin. The remainder of the specimen is composed of lobulated,. yellow-tan, adipose tissue admixed with minimal fibrous tissue. No Page 2 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 3 ---
+ACT0F197 SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION (continued) : additional lesions are identified. At the time of processing, the specimen will have spent 51 hours fixing in formalin. The specimen is. submitted as follows:. Cassette Key: Bl: Representative section of mass #l. B2: Margins of specimen submitted in cassette B1. B3-B4: Representative sections from mass #2. B5: Normal appearing breast tissue adjacent to cassette B4.. B6: Representative section of mass #3 with nearest margin. B7: Representative section of mass #3 with nearest margin. B8-B9: Additional margins from mass #1. B11-B14: Additional margins from mass #2. B15: Area of fibrous tissue medial to mass #3. Matched sections of specimen is submitted in cassettes B1, B5, and B7 are submitted in for the clinical breast care project protocol. Page 3 End of Report FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
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index 0000000000000000000000000000000000000000..3dc2df3cd735e2101353504d13330fd31ae8718a
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+page 1 / 1 Department of Cancer Pathology copy No. Date: Examination: Histopathological examination (cito). Internal invoice No. Value of diagnostic procedure Examination No.: 1  Patient: XXX PEseL: XXX Age: Gender: F Material: Multiple organ resection -- left breast with axillary tissues. 1cD-0-3 Unit in charge' cancnomx, nfittrnttng ouct,nos 85oof3  Physician in charge: Siu: braot, os c50.9 hs yJ1s|rl Material collected on: Material received on: Expected time of examination: 5 working days. Clinical diagnosis: Examination performed on: Results of immunohistochemical examination:. Estrogen receptors foond in over 75% of neoplastic cell nuclei. Progesterone receptors found in over 75% of neoplastic cell nuclei. HER2 protein stained with HercepTestTM by DAKO. Negative reaction in invasive cancerous cells ( Score = 1+ ) Compliance validated by: Examination performed on: Macroscopic description: Left breastsized 20.2 x 17.2 x 5.8 cm removed along with axillary tissues sized 8 x 5 x 3 cm and a skin flap of 21,4 x 15,4 cm. Weight 900 g. Tumour sized 4.3 x 6.2 x 2.2 cm found in the upper outer quadrant, placed 1.2 cm from the upper boundary, 0.1 cm from the base and 0.5 cm from the skin. Skin retraction 3 cm in diameter in the upper outer quadrant. Microscopic description: Carcinoma invasivum - NHG3 (3 + 3 + 3/20 mitoses/10 HPF - visual area 0.55 mm). Infiltratio carcinomatosa cutis mammae. Mamilla sine laesionibus. Lesions of the type mastopathia fibrosa in the glandular tissue.. Axillary lymph nodes Metastases carcinomatosae in iymphonodis (No v/VII). Infiltratio telac perinodalis. Histopathologic diagnosis Carcinoma ductale invasivum mammae sinistrae, Invasive ductal carcinoma of the left breast: Metastases carcinomatosae in lymphonodis (No XvII). Cancer metastases in the lymph nodes (No XVII) (NHG3; pT3; pN2a). UUID:880A4D38-40CS-46C3-8EE7-36539DD647730 CONTACT YOUR DOCTOR WITH TCGA-D8-A1X6-01A-PR Redacted
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diff --git a/output/text/6b0dd320-df68-465b-b0d6-18461a85c539.txt b/output/text/6b0dd320-df68-465b-b0d6-18461a85c539.txt
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index 0000000000000000000000000000000000000000..6feee35549ca49055d76034fa44d6b2c4c8f2c12
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+- LAB RESULTS SURG PATH REPORT PATH#: IcD-0- 3 COLLECTION DATE/TIME: D 8o7s/3 1st Specimen collected on ceQQ N6S Accessioned on FINAL DIAGNOSIS Pathologist: Sute: Jneu Nss Cs2.9 1) DEEP RIGHT TONGUE BASE (EXCISION): NEGATIVE FOR TUMOR. 2) LEFT HARD PALATE (EXCISION) : NEGATIVE FOR TUMOR. OJ -/24/13 3) DEEP SKULL BASE (EXCISION): NEGATIVE FOR TUMOR. 4) LEFT NASOPHARYNX (EXCISION): NEGATIVE FOR TUMOR. 5) DEEP MIDLINE HARD PALATE (EXCISION): NEGATIVE FOR TUMOR. UUID: FB282F08-6047-4844-90A4-AA4B04911ED6 TCGA-BB-A6UO-01A-PR Redacted 6) RIGHT SOFT PALATE (EXCISION): NEGATIVE FOR TUMOR. 7) LEFT VALLECULA (EXCISION) : NEGATIVE FOR TUMOR. 8) PARAPHARYNGEAL SPACE FAT (EXCISION) : NEGATIVE FOR TUMOR. 9) LEFT PHARYNX (EXCISION): NEGATIVE FOR TUMOR. 10) MIDLINE HARD PALATE (EXCISION) : NEGATIVE FOR TUMOR. 11) TONGUE, LEFT MANDIBLE AND POSTERIOR PHARYNGEAL WALL (COMPLETE SUBTOTAL GLOSSECTOMY) : SPECIMEN TYPE: COMPOSITE SUBTOTAL GLOSSECTOMY AND HEMIMANDIBULECTOMY TUMOR SITE: ORAL CAVITY (TONGUE) TUMOR SIZE: GREATEST DIMENSION: 7.0 CM HISTOLOGIC TYPE: CARCINOMAS OF UPPER AERODIGESTIVE TRACT: SQUAMOUS CELL CARCINOMA, CONVENTIONAL HISTOLOGIC GRADE: G2: MODERATELY DIFFERENTIATED EXTENT OF INVASION (7th Edition AJCC): PRIMARY TUMOR (pT): MANDIBULAR BONE AND INTO SOFT TISSUES OF THE FLOOR OF THE MOUTH) SPECIFY: NUMBER EXAMINED: 30 NUMBER INVOLVED: 3 REGIONAL LYMPH NODES (pN): pN2b: METASTASIS IN MULTIPLE IPSILATERAL LYMPH NODES, NOT MORE THAN 6 CM IN GREATEST DIMENSION EXTRACAPSULAR EXTENSION OF NODAL TUMOR: PRESENT DISTANT METASTASIS (pM): pMX: CANNOT BE ASSESSED MARGINS: MARGINS UNINVOLVED BY TUMOR (SEE ALSO PARTS 1-1O) TUMOR APPROACHES WITHIN 1 MM OF THE POSTERIOR PHARYNGEAL SOFT TISSUE SPECIMEN EDGE (PART 11)  Unofficial lab results - do not file in patient chart. ***. *** Contact medical records for official chart copy. UNLESS OTHERWISE NOTED ON THE DETAIL PAGE, ALL LAR RESULTS PERFORMED AT: Page 1 of 2
+
+--- Page 2 ---
+- LAB RESULTS VENOUS/LYMPHATIC (LARGE/SMALL VESSEL) INVASION:S INDETERMINATE NEURAL INVASION: PERINEURAL AND INTRANEURAL INVASION ARE PRESENTS 12) LYMPH NODE, LEFT AXILLA (EXCISION): ONE (1) LYMPH NODE AND ASSOCIATED FIBROADIPOSE TISSUE, NEGATIVE FOR TUMOR. 13) LYMPH NODES, LEET NECK LEVEL 2B (EXCISION) : SIX (6) LYMPH NODES AND ASSOCIATED FIBROADIPOSE TISSUE, NEGATIVE FOR TUMOR. 14) LYMPH NODES, RIGHT NECK LEVEL 1B (EXCISION) : TWO (2) LYMPH NODES AND ASSOCIATED FIBROADIPOSE TISSUE, NEGATIVE FOR TUMOR. 15) DEEP SKULL BASE (EXCISION) : BENIGN SKELETAL MUSCLE, BONE AND FIBROADIPOSE TISSUE, NEGATIVE FOR TUMOR. CELLULAR TRILINEAGE MARROW WITH FULL MATURATION. 16) PARAPHARYNGEAL SPACE (EXCISION) : BENIGN SKELETAL MUSCLE AND FIBROADIPOSE TISSUE, NEGATIVE FOR TUMOR. 17) LYMPH NODES, LEFT NECK LEVELS 1-3 (EXCISION): LEVEL 1: BENIGN FIBROADIPOSE TISSUE. LEVEL 2: METASTATIC SQUAMOUS CELL CARCINOMA INVOLVING ONE (1) OF TWO (2) LYMPH NODES (1.5 CM), WITH EXTRANODAL EXTENSION. LEVEL 3: METASTATIC SQUAMOUS CELL CARCINOMA INVOLVING TWO (2) OF SEVENTEEN (17) LYMPH NODES (0.6 AND 0.3 CM); EXTRACAPSULAR EXTENSION IS NOT IDENTIFIED. See for official report. Reported by:. Final Report Signed on /3 *** Unofficial lab results - do not file in patient chart. *** *** Contact medical records for official chart copy. *** Case is (cir UNLESS OTHERWISE NOTED ON THE DETAIL PAGE. ALL LAB RESULTS PERFORMED AT: Page 2 of 2
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+Path Report Final SURGICAL PATHOLOGY REPORT ACCESSION NO. Final Diagnosis(es): (A) Lymph node, pericaval, biopsy: One lymph node negatlve for. metastatlc malignancy (0/1). (B) Lymph node, hepatic artery, blopsy: One lymph node. negative for metastatic malignancy (0/1). (C) Bile duct margin, blopsy: Negative for malignancy. (D) Pancreas margin, blopsy: Negalive for malignancy. (E) Antrum, duodenum, head of pancreas, common blle duct, and proximal jeJunum, Whipple: Ductal adenocarcinoma, pancreatic, moderately differentiated, pT3N1MX (seo synoptlo report). Synoptic Report: Specimen: Head of pancreas. Procedure: Pancreatlcoduodenectomy (Whipple resectlon), partial. pancreatectomy. Tumor Site: Pancreatic head. Tumor Size: Greatest Dimension: 2.8 cm. Additional Dimensions: 1.8 x 2.2 cm. Histologic Type: Ductal adenocarcinoma. Histologic Grade: G2: Moderately differentiated. Mleroscopic Tumor Extension: Tumor Invades duodenal wall.. Margins: Margins uninvolved by Invasive carcinoma. Lymphvascular Invaslon: Present. Perineural Invasion: Present. Pathologic Staging: Primary Tumor: pT3: Tumor extends bayond the pancreas but without Involvement of the cellac axis or the superlor. mesenteric artery. Reglonal Lymph Nodes: pN1. Regional lymph node metastasis. Number of Lymph Nodes Examined: 12 Number of Lymph Nodes Involved: 1 al Pathologic Findings: Chronic pancreatilis. The gross description and all microscopic slldes have been 1 pathologist Specimon(s) Received: A: Per! caval lymph node B: hepatic artery lymph node C: Bile duct margin D: Pancreas margin Printed trom: Defautt
+
+--- Page 2 ---
+E: Antrum, duodenum, head of pancreas, common blle duct, and proximal jejunum Clinical History: Adenocarcinoma of the head of pancreas.. (C) Stitch marks marginal.. Intraoperative Consullation: FSA1: Perlcaval lymph node: No carcinoma(1 block), FSB1-FSB2: Hepatio artery lymph node: No carcinoma (2 blocks) FSC1: Bile duct margin: No carcinoma (1 block). FSD1: Panoreatic marain: No carcinoma (1 block). Gross Description: (A) (pericaval lymph node) Recalved fresh for frozen section evaluation of metastatlc disease Is a 0.8 x 0.5 x 0.3 cm. red-yellow, fatly tissue fragment. The specimen is bisected and submitted in toto in cassette F$A1.. (8) (hepatlc artery lymph node) Recelved fresh for frozen sectlon evaluation of metastatic disease is a 2.0 x 0.8 x 0.5 cm, tan, rubbery lymph node. The speclmen is blsected and submitted in toto in cassettes FSB1 and FSB2 (C) (bile duct margin) Received fresh for frozen seclion evaluation for margins is a 1.2 x 1.0 x 0.4 cm, tan-red, donut shaped tissue fragment. The specimen is submitted in toto in FSC1. (D) (pancreas margin) Recelved fresh for frozen section evaluatlon for margins is a 2.0 x 1.2 x 0.5 cm, tan-red, fragment of pancreas. The speclmen Is submitted In toto In FSD1. (E) (antrum, duodenum, head of pancreas, common bile duct and proximal Jejunum) Received fresh and subsequently placed in formalin after sectlons were taken for Tumor Bank are a previously opened antrum of stomach (13.3 x 5.7 x 0.3 cm wall thlckness), duodenum (21.5 x 7.1 x 0.7 cm wall thickness), pancreas (5.3 x 2.7 x 2.4 cm), bite duct (5.0 cm In length by 1.0 cm in dlameter), and gallbladder (9.3 x 2.7 x 1.7 cm). The posterlor aspect of the pancreas has been inked black, the anterior yellow, uncinate margin green, vascular notch margln purple, and pancreatic duct margin red. The bile duct is opened longitudinally revealing dilatallon of the bile duct, A longltudinal sectlon through the blle duct and duodenum reveal no gross invasion of pancreatic tumor into the ampulla or duodenum. Sectioning through the pancreas reveals a firm, tan leslon within the head of the pancreas thal measures 1.8 x 2.2 x 2.8 cm. The tumor appears to be invading into the duodenal wall but not into the duodenal
+
+--- Page 3 ---
+mucosa. The lesion is located approximately 1.0 cm away from the uncinate margin, approximately 1.8 cm away from the pancreatic duct margin, and at least 1.0 cm away from the posterior pancreatic margin. The antral stomach mucosa is tan and rugated without lesions or ulcers. The duodenal mucosa is tan and rugated with congestion of the distal aspect. No Ieslons or masses are Identified In the duodenum. The serosal surface of the gallbladder is gray-purple and glistening. The gallbladder Is opened revealing a wall thickness of 0.3 cm and a mucosa that is velvety, purple-gray. No stones or lesions are identlfled. Palpatlon and dissectlon reveal seven tan potential perigastric lymph nodes that range in slze from 0.3 to 0.7 cm In greatest dimenston. One tan potential lymph node is found inferior to the pancreas measuring up to 0.6 cm In greatest dimension. Slocks submitted: E1 - pancreatlc duct margin. E2-E3 - proximal slomach margin. E4-E5 - distal small bowel margin. E6-E7 - unclnale margin E8-E9 - longitudinal section through ampulla and duodenum E10-E12 - representative sections through pancreatic tumor E13 - tumor to stomach E14 - representative section through stomach. E15 - representative sectlon through duodenum. E16 - reprosentative seclions through grossly uninvolved Dancreas E17 - representative section of the gallbladder including a cross section of the cystlc duct. E18 - seven potentlal perigastric lymph nodes E19 - one potentlal inferlor pancreatic lymph node. Microscopic Description: Complete mlcroscopic evaluallon has been performed..
+
+--- Page 4 ---
+Unless otherwise stated in the report, all tissue tested for. ERPR by lHC, Har2 by IHC and/or HER2 by FISH have been fixed as per ANP.22998 for a minimum of 6 hours and a maximum of 48 hours. ER, PR, Kl-67, p53 are reported as a semi-quantitative percentage of positively stalned nuclel. Her-2/neu and EGFR are scored as follows: No staining at all is scored as (0), weak, incomplete membrane staining in any proportion of cells is scored as (1+), less than slrong but complete staining In any proportion of cells or complete strong staining In less than 30% of cells is scored as (2+), and strong complete staining In more that 30% of cells is scored as (3+). All studies are performed on tissue fixed in 10% neutral buffered formalin and embedded in paraffin unless otherwise stated in the report..
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+Surgical Pathology Report Name: Case #: DOb: Collected: Gender: Recelved: MrN: 3 Reported: Location: Copy To: Physician: Pathologic Interpr tation: 1cs-0-3 A. Sentinel node #1, left side, CT : :ouch prep: Carcnomr, mifltnsHxy duct nos 85oc/3 - No tumor seen in one lymph noge (0/1). Sit: brsst, NOs C50.9 - Immunohistochemistry for Keratin to follow. 8.  Left/breast 1 stitch superior, 2 stitches lateral: - Invasive, moderately differentiated ductal carcinoma, intermediate nuclear grade, 0.5 cm. - Specimen margins are negative (see tumor summary). - Fibroadenoma, 0.5 cm. c. Sentinel node #1, right side CT - No tumor seen in two lymph nodes (0/2). UUID: 042304AE-706A-4033-A97F-3765A6AEC649 - Immunohistochemistry for Keratin to follow. TCGA-Ew-A1P3-01A-PR Redacted D. Non-sentinel lymph node right side: - No tumor seen in one lymph node (0/1). E. Sentine! lymph node #2, right side, CT #. touch prep: - No tumor seen In one tymph node (0/1). - Immunohistochemistry for Keratin to follow. F. Right breast additional superior flap: - No tumor seen in adipose tissue. G. Right breast 1 stitch superlor, 2 stitches lateral: - Invasive, moderately differentiated ductal carcinoma, intermediate nuclear grade, 2.5 cm, extending within 0.1 cm of the anterior specimen margin (see tumor summary). TumoR SummAry "b": Specimen Type: Mastectomy Lymph Node Sampling: Sentinel tymph node(s) onty Laterallty: Left Tumor Site: Upper inner quadrant Size of Invasive Component: Greatest dimension: 0.5 cm Histologic Type: invasive ductal carcinoma Histologic Grade: Tubule Formatlon: Moderate 10% to 75% (score =2) Nuclear Pleomorphism: Moderate increase in size, etc (score =2) Mitotic Count: 10 to 20 mitoses per 10 HPF (score = 2) Total Nottingham Score: Grade II: 6-7 points Pathologic Staging (pTNM) Primary Tumor: pT1a Regionai Lymph Nodes: pN0 Number examined: 1 Number Involved: 0 Distant Metastasis: pMX Margins: Margins uninvolved by invasive carcinoma Venous/Lyrnphatic Invasion: Absent E,ute.. TUmOR SUMmaRy "G": Specimen Type: Mastectomy Lymph Nodo Sampling: Sentinel lymph node with axillary dissection Laterality: Right. Tumor Site: tower outer quadrant
+
+--- Page 2 ---
+SURGICAL PaTHOL Report Size of Invasive Component: Greatest dimension: 2.5 cm Histologic Type: Invasive ducta! carcinoma Histologic Grade: Tubule Formation: Minimal less than 10% (score =3)  Nuciear Pleomorphism: Moderate increase in size, etc (score = 2) Mitotic Count: Less than 10 mitoses per 10 HPF (score =1) Total Nottingham Score: Grade II: 6-7 points Pathologic Staging (pTNM) Primary Tumor: pT2 Regional Lymph Nodas: pN0 Number examined: 4 Number involved: 0 Distant Metastasis: pMXd Margins: Margins uninvoived by invasive carcinoma Distance from closest margin: 1.0 mmd Specify which margin: Anterior. Venous/Lymphatic Invasion: Absentd ***Electronically Signed Out By*** spectic reagents (ASRs) yatidateo by our iaboratory (Her 3 Payo, H. pytori, Hecore). Thees ASRs are cHnicaly uaetu ndicators that dk NOTE: Some inmunohistochemical antibodies are anelyt cal stains are used not require FDA approvel. These cones #e used: ID5=ER, PgR 636-PR, A485=HER2, H-11EGFR, CCH2/DDG9=CMV, F39.4.1=AR and HPV by /SH. A# wnmunohistoche Wth Formaln or molaculer fixed, pwamin embedded tissue. Detection is by LSAB. The resuts are read by a pathologier as postihe or negarine. . MD As the attending pathoiogie, I attest thet i: (0 Examined the relevart preparation(s) for the speckmen(s); and (i) Rendered the diagnosis(es). Procedures/Addenda Date Ordered: Status: Signed Out Addendum Date Complete: : Date Reported: Addendum Dlagnosis A.  Immunohistochemistry for Keratin is negative for tumor.. C.  Immunohistochemistry for Keratin is negative for tumor. E.  Immunohistochemistry for Keratin is negative for tumor. MD Intraoperative Consultation A (FS): No malignancy seen in one lymph node (0/1) C (FS): No malignancy seen in two lymph nodes examined (0/2). E (FS): No malignancy seen in one lymph node examined (0/1). MD Clinical History: Page 2 of 4
+
+--- Page 3 ---
+SURGICAL PATHOL Report Patient is a. . female with right infiltrate ductal carcinoma. Specimen(s) Received: A: Sentinel node #1, left side, ct : ouch prep (FS) B: Left Breast 1 stitch superior, 2 stitches lateral, fresh C: Sentinel node #1, right side ct 1 (FS) D: Non-sentinel lymph node right side E: Sentinel lymph node #2, Right side, ct # touch prep (FS) F: Right breast additionai superior flap - perm G: Right breast 1 stitch superior, 2 stitches lateral , fresh Gross Description:. A. Received fresh and labeled *sentinel node #1, left side, ct touch prep (FS)" is a segment of tan-yellow, fibroadipose tissue measuring 2.5 x 1.1 x 0.5 cm. Cassettes are submitted as follows: 1 One iymph node bisected submitted in toto for frozen section 2 Remainder adipose tissue submitted in toto in one cassette B. Received fresh and labeled *teft breast 1 stitch superior, 2 stitches lateral* is a mastectomy specimen, which measures 22.0 x 19.0 x 4.0 cm and weighs 790.0 grams. The specimen has an attached ellipse of pale-tan skin with areola and nipple measuring 9.0 x 4.5 cm. The skin and nipple are unremarkable. The specimen is oriented by one stitch superior and two stitches lateral. Surgical margins are inked as follows: superior anterior margin inked in green and the remaining margins are inked in black. Serial section through the specimen revealed one suspicious area of pale-pink induration consistent with previous biopsy site. The indurated area measures approximately 1.1 cm in greatest dimension and is located in the upper inner quadrant at 11 to 12 o'clock, 0.8 cm from the superficial margin, 0.9 cm from the deep margin, 3.0 cm from the superior margin, 16.0 cm from the inferior margin, 3.5 cm from the medlal margin and 12.0 cm from the latera! margin. An area of interparenchyma hemorrhage is also identified in the inner upper quadrant, approximately 5.0 cm from the nipple. An additional suspicious area of pale pink induration with a granular, cut surface is identifled in the lower outer quadrant at approximately 4 o'clock. The second suspicious area is located 2.6 cm away from the deep margin, 1.8 cm away from the superficial margin, 10.5 cm away from the superior margin, 8.5 cm away from the inferior margin, 4.5 cm away from the lateral margin and 13.5 cm away from the medial margin. Cassettes are submitted as follows: 1 Superficial margin 23 Deep margin  Superior margin 4  Inferior margin 5  Medial margin 6 Lateral margin 7-13 Suspicious area and surrounding parenchyma submitted in toto 14 Section of the hemorhagic area. 15 Sections of the second suspicious area 16 Section of the nipple 17 Representative section of uninvolved breast parenchyma in the upper outer quadrant. 18 Representative section of uninvolved parenchyma in the upper inner quadrant. 19 Representative section of uninvolved parenchyma in the lower inner quadrant. 20  Representative section of uninvolved parenchyma in the lower outer quadrant. c. Received fresh and labeled "sentinel node #1, right side. ' is a segment of tan-yellow, fibroadipose tissue measuring 2.0 x 1.3 x 1.0 cm. Examinations of the specimen revealed two possible lymph nodes. Cassettes are submitted as follows: 1 One lymph node bisected and submitted for frozen section 2 One lymph node bisected submitted for frozen section. 3 Remainder of the adipose tissue submitted for frozen section in one cassette. D. Received in formalin and labeled *non-sentinel lymph node right side~is a segment of tan-white, soft tissue measuring 1.8 x 0.7 x 0.4 cm. The specimen is bisected and submitted in toto in one cassette. Page 3 of 4
+
+--- Page 4 ---
+SURGICAL PATHOL Roport such prep (Fs)" is a segment of tan-yellow, E Received fresh and labeled "sentinel lymph node #2, right side, ct fibroadipose tissue measuring 2.1 x 1.1 x 0.6 cm. Examinations of the segment revealed one lymph node. Cassettes are submitted as follows: 1 One lymph node bisected and submitted for frozen section 2 F. Received in formalin and labeled *right breast additional superior flap" is a segment of tan-yellow, fibroadipose tissue measuring 6.0 x 3.7 x 1.6 cm. The specimen is received unoriented. One of the surface is rough, irregular and appears to face the previous resection site. The surface was inked in orange. The opposite surface was inked in black. Serial sections through the specimen revealed no suspicious areas. Representative sections submitted in six cassettes. G. Received fresh and labeled *right breast 1 stitch superior, 2 stitches lateral" is a mastectomy specimen, which measures 23.0 x 22.0 x 4.0 cm and weighs 670.0 grams. There is an ellipse of skin with areola and nipple, which measures 9.0 x 3.5 x 0.2 cm. The nipple measures 1.2 x 1.1 cm. The skin is unremarkable. The section margins are inked as foliows: superior, green and all other margins are inked in black. Serial section through the specimen revealed an area of pale. pink induration measuring 2.5 x 1.4 x 1.2 cm and is located in the lower outer quadrant. A firm area is present at the  superficial margin and is located 3.0 cm from the inferior margin, 2.5 cm from the deep margin and 7.0 cm from the superior margin. The remainder of the parenchyma consists of unremarkable fibroadipose tissue with approximately 70% adipose tissue and 30% stroma. No other suspicious areas were identified. Cassettes are submitted as follows: 1 Anterior margin 23 Inferior margin Deep margin 4 Lateral margin 5  Superior margin 6 Medial margin 7-13 Area of induration submitted 14  Representative section of uninvolved parenchyma in the upper outer quadrant. 15  Representative section of uninvolved parenchyma in the upper inner quadrant. 16  Representative section of uninvoived parenchyma in the lower inner quadrant. 17 'ative section of uninvoived parenchyma in the lower outer quadrant near the lesion. ICD-9(s): 174.2 174.5 Page 4 of 4
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diff --git a/output/text/6b5b0b3e-1c07-4eed-bcf4-1068717b517e.txt b/output/text/6b5b0b3e-1c07-4eed-bcf4-1068717b517e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fd3dc611ba6b8ae5b73d1813e2e23adf03f04484
--- /dev/null
+++ b/output/text/6b5b0b3e-1c07-4eed-bcf4-1068717b517e.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Ics-0-3 Carcinonn infiHtnatrg duct,N0s 85o0f3 Sip: brest, Nos c50.9 lw 5/19/u UUID:976C6F9E-DDCB-42F4-BD2C-A4D715396847 TCGA-D8-A27F-01A-PR Redacted page 1 / 1 copy No. Date: Examination: Histopathological examination Internal invoice No. Value of diagnostic procedure Examination No.: Patient: XXX peseL: XXX Age: Gender: F Material: Multiple organ resection --right br@ast with axillary tissues. Unit in charge:  Physician in charge: prof. N/A Material collected on: Material received on: Expected time of examination: up to 8 working days. Clinical diagnosis: Cancer of the right breast. . Examination performed on: Results of immunohistochemical examination:. No estrogen receptors found in the neoplastic cell nuclei. No progesterone receptors found in the neoplastic cell nuclei. HER2 protein stained with HercepTestTM by DAKO. Negative reaction in invasive cancerous cells ( Score = 1+ ). dr Compliance validated by:  dr Examination performed on: Macroscopic description: Right breast gized 19 x 14 x 4 cm removed along with axillary tissues sized 8 x 7 x 3 cm and a skin flap of 17 x 8 cm. Tumour sized 2.5 x 2.3 x 2.0 cm in the upper outer quadrant, located 1.7 cm from the upper boundary, 0.2 cm from the base and 0.8 cm from the skin. Microscopic description:. Carcinoma ductale invasivum NHG3 (3+3+3: 24 mitoses/10 HPF - visual area: 0.55mm). Glandular tissue outside the tumour showing lesions of the type mastopathia fibrosa, adenosis simplex.. Axillary lymph nodes: Sinus histiocytosis lymphonodorum (No XI). Histopathological diagnosis: Carcinoma ductale invasivum mammae dextrae. Invasive ductal carcinoma of the right breast (NHG3, pT2, pNO). dr Compliance validated by: dr
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diff --git a/output/text/6b6dddc0-3158-4d4a-ad8e-4a562ed0b5bd.txt b/output/text/6b6dddc0-3158-4d4a-ad8e-4a562ed0b5bd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0cfc7b3999612321a8219d2c0a9b9261afc63390
--- /dev/null
+++ b/output/text/6b6dddc0-3158-4d4a-ad8e-4a562ed0b5bd.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:3E4717BA-E9AE-45F9-9696-F8928D9FCECCE TCGA-A2-A3KD-01A-PR Redacted FOR OPFICIAL USE ONLY - PERSONAL DATA - PRIVAS SURGICAL PATHOLOGY REPORT Patient: Specimen #: FMP/SSN: DOb/Age/Sex: (Age: : )F Race: Taken: Location: Received: Physician(s) : Reported: SPECIMEN: A: RIGHT SENTINEL NODE #1 B: RIGHT BREAST SENTINEL NODE #2 C: RIGHT BREAST LUMPECTOMY /cd-c-3 circi ome,infiPt^stny mu cNouw 848o/3 FINAL DIAGNOSIS: Site+hrust, Nos. Cs0.? 12/13/ A. LYMPH NODE, RIGHT AXILLA SENTINEL #1, BIOPSY: ONE LYMPH NODE POSITIVE FOR MICROMETASTASIS (A1, LARGEST FOCUS, 0.27 MM - measured micrOsCopically); ISOLATED TUMOR CELLS ALSO PRESENT IN EXTRACAPSULAR LYMPHATIC SPACES. - ONE LYMPH NODE POSITIVE FOR ISOLATED TUMOR CELLS (A2). ONE LYMPH NODE NEGATIVE FOR TUMOR BY H&E LIGHT MICROSCOPY AND CYTOKERATIN IMMUNOHISTOCHEMISTRY (A3). B. LYMPH NODE, RIGHT AXILLA SENTINEL #2, BIOPSY: - ONE LYMPH NODE NEGATIVE FOR TUMOR BY H&E LIGHT MICROSCOPY AND CYTOKERATIN IMMUNOHISTOCHEMISTRY; HOWEVER, ISOLATED TUMOR CELLS ARE PRESENT IN EXTRACAPSULAR LYMPHATIC SPACES. C. BREAST, RIGHT, LUMPECTOMY:  WELL-DIFFERENTIATED (GRADE I/III) INFILTRATING MUCINOUS (COLLOID) CARCINOMA. * NOTTINGHAM HISTOLOGIC SCORE: 4 OUT OF 9 (Tubule formation = 2; Nuclear pleomorphism = 1; Mitotic activity = 1). * TumoR sIzE: 4.0 cM (measured grossly).  TUMOR NECROSIS OR CALCIFICATIONS: ABSENT.  VENOUS/LYMPHATIC INVASION: FOCI HIGHLY SUSPICIOUS FOR LYMPHATIC INVASION. * MARGINS: POSITIVE. INFILTRATING CARCINOMA IS PRESENT AT THE INKED BLUE (SUPERIOR, E.G., SLIDE C2). ORANGE (ANTERIOR, E.G., SLIDE C3), RED (MEDIAL, E.G., SLIDE C8), AND BLACK (DEEP, E.G., SLIDE C11) TISSUE EDGES. * IN SITU COMPONENT: FOCAL DUCTAL CARCINOMA IN SITU, LOW NUCLEAR GRADE (DCIS, GRADE 1); SOLID AND FOCAL CRIBRIFORM TYPES. * LYMPH NODES: ONE OUT OF FOUR SENTINEL LYMPH NODES POSITIVE FOR MICROMETASTASIS (please see part "A" and 1 "B"). ESTROGEN RECEPTORS: POSITIVE (>95%, pleaSe see report) PROGESTERONE RECEPTORS: POSITIVE (9O%, pleaSe see repOrt k HER2NEU by IHC: NEGATIVE (Score 1+, please see report Page 1 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 2 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA -  PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: FINAL DIAGNOSIS (continued): * PATHOLOGIC STAGE: pT2N1mi( ADDITIONAL PATHOLOGIC FINDINGS: * STROMAL SCLEROSIS AND FOCAL MICROCYST FORMATION. * FOCAL PRIOR BIOPSY SITE CHANGES. k* Report Electronically Signed Out ** CLINICAL DIAGNOSIS AND HISTORY: Right breast cancer -year-old female. PRE-OPERATIVE DIAGNOSIS: None provided. POST-OPERATIVE DIAGNOSIS: None provided. GROSS DESCRIPTION: A: Received fresh, labeled with the patient's name. nd designated, "Right' Breast Sentinel Node #1" consists of three pink-tan lymph nodes measuring 0.3 cm, 0.8 x 0.5 x 0.4 cm, and 1.5 x 1.2 x 0.5 cm in greatest dimension. Sectioning the larger lymph node reveals pink-red otherwise unremarkable parenchyma. The specimen is entirely submitted as follows: A1- one lymph node, bisected; A2- one lymph node; A3- one lymph node. A matched section of A2 is submitted in ocr for. protocol. Time in formalin: B: Received in formalin, labeled with the patient's name and designated, "Right Breast Sentinel Node #2" consists of a 0.4 x 0.3 x 0.3. cm tan lymph node. The lymph node is bisected and submitted in its entirety. Time in formalin:. C: Received fresh, labelled with the patient's name and designated, "Right Breast Lumpectomy" consists of an ovoid portion of firm, yellow-tan breast tissue oriented with a short stitch-superior; and long stitch-lateral. The specimen measures 6.5 cm from superior to inferior; 5.5 cm from medial to lateral and 2.0 cm from anterior to deep. The specimen is inked as follows: superior-blue; inferior-green;. medial-red; lateral-yellow; anterior-orange; and deep-black. Serial sections reveal a firm, gritty, pink-tan mass measuring 4.0 x 3.5 x 1.5 Page 2 Continued on Next Page. FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 3 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION (continued) : cm. The mass show well defined borders along the superior portion of the specimen with patchy, ill defined distribution throughout the remainder of the specimen, involving approximately 75% of the cut surface. The mass. abuts the superior, anterior, deep, and medial margins. The surrounding breast tissue is dense, pink and white fibrous tissue. No other mass lesions are identified.  Representative sections are sequentially. submitted from superior to inferior as follows: C1-c2- mass with superior margin; c3-c5- mass with additional margins; C6- adjacent normal; c7- mass with additional margins; c8- mass with additional margins; c9- mass with lateral margin; c1o- mass with additional margins; c1i- mass with additional margins; C12- inferior margin. Matched sections of c3,c5,c7, and c9-c11 are submitted in Ocr and paraffin for ' protocol. Time in formalin: EED jxf13/11 Page 3 End of Report FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
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diff --git a/output/text/6b71bbe7-c65c-4446-889f-4613ecb7a5f0.txt b/output/text/6b71bbe7-c65c-4446-889f-4613ecb7a5f0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4066530f211593f4d795e5e58f30bdf53c4fc418
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+tSS ID: TSS ID. OC iD Date of Procurement: Gross Description: Lump with the tumor of 1.2 x 1.3 cm in size. 1co-0-3 cavcioma, infiltnstng duct,nes 850c/3 Fatty tissue lymph nodes are dense, hyperemic. Sth: buast, Nos c5o.9 4/8/ b Microscopic Description: Infiltrating duct carcinoma, G2.. Ten dissected lymph nodes demonstrate reactive changes. Diagnosis Details: Tumor Features: Unknown, Tumor Extent: T1 tumor size 2 cm or less, Venous Invasion: Absent, Margins: Absent, Treatment Effect: Comments:d Formatted Path Report: BREAST TISSUE CHECKLIST Specimen type: Lumpectomy Specimen size: Not specified Tumor site: Upper outer quadrant Tumor size: 1.2 x 1.3 x 0 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinoma Histologic grade: Moderately differentiated UUID: 26140CA5-AF22-47DD-BE48-C3C7DE07E5DB Redacted TCGA-E9-A1RA-01A-PR Tumor extent: Not specified Lymph nodes: 0/10 positive for metastasis (Axillary 0/10) Extracapsular invasion of the lymph nodes: Not specified Margins: Uninvolved  Nottingham Histologic Score Tubule formation: Not specified. Nuclear pleomorphism: Not specified lus 4f8/11
+
+--- Page 2 ---
+TSS IC Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified. Comments: None Laterality: Left, upper outer quadrant.
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diff --git a/output/text/6b87964f-e950-4329-b4e1-6671706ccafd.txt b/output/text/6b87964f-e950-4329-b4e1-6671706ccafd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..50b55f436d5359a676fbb5e72f39c873462bddf2
--- /dev/null
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+
+--- Page 1 ---
+page 1 / 1 Department of Cancer Pathology copy No. 3 Date: Examination: Histopathological examination Examination No.: Patient: XXX PESEL: XXX Age Gender: Material: 1. Total organ resection -- specimen from the colon. Unit in charge:  Physician in charge: Material collected on: Material received on. Expected time of examination: Clinical diagnosis: Cancer of the transverse colon. Examination performed on Macroscopic description: A 12 cm length of the large intestine with periintestinal fat tissue sized 12.5 x 4.5 x 5 cm. Ulcerous tumour sized 6.0 x 4 x 1.6 found in the mucosa. The lesion surrounds 100% of the intestine circumference and narrows its Iumen, is Iocated 3 cm from one of the incision lines and 3.6 cm from the opposite one. Minimum side margin is 1.3 cm.. Microscopic description: Adenocarcinoma tubulare (G2).. Infiltratio carcinomatosa tunicae muscularis propriae et telae adiposae pericolicae. Incision lines clear of neoplastic lesions. Lymphonodulitis reactiva No XVI.. Histopathological diagnosis: Adenocarcinoma tubulare coli. Tubular adenocarcinoma of the colon. (G2, Dukes B, Astler-Coller B2, pT3, pNO). Compliance validated by: CONTACT YOUR DOCTOR WITH THIS REPORT!
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diff --git a/output/text/6b8b2afc-6d5f-4e29-942d-1fa309f81a73.txt b/output/text/6b8b2afc-6d5f-4e29-942d-1fa309f81a73.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b381c5f0503e2273270d7fe45d546f2c43344ac3
--- /dev/null
+++ b/output/text/6b8b2afc-6d5f-4e29-942d-1fa309f81a73.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+TcD-o-3 ercrsmo,urstilol NsS 8/20)3 Sample # CscF Ste. Cntein waIlg bladder. Gender: Male C73 DOB: mtt Race: Native Hawaiian/Other Pacific Islander Smusoppero lesur & Report Date: blodder Cb7.8 Pathology Report: QsJ 7hj!3 9262DABE-98EE-4544-8907-124CDE5197C0 Surgical Pathology Report TI-01A-PR Redacted FINAL PATHOLOGIC DIAGNOSIS A. Right pelvic lymph node; dissection: - One of ten lymph nodes, positive for metastatic urothelial carcinoma (1/10). - Lymph nodal tumor focus measures 2.0 cm, with extranodal tumor extension. B. Left pelvic lymph node; dissection:. - Eleven lymph nodes, no tumor (0/11). C. Urinary bladder; cystoprostatectomy: - Bladder with high grade urothelial carcinoma invading thru the muscularis propria and extending into the perivesical tissue and seminal vesicle, see pathologic parameters. - Posterior margin is positive for urothelial carcinoma. - Prostate with prostatic adenocarcinoma, see pathologic parameters. Urothelial Carcinoma Pathologic Parameters 1. Tumor type: Invasive urothelial carcinoma. 2. Grade of tumor: High grade. 3. Depth of invasion: Extravesicular soft tissue and seminal vesicle. 4. Tumor distribution: Solitary, 5.5 cm involving dome, right lateral wall, anterior wall and posterior wall.. 5. Ureteral margins: Negative for tumor. 6. Distal urethral margin: Negative for tumor. 7. Soft tissue margin or serosa: Positive for urothelial carcinoma (1.3 cm) 8. Lymph nodes: Positive for tumor (1/21). 9. pTNM: pT4b,N1,MX, R1. Effective January 1, 2010 this Checklist utilizes the 7th edition TNM staging system for Bladder of the American Joint Committee on Cancer (AJCC) and the International Union Against Cancer (UICC).
+
+--- Page 2 ---
+Radical Prostatectomy Pathologic Parameters 1. Gleason Score: 3+4=7 2. Perineural Invasion: Present. 3. Tumor Location: Peripheral zone - right and left. 4. Tumor Volume Estimate: 15%. 5. High-grade P.I.N.: Multifocal. 6. Seminal Vesicles: Negative for prostate carcinoma. 7. Extraprostatic Extension: Absent. 8. Peripheral Margin: Positive for tumor (right anterior, 0.1 mm).. 9. Distal (apical) Margin: Negative for tumor. 10. Proximal (basilar) Margin: N/A 11. Regional Lymph Nodes (right and left): Negative for prostate carcinoma (0/21). 12. pTNM: pT2c,N0,MX, R1. Effective January 1, 2010 this Checklist utilizes the 7th edition TNM staging system for prostatectomy of the American Joint Committee on Cancer (AJCC) and the International Union Against Cancer (UICC). Interpretation performed by the Attending Pathologist and reviewed with the Resident/Fellow,[] M.D., Ph.D. Electronically Signed Out by [] MD Clinical History: The patient is a.  year-old male with history of high-grade urothelial carcinoma invasive into muscularis propria undergoing cystectomy and lymph node dissection. Specimens Received: A: Right pelvic lymph node B: Left pelvic lymph node C: Bladder, vas deferens, Gross Description: The specimens are received in three containers each labeled with the patient's name and medical record number. A. The first container is additionally identified as, "right pelvic lymph. node". Received in formalin are multiple fragments of yellow, lobulated. fibroadipose tissue measuring 6.5 x 5.8 x 2.4 cm in aggregate. Multiple rubbery
+
+--- Page 3 ---
+lymph nodes are identified ranging from 0.3-5.5 cm in greatest dimension. Representative sections of the specimen are submitted as follows: A1: Multiple candidate lymph nodes. A2: One lymph node, bisected A3-A5: One lymph node, trisected A6-A10: One lymph node B. The second container is additionally identified as, "left pelvic lymph node". Received in formalin are multiple fragments of yellow, lobulated fibroadipose tissue measuring 7.5 x 5 x 1.9 cm in aggregate. Multiple rubbery lymph nodes are identified ranging from 0.2-6 cm in greatest dimension. Representative sections of the specimen are submitted as follows: B1: Multiple candidate lymph nodes B2: 2 lymph nodes, bisected B3: One lymph node bisected B4-B5: One lymph node, bisected B6-B9: One lymph node, sectioned C. The third container is additionally identified as, "bladder, vas deferens". Received fresh and placed in formalin is a 301.8 g, 16 x 10.5 x 3.6 cm cystoprostatectomy specimen with attached mesenteric fat. The bladder measures 7.5 x 7 x 2.5 cm. The right ureteral stump measures 5 x 0.3 cm and the left 3 x 0.5 cm, and both demonstrate patent lumina. The prostate measures 4.2 x 3 x 2.9 cm. The right seminal vesicle measures 2.8 x 1.1 x 0.6 cm and the right vas deferens 8 x 0.5 cm. Detached vessels are also present measuring 5.2 and 5.5 cm in length by 0.3 cm in diameter The left seminal vesicle measures 2.4 x 1 x 0.5 cm and the left vas deferens 12 x 0.5 cm. Plastic tubing is present in the bladder. There is disruption of the junction of the prostate and bladder along the right side of the specimen. The urethral stump is flush with the prostate apex. The right half of the prostate and bladder is inked blue and the left half is inked black. The prostate is opened anteriorly along the urethra and continued superiorly through the bladder in a Y-shaped incision. The prostate is serially sectioned from apex to base to reveal an ill-defined, yellow-tan, firm lesion measuring 1.8 x 0.9 x 0.6 cm in the right prostate measuring 0.1 cm from the margin. The bladder demonstrates a tan, fungating, ulcerated 5.5 x 5.5 cm mass involving the dome, right lateral wall, right half of the anterior wall and some of the right posterior wall. The right ureteral orifice is involved by the mass. Serial sectioning reveals ill-defined tumor invasion into the adipose tissue to a depth of 1.4 cm, extending to 0.2 cm of the inked margin. The remainder of the mucosa is tan-brown, edematous, and glistening with a uniform 0.2 cm wall thickness. The bilateral ureteral orifices are identified and probe patent. The perivesicular fat is extensively dissected for lymph nodes, but none are found. Representative sections are submitted as follows: C1: Left ureteral margin C2: Right ureteral margin C3: Urethral and prostatic apical margin
+
+--- Page 4 ---
+C4-C6: Representative prostate, right half (with lesion) C7-C9: Representative prostate, left half. C10: Right vas deferens and seminal vesicle C11-c12: Left vas deferens and seminal vesicle C13-C17: Mass (with deepest invasion in C14) C18: Uninvolved left wall. C19: Mass and right ureteral orifice. C20: Additional distal urethral margin
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diff --git a/output/text/6ba3faf5-5fa5-458c-900e-8575f69597e0.txt b/output/text/6ba3faf5-5fa5-458c-900e-8575f69597e0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b4d45b451b96a677ec61b3f7250dc8307de3edff
--- /dev/null
+++ b/output/text/6ba3faf5-5fa5-458c-900e-8575f69597e0.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+1cs-0 -3 Carcnoma,mfjl+rntwg ouct, N0S 8500|3 1/8/10 lw Sir wdu: bruast, Nos  c50.9 TSS: SPECIMENS: UUID:1FE4EB4C-FEF8-486A-B39D-6F9F023FDAC4 TCGA-E2-A15D-01A-PR Redacted A. RIGHT BREAST CANCER B. SENTINEL L.N. #1 RIGHT AXILLA C. SENTINEL L.N. #2 RIGHT AXIL;LA D. SENTINEL L.N. #3 RIGHT AXILLA E. SENTINEL L.N. #4 RIGHT AXILLA SPECIMEN(S): A. RIGHT BREAST CANCER B. SENTINEL L.N. #1 RIGHT AXILLA C. SENTINEL L.N. #2 RIGHT AXIL;LA D. SENTINEL L.N. #3 RIGHT AXILLA E. SENTINEL L.N. #4 RIGHT AXILLA GROSS DESCRIPTION: A. RIGHT BREAST CANCER Received fresh labeled with the patient's identification and "right breast needle localization" is a previously inked 53g. 6 x 5 x 4cm needle iocalized lumpectomy with radiograph. Ink code: anterior-yellow, posterior-black, superior-blue,. inferior-orange, medial-green, lateral-red. Specimen is serially sectioned from lateral to medial into 8 slices revealing a 2.5 x 2.3 x 1.5cm tan white firm well circumscribed mass, 0.6cm from the closest inferior margin in slices 2-7. A surgical clip is identified in slice 5. A portion of the specimen is submitted for tissue procurement. Representatively submitted: A1-A2: lateral margin slice 1 A3-A5: slice 2 A6-A8: slice 3 A9-A15: slice 4 A16: slice 5 with clip ID A17-A18: slice 6 A19-A20: slice 7 A21: medial margin. B. SENTINEL L.N. #1 RIGHT AXILLA Received fresh is a tan pink lymph node 1.2 x 1 x 1cm. The specimen is sectioned and a touch prep is taken. Toto B1. C. SENTINEL L.N. #2 RIGHT AXILLA Received fresh is a tan pink lymph node 0.8 x 0.6 x 0.5cm. The specimen is bisected and a touch prep is taken. Toto. C1. D. SENTINEL L.N. #3 RIGHT AXILLA  Received fresh is a tan pink lymph node 1.2 x 1 x 0.8cm. The specimen is bisected and a touch prep is taken. Toto. D1. E. SENTINEL L.N. #4 RIGHT AXILLA  Received fresh is a tan pink lymph node 1.4 x 1 x 0.6cm. The specimen is bisected and a touch prep is taken. Toto. E1. DIAGNOSIS: A. BREAST, RIGHT, WIDE LOCAL EXCISION: - INVASIVE DUCTAL CARCINOMA, SBR GRADE 1, MEASURING 2.2-CM - INTERMEDIATE NUCLEAR GRADE, DUCTAL CARCINOMA IN SITU, CRIBRIFORM TYPE WITH CENTRAL NECROSIS - SURGICAL RESECTION MARGINS NEGATIVE FOR TUMOR  - DCIS PRESENT WITHIN 0.15-CM FROM INFERIOR SURGICAL RESECTION MARGIN  - BIOPSY SITE CHANGES WITH FIBROSIS AND GRANULATION TISSUE - SEE SYNOPTIC REPORT. B. LYMPH NODE, SENTINEL #1, RIGHT AXILLA, EXCISION:E - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1). C. LYMPH NODE, SENTINEL #2, RIGHT AXILLA, EXCISION:E - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1) D. LYMPH NODE, SENTINEL #3, RIGHT AXILLA, EXCISION:E - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1). E. LYMPH NODE, SENTINEL #4, RIGHT AXILLA, EXCISION:E
+
+--- Page 2 ---
+- ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1) SYNOPTIC REPORT - BREAST Specimen Type: Excision Needle Localization: Yes - For mass Laterality: (Right Invasive Tumor: Present Multifocality:No WHO CLASSIFICATION invasive ductal carcinoma, NOS 8500/3 Tumor size: 2.2cm Tumor Site: Not specified Margins: Negative Distance from closest margin: 0.4cm inferior Tubular Score: 2 Nuclear Grade: 2 Mitotic Score: 1 Modified Scarff Bloom Richardson Grade:e Necrosis: Absent Vascular/Lymphatic Invasion: None identified Lobular neoplasia:  None Lymph nodes: Sentinel lymph node only. Lymph node status: Negative 0/4 DCIS present  Margins uninvolved by DCis 0.15-cm from inferior DCIS Quantity:Estimate 30% DCIS Type: Cribriform DCIS Location:Associated with invasive tumor Nuclear grade: Intermediate Necrosis: Present ER/PR/HER2 Results ER: Positive PR: Positive HER2: Negative by FISH Performed on Case: Pathological staging (pTN): pT 2 N O CLINICAL HISTORY: None provided. PRE-OPERATIVE DIAGNOSIS: Right breast cancer. INTRAOPERATIVE CONSULTATION: A. GROss v^MINATiON: Right breast- mass is 2.5cm and 0.6cm from the closest inferior margin. Diagnosis called to Dr. at  by Dr. TPB-TPC-TPD-TPE: SLN #1-4: Negative for carcinoma. Diagnosis called to Dr. at by Dr. ADDENDUM: ONCOTYPE DX BREAST CANCER ASSAY RESULTS: Recurrence Score: 17 CLINICAL EXPERIENCE: Patients with a recurrence score of: 17 in the clinical validation study had an average rate of Distant Recurrence at 10 years of 11% ER Score: 9.8  Positive PR Score: 8.4 Positive Her2 Score: 9.5 Negative Interpretation: ER Negative < 6.5 Positive >= 6.5 PR Negative < 5.5 Positive >= 5.5
+
+--- Page 3 ---
+Her2 Negative <10.7 Positive >=11.5 Equivocal = 10.7 - 11.4 See separate report for further information. Test performed at:. Gross Dictation:e  Microscopic/Diagnostic Dictation: Pathoioaist. Final Review: Patholaxiet. Final: Pathologist,. Addendum: Pathologist, Addendum Final: Pathologist,.
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diff --git a/output/text/6bdd5fb7-200d-4406-b428-841580ae6d38.txt b/output/text/6bdd5fb7-200d-4406-b428-841580ae6d38.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f33f5a489ca50fd276d781d0e6b7d5976909a454
--- /dev/null
+++ b/output/text/6bdd5fb7-200d-4406-b428-841580ae6d38.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+/cs-0-3 carcnona, cluct, mnhi9tratiny 85oof3 Sife Cd: sust Nos c5s.9 7 Patient:. AP Surgical Pathology: Final. Acc#. Surg Path CLINICAL HISTORY: Probable metastatic breast CA - year-old white female presenting with left femur fracture ? pathologic, has large 6 cm breast mass in left breast. GROSS EXAMINATION:S "Left breast biopsy", in formalin. An irregular fragment of yellow. A. fibro-adipose tissue measuring 5 x 2.5 x 2 cm in approximate dimensions. The specimen has previously been sectioned and a portion submitted for ER-PR evaluation. The margins of the specimen were not inked as the surgeon felt. this was unnecessary.  The specimen is sectioned and submitted in toto in. Blocks A1 through A6. DIAGNOSIS: "LEFT BREAST BIOPSY": 1. INTRADUCTAL CARCINOMA, SOLID AND COMEDO-TYPES, AND INFILTRATING DUCT CARCINOMA (5 CM IN GREATEST DIMENSION), NSABP HISTOLOGIC GRADE 2 OF 3, NUCLEAR GRADE MODERATELY DIFFERENTIATED. 2. VASCULAR INVASION BY CARCINOMA IS IDENTIFIED. Verified by: (ElectronicSignature) Date Signed:- UUID: 291884D2-FDFD-4C98-BA19-1A0824AB868F TCGA-B6-A0I9-01A-PR Redacted esult fo! I of 1
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diff --git a/output/text/6bef50d1-609d-484c-8923-3d208b8686b6.txt b/output/text/6bef50d1-609d-484c-8923-3d208b8686b6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b14038bc9f67b7280a2a3113dcffea1af1d40978
--- /dev/null
+++ b/output/text/6bef50d1-609d-484c-8923-3d208b8686b6.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID: 2CBB70B5-A5D3-4385-9E05-5DD19243E127 TCGA-2Z-A932-01A-PR Redacted Pathology Report Genderr Servicer Received: Reporceds, Submitting Fhysicians's IaD63 atnologstr Intraop' Fat holegtetx Fertormtng .Phyeiciant 'Orsinsmd, ypapislary nensI seQQ CLINICAL HI STORY 8Q6t|3 YEAR-OLD FEMALK. Sut: Yislney NtS PREOPERATIVE DIAGNCSIS: C64.9 LEFT HENAL MASS SERCIMEN TYPE (S) : ) y/28/14J ALEFT FRRINEPHRIC FAT B.LEFT KIDNEY CLETIETHR FINAL DIAGNCSIS. A. LEFT PERINBPIRIC. FAT: Finroad pose tlssue, negat ive for malignancy. B. LEETXIDNEYNEPHRRCTCMY Papiilary renal cell carcinoma, type. 2, (see Key Patnologicaz Findtnga and. conmertt. ComMenrs Immunchiatochemical scainswitn 3cequate ccntrols were pextormed cn Dlock Isneled al co turtner investigate.tnsa caae. rne necplastic celis anow insunoreactivity Witn visentin, Amncn, cnib, ana caurexin. They are negative witn c-xit. LEFT 1THRI9: A portion orbone, conatste w1tn a segmerot 1birosJagnoala KEY PATHOLOCICAL FINDINGS Specimens tet. kidney Tumor ayper Papliiary renai cell carcinoma, type.3. Nuclear grade: Grade 1 Fattern.ot.growthr Sclin. Tumor sire: 3c Renalcapaulenvaslon: Nct Identiried. nvaston ot Gernca's Faecta. Not. Identisied. Renal vein invaaignr Net prenent. Negative cor malignancy Nen-reopsstie kidney: Pocal m:id cnrsnia pyelonepnr:t:s. Adrenal gland Not applacable: Lymph rsaess Not. appilcanle.. 3t.holog0sage NXMX M.D. tne. attendirg patnotogist,.personaiy reviewed the entire OER RELATED.CLENICAL LATA:
+
+--- Page 2 ---
+GROSS.DESCRIPTION: A. Specimen isrecatved rraan,lareled *perinephric rat snd consiats ct 1 7.0 x 3.5 xls cm. aott.yelow-can,Lobulatedlittletragsent or adipose tissue.No palpable noduies are grossly appreciated. cut surtace is grosely unremarxable. Representative sectfona sre suraitted. Al cnrougn A3. Spacimen n ix Jarelen *iett kidney This specimen ia received yreeh and consists or a kidney wnien nas a minszal amcunt of attached pertcephsic adipose txsave.. The apecimen wesgnas0.9 grana and mezsurea 10.0 x 4.5 x 4-0cm. Tha capauie of the kidrey Ia intact, and sarred witn black irx,Attacred ta tne kldneyis.a.6.d cm Iengtn cr ureter whch upon cpening grosaly.appeare unremarkable. Tne.specimen is biaected and revesied an tii-derined, rirm,, gray- yeliow masa whicn Is located in the-inrerior pole.or tnespecimen easuring 3.x2.5 x..5 cm. Grpsslytne msadoes nct appear to nvolve the.xenal capauie.or renal perinepnr adipcse tisaue tne renal pelvie.and collectingsyatem grosaly appears rrae or tusor Trerenal srtery and vein are sdentiriad,. opened"ard grosaiy are rree ot tusor. .. grossiy unrazarxabie. No adrennl glands are aicached to the specimen. On sectioning. the iele.o: perinephric adipcae ttssue, no Iympn nodeg are Aeolates Adnitcnal necroais (apprcxlma:ely Aot) . A xepresentative secticn or the mass As subnicted to the Tieaue Proturenent Laboratory.Reproaencative.firsecn:cne are submitted as: Hi: Ureter and vesaels.3x-s5: Tumor ancwn in relationsnip to adjacent. tisaue. H6: Renal pevis. B7 Grogsiy unremarkable ranal paranchyma. C. Specimen C is sateled *portion o lert itn ribt. Tre speclsen is received rresh ana cora ats ot resected portion ot bcne snicn is greasiy canaiscent witn a segment crrib easaring Ssx.1.5.x gs cm.tne.specsen grcasly appeared uuremarkable.No sectiors are sutxitted, gross only. w 13|Ly
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diff --git a/output/text/6c353a44-3f02-431d-a2ce-a64a9d1701fa.txt b/output/text/6c353a44-3f02-431d-a2ce-a64a9d1701fa.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1c5c21cd391065f3a0240bbbc1ff8b68fe2ac338
--- /dev/null
+++ b/output/text/6c353a44-3f02-431d-a2ce-a64a9d1701fa.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Ics-u- Procedure Date: Carcinonn, nfltmatinq duct,N0s 85vsf3 Procedure Physician: S its: 3rot Nos cS0.9 Attending Physician/Copies To:e /20 UUID:C5D116FF-3193-48A0-869C-D98831D9976A0 tcgA-Bh-AiFB-01a-Pr Redacted Patient history: * DATE of LMP: DATE OF LAST DELIVERY:S PRE-OP DIAGNOSIS: RT BREAST CA POST-OP DIAGNOSIS: SAME OPERATIVE PROCEDURE: RT SENTINEL LYMPH NODE BIOPSY, RIGHT AXILLARY DISSECTION, RT SEGMENTAL MASTECTOMY, EXCISION OF LEFT FLANKS CLINICAL HISTORY: QMATERIAL SUSMITTED: A) RIGHT SENTINEL LYMPH NODE, PROCUREMENT BY SURGICAL PROCEDURE B) RIGHT AXILLARY LYMPH NODE(S), PROCUREMENT BY SURGICAL PROCEDURE C) RIGHT AXILLARY LYMPH NODE(S), PROCUREMENT BY SURGICAL PROCEDURE #2 D) RIGHT BREAST BIOPSY/TISSUE, PROCUREMENT BY SURGICAL PROCEDURE E  RIGHT AXILLA, PROCUREMENT BY SURGICAL PROCEDURE F) RIGHT NEW MARGIN TISSUE, PROCUREMENT BY SURGICAL PROCEDURE nedial G) LIPOMA, PROCUREMENT BY SURGICAL PROCEDURE left flank INTRAOPERATIVE CONSULTATION:S FRozen sEcrioN: Sentinel Node #l, one lymph node identified 1.0 x 0.5 x 0.5 cm. Touch Prep Diagnosis: Suspicious Frozen Section Diagnosis: Positive for Metastatic Carcinoma Right Breast - history of infiltrating carcinoma, 7.0 x 9.0 x 4.0 cm. Specimen inked and oriented. Tumor identified 2.2 x 2.4 x 2.4 cm. Tumor closest to the medial margin; all other margins are free of tumor grossly (less than 1.0 mm). FINAL DIAGNOSIS: FINAL DIAGNOSIS: ACAFS)RIGHT SENTINEL NODE #1: LYPH NODE WITH METASTATIC CARCINOMA TUMOR DORS NOT EXTEND BEYOND LYMPH NODE CAPSULE B) RIGHT SENTINEL NODE #2: - LYMPH NODE, NEGATIVE FOR TUMORS C) RIGHT SENTINEL NODE #3: LYMPH NODE WITH METASTATIC CARCINOMA TUMOR DOZS NOT EXTEND BRYOND LYOH NODE CAPSULE DCY) RIGHT SKGENTAL PASTECTOMY AND NEW MEDIAL MARGIN: IN ILTRATING AND INTRADUCTAL CARCINOMA, 2.2 BY 2.4BY 2.4CM CROSS RBER NOTTINGHAM SCORE 4/9 (TUBULES-1, NUCLEI=2, MITOSES-1) INTRADUCTAL CARCINOMA IS CRIBRIFOR4 TYPE AND COMPRISES APPROXDOATELY St OE TUMOR VOLUNE TUMOR ASSOCIATED MICROCALCIFICATION IDENTIFIED - VASCULAR SPACE INVOLVEMENT IS NOT PROMINENT SURGICAL MARGINS FRRE OF TUMOR IN PLANES OF SECTION - FIBROCYSTIC CHANGES WITH MICROCALCIWICATIONS E) RIGHT AXILLA: FIFTEEN LYMPR NODES NEGATIVE FOR TUMOR (O/15) G) MATURE ADIPOSE TISSUE, CONSISTENT WITH LIPONA NOTe: sR/pR immunoperoxidase assay and Her-2/Nau testing will be performed on block "p3".
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diff --git a/output/text/6c57edef-1063-4dbd-a4dd-30be6c32f472.txt b/output/text/6c57edef-1063-4dbd-a4dd-30be6c32f472.txt
new file mode 100644
index 0000000000000000000000000000000000000000..468d0e736936075662192e155f98f12999fe1b5d
--- /dev/null
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@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+Clinical Diagnosis & History: CRC of ascending colon. Specimens Submitted: 1: sp: Right colon, partial colectomy 2: Sp Portion of omentum DIAGNOSIS: 1. SP: Right colon, partial colectomy:. Tumor Type: Adenocarcinoma Histologic Grade:  Moderately differentiated r Location:d Cecum Size: Length is 6.5 cm Width is 10 cm  Maximal thicknesa is 2.0 cm Tumor Budding: Absent Increased Tunor Infiltrating Lymphocytes: Absent Precursor Lesions: Tubulovillous adenoma Deepest Tumor Invasion: Muscularis propria Gross Tumor Perforation: Not identified Lymphovascular Invasion: Not identified Laxge Venous Invasion.  Not Identified Perineural Invasion: Not identified Surgical Marging: Free of tumor Polyps/Mucosa Dysplasia (away from the carcinoma): Not Identified Non-Neoplastic Bowel: Continued on next page *
+
+--- Page 2 ---
+Unremaxkable Appendix: Unremaxkable Lymph Nodes: Numbex with metastasis: 0. Total number examined: 33 Tumor deposits in pericolorectal soft tissue: Not Identified Tumor Staging (AJcc 7th Edition) : pT2 (Tunor invades muacularis propria) Lymph Node Stage (AJCc 7th Edition): NO (No regional lymph node metastasis) 2 PORTION OF OMENTUM, EXCISION: BENIGN MATURE ADIPOSE TISSUE. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. 1).The specimen is received fresh, labeled "Right colon" and consists of a segment of terminal ileum, cecum with attached appendix and ascending colon. The terminal ileum measuxes nine cm in length and five cm in circumference at the proximal resected margin. The xemaining. colon measures 24 in length. with a circumference of s.5 cm at the distal resected margin. The attached appendix measures six cm in length and averages 0.7 cm in diameter. The appendiceal and intestinal serosa is pink tan and smooth.  Focally hemorrhagic lobulated yellow tan adipose tigsue spans the length of the specimen measuring up to tive cm in thickness.. The specimen is opened to reveal a large gessile lesion measuring 6.5 cm in length, 10 cm in width, and to 2 cm in thickness. The mass is located in the cecum, eight cm from the proximal margin and 18 cm from the distal margin. Sectioning reveals probable invasion into the submucosa. There is queationable muscularis propria invasion and the tumor does not appear to' invade through the muaculazis propria. The depth of invasion ig 0.2 cm grossly.  The remaining mucosa is tan with normal folds. The attached adipose tissue is thoroughly examined and all identified lymph nodes are submitted. Representative sections of the specimen are submitted for permanent sections and fox Tps. Summary of sections:. P - proximal margin shave D distal margin shave T tumor  appendix representative sections ** Continued on next page *
+
+--- Page 3 ---
+Page 3 of 4 RS -repregentative LN - Lymph nodes BLN - bisected lymph nodes TLN-txisected lymph node SLN-one lymph node sectioned 2). The specimen is received fresh, labeled "Portion of omentum." It consists of a 16.0 x 11.0 x 0.5 cm portion of lobulated adipose tissue consistent with omentum. Serial sectioning reveals a lobulated surface. Representative sections are submitted. Summary of sections: - omentum Summary of Sections: Part 1: SP: Right colon, partial colectomy Block Sect. Site PCo 1 1 3 5 BLN 4 1 9 LN 27 1 1 1 RS 3 SLN 10 r 10 1 TLN 3 Part 2: Sp: Portion of omentun Block Sect. Site PCs 2 0 Procedures/Addenda: Addendum Date Ordered: Date Complete Date Reported Addendum Diagnosis #1) SETE: LARGE BOWEL IMMUNOHISTOCHEMICAL: STAINING FOR DNA MISMATCH REPAIR PROTEINS HAS BEEN PERFORMED PER CLINICAL REQUEST. THE RESULTS ARE AS FOLLOWS: MLH1: STAINING PRESENT IN TUMOR MSH2 t STAINING PRESENT IN TUMOR ** Continued on next page **
+
+--- Page 4 ---
+Page 4 of 4 MSH6 : STAINING PRESENT IN TUMOR PMS2 : STAINING PRESENT IN TUMOR CONCLUSION: IMMUNOHISTOCHEMICAL STAINING FOR THE TESTED DNA MISMATCH REPAIR PROTEINS IS RETAINED IN THE TUMOR. Some of the immunohistochemistry and Ish tests were developed and their performance characteristics were determined by the Department of Pathology. Administration. The FoA has determined that such clearance or approval is not necesaary. These tests are used for clinical purposes. They should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of. as * End of Report
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diff --git a/output/text/6c58f0ee-0299-4004-97a0-33029484b81f.txt b/output/text/6c58f0ee-0299-4004-97a0-33029484b81f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..cbd5105c3e948cd56d61310d27f2035cce3b93a2
--- /dev/null
+++ b/output/text/6c58f0ee-0299-4004-97a0-33029484b81f.txt
@@ -0,0 +1,24 @@
+
+--- Page 1 ---
+UUID:D5DE4BB3-81AC-44CB-9336-060F324C7A2F TCGA-OL-A66-01A-PR Redacted Sample # : FINAL PATHOLOGIC DIAGNOSIS A. Lymph node, sentinel #1, right axillary, excision: - One lymph node, negative for metastatic carcinoma (0/1) - Biopsy site changes identified.. zeD-6-3 B. Lymph node, sentinel #2, right axillary, excision: U 8524/3 - One lymph node, negative for metastatic carcinoma (0/1). QJ s/ish3 C. Lymph node, sentinel #3, right axillary, excision: - One lymph node, negative for metastatic carcinoma (0/1). D. Lymph node, sentinel #4, right axillary, excision: - One lymph node, negative for metastatic carcinoma (0/1) E. Breast, right, partial mastectomy: - Invasive lobular carcinoma, see breast pathologic parameters. - Margins of excision free of tumor, distance to the closest margin >2 mm to superior and anterior.. - Lobular intraepithelial neoplasia (LCiS), classic type. - Atypical ductal hyperplasia.. - Previous biopsy site identified with extensive fat necrosis.
+
+--- Page 2 ---
+- Flat epithelial atypia, focally associated with microcalcifications. - Sclerosing adenosis, focally associated with microcalcifications. -Microcalcifications in benign ductal and stroma - Fibrocystic changes with cystic apocrine metaplasia F. Breast, additional superior medial margin, excision: -Focal atypical ductal hyperplasia -Lobular intraepithelial neoplasia (ALH/LCiS) - Focal flat epithelial atypia. - Sclerosing adenosis focally associated with microcalcifications. - Microcalcifications in benign ductules and stroma - Fibrocystic changes with cystic apocrine metaplasia. -Duct ectasia Breast Pathologic Parameters Specimen E: Breast, right, partial mastectomy 1. Invasive carcinoma: A. Size: Gross measurement: 1.6 x 1.5 x 1.4 cm B. Composite histologic (modified SBR) grade II -Architecture: 3 -Nuclear grade: 2 - Mitotic count: 1
+
+--- Page 3 ---
+C. Associated lobular intraepithelial neoplasia (LCiS): Within main mass (forming <5% of tumor volume) Extending away from main mass 3.Excisional biopsy margins: Free of tumor - Invasive carcinoma > 2 mm from anterior and superior margins - Additional margins greater than 3 mm away. 4.Blood vessel and lymphatic invasion:Not definitively identified 5.Axillary lymph nodes:Negative for tumor (0/4 6.Special studies (see ): Strong expression of ER in 90% of invasive tumor nuclei - Strong expression of PR in 50% of invasive tumor nuclei -Her2/neu antigen (FISH) Not amplified.Ratio 1.5 7.pTNM:pT1c,NOsnMX Clinical History: The patient is an year old female with a history of biopsy proven grade II ILC of the right breast who undergoes right breast needle localization
+
+--- Page 4 ---
+lumpectomy and right axillary sentinel node dissection. Most recent breast imaging on showed in the right breast at the 10 o'clock position an. irregularly shaped heterogenous enhancing mass with irregular margins and metallic clip artifact at mid depth measuring 1.4 x 1.2 x 1.2 cm representing. the biopsy proven malignant lesion.Posterior to that main mass was a focal. non-mass like enhancement measuring 1.6 x 1.1 cm suspicious for extension of the disease with a total extent of 2.8 cm. Comment Part E: The tumor reveals a mixed ductal and lobular morphologic appearance,. however, immunohistochemical stains for E-cadherin were performed on representative areas and supports the presence of a lobular carcinoma.. Case presented at multidisciplinary breast conference on. Specimens Received: A: Right axillary sentinel node#1 B: Right axillary sentinel node #2
+
+--- Page 5 ---
+C: Right axillary sentinel node #3 D: Right axillary sentinel node #4 E: Right breast partial mastectomy F: Additional superior medial margin Gross Description: The specimen is received in six containers each labeled with the patient' s name and medical record number. A.Container A is further designated as'1. Right axillary sentinel node #1. Received fresh and placed in formalin is a 1.5 x 1.2 x 1.0 cm firm, rubbery Iymph node that is dissected and entirely submitted in cassette A1. B. Container B is further designated as '2. Right axillary sentinel node #2.' Received fresh and placed in formalin is a 0.7 x 0.6 x 0.4 cm tan, rubbery lymph node candidate that is entirely submitted in cassette B1. C. Container C is further designated as '3. Right axillary sentinel node #3.' Received fresh and placed in formalin is a 0.9 x 0.7 x 0.4 cm tan, rubbery lymph node candidate. It is entirely submitted in cassette C1 D. Container D is further designated as '4. Right axillary sentinel node #4. Received fresh and placed in formalin is a 0.6 x 0.5 x 0.2 cm tan, rubbery lymph
+
+--- Page 6 ---
+node candidate that is entirely submitted in cassette D1 E. Container E is further designated as'5. Right breast partial mastectomy with the paper work additionally designating 1 stitch = lateral. Received fresh and placed in formalin is a 99.5 gram, 8.5 cm (superior to inferior) x 10.0 cm (medial to lateral) x 3.5 cm (anterior to posterior) breast lumpectomy specimen on a radiographic grid with a corresponding x-ray film. There is a metallic clip located in the center of a spiculated irregularly shaped mass which corresponds to C3-C4, D3-D4 and D5. The metallic clip is located in D4. There is a questionable extension of the mass into grids E3-E4. A wire extends through the center of this mass entering at B5 and terminating at F1. The specimen is received with two sutures, long designating lateral and short designating superior. The margins are inked as follows: superior blue, inferior green, anterior black, posterior red, lateral violet and medial yellow.The specimen is serially sectioned from lateral to medial into 14 slices to reveal a 1.6 x 1.5 x 1.4 cm firm, white poorly circumscribed mass extending from slice 6 to slice 9.There is a metallic clip found on the center of this mass in slice 8.The mass approaches the anterior margin within O.3 cm (slice 9) and the posterior margin within 0.6 cm (slice 7).Additionally, the lesion is 3.5 cm from the inferior margin and O.7 cm from the superior margin. The mass is greater than 2 cm from both the medial and lateral margins. The wire terminates in slice 11. The remainder of the breast tissue consists of grossly unremarkable yellow, lobulated adipose tissue. Representative sections are submitted as follows:
+
+--- Page 7 ---
+E1: mass with clip (slice 8) showing approach to posterior and superior margins. E2-E3: anterior margin from slice 8 E4-E5: mass in slice 7 showing closest approach to posterior margin E6-E7: mass in slice 6 demonstrating biopsy site changes E8: inferior margin from slice 6 E9-E10: mass in slice 10 showing nearest approach to anterior margin E11: posterior margin slice 7 E12-E13: posterior inferior margin slice 8 E14: posterior margin slice 9 E15: anterior margin slice 9 E16: anterior margin slice 8 E17: anterior superior margin slice 6 E18-E20: sections immediately lateral to mass (slice 5) E21-E22: sections immediately medial to mass (slice 10) E23: grossly unremarkable breast parenchyma slice 3 E24: grossly unremarkable breast parenchyma slice 12 E25: lateral margin serially sectioned (slice 1) E26: medial margin serially sectioned (slice 14) F.Container F is further designated as '3. Additionalsuperior medial margin,. short stitch marks new true margin.' Received fresh is a 38.0 gram portion of. yellow, lobulated fibroadipose tissue that measures 8.5 x 6.0 x 1.5 cm. The. short stitch designates the new true margin. This aspect is inked blue. The. specimen does not have any further orientation. The specimen is serially sectioned to reveal that is primarily composed of yellow, lobulated adipose
+
+--- Page 8 ---
+tissue with a region of enhanced firm, white fibrosis measuring 2.4 x 1.5 x 1.5 cm that appears to abut the new true margin. The specimen is entirely submitted sequentially in cassettes F1-F23 with the fibrotic region in F9-F14. Pathologist Sign Out:
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diff --git a/output/text/6c5fbd37-d9c4-4045-bbc6-0d59c23b808e.txt b/output/text/6c5fbd37-d9c4-4045-bbc6-0d59c23b808e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..03220ca9f718683ffa14a65a922e8eb5b9ebe7c4
--- /dev/null
+++ b/output/text/6c5fbd37-d9c4-4045-bbc6-0d59c23b808e.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+pinted. Department of Pathology Page 1 of 4 REPORT Tel: UUID:21AF9D90-AD49-4757-B96A-F536F40408E7 TCGA-VD-A8KO-01A-PR Redacted Clinical Consultant & Location  Sex Unit No Thls Copy For:e TCD-t Malanonro, Rpundle cll 8774/3 SPECIMEN Lre 3 Right eye globe. Sib & Chersid cb93 CLINICAL DETAILSS V1117/14 Tumour size: 16.24 x 10.81 x 14.79mm History of blurred vision. Visual field defect. Pain since 6 months. MACROSCOPIC DESCRIPTION A fresh, intact right globe. Dimensions: Axial 25mm, Horizontal 24.5mm, Vertical 24mm Cornea: Horizontal 11.5mm, Vertical 11mm Optic nerve Length 12.5mm, Diameter 4mm Pupil: regular On trans-illumination, a shadow is seen in the supero medial measuring 19mun in maximum diameter. Plane of section: vertical oblique Intraocular description: On opening, a nodular, pale mass is seen, slightly anterior to the equator.. Tumour size LBD 9mm, Height 8.5mm MICROSCOPY Sections show a virtually non-pigmented choroidal melanoma extending from the ora serrata'/ pars plana up to the. equator. Tumour consists predominantly of spindle cells. The number of mitosis is approximately 4/40 high power fields. Closed loops are focaliy present in the planes of sections. The lymphocytic infiltrate within the tumour is minimal.. Tumour necrosis is not seen. There is no tumour extension Reported: Pathologist: Electronically Verified:
+
+--- Page 2 ---
+fet Department of Pathology. Page 2 of 4 HISTOPATHOLOGY REPORTE Tel: Surname Lab No Clinical Consultant & Locatlon  DOB/Age Forename(s) Sex Unit No Request Date This Copy For: through the sclera, optic nerve or vortex veins examined. Tumour cells are not seen at the resection margins. Elsewhere, the cornea shows no significant abnormality. The anterior chamber angles are open and the anterior chamber is shallow. The iris shows no significant abnormality. ciliary processes away from tumour show slight hyalinisation. Retina overlying the tumour is slightly atrophic and Bruch's. membrane appears intact. DIAGNOSIS Right eye, enucleation: Choroidal melanoma of predominantly spindle' cell type. COMMENT Immunohistochemistry will be carried out for completion. In addition, molecular genetic examination of Dna extracted from the tumour cells will be performed using. multiplex-ligation dependent probe amplification (MLpA). looking at chromosomes 1, 3, 6 and 8.~A supplementary report will follow in due course. SUPPLEMENTARY REPORT - Immunohistochemistry confirms that tumour cells express Melan-A and Hsp 27 (score 2). COMMENT SPECIMEN 2= Eye TUMOUR PRESENT Yes TUMOUR TYPE 1= Melanoma CELL TYPE 2= Spindle B CT LOOPS 2= Closed loops NECROSIS NO Reported: Pathologist: Electronlcally Verified:
+
+--- Page 3 ---
+printed: Department of Pathology Page 3 of 4 HISTOPATHOLOGY REPORT Tel: Surname Lab No Clinical Consultant & Locatlon Forename(s)  DOB/Age Sex Unlt No Request Date This Copy For: PIGMENTATION No LYMPHOCYTIC INFILTRATION No MITOTIC FREQUENCY 4/40 HPF DIFFUSE MELANOMA  No SPREAD 1= No CLEARANCE 2- Adequate HSP-27 POSITIVITY 2= 21-70% LARGE DIAMETER 9 mm THICKNESS 8.5 mm SUPPLEMENTARY REPORT In the meantime, molecular genetic analysis of tumour DNA extracted from the fresh uveal melanoma tissue was performed using multiplex ligation-dependent probe amplification (MLpA). These investigations were performed in the The kit p027 from which examines for gains or losses in 37 loci on chromosomes 1, 3, 6 and 8, was used. The DNA concentration was measured using  and the quality assessed using multiplex-pcR prior to the MLPA reaction. The DNA concentration was high and of good quality on assessment. The MLpA reaction was run at least twice on differing occasions, resulting in similar results. The results of the sequence analysis of the MLpA products is printed on a separate report. In summary, sequence analysis demonstrated: essentially normal chromosome lp, 3 borderline losses of chromosome 3 in the presence of 3 borderline gains, gains in chromosome 6p and normal chromosome 8. Reported: Pathologist: Electronically Verified: Case is (circle
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diff --git a/output/text/6c6b2893-e9b6-4d2b-a787-114ab64e19e3.txt b/output/text/6c6b2893-e9b6-4d2b-a787-114ab64e19e3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2211e152eea05e1b56a672d20d5676e5b4f834b0
--- /dev/null
+++ b/output/text/6c6b2893-e9b6-4d2b-a787-114ab64e19e3.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+IcD-t-3 FINAL PATHOLOGIC DIAGNOSISE A. Lymph node, right sentinel #1, excision:. Ouctal N6s' 85oof3 - One lymph node involved by metastatic carcinoma (1/1) Si+e: @ EreasHNoS c so9 B. Lymph node, right sentinel #2, excision: XS x|8[13 - One lymph node, negative for carcinoma (0/1) C. Lymph node, right sentinel #3, excision: UUID: 86806754-B000-4F8B-9037-95E7A0BD4020 TCGA-OL-A5RW-01A-PR Redacted - One lymph node, negative for carcinoma (0/1) D. Lymph node, right sentinel #4, excision: - One lymph node, negative for carcinoma (0/1) E. Breast, right, wire-localization lumpectomy: - Invasive ductal carcinoma, grade Ill/IIl, 2.0 cm in greatest dimension, surgical margins negative (see pathologic parameters and comment below) - Previous biopsy site Breast Pathologic Parameters 1. Invasive carcinoma: A. Gross measurement: 2.0 cm. B. Composite histologic (modified SBR) grade: II C. Associated intraductal carcinoma in situ (Dcis/LCiS): None 2. Excisional biopsy margins: Free of tumor. - Invasive carcinoma 6.0 mm from closest margin (posterior) 4. Blood vessel and lymphatic invasion: Present in breast parenchyma 5. Axillary lymph nodes: One of four sentinel lymph nodes involved by carcinoma (1/4)
+
+--- Page 2 ---
+- Size of largest metastatic deposit: 5.0 mm. - Extranodal extension: present (2.0 mm; largest focus). 6. Special studies (see - ER: No expression - PR: No expression - Her2/neu antigen (FisH): Non-amplified (ratio: 1.91) 7. pTNM (AJCC, 7th edition, 2010): pT1c, N1(sn), MX Clinical History: The patient is a year-old female with breast cancer undergoing lumpectomy.. Comment Immunohistochemical stains show the tumor cells to be positive for CK7 and negative for CK20 and TTF-1, consistent with the above diagnosis. D240 stain is. noncontributory. Specimens Received: A: Sentinel node #1
+
+--- Page 3 ---
+B: Sentinel node #2 C: Sentinel node #3 D: Sentinel node #4 E: Right breast partial; lumpectomy Gross Description: The specimens are received in five containers each labeled with the patient's name and medical record number. A. The first container is additionally identified as, 'sentinel node #1'. Received fresh and placed in formalin the specimen consists of a 4 x 3 x 1.2 lymph node. Specimen is serially sectioned and entirely submitted in cassettes A1-A8. B. The second container is additionally identified as, 'sentinel node #2'.. Received fresh and placed in formalin the specimen consists of a 1 x 1 x 0.5 cm Iymph node. Specimen is entirely submitted in cassette B1. C. The third container is additionally identified as, 'sentinel node #3'. Received fresh and placed in formalin the specimen consists of a 1 x 1 x 1 cm Iymph node. Specimen is bisected and entirely submitted in cassette C1.. D. The fourth container is additionally identified as, 'sentinel node #4'..
+
+--- Page 4 ---
+Received fresh and placed in formalin the specimen consists of a 2 x 1 x 1 cm lymph node. Specimen is serially sectioned and entirely submitted in cassette D1. E. The fifth container is additionally identified as, 'right breast partial. mastectomy'. Received fresh on a radiographic grid is a 96.5 gm lumpectomy specimen measuring 8.0 cm from medial to lateral, 8.5 cm from superior to inferior and 3.0 cm from anterior to posterior. The specimen is oriented with a short suture designating the superior pole and a long suture designating the. Iateral pole. There is a wire entering at the superomedial aspect of the specimen at grid C2. Accompanying the specimen is an x-ray demonstrating a. metallic clip located in grid position D3. The wire terminates in grid position D4. There is a circled mass in grid positions C3-D3, D4. The margins are inked as follows: anterior- black posterior - red superior - blue inferior - green medial - yellow lateral - violet The specimen is serially sectioned from lateral to medial into 8 slices. There is a 2.0 x 2.0 x 1.5 cm lesion located in slices 5 to 7. It is located 1.6 cm from the black margin, 0.6 cm from the red margin, 1.4 cm from the blue margin and 4.5 cm from the green margin. A metallic clip is identified in slice #5. The wire enters the specimen in slice #6 and terminates in slice #7. Tissue is banked from slices 4 and 6. Lumpectomy is entirely submitted. E1-E5: slice 1, medial margin E4-E10: slice 2 E11-E17: slice 3
+
+--- Page 5 ---
+E18-E28 : slice 4 E29-E41 : slice 5 (clip in E29-E31) E42-E52: slice 6 (mass in E42-E43) E53-E65: slice 7 E66-E83: slice 8 Tissue fixed for at least 6 hours in 10% NBF and no more than 72 hours.
\ No newline at end of file
diff --git a/output/text/6c7310a2-8825-4253-8619-0b01c24ef604.txt b/output/text/6c7310a2-8825-4253-8619-0b01c24ef604.txt
new file mode 100644
index 0000000000000000000000000000000000000000..de151a743a76763d93ca5d2d3938a26a704db32f
--- /dev/null
+++ b/output/text/6c7310a2-8825-4253-8619-0b01c24ef604.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:74597CF3-71A6-4F3A-91E5-F22FD31D44178 IcD 0-3 TCGA-3A-A9IC-01A-PR Redacted Coleuocouunsnia,oluetnos. 8560/3 Suti: Haneuss heag. C25.0 Pathology Report OtJ 4/r/14 Final Diagnosis A. BILE DUCT, PANCREAS, DUODENUM, WHIPPLE PROCEDURE: Invasive pancreatic ductal adenocarcinoma, moderately differentiated. See Key Pathological Findings. B. ADDITIONAL PANCREATIC MARGIN, EXCISION: Pancreatic intraepithelial neoplasia low grade.. There is no evidence of carcinoma and/or high grade dysplasia. :he attending pathologist, perscnally reviewed all slides and / or naterials and rendered the final Aiagnosis. Blectronically Signed Out by Key Pathological Findings. A: Pancreas-Exocrine Synoptic Datae SPECiMEN TYPE: Pancreatcoduodenectomy (Whipple resection), partial pancreatectomy TUMOR SITE: Pancreatic head TUMOR SIZE: Invasive: 4 x 3.5 x 2.5 cm *OTHER ORgANS rESeCTeD.:: *Duodenum Ductal adenocarcinonia HISTOLOGIC GRADE: G2: Moderately differentiated EXTENT OF INVASION -PRIMARY TUMOR: Tumor invades adjacent structures/organs Duodenum PRIMARY TUMOR (pT): pT3: Tumor extends beyond the pancreas but without involvement of the celiae axis or the superior mesenteric artery REGIONAL LYMPH NODES (pN) pN1b: Metastasis in multiple regional lymph nodes Number examined:  21 Number involved: 4 DISTANT mETASTASIS (pM): pMX: Cannot be assessed MARGINS: Margins free of tumor  Distance of invasive carcinoma from closest margin: 1 mm *Specify margin (if possible): retroperitoneal margin PANCREATIC RESECTION MARGIN, INVOLVED BY:: PanINIb *VENOUS (LARGE VESSEL) INVASION (V): *Absent *LYMPHATIC (SMALL VESSEL) INVASION (L): *Present
+
+--- Page 2 ---
+*PERINEURAL INVASION: *PresentE *ADDITIONAL PATHOLOGIC FINDINGS *Acute pancreatitis *Chronic pancreatitis Specimen(s) Received A BILE DUCT, PANCREAS, DUODENUM FS B ADDITIONAL PANCREATIC MARGIN FS Clinical History Not given.. Preoperative Diagnosis Pancreatic adenocarcinoma. Intraoperative Consultation. FSA BILE DUCT.PANCREAS,DUODENUM Common bile duct margin tree of invasive carcinoma, focal intraductal papllary mucinous neoplasia (IPMN) present (obscuring cavity artifact present) Intradepartmental Consultation: The case was also reviewed by. 4D,who concurs with the above interpretation. FSB ADDITIONAL PANCREATIC MARGIN: No evidence of malignancy. Comment: This frozen section diaanosis/result was communicated to and acknowledged by Dr. in frozen section room a1 MD and i MDhave performed the intraoperative consultations and Issued the above diagnosis. Gross Description The specimen is received fresh for frozen section analysis labeled *bile duct, pancreas, 4. duodenum. The specimen consists of a resected portion of the pancreatic head (4.5 x 4 x 3 cm) and attached duodenum (12 cm in length and 6 cm in greatest circumference). The serosal surface of the duodenum is brown-tan and smooth. Upon opening, the lumen contains a moderate amount of viscous bile. The mucosal surface of the duodenum exhibits normal folds with no gross evidence of polyps or nodularity. The pancreatic margin resection is marked with black ink, the portal vein groove i3 marked with blue.  ink and the retroperitoneal surface is marked with green ink. There is no stapied line grossly present. that would indicate the superior mesentery artery. A palpable pancreatic mass is identified. The pancreatic duct is not probe patent and is totally occluded by the presence of the tunor. Serial sectioning into the pancreas reveals a firm, yellow-gray, ill-defined mass 4 x 3.5 x 2.5 cm)which abuts the retroperitoneal surface/uncinate process. Grossly the mass does
+
+--- Page 3 ---
+appear to involve the common bite duct, which is probe patent and somewhat dilated with an inserted. catheter. Grossly the mass does appear to involve the duodenal wall extending to the mucosal surface and grassly involving the ampulla of Vater. There is a minimal amount of grossly uninvolved pancreatic tissue. A section of the minimal amount of attached adipose tissue isolates 2 moderately firm, round, tan, irregular lymph nodes, which measure 1.5 cm in greatest dimension. The lymph nodes are isolated adjacent to the pancreas. A representative frozen section is taken and submitted as FSA1. Permanent sections are submitted as: A2: Mirror image of tumor submitted to Tissue Bank. A3: Tangential pancreatic margin attached to specimen. A4: Perpendicular portal vein groove.. A5: Tangential proximal duodenal margin of resection. A6: Tangential distal duodenal margin of resection. A7-A8: Sections of tumor showing relationship ta retroperitoneal surface (green ink).  A9-A10:Tumor showing its relationship to common bile duct and ampulla of Vater. A11: Tumor showing its relationship to duodenum A12: Grossly unremarkable pancreas. A13: Grossly unremarkable duodenal mucosa. A14: One bisected lymph node. A15: One bisected lymph node.. A16-A18 Entire remaining adipose tissue. A representative section of the tumor is submitted to the Tissue Procurement Laboratory.  The specimen is received fresh for frozen section analysis labeled *additional pancreatic B. margin.* The specimen consists of a 3 x 1.5 x 0.5 cm, firm, gray-yellow, irregular fragment of tissue. The margin is entirely submitted tangentially for frozen section as FsB1. w1/2//y ase is (circle)
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diff --git a/output/text/6c849c0f-3207-4e24-8d14-ed2272be7427.txt b/output/text/6c849c0f-3207-4e24-8d14-ed2272be7427.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5f7996d399a38b334545fbb6277b156cc98a24b5
--- /dev/null
+++ b/output/text/6c849c0f-3207-4e24-8d14-ed2272be7427.txt
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+
+--- Page 1 ---
+Patient Results M Surgical Pathology Path Report Final] Final SURGICAL PATHOLOGY REPORT ACCESSION NO. : Final Diagnosis(es): Iedo-3 (A) Left kidney and adrenal gland, radical nephrectomy: 1)' Papillary renal cell carcinoma (5.5 cm), Type 2, ereindmo,capQery renal eeQI Fuhrman grade 3 of 4 (see Synoptic Report). 8Q60l3 2) Tumor focally invades renal sinus. 3) Separate tumor focus located in proximal ureter (0.7 cm). 4) Pathologic stage: pT3a N1 MX. C649 5) Adrenal gland with no pathologic abnormality. (B) Left adrenal gland, completion adrenalectomy: 1d/41!3 1)' Benign adrenal gland. 2) No malignancy identified. (C) Lymph nodes, para-aortic, excision: 1) Metastatic papillary renal cell carcinoma involving two of two lymph nodes (2/2). 2) Extracapsular extension identified.  UUID:B67F4143-2D87-4682-B17B-23C6D99D02B0 (D) Lymph nodes, para-aortic, excision: TCGA-A4-A7UZ-01A-PR Redacted 1) Metastatic papillary renal cell carcinoma involving ten of sixteen lymph nodes (10/16). 2) Extracapsular extension identified. 3) Vascular invasion present. (E) Lymph nodes, interaortocaval, excision: 1) Metastatic papillary renal cell carcinoma involving two of two lymph nodes (2/2). 2) Vascular invasion present. (F) Ureter, left distal, ureterectomy: Benign ureter, negative for malignancy. Synoptic Report: Laterality: Left. Specimen Procedure: Radical nephrectomy. Tumor Site: Middle. Tumor Size: 5.5 x 5.0 x 4.5 cm. Tumor Focality: Multifocal (kidney and ureter) Macroscopic Extent of Tumor: Limited to kidney. Histologic Type: Papillary renal cell carcinoma. Sarcomatoid Features: Not identified. Tumor Necrosis: Present, 5%. Histologic Grade (Fuhrman Nuclear Grade): Grade 3, Type 2. Microscopic Extent of Tumor: Renal sinus, focal. Lymphvascular Invasion: Present. Margins: Ureteric: Negative. Vascular: Negative. Soft Tissue: Negative. Regional lymph nodes: Printed from: Page: 1 of 6
+
+--- Page 2 ---
+Patient Results m Number examined: 20 Number positive: 14 Pathoiogic Staging: pT3a N1 MX. Pathologic Findings in Non-Neoplastic Kidney: Mild, patchy, interstitial, chronic inflammation. Immunohistochemistry: RCC: Positive PAX-8: Positive CD10: Positive CK5: Negative p63: Negative Comments: The morphologic features and immunohistochemical profile supports the diagnosis of papillary renal cell carcinoma. Although spread into the ureter is unusual for renal cell carcinoma, the main kidney mass and tumor within the ureter share the same immunohistochemical profile and morphologic appearance, representing the same tumor.. This case has been reviewed and the diagnosis agreed upon by sultina departmental surgical pathology staff.. The gross description and all microscopic slides have been reviewed and interpreted by the undersigned pathologist' Electronically Signea Specimen(s) Keceiveu. A: Left kidney and adrenal gland B: Left adrenal gland C: Para-aortic lymph nodes D: Para-aortic lymph nodes E: Part of interaorta caval F: Distal ureter, left Clinical History: Left kidney cancer. Intraoperative Consultation: Time Received: Time Reported: FSA1-FSA2: Left kidney mass: Carcinoma, favor urothelial (2 blocks). FSC1-Fsc2: Paraaortic lymph node: Metastatic carcinoma, favor papillary renal cell carcinoma (2 blocks).. Gross Description: (A) (left kidney and adrenal gland) Specimen components and dimensions: Received fresh for frozen section analysis is a kidney and perinephric fat measuring 29.0 Printed from: Page: 2 of 6
+
+--- Page 3 ---
+Patient Results m x 23.0 x 6.0 cm. The specimen weighs 1,270 gm. The kidney itself measures 12.0 x 6.5 x 5.0 cm. The attached adrenal gland measures 4.5 x 1.5 x 1.0 cm. The attached ureter measures 5.5 cm in length and has an average diameter of 0.4 cm. The kidney has been shelled out of the perinephric fat and bivalved by the surgeon. The perinephric fat is inked black. The capsular surface of the kidney is tan-brown. There are multiple small white granular lesions ranging in size from 0.1 to 0.5 cm on the surface. A portion of the tumor appears to be pushing the capsule out and this area measures 4.5 x 3.0 x 2.6 cm. It does not appear to be grossly invading through the capsule. Size, appearance and location of tumor: Bivalving the specimen reveals a tan-white to pink friable mass (5.5 x 5.0 x 4.5 cm) present within the center of the kidney. There is an additional small tan-pink nodule (0.7 x 0.5 x 0.4 cm) at the proximal ureter. A representative section of the smaller mass is submitted in FSA1. A representative section of the large tumor is submitted in FSA2..  Renal capsule/Renal sinus: The tumor appears to be extending the capsule, but does not appear to grossly invade through the capsule into the perinephric fat. The tumor appears to abut the renal sinus; however, no gross invasion is identified. The small mass on the ureter does not appear to grossly invade into the ureter. Renal vein: Not clearly identified. Other findings: None.. Uninvolved tissues: The adrenal gland appears golden yellow with small punctate hemorrhage areas present. The uninvolved  renal parenchyma appears tan-brown. The medulla is tan-pink. The average cortical thickness is 0.9 cm. The uninvolved ureter serosa is tan-pink, smooth and glistening. The uninvolved ureter mucosa is tan-white and striated. Lymph nodes: Five potential lymph nodes are identified in the hilum fat ranging in size from 0.4 to 1.1 cm. The larger nodes are firm and suspicious for tumor involvement. Blocks submitted: FSA1-FSA2 - representative tumor (large mass and smaller ureteral mass, respectively) A3 - representative shave margin of all vascular structures identified. A4 - entire small lesion found on the ureter and cross sections A5-A6 - representative sections of the tumor and its relationship to the sinus fat A7 - representative section of the tumor and its relationship to the renal pelvis and sinus fat A8 - representative section of the tumor and its relationship to the uninvolved renal parenchyma A9-A10 - representative section of the tumor and in its relationship to the capsule where it protrudes A11 - representative section of perinephric fat Printed from: Page: 3 of 6
+
+--- Page 4 ---
+Patient Results m A12 - representative section of grossly uninvolved renal  parenchyma and uninvolved ureter A13 - five potential lymph nodes intact A14 - adrenal gland (B) (left adrenal giand) Received in formalin is a portion of adrenal gland measuring 5.5 x 3.5 x 3.5 cm. The adrenal gland is golden yellow with red hemorrhagic tissue within the center. Serial sectioning of the adrenal gland demonstrates no grossly identified masses. Representative sections are submitted in cassettes B1-B3. (C) (para-aortic lymph nodes) Received fresh for frozen section is tan-red tissue measuring 5.0x 2.5 x 2.0 cm. Three firm lymph nodes are identified ranging in size from 1.2 to 4.0 cm. the smallest lymph node is inked black and submitted intact along with one representative section of the middle-sized lymph node in FSC1. A representative section of the largest lymph node is submitted in FsC2. The remainder of the middle-sized Iymph node is serially sectioned and submitted entirely in cassette C3. The largest lymph node is serially sectioned and submitted in cassettes C4-C6. (D) (para-aortic lymph nodes) Received in formalin are two fragments of tan-red fibroadipose tissue measuring 7.0 x 10.5 x 4.0 cm. There are multiple surgical clips and sutures present. Additionally present are fragments of a vascular structure. Sixteen potential lymph nodes are identified which are firm and rang in size from 0.4 to 6.0 cm. Biocks are submitted as follows: D1 - representative sections of the vascular structures identified within the specimen. D2 - six potential lymph nodes intact D3 - three potential lymph nodes intact D4 - one matted lymph node bisected  D5 - one potential lymph node bisected D6-D8 - one lymph node serially sectioned D9-D10 - one lymph node serially sectioned D11-D14 - one lymph node serially sectioned D15-D16 - representative sections of one lymph node D17-D19 - representative sections of the largest lymph node (E) (part of interaortocaval) Received in formalin is one fragment of tan-pink fibroadipose tissue measuring 5.5 x 5.5 x 3.0 cm. Two large firm matted lymph nodes are identified ranging in size from 3.0 x 5.5 cm. Blocks are submitted as follows: E1-E2 - representative sections from the smaller matted lymph node E3-E5 - representative sections of the larger matted lymph node (F) (distal ureter, left) Received in formalin is a portion of ureter measuring 5.0 cm in length and having a diameter ranging from 0.6 to 0.5 cm. There is a stapled and suture on one end of the ureter. This end of the ureter is inked blue. The ureter Printed from: Page: 4 of 6
+
+--- Page 5 ---
+Patient Results m is seriaily sectioned. Blocks are submitted as follows: F1 - the inked blue margin which was the one with a staple and suture on it as well as the opposite margin F2 - the remainder of the specimen serially sectioned Microscopic Description: Complete microscopic evaluation has been performed. Appropriately reacting controls have been performed and evaluated for all stains on this case as required. Histopathology has a list of iH antibodies that are regulated as analyte specific reagents (ASR's). These assays were developed and their performance characteristics determined by the They have not been cleared by the US Food and Drug Aaministration. The FDA has determined that such clearance or approval is not necessary for the ASR's. These tests are not investigational and are used in standard clinical care. In cases where Immunohistochemistry testing is performed, the following antibodies and their respective clones may be used to determine therapy for the patient: EFGR(3c6), ER(SP1), PR(1E2), Her2neu(4B5), CD117(Poly). CD20(L26) Ki67(30-9). Uniess otherwise stated in the report, all tissue tested for ERPR by IHC, Her2 by IHC and/or HER2 by FiSH have been tixed as per C.A.P. requirements for a minimum of 6 hours and a maximum of 48 hours. ER, PR, Ki-67, p53 are reported as a semi-quantitative percentage of positively stained nuclei. Her-2/neu and EGFR are scored as follows: No staining at all is scored as (0), weak, incomplete membrane staining in any proportion of cells is scored as (1+), less than strong but complete staining in any proportion of cels or complete strong staining in less than 30% of cells is scored as (2+), and strong complete staining in more that 30% of cells is scored as (3+). All studies are performed on tissue fixed in 10% neutral buffered formalin and embedded in paraffin unless otherwise stated in the report. Printed from: Page: 5 of 6
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diff --git a/output/text/6c851f95-564c-4a79-94c2-ffa75e74611c.txt b/output/text/6c851f95-564c-4a79-94c2-ffa75e74611c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3822489e6317d99a137f5037e1a6f94f9bc6ae46
--- /dev/null
+++ b/output/text/6c851f95-564c-4a79-94c2-ffa75e74611c.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: FMP/SSN: DOb/Age/Sex: Specimen #: Location: F RaCe: ASIAN - PACIFIC ISLANDERTaken: Physician(s) : Received: Reported: SPECIMEN: A: SENTINEL LYMPH NODE #1 LEFT 1cs-0-3 B: NON SENTINEL LYMPH NODE LEFT Carcnoma,mifiltrstng cluctrl, nos 950v13 C: LEFT BREAST AND AXILLARY CONTENT Srte: brast NoS C50.9 FINAL DIAGNOSIS: 1f25/1 lw A-C. BREAST, LEFT, MASTECTOMY WITH AXILLARY AND SENTINEL LYMPH NODES: TUMOR TYPE: INVASIVE DUCTAL.CARCINOMA WITH AN EXTENSIVE INTRADUCTAL COMPONENT (70-8o% intraductal tumor largely intermixed with invasive) NOTTINGHAM GRADE: GRADE II (MODERATELY DIFFERENTIATED) NOTTINGHAM SCORE: 6 (Tubules= 2, Nuclei= 3, Mitoses- 1; mitotic count <l per 10 HpF) TUMOR SIZE (GREATEST DIMENSION): 4.1 CM (MEASURED GROSSLY). TUMOR NECROSIS: NOT IDENTIFIED. MICROCALCIFICATIONS: PRESENT IN INVASIVE AND IN SITU TUMOR AND IN BENIGN DUCTS VENOUS / LYMPHATIC INVASION: PRESENT MARGINS: NEGATIVE NEAREST MARGIN, INVASIVE TUMOR: 2.5 MM (DEEP, SLIDE C6) NEAREST MARGIN, IN-SITU TUMOR: 3 MM (DEEP, SLIDE C6) INTRADUCTAL COMPONENT: DUCTAL CARCINOMA IN SITU, CRIBRIFORM TYPE NUCLEAR GRADE: 3 LYMPH NODES: METASTASIS IN TWO OF EIGHTEEN (2/18) EXAMINED LYMPH NODES ONE (1) SENTINEL LYMPH NODE (SPECIMEN A): POSITIVE EXTRANODAL EXTENSION: PRESENT, 4 MM ONE (1) LYMPH NODE (SPECIMEN C, LOW, C12): POSITIVE EXTRANODAL EXTENSION: PRESENT, 1 MM NIPPLE INVOLVEMENT: NOT IDENTIFIED. SKIN INVOLVEMENT: NOT IDENTIFIED. MULTICENTRICITY: NOT PRESENT. ESTROGEN, PROGESTERONE RECEPTOR STATUS AND HER 2 NEU WERE REPORTED PREVIOUSLY IN SURGICAL CASE PATHOLOGIC STAGE: pT2N1aMX ADDITIONAL PATHOLOGIC CHANGES: COLUMNAR CELL CHANGE WITH ATYPIA SCLEROSING ADENOSIS FIBROCYSTIC CHANGES, USUAL DUCTAL HYPERPLASIA, FIBROADENOMA MENT : UUID:F80009EE-0A5C-4CAB-9EB3-4886431A9A84 TCGA-A2-A0CV-01A-PR Redacted Continued on Next Page - PRIVACY ACT OF 1974
+
+--- Page 2 ---
+FOR OFFICIAL USR ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: FINAL DIAGNOSIS (continued): Specimen #: The earlier report, are positive (ioo% strong staining for both estrogen and progesterone , of a core biopsy indicates hormone receptors receptors) and Her2 by immunihistochemistry is NEgATivE (1+). ** Report Electronically Signed Out ** CLINICAL DIAGNOSIS AND HISTORY: year old with left breast 4 X 4 cm mass in left upper outer quadrant detected with lcm lymph node PRE-OPERATIVE DIAGNOSIS: left breast cancer POST-OPERATIVE DIAGNOSIS: same FROZEN SECTION DIAGNOSIS: SPECIMEN TYPE:LYMPH NODE TIME RECEIVED: TIME REPORTED:: REPORTED TO: DR. REPORTED BY: DR. # BLOCKS: 2 # SCRAPE PREPS:2 FROZEN SECTION DIAGNOSIS: POSITIVE FOR METASTATIC CARCINOMA. GROSS DESCRIPTION: A. Received fresh for intraoperative consultation labeled with patient's name designated "SENTINEL NODE #1 COUNT 104" consists of a 1.0 x 0.8 x 0.5 cm very firm lymph node with homogeneous yellow tan cut surface. Touch preps are prepared. Half of node submitted for cBcp protocol and remaining half submitted for paraffin section. B. Received fresh labeled with the patient's name "NON-SENTINEL LYMPH NODE LEFT" is tan pink soft tissue measuring 0.7 x 0.5 x 0.2 cm. The presumed lymph node is bisected and submitted entirely. designated Received fresh labeled with patient's name designated "BReAST Page 2 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 Continued on Next Page
+
+--- Page 3 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATAS SURGICAL PATHOLOGY REPORT Patient: GROSS DESCRIPTION (continued) : Specimen #: AND AxILLARy cONTENTs" consists of 380 gram left mastectomy oriented with. single stitch medial, two stitches superior, stitch on highest axillary portion. Specimen measures 23 cm medial to lateral 15 cm superior to. inferior, 3 cm anterior to posterior. Attached skin ellipse displays a centrally located everted nipple measuring 1 cm. No discharge is. identified. No scars are identified.. There is a well-defined pink white firm gritty mass in the left outer. quadrant measuring 4.1 x 3.5 x 1.5 cm. Tissue surrounding the mass is. remarkably nodular and firm with possible superior extension of primary lesion to approximately 5 cm (c4). Focal hemorrhage consistent with previous biopsy is also noted. Remaining quadrants are also composed of remarkably nodular focally indurated dense fibrous tissue. No additional masses identified. Fatty tissue comprises 20% of specimen and is unremarkable. The attached axillary tail measures 9 x 3.5 x 1.5 cm. Sectioning reveals sixteen lymph nodes ranging from 0.5 x 0.7 cm in greatest dimension.. Sectioning of lowest lymph node shows a firm pink white cut surface with possible involvement by lesion. INK KEY: blue:  superficial black: deep SUMMARY OF SECTIONS: c1: skin c2: lower outer quadrant mass. c3: margin of C2 C4: possible extension of tumor C5: margin of C4 C6: mass with deep margin c7: additional mass c8: lower outer quadrant c9: upper outer quadrant c10: upper inner quadrant c1l: lower inner quadrant c12: one low lymph node c13: two low bisected lymph nodes, one inked blue. c14: three low lymph nodes. c15: one high lymph node c16: two high lymph nodes bisected, one blue. c17: one high lymph node intact. Matched sections of c1 c7-c12 and c15 are submitted in Ocr for cBcp rotocol. Page 3 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 Continued on Next Page
+
+--- Page 4 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: GROSS DESCRIPTION (continued) : Specimen #: c18: nipple c19: mass with deep margin c20: mass with deep and~superficial margin c21: six additional lymph nodes. 21cF Page 4 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 End of Report
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diff --git a/output/text/6c8aaba6-464d-4014-b318-ef55b2f356d7.txt b/output/text/6c8aaba6-464d-4014-b318-ef55b2f356d7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7fae700a71f80ca4a977752c054423c1972126ba
--- /dev/null
+++ b/output/text/6c8aaba6-464d-4014-b318-ef55b2f356d7.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+DIAGNOSIS: 1) TONGUE, RIGHT BASE, BIOPSY: POORLY-DIFFERENTIATED SQUAMOUS CELLCARCINOMA (SEE COMMENT). COMMENT: Immunohistochemical studies show strong marking with p16, and HPVis negative. CLINICAL DATA Clinical Features:Unspecified Operative Findings: Unspecified Operative Diagnosis: Unspecified Tissue Submitted: 1) right base of tongue INSTRUCTIONS: High-risk HPV ISH P16 IHC. GROSS DESCRIPTION: 1) SOURCE: Right Base of Tongue. Received fresh labeled "right base of tongue," is one larger fragment and multiple minute fragments of pink-tan to red tissue measuring in aggregate 8.0 x 6.0 x 4.0 mm. The largest portion of tissue has a white, thickened,polypoid surface. The section margin of this larger portion is inked black. The specimen is submitted entirely. Tissue is submitted for future possible study. Summary of sections: 1A, larger portion, 2/1; 1B, fragments in a tissuebag, M/1. The following special studies were performed on this case and theinterpretation is incorporated in the diagnostic report
+
+--- Page 2 ---
+above: 1xP16. 1xPAPILLOMA VIRUS In some tests, analyte specific reagents (ASRs) are used. In the case of an ASR, this test was developed and its performance characteristicsdetermined by this laboratory. It has not been cleared or approved by theUS Food and Drug Administration. The FDA has determined that suchclearance or approval is not necessary. This test is used for clinical purposes. It should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of as qualified to perform high complexity clinical laboratory testing. The following report contains additional information regarding HPV studies that supplements the previously issued report. ADDENDUM FINDINGS:HPV analyses as performed by Laboratories show the tumor to be p16 positive byimmunohistochemistry and HPV-16 positive by in situ Slides and report reviewed by Attending Pathologist.
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diff --git a/output/text/6cbe19af-a079-4ca6-afe6-26ea690c40f2.txt b/output/text/6cbe19af-a079-4ca6-afe6-26ea690c40f2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..091049053ed78afa9229d52e2f7320034d4a2b16
--- /dev/null
+++ b/output/text/6cbe19af-a079-4ca6-afe6-26ea690c40f2.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Reda cte ICD-03 areincmo, ukittalug duct 8500/3 Age: Sex: Female Tissue Source Site (TSS): uJ 5/1q|14 Date of Tumour Procurement: 1.  GROSS ASSESSMENT: Cut section showed a variegated tumour 2.MICROSCOPIC ASSESSMENT Microscopic description: Section shows an invasive tumour growing solid nests, cords, comedo and tubular patterns.. It is composed of large cells having moderately pleomorphic hyperchromatic nuclei and amphophilic cytoplasm. The stroma is. demoplastic containing similar tumour cells and lymphocytes. Focal areas of necrosis noted. 3.Tumour Type: Malignant 4. Tumour Site: Left Breast 5. Distance of invasive carcinoma to closest margin: 5mm Which margin? Deep resection
+
+--- Page 2 ---
+TSS Unique patient ID: 6.HISTOLOGICAL DIAGNOSIS: Invasive ductal carcinoma 7. COMMENTS: Dr Signature Date Reporting Pathologist Name lW 43 a
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diff --git a/output/text/6d2384ae-41b2-4f4e-b2ba-94d612da6fc4.txt b/output/text/6d2384ae-41b2-4f4e-b2ba-94d612da6fc4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..da27c67daff500f390c3cc406d9ad04169b3de1b
--- /dev/null
+++ b/output/text/6d2384ae-41b2-4f4e-b2ba-94d612da6fc4.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Other Related Data: Billing Type: Financial Number Clinical Diagnosis & History: with bilateral multifocal enhancing renal masses. and liver mass. Specimens Submitted: 1: SP: Segment four of liver nodule 2: SP: Left kidney and adrenal DIAGNOSIS: 1) LIVER, SEGMENT 4, NODULE; SEGMENTECTOMY: - HYPERPLASIA OF LIVER PARECHIMA WITH A VAGUE NODULARS PATTERN IN THIS SAMPLE. MILD STEATOSIS. 2) KIDNEY AND ADRENAL GLAND, LEFT; RADICAL NEPHRECTOMY: - RENAL CELL CARCINOMA, CLEAR CELL TYPE, NUCLEAR GRADE II/IV. THE PATTERN OF GROWTH IS ACINAR. THE TUMOR GREATEST DIAMETER IS 13.5 CM. THE TUMOR EXTENDS THROUGH THE RENAL CAPSULE AND INTO THE HILUM OF THE KIDNEY, BUT IS CONFINED WITHIN GEROTA'S FASCIA. NO INVASION OF THE RENAL VEIN IS IDENTIFIED. ALL SURGICAL MARGINS ARE FREE OF TUMOR. THE NON-NEOPLASTIC KIDNEY IS UNREMARKABLE. THE ADRENAL GLAND IS UNREMARKABLE. Gross Description: The specimen is received fresh for frozen section, labeled "Segment 4 of Liver Nodule". It consists of a 1 x 0.9 x 0.8 cm, brown-tan, soft tissue. Entirely frozen. Page 1 of 2
+
+--- Page 2 ---
+Summary of Sections: FSC  - frozen section control 2) The specimen is received fresh, labeled, "Left Kidney and Adrenal". It consists of a kidney, adrenal gland, an 8.2 cm long segment of ureter. The specimen measures 21.0 x 12.0 x 9.5 cm and weighs 950 grams. Bivalving reveals a large ill-defined tumor arising in the upper pole and measuring 13.5 x 8.0 x 7.8 cm with one satellite nodule situated 0.6 cm from the main mass, measuring 1.2 cm in greatest dimension. The tumor is rimmed by golden, yellow-tan tissue with extensively hemorrhagic and centrally fibrotic. Adrenal gland does not appear to be grossly involved. Sectioning of the perinephric fat does not reveal gross extension of tumor through the renal capsule. The tumor extends to the upper peripheral portion of renal pelvis and renal vein does not appear to be grossly involved. Representative sections of tumor with surgical margin is submitted. Summary of Sections: VM - vessel margin UM - ureteral margin K - kidney SN - satellite nodule RP - renal pelvis P - pelvis. A - adrenal. T - tumor Summary of Sections: Part Sect. SiteBlocks Pieces All 1 FSC 1 1 Y 2 A 1 1 K 1 1 P 1 1 RP 1 14 SN 1 1 T 9 M UM 1 M VM 1 M Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS: BENIGN HEPATOCELLULAR LESION. (RG) PERMANENT DIAGNOSIS: SAME. Page 2 of 2 END OF REPORT
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diff --git a/output/text/6d28bebe-cb61-42aa-a455-96e887c7a90d.txt b/output/text/6d28bebe-cb61-42aa-a455-96e887c7a90d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3b1bff8a1bf97907238731adf8b4a541fb20be5f
--- /dev/null
+++ b/output/text/6d28bebe-cb61-42aa-a455-96e887c7a90d.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Metstatic kyrph Nnde UUID:72FE0659-6B7E-4129-B61D-C376C59C428F TCGA-E2-A15K-06A-PR Redacted TSS: SPECIMENS: 1CL- O-3 A. RIGHT BREAST LUMPECTOMYE B. RIGHT AXILLARY CONTENTS LEVELS 1,2 C. ADDITIONAL RIGHT AXILLARY TISSUE 8500/3 SPECIMEN(S): A. RIGHT BREAST LUMPECTOMY  B. RIGHT AXILLARY CONTENTS LEVELS 1,2 Site: lynph cnot axil/ary C. ADDITIONAL RIGHT AXILLARY TISSUE c77.3 GROSS DESCRIPTION: A. RIGHT BREAST LUMPECTOMY Received fresh labeled with the patient's identification and "right breast lumpectomy" is a previously inked, oriented /5 97g, 8 x 6.5 x 4.5cm lumpectomy. Ink code: anterior-yellow, posterior-black, superior-blue, inferior-orange, medial- green, lateral-red. Specimen is serially sectioned from lateral to medial into 8 slices revealing a 2 x 1.8 x 1.6cm tan white stellate mass, 0.6cm from the closest inferior margin in slices 2-5cm. A portion of the specimen is submitted for tissue procurement. Representatively submitted:. A1: lateral margin slice 1. A2-A4: slice 2 with mass in A4 A5-A7: slice 3 with mass in A6 A8-A11: slice 4 A12-A15: slice 5 with mass in A15 A16-A17: slice 6 A18-A19: slice 7 A20: medial margin slice 8 B. RIGHT AXILLARY CONTENTS LEVELS 1,2 Received fresh is a tan pink soft tissue fragment 15 x 12 x 4cm. Dissection reveals 14 lymph nodes ranging from 0.3 x 0.3 x 0.2cm to 5 x 3.2 x 1.5cm. The largest lymph node is sectioned to reveal a firm homogenous white cut surface. B1: 5 lymph nodes B2: 4 lymph nodes B3: 2 lymph nodes B4: 1 lymph node B5: 1 lymph node B6: 1 lymph node B7: 1 lymph node B8: 1 lymph node B9-B10: 1 lymph node  B11-B12: 1 lymph node B13-B16: representative sections of 1 lymph node C. ADDITIONAL RIGHT AXILLARY TISSUE  Received fresh is a tan pink soft tissue fragment 4.3 x 2.7 x 2cm. Dissection reveals a possible necrotic lymph node 2.8 x 1.3 x 1cm. Representatively submitted in C1-C4. DIAGNOSIS: A. BREAST, RIGHT, WIDE LOCAL EXCISION: - INVASIVE DUCTAL CARCINOMA, SBR GRADE 3, MEASURING 2.4-CM - INTERMEDIATE NUCLEAR GRADE, DUCTAL CARCINOMA IN SITU, SOLID TYPE - INVASIVE TUMOR INVOLVES INFERIOR SURGICAL RESECTION MARGIN AND PRESENT WITHIN 1 MM FROM MEDIAL SURGICAL RESECTION MARGIN - BIOPSY SITE CHANGES WITH FIBROSIS - SEE SYNOPTIC REPORT. B. LYMPH NODES, RIGHT, AXILLARY DISSECTION: - METASTATIC CARCINOMA TO TWO OF SEVENTEEN LYMPH NODES (2/17), LARGEST MEASURING 2.5-CM, WITH EXTRANODAL EXTENSION C. SOFT TISSUE, ADDITIONAL WHITE AXILLARY, EXCISION: - FIBROADIPOSE TISSUE WITH FAT NECROSIS, NO TUMOR SEEN. SYNOPTIC REPORT - BREAST Specimen Type: Excision
+
+--- Page 2 ---
+Needle Localization:  No Laterality: Right Invasive Tumor: Present Multifocality: No WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Tumor size: 2.4cm Margins: Involved at inferior Extent:: focal Tubular Score: 3 Nuclear Grade: 2 Mitotic Score: 3 Modified Scarff Bloom Richardson Grade: Necrosis: Absent Vascular/Lymphatic Invasion: Present Extent: focal Lobular neoplasia: None Lymph nodes: Axillary dissection Lymph node status:  Positive 2 / 17 Extranodal extension Micrometastases: No DCIS present  Margins uninvolved by DCIS DCIS Quantity:Estimate 2% DCIS Type: Solid  DcIs Location:Associated with invasive tumor Nuclear grade: Intermediate Necrosis: Absent ER/PR/HER2 Results ER: Positive PR: Positive HER2: Pending by FISH Pathological staging (pTN): pT 2 N 1a  Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimen: Surgical Excision Block Number: A4 ER: Positive Allred Score: 8 = Proportion Score 5 + Intensity Score 3 PR: Positive Allred Score: 4 = Proportion Score 2 + Intensity Score 2 COMMENT: The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate.  intensity of staining, 3 = strong intensity of staining), with a scoring range from 0 to 8.  ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2. METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Immunohistochemistry was performed using the mouse anti-human ER (ER 1D5, 1:100) and PR (PGR 136, 1:100)  provided by following the manufacturer s instructions. This assay was not modified. Interpretation of the ER/PR immunohistochemical stain is guided by published results in the medical literature,.  information provided by the reagent manufacturer and by internal review of staining performance.. SYNOPTIC REPORT - BREAST HER-2 RESULTS Specimen: Surgical Excision Block Number: A4 Interpretation: EQUIVOCAL Intensity: 2+ % Tumor Staining: 10% Fish Ordered: Yes , on Date
+
+--- Page 3 ---
+METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Her2 analysis was performed using the FDA approved. using rabbit anti- human HER2. This assay was not modified. External kit-slides provided by the manufacturer (cell lines with high, low and negative HER2 protein expression) and in-house known HER2 amplified control tissue were evaluated along. with the test tissue. Adequate, well preserved, clear-cut invasive carcinoma was identified for HER2 evaluation.  Interpretation of the HER2 immunohistochemical stain is guided by published results in the medical literature,. information provided by the reagent manufacturer and by internal review of staining performance. This assay has been validated according to the 2007 joint recommendations and guidelines from ASCO and CAP  and from the NCCN HER2 testing in Breast Cancer Task Force. The Pathology Department takes full responsibility for this test's performance. CLINICAL HISTORY: None provided. PRE-OPERATIVE DIAGNOSIS:E Right breast cancer. INTRAOPERATIVE CONSULTATION DIAGNOSIS: A: Right breast, lumpectomy: Mass is 0.6 cm from the closest inferior margin. By Dr., called to Dr. at. ADDENDUM: Results of the gross examination performed on specimen A were omitted from the original report and are as follows: HER-2 DNA Probe Kit Case No Analytical Interpretation of Results: HER-2 NOT AMPLIFIED Clinical Interpretation of results Amplification of the HER-2 gene was evaluated with interphase fluorescence in-situ hybridization (FiSH) on formalin-fixed paraffin embedded tissue sections using a chromosome. 17 centromeric probe and a HER-2 probe that spans the entire HER-2 gene in the  by Dr. A majority of tumors cells displayed 2 chromosome 17 signals and 2 HER-2 signals, with a HER-2/CEP 17 Ratio </=2.0, consistent with no amplification of the HER2/neu gene. Block used A4 Source of case: Tissue fixation formalin-fixed tissueOutside Case No:NA Tissue source breast  Results interpreted: yes HER2/CEP17 ratio: 0.9 This ratio is derived by dividing the total number of  HER-2/neu signals by the total number of CEP17 signals in at least 20 interphase nuclei with nonoverlapping nuclei in the neoplastic. mammary epithelial cells. Cells with no signals or with signals of only one color are disregarded. Method of ratio enumeration: manual count Limitations The  is not intended for use to screen for or diagnose breast cancer. It is  intended to be used as an adjunct to other prognostic factors currently used to predict disease-free.  and overall survival in stage il, node-positive breast cancer patients. In making decisions regarding  adjuvant CAF treatment, all other available clinical information should also be taken into. consideration, such as tumor size, number of involved lymph nodes, and steroid receptor status. No treatment decision for stage II, node-positive breast cancer patients should be based on HER-2/neu. gene amplification status alone.. Overview of this test FDA APPROVED REAGENT  HER-2 DNA Probe Kit is FDA approved for selection of  patients for whom Herceptin therapy is being considered. These tests were performed in the  under the direction of Dr. The results of these studies should always be interpreted in the context of the  clinical, morphological, and immunophenotypic diagnosis. Gross Dictation: Microscopic/Diagnostic Dictation: Pathologist, Final Review: Pathologist, Final: Pathologist, Addendum Review: Pathologist, Addendum Final: Pathologist, ' Addendum: Pathologist, Addendum Final: Pathologist, MetistHc Axillay Lynph NoL. hv 3/5/!y Criteria Prior Malignancy  History TC
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diff --git a/output/text/6d3cc428-7236-4317-8a44-b95ae71fc163.txt b/output/text/6d3cc428-7236-4317-8a44-b95ae71fc163.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5d6420022e1a66de5853d956468d60ac24cbae7b
--- /dev/null
+++ b/output/text/6d3cc428-7236-4317-8a44-b95ae71fc163.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+Page I of 4 UUID:DB6AF92C-6929-41F6-A40F-4CA1C40F2A30 TcGA-IB-AssT-0ia-pr Redacted Note: If you do not see "END OF PRINTED REPORT" at the bottom of tht the report YOU DO NOT HAVE THE ENTIRE REPORT. Please try print. CONFIDENTIAL SURGICAL PATHOLOGY REPORT Time Collected Time Reported Order Number Status Final Relevant Ic D-o-3 Information Location Aelerseaensrno, duet NoS 860013 Copied To Copy to Request, Insufficient Data for Site:Aeady pwreugos Report Patient  Name cQ5.0 Demographics (for verification Date of Birtn: wJ 4/2|13 purposes) Sex: F SURGICAL PATHOLOGY REPORT ****+Surgical Pathology Report**** Accession Number Collected Date/Time Received Date/Time Pathologist Specimen Description A. Gallbladder at B. 8A node at C. Whipple specimen at. Clinical Information Pancreatic mass Infectious patient:No Immunocompromised: No History of neoplasm: No. Diagnosis A. Gallbladder, Cholecystectomy:. Mild acute and chronic cholecystitis. Negative for dysplasia or malignancy. Cystic duct lymph node negative for malignancy.. B "8A Lymph Node": Mineral oil lipogranulomatosis.. Negative for malignancy. C. Head of Pancreas, Whipple's Resection: Invasive well to moderate differentiated pancreatic duct.
+
+--- Page 2 ---
+Page 2 of 4 adenocarcinoma. Margins clear. Metastatic carcinoma involving two of sixteen peripancreatic lymph nodes. Electronically signed by: Synoptic Report C: Pancreas (Exocrine). Macroscopic. SPECIMEN: Head of pancreas Duodenum Common bile duct Gallbladder PROCEDURE: Pancreaticoduodenectomy (Whipple resection), partial pancreatectomy TUMOR SITE: Pancreatic head TUMOR SIZE: Greatest dimension: 3.2 Additional dimensions: 2.5 x 2.0 cm C: Pancreas (Exocrine), Microscopic. HISTOLOGIC TYPE: Ductal adenocarcinoma HISTOLOGIC GRADE: G2:  Moderately differentiated MICROSCOPIC TUMOR EXTENSION: Tumor invades duodenal wall Tumor invades peripancreatic soft tissues MARGINS: Margins uninvolved by invasive carcinoma. Distance of invasive carcinoma from closest margin: 2 Specified margin:  Uncinate margin TREATmEnr EFFEcr (applicable to carcinomas treated with neoadjuvant therapy): Not known LYMPH-VASCULAR INVASION: Not identified PERINEURAL INVASION: Present PRIMARY TUMOR (pT) : pT3: Tumor extends beyond the pancreas but without involvement of the celiac axis or the. superior mesenteric artery REGIONAL LYMPH NODES (pN): pN1:  Regional lymph node metastasis. Number examined: Number involved: 16 DISTANT METASTASIS (pM): Not applicable Gross Description Received are specimen containers A to c. All reauisitions and specimen containers are. The cassettes and AP labelled with the patient's name, identifiers are labelled with the surgicds sumber. The A. The specimen is received fresh and is subsequently placed into formalin. container is designated " Gallbladder" and consists of an unopened gallbladder, measuring. 11.0 cm in length x 5.0 x 3.5 cm. The outer peritoneal surface is smooth and unremarkable. The lumen contains green mucoid bile as well as an oval, slightly lobulated. gallstone, measuring 2.7 x 1.6 x 1.5 cm. On fracturing the stone has a typical crystalline appearance of a cholesterol stone. The mucosa shows a focal sessile polypoid.
+
+--- Page 3 ---
+Page 3 of 4 area, 0.4 cm in greatest dimension, but is otherwise velvety and smooth and the gallbladder wall has a thickness of 0.2 cm.A small cystic duct lymph node, 0.7 cm in. greatest dimension is present adjacent to the cystic duct resection margin. Sections are taken as follows:. Al. resection margin with cystic duct lymph node as well as section from fundus A2. sections of body with small polypoid protrusions B. Specimen is received in formalin. The container is designated as " 8A node" and consists of a old fragment of firm, grey tan tissue, measuring 2.0 x 1.1 x 0.6 cm. Bisected and submitted in toto in one cassette.. c. The specimen is received fresh and is subsequently placed into formalin. The container is designated as  " Whipple specimen". This consists of a pancreaticoduodenectomy specimen, the segment of distal stomach and small bowel, measuring 17.0 cm in length. The head of pancreas measures approximately 5.0 x 4.5 x 3.5 cm. The neck of the pancreas is painted blue, the uncinate process margin is painted Orange. The mucosa of the duodenum is unremarkable with no tumor. The ampulla of Vater is unremarkable. The common bile duct is opened in the fresh state revealing a branching at the superior edge of the pancreas where the cystic c duct joins the common hepatic duct. The common bile duct, measures 3.5 cm in length. The attached portion of cystic duct, measures 2.7 cm and the attached portion of common hepatic duct, measures approximately. 1.0 cm.  The mucosal surface of the ducts are unremarkable. A coronal section into the head of pancreas reveals a firm tumorish mass occupying much of the head of pancreas,. with dimensions of 3.2 x 2.5 x 2.0 cm. The tumor appears to approach close to the inferior and uncinate margins, but small portion of pancreatic tissue superior to the. tumor and extending to the pancreatic neck resection margin has a fibrous consistency. The section of soft tissue around the head of pancreas reveals scatter lymph nodes.. Sections are taken as follows: C1. proximal resection margin common bile duct. C2. proximal resection margin cystic duct C3. pancreatic neck resection margin, en face C4-6. sections of ampulla of vater with underlying tumor. C7-10. tumor including uncinate margin and posterior soft tissue margin C1l. possible lymph nodes in a fatty tissue operative curvature. C12-14. three possible large lymph nodes along superior aspect of head of pancreas C15. three lymph nodes in gastroduodenal region C16. proximal resection margin/antral mucosa C17. gastroduodenal junction. C18/19. distal resection margin ducdenum Microscopic Description.  Sections show mild acute and chronic inflamnation involving the gallbladder with focal polypoid protrusions in the mucosa bed without any evidence of dysplasia or malignancy. The cystic duct lymph node shows slight granulomatosis and is negative for malignancy. B. Sections show lymph node tissue with lipogranulomatosis. There is no evidence of. malignancy. C.  There is an invasive well to moderately differentiated adenocarcinoma involving much of the head of the pancreas. The carcinoma invades through the muscularis propria in the. vicinity of the comnon bile duct, but does not reach the duodenal mucosa. The common bile duct mucosa is partly effaced by the invasive carcinoma. The tumor shows prominent perineural invasion and extends intc peripancreatic adipose tissue.  The tumor lies close. to the uncinate resection margin, but there is a narrow rim of fatty tissue with a clear margin of approximately 0.2 cm. 'The posterior retroperitoneal margin is clear as well. The pancreatic neck margin shows prominent fibrosis with loss of pancreatic tissue or
+
+--- Page 4 ---
+Page 4 of 4 chronic pancreatitis, possibly related to the development of carcinoma. No calcifications are present.  The section from the proximal bile duct and cystic duct margins show mild inflammation and reactive changes, but no sign of dysplasia or malignancy. The carcinoma invades directly into two peripancreatic lymph nodes regarded as positive for nodal involvement, although distant lymph nodes do not show tumor. Accession Number Encounter Number Patient Location -- End of printed report --
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diff --git a/output/text/6d48e211-dae3-4bf9-a799-05f517cb4ed6.txt b/output/text/6d48e211-dae3-4bf9-a799-05f517cb4ed6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6330090e56220a41a737ff27831603fb9516bc0f
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+ID63 ceel 8QkC/3 CGA-5P-A9K3-01A-PR Redacted Site: RKidruy No5 Cb4 y Papillary Renal Cell Carcinoma, Type Il, poorly differentiated Stage: pT2, pNX, pMX, R0 Grade: GIII ICD-0-Code: 8260/3 Laterairy - () h s/4j!y
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diff --git a/output/text/6d5720a8-e127-45f4-96d8-ca842d9989f3.txt b/output/text/6d5720a8-e127-45f4-96d8-ca842d9989f3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ab8f0e7de346a731f467b80f497f693ead8795fe
--- /dev/null
+++ b/output/text/6d5720a8-e127-45f4-96d8-ca842d9989f3.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1cs-o-3 Sreaot, Nos c50.9 Site : 4/111 Procurement Date Laterality:Left, upper outer quadrant Path RepOrt:BREAST TISSUE CHECKLIST Specimen type: Radical mastectomy Specimen size: Not specified Tumor site: Breast Tumor size: 2.7 x 2.7 x 2.5 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinoma Histologic grade: Tumor extent: Not specified Lymph nodes: 1/8 positive for metastasis (Axillary 1/8) Extracapsular invasion of the lymph nodes: Not specified Margins: Not specified Nottingham Histologic Score Tubule formation: Not specified. Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified UUID:672E4D81-DA47-495C-A58B-BD2B4FEA2380 TCGA-E9-A22H-01A-PR Redacted Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additiona! pathologic findings: Not specified Comments: None
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diff --git a/output/text/6d5c01da-d205-4eb0-9be4-898f5119fc09.txt b/output/text/6d5c01da-d205-4eb0-9be4-898f5119fc09.txt
new file mode 100644
index 0000000000000000000000000000000000000000..267dc4edf4e25833a68247f764adb8c203186470
--- /dev/null
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+
+--- Page 1 ---
+Accession Number: Report Status: Amend/Addenda Type: Surgical Pathology Specimen Type: Kidney, partial or total resection Procedure Date: Ordering Provide TCGA-CZ-5452 PATHOLOGIC DIAGNOSIS: A. SPECIMEN LABELED "RIGHT KIDNEY": RENAL CELL CARCINOMA, clear cell type (14.0 cm), Fuhrman grade II of IV. No extrarenal extension identified. No lymphovascular invasion identified. Ureteral, renal vein, and renal artery margins negative for tumor. AJcc classification (6th Edition): T2 NO MX. The non-neoplastic kidney will be evaluated by Renal Pathology, and the. findings will be reported in an addendum. B. SPECIMEN LABELED "REGIONAL LYMPH NODE": Five (5) lymph nodes negative for tumor. CLINICAL DATA History: old male with right varicocele. cT revealed large right renal. mass. Operation: Nephrectomy. Operative Findings: None given.. Clinical Diagnosis: None given.. TISSUE SUBMITTED: #1. Right kidney #2. Regional lymph node. GROSS DESCRIPTION: The specimen is received fresh, in two parts, each labeled with the patients name and unit number. Part A, labeled "right kidney", and consists of a 1,360 gram kidney (23.0 x 12. x 8.2 cm), with ureter (11.5 cm in length x 0.3 cm), renal vein (1.3 cm in length x 0.7 cm), and renal artery (2.0 cm in length x 0.4 cm in diameter). The soft tissue resection margin is inked black and the kidney is bisected to. reveal a multilobulated mass in the mid to lower pole (14.0 x 11.2 x 6.1 cm). The mass is predominantly tan/yellow with multiple hemorrhaqic foci. The tumor is less than 0.1 cm from the inked resection, 10.6 cm from the ureteral margin,. 1.8 cm from the renal vein margin, and 4 cm from the renal artery margin. The tumor grossly appears to abut the perirenal adipose tissue. The tumor grossly extends to but does not involve the renal pelvis. The remainder of the renal parenchyma demonstrates well-demarcated cortical medullary junctions and is electron microscopy, cytogenetic analysis, and tissue banking. A representative section of normal cortex is submitted for electron microscopy, immunofluorescence, and tissue banking. The specimen is photographed.. Representative sections are submitted. MIcRo Al: Ureter, rena vein, renal artery resection margin, 3 frags, MICRO A2: T1, 1 frag, MICRO A3: T2, 1 frag, MICRO A4: T3, 1 frag, MIcRo A5-A6: Tumor with soft tissue resection margin, 2 frags. MIcRo A7-A8: Tumor extending into perirenal fat frags, MIcRo A9: Tumor abutting renal pelvis,1 frag, MIcRo A10: Tumor with adjacent .and uninvolved rena parenchyma, 1 frag, MIcRo A11: Uninvolved renal parenchyma, 1 frag, Part B, labeled "regional lymph nodes", and consists of one fragment of adipose.
+
+--- Page 2 ---
+Accession Number: Report Status: Final Type: Cytogenetics CASE: C PATIENT: Cytogeneticist: TCGA-CZ-5452 KARYOTYPE: T1:44,xY,-3,add(6) (q13),-14,add(16) (q22),der(19) t(1;19)(q13;q21)[1]/ 46,XY [cp4] T2:41-44,X,-Y,-3,add(6) (q13),-14,add(16)'(q22) [cp5] METAPHASES COUNTED: 10 ANALYZED: 10 SCORED: 0 BANDING: GTG INTERPRETATION : Two different specimens of this specimen were karyotyped.. Clonal aberrations that included loss of the short arm of chromosome 3 (-3) were demonstrated in each of 5 cells from one specimen, and were also seen in 1 of 5 metaphase cells from the second specimen. Loss of chromosome 3 is a typical finding in renal cell carcinoma, clear cell type. COMMENTS : Mosaicism and small chromosome anomalies may not be detectable using the. standard methods employed. Chromosome analysis was performed at a ievel of 400 bands or greater. INDICATION FOR TEST: RCC
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diff --git a/output/text/6d65897b-acdf-492b-af6b-9d46ba05d760.txt b/output/text/6d65897b-acdf-492b-af6b-9d46ba05d760.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f37c63aa682199088f5a6c746f0e148baa864245
--- /dev/null
+++ b/output/text/6d65897b-acdf-492b-af6b-9d46ba05d760.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+UUID:E 55A-486A-A6AD~FCFED21629F2 TCGA-AC-A2FF-01A-PR Redacted Not for Permanent Storage in Medical Records / Not Valid for Signing Requesled by Patient MRN Date of Service Performing Facility Ordering Provider Result Provider 1cs-s-3 Report Name :Surgical Report camnona mnfttating 1o bulay nos 8580f3 Site breast, Nos C50.9 SEE REPORT ADDENDUM INFORMATION PROCEDURE DATE: - ADDENDUM REPORT #2; COMMENT: The panel of breast cancer markers was performed at using material from block B/BPc3. The results are sumnarized in part 3/BPC. Tine 10. I have seen the results and concur with the findings as stated.. T: *= ADDENDUM REPORT #2: DIAGNOSIS: A/APC & C.SEE ORIGINAL DIAGNOSES B/BPC. RIGHT BREAST MASS, EXCISION: 19.  SEE ORIGINAL DIAGNOSES 10.ANCILLARY STUDIES:  BREAST CANCER PROGNOSTIC PANEL: ASSAY RESULTS Staining Percent Test Name Intensity Positive Prognostic Assay Type Average Average Significance ER N/A 37% Favorable PR N/A 71% Favorable HER-2/neu 1.7 N/A Normal Limit Ki-67 N/A 18% 8orderline REFERENCE RANGES Test Favorable Border1ine Unfavorable ER >5% <5% PR >5% <5% Her2/neu <2.0 >2.0 <10% Ki-67 >10% - <20% >20% 11. SEE ORIGINAL DIAGNOSIS A-MAL IGNANT T: an ADDENDUM REPORT #1: cu.ENT: An immunostain for E-cadherin utilizing material fron block A is entirely. negative. This supports the light microscopic diagnosis of lobular carcinoma = ADDENDUM REPORT #1: DIAGNOSIS: = PENDING BREAST CANCER PANEL STUDIES ON B/8PC-3 A & APC. SENTINEL LYMPH NODE. RIGHT AXILLA: METASTATIC LOBULAR CARCINOMA
+
+--- Page 2 ---
+Not for Permanent Storage in Medical Records / Not Valid for Signing. Requested by: Patient MRN Date of Service Performing Facility Ordering Provider Result Provider Report Name :Surgical Report PRESENT IN ONIE LYMPH NODE: NEGATIVE E-CADHERIN IMMUNOSTAIN B & BPC. RIGHT BREAST MASS. EXCISION: 1. TUMOR TYPE: INFILTRATING LOBULAR CARCINOMA. SEE COMMENT BELOW  2 - 11.  SEE ORIGINAL DIAGNOSES SEE ORIGINAL DIAGNOSIS COMMENT : As noted. breast cancer marker studies will be performed on B/BPc-3.. A-MALIGNANT (Electronic S:gnature) SURGICAL PATHOLOGY REPORT PROCEDURE DATE: - SPECIMEN DESCRIPTION:- A. RIGHE AXILLARY SENTINEL LYMPH NODE, APC RIGHT BREAST BIOPSY. BPC C.  AXILLARY CONTENTS = PRE-OPERATIVE DIAGNOSIS: Right breast cancer -- POST-OPERATIVE DIAGNOSIS: Same = CLINICAL INFORMATION: Invasive ductal carcinoma in retroareolar space; right breast mass. - INTRAOPERATIVE CONSULTATION:: APC DIAGNOsiS: "Metastatic carcinoma," by Dr. BPC DIAGNOSIS: "Tissue obtained for genomics," by T: =- GROSS DESCRIPTION: - A. Received in formalin is an irregular tan-gray nodule. measuriny 2.0 x 1.6 x 0.5 cm. The specimen is bisected and entirely submitted in one cassette. APC. Received in formalin is an irregular portion of tan-gray soft tissue, measuring 1.5 x 1.5 x 0.2 cm. The specimen is entirely submitted in one cassette B/Bpc. Received in formalin is a portion of tan-yellow fibrofatty tissue, measuring 6.8 cm from medial to lateral. 6.7 cm fron superior to inferior. and 4.8 cm from anterior to posterior. The specimen is oriented as follows: short stitch - superior: long stitch - lateral. The anterior aspect is covered by skin, neasuring 5.0 x 3.0 x 0.2 cin. Centrally located on the skin surface is the nipple. measuring 1.0 x 1.0 x 0.8 cm. The cut surface of the nipple is tan and unremarkable. The specimen is inked as follows: superior -' blue: inferior - green: medial - red: 1ateral - yellow: anterior - orange: posterior. - black.  Sectioning from medial to lateral reveals a poorly-defined tan-gray.
+
+--- Page 3 ---
+Not for Permanent Storage in Medical Records / Not Valid for Signing Requested by Patient MRN Date of Service. Performing Facility Ordering Provider. Result Provider Report Name :Surgical Report tumor mass, measuring approximately 5.0 x 3.0 x 1.5 cm. This area is diffusely covered with blue radiographic dye. The cut surface is firm and gritty. The tumor mass blends into the adjacent thick fibrotic tissue. The tumor comes to within 1.0 cm of the medial margin. 0.2 cm of the lateral margin. 2.0 cm of the superior inargin, 0.7 cm of the inferior margin. 1.5 cm of the skin and nipple, and abuts the posterior margin. The renaining cut surface is composed of approximately 50% adipose tissue and 50% fibrous tissue. A biopsy cavity or metallic clip is not found. Representative sections are sequentially submitted. from nedial to lateral. in six cassettes as follows: cassette 1 - medial margin: cassette 2 - nipple with anterior aspect: cassette 3 - tumor mass with closest posterior margin: cassette 4 - tunor mass with superior margin: cassette 5 - tumor mass with inferior margin: cassette 6 - tumor mass with lateral margin. C. Received in formalin is an irregular portion of tan-yellow fatty tissue. measuring 5 x 4 x 2 cm. Six possible lymph nodes. ranging from 0.4 x 0.3 x 0.3 cm to 1.5 x 1.0 x 0.8 cm, are identified. The cut surface of the largest 1ymph node shows foci of tan-gray discoloration. The lymph nodes are entirely submitted in four cassettes as follows: cassette 1 - one intact and one bisected lymph node; cassette 2 - one lymph node: cassette 3 - two bisected lymph nodes (one inked black): cassette 4 - largest lynph node. ---= MICROSCOPIC DESCRIPTION: : A & APc. One slide is exanined for each portion of the case. Both slides demonstrate extensive lynph node involvement by poorly differentiated carcinona. Because of the obvious nature of this finding. it will not be necessary to perform a cytokeratin stain. B/BPc. Six slides are examined. Slide 1 show benign breast tissue without evidence of tumor involvement. The red inked medial margin is free of tumor. Slide 2 shows tissue from the region of the nipple. There is patchy ductal hyperplasia and no evidence of Paget's disease is evident. Slide 3 shows extensive infiltrating carcinoma with a pattern most suggestive of lobular carcinoma with periductal targetoid-like areas and nunerous foci of "Indian file" arrangement. On this slide, tunor is present approximately 0.1 mm to the black inked posterior surface. The tumor shows no evidence of tubular formation (tubules = 3). Nuclei exhibit occasional prominent nucleoli and these seem to be multiple in some scattered foci. In the most mitotically active areas of tumor, approximately eighteen to nineteen mitoses are present within ten high power field (mitoses - 2). The Nottingham score of this lesion is therefore 7 (3+3+2). making this a grade Il lesion. Slide 4 shows no evidence of malignancy. Slide 5 shows infiltrating carcinoma with a clear inferior green inked margin. Changes consistent with a prior biopsy site dre also present. No tumor is seen on slide 6. C. Four slides are examined. These show six lymph nodes. Positive lymph.
+
+--- Page 4 ---
+Not for Permanent Slorage in Hedical Records / Not Valid Tor Srgning Requested by  Pat ient MRN Date of Service Performing Facility Ordering Provider Resuit Provider Report Name :Surgical Report nodes are present on C1 and C3 for a total of two positive lymph nodes out of six. Including the sentinel lymph node in part A/APc. a total' of three out of seven lymph nodes are positive for metastatic carcinoma. FINAL DIAGNOSIS: ** (PRELIMINARY - PENDING BREAST CANCER PANEL STUDIES TO BE PERFORMED ON B/BPC-3) A & APC. SENTINEL LYMPH NODE, RIGHT AXILLA: METASTATIC CARCINOMA PRESENT IN ONE LYMPH NODE (1/1) B/BPC. RIGHT BREAST MASS. EXCISION: 1. TUMOR TYPE: INF ILTRATING CARCINOMA. MOST~LIKELY LOBULAR ^CARCINOMA, SE! COMMENT BELOW 2. NOTTINGHAM PROGNOSTIC INDEX: 7 (3+2+2). GRADE II 3. MAXIMUM INVASIVE TUMOR SIZE: GROSSLY ESTIMATED AT APPROXIMATELY 5 CM (pT2) 4. PERCENT DCIS: ZERO 5. LVI: NOT IDENTIFIED 6. DISTANCE TO CLOSEST MARGIN: APPROXIMATELY O.1 MM TO POSTERIOR INKED MARGIN (B/BPC-3 SLIDE) 7. MICROCALCIFICATIONS: NOT IDENTIFIED 8. LYMPH NODES: SEE PART C BELOW 9. TNM STATUS: pT2,N1,MX 10. ANCILLARY STUDIES: TO FOLLOW ON BLOCK B/BPC-3 11 OTHER FINDINGS: SEE REPUK1 SURGICAL PATHOLOGY REPORT PROCEDURE DATE : = FINAL OIAGNOSIS:  CHANGES CONSISTENT WITH PRIOR BIOPSY FOCAL FI8ROCYSTIC CHANGES OF REMAINING BREAST PARENCHYMA C. AXILLARY CONTENTS. RIGHT: METASTATIC CARCINONA IDENTIFIED IN TWO OF SIX AXILLARY LYMPH NODES. TOTAL 3/7 INCLUDING SENTINEL LYMPH NODE. AS ABOVE COMMEnr: As noted. breast cancer marker studies will be performed on B/BPc-3: in addition to confirm the lobular nature of this tumor, I will order an E-Cadherin immunostain on block A. A-MALIGNANT Srghaturt DATE AND TIME OF REPORT:
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diff --git a/output/text/6d92ab86-e039-47fa-9db6-2e7bfed12b76.txt b/output/text/6d92ab86-e039-47fa-9db6-2e7bfed12b76.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8778100b2c1acdfa5ff2aaf2d5e005026c4eacfe
--- /dev/null
+++ b/output/text/6d92ab86-e039-47fa-9db6-2e7bfed12b76.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis/ diagnoses: Resection material from (sigmoid) colon shows a colon carcinoma characterized histologically as a moderately differentiated colorectal adenocarcinoma, extending to within 6.5 cm of a resection margin at most and measuring 4 cm in diameter at the widest point. Infiltrative tumor spread within all parietal layers of the colon to the bordering mesocolic fatty tissue. In addition, the mucous membrane of the colon has a small tubulovillous adenoma with moderate epithelial dysplasia (synonym: low-grade epithelial neoplasia). The oral and aboral resection margins are tumor-free. Twenty-two mesocolic local lymph nodes are tumor-free with uncharacteristic reactive  lesions. The tumor stage is pT3 pN0 (0/22) L0V0; G2
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diff --git a/output/text/6da4a20c-0cfe-4419-90c2-ef1c867d400b.txt b/output/text/6da4a20c-0cfe-4419-90c2-ef1c867d400b.txt
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index 0000000000000000000000000000000000000000..ee6494d0f57b93b15a9c54fabb83ccaf4a63e6ef
--- /dev/null
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+
+--- Page 1 ---
+1cs-0- 3 Sitx:brsst, Nos C50.9 FOR OFFICIAL USE ONLY - PERSONAL DATA PRIVACY ACT OF 1974 UUID:B81555D4-78D9-4235-AABE-F852CA6F1585 lu TCGA-A2-A25E-01A-PR Redacted 4/27/n Patient: Specimen #: FMP/SSN: DOb/Age/Sex: (Age: F Race: Taken: Location: Received: Physician(s) : Reported: **AMENDED** SPECIMEN: LEFT BREAST MASTECTOMY AND AXILLARY CONTENTS FINAL DIAGNOSIS: A. BREAST,^LEFT) RADICAL MASTECTOMY: RESIDUAL INVASIVE DUCTAL CARCINOMA, MODERATELY DIFFERENTIATED BY COMBINED HISTOLOGIC CRITERIA, PRESENT IN THE AREA OF BIOPSY CAVITY AND LOWER OUTER QUADRANT ESTIMATED TUMOR SIZE BASED ON PREVIOUS NEEDLE LOCALIZATION BIOPSIES AT LEAST 3.0 CM. SEPERATE TUMOR MASS IN THE UPPER OUTER QUADRANT: INFILTRATING DUCTAL CARCINOMA, POORLY DIFFERENTIATED. TUMOR SIZE:2.0 CM (GROSS) MARGIN: TUMOR WITHIN IMM OF SUPERIOR SUPERFICIAL MARGIN  DUCTAL CARCINOMA IN SITU, INTERMEDIATE-GRADE, PREDOMINANTLY SOLID AND CRIBRIFORM TYPES. DEEP MARGIN:TUMOR (DCIS) EXTENDS WITHIN 1.O MM OF DEEP SURGICAL MARGIN IN ONE SECTION (SLIDE A12).  METASTASIS TO 6/1O AXILLARY LYMPH NODES WITH EXTRA CAPSULAR EXTENSION. SKIN AND NIPPLE NEGATIVE FOR CARCINOMA. - FIBROCYSTIC CHANGES. BIOPSY SITE CHANGES. - AJCC STAGE:T2N2MX commeNT:The amendment is made to report that there is a seperate tumor mass in the upper outer quadrant and also the deep margin status. The amendment is made in the absence of the primary pathologist. Page 1 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 2 ---
+FOR OFTICIAL US O PHRSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: FINAL DIAGNOSIS (continued): ** Report Electronicallv Sianed Out **. CLINICAL DIAGNOSIS AND HISTORY: Left breast carcinoma. GROSS DESCRIPTION: Received fresh is a 167 gm modified radical mastectomy specimen with the following measurements: breast 12.6 x 11.6 x 1.6 cm, overlying ellipse of nipple-bearing skin 7.2 x 5.5 cm, attached axillary contents 12.5 x 3.5 x 0.9 cm. Ink code: blue = superior superficial, green = inferior superficial, black = posterior. The skin is notable for a 2.0 cm well healed scar near the lateral edge of the ellipse. Examination of the axilla reveals multiple firm lymph nodes.A seperate mass is present in the upper outer quadrant measuring 2.0 x 1.4 x 1.4 cm. The breast is then serially sectioned revealing extensive white fibrous tissue with a 1.2 cm multiloculated biopsy cavity with associated hemorrhage and fat necrosis in the lower outer quadrant. Sections of the tumor mass and skin and breast samples for protocol with matching paraffin sections are follows: cassette Al grossly normal skin (medial tip), cassettes A2 and A3 2.0 cm tumor mass from upper outer quadrant, cassette A4 1.7 cm lymph node, high axilla (grossly positive), cassette A5 1.8 cm grossly normal lymph node, high axilia, cassette A6 biopsy cavity site, lower outer quadrant, cassette A7 grossly normal fibrous tissue, lower outer quadrant (approximately 2.0 cm from biopsy cavity) cassette A8 grossly normal fibrous tissue, upper outer quadrant, cassette A9 grossly normal fibrous tissue upper inner quadrant, cassette A1o grossly normal fibrous tissue lower inner quadrant, cassette All representative sections of nipple and scar from skin, cassette A12 biopsy cavity deep margin lateral, cassette A13 biopsy cavity superior medial, Al4 biopsy cavity inferior medial, Als four additional lymph nodes from axillary tail, Al6 two additional lymph nodes from axillary tail, cassette Al7 one lymph node bisected from axillary tail.. 4/374 Page 2 End of Report FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974S
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diff --git a/output/text/6da4c052-70dc-4102-b54b-b4569cf8de6e.txt b/output/text/6da4c052-70dc-4102-b54b-b4569cf8de6e.txt
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index 0000000000000000000000000000000000000000..47123c7c549436d3984acb35ea32557dcdadf73f
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+
+--- Page 1 ---
+A description for each data field can be found in the 'Data description' worksheet (yellow tab). Sample Collection Details  Histology ar Sample Number  Sample Sample Site of Site of Year of Age at  Sample Days to Type  PreparatioTissue  Primary Sample  Sample Comments Procedure n (Event) Collection Collection Date (yrs) TUMOUR FF Right kidney RENL BUFFY FF RENL
+
+--- Page 2 ---
+nd staging Days to Type of Site of Tumour  Histology Grade/ Pathologic Pathologic Diagnosis Procedure  Primary Size (cm) Differentiat al T. aI N (Histology) ion RESECT Right kidney II T3 NX 2.6 Papillary urothelial carcinoma RESECT Right kidney 2.6 Papillary urothelial carcinoma II T3 NX
+
+--- Page 3 ---
+Clinical M Histology Slide URL Comments
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diff --git a/output/text/6e04437f-7c30-4352-ad97-26c95b2ce0e0.txt b/output/text/6e04437f-7c30-4352-ad97-26c95b2ce0e0.txt
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index 0000000000000000000000000000000000000000..aa670778daf64d2857006e00b2d020ed3c0aa9fb
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+page 1 / 2 Department of Cancer Pathology copy No. Date: Examination: Histopathological examination Internal invoice No. Cost of diagnostic procedure Examination No.: Patient: xxx PESEL: XXX Age: Gender: F Material: Total organ resection - left breast. /cs-s-3 Unit in charge: Cacinona,nf1tnshng cunt,Nes 8500y Physician in charge: Sh? busst, nOS c50.9 Material collected on: 1 Material received on: ' 4/1s/1 Expected time of examination: up to 8 working days. Clinical diagnosis: Bifocal cancer of the left breast. Simple mastectomy. Examination performed on: Results of immunohistochemical examination: Focus marked as R1: Estrogen receptors found in over 75% of neoplastic cell nuclei. Progesterone receptors found in 10-75% of neoplastic cell nuclei.  HER2 protein stained using rabbit antibody Ventana PAThwAY HER-2/neu (4B5). Negative reaction in invasive cancerous cells (Score = 1+) Focus marked as R2: Estrogen receptors found in over 75% of neoplastic cell nuclei. Progesterone receptors found in 10-75% of neoplastic cell nuclei.  HER2 protein stained using rabbit antibody Ventana PATHwAY HER-2/neu (485). Negative reaction in invasive cancerous cells (Score = 1+) Compliance valid. Examination performed on: Macroscopic description: Carcinoma ductale bifocale - NHG2 (3 + 2+1:0 mitoses/ 10 HPF, visual area diameter: 0,55 mm) Carcinoma ductale in situ (Dcis) within the tumours (solid and cribrate type with high nuclear atypia, and point and comedo necrosis, 10% of the tumour areas). Invasio carcinomatosa vasorum.  In situ lesion of the type cancerisatio lobulorum.. Mamitla sine laesionibus. Glandular tissue showing parenchymal atrophy.. UUID:845F8FCF-CF3C-4CEF-B673-A57DE626939C TCGA-D8-A1XU-01A-PR Redacted #+?++
+
+--- Page 2 ---
+Examination: Histopathological examination page 2 / 2 Examination No.: PESEL: XXX Gender: F Patient: XXX Examination performed on: Histopathological diagnosis: Carcinoma ducale bifocale invasivum et in situ mammae sinistrae. invasive bifocal ductal carcinoma and carcinoma in situ of the left breast (NHG2, pTIc, pNO (SN). Invasio carcinomatosa vasorum. Vascular invasion. Compliance valida COnTaCT youR DOCtOR WIth THIS REPORt!
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diff --git a/output/text/6e099a59-92d6-4294-836b-ebefb5c308e5.txt b/output/text/6e099a59-92d6-4294-836b-ebefb5c308e5.txt
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index 0000000000000000000000000000000000000000..77f48284ae13a3b1be62aa9c4250f3f4746c14bb
--- /dev/null
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+
+--- Page 1 ---
+10D-0-3 Carciomu, mfi1tnnhng dluctcl, N0s 85oof3 Sih:Brst, Nos c50.9 1/19/hw Diagnosis:e 1. Invasive ductal breast carcinoma (maximum diameter 3 cm, conclusive malignancy grade III) with invasion of the lymph vessels in the tumor periphery and an invasive satellite node, as macroscopically documented. Remaining glandular body, which is rich in fatty tissue, is in involution. No calcification here and no DCIS formation. Tumor-free nipple. Wide safety margins. Tumor classification: pT2m pN2a (4/15), MX, R0; G3 (L1, V0). UUID:7DB1F816-A55F-449A-8DF9-6724B5100CA1 TCGA-A8-A08P-01A-PR Redacted
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diff --git a/output/text/6e0c599b-22d1-4f15-9875-ca6ec36bf262.txt b/output/text/6e0c599b-22d1-4f15-9875-ca6ec36bf262.txt
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index 0000000000000000000000000000000000000000..5538401192d315b1fe571256549e5f99e385e777
--- /dev/null
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+
+--- Page 1 ---
+Cannonn, engiltrahnj duct, nos 8500f3 12/29/10 Path h CQCF Sih: buast,Ns C5o9 TSS: UUID:C972EC08-E1AE-4FCB-B8A1-15000306CDE7 TCGA-E2-A14N-01A-pr Redactec SPECIMENS: A. SENTINEL NODE #1 RIGHT AXILLA B. RIGHT BREAST C. AXILLARY CONTENT D. LEFT BREAST REDUCTION SPECIMEN(S): A. SENTINEL NODE #1 RIGHT AXILLA B. RIGHT BREAST C. AXILLARY CONTENT D. LEFT BREAST REDUCTION INTRAOPERATIVE CONSULTATION DIAGNOSIS: TPA, FSA: Sentinel lymph node #1 right axilla: Smears (touch imprint)-Negative for tumor ceils, (trozen section)- Positive for carcinoma. By Dr, called to Dr. at GROSS DESCRIPTION: A. SENTINEL LYMPH NODE #1, RIGHT AXILLA Received fresh and labeled *sentinel node #1 right axilla" is a 2.8x1.0x1.2cm lymph node. There is blue dye staining present. The specimen is sectioned and a touch prep is pertormed. A portion of the lymph node is submitted for trozen section. The lymph node is submitted in toto as follows: FSA1: frozen section of portion of lymph node A2-A4: remainder of lymph node B.' RIGHT`BREAST,MASTECTOMY:  Received is a 1,321gm right mastectomy specimen measuring 23x23x5.8cm. Margin of specimen oriented with a stich indicating the lateral margin . In the medial portion of the specimen is an ellipse of tan skin measuring 6.7cm in length with a diameter of 3.1cm. Eccentrically located on the skin is a healed scar measuring 5.5cm in length. The areola is present and measures 4.0cm in length with a width of 3.0cm. The nipple is everted and is 1.0cm. The axillary tail is 6.5x5.0x1.5cm. The anterior surface of the specimen is inked blue, the posterior surface is inked black and the specimen is serially sectioned. In the upper inner quadrant is a well circumscribed white-tan mass  measuring 3.8x3.2x2.9cm which is located 0.5 cm from the nearest deep margin. The central portion of the mass shows areas of hemorrhage and possible necrosis. 4.6cm lateral from the mass, located approximately 2.0cm from the areola region, is a hemorrhagic white-tan tirm mass measuring 2.5x2.0x1.8cm. It is located 2.5cm from the deep margin. The remainder of the specimen consists of primarily adipose tissue. A few possible lymph nodes are found within the axillary tail. Multiple sections are submitted and labelled as foliows: follows: B1-10:sections from the larger tumor (medial ) B11-14: sections from the smaller tumor near nipple area.  B15-16 -- sections from upper inner quadrant  B17-18: sections trom upper outer quadrant B19-20: sections from lower outer quadrant. B21-22: sections from lower inner quadrant B23- 24 sections from nipple and areolar area.  B25-B26: possible lymph nodes C. AXILLARY CONTENTS Received in formalin and labeled "axillary contents levels 1&2" is a piece of adipose tissue, 7.3 x 5.6 x 0.9 cm. Multiple lymph nodes are found, ranging in size from 0.1 to 2.8cm. Lymph nodes are submitted in toto as follows: C1: 5 possible lymph nodes C2-C6: 4 possible lymph nodes, each C7: 2 possible lymph nodes C8: 3 possible lymph nodes C9-C10: 1 bisected lymph node, each C11-C13: 1 lymph node each D. Left Breast reductIOn: Received in formalin and labeled *, Left Breast Reduction mammoplasty". The specimen consists of primarily. adipose tissue, little tibrous breast tissue is found. No masses or lesions are seen. Representative sections are submitted as follows: D1 skin and subjacent adipose tissue, D2-D3 fibrous tissue. DIAGNOSIS: A. SENTINEL NODE #1, RIGHT AXILLA: - METASTATIC CARCINOMA TO ONE OUT OF ONE LYMPH NODE, CONSISTENT WITH METASTASIS FROM PRIMARY BREAST CARCINOMA. (1/1) see note. B. RIGHT BREAST, MASTECTOMY SPECimEN: : .  - INVASIVE DUCTAL CARCINOMA, SBR GRADE II WITH GEOGRAPHIC AREAS OF NECROSIS MULTICENTRIC.
+
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+- SIZE OF TUMOR:MEDIAL ASPECT OF BREAST-3.8 x 3.2 x 2.9 CM. - CENTRAL AREA - SIZE OF TUMOR-2.5 x 2.0 x 1.8 CM. - MARGINS OF RESECTION-NEGATIVE FOR TUMOR. - FOCAL COLUMNAR CELL CHANGE. - TWO AXILLARY LYMPH NODES-NEGATIVE FOR TUMOR (0/2). C. AXILLARY CONTENTS, RESECTION: - THIRTY-FIVE AXILLARY LYMPH NODES-NEGATIVE FOR TUMOR (0/35). D. LEFT BREAST REDUCTION: - BREAST TISSUE WITH INCLUDED SKIN TISSUE-NO SPECIFIC PATHOLOGIC CHANGES-NEGATIVE FOR TUMOR.  NOTE: In specimen A,(A1) size of lymph node measured 2.8x1.0x1.2cm and metastatic tumor only seen on the portion of lymphnode submitted for frozen and permanent section in an area measuring 5.0x2.5mm. The remainder of the lymph node submitted as A2-A4 are negative for metastatic tumor. SYNOPTIC REPORT - BREAST Specimens Involved Specimens:  A: SENTINEL NODE #1 RIGHT AXILLA B: RIGHT BREAST C: AXILLARY CONTENT D: LEFT BREAST REDUCTION Specimen Type: Mastectomy Needle Localization: No Laterality: Right  Invasive tumor: Present Multifocality: Yes WHO CLASSIFICATION  Invasive ductal carcinoma, NOS 8500/3 Specimen size: Size of Invasive tocus 3.8cm Additional dimensions: 3.2cm x 2.9cm Tumor Site: Upper inner quadrant Central Margins:  Negative Distance from closest margin:. 0.5cm Margin: deep Tubular score: 3 (<10% tubule)  Nuclear grade: 3 Mitotic score (Olympus 40x): 3 (>13/10 hpf)  Modified Scarff Bloom Richardson Grade: 8-9 points) Necrosis: Present Vascular/Lymphatic Invasion: None identified Lobular neoplasia:  None Lymph nodes: Sentinel lymph node and axillary dissection Lymph node status: Positive 1 / 38 Micrometastases: No DCIS PRESENT? No Pathological staging (pTN) pT 2 N 1 CLINICAL HISTORY:  year old with right breast ca PRE-OPERATIVE DIAGNOSIS: Right breast ca ADDENDUM: BREAST ER/PR -1 SPECIMEN Type: Other Mastectomy Block Number: B9  HORMONE RECEPTOR STATUS Laboratory: Estrogen Receptor: Negative Allred Score: 0 = Proportion Score 0 + Intensity Score 0
+
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+Progesterone Receptor: Negative Allred Score: 0 = Proportion Score 0 + Intensity Score 0 The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity ot staining), with a scoring range from 0 to 8.. ER/PR positive is detined as an Allred score of >2 and ER/PR negative is detined as an Allred score of less than or equal to 2. Methodology: Fixation Type and Length: Tissue was fixed in 10% neutral buffered formalir.. CT) for no less than 8 and rc Irger than 24 hours. Antibody and Assay Methodology: Mouse anti-human n ana PR, Comment: This assay can be used to select invasive breast cancer patients for hormone therapy (1). ER and PR analysis was performed on this case by immunohistochemistry utilizing the ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) antibody provided by , following the manufacturer's instructions listed in the package insert. This assay was not moditied, and adherence to all instruction and guidelines were strictly followed. Interpretation of the ER/PR immunohistochemical staining characteristics is guided by published results in the medical literature (1), information provided by the reagent manutacturer and by internal review of staining performance within Pathology Department. 1. Harvey JM, et al. Estrogen receptor status by immunohistochemistry is superior to the ligand-binding assay for predicting response to adjuvant endocrine therapy in breast cancer. J Clin Oncol. 17:1474-1481, 1999 SYNOPTIC REPORT - BREAST HER-2 RESULTS Specimens Involved Specimens:  B: RIGHT BREAST HER2 Status Resuits, Immunohistochemistry Evaluation SPECIMEN Surgical Excision Block Number: Block 89 Interpretation: Negative Intensity: 0 % Tumor Staining: 0% FISH Ordered NO METHODOLOGY Methodology: Fixation Type and Length: Tissue was tixed in 10% neutral butfered formalin. ' for no less than 8 and no longer than 24 hours. Antibody and Assay Methodology: Rabbit anti-human HER2, HerceptestTM (FDA-approved test kit), (: '4). Control Slides Examined: External kit-slides  provided by manufacturer (cell lines with nign, low and negative HER2 protein expression), and in-house known HER2 amplified control tissue were evaluated along with the test tissue. These control slides run along side of this patient's sample showed appropriate staining. Adequacy ot Specimen: Adequate, well preserved, clear-cut invasive carcinoma identified for HER2 evaluation. Scoring Criterion and Scoring System: IHC Level of Expression(Score) /Tumor Cell Membrane Staining Pattern Negative (0)/Absence of Staining Negative (1+)/Faint Incomplete membrane Staining, >10% of Cells Equivocal (2+)/Weak complete membrane Staining, >10% of Cells Positive (3+)/Strong complete membrane Staining, >10% of Cells Equivocal Category for HER2 IHC results: A HER2, 2+ staining result that is interpreted as equivocal may not indicate gene amplification. A FISH test for HER2 gene amplification will be ordered for all HER2 IHC 2+ results. COMMENT This assay can be used to select invasive breast cancer patients tor Trastuzumab (Hereptin) therapy (1,2). Clinica! Trials have shown that Trastuzumab substantially increases the likelihood for an objective response and overal! survival for patients with metastatic HER2-positive breast cancer, regardless of whether HER2 tumor status was determined as IHC 3+ or FISH positive. Trastuzumab added to adjuvant chemotherapy substantially increase  disease-free survival and decreases the risk of disease recurrence by about 50% for patients with early-stage HER2 protein over-expressed or gene amplified invasive breast cancer (3). HER2 analysis was performed on this case by immunohistochemistry utilizing the FDA approved Dako HercepTest (TM) test kit following the manufacturer's instructions listed in the package insert. This assay was not modified, and  adherence to all instruction and guidelines were strictly followed. Interpretation of the HER2 immunohistochemical  staining characteristics is guided by published results in the medical literature (4), information provided by the reagent manufacturer and by internal review of staining performance within the Pathology Department. HER2 TEST VALIDATION This HER2 immunohistochemical assay has been validated according to the recently revised recommendations and  guidelines from the NCCN HER2 testing in Breast Cancer Task Force, and the jointly issued recommendations and  guidelines trom ASCO and the CAP (5). 80 randomly selected breast cancer samples were tested for HER2 by IHC  as outline above and interpreted as, negative (score 0/1+) equivocal (score 2+) and positive (score 3+) without knowledge of the previous reported results. These cases were also blindly read using two different FiSH assay as amplified or non-amplified and the. HER2/CEP17 ratios were recorded. After analyzing these results, there was 100% concordance between the IHC
+
+--- Page 4 ---
+and FISH results tor cases that were interpreted as either positive or negative by IHC. 9 of the 80 cases were interpreted as equivocal by IHC and of these 3/9 (33%) were non-amplified by FISH and 6/9 (66%) were found to be amplified. The Pathology Department Immunohistochemistry laboratory takes full responsibility for this tests performance and has programs in place to regularly monitor the proficiency and the interpretation of HER2 assays. The laboratory also participates in external quality assurance HER2 programs including the CAP proficiency testing program. REFERENCE 1. Carison Rw, Anderson BO, Burstein HJ, et al., NCCN breast cancer clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2005;3:238-289. 2. Carson Rw, Brown E, Burstein HJ, et ai., NCCN Task Force Report: adjuvant therapy for breast cancer. J Natl Compr Canc Netw. 2006;4:S1-S26. 3. Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Eng J Med 2005;353(16):1673-84 4. Leong ASy, Formby M, Haffajee Z, et al. Retinement of immunohistologic parameters tor Her2/neu scoring validation by FiSH and CISH. Appl Immunohistochem Mol Morphol. 2006;14:384-389. 5. Wolff AC, Hammond EH, Schwartz JN, et al., American Society of Clinical Oncology/Coilege of American Pathologists Guideline Recommendations for Human Epidermal Growth Factor Recepto 2 Testing in Breast Cancer. Arch of Path and Lab Med 2007; 131:18-43. Immunostain results done on the smaller second tumor (section B11) are as follows: ER: Negative (0%) PR: Negative (0%) SYNOPTIC REPORT - BREAST HER-2 RESULTS HER2 Status Results, Immunohistochemistry Evaluation SPECIMEN  Surgical Excision Block Number: Block B1 Interpretation: Equivoca! Intensity: 2+ % Tumor Staining: 20% FISH Ordered YES DATE METHODOLOGY Methodology: Fixation Type and Length: Tissue was fixed in 10% neutral buffered formalin. for no less than 8 and no longer than 24 hours. Antibody and Assay Methodology: Rabbit anti-human HER2, HerceptestTM (FDA-approved test kit), . Control Slides Exanined: External kit-slides provided by manufacturer (cell lines witn nign, iow and negauve rER2 protein expression), and in-house known HER2 amplified control tissue were evaluated along with the test tissue. These control slides run along side of this patient's sample showed appropriate staining. Adequacy of Specimen: Adequate, well preserved, clear-cut invasive carcinoma identified for HER2 evaluation. Scoring Criterion and Scoring System:. IHC Level of Expression(Score) /Tumor Cell Membrane Staining Pattern Negative (O)/Absence of Staining Negative (1+)/Faint Incomplete membrane Staining, >10% of Cells Equivocal (2+)/Weak complete membrane Staining, >10% of Celis Positive (3+)/Strong complete membrane Staining, >10% of Cells Equivocal Category for HER2 IHC results: A HER2, 2+ staining result that is interpreted as equivocal may not indicate gene amplitication. A FISH test tor HER2 gene amplification will be ordered for ali HER2 IHC 2+ resuits. COMMENT This assay can be used to select invasive breast cancer patients for Trastuzumab (Hereptin) therapy (1,2). Clinical  Trials have shown that Trastuzumab substantialy increases the likelihood for an objective response and overall  survival for patients with metastatic HER2-positive breast cancer, regardless of whether HER2 tumor status was determined as IHC 3+ or FiSH positive. Trastuzumab added to adjuvant chemotherapy substantially increase  disease-free survival and decreases the risk of disease recurrence by about 50% for patients with early-stage HER2 protein over-expressed or gene amplitied invasive breast cancer (3). HER2 analysis was performed on this case by immunohistochemistry utilizing the FDA approved Dako HercepTest (TM) test kit following the manufacturer's instructions listed in the package insert. This assay was not modified, and adherence to all instruction and guidelines were strictly followed. Interpretation of the HER2 immunohistochemical  staining characteristics is guided by published resuits in the medical literature (4), information provided by the reagent manufacturer and by internal review of staining performance within the Pathology Department. HER2 TEST VALiDATION This HER2 immunohistochemical assay has been validated according to the recently revised recommendations and guidelines from the NCCN HER2 testing in Breast Cancer Task Force, and the jointly issued recommendations and guidelines from ASCO and the CAP (5). 80 randomly selected breast cancer samples were tested for HER2 by IHC  as outline above and interpreted as, negative (score 0/1+) equivocal (score 2+) and positive (score 3+) without knowledge of the previous reported results.
+
+--- Page 5 ---
+These cases were also blindly read using two different FiSH assay as amplified or non-amplified and the HER2/CEP17 ratios were recorded. After analyzing these results, there was 100% concordance between the IHC  and FiSH results for cases that were interpreted as either positive or negative by IHC. 9 of the 80 cases were interpreted as equivocal by IHC and of these 3/9 (33%) were non-amplified by FISH and 6/9 (66%) were found to be amplified. The Pathoiogy Department Immunohistochemistry laboratory takes full responsibility tor this tests performance  and has programs in place to regularly monitor the proficiency and the interpretation of HER2 assays. The laboratory also participates in external quality assurance HER2 programs including the CAP proficiency testing program. REFERENCE 1. Carison RW, Anderson BO, Burstein HJ, et al., NCCN breast cancer clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2005;3:238-289. 2. Carison Rw, Brown E, Burstein HJ, et al., NCCN Task Force Report: adjuvant therapy for breast cancer. J Nat! Compr Canc Netw. 2006;4:S1-S26. 3. Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Eng J Med 2005;353(16):1673-84 4. Leong ASy, Formby M, Haffajee Z, et al. Refinement of immunohistologic parameters for Her2/neu scoring validation by FISH and CiSH. Appl Immunohistochem Mol Morphol. 2006;14:384-389. 5. Wolff AC, Hammond EH, Schwartz JN, et al., American Society of Clinical Oncology/College of American. Pathologists Guideline Recommendations for Human Epidermal Growth Factor Recepto 2 Testing in Breast Cancer. Arch ot Path and Lab Med 2007; 131:18-43. Gross Dictation: Microscopic/Diagnostic Dictation: Patholoaist Final Review: Pathologist, Microscopic/Diagnostic Dictation: Pathologist,  Microscopic/Diagnostic Dictation: Pathologist. Final Review: Pathologist, Final: Pathologist, Addendum: Pathoiugist, Addendum Review: Pathologist. Addendum Final: Pathologist, Addendum: PATHOLOGIST, Addendum Review: PATHOLOGIST Addendum Final: PATHOLOGIST. Addendum: Pathologist Addendum Review: Pathologist. Addendum Final: Pathologist,. Addendum: PATHOLOGIST, ( Addendum Review: PATHOLOGIST, ? Addendum Final: PATHOLOGIST, f
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diff --git a/output/text/6e1f706d-db6f-491c-9dd3-ad203fd02a86.txt b/output/text/6e1f706d-db6f-491c-9dd3-ad203fd02a86.txt
new file mode 100644
index 0000000000000000000000000000000000000000..03e00a022ce37d330eb25ed6dd413fd87a4eadc8
--- /dev/null
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@@ -0,0 +1,6 @@
+
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+COPY TO: Pre-Op Diagnosis Dysplastic colon polyp, colon mass Post-Op Diagnosis Same Clinical History Nothing indicated on requisition Gross Description: Container labeled " - extended right colon" is a 28.5 cm previously opened portion of large bowel including cecum and 3.0 cm of attached previously partially opened terminal ileum. The specimen is covered by a moderate amount of pericolic and epiploic adipose tissue in which a 4.9 x 0.7 x 0.7 cm grossly unremarkable vermiform appendix is identified. The visible serosa is smooth and gray tan. Noted at a point approximately 4.6 cm from the distal margin there is an area of deep gray discoloration consistent with tattooing. The bowel wall is up to 0.6 cm, edematous, and fibrotic. The lumen is lined by gray tan mucosa with preservation of intestinal folds. Noted in the area with the tattooing at a point 4.8 cm from the distai margin there is a previously partially sectioned 2.6 x 2.0 cm slightly raised finely granular centrally ulcerated gray brown plaque-like lesion. On sectioning this has a tan gritty fibrotic cut surface and grossly extends through the muscle but appears limited by the serosa. No other gross lesions are identified. Sectioning the surrounding adipose tissue reveals a few poorly defined tan gray to pink nodules up to 0.6 cm. Also received in the same container are three tissue cassettes each labeled  Representative sections are submitted. labeled as tollows: A - proxmal margin, B - distal margin, C through F - entire remaining lesion on surrounding tissue, G - random uninvolved bowel, H - appendix, 1 through K - nodules from pericolic fat.
+
+--- Page 2 ---
+Microscopic Description: The slides labeled are examined. See diagnosis Final Diagnosis. Terminal ileum, appendix, and right colon: Terminal ileum: No carcinoma is identified. PAS 1 Appendix: Fibrous obliteration of the luminal tip, no carcinoma identified. PAS 4 Colon: Tumor characteristics:e Histologic type: Adenocarcinoma.. Location of tumor: 4.8 cm from the distal surgical margin.. Size: 2.6 x 2.0 cm in greatest dimension. Grade: Moderately differentiated.. Lymphovascular space invasion: No unequivocal lymphovascular  space invasion identified. Perforation of Visceral peritoneum: No Presence of mesenteric deposits: No. Depth of invasion: Carcinoma extends through muscularis propria focally into subserosal adipose tissue. Surgical Margin Status:. Proximal Margin: No carcinoma identified. Distal Margin: No carcinoma identified. Radial Margin: No carcinoma identified. Distance of tumor from closest mucosal surgical margin: 4.8 cm. Lymph Node Status: Total number of lymph nodes examined: 12 Total number of lymph nodes with metastatic carcinoma: 0 (0/12) PAS 9 Other: Macrophages containing brownish black cytoplasmic pigment consistent with prior tattoo. PAS2 SPC-NP Stage: pT3N0 CPT: 88309 Comments At the request of the undersigned pathologist, these slides have been additionally reviewed by Dr.  * who concurs with the diagnosis.
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diff --git a/output/text/6e263825-3c0c-4c12-b572-977fdafdb6ce.txt b/output/text/6e263825-3c0c-4c12-b572-977fdafdb6ce.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3ab3043115bfeceac3984a661c5371961bbc8cce
--- /dev/null
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@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+with history of rectal cancer. Specimens Submitted: 1: COLON, SIGMOID; RESECTION: 2: SP: Proximal ring 3: SP: DIstal ring DIAGNOSIS: 1. COLON, SIGMOID; RESECTION: : Tumor Type: Adenocarcinoma Histologic Grade: Moderately differentiated Tumor Location: Sigmoid colon Tumor Size: Length is 6.5 cm Width is 4.5 cm Maximal thickness is 2.5 cm Tumor Budding: Absent Increased Tumor Infiltrating Lymphocytes: Absent Precursor Lesions: Tubulovillous adenoma Deepest Tumor Invasion: Muscularis propria Gross Tumor Perforation: Not identified Lymphovascular Invasion: Not identified Large Venous Invasion: Not Identified Perineural Invasion: Not identified Surgical Margins: Free of tumor Polyps/Mucosa Dysplasia (away from the carcinoma): Tubular adenoma; number: 1 ** Continued on next page **
+
+--- Page 2 ---
+Non-Neoplastic Bowel: Unremarkable Lymph Nodes: Number with metastasis: 0. Total number examined: 31. Tumor c deposits in pericolorectal soft tissue: Not Identified Tumor Staging (AJcc 7th Edition): pT2 (Tumor invades muscularis propria) Lymph Node Stage (AJcc 7th Edition): N0 (No regional lymph node metastasis) NOTE: RESULTS OF IMMUNOHISTOCHEMICAL STAINING FOR DNA MISMATCH REPAIR PROTEINS ARE AS FOLLOWS: MLH1: STAINING PRESENT IN TUMORS MSH2: STAINING PRESENT  IN TUMOR MSH6: STAINING PRESENT IN TUMORS PMS2: STAINING PRESENT IN TUMORS CONCLUSION:IMMUNOHISTOCHEMICAL STAINING FOR THE TESTED DNA MISMATCH REPAIR PROTEINS IS RETAINED IN THE TUMOR. 2. COLON, PROXIMAL RING; EXCISION: BENIGN COLONIC TISSUE. A DETACHED FRAGMENT OF ADENOMATOUS MUCOSA IS NOTED. 3. COLON, DISTAL RING; EXCISION: - BENIGN COLONIC TISSUE. Some of the immunohistochemistry and Ish tests were developed and their performance characteristics were determined by the Department of Pathology.. They have not been cleared or approved by the Us Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Gross Description: 1. The specimen is received fresh and is labeled "Sigmoid". It consists of. an undesignated sigmoid colon (19.5 cm in length and ranges in circumference. from 6.2 to 8.0 cm) with attached pericolonic fat (17.3 x 8.5 x 2.5 cm). The. ** Continued on next page **
+
+--- Page 3 ---
+serosal surface is pink, glistening and intact. The presumed distal resection margin is inked black and presumed proximal resection margin is inked red. The specimen is opened to reveal an exophytic, bosselated, tumor (6.5 cm in length and 4.5 cm in width) that is located 10.0 cm from the proximal margin and 4.5 cm from the distal margin. Serial sectioning reveals the tumor has a depth of 2.5 cm. Thorough sectioning show that the tumor appears to be limited to the muscularis propria without invasion beyond the muscle. There is 2nd tan polypoid mass , located 1.5 cm from the tumor which is sampled. The remaining mucosa is grossly unremarkable. Pericolic and perirectal adipose tissue is thoroughly examined for lymph nodes, and all possible nodes are submitted. Representative sections are submitted. The tumor area is extensively sampled. Tps is submitted.. Summary of sections: PM - proximal margin, shave DM - distal margin, shave T tumor P- polypoid mass. U - uninvolved mucosa LN - lymph nodes BLN bisected lymph node TU more sections from the tumor. 2. The specimen is received in formalin, labeled "proximal ring" and consists of a silver metal anastomotic pin measuring 7.5 x 2.8 x 1.5 cm. At the center of the pin, a blue plastic piece is noted. A ring of pink tan soft tissue is attached measuring 2.3 x 2.2 x 1.1 cm. The mucosal surface is pink tan and focally hemorrhagic and the serosal surface is pink tan and smooth. Several sutures and staples are noted. The sutures and staples are. removed and the soft tissue is entirely submitted. Summary of sections: U--undesignated 3. The specimen is received in formalin, labeled "Distal ring" and consists of a ring of pink tan soft tissue measuring 2.2 x 1.9 x 0.8 cm..  Multiple sutures and staples are attached..  The mucosal surface is pink tan and. focally hemorrhagic. The sutures and staples are removed and the soft tissue is entirely submitted. Summary of sections:. U--undesignated Summary of Sections: Part 1: COLON, SIGMOID; RESECTION: ** Continued on next page **
+
+--- Page 4 ---
+Page 4 of 4 Block Sect.  Site PCs BLN DM Ln 11 P 1 PM 2 11 TU 14 1 1 Part 2:  SP: Proximal ring Block Sect. Site PCs 1 U 8 Part 3: SP: DIstal ring Block Sect. Site pCs 1 U 5 ** End of Report
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diff --git a/output/text/6e3a3e1d-2e9d-4d29-8603-d927cb615861.txt b/output/text/6e3a3e1d-2e9d-4d29-8603-d927cb615861.txt
new file mode 100644
index 0000000000000000000000000000000000000000..bdcc25e509a33d174ef7f78102ebca9effb37d85
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+
+--- Page 1 ---
+Encounter Date: Results SURGICAL PATHOLOGY (Order) Patient Info Patient Name Sex DOB Female Results iCD-o-3 UUID:C6248F9C-58D2-4F68-9D45-B38F38DCCA530 carcinoma,ur0+h<Jia),n0S TCGA-GV-A30K-01B-PR Redacted Spe gl a0f3 Sut Si*: biaddkr,N0s C47.9 75iz k0 FINAL DIAGNOSIS 1. Right colon, segment of terminal ileum and appendix, colectomy (A) - Single focus of metastatic urothelial carcinoma present within subserosal. lymphovascular space.  Segment of colon with mild crypt architectural distortion and submucosal. fibrosis, consistent with prior biopsy site changes; no evidence of residual dysplasia or adenocarcinoma. - Submucosal lipoma. - Appendix and small bowel with no specific diagnostic alteration. -Thirty-three pericolonic lymph nodes, negative for carcinoma (0/33). - See comment. 2. Right distal ureter, excision (B) - Benign portion of ureter, negative for urothelial dysplasia/carcinoma. 3. Left distal ureter, excision (c) - Benign portion of ureter, negative. for urothelial dysplasia/carcinoma. 4. Urethral margin, excision (D) - Benign urethral tissue, negative for urothelial dysplasia/carcinoma. 5. Urinary bladder, uterus, cervix, and vagina, anterior exenteration - Bladder with invasive high grade papillary urothelial carcinoma, extending through the perivesical fat and into the stroma of the endocervix and lower uterine segment myometrium, as well as into the vaginal submucosa (see comment). -Lymphvascular invasion is identified. -Perineural invasion is identified. -Carcinoma extends to the inked posterior serosal surface of the bladder. -Vaginal margin is negative for carcinoma. -Ureteral and urethral margins are negative for carcinoma. -Urothelial carcinoma in situ is identified in the bladder mucosa. -Unremarkable uterine cervical mucosa. -Inactive endometrium. 6. Urethral margin #2, excision (F) - Benign portion of urethra, negative for urothelial dysplasia/carcinoma. 7.  Lymph nodes, right pelvic, excision (G) - Fourteen lymph nodes negative for carcinoma (0/14). 8. Lymph nodes,. left pelvic, excision (H) - Metastatic urothelial Page 1 of 5
+
+--- Page 2 ---
+Encounter Date carcinoma involving five of twenty-three lymph nodes (5/23). - Extranodal extension is identified. COMMENT 1. (A) The entire previous biopsy site and colonic tissue adjacent to it were submitted for histologic evaluation. There is no evidence of residual. dysplasia or invasive adenocarcinoma in this specimen. Slides from part A Of this case were reviewed with Dr.. 5. Procedure: Anterior exenteration Tumor Size (greatest dimension): 5.0 cm Histologic Type: Urothelial carcinoma Associated Epithelial Lesions:. Urothelial carcinoma in situ Histologic grade: Urothelial Carcinoma (WHO High-grade ) : Microscopic Tumor Extension: Perivesical fat Myometrium Endocervical stroma Vaginal submucosa Margins: Margins uninvolved by invasive carcinoma.. posterior serosal surface of the bladder.. Carcinoma extends to the inked. Ureteral margins, urethral margin, and vaginal margin negative for. carcinoma. Lymphovascular Invasion : Present Pathologic Stage (TNM): Number lymph nodes examined: 37. Number lymph nodes involved (any size): 5. Primary Tumor (pT) pT4a Regional Lymph Nodes (pN)  pN2 Distant Metastasis (pM):. pMX Slides from the cystectomy specimen were reviewed at the. with Drs. and Paae ? af5
+
+--- Page 3 ---
+Encounter Date: M.D. (Electronic Signature) SPECIMEN SUBMITTED A: RIGHT COLECTOMY B: RIGHT DISTAL URETER C: LEFT DISTAL URETER D: URETHRAL MARGIN E: BLADDER, UTERUS AND CERVIX F: URETHRAL MARGIN #2 G: RIGHT PELVIC LYMPH NODES H: LEFT PELVIC LYMPH NODES CLINICAL DATA BLADDER CA INTRAOPERATIVE CONSULT DIAGNOSIS B. Negative for carcinoma (Dr. ). c. Mostly denuded epithelium, negative for carcinoma (Dr. D. Negative for carcinoma, however, no epithelium identified (Dr. F. Negative for carcinoma (Dr. GROSS DESCRIPTION A. Received fresh labeled "right colon" is a 14.5 cm segment of right colon with an attached 9 cm segment of terminal ileum. An appendix is identified. The serosal surface is smooth and glistening. The wall of the colon averages 0.3 cm in thickness. The wall of the terminal ileum averages 0.2 cm in thickness. The mucosa of the colon demonstrates a brown-yellow submucosal nodule measuring 1.3 x 1.3 cm located 5.4 cm from the distal margin. Sectioning reveals a yellow homogenous cut surface. It does not invade the underlying wall. Multiple soft white polyps are identified ranging in size from 0.1 to 0.4 cm. All appear superficial. In the ascending colon, there is an irregular red slightly depressed area resembling a possible biopsy site measuring 0.8 x 0.2 cm located 14 cm from the distal margin. It is superficial and does not invade into the underlying wall. The remaining mucosa is unremarkable. No firm mass lesions are identified. The mucosa of the terminal ileum is unremarkable. The attached appendix measures 4.7 cm in length and 0.9 cm in diameter. The lumen is dilated to 0.2 cm and contains fecal material. No perforations or ulcerations are seen. Sectioning through the surrounding fibroadipose tissue reveals multiple ovoid tan firm nodules resembling lymph nodes. Representative sections are submitted as follows: Al margins (proximal margin blue, distal margin orange). A2-A3 submucosal nodule totally submitted, A3 biopsy site totally submitted, A4-A5 polyps totally submitted, A6 appendix, A7 ileocecal valve, A8 small bowel, A9-A17 lymph nodes. B. Received fresh at the frozen desk labeled #right distal ureter" is a 0.3 cm in diameter, 0.2 cm in length luminal tan-pink soft tissue fragment. The specimen is totally submitted for frozen section in one cassette labeled B1. Page 3 of 5
+
+--- Page 4 ---
+Encounter Date: C. Received fresh at the frozen desk labeled "left distal ureter" is a 0.3 cm in diameter, 0.2 cm in length tan-pink luminal soft tissue fragment. The specimen is totally submitted for frozen section in one cassette labeled C1. D. Received fresh at the frozen desk labeled "urethral margin" is a 2 x 0.6 x 0.3 cm red-tan mucosal lined soft tissue fragment. The specimen is totally submitted for frozen section in one cassette labeled D1.. E. Received in formalin is a specimen consisting of a urinary bladder, bilateral ureters, uterus, attached cervix, and portion of vagina. The bladder measures 6.0 x 4.5 x 4.2 cm. The external surface of the bladder is covered by a smooth serosal lining at the dome and fibroadipose tissue at the remaining portion. After the bladder is opened, a tan fungating mass is identified in the right anterior bladder wall extending to the left and right trigone region measuring 5.0 x 3.1 x 1.2 cm. Upon multiple cross sections there does appear to be gross extension beyond the bladder wall extending to within 0.2 cm of the soft tissue margin. Also, identified on the left bladder wall is an ulcerated indurated area of mucosa measuring 4.2 x 3.0 cm. This area of this bladder wall extends posteriorly and is associated with a thickened bladder wall measuring up to 2.0 cm. The bladder wall grossly appears to be involved by a mass which extends beyond the bladder wall, approaching the soft tissue margin. The right ureter measures 5.0 cm and is unremarkable. The left ureter measures 6.0 cm and is also unremarkable. The uterus measures 6.0 x 3.5 x 3.5 cm, and weighs 53.2 grams. A section of vaginal cuff and vagina are present measuring 5.0 x 1.2 cm. The vaginal mucosa is unremarkable. The ectocervix is unremarkable. The endocervical canal measures 1.8 cm in length. Polyps are not present. The endometrial canal measures 4.2 cm in length and 2.0 cm in greatest width. The endometrium measures 0.1 cm in thickness and has a tan, smooth and glistening appearance. The myometrium measures 1.5 cm in thickness and is unremarkable. Representative sections are submitted as follows: E1 - additional section right ureter, E2 additional section left ureter, E3 posterior bladder wall with right ureter orifice and small portion of possible mass, E4-e7 right bladder wall with mass with extension beyond bladder wall with soft tissue margin, E8 anterior bladder wall, E9 left bladder wall with mass near ureter, E10-E12 left bladder wall with mass and soft tissue margin, E13 left trigone region with mass, B14 left trigone region with mass and portion of vaginal mucosa, E15 right trigone region with mass, E16 anterior bladder wall, E17-E18 posterior bladder wall with mass, E19-e20 anterior cervix, E21 posterior cervix, E22 anterior uterine. wall, E23 posterior uterine wall.. -. ! F. Received fresh at the frozen desk labeled "urethral margin #2" are two fragments of red-pink soft tissue measuring 1.1 x 0.6 x 0.5 cm. The. specimen is totally submitted for frozen section in one cassette labeled F1. G. Received in formalin labeled "right pelvic lymph nodes" are multiple yellow-tan segments of nodular adipose tissue aggregating to 5.8 x 4.3 x 1.7 cm. Palpation reveals three tan, firm nodules resembling lymph nodes ranging in size from 1.2 to 1.8 cm in greatest dimension. Additionally a fragmented matted segment of nodular tissue is present measuring 4.4 x 4.0 Page 4 of 5
+
+--- Page 5 ---
+Encounter Date: cm. The nodules are totally submitted as follows: G1 two nodules, G2 one nodule bisected, totally submitted, G3-g7 fragmented matted segment totally submitted. H. Received in formalin labeled "left pelvic lymph nodes" are multiple yellow-tan segments of nodular adipose tissue aggregating to 7 x 5 x 1.5. cm. Palpation reveals 14 tan, firm nodules resembling lymph nodes ranging in size from 0.2 to 2.4 cm in greatest dimension. Additionally one fragmented matted segment is also received in the same container measuring. 5.5 x 2.0 cm. The nodules are totally submitted as follows: H1 four nodules, H2 four nodules, H3 four nodules, H4 one nodule, H5 one nodule, H6-Hio fxagmented matted segment sectioned and totally submitted. Patient ID #: DOB: lAge: Date of Report: Date of Procedure: Date of Receipt: Submitted by: Additional Physician(e): Location: Test performed by: Lab and Collection SURGICAL PATHOLOGY (Order: on!  Lab and Collection Information Result History SURGICAL PATHOLOGY (Order Order Result History Report. Result Information  Result Date and Time Status Provider Status Final result Reviewed MyChart Status: : This result is currently not released to Display Full Result Report Display Order Report Page 5 of 5
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diff --git a/output/text/6e6a9987-cd3e-4d05-aced-2d9cbd4ef3b8.txt b/output/text/6e6a9987-cd3e-4d05-aced-2d9cbd4ef3b8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2f06987f0dd53ddf0200ecaaf0f47f65282a33c5
--- /dev/null
+++ b/output/text/6e6a9987-cd3e-4d05-aced-2d9cbd4ef3b8.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis: 1. and 2.: Right-sided hemicolectomy preparation with tumor-free oral and aboral resection. margins which also includes an ulcerated, moderately differentiated adenocarcinoma of the cecum with invasion of all parietal layers, penetration of the peritoneum, multiple regional 1ymph node metastases and peritoneal seeding. (G2, pT4 pN2 L1, V0, pN2 12/35 pM1
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diff --git a/output/text/6ea821f4-a6f9-4d7d-8a89-da947da69a47.txt b/output/text/6ea821f4-a6f9-4d7d-8a89-da947da69a47.txt
new file mode 100644
index 0000000000000000000000000000000000000000..158739aef708c029df0c375d48729be0980223ad
--- /dev/null
+++ b/output/text/6ea821f4-a6f9-4d7d-8a89-da947da69a47.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis/ diagnoses: 1. Right hemicolectomy preparation with an ulcerated colon carcinoma of the histological type of a moderately differentiated colorectal adenocarcinoma, situated in the passage between the cecum and the ascending colon and measuring 6 cm in. diameter at the widest point. Invasive spreading of the tumor within all intestinal wall layers to the bordering fatty tissue. The cecum has a tubulovillous adenoma of. the mucous membrane with moderate epithelial dysplasia. The resection margins. and greater omentum are tumor-free. Two of ten lymph nodes with metastases of. the colon transversum. 2. Subcapsular liver parenchyma section with a complete cirrhotic remodeling and. pronounced fatty degeneration of the parenchyma (fatty liver cirrhosis). Tumor stage of is therefore: pT3 pN1 (2/10) L0 V0; G2 Follow-up report: As reported, a further lymph node preparation was carried out following acetone fixation. This revealed 31 lymph nodes ranging predominantly from very small to 0.7 cm in diameter. All lymph nodes in the histological examination were tumor-free. Therefore a final lymph node status of pN1 (2/41) is established.
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diff --git a/output/text/6ecc7cd4-fa5c-47e3-90a7-2ca140366a3a.txt b/output/text/6ecc7cd4-fa5c-47e3-90a7-2ca140366a3a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..69d7c6f162d95336166fd59a2e9254f79567800d
--- /dev/null
+++ b/output/text/6ecc7cd4-fa5c-47e3-90a7-2ca140366a3a.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+IcD O -3 UUID:AD89F764-5C47-4155-A062-CE97CBB81E39 sercinona, renal ceel RedE tec Chomsphsbe type 8317|3 Sute DXicney NoS Cb4.9 Surgical Pathology Report hO9/24|13 Diagnosis: Kidney, left, laparoscopic nephrectomy - Renal cell carcinoma, chromophobe type, grade 3 (of 4, Fuhrman classification), 11 cm diameter, without angiolymphatic invasion, without extracapsular extension, inked surgical margins not involved Clinical History: The patient is a  year-old male with a left renal mass who now undergoes hand-assisted laparoscopic left nephrectomy. Gross Description: Received is one appropriately labeled container. Specimen A is received in a container additionally labeled "left kidney".. Specimen fixation: formalin Type of specimen: radical nephrectomy, laparoscopic Side of specimen: left Size and weight of specimen: size = 15 x 10.5 x 7.8 cm; weight = 900 gm Presence/absence of adrenal gland: adrenal gland is absent. Tumor description/site: The tumor involves both upper and lower poles of the kidneys; the kidney also involves the cortex and medulla and appears to compress the renal pelvis; the tumor is tan in color; tumor is solid with small amounts of hemorrhage present; the center of the tumor appears necrotic. Tumor size: 11 x 9 x 7.5 cm Presence/absence of multicentricity: absent; there is only one focus of tumor. Confinement/non-confinement to the kidney: The tumor is confined to the kidney; this is supported by the fact that the tumor capsule is freely mobile and is slipping away from the bivalved surface.. Extent of invasion: Perirenal adipose tissue: tumor does not grossly involve Gerota' s fascia: tumor does not grossly involve
+
+--- Page 2 ---
+Renal vein: tumor does not grossly involve Ureter: tumor does not grossly involve Other organs: no other organs present Surgical margins: Perirenal adipose tissue: negative Renal vein: negative. Renal artery: negative Ureter: negative. Description of kidney away from tumor: The renal parenchyma in the lower pole of the kidney appears slightly hemorrhagic and congested without a distinct corticomedullary junction; the remaining renal parenchyma in the upper pole of the kidney appears more normal with a definable corticomedullary. junction. There is no evidence of cysts of hydronephrosis present.. Lymph nodes (hilar): none are identifiable Other significant findings: Tissue submitted for special investigations: none Digital photograph taken:. Block Summary: A1 - ureteral, arterial and venous margin A2 - tumor in relation to capsule. A3-A4 - representative sections of tumor, capsule, and normal renal parenchyma. A5-A10 - representative sections of tumor A11 - normal renal parenchyma Grossing Pathologist: , M.D.. Light Microscopy: Light microscopic examination is performed by Dr.. Histologic tumor type/subtype: renal cell carcinoma, chromophobe subtype.. CD117 foc pos, CD10 foc pos Dr. concurs. Histologic grade (if applicable): 3 Tumor size (greatest dimension): 11 cm Extent of tumor invasion:. Capsular invasion/perirenal adipose tissue: no Gerota' s fascia: not identified
+
+--- Page 3 ---
+Renal vein: not involved Ureter: not involved Venous (large vessel): not identified Lymphatic (small vessel): not identified Depth of invasion: n/a Adjacent organs: not identified Histologic assessment of surgical margins: Perirenal adipose tissue: negative Gerota' s fascia: negative Renal vein: negative Renal artery: negative Ureter: negative Adrenal gland: not received Lymph nodes: not received Other significant findings: none AJCC Staging: pT2 pNx pMx 8/31//3
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diff --git a/output/text/6edb3687-cb11-441b-96dc-e752d3f2b3c8.txt b/output/text/6edb3687-cb11-441b-96dc-e752d3f2b3c8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..47a49d0779a86d4a3864b2337019f2bbb379f069
--- /dev/null
+++ b/output/text/6edb3687-cb11-441b-96dc-e752d3f2b3c8.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+TSS ID: TSs iD: Oc ID: Date of Procurement: Gross Description: Breast with the tumor of 3.5 x3.3 cm in size, with extension under the skin. All ten examined lymph nodes demonstrate metastases. Microscopic Description: Infiltrating duct and lobular carcinoma; G2. Skin is involved. All ten examined lymph nodes demonstrate metastases. Diagnosis Details: Tumor Features: Unknown, Tumor Extent: T4 Chest wall or (and) skin involved, Venous Invasion: Absent, Margins: Absent, Treatment Effect: Comments: /es-0-3 Postoperative staging reads as folloes: T4c N3a MO. Carcnon+, nifiItutrg dvct ard lobulw 853sf3 Formatted Path Report: Sifs, bsust,Nos c5s.9 4/g/n h BREAST TISSUE CHECKLIST Specimen type: Radical mastectomy Specimen size: Not specified. Tumor site: Breast Tumor size: 3.3 x 0 x 3.5 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal and lobular carcinoma Histologic grade: Moderately differentiated. Tumor extent: Skin  Lymph nodes: 10/10 positive for metastasis (Axillary 10/10) UUID:D10A419F-B161-4998-97DE-45DF70F4E2120 TCGA-E9-A1RC-01A-PR Redacted Extracapsular invasion of the lymph nodes: Not specified Margins: Not specified Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified
+
+--- Page 2 ---
+TSS ID Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified. Comments: None Laterality: Right, upper outer quadrant.
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diff --git a/output/text/6f1b1fb4-1b8e-4634-8744-7147134c09cf.txt b/output/text/6f1b1fb4-1b8e-4634-8744-7147134c09cf.txt
new file mode 100644
index 0000000000000000000000000000000000000000..12508518970c191c989c37c0d34b69f6001abdb3
--- /dev/null
+++ b/output/text/6f1b1fb4-1b8e-4634-8744-7147134c09cf.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+TCGA-AK-3427 SURGICAL PATHOLOGY REPORT Copy To: Clinical History/Diagnosis: ? Renal Cell CA vs. TCC. Left Renal Mass Source of Specimen(s): A: Left kidney, para aortic lymph nodes and left adrenal gland. B: Additional para aortic lymph nodes. C: Left common iliac lymph nodes. Gross Description: Received in three parts. Source of Tissue: 1. Labeled #1, left kidney, para aortic lymph nodes, left adrenal gland Frozen Section Diagnosis: 1FS- ONCOCYTOMA PER. Gross Description: Received fresh is a left kidney with attached perinephric fat weighing 580 grams with an overall measurement of 20 x 13 x 9 cm. In the superior aspect of the perinephric fat is the adrenal gland measuring 3 x 2.5 x 1.3 cm and it is grossly normal appearing. No Iymph nodes are found in the attached fat. At the hilum, there is a 10.5 x 0.5 cm segment of ureter which is opened and is normal appearing. The. vascular margins are free of any lesions or masses. The specimen is bivalved and the kidney itself measures 12.5 x 7.5 x 4.7 cm. In the lower pole of the kidney there is a large round tumor measuring 6.5 x 5.0 x 4.0 cm. The lesion pushes on the capsule and grossly approaches the inferior and middle. However, no gross invasion is found. Representative sections of the tumor are submitted for frozen section consultation in 1FS. The second lesion is found in the mid lateral aspect of the kidney and measures 1.4 x 1.4 x 1.2 cm and is orangish-brown in color and soft. This lesion is 2 cm from the above mentioned mass. Further sectioning through the superior pole discloses an ill-defined circumscribed potential lesion that measures 0.8 x 0.8 cm and may represent a third tumor. The superior pole lesion is 5.6 cm from the inferior pole mass. Designation of Sections: 1A- ureter margin, 1B- vascular margin, 1C- adrenal gland, 1D- large mass in relationship to hilum, 1E- large mass in relationship to normal appearing parenchyma, 1F- tumor in relationship to. capsule and fat, 1G-1H- smaller tumor in middle of kidney, 1I-1J- smaller potential lesion superior left kidney, 1K-1L- uninvolved kidney, 1M-1N- perinephric fat Summary of Sections: 1A-1N.
+
+--- Page 2 ---
+Tissue is procured for cytogenetic studies. ********************************************************************x*** Source of Tissue: 2. Labeled #2, additional para aortic lymph nodes. Gross Description: Received fresh are five fatty lymph nodes measuring from 1 up to 3 cm. Designation of Sections: 2A-2B- four single lymph nodes, 2C- single bisected node. Summary of Sections: *********** ***************************x******** Source of Tissue: 3. Labeled #3, left common iliac lymph nodes Gross Description: Received fresh are three yellow to red firm lymph nodes measuring respectively 1 x 0.8 x 0.8, 1.2 x 0.9 x 0.8 and 1.4 x 0.9 x 0.9 cm. Submitted as is in 3A. Designation of Sections: 3A Summary of Sections: *********************************************************************** Final Diagnosis: 1. Left kidney, adrenal gland and para aortic lymph nodes; radical. nephrectomy: - Three tumors confined to the kidney. - Two oncocytomas located at the Iower pole (6.5 cm) and upper pole (0.8 cm). - One chromophobe renal cell carcinoma located in the middle portion (1.4 cm). - Ureteral and vascular resection margins and one lymph node are all negative for tumor (0/1). - Adrenal gland is negative for tumor, see note. 2. Additional para aortic lymph nodes: - No tumor seen in all ten lymph nodes (0/10) 3. Left common iliac Iymph nodes: - No tumor seen in all four lymph nodes (0/4). Note: On immunohistochemical stains the oncocytoma tumor cells are. positive for CD10 (cytoplasmic) and E-cadherin (variable and weak. membranous staining) and are negative for vimentin and cytokeratin CK7. The chromophobe renal cell carcinoma tumor cells are positive for cytokeratin CK7 and E-cadherin (strong membranous), and are negative for
+
+--- Page 3 ---
+vimentin and CD10. This case was presented at our intradepartmental conference on with agreement in diagnosis. See cytogenetics report. These tests were developed and their performance characteristics determined by the immunohistochemistry laboratory at the r. These tests have not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance ot approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement (CLIA) as qualified to perform high complexity clinical testing. Procedures/Addenda FC Cytogenetics Tumor Results-Comments CYTOGENETIC ANALYSIS REPORTS KARYOTYPE: Abnormal mosaic karyotype: 44,X,-Y,-1,+7,-14,+20,-21[8]/46,XY[12] RESULTS: The renal mass was sent to a commercial laboratory for cytogenetic analysis. The chromosomes from the cells of nine- and ten-day adherent cultures were counted and analyzed, and two of these metaphases were karyotyped by G- banding. Eight cells had a modal chromosome number of 44 and were characterized by the loss of chromosomes Y, 1, 14, and 21 and gain of. chromosomes 7 and 20. Twelve cells had a modal chromosome number of 46 and appeared to have a normal karyotype. Cytogenetic abnormalities involving the numerical loss of chromosomes Y and 1, often without additional changes, have been reported in renal oncocytomas.
\ No newline at end of file
diff --git a/output/text/6f2217de-3c7d-4404-b8d2-6d7e694e979d.txt b/output/text/6f2217de-3c7d-4404-b8d2-6d7e694e979d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9880509a67f8df55fec7b04b8ff0c6f71d5d34fa
--- /dev/null
+++ b/output/text/6f2217de-3c7d-4404-b8d2-6d7e694e979d.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+*** Diagnosis / Diagnoses: *** 24-cm-long resection of the colon under inclusion of a poorly differentiated, largely ulcerated adenocarcinoma, of a maximum of 3.5 cm in diameter and of the colorectal type, with infiltration of the pericolic fatty tissue (pT3; G3). Tumor-free resection margins of the colon. Three tubular adenomas in the colonic mucosa with low- to moderate-grade dysplasia in the remainder. A follow-up report will be made on the lymph node status. Follow-up report: A total of 28 histologically tumor-free lymph nodes of a maximum of 0.8 cm in diameter were determined after acetone fixation. Final tumor stage: pT3 pN0 (0/28) pMX; G3
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diff --git a/output/text/6f2d2100-a2fa-429a-84a0-4481eaff26a2.txt b/output/text/6f2d2100-a2fa-429a-84a0-4481eaff26a2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6845d8305292e07fb9ebf16d09c5429ad188937f
--- /dev/null
+++ b/output/text/6f2d2100-a2fa-429a-84a0-4481eaff26a2.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+FINAL DIAGNOSIS: Part 1: .Breast, right, segmental mastectomy, needle LOcalization - A. INVASIVE QUCTAL CARCINQMA. NOTTINGHAm GRADE 3 (TUBULE FORMATION 3, NUCLEAR POLYMORPHISM 3, MITOTIC ACTIVITY 3, TOTAL SCORE 9/9). B. InVASIVE TUmOR MEASURES 2.1 CM In GREATEST DImEnSION (GROSS MEASUrEmEnT). C. DUCTAL CARCInOMA IN SITU (DCIS), SOLID PATTERN, NUCLEAR GRADE 3, ADMIXED WITH InVASIVE CArcInOmA, COnstiTuting AbOut fivE PERCEnt (5%) Of tOtal tumOR VOlumE. D. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA; INVASIVE CARCINOMA IS 1.5 MM TO THE CLOSEST ANTERIOR MARGIN E. NO DEFINITIVE LYMPHOVASCULAR INVASION NOTED. F. FOCI OF MICROCALCIFICATIONS ASSOCIATED WITH INVASIVE CARCINOMA. G. FIBROCYSTIC CHANGE. H. THE INVASIVE CARCINOmA IS ER POSITiVE, PR POSITIVE, HER2/NEU WEAKLY POSITIVE AND NO AMPLIFICATION BY FISH ANALYSIS IcD-0-3 PaRt 2: AXIlLA #1 SEnTineL Lymph nODe, Right, biOpSy  Carcmona vifiltruftg ductal. nos 85oc/3 ONE Lymph nODE, nEGATIVE fOR metaStaTIC CARCinOMA. St:6rsst,Nos c50.9 3131 h LATERALITY: Right PROCEDURE: Segmental LOCATION: Not specified SIZE OF TUMOR:  Maximum dimension invasive component: 2.1 cm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: No TUMOR TYPE (invasive component): Ductal adenocarcinoma, NOS NOTTINGHAM SCORE: Nuclear grade: 3 Tubule formation: 3 Mitotic activity score: 3 Total Nottingham score: 9. Nottingham grade (1, 2, 3): 3 ANGIOLYMPHATIC INVASION: No DERMAL LYMPHATIC INVASION:  Not applicable CALCIFICATION: Yes, malignant zones TumOr TYpe, In SitU: Solid SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No Distance of invasive tumor to closest margin: 1.5 mm SURG MARGINS INVOLVED BY IN SITU COMPONENT: No Lymph NODeS EXAMIneD: 1 METHOD(S) OF LYMPH NODE EXAMINATION: H/E stain SENTiNEL NODE METASTASIS: No NON-NEOPLASTIC BREAST TISSUE: FCD t stage, pathologic: pT2 N Stage, pathologic: pN0 m Stage, PathOlOgiC: pMX ESTROGEN RECEPTORS: positive PROGESTERONE RECEPTORS: positive UUID: 584E15EE-1C80-4507-8AD3-558DF06DBDF3 TCGA-BH-A0H9-01A-PR Redacted HER2/NEU: 2+ Xt377t
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diff --git a/output/text/6f362890-da81-432d-8e9b-d80a084e88ad.txt b/output/text/6f362890-da81-432d-8e9b-d80a084e88ad.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ff02c1599da88acc67530ca666b46defddc9d688
--- /dev/null
+++ b/output/text/6f362890-da81-432d-8e9b-d80a084e88ad.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SUPPLEMENTAL REPORT DIAGNOSIS: TOTAL LARYNGECTOMY: SQUAMOUS CARCINOMA INVADING THYROID CARTILAGE. DIAGNOSIS (A) TOTAL LARYNGECTOMYBILATERAL NODE DISSECTION II,III,AND IV AND LEFT THYROIDECTOMY: SQUAMOUS CARCINOMA GRADE 2 INVOLVING LEFT PYRIFORM SINUS, LEFT ARYEPIGLOTTIC FOLD AND PROBABLY THYROID CARTILAGE. PRESENCE OF PERINEURAL AND LYMPHOVASCULAR INVASION. Margins of resection free of tumor. Thyroid gland, no tumor. METASTATIC SQUAMOUS CARCINOMA IN 7 OF 25 LEFT LYMPH NODES PRESENCE OF EXTRANODAL EXTENSION (4 OF 1O LEVEL II, 3 OF 5 LEVEL III, O OF 7 LEVEL IV) RIGHT NECK LYMPH NODES: Thirteen lymph nodes, no tumor (0/5 in level II, 0/6 in level III, 0/2 in level iv). (B) LEFT BASE OF TONGUE: Squamous mucosa, no tumor. (C) LEFT PHARYNGEAL WALL: Squamous mucosa, no tumor. COMMENT Bone and cartilage were sent for decalcification from the larynx. Supplemental report will follow. A tracheostomy was present. Page 1 of 2 History Case Pathology Report History Case Pathology. File under: Pathology
+
+--- Page 2 ---
+GROSS DESCRIPTION (A) TOTAL LARYNGECTOMY, BILATERAL LEVEL II, III, IV LYMPH NODE DISSECTION AND LEFt THyroiDectoMy - A total laryngectomy with attached bilateral neck lymph node dissection measures 11.0 x 11.0 x 5.0 cm in toto. The attached left lobe of thyroid is measuring 3.0 x 2.0 x 1.5 cm. A tracheostomy is also present. An ill-defined tan firm mass measuring 5.0 x 2.0 cm to the depth of 2.0 cm is present at left pyriform sinus with extension to left epiglottic fold. The tumor invades into thyroid cartilage. The tumor is 0.4 cm from the. closest left pharyngeal mucosa (additional margin from this side has been additionally submitted (part C. The base of tongue is also submitted. separatelypart B)The right pharyngeal mucosa is 1.0 cm from the tumor. The thyroid, Taryngeal mucosa,hyoid bone and thyroid are free of tumor. A portion of the tumor and normal mucosa have been obtained for additional studies. SEctIoN coDe: A1-A7,lateral aspect of the tumor sectioned from superior to inferior;A8left soft tissue margin en faceA9aryepiglottic foldA10, medial (right side) pharyngeal mucosa margin perpendicular (margin is inked in blueAl1-Al8,medial aspect of thetumor. Sectione from superior to inferior A19tumor invading thyroid bone pending decalcification A20,left voca1cordA21right voca1 cordA22 tracheal margin; A23, tracheostomy; A24thyroid glandA25-A29 1eftleve1 II 1ymph nodes A25 six 1ymph nodes, A26,three1ymph nodes,A27 two positive 1ymph nodes,A28 one positive 1ymph node, A29 one positive 1ymph node (the largest positive lymph node measures 1.5 cm in the greatest dimension) A30, three left level IIr lymph nodes; A31 two positive left level IIr lymph nodes; A32, four left level Iv' 1ymph nodes; A33, three leve7_IV 1ymph nodes; A34, two right level II 1ymph nodes; A35, three right level II 1ymph nodes; A36, four right level IIi 1ymph nodes; A37 two right level_III lymph nodes: A38, one right left Iv lymph node; A39, one right Tevel Iv lymph node.. B)LEFT BAsE_OF TONGUE-One piece of mucosa3 x 0.5 x 0.3 cm. Entirely submitted for frozen section diagnosis in B. *FS/DX:SQUAMOUS MUCOSANOTUMOR PRESE (C) LEFT PHARYNGEAL WALL - One piece of mucosa measuring 7 x 3 x 0.2 cm with attached hemostat which is designated as up end. The up end is inked in blue, and the low end is inked in green SECTION CODE: c1, up half of the specimen; c2, lower half of the specimen. *FS/DX: SQUAMOUS MUCOSA,NO TUMOR PRESENT. SNOMED CODES M-80703T-24100 Page 2 of 2 History Case Pathology Report History  Case Pathology. File under: Pathology.
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diff --git a/output/text/6fa0b644-b009-401d-ae8d-09f4a0b8f876.txt b/output/text/6fa0b644-b009-401d-ae8d-09f4a0b8f876.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f952154b49d514352165ce195603994a013889e1
--- /dev/null
+++ b/output/text/6fa0b644-b009-401d-ae8d-09f4a0b8f876.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Casinoma,mfi1trating ductol, N0s 85ov/3 UUID:E2E6CA23-AFE4-488F-90AC-32639687A590 TCGA-A2-A1G1-01A-PR Redacted Sit: yreeot,Nos c5Q.q. 1f25/n hsr- surgical report Name. Sex: F Pathology Numbe! DOB Date Collected: 1 Locatlon: Date Received: Doctor: M.R. Number Account Numbe Pre-Operative DiagnOsisd Right sreast CA. pOst-Operative DiaGnosis RiGHT SREAST CA Procedure Right BReAst LUmpeCTOmy with Sentinel. Lymph nODe BIOpSy. F.S.: POssiBLe AXiLLAry DissectIOn Tissues A. BREAST EXCiSiON,NEEDLE LOC,SIMPLE,MARGINS,ETC. - RiGHT BREAST LUMP 8. SENTINEL LYMPH NODE (S) -#1 **FS** Fs Diagnosis A. Right breast Lump (grOss margins) --  MArGInS grOSSLy NEgATIVe fOR MALIgnAnCy. B. Right sentinel Lymph node #1, f.s. - Sentinel node #1, negative for malignancy. (reporteD to surgeon: Dlagnosed by: FINAL DIAgNOSiS A. Right Breast Lump  POorly DiFferentiated inriltrating Ductal Carcinoma wIth central NecROsis (ScarFf-sLOOm-RicharDsOn grADe iN/IH). The TumOr mEAsUres 3 Cm. in mAXimUm DimeNs!ON. LymPHoVASCULAR InVAsiOn iDenTIFIeD insiDe THe TumOR. All surgical margins are free of the tumor. B. Right sentinel Lymph node #1 - One positive lymph node (1/1). Ptnm ClAssiFicaTiOn: Stage ib, t2 n1 mx. pQrI category iI: 3260F Diegn osed by: Revlawed and slectronicalty signed out by: Patlent Nama Pathology Number: SURgiCAL REPORT Page 1 of 2
+
+--- Page 2 ---
+Patlent Nam Pathology Number: COmmEnT Specimen *B" shows metastatic carcinorna which is shown in the permanent section and not In the frozen section.. This case is dlscussed with Dr. gROsS DEsCRiPTION The speclmen is received in two separate containers labeled designated A and B. A The container !s recelved fresh unfixed labeled "right breast lump" and consists of a 33 gm. ovoid mass of apparent fatty and fibrous-encased tissue which is 5.5 x 4.5 x 2 crm. In greatest overal dimenslon. There are two sutures indlcating superlor margin Inked with yellow dye, inferlor Is Inked green. There Is a single short suture indicating laterai margin inked with orange dye.. mediai is inked biack. There is a single short suture indicating anterior margin inked with blue dye, posterior Is Inked red. Sectioning reveals a tumor which is 3 x 2.5 x 1 cm. in greatest overall dimenslon and grossly appears to be 0.4 cm. from the superiox/yeilow, 0.9 cm. from the inferior/green, 0.4 cm. from the medial/blaok, 0.3 cm. from the lateral/orange, 0.5 cm. from the. anterior/blue, O.6 cm. frorn the posterior/red. The specirnen is submitted In twelve blocks.. Key Note Block Summary. 1--superior, 2--inferior, 3--mediai, 4 --lateral, 5-- anterior, 6--- posterior, 7 through 9.- tumor, 10 through 12---random. B. The container Is received fresh unfixed labeled *right sentinel iymph node #1 for frozen section" and consists of an ovoid mass of apparent fat which is 1.5 x 1 x 0.6 cm. in greatest overall dimenslon. Sectloning reveals a 1 cm. pink-tan frm nodule. Touch prep and frozen section are obtained by Dr. The entire specimen including frozen section is submitted in two blocks. MiCROsCOPiC eXAm MCROSCOPiC ExAminAtiOn CONDUcteD By PAThOLOgist COnFIRmS FinAL DiAGNOSI8. XSQLAIFIED Patlent Narr Pathology Number: SURGICAL REPORT Page 2 of 2
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diff --git a/output/text/6fbe07f8-0589-4509-aa7a-fe905882cccd.txt b/output/text/6fbe07f8-0589-4509-aa7a-fe905882cccd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fefaca77a365c08fabf5c28ce83713051d2b383f
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Date Coll: SURGICAL PATHOLOGY REPORT SPECIMEN A. Subtotal colectomy B. Appendix CLINICAL NOTES PRE-OP DIAGNOSIS:  Carcinoma splenic flexure POST-OP DIAGNOSIS: Same, hepatic flexure to sigmoid-descending colon junction. GROSS DESCRIPTION A.  Received fresh labeled "subtotal colectomy" is a previously unopened and unoriented 35 cm. segment of colon surfaced by smooth to slightly scabrous tan-pink serosa with a copious amount of attached mesocolon and omentum. A palpable area of induration is noted.  The omentum overlying the area is focally retracted and subsequently inked orange. The pre-serosal surface in the vicinity of the palpable mass is inked black.. The undesignated margins measure 6.0 and 6.5 cm.  Upon opening, there is a circumferent: ial 10.5 x 9.5 cm. focally necrotic glistening tan-pink tumor mass which is 9 cm. from the larger margin. On sectioning, the tumor has a maximal thickness of 2.4 cm. grossly extending through the muscularis to within 0.15 cm. of the inked pre-serosal surface (block 4) and adherent omentum (see blocks #2 and 3). A portion of tumor and a portion of normal mucosa are submitted for tissue procurement as requested. A pedunculated 1.2 x 0.8 x 0.6 cm. tan pink-red polyp is present within 2 cm. of the margin of the tumor mass (between the tumor mass and the larger circumference margin).  The remaining mucosa  unremarkable glistening tan-pink with regular folds and the wall averages 0.7 cm. A single shallow diverticulum is also identified.  Several soft to slightly rubbery mucoid-appearing tan-white tissues in keeping with lymph nodes measuring up to 1.3 cm. in greatest dimension are recovered from the attached mesocolon. Representative sections are submitted in fifteen (15) blocks as labeled:` BLOck suMMARy: #1 - Undesignated margins (smaller circumference margin inked blue larger, circumference margin closest to tumor inked green); 2,3  tumor to inked indurated omentum; 4 - tumor to inked free radial serosal surface; 5 central tumor; - tumor to normal mucosa; 7,8 - bisected polyp (1/2 per cassette); 9,10 - random from remainder of specimen; 11 - eight (8) whole lymph nodes; 12,13 - seven (7) whole lymph nodes per cassette; 14 six (6) whole lymph nodes; 15 - one (1) bisected lymph node.
+
+--- Page 2 ---
+B. Received in formalin labeled "appendix" is a 5.0 x 0.7 cm. gross unremarkable appendix.  The specimen is sectioned to show an intact wall. discrete gross lesions are identified. Representative sections of the specimen are submitted in one cassette with the proximal end inked blue. RS-1. MICROSCOPIC DESCRIPTION Histologic type:. Mucinous adenocarcinoma. Histologic grade: Moderately differentiated.. Primary tumor (pT):. Tumor invades completely through the wall of the colon into the omental fat (pT4b).. Proximal margin:.  Negative. Distal margin: Negative. Circumferential (radial) margin: Negative. Vascular invasion: Negative. Regional lymph nodes (pN): 2 of 30 mesenteric lymph nodes contain metastatic mucinous adenocarcinoma (pN1b). Non-lymph node pericolonic tumor:. Absent. Distant metastasis (pM): pMx Other findings: Adenomatous polyp..  Appendix with appendiceal lymph node without significant histopatholgic findings. 5, 1 N DIAGNOSIS A. Colon, subtotal colectomy: Invasive moderately differentiated mucinous adenocarcinoma extending through the wall of the colon into the omental fat. Proximal, distal and radial margins of resection are free of tumor. Two of 30 mesenteric lymph nodes contain metastatic mucinous adenocarcinoma (2/30). Adenomatous polyp. B. Appendix, appendectomy: No significant histopathologic findings.. Periappendiceal lymph node without significant pathologic findings. - End Of Report
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diff --git a/output/text/6fe3d3bb-e0ba-4061-b11a-186096aea4fd.txt b/output/text/6fe3d3bb-e0ba-4061-b11a-186096aea4fd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..81f0de994291439ce26af08ec4ddbd091799de7d
--- /dev/null
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+
+--- Page 1 ---
+UUID:BA049E0E-E848-415B-ACBD-B615FCA71BE9 TCGA-IA-A40U-01A-PR Redacted Results SURGICAL Patient Info Patient Name Sex DOB Results Specimen #: Submitting FINAL DIAGNOSISS 1. Left kidney, radical nephrectomy (A) - Renal cell carcinoma, papillary type (8.5 cm in greatest dimension). Fuhrman nuclear grade 3 of 4. (See comment) - The tumor grossly extends into the renal vein and renal sinus fat. - The renal vein margin of resection is positive for tumor. - The ureteral, arterial and soft tissue margins of resection are negative for tumor.. - The adrenal gland is negative for tumor. 2. Retro-aortic vein, biopsy (B) - Renal cell carcinoma, papillary type, invading vein wall. 3. Renal vein wall, margin, biopsy (c) - Muscular wall negative for tumor. (See comment). 4. Ivc thrombus, excision (D) - Renal cell carcinoma, papillary type, invading vein wall. 5. Para-caval lymph nodes, excision (E) - Seven lymph nodes, negative for neoplasm (0/7). - Focal non-necrotizing granulomas. (See comment).  COMMENT A. Procedure: Radical nephrectomy (with adrenal gland) Specimen Laterality: Left icp-o-3 Tumor Site: Upper-mid pole Tumor Size: 8.5 x 6.5 x 6.5 cm 82<0j3 Tumor Focality: Unifocal Macroscopic Extent of Tumor:  Tumor extension into renal sinus. 83'12 - Tumor extension into major veins (renal vein or its segmental (muscle containing) branches, inferior vena cava) Histologic Type: Papillary renal cell carcinoma. Sarcomatoid Features: Not identified. Tumor Necrosis: Present Histologic Grade (Fuhrman Nuclear Grade): 3/4. Microscopic Tumor Extension: (select all that apply) Tumor extension into renal sinus. - Tumor extension into major vein (renal vein or its segmental (muscle containing) branches, inferior vena cava) Page 1 of 3
+
+--- Page 2 ---
+Eneounter Date: Margins: Margin(s) involved by invasive carcinoma . Renal vein margin. Lymphovascular Invasion: Not identified Pathologic Findings in Nonneoplastic Kidney: Patchy subcortical chronic inflammation and focal glomerulosclerosis Pathologic Staging (pTNM): pT3b N0 MX Number lymph node examined: 7 Number lymph node positive: 0 C. The vein wall margin of resection is negative for tumor. A detached fragment of papillary renal cell carcinoma is present in the slides, but is not adherent to the wall.. E. A systemic granulomatous process, such as sarcoidosis, should be excluded clinically. (Electronic Signature) SPECIMEN SUBMITTED A: LEFT KIDNEY B: RETRO-AORTIC VEIN C: WALL MARGIN D: THROMBUS E: PARA-CAVAL LYMPH NODES CLINICAL DATA LEFT RENAL MASS AND IVC THROMBUS GROSS DESCRIPTION A.  Received in formalin labeled "left kidney" is a specimen consisting of a left kidney surrounded by an envelope of fibroadipose tissue measuring 20.5 x 9.6 x 7.0 cm and weighing 740 grams. The kidney measures 13.5 x 6.8 x 5.0 cm. The kidney demonstrates an 8.5 x 6.5 x 6.5 cm tan soft and friable mass in the.upper and mid poles of the kidney. Extensive necrosis is identified. Focal hemorrhage is seen. The mass grossly involves the renal sinus fat. The overlying renal pelvis is unremarkable. The mass bulges the renal capsule however does not extend into the surrounding fibroadipose tissue. It is adjacent to the inked soft tissue line of resection. The tumor is sharply demarcated from the renal parenchyma which appears tan-white and pale. Satellite nodules of tumor are not present. Sectioning of the renal veins, particularly those draining the area of the mass does show the intravascular presence of neoplasm. The mass grossly involves the renal vein margin. An adrenal gland is present measuring 5.8 x 2.6 x 1.0 cm and is not involved by tumor. The adrenal cortex is yellow-orange and unremarkable. A 5 cm segment of ureter is present and is essentially unremarkable. Lymph nodes are not seen. Representative sections are submitted as follows: Al ureter margin; A2 artery margin; A3 renal vein margin with mass; A4 - A5 mass with renal sinus and renal pelvis; A6 - A7 mass with soft tissue line of resection; A8 - A10 mass; Al1 uninvolved kidney; A12 adrenal. B. Received in formalin labeled "retroaortic vein" is a segment of vascular tissue measuring 3.5 cm in length and 0.9 cm in diameter.  The lumen is occluded by tan soft and friable tissue. The tissue extends to Page 2 of 3
+
+--- Page 3 ---
+Eneounter Date within O.5 cm of one margin and is at the opposite margin. Focal hemorrhage and necrosis is identified. The tissue is firmly adhered to the interior vascular walls. Representative sections are submitted as follows: B1 involved margin; B2 opposite margin; B3 representative section. C. Received in formalin labeled "wall margin" are three segments of. tan-gray vascular wall aggregating to 1.6 x 1.4 x 0.5 cm. The wall appears unremarkable. The specimen is totally submitted in formalin in C1. D. Received in formalin labeled "thrombus" are multiple fragments of tan-brown soft and friable tissue aggregating to 5 x 5 x 2.6 cm. A segment of vascular tissue is identified measuring 4.3 cm in length and 2.8 cm in diameter. The lumen is occluded by tan soft and friable tissue. The tissue demonstrates focal hemorrhage and necrosis. Representative sections are submitted in formalin in Dl - D3.. E.  Received in formalin labeled "paracaval lymph nodes" are multiple fragments of yellow-brown fibroadipose tissue aggregating to 4.3 x 3.8 x 1.7 cm. Sectioning reveals multiple ovoid tan firm nodules resembling lymph nodes ranging in size from 0.4 to 1.7 cm. The nodules are submitted as follows: E1 four nodules; E2 three nodules; E3 two nodules. Patient ID #: DOB: (Age: Report: Date of Procedur Date of Receipt: Submitted by: Location: Test performea by: Lab and Collection SURGICAL PATHOLOGY (Order Jon.  - Lab and Collection Information Result History SURGICAL PATHOLOGY (Order on  Order Result History Report. Resuit Information Result Date and Time Status Provider Status Final result Reviewed Status: This result is currently not released to :. Dispiay Full Result Report Display Order Report Page 3 of 3
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diff --git a/output/text/7018013d-a66a-4271-9cff-2aeeac44d792.txt b/output/text/7018013d-a66a-4271-9cff-2aeeac44d792.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fdf89a4c2c6f57e21c4581b18ac00799224e0aac
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+
+--- Page 1 ---
+UUID: EDF80CFD-4115-48E9-BF76-DDE957A97AEB -A5S0-01A-PR Redacted FINAL PATHOLOGIC DIAGNOSIS A. Breast, right, modified radical mastectomy: - Invasive ductal carcinoma, grade IIIII, 5.0 cm in greatest dimension, present 1.0 mm from posterior inked surgical margin, other margins widely free (see pathologic parameters and comment below) - Ductal carcinoma in-situ, high grade, solid type with associated central necrosis and calcifications, surgical margins negative. - Previous biopsy site identified - Metastatic carcinoma involving two of twelve lymph nodes (2/12) B. Breast, right, deep margin re-excision: - Skeletal muscle and fibroadipose tissue, negative for carcinoma C. Breast, right 'additional tissue under superiomedial skin flap,' excision: - Breast and fibroadipose tissue, negative for carcinoma D. Skin, right 'chest wall at corner of incision,' excision: - Skin and fibroadipose tissue, negative for carcinoma tcd-6-3 arcinoma, InA itratig Ducta/ NDS 8 5oo/3 Breast Pathologic Parameters 9L x/18/13 1. Invasive carcinoma: A. Gross measurement: 5.0 cm B. Composite histologic (modified SBR) grade: III/III. C. Associated intraductal carcinoma in situ (Dcis) - High grade, solid type with associated central necrosis and calcifications - Within main mass.
+
+--- Page 2 ---
+2. Surgical margins: Free of tumor. - DCis 3.0 mm from closest margin (posterior) - Invasive carcinoma 1.0 mm from closest margin (posterior) on mastectomy,. separately submitted deep margin re-excision (specimen B) negative for carcinoma - Additional margins widely free. 3. Blood vessel and lymphatic invasion: Present 4. Nipple: Uninvolved 5. Skin: Uninvolved 6. Skeletal muscle: Focally involved. 7. Axillary lymph nodes: Metastatic carcinoma involving two of twelve lymph nodes (2/12) - Size of largest metastatic deposit: 1.1 cm. - Extranodal extension: Present (2.0 mm) 8. Special studies . - ER: Weak expression in 30% of invasive tumor nuclei. - PR: No expression in invasive tumor nuclei. - Ki-67: 50% proliferation rate. - Her2/neu antigen (FIsH): Amplified (ratio: 3.8) 9. pTNM (AJCC, 7th edition, 201O): pT2, N1a, MX Clinical History: The patient is a  year-old female with right breast invasive ductal carcinoma. with axillary nodal metastases who undergoes right modified radical mastectomy.
+
+--- Page 3 ---
+Comment The 5.0 cm mass identified on gross examination is comprised of both invasive and in-situ carcinoma with extensive necrosis and calcifications.. Specimens Received: A: Right breast and axillary contents B: Additional deep margin C: Additional tissue under superiomedial skin flap. D: Skin at corner of incision; r chest wall. Gross Description: The specimens are received in four containers each labeled with the patient's name and medical record number. A. The first container is additionally identified as, 'right breast and. axillary contents'. Received fresh and placed in formalin is a 730 g simple. mastectomy specimen. The specimen is oriented with a double short suture designating the superior aspect and a double long suture designating the lateral
+
+--- Page 4 ---
+aspect. The breast measures 23 cm from medial to lateral, 21 cm from superior. to inferior, and 4.5 cm from anterior to posterior. On the anterior surface is 20 x 8.5 cm ellipse of skin with a 4.2 x 4.0 cm areola and a 1.3 x 1.3 x 0.5 cm nipple. The nipple-areolar complex reveals no evidence of ulceration or. retraction. There is an attached 6.5 x 5.5 x 1.5 cm portion of apparent axillary tail on the lateral aspect of the specimen. There is an attached 4.5 x 1.8 x 0.2. cm skeletal muscle consisting of pectoralis at the deep margin at junction of  upper-outer quadrant and lower-outer quadrant in slice3-5. The specimen is inked as follows: anterior-superior - blue;  anterior-inferior - green; posterior - black. The specimen is serially sectioned from lateral (slice #1) to medial (slice #11) to reveal a 5.0 x 3.8 x 3.5 cm pink-tan, firm mass (lesion #1) extending from upper-outer quadrant to lower-outer quadrant in slices 3-7. The mass is 1.6 cm from the anterior-inferior margin and abuts the posterior margin. Surrounding the mass is a 10 x 7 x 4 cm ill-defined, pink area composing of dilated ducts and fibrotic tissue in slices 4-9 and the most prominent in slice 7-8. The ill-defined area (lesion #2) extends towards anterior aspect and is 0.6 cm from. the closest anterior margin and 2.0 cm from the closest posterior margin. The remainder of the specimen consists of approximately 10% dense gray-white fibrous breast parenchyma and 90% lobulated yellow adipose tissue. No additional masses or nodules are grossly identified. Within the axillary tail are identified
+
+--- Page 5 ---
+several lymph node candidates measuring from 0.3-2.5 cm in greatest dimension. Block summary: A1: Lesion #1, slice 3 A2: Lesion #1, slice 4 A3: Lesion #1 abutting posterior margin, slice 5 A4: Lesion #1, slice 6 A5: Lesion #1, slice 7 A6: Lesion #2, slice 4 A7: Lesion #2, slice 5 A8: Lesion #2, slice 6 A9: Lesion #2, slice 7 A10: Lesion #2, slice 8 A11: Lesion #2, slice 9 A12: Representative adjacent medial to lesion #2, slice 10 A13: Representative adjacent lateral to lesion #2, slice 3 A14: upper-outer quadrant slice 2 A15: lower-outer quadrant slice 1 A16: upper-inner quadrant slice 11 A17: lower-inner quadrant slice 10 A18: nipple A19: skin A20: One lymph node A21-A23: 4 lymph node candidates, each cassette A24-A26: One lymph node, serial section
+
+--- Page 6 ---
+B. The second container is additionally identified as, 'additional deep margin;. underlying palpable tumor'. Received in formalin is a 3.9 g, 4.2 x 2.2 x 0.8 cm yellow-tan, soft tissue fragment with one short stitch designating as new true deep margin (inked blue) and attached clips on original margin (inked black) The specimen is serially sectioned and entirely submitted as B1-B5. C. The third container is additionally identified as, 'additional tissue under superiomedial skin flap'. Received in formalin is an unoriented 2.3 g, 4.8 x 1.2 x 1.1 cm portion of yellow-tan fibroadipose tissue, which is serially sectioned and entirely submitted C1-c2. D. The fourth container is additionally identified as, 'skin at corner of incision; right chest wall'. Received fresh and placed in formalin is an unoriented V-shaped ellipse of wrinkled, tan-brown skin measuring 4.5 x 1.5 cm adjunct with 3.2 x 1.5 cm excised to a depth of 1.3 cm. The specimen is serial sectioned and review grossly unremarkable parenchyma. The representative section is submitted as D1. Tissue fixed for at least 6 hours in 10% NBF and no more than 72 hours.
\ No newline at end of file
diff --git a/output/text/7019a810-0edb-4684-a22d-8b938259d540.txt b/output/text/7019a810-0edb-4684-a22d-8b938259d540.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9ccdbff3287210c2b86e86b132bb880d9d895a95
--- /dev/null
+++ b/output/text/7019a810-0edb-4684-a22d-8b938259d540.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+1cs-0-3 Cavin ono, InfiltraHng duct, nos 8500/3 PH 5rFx Cvde; brsot,cm#nL c C50.1 CQcF Sit: busot,Nss C50.9 10/1910 TSS Pt ID UUID:CFB8EE09-41D3-4A39-A4AE-4CDEC84BB9BC SPECIMENS: TCGA-E2-A10E-01A-PR Redacted A. WLE VULVA B. SENTINEL LYMPH NODE #1 C. SENTINEL LYMPH NODE #2 D. SENTINEL LYMPH NODE #3 E. SENTINEL LYMPH NODE #4 F. SENTINEL LYMPH NODE #5 G. LEFT BREAST H. LEFT AXILLARY CONTENTS SPECIMEN(S): A. WLE VULVA B. SENTINEL LYMPH NODE #1 C. SENTINEL LYMPH NODE #2 D. SENTINEL LYMPH NODE #3 E. SENTINEL LYMPH NODE #4 F. SENTINEL LYMPH NODE #5 G. LEFT BREAST H. LEFT AXILLARY CONTENTS GROSS DESCRIPTION: A. WLE VULVA Received is a vulvectomy specimen measuring 4 x 1.7 x 1 cm. The surface of the specimen is tan-gray and unremarkable. The single right stitch is arbitrarily designated 12 o'clock. The specimen is inked as. follows: 12 o'clock, 3 o'clock, 6 o'clock-blue, 6 o'clock, 9 o'clock, 12 o'clock-orange. The specimen is serially sectioned from right to left and submitted in toto as follows: A1: 12 o'clock right margin A2-A4: full thickness sections from right to left A5: 6 o'clock left margin B. SLN #1: Received fresh is a tan pink lymph nodes 1.0 x 0.9 x 0.5cm. The specimen is bisected, touch preps are taken and the specimen is submitted in toto in FSB. C. SLN #2: Received fresh is a tan pink lymph nodes 0.5 x 0.3 x 0.3cm. The specimen is bisected, touch preps are taken and the specimen is submitted in toto in C1.. D. SLN #3: Received fresh is a tan pink lymph nodes 1.0 x 0.5 x 0.5cm. The specimen is bisected, touch preps are taken and the specimen is submitted in toto in D1. E. SLN#4: Received fresh is a tan pink lymph nodes 1.5 x 1.3 x 0.5cm. The specimen is bisected, touch preps are taken and the specimen is submitted in toto in E1. F. SLN#5: Received fresh is a tan pink lymph nodes 1.0 x 0.9 x 0.5cm. The specimen is bisected, touch preps.are taken and the specimen is submitted in toto in F1. G. LEFtBREAST: Received fresh is a 474 gram simple mastectomy specimen measuring 21 x 19 x 3.5 cm. The specimen is partially surfaced with a tan-pink ellipse of skin measuring 16 x 16 cm. The skin surface is remarkable for a centrally located partially raised nipple 1 cm. The areola rim measures 1.3 cm. The specimen is inked as follows: superior anterior-blue, anterior inferior-orange, posterior-black. The. specimen is serially sectioned from lateral to medial into 10 slices; slice serially sectioned from medial to lateral in 10 slices; slice 1 the most medial, slice 10 the most lateral. The nipple is located in slice 5. and 6. The cut surface reveals a gray-white firm well circumscribed mass measuring 2.5 x 1.5 x 1 cm, Iocated in slice 5 and 6 and measuring 0.7 cm. from the closest deep margin. The mass is retroareolal measuring 2 cm. deep from the nipple. A second satellite nodule is identified in slice 8 measuring 1 x 0.9 x 0.8 cm, 0.4 cm. from the deep margin and 5.5 cm. from nodule #1. A third possible satellite nodule is grossly identified in slice 7 measuring 0.4 cm. in greatest dimension, greater than 0.1 cm. from. the deep margin and 2.0 cm. from nodule #2 and 4 cm. from noduie #1. Nodule 2 and 3 are both Iocated in the lower outer quadrant. Remaining cut surfaces reveal predominantly yellow lobulated adipose tissue inrterdispersed with gray-white fibrous tissue. A portion of the specimen is submitted for tissue procurement. Representative sections are submitted as follows: G1: nipple serially sectioned slice 5. G2: nipple serially sectioned slice 6 G3: upper inner quadrant sice 3 G4: upper inner quadrant with deep margin slice 4 G5: lower inner quadrant slice 3
+
+--- Page 2 ---
+G6: lower inner quadrant slice 4. G7: area immediately adjacent to mass #1 G8; slice 4 G9: slice 5 G10: upper central slice 5. G11: lower central slice 5. G12: skin adjacent no nodule #1. G13-G14: nodule #1 with closest deep margin slice 6 G15: area above nodule #1 slice 6 G16: immediately adjacent to nodule #1 with deep margin slice 7 G17: nodule #3 with deep margin slice 7 G18: lower outer quadrant slice 7 G19: area immediately adjacent to nodule #2 with deep margin slice 7 G20: upper outer quadrant with deep margin slice 8. G21: inferior margin lower outer quadrant adjacent to nodule #2 slice 8 G22: nodule #2 with deep margin slice 8 lower outer quadrant G23: area immediately adjacent to nodule #2 with inferior and deep margin slice 9 H. LEFT AXILLARY CONTENTS: Received in formalin are multiple tan-pink fragments of fibrofatty tissue aggregating to 7 x 6 x 3 cm. Dissection reveals 15 possible lymph nodes ranging from 0.1 x 0.1 x 0.1 cm to 2 x 1.5 x 1 cm. Section code: H1: Five possible lymph nodes H2: Five possible lymph nodes H3: Four possible lymph nodes H4: One lymph node serially sectioned. DIAGNOSIS: A. VULVA, WIDE LOCAL EXCISION: - MODERATE TO SEVERE SQUAMOUS DYSPLASIA (VIN II-III) - MILD SQUAMOUS DYSPLASIA PRESENT AT 12 O'CLOCK TO 6 O'CLOCK MARGIN, SEE NOTE 1. B. LYMPH NODE, SENTINEL #1, LEFT AXILLA, BIOPSY: - METASTATIC CARCINOMA TO ONE OF ONE LYMPH NODE (1/1), MEASURING 3.5 MM WITH EXTRANODAL EXTENSION. C. LYMPH NODE, SENTINEL #2, LEFT AXILLA, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (O/1) D. LYMPH NODE, SENTINEL #3, LEFT AXILLA, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (O/1) E. LYMPH NODE, SENTINEL #4, LEFT AXILLA, BIOPSY: - METASTATIC CARCINOMA TO ONE OF ONE LYMPH NODE (1/1), MEASURING 1.2-CM WITH NO EXTRANODAL EXTENSION. F. LYMPH NODE, SENTINEL #5, LEFT AXILLA, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (O/1). G. BREAST, LEFI)SIMPLE MASTECTOMY: - THREE FOCI OF INVASIVE, DUCTAL CARCINOMA, SBR GRADE 1, LARGEST MEASURING 1.8-CM - SURGICAL RESECTION MARGINS NEGATIVE FOR TUMOR - TUMOR (LARGEST FOCUS) IS 2.5-MM FROM THE DEEP SURGICAL RESECTION MARGIN - LOW NUCLEAR GRADE, DUCTAL CARCINOMA IN SITU, MICROPAPILLARY, CRIBRIFORM AND PAPILLARY TYPES - PERINEURAL INVASION IDENTIFIED - SEE SYNOPTIC REPORT AND SEE NOTE 2 H. LYMPH NODES, LEFT AXILLARY CONTENTS, DISSECTION:
+
+--- Page 3 ---
+- SIXTEEN LYMPH NODES, NEGATIVE FOR METASTASES (0/16). NOTE 1: Mild squamous dysplasia is present at the 12 o'clock-3 o'clock-6 o'clock margin in multiple. Ievels. Focally, this margin has cautery artifact which precludes the assessment of degree of dysplasia.. NOTE 2: Three foci of invasive ductal carcinoma are identified; largest measuring 1.8-cm is located centrally. The other two foci measure 1.0-cm and 0.4-cm respectively. All surgical resection margins are free of tumor. The closest margin is posterior (2.5 mm from the largest tumor mass) SYNOPTIC REPORT - BREAST Specimen Type: Mastectomy Needle Localization:  No Laterality:(Leff) Invasive Tumor: Present Multifocality: Yes WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Tumor size: 1.8cm Tumor Site:  Central. Margins: Negative Distance from closest margin:  0.25cm deep Tubular Score: 2 Nuclear Grade: 2 Mitotic Score: 1 Modified Scarff Bloom Richardson Grade: Necrosis: Absent Vascular/Lymphatic Invasion:  None identified Lobular neoplasia: None Lymph nodes: Sentinel lymph node and axillary dissection Lymph node status: Positive 2 /21 Extranodal extension Micrometastases: No DCIS present Margins uninvolved by DCIS DCIS Quantity: Estimate 2% DCIS Type: Cribriform  Micropapillary  Papillary DCIS Location: Associated with invasive tumor Nuclear grade: Low Necrosis: Absent Location of CA++: DCIS Benign epithelium ER/PR/HER2 Results ER: Positive PR: Positive HER2: Negative by FISH Performed on Case: Pathological staging (pTN): pT 1c N 1a CLINICAL HISTORY: None given PRE-OPERATIVE DIAGNOSIS: Multifocal invasive ca. left breast
+
+--- Page 4 ---
+INTRAOPERATIVE CONSULTATION: FSB/TPB: Positive for tumor cells. Diagnosis called to Dr. at by Dr TPC/TPD/TPF: Negative for tumor cells. Diagnosis called to Dr at  by Dr. TPE: Positive for tumor cells. Diagnosis called to Dr. at )y Dr. Gross Dictation:., Patholonist Gross Dictation: Microscopic/Diagnostic Dictation: Pathologist Microscopic/Diagnostic Dictation: Pathologist, Microscopic/Diagnostic Dictation:.. Patholoaist Final Review.., Pathologist, Final: Pathologist,
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diff --git a/output/text/701d2395-bc4a-41e5-af98-1073500fd33c.txt b/output/text/701d2395-bc4a-41e5-af98-1073500fd33c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..abdbe2e5219058a356db02cd927cc79032d562ba
--- /dev/null
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@@ -0,0 +1,3 @@
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+--- Page 1 ---
+1cs-0-3 cascnomn, infi/matng dluct; N0S 8500]3 UUID:ACC0A0E7-218F-4112-AC74-9F5D5A512DD3 Site; brenst, N0s Redacted c50.9 page 1 / 1 5119/u copy No. 5 Date: Examination: Histopathological examination Internal invoice No. Value of diagnostic procedure Examination No.: Patient: XXX PESEL: XXX Age Gender: F Material: Multiple organ resection' right breast  Unit in charge:  Physician in charge: Material collected on Aaterial received on: : Expected time of examination: up to 8 working days Clinical diagnosis: Cancer of the right breast Examination performed on: Macroscopic description: Right breast'sized 17.2 x 13.2 x 4.4 cm removed without axillary tissues and with a skin flap of 14.4 x 7.2 cm. Weight 345 g. Tumour sized 1.2 x 1.4 x 0.9 cm found on the boundary of upper quadrants, located 4.3 cm from the upper boundary, 0.8 cm from the base and 1.6 cm from the skin. Microscopic description: Carcinoma ductale invasivum - NHG1 (1 + 2 + 1 : 0 mitoses/10 HPF - visual area: 0.5Smm).  Numerous foci of carcinoma ductale in situ Dcis found within the tumour (micropapillary type with medium nuclear atypia and comedo necrosis, 70% of the tumour volume). Mamilla sine laesionibus. Glandular tissue showing parenchymal atrophy. Examination result: Carcinoma ductale invasivum mammae dextrae. Invasive ductal carcinoma of the right breast? (NHg1, pTic, pNO (SN)). Compliance validated by: Examination performed c Results of immunohistochemical examination: Estrogen receptors found in 75% of neoplastic cell nuclei. Progesterone receptors found in 10% of neoplastic cell nuclei. HER2 protein stained with Ventana's Pathway HER-2/neu (4B5) Rabbit Monoclonal Antibody. Negative reaction in invasive cancerous cells (Score=1+). Compliance validated by:
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diff --git a/output/text/702b9311-66e0-4c1a-abd6-10f5b6ab72b2.txt b/output/text/702b9311-66e0-4c1a-abd6-10f5b6ab72b2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..06f1ead9a53a4c8b13c91a79bcca34c69807ceec
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+i(b- 0 - 3 lnfilt^aHNg duct, N0s 85ouf3 Carcinoma PATIENT HISTORY: Site lole : Krest, Nos c 50.9 The patient is a year-old female with no clinical history given. Date of Tast menstrual period: Not given.. PRE OP DIAGNOSiS: Breast cancer. Post op Diagnosis: Same. PROCEDURE: Left totai mastectomy and sentine! node biopsy, Hepatitis C. UUID:E4DF4771-074D-4870-A03F-AF62724C5A86  TCGA-BH-A18L-01A-PR  Redacted FINAL DIAGNOSIS: Part 1: sentinel Lymph node, Left, #1 - Lymph nODe pOSItIvE fOR SEVErAL MICrOmetaStASES, AppROxImATeLy 0.1 Cm EACH, ViSIbLe On IMMUNOSTAIN SLIDES AND TWO LEVELS OF THE H&E STA!N SECTIONS. Part 2: SentInel Lymph NODe, Left, #2 - NEgative fOr metastAtic tumOR (see comment). PARt 3: NON-SENTiNEL LymPH NODE, LEfT --  Negative for metastatic tumor. Part 4: breast, Left, total mastectomy - A.  INFiLTRATiNG DUCTAL CARCINOMA, nOTTInGhAm SCORe 7i9 (TUBULeS 3, nUCLEAR PLeOmORPHISm 2, MitOsis 1) 6.0 X 5.0 X 6.0 Cm. B.  DUCTAL CARCINOMA IN SiTU, SOLID AND CRIBRIFORM TYPES REPRESENTiNG, APPROXIMATELY 5% OF TOTAL. TUMOR VOLUME. C. Skin wIth tumor in the LOWer dermIs. D. LINES OF RESECT!ON ARE FREE OF TUMOR. (See comment) COMMENT: The tumor is approximately 0.1 cm from the inferior surgical resectlon margin. The ductal nature of the tumor is. confirmed by a strongly positive E-cadherin immunostain.
+
+--- Page 2 ---
+MICROSCOPIC: SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST A. Lateratity: 2 1. Right 2. Left B. Procedure: 3 1. Segmentectomy 3. Modified radical mastectomy 2. Simple mastectomy 4. Re-excision C. Location: 2 1. Central subareolar 4. LOQ 2. UOQ 5. LIQ 3. uiQ 6. Not specified D. Size of tumor (maximum dimension invasive component by gross or microscopic exam): 6.0 cm 1. Ductal, NOS 5. Cribriform 9. Metaplastic 2. Tubular 6. Papillary 10. Other 3. Mucinous 7. Lobular 4. Medullary 8. Carcinoid like F. If lobular carcinoma, specify type:  N/A 1. Classical 4. Signet ring 7. Pleomorphic 2. Solid 5. Trabecular 3. Alveoiar  6. Tubulobular G. Nottingham Score: G1. Nuclear grade: 3 G2. Tubule formation: 3 G3. Mitotic activity score: 1 G4. Total Nottingham score: Z G5. Nottingham grade (1, 2, 3): 2 H. Angiolymphatic invasion: 1 1. No 2. Yes I. Dermal lymphatic invasion: 2 1.Yes 2. No 3. Not applicable J. Calcification: 1 1. No 2. Yes -- benign zones 3. Yes -- malignant zones K. Type of in situ component: 1/2 1. Cribriform 4. Micropapillary 7. Lobular 2. Solid 5. Apocrine 3. Papillary 6. Comedo L. Percentage of tumor occupied by in situ component:  5% M. Surgical margins involved by invasive component: 1 1. No 2. Yes - focal 3. Yes -- diffuse N. Surgical margins involved by in situ component: 1 1. No 2. Yes - focal  3. Yes - diffuse O. Paget's disease of nipple: 2 1.Yes 2. No P. Number of positive lymph nodes: 1 Q. Total number of lymph nodes examined:3 R. Sentinel node metastasis: 1 1. Yes 2. No S. Only micrometastases to lymph nodes (none larger than 0.2 cm): 1 1.Yes 2. No T. Metastasis/es to a lymph node 2 cm. or more in greatest dimension: 2 1. Yes 2. No U. Lymph node metastasis/es with extracapsular extension:2 1. Yes 2. No V. Metastases to ipsilateral internal mammary lymph node (if applicable): N/A 1. Yes 2. No W. Skin involved (uiceration): N/A 1. Yes 2. No X. Non-neoplastic breast tissue: 6 1. ADH 4. Fibroadenoma 7. LCIS 2. ALH 5. Papilloma 8. Other 3. Radical scar 6. FCD Y. Multicentricity/multifocality of invasive foci: 2 1. Yes 2. No Y1: Sizes of invaxive foci: # cm/ # cm /# cm Y2: Aggregate diameter of Y1 tumors: # cm Z. TNM stage: T3N _mX
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diff --git a/output/text/7037d22d-8692-4b72-81ec-6002b462d2a1.txt b/output/text/7037d22d-8692-4b72-81ec-6002b462d2a1.txt
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index 0000000000000000000000000000000000000000..f42d0e41328ceec5c60edc3d6dd1b12c896dcbce
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+
+--- Page 1 ---
+TCGA #: Sample ID #: Diagnosis: This is a poorly differentiated adenocarcinoma of the ascending colon with extensive. anaplastic areas of solid carcinoma, with a histopathological grade G3 to 4 differentiation. with ulcerations of the inner tumor surface, with necroses, with. peritumorous, chronic recurrent inflammation, with tumor infiltration in the layers of the colon wall as far as the subserous fatty connective tissue, with carcinomatous. lymphangiosis, with moderate chronic lymphadenitis of the tumor-free lymph nodes. (0/16), as well as tumor-free overview sections from the resection margins and from the reticular fatty tissue. According to these prepared sections, the tumor spread of the colon carcinoma corresponds to the tumor stage pT3, pN2, MX, L1, R0 10+ 1ls-0-3 adnrcucioma, Nos81yo|3 UUID:C5E7082D-B5A0-4BF7-8929-9F6715A02276 Redacted
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diff --git a/output/text/705d4029-42b2-4e89-ba60-8f0e5d99c9ab.txt b/output/text/705d4029-42b2-4e89-ba60-8f0e5d99c9ab.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6aeac89e9516369cded764ff32aad73a37023705
--- /dev/null
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+
+--- Page 1 ---
+1Cs-0-3 1/a1/ p Nos C50.9 Sit: breast, SUrgical REpOrt Name: Pathology Number: Sex: F Date Collected: : DOB: Date Received: M.R. Numbel Location: . Account Number Doctor: PRE-OPERATIVE DIAGNOSIS RIGHT BREAST CANCER POST-OPERATIVE DIAGNOSIS RIGHT BREAST CANCER PROCEDURE RIGHT BREAST LUMPECTOMY WITH FULL AXILLARY NODE DISSECTION TISSUES A. BREAST EXCISION,NEEDLE LOC,SIMPLE,MARGINS,ETC. - RIGHT BREAST LUMPECTOMY B. AXILLARy - COnTeNTSE C. mArGIns - RIght BreaST FS DIAGNOSIS RIGHT BREAST LUMP (GROSS MARGINS) - UUID: 754687FB-1976-4994-AF87-6270382D44D7 A. TCGA-A2-A0T1-01A-PR Redacted TumOR EXTenDs TO SupeRiOr MargIn, NeaR SKIn. (Reported to surgeon: Diagnosed by: FINAL DIAGNOSIS A.  RIght.breaSt Lump Needle LOC - POOrLy DiffErenTIateD InVasive DUctal CArcinomA, 7.5 Cm. in GREateSt DImENSION, EXTENDiNG TO SUPERiOR INKED SURGICAL MARGIN. SCARFF-BLOOM-RICHARDSON BREAST CANCER HISTOLOGIC SCORE, 9 (3+3+3). HIGH NUCLEAR GRADE DUCTAL CARCINOMA IN-SITU (DCIS) COMPONENT WITH CENTRAL NECROSIS AND CALCIFICATION EXTENDS WITHIN LESS THAN 0.1 CM. Of the SuperiOr Surgical margin. REMAINING DESIGNATED SURGICAL MARGINS ARE FREE OF TUMOR. PAThOlOgIC TNm STAge: T3 N3 mX, STage iIIC, g3, iNVaSIVe DUctal CARcinOMA. PQRI CATEGORY II: 3260F. B. AXILLARy CONTENTS - TEN (10) REGIONAL LYMPH NODES POSITIVE FOR METASTATIC iNVASIVE Pathology Number: Pationt Name Page 1 of 2 SURGICAL REPORT
+
+--- Page 2 ---
+Pathology Number: Patient Name. DUCTaL CARCInoMA. C. RIght Breast marginS - SKIN AND ATTACHED FIBROFATTY BREAST TISSUE, NEGATIVE FOR MALIgNANCY.E Diagnosed by: ( Revlawad a d out by: GROSS DESCRIPTION  ynated A, B, The specimen is received in three separate containers labele. c. A. The container is received fresh unfixed labeled "right breast lump" and consists of a 67 gm. ovoid. mass of apparent fatty and fibrous-encased tissue which is 7.5 : 7.5 x 3 cm. in greatest overall dimension. The attached skin ellipse is 4 x 1 cm. There is a single short suture indicating superior margin inked with black dye, inferior is inked orange. There is a single long suture. indicating lateral margin inked with blue dye, medial is inked green. The skin represents the anterior margin, posterior is inked with red dye. Sectioning reveals an irregular bordered tan-gray firm slightly whorled nodule with scattered hemorrhagic areas varying up to 3.5 cm. in greatest overall dirmension and grossly appears to be less than 0.1 cm. from the suberior margin and The tumor directly beneath the ellipse of skin. Gross margins are observed by Dr.. mass grossly appears to be approximately 1.5 cm. from the inferior, 1 cm. from the lateral, 1 cm. trom the medial directly beneath the anterior, and 1 cm. from the posterior. The specimen is submitted in twelve blocks. Key Note Block Summary: 1---superior, 2---inferior, 3-- lateral, 4--- medial, 5--- anterior, 6--- posterior, 7 through 12--- random.. 8. The container is received fresh unfixed labeled "axillary contents" and consists of an irregular mass of apparent fat which is 13 x 12 x 4 cm. in greatest overall dimension. Sectioning reveals firm tan-gray nodules varying up to 7 cm. in greatest dimension. The Iargest has scattered green-. black areas and scattered yellow-tan chalky material. The specimen is submitted in seven blocks. C. The container is received fresh unfixed labeled "additional right breast margin --skin represents the anterior margin, suture on new superior margin' and consists of an ellipse of skin with attached underlying soft tissue which is 7 x 2.5 x 0.4 cm. in greatest overall dirmension. There is. an attached suture indicating new superior margin inked with black dye. The entire specimen is. submitted in five blocks. MICROSCOPIC EXAM MICROSCOPIC EXAMINATION CONDUCTED BY PATHOLOGIST CONFIRMS FinAL DIAGNOSIS.E Pathology Number: Patient Name. Page 2 of 2 SURGICAL REPORT
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diff --git a/output/text/707be64a-1b85-401c-879d-c4a812c77955.txt b/output/text/707be64a-1b85-401c-879d-c4a812c77955.txt
new file mode 100644
index 0000000000000000000000000000000000000000..64b9ca9bc92786c76fcc8b5e8612ed6ee3853502
--- /dev/null
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+
+--- Page 1 ---
+PATHOLCGIC HIAGNOSTS APECMEN LABELEDLEFTKDNEY h.LL cARciNoA (5.5 cm).predominantly Chromophobe type, Fuhrman grade v o v in a background ot II of Iv.See note. 1s well eircmsribnd and confined ro the kidney. does not nvade rena pelvis.  vanlar and uretera resection maxyins are frce of tumor NoTi; Many tumc cclls ae positive tor Halc's colloidal iron (chronophobe ccmponent), but the tunor also has teatures of cocytoma this is consistert with a mixed type cumor SPECMEN LADELEREGONAI. LYMPH NODES S (s lymph rodeno tumor presert Ac stage(6th d1b NO Mx LINCAL DATA istory: 5 year-cld with ircidental firdings of soiid mass left kidney. Corat cn: Nephrectomy. Orerative rindings: Not provided. nicl niagross: Incidental lef kidney mass TISSUE SUAMITTED: Ictt kidney. /2. Regiora 1ymph nodes DESCRIPION  spccil s received resh, in twc parts, cach labeled with the patient?s a nd crit ramber  A,aboied #1.Left kidney" consists of a 603.5 gm left nephrectcmy rei iluding kidney 12.5 x 6.5 x3.3 cm) and surrounding perirenal tat ray frcm 0.9 cm.to 2.2 cm in thickness. Extending from the renal pelvis a sgment cf ureter ll.0 cm in length with a diameter ranging from o.1 cm roximlly up to C.4 cn distally)bifurcated renal vein (averaging 0.4 cm in gth x 0.s cin ir. diaeter.renal artery 0.6 cm x 0.3 cm in diameter. The scimen is inked biack and secsioned to extibit a circumscribed bulging mass 7 cm in thc lateral lower pole. Thc mass is approximately 75% .ssy yellow/:an lcbulated and solid with a peripheral component homornacc Thc mass is 8.5 cn from the uretcral margin. era artery margin, and 4. cm from the renal vein margin. Upon scct.ioning, e mass exlibts a variegated focally hemorrhagic red/browr to yelow/tan focaly tibrotic cut surface and grossly appears to cxpand but not grossly invarle through thc renai capsule, pushing into the adjacent perincphric fat and The mass is approximately 85 solid and 15* friable to necrotic. The remainder o the renal cortex is tan/brown with a well-defined cortical medllary janction. The pelvccaliccal system exhibits smooth glistening tan wrokelium with no masscs cr lcsions identified. The adrenal gland is not present. The perinephric fat is thinly sectioned but ro lympn node candidates The specimen is photoyraphed. Representative sections of centified. aiven to Cyzogenetics, Electron Microscopy and the Pag Iof
+
+--- Page 2 ---
+Pathology Report Tissue Bank. Representative normal kidney was prev.ously sent for Elect.ron Microsccpy,Immuncfluorescence, and given to the Tissue Bank Micro Al:Creteral and vascular margins, en face,4 frags Micro A2: Tumor and capsule and closest approach to black inked maxgin,trag, RSS. Micro A3:Tumor capsule and perirenal at,1 frag Micro A4:Tumor toinclude junction of fleshy yellow/tan componont. wh fibrotic red/brown to tan component, 1 frag,Rss. Micro A5: Tumor and adjacent uninvol.y vod kidrey and renal sirus1 frag Micro A6: Uninvolved kidney,1 frag, Micro A7:lnirvolved calyx and unremarkable urothelium.1 frag fibrofatty tissue 3.9 x 2.4 x 1.1 cmwhich is dissected for lymph ode candidates. Eight pink/tan rubbery lymph node candidates (ranging from .2 cm to l.0 cm in grcatcst dimension are identified and are entireiy submistcc as follows: Micro B1: 2 lymph nodc candidates, ? frags, Micro B2:3 lymph node cand:dates..3 frags, Micro B33 smal lymph node candidates, By his/her signature below, the senior physician certifies that he/she personally conductcd a microscopic examinasicn "gross only exam if so stat.ed related therct.o ADDENDUM FOR KIDNEY PARENCHYMA NOT INVOIVED BY TUMOR PATHOLOGIC DIAGNOSIS KIDNEY WITH MILD FOCAL GLOBAL GLOI EROSIS5SEE NOTE ARTERIAI AND ARTERIOLAR SCLEROSIS, WITH SUBINTIMAL HYALINOSIS SEE NOTE NOTE: This surgical specimen of non-tumoral kidney does not reveal significant. findings in the parerchyma. Namely, the glomeruii show 5% focal global compartment. There is only mild vascular sclerosis and foca intimal hyal:nosi present MICROSCOPIC DESCRIPTION: The sample consists of kidney cortex and medulia. There are up c two hundred eighty-thrce glomcruli present in the sample submitted for light microscopy. Fourteen (14) glomcruli arc globally obsolcscent (53). The preserved glomeruli show very mild signs of hypertrophy, with subtie increass in cellularity and mesangial matrix. On PAs and Jones  siver methenamine stair, the glomerular basement mcmbranes appear of rormal thickness.No "spikes" or craters arc recognized. Tubules are well preserved; occascna active inflamnation. Less than St of the sample shows tubular atroply and interstitial fibrosis, as evidenced on the trichrome stains (AFog); these areas are mostly subcapsular in location. mild sclerosis ot the wall with subintimal hyalinosis.. Pare2
+
+--- Page 3 ---
+RCtT oo12 Prit1128200510:40 Page3
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diff --git a/output/text/707c9763-b744-4d39-83fb-7df5093c6916.txt b/output/text/707c9763-b744-4d39-83fb-7df5093c6916.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b70458aac35e3a9dab49ac69556d00e063960a9a
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+--- Page 1 ---
+1cD-0-3 sih> brnst Nos' c50.9 85Q0/3 UUID:E50118BD1-E1DE-4A47-BF3C-66BA1E0B84DC TCGA-D8-A27V-01A-PR Redacted page 1 / 1 original Examination: Histopathological examination. Internal invoice No. Value of diagnostic procedure. Examination No.: ' Patient: XXX PESEL: XXX Age: 1 Gender: F Material: Total organ resection -- right breast # Unit in charge.  Physician in charge: Material collected on: Material received on: Expected time of examination: up to 8 working days. Clinical diagnosis:  Examination performed or Macroscopic description: Right breast'sized 1.,2 x 11.2 x 3.6 cm removed without axillary tissues and with a skin flap of 13.2 x 16.3 cm. Weight 200 g. Tumour sized 3.2 x 1.8 x 2.8 cm on the boundary of outer quadrants, located 1.8 cm from the outer boundary, 0.3 cm from the base and 0 cm from the skin. Microscopic description: Carcinoma lobulare invasivum (classical type) - NHG2 (3+2+1: 0 mitoses/10 HPF - visual area: 0.55mm). Infiltratio carcinomatosa cutis mammae. Mamilla sine laesionibus.. Glandular tissue showing adenosis sclerosans et calcifications. Histopathological diagnosis: (including Examination Carcinoma lobulare invasivum mammae dextrae. Invasive lobular carcinoma of the right breast. (NHG2, pT2, pN0/sn/). Compliance validated by:
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diff --git a/output/text/70d2c13a-d968-4123-aede-7b7c5e74e420.txt b/output/text/70d2c13a-d968-4123-aede-7b7c5e74e420.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0f41396b7ac40312c464207ef3c836c3d2bbba6a
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+
+--- Page 1 ---
+UUID:F3CD8E6E-B02F-4D5D-B895-6DF063F61603 TCGA-GM-A2DA-01A-PR Redacted 1Cs-63 Cavcn`nNu, wfn[tnsHxy duct, 1os 8.50o/3 St: bArt w0s C5U.9 L ?: ... tINAL DAF+St 1.n'y: CONSULTANT: TIMe RFCn: SURGERY Dx COMPlETED: I4 COPy TOsh CLINIC COPY D):N )IAG JOSIS : (A) RIGHT DREAST AND AXILLARY CONTENIS: I VASIVF MUCTAL CAKCINOMA. JLACK'S NUCLEAR GRACE II. (SEE COMMENT) Fibrocystic changes. 'IETASTATIC CARCINOMA IN TO) JF THIRTEFN AXILLARY LYMPH JODES. (SEE COHMENr) largins of resection free of tumor. COMmfNt: The ndin tunor nass measures 2.5 x 2.0 x 1.5 cm in areatest. timensions and is locatey in the inner quadrant. A separate nicroscopic focus ot invasive tunor is located in the upper outer quadrant and neasures 1.5 x 1.0 x 0.5 mm. The taraest tymph node containing netastatic disease. easuros l.5 x 1.J x 0.5 cm and shows So% reotacement by tumor. Jne of the lynoh nodes containing netastatic tumor  shows several foci of extracapsular xtension cumulative area ot j.0 x 5.5 nm. GROSS DESCriprioN: (A) RIGHT 34EAST AN9 AXILLAnY CONTENTS - The specimen (25 x 15 x 4 cm) consists of breast (ls x 13 x 2 cm) covered by an unremarkable skin elliose (3 x 5 cm) with nipple. The axit(ary contents measure 12 x 5 x ').l cn. A nass is iuentified in the inner quadrant and measures 2.s x ?.) I.5 cin. The nass is O.s cm from the deep surgical .nargin. The inass is d.5. cn away trom the nedial nargin and 5 cm away from tne niopte. 2.s cm awsy from the inferior naryin and ) cm away from the superior narjin. The rest the oreast parenchym shows fibrosis. No other nass is bresent Stctiny Cune: Al. tumor with deep surjic3l maryin; A2-a7. sections. ot tumor: A3, inner uoper quadrant periyherat: A9. inner lower auadrant centr3l 1lJs inner lower quatrint perioheral; Ail, outer uoper quadrant werioheral: 1l?, outer upoer quadrant central: Al3. outer lower juadrant central: Al4. outer loser quadrant perioherat: Als, Ale. nipptei Al7. two lynpn nojes: Al ne lymph note: 11?, one tynph note; 420, three lymph noaes: A2l, two lyrpn. nodes: A22. two lynpn notes; A2s, one lynpn note. hisect n; A24. one,. 1 v70h REPORT OF TISSUE DIAGNOSIS
+
+--- Page 2 ---
+note. .ortion of the tumor is subnitted for ftow TECHNICAL ChARGES: REPORT OF TISSUE DIAGNOSIS
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diff --git a/output/text/70e80c32-b101-4216-8787-54c2c441577d.txt b/output/text/70e80c32-b101-4216-8787-54c2c441577d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7e4ab9483392b236dc0687a3c7860a314aa3dbbf
--- /dev/null
+++ b/output/text/70e80c32-b101-4216-8787-54c2c441577d.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1cs-0-3 UUID: 12A4A731-1ADF-4D36-88F3-16C9642484F3 cartioma,mfilmatng cuct! Nvs 85oo/3 Redacted TCGA-AR-A0TY-01A-PR Sih: brost, nos c50.9 Breast, right, simple mastectomy: Infiltrating ductal carcinoma, Nottingham grade III (of Hl) is identified forming a 2.4 x 2.2 x 1.8 cm mass (AJCC pT2) in the right upper outer quadrant of the breast. A significant component of in situ carcinoma is not identified. A benign fibroadenoma (0.6 x 0.4 x 0.4 cm) is identified in the upper inner quadrant. Skin, nipple, and resection margins are free of tumor (closest is anterior/superior, free by 3.8 cm). Multiple (8) right axillary lymph nodes are negative for tumor. Lymph nodes, right axillary sentinel, excision: Multiple (7) right axillary sentinel lymph nodes are. negative for tumor [AJCC pNo(sn-)]. Blue dye is identified in right axillary sentinel lymph nodes No.1A and No.1B. Blue dye is not identified in right axillary sentinel lymph nodes No.1C, No.1D, No.1E, No.2, and No.3. Immunohistochemical cytokeratin stain was performed on the paraffin embedded sentinel lymph node tissue and confirms the H&E impression. Breast, left, simple mastectomy: Benign breast tissue with non-proliferative fibrocystic changes. characterized by apocrine metaplasia, cyst formation, and multiple (2) fibroadenomas (upper inner. quadrant, 0.9, and inferior central, 1.1 cm). A single left axillary lymph node is negative for tumor. Estrogen and progesterone receptor analysis and Her-2/NEU have been ordered on paraffin embedded tissue from the right breast.
\ No newline at end of file
diff --git a/output/text/70fce709-f796-4a1b-adcf-777e3c1eee88.txt b/output/text/70fce709-f796-4a1b-adcf-777e3c1eee88.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2772a2e5c63101acdf62ad0a6aa069080c81afa3
--- /dev/null
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+
+--- Page 1 ---
+SURGICAL PATHOLOGY REPORT Clinical Diagnosis & History: Colon cancer. Specimens Submitted: 1: SP:colon, Right ; resection DIAGNOSIS: 1. SP:colon, Right ; resection: Tumor Type: Histologic Grade: Poorly differentiated with signet ring cells Tumor Location: Cecum Tumor Size: Length is 8.5 cm Width is 7.0 cm Maximal thickness is 1.1 cm Tumor Budding: Extensive Increased Tumor Infiltrating Lymphocytes: Absent Precursor Lesions: Tubulovillous adenoma Deepest Tumor Invasion:. Subserosal adipose tissue and/or mesenteric fat Gross Tumor Perforation: Not identified Lymphovascular Invasion: Identified extensive. Large Venous Invasion: Identified Perineural Invasion: Identified Surgical Margins:. Free of tumor Polyps/Mucosa Dysplasia (away from the carcinoma): Tubulo-villous adenoma; number: 3 ** Continued on next page **
+
+--- Page 2 ---
+Page 2 of 3 Non-Neoplastic Bowel:. Unremarkable Appendix: Unremarkable Lymph Nodes: Number with metastasis: 11. Total number examined: 40 Tumor deposits in pericolorectal soft tissue: Identified Identified; number:3 Tumor Staging (AJcc 7th Edition) : pT3 (Tumor invades through the muscularis propria into pericolorectal tissues) Lymph Node Stage (AJcc 7th Edition): N2b (Metastasis in seven more regional lymph nodes) NOTE: IMMUNOHISTOCHEMICAL STAINS SHOW THAT THE TUMOR CELLS ARE POSITIVE FORS CK2O, CDX2, AND VERY FOCALLY POSITIVE FOR CK7, WHILE NEGATIVE FOR SYNAPTOPHYSIN, CHROMOGRANIN, ER AND PR. THE RESULTS ARE CONSISTENT WITH A PRIMARY COLON CARCINOMA. Some of the immunohistochemistry and Ish tests were developed and their. performance characteristics were determined by the Department of Pathology.. They have not been cleared or approved by the Us Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for research. This laboratory is certified. under the Clinical Laboratory Improvement Amendments of I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. 1. The specimen is received fresh, labeled "Right colon" and consists of a segment of terminal ileum, cecum with attached appendix and ascending colon.. The terminal ileum measures 11.5 cm in length and 3.3 cm in circumference at the proximal resected margin.  The remaining colon measures 46 cm in length with a circumference of 7.5 cm at the distal resected margin.  The attached appendix measures 5 cm in length and averages 0.8 cm in diameter The appendiceal and intestinal serosa is pink tan and smooth. Focally ** Continued on next page **.
+
+--- Page 3 ---
+ Page 3 of 3 hemorrhagic lobulated yellow tan adipose tissue spans the length of the specimen measuring up to 2.0 cm in thickness. The specimen is opened to. reveal a partially fungating and partially infiltrating lesion measuring 8.5 cm in length and 7 cm in width. The mass is located in the cecum, 11.5 cm that the tumor invades possibly subserosal fibroadipose tissue. The depth of. invasion is 1.1 cm grossly.. The remaining mucosa shows 3 polyps measuring 0.2 to 2.5 cm in greatest dimension. The attached adipose tissue is. thoroughly examined and all identified lymph nodes are submitted. Representative sections of the specimen are submitted for permanent sections and for TPS. Summary of sections: proximal margin shave D distal margin shave tumor A - appendix representative sections RSC  -representative sections of colon RSI - representative sections of ilium POY - polyps, representatives LP largest polyp, serial sections. LN - lymph nodes BLN - bisected lymph nodes Summary of Sections: Part 1: SP:colon, Right ; resection. Block Sect.  Site PCs 2 21 1 12  LN 24 2 1p 2 1 2 p 1 poy 22 rsc rsi 10 t 10 ** End of Report *
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diff --git a/output/text/7179aa85-2998-4619-9500-8d03e7ecdd53.txt b/output/text/7179aa85-2998-4619-9500-8d03e7ecdd53.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a910c2fc6b4070f0adc08ccbffa1b6eb73070157
--- /dev/null
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+
+--- Page 1 ---
+SPECIMENS: A. PARA-AORTIC LYMPH NODE B. LEFT KIDNEY C. PARA-AORTIC LYMPH NODES SPECIMEN(S): A. PARA-AORTIC LYMPH NODE B. LEFT KIDNEY C. PARA-AORTIC LYMPH NODES INTRAOPERATIVE CONSULTATION DIAGNOSIS:S FSA: Lymph node, paraaortic, biopsy: metastatic carcinoma Diagnosis was called to DIAGNOSIS: A. LYMPH NODES, PARA-AORTIC, EXCISION: - METASTATIC RENAL CELL CARCINOMA (1/1) B. KIDNEY. LEET. RADICAL NEPHRECTOMY: - RENAL CELL CARCINOMA (9.5 CM) INVOLVING SINUS ADIPOSE TISSUE - EXTENSIVE LYMPHOVASCULAR INVOLVEMENT IS IDENTIFIED - ADRENAL GLAND AND MARGINS OF RESECTION ARE UNINVOLVED C. LYMPH NODES. PARA-AORTIC. DISSECTION: - METASTATIC RENAL CELL CARCINOMA INVOLVING SIX LYMPH NODES (6/11) SYNOPTIC REPORT - KIDNEY (PARTIAL OR RADICAL) Specimens Involved Specimens: A: PARA-AORTIC LYMPH NODE B: LEFT KIDNEY C: PARA-AORTIC LYMPH NODES Specimen Type: Radical nephrectomy With adrenal gland Laterality: Left Tumor Site: Middle pole Lower pole Focality: Unifocal Tumor Size (largest tumor if multiple): Greatest dimension: 9.5cm Additional dimensions: 6.5cm x 3.3cm Macroscopic Extent of Tumor: Tumor extension into perinephric tissues WHO CLASSIFICATION The morphology and immunoprofile below best are not entirely specific but best support a diagnosis of. papillary renal carcinoma, type 2. Due to intermediate areas between papillary and clear cell phenotype. a clear papillary renal cell carcinoma was also considered and FlSH for TFE gene rearrangement will be performed to exclude an adult translocation related carcinoma. See addendum report. Histologic Grade (Fuhrman Nuclear Grade): G3: Nuclei very irregular, approximately 20 u; nucleoli large and prominent Invasion of Vascular/Lymphatic: Present Perinephric Tissue Invasion: Present Margins: Margins uninvolved by invasive carcinoma Adrenal Gland: Uninvolved by tumor Regional Lymph Nodes: Positive 7 / 12 Additional Findings: None identified Pathological Staging (pTNM):  pT 3a N 1 M x Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition SUMMARY OF IMMUNOHISTOCHEMISTRY/SPECIAL STAINS Material: Block B4 Population: Tumor Cells
+
+--- Page 2 ---
+Stain/Marker:Result:Comment: CYTOKERATIN 7 Negative EMA NegativeClear cell areas positive CD 10 Positive CYTOKERATIN-HMW-34BE12 Negative RACEMACE Positive PAX-2 Positive P63 Negative HMB 45 Negative A103,MELAN-A  Negative VIMENTIN Positive Focal, weak RENAL CELL Positive CAM 5.2 Positive CYTOKERATIN AE1/3 Positive CD 117-C-KIT Positive The interpretation of the above immunohistochemistry stain or stains is guided by published results in the medical literature, provided package information from the manufacturer and by internal review of staining performance and assay validation within the of the. The use of one or more reagents in the above tests is regulated as an analyte specific reagent (ASR). These tests were developed and their performance characteristic determined by the They have not been cleared or approved by the U.S. Food and Drug Administration.. The FDA has determined that such clearance or approval is not necessary. Special stains and/or immunohistochemical stains were performed with appropriately stained positive and negative controls. GROSS DESCRIPTION: A. PARA-AORTIC LYMPH NODE Received fresh for intraoperative consultation in a container labeled with the patient's name and designated "para aortic lymph node r/o TCC vs. renal cell" is a 3.1 x 2.2 x 1.6 cm firm, pink-tan lymph node. The specimen is inked black and sectioned to show a tan nodular cut surface. Specimen is entirely submitted as follows: A1: frozen section material. A2: remaining lymph node. B. LEFT KIDNEY Received fresh, labeled with the patients name and "left kidney" is an intact kidney with attached perinephric fat measuring 14.9 x 8.3 x 6.2 cm, and weighing 346 grams collectively. The isolated kidney measures 13 x 6.9 x 3.3 cm. Extending from the renal pelvis are a ureter (7 cm in length and 0.3 cm in diameter), renal vein (1.2 cm in length and 0.7 cm in diameter), and renal artery (1.1 cm in diameter and 0.5 cm in diameter). Tumor grossly appears to extend into the ureter and but is not present at the resection margin. There is a 9.5 x 6.5 x 3.3 cm poorly circumscribed, solid to partially cystic, variegated mass with hemorrhage and necrosis in the lower pole involving the cortex, medulla and invading into the renal pelvis. It is adjacent to the renal hilum. The mass grossly appears to invade perinephric fat. The uninvolved renal parenchyma is tan-brown with a well-defined cortico-medullary junction. There is a 4 x 2 x 0.4 cm adrenal gland without focal lesions. No lymph nodes or stones are identified. Gross photographs are taken. Representative sections are submitted as follows:. B1: ureteral margin B2: vascular margins B3-B6: tumor closest to capsule B7-B8: tumor with ureter, shave B9-B10: tumor with ureter
+
+--- Page 3 ---
+B11: tumor and perihilar fat B12: tumor with capsule B13: tumor with peri-peneprhic fat B14: kidney B15: adrenal B16-B20: additional sections, tumor with renal pelvis C. PARAAORTIC LYMPH NODES Received fresh in a container labeled with the patient's name and designated "paraaortic lymph nodes' is a 7 x 5.5 x 3.2 cm aggregate of red, firm tissue. On section, multiple lymph nodes are identified ranging from 0.2 x 0.2 x 0.1 cm to 5.1 x 3.5 x 2.2 cm. The cut surfaces of the largest lymph nodes are tan and firm. The specimen is submitted as follows: C1-C5: representative sections, largest lymph node C6-C8: representative sections, 3 cm lymph node C9: matted lymph nodes, bisected C10: matted lymph nodes, bisected C11: 4 possible lymph nodes C12: 4 possible lymph nodes CLINICAL HISTORY: None given PRE-OPERATIVE DIAGNOSIS: Left renal mass ADDENDUM: ASPsCR1-TFE3 Dual Color, Dual Fusion Translocation Probe Case No Outside Case No NA Pathologist Analytical Interpretation of Results: ASPSCR1/TFE3 translocation negative Clinical Interpretation of Results: Translocation involving ASPSCR1 (also known as ASPL) at 17q25 to the transcription factor TFE3 at Xp11.1 was evaluated with interphase fluorescence in situ hybridization (FISH) on formalin-fixed paraffin embedded tissue sections using a proprietary probe set labeled in the  Fusion signals of the ASPSCR1 locus and the TFE3 locus were not identified in this specimen. These. results do not exclude a TFE3 translocation in this tumor as such tumors in the kidney can. have multiple fusion partners. Source of case Block used NA Tissue fixation formalin-fixed tissue Tissue source  kidney Limitations ANALYTE SPECIFIC REAGENT: The use of one or more reagents in the above tests is regulated as an analyte specific reagent (ASR). These tests were developed and their performance characteristics determined by the the. They have not been cleared by the US Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. Overview of this test The ASPSCR1-TFE3 Dual Color, Dual Fusion Translocation Probe is designed to detect the juxtaposition of ASPSCR1 (also known as ASPL) to the transcription factor TFE3. Translocation of. ASPSCR1 (also known as ASPL) to the transcription factor TFE3, der(17)t(X;17)(p11.2;q25), is characteristic of alveolar soft part sarcoma (ASPS) and present in the majority of cases. The ASPSCR1 PDGFB Dual Color, Dual Fusion Translocation Probe is a mixture of the ASPSCR1 probe (BAC clones RP11-756O14, RP11-455O6 and RP11-428B22 centromeric of ASPSCR1) labeled with SpectrumGreen and the TFE3 probe labeled with SpectrumOrange (BAC clones RP11-552E4, RP11-344N17 and RP11-753G22 telomeric of TFE3). The expected pattern in a normal nucleus hybridized with the ASPSCR1-TFE3 probe is the two orange, two green signal pattern. In a nucleus. harboring the der(17)t(X;17)(p11.2;q25), the most common pattern is one orange signal, one green signal, and one orange/green (yellow) fusion signals resulting from the reciprocal translocation.
+
+--- Page 4 ---
+ This probe was labeled in the according to the method of and  its use is regulated as an ASR R. Detection of the ASPSCR1-TFE3 gene fusion in paraffin-embedded alveolar soft part sarcomas. Results interpreted  yes Gross Dictation:.,, Microscopic/Diagnostic Dictation.., Final Review:., PATHOLOGIST, Final Review: PATHOLOGIST, Final: PATHOLOGIST, Addendum:., Pathologist, Addendum Final.:., Pathologist,
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diff --git a/output/text/7187a1e1-7da1-46ab-9eb3-682fe353617c.txt b/output/text/7187a1e1-7da1-46ab-9eb3-682fe353617c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2891055398ef622773879a0c7563a09d23b16732
--- /dev/null
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+
+--- Page 1 ---
+UUID: ECC9EDD8-CE51-49B8-9B3A-52D69920080F0 Page 1 of 5 TCGA-YZ-A984-01A-PR Redacted Facility  Name Result Information Status Provider Status Edited :. Ordered Observation Date and Time Entry Date Result Narrative (NOTE) Surgical Pathology Report. Patient Name: Accession #: Med. Rec #: Submitting Physician:. tCDb 3 -- Clinical History Melanoma left eye. celL migeol'877t/3 Sit OCowoL Cb9.3 ADDENDA: Addendum added: J 3/12/14 --Final Pathologic Diagnosis--- A. Left eye, enucleation:. - Malignant melanoma, mixed with predominantly spindle cell type. B. Vortex vein, left eye, biopsy:. No evidence of malignant melanoma.. All controls show appropriate reactivity. The immunohistochemical and/or in situ hybridization tests reported here, except for those addressing HER-2/neu overexpression, have been developed and their performance characteristics determined by the at the and are not required to. have nor do they have FDA approval.. --Electronically Signed by--- --Addendum Report- Page 1 of 5
+
+--- Page 2 ---
+Page 2 of 5 Addendum Status: Signed Out Unchanged. Microscopic examination was performed on H&E and pAs stained sections. Cytogenetics Report: Status: Signed Out Cytogenetics Case Number: Karyotype: 46,xx,t(3;6)(q27;q15)[4]/46,xx{16] Interpretation: This is a tumor from the left eye of a patient with ocular melanoma. Cytogenetic analysis of this sample shows an abnormal clone of cells with a translocation between chromosomes 3 and 6. The most common recurring abnormalities seen in uveal melanomas are nonrandom changes of chromosomes 1, 3, 6 and 8. More specifically, deletions of 1p, monosomy for chromosome 3, gains of 6p, losses of 6q, and i(8q). Structural rearrangements of chromosomes 3 are rare in uveal melanomas, most often seen with unbalanced translocations resulting in deletions of 3q. The significance of the. rearrangement of chromosomes 3 and 6 in this sample is not known.. Ref: K. Sisley "Tumors of the Eye", in Cancer Cytogenetics, 3rd Edition, S Heim & F Mitelman eds, wiley-Blackwell, 2009, 62l-640. ***Electronically Signed Out By*** MD --MICROSCOPIC: - Specimen A shows sections of a globe with a large choroidal tumor (l.5cm diameter and 1.4 cm height) composed predominantly of a cohesive spindle cell proliferation. Focal areas with cells having an epithelioid appearance are also noted. Mitotic figures are rare. The tumor is partially pigmented.The ciliary body is not involved by the tumor. Also, scleral or extrascleral extension is not identified. The optic nerve is not observed Page 2 of 5
+
+--- Page 3 ---
+Page 3 ot 5 on the sections taken. These findings are consistent with a spindle cell malignant melanoma arising from the choroid. Specimen B shows a vascular channel not involved by malignant melanoma. --SPECIMEN(S) RECEIVED:- A: Eye, enucleation B: Neuropathology, BX, NOs ---GROSS DESCRIPTION:--- The specimens are received in two properly labeled containers with the. patient' s name and accession number. A. The specimen is designated "enucleated left eye" and consists. of a 2.8 x 2.4 x 2.6 cm globe with a clear cornea measuring 1.1 x 1.0 cm in diameter. The optic nerve stump is 0.2 cm in length. The specimen is. trisected revealing a brown-black, partially fragmented mass measuring 1.5 cm in maximum diameter and 1.4 cm in maximum height. The mass is in the inferior aspect of the posterior chamber. RS 2 Summary of Cassettes: Al, lower calotte with tumor; A2, central eye slab B. The specimen is designated "vortex vein left eye" and consists. of a 0.2 x 0.1 x 0.05 cm portion of tan-red soft tissue. TE 1. Lab Use Only: Job ID Gross description by: Patient Release Status: This result is not viewable by the patient. Patient Care Team Notifications End Relationship Specialty Start Family Medicine  Dermatology MD  Medical Oncology DO Surgical Oncology Endocrinology. MD Diabetes & Metabolism OB/GYN Ophthalmology MD Procedures with Linked Chargeables Chargeable CPT Code 88305 18/1 M3
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diff --git a/output/text/7198b086-6d0a-4360-9f2f-772e11318e05.txt b/output/text/7198b086-6d0a-4360-9f2f-772e11318e05.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1ea09ee32310b19857b5d760397d4ac205b1a275
--- /dev/null
+++ b/output/text/7198b086-6d0a-4360-9f2f-772e11318e05.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+TCGA-CM-4747 * Addendun * Clinical Diagnosis & History: uicerated invasiva ileocecal valve,. noduiee ts 7,4B, and 5 measuring 2.2 x1.7, 1 x 1.6 cm, 1.7 cm x 1.3 cm. 1: sp: Right nemicolectomy 2: SP: Small bowel mesenteric lymph node. DIAGNOSIS: LARGE BOWEL. RIGHT HEMICOLECTOMY:  TUMOR TYPE: ADENOCARCINOMA, - HISTOLOGIC GRADE: MODERATELY DIFFERENTIATSDS -TUMOR LOCATION CECUN. -TUNOR SIZE: LENGTH IS 5.5 CH, WIDTH IS 3.5 CM, MAXIMAL THICKNESS IS 3.5CM. GROSS CONFIGURATION: FONGATING. PREEXISTING POLYP (AT THE SITE OF THE CARCINOMA): IDENTIPIED, OF TUBULOVILLOUS ADENOMA HYPE TUMOR INVASION: INVASION THROUCH BOWEL WALL WITH INVOLVEMENT OF 1 SEROSA. GROSS TUMOR PERFORATION: NOT IDBNTIFIED. - SEROSAL INVOLVEMEND: IDENTIPIED.S - VASUULAR INVASION: SUSPICIOUS FOR VASCULAR INVASION. PERINEURAL INVASION: IDENTIFIED. SURGICAL MARGINS (FOR COLONIC TOMORS): FREE OF TUMOR - POLYPS (AWAX FROM THE CARCINOMA): NOT IDENTIFIED. -NON-NEOPLASTIC BOWEL: DIVERTICULA DISRASE. THE PATHOLOGIC STAGR IS ): pT4. LYMPH NODESNUMBER WITH METASTASES2,NUMBER EXAMINED29 -THE PATHOLOGIC STAGE IS DNI. LYMPH NODE, SMALL BOWEL MESENTERY; RXCISIONt . ONE BENIGN LYMPH NODE (O/1). I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED DPON MY PERSONAL BXAMINATION OF THE SLIDES (AND/OR OTHER'MATERIAL), AND THAT I HAVE REVIEWED AND APDROVED THIS REPORT. Continued on next page
+
+--- Page 2 ---
+Page 2 of 3 1) The specimen is received fresh, labeled "Right hemicolectomy" and consiots of a segment of texminal ileum, cecun with attached appendix and. ascending colon. The terminal ileum measures 24 om in length and 5 om in ciroumference at the proximal reseoted margin. The xemaining colon measures 29 cm in length with a cixcunference of 6 cm at the distal resected margin. The attaohed appendix meaaures 5 cm in length and averages 0.6 an in diameter. The appendiceal and intestinal seroaa is pink tan and amooth. Focally hemorrhagic lobulated yellow tan adipose tisaue spans the length of the specimen measuring up to 4 cm in thickness. The aexosa is inked black. The specimen contains a fungating masa (5.5 cm in length and 3.5 dm in width) occupying the cedwn, surrounding the ileocecal valve with sparing of the appendical orifice. Sectioning shows that the tumor invades into the subserosa. The depth of Invasion is 3.5 cn grossly. The xemaining colonia. mucosa shows rare diverticula. The distal ileal mucosa shows occasional. diverticula and small mucosal polyps. The specimen is aubmitted fox Iymph. node disseotion. Representative sections of the specimen are submitted for. pexmanent seations. Sumaxy of sections: p-. proximal maxgin shave. D -- diatal margin shave. Mmasa D deepest extent of mass appendix xepxesentative seations  ileal mucosa with polyps C--representative sections,. colon LN-- lymph nodes 2) The specimen is received in formalin, labeled "Small bowel mesenteric lymph node" and consiste of a 2.3 x 1.6 x 0.4 om, firm, fatty, tan-red Lyoph node, whioh is bisected to reveal smooth, foually hemorrhagic, tan-pink cut Sumnary of sectione: BLN -- bisected lymph nodes. Sumary of Sestions! Paxt 1: SP: Right bemicolectomy BlOCk Sect. Site PCg A 1 Continued on next page *.
+
+--- Page 3 ---
+Pago 3 of 3 1 1 N 6+ H 3 2 24 4 1 Paxt ?1 Se: Small bowel mesenteric lymph node. Block Sect. Site PC8 BLN 2 2 #1) SITE: LARGE BOWEL - IMMUNOHISTOCHEMICAL STAINING FOR DNA MISMATCH REPAIR PROTEINS HAS BEEN PERFORMED. THE RESULTS ARE AS FOLLOWS: MLHI; STAINING PRESENT IN TUMOR MSH2 : STAINING PRESENT IN TOMOR MSH6: STAINING PRESENT IN TUMOR PMS2 1 STAINING PRESENT IN TOMOR CONCLUSION: IMMUNOHISTOCHEMICAL STAINING FOR THE TESTED DNA MISMATCH REPAIR PROTEINS IS RETAINED IN THE TUMOR. Some of the immunohistochemlstry and Ish tests wexe developed and their performanca characteriatica were determined by the Department of Pathology. They have not been cleared ox appxoved by the us Food and Drug Administration. The rDA has determined that such clearance or approval is not necessary. These tests.are used for clinical purposes. They should not be regarde tigational or for xesoarch. Tbis laboxatoxy ie ceztified ag undex the qualified to pexform high complexity. ** End of Report **
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diff --git a/output/text/719a7457-08f6-4699-9537-8118c1fd5304.txt b/output/text/719a7457-08f6-4699-9537-8118c1fd5304.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2387960397973ae61e5247779b19599577ce5231
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+
+--- Page 1 ---
+UID:BE3CE26C-C3EC-442E-A618-BB6DEC18C2E7 TCGA-WC-A87Y-01A-PR Redac1 Specimen Date/Time: DIAGNOSIS 1-30%) (s1-90%) (A) RIGHT GLOBE, ENUCLEATION: CHOROIDAL MELANOMA, MIXED EPITHELIOID AND SPINDLED TYPE, 13 MM BASE VORTEX VEIN INVASION PRESENT TUMOR EXTENDS EXTRAOCULARLY IN VORTEX VEIN (A2) Optic nerve negative for tumor. Melansma ejitklixel i ayeindle Ciliary body negative for tumor. aeQL miyeeL' 877vh3 See comment. COMMENT s11/4 The tumor is mitotically active at 1 per 10 high-power fields. The PAS is examined for intraocular structures. GROSS DESCRIPTION (A) RIGHT GLOBE - An intact globe (22 x 22 x 21 mm) has an intact 4.0 mm optic nerve. The anterior chamber is formed gray iris (10 x 11 mm) surrounding a round 6.0 mm pupil. The sclera is unremarkable. By transillumination a shadow is pres from 1-3 o'clock present 6.0 mm from the optic nerve and 2.0 mm from the limbus. The shadow corresponds to a choroidal brown tumor with 13 mm base and 7.0 mm height. The vitreous is clear. The sclera beneath the tumor is grossly intact. SECTiON CODE: A1-A4, vortex vein and tissue in regions (superior temporal, superior nasal, inferior nasal, inferior temporal); A5, pupil-optic nerve section; A6 calotte with tumor; A7, additional calotte; A8, optic nerve margin and lens. CLINICAL HISTORy Melanoma SNOMED CODES T-AA000,M-87203 "Some tests reported here may have been developed and perdormance characteristics determined by. These tests have not specitically cleared or approved by the U.S. Food and Drug Administration." Entire report and diagnosis completed by: -END Of rEpOrt.
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diff --git a/output/text/71ebcede-d8f9-4ee0-8b06-a6478d8c27ce.txt b/output/text/71ebcede-d8f9-4ee0-8b06-a6478d8c27ce.txt
new file mode 100644
index 0000000000000000000000000000000000000000..11454f52ea13c9acee59e136f3c09bca9179e3b3
--- /dev/null
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+
+--- Page 1 ---
+TCGA-A6-2670 SPECIMEN A. Sigmoid colon B. Appendix CLINICAL NOTES PRE-op DiAgnosis: Diverticulitis, carcinoma sigmoid colon, small. walled-off perforation.. GROSS DESCRIPTION A.  Received fresh, subsequently fixed in formalin. labeled "sigmoid colon" is a 21 cm. long portion of colon which is stapled at one end (inked blue) and opened at the opposite end (inked black). The serosa of the specimen is pink-tan smooth glistening and predominantly covered with abundant yellow lobular fat. The specimen shows a 4.5 x 3.5 x 0.7 cm. portion of fibrous tissue which is slightly hemorrhagic and shows multiple adhesions. This is located 6.5 cm. from the inked luminal margin (inked blue). The specimen is opened to show a pink-tan smooth glistening mucosa with normal folds having a 4.7 x 2.7 x 0.5 cm. tumor which is centrally located. The cut surface of the tumor shows invasion into the muscularis propria and into the fat, coming within 11 cm. of the radial margin. The mucosa is pink-tan smooth glistening with normal to slightly dilated folds having an average circumference of 6.0 cm. The remainder of the specimen is sectioned to show a few diverticula grossly identified. This is located adjacent to the tumor. No perforations are grossly identified in the area of the adhesions. Lymph nodes are grossly identified in the fat. Representative. sections of the specimen are submitted as follows:. BLOck suMMARy: 1 - representative luminal margins; 2 - possible representative diverticula; 3 and 4 - representative section of hemorrhagic adhesions and possible walled off perforation; 5-7 representative section of tumor including tumor to normal and tumor to fat; 8 - representative radial margin; 9 - 9 possible lymph GROSS DESCRIPTION nodes; 10 9 possible lymph nodes; 11 - 3 possible lymph nodes. RS-11 Please note specimen was submitted for tissue procurement. B. Appendix specimen consist of a 6.0 x 0.7 cm. grossly. unremarkable appendix which is partially covered in pink. tan smooth glistening serosa and yellow lobular fat. The specimen is sectioned to show an intact wall an average thickness of 0.3 cm. The specimen lumen ranges from pinpoint to 0.3 cm. partially filled with green feces. No discrete gross lesions are identified. Representative sections of the specimen are submitted in one cassette with the proximal endings. RS1.
+
+--- Page 2 ---
+MICROSCOPIC DESCRIPTION Microscopic sections reveal the presence of an area of. granulation tissue with foreign body reaction present in. the serosal fat. This is immediately adjacent the invasive carcinoma. It may represent reaction to ruptured acute. diverticulitis. There is no residual diverticulum present to substantiate that source. Alternately, the changes might be. secondary to perforation of the carcinoma into the free serosal Surface. Histologic type: Adenocarcinoma.. Histologic grade: Moderately differentiated.. Primary tumor (pT): Tumor invades through the wall of the colon into the serosal fat (pr3).. Proximal margin: Negative. Distal margin: Negative. Circumferential (radial) margin: Negative.. Vascular invasion: Negative. MICROSCOPIC DESCRIPTION Regional lymph nodes (pN): 22 mesenteric lymph nodes are free of. metastatic carcinoma (0/22) (pN0). Non-lymph node pericolonic tumor: Absent.. Distant metastasis (pm): Can not be assessed (pmx).. Other findings: Old abscess site, serosal fat (see above). Appendix. without significant histopathologic finding.. 5, 1 DIAGNOSIS A. Colon, sigmoid, segmental resection: Invasive moderately differentiated colonic adenocarcinoma extending into the serosal fat.. Proximal, distal and radial margins of resection are free of tumor. 22 mesenteric lymph nodes negative for metastatic carcinoma (0/22). Pericolonic focus of foreign body reaction,. granulation tissue and chronic inflammation (see microscopic description). B. Appendix, incidental appendectomy:. No significant histopathologic findings.
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diff --git a/output/text/71f2cf5d-73a1-42e6-8950-0d0ce1d0acb3.txt b/output/text/71f2cf5d-73a1-42e6-8950-0d0ce1d0acb3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..385bab8b104212ebe71ab86e4fa4ad5f54df3b7b
--- /dev/null
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+--- Page 1 ---
+CGA-A6-3810 SPECIMEN A. Sigmoid colon - stitch on distal and staple line at proximal end B. Proximal margin of sigmoid colon CLINICAL NOTES PRE-OP DIAGNOsIS: Left colon cancer. GROSS DESCRIPTION A. The specimen is received unfixed, labeled "sigmoid. colon", and consists of a segment of large bowel, measuring 20 cm. in length and 2.8 cm. in diameter. There is abundant pericolonic fat and the entire specimen is up to 10 cm. in diameter. There is a suture at the open end of the specimen, the opposite end is stapled. There is an area of narrowing where an appendix. epiploica is adherent to the serosal surface of the colon. This area is 6 cm. from the open end. The bowel is opened with a single incision on the antimesenteric surface. There is a napkin ring- like fungating mucosal tumor, measuring 6 cm. in length and 1.2 cm. in depth. The tumor is circumferential. It is 6 cm. from the distal margin of resection and approximately 1l cm. from the proximal margin. Sections after fixation and clearing. A portion of the specimen is taken for research purposes. The fat is dissected off the colon and there is an area that probably represents pericolonic abscess immediately adjacent to the tumor. This area might be. associated with diverticulum. MLM:men Block summary: 1, 2 margins of resection; 3 - 7 tumor; A. 10-22. pericolonic lymph nodes. B. The specimen is received unfixed labeled "proximal. margin of sigmoid colon" and consists of a piece of white. and yellow soft tissue with stapes in it. The specimen measures 4 1 x 0.4 cm. RS-1.
+
+--- Page 2 ---
+MICROSCOPIC DESCRIPTION A. Tumor type: Colonic adenocarcinoma. Tumor grade: 2 out of 3 Tumor size: 6 cm Distance to nearest margin: 6 cm Level of penetration: Carcinoma penetrates into pericolonic fat. Margins of resection: Negative for malignancy Vascular invasion: Absent Host response: Marked acute and chronic inflammation. One area resembles a diverticulum with pericolonic abscess, diverticulum destruction and carcinoma (block A7) Attached lymph nodes: There is no evidence of malignancy in any of 30 lymph nodes. Non-lymph node pericolonic tumor:. Absent pTNM Stage: T3 NO B.  Negative for malignancy 5, 3 DIAGNOSIS A. Sigmoid colon, segmental resection: Moderately differentiated colonic adenocarcinoma Note: Carcinoma invades through the muscularis propria into pericolonic soft tissue. There is no evidence of malignancy in any of 30 pericolonic lymph nodes. B.  Sigmoid colon, proximal margin, biopsy: Negative for malignancy
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diff --git a/output/text/71f7de37-5f8d-42d3-8756-7e8083332533.txt b/output/text/71f7de37-5f8d-42d3-8756-7e8083332533.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d24e2a868911c7b9da1cd166fcc7786be00a256c
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+
+--- Page 1 ---
+FINAL SURGICAL PATHOLOGY REPORT Diagnosis: A.-B.) RIGHT RENAL MASS AND BASE OF TUMOR, PARTIAL NEPHRECTOMY: -PAPILLARY RENAL CELLCARCINOMA, TYPE 2. - Fuhrman nuclear grade 2. - Size: 1.6 cm. -Confined to the kidney. - Negative for extracapsular invasion into fat. -Negative for lymphovascular invasion. - BASE (margin) OF TUMOR NEGATIVE FOR MALIGNANCY. COMMENT:
+
+--- Page 2 ---
+Procedure: Partial nephrectomy. Specimen type:  Renal mass and base of tumor.. Right. Specimen laterality: Tumor Features: Tumor size: 1.6 cm. Tumor focality: Single focus. Histologic type: Papillary renal cell carcinoma, type 2 Histologic grade (Fuhrman nuclear grade): 2, moderately differentiated. Sarcomatoid features: Not present Macroscopic extent of tumor: Confined to the renal cortex. Microscopic tumor extension: Confined to the renal cortex. Lymph Nodes Not evaluated. Margin: Base of tumor negative. Tumor clear of inked base of the initial excision by at least 2 mm Pathologic tumor staging descriptors: Primary tumor (pT): pT1a. Regional Lymph nodes (pN) pNX. Distant metastasis (pM): pMX. Margin status (R): RO. Pathologic stage: 1. Pathologic findings in non-neoplastic kidney: None. Additional pathologic findings: None. Comment: Source of Specimen: A.Mass;Right renal B. Renal cell base of tumor Intraoperative Diagnosis: B.FsB: Kidney,rightbase of tumor,biopsy:Benign kidney tissue,no tumor present
+
+--- Page 3 ---
+FINAL SURGICAL PATHOLOGY REPORT Gross Description: A. Part A designated right renal mass. Initially received in a fresh state for frozen section analysis are three portions of soft tissue, including two pieces of perinephric fat and a excision of kidney.The portion of kidney is a corked-out wedge of tissue weighing 3 grams and 2.1 x 1.7 x 1.4 cm. The apparent deep surgical margins are now marked blue, and the superficial surface is marked yellow.The specimen is serially sectioned to reveal a well circumscribed, softened hemorrhagic tumor mass measuring up to 1.6 cm in greatest dimension.Due to the softened hemorrhagic state of the lesion the relationship with the surrounding thin border of renal parenchyma is difficult to discern, however the lesion demonstrates a capsular appearance. A discrete representative portion is retrieved centrally from the lesion and submitted for Oncogenotyping studies. The kidney biopsy is entirely submitted for microscopic evaluation.The two portions of accompanying fat are examined, and both pieces demonstrate an area of indentation, possibly corresponding to the fat formerly overlying the mass, and the fat demonstrates a thickness range of 1.5- 2.3 cm to the radial surface. Sectioning through the fat demonstrates glistening yellow-tan lobular surface without gross evidence of an invasive component.Representative sections are submitted for microscopic evaluation. Cassette summary:A1-A4) kidney biopsy, sequentially submitted, A5-A7) fat overlying lesion represented B. Received fresh labeled with the patient's name and "renal cell base of tumor" and consists of a tan portion of tissue measuring 0.7 x 0.5 x 0.1 cm.The specimen is entirely submitted for frozen section analysis in FsB.The tissue is submitted for permanent sections in cassette B1 Microscopic Description: A. - B.) Sections of the initial mass excision show a well-encapsulated neoplasm with a complete fibrous capsule. The tumor has a papillary and tubular architecture and the cells range from small to intermediate with round to oval nuclei and small central nucleoli not visualized at 10x (Fuhrman nuclear grade 2). There is abundant acidophilic cytoplasm throughout the majority of the tumor consistent with the type 2 subtype of papillary Rcc.Characteristic foamy macrophages are present. The tumor is confined within the renal cortex without invasion through the capsule or invasion into the attached adipose tissue.The inked base of the tumor and the separate specimen designated base of tumor consists of benign renal parenchyma without tumor involvement. Immunohistochemistry performed shows the tumor is strongly positive for cytokeratin 7 and Vimentin. CD10 is positive in approximately 30-40% of the tumor. There is only focal and weak positivity with RCC immunohistochemistry.Ber-EP4 and C-Kit are considered negative.
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diff --git a/output/text/71fe1cf3-cd1d-41a2-b2e4-70ec905643d5.txt b/output/text/71fe1cf3-cd1d-41a2-b2e4-70ec905643d5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9f36aa5d557aa91de04bd13167d4723c87c631d4
--- /dev/null
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+
+--- Page 1 ---
+Surgical Pathology Report Name: Case #: DOB: Collected: Gender: Received: MRN: Reported: Location: Copy To: Physician: Pathologic Interpretation: 1cs-0-3 A. Sentinel node #1 -One lymph node, no malignancy seen (0/1). - immunostains are in progress. Srte: breast, Nos c 50.9 8. Sentinel node #2 -One lymph node, no malignancy seen (0/1). - Immunostains are in progress. c. Sentinel node #3d UUID:7C003A4F-DC30-43D0-AC61-ACE6BA118BEE TCGA-EW-A1IY-01A-PR Redacted -One lymph node, no mallgnancy seen (0/1). - Immunostains are in progress. D. Non-sentinel lymph node: - Two lymph nodes, no malignancy seen (0/2). E. Right breast mass, 1 short stitch superior, 1 iong stitch lateral, lumpectomy:. - Innitrating ductal carcinoma, intermediate nuclear grade, 2.0 cm in greatest dimension.. - Focat ductal carcinoma in situ, cribriform type, intermediate nuclear grade with necrosis.. - Margins are free of tumor. - Lymphovascular invasion is not seen. - AJCC pT2N0Mx - See tumor summary. - Other areas of the breast show fibrocystic changes with microcalcifications.. - Skin with scar and foreign material (gel foam) deposition. - Changes of [previous biopsy site. - Focal changes of previous therapy effect noted on non-neoplastic breast tissue and a small portion of tunsor. - Immunostains are in progress. F. Deep margin blue true deep: -- Skeletal muscle, no malignancy seen. G. Internal mammary sentinel node -- , 2nd intercostal - One (ymph node, no malignancy seen (0/1). : - Immunostains are in progress. Tumor $ummary. Speclmen Type: Excision Lymph Node Sampllng: Sentinel lymph nodes and one non-sentinel node Specimen Slze: Greatest dimension: 7.2 cm Additional dimonslons: 6.1 x 2.5 cm Laterallty: Right Tumor Site: Not specified Slze of Invasive Component: Greatest dimension: 2.0 cm Additional dimensions: 1.8 x 1.5 cm Histologlc Type: Invasive ductal carcinoma Histologlc Grade: Tubule Formatlon: Moderate 10% to 75% (score = 2) Nuclear Pleomorphism: Marked variation in size, nucleoli, chromatin clumping, etc (score =3) For a 40x objactlve with a flold area of 0.152 mm2: 0 to 5 mitoses per 10 HPF (score =1) Total Nottingham Score: Grade II: 6-7 points Pathologic Staging (pTNM) Primary Tumor: pT2d
+
+--- Page 2 ---
+SURGICAL PATHOL Report Regionai Lymph Nodes: pN0 Number examined: 6 Number involved: 0 Distant Metastasis: pMX Margins: Uninvoived by invasive carcinoma Distance from closest margin: 2.0 mm Specify which margin: Posterior (deep), see comment. Venous/Lymphatic Invasion: Absent Microcalcificatlons: Present in non-neoplastic tissue ***Electronically Signed Out By*. NOTE: Some inmunohistochamicei antibodies wre anatyte apecfic reegents (ASRs) yalidatec by our iaboraiory (tHier ? Parvo, H. pytori, HBcore). Thess ASRs are ctinicaty uprud indicaiors thet d not r*qurs FDA appr0vaj. The3 conssa usd: IO5=ER, PgR 636=PR, A485=HER2. H-11=EGFR, CCH2/DDG9=CMV, F39.4.1=AR and HPV by ISH. AW Wmm with formahn or molecuiar fxed. paraffin embedded tisaue. Detection is by L SA8. The resu read by a pathologist as postive or negative.. As the atrending pethologiet, I attest that i: () Examind the relevantd preparaton(s) For the specimen(s); and (i0 Rendered e dtagnozis(es). Procedures/Addenda Date Ordered: Status: Signed Out Addendum Date Complete: Date Reported: : Addondum Dlagnosis A, B, C, G. !mmunohistochemistry for keratin is negative (Blocks A1, A2, B1, B2, C1 and G1). E. Tumor cells are posltive for ER and PR and negative for HER2-neu (block E7). Intraoperatlve Consultation AFS. Sentinel node #1 touch prep and FS: Negative for tumor BFS. Sentinel node #2 FS: Negative for tumor CFS. Sentinel node #3 FS: Negative for tumor FFS. Doep margin blue true deep FS: Skeletal muscle, no malignancy seen. Clinical History: Patient is a . year old female with history of right breast cancer.. Pro Operatlvo Diagnosis: Page 2 of 4
+
+--- Page 3 ---
+SURGICAL PATHOL Report Right breast cancer Specimen(s) Received: A: sentinel node #1 touch prep and FS B: sentinel node #2 i FS C: sentinel node #3 . FS D: non-sentinel lymph node E: right breast mass, 1 short stitch superior, 1 long stitch lateral fresh F: deep margin blue true deep FS G: Internal mammary sentinel node , 2nd intercostal c Gross Description: A. Received fresh and labeled *sentinel node #1 :. touch prep and FS* conslsts of a lymph node, 1.5 cm in|greatest dimension. Specimen bisected and submitted in toto in two cassettes as follows.. 1 Half on lymph node for frozen 2 The rest of lymph node for permanent. B. Received fresh and labeled *sentinel node #2 . consists of irregular shaped. yellow-tan, adipose tissub fragment, 1.4 x 0.7 x 0.2 cm. Specimen submitted in toto in two cassettes. 1 One section from frozen 2 The reminder of the specimen for permanent c. Received fresh and labeled *sentinel node #3. consists of irregular shaped, pale-tan, soft tissue fragrnent, 0.4 x 0.3. x 0.2 cm. Specimen bisected and submitted in toto in one cassette for frozen.. D. Received in formalin and labeled *non-sentinel lymph node" consists of two irregular shaped. yellow-tan, sot tissue. fragment, 1.4 x 0.8 x 0.3 cm and 1.0 x 0.5 x 0.2 cm. Examination of the specimen reveal two possible lymph nodes, 1.3 cm and 0.8 cm in greatest dimension. Specimen submitted in toto in two cassettes as follows. 1 Large lymph node bisected 2 Small lymph noe bisected E. Received fresh and labeled "right breast mass, 1 short stitch superior, 1 long stitch lateral" consists of an irregular by shaped, nbro-adipose tissue fragments measuring 7.2 x 6.1 x 2.5 cm and weighing 35.3 grams. Attached td the anterior. aspect of the specimen there is a very thin ellipse of skin, 2.8 cm by 0.2 cm. For gross purpose the specimeh is inked as follows: Anterior resection the skin surrounding the skin in yellow, superlor resection margin is inked blue, inferior. resection margin is inked green, medial resoction margin is inked red, lateral resection margin is inked orange and posterior resection margin is inked black. Mutiple cross sections reveal an ill-circumscribod, gray-white, harg and gritty mass, 2.0 x 1.8 x 1.5 cm. The mass is 0.2 cm from deep resection margin (nearest margin). 1.5 cm from the|skin surface, 1.0 cm from medial resection margin, 1.7 cm from lateral resection margin, 2.0 cm from superlor resection argin and 1.8 cm from inferior resection margin. The reminder of the specimen reveals an unremarkable fibro-adipose tissue. The stroma to fat ratio is 30.70%. Representative sections are submitted as follows.. 1 Superior resection margin 2 Inferior resection margin 3  Medial resection margln 4 Lateral resection margin 5&6 Composed sections of the mass in relation with deep resection margin (nearest margln) 7-9 Additional representative section from the mass. 10  Representative section from skin 11-14 Representative section from the reminder of the stroma F. Received fresh and labeled *deep margin blue true deep" consists of irregular shaped, yellow-tan, fibro-adipqse tissue fragments, 1.8 x 1.5 x 0.2 cm. The resection margin inked black. Specimen multisected and submitted in totg in one. cassette for frozen. G. Received in formalin and labeled "internal mammary sentinel node , 2nd intercostal  ' consists ofrregular shaped, yellow-tan, soft tissue fragment, 0.5 x 0.4 x 0.1 cm. Specimen submitted in toto in one cassette.  Page 3 of 4
+
+--- Page 4 ---
+SURGICAL PATHOL Report ICD-8(S): 174.8 Page 4 of 4
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diff --git a/output/text/72139a66-d5ae-4a09-a69e-63eb6a7c3f4d.txt b/output/text/72139a66-d5ae-4a09-a69e-63eb6a7c3f4d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..21712e45d9a39e4579bea0e4d0e5e3975cb6da3b
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+/cs-0-3 cacinomn irfi/traty ducth! Nes 8500 Sih: brast, nos cso.9 (A) RIGHT BREAST, NEEDLE-LOCALIZED SEGMENTAL MASTECTOMY: INVASIVE DUCTAL CARCINOMA WITH CENTRAL SCLEROSIS, INTERMEDIATE NUCLEAR GRADE, NOT TINGHAM HISTOLOGIC GRADE 2. (SEE COMMENT) INVASIVE CARCINOMA MEASURES 1.8 CM IN THE LARGEST DIMENSION. LYMPHOVASCULAR INVASION PRESENT. INVASIVE TUMOR EXTENDS TO LESS THAN 1 MM FROM ANTERIOR MARGIN AND TO 5 MM FROM DEEP MARGIN (NOT FINAL MARGiNS, SEE COMMENT). Focal adjacent atypical ductal hyperplasia.. Atypical lobular hyperplasia. Columnar cell change. (B) RIGHT AXILLARY CONTENTS, DISSECTION: METASTATIC CARCINOMA IN ONE OF TWELVE LYMPH NODES (1/12); LARGEST METASTASIS MEASURES 2.0 CM; NO EXTRANODAL EXTENSION IDENTIFIED. (C) RIGHT AXILLARY LEVEL II LYMPH NODES, EXCISION: Nine lymph nodes, no tumor present (0/9).. (D) RIGHT BREAST, NEW SUPERIOR SUPERFICIAL MARGIN, EXCISION: Benign breast tissue (predominantly tibroadipose tissue), no tumor present. (E) RIGHT BREAST, NEW INFERIOR SUPERFICIAL MARGIN, EXCISION: Benign breast tissue, no tumor present.. (F) RiGht BREAST, nEW InfERiOR SUpERFiCiaL mARGin, EXCiSiON: Fibroadipose tissue, no tumor present. (G) RIGHT BREAST, NEW LATERAL SUPERFICIAL MARGIN, EXCISION: Benign breast tissue, no tumor present. Entire report and diagnosis completed by *s. COMMENT Although the tumor has central sclerosis, this comprises less than 30% of the tumor (so the tumor does not qualify as the subtype ot invasive carcinomas with a "large central acellular zone"). Although tumor approached the anterior margin in the initial segmental mastectomy specimen, this tissue was re-excised and found to be tree of tumor, so tumor does not approach the final. surgical margins. Tumor is 5 mm from nearest deep margin. Tumor marker studies were reported previously (see GROSS DESCRIPTION (A) RIGHT SEGMENTAL MASTECTOMY - An oriented segmental mastectomy specimen (5.5 x 5.1 x 3.3 cm). Nine slices are cut from superior to inferior, and a specimen radiograph is obtained. There is a well-circumcised tan-pink mass (1.8 x 1.5 x 0.9 cm) located less than 0.1 cm from the anterior margin and 0.4 cm from the deep margin. On the medial side of the mass there is a fibrotic area measuring 2.0 x 2.0 x 3.5 cm. The entire mass and entire fibrotic area is submitted. INK coDE: Green - interior; blue - superior; black - deep; yellow - superticial; red - medial and lateral. UUID:48CB0118-074A-424B-82D2-E8A2397CF02E Redacted TCGA-GM-A2DC-01A-PR
+
+--- Page 2 ---
+SECTiON CODE: A1, inferior margin, perpendicular; A2, superior margin, perpendicular; A3-A8, tumor entirely submitted; A9, A10, remainder of slice 6; A11-A22, entire tibrotic area from medial aspect of specimen.. (B) AXiLLARY CONTENTS, RIGHT - A non-oriented irregular portion of adipose tissue (13.0 x 5.0 x 0.8 cm). The specimen is seriaily sectioned, and eleven lymph nodes are identified ranging from 0.2 x 0.2 x 0.2 cm to 2.0 x 1.5 x 1.0 cm. SECTION CODE: B1, two lymph nodes; B2, three lymph nodes; B3, two lymph nodes; B4, one lymph node: B5, one lymph node; B6, 37, one lymph node bisected; 88, B9, one lymph node bisected. (C) RIGHT AXILLARY LEVEL II - An irregular portion ot adipose tissue (4.0 x 2.0 x 0.4 cm). The specimen is serially sectioned, and six lymph nodes are identified ranging from 0.2 x 0.2 x 0.2 to 1.5 x 0.8 x 0.7 cm. SECTiON CODE: C1, two lymph nodes; C2, two lymph nodes; C3, two lymph nodes. (D) NEW SUPERIOR SUPERFICIAL MARGIN - A portion ot fibroadipose tissue, 7.0 x 3.0 x 1.2 cm, with clips on the true margin. The true margin is inked black. The specimen is serially sectioned and entirely submitted in D1-D7. (E) NEW INFERiOR SUPERFICIAL MARGIN - A portion of fibroadipose tissue, 4.0 x 4.0 x 1.0 cm, with clips on the true margin. The true marain is inked black. The specimen is serially sectioned ad entirely submitted in E1-E4. ! (F) NEW INFERIOR SUPERFICIAL MARGIN - A portion of fibroadipose tissue, 2.5 x 2.5 x 0.6 cm, with clips on the true margin. The true marain is inked black. The specimen is serially sectioned and entirely submitted in F1, F2. (G) NEW LATERAL SUPERFICIAL MARGIN - A portion of tibroadipose tissue, 5.0 x 2.0 x 0.6 cm, with clips on the true margin. The true marain is inked black. The specimen is serially sectioned and entirely submitted in G1-G4. CLINICAL HISTORY Right breast cancer. SNOMED CODEs T-04050, M-85003, T-C4710, M-85006 "Some tests reported here may have been developed and performance characteristics These tests have not been. determined by specifically cleared or approved by the U.S. Food and Drug Administration." Released by: ..-END OF REPORT-..
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diff --git a/output/text/721a1662-f3fb-49b4-9455-e656270379ce.txt b/output/text/721a1662-f3fb-49b4-9455-e656270379ce.txt
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index 0000000000000000000000000000000000000000..6f49fcf6df348a8c41214885bc0918b4848ec176
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+--- Page 1 ---
+ics-0 -3 Cascunomr, cuct Nos, mfiltraHir 85oo/3 Site Codi. buast NO5 c50.9 Patient: 1/17/11 h Surgicat Pathotogy:Fmat Surg Path UUID:CFC4801B-04BD-4FFC-911A-7B88E2FA4B49 TCGA-B6-A0IB-01A-PR Redacted CLINICAL HISTORY: Right breast cancer. GROSS EXAMINATION: A. "Right breast":  Received fresh is a 25 x 17 x 3.5 cm right breast and axillary tail. Attached to the breast is an 18 x 9 cm ellipse of skin containing the nipple. In the inner upper and inner lower quadrant there is a 6 x 3.5 x 3.0 cm biopsy cavity. Surrounding the biopsy cavity is firm to hard breast tissue.  This tissue extends from the biopsy cavity from 1.0 x. 2.5 cm in all directions. Tissue from this main tumor mass was submitted for estrogen receptors labeled as "a". Approximately 5 cm lateral to the biopsy. cavity there is another nodule within the breast that measures approximately 3 cm in diameter. Tissue from this smaller mass was submitted for estrogen receptors labeled as "b". Small amounts of firm breast tissue are palpated between the main tumor mass in this second 3 cm tumor mass. It is difficult. to determine whether this second tumor mass is an isolated lesion or an extension of the main tumor mass.. Block Summary: Al: Section adjacent to biopsy cavity containing a deep margin which has been. inked blue. A2: Section adjacent to biopsy site containing deep margin. A3: Random section of tumor adjacent to biopsy site.. A4: Section of firm area between the biopsy cavity and the smaller mass lateral to it. A5: Section of the 3 cm in diameter mass lateral to the biopsy cavity. A6: Upper outer quadrant. A7: Lower inner quadrant. A8: Skin beneath the biopsy cavity. A9: Nipple. A10: Lymph nodes from the proximal 1/3 of the axillary tail. All: Lymph nodes from the mid 1/3 of the axillary tail.. Al2: Lymph nodes from the distal 1/3 of the axillary tail. DIAGNOSIS: A. "RIGHT BREAST": RIGHT BREAST STATUS POST BIOPSY FOR INVASIVE DUCTAL CARCINOMA WITH EXTENSIVE RESIDUAL INVASIVE CARCINOMA EXTENDING INTO THE DEEP DERMIS (BLOCK A8). HISTOLOGIC GRADE: III. NUCLEAR GRADE: III. B. "LYMPH NODES": LEVEL-I, NEGATIVE FOR CANCER, ONE EXAMINED. LEVEL-II, LYMPH NODES POSITIVE FOR CANCER, SIX OF NINE EXAMINED. LEVEL-III LYMPH NODES POSITIVE FOR CANCER, TWO OF FIVE EXAMINED. ALL FINAL SURGICAL MARGINS NEGATIVE FOR CANCER.S Verified by: (Eiectronic Signature; Date Sign eBrowser Resulf 1 of 1
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diff --git a/output/text/722b330f-dc37-4ff8-9de8-b549805e6c6b.txt b/output/text/722b330f-dc37-4ff8-9de8-b549805e6c6b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..bd9852982a7abd2a3c587fb5f7d3496a734f79ea
--- /dev/null
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+HISTORY : with biopsy confirmed squamous cell carcinoma in the left retromolar trigone. Cperative Procedure: Left resection left retromolar rigone. GROSS: 'Posterior lateral tongue." Received fresh for frozen section analysis is a. 1.2 cm fragnent of mucosa. All tissues frozen. IA. Frozen section control. "Anterior lateral tongue.' Received fresh for frozen section analysis are three tissue fragments, largest 1.3 cm. All tissues submitted for frozen section. 2A. Frozen section control. 'Mucosa adjacent to first molar.' Received fresh for frozen section analysis are two 0.3 cm mucosal fragments. All tissues submitted for frozen section. 3A. Frozen section control. "Anterior floor of mouth. Received fresh for frozen section analysis are two 0.6 cm mucosal fragments All tissues submitted for frozen section. 4A. Frozen section control. "Tongue base.' Received fresh for frozen section analysis is a 1 cm fragment of mucosa. All tissu. Submitted for frozen section. 5A. Frozen section control. 'Retromolar trigone.'  Received fresh for frozen section analysis is a 0.3 cn fragment of mucosa. All tissues submitted for frozen section analysis. SA, Frosen segtion -control. 'Buccal mucosa." Received fresh for frozen section analysis is a 1.5 cm Eragrent of mucosa. All tissues submitted for frozen section. 7A. Frozen section control. 8. "Deep margin.' Received fresh for frozen section analysis are two 0.2 cm tissue fragments. All tissues  submitted for frozen section. 8A. Frozen section control 'Soft palate. Received frozen section analysis are 2 fragments measuring 1.2 and 0.7 cm. All tissues submitted for frozen section. 9A. Frozen section control. 10. 'Left retromolar trigone with tonsil.' Received unoriented in a small container of formalin are two portions of tissue. The larger measures 3.3 x 3 x 1.7 cm. The smaller measures 1.4 x 0.5 x 0.4 cm. The larger portion consists of soft tissue including mucosa and tonsillar tissue. Within the tissue is an ulcerated lesion measuring 2.2 x 1.5 x 1 cm. The lesion reaches the anterior soft tissue and mucosal edge and fccally reaches the superior mucosal soft tissue edge. The lesion is within 2 mn of the inferior soft tissue edge and posterior soft tissue edge. Lesion is also within 2 mm of the deep {lateral! soft tissue edge. The tumor is semi firm and white and well-demarcated. The soft tissue edges are inked green. Representative sections are submitted. Photographs are taken. 10A. Sample of superior edge. 103-c. Sample of tumor showing anterior deep and posterior edges. (1ss each) 10D. Sample of inferior edge. "Left neck section Level I.' Received in formalin in a small container is a 7.2 x 5.6 x 2.8 cm portion of yellow fibroadipose tissue. A 4.2 x 2.2 cm submandibular gland is identified. Multiple polyps and lymph nodes are identified, ranging up to i.5 cm. 11A. Sucmandicular gland.
+
+--- Page 2 ---
+113. Muitiple possible lymph nodes. 11c-F. One bisected lyrph node each 12. 'Left neck section Level II.- Received in formalin in a small container is a 9.2 x 5.3 x 3.2 cm irregular portion of pink-yellow fibroadipose tissue. Multiple possible lymph nodes are identified ranging up to 2.2 cm in greatest dimension. Cut surface of the largest lymph node is gray-white, and granular. 12A. Multiple possible lyrph nodes. 12B. One bisected lymph node. 12C. One trisected lymph node 12D. One bisected lymph node. 12E. Largest lymph node. 13. 'Left neck dissection Level Iii.- Received in formalin in a small container is a 4.5 x 3.6 x 1.8 cm irregular portion of pink-yellow. fibroadipose tissue. Multiple possible lymph nodes are identified ranging up to 1.l cm. 13A. Multiple possible lyuph nodes. 14. 'Left neck dissection Level Iv.. Received in formalin in a srrall container is a 4.2 x 2.8 x 1.3 cm aggregate of yellow fibroadipose tissue. Multiple possible lymph nodes are identified, ranging up to 0.6 cm. 14A. Multiple possible lymph nodes. Fat retained. FROZEN SECTION REPORT 1-9) Negative for neoplasm have reviewed and interpretei the frozen section. material at the time it reguested. Permanent sections confirm frozen section report.. MICROSCOPIC DIAGNOSIS: -9. Intraoperative margins, please see above for sites, excision: Negative for carcinoma. 10. Left retromolar trigone and tonsil, resection: Invasive moderately differentiated squamcus cell carcinoma (2.2 cm). Please see template. 11. Lynph nodes, left neck level I, dissection: Seven lymph nodes negative for malignancy. Unremarkable salivary glard.. 12. Lymph nodes, left neck level II, dissection: Metastatic sguamous cell carcinoma involving one of seven lymph nodes (1/7). No extranodal extension. 13. Lymph nodes, left neck level Ir, dissection: Seven lymph nodes negative for malignancy. 14. Lymph nodes, left neck level Iv, dissection: Nine lymph nodes negative for malignancy. the signing staff pathologist, have
+
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+EClbse
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diff --git a/output/text/7245cede-7ed9-47c5-8571-8c99197feb08.txt b/output/text/7245cede-7ed9-47c5-8571-8c99197feb08.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c8233e828b157e907cc3812a52cb8dcf0105c6e7
--- /dev/null
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+
+--- Page 1 ---
+UUID:4D9A2D24-529F-4CFE-8444-013FAAF696EC TCGA-NH-A8F7-01A-PR Redacted RUN DATE: PAGE 1 RUN TIME: Lab Database: RUN USER: ACCT #: LOC: PATIENT: AGE/SX : /F ROOM : REG DR: DOB: BED: STATUS: SPEC #: RECD: STATUS : PERFORMED AT TIME IN FORMALIN: hrs. COLL : COLD ISCHEMA TIME: mins . CLINICAL INFORMATION: Pre-Op Diagnosis: Remarks: Specimen(s) : A. Subtotal colectomy with left tube and ovary. B. Right tube and ovary Sali : Diqmid eslers Ci8.7 MICROSCOPIC DIAGNOSIS C 4/x/14 A COLON. TERMINAL ILEUM, APPENDIX AND OMENTUM (SUBTOTAL COLECTOMY) : TUMOR #1 MODERATELY DIFFERENTIATED ADENOCARCINOMA OF CECUMS TUMOR INVADES THROUGH THE BOWEL WALL METASTATIC CARCINOMA IN 8 OF 23 REGIONAL LYMPH NODES METASTATIC CARCINOMA TO OMENTUM MARGINS APPEAR UNINVOLVED WITH CLOSEST MARGIN RADIAL. <1 CM TO METASTATIC CARCINOMA TUMOR #2 MODERATELY DIFFERENTIATED ADENOCARCINOMA. SIGMOID COLON TUMOR INVADES FOCALLY THROUGH THE BOWEL WALLS relkckl NO METASTASIS IN 18 REGIONAL LYMPH NODES MARGINS APPEAR UNINVOLVED WITH CLOSEST MARGIN DISTAL AT 5 CM FROM TUMOR Secer LEFT FALLOPIAN TUBE AND OVARY (SALPINGO-OPHORECTOMY).; ted mhfris METASTATIC ADENOCARCINOMA TO OVARY fomovar RIGHT FALLOPIAN TUBE AND OVARY (SALPINGO-OOPHORECTOMY) :  METASTATIC ADENOCARCINOMA TO FIMBRIATED END OF FALLOPIAN TUBE COMMENT(S) The subtotal colectomy contained two separate but histologically indistinguishable. moderately differentiated adenocarcinomas. Tumor #l was located in the cecum and appeared more advanced with numerous metastasis to regional lymph nodes. Tumor #2 was located in the sigmoid colon without regional lymph node metastasis. In completing the synoptic reports below. I judged the metastatic tumor to be associated with the more advanced cecal adenocarcinoma. ** CONTINUED ON NEXT PAGE **
+
+--- Page 2 ---
+PAGE 2 RUN DATE: Specimen Inquiry RUN TIME: Lab Database: RUN USER: SPEC # PATIENT: (Continued) #- COmment(s) (Continued) SURGICAL PATHOLOGY CANCER CASE SUMMARY (CECAL TUMOR) - CAP APPROVED Torminal ileum. cecum. appendix. ascending colon. Specimen: transverse colon. descending colon. sigmoid colon. bilateral ovaries and fallopian tubes. omentum. Subtotal colectomy with BSO Procedures: CECAL TUMOR: Tumor Site: Cecum Tumor Size: 4.5 cm in greatest dimensions. Not identified Macroscopic Tumor Perforation:. Histologic Type: Adenocarcinoma Histologic Grade: Low-grade Microscopic Tumor Extension: Tumor invades through the muscularis propria into the subserosal adipose tissue or the nonperitonealized pericolic or perirectal soft tissues but does not extend to the serosal surface Proximal. distal and radial margins appear uninvolved Margins: with metastatic tumor within 1 cm of radial margin at ileocecal junction Treatment Effect: No prior treatment Lymph-Vascular Invasion Present Not identified Perineural Invasion: Tumor Deposits: Present Primary Tumor: pT3 Pathologic Staging: Regional Lymph Nodes: pN2b Number examined: 23 Number involved: 8 Distant Metastasis: pMib - metastasis to left. ovary. right fallopian tube and omentum. SIGMOID TUMOR Sigmoid colon Tumor Site: 5.5 cm in greatest dimensions. Tumor Size: Macroscopic Tumor Perforation: Not identified Histologic Type: Adenocarcinoma Histologic Grade: Low-grade Tumor invades through the muscularis propria into the Microscopic Tumor Extension: subserosal adipose tissue or the nonperitonealized pericolic or perirectal soft tissues but doss not extend to the serosal surface Proximal. distal and radial margins appear uninvolved Margins: with metastatic tumor within 5 cm from distal margin No prior treatment Treatment Effect Not identified Lymph-Vascular Invasion: Not identified Perineural Invasion: Tumor Deposits: Not identified Pathologic Staging: Primary Tumor: pT3 ** CONTINUED ON NEXT PAGE **
+
+--- Page 3 ---
+RUN DATE: PAGE 3 RUN TIME: Specimen Inquiry RUN USER: Lab Database: SPEC #:- PATIENT: (Continued) comment(s) (Continued) Regional Lymph Nodes: pN0 Number examined: 18 Number involved: 0 Distant Metastasis: not applicable GROSS DESCRIPTION: Specimen A is received in the fresh state labeled "subtotal colectomy with left tube and Ovary". The specimen consists of the following: 15 cm of terminal ileum measuring 2 cm in diameter. Vermiform appendix measuring 5 cm in length by 0.7 cm in diameter. 65 cm of large intestine measuring approximately 5 cm in diameter. Attached omentum measuring 20 x 14 by up to 2 cm in thickness An ovary and fallopian tube attached in the area of the sigmoid colon. Mesentery measuring up to 9 cm in radial dimension at the ileocecal junction and up to 9 cm in radial dimension at the sigmoid colon. Adhesions are noted at the ileocecal junction and between the ovary and sigmoid colon. There are firm tumorous nodules in the mesentery at the ileocecal junction and in the oment um.  The omental tumor nodule measures 2 cm in greatest dimsnsion. There are multiple mesenteric nodules at the ileocecal junction measuring up to 1.5 cm in greatest dimension. The bowel is opened to reveal a circumferential fungating tumor in the cecum approximately 2 cm from the ileocecal valve. This tumor measures 4 5 cm along the length of the bowel The bowel is narrowed in this area. A second circumferential fungating mucosal tumor is identified 5 cm above the distal margin. This second tumor measures 5.5 cm along the length of the bowel and again the bowel appears narrowed in this area. The attached ovary appears enlarged. measuring 5 x 4.5 x 3 cm. It has a smooth tan surface. Its cut surface. reveals soft tan tumorous tissue replacing 9o% of the ovary. The fallopian tube with fimbriated end measures 4.5 cm in length by 0.5 cm in diameter.. The initial gross features are reported to Dr in the O.R. at The specimen is allowed to fix overnight prior to sectioning. Representativs sections are submitted as follows: A1 terminal ileum A2 vermiform appendix A3-6 - cecal tumor A7-12- lymph nodes in mesentery regional to cecal tumor. A13 apex of ileocecal mesentery A14 omental tumor nodule A15.16-- left ovary and tube A17-20- distal tumor A21 distal margin A22-25- lymph nodes and mesentery regional to distal tumor. NOTE:  The tumors invade the full thickness of the bowel wall, likely extending through the bowel wall. Specimen B is received in formalin labeled "right tube and ovary". This is an ovary with ** CONTINUED ON NEXT PAGE **
+
+--- Page 4 ---
+RUN DATE: PAGE 4 RUN TIME: Specimen Inquiry RUN USER: Lab Database: SPEC #: PATIENT : (Continued) GROSS DESCRIPTION:(Continued) attached fallopian tube. The tube with fimbriated ond measures 4.5 cm in length by 0.5 cm in diameter. The ovary measures 3.5 x 1.2 x 1 cm. It has a normal appearing wrinkled tan obvious tumor.  Representative sections are submitted in cassettes B1 and B2.. INTRAOPERATIVE CONSULTATION: SUBTOTAL COLECTOMY. GROSS EXAM:S  TWO SEPARATE COLON CANCERS IDENTIFIED, ONE IN THE CECUM AND THE OTHER 5 CM ABOVE THE DISTAL MARGIN MARGINS APPEAR UNINVOLVEDS FINDINGS REPORTED TO DR. IN THE O.R. AT TUMOR HARVESTED FOR TISSUE BANKING PHOTO ICUMENTATION Image Signed .(signature on file) ** END OF REPORT 
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diff --git a/output/text/725e2a86-17f8-4e51-9148-d6077c6c336d.txt b/output/text/725e2a86-17f8-4e51-9148-d6077c6c336d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c203d4b866eeafd4ddcfbd4825b4ae056ad9a785
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+UUID:6CF9AD5C-60BE-418D-AA95-F128661361D8 TCGA-SC-A6LM-01A-PR  Redacted SURGICAL PATHOLOCY REPORT Patient: Accassion #: MRN' Servicer Account #: Date of Proceaure: DOb: (Age: Date of Receipt: Physician: Date of Report: CC Clinical Diagnosis & History: History of aabestos with left pleural thickening here for Iive biopsy Specimens Submitted: CDO- 1 sp: Left pleural biopay#1(fs) 2: SP; Left pleural biopay (ts) Meesthelixemo 3: sp: Left pleural biopsy fiuse, apitheliosel 952/3 malignar DIAGNOSIS: Jpath 1-3. PLRURA, LEFT, BIOPSY #1, 2, 3: Messthelioma, dyffere -MALIGNANT MESOTHELIOMA, EPITHELIOID TYPE. -IMMUNOHISTOCHENISTRY SHOWS THAT THE TUMOR CELLS ARE POSITIVE FOR WT1 (WEAK), CALRETININ (WEAK), D2-40 (WEAK). AE1:AE3, AND NEGATIVR FOR TTF-1, NAPSIN, AND BER-EP4, SUPPORTING THE DIAGNOSIS. Site D Peww nss c38.4 Some of the immunohistochemistry and Ish tests were developed and their performance characteristics were determined by the Gw 7l5/3 They have not been cleared or approved by the us Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. These tests are uaed for clinical purposes. They should not be regarded as investigational or for research. This laboratory is certified I ATTEST THAT THB ABOVE DIAGNOSIS IS BASED OPON MY PERSONAL EXAMINATION OP THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE RRVIEWED AND APPROVED THIS REPORT. Report electronically Signed Out *** Gross Description: 1). The specir is received fresh for frozen section consultation, labeled ** Continued on next page **
+
+--- Page 2 ---
+-- page 2 or 3 "Left pleural biopsy" and consiats of an aggregate of white-tan mombranous soft tisaue 3.2 x'3.0 x 0.3 cm. Entirely submitted for frozen aection. Summary of sections! FsC --frozen sactton control 3). The specimen is received fresh labeled "Left plaural biopsy." It consists of multiple pieces of brown-tan membranoua soft tissue measuring 0.5 x 3 x 0.6 cm in aggregate. The specimen is sectioned and submitted entiroly Suamary of sections: U-undesignated Summary of Sections:. Part 1: SP: Left pleural biopsy#1(fs) Block Sect. site PCs H  {not entered} fac Part 2: Sp: Left pleural biopsy (fs) ... Site. PCa. Block. Sect. rsc Part 3 SP: Left pleural biopsy. Block Sect. Site PCa u Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the tissue aample examined at the time of the intraoperative consultation. FROZEN SECTION DIAGNOSIS: SP: LEFT PLEURAL BIOPSY #1(FS) : 1. SUSPICIOUS FOR MESOTHELIOMA PERMANENT DIAGNOSIS: SAME 2. FROZEN SECTION DIAGNOSIS: SP: LEFT PLEURAL BIOPSY #2 (FS) : SUSPICIOUS FOR MESOTHELIOMA PERMANENT DIAGNOSIS:S SAME Continued on next j
+
+--- Page 3 ---
+Note: The diagnoses given in this section pertain only to the tissue sample examinedat-the"timeof~the-intraoperative FROZEN SECTION DIAGNOSIS: SP: LEFT PLEURAL BIOPSY #1(FS) : SUSPICIOUS FOR MESOTHELIOMA PERMANENT DIAGNOSIS: SAME 2. FROZEN SECTION DIACNOSIS: SP: LEFT PLEURAL BIOPSY #2 (FS) : SUSPICIOUS FOR MESOTHELIOMAS PERMANENT DIAGNOSIS: SAME End of Report /27//3re
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diff --git a/output/text/72774480-d3ee-452f-962b-90361d2e2271.txt b/output/text/72774480-d3ee-452f-962b-90361d2e2271.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b6c9b59cfcf3d1f425fe2f6ddba9abf70a1999ad
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+--- Page 1 ---
+JCb-0-3 Cavcinoma, mfi1fnstng ductl, Nv,s85oo/3 Sih. Buot Nus c5u.9 1/21  Diagnosis: 2. Left ablated breast material with a 3.5 cm well differentiated invasive ductal breast. carcinoma with focal invasion of lymph vessels, infiltration of the skin and inclusion of an intraductal non-high-grade carcinoma of equal size with comedo necrosis and a minimum basal margin of 0.8 cm and, at 6 o'clock, of 0.6 cm. In the outlying area of the tumor is a proliferating mastopathy with cylindrical epithelial metaplasia and areas of scleradenosis. Tumor classification: M-8500/3, G1, pT4b, pL1, pN1a (2/21), pMX, stage IIIB. R0. UUID: 5D439E4F-F1B7-41F7-BF1D-1F6E93D6427D TCGA-A8-A09B-01A-PR Redacted
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diff --git a/output/text/72795d07-590d-4b1e-9f32-4f83c99c3b59.txt b/output/text/72795d07-590d-4b1e-9f32-4f83c99c3b59.txt
new file mode 100644
index 0000000000000000000000000000000000000000..02241f1e7ca2b48508bb47197bcbbcda91b88eee
--- /dev/null
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+
+--- Page 1 ---
+UUID:14022E87-15A4-415D-A62E-2A99DFB54687 TCGA-B9-A69E-01A-PR Redacted SURGICAL PATHOLOGY Case Number : Diagnosis: A: Kidney, left, total nephrectomy Histologic tumor type/subtype: papillary renal cell carcinoma,. type 2 Sarcomatoid features: not identified. Histologic grade (if applicable): Fuhrman nuclear grade 2 (of 4) Tumor size: 8.0 x 7.2 x 7.0 cm (gross measurement) Tumor focality: unifocal Extent of tumor invasion: Capsular invasion/perirenal adipose tissue: microscopic tumor invasion into but not through capsule. Gerota' s fascia: negative. Renal sinus: negative Major veins (renal vein or segmental branches, Ivc): positive, microscopic Ureter: negative Venous (large vessel): positive, microscopic Lymphatic (small vessel): negative. Histologic assessment of surgical margins: Gerota' s fascia: negative. Renal vein: negative Ureter: negative zcDo-3 Adrenal gland: not submitted Lymph nodes: none submitted. Pathologic findings in non-neoplastic kidney: mild 9J s/14/13 arteriolonephrosclerosis AJcc Pathologic Staging: pT3a pNx This staging information is based on information available at the time of this report, and is subject to change pending eQl g clinical review and additional information. 8260|3
+
+--- Page 2 ---
+Clinical History: -year-old male with left renal mass. Gross Description: Received is one appropriately labeled container, additionally labeled "left kidney." It holds a 1,220 gram, 25 x 12.0 x 10.0 cm nephrectomy specimen. The perinephric fat is inked blue. Within the fat there is a 16.2 x 8.0 x 8.0 cm kidney. Within the lower pole there is an 8.0 x 7.2 x 7.0 cm tan/yellow/red firm, well circumscribed, variegated mass. The mass bulges the capsule, but does not grossly appear to invade through it. The majority of the mass is solid (90%) with the remaining 10% being cystic. The cysts are filled with dark brown liquid. There are no white myxoid areas grossly noted. The mass does not invade into the sinus fat or involve the pelvis. The remainder of the kidney parenchyma is red/brown with a distinct corticomedullary junction. The renal vein artery and ureter are all patent. The adrenal gland is not grossly identified.. Block summary: Al - ureter, vein and artery margins, en face A2-A3 - mass with respect to capsule. A4-A6 - additional sections of mass. A7 - uninvolved kidney away from mass. A8 - additional section of normal kidney away from mass Tumor and normal are submitted to. 5/ AD3
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diff --git a/output/text/72cb30ff-efba-49aa-b886-6bf25ce6731e.txt b/output/text/72cb30ff-efba-49aa-b886-6bf25ce6731e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4781a3b84e441260c4b815809244107c0f65e309
--- /dev/null
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+--- Page 1 ---
+page 1 / 2 Department of Cancer Pathology copy No. Date: Examination: Histopathological examination. Internal invoice No. Cost of diagnostic procedure Examination No.: Patient: xxx PESEL: XXX Age: Gender: F 1cs-0-3 Material: Multiple organ resection - right breast. ! Unit in charge: Cocnonr, nfilfnaHq duct,Nos 85os/3  Physician in charge: Si+x:brot, Nos C50.9 w4]f1 Material collected on. Material received on: '. Expected time of examination: up to 8 working days Clinical diagnosis: Bifocal cancer of the right breast. Examination performed on: Results of immunohistochemical examination: Tumour 1. No estrogen receptors found in neoplastic cell nuclei. No progesterone receptors found in neoplastic cell nuclei. HER2 protein stained using rabbit antibody Ventana PATHway HER-2/neu (485). Positive reaction in invasive cancerous cells (Score = 3+) Tumour 2 No estrogen receptors found in neoplastic cell nuclei. No progesterone receptors found in neoplastic cell nuc!ei. HER2 protein stained using rabbit antibody Ventana PATHwAy HER-2/neu (4B5). Positive reaction in invasive cancerous cells (Score = 3+) validated by:  Examination performed on: : Macroscopic description: Right breast siz@d 26 x 19 x 5 cm with axillary tissues sized 11 x 8 x 2 and a skin flap of 24 x 2.5 cm.. Tumour sized 1.6 x 1.5 x I.3 cm found on the boundary of lower quadrants, located 1.3 cm from the lower boundary, 1 cm from the base and 4 cm from the skin. The other tumour present in the upper outer quadrant, sized 1.6 x 1.5 x 1.2 cm, removed by 0.1 cm from the base, 0.6 cm from the skin and 3 cm from the upper boundary.. Microscopic description: Both tumours: Carcinoma ductale invasivum NHG3 (3+3+2/ 12 mitoses /10 HPF, visual area diameter: 0.55mm). Few foci of carcinoma ductale in situ (Dcis) (papillary type, with medium nuclear atypia and comedo necrosis of 5% of. the tumour).. In situ lesions of the type carcinoma intraductale mamillae.. Glandular tissue showing parenchymal atrophy. AXILLARY LYMPH NODES:Metastases carcinomatosae in lymphonodis (No III/x). UUID:99050E48-8DFE-4405-88D8-7649CE2C9CFF TCGA-D8-A1XT-01A-PR Redacted
+
+--- Page 2 ---
+page 2 / 2 Examination: Histopathological examination Examination No.: Patient: xxx PESEL: XXX Gender: F Examination performed on:. Infiltratio telae perinodalis. Test result: Carcinoma ductale invasivum bifocale et ductale in situ mammae dextrae. Invasive bifocal ductal carcinoma and ductal. carcinoma in situ of the right breast: Metastases carcinomatosae in lymphonodis axillae (No Ill/x). Cancer metastases in axillary Jymph nodes (NHG3, pTIc, pNIa). Compliance valida.. CONTACT YOUR DOCTOR WITH THIS REPORT!
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diff --git a/output/text/72d91ab2-4250-45e7-bf5d-c488628940c4.txt b/output/text/72d91ab2-4250-45e7-bf5d-c488628940c4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f72b2ee47d370eda769cd93f79a5c423f392da9a
--- /dev/null
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+
+--- Page 1 ---
+Tumor entity This concerns a moderately differentiated, invasive colic adenocarcinoma, partly of the type of an extracellular mucus-forming carcinoma with penetration of all wall layers (pT3 L0, V0), with free resection margins and concomitant chronic recurrent appendicitis. There are also free lymph nodes. pNO
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diff --git a/output/text/736ecfa9-5105-4e08-aff7-202f71bf869a.txt b/output/text/736ecfa9-5105-4e08-aff7-202f71bf869a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1da7b5bd4f0192fa04f908d64d79ffa84e96ce50
--- /dev/null
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+
+--- Page 1 ---
+JC.s-0-3 Carcincmh, hfiltrating 1obulu, Nos 8520/3 Sit: Bruist Nos C50.9 19/ Diagnosis: Invasive lobular breast carcinoma (maximum diameter 2.5 cm, malignancy grade II), with excision extending into the healthy tissue Tumor classification (also taking into account xxxxxxxx): pT2 (maximum diameter 2.5 cm), pN0 sn (0/1), MX, R0, G2 (L0, V0). UUID: 38C6CE69-2641-4B6D-85DF-E8FE838015D0 TCgA-A8-A0A1-01A-pR Redacted
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diff --git a/output/text/738cc446-d211-4806-95d9-9c9734949b4a.txt b/output/text/738cc446-d211-4806-95d9-9c9734949b4a.txt
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+UUID:F5B17108-8904-48E7-9B3D-182F0EA38887 TCGA-AR-A251-01A-PR Redacted Final Diagnosis Was/ east, left/ wide local excision: Infiltrating ductal carcinoma, Nottingham grade III (of III), forming a 2.7 x 2.4 x 2.0 cm bilobed mass [AJCC pT2]. Extensive ductal carcinoma in situ, high nuclear grade, present within (>25%) and outside the invasive component. Angiolymphatic invasion is present. The non-neoplastic breast parenchyma shows proliferative fibrocystic changes.. Calcifications present in malignant ducts. Biopsy site changes present. The tumor does not involve overlying skin. The medial/inferior margin is positive for ductal carcinoma in-situ. Left breast, new inferomedial margin, re-excision: Focally positive for ductal carcinoma in- situ. Left breast, new deep margin, re-excision: Negative for tumor. Lymph nodes, left axillary, dissection: Multiple (3 of 7) left axillary lymph nodes are positive for metastatic carcinoma. The. largest metastatic focus measures 2.2 x 1.9 x 1.5 cm. Extranodal extension is present. Lymph nodes, additional left axillary, excision: A single (of 3) left axillary lymph node is positive for metastatic carcinoma.. [Total 4 positive lymph nodes; AJCCpN2]. Breast, left, total mastectomy: No residual carcinoma identified. Biopsy site changes are present in the outer quadrant. The adjacent breast parenchyma shows proliferative fibrocystic changes. Surgical margins are negative for tumor. The nipple is. without diagnostic abnormality. Ics-0-3 Carcin 0nu mfi1tnatxg cuct Nos 85oo/3 Sits: brenst, N0s c50.9 hs 4/35/11
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diff --git a/output/text/7397e509-b9af-4e03-a0cc-c40fbfdcb71d.txt b/output/text/7397e509-b9af-4e03-a0cc-c40fbfdcb71d.txt
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+TSS ID SPECIMENS: ic-0- 3 A. WLE LEFT BREAST NEEDLE LOCALIZATION B. SENTINEL LYMPH NODE #1 LEFT AXILLA C. SENTINEL LYMPH NODE #2 LEFT AXILLA Par Sitl: brast, uppw ontw gusdrent. C5u.4 D. SENTINEL LYMPH NODE #3 LEFT AXILLA E. SENTINEL LYMPH NODE #4 LEFT AXILLA CqcF sif: srst,noy c5O.9 2/8/n F. SENTINEL LYMPH NODE #5 LEFT AXILLA h SPECIMEN(S): A. WLE LEFT BREAST NEEDLE LOCALIZATION B. SENTINEL LYMPH NODE #1 LEFT AXILLA C. SENTINEL LYMPH NODE #2 LEFT AXILLA UUID:E0CCE6AD-38A6-446C-ACF7-358C1DFC59F8 TCGA-e2-A1IL-01a-Pr Redacted D. SENTINEL LYMPH NODE #3 LEFT AXILLA E. SENTINEL LYMPH NODE #4 LEFT AXILLA F. SENTINEL LYMPH NODE #5 LEFT AXILLA INTRAOPERATIVE CONSULTATION DIAGNOSIS:  Part A, WLE Left breast, needle localization, gross examination: Tumor is 1 cm from posterior/inferior. margin TPB, Sentinel node #1, biopsy: No tumor seen TPC, Sentinel node #2, biopsy: No lymphoid tissue grossly identified, no lymphocytes or tumor seen TPD, Sentinel node #3, biopsy: No tumor seen TPE, Sentinel node #4, biopsy: No tumor seen TPF, Sentinel node #5, biopsy: No tumor seen Diagnoses called at (Part A) and .(Parts B-F) by Dr. GROSS DESCRIPTION: A. WLE LEFT BREAST NEEDLE LOCALiZATION Received fresh labeled with the patient's identification and designated "wide local excision left breast needle localization" is an oriented, previously inked, 39-g, 25 x 5.2 x 2.7 cm needle localized Jumpectomy specimen accompanied by two radiographs. The single suture designates anterior, double-lateral. Ink code: Anterior-yellow, posterior-black, medial-green, lateral-red, superior-blue, inferior-orange. The specimen is serialy sectioned from medial to lateral into 6 slices revealing a firm tan mass with surgical clip (slice 3), 1.5 x 1 x 0.9 cm, located 1 cm from the nearest posterior/inferior margin. A portion of the specimen is submitted for tissue procurement. The specimen is representatively submitted: A1-A5: Medial margin, perpendicular sections, entirely submitted. A6: Mass, slice 2 with posterior and anterior margins A7-A11: Slice 3 entirely submitted, A7-A8 demonstrating tumor (clip) and nearest posterior/inferior margins A12-A15: Slice 4 entirely submitted, A12 demonstrating mass. A16-A17: Slice 5, posterior/inferior, inferior/anterior, respectively. A18: Representative sections lateral margin B. SENTINEL LYMPH NODE #1 LEFT AXILLA Received fresh labeled with the patient's identification and designated "Sentinel lymph node number one left axilla" is a beige tan lymph node measuring 2 x 1.5 x 1 cm. Touch preparation is performed. Entirely submitted, B1. C. SENTINEL LYMPH NODE #2 LEFT AXILLA Received fresh labeled with the patient's identification and designated "Sentinel lymph node number two left axilla" is a fragment of fibroadipose tissue measuring 2 x 2 x 0.8 cm. Touch preparation is performed. Entirely submitted, C1.. D. SENTINEL LYMPH NODE #3 LEFT AXILLA Received fresh labeled with the patient's identification and designated *sentinel lymph node number 3 teft axilla" is a portion of adipose tissue measuring 4 x 3 x 1 cm, demonstrating one lymph node measuring 0.7-cm in greatest dimension. Touch preparation is performed. The entire lymph node is submitted, D1. E. SENTINEL LYMPH NODE #4 LEFT AXILLA Received fresh labeled with the patient's identification and designated *Sentinel lymph node number 4. left axilla" is a fragment of lymphoid tissue measuring 2 x 1 x 1 cm. Touch preparation is performed. Entirely submitted, E1. F. SENTINEL LYMPH NODE #5 LEFT AXILLA
+
+--- Page 2 ---
+TSS iD Received fresh labeled with the patient's identification and designated "Sentinel lymph node number 5 left axilla" is a tan lymph node measuring 1.2 x 1 x 0.6 cm. Touch preparation is performed. Entirely. submitted, F1. DIAGNOSIS: A. Breast, Left, excisiOn:  NUCLEAR GRADE 2. - iNVASIVE LOBULAR CARCINOMA, MEASURING 1.5-CM, SBR GRADE I1, - DUCTAL CARCINOMA- IN -SITU, NUCLEAR GRADE 1-2/3. - RADIAL SCAR - PREVIOUS BIOPSY SITE CHANGES.E - SURGICAL RESECTION MARGINS ARE NEGATIVE FOR TUMOR. SEE SYNOPTIC REPORT. B. SENTINEl LYmPH NODE #1, LEft AXILLA, EXCISION: - ONE REACTIVE LYMPH NODE. - NEGATIVE FOR METASTATIC CARCINOMA (O/1). C. SENTINEL LYMPH NODE #2, LEFT AXILLA, EXCISION: - BREAST TISSUE WITH STROMAL FIBROSIS. - NO MALIGNANCY IS SEEN. D. SENTiNEL LYmPH NODE #3, LEFT AXILLA, EXCISION: - ONE LYMPH NODE, POSITIVE FOR METASTATIC LOBULAR CARCINOMA (1/1). E. SENTINEL LYMPH NODE #4, LEFT AXiLLA, EXCISION: - ONE REACTiVE LYMPH NODE. - NO METASTATIC CARCINOMA IS SEEN (0/1). F. SENTINEL LYMPH NODE #5, LEFT AXILLA, EXCISION: - ONE REACTIVE LYMPH NODE. - NO METASTATIC CARCINOMA IS SEEN (0/1). SYNOPTIC REPORT - BREAST Specimens involved SpecimenS: A: WLE LEFT BREAST NEEDLE LOCALIZATION Specimen Type: Excision Needle Localization: Yes - For mass Laterality: Left Invasive Tumor: Present Multifocality: No WHO CLASSIFICATION Invasive lobular carcinoma 8520/3 Tumor size: 1.5cm Additional dimensions:. 1cm x 0.9cm Tumor Site: Upper outer quadrant. Margins: Negative Distance from closest margin:  Greater than 1cm inferior 3 Tubular Score: Nuclear Grade: 2 Mitotic Score: 1 Modified Scarff Bloom Richardson Grade:. 2 Necrosis: Absent Vascular/Lymphatic Invasion:Indeterminate Lymph nodes: Sentinel lymph node only. Lymph node status: Positive 1 / 4 Micrometastases: No DCIS present DCIS Quantity: Estimate 5%
+
+--- Page 3 ---
+TSS ID 1 DCIS Type: Solid DCIS Location: Associated with invasive tumor Nuclear grade: Low Necrosis:  Absent Location of CA++:  Benign epithelium ER/PR/HER2 Results ER: Positive PR: Positive HER2: Negative by IHC Performed on Case: Pathological staging (pTN): pT 1c N 1a Comment(s): Few microcalcifications are seen in the invasive tumor CLINICAL HISTORY: Core biopsy proven cancer upper outer quadrant left breast. PRE-OPERATIVE DIAGNOSIS: Left breast carcinoma Gross Dictation... . Microscopic/Diagnostic Dictation:, M.D.. Pathlogist, Final Review:, M.D., Pathoiogist, Final:, M.D., Pathologist, 1
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diff --git a/output/text/73a2e1fd-2a54-4626-bd94-fb60cbfaf389.txt b/output/text/73a2e1fd-2a54-4626-bd94-fb60cbfaf389.txt
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index 0000000000000000000000000000000000000000..506729b4b3fc3f45ae33e295544d8a85715de1a4
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+UUID:164CD26F-CF77-4490-BF05-BDA5881AC30E TCgA-FD-A3b4-01A-pR Redacted Pathology Report: Surgical Pathology Report FINAL PATHOLOGIC DIAGNOSIS pelvic exenteration and lymph node dissection;. A. Scar tissue-abdomen:. - Skin and subcutaneous tissue with fibrosis, no tumor present.. B. Anterior pelvic exanteration:. - Urothelial carcinoma of the urinary bladder, high grade, with extensive. squamous differentiation,"involving left' intramural ureter and transmurally invasive into anterior cervical wali and vagina.. - Urothelial carcinoma in situ (flat urothelial carcinoma).  Extensive perineural invasion  No unequivocal lymphovascular invasion present.. - Margins of resection (soft tissue, urethra, right and left ureter), no tumor present. - See pathologic parameters and comment. - Uterus with atrophic endometrium and leiomyoma (0.6 cm), no tumor. present. -'Left fallopian tube with paratubal cysts, no tumor present.. - Bilateral ovaries and right fallopian tube with no significant pathology, no tumor present. Left ureter:  Segment of ureter, no tumor present. D. Right distal ureter: Segment of ureter, no tumor present. E. Right hypogastric node: 'Three lymph nodes, no tumor present (0/3).. F. External iliac: - Three 1ymph nodes, no tumor present (0/3). G. Presacral' node: jcs-0-3 - One 1ymph node, no tumor present (0/1). H. Common iliac: cacnoma uruthub'cl njos 812oj3 - One lymph node, no tumor present (0/1). I. Paracava: PnH: Site: b1idd, Wall, Ncs Cl7.9 - One lymph node, no tumor present (0/1). J. Left oburator: CQcF : b1nddw,wnl, 1ntral c4'7.2 - One 1ymph node, no tumor present (0/1). K. Left common iliac: - Four lymph nodes, no tumor present (0/4). 10fa1n L. Left hypogastric: Three' 1ymph nodes, no tumor present (0/3). M. Left common node: Two lymph nodes, no tumor present (0/2). N. Distal right ureter: Segment of ureter, no tumor present.. 0. Right obturator lymph node: -'Eight lymph nodes, no tumor present (0/8). P. Round ligament: - Dense Fibromuscular tissue, no tumor present.. Urothelial Carcinoma Pathologic Parameters Tumor type: Urothelial carcinoma with extensive squamous differentiation. 1. 2 . Grade of tumor: High grade Page 1
+
+--- Page 2 ---
+3. Depth of invasion: Extravesical adipose tissue, anterior cervical wall and. vagina 4. Tumor distribution: Solitary (8.5 x 7 x 3.5 cm) Right lateral wall Left lateral wa11 Anterior wal7 Posterior wa11 5. Ureteral margins: Negative 6. Distal urethral margin: Negative 7. Soft tissue margin or serosa: Negative 8.  Lymph nodes: Twenty seven lymph nodes, no tumor present (0/27) 9. pTNM: pT4a, NO, MX Effective this Checklist utilizes the 7th edition TNm staging system for Bladaer oi cne American Joint Committee on Cancer (Ascc) and the. International Union Against Cancer (uicc). Comment The entire invasive portion of the tumor consists of keratinizing squamous carcinoma. The in-situ component shows both urothelial and squamous'cel1 carcinoma differentiation (slide labeled Bl1). Therefore, the tumor is considered urothelial carcinoma with extensive squamous differentiation. xxx [], m.d Interpretation performed by the Attending Pathologist and reviewed with the Resident/Fellow, [ m.D Electronically Signed Out by [] M.D clinical history: The patient is a -year-old female with a history of bladder cancer who undergoes pelvic exenteration. Specimens Received: A: Scar tissue-abdomen B: Anterior pelvic exanteration c: Left ureter D: Right distal ureter. E: Right hypogastric node F: Externa1 iTiac G: Presacral node H: Common iliac I: Paracava J: Left oburator. K: Left common iliac L: Left hypogastric M: Left common node. N: Distal right ureter. O: Right obturator lymph node p: Round ligament Gross Description: The specimens are received in 16 containers each labeled with the patient's name and medical record number. Part A. is no additional designation. Received fresh and placed in formalin are. 2 elliptical portions of wrinkled brown skin. One is 7.1 x 2.3 cm, excised  to a maximum depth of 0.3 cm, and the second is 6.2 x 2 cm, excised to a maximum. Page 2
+
+--- Page 3 ---
+depth of 0.4 cm. Sectioning reveals no masses or lesions. A representative section of each piece is submitted in Al. Part B. is further labeled "2. Anterior pelvic exenteration". Received fresh and placed in formalin is a specimen consisting of bladder and uterus which is overall 20 x 11 x 5.5 cm.' The bladder is 10 x 11 x 5.5 cm and covered with Tobulated yellow fibroadipose tissue with cautery artifact. The anterior wall and around the urethral margin is inked blue. There is a small amount of apparent labial tissue adjacent to the urethral margin. The labium is 5 x 3 x 0.4 ^cm_and wrinkled gray-brown and unremarkable. The right ureter js 2.cm 1ong and 2.5 cm in diameter.'The left ureter is 0.6 cm long and 0.6 cm in diameter. After shaving the urethral margin, the bladder is opened along the anterior with a Y-shaped incision, revealing a partially ulcerated, partially fungating mass along the posterior and left wa17 extending across the anterior partially into the right lateral wall. The overall dimensions are 8.5 x 7 cm, with a raised portion up to 1.8 cm above the mucosa. The mass comes within 4 cm of the urethral margin. Sectioning through the left ureter reveals that the mass encases the ureter and extends to the blue inked margin. Sectioning through the posterior wall reveals that the tumor extends to the cervix, with a maximum depth of 3.5 cm. The tumor also extends into the right wall'and comes within 0.1 cm of the inked margin. The uninvolved mucosa is edematous. No 1ymph node candidates are identified in the attached adipose tissue. Gross photographs are taken. Posterior to the bladder is a 9 x 6 cm portion of wrinkled pink-tan mucosa and consists of cauterized tissue. The attached uterus is 5 cm from cornu to cornu 4.8 cm from fundus to lower uterine segment and 3.3 cm from anterior to posterior. The serosa covering the uterus is'glistening red and unremarkable. The left fallopian tube has a white clip. The'left fallopian tube is 8 cm long and_up to 1.2 cm in diameter. The left ovary is 2.5 x 1.8 x 0.9 cm. The right fallopian tube has no clip but is focally disrupted. The length of the distal portion is 7 cm with a circumference of 0.7 cm. The right ovary is 2.5 x 1.5 x 0.7 cm. The bilateral ovaries are bisected to reveal unremarkable gray firm tissue. The uterus is opened from anterior to posterior to reveal a 3.4 x 0.3 by 0.3 cm endometrial cavity with unremarkable tan 1ining. No masses or lesions are identified in the uterus. Sectioning through the anterior and posterior endomyometrium reveals an endometria1 thickness of less than O.1 cm. The posterior endomyometrium has a maximum thickness of 1.4 cm, and the anterior endomyometrium has a maximum thickness of 2 cm. There is a'single white whorled nodule in the anterior myometrium which is 0.6 cm in greatest diameter. The endocervical canal is 1.8 cm long with unremarkable tan trabeculated mucosa.. Representative sections are submitted as follows:. B1: urethral margin. B2: Left ureter margin. B3: Right ureter margin B4: Labia D5 closest approach to urethral margin. B5: Approach of tumor to urethral margin. 36 and 37 section through 1eft ureter,'bisected. B8 and b9: Section through ureter and'anterior cervix, bisected. B 10: Anterior wall tumor B. 11: Tumor in the right wall B12: Uninvolved dome of bladder B. 13: Posterior cervix B. 14: Anterior endomyometrium including whorled nodule. B. 15 posterior endomyometrium B. 16: Right ovary and fallopian tube. B-17 1eft ovary and fallopian tube. Part c. is further designated all 3. Left ureter". Received fresh for. Page 3
+
+--- Page 4 ---
+intraoperative diagnosis is a 1 cm long specimen with a staple approximately in the middle. The specimen is bisected and both halves are frozen. The frozen section diagnosis'is low benign ureter (both ends)" per Dr.[] The frozen section remnant and entirely submitted in c1. Part D. is further designated "4. Right distal ureter". Received fresh for intraoperative diagnosis is a 1 cm long portion of ureter with a staple in. approximately the middie. The specimen'is bisected and both halves are frozen. The' frozen section diagnosis is'"benign ureter (both ends)" per Dr. []. The. frozen section remnant'is entirely submitted in D1. Part E. is further designated "5. Right hypogastric node". Received fresh and placed in formalin is a 2.5 x 2 x 1.3 cm aggregate of 1obulated fibrofatty tissue. Sectioning reveals 2 lymph node candidates ranging from 1.5 to 2 cm in greatest dimension.' Each candidate is bisected and the specimen is entirely submitted as follows: E1: one lymph node candidate e2: One lymph node candidate E3: remaining fibrofatty tissue Part F. is further designated "6. External iliac". Received fresh and placed in. formalin is a 5 x 3 x 1.5 cm aggregate of lobulated yellow tan fibrofatty tissue. Sectioning for lymph nodes~reveals one lymph node candidates ranging from 1.5-1.6 cm in greatest dimension. The specimen is entirely submitted as follows: F1: One lymph node candidate. F2: one jymph node candidate, bisected F3: one 1ymph node candidate, bisected F4: one iymph node candidate, bisected F5 F6: remaining fibrofatty tissue Part G. is further designated "7. Pre-sacral node". Received fresh and placed in formalin is a 2.8 x 2 x 1 cm aggregate of lobulated fibroadipose tissue.. Sectioning reveals no obvious Tymph node candidates. Specimen is entirely submitted in g1 and G2 Part H is further designated "8. Common iliac". Received fresh and placed in tissue. Sectioning reveals a single'lymph node candidate measuring 1.5 cm in greatest diameter. The specimen is entirely submitted as follows: H1: Lymph node candidate, bisected H2: remaining fatty tissue Part I is further designated "9.Paracaval". Received fresh and placed in formalin is a 1.5 x 1.2 x 0.6 cm aggregate of lobulated fibrofatty tissue with a 0.5 cm in greatest lymph node candidate. The specimen is entirely submitted in 11. Part J. is further designated "10. Left obturator" Received fresh and placed in formalin is a 3.4 x 2.9~x 1.3 cm aggregate of a relatively firm fibrous tissue with 1obulated yellow adipose tissue. Individual lymph nodes cannot be identified. The' specimen is sectioned and entirely submitted in Jl-J5.. Part k. is further designated "11 left common iliac.". Received fresh and placed in formalin is a 3.5 x 3 x 1.5 cm aggregate of lobulated yellow-tan fibrofatty tissue. Dissection for 1ymph nodes reveals 3 lymph node candidate ranging from 1-2.2 cm in greatest diameter. The specimen is' entirely submitted as follows: K-1: One lymph node tissue, bisected K2: One lymph node candidate, bisected K3 and k4: One lymph node candidate, bisected K5 and k6: Remaining fibrofatty tissue Page 4
+
+--- Page 5 ---
+Part L. is further designated "12. Left hypogastric". Received fresh and placed. in formalin is a 2.6 x i.7 x 1.7 cm aggregate of fibrofatty tissue. Dissection for lymph nodes reveals 2 lymph node candidates ranging from 0.5-1.1 cm in greatest diameter. The specimen is entirely submitted as follows:. L1: 1 iymph node candidate L2: One lymph node candidate, bisected. L3 and L4: Remaining fibrofatty tissue Part m. is further designated "13. Left common node". Received fresh and placed reveals one lymph node candidate, 5 cm in greatest dimension. Specimen is entirely submitted as follows: M1 - m3: One 1ymph node candidate, section. M4 - 6: Remaining fibrofatty tissue Part N is further designated "14. Distal right ureter". Received fresh and. placed in formalin is a 1.7 cm long by 1 cm in diameter portion of apparent ureter. There is a stitch at one end which is not designated. This end is taken to be not to the margin is inked black. The end with the presumed margin is inked blue. The specimen is opened 1engthwise and sectioned and entire1y submitted in N1 and n2.. Part o. is further designated "3. Right obturator 1ymph node". Received fresh and placed in formalin is a 4 x 2.5  1.5 cm aggregate of lobulated yellow-tan Fibrofatty tissue. Sectioning for 1ymph node candidates reveais 5.Tymph node candidates ranging from 0.8-2.1 cm in greatest diameter. The specimen is entirely submitted as follows: 01: 3 lymph node candidates 02: One 1ymph node candidate 03-o4: one Tymph node candidate, sectioned 05 and 06: Remaining fibrofatty'tissue. Part P is further designated."16 round 1igament". Received fresh and placed in. formalin are 2 portions of fibroadipose tissue ranging from 1.7 x 1 x'0.3 cm to 0.9 x 0.7 x 0.3'cm. The specimen is' entirely submitted in p1. XX [], M.D., Ph.D Page 5
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diff --git a/output/text/73c15595-153e-43a9-b4b5-b2406952c0ff.txt b/output/text/73c15595-153e-43a9-b4b5-b2406952c0ff.txt
new file mode 100644
index 0000000000000000000000000000000000000000..89097e424db700c243bd235c9f10bb00bb6b7955
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+
+--- Page 1 ---
+Clinical Information HISTORY OF PRESENT ILLNESS Symptoms: Weight lss H emmtia Clinical Findings: Performance Scale (Karnofsky Score):  100 Asymptomatic 80-90 Symptomatic but Fully Ambulatory 60-70 Symptomatic,in bed less than 50% of day 40-50 Symptomatic, in bed more than 50% of day,but not bed ridden 20-30 Bed Ridden CURRENT MEDICATIONS Drug Dose Route Frequency Date (mm/dd/yyyy) To To / To / To / To
+
+--- Page 2 ---
+PAST MEDICAL HISTORY Diagnosis/Disease/Disorder/Injury Diagnosis Date Treatment Status Menopausal Status Pre-menopausal Peri-Menopausal Post-menopausal Birth Control:Condom Oral Contraceptive IUD  Hormone Replacement  Other: Therapy: SOCIAL HISTORY Occupation: Environmental Hazards: Smoking History Current Status TYPE Packs/day Duration When Quit YES NO yrs yr Alcohol Consumption Current Status TYPE Drinks/day Duration When Quit YES SNO yrs yr Drug Use Current Status TYPE Frequency Duration When Quit YES NO yrs yr FAMILYMEDICAL HISTORY Relative Diagnosis Age of Diagnosis LABDATA Test Result Test Result Date HIV Negative Positive: CEA Negative Positive: Hep B Negative  Positive: CA 15-3 Negative Positive: Hep C Negative Positive: CA 19-9 Negative Positive: AFP Negative Positive PSA Negative Positive: Other: Other: Negative Positive: Negative Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+DIAGNOSTIC STUDIES Study Results Date Ultrasound  A tmwut was foun in the lefkicneel X-Ray CT Endoscopy MRI Biopsy CLINICAL DIAGNOSIS Location of Suspected Involved Suspected Distant Metastasis Clinical Staging T3 NA Stage: Treatment Information SURGICAL TREATMENT Procedure Date of Procedure ReSeeton eft kidnau Primary Tumor Organ Detailed Location Size eLt Jcidney DemoR 3x 3x2 cm Extension of Tumor Lymph Nodes Description Location of Lymph Nodes # of Lymph Nodes Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Organ Detailed Location Size Surgical Staging T 3 NA M Stage: 0 NEOADJUVENT THERAPY (Chemo, Radiation, Immuno, Hormonal, or Molecular) Drug/Treatment Dose Route Frequency Date (mm/dd/yyyy) / To To / To / / / / / To / / / To / 3
+
+--- Page 4 ---
+SPECIMEN TYPE (#of samples provided) Frozen Paraffin Block Blood/Serum/Plasma Slide Diseased Normal Diseased Normal Diseased Normal Diseased Normal 2 4 2 2 Time to LN2 Time to Formalin Time to LN2 12 min 13 min min PATHOLOGICALDESCRIPTION Primary Tumor Organ Size Extension of Tumor Distance to NAT efT leidneylumor Rx3x2cm cm Lymph Nodes Location # Examined # Metastasized Distant Metastasis Organ Detailed Location Size Pathological Staging pT3 NA M Stage: TY Notes: 4
+
+--- Page 5 ---
+CELL DISTRIBUTION + Diffuse STRUCTURAL PATTERN XStreaming + Mosaic Storiform Necrosis Fibrosis Lymphocytic Infiltration X Palisading Vascular Invasion X Cystic Degeneration Clusterized Bleeding Alveolar Formation Myxoid Change Indian File Psammoma/Calcification 2.Cellular features: Squamous + Adenomatous + Sarcomatous + Lymphomatous Squamoid Cell Glandular cell X Round Cell Large Cell Spindle Cell Cell Stratification Fibroblast Small Cell Keratin Secretion Osteoblast RS CeIVRS Like Desmosome Intracyt.Vacuole Lipoblast Inflam.Cell Pearl Gland formation Myoblast Plasma Cell Otherwise Specified: D7R HeeRos Dr7J D320 Dy707 L 2.Cellular Differentiation: Well Moderately Poor 3.Nuclear Atypia: Nuclear Appearance II Aniso Nucleosis Hyperchromatism Nucleolar Prominent Y Multinucleated Giant Cell Mitotic Activity X Nuclear Grade
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diff --git a/output/text/73c36f00-7388-48fe-8c6d-9fa68354d181.txt b/output/text/73c36f00-7388-48fe-8c6d-9fa68354d181.txt
new file mode 100644
index 0000000000000000000000000000000000000000..904e1d23ddc6338fafb02c629a6bdeec75f3394d
--- /dev/null
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+--- Page 1 ---
+Page 2 1cs-0-3 Carciiomna, inhil trafing Lrbulev 85701 Site: breust, Nos c50.9 /27/ SUrgiCAL REPORt Name: Sex: F Pathology Number Date Collected: DOB: Location: Date Received: Doctor. M.R. Number: Account Numbe PRE-OPERATIVE DIAGNOSIS LEFt BREAST CANCER POST-OPERATIVE DIAGNOSIS LeFt BrEAst CAnCEr PROCEDURE LefT BREASt tOTAL MASTECTOMy WITH SENTInEL LymPh ODE BIOPSY, F.S. TISSUES A. LYMPH NODE (S) - LEFT SENTiNEL LYMPH NODE #1 *FS** B. LYMPH NODE (S) - LEFT SENTiNEL LYMPH NODE #2 **FS** C. BREAST MASTECTOMY (WMO) NODES - LEFT WRI TISSUE FS DIAGNOSIS A. Left Sentinel Lymph node #1, f.s. -- UUID:10DA3573-BD53-4579-AD90-E770CEF08498 TCGA-A2-A0YD-01A-PR NEgaTive (0/1). B. LEft SenTinel Lymph nOdE #2, f.S. -  NEGATIVE (O/1). {Reported to surgeon: Diagnosed by: FINAL DIAGNOSIS A. LEFT SENTINEL LYMPH NODE #1 - One (1) benign reactive RegiOnal Lymph nOde, nEgaTive fOr MALIGNANCY. B. LEft SEnTineL Lymph NODe #2 - One(1) benign REActive rEgiOnAL Lymph nODe, NEgatIve fOR MALIGNANCY. c. Left breast mastectomy - MOderately DifferenTiated infiltrating LoBular CarcinomA, 6.6 Cm., with FOC! OF LOBULAR CARCiNOMA iN-SITU INVOLVINg TERMINAL Ductules. SCARFF-BLOOM-RiChARDSON BREASt CANCER hIStOLOgIC SCORE 6 (3+2+1). ALl DEsIgnAteD InKeD SUrgical mArgins Are freE Of tumOR. Patlent Nam.. Pathology Number SURGICAL REPORT RECEIED Page 1 of 2
+
+--- Page 2 ---
+Page 3 Patlent Name: Pathology Numbt Pathologic tnm Stage:t3 pn0(+) mx, Stage iiB, g2, infiltrating LOBULAR CARCINOMA. pQRI CategORy II: 3260F. Diagnosed by Revlawad a nd alnctronlcaily signed out by:. COMMENT The Irnmunohistochemical stains on the first sentinel lymph node (specimen A) reveals seven positive cells with the Cytokeratin stain In the subcapsular space indlcating incidental microscopic micrometastases. The seven cells are in total measurements less than 0.1 mm. The second lymph node. (specimen B) is negative. No individua! positive cells seen.. GROSS DESCRIPTION The specimen is received In three separate containers labeled lesignated A, B, C.. A. The container Is recelved fresh unfixed labeled *left sentinel lymph node #1 for frozen section". The specimen consists of an ovoid mass of apparent fatty tissue which is 1 x 0.4 x 0.3 cm. in.  greatest overall dimenslon. Sectioning reveals a pink-tan firm nodule varying up to 0.4 cm. in greatest dimension. Touch prep and frozen section are obtained by Dr. specirmen including frozen section is submitted in two blocks.. The entire B. The contalner is received fresh untixed labeled *ieft sentinel lymph node #2 for frozen sectlon" and consists of an ovoid mass of apparent fatty tissue which is 0.4 x 0.3 x 0.3 cm. The specimen is bisected reveallna a thin rim of pink-tan firm tissue. Frozen section and touch prep are. obtained by The entire specimen including frozen section is submitted in two blocks. C. The container is received fresh unfixed labeled "left breast -- suture on upper outer quadrant" and consists of an 953 gm. apparent left breast which Is 23 x 20 x 5 cm. in greatest overall dimension. There is an attached suture indicatlng upper outer quadrant which is inked with yellow dye. The Jower outer quadrant is inked with an orange dye. The upper inner quadrant is Inked with red dye, and the lower inner is inked with green dye. Seriai sectioning reveals a firm tan-gray tumor mass which is 6.5 x 4.5 x 3 cm. in greatest overall dimension and grossly appears to be 2 cm. from the underlying resection line, 5.5 cm. from the lower outer quadrant, 7 cm. from the upper inner, 8 cm. from the lower Inner and 8 cm. from the upper outer. The speclmen Is submitted in  nine blocks. Key Note Block Summary:. 1--nipp!e, 2 through 4-- tumor, 5-- deep resection line, 6---upper  Inner, 7---upper outer, 8--- lower inner, 9-- lower outer. MICROSCOPIC EXAM  MICROSCOPiC EXAMINATION CONDUCTED 8Y PATHOLOGIST CONFIRMS FINAL DIAGNOSIS. SPECIAL STAINS PERFORMED: PanKeratin (specimens A &B) (CG) Patlent Name Pathology Number: -- SURGICAL REPORT Diagnosis ry Tumor Site Discrepancy Page 2 of 2 Cual/Sy.chronuus
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diff --git a/output/text/73e71ebf-3050-4209-9503-bd269caaed84.txt b/output/text/73e71ebf-3050-4209-9503-bd269caaed84.txt
new file mode 100644
index 0000000000000000000000000000000000000000..59d73279665d2b1f67429df65728b10785647fb2
--- /dev/null
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@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+TCGA-B9-4113 SURGICAL PATHOLOGY Diagnosis: A: Kidney, left,laparoscopic nephrectomy. Renal cell carcinoma,papillary type grade 2 (of 4, Furhman classification),5.8 cm diameter,extending into but not through capsule, without angiolymphatic invasion, surgical margins not involved. -Medullary fibromata,multiple. B:Testicle, right, orchiectomy. -Benign testicular parenchyma, mild decreased spermatogenesis, no neoplasm identified. C: Testicle, left, orchiectomy -Benign testicular parenchyma,mild decreased spermatogenesis, no neoplasm identified. Comment: None. Clinical History: Patient is with a clinical diagnosis of prostate carcinoma and a renal mass, in for left laparoscopic nephrectomy and bilateral orchiectomy. Gross Description: Received are three appropriately labeled containers. Container A is additionally labeled"left kidney." Specimen fixation: formalin Type of specimen: laparoscopic nephrectomy Size and weight of specimen: 650 grams,approximately 19x 11x5.2 cm nephrectomy specimen Presence/absence of adrenal gland: absent Tumor description: there is a well circumscribed soft yellow lower pole mass; the majority of the inner portion
+
+--- Page 2 ---
+of the mass is markedly hemorrhagic; there are no cysts or areas of calcification noted; the mass is in the medulla but is compressing the pelvis Tumor size:approximately5.8x4.0x2.9 cm Presence/absence of multicentricity: absent Confinement/Non-confinement to kidney: confined Extent of invasion: Perirenal adipose tissue: tumor does not grossly involve Renal vein: tumor does not grossly involve Ureter: tumor does not grossly involve Other organs: n/a Surgical margins: Perirenal adipose tissue: grossly negative Renal vein: grossly negative Renal artery: grossly negative Ureter:grossly negative Description of kidney away from tumor: The remainder of the kidney is pink/tan with a relatively distinct corticomedullary junction with a cortex measuring approximately0.6 cm, the medulla measuring approximately 1.3 cm; additionally,there are three firm, white nodules noted in the cortex up to 0.5 x 0.3 x0.3 cm;these nodules do not grossly resemble the main tumor mass. Lymph nodes (hilar): No hilar lymph node candidates are palpated. Tissue submitted for special investigations: A small section of tumor and normal tissue were given to Tissue Procurement. Block Summary: Al - ureter and hilar vascular margins A2 - tumor and adjacent kidney A3 - tumor and capsule, tumor and adjacent kidney A4,A5 -additional tumor A6 - representative from three firm white cortical nodules A7,A8 - representative normal kidney A9 - representative hilar fat A10 - additional possible ureter margin
+
+--- Page 3 ---
+Al1 -lymph node candidates Container B is additionally labeled "right testicle." It holds a 37.1 gram, 5.5 x 3.0 x2.5 cm testiclewith approximately3.5x 1.2 x 1.0 cm attached epididymis.The external surface of the testicle and the epididymis is tan, smooth and glistening. The external surface is inked blue to exhibit grossly unremarkable orange/pink, soft testicular parenchyma. The tunica vaginalis is approximately O.1 cm thick, intact and grossly unremarkable. The testicular parenchyma is grossly unremarkable. No masses or lesions are identified in either testicular or epididymal cut surfaces. Representative sections are submitted per block summary. B1 -spermatic cord margin B2-testicle B3 - testicle and epididymis Container C is additionally labeled "left testicle." It holds a 40.3 gram5x3.3x3.0 cm testicle with attached approximately 5.5 x2.0 cm epididymis.The external surface of both the testicle and epididymis is tan, smooth and glistening. The external surface is inked blue and the testicle is bivalved to exhibit orange/brown soft testicular parenchyma with no gross lesions or masses identified. The tunica vaginalis is intact and on average 0.1 cm thick. Sections are submitted as per block summary. C1 - spermatic cord margin C2 -testicle C3- testicle and epididymis Light Microscopy: Light microscopic examination is performed Histologic tumor type/subtype: renal cell carcinoma/papillary subtype Histologic grade if applicable grade2 of4,Furhman classification) Tumor size greatest dimension): grossly 5.8 cm diameter Extent of tumor invasion: Capsular invasion/perirenal adipose tissue: extension into
+
+--- Page 4 ---
+but not through capsule in block A3 Renal vein: not involved Ureter: not involved Blood vascular: not identified Lymphovascular: not identified Depth of invasion: Adjacent organs: no adrenal received Histologic assessment of surgical margins: negative Adrenal gland: not included Lymph nodes: none sampled Other significant findings: non-neoplastic kidney shows scattered medullary fibromata
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diff --git a/output/text/7416a76f-68a4-43c6-9bd8-c706370c24a3.txt b/output/text/7416a76f-68a4-43c6-9bd8-c706370c24a3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d86b86a53fd01e50131da0e8ff0046960fecc738
--- /dev/null
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+
+--- Page 1 ---
+524 1c0-0-3 Carcin0mn,infitfnaHNg duct,N0s 85oo/3 Site: bresst, Nis C50. 9 5/04/1 DIAGNOSIS (A) SENTINEL LYMPH NODE #1, LEFT AXILLARY: One lymph node, no tumor identitied (0/1).. Immunohistochemical stains tor cytokeratin are negative. (B).LEFT BREAST AND LOW AXILLARY CONTENTS, MASTECTOMY: TWO FOCI OF INVASIVE DUCTAL CARCINOMA OF BREAST, MODIFIED BLACK'S NUCLEAR GRADE 2-3 (INTERMEDIATE TO HIGH GRADE) LOCATED AT THE 1 O'CLOCK AND 2 O'CLOCK POSITIONS WHICH MEASURE 2.5 CM AND 1.5 CM IN GREATEST DIMENSION, RESPECTIVELY. Angiolymphatic invasion is not identitied.. EXTENSIVE DUCTAL CARCINOMA IN SITU (DCIS), MODIFiED BLACK'S NUCLEAR GRADE 3 (HIGH GRADE), SOLID AND CRIBRIFORM TYPES WITH NECROSIS AND ASSOCIATED MICROCALCIFICATIONS. DCIS IS 3 MM FROM THE SUPERFICIAL MARGIN ADJACENT TO THE 1 O'CLOCK TUMOR. INVASIVE CARCINOMA IS 6 MM FROM THE SUPERFICIAL MARGIN ADJACENT TO THE 1 O'CLOCK TUMOR. INVASIVE CARCINOMA AND DCIS ARE PRESENT AT THE SUPERFICIAL MARGIN ADJACENT TO THE 2 O'CLOCK TUMOR. DCIS IS LESS THAN 1 MM FROM THE DEEP MARGIN ADJACENT TO THE 2 O'CLOCK TUMOR. INVASIVE CARCINOMA IS 2 MM FROM THE DEEP MARGIN ADJACENT TO THE 2 O'CLOCK TUMOR. Five low axillary lymph nodes, no tumor identiftied (0/5). Nipple, no tumor identified. UUID:88292748-EB82-4155-A458-CF9F0E60336E Skin with seborrheic keratosis. TCGA-GM-A2DN-01A-PR Redacted SEE COMMENT. (C) LYMPH NODE, ADDITIONAL LOW LEFT AXILLARY, EXCISION: Three lymph nodes, no tumor identified (0/3).. (D) NEW SUPERIOR LATERAL MARGIN, EXCISION: Skin and breast tissue, surgical resection margins negative for invasive and in situ carcinoma. Seborrheic keratosis. See comment. (E) NEW SUPERFICIAL LATERAL MARGIN, EXCISION: Fibroadipose tissue, no tumor identified.. See comment. (F) NEW INFERIOR LATERAL MARGIN, EXCISION:
+
+--- Page 2 ---
+Small focus of an atypical ductal proliferation. Surgical resection margin, no invasive or in situ carcinoma identified. Skin, no tumor identified.. See comment. Entire report and diagnosis completed by COMMENT In the left mastectomy specimen, there is extensive DCIS which is associated with both foci of invasive carcinoma. The DCIS involves an area of breast tissue which is estimated to measure 7 to 8 cm. The two toci of invasive carcinoma are separated by approximately 2.0 cm of breast tissue which has foci of DCIS. There is a morphologic spectrum of DCIS ranging from low grade to high grade with necrosis. Both invasive carcinomas have an associated prominent lymphocytic response. The nuclear grade of the invasive carcinoma ranges from intermediate to high grade. The additional submitted margins and final margin status were discussed with Dr.. The additional submitted margins (specimens D-F) appear to cover the superficial aspect of both tumors.. Specimen  has skin and breast tissue and the true surgical resection margins (superior/lateral aspect of the specimen) are negative for invasive and in situ carcinoma. There are some glands at the deep aspect of this specimen which are most likely benign but are difficult to interpret due to cautery artifact. This area does not correspond to true surgical margin.. Specimen F has skin and breast tissue, and the true surgical resection margins (inferior/lateral aspect ot the specimen) are negative for invasive and in situ carcinoma. In this specimen, there is a small focus of a cauterized atypical ductal protiferation present at the superior edge of the specimen which does not represent true margin in this specimen. The differential diagnosis includes a small focus of residual DCiS, atypical ductal hyperplasia or secretory change with cytologic atypia. GROSS DESCRIPTION (A) LEFT AXILLARY SENTINEL LYMPH NODE #1, NOT BLUE, COUNT 9 - A single lymph node (1.5 x 1.0 x 0.5 cm). The specimen is serially sectioned and four touch preparations are performed. Entirely submitted in A1-A2.. *TP/DX: NO TUMOR IDENTIFIED. (B) LEFt BREASt, AXILLARY CONTENTS, SHORt STItCH AT 12 O'CLOCK - A radical mastectomy specimen measures 27.0 x 18.0 x 4.0 cm with an ellipse of skin (5.5 x 5.0 cm), unremarkable nipple (0.8 x 0.8 cm) and axillary contents (9.0 x 4.0 x 3.0 cm). The specimen is serially sectioned trom medial to lateral into 16 slices. The nipple is located on slice 7. Located at the outer upper quadrant, 1 o'clock, approximately 7.0 cm from the nipple is an ill-defined firm, white mass (2.5 x 2.0 x 1.8 cm). The mass is approximately 0.6 cm from the closest superior superficial margin. Another ill-defined firm area (1.5 x 1.3 x 1.2 cm) is interior to the first mass in the lateral aspect of the breast at approximately 2 o'clock. This lesion is approximately 2 cm from the 1 o'clock tumor, does not appear to be connected to the 1 o'clock tumor, and abuts the inferior superficial margin. There is an exophytic granular area on the skin surtace at about 11 o'clock, measuring 0.5 x 0.5 x 0.2 cm. The remainder of the specimen is unremarkable. The specimen is radiographed after slicing. The suspicious areas are marked by the radiologist. Multiple lymph nodes are identitied.. Representative section of the normal and tumor tissue are submitted for tumor bank. INK CODE: Blue - superior, orange - inferior, black - deep. SECTiON CODE: B1-B14, area with circled microcalcification/superior aspect of 2.5 cm tumor, the medial aspect (B1, B5 includes superior superficial margin; B3-B4, B12-B14, inferior portion), B15-B19, 2.5 cm mass (815, tumor with superior supericial margin; B16, tumor with deep margin; B17, tumor with superior superficial margin; B18-B19, tumor); B20, tissue between two lesions, no true margin in section; B21, 1.5 cm firm area with inferior superticial margin; B22-26, 2.5 cm tumor (B22, tumor with closest superior superticial margin, B23, tumor with deep margin, B24 with superior superticial margin, B25, with deep margin; B26, with superior superficial margin); B27, Superior aspect of 1.5 cm tumor; B28-B29: 1.5 cm lesion (B28 with superior superticial margin; B29, with deep margin) B30, inferior margin, perpendicular sections; B31-B33, 1.5 cm lesion with inferior superticial lateral margin; B34-B35, upper outer quadrant, B36-37, upper inner quadrant; B38-39, lower inner quadrant; B40,
+
+--- Page 3 ---
+lower outer quadrant; B41, nipple cross section; B42-B43, nipple perpendicular section; B44-B46, one lymph node serially sectioned (1.8 cm); B47, four lymph nodes; B48, one lymph node bisected (1.8 cm); B49, skin lesion.. (C) ADDITIONAL LOWER AXILLARY NODE, LEFT - Three lymph nodes ranging from 0.3 x 0.3 x 0.2 to 3.0 x 2.0 x 1.0 cm. SECTiON CODE: C1, one lymph node; C2, one lymph node trisected; C3-C5, one lymph node serially sectioned. (D) NEW SUPEROLATERAL MARGIN, SHORT STITCH SUPERIOR, LONG STITCH LATERAL - A yellow-tan irregular fragment of adipose tissue (7.5 x 5.0 x 1.7 cm) with an attached white-tan irregular fragment of skin (6.3 x 3.0 cm). The surface of the skin displays a raised flesh colored papule (0.3 x 0.4 x 0.2 cm) that is 0.6 cm from the superior aspect of the skin. The specimen is received oriented with a short stitch at the superior margin and a long stitch at the lateral margin. The specimen is inked, serially sectioned from lateral-to-medial and no gross lesions are identitied on the cut surface. Representative sections are submitted in D1-D3. INK CODE: Blue - superior; orange - inferior; black - deep. SECTION CODE: D1-D3, representative sections serially sectioned trom lateral-to-medial. : (E) NEW SUPERFICIAL LATERAL MARGIN, STITCH TRUE MARGIN - A yeilow-tan irregular fragment of fibroadipose tissue (4.5 x 4.3 x 1.1 cm). The specimen is received oriented with a stitch on the true margin. The true margin is inked in black, the specimen is serially sectioned and no gross lesions are found. Representative sections are submitted in E1-E4. (F) NEW INFERIOR LATERAL MARGIN, SHORT STITCH SUPERIOR, LONG STITCH LATERAL - A yellow-tan irregular agment of adipose tissue (8.9 x 4.8 x 1.9 cm) with an attached white-tan irregular fragment of skin (7.5 x 3.0 cm). The surface ot he skin is grossly unremarkable. The specimen is inked, serially sectioned and no gross lesions are found. Representative sections are submitted. INK CODE: Btue - superior; orange - inferior; black - deep. SECTION CODE: F1-F4, representative sections serially sectioned from lateral to medial.. LINICAL HISTORY Left breast cancer. SNOMED CODES T-04050, M-85003, M-85002 'Some tests reported here may have been developed and performance characteristics determined bye. These tests have not been specitically cleared or approved by the U.S. Food and Drug Administration.". Released by: ---END OF REPORT-.-.
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diff --git a/output/text/7435d295-45c1-4f2b-9292-5da196a60c2c.txt b/output/text/7435d295-45c1-4f2b-9292-5da196a60c2c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5219f1cc8b9f40797cbac343a413de5136798340
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+
+--- Page 1 ---
+UUID:476488A9-3708-4B11-854A-C918583C7804 TCGA-3L-A3YW-01A-PR Redactec LAS NO: CLINICAL INFORMATIONCOMMENTS: FEMALE . YEARS LoC:METRICS CANCER PR PATIENT CODF CONSULTANT: DATE :  Printed On : Hitopanglosy Slopay Smat Spocimon: Two blocks representing left breast tissue are received. Clinical Note: Carcinoma left breast. Mlcroscopic Features: One atf the block reveals breast tissue infiltrated by acetluiar neoplastic lesion composed of intermediate size tumor cells exhibiting moderate nuclear pieomorphism with eosinophilic cytoplasm. Mitotic figures are also identified. The surrounding stroma exhibits moderate chronic inflammation. Focal necrosis (< than 5%) is noted. The other biock reveals benign breast tissue. Conclusion: Two blocks representing left broast tissue received for 2nd opinion :- Infltrating LobularCarcinoma grade i! (Tubule formation 2/3, Nuclear pleomorphism 2/3, Mitoses 2/3. Total = (6/9), according to Modified Bloom and Richardson's grading system. Tumour nuclei constitute approximately 70% of the total nuckei. /c-0-3 earcii oma, iifiP+natmiy 1obul,no5 Dr. 853o/3 Srtu: brust, nos c5o.9 DSQULFIED
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diff --git a/output/text/74516cc7-66d0-429c-9c50-29a009972d91.txt b/output/text/74516cc7-66d0-429c-9c50-29a009972d91.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f710e79443cb58e1e17fe04a42f80c091ac22f36
--- /dev/null
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@@ -0,0 +1,24 @@
+
+--- Page 1 ---
+HX SURGICAL PATHOLOGY REPORT * Final Report * Document Type: UUID: 3B9E30D8-1671-465F-9425-951912C1ECF5 *Date - Date of Service: TCGA-XF-AAMG-01A-PR Redacted Document Status: Document Title: Encounter info: Contributor System: TOD D * Final Report * areensmsurstuleel Nos 812013 Sit: Modoler us5 ORDERING PHSYCIAN: Clo 7.9 Ordering Physician: PRE-OPERATIVE DIAGNOSIS: > 3/26|i4 Prostate cancer MICROSCOPIC DESCRIPTION: A-E: See final microscopic-diagnosis. F: Sections of the bladder and prostate show a poorly differentiated, invasive urothelial carcinoma. The tumor cells grow in trabeculae and display a high nuclear to cytoplasmic ratio and a high mitotic rate. Nuclear pleomorphism is moderate and nuclear irregularities are present. The chromatin is coarsely clumped with areas of irregular clearing with moderate to sparse eosinophilic cytoplasm. Cell borders are indistinct. Tumor cells deep invade the prostatic parenchyma approaching to within 0.1 cm of the inked prostatic capsular radial margin (F17). G-V: See final microscopic-diagnosis. Signature Line Signed by: ELECTRONIC SIGNATURE GROSS DESCRIPTION: A: The specimen is received fresh from the O.R. and labeled "Right uretheral margin" (sic). It consists of a 0.3 cm length of ureter 0.5 cm in diameter. Entirely submitted in one cassette for frozen section. B: The specimen is received fresh from the O.R. and labeled "Left uretheral margin' (sic). It consists of a 0.3 cm length of ureter 0.2 cm in diameter. Entirely submitted in one cassette for frozen section. C: The specimen is received fresh from the O.R. and labeled "Peritoneal mass." it consists.of a 3 x 3 x 0.7 cm, greasy, yellow to off white tissue fragment. Cut section reveals a iobular, green-yellow architecture with fine, white Printed by: Page 1 of 8 Printed on: (Continued)
+
+--- Page 2 ---
+HX SURGICAL PATHOLOGY REPORT * Final Report * streaks. Submitted in two cassettes, one cassette for frozen and two cassettes for permanent. D: The specimen is received fresh from the O.R. and labeled "Inferior urethral margin." It consists of a 0.4 x 0.4 x 0.2 cm, tan tissue fragment. Entirely submitted for frozen section. E: The specimen is received fresh from the O.R. and labeled "Posterior urethral margin." It consists of a 1 x 0.5 x 0.4 cm, tan tissue fragment. Entirely submitted for frozen section. F: The specimen is received fresh from the O.R. and labeled "Bladder & prostate." It consists of a 20 x 13.5 x 5.5 cm cystoprostatectomy specimen. The peritoneum measures 17 x 12 cm and is grossly uninvolved. The bladder measures 5 x 5 x 3 cm. The prostate measures approximately 2 3 x 3 x 3 cm to palpation but is firmly attached to a 5 x 4 x 3 cm, palpable mass at the neck of the bladder. The specimen is opened along its. anterior surface to reveal the following: A 5 x 4 x 3 cm, lobulated, exophytic mass that is located in the portion of the bladder inferior margin. A portion of the mass detached from the specimen upon opening. The surface of the mass displays stellate ulceration and necrosis. The mass is located at the interface between the bladder and the prostate. Serial section reveals a flat demarcation between the mass and the prostate. The cut surface of the mass is firm and white-tan and displays an interface with the prostate parenchyma. The prostatic parenchyma is not lobulated; however, fine, protruding, yellow-white, punctate areas are present in the right lobe of the prostate. The prostatic urethra measures 1.5 cm in length and is grossly involved. The verumontanum is excavated. The uninvolved bladder mucosa is purple and edematous. No other lesions are noted. The uninvolved wall is 0.6 cm in thickness. The maximum depth of invasion is 1.1 cm. The bladder wall thickness in the area of invasion cannot be measured as it occurs in the bladder neck. Representative sections are submitted in 25 cassettes (see summary). G: The specimen is received fresh from the O.R. and labeled *Posterior urethral margin." It consists of a 1.4 x 0.5 x 0.3 cm, tan tissue fragment. Entirely submitted for frozen section. H: The specimen is received fresh from the O.R. and labeled "Anterior urethral margin." It consists of a 1.4 x 1 x 0.6 cm, tan tissue fragment. Entirely submitted for frozen section. I: The specimen is received fresh from the O.R. and labeled "Lateral urethral margin." It consists of a 0.5 x 0.4 x 0.3 cm tissue fragment and a 0.7 x 0.4 x 0.3 cm tissue fragment. Entirely submitted for frozen section. J: The specimen is received in formalin and labelled "Right common iliac lymph nodes." It consists of a 2.2 x 2 x 0.7 cm aggregate of greasy, yellow tissue fragments. Entirely submitted in one cassette. K: The specimen is received in formalin and labeled "Right obturator lymph nodes." It consists of 7 x 3.5 x 1.4 cm of greasy, yellow tissue. Entirely submitted in five cassttes.. L: The specimen is received in formalin and labeled "Right internal iliac lymph nodes." It consists of 5 x 4 x 1 cm of greasy, yellow tissue fragments. Entirely submitted in three cassettes. Printed by: Page 2 of 8 Printed on: (Continued)
+
+--- Page 3 ---
+HX SURGICAL PATHOLOGY REPORT * Final Report * M: The specimen is received in formalin and labeled "Presacral lymph.nodes." It consists of a 4 x 3 x 1.5 cm of greasy, yelow tissue. Entirely submitted in one cassette. N: The specimen is received in formalin and labeled "Left obturator lymph nodes." It consists of a 5 x 2 x 0.8 cm of greasy, yellow tissue fragment. Entirely submitted in three cassettes. O: The specimen is received in formalin and labeled "Left external iliac lymph nodes." It consists of 5 x 5 x 1 cm. Of greasy, yellow tissue. Submitted in in three cassettes. P: The specimen is received in formalin and labeled "Right hypogastric lymph nodes." It consists of a 1.5 x 0.8 x. 0.5 cm, purple-tan tissue fragment. Entirely submitted in one cassette. Q: The specimen is received in formalin and labeled "Obturator vessel". It consists of a 1.5 x 1.2 x 0.5 cm of. portion of vascular tissue. Entirely submitted in a single cassette. R: The specimen is received in formalin and labeled "Left common iliac lymph nodes." It consists of a 1.5 x 1.5 x 0.5 cm, greasy, yellow tissue fragment. Entirely submitted in one cassette. S: The specimen is received in formalin and labeled "Left presciatic lymph nodes." It consists of a 2 x 0.7 x 0.3 cm, greasy, yellow tissue fragment. Entirely submitted in one cassette.. T: The specimen is received in formalin and labeled "Appendix." It consists of a vermiform appendix measuring 4.8 cm in length and 0.5 cm in diameter. The serosal surface is unremarkable with the exception of creeping fat reaction located from the tip to 1 cm proximal to the tip. Representative sections in one cassette. U: The specimen is received in formalin and labeled "Left proximal ureter." It consists of a 0.7 cm length of. ureter, 0.5 cm in diameter. Entirely submitted in one cassette. V: The specimen is received in formalin and labeled "Right proximal ureter." It conists of a 1.5 cm disrupted length of ureter, 0.4 cm in diameter. Entirely submitted in one cassette.. SECTIONS AFS: frozen section, right ureteral margin all embedded BFS: frozen section, left ureteral margin all embedded. CFS: frozen section, peritoneal mass C1,2: peritoneal mass DFS: frozen section, inferior urethral margin all embedded EFS: frozen section, posterior urethral margin all embedded F1: uninvolved bladder mucosa .F2: left ureterovesical junction Printed by: Page 3 of 8 Printed on: (Continued)
+
+--- Page 4 ---
+HX SURGICAL PATHOLOGY REPORT * Final Report * F3: right ureterovesical junction F4: left ureter F5: right ureter F6: additional section of uninvolved bladder mucosa. F7,8: right distal prostate with tumor F9: left distal prostate. F10,11: right mid anterior prostate with tumor F12: right mid posterior prostate F13-16: left mid anterior prostate with tumor F17: left mid posterior prostate F18-20: right proximal prostate arranged anterior to posterior F21-23: left proximal prostate arranged anterior to posterior F24; right seminal vesicle. F25: left proximal posterior prostate GFS: frozen section, posterior urethral margin all embedded HFS: frozen section, anterior urethral margin all embedded IFS: frozen section, lateral urethral margin all embedded J: right common iliac lymph nodes all embedded K1,2: single, palpable, right common iliac lymph node, multiple sections K3-5: remaining tissue L1-3: right internal iliac lymph nodes all embedded M: presacral lymph nodes all embedded N1,2: single left obturator lymph node N3: remaining tissue 0: left external iliac lymph nodes p: right hypogastric lymph nodes all embedded Q: obturator vessel all embedded R: Ieft common iliac lymph nodes all embedded. S: left presciatic lymph nodes all embedded T: appendix U: left proximal ureter all embedded v: right proximal ureter all embedded INTRAOPERATIVE DIAGNOSIS: FROZEN SECTION DIAGNOSIS: AFS:  Right ureteral margin: - no carcinoma in situ identified Printed by: Page 4 of 8 Printed on: (Continued)
+
+--- Page 5 ---
+HX SURGICAL PATHOLOGY REPORT * Final Report * BFS:Left ureteral margin: - no carcinoma in situ identified CFS: Peritoneal mass: - fat necrosis. DFS:  Inferior urethral margin:. - focus of carcinoma in situ in gland duct. EFS:  Posterior urethral margin:. - carcinoma in situ in periurethral glands GFS:  Posterior urethral margin:. - no carcinoma in situ HFS: Anterior urethral margin:  carcinoma in situ in periurethral glands IFS: Lateral urethral margin:. - no carcinoma in situ DIAGNOSIS COMMENT: On specimen D, the frozen section shows a focus of carcinoma in situ in a gland. This is not present on the permanent section. There is a low grade papillary urothelial carcinoma in the region of the bladder neck and mid region of the bladder.. A morphologically distinct high grade tumor arises in the bladder neck and prostatic urethra. This is a high grade tumor that invades the prostate and bladder neck. The low grade tumor is noninvasive.. FINAL DIAGNOSIS: RADICAL CYSTOPROSTATECTOMY, BILATERAL PELVIC LYMPH NODE DISSECTION, APPENDECTOMY: RIGHT URETERAL MARGIN (A): FROZEN SECTION DIAGNOSIS: - NO CARCINOMA IN SITU IDENTIFIED FINAL DIAGNOSIS:E - NO HIGH GRADE UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED LEFT URETERAL MARGIN (B): Printed by: Page 5 of 8 Printed on:. (Continued)
+
+--- Page 6 ---
+HX SURGICAL PATHOLOGY REPORT * Final Report * FROZEN SECTION DIAGNOSIS: - NO CARCINOMA IN SITU IDENTIFIED FINAL DIAGNOSIS: - NO HIGH GRADE UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED PERITONEAL MASS (C): FROZEN SECTION DIAGNOSIS: - FAT NECROSIS FINAL DIAGNOSIS: INFARCTED APPENDICES EPIPLOICAE INFERIOR URETHRAL MARGIN (D): FROZEN SECTION DIAGNOSIS: - FOCUS OF CARCINOMA IN SITU IN GLAND DUCT FINAL DIAGNOSIS: - UROTHELiAL CARCINOMA IN SITU IN A GLAND DUCT (SEE COMMENT) POSTERIOR URETHRAL MARGIN (E): FROZEN SECTION DIAGNOSIS: - CARCINOMA IN SITU IN PERIURETHRAL GLANDS FINAL DIAGNOSIS: - UROTHELIAL CARCINOMA IDENTIFIED BLADDER AND PROSTATE (F): BLADDER: - INVASIVE UROTHELiAL CARCINOMA, GRADE 4/4, WITH EXTENSION INTO PROSTATIC DUCTS. GLANDS. AND STROMA - URETERS AND PROSTATIC RADIAL MARGIN, FREE OF TUMOR PAPILLARY UROTHELIAL CARCINOMA, GRADE 2I4 (SEE COMMENT) - EJACULATORY DUCT AND SEMINAL VESICLE INVOLVEMENT IDENTIFIED - NO EXTENSION INTO PERIPROSTATIC SOFT TISSUE IDENTIFIED TUMOR PRESENT WITHIN LYMPHOVASCULAR SPACES - THE NON-NEOPLASTIC PROSTATE SHOWS BENIGN GLANDULAR AND STROMAL HYPERPLASIA - NO HIGH GRADE PROSTATIC INTRAEPITHELIAL NEOPLASIA OR PROSTATIC ADENOCARCINOMA IDENTIFIED - NO TUMOR SEEN IN TWO PERIVESICAL LYMPH NODES POSTERIOR URETHRAL MARGIN (G): FROZEN SECTION DIAGNOSIS: Printed by: Page 6 of 8 Printed on: (Continued)
+
+--- Page 7 ---
+HX SURGICAL PATHOLOGY REPORT * Final Report *. - NO CARCINOMA IN SITU IDENTIFIED FINAL DIAGNOSIS: - NO HIGH GRADE UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED ANTERIOR URETHRAL MARGIN (H): FROZEN SECTION DIAGNOSIS:  CARCINOMA IN SITU iN PERIURETHRAL GLANDS FINAL DIAGNOSIS: - UROTHELIAL CARCINOMA IN SITU IN PERIURETHRAL GLANDS LATERAL URETHRAL MARGIN (I): FROZEN SECTION DIAGNOSIS - NO CARCINOMA IN SITU FINAL DIAGNOSIS: - NO HIGH GRADE UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED RIGHT COMMON ILIAC LYMPH NODES (J): - NO EVIDENCE OF MALIGNANCY IN THREE LYMPH NODES EXAMINED (0/3) RIGHT OBTURATOR LYMPH NODES (K): - NO EVIDENCE OF MALIGNANCY IN FOUR LYMPH NODES EXAMINED (0/4) RIGHT INTERNAL ILIAC LYMPH NODES (L) - NO EVIDENCE OF MALIGNANCY IN NINE LYMPH NODES EXAMINED (0/9) PRESACRAL LYMPH NODES (M): - NO EVIDENCE OF MALIGNANCY IN 12 LYMPH NODES EXAMINED (0/12) LEFT OBTURATOR LyMPH NODES (N): - NO EVIDENCE OF MALIGNANCY IN FOUR LYMPH NODES EXAMINED (0/4) LEFT EXTERNAL iLIAC LYMPH NODES (O): - NO EVIDENCE OF MALIGNANCY IN FOUR LYMPH NODES EXAMINED (0/4) RIGHT HYPOGASTRIC LYMPH NODES (P): - NO EVIDENCE OF MALIGNANCY IN TEN LYMPH NODES EXAMINED (0/10) OBTURATOR VESSEL (Q): - NO SIGNIFICANT PATHOLOGIC CHANGE - NO EVIDENCE OF MALIGNANCY Printed by:. Page 7 of 8 Printed on:. (Continued)
+
+--- Page 8 ---
+HX SURGICAL PATHOLOGY REPORT * Final Report * LEFT COMMON ILIAC LYMPH NODE (R): - NO EVIDENCE OF MALIGNANCY IN ONE LYMPH NODE (0/1) LEFT PRESCiATIC LYMPH NODES (S): - NO EVIDENCE OF MALIGNANCY iN TWO LYMPH NODES EXAMINED (0/2) APPENDIX (T): : DISTAL LUMINAL OBLITERATION - NO FURTHER SIGNIFICANT PATHOLOGIC CHANGE LEFT PROXIMAL URETER (U): - BENIGN URETER WALL, NO MUCOSA - NO EVIDENCE OF MALIGNANCY RIGHT PROXIMAL URETER (V): - BENIGN URETER - NO EVIDENCE OF MALIGNANCY PATHOLOGIC TNM STAGE: pT4aNOMX [NO TUMOR SEEN IN 51 LYMPH NODES (0/51)] Completed Action List: Printed by:  Page 8 of 8 Printed on: (End of Report) 110401
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diff --git a/output/text/7456f466-4113-464b-ada8-631161449b75.txt b/output/text/7456f466-4113-464b-ada8-631161449b75.txt
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index 0000000000000000000000000000000000000000..688111ba0bb88f44fcf37161584ab63284cba380
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+Page 1 of 6 UUID:00D2C4D3-B209-4854-992D-54E8048415BA TCGA-XF-AAN2-01A-PR Redactedd DIAGNOSIS: RADICAL CYSTOPROSTATECTOMY, PELVIC LYMPH NODE DISSECTION, URINARY DIVERSION AND GASTROSTOMY TUBE PLACEMENT: RIGHT DISTAL URETER (A) : FROZEN SECTION DIAGNOSIS: FINAL DIAGNOSIS: BENIGN URETER .NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED ICD o3 LEFT DISTAL URETER (B): FROZEN SECTION DIAGNOSIS:  NO HIGH GRADE ATYPIA OR TUMOR IDENTIFIED @rceromanerothileal NO$ FINAL DIAGNOSIS: 8lq0l3 BENIGN URETER NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED RIGHT EXTERNAL ILIAC LYMPH NODE (C): FROZEN SECTION DIAGNOSIS: Y 3|2 6|4p BENIGN FINAL DIAGNOSIS:  NO MALIGNANCY IDENTIFIED IN TWO LYMPH NODES EXAMINED (O/2) URETHRAL MARGIN (D) :) FROZEN SECTION DIAGNOSIS: NO HIGH GRADE ATYPIA OR TUMOR IDENTIFIED  FINAL DIAGNOSIS:  BENIGN URETHRA AND PERIURETHRAL TISSUE NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED BLADDER/PROSTATE (E) Pw Tss. glanduler'= s0?o, $ Sguamous = 267 BLADDER: INVASIVE POORLY DIFFERENTIATED UROTHELIAL CARCINOMA WITH SQUAMOUS AND GLANDULAR FOCI (3 X 2.5 X 1.6 CM), GRADES 3 AND 4/4, EXTENDING INTO DEEP MUSCULARIS PROPRIA AND APPROACHING BUT NOT INVOLVING PERIVESICAL SOFT TISSUE NO LYMPHOVASCULAR SPACE INVASION IDENTIFIED ADDITIONAL RANDOM MUCOSA INCLUDING TRIGONE/BLADDER, NECK, NO UROTHELIAL DYSPLASIA OR CARCINOMA IN SITU (FLAT LESION) IDENTIFIED RESECTION MARGINS, FREE OF UROTHELIAL DYSPLASIA AND MALIGNANCY PROSTATE: BILATERAL MODERATELY DIFFERENTIATED PROSTATIC ADENOCARCINOMA, GLEASON'S SCORE 6 (3+3),: CONFINED TO PROSTATE WITHOUT INVOLVEMENT OF CAPSULE OR PERIPROSTATIC SOFT TISSUE MULTIFOCAL HIGH GRADE PROSTATIC INTRAEPITHELIAL NEOPLASIA (PIN II AND III)S PROSTATIC URETHRA, NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED BILATERAL SEMINAL, VESICLES, FREE OF MALIGNANCY RESECTION MARGINS FREE OF MALIGNANCY AND UROTHELIAL DYSPLASIAS RIGHT PARACAVAL LYMPH NODES (F) :  NO MALIGNANCY IDENTIFIED IN TWO LYMPH NODES EXAMINED (0/2) LEFT PARA-AORTIC LYMPH NODES (G) : NO MALIGNANCY IDENTIFIED IN ONE LYMPH NODE EXAMINED (0/1) RIGHT COMMON ILIAC LYMPH NODES (H) :
+
+--- Page 2 ---
+Page 2 of 6 NO MALIGNANCY IDENTIFIED IN EIGHT LYMPH NODES EXAMINED (O/8) LEFT COMMON ILIAC LYMPH NODES (I):  NO MALIGNANCY IDENTIFIED IN FIVE LYMPH NODES EXAMINED (0/5) ADDITIONAL RIGHT EXTERNAL ILIAC LYMPH NODES (J) :  NO MALIGNANCY IDENTIFIED IN EIGHT LYMPH NODES EXAMINED (O/8)) RIGHT LYMPH NODE OF CLOQUET (K) :  NO LYMPH NODES OR MALIGNANCY IDENTIFIED (O/O) [ENTIRELY SUBMITTED] RIGHT OBTURATOR/HYPOGASTRIC LYMPH NODES (L) : NO MALIGNANCY IDENTIFIED IN TWELVE LYMPH NODES EXAMINED (O/12)) LEFT EXTERNAL ILIAC LYMPH NODES (M) : NO MALIGNANCY IDENTIFIED IN TEN LYMPH NODES EXAMINED (O/10) LEFT LYMPH NODE OF CLOQUET (N): NO MALIGNANCY IDENTIFIED IN ONE LYMPH NODE EXAMINED (O/1) LEFT OBTURATOR/HYPOGASTRIC LYMPH NODES (O) : NO MALIGNANCY IDENTIFIED IN SEVENTEEN LYMPH NODES EXAMINED (O/17) RIGHT PRESCIATIC LYMPH NODES (P): NO LYMPH NODES OR MALIGNANCY IDENTIFIED (O/O) [ENTIRELY SUBMITTED] PRESACRAL LYMPH NODES (Q): NO MALIGNANCY IDENTIFIED IN THREE LYMPH NODES EXAMINED (0/3) LEFT PRESCIATIC LYMPH NODES (R): NO LYMPH NODES OR MALIGNANCY IDENTIFIED (O/O) [ENTIRELY SUBMITTED] ADDITIONAL LEFT PARA-AORTIC LYMPH NODES (S): NO MALIGNANCY IDENTIFIED IN SIX LYMPH NODES EXAMINED (0/6) RIGHT PROXIMAL URETER (T): BENIGN URETER NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED LEFT PROXIMAL URETER (U) : BENIGN URETERS NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED LYMPH NODE SUMMARY: NO MALIGNANCY IDENTIFIED IN TOTAL OF 73 LYMPH NODES EXAMINED (0/73) PATHOLOGIC TNM STAGE: BLADDER: pT2bN0MX PROSTATE: pT2bN0MX (AJCC- 1997) Electronically signea by Verified: COMMENT: Representative sections of invasive carcinoma are submitted for p53 assay by.
+
+--- Page 3 ---
+Page 3 of 6 immunohistology, results of which will be issued in an addendum report. SPECIMEN SOURCE: A: "Right distal ureter F/Sn B: "Left distal ureter F/S" C: "Rt. external iliac lymph node". D: nUrethral margin" E: "Bladder/prostate" F: "Right para caval lymph nodes" G: "Left para aortic lymph nodes" H: "Right common iliac lymph nodes" I: "Left common iliac lymph nodes" J: "Additional right external iliac lymph nodes" K: "Right lymph node of cloquet" L: "Right obturator/hypogastric lymph nodes" M: "Left external iliac lymph nodes" N: "Left lymph node of cloquet" O: "Left obturator/hypogastric lymph nodes# P: "Rt. presciatic lymph nodes". Q: "pre sacral lymph nodes" R: "Left pre sciatic lymph nodes" S: "Additional left para aortic lymph nodes" T: "Right proximal ureter" U: "Left proximal ureter" CLINICAL INFORMATION: Pre-Op Dx: Bladder tumor Post-Op Dx: Same as pre-op GROSS EXAMINATION: A:  The specimen is received fresh from the O.R. and labeled "Right distal ureter F/s". It consists of a single segment of ureter measuring 0.2 cm in length and 0.4 cm in diameter.  The specimen is entirely submitted for frozen section diagnosis in AFS. B: The specimen is received fresh from the O.R. and labeled "Left distal ureter F/s". It consists of a portion of ureter measuring 0.2 cm in length and 0.4 cm in diameter. The specimen is entirely submitted for frozen section diagnosis in BFs.. C:  The specimen is received fresh from the O.R. and labeled "Rt. external iliac lymph node".. It consists of two lymph nodes measuring in aggregate 1 x 0.5 x 0.3 cm.  One lymph node is bivalved and and the second one is left intact. Both lymph nodes are entirely submitted for frozen section diagnosis in crs. D The specimen is received fresh from the O.R. and labeled "urethral margin". It consists of one fragment of tan tissue measuring 1 x 0.5 x 0.3 cm. The specimen is entirely submitted for frozen section diagnosis in DFs. E: The specimen is received fresh from the O.R. and labeled "Bladder/prostate". It consists of a radical cystoprostatectomy specimen measuring 29.5 x 11 x 3.4 cm.. A flap of peritoneal fat is present measuring 27.5 x 11:6 by iess than 0.1 cm. The peritoneal surface is smooth and glistening. The bladder itself measures 6.2 x 5 x 3.6 cm.  The resection margin and prostate are inked black with red ink superimposed on the right side.  The bladder is then opened along the anterior prostatic urethra and bladder wall. The uninvolved bladder wall measures 1.1 cm in thickness. Opening the bladder reveals an ulcerated mass lesion abutting the right ureterovesical junction. The lesion measures 3 x 2.5 x 1.6 cm.. The mass extends. into the deep muscle of the bladder wall but does not penetrate the surrounding soft tissue grossly.. It extends into the ureterovesical junction over a distance
+
+--- Page 4 ---
+Page 4 of 6 Colecteo Orderedb Of 1.s cm.  No other lesion is identified and the remaining bladder mucosa appears grossly unremarkable. The attached ureters are identified and opened..  The right ureter measures 10.9 cm in length and 1 cm in circumference. The left attached ureter measures 4.2 cm in length and 0.6 cm in circumference.  Both ureters are grossly unremarkable except for the tumor involvement of the right uvJ previously mentioned. The prostate measures 5.3 x 3.2 x 2.6 cm. The left seminal vesicle measures 4 x 1.7 x 0.8 cm, and the right seminal vesicle measures 3.6 x 1.6 x 0.8. cm.  The prostatic urethra measures 2.5 cm in length and 2.7 cm in circumference. There is no excavation present.  The mucosal surface is pink-tan and grossly unremarkable. The verumontanum measures 1 x 0.5 x 0.2 cm. The prostate is serially sectioned. No discrete lesion is identified grossly. Representative sections are submitted in 23 cassettes.. F: The specimen is received in formalin and labeled "Right para caval lymph nodes". It consists of a segment of adipose tissue measuring 2 x 1 x 0.4 cm. Entirely submitted in one cassette. G: The specimen is received in formalin and labeled "Left para aortic lymph nodes". It consists of a single segment of adipose tissue measuring 4.5 x 2 x 0.6 cm. Entirely submitted in two cassettes.. H: The specimen is received in formalin and labeled "Right common iliac lymph nodes".  It consists of multiple fragments of adipose tissue measuring 3 x'2.6 x. 0.6 cm in aggregate. Entirely submitted in two cassettes. I: The specimen is received in formalin and labeled "Left common iliac lymph nodes".  It consists of multiple fragments of adipose tissue measuring 5.5 x 4.6 x 1.2 cm in aggregate. Entirely submitted in four cassettes. J: The specimen is received in formalin and labeled "Additional right external iliac lymph nodes". It consists of multiple fragments of adipose tissue measuring 10.4 x 5.6 x 1.5 cm in aggregate. Entirely submitted in eight cassettes. K: The specimen is received in formalin and labeled "Right lymph node of cloquet".. It consists of a single segment of adipose tissue measuring 1.2 x 0.5 x 0.4 cm. Entirely submitted in one cassette.. L: The specimen is received in formalin and labeled "Right obturator/hypogastric. lymph nodes". It consists of multiple fragments of adipose tissue measuring 8.5 x 4.6 x 1.6 cm in aggregate. Entirely submitted in eight cassettes. M: The specimen is received in formalin and labeled aLeft external iliac lymph nodes". It consists of multiple fragments of adipose tissue measuring 6.7 x.4.46 x 1.2 cm in aggregate. Entirely submitted in six cassettes. N: The specimen is received in formalin and labeled "Left lymph node of cloquet" It consists of a single segment of adipose tissue measuring i.6 x 1 x 0.4 cm. Entirely submitted in one cassette.. 0: The specimen is received in formalin and labeled "Left obturator/hypogastric lymph nodes". It consists of multiple fragments of adipose tissue measuring 9.2 x 4.6 x 1.2 cm in aggregate. Entirely submitted in nine cassettes. P  The specimen is received in formalin and labeled "Rt. presciatic lymph nodes". It consists of multiple fragments of adipose tissue measuring 3.1 x 1 x 0.9 cm in aggregate.  Entirely submitted in one cassette.. Q: The specimen is received in formalin and labeled "pre sacral lymph nodes". It consists of multiple fragments of adipose tissue measuring 5.5 x 3 x 1.2 cm in aggregate. Entirely submitted in four cassettes..
+
+--- Page 5 ---
+Page 5 of 6 R: The specimen is received in formalin and labeled Left pre sciatic lymph nodes".  It consists of multiple fragments of adipose tissue measuring 2.2 x 1.6 x 0.5 cm in aggregate. Entirely submitted in one cassette. S: The specimen is received in formalin and labeled "Additional left para aortic lymph nodes". It consists of multiple fragments of adipose tissue measuring 2.5 x 2 x 1.6 cm in aggregate. Entirely submitted in three cassettes.. T: The specimen is received in formalin and labeled "Right proximal ureter". consists of a portion of ureter measuring 1 cm in length and o.9 cm in diameter. There are two metallic clips present..  The clips are removed and the specimen is. entirely submitted in one cassette. U The specimen is received in formalin and labeled "Left proximal ureter". It consists of a portion of ureter measuring 0.9 cm in length and 0.4 cm in diameter. There are two metallic clips present.  The clips are removed and the specimen is serially sectioned and entirely submitted in one cassette.. SECTIONS: AFs: frozen section, right distal ureter BFS: frozen section, left distal ureter CFs: frozen section, right external iliac lymph node DFS: urethral margin E1: bladder/prostate; right ureterovesical junction and tumor E2 : tumor E3,4: one tissue slice, bisected full thickness, showing tumor with inked. margin. E5-7: tumor E8: anterior bladder E9: dome E10: posterior bladder wall Eli: left lateral bladder wall E12: left ureterovesical junction E13: trigone and bladder neck E14: right prostatic apex E15: left prostatic apex E16: right anterior mid prostate E17: right posterior mid prostate. E18: left anterior mid prostate E19: left posterior mid prostate E20: right anterior proximal prostate E21: right posterior proximal prostate E22: left anterior proximal prostate E23: left posterior proximal prostate F: right paracaval lymph nodes - - all embedded G1,2: left para-aortic lymph nodes - all embedded H1,2: right common iliac'lymph nodes - all embedded 11-4: left common iliac lymph nodes - all embedded J1-8: additional right external iliac lymph nodes - all embedded. K: right lymph node of cloquet - all embedded L1-8: right obturator/hypogastric lymph nodes - all embedded M1-6: left external iliac lymph nodes - all embedded N: left lymph node of cloquet .  all embedded 01-9: left obturator/hypogastric lymph nodes P: right presciatic lymph nodes - all embedded Q1-4: presacral lymph nodes - all embedded R: left presciatic iymph nodes - all embedded. S1-3: additional left para-aortic lymph nodes  - all embedded T: right proximal ureter - all embedded.
+
+--- Page 6 ---
+Page 6 of 6 INTRAOPERATIVE FROZEN CONSULTATION: AFS: Right distal ureter:.  no high grade atypia or tumor identified BFs: Left distal ureter:  no high grade atypia or tumor identified cFs: Right external iliac lymph node:.  benign DFS: Urethral margin:  no high grade atypia or tumor identified MICROSCOPIC EXAMINATION:  A-D: See final microscopic-diagnosis. E: Sections of the bladder show high grade invasive urothelial carcinoma (E1-3, 5-7), grades 3 and 4/4, extending into the deep muscularis propria. The tumor approaches without involving perivesical soft tissue. Lymphovascular space. invasion is not identified.  Additional random sections of the bladder show no. urothelial dysplasia or malignancy.  All resection margins are free of both dysplasia and malignancy.  Sections of the prostate show prostatic adenocarcinoma (E16,18,19,23), Gleason's score 6 (3+3). The tumor is confined to the prostate. There are multiple foci of high-grade prostatic intraepithelial neoplasia (pIn II and III) present.  The seminal vesicles and all resection margins are free of malignancy and urothelial dysplasia.. F-U: See final microscopic -diagnosis.. W 3hy\y ancy
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diff --git a/output/text/745741a1-386d-4d75-ae22-6eb088a58e72.txt b/output/text/745741a1-386d-4d75-ae22-6eb088a58e72.txt
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index 0000000000000000000000000000000000000000..61d5b45a4936fb1120125474c670c2b886d4cae2
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+DlAgnosis:  Kidney, right "mass" (excision): Renal cell carcinoma, papillary Type I. Incipient lesions are present, see Note.. NOTE: Immunohistochemical staining for CK7 is negative The immunoperoxidase tests performed here were developed and their performance characteristics determined by the Specialized  They have not been cleared or approved by the U.s. Food and Drug Administration. -DA has also determined that such clearar  or approval is not necessary. This laboratory is certified under the Clinical Laboratory Improvement Armendments of (CLIA) as qualified to perform high complexity clinical laboratory testing. CLINICAL INFORMATION: Brief Clinical History: with right renal mass. Specimen. Taken For. Yes Allocate Order to Protocol:. PROcEDuRE: Operative Findings: right renal mass Post-Operative Diagnosis: right renal mass Pre-Operative Diagnosis: right renal mass SPECIMENS SUBMITTED: 1. KIDNEY, RIGHT, Renal mass GROSS DESCRIPTION: Received is a container labeled with the patient's name, medical record number, and "rt renal mass'. The specimen is a partially encapsulated mass with a rim of renal parenchyma measuring 7.5 x 6 x 3.5 cm. The specimen is inked in black. Sectioning reveals a tan, soft cut surface with an eccentric red area with yellow area in it. Approximately 1 x 0.9 x 0.3 cm in aggregate of tumor tissue is procured for (tumor nodule measures 2.5 cm in largest dimension). Procurement was performed by After fixation, the tumor measures approximately 6.5 x 4.5 x 3.3 cm. Representative sections are taken and submitted in 8 white cassettes labeled. for permanent processing (2 pieces in E, 2 pieces in H, 2 pieces in I). Patient Identificatinn. Page 1 of 2
+
+--- Page 2 ---
+Patient Identification Page 2 of 2
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diff --git a/output/text/748a80e1-64dc-4d60-8054-71c4fcde907e.txt b/output/text/748a80e1-64dc-4d60-8054-71c4fcde907e.txt
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index 0000000000000000000000000000000000000000..d3e21f89719c10e2195267007287d17cadad9b63
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+--- Page 1 ---
+Left bruat 1ca-0-3 13|8]10 8500|3 Srt Crd; brast, Nos c50.9 TSS: SPECIMENS: A. LEFT AXILLARY NON SLN #1 B. RIGHT AXILLARY SLN #1 C. RIGHT BREAST D. LEFT BREAST E. LEFT AXILLARY CONTENTS SPECIMEN(S): A. LEFT AXILLARY NON SLN #1 UUID:744919EA-D97A-41A1-B1F3-70A2F972D9A7 B. RIGHT AXILLARY SLN #1 TCGA-E2-A15A-01A-PR C. RIGHT BREAST Redacted D. LEFT BREAST E. LEFT AXILLARY CONTENTS INTRAOPERATIVE CONSULTATION DIAGNOSIS: TPA-left axillary non-sentinel lymph node #1: Positive for carcinoma.. TPB-right axillary Sentinel lymph node #1: Negatyve for carcinoma. Diagnoses called by Dr. to Dr. at GROSS DESCRIPTION: A. LEFT AXILLARY NON SLN #1  Received fresh labeled with the patient's identification and "left axillary non-sentinel lymph node #1" is a 1.3 x 1.1 x 0.4 cm lymph node. Bisected, a touch prep is performed, and specimen is submitted entirely in cassette A1. B. RIGHT AXILLARY SENTINEL LYMPH NODE #1 Received fresh labeled with the patient's identification and "right axillary Sentinel lymph node #1" is a 1.2 x 1.1 x 0.5 cm lymph node. It is bisected; touch prep is performed, submitted entirely in cassette B1. C. RIGHT BREAST Received fresh labeled with the patient's identification and "right breast" is an oriented 243 g, 16 x 15 x 12 cm mastectomy with 5 x 2.5 cm skin ellipse and 1.7 cm everted nipple. Ink code: anterior/superior-blue, anterior/inferior- orange, posterior-black. Specimen is serially sectioned into 11 slices from medial to lateral with nipple in slice 4 revealing a 1.5 x 1.3 x 1.2 cm biopsy site located in the upper outer quadrant, 0.4 cm from the deep margin and less than 0.1 cm from the anterior margin. Representatively submitted: C1: slice 3, upper inner quadrant C2: slice 5, upper inner quadrant C3: slice 7, upper outer quadrant C4: slice 10, upper outer quadrant C6-C8: slice 11, upper outer quadrant (biopsy site). C7: slice 9, lower outer quadrant. C8: slice 8, lower outer quadrant C9: slice 4, lower inner quadrant. C10: slice 2, lower inner quadrant. C11-C12: nipple, perpendicular sections C13: skin and nipple D. LEFT BREAST Received fresh labeled with the patient's identification and "left breast" is an oriented 359-g, 15 x 13.5 x 3 cm  mastectomy with 9.5 x 3.7 cm skin ellipse and 1.4 cm everted nipple. Ink code: Anterior/superior-blue, anterior/inferior-orange, posterior-black. Specimen is serially sectioned into 11 slices from lateral to medial with nipple in slice 5 revealing 3 lesions: 1) 4 x 3.5 x 3 cm firm stellate mass in the upper inner quadrant slices 6-9 that is closest to the anterior margin at 1.1- cm. 2) 1.5 x 1.2 x 1 cm firm nodule in the upper outer quadrant in slice 1 which is 0.8 cm from the deep margin and 5.7 cm lateral to lesion #1 3) 1.4 x 1.2 x 1.1 cm nodule in the lower outer quadrant in slice 1 which is less than 0.1-cm from the anterior margin and 1.6 cm inferior to lesion #2 Tissue is procured. Representatively submitted: D1: slice 1, upper outer quadrant (nodule 2). D2: slice 1, tissue connecting nodule 1 to nodule 2 D3: slice 1, lower outer quadrant (nodule 3) D4: slice 2, posterior mid D5: slice 3, mid section D6: slice 4, mid section D7: slice 5, mid section posterior to nipple.
+
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+D8: slice 6, section (mass) D9: slice 7, mass and posterior margin D10-D13: mass including margins, en bloc. D14: slice 9, mass D15: slice 10, medial to mass D16: slice 6, upper outer quadrant D17: slice 3, lower outer quadrant D18: slice 4, upper outer quadrant. D19-D20: perpendicular sections of nipple and skin E. LEFT AXILLARY CONTENTS Received fresh labeled with the patient's identification and "left axillary contents" is an aggregate of yellow-tan soft. tissue, 7 x 5 x 2.2 cm. Multiple lymph nodes are identified with firm pink-tan cut surfaces. Lymph nodes are. submitted entirely. E1-E2: 6 lymph nodes each E3-E8: 1lymph node each E9-E10: 1 lymph node, bisected E11-E12: 1 lymph node, bisected DIAGNOSIS: A. LYMPH NODE, SENTINEL #1, LEFT AXILLA, EXCISION: - METASTATIC CARCINOMA TO ONE OF ONE LYMPH NODE (1/1)., MEASURING 0.8-CM WITH NO EXTRANODAL EXTENSION. B. LYMPH NODE, SENTINEL #1, RIGHT AXILLA, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1). C. BREAST, RIGHT,MASTECTOMY:  - MULTIPLE FOCI OF LOBULAR CARCINOMA IN SITU  - FLAT EPITHELIA ATYPIA AND ATYPICAL DUCTAL HYPERPLASIAE - BIOPSY SITE CHANGES WITH FIBROSIS - MULTIPLE RADIAL SCARS, FIBROCYSTIC CHANGES WITH FIBROSIS, COMPLEX SCLEROSING ADENOSES AND APOCRINE METAPLASIA, AND MICROCALCIFICATIONS IN DUCTAL EPITHELIUM, NO DCIS OR  INVASIVE CARCINOMA IDENTIFIED - SEE NOTE D. BREASTLEFT, MASTECTOMY: - MULTIPLE FOCI OF INVASIVE DUCTAL CARCINOMA, SBR GRADE 2, LARGEST FOCUS MEASURING 4.O-CM - INTERMEDIATE NUCLEAR GRADE, DUCTAL CARCINOMA IN SITU, SOLID AND CRIBRIFORM TYPES WITH CENTRAL NECROSIS AND MICROCALCIFICATIONS - INVASIVE TUMOR PRESENT AT ANTERIOR INFERIOR SURGICAL RESECTION MARGIN - BIOPSY SITE CHANGES WITH FIBROSIS - SEE SYNOPTIC REPORT. E. LYMPH NODES, LEFT AXILLARY CONTENTS, AXILLARY DISSECTION:E - METASTATIC CARCINOMA TO TWELVE OF EIGHTEEN LYMPH NODES (12/18), LARGEST MEASURING 2.2 CM WITH EXTRANODAL EXTENSION NOTE: E-Cadherin is positive in the ADH focus and negative in the LCIS. Drs. and concur on presence of ADH in the right breast. SYNOPTIC REPORT - BREAST Specimens Involvedd Specimens: A: LEFT AXILLARY NON SLN #1 D: LEFT BREAST E: LEFT AXILLARY CONTENTSE Specimen Type:e Mastectomy Needle Localization:. No Laterality: I Left .  Invasive Tumor:e Present Multifocality: Yes WHO CLASSIFICATION Invasive.ductal.carcinoma, NOs 8500/3 Tumor size:  4cm Margins: Involved at Anterior-inferior Extent:: 1-cm
+
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+Tubular Score: 3 Nuclear Grade: 2 Mitotic Score: 1 Modified Scarff Bloom Richardson Grade:. Necrosis: Absent Vascular/Lymphatic Invasion: Present Extent: extensive Lobular neoplasia: LCIS Lymph nodes: Sentinel lymph node and axillary dissection Lymph node status: Positive 13 / 19 Extranodal extension DCIS present Margins uninvolved by DCIS DCIS Quantity:Estimate 10% Solid DCIS Type: Cribriform  DCIS Location:Associated with invasive tumor Nuclear grade: intermediate Necrosis: Present ER/PR/HER2 Resuits ER: Positive PR: Positive HER2: Negative by FISH Performed on Case:. Pathological staging (pTN): pT 2 N 3a CLINICAL HISTORY: None given PRE-OPERATIVE DIAGNOSIS: Left breast cancer. ADDENDUM: Specimen A was incorrectly designated in the diagnosis field as "LYMPH NODE, SENTiNEL #1, LEFT AXiLLA, EXCISION"; the correct designation of the specimen is "LYMPH NODE, NON-SENTINEL #1, LEFT AXILLA, ExCisiON." Only the specimen description is changed, the diagnosis remains the same. Microscopic/Diagnostic Dictation: Pathologist, ' Final Review: Pathologist,  Final: Pathologist, Addendum Review: Patnoiogist, 1. Addendum Final: Pathologist,
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diff --git a/output/text/7495496a-82f0-4fbb-b842-d9bb219da346.txt b/output/text/7495496a-82f0-4fbb-b842-d9bb219da346.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fcddcbf73b94e0cf0fa381601ca6de9505084997
--- /dev/null
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@@ -0,0 +1,15 @@
+
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+ UUID: 581088D6-9F9C-4572-B61D-BAF0F6C79B2F Redacted TCGA-C8-A8HP-01A-PR Clinical Case Report RDC3 8s7s/3 St DBusrtnos 05.9 8 Cs,4 s-Jn/zr|3 Informed Consent I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator Signature Date Clinical Information GENERAL INFORMATION Date of Birth (mm/dd/yyy) Height Marital Status Race Temperature  Single XMarried SETNAMEE Gender Weight  Divorced  Widow Blood Pressure Heart Rate  Male. Female HISTORY OF PRESENT ILLNESS Chief Complaints: A tm9uf mIe LeffheaXHj Peu`nfiL Symptoms: A-lwnp wcy SouneT in-the cwrpif Clinical Findings: Performance Scale (Karnofsky Score):  100 Asymptomatic   80-90 Symptomatic but Fully Ambulatory 60-70 Symptomatic, in bed less than 50% of day  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden  20-30 Bed Ridden CURRENT MEDICATIONS Drug Dose  Route Freguency Date (mm/dd/yyyy) / To 1 To / 1 To 1 To / To
+
+--- Page 2 ---
+PAST MEDICAL HISTORY Diagnosis/Disease/Disorder/Iniury  Diagnosis Date Treatment Status OB/GYN HISTORY Menopausal Status Date of First Menses # of Pregnancies  Pre-menopausal. O 3  Peri-Menopausal Date of Last Menses # of Live Births - Post-menopausal Birth Control:  Condom  Oral Contraceptive  IUD  Hormone Replacementd  Other: Therapy: SOCIAL HISTORY Occupation: Environmental Hazards: Smoking History Current Status TYPE Packs/day Duration When Quit  yes NO (yrs) (yr) Alcohol Consumption. Current Status TYPE Drinks/day Duration When Quit  YES p NO (yrs) (yr) Drug Use Current Status Type Freguency Duration When Quit  yES $NO (yrs) (yr) FAMILY MEDICAL HISTORY Relative Diagnosis Age of Diagnosis LAB DATA Test Result Date Test Result Date HIV  Negative  Positive: CEA  Negative  Positive: Hep B sPNegative  Positive: CA 15-3  Negative  Positive: Hep C Negative  Positive: CA 19-9   Negative  Positive: AFP  Negative  Positive: PSA  Negative  Positive: Other: Other:  Negative  Positive:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+DIAGNOSTIC STUDIES Study Results Date Ultrasound X-Ray CT Endoscopy MRI Biopsy  Cevei nomo CLINICAL DIAGNOSIS Preoperative Clinical Diagnosis L. BReast-Coucer Location of Suspected Involved Lymph Nodes. Location of Suspected Distant Metastasis. Clinical Staging Date of Dlagnosis T2 N2 MO Stage: 1L A Treatment Information SURGICAL TREATMENT Procedure Date of Procedure Modi bed Dadical mmastetoan. Primary Tumor d Organ Detailed Location Size Left heeast Jmer CDnes cxer Qeadnan3 x2sx 2 cm Extension of Tumor Lymph Nodes Description Location of Lymph Nodes # of Lymph Nodes Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Organ Detailed Location  Size Surgical Staging. T 2 N ? mo Stage: IA NEOADJUVENT THERAPY (Chemo, Radiation, Immuno, Hormonal, or Molecular) Drug/Treatment Dose Route Frequency Date (mm/dd/yyy) / To 1 / To 1 / To / 1 To 1 1 1 To / 1 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by: ... Date: _Time: Preserved by: -- Date: Iime: SPECIMEN TYPE (# of samples provided) Frozen Paraffin Block Blood/Serum/Plasma  Slide Normal Diseased Diseased Diseased Diseased Normal Normal Normal 2 2 2 2 2 Time to LN2 Time to Formalin Time to LN2 15 min min min PATHOLOGICAL DESCRIPTION Primary Tumor Organ Size Extension of Tumor Distance to NAT LRetbxeersT ZiumeR 3 x2 S x 2 cmupR culeR9re42!T 6 cm Lymph Nodes Locatlon # Examined # Metastasized Distant Metastasis Organ Detailed Locatlon Size Pathological Staging N z m o Stage: 4 pT z Notes: gnybo noteg 9 ( pe;7ive 6) NeQat've 5 4
+
+--- Page 5 ---
+Consolidated Pathology Diagnosis Cell Distribution + Structural Pattern +  Diffuse  Streaming  Mosaic Y  Storiform  Necrosis Flbrosis Lymphocytic Infiltration. X  Palisading  Vascular Invasion Cystic Degeneration Clusterized Bleeding. Alveolar Formation  Myxoid Change Indian File  Psammoma/Cakcification Squa mous Adenomatous + Sarcomatous - +  Lymphomatous Squamold Cell Glandular cell K  Round Celt  Large Cell Spindle Cell Cell Stratification x Fibroblast Small Cell Keratin Secretion Osteoblast  RS Cell/RS Like  Desmosome X Intracyt. Vacuole Y  Lipoblast Inflam. Cell Pearl Gland formation X Myoblast  Plasma Cell Cellular Differentiation:  Well  Moderate  Poor Nuclear Atypla: 0 1 II III  Aniso Nucleosis 4 Hyperchromatism  Nucleolar Prominent y Muitinudeated Giant Celld Mitotic Activity Nuclear Grade: D,5o7,j7r367,D3 4tJ. Dq 3O7 Jeeso8R Final Pathology Repor! Melexaehe Mp e (Adeustearxdrse CzRebr Comments: M- Nr: CaRe:nMametat<s}e8 Ao LN Date Director, Research Pathology ht. Criteria Diagnosis Discrepancy INTEGRATED REPORT OF FINDINGS BY COLLABORATORS AND 'ATHOLOGISTS Primary Tumor Site Discrepancy HPAA Discrepancy Prior Malignancy History Dual/Sync! us Primary N QUALIFIED
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diff --git a/output/text/74ab53b9-3e2c-4381-aafc-fb09da735436.txt b/output/text/74ab53b9-3e2c-4381-aafc-fb09da735436.txt
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index 0000000000000000000000000000000000000000..dac55cde8db96249a5dd7d57ca74759a4500d825
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+PATIENT HISTORY: CHIEF COMPLAINT/ PRE-OP/ POST-OP DIAGNOSIS: Left renal cell carcinoma. PROCEDURE: Nephrectomy, complete. SPECIFIC CLINICAL QUESTION: Not anSwered. OUTSIDE TISSUE DIAGNOSIS: Not answered.  PRIOR MALIGNANCY: Not answered. UUID:462D07AA-748E-4758-A432-989274226745 CHEMORADIATION THERAPY: Not answered. TCGA-B1-A47M-01A-PR Redacted ORGAN TRANSPLANT: Not answered. IMMUNOSUPPRESSION: Not answered. OTHER DISEASES: Not answered. SPECIMEN(S) RECEIVED: 1. left kidney ADDENDUM This is an addendum to report the results of Immunostaining: The neoplastic cells are positive for racemase, CK7, CA9 (focal) and CD10 (focal). Overall, these immunohistochemical  Staining profile is consistent with a paplllary renal cell carcinoma with clear cell features.. Our final diagnosls remains unchanged.. 7 50% c1taw cU Fustu, pur fSs. FINAL DiAGNOSIS: Part 1: Kidney, left, radical nephrectomy- A.  PApIlLAry RenAL Cell CArcinOmA, TYpe 2 WITh CLEaR CELl FEAtureS. (See Comment).e B. FUHRMAN GRADE 3/4. C. TumOR mEasures 4.5 X 4.0 X 3.5 CM. D. Tumor invades the peri-renal adipose tissue. E. Tumor DOes NnOt InVolVe tHe gErOta's fASCiA. ALL MARGINS ARE NEGATIVE F G. TUMOR TO CLOSEST INKED PARENCHYMAL MARGiN IS LESS THAN 0.1 CM.  NO VASCULAR INVASION IS IDENTIFIED. H PATHOLOGIC STAGE pT3a Nx Mx. COMMENT: Immunostains are pending to further characterize this tumor, and the results will be reported in an addendum.. ics-0-3 8340|3 Sifx : Kidnuy,NOs Cb4.9
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diff --git a/output/text/74acde75-6b7c-4a95-a0ad-8b0f8a898571.txt b/output/text/74acde75-6b7c-4a95-a0ad-8b0f8a898571.txt
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index 0000000000000000000000000000000000000000..1d3ac7c17322ca5fd6ad9c3b92ebe56fd6d42176
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+
+--- Page 1 ---
+Ics-0-3 adinoCarciiomL N0s 81yo|3 Sit: sigmnid (pw cQcF) C18.7 hw 3/29|u Sample ID #: Diagnosis: Resectate of the large intestine under inclusion of a centrally ulcerated, poorly differentiated adenocarcinoma of the colorectal type and of max. 4.5 cm in diameter, with broad infiltration of the pericolic fatty tissue, extensive lymphangiosis carcinomatosa and thirty-two regional lymph node metastases. Tumor-free large intestinal resection margins. Tumor-free mesenteric resection margin. Tumor stage: pT3 pN2 (32/40) pMX; G3; L1, V0, RX Redacted
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diff --git a/output/text/74d30c4f-ae57-44af-aeac-63ab97e91259.txt b/output/text/74d30c4f-ae57-44af-aeac-63ab97e91259.txt
new file mode 100644
index 0000000000000000000000000000000000000000..90a64bbfc02f25ba4f6b7356f8defc33e3daf2de
--- /dev/null
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+
+--- Page 1 ---
+ UUID:FFCA27E4-3A1F-4626-AB67-2DE62CAD713F TCGA-HQ-A2OE-01A-PR Redacted Sample Type Tumour Primary Sample Preparation Fresh Frozen Site of Primary (Event) Bladder 1cs-0-3 Site of Tissue Year of Sample Collection carcion,urothihal, Nos 8130f3 Age at Sample Collection (yrs) Sample Comments Srt: b/iddw, N05 C t79 Days to Procedure Date 0 Days to Diagnosis 15 Type of Procedure Surgical resection 9114/4 Site of Primary (Histology) urinary bladder Bilateral Disease Tumour Size (cm) 3 Histology papillary urothelial carcinoma Grade/Differentiation Grade X (Unknown) Pathological T T2a Pathological N N2 Number of Nodes Sampled Number of Nodes Positive Clinical M MX Histology Comments
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diff --git a/output/text/74db6a08-95e3-43c0-9663-772a20628eeb.txt b/output/text/74db6a08-95e3-43c0-9663-772a20628eeb.txt
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index 0000000000000000000000000000000000000000..7dadb7e8e01af3d7ced33917ec5669f34e063ccd
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:54EFE89F-32E0-4E95-A841-728648D9D11E TCGA-OR-A5K1-01A-PR Redacted PREVIOUS DIAGNOSIS INQUIRY REPORT DATE: PAGE #: SEx M BIRTHDATE: ADMDATE: OPER DATE: PROCEDURE: APMI ADDITIONAL REPORT FOLLOWING ADDITIONAL SECTIONS AND IMMUNOHISIOCHEMISTRY: Please see diagnosis below. PROCEDURE: APDXE 1. Adrenal gland, left, resection: Adenocortical carcinoma, low-grade by mitotic activity, with capsular and vascular invasion. Ki-67 proliferation marker shows a proliferation rate above that typically found in benign tumors. See COMMENT. rCim IcD 03 COMMENT : This adrenocortical neoplasm has a very low mitotic activity as assessed by counting of mitotic figures. The Ki-67 proliferation marker shows a proliferation rate that is consistent with the diagnosis of low grade adrenocortical carcinoma. In addition, research immunostains show a similar proliferation rate using topoisomerase 2-alpha. Furthermore, the tumor shows. diffuse nuclear immunoreactivity for cyclin E which is also consistent with a. diagnosis of carcinoma. (These research stains are not performed by a. certified Tab and therefore are not billed to the patient. : signing staff pathologist, have personally 83767 es from this case.. He 1/30/13 "This test was developed and its performance characteristics determined by the. linical Immunoperoxidase Laboratory. It has not been cleared or approved by the U.s. Food and Drug Adninistration. (The FDA has. determined that such clearance is not necessary. This test is used for lwi 4/12/13 PAA Discrepancy r Site Dis
+
+--- Page 2 ---
+PREVIOUS DIAGNOSIS INQUIRY REPORT DATE: PAGE#: SEX: M BIRTHDATE: PAT TYP-. ADM DATE: OPER DATE: clinical purposes. It should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 ("clia"] as qualified to perform high complexity testing)." OPER DATE: PROCEDURE: SPHS year-old male with left adrenal mas.. PROCEDURE: SPGD 1. "Left adrenal" Received fresh in a medium container is a 110 gram adrenal with a scant amount of attached yellow adipose, 7.9 x 6.2 x 5.7 cm. The cut soft, well-circumscribed tumor. The tumor has focal areas of bright-yellow necrosis occupying approximately 15% of the cut surface. Tunor abuts the margin. A 1.1 x 2.3 x 0.5 cm segments of normal adrenal gland is present. NO other abnormalities are noted. Photographs have been taken.. 1A&B. Tumor to normal. 1C-G. Tumor to capsule. : 1H. Normal adrenal. PROCEDURE: SPDX 1. Adrenal gland, left, resection: Adrenocortical carcinoma, low-grade by mitotic activity, with capsular invasion. Additional report pending additional sections and immunohistochemistry.. .the signing staff pathologist, have personally. examined and interpreted the slides from this case..
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diff --git a/output/text/74f8c4a8-7776-472b-86a1-b8243538a70d.txt b/output/text/74f8c4a8-7776-472b-86a1-b8243538a70d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8accbd98f0ffeecb9fe43eaf9eed8e8104da5f55
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+
+--- Page 1 ---
+atlehlt Name. Accession # Med. Rec. #: Date of Procedure: DOB: Date of Receipt: Gender: Date of Report: Ref. Physician: Account #: Patient Address: Billing Type: Additional Copy to: Ref. Source: TCGA-BP-5173 Clinical Diagnosis & History: Specimens Submitted 1: SP: Right renal tumor ( 2: SP: Deep margin #2 () DIAGNOSIS: 1) KIDNEY, RIGHT; PARTIAL NEPHRECTOMY: - RENAL CELL CARCINOMA, CONVENTIONAL TYPE. NUCLEAR GRADE I/IV. - THE PATTERN OF GROWTH IS ACINAR. - THE TUMOR GREATEST DIAMETER IS 2.O CM.  - THE TUMOR IS CONFINED WITHIN THE RENAL CAPSULE./I - NO INVASION OF THE RENAL VEIN IS IDENTIFIED. - THE TUMOR IS LESS THAN 1 MM FROM THE SURGICAL MARGIN. - THE NON-NEOPLASTIC KIDNEY SHOWS PATCHY LYMPHOCYTIC INFILTRATE. - THE ADRENAL GLAND IS NOT SUBMITTED. 2) FAT, DEEP MARGIN; BIOPSY: - BENIGN FIBROADIPOSE TISSUE. TATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL). AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. *** Report Electronically Signed Out * Gross Description:. 1) The specimen is received fresh for frozen section diagnosis, labeled, "Right renal tumor (stitch marks deep margin)". It consists of a 5.0 x 3.5 x 2.5 cm tan-red renal tissue with a 2.0 x 2.0 x 2.0 cm tan-yellow tumor mass. Grossly the tumor mass extends to less than 0.1 cm to the nearest resection margin. Grossly the margin is free.. The uninvolved renal cortical tissue is unremarkable. Also received is attached perirenal fat, measuring in aggregate 5.0 x 2.0 x 2.0 cm and is grossly unremarkable. The specimen is representatively submitled. Summary of Sections: FSCA -- frozen section control A FSCB -- frozen section contol B TU- tumor  R -- uninvolved kidney Page 1 of 2
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT 2) The specimen is received fresh for frozen section diagnosis, labeled, "Deep margin #2".  It consists of a tan-yellow soft tissue measuring 0.8 x 0.3 x 0.2 cm. Entirely frozen. Summary of Sections: F$C  frozen section control Summary of Sections: Part 1:" SP: Right renal tumor Block Sect. Site PCs 1 fsc 1 1 fscb 1 1 1 2 tu 2 Part 2: SP: Deep margin #2 Block Sect. Site PCs fsc 1 Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the Intraoperative. consultation, 1A-B) FROZEN SECTION DIAGNOSIS: RENAL CORTICAL NEOPLASM. NEGATIVE RESECTION MARGIN. PERMANENT DIAGNOSIS: SAME. 2) BENIGN. FROZEN SECTION DIAGNOSIS: PERMANENT DIAGNOSIS: SAME. Page 2 of 2 END OF REPORT
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diff --git a/output/text/75371c39-83ff-4793-8bbe-cf533799ae46.txt b/output/text/75371c39-83ff-4793-8bbe-cf533799ae46.txt
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index 0000000000000000000000000000000000000000..cb0eb2be67a9bbd76e8a0fc02a253cc5658edf73
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+--- Page 1 ---
+UUID:44D82403-023E-455C-94DC-2D5FFB25D305 CGA-3U-A98F-01A-PR Redacted tcD o-3 Sample Mwoloms,byphasgi Gender: Male 983b3 malonait DOB: Race: White Report Date: fJ3112114j Tissue Procurement Date:. Pathology Report:. Surgical Pathology Report FINAL PATHOLOGIC DIAGNOSIS A. Right chest wall mass; biopsy: - Skeletal muscle and fibroadipose tissue with reactive changes and acute and chronic inflammation. B. R4 lymph node; biopsy:. - Two lymph nodes, no tumor. C. Number 7 lymph node; biopsy: - Seventeen lymph nodes, no tumor. D. Pleural peel; resection:. - Malignant biphasic tumor most consistent with biphasic mesothelioma. Thoracic Mesothelioma Pathologic Parameters Pleura/Pericardium, Resection MACROSCOPIC Specimen Type: Pleural resection Tumor Site: Right pleura Tumor Configuration and Size: Diffuse, maximum thickness: 18.5 cm MICROSCOPIC Histologic Type: Biphasic mesothelioma (90% sarcomatoid, 10% epithelioid Tumor Extension Into but not through diaphragm Endothoracic fascia Venous/Lymphatic (Large/Small Vessel) Invasion (V/L): Absent Margins: Cannot be assessed *Pathologic Staging (pTNM): pT3, N0 Primary Tumor (pT): pT3: Tumor (locally advanced but potentially resectable) involves any of the ipsilateral pleural surfaces, with at least 1of the following: invasion of the endothoracic fascia, invasion into mediastinal fat, solitary completely resectable focus of tumor invading the soft tissues of the chest wall, non-transmural involvement of the pericardium
+
+--- Page 2 ---
+Regional Lymph Nodes (pN): pN0: No regional lymph node metastasis *Effective January 1, 2010 this Checklist utilizes the 7th edition TNM staging. system for pleural mesothelioma of the American Joint Committee on Cancer (AJCC) and the International Union Against Cancer (UICC). Comment This is a biphasic tumor. The majority of the stromal component is highly. cellular with spindle-type hyperchromatic cells that frequently overlap with one another. There is focally more fibrotic stroma. The spindle cell component extends into polypoid masses that are covered with single layer of epithelioid. cells. The epithelioid cells are cuboidal to columnar with well-defined cell borders and clear-to-eosinophilic cytoplasm. This is not classic for mesothelioma. Therefore the differential diagnosis including synovial sarcoma solitary fibrous tumor, carcinosarcoma, metastatic renal cell carcinoma and malignant peripheral nerve cell tumor was considered. Immunohistochemistry (controls appropriate): Epithelioid component and focally the sarcomatoid component are positive for calretinin, WT-1, cytokeratin. (CAM 5.2), EMA, CAIX, Bcl2, D2-40, CK5/6. Sarcomatoid component is focally positive for SMA with very weak focal positivity for TLE-1. There is very focal epithelial positivity for MOC31. Tumor is negative for MIC2, Chromogranin, Pax8,. Desmin, BerEP4, CEA, Beta-Catenin, Synaptophysin, TTF-1, CD34 and S-100. Because the morphology is suggestive of synovial sarcoma, the specimen was. sent for genetic testing for t(x,18) which was negative. The official report is included below.. Overall, although the morphology is slightly unusual for mesothelioma, and. the loss of keratin staining in a large part of the sarcomatoid tumor is also unusual, positivity for other mesothelial markers (calretinin, WT-1, CAIX, and. D2-40) supports this diagnosis. Dr. [] has reviewed the case and concurs with the diagnosis. RECEIVED FROM xxxxxxxxxxxxxx xx/xx/ Pleural peel (xxxxxx ,xx/xx/ : No or fusion transcript was detected by RT-DNA amplification.. [], M.D. Procedure Notes: Molecular Oncology Number: xxxxxx Specimen Type: Paraffin embedded unstained slides RT-DNA amplification for Synovial Sarcoma Fusion Transcript. Assay No: XXXXXX
+
+--- Page 3 ---
+ORIGINAL REPORT ON FILE IN SURGICAL PATHOLOGY LABORATORY xxxx [] M.D. Interpretation performed by the Attending Pathologist and reviewed with the Resident/Fellow, [] MD, PhD Electronically Signed Out by [] M.D. Clinical History: The patient is a  -year-old male with malignant spindle cell neoplasm undergoing pleurectomy, decortication, thoracotomy.. Specimens Received: A: Right chest wall mass. B: R4 lymph node C: Number 7 D: Pleural peel Gross Description: The specimens are received in four containers each labeled with the patient's name and medical record number. A. The first container is additionally identified as, "right chest wall mass". Received fresh and placed in formalin are 4 soft, rubbery, pink-tan tissue fragments measuring 6.0 x 4.8 x 1.6 cm in aggregate, all of which are serially sectioned and representative section submitted as A1 and A2.. B. The second container is additionally identified as, "R4 lymph node" Received fresh and placed in formalin are 2 soft, yellow-tan tissue fragments measuring 4.5 x 1.2 x 0.8 cm and 1.0 x 1.1 x 0.3 cm which are submitted entirely as follows: B1-B2: One lymph node candidate, bisected, a one half in each cassette B3: 2 lymph node candidates C. The third container is additionally identified as, "#7". Received fresh and placed in formalin are multiple soft, rubbery, pink-tan tissue fragments measuring 2.7 x 4.5 x 0.9 cm in aggregate are submitted entirely as follows:. C1: 2 lymph node candidates, bisected C2: 5 lymph node candidates C3: 2 lymph node candidates C4: 5 lymph node candidates C5: One lymph node candidate, bisected. C6: One lymph node candidate, bisected. D. The fourth container is additionally identified as, "right pleural"
+
+--- Page 4 ---
+Received fresh and placed in formalin is a right pleurectomy specimen with a volumetric measurement of 1250 ml. The specimen is received in 2 large portions, a tumor mass and a pleura with multiple thickened areas, with a combined weight of 1105 gm. The tumor mass measures 18.5 x 18.5 x 11.0 cm and the thickened pleura measures 18.0 x 17.0 x 0.9 cm. According to the requisition form, there is a stitch designating the diaphragm, which is identified. The diaphragm measures 16.0 x 11.0 cm and the abdominal surface of the diaphragm is inked blue. At this site, the tissue is rubbery, firm, tan. There is no adherent pericardium. The parietal pleura is thickened, white-tan, nodular, rubbery, fibrotic and is intact surrounding the lung. 90% of parietal pleura received is encased in firm, yellow-gray tumor nodules measuring up to 5.8 x 2.1 cm located predominantly along the anterolateral aspect of the chest. The visceral and parietal pleura are thickened up to 0.7 cm and fused. The diaphragmatic margin is actively involved with tumor and tumor is within 0.2 cm of the inked resection margin.. Block Summary: D1-D5: diaphragm margin D6-D7: sections of largest pleura tumor deposits D8-D12: tumor abutting visceral surface/side D13-D17: Tumor abutting the chest wall D18-D21: sections from thickened pleura D22: thickened piece of adipose tissue XXX [], MD, PhD
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diff --git a/output/text/7544af64-1df8-44c3-8664-f41d5c486cde.txt b/output/text/7544af64-1df8-44c3-8664-f41d5c486cde.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9c8e3fcf54061f8b128ba271429edb8d55b92c2d
--- /dev/null
+++ b/output/text/7544af64-1df8-44c3-8664-f41d5c486cde.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TCGA #:  Internal Sample ID: Diagnosis: The present material involves an invasive, poorly differentiated carcinoma (G 3) with penetration of all wall layers (corresponding to at least p T 3) and with lymph and blood vessel invasion (L 1, V 1), as well as free lymph nodes and free resection margins.. /cs -o-3 Path Npot-Carcmoma,Nos 801of3 Provisional tumor classification: cQCF_adinrcucirmr, n^vs 8140f3 p T at least 3, p N 0, M X, R 0. hw 3f3ofn SrH: cecum (pw c4cF) C18.0 Confirmation of the epithelial nature by demonstration of what is known as total keratin Marked S100 protein positivity. In addition, positive reaction for chromogranin, focally also synaptophysin.. The findings therefore point to a neuro-endocrine carcinoma in the area stated. UUID:11E660AD-07D5-4996-A054-5F5 Redacted
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diff --git a/output/text/7560b26f-5c85-4d2d-997c-9b9b0c704e22.txt b/output/text/7560b26f-5c85-4d2d-997c-9b9b0c704e22.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6c83c8aec44b90c5522278f37a361fc7b867505c
--- /dev/null
+++ b/output/text/7560b26f-5c85-4d2d-997c-9b9b0c704e22.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1es-0-3 Cascimma,mfi1trntny duct Nos 850of3 UUID:69007BC0-E1DF-4E68-BA6A-352F6A12F233 TCGA-D8-A27N-01A-PR Redacted Site; hrast, Nos C50.9 lws 5/1f11 page 1 / 1 copy No. 5 Date: Examination: Histopathological examination Internal invoice No. Value of diagnostic procedure Examination Nc Patient: XXX PEseL: XXX Age. - Gender: F Material: Multiple organ resection -- right breast? Unit in charge: 1  Physician in charge: Material collected on Material received on: Expected time of examination: up to 8 working days Clinical diagnosis: Cancer of the right breast - status post biopsy, contents of the right axillary cavity. Examination performed on: Macroscopic description: Right breast.$ized 20 x 17.5 x 6 cm removed without axillary tissues and with a skin flap of 15.5 x 5 cm. Weight 1200 8. Tumour sized 3.0 x 3.2 x 2.5 cm found in the upper outer quadrant, located 4 cm from the upper boundary, 0.8 cm from the base and 1.3 cm from the skin. Microscopic description: Carcinoma ductale invasivum - NHG2 (3 + 2 + 2/16 mitoses/10 HPF - visual area: 0.55mm). Foci of carcinoma ductale in situ Dcis found within and outside the tumour (solid and cribrate type with medium and high nuclear atypia, comedo necrosis and calcinations, 40% of the tumour). Glandular texture showing parenchymal atrophy AXILLARY LYMPH NODES: Lymphonodulitis reactiva (No II). Histopathological Diagnosis: Carcinoma ductale invasivum et ductale in situ. Invasive ductal carcinoma and carcinoma in situ of the right breast.! Metastases carcinomatosae in lymphonodis axillae (No IV/xIx) (NHG2, pT2, pN2a). dr Compliance validated by: dr
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diff --git a/output/text/75724d69-b97c-4bbc-b29b-9ec96a8b4015.txt b/output/text/75724d69-b97c-4bbc-b29b-9ec96a8b4015.txt
new file mode 100644
index 0000000000000000000000000000000000000000..cc57ece1d6358240e00e901faece9426d3ab4445
--- /dev/null
+++ b/output/text/75724d69-b97c-4bbc-b29b-9ec96a8b4015.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:B644AEB6-7D46-4D4D-BA00-D42BCDDCB164 TCGA-A7-A426-01A-PR Redacted Final Surgical Pathology Report Procedure: Diagnosis A. Lymph nodes, right axillary sentinel nodes, resection:. 2 of'3 lymph nodes contain metastatic lobular carcinoma (2/3). B. Lymph node, left axillary sentinel node, resection:.  Single lymph node negative for metastatic carcinoma (0/1). C. Breast, right, simple mastectomy: Invasive lobular carcinoma. The nipple, overlying skin and deep margin of the mastectomy are free of carcinoma.  Fibrocystic changes with ductal hyperplasia and lobular carcinoma in situ. Post-biopsy changes are present. Breast, left, simple mastectomy: Invasive lobular carcinoma. The nipple, overlying skin and deep margin of the mastectomy are free of carcinoma. Fibrocystic changes with ductal hyperplasia microcalcifications. Post-biopsy changes are present. E. Lymph nodes, right axillary, resection: 11 of i7 additionai lymph nodes contain metastatic lobular carcinoma (11/17). (See template for total lymph node count). A portion of breast tissue is also present which contains a microscopic focus of invasive lobular carcinoma. The margins of resection of that tissue portion are. free of carcinoma. IcD o3 Microscopic Description: CarCinoma,1nF I+rakinq,lobwar,NOS A.,c. and e.: Right Breast - 8Szo|3 Invasive carcinoma: Histologic type: Invasive lobular carcinoma. Sik? breost,nos Histologic grade: 1 Overall grade: c60.4 Architectural score: 3 Nuclear score: 723-iz rD Mitotic score: 1 Greatest dimension (pT): Tumor measures grossly a span of approximately 6 cm (pT3). Specimen margins: Deep margin of the mastectomy is negative for malignancy. Vessel invasion: Negative Nipple: Negative Invasion of skin or chest wall: Negative Description of non-tumorous breast: Fibrocystic changes with ductal hyperplasia and lobular carcinoma in situ.
+
+--- Page 2 ---
+Lymph nodes:  Number of positive nodes of total: 13 of 20 (including 2 of 3 positive sentinel lymph nodes) Size of largest metastasis: 1.1 cm Extracapsular extension (present/absent): Present pN: pN3a. Distant metastasis (pM): pMx Prognostic markers: See prior core biopsy. The invasive tumor was estrogen receptor positive, progesterone receptor positive and showed normal expression for HER-2/neu. B. and D.: Left breast- Invasive carcinoma: Histologic type: Invasive lobular carcinoma Histologic grade: 1 Overall grade: Architectural score: Nuclear score: 1 Mitotic score: Greatest dimension: Residual tumor measures maximally 5 x 5 x 3 mm as measured from the glass slide. Specimen margins: Deep margin mastectomy is negative for malignancy. Vessel invasion: Negative. Nipple: Negative Invasion of skin or chest wall: Negative Description of non-tumorous breast: Fibrocystic changes with ductal hyperplasia and microcalcifications.. Lymph nodes: Number of positive nodes of total: 0 of 1 (sentinel lymph node) pN: pNO Distant metastasis (pM): pMx Prognostic markers: See prior core biopsy (:. The invasive carcinoma was estrogen receptor positive, progesterone receptor positive showed normal expression for HER-2/neu. Specimen A.  Right axillary sentinel node B. Left axillary sentinel node C. Right breast D. Left breast E. Right axillary contents Clinical Information year-old white Bilateral invasive lobular carcinoma Intraoperative Consultation FSA) Right axillary sentinel nodes - Three lymph nodes present. Two of three nodes positive for metastatic lobular carcinoma. FsB) Left axillarv sentinel node - Negative for metastatic carcinoma.
+
+--- Page 3 ---
+Gross Description  Submitted fresh for frozen section labeled "right axillary sentinel node" or 3 nodules of partially cauterized tan yeliow soft tissue. Bisecting the nodules reveal them to range from 0.7-1.8 cm in greatest dimension. They're grossly involved by tumor. Half of each is submitted for frozen section the remainder is kept for permanents. Submitted fresh for frozen section labeled "left axillary sentinel B.  node is enlarged 3 x 2 x 1.5 cm mass of fatty tissue. Bisecting the mass shows it to be possibly a large lymph node replaced with fat. Lymph node is bisected and submitted entirely for frozen section in 2 blo~ke. The remainder of the fat is submitted for permanent sections. c. Received fresh and subsequently fixed in formalin labeled "right breast "is a 22.0 x 20.0 x 5.8 cm mastectomy which is partially covered with a 13.0 x 7.5 cm pink-tan wrinkled skin ellipse having a 2.0 cm everted nipple. The specimen is inked black the deep margin and sectioned to show predominantly fibrous cut surface which is diffusely nodular. Specimen shows an ill circumscribed fibrous mass which is approximately 6 cm in greatest dimension. The shows a 0.8 cm previous biopsy site, partially filled with white rice-like pellets. This comes within 0.5 cm of the deep margin is located toward the lateral aspect of the specimen. The specimen is diffusely nodular firm and rubbery no additional biopsy sites are grossly identified. No lymph nodes are grossly identified in the apex of the specimen. The specimen is collected at . received in pathology at and fixed in formalin at Representative sections of the specimen are submitted as follows: 1 2 - entire nipple with representative skin, 3 - 6 - representative sections of tumor, biopsy site and deep margin, 7 - representative upper outer quadrant, 8 - representative lower outer quadrant,  9 - representative lower inner quadrant, 10 - representative upper inner quadrant. D. Received fresh and subsequently fixed in formalin labeled "left breast "is a 23.0 x 20.0 x 6.5 cm mastectomy which is partially covered with a 13 x 8 cm pink-tan wrinkled skin ellipse having a 2.0 cm everted nipple. The specimen is inked at the deep margin to show a predominantly white yellow nodular fibrous cut surface. There is a 1.5 x 1.2 x 0.5 cm hemorrhagic focus which is grossly consistent with a previous biopsy. Located in the lower outer quadrant, coming within 1.2 identified. The fibrous tissue is remarkably firm and nodular diffusely. No lymph nodes gross identified in the apex of the specimen. The specimen is collected at received in pathology at. and fixed in formalin at.  Representative sections of the specimen are submitted as follows: 1 - 2 - entire nipple with skin, 4 - 6 - entire biopsy site representative deep margin and surrounding tissue, - representative inner upper quadrant,  8 - representative lower inner quadrant, 9 - representative lower outer quadrant, 10 - representative upper outer quadrant. RS 10. E. Received fresh and subsequently fixed in formalin labeled "right axillary content "is a 9.5 x 8.5 x 4.5 cm aggregate of friable fatty tissue. Less than has a suture is undesignated. This may designate the highest node. Due to the fragment in nature, orientation of the remainder of the tissue is indeterminate. Also received is a 6.5 cm additional portion of possible breast tissue was which is fibrous and nodular. Representative sections which include all the lymph nodes are submitted as follows: 1 - representative section of breast tissue, 2 highest node, 3 - 3 possible lymph nodes, - 4 possible lymph nodes, 5. 2 possible lymph nodes, 6 - 5 possible lymph nodes, 7 - 2 possible lymph node. ua
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diff --git a/output/text/75818aa2-09b7-44de-8f83-da77e6ae0eb0.txt b/output/text/75818aa2-09b7-44de-8f83-da77e6ae0eb0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ed316b06d18b8a75412085a53c54bc58d302e9a8
--- /dev/null
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@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+UUID: 38309E84-2CFD-4D1B-8AF4-D8F711679826 Redacted TCGA-LN-A49W-01A-PR Tel: Fax: Clinical Case Report (For Collection of Cancerous Tissue) 1cs-o-3 CucAme, Sfusnoxo cll Nos 8o'70f3 lw 10/s/12 Informed Consent I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator Date Clinical Information. GENERAL INFORMATION Date of Birth (mm/dd/yyyy). Height Marital Status Race Temperature Single Married VIDTNRUESIE Gender Weight  Divorced  Widow Blood Pressure Heart Rate Male  Female 6 to 138 HISTORY OF PRESENT ILLNESS Symptoms:. Fever j wei ghf Loss Clinical Findings: Performance Scale (Karnofsky Score):  100 Asymptomatic  80-90 Symptomatic but Fully Ambulatory  60-70 Symptomatic, in bed less than 50% of day  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden  20-30 Bed Ridden CURRENT MEDICATIONS Drug Dose Route Frequency Date (mm/dd/yyyy) / To / To 1 To / To 1 To
+
+--- Page 2 ---
+PAST MEDICAL HISTORY Diagnosis Date Treatment Status Diagnosis/Disease/Disorder/Injury OB/GYN HISTORY # of Pregnancies Menopausal Status Date of First Menses  Pre-menopausal # of Live Births  Peri-Menopausal Date of Last Menses  Post-menopausal  Oral Contraceptive 0 IuD  Hormone Replacement Birth Control:  Condom Therapy:  Other: SOCIAL HISTORY Environmental Hazards: Occupation: Smoking History TYPE Packs/day Duration When Quit Current Status YES NO I eldcu. (yrs) (yr) Alcohol Consumption TYPE  Drinks/day Duration When Quit Current Status  NO (yrs)[3anm(ls c=c) (yr) $ YES Drug Use TYPE Duration When Quit Current Status Freguency  yeS $NO (yrs) (yr) FAMILY MEDICAL HISTORY Relative Diagnosis Age of Diagnosis. LAB DATA Result Date Test Result Date Test HIV  Positive: CEA   Negative  Positive: Negative CA 15-3  Negative  Positive: Hep B Negative  Positive:  Hep C Negative  Positive: CA 19-9   Negative  Positive: AFP   Negative  Positive: PSA  Negative  Positive: Other: Other:  Negative  Positive:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+DIAGNOSTIC STUDIES Study Results Date Ultrasound X-Ray CT Endoscopy MRI Biopsy  Carci(m? CLINICAL DIAGNOSIS Preoperative Clinical Diagnosis Location of Suspected Involved Lymph Nodes. Location of Suspected Distant Metastasis. Clinical Staging Date of Diagnosis T3 NA MO Stage: 1E Treatment Information SURGICAL TREATMENT Procedure Date of Procedure Resectium dthe Rat sf te oesphagus Wme Primary Tumor Organ Detailed Location Size oeguijys Tmu2 Z x25x/5cm Extension of Tumor ! Lymph Nodes Description Location of Lymph Nodes. # of Lymph Nodes.  Palpable, Non-Dissected Lymph Nodes. Dissected Lymph Nodes Distant Metastasis Organ  Detailed Location Size Surgical Staging T 3 NA Mo. Stage: L NEOADJUVENT THERAPY (Chemo, Radiation, Immuno, Hormonal, or Molecular) Drug/Treatment Dose Route Frequency Date (mm/dd/yyy) / To To 1 To / To / To 1 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Date: Time... Collected by: -- Date: Time:_ Preserved by: SPECIMEN TYPE (# of samples provided)  Blood/Serum/Plasma Slide Frozen  Paraffin Block Diseased Normal  Diseased Normal Diseased Normal Diseased Normal 2 4 2 2 Time to Formalin Time to LN2 Time to LN2 min min /3 min PATHOLOGICAL DESCRIPTION Primary Tumor Size Extension of Tumor Distance to NAT Organ 6 cm Lymph Nodes # Examined # Metastasized Location Distant Metastasis Organ Detailed Location Size Pathological Staging NA m o pT 3. Stage: III Notes: Nock 1M,M2) 4
+
+--- Page 5 ---
+Microscopic Description Histological Pattern Cell Distribution + Structural Pattern + Streaming  Diffuse Mosaic Storiform Necrosis * Fibrosis  Pallsading  Lymphocytic Infiltration Vascular Invasion Cystic Degeneration Clusterized  Bleeding  Alveolar Formation Myxoid Change  Indian File Psammoma/Calcification Cellular Differentiation Adenomatous  Sarcomatous Squamous + + Lymphomatous  Squamoid Cell Glandular cell Round Cell Large Cell Spindle Cell  Cell Stratification Fibroblast Small Cell Secretion Osteoblast Keratin  RS Cell/RS Like Desmosome Intracyt. Vacuole  Lipoblast  Inflam. Cell Pear! Gland formation  Myoblast  Plasma Cell Cellular Differentiation:. E Well  Moderate  Poor Nuclear Appearance Nuclear Atypia: 0 I II III  Aniso Nucleosis Hyperchromatism x Nucleolar Prominent Multinucleated Giant Cell  Mitotic Activity Nuclear Grade: IHC Data  Marker Result  Value Date ER  Negative  Positive PR  Negative   Positive  Her-2/neu  Negative Positive B-Cell Marker  Negative Positive T-Cell Marker  Negative  Positive Other:  Negative   Positive Other: Negative  Positive Final Pathology Report Histological Diagnosis: cell Caacioume) OL lpe Lv(leigee [ Wcell NifterrsDiaies). VGrade:L Comments: 1Ur;Mr (pr8itiue) Pathologist Date 5
+
+--- Page 6 ---
+CONsOLIdateD DiagnOstIc paThoLOgy fORm* Microscopic Appearance: 1. Histological pattern: CELL DISTRIBUTION  Diffuse STRUCTURAL PATTERN X Streaming Mosaic x Storiform Necrosis XFibrosis Lymphocytic Infiltration Vascular Invasion Palisading XCystic Degeneration  Clusterized Bleeding Alveolar Formation Indian File Myxoid Change X Psammoma/Calcification 2. Cellular features: Squamous Adenomatous +  Sarcomatous  Lymphomatous Squamoid Cell Glandular cell Round Cell Spindle Cell Large Cell Cell Stratification Fibroblast Small Cell  Keratin  Secretion Osteoblast  RS CelVRS Like Desmosome Intracyt. Vacuole Lipoblast  Inflam. Cell  Pearl  Gland formation Myoblast  Plasma Cell Otherwise Specified: D,so PrB5% Dz 4O% Dy 5O 2. Cellular Differentiation: Well Moderately Nuclear Atypia: Nuclear Appearance Aniso Nuclcosis Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell X Mitotic Activity Nuclear Grade (qnamys (el tecinmg G ) Histological Diagnosis: Comments: M,- Mr :  carrtnsma mefastosized to L. Date "ATHOLOGIST STAFF FOR RESEARCH USE ONLYJ. *) REPORT OF FINDINGS BY CONTRIBUTOR AND Diagnosis Disc Prirnary Tuinor Site Discrepancy HIPA Discrepancy Prior Maig Dua!/Synctronc aseiscirc
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diff --git a/output/text/75833c1e-7e3c-4ec6-b5f6-a26c63e0b7c3.txt b/output/text/75833c1e-7e3c-4ec6-b5f6-a26c63e0b7c3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ddb504194bcf0db1545062feff44ae036d5a7c2a
--- /dev/null
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+
+--- Page 1 ---
+UUID: 3B7CA8ED-58E2-4609-8E41-4652503732E7 TCGA-E2-A3DX-01A-PR Redacted Surgery Date: SPECIMENS: A. RIGHT BREAST AND AXILLARY CONTENTS B. LEVEL 3 RIGHT AXILLARY LYMPH NODES C. ADDITIONAL RIGHT BREAST TISSUE D. ADDITIONAL RIGHT BREAST TISSUE AND SKIN SPECIMEN(S): A. RIGHT BREAST AND AXILLARY CONTENTS B. LEVEL 3 RIGHT AXILLARY LYMPH NODES C. ADDITiONAL RIGHT BREAST TISSUE D. ADDITIONAL RIGHT BREAST TISSUE AND SKIN DIAGNOSIS: A. BREAST, RIGHT, AND AXILLARY CONTENTS, MODIFIED RADICAL MASTECTOMY:  - THREE FOCI OF INVASIVE LOBULAR CARCINOMA, NOTTINGHAM GRADE 2. - 2.9 Cm, 0.6 Cm anD 0.2 Cm In Size. - FOCALLY PRESENT AT THE ANTERIOR MARGIN AT CENTRAL INFERIOR AND 0.3 CM FROM THE DEEP MARGIN. - EXTENSIVE LOBULAR CARCINOMA iN SITU (LCIS), CLASSIC AND PLEOMORPHIC TYPES, WITH NECROSIS AND MICROCALCIFICATIONS - SKELETAL MUSCLE, NEGATIVE FOR CARCINOMA. - FOCAL GRANULOMAS, FOCALLY NECROTIZING, ARE SEEN IN THE BREAST AND A FEW OF THE LYMPH NODES - METASTATIC CARCINOMA IN 22 OF 33 LYMPH NODES WITH EXTRANODAL EXTENSION, LARGEST METASTASiS iS 1.4 CM (22/33). NOTE: The etiotogy of the granulomas is not entirely clear. Clinical correlation is recommended. B. LYMPH NODES, RIGHT AXILLA, LEVEL 3, DISSECTION: - METASTATIC CARCINOMA IN TWO OF TWO LYMPH NODES (2/2) C. BREAST, RIGHT, ADDITIONAL TISSUE, EXCISION: - METASTATIC CARCINOMA IN ONE OF ONE LYMPH NODE (1/1). D. BREAST, RIGHT, ADDITIONAL TISSUE AND SKIN, EXCISION: - LOBULAR CARCINOMA IN SITU. - BENIGN SKIN. SYNOPTIC REPORT - BREAST Mastectomy 10s-0-3 Specimen Type: Needle Localization:.  No Laterality: Right Cirunuma, infiPtrathy 10bu/xr njrs 8.s~30J3 Invasive Tumor: Present C50.9 .,h1C/24fy Sife : brust, Nos. Multifocality: Yes WHO CLASSIFICATION Invasive lobular carcinoma 8520/3 Tumor size: 2.9cm Tumor Site: 6:00 Margins: Involved at anterior inferior at -- 6:00 Extent:: less than 0.1 cm Tubular Score: 3 Nuclear Grade: 2 Mitotic Score: 1 Modified Scarff Bloom Richardson Grade: 2 Necrosis: Absent Vascular/Lymphatic Invasion:.  None identified Lobular neoplasia: LCIS Lymph nodes: Axillary dissection.
+
+--- Page 2 ---
+Lymph node status:  Positive 25 / 36 Extranodal extension DCIS not present ER/PR/HER2 Results ER: Positive PR: Positive HER2: Positive by FISH Performed on Case: Pathological staging (pTN): :pT2N3 Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition SUMMARY OF IMMUNOHISTOCHEMISTRY/SPECIAL STAINS Material: Block A10 Population: Tumor Cells Stain/Marker:Result:  Comment: CYTOKERATIN AE1/3 Positive At inked margin Material: Block A23 Population: Lymph Node Stain/Marker:Result:  Comment: ACID-FAST BACTERIA STAIN Negative GOMORI METHENAMINE SILVER STAIN Negative The interpretation of the above immunohistochemistry stain or stains is guided by published results in the medical literature, provided package information from the manufacturer and bv internal review of staining performance and assay validation within the The use of one or more reagents in the above tests is regulated as an analyte specific reagent (ASR). These tests were developed and their performance characteristic determined by the I They have not been cleared or approved by the U.S. Food and Drug Administration. The rUA nas determined that such clearance or approval is not necessary. Special stains and/or immunohistochemical stains were performed with appropriately stained positive and negative controls. GROSS DESCRIPTION: A. RIGHT BREAST AND AXILLARY CONTENTSE Received fresh labeled with the patient's identification and designated "right breast and axillary contents" is an oriented (suture in axilla), 445 g, 26 x 21.5 x 2 cm mastectomy with attached axillary tail and a pale-tan skin ellipse,11 x 4.2 cm, and 1 cm in diameter slightly everted nipple. The areolar skin demonstrates a thickened, slightly puckered appearance. Ink coder Posterior-black, anterior/superior- orange, anterior/inferior-blue. The specimen is serially sectioned from medial to lateral into 9 slices (nipple slice 4) revealing 3 separate masses:. Mass #1) 2.9 x 2.5 x 1.8 cm, slices 5-6, central inferior, 6:00, 0.6 cm from the posterior margin and 0.7 cm from the anterior margin Mass #2) 0.7 x 0.5 x 0.5 cm, slice 5, central inferior, extending to anterior margin, 3.5 cm from the posterior margin, and 0.4 cm from Mass #1 Mass #3), 2.5 x 1.5 x 1 cm, slice 7, L0Q, 8:00, 1 cm from anterior margin and 2.1 cm from posterior margin and 4.1 cm from Mass #2
+
+--- Page 3 ---
+The remainder of the specimen shows dense noduiar fibroglandular parenchyma. Multiple possible axillary lymph nodes are identified ranging from 0.2 x 0.2 x 0.2 up to 1.2 x 1 x 0.5 cm. Tissue is. procured, representatively submitted: A1-A2: Nipple A3: Skin, representative sections. A4-A5: Mass #1 with anterior margin, slice 5, 6:00 A6: Deep margin overlying mass #1, slice 5, 6:00 A7: Mass #1, 6:00, slice 5 A8: Tissue in between Mass #1 and Mass #2, slice 5, centrat interior. A9: Mass #2 with anterior margin, slice 5, central inferior A10: Mass #1, slice 6 A11: Slice 6, possible Mass #3. A12-A14: Mass #3, 8:00, LOQ, stice 7, A12 demonstrates anterior margin. A15: Deep margin overlying mass #3, slice 7 A16-A17: Representative sections, UOQ, intramammary fold, slice 8 A18: Representative section, UiQ, slice 3 A19: Representative section, LiQ, stice 3 A20: 4 possible lymph nodes A21: 4 possible lymph nodes A22: 4 possible lymph nodes A23: 2 possible lymph nodes A24: 2 possible lymph nodes A25: 3 possibie lymph nodes A26: 3 possible lymph nodes A27: 2 possibie lymph nodes A28: One lymph node B. LEVEL 3 RIGHT AXILLARY LYMPH NODES Received in formalin labeled with the patient's identification and designated "level 3 right axillary lymph. node" is a 2.5 x 2 x 0.4 cm fibroadipose tissue. One lymph node is identified measuring 1.5 x 1.2 x 0.5 cm. The specimen is entirely submitted: B1: Lymph node B2: Remainder of the specimen. C. ADDITIONAL RIGHT BREAST TISSUE Received in formalin labeled with the patient's identification and designated "additional right breast. tissue" is a fragment of pale tan soft tissue measuring 0.5 x 0.3 x 0.2 cm. Entirely submitted, C1.. D. ADDITIONAL RIGHT BREAST TISSUE AND SKIN Received in formalin labeled with the patient's identification and designated "additional right breast. tissue and skin" is an unoriented, irregular "V" shaped portion of pale tan skin measuring 7 x 2.5 x 0.5 cm. The surface of the specimen appears grossly unremarkable. Serially sectioned, representatively submitted, D1. CLINICAL HISTORY: year-old female, biopsy proven invasive lobular carcinoma, right breast with axillary metastasis. PRE-OPERATIVE DIAGNOSIS: Right breast ca Gross Dictation: , M.D., Patholoaist. ! Final Review... . Final Review: , M.D., Pathologist.. Final: , M.D., Pathologist,
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diff --git a/output/text/7586e688-7681-4ab0-a310-d409e800ab21.txt b/output/text/7586e688-7681-4ab0-a310-d409e800ab21.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9764b47261ccc690e497eaf6871d1ee2e5dcfcc2
--- /dev/null
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@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+RUN DATE: RUN TIME: PAGE 1 RUN USER: PATIENT: ACCT #: LOC: AGE/SX:  ROOM : REG DR: DOB: BED: STATUS: SPEC #: RECD: STATUS: COLL: TIME IN FORMALIN:  UUID:79B9D161-8397-455C-AC36-7DED2D211C95 TCGA-NH-A50T-01A-PR Redacted CLINICAL INFORMATION: Pre-Op Diagnosis: Sigmoid colon neoplasm Remarks: Specimen(s): A. Liver biopsy left lobe B. Splenic flexure colon lesion. C. Left lobe liver biopsy D. Pelvic peritoneal nodule 1cs-0- 3 8140|3 No s Aonrcsrcinome S(tt: colon, spkNic flexure c18.5 MICROSCOPIC DIAGNOSIS lw 11fh2. A LEFT LOBE LIVER (BIOPSY) : GRANULOMATOUS INFLAMMATION NEGATIVE FOR ORGANISMS ON ACID FAST AND FUNGAL STAINS B. COLON AT SPLENIC FLEXURE (LAPAROSCOPIC SEGMENTAL RESECTION) : MODERATELY DIFFERENTIATED ADENOCARCINOMA. INVADING THROUGH THE BOWEL WALL NO METASTASIS IN 10 REGIONAL LYMPH NODES ALL MARGINS UNINVOLVED SEE COMMENT FOR SYNOPTIC REPORTS C. LEFT LOBE LIVER (BIOPSY): GRANULOMATOUS INFLAMMATION NEGATIVE FOR ORGANISMS ON ACID FAST AND FUNGAL STAINS D. PELVIC PERITONEAL NODULE (BIOPSY):S FAT NECROSIS WITH FIBROSIS AND CALCIFICATION COMMENT(S) SURGICAL PATHOLOGY CANCER CASE SUMMARY - CAP APPROVED Specimen: Transverse colon. descending colon. Procedure: Laparoscopic resection Specimen Length: 12 cm Tumor Site: Splenic flexure Tumor Size: 6 cm in greatest dimension Macroscopic Tumor Perforation:. Not identified Histologic Type: Adenocarcinoma Histologic Grade: Low-grade Microscopic Tumor Extension: Tumor invades through the muscularis propria into the ** CONTINUED ON NEXT PAGE **
+
+--- Page 2 ---
+PAGE 2 RUN DATE: RUN TIME: RUN USER: PATIENT: (Continued) SPEC #: Comment(s) (Continued) subserosal adipose tissue. Margins: Distance of invasive carcinoma from closest margin: 2 cm: mucosal margin opposite tattooed margin Proximal: Uninvolved by invasive carcinoma Distal: Uninvolved by invasive carcinoma. Circumferential: Uninvolved by invasive carcinoma Treatment Effect: No prior treatment. Not identified Lymph-Vascular Invasion: Perineural Invasion: Not identified Tumor Deposits: Present Pathologic Staging: Primary Tumor: pT3 Regional Lymph Nodes: pNO. Number examined: 10 Number involved: 0 Distant Metastasis: Not applicable. GROSS DESCRIPTION: Received fresh for frozen section labeled with the patient's name and "liver biopsy" is. a 1 x 0.4 x 0.3 cm linear biopsy of tan tissue totally submitted in block A for frozen section evaluation. B.  Received fresh labeled with the patient's name and "splenic flexure colon lesion" with tissue bank coordinator in attendance is a 12 cm segmental resection of large bowel which requests gross evaluation for margins. Both the measures 4 cm in diameter. surgical margins are stapled and not clinically designated. Tattoo pigment is noted which abuts one staple line. The adipose tissue is wrapped around the serosa in the mid portion.. Blue ink is applied to this area..  The tattoo stapled margin measures 5 cm in length and opposite margin measures 3.5 cm in length. The mesenteric margin measures 3 cm. Blue ink is applied to this margin. In trying to separate the mesentery from the bowel. it is found to be adherent to the bowel surface.". There is some fatty tissue present on the opposite The margins ars removed and the side which may be inclusive of some omental type tissue. lumen probed revealing an obstructing mass present. The tumor measures 6 cm in langth, it involves the entire circumference of the bowel wall. It lies 2.5 cm from the tattooed. margin and 2 cm from the opposite margin. A portion of the edge of the tumor and. non-neoplastic mucosa is provided to the tissue bank coordinator. The spacimen is pinned is out onto a corkboard for several hours of formalin fixation. The partial fixed specimen serially sectioned revealing that the tumor extends deep into the muscle wall. possibly. extending through the muscle wall. A subjacent lymph node is identified measuring 1 cm. The pericolic/mesenteric adipose tissue was placed in a 50/50 solution of lymph node revealing solution and formalin. On cross section, several lymph nodes are identified. which range from 0.4 to 1 cm in greatest dimension each. No omental nodules are identified. Cassette Summary: B1.2 - tattoo pigment B3-8 - representative sections of tumor with blocks 3 and 4 demonstrating adjacent. ** CONTINUED ON NEXT PAGE **
+
+--- Page 3 ---
+RUN DATE: PAGE 3 RUN TIME: Specimen Inquiry RUN USER: SPEC #: PATIENT : (Continued) GROSS DESCRIPTION: (Continued) lymph node B9 omental tissue B11-13- two lymph nodes each bisacted and totally submitted. one inked B14 largest lymph node sectioned and totally submitted C. In formalin labeled with the patient's name and "left lobe liver biopsy" is a 0.7 x 1 x 0.3 cm biopsy of liver tissue. There is a 0.5 x 0.4 cm pale area on the surface. The biopsy is trisected and entirely submitted in block c. In formalin labeled with the patient's name and "pelvic peritoneal nodule" is a 1 x 1 x 0.5 cm triangular shaped portion of gray fatty tissue. There is a 3 mm whitish nodule on the surface.  The specimen is bisected revealing this to be a partially calcified. hemorrhagic nodule possibly representing fat necrosis. The specimen is entirely submitted in block D.. MICROSCOPIC DESCRIPTION: A&C. These biopsies of the left lobe of the liver show focal granulomatous inflammation with fibrosis. The granulomas are mostly noncaseating. composed of epithelioid. histiocytes, multinucleated giant cells and a sprinkling of small lymphocytes. These granulomas are set in a fibrous stroma. A few of the granulomas have scant central. necrosis but most are noncaseating. AFB and GMs stains are obtained on both biopsies. No organisms are seen. D. This is a piece of adipose tissue containing a sclerotic. partially calcified nodule compatible with fat necrosis. There is no evidence of metastatic carcinoma. B.  Sections of the obstructing tumor demonstrate a moderately differentiated. adenocarcinoma which invades through the bowel wall. not quite reaching the subjacent mesenteric lymph node. Discontinuous invasion is noted. No metastasis are identified in 10 regional lymph nodes. INTRAOPERATIVE CONSULTATION: FROZEN SECTION DIAGNOSIS: A. LIVER BIOPSY: NECROTIZING GRANULOMATOUS INFLAMMATION NEGATIVE FOR CARCINOMA RESULTS GIVEN TO IN OPERATING ROOM AT B SPLENIC FLEXURE MASS: GROSS OBSTRUCTING CARCINOMA WITH MARGINS AS FOLLOWS: TATTOO STAPLE LINE 2.5 CM AND OPPOSITE STAPLE LINE 2 CM FINDINGS GIVEN TO IN THE OPERATING ROOM AT ** CONTINUED ON NEXT PAGE **
+
+--- Page 4 ---
+RUN DATE: PAGE 4 RUN TIME: RUN USER: SPEC #: PATIENT : (Continued) PHOTO DOCUMENTATION Image Picture Copy Error Signed (signature on file)_ ** END OF REPORT *
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diff --git a/output/text/75a0a403-fe55-4de6-bdde-4f2a99fb44ee.txt b/output/text/75a0a403-fe55-4de6-bdde-4f2a99fb44ee.txt
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index 0000000000000000000000000000000000000000..376eeeaca9ddeaef9511d6f8eff60b4d5146ee17
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+Page 1 of 3 UUID:A528322F-F869-4016-A8C2-F3A43B39F6AB tcgA-1b-aaun-01a-pr Redacted CONFIDENTIAL SurgiCaL pAthOLOgy rEpOrt Time Collected Time Recelved Time Reported Time Transmitted Order Number Ordering Providerd Status Final Relevant Information Location Copied To Report Patient Name: Demographics (for verification purposes). Sex: F ICD.03 8600/3 SURGICAL PAThOLOgy REPORT 'Areenono, duct Nos! *****Surgical Pathology Report* Accession Number Sute : Fincreow Jeoi LQ5.Q Collected Date/Time Received Date/Time Pathologist Paneras NoS C&s.47 Specimen Description A. Lymph node of group A at AJ s/2oJ14 B. Bile duct margin at c. Whipple's specimen at D. Portal vein margin at Clinical Information Pancreatic mass- head of pancreas Diagnosis A. Lymph nodes, group A, excision: Seven lymph nodes, negative for malignancy (0/7). B. "Bile duct margin", excision: - Benign bile duct with focal acute inflammation and reactive changes. - Negative for malignancy. "Whipple's specimen": Invasive ductal adenocarcinoma, moderately differentiated, 2.3 cm, see synaptic report. - Margins of resection negative (0.1 cm away from the nearest distal pancreatic margin and o.i cm away from the nearest uncinate margin). Extensive perineural invasion. Tumor extends to the vascular bed edge of the specimen,see comment. - Eight peripancreatic lymph nodes, negative for malignancy (0/8). D. Portal vein margin, Excision: - Negative for carcinoma. Reported by: Electronically signed by: Verified: Synoptic Report HISTOLOGIC TYPE: Ductal adenocarcinoma HISTOLOGIC GRADE: G2:  Moderately differentiated MICROSCOPIC TUMOR EXTENSION: Tumor is confined to pancreas MARGINS: Margins uninvolved by invasive carcinoma Distance of invasive carcinoma from closest margin: 1 mm Specified margin:  Uncinate and distal pancreatic margins
+
+--- Page 2 ---
+Page 2 of 3 LYMPH-VASCULAR INVASION: Not identified PERINEURAL INVASION: Present PRIMARY TUMOR (pT) : pT2:  Tumor limited to the pancreas, more than 2 cm in greatest dimension. REGIONAL LYMPH NODES (pN) : pNO:  No regional lymph node metastasis Number examined: 15 Number involved: 0 Gross Description Received are specimen containers A to n 1  -oquisitions and specimen containers are labelled with the patient's name,. The cassettes and identifiers are labelled with the Surgical Number. A. Specimen is received in formalin.. The container is designated "A: Lymph node of group A". The specimen consists of a fibrofatty soft tissue measuring 2.2 x 1.7 x 0.7 cm. In consists of four potential lymph node candidates, measuring 0.5 to 1.1 cm in maximum diameter. Specimen is submitted as follows: A1. four lymph node candidates A2. three lymph node candidates B. The specimen consists of irregularly shaped fragment; 1.2 x 0.5 x 0.3 cm. There is an edge that possibly represents the bile duct wall, but no circular structure is present. Submitted in toto in one cassette. Specimen is received fresh. The container is designated "B: Bile duct margin". The  specimen contains an irregularly shaped fragment of soft tissue, measuring 1.2 x 0.5 x 0.3 cm. There is an edge that represents a possible epithelial duct wall, but no circular structures present. The specimen is entirely submitted for frozen section diagnosis.. C. Specimen is received fresh. The container is designated "c: Whipple's specimen". It. consists of a Whipple resection specimen including duodenum, head of the pancreas, and common bile duct stump. The proximal margin of the specimen measures 6.0 cm in circumference. The inferior margin measures 5.0 cm (circumference). The duodenum is 25.0 cm in length, 4.5 cm in average circumference and 0.4 cm in wall thickness. The pancreas measures 3.8 x 3.5 x 2.5 cm. The common bile duct stump is 6.1 cm in length and i.2 cm in diameter at the margin. The specimen is inked as follows: pancreatic body margin. (distal)- blue, uncinate process- orange, vessel bed area- black. When opened, the duodenal mucosa is velvety and grossly unremarkable. The ampulla of vater is identified and is open to show a 1.2 cm diameter ampulla. Serial sectioning of the pancreas reveals a mass measuring 2.3 x 2.1 x 1.8 cm with non-homogenous white-tan cut surface. The mass is located approximately 1.2 cm away from the duodenal wall and grossly abutting blue and orange resection margins.  The uninvolved pancreas is pink/tan. Multiple lymph nodes are. identified in the soft tissue around the pancreas, measuring 0.3 to 1.1 cm in greater dimension. One node shows hemorrhagic changes. Representative sections of the specimen are submitted as follows: C1. proximal bile duct margin, cross section C2 to 4. distal pancreatic margin, posterior to anterior C5. representative proximal gastric/ duodenal margin. c6. representative distal duodenal margin. c7/8.  mass with uncinate margin c9. representative section of common bile duct, cross section C10 to 16. mass with the closest common bile duct (c1o-1l contiguous sections). C17. uninvolved pancreas C18. hemorrhagic nodule C19/20. six lymph node candidates (three lymph nodes each). C21. two lymph node candidates D. Specimen is received in formalin. The container is designated "p: Portal vein margin". It consists of an unorientated fragment of soft tissue measuring 1.5 x 1.0 x 0.3 cm. The specimen is bisected and submitted entirely in cassette D1.. Frozen Section Diagnosis B. Bile Duct Margin: Negative for malignancy. Reported by: Frozen Section Microscopic. B. Prominent inflammation; loss of surface epithelium; and reactive changes in periductal glands. Pathologist Comment The tumor extends into the black inked edge of the specimen designated as vascular bed. However, a separate portal vein margin is separately submitted (specimen D) which is. negative for malignancy.
+
+--- Page 3 ---
+Page 3 of 3 Accesslon Number Encounter Number Patlent Location 1414 ZZ527
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index 0000000000000000000000000000000000000000..32ab13da64a3f9a2e0399ee83f53d3d988edb4eb
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+
+--- Page 1 ---
+UUID:F124155D-6131-47F6-8320-46A41AB125D33 CGA-AN-A0FD-01A-PR Redacted TSS Patient ID: Case #: : DOB: Sex: Female Ethnicity (Race): Cancer Sample Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma Date of Procurement. Anatomic Site: Right breast Tumor location: Primary. Tissue Specification: Tumor Specimen Matrix: Tissue Specimen Format: OCT Container: block Type of Procurement: surgery Grade: 2. T Stage:2 N Stage: 0 M Stage: 0 Treatment: none. Treatment Details: n/a  Normal Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw Matrix: Blood Specimen Format: frozen Container: tube Date of Procurement:. 1cs-0-3 carcioma, nifiHtrahiry duct, Nos 85v0/3 Site: breast, Nos. C50.9 lu 10f21/ Jefa+/+
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diff --git a/output/text/75a4d2da-6b7d-426c-93c5-7791eb730699.txt b/output/text/75a4d2da-6b7d-426c-93c5-7791eb730699.txt
new file mode 100644
index 0000000000000000000000000000000000000000..13dfe41c8faf134548258659d9cb96b824d94ea3
--- /dev/null
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+
+--- Page 1 ---
+Received: Status: Specimen: Spec Type: SURGICAL P Subm Dr: . 1cs-0-3 BREAST CANCER Cs0.9 h 1|31/n Site: brust, No5 DATE: DOCTOR(S) : UUID: 781E6EEB-3B61-4CE8-B695-ED11C2EF169F Reda cted A.  LEFT BREAST SUPERFICIAL MARGIN RE-EXCISION TCGA-A2-A0T5-01A-PR RIGHT BREAST C. LEFT BREAST PART A RECEIVED LABELED LEFT BREAST UPPER OUTER QUADRANT SUPERFICIAL MARGIN REEXCISION STITCH NEW MARGIN, IS AN IRREGULAR PORTIONS OF YELLOW-PINK FATTY TISSUE MEASURING 12.5 X 7.5 X 1.0 CM IN GREATEST DIMENSIONS. A SUTURE DENOTES THE NEW MARGIN. THIS SIDE IS MARKED WITH BLUE INK WITH A PERIMETER OF BLACK INK.  REPRESENTATIVE SECTIONS TO INCLUDE APPROXIMATELY 4O% OF THE SPECIMEN ARE SUBMITTED LABELED A1 THROUGH 10. RIGHT BREAST STITCH AT 12 PART B RECEIVED LABELED O'CLOCK, IS A SIMPLE MASTECTOMY SPECIMEN MEASURING 24 X 18.5 X 5.5 CM. THE NIPPLE IS GROSSLY UNREMARKABLE WITHIN A 7 X 3.5-CM SKIN ELLIPSE. A SUTURE DENOTES 12 O'CLOCK.  THE SUPERFICIAL ASPECT IS MARKED WITH BLUE INK, THE DEEP WITH BLACK.  SECTIONING REVEALS DENSE GRAY-TAN FIBROUS TISSUE INTERMIXED WITH YELLOW FATTY TISSUE. THE FIBROUS TISSUE IS THIS IS SURROUNDED PRIMARILY IN THE MID TO LOWER OUTER QUADRANT AREAS. BY BLAND YELLOW FATTY TISSUE. THE FIBROUS TISSUE COMPRISES UP TO 4Ot OF THE SPECIMEN. SECTIONS ARE SUBMITTED AS FOLLOWS: B1--NIPPLE, B2--CENTRAL DEEP MARGIN, B3 AND 4--UPPER INNER QUADRANT, B5 AND 6--UPPER OUTER QUADRANT, B7 AND 8--LOWER OUTER QUADRANT, B9 AND 10--LOWER INNER QUADRANT. LEFT BREAST STITCH AT 12 PART C RECEIVED FRESH LABELED O'CLOCK, IS A 26 X 18 X 6-CM SIMPLE MASTECTOMY SPECIMEN. THE NIPPLE IS UNREMARKABLE WITHIN AN 8 X 4.2-CM SKIN ELLIPSE. A SUTURE DENOTES 12 O'CLOCK.  THE SUPERFICIAL ASPECT IS MARKED WITH BLUE INK,,THE DEEP WITH BLACK.  SECTIONING REVEALS A PINK-TAN FIRM GRITTY MASS AT' O'CLOCK LATERAL BREAST. THIS AREA MEASURES 4.5 X 2.4 X 4.0 CM IN GREATEST DIMENSIONS.  THE TISSUE BETWEEN THIS LESION AND THE DEEP MARGIN CONSISTS OF YELLOW FATTY TISSUE AND PINK-TAN FIBROUS TISSUE. THE MARGIN GROSSLY THERE IS A IS O.8 CM AWAY.  THIS IS O.8 CM FROM THE PROXIMAL MARGIN. SECOND PALPABLE AREA OF FIRMNESS IN THE UPPER OUTER QUADRANT AT THE LATERAL EDGE OF THE SPECIMEN WHICH WHEN SECTIONED REVEALS NO GROSS BY PALPATION, THIS AREA IS 2 CM IN GREATEST DIMENSION. THIS LESION. AREA DOES DEMONSTRATE YELLOW-WHITE COLORATION SUGGESTIVE OF GROSS FAT
+
+--- Page 2 ---
+Specimen Received: Status: Spec Type: : SURGICAL P Subm Dr: !!i'! (Continued) NECROSIS.  THIS AREA IS 5 CM FROM THE LESION.  CENTRALLY, THE BREAST DOES DEMONSTRATE GRAY-TAN FIBROUS TISSUE. THE PERIMETER OF THE SPECIMEN IS BLAND YELLOW FATTY TISSUE. THE FIBROUS TISSUE COMPRISES NO MORE THAN 25% OF THE SPECIMEN. SECTIONS ARE SUBMITTED AS FOLLOWS: C1--NIPPLE AND SKIN (MIRROR IMAGE TO PROTOCOL). C2 AND 3--FULL CROSS-SECTION OF LESION (MIRROR IMAGE TO TISSUE TAKEN PER PROTOCOL). C4--LESION AND DEEP MARGIN, C5 AND 6--LESION AND SUPERFICIAL MARGIN, C7 AND 8--FULL CROSS-SECTION OF LESION (MIRROR IMAGE TO TISSUE TAKEN PER PROTOCOL), C9 AND 1O--TISSUE EXTREME UPPER OUTER QUADRANT WITH INDURATION, C11--CENTRAL BREAST TISSUE WITH FIBROSIS, C12--UPPER OUTER QUADRANT, C13--UPPER INNER QUADRANT, C14--LOWER INNER QUADRANT, C15--LOWER OUTER QUADRANT. PROCEDURES : 88307/3, A BLK/10, B BLK/10, C BLK/15 PART A LEFT BREAST UPPER OUTER QUADRANT SUPERFICIAL MARGIN REEXCISION: FIBROADIPOSE TISSUE WITH NO EVIDENCE OF NEOPLASM.  THE NEW INKED MARGIN IS FREE OF NEOPLASM. FOCUS OF PREVIOUS BIOPSY SITE CHANGE WITH ORGANIZING FAT NECROSIS WITH REACTIVE FIBROSIS. PART B RIGHT BREAST, SIMPLE MASTECTOMY: FIBROCYSTIC DISEASE WITH PATCHY FIBROSIS, APOCRINE METAPLASIA, CYST FORMATION AND A SMALL FIBROADENOMA. NO EVIDENCE OF ATYPIA OR MALIGNANCY. UNREMARKABLE NIPPLE SKIN. A M *cystFA PART C : LEFT BREAST, SIMPLE MASTECTOMY: DcIs 10% 1. MODERATELY DIFFERENTIATED INTRADUCTAL AND INFILTRATING DUCT CARCINOMA, NUCLEAR GRADE II WITH LOW MITOTIC INDEX, WITH AN IN SITU Sold/cngntrp COMPONENT OF APPROXIMATELY 1O% OF SOLID AND CRIBRIFORM TYPE WITH FOCI iDc zJz1 OF INTRADUCTAL NECROSIS. 4.Scm  THE TUMOR GROSSLY MEASURES 4.5 CM IN GREATEST DIMENSION. THE NIPPLE, 2. S Kin|nippk DEEP AND SUPERFICIAL MARGINS ARE FREE OF NEOPLASM. +LvI 3. FOCI SUSPICIOUS FOR LYMPHATIC INVASION ARE PRESENT. BIOPSY SITE CHANGE WITH REACTIVE FIBROSIS AND ORGANIZING FAT NECROSIS INCLUDING AN AREA FROM THE UPPER OUTER QUADRANT WHICH MAY REPRESENT A PREVIOUS SENTINEL NODE BIOPSY SITE.S 5. FIBROCYSTIC CHANGE WITH PATCHY DENSE FIBROSIS AND CYST FORMATION.
+
+--- Page 3 ---
+Patrantl Specimen: Received: Status: Spec Type:  SURGICAL P Subm Dr: 1 Signed (prelim.) (signature on file)
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diff --git a/output/text/75ab949c-f473-4a9f-a04d-06c275b68c49.txt b/output/text/75ab949c-f473-4a9f-a04d-06c275b68c49.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4a33ff173e7816c6f30661970cacb62a7fe2d37b
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+TCGA-A6-3809 SPECIMEN Extended right hemicolectiomy - subtotal colectomy CLINICAL NOTES PRE-op DIAGnosI: Carcinoma transverse colon GROSS DESCRIPTION Received fresh in a container labeled "extended right hemicolectomy - subtotal colectomy" is a segment of bowel consisting of 6 cm. of terminal ileum with 50 cm of contiguous colon. There is a 30 x 11 x 1 cm. portion of omentum which is adherent to the outer aspect of the colon wall over an area 6 x 5 cm, with induration of the omentum in that area. The serosal surface of the bowel away from where the omentum is attached is glistening and tan-pink. No appendix is present with the specimen. The bowel is opened. The small bowel averages 4.5 cm. in circumference and the colon averages 8.5 cm. in circumference. The mucosa of the small bowel is tan-pink, smooth, and glistening, with a normal pattern of folds. There are no focal lesions in the small bowel. The colon is notable for a circumferential mass, with the bowel 12 cm. in circumference in this region, with this mass 9 cm. long and maximally 1.2 cm. thick. Sectioning through the mass reveals the tumor to invade through the bowel wall into fat in the region with adherent omentum noted above, appearing to involve the omentum. The tumor comes very near to, but does not clearly reach, the outer margin. The tumor is 24 cm. from the distal resection margin. The remainder of the colonic mucosa is tan-pink with edematous folds, with additional polyps up to 0.3 cm. in greatest dimension. Thee adipose tissue is dissected, and there are multiple soft tan lymph nodes identified. Rs-12, following fixation. BLOck suMMARy: 1 - proximal and distal resection margins; 2 -- ileocecal valve; 3 - mucosa away from mass, including polyps; 4-7 - tumor, including relationship to omentum; 8-12 - lymph nodes. GROSS DESCRIPTION
+
+--- Page 2 ---
+MICROSCOPIC DESCRIPTION The following template summarizes the findings in this case: Histologic type: Adenocarcinoma, with some features of mucinous adenocarcinoma. Histologic grade: Moderately differentiated Primary tumor (pT): Adenocarcinoma invades through the full thickness of the bowel wall into the surrounding adipose tissue. grossly this appeared to be into omentum, it is favored this is. pT4. Proximal margin: Negative Distal margin: Negative Circumferential (radial) margin: Tumor is not at the outer surface of the specimen, but is <l mm from the outer surface where the. omentum is adherent. Clinical correlation is recommended regarding whether this is radial margin or a free surface. Distance of tumor from closest margin: See above Vascular invasion: Not definitively identified Regional lymph nodes (pN): pN0. Twenty-four lymph nodes are identified and they are negative for malignancy. Non-lymph node pericolonic tumor: I  Not identified Distant metastasis (pM): pMX Other findings: There is prominent necrosis in areas of the tumor. There is a separate adenomatous polyp. Note: This case has been discussed with DIAGNOSIS Terminal ileum and extended right hemicolectomy-subtotal colectomy, excision - Moderately differentiated adenocarcinoma, with some features of mucinous adenocarcinoma, invading throught the full thickness of. colonic wall and into surrounding adipose tissue and adherent omentum (see microscopic description). Proximal and distal resection margins negative for malignancy, with tumor <1 mm from outer surface of specimen (see microscopic description). Twenty-four lymph nodes negative for malignancy. End Of Report
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diff --git a/output/text/760d5a7a-5919-41ee-bad1-b594836d4bec.txt b/output/text/760d5a7a-5919-41ee-bad1-b594836d4bec.txt
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index 0000000000000000000000000000000000000000..3381cbb9e692e043a0fb9fcb7bb08ab36612f39a
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+
+--- Page 1 ---
+UUID:C13D16C9-BAC7-4CA4-B062-D925466F9E28 TCGA-LQ-A4E4-01A-PR Redacted Patient: Pathology #: Med. Record. No.: Age: Date of Procedure Date of Birth: Sex F Date.Received: Submitted by: Report also to. Pathology Report DIAGNOSIS: A. Right axillary sentinel node: Lymph node with metastatic.mammary carcinoma (5 mm focus), with extranodal extension (less than 2 mmm). B. Right axillary sentinel nodes: Metastatic:mammary carcinoma (5 mm focus), without extracapsular extension involving. 1 of 2 lymph nodes. C. Left breast tissue: Benign breast tissue with fibrocystic changes.. 1co-0-3 Cmcinoma, hifil+nstng 1obule, N05 8500/3 D. S.tu : brast, Nos c50.9 SPECIMEN Laterality: Right breast. 9/27/12 Specimen(s): Modified radical mastectomy TUMOR Histologic type: Invasive lobular carcinoma (two separate lesions) Histologic grade: Grade 1 Tumor grade (Nottingham combined) based on the following: Tubule formation score: 3 Nuclear pleomorphism score: Mitotic count score: 1 Total score (range of 3-9): 5 Tumor size (greatest dimension):  7cm Tumor site (quadrant):.  Upper outer Tumor site (add'l descriptors): O'clock orientation: Larger lesion - upper outer (9:00 - 11:00) 5-6 cm from nipple; and smaller lesion - upper inner (2:00) 7-8 cm from nipple Peritumoral intralymphatic tumor emboli:. Absent Dermal lymphatic involvement:  Absent Status of skin/nipple: Not involved Coexistent DCIS: Absent Pathology Report Page 1 of 4
+
+--- Page 2 ---
+Patient: Microcalcifications: Absent Additional findings: None MARGINS Regarding invasive carcinoma: Margin(s) positive: Posterior margin - 2mm linear extent Margin(s) negative: Superior:  >1 cm Medial: >1 cm Inferior: >1 cm Lateral: >1 cm ANCILLARY STUDIES IHC for ER and PR: Performed on a prior sample See report: HER2 amplification by FiSH:  Performed on a prior samole See report: REGIONAL LYMPH NODES Positive for metastatic carcinoma (at least one focus > 0.2mm in size). Number of nodes positive: Total number of nodes evaluated: 26 Size of largest metastatic focus: 5mm Extranodal extension: Present (tumor extends 2 mm or less beyond node capsule). Comment: The two positive lymph nodes are the sentinel lymph nodes from Part A (one sentinel node) and Part B (1 of 2 sentinel nodes).. STAGING (AJCC) Primary Tumor: pT3 Lymph Nodes: pN1a Distant Metastasis: Not applicable CLINICAL INFORMATION: Right breast multicentric cancer, ER/PR done previous biopsy. SPECIMEN(S) RECEIVED: A. Right axillary sentinel node B. Right axiliary sentinel nodes C. Left breast tissue D. Right modified radial mastectomy with multicentric cancer. GROSS DESCRIPTION: A. Received fresh is a 2.3 x 2 x 1.5 cm fragment of golden yellow fibroadipose tissue containing one rubbery. partially fat-replaced 1.1 x 1 x 0.4 cm lymph node. The node is bisected and submitted far frozen section in A1 FROzEN SECtiON DiAGNOSIS: Lymph node, positive for metastatic breast carcinoma: Pathology Report Page 2 of 4
+
+--- Page 3 ---
+Patient: B. Received fresh is a 3 x 2 x 1.5 cm fragment ot golden yellow fibroadipose tissue. Dissection reveals two rubbery. partially fat-replaced nodes, 0.6 x 0.6 x 0.4 cm and 1.1 x 0.9 x 0.5 cm. Both nodes are bisected and submitted for permanent section in 81 and B2. C. Received fresh are two fragments of tobular golden yellow fibroadipose tissue along with attached and  unattached smooth, unremarkable tan-red skin weighing 256 grams in aggregate and measuring from 5 x 3.4 x 2.2 cm to 16 x 11 x 3.5 cm. Sectioning reveals a cut surface consistent of lobular yellow adipose tissue interspersed with fibrous pink-white breast parenchyma. Representative tissue is submitted in C1 - C2. D. Fixed in formalin for approximately 33 hours is a 1,215 gram modified radical mastectomy with the breast proper measuring 20 cm from medial to lateral x 19.5 cm from superior to inferior x 7 cm from anterior to posterior. Dissection of the 11 x 6 x 4 cm axillary tail reveals several rubbery tan-red lymph nodes, 0.3 to 2.3 x 1.5 x 1.1 cm. There is an 18 x 9 cm ellipse of tan-red skin on the anterior surface with a superomedial placed nipple. The superior margin is inked black, inferior blue. medial green, lateral yellow and posterior red. The specimen is serially sectioned from medial to lateral into 17 slices measuring from 1 to 1.3 cm. In the upper outer quadrant of the breast is a large firm, multinodular, ill-detined 7 x 5 x 3.8 cm pink-gray mass which extends from the 9 to 11 o'clock position, 5-6 cm away from the nipple. This large, multinodular lesion appears grossly to come within 0.5 cm of the posterior margin, 1.5 cm of the superior margin and greater than 2 cm away from all remaining margins. In the upper inner quadrant of the breast at approximately the 2 o'clock position, 7-8 cm away from the nipple is a smalier, firm, ill-defined 0.9 x 0.9 x 0.8 cm pink-gray mass located 1 cm away from the superior margin and greater than 2 cm from all remaining margins. This mass appears grossly to be located 3.5 cm away from the larger lesion The rest of the specimen consists af lobular yellow adipose tissue interspersed with fibrous pink-white breast parenchyma. A photograph of slices 4 through 14 is taken to illustrate both lesions and their relationship to the inked margins. Sections submitted are indicated on the photograph and are sublabeled D10-D25. Sections to include the mass at 2 o'clock are in D10 and D11, and the mass at the 1 to 3 o'clack position is in D14. D15, 017. D20, D21. D22. D23. D24 and D25. The nipple is in D13, and an additional section of mediai breast is in D8 and lateral breast in D9. The lymph nodes are submitted as follaws: D1-D2 -- one node trisected: D3 -- one node bisected; D4-D7 -- intact lymph nodes; D8 -- medial breast tissue; D9 -- Iateral breast tissue. Slides were microscopically examined by the pathalogist Immunohistochemistry Results Formalin-fixed. paraffin-embedded tissue is utilized. Tissue sections are incubated with the following antibodies. Positive and negative controls stain appropriately. Camplete procedural methodology is available upon request. Results indicated below. Material: Block D22 Marker For: Result Comment e-Cadnerin Negative The immunohistochemical findings support the diagnosis of invasive lobular carcinoma. stigs of atl immunonistochemical stains cted in ths report were determined by the Department ot Pathoiogy at as part of an ongoing quaty assurance program and in compliance with federally mandated regulations drawn rrom ine Cunical Laboratory #provement Amendments of 1988 (CLiA '88) Some of these fests may rely on the use of *anaiyte specific reagents' and have not been cleared or approved by the U.S Food and Drug Adminrstration The FDA nas determined that such clearance or  approval is not necessary. Nevertheless. federal rules concerning the medical use of analyte specific reagents require that the fotowng disciaimer be attached to this report. These tests are used for rinral nurnneae and should not be regarded as investigational or for research The immunonistochemistry lataratory at Jepartment ot Pathoicgy is certified by the Centers for Medicare  and Medicaid Services (formerly HCFA) as a hgh complexity laboratory uncer CLiA 88 Pathology Report Page 3 of 4
+
+--- Page 4 ---
+Patient: MRN: vauation.a..r Pathology Reporte Page 4 of 4
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diff --git a/output/text/7612cd43-e078-4d66-bda5-471ba644d4ab.txt b/output/text/7612cd43-e078-4d66-bda5-471ba644d4ab.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2ba6657c79727daf657d0676cc34a63fedeb16a7
--- /dev/null
+++ b/output/text/7612cd43-e078-4d66-bda5-471ba644d4ab.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+UUID:0698B674-4D6D-4FEF-8129-F66DF28A45F9 Redacted SUrGICAl PATHOLOgy REPORT Patient Name. Accession #: Med. Rec.#: Visit #: Service Date: DOB: Sex: Male Received: Soc. Sec. #: Location: Client: Physician(s): IcDD- FInal Pathologic Diagnosis 8/20/3 Hladder arterier cel A. Left ureter, biopsy: No dysplasia or carcinoma.. Dete C673 B. Right ureter, biopsy: No dysplasia or carcinoma.. C. Urinary bladder and prostate, cystoprostatectomy:. - Urinary bladder:. 1. High-grade urothelial carcinoma invasive into perivesicular adipose tissue, margins negative; see comment. 2. No tumor in two lymph nodes (0/2). - Prostate: Nodular stromal hyperplasia and glandular atrophy with focal squamous metaplasia, no carcinoma. D. Lymph nodes, right obturator, dissection: No tumor in three lymph nodes (0/3) E. Lymph nodes, right internal iliac, dissection: No tumor in seven lymph nodes (0/7). F. Lymph nodes, right external iliac, dissection: No tumor in two lymph nodes (0/2) G. Lymph nodes, left pelvic, dissection: No tumor in eleven lymph nodes (0/11) H. Left ureter, resection: No dysplasia or carcinoma.. I. Right ureter, resection: No dysplasia or carcinoma.. Comment: Bladder Tumor Synoptic Comment Page 1 of 4
+
+--- Page 2 ---
+- Tumor type: Urothellal carcinoma. - Tumor grade: High grade. - Tumor size: 3.2 x 2.5 x 1.8 cm. - Extent of tumor in bladder: Invasive through muscularis propria into perivesicular tissue (slide C6). - Lymphatic/vascular invasion: Present. Slide C4. An immunohistochemical stain for CD34 was obtained and confirms the presence of tumor within small vascular spaces. - Epithelial abnormalities in bladder: None. - Extension of tumor into adjacent organs: None. - Margins: - Urethral margin: Negative (invasive tumor is 4.8 cm from margin).. - Right ureter margin: Negative. - Left ureter margin: Negative. - Perlvesical margin: Negative (tumor is 0.7 cm from margin) - Lymph node status: Negative. - total number of nodes examined: 25. - Other pathologic findlngs in bladder: Foreign body giant cell reaction consistent with prior transurethral resection of bladder tumor. - AJCc/UIcC stage: pT3aN0. While focal urothelial cell atypia is present on multiple frozen sections, the final permanent sections fail to show definitive urothelial dysplasia or carcinoma in situ in these sections. Dr..  has reviewed the frozen sections and corresponding permanent slides. Specimen(s) Received A:Left ureter (FS) B:Right ureter (FS) C:Bladder and prostate (FS on urethra) D:Lymph node, right obturator E:Lymph node, right internal iliac F:Lymph node, right external iliac G:Lymph node, left pelvic H:Left ureter I:Right ureter Intraoperative Diagnosis FS1 (A) Left ureter, biopsy: Focal urothelial atypia. No invasive carcinoma. Dr.. Concurs. FS2 (B) Right ureter, biopsy: No high-grade dysplasia or invasive carcinoma. Dr.. concurs. FS3 (C) Urethral margin, biopsy: Focal urothelial atypia, no invasive carcinoma. (Dr.. Clinical History The patient is an -year-old man with a history of high-grade urothelial carcinoma  involving the left lateral wall. He now undergoes a radical cystoprostatectomy with bilateral lymph node dissection. Gross Description The specimen is received in nine parts, each labeled with the patient's name and unit number. Parts A-C are recelved fresh. Parts D-I are received in formalin. Part A, additionally labeled *left ureter," consists of one, soft, pink, ovoid, irregular unoriented tissue fragment (0.8 x 0.8 x 0.3 cm). The entire specimen is frozen for frozen section diagnosis 1, and Page 2 of 4
+
+--- Page 3 ---
+subsequently submitted in cassette A1.. Part B, additionally labeled "right ureter," consists of one, soft, pink, irregular, unoriented tissue fragment (1.7 x 0.4 x 0.3 cm). The entire intact specimen is frozen for frozen section diagnosis 2, and subsequently submitted in cassette B1. Part C, additionaily labeled "bladder and prostate," consists of a cystoprostatectomy specimen containing bladder (312 gm; 10 cm from right to left x 4 cm from anterior to posterior x 22.2 cm from superior to inferior, with attached ureters) and prostate (4.5 cm from apex to base x 5.2 cm in width x 4.8 cm from anterior to posterior). GROss PATHOLOgIC FINDINGS: There is one soft, tan-pink to red, friable, fungating mass (3.2 x 2.5 x 1.8 cm) located along the left anterior wall, abutting the left ureteral orifice. The mass grossly appears to extend into the deep muscularis propria and is located O.5 cm from the anterior surgical margin, 1.3 cm from the posterior margin and 4.8 cm from the urethral margin. The remainder of the biadder mucosa is edematous and pink-red. Within the prostate there are multiple tan, rubbery nodules (largest 0.5 cm in greatest dimension) located centrally and one yellow-tan 0.4 cm cyst in the right mid-gland. the remaining prostate parenchyma is tan-pink. The ureters (left ureter 8.2 cm in length x 0.3 cm in diameter, right ureter 7.3 cm in length x 0.2 cm in diameter) are soft tan-brown without masses or lesions. One fleshy, tan lymph node is identified in the perivesicular soft tissue measuring 0.4 cm in greatest dimension. The seminal vesicle/vas deferens bundles are soft, lobulated, red-tan without obvious lesion or mass. ORIENTED BY: Anatomic landmarks, trigone. INTRAOPERATIVE EVALUATION: Frozen section of urethral margin, en face, is submitted for frozen section diagnosis 3. INKING: - Anterior right surface: Green. - Anterior left surface: Blue. - Posterior surface: Black. GROSS PHOTOGRAPHS: Yes. CAssETTEs: Representative sections are subrmitted as follows: C1: Urethral margin, frozen remnant.. C2: Left ureter margin, en face. C3: Right ureter margin, en face. C4: Mass at left anterior wall, margin.. C5: Mass at closest approach to prostate. C6: Mass at left ureteral orifice, trigone. c7: Left posterior wall, adjacent to mass. c8: Right bladder wall. c9: Bladder dome wall. C10: Prostate, left apical margin, perpendicular. C11: Prostate, right apical margin, perpendicular.. C12: Prostate, left apex. C13: Prostate, left mid gland. C14: Prostate, left base. C15: Prostate, right apex. C16: Prostate, right mid gland.. C17: Prostate, right base. C18: Candidate lymph nodes, whole. C19: Posterior biadder wall. C20-C24: Candidate lymph nodes, whole. C25: Distal Prostatic urethra. Part D, labeled "right obturator nodes," consists of a single, soft, roughly ovoid piece of tan and pale yellow fatty tissue (4.2 x 2 x 1.2 cm). Two candidate lymph nodes are found (0.1 cm and 3 cm in  Page 3 of 4
+
+--- Page 4 ---
+greatest dimension). The candidate lymph nodes are submitted in cassette D1. The remaining fatty. tissue is returned to the container. Part E, labeled *right internal iliac nodes," consists of two, soft irregular pieces of brown and pale yellow fatty tissue (5.2 x 3.6 x 1.5 cm in aggregate). Seven candidate lymph nodes are found (0.5 cm to 1.1 cm in greatest dimension). The candidate lymph nodes are submitted in cassette E1. The remaining fatty tissue is returned to the container. Part F, iabeled "right external iliac nodes," consists of two, soft, irregular pieces of brown and yellow fatty tissue (3.2 x 1.7 x 0.9 cm in aggregate). Two candidate lymph nodes are found (0.7 cm and 0.8 cm in greatest dimension). The candidate lymph nodes are submitted in cassette F1. The remaining fatty tissue is returned to the container. Part G, labeled "left pelvic lymph nodes," consists of multipie, soft, irregular pieces of brown and yellow fatty tissue (5.5 x 3.5 x 1.7 cm in aggregate). Nine candidate lymph nodes are found (0.5 cm to 1.4 cm in greatest dimension). The candidate lymph nodes are submitted as follows:. Cassette G1: Seven nodes. Cassette G2: Two nodes. The remaining fatty tissue is returned to the container. Part H, labeled "teft ureter," consists of a single, firm, tubular piece of off-white tissue with attached brown fibrofatty tissue (1 cm length x 0.8 cm average diameter). The lumen is patent (0.2 cm. diarneter). One end has a metal clip; this end is inked blue, and the opposite end is inked black. The specimen is serially sectioned and no lesions are seen. The entire specimen is submitted as follows: Cassette H1: Ends. Cassette H2: Central sections. Part I, labeled "final right ureter," consists of a single, firm, tubular piece of off-white tissue (2.8 cm Iength x 0.5 cm average diameter) with attached tan-yellow fibrofatty tissue. The lumen is pinpoint. One end has a metal clip; this end is inked blue, and the opposite end is inked black. The specimen is serially sectioned and no lesions are seen. The entire specimen is submitted as follows:. Cassette I1: Ends. Cassettes I2-13: Central sections. The immunoperoxidase stain(s) reported above were developed and their performance characterlstics determined by the They have not been cleared or approved by the U. S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of i988 ("CLIA") as qualified to perform high-complexity clinical testing.. Diagnosis based on gross and microscopic examinations. Final diagnosis made by attending pathologist following review of all pathology slides. Pathology Resident Pathologist Electronicaliy signed out on UXY2013 Page 4 of 4
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new file mode 100644
index 0000000000000000000000000000000000000000..0f810e374b8bf68f9138083073829e90a893616e
--- /dev/null
+++ b/output/text/7614ea99-e850-42c6-a835-7ce4b2f8c7d0.txt
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+
+--- Page 1 ---
+UUID:4D0D9EE2-7FEF-4E5F-922C-EE98200C4C61 TCGA-DM-A0XD-01A-PR Redacted TSS Patient ID: Sample Procurement: Date:e Date of Birth: Gender: Vital Status: Deceased Date of Death: Race: White Ethnicity: Not Hispanic or Latino  Specific Ethnicity: Histologic Subtype: Colon adenocarcinoma Date of Initial Path Dx: Primary Site: Colons Anatomic Site: Cecum T Stage: 3 N Stage: 0 M Stage: 0 Overall Stage: IIA Date of Normal Procurement:. 1cd-0 -3 8140|3 Qdenocaicioma Nosd Sife: Cecun C18.0 (1/12
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diff --git a/output/text/7615c904-62e2-46d6-9d05-ea7f8f2394d9.txt b/output/text/7615c904-62e2-46d6-9d05-ea7f8f2394d9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..95846d5e37da0a1ee8404b54d6fe0161bc562fc6
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:66FB3AA3-97C6-40C6-8A73-D7FE4EFF5FCF TCGA-UZ-A9P3-01A-PR Redacted SURGICAL PATHOLOGY REPORT Patient Name Accession #: Med. Rec.#: Visit #: Service Date: DOb: Sex: Male Received: Soc. Sec. #: Location: Client: Physician(s): Final Pathologic Diagnosis Right kidney, partial nephrectomy: 1. Renal cell carcinoma , papillary type, Fuhrman grade I, 2.5 cm; see comment.. 2. No tumor at inked resection margin. Comment: Kidney Tumor Synoptic Comment -Histologic type: Renal cell carcinoma, papillary type 1. -Grade: Fuhrman grading for RCC: 1: Small nuclei, minute or absent nucleoli. -Maximum tumor diameter: The largest dimension of the tumor submitted to pathology was 2.5 cm,. however, by report the tumor measured 3.1 cm. ICD03 -Site within kidney: upper pole -Renal pelvis: Not present. -Ureter: Not present. NraQ cIQ 8260/3 -Renal sinus: Not present. R Kedney NbS C64.9 -Hilar renal veins: Not present. Sute e -Intrarenal veins and lymphatics: Normal, no tumor. eYj 3|30)i4 -Adrenal gland: Not present. -Capsule/perirenal fat: Tumor does not penetrate capsule. -Hilar lymph nodes (number positive/number of nodes): No lymph nodes identified.. -Resection margins: No tumor. -Proximity to nearest margin: 0.4 cm from kidney resection margin; >lcm from perinephric adipose tissue margin. -Stage: pTlaNXMX. Dr. has reviewed the case and agrees with the diagnosis of papillary renal cell carcinoma.. Specimen(s) Received A:Right renal mass Page 1 of 2
+
+--- Page 2 ---
+Clinical History The patient is a  year-old male with a 3.1 cm right renal mass, who undergoes right partial nephrectomy. Gross Description The specimen is received fresh, labeled with the patient's name and medical record number, and consists of a partial nephrectomy specimen, which has pulled away, intraoperatively, from the main tumor mass. The specimen weighs 70 gm and consists of tan kidney parenchyma with a small amount of white-yellow, friable tumor. This portion of the specimen measures 1.9 x l.3 x 2.3 cm. Additionally, there is a separate fragment of tumor of the same quality which measures approximately 2.5 cm in diameter. There is also detached perinephric fat, measuring 9.5 x 5.5 x 2.0 cm. It has a portion of capsule, which is indicated by the surgeon to have been adjacent to the tumor. This portion which was adjacent to the tumor is inked in green. The tumor is O.4 cm from the deep inked resection margin which is inked black. Sectioning through the perinephric fat reveals no candidate lymph nodes. Sections are submitted as follows: Cassette Al: Tumor approaching resection margin. Cassettes A2-A3: Representative sections of tumor. Cassette A4: Representative sections of capsule. Cassette A5: Uninvolved kidney. Diagnosis based on gross and microscopic examinations. Final diagnosis made by attending pathologist following review of all pathology slides. athology Resident Pathologist Electronically signed out on  hif4|4 QUALIFTEC DISQUALIFIED Page 2 of 2
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diff --git a/output/text/76276426-9b85-44cc-bc56-7f2edfa7cc3d.txt b/output/text/76276426-9b85-44cc-bc56-7f2edfa7cc3d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e7ce01aed4cd0892c8b58b5d107f403cba0e1319
--- /dev/null
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+
+--- Page 1 ---
+Department of Pathology Tissue Source Site (TSS) #: Pathology Report DIAGNOSIS (A) RIGHT KIDNEY: RENAL CELL CARCINOMA, CONVENTIONAL, FUHRMAN'S NUCLEAR GRADE 3 (SEE COMMENT) TUMOR CONFINED TO THE KIDNEY. TUMOR MEASURES 5.5 CM IN MAXIMUM DIMENSION. Ureteral, vascular and soft tissue margins are free of tumor. Renal medullary interstitial tumor (0.2 cm). COMMENT The renal cell carcinoma is composed of approximately 70% clear cells and 30% eosinophilic cells. Centrally, the tumor demonstrates an area of marked hyalinization. There is no unequivocal tumor extension into the perinephric adipose tissue. The tumor abuts the renal sinus without invasion into the adipose tissue. GROSS DESCRIPTION (A) RIGHT KIDNEY, EN BLOC - A nephrectomy specimen (18.0 x 10.0 x 9.0 cm). The kidney measures 12.0 x 7.0 x 5.0 cm with attached grossly unremarkable segment of ureter measuring 4.0 cm in length and 0.5 cm in diameter. A 5.5 x 5.5 x 5.0 cm, irregular mass is identified at the lower pole of the kidney. The tumor has variegated cut surfaces. with hemorrhagic areas, a central firm fibrotic tan-yellow area and a peripheral fleshy areas. The tumor appears to abut the. perinephric adipose tissue without unequivocal invasion. The tumor approaches the renal sinuses. However, no gross tumor is. identified in the adipose tissue of renal sinus. No tumor is identified within the renal vein or renal calyces.. Four small tan-white, well-circumscribed nodules measuring 0.3 cm in maximum dimension each are identified within the renal medulla. The rest of the renal parenchyma is unremarkable. No lymph node or adrenal gland is identified. A small portion of the tumor is submitted for possible microscopic study. Specimen photographs are taken. SECTION CODE: A1, resection margins of renal vein, ureter, renal artery; A2, A3, tumor with perinephric adipose tissue; A4-A6, representative sections from the central firm and fibrotic area; A7-A9, representative sections of the tumor from the hemorrhagic area; A10-A12, representative sections of the tumor from the fleshy area; A13, A14, tumor with renal sinus; A15, four small medullary nodules; A16, representative sections of the uninvolved kidney. CLINICAL HISTORY None given. SNOMED CODES T-71000, M-83123
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diff --git a/output/text/763dab00-1d64-42bf-a827-b6239a7956ea.txt b/output/text/763dab00-1d64-42bf-a827-b6239a7956ea.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4ae9b1cea81653bd3497ba79808e25368cb581d8
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:09038444-9BE4-443C-8FEC-07903972F305 Redacted Procedure: adrenalectomy, and lung wedge resection. Gross description: 8 x 4.5 x 4cm, 44.4g, tumor 5.5 x 5 x 4.5cm Diagnosis: adrenocortical carcinoma, 8 per 20 hpf, van Slooten index=25.8, Hough index=3.97 Reference Pathology: Diagnosis: adrenocortical carcinoma infiltrating vena cava, and lung specimen bronchoalveolar carcinoma, Kl67 3% ZcD-o-3 Weiss score: 4 Carcinomo- Cdrenal CertcaI 83/3 Hough score: 2.44 Site. Adrerol Cland Van Slooten score: 12.3 Cor+ex C 74.O tS qfi|13
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diff --git a/output/text/765e9eea-672f-4151-9f20-5d72553e1180.txt b/output/text/765e9eea-672f-4151-9f20-5d72553e1180.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b46ff7afb1728f5c6f10b0054c46b2cac0a91045
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1Cs-0-3 Carcinomn, mfiltnathy ductl, Nos 85isf3 CQcF 9rh: busK,Nos c5o.9 Diagnosis: 1. and 2. Bifocal poorly differentiated invasive ductal carcinoma (tumor diameters: 2.8 and 0.8 cm). Concluding tumor classification: NOS, G III, pT2(mult)N0LovoR0. UUID:DC5B662B-1ADD-4D6E-A6E3-3EF8B922BC71 Redacted TCGA-A8-A07C-01A-PR
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diff --git a/output/text/7662d38d-86f1-494b-9766-227524698c69.txt b/output/text/7662d38d-86f1-494b-9766-227524698c69.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ac406ba3fbe86a50904d928cbe5f628e21857498
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+ICDO PreuomD, srstheleeQ NOS 8120k3 H UUID:E5DA265D-FBA6-4EA0-9383-96C365A9679A 6120(3 D8073 TCGA-4Z-AA82-01A-PR Redacted Csetitehyhet 812013 COCE C67.4 Blsolole NoS. Collect date: CT79 (MM/DD/YYYY) yJ 3(!8f14 PATHOLOGY REPORT: PRIMARY SITE: Bladder "Bladder + prostate + seminal vesicles": Pw TSS, Sfuomour diffeuntrttn= 3O?c . Invasive urothelial carcinoma of high-grade with foci of squamous differentiation . Size of neoplasm: 4.3 x 2.7 x 1.8 cm  Depth of infiltration: up to detrusor muscle . Sanguineous vascular invasion: not detected . Lymphatic vascular invasion: not detected . Perineural invasion: present . Prostate, seminal vesicles, vas deferens, right and left ureteral margins and urethral margin: free of tumor "Right pelvic lymph nodes": . 11 lymph nodes were dissected, one of which is compromised by neoplasia (1/11) without capsular transposition "Left pelvic lymph nodes": . 8 nodes were dissected, all free of tumor (0/8) 2|104
+
+--- Page 2 ---
+V4.00 TCGA Pathologic Diagnosis Discrepancy Form Instructions: The TcGA Pathologic Diagnosis Discrepancy Form should be completed when the puthologic diagnosis documented on the initial pathology report for a cuse submitted for TcGA is inconsistent with the diagnosis provided on the Case Quality Control Form completed for the submitted case.. TSS Identifier...  TSs Unique Patient Identifier:. Tissue Source Site (TSS): Completed Date: Completed By (Interviewer Name on OpenClinica): Diagnosis Information Entry Alternatives Working Instructions Data Element Provide the diagnosis/ histologic subtype(s) documented on Pathologic Diagnosis Invasive urothelial carcinoma of high grade with the initial pathology report for this case. If the histology for this case is mixed, provide all listed subtypes. Provided on Initial Pathology Report' foci of squaious differentiation Provide the histologic features selected on the TCGA Case  Histologic features of  High grade urothelial carcinoma with 30% of Quality Control Form completed for this case.  the sample provided squamous differentiation  for TCGA, as reflected on the CQCF. Discrepancy between Pathology Report and Case Quality Control Form Provide a reason describing why the diagnosis on the initial Provide the reason for  pathology report for this case is not consistent with the the discrepancy diagnosis selected on the TCGA Case Quality Control Form. between the pathology Case reviewed by based on  report and the TCGA top slide image sent from BCR. Case Quality Control Form.  Provide the name of the pathologist who reviewed this case Name of TSS Reviewing for TCGA. Pathologist or Biorepository Director I acknowledge that the above informution provided by my institution is true and correct and has been quality controlled. Date Tss Reviewing Pathologist or Biorepository Director I acknowledge that the above inforimation provided by my institution is true und correct und has been quulity controlled. The Attending Puthologist or the Department Chairman has been informed or is aware of the above discrepancy in diognoses. Principal Investieator Signaturee Date
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diff --git a/output/text/76caf189-2385-43c0-a82d-fd2707e3bc20.txt b/output/text/76caf189-2385-43c0-a82d-fd2707e3bc20.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6e01f54215be1516db69a352c9e58f206194d0ad
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+Clinical Diagnosis & History:. y/o female with 4.5 cm right breast mass biopsy positive for intraductal carcinoma. Specimens Submitted: 1: sp: Sentinel node #1, level 1, right axilla (fs) 2: SP: Right breast and level 1, plus low level 2 axillary contents 3: SP: Level 2 right axillary nodes DIAGNOSIS: 1) SENTINEL NODE #1, LEVEL I, RIGHT AXILLA, BIOPSY: - ONE BENIGN LYMPH NODE (O/1). - ADDITIONAL H&E STAINED SECTIONS AND IMMUNOHISTOCHEMICAL STAINS FOR CYTOKERATINS (AE1:AE3) SHOW NO EVIDENCE OF METASTATIC TUMOR.) 2)  BREAST, RIGHT LEVEL I AND LOW LEVEL II AXILLA CONTENTS. MODIFIED RADICAL MASTECTOMY: - INVASIVE DUCTAL CARCINOMA, NOS TYPE, HISTOLOGIC GRADE III/III (SLIGHT OR NO TUBULE FORMATION). NUCLEAR GRADE II/III (MODERATE VARIATION IN SIZE AND SHAPE), MEASURING 5.O CM IN LARGEST DIMENSION GROSSLY, SEE NOTE. - THE INVASIVE CARCINOMA IS LOCATED IN THE UPPER OUTER QUADRANT AND LOWER OUTER QUADRANT. - NO INVOLVEMENT OF THE NIPPLE BY CARCINOMA IS IDENTIFIED.S - NO DEFINITE EVIDENCE OF VASCULAR INVASION OF CARCINOMA IS NOTED. - THERE IS PERINEURAL INVASION OF CARCINOMA. - NO INVOLVEMENT OF THE SURGICAL MARGINS BY INVASIVE CARCINOMA IS IDENTIFIED. - NO SKIN INVOLVEMENT BY CARCINOMA IS IDENTIFIED. - THE NON-NEOPLASTIC BREAST TISSUE SHOWS BIOPSY SITE CHANGES,S FIBROCYSTIC CHANGES WITH FLORID DUCTAL HYPERPLASIA AND FIBROADENOMA (1.6 CM) WITH COARSE MICROCALCIFICATIONS. - ONE BENIGN INTRAPARENCHYMAL LYMPH NODE (O/1). - THE LYMPH NODE STATUS IS AS FOLLOWS (EXPRESSED AS THE NUMBER OF POSITIVE LYMPH NODES IN RELATION TO THE TOTAL NUMBER OF LYMPH NODES EXAMINED): LEVEL I: 0/5. - RECEPTOR IMMUNOHISTOCHEMISTRY DEMONSTRATES THE FOLLOWING STAINING PATTERNS FOR THE INVASIVE CARCINOMA: ESTROGEN RECEPTOR (ER) POSITIVE, 95% NUCLEAR STAINING WITH STRONG INTENSITY; PROGESTERONE RECEPTOR (PR) POSITIVE, 50% NUCLEAR STAINING WITH MODERATE TO STRONG INTENSITY; AND HER2/NEU ** Continued on next page ** 1cs-0 -3 corciiont,mifiltretry duct, Nos 850013 Site : breaot, Nss. C 50.9 UUID:A1F0FEB5-6FEF-4FF7-AA1E-8EAAE551138B TCGA-AO-A03C-01A-PR Redacted Criterla Jual's 10/22/t1
+
+--- Page 2 ---
+(HERCEPTEST) NEGATIVE, STAINING INTENSITY OF O. CONTROLS ARE SATISFACTORY. nOtE:  THE RESULTS OF OTHER IMMUNOHISTOCHEMISTRY STAINS SUPPORT THE ABOVRS DIAGNOSIS.  SPECIFICALLY, THE TUMOR CELLS ARE POSITIVE FOR CYTOKERATIN 7, BRST-2, AND B-CADHERIN. WHERBAS THE TUMOR CELLS ARE NEGATIVE FOR CK20, SMA, HHF35, SYNAPTOPHYSIN AND CHROMOGRANIN. LYMPH NODES, LEVEL II, LEFT AXILLA, DISSECTION: FIVE BENIGN LYMPH NODES (O/5). I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. *** Report Blectronically Signed Out ** Special Studies: Result Special Stain AE1:AE3 ment IMM RECUT NEG CONT ER-C PR-C CMA (HHF35) SMA HER2-C CK7 CK20 BR2(gCDFp) CHR SYN SYN E-CADHERIN IMM RECUT NEG CONT NEG-HER2 Gross Description: M.D. 1). The specimen is received fresh for frozen section consultation, labeled "Sentinel node number one, level I, right axilla" and consists of two pink. tan fatty lymph nodes measuring 1 x 1 x 0.7 and 0.5 x 0.5 x 0.4 cm. The largest lymph node is bisected, and the small lymph node is inked in blue.. Entirely submitted for frozen section. Summary of sections: FSC -- frozen section control. M.D. ** Continued on next page **
+
+--- Page 3 ---
+2). The specimen is received fresh labeled, "Right breast and level I and. low level II axillary contents" and consists of a breast with attached axillary tail. The breast measures 28.5 x 26 x 4.0 cm with overlying skin ellipse measuring 2.5 x 1.1 cm. Situated centrally on the skin surface is an everted nipple measuring 1.2 x 1.1 x 0.4 cm and areola measuring 4 x 4. cm. The skin is grossly fixed and involved by a mass lesion measuring 5.0 x. 4.5 x 3.7cm situated in the upper and lower outer quadrants between 8 o' clock to 10 o' clock . A suture demarcates the axillary tail which measures 8 x 7 x 1 cm. No tags are present. inked black and the specimen is serially sectioned to reveal the mass is The posterior surface of the breast is abutting the posterior margin. The remaining breast tissue shows fibrofatty cut surface. The axillary tissue is dissected to reveal multiple lymph nodes, ranging in size from 0.3 cm to 1.5 cm. Representative sections are Submitted, including all identified lymph nodes. has an irregular skin ellipse and subcutaneous tissue measuring 9.5 x 8.5 x Additionally the container 1.5 cm with overlying skin measuring 8.5 x 6 cm which is grossly unremarkable.  Serial sectioning reveals unremarkable fatty cut surface. Summary of sections: N - nippl. NB - nipple base S - skin scar. D -  deep margin T - tumor  quadrant lower inner  quadrant uOQ - 1 upper  outer quadrant LOQ - lower  outer g quadrant LN - single lymph nodes BLN - bisected lymph nodes m M.D. 3).The specimen is received in formalin and is labeled "Level II right. axillary nodes". It consists of fragments of fibroadipose tissue measuring 5.5 x 3.5 x 1.5cm without orientation. ranging in size from 0.5 cm to 1.5 cm.  Multiple lymph nodes are identified, submitted.  All identified lymph nodes are Summary of sections: LNS - whole lymph nodes Summary of Sections: Part 1: Sp: Sentinel node #1, level 1, right axilla (fs) Block Sect. Site 1 PCs Fsc 1 Part 2:  SP: Right breast and level 1,  plus low level 2 axillary contents ** Continued on next page **
+
+--- Page 4 ---
+Blo Sect. Site PCs bln d liq 1 1n 1oq s t uiq 2 uoq 2 Part 3: SP: Level 2 right axillary nodes Block Sect. Site PCs 2 1ns Procedures/Addenda: Addendum Date Ordered: Date Complete Status: Signed Out Date Reported. By: MD Addendum Diagnosis 2) BREAST, RIGHT LEVEL I AND LOW LEVEL II AXILLA CONTENTS; MODIFIED RADICAL MASTECTOMY: - THE ORIGINAL DIAGNOSIS ON THIS CASE REMAINS UNCHANGED. THIS ADDENDUM SERVES TO CLARIFY THAT, ON REPRESENTATIVE SECTIONS, THE INVASIVE CARCINOMA APPROACHES THE EPIDERMIS OF THE BREAST SKIN, BUT DOES NOT DIRECTLY INVOLVE THE EPIDERMIS. Intraoperative Consultation: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS: PERMANENT DIAGNOSIS: NEGATIVE LYMPH NODE.  SAME ** Bnd of Report **
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diff --git a/output/text/76d265da-3387-48d9-8f2e-39fe0f026496.txt b/output/text/76d265da-3387-48d9-8f2e-39fe0f026496.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5a1fc5ed0a7ba8a069d07ec962da814948692f34
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:36A90083-5078-435F-B9C2-337B758077160 Redacted Patient ID: Surgical Date: Gross Description: Tumor is located and limited in cervix. It is protruded occupying lumen, with 4x3.5x3.5cm in size, soft and white-gray surface. Microscopic Description: Squamous cell are hyperplastic to replace normal squamous cells and infiltrates in muscle propria. Tumor tissue arranges in the form of group or broad sheets or trabecular of tumor cells. The malignant cells have abundant, light eosinophilic cytoplasm. The nuclei are fairly enlarged, variability in size and shape, containing coarse clumped chromatin with prominent nucleoli.. Mitotic figures are present. Stroma is invasion of lymphocytes.. Diagnosis Details: Squamous celll carcinoma, Grade Ii, infiltrating complete muscle propria. ICDo3 Comments: Formatted Path Reports: CERVIX TISSUE CHECKLIST 8870L3 Couiyi NCE539 Sute Specimen type: Hysterectomy Tumor site: Cervix YJ 8/2()13 Tumor size: 4 x 3.5 x 3.5 cm Histologic type: Squamous cell carcinoma Histologic grade: Moderately differentiated Tumor extent: Lesion less than 4.0 cm. Lymph nodes: Not specified Lymphatic invasion: Present Venous invasion: Not specified Margins: Uninvolved Evidence of neo-adjuvant treatment: Not specified. Additional pathologic findings: Not specified Comments: None 8/14/!3
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diff --git a/output/text/76fe0d62-4638-4583-a88d-3941bc9a2159.txt b/output/text/76fe0d62-4638-4583-a88d-3941bc9a2159.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3f4844b406b64fb9606431620bc4f90f9e6e90d9
--- /dev/null
+++ b/output/text/76fe0d62-4638-4583-a88d-3941bc9a2159.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+UUID:63E2F152-246D-43A2-8E02-D8F69FFBFBEF Print Date: TCGA-TS-A8AV-01A-PR Redacted Date Collected: Date Received years Sex: Male Accession Physician: Copy to: Surgical Pathology Report  Collection Date/Time Received Date/Time Verified Date/lime Pathologist Accession Number Clinical Information year old male with mesothelioma; Thoracotomy, Right PDT, Bronchoscopy, Radical Pleurectomy. ID-0.3 Final Diagnosis 1. SKIN, PREVIOUS INCISIONAL AREA,EXCISION: Site:yLewo Ni05 C38 4 Representative section of skin showing dermal fibrosis. No evidence of residual tumor. Y 5/Z8/14 2.RIB Benign cancellous bone containing unremarkable bone marrw elements. Adherent benign fibroadipose tissue and striated muscle. 3.LEVEL 4: Four of multiple fragments of lymph node, positive for metastatic malignant mesothelioma.. 4.LEVEL9: Fibroadipose showing nodular foci of sarcomatoid malignnant mesothelioma with focal areas of necrosis. Scant compressed lymphoid tissue noted at the peripheral of nodules. Scant benign adherent lung parenchyma also present. 5. LEVEL 10: One lymph node,positive for metastatic malignant mesothelioma. 6. LEVEL 2: One lymph node,positive for metastatic malignant mesothelioma. Other fragment of tissue containing scant lung parenchyma showing nodular malignant mesothelioma.. 7. PLEURA: Malignant mesothelioma,sarcomatoid type with areas of necrosis. Tumor invades the adjacent lung parenchyma. 8. LUNG,WEDGE RESECTION: Benign alveolar lung parenchyma. 9. LUNG IMPLANT: Malignant mesothelioma,sarcomatoid type. 10. LEVEL 7: Name Page 1 of 4 MRN
+
+--- Page 2 ---
+Print Date: Date Collected: Date Received:: gc:. years Sex: Male Accession No. Physician: Copy to: Surgical Pathology Renort Collection Date/Fime Received Date/Time Verified Date/Time Pathologist Accession Number One ot many lymph nodes,positive for metastatic malignant mesothelioma.. 11. PLEURAL PLAQUE: Hyalinized pleural tissue with presence of malignant mesothelioma ,sarcomatoid type.. 12. POSTERIOR INTERCOSTAL: One of two lymph nodes,positive tor metastatic malignant mesothelioma.. 13. POST TREATMENT DIAPHRAGM: Benign tibroadipose tissue with acute intlammation.. Negative for malignancy. The case material was reviewed and the report verified by:. (Electronic signature) Verification Date: Note  Immunostains with adequate controls pertformed on three blocks reveal tumor cells are diffusely and strongly positive for Cam5.2 and,AE1-3. Tumor cells are focally positive for D2-40,calretinin, WT-1 and thrombomodulin.Tumor cells are negative for TTF-1,Mic-2,Bcl-2 and desmin. See disclaimer: Disclaimer: The above in-vitro IHC tests may have used reagents labeled for IVD (In Vitro Diagnostic Use), IUO (Investigational Use Only) and/or RUO (Research Use Only) and have not been cleared or approved by the U.S Food and Drug Administration. However, the FDA has determined that such clearance or approval is not necessary for ASR class I tests intended to provide pathologists with adjunctive information to assist their morphologic evaluation. The tests using IUO or IUO reagents were developed and their performance characteristics were validated for diagnostic use by the This laboratory is regulated under the Clinical Laboratory Improvement Amendments of 1988 (CLiA) as qualitied to perform high complexity clinical tests. These Class I ASR tests are not intended to provide diagnostic, prognostic, predictive or therapeutic information that is not directly contirmed by routine histopathologic internal or external control specimens. Frozen Section Diagnosis FS1: Muitiple representative sections (6) fragments submitted. No evidence of tumor. Name Page 2 of 4 MRN!
+
+--- Page 3 ---
+Print Date: Date Collected: Date Received years Sex: Male Accession N Physician: Copy to: Surgical P a thoIo g y Repori Collection Date/Time Received Date/Time Verified Date/Time Accession Number Pathologist FS2A, Fs2B: Malignant tumor present suggestive of sarcomatoid portion of malignant mesothelioma.. Gross Description The specimen is received in 13 parts in a container labeled with the patient's name and medical record number.  Specimen #1 is designated "Previous Incision" and consists of an elongated fragment of skin with the surgical tape measuring 10.0 cm in length. Multiple representative sections are submitted in three cassettes from the frozen section. Specimen #2 is designated *Rib" and consists of a portion of rib measuring 1.5 x 1.5 x 0.5 cm. Representative sections are submitted in one cassette.. Specimen #3 is designated "Level 4" and consists of multiple fragments of yellow-tan adipose tissue measuring in. aggregate 3.0 x 2.0 x 0.5 cm. Within the adipose tissue, at least eight lymph nodes are identified measuring from 0.2 up. to 1.2 cm in greatest dimension. The entire specimen is submitted in two cassettes. Specimen #4 is designated "Level 9" and consists of three pink-tan ovoid firm tissue measuring 1.0, 1.5 and 2.5 cm in greatest dimension respectively. The specimen is bisected and submitted in three cassettes.. Specimen #5 is designated "Level 10" and consists of a single pink to yellow-tan ovoid soft tissue measuring 1.0 cm in greatest dimension. The specimen is bisected and submitted entirely in one cassette. Specimen #6 is designated "Level 2" and consists of two pink-tan ovoid soft tissue measuring 0.9 cm in greatest dimension respectively. The entire specimen is submitted in one cassette.. Specimen #7 is designated "Pleura" and consists of multiple tragments of pink-tan to yellow-tan soft tissue consistent with pleura measuring in aggregate 35.0 cm x 15.0 cm x 6.0 cm. The soft tissue shows muitiple pink-tan tumor nodules measuring from 0.2 up to 5.0 cm. in greatest dimension. Representative sections are submitted in tive cassettes. Specimen #8 is designated *Lung" and consists of a single brown, spongy, unoriented, unstapled lung parenchyma measuring 1.5 x 1.5 x 1.0 cm. The specimen is serially sectioned and submitted entirely in two cassettes.. Specimen #9 is.designated "Lung Implant" and consists of'a single black-tan soft tissue measuring 0.3 cm. The entire specimen is submitted in one cassette.. Name Page 3 of 4 MRN.
+
+--- Page 4 ---
+Print Date: Date Collected: Date Received: years Sex: Male Accession No. Physician: Copy to: Suryical Pathology Report Collection Date/Time Received Date/Time Verified Date/Time Pathologist Accession Nunber Specimen #10 is designated "Level 7" and consists of three black to pink-tan rounded lymph node-like soft tissue. measuring from 0.2 up to 1.5 cm in greatest dimension. Also submitted in the same container is a yellow-tan to black irregular shaped soft tissue measuring 1.2 cm in greatest dimension. The entire specimen is submitted in two cassettes. 10A From the largest lymph node 10B Sott tissue and possible small lymph nodes. Specimen #11 is received fresh for frozen section and designated *Pleural Plaque' and consists of a single fragment of pink-tan membranous soft tissue measuring 5.0 x 3.0 cm in surface dimension and 0.2 up to 0.3 cm in thickness. The most thickened area was formed by nodular lesion and this area measures 1.0 cm in greatest dimension. Representative sections are submitted in two cassettes from the frozen section.. Specimen #12 is designated "Posterior Intercostal' and consists of two lymph nodes measuring 0.5 and 0.8 cm in greatest dimension, respectively. The entire specimen is submitted in one cassette.. Specimen #13 is designated *Post Treatment Diaphragm* and consists of tour pieces of pink-tan to yellow-tan irregular shaped soft tissue measuring in aggregate 2.5 x 2.0 x 0.3 cm. The entire specimen is submitted in one cassette.. Dictated by: Dictated by: Pathologist(s) Name: Page 4 of 4 MRN
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diff --git a/output/text/771f4090-e507-410c-8b46-10c37eafc65c.txt b/output/text/771f4090-e507-410c-8b46-10c37eafc65c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d3dd2ace09dd3897188df867343998c1c2c2fc78
--- /dev/null
+++ b/output/text/771f4090-e507-410c-8b46-10c37eafc65c.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:CD826C0A-8057-4BD6-A79A-51277F0E09A7 TCGA-TQ-A7RW-01A-PR Redacted ID-o 3 $382/3 path0 Nature of material: Brain 94s6/3 Biopsy: Q71.t rsiv NoS Macroscopy C7i.9 QO 16/4|3 Pyramidal portion of brain brain containing spins, measuring 5.0 x 4.5 x 2.7 cm. Cortical surface is brownish, bright, with blood vessels congested. Surgical margins had congested areas. The surface is white, not observing the boundaries between different substances and cortical gray subcortical white. Microscopy Histological sections stained with h & e sections showing brain parenchymal viewing neoplasia glial hypercellular, atypical cells incorporated in the nucleus the oval rounded, chromatin coarse. Neoplastic cells arrange up fashion and diffuse infiltrate the normal brain parenchyma, involving neurons. Sattelitosis peri-neuronal structures and secondary in cortex, featured in cell aggregation perivascular. There conspicuous network slender pots and branched standard "chicken wire". Analyzed there was in an average 1figure of mitosis every 10 fields. It was not not observed necrosis or areas of endothelial proliferation microvascular. The immunohistochemistry was intense neoplasms in positive for anti-gfap and s100 protein. Ki-67 was 6%. Diagnosis: - Oligodendroglioma, grade II Notes - It was not found clear criteria for anaplastic oligodendroglioma diagnosis PROFESSIONAL PARTICIPANTS OF REPORT Pu TSS,dx disoupucq frm Shtu Te6A tnr to oligo artro uytoma, qud IF.  8/33
+
+--- Page 2 ---
+TCGA Pathologic Diagnosis Discrepancy Form 4.05  Study Subject ID: Person ID: N/A!  study/Site: TCGA Brain lower grade glioma- (Brain Lower Grade Glioma)  Age: N/A  Event: PathDiscrepancye Date of Birth: :Interviewer:.  Sex: M Tumor Identifier Provided on Initial Case Quality Control.  Provide the tumor identifier documented on the initial case quality control form for. Form this case.  Pathologic Diagnosis Provided on Oligodendroglioma Provide the diagnosis/ histologic subtype(s) documented on the initial pathology report for this Initial Pathology Report grade II case. If the histology for this case is mixed, provide all listed subtypes. Histologic features of the sample provided for TCGA,.  Oligoastrocytoma Provide the histologic features selected on the TcGA Case Quality Controle as reflected on the CQcF grade II Form completed for this case. Discrepancy between Pathology Report and Case Quality Control Form Provide the reason for the wrotte in TCGA Pathologic Diagnosis Provide a reason describing why the diagnosis on discrepancy between the Discrepancy Form: "This case was iniatially seen by other. the initial pathology report for this case is not pathology report and the TcGA pathologyst. Even though is quite subjective, in my opinion, there consistent with the diagnosis selected on the TCGA. Case Quality Control Form is an astrocytic component (p53+ at IHC)". Case Quality Control Form. Name of Tss Reviewing Pathologist or Biorepository.  Provide the name of the pathologist who reviewed this case for. Director TCGA.
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diff --git a/output/text/77278df2-e1a3-4e71-bef0-78b72bdf6630.txt b/output/text/77278df2-e1a3-4e71-bef0-78b72bdf6630.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ff6ff67d383f6dd530f0cf0bfacf66914c986087
--- /dev/null
+++ b/output/text/77278df2-e1a3-4e71-bef0-78b72bdf6630.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+IcD-o-3 0 854/3 UUID:BB85F844-C710-41D5-8620-E246DC9D2C6A TCGA-A7-A6VY-01A-PR Redacted c50.9 sJ z/25|L3 Final Surgical Pathology Report Procedure: Diagnosis  Right breast, excisional biopsy: Infiltrating ductal carcinoma, grade 3, 3.5 cm in greatest dimension. Invasive carcinoma 1 mm from posterior margin of resection. Ductal carcinoma in situ, solid subtype, nuclear grade 3, accounting for less than 5% of the tumor, margins uninvolved. B. Right axillary contents, resection: Metastatic carcinoma in 2 of 14 lymph nodes, size of largest metastasis 3.4 cm, extracapsular extension present (2/14).. Microscopic Description: Microscopic examination performed. A.  Invasive Carcinoma: present Histologic type: infiltrating ductal cancer Histologic grade: Overall grade: 3 Architectural score: Nuclear score: 3 Mitotic score:. Greatest dimension (pT): 3.5 cm, pT2 Specimen margins:  negative but close, 1 mm from the posterior margin (black in block A6) Vessel invasion: not identified Ductal carcinoma in situ: present Histologic pattern:.  solid Nuclear grade: 3 Central Necrosis: focal % Dcis of total tumor (if mixed): < 5% Extensive intraductal component (present/absent): absent Specimen margins: negative, 3 mm from posterior Calcification: not identified B. Sections of the axillary dissection demonstrate metastatic. carcinoma in 2 of 14 lymph nodes, (pNl). The size of largest. metastasis is 3.4 cm. Extracapsular extension is present.. Specimen A. Right breast mass B. Right axillary contents. Clinical Information. Right breast cancer -year-old black female with right cancer and positive nodes Gross Description Received fresh in a transpec container, subsequently fixed in formalin labeled "right breast mass" is a 6.0 x 5.5 x 4.5 cm yellow pink fatty tissue fragment which has a short suture designating superior and a long suture designating anterior. The margins are inked as follows based upon the orienting sutures: superior - orange; anterior - blue; The specimen is serially
+
+--- Page 2 ---
+sectioned from medial to lateral. There is a 3.5 x 3.2 x 2.5 cm ill circumscribed white tan mass centrally located, and within 0.2 cm of the closest margin (deep). White rice-like pellets or gross identified. in the central which we be grossly consistent with a nrevious biopsy site. The specimen is received in pathology it nd fixed in. formalin and  Representative sections of the specimen are submitted as rosiows: 1 - medial margin perpendicular, 2 - lateral margin perpendicular. of the specimen.. B. Received fresh and subsequently fixed in formalin labeled "right tissue grossly consistent with axillary contents. The specimen has a suture designating superior. Multiple lymph nodes are palpated the largest measuring 3.4 cm and located midway through the specimen. The. highest is markedly indurated as is the largest lymph node. The lymph. nodes are submitted from highest to lowest as follows: 1 -lymph node. bisected, 2 - 3 possible lymph nodes, 3 -  4 - 3 possible lymph nodes each, 5 - representative section of largest positive lymph node,/1 possible lymph node bisected, 7 - 2 possible lymph nodes, 8 - 1 possible lymph node..
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diff --git a/output/text/7728ca38-2757-4e08-b5b2-43c5688c402b.txt b/output/text/7728ca38-2757-4e08-b5b2-43c5688c402b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9d2d36fb222f21567017e55460532c2ed7f8e332
--- /dev/null
+++ b/output/text/7728ca38-2757-4e08-b5b2-43c5688c402b.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Clinical Diagnosis & History year old male with history of painless gross hematuria,US showing right renal mass. Specimens Submitted: 1:SP:Kidney and adrenal,right nephrectomy 2:SP:Lymph nodes,paracaval and interaortocaval; excision DIAGNOSIS: 1.SP:Kidney and adrenal, right;nephrectomy Tumor Type Renal cell carcinoma-Chromophobe type eosinophilic variant Tumor Size: Greatest diameter is 8.5 cm. Local Invasion (for renal cortical types): Involves renal sinus fat Renal Vein Invasion: Not identified Small vessel angiolymphatic invasion also not identified Surgical Margins: Free of tumor Non-Neoplastic Kidney: No significant pathologic changes Adrenal Gland: Not involved LymphNodes: Not identified Staging for renal cell carcinoma/oncocytoma pT3a Tumor invades the adrenal gland or perinephric tissues but not beyond Gerota's fascia Comment: Immunostains for CK7,CD10 and MiB-1 support the above interpretation. 2.SP:Lymph nodes,paracaval and interaortocaval;excision Lymph Nodes: Not involved Number of nodes examined:15 Page 1 of3
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT IATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL).AND THAT I HAVE REVIEWEDAND APPROVED THISREPORT. Special Studies: Result Special Stain Comment CK7 MIB-1Ki-67 CD10 RECUT RECUT RECUT NEG CONT IMM RECUT Gross Description: 1).The specimen is received fresh labeled "right kidney and adrenal" and consists of a kidney with attached ureter,renal vessels and perinephric fat weighing 1005 g in total.The kidney measures 15 x 10.5 x 6.5 cm.The attached ureter measures 9.2 cm in length and 0.5 cm in diameter. The attached renal vein measures 1.1 cm in length and 1.4 cm in diameter. The renal vessels and ureter margins are grossly unremarkable.An adrenal gland is identified,measuring 5.5 x 0.8 x 0.5 cm.The kidney is inked black and bivalved to reveal a cortical, lobulated brown-tan mass measuring 8.5 x 8.5 x 5.5 cm located in the superior pole at the center of the mass there is a white fibrous scar measuring 4.5 cm in greatest dimension.The mass does not appear to invade into the perirenal fat. The mass impinges on the pelvic system but does not appear to grossly involve it.Sections through the remainder of the kidney reveal a pink brown parenchyma,with a well-defined corticomedullary junction.The cortex measures 1.5 cm in largest dimension and the calyces appear normal. No lymph nodes are identified in the perinephric fat. The specimen is photographed. Representative sections are submitted for TPS and for permanent sections. Summary of sections: UVM--ureteral and vessel margins Ttumor THF-- tumor with hilar fat TSF--tumor with sinus fat TK--tumor with adjacent kidney TRP -- tumor with renal pelvis TPF-tumor with peri-renal fat K- representative sections kidney AD-adrenal gland 2).The specimen is received in formalin, labeled Paracaval interaortocaval lymph nodes' and consists of multiple pink and red tan lymph nodes ranging in size from 0.2 to 1.9 cm which are entirely submitted summary of sections: LN-lymph nodes submitted: BLN-bisected largest node Summary of Sections Part 1:SP:Kidney and adrenal, right; nephrectomy Page 2 of3 Page 3of3 ENDOF REPORT
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diff --git a/output/text/7756d86e-08cd-4ce6-83ed-55cce2a18875.txt b/output/text/7756d86e-08cd-4ce6-83ed-55cce2a18875.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3fac77e166b06cd6e4208ff1f4f28a4d81000d5f
--- /dev/null
+++ b/output/text/7756d86e-08cd-4ce6-83ed-55cce2a18875.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+INTERPRETATION AND DIAGNOSIS: 1) TONGUE, DEEP MARGIN (EXCISION) : NEGATIVE FOR TUMOR.) 2) TONGUE MUCOSA, SUPERFICIAL MARGIN (EXCISION) : NEGATIVE FOR TUMOR. 3) NECK, LEFT LEVEL 2 (DISSECTION) : METASTATIC SQUAMOUS CELL CARCINOMA INVOLVING ONE (1) OF SIX (6) LYMPH NODES. 4) NECK LEFT LEVEL 3 AND 4 (DISSECTION) : LEVEL 3: SEVEN (7) LYMPH NODES, NEGATIVE FOR TUMOR.) LEVEL 4: EIGHT (8) LYMPH NODES, NEGATIVE FOR TUMOR. 5) NECK, RIGHT LEVELS 2-4 (DISSECTION): LEVEL 2: METASTATIC SQUAMOUS CELL CARCINOMA INVOLVING ONE (1) OF SEVEN (7) LYMPH NODES. LEVEL 3: NINE (9) LYMPH NODES, NEGATIVE FOR TUMOR.) LEVEL 4: ELEVEN (11) LYMPH NODES, NEGATIVE FOR TUMOR.) 6) LARYNX (TOTAL LARYNGECTOMY) : SPECIMEN: Laryngectomy, neck dissection TUMOR SITE: Supraglottis HISTOLOGIC TYPE: Squamous cell carcinoma. TUMOR SIZE: Greatest dimension 3.2 cm. HISTOLOGIC GRADE: G3: Moderately to poorly differentiated LYMPH NODES: Metastatic carcinoma in 2 of 48 lymph nodes EXTRANODAL EXTENSION:S Not identified EXTENT OF INVASION PRIMARY TUMOR:  FINAL DOCUMENT Page 1 of 5
+
+--- Page 2 ---
+pT3: Tumor invades preepiglottis.. REGIONAL LYMPH NODES: pN2: Metastasis in single or multiple lymph nodes, none larger than 6 cm DISTANT METASTASIS: pMx: Cannot be assessed MARGINS : Margins are uninvolved. Distance of invasive carcinoma from nearest. margin: 1 mm VENOUS/LYMPHATIC INVASION: Present PERINEURAL INVASION: Not identified *Electronic signature by which I attest that the above diagnosis is. based upon my personal examination of the slides (and / or other material indicated in the diagnosis), and that I have reviewed and. approved this report. Clinical History: GROSS DESCRIPTION PART #1: FS: TONGUE DEEP MARGIN Resident Pathologist: FROZEN SECTION DIAGNOSIS: Staff Pathologist: Other Pathologists / FS: TONGUE DEEP MARGIN:  NEGATIVE FOR TUMOR. Dictated by The specimen is received fresh for frozen section labeled with the patient's name, and designated 'tongue deep margin'.. fragment of red tan soft tissue, measuring 1.1 x 0.4 x 0.3 cm. The specimen is entirely submitted for. frozen. SUMMARY OF SECTIONS: 1 - FSC - 1 (TONGUE DEEP MARGIN) 1 - TOTAL - 1 PART #2: FS: TONGUE MUCOSA SUPERFICIAL MARGIN Resident Pathologist: FROZEN SECTION DIAGNOSIS Staff Pathologist: Other Pathologists / FINAL DOCUMENT Page 2 of 5
+
+--- Page 3 ---
+FS: TONGUE MUCOSA SUPERFICIAL MARGIN: NEGATIVE FOR TUMOR. Dictated by The specimen is received fresh for frozen section labeled with the patient's name, and designated 'tongue mucosa superficial margin'. The specimen consists of one (1) fragment of red tan soft tissue measuring 2.0 x 0.3 x 0.2 cm. The specimen is. bisected and entirely submitted for frozen. SUMMARY OF SECTIONS: 1 - FSC (TONGUE MUCOSA SUPERFICIAL MARGIN) 1 -TOTAL - 2 PART #3: LEFT NECK LEVEL 2 Resident Pathologist: Dictated by: received fresh labeled with the patient's name,  and designated 'left neck level II'. The specimen consists of red pink fibrofatty soft tissue measuring 5.7 x 2.3 x 0.7 cm. Blunt dissection reveals two (2) candidate lymph nodes measuring. 0.7 cm and 0.4 cm in diameter. The nodes along with the remaining soft tissue are submitted in entirety. SUMMARY OF SECTIONS: 1 A 2 (TWO CANDIDATE LYMPH NODES) 1 B 2 (REMAINING SOFT TISSUE) 1 C (REMAINING SOFT TISSUE) 2 D-E 2 EA. (REMAINING SOFT TISSUE) 1 F 1 (REMAINING SOFT TISSUE) 6 TOTAL - 10 PART #4: LEFT NECK LEVEL 3 AND 4 Resident Pathologist: Dictated by: received fresh labeled with the patient's name, and designated 'left neck levels 3 and 4'. It consists of red, pink soft tissue, measuring 6.5 x 2.5 x 1.6 cm. Staples are used to designated the levels 3 and 4. The specimen is seperated and each individual level bluntly dissected to reveal three candidate lymph nodes in level 3 ranging in size from 0.5 to 0.3 cm and the two (2) candidate lymph nodes in level 4 measuring 0.5 and 0.3 cm. The lymph nodes and soft tissue are submitted in its entirety. SUMMARY OF SECTIONS: 2 (THREE LYMPH NODES, LEVEL 3) B-C (SOFT TISSUE 2 1 D (TWO LYMPH NODES, LEVEL 4) 3 -E-G EA. (SOFT TISSUE LEVEL 4) 7 -TOTAL PART #5: RIGHT NECK LEVELS 2-4 FInAL DOcUment Page 3 of 5
+
+--- Page 4 ---
+Resident Pathologist:. Dictated by: received fresh labeled with the patient's name,. The specimen and designated 'right neck level 2-4'. It consists. rous soft tissue measuring 15 x 2.5 x 1.1 cm. Levels 2-4 are designated with staples and arbitrarily separated. Blunt dissection reveals two (2) lymph nodes in level 2, and one (1) lymph node in level 3, and five candidate lymph nodes in level 4.  Those along with soft remaining tissue are submitted. The specimen is submitted in its entirety. SUMMARY OF SECTIONS: 2 - A-B 2 EA. (LYMPH NODE BISECTED LEVEL II) 3 - M (SOFT TISSUE LEVEL 2) 1 F 1 (LYMPH NODE, LEVEL 3) 3 G-I EA. (SOFT TISSUE LEVEL ) 1 J 5 (FIVE LYMPH NODE LEVEL 4) 1 M (SOFT TISSUE LEVEL 4) + L-M EA. (SOFT TISSUE, LEVEL 4) 13 - TOTAL M PART #6: TOTAL LARYNGECTOMY Resident Pathologist: Dictated by: received fresh labeled with the patient's name. and designated 'total laryngectomy'. The specimen. consists of a total laryngectomy measuring 10.5 x 8.5 x 6 cm,. including a portion of the hyoid bone measuring 7.5 x 0.3 x 0.3 cm, the larynx from epiglottis to subglottis and three (3) tracheal rings. There is an irregular, firm tan white mass with ulceration measuring 3.1 x 3.2 x 1.6 cm located in the supraglottis and grossly involving the false cord and possibly the true cord. The mass is less than 0.2 cm from the closest mucosal margin (left aryepiglottic fold) and 3.6 cm from the distal tracheal margin. The mass invades into the lamina propria, grossly very close (less than 0.1 to 0.2 cm of the inked margin. The mass does not appear to grossly invade into the serially sectioned red brown strap muscles (which are unremarkable). or into the thyroid cartilage. Along with standard sections, a midline section is submitted for decalcification. Approximately 5% of .the total specimen is submitted. SUMMARY OF SECTIONS: A 1 (EPIGLOTTIS) 1 B (RIGHT ARYEPIGLOTTIC FOLDS) 1 c 1 (LEFT ARYEPIGLOTTIC FOLD) 1 D 1 (TRACHEAL RING) 1 -E 1 (RIGHT ARYTENOID) 1 1 (LEFT ARYTENOID) 1 G (MIDLINE TUMOR) 1 -H (RIGHT INFERIOR TO TRUE VOCAL CORD) 1 I (RIGHT SUPERIOR TO FALSE VOCAL CORD) 1 J (RIGHT THROUGH FALSE AND TRUE VOCAL CORDS) 1 K (LEFT INFERIOR TO TRUE VOCAL CORD) 1 -L (LEFT SUPERIOR TO FALSE VOCAL CORD) 1 - M (LEFT THROUGH FALSE AND TRUE VOCAL CORDS) 1 -N 7 (RIGHT SOFT TISSUE CLOSEST TO TUMOR) FInAL DOCUmEnT Page 4 of 5
+
+--- Page 5 ---
+1 (LEFT SOFT TISSUE CLOSEST TO TUMOR) 1 P 1 (RIGHT CARTILAGE) 1 1 (LEFT CARTILAGE) 1 R (RIGHT STRAP MUSCLE) 1 - s 1 (LEFT STRAP MUSCLE) 19 -TOTAL 19 Other Surqical Pathology Specimens known to the computer: (End of Report) Note: This note provides information pertaining only to a specific event. A more detailed medical history is available in the Medical Record. FINAL DOCUMENT Page 5 of 5
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diff --git a/output/text/77810938-ac9f-4de3-8a84-7065d9fc7eb3.txt b/output/text/77810938-ac9f-4de3-8a84-7065d9fc7eb3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e501d17e789c5c5b22efa18d41e7e28a6f619893
--- /dev/null
+++ b/output/text/77810938-ac9f-4de3-8a84-7065d9fc7eb3.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+DIAGNOSIS: ****CORRECTED REPORT***** Revised report to change and clarify staging in synoptic report; the synoptic. should read: Macroscopic extent of tumor: Tumor limited to kidney. Venous invasion: Indeterminate (see comment): Comment: There are foci within the renal sinus suspicious for vascular invasion. nas reviewed slides C-I and P-S. as reviewed slides C-I and Dr. Right kidney,nephrectomy Oncocytic neoplasm with features most consistent with chromophobe renal cell. carcinoma, see synoptic report. Kidney: Nephrectomy, partial or radical Synopsis MACROSCOPIC Specimen Type: Right radical nephrectomy.
+
+--- Page 2 ---
+Focality: Unifocal. Tumor Size Greatest dimension: 13.8 cm. Macroscopic extent of tumor: Tumor extends into renal sinus vein. MICROSCOPIC Histologic Type: Chromophobe renal cell carcinoma.. EXTENT OF INVASION Primary Tumor: pT2: Tumor more than 7 cm in greatest dimension, limited to the kidney Regional Lymph Nodes:pNX: Cannot be assessed Distant metastasis: pMX: Cannot be assessed Margins: Margins uninvolved by invasive carcinoma.. Adrenal gland: Not present. Venous invasion: Present. Additional Pathologic Findings: None identified ADDENDUM: Tumor stains positively for PAx-2, C-kit and CK7 and Clinical:Right kidney mass. Gross: The specimen is received fresh labeled with the patient's name the medical record number and "right kidney." It consists of a nephrectomy specimen with attached perinephric adipose tissue that measures 25.0 x 15.0 x 7.5 cm overall. A segment of ureter is present that measures 1.0 cm in length. An adrenal gland is not present. The kidney is bivalved.A mass is present that measures 13.8 x 7.0 cm. The mass has replaced the majority of the kidney. The cut surface of the mass has areas that are both solid and cystic. yellow. brown and hemorrhagic with extensive necrosis present. Tumor invasion into the perinephric adipose tissue is not identified. Invasion of the renal vein is not grossly
+
+--- Page 3 ---
+dentified.The tumor does not appeal the renal parenchyma. No lymph nodes are grossly evident. The mucosa of the ureter and. pelvis are unremarkable.The specimen is represented as follows; A = ureter margin, B = vascular margins,C-I = mass,J= normal kidney, K-O = hilar fat (possible lymph nodes), P = mass from region of pelvis, Q-S = mass in relation to perinephric fat.
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diff --git a/output/text/778af309-7109-474b-a34e-ced8d332a928.txt b/output/text/778af309-7109-474b-a34e-ced8d332a928.txt
new file mode 100644
index 0000000000000000000000000000000000000000..14e1f3f60b67282408d5e8a7cf5373f915bf9907
--- /dev/null
+++ b/output/text/778af309-7109-474b-a34e-ced8d332a928.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1cD-0-3 Caltinomn, mfiltnatxq,ductl, nos 85vof3 3/n" page 1 / 1 Department of Cancer Pathology copy No. Date: Examination: Histopathological examination (cito). Examination No.: Patient: PESEt. Age Gender: F Material: Multiple organ resection -- right breast Unit in charge  Physician in charge: Material collected on: Material received on: Expected time of examination: 5 working days Clinical diagnosis:  Examination performed on Macroscopic description:  Right breast, sized 21.3 x 18.6 x 4.8 cm, removed along with axillary tissues sized 10 x 7 x 3.5 cm and a skin flap of 19.2 x 7.1 cm. Weight 923 g. Tumour sized 3.3 x 1.8 x 3.2 cm on the border of outer quadrants, placed 2.2 cm from the lower edge, 0.3 cm from the base and 2.8 cm from the skin. Lymph nodes of 0.4 cm in length, fat.. Microscopic description: Carcinoma ductale invasivum - NHG2 (3 + 3 +2:14 mitoses/10 HPF, visual area diameter 0.55 mm). Mamilla sine laesionibus. Glandular tissue showing mastopathia flbrosa et cystica. (fibrocystic changes) AXILLARY LYMPH NODES Metastases carcinomatosae in lymphonodis (No ill/xvi). Examination result:/Histopathology diagnosis: Carcinoma ductale invasivum mammae dextrae. Invasive ductal carcinoma of the right breast  Metastases carcinomatosae in Iymphonodis axillae (NO /xvi). Cancer metastases in axillary lymph nodes (No Ill/XVI) (NHG2, pT2, pN1a). Compliance validated by:!  Examination performed on Results of immunohistochemical examination: Estrogen receptors found in 75% of neoplastic cell nuclei. Progesterone receptors found in 10-75% of neoplastic cell nuclei. HER2 protein stained with HercepTest'M by DAKO. Negative reaction in.  invasive cancerous cells ( Score = 0) Compliance validated by: UUID:E8E799F8-158D-4AEC-8F86-D40F132C071C TCGA-D8-A138-01A-PR Redacted
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diff --git a/output/text/77ac1aad-917e-4abf-b217-d456c9bafcbb.txt b/output/text/77ac1aad-917e-4abf-b217-d456c9bafcbb.txt
new file mode 100644
index 0000000000000000000000000000000000000000..dc7fc8f0bc673348084fb0247dcad64eaf44a0c8
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:A2B05D26-AC8E-4439-B32C-B48537D20836 TCGA-BH-A8FZ-01A-PR Redacted FINAL DIAGNOSIS: Collection Dato: Part 1: breast, Left, segmental mastectomy at 2 O'clock - A. INVASIVE LOBULAR CARCINOMA, CLASSICAL TYPE.E 8. nOtTingham graDe 2 (tubule formaTIOn 3, nuclear Atypia 2, mitotic Activity 1; total score 6/9).  INVaSIVe TUmOR mEASUReS 1.6 Cm In LARGESt DImeNSIOn (GROSS mEASUREmeNT). D.  NO LYMPHOVASCULAR IDENTIFIED. E.  INvaSIVe TumOR iS 1 mm tO the CLOSESt AnTeriOr mArgIn. F. LOBULAR CARCINOMA IN-SITU AND ATYPICAL LOBULAR HYPERPLASIA. G.  NON-NEOPLASTIC BREAST TISSUE SHOWInG FIBROCYSTIC CHAnGE, SCLEROSiNG ADENOSIS, AND MICROCALCIFICATIONS. H. BIopSy SIte ChanGE.  INVASIVE TUMOR POSITIVE fOR ER, PR AND EQUIVOCAL fOR HER-2INEU 1 PArt 2: AXIlLARy SenTinel Lymph NODe #1, LEft, BIOpSy  FIVe Lymph nODeS, NEGaTiVE fOR mEtaStaTIC CARcInoma (0/5). PARt 3: AXILLARy SENTInel Lymph NODE #2, LEft, BIOpSy -- One Lymph NODE, nEgaTIVE fOr mETASTaTIc CarcinOma (0/1). Part 4: AxillaRy non-SenTinel Lymph node tissue, Left, biopSy. One LyMph NOdE, NEGaTIVE FOR meTASTATIC CARCiNOMA (O/1). CASE SYNOPSIS:  SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREASTE LATERALITY: Left PROCEDURE:  Segmental LOCATION: Clock position:2 SIZE OF TUMOR:  Maximum dimension invasive component: 16 mm.  MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: IcDo3 No TUMOR TYPE (invasive component): arenoma, Ssleels iiyusteler  Infiltrating lobular carcinoma HiStOLOGIC TYPe: 8&20/3 Classical No S nOTTinGhAm SCOre: Nuclear grade: 2 Tubule formation: 3 Ctcr Mitotic activity score: 1 Total Nottingham score: 6 Nottingham grade (1, 2, 3): 2 pa FK ANGIOLYMPHATIC INVASION: No DERmAl LympHATiC iNVASION: Not applicable CALCIFICATION: Yes, benign zones C 50.4 Tumor type, In sitU: LCIS puedssy  SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No  i|z4|3 Lymph nODes POsITIVE: Lymph NOdes exAmineD: 7 method(s) Of Lymph nOde examinatiOn: H/E stain NON-NEOPLASTIC BREAST TISSUE: ALH, FCD t Stage, PatholOgIc: pT1c N stage, pathologic: pNO M Stage: Not applicable ESTROGEN RECEPTORS: positive, H-score: 180 PROGESTeROne rEceptORS: positive, H-score: 75 HER2/NEU: 2+
+
+--- Page 2 ---
+Addendum Part #1: HER-2/NEU IMMUNOHISTOCHEMISTRY [NEGATIVE:0,1+; EQUIVOCAL: 2+; POSITIVE: 3+] RESULT SCORE HER-2/NEU  Equivocal 2+ NOTE: HER2 FISH is being performed and the results will be subsequently reported. block, 4B5 antibody clone is used as part of FDA approved.  interpreted as follows: Score 0 (negative) = No staining is observed or membrane staining is observed in less than 10% of the and tumor cells. Score 1+ (negative) -- A faint/barely perceptible membrane staining is detected in more than 10% of the tumor cells. The cells are only stained in part of their membrane. Score 2+ (equivocal) -- A weak to moderate complete membrane staining is  observed in more than 10% of the tumor cells. This score requires reflex testing by FISH. Score 3+ (positive) - A strong complete  membrane staining is observed in more than 30% of the tumor cells.. SPECIAL PROCEDURES: FISH Interpretation nuc ish(D17Z1x2~5,ERBB2x2-8)[40]  No amplification of the HER-2/NEU gene was seen by interphase FiSH analysis.. RESULTS: Fluorescence in situ hybridization (FiSH) analysis was performed on a formalin-fixed Biock 1H (ieft segmental mastectomy @ 2:00)  using the DNA probe for the HER-2/NEU gene  An adequate number of invasive tumor cells were.  present and evaluated by two independent observers. The ratic of HER-2/NEU signals (ERBB2) to chromosome 17 centromere signals (D17z1) was determined to be 1.34. A ratio of greater than 2.2 is considered to be amplified; therefore, thls specimen is not amplified. Athough amplification was not seen, many of the cells exhibitod 3 or more signals for both the HER-2/NEU gene and for the chromosome 17 centromere. This may be indicative of either polyploidy or aneuploidy for chromosome 17. The average number of HER-2/NEU signals per cell was 3.26. The average number of signals for the chromosome 17 centromere was 2.44. Concurrent positive and negative control specimens showed the expected results.. This FiSH test is performed using a modification of the.  FDA approved HER-2 DNA Probe Kit (1:2 LSI HER-2/neu / CEP17 probe : T-denhyb-2 buffer). This FiSH test was developed and its performance determined by the. Pursuant to the requirements of CLIA '88, this laboratory has established and verified the test's. accuracy and precision. ual/Syn
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diff --git a/output/text/77bd878e-0518-4e1d-8040-e05d74451f9e.txt b/output/text/77bd878e-0518-4e1d-8040-e05d74451f9e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..bdf0877c582797ee2a02ecbc303275f8dce3486f
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Tumor: Normal: Diagnosis: Low Grade Oligodendroglioma (who grade II) MIB-1 LI= 13.4% Addendum Discussion: Numerous MIB-1 reactive cells are scattered throughout. A labeling index of 13.4% is. calculated. This is indicated of a highly proliferative neoplasm and differs from the low grade histologic features seen on the H&E section. The MIB-1 does demonstrate a few. mitotic figures which were not identified previously. However, their number never exceeds 2 per 10 high power fields and is not sufficient to warrant classification as anaplastic. Microscopic Description: Sections demonstrate a focally markedly hypercellular glial neoplasm that diffusely infiltrates both gray and white matter. There is focally prominent intratumor hemorrhage.. The neoplasm is composed of cells with mildly enlarged, mildly atypical round nuclei,. most often with perinuclear halos. No mitotic figures are seen. There is no microvascular proliferation or necrosis.
\ No newline at end of file
diff --git a/output/text/77bdec24-2056-46cd-8e40-0b743df4926c.txt b/output/text/77bdec24-2056-46cd-8e40-0b743df4926c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..285bc1efa04ad424082f754e450adb8a1d6f637a
--- /dev/null
+++ b/output/text/77bdec24-2056-46cd-8e40-0b743df4926c.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+1cs-0- 3 Curcioma mfiltratiny ductal, Nos 85co/3 S,t: bust, Nos c5o.9 1/20/! FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: FMP/SSN: Specimen #: DOB/Age/Sex: lace: WHITE Location: Taken: Physician(s) : Received: Reported: * * AMENDED* * SPECIMEN: A: RIGHT BREAST B: RIGHT BREAST TISSUE FROM INFERIOR FLAP C: RIGHT SENTINEL LYMPH NODE #1 D: RIGHT SENTINEL LYMPH NODE #2 UUID:57153075-9055-4D7E-9CD6-9167D165E860 TCGA-A2-A0CZ-01A-PR Redacted FINAL DIAGNOSIS: A. RIGHT BREAST, MASTECTOMY: -TUMOR TYPE: INVASIVE DUCTAL CARCINOMA WITH LOBULAR FEATURES. -NOTTINGHAM GRADE MODERATELY DIFFERENTIATED (G2). -NOTTINGHAM SCORE: 6/9 (TUBULES = 3, NUCLEI = 2, MYTOSES= 1). -TUMOR SIZE: GREATEST DIMENSION: TUMOR 1 (UPPER INNER QUADRANT): at leaSt 1.1 CM (measured on microscopic slide, extensively involves margin) TUMOR 2 (CENTRAL MASS): 2.5 CM (MEASURED GROSSLY). -TUMOR NECROSIS:  ABSENT. -MICROCALCIFICATIONS: ABSENT. -VENOUS INVASION: ABSENT. -MARGINS : INVASIVE TUMOR EXTENSIVELY INVOLES THE SUPERFICIAL (ANTERIOR, BLUE INK) MARGIN, UPPER INNER QUADRANT (SLIDES A2-A4). INTRADUCTAL COMPONENT NEAREST INKED SURGICAL MARGIN:  5 MM (SUPERIOR, ANTERIOR, SLIDE A2). -INTRADUCTAL COMPONENT MINIMAL. -LYMPH NODES REPORTED SEPARATELY BELOW IN C AND D. -NIPPLE INVOLVEMENT: ABSENT. -SKIN INVOLVEMENT: ABSENT. -MULTICENTRICITY: PRESENT. -ADDITIONAL STUDIES: (See comment.) -TUMOR 1, UPPER INNER QUADRANT: ESTROGEN RECEPTOR: POSITIVE (95% NUCLEAR STAINING) PROGESTERONE RECEPTOR: POSITIVE (5% NUCLEAR STAINING) HER-2 BY IMMUNOHISTOCHEMISTRY: -TUMOR 2, CENTRAL: NEGATIVE (1+) ESTROGEN RECEPTOR: POSITIVE (95% NUCLEAR STAINING) PROGESTERONE RECEPTOR POSITIVE (15% NUCLEAR STAINING) HER-2 BY FISH NOT AMPLIFIED RATIO 1.1. Page 1 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 Continued on Next Page
+
+--- Page 2 ---
+FOR OFFICIAL USR ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORTS Patient:. Specimen #: FINAL DIAGNOSIS (continued): (ESTROGEN RECEPTOR, PROGESTERONE RECEPTOR, AND HER-2 STUDIES WERE PERFORMED ON AN EARLIER BIOPSY AT SCOTTSDALE PATHOLOGY CONSULTANTS, ACCESSION -PATHOLOGIC STAGE: pT2NO(i-)MX -ADDITIONAL PATHOLOGIC CHANGES: COLUMNAR CELL CHANGE. CYSTIC CHANGE, APOCRINE METAPLASIA, B. RIGHT BREAST TISSUE FROM INFERIOR FLAP, EXCISION: -NO SIGNIFICANT PATHOLOGIC CHANGE. C. SENTINEL LYMPH NODE #1, BIOPSY: -NO METASTATIC DEPOSIT IDENTIFIED IN ONE EXAMINED LYMPH NODE (MULTIPLE SLIDES STAINED WITH HEMATOXYLIN&EOSIN AND WITH IMMUNOSTAIN FOR CYTOKERATIN) D. SENTINEL LYMPH NODE RIGHT AXILLA #2, BIOPSY: -NO METASTATIC DEPOSIT IDENTIFIED IN ONE EXAMINED LYMPH NODE (MULTIPLE SLIDES STAINED WITH HEMATOXYLIN&EOSIN AND WITH IMMUNOSTAIN FOR CYTOKERATIN) COMMENT : The smaller tumor in the upper inner quadrant is present at the margin and involves an inked surgical margin over a cut arc of 4 to 5 mm. Because. the greatest extent of the tumor cannot be assessed, this tumor might otherwise be classified pTx. The cenral mass appears to be larger and is. completely excised. Its greatest dimension of 2.5 cm is the basis of the. pathologic T stage of pT2. AMENDMENT COMMENT The report is amended to add evaluation of markers (ER, PR, Her2) performed on the upper inner quadrant tumor, sections of block A2. studies reported for the central tumor are from the report of a biopsy designated "12:0o" at another institution.  The ** Report Electronically Signed Out * Page 2 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 Continued on Next Page.
+
+--- Page 3 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 NTER SURGICAL PATHOLOGY REPORT Patient: Specimen #: CLINICAL DIAGNOSIS AND HISTORY: breast cancer year old female GROSS DESCRIPTION: A. Received fresh labeled with the patient's name designated "RIGHT MASTECTOMY sPECIMEN" is a 278 gram right mastectomy oriented with short stitch superior, long lateral and double deep. The specimen measures 16 cm medial to lateral, 14 cm superior to inferior and 3 cm anterior to posterior. The lightly pigmented superficial skin ellipse measures 10 x 3 cm and displays a 1.7 cm everted nipple free of discharge. No scars are noted. The deep margin is inked black and the superficial surface of the upper inner quadrant is inked blue. Serially sectioned to reveal a 0.6 x 0.4 x 0.3 cm firm pink white mass abutting the superficial margin of the UIQ (1:oo). The cut surface shows focal congestion consistent with a previous biopsy. The mass comes to within 2.0 cm of the deep margin. Located approximately 1.0 cm lateral to this mass is a very poorly defined mass of similar appearance which measures 2.5 x 2.5 x 1.0 cm and involves the upper mid and central portions of the breast. The central mass comes to within 1.0 cm of the deep margin. The remainder of the specimen is composed of moderately dense markedly nodular fibrous tissue. The adipose tissue compromises 20% of the specimen is unremarkable. No lymph nodes are identified. Summary of sections: Al: one piece, skin A2-A4: one piece in each, upper inner quadrant mass anterior margin A5: one piece, central mass deep margin. A6: one piece, central mass A7: upper outer quadrant A8: lower outer quadrant A9: lower inner quadrant A10: upper inner quadrant All: one piece, nipple A12-A13: one piece each, representative mass. 13CF Matched sections of A1-A2 and A6-A10 are submitted in protocol. for CBCP B. Received in formalin labeled with the patient's name designated "BREAST TISSUE FROM INFERIOR FLAP" are multiple pieces of yellow tan lobulated adipose tissue measuring 4.7 x 3.5 x 2.0 cm in. aggregate dimension. Sectioning reveals grossly unremarkable fibroadipose tissue throughout. Representative sections submitted. Summary of sections: B1-B4: one piece in each, 4C4. C. Received fresh labeled with the patient's name Page 3 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 4 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974S SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION (continued) : designated "SENTINEL LYMPH NODE #1" is a single 2 x 1 x 0.3 cm pink yellow lymph node. On sectioning cut surface shows a fatty hilum. The specimen is bisected and entirely submitted in c1 and c2. Summary of sections: c1-c2: one piece in each, suspected lymph node.. D. Received in formalin labeled with the patient's name. designated "SENTINEL NODE RIGHT AXILLA #2" is a single 1.1 x 1.0 x 0.5 cm pink yellow lymph node. On sectioning the cut surface shows a fatty hilum.. The specimen is bisected and entirely submitted in one cassette. Summary. of sections: D1: two pieces. Page 4 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974S End of Report
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diff --git a/output/text/77caf1ae-ba19-45c6-b83e-0a8241ab13bc.txt b/output/text/77caf1ae-ba19-45c6-b83e-0a8241ab13bc.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7ecba65138d927b85b51944df5e5023f422a1c5b
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@@ -0,0 +1,12 @@
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+Clinical Diagnosis & History:. year old woman with right breast mass s/p core bx -- IfDc poorly differentiated. Specimens Submitted: UUID:FE9C56C4-B6D4-4054-A58C-13642370052E : SP: Sentinel node #1, level 1, rt. axilla (fs) TCGA-AO-A030-01A-PRE 2: SP:  Sentinel node #2, level 1, rt. axilla (fs) Redacted 3: SP: Rt. breast 1 DIAGNOSIS: 1) SENTINEL LYMPH NODE #1, LEVEL I, RIGHT AXILLA; BIOPSY: - ONE BENIGN LYMPH NODE (O/1). - ADDITIONAL H&E STAINED SECTIONS AND IMMUNOHISTOCHEMICAL STAINS FORS CYTOKERATINS (AE1:AE3 AND CAM 5.2) SHOW NO EVIDENCE OF METASTATIC TUMOR. 2) SENTINEL LYMPH NODE #2, LEVEL I, RIGHT AXILLA; BIOPSY: - ONE BENIGN LYMPH NODE (O/1). - ADDITIONAL H&E STAINED SECTIONS AND IMMUNOHISTOCHEMICAL STAINS FOR CYTOKERATINS (AE1:AE3) AND CAM 5.2) SHOW NO EVIDENCE OF METASTATIC TUMOR. 3) BREAST, RIGHT AND LEVEL I LYMPH NODES; MASTECTOMY AND AXILLARY DISSECTION: - INVASIVE DUCTAL CARCINOMA, NOS TYPE, HISTOLOGICAL GRADE III/III (SLIGHT OR NO TUBULE FORMATION). NUCLEAR GRADE III/III (MARKED VARIATION IN) SIZE AND SHAPE), MEASURING 3.5 CM IN LARGEST DIMENSION GROSSLY. - DUCTAL CARCINOMA IN SITU (DCIS) IS ALSO IDENTIFIED, SOLID TYPE, WITH HIGH) NUCLEAR GRADE AND EXTENSIVE NECROSIS. TOTAL TUMOR MASS.S THE DCIS CONSTITUTES <= 25% OF THE  THE INVASIVE CARCINOMA IS LOCATED IN THE UPPER OUTER QUADRANT - NO INVOLVEMENT OF THE NIPPLE BY EITHER IN SITU OR INVASIVE CARCINOMA IS IDENTIFIED. - CALCIFICATIONS ARE PRESENT IN THE IN SITU AND INVASIVE CARCINOMA AND IN BENIGN BREAST PARENCHYMA. - LYMPHOVASCULAR INVASION IS PRESENT.S PERINEURAL INVASION IS PRESENT.S - NO INVOLVEMENT OF THE SURGICAL MARGINS BY BITHER INVASIVE OR IN SITUS CARCINOMA IS IDENTIFIED. PATH REPORT ** Continued on next page ** ICs -0 - 3 carcioma, nfiPtrstny duct, ives 8.5oi/3 Site: breast, Nos C50.9 10/21/
+
+--- Page 2 ---
+NO SKIN INVOLVEMENT BY CARCINOMA IS IDENTIFIED Page' 2of 4 - THE NON-NEOPLASTIC BREAST TISSUE SHOWS STROMAL FIBROSIS AND FLORID DUCTAL HYPERDLASIA. THE'LYMPH NODE STATUS IS AS FOLLOWS (EXPRESSED AS THE NUMBER OF POSITIVE LYMPH NODES INS RELATION TO THE TOTAL NUMBER OF LYMPH NODES EXAMINED): LEVEL I: O/15. - IMMUNOHISTOCHEMCIAL STUDIES FOR ESTROGEN AND PROGESTERONE RECEPTORSS (RR/PR) ARE POSITIVE. IMMUNOHISTOCHEMISTRY FOR HER2/NEU (HERCEPTEST) IS BEING REPEATED AND WILL BE REPORTED INS AN ADDENDUM. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHKR MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. *** Report Electronically Signed Out * Special Studies: Result Special Stain. Comment CAm 5.2 CAM 5.2 AE1:AE3 AE1:AE3 NEG CONT IMM RECUT NEG CONT IMM RECUT CAM 5.2 AE1:AE3 NEG CONT IMM RECUT eR-C pR-C hER2-C NEG CONT NEG-HER2 IMM RECUT Gross Description: 1) The specimen is received fresh for frozen section, labeled nSentinel node #1, level 1, rt. axilla". It consists of single lymph node measuring 2.5 x 0.5 x 0.3 cm. Entirely frozen. Sumunary of Sections: FSCA and B  - frozen section control A and B  PATH REPORT * Continued on next page **
+
+--- Page 3 ---
+2) The specimen is received fresh for frozen section, labeled "Sentinel node #2, level 1, rt. axilla". It consists of of single lymph node. measuring 2.5 x 0.5 x 0.3 cm. Entirely frozen. Summary of Sections: FSCA and B - frozen section control A and B 3) The specimen is received fresh, labeled, "Rt. breast (stitch marks level one lymph nodes)". It consists of a right mastectomy consisting of tan skin, breast tissue and axillary tail designated as level one. The skin present on the skin surface.  No skeletal muscle tissue is present at the. deep margin, which is inked. The breast tissue is sectioned to reveal an. indurated, irregular gray-white tumor, situated in the upper outer quadrant, 4.0 cm from the deep margin and measuring 3.5 x 3.0 x 3.0 cm. the braast tissue is fibrofatty.. The rest of  The axillary tail is sectioned to reveal multiple lymph nodes ranging from 0.8 up to 1.5 cm in greatest dimension. The largest node is bisected. Tumor and normal tissue taken for TPS.. Representative sections are submitted. Sunmary of Sections: N  nipple  tumor DM  deep margin closer to the tumor UOQ - 1 upper outer quadrant lower outer quadrant upper inner quadrant LIQ - lower inner quadrant LNI lymph nodes level one. BLNI  bisected lymph nodes level one. Surmary of Sections: Part 1: SP: Sentinel node #1, level 1, rt. axilla (fs) Block Sect. site pCs 1 FSCA ! FSCB Part 2: SP: Sentinel node #2, level 1, rt. axilla (fs) Block Sect. Site PCs Fsc 1 Part 3: SP: Rt. breast PATH * Continued on next page *. REPORT .w..w
+
+--- Page 4 ---
+Block Sect. Site pCs BLN1 DM LIQ 3 2 3 LN1 15 LOQ T 2 UIQ 2 UOQ Procedures/Addenda: Addendum Date Ordered: Status: Date Complete: Signed Out By: Date Reported: Addendum Diagnosis ADDENDUM 3) BREAST, RIGHT; MASTECTOMY HER2/NEU (HERCEPTEST) : NEGATIVE (STAINING INTENSITY OF 1+). [CONTROL IS SATISFACTORY.] Intraoperative Consultation: Note:  The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS: NEGATIVE FOR CARCINOMA. PERMANENT DIAGNOSIS: SAME 2) FROZEN SECTION DIAGNOSIS:  NEGATIVE FOR CARCINOMA. PERMANENT DIAGNOSIS:  SAME PATH REPORT ** End of Report **
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diff --git a/output/text/77cb09d5-ad40-4de7-b560-9ea9a37e7972.txt b/output/text/77cb09d5-ad40-4de7-b560-9ea9a37e7972.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9ee21bf74900cf560852d5a569a590d7d5cff39e
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID: 80ED829A-262A-486D-B31A-EA015FA8A362  Requesting Doctor's Information: Redacted r A HISTOPATHOLOGY FOR REVIEW T H 0 This case was shown at the endocrine clinicopathological meeting. I agree with L diagnosis of adrenal cortical carcinoma. The carcinoma is the same as. that present in the recurrence from. 0 G Y REPORTING PATHOLOGIST: (Electronic Signature) LeD-o 3 C arcionce, adrenol CorticoJ 8378/3 Site! OAdrtrol Clavd,cor+ex A C74.D N AtO iBo/r3 A T 0 M 1 c A L P A T H 0 L 0
+
+--- Page 2 ---
+Sox/D0 FEMALE Coplus to: Keceived: TISSUE(S) RECEIVED: Left adrenal gland. CLINICAL INFORMATION:S Clinically Cushing's. Left adrenal mass.. MACROSCOPIC DESCRIPTION:A Specimen (labelled *left adrenalectomy*) consists of a 45g. ragged and disrupted piece of firm tan tissua 60~x 35 x 40mm, with a non-intact capsule.  Visible from the external surfaca axe multiple nodular protuberans, in addition to orangish/yellow portions of ?residual adrenal tissue. One of the nodules (included in the total measurement) itself measures 26 x 20 x 15mm and attached by thin membranous tissue only to the bulk of the tissue, and has a homogenous tan cut surface.  The main portion of tissue largely comprises a nodule 35 x 35 x 30mm, which has a compressed rim of adrenal tissue at one edge, and has a remaining multinodular appearance with aream specks but predominantly light tan in colour.. (Representative sections: Al&A2 - almost separate nodule; A3-A9 representative large tumour mass; Al0 - more normal appearing adrenal from one. edge of the lesion with adjacent' fibrofatty tissue). Macro Description by: MICROSCOPIC EXAMINATION: Sections show a nodular and diffuse adrenocortical tumour. Most of the cells are generally lipid depleted and are arranged in nests, trabeculae and sheets.. There is wide variation in the nuclear size and shape but generally it is moderate with focal areas showing severe pleomorphism (Fuhrman grade 2-3). There are Some cells contain pAs positive diastase resistant globules. Extensive numerous mitoses (up to 12/lohpf) but atypical mitoses are rare.  The nodules are separated by thin and thick. areas of necrosis are present.. fibrous bands.. Tumour cells are seen. The tumour has a disrupted fibrous capsula. infiltrating through tha capsule in focal areas. The painted resection margin. There is evidence of. is focally involved by tumour cells (blocks A4 & A8).* sinusoidal permeation and endothelial lined space permeation (blocks A4 & A8). Occasional microscopic foci of infiltration into fatty tissue are seen. Scanty remmant non-neoplastic adrenal tissue is present at the periphery of the tumour. Fage:1 ... Continued Thank you for referring this patient
+
+--- Page 3 ---
+x/DO FEMALE Coples loc Received: IMMUNOCHEMISTRY: The tumour cells are positive for synaptophysin and melan-A. They are negative for AE1/AE3. They give weak focal staining with cDio.. The staining characters are consistent with adrenocortical tumour. COMMENT: Frequent mitoses with occasional atypical mitoses, nuclear pleomorphism, endothelial lined space permeation and necrosis are supportive of the diaanosis of carcinoma.. Dr has also seen this case and agrees with the above. DIAGNOSIS LEFT ADRENAL, MASS: ADRENOCORTICAL CARCINOMA.S (PLEASE SEE COMMENT). r93000, M80103 (Elertranic signature) Case is (circ'e) Thnnk umu fnr rofarrina thie nntion.
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diff --git a/output/text/7809efea-619f-4c30-a966-cb75f2aa9c06.txt b/output/text/7809efea-619f-4c30-a966-cb75f2aa9c06.txt
new file mode 100644
index 0000000000000000000000000000000000000000..911f81eb15562114a4a91a7c5052fce08364668a
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+MEDICAL RECORD Surgica! Pathology Report. Surgical Pathology Report PATIENT: MRN: ACCOUNT#: RECEIVED DATE: DOB: PROCEDURE DATE: AgE: SEX: SIGN-OUT DATE: ATTENDING:S LOCATION: REQUESTING: ROOM: CONTACT NO: (MD) COPIES TO: DIAGNOSIS: Kidney, right (nephrectomy): Renal cell carcinoma, chromophobe type. The tumor does not penetrate the renal capsule. Vascular and ureteral margins are free of tumor. Adrenal gland; no tumor seen.. CLINICAL INFORMATION: HISTORY:INCIDENTAL RIGHT KIDNEY MASS EXAM IS RELATED TO ORDERING PROTOCOL PROCEDURE: PREOP DX:#RIGHT KIDNEY TUMOR POSTOP DX: SAME OPERATIVE FINDINGS: RIGHT KIDNEY WITH MASS SPECIMENS SUBMITTED: KIDNEY, RIGHT GROSS DESCRIPTION The specimen is received fresh in a container labeled "right kidney". It consists of a 495 gram kidney, with an attached adrenal gland. The tumor is processed for procurement provided by UOB. The kidney is opened. prior to arrival to the Surgical Pathology suite to reveal a brown-tan tumor, measuring 7 cm. in maximum. diameter, abutting the renal capsule and located in the superior pole. The perinephric fat around the tumor is inked black avoiding inking the cut tumor. The specimen is serially sectioned and representative sections of the tumor are submitted for permanent. The adrenal gland is also received sectioned prior to arrival in Surgical. Pathology. Two pieces were procured by UOB. The adrenal gland is 6.5 x 2.5 x 0.5 cm. The adrenal gland is serially sectioned to reveal an orange cut surface without gross lesions. Representative sections are submitted for permanent. Patient Identification Surgical Pathology Report Page 1
+
+--- Page 2 ---
+MEDICAL RECORD Surgical Pathology Report The ureteral and vascular margins are identified and are grossly unremarkable and patent. White cassettes submitted: A - ureteral and vascular margins. B - adrenal C through E - tumor, perinephric fat F and G - tumor, kidney parenchyma. H and I - tumor, pelvis J and K - tumor, periphery L - tumor, pelvis M and N - kidney. O - possible hilar lymph nodes. Patient Identification Surgical Pathology Report Page 2
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diff --git a/output/text/7835ee39-07e7-434a-b23b-b8f3123ce529.txt b/output/text/7835ee39-07e7-434a-b23b-b8f3123ce529.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e75dda66ee9e8de8e962537ffa2acfb21738f090
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+
+--- Page 1 ---
+UUID:AD7F09C4-C784-4595-9A0D-901637231E4F Redacted TcDo-3 TCgA-p3-A6T4-01A-PR 8o%3 C$c=Z Sute patt CASE: RECEIVED: Dnersajepeine Jesiono Lip, sal cauy pe^E148 Zej8/9I13 CLINICAL DATA: 4eharynl -year-old man with history of floor of mouth carcinoma (squamous cell carcinoma). GROSS DESCRIPTION: A) Received in formalin designated "left mandibular tumor" is a composite resection specimen that includes an 11 x 8.5 cm ellipse of medium tan, hair-bearing skin with a central 2.5 cm in diameter ulcer and 8.5 cm in diameter region of induration of the skin which extends focally to within 0.3 cm of the anterior cutaneous margin. A smaller, 4 x 0.9 cm ellipse of skin is sutured to the main specimen at the left superior region. Partially embedded in the attached 12 x 8 x 6 cm aggregate of deep soft tissue and skeletal muscle is a portion of the mandible spanning from right anterior premolar region to body of the left mandible. Seven teeth, including a right premolar (with dental restoration), two incisors (one intact, one fractured/decayed), two canine teeth (intact), a portion of the first left premolar (fractured) and a premolar or molar with crown fractured or decayed off at the root: The diagonally transected mandibular cut surfaces appear grossly unremarkable, consisting of cortical and cancellous bone. Left floor of mouth and the attached, approx. 2.5 x 3 cm portion of tongue are largely replaced by an ill-defined, pale tan, firm, exo- and endophytic tumor mass that has eroded through the mid-segment of the included left mandible (bone appears grossly essentially dissolved). Anteriorly, the skin and soft tissue is partially peeled off and sutured back on the mandible (this presumably does not represent a true surgical margin). The medial, right and anterior margin is inked blue and the left lateral, inferior and posterior black. Representative sections are submitted as follows: Al - anterior midline cutaneous margin; A2 - left anterolateral; A3 - left posterior/inferior cutaneous; A4 - right inferior; A5 - right anteroinferior; A6 - right inferolateral; A7 - right superolateral cutaneous, A8 - right anteromedial gingival/tongue (shave margin, taken immediately posterior to transected. right mandible); A9 - tongue and right (medial) margin; A10 - mid-medial margin; All - posterior soft tissue, lateral aspect; Al2 - posterior soft tissue, medial aspect. Bisection of the specimen across the extensively eroded mandible now reveals a 3 cm diameter soft, red-brown, friable cavity and demonstrates that the firm, pale tan tissue grossly consistent with tumor extends essentially to the medial soft tissue margin, grossly. Submitted in A13 - region of destroyed mandible (mid-segment) and closest adjacent margin; A14 and Al5 (decal) - mandible end margins. All margin sections are perpendicular unless stated otherwise.  Received in formalin designated "left neck level II" is a 5 x 4 x 1 cm aggregate of fibroadipose tissue containing multiple lymph nodes of up to 1.5 cm in diameter. The largest node is bisected and submitted in cassette B1, the remaining smaller nodes intact in B2. C) Received in formalin designated "left neck level IIi" is an 8 x 1.5 x. 0.8 cm strand of fibroadipose tissue containing multiple lymph nodes of up to 1.0 cm diameter. All are submitted intact in cassette C1.
+
+--- Page 2 ---
+D) Received in formalin designated "teeth" are three teeth and six fragments of unoriented tooth material. The largest tooth, molar, measures 1.8 x 1 x 0.7 cm and has calculus material attached, and the neck of the tooth has dark brown discoloration. The next largest tooth is a 2.2 x 0.7 x 0.5 cm incisor. Its crown appears to be a restoration of porcelain and silver-colored metal crown. The root is discolored at the junction with the crown. The third is a 2 x 0.5 x 0.4 cm incisor which appears intact. The remaining fragments of dentin, and tan-gray material range up to 0.7 cm in greatest dimension.. FINAL DIAGNOSIS: A) Left mandible, composite resection:. 1.  Squamous cell carcinoma, keratinizing, moderately to poorly differentiated a. Size: est. at least 8 cm. b. Involving floor of mouth, tongue, anterolateral skin (ulcerated) and parotid gland, and penetrating the mandible.. c. Carcinoma present at margin of resection in left inferoposterior and right inferior subcutaneous soft tissue;. - within 0.03 cm of (if not at) the right medial and left posterolateral (parotid region) soft tissue margin,. within 0.1-0.2 cm of medial posterior soft tissue,. - other visualized margins clear by at least 0.3 cm. Decalcification of the mandibular end margins is pending - see subsequent addendum. d. Perineural invasion present.. e. Focally suspicious for angiolymphatic invasion.. 2. Chronic sialadenitis. B) Left level II, neck dissection: Squamous cell carcinoma present in one of 8 lymph nodes (1/8). c) Left level IIl, neck dissection: No carcinoma identified in 6 nodes (0/6). D) "Teeth", extraction: One molar, two incisor teeth, and multiple fragments of tooth material. (Gross evaluation only). COMMENT : The minimum pathologic stage is pT4a, pNl, pMX (AJcc TNM Classification, 6th ed., 2002). ADDendUm CoMmenT: After decalcification, the mandibular margins of the part A specimen (Al4 and Al5, both en-face sections) are examined: Al4 - Right mandibular margin - free of carcinoma.. A15 - Left mandibular margin (posterior-superior) - carcinoma present within bone, soft tissue and perineural space. W 72913 DISaBAC
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diff --git a/output/text/7839321e-a6c4-4481-81aa-69d48c811ca1.txt b/output/text/7839321e-a6c4-4481-81aa-69d48c811ca1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..930ad7049e91da654641542b1021db84d5ec4d9b
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+
+--- Page 1 ---
+Clinical Diagnosis asd History: Multicentric Dcis and invasive cancer of left breast (mass at 12:00 and  DcIs on core biopsy 9:00). Specimens Submitted: 1: Sp: Sentirel node #1, level 1. 3: SP: Sentinel node #2, level i, lest : axilla 3: SP: Sentinel node #3, left  axilla 4: SP: Sentinel node #4, level 1, left axille level Non-sentinel aode. left 1. left axilla 5: SP 6: Sp: Left total mastcctomy ( axilla UUID:AE348902-0573-4A57-BBD6-037FA2AF1872 DIAGNOSIS:S TCGA-A0-A125-01A-PR Redacted 1) LYMPH NODE, SENTINEL #1, LEVEL I, LEFT AXILLA; EXCISION: -ONE 3ENIGN LYMPH NODE (O/1. - DEEPER LEVEL RECUTS AND SPECIAL STAINS HAVE BEEN ORDERED. THE RESULTS WILL BE REPORTED IN AN ADDENDUM. 2 LYMPH NODE, SENTINEL #2. LEVEL I, LEFT AXILLA; EXCISION: ONE BENIGN LYMPH NODE (O/1). - DEEPER LEVEL RECUTS AND SPECIAL STAINS HAVE BEEN ORDERED. THE RESOLTS WILL BE REPORTED IN AN ADDENDUM. 3) LYMPH NODE, SENTINEL #3, LEVEL I, LEFT AXILLA; EXCISION: - ONE BENIGN LYMPH NODE (O/1). - DEEPER LEVEL RECUTS AND SPECIAL STAINS HAVE BEEN ORDERED. THE RESULTS WILL BE REPORTED IN AN ADDENDUM. 4) LYMPH NODE, SENTINEL #4. LEFT AXILLA; EXCISION: - ONE BENIGN LYMPH NODE (O/I). - DEEPER LEVEL RECUTS AND SPECIAL STAINS HAVE BEEN ORDERED. THE RESULTS WILL BE REPORTED IN AN ADDENDUM. 5 LYMPH NODE, NON-SENTINEL, LEFT AXILLA; EXCISION: ONE BENIGN LYMPH NODE (O/1). 6) BREAST, LEFT; TOTAL MASTECTOMY: - IN-SITU AND INVASIVE PAPILLARY CARCINOMA.S - THE TUMOR MEASURES 3 CM IN GREATEST DIMENSION. TUMOR GROWS AS LARGE BROAD FRONTS, IT IS NOT POSSIBLE TO SINCE THE ASSESS THE EXTENT OF INVASICN. - DUCTAL CARCINOMA IN-SITU (DCIS) IS ALSO IDENTIFIED, SOLID/CRIBRIFORM TYPES, WITH INTERMEDIATE NUCLEAR GRADE. - THE INVASIVE CARCINOMA IS LOCATED IN THE CENTRAL/ SUPERIOR PATH - Continued on next page ** REPORT 11 IC s-0-3 CaLCime, papu1arg,1ves(N1ieNc) 805v/3 Sit: hrnst, Nis hw 10fssfu C50.7 J toj*+/
+
+--- Page 2 ---
+AREA. - THE DCIS IS LOCATED IN THE CENTRAL/SUPERIOR AREA AND MEDIAL ASPECT AT THE PREVIOUS BIOPSY' SITE. - NO INVOLVEMENT OF THE NIPPLE BY EITHER IN-SITU OR INVASIVE CARCINOMA IS IDENTIFIED 1 -CALCIFICATIONS ARE PRESENT IN THE IN-SITU CARCINOMA AND IN BENIGN 3REAST PARENCHYMA. - NO VASCULAR INVASION IS NOTED. INVASIVE CARCINOMA IS O.3 CM FROM THE NEAREST (SUPERIOR) MARGIN. - DUCTAL CARCINOMA IN-SITU IS O.3 CH FROK THE NEAREST (SUPERIOR) MARGIN. - NO SKIN INVOLVEMENT BY CARCINOMA IS IDENTIFIED. THE NON-NEOPLASTIC BREAST TISSUE IS UNREMARKABLE. - THE NON-NEOPLASTIC BREAST TISSUE SHOWS BIOPSY SITE CHANGES, FIBROCYSTIC CHANGES. BENIGN PAPILLOMAS AND SCLEROSING ADenOSIS. - RESULTS OF SPECIAL STAINS (ER, PR, HER2-NEU) WILL D3 REPORTED AS AN ADDENDUM. NOTE: DR. BROGI HAS REVIEWED SELECTED SLIDES AND CONCURS.  Report Electronically Signed Out I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL). AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Special Studies: Stain/Procedure Name Result Comment AE1:AE3 NEGATIVE KERATIN (CAM5.2) NEGATIVE CONTROL NEGATIVE IMMUNO RECUT NEGATIVE CONTROL . Canceled IMMUNO RECUT : Canceled AE1:AE3 NEGATIVE KERATIN (CAM5.2) NEGATIVE NEGATIVE CONTROL IMMUNO RECUT NEGATIVE CONTROL IMMUNO RECUT Canceled AE1:AE3 NEGATIVE KERATIN (CAMS.2) NEGATIVE  NEGATIVE CONTROL IMMUNO RECUT NEGATIVE CONTROL : Canceled IMMUNO RECUT  Cancelcd AE1:AE3 NEGATIVE KERATIN (CAMS.2) NEGATIVE PATH REPORT * Continued on next page  11
+
+--- Page 3 ---
+NEGATIVE CONTROL Pagesotb IMMUNO RECUT NEGATIVE CONTROL * Canceled IMMUNO RECUT + Canceled ESTROGEN RECEPTOR POSITIVE M PRCGESTERONE RECEPTOR POSITIVE HER2-C  NEGATIVE INTENSITY O NEGATIVE CONTROL IMMUNO RECUT  SYNAPTOPHYSIN CHROMOGRANIN MIB-1 (Ki-67) RECUT ADDITIONAL HE CALPONIN NEGATIVE CONTROL  Canceled IMMUNO RECUT  Canceled NEGATIVE CONTROL IMMUNO RECUT NEGATIVE CONTROL FOR HER2 Gross Description: 1) The specimen is received fresh for frozen section diagnosis, labeled -Sentinel node #1. level I, left axillar. consists of a lymph node measuring 2 x 1.5 x 0.5 cm. It specimen is submitted in ono cassette.  The eatire Surmary of sections: FSC .' frozen section control 2) The specimen is received fresh for frozen section. diagnosis. labeled "Sentinel aode #2. level I, left axilla". consists of a lymph node measuring 0.7 x 0.7 x 0.4 cm. It entire specimen is submitted in one cassette.. The Sumary of sections: FSC . frozen section control 3) Tha specimen is received fresh for froren section. diagnosis, labeled *Sentinel node #3, level I, left axilla". consists ot a lymph node measuring 2'x 1.5 x 0.7 cm.. It The antire specimen is submitted in one cassette.. Sunmary of sections: FSC - frozea section control PATH REPORT ontinued on next page 11
+
+--- Page 4 ---
+4} The specimen is received fresh for frozen section diagnosis, iabeled -Sentinel node #4. level I, left axilla". consists of a lymph node measuring 2.5 x 0.6 x 0.5 cm. entire specimen is submitted in one cassette. The Summary of sections: FSC - frozen section control. 4 5) The specimen is received fresh for frozen section diagnosis, labeled -Non-sentinel rode. left axilla'. It consists of a lymph node measuring 2.5 x 1.5 x 0.6 cm. The entire specimen is submitted in one cassette.. Summary of sections: ESC - frozen section control. 6) The specimen is received fresh, labeled -Left Total Mastectomy, Stitch Marks Axillary Aspect". a total mastectony measuring 20. 0 x 15.0 x 6.0 cm. The skin is It consists of brown-black and measures 17.0 x 7.0 cm. Arcola nipple complex is unrenarkabie and mcasures 3.5 cm ic diameter. grossly identified. No scars were  The cut sections reveals a mass measuring 3.0 x 2.5 x 2.0 cm. This mass is located 0.5 cm from the through the other areas of the breast shows fibrocystic changes. The cut sections Sections from the lateral upper and lower, medial upper and iower quadrants are at least 1.o cm from the closest deep margin. tunor is submitted entirely. The also submitted. Surmary os Sections: N - ripple TSM - tumor superior margin. t . tumor LL - - lateral lower quadrant LO - lateral upper quadrant ML -  medial lower quadrant skin Sunmary of Sections: Part Sect. Sito Blocks Pioces A11 1 rsC 2 Fsc H m H 3 psc t 1 m r 2 m 2 2 rsc Fsc H E LL LU E x ML MU M PATH ** Continued on next page **. REPORT 11
+
+--- Page 5 ---
+Page 5 of 6 N SK H m N r TSM M Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS: BENIGN. PERMANENT DIAGNOSIS:  SAME . 2) FROZEN SECTION DIAGNOSIS:  BENIGN. PERMANENT DIAGNOSIS:  SAME. 3) FROZEN SECTION DIAGNOSIS: BENIGN. PERMANENT DIAGNOSIS: SAME. $ FROZEN SECTION DIAGNOSIS: BENIGN. PERMANENT DIAGNOSIS:  SAME . 5) FROZEN SECTION DIAGNOSIS: BENIGN. PERMANENT DIAGNOSIS:  Same. ADDENDUM: ** SIGNED CUT ADDENDUM REPORTS SITE: LEFT BREAST, #6 ER-ICA:  POSITIVE PR-ICA: POSITIVE HER2/NEU (HeXCep TeSt) : NEGATIVE (SIAINING INTENSITY 0) CONTROLS ARE SATISFACTORY. Report Electronically Signed Out ADDENDUM: ** SIGNED OUT ADDENDUM REPORT PATH REPORT Continued on next page ** 11
+
+--- Page 6 ---
+SITE:  SENTINEL LYMPH NODES, LEFT AXILLA PARTS #1, 2, 3. 4 ADDITIONAL HE STAINED SECTIONS AND IMMUNOHISTOCHEMICAL STAINS FOR CYTOKERATINS (AE1:AE3 AND CAMS.2) SHOW NO EVIDENCE OF METASTATIC TUMOR.  Report Electronically Signed Out PATH REPORT End of Repo 11
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diff --git a/output/text/7860fdb5-f4ab-4d9f-824b-711f56d00ddd.txt b/output/text/7860fdb5-f4ab-4d9f-824b-711f56d00ddd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..01b22fb306f9891f09a02e8dd37a2b4d26870658
--- /dev/null
+++ b/output/text/7860fdb5-f4ab-4d9f-824b-711f56d00ddd.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis: Right hemicolectomy preparation with ulcerated colon carcinoma of the histological type of a moderately differentiated colorectal adenocarcinoma, located in the area of the passage between the cecum and ascending colon, encircling the intestinal wall and measuring. 4.5 cm in length. Invasive spreading of the tumor within all intestinal wall layers to the. bordering mesocolic adipose tissue. Appendix with fibrous obliteration of the lumen. Tumor-free oral and aboral resection margin as well as greater omentum. Fifty lymph. nodes in the region tumor-free with uncharacteristically reactive changes. Tumor stage therefore pT3 pN0 (0/50) LO0 V0: G2 R0.
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diff --git a/output/text/78bf16eb-8c80-4d38-94c2-2448cfd23654.txt b/output/text/78bf16eb-8c80-4d38-94c2-2448cfd23654.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f0f207db76e6e40bce28cb6c01b90af1a9b46761
--- /dev/null
+++ b/output/text/78bf16eb-8c80-4d38-94c2-2448cfd23654.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+TCGA- B3-- 4104 SPECIMEN Right kidney, right ureter, bladder cuff CLINICAL NOTES PRE-OP DIAGNOSIS: Right renal mass GROSS DESCRIPTION Received fresh for tissue procurement labeled "right kidney, ureter and bladder cuff" is a 513 gram, 11.5 x 7.0 x 4.0 cm. right kidney with attached, probe patent, 20 cm. ureter measuring up to 0.8 cm. in diameter with a scant amount of apparent bladder wall at the distal end (see distal margin block 1). A moderate amount of perirenal adipose tissue is present. No adrenal gland is identified superiorly. The renal capsule is delicate and strips with relative ease from the underlying cortical surface. On opening, the pelvis is dilated, granular tan pink-red and contains a superiorly located, 4.0 x 3.5 cm. papillary white pink lesion. A portion of tumor and a portion of normal parenchyma are submitted for tissue procurement as requested. On sectioning, the tumor has a maximal thickness of 2 cm. and is within 0.9 cm. of the anterior inked capsular surface. No vascular invasion is identified grossly. The parenchyma is uniform red-brown with multiple cortical cysts, a well-defined corticomedullary junction and a maximal cortical thickness of 1.3 cm. The ureter is received with a stent in place and on opening the mucosa ranges from smooth and unremarkable white pink to slightly bosselated tan pink-red. No discrete mass lesion is identified. Representative sections are submitted in 15 blocks as labeled. Rs-15.. BLOcK suMMARy: 1 - Vascular and uretera1 margins; 2-5 - renal pelvis tumor including inked capsular surface; 6, 7 - additional sections of tumor to adjacent parenchyma; 8, 9 - random pelvis; 10-12 - random parenchyma including cortical cysts; 13  - proximal ureter; 14 - mid ureter; 15 - distal ureter.
+
+--- Page 2 ---
+GROSS DESCRIPTION MICROSCOPIC DESCRIPTION Histologic type: Papillary urothelial cell carcinoma Histologic grade: High grade. Associated epithelial lesions:. Primary tumor (pT): Tumor has invaded through the muscularis propria of the renal pelvis (pT2).. Margins of resection: . Distal ureteral margin of resection free of tumor. Regional lymph nodes (pN): Cannot be assessed (pNx). Distant metastasis (pm): Cannot be assessed (pmx). Vascular invasion:. Negative. Other findings: Benign cortical cysts. Arteriolar nephrosclerosis. 4 DIAGNOSIS Kidney, right nephroureterectomy:. High grade papillary urothelial cell carcinoma of the renal pelvis extending through the muscularis propria of the pelvis. Distal ureteral margin of resection is free of tumor. Associated carcinoma in situ.. Benign cortical cysts.. Arteriolar nephrosclerosis. --- End Of Report ---
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diff --git a/output/text/78e5a967-9479-4fca-8559-aee5730a288c.txt b/output/text/78e5a967-9479-4fca-8559-aee5730a288c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ecad3cef5b5c0cdfc9eb679f3cac0200a3768f69
--- /dev/null
+++ b/output/text/78e5a967-9479-4fca-8559-aee5730a288c.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID: FA1D30C7-E486-48DD-989F-E774B42EA1B1 IcD-o-3 TCgA-2F-A9K0-01A-pr Redacted arcunomos, wrstreQiol NoS 8lq0|3 Pathology report min C4Z4 Blodser, overeoppire Jeoin S78 Date of tumor procurement. AO i/z9/i4 Date of report Histologic diagnosis. High grade muscle invasive urothelial cell carcinoma + CiS. T3aN0Mx Anatomic site and laterality. Right dorsolateral bladder wall. Tumor size 2.5cm diameter Lymph node status. A total of 18 lymph nodes all without tumor localization W 1x/10f13
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diff --git a/output/text/78ef7b13-f809-4717-b05b-fec8336edea2.txt b/output/text/78ef7b13-f809-4717-b05b-fec8336edea2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4af2dffc1d992c7e341ab564594b749a3774a9af
--- /dev/null
+++ b/output/text/78ef7b13-f809-4717-b05b-fec8336edea2.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:15FE46F1-194A-4799-8C77-A3FA23CC5096 Redacted TSS Patient ID: Surgical Date: Gross Description: Received is 1 specimen with pancreatic and duodenal tissue. with severa! sutures present. The duodenum measures 19 cm in length x 3.2. cm in diameter. The serosal surface is smooth, glistening, tan-pink with cautery artifact. The duodenum is opened longitudinally to reveal tan-brown mucosa with an ampulla that is 5 cm from the proximal margin, and. is surrounded by a 1.7 x 1 cm red-tan ulcerative lesion.. The pancreas measures 7.5 x 6 x 4.5 cm, and the neck margin is removed en. face and submitted for frozen section diagnosis. The pancreas is sectioned to reveal that the major pancreatic duct is obstructed approximately 1.5 cm from the neck margin. There is an ill-defined, indurated, white-yellow lesion that is 2 x 2.5 x 2.3 cm. The mass possibly invades the common bile duct, which is friable and hemorrhagic, and dilated to 1.2 cm in diameter. The common bile duct is patent through the ampulla. The mass is 1 cm to the neck margin, 0.8 cm to ED-o-3 HS 5/1c/14 the long blue (portal vein), 2.8 cm to the long black (SMA), 0.6 to looped black (deep radial), 0.1 cm to nearest radial margin, and 6 cm to the proximal duodenal margin. ** Microscopic Description: FNos Diagnosis Details: - Pancreatic ductal adenocarcinoma, moderately differentiated 4.25.0 - AJCC pathologic stage (7th edition): pT3 pN1, stage IIB Pancreas (Exocrine) Cancer Synopsis Specimens Involved Specimens:. A: Common bile duct FS B: Metal stent (for identification only) C: Gastroduodenal artery lymph node
+
+--- Page 2 ---
+D: Whipple FSx2 Specimen: Head of pancreas, Duodenum, Common bile duct Procedure: Pancreaticoduodenectomy (Whipple resection), partial pancreatectomy Tumor Site: Pancreatic head. Tumor size greatest dimension: 2.5cm. Histologic Type: Ductal adenocarcinoma Histologic Grade (ductal carcinoma only): G2 Microscopic Tumor Extension: Tumor invades peripancreatic soft tissues AJCC Stage (7th Edition) (pTNM) Primary Tumor (pT): pT3 Regional Lymph Nodes (pN): pN1 Number of regional lymph nodes involved: 1 Number of regional lymph nodes examined: 23 Distant Metastasis (pM): Not applicable. Margins: Negative for invasive carcinoma Distance of invasive carcinoma from closest margin: 0.1cm Closest margin: radial Treatment Effect: No prior treatment. Angiolymphatic Invasion: Absent Perineural Invasion: Present. Comments:a Formatted Path Reports: PANCREAS TiSSUE CHECKLIST Specimen type: Whipple resection Tumor site: Head. Tumor size: 2.5 cm
+
+--- Page 3 ---
+Histologic type: Adenocarcinoma, ductal type Histologic grade: Moderately differentiated Tumor extent: Other - Peripancreatic soft tissues Lymph nodes: 1/23 positive for metastasis (Regional 1/23) Lymphatic invasion: Absent. Venous invasion: Absent. Margins: Uninvolved Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None fw 1|18|44
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diff --git a/output/text/793d2e26-3e80-4590-a833-a0020de3e6eb.txt b/output/text/793d2e26-3e80-4590-a833-a0020de3e6eb.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2a060a0759a01d75cdd62ed03567edbb766858b0
--- /dev/null
+++ b/output/text/793d2e26-3e80-4590-a833-a0020de3e6eb.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+JCD-0-3 Carciomn,mfilfnahirg ductal, vos8sosf3 Sit: Duot, UoQ C50.4 CQCF Site: Busst, Nos c5o.9 On the basis of these findings, the following overall diagnosis is established:.  Left breast segment at 2 o'clock with a 3.5 cm invasive ductal breast carcinoma grade 3 (3/3/2) with minimum distance of 1 mm from dorsal resection margin and cranial resection margin of 3 mm with very small components of ductal carcinoma in situ grade 3 with comedo necrosis, as well as a lymph node with a tumor (1/11). Tumor classification: pT2 (3.5 cm), pN1 (1/11), MX grade 3 (L0/V0), R0 (dorsal 1 mm, cranial 3 mm). Redacted
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diff --git a/output/text/795cfeb7-4b33-467c-82b1-d897d2875734.txt b/output/text/795cfeb7-4b33-467c-82b1-d897d2875734.txt
new file mode 100644
index 0000000000000000000000000000000000000000..96595cabcd5de01efc001c5a212b3c5ea10f2b7a
--- /dev/null
+++ b/output/text/795cfeb7-4b33-467c-82b1-d897d2875734.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Findings and diagnosis relating to the problem The material at hand is an invasive adenocarcinoma of the colon in block A, poorly differentiated, tending toward partial neuroendocrine differentiation, with penetration of all wall layers and clear vascular infiltration (corresponding to p T 3, L1, V1). Otherwise, in relation to the mucosa resection margins: orally - mucosa of ileum type and  distally - mucosa of colon type  in relation to the ligature region -- local fatty connective tissue with proper vascular  sections relating to the appendix - chronic recurrent, partially scarring appendicitis with clear activation of the lymph follicle, and  relating to the lymph nodes - chronic resorptive lymphadenitis, also with clear  activation of the lymph follicle Tumor classification: ICDO-DA M 8140/3 G 3 p T 3, L1, V1, p N O consistent with R 0. N (0/12)
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diff --git a/output/text/797a299c-eb00-450c-ae03-e2b9f5d7ac37.txt b/output/text/797a299c-eb00-450c-ae03-e2b9f5d7ac37.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fdc080c543091d030f761e65a2bdc994ab09dbfa
--- /dev/null
+++ b/output/text/797a299c-eb00-450c-ae03-e2b9f5d7ac37.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+Other Related Data: Billing Type: Financial Number: Clinical Diagnosis & History: Left renal mass. Specimens Submitted: 1: SP: Left kidney and adrenal gland 2: SP: Superhilar periaortic lymph node  3: SP: Para-aortic lymph node DIAGNOSIS: 1) KIDNEY, LEFT; RADICAL NEPHRECTOMY: RENAL CELL CARCINOMA, CLEAR CELL TYPE, NUCLEAR GRADE II/IV. THE PATTERN OF GROWTH IS ACINAR.  THE TUMOR GREATEST DIAMETER IS 12.O CM. THE TUMOR EXTENDS THROUGH THE RENAL CAPSULE BUT IS CONFINED WITHIN GEROTA'S FASCIA, NO INVASION OF THE RENAL VEIN IS IDENTIFIED. ALL SURGICAL MARGINS ARE FREE OF TUMOR. THE NON-NEOPLASTIC KIONEY SHOWS A SINGLE CYST, 2.O CM IN GREATEST DIMENSION. THE ADRENAL GLAND IS UNREMARKABLE. 2) LYMPH NODE, SUPERHILAR PERIAORTIC; EXCISION: - THREE LYMPH NODES, NEGATIVE FOR TUMOR (O/3). 3) LYMPH NODE, PARA-AORTIC; EXCISION: TEN LYMPH NODES, NEGATIVE FOR TUMOR (O/1O) (SEE NOTE). NOTE: SOME OF THE LYMPH NODES SHOW GRANULOMATOUS LYMPHADENITIS FEW OF THE GRANULOMAS SHOW NECROSIS. SPECIAL STAINS FOR MICROORGANISMS WILL BE REPORTED AS AN ADDENDUM. A BENIGN VASCULAR LESION IS IDENTIFIED IN THE PERIRENAL ADIPOSE TISSUE. IMMUNOHISTOCHEMICAL EVALUATION TO FOLLOW. Page 1 of 4
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT Gross Description: 1) The specimen is received fresh for frozen section, labeled, #Left Kidney and Adrenal Gland". It consists of a product of a left radical nephrectomy weighing 1, 050 grams and measures 17.0 cm from superior to inferior, 14.0 cm from medial to lateral and. 8.0 cm from anterior to posterior. The periadrenal adipose. tissue in the superior aspect is serially sectioned to reveal a adrenal gland which measures approximately 3.5 x 2.0 x 1.5 cm. Serial sectioning reveals unremarkable, cut surfaces. Approximately, 3.0 cm medial to the adrenal gland is a perirenal. lymph node which measures 1.5 x 1.0 x 1.0 cm. The renal vein is patent, the attached segment of ureter measures approximately 10.0 cm and is patent throughout. The ureter is opened and unremarkable. Serial sectioning reveals the mass measures 12.0 x 11.5 x 8.0 cm. Cut surfaces are yellow-orange and focally hemorrhagic. Focal area of tan-white, fibrous regions are identified. In the superior pole is a simple renal cyst which measures 2.0 cm in greatest dimension. It occupies approximately 80% of the kidney.  The fibrous component represent approximately 20% of the tumor. Sunmary of Sections: Fsc - frozen secti.on control A - adrenal. IN - 1ymph node UM - ureteral margin VM - vascular margin R - representative section C - cyst r - tumor 2) The specimen is received in formalin, labeled, "Super Hilar peri-aorti.c lymph node". It consists of multiple lymph nodes. measuriny 6.0 x 3.0 x 2.0 cm. Multiple possible lymph nodes are identified. Summary of Sections: IN -- lymph node LNB - lymph node bisected 3) The specimen is received in formalin, labeled "para-aortic Lymph node". It consists of an aggregate of lobulated adipose tissue and possible lymph nodes which measure 6.0 x 3.0 x 3.0 cm. Multiple possible lymph nodes are identified. Summary of Sections: L - lymph nodes intact LB - lymph node bisected Histo Stain Results/Comments: Stain/Procedure Name Result Comment Page 2 of 4
+
+--- Page 3 ---
+SURGICAL. PATHOLOGY REPORT MEIANOMA-E (HMB-45) NEGATIVE SMOOTH MUSCLE ACTIN POSITIVE CD31 POSITIVE  NEGATIVE CONTROL IMMUNO RECUTS AFB PAS-D METH Ag(GMS) AFB PAS-D METH Ag(GMS) Summary of Sections: Part Sect. SiteBlocks Pieces All A 1 2 N c 1 2 FSC 1 1 LN 2 4 R 1 1 7 M Um 1 1 VM 1 2 2 LB 4 M N 3 L 2 M N SPECIAL STAINS FOR MICRO-ORGANISMS INCLUDING GMS, AEB AND PAS-D, PERFORMED ON THE NECROTIZING GRANULOMAS, ARE NEGATIVE. THE BENIGN VASCULAR LESION IDENTIFIED ON THE PERINEPHRIC ADIPOSE TISSUE WAS STAINED WITH CD31, SMA AND HMB-45.  THE LESION IS CD31 AND SMA POSITIVE AND HMB-45 NEGATIVE INDICATING THAT IT IS AN HEMANGIOMA. Page 3 of 4
+
+--- Page 4 ---
+SURGICAL PATHOLOGY REPORT Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS: RENAL CORTICAL NEOPLASM. FAVOR CARCINOMA. PERMANENT DIAGNOSIS: SAME. Page 4 of 4 END OF REPORT
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diff --git a/output/text/797e7a8d-5ed5-4ebc-aac5-5b93efaf77a4.txt b/output/text/797e7a8d-5ed5-4ebc-aac5-5b93efaf77a4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..999a3728a65d0631fcda2365706e9857417eb52c
--- /dev/null
+++ b/output/text/797e7a8d-5ed5-4ebc-aac5-5b93efaf77a4.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+IcD6-3 Caensnianenal cIl SURGICAL PATHOLOGY Chrsmsphobe tyjee 8317|3 Case Number : Sut OfidnyNOS C649 Diagnosis: 9tJ 8/qf 3 A: Kidney, left, laparoscopic nephrectomy Tumor histologic type/subtype: Renal cell carcinoma, chromophobe type Sarcomatoid features: not identified Histologic grade: 2 (of 4, Fuhrman classification) Tumor size: 5.5 cm diameter Tumor focality: unifocal Extent of invasion: Extra-capsular invasion into perirenal adipose tissue: not involved Renal sinus: not involved. Major veins: not involved. Ureter: not involved Venous: not involved Lymphatic: not involved. Surgical margins: Perinephric adipose tissue margin: negative Renal vein: negative Ureter: negative JUID:933DE352-E2B3-4C8C-9828-EF549B971814 Adrenal gland: not received TCGA-UW-A72S-01A-PR Reda acted Lymph nodes: not received AJcc Stage (kidney): pTlb pNx pMx This staging information is based on information available at the time of this report, and is subject to change pending clinical review and additional information. Clinical History:. -year-old female with renal neoplasm. Gross Description: Specimen A:
+
+--- Page 2 ---
+Specimen fixation: Fresh, and later placed in formalin Type of specimen: Left laparoscopic nephrectomy. Side of specimen: Left Size and weight of specimen: Weight 425 gram, 16.0 x 8.5 x 5.5 cm Orientation: The perinephric fat is inked blue. Presence/absence of adrenal gland: Absent Tumor site: Renal cortex, mid pole Tumor description: The tumor is tan/pink, soft with punctate. hemorrhage and a 1.5 x 1.4 cm central area, which is yellow soft and liquified. The tumor appears well-circumscribed, with an. area suspicious for extracapsular extension. Tumor size: 5.5 x 4.7 x 4.2 cm Presence/absence of multicentricity: Absent Confinement/non-confinement to the kidney: A foci where the mass appears to extend through the renal capsule. Extent of invasion:. Perirenal adipose tissue: May involve Gerota' s fascia: Does not involve Renal vein: Does not involve Ureter: Does not involve Renal Sinus: Does not involve Pelvicaliceal: Does not involve Adrenal: N/A. Other organs: N.A. Surgical margins:.
+
+--- Page 3 ---
+Perirenal adipose tissue: Negative Renal vein: Negative Renal artery: Negative. Ureter: Negative. Description of kidney away from tumor: Within the inferior pole'. there is a 0.4 cm in greatest dimension smooth walled cyst. The remainder of the kidney parenchyma is tan/red with a distinct cortical medullary junction. Hilar lymph nodes: None Other significant findings: Tissue submitted for Yes, tumor and normal is submitted to Digital picture: No. Block Summary: Al - Ureteral vein and artery margins, en face. A2-A3 - Mass with respect to capsule and perinephric fat,. perpendicular A4 - Mass with respect to sinus fat A5 - Mass with respect to capsule and perinephric fat. A6 - Uninvolved kidney parenchyma to include cyst. Tissue remains in formalin. Light Microscopy: Light microscopic examination is performed by Dr. Sections of the renal neoplasm show a discrete encapsulated. population of dyscohesive cells with perinuclear cytoplasmic clearing and prominent plasma membranes. Zones of fat necrosis are noted. By H & E alone, the differential diagnosis includes chromophobe carcinoma and granular cell/conventional renal cell carcinoma, less likely oncocytoma. Immunostains were performed to clarify lineage, and show diffuse reactivity for cK7 and colloidal iron, subset reactivity for Rcc and c-Kit, and. no reactivity for vimentin. This immunophenotype supports. chromophobe carcinoma, makes conventional Rcc unlikely,. and excludes oncocytoma. Dr. concurs.. hw 7f30f13.|
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diff --git a/output/text/79958550-8d76-44aa-a8b2-59d2f7a20c98.txt b/output/text/79958550-8d76-44aa-a8b2-59d2f7a20c98.txt
new file mode 100644
index 0000000000000000000000000000000000000000..98d2908b240e243a49de962851b5bdc9306c423d
--- /dev/null
+++ b/output/text/79958550-8d76-44aa-a8b2-59d2f7a20c98.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Clinical Diagnosis & History: 13.6 cm left renal mass.Radical nephrectomy specimen. Specimens Submitted: 1:SP:Kidney,adrenal gland and enbloc lymph node dissection, left, radical nephrectomy 2:SPLymph node,para-aortic,excision DIAGNOSIS: SP:Kidney, adrenal gland and enbloc lymph node dissection, left, radical nephrectomy Tumor Type: Renal cell carcinoma-Chromophobe type Fuhrman Nuclear Grade: N/A Tumor Size: Greatest diameter is 13.0 cm. The tumor is associated with extensive necrosis Local Invasion (for renal cortical types) Extends through renal capsule but confined within Gerota's fascia Involves renal sinus fat Renal Vein Invasion: Not identified Vascular invasion of small to medium sized vessels is present Surgical Margins: Free of tumor Unremarkable ureter Non-Neoplastic Kidney: Unremarkable Adrenal Gland: Not involved The tumor approaches but does not invade the adrenal gland Lymph Nodes: Not identified Staging for renal cell carcinoma/oncocytoma: pT3a Tumor invades the adrenal gland or perinephric tissues but not beyond Gerota's fascia Page 1 of3
+
+--- Page 2 ---
+SURGICAL PATHOLOGYREPORT SP:Lymph node,para-aortic, excision 2 Lymph Nodes: Not involved Number of nodes examined:8 IATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL).AND THAT I HAVE REVIEWEDANDAPPROVED THIS REPORT. Gross Description: 1) The specimen is received fresh,labeled Left kidney,adrenal gland and en bloc lymph node dissection".It consists of a radical nephrectomy specimen composed of kidney and perirenal fat measuring 30.0 x 12.0 x 10.0 cm and weighing 2252gm. After bivalving the specimena kidney measuring21.0 x 11.0 x 8.8 cm reveals at the upper pole a 13.0 x 12.0 x 10.0 cm partially necrotic yellow-tan centrally scarred tumor. The tumor appears to be well-encapsulated but pushes into the perirenal fat.Gross no evidence of capsule breakthrough is noted.Tumor appears to also deform and abut the calyceal pelvic system with no breakthrough. Serial sectioning of the tumor reveals a hemorrhagic multiple variegated yellow-tan and red tumor with a central area of scarring. Sectioning through the hilar fat reveals multiple lymph nodes. A 14.3 x0.5 cm attachedureter is identified which probe patent and negative for lesions.The ureteral margin is shaved and submitted together with the vacular margins which appear also grossly negative. Sectioning through the perirenal fat reveals a 3.8 x 2.8 x 1.2 cm adrenal gland which abuts the superior surface of the tumor.The tumor appears not to invade the adrenal gland. Gross photographs are taken and TPSis taken. Summary of Sections: MAR-vascular and ureteral margins LN-lymph nodes of renal hilum TNCP-tumor with renal capsule TMSIN-tumor with renal sinus TM-tumor TMPL-tumor and pelvis ADR-adrenalgland with tumor abutting NK-normal kidney TMKI-tumor with adjacent normal kidney 2).The specimen is received in formalin labeled, Paraaortic lymph node"and consists of five possible lymph nodes measuring 4.5 x3 x 1.6 cm in aggregate.Lymph nodes are entirelysubmitted Summary of sections: TLN-trisected lymph node BLN-bisected lymph node LN-whole lymph nodes Summary of Sections Part 1: SP:Kidney,adrenal gland and enbloc lymph node dissection, left,radical nephrectomy (tl) Block Sect.Site PCs 4 adr 4 8 In 8 Page 2 of3
+
+--- Page 3 ---
+SURGICAL PATHOLOGY REPORT 1 mar 1 2 nk 2 6 tm 6 8 tmcap 8 1 tmki 1 1 tmpel 1 3 tmsin 3 Part 2:SPLymph node,para-aorticexcision Block Sect.Site PCs 2 bln 2 3 IIn 3 1 In 1 Page 3of3 ENDOF REPORT
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diff --git a/output/text/7a1895a5-068e-4738-a666-a15bf98f026c.txt b/output/text/7a1895a5-068e-4738-a666-a15bf98f026c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b9b9b39e6cedfaa5a2d0e88f28983d9bf65f5dc8
--- /dev/null
+++ b/output/text/7a1895a5-068e-4738-a666-a15bf98f026c.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Patient Name:. Accession #: Med. Rec. #: Date of Procedure: 008: Date of Receint: Gender: Date of Report: Ref. Physician: Account If: Patient Address: Billing Type. Additional Copy to: Ret. Source is & History: ith incidental leit renal mass discovered on CT Specimens Submitted: 1 Kidnoy. lelt mass, partial nephrectomy 2: Kidney, left. completion nephrectomy. 3: Perinephric fat, lefl, excision DIAGNOSIS: Kidney, left mass, partial nephrectomy: Tumor Type:  Ronal call carcinoma - Unclassiied type The tunor has oncocylic. tubular and papillary leatures Tumor Size: Greatest diameter is 3.8 cn. Local Invasion (for renal cortical typos): Not Identified Ronal Vein Invasion: Nol identilied Surgical Margins: Free of tumor Non-Neoplastic: Kidnoy Unremarkable Adrenal Gland: Not identified Lymph Nodes: Nol identilied Staging for renal coll carcinoma/oncoxytoma: pT1 Tumor <= 7.0 cm in grealest dinension limited to the kidney Comment: Immunohistochemical slains show the tumor cells to be strongly positive for E-cadherin and CD117. positive for Ca-9 and racemase and negative for CK7. 2.Kidney, lelt, completion nephrectomy -No rosidual carcinoma is identified. -Unremarkable renal parenchyma -Incidental medulary libroma (0.2cm)is idenlified Page 1 of 3
+
+--- Page 2 ---
+-Unremarkable urothelium -Unremarkable renal vessols. 3 Porinephric fal. toft, excision:. -Benign fibroadipose tissue. HATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATON OF THE SLIDES ANDIOR OIHER MATERIAL), AND IHAT I HAVE REVIEWED AND APPROVED THIS REPORI Special Studies: Result Special Stain Comment CK7 CA-1X. RACEMASE E-CADHERIN CD117 NEG CONT IMM RECUT Gross Description:. 1).The specinen is received fresh for. mrenal mass.It consists of a 6.0 x 5.0 x 2.8 cm wedge shaped  portion of kidney wih a suture marking the deop margin. The margin is inked black and the specimen is serially seclioned lo. reveal a 3.8 x 3.5 x 3.0 cm. The clearance from the reseclion margin is 0.1 cm. A representalive section of the nearest margin is. subniltod for frozen section diagnosis. Representatively submilted. Portions of the tumor are submilted for TPS. Summary of sections. FSC - trozen seclion control. T-tumor RS - representative sections. 2). The specimen is recoived fresh. laboled leff kidney" and consists of a kidnoy with altached ureter. renal vessols and. perinephric fat weighing 162 g in total.. The kidney measures 12.0 x 5.5 x 3,4 cm.  The attached ureter measures 8.0 cm in length. and 0.2 cm in diameler. The attached renal vein measures 1.5 cm in length and 0.8 cm in diameter. The renal vessels and. ureter margins are grossly unremarkable. An adrenal gland is not identified. There is a central surgical defect in the kidney. measuring 7.5 x 5.0 x 2.5 cm.The kidney is bivalvod to reveal a 0.2 x 0.2 x 0.2 cm well dofinod gray-white firm focus localod in the medulla in lhe upper pole.  The remaining kidney shows pink-brown parenchyma, with a well-defined corlico-medullary junction. The cortex measures 0.5 cm and the calyces appear normal.  There are no other lesions identified. There are no Iymph nodos are identified in the porinephric lat. Representative seclions are subnitled. Summary ol sections. UVM -- ureteral and vessel margins F - 0.2 cm focus D--surgical delect  RP -- renal pelvis representative seclions K -- reprosentalive seclions kidney 3}. The specinen is received fresh. labeled "peri-nephric fat. lelt" and consisis of mulliple piocos of adipose tissue measuring 12.0 x 10.5 x 3.5 cm in aggregate. No tumor or lymph nodes identified. Representative sections are submitted. Summary of sections: Page 2 of 3
+
+--- Page 3 ---
+F-- adipose tissue Summary of Sections: Part 1: Kidney, left mass, partial nophrectomy Block Sect. Site PCs 1 1 2 rs 2 4 4  Part 2: Kidney, left, completion nephrectomy Block Sect. Site pCs 3 d 3 1 1 k 1 1 ip 1 1 uvm 1 Part 3: Perinephric fat, left, exclsion Block PCs Sect. Site 1 f 1 Intraoperative Consultation: Nole:  The diagnoses given in this section portain only to the lissue sampte examined at the time of the intraoperative consulation. 1) FROZEN SECTION DIAGNOSIS: SP: LEFT RENA! ONCOCYTIC RENAL CORTICAL NEOPLASM. MARGIN IS CLOSE, BUT NEGATIV PERMANENT DIAGNOSIS:same Page 3 of 3 END OF REPORT
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diff --git a/output/text/7a2b1ff8-ed98-41eb-a389-7a2fb6225068.txt b/output/text/7a2b1ff8-ed98-41eb-a389-7a2fb6225068.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7270e1fe265fa2e50141759a23e4c002a13ca628
--- /dev/null
+++ b/output/text/7a2b1ff8-ed98-41eb-a389-7a2fb6225068.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+DIAGNOSIS: 1.  Adrenal gland, left, mass, adrenalectomy (1FS): Adrenal adenoma. 2. Kidney, left, tumor #1, resection: Renal cell carcinoma, papillary type I. 3.  Kidney, left, tumor #2, resection: Renal cell carcinoma, papillary type ! with incipient lesions scattered throughout the renal parenchyma. The inked margin is free of tumor. Kidney, left, tumor #3 and #4, resection: Renal cell carcinoma, papillary type I with areas of clear cel differentiation. Tumor approaches the black-inked margin.. 5.  Kidney, left, base of margin for tumor #3 and #4, resection: Renal parenchyma with incipient lesions and calcifications. 6.  Kidney, left, base of margin for tumor #3 and #4 (final), resection: Renal parenchyma. 7.  Kidney, left, tumor #5, resection: Renal cell carcinoma, papillary type I.. Kidney, left, tumor #6, resection: Renal cell carcinoma, papillary type I with incipient lesions. 8 9. Kidney, left, tumor #7, resection: Renal cell carcinoma, papillary type I. 10. Kidney, left, tumor #8, resection: Renal cell carcinoma, papillary type I. 11. Kidney, left, tumor #9, resection: Renal cell carcinoma, papillary type I. 12. Kidney, left, base of tumor #2, resection: Renal cell carcinoma, papillary type I. Page 1 of 5
+
+--- Page 2 ---
+13. Kidney, left, tumor #2, resection: Renal cell carcinoma, papillary type I with incipient lesions. Immunoperoxidase and in-situ hybridization tests performed here and used for diagnosis were developed and their performance characteristics determined by the They have not been cleared or approved by the U.S. Food and Drug. Administration. The FDA has also determined that such clearance or approval is not necessary. This laboratory is certified under the Clinical Laboratory Improvement Amendments of (CLiA) as qualified to perform high complexity clinical laboratory testing. CLINICAL INFORMATION: Allocate Order to Brief Clinical History: male with hereditary papillary type 1 renal cell cancer. PROcEDuRE: Left adrenalectomy and left partial nephrectomy.. SPECIMENS SUBMITTED: 1. ADRENAL MASS, LEFT, (1FS) 2. TUMOR, Left kidney # 1 3. TUMOR, Left kidney # 2 4. TUMOR, Left kidney # 3 & #4 5. TUMOR, Left kidney base of margin 3&4 6. TUMOR, Left kidney base margin 3&4 # 2 final 7. TUMOR, Left kidney tumor # 5 8. TUMOR, Left kidney # 6 9. TUMOR, Left kidney # 7 10. TUMOR, Left kidney # 8 11. TUMOR, Left kidney # 9 12. TUMOR, Left kidney base # 7 13. TUMOR, Left kidney # 10 INTRAOPERATIVE CONSULTATION: 1FS: "Left adrenal mass' 1FS Diagnosis: Adrenal cortical tumor. The above findings were communicated to the clinical team with. GROss DEscRIPTION: Received fresh from the OR are 13 separate specimens, labeled with the patient's name, medical record number, and further specified as follows:. 1. "Left adrenal mass" consisting of a yellow encapsulated nodule and associated fat measuring in aggregate 5.0 x 4.0 x 3.0 cm and weighing 36.2 grams. The capsule was focally disrupted when received. The specimen is sectioned to reveal golden yellow, nodular cut surface with focal hemorrhage. A representative section from the center of nodule is frozen as "1Fs." Gross pictures are taken. The specimen is inked black and placed into Patient Identification Page 2 of 5
+
+--- Page 3 ---
+formalin for permanent processing. Approximately 2.0 x 1.5 x 0.5 cm of tissue is procured for. The procurement was performed and documented by on at  Received in Surgical Pathology. is a specimen matching the above description. The specimen is serially sectioned and representative sections are submitted into cassettes labeled #1A-F. Additionally received is a green cassette labeled 1FS", the contents of which are entirely transferred to an orange cassette labeled. 1FS. The remaining. tissue is returned to formalin. 2. "Tumor #1 left kidney" is a portion of kidney, overall 4.8 x 4 x 3.6 cm. It is largely comprised of a red-orange. tumor (4.7 cm in greatest dimension) with a clear margin of kidney parenchyma (0.5 cm in maximum thickness). It is bisected by in the OR, revealing a variegated red-orange friable cut surface with approximately 20% of hemorrhage and necrosis. Gross photographs are taken. Core biopsies are obtained by. for their research. Approximately 35% of what appears to be viable tumor and approximately 0.5 x 0.5 x 0.3 cm of normal- appearing kidney parenchyma are procured by in the OR for the lab and documented by. on at The remainder of the specimen is placed into formalin and submitted to. Pathology for permanent processing. Received in Surgical Pathology is a specimen matching the above description. The specimen is oriented with and the portion that she indicates as "surgical margin' is inked in black. Serial sections are taken through this inked margin and are entirely submitted in cassettes labeled #2A-L. A cross section of the tumor surface is submitted in cassette. The remainder of the tissue is returned for formalin. 3. "Tumor #2 left kidney" is a portion of kidney, overall 3.5 x 3 x 3 cm. It is largely comprised of a yellow tumor (3.5 cm in greatest dimension) with a portion in which normal kidney kidney parenchyma covers it. Where the. tumor protrudes, the tissue is inked black. are informed of a gross positive tumor margin by in the OR on  Core biopsies are obtained by. for their research.. The tumor is bisected revealing a yellow soft and slightly myxoid cut surface. Gross photographs are taken. Approximately 35% of the viable-appearing tumor and approximately 0.2 x 0.2 x 0.2 cm of normal-appearing kidney parenchyma are procured by and documented by The remainder of the specimen is placed into formalin and submitted to Pathology for permanent. processing. Received in Surgical Pathology is a specimen matching the above description. The specimen is. oriented with the portion inked in black which represents the margin of resection is serially. sectioned and entirely submitted in cassettes labeled The remaining tissue is returned to formalin. 4. "Left kidney tumor #3 and #4" is a portion of kidney, overall 5 x 4 x 2.7 cm. It consists of an aggregate of. abutting tumor nodules with a rim of kidney parenchyma. The nodule identified by as nodule #3 (2 cm in greatest dimension) is inked blue by The nodule identified by.. as nodule #4 (2.7 cm in greatest dimension) is inked orange. The surgical margin is identified and inked black. In the OR, of a positive gross margin. Nodule #3 has a viable-appearing homogeneous yellow soft cut surface. Nodule #4 has a mostly friable red-yellow variegated and hemorrhagic, necrotic cut surface. Gross photographs are taken. A portion of the more viable-appearing nodule (nodule #3) is minced and submitted in glutaraldehyde for studies, per request. Core biopsies are obtained by Patient Identification. Page 3 of 5
+
+--- Page 4 ---
+tumor #3 and #4 for the lab. Approximately 35% of tissue from nodule #3 and 20% of tissue from nodule #4 are procured for lab by. and documented by The remainder of the specimen is placed into formalin and submitted to Pathology for permanent processing.. Received in Surgical Pathology is a specimen matching the above description. The black inked portion of the specimen which corresponds to the surgical margin is serially sectioned and entirely submitted in cassettes.  Representative sections of the tumor inked in blue corresponding to tumor #3 are submitted in cassettes  Representative sections of the tumor inked in orange corresponding to tumor #4 are. submitted in cassettes The remaining tissue is returned to formalin. 5. Received fresh is a specimen labeled with the patient's name, medical record number, and further specified "base margin tumor 3 + 4 left kidney" consisting of a single tan-yellow soft tissue fragment measuring 0.8 x 0.3 x 0.2 cm which is filtered into a biopsy specimen bag and entirely submitted in cassette. 6. "Left kidney base margin 3 + 4 #2 final" consisting of a single yellow-tan soft tissue fragment measuring 0.7 x 0.4 x 0.2 cm which is filtered into a biopsy specimen bag and entirely submitted in a cassette labeled. #6. 7. "Left kidney tumor #5" consisting of a single yellow-tan soft tissue fragment measuring 0.8 x 0.6 x 0.5 cm. which is bisected and entirely submitted in a cassette labeled. 8. "Left kidney tumor #6" consisting of a single yellow-tan nodule measuring 0.8 x 0.6 x 0.5 cm which is bisected and entirely submitted in a cassette labeled. #8. 9. "Left kidney tumor #7" is a portion of kidney, overall 1.3 x 1.3 x 1 cm. It is comprised mostly of a well- circumscribed, spherical yellow tumor (1 x 0.8 x 0.7 cm). The external surface is inked black by. in the. of a possible grossly positive margin. The tumor is bisected. revealing a homogeneous yellow, soft cut surface. Approximately 30% of the tumor is procured for lab by in the OR and documented by Gross photographs are taken. The remainder of the specimen is placed into formalin and submitted to Pathology for permanent processing.. Received in Surgical Pathology is a specimen matching the above description measuring 1.0 x 1.0 x 0.6 cm. It is bisected and entirely subrnitted in a cassette labeled. #9 10. "Left kidney tumor #8" consisting of a single yellow-tan soft tissue fragment measuring 0.9 x 0.5 x 0.3 cm which is entirely submitted in a cassette labeled. #10. 11. "Left kidney tumor #9" consisting of a single yellow-tan soft tissue fragment measuring 0.6 x 0.5 x 0.4 cm which is entirely submitted in a cassette labeled. #11. 12. "Base of tumor #7 left kidney" consisting of 3 distinct yellow-tan soft tissue fragments measuring in aggregate 1.0 x 0.8 x 0.5 cm which are entirely submitted in a cassette labeled #12. Page 4 of 5
+
+--- Page 5 ---
+13. "Left kidney tumor #10" is comprised of five tumor fragments ranging from 0.5 to 1.7 cm in greatest dimensions and in the aggregate 1.7 x 1 x 0.3 cm. There is a separately received irregularly--shaped portion of normal-appearing kidney parenchyma (2.3 x 1.2 x 0.4 cm). Gross photographs are taken. Margin assessment is not requested, per  on this specimen. Approximately 30% of each of the tumor fragments and 10% of the normal-appearing kidney parenchyma are procured forIab in the OR by  The remainder of the specimen is placed into formalin and submitted to Pathology for permanent processing. Patient Identification Page 5 of 5
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diff --git a/output/text/7a65d3c3-c1f4-47c9-ba9a-ed9cec99b3dd.txt b/output/text/7a65d3c3-c1f4-47c9-ba9a-ed9cec99b3dd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..99d7b419cf351d9473f20d6edc00b6b64ee6b9c7
--- /dev/null
+++ b/output/text/7a65d3c3-c1f4-47c9-ba9a-ed9cec99b3dd.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+TcDs-3 SURGICAL PATHOLOGY mucerorss, ngrgIce0l chism#hobk tiype  83t7|3 Case Number : Diagnosis: A: Lymph node, left para-aortic, biopsy 0J 8/9[13 - No metastatic carcinoma identified (0/1). B: Lymph nodes, left para-aortic, removal - No metastatic carcinoma identified (0/6) C: Renal mass, left, partial nephrectomy Tumor histologic type: Eosinophilic variant of chromophobe renal cell carcinoma Sarcomatoid features: Not identified. Histologic grade: 1 (of 4, Fuhrman classification) Tumor size: 6.0 cm Tumor focality: Unifocal Extent of invasion:. Extra-capsular invasion into perirenal adipose tissue: Not involved Venous: Absent UUID:F0A3D7E1-CDAF-4BD4-8D55-3F129A9BAC21 TCGA-UW-A72R-01A-PR Lymphatic: Absent. Redacted Surqical margins: Renal parenchymal margin: Negative Renal capsular margin: Negative Perinephric adipose tissue margin: Negative. Adrenal gland: Not submitted Lymph nodes: Separately submitted, see A and B above Pathologic findings in non-neoplastic kidney: None AJcc Stage: pT1b pN0 This staging information is based on information available at the time of this report, and is subject to change pending clinical review and additional information.
+
+--- Page 2 ---
+Comment: The neoplasm is comprised of sheets of cells with pleomorphic. nuclei without nucleoli. The .neoplastic cells have eosinophilic, granular cytoplasm with perinuclear clearing, and distinct cellular borders. Immunostains show reactivity for ck7 and cDll7, with no reactivity for vimentin or Rcc. There is focal cytoplasmic reactivity for colloidal iron. Morphologic and. immunophenotypic findings support a diagnosis of eosinophilic variant of chromophobe renal cell carcinoma, and serve to exclude oncocytoma, conventional Rcc, and type 2 papillary Rcc. Intraoperative Consult Diagnosis: A frozen section consultation was requested by Dr. in FsAl: Lymph node, left periaortic, biopsy - No tumor seen Drs. at Frozen Section Pathologist:, Clinical History: year-old female with possible Tlb renal cell carcinoma. Gross Description: Received are three appropriately labeled containers. Container A is received fresh for frozen section, and additionally labeled "left periaortic lymph node." It holds a 1.9 x 1.2 x 0.5 cm lymph node candidate which is bisected and totally submitted in block FsAl, Container B is additionally labeled "left para-aortic lymph. node." It holds a 1.5 x 1.3 x 0.9 cm aggregate of tan to yellow. fatty soft tissue fragments. Dissecting the fat reveals multiple. lymph node candidates ranging from 0.3 to 1.2 cm in greatest. dimension. Block summary:. B1 - largest lymph node candidate, serially sectioned B2,B3 - multiple lymph node candidates Fat remains in the container. Container c is additionally labeled "left renal mass." It holds a partial nephrectomy specimen (6.2 x 6.0 x 4.3 cm, 78 grams).
+
+--- Page 3 ---
+The external surface is a smooth tan renal capsule with no disruptions. The capsule is inked black and the renal parenchymal margin is inked blue. The specimen is serially. sectioned to reveal an encapsulated, roughly spherical mass that comprises the majority of the specimen (6.0 x 4.5 x 4.0 cm). The mass has a heterogeneous tan/brown cut surface with numerous areas of necrosis and hemorrhage. The mass abuts and distorts the capsule, but does not appear to disrupt the renal capsule. The fibrous capsule of the mass extends to the renal parenchymal margin but does not appear to invade. Representative sections of the mass at the capsule are submitted in blocks c1 and c2, and representative sections of the mass at the renal parenchymal. margin are submitted in blocks c3 and c4..
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diff --git a/output/text/7a8149b2-84af-4fc1-9d50-94c6f6805a63.txt b/output/text/7a8149b2-84af-4fc1-9d50-94c6f6805a63.txt
new file mode 100644
index 0000000000000000000000000000000000000000..782592844f0aea293cbcf0c704c509db36599e83
--- /dev/null
+++ b/output/text/7a8149b2-84af-4fc1-9d50-94c6f6805a63.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID: 0F2464F7-4108-4700-B2EC-17BC6C432D42 TCGA-AR-A24W-01A-PR Redacted Final Diagnosis Yas/+ Breast, right, total mastectomy: Infiltrating ductal carcinoma, Nottingham grade II (of III), (tubules 3/3, nuclei 2/3, mitoses 1/3; Nottingham score 6/9], forming a 2.1 x 1.4 x 1.1 cm mass located in the central breast (AJCC pT2). Ductal carcinoma in situ, intermediate nuclear grade, comprising approximately 5-25% of tumor volume. Angiolymphatic invasion is present. The non- neoplastic breast parenchyma shows proliferative fibrocystic changes. Calcifications present in malignant ducts. Biopsy site changes present. The tumor does not involve the nipple, overlying skin, or underlying chest wall. All surgical resection margins, including deep margin, are negative for tumor (minimum tumor free margin, 2.1 cm, deep margin).. Lymph nodes, right axillary sentinel Nos. 1A, 1B, 1C and 2, sentinel biopsy: Three (of 4) right axillary sentinel lymph nodes are positive for metastatic carcinoma (>2.0 mm) [AJCC pN1(sn) ]. Extranodal extension is not present. Blue dye is identified in lymph nodes Nos. 1A and 1B. Lymph node No. 1C does not contain blue dye.. Lymph nodes, right axillary, dissection: Multiple (18) right axillary lymph nodes are negative for tumor.. Breast, left, total mastectomy: Ductal carcinoma in sity, micropapillary and cribriform types, low nuclear grade without. intraluminal necrosis, involving an area over 5.7 x 2.3 x 1.4 cm [AJCC pTis]. The non-neoplastic breast parenchyma shows nonproliferative fibrocystic changes. Calcifications are present in malignant ducts. Biopsy site changes are present. Nipple and skin are without diagnostic abnormality. All surgical resection margins are negative for tumor (minimum tumor free margin, 1.5 cm, deep margin).  bifaterat breast CA. 1cs-0-3 carcinome, njilmeting duct Nos 8500/3 Sit: brsst Nos C50.9 M 4/25/
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diff --git a/output/text/7a8d02cd-71b6-4a24-a2be-9060e030024f.txt b/output/text/7a8d02cd-71b6-4a24-a2be-9060e030024f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c649708953fe619d661f6636407069209cb34817
--- /dev/null
+++ b/output/text/7a8d02cd-71b6-4a24-a2be-9060e030024f.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+FiNal DiAGnoSiS: LEFT COLON, SEGMENTAL COLECTOMY -  POLyPOID ADeENOCARCINOMA, WELL TO MODERATELy DIfFERENTIATED, 2.0 CM, iNVASIVE INTO THE SUBMUCOSA. B.  LYMPHOVASCULAR INVASION IDENTIFIED (CONFIRMED WITH IMMUNOSTAINS FOR CD31 AND D2-40).I C.  NO TUMOR SEEN IN THIRTEEN LYMPh NODES (0/13). D.  UNINVOLVED COLON WITH NO SPECIFIC ABNORMALITY, INCLUDING PROXIMAL AND DISTAL RESECTION MARGINS. E. PATHOLOGIC STAGE: pT1 N0 MX. CASE SYNOPSIS: SYNOPTIC DATA - PRImARY COLON, RECTAL, APPENDIX TUmORS SPECIMEN TYPE: Left nemicolectomy TCGA-AZ-4313 TUMOR SITE: Left (descending) colon TUMOR CONFIGURATION: Exophytic (polypoid) TUMOR SIZE: Greatest dimension: 2.0 cm Additional dimensions: 2.0 X 0.5 cm. INTACTNESS OF MESORECTUM: Not applicable HISTOLOGIC TyPE: Adenocarcinoma HISTOLOGIC GRADE: Low-grade (well to moderately differentiated) PATHOLOGIC STAGING (pTNM); pT1 pN0 Number of nodes examined: 13 Number of nodes involved: 0 pMX MARGINS: Proximal margin uninvolved by invasive carcinoma Distal margin uninvolved by invasive carcinoma Circumferential (radial) margin - Not applicable Mesenteric margin uninvolved by invasive carcinoma ANGIOLYMPHATIC INVASION: Indeterminate PERINEURAL INVASION: Absent TUMOR BORDER CONFIGURATION: Infiltrating TUMORAL LYMPHOCYTIC RESPONSE: Mild to moderate
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diff --git a/output/text/7af23392-bb24-4340-b3a4-1f68e10ecbbf.txt b/output/text/7af23392-bb24-4340-b3a4-1f68e10ecbbf.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e7f7f10c185fca90be27032b0afb011dc5e48bba
--- /dev/null
+++ b/output/text/7af23392-bb24-4340-b3a4-1f68e10ecbbf.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+TCGA-BP-4961 Accession #: Date of Procedure: Date of Receipt: Date of Report: Account #: Billling Type: Additional Copy to: Clinical Diagnosis & History: H/O epigastric pain with incidental renal mass discovered. Specimens Submitted: 1: SP: Kidney, right, partial nephrectomy 2: SP: Kidney, right, deep margin #2, excision 3: SP: Kidney, right, deep margin #3,excision 4: SP: Kidney, rIght, deep margin'#4, exclsion DIAGNOSIS: SP: Kidney, right, partlal nephrectomy Tumor Type: Renal cell carcinoma - Conventional (clear cell) ype The tumor shows focal ossification. Fuhrman Nuclear Grade: Nuclear grade II/IV Tumor Size: Greatest dlameter is 3 cm. Local Invasion (for renal cortlcal types): Not Identified Renal Vein Invasion: Not identified Surgical Margins: Free of tumor Non-Neoplastic Kidney:  Unremerkable Adrenal Glend: Not identlfied Lymph Nodes: Not identified Staging for renal cell carcinoma/oncocytoma:  pT1 Tumor <= 7.0 cm in greatest dimenslon limited to the kidney 2. SP: Kidney, right, deep margln #2, excision Benign blood vessel. Page 1 of 3
+
+--- Page 2 ---
+3.  SP: Kidnay, right, deep margin #3,axcision Benign renal parenchyma. 4.  SP: Kidney, right, deep margin #4, excision Benign renal paranchyma. t ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Gross Description: 1} The specimen is recaived for frozen section, labaled *Right renal tumor". It consists of a single segment of. wedge-shaped renal tissue that measures 5 x 4 x 4 cm in gteatest dimension. The surgical margin of the specimen is inkod black. A stifch is present on the surgical margin and this area is submitted for frozen diagnosis. The apposite aspact of the specimen reveals a larga amount of fatly tissua that is grossly unremarkable. This aspect of tissue is inked blue. The tissue is cross-sectioned, ravealing a bright yellaw and somewhat hemorrhagic tumor losion that measures 3.0 x 2.5 x 3.0 cm. The tumor is approximataly O.1 cm from the deep surgical margin. A sample of tumor is submitted to TPS. Grossly, tha lumor is confined to the kidney. The specimen is represontatively submilted. Summary of Sectlons: TUMR - Tumor sactians T - Tumor with fat The specimen is received in formalin, labeled "Doop margin #2 right kldney". it consists of a single small fragment of tan tissue that measures 0.5 x 0.2 x 0.1 cm. The tissua is entiraly submitted.. Summary of sections: U - undesignated 3) The specimen is received in formatin, labeled "Deep margin #3 right kidney".  It consists of two fragments of tan small tissue that measures in aggregate 0.5 x 0.2 x 0.1 cm. Tha tissua Is entirely submilted.. Summary of sections: U - undesignated 4) The speciman is racaived in formalin, labeled "Deap margin #4 right kidney".  It conslsts of a singla fragment of tan firm tissue that measures 1.0 x 0.1 x 0.2 cm. The tissuo is entirely submitted. Summary of sections: U - undesignated Summary of Sections: Part 1: SP: Kidney, right, partial nephrectomy Block Sect. Sita. pCs 2 fat 2 1 fsc 1 6 tumr 6 Page 2 of 3
+
+--- Page 3 ---
+SURGICAL PATHOLOGY REPORT Part 2:  SP: Kidney, right, deep margln #2, excision. Block Sect. Site  PCs 1 1 4 Part 3: SP: Kidney, right, deep margin #3,oxcistor. Block Sect. Site pCs 1 u 1 Part 4: SP: Kidney, right, deep margin #4, excislon. Block Sect. Site PCs Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the. tissue sample examined at the time of the Intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS: STITCHED MARGIN BENIGN. FAVOR CLEAR CELL CARCINOMA PERMANENT DIAGNOSIS: Sane Page 3 of 3 END OF REPORT
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diff --git a/output/text/7b0297a6-0b94-4c5d-82ef-b7e9ba19e4ca.txt b/output/text/7b0297a6-0b94-4c5d-82ef-b7e9ba19e4ca.txt
new file mode 100644
index 0000000000000000000000000000000000000000..91c83fcede1719f81d510e14ae55ba710e92dba2
--- /dev/null
+++ b/output/text/7b0297a6-0b94-4c5d-82ef-b7e9ba19e4ca.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UUID:5E21E07E-BD5F-4AC7-985A-178416D756E2 TCGA-C8-A26Z-01A-PR Redacted IRB APPROVED Multt-media systems, Inc. Form Revised Clinical Case Report. Jcs-o-3 (For Collection of Cancerous Tissue) Carcnomo, mfilmatmy 8500/3 duct, Nos Site; busst, Nos c50.9 hws 5/24fn Informed Consent J SSun :I personally informed this patient that a specimen(s) would be collected to be used for research. purposes. I reviewed the RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Signature Date Name of Physician or Study Coordinator Clinical Information SNEAGENERALINFORMATONSSTS Date of Birth (mm/dd/yy) Height Marital Status Race. Temperature A Married 370 c  Single  Divorced  Widow  Blood Pressure Heart Rate Gender Weight 100/g0mmitj  Male Female HISTORYOFPRESENTILLNESS Chief Complaints: The siiyht brenit-I Symptoms: Dahet Clinical Findings: Iutbe bp He reylt Breort Axily m Performance Scale (Karnofsky Score):   60-70 Symptomatic, in bed less than 50% of day  100 Asymptomatic  80-90 Symptomatic but Fully Ambulatory  20-30 Bed Ridden  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden CURRENTMEDICATIONS Frequency Date (mm/dd/yyyy) Drug Dose Route 1 To / To To To To
+
+--- Page 2 ---
+:* +  7 PAST MEDICAL HISTORY Diagnosis/Disease/Disorder/Injury  Diagnosis Date Treatment Status Besur SOB/GYN HISTORY**. . Date of First Mensesd # of Pregnancies Menopausal Status  Pre-menopausal yearsrep Dat I ast Menses # of Live Births  Peri-Menopausal Post-menopausa! years rf Birth Control:  Condom  Oral Contrace...e  iUD  Hormone Replacement /A Therapy:  Other: RSOCIALHISTORWAR. .... Occupation: Environmental Hazards: Smoking History. Duration When Quit Current Status TYPE Packs/day (yrs) (yr)  yES NO Alcohol Consumption Drinks/day Duration When Quit Current Status TYPE (yrs) (yr) DYES tNO Drug Use Frequency Duration When Quit Current Status TYPE (yrs) (y  yes t NO HSFAMIEYMEDICALHISTORYS  Diagnosis Age of Diagnosis. Relative No br? Cauy LABDATA  Result Date Result Date Test Test CEA   Negative  Positive:  HIV  Negative  Positive: CA 15-3  Negative  Positive: Hep B  Negative  Positive: 7 CA 19-9  Negative  Positive:  Hep C  Negative  Positive: PSA  Negative  Positive: AFP   Negative  Positive: Other:  Negative  Positive: Other:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+DIAGNOSTIC STUDIES  Study  Results Date Ultrasound 1 N 54Ue X-Ray CT Endoscopy MRI Biopsy * CLINICAL DIAGNOSIS  .. Preoperative Clinical Diagnosis Rinlt brecf Location of Suspected Involved Lymph Nodes. Location of Suspected Distant Metastasis. Arllley NO IClinical Staging Date of Diagnosis Tg NI M o Stage: Treatment Information .AAPLKSURGICAL TREATMENTST Procedure Date of Procedure Phtey's swrgery. Primary Tumor Organ  Detailed Location Size Reeaet Leli 19.Sx x cm Extension of Tumor N Lymph Nodes Description Location of Lymph Nodes # of Lymph Nodes Palpable, Non-Dissected Lymph Nodes. Axlla 13 Dissected Lymph Nodes Distant Metastasis  Organ Detailed Location Size M Surgical Staging T9. No. Mo Stage:L NEOADJUVENTHERAPY (Chemo Radiaton Immuno Hormonal orMolecular . Dose Route Frequency Date (mm/dd/yyy) Drug/Treatment To iVU To / To 1 1 To / / 1 1 To 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Date: ime: Collected by: fime: Preserved by: . SPECIMENTYPE # of samplesovided) Stide  Paraffin Biock Blood/Serum/Plasma Frozen Diseased  Normal Diseased  Normal  Normal Diseased  Normal Diseased x x Time to LN2 ++a. Time to Formalin Time to LN2 for min  ts min min /1 . SR PATHOEOGICALDESCRIPTIONTS Primary Tumor Extension of Tumor  Distance to NAT Organ Size. N O 2 cm Rgreat cm Lymph Nodes # Metastasized # Examined Location 13 0 Axilg Distant Metastasis Size Detailed Location Organ Pathological Staging M 0 Stage: ICA . pT a No Notes:
+
+--- Page 5 ---
+COnSOLIdaTEd DIagnOsTIC pAthOLOgy fORm* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION Diffuse + STRUCTURAL PATTERN Mosaic Streaning Necrosis  Storiform Lymphocytic Infiltration XFibrosis Vascular Invasion  Palisading Chusterized Cystic Degeneration Alveolar Formation Bleeding Indian File Myxoid Change Psanmoma/Caicification 2. Cellular features. Squamous +-Adenomatous Sarcomatous  Sguamoid Cell Glandular cel! Lymphomatous Round Cell Spindle Cell Cell Stratification Larre CeH Fibroblast Keratin Small Cell  Secretion X Osteoblast Desmosome  RS CeIVRS Like Intracyt. Vacuole Lipoblast Inflam. Cell Pear!  Gland formation Myoblast Plasma Cell Otherwise Specified: d71% sL7% 07712 2.Cellular Differentiation: Well Moderately Poor S Nuclear Atypia: Nuclear Appearaace  Aniso Nucleosis Hyperchromatism Nucleolar Prominent Multinncleated Giant Cell Mitotic Activity Nuckear Grade Histological Diagnosis: sh/tg/ms Ductal Caeefroq. Wos, G-s Comments: Director, Researctr Pathology PATHOLOGIST STAFF FOR RESEARCH USE OMLY). *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND :
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diff --git a/output/text/7b0570cf-921d-4f4d-9965-0399d7aa6380.txt b/output/text/7b0570cf-921d-4f4d-9965-0399d7aa6380.txt
new file mode 100644
index 0000000000000000000000000000000000000000..cad73124df626766ecf65d71386ad3a33a16796d
--- /dev/null
+++ b/output/text/7b0570cf-921d-4f4d-9965-0399d7aa6380.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:9A8836F2-6D40-48B9-AB0B-1761AFA16EC7 TCGA-F9-A97G-01A-PR Redacted TSS Patient ID: Surgical Date: Gross Description: Renal tumor is located in a pole, moderately-margin, soft, solid, or yellow, gray surface with 4x4x3.5cm in size. Microscopic Description: Tumor is high density and is composed of trabeculae or elongated tubules or  papillary, back to back, variability in shape and size, lined by moderrately straitified cylindrical or cuboidal cells. Nuclei are irregular large, hyperchromatic with prominent nucleioli. Mitoses are present. Cytoplasm are moderate, eosinophilic or clear. Tumor invades into capsule. Diagnosis Details: Renal cell carcinoma, papillary type ICD0-3 Comments: Carcnsia, yoapislary reral ce0Q 826Df3 Formatted Path Reports: KIDNEY TISSUE CHECKLIST Sut DKidny NOS Cb4.9 Specimen type: Radical nephrectomy. 5417[4 Tumor site: Kidney Tumor size: 4 x 4 x 3.5 cm Focality: Not specified. Histologic type: Renal cell carcinoma, papillary Histologic grade: Moderately differentiated. Tumor extent: Extension to perinephric tissues Lymph nodes: Not specified. Lymphatic invasion: Not specified. Venous invasion: Not specified. Margins: Not specified Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Tumor invades capsule, left Comments: None.
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diff --git a/output/text/7b371cfd-eae5-4236-aed0-e87672331799.txt b/output/text/7b371cfd-eae5-4236-aed0-e87672331799.txt
new file mode 100644
index 0000000000000000000000000000000000000000..99f4d42a703bfebea7b91f77248e6e70e86d49db
--- /dev/null
+++ b/output/text/7b371cfd-eae5-4236-aed0-e87672331799.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+1es-0-3 Carcii`onn,mnf2f^sHwg dutal.N0s 85oo/3 Bip: Oresot. c50. hw 4H19/1 Nos MRN: Surderv OV Age: Y DOB : Laboratory Patient Report Print Date/Time: Surgical Pathology Histopathological Examination Path#: Collected: Received: Complete: Pre-Op Diagnosis : Right Breast Cancer Order Physician : Specimens  Breast, right breast, white/lateral, black/superior. Frozen Diagnosis Report :  GROSS EXAMINATION: The specimen is received in a container labeled with the name of the patient and identified as breast, right breast. The specimen  consists of a simple mastectomy measuring en. bloc 15.5 x 9.5 x 3.1 and weighs 115 grams. There is an anterior ellipse of skin measuring 16.5 x 7.5 cm with an eccentric 2.7  cm areolar complex with everted nipple. Sections of nipple areola are sampled in block 1. The skin surface shows a 4 cm long scar located near the lateral margin and is sampled in~block 2. The superficial superior. margin is inked orange and the superficial inferior margin is Inked green. The deep margin is inked black and the specimen sectioned, showing a firm pale tan mass measuring 4.2 x 3.7 x 2.9 cm. The mass is located in the upper inner and lower inner quadrants..  The mass grossly extends to the. inked deep margin and is 1.7 cm from the superficial. superior margin and 1.9 cm from the superficial inferior margin. The skin overlying the mass is disrupted.  Sections breast is composed of yellow lobulated adipose tissue admixed with 1slands of gray-white rubbery tissue.. breast is divided into four quadrants, upper inner, The inner, upper outer and lower outer and sampled in blocks lower 8-1l respectively.  No axillary tissue is grossly. identified. Formalin fixation time is approximately 12 hours. DIAGNOSIS BASED ON GROSS AND MICROSCOPIC EXAMINATION: Breast, right simple mastectomy:. Invasive ductal carcinomayof breast, grade 2, extending to within 0.4 mm of the deep margin (see cancer case summary THIS CONFIDENTIAL AND PRIVILEGED DOCUMENT/INFORMATION IS PROTECTED BY FEDERAL AND STATE LAW.  UNAUTHORIZED DISCLOSURE, DISSEMINATION OR DUPLICATION_IS PROHIBITED UUID:A7C7D409-D086-4A9B-8C8F-E7E231D5891D Path #: TCGA-AC-A23H-01A-PR Redacted Visit #:
+
+--- Page 2 ---
+check Tumor present within dermis and dermal lymphatics.. SPECIMEN: Total breast (including nipple and skin) PROCEDURE: Simple mastectomy LYMPH NODE SAMPLING: No lymph nodes present SPECIMEN INTEGRITY:  Single intact specimen (margins can be evaluated) SPECIMEN LATERALITY: Right Tumor siTE (Invasive Carcinoma): Upper an lower inner. quadrant TUMoR SIzE (Invasive Carcinoma): Greatest dimension: 4.2 x 3.7 x 2.9 cm TUMoR FocALITy: Single focus of invasive carcinoma MACROSCOPIC AND MICROSCOPIC EXTENT OF TUMOR: Skin: Invasive carcinoma directly invades into the dermis without skin ulceration Nipple: Dcis does not involve nipple epidermis Skeletal Muscle: No skeletal muscle present DUCTAL CARCINOMA IN SITU (DCIS): No DCIS is preSent LOBULAR CARCINOMA IN SITU (LCIS):  Not identified HISTOLOGIC TYPE OF INVASIVE CARCINOMA: Invasive ductal carcinoma (no special type or not otherwise specified) HISTOLOGIC GRADE: NOTTINGHAM HISTOLOGIC SCORE: Glandular (Acinar)/Tubular Differentiation: Nuclear Pleomorphism: Mitotic Count: Overall Grade: Grade 2, score 7 (scores of 6 or 7). MARGINS: Uninvolved by invasive carcinoma Distance of closest margin: 0.4 mm Specify margin: Deep margin PATHOLOGIC STAGING (pTNM) : Primary Tumor (Invasive Carcinoma)(pT): pT2: Tumor greater than 20 mm but < or = 50 mm Regional Lymph Nodes (pN): pNx: Cannot be assessed. Distant Metastasis (m): 'Not  applicable ANCILLARY STUDIES: Estrogen Receptor: Performed on another specimen (TmL accession # Results:  Immunoreactive tumor cells present. Quantitation: 1-2+, l0% of cells staining. Progesterone Receptor:. Performed on another specimen (TmL accession # Results: No immunoreactive tumor cells present. HER2/neu: Immunoperoxidase Studies: Performed on another specimen (TML Results: Positive, score 3+ Fluorescence In Situ Hybridization (Fish) for HEr2/neu: Performed on another specimen Results: Amplified, ratio 5.90 THIS CONFIDENTIAL AND PRIVILEGED DOCUMENT/INFORMATION IS PROTECTED BY FEDERAL AND STATE LAW.  UNAUTHORIZED DISCLOSURE, DISSEMINATION OR DUPLICATION IS PROHIBITED Path #: Page 2 of 3 Visit #:
+
+--- Page 3 ---
+MICRO' CIFicArIons: Present in' Aneoplastic tissue CLINICAL HISTORY: Palpable mass. SUMMARY OF PATHOLOGIC STAGING: pT2nxg2 Intradepartmental consultation obtained.. , M.D., Pathologist Electronically Signed by: MD THIS CONFIDENTIAL AND PRIVILEGED DOCUMENT/INFORMATION IS PROTECTED BY FEDERAL AND STATE LAW. UNAUTHORIZED DISCLOSURE, DISSEMINATION OR DUPLICATION IS PROHIBITED Path #: Page 3 Visit #: of 3
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diff --git a/output/text/7b3e33fd-ee26-40e5-bfe2-b7f35b320105.txt b/output/text/7b3e33fd-ee26-40e5-bfe2-b7f35b320105.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6ec4d300cf6f06fa10c8d835afb5b1f33e4d663d
--- /dev/null
+++ b/output/text/7b3e33fd-ee26-40e5-bfe2-b7f35b320105.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+1cD-0-3 Pit Sits Code: breast, hppw outu zusdrant C 5^S.f "atient: 17 CQ(F: busoK Nos c5o.9 Surgical Pathology: Fhnat. UUID:12C64846-1CB3-42E4-B307-54C7AD12F5300 Surg Path -A0IH-01A-PR Redacted CLINICAL HISTORY: S/P adenocarcinoma. Invasive adeno carcinoma of breast. GROSS EXAMINATION: A. "Left breast biopsy (AFl)", in formalin. The specimen consists of an irregular ovoid fragment of firm pink and yellow-tan tissue measuring 2 x 1.5. x 0.8 cm in greatest dimension. A portion of the specimen has been previously submitted as frozen section AFl, and portion of tissue has been previously submitted for ER/pR evaluation. The frozen section remnant is submitted in Block Al and the remaining tissue is sectioned and submitted in Block A2. B. "Left breast", fresh. The specimen is a 500 gram, 35.5 x 16 x 5.5 cm in aggregate dimension less mastectomy specimen and attached axillary dissection. The breast measures approximately 24 x 15.5 x 5.5 cm. The skin ellipse is 18.7 x 10.4 cm. The nipple is slightly atypical located on the skin surface away from the axillary tail. The nipple is 1.4 cm in diameter and is slightly depressed and surrounding areola is 4 cm in diameter. The tip of skin ellipse closes to the axillary dissection (upper outer quadrant) exhibit a recent sutured skin excision which is 4.5 cm long and is 2.7 cm from the superior upper outer surgical margin. The skin also exhibit three small purple-brown circumscribed lesion measuring from 0.1 cm to 0.2 cm in greatest dimension scattered in several areas over the surface. The surgical margin are marked with blue ink. The deep surface opposite the previously described suture excision on the skin surface exhibits a focal area of suture material which closes a 2.1 cm defect in the deep surface. This defect communicates with the biopsy cavity. The margin in this area is inked carefully. Sectioning reveals the biopsy cavity is approximately 2.5 x 2 x 1.5 cm in greatest dimension and is hemorrhagic. Surrounding the biopsy cavity is a firm, poorly demarcated tan, slightly gritty mass which is 6.2 x approximately 4 x 2.7 cm in greatest dimension. This is well demarcated from the surrounding adipose tissue in the outer quadrant, however, but extends toward the center of the specimen it becomes less easily demarcated. The breast tissue of the remainder of the specimen is firm, fibrotic with multiple cystic structures measuring up to 1 cm in greatest dimension and filled with gray-green fluid is a second. relatively circumscribed area of soft pink-tan tissue which bulges above the cut surfaces and measures 3 x 2.5 x 1.5 cm in greatest dimension. This is located more centrally but in the lower outer quadrant. The larger firm mass surrounding the biopsy cavity to within approximately 0.5 cm of the surgical margin but the fibroadipose tissue on the deep surface is easily clear over the lesions.  Tumor extends to within 1.5 cm of the superior surgical margin.. BLOCK SUMMARY: B1-B2- representative sections of mass and adjacent biopsy cavity.. B3-B5- representative sections of tumor and adjacent deep surgical margin. B6-b7- representative sections of superior surgical margin closest to tumor. B8- representative section of nipple.. B9- representative section of skin and subcutaneous tissue at surgical incision. B10- representative section of soft, tan, demarcated lesion in the lower outer quadrant. Bll- representative section through a firm area of breast tissue grossly <XXxX separate from the main lesion by approximately 2 cm also near the lower outer quadrant. B12- representative section of dense and cystic otherwise unremarkable breast tissue from the upper outer quadrant.. B13- representative section of breast tissue from lower outer quadrant. 1 of 2
+
+--- Page 2 ---
+314- representative section of dense breast tissue from upper inner quadrant. B15- representative section of dense breast tissue from lower inner quadrant. B16- representative section of breast tissue from beneath the nipple. B17- representative section from small skin lesion. The axillary dissection is approximately 13 x 10 x 2 cm in greatest dimension. The specimen is divided into the usual three levels and examined for lymph node candidates. There are numerous lymph node each of three levels. The lymph nodes measures up to 4 cm in greatest dimension. This largest lymph node is located in level I. Sectioning through this largest lymph node reveals that is appears to be completely replaced by adipose tissue. BLOCK SUMMARY: B18-B21- lymph nodes from level I as follows: B18- representative section of largest lymph node. B19- two bisected lymph node, one inked blue. B20- one bisected lymph node. B21- one bisected lymph node. B22-B25- lymph nodes from level II as follows: B22- five intact lymph node candidates. B23- one bisected lymph node candidate. B24-B25- one bisected lymph node candidate (one lymph node total in Block B24-B25). B26-B30 lymph node candidates from level III as follows: B26- eight lymph node candidates. B27- two bisected lymph node candidates, one ink blue. 328- three intact lymph node candidates. 329- one bisected lymph node candidate. B30- one bisected lymph node candidate. for Dr. INTRA OPERATIVE CONSULTATION: A. "Left breast biopsy": AFl- infiltrating carcinoma DIAGNOSIS: "LEFT BREAST BIOPSY": A. INFILTRATING CARCINOMA. B. "LEFT BREAST": EXTENSIVE INFILTRATING LOBULAR CARCINOMA (GREATEST DIMENSION IN EXCESS OF 6 CM). SEE COMMENT. METASTATIC CARCINOMA PRESENT IN TWENTY FIVE OF TWENTY SEVEN (25/27) AXILLARY LYMPH NODES. SEE COMMENT. INFILTRATING CARCINOMA EXTENDS INTO SECTIONS OF LACTIFEROUS DUCT AND NIPPLE AS WELL AS RANDOM SECTIONS OF BREAST QUADRANT. SEE COMMENT. ALL SURGICAL MARGINS APPEAR FREE OF INVOLVEMENT. cOMMEnT: Because of the multifocal and extensive nature of the tumor, exact measurement are difficult to assess. Imnunohistochemical staining for keratin on each block of lymphoid tissue reveals extensive infiltration of most lymph nodes. There does not appear to be associated extracapsular extension. Verified by: Da# 2 of 2
\ No newline at end of file
diff --git a/output/text/7b47bb17-79c2-4c61-8b91-00e312915557.txt b/output/text/7b47bb17-79c2-4c61-8b91-00e312915557.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ed6fa39b420cfd868022eea1bc2c22683fed803d
--- /dev/null
+++ b/output/text/7b47bb17-79c2-4c61-8b91-00e312915557.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+SPECIMEN: UUID:6D2FA4DD-285F-4815-9494-76B297FA04AF TCGA-PE-A5DE-01A-PR SURGICAL PATHOLOGY REPORT Redacted DOB: Sex: F Location: Date Collected: Icd-o-3 Date Received: Physician: Copy To: uyLelTa Liirg NoS 852s13 Clinical History/Diagnosis: Left breast cancer Dte DYusastNs S c3o 9 Source of Specimen(s): HJ 6Jx4/L3 1: Sentinel Nodes-left axilla 2: left breast lumpectomy 3: Margin-final medial Gross Description: Received in three parts. Source of Tissue: 1. Labeled # 1, "sentinel node left axilla" Touch Preparation Evaluation: 1TP- NO TUMOR SEEN PER (VERIFIED). Gross Description: Received fresh for intraoperative consultation/touch impression in a container labeled "sentinel node left axilla". It consists of a tan to light brown rubbery lymph node measuring 1.6 x 1.3 x 1.0 cm. There is a stitch at one end marking the bluest portion. The node is sectioned. Touch impression of the bluest end was submitted as 1TPA and the tissue is subsequently submitted in 1A. Touch impression of the opposite end was submitted as 1TPB and subsequently the tissue is submitted in 1B. ********** ***************** Source of Tissue: 2. Labeled # 2, "left breast lumpectomy" Gross Description: Received fresh in a container labeled "left breast lumpectomy". It consists of a 7.4 x 7.4 x 3.5 cm ovoid rubbery fragment of fibroadipose tissue. There is a short stitch marking the superior and a long marking the lateral. The anterior is inked blue and the remaining margins are inked black. The specimen is. sectioned disclosing a large firm tan lesion with moderately defined borders measuring 3.8 x 2.6 x 1.9 cm. The lesion occupies an appreciable. amount of the lumpectomy specimen. Laterally in the tumor there is inspissated blood consistent with previous biopsy site changes. The lesion comes very close to the medial, superior, and anterior resection margins. Also adjacently the breast parenchyma is fibrous and there is a. 0.4 cm blue dome cyst noted. Representative sections are submitted in 2A-K. 3013
+
+--- Page 2 ---
+Designation of Sections: 2A-2C- breast tissue with tumor in relationship to anterior margin, 2D-2F- breast tissue with tumor in relationship to posterior margin, 2G- additional sections of tumor, no margins are represented with biopsy site, 2H- perpendicular sections of superior resection margin, 2I- perpendicular sections of medial resection margin [Note: specimen 3 presumably supercedes this margin.], 2J- perpendicular sections of inferior margin, 2K- perpendicular sections of lateral margin *********************************************************************** Source of Tissue: 3. Labeled # 3, "final medial margin" Gross Description: Received fresh in a container labeled " final medial margin". It consists of a fragment of fibroadipose tissue measuring 2.5 x 2.0 x 1.0 cm. There is a stitch marking the final margin which is inked black prior to sectioning. Sections disclose no obvious residual lesional tissue. Entirely submitted in 3A and 3B. Final Diagnosis: 1. Sentinel lymph node, left axilla, excision: - One lymph node with no tumor seen (0/1). - Negative immunohistochemical staining for cytokeratin AE1/AE3. 2. Left breast, lumpectomy:. Invasive and in situ lobular carcinoma - Invasive lobular carcinoma, 3.8 cm in greatest dimension grossly, grade II-III. - Lobular carcinoma in situ, nuclear grade II-III, comprising approximately 5% of the tumor mass.. - Lymphovascular invasion is not identified. - Invasive carcinoma is less than 1mm to the inked closest medial margin (see specimen 3 for final medial margin status), and remaining margins with no tumor seen. - Changes consistent with prior biopsy site seen. - Non-neoplastic breast tissue shows fibrocystic changes with microcalcifications. 3. Left breast, final medial margin, excision: - Benign breast tissue, no tumor seen. Note: Case reviewed with. who concurs with the. diagnosis.
+
+--- Page 3 ---
+Procedures/Addenda Addendum Date Ordered: Status: Date Complete: By: Date Reported Addendum Diagnosis Specimen sent tc  for additional testing. Results Antibody/Tests Prognostic Grouping DNA INDEX/PLOIDY 1.59 Aneuploid S-Phase See Below Ki-67 (MIB-1) <10% Favorable An accurate S-phase fraction (SPF) value cannot be determined due to DNA aneuploid/tetraploidy cell population <20% of total cells analyzed. INVASIVE BREAST CANCER TEMPLATE: Excisions and Mastectomies Specimen Type Excision Lymph Node Sampling Sentinel lymph node only Specimen Size (for excisions less than total mastectomy) Greatest dimension: 7.4 cm Laterality Left Tumor Site(s) Not specified  Invasive Component Solitary Greatest dimension: 3.8 cm (grossly) Histologic Type(s) Lobular carcinoma in situ Invasive lobular
+
+--- Page 4 ---
+Invasive Lobular Carcinoma Type Classical, singet-ring, and pleomorphic. Invasion Invasion confined to breast parenchyma Angiolymphatic Invasion. Absent Microcalcifications Associated with Carcinoma In Situ No Margins Margins uninvolved by invasive carcinoma and in situ carcinoma Regional Lymph Nodes. 1 regional lymph node examined. No regional lymph node metastasis histologically and by immunohistochemical staining for cytokeratin AE1/AE3 (NO) Ancillary Immunopathology Studies (performed on ER Positive PR Positive Her2-Neu Negative (score 0) pTNM: T2 N0 Mx
\ No newline at end of file
diff --git a/output/text/7b704dc9-99c5-4e62-b550-77a227bee273.txt b/output/text/7b704dc9-99c5-4e62-b550-77a227bee273.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c55ce0e037962ef4301389292e144e80ea20ad89
--- /dev/null
+++ b/output/text/7b704dc9-99c5-4e62-b550-77a227bee273.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis/Diagnoses: Right hemicolectomy specimen with tumor-free resection margins, including a small tubular and a larger tubulovillous adenoma with moderate dysplasia, with an ulcerated, poorly differentiated adenocarcinoma with infiltration of the perimuscular fat tissue (G3, pT3) and a moderately differentiated adenocarcinoma with infiltration of the submucosa (G2, pT1) in the proximal large. bowel and with a detectable ulcer in the aboral section of the preparation, evidently with status post complete endocoscopic excision of a tubulovillous adenoma with severe dysplasia (cf. most recent preliminary findings). Tumor-free oral and aboral resection margins. Unremarkable appendix. Tumor-free omental tissue A follow-up report will be made on the lymph node status. Follow-up report: Only twenty-one lymph nodes of up to 0.4 cm in size in the vicinity of the tumor were dissected out from the pericolic fatty tissue after clarification with acetone.. Microscopically these were all tumor-free In conclusion, the previously diagnosed double carcinoma of the right colon can be assigned to category pN0 (0/12).
\ No newline at end of file
diff --git a/output/text/7c332179-147e-42c2-8430-59a845c701d6.txt b/output/text/7c332179-147e-42c2-8430-59a845c701d6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8079afb05443cb451336b26b7f8c579cf2a05019
--- /dev/null
+++ b/output/text/7c332179-147e-42c2-8430-59a845c701d6.txt
@@ -0,0 +1,27 @@
+
+--- Page 1 ---
+Pathology Report CORRECTED Report Type .... Pathology Report. Date of Event ... Authored by .... Hosp/Group .... Record Status .... CORRECTED. ADDENDA: Addendum MOLECULAR ANATOMIC PATHOLOGY TESTING Block 3K: A. HRAS mutation IDENTIFIED (p.Q61K, c.181C>A). B. Mutations in BRAF, NRAS61, KRAS12/13 NOT identified. C. FISH test for RET/PTC rearrangement is pending NOTE: DNA was extracted in the amount sufficient for testing. BACKGROUND: Mutations in either BRAF or RAS genes or RET/PTC rearrangements are found in more than 70% of papillary thyroid carcinomas (1). BRAF V600E (T1799A) mutation has been associated with more aggressive behavior of papillary carcinoma (2, 3). The association between BRAF V600E mutation and features of tumor aggressiveness have also been observed in papillary microcarcinomas (4). Mutations in the RAS genes or PAX8/PPARg rearrangement occur in ~70% of follicular thyroid carcinomas and with lower frequency in oncocytic (H?rthle cell) carcinomas (5). Regarding the specificity of these mutations for cancer, BRAF V600E mutation and RET/PTC and PAX8/PPARg rearrangements are overall specific for malignancy in the thyroid, although they have been reported with a very low frequency in benign thyroid lesions (6). RAS mutations occur in malignant and benign thyroid tumors, being found in ~40-50% of follicular and anaplastic carcinomas, 30-40% of follicular adenomas and 10-15% of papillary carcinomas (6). et al. Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas. 2 et al. BRAF mutation predicts a poorer clinical prognosis for  papillary thyroid cancer 3. et al. BRAF V600E mutation and outcome of patients with papillary thyroid carcinoma: a  median follow-up study.. 4. Analysis  of differential BRAF(V600E) mutational status in high aggressive papillary thyroid microcarcinoma. et al. RAS point mutations and5PAX8-PPARg rearrangement in thyroid tumors: Evidence for distinct molecular pathways in thyroid follicular carcinoma 6  Recent developments in the molecular biology of the thyroid.  Differential Diagnosis and Molecular Advances.
+
+--- Page 2 ---
+MUTATIONAL ANALYSIS: For paraffin-embedded surgical specimens, manual microdissection was performed to collect tumor tissue. Specimens with the minimum of 50% of tumor cells in a microdissection target are accepted for the analysis. Optical density readings were obtained. Real-time PCR was performed on the LightCycler platform to amplify BRAF codons 599-601, NRAS codon 61, HRAS codon 61, and KRAS codons 12/13 sequences. Post-PCR melting curve analysis was used to detect possible mutations. If required, the mutation type was confirmed by Sanger sequencing of the PCR product on ABI3130. DNA from samples positive for each of these mutations was used as positive controls. Amplification at 35 cycles or earlier was considered sufficient for the analysis. The limit of  detection is approximately 10-20% of alleles with mutation present in the background of normal DNA. My signature is attestation that I have personally reviewed the submitted material(s) and the above diagnosis reflects that evaluation.. Addendum In-situ hybridization and immunohistochemistry have been performed on the invasive squamous cell carcinoma of the larynx in Part 3 and results are as follows: STAIN POSITIVE/NEGATIVE HPV  negative P16 negative EGFR 3+ My signature is attestation that I have personally reviewed the submitted material(s) and the above diagnosis reflects that evaluation.. FINAL DIAGNOSIS: PART 1: LYMPH NODES, NECK, LEVELS 2 - 4, SELECTIVE DISSECTION  SEVENTEEN LYMPH NODES, NO TUMOR PRESENT (O/17). PART 2: LYMPH NODES, RIGHT NECK, LEVELS 2 - 4 INCLUDING LEVEL 2B, SELECTIVEI DISSECTION A. METASTATIC SQUAMOUS CELL CARCINOMA IN ONE OF FOURTEEN LYMPH NODES (2.2 CM) WITH SPINDLE CELL FEATURES (1/14). B. EXTRACAPSULAR SPREAD IS PRESENT PART 3: LARYNX AND THYROID LOBE, RIGHT, TOTAL LARYNGECTOMY AND RIGHT THYROID LOBECTOMY (12 GRAMS) A. INVASIVE SQUAMOUS CELL CARCINOMA, POORLY DIFFERENTIATED, KERATINIZING, WITH FOCAL SPINDLE CELL FEATURES, TRANSGLOTTIC, WITH SUPRA-AND  SUB-GLOTTIC EXTENSION TO THE RIGHT TRUE AND FALSE FOCAL CORDS AND LEFT TRUE VOCAL CORD (5.5 CM). B.  ANGIOL YMPHATIC INVASION IS PRESENT. C.  PERINEURAL INVASION IS PRESENT.
+
+--- Page 3 ---
+D. THYROID AND CRICOID CARTILAGE, INVASION PRESENT. E. MARGINS: THE RIGHT PYRIFORM SINUS SOFT TISSUE MARGIN AND RIGHT PRE-EPIGLOTTIC SOFT TISSUE MARGINS ARE POSITIVE FOR SQUAMOUS CELL CARCINOMA; OTHER MARGINS FREE (see also parts 5-9) F. PATHOLOGIC STAGE: pT4aN1. G. TRACHEOSTOMY WITH REACTIVE CHANGES, UNINVOLVED BY TUMOR. H. RIGHT THYROID LOBE: PAPILLARY THYROID MICROCARCINOMAS. TWO FOCI (0.9 AND 0.3 CM), CONFINED TO THYROID; NO ANGIOLYMPHATIC INVASION. PATHOLOGIC STAGE: pT1aN0. J. NON-NEOPLASTIC THYROID WITH KERATINIZING LYMPHOEPITHELIAL CYST (see comment). K. NON-NEOPLASTIC THYROID WITH NODULAR HYPERPLASIA. L.  TWO CENTRAL LYMPH NODES, NO SQUAMOUS CELL CARCINOMA OR PAPILLARY THYROID CARCINOMA PRESENT (0/2). PART 4: DEEP PYRIFORM SINUS, EXCISION INVASIVE SQUAMOUS CELL CARCINOMA PART 5: RIGHT LATERAL MARGIN, EXCISION NO TUMOR PRESENT PART 6: INFERIOR MARGIN, EXCISION NO TUMOR PRESENT. PART 7: LEFT PHARYNGEAL MARGIN, EXCISION NO TUMOR PRESENT. PART 8: SUPERIOR MARGIN, EXCISION  NO TUMOR PRESENT. PART 9: NEW RIGHT LATERAL MARGIN, EXCISION NO TUMOR PRESENT. COMMENT The keratinizing lymphoepithelial cyst in the thyroid is lined by reactive, but bland, epithelium that is distinct from the patient' s solid high grade laryngeal squamous cell carcinoma and papillary thyroid carcinomas which are of the follicular variant. My signature is attestation that I have personally reviewed the submitted material(s) and the final diagnosis reflects that evaluation. GROSS DESCRIPTION: The specimen is received in nine parts.. Part 1 is received fixed, labeled with the patient's name (initials xx) and "left neck levels 2, 3, 4." Received is an unoriented portion of fibroadipose tissue measuring 11.1 x 2.0 x 1.5 cm. The first third of the specimen contains up to eight potential soft, tan-pink lymph nodes ranging from 0.2 to 1.1 cm in greatest dimension. The middle third of the specimen contains up to two potential soft, tan-gray lymph nodes measuring 0.2 and 0.8 cm. The last third of the specimen contains no grossly identifiable lymph nodes. Cassette code: 1A 1B multiple potential lymph nodes, first third 1C multiple potential lymph nodes, middle third
+
+--- Page 4 ---
+1D adipose tissue, last third Part 2 is received fixed, labeled with the patient's name (initials xx) and "right neck levels 2, 3, 4 including 2B". Received is an unoriented portion of fibroadipose tissue measuring 12.0 x 2.5 x 1.4 cm. A 2.2 x 1.4 x 0.8 cm lymph node in the middle third of the specimen (designated level 2B) has a firm, tan-white cut surface with central necrotic material and pinpoint hemorrhages. Up to 6 other potential soft lymph nodes are identified in the middle third of the specimen ranging from 0.1 to 0.3 cm. The first, adjacent third of the specimen contains the most connective tissue and is presumed to represent level 3, having anatomically bent inferior to the middle third of the specimen. The first third of the specimen contains two soft tan lymph nodes measuring 1.3 and 2.2 cm. The opposite, last fatty third of the specimen is designated as level 4 and contains multiple potential lymph nodes ranging from 0.2 x 0.2 x 0.2 cm to 1.0 x 0.4 x 0.3 cm. Cassette code: 2A enlarged lymph node, middle third (level 2B), serially sectioned and entirely submitted 2B multiple potential lymph nodes, middle third. 2C up to two potential lymph nodes, first third. 2D multiple potential lymph nodes, last third. Part 3 is received fixed, labeled with the patient's name (initials xx) and "total laryngectomy plus right thyroid lobe". Received is a laryngectomy specimen measuring 11.0 cm (superior to inferior) x 9.0 cm (medial to lateral). x 5.5 cm (anterior to posterior). The specimen contains a tracheostomy site with 5.5 x 4.0 cm ellipse of skin, 5.5 x 3.0 x 1.5 cm right thyroid lobe with 3.0 x 2.5 x 1.0 cm portion of isthmus, and seven tracheal rings. An ulcerated, white, firm mass originates in the right glottis, measuring 5.5 cm (medial to lateral) x 4.0 cm (superior to inferior) x 3.0 cm (anterior to. posterior). The mass has supra- and infra-glottic extension, and involves the right false vocal cord, right ventricle, right true vocal cord, left true vocal cord, pre-epiglottic soft tissue, thyroid cartilage, cricoid cartilage, anterior soft tissue and muscle, and right pyriform soft tissue margin. Grossly the hyoid bone is not involved. No lymph nodes are identified in the. soft tissue. The right thyroid lobe shows a dusky tan, firm, gelatinous mass measuring 1.4. x 1.2 x 2.0 cm (12 grams) in the mid zone, with multiple tan-white, firm nodules up to 0.3 cm immediately adjacent to and within the mass. Digital photographs are taken. Tissue from the lesion and normal tissue are banked for. Ink code Red tissue bank Blue pre-epiglottic soft tissue margin Orange soft tissue exposed after removal of the hyoid bone (not true margin). Black all other margins Cassette code: 3A bilateral posterior cricoid margins, shave. 3B right pyriform sinus soft tissue margin, perpendicular. 3C right pre-epiglottic soft tissue margin, perpendicular 3D anterior soft tissue margin and thyroid cartilage, perpendicular 3E mass involving thyroid cartilage with cricoid cartilage and thyroid gland 3F right false vocal cord, ventricle, and true vocal cord 3G left false vocal cord, ventricle, and true vocal cord. 3H tracheal margin, shave 31 tracheostomy site with skin 3J 3N right thyroid nodule submitted from inferior to superior Part 4 was received fresh for frozen intraoperative consultation, labeled with
+
+--- Page 5 ---
+the patient's name (initials xx) and "deep pyriform sinus". The specimen consists of two fragments of tan-white soft tissue measuring 0.4 x 0.2 x 0.2 cm and 0.1 x 0.1 x 0.1 cm. The specimen is entirely submitted for permanent section in cassette 4AFS. Part 5 was received fresh for frozen intraoperative consultation, labeled with the patient's name (initials xx) and "right lateral margin". It consists of a tan-white soft tissue measuring 3.6 x 0.8 x 0.5 cm, with the clipped end inked in black. The specimen is entirely submitted for permanent section in cassette 5AFS. Part 6 was received fresh for frozen intraoperative consultation, labeled with the patient's name (initials xx) and "inferior margin". It consists of a portion of soft tan-white tissue measuring 5.0 x 0.6 x 0.5 cm, with the clipped end inked in black. The specimen is entirely submitted for permanent section in cassette 6AFS. Part 7 was received fresh for frozen intraoperative consultation, labeled with the patient's name (initials xx) and "left pharyngeal margin". Received is a portion of tan-white soft tissue measuring 3.5 x 0.4 x 0.4 cm, with the clipped end inked in black. The specimen is entirely submitted for permanent. section in cassette 7AFS. Part 8 was received fresh for frozen intraoperative consultation, labeled with the patient's name (initials xx) and "superior margin". Received is a portion of soft tan-white soft tissue measuring 5.5 x 0.6 x 0.5 cm, with the clipped end inked in black. The specimen is entirely submitted for permanent section in cassette 8AFS Part 9 was received fresh for frozen intraoperative consultation, labeled with the patient's name (initials xx) and "new right lateral margin, clip. superior". Received is a portion of soft tan-white tissue measuring 3.7 x 0.6 x 0.5 cm, with the clipped end inked in black. The specimen is entirely submitted for permanent section in cassette 9AFS. Dictated by: INTRAOPERATIVE CONSULTATION: 4AFS:  RIGHT DEEP PYRIFORM SINUS, EXCISION (frozen section) A. MALIGNANT. B. INVASIVE SQUAMOUS CELL CARCINOMA M.D.). 5AFS: RIGHT LATERAL MARGIN, EXCISION (frozen section) A. DEFER B. SMALL DETACHED CLUSTER OF ATYPICAL SQUAMOUS CELLS 6AFS:  INFERIOR MARGIN, EXCISION (frozen section) A. BENIGN. B. NO TUMOR PRESENT ) 7AFS: LEFT PHARYNGEAL MARGIN, EXCISION (frozen section) A. BENIGN. B.  NO TUMOR PRESENT 8AFS:  SUPERIOR MARGIN, EXCISION (frozen section) A. BENIGN. B.  NO TUMOR PRESENT 9AFS: NEW RIGHT LATERAL MARGIN, CLIP SUPERIOR, EXCISION (frozen section) BENIGN. A. B. NO TUMOR PRESENT MICROSCOPIC:
+
+--- Page 6 ---
+Microscopic examination substantiates the above diagnosis. The following statement applies to all immunohistochemistry, Insitu Hybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and. Immunofluorescent Testing: The testing was developed and its performance characteristics determined by. the Department of Pathology, as required by the CLIA regulations. The testing has not been cleared or approved for the specific use by the U.S. Food and Drug Administration, but the FDA has. determined such approval is not necessary for clinical use. Tissue fixation ranges from a minimum ofto a maximum of hours. This laboratory is certified under the Clinical Laboratory Improvement. Amendments of ("CLIA") as qualified to perform high-complexity clinical testing. Pursuant to the requirements of CLIA, ASR's used in this laboratory have been established and verified for accuracy and precision. Additional. information about this type of test is available upon request. CASE SYNOPSIS: SYNOPTIC DATA - LARYNX RESECTIONS TYPE OF LARYNGECTOMY: Total TUMOR LATERALITY:  Bilateral ATTACHED STRUCTURES: Neck dissection, Pyriform sinus, Tracheotomy,. Thyroid, Skin TUMOR LOCATION/SEGMENT:  Transglottic TUMOR SIZE:  Maximum dimension: 5.5 cm HISTOLOGIC TYPE OF TUMOR:  Squamous cell carcinoma HISTOLOGIC GRADE:  Poorly differentiated/Undifferentiated STRUCTURES INVOLVED BY TUMOR: True cord, False cord, Ventricle, Pyriform sinus, Subglottis (greater than 1 cm subglottic extension), Thyroid cartilage, Pre-epiglottic space, Extralaryngeal soft tissue LYMPH NODES:  Lymph nodes positive, Right: 1 Total number of right sided lymph nodes examined: 16 Lymph nodes positive, Left: 0 Total number of left sided lymph nodes examined: 17 EXTRACAPSULAR SPREAD OF LYMPH NODE METASTASES No INTRA-PERINEURAL INVASION: Present VASCULAR INVASION: Yes SURGICAL MARGIN INVOLVEMENT: Positive (invasive tumor) T STAGE, PATHOLOGIC: Glottis, pT4a N STAGE, PATHOLOGIC: pN1 M STAGE, PATHOLOGIC: pMX SYNOPTIC DATA - PRIMARY THYROID TUMORS SPECIMEN TYPE:  Lobectomy TUMOR SITE: Right Lobe TUMOR FOCALITY: Multifocal TUMOR SIZE (largest nodule): Greatest Dimension: 2.0 cm HISTOLOGIC TYPE**:  Papillary carcinoma PRIMARY TUMOR (pT): pT1a REGIONAL LYMPH NODES (pN):  pN0 Number of regional lymph nodes examined: 1 Number of regional lymph nodes involved: 0 DISTANT METASTASIS (pM):Not applicable EXTRATHYROIDAL EXTENSION:  Not identified MARGINS:  Margins uninvolved by carcinoma LYMPH-VASCULAR INVASION:  Not identified
+
+--- Page 7 ---
+ADDITIONAL PATHOLOGIC FINDINGS: Thyroiditis Other: Keratinizing lymphoepithelial cyst, and nodular hyperplasia. PATIENT HISTORY: CHIEF COMPLAINT/ PRE-OP/ POST-OP DIAGNOSIS: Laryngeal cancer PROCEDURE: Total laryngectomy. SPECIFIC CLINICAL QUESTION: Not provided. OUTSIDE TISSUE DIAGNOSIS: Not provided. PRIOR MALIGNANCY: Not provided. CHEMORADIATION THERAPY: Not provided ORGAN TRANSPLANT: Not provided. IMMUNOSUPPRESSION: Not provided. OTHER DISEASES: Not provided. HISTO TISSUE SUMMARY/SLIDES REVIEWED Part 1: Left Neck Level 2-4 Taken:  Stain/cnt Block H&E x 1 A H&E x 1 B H&E x 1 C H&E x 1 D Part 2: Right Neck Level 2-4 including Level 2B Taken:  Stain/cnt Block H&E x 1 A H&E x 1 B H&E x 1 C H&E x 1 D Part 3: Total Laryngectomy and Right Thyroid Lobe Taken:  Stain/cnt Block H&E x 1 A H&E x 1 B H&E x 1 c Decal x 1 D H&E x 1 D H&E x 1 E H&E Recut x 1 F IEGFR x 1 F IBNKNC x 1 F IBNKNC x 1 F IBNKNC x 1 F IBNKNC x 1 F IBNKNC x 1 F IBNKNC x 1 F H&E x 1 F HPV x 1 F IISH x 1 F P16 x 1 F V-EGFR x 1 F H&E x 1 G H&E x 1 H H&E x 1 1 H&E x 1 J
+
+--- Page 8 ---
+MAP H&E Recut x 1 K MAP H&E Recut x 1 K MAPBNK x 1 K MAPBNK x 1 K MAPBNK x 1 K MAPBNK x 1 K MAPBNK x 1 K MAPBNK x 1 K MAPBNK x 1 K MAPBNK x 1 K MAPBNK x 1 K MAPBNK x 1 K H&E x 1 K ISEQADDON x 1 K ITHY-PE x 1 iret x 1 K H&E x 1 H&E x 1 M RHHE Lev x 1 N RHHE Lev x 1 N RHHE Lev x 1 N RHHE Lev x 1 N RHHE Lev x 1 N H&E x 1 N Part 4: Deep Piriform Sinus Taken:  Stain/cnt Block H&E x 1 AFS Part 5: Right Lateral Margin Taken: Stain/cnt Block H&E x 1 AFS Part 6: Inferior Margin Taken:  Stain/cnt Block H&E x 1 AFS Part 7: Left Pharyngeal Margin Taken:  Stain/cnt Block H&E x 1 AFS Part 8: Superior Margin Taken: Stain/cnt Block H&E x 1 AFS Part 9: New Right Lateral Margin Taken:  Stain/cnt Block H&E x 1 AFS SPECIAL Procedures: In Situ Procedure Interpretation PROBE: LSI EGFR/CEP7 Dual-Color Probe Cytogenetic Location: 7p12 / 7p11.1-q11.1 3F: EGFR FISH STUDIES PERFORMED ON THE SQUAMOUS CELL CARCINOMA ARE NEGATIVE. Number of cells analyzed: 60
+
+--- Page 9 ---
+Ratio EGFR/CEP7: 1.10 High Polysomy: 0% SNR (signal to nucleus ratio): 2.6 Low Polysomy: 13(21.7%) Trisomy: 13(21.7%) Disomy: 34(56.7%) 3K: RET/PTC: The targeted area of the tissue showed O(0%) of the cells with the rearrangement pattern and 60(100%) of the cells with the normal pattern. The targeted area is considered NOT rearranged for the RET/PTC region. The RET/PTC1 Probe did not contain the rearrangement pattern.. My signature is attestation that I have personally reviewed the submitted material(s) and the above diagnosis reflects that evaluation.. Results EGFR FISH analysis was manually performed and quantitatively assessed by analysis of a minimum of 60 cells using the EGFR SpectrumOrange and the CEP7 SpectrumGreen probes. EGFR FISH positive: High Polysomy: > four gene copies in > 40% of cells. Gene Amplification: Ratio gene/chromosome more than two or > 15 gene copies in > 10% of cells EGFR FISH negative: Disomy: < two gene copies in more than 90% of the cells. Trisomy: three gene copies in more than 10% of cells. Low Polysomy: > four gene copies in more than 10% but less than 40% of cells References:
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diff --git a/output/text/7c778bf5-16d2-43cd-aa09-e6170f091198.txt b/output/text/7c778bf5-16d2-43cd-aa09-e6170f091198.txt
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index 0000000000000000000000000000000000000000..05f1f47435881bf7fc72b12840deac64a619d22f
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+ Page 1 of 2 UUID:08415C4C-C645-4911-BA53-6E562E562FD4 TCGA-G3-A6UC-01A-PR Redacted CONFIDENTIAL SUrGICaL PAThOLOgy rEPORt Time Collected Time Reported Time Received Time Transmitted Order Number Ordering Provider Status ZcD-0 -3 Final Relevant Information C 4cj Location Copied To 8170/3 pat Report Patient hepatscellorNC Oeuromos, Demographics (for (8170/3 verification purposes) Slidwaus Sex: M (8230/3) 8230/3 Code tnoheo Site Dier cx2.O SurgiCaL pathoLOgy repOrt **Surgical Pathology Report***** 9I 7/zzJ13 Accession Number Collected Date/Tir Received Date/Time Pathologist Specimen Description A. Gallbladder at B. Liver segment 6 at Clinical Information Cirrhosis secondary to eroh with likely Hcc.. Diagnosis A. Gallbladder: Cholelithiasis B. Liver segment 6: Chronic hepatitis, mild. Cirrhosis, micronodular. Hepatocellular carcinoma, moderately differentiated, solid variant,. 2.5 cms in the greast dimension, with metastases to the portal veins. and intrahepatic metastases Tumor 0.3 cm away from the resection margin. Reported by: Electronically signed by Verified: Gross Description  Received are specimen containers A to B. All requisitions and specimen containers are labelled with the patient's name. The cassettes and AP identifiers are labelled with the Surgical Number A. Specimen is received fresh.. The container is designated "A. Gallbladder". The.
+
+--- Page 2 ---
+Page 2 of 2 specimen consists of a congested intact gallbladder measuring 11.0 x 3.5 x 3.5 cm. The serosal surface is smooth and glistening. Openirg reveals the gallbladder to be filled with green bile. Also found in the gallbladder are five black irregular calculi ranging. from 0.4 cm up to 1.5 cn in greatest dimension. The mucosal surface is dark green, rough and the gallbladder wall averages between 0.1 to 0.2 cm in thickness. and near the cystic duct are two firm palpable nodules within the adipose tissue, the Found at the neck first measuring 1.0 cm, the other 1.5 cm in greatest dimension. Al Sections are as follows: - three sections of gallbladder. A2 - the smaller node bisected. A3 - the larger node bisected. B. Specimen is received fresh. The container is designated "Liver segment 6". The specimen consists of a portion of liver weighing 50.8 g and measuring 6.5 x 5.0 x 2.5 cm. The liver capsule is nodular and the surgical resection margin has been inked blue.. Sectioning reveals a green circumscribed mass measuring 2.5 x 2.3 x 2.5 cm. Adjacent to the green circumscribed mass is a hemorrhagic circumscribed mass measuring 1.0 x 1.0 x 1.0 cm. The green mass comes within o.3 cm of the blue painted surgical resection margin and the hemorrhagic mass 0.1 cm to the blue painted surgical resection margin. The green mass comes with less than 0.l cm of the liver capsule and the hemorrhagic mass comes within 0.7 cm of the liver capsule. Sections are as follows: B1 section of the yreen mass and its relationship to the liver capsule. B2 - section of the green mass and its relationship to the blue painted surgical resection margin. B3 - hemorrhagic mass with a portion of the adjacent green mass and the relationship. to the blue. painted surgical margin. B4 - further section of hemorrhagic mass and relationship to blue painted surgical. resection margin. Please note that upon sectioning of the hemorrhagic mass, it is found to have a cut surface. circumscribed area, query blood vessel. B5 - representative section of liver parenchyma. Accession Number Encounter Number Patient Location. 113 riteria PAA Discre rior Maiignar Prastate ase is (circle
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diff --git a/output/text/7c7b34ba-5b8c-480b-a481-043c67954078.txt b/output/text/7c7b34ba-5b8c-480b-a481-043c67954078.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d753dcd6ff6124223561bc07a721ba2bac48a5dc
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+
+--- Page 1 ---
+Metostatrc Lymph Node UUID:3687AF42-4BB3-46E2-8091-E0C5C84F15E6 TCGA-E2-A15A-06A-PR Redacted TSS: SPECIMENS: /cs-0-3 A. LEFT AXILLARY NON SLN #1 B. RIGHT AXILLARY SLN #1 C. RIGHT BREAST carcinoms, nfi(tneHug duct, Nos D. LEFT BREAST 8500/ 3 E. LEFT AXILLARY CONTENTS SPECIMEN(S): Site: hyph mrd, axilary cr1.3 A. LEFT AXILLARY NON SLN #1 B. RIGHT AXILLARY SLN #1 C. RIGHT BREAST w D. LEFT BREAST 3/5/14 E. LEFT AXILLARY CONTENTS INTRAOPERATIVE CONSULTATION DIAGNOSIS: TPA-left axillary non-sentinel lymph node #1: Positive for carcinoma. TPB-right axillary Sentinel lymph node #1: Negative for carcinoma. Diagnoses called by Dr. to Dr. at GROSS DESCRIPTION: A. LEFT AXILLARY NON SLN #1 Received fresh labeled with the patient's identification and "left axillary non-sentinel lymph node #1" is a 1.3 x 1.1 x 0.4 cm lymph node. Bisected, a touch prep is performed, and specimen is submitted entirely in cassette A1. B. RIGHT AXILLARY SENTINEL LYMPH NODE #1 Received fresh labeled with the patient's identification and "right axillary Sentinel lymph node #1" is a 1.2 x 1.1 x 0.5 cm lymph node. It is bisected; touch prep is performed, submitted entirely in cassette B1. C. RIGHT BREAST Received fresh labeled with the patient's identification and "right breast" is an oriented 243 g, 16 x 15 x 12 cm mastectomy with 5 x 2.5 cm skin ellipse and 1.7 cm everted nipple. Ink code: anterior/superior-blue, anterior/inferior- orange, posterior-black. Specimen is serially sectioned into 11 slices from medial to lateral with nipple in slice 4 revealing a 1.5 x 1.3 x 1.2 cm biopsy site located in the upper outer quadrant, 0.4 cm from the deep margin and less than 0.1 cm from the anterior margin. Representatively submitted: C1: slice 3, upper inner quadrant. C2: slice 5, upper inner quadrant C3: slice 7, upper outer quadrant C4: slice 10, upper outer quadrant C6-C8: slice 11, upper outer quadrant (biopsy site) C7: slice 9, lower outer quadrant C8: slice 8, lower outer quadrant C9: slice 4, lower inner quadrant C10: slice 2, lower inner quadrant C11-C12: nipple, perpendicular sections C13: skin and nipple D. LEFT BREAST  Received fresh labeled with the patient's identification and "left breast" is an oriented 359-g, 15 x 13.5 x 3 cm  mastectomy with 9.5 x 3.7 cm skin ellipse and 1.4 cm everted nipple. Ink code: Anterior/superior-blue,  anterior/inferior-orange, posterior-black. Specimen is serially sectioned into 11 slices from lateral to medial with nipple in slice 5 revealing 3 lesions: 1) 4 x 3.5 x 3 cm firm stellate mass in the upper inner quadrant slices 6-9 that is closest to the anterior margin at 1.1- cm. 2) 1.5 x 1.2 x 1 cm firm nodule in the upper outer quadrant in slice 1 which is 0.8 cm from the deep margin and 5.7 cm lateral to lesion #1 3) 1.4 x 1.2 x 1.1 cm nodule in the lower outer quadrant in slice 1 which is less than 0.1-cm from the anterior margin and 1.6 cm inferior to lesion #2 Tissue is procured. Representatively submitted: D1: slice 1, upper outer quadrant (nodule 2) D2: slice 1, tissue connecting nodule 1 to nodule 2 D3: slice 1, lower outer quadrant (nodule 3) D4: slice 2, posterior mid D5: slice 3, mid section D6: slice 4, mid section D7: slice 5, mid section posterior to nipple.
+
+--- Page 2 ---
+D8: slice 6, section (mass). D9: slice 7, mass and posterior margin D10-D13: mass including margins, en bloc D14: slice 9, mass D15: slice 10, medial to mass  D16: slice 6, upper outer quadrant D17: slice 3, lower outer quadrant D18: slice 4, upper outer quadrant D19-D20: perpendicular sections of nipple and skin. E. LEFT AXILLARY CONTENTS  Received fresh labeled with the patient's identification and "left axillary contents" is an aggregate of yellow-tan soft tissue, 7 x 5 x 2.2 cm. Multiple lymph nodes are identified with firm pink-tan cut surfaces. Lymph nodes are submitted entirely. E1-E2: 6 lymph nodes each E3-E8: 1lymph node each E9-E10: 1 lymph node, bisected E11-E12: 1 lymph node, bisected DIAGNOSIS: A. LYMPH NODE, SENTINEL #1, LEFT AXILLA, EXCISION: - METASTATIC CARCINOMA TO ONE OF ONE LYMPH NODE (1/1), MEASURING 0.8-CM WITH NO EXTRANODAL EXTENSION. B. LYMPH NODE, SENTINEL #1, RIGHT AXILLA, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1). C. BREAST, RIGHT, MASTECTOMY: - MULTIPLE FOCI OF LOBULAR CARCINOMA IN SITU - FLAT EPITHELIA ATYPIA AND ATYPICAL DUCTAL HYPERPLASIA - BIOPSY SITE CHANGES WITH FIBROSIS - MULTIPLE RADIAL SCARS, FIBROCYSTIC CHANGES WITH FIBROSIS, COMPLEX SCLEROSING ADENOSES AND APOCRINE METAPLASIA, AND MICROCALCIFICATIONS IN DUCTAL EPITHELIUM, NO DCIS OR INVASIVE CARCINOMA IDENTIFIED - SEE NOTE D. BREAST, LEFT, MASTECTOMY: - MULTIPLE FOCI OF INVASIVE DUCTAL CARCINOMA, SBR GRADE 2, LARGEST FOCUS MEASURING 4.0-CM - INTERMEDIATE NUCLEAR GRADE, DUCTAL CARCINOMA IN SITU, SOLID AND CRIBRIFORM TYPES WITH CENTRAL NECROSIS AND MICROCALCIFICATIONS - INVASIVE TUMOR PRESENT AT ANTERIOR INFERIOR SURGICAL RESECTION MARGIN - BIOPSY SITE CHANGES WITH FIBROSIS - SEE SYNOPTIC REPORT. E. LYMPH NODES, LEFT AXILLARY CONTENTS, AXILLARY DISSECTION: - METASTATIC CARCINOMA TO TWELVE OF EIGHTEEN LYMPH NODES (12/18), LARGEST MEASURING 2.2 CM WITH EXTRANODAL EXTENSION NOTE: E-Cadherin is positive in the ADH focus and negative in the LCIS Drs. and concur on presence of ADH in the right breast.. SYNOPTIC REPORT - BREAST Specimens Involved Specimens:  A: LEFT AXILLARY NON SLN #1 D: LEFT BREAST E: LEFT AXILLARY CONTENTS Specimen Type: Mastectomy Needle Localization:  No Laterality:  Left  Invasive Tumor: Present Multifocality: Yes WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Tumor size:  4cm Margins:  Involved at Anterior-inferior Extent:: 1-cm
+
+--- Page 3 ---
+Tubular Score: 3 Nuclear Grade: 2 Mitotic Score: 1 Modified Scarff Bloom Richardson Grade: Necrosis: Absent Vascular/Lymphatic Invasion: Present Extent: extensive Lobular neoplasia: LCIS Lymph nodes: Sentinel lymph node and axillary dissection. Lymph node status:  Positive 13 / 19 Extranodal extension DCIS present Margins uninvolved by DCIS DCIS Quantity:Estimate 10% DCIS Type: Solid Cribriform DCIS Location:Associated with invasive tumor Nuclear grade: Intermediate Necrosis: Present ER/PR/HER2 Results ER: Positive PR: Positive HER2: Negative by FISH Performed on Case: Pathological staging (pTN): pT 2 N 3a CLINICAL HISTORY:  None given  PRE-OPERATIVE DIAGNOSIS: Left breast cancer ADDENDUM:  Specimen A was incorrectly designated in the diagnosis field as "LYMPH NODE, SENTINEL #1, LEFT AXILLA EXCISION"; the correct designation of the specimen is "LYMPH NODE, NON-SENTINEL #1, LEFT AXILLA, ExCisiON." Only the specimen description is changed, the diagnosis remains the same.. Microscopic/Diagnostic Dictation: Pathologist, Final Review: Pathologist, Final: Pathologist, Addendum Review: Pathologist, Addendum Final: Pathologist, MtoHtic Axi1lary Lypk nod l 3/s/!4 me
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diff --git a/output/text/7c7e68cb-5be9-48af-8159-46974e3a22be.txt b/output/text/7c7e68cb-5be9-48af-8159-46974e3a22be.txt
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+ICD-6-3 'arsenumg, yoapul esuy renal 8$6o13 Operative Procedure: ee Q l  Nephrectomy 649 Pre-Operative Diagnosis: yJ 3l3[r) Renal mass. Specimen Received:  UUID: 3FF6A88A-8F78-4733-A980-64F07248700C A: Left kidney Redacted B: Peri-aortic lymph node Final Pathologic Diagnosis: A. Kidney, left, nephrectomy: Tumor histologic type: Papillary renal cell carcinoma, type 1. (Please, see note) Sarcomatoid features (%): 0% Tumor size: 5 cm (greatest dimension) Other dimensions 3 x 2 cm Macroscopic extent of tumor: Tumor limited to the kidney Focality: Unifocal Fuhrman grade: 1 0f 4 Microscopic extent of tumor: Perinephric fat invasion: No Renal sinus invasion:  No Renal vein involvement: No Adrenal gland present: No Cancer at resection margin: No Pathologic findings in nonneoplastic kidney:. Patchy chronic inflammation Hilar lymph nodes present: Yes Number involved/number present: 0/1 Ancillary Studies: Racemase: Positive Carbonic anhydrase: Positive TFE3: Negative Vimentin: Positive SDHB: Negative Cytokeratin 7: Positive All controls stained appropriately. Pathologic stage (2010) pT1b, pN0, pMX B. Lymph nodes, periaortic, resection: Fifteen lymph nodes, negative for malignancy (0/15). The examination of this case material and the preparation of this report were performed by the staff pathologist.
+
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+Note: The tumor is predominantly papillary in architecture with cells that mainly have an abundant cytoplasm that ranges from completely eosinophilic to clear. Although, the morphologic features in general are in favor of papillary renal cell carcinoma type I, the cytological features of "clear cells" are concerning for clear cell papillary renal cell carcinoma. Immunohistochemical studies showed that the tumor cells are positive for cytokeratin 7, racemase, carbonic. anhydrase and vimentin and are negative for TFE3 and SDHB. Controls stained. appropriately. The immunohistochemical profile and morphologic features are consistent with the diagnosis of renal papillary carcinoma type I. Dr.  has reviewed the case and concurs with the diagnosis. Gross Description: Received are two formalin filled containers, each labeled with the patient's name Part A Specimen components and dimensions: The specimen is the product of a left nephrectomy, having aggregate dimensions of 15 x 11 x 10 cm and consists of a kidney having dimensions of 10 x 7 x 5 cm, ureter with length of 5 cm. Adrenal gland is not present. Size, appearance, and location of tumor: 5 x 3 x 2 cm located in the mid/superior pole, well encapsulated, inside the capsule the tumor is a friable tissue, yellow tan- to grey tan in color. It is contained within the kidney parenchyma boundaries. Renal capsule/renal sinus: The renal capsule strips with ease. Renal vein: The renal vein is free of tumor. Lymph nodes (size, number, & location): Perihilar fibrofatty tissue weighs 100 grams, it was placed in a fat clearing agent for 30 minutes. Serial sectioning and palpation does not reveal any obvious lymph nodes. Portions of fibrous fatty tissue with probable lymph nodes are submitted in cassettes A13-14 for microscopic analysis. Other findings: Multiple cortical cysts that measure from 0.5 cm up to 2 cm in greatest dimension. Blocks submitted: A1 ureter and vascular margins; A2-4 tumor to renal capsule; A5-6 tumor to renal sinus fat; A7 tumor to collecting system; A8 tumor; A9-12 representative sections of the cysts; A13-14  Perihilar fibrofatty tissue with possible whole lymph nodes Part B is additionally labeled "periaortic lymph nodes" and consists of multiple portions of fibrofatty tissue that measure in aggregate 3 x 3 x 0.8 cm. Sectioning reveals four possible lymph nodes that range from 0.5 cm up to 2 cm in greatest dimension.
+
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+Blocks submitted: B1-2 multiple whole lymph nodes; B3 one lymph node bisected; B4  one lymph node bisected;  one lymph node bisected. Microscopic Description: The final diagnosis of each specimen incorporates the microscopic examination findings. END OF REPORT Surgica! Pathology Report Taken DOB: Gender: F lw 12///13
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diff --git a/output/text/7ca948f8-2e6e-4319-b3c2-e5783725c302.txt b/output/text/7ca948f8-2e6e-4319-b3c2-e5783725c302.txt
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index 0000000000000000000000000000000000000000..e659e2bb77c25d0d29061736572987425d0ec0c5
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+page 1 / 1 CGA-D5-6535 Examination: Histopathological examination Material: Partial organ resection - colon ascending Material collected on: Material received on Expected time of examination: Clinical diagnosis: Examination performed on: Macroscopic description: A 15.6 cm length of large intestine with perintestinal fat tissue sized 16.3 x 8.4 x 3.3 cm and appendix of 5cm. Ulcerous tumour sized 6.3 x 6.2 x 2.8 cm in the mucosa. Tumor covers 100% of the circumference of the intestine and narrows its lumen. Microscopic description: Adenocarcinoma tubulopapillare (G2). Tubulopapillar adenocarcinoma (G2) Infiltratio carcinomatosa telae adiposae pericolicae. Incision lines free of neoplastic lesions. Outside the tumor: Adenomata tubulopapillaria cum dysplasia gradus minoris Metastases carcinomatosae in lymphonodo No 1/VI. Cancer metastases in lymph nodes No I/V! Emboliae carcinomatosae Histopathological diagnosis Adenocarcinoma tubulopapillare coli. Tubulopapillar adenocarcinoma of the colon (G2, Dukes C, Astler - Coller C2, pT3, pN1)
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diff --git a/output/text/7ce664c3-48f5-45ef-95a6-dbaad8bd6c2f.txt b/output/text/7ce664c3-48f5-45ef-95a6-dbaad8bd6c2f.txt
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index 0000000000000000000000000000000000000000..1b8f61e09a0b2feacb363191dd49daeec7670ed6
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+1c5 -0 - 3 8500/3 13/14110 Circenomn, bnfierrating duct, Nos Patient history: St Cod: brst, NoS * DATE of LMP: * C50.9 DATE OF LAST DELIVERY: PRE-OP DIAGNOSIS: STAGE IV RIGHT BREAST CANCER POST-OP DIAGNOSIS: SAME OPERATIVE PROCEDURE: MODIFIED RADICAL RIGHT MASTECTOMY CLINICAL HISTORY: MATERIAL SUEMITTED: RIGHT (MOD) RADICAL MASTECTOMY, PROCUREMENT BY SURGICAL PROCEDURE ADDeNDA: Addendum MATERIAL sUmuTTED: MWH Slide tor ER/PR and Her-2/Neu. FINAL DIAGNOSIS: My signature is attestation that I have personally reviewed the submitted material(s) and the final diagnosis reflects that evaluation.. ER/PR IMMUNOPEROXIDASE IDENTIFICATION OF ESTROGEN AND PROGESTERONE RECEPTORS IS CARRIED OUT ON SLIDE "A4". DISTINCT INTRANUCLEAR STAINING IS IDENTIFIED FOR ESTROGEN RECEPTOR (SOt) AND ALSO TOR PROGESTERONE RECEPTOR (404). THEREFORE, BOTH ARE INTERPRETED AS POSITIVE. HER-2/NEU C-arbB2~ (HER-2/NEU) IMWNOSTAINING IS CARRIED OUT ON USING A 1:3OO DILUTION OF DAXO'S POLYCLONAL ANTIBODY A485 (DIRRCTED AGAINST THE INTRACELLULAR DOMAIN OF c- BLOCK "A4" (BREAST CANCER) erbB2) WITHOUT ANTIGEN RETRIEVAL. NO DISTINCT CCMPLETE MEMBRANE STAINING IS IDENTIFIED. THEREFORE, C-erbB2 (HER-2/NEU) IS INTERPRETED AS NEGATIVE (SCORE O). FINAL DIAGNOSIS: RIGHT BREAST MODIFIED RADICAL MASTECTOMY: 9NOTE - NOTTINGHAM SCORE 8/9 (TUBULES 3, NUCLEAR ATYPIA 3, MITOTIC INDEX 2)  TUMOR EXTENDS TO INVOLVE NIPPLE AND EPIDERMIS OF OVERLYING ULCERATED SKIN INTRADUCTAL CARCINOMA, COMEDO-TYPE, " INVOLVES <5S OF TOTAL TOMOR MARGINS OF RESECTION ARE NEGATIVE FOR TUMOR - MULTIPLE MATTED LYMPH NODES WITH NEARLY CONPLETE ARCHITECTURAL RFFACEMENT BY METASTATIC CARCINOMA (SEE NOTE) NOTE: ER/pR immunoperoxidase assay and Her-2/Neu testing will bo performed on block "At". A prior HER-2/NzU immunost xas performed on a paraffin block received from Shadyside Hospital and was interpretad as negative . Due to possible differences in fixation among institutions, the HER- 2/Neu' study will be repeated on ths present apecimen. The axillary lymph nodes are ertensively matted, indicative of extracapsular extension by tumor. For this reason, an accurate lymph node count cannot be made. UUID:589BC4DD-0079-4106-A2E6-9A48E9BD7DE2 TCGA-BH-A18-01A-PR Redacted
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diff --git a/output/text/7cfc1620-3db4-4aa2-bffc-61ced2bc8e77.txt b/output/text/7cfc1620-3db4-4aa2-bffc-61ced2bc8e77.txt
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index 0000000000000000000000000000000000000000..8240cc17bc2cacbbd154b0b77f4c693fb44e7929
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+TCGA-A3-3351 INEORMAHONAANAHAN SHYSICIANINFORMATIONCAMASMWARNS SEATEN ARN ef Physician. MOWMWT AAASPECIMENINFORMATIONADLR Collected Accession # : Received: Acct / Reg #: Reported W RAR SURGICAL PATHOLOGYREPORTWPWWMM DIAGNOSIS: Kidney, right, radical nephrectomy:. Renal cell carcinoma.. Tumor Characteristics: 1 Histologic type: Renal cell carcinoma, clear cell type. 2. Tumor site: Middle and ower poles of right kidney. 3. Tumor size: 8.4 x 7.9 x 3.4 cm. 5. Nuclear grade: Fuhrman grade: 2 of 4. 1 Transcapsuiar invasion: Absent.. 8. 1  Renal vein invasion: Absent.. 9. Venacaval invasion: Venacava not resected.. 10. Adrenal gland: No significant pathology. Surgical Margin Status: 1. Soft tissue margins: No evidence of malignancy. 2. Ureteral margin: No evidence of malignancy. 3. Vascular Margins: No evidence of malignancy. Lymph Node Status: None resected. Other Significant Findings:. 1.The remainder of the kidney demonstrates focal interstitial chronic inflammation.. 2. pTNM stage: pT2 NX MX. Staging Sheet #36. Electronic Signature: PXCLINICALINFORMATIONOWO
+
+--- Page 2 ---
+PATIENTINFORMATIONAOAPSSMPAPR EAPNAPALASRNSARRSRAMREAEUERACRRCLINICALINFORMATION CLINICAL HISTORY: Preoperative Diagnosis: Abdominal mass, unspecific site. Postoperative Diagnosis: Symptoms/Radiologic Findings: SPECIMENS: Right kidney (tissue study) SAOAAESPECIMENDATANRENRSARSYAAARKNRTR GrOSS DESCrIPT!ON: Received in formalin labeled #d #1 right kidney (tissue study) is a 640 gm previously bisected nephrectomy specimen, consisting of a 13.8 x 8.1 x 3.6 cm kidney, with a moderate amount of attached perinephric fat. There is a minimal amount of attached renal vein and artery, and a 5.5 x 0.2 cm segment of ureter at the hilum. The capsule is smooth and tan-gray. The cut surface consists of an 8.4 x 7.9 x 3.4 cm, mottied tan-red to orange-yelow mass invoving the middle and lower poles. The cut surface of the mass consists of cystic, hemorrhagic, red-orange to yellow soft tissue. The mass grossly appears to abut the capsule and is 0.2 cm from the inked deep margin. The mass does not invoive the renal vein margin. The remainder of the cut surface consists of red-brown parenchyma. The corticomedullary junction is well-defined. The urothelium is glistening gray-white. The adrenal gland is present. No obvious lymph nodes are identified. The specimen is inked, serially sectioned, and representative sections are submitted as labeled:  Block 1 - ureteral and vascular margins; blocks 2 and 3 - mass to inked deep margin; block 4 - mass to uninvoived parenchyma; block 5 - mass to capsule; blocks 6 to 8 - mass; block 9 - uninvolved parenchy I 10.. adrenal gland. The blocks are labeled *. Also received in the  same container is a green-yellow and blue cassette labeled Or genomic research study. END.OFREPORT
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diff --git a/output/text/7d0a031c-d7fe-4b10-b784-385abb549a62.txt b/output/text/7d0a031c-d7fe-4b10-b784-385abb549a62.txt
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+Diagnosis: Right hemicolectomy preparation with a poorly differentiated adenosquamous carcinoma in the ascending colon of histopathological differentiation grade G3, with ulceration of the inner surface of the tumor, peritumorous chronic recurrent concomitant inflammation, with carcinomatous lymphangitis, tumor infiltration in the parietal layers of the colon as far as the pericolic fatty connective tissue, with moderately chronic lymphadenitis of the tumor- free lymph nodes (0/12), chronic appendicitis and with tumor-free overview slices from the resection margins, from the region of the vessel ligature and from the adjoining omental fatty tissue. According to the sections examined, the tumor spreading from the colon carcinoma. corresponds a tumor stage of pT3, pN0, MX, L1, R0.
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diff --git a/output/text/7d0d55a2-5060-44a6-b623-a60f065b0231.txt b/output/text/7d0d55a2-5060-44a6-b623-a60f065b0231.txt
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index 0000000000000000000000000000000000000000..b3c7edc50bb7280cdb1a9f699d45176bc075cb6d
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+UUID:5F714C34-BB01-49D1-B41C-C64DE8D0EC0E teD o-3 TCGA-DD-AAVS-01A-PR Redacted Chrcinomo, hepstreellelor 8170/3 Sut sluir CQQ.0 DIAGNOSIS: Liver. right. heminepatectomy:. A4u H|a3|J4 Hepatocel lular carcinoma 1) Post-chemoembol ization status: absent 2) Size of tumor: 10.5x8.0x7.5cm 3) Gross type: nodular with per inodal extens on 4) Satellite noduie: absent 5) Histologic lype: trabecular and pseudoglanda ar 6) Cel! type: classic and clear 7) Edmondson and Steiner's histoiog'c grade. The woist ditferentiat ion: 3 The major difierentiation: 2 8) Fatty change: absent 9) Hemoi rhage/pel osis: absent 10) Tumor necrosis: absent 11) Vascular invasion(microscopic): absent 12) Capsule format lon: partial 13) Intiltration of capsule: present 14) Septal formation: present 15) Invoivement ol a ma oi branch ot the porta' vein: absent 16) Involvement ot a major branch of the hepatic ve.n: absent 17) Bile duct invasion: absent 18) Serosal invasion: absent 19) Surgical margin: clear resection margin (satety ma: gin: 0.5cm) 20) Int anepatic metastasis: absent 21) Muiticentric occuirence: absent 22) Patnologic stage: AJCc (p!1) (pr2) 23) Pelated biopsy: none 24) Additiona! pathologic findings a) Chronic nepatitis. HBv associated with minimal iobular activity moderate porto-per iportal activity portai fibrosis b) Cirrhosis: absent c) Dysplasia: absent Galibladder. cholecyslectomy : Chronic cholecyst itis with cholestro! polyp M y7|4
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diff --git a/output/text/7d31a9fd-ee6f-4539-aae7-8fc32fa72bcd.txt b/output/text/7d31a9fd-ee6f-4539-aae7-8fc32fa72bcd.txt
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+UUID:6B1308E3-4C23-43B7-9608-1EA6D435525D0 TCgA-CF-A9FF-01A-PR Redacted Clinical Case Report z0D-0.3 blirsthlil: S43015 8/3013 Informed Consent Sute . Ydiuldir, lileuk uxll I personally informed this patient that a specimen(s) would be collected to be used for research Ce7.2 purposes. I reviewed the RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator wignature Date Clinical Information. GENERALINFORMATION Date of Birth (mm/dd/yyyy) Height  Marital Status Race Temperature  SinglepoMarried Gender Weight  Divorced  Widow  Blood Pressure Heart Rate TMale  Female P  Chief Complaints: L-oWe abdomu!nal Symptoms: Weight toss . Clinical Findings: Performance Scale (Karnofsky Score):  100 Asymptomatic  80-90 Symptomatic but Fully Ambulatory  /60-70 Symptomatic, in bed less than 50% of day  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden  20-30 Bed Ridden CURRENT MEDICATIONS Drug Dose Route Frequency Date (mm/dd/yyyy) To / To 1 / To To To /
+
+--- Page 2 ---
+. PASTMEDICALHISTORY  Diagnosis/Disease/Disorder/Injury Diagnosis Date Treatment Status BWWMSOBGYNHISTORYRLWRR Menopausal Status Date of First Menses # of Pregnancies  Pre-menopausal  Peri-Menopausal Date of Last Menses # of Live Births  Post-menopausal Birth Control:  Condom Oral Contraceptive IUD  Hormone Replacement  Other: Therapy: ESOCIALHISTORYAWMMMS Occupation: Environmental Hazards: ! Smoking History Current Status TyPE  Packs/day Duration When Quit  YES  NO (yrs) (yr) Alcohol Consumption Current Status TYPE  Drinks/day Duration When Quit YES  nO Sdhinb Tdeuy (yrs) (yr) Drug Use Current Status TYPE Frequency Duration When Quit 1  YES NO (yrs (yr) Relative  Diagnosis Age of Diagnosis ATLABDATA Test Result Date Test Result Negative Date HIV  Positive:  CEA  Negative  Positive: Hep B Negative  Positive: CA 15-3   Negative '  Positive: Hep C ePNegative  Positive: CA 19-9   Negative  Positive: AFP   Negative  Positive: PSA   Negative  Positive: Other:  Negative  Positive: Other: Negative Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+B DIAGNOSTICSTUDIES.WOROS Study Results Date Ultrasound . A tisanwocsk Was fouel issthe I2. blodde X-Ray CT Endoscopy MRI Biopsy CLINICALDIAGNOSIS Preoperative Clinical Diagnosis Location of Suspected Involved Lymph Nodes Location of Suspected Distant Metastasis Clinical Staging Date of Diagnosis TZNO MO Stage: Treatment Information Procedure Date of Procedure Reseeticn de Primary Tumor Organ Detailed Location Size blatder Jatewell pj blecleled 2 x 2 xj<cm Extension of Tumor M Lymph Nodes Description Location of Lymph Nodes # of Lymph Nodes Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Organ  Detailed Location Size Surgical Staging No. mO Stage: NEOADJUVENT THERAPY(Chemo RadiationImmuno HormonalorMolecular Drug/Treatment Dose Route Frequency Date (mm/dd/yyyy) 1 To / / To To To To 3
+
+--- Page 4 ---
+Pathology Form Specimen Information. Collected by: Date: Time: Preserved by: Date:  Time:_ wa.wSPECIMENTYPE #ofsamples providedww. Frozen Paraffin Block Blood/Serum/Plasma Slide Diseased Normal Diseased Normal Diseased Normal Diseased  Normal 2 2 2 Time to LN2 Time to Formalin Time to LN2 min AA min min . CURSRRPATHOLOGICALDESCRIPTIONADRANE Primary Tumor Organ Size Extension of Tumor. Distance to NAT hladle lumeR 2 x 2 xscmLaTewal oL heWe/8R :cm Lymph Nodes Location # Examined # Metastasized Distant Metastasis. Organ Detailed Location Size Pathological Staging. m 0 Stage:  pT 2 NU Notes: : 4
+
+--- Page 5 ---
+Consolidated Pathology Diagnosis ID#: Cell Distribution + - Sructural Pattern Diffuse Y.  Streaming Mosaic  Stortform Necrosis Fbrosis Lmohocytic Infitration Palisadino Vascutar Invasion Crstic Deceneration Custerized Bleeding. Alveolar Formation x1 M zxoid Change Indian File X Psanmoma/Caicincation 1 Sessn mous +- Adenomatous + I- Sarcomatoue Squarnoid Cel! Glandutar cell Lymphomatous Round Celj +I. Spindle Cell Laroe Cell Cel Stratnication Fibrobiast Keratin. Small Cel  Secretion Osteoblast Desmosome.  RS Cell/RS Like Intracyt. Yacuole Lipobiast Pearl Inflarn. Cel! Gtand formation Myoblast Plesma Cell Cellular Differentiation:  Well gModerate  Poor a Nucieer At ypia: Aniso Nuceosis. 0 I m Htyperchwromatism Nucieoiar Prominent Muttinucleated Giont Cell Mitotic Activity Nudiear Grade: Fina! Pathology Report PD/asy ToQssi Kto4lGnde: !* Histological Diagnosis: Comments: Dlrector, Research Pathology Date lw i/3f!y INTEGRATED REPORT OF FINDINGS BY COLLABORATORS AND PATHOLOGISTS -- Criteria V IPAA Discrepanc rior Malignancy History al/Synch Case is clr QUALIFIED DISQUAFI5 213c113 s
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diff --git a/output/text/7d8b9e55-6457-4638-b6c1-c3f237ca061c.txt b/output/text/7d8b9e55-6457-4638-b6c1-c3f237ca061c.txt
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+FINAL DIAGNOSIS: Collection Dute: PArt 1: BReaSt, LEFt, SKIN SPEaRing PROphyLaCTIC tOTAl MAStecTOMY -- FIBROCYSTIC CHANGES. A B. COLUMNAR CELL CHANGES. UUID: B2328EE4-8579-4E26-B45C-8A5BFC0CEDBD c. SCLEROSing ADenOSiS. TCgA-Bh-A2L8-01A-pR Redacted D.  PSEUDOAnGIOMATOUS STROmAL HyPERPLASIA E. Ductal epithelal hyperplasia. *:  NIPPLE AND SKIN. Part 2 sreaSt, RISHI:Skin SpEaring TOtal mAstectOmy -  InVASiVe LOBuLAr CArcInOmA, cLASSic TypE, twO fOC!, 3 Cm (uPPEr and LOWEr ouTEr qUADRANtS) AnD 4.2 CM (UPPER OUTER QUADRANT) (GROSS), NOTTiNGHAm GRADE 2/3 (COmBiNED NOTTINGhAM SCORE 6/9: TuBULe FORmATION- 3/3, NUCleAR ATYPIA 2/3, miTOTC AcTiViTy 1/3)). B. LoBuLAR CarcinOma in SItU (Lcis), nUclear gRaDe 2, cLAssicaL TyPe wiTh cOmeDO nEcrOSiS. C.  NO LYMPHOVASCULAR iNVASION. D.  MArGiNs FreE, inVASIVE CaRcinOmA WiThIN LESs ThAn 1 mm FrOm ANTeRIOr MArGiN. E. Fierocystic changes. F.  COLUMNAR CELL CHANGES AND HYPERPLASIA G. FiBroadenomatoid changes. H.  PSEUDOANGIOMATOUS STROMAL HYPERPLASIA (PASH). MICROSCOPIC RADIAL SCAR. J. Biopsy site changes x 2 K. NIPPLE AND SKIN Er/pR- POsiTiVe, hER-2 - 2+, wIThOut AmpLiFicATIOn By FiSh Part 3: senTinel node, Right axilla, Biopsy -  One Lymph node, negative fOr metastatic Carcinoma (0/1). Part 4: breast skin, Right, excision - A. BenIgn BreaSt PIParenchymA. B.  Skin anD subcutaneous tissue. Part 5: BreaSt SKin, Left, ExcIsiOn - SKIN AND SUBCUTANEOUS TISSUE. COMMENT: Negative status of the lymph node was confirmed by cytokeratin immunostain. CASE SYNOPSIS: SYNOPTIC-PRIMARY INVASIVE CARCINOMA OF BREAST LAtErALITy: Right PROCEOURE: Simple mastectomy LOCATION: Upper outer quadrant Lower outer quadrant SIZE OF TUMOR: Maximum dimenslon invasive component: 42 mm MULTICENTRICITYAMULTIFOCALITY OF iNVASIVE FOCI: No TUMOR AGGREGATE SIZE: Sum of the sizes of muitiple invasive tumors: 72 rnm TUMOR TYPE (invasIve component):  Infitrating lobular carcinoma HISTOLOGIC TYPE: Classical NOTTINGHAM SCORE: Nuclear grade: 2 Tubule formation: 3 Mitotic activity score: 1 Total Nottinghan score: 6 Nottingham grade (1. 2, 3): 2 ANGIOLYMPHATC INVASION: No DERMAL LYMPHATIC INVASION:  No CALCIFICATION: No Tumor type, in situ: LCIS SUrgICAL mArGIns inVOLVED By InVASiVE COMPONENt: No SURG MARGINS INVOLVED BY IN SITU COMPONENT: No ics-0-3 PAGET'S DISEASE OF NIPPLE: No LYMPH NODES POSITIVE: LYMPH NODES EXAMINED: 1 Carcioma, ni fiHnsting 1obulw, Nos METHOD(S) OF LYMPH NODE EXAMINATION: 8570/3 H/E stain, Keratin stain T STAGE, PATHOLOGIC:  pT2 Sitx: breust, Nos c50.9 N STAGE MODIFIER: (sn) N STAgE, PATHOLOGIC:  pNO M StaGe: Not applicable EsTrOgen RECeptOrS: positive, previously performed, H-score: 295 8/18/1 PROGESTERONE RECEPTORS: positive, previously performed, H-score: 275 HER2/NEU: 2+ HER2/NEU (FISH): Not amplified
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diff --git a/output/text/7d9cedde-14ba-4603-9d1e-8b4040fb16ad.txt b/output/text/7d9cedde-14ba-4603-9d1e-8b4040fb16ad.txt
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index 0000000000000000000000000000000000000000..9c511dc12916f383bd2285d5e0fae6d6668e4f19
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+DO3 derdronLumo , gade II 945013 C Beroun, Syeatentorol NoS C71D Anatomic Pathology/Cytology Document State: (version ) Rrsir , occpitol. lobe C71 4 Update Date/Time: Final 1 S J4/Qq|1y Patient Name: MRN: Service Date/Time: DOB/Age/Gender: Male Provider: Location: Responsible Staff UUID:4E9DD63D-7C18-4922-9385-37B0BB2CCB8F tcgA-Du-A7Ta-01A-Pr Redacted Accession #: Phone Number: client: Location: Taken: Received: Reported: Physician(s): Phy Location: CLINICAL HISTORY -year-old man with left sided blurred vision and papilledema has a. large right occipital, non enhancing brain tumor. OPERATIVE DIAGNOSES Not Given Operation/Specimen: A: Brain, excision biopsy B: Brain, excision biopsy PATHOLOGICAL DIAGNOSIS: A. Brain biopsy: Oligodendroglioma, proliferation index ( MIb-1 ) : 2% COMMENT Sections show an oligodendroglioma with a loose, microcystic background. The cellularity is moderate with mild nuclear pleomorphism. There are many minigemistocytes. Mitotic figure is not seen. There is no vascular hyperplasia. or necrosis. **Electronically Signed Out*** ., Senior Staff Pathologist INTRA-OPERATIVE CONSULTATION Brain, occipital, biopsy: Glioma (possibly astrocytoma, cannot R/o oligo)..  Senior Staff Pathologist GROSS DESCRIPTION A. Received fresh, three fragments, 0.8 cm. in aggregate. Semi firm, yellowish-grey, glistening. In total, Al and A2. B SPECIMEN: Brain tumor. FIXATIVE: None. GENErAL: Received are two tan-gray rubbery portions of tissue measuring 3.5 x 3 x 1 cm and 3 x 1.5 x 1 cm. SEcTions: Representative sections in 3 cassettes with reps in the larger portion A1 and A2, smaller portion in B3. , Senior Staff Pathologist ICD-9(s) : 191.4 191.4 Billing Fee Code(s):. A: B: Histo Data Part A: Brain, excision biopsy Taken: Received: Stain/cnt Block Ordered Comment
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+H/E x 1 1 MIB1-DA x 1 1 H/E x 1 2 Part B: Brain, excision biopsy Taken: Received: Stain/cnt Block Ordered Comment H/E x 1 1 H/E x 1 2 H/E x 1 3 MIB1-DA x 1 3 *** End of Report.
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+UUID:0B86CAC8-CE26-461F-A9FE-46E28E96A368 Laboratory TCGA-EW-A423-01A-PR Redacted Name: XXXX Case #: xxxx Collected: xx Gender: F Received: xx MRN: xXX Reported: xx Location: xXX Copy To: Physician: XXX Pathologic Interpretation: A. LEft BREAST nEEDLE LOCALiZATION LUMPECTOMy: INVASIVE LOBULAR CARCINOMA with pleomorphic features, Nottingham grade 2 (3+2+2=7), measuring 2 cm. PLEOMORPHIC LO8ULAR CARCINOMA IN SITU is present. Prior biopsy site present.  The invasive carcinoma is 0.1 cm from inferior and lateral margins (green, orange). B. hot spot #1, AxIllA I, CT-xxx: icd-o-3 One lymph node, negative for carcinoma (0/1) CArCim0rTa,lnF1ha+ nq,10bukr,Nos C. hOT SpOt #1, AXIlLA1 CT -xxx: g520[3 Sik: bregst,nO5 One lymph node, negative for carcinoma (0/1). C6,9 Note: Receptor studies and keratin stains to follow. See Tumor Summary. 7-24-12 20 Surgical Pathology Cancer Case Summary Procedure: Excision with wire-guided localization Lymph Node Sampling: Sentinel lymph nodes Specimen Integrity: Single intact specimen (margins can be evaluated) Specimen Size (for excisions less than total mastectomy): Greatest dimension: 5 cm Additional dimensions: 4.5 x 3.5 cm Specimen Laterality: Left Tumor Size: Size of Largest Invasive Carcinoma: Greatest dimension of largest focus of invasion: 2 cm Tumor Focality: Single focus of invasive carcinoma Macroscopic and Microscopic Extent of Tumor: Skin: Skin is not present Skeletal Muscle: No skeletal muscle present Ductal Carcinoma in Situ (DCIS): No DCIS is present Lobular Carcinoma in Situ (LCiS): Present (pleomorphic type) Histologic Type of Invasive Carcinoma: Invasive lobular carcinoma (pleomorphic type) Histologic Grade: Nottingham Histologic Score: Glandular (Acinar)/Tubular Differentiation  Score 3: < 10% of tumor area forming glandular/tubular structures Nuclear Pleomorphism
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+Score 2: Cells larger than normal with open vesicular nuclei, visible nucleoli, and moderate.  variability in both size and shape Mitotic Count: Score 2 Overall Grade: Grade 2 Margins:  Margins uninvolved by invasive carcinoma. Distance from closest margin: 1 mm Distance from superior margin: > 5 mm Distance from inferior margin: 1 mm Distance from anterior margin: > 5 mm Distance from posterior margin: > 5 mm Distance from medial margin: 4 mm Distance from lateral margin: 1 mm Treatment Effect: Response to Presurgical (Neoadjuvant) Therapy: In the Breast: No known presurgical therapy Lymph-Vascular Invasion: Not identified. Lymph Nodes: Number of sentinel lymph nodes examined: 2. Total number of lymph nodes examined (sentinel and nonsentinel): 2 Number of lymph nodes with macrometastases (> 0.2 cm): 0 Number of lymph nodes with micrometastases (> 0.2 mm to 0.2 cm and/or > 200 cells): 0 Number of lymph nodes with isolated tumor cells (s 0.2 mm and  200 cells): 0 Method of Evaluation of Sentinel Lymph Nodes:  Hematoxylin and eosin (H&E), one level Pathologic Staging (pTNM): Primary Tumor (pT): pT2: Tumor > 20 mm but  50 mm in greatest dimension. Regional Lymph Nodes (pN):  pNO: No regional lymph node metastasis identified histologically Distant Metastasis (pM): Not applicable Ancillary Studies (performed on another specimen: xxxx): Estrogen Receptor: POSITIVE (> 50%) Progesterone Receptor:  NEGATIvE (less than 1% immunoreactive cells present) HER2/neu Immunoperoxidase Studies: NEGATIVE (CISH: NOT AMPLIFIED) ***Electronically Signed Out By*** NOTE: Some immunohistochemical antibodies are :  analyte specific reagents (ASRs) validated by our laboratory (Her 2, Parvo, H. pylori, HBcore). These ASRs are clinically. useful indicators that do not require FDA approval. These clones are used: ID5=ER, PgR 636=PR, A485=HER2, H-11=EGFR, CCH2/DDG9=CMV, F39.4.1=AR and HPV by ISH. All immunohistochemical stains are used with formalin or molecular fixed. paraffin embedded tissue. Detection is by LSAB. The results are read by a pathologist as positive. or negative. XXX Procedures/Addenda Addendum Date Ordered: xx Status: Signed Out Date Complete: xx Date Reported: xx Addendum Diagnosis A. LEft brEaSt NEedLe LOCALIZAtIon LumpecTOMY: Immunohistochemical studies were performed on formalin fixed tissue with the following results for [invasive. carcinoma/DCIS/metastatic carcinoma] (block xx): Estrogen receptor
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+ID5 POSITIVE (> 90%)  Progesterone receptor PgR 636 POSITIVE (1 -10 %) HER-2/neu (c-erb-B2) NEGATIVE 0 B. hOt SpOt #1, AXiLLA i, CT-xx: Immunohistochemical studies were performed on formalin fixed tissue with the following results for metastatic carcinoma (block B): Keratin: NEGATIVE (see note). Note: A single cell that appears to be keratin positive is present in the subcapsular space. However, the nuclear size  and morphology of this cell is different than the primary tumor cells. Selected slides were reviewed with Dr. XX and concurs with the diagnosis. C. hOt SpOT #1, AXILLA I CT -xx: Immunohistochemical studies were performed on formalin fixed tissue with the following results for metastatic carcinoma (C): Keratin: NEGATIVE. Interpretation Guidelines: For hormone receptor immunohistochemical analysis, the percent of immunoreactive  nuclei in the invasive or in-situ carcinoma is assessed manually by light microscopic examination and reported as follows: Positive: greater than or equal to 1 percent of nuclei immunoreactive Negative: less than 1 percent of nuclei immunoreactive.  Non-neoplastic mammary epithelial cells are immunoreactive for estrogen and progesterone receptors (internal control). For HER2/neu immunohistochemical analysis, the cell membrane staining is assessed manually by light microscopic examination. Cytoplasmic immunoreactivity alone is scored as a negative result.. Reference #1: XX Reference #2: XX Clinical History: Infiltrating lobular cancer in ieft breast. Please evaluate margins of lumpectomy. If sentinel nodes are negative, do immunohistochemistry. Specimen(s) Received/Processing Information: Fee Codes: A: Left breast lumpectomy, 1 suture superficial margin, 2 suture medial, 3 suture. inferior H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1,. H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, Estrogen Receptor (ER) x 1,
+
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+ Progesterone Receptor x 1, CERb82, HER2/neu x 1 B: Hot spot #1, axilla I, CT-356  H&E, Initial x 1, unstained x 1, unstained x 1, unstained x 1, unstained x 1, Desmin 33 x 1 C: Hot spot #1, axilla I CT -473 H&E, Initial x 1, unstained x 1, unstained x 1, unstained x 1, unstained x 1, Cytokeratin Cocktail (KER) x 1 Gross Description:. Received fresh and labeled "Left breast lumpectomy" is a yellow-tan irregular-shaped lumpectomy,  measuring 5.0 x 4.5 x 3.5 cm and weighing 35.0 grams. The specimen is inked as follows: superior margin inked blue, inferior margin inked green, medial margin inked red, lateral margin inked orange, anterior/superficial margin inked yellow and deep margin inked black. Sections reveal an ill-defined area with firm to hard consistency, 2.0 x 2.0 x 1.5 cm. This area is located toward the medial to posterior resection margin at 0.2 to 0.3 cm from the deep resection margin (nearest), 0.3 cm from the inferior resection margin, 3.0 cm from lateral resection margin, 2.0 cm from the superior resection margin, 1.0 cm from the superficial resection margin. The remainder of the specimen is homogeneous, yellow-tan, grossly unremarkable adipose tissue. No other suspicious lesions are present. The specimen is submitted in nine cassettes, as follows: Cassette #1-3: Tissue with clip in toto. Cassette #4: Perpendicular section superior margin Cassette #5: Perpendicular section inferior margin Cassette #6: Perpendicular section medial margin Cassette #7: Perpendicular section lateral margin Cassette #8: Perpendicular section superficial margin Cassette #9: Perpendicular section deep margin B.  Received in formalin and labeled "Hot spot #1, axilla I, ct xx' is a yellow-tan irregular-shaped soft tissue fragment, 3.5 x 3.0 x 1.0 cm. Sections reveal one lymph node, 1.5 x 1.0 x 1.0 cm. The lymph node is bisected and submitted in toto in one cassette. C.  Received in formalin and labeled "Hot spot #1, axilla I, ct xx" is a yellow-tan irregular-shaped soft tissue fragment, 2.8 x2.0 x 1.0 cm. Sections reveal one lymph node, 1.5 x 1.0 x 1.0 cm. the lymph node is bisected and submitted in toto in one cassette. xXX
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index 0000000000000000000000000000000000000000..96c7c44ce1bb77ad63df0de84f8507155edbeedf
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+SUPPLEMENTAL REPORT DIAGNOSIS: LefT hEMIMANDIBLE: Decalcified sections of mandible underlying the carcinoma are negative for tumor. DIAGNOSIS (A)  UPPER AND MID JUGULAR LYMPH NODES: Sixteen lymph nodes, no evidence of metastatic disease.. (b) LEft mAnDIbuLAr NeRVe: Peripheral nerve, no evidence of carcinoma.. (c) TONGUE MARGIN: Squamous mucosa,  skeletal muscle and salivary gland, no evidence of' carcinoma. (D) BUCCAL MARGIN: Squamous mucosa, skeletal muscle and salivary tissue,. no evidence of carcinoma. (e) ANTERIOR TONSILLAR PILLAR MARGIN: Squamous mucosa and salivary gland tissue, no evidence. of carcinoma. (F) TUMOR WITH SUBMANDIBULAR TRIANGLE AND LEFT HEMIMANDIBLE: INVASIVE, WELL DIFFERENTIATED SQUAMOUS CARCINOMA, 3.O X 3.O XE 2.5 cm. PERINEURAL INVASION IDENTIFIED. No lymphovascular invasion identified. Tonsil with reactive follicular.  hyperpTasia. Page 1 of 2 History Case Pathology Report History Case Pathology File under: Pathology
+
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+GROSS DESCRIPTION (A) UPPER AND MID JUGULAR NODES, HEMOSTAT SUPERIOR - A fragment of adipose tissue (5.0 x 2.0 x 1.0 cm) containing sixteen lymph nodes ranging in size. from 0.2 to 1.8 cm. Lymph nodes are serially dissected from superior to inferior and submitted in Al-A12, in order. sEction coDe: A1-A9, A12, single lymph node in each cassette; A10, three small lymph nodes; Al1, three' smalI lymph' nodes. *FS/DX: PERIPHERAL NERVE, NO TUMOR PRESENT. (B) LEFT MANDIBULAR NERVE, HEMOSTAT PROXIMAL -'A str!p of nerVe tiSSue (3.O X inked black and is taken for frozen section en face with the adjacent nerve in Tongitudinal.  The proximal marain is inked d red and the remaining tissue is. totally submitted in b2. (C) TONGUE MARGIN, HEMOSTAT ANTERIOR,S NEW MARGIN INKED - An irregular strip of' tongue tissue (5.0 x 1.5 x 1.0 cm) with hemostat designating anterior. new margin is previously inked by surgeon. The INK code: Anterior-red, posterior-yellow, deep-black, previously inked. section code: c1-c4, new margin en' face for frozen section anterior to posterior; c5-c6, random mucosal section. *FS/DX: NO TUMOR PRESENT. permanent. (D) BUCCAL MUCOSAL MARGIN, HEMOSTAT ANTERIOR - A strip of red-tan muCOsa (4.0 x 1.0 x 1.0 cm) with hemostat designating anterior. INK code: Anterior-red, posterior-yellow, deep-black. SeCTION coDE:  D1-d3 margin, en face, anterior to posterior, for frozen section. *FS/DX: NO TUMOR PRESENT. (E) ANTERIOR TONSILLAR PILLAR MARGIN,S  HEMOSTAT ANTERIOR - A strip of red-tan mucosa (2.5 x 0.5 x 0.5 cm) with a hemostat designating anterior. Ink code: Anterior-red, posterior-yellow, deep-black. section_code: El. E2, margin, en face for frozen section, anterior to posterior. *fs/DX:  NO TUMOR PRESENT. (F) TUMOR HEMIMANDIBLE AND SUBMANDIBULAR TRIANGLE - TumOr and soft tisSue (6.0 x 3.0 x 3.0 cm) with contiguous submandibular triangle (5.0 x 4.0 x 1.0 cm and portion of 1eft hemimandible (composite hemimandibulectomy) (7.0 x 3.0 x 1.0 cm). Overlying mucosa on the soft tissue measures 5.0 x 1.0 cm.. A crescent shape centrally ulcerated tumor is present on the mucosal. surface, it measures 3.0 x 3.0'x 2.5 cm and has pushing borders, but there is no definite invasion into the submandibular triangle.. 'The tumor is white-gray with a vague lobulated appearance..  The margins have been previously examined by frozen section.. Five possible lymph nodes ranging in size from 0.5 to 0.8 cm are dissected.  The portion of mandible is grossly unremarkable. The bone is pending decalcification. secrion coDe: F1-F4, tumor; F5, tumor and contiguous salivary gland tissue: E6-E0 -ingle lymph node in each cassette; F10, one possibTe lymph node. SNOMED CODES M-80703 T-51600 Page 2 of 2 History Case Pathology Report History Case Pathology File under: Pathology
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+UUID:8EE9788C-EF35-44D5-8908-C14B5AFA8FAA TCGA-A4-A48D-01A-PR Redacted Referrina Phvsician: Gender:M Age: DOB: ider Group : ient Date Reported: FINAL SURGICAL PATHOLOGY REPORT Diagnosis: Icd- 0 -3 Carcnoma, Prpillay /nl cll 824of3 RIGht RENAl MASS, ParTIal NEphrECtOMy: - Papillary renal cell carcinoma, type 2. Sife: Kidny,Nos Cb4.9 - Fuhrman nuclear grade 3. - Tumor size: 4.2 cm. 1/3n113 - Tumor limited to kidney. - Surgical margins negative. PATHOLOGIC TUMOR STAGING SYNOPSIS (RIGHT KIDNEY): Type and grade: Papillary renal cell carcinoma, type 2, Fuhrman nuclear grade 3. Primary tumor: pT1b. Regional lymph nodes: pNX. Distant metastasis: N/A. Pathologic stage: I. Lymphovascular invasion: Not identified Margin status: R0, negative. Kidney Tumor Staging Information Data derived from current specimen. Staging in accordance with or modified from AJCC Cancer Staging Handbook, 7th Ed, and CAP protocol, Page 1 Patholoay Cr ne... eport Case #: This report continues... (FinAL) Printed: Patient Page 1 Doc#
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+Patient Case #: Partial nephrectomy. Procedure: Right. Specimen laterality: 4.2 cm. Tumor size: Single focus. Tumor focality: Limited to kidney.. Macroscopic extent of tumor: Papillary renal cell carcinoma, type 2. Histologic type: Not identified. Sarcomatoid features: Fuhrman nuclear grade 3. Histologic grade: Limited to kidney.. Microscopic tumor extension: R0, negative, tumor 0.3 cm from renal parenchymal Margins: margin. N/A. Lymph nodes: Pathologic tumor staging: pT1b. Primary tumor: pNX. Regional lymph nodes: N/A. Distant metastasis: I. Patnologic stage: Mild arteriolonephrosclerosis. Pathologic findings in nan-neoplastic kidney: Page 2 Patholnav Cansultation Report Case #: This report continues... (FinAL.) Printed: age 2 Doc# 1
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+Patient: Case #: FInAL SuRGICAL PATHOLOgy REPORT Source of Specimen:  Mass,right renal mass Clinical History/Operative Dx: Right renal Gross Description: Single specimen designated as right renal mass. Initially received in the fresh state for possible. Oncogenotyping studies is a 50 gram portion of renal tissue, 6.5 x 5.0 x 4.2 cm. The likely deep surgical margin is now marked black. The renal capsular surface includes a discreet amount of Gerota's fascia, and is now over-inked blue. The specimen is serially sectioned to reveal a well-clrcumscribed encapsulated appearing tumor mass measuring upwards of 4.2 cm and demonstrating a predominantly delicate, possibly non viable, deep-red, hemorrhagic cut surface. The mass lesion grossly approaches within 0.3 cm of the nearest surgical margin. The grossly uninvolved renal tissue along the deep surgical margin is dusky red and purple. The tumor  mass appears grossly confined and abuts the renal capsule.. A representative portion of the tumor mass along with *paranormar renal tissue is submitted for. Oncogenotyping studies. Representative sections/portions of the mass lesion are submitted for routine histology in A1 and A2 (wrapped in filter paper) with the renal capsule/Gerota's fascia represented in. A3-A4 and surgical margin and tumor relationship in A5-A8. Microscopic Description: Microscopic sections have been examined. The microscopic findings are retlected in the diagnosis. rendered. office notified of was obtained. An intradepartmental consultation with results on Page 3 Patholonv Consultation Report Case #: END OF REPORT (FINAL) Printed: Patient Page 3 Doc# 1 Mathalany Rennrt - Page 3/3
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+1cs-0-3 Cnucioms, infiHtneHug duct, nos 8500/3 8ife: srast Nos C50.9 4/7/1 h Procurement Date aterality:Right, lower inner quadrant Path RepOrt:BREAST TISSUE CHECKLIST Specimen type: Mastectomy Specimen size: Not specified Tumor site: Breast Tumor size: 2.5 x 2 x 2 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinoma Histologic grade: Moderately differentiated Tumor extent: Not specified Lymph nodes: 2/12 positive for metastasis (Subclavicular 2/12) Extracapsular invasion of the lymph nodes: Not specified. Margins: Not specified Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined. Evidence of neo-adjuvant treatment: Not specified. UUID:B0E8F3C1-E996-4E70-9630-AC95AF6E4EDC Additional pathologic findings: Not specified. TCGA-E9-A228-01A-PR Redacted Comments: None
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diff --git a/output/text/7eb719e2-d7f6-40b7-bc93-f79900dd1af1.txt b/output/text/7eb719e2-d7f6-40b7-bc93-f79900dd1af1.txt
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index 0000000000000000000000000000000000000000..0bf7ff03739cf747bafacc26a3a50488b335a617
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+icD-0-3 Site: breast, nos C5o.q 31 Department of Cancer Pathology copy No. Date: Examination: Histopathological examination. Internal invoice No. Cost of diagnostic procedure Examination No.: Patient: xxx PESEL: XXX Age: Gender: F Material: Multiple organ resection -- left breast with axillary tissues Unit in charge:. Physician in charge: UUID: D80E9389-AAD8-4EEB-9DE0-50E5785E5F6B TCGA-D8-A139-01A-PR Redacted Material collected on: Aaterial received on: Expected time of examination: up to 8 working days. Clinical diagnosis: Cancer of the left breast. Examination performed on: Results of immunohistochemical examination:. Estrogen receptors found in 10-75% of neoplastic cell nuclei. No progesterone receptors found in neoplastic cell nuclei. HER2 protein stained with HercepTestTM by DAKO. Positive reaction in invasive cancerous cells ( Score = 3+ ) Compliance validated by: Examination performed on Macroscopic description: Left breast sized 18 x 12.5 x 2.5 cm removed along with axillary tissues sized 9 x 5 x 1 cm and a 14 x 4 cm skin flap. Weight 350 g. Tumour sized 1.8 x 1.5 x 1.9 cm on the boundary of outer quadrants, 2.0 cm from the lower boundary, 0.3 cm from the base and 0.7 cm from the skin. Microscopic description: Carcinoma ductale invasivum - NHG2 (2 + 3 +1:4 mitoses/10 HPF, visual area diameter 0.55 mm). Mamilla sine laesionibus. Lesions of the type mastopathia fibrosa et cystic, calcificationes. Invasive lesions situated 7 cm from the base. Axillary lymph nodes: Lymphonodultis chronica et sinus histiocytosis (No. VI).
+
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+page 2 / 2 Histopathological diagnosis: Carcinoma ductale invasivum mammae sinistrae. Invasive ductal carcinoma of the left breast. {NHG2, pT1c, pN0 ). Compliance validated by: CALL YOUR DOCTOR WITH THIS REPORT!
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diff --git a/output/text/7ebd18ee-fddd-4ec4-8553-473aa2d831c0.txt b/output/text/7ebd18ee-fddd-4ec4-8553-473aa2d831c0.txt
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+tcD-6-3 UUID:E3C55935-DC6F-40F9-B529-E0D39775AD9C TCGA-D6-A6EQ-01A-PR Redacted 8071j3 Site  s/24/L3 Department of Cancer Pathology Patient: XXX Age: Gender: M Examination result No. Unit in charge: Surgery and Laryngological Oncology Dept. Physician in charge: Clinical diagnosis (suspicion) Laryngeal carcinoma Date of admission:. Material: 1) Material: larynx. Please mark surgical margins - lower (trachea). Method of collection: Collection of  specimens for laboratory examination Histopathological diagnosis Examination performed on: Invasive keratinising squamous cell carcinoma (G3) of the larynx. Incision lines free of neoplastic lesions. pT3. (8071/3 T-24100)* * codes according to ICD-O-3 or SNOMED Macroscopic description: Surgical specimen sized 9.5 x 7.0 x 3.5cm, including larynx with the hyoid bone and part of the trachea 1.5 cm in length. Tumour found in the glottal region, sized 4.5 x 2.5 x 1.2cm invading the subglottal region, glottis, supraglottal region, aryepiglottic fold on the left side. Assistant: Pathologist: Edited Results of intraoperative examination: Examination performed on: Margins at the side of 1 wire and 2 wires (top) cancerous lesions. Final reply to be given after the analysis of paraffin specimens. Assistant: Pathologist: - Edited CONTACT YOUR DOCTOR WITH THIS REPORT! lw 5J2s/1 rimary Tumor Site Di
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diff --git a/output/text/7ee78fa0-acf8-4c14-9767-33d1593c2500.txt b/output/text/7ee78fa0-acf8-4c14-9767-33d1593c2500.txt
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index 0000000000000000000000000000000000000000..539120caec8d9df6b9a53b8a63a544aa97819ebd
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+UUID:709348FB-E674-4720-B651-901E74E65449 TCGA-4A-A93W-01A-PR Redacted SurgICAl pAthOLOgy rEPOrt Patient: : Accession: DOB:  Age: Sex: F Account: ate Collected: MRN: 1 Date Received: Requested by: Patient Date Reported: Clinical Data: Right renal mass FINAL PAthoLOgIC DiAgNosis 1. Right kidney (14 grams), partial nephrectomy: Papillary renal cell carcinoma. 2. Right kidney (deep margin): Papillary renal cell carcinoma; new margin free of tumor.. D6-3 yDayusesry nenal eekl Synoptic RepOrt Arcintno-j j 8Q6013 Right kidney Tumor site: Histologic type: Papillary renal cell carcinoma 064.9  Sarcomatoid features: Not identified Histologic (Fuhrm an) grade: G2 WO 3|Zc/!4 Tumor size: 3.6 cm Tumor focality: Unifocal Extent of tumor: Tumor is limited to kidney Parenchymal margin:  Negative for malignancy (1.0 cm from tumor) Angiolymphatic invasion: Not identified Surgicai Pathology Staging: pT1a NX Pathologist, Electronic Signature SPECIMEN(S) SUBMITTED: GROSS DESCRIPTION 1. Right renal mass: In formalin labeled "right renal mass" is a 14 gram, 4 x 3.3 x 3.3 cm partial nephrectomy specimen. There is a 3.6 cm lobulated pale tan-red mass present. The mass abuts and elevates the renal capsule; however, no  invasion into or through the capsule is noted. The mass is grossly present, however, at the deep parenchymal resection margin. The perinephric fat is inked black, with the parenchymal margin inked btue. Representative sections submitted in four cassettes, A through D. 2. Deep margin: In formalin labeled "deep margin" is a 3.3 x 1.3 x 1.2 cm portion of renal parenchyma, with an attached  portion of lobulated pale tan-red tumor and an additional 2.5 x 2.5 x 1.3 cm aggregate of loose tumor fragments. The. tumor is grossly 1 cm from what appears to be the true deep margin, which is inked blue. Representative sections submitted in two cassettes, A and B ICD-9 CODE(S): cpt cODe(S): FACILITY: Page 1 of 2
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+SurgiCAl pAthOlOgy rEPOrt - COnTinueD Patient: Result ID: Accessiont 88307, 88305 END OF REPORT
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+UUID: 8C2B719A-D45A-4DF3-BA61-908A2E1F6D1D TCGA-AN-A049-01A-PR Redacted TSS Patient ID: Case #: : DOB: Sex: Female Ethnicity (Race): Cancer Sample Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma Date of Procurement: Anatomic Site: Left Breast Tumor location: Primary Tissue Specification: Tumor Specimen Matrix: Tissue Specimen Format: Frozen Container: cryomold Type of Procurement: Radical mastectomy Grade: 2 T Stage: 2 N Stage: 0 M Stage: 0 Treatment: none Treatment Details: n/a  Normal Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw Matrix: Blood Specimen Format: frozen Container: tube Date of Procurement: 1cs-0-3 oavciionia,nifiltrahny duct, nos 850c/3 Site: breast, nes C50.9 h 10/arJ1
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diff --git a/output/text/7ef39a4f-8d24-4e91-ae98-5ccf6faf4ea0.txt b/output/text/7ef39a4f-8d24-4e91-ae98-5ccf6faf4ea0.txt
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+Surgical Pathology Report Name: Case #: DOB: Collected: Gender: Received: mrn: Reported: Location: Copy To: Physician: Pathologic Interpretation: A. Left axillary lymph node biopsy 1c s-0-3 - One lymph node (1) negative for carcinoma. - Immunohistochemistry for keratin is negative Cancumn, mfiHrufxg 1obular,ns0s 85Rof3 B. Left axlllary lymph node biopsy  : 1c1 Sit: bruot, loww outn qussront c50|5 3/9/n - One lymph node (1) negative for carcinoma. pr - Immunohistochemistry for keratin is negative. CqcF Sitr bust,Nos C50.9 c. Left axillary lymph node biopsy ( One lymph node (1) negative for carcinoma.. - Immunohistochemistry for keratin is negative. D. Left breast mastectomy: INVAsIVE CARCINOMA, with lobular features, moderately differentiated Nottingham grade 2 (3 + 3 + 1= 7). largest extent of tumor grossly measuring 2.0 cm (see note) IN SITU CARCiNOMA, with lobular features, nigh nuclear grade, central comedo necrosis and calcificatipns is present in 4 out of 12 slides (see note). Biopsy site is present. Margins negative for in situ and invasive carcinoma.. UUID:79C0D757-508E-4375-AF69-E577629EE0CA TCGA-EW-A133-01A-PR No lymphovascular invasion is present.. Redacted Immunohistochemical results: Estrogen receptor: Positive Progesterone receptor: Positive HER-2: Positive (3+) E-Cadherin:  Negative  Note: This is an unusual neoplasm with morphologic features of a lobular in situ and invasive carcinoma that is E- cadherin negative, with high nuclear grade and necrosis, and positive HER-2. The biological behavior and dinical course of such neoplasms, which are sometimes referred to as Pleomorphic Lobular Carcinoma, may be similar td ductal carcinomas. Suraical Patholoay Tumor Summary Specimen: Total breast Procedure: Total mastectomy Lymph node sampling: Sentinel lymph node Specimen Integrity: Single intact specimen Specimen Laterality: Left Tumor Slte: Lower outer quadrant Tumor Size: Greatest dimension of largest focus of invasion over 0.1 cm: 2.0 cm Tumor Focallty: Single focus of invasive carcinoma. Skin: Invasive carcinoma does not invade into the dermis or epidermis without skin Skeletal muscle: No skeletal muscle present Lobular carcinoma in situ: Present Histologic Type of Invasive Carcinoma: Invasive carcinoma with lobular features Glandular (Acinar)/Tubular Differentiation: Score 3<10% of the tumor are forming glandular/tubular structures Nuclear Pleomorphism: Score 3: Vesicular nuclei, often with prominent nucleoli, exhibiting marked variation in  In size and shape, occasionally with very large and bizarre forms. Mitotic count: Score 1 Overall grade: Grade 2: scores of 6 or 7 Margins: Margins uninvolved by invasive carcinoma Distance from closest margin: 1.2 cm from deep margin. Lymph-vascular Invaslon: Not identified Lymph nodes: Number of sentinel lymph nodes examined: 3.
+
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+SURGICAL PATHOL Report Total number of lymph nodes examined (sentinel and nonsentinel): 3 Number of lymph nodes with isolated tumor cells (<0.2 mm and <200 cells): 0 Size of largest metastatic deposit (if present): 0 Extranoda! extension: Not identified Method of evaluation of sentinel lymph nodes: Immunohistochemistry (pending) Pathologic staging: pT1c: Tumor >10 mm but <20 mm in greatest dimension. pNO: (i+): Malignant cells in regional lymph nodes no greater than 0.2 cm and no more than 200 cells (detected by|H & E or IHC including (TC). Distant Metastasis: Not applicable Estrogen Receptor: Performed on this specimen Results: Immunoreactive tumor cells present (>1%) Progesterone Receptor: Performed on this specirnen Resuits: Immunoreactive tumor celis present (>1%) HER2/neu: Performed on this specimen Results: Positive (Score 3+) Microcalcifications: Present in situ carcinoma OTE:S yk specific reagen's (AsRs) validoied by ow iasoratory. Thes ASRs are clinically mstful indic dretre FD  Te clowsare othoogit as posis or neg. As the attending pathologist. I attest that I: (i) Examined the relgvant preparation(s) for the specimen(s): and (ii) Rendered the diagnosis(es). ***Electronically Signed Out By*** Procedures/Addenda Addendum Date Ordered: Status: Signed Out Date Complete: 1 Date Reported: Addendum Diagnosis D. LEFT BREAST MASTECTOMY: - The tumor cells are positive for HER2 gene amplification by CISH (performed at. Intraoperative Consultation A. Left axilla 1 . FS: No obvious malignancy; however, immunostains are pending B. Left axilla 1 - FS: No obvious malignancy; however, immunostains are pending. c. Left axilla 1 FS: No obvious malignancy; however, immunostains are pending. Clinical History: Page 2 of .
+
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+SURGICAL PATHOL Report Patient with biopsy-proven infiltrating lobuiar carcinoma. Piease evaluate margins and if sentinel nodes are H&E negative, do immunohistochemistry. Operation Performedd Left total mastectomy with sentinel lymph node biopsy. possible axillary node dissection Pre Qperative Diagnosis: Infiltrating lobular carcinoma of left breast Specimen(s) Rereived: A: Left axilla 1 - FS B: Left axilla 1 - FS C: Left axilla 1 ,-FS D: Left breast Gross Description:d A. Received fresh is a 1 x 1 x 0.2 cm adipose tissue fragment. The specimen is submitted in toto in one block for frozen section. B. Received fresh is a 2 x 1 x 0.6 cm adipose tissue fragment. The specimen is submitted in toto in one block for frozen section. c. Received fresh is a 0.5 x 0.4 x 0.1 cm adipose tissue fragment. The specimen is submitted in toto in one $lock for frozen section. D. Received in formalin is an 871-gram, 20 x 16 x 6 cm mastectomy specimen. An ellipse of skin is identifiect it measures 16 x 9 x 0.2 cm. The nipple and areola measure 1.8 cm and 4.5 cm, respectively. The specimen is oriented with one. stitch superior and two stitches medial. . The specimen is inked and cross sectioned in the frozen room. A2 x 1.5 x 1.2 cm, ill-defined lesion was identified in the left lower outer quadrant. This lesion is located 1.2 cm from the deep resection margin (closest). A 0.2 x 0.1 cm tissue sample was taken by Dr. A 0.3 x 0.3 cm tissue sample was taken for tissue bank. A 0.5 x 0.4 x 0.1 cm tissue sample was taken by Dr. ' , for research. An additional piec of adipose tissue and skin accompanies the specimen; it measures 7.5 x 4 x 2.5 cm. The skin measures 7 x 2.5 x 0.1 cm. Cross sections throughout the specimen show a multilobulated adipose tissue. No lesions are identified. The fat to stroma ratio is 40:60. The specimen is submitted as follows: 1 Section of nipple and areola 2 Lesion in relation to the deep margin (closest) 3-5 Remainder of lesion in toto 6 Section of left upper inner quadrant 7 Section of left lower inner quadrant 8 Section of central compartment 9 Section of left upper outer quadrant 10 Section of left lower outer quadrant 11&12 Sections of additional breast tissue segment Page 3 of :
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+UUID:FFEF1962-F903-4C41-A6D2-8DEF0BD35F55 TCGA-IB-A5SP-01A-PR Redacted Note: If you do not see "End of printed report" at the bottom of the last page of the report You Do not have the entire Report. Please try printing it again. DOB CONFIDENTIAL SURGICAL PATHOLOGy REPORT Time Collected Time Reported Order Number Ordering Provider Status Final  Relevant lerssscirorie-, ductol Information 8ew/3 Location Sete; Aerd pancssco Copied To CQ5 O JtO4/z/13 Report Patient Name: Demographics Date of Birth. (for verification Sex: M purposes) SurgicaL patholOgy report *Surgical Pathology Rep Accession Number Collected Date/Tima Received Date/Time Pathologist Specimen Description A. Mesenteric nodule DV at B. Gallbladder at C. Node of inportance Dv at D. Whippie's specimen devitalized at Clanical Intormation Likely pancreatic cancer. Diaynosls A. Mesenrerte Nodule, Biopsy: Fibrous tissue, negative for maliganncy. 3. Callbladder, Cholecystectory: Chronic cholecyststis. C. Lymph Node (Node of Importanue), Excision: 1 lymph node, negative for malignancy (o/1). D. Pancreas and Duodenun, Whipple Reseetion:
+
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+Page 2 of 4 Invasive moderately-differentiated ductal adenocarcincma (see Synoptic Report!. Pancreatic intraepithel:al neoplasia (Fanin), grade 3/3. Extrapancreatic extension with perineural invasion invclving qrocve and partial resected wall of superior mesenteric vein with positive pancreatic uncinate margin (see Conment). 14 lymph nodes, negative for malignancy (0/l4). Electronically signed by:. Synoptic Report D: Pancreas (Exocrine), Microscopic HESTOLOGIC TYFE: Ductal adenocarcinoma HI STOLOGIC GRADE: 32 :  Moderately differentiated MICROSCOPIC TUMOR EXTENSTON: Tunor invades peripancreatic soft tissues Tunor invades recroperitoneal soft tissue MARGINS: Margin(s) involved by invasive carcinoma Uncinate procese (retroperitoneal) margin surface ot the uncinate process) LYMPH-VASCULAR, INVASION: Not identified PERINEURAL INVASION: Present PRIMARY TUMOR (pT): pT3: Tumor extends beyond the pancreas but without involvement of the celiac axis or the superior mesenteric artery REGIONAL LYMPH NODES (pN): PNO:  No regional lynph node metastasis Number examined: 15 Number involved: ADDITIONAL PATHOLOGIC FINDINGS: Fancreat.c intraepithelial neoplasia (highest grade: PanIn 3 ) D: Pancreas (Exocrine), Macroscopic. SPECIMEN: Head of pancreas Duodenun Jallbladder Adjacent large vessels Superlor mesenteric ven FROCEDURE: Fancreaticoduodenectony (Whspple resection), partial pancreatectomy UMOR SLTE: Pancreatic head TUMOR SIZE: Greatest dimension: cm Grcss Description Received are specimens A to D.  All reauisitions and specimen containers are labelled. with the patient's name The cassettes and Ap identifiers are labelled with the Surgical Number
+
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+Page 3 of 4 A.  One fragment of tan tissue 0.8 x 0.3 x 0.2 cm, submitted entirely for rs.. B. The specinen consists cf a chclecystectony specimen (9.0 x 4.5 x 2.2 cm). The. otherwise unremarkable. Gallbladder wali measures o.5 cm in maximum thicknass and is otherwise unremarkable. The mucosa is roughened, but yrossly unremarkable. The gallbladder contains some mucoid bile, but is otherwise unremarkable. Representative sections are submitted in cassette Bl. C. One lymph node, 1.3 cm in greatest dimension. Bisected and submitted entirely tor r's. D. The specimen consists of a lenguh of stomach (4.5 x 6.0 cm in circunterence), small bowel (23.0 am in length and up to 6.5 cm in diameter), anci attached pancreas and peripancreatic tissue (4.0 x 5.0 x 4.5 cm). Both the bile duct and pancreatic duct are length of what appears to be a partial wall of a bloed yessel within pancreatic groove.. The cormon bile duct is patent to the aupulla.  The pancreatic duct is patent only to 2.5 cm distally before it is occluded. Upon sectioning of the pancreas, there is a poorly. defined fibrous white mass measuring 2.5 x 2.0 x 3.0 cm. It conpletely surrounds the pancreatie duct and abuts the bile duct. Grossly abuts the black painted pancreatic groove and blue painted retroperitoneal margin. The remaining surrounding soft tissue is Jrossly unremarkable.  Representative sections are submitted as follows: D1. pancreatic resection margin D2. bile duct margin. D3.  tumor to black painted pancreatie margin and pancreatic duct D4. tunor to vessel in groove D5-6. tumor to pancreatic margin D7. tumr abuttirg bile duct and bile duct margin D8. tunor surrounding parcreatic tissue D9-10. tumor to blue painted tetroperitoneal margin D11. nomnal pancreas D12. one lymph node bisected D13. two lymph nodes D14. one lymph node bisected D15. three' lynph nodes Dl6. three lymph nodes IC/csh Frozen Section Diagnosis. A.  Mesenteric Nodule: Benign fibrous tissue only. Negative for maligrancy. Cont # C. Node of Inportance: Neyative for malignancy. Conf # Reported by:. Fathologisr Conment Tator with perineural extansion is seen surrounding the partially resected superior. wasenteric vain and involving the soft tissue painted margin surrounding the yein and Wclnate (retroperitoneal ancinate margin positive for malignancy). Accession Number Encounter
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+Page 4 of 4 Number -- End of printed report -
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+Cncmmo, mfiltruting dut 85oo/3 Patient. 7.qcF.brat Nos c5o.9 Surg Path CLINICAL HISTORY: Breast mass. Infiltrating ductal carcinoma. GROSS EXAMINATION: A. "Left breast and axillary contents". Breast in formalin, axillary tail. fresh. Received is a single breast that weighs 610 grams and measures 21.5 x. 14.5 x 4 cm. The specimen consists of an ellipse of skin measuring 18 x 8 cm. The nipple is present. In the upper inner quadrant, there is a hard mass. approximately 2 x 3 x 2 cm. is present in the lower outer quadrant. cross sectioning, the larger mass is firm, tan-white with multiple areas of Upon hemorrhage. The specimen is not gritty. Both the upper outer and lower outer. quadrants contain apparent abundant breast parenchyma. This tissue, although. firm, is not rock hard as the above described mass. Received fresh is an axillary tail weighing 79 grams and measuring 14 x 5 1/2 x 0.8 cm. Five mobile, hard nodules are palpated within the specimen.. Block Summary: Block A1 - A3 - larger mass (upper inner quadrant) at point closest to deep margin. Block A4  - upper outer quadrant, random section Block A5 - lower outer quadrant, random section. Block A6  lower inner quadrant, random section Block A7 - A9 - smaller mass (lower outer quadrant) at point closest to deep margin. Block A10 - nipple Block All - random section of skin. Block A12 - five level III lymph nodes. Block A13 - four level IIr lymph nodes. Block A14 - four level II lymph nodes Block A15 - three level II lymph nodes. Block Al6 - one level II lymph node, bisected. Block A17 - two level I lymph nodes. UUID: 0429FA9A-AD19-424C-94ED-1A902119E559 Block A18 - one level I lymph node, bisected. TCGA-B6-A0RG-01A-PR Redacted DIAGNOSIS: "LEFT BREAST AND AXILLARY CONTENTS": BREAST AND ATTACHED AXILLARY TAG WITH INVASIVE. CARCINOMA, PROBABLY DUCTAL TYPE. (7.0 CM IN GREATEST DIMENSION). HISTOLOGIC GRADE 2, NUCLEAR GRADE 3. REGIONAL LYMPH NODES NEGATIVE PER CANCER, 19 EXAMINED. MARGINS NEGATIVE FOR CANCER.  ALL FINAL SURGICAL Verified by 1 of 1
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+c50.4 CQCF : Srssst,N0j cSO.9 1/25 " Jrgical Pathology Surg Path CLINICAL HISTORY: Right breast mass with needle aspiration compatible with infiltrating ductal carcinoma. Right breast carcinoma.. GROSS EXAMINATION: "Right breast", in formalin. This is a 2700 gram, 36 x 21.5 x 63 cm. A. modified radical mastectomy specimen with an attached skin ellipse 31 x 22 cm. The skin contains circumferential 8.3 x 2.2 cm area and a retracted 1.5 cm nipple. There is no biopsy scar or other skin lesions. Upon sectioning most. of the breast tissue is fibrofatty yellow-white in appearance. In the upper outer quadrant. There is a 3.0 x 2.8 x 3.0 cm firm, infiltrating pink-grey mass. It is 2 cm deep from the skin, 5 cm from the nearest lateral margin and. 5.0 cm from the nearest deep margin. Tissue has been submitted for ER/pR. studies. No other focal lesions are found. Attached is a 13.0 x 9.0 x 4.0. axillary tail containing multiple potential lymph node candidates. A suture demarks level I from levels II and III.. BLOCK SUMMARY: A1-A3- tumor. A4- deep margin.. A5- lateral margin. A6- lower outer quadrant. A7- upper medial quadrant. A8- lower medial quadrant. A9- skin overlying tumor mass. A10- nipple. All- areola. A12- bisected lymph node candidate level I.. UUID: B587CCDD-1ED2-437A-BDF0-684AF474A8A6 A13- three lymph node candidates level I. TCGA-B6-A0WZ-01A-PR Al4- three lymph nod candidates level II.. Redacted A15- five respective lymph node candidates level II. Al6- one bisected lymph node candidate level III.. Al7- one bisected lymph node candidate level III. Al8- three potential lymph node candidates level III.. Dr. . with Dr. DIAGNOSIS: "RIGHT BREAST", (MODIFIED RADICAL MASTECTOMY) : A. INFILTRATING CARCINOMA PRESENT, INFILTRATING DUCTAL (TUBULOLOBULAR.SUBTYPE) N.S.A.B.P HISTOLOGIC GRADE 1-2 OF 3. N.S.A.B.P. NUCLEAR GRADE 1-2 OF 3. GROSS TUMOR SIZE, 3 CM. INVASIVE TUMOR SIZE, 3 CM. LOCATION OF TUMOR, UPPER OUTER QUADRANT. MULTIFOCAL TUMOR, NO. IN SITU CARCINOMA PRESENT OCCUPYING LESS THAN 5% OF TUMOR.S TYPE OF IN SITU CARCINOMA, DUCTAL NON-COMEDO TYPE. STATUS OF NON-NEOPLASTIC BREAST TISSUE, INTRADUCTAL HYPERPLASIA MODERATE,  MICROCYST FORMATION, APOCRINE METAPLASIA, SCLEROSING ADENOSIS. LYMPHATIC/VASCULAR INVASION, PRESENT. SURGICAL MARGIN STATUS, NEGATIVE. Criteri NIPPLE STATUS, PAGET'S DISEASE ABSENT. SKIN STATUS, FREE OF MALIGNANCY. MUSCLE STATUS, NOT SAMPLED.
+
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+LYMPH NODE STATUS, 11 OF 21 LYMPH NODES POSITIVE FOR CARCINOMA (11/21). EXTRACAPSULAR EXTENSION, PRESENT IN 4 OF 21 NODES EXAMINED. SIZE OF LARGEST INVOLVED LYMPH NODE, 1.6 CM. ESTROGEN/PROGESTERONE AND CELL CYCLE ANALYSIS PENDING, YES. Verified by: M.D. Pager# vate Signed: ADDENDUM 1: Tissue was sent to the for assay of the Estrogen and Progesterone receptors. The Estrogen receptor activity was judged as positive with an estimated fmol valve of 127. The Progesterone receptor activity was judged as positive with an estimated fmol valve of 152. Please refer to . for a complete report Verified by: M.D. Pager# Date Signed:
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diff --git a/output/text/7f27a0c5-b919-46a2-957f-dd395de32bf6.txt b/output/text/7f27a0c5-b919-46a2-957f-dd395de32bf6.txt
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+UUID: FDE93561-B0B0-495F-88BD-932EA3B7D02D TCGA-WC-A883-01A-PR Redacted ID03 Accession: Specimen Date/Time: mileal 8770/3 DIAGNOSIS SJt: RChrwiL C693 (A) RIGHT EYE, FNA SAMPLE FOR SEND OUT TESTING ONLY yO1/14/14 (B) RIGhT GLOBE: (1-30%) (61-90%) CHOROIDAL MELANOMA, MIXED EPITHELIOID AND SPINDLED, 18 MM BASE. EXTRAOCULAR EXTENSION PRESENT. TUMOR INVADES SCLERA AND CANAL OF SCHLEMM, EXTENDING TO SUBCONJUNCTIVAL SURFACE Optic nerve negative for tumor. Vortex veins negative for tumor.. (See comment) COMMENT The tumor in the extraocular space near the conjunctiva is entirely covered by conjunctiva/soft tissue ( margins negative). are 1 per 10 high-power fields. The specimen for part A was sent to for further diagnostic testing by . which will be reported separately  the scan documents of. GROSS DESCRIPTION (A) RIGHT EYE, FOR SEND OUT TESTING-pale-gray semitransparent tissue (0.4 x 0.4 x 0.2 cm) within pink-red fluid (0.E x 0.5 cm) in a sealed container. The specimen is forwarded for send out testing.. (B) RIGHT GLOBE - An enucleation specimen consisting of an intact left lobe (21.0 x 20.0 x 21.0 mm) with an attached 13. optic nerve. The cornea is 11.0 x 10.0 mm with a round central 2.0 mm pupil. The iris is pale gray-yellow with possible rim c hyperpigmentation over approximately one-third peripherally. 1.0 mm from the limbus and adjacent to the area of possible pigmentation, a black 2.0 mm probable tumor nodule is present on the external surface of the sclera with loosely adherent conjunctiva covering the entire surface coming to less than 1.0 mm from the resection edge.. An irregular Intraocular multinodular mass with a base approximately 18.0 mm in greatest dirnension extends from t and comes to 5.0 mm from the optic nerve within the choroidal space. The mass is located between 2.0 and 6 o'clock. Tum harvested fresh per protocol. The tumor has a maximum height post harvest 4.0 mm and the tumor surface is binodular. A suggested from the external surface, the region of extraocular extension noted on the sclera covered by cornea is visible ad. to the tumor. The tumor flattens and becomes thickened again in kind of a rolling/ binodular pattern. An artificial lens is in p SECT!ON CODE: B1, regions of vortex veins; B2, optic-nerve margin; B3, B4, calottes with tumor (B3 with exlraoci extension and in extraocular tissue harvest); B5, pupil-optic section with tumor. BIOMARKER TESTING Primary tumor B5 CLINICAL HISTORY Right eye uveal melanoma SNOMED CODES T-AA000, M-87203 "Some tests reported here may have been developed and pe These tests have no
+
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+Page: 2 Accession: Specimen Date/Time: specific ally cleared or approved by the U S.Food and Drug Adrninistration Entire report and diagnosis completed by: END OF REPORT-
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+TCGA-CJ-4888 DIAGNOSIS (A) Left kidney: RENAl CELl CARcINOmA, COnVenTIONal (CLEaR), CELl TYPE, fUHrmaN'S nUCLEAR GRADE 4 (5.8 CM). TUmOR inVadINg FOCaLLy RENAl SinUS FAT. REnAl CELl CARCINOmA, PaPILLARy TYPE, fUHRMAn'S NUCLEAR GRaDE 2 (1.0 Cm, UPPER POLE). Vascular and urethral margin of resection free of tumor. Renal cortical adenoma.. COMMENT The kidney contains two separate tumors. The largest tumor (5.8 cm) is Iocated in the middle of the kidney. Thls tumor invades focally the adipose tissue of the renal sinus. The second tumor focus (1.1 cm) is located in the upper pole. This tumor is histologically different from the main tumor and has the histologic features of a papillary renal cell carcinoma. Additional deeper sections from muitiple blocks were examined. GROSS DESCRIPTION (A) LEFT KIDNEY - A radical nephrectomy product (17.0 x 16.0 x 6.0 cm overall) with the attached ureter (10.0 x 0.3 x 0.3 cm). An ill-defined tumor (5.8 x 5.0 x 5.0 cm) with a variegated yellow-tan appearance with focal hemorrhage and collagenous changes is present in the middle pole of the kidney, 0.5 cm from the closest pelvis. The tumor focally infiltrates into the perirenal adipose tissue. The tumor spreads through the renal parenchyma into adjacent cortex and forms multiple separate nodules (0.3 to 1.5 cm in greatest dimension). The main tumor focally goes into the sinus. A second tumor (1.1 x 1.1 x 1.0 cm) is present in the upper pole (3.5 cm superior to the first tumor) which has a yellow and homogeneous consistency. It is located in the cortex, 1.3 cm away from the closest sinus/calyces. The remaining rena! parenchyma and renal pelvis is grossly unremarkable. The tumor is not present in the renal vein. INK coDE: The surface of the specimen near the tumor is inked in black. SECTION CODE: A1, ureter margin, renal artery margin, renal vein margin, en face; A2-A5, the larger tumor with possible sinus involvement; A6-A11, the larger tumor with adjacent nodules; A12-A18, tumor with adjacent perirenal fat and cortex; A19-20, the larger tumor with the closest hilum; A21, A22, A24, the smaller tumor with cortex, entirely submitted; A25, unremarkable renal parenchyma.  Representative sections of two tumors are submitted for EM on hold and tumor bank. CLINICAL HISTORy Left renal mass. SNOMED CODES T-71000, M-83123, M-Y7343
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+
+--- Page 1 ---
+-01A-PR Reda ted Surgica! Pathology Report FINAL DIAGNOSIS A) Ureter, left, distal margin, biopsy: tcD-o-3 - Negative for malignancy Counomes-ywrstheQeoQ NOS 8/20/3 B) Ureter, right, distal margin, biopsy: - Negative for malignancy. Site olatialwallg blsdoler Ce7.2 C) Urethra, margin, biopsy: - Negative for malignancy jJs|i7/h3 Per t3s, sgumow difuntrtm is n 4o3. D) Bladder, cystectomy: - High-grade urothelial carcinoma with focal squamous differentiation (WHO grade 3/3), 2.9 cm greatest dimension, invasive through the muscularis propria and into perivesical adipose tissue, with perineural invasion (see microscopic description) - Focal high-grade urothelial carcinoma in-situ of bladder dome. - Extensive follicular cystitis. - Granulation tissue and chronic inflammation with urothelial regeneration, consistent with previous. biopsy site E) Lymph node, left obturator, dissection:. - One lymph node negative for malignancy (0/1). F) Lymph node, left external iliac, dissection: - One lymph node negative for malignancy (0/1) G) Lymph node, right external iliac, dissection:. - One lymph node negative for malignancy (0/1) H) Lymph node, right obturator, dissection:. - Nine lymph nodes negative for malignancy (0/9) I) Lymph node, right common iliac, dissection: - Three lymph nodes negative for malignancy (0/3) J) Lymph node, left common iliac, dissection: - Four lymph nodes negative for malignancy (0/4) K) Lymph node, right internal iliac, dissection: - One lymph node negative for malignancy (0/1). 1
+
+--- Page 2 ---
+Surgical Pathology Report CLInICAL hIsTORy -year-old with hematuria with left bladder wall tumor.. MICROSCOPIC DESCRIPTION Specimen: Bladders Procedure: Radical cystectomy Tumor Site: Left lateral wall Tumor Sizee Greatest dimension: 2.9 cm Additional dimensions: 2.5 x 1.5 cm Histologic Type: Urothelial (transitional cell) carcinoma with focal squamous differentiation Associated Epithelial Lesions: Urothelial carcinoma in-situ. Histologic Grade: High-grade Tumor Configuratlon: Solid, Infiltrating Mlcroscopic Tumor Extension: Perivesical fat. Margins: Margins uninvolved by invasive carcinoma. Distance of invasive carcinoma from closest margin: 5 mm Specify margin: Radial Perineural invasion: present Lymph-Vascular Invasion: Indeterminate. Staging:e Primary Tumor (pT): pT3a: Tumor invades perivesical tissue microscopically. Regional Lymph Nodes (pN): pN0: No lymph node metastasis. Number of Lymph Nodes Examined: 20 Number of Lymph Nodes Involved: 0 Distant Metastasis (pM): pMX (Not applicable) Additional Pathologic Findings: Inflammation/regenerative changes. GrOSS DESCRIPTION Received are 11 specimens, labeled. submitted in its entirety in cassette (FSA1) for intraoperative diagnosis..
+
+--- Page 3 ---
+Surgical Pathology Report B) Received fresh and designated "right distal ureter," is a 1x 0.4 x 0.2 cm red, soft tissue with ureter lumen, submitted in its entirety in cassette (FsB1) for intraoperative diagnosis. C) Received fresh designated "urethral margin," inked distal -- non-inked proximal," is a 1.8 x 1 x 0.3 cm soft tissue with urethral lumen. Submitted in its entirety in cassette (FsC1) for intraoperative diagnosis. D) Received in formalin designated "bladder," is a bladder with 12 x 8 x 1 cm of perivesicular fat. The bladder dome to urethra is 5.5 cm right to ieft is 10 cm and anterior to posterior is 5 cm. A 2 x 1.4 cm tan ulcerative lesion.  with evidence of prior biopsy is identified in the anterior lateral left bladder wall, 2.4 cm from the urethral margin and 3 cm from the left ureter orifice. The posterior surgical margin adjacent to the mass is inked black. On the cut. surface the mass is firm and tan and extends 1.5 cm from the bladder mucosa into the wall and detrusor muscles. The mass is 0.1 cm from the posterior soft tissue margin. After sectioning, the mass measures 2.5 x 1.5 x 2.9 cm. Representative sections are submitted as follows: (D1) Tumor to soft tissue margin (D2-D3) Sections of tumor (D4) Tumor to closest adjacent mucosa (D5) Right ureteral orifice (D6) Left ureteral orifice (D7) Bladder neck. (D8) Dome (D9) Right wall (D10) Left wall (D11) Posterior wall. (D12) Anterior wall. (D13) Trigone (D14-D22) perivesicular fat E) In formalin, labeled "ieft obturator node," are 3 cm of lobular fatty tissue with an interspersed lymph node which. is fusiform, 1 cm in greatest dimension. The lymph node is submitted in its entirety as (E1). F) In formalin, labeled "L external iliac lymph node," is a lobular fatty tissue, 5.5 x 3.5 x 1.5 cm, with a central lymph node, 3.9 x 2.5 x 0.9 cm. The lymph node is submitted in its entirety as (F1-F5). G) In formalin, labeled "R external iiac LN," is a 4 x 2.9 x 1.1 cm lymph node with abundant attached fat. The lymph node is submitted in its entirety as (G1-G5). H) In formalin, labeled "right obturator iymph node," are 4 x 3 x 1.5 cm with lobular fatty tissues with interspersed Jymph nodes. The lymph nodes range from 0.6 cm to 1.5 cm. The lymph nodes are submitted in their entirety as follows: 3
+
+--- Page 4 ---
+Surgical Pathology Report (H1) Two lymph node candidates (H2) Two lymph node candidates (H3) One bisected lymph node (H4) Multiple lymph node candidates I) In formalin, labeled "R common iliac lymph node," are fatty tissues, 2.5 cm in aggregate, with interspersed lymph nodes up to 1.5 cm. The lymph nodes are submitted in toto, one block as (l1). J) In formalin, labeled "L common iliac lymph nodes," are multiple lymph nodes up to 1.1 cm with abundant attached fat. The lymph nodes are submitted as (J1-J2) in toto. K) In formalin, labeled "R internal iliac LN," is a 2.9 x 2.5 x 0.9 cm encapsulated nodule suggestive of a lymph node with moderate attached fat. The cut surface is pink and homogeneous. In its entirety as (K1-K3).
+
+--- Page 5 ---
+Page 1 of 1 TCGA Pathologic Diagnosis Discrepancy Form 4.05 ) Study Subject Person ID: N/A ID: Study/Site: TCGA Bladder Urothelial Carcinoma - N/A (Bladder Urothelial Age: Carcinoma) Event: PathDiscrepancy Date of Birth: Interviewer: Tumor Identifier Provided on Initial Case Provide the tumor identifier documented on the initial case quality. Quality Control Form control form for this case.  Pathologic Diagnosis Provided Focal squamous Provide the diagnosis/ histologic subtype(s) documented on the initial on Initial Pathology Report differentiation pathology report for this case. If the histology for this case is mixed, provide. all listed subtypes.  Histologic features of the sample provided for 40% Provide the histologic features selected on the TCGA Case. TCGA, as reflected on the CQCF squamous Quality Control Form completed for this case. Discrepancy between Pathology Report and Case Quality Control Form Provide the reason for the Section submitted to TCGA had more  Provide a reason describing why the diagnosis on discrepancy between the pathology  squamous differentiation than the  the initial pathology report for this case is not report and the TCGA Case Quality  whole tumor submitted for permanent. consistent with the diagnosis selected on the TCGA Control Form Case Quality Control Form. Name of Tss Reviewing Pathologist or Biorepository. Provide the name of the pathologist who reviewed this case. Director for TCGA.
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diff --git a/output/text/7f7b1b24-a317-489b-84dd-77d44f45502a.txt b/output/text/7f7b1b24-a317-489b-84dd-77d44f45502a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1a74e576507d0cb65d8c854c71f8c13c3c374726
--- /dev/null
+++ b/output/text/7f7b1b24-a317-489b-84dd-77d44f45502a.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1c0-0 -3 UUID:7594A7F8-1806-4874-99EF-4E4C889E7BEA TCGA-AR-A0TV-01A-PR 'Redacted Catnoma, mif(fnatng cluctl, nos 85oef3 Sin: 5riaot, Nv s C5o.9 Breast, left, simple mastectomy: Infiltrating Nottingham grade III (of III) ductal carcinoma forming a 2.6. x 2.4 x 2.0 cm (AJCC pT2) mass located in the outer quadrant. No angiolymphatic invasion identified. No significant ductal carcinoma in situ component identified. A separate hyalinized fibroadenoma (1.2 x. 1.0 x 1.0 cm) is present superior to the tumor mass. The nipple and skin are unremarkable. Lymph nodes, left axillary sentinel, excision: Multiple (3) left axillary sentinel lymph nodes are negative for tumor. Blue dye is identified in left axillary sentinel lymph node No. 1. Blue dye is not identified in. left axillary sentinel lymph nodes No. 2 and No. 3. Immunohistochemical cytokeratin stain was performed on the paraffin embedded sentinel lymph node tissue and confirms the H&E impression. [AJCCpN0(i-)] Her-2/NEU has been ordered on paraffin embedded tissue.
\ No newline at end of file
diff --git a/output/text/7fa445f5-59fe-43a2-a73e-95880b0acb4c.txt b/output/text/7fa445f5-59fe-43a2-a73e-95880b0acb4c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1b7e1f0020206bfecbeb2315515b59d14da2a790
--- /dev/null
+++ b/output/text/7fa445f5-59fe-43a2-a73e-95880b0acb4c.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Formatted Path Report LARGE INTESTINE TISSUE CHECKLIST Specimen type: Partial colectomy Specimen size: Not specified Tumor site: Ascending colon Tumor size: 0 x 0 x 8.5 cm Tumor features: Ulcerated Histologic type: Adenocarcinoma Histologic grade: Moderately differentiated Tumor extent: Subserosa Lymph nodes: 0/12 positive for metastasis (Adjacent fatty tissue 0/12) Margins: Uninvolved Evidence of neo-adjuvant treatment: Not specified. Additional pathologic findings: Not specified Comments: None
+
+--- Page 2 ---
+Date of Procurement
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diff --git a/output/text/801a0d3b-d618-4b3c-906c-64fb1cef2711.txt b/output/text/801a0d3b-d618-4b3c-906c-64fb1cef2711.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fb2a4bd821616772da75926643290bba89e32d4c
--- /dev/null
+++ b/output/text/801a0d3b-d618-4b3c-906c-64fb1cef2711.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+PATIENT HISTORY: The patient is a PRE-OP DIAGNOSIS. Colon cancer POST-OP DIAGNOSIS Same. FROCEDURE: Sigmoid colectomy. ADDENDA: Addendum Fluorescence in situ hybridization studies demonstrate that the adenocarcinoma has a ratio of Her-2/Neu gene to the. centromere chromosome 17 of 1.19 indicating a lack of amplification in the targeted region..  Her2/neu amplification may help in identifying those patients likely to experience shorter survival when considered together with other najor risk factors. FINAL DIAGNOSIS: COLon, sigmoid, segmental colectomy - INVAsivVe moDerAteLy DiffErenTiAteD ADenOcARcinomA (3.7 Cm) iNvaDinG into eUt not throUGH MUScULariS ProPRia WITh intramUral aBsCESS. 3.  SUrgical. margins negative for malignancy. Three (3) Lymph nODes nEgative FOr mALiGnancy (see comment).e D NO ANGIOLYMPHATIC OR PERINEURAL INVASION IDENTIFIED. E. PATHOLOGIC STAGE: pT2 NO MX, DUKES A. ACKGROUND COLON WITH CRYPT BRANCHING. COMMENT: Pericolonic adipose tissue was extensively sectioned and additional sections of pericalanlc adipose tissue were submitted but no additional lymph nodes were identified SYNOPTIC - PRIMARY COLON AND RECTAL TUMORS Location:5 Heocecal Region 4 Descending Colon Ascending Colon  Sigmoid Colon  Transverse Coion Rectum Procedure: 1 Segmental Colectomy 3.  Other 2. Total Colectomy Size of Tumor (maximum dimension): 3.7 cm Type: 1  Adenocarcinoma, NOS 9. Squamous Cell Carcinoma  Adnocarcinoma arising in a background 10. Undifferentiated Carcinoma of an adenoma. 11. Sarcona  Adenocarcinoma arising in a background 12. Smooth Muscle Tumor 3. of inflammatory bowel disease 13. Gastrointestinal stromal tumor 4 Adenosquamous carcinoma 14. Lyrnphoma Carcinoid Tumor (Neuroendocrine Turnor) 15.Other 6, Mucinous Adenocarcinoma Signet ring cell type Adenocarcinoma 8. Neuroendocrine Carcinoma Grade: 2 1. Well differentiated 2.Moderately differentiated 3. Poorly differentiated Extent of Infiltration: 3 Limited to the mucosa 4. Infiltrating through muscularis propria into serosa!. 2. Into subrnucosa adipose tissue Involving muscularis propria 5. Involving adjacent organs/ pelvic wall Angiolymphatic Invasion.  2 1.Yes 2. No Surgical Margins Involved: 2 Yes 2. No  Number ot positive lymph nodes: 0 Total number of lymph nodes examined: K Extracapsular spread : 2 Yes No. Associated conditions. None Uicerative colitis. Crohn's Disease. 3. History/ presence of adenomatous polyps. 4. Multiple palyposis syndromes. 3. Diverticulosis. M. TNM Stage: T2 N mX N. Dukes Stage:1 A (limited to mucosa and muscularis) B (through muscularis into subserosa) 3. C (affecting lymph nodes) D (metastatic) O. Astler-Colier Stage: 2 A (mucosa but not into muscularis propria) B1 (muscularis propria but not through to subserosa)  02 (through muscularis propria into subserosal fibroadipose tissue, LN negative). C1 (iimited to muscularis propria but not through subserosa, Ln postive) C2 (invades serosal adipose tissue. LN positive) 6. D (metastatic disease)
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diff --git a/output/text/801c2317-dbaa-42b7-a843-124530f31684.txt b/output/text/801c2317-dbaa-42b7-a843-124530f31684.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2aa7facffc86bfef36350ebced5e98f076a0fb71
--- /dev/null
+++ b/output/text/801c2317-dbaa-42b7-a843-124530f31684.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Patient history: The patient is a three or more mets involving liver. Bilateral renal masses which are solid and cystic. Previous cerebral vascular accident with history of hypertension.. PRE OP DiAGNO$IS: Colon cancer. Post op Diagnosis: Same.  PROCEDURE: Liver biopsy, right hemicolectomy, open cholecystectomy, intraoperative ultrasound, right nephrectomy. ADDENDA: Addendum Fiuorescent in situ hybridization studies have been performed on the poorly differentiated colonic adenocarcinoma. The ratio of HER-2/neu to the centromere of chromosome 17 is 1.70, indicating low level HER-2/neu amplification in the targeted region. Her2/neu amplification may help in identifying those patients Jikely to experience shorter survival when considered. tdgether with other major risk factors.. FINAL DIAGNOSIS: Part 1: Liver, biopsy - METaSTaTIC mUcinoUS ADenOCArciNomA, CONSIStenT wITh PATIenT'S COLOn PrImAry (see comment). Part 2: Gallbladder, cholecystectomy - GALLBLADDER WITH CHRONIC CHOLECYSTITIS PART 3: KIDNEY, RIGHT,EXCISION OF MASS- A. muLTIpLe ReNaL COrTICaL CyStS WITh ASSOCIaTEd hemoRRhAge AnD ORganIzINg hemaToMA. B. NO EVIDENCE OF MALIGNANCY. PART 4: COLON, RIGHT HEMICOLECTOMY -  INVASIVE POORLY DIFFERENTIATED ADENOCARCINOMA WITH AREAS OF MUCINOUS DIFFERENTIATION see comment), B. THE CARCINOMA SHOWS INVASION THROUGH MUSCULARIS PROPRIA AND INTO SEROSAL ADIPOSE TISSUE. C. METaSTATIC ADENOCaRCINOMA IS PRESENT WITHIN ONE OF TEN LyMPH NODES, 4.O CM, WITH FOCAL EXTRACAPSULAR EXTENSION. ALL EXAMINED RESECTION MARGiNS ARE FREE OF TUMOR. E. Stage: t4 n1 m1, Duke c, Astler collier c2. APPENDIX WITh nO SIGNIFICanT PATHOLOGIC CHANGE. COMMEN Much of this tumor is a well differentiated adenocarcinoma, and the pericolonic lymph node metastasis from part 4 is of this pattern. However, some of the deeply invasive tumor is mucinous, and this pattern is present in the liver biopsy. Trichrome and PAS stains were performed on the liver biopsy ( part 1). The trichrome stain highlights desmoplastic fibrosis within the metastatic carcinoma. The PAS stain highlights intracellular and extracellular mucin within the metastatic carcinoma.
+
+--- Page 2 ---
+SynopTic - primary Colon And rectal tumOrs A. Location: 2 1. Ileocecal Region 4.  Descending Colon 2. Ascending Colon 5.  Sigmoid Colon 3. Transverse Colon 6. Rectum B. Procedure: 1 Segmental Colectomy 3. Other Total Colectomy C. Size of Tumor (maximum dimension): 6.5 cm D. Type: 1 1 Adenocarcinona, NOS 9. Squamous Cell Carcinoma 2.  Adenocarcinoma arising in a background 10. Undifferentiated Carcinoma of an adenoma. 11. Sarcoma 3. Adenocarcinoma arising in a background 12.  Smooth Muscle Tumor of inflammatory bowel disease 13. Gastrointestinal stromal tumor 4. Adenosquamous carcinoma 14. Lymphoma Carcinoid Tumor (Neuroendocrine Turmor) 15. Other 5. 6.  Mucinous Adenocarcinoma 7. Signet ring cell type Adenocarcinoma 8.  Neuroendocrine Carcinoma E. Grade: 3 1. Well differentiated 2. Moderately differentiated 3. Poory differentiated F Extent of Infiltration: 4 1. Limited to the mucosa 4. Infiltrating through muscularis propria into serosal  Into submucosa adipose tissue 3.  Involving muscularis propria 5. Involving adjacent organs/ pelvic wall G. Angiolymphatic Invasion:- Yes 2. No 1 Surgical Margins Involved: 2 1 Yes 2. No I. Regional Lymph Node Involvement: 1 1."Yes 2. No J. If regional lymph nodes involved, Number positive/number examined: 1/10. K. Extracapsular spread : 1 1. Yes No. L. Associated conditions: #/#/#/# 1. Ulcerative colitis. 2. Crohn's Disease. 3. Historyl presence of adenomatous polyps. 4.  Multiple polyposis syndromes. Diverticulosis. M. TNM Stage: T4 N1 M 1 N. Dukes' Stage: 3 A (limited to mucosa and muscularis) 2. B (through rmuscularis into subserosa)  C (through subserosa and invoiving adjacent organ/pelvic wall/regional or distant lymph nodes) 0. Astler - Coller Stage: C2  A (mucosa but not into muscularis propria) 1. 2. B1 (rnuscularis propria but not through, LN negative) 3.  B2 (through muscularis propria into subserosal fibroadipose tissue, LN negative) 4. C1 (limited to muscularis propria but not through serosa, LN positive) 5. C2 (invades serosal adipose tissue, LN positive)
\ No newline at end of file
diff --git a/output/text/801c5803-c94a-482c-9356-37f4dc139354.txt b/output/text/801c5803-c94a-482c-9356-37f4dc139354.txt
new file mode 100644
index 0000000000000000000000000000000000000000..bb8e2e008fddd80bb49cd051eef25a650e8ca6ab
--- /dev/null
+++ b/output/text/801c5803-c94a-482c-9356-37f4dc139354.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+Specimen(s) Received 1. Neck: Contents right neck, left neck, mandibulectomy, intra oral resection right floor of mouth 2. Neck: Left level 2 neck dissection 3. Oral Cavity: Soft palate margin/QS 4. Orat Cavity: Deep margin/QS 5. Oral Cavity: Tongue margin/QS 6. Surgical Waste Diagnosis 1. Oral cavity; contents right neck, left neck, mandibulectomy, and intra-oral resection right floor of mouth.. Squamous cell carcinoma, poorly differentiated. a. The tumor involves mandible, floor of mouth, right sublingual gland, and soft tissues of level I. b. Tumor maximum diameter 7.0 cm. c. Perineural invasion is present. d. No lymphatic/vascular invasion. e. Margins of resection negative for tumor. The tumor is close to lateral and medial (0.1 and 0.2 cm) soft tissue margins of the neck, and soft tissue margins of floor of mouth (0.3 cm). f. Decalcified sections of the mandible are pending. An addendum report will follow. g. Metastatic squamous cell carcinoma involving eighteen of thirty-four right neck lymph nodes (18/34).. i. The largest lymph node invoived measures 5.0 cm. ii. Extensive extranodal invasion is present. il.  The lymph nodes involved are in levels II-V. h. Metastatic squamous cell carcinoma involving one of twenty-one left neck lymph nodes (1/21).. i. The largest lymph node involved measures 1.7 cm. jj. No extranodal invasion is present. ill. The lymph node involved is in level IV. 2. Left level II neck dissection. One lymph node negative for tumor (0/1). 3. Soft palate margin. Squamous mucosa negative for tumor. 4. Deep margin. Minor salivary glands and soft tissues negative for tumor. 5. Tongue margin. Squamous mucosa negative for tumor. Page 1 of 4
+
+--- Page 2 ---
+Surgical Pathology Consultation Report 6. Surgical waste.. Fragments of skin, bone, and soft tissues with no pathologic changes. (Gross examination only) Synoptic Data Specimen Type: Resection:contents right neck, left neck, mandibulectomy, and intra-oral resection right. floor of mouth.. Tumor Site: Oral Cavity Histologic Type: Squamous cell carcinoma, conventional. Tumor Size: Greatest dimension: 7.0 cm Histologic Grade:. G3: Poorly differentiated Venous/Lymphatic (Large/Small Vessel) Invasion (V/L): Absent Perineural Invasion:. Present Margins: Margins uninvolved by tumor Margins uninvolved by tumor - Distance of tumor from closest margin: 0.1 cm Margins: The tumor is close to lateral and medial (0.1 and 0.2 cm) soft tissue margins of the neck, and soft tissue margins of floor of mouth (0.3 cm). Pathologic Staging (pTNM): pT4a: Oral cavity: Tumor invades adjacent structures (eg, through cortical bone,. into deep [extrinsic] muscle of tongue [genioglossus, hyoglossus, palatoglossus, and. styloglossus], maxillary sinus, skin of face). pN2c: Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in. greatest dimension for all aerodigestive sites except nasopharynx. : Number of regional lymph nodes examined: 56. ' Number of regional lymph nodes involved: 19 Extra-capsular extension of nodal tumor: Present. pMX: Distant metastasis cannot be assessed Clinical History oral ca Gross Description. 1. The specimen is labeled with the patient's name and NCK: Contents right neck, left neck, mandibulectomy, intraoral resection right floor of mouth". It consists of a segment of mandible, with attached floor of mouth and bilateral neck dissections with overall measurements of 11.0 cm AP x 22.5 Sl x 10.0 ML cm. The portion of right mandible measures 6.0 cm AP x 2.5 cm SI x 3.0 cm ML. The lower alveolar ridge is edentulous. There is a tumor arising in the alveolar ridge. The tumor measures 5.5 AP x 7.0 SI x 4.7 ML cm. The tumor appears ulcerated and involves mandibular bone, floor of mouth and the adjacent right neck dissection, where it forms a large, partially necrotic mass, substantially replacing the right level I with extension into level Il. The tumor involves the right parotid and right submandibular glands. The tumor is Iocated at 0.1 cm from the closest right lateral soft tissue margin. The distance from the remaining margins to the tumor are as follows: anterior alveolar mucosa 1.0 cm, posterior alveolar mucosa 1.8 cm, right lateral alveolar mucosa 0.4 cm, anterior floor of mouth mucosa 0.8 cm, posterior floor of mouth mucosa 0.5 cm, medial floor of mouth mucosa 0.6 cm, right anterior soft tissue 1.3 cm, right posterior soft tissue 0.8 cm, medial soft tissue 0.2 cm and inferior to floor of mouth soft tissue 0.3 cm. The right neck dissection measures 9.0 cm AP by 15.3 cm Sl by 5.5 cm ML. and includes levels I, If, I, IV and V. The right submandibular gland measures 4.2 x 2.5 x 2.0 cm and is grossly involved by tumor. The right sternocleidomastoid muscle measures 10.3 x 4.0 x 2.8 cm and is adjacent to, but not grossly involved by tumor. The left neck dissection measures 5.5 cm AP by 17.3 cm SI by 2.5 cm ML and includes levels I, II, IlI and lV. The left submandibular gland measures 3.8 x 2.7 x 1.8 cm and is grossly unremarkable. The left sternocleidomastoid muscle is absent. Multiple lymph nodes are present in all levels, measuring from 0.2 to 5.0 cm in maximum dimension. Several Page 2 of 4
+
+--- Page 3 ---
+Surgical Pathology Consultation Report large nodes within right levels IIl and Ill are obviously involved by tumor. Multiple pieces of tumor and normal tissue are taken for the tissue bank. Representative sections are submitted. 1A right anterior alveolar ridge mucosal margin, margin marked with India ink 1B right posterior alveolar ridge mucosal margin with tumor 1C right lateral alveolar ridge mucosal margin with tumor 1D right anterior floor of mouth mucosal margin with tumor 1E right posterior floor of mouth mucosal margin with tumor 1F right medial floor of mouth mmucosal margin with tumor 1G right anterior soft tissue margin with tumor 1H right posterior soft tissue margin with tumor 11 medial soft tissue margin with tumor 1J right lateral soft tissue margin with tumor 1K inferior to floor of mouth soft tissue margin with tumor 1L right parotid gland involved by tumor 1M right submandibular gland involved by tumor 1N-1O right sternocleidomastoid muscle with adjacent tumor 1P-1Q right level Il lymph nodes grossly involved by tumor, one representative section per node per block 1R right level lI, three lymph nodes 1S-1T right level III lymph nodes grossly involved by tumor, one representative section per node per block. 1U-1V right level III, one lymph node per block. 1W right level III, two lymph nodes 1X right level III, three lymph nodes 1Y right level IV, one lymph node 1Z-1AA right level IV, three lymph nodes per block 1AB right level V, one lymph node 1AC-1AD right level V, one lymph node per block 1AE-1AG right level V, two lymph nodes per block. 1AH right level V, three lymph nodes 1AI left submandibular gland. 1AJ left level I, one lymph node 1AK left level I, one lymph node 1AL-1AN left level II, two lymph nodes per block 1AO-1AP left level ill, one lymph node per block 1AQ left leve III, three lymph nodes 1AR left level III, four lymph nodes 1AS left level IV, one lymph node 1AT-1AV left level IV, two lymph nodes per block. 1AW-1AX anterior mandible margin en face, bisected superior-inferior, decalcified 1AY-1AZ posterior mandible margin en face, bisected superior-inferior, decalcified 1BA-1BB each block containing a full thickness section of mandible, with mass, decalcified 2. The specimen is labeled with the patient's name and "neck: Left level 2 neck dissection". It consists of two irregular pieces of soft tissue measuring 0.6 x 0.2 x 0.2 and 0.8 x 0.6 x 0.3 cm. 2A  specimen in toto. 3. The specimen is labeled with the patient's name and "Oral cavity: Soft palate margin/QS". It consists of a fragment of tissue measuring 1.2 x 0.2 x 0.2 cm. The specimen is submitted in toto for frozen section. 2A frozen section control 4. The specimen is labeled with the patient's name and "Oral cavity: Deep margin/Qs". It consists of a fragment of tissue measuring 0.4 x 0.4 x 0.4 cm. The specimen is submitted in toto for frozen section. 4A  frozen section controln. 5. The specimen is labeled with the patient's name and "Oral cavity: Tongue margin/Qs". It consists of a fragment of. tissue measuring 1.4 x 0.3 x 0.2 cm. The specimen is submitted in toto for frozen section.. 5A frozen section control 6. The specimen is labeled with the patient's name and "surgical waste". It consists of an 8.2 x 8.0 x 2.8 cm aggregate of unremarkable bone, skin and soft tissue pieces. No sections for microscopic are submitted. Page 3 ot 4.
+
+--- Page 4 ---
+Surgical Pathology Consultation Report Quick Section Diagnosis. 3-5: Margins (soft palate, deep, tongue): Negative for malignancy.. Addendum Addendum Comment Decalcified sections shows extensive invasion of the mandible by squamous cell carcinoma. The bone margins of resection are negative for carcinoma.. Page 4 of 4
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diff --git a/output/text/8058d317-d430-4555-be4e-799c889b533b.txt b/output/text/8058d317-d430-4555-be4e-799c889b533b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..691aabffd0e982dda370855fd5e4c6fad1dd621c
--- /dev/null
+++ b/output/text/8058d317-d430-4555-be4e-799c889b533b.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+1cD-0 -3 Carcinoma, nifytrat'ng duct, N0s 8500|3 12/8/10 lw Site Wod: breost, NOs c 50.9 TSS F1-7378-4FD2-8A1D-F935488DE510 Redacted SPECIMENS: TCGA-E2 A. WLE RIGHT BREAST NEEDLE LOCALIZATION B. SENTINEL L.N. #1 RIGHT AXILLA C. SENTINEL L.N. #2 D. SENTINEL L.N. #3 E. SENTINEL L.N. #4 SPECIMEN(S): A. WLE RIGHT BREAST NEEDLE LOCALiZATIONE B. SENTINEL L.N. #1 RIGHT AXILLA C. SENTINEL L.N. #2 D. SENTINEL L.N. #3 E. SENTINEL L.N. #4 GROSS DESCRIPTION: A. WLE RIGHT BREAST NEEDLE LOCALIZATION Received fresh labeled with the patient's identification and 'WLE right breast needle localization'" is a previously inked 70g, 8 x 5 x 4cm needle localized lumpectomy with radiograph. Ink code: anterior-yellow, posterior-black,  superior-biue, inferior-orange, medial-green, ateral-red. Specimen is serially sectioned from lateral to medial into 9  slices revealing a tan white firm stellate 1.9 x 1.6 x 1.5cm mass, 0.7cm from the closest posterior margin in slices 3- 6. Representatively submitted: A1-A2: lateral margin slice 1 A3: next to mass slice 2 A4-A8: slice 3 with mass - deep margin A4 A9: mass with deep margin slice 4 A10: inferior margin slice 4 A11-A12: slice 5 A13: mass with deep margin slice 6 A14: slice 7 A15: slice 8 A16: medial margin slice 9 B. SLN #1 RIGHT AXILLA Received fresh is a tan pink lymph node 0.5 x 0.5 x 0.5cm. The specimen is sectioned and a touch prep is taken. Toto b1. C. SLN #2 RIGHT AXILLA Received fresh is a tan pink lymph node 0.8 x 0.6 x 0.6cm. The specimen is sectioned and a touch prep is taken. Toto C1. D. SLN #3 RIGHT AXILLA Received fresh is a tan pink lymph node 0.9 x 0.5 x 0.5cm. The specimen is sectioned and a touch prep is taken. Toto D1. E. SLN #4 RIGHT AXILLA  Received fresh is a tan pink lymph node 0.6 x 0.6 x 0.5cm. The specimen is sectioned and a touch prep is taken. Toto E1. DIAGNOSIS: A. BREAST, RIGHT, WIDE LOCAL EXCISION: - INVASIVE DUCTAL CARCINOMA. SBR GRADE 2, MEASURING 1.7-CM, INVOLVING SKELETAL MUSCLE - INTERMEDIATE NUCLEAR GRADE, DUCTAL CARCINOMA IN SITU, CRIBRIFORM TYPE - SURGICAL RESECTION MARGINS NEGATIVE FOR TUMOR - BIOPSY SITE CHANGES WITH FIBROSIS AND GRANULATION TISSUE - SEE SYNOPTIC REPORT. B. LYMPH NODE, SENTINEL #1, RIGHT AXILLA, EXCISION - ONE LYMPH NODE, NEGATIVE FOR METASTASES (O/1). C. LyMPH NODE, SENTINEL #2, RIGHT AXILLA, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (O/1) D. LYMPH NODE, SENTINEL #3, RIGHT AXILLA, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1).
+
+--- Page 2 ---
+E. LYMPH NODE, SENTINEL #4, RIGHT AXILLA, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (O/1). SYNOPTIC REPORT - BREAST Specimen Type: Excision Needle Localization... Yes - For mass Laterality:  Right Invasive Tumor: Present Multifocality: No WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Tumor stze: 1.7cm Tumor Site: Not specified Margins: Negative Distance from closest margin: 0.3cm inferior Tubular Score: 2 Nuclear Grade: 2 Mitotic Score: 2  Modified Scarff Bloom Richardson Grade: : Necrosis: Absent Vascular/Lymphatic Invasion:  None identified Lobular neoplasia: None Lymph nodes: Sentinel lymph node only. Lymph node status: Negative 0/4 DCIS present Margins uninvolved by DCIS DCIS Quantity:Estimate 1% DCIS Type: Cribriform DCIS Location:Associated with invasive tumor Nuclear grade: Intermediate Necrosis: Absent ER/PR/HER2 Results ER: Positive PR: Positive HER2: Pending Performed on Case: Pathological staging (pTN): pT 1c N 0 CLINICAL HISTORY: None provided.  PRE-OPERATIVE DIAGNOSIS:E None provided. INTRAOPERATIVE CONSULTATION:S A. GROsS ExAmINATION: WLE right breast- 1.9cm mass 0.7cm from closest deep margin. Diagnosis called to Dr. at by Dr. TPB-TPC-TPD-TPE: Negative for carcinoma. Diagnosis called to Dr. at .. by Dr. ADDENDUM: SYNOPTIC REPORT - BREAST HER-2 RESULTS Specimen:  Surgical Excision Block Number: A9 Interpretation: EQUIvOCAL Intensity: 2+ % Tumor Staining: 20% Fish Ordered: Yes , on Date.  METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Her2 analysis was performed using the FDA approved Dako HercepTest (TM) test kit ) using rabbit anti- human HER2. This assay was not modified. External kit-slides provided by the manutacturer (cell lines with high, low and negative HER2 protein expression) and in-house known HER2 amplified control tissue were evaluated along
+
+--- Page 3 ---
+with the test tissue. Adequate, well preserved, clear-cut invasive carcinoma was identified for HER2 evaiuation. Interpretation of the HER2 immunohistochemical stain is guided by published results in the medical literature,. information provided by the reagent manufacturer and by internal review of staining performance. This assay has been validated according to the 2007 joint recommendations and guidelines from ASCO and CAP  and from the NCCN HER2 testing in Breast Cancer Task Force. The Pathology Department takes full responsibility. for this test's performance.. PathVysion HER-2 DNA Probe Kit Case No Analytical Interpretation of Resuits: HER-2 NOT AMPLIFIED Clinical Interpretation of results. Amplification of the HER-2 gene was evaluated with interphase fluorescence in-situ hybridization (FISH) on formalin-fixed paraffin embedded tissue sections using a chromosome 17 centromeric probe and a HER-2 probe that spans the entire HER-2 gene in the Pathology Core Facility by Dr. A majority of tumors cells displayed 2 chromosome 17 signals and 2 HER-2 signals, with a HER-2/CEP 17 Ratio </=2.0, consistent with no amplification of the HER2/neu gene.. Block used  A9 Source of case: Tissue fixation formalin-fixed tissueOutside Case No: NA Tissue source breast Results interpreted: yes HER2/CEP17 ratio: 1.02 This ratio is derived by dividing the total number of LSi HER-2/neu signals by the total number of. CEP17 signals in at least 20 interphase nuclei with nonoverlapping nuclei in the neoplastic. mammary epithelial cells. Ceils with no signals or with signals of only one color are disregarded. Method of ratio enumeration: manual count Limitations The Vysis PathVysion Kit is not intended for use to screen for or diagnose breast cancer. It is  intended to be used as an adjunct to other prognostic factors currently used to predict disease-free  and overall survival in stage Il, node-positive breast cancer patients. In making decisions regarding adjuvant CAF treatment, all other available clinical information should also be taken into. consideration, such as tumor size, number of invoived lymph nodes, and steroid receptor status. No. treatment decision for stage II, node-positive breast cancer patients should be based on HER-2/neu gene amplification status alone. Overview of this test FDA APPROVED REAGENT  PathVysion HER-2 DNA Probe Kit is FDA approved for selection of. patients for whom Herceotin theranv is heina considered. These tests were performed in the under the direction ot Dr. The results of these studies should always be interpreted in the context of the clinical, morphological, and immunophenotypic diagnosis. ONCOTYPE DX BREAST CANCER ASSAY RESULTS: Recurrence Score: 19 CLINICAL EXPERIENCE: Patients with a recurrence score of: 19 in the clinical validation study had an average. rate of Distant Recurrence at 10 years of 12% ER Score: 10.2  Positive PR Score: 8.8 Positive Her2 Score: 8.9 Negative Interpretation: er Negative < 6.5 Positive >= 6.5 PR  Negative < 5.5 Positive >= 5.5 Her2 Negative <10.7 Positive >=11.5 Eguivocal = 10.7 - 11.4 See separate report for further information. Test performed at: Gross Dictation: Microscopic/Diagnostic Dictation: Pathologist,. Final Review: Pathologist, Final: Pathologist, Addendum: Patholuyist, Addendum Final: Pathologist, Addendum: Pathologist, Addendum Final: Pathologist, Addendum: Pathologist, 1. Addendum Final: Pathologist, Diagno
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diff --git a/output/text/80600476-d985-4aa9-a8c5-4e5cd3918935.txt b/output/text/80600476-d985-4aa9-a8c5-4e5cd3918935.txt
new file mode 100644
index 0000000000000000000000000000000000000000..187567fd0758c83f5e3268be675840ec3b36a036
--- /dev/null
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+This report is for inquiry only. The authorized report is available in the Department of Pathology. Patlent Information Female y.o.) Result Information Edited Entry Date Resuit Narrative SURGICAL PATHOLOGY REPORT Patient Name: Path No.: Med. Rec. #:  client: THD DOb/Gender: J(Age: F Collected: Received: Soc. Sec. #: Reported: Hosp #: Physician(s) : 1cd-0-3 Pre-Operative/Clinical History. eafcin0ma,10bu!ar, infi1:Ha+ng Right breast CA 85z0J 3 Specimen(s) Received A: RIGHT BREAST NIPPLE MARGIN (SUTURE - DUCTS ADJACENT TO NIPPLE) 3-3o 1Z RO B: LEFT BREAST, SUTURE = AXILLARY TAIL C: RIGHT BREAST, STITCH MARKS AXILLARY TAIL Gross Description Specimen A, received fresh for frozen section labeled right breast nipple margin, suture = duct adjacent to nipple, consists of a 2.0 x 1.3 x 0.3 cm nar+ion of skin. The specimen is entirely submitted for frozen section in I. Specimen B, received in formalin labeled left breast, suture = axillary tail. Specimen type: Simple mastectomy without axillary tail or pectoralis muscle.. The anterior aspect is. inked yellow, the apparent nipple site is inked blue, the posterior/deep margin is inked black and the anterior lateral aspect is inked orange for orientation purposes. Specimen size/description:. 16.0 cm ML x 11.5 cm SI x 2.7 cm AP, 205 gm. Laterality: Left. Cut surfaces: The cut surfaces are comprised. of approximately UUID:07833A91-F827-4708-AECC-728C708F8E2D TCGA-AC-A3QQ-01A-PR Redacted
+
+--- Page 2 ---
+85% of markedly dense fibrous tissue to 15t of adipose tissue that is predominantly at the periphery. A discrete lesion is.not grossly identified. Detached within the container is a small unremarkable fibroadipose tissue fragment that is 4.0 x 2.5 x 0.6 cm. Nipple/areolar complex: Absent. The apparent nipple site is inked blue. Skin: Absent. Lymph node sampling: None identified. Representatiye sections as follows: (B1 Nipple site (blue), perpendicular section (B2), 3) Upper outer quadrant (B3 questionable lymph node bisected, inked yellow) (B4, 5) Upper inner quadrant (B6, 7) Lower outer quadrant (B8, 9) Lower inner quadrant (B10) Detached fibroadipose tissue fragment. Specimen.C, received without fixative labeled right breast, stitch marks axillary tail. Specimen type: Simple mastectomy without axillary tail or pectoralis muscle. The anterior aspect is inked yellow, the posterior/deep margin is inked black and anterior lateral aspect adjacent to the suture is inked orange for orientation purposes. Specimen size/description: 16.5 cm ML x 12.0 cm SI x 2.8 cm AP, 205 gm. Laterality: Right. Tumor size: 1.7 x 1.5 x 1.3 cm. Tumor site: 12 o' clock position approximately 4.0 cm from the apparent nipple site.. Tumor description: Spiculated borders with a tan focaliy gritty rubbery cut surface surrounded by markedly dense fibrous tissue. There is a metallic clip centrally within the tumor. Deep margin (black): 0.2 cm. Nipple/areolar complex: Absent. The apparent nipple site is inked blue. Skin: Absent. Lymph node sampling: Not identified. Other: The remaining cut surfaces are comprised of approximately 90% of dense fibrous tissue to 10t of adipose tissue predominantly focused at the periphery. Representative sections as follows: (C1) Apparent nipple site (blue), perpendicular section (C2) Deep. margin (black) closest to tumor, perpendicular section (C3-6) Tumor (C7} Upper inner quadrant (C8) Upper outer 'quadrant.
+
+--- Page 3 ---
+(C9) Lower inner quadrant (C10) Lower outer quadrant. Total fixation time in formalin: 30.0 hours.. Intraoperative Consultation Specimen A, frozen section diagnosis of "no malignancy seen" is rendered by Dr. Microscopic Description Sections (Afl) demonstrate benign breast tissue including multiple large ducts. Neither atypical epithelial hyperplasia nor malignancy is seen. Sections (B1-b1o) demonstrate breast parenchyma with benign fibrocystic disease, apocrine metaplasia and benign intraductal epithelial hyperplasia. There is a benign intramammary lymph node (B3). Neither atypical epithelial hyperplasia nor  malignancy is seen. Sections (Cl, C7, Cl0) demonstrate breast parenchyma with benign fibrocystic disease and benign intraductal epithelial hyperplasia. Sections (c2) of breast demonstrate invasive lobular carcinoma associated with lobular carcinoma in situ. The invasive tumor cells demonstrate negative membrane staining for E-cadherin immunostain. The invasive carcinoma to adjacent inked deep margin distance (c2) is 1.5 mm.. Summary of Pathologic Findings Breast Carcinoma Specimen: Total breast.. Procedure: Nipple-sparing total mastectomy.. Lymph node sampling: None with current specimen. Previous right axillary sentinel lvmnh node biopsies Specimen integrity: Single intact specimen. Specimen size: 16.0 x 11.5 x 2.7 cm. Laterality: Right breast. Tumor site: 12 o'clock position. Size of invasive component: 1.7 x 1.5 x 1.3 cm. Tumor focality: Single focus of invasive carcinoma.. Macroscopic and microscopic extent of tumor:. Skin: Not present.. Nipple: Not present. Skeletal muscle: Not' present. Histologic type: Invasive lobular. Combined histologic grade: Printed by  Page'3 of 6
+
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+Tubule formation: Score 3. Nuclear pleomorphism: Score 2. Mitotic count: Score 1 (less than 1 mitoses per 10 hpf, hpf area 0.274 mm2).. Total Nottingham score: Score 6 (grade II). Lymph-vascular invasion: Absent. Ductal carcinoma in situ: Absent. Extensive intraductal component (EIc): Not applicable Extent: Not applicable. Lobular carcinoma in situ: Present. Deep margin:  Not involved. Invasive carcinoma to deep margin distance is 1.5 mm. Lymph nodes: No lymph nodes submitted with current specimen. The results of the previous right axillary sentinel lymph node biopsies are given below. Number of sentinel nodes examined: 5 Total number of nodes examined: 5 Number of nodes with macrometastasis: 0 Number of nodes with micrometastasis: Number of nodes with isolated tumor cells: 0 ( Size of largest metastatic deposit: Not applicable Extracapsular extension: Not applicable. Method of evaluation of sentinel lymph nodes:. Three 80 um interval H&E stained sections and two 80 um interval cytokeratin AE1/AE3 immunohistochemical stains on all sentinel lymph node blocks. TNM stage:. pTIc pNO(sn) (i-) pMX. Ancillary studies (estrogen receptor, progesterone receptor, HEr2/neu and Ki-67) : Performed on this specimen, results pending.. Microcalcification: Not identified. Diagnosis SPECIMEN A, RIGHT BREAST, NIPPLE MARGIN, EXCISIONAL BIOPSY: BENIGN BREAST PARENCHYMA. NO ATYPICAL EPITHELIAL HYPERPLASIA OR MALIGNANCY SEEN.S SPECIMEN B, LEFT BREAST, NIPPLE-SPARING TOTAL MASTECTOMY:  Printed by of 6
+
+--- Page 5 ---
+BENIGN FIBROCYSTIC DISEASE. BENIGN INTRADUCTAL EPITHELIAL HYPERPLASIA. SPECIMEN C, RIGHT BREAST, NIPPLE-SPARING TOTAL MASTECTOMY: INVASIVE LOBUALR CARCINOMA, GRADE II. LOBULAR CARCINOMA IN SITU. INVASIVE LOBULAR CARCINOMA CLOSESLY APPROACHES DEEP MARGIN (SEE) DESCRIPTION) . BENIGN FIBROCYSTIC DISEASE. M.D. ***Electronicaliy Reviewed and Signed Out By M.D. on Comment Positive and negative controls react satisfactorily. FDA required disclaimer: These tests were developed and their performance characteristics determined by They have not been cleared or approved by the U.s. Food and Drug Administration. The FDA has determined that. such clearance or'approval is not necessary. These tests are used for clinical purposes and should not be regarded as investigational or for research. This. laboratory is certified under the Clinical Improvement Amendments of 1988 (CLIA) as qualified to perform high complexity clinical laboratory testing.. College of American Pathologists (CAp) - required information for. predictive/prognostic markers: 1. Type of specimen fixation and detection. system: Tissue is fixed in 10s formalin. Indirect biotin-free detection kit is used. 2. Clones used: ER (clone 6Fl1) a; PR (clone PGR 636) t; cDll7 (polyclonal. I; HER2 (clone 4B5, FDA approved); Ki-67 .(clone K3, p53 (clone Do7, MSH6 (clone BC-44, ). MSH2 1e clone G219-1129), MLH1 (: clone G168- 728), PMS2 (clone MRQ-28, . 3. Criteria for positive results: ER and PR: >1t of tumor cells with nuclear staining; HER2: >30% of cells show. complete membrane staining; p53: >10t of tumor cells with nuclear staining;. Proteins: complete absence of tumor nuclear staining. CPT Code(s) A: B: c: Procedures/Addenda BREAST PANEL ADDENDUM Addendum Diagnosis IMMUNOHISTOCHEMICAL ASSAY RESULTS Immunohistochemical assays are performed on paraffin embedded sections' containing the invasive carcinoma and analyzed with computer assisted image analysis system. Results are as follows: ESTROGEN RECEPTOR: Positive, 3+ intensity, 99t of cells.. PROGESTERONE RECEPTOR:S Positive, 3+ intensity, 78t of cells.. Printed by Jf 6
+
+--- Page 6 ---
+HER-2 OVEREXPRESSION: Positive, 3+. Ki-67: Unfavorable (46%). Please see separate report for complete details of. analysis. Ki-67 proliferation index is reported as percent positive with less than or equal to 20% representing favorable prognosis category and greater than 20% representing unfavorable prognosis category. Her2 positivity requires greater than 30% of tumor cells showing complete membrane staining; score of 2+ is indeterminate (weak positive) and will be confirmed by Fish. A score of 3+ is strong positive. Only the strong positive (3+) Her2 shows strong concordance. with clinical trial results for Herceptin. Her2 scores of 0 and 1+ (faint incomplete staining) are considered negative. Criteria for ER/pR positive result: >1t of tumor cells with nuclear staining. Positive and negative controls react satisfactorily. Tissue is fixed in 10s formalin. Indirect biotin-free detection kit and high pH HieR are used. Antibody clones: Ki-67 (30-9,. , ER (clone Sp1, ), PR (clone. iE2, ), Her2 (clone 4B5, EDA approved). FDA required disclaimer: The immunohistochemical stain(s) is/are used for clinical purposes. The FDA has determined that such clearance or approval.is not necessary. It should not be regarded as investigational or for research. This laboratory is regulated under the Clinical Laboratory Improvement Amendments of 1988 (cLiA) as qualified to perform high complexity clinical testing. M.D. ***Electronically Reviewed and Signed Out By. , M.D.on Result History. PATHOLOGY GENERAL ORDER (Orde. n - Order Result History Report. a Order Providers Unknown, Provider Original Order Additlonal information View Encounter Priority and Order Details Collection Information, Page 6 of 6
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diff --git a/output/text/8085c005-4571-4e2f-a865-e5b347363753.txt b/output/text/8085c005-4571-4e2f-a865-e5b347363753.txt
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index 0000000000000000000000000000000000000000..007f3b26795b2c2c4a3e07bb2d24a8204e9464d2
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+
+--- Page 1 ---
+1cD-0-3 Carcioms,mf(tnshxy ductal, Nts 85oo/3 PaH Sit: Brast, soQ C5o,s 1/19/n C4cF Sit: Bruot,Nos c5o.9 hw 4. Jnvasive ductal breast carcinoma (max. diameter 2.2 cm, now also in some sections malignancy grade IIl) with angioinvasion in the immediate tumor periphery, also with concomitant high-grade DCIS (procomponent > 10). Distant fibrolipomatous parenchyma of the breast (with cystic duct ectasia) with risk lesions of unsettled to atypical ductal hyperplasia, but tumor-free. Minimal width of caudal and dorsal safety margin 0.7-0.8 cm. Histologically unremarkable skin spindle. Tumor classification: G3 (L1, V0), pT2, pN3a, MX, R0. Redacted
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diff --git a/output/text/80db4b2a-a834-4444-ac18-dfde0f5aa1d5.txt b/output/text/80db4b2a-a834-4444-ac18-dfde0f5aa1d5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..72441e3d826cc814f33a643b7d8c898a04cb620e
--- /dev/null
+++ b/output/text/80db4b2a-a834-4444-ac18-dfde0f5aa1d5.txt
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+
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+Diagnosis: Colon resection material includes a moderately differentiated colorectal type of adenocarcinoma, max. 3.8 cm in size, with infiltration of the pericolic fatty tissue and focal evidence of carcinomatous lymphangiosis. Tumor-free regional lymph nodes. Tumor-free colon resection margins. Tumor-free mesenteric resection margin Tumor stage: pT3 pN0 (0/24) pMX; G2 L1 V0 R0
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diff --git a/output/text/80e0b54a-40c3-4357-87a2-62aea043e4f8.txt b/output/text/80e0b54a-40c3-4357-87a2-62aea043e4f8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..46953a8388e414b2adb4cbebb8ff857f6ca46361
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+
+--- Page 1 ---
+Metastatre LN Patient:  Referring Physician: UUID:A92859DA-41AD-4CF9-86AF-E4073E6276ED TCGA-AC-A6IX-06A-PR Redacted DOB: Age: Gender:F Ref#: Hosp#: Provider Group : Date of Service: Date Received: Date Reported: A copy of this report will be faxed to: FInal SurgICaL PAthOLOgy REpORt Jc0-0-3 Diagnosis: 8Ka0/3 A. -B.) LEft breast, modifIed RaDICal mAstectomy: - Multicentric invasive lobular carcinoma, Nottingham grade 2. Sitt : 1ymph mode, axillay - Tumor size: 3.5 cm. c77.3 - Smaller tumor nodules: 0.1 to 1.2 cm in diameter. - Atypical lobular hyperplasia and atypical ductal hyperplasia. lw - Metastatic carcinoma in nineteen of twenty-one axillary lymph nodes (19/21) 3/5p4 - Largest metastatic focus: 2.5 cm; extranodal extension present. - One of the nodes was previously biopsied. - Mastectomy margins are free of tumor. - Carcinoma is 1 cm from the deep margin, and at least 1 cm from all other margins. PATHOLOGIC TUMOR STAGING SUMMARY: Type and grade (invasive): Invasive Iobular carcinoma, Nottingham grade 2. Primary tumor: pT2(m). Regional Iymph nodes: pN3a. Distant metastasis: Not applicable. Pathologic stage: IIIC. Margin status: Negative. COMMENT: The main tumor mass is Iocated in the 3-4:00 region of the breast, and grossly measures 3.5 cm in diameter. Adjacent to this nodule is a 1.2 cm secondary nodule. A third 0.5 cm nodule is identified in the lower inner quadrant, and small foci of invasive tumor are located in the subareolar breast tissue. The separately submitted lymph node (specimen B) is positive for metastatic carcinoma, and is included in the total Iymph node count above. Invasive Breast Cancer Tumor Staging Information AJCC Cancer Staging Handbook, 7th Ed., and CAP Protocol (revised June 2012). Previous pathology specimens Case # Printed: Page 1 This report continues. (FINAL) MR No. - Acct No. 'athology - Page 1/6 Patient Name - Dage 1 Doc#1
+
+--- Page 2 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT Case #. Page 2 Printed: This report continues.. (FINAL.) MR No. - Acct No. Patient Name Pathology - Page 2/6 : Page 2 Doc# 1
+
+--- Page 3 ---
+Patient: Case #: SPECIMEN IDENTIFICATION Procedure/specimen type: Modified radical mastectomy. Laterality: Lefl. Lymph node sampling: Lymph node dissection. INVASIVE CARCINOMA TUMOR CHARACTERISTICS Histologic type: Invasive lobular carcinoma. Tumor site: Main mass 3-4:00 aspect. Tumor size: 3.5 cm. Tumor focality: Multicentric. Histologic grade (Nottingham Score): 2 of 3. Tubule formation: 3 0f 3. Nuclear pleomorphism: 2 of 3. Mitotic rate: 1 0f 3. Lymphovascular invasion: Indeterminale. Macroscopic and microscopic extent of tumor: No skin or chest wall invasion is identified. DUCTAL CARCINOMA IN SITU (DCIS): Not identified. MARGINS Invasive carcinoma: 1 cm from deep margin, at least 1 cm from all other margins. LYMPH NODES Total lymph nodes examined 21. Number of lymph nodes involved 19. Size of largest metastatic deposit: 2.5 cm. Extranodal extension: Present around multipie Iymph nodes. PATHOLOGIC STAGING: Primary Tumor (pT): pT2(m). Regional lymph nodes (pN): pN3a. Distant metastasis (pM): Not applicable. AJCC Stage: IIIC. ANCILLARY STUDIES: Estrogen receplor: 98% positive cells, strong intensity. Progesterone receptor: Less than 1% positive cells, strong intensity. HER2: IHC score 1+. Ki-67: 5% positive cells. Case #: Printed: Page 3 This report continues. (FINAL) MR No Acct No. - 'athology - Page 3/6 Patient Name . Page 3 Doc#1
+
+--- Page 4 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT Source of Specimen: A. Breast;left B. Apical node Clinical History/Operative Dx: Left breast cancer. Gross Description: A. Received fresh labeled "modified radical mastectomy" is a right modified radical mastectomy. specimen. The breast measures 16 cm (medial-lateral) x 15 cm (superior-inferior) x 5 cm. (anterior-posterior), and weighs 538 g. There is an elliptical portion of tan skin measuring 15 x 8 cm, with.  nipple and areola present just medial of center. The attached axillary tail measures 10 x 4 x 1.5 cm. The specimen is inked as follows: Blue -- Superior,. Orange - Inferior,. Black - Deep. The specimen is sliced from medial to lateral in nine slices with slice 1 most medial, slice nine most  Iateral (including axillary tail). The nipple is in slice #4. There is a dominant mass in the 3-4:00 aspect of the specimen, approximately 5 cm from the nipple, measuring 3.5 x 3 x 2 cm. This mass is 2 cm from the closest inferior margin, 1 cm from the deep margin,. and is al least 4 cm from all other margins. A nodule is appreciated superior-posterior to lesion #1, 1.2 x. 0.8 cm, within slabs 4-5. There is a second ill-defined nodule iocated approximately 3 cm superior to the largest mass, located in. the upper outer quadrant, approximately 2 cm in diameter. A third ill-defined area of nodularity is identified in the upper inner quadrant measuring up to 2.5 cm in diameter, located in slabs 3-4, from Case #: Printed: Page 4 This report continues... (FINAL) MR No. .cct No "atient Name 'athology - Page 4/6 je 4 Doc#1
+
+--- Page 5 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT medial. In the lower inner quadrant, there is a 0.5 cm nodule, at ieast 1 cm from the nearest margin.. There is ill-defined nodularity in the lower outer quadrant region, apart from the main turnor, and areas of central fibrocystic changes. The axillary tail contains prominent Iymph nodes, the largest of which is 2.5 cm in diameter. Portions of lumor and non-tumor breast tissue, and a portion of the suspicious lymph node are submitted for research. Time removed from breast:. Time placed in formalin: Representative sections are submitted,according to the following slide key:. A1) nipple (slab 4), A2) medial and lateral extension of skin represented, A3) lower outer quadrant, A4) lesion #1, lower outer quadrant, A5) lesion #1, overlying skin, A6) lesion #1, deep margin relationship, A7) lesion #1, lower outer quadrant, adjacent inferior superficial surgical margin, slab 6,. A8) lesion #1, slab 7, A9) lower outer quadrant, adjacent to lesion #1, slab 8,. A10-A11) discrete bilobed nodularity, superior to lesion #1, slabs 4-5, respectively.. A12) second (#2) ill-defined mass, slab 5, A13) second ill-defined mass, slab 6, A14) second ill-defined mass, superior edge, slab 7.. A15) deep surgical margin adjacent to second ill-defined mass,. A16) superior superficial surgical margin adjacent to second ill-defined mass, slab 6,. A17) upper outer quadrant, slab 8, A18) third nodule, upper inner quadrant, adjacent to second ill-defined mass, slab 4, adjacent deep margin separate piece,. A19) upper inner quadrant, third nodular area, slab 3,. A20) upper inner quadrant, deep surgical margin, adjacent to third nodular area suspicion, slab 3,. A21) upper inner quadrant, superficial surgical margin adjacent to third nodular area of suspicion, slab 3,. A22) upper inner quadrant, adjacent to third nodular area. slab 1,. A23) lower inner quadrant, slab 2,. A24) central breast - subareolar area, siab 4,. A25) discrete nodule, lower inner quadrant, A26-A27) largest lymph node, A28) four lymph nodes,. A29) five iymph nodes, A30) two lymph nodes bisected, one marked orange,. A31) two lymph nodes bisected, one marked orange,. A32) larger and smaller lymph node, each bisecled, one marked orange,. A33) single lymph node bisected, A34) single lymph node bisected. A35) single lymph node bisected B. Part B designated apical node. Received is a single pink-gray, dense gray lymph node candidate, 1.3 x. 0.7 x 0.5 cm. The node is submitted in its entirety, bisected in B1. Case #. Printed: Page 5 This report continues... (FINAL) MR No. Acct No. 'athology - Page 5/6 tient Name - Page 5 Doc# 1
+
+--- Page 6 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT Microscopic Description: A. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered. B. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered. This is A metrotrHe 1y^ph rorle. J.3/314 Case # Printed:  Page 6 END OF REPORT (FINAL) MR No Acct No. Patient Nam 'athology - Page 6/6 Page 6 Doc# 1
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diff --git a/output/text/80e43c5e-8e0f-4c3a-a4a3-0b74982bfa80.txt b/output/text/80e43c5e-8e0f-4c3a-a4a3-0b74982bfa80.txt
new file mode 100644
index 0000000000000000000000000000000000000000..35306f8e0d1c202adff9be219fc34b5bbbe6ac7f
--- /dev/null
+++ b/output/text/80e43c5e-8e0f-4c3a-a4a3-0b74982bfa80.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+ICD 6-3 Carsiuom,psyeillary rnol 824013 SURGICAL PATHOLOGY C64.9 Accession #: Collected: Received: yO n/za/l3 ADDENDUM Addendum Comment A TTF-1 immunohistochemistry stain performed on section #10 of the renal tumor is negative. The control is appropriate. The diagnosis remains unchanged. This immunohistochemistry test(s) was developed and its performance characteristics determined by the . It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA. has determined that such clearance or approval is not necessary. This test. is used for clinical purposes. It should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory. Improvement Amendments of 1988 (CLIA) as qualified to perform high complexity clinical laboratory testing. End of Addendum Report or Additional Results UUID:C21AC32C-3D4D-4942-AFDB-5F237985D552 TCGA-MH-A855-01A-PR Redacted Staff Pathologist PATHOLOGIC DIAGNOSIS KIDNEY, RIGHT, NEPHRECTOMY: - PAPILLARY RENAL CELL CARCINOMA, TYPE 1 - 12.1 CM IN THE LARGEST DIMENSION - FUHRMAN GRADE 3 - LIMITED TO KIDNEY - EXTENSIVE NECROSIS - NO SARCOMATOID TRANSFORMATION - NO LYMPHOVASCULAR OF LYMPHATIC INVASION - MARGINS FREE Tumor Staging (Pathology) Anatomic site of cancer: Right kidney Histologic type: Papillary renal cellc carcinoma Fuhrman grade: 3Tumor size (cm): 12.1 cm in the largest dimension Primary tumor (T): T2b Lymph node (N): NX Distant metastasis (M): MX Stage grouping: Stage II Site of distant metastasis: Not known
+
+--- Page 2 ---
+Surgical margins: Free Comment: The finding was communicated via secure email with Staff Pathologist Intraoperative Consultation Kidney, right, nephrectomy: - Tumor identified (gross only) - Verbally reported to at Staff Pathologist Pathology Resident Pertinent Clinical Information History of right renal mass Gross Description Specimen Material: Right kidney Received fresh for intraoperative consultation, labeled "RIGHT KIDNEY" is a 621 gm, 14.5 x 12.2 x 7.5 cm right nephrectomy specimen containing a 13.7 x 11.2 x 7.3 kidney with a 1.3 cm in length x 0.3 cm in diameter ureter, a 0.8 cm in length x 0.3 cm in diameter artery with a 0.4 cm in length x 0.5 cm in diameter vein. There is abundant attached adipose tissue. No adrenal gland is identified. The Gerota's fascia margin is inked black. The cut surface shows a 12.1 x 9.4 x 4.6 cm yellow to black and hemorrhagic mass involving 85% of the kidney which is located 0.3 cm from the inked margin and does not appear to be involving the attached fat, is 4.5 cm from the artery, vein, ureter, and is 2.6 cm from the renal pelvis. The mass is 95% solid and 5% cystic. The urothelium is gray-white and smooth. The remaining kidney parenchyma is beefy red and gray-brown and the corticomedullary junction is well-defined. The cortex measures 1.4 cm thick. No lymph node is identified. Representative sections are submitted as follows: 1 vascular and uretal margins 2-4 mass to inked margin 5-18 mass-1 block per cm to landmark-pelvis, fat, normal parenchyma 19 cortex and medulla
+
+--- Page 3 ---
+Pathology Assistant Pathology Resident Microscopic Description This is a papillary renal cell carcinoma with extensive tumor necrosis. No. sarcomatoid transformation, perineural or lymphovascular invasion is seen.. Tumor is confined to the kideny. Vascular and uretral margins are negative. The staff pathologist listed below has reviewed this case **Electronically Signed Out** Staff Pathologist
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diff --git a/output/text/80e9f9a2-b36b-4102-b0fe-c1068c5ecc0c.txt b/output/text/80e9f9a2-b36b-4102-b0fe-c1068c5ecc0c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a4301bf87ae16d6e720d551e1509393a0ecd6ece
--- /dev/null
+++ b/output/text/80e9f9a2-b36b-4102-b0fe-c1068c5ecc0c.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+icd - 0-3 Catmoma,hnfiltnah`ng duct, N0S 8500f3 C 50.9 Sife Cd: b^east, NOS 1s|>fo iw Final diagnosis. east, right, total mastectomy: Infiltrating ductal carcinoma, Nottingham grade III (of IIl), forming a 3.1 x 2.3 x 2.1 cm mass in. the medial portion of the breast (AJCC pT2)." Extensive angiolymphatic invasion is present. The surrounding breast parenchyma shows proliferative fibrocystic changes characterized by sclerosing adenosis with associated calcifications. Nipple and skin are without diagnostic abnormalities. All surgical resection margins including the deep margin, are negative for tumor (minimum tumor free margin, 6 mm, deep margin). Skeletal muscle present and not involved by tumor. See comment.. Lymph nodes, separately submitted right axillary No.1 and No.2, excision: A single (of 2) right axillary lymph node is positive for micrometastatic (1 mm) carcinoma, present on frozen section only (AJCC pN1mi).. Lymph nodes, right axillary, dissection: Multiple (7) right axillary lymph nodes are negative for tumor.. Soft tissue, right axillary low region, excision: Fibroadipose tissue. No lymph node tissue or tumor identified.. Comment:Estrogen: Focally positive, 1-10% nuclear staining. Progesterone: Negative, 0% nuclear staining ER (Estrogen Receptor) test was developed and its performance characteristics determined by. It has not been cleared or approved by the U.S. Food and Drug Administration..  HER2/neu protein overexpression is negative, score of 0, according to the interpretation guidelines in the FDA-approved. HercepTest. UUID:75F29A17-B6AF-43B9-BE12-3ABF850F23BA TCGA-AR-A1AH-01A-PR Redacted
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diff --git a/output/text/80f0ee65-3e4a-427a-ae4b-ce2b80dbe0d3.txt b/output/text/80f0ee65-3e4a-427a-ae4b-ce2b80dbe0d3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6176f5eebdf479184279bf485daf2f4af1e5bb6e
--- /dev/null
+++ b/output/text/80f0ee65-3e4a-427a-ae4b-ce2b80dbe0d3.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+ICD-O3 NS Pathology Report FINAL Yo7d/3 Report Type Patholoav Report Date of Event Sex . Authored by Hosp/Group hJ 8/a113 FINAL Record Status FINAL DIAGNOSIS: PART 1: TONGUE BASE, BIOPSY INVASIVE SQUAMOUS CELL CARCINOMA. PART 2: LYMPH NODES, RIGHT NECK LEVELS 2-4, SELECTIVE DISSECTION A. METASTATIC SQUAMOUS CELL CARCINOMA IN THREE OF TWENTY-THREE LYMPH NODES (3/23); POSITIVE LYMPH NODES IN LEVELS 2 AND 3. B. LARGEST LYMPH NODE 5.5 CM (MATTED) LEVEL 2 WITH EXTRANODAL EXTENSION. PART 3: LYMPH NODES, LEFT NECK LEVELS 2-4, SELECTIVE DISSECTION A. FOURTEEN LYMPH NODES, NO SQUAMOUS CELL CARCINOMA PRESENTS (0/14). B. METASTATIC PAPILLARY THYROID CARCINOMA IN ONE LEVEL 4 LYMPH NODE; NO EXTRANODAL EXTENSION. PART 4: BASE OF TONGUE, RIGHT MARGIN, EXCISION NO TUMOR PRESENT. PART 5:  LARYNX, TOTAL LARYNGECTOMY A. INVASIVE SQUAMOUS CELL CARCINOMA, MODERATELY TO POORLY DIFFERENTIATED,  SUPRAGLOTTIC (4.5 CM), LEFT AND RIGHT WITH PRE- EPIGLOTTIC SPACE AND VALLECULAR INVOLVEMENT. UUID:A7817114-11F4-45C4-9559-78E392A40505 B. PERINEURAL INVASION PRESENT. TCGA-CN-A6V3-01A-PR Redacted c. MARGINS FREE (SEE ALSO OTHER PARTS). D. PATHOLOGIC STAGE: pT3 N2b. PART 6:  PYRIFORM, RIGHT, EXCISION NO TUMOR PRESENT. Pathologist: ** Report Electronically Sianea By Pathologist: My signature is attestation that I have personally reviewed the submitted material(s) and the final diagnosis reflects that evaluation. GROSS DESCRIPTION: Specimen is received unfixed in six parts. Part 1 is labeled with patient's name, initials xx and "tongue base biopsy". It consists of a 1.5 x 0.6 x 0.2 cm tan-red soft tissue evaluated intraoperatively. The remainder of the specimen is submitted labeled 1AFS. Formalin exposure time: 34 hours
+
+--- Page 2 ---
+Part 2 is labeled with the patient's name, initials xx and "right levels 2 thru 4". It consists of a 13.0 x 4.5 x 1.0 cm portion of soft, yellow-. red, hemorrhagic and focally cauterized fibroadipose tissue exhibiting one bulging nodule (5.5 x 3.5 x 1.5 cm) present within level II. The cut surface is firm, tan-white, lobular and solid. The specimen is divided into levels 2 thru 4. In addition to the dominant level II nodule, multiple soft to moderately firm, tan-gray to pink-red lymph nodes ranging 0.3 to 2.0 cm in greatest dimension are identified on dissection. Representative dominant level II nodule submitted to the Ink Code: Green- external surface of suspicious nodule. Section code: 2A-c- level II, dominate nodule, representative sections. 2D-F- lymph nodes, level II 2G- level III lymph node, (1 bisected). 2H-J- level III lymph nodes 2K- level IV lymph nodes Formalin exposure time: 30 hours. Part 3 is labeled with the patient's name, initials xx and "left neck. dissection levels 2 thru 4". It consists of an unoriented 8.0 x 3.7 x 0.9 cm portion of yellow and lobular fibroadipose tissue and red-brown muscle. The specimen is arbitrarily divided into segments A, B and C. Multiple tan- pink to gray, soft lymph nodes ranging 0.3 to 2.3 cm in greatest dimension are identified on dissection.. Section code: 3A-B- lymph nodes, segment A 3C- lymph nodes, segment B 3D-E- lymph nodes, segment c (each one bisected). 3F- lymph nodes, segment C Formalin exposure time: 30 hours Part 4 labeled with the patient's name, initials xx and "right base of tongue margin". It consists of a 3.5 x 0.4 x 0.3 cm tan-red soft tissue. evaluated intraoperatively. The remaining tissue is submitted labeled 4AFs. Formalin exposure time: 30 hours Part 5 is labeled with the patient's name, initials xx and "total larynx". It consists of a total laryngectomy 9.7 x 7.2 x 4.5 cm, 4.6 x 1.3 x 0.9 cm attached hyoid bone, three tracheal rings and a moderate amount of anterior soft tissue and muscle.. There is a 4.5 x 2.3 x 1.8 cm (depth), well-defined, moderately firm, tan-white, focally hemorrhagic, exophytic supraglottic lesion involving the
+
+--- Page 3 ---
+right aspect of epiglottis, base of the epiglottis, right false vocal cord and anterior commissure. The ventricle is compressed but grossly the right true vocal cord is uninvolved. On cross-section the lesion penetrates. through the epiglottis invading the para epiglottic fat, coming to within 0.8 cm of the base of tongue mucosal resection margin, 1.0 cm from the anterior soft tissue margin, 0.3 cm from the right aryepiglottic mucosal margin and 4.0 cm from the third tracheal ring margin. The left false and true vocal cords are smooth, soft, pliable and grossly uninvolved. The remaining laryngeal mucosa is smooth, tan-pink-red and mildly. edematous in the glottic region. The thyroid cartilage is unremarkable.. Digital images are taken. The right supraglottic lesion is procured for the clinical tissue bank. Ink code: Black- anterior soft tissue surgical resection. Yellow- soft tissue underlying hyoid bone. Green- base of tongue mucosal margin Red- banked area Section code: 5AFs- radial mid line base of tongue, frozen section. 5B-tracheal ring margin 5D- base of tongue 5E- anterior soft tissue margin, shave 5F- left aryepiglottic mucosal margin, shave 5G- supraglottic lesion in relation to tip of epiglottis. 5hdR- lesion in relation to anterior commissure 5I-5L-lesion in relation to right false cord, ventricle and true vocal cord (midline to lateral) 5M- left false and true vocal cords, uninvolved Formalin exposure time: 30 hours Part 6 is labeled with the patient's name, initials xx and "right pyriform". It consists of a 1.8 x 0.8 x 0.4 cm smooth, pink-gray, soft mucosa and underlying soft tissue entirely submitted labeled 6A.. Formalin exposure time: 30 hours GROSSED BY: INTRAOPERATIVE CONSULTATION: 1AFS: TONGUE BASE BIOPSy (frozen section)- A.  SUFFICIENT FOR ANCILLARY STUDIES B. MALIGNANT c. INVASIVE NON-KERATINIZING SQUAMOUS CELL CARCINOMA D. / 4AFS: RIGHT BASE OF TONGUE MARGIN, BIOPSY (frozen section)- A. SUFFICIENT FOR ANCILLARY STUDIES B. BENIGN
+
+--- Page 4 ---
+C. NO TUMOR 5AFS: LARYNX, LARYNGECTOMY (RADIAL MIDLINE BASE OF TONGUE) (frOZen section) - A. SUFFICIENT FOR ANCILLARY STUDIESS B. MALIGNANT C. MARGIN IS FREE MICROSCOPIC: Microscopic examination substantiates the above diagnosis. The following statement applies to all immunohistochemistry, Insitu Hybridization Assays (Ish & FIsh), Molecular Anatomic Pathology, and Immunofluorescent Testing: The testing was developed and its performance characteristics. determined by the as required by the CLIA '88 regulations. The testing has not been cleared or approved for the. specific use by the U.S. Food and Drug Administration, but the FDA has determined such approval is not necessary for clinical use. Tissue. fixation ranges from a minimum of 2 to a maximum of 84 hours. This laboratory is certified under the Clinical Laboratory Improvement Amendments of i988 ("cIA") as qualified to perform high-complexity clinical testing. Pursuant to the requirements of cLiA, AsR's used in this. laboratory have been established and verified for accuracy and precision. Additional information about this type of test is available upon request. CASE SyNopSiS: SYNOPTIC DATA - LARYNX RESECTIONS TYPE OF LARYNGECTOMY: Total TUMOR LATERALITY: Right, Left, Midline TUMOR LOCATION/SEGMENT: Supraglottic TUMOR SIZE: Maximum dimension: 4.5 cm HISTOLOGIC TYPE OF TUMOR: Squamous cell carcinoma HISTOLOGIC GRADE: Poorly differentiated/Undifferentiated. STRUCTURES INVOLVED BY TUMOR: False cord, Epiglottis, Vallecula-. base of tongue, Pre-epiglottic space LYMPH NODES: Lymph nodes positive, Right: 3 Total number of right sided lymph nodes examined: 23 Lymph nodes positive, Left: 0 Total number of left sided lymph nodes examined: 14 EXTRACAPSULAR SPREAD OF LYMPH NODE METASTASES Yes INTRA-PERINEURAL INVASION: Present VASCULAR INVASION: Yes SURGICAL MARGIN INVOLVEMENT: Free (2 mm or more) T STAGE, PATHOLOGIC: Supraglottis, pT3 N STAGE, PATHOLOGIC: pN2b M STagE, PATHOLOGIC: pMX Comment: one left level Iv lymph node shows metastatic papillary thyroid carcinoma NO KNwn pier thyr+r canuv rr testment, proR OCR + Tc6A tvmer procurrnnt.
+
+--- Page 5 ---
+PATIENT HISTORY: CHIEF COMPLAINT/PRE-OP/POST-OP DIAGNOSIS:  Laryngeal cancer. PRoceDuRE: Total laryngectomy. SPECIFIC CLINICAL QUESTION: Not answered. OuTsIDE TIssuE DIAgnosIS: Not answered. PRIOR MALIGNANCY: Not answered. ChemOrADIatIOn: Not answered. ORGAN TRANSPLANT: Not answered. IMMUNOSUPPRESSION: Not answered. OTher DiseAses: Not answered. HISTO TISSUE SUMMARY/SLIDES REVIEWED:S Part l: Tongue Base Biopsy Taken: Received: Stain, Block HHE x 1 AFS H&E x 1 AFS Part 2: Right Levels 2-4 Taken: Received: Stain/ Block H&E x 1 H&E B H&E x c H&E x D H&E x 1 E H&E x F H&E x G H&E x H H&E X I H&E x 1 J H&E x K IMSU x 1 (none) Part 3: Left. Neck nissection Levels 2-4 Taken: Received: Stain, BloCk H&E x 1 H&E x 1 B H&E x 1 c H&E x 1 D E H&E H&E x 1 F Part 4: Right Base of Tongue Margin. Taken: Received: Stain/. Block H&E x 1 AFS Part 5: Total Larynx Taken: Received: Stain/ Block H&E x B H&E x c H&E X D H&E x E H&E x F H&E X G H&E x I H&E x J H&E x 1 K H&E x  : L
+
+--- Page 6 ---
+H&E x 1 M H&E x 1 AFS Decal x 1 HDR H&E x 1 HDR IMSU x 1 (none) Part 6: Right Piriform Taken: Received: Stain/: Block H&E x 1 A TC1 M 7/4/13
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diff --git a/output/text/80fe270d-c288-4ea7-a7d8-c309afd2ebdb.txt b/output/text/80fe270d-c288-4ea7-a7d8-c309afd2ebdb.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1d4e2c32868f7a48f98f7c374aaecda0c2912739
--- /dev/null
+++ b/output/text/80fe270d-c288-4ea7-a7d8-c309afd2ebdb.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+CCD D-2 UUID: B34668F2-C885-426D-9DDC-C310C8DF9616 877113 TCGA-V4-A9F1-01A-PR Redacted bat Lluesltiset C4.y AJ x/wli4 Enucleation of the right eye.  Macroscopy The eyeball mesures 22 mm in diameter with a segment of optic nerve of 8 mm. At the section, a pigmented blackish nodule measuring 17X12 mm. The specimen has been included entirely. Microscopy The tumor observed macroscopically presents the histological aspect of an uveals. melanoma. This tumor is composed mainly of epithelioid cells, more rarely fusiform (<1%). The cell atypias are severe. The pigmented load is mild. The mitotic activity is low (2 mitosis per 10 HPF). There is a focal tumor extension on the inner part of the sclera, without extra-scleral exteriorisation. The optic nerve and the anterior chamber are free of tumor. Conclusion Uveal melanoma of the right eye Tumor size: 17 mm main line. Focal tumor infiltration of the inner part of the sclera, without extra-scleral extension. Optic nerve free of tumor.
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diff --git a/output/text/8103e287-5093-40de-9b02-a99e4f41b44f.txt b/output/text/8103e287-5093-40de-9b02-a99e4f41b44f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..39289798da5b79bc4dde9e017e4467e48c6d617c
--- /dev/null
+++ b/output/text/8103e287-5093-40de-9b02-a99e4f41b44f.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+ICs-0 - 3 UUID:ED2D1BA8-8FE8-43E1-9174-91F9D59565F9 Redacted 1A-PR carcinoma mfi!trsHrq ouct,Nos 85oof3 Sits: sraot, Nos c50.9 Breast, left, wide-local excision: Invasive ductal adenocarcinoma, Nottingham grade III (of III), forming a mass 2.3 x 2.0 x 2.0 cm (AJCC pT2). Ductal carcinoma in-situ, high nuclear grade, solid type comprises 10% of the tumor. The surgical margins are negative for tumor. Lymph nodes, left axillary sentinel, excision: A single (1) left axillary sentinel lymph node is positive for tumor (AJCC pN1mi). No blue dye identified. Lymph nodes, left axillary, excision: Multiple (3) left axillary lymph nodes are negative for tumor (AJCC pN0). Estrogen: Positive, > 10% nuclear staining Progesterone: Focally Positive, 1-10% nuclear staining ER (Estrogen Receptor) test was developed and its performance characteristics determined by . It has not been cleared or approved by the U.S. Food and Drug Administration.
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diff --git a/output/text/812969bd-f0d0-4459-9642-c5fe286a28c3.txt b/output/text/812969bd-f0d0-4459-9642-c5fe286a28c3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..daa3980d5bdca863e5a1383a519339eac183fb6d
--- /dev/null
+++ b/output/text/812969bd-f0d0-4459-9642-c5fe286a28c3.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+OPER CATE: PROCEDURE: APMI ADDENDUM TO REPORT CHANGE IN MARGIN STATUS AFTER DISCUSSION WITH SURGEON: Please see revised template and revised diagnosis below. ADRENOCORTICAL CARCINOMA V4 UUID: 8D4E0E4D-9C84-4F29-AFD9-91EEEC158ED6 TCGA-OR-A53Y-01A-PR Redacted Tumor Size: 17.1 x 12.5 x 10.3 cm. Tumor weight: Cannot determine. Capsular Invasion: Yes. Vascular Invasion: Yes.. ICD-6 -3 Surgical Margins: Negative.. Necrosis: 75% (gross). 83713 Mitotic Rate: 60/50 hps. Site: AdreroI Glard,eortex. High. C 74.D Grade: 9>1|3s113 Lymph nodes status: 1/2. Extra-adrenal extension: Present.. Stage: 4 (pT3 N1 M1). Immunohistochemistry Results: N.A. PROCEDURE: APDX 2. Right adrenal and kidney, resection: High-grade adrenocortical carcinoma (17.1 cm) with capsular and extensive vascular invasion, including invasion of vasa cava. Margins negative. Please see TemPlATe for details. Metastatic carcinoma in one of two tymph nodes (1/2). Incidental renomedullary interstitial cell tumor. 1 and 3. Please see previous report for diagnoses which remain unchanged. the signing staff pathologist, have personally eu the slides from this case.
+
+--- Page 2 ---
+PREVIOUS DIAGNOSIS INQUIRY REPORT DAIE PAGE#: 3 Sex: BIRTHDATE: PAT TYPE: ADM DATE: OPER DATE: OPER DATE: PROCEDURE: SPHS History of anemia and right upper quadrant pain. PROCEDURE: SPGD 1. "Right liver surface nodule, rule out metastatic cancer." Received fresh for frozen section is a 0.5 x 0.5 x 0.3 cm, tan nodule. 1A. Frozen section control. 2. "Right adrenal gland and kidney." Received in formatin in a large container. is a radical nephrectomy specimen (1585 gm), consisting of: kidney (11.7 x 7.5 x 6.2 cm), adrenal tunor (17.1 x 12.5 x 10.3 cm). vena cava (1.5 x 1.8 cm), renal vein (3.2 x 2.6 cm), renal artery (3.9 x 0.5 cm), ureter (5.7 x 0.4 cm) and attached perirenal/periadrenal adipose. The vena cava is remarkable for an exophytic tunor thrombus, which extends 5.7 cm past the margin of resection. The adrenal tumor is inked blue and sectioned to reveal. yellow-brown, variegated and friable cut surfaces remarkable for extensive areas of hemorrhage and necrosis (75%). The adrenal tumor is encapsulated within a thin, intact membrane. No normal adrenal parenchyma is identified. The adrenal tumor abuts the superior pole of the kidney, however, no involvenent is identitied. Found within the renal medulla of the mid pole is a. 0.4 x 0.3 x 0.3 cm, gray, well-circunscribed nodule. The remaining renal. parenchyma is unremarkable. The perirenal/periadrenal adipose, renal vein, renal artery and ureter are uninvolved and unremarkable. There are multiple possible lymph nodes up to 2.1 cm in greatest dimension. This case has been consulted with 2A. Vena cava margin inctuding tumor thrombus. 2B. Renal vein, renal artery and ureter margins. 2c. Two possible lymph nodes submitted whole. 2D. Ore possible lymph node, serially sectioned. 2E. Ore possible lymph node, serially sectioned. 2F-1. Adrenal tumor including capsule. 2J-K. Center of adrenal tumor. 2L. Acrenal tumor to kidney. 2M. Renal nodule.
+
+--- Page 3 ---
+ PREVIOUS DIAGNOSIS INQUIRY REPORL DAIE: PAGE #: 4 SEX: F BIRTHDATE: PAT TYPE: ADM DATE: OPER DATE: 3. "Costochondral cartilage." Received in formalin in a small container is a 2.7 x 1.8 x 0.9 cm soft tissue and bone excision, including two embedded ribs,. 1.7 cn segments each, and surrounded by grossly unremarkable skeletal muscle and fibrous tissue. No lesions are present. Specimen subnitted for gross examination only. FROZEN SECTION REPORT 1. Positive for metastatic carcinoma.  have reviewed and interpreted the frozen section material at the time it was requested. PROCEDURE: SPMI ADRENOCORTICAL CARCINOMA V4 Tumor Size: 17.1 x 12.5 x 10.3 cm. Tumor Weight: Cannot determine. Capsular Invasion: Yes. Vascular Invasion: Yes. Surgical Margins: Positive (vena cava and soft tissue). Necrosis: 75% (gross). Mitotic Rate: 60/50hpf. Grade: High. Lymph nodes status: 1/2. Extra-adrenal extension: Present. Stage: 4 (pT3 N1 M1) Imnunohistochemistry Results: N/A
+
+--- Page 4 ---
+ PREVIOUS DIAGNOSIS INQUIRYE REDORt DATE: PAGE#: SEX: F BIRTHDATE: PAT TYPE: ADM DATE: OPER DATE: PROCEDURE: SPDX 1. Liver, right surface nodule, biopsy: Metastatic carcinoma. 2. Right adrenal and kidney, resection: High-grade adrenocortical carcinoma (17.1 cm) with capsular and extensive vascular invasion, including invasion of the vena cava. Carcinoma present at vena cava margin and focally at soft tissue margin. See TEmPlATe. Metastatic carcinoma in one of two lymph nodes (1/2). Incidental renomedullary interstitial cell tunor. 3. Bone and soft tissue, "costochondral cartilage", resection: Unremarkable bone and soft tissue. Gross only.. the signing pathologist, have personally examined. and interpretea tne slides from this case. *********** ** END OF PREVIOUS D1AGNOSIS INQUIRY **
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+/cs-0-3 carciiono, nfilt^atrg duct. nos 8s"oo13 Site. bunot,Nos C 5Ur9 4/12/4 page 1 / 2 Department of Cancer Pathology copy No. Date: :. Examination: Histopathological examination. Examination No.: Patient: XXX PESEL: XXX Age: Gender: F Material: 1. Multiple organ resection - left breastwith axillary tissues. Lritrra Unit in charge:  Physician in charge: Material collected on: Material received on: Expected time of examination: upto 8 working days Clinical diagnosis: Cancer of the left breast. Examination performed on: Macroscopic description: Left breast sized$21 x 18 x 3 cm removed along with axillary tissues sized 10 x 5 x 2 cm and a 15 x 6 cm skin flap. Weight 520-g Tumour sized 1.9 x 1.6 x 1.7 cm in the middle part, 1.5 cm from the upper boundary, 1.6 cm from the base and 0 cm from the skin. Microscopic description:. Carcinoma ductale invasivum - NHG2 (2+3+2/10 mitoses/10 HPF - visual area: 0.55mm). Foci of carcinoma ductale in situ (Dcis) found within the tumour (solid and cribrate type, with medium nuclear atypia, without necrosis and with calcifications of below 5% of the tumour). Infiltratio carcinomatosa mamillae. Focus of carcinoma ductale invasivum found in the glandular tissue (inner lower quadrant - diameter 0.1 cm). Also showing also lesions of the type mastopathia fibrosa et cystica, hyperplasia ductalis simplex (uDH). AXILLARY LYMPH NODES:E Metastases carcinomatosae in lymphonodis (No VI/xvill). Infiltratio capsulae lymphonodi. Preliminary result: Final response to be given after whole of the material is analysed. Compliance validated by: Examination performed on: .. Results of immunohistochemical examination: Estrogen receptors found in over 75% of neoplastic cell nuclei. Progesterone receptors found in over 75% of neoplastic cel nuclei. HER2 protein stained with HercepTestTM by DAKO. Negative reaction in invasive cancerous cells ( Score = 1+ ) Compliance validated by:. Examination performed on: UUID:D5614445-4EBF-4050-8FC6-D34D5CAADD82 TCGA-D8-A1XD-01A-PR Redacted
+
+--- Page 2 ---
+page 2 / 2 Examination: Histopathological examination Exdmnanon No.: PEseL: XXX Gender: F Patient: XXX Examination performed on: Histopathological diagnosis: Carcinoma ductale invasivum bifocal et ductale in situ mammae sinistrae.  Invasive ductal bifocal carcinoma and ductal in situ carcinoma of the left breast. Metastases carcinomatosae in Iymphonodis axillae (No VI/xvll) (NHG2, pT1c, pN2a) Cancer Metastases in axillary lymph nodes. Compliance validated by: CONTACT YOUR DOCTOR WITH THIS REPORT!
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diff --git a/output/text/814cc5e4-6c2c-4be9-a6d5-15e4af364e10.txt b/output/text/814cc5e4-6c2c-4be9-a6d5-15e4af364e10.txt
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+Received Date/Time Final Reporting Information Date/Time : Final Updated Histopathologist : Laboratory : DIAGNOSIS (AFS) 'Left submandibular mass': Poorly preserved tumour involving fibrofatty connective tissue. The immunomorphologic features. are consistent with diffuse large B-cell lymphoma.. (B) Left submandibular gland: (i) Involvement of fibrofatty connective tissue and lymph node by diffuse large B-cell lymphoma.. (ii) Mild chronic sialadenitis; no malignancy. seen. (iii) Fragment of normal thymus. FROZEN SECTION DIAGNOSIS (AFs) Left submandibular gland:. Gland is infiltrated by undifferentiated tumour.. lymphoma to be defined. GROSS DESCRIPTION (AFs) Received fresh is a tissue mass measuring 3 x 2.5 x lcm which is serially cut into 4 pieces, two of which are snap-frozen for storage and the remainder fixed in formalin for histological sampling.. (Alfs; no reserve) (B) Received in formalin is a specimen labelled with patient's data and designated "left submandibular gland". It consists of a submandibular gland and 3 additional irregular pieces of tissue. The submandibular gland measures 4.8 x 3.4 x 2cm. The 3 pieces of tissue measure 2.5 x 1.5 x 0.5cm, 2 x 1 x 0.5cm and 1 x 1.5 x .0.7cm respectively. The external surface of the submandibular gland is inked orange. Cut sections of the submandibular gland show normal appearance. No solid nodules are visible grossly. Some whitish nodular ill-defined areas are present in' the smaller pieces.. (B1 to B4-rer resentative sec ions of the salivary gland, B5 & B6-remaining 3 pieces) MICROSCOPIC DESCRIPTION (AFs) Paraffin section of the frozen section specimen confirms fibrofatty connective tissue infiltrated by malignant tumour. Unfortunately in most areas, there is suboptimal preservation and many cells also show individual necrosis. There are numerous degenerate cells with presence of scattered pyknotic nuclear debris and interspersed macrophages. There is also diathermy and traumatic crush artefact. In areas where cells are better preserved, they appear to form sheets, and have enlarged pleomorphic vesicular nuclei, many containing prominent central nucleoli. No gland formation is seen.. (B) Submandibular gland examined shows patchy mild chronic inflammation only. The separately received smaller specimens comprise fibrofatty connective tissue and residual lymph node infiltrated by sheets of tumour cells of similar appearance to that described for. Immunostains demonstrate lesional cells to be positive with cDi0, bcl-6, muM-1 and CD20. Cyclin Dl, TdT, bcl2, AEl/3 and Sl00 are negatiye. CD3 highlights interspersed small T-lymphocytes. MIBl is positive in approximately 90% of the tumour population. No dendritic meshworks are identified. Also represented is separate normal thymic tissue.. (For your attention).
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diff --git a/output/text/81588427-8e7e-49f0-b28b-97b09967cf03.txt b/output/text/81588427-8e7e-49f0-b28b-97b09967cf03.txt
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index 0000000000000000000000000000000000000000..d414dab8788e6db80bc04ad733d23703dba97859
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+IcD-0 - 3 Cascinomr,nif4tnithy ductal N0s 85vof3 C50.9 Stte bjeist,Nos 3/1+ page 1 / 1 Department of Cancer Pathology Examination: Histopathological examination Examination No.:  Patient: PESEL: Age: Gender: F Material: Multiple organ resection -- left breast Unit in charge: Physician in charge: Material collected on: . Material received on: Expected time of examination: up to 8 working days Clinical diagnosis: Cancer of the left breast -- lesion in the upper outer quadrant. Examination performed on: :. Results of immunohistochemical examination: Estrogen receptors found in 75% of neoplastic cell nuclei. Progesterone receptors found in 75% of neoplastic cell nuclei. HER2 protein stained with HercepTest" by DAKO. Negative reaction in invasive cancerous cells (Score = 1+ ) Compliance validated by: Examination performed on:. Macroscopic description: Left breast sized 20 x 13 x 2 cm removed without axillary tlssues. Skin flap 20 x 9.5 cm in size. Tumour sized 1.7 x 1.8 x 1.5 cm found on the boundary of outer quadrants, placed 2 cm from the lower edge, 0.2 cm from the base and 1.0 cm from the skin. Cysts of 0.1 -- 0.5 cm In the cross- section. Microscopic description: Carcinoma ductale invasivum NHG1 (2+2+1 /1 mitosis /10 HPF, vision area diameter 0.57 mm) Additionally, focuses of carcinoma ductale in situ: cribrate type with medium nuclear atopia, no  necrosis, found in the glandular tissue (30% of the tumour cross-section). Glandular tissue showing lesions of the type: mastopathia fibrosa et cystica, adenosis sclerosans, fiat epithelial atypia ( FEA). fibrocystic changes, sclerosing adenosis Histopathological diagnosis:. (including test No. G-I5785/10): Carcinoma ductale invasivum et in situ mammae sinistrae. (NHG 1, pT1c, pN0/sn/). Invasive and in situ ductal carcinoma of the left breast UUID: B5074D1A-C617-414F-B349-6096F59E122D Compliance validated by: TCGA-D8-A13U-01A-PR Redacted
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diff --git a/output/text/817a7b24-d209-4a67-b4d3-af356a06f124.txt b/output/text/817a7b24-d209-4a67-b4d3-af356a06f124.txt
new file mode 100644
index 0000000000000000000000000000000000000000..03c9332b25a0c8fec2037329a5bb51115f951aa5
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+
+--- Page 1 ---
+UUID:728F4C58-5ES5-4810-AC7A-0E144A498593 TCGA-UZ-A9PL-01A-PR Redacted SURGICAL PATHOLOGY REPORT Patient Name! Accession #:. Med. Rec.#: Visit #: Service Date: DOB: Sex:  Male Received: Soc. Sec. #: Location:: Client: Physician(s): FInal Pathologic DIagnosis. Kidney and adrenal: 1. Renal cell carcinoma, papillary (chromophil) type, Fuhrman grade 2, 10 cm in. diameter, closest approach to anterior superior fascial inked margin >0.1 cm.. 2. Distal ureteral and vascular resection margins, free of tumor.. 3. Adrenal gland, no tumor seen. Comment: Kidney tumor Kidney Tumor Synoptic Comment. TD-03 -Histologic type: Renal cell carcinoma, papillary (chromophil) type. -Grade: Furhman grade 2. Coureinsmi, ylpIlre Maximum tumor diameter: 10 cm. -Site within kidney: Upper pole. Nnal cIl 8Q6d3 -Renal pelvis: Normal. -Ureter: Normald Sute OBiey NtS -Renal sinus: Normal, no tumor. -Hilar renal veins: Normal, no tumor. C649 -Intrarenal veins and lymphatics: Normal, no tumor tO3|3o|14 -Adrenal gland: Normal. -Capsule/perirenal fat: Tumor penetrates capsule with gross tumor in perirenal fat. -Hilar lymph nodes (number positive/number of nodes): 0/0. -Resection margins: No tumor identified.. -Proximity to nearest margin: > 0.1 cm at anterior superior fascial inked margin [slide A4[ -Stage: pTN,Mx. Specimen(s) Received A:Kidney and adrena!  Page 1 of 2
+
+--- Page 2 ---
+Clinical History. The patient is a  -year-old man with a left renal mass. Gross Description The specimen is received in formalin in one part, labeled with the patient's name, medical record number, and "left kidney." It consists of a nephrectomy specimen, weighing 1078 gm and measuring 19.0 cm from superior to inferior, 13.0 cm from medial to lateral, and 7.0 cm from anterior to posterior. The specimen is. received bisected, with the external fatty surface marked with black ink. Additional sagittal sections of the specimen are also noted upon manipulation. The cut surface of the sectioned specimen shows a ragged, soft, yellow, necrotic tumor, measuring 10.0 cm, which appears to be circumscribed; this is situated at the superior pole of the kidney. On further inspection, the tumor appears to abut on the renal cortex and does not involve the adjacent renal medulla, renal pelvis or calices. Cut section of the renal pelvis and renal. sinus shows no tumor involvement in this area. Search for lymph nodes is performed within the renal hilum/renal sinus area, and no lymph nodes are identified. Gross inspection of the sagittal sections of this. tumor shows that the nearest approach to the external inked surface of the perirenal adipose tissue is 0.3 cm at the superior-anterior region. The ureter is identified and measures approximately 3.5 cm in length. and O.5 cm in diameter. The renal vessels are also identified. The ureter and vascular resection margins are grossly free of tumor. The adrenal gland is identified and measures 5.0 x 2.0 x 1.0 cm. The tumar does not involve the adrenal gland grossly. The kidney is red-brown and normal in shape; it measures 12.0 x 5.0 x 3.0 cm and the renal capsule strips with ease. Additional transverse sections of the specimen shows no other tumor lesions. Representative sections of the specimen are submitted as follows: Cassette A1: Ureteral margin (en face). Cassette A2: Vein and artery surgical resection margins (en face). Cassette A3: Adrenal gland. Cassette A4: Tumor at its nearest approach to the perirenal fat at the anterior-superior area. Cassettes A5-A6: Sections of tumor in relation to the kidney cortex, medulla, and calices. Cassette A7: Superficial cortex and tumor interface. Cassette A8: Additional cortex and tumor interface at mid kidney. Cassettes A9, A10: Full thickness section of kidney with tumor interface (bisected) Cassette Al1: Full thickness section of kidney with tumor interface (bisected) Diagnosis based on gross and microscopic examinations. Final diagnosis made by attending pathologist following review of all pathology slides. Pathology Resident athologist Electronically signed out on? V 12342s13 Page 2 of 2
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index 0000000000000000000000000000000000000000..28a3896c9be8d7d76a5bd89ec1cc9642f8fa79dd
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+UUID:317C24E3-3F0F-4685-AC67-FF1F687C9087 TCGA-BB-A5HU-01A-PR Redacted SURG PATH REPORT Qrcinomo, sguamous Csll 0 807013 Site: Orol Cavity co6.9 FINAL DIAGNOSIS pathologist: 1. ANTERIOR MANDIBULAR MARGIN (EXCISION):  NEGATIVE FOR TUMOR. 2. POSTERIOR MANDIBULAR MARGIN (EXCISION): NEGATIVE FOR TUMOR. AJ 1/Q8/13 3. MEDIAL MUCOSAL MARGIN (EXCISION) : NEGATIVE FOR TUMOR. 4. ANTERIOR MUCOSAL MARGIN (EXCISION) : NEGATIVE FOR TUMOR. POSTERIOR BUCCAL MUCOSA MARGIN (EXCISION) : NEGATIVE FOR TUMOR. 6. ANTERIOR BUCCAL MUCOSA MARGIN (EXCISION): NEGATIVE FOR TUMOR. 7. POSTERIOR MUCOSA MARGIN (EXCISION) : NEGATIVE FOR TUMOR. 8. SKIN,. FQREHEAD (EXCISION): .BASAL.CELL CARCINOMA (NODULAR VARIANT, 0.SCM). MARGINS ARE UNINVOLVED. 9. COMPOSITE ORAL CAVITY: SPECIMEN TYPE: Resection (specify type): Partial mandibulectomy.. TUMOR SITE: Oral cavity (right mandible). TUMOR SIZE: Greatest dimension: 4.5cm. HISTOLOGIC TYPE: Carcinomas of upper aerodigestive tract: squamous_cell.carcinoma, conventional. HISTOLOGIC GRADE: G2: Moderately differentiated. EXTENT OF INVASION (7th Edition AJCC): PRIMARY TUMOR (pT):) pT4: Tumor invades through cortical bone.. REGIONAL LYMPH NODES (pN) : pN2b: Metastasis in muitiple ipsilateral lymph nodes.. Specify: Number examined: 37 Number involved: 6 Extracapsular extension of nodal tumor:. Present. MARGINS : Margins uninvolved by tumor. VENOUS/LYMPHATIC (LARGE/SMALL VESSEL) INVASION: Indeterminate. PERINEURAL INVASION: Present. ADDITIONAL PATHOLOGIC FINDINGS: LEVEL 1: METASTATIC SQUAMOUS CELL CARCINOMA INVOLVING 5 OF 7 LYMPH NODES. 10. RIGHT NECK LEVELS 2, 3, 4 (NECK DISSECTION):) *** Unofficial lab results - do not file in patient chart. *** UINLESS OTHERWTSE NOTED ON THE DETAIL PAGE, ALL LAB RESULTS PERFORMED AT: Page 1 of 2
+
+--- Page 2 ---
+LEVEL 2: METASTATIC SQUAMOUS CELL CARCINOMA INVOLVING 1 OF 13 LYMPH NODES. TUMOR DEPOSIT MEASURES 1.5CM. LEVEL 3:  6 LYMPH NODES AND ASSOCIATED FIBROADIPOSE TISSUE, NEGATIVE FOR TUMOR. LEVEL 4: 11 LYMPH NODES AND ASSOCIATED FIBROADIPOSE TISSUE, NEGATIVE FOR TUMOR. has reviewed key parts of this case. *** Unofficial lab results - do not file in patient chart. *** UNLESS OTHERHISE NOTED ON THE DETAIL PAGE, ALL LAB RESULTS PERFORMED AT: Page 2 ot 2 iscir
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diff --git a/output/text/81a1bc8a-4a14-4268-960f-aacfab9d6593.txt b/output/text/81a1bc8a-4a14-4268-960f-aacfab9d6593.txt
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index 0000000000000000000000000000000000000000..f2015abc8279ec58d0cbf307b4faca6979ca420a
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+PATHCLOCKO ANOSIS SPETTMENDRHNATE "IEFT ROCAL NEPHRHCOMY CARA. 6.c Fha ncear grade y ory d tocal y through Gerotu's faecia a e ked Ceroa's fanal mnrg and rena_ vein arcin. Rena. artery wrccr margins are segaivo for .uor. iasio  q.ad, neqative A.ansitca.on: TN.MX .we., Patho.cgy Sorvico has revewod tie Case and con.rn RENAE PAHC CY RVAJATION CF KIDNEY PARMNCHYMA: HEPTKISHEY, NEPHRECTOMY MINMA,CHRONIC CHANGES OF THE KDNRY PARENCHYMA,MOS IKEIY A-RHATEDSEENCTE ANTERIAL AND ARTEROLAR SCLEROSISMUSHH NOTC NOTE: The kincy paronchyaa sumled showe min.ca honie cnangce. Where emld u.oeleei ia. HICROSCOIDWSCRPTON Sericns Fomain-t=xed, parafti crhocdod slssue ock Als wore cn.ated sing He.PAs,Jones svcr methenuine and Ar trichrome sans The san ccx ad aiuld. Trorare49g.cueri prso. wh.... . .he cegugia. Rad ha o se ccral paeneyu s.cw b.a atrophy sd inte grco seros he rea and o CLIN.CAL.DATA: Hscry: None given Tersior I.radical nsphrectony. recloral 1ymgh soe siese.ion perarive Findinge: None given in- A . ROSACESCRITK
+
+--- Page 2 ---
+Pathology Report ci  rocerosh arcedwith thpasionrs namewn numbor asd corniets c. .4979 eft nephrectomy spccinen, g88.5 .5 and .8. and sorronding per ronal ayur.nq 9a81 Hxtending tat possblo ren e. h.eng.. .8 c in ciarcter n diametcr caly and posib.e renal There 6.5 x122.5 . tan/gnk/ro/yo.low el.arcync. multpl arcan o r0020s18 nonorrrage, kidncy with catelie nodn es iat oant three n tne surrcunding agi fro hc ikrd margin ad Coro fas 1.50. cx.enng  the ureter 3.cm Te tuor markedly rr.tc arcral wieh ccntains mu.sl an/ined s r The na la ac rxemarka.c Representatve scctiona ot tho ytoqn and Tisoue Bank and ma isoene repree. s bak a fer eleren ..crogcopy and imanotiworcscent st.adies. Four possibe _contfied at. Tumor nodulcn in perirera fu and inkei deep Trei  n porrenn. fa to anked margn and Gerou's Riarr A Miarn kdnoy, dncy cagsne ana cror sodle in porreral fat. recr, 2 cnorma k.dnay reral yen MCO AE Reral yen and uret A9A Ti RS3twn Micro A1: ro A O A5 Sra 1ymph noccs Taross xn f  stated reledrcre
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diff --git a/output/text/8242d9ab-6658-4ddd-a92b-253cdbf034c9.txt b/output/text/8242d9ab-6658-4ddd-a92b-253cdbf034c9.txt
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index 0000000000000000000000000000000000000000..96a1c0f9b67e2b0cb042263cb510bfb4c93cd993
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+
+--- Page 1 ---
+UUID:A55C12D4-B4C2-4C04-8BE5-18B003B418C7 TCGA-09-A75Z-01A-PR Redacted Surg Path Final Report * Final Report * ICD O-3 'ercinono, cpapollsry renal * Final Report * eeQQ 8Q60/3 O YudneyNo S Sule Surg Path Final REpOrt C649 SURGICAL PATHOLOGY 8/Q/I3 Collected: Accession: Physician: PROCEDURE Left robotic partial nephrectomy. HISTORY Left renal mass GROSS Received fresh, labeled "left renal mass," is a 3 x 3 x 3 cm, 12-gram partial nephrectomy. The surgical margin is marked with black ink. The loosely attached fat is marked with green ink. Cut section shows a 2.5 x 2.5 x 2 cm yellow to hemorrhagic mass.  The mass is well-circumscribed and is contained with in the renal capsule. It is 0.1 cm to the black-inked surgical margin and 0.3 cm to the green-inked circumferential surface. A sample of the tissue is submitted for research studies per protocol. Tissue submitted for the TcgA research study. Representative sections submitted in five cassettes. Sections are taken as follows: 1-2 as tumor with green-inked circumferential surface 3-5 as tumor with black-inked surgical margin Total time in 10% neutral buffered formalin from collection through processing: 34.5 hours. Total cold ischemia time: 15 minutes. DIAGNOSIS KIDNEY CANCER PROFILE SPECIMEN TYPE: PARTIAL NEPHRECTOMY (LEFT). CLINICAL/WORKING STAGE: N/A Printed by: Page 1 of 3 Printed on: (Continued)
+
+--- Page 2 ---
+Surg Path Final Report * Final Report *. TISSUE COLD ISCHEMIA TIME: 15 MINUTES. TISSUE DURATION IN 1O PERCENT NEUTRAL BUFFERED FORMALIN: 34.5 HOURS. TUMOR SITE: MIDDLE POLE. FOCALITY: UNIFOCAL. TUMOR SIZE: 2.5 x 2.5 CM HISTOLOGIC TYPE: PAPILLARY RENAL CELL CARCINOMA. SARCOMATOID FEATURES: ABSENT. HISTOLOGIC GRADE: N/A EXTENT OF INVASION: TUMOR CONFINED TO RENAL PARENCHYMA. LYMPH-VASCULAR INVASION: ABSENT. COAGULATIVE NECROSIS OF TUMOR: NEGATIVE. MARGINS: RENAL PARENCHYMAL MARGIN INVOLVED BY TUMOR ALONG A 5 MM LINEAR DIMENSION. REMAINING MARGINS FREE OF TUMOR. LYMPH NODES:  NO LYMPH NODES PRESENT. ONLY A SMALL RIM OF PATHOLOGIC FINDINGS IN NON-NEOPLASTIC KIDNEY: NORMAL PARENCHYMA IS PRESENT, WHICH SHOWS MILD INTERSTITIAL NEPHRITIS LIKELY RELATED TO ADJACENT TUMOR. DISTANT METASTASIS: NOT APPLICABLE. CANCER STAGE: pT1a, pNX Note: Immunostains demonstrate that the tumor cells are positive for CK7 and racemase, but negative for cD1o. The results support the diagnosis. Page 2 of 3 Printed by: (Continued) Printed on:
+
+--- Page 3 ---
+Surg Path Finat Report * Final Report * 88307, 88342 x3 (Electronic Signature) Completed Action List:. * Order by on Type: Surg Path Final Report. Date: Status: Auth (Verified) Title: Surg Path Final REpORt Encounter info:. Contributor system: Printed by: Page 3 of 3 Printed on: (End of Report) M fa9f DISQUALIFIEC
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diff --git a/output/text/8245b3d4-86de-495e-9dd2-ccbde10f0074.txt b/output/text/8245b3d4-86de-495e-9dd2-ccbde10f0074.txt
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index 0000000000000000000000000000000000000000..c23fd19aa327c546d0fd93637869a8f6bd9aaed0
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+
+--- Page 1 ---
+page 1 / 2 Department of Cancer Pathologye Date: Examination: Histopathological examination (cito). Internal invoice No. Cost of diagnostic procedure. Examination No.: Patient: XXX PESEL: XXX Age: Gender: F Material: Multiple organ resection -- right brea with axillary tissues. Jcs-0-3 Unit in charge: : caciomn, nf(mtmg duct,nos 85vo]3 Physician in charge: S.ta: srnet Material collected on:. Material received on: Expected time of examination: S working days Clinical diagnosis: Examination performed on: Macroscopic description: Right breast, sized 24.8 x 19.3 x 5.2 cm, removed with axillary tissues sized 8.0 x 7.5 x 3.0 cm and a skin flap of 28.6 x 14.6 cm. Tumour sized 2.2 x 1.7 x 2.4 found in the lower outer quadrant, located 5.2 cm from the lower boundary, 1.7 cm from the base and 0 cm from the skin.. Microscopic description Carcinoma ductale invasivum NHG3 (3+3+2: 10 mitoses/10 HPF - visual area 0.55 mm). Mamillae sine laesionibus.. Glandular tissue showing parenchymal atrophy. Axillary lymph nodes:. Lymphonodulitis chronica (No VII).. Histopathological diagnosis:. Carcinoma ductale invasivum mammae dextrae. Invasive ductal carcinoma of the right breast.  (NHG3, pT2, pNO). Examination performed on:.  Results of immunohistochemical examination: Estrogen receptors found in over 75% of neoplastic cell nuclei. Progesterone receptors found in less than 10% of neoplastic cell nuclei. HER2 protein stained with Ventana's Pathway HER-2/neu (485) rabbit antibody. Score=2+, FISH verification recommended.  UUID:4ACD42D6-9520-4DC6-BB40-9187A4D499810 Redacted TCGA-D8-A1Y2-01A-PR 1
+
+--- Page 2 ---
+Examination: Histopathological examination (cito) paye 2 / 2 Examination No.: Patient: XXX pesel: Xxx Gender: F Examination performed on: . Result of immunohistochemical examination: RESULT OF HER2/neu GENE AMPLIFICATION with the FISH method by Path Vysion HER2 DNA Probe Kit FINAL RESULT: HER-2 GENE AMPLIFICATION NOT FOUND Compliance validated by: CONTACT YOUR DOCTOR WITH THIS REPORT
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+
+--- Page 1 ---
+Patient Name: Accession #: Med. Rec. #: Date of Procedure: DO8: Date of Receipl Gender. Date of Report Ref. Physician: Account #: Patient Address: Billing Type Additionat Copy to. Ref. Sourco: Clinicat Diagnosis & History: Right upper pole renal mass solid. Specimens Submitted: 1: SP: Kidney. right; partial nephrectomy (fs). 2: SP: Right kidney, deep surgical margin: oxcision DIAGNOSIS: 1.SP: Kidney, right; partial nephrectomy ((s):. Tumor Type:  Renal cell carcinoma - Papillary type Type 2 Tumor Size: Greatest diameter is 3.4 cm tocal Invasion (lor renal cortical types): Not Identified Renal Voin Invasion: Not identified Surgical Margins: Free of tumor Non Neoplastic Kidney: Focal conpression rolated changes. Adrenal Gtand: Not identified Lymph Nodes: Nol identified Staging for renal cell carcinoma/oncocytoma:. pT1 Tunor <= 7.0 cm in grealest dimension limlod to the kidney 2. SP: Right kidney, deep surgical margin; excision: Benign unremarkable renal parenchyma, confirmed by a PAS stain. TATIEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION QF THE SLIDES (ANDIOR OTMER MATERIAL). AND THAT IHAVE REVIEWED ANO APPROVED THIS REPORT Page 1 o1 2
+
+--- Page 2 ---
+Spocial Studies: Result Special Stain Comment PAS Gross Description: 1). Tho spocimon is received fresh and is labeled *Right renal lumor stitch marks deep surgical margin' It consists ol a 4 0 x 3.5 x 2.1 cm wedge shaped portion of kidney with a sulure marking the deep margin. There is a portion of fat atlached to the superior surface of the cortex. The margin is inked black and the specimen is serially sectioned to reveal a solid green mass measuring 3.4 x 3.0 x 2.5 cm. The clearanco from tho resection margin is 0.7 cm. A representativo section of the nearest margin is submilted for. frozen section diagnosis. Representatively submilted. Portions of the tumor are submilled for TPs. Photographs are taken.. Sunmary of sections: FSC - frozen section control T - tumor  M - margin 2). The specimen is received in formalin, labeled "Deep surgical margin of right kidney" and consisis of a 1.6 x 1.0 x 0.6 cm. fragment of lan soft tissue, consistont with kidney tissue.. Bisocled and enlirely submitted Summary ot sections: U-undesignated Summary of Sections: Part 1: SP: Kidney, right; partlal nephrectomy (fs). Block Sect. Site pCs 1 FSC 1 2 M 2 5 T 5 Part 2: SP: Right kidney, deep surgical margin; excislon. Block Sect. Site PCs 1 U 2 Intraoperative Consultation: Note: Tho diagnoses given in this section portain only to tho tissue sample examned al the time of tho inlraoperalive. consultation. 1 FROZEN SECTION DIAGNOSIS:  SP: RIGHT RENAL TUMOR (FS):  RENAL. CORTICAL NEOPLASM; AREA DESIGNATED BY STITCH IS NEGATIVE FOR TUMOR PERMANENT DIAGNOSIS: SAME Page 2 of 2 END OF REPORT
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diff --git a/output/text/82c0b149-68ae-403a-adee-2c5763c67ca8.txt b/output/text/82c0b149-68ae-403a-adee-2c5763c67ca8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c42ef9b5bac1d7a329af2c0aacd6049c394cecc7
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+--- Page 1 ---
+SPECIMENS: A. LIVER NODULE B. RIGHT COLON SPECIMEN(S): A. LIVER NODULE B. RIGHT COLON GROSS DESCRIPTION: A. LIVER NODULE Received fresh for frozen section is a tan pink soft tissue fragment 0.3cm. Toto FSA. B. RIGHT COLON Received is a segment of right colon measuring 19.0 cm long with average circumference of 7.0 cm. Its. proximal end is still attached to the terminal ileum (4 cm long with a 3.0 cm circumference). The appendix is 6 cm long with a 0.6 cm diameter. There is a cecal mucosa based mass, 7cm from the terminal ileum margin and 11 cm from the distal colonic margin. Both margins are free of tumor or any. additional findings. The mass is exophytic, tan color, with a rolled edge, which is sharply defined from the adjacent mucosa. The mass is also circular and measures 4.0 cm in diameter and < 1 cm in depth. (limited to muscularis propria on cross sectioning). On the radial aspect, black ink was applied. The mesocolon attached is grossly unremarkable, and measures approximately 1-5 cm in thickness. The remaining ileal and colonic mucosa shows no significant pathology. Summary of blocks: B1: terminal ileum margin B2: distal colon margin. B3-B10: tumor B11: appendix with bisected tips and complete cross section and small lymph nodes B12: contains fat nearest to the tumor invasion area, which is inked black - also contains lymph nodes B13-B20: possible nodes DIAGNOSIS: A. LIVER, NODULE, BIOPSY: - MINIMALLY ATYPICAL EPITHELIOID CELL PROLIFERATION.  SEE COMMENT - NEGATIVE FOR COLORECTAL CARCINOMA B. RIGHT COLON, HEMICOLECTOMY:  INVASIVE, MODERATELY DIFFERENTIATED ADENOCARCINOMA WITH FOCAL MUCINOUS FEATURES. TUMOR INVADES INTO SUBSEROSAL TISSUE - SURGICAL MARGINS ARE FREE OF TUMOR  SEE TEMPLATE - FIFTEEN LYMPH NODES NEGATIVE FOR CARCINOMA (0/15) COMMENT: The liver nodule shows a proliferation of relatively bland epithelioid cells separated by a fibrovascular stroma. Unfortunately, the tissue is largely absent on permanent sections and can only be. seen well on the frozen section. Ancillary studies like IHC are not possible. The epithelioid cells may represent histiocytes or potentially a hyperplastic mesothelial proliferation. There is no evidence of carcinoma, and I favor a benign process in this nodule. Correlation with clinical findings is recommended.  Microsatellite instability testing has been ordered on the colon tumor. Those results will be issued in a separate report. SYNOPTIC REPORT - COLON & RECTUM Specimens Involved Specimens: B: RIGHT COLON Specimen Type: Right hemicolectomy Tumor Site: Cecum Tumor Configuration: Exophytic (polypoid) Infiltrative Tumor size: 4cm
+
+--- Page 2 ---
+WHO Classification Adenocarcinoma 8140/3 Histologic Grade: G2: Moderately differentiated Extent of Invasion: Subserosa Margins: Margin(s) uninvolved by invasive carcinoma (Proximal, Distal, Radial) Distance of invasive carcinoma from closest margin: 7cm Margin: Proximal Venous/Lymphatic Invasion:. Absent Perineural Invasion: Absent. Additional Pathologic Findings: None identified Extent of Resection:  R0: Complete resection with grossly and microscopically negative margins Lymph Nodes: Negative 0 / 15 Implants: Absent  Pathological Staging (pTNM):  pT 3 a/b N 0 M X CLINICAL HISTORY: None provided. PRE-OPERATIVE DIAGNOSIS: Colon carcinoma. INTRAOPERATIVE CONSULTATION: FSA: No evidence of metastatic adenocarcinoma proliferation of atypical epithelioid cells and vessels. Favor benign lesion. Defer to permanent. This case was reviewed by Dr. who concurs with the diagnosis. ADDENDUM: SUMMARY OF IMMUNOHISTOCHEMISTRY/SPECIAL STAINS Material: Specimen B Population: Tumor Cells Stain/Marker:Result:  Comment:. MLH1 Positive MSH2 Positive PMS2 Negative MSH6 Positive The interpretation of the above immunohistochemistry stain or stains is guided by published results in the medical literature, provided package information from the manufacturer and by internal review of staining performance and assay validation within the Immunohistochemistry Laboratory of the. The use of one or more reagents in the above tests is regulated as an analyte specific reagent (ASR). These tests were developed and their performance characteristic determined by the Department of Pathology Laboratory at. They have not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. Special stains and/or immunohistochemical stains were performed with appropriately stained positive and negative controls.. INTERPRETATION: No PMS2 expression identified. The results of microsatellite instability testing will be issued as a separate report.
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diff --git a/output/text/82e28dc7-56fd-40f3-a721-b3eb4d6f1cb0.txt b/output/text/82e28dc7-56fd-40f3-a721-b3eb4d6f1cb0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0cd2333bcfb7ff91f1c651bffa3259db31433c2b
--- /dev/null
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@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+UUID:86750CA3-218B-4F37-BAB7-CCED5112C826 Print Date: TCGA-TS-A8AY-01A-PR Redacted Date Collected: Date Received.  years Sex: Female  Accession NI Physician: Copy to: Pathology Renort Surgical Collection Date/Time Received Date/Time Verified Date/Time Pathologist Accession Number Clinical Information year old female with mesothelioma; Left Thoracotomy, Bronchoscopy, PDT, Total Pleurectomy. Final Diagnosis 1. PREVIOUS INCISION: Skin and underlying soft tissue with changes consistent with previous site, no tumor seen. Calretinin stain contirms absence of mesothelioma. 2. RIB: Bone with trilinear bone marrow formation and tenosynovial type soft tissue and fibromuscular soft tissue, no tumor seen. 3. PERIAORTIC TISSUE: Fibrofatty soft tissue, no tumor seen. 4. LEVEL 5: Sections of lymph node, no tumor seen. CK5/6 stain confirms 5. PHRENIC NERVE: Fibrofatty soft tissue with prominent peripheral nerve tibers and signiticant acute inflammation. Fragment of soft tissue with presence of mesothelioma.. I0D 0 3 6. LEVEL 7: )Meosth len ur,epithiliesk, melicners Sections of lymph node, tumor present.. 9b82|3 Calretinin stain confirms Ste: VQeeoNoS 7. LEVEL 5/6: ( 38 i) Sections of lymph node, no tumor seen. CK5/6 stain contirms pJ 5/28/14 8. pOSTeRIOR InTErCOSTAL: Sections of lymph node, tumor present. Calretinin stain confirms 9. PLEURA: Mesothelioma, epithelioid type, closely associated but not invading lung tissue. Tumor comes close to skeletal muscle. No detinite muscle invasion identified (9C). Name: Page 1 of 4 MRN:
+
+--- Page 2 ---
+Print Date: Date Collected: Date Receivcd:- years Sex: Female Accession No C Physician: Copy to: Surgical Pathology Report Received Date/Time Verified Date/Time Pathologist Accession Number Collection Date/Time The tumor is positive for D2-40, calretinin, AE1-3, CK5/6 and WT1 and negative for CEA, MOC 31 TTF1 and CD15, contirming presence of mesothelioma.. 10. INTERLOBAR NODE: Sections of lymph node, no tumor seen.. CK5/6 stain contirms The case material was reviewed and the report verified by:. (Electronic signature) Verification Date: Note Mesothelioma Histologic Type Epithelioid mesothelioma. Margins Cannot be assessed. Lymph nodes Specify: Number examined: 5 levels. Number involved: 2 levels. Pathologic Staging (pT3 N1 Mx ) Staging discussed with surgeon Frozen Section Diagnosis FS1: Scar: No tumor seen at area of skin scar marked by surgeon. FS2: Periaortic Tissue: No tumor seen.. Dx Called To: Name: Page 2 of 4 MRN
+
+--- Page 3 ---
+Print Date: Date Collected: Date Received: years Sex: Female Accession No Age Physician: Copy to: Pathology Report Surgical Received Date/Time Verified Date/Time Pathologist Accession Number Collection Date/Time Gross Description The case is received in 10 containers, each labeled with the patient's name and medical record number.. Specimen #1 is received fresh for frozen section, designated as "Previous Incision" and consists of a 12.3 x 0.6 cm skin ellipse excised to a depth of 1.2 cm. The skin surtace is tan-white, wrinkled and slightly puckered. The specimen has been oriented by the surgeon with a stitch on an area of interest, which is submitted entirely tor frozen section as FS1 and the frozen section control is submitted in cassette 1A. Additional representative sections of the remainder of the specimen are submitted in cassette 1B. Specimen #2 is received in formalin, designated as "Rib" and consists of four cylindrical portions ot rib ranging trom 1.9 to. 5.7 cm in length and averaging 1.2 cm in diameter. There is a moderate amount of attached red-brown, rubbery muscie. Sectioning reveals tan-red, trabeculated cut surfaces. No discrete masses are grossly identified. Representative sections are submitted in cassette 2A following decalcification.. Specimen #3 is received fresh for frozen section, designated as "Peri-Aortic Tissue" and consists of a 0.3 x 0.3 x 0.2 cm. tan-white to tan-yellow, irregular soft tissue fragment, which is submitted entirely for trozen section as FS2 and the frozen section control is submitted in cassette 3A. Specimen #4 is received in formalin, designated as "Level 5" and consists of a 1.2 x 0.9 x 0.9 cm gray-black, indurated, nodular soft tissue fragment, which is bisected to reveal gray-black, dense cut surfaces. The specimen is submitted entirely in cassette 4A. Specimen #5 is received in formalin, designated as "Phrenic Nerve" and consists of two ragged and irregular to roughly cylindrical tan-grey, glistening soft tissue fragments measuring 2.9 and 15.7 cm in greatest dimension. The specimen is seriaily sectioned and submitted entirely in cassettes 5A and 5B.. Specimen #6 is received in formalin, designated as "Level 7" and consists of a 1.0 x 1.0 x 0.8 cm tan-gray, nodular soft tissue fragment, which is bisected to reveal tan-gray, dense cut surtaces. The specimen is submitted entirely in cassette 6A. Specimen #7 is received in formalin, designated as "Level 5/6" and consists of a 3.6 x 2.2 x 0.9 cm fragment of tan-yellow. adipose tissue, which incorporates four rubbery, possible lymph node ranging from 0.9 to 1.6 cm in greatest dimension. The specirnen is submitted entirely in cassettes 7A.. Specimen #8 is received in formalin, designated as "Posterior Intercostal" and consists of three tan-yellow, irregular soft tissue fragments ranging from 0.3 to 1.7 cm in greatest dimension. The larger fragment is bisected to reveal tan-gray,. Name Page 3 of 4 MRN!
+
+--- Page 4 ---
+Print Date Date Collected Date Received: years Sex: Female Accession No Physician: : Copy to: S u r g icaI Path0logy Report Collection Date/Time Reccived Date/Time Verified Date/T'ime Pathologist Aceession Number fragments are submitted In toto in casseite 8B.. Specimen #9 is received in formalin, designated as *Pleura" and consists of a 25.7 x 12.7 x 5.8 cm ragged and irregular. portion of tan-gray, tirm tissue which have a moderate amount ot attached red-brown, rubbery muscle, tan-white. tendinous tissue and tan-yellow, lobulated adipose tissue. Sectioning reveals tan-white to tan-pink, tirm, lobulated,. glistening thickened areas, measuring up to 8.7 x 6.5 x 1.7 cm. Representative sections are submitted in cassettes 9A through 9E. Specimen #10 is received in formalin, designated as "Interlobar Node" and consists of two tan-gray, rubbery, nodular to.  ragged and irregular soft tissue tragments measuring 1.9 and 3.7 cm in greatest dimension. The larger fragment. bisected and submitted entirely in cassettes 10A through 10E, respectively. Dictated by: Pathologist(s) M115/3 Nam Page + of 4 MRN:
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diff --git a/output/text/83182399-1ecc-4a28-8882-64cb290b72c8.txt b/output/text/83182399-1ecc-4a28-8882-64cb290b72c8.txt
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index 0000000000000000000000000000000000000000..a71c2aef2754378ad00a97dbcd3704a088fc5cc2
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+
+--- Page 1 ---
+TCGA-DZ-6132 Surgical Pathology REVISED REPORT Addendum/Procedure included). TISSUE DESCRIPTION: Tissue from right lateral kidney (3.5 x 3.4 x 1.6 cm) and. right kidney (2 specimens measuring 1.2 x 0.5 x 0.3 cm and 1.2 x 0.7 x 0.3 cm) DIAGNOSIS: Kidney, right, partial nephrectomy:  Grade 2 (of 4) renal. cell carcinoma, papillary cell type, forming a 2 x 1.8 x 1.8 cm. mass. The tumor is confined to the kidney. Coagulative tumor necrosis is absent. Sarcomatoid differentiation is absent..  The surgical margins are very focally positive..
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diff --git a/output/text/83238aac-eba4-4b44-b614-0717581e9d47.txt b/output/text/83238aac-eba4-4b44-b614-0717581e9d47.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b797a75c247507cf9c1a3821c50768be26afab01
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+
+--- Page 1 ---
+FINAL DIAGNOSIS: Part 1: Breast. Right, Segmental mastectomy - Invasive Ductal Carcinoma,nos type, poorLy Differentiated. B.  THe INVASiVE TUmOr MEASURES 2.0 Cm IN GREATESt DImeNSiON.nOTTINGhAm GRADE 3 (TUBULE FORmAtiON 3, NUClEAR PLeOmORphiSm 3, mITOtIC ACtivIty 3; tOTAL SCORE 9/9). C.  DUctAL CArcinOmA IN-SitU (DCIS), nUCLEAR GRADE 3, micROPaPILLARy AND PAPILLARy TYpeS WITH COMEDONECROSIS; CONSTITUTES 60% OF THE TOTAL TUMOR MASS AND IS PRESENT ADMIXED WITH AND AWAY FROM THE INVASIVE COMPONENT. D. LYMPH VASCULAR SPACE INVASION IS IDENTIFIED. E. RESECTION MARGINS ARE NEGATIVE fOR CARCINOMA, HOWEVER THE INVASIVE CARCINOMA EXTENDS TO 0.5 CM FROM THE ANTERIOR MARGIN.DUCTAL CARCINOMA IN-SITU EXTENDS TO <0.1 CM FROM THE LATeral mArgin AnD 0.2 Cm FrOm the AnTerIOR mARgin. F. SKIN IS NEGATIVE FOR TUMOR FIBrOcySTIC ChAnges WIth DuCtAl EPITheLiAl hypeRpLASIA, PReVIOUS bIOpSy SiTe ChAnGES. G. H. THe INVASIVe TumOR CeLLS ArE POsITIVe fOR eSTROgen AND PROgESTErOne ReCepTORS AND NEGATIVE fOR HER-2 (1+), AS PER PREVIOUS PATHOLOgY REPORT Part 2: breast, right, new deep margin, Segmental mastectomy - A.  NO CARCINOMA IDENTIFIED. B.  FiBROcySTiC ChAngES WIth DUctal EpiTHeLiAL hypERpLASiA,COLumnAR CeLl CHanGE. PART 3: Lymph NODE, RIgHT AXILLA, SEnTINeL #1, BIOPSY -- One Lymph nODe, nEgaTivE fOR metAStaTIC CARcInOmA (0/1). CASE SYNOPSIS: SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST 1cs-0-3 LATERALITy: PROCEDURE: Right Segmental Sihs, brust, Nos LOCATION: C50.9 3|13/11 h SIZE OF TUMOR: Not specified MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: Maximum dimension invasive component: 2 cm TUMOR TYPE (invasive component): No NOTTINGHAM SCORE: Ductal adenocarcinoma, NOS Nuclear grade: 3 Tubule formation: 3 Mitotic activity score: 3 Tota! Nottingham score: 9 ANGIOLYMPHATIC INVASION: Nottingham grade (1, 2, 3): 3 Yes DERMAL LYMPHATIC INVASION:S CALCIFICATION: No TumOr type, In SItu: Yes, malignant zones  Papillary  Micropapillary DCIS admixed and outside of invasive carcinoma component SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: Percent of tumor occupied by in situ component: 60 % No SURG MARGINS INVOLVED BY IN SITU COMPONENT: Distance of invasive tumor to closest margin: 5 mm No Distance of in situ disease to closest margin: 1 mm LYMPH NODES POSITIVE: LYMPH NODES EXAMINED: 0 METHOD(S) OF LYMPH NODE EXAMINATION: 1 SENTINEL NODE METASTASIS:  H/E stain UUID:1F35A542-2795-4B1F-A846-7097B442C2D9 TCgA-BH-A0hU-01A-PR  No Redacted ONLY KERATIN POSITIVE CELLS ARE PRESENT: SKIN INVOLVED (ULCERATION): No No NON-NEOPLASTiC BREAST TISSUE: FCD, Other: columnar cell change t Stage, pathologIC: N stage, pathologiC: pT1c pNO M STAgE, PAThOLOGIC: ESTROGEN RECEPTORS: pMX PROGESTERONE RECEPTORS: positive HER2/NEU:  positive zero or 1+ 3/131 #
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diff --git a/output/text/832d4f25-00d3-44a0-9c95-e6e4652868f0.txt b/output/text/832d4f25-00d3-44a0-9c95-e6e4652868f0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a6f73052c8cf07b0306ad79c0168711fc7a20327
--- /dev/null
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+
+--- Page 1 ---
+Procurement Date Laterality:Distal Path RepOrt:ESOPHAGUS TISSUE CHECKLIST Specimen type: Excision of tumor Tumor site: Esophagus Tumor size: 2 x 1.5 x 0.3 cm Histologic type: Squamous cell carcinoma, keratinizing Histologic grade: Moderately differentiated Tumor extent: Muscularis propria Lymph nodes: 0/7 positive for metastasis (Regional 0/7) Lymphatic invasion: Not specified Venous invasion: Not specified Margins: Uninvolved. JUID:DF3 TCGA-IG-A3QL-01A-PR Redacted Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None 10)-0 3 carc1nomq,Squamous q1l, XeoHni Zi^s 807i{3 Sik:esophagus,distu1third c15,5 L 28~1Z RD
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diff --git a/output/text/8340dd1d-2be6-4ebc-9bda-b4edd5d55345.txt b/output/text/8340dd1d-2be6-4ebc-9bda-b4edd5d55345.txt
new file mode 100644
index 0000000000000000000000000000000000000000..132eaa1f14b8d89d87458342935c3cf2e783ba5d
--- /dev/null
+++ b/output/text/8340dd1d-2be6-4ebc-9bda-b4edd5d55345.txt
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+
+--- Page 1 ---
+iCs-0:3 Sit Codi: suast, Nos Patient:- c50.9  Surgical Pathology: Additional Info Surg Path UUID:1E498731-FE74-493E-A330-477643800305 Redacted CLINICAL HISTORY: Left breast carcinoma. GROSS EXAMINATION: "Left breast tissue 3.5 x 2 x 2 AFi", received fresh. A previously A. incised unoriented 5.4 x 4.8 x 3.5 cm portion of yellow-white fibrofatty tissue. focally abutting the margin.  Representative tissue from the mass is frozen as. AFl, the remnant is submitted as Al. The majority of the remainder of the mass is submitted as A2-A5. B. "Left breast", received fresh. A 10360 gram 33 x 21 x 5. 5 cm mastectomy composed of a 29 x 16.3 cm ellipse of tan brown skin with underlying 28 x 21 x 5.5 cm of fibrofatty breast tissue and contiguous 9.0 x 5.8 x 2.4 cm of axillary contents. There is a central 5.5 cm areolar with a central everted 1.3 cm nipple. 6 cm lateral to the edge of the areolar is an 8 cm freshly sutured incision. The surgical margin is marked with blue ink and the specimen is sectioned to reveal an approximately 6 cm diameter cavity 0.6 cm subjacent to the previously described skin incision.  The cavity is within 1.4 cm of the deep margin and 3 cm from the closest soft tissue margin (inferior). The biopsy cavity is in the outer half of the specimen and has slightly indurated borders but no residual tumor grossly appreciated. The remainder of the breast parenchyma is composed primarily of yellow adipose tissue intermixed with focal dense pink fibroconnective tissue and no additional lesions noted. Block Summary: B1 - Nipple B2 - Edge of incision and underlying cavity. B3 -- Cavity in relationship to deep margin.. B4 - Representative of closest soft tissue margin (inferior). B5-6 Representative random cavity wall.. B7 - Random lower outer quadrant. B8 Random upper outer quadrant. B9 - Representative central parenchyma.. B10 - Lower inner quadrant. B11 -- Upper inner quadrant. B12 - One lymph node candidate, proximal. B13 - Four lymph node candidates, mid B14 - One bisected lymph node candidate, mid.. B15-17 Largest section of lymph node candidate, mid (4.7 x 2.4 x 0.9 cm. B18 - Two lymph node candidates, distal. INTRA OPERATIVE CONSULTATION: A. "Left breast tissue": AFl - invasive carcinoma present DIAGNOSIS: A. "LEFT BREAST TISSUE" (EXCISIONAL BIOPSY): INFILTRATING CARCINOMA PRESENT, HISTOLOGIC TYPE [DUCTAL.  N.S.A.B.P. NUCLEAR GRADE 3 OF 3. N.S.A.B.P. HISTOLOGIC GRADE 3 OF 3. GROSS TUMOR SIZE: 3.5 X 2 X 2 CM. SIZE OF INVASIVE COMPONENT: 3.5 X 2 X 2 CM. LYMPHATIC/VASCULAR INVASION: ABSENT. MULTIFOCAL TUMOR: ABSENT. 1 of2
+
+--- Page 2 ---
+IN-SITU CARCINOMA: PRESENT, OCCUPYING 5O% OF TUMOR (SEE COMMENT).) TYPE OF IN-SITU CARCINOMA: COMEDO, MICROPAPILLARY. SIZE OF IN-SITU CARCINOMA: APPROXIMATELY SIZE OF BIOPSY (5.4 CM). EXTENSIVE INTRADUCTAL COMPONENT: PRESENT. STATUS OF NON-NEOPLASTIC BREAST TISSUE: NOT APPLICABLE. SIZE OF BIOPSY: 5.4 X 4.8 X 3.5 CM. SURGICAL MARGIN STATUS: NOT EVALUATED. ESTROGEN/PROGESTERONE RECEPTOR AND CELL CYCLE ANALYSIS: PENDING. METHODOLOGY: IMMUNOHISTOCHEMISTRY, PARAFFIN BLOCK A4. RESULTS WILL BE ISSUED IN AN ADDENDUM. cOMMEnr: The tumor mass is a complex admixture of invasive and in-situ carcinoma.  The exact percentage of invasive carcinoma is difficult to determine with certainty, but is estimated at approximately 50%. B. "LEFT BREAST" (MODIFIED RADICAL MASTECTOMY): RESIDUAL INFILTRATING CARCINOMA ABSENT. RESIDUAL IN SITU CARCINOMA PRESENT. TYPE OF IN-SITU CARCINOMA MICROPAPILLARY. SIZE OF IN-SITU CARCINOMA: SEE COMMENT, EXTENSIVE. NIPPLE STATUS, FREE OF TUMOR. SKIN STATUS, FREE OF TUMOR. MUSCLE STATUS, NOT SAMPLED. STATUS OF NON-NEOPLASTIC BREAST TISSUE: FIBROCYSTIC CHANGES. SURGICAL MARGIN STATUS: NEGATIVE. LYMPH NODE STATUS: SEVEN LYMPH NODES, NO EVIDENCE OF MALIGNANCY (O/7).) COMMENT :  Random sections around the biopsy site show foci of residual in-situ. carcinoma. In addition, a random section in the central breast several cm away from the biopsy site is also positive for in-situ carcinoma, indicating a rather large area involved by'residual in-situ disease. The margins of resection are negative, however. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es). Electronically signed.. ADDENDUM 1: Tissue was sent to the image cytometry laboratory for assay of the estrogen and progesterone receptors. The estrogen receptor activity was judged to be negative with an estimated FmoL value of 0. The progesterone receptor activity was judged as negative with an estimated Fmol value of 0. Please refer to For a complete report.. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es). Electronically : 2 of 2
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diff --git a/output/text/8373df6b-3fb7-47cb-816a-de613d4d42db.txt b/output/text/8373df6b-3fb7-47cb-816a-de613d4d42db.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4859d1601d1d7bdbddf1d1c54769aba5a44e32fd
--- /dev/null
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+
+--- Page 1 ---
+Previous 05-44224M RT: SUPERIOR TURBINATE & ANTERIOR NASAL biopsies: SEPTUM. 04-43867M allograft renal biopsy 02-23164M ALLOGRAFT RENAL BIOPSY/is. 01-27641M TX KIDNEY BX/sr. (and more) DIAGNOSIS Right k.dney,recical nephrectomy: Chromophobe renal cell carcinoma. see svnontic renort. Kidney: Nephrectomy, partial or radical Synopsis MACROSCOPIC Spccimen Type: Right radical nephrectomy. Foce'y: Unik oel nass Temor Si Creatost dimansic: 3.0 r11. MICROSCOPIC riistio.icType:
+
+--- Page 2 ---
+Histologic Grade: G1: Nuclei round, uniform,approximately 10 microns;nucleoli inconspicuous or absent. EXTENT OF INVASION Primary Tumor: pT1a: Tumor 4 cm or less in greatest dimension, limited to the kidney. Regional Lymph Nodes: pNx: Cannot be assessed.. Lymph Nodes: None submitted. Distant metastasis: pMx: Cannot be assessed. Margins: Margins uninvolved by invasive carcinoma. Adrenal gland: Not present. Venous invasion: Absent. Comments: Colloidal iron stain shows focal granular cytoplasmic staining consistent with the. above diagnosis. The tumor arises in an end stage kidney. Clinical: Right ronal mass. Gross: The specimen is received fresh labeled with the patient's namie the medical record number and "right kidney",and consists of a laporascopic radical nephrectomy specimen. The kidney with attached perinephric fat weighs yian.ppn ia mkc ibanu o u licvCa a well circumscribed tan and brown nodule measuring 3.0 x 3.0 x 1.5 cm. The nodule abuts the renal capsule but no invasion into perinephric fat is noted. Small cysts are noted within the cortex. The remainder of the kidney is grossly unremarkable. The renal mass is sectioned and. a portion is taken for tissue bank. No adrenal gland is present. The specimen is represented. as follows: A=vascular margin, B=ureter margin, C-F=tumor in tumor relation to kidney and perinephric fat, F=cystic areas and cortex and samples of cortex and medulla, G=section of grossly unremarkable perinephric fat.
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diff --git a/output/text/837bab69-3ace-42be-b89d-20a42d04a03d.txt b/output/text/837bab69-3ace-42be-b89d-20a42d04a03d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ea2d01ef16fab0d2cff3a2b9d61e8f50e3e3ccdf
--- /dev/null
+++ b/output/text/837bab69-3ace-42be-b89d-20a42d04a03d.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Sample ID #: Diagnosis: Resectate of the colon (transverse colon) with inclusion of an ulcerated, moderately differentiated adenocarcinoma, of a maximum diameter of 6 cm, with infiltration of all layers of the wall, focatly into the pericolic fatty tissue. Tumor-free resection margins, tumor-free omental fat tissue and tumor-free lymph nodes.. Tumor classification: G2, pT3 N0 (0/32) L0 V0; R0 /cs-0-3 adncouci onn, nos 8140|3 Sih: FNunsvua cHor C18.y pw 3/9op UUID: 3A6D9A07-C421-4C87-AC68-2A6FC3BFD05D Redacted TCGA-AA-A00L-01A-PR
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diff --git a/output/text/83a341bf-b7a5-4c58-b180-997f7bd85cd9.txt b/output/text/83a341bf-b7a5-4c58-b180-997f7bd85cd9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..cec21fe6ec8a67f2e648f10e36262c778207e9c6
--- /dev/null
+++ b/output/text/83a341bf-b7a5-4c58-b180-997f7bd85cd9.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:5A8CDA1B-CD49-4177-9716-FD42DE663E29 TCGA-Lk-A406-01A-PR Redacted FINAL DIAGNOSIS: Summary Statement This extrapleural pneumonectomy specimen shows a blphasic mesothelioma diffusely nvoiving:the visceral and parietel pleural. The histoiogy Is predominantly epithelioid, with a mlnor spindle cell componant. The tumor invades.the.  diaphragm (non-transmural) and pericardlal fat isolated tumor nodules within the lung paronchyma, together with the.  angiolymphatic Invasion sean in the lung, are bast interpreted as matastatic disease: Almost all $submitted lymph nodes are invoived by tumor. Pertinent negatives include the absence of pleural plaques, ferruglnous/asbestos bodles. [pT3N1M1 AJCC 7t" Ed.J part 1: Lung, Left Lower lobe, wedge resection -. MESOTHELIOMA, INVOLVING THE VISCERAL PLEURA. PARt 2: PLeUrA, PARIeTaL, InCISIOnAl BIOpSy -- MESOTHELIOMA. Part 3:  Lymph node. Level 10, Biopsy - MESOTHELIOMA IN SUBCAPSULAR SINUSES part 4: Lymph node, Level 11, siopsy -  MESOTHELIOMA. Part 5:  Lymph node, near inferior pulmonary vein, biOpsy -- MESOTHELIOMA.. PART6: PericarDiaL Fat, Biopsy -- MESOTHELIOMA, FORMING MULTIPLE SMALL FOCI IN ADIPOSE TISSUE. Part 7:  Diaphragm fat, biopsy - MESOTheLiOmA, FORming ONE SMALL (0.1 CM) IMpLANt IN ADIPOSE TISSUE. Part 8:  Lung, Left, extrapleural pneumonectomy -- BIphaSiC mesotheLiOmA, PredoMinanTLy epITheLiOID wITH minor SpinDle CeLl cOmponent, A Circumferentially and diffusely involving the visceral and parietal pleura.  Surgical margins Are positive for Tumor at the LAtera! Parietal And inFeriOr PARIETAL PLEURAL MARGINS!! b. i' bronchovascuLar mArgins'are negative for tumOR:: yt3 ANGIOLYMPHATIC INVASION I$PRESENT. d.: PATHOLOGIC STAGE: pT3N1M"(AJCC 7" Ed.). .B.. metASTATIC mesOTHeLiOmA ForminG'ISOLateD PULmonAry nODULes Five Ni Lymph nODes wiTh metastaTIc mesoTHeLiOma (5/6).  NO feRruGInous/asBestOs boDies iDentiFied On iron stAIns Of TwO sEcTIoNs.  NO PLEURAL PLAQUE IDENTIFIED. F : nOn-NeopLastic Lung showing BronchIectasis anD Bronchiolectasis wIThout interstITiAl. FIBROSIS. Part 9: , DIaphrAGm, RESecTION --  MESOTHeLiOmA, INFIL TRATIng SKELetAl mUSCle (nOn-TranSMURAL). : COMMENT: < Immunohistochemidal staining shows tumor cells to be positive for AE1/2, Cam3.2 and focally positive for calratinin, CK5/6, WT1, D2-40, BerEp4 and CD15. Tumor cells are negaive for TAG72, MOC31, monoclonal CEA, PAx-8, Inhibin, and TTF-1. Mugin stains(mucicarmine, PAs0) are.negative. Immunoreactivity for BerEp4 and CD15 is less extensive than that for the othar mosotheiial markers. The mesothelial markere hlghlight predominantly the epithelloid component, while the spindle cell compgnent ruostyl stains with cytokeratin antibodies. A pancytokeratin aiso stain highilghts the tumar cells in the levei 10 lymphi nods (Part 3): A NC CASE SYNOPSIS: 1cs-0-3 SYNOPTIC DATA! PRIMARY. MESOTHELIOMA SPECIMEN: F JMA.  Pleura Mesvthulicma biphasiC,Nos 9053f3 Other: Lung PROCEDURE: Extrapleyral pneumonectomy Jeura, Nus L38.4 SPECIMEN INTEGRITY: Disrupted  SPEcImEN LATERANL Left, TUMOR SITE:S Visceral,pleura Diaphragm Pericardu Othor: Lyng TUMOR FOCALITY: HISTOLOGIC TYPE: Biphastc.mesothelloma TUMOR EXTENSION Confluent visceral pleural tumor (including fissure) Int but not through diaphragm Lurig parenchyma Diffause or multiple focl invading soft tissue of'chest wal!. Into but not through pericardium MARGINS: Margin(s) involved by mesothelioma Margin(s): Outer soft tissue margin, multifoca) TREATMENT EFFECT: Notapplicable PATHOLOGIC STAGING (pTNM)  pT3 pN1 Number examined: 9 Number involved: 8 pM1 Site(s): Lung ADDITIONAL PATHOLOGIG FINDINGS: :NOne Identified ANCILLARY STUOIES: Imrpunohistgchemical slain(s Histochemical stain(s)
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diff --git a/output/text/83c07263-c0b6-4cdc-be53-efafcb49f739.txt b/output/text/83c07263-c0b6-4cdc-be53-efafcb49f739.txt
new file mode 100644
index 0000000000000000000000000000000000000000..63db9a3ff575f476ce64242b8e9c4e3405bcd76a
--- /dev/null
+++ b/output/text/83c07263-c0b6-4cdc-be53-efafcb49f739.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+1Cs-0 -3 UUID: 803922CD-3D37-47DC-88DC-EF8F4779685A0 Redacted TCGA-E2-A570-01A-PR CuvUionn,mfitrsHNj iucf,10s f5ovf3 Sih, huwt, NUs 0 50.9 lw A. SENTINEL NODE #1 RIGHT AXILLA SPECIMEN(S): B. SENTINEL NODE #2 RIGHT AXILLA C. RIGHT BREAST D. SENTINEL LYMPH NODE #3 RIGHT AXILLA E. RIGHT BREAST SKIN CLINICAL HISTORY: Right breast lower inner quadrant @ 4:00 position -- 2.3cm invasive ductal carcinoma.. PRE-OPERATIVE DIAGNOSIS: None Given INTRAOPERATIVE CONSULTATION: TPA: sentinel node #1 right axilla- Negative for carcinoma. Diagnosis called to Dr. at by Dr. TPB1-TPB2: sentinel node #2 right axilla- Negative for carcinoma. Diagnosis called to Dr. at by Dr. DIAGNOSIS: A. LYMPH NODE, SENTINEL #1, RIGHT AXILLA, EXCISION: - METASTATIC CARCINOMA TO ONE OF ONE LYMPH NODE (1/1), MEASURING 0.05-CM (MICROMETASTASES), WITHOUT EXTRANODAL EXTENSION, SEE NOTE. B. LYMPH NODES, SENTINEL #2, RIGHT AXILLA, EXCISION: - TWO LYMPH NODES, NEGATIVE FOR METASTASES (0/2) C. BREAST, RIGHT, MASTECTOMY: - INVASIVE DUCTAL CARCINOMA, SBR GRADE 1, MEASURING 1.5 CM - INTERMEDIATE NUCLEAR GRADE, DUCTAL CARCINOMA IN SITU, SOLID, CRIBRIFORM AND MICROPAPILLARY TYPES, WITH MICROCALCIFICATIONS AND CENTRAL NECROSIS - DCIS WITHIN 1 MM OF ANTERIOR INFERIOR SURGICAL MARGIN - SURGICAL RESECTION MARGINS NEGATIVE FOR INVASIVE TUMOR - LOBULAR CARCINOMA IN SITU - BIOPSY SITE CHANGES WITH FIBROSIS, GRANULATION TISSUE. AND FAT NECROSIS - SEE SYNOPTIC REPORT. D. LYMPH NODES, SENTINEL #3, RIGHT AXILLA, EXCISION: - FOUR LYMPH NODES, NEGATIVE FOR METASTASES (O/4).
+
+--- Page 2 ---
+E. SKIN, LEFT BREAST, RECONSTRUCTION: - SKIN TISSUE, NO TUMOR SEEN. NOTE: The touch preparation of sentinel lymph node #1 is reviewed, no tumor cells identified. Therefore, the false negativity is due to sampling variability. SYNOPTIC REPORT - BREAST Specimen Type:  Mastectomy Needle Localization: No Laterality: Right Invasive Tumor: Present Multifocality: No WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Tumor size: 1.5cm Tumor Site:  Lower inner quadrant Tubular Score: 2 Nuclear Grade: 1 Mitotic Score: 1 Modified Scarff Bloom Richardson Grade: Necrosis: Absent Vascular/Lymphatic Invasion: None identified Lobular neoplasia: LCIS Lymph nodes: Sentinel lymph node Lymph node status:  Positive 1/ 7 Micrometastases: Yes DCIS present Margins uninvolved by DCis Within 1mm of anterior inferior margin DCIS Quantity: Estimate 30% DCIS Type: Solid Cribriform Micropapillary DCIS Location: Associated with invasive tumor Nuclear grade: Intermediate Necrosis: Present Location of CA++: DCIS ER/PR/HER2 Results ER: Positive PR: Positive HER2: Negative by FISH Performed on Case: Pathological staging (pTN): pT 1c N 1mi  Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition
+
+--- Page 3 ---
+GROSS DESCRIPTION: A. SENTINEL NODE #1 RIGHT AXILLA Received fresh for frozen section labeled with the patient's identification and 'sentinel. node #1 right axilla' is a tan pink lymph node 0.7 x 0.7 x 0.5cm. The specimen is serially. sectioned and a touch prep is taken. Toto A1. B. SENTINEL NODE #2 RIGHT AXILLA Received fresh for frozen section labeled with the patient's identification and 'sentinel. node #2 right axilla' are two tan pink lymph nodes 2 x 1.2 x 0.7cm and 0.6 x 0.3 x 0.3cm. The specimens are serially sectioned and two touch preps are taken.. B1: one lymph node. B2: one lymph node C. RIGHT BREAST Received fresh labeled with the patient's identification and "right breast' is a 160g, 15 x 14 x 3.5cm oriented (stitch in axilla) simple mastectomy with attached 8 x 3cm tan brown. skin ellipse and O.9cm everted nipple. Ink code: anterior-superior: blue, anterior-inferior: orange, posterior-black. The specimen is serially sectioned from medial to lateral into 9 slices with nipple in slice 3, revealing a 2.1 x 1.6 x 1.5cm tan white firm well. circumscribed mass, 0.7cm from the closest anterior-inferior margin and 1.2cm from the deep margin in the LIQ of slices 4-5. A biopsy clip is identified in the LIQ of slice 5. A portion of the specimen is submitted for tissue procurement. Representatively submitted: C1: nipple slice 3 C2: UOQ slice 1 C3: LOQ slice 1 C4: UOQ slice 2 C5: LOQ slice 2 C6: UC slice 3 C7: LC slice 3 C8: UIQ slice 4 C9-C10: mass LIQ with anterior-inferior margin slice 4 C11: deep margin and skin LIQ slice 4. C12: mass LIQ with anterior-inferior margin with clip ID slice 5 C13: UIQ slice 5 C14: LIQ slice 6 D. SENTINEL LYMPH NODE #3 RIGHT AXILLA Received fresh labeled with the patient's identification and 'sentinel node #3 right axilla are four tan pink lymph nodes ranging from 0.9 x 0.6 x 0.3cm to 0.5 x 0.5 x 0.5cm. Toto D1. E. LEFT BREAST SKIN Received in formalin labeled with the patient identification and designated "left breast. skin" is a tan-white in fragment, 22 x 1.4 x 0.6 cm. Serial sectioning reveals no discrete lesions. Representatively submitted in E1-E2.
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diff --git a/output/text/84363750-0dd0-45fc-b178-78f4d021f43e.txt b/output/text/84363750-0dd0-45fc-b178-78f4d021f43e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..282826bc12c6741d671948bb50defa3cf50044e0
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+
+--- Page 1 ---
+TCGA-E9-A5FL-01A-PR Redacted Gross Description: There is a breast with cystic tumor up to 5.5x4 cm in size. In the fatty tissue there are dense hyperemic lymph nodes with lipomatosis.. Microscopic Description: Metaplastic squamous cell carcinoma of the breast. Ten examined lymph nodes demonstrated sinus histiocytosis.. IHC-stainings: ER/PR/ Her-2/neu - negative reactions. Ki-67 - 30% Diagnosis Details: Tumor Features: Indeterminate, Tumor Extent: T3 tumor size more than 5 cm, Venous Invasion: Absent, Margins: Absent, Treatment Effect: Comments: IcD-6-3 Formatted Path Reports: BREAST TISSUE CHECKLIST lercinomo-,metepbstc NOS 8s75/3 Specimen type: Radical mastectomy Breast, NsS C50.9 Site. Specimen size: Not specified W/o|i3 Tumor site: Breast Tumor size: 4 x 0 x 5.5 cm Grossly evident lesion: Yes Histologic type: Metaplastic carcinoma Histologic grade: Not specified Tumor extent: Not specified Lymph nodes: 0/10 positive for metastasis (Axillary 0/10) Extracapsular invasion of the lymph nodes: Not specified. Margins: Uninvolved Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified
+
+--- Page 2 ---
+Total Nottingham Score: Score cannot be determined. Evidence of neo-adjuvant treatment: Not specified. Additional pathologic findings: IHC-stainings: ER/PR/ Her-2/neu - negative reactions. Ki-67 - 30%. Comments: Right
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diff --git a/output/text/8436604a-f294-48bb-90e4-e3caafcefc90.txt b/output/text/8436604a-f294-48bb-90e4-e3caafcefc90.txt
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index 0000000000000000000000000000000000000000..05c1a276e54ee39fa443d55854fad312f406199f
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+
+--- Page 1 ---
+TCGA-B9-5155 Surgical Pathology Report Diagnosis: Kidney, right, nephrectomy Histologic tumor type/subtype: Clear cell papillary renal cell carcinoma of end stage kidney (renal tumor #2 and a tiny tumor in specimen A13 away from the main tumor mass), papillary adenoma (renal tumor #1), and numerous tiny papillary adenomas. Histologic grade (if applicable): Tumor size (greatest dimension): The clear cell papillary renal cell carcinomas are 2.0 and 0.15 cm, the larger papillary adenoma is 2.0 cm, and the tiny papillary adenomas are 1-2 mm. Extent of tumor invasion: Capsular invasion/perirenal adipose tissue: The larger clear cell papillary renal cell carcinoma focally extends into perirenal adipose tissue (block A6) Gerota' s fascia: not identified Renal vein: not identified Ureter: not identified Venous (large vessel): not identified Lymphatic (small vessel): not identified Histologic assessment of surgical margins: Perirenal adipose tissue: free of tumor Gerota' s fascia: free of tumor Renal vein: free of tumor Renal artery: free of tumor Ureter: free of tumor Adrenal gland: not present in specimen Lymph nodes: none present in specimen Other significant findings: The background kidney shows end stage renal disease, with numerous senescent glomeruli, atrophy of tubules, thinning of renal cortex, and arterionephrosclerosis. AJCC Staging: pT3 pNx This staging information is based on information available at the time of this report, and is subject to change pending clinical review and additional information. Clinical History: with renal lesion. Gross Description: Received is one appropriately labeled container, additionally labeled "right kidney". Specimen fixation: Formalin Type of specimen: Radical nephrectomy
+
+--- Page 2 ---
+Side of specimen: Right. Size and weight of specimen: Weight: 850 grams; Dimensions: 23.0 x 11.0 x 8.0 cm; Kidney dimensions: 11.0 x 8.0 x 7.0 cm. No adrenal gland is identified. Orientation: The perinephric adipose tissue is inked green. Presence/absence of adrenal gland: Not grossly identified Tumor description/site: There is a tan/pink well-circumscribed nodule in the inferior pole which distorts the. capsule. This nodule exhibits a central area of hemorrhage and necrosis. 1.5 cm superior to this nodule is a 0.4 cm in greatest dimension satellite lesion which is well-circumscribed tan/pink. Also present in the superior pole 6.5 cm parallel to the initial nodule is a well-circumscribed golden yellow/orange hemorrhagic soft nodule, which also. distorts the capsule. Both of the nodules are present in the renal cortex.. Tumor size: The first tumor is 2.0 x 2.0 x1.5 cm; the second nodule parallel to it is 2.0 x 1.5 x 1.5 cm.. Presence/absence of multicentricity: Present. One location is 2.5 cm superior to the first nodule, 0.3 cm in greatest dimension. Confinement/non-confinement to the kidney: The nodules appear directly below the renal capsule, without definite extension through capsule. Extent of invasion:. Perirenal adipose tissue: Tumor does not grossly involve Gerota' s fascia: Tumor grossly involves Renal vein: Tumor does not grossly involve Ureter: Tumor does not grossly involve Other organs: Tumor does not grossly involve Surgical margins:. Perirenal adipose tissue: Negative, appears to grossly abut Renal vein: Negative. First nodule is 3.0 cm from the renal vein, second is 4.0 cm from renal vein margin. Renal artery: Negative. First nodule is 3.5 cm from the renal artery, second is 5.0 cm from renal artery. Ureter: Negative. First nodule is 3.7 cm from the ureter, second is 5.5 cm from the ureter. Description of kidney away from tumor: The remainder of the kidney parenchyma is atrophic and diffusely cystic with a cortex and medulla that cannot be distinguished. There are multiple tiny white nodules in the renal cortex, ranging from 1-2 mm, away from the dominant tumor nodules.. Lymph nodes (hilar): A 2.3 cm in greatest dimension lymph node candidate is identified. Other significant findings: The renal pelvis is markedly fatty.. Also received in the container is a detached portion of adipose tissue.. Tissue submitted for special investigations: Tumor and normal submitted to tissue procurement. Digital photograph taken: No Block Summary: A1 - Ureter, vein and artery margins A2 - First tumor with adjacent normal parenchyma
+
+--- Page 3 ---
+A3 - First tumor expanding the capsule. A4 - First tumor and closest ink. A5 - Second tumor with nornal parenchyma A6 - Second tumor with expanding capsule A7 - Second tumor and closest ink. A8 - Normal kidney parenchyma. A9 - Representative section of cystic area in kidney A10 - Hilar lymph node candidate and representative sections of the additional adipose tissue A11-A14 - Additional sections of renal parenchyma, with tiny cortical white nodules sampled Light Microscopy: Light microscopic examination is performed
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diff --git a/output/text/8491561d-4282-4c80-b2b7-482a6fff7a58.txt b/output/text/8491561d-4282-4c80-b2b7-482a6fff7a58.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d9b37575bb89e32ed09ecf7a005da3272e78485b
--- /dev/null
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+
+--- Page 1 ---
+PATHOLOGIC DIAGNOSIS: A. SPECIMEN DESIGNATED "RIGHT KIDNEY": RENAL CELL CARCINOMA, clear cell type (5.5 cm), Fuhrman nuclear grade II/IV. No capsular or perirenal soft tissue invasion present. The tumor invades the renal vein and is present at the renal vein margin. The renal artery, ureter, and Gerota's fascia resection margins are negative for tumor.. AJCC Classification (6th Edition): T3b Nx MX. Adrenal gland with no significant pathologic change. The non-neoplastic kidney wili be evaluated by Renal Pathology, and the findings will be reported in an addendum. CLINICAL DATA: History: with renal tumor. Operation: Right radical nephrectomy.. Operative Findings:  Not given. clinical Diagnosis: Right renal cancer. TISSUE SUBMITTED: A/1. Right kidney GROSS DESCRIPTION: The specimen is received in formalin, labeled with the patient's name and unit. number, and consists of a 1347-gram, 28.0 x 13.0 x 8.0 cm riqht nephrectomy specimen, partially surfaced by freely-mobile, smooth, tan/white Gerota's fascia (2o.5 x 14.0 cm, inked black), and with abundant attached perirenal adipose tissue (soft tissue margin inked blue).  The right kidney (13.5 x 6.5 x 5.9 cm) demonstrates a well-circumscribed, seemingly encapsulated, 5.5 x 4.5 x. 4.0 cm, yellow/orange, lobulated, multifocally hemorrhagic, solid tumor in the. upper pole, which abuts and expands but does not grossly appear to invade the. renal capsule. The tumor grossly invades multiple branches of the renal vein, including the main vessel, and is present at the renal vein margin. The closest Gerota's fascia is within 0.3 cm; the closest blue-inked soft tissue margin is within 2.5 cm. There are no grossly apparent satellite nodules noted upon sectioning the remaining renal parenchyma.  The corticomedullary junction. is distinct. The renal pelvis is lined by hemorrhagic, otherwise unremarkable urothelium. 0.3 cm of grossly involved renal vein (diameter 1.8 cm) extends from the renal hilum along with 0.3 cm of renal artery (diameter of o.3 cm). and 3 cm of right ureter (diameter is 0.6 cm).  Separately received with the. specimen is a questionably complete, 5.9 x 1.9 x 0.4 cm, disrupted adrenal gland.  In addition, there are multiple fragments of smooth, nodular tumor and clotted blood received in the specimen container (aggregating 6.5 x 6.5 x 3.0  Representative tumor has been submitted to the tissue bank. Representative tumor is submitted for cytogenetics studies and held for possible electron microscopy studies.  Representative normal cortex has been submitted to the tissue bank, EM, and IF. Representative normal medulla has. been submitted to the tissue bank. The specimen has been photographed. Micro Al: Vascular, ureteral margins (excepting renal vein), multi frags Micro A2: Tumor at renal vein margin (inked blue), en face, 1 frag, Micro A3: Tumor and renal capsule, nearest blue inked soft tissue margin, frags, Micro A4:  Tumor and nearest Gerota's fascia (inked black), 1 fraq,
+
+--- Page 2 ---
+ADDENDUM TO REPORT RENAL PATHOLOGY EVALUATION OF KIDNEY PARENCHYMA: RIGHT KIDNEY, NEPHRECTOMY: ARTERIAL AND ARTERIOLAR SCLEROSIS, MODERATE TO SEVERE, VASOCONSTRICTION, AND JUXTAGLOMERULAR CELL HYPERPLASIA (See NOTE) MILD TO MODERATE CHRONIC CHANGES OF THE KIDNEY PARENCHYMA, INCLUDING: -FOCAL GLOBAL GLOMERULOSCLEROSIS, MILD, PREDOMINANTLY SUBCAPSULAR, AND MOST LIKELY SECONDARY TO VASCULAR DISEASE (3.1% OF GLOMERULI) ; TUBULAR ATROPHY AND INTERSTITIAL FIBROSIS, MODERATE (20% OF) PARENCHYMA). WITH SUBCAPSULAR FIBROSIS NOTE : Chronic changes: Moderately advanced chronic changes are present, including global glomerulosclerosis affecting 3.1t of glomeruli, tubular atrophy and interstitial fibrosis affecting 2os of the cortical parenchyma, and a mild degree of vascular scarring, including subcapsular fibrosis. Because these. changes are a result of functional adaptations to nephron loss from any glomerular, tubular, interstitial, vascular, or mass-replacing process, similar degree of chronic damage would be expected in the contralateral kidney. In this case the vascular changes are significant, with arterial and arteriolar. sclerosis, moderate to severe.. The kidney parenchyma has been reviewed by MICROSCOPIC DESCRIPTION:S Light Microscopy: Sections of formalin-fixed, paraffin-embedded tissue (block A7) were evaluated using H&E, PAS,. silver methenamine, and AFOG (trichrome) stains.. The sample consists of cortex and medulla. There are 224 glomeruli present, of. which 7 (3.1t) are globally sclerosed, and 1 show segmentai glomerulosclerosis. The remaining glomeruli show mild expansion of the mesangial areas. There are no discernible craters or double contours of the glomerular capillary wall basement membranes. There is juxtaglomerular cell hyperplasia.' Several distal. tubules contain PAs-positive hyaline casts. The interstitium contains a mild mononuclear cell inflammatory infiltrate in areas of tubular atrophy. Approximately 20t of the cortical parenchyma shows tubular atrophy and interstitial fibrosis with subcapsular fibrosis mild. Arteries and arterioles exhibit moderate to severe degree of sclerosis..
+
+--- Page 3 ---
+KARYOTYPE : 43,xY,-3,+5,-6,-8,-9,+12,-14,der(16)t(8;16) (q1?1;q1?2) [8]/46,XY[2] METAPHASES COUNTED: 10 ANALYZED: 5  SCORED: 5 BANDING : INTERPRETATION: Eight of. 10 metaphases contained clonal aberrations described above including renal cell carcinoma, clear cell type. COMMENTS : Mosaicism and small chromosome anomalies may not be detectable using the standard methods employed.  Chromosome analysis was performed at a level of 400 bands or greater. INDICATION FOR TEST:
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diff --git a/output/text/84927e55-632b-48a4-9ea1-643fa054187f.txt b/output/text/84927e55-632b-48a4-9ea1-643fa054187f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..28db940735eb7a5d1a5771ec14092dd5b92b60a3
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+
+--- Page 1 ---
+UUID: A8F63D86-37DF-472E -AF29-F8734EAB7E5C Reda cted CGA-D8-A3Z6-01A-PR Department of Cancer Pathology Patient: XXX : xxx Age: Gender Examination result Unit in charge: Physician in charge:. Clinical diagnosis (suspicion): Cancer of the left breast Date of admission: (urgency: Standard) Material: 1) Material: left breast and axillary tissue. Method of collection: Total organ resection Histopathological diagnosis:. Examination performed on: Invasive, multifocal labular carcinoma of the left breast. Cancer metastases to axillary lymph nodes (19/22) (NHG2, pT3, pN3a) Macroscopic description: Left breast, sized 27.4 x 15.4 x 6.8 cm, removed without axillary tissues sized 10x 11x5 cm and with a skin flap of 20.2 x 8.2 cm. Tumour sized 6.2 x 3.6 x 4.8 cm found in the central part, placed 1.4 cm from the upper boundary, 0.8 cm from the base and 0.6 cm from the skin. State after removal of a tumour fragment. Lymph nodes of 3.3 cm in length Microscopic description: Invasive multifocal lobular carcinoma (histocytoid type) - NHG2 (3 + 3 + 1/5 mitoses/ 10 HPF - vision area 0,55 mm). Ductal carcinoma in situ (solid type, with high nuclear atypia and comedo necrosis, 10% of the tumour). The nipple without pathological lesions.. Glandular tissue showing fibrocytoid lesions adenosis. Axillary lymph nodes: Cancer metastases to axillary lymph nodes (19/22). Signs of perilymphatic invasion. Assistant: Pathologist Edited b CONTACT YOUR DOCTOR WITH THIS REPORT! 1cD-o-3 carcinma,1nF1+a+nq,l0buk4r,NOS 85z0f3 Sik: biegst,N0s. C 50,q LKe1Z kD
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diff --git a/output/text/84c73ac2-7e69-4397-bdc3-7e0d2edba5a7.txt b/output/text/84c73ac2-7e69-4397-bdc3-7e0d2edba5a7.txt
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index 0000000000000000000000000000000000000000..81825e6bae65a5bdb1cfb00a890b56e3352f3996
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+UUID:7A18CAC6-457B-4CB1-9998-14772FF66370 IcDo-3 TCGA-G7-A8LD-01A-PR Redacted 8at3 Sit $sney nOS C649 SPECIMENS: A. LEFT KIDNEY M u[z4I 3 B. LEFT PERIAORTIC LYMPH NODES SPECIMEN(S): A. LEFT KIDNEY B. LEFT PERIAORTIC LYMPH NODES DIAGNOSIS: A. KIDNEY, LEFT, NEPHRECTOMY: - PAPILLARY RENAL CELL CARCINOMA (7.5 X 6.3 X 6.1 CM,), TYPE II, FUHRMAN NUCLEAR GRADE 3 - TUMOR EXTENDS INTO PERINEPHRIC AND RENAL SINUS ADIPOSE TISSUE - LYMPHOVASCULAR INVASION IDENTIFIED - SURGICAL MARGINS NEGATIVE FOR CARCINOMA - SEE SYNOPTIC REPORT B. LYMPH NODE, PERIAORTIC, LEFT, EXCISION: - NINE OUT OF ELEVEN LYMPH NODES POSITIVE FOR METASTATIC CARCINOMA (9/11) SYNOPTIC REPORT - KIDNEY (PARTIAL OR RADICAL)S Specimens Involved Specimens: A: LEFT KIDNEY B: LEFT PERIAORTIC LYMPH NODES Specimen Type: Radical nephrectomy With adrenal gland Laterality:Left Tumor Site: Lower pole Focality:  Unifocal Tumor Size (largest tumor if multiple): Greatest dimension:. 7.5cm Additional dimensions: 6.3cm x 6.1cm Macroscopic Extent of Tumor: Tumor extension into perinephric tissues WHO CLASSIFICATION Papillary renal cell carcinoma 8260/3 Histologic Grade (Fuhrman Nuclear Grade): G3: Nuclei very irregular, approximately 20 u; nucleoli large and prominent. Invasion of Vascular/Lymphatic: Present Perinephric Tissue Invasion: Present Margins:  Margins uninvolved by invasive carcinoma Adrenal Gland:  Uninvolved by tumor Regional Lymph Nodes: Positive 9 /11 Additional Findings: None identified. Pathological Staging (pTNM): pT 3a N 1 M X Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition. GROSS DESCRIPTION: A. LEFT KIDNEY Received fresh labeled with the patient's identification and "left kidney" is a 1036 g kidney with attached perinephric fat, 24 x 9 x 8.3 cm. The adrenal gland is golden-orange and measures1.4 x 0.5 x 0.4 cm. The ureter is 9.5 x 0.3 cm; it is probe patent and contains a green Teflon catheter. The specimen is inked black; it is bisected. The kidney is 19 x 7.8 x 5.5 cm. The renal pelvis is dilated and protruding from the calyx into the pelvis is a friable brown-tan hemorrhagic mass. The lower pole contains a friable,. papillary, hemorrhagic golden tan necrotic mass, 7.5 x 6.3 x 6.1 cm. The mass grossly extends into the renal pelvis and pushes on the capsule. The renal fat surrounding the mass is edematous. The soft tissue surrounding the dilated renal pelvis has a white-yellow discoloration. The remainder of the parenchyma is unremarkable. Photograph is taken and tissue is procured; representatively submitted:
+
+--- Page 2 ---
+A1: shave of ureter margin A2: shave of vasculature margins A3: adrenal gland A4-A6: mass and relationship to renal sinus and pelvis. A7: hemorrhagic and necrotic a portion of the mass A8-A10: mass in relationship to capsule and perinephric fat. A11-A12: mass and edematous fat A13: area of discoloration surrounding renal pelvis. A14: normal appearing parenchyma B. LEFT PERIAORTIC LYMPH NODES Received without fixative in a container labeled with the patient's identification and designated "periaortic lymph nodes" are multiple fragments of fibroadipose tissue measuring 8.5 x 7.9 x 1.8 cm in aggregate. Sectioning shows multiple possible lymph nodes ranging from 0.9 x 0.5 x 0.4 up to 3.2 x 1.2 x 1.2 cm. Cassettes are submitted as follows: B1: 3 possible lymph nodes B2: 2 possible lymph nodes 83: One lymph node B4-B5: One lymph node B6: Representative sections, one lymph node B7: Representative sections, one lymph node B8:Representative sections one lymph node B9-B10: One lymph node CLINICAL HISTORY: None Given PRE-OPERATIVE DIAGNOSIS: Left kidney mass Gross Dictation:., Pathologist, Microscopic/Diagnostic Dictation: Final Review: Pathologist, Final Review.., Pathologis Final Review: Pathologist, Final:., Pathologist,
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diff --git a/output/text/84de234a-1ea9-4e81-a367-56d6d7ff79f6.txt b/output/text/84de234a-1ea9-4e81-a367-56d6d7ff79f6.txt
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+P.13/33 INAL DIAGNOSIS: Part 1: Breast. RIght. SEgmental. mAstectomy - A.  (Nfiltrating Quctal Carcinoma, nos type, moderately Differentiated. B. The tumor measures 2.3 cm (gross measurement), nottingham score 6/9 (tubuLes 2. nuclear grade 2, mitoses 2). overall grade 213. C. DUCTAL CARCINOMA IN-SITU (DCIS), CRIBRIFORM TYPE WITH ASSOCIATED COMEDO NECROSIS. nUCLEAR GRADE 2. COMPRISiNG 5% OF TOTaL TUMOR VOLUME AND iS PRESENT IN ASSOCIATiON WITH INVASIVE CARCINOMA. D.  NO DEFINITIVE LYMPHOVASCULAR INVASION iS SEEN.  MArGins: The invasive CArcinOmA exTends tO The SUperiOr margin, RemAIndeR OF mArGINS E. ARE FREE. F. ATypical DUctal hyperpLAsia, fLAt EpItheLiAl Atypia. FiBrOCysTIc Changes wiTH ASsOciated CaLcIfICatIONs. DUctal EpitheLial hyperpLASiA, FIBrOADenomatOID noDuLe AnD Previous biopsy site Changes. G.  ER-pOsITIVe, pr-pOsiTivE, hER 2Ineu-nEgaTIve (inc SCORe 0), CrOSS REfer PARt 2: #1 SEnTinel Lymph nODE, RIght AXiLLA, biOpSy - A. One lymph node positive for micro metastatic Carcinoma (1/1).  THe mETASTATIC fOCUs mEASUREs 1mm (ON gLASS SLIDe), NO eXtrA CAPSULAR eXTenSION IS IDENTIFIED. 1cs-0-3 Part 3: #2 Sentinel Lymph nODe. Right AxiLla, biopsy - One bEnIgn Lymph nOde, nO TUmOR SEen (0/1). Carcinoms,nip/trutrny outl nr3 8500/3 Sih: bunot, Nos C50.9 3f3/11 h part 4: #1 non-senTinel Lymph node. Right AxiLLA, BiOpsy - One benign lymph node, no tumor seen (0/1). Case s7norsis. SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST LATEraLiTy: procedure: Right LOcATION:  Segmental Not specified SIZE OF TUMOR: MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:  Maximum dimension invasive component: 2.3 cm TUMOR TYPE (Invasive component): No NOTTINGHAM SCORE: Ductal adenocarcinoma, NOS Nuclear grade: 2 Tubule formation: 2 Mitotic activity score: 2 Total Nottingham score: 6 UUID:D644B589-A6ED-4DCC-97D4-751E22AE3A7D ANGIOLYMPHATIC INVASION: Nottingham grade (1. 2, 3): 2 TCGA-BH-A0DQ-01A-PR Redacted DERMAL LYMPHATIC INVASION: No CALCIFICATION: Not applicable Tumor type, in situ: No Cribriform Comedo DCIS admixad with invasive carcinoma SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: Percant of tumor occupied by in situ component: 5 %. Yes, focal SURG MARGINS INVOLVED BY IN SITU COMPONENT: LYMPH NODES POSITiVE: No Lymph nOdes examined: 1 mETmOd(S) OF LYmPh nODE EXAmiNATION: 3 SENTINEL NODE METASTASIS: H/F stain SIZE OF NODAL METASTASES: Yes Lymph nODe metAstasis(-Es) wIth exTRAcApsuLaR exTensIOn: Diameter ef larges! lymph node metastasis: 1 rnm. METASTASES TO iPSILATERAL inTERNAL MAMMARy LYmPH NODE (IF APPLICABLE): No SKiN INVOLVED (ULCERATION): No NON-NEOPLASTIC BREAST TISSUE: ADH No t stage, pathologic: N stage. Pathologic: pT2 m Stage. PAThOlOgIC: pN1rni ESTrOGen rEcepTOrS: pMX PROGESTERONE RECEpTORS: positive HER2/NEU: positive zero or 1 r
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diff --git a/output/text/852eadde-de58-45cb-9cd2-81be7c92d48b.txt b/output/text/852eadde-de58-45cb-9cd2-81be7c92d48b.txt
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index 0000000000000000000000000000000000000000..eefce94ab6ed6463602fc867c26f0b616425e7cc
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+FINAL DIAGNOSIS: Part 1: Leet Breast. Segmental mastectOmy At 3 O'clOck -- A. TWO FOCI OF_INFILTRATING DUCTAL CARCINOMA, 0.7 AND 1.5 CM, NOTTHINGHAM SCORE 6/9 (TUBULES 3, nucleaR 2, mItOses 1). B. TumOR Aggregate 2.2 Cm. C. DUCTAL CARCINOMA IN SITU WITH COMEDO NECROSIS ASSOCIATED WITH MICROCALCIFICATION PRESENT in bOtH fOCI Of tUmOR AnD REPRESEnTing 10% Of The tumOR VOLumE. D. LYMPHOVASCULAR SPACE INVOLVEMENT IS NOT PROMiNENT. E. 1ND iNVASIVE TUMOR iS 0.2 CM FROM tHE ANTERIOR MARGIN AND DCIS iS 0.1 CM FROM ANTERIOR MARGIN. F. 2ND INVASIVE TUMOR IS 0.1 CM FROM THE POSTERIOR MARGIN. G. MARGINS fREE OF TuMOR. H. FIBROCYSTIC CHANGES WITH ATYPICAL DUCTAL EPITHELiAL HYPERPLASIA, SCLEROSING ADENOSIS ASSOCIATED WITH MICROCALCIFICATION. MICROSCOPIC RADIAL. SCAR, CONFIRMED BY POSITIVE P63 AND SMOOTH MUSCLE MYOSIN HEAVY CHAIn ImmunOSTaIn. 1cs-0 -3 Part 2: Left AxIlLA, Sentinel Lymph node #1, biOpsy -- Curcnomn, mfi1fnstmy dut,nos 85oof3  TWO LyMPH NODES NEGATIVE fOR TUMOR. Sif : buot No1 c50.9 3|13/n j PARt 3: LEFT AXILLA, SEnTinEL Lymph nOdE #2, BIOpSy  One Lymph nOde negaTive fOr tumOR. Case synupsis: SYNOPTIC - PRiMARY iNVASIVE CARCINOMA OF BREAST LATERALITy: procedure: Left LOcATIOn: Segmental SIZE OF TUMOR: Upper outer quadrant  Maximum dimension invasive component: 1.5 cm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: Yes TUMOR AGGREGATE SiZE: TUMOR TYPE (invasive component): Sum of the sizes of multiple invasive tumors: 2.2 cm NOTTINGHAM SCORE: Ductal adenocarcinoma, NOS Nuclear grade: 2 Tubule formation: 3 Mitotic activity score: 1 Total Nottingham score: 6 Nottingham grade (1, 2, 3): 2 UUID:2444E1FE-E0AB-4AA0-9081-967426890EE6 ANGIOLYMPHATIC iNVASION: TcgA-bh-A0bp-01a-pr Redacted DERMAL LYMPHATIC INVASION: No  Not applicable CALCIFICATION: Yes, benign zones Tumor type, in SiTu: Yes, malignant zones Solid Comedo DCIS admixed with invasive carcinoma SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: Percent of tumor occupied by in situ component: 10 % No SURG MARGINS INVOLVED BY IN SITU COMPONENT: Distance of invasive tumor to closest margin: 1 mm No LYMPH NODES POSITIVE: Distance of in situ disease to closest margin: 1 mm 0 LyMPH NODES EXAMINED: METHOD(S) OF LYMPH NODE EXAMINATiON: 3 SENTINEL NODE METASTASIS: H/E stain NON-NEOPLASTIC BREAST TISSUE: ADH, RadicaI scar, FCD No t stage, pathologic: pT1c N Stage, pathologic: m Stage, PathOlOgIC: pN0 ESTROGeN RECEPTORS: pMX PROGESTERONE RECEPTORS: previously performed HER2/NEU: previously performed zero or 1+ Criterl ase ls circ DisQ
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diff --git a/output/text/853c9f62-8dd2-40d8-9d15-ddfd90de3a9d.txt b/output/text/853c9f62-8dd2-40d8-9d15-ddfd90de3a9d.txt
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+/cD -0-3 caraima, viyftt^atng 1obule, Nos 8530/3 Site: breust, Nos. d50.9 8/7/1 Final Diagnosis Breast, right, modified radical mastectomy: Infiltrating lobular carcinoma, Nottingham grade II (of II1) [(tubules 3/3, nuclei 2/3, mitoses 2/3; Nottingham score 7/9], forming a mass (8 x 7.5 x 5 cm) located in the central breast [AJCC pT3]. The tumor does not involve the nipple, overlying. skin, or underlying chest wall. All surgical resection margins, including the deep margin, are negative for tumor (minimum tumor free margin, 1.3 cm, deep margin). Multiple (27 of 35) attached axillary lymph nodes are positive for metastatic carcinoma [AJCC pN3]. Lymph nodes, separately submitted right axillary level 3, excision: Metastatic adenocarcinoma is identified in multiple (2 of 4) lymph nodes.. Breast, Ieft, simple mastectomy: Benign proliferative fibrocystic changes characterized by sclerosing adenosis. Scattered calcifications are present in benign ducts. The nipple shows no diagnostic abnormalities. Estrogen and progesterone receptor analysis and Her-2/NEU have been ordered on paraffin embedded tissue. UUID:4E3FDA72-93E1-4961-B1DE-58FDAC7E9470 TCGA-AR-A2LH-01A-PR Redacted
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diff --git a/output/text/85674f3c-317c-455a-820f-720cd5e80299.txt b/output/text/85674f3c-317c-455a-820f-720cd5e80299.txt
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+Diagnosis: 1. : Right hemicolectomy preparation with tumor-free resection margins; in the area of Bauhin's valve and the ascending colon there are a few tubular and tubulovillous adenomas with focal to severe dysplasia (synonymously: profound intraepithelial neoplasia), together with a poorly differentiated, mucinous adenocarcinoma in the area of the right colic flexure with infiltration of the perimuscular adipose tissue and without regional lymph node metastases (G3, pT3 L0 V0 R0 pN0 0/26). 2. : Further tubular mucosal adenoma with moderate dysplasia (synonymously: mild intraepithelial neoplasia). 3. : Highly differentiated papillary mesothelioma (without any sign of malignancy) in the area of the small intestinal serous membrane.
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diff --git a/output/text/8582f26e-4ad8-4f28-aca3-5fc5612713d3.txt b/output/text/8582f26e-4ad8-4f28-aca3-5fc5612713d3.txt
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+1cD-0-3 Carcinema, hiji ltnofng oluctl, Nos 85oo/3 Pal Sih: brst uIQ c5o.2 1/25|u bw CQlF Site: brsot,Nos c5o.q Diagnosis: 1. Bifocal poorly differentiated invasive ductal carcinoma (tumor diameters: 2.5 cm and 0.7 cm) with focal intraductal components. Concluding tumor classification: NOS, G III, pT2(mult)N0(sn)L0V0R0 UUID: 2261B407-340D-4883-94BC-F06096FBDA80 Redacted TCGA-A8-A08B-01A-PR
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diff --git a/output/text/85a5f704-e885-4b9d-b486-f0a42be93271.txt b/output/text/85a5f704-e885-4b9d-b486-f0a42be93271.txt
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index 0000000000000000000000000000000000000000..2987af5f99f1b22a5009c2be19fbf1352c9bf601
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+SURGICAL PATHOLOGY REPORT * Addendum  Clinical Diagnosis & History: Colonoscopy found nearly obstructing hepatic flexure colon cancer and sigmoid cancer cT a scan shown mass at hepatic flexure colon previously. polypectomy at sigmoid colon. Hepatic flexure cancer and malignant polyp at sigmoid. Specimens Submitted: 1: Total abdominal colectomy 2: Proximal anastomotic ring 3: Distal anastomotic ring DIAGNOSIS: 1. Total abdominal colectomy: Tumor Type: Adenocarcinoma with mucinous features (<50% mucinous component). Histologic Grade:  Moderately differentiated Tumor Location: Hepatic flexure Tumor Size: Length is 4 cm Width is 5.5 cm. Maximal thickness is 0.4 cm Tumor Budding: Absent Increased Tumor Infiltrating Lymphocytes: Present Precursor Lesions: Tubulovillous adenoma Deepest Tumor Invasion: Subserosal adipose tissue and/or mesenteric fat Gross Tumor Perforation: Not identified Lymphovascular Invasion: Not identified Large Venous Invasion: Not Identified. Perineural Invasion: ** Continued on next page **
+
+--- Page 2 ---
+Page 2 of 5 Not identified Surgical Margins: Free of tumor Polyps/Mucosa Dysplasia (away from the carcinoma):. Not Identified Non-Neoplastic Bowel: Unremarkable Tattoo pigment is present consistent with the site of prior procedure Appendix: Unremarkable Lymph Nodes: Number with metastasis: 0 Total number examined: 43 Tumor deposits in pericolorectal soft tissue: Not Identified Tumor Staging (AJcc 7th Edition): pT3 (Tumor invades through the muscularis propria into pericolorectal tissues) Lymph Node Stage (AJcc 7th Edition):. NO (No reg Note: The results of immunohistochem stains for will be reported in an addendum. 2. Ileum, proximal margin; resection: -Segment of small intestine with no pathologic diagnosis. 3. Colon, distal margin; resection:. -Segment of colon with no pathologic diagnosis. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Special Studies: Result Special Stain Comment RECUT Gross Description: 1.) The specimen is received fresh, labeled "Total abdominal colectomy" and consists of a segment of terminal ileum, cecum with attached appendix and colon. The terminal ileum measures 7 cm in length and 3 cm in circumference ** Continued on next page **
+
+--- Page 3 ---
+ Page 3 of 5 the proximal resected margin. The remaining colon measures 70 cm in length with a circumference of 3.5 cm at the distal resected margin. The attached appendix measures 5 cm in length and averages 0.5 cm in diameter. The appendiceal and intestinal serosa is pink tan and smooth.. Focally hemorrhagic lobulated yellow tan adipose tissue spans the length of the specimen measuring up to 3 cm in thickness. The specimen is opened to reveal a mass lesion measuring 4 cm in length and 5.5 cm in width. The mass is located in the ascending colon, 18 cm from the proximal margin and 50 cm from the distal margin. Sectioning shows that the tumor invades the muscularis. The depth of invasion is 0.4 cm grossly.  The remaining mucosa shows numerous diverticula..  NO gross lesion is identified in the sigmoid colon. Two possible tattoo sites are present. One is 26 cm from the proximal margin and the other is 30 cm from the distal margin. The attached adipose tissue is thoroughly examined and all identified lymph nodes are submitted. Representative sections of the specimen are submitted. Summary of sections: P proximal margin shave distal margin shave tumor A appendix representative sections RS -representative sections LN - lymph nodes BLN - bisected lymph nodes ADD-tattoo sites 2).  The specimen is received in formalin wrapped around anastomotic tan labeled "proximal anastomotic ring." It consists of a ring of brown-tan mucosa with attached soft tissue, sutures, and staples measuring 1.7 x 1.5 x 1.0 cm. The mucosa is trimmed off and submitted entirely.. Summary of sections: U - undesignated 3). The specimen is received in formalin, labeled "Distal anastomotic ring" and consists of a ring of pink tan soft tissue measuring 3.0 x 1.8 x 1.7 cm. Multiple sutures and staples are attached.  The mucosal surface is pink tan and focally hemorrhagic. The sutures and staples are removed and the soft. tissue is entirely submitted.. Summary of sections: U - undesignated Summary of Sections: Part 1: Total abdominal colectomy ** Continued on next page **
+
+--- Page 4 ---
+Page 4 of 5. Block Sect. Site pCs 1 A 1 3 ADD 3 6 BLN 12 1 D 1 10  LN 30 1 P 1 2 RS  2 6 T 6 Part 2: Proximal anastomotic ring Block Sect. Site. PCs 1 u 1 Part 3: Distal anastomotic ring Block Sect. Site. PCs 1 u 1 Procedures/Addenda: Addendum Addendum Diagnosis Results of immunohistochemical staining for DNA mismatch repair proteins are as follows:. MLHl:Staining absent in tumor. MsH2:Staining present in tumor. MsH6:Staining present in . PMS2 : Staining absent in tumor Conclusion: Immunohistochemical stains for mismatch repair proteins demonstrate loss of expression on MLHl and PMs2. MSH2 and MSH6 expression are preserved. These results imply an underlying deficiency in DNA mismatch repair function.. Clinical correlation is suggested Addendum Comment ** Continued on next page **
+
+--- Page 5 ---
+Page 5 of  ** End of Report
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diff --git a/output/text/86348139-e689-4a87-ae0b-cbc40ff8fe45.txt b/output/text/86348139-e689-4a87-ae0b-cbc40ff8fe45.txt
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index 0000000000000000000000000000000000000000..9c4a0fd44488c28b26e87aa7dc94bdd525203419
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+Fomale D.O.B.: SPECIMEN INF ORMA HION Collected Accession  Recelved Acct I'Reg #: : - Reported: SURGICAI. PATHOLOGY REPORT UUID: 3D878253-22B3-4A53-AE54-C0D95E085D81 TcgA-AC-A2b8-01A-pr Redacted DIAGNOSIS DIAGNOSIS: A. Right axillary sentinel lymph node: One lymph node, no evidence of metastatic carcinoma.. Conflrms frozen sectlon dlagnosis and confirmed by negative staining for pancytokeratin. D. Right breee imaatacioidy 'Size: 8 cm. Architectural score: 3 of 3. Nuclear score: 2 of 3. Mitotic score: 1 af 3. Total score: 6 of 9 = grade 2 Carcinoma invoives portions of the nipple. No avidence of invotvement of the overlying epidermis.. Deep margin of excision is free of carcinoma..  pTNM classificatIon: T3pN0 (t) MX. Electronlc Signature: CLINICAL INFORMATION CLINICAL HISTORY: Preoperative Dlagnosis: Right modified radical mastectomy with sentinel node mapping with frozen section. Invasive Iobular carcinoma. ER positive, PR. positive, Ki-67 (MIB1) high - 28%. Postoperative Diagnosk: jcs-0-3 Symptoms/Radiologic Findings: SPECIMENS: A. Right axillary sentinel node #1300 with frozen section. S/H: brnst nos c50.9 8. Right breast 5/07" SPECIMEN DALA GROSS DESCRIPTION: Tho specimen is received in two containers, labaled with the patlent's name, Container A Is additionally labeied "right axllary sentinel node," and contains a 2.0 cm, yeliow-tan, firm. fattv nodule. It is bisected and entireiy submitted for frozen section. The residual is entirely resubmitted for permanent section in cassette A, labeled : Container B is recelved with fomalin, additionally labeled "right breast," and contalns an 685.4 gm. 19.0 x 13.5 x 7.5 cm, simple mastectomy speckmen,  partlalty surfaced by a 17.0 x 8.0 cm elipse of pink-tan wrinkied skin, bearing a central 0.9 x 0.9 x 0.5 cm inverted nipple. The deep margin is inked and.  the specimen is serially sectloned to roveal a 8.0 x 4.0 x 2.5 cm, ill-definod, gray-white gritty mass that resides 2.0 cm from the deep margin and 2.5 cm below the skin surface. The remainder of the cut surface is comprised of yellow-tan adlpose tissue admixed with moderate amount Af iniarenereed. gray-white Aibrous tissue. Additional masses are not identfiod. Representative sections are submitted in cassettes B1-11, labeled .. designated as follows: 1 -- nlpple; 2 -- Inked deep margin, perpendicular; 3-8 -- mass; 9-11 -- sections from the three uninvolved quadrants. Additionally a yellow and green cassette are submitted for genomics research, each labeled INTRA-OPERATIVE CONSULTATION: A. FROZEN SECTION DIAGNOSIS: *NegatIve for tumor," per Dr The sentinel node contains two small microscopic glands in the outer layer of the fibrous capsule of the node. I think they are benign glandular.  incluslons. Thoy stain with cytokeratin but they do not took like the invasive lobular carcinoma cells.
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diff --git a/output/text/863ad095-35a3-4807-bcdc-4ce6d156380c.txt b/output/text/863ad095-35a3-4807-bcdc-4ce6d156380c.txt
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index 0000000000000000000000000000000000000000..f7ea2c5051aa60747f795108c77cdf276498ed9e
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+
+--- Page 1 ---
+SPECIMENS: A. TERMINAL ILEUM AND RIGHT COLON B. GALLBLADDER DIAGNOSIS: A. RIGHT COLON AND TERMINAL ILEUM, RESECTION: - MODERATELY DIFFERENTIATED INFILTRATING COLONIC ADENOCARCINOMA (3.1 CM) EXTENDING INTO SUBSEROSAL FAT. SEE TEMPLATE. - SEVENTEEN BENIGN LYMPH NODES (0/17) - MULTIPLE TUBULAR ADENOMAS  - SURGICAL MARGINS, SMALL BOWEL AND APPENDIX ARE NOT INVOLVED B. GALLBLADDER, EXCISION: - CHRONIC CHOLELITHIASIS. COLORECTAL CANCER TEMPLATE Specimen Type: Right hemicolectomy Tumor Site: Ascending Colon Tumor Configuration: Exophytic Tumor Size: 3.1 x 2.5 x 0.6 cm Histological Type: Adenocarcinoma Histological Grade: Well differentiated Extent of Invasion: Focal subserosal adipose tissue. Margins: Uninvolved Distance to Closest Margin: Approximately 1.5 cm, radial. Angiolymphatic Invasion: Indeterminate Perineural Invasion: Absent Additional Findings:  Multiple tubular adenomas Extent of Resection: RO: Complete Lymph Nodes: Negative 0/17 Implants: Absent Pathological Stage: pT2 N0 MX SPECIMEN(S): A. TERMINAL ILEUM AND RIGHT COLON B. GALLBLADDER CLINICAL HISTORY:  None given INTRAOPERATIVE CONSULTATION DIAGNOSIS: FSA: Colon, right and terminal ileum, resection: 3 cm mass in ascending colon-10 cm from distal margin and 14 cm from proximal margin. By Dr, GROSS DESCRIPTION: A. TERMINAL ILEUM AND RIGHT COLON Received fresh is a curved segment of colon measuring approximately 24cm in length with a diameter up to 9.5cm. The serosal surface is unremarkable and there is an attached appendix measuring 6 cm in length with a diameter of 1.Ocm. The appendix shows no gross abnormalities. The specimen is opened and the ileum measures 7.3 x 4.2 cm with the ascending colon measuring 19.5 x 8.2 cm. There is a 3.1 x 2.5 cm oval sessile firm mass present in the ascending colon which is located 6.2 cm from the ileocecal junction, 10.0 cm from the distal colonic margin and 14.0 cm from the proximal margin. The mesocolonic fat is inked black and on sectioning the mass, it appears to invade into the submucosa. There are additional polyps located in the ascending colon, ranging in size from 0.3 to 0.6cm. Representative sections are submitted as follows: A1: proximal margin A2: distal margin A3: appendix A4: polyps A5-A9: mass including the deep margin
+
+--- Page 2 ---
+A10-A15: possible lymph nodes, ranging in size from 0.2 to 1.0cm.. A16: representative section of normal colon and normal ileum. A17: representative section of ileocecal junction. B. GALLBLADDER Received in formalin and labeled as "gallbladder" is an opened pink-tan gallbladder, measuring 7.5 x. 4.0 x 1.2cm. The serosal surface is smooth and is grossly unremarkable. The mucosal surface has a pink-tan coloration and a slightly granular/polypoid appearance. The gallbladder walls measure up to. 0.2cm. No masses or lesions are seen. Also submitted is an irregularly shaped black-gold stone measuring approximately 7.0 x 5.0 x 4.2cm. Representative sections are submitted in blocks B1-B2
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diff --git a/output/text/8656cb5f-8798-4d1c-bb96-710eecb5835d.txt b/output/text/8656cb5f-8798-4d1c-bb96-710eecb5835d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7ed37c902c83958c4fc93f797736e12637954ee9
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+path report Microscopic Sections demonstrate a moderately to markedly hypercellular neoplasm composed primarily of glial cells with round to oval nuclei with obvious. processes. There are numerous large neurons admixed within the tumor. Many appear maloriented and some are atypical. One possible binucleate neuron is. seen. These findings raise the possibility of ganglioglioma. However, no. eosinophilic granular bodies are seen. In this section, the tumor has a more overt, diffusely invasive architecture. Numerous dystrophic calcifications are seen. A finely branching vasculature is apparent focally, but definite oligodendroglioma differentiation with cells with perinuclear halos and few cytoplasmic processes are not seen. No mitotic figures are seen in more than 25 high power fields. Neither microvascular. proliferation nor necrosis are seen. The tumor cells do demonstrate a focally prominent angiocentric growth pattern.. Addendum Only a few p53 reactive cells are present, insufficient to definitely classify the tumor as astrocytoma. MiB-1 activity is variable throughout the tumor. In many areas the labeling index is only 2-3% consistent with a low grade tumor.. However, there are large areas with significantly higher proliferation. In these, a labeling index of 8.1% is calculated.. Diagnosis Anaplastic astrocytoma grade III
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diff --git a/output/text/866e0c45-9c3f-43f8-818c-947f3e250206.txt b/output/text/866e0c45-9c3f-43f8-818c-947f3e250206.txt
new file mode 100644
index 0000000000000000000000000000000000000000..bf0f5cdc6c25d50bed19ef6a99a3c0e8fc00bd45
--- /dev/null
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+SPECIMEN Right colon CLINICAL NOTES PRE-OP DIAGNOSIS: :  Right colon cancer GROSS DESCRIPTION Received fresh, labeled "right colon" is a previously. unopened, 23 cm. segment of proximal right colon with. attached 8 cm. of distal ileum surfaced by smooth to scabrous tan-pink serosa with a moderate amount of attached mesocolon, mesentery and unremarkable omentum. On opening, there is a well-circumscribed, 6.5 x 4.4 cm. centrally necrotic white pink-red. tumor mass 3 cm. distal to the ileocecal valve. On sectioning, the. lesion has a maximal thickness of 1.2 cm., grossly extending into the muscularis to within 0.4 cm.  of the inked free radial serosal surface. Two additional mucosal polyps averaging 0.5 cm. are present within the colon, 7.5 cm. proximal and 9 cm. distal to the. tumor. The remaining colonic mucosa is unremarkable, glistening. tan-pink with regular folds and the wall averages 0.4 cm in thickness. The ileal mucosa is unremarkable glistening tan pink with regular folds and the wall averages 0.4 cm. in thickness. The appendix is not present. A portion of tumor and a portion of normal mucosa are submitted for tissue procurement as requested. Several. soft tan-pink tissues in keeping with lymph nodes measuring up to 0.9 cm. in greatest dimension are recovered from the attached mesocolon and mesentery. Representative sections are submitted in. 12 blocks as labeled. Rs-12. BLOck suMmARy: 1 - Proximal and distal margins; 2, 3 - tumor full thickness to inked free radial serosal surface; 4 - central tumor; 5  tumor to normal mucosa; 6 - colonic polyp; 7 - Icv; 8 - random colon and ileum; 9-11 - six ole lymph nodes per cassette; 12 - five whole lymph nodes. MICROSCOPIC DESCRIPTION Histologic type:  Adenocarcinoma Histologic grade: Moderately to poorly differentiated. Primary tumor (pT): Tumor invades through the muscularis propria focally into the pericolonic fat (pT3). Proximal margin: Negative for tumor. Distal margin: Negative for tumor. Circumferential (radial) margin: Negative for tumor
+
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+Distance of tumor from closest margin: 11 cm. from proximal margin (ileum) Vascular invasion: Lymphatic space invasion is identified, best seen in slide 4, no venous or arterial space invasion is identified Regional lymph nodes (pN): 25 lymph nodes are dissected from the specimen, they were all negative for metastatic tumor (pN0) Non-lymph node pericolonic tumor: Not identified Distant metastasis (pM): Cannot evaluate pMx Other findings: Approximately 30% of the tumor has mucinous differentiation and is seen in blocks 4 and 5.  The most deeply invasive portion of the tumor is not mucinous and is poorly differentiated and seen in blocks 2 and 3. The ileocecal valve is. unremarkable. No appendix is identified. An additional tubular adenoma is noted in block 6. 5x1, 3260F DIAGNOSIS A. Colon, right, segmental resection:. Invasive adenocarcinoma, moderately to poorly differentiated, invasive into pericolonic fat (pT3) Lymphovascular space invasion present. 25 lymph nodes are negative for metastatic tumor (pN0). Additional adenomatous polyp..  End Of Report
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diff --git a/output/text/86a17b6f-e1b4-48e3-8f4c-7b3241e14e1a.txt b/output/text/86a17b6f-e1b4-48e3-8f4c-7b3241e14e1a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a2666fd8063b94607c13a89eb8037e7f9d024dc8
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+TSS: 1es-0-3 Cartinomo, rnfiltgHmg fobulw, Nos 85a0/3 SPECIMENS: PoM site: krst, nppw outw guodrent c50,4 A. SLN#1 LEFT AXILLA B. LEFT BREAST AND AXILLARY CONTENTS CQCFsjs: brst.Nb C50.9 H15 C. SENTINEL LYMPH NODE BX. RIGHT AXILLA D. SENTINEL LYMPH NODE #2 RIGHT AXILLA E. RIGHT BREAST & AXILLARY CONTENTS F. ADDITIONAL AXILLARY TISSUE SPECIMEN(S): A. SLN#1 LEFT AXILLA B. LEFT BREAST AND AXILLARY CONTENTS UUID:9AA68C63-2C14-430A-85C0-5A92F7FCCD36 C. SENTINEL LYMPH NODE BX. RIGHT AXILLA TCGA-E2-A1L8-01A-PR Redacted D. SENTINEL LYMPH NODE #2 RIGHT AXILLA E. RIGHT BREAST & AXILLARY CONTENTS F. ADDITIONAL AXILLARY TISSUE GROSS DESCRIPTION: A. SLN#1 LEFT AXILLA Received fresh is a tan white firm lymph node 2.6 x 2.1 x 1.4cm. The lymph node is serially sectioned and a portion of the specimen is submitted in FSA. A portion of the specimen is submitted for tissue procurement. The remainder of the specimen is submitted in A2-A3.. B. LEFT BREAST AND AXILLARY CONTENTS. STITCH IN AXILLA Received fresh is a 1651g oriented total mastectomy specimen 29.5 x 27.0 x 4.0cm. The specimen is partially surfaced with a tan brown ellipse of skin 26.5 x 11cm. The centrally located partially raised nipple is 0.9cm and the areolar rim is 1.2cm. The skin surface is remarkable for a well healed scar 1.5cm, 2.0cm from the nipple in the Upper Outer Quadrant. The specimen is inked as follows: Anterior/Superior-Blue, Anterior/Inferior-Orange, Posterior-Black. The specimen is serially sectioned from medial to lateral in to 13 slices; slice 1 being most medial, slice 13 being most lateral. The nipple is Iocated in slice 10. The cut surfaces reveal a gray white stellate mass 2.3 x 2.0 x 2.0cm in the UOQ and UCQ of slice 9, 10 and 11. The mass is greater than 2.0cm from the deep margin. The remaining breast parenchyma is grossly unremarkable. The axillary tail is 6.0 x 4.0 x 2.0cm. Dissection reveals 15 possible lymph nodes ranging from 0.3 x 0.2 x 0.2cm to 2.0 x 1.5 x 1.5cm. A portion of the specimen is submitted for tissue procurement. Representative sections are submitted as follows:. B1: nipple slice 10 B2: base of nipple slice 10 B3: skin with possible scar slice 8 B4: UIQ slice 7 B5: LIQ slice 7 B6: area adjacent to mass UiQ slice 8 B7-B8: mass UIQ slice 9 B9: deep margin slice 9 B10: superior/anterior margin slice 9 B11: inferior/anterior margin slice 9 B12-B14: mass slice 10 B15: deep margin slice 10 B16: mass UOQ slice 11 B17: deep margin slice 11 B18: LOQ with deep margin slice 11 B19: LOQ with inferior margin slice 12 B20: 5 lymph nodes 821: 5 lymph nodes B22: 3 lymph nodes B23: 1 lymph node serially sectioned B24: 1 lymph node serially sectioned C. SLN# 2 RIGHT AXILLA Received fresh is a tan white firm lymph node 1.5 x 1.0 x 0.6cm. The lymph node is serially sectioned and a portion of the specimen is submitted in FSC. The remainder of the specimen is submitted in C2. D. SLN # 3 RIGHT AXiLLA Received fresh is a tan white firm lymph node 0.9 x 0.6 x 0.4cm. The lymph node is serially sectioned and a portion of the specimen is submitted in FsD. The remainder of the specimen is submitted in D2. E. RIGHT BREAST AND AXILLARY CONTENTS
+
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+TSS: Received in formalin is an oriented simple mastectomy specimen weighing 1892 g and measuring 38.5 x 33 x 4.2 cm. There is a stitch designating the axillary tail. On the surface is an ellipse of brown-tan skin measuring 26.5 cm in length and 10.3 cm in width. The skin surface is unremarkable. The areola is 3.8 cm in diameter with an everted nipple measuring 1.4 cm. The anterior surface of the specimen is inked blue and the posterior/deep margin is inked black. The specimen is serially sectioned from medial to lateral. within the upper inner quadrant and 8 cm from the deep margin is a firm tan stellate lesion {#1} measuring 3.3 x 2.5 x 1.3 cm which extends into an hour-glass configuration. Approximately 2.3 cm lateral and inferior to this lesion is a firm tan stellate lesion {#2} measuring 1.3 x 1 x 0.8 cm. It is 3.8 cm from the anterior/skin. The remainder of the parenchyma is unremarkable. The axillary tail was serially sectioned and fixed in O-Fix. Two hemorrhagic lymph nodes are identified measuring 1.8 and 2.3 cm. Representative sections are submitted as follows: E1: Margin deep to lesion E2-E6: Lesion #1 submitted from medial to lateral E7-E8: Lesion #1and adjacent deep tissue E9: Tissue inferior to lesion #1 from blocks 7 and 8 E10: Left lateral portion of lesion #1 E11: Tissue inferior to block 10 E12-E15: Tissue adjoining lesion #1 and lesion #2 E16-E17: Lesion #2 E18-E19: Fibrous tissue from upper outer quadrant E20-E21: Fibrous tissue from lower outer quadrant E22-E23: Fibrous tissue from lower inner quadrant E24: Skin E25-E26: Nipple E27-E28: 1 lymph node each E29-E30: presumptive lymph nodes from the axillary region F. ADDITIONAL LEFT AXILLARY TISSUE Received in formalin is a piece of yellow-tan adipose tissue measuring 8.5 x 3.5 x 0.6 cm. Two lymph nodes are identified measuring 0.8 and 1.4 cm. Specimen is submitted entirely as follows: F1-F2: one lymph node each F3-F6: remainder of soft tissue DIAGNOSIS: A. LYMPH NODE, SENTINEL #1, LEFT AXILLA, BIOPSY: - METASTATIC CARCINOMA TO ONE OF ONE LYMPH NODE (1/1)  MEASURING 2-CM WITH EXTRANODAL EXTENSION. B. BREAST, LEFT, MASTECTOMY AND AXILLARY LYMPH NODE DISSECTION: - INVASIVE, LOBULAR CARCINOMA, SBR GRADE 2, MEASURING 2.2-CM - SURGICAL RESECTION MARGINS NEGATIVE FOR TUMOR - METASTATIC CARCINOMA TO ONE OF 12 LYMPH NODES (1/12) - SEE SYNOPTIC REPORT. C. LYMPH NODE, SENTINEL #2, RIGHT AXILLA, BIOPSY: - METASTATIC CARCINOMA TO ONE OF ONE LYMPH NODE (1/1), MEASURING 0.6-CM, WITH NO EXTRANODAL EXTENSION. D. LYMPH NODE, SENTINEL #3, RIGHT AXILLA, BIOPSY: - METASTATIC CARCINOMA TO ONE OF ONE LYMPH NODE (1/1). E. BREAST, RIGHT, MASTECTOMY AND AXILLARY LYMPH NODE DISSECTION: - INVASIVE, DUCTAL CARCINOMA, SBR GRADE 2, MEASURING 3.3-CM, PRESENT IN A BACKGROUND OF EXTENSIVE DUCTAL CARCINOMA IN SITU - INTERMEDIATE NUCLEAR GRADE, DUCTAL CARCINOMA IN SITU, CRIBRIFORM AND SOLID TYPES WITH CENTRAL NECROSIS, INVOLVING THE CENTRAL PORTION OF THE BREAST WITH EXTENSION TO MAJOR DUCTS OF NIPPLE, UPPER INNER AND LOWER INNER QUADRANTS - SURGICAL RESECTION MARGINS NEGATIVE FOR TUMOR - THREE LYMPH NODES, NEGATIVE FOR METASTASES (0/3) - SEE SYNOPTIC REPORT AND SEE NOTE.
+
+--- Page 3 ---
+TSS: F. LYMPH NODES, ADDITIONAL AXILLARY, DISSECTION: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1). NOTE: The right breast is involved by extensive DCiS. There are two grossly identified tumor masses, microscopically show invasive ductal carcinoma. The submitted tissue between these two masses. shows microscopic foci of invasive tumor as well as DCis. The largest confluent invasive tumor measures 3.3-cm. Breast biomarkers were ordered on the right breast tumor and addendum report to follow. These markers were reported on the needle biopsy of the left breast (). SYNOPTIC REPORT - BREAST Specimens Involved Specimens: A: SLN#1 LEFT AXILLA B: LEFT BREAST AND AXILLARY CONTENTS Specimen Type:  Mastectomy Needle Localization: No Laterality: Left Invasive Tumor: Present Multifocality: No WHO CLASSIFICATION Invasive lobular carcinoma 8520/3 Tumor size: 2.2cm Tumor Site: Upper outer quadrant Upper inner quadrant Margins:  Negative Tubular Score: 3 Nuclear Grade: 3 Mitotic Score: 1 Modified Scarff Bloom Richardson Grade:. 2 Necrosis: Absent Vascular/Lymphatic Invasion: None identified Lobular neoplasia: None Lymph nodes: Sentinel lymph node and axillary dissection. Lymph node status: Positive 2 / 13 Extranodal extension DCIS not present ER/PR/HER2 Results ER: Positive PR: Positive HER2: Negative by FISH Performed on Case: Pathological staging (pTN): pT 2 N 1a SYNOPTIC REPORT - BREAST Specimens Involved Specimens: C: SENTINEL LYMPH NODE BX. RIGHT AXILLA D: SENTINEL LYMPH NODE #2 RIGHT AXILLA E: RIGHT BREAST & AXILLARY CONTENTS F: ADDITIONAL AXILLARY TISSUE Specimen Type: Mastectomy Needle Localization:  No Laterality:  Right Invasive Tumor: Present
+
+--- Page 4 ---
+TSS: Multifocality: No WHO CLASSIFICATION Invasive ductal carcinoma, NOs 8500/3 Tumor size: 3.3cm Tumor Site: Upper inner quadrant Lower inner quadrant Central Margins:  Negative Tubular Score: 3 Nuclear Grade: 2 Mitotic Score: 2 Modified Scarff Bloom Richardson Grade: 2 Necrosis: Absent Vascular/Lymphatic Invasion: None identified Lobular neoplasia: None Lymph nodes:  Sentinel lymph node and axillary dissection Lymph node status: Positive 2 / 6 Extranodal extension. DCIS present  Margins uninvolved by DCIS DCIS Quantity: Estimate 75% DCIS Type: Solid Cribriform DCIS Location: Both associated and separate from invasive tumor mass. Nuclear grade: Intermediate Necrosis: Present ER/PR/HER2 Results ER: Pending PR: Pending HER2: Pending Pathological staging (pTN): pT 2 N 1a CLINICAL HISTORY:E year old post menopausal AA woman with abnormal screening mammogram and bilateral breast neoplasia. Left breast 2.5 x 1.5cm mass at 12:00 is invasive lobular Ca. Right breast with 2, 1cm foci of DCiS at 3 o'clock medial and subareolar position. No prior chemo.. PRE-OPERATIVE DIAGNOSIS: R and L breast Ca INTRAOPERATIVE CONSULTATION by FSA: Metastatic carcinoma extensively invoiving one lymph node. Diagnosis called to Dr. at Dr. FSC/FsD: Metastatic carcinoma extensively involving one lymph node. Diagnosis called to Dr at I by Dr. ADDENDUM: SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimens Involved Specimens: E: RIGHT BREAST & AXILLARY CONTENTS Specimen:  Surgical Excision Block Number: E6 ER: Positive Allred Score: 8 = Proportion Score 5 + Intensity Score 3 PR: Positive Allred Score: 6 = Proportion Score 4 + Intensity Score 2 COMMENT:
+
+--- Page 5 ---
+TSS: : The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cellis staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring. range from 0 to 8. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2.. METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Immunohistochemistry was performed using the mouse anti-human ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) provided by Following the manufacturer s instructions. This assay was not modified. Interpretation of the ER/PR immunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal review of staining performance. SYNOPTIC REPORT - BREAST HER-2 RESULTS Specimens Involved SpecimenS: E: RIGHT BREAST & AXILLARY CONTENTS Specimen:  Surgical Excision Block Number: E6 Interpretation: EQUIVOCAL Intensity: 2+ % Tumor Staining: 20% Fish Ordered: Yes , on Date METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours.  Her2 analysis was performed using the FDA approved HercepTest (TM) test kit ! 'sing rabbit anti-human HER2. This assay was not modified. External kit-slides provided by the manufacturer (cell lines with high, low and negative HER2 protein expression) and in- house known HER2 amplified control tissue were evaluated along with the test tissue. Adequate, well preserved, clear-cut invasive carcinoma was identified for HER2 evaluation. Interpretation of the HER2 immunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal review of staining performance. This assay has been validated according to the 2007 joint recommendations and guidelines from ASCO and CAP and from the NCCN HER2 testing in Breast Cancer Task Force. The Pathology Department takes full responsibility for this test's performance.. Additional presumptive lymph nodes from part E (right mastectomy) were submitted in 15 blocks, from E31 to E45. Three additional lymph nodes are identified, negative for metastasis (0/3).. PathVysion HER-2 DNA Probe Kit Case No Analytical Interpretation of Results: HER-2 NOT AMPLIFIED Clinical Interpretation of results Amplification of the HER-2 gene was evaluated with interphase fluorescence in-situ hybridization (FisH) on formalin-fixed paraffin embedded tissue sections using a chromosome  17 centromeric probe and a HER-2 probe that spans the entire HER-2 gene in the 3y Dr. majority of tumors cells displayed extensive polysomy 17. with 4 to 8 chromosome 17 signals and 4 to 8 HER-2 signals, with a HER-2/CEP 17 Ratio </=2.0, consistent with no amplification of the HER2/neu gene. Block usedE6 Source of case: Tissue fixation formalin-fixed tissue Outside Case No:NA Tissue source breast Results interpreted: yes HER2/CEP17 ratio: 0.95 This ratio is derived by dividing the total number of LSI HER-2/neu signals by the total number of CEP17 signals in at least 20 interphase nuclei with nonoverlapping nuclei in the neoplastic
+
+--- Page 6 ---
+TSS: :  mammary epithelial cells. Cells with no signals or with signals of only one color are disregarded.. Method of ratio enumeration: manual count Limitations The Vysis PathVysion Kit is not intended for use to screen for or diagnose breast cancer. It is intended to be used as an adjunct to other prognostic factors currently used to predict disease-free and overall survival in stage Il, node-positive breast cancer patients. In making decisions regarding adjuvant CAF treatment, all other available clinical information should also be taken into. consideration, such as tumor size, number of involved lymph nodes, and steroid receptor status.. No treatment decision for stage II, node-positive breast cancer patients should be based on HER-. 2/neu gene amplification status alone. Overview of this test FDA APPROVED REAGENT  PathVysion HER-2 DNA Probe Kit is FDA approved for selection of patients for whom Hercentin theraov is being considered. These tests were performed in the under the direction of Dr.. The resuits of these studies should always be interpreted in the context of the clinical, morphological, and immunophenotypic diagnosis. Gross Dictation: Pathologist,  Microscopic/Diagnostic Dictation: Pathologist, ( Final Review: Pathologis Final Review: Pathologis Final: Pathologist, C Addendum: Patholoyist, Addendum Final: Pathologist, I Addendum: Pathologist, 0 Addendum Final: Patholoqis Addendum: Pathologist Addendum Final: Pathologist,
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diff --git a/output/text/86c15b10-5ef3-4f78-9d2b-3a39aef980b2.txt b/output/text/86c15b10-5ef3-4f78-9d2b-3a39aef980b2.txt
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index 0000000000000000000000000000000000000000..63510fd5e34bd90b38db62d4a2d4433194dfc874
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+FINAL DIAGNOSIS: Part 1: Leet Breast, Segmental mastectomy - A.  InVasive DUctaL CArcinOmA, nOTTingham SCORE 8/9 (tuBuLES 3, nUcleI 3, mItOSiS 2), 2.6 Cm. B.  DUctAL CARcinOma iN Situ, micROpapiLLAry anD SOLid Types wiTh COmeDO necROsIS, nucLeAR GRADe 3, REPRESENTING 5% Of thE TumOR VOLUmE C. LYMPHOVASCULAR SPACE INVOLVEMENT SEEN. D. INVASIVE CARCINOMA IS 0.1 CM FROM INFERIOR MARGIN. E. DUCTAL CARCINOMA IN SITU IS <0.1 CM (1MM) FROM INFERIOR MARGIN. MARGINS FREE OF LESION G.  MICROCALCIFICATION ASSOCIaTED WiTH BENIGN ChAnGeS AnD TUmOR. H. CHANGES CONSISTENT WITH BIOPSY SITE PROLiFERATIVE FIBROCYSTIC CHANGES WITH ATYPICAL DUCTAL EPITHELiAL HYPERPLASIA AND COLUMNAR CELL CHANGES. J.  MICROSCOPIC PERIPHERAL PAPILLOMA AND SCLEROSING ADENOSIS. K. SKIN NOT REMARKABLE. part 2: Left AxILlA, Sentinel Lymph nOde #1, excision - A. One Lymph node positive for metastatic Carcinoma (0.9 Cm). B. NO extracapsulaR extensiOn Seen. Part 3: Left AxillA, Sentinel Lymph node #2, excision -- ONE LYMPH NODE WiTH RARE CLUSTERS OF METASTATIC TUMOR CELLS IN PERIPHERAL SINUS. PArt 4: LEft AxiLLA, Lymph nODe exciSiOn - One lymph node with extensive thermal effect, probably free Of tumor. /cs-0-3 CASE SYNOPSIS: Caicinonra, lupitnatry Cutul, Nos 8500j3 SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST LATERALITY: Sit: brut, nos C50.9 3%3fu h Left proceDure: Segmental LOCATION: Lower outer quadrant SIZE OF TUMOR: Maximum dimension invasive component: 2.6 cm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: No TUMOR TYPE (invasive component): Ductal adenocarcinoma, NOS NOTTINGHAM SCORE: Nuclear grade: 3 Tubule formation: 3 Mitotic activity score: 2 Totai Nottingham score: 8 Nottingham grade (1, 2, 3): 3 ANGIOL YMPHATIC INVASION: UUID:A997FF30-F112-48BE-8FF1-15F8266A5E620 Yes TCGA-BH-A0GY-01A-PR Redacted DERMAL LymPHATiC iNVASION: No CALCIFICATION: Yes, benign zones Tumor type, in situ: Yes, malignant zones SOuu  Micropapillary Comedo DCIS admixed and outside of invasive carcinoma component Percent of tumor occupied by in situ component: 5 %. SURGICAL MARGINS INVOLVED BY iNVASIVE COMPONENT: No Distance of invasive tumor to closest margin: 1 mm. SURG MARGINS INVOLVED BY IN SITU COMPONENT: No Distance of in situ disease to closest margin: 0.7 mm. Paget's diseaSe Of nipple: No Lymph nodes positive: 2 LYMPH NODES EXAMINED: 3 METHOD(S) OF LymPh nODE EXAMINATION: H/E stain SENTINEL NODE METASTASIS: Yes SIZE OF NODAL METASTASES: Diameter of largest lymph node metastasis: 9 mm. LyMPH NODE METASTASIS(-ES) WITH EXTRACAPSULAR EXTENSION: No SKIN INVOLVED (ULCERATION): No NON-NEOPLASTIC BREAST TISSUE: ADH, Papilloma, FCD t Stage, pathologIC: pT2 N stage, pathologic: pN1a m Stage, patholOgiC: pMX EsTROgen rEcepTOrS: positive PROGESTERONE RECEPTORS: positive Herdineil.
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diff --git a/output/text/86e7d98a-159f-47c6-bf1d-e071e0678820.txt b/output/text/86e7d98a-159f-47c6-bf1d-e071e0678820.txt
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+
+--- Page 1 ---
+SPECIMENS: FS1 LEFT CERVICAL LEVEL 5 L.N, CLINICAL HISTORY:  FNA - malignant histology FINAL DIAGNOSIS: LYMPH NODE, LEFT CERVICAL, LEVEL 5, biopsy: MALIGNANT LYMPHOMA, DIFFUSE, LARGE CELL TYPE (IWF G1), B-CELL PHENOTYPE. See note. DIAGNOSIS COMMENT: A preliminary flow cytometric report indicates that the lymphoma cells are positive for CD19, CD20 and CD22, with a Kappa/Lambda ratio of 59.9/0.23. FROZEN SECTION DIAGNOSIS: FS1: Malignant lymphoma by Dr. Comment: Seen in consultation with Dr. who concurs with the diagnosis. Dx called to Dr. on GROSS DESCRIPTION: FS1 LEFT CERVICAL LEVEL 5 LYMPH NODE: Received are two tannish nodular masses measuring 3x2x2 and 4x3x2 cm. The cut surface reveals a tannish fleshy and faintly Iobulated surface. Samples were taken for cytogenetic tissue procurement and frozen tissue for IHC. The remaining portions were submitted in B5 and formalin. Representative sections are submitted as follows: FS1-frozen section, F1 and F2-tissue fixed in formalin, B51 and B52-tissue fixed in B5 fixative. Date of surgery
+
+--- Page 2 ---
+SPECIMENS: BM BX RA BM BX LA FINAL DIAGNOSIS: BONE MARROW, right and left iliac crest biopsies, sections,. imprints and smears: ORDERLY HEMOPOIESIS. Negative for lymphoma DIAGNOSIS COMMENT: [BBone Marrow 1: Asp & Bx (No cytochem)b Pt. Data: Hgb 14.6 WBC 5.38 Plat. 273.0 I. qUAspirate - Differential(u(%): Cells Counted 500 Cellularity estimate 2+ M:E 1.8/1 Megakaryocytes: Dysplasia: Grade 0 Quantity: Normal |UMyeloid cells|u|U Monos/Lymphs|u |UErythroid cells/Other|u Dysplasia Grade 0  Dysplasia Grade 0 2.6 myeloblasts NG monoblasts 0.2 pronorm. 1.6 promyelocytes NG promonocytes 33.4 normoblasts. 12.0 myelocytes 0.8 monocytes  NG sideroblasts * 13.4 metamyelocytes 4.2 lymphocytes NG ring siderobl.**. 13.0 bands/stabs NG lymphoblasts0.2 plasma cells 15.2 segs NG abnormal lymphs NG histiocytes. 3.4 eosinophilic NG unclass. blasts NG other NG basophilic 62.0 TOTAL myeloid & mono *: as % of normoblasts: **: as % of all nucleated cells. Comment on Diff: Normal hematopoiesis II.JU Biopsy datalu: Cellularity: 0-50%, average 35% 1 2. Myeloid/erythroid ratio: 2/1  Myeloid series: Dysplasia: Grade 0 Quantity: Adequate 4. Erythroid series: Dysplasia: Grade 0 Quantity: Adequate 5.  Megakaryocytes: Dysplasia: Grade 0 Quantity: Rare 0-4/hpf 6. Iron stores: NG 7. Abnormal infiltrate: None Other: 9.  Comparison to Previous Bx: N/A GROSS DESCRIPTION: 1. 8M BX RA Received in B5 in container labelled with patient name is a brown tan fragment of bone measuring 0.9x0.2x0.2cm. Submitted in toto. 2. BM BX LA Received in B5 in container labelled with patient name are two brown tan fragments of bone aggregating to a. Iength of 1.Ocm. Submitted in toto.
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diff --git a/output/text/86e8ce57-425e-46cd-b862-4690fb763682.txt b/output/text/86e8ce57-425e-46cd-b862-4690fb763682.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1f706a39c688345b14b8e109272f963be3c6358c
--- /dev/null
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@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+Results Surglcal Pathology (enter 1 per line): Specimen #1 LEFT HEPATIC ARTERY LYMPH NODE for perm Result Information Status (Last updated Date/Time) Accession# Racult Imnreceian UUID:B39186EA-425D-411D-AA4C-EE43B861E807 TCGA-UB- Redacted ICD-O-3 SURGICAL PATHOLOGY REPORT LoeF sepatoceIlulsr NOS areunono 817013 Patient Name. Med. Rec.#.. hepatocllulor erenonb.. DOB: pleomophie 81 7573 Sex: Male Soc. Sec. Accession #: snir CQ2.0 Site:  Visit #: Service tJ 91ae|I3 Receive Locatic Client: Physici FINAL PATHOLOGIC DIAGNOSIS A. Lymph node, left hepatic artery, biopsy: No tumor in one lymph node (0/1). B. Lymph node, cystic artery, biopsy: No tumor in one lymph node (0/1). Gallbladder, cholecystectomy: Focal mucosal autolysis, otherwise no significant pathologic abnormality. D. Lymph node, portal caval, biopsy: No tumor in one lymph node (0/l). E.. Liver, right lobe, partial hepatectomy: 1. dimension, moderately to poorly differentiated with vascular invasion, margins negative; see comment 2. Chronic hepatitis B (activity grade 1, fibrosis stage 2); see comment. COMMENT : Liver Tumor, Including Intrahepatic Bile Duct, Synoptic Comment - Tumor type: Hepatocellular carcinoma: mixed type with trabecular,
+
+--- Page 2 ---
+pleomorphic, and pseudoglandular areas..  Histologic grade: Moderately to poorly differentiated. Tumor size (maximum diameter of largest lesion): 9 cm. - Tumor necrosis: <l0%. - Multifocality (more than one tumor separated by nontumorous liver parenchyma): Present. Estimated total tumor diameter of all Hcc foci: 16 cm. Vascular invasion: Present.in small vessels (slide E5). - Hepatic capsule: Tumor abuts capsule. - Local extension of tumor: Confined to liver.  Hepatic surgical margins: Negative; tumor is 0.9 cm from the surgical resection margin. - The tumor is within 4 mm of the diaphragm and within 0.5 mm of the site marked ivc sidewall. - Non-neoplastic liver: Hepatitis B.. Iron stain: Negative (performed and evaluated on block Eio). - Hepatocellular nodules (in cirrhotic liver): None. - Lymph node status: Negative; total number of nodes examined: 3. - AJcc Stage: pT3an0. To further characterize the background liver, immunohistochemical stains for hepatitis B virus surface and core antigens were obtained on sections of non-neoplastic liver (block El0). Hepatocytes showed diffuse staining for hBv surface antigen and were negative for core antigen, supporting a diagnosis of chronic Hepatitis B. Trichome stain was performed on block E10 and highlights the presence of septal fibrosis with occasional bridging fibrosis without architectural distortion, consistent with an overall fibrosis stage 2. Immunostain for vascular marker (ERg) was performed and evaluated on block E5 and confirms the diagnosis of vascular invasion.. has reviewed slides E5 and E7 (H&E and ERG stains) and agrees with the diagnosis of vascular invasion. The immunoperoxidase stain(s) reported above were developed and their performance characteristics determined by the  They have not been cleared or approved by the U. S. Food and Drug Auninistration. The FDA has determined that such clinical purposes. They should not be regarded as investigational or for research. This laboratory is certified under the Clinical. Laboratory Improvement Amendments of 1988 ("cLIA") as qualified to perform high-complexity clinical testing. Specimen(s) Received A:left hepatic artery lymph node. B:cystic artery lymph node. C:gallbladder D:portal caval lymph node E:right hepatectomy with partial diaphragm Clinical History Collection Time:
+
+--- Page 3 ---
+Relevant History: yo w/hx of HBv (recently started Tenofovir) who complained of right groin pain. Workup included a cT scan. that demonstrated a large liver mass. The case was discussed at. liver tumor board with recommnedations to pursue surgical resection. The patient is a year-old man with a history of hepatitis B virus (recently started Tenofovir) and heavy alcohol use. cT scan on showed a large liver mass. He is now undergoing resection. According to imaging found a bilobed, heterogeneously enhancing mass. centered in segment 7 of the liver. The mass is partially exophytic and  has contact with the right hemidiaphragm. There is mass effect on the Ivc and on the right hepatic vein. Gross Description The case is received in five parts, labeled with the patient's name and. medical record number. Part A is received fresh and additionally labeled "left hepatic artery LN," and consists of a single intact, ovoid lymph node (1.1 x 0.6 x 0.5 cm). The node is bisected to reveal a grossly unremarkable, solid, tan-pink cut surface. The nodes is submitted in its entirety in cassette Al. Part B is received fresh and additionally labeled "cystic artery LN," and consists of a single tan-brown, ovoid, intact lymph node (l.1 x 0.6 x 0.3 cm) with scant attached soft, yellow fibroadipose tissue. The node is bivalved to reveal a grossly unremarkable, solid, tan-pink cut surface. The node is submitted in its entirety in cassette Bl. Part C is received fresh and additionally labeled "gallbladder," and consists of an intact gallbladder (5.5 cm in length, 2.1 cm in diameter at fundus, 1.l cm diameter a neck). The gallbladder is bright-green and has a smooth and glistening serosal surface. The adventitial surface is dull and ragged but intact. The cystic duct margin measures 0.5 cm in outside diameter and is free of impacting calculi. The gallbladder contains thin, green bile and is devoid of stones. The gallbladder wall is. thin and pliable, of even thickness (0.2 cm) and free of any areas of induration. The gallbladder mucosa is. green and velvety, free of any areas of ulceration or polyps. No cystic duct lymph node is identified. Representative sections, including the inked cystic duct margin, are submitted in cassette cl. Part D 'is received fresh and additionally labeled "portal caval LN," and. consists of a single intact, ovoid lymph node (1.6 x 0.8 x 0.7 cm) with a scant amount of attached yellow, lobulated adipose tissue. The node is sectioned to reveal a congested but otherwise grossly unremarkable, tan-pink cut surface. The node is submitted in its entirety in cassette Dl. Part E is received fresh and additionally labeled "right hepatectomy with partial diaphragm," and consists of a portion of liver (885 gm;. 13.5 cm from right to left x 11 cm from anterior to posterior x 18 cm from superior to inferior). There is an exophytic mass on the superior. surface, which has been cut in to prior to recept by Pathology, and harvested for banking by  The mass is soft, yellow-gold and homogenous (7 x 6 x 6 cm), and is within 0.l cm of the capsule and 0.7 cm from the surgical resection margin. There is a second lesion adjacent to the first lesion, which is larger and appears to be a distinct lesion, and is soft, yellow-gold and focally hemorrhagic (9 x 6.
+
+--- Page 4 ---
+x 6 cm) and is 1.4 cm from the surgical resection margin. There is a vessel running between the two lesions, which does not appear to be involved. There is an oval white-tan fragment of diaphragm on the superior surface of the specimen. The tumor appears to be abutting, but does not invade the diaphragm. The remainder of the hepatic parenchyma is firm, red-brown and without nodules. ORIENTED BY : Surgeon's sutures (black short stitch = sidewall of vena cava, black long stitch = right hepatic vein). INKING: Surgical margin: Black. - Right hepatic vein: Yellow. - Sidewall vena cava: Green.  Diaphragm: Green. CASSETTES: Representative sections are submitted as follows: E1: Right hepatic vein margin. E2 : Vessel between lesions.. E3: Lesion #l, closest approach to capsule. E4: Lesion #1, closest approach to diaphragm. E5: Lesion #l, with adjacent normal parenchyma. E6: Lesion #2. E7: Lesion #2, with adjacent normal. E8: Lesion #2, closest approach to capsule. E9: Lesion #1. E10: Uninvolved hepatic parenchyma.. E11: Lesion #l with Ivc sidewall.. Diagnosis based on gross and microscopic examinations. Final diagnosis made by attending pathologist following review of all pathology slides. The attending pathologist has reviewed all dictations and preliminary interpretations performed by any resident involved in the case and performed all necessary edits before signing the final report. Electronically signed. out or. Pathology PDF Report Show images for Surgical Pathology (enter 1 per line): Specimen #1 LEFT HEPATIC ARTERY LYMPH NODE for perm Authorizing Provider Information Name: Phone: Signed by. Phone Pager Signed Result History SURGICAL PATHOLOGY Surgical Pathology. (enter 1 per line): Specimen #1 LEFT HEPATIC ARTERY LYMPH NODE for perm This is NOT a Requisition. Requisition hyperlink below.
+
+--- Page 5 ---
+Surgical Pathology (enter 1 per line): Specimen #1 LEFT HEPATIC ARTERY LYMPH NODE for perm Authorizin Pathology and Cytology Departmel Show images for Surgical Pathology (enter 1 per line): Specimen #1 LEFT HEPATIC ARTERY LYMPH NODE for perm Order Information. Order Date/Time Release Date/Time Start Date/Time End Date/Time Release Information Released On  Released By Order Details Frequency Duration  Priority Order Class Once 1 occurrence Routine Unit Collect Order Questions Question Answer Comment Specimen (enter 1 per line) Specimen #1 LEFT HEPATIC ARTERY LYMPH NODE for perm yo w/hx of HBV (recently started Tenofovir) who complained of right groin pain. Workup included a CT scan that demonstrated a Iarge liver mass. The case was discussed a: liver tumor board with recommnedations to pursue surgical resection. Lab Collection and Receipt Information Collect Date Collect Time Collected By Lab Receipt Date  Lab Receipt Time Collection Information Resulting Agency
+
+--- Page 6 ---
+Order Provider Info. Office phone Pager/beeper E-mail Ordering User Authorizing Provider Billing Provider Electronically Signed By:. Electronically Authorized By Electronically Ordered By Acknowledgement Info Acknowledged By Acknowledged On For At Order Status for: SURGICAL PATHOLOGY Parent Status: Completed Child Orders (This order does not yet have any children). Order Requisition. Surgical Pathology (enter 1 per line): Specimen #1 LEFT HEPATIC ARTERY LYMPH NODE for pern lw g|3r19 uror Site Discrepan
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diff --git a/output/text/8718c2e1-0ff7-4aa9-8ad6-5959bc53fd5b.txt b/output/text/8718c2e1-0ff7-4aa9-8ad6-5959bc53fd5b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..912b867330aa498aa288049e2abea783dd5f4184
--- /dev/null
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+
+--- Page 1 ---
+TcD0-3 ereentns, yeopeleryneno TCGA-Y8-A894-01A-PR Redacted 836ol 3 c e.0Q C64.9 Research Gross Description tJ il [22]!3 female with left renal lesion Research Dx CASE SUMMARY FOR NEPHRECTOMY FOR RENAL CELL CARCINOMA: Procedure: Partial nephrectomy Specimen laterality: Left Tumor site: Middle pole Tumor size: 1.8 cm Extent of disease: Tumor limited to the kidney Histologic type: Papillary renal cell carcinoma, type 1. Sarcomatoid features: Not identified Tumor necrosis: Not identified Histologic grade (Fuhrman Nuclear Grade): 2 Margins: Negative Lymphovascular invasion: Not identified Pathologic staging (pTNM): - Primary tumor: pT1a (tumor less than 4 cm in greatest dimension, limited to the kidney) Regional lymph nodes: No lymph nodes are submitted. Number examined: 0 Numer involved: Not applicable Distant metastasis: pM-not applicable Pathologic findings in nonneoplastic kidney: Peritumoral chronic inflammation; foci of interstitial chronic inflammation with scattered sclerosed glomeruli and arterial nephrosclerosis Other tumors and/or tumor-like lesions: None AJCC Staging (7th edition) pT1a pNX pM-not applicable Research QC Tumor: 100% tumor nuclei 0% necrosis 0% normal Normal: 99% kidney, small papillary carcinoma probable floater 1%. Specimen Process Time Blood draw time:. Plasma frozen time: Serum frozen time: Buffy coat frozen time: Cold ischemia start time: Formalin fixation start time: Total cold ischemia time Formalin fixation stopped time: Total formalin fixation time:
+
+--- Page 2 ---
+Specimen Weight  Normal  1-170 mg, 2-110 mg Tumor 1-150 mg, 2-130 mg Specimen Size Plasma x 3 Serum x 3 Buffy coat x 1 Cryovials x 4 Normal x 2 Tumor x 2 FFPE x 4 Normal x 2 Tumor x 2 Studv Patient Consent Yes 3
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diff --git a/output/text/871c7f4c-2911-493d-a724-6a8d13c4e178.txt b/output/text/871c7f4c-2911-493d-a724-6a8d13c4e178.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5b758876c2ff8055e2964b1ba18a97c6693b0560
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+TSS ID: TSs ID: Oc iD:s Date of Procurement: Gross Description:  Lump with the tumor of 1 x 1.8 cm in size; fatty tissue lymph nodes are dense, hyperemic. Microscopic Description: Infiltrating duct carcinoma; G2. Focal hyalinosis. Ten lymph nodes were examined, four lymph nodes demonstrated metastses. Diagnosis Details: Tumor Features: Unknown, Tumor Extent: T1 tumor size 2 cm or less, Venous Invasion: Absent, Margins: Absent, Treatment Effect: Comments:a 1cs-0-3 Carcii oma ni fiAtrotiny cluct, Nes sI5ovf3 Site; brsot, Nos C50-9 Formatted Path Report: 4/8/1 BREAST TISSUE CHECKLIST Specimen type: Lumpectomy Specimen size: Not specified Tumor site: Upper outer quadrant. Tumor size: 1.8 x 0 x 1 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinoma. Histologic grade: Moderately differentiated Tumor extent: Not specified Lymph nodes: 4/10 positive for metastasis (Axillary 4/10) Extracapsular invasion of the lymph nodes: Not specified Margins: Uninvolved Nottingham Histologic Score UUID: 59D84893-8946-4C5C-A338-3E33A1F7DE000 TCGA-E9-A1RG-01A-PR Redacted Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined
+
+--- Page 2 ---
+TSS 1D Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None Laterality: Right, upper outer quadrant.
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diff --git a/output/text/87d3c07b-c538-4edb-8a79-7ab70771213f.txt b/output/text/87d3c07b-c538-4edb-8a79-7ab70771213f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d56d2479fc0c730e3a31b751c7242ad7f344a6c5
--- /dev/null
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+
+--- Page 1 ---
+UUID: B58C2E00-6E35-4A56-AF0D-0A62335BBD89 TCGA-MQ-A4LV-01A-PR Redacted  Result type: Report Result date: 'Result status: Auth (Verified) Result titfe: SPECIMEN DESCRIPTION Performed by: * Final Report * 1cs-0-3 Msothli'oma, epiHelioil, nos 9osH3 SPECIMEN DESCRIPTION Site: plurs, Nos C38.4 LEFT LUNG LEVEL 10 LYMPH NODE MEDIALSTINAL FAT 10/4/12-- BRONCHIAL MARGINS THORACOSCOPY SITE 1 POSTERIOR THORACOSCOPY SITE 2 ANTERIORS LEVEL 7 LYMPH NODE SURGICAL PATHOLOGY REPORT LOCATTON: PATHOLOGY NO.: HOSPITAL ID: PATIENT ID: .IOSPITAL NO.: PATIENT'S NAME: ACCOUNT NO.: AGE/SEX/DOB: M DATE RECEIVED: PHYSICIAN(S) : DATE OF PROCEDURE: COPY TO: ACCN REQ. NO.: NOT GIVEN REFERRING PHYS: ATTENDING PHYS: DIAGNOSIS: LEFT LUNG PNEUMONECTOMY:  MALIGNANT MESOTHELIOMA, SOLID, EPITHELIOID AND SARCOMATOUS PATTERS DIFFUSELY INVOLVING THE PLEURA, PARIETAL AND VISCERAL WITH DIRECT EXTENSION INTO THE LUNG PARENCHYMA, ADHERENT TO THE DIAPHRAGM SLIGHTLY AND FOCALLY INFILTRATING THE SKELETAL MUSCLE AND ALSO INVOLVING THE MEDIAL PLEURA AND ADHERENT PARIETAL PERICARDIUM. MMOR ENDS BRONCHIAL MARGIN OF RESECTIONS NEGATIVE FOR TUMOR. NINE REGIONAL LYMPH NODES ARE IDENTIFIED AND THEY ARE NEGATIVE FOR TUMOR.THEY SHOW SINUS HISTIOCYTOSIS, ANTHRACOTIC PIGMENTATION AND REACTIVE FOLLICULAR HYPERPLASIA. (SEE COMMENT). B. LEVEL 1O LYMPH NODE: ONE LYMPH NODE NEGATIVE FOR TUMOR. IT SHOWS SINUS Printed by: Page 1 of 5 Printed on: (Continued)
+
+--- Page 2 ---
+ HISTIOCYTOSIS, ANTHRACOTIC PIGMENTATION, CONGESTION AND REACTIVE FOLLICULAR HYPERPLASIA. LABELED AS MEDIASTINAL FAT: SIX LYMPH NODES ARE IDENTIFIED AND ARE NEGATIVE FOR TUMOR. D. LABELED BRONCHIAL MARGIN: BRONCHIAL MARGIN NEGATIVE FOR TUMOR. E.  LABELED THORACOSCOPY SITE #1 POSTERIOR: SKIN WITH CUTANEOUS SCAR AND ATTACHED SKELETAL MUSCLE, NEGATIVE FOR TUMOR. F.  THORACOSCOPY SITE #2, ANTERIOR: SKIN WITH CUTANEOUS SCAR, NEGATIVE FOR TUMOR. THEY G.  LABELED LEVEL 7 LYMPH NODES: FOUR LYMPH NODES NEGATIVE FOR TUMOR. SHOW SINUS HISTIOCYTOSIS, CONGESTION, ANTHRACOTIC PIGMENTATION AND REACTIVES FOLLICULAR HYPERPLASIA. coMmEnT: The pleura (parietal and visceral) is diffusely thickened involved with malignant mesothelioma.  It also involves the pleura at the diaphragmatic surface and is adherent to the diaphragm. It slightly and focally infiltrate the skeletal muscle. Medially, the pleura is also involved with tumor and it involves the adherent parietal pericardium. The tumor appears solid, made up. of masses of polygonal  cells and spindle cells with desmoplasia and marked chronic inflammation with areas of necrosis. There focal areas of papillary pattern.  The tumor focally infiltrates into the lung parenchyma. ' The. interlobar pleura is also involved and also here the tumor infiltrates into the  The lung parenchyma shows edema, acute and chronic passive. lung parenchyma. congestion,  focal scattered chronic pneumonitis and moderate sclerosis of. vessels. No thrombi are identified in the small and large vessels. Several The lymph nodes are identified and are all negative for metastatic tumor. nodes show sinus histiocytosis, congestion, anthracotic pigmentation and reactive follicular hyperplasia.  The bronchial margin of resection is negative for tumor. Immunostains for the tumor cells are. done on two blocks to include: calretinin-positive: ck5/6-positive; keratin- positive; vimentin-positive; CEA-. negative;  S100-negative, and BER EP4- negative; B72.3- negative; TTF-1-negative. The results of these special stains supports the diagnosis of MESOTHELIOMA. SPECIMen: LEFT LUNG B LEVEL 10 LYMPH NODE c MEDIASTINAL FATS D BRONCHIAL MARGINS E THORACOSCOPY SITE 1 POSTERIOR E THORACOSCOPY SITE 2 ANTERIOR G LEVEL 7 LYMPH NODE OPERATION: PNEUMONECTOMY Page 2 of 5 Printed by: (Continued) Printed on:
+
+--- Page 3 ---
+PRE-OP DIAGNOSIS: MESOTHELIOMA POST-OP DIAGNOSIS: SAME CLINICAL DATA: NOT GIVEN GROSS DESCRIPTION: that measures 30.0 x 23.8 x 8.0 cm, overall. The specimen includes the entire left lung and has an attached portion of diaphragm and pericardium. The pericardium is 12.0 x :l.5 cm and has a gray-pink, smooth, glistening surface. The diaphragm is 23.0 x 14.5 x 2.0 cm. The surgical resection margin surrounding the diaphragm and pericardium are inked black. The bronchial margin and vessel margin at the hilum, are taken and upon opening of both the bronchi and vessels, all are unremarkable. Eight (8) hilar lymph nodes are identified, ranging from 0.9 x 0.7 x 0.4 cm up to i.4 x 1.2 x'0.5 cm. Upon. dissection, some of the larger lymph nodes have a dark-black to gray, smooth, glistening cut surface.  The parietal pleura is red-pink, smooth and upon. palpation is indurated in some areas. The specimen is bivalved to reveal a gray-white, firm rim of tumor,  extending into the lung parenchyma and involving ranges from 0.6 cm up to 8.5 cm in thickness..  The interlobar fissure is involved and obliterated. The inferior aspect of the Iung is remarkable for a 1.5 cm cavity, containing a clear fluid and is lined by dusky, soft, necrotic material. The uninvolved diaphragm is red and soft. The uninvolved lung parenchyma is red, soft and spongy. Representative sections are submitted in 32 cassettes. Section summary: 1-2 tumor with diaphragm 3- tumor with pericardium 4- tumor with pleura 5- bronchial margin. 6- artery margin 7- vein margin. 3-12 tumor with pericardium (#12 includes diaphragm) 13-17 tumor with diaphragm (#15 includes visceral pleura; 16-17 include cavity) 18- tumor with parietal pleura 19-20 tumor with intralobar fissure 22-24 tumor with lung parenchyma (#22 includes hilar nodes). 25- two lymph nodes 26- two lymph nodes. 27- half of one bisected lymph node 28- other balf of one bisacted lymph node 29-31- one bisected lymph node, each 32- viscera, parietal pleura with tumor and lung parenchyma.. NOTE: Additional sections consisting of the tumor with pleural surface is submitted in cassettes add 1-5. B. Received fresh, labeled level 10 lymph node, is a 1.7 x 1.4 x 0.3 cm red-pink, sott lymph node, which has a scant amount of attached soft tissue. Printed by: Page 3 of 5 Printed on: (Continued)
+
+--- Page 4 ---
+wThe specimen is bisected to reveal a dark-red, congested cut surface. The lymph node is entirely submitted in 1 cassette.. C. Received fresh, labeled mediastinal fat, is a 4.3 x 3.5 x 1.0 cm soft, lobulated portion of adipose tissue. Dissection reveals six (6) possible lymph nodes, ranging from 0.4 cm up to 1.0 x 0.6 x 0.4 cm. Two (2) of the lymph nodes are sectioned to raveal purple-pink, smooth and glistening cut surfaces. Lymph nodes are. entirely submitted in 3 cassettes labeled C, as follows: 1- one bisected lymph node. 2- two possible lymph node. 3- three lymph nodes. D. Received fresh, labeled bronchial margin, is a pink-yellow, rubbery tubular structure, consistent with portion of bronchus which is 2.l cm in length and 1.7 cm in diameter. Along one aspect, is a staple line which is 3.0 cm in length. The specimen is trisected and submitted entirely in 3 cassettes labeled D (region adjacent to staples is in cassette #1).. E. Received fresh, labeled thoracoscopy site #1, posterior, is a 7.5 x 2.0 cm tan ellipse of hair-bearing skin, that is excised to a depth ranging from 1.5 The deep margin consists of possible brown-red, skeletal. cm up to'3.0 cm. muscle that is 2.8 x 1.6 x 1.5 cm. The surgical resection margin is inked. black.  The specimen is serially sectioned to reveal lobulated adipose tissue with interspersed gray, fibrous tissue and skeletal muscle at the deep margin. No lesions are identified, grossly. Representative sections submitted in three cassettes labeled E (one full thickness section cut in half in cassette #1-2). F. Received fresh, labeled thoracoscopy site #2, anterior, is a 4.3 x 1.7 cm The brown ellipse of hair-bearing skin, that is excised to a depth of 2.3 cm. skin surface is remarkable for a 1.6 cm possible well-healed scar. The.  The specimen is serially sectioned surgical resection margin is inked black.. to reveal yellow, lobulated, soft cut surfaces with interspersed gray, fibrous tissue.  Representative sections submitted in three cassettes labeled r. G. Received fresh, labeled level 7 lymph node, are four (4) gray-black, soft, irregular lymph nodes, ranging from i.4 x 1.3 x 0.5 cm up to 4.0 x 2.0 x 0.7 cm. The lymph nodes are bisected to reveal dark-black, gray, mottled, smooth and glistening cut surfaces. The smaller lymph nodes are entirely submitted and reps of larger lymph node submitted in 5 cassettes labeled G, as follows: 1-3 one bisected lymph node, each 4-5 reps of largest lymph node.. CPT CODE: ELECTRONIC SIGNATURE: Page 4 of 5 Printed by: (Continued) Printed on...
+
+--- Page 5 ---
+Completed Action List: * Perform by Printed by: Page 5 of 5 Printed.on: (End'of Report)
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index 0000000000000000000000000000000000000000..31f0ab8d76c7161a9a35e854fd83e09ce9de2c0e
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+
+--- Page 1 ---
+3d4/ Ics-0-3 Caucnorns, iifiltnstny duct, Nos 85o0/3 S1te' brast, Nos C50.9 DIAGNOSIS (A) LEFT AXILLARY SENTINEL LYMPH NODE #1, EXCISION: METASTATIC CARCINOMA INVOVLiNG 1 OF 1 LYMPH NODE (1/1). LYMPH NODE METASTASIS MEASURES 0.2 MM AND IS SEEN ON H AND E SECTION.  NO EXTRA NODAL EXTENSION IDENTIFIED. (B) LEFT AXILLARY SENTINEL LYMPH NODE #2, EXCISION: One lymph node, no tumor present. (C) LEFT AXILLARY SENTINEL LYMPH NODE #3, EXCISION: One lymph node, no tumor present. (D) LEFT AXILLARY SENTINEL LYMPH NODE #4, EXCISION: One lymph node, no tumor present. (E) LEFT AXILLARY SENTINEL LYMPH NODE #5, EXCISION: Two lymph nodes, no tumor present. (F) LEFT AXILLARY SENTINEL LYMPH NODE #6, EXCISION: One lymph node, no tumor present. (GY LEFT BREAST, TOTAL MASTECTOMY: INVASIVE DUCTAL CARCINOMA, MODIFIED BLACK'S NUCLEAR GRADE 3 (POORLY DIFFERENTIATED) INVOLVING TWO SEPARATE NODULES. (SEE COMMENT) INVASIVE DUCTAL CARCINOMA MEASURES 1.8 CM AND 0.5 CM IN GREATEST DIMENSION. DUCTAL CARCINOMA IN SITU (INTERMEDIATE GRADE) CRIBRIFORM AND SOLID PATTERNS, INVOLVING LESS THAN 5% OF THE TUMOR. LYMPHOVASCULAR iNVASION IDENTIFIED. Pseudo angiomatous stromal hyperplasia.. Columnar cell alterations. Proliferative tibrocystic changes. Fibroadenoma. Margins of resection are free of tumor. (H) LEFT AXILLARY SENTINEL LYMPH NODE #7, EXCISION: One lymph node, no tumor present. (I) SENTINEL LYMPH NODE #8, EXCISION: UUID:D437E9FF-5C09-4FD6-BB0B-0881CD4C50D7 TCGA-GM-A2DI-01A-PR One lymph node, no tumor present. Redacted Entire report and diagnosis completed by COMMENT Invasive ductal carcinoma is present in two different foci, the larger nodule measures 1.8 cm in greatest dimension and is located in the left upper outer quadrant at 3-4 o'clock. The smaller nodule measures 0.5 cm in greatest dimension and is located in the lower inner quadrant. Resection margins are negative for tumor.. Prognostic markers were performed on the patient's core biopsy. ROSS DESCRIPTION (A) LT AXILLARY SLN #1, BLUE, COUNT IN VIVO 320, EX VIVO 543 - A tan-blue stained lymph node (1.2 x 0.7 x 0.6 cm) Trisected. Touch preparations are made.. *FS/DX: NEGATIVE FOR TUMOR. (B) LT AXILLARY SLN #2, BLUE, COUNT iN VIVO 53, EX VlVO 33 - A tan-blue stained lymph node (1.2 x 0.7 x 0.6 cm). Trisected. Touch preparations are made. Submitted for touch prep analysis ( 2 touch preps). *FS/DX: NEGATIVE FOR TUMOR. ) LT AXILLARY SLN #3, BLUE, COUNT IN VIVO 300, EX VIVO 588 - A tan-blue stained lymph node (0.9 x 0.6 x 0.5 cm). Trisected. Touch preparations are made. Submitted for touch prep analysis ( 2 touch preps)
+
+--- Page 2 ---
+(D) LT AXILLARY SLN #4, IN VIVO 300, EX VIVO 44 - A tan-blue stained lymph node (0.5 x 0.2 x 0.2 cm). Touch preparations are made. Bisected and Submitted tor touch prep analysis (2 touch preps)... *FS/DX: NEGATIVE FOR TUMOR. (E) LT AXILLARY SLN #5, BLUE, COUNT IN VlVO 107, EX VlVO 212 - Two tan-blue stained lymph nodes (1.2 x 0.5 x 0.5 cm and 0.6 x 0.4 x 0.4 cm). Touch preparations are made. Larger node is sectioned into tive pieces and entirely submitted in E1. Smaller lymph node is bisected and submitted in toto in E2.. *FS/DX: NEGATIVE fOR TUMOR. (F) LT AXILLARY SLN #6, BLUE, COUNT IN VIVO 44, EX VIVO 92 - A tan-blue stained lymph node (0.9 x 0.8 x 0.8 cm). Touch preparations are made. Trisected and Submitted for touch prep analysis ( 2 touch preps).e *FS/DX: NEGATIVE fOR TUMOR. (G) LEFT BREAST - An oriented mastectomy specimen (15.0 x 11.0 x 4.0 cm), with skin ellipse (14.5 x 7.5 x 0.2 cm). Unremarkable areola and nipple (0.9 x 0.9 cm). Seriatly sectioned from lateral to medial. A tan tirm mass (index mass) with irregular borders located in left outer quadrant, at 3-4 o'clock, 1.8 x 1.7 x 1.5 cm.. Closest margin is deep margin. Diffuse areas of nodularity and tibrosis adjacent to the tumor and extending superiorly into the upper outer quadrants and into the inner quadrants, measuring 6.0 x 5.0 x 5.0 cm. A white fibrotic nodule, located in lower outer quadrant, at 5 o'clock, 2.3 x 1.5 x 1.5 cm. A tirm white tibroadenoma, 1.0 x 1.0 x 0.9 cm is located at 12 o'clock. NOTE: The specimen is inked different from routine.. INK CODE: Blue - superior, black - deep, green - interior, red - medial and lateral.. SECTION CODE: G1, index mass and deep margin; G2-G5, index mass; G6, G7, tibrotic nodule at 5 o'clock; G8, G9, possible tibroadenoma at 12 o'clock; G10, G11, upper outer quadrant; G12-G14, lower inner quadrant; G15, upper inner quadrant; G16, lower inner quadrant; G17, deep margin; G18, superior margin; G19, interior margin; G20, nipple; G21, skin.. (H) LEFT AXILLARY SENTINEL LYMPH NODE #7 IN VlVO 35, EX ViVO 55- One lymph node, 0.2 x 0.2 x 0.1 cm. Two touch preps are performed and the specimen is entirely submitted for frozen section per protoco! H. . *TP/DX: NO TUmOR PRESenT. (l) SENT!NEL LYMPH NODE #8, NOT BLUE, iN VlVO 55. EX VIVO 85 - A 0.3 x 0.2 x 0.2 cm pink-tan lymph node, bisected and submitted in toto in I. Two touch preps prepared *TP/DX: NO TUMOR PRESENT. CLINICAL HISTORY Breast carcinoma. SNOMED CODES T-04050, M-85003, M-80310, M-72571 "Some tests reported here may have been developed and performance characteristics determined by i These tests have not been specifically cleared or approved by the U.S. Food and Drug Administration." Released by: ---END OF REPORT--
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diff --git a/output/text/881ca3fc-0a97-4ea1-9a7e-b8012f75273e.txt b/output/text/881ca3fc-0a97-4ea1-9a7e-b8012f75273e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8c1967dbd79e33e32af8dfa3f7fd77dba29d016e
--- /dev/null
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+Tss: SPECIMENS: A. WIDE LOCAL EXCISION LEFT BREAST B. SENTINEL LYMPH NODE #1 LEFT AXILLA 1cs-0-3 C. SENTINEL LYMPH NODE #2 LEFT AXILLA D. SENTINEL LYMPH NODE #3 LEFT AXILLA Caucin oma, ifn1trstixg 1obule, N0S E. SENTINEL LYMPH NODE #4 LEFT AXILLA F. SENTINEL LYMPH NODE #5 LEFT AXILLA 8520/3 Sit: brust nos c50.9 SPECIMEN(S): A. WIDE LOCAL EXCISION LEFT BREAST 8/34f B. SENTINEL LYMPH NODE #1 LEFT AXILLA C. SENTINEL LYMPH NODE #2 LEFT AXILLA D. SENTINEL LYMPH NODE #3 LEFT AXILLA E. SENTINEL LYMPH NODE #4 LEFT AXILLA F. SENTINEL LYMPH NODE #5 LEFT AXILLA DIAGNOSIS: A. BREAST, LEFT, WIDE LOCAL EXCISION: - MULTIFOCAL INVASIVE LOBULAR CARCINOMA, NOTTINGHAM GRADE 2. - LARGEST FOCUS IS 3.5 CM. - INVASIVE CARCINOMA IS PRESENT AT THE SUPERIOR MARGIN AND IS WITHIN 0.1 CM OF THE INFERIOR MARGIN. - LOBULAR CARCINOMA IN SITU (LCIS). NOTE: Several foci of invasive carcinoma are seen, spanning throughout a 6.4 cm lumpectomy. B. SENTINEL LYMPH NODE 1, LEFT AXILLA, BIOPSY: - METASTATIC CARCINOMA (1.9 CM IN SIZE) IN ONE LYMPH NODE WITH FOCAL EXTRANODAL EXTENSION (1/1). C. SENTINEL LYMPH NODE 2, LEFT AXILLA, BIOPSY:  - ONE LYMPH NODE, NEGATIVE FOR CARCINOMA (0/1). D. SENTINEL LYMPH NODE 3, LEFT AXILLA, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR CARCINOMA (0/1). E. SENTINEL LYMPH NODE 4, LEFT AXILLA, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR CARCINOMA (0/1). F. SENTINEL LYMPH NODE 5, LEFT AXILLA, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR CARCINOMA (0/1). SYNOPTIC REPORT - BREAST Specimen Type: Excision Needle Localization: No Laterality:  Left Invasive Tumor: Present Multifocality: Yes UUID:E6A21CE6-841D-4D98-A563-8089BAF6E682 WHO CLASSIFICATION TCGA-E2-A2P6-01A-PR Redacted Invasive lobular carcinoma 8520/3 Tumor size: 3.5cm Tumor Site: Upper outer quadrant. Margins:  Involved at superior Extent:: 0.2 cm Tubular Score: 3 Nuclear Grade: 2 Mitotic Score: 1 Modified Scarff Bloom Richardson Grade: 2 Necrosis:  Absent Vascular/Lymphatic Invasion:  None identified
+
+--- Page 2 ---
+TSS: Lobular neoplasia: LCIS Lymph nodes:  Sentinel lymph node Lymph node status:  Positive 1 / 5 Extranodal extension  Non-neoplastic areas: columnar cell change DCIS not present ER/PR/HER2 Results ER: Positive PR: Positive HER2: Negative by FISH Performed on Case: Pathological staging (pTN): pT 2 N 1 Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition GROSS DESCRIPTION:E A. WIDE LOCAL EXCISION LEFT BREAST Received fresh labeied with the patient's identification and designated *left breast wide local excision" is. an oriented, previously inked, 55 g, 6.4 x 5.5 x 3.3 cm lumpectomy. The single suture designates anterior, double-lateral, triple-superior. Ink code: Anterior-yellow, posterior-green, medial-black, lateral- red, superior-blue, inferior-orange. The specimen is serially sectioned from posterior to anterior into 5 slices revealing a 2.5 x 2.1 x 1.9 cm, ill-defined firm pale tan mass, located 0.6 cm from the latera! margin. The remainder of the specimen shows focal areas of white dense fibrous parenchyma. Tissue is procured. The specimen is representatively submitted: A1-A2: Representative section posterior margin (green ink) A3: Slice 2, inferior/lateral. A4-A5: Slice 2, lateral/medial, respectively A6-A11: Slice 3, entirely submitted, A7 demonstrating mass and nearest the lateral margin. A12-A13: Slice 4, mass, lateral margin A14-A15: Slice 4, medial/inferior, respectively A16: Slice 4, superior A17-A18: Representative perpendicular sections anterior margin B. SENTINEL LYMPH NODE #1 LEFT AXILLA Received fresh labeled with the patient's identification and designated *sentinel lymph node #1 ieft axilla" is a yellow-tan lymph node measuring 1.9 x 1.7 x 1.5 cm. The specimen is sectioned, entirely submitted, B1. C. SENTINEL LYMPH NODE #2 LEFT AXILLA Received fresh labeled with the patient's identification and designated "sentinel lymph node #2 left axilla" is a yellow-tan lymph node measuring 2.4 x 0.8 x 0.4 cm. The specimen is sectioned, entirely submitted, C1. D. SENTINEL LYMPH NODE #3 LEFT AXILLA Received fresh labeled with the patient's identification and designated *sentinel lymph node #3 left axilla" is a tan lymph node measuring 1.6 x 1 x 0.5 cm. The specimen is sectioned, entirely submitted. D1. E. SENTINEL LYMPH NODE #4 LEFT AXILLA Received fresh labeled with the patient's identification and designated "sentinel lymph node #4 ieft axilla" is a yellow-tan lymph node measuring 1.5 x 1.1 x 0.3 cm. The specimen is sectioned, entirely submitted, E1. F. SENTINEL LYMPH NODE #5 LEFT AXILLA Received fresh labeled with the patient's identification and designated "sentinel lymph node #5 left axilla" is a tan lymph node measuring 0.8 x 0.5 x 0.2 cm. Entirely submitted, F1.. CLINICAL HISTORY: 1.5-2 cm invasive cancer upper outer quadrant left breast PRE-OPERATIVE DIAGNOSIS: Left breast cancer FROZEN SECTION INTRAOPERATIVE REPORT: Part A: Breast, left, wide local excision, gross examination: 2.4 cm tumor mass located approximately 0.6 cm to the lateral margin, gross examination only.
+
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+TSS: Diagnosis called at. by Dr. Gross Dictation... .. Microscopic/Diagnostic Dictation: Patnoiogist, Final Review: Pathologist, Final: Pathologist,.
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diff --git a/output/text/8824134b-8b4a-407b-adab-297330b4de4e.txt b/output/text/8824134b-8b4a-407b-adab-297330b4de4e.txt
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index 0000000000000000000000000000000000000000..5597b86fc0a03210502754f63349b916e0ef1f6b
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+mflf^atuvy suctsl, N0s 85oo/3 c50.9 Site Codi. breaot Nus J7/ Surgica Surg Path UUID:6C50D456-A828-4S14-92D2-01A5900074F1 TCGA-B6-A0RL-01A-PR Redacted CLINICAL HISTORY: Left breast mass, positive biopsy. Rule out breast CA. GROSS EXAMINATION: A. "Left breast biopsy", in formalin. Received is a portion of adipose. tissue which measures 4.5 x 4.0 x 1.9 cm in greatest dimensions. A firm nodule is felt within the adipose tissue. Sections through this nodule reveal greatest dimensions. The tumor approaches the margin of resection. Frozen section was done on this tumor. Initially, the tissue is submitted for ER/PR receptors.  The frozen section remnant is submitted in Block Al. Additional representative sections of tumor are submitted in Blocks A2 and A3. B. "Left breast with axillary contents". Received is a 620 gram, 20 x 16 x 3.5 cm modified radical mastectomy with attached axillary tail. The attached axillary tail measures 8 cm x 7.5 cm x 1.8 cm. The skin ellipse measures 20 cm in length x 7.5 cm in width with a medially eccentrically placed nipple. Lateral and inferior to the nipple is a 5 cm sutured incision. The deep. surface is painted with blue ink. Deep to the incision there is a hemorrhagic biopsy cavity which measures approximately 5 cm x 4.5 cm x 3 cm in greatest dimensions.  The biopsy cavity approaches the deep margin of the specimen, but. no residual tumor is identified. Along the superficial edge of the biopsy cavity is a residual firm nodule which measures 1.5 x 2.0 x 0.8 cm is felt. Examination of the remainder of the breast reveals only firm, white breast tissue and adipose tissue. The axillary tail is examined for lymph node candidates. Block Summary: B1: Representative sections of nipple.. B2: Representative sections of skin through incision. B3-B5: Representative sections of biopsy cavity to include deep margins. b6,b7: Nodule along superior aspect of biopsy cavity. B8: Representative section of upper inner quadrant. b9: Representative sections of lower inner quadrant. B10: Representative section of upper outer quadrant. B11: Representative section of normal lower outer quadrant. B12,B13: Lymph node candidates from Level-I. B14-B16: Lymph node candidates from Level-II (a single large lymph node candidate is bisected and submitted in toto in Block A16). B17,B18: Lymph node candidates from Level-III. INTRA OPERATIVE CONSULTATION:S "Left breast biopsy": AFl - Carcinoma. DIAGNOSIS: A. "LEFT BREAST BIOPSY": INFILTRATING DUCTAL CARCINOMA (3 CM DIAMETER), NSABP NUCLEAR GRADE 3 Of 3) HISTOLOGIC" GRADE III. A SPINDLE CELL COMPONENT IS PRESENT. FOCAL INTRADUCTAL CARCINOMA OF COMEDO TYPE. B. "LEFT BREAST WITH AXILLARY CONTENTS": INFILTRATING DUCTAL ADENOCARCINOMA, NSABP NUCLEAR GRADE 2 tO 3; HISTOLOGIC GRADE II. 1 of 2
+
+--- Page 2 ---
+SURGICAL MARGINS ARE FREE OF MALIGNANCY. ZERO OF 16 LYMPH NODES ARE POSITIVE FOR METASTATIC DISEASE. Verified by 2 of 2
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diff --git a/output/text/8832b5ee-4e04-4a10-bc10-432baff742c6.txt b/output/text/8832b5ee-4e04-4a10-bc10-432baff742c6.txt
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index 0000000000000000000000000000000000000000..814edcc46187a1986c68060bc938da90efa9855f
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+UUID:C49E8289-A19F-43FC-9A77-1888843F53100 TCGA-AC-A5EH-01A-PR Redacted Patient Referring Physician:. Gender:F Hosn# Drawider (Grnun Date of Service: A copy of this report will be faxed to:. FINAL SURGICAL PATHOLOGY REPORT Diagnosis: S Left breast, moDifIed radical mastecTomy: - Two foci of invasive ductal carcinoma, Nottingham grade 2 (see comment). - Size: 2.3 cm and 0.7 cm.. TeD - Location: lower outer (4:00) and inner (7:00) quadrants, respectively.. CACF - Associated ductal carcinoma in situ (DciS), intermediate nuclear. C grade, cribriform and micropapillary patterns with punctate necrosis. and without calcifications.. -3 - Size: DCIS spans a region measuring approximately 3.8 cm and. comprises 10% of tumor. Wuost, - Margins of resection are widely free of invasive and in situ tumor (at least 1.2 cm. away). - Focus suspicious for lymphovascular invasion identified. - Micrometastatic carcinoma (1.7 mm) identified in one of fourteen axillary LOQ Iymph nodes (1/14); no extranodal extension identified. - Prior biopsy site changes present.. - Uninvolved breast parenchyma with fibrocystic changes and vascular. calcifications. - Benign skin and nipple.. 50. 50 850c/3 COMmENT: The two foci of invasive ductal carcinoma are similar histologically.. Although there was little tubule formation identified on prior needle biopsy of the 7:00 lesion, tubule formation is more apparent on excision (>10%). Thus, the overall. Jo 1/21 histologic grade is Nottingham grade 2 for both lesions.. PATHOLOGIC TUMOR STAGING SYNOPSIS: Type and grade (invasive): Invasive ductal carcinoma, Nottingham grade 2.. W Type and grade (in situ): DCis, intermediate nuclear grade. Primary tumor: pT2(m). Regional Iymph nodes: pN1(mi) Distant metastasis: N/A. Case # Page 1 Printed: This report continues... (FINAL) MR NO. Pathology - Page 1/5
+
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+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT Stage: IIB. Lymphovascular invasion: Not identified. Margin status: Ro, negative.. Invasive Breast Cancer Tumor Staging Information AJCC Cancer Staging Handbook, 7th Ed., and CAP Protocol (revised Previous pathology specirmens. Case # Page 2 Printed: This report continues... (FINAL). Pathology - Page 2/5 ) - Page 2 Doc#1
+
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+Patient: Case # SPECIMEN IDENTIFICATION Procedure/specimen type: Moditied radical mastectomy. Laterality: Left breast. Lymph node sampling: Axillary dissection. INVASIVE CARCINOMA TUMOR CHARACTERISTICS Histologic type: Invasive ductal carcinoma. Tumor site: Lower outer (4:00) and inner (7:00) quadrants. Tumor size: 2.3 cm and 0.7 cm. Tumor focality: Multifocal (two foci). Mistologic grade (Nottingham Score): 2 of 3 (Nottingham score 6 -7 of 9) Tubule formation: 2 0f 3. Nuclear pleomorphism: 2-3 of 3. Mitotic rate: 2 of 3. Lymphovascular invasion: Focus suspicious for lymphovascular invasion identified. Macroscopic and microscopic extent of tumor:. Benign skin and nipple. DUCTAL CARCINOMA IN SITU (DCIS): Associated DciS, internediate nuclear grade,. cribriform and micropapillary patterns, comprising 10% of tumor and spanning about. 3.8 cm. MARGINS Invasive carcinoma: Widely negative for tumor (at least 1.2 cm away).. Ductal carcinoma in situ: Widely negative for tumor (at least 1.2 cm away). LYMPH NODES Total lymph nodes examined 14. Number of lymph nodes involved 1 (micrometastasis). Size of largest metastatic deposit: 1.7 mm. Extranodal extension: Absent. PATHOLOGIC STAGING: Primary Tumor (pT): pT2(m). Regional lymph nodes (pN): pN1(mi). Distant mmetastasis (pM): N/A. AJCC Stage: 118. ANCILLARY STUDIES: ProPath Estrogen receptor: POSITIVE (80-85% positive cells, moderate-strong intensity) (4:00). Progesterone receptor: Negative (0% positive cells) (4:00) MER2: Negative (score 0) (4:00) Page 3 This report continues.. (FINAL) Pathology - Page 3/5 J- Page 3 Doc# 1
+
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+Patient Case # FINAL SURGICAL PATHOLOGY REPORT Ki-67: Migh (40% positive cells) (4:00). Estrogen receptor: POSITIVE (20% positive cells, moderate-strong intensity) (7:00). Progesterone receptor: Negative (0% positive cells) (7:00) HEr2: Negative (score 0) (7:00). Ki-67: High (65% positive cells) (7:00). Source of Specimen: Breast;left breast radical mastectomy Clinical History/Operative Dx: Breast cancer Gross Description: Single specimen designated left breast radical mastectomy. Initially received in a fresh state for Oncogenotyping tissue harvest is a left modified radical mastectomy weighing 809 grams, and measuring 20.8 x 17.3 x 5.8 cm (not including axillary extension), and the axillary wing extending 10.5 x 9.0 x 4.0 cm. The overlying ellipse of tan-brown skin is 22.8 x 11.3 cm, with a paracentral darken brown, wrinkled areola, 3.2 cm in diameter and a flattened 1.1 cm nipple. A palpable mass is appreciated in the lower outer quadrant. A suture marks the medial apex of the specimen. The surgical margins are now differentially inked as follows: Superior-superficial is marked blue, Inferior-superficial is marked orange, Deep is marked black. The breast is serially sectioned perpendicularly through the medial-lateral long axis, to reveal a partially. circumscribed. dense pink-gray, tumor mass measuring upwards of 2.3 x 1.5 x 1.3 cm (slabs 4-6, from. Iateral). This mass is placed in the lower outer quadrant, approximating the 4:00 position and grossly approaching within 1.8 cm of the deep, 2.3 cm of the inferior superficial, 5.0 cm of the lateral extension of breast (not including axillary) and greater than 12.0 cm from the most medial extension of breast. The Case# Page 4 This report continues... (FiNAl) Acct No. Patient Na Pathology - Page 4/3 Page 4 Doc# 1
+
+--- Page 5 ---
+Patient: Case #: FiNAL SUrgiCAL PAthOLOgy rEPORt tumor includes an embedded hook-shaped metallic clip. Representative portion of the tumor, peri-neoplastic. and normal breast parenchyma is submitted for Oncogenotyping studies. A second, discrete, poorly visualized glistening tan lesion, is within the lower inner quadrant, approximating the 7:00 position, and measuring up to 0.7 x 0.5 x 0.5 cm and placed within 2.3 cm of the inferior superficial, 2.4 cm of the deep, and greater than 5.0 cm from the most medial extension of breast. A second biopsy site clip is not appreciated.  The cut sections of the remainder of the breast demonstrate prominent ductal tracts in the subareolar Iesion, up to 0.5 cm in diameter, exuding yellow-gray cheesy material, and bluish purulent fluid. Several. blue dome cysts are up to 0.6 cm. Initial examination of the axillary extension of fat reveals fifteen lymph node candidates, ranging from 0.2. cm - 2.0 x 1.7 x 1.2 cm in greatest dimension. The lymph node lissue is represented for microscopic evaluation. Cassette summary: A1) nipple, subareolar tissue, two pieces, A2) medial and lateral extension of skin, A3-A5) large tumor mass, Jower outer quadrant, represented, A6) deep margin adjacent to large tumor mass, A7) inferior superficial margin adjacent to large tumor mass, A8-A10) lateral extension of breast tissue, adjacent to large mass, slabs 3, 2, 1, respectively. A11) breast tissue medial to large tumor, slab 7.. A12-A14) second nodular lesion and inferior superficial margin and deep margin (A14),. A15) central breast-subareolar. A16) upper outer quadrant, slab 3, A17) upper inner quadrant, second slab from medial,. A18) four small lymph node candidates, A19) three lymph node candidates, most proximal to breast,. A20) four lynph node candidates, A21) single lymph node candidate bisected, A22) single lymph node candidate trisected, A23) enlarged flattened lymph node bisected, A24) largest lymph node candidate serially sectioned and submitted. Microscopic Description: Microscopic sections have been examined. The nicroscopic findings are reflected in the diagnosis. rendered. Intradepartmental consultation: has reviewed selected slides and concurs. Case # Page 5 FNDOFRFPORT FINAI) lw12/21/1 Acct No. - Patient Name Pathology - Page 5/5 crepancy Jolt Prior Malignancy Histony
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diff --git a/output/text/8867b595-f7f0-422d-844d-807b01196ea8.txt b/output/text/8867b595-f7f0-422d-844d-807b01196ea8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..36e914629c716f49014afba4981921c87327dffe
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+--- Page 1 ---
+DIAGNOSIS DIAGNOSIS: Kidney, right, radical nephrectomy:. "Renal cell carcinoma, papillary type (type il), grade 3 (Fuhrman), 2 cm in greatest dknension involving the lower pole, confined to the kkiney,. and without invasion of perirenal fat or renal sinus fat. Ureter, renal artery, and renal vein at surgical margin negative for malignancy. Negative for Iymphatic space invasion. Non-neoplastic renal parenchyma shows mild arterionephrosclerosis. No lymph nodes or adrenal gland present. AJCC cancer dlassification: T1aNxMX. AF .RANSLSKSCLNICALINFORMATION.. CLINICAL HISTORY: Preoperative Dlagnosis: Postoperative Diagnosis: Symptoms/Radiologic Findings: SPECIMENS: Right kidney : SPECIMEN.DATA GROSS DESCRIPTION: The specimen is received in a single fornatin filled container labeled with the patient's name. right kidney' and consists of a right nephrectomy specamen with attached Gerota's fascia and perinephric fat having overail dimensions of 17.0 x 8.5 x 6.5 cn. Extending from the hilum is a 4.0 cm in length by 0.4 cm in diameter segment of ureter with adjacent segnents of vascylature. The specimen is inked. The capsule strips with ease to reveal an 8.5 x 6.0 x 4.5 cm kidney. The kidney is bivalved to reveal a 2.0 x 1.9 x 1.9 cm yellow tan hemorrhagic, variegated mass arising. from the lower pole. This mass approaches to within 3.5 cm of the ureteral margin, 2.0 an of the renal vein margin and 1.0 cm of the inked soft tissue. margin. Additionally, this mass abuts, but does not grossly invoive the urothehium..  The calices and renal petvis are lined by pink tan striated urothelium with no additional lesions. The cortex is red brown with distinct cortical medullary junction and non-blunted renal papilla. No adtenal giand or ailar lymph nodes are identified. Representative sections are submitted in five cassettes labeled  designated as follows: 1-ureteral and. vasculature margins, en-face; 2-mked soft tissue margin, perpendkular; 3-mass to renal parenchyma and sinus fat;. emaind'or of mass: 5 uninvolved parenchyma. Additionally, a yellow and green cassette are submitted for genomic research each labeled. An additional section vein suhmtted in cassette 6 labeled.
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index 0000000000000000000000000000000000000000..655de23e9a30fc9580575b88fa430f873a71c5c1
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+page 1 / 2 Department of Cancer Pathology copy No. Date: Examination: Histopathological examination Internal invoice No. Cost of diagnostic procedure Examination No.: Patient: XXX PEseL: XXX Age: Gender: F Jcd-0 -3  Material: Multiple organ resection -- right breast;and axillary tissues CarCinomn,hfi{tnstmy duct,nos 85vsf3 Unit in charge: Central Operating Theatre Sin;bvsot,nos C5o.9 p~ 4/1H11 Physician in charge: ref. No. Material collected on: Material received on: Expected time of examination: up to 8 working days Clinical diagnosis: Examination performed on: Macroscopic description: Right breast'sized 21 x 15 x 3.5 cm, removed with axillary tissues sized 8 x 8.5 x 3 cm and a skin flap of 21 x 12 cm. Tumour sized. 1.2 x 1.1 x 0.8 found in the lower outer quadrant, located 3.5 cm from the upper boundary, 2 cm from the base and 0.6 cm from the skin. Microscopic description: Carcinoma ductale invasivum - NHG3 93 + 2 +3: 21 mitoses/10 HPF - visual area 0.55 mm). Glandular tissue, apart of the tumour, showing lesions of the type mastopathia fibrosa et cystica, lipomatosis.. AXILLARY LYMPH NODES Metastases carcinomatosae in lymphonodis (No V1/xiv).  Infiltratio capsulae lymphonodorum. Histopathological diagnosis: Carcinoma ductale invasivum mammae dextrae. Metastases carcinomatosae in lymphonodis axillae (NO vi/xiv). (NHG3, pTlc, pN2a). Invasive ductal carcinoma of the'right breast: Cancer metastases of the axillary lymph nodes (No Vi/xiv)..  UUID:106EE39C-DE75-4595-943A-CF53873F96BF TCGA-D8-A1XZ-01A-PR Redacted
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+page 2 / 2 Compliance validated by: Examination performed or. Results of immunohistochemical examination: Estrogen receptors found in over 75% of neoplastic cell nuclei. No progesterone receptors found in neoplastic cell nuclei. HER2 protein stained with HercepTestTM by DAKO. Negative reaction in invasive cancerous cells ( Score = 1+ ) C'ompliance validated by: CONTACT YOUR DOCTOR WITH THIS REPORT!
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diff --git a/output/text/88822fb8-e39f-4230-ba9a-da3be1ded97c.txt b/output/text/88822fb8-e39f-4230-ba9a-da3be1ded97c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6cdafec8850eb0455d2fbc2b38c7718b34b57139
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+SURGICAL PATHOLOGY REPORT SPECIMEN A. Descending colon B. Liver biopsy CLINICAL NOTES PRE-Op DiAgnosis: Descending colon cancer. GROSS DESCRIPTION A.  Received fresh, subsequently fixed in formalin labeled "descending colon" is a 21 cm long portion of colon which has a. portion of omentum attached. The omentum is 25 x 13 x 4 cm.. The omentum is sectioned and palpated to show no discrete gross lesions identified. The ends of the specimen are opened and are arbitrarily inked blue and black.  No orientation of the specimen is given. The spe cimen  is partially covered with pink-tan smooth glistening serosa and abundant yellow lobular fat. The specimen shows a 2.7 x 2.7 cm exophytic tumor which is equidistance between either end (5.7 cm). The specimen shows otherwise pink-tan smooth glistening mucosa with normal to abundant folds having an average circumference of 6.5 cm. The cut surface of the tumor shows possible invasion into the. muscularis propria, coming within 2 cm of the deep margin. Lymph nodes are grossly identified in the fat. Representative sections of representative luminal margins; block 2 - representative section of omentum; blocks 3,4  - full thickness slices of tumor to radial margin tumor to normal; blocks 6-9 - possible lymph nodes. B. Received fresh, subsequently fixed in formalin labeled "liver biopsy" are multiple red-brown irregular to cylindrical tissue fragments which have an aggregate measurement of. 1.2 x 0.4 ecimens are entirely submitted in one cassette. MICROSCOPIC DESCRIPTION A&B: Histologic type: Invasive adenocarcinoma, not otherwise specified. Histologic grade: Moderately differentiated. Primary tumor (pT): Tumor invades through muscularis propria in two pericolonic fat (pT3). Proximal margin: Negative for tumor. Distal margin:  Negative for tumor. Circumferential (radial) margin: Negative for tumor. Distance of tumor from closest margin: 5.7 cm from both proximal and distal margin. Vascular invasion: Not identified. Regional lymph nodes (pN): 21 lymph nodes are all negative for. metastatic tumor (pN0). Non-lymph node pericolonic tumor: Not identified. Distant metastasis (pM): Metastatic carcinoma is identified in the liver core biopsy in specimen B (pml). Other findings: The attached omentum is negative for tumor. The background colonic mucosa was unremarkable. The background hepatic
+
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+parenchyma was fairly unremarkable other than reactive changes to the tumor and some mild steatosis. 5x1, 4x1 DIAGNOSIS A. Colon, descending, segmental resection: Invasive moderately differentiated adenocarcinoma, tumor. invades through muscularis propria into pericolonic fat (pT3). Twenty one lymph nodes negative for metastatic tumor (pn0). Resection margins are negative for tumor. Omentum is negative for tumor. core biopsies: Metastatic adenocarcinoma compatible with origin from colonic primary.  End Of Report
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diff --git a/output/text/8890d2ff-a370-4771-9e7c-ee5bd328fbbe.txt b/output/text/8890d2ff-a370-4771-9e7c-ee5bd328fbbe.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c8e281cd9d4ed89d610bab61946043fc40f5a209
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+UUID:BE63806A-E3E0-4E00-g Redacted SURGICAL PATHOLOGY REPORT Patient: Specimen #: FMP/SSN: DOB/Age/Sex: Race: WHITE Taken: Location: Received: Physician(s) : Reported: Ics-0-3 SPECIMEN: A: RIGHT OUTER BREAST LUMPECTOMY Cacinoma, infiHf^uHng 1obulev, N0S B: HIGHEST RIGHT AXILLARY LYMPH NODE 8520f3 C: RIGHT AXILLARY LYMPH NODE DISSECTION Sits: srsst, Nos C50.9 4/07|  FINAL DIAGNOSIS: BREAST, RIGHT OUTER, LUMPECTOMY:S A. TUMOR TYPE: INVASIVE LOBULAR CARCINOMA, PLEOMORPHIC TYPE (SEE) COMMENT) . * NOTTINGHAM GRADE: POORLY DIFFERENTIATED (G3). * NOTTINGHAM SCORE: 8/9 (Tubules= 3, Nuclei= 3, Mitoses= 2). TUMOR SIZE (GREATEST DIMENSION): 3.2 CM (MEASURED GROSSLY).) TUMOR FOCALITY: SINGLE FOCUS OF INVASIVE CARCINOMA. TUMOR SIDE (QUADRANT): RIGHT OUTER. VENOUS/LYMPHATIC INVASION: PRESENT. MARGINS: POSITIVE. * TUMOR EXTENDS TO THE ANTERIOR AND INFERIOR INKED TISSUE EDGES.S LOBULAR CARCINOMA IN SITU: NOT IDENTIFIED. LYMPH NODES: TWENTY-THREE (23) LYMPH NODES POSITIVE FOR METASTATIC CARCINOMA (SEE PARTS "g" AND "C"). ESTROGEN RECEPTORS: POSITIVE (95% NUCLEI STAINING, REFER TO) PROGESTERONE RECEPTORS:  NEGATIVE (O% STAINING. REFER TO HER 2 NEU by IHC: NEGATIVE, 1+ (REFER TO - AJCC PATHOLOGIC STAGE (7TH EDITION) : pT2 N3a) B. AXILLARY LYMPH NODE, RIGHT ("HIGHEST"), BIOPSY:  ONE (1) LYMPH NODE POSITIVE FOR METASTATIC CARCINOMA (SEE COMMENT). * SIZE OF LARGEST METASTATIC DEPOSIT: 0.9 CM * EXTRACAPSULAR EXTENSION:  FOCALLY PRESENT. C. AXILLARY LYMPH NODES, RIGHT, DISSECTION: TWENTY-TWO (22) OF TWENTY-THREE (23) LYMPH NODES POSITIVE FOR METASTATIC CARCINOMA (SEE COMMENT). * SIZE OF LARGEST METASTATIC DEPOSIT: 2.1 CM * EXTRACAPSULAR EXTENSION: PRESENT. Page 1 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
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+RIVASYMCT O1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: FINAL DIAGNOSIS (continued): Comment: The lymph node metastases seen in parts "p" and "c" demonstrate multiple foci of extracapsular extension and in most cases represent near complete replacement of the underlying nodal architecture. This case received prospective peer review. * * Report Electronically Signed Out ** / CLINICAL DIAGNOSIS AND HISTORY: female with medical diagnosis of breast cancer (invasive mammary adenocarcinoma, right breast breast; positive right axillary node). PRE-OPERATIVE DIAGNOSIS: None provided. POST-OPERATIVE DIAGNOSIS: None provided. GROSS DESCRIPTION: A: Received fresh, labeled with the patient's name and designated, "Right Outer Breast Lumpectomy" and consists of an irregular portion of soft tissue oriented with a single suture - anterior; double - lateral; and short - superior.  The specimen measures 10.5 cm superior to inferior; 7.0 cm medial to lateral; and 3.0 cm anterior to posterior. The specimen is inked as follows: superior = blue; inferior  green; medial = red; lateral = yellow; anterior - orange; and posterior = black. Serial sections reveal a poorly-defined, firm tan-white mass measuring 3.2 x 2.5 x 2.0 cm. The mass approaches the closest margin as follows: 0.2 cm inferior; 0.5 cm deep and anterior; and 1.0 cm medial. The remainder of the specimen is composed of lobulated, yellow-tan adipose tissue admixed with a minimal amount of fibrous tissue and is otherwise unremarkable. Representative sections are sequentially submitted from superior to inferior as follows: Al- superior margin; A2-A4- adjacent normal; A5-A7- mass with deep and anterior margins; A8- mass; A9-A10- mass with deep margin; All-Al3- mass with deep, anterior and medial margin; Al4-Al6- mass with lateral, inferior and anterior margin; A17-Al9- mass with deep and inferior margins. Matched sections of A4 and A6-A8 are submitted in Ocr and Paraffin per Page 2 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 3 ---
+? SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION (continued) : CBcp protocol. Time in formalin: 28 hours. B: Rereived in formalin, labeled with the patient's name and designated, "Highest Right Axillary Lymph Node" and consists of an irregular fragment of tan-yellow adipose tissue measuring 1.5 x 1.0 x 0.5 cm. ~Blunt dissection reveals an ovoid fragment of tan, soft tissue representing possible lymph node measuring 1.5 cm in greatest dimension. Sectioning of the possible lymph node reveals a tan-white, firm cut surface. C: Received in formalin, labeled with the patient's name ind designated, "Right Axillary Lymph Node Dissection" and consists of an irregular fragment of tan-yellow, lobular adipose tissue. measuring 10.0 x 6.0 x 3.0 cm. The specimen is blunt dissected to reveal 22 roughly ovoid fragments of tan-white, firm tissue representing possible. lymph nodes ranging from 0.4 to 4.3 cm in greatest dimension. Sectioning of the possible lymph nodes reveals a tan-white, firm cut surface with. focal areas of hemorrhage. Sections are submitted as follows: Cl- five possible lymph nodes; c2- representative sections of four possible lymph nodes; C3- representative sections of four possible lymph node; C4- representative sections of three possible lymph nodes; C5- representative sections of two possible lymph nodes; C6- representative sections of two possible lymph nodes; c7- representative section of one possible lymph node; c8- one whole possible lymph node, bisected. Page 3 End of Report .OR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
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diff --git a/output/text/889477ce-94a7-4174-8bd8-a5be6e9b4ec3.txt b/output/text/889477ce-94a7-4174-8bd8-a5be6e9b4ec3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f246418cf3a27fb1acf375a1a7091c3e1c8663b7
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+page 1 / 2 TCGA-D5-6538 Examination: Histopathological examination Material: Total organ resection -- colon and caecum Physician in charge: Material collected on: Material received on: Expected time of examination. Clinical diagnosis: Cancer of the hepatic flexure. Examination performed Macroscopic description:. A 11,2 cm length of Iarge intestine with a fragment of mesentery sized 16 x 9 x 3 cm, an 8 cm section of a and 5.5 cm appendix. Ulcerous tumour sized 5.4 x 6.9 x 1.8 cm in the mucosa. The lesion surrounds 100% of the intestine circumference, removed 9, 3 cm from the proximal incision, 3.1 cm from the distal incision, and 1.3 cm from the Bauhin's valve. Microscopic description:. Adenocarcinoma tubulopapillare partim mucinosum (G3). Infiltratio carcinomatosa profunda tunicae muscularis propriae et telae adiposae mesenteril pericolicae. Incision lines are free of neoplastic lesions. Metastases carcinomatosae in Iymphonodis (No X/xiv). Infiltratio carcinomatosa capsulae lymphonodorum et telae adiposae perinodalis. Emboliae carcinomatosae. Appendix - Appendicitis follicularis. Histopathologic diagnosis:. Adenocarcinoma tubulopapllare partim mucinosum coli. Metastases carcinomatosae in lymphonodis (No X/xiv). Tubulopapillar and partially mucinous adenocarcinoma of the colon. Cancer metastases in lymph nodes (No X/xiV). (G3, Dukes C, Astler-Coiler C2, pT3, pN2). CONTACT YOUR DOCTOR WITH THIS REPORT!
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diff --git a/output/text/88d0c480-ee1a-4261-b675-fa30ddfe6420.txt b/output/text/88d0c480-ee1a-4261-b675-fa30ddfe6420.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5a8d05ae3dd2e3e133e6d429062ece6be30e5b76
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+1ed-0 - 3 Infibkating duct, Nos 85,otf3 Carcinmn, l Pan c50.4 CqcF Sits: brst nos c5o.9 TSS Pt Id: 1o/9/0 h SPECIMENS: A. SENTINEL LYMPH NODE #1 LEFT AXILLA B. SENTINEL LYMPH NODE #2 LEFT AXILLA UUID:AA1BACC4-0B3D-4E2E-865E-24B570DA4E74 C. SENTINEL LYMPH NODE #3 LEFT AXILLA TCGA-E2-A10A-01A-PR Redacted D. LEFT BREAST E. RIGHT BREAST SKIN SPECIMEN(S): A. SENTINEL LYMPH NODE #1 LEFT AXILLA B. SENTINEL LYMPH NODE #2 LEFT AXILLA C. SENTINEL LYMPH NODE #3 LEFT AXILLA D. LEFT BREAST E. RIGHT BREAST SKIN INTRAOPERATIVE CONSULTATION DIAGNOSIS: TP A-C: Negative for tumor. By Dr., called to Dr. GROSS DESCRIPTION: A. SENT!NEL LYMPH NODE #1 LEFT AXILLA Received fresh labeled with patient name designated "A -- sentinel lymph node #1 left axilla" is a fragment of beige-tan possible lymphoid tissue measuring 1.1 x 0.9 x 0.3 cm. The specimen is serially sectioned. Touch preps were performed. The entire specimen is submitted in cassette A1. B. SENTINEL LYMPH NODE #2 LEFT AXILLA Received fresh labeled with patient name designated "B -- sentinel lymph node #2" is a fragment of yellow-red fibroadipose tissue measuring 3.2 x 1.5 x 0.7 cm. One possible lymph node is identified measuring 1.2 x 0.6 x 0.5 cm. The specimen is bisected. Touch preps were performed. The entire lymph node is submitted in cassette B1.. C. SENTINEL LYMPH NODE#3 LEFT AXILLA Received fresh labeled with patient name designated "C -- sentinel lymph node #3 left axilla" is a fragment of beige-tan possible lymphoid tissue measuring 1.2 x 0.6 x 0.4 cm. The specimen is serially sectioned, touch preps were performed. The entire specimen is submitted in cassettes C1. D.LEFT BREAST Received fresh labeled with patient name designated "D - left breast" is a resected mastectomy specimen weighing 676 grams and measuring 22.5 x 19 x 3 cm. The specimen is received with. orientation. A suture designates the axillary end of breast. The deep margin is inked black. The overlying beige-tan ellipse of skin measures 14.5 x 4.2 cm. The light brown areola measures 3.5 cm in diameter. The everted nipple measures 1.1 cm in diameter. The specimen is serially sectioned from medial to lateral. Cut section shows a firm beige-tan mass in the upper outer quadrant approaching the. deep surgical margin at closest distance 1.3 cm and is located 5 cm from the axillary tail. The lesion measures 3.6 x 3 x 2.2 cm. This lesion extends to the lower outer quadrant for about 2.5 x 1.5 cm. A second possible lesion is noted in the upper outer quadrant superior to the first main mass approaching. the deep surgical margin at a distance of 2.5 cm. This area is located 5.2 cm from the first lesion and measures 0.5 x 0.5 x 0.4 cm. A third possible subareolar is noted located 4.5 cm from the first main mass in the upper outer quadrant. This third lesion measures 0.6 x 0.5 x 0.5 cm. A fourth possible mass is located approximately 2.5 cm from the main mass in the upper outer quadrant and approaches the deep margin at a distance of 2.2 cm. The fourth lesion measures 0.5 x 0.3 x 0.3 cm. The remainder of the breast parenchyma shows multiple patchy fibrous firm tissue. A portion of the specimen is submitted for tissue procurement. Representative sections are submitted as follows: D1-D3: the main mass in the upper outer quadrant with overlying deep margin D4-D5: remainder of the main mass in the upper outer quadrant D6: lesion #2 upper outer quadrant D7: lesion #3 subareolar D8: lesion #4 upper outer quadrant D9-D10: additional firm fibrous tissue adjacent to main mass of lower outer quadrant D11-D14: additional section lower outer quadrant D15-D16: fibrous tissue central subareolar D17-D18: representative sections upper inner quadrant D19-D21: representative sections lower inner quadrant D22: section of nipple D23: representative sections of skin
+
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+D24-D28: multiple possible axillary lymph nodes E. RIGHT BREAST TISSUE SKIN  Received in formalin in a container labeled with the patient name designated "e. right breast skin" is an irregular fragment of beige-tan skin measuring 11.4 x 4.5 x 0.3 cm. The surface of the specimen is unremarkable. A section shows unremarkable skin tissue. Representative sections are submitted in cassettes E1-E3. DIAGNOSIS: A. SENTINEL LYMPH NODE #1, LEFT AXILLA, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR TUMOR (O/1). B. SENTINEL LYMPH NODE #2, LEFT AXILLA, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR TUMOR (0/1). C. SENTINEL LYMPH NODE #3, LEFT AXILLA, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR TUMOR (0/1). D: LEFT)BREAST, MASTECTOMY: -INVASIVE DUCTAL CARCINOMA, MULTIFOCI, SBR GRADE II. - SIZE OF LARGEST TUMOR FOCUS MEASURING 6.1 X 4.5 CM. - DUCTAL CARCINOMA IN-SITU, CRIBRIFORM AND MICROPAPILLARY TYPES - ATTACHED SKIN AND NIPPLE, NEGATIVE FOR TUMOR.E - SURGICAL RESECTION MARGINS, NEGATIVE FOR TUMOR. - SEE TEMPLATE. SYNOPTIC REPORT - BREAST Specimens Involved Specimens: D: LEFT BREAST Specimen Type: Mastectomy Needle Localization:  No Laterality:rLeft Invasive tumor: Present Multifocality: Yes WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Specimen size: Size of Invasive focus 6.1cm Additional dimensions: 4.5cm x 2.2cm Tumor Site: Upper outer quadrant Lower outer quadrant. Margins:  Negative Distance from closest margin:1.3cm Margin: deep Tubular score: 2 (10-75% tubule) Nuclear grade: 2 Mitotic score (Olympus 40x):2 (7-13/10 Modified Scarff Bloom Richardson Grade: I (6-7 points) Necrosis: Present Vascular/Lymphatic Invasion:  Indeterminate Lobular neoplasia:. None Lymph nodes: Sentinel lymph node only Lymph node status: Negative 0/3  Non-neoplastic areas: Fibrocystic disease, pseudoangiomatous stromal hyperplasia DCIS present DCIS Quantity: Estimate % 10 DCIS type: Cribriform  Micropapillary DCIS location: Associated with invasive tumor Nuclear grade: Intermediate Necrosis: Absent Location of CA++: Benign epithelium Pathological staging (pTN): pT 3N 0 Comment(s): See breast biomarker template
+
+--- Page 3 ---
+SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimens Involved Specimens: D: LEFT BREAST SPECIMEN: Other mastectomy Block Number: D4 ER: Positive - Allred Score: 7 = Proportion score: 4 + Intensity Score 3 PR: Positive - Allred Score:.  8 = Proportion Score 5 + Intensity Score 3 COMMENT: The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the. proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of. cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring. range from 0 to 8. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2. Methodology: Fixation Type and Length: Tissue was fixed in 10% neutral buffered formalin : ) for no less than 8 and no lonaer than 24 hours. Antibody and Assay Methodology:. Mouse anti-human ER and PR, Comment: This assay can be used to select invasive breast cancer patients for hormone therapy (1) ER and PR analysis was performed on this case by immunohistochemistry utilizing the ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) antibody provided by  following the manufacturer's instructions listed in the package insert. This assay was not modified, and adherence to all instruction and guidelines were strictly followed. Interpretation of the ER/PR immunohistochemical staining characteristics is guided by published results in the medical literature (1), information provided by the reagent manufacturer and by internal review of staining performance within the Pathology Department. 1. Harvey JM, et al. Estrogen receptor status by immunohistochemistry is superior to the ligand-binding. assay for predicting response to adjuvant endocrine therapy in breast cancer. J Clin Oncol. 17:1474- 1481, 1999 CLINICAL HISTORY:  None given PRE-OPERATIVE DIAGNOSIS: Left breast ca ADDENDUM: E. RIGHT BREAST SKIN, EXCISION: - FRAGMENT OF UNREMARKABLE SKIN, NEGATIVE FOR TUMOR. PathVysion HER-2 DNA Probe Kit Case No Analytical Interpretation of Results: HER-2 NOT AMPLIFIED Clinical Interpretation of results Amplification of the HER-2 gene was evaluated with interphase fluorescence in-situ. hybridization (FiSH) on formalin-fixed paraffin embedded tissue sections using a chromosome 17 centromeric probe and a HER-2 probe that spans the entire HER-2 gene in the. I. A majority of tumors cells displayed 2 chromosome 17 signals ana 2 HER-2 signals, with a HER-2/CEP 17 Ratio </=2.0, consistent with no. amplification of the HER2/neu gene. Block used D4 Source of case:RPCI Tissue fixation formalin-fixed tissue Outside Case No:NA Tissue source breast Results interpreted: yes HER2/CEP17 ratio: 1.21 This ratio is derived by dividing the total number of LSI HER-2/neu signals by the total number of. CEP17 signals in at least 20 interphase nuclei with nonoverlapping nuclei in the neoplastic.  mammary epithelial cells. Cells with no signals or with signals of only one color are disregarded.
+
+--- Page 4 ---
+Method of ratio enumeration: manual count. Limitations The Vysis PathVysion Kit is not intended for use to screen for or diagnose breast cancer. It is intended to be used as an adjunct to other prognostic factors currently used to predict disease-free and overall survival in stage Il, node-positive breast cancer patients. In making decisions regarding adjuvant CAF treatment, all other available clinical information should also be taken into consideration, such as tumor size, number of involved lymph nodes, and steroid receptor status. No treatment decision for stage Il, node-positive breast cancer patients should be based on HER- 2/neu gene amplification status alone. Overview of this test FDA APPROVED REAGENT PathVysion HER-2 DNA Probe Kit is FDA approved for selection of patients for whom Herceptin therapy is being considered. These tests were performed in the under the direction of The results of these studies should always be interpreted in the context of the clinical, morphological, and immunophenotypic diagnosis.. Gross Dictation:, Microscopic/Diagnostic Dictation:., Pathologist,. Microscopic/Diagnostic Dictation: Pathologist, Microscopic/Diagnostic Dictation: Patholnnist Final Review: Pathologist, Final: Pathologist, Addendum: Patholoyist, - Addendum Final: Pathologist, I Addendum: Pathologist, Addendum Review: Pathuiuyist, Addendum Final:., Pathologist,  Addendum: Pathologist, Addendum Final:, Patholuyist,
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diff --git a/output/text/88d31c94-959d-4b1a-b057-77337a4c00a3.txt b/output/text/88d31c94-959d-4b1a-b057-77337a4c00a3.txt
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index 0000000000000000000000000000000000000000..33bb736602a22832794216ec941d5c1fa5b75352
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+
+--- Page 1 ---
+CGA-AD-5900 QC Pathologist: FINAL PATHOLOGIC DIAGNOSIS Right colon,segmental resection Tumor Characteristics: Histologic type:Adenocarcinoma,with focal mucinous features. Location of tumor: Right colon. Size3.2x2.4x0.5 cm. Grade (lf applicable to tumor type):Low-grade (moderately differentiated) Lymphovascular space invasion:No Perforation of visceral peritoneum:No. Presence of mesenteric deposits:No. Depth of invasion/extent of invasion: Tumor penetrates into superficial muscularis propria. Surgical Margin Status: Proximal margin:Negative by 8.2 cm. Distal margin:Negative by 5.4 cm. Deep radial) margin: N/A tumor does not erupt serosal surface Lymph Node Status: Total number of lymph nodes examined:11. Total number of lymph nodes containing metastatic carcinoma 00/11. Other: 1.Other significant findings: Tumor arises within tubular adenoma with high-grade dysplasia. 2.TNM stage:T2 NO MX. COMMENTS: CLINICAL HISTORY: Preoperative Diagnosis ascending colon mass;high grade dysplasia Postoperative Diagnosis: Symptoms/Radiologic Findings: SPECIMENS: Right colon
+
+--- Page 2 ---
+GROSSDESCRIPTION: and right Received in one container labeled colon a previously opened right colectomy specimen received for research.The terminal ileum measures 3.5x 1.7 cm in diameter,the cecum and colon together measure 12.1 x6.1 cm in diameter and the attached appendix measures 2.5 x 0.6 cm. The specimen is covered by a moderate amount ot pericolonic adipose tissue.On opening there is a 3.2x2.4 x0.5 cm tan firm raised mass,5.4 cm from the distal margin and 8.2 cm from the proximal margin.On section the lesion has a solid tan cut surface'and is 0.4 cm thick.Grossly it does not pertorate through the wall. The remainder of the lumen is lined by normal appearing tan mucosa.The appendix is grossly uninvolved by lesion. After using the Reveal solution, ten lymph nodes are identified ranging from0.3x0.2 x0.1 cm to 1.5 x 0.9 x 0.6 cm.Representative sections are submitted as follows: 1--proximal margin2--distal margin3-5--representative sections of lesion;6-representative appendix; 7--representative ileocecal valve8--one node sectioned, 9--three whole nodes;10-12--two whole nodes in each cassette.Two cassettes for research labeled
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diff --git a/output/text/88d32659-ab36-4512-b559-b16b6f1d2037.txt b/output/text/88d32659-ab36-4512-b559-b16b6f1d2037.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ecced33681a613655cc1bce2d3e91843951c679e
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+
+--- Page 1 ---
+UUID:AB5DCF8B-A35D-4B20-A108-AB443795D3F3 Redacted Pathology Review /cs-0-3 Carciioms, wrothcirl,N0s 813o/3 Sits: b/odw,antrinhnll Cb7.3 DIAGNOSIS (A) LEFT VAS: Segment of vas deferens, no tumor present. (B) LEFT URETER: Segment of ureter with mild reactive atypia, no tumor present.. (C) RIGHT VAS: Segment of vas deferens, no tumor present. (D) RIGHT URETER: Segment of ureter, no tumor present. (E) BLADDER, PROSTATE AND SEMINAL VESICLES:S Bladder: UROTHELIAL CARCINOMA, NONPAPILLARY TYPE, GRADE 3. TRANSMURAL INVASION OF BLADDER WALL WITH FOCAL EXTENSION INTO PERIVESICAL ADIPOSE TISSUE UROTHELIAL CARCINOMA IN SITU IN A BACKGROUND OF DIFFUSE LOW GRADE INTRAUROTHELIAL NEOPLASIA. Serosal and resection margins, free of tumor. Prostate: Prostate with microcystic adenomatous change. No evidence of malignancy. (F) RIGHT COMMON ILIAC LYMPH NODES: Fibroadipose tissue, no lymph node or tumor present.. (G) RIGHT EXTERNAL ILIAC LYMPH NODE: Four lymph nodes, no tumor present (0/4). (H) RIGHT OBTURATOR LYMPH NODE: Seven lymph nodes, no tumor present (0/7) (I) LEFT COMMON ILIAC: Five lymph nodes, no tumor present (0/5). (J) LEFT EXTERNAL ILIAC: Two lymph nodes, no tumor present (0/2). (K) LEFT OBTURATOR: Ten lymph nodes, no tumor present (0/10) (L) LEFT URETER, FINAL MARGIN: Wall of ureter, no tumor present. (M) RIGHT URETER, FINAL MARGIN: Wall of ureter, no tumor present. GROSS DESCRIPTION
+
+--- Page 2 ---
+(A) LEFT VAS - A white-tan portion of vas deferens measuring 5 cm in length x 0.3 cm in diameter. A lumen is present on the cut surfaces. Specimen is representatively submitted in A. (B) LEFT URETER -- A segment of ureter 0.8 cm long and 0.1 cm in diameter with surrounding fibroadipose tissue. The resection margin is inked by the surgeon and entire. specimen is submitted for frozen in block B (ink side down, en face). *FS/DX: BENIGN URETER. (C) RIGHT VAS -- A segment white-tan vas deferens measuring 5.5 cm in length x 0.3 cm in diameter. A pinpoint lumen is visible in the cut surfaces. Specimen is representatively submitted in C. (D) RIGHT URETER-- A segment of ureter (1.0 x 0.7 cm). The margin, designated by the surgeon with ink, is reinked blue and submitted en face for frozen section in D. *FS/DX: BENIGN URETER (E) BLADDER, PROSTATE AND SEMINAL VESICLES - A cystoprostatectomy measuring overall (14 x 7.5 x 7 cm). The specimen is opened longitudinally through the superior wall to reveal a fungating tumor (9 x 7 x 2.5 cm) involving the near entire  anterior bladder wall and dome. The tumor appears to invade the muscular wall of the. bladder but does not extend into the perivesical adipose tissue.  The remaining bladder mucosa shows hemorrhage, especially in the trigone, and is other unremarkable.. INK CODE: Black - outer surface of anterior wall SECTION CODE: E1-E48, bladder with tumor; E49-E57, prostate; E58, E59, urethra, en face.. (F) RIGHT COMMON ILIAC LYMPH NODES - A singIe red tan piece of tissue measuring 2.4 x 1.5 x 1 cm. Three potential lymph nodes are palpated, ranging in size from 0.4 to 0.6 cm in greatest dimension. No tumor is seen grossly. Specimen is entirely submitted. SECTION CODE: F1, three potential lymph nodes; F2, remainder of specimen. (G) RIGHT EXTERNAL ILIAC LYMPH NODE - Multiple red tan pieces of adipose tissue measuring 4.9 x 4 x 1 cm in aggregate. Five possible lymph nodes are found, ranging in size from 0.5 to 3.7 cm in greatest dimension. No tumor is seen grossly. Specimen is entirely submitted. SECTION CODE: G1, three potential lymph nodes; G2, G3, single lymph node; G4, G5, single lymphnode. (H) RIGHT OBTURATOR LYMPH NODE - Multiple red tan pieces of adipose tissue measuring 5 x 2.5 x 2 cm in aggregate. Seven potential lymph nodes are found, ranging in size from 0.4 to 2.6 cm in greatest dimensions. No tumor is seen grossly. SECTION CODE: H1, four potential lymph nodes; H2, one potential lymph node; H3, one potential lymph node; H4, H5, single lymph node, sectioned. (I) LEFT COMMON ILIAC -- Received is a 3.5 x 3.0 x 1.0 cm portion of fibroadipose tissue, which yields multiple possible lymph nodes, ranging from 0.6 cm to 1.5 x 0.8 x 0.6 cm. The lymph nodes are submitted entirely. SECTION CODE: I1, three lymph nodes; I2, two lymph nodes.
+
+--- Page 3 ---
+(J) LEFT EXTERNAL ILIAC -- Received is a 5.0 x 4.2 x 1.0 cm portion of fibroadipose tissue which yields two possible lymph nodes, measuring 2.0 x 0.8 x 0.5 cm and 3.0 x 1.5 x 0.5 cm. Both lymph nodes are submitted entirely. SECTION CODE: J1, one lymph node; J2, J3, one lymph node, serially sectioned. (K) LEFT OBTURATOR - Multiple fibroadipose tissue fragments (6.5 x 4.0 x 1.0 cm) Eleven possible lymph nodes, ranging from 0.5 to 2.5 cm in greatest dimension are identified and are submitted in toto. SECTION CODE: K1, four Iymph nodes; K2, three lymph nodes; K3, one lymph node, bisected; K4, one lymph node, bisected; K5, one lymph node, bisected; K6, one lymph node, bisected. (L) LEFT URETER FINAL MARGIN A segment of ureter (1.7 x 0.6 cm). The true margin. designated by the surgeon with ink, is reinked blue and submitted en face in L. (M) RIGHT URETER FINAL MARGIN -- A segment of ureter (0.8 x 0.8 cm). The margin, designated by the surgeon with ink, is reinked blue and submitted en face in M CLINICAL HISTORY None given.
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diff --git a/output/text/88f73d96-be2a-45b9-a533-f5a9a3979d67.txt b/output/text/88f73d96-be2a-45b9-a533-f5a9a3979d67.txt
new file mode 100644
index 0000000000000000000000000000000000000000..172c40d7c7f7ddb32347bb2375c2490e88b92f76
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+
+--- Page 1 ---
+FINAL DIAGNOSIS: RighT bREaSt At 2 O'ClOCK, SEGmenTal mAsTecTOmy - INEILTRATing DuCtaL CArcinoMA, nOTTIngham GrADe 1 (nUCLEAR GRADE 2, TUBULE SCORE 2, A. MITOTIC ACTIVITY SCORE 1, TOTAL SCORE 5/9) (see comment). B. TUMOR MEASURES 0.7 CM IN GREATEST DIMENSION. C.  NO DEFINITE LYMPHOVASCULAR INVASION IS IDENTIFIED. D. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 1, SOLID TYPE WITH CALCIFICATIONS. E. MARGINS ARE NEGATIVE; iNFILTRATING CARCINOMA IS 0.8 CM FROM THE CLOSEST MARGIN; DCIS IS 0.1 CM FROM THe iNFERiOR MARGIN. F. ATYPICAL. DUCTAL HYPERPLASIA. G. CHAnGES CONSISTENT WITH PREVIOUS BIOPSY SITE. 1cs-0-3 H. FIBROCYSTIC CHANGES. Carcinmme, infi/tnsfng ductd,nos 85o0f3 Sit:brusst, Nts c5o.9 CASE SYNOPSIS 3/13|1 d SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST LATERALITY: Right PROCEDURE: Segmental LOcATiOn: Upper inner quadrant SIZE OF TUMOR: Maximum dimension invasive component: 0.7 cm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: No TUMOR TYPE (invasive component): Ductal adenocarcir  NOTTINGHAM SCORE: Nuclear grade. Tubule formation:2. Mitotic activity score:1. Total Nottingham score.? Nottingham grade (1, 2, 3). ANGIOLYMPHATIC iNVASION: No DERMAL LYMPHATIC INVASION: Not applicable CALCIFICATION: Yes, malignant zones TUMOR TYPE, iN SITU: Solid SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No Distance of invasive tumor to closest margin: 8 mm SURG MARGINS INVOLVED BY IN SITU COMPONENT: No Distance of in situ disease to closest margin: 1 mm PAGET'S DISEASE OF NIPPLE: No LYMPH NODES POSITIVE: 0 LYMPH NODES EXAMINED: 0 METHOD(S) OF LYMPH NODE EXAMINATION: Other: N/A t Stage, PathOlOgIC: pT1b N Stage, PatholOgIC: pNX UUID:93292768-8C20-4551-8CA8-44AE0FFB487E M STAgE, PATHOLOgIC: pMX TCGA-BH-A0H6-01A-PR Redacted ESTROGEN RECEPTORS: positive PROGESTERONE RECEPTORS: positive HER2/NEU: zero or 1+
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diff --git a/output/text/8913c587-809a-4bd3-bf56-f31cfc2dd8a8.txt b/output/text/8913c587-809a-4bd3-bf56-f31cfc2dd8a8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..aff10b7c754596acd8d939f5b1f43c9eee987d18
--- /dev/null
+++ b/output/text/8913c587-809a-4bd3-bf56-f31cfc2dd8a8.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:D5C9D3FF-3799-4773-8A86-B000DBE42BD8 Redacted TSS Patient ID Case #: JOB: Sex: Female Ethnicity (Race): Cancer Sample Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma. Date of Procurement:. Anatomic Site: Breast Tumor location: Primary. Tissue Specification: Tumor Specimen Matrix: Tissue Specimen Format: OCT. Container: block Type of Procurement: surgery Grade: 2. T Stage: 1c N Stage: 1a M Stage: 0 Treatment: none Treatment Details: n/a. Normal Sample Anatomic Site: Blood Sample Type: Norma! Type of Procurement: blood draw Matrix: Blood Specimen Format: frozen Container: tube Date of Procurement:. Ics-0- 3 carcianw,lifiHtrahnq oluct,nos 85oof3 Site: breast, nos .50.J 10/31f L/o/at/
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diff --git a/output/text/89266c6d-3340-42b7-b550-7e481358d3cc.txt b/output/text/89266c6d-3340-42b7-b550-7e481358d3cc.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2c5281a58e0622d2b53c056ae9ae95de06be926e
--- /dev/null
+++ b/output/text/89266c6d-3340-42b7-b550-7e481358d3cc.txt
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+
+--- Page 1 ---
+UUID: 54CDEB1D-8CF9-4723-9A7D-CD9DFEDFD659 Redacted TCGA-DD-AACI-01A-PR CLINICAL DIAGNOSIS: R/O Carcinosarcoma Specimen : liver Gross Photo : 1 GROSS: 1. Specimen: ID-0.3 Liver: 10.0 x 9.0 x 12.0 cm, fixed 2. Tumor location: left 8170/3 Tumor number: one Tumor size: 5.5 x 3.5 x 5.0 cm Ste: iuer Ca3.0 3. Satellite nodule: no 4. Gross type QsJs/19/i<j HCC: expanding nodular 5. Tumor necrosis: no 6. Hemorrhage/peliosis: no 7. Portal vein invasion: yes 8. Bile duct invasion: no 9. Others: dystrophic calcification in the fibrotic septa, centra Gross photo present. Blocks T1-4, TB, tumor and surrounding liver tissue x 5 L, NB, remaining liver tissue x 2 RM, resection margin of liver x 1 A, labeled "tumor emboli" x 1 MICROSCOPIC: 1. Hepatocellular carcinoma: yes 1-1. Differentiation The worst differentiation: III The major differentiation: III 1-2. Histologic type: trabecular and solid 1-3. Cell type: hepatic 1-4. Fatty change: yes (30-40 %) 2. Other tumor: no 3. Fibrous capsule formation: partial 4. Capsular infiltration: yes 5. Septum formation: partial 6. Surgical resection margin invasion: no
+
+--- Page 2 ---
+7. Serosal invasion: no 8. Portal vein invasion: yes 9. Bile duct invasion: no 10. Hepatic vein invasion: no 11. Hepatic artery invasion: no 12. Microvessel invasion: no 13. Intrahepatic metastasis: no 14. Multicentric occurrence: no 15. Others: dystrophic calcification is present Non-tumor liver pathology 1. Chronic hepatitis: yes 1-1. Etiology: unknown cause 1-2. Grade, lobular: minimal (grade I) 1-3. Grade, portoperiportal: minimal (grade I) 1-4. Stage (fibrosis): precirrhotic (stage III-IV) 2. Dysplastic nodule: no 3. Ductal epithelial dysplasia: no 4. Other liver diseases: no SPECIAL STAIN: Reticulum stain shows arrangement of tumor cells. Trichrome stain shows fibrotic septum. NOT reported. Gross: Bile duct, smear, inflammation Bile duct, smear, inflammation. liver,needle,hepatocellular carcinoma Liver, ectomy, hepatocellular carcinoma, cholangiocytic differentiation, precirrhotic fibrosis T56000, P10, M81703, cholangiocytic differentiation, precirrhotic fibrosis. DIAGNOSIS:
+
+--- Page 3 ---
+Liver, segment, left, segmentectomy: Hepatocellular carcinoma, moderately differentiated. with cholangiocytic differentiation (see NOTE) Precirrhotic fibrosis NOTE: Tumor cholangiocytic differentiation hepatocellular carcinoma Suggestion : hw113[14
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index 0000000000000000000000000000000000000000..de1a006fde017030da1c0e11bf599dc785c6ca12
--- /dev/null
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+--- Page 1 ---
+TcgA 8004 Finalpathology Diagnosis Report Accession Number: Senior Pathologist: Collected Date/Time: Received Date/Time;. Verified Date/Time:. Final Pathologic Diagnosis A) RIGHT LEVEL I (RADICAL NECK DISSECTION): Metastatic squamous cell carcinoma in 2 of 4 Iymph nodes (2/4).. Submandibular gland with chronic sialadenitis; negative for. neoplasia. B) RIGHT LEVEL II (RADICAL NECK DISSECTION): Metastatic squamous cell carcinoma in 3 of 11 Iymph nodes (3/11). C) RIGHT LEVEL III (RADICAL NECK DISSECTION): Metastatic squamous cell carcinoma in 1 of 9 Iymph nodes (1/9) Positive for extranodal extension.. Intranodal thyroid tissue consistent with metastatic papillary thyroid carcinoma, follicular variant.. D) RIGhT LEVEL Vi (RADICAL NECK DiSSECTION): Nine lymph nodes negative for neoplasia (0/9) E) LEFt LEVEL I (RADICAL NECK DISSECTION): Metastatic squamous cell carcinoma in 1 of 9 Iymph nodes (1/9). Submandibular gland with chronic sialadenitis and atrophy; negative. for neoplasia. F) LEFT LEVEL II (RADICAL NECK DISSECTION): Metastatic squamous cell carcinoma in 5 of 14 lymph nodes (5/14). G) LEFT LEVEL iII (RADICAL NECK DISSECTION): Seven lymph nodes negative for neoplasia (0/7). H) LEFT LEVEL VI (RADICAL NECK DISSECTION): Nine lymph nodes negative for neoplasia (0/9).. Page: 1 of 7
+
+--- Page 2 ---
+FinalPatnology Diagnosis Reporl ccesston Number: Senior Pathologist: Collected Date/Time: Received Date/Time: Verified Date/Time: I) BILATERAL SUBMENTAL LYMPH NODES (RADICAL NECK DISSECTION): Metastatic squamous cell carcinoma in 2 of 4 lymph nodes (2/4) Positive for extranodal extension. J) TONGUE, FLOOR OF MOUTH AND MANDIBLE (COMPOSITE RESECTION OF FLOOR OF MOUTH, SEGMENTAL MANDIBULECTOMY, AND TOTAL GLOSSECTOMY): Well to moderately differentiated infiltrating squamous cell carcinoma (see synoptic report). K) DEEP TONGUE MARGIN (BIOPSY): Negative for neoplasia. L) ANTERIOR TONGUe (bIOpSY): Negative for neoplasia. M) LEfT LATEral (BIOpSY): Negative for neoplasia. N) RIGHT LATERAL (BIOPSY): Negative for neoplasia. I attest I have personally reviewed the specimen/slides and agree with the above findings. Resident: Page: 2 of 7
+
+--- Page 3 ---
+Final Pathology Diagnosis Report Accession Number: Senior Pathologist: Collected Date/Time: Received Date/Time: Verified Date/Time: Synoptic Report J: Upper Aerodigestive Tract, Macroscopic SPECIMEN TYPE: Resection (specify type): Composite resection floor of mouth, segmental mandibulectomy, total glossectomy and bilateral radical neck dissection. TUMOR SITE: Oral Cavity TUMOR SIZE: Greatest dimension: 7 cm *Additional dimensions: 6 x 3 cm J: UPPER AERODIGESTIVE TRACT, MICRO - MCGH HISTOLOGIC TYPE: Squamous cell carcinoma, conventional HISTOLOGIC GRADE: G2: Moderately differentiated PRIMARY TUMOR (pT): Lip and OraI Cavity: pT4a: Oral Cavity: Tumor invades adjacent structures (eg, through cortical bone, into deep [extrinsic] muscle of tongue [genioglossus, hyoglossus, palatoglossus, and styloglossus], maxillary sinus, skin of face) PRIMARY TUMOR (pT): Oropharynx REGIONAL LYMPH NODES (pN): All Aerodigestive Sites Except Nasopharynx: pN2c: Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension Number examined: 76 Number involved: 14 *EXTRA-CAPSULAR EXTENSION OF NODAL TUMOR: *Present DISTANT METASTASIS (pM): pMX: Cannot be assessed MARGINS: Margins uninvolved by tumor Distance of tumor from closest margin: 0.6 mm Specify margin, if possible: Anterior gingival *VENOUS/LYMPHATIC (LARGE/SMALL VESSEL) INVASION (V/L): *Present PERINEURAL INVASION: Absent *ADDITIONAL PATHOLOGIC FINDINGS: Page: 3 of 7
+
+--- Page 4 ---
+Final Pathology Diagnosis Reporl Accession Number: Senior Pathologist: Collected Date/Time:  Received Date/Time: Verified Date/Time:. Metastatic thyroid carcinoma (follicular variant of papillary) in right level Ill lymph node. Intraoperative Diagnosis K1: Negative for carcinoma. L1: Negative for carcinoma. M1: Negative for carcinoma. No in situ/ invasive carcinoma. N1: Negative for carcinoma. Clinical History male with tongue squamous cell carcinoma. Pre/Post-operative Diagnosis. Tongue squamous cell carcinoma cancer. Gross Anatomic Description. (Dictated by Specimens received in fourteen containers. Specimen A: Designated "right level I' is received in formalin labeled with the patient's name and "right level I'. Specimen consists of two fragments of pink/ tan soft tissue measuring 3.5 x 2.5 x 1 cm and 2 x 1.5 x 0.8 cm. Cut surfaces show tan lobulated soft cut surfaces (possible submandibular gland) and two possible lymph nodes, each measuring 0.5 x 0.5 x 0.5 cm. Section code: A1 -- possible two lymph nodes bisected; A2 -- soft tissue bisected (possible lymph node); A3 - representative sections from possible submandibular gland. Specimen B: Designated "right level II' is received in formalin labeled with the patient's name and "right level II". Specimen consists of two fragments of fibroadipose tissue measuring 5 x 3 x 1.5 cm and 3 x 1 x 0.4 cm. Multiple lymph nodes are dissected. Section code: B1 - individual lymph node; B2  bisected lymph node; B3-B4  one bisected lymph node; B5 - soft tissue bisected (possible lymph node). Specimen C: Designated "right level III" is received in formalin labeled with the patient's name and "right level IlI". Specimen consists of a pink/ tan fibroadipose tissue fragment measuring 5 x 1.5 x 0.3 cm. The specimen is dissected for lymph nodes. Page: 4 of 7
+
+--- Page 5 ---
+FinalPathology Diagnosis Report Accession Numher:. Senior Pathologist: Collected Date/Time: Received Date/Time: Verified Date/Time: Four possible lymph nodes dissected. Section code: C1  individual lymph nodes; C2 -- one bisected lymph node; C3 - one bisected lymph node. Specimen D: Designated "right level VI' is received in formalin labeled with the patient's name and "right level VI. Specimen consists of a pink/ yeilow/ tan fibroadipose tissue fragment measuring 3 x 2 x 0.4 cm. The specimen is dissected for lymph nodes. Section code: D1  multiple possible lymph nodes; D2 - two lymph nodes bisected. Specimen E: Designated "left level I is received in formalin labeled with the patient's name and "left level I". Specimen consists of pink/ tan soft tissue fragments measuring 4.5 x 2.5 x 0.7 cm and 3 x 2 x 0.2 cm. The larger fragment has yellow/ tan lobulated soft cut surfaces. The smaller fragment consists of three possible lymph nodes. Section code: E1 -- one lymph node bisected; E2 -- multiple lymph nodes; E3  one lymph node bisected; E4 - representative section from the larger fragment (possible salivary gland).. Specimen F: Designated "left level II" is received in formalin labeled with the patient's name and "left level ll'. Specimen consists of a pink fibroadipose tissue fragment measuring 7 x 3.5 x 1 cm. Four matted lymph nodes and one non-matted lymph node are dissected. The matted lymph nodes range in size from 1.5 x 1.5 x 0.5 cm to 4 x 2 x 1 cm. The non-matted. lymph node measures 1.8 x 1 x 0.3 cm. Representative sections are submitted. Section code: F1-F3 - largest matted Iymph node entirely submitted; F4  second largest matted lymph node submitted entirely; F5 - third largest matted lymph node bisected and submitted entirely; F6 - smallest matted lymph node bisected and. submitted entirely; F7  one lymph node bisected.. Specimen G: Designated "left level IIl" is received in formalin labeled with the patient's name and "left level IlI". Specimen consists of fibroadipose tissue fragment measuring 4.5 x 1 x 0.4 cm. The specimen is dissected for lymph nodes. All of the. dissected lymph nodes are submitted.. Section code: G1-G2 - one bisected lymph node; G3  multiple possible lymph nodes. Specimen H: Designated "left level VI' is received in formalin labeled with the patient's name and "left level VI'. Specimen consists of a purple soft tissue fragmented admixed with adipose tissue measuring 5.5 x 1.5 x 0.5 cm. The specimen is. dissected for multiple lymph nodes. Section code: H1-H2  multiple lymph nodes.. Specimen l: Designated "bilateral submental lymph node' is received in formalin labeled with the patient's name and "bilateral submental lymph node". Specimen consists of a soft tissue fragmented measuring 3.5 x 2.5 x 1.5 cm. Two lymph nodes measuring 2.5 x 1.5 x 1 cm and 1.5 x 1.0 x 0.4 cm are dissected. Section code: I1 -- bisected portion of the largest lymph node; I2  bisected smaller lymph node. Specimen J: Designated "composite, mandibulectomy glossectomy and floor of mouth' is received in formalin labeled with. the patient's name and "composite, mandibulectomy glossectomy and floor of mouth ". Specimen consists of a. Page: 5 of 7
+
+--- Page 6 ---
+FinaI pathology Diagnosis Report Accession Number:. Senior Pathologist: Collected Date/Time: Received Date/Time: Verified Date/Time: mandibulectomy specimen with attached tongue and floor of mouth measuring 10 cm from anterior to posterior, 7.5 cm from right to left and 8 cm in height. The jaw measures 15 cm in total length, 4.8 cm in width and 1.5 cm in thickness. Four teeth are noted. The inferior aspect of the tongue has a white firm irregular shaped mass measuring 7 x 6 x 3 cm. The mass is located 0.6 cm from the closest posterior margin and 0.6 cm from the closest inferior margin. The tumor grossly extends into the mid anterosuperior region of the mandible and into the attached portion of midanterior gingiva. Representative sections are submitted. Sections of bone are submitted following decalification. Gross photographs are taken. Inking code: Black - posterior; Red -- anterior; Green -- lateral, inferior. Section code: J1 -- J3 - anterior aspect of gingiva midline to lateral right side; J4-J7 -- anterior aspect of gingiva midline to lateral left side; J8-J10 - tumor with closest posterior margin J11  inferior margin; J12  representative sections of tumor; J13 -- J14 - anterior portion of body of mandible; J15  left ramus margin; J16  right ramus margin; J17-tumor with inferior gingival mucosa; J18 - possible tumor with the closest inferior margin. Specimen K: Designated "deep tongue margin" is received fresh for intraoperative consultation and frozen section diagnosis on labeled with the patient's name and "deep tongue margin". Specimen consists of a fragment of red/ tan soft tissue measuring 1.5 x 1 x 0.3 cm. The entire specimen is submitted for frozen section diagnosis. Section code: K1 - frozen section control. Specimen L: Designated "anterior tongue margin' is received fresh for intraoperative consultation and frozen section diagnosis on labeled with the patient's name and "anterior tongue margin" Specimen consists of three tan soft tissue fragments measuring 0.4 x 0.4 x 0.7 cm, 1 x 0.4 x 0.2 cm and 3 x 0.7 x 0.3 cm. The largest fragment is bisected. All are submitted for frozen section diagnosis.. Section code: L1  L2 - frozen section diagnosis.. Specimen M: Designated "left lateral' is received fresh for intraoperative consultation and frozen section diagnosis on labeled with the patient's name and "left lateral'. Specimen consists of three tan soft tissue fragments measuring O.5 x 0.3 x 0.2 cm, 1.5 x 0.4 x 0.2 cm and 1.5 x 0.3 x 0.4 cm. The specimen is entirely submitted for frozen section diagnosis. Section code: M1 -- frozen section control.. Specimen N: Designated "right lateral" is received fresh for intraoperative consultation and frozen section diagnosis on Jabeled with the patient's name and "left lateral". Specimen consists of four tan/ red soft tissue fragments measuring 0.4 x 0.2 x 0.1 cm, 0.5 x 0.2 x 0.1 cm, 0.6 x 0.5 x 0.2 cm and 0.9 x 0.4 x 0.2 cm respectively. The specimen is entirely submitted for frozen section diagnosis.. Section code: N1 -- frozen section control.. Page: 6 of 7
+
+--- Page 7 ---
+Intraoperatiye Diaynosis Report Accession Number: Senior Pathologist: Collected Date/Time: Received Date/Time: Verified Date/Time: Intraoperative Diagnosis. K1: Negative for carcinoma L1: Negative for carcinoma. M1: Negative for carcinoma. No in situ/ invasive carcinoma N1: Negative for carcinoma. Page: 7 of 7
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diff --git a/output/text/8940581d-a89b-4289-9f66-8d77651b0aa1.txt b/output/text/8940581d-a89b-4289-9f66-8d77651b0aa1.txt
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index 0000000000000000000000000000000000000000..985ade1295870e397fc77d238d26cd629e71ea38
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+--- Page 1 ---
+TCGA-B0-4703 FINAL DIAGNOSIS LEFT KIDNEY, NEPHRECTOMY A.  RENAL CELL CARCINOMA, CONVENTIONAL (CLEAR) CELL TYPE WITH SARCOMATOID FEATURES WITH LArge "rhabDOiD"-type Cells with Bizarre Atypia (See Comment). B. FUHRMAN NUCLEAR GRADE IS 4/4. C. RENAL CELL CARCINOMA GROWS IN ACINAR, PAPILLARY AND TUBULAR PATTERNS OF GROWTH. D. THE GREATEST DIAMETER OF THE NEOPLASM IS 10.5 CM. E. THE NEOPLASM EXTENDS THROUGH THE RENAL CAPSULE WITH MULTIPLE SATELLiTE NODULES, BUT IS CONFINED WITHIN GEROTA FASCIA. F. NO INVASION OF THE RENAL VEIN IS IDENTIFIED. G. ANGIOLYMPHATIC INVASION IS IDENTIFIED. H. All Surgical. maRGinS ARe frEE Of The NneOplAsm. I. THE NON-NEOPLASTIC KIDNEY IS UNREMARKABLE. Y. THE ADRENAL GLAND IS NOT SUBMITTED K. NO LYMPH NODES ARE IDENTIFIED L. TNM STAGE: pT3 NX MX. tNm HIstOLOGiC GRADE = G4. COMMENT: This tumor has an unusal morphology with areas closely resembling clear cel! type carcinoma which are admixed with additiona! more high grade spindle cell components including those with tumor nuclei that are markedly enlarged, with macronuclei, irregular nuclear shapes and pleomorphism. In addition, there are areas with glandular formation, remniscent of an "intestinal" type morphology. Taken together, these are unusual histologica! findings.
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diff --git a/output/text/894d55c0-f02c-4dac-877a-328be4c4561a.txt b/output/text/894d55c0-f02c-4dac-877a-328be4c4561a.txt
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index 0000000000000000000000000000000000000000..19ca2f376cdc7b3fe61dbcb440ec0515c6e23487
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+
+--- Page 1 ---
+FINAL DIAGNOSIS: Collectlon Date: SUPRACERVICAL UTERUS WITH BILATERAL ADNEXA, LAPAROSCOPIC RESECTION - A. CARCINOMA INVOLVING THE CORTEX OF THE LEFT OVARY (see cOmment). B. ENDOMETRIOSIS OF SEROSAL SURFACE OF UTERUS AND LEFT ADNEXA. C. UTERUS WITH SECRETORY ENDOMETRIUM, ENDOCERVICAL CANAL AND LOWER UTERINE SEGMENT WITH NO ABNORMALITIES. D. UNREMARKABLE RIGHT ADNEXA s COMmENT: The carcinoma Involving the surface of the left ovary has the appearance ot the patlent's prior ductal carcinoma of ti1e breast. UUID: 3F499CDC-18A3-44A7-B796-71716F2A2BD2 TCGA-BH-A1FE-06A-PR Redacted +1141 ies-0.3 carcioma,vnfiItnahNg duct, Nss 85ctf3 hw "/4| Sit: ovary C 56.9
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diff --git a/output/text/8977847c-5898-425d-92f2-71a442039ce5.txt b/output/text/8977847c-5898-425d-92f2-71a442039ce5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..efa7536af083a7ae8aa55ced2aa69a3c0485e239
--- /dev/null
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+
+--- Page 1 ---
+UUID: BC78EC6E-73C6-4234-9369-9A5586CD1A69 tcgA-bh-A8Fy-01a-pr Redacted Collection Date: FINAL DIAGNOSIS: Part 1: Left breast, total mastectomy -  A. invasive LOBuLAr CARcinoma up tO 1.8 Cm, nOttingham SCOre 6/9 (tuBuLes 3, nucLear 2,  mitoses 1), nottingham grade 2, Located at the upper outer and Lower outer quadrants. B. EXTENSIVE ATYPICAL LOBULAR HYPERPLASIA AND LOBULAR CARCINOMA IN SITU ADMIXED AND AWAY FROM INVASIVE CARCiNOMA.E C. LYMPhOVASCULAR SPACE inVOLVEMENT NOT SEEN. D.  INVASIVE TUMOR IS 0.4 CM FROM ANTERIOR MARGIN. E.  MARGINS FREE OF TUMOR. F.  MICROSCOPIC FOCUS OF DUCTAL CARCINOMA IN SITU, NUCLEAR GRADE 3, MICROPAPILLARY TYPE, ASSOc!aTed WITh RADiAL SCAr AND ATyPIcal DUCtal ePiTHeLIal hYpErpLASIA. G. CHANGES CONSISTENT WITH BIOPSY SITE. H.  FIBROCYSTIC CHANGES WITH SCLEROSING ADENOSIS. .  Nipple negative for paget's disease. Part 2: Left AxIllA, SenTinel Lymph node #2, Excision - Lymph nODe wITh RAre KERATin POsITiVE CELls (SEe mICROSCOPiC DESCRiptiOn). Part 3: Left axilla, Sentinel lymph node #1, palpable, excision -. ONE LYMPH NODE NEGATIVE FOR TUMOR. COMMENT: There is a microscopic focus of lobular carcinoma in situ with 1.0 mm of invasive carcinoma in soction 1A (section of the nipple). This focus is highlighted by Immunostain, e-cadherin and p120, (see Microscopic Descriptlon). Sentinel lymph node #2 shows rare keratin positive cells . Lymph node #1 (Part 3), is almost complotely replaced by fat. Estrogen / progesterone receptors and HER-2/neu done in the previous core biopsye as follows: ER positive, PR positive, HER-2/neu negative, score 1+..  are reported IcD o :3 CASE SYNOPSIS:  SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST LATERALITY: 8 Left 8520/3 PROCEDURE:  Simple mastectomy Site OYBuss+NoS LOCATION: Upper outer quadrant C50 9 Lower outer quadrant SIZE OF TUMOR:  Maximum dimension invasive component: 18 mm  MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:E Qt u/z4)3 Yes TUMOR AGGREGATE SIZE: Sum of the sizes of rnultiple invasive tumors: 19 mm Tumor Type (invasive component):e  Infiltrating lobular carcinoma HISTOLOGIC TYPE: Classical NOTTInGHAm SCORE: Nuclear grade: 2 Tubule formation: 3 Mitotlc activity score: 1 Total Nottingham score: 6 Nottingham grade (1. 2, 3): 2 ANgIOLYMPHATIC iNVASION: DERMAL LYMPHATIC INVASION: No CALcIFiCATION: No No Tumor type, in situ:  Micropapillary  DCIS present outside of invasive carcinoma component LCIS SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No Distance of invasive tumor to closest margin: 4.0 mm  SURG MARGINS INVOLVED BY IN SITU COMPONENT: No PAGET'S DISEASE OF NIPPLE: Lymph nODes POsITIVe: No Lymph NOdES EXAMinED: 0 mETHOD(S) OF LyMPH NODE EXAMINATION: 2 H/E stain, Keratin stain ONLy KErATin POSITIVE CELLS ArE PRESEnT:  SKIN iNVOLVED (ULCERATION):E Yes No NOn-NeOpLAsTic BReasT Tissue: ADh, ALH, Radial scar t stage, pathologic: N StAge modIfIer: pT1c N stage, pathologic: (sn) pN0(i+) riteria M STAGE: Not applicable Jiagnosis Discrt Estrogen receptors:  PROGESTERONE RECEPTORS: positive IPA positive HER2/NEU: 1+ ua/Snch ase iscirc
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diff --git a/output/text/898ac700-242e-48fb-9a56-bc934040303c.txt b/output/text/898ac700-242e-48fb-9a56-bc934040303c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..876ff8626cc275ce91dd92bdb0e45910a978e452
--- /dev/null
+++ b/output/text/898ac700-242e-48fb-9a56-bc934040303c.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+JCD-0-3 Path: Site: brust. c50.8 IRB APPROVED Clinical Case Report (For Collection of Cancerous Tissue) UUID: 0813A175-83ED-4F6E-AD7D-FB4135CFF34C Criteria TCGA-C8-A1HG-01A-PR Redacted nary Tumor Site Discrepancy I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the IT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Signaturt Date Name of Physician or Study Coordinator Clinical Information S CRQENERAGINFORMATIONNGA Temperature Date of Birth (mm/dd/yyyy) Height. Marital Status Race 1.40m Single Married 37c Gender Weight  Divorced  Widow Blood Pressure Heart Rate Female 48 A2j780 mm(z 83bn  Male EMHISTORYOEPRESENTILLNESST Chief Complaints: 1uunr i, the seght breant. Symptoms: Phut 7nJ n twnwn n, thee kiqht heae+ wru than me yfar. Te arillary ureke ose snalfau Performance Scale (Karnofsky Score):   60-70 Symptomatic, in bed less than 50% of day  100 Asymptomatic  80-90 Symptomatic but Fully Ambulatory 20-30 Bed Ridden  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden RSAAOCURRENTMEDICATIONSSA: Dose Freguency. Date (mm/dd/yyyy) Drug Route To To ND To To To
+
+--- Page 2 ---
+..y.. ..: ....+ ... :. PAST MEDICAL HISTORY : :  Diagnosis Date Status Diagnosis/Disease/Disorder/Injury Treatment Lealh WOBGYNHSTORY Menopausal Status Date of First Menses # of Pregnancles Pre-menopausal yearsolal Date of Last Menses # of Live Births  Peri-Menopausal  Post-menopausal Birth Control:  Condom  Oral Contraceptive  lUD  Hormone Replacement  Other: D0 Therapy: SOCIAL.HISTORY.Pw... Environmental Hazards: Occupation: Smoking History TYPE Packs/day Duration When Quit Current Status 0nO (yrs) (  yes Alcohol Consumption Drinks/day Duration When Quit Current Status TYPE (yrs) (y). O YES Drug Use Frequency Duration When Quit Current Status TYPE (yrs) (yr)  yES tNO NFAMILYMEDICAEHISTORYEMRAA Age of Diagnosis Relative Diagnosis T8 body Waey Caeer TLABDATANE Result Date  Result Date Test Test CEA   Negative  Positive: HIV MNegative  Positive: CA 15-3   Negative  Positive: Hep B Negative  Positive: CA 19-9   Negative  Positive: Hep C   Negative  Positive: PSA  Negative  Positive: AFP  Negative  Positive: Other: Other:  Negative  Positive:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
++++   W  ++DIAGNOSTICSTUDIESi t Study Results Date Ultrasound X-Ray CT Endoscopy MRI Biopsy AMCENICALDIAGNOSIS Preoperative Clinical Diagnosis Reglt bsowt Cauwr Location of Suspected Involved Lymph Nodes Location of Suspected Distant Metastasis Axila NO Clinical Staging Date of Diagnosis T9 M o Stage: Treatment Information .SURGICALTREATMENTE. Procedure Date of Procedure Patey's 'Primary Tumor Organ Detailed Location Size Rseat! 3 x x cm Extension of Tumor N Lymph Nodes Location of Lymph Nodes # of Lymph Nodes Description Palpable, Non-Dissected Lymph Nodes Axill 10 Dissected Lymph Nodes Distant Metastasis Organ Detailed Location Size No Surgical Staging CA T9 No M o Stage: NEOADJUVENTTHERAPYChemoRadiationImmunoHormonal rMolecular Dose Route Frequency Date (mm/dd/yyy) Drug/Treatment 1 To 1 To / / To / / 1 To / / To / 3
+
+--- Page 4 ---
+3 Pathology Form Specimen Information Date: . Collected by: Date Preserved by:- Time: pwwSPECIMENTYPE#of samples proyided* Blood/Serum/Plasma Slide Frozen Paraffin Block Normal Diseased  Normal Diseased  Normal Diseased Normal Diseased + x x Time to Formalin Time to LN2 Time to LN2 min min min SOPATHOLOGICALDESCRIPTION   Primary Tumor Size Extension of Tumor Distance to NAT Organ Rseat 2 xx No 2 cm cm Lymph Nodes # Examined # Metastasized Location N 0 Axilla Distant Metastasis Size Organ Detailed Location ND Pathological Staging No Mo Stage: TA. pT9 Notes: 4
+
+--- Page 5 ---
+cOnsOLIDaTeD DIAgNOstIc pAthoLOgy fOrm* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION Diffuse STRUCTURALPATTERN Streaming Mosaic Necrosis Storiform Lymphocytic Infiltration KFibrosis Vascular Invasion Palisading Cluserized Cystic Degeneration X Alveolar Formation Bleeding Indian File X Myxoid Change A Psammoma/Calcification 2. Cellular features: Squamoys + Adenomatous +. . Sarcomatous Squamoid Cel! + Lymphomatous Glandular cell Round Ce!l Spindle Cell Lare Cell Cell Stratification K Fibroblast Keratin Small Cell Secretion x Osteoblast Desmosome. RS CeIlV/RS Like Intracyt. Vacuole Lipoblast Infiam. Cell Pear! Gland formaticn Myoblast Otherwise Specified: Piasma Cell D,607 sat07 D607 1y607 2. Cellular Differentiatior: Well Moderately Poor Y Nuclear Atypia: Nuckar Appearance Aniso Nucleosis 5 Hyperchromatism N Nucleolar Prominent Muttinucleated Giant Cel! DY Mitotic Activity Neckear Grade Histological Diagnosis:_nh/ toatosy Dut/dil CanAsng, o1, G2 Comments: Dat F FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CONTF
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diff --git a/output/text/89c44bb5-3da6-42aa-8221-2a6719f16084.txt b/output/text/89c44bb5-3da6-42aa-8221-2a6719f16084.txt
new file mode 100644
index 0000000000000000000000000000000000000000..270a49b319d1d71ed195d23d34c70f629f40c1e8
--- /dev/null
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+
+--- Page 1 ---
+Accession Number: Report Status: Amend/Addenda Type: Surgical Pathology Specimen Type: Kidnev resection Procedure Date: Ordering Provide PATIENT: TCGA-CZ-5457 PATHOLOGIC DIAGNOSIS: A.RIGHT KIDNEY,NEPHRECTOMY: RENAL CELL CARCINOMA 13.5 cmclear cellFuhrman grade IV (of IVarising in the right lower pole. The tumor extends into the perirenal adipose tissue. Lymphovascular invasion is identified. Tumor invades the renal parenchyma and renal pelvis and renal sihus. Ureter, renal artery and vein margins are negative for cumor. Colloidal iron is negative in the tumor cells. www Immunohistochemistry performed at Bwh demonstrates the following staining profile in tumor cells: Positive-CDi0,RCC AJCC Classification (6th Edition): T3a Nx MX. The non-ncoplastic kidney will be evaluated by Renal Pathology, and the findings wiil be reported in an addendum. B.REGIONAL LYMPH NODES: Fibroadipose tissue and blood clot. No Jymph nodes are present (the entire specimen was examined). CLINICAL DATA: History: with right kidney nase Operation: Nephrectomy. Operative Findings: None given. clinical Diagnosis: None given. ORGAN/TISSUE SUBMITTED: A/. Right kidney. B/2.Regiona1 lymph nodes. GROSS DESCRIPTION: The specimen is received fresh, in two parts eachlabeled with the patient's name and unit number. Part A,1.Right kidneyconsists of a 1369-g right nephrectomy specimen 27.0x14.0 x8.8 cm including right kidney 18.8x8.0 x 8.0 cm with a in dianeter)and ureter(4.8 x 0.4 cm in diameter. No adrenal gland is grossly identified. The specimen is inked black and bivalved to reveal a tan-to-red to tan-to-yellow focally encapsulated, and hemorrhagic lobulated mass (13.5 x 10.0 x 10.5 cm that is present in the lower pole of the kidney and directly abuts the capsule. The mash is less than 0.1 cn to the ink 4.5 cm to the yein,6.0 cm to the artery and 6.5 cm to the ureter. Upon sectioning, the remainder of the kidney, there are multiple (greater than five) areas of red/brown nodularity (0.3 to i.1 cm in greatest dimension) scattered throughout the renal parenchyma. There is also a large necrotic area (7.2x
+
+--- Page 2 ---
+Accession Number: Report Status: Final Type: Cytogenetics CASE PATIENT: Cytogenetc CGA-CZ-5457 KARYOTYPE: K370-80<4n>xxy-1-3-3-8-8de19p22x2-10-10-14-14add19 q13x2+20-21-21-22-22cp5 ANALYZED:5 SCORED:0 BANDING:GTG METAPHASES COUNTED:5 INTERPRETATION: Four different specimens were received from this tumor. All metaphases from the specimen labeled T3 contained clonal aberrations that included loss of chromosome 3,a characteristic finding in renal cell carcinomaclear cell type. No metaphases were available from the remaining 3 specimens. COMMENTS: Mosaicism and small chromosome anomalies may not be detectable using the standard methods employed. Chromosome analysis was performed at a ievel of 400 bands or greater. INDICATION FOR TEST: Renal Cell Carcinoma
+
+--- Page 3 ---
+auorogyRepor The sample consistsof cortexand medulla. There are two hundred-two (202) glomeruli present, of which 15 (7.4 3) are globally aclerosed the sclerosed glomeruli tend to be grouped in small areas of parenchymal atrophy. remaining glomeruli show significant expansion of the mesangial areas with focal formation of early nodules.There are no discernible craters or double contours of the glomerular capillary wall in the Jones stain. Several distal tubules contain PAs-positive hyaline casts. The interstitium contains a mild Approximately 30 of the cortical parenchyma shows tubular at.rophy and interstitial fibrosis Arteries and arterioles exhibit a moderate degree of sclerosis with hyaline degeneration.
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diff --git a/output/text/8a1894e8-00b7-4ad7-abe7-99b11bfd90c6.txt b/output/text/8a1894e8-00b7-4ad7-abe7-99b11bfd90c6.txt
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index 0000000000000000000000000000000000000000..fd90f07e87449dc33486e3b7bced095081c78c04
--- /dev/null
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+
+--- Page 1 ---
+eD-o-3 C 50.9 JtO 4/z/13 JUID:F2409024-D848-4802-A371 TCGA-AR-A5OP-01A-PR Redacted A. Breast, left, lumpectomy: Infiltrating lobular carcinoma, Nottingham grade I (of III) [tubules 3/3, nuclei 1/3, mitoses 1/3; Nottingham score 5/9], forming a 2.2 x 2.1 x 1.6 cm mass. Angiolymphatic invasion is absent. The non-neoplastic breast parenchyma shows. nonproliferative fibrocystic changes. Biopsy site changes present. All surgical resection margins are negative for tumor (minimum tumor free margin, 0.4 cm, deep margin, and 0.6 cm, anterior. margin). B. Lymph node, left, sentinel biopsy: One (of 2) axillary sentinel lymph nodes is positive with. multiple (5) metastases, the largest measuring 3.5 mm in greatest dimension. Extranodal. extension is focally present. With available surgical material [AJCCpT2N1(sn)], (7th edition, 2010). Seen in consultation with Dua
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diff --git a/output/text/8a5fa934-8091-4520-b426-22c20bdf1e0c.txt b/output/text/8a5fa934-8091-4520-b426-22c20bdf1e0c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e226bbbab64d1529f6eefe6cbe42cc9911bb9483
--- /dev/null
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+
+--- Page 1 ---
+1c0-0-3 Carci ons, mutep(asfc,N0s 851 Sife: bress# Nos C50.9  Final Diagnosis A. Breast, right with axillary sentinel lymph nodes, simple mastectomy: Metaplastic carcinoma, matrix-producing type, Nottingham grade III (of III) is identified forming a 2.7 x 2.3 x 1.7 cm mass in the superior/central region adjacent to a 2.8 x 2.2 x 1.5 cm fibrotic/scarred prior lumpectomy site in the upper inner quadrant. Ductal carcinoma in situ, high nuclear grade with necrosis is focally present. . Angiolymphatic invasion is absent. The non-neoplastic breast parenchyma shows proliferative fibrocystic changes. Biopsy site changes present. The tumor does not involve the nipple, overlying skin, or underlying chest wall. All surgical resection margins, including the deep margin, are negative for tumor (minimum tumor free margin, 3.2 cm, anterior/superior margin). Multiple (5) attached right axillary sentinel lymph nodes, all without blue dye, are negative for metastatic carcinoma. Immunohistochemical cytokeratin stain was performed on the paraffin embedded sentinel lymph node tissue and confirms the H&E impression. B. Lymph node, left axillary sentinel No. 1, biopsy: A single left axillary sentinel lymph node is negative for metastatic carcinoma. Blue dye is identified. C. Lymph node, left axillary sentinel No. 2, biopsy: A single left axillary sentinel lymph node is negative for metastatic carcinoma. Blue dye is identified. D. Breast, right lateral skin flap, excision: Portion of skin and subcutaneous tissue without diagnostic abnormality. E. Breast, left, simple mastectomy: Benign breast parenchyma and nipple. Multiple (3) left axillary sentinel lymph nodes (with blue dye) and a single left axillary lymph node (without blue dye) are negative for metastatic carcinoma. F. Breast, left inferior skin flap, excision: Portion of skin and breast parenchyma. Without diagnostic abnormality. G. Breast, left superior skin flap, excision: Portion of skin and breast parenchyma. Without diagnostic abnormality. H. Breast, left lateral skin flap, excision: Portion of skin and breast parenchyma. Without diagnostic abnormality. UUID:C310F4EC-D8B1-45C4-8D55-705A9EE35902 TCGA-AR-A2LR-01A-PR Reda cted
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diff --git a/output/text/8a73e67b-189d-46b7-9175-666e58309e25.txt b/output/text/8a73e67b-189d-46b7-9175-666e58309e25.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0288d7b3885d2a35f8b3303f99b33fb405d7b707
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+IcA-g-3 Cascuima, infiftnhng duchal, no5 J5oof3 Sitr; breut, N0sC5o.9 1/38/ Pathology Form Corfurm late.shty CqcF =  dotumsntatim Specimen Information Rvn tmu ecR path. Collected by: Date: Time: Preserved by: )Time: Date Frozen Paraffin Block Blood/Serum/Plasma Slide Diseased  Normal Diseased Norma! Diseased Normal Diseased Normal x Time to LN2 Time to Formalin Time to LN2 10 min min min a TN HESPATHOLOGICALDESCRIPTIONAAAW Primary Tumor Organ Size Extension of Tumor  Distance to NAT 2x N 2 cm cm Lymph Nodes Location # Examined # Metastasized Axila Distant Metastasis Organ Detailed Location Size TO Pathological Staging N p m 0 pT2 Stage: A Notes: UUID:8ED8A37B-C885-4333-AC5D-EA73A5A81173 TCGA-C8-A12V-01A-PR Redacted Criteria Diagns Discrepan 4 rimary Tumor Site Discrepancy DISQUALIFIED
+
+--- Page 2 ---
+Microscopic Description wwwwawwwwwww.wwHistologiclPatternwawww.w. Cell Distribution + Structural Pattern + A  Diffuse Streaming  Storiform  Mosaic Fibrosis  Necrosis  Palisading Lymphocytic Infiltration Cystic Degeneration  Vascular Invasion Clusterized  Bleeding Alveolar Formation Myxoid Change Indian File Psammoma/Calcification owohwno CelllarDifferentiationeww.. Adenomatous + Sarcomatous + Lymphomatous Squamous Glandular cell  Round Cell Large Cell  Squamoid Cell  Fibroblast Small Cell Spindle Cell Cell Stratification Osteoblast RS Cell/RS Like  Keratin  Secretion Intracyt. Vacuole  Lipoblast Inflam. Cell Desmosome  Gland formation  Myoblast Plasma Cell  Pear! Wel! Moderate r Poor Cellular Differentiation: wwNuclearAppearancew I II III Nuclear Atypia: 0  Aniso Nucleosis Hyperchromatism ~P  Nucleolar Prominent  Multinucleated Giant Cell  Mitotic Activity f Nuclear Grade: woHcDataca Value Date Marker Result ER Negative  Positive PR  Negative  Positive  Negative  Positive Her-2/neu  Negative  Positive B-Cell Marker T-Cell Marker  Negative  Positive Other:  Negative  Positive .  Negative  Positive Other: Finai Pathology Report Wednll. Cariuma Histological Diagnosis: Grade: 0 Comments: Date Pathologist Principal Investigator A
+
+--- Page 3 ---
+COnsOLIDateD DIagNOsTIC pAThOLOgy fORm* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION Diffuse + STRUCTURAL PATTERNS Mosaic 7Streaming Necrosis Storiform Lymphocytic Infiltration Fibrosis Vascular Invasion  Palisading Clusterized Cystic Degeneration Alveolar Formation Bleeding Indian File Myxoid Change 2. Celluiar features: Psammoma/Calcification Squamous + Adenomatous Squamoid Cell + Sarcomatous + Lymphomatous Glandular cel! Round Cel! Spindle Cell Large Celi Cell Stratification Fibroblast  Keratin Small Cel! Secretion Osteoblast RS CeIVRS Like  Desmosome Intracyt. Vacuole  Lipoblast  Inflam. Cell  Pearl Gland formation Myoblast Plasma Cell Otherwise Specified: D1 7s7 Neegory 2 2. Cellular Differentiation: Well Moderately Nuclear Atypia: Nuclear Appearance Aniso Nucleosis Hyperchromatism Nucleolar Prominent y Multinucleated Giant Cell Mitotic Activity Nuclear Grade AtalCanrng, wos G-3 Histological Diagnosis: I~h(HrAt n. Comments: Date Director, Research Pathologye PATHOLOGIST STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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diff --git a/output/text/8a78eedc-6b33-42fb-975d-5306a42f389f.txt b/output/text/8a78eedc-6b33-42fb-975d-5306a42f389f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..40f931a6274d08be8bdecae1231d9045a6951e55
--- /dev/null
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@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+UUID:6B36ACD0-3F89-4240-8A34-9765FA673403 TCGA-NP-A5H1-01A-PR Redacted Patient: Gender: F Ref#: Hosp#: Patient Location:. Date of Service:. Date Received: FinAl SUrgiCaL pAThOLOgy REpOrt Diagnosis: RIGHT KIDNEy, RADICAL NeEPHrECTOMy: - ChrOmOphObe renal Cell CarcinomA, fuHrman graDe 2. - THE TUmOR IS 3.5 Cm IN DIAmETER. - Tumor iS CONfINed WIThIn KIDney, ABUts The renaL CApSULe, AnD Is prESent at SupeRIOr pOLE. - VaScULAR AnD Ureteral MArgInS free OF TumOR. - NEGATIVE FOR RENAL SINUS INVASION. - ARTERIOLOSCLEROSIS IN NON-TUMOR PORTION OF KIDNEY, COMPATIBLE WITh Patient's hIStOry Of hyperTenSiOn. COMMENT: This case has been reviewed by diagnosis of chromophobe renal cell carcinoma. who concurs with the LcD-o-3 Carcinima, renal cell. 83i7/3 Site: Kidney N6S C64.9 Case #: Page 1 This report continues... (FINAl.)
+
+--- Page 2 ---
+Patient: Case # FINAL SURGICAL PAThOLOGy REPORT Kidney Tumor Staging Information Data derived from current specimen. Staging in accordance with or modified from AJCC Cancer Staging Handbook, 7th Ed, and CAP protocol.. Case # Page 2 This report continues... (FINAL).
+
+--- Page 3 ---
+Pationt Case # Procedure:  Specimen type Radical nephrectomy. Specimen laterality: Kidney resection. Right. TUMOR FEATURES: Tumor size: 3.5 cm. Turmor focality: Histologic type: Unifocal Histologic grade: Chromophobe renal cell carcinoma. Sarcomatoid features: 2, Macroscopic extent of tumor: Absent. Microscopic tumor extension; Confined within kidney abutting renal capsule. Confined within kidney, confined within renal capsule LYMPH NODES None identified. MARGIN EVALUATION Distance to closest margin: Tumor present at least 4.5 cm from vascular margin and ureteral margin. PATHOLOGIC TUMOR STAGING Primary tumor: Regional lymph nodes:. pT1a. Distant metastasis: pNX. Margin status: pMX. Pathologic stage: Negative (R0). I. Pathologic findings in non-neoplastic kidney Arteriolosclerosis, scattered sclerotic glomeruli,  nonspecific mild chronic inflammation. Case #: Page 3 s report continues.. (FINAL)
+
+--- Page 4 ---
+Ipatian. Case # FINAL SUrGICAL PATHOLOGy REPORT Source of Specimen: Kidney;Rignt Clinical History/Operative Dx: Renal mass Gross Description: Single specimen received at this time designated as right kidney. Initially received in a tresh state for  tumor bank studies, is a 598 gram radical nephrectomy with an abundant perinephric fat, 17.5 x 10.2 x 5.6. cm. The adrenal gland is not included. The ureter extends out to 8.0 cm and narrows to 0.3 cm in  diameter with a pinpoint lumen. Initially a palpable mass is not appreciated, and the kidney is bisected, to reveal a well circumscribed, glistening pale tan tumor mass near the upper pole, measuring 3.5 x 3.0 x 2.6. cm. This tumor abuts the anterior and posterior renal capsules. Anteriorly the Gerota's fascia overlies the perinephric fat which extends out to 0.7 cm from the tunor mass (A4, A5), and the posterior fat extends out to 0.6 cm (A6). The mass lesion approaches to within 0.1 cm of the fatty sinuses. A representative portion. of tumor is submitted for tumor bank studies.  The renal vessels extend down 2.5 cm, with the margins greater than 4.5 cm from the tumor mass. The pelvis is 3.0 x 1.8 cm, with glistening light tan mucosa.. without grossly invasive tumor. The cut sections of the kidney demonstrate a distinct cortical medullary  gross tumor involvement and no grossly distinct lymph node tissue candidates. Representative sections are. submitted. Cassette summary: A1) ureter and renal vascular margins, A2) posterior and anterior renal pelvis represented, A3-A5) representation of tumor, renal capsule, Gerota's fascia, A6) tumor, posterior renal capsule and overlying fat, A7) tumor, adjacent renal sinus, A8) uninvolved kidney represented. Microscopic Description: Immunohistochemical stains: Tumor cells positive tor CK7, CD117, PAX-8 and CD10. Tumor cells  negative for Vimentin. The morphologic and immunohistochemical findings are compatible with diagnosis of chromophobe renal cell carcinoma. Appropriate positive and negative immunohistochemical controls have been reviewed. Case t Page 4 REPRINT: Orig. printing on HRMoph
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diff --git a/output/text/8a846354-966b-47ca-9d3f-133937970d7c.txt b/output/text/8a846354-966b-47ca-9d3f-133937970d7c.txt
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index 0000000000000000000000000000000000000000..fae63a5e6be1fd5de81613a08f61e2d2b77fe3f9
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+
+--- Page 1 ---
+UUID:9F0AF874-3063-43F9-A3E7-DBD31337C741 TCGA-L1-A7W4-01A-PR Redacted D c3 Odarocsrcinme) ductNoS 8500/3 Sute Yancuoohead Surgical Pathology Report Cq5.0 Qs 10/s13 DATE OBTAINED: LOCATION: DATE RECEIVED: SUBMITTING MD: DATE REPORTED: CC: DIAGNOSIS 1. FALCIfORm LIGAmeNT; EXCISION: BENIGN fIBrOMUSCULAR AnD ADIpOSE TISSUe; NEgATIVE FOR Tumor. 2. gallbladDer; Cholecystectomy: mild Chronic Cholecystitis; negative for tumor. 3. Pancreas, Stomach and Small bowel; whipple proceDure: PANCREATIC DUCTAL ADENOCARCINOMA Tumor site: Head of pancreas Tumor size: 2.8 cm Histologic type: Ductal Adenocarcinoma with focal non-keratinizing squamous component Per T3S. sGermo Histologic grade: Poorly differentiated Osr. BR Jotals' Microscopic tumor extension: Tumor extends into the peripancreatic tissue and spares the ampulla Margins: Positive superior sott tissue margin; other pancreatic parenchymal margin, negative (see part 5) Negative bile duct margin Positive mesenteric vein margin (SMV) Negative mesenteric artery margin (SMA) Treatment effect: Not identifled Lymph-vascular invasion: Identitied Perineural invasion: Identified Regional lymph nodes: 2/11 lymph nodes positive for metastatic carcinoma, with extranodal extension, largest focus measuring 1.7 cm (includes lymph node in specimen #5) Distant metastasis: Not identified Other tindings: Chronic pancreatitis pTNM: pT3, pN1, pM0 AJCC (2010): Stage IIB 4. portal VeIn; RESectiOn: POsITIve fOr InVasive CARcinomA. 5. PANCREAS; ADDITIONAL MARGIN; RESECTiON: MARGIN NEGATIVE fOR INVASIVE CARCINOMA; ONE Lymph nODe WIth metastaTIC DISeASe (1/1). 6. OmENTUm; OMeNTECTOMy: BENIGN ADIPOSE TiSSUe WITH A fOCAL FIBROTIC AND CALCiFIED NODule; negatIve fOr metastatic Disease. ***Electronically Signed Out*** Page 1 of 3
+
+--- Page 2 ---
+Surgical Pathology Report COMMENT  Intraoperatively, the pancreatic margin shows crushed atypical cells (best seen on FS slides) and tinal pancreatic margin (slide 5A). is negative. 88331x2, 88332x2, 88309, 88304, 88305x4 Clinical Diagnosis and History:. Pancreatic ca Tissue(s) Submitted: 1: FALCIFORM LIGAMENT 2: GALLBLADDER 3: WHIPPLE 4: PROTAL VEIN RESECTION  5: ADDITIONAL PANCREAS MARGIN 6: OMENTUM Gross Description:  Specimen #1 is labeled with the patient name and falciform ligament. Received in formalin is a single piece of glistening piece of  adipose tissue with a moderate amount ot white tibrous tissue measuring 17.3 x 6.4 x 1.8 cm. The specimen is serially sectioned to. reveal yellow, glistening adipose tissue with a single band of fibrous tissue. 1A-1B: two pieces each, muscle and ligament, representative Specimen #2 is labeled with the patient name and gallbladder. Received in formalin is an intact gallbladder measuring 7.8 x 3.5 x 1 cm, with the cystic duct margin having a diameter of 0.4 cm. The serosa is tan-purple and smooth with no visible lesions or defects. The specimen is opened to reveal no luminal contents. The mucosa is red-pink and reticulated. No evidence ot cholesterolosis is appreciated. No choleliths are appreciated. The wall thickness measures 0.4 cm. Representative sections are submitted. 2A: cystic duct margin interrupting the sections of gallbladder 2B: multiple pieces, additional representative sections of gallbladder Specimen #3 is received fresh in the frozen room labeled Whipple and consists of an intact Whipple specimen measuring 27.0 cm. in length. The stomach measures 9.7 x 4.3 cm with the wall thickness of 0.7 cm. The duodenum measures 13 x 4.1 cm with a thickness of 0.4 cm. The pancreas measures 7.3 x 4.1 x 3.2 cm. The pancreas is sectioned to reveal a tumor mass measuring 2.8 x 1.9 x 1 cm. The tumor mass grossly approaches the SMV and anterior and superior margins. The tumor is grossly abutting the surgical margin. The tumor does not appear to be extending to the ampulla. The remaining pancreatic parenchyma is unremarkable. Inspection of the peripancreatic fat reveals three lymph nodes. The largest measuring 1.7 cm in greatest diameter. and is grossly positive tor tumor. The mucosa of the stomach of the stomach is tan-pink and unremarkable. The mucosa of the small bowel exhibits a sharp demarcation at the jejunum between viable and non-viable mucosa with non-viable mucosa being deep red and hemorrhagic and the viable being tan-brown with regular folds. The non-viable region extends approximately 7 cm from the distal margin. No gross masses, lesions or defects are appreciated on any of the mucosal surfaces. Inspection of the greater curvature adipose tissue reveals 10 presumptive lymph nodes. Representative sections are submitted. Summary of sections: 3A: one piece, frozen section of bile duct margin 3B: one piece, frozen section of pancreatic margin 3C: one piece, frozen section ot deep bile duct 3D: two pieces, small bowel margin 3E: two pieces, stomach margin. 3F; two pieces, non-viable small bowel 3G: two pieces, viable small bowel 3H: two pieces, stomach 3I-J: multiple pieces each, one lymph node from greater curvature 3K-L: multiple pieces, one lymph node from greater curvature 3M: four pieces, four presumptive lymph nodes. 3N: four pieces, four presumptive lymph nodes 3O-P: one piece each, representative fat from greater curvature 3Q: one piece, ampulla 3R; anterior margin Page 2 of 3
+
+--- Page 3 ---
+Surgical Pathology Report. 3S-T: one piece superior margin 3U:  one piece SMV margin tumor 3V: one piece SMA margin 3W-Z:  one piece each, representative sections of tumor 3AA-BB: one piece each, representative sections of the uninvolved pancreas with peripancreatic fat. 3CC-EE: multiple pieces each, one lymph node 3FF: multiple pieces, one lymph node 3GG:  multiple pieces, one lymph node, representative and all lymph nodes entirely Specimen #4 is labeled with the patient, portal vein resection. Received in formalin are two fragments of tan-pink tissue with the.  smaller measuring 0.3 x 0.2 x 0.2 cm and the larger measuring 0.7 x 0.6 x 0.4 cm. The specimen is submitted in entirely.. 4A: multiple pieces, portal vein resection, all Specimen #5 is received fresh labeled additional pancreas margin and consists of a single segment of pancreas measuring 2.6 x. 1.5 x 0.8 cm in thickness. The distal most aspect has been submitted for frozen section. The specimen is entirely submitted labeled: 5A: one piece, frozen section remnant 5B: remaining pancreas, all Specimen #6 is labeled with the patient name, omentum. Received in formalin is a segment of yellow, glistening adipose tissue measuring 36.8 x 14.6 x 1.3 cm. The surface of the omentum does not exhibit any gross nodularity. Sectioning of the omentum. reveals a single focus of fat necrosis measuring 0.5 cm in greatest diameter. Summary of sections: 6A-B:  one piece each, area of fat necrosis 6C-E: one piece each, representative sections of omentum, representative. Intraoperative Consult Diagnosis 3AFSDX: NEGATIVE 3B/FSDX: PANCREATIC MARGIN WITH SOME RARE ATYPICAL CELLS CAN NOT EXCLUDE ADENOCARCINOMA 3C/FSDX: ADDITIONAL BILE DUCT NEGATIVE 5A/FSDX: NO INVASIVE CARCINOMA CAN NO1 EXCLUDE PanIN. se is (circle UALIFIED Page 3 of 3 END OF REPORT
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diff --git a/output/text/8b098d24-0a60-42fe-be15-6cb4cdca60a6.txt b/output/text/8b098d24-0a60-42fe-be15-6cb4cdca60a6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1a04f65b86f78793ac37c805995af19b69c56e0e
--- /dev/null
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+taD0 3 8Q60/3 Sute: Xidnuy`Eb4.9 UUID:5E01A3C9-BFCC-4C36-ADA7-43902EFD8A24 Redacted #S 6/13114 1.  Peri-renal fat layer is free of tumor 2. One 4.2 cm in diameter Papillary Renal Cell Carcinoma, Type I without mayor infiltration of lymphnodes , with minimal diffusion to the surgical border of 0.6 cm. pTNM classification version 2002: Malignant Tumor Stage: pT1b, R0 Grade: GII ICD-0-Code: 8260/3 Lateratity =(R lw 5/4/1y
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diff --git a/output/text/8b1f0c8e-7621-4054-b21b-d29be5a6e55d.txt b/output/text/8b1f0c8e-7621-4054-b21b-d29be5a6e55d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..19707d696ca8d9df7fe5cacd381d4aa88fbd477c
--- /dev/null
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+
+--- Page 1 ---
+Clinical Diagnosis & History y/o male with large left renal mass found incidentally.Left radical nephrectomy today. Specimens Submitted: 1:SPkidney.left,radical nephrectomy 2SP:lymph nodes,left periaortic,excision 3:SPlymph nodesleft hilarexcision DIAGNOSIS: 1.SP:kidney,left,radical nephrectomy Tumor Type: Renal cell carcinoma-Chromophobe type Tumor Size: Greatest diameter is 12.5 cm. Local Invasion (for renal cortical types): Involves renal sinus fat Renal Vein Invasion: Not identified Vessels with muscular wall are involved by tumor in the renal sinus Surgical Margins: Free of tumor Non-Neoplastic Kidney: Unremarkable Adrenal Gland: Not identified Lymph Nodes: Not identified Staging for renal cell carcinoma/oncocytoma: pT3a Tumor invades the adrenal gland or perinephric tissues but not beyond Gerota's fascia 2.SP:lymph nodes,left periaortic,excision Lymph Nodes: Number of nodes examined:5 Number of metastatic nodes:0 Page 1of3
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT 3.SP:lymph nodes,left hilar,excision Lymph Nodes: Number of nodes examined:1 Number of metastatic nodes:0 Unremarkable ectopic adrenal tissue IATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THESLIDES (AND/OR OTHER MATERIAL),AND THAT I HAVE REVIEWED ANDAPPROVED THIS REPORT Gross Description: 1). The specimen is received fresh labeled "left kidney" and consists of a kidney with attached ureter,renal vessels and perinephric fat weighing 1100 g in total. The kidney measures 15.0 x 11.0x 7.0 cm. The attached ureter measures 7.0 cm in length and 0.2 cm in diameter.The attached renal vein measures 1.0 cm in length and 0.5 cm in diameter. The renal vessels and ureter margins are grossly unremarkable.An adrenal gland is not identified.The kidney is inked black and bivalved to reveal a 12.5 x 10.0 x 7.0 cm cortical mass located in the mid portion of the kidney.The cut surface of the mass is tan, hemorrhagic and necrotic.The mass invades the Gerota's fascia grossly but does not invade the renal pelvis.Sections through the remainder of the kidney reveal a pink brown parenchyma,with a well-defined corticomedullary junction. The cortex measures 0.5 cm and the calyces appear normal. No lymph nodes identified.Representative sections are submitted for TPS and for permanent sections. Photograph has been taken. Summary of sections: UVM-- ureteral and vessel margins T-tumor THF--tumor with hilar fat TSF--tumor with sinus fat TK-tumor with adjacent kidney U-- ureter representative sections K-- representative sections of kidney TG-tumor with capsule 2).The specimen is received in formalin,labeled "left periaortic lymph node" and consists of multiple pink tan firm lymph nodes ranging from 0.5 to 2.0 cm in greatest dimension.All identified lymph nodes are submitted. Summary of sections: LN- lymph nodes 3).The specimen is received in formalin, labeled left hilar lymph node" and consists of 1.0 x 1.0 x 0.5 cm portion of adipose tissue. No lymph node identified.Entirely submitted. Summary of sections: U-undesignated Summary of Sections: Part1SP kidney, left, radical nephrectomy Page2of3
+
+--- Page 3 ---
+SURGICALPATHOLOGYREPORT Block Sect.Site PCs 27 k 2 t 7 4 tg 4 1 thf 1 2 tk 2 2 tsf 21 1 u 1 uvm 1 Part 2:SP:lymph nodes,left periaortic excisior Block Sect.Site PCs 3 In 3 Part 3:SP:lymph nodes,left hilar,excision Block Sect.Site PCs 1 u 1 Page3of 3 ENDOF REPORT
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diff --git a/output/text/8b446eb8-3673-4ce7-a800-3aac8f0f8c3e.txt b/output/text/8b446eb8-3673-4ce7-a800-3aac8f0f8c3e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6d9f19491ba58c47f02e5a9f6785a900e28c78f4
--- /dev/null
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+
+--- Page 1 ---
+UUID: 39DA362A-CFF2-4A9B-AAC9-963AA207A837 TCGA-DK-A6B0-01A-PR Redacted SURGICAL PATHOLOGY REPORT Patient Name: Accession #: Med. Rec. #: Date of Procedure: DOB: Location: Date of Receipt: Gender: Service:  Urology Date of Report: Ref. Physician: Account #: Patient Address:  Billing Type: INPATIENT Additional Copy to: Ref. Source: Clinical Diagnosis & History: Diagnosed to have a very large bladder tumor. Right side of bladder wall hydroureteronephrosis, right bladder cancer. Specimens Submitted: 1: SP: Ureter, left distal, excision (fs) 2: SP: Ureter, right distal, excision (fs).  3: SP: Urethra margin, distal, excision (fs). 4: SP: Bladder, prostate, seminal vesicles, radical cystoprostatectomy 5: SP: Lymph nodes, left pelvic, excision. DIAGNOSIS: 1. Ureter, left distal, excision (fs) : z0D-O-3 - Benign ureter wall tissue. 2. Ureter, right distal, excision (fs) : 8120/3 - Benign ureter wall tissue C4 7.2 3. Urethra, distal margin, excision (fs) : y 6/8/3 - Benign ureter wall tissue 4. SP: Bladder, prostate, seminal vesicles, radical cystoprostatectomye a. Tumor Type: Invasive urothelial carcinoma, NOS Histologic Grade: High grade Pattern of growth of the Non-Invasive component: Papillary A significant part of non-invasive component consists of low grade papillary carcinoma. Pattern of growth of the Invasive component:. Infiltrating Tumor Multicentricity: Not identified  Bladder Local Invasion:  Deep half of muscularis propria Extravesical Tumor Extension: Ureters uninvolved Urethra uninvolved  Page 1 of 6
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT Vascular Invasion: Not identified supported by immunostains for CD31 and D2-40 Perineural Invasion:. Not identified Surgical Margins: Free of tumor Non-Neoplastic Mucosa: Prior biopsy site changes. Prostate: Other prostatic adenocarcinoma. Seminal Vesicles: Not involved Perivesical Lymph Nodes: Not identified The Pathologic Stage is (AJCC 2002):  pT2b (Invades deep half of muscularis propria) PRO (No involvement of prostate) . Adenocarcinoma Gleason's-Grades Primary Gleason grade:3  Secgndary Gleaspn grade:3 Otat Gleason score;6 Tumor' Location: Involves Right posterior Involves Right anterior Two incidental microscopic foci of adenocarcinoma identified in right anterior apex and right posterior mid measuring 0.5 cm and 0.7 cm respectively. Vascular Invasion: Not Identified Perineural Invasion: Not identified Tumor Multicentricity: Multicentric foci of invasive carcinoma are present High Grade Prostatic Intraepithelial Neoplasia: Not Identified Capsule: Tumor confined to prostate Seminal Vesicles: Not involved Bladder Neck: Not Involved Surgical Margins: Free of tumor Page 2 of 6
+
+--- Page 3 ---
+SURGICAL PATHOLOGY REPORT  Non-Neoplastic Prostate: Exhibits nodular hyperplasia Staging (AJCC 1997):  pT2a (confined to the prostate & capsule, involving one lobe). 5.SP: Lymph nodes, left pelvic, excision. Lymph Nodes: Not involved Number of nodes examined:4  The immunostain for AE1/AE3 supports the diagnosis 6. SP: Lymph nodes, right pelvic, excision. Lymph Nodes: Not involved Number of nodes examined:12 Fragment of benign vas deferens. Note. Selected slides of the case were reviewed with Dr.. who agreed with the interpretation.. i ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Special Studies:e Result Special Stain Comment D2-40 CD31 NEG CONT IMM RECUT AE1:AE3  NEG CONT IMM RECUT Gross Description: 1). The specimen is received fresh for frozen section consultation, labeled "Left distal ureter, freeze end opposite clip" and consists of a portion of ureter measuring 1.2 cm in length and 0.3 cm in diameter. The opposite area to the clip is representatively submitted for frozen section. The remaining tissue is trisected and entirely submitted. Summary of sections: FSC -- frozen section control C-E-clipped end RT-remaining tissue Page 3 of 6
+
+--- Page 4 ---
+SURGICAL PATHOLOGY REPORT 2). The specimen is received fresh for frozen section consultation, labeled "Right distal ureter, freeze end opposite clip" and consists of a portion of ureter measuring 1.3 cm in length and 0.5 cm in diameter. The  area opposite to the clip is representatively submitted for frozen section. The remaining tissue is trisected and entirely submitted. Summary of sections: FSC -- frozen section control C-E-clipped end RT- remaining 3). The specimen is received fresh for frozen section consultation, labeled "Distal urethra margin" and consists of a single pink-tan soft tissue measuring 0.3 x 0.6 x 0.2 cm. Entirely submitted for frozen section. Summary of sections: FSC -- frozen section control 4). The specimen is received fresh, labeled " Bladder, prostate and seminal vesicles". It consists of a radical cystoprostatectomy specimen measuring 18.5 cm from superior to inferior, 12.1 cm laterally and 3.9 cm from anterior to posterior. The bladder measures 8.5 x 8.0 x 3.5 cm, the prostate measures 4.0 x 4.5 x 3.2 cm, the right seminal vesicle measures 3.0 x 1.2 x 1.2 cm, the right vas deferens measures 6.5 x 0.5 x 0.7 cm, the left seminal vesicle measures 3.3 x 1.5 x 1.2 cm and the left vas deferens measures 6.8 x 0.5 x 0.5 cm. The anterior and posterior aspect of the bladder is inked black.. The prostatic urethral margin is  shaved and submitted. The bladder is opened along the anterior midline to reveal a fungating friable red-brown tumor measuring 6.5 x 6.0 x 3.8 cm which is situated within the right lateral and posterior bladder wall. The lesion measures 1.7 cm from the left. orifice and grossly surrounds the right orifice..  Both ureters are probe patent measuring up to 0.2 cm in maximum diameter. The. lesion is sectioned to reveal the tumor that grossly extends into but not through the muscularis propria. Extension to the inked fat is grossly not identified. The remaining bladder mucosa is hemorrhagic and focally ulcerated. Discrete perivesical lymph nodes are grossly not identified. The right prostate is inked green and the left prostate is inked blue. The prostate is serially sectioned to reveal tan-yellow whorled cut surface and no discrete masses or lesions.  Representative sections are submitted including three sections from each prostatic quadrant and transition zone. The specimen is photographed. TPS is submitted. Summary of sections: UM -- urethral margin RUM-- right ureter margin. LUM -- left ureter margin. L-- lesion. RUO -- right ureter orifice. LUO-- left ureter orifice. LP --  left posterior wall. LA -- left anterior wall. RP -- right posterior wall. RA--  right anterior wall. TRI -- trigone. DOM-- dome. perivesical fat. RSV -- right seminal vesicle LSV -- left seminal vesicle RAP -- right apex prostate LA P-- left apex prostate RAM -- right anterior mid prostate RPM -- right posterior mid prostate. LAM -- left anterior mid prostate LPM -- left posterior mid prostate. RAB -- right anterior base prostate RPB -- right posterior base prostate. LAB -- left anterior base prostate. LPB -- left posterior base prostate  Page 4 of 6
+
+--- Page 5 ---
+SURGICAL PATHOLOGY REPORT 5).The specimen is received fresh, labeled "left pelvic lymph nodes" and consists of multiple pink tan firm lymph nodes ranging from 0.7 to 1.8 cm in greatest dimension. All identified lymph nodes are submitted. Summary of sections: LN -- lymph nodes- BLN-- bisected lymph nodes (single lymph node bisected and submitted in two cassettes) 6). The specimen is received fresh, labeled "Right pelvic lymph nodes" and consists of seven pink tan lymph nodes, ranging in. size from 0.5 to 2.9 cm in greatest dimension. Separately received in the container, is a smooth pink-tan tubular segment of tissue measuring 3.5 cm in length and 0.2 cm in diameter. On sectioning, a possible pinpoint lumen and no additional discrete. abnormalities are grossly noted. All the lymph nodes and representative sections of the tubular segment of tissue are submitted. Summary of sections: E - ends of tubular segment C -- center of tubular segment SLN - trisected node BLN - bisected node LN-lymph nodes submitted whole Summary of Sections: Part 1:  SP: Ureter, left distal, excision (fs). Block Sect. Site PCs 1 C-E 1 1 FSC 1 1 RT 1 Part 2: SP: Ureter, right distal, excision(fs) ( Block Sect. Site PCs 1 C-E FSC 1 1 RT 1 Part 3: SP: Urethra margin, distal, excision (fs) Block Sect. Site PCs 1 fsc 1 Part 4:  SP: Bladder, prostate, seminal vesicles, radical cystoprostatectomy Block Sect. Site PCs 1  dom 1 1 f 1 6 6 1 la 1 1 lab 1 1 lam 1 1 lap 1 1 Ip 1 1 Ipb 1 1 Ipm 1 1 Isv 1 1 lum 1 luo 1 1 ra 1 1 rab 1  Page 5 of 6
+
+--- Page 6 ---
+SURGICAL PATHOLOGY REPORT 1 ram 1 rap 1 1 1 rp 1 1 rpb 1 rpm 1 1 rsv 1 1 rum 1 1 ruo 1 1 tri 1 1 um 1 Part 5:SP: Lymph nodes, left pelvic, excision Sect. Site PCs Block 2  bln 22 2  In Part 6:SP: Lymph nodes, right pelvic, excision Sect. Site PCs Block 2 bln 2 1 c 1 e 12 1 2 In 1 sIn 1 Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS:  BENIGN URETER. PERMANENT DIAGNOSIS: SAME 2) FROZEN SECTION DIAGNOSIS:  BEnIgn UreTer.: PERMANENT DIAGNOSIS: SAME 3) FROZEN SECTION DIAGNOSIS: BENIGN. PERMANENT DIAGNOSIS: SAME hw sJsJi3 Page 6 of 6 END OF REPORT
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diff --git a/output/text/8b4efc40-8ea2-4ec7-8e0a-d00131bf9b14.txt b/output/text/8b4efc40-8ea2-4ec7-8e0a-d00131bf9b14.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8b600bdc0fcbc3f03e59d38a6aa1a96297d8c032
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+
+--- Page 1 ---
+UUID:32AE5A1A-703B-43C3-948A-719A90DDACC5 TCGA-HN-A2OB-01A-PR Redacted le Type Tumour Primary Sample Preparation Fresh Frozen 9/14f1 Site of Primary (Event) right breast Site of Tissue Breast Year of Sample Collection 1cs-0-3 Age at Sample Collection (yrs) 45 Cavioma, mnifiltrstag 1obulur, NOs Sample Comments Days to Procedure Date 0 8526/3 Days to Diagnosis 14 Sit: brst,Nss c5U.9 Type of Procedure Surgical resection Site of Primary (Histology) Right breast Bilateral Disease 9/14/1 Tumour Size (cm) 2.7000000000000002 Histology Other Grade/Differentiation Grade X - Unknown.  Pathological T T2 Pathological N N1a Number of Nodes Sampled 5 Number of Nodes Positive 2 Clinical M MO Histology Comments Histologic type: Invasive lobular (e cadherin negative). Modified Scarff Bloom Richardson Grade: 1/3 (2). Total score 4/9.. SBR (Scarff-Bloom-Richardson) score 4 ER Status Positive NOS PR Status Positive NOS HER2 Status Negative Lymph Node Metastases None Documented
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diff --git a/output/text/8b5ca040-9eb5-4b88-835d-dac9497aae3d.txt b/output/text/8b5ca040-9eb5-4b88-835d-dac9497aae3d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2bbf54efde7b35ab7729eb59f117b913b442dde5
--- /dev/null
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+
+--- Page 1 ---
+TSS Patient ID: . Case #: DOB: Sex: Female Ethnicity (Race):. Cancer Sample Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma Date of Procurement. I Anatomic Site: Right Breast Tumor location: Primary Tissue Specification: Tumor Specimen Matrix: Tissue Specimen Format: OCT Container: block Type of Procurenient: surgery Grade: 2 T Stage: 2 N Stage: 1 M Stage: 0 Treatment: none. Treatment Details: n/a. Normal Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw Matrix: Blood Specimen Format: frozen Container: tube Date of Procurement: /co-0-3 carcina, iifiltruHny cuct, nos 85oc/3 Site: breast nos. c50.9 hs 10/21 UUID: 5F626A86-EE85-4005-97C5-9E48D9FA77300 TCGA-AN-A0XV-01A-PR Redacted
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diff --git a/output/text/8bb61127-ebb2-4aa1-ba01-7390f25d839e.txt b/output/text/8bb61127-ebb2-4aa1-ba01-7390f25d839e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..64790553427fc25ba8e86e98f35c45d0f83b7e33
--- /dev/null
+++ b/output/text/8bb61127-ebb2-4aa1-ba01-7390f25d839e.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:9F0036F4-EE91-4A18-B53 Print - TCGA-AC-A2BM-01A-Pr Redacted Page l of 4 Back to LIst TEST: Surgical Patholoav Date & Tlme: REPORT STATUS: Final FAciLITy: Patlent: S1271 Surgical Pathology W s/u SURGICAL PATHOLOGY REPORT See Addendum 1c0-0-3 Patient Name:  Accession # cisci smn,infIfnutxq duct nos 850vf3 Med. Rec. #: Billing Type: Inpatient Site: bruot, NOs c50.9 b 5Ja1 Location: DOB : ...ge: Service: Surgery Gender: F Billing #! Taker Received Reported: Physician(s): Specimen(s) Received A: Left sentinel nodes B: Left sentinel node #2 C: Left breast tissue D: Left axillary contents Pathologic Diagnosis "A" - Left sentinel node: Metastatic carcinoma in one (of one) lymph node. Two foci of metastatic tumor are present, the larger measuring 0.3 cm. The metastatic tumor is confined to the lymph node. "B" Left sentinel lymph node #2: One lymph node negative for malignancy. C. Wort breast' tissue? Histologic Type: t Invasive ductal carcinoma (no.) Modified B-R Grade: 3 Tubular score: 3 Nuclear score: 3 Mitosis score: 3 Tumor Size: Greatest dimension: 2.5 cm Additional dimensions: 1.5 X Regional Lymph Nodes: Number of lymph nodes examined: 13 Number of lymph nodes involved: 1 Metastasis dectected by light microscopy Margins of Invasive Carcinoma: Negative Invasive carcinoma is located: 3 cm away from the deep margin Lymphovascular Invasion: Absent Ductal Carcinoma In Situ: Absent Paget's Disease: Absent Distant Metastasis: Cannot be assessed
+
+--- Page 2 ---
+Print . Page 2 of 4 Microcalcifications: Absent Additional Pathologic Findings: Fibroadenomas Specimen Type:. Mastectomy Specimen Size: Greatest dimension: 28 cm Tumor Laterality: Left Tumor Site: Upper inner quadrant Lower inner quadrant Lymph Node Sampling: Sentinel lymph nodes and axillary dissection Comment : In Part "c", one contiguous lymph node is negative for malignancy. H&E and cytokeratin stains examined. pT2 pN1a pMX "D" Left axillary contents: Ten lymph nodes negative for malignancy. Left axillary contents: ESTROGEN AND PROGESTERONE RECEPTOR SYNOPSIS Estrogen and progesterone receptor immunohistochemistry stains are performed utilizing the 6fl1 (ER) and 1A6 clones (PR) along. with the iview detection kit. The stains are performed on formalin-fixed paraffin-embedded sections. Both special stains have adequate controls.. ESTROGEN RECEPTORS: Infiltrating malignant cells showing positive staining:. 60 PROGESTERONE RECEPTORS: Infiltrating malignant cells showing positive staining:. 10 ESTROGEN RECEPTOR RESULTS: PoSitive. PROGESTERONE RECEPTOR RESULTS:  Positive. Note: Consensus Statement on Adfuvant Therapy for Breast Cancer: Any positive nuclear ER immunostaining is considered a positive. result. These immunohistochemistry reaction patterns were developed and their performance characteristics determined by They have not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of. 1988 (cLiA) as qualified to perform high complexity clinical. laboratory testing. Primary Pathologist: Electronically Signed Out by: Addendum Results from HER2 by FISH: 1.4/Not Amplified Electronically Signed Out by Clinical History Left breast cancer. Intraoperative Consultation A - Left sentinel node: Metastatic cancer. (Microscopic frozen section).
+
+--- Page 3 ---
+Page 3 of 4 B - Left sentinel node #2: Negative. (Microscopic frozen section). Gross Description A - The specimen is received fresh for frozen section labeled "left sentinel node." The specimen consists of a pink-tan lymph node measuring 2.5 x 1.5 x 0.9 cm. The specimen is bisected and entirely frozen in cassette "Fs-A1." B - The specimen is received fresh for frozen section labeled "left sentinel node." The specimen consists of a pink-tan lymph node measuring 3 x 2 x 1.2 cm. The specimen is bisected and entirely frozen in cassette "Fs-B1." C - The specimen is received in formalin and labeled "left breast suture at 6 o'clock." The specimen consists of a mastectomy specimen without axillary tissue measuring 28 x 23.5 x 50 cm and weighing 1559 gm. There is an overlying tan ellipse of skin measuring 22 x 7 cm and showing an eccentric wrinkled brown areola measuring 4.5 x 4.5 cm. Within the center of the areola there is an inverted soft brown nipple measuring 1.1 x 1.1 x 0.9 cm. There are grossly no healed incisions or biopsy sites on the skin surface however the medial edge of the areola is partially stained with blue dye. Attached suture marks the 6 o'clock margin. The deep margin is inked black and the specimen is serially sectioned to reveal an irregular firm tumor between the upper-inner and lower-inner quadrants approximately 1 cm from the nipple measuring 2.5 x 2 x 1.5 cm.  The tumor comes to within 3 cm of the deep margin and within 2 cm of the superficial margin (inked blue). Further sectioning reveals a well-circumscribed nodule within the lower-outer quadrant 3.5 cm from the nipple the deep margin. The remaining specimen consists of lobulated fat interspersed with a large amount of tan-white irregularly-indurated tissue with scattered cysts filled with clear fluid measuring up to 0.4 cm in diameter. A lymph node is identified at the axillary margin measuring 1 x 1 x 0.7 cm. Representative sections are submitted in 12 cassettes. cross-section of nipple, "3-4" - tumor, "5" - superficial and *"11" tissue underlying the nipple stained with blue dye, "12" - bisected lymph node at the axillary margin. D - The specimen is received in formalin and labeled "left axillary contents." The specimen consists of a tan-yellow portion of axillary fatty tissue measuring 8 x 5.5 x 3.5 cm and weighing 53 gm. Sectioning reveals 11 potential lymph nodes ranging from 0.4 to 2.3 cm in greatest dimensions. The lymph nodes are totally submitted in 4 cassettes. Block summary: "1" - i lymph nodes 1 of which is bisected, "2" 2 bisected lymph nodes, "3" - 1 bisected lymph node, "4" - 1 bisected lymph node. Microscopic Description Microscopic examination has been performed on all slides. The pathologic diagnosis encompasses the essential microscopic
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diff --git a/output/text/8bc4d395-0cdb-43a5-98cd-ea829f9aa5a4.txt b/output/text/8bc4d395-0cdb-43a5-98cd-ea829f9aa5a4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d5af4a4f94797e530f75fe6e5ba55d2d0c9c383d
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+1cd-0-3 8 500|3 1810 Pasth CQCF Srte: brst,nsyd c50.9 TSS UUID:19360866-C514-4EE1-ACD7-08873828133E TCGA-E2-A15F-01A-PR Redacted SPECIMENS: A. UPPER OUTER QUADRANT LEFT BREAST B. LEFT BREAST CANCER C. SLN #1 D. SLN #2 E. SLN #3 SPECIMEN(S): A. UPPER OUTER QUADRANT LEFT BREAST B. LEFT BREAST CANCER C. SLN #1 D. SLN #2 E. SLN #3 INTRAOPERATIVE CONSULTATION DIAGNOSIS: A- upper outer quadrant left breast: Lesion 2 mm from posterior margin. B- left breast cancer: Tumor at anterior margin. TPC, TPD, TPE-sentinel lymph node #1, #2, #3: No tumor seen. Diagnoses called by Dr. to Dr. at (C, D, E) and l.A,B GROSS DESCRIPTION: A. UPPER OUTER QUADRANT LEFT BREAST Received fresh labeled with the patient's identification and "upper outer quadrant left breast" is an oriented (single-  anterior, double-lateral) 18 g, 2.5 x 2.5 x 2 cm needle localized lumpectomy with radiograph. Ink code: Anterior-  yellow, posterior-black, medial-green, lateral-red, superior-blue, inferior-orange. Specimen is serially sectioned from Iateral to medial in to 8 slices revealing a 0.5 x 0.4 x 0.3 cm firm fibrous area with hemorrhage that is closest to the posterior margin at 0.2 cm. Representatively submitted: A1: lateral margin, perpendicular sections A2: slice 3, posterior superior A3: slice 4, anterior/superior  A4: slice 4, posterior superior (mass)  A5: slice 4, anterior/inferior A6: slice 6, posterior inferior A7: slice 5, superior (mass) A8: slice 5, inferior A9: slice 6, inferior A10: slice 7, superior A11: slice 7, inferior A12: medial margin, perpendicular sections B. LEFT BREAST CANCER Received fresh labeled with the patient's identification and "left breast cancer" is an oriented (single-anterior, double- lateral) needle localized lumpectomy with radiograph. ink code: Anterior-yellow, posterior-black, medial-green, Iateral-right, superior-blue, inferior-orange. Specimen is serially sectioned from medial to lateral into 7 slices revealing a 1.8 x 1.5 x 1.5 cm firm tan stellate mass that is closest to the anterior margin at less than 0.1 cm. Tissue is procured. Representatively submitted:. B1-B2: medial margin, perpendicular sections  B3: slice 2, anterior/inferior B4: slice 3, mid section  B5: slice 3, anterior/inferior B6: slice 4, anterior/superior (mass) B7: slice 4, posterior superior  B8: slice 4, anterior/inferior  B9: slice 4, posterior inferior B10: slice 5, anterior/superior (mass) B11: slice 5, posterior superior B12: slice 5, anterior-inferior (mass)  B13: slice 5, posterior inferior B14: slice 6, anterior/inferior B15: lateral margin, perpendicular sections C. SLN #1
+
+--- Page 2 ---
+Received fresh labeled with the patient's identification and "SLN #1" is a 2 x 1.5 x 1 cm piece of adipose tissue. containing a 1.5-cm lymph node. It is sectioned and a touch prep is performed; lymph node is submitted entirely in cassette C1. D. SLN #2  Received fresh labeled with the patient's identification and "SLN #2" is a 1.5 x 1 x 0.3 cm piece of adipose tissue containing a 0.5-cm lymph node. A touch prep is performed in the lymph node is submitted entirely in cassette D1. E. SLN #3 Received fresh labeled with the patient's identification and "SLN #3" is a 2 x 2 x 1 cm piece of adipose tissue containing a 2-cm lymph node. Specimen is sectioned, touch prep is performed, submitted entirely in cassette E1. DIAGNOSIS: A. BREAST, LEFt OUTER QUADRANT: - BREAST TISSUE - RADIAL SCAR - PREVIOUS BIOPSY SITE.  - NO MALIGNANCY IS SEEN B. BREAST, LEFT, EXCISION: : INVASIVE DUCTAL CARCINOMA, SBR GRADE II, MEASURING 0.5-CM. - DUCTAL CARCINOMA-IN-SITU NUCLEAR GRADE 2/3, SOLID TYPE. - LYMPHOVASCULAR INVASION IS SEEN. - TUMOR IS VERY CLOSE TO THE ANTERIOR MARGIN (<1 MM). - PREVIOUS BIOPSY SITE CHANGES SEE SYNOPTIC REPORT. C. LYMPH NODE, SENTINEL #1, LEFT AXILLA, EXCISION: - ONE REACTIVE LYMPH NODE. - NEGATIVE FOR METASTATIC CARCINOMA (0/1). D. LYMPH NODE, SENTINEL #1, LEFT AXILLA, EXCISION: - ONE REACTIVE LYMPH NODE. - NEGATIVE FOR METASTATIC CARCINOMA (O/1) E. LYMPH NODE, SENTINEL #1, LEFT AXILLA, EXCISION: - ONE REACTIVE LYMPH NODE. - NEGATIVE FOR METASTATIC CARCINOMA (O/1). SYNOPTIC REPORT - BREAST Specimens Involved Specimens:  B: LEFT BREAST CANCER Specimen Type: Excision Needle Localization: Yes - For mass Laterality: Left Invasive Tumor: Present Multifocality: WHO CLASSIFICATION Invasive ductal carcinoma, NOs 8500/3 Tumor size: 1.8cm Additional dimensions:. 1.5cm x 1.5cm Tumor Site:  Upper outer quadrant Margins: Negative Distance from closest margin: Less than 0.1cm anterior Tubular Score: 3 Nuclear Grade: 2 Mitotic Score: 1 Modified Scarff Bloom Richardson Grade: 2 Vascular/Lymphatic invasion: Present Lobular neoplasia:  None Lymph nodes: Sentinel lymph node only Lymph node status: Negative 0/3 DCIS present Margins uninvolved by DCIS. DCIS Quantity:Estimate 5% DCIS Type: Solid DCIS Location:Associated with invasive tumor Nuclear grade: Low
+
+--- Page 3 ---
+Necrosis: Absent ER/PR/HER2 Resuits ER: Positive PR: Positive HER2: Negative Performed on Case: outside core biopsy. Pathological staging (pTN): pT 1c N 0 CLINICAL HISTORY: 1) upper outer quadrant radial scar by core biopsy 2) 12 o'clock invasive cancer Pre-OPErAtIve DIAgnOSIS: Left breast cancer ADDENDUM: ONCOTYPE DX BREAST CANCER ASSAY RESULTS: Recurrence Score: 7 CLINICAL EXPERIENCE: Patients with a recurrence score of: 7 in the clinical validation study had an average  rate of Distant Recurrence at 10 years of 6% ER Score: 11.4  Positive PR Score: 9.7 Positive Her2 Score: 8.9  Negative Interpretation: ER Negative < 6.5 Positive >= 6.5 PR Negative < 5.5 Positive >= 5.5 Her2 Negative <10.7  Positive >=11.5 Equivocal = 10.7 - 11.4 See separate report for further information. Test performed at: The maximum tumor size from the gross description and all slides of the tumor is 1.8cm, The smaller measurement 0.5cm in the diagnosis refers to a partial tumor measurement from a representative slide of the tumor. The maximum tumor size 1.8cm is the total final measurement used for the cancer staging in this case. The stage remains unchanged pT1c pNO Case discussed with Dr. Microscopic/Diagnostic Dictation: Patholoaist. Final Review: Pathologist Final: Pathologist, Addendum: Pathologist,  Addendum Final: Pathologist, Addendum: Pathologist, Addendum Final: Patholuyist,
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diff --git a/output/text/8bd1b49d-6893-4add-88f2-959eacb1eb8f.txt b/output/text/8bd1b49d-6893-4add-88f2-959eacb1eb8f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..61f8571366d0b2cc7e85ad05aa6ad3335d80b8de
--- /dev/null
+++ b/output/text/8bd1b49d-6893-4add-88f2-959eacb1eb8f.txt
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+
+--- Page 1 ---
+TCGA-A6-2676 SPECIMEN Terminal ileum, right colon with attached small bowel and right ovary CLINICAL NOTES PRE-OP DIAGNosIs: Ascending colon mass. GROSS DESCRIPTION Received fresh for tissue procurement labeled "terminal. ileum, right colon with attached small bowel and right ovary" is a previously unopened 35 cm. segment of proximal right colon with attached 50 cm. of distal ileum, an additional 10 cm. of adhesed small bowel and cerebriform 2.7 x 1.0 x 0.8 cm.. rubbery tan gold ovary with associated 2.2 cm. fimbriated tubal segment. A minimal amount of unremarkable omentum is present in addition to a moderate amount of mesocolon and mesentery. The serosa is smooth to scabrous tan pink-purple. The proximal and distal margins measure 3.7 and 6.2 cm. in circumference respectively. On opening there is a necrotic 12.5 x 9.5 cm. circumferential white pink-red tumor mass at the ileocecal valve involving both the distal ileum and proximal. cecum. A portion of tumor is procured as requested. On sectioning, there is a maximal thickness of 3.5 cm. grossly descending through the muscularis into the attached mesocolon and extending to within less than 0.1 cm. of the inked free radial serosal surface (surface of the attached mesocolon inked orange and surface of free serosal surface inked black). In addition, the tumor extends through the wall of the colon and that of the attached additional segment of small bowel to within 0.15 cm. of the mucosal surface of the additional segment. The uninvolved ileal and colonic mucosa is unremarkable glistening tan pink with regular folds and the walls average 0.5 cm. in thickness. No additional mass lesion or abnormality is identified. No appendix is present. The. aforementioned ovary and tubal segment is not involved by tumor, associated with the specimen solely by adhesions. The ?? is GROSS DESCRIPTION pale tan with identifiable corpora albicantia. Several soft to slightly rubbery pale tan tissues in keeping with lymph nodes measuring up to 1.4 cm. in greatest dimension are recovered from the. attached mesocolon and mesentery. Representative sections are submitted in 15 blocks as labeled. BLOCK suMMARy: 1 - Margin; 2 and 3 - tumor full thickness through. mesocolon to surface of mesocolon (inked orange; point of continuity. inked red); 4 and 5 - tumor full thickness to inked free radial serosal surface; 6 - tumor full thickness to attached additional small bowel segment; 7 - IcB; 8 - tumor to normal ileum and normal colon; 9 - random ileum; 10 - random colon; 11 - adhesed ovary and tube segment; 12 and 13 - eight whole lymph nodes per cassette; 14. and 15 - one bisected lymph per cassette.
+
+--- Page 2 ---
+MICROSCOPIC DESCRIPTION Histologic type:  Adenocarcinoma with focal mucinous differentiation. Histologic grade: Poorly differentiated. Primary tumor (pT): Tumor has extended through the wall of the colon into the wall of the adjacent small intestine (pT4). Proximal margin: Negative. Distal margin: Negative. Circumferential (radial) margin: Negative. Vascular invasion: Negative. Regional lymph nodes (pN): Fifteen mesenteric lymph nodes are free of metastatic carcinoma (pNo). Non-lymph node pericolonic tumor: Absent. Distant metastasis (pM): Cannot be assessed (pmx). Other findings: Right ovary and fallopian tube adhesed to the colon without evidence of involvement by tumor. MICROSCOPIC DESCRIPTION 5, 3 DIAGNOSIS Terminal ileum right colon with attached small bowel and right ovary and fallopian tube, en bloc resection: Invasive poorly differentiated colonic adenocarcinoma with focal mucinous differentiation extending through the wall of the colon. into the wall of the adhesed small bowel segment. Tumor also extends across the ileocecal valve into the terminal ileum. Proximal, distal and radial margins of resection are free. of tumor.. Fifteen mesenteric lymph nodes without evidence of metastatic. carcinoma (0/15). Adhesed right fallopian tube and ovary without evidence of. involvement by tumor.
+
+--- Page 3 ---
+MICROSCOPIC DESCRIPTION Histologic type: Adenocarcinoma with focal mucinous differentiation. Histologic grade: Poorly differentiated.. Primary tumor (pT):. Tumor has extended through the wall of the. Proximal margin: Negative.. Distal margin: Negative. Circumferential (radial) margin: Negative. Vascular invasion: Negative. Regional lymph nodes (pN): Fifteen mesenteric lymph nodes are free of metastatic carcinoma (pno). Non-lymph node pericolonic tumor: Absent. Distant metastasis (pM): Cannot be assessed (pmx).. Other findings: Right ovary and fallopian tube adhesed to the colon without evidence of involvement by tumor.. MICROSCOPIC DESCRIPTIONS 5, 3 DIAGNOSIS Terminal ileum right colon with attached small bowel and right ovary and fallopian tube, en bloc resection: Invasive poorly differentiated colonic adenocarcinoma with focal mucinous differentiation extending through the wall of the colon into the wall of the adhesed small bowel segment.. Tumor also extends across the ileocecal valve into the terminal ileum. Proximal, distal and radial margins of resection are free of tumor. Fifteen mesenteric lymph nodes without evidence of metastatic carcinoma (0/15). Adhesed right fallopian tube and ovary without evidence of involvement by tumor..
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diff --git a/output/text/8c3b0ca6-38b7-47bc-b64a-c048cc6f3956.txt b/output/text/8c3b0ca6-38b7-47bc-b64a-c048cc6f3956.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c999064c4fc56bc90c6c8a1a4b3b7e8e1b15abfe
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+--- Page 1 ---
+Carinena, bnfiltratin, dut, Nos Tss: 85ot|3 SiteOdu: brist, Nos ( 50.q TSS: UUID:4E233F7D-035A-44A0-A5B6-6248357EB7820 TCGA-E2-A1AZ-01A-PR Redacted SPECIMENS: A. SENTINEL LMYPH NODE LEFT AXILLA #1 B. SLNODE LEFT AXILLA 2 C. SLNODE 3 D. WIDE EXCISION LEFT BREAST E. ADDITIONAL DEEP MARGIN F. ADDITIONAL MEDiIAL MARGIN DIAGNOSIS: A. LYMPH NODE, SENTINEL #1, LEFT AXILLARY, RESECTION: -MICROMETASTATIC CARCINOMA TO ONE OF ONE LYMPH NODE (1/1). B. LYMPH NODE, SENTINEL #2, LEFT AXILLARY, RESECTION: -ONE LYMPH NODE, NEGATIVE FOR METASTASIS (0/1). C. LYMPH NODE, SENTINEL #3, LEFT AXILLARY, RESECTION: -ONE LYMPH NODE, NEGATIVE FOR METASTASIS (0/1) D. BREAST/LEFT, RESECTION: INVASIVE DUCTAL CARCINOMA, SBR GRADE III/II. -TUMOR SIZE: 3.3x2.6x2.5 CM. -MARGINS FREE OF TUMOR. -SEE TEMPLATE. FIBROCYSTIC CHANGES WITH APOCRINE METAPLASiA, SCLEROSING AND BLUNT DUCT ADENOSIS E.  BREAST, ADDITIONAL DEEP MARGIN, RESECTION: -BREAST TISSUE, NEGATIVE FOR TUMOR. BREAST, ADDITIONAL MEDIAL MARGINS, RESECTION: -BENIGN BREAST TISSUE WITH SCLEROSING ADENOSIS AND FOCAL ATYPICAL DUCTAL HYPERPLASIA Invasive Breast Cancer Template INVASIVE TUMOR: Histologic type: Ductal Tumor Size : 3.3x2.6x2.5 cm Size of Invasive Focus: 3.3x2.6x2.5 cm Grade, Histologic: 3 Grade, Nuclear: 3 Mitoses : Scarff Bloom Richardson grade: I! Necrosis: present Invasion Vasc/Lymphatic: DCIS component present DCIS Quantity: <25% DCIS Type: solid DCIS Location: Inside main mass. Nuclear grade: high Necrosis: absent Margins: Negative Lymph nodes:  Positive (1/3) Micrometastases: Yes Extranodal extension: no. Stage, Pathology : pT2N1a (see below) Non-neoplastic areas: Fibrocystic changes with sclerosing and blunt duct adenosis.
+
+--- Page 2 ---
+tSs: Hormone receptor status & HERCEPTEST: Previously done, SPECIMEN(S): A. SENTINEL LMYPH NODE LEFT AXILLA #1 B. SLNODE LEFT AXILLA 2 C. SLNODE 3 D. WIDE EXCISION LEFT BREAST E. ADDITIONAL DEEP MARGIN F. ADDITIONAL MEDIAL MARGIN CLINICAL HIStORy:E Jear old with left breast ca.. FROZEN SECTION DIAGNOSIS: A. SENTINEL LYMPH NODE LEFT AXILLA #1 Touch Prep: Negative by Dr., called to Dr at. B. SENTINEL LYMPH NODE LEFT AXILLA #2 Touch Prep: Negative by Dr., called to Dr a1 C. SENTINEL LYMPH NODE #3 Touch Prep: Negative by Dr., called to Dr. a GROSS DESCRIptIOn: A.  SENTiNEL LYMPH NODE LEFT AXILLA#1 Received fresh is a 1.8x0.9x0.8cm. lymph node. The lymph node is bisected to reveal tan pink. homogenous cut surface. Touch preparation is made. The specimen is submitted in toto in one. cassette. B.  SENTINEL LYMPH NODE LEFT AXILLA #2 Received fresh are two pieces of tan pink soft tissue measuring 0.4x0.4x0.3cm. each. One of them is recognized as lymph node which is bisected. Touch preparations are made. The specimen is submitted in toto in one cassette. C.  SENT!NEL LYMPH NODE #3 Received fresh is one lymph node measuring 1.3x0.8x0.3cm. It is bisected. Touch preparations are made. The specimen is submitted in toto in one cassette. D. WIDE EXCISION LEFT BREAST Received fresh is an oriented portion of firm breast tissue measuring 7.5x7x4.5cm. The specimen is inked and sectioned to reveal a 3.3x2.6x2.5cm. white firm tumor mass, located 0.5cm. from the posterior margin, 1.5cm. from superior margin, 0.4cm. from the medial margin, 0.7cm. from the inferior margin. One section from the tumor is submitted for tissue procurement. A separate white nodule measuring 0.3cm. in diameter is located 1.2cm. from the main tumor mass. This nodule is 1.1cm. from the medial margin. Representative sections are submitted as follows: D1-D4: tumor mass with adjacent margin, representative D5: separate nodule in toto. D6-D9: representative sections from normal looking breast tissue E. ADDITIONAL DEEP MARGIN Received in formalin is an unoriented portion of breast tissue measuring 2.2x2.5x1.5cm. The specimen is inked and serially sectioned to reveal tan yellow lobulated cut surface. No gross lesion is identified. Representatives are submitted in two cassettes.  ADDITIONAL MEDIAL MARGIN Received in formalin is one fragment of tan yellow to pink soft to firm tissue measuring 2.7x2x1.5cm. The specimen is inked and serially sectioned to reveal tan fibrotic cut surface. No gross lesion is identified. The specimen is submitted in toto in two cassettes. Gross Dictation: Pathologist.  Microscopic/Diagnostic Dictation: Pathologist, Microscopic/Diagnostic Dictation: Pathologist, Final Review: Pathologist, Final: Pathologist,.
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diff --git a/output/text/8c4c3029-be76-4f1e-994f-08b590b2546a.txt b/output/text/8c4c3029-be76-4f1e-994f-08b590b2546a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6a08b3993ce1db3bc373d163fa2b6d59628c7115
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+--- Page 1 ---
+UUID:64D079FF-A6FF-4F54-BEE0-E58F8C2BD0D4 TCGA-IB-A6UF-01A-PR Redacted Page I of 4 CONFIDENTIAL SURGICAL PATHOLOgY REPORT Time Collected Time Received Time Reported Time Transmitted Order Number Ordering Provider Status Final Relevant Information IcD O-3uqS Location Copied To Report Patient Demographics (for verification purposes) QpS 7/22/13 Sex: M SUrGICAL PATHOLOgy REpORt +****Surgical Pathology Report***** Accession Number Collected Date/Time Received Date/Time Pathologist Specimen Description. A Omentum at B. Gallbladder at C. Portal lymph node at. D. Whipple specimen at Clinical Information Mass in the head of pancreas Diagnosis A. Omentum: Unremarkable omental fat. Negative for malignancy. B. Gallbladder: Cholelithiasis. Mild chronic cholecystitis.. Reactive cystic duct lymph nodes (x 2). Negative for malignancy or dysplasia. C. Portal Lymph Node:. One reactive lymph node, negative for malignancy. D. Pancreas and Duodenum, Whipple Procedure: Invasive moderately differentiated ductal carcinoma of pancre (within the head). Tumor encased common bile duct and caused common bile duct obstruction. Tumor infiltrated into peripancreatic fat. Extensive perineural invasion. Positive for lymphatic invasion. No angiovascular invasion identified.
+
+--- Page 2 ---
+Page 2 of 4 Vascular bed margin involved by tumor.. Pancreatic uncinate margin involved by tumor.. Pancreatic distal transection margin 0.3 cm away from tumor.. Seven of thirteen peripancreatic lymph nodes positive for metastatic carcinoma (7/17). Five periduodenal lymph nodes all negative for metastatic. carcinoma. Duodenal mucosa not involved by tumor.. pT3N1Mx. See Synoptic report. Reported by: Electronically sianed Verified: Synoptic Report D: Pancreas (Exocrine), Macroscopic SPECIMEN: Head of pancreas PROCEDURE: Pancreaticoduodenectomy (Whipple resection), partial pancreatectomy TUMOR SITE: Pancreatic head Uncinate process TUMOR SIZE: Greatest dimension: 3.3 cm D: Pancreas (Exocrine), Microscopic HISTOLOGIC TYPE: Ductal adenocarcinoma HISTOLOGIC GRADE: G2 :  Moderately differentiated MICROSCOPIC TUMOR EXTENSION: Tumor invades peripancreatic soft tissues. MARGINS : Margin(s) involved by invasive carcinoma Uncinate process (retroperitoneal) margin (nonperitonealized surface of the uncinate process) Invasive carcinoma involves posterior retroperitoneal surface of pancreas TREATMENT EFrecr (applicable to carcinomas treated with neoadjuvant therapy): Not known LYMPH-VASCULAR INVASION: Present PERINEURAL INVASION: Present PRIMARY TUMOR (pT): pT3: Tumor extends beyond the pancreas but without involvement of the celiac axis or the superior mesenteric artery REGIONAL LYMPH NODES (pN) : pN1: Regional lymph node metastasis DISTANT METASTASIS (pM) : Not applicable Gross Description Received are specimen containers A to D..  All requisitions and specimen containers are. labelled with the patient's name,.  The cassettes and are labelled with the A. The specimen is received fresh and is subsequently placed into formalin. container is designated " Omentum". It consists of a piece of omental fat, measuring 37.0
+
+--- Page 3 ---
+Page 3 of 4 x 20.0 x 2.0 cm. No nodules or lymph nodes are revealed. Representative sections are submitted in four cassettes. B. The specimen is received fresh and is subsequently placed into formalin. The container is designated as " Gallbladder". It consists of an intact cholecystectomy greatest dimensions. are attached. Upon opening, seventeen pieces of black gallstones are retrieved, 0.4 to 1.s cm in greatest dimensions. Otherwise the cystic mucosa appears slightly rough, but no mass lesion identified. The cystic wall measures o.15 cm in maximum thickness. The cystic duct is patent. Representative sections are submitted in cassettes labelled as follows:. B1. cross section of cystic duct and representative sections of cystic body and fundus B2. one trisected cystic duct lymph node B3. one bisected cystic duct lymph node C. Specimen is received in formalin. The container is designated " Portal lymph node". It consists of a piece of fibroadipose tissue, 2.3 x 1.5 x 0.8 cm, with a putative lymph node. The specimen is bisected and submitted entirely in two cassettes.. D. The specimen is received fresh and is subsequently placed into formalin. The container is designated " Whipple specimen". It consists of a partial pancreaticoduodenectomy specimen, including a large portion of duodenum and a portion of gastric pylorus, 22.0 cm in length and 7.5 cm in maximum circumference, and a portion of pancreas attached. duodenal mucosa appears unremarkable, and the ampullary region appears slightly The prominent, otherwise unremarkable. The portion of pancreas, measures 6.5 x 5.5 x 3.0 cm. A portion of common bile duct is identified, 5.5 cm in length and 2.2 cm in the maximum circumference at proximal resection margin. The middle portion of the common bile duct appears narrowed, 0.5 cm in diameter. The proximal portion of common bile duct mucosa appears to be denuded..  The tissue surrounding the common bile duct appears fibrotic. likely involved by tumor. The pancreatic resection margin is inked in blue, the vascular bed margin inked in green, and the uncinate through the pancreas reveal a ill-defined, firm mass, 3.3 cm in maximum dimension. On cut changes. Grossly, the tumor appears to be less than 1.0 mm from the pancreatic resection margin. less than 0.1 cm from the vascular bed margin, and o.5 cm from the uncinate  margin. Multiple peripancreatic lymph nodes are retrieved. Representative sections are submitted in cassettes labelled as follows: D1. shaved proximal resection margin of common bile duct D2. proximal margin of duodenal/pylorus D3. distal resection margin of duodenum D4. a cross section through the mid of common bile duct and underlying tumor. D5. peripancreatic lymph node next to D4 D6 to 8. remaining sections of the lymph node in D5 D9/10. additional cross sections through common bile duct and tumor Dil. a cross section through tumor and vascular bed margin D12. tumor with uncinate margin D13. cross section of tumor through resection margin D14/15. a single cross section of tumor with resection margin, vascular margin and uncinate margin D16/17. a single cross section of tumor with uncinate, resection, and vascular bed margins D18. cross section of uncinate margin with underlying fat (including area of suspected fat. necrosis) D19. additional section of vascular bed margin with tumor D20. one bisected peripancreatic lymph node
+
+--- Page 4 ---
+Page 4 of 4 D21. tumor with overlying duodenal mucosa. D22. representative section with duodenal with underlying unremarkable pancreas D23. one bisected periduodenal lymph node. D24. one bisected periduodenal lymph node. D25. two periduodenal lymph nodes D26. one periduodenal lymph node. Accession Number Encounter Number Patient Location 4
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diff --git a/output/text/8cce036a-379d-4d6c-8cac-da7b1458d0c2.txt b/output/text/8cce036a-379d-4d6c-8cac-da7b1458d0c2.txt
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index 0000000000000000000000000000000000000000..e4c8cb038860cca92dca145149a2be8c05069a9d
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+ UUID:5CDCBD3A-060E-4F28-9328-F136788572F1 TCGA-Q2-A5QZ-01A-PR Redacted MEDICAL CENTER LABORATORY PAGE:1 Spocimen Inquiry ACCT #: LOC: U# : PATIENT : AGE/SX: IE SPEC #: CLINICAL HISTORY: RIGHT RENAL MASS SPECIMEN/PROCEDURE : 1. KIDNEY - RIGHT IMPRESSION: RIGHT KIDNEY, RIGHT NEPHRECTOMY: Papillary renal cell carcinoma, type II, Fuhrman nuclear grade 3, with focal renal capsule invasion. (Please see tumor checklist). Margins of resection, free of tumor.. Icd-o-3 KIDNEY: NEPHRECTOMY,  PARTIAL OR RADICAL CASE SUMMARY 82b0|3 PROCEDURE 5;te R Kidney NsS Radical nephrectomy C64.9 SPECIMEN LATERALITY 4/12/3 Right TUMOR SITE Middle TUMoR SIzE (largest tumor if multiple) Greatest dimension: 5.3 cm Additional dimensions: 5.2 x 4.8 cm TUMOR FOCALITY Unifocal MACROSCOPIC EXTENT OF TUMOR Tumor abutting the renal capsule with possible. extension into perinephric tissue (beyond. capsule) HISTOLOGIC TYPE Papillary renal cell carcinoma SARCOMATOID FEATURES Not identified TUMOR NECROSIS (any amount) Present HISTOLOGIC GRADE (FUHRMAN NUCLEAR GRADE) G3: Nuclei very irregular, approximately 20  m; nucleoli large and prominent CONTINUED ON NEXT PAGE **
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+(Continued) Page: 2 SPEC #: IMPRESSION: (continued) MICROSCOPIC TUMOR EXTENSION Tumor extension into perinephric tissue (beyond renal capsule) MARGINS Margins uninvolved by invasive carcinoma. LYMPH-VASCULAR INVASION vena cava (excluding renal vein and its muscle containing segmental branches and inferior Absent PATHOLOGIC STAGING (pTNM) PRIMARY TUMOR (pT) invade: renal and/or renal sinus fat but not beyond Gerota's fascia pT3a: Tumox REGIONAL LYMPH NODES (pN) No nodes submitted or found DISTANT METASTASIS (pM) Not applicable PATHOLOGIC FINDINGS IN NONNEOPLASTIC KIDNEY Significant pathologic alterations. Tubulointerstitial disease (specify type): Chronic interstitial nephritis pT3a NX M Pathologic TNM (AJcc 7th edition): COMMENT : Case reviewed by SPECIAL STAINS/PROCEDURES: Inmunohistochemical stains were performed with appropriate positive and negative controls. Pancytokeratin: Positive in tumor cells with likely perinephric tissue invasion. CD31: No difinite evidence of intravascular tumor invasion seen. GROSS DESCRIPTION: 1. Received fresh, labeled with the patient's name, medical record number and "right kidney" is a 302 gram right radical nephrectomy specimen including kidney (9.5 x 7.8 x 6.8 cm) and surrounding perirenal fat measuring in thickness from 1.0 to 2.0 cm. No adrenal gland is identified. Extending from the renal pelvis is a ureter (2.5 cm in length by 0.3 cm in diameter), renal vein (0.5 cm in length by 0.3 cm in diameter), and renal artery (1 cm in diameter by 0.4 cm in diameter). There is a 5.3 x 5.2 x 4.8 cm pale-white tumor with ** CONTINUED ON NEXT PAGE **
+
+--- Page 3 ---
+SPEC #: (Continued) Page: 3 GROSS DEsCRIpTIoN: (continued) perirenal fat without penetrating the renal capsule. The tumor also does not involve renal sinus fat or the renal pelvis. The remainder of the renal cortex is tan/brown with a well-defined cortical medullary junction. The pelvis and calyces are covered by smooth glistening mucosa. The adipose tissue is thinly sectioned and no lymphnodes are identified. A portion of the tumor is taken for TcgA research.. Devitalization time: Freeze time:. Ink code: black-outer surface of specimen. CASSETTE SUMMARY: CASSETTE 1A: renal artery, vein and ureter CAssetTE 1b-1e: tumor abutting perirenal fat CASSeTTE 1G, 1H: tumor adjacent to renal sinus\ CASSETTE 1J: tumor with kidney parenchyma CASSETTE 1K: normal kidney CASSETTE 1L, 1M: additional sections of tumor with kidney parenchyma. Entered COPIES TO: Cpt Codes: IHC CD31-88342, KIDNEY, PART/TTL RESECTION TUMOR/883O7, IHC KERATIN COCKTAIL-88342, NEG MAB CONTROL/2 ICD9 Codes: 189.0 Resident Physician:. I have personally reviewed the material (specimen/slide) and approve this final report.. Electronically Signed by: Physicians *+ END OF REPORT ** 3 QUALIFIED DISOLA ate Reviewe33
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diff --git a/output/text/8cd36276-1e5a-44c0-be92-12b4c31a7aca.txt b/output/text/8cd36276-1e5a-44c0-be92-12b4c31a7aca.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3a8975ab84eeae083ce63830f85105fe4300fe4f
--- /dev/null
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@@ -0,0 +1,9 @@
+
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+UUID:E8601979-AE05-4E4D-BB39-6B9C5E67D050 TCGA-LD-A9QF-01A-PR Redacted Surgical Pathology Report DATE OBTAINED: LOCATION: DATE RECEIVED: SUBMITTING MD: DATE REPORTED: CC: DIAGNOSIS 1. LEFt AXILLARy "SENTInEL" LYmPH NODES: NEGATIVE (0/3); NEGATIVE CUTDOWNS SECTIONS. 2. Left AXILLARy "pALpAble" Lymph nODeS: NEgAtive (0/4); NEgAtive CutDOWns SEctiONS. 3. LEFt AXIlLARy "SENTINeL" Lymph nODe: NEGaTIVe (0/1); nEGaTIVE CuTDOWNS SECTIOnS. 4. LEFT AXILLARy "SENTINEL" LYMPH NODES #3: NEGATIVE (0/6); NEGATIVE CUTDOWNS SECTIONS. 5. LEFT TOTAL MASTECTOMy: INVASIVE AND INTRADUCTAL MAMMARy DUCT CARCINOMA. SIZE (INVASIVE): 1.6 cm (additional incidental < 1mm microinvasion) SIZE (DCIS COMPONENT): ~11 cm scattered foci (subareolar region to 11 cm from nlpple @ 12-1 o'clock). LATERALITY: Left TUMOR FOCALITY: Unifocal gross reference mass; incidental microinvasive lesion LESIONAL SITE: Subareolar (both reference mass and incidental microinvasion) HIstologic Type: Invasive ductal carcinoma, apocrine type NUCLEAR GRADE: III of III HISTOLOGIC GRADE:(EEmSBR) III of III (Tubules score 3 + NG score 3 + mitoses score 3) IN-SITU COMPONENT: DCIS (variable histology) comedo NG3 subareolar cribriform non-apocrine with comedonecrosis NG2-3 UOQ cribriform apocrine without comedonecrosis NG2 UOQ LymPH NODE SAMPLING: Negative (0/14); see specimen #1 - #4 AJCC CATEGORIES: Stage ! (assuming "cM0" status). pTNM: pT1c pN0 cTNM: cT1 cNO cMO INTEGRITY/ORIENTATION: Intact specimen with designated margins. MARGINS (invasive and DCIS):  Negative; 3 cm to nearest margins (anterior & posterlor locations) LYMPHOVASCULAR INVASION: Focal MICROCALCIFICATIONS: Present (assoclated with comedo-DCIS) NIPPLE/SKIN: (if applicable)) Negative nipple; numerous pigmented seborrheic keratoses & simple lentigines. SKELETAL MUSCLE Not present OTHER: Two core biopsy sites (1 o'clock subareolar; 12-1 o'ciock u0Q); focal microcysts,.  mammary duct stasis/ectasia and focal usual duct hyperplasia ICD e - 3 (osrimirivsiltrsting duet 85cc13 ***Electronically Signed Out*** C 50.9 c y 1/27|14 COMMENT 1-88329,88307 2-88333,88307 3-88333,88307 4-88307 5-88309 Page 1 of 3
+
+--- Page 2 ---
+Surgical Pathology Report Clinical Diagnosis and History:. ear old female with left invasive CA/DCIS ? extensive DCIS 12-1:00 cT1,cNo,cMo clinical stage I Tissue(s) Submitted: 1: LEFT AXILLARY SENTINEL LYMPH NODES #1 2: LEFT AXILLARY PALPABLE LYMPH NODES 3: LEFT AXILLARY SENTINEL LYMPH NODE #2 4: LEFT AXILLARY SENTINEL LYMPH NODE #3 5: LEFT TOTAL MASTECTOMY SUTURE IN AXILLARY TAIL Gross Description: Specimen #1 is received fresh for intraoperative consultation labeled left axillary sentinel lymph nodes, and consists of three lymph. nodes with attached fat, ranging from 0.2 cm to 2.4 cm in greatest dimension. The lymph nodes are submitted in their entirety for permanent microscopy as follows:. 1A: two lymph nodes 1B:  one lymph node serially sectioned. Specimen #2 is received fresh for intraoperative consultation labeled left axillary palpable lymph nodes, and consists of four lymph nodes, ranging from 0.8 cm to 1.5 cm in greatest dimension. The lymph nodes are serially sectioned to reveal predominantly pink. tan cut surfaces, one of which displays a white focus. A smear preparation from the lymph node with the white focus is performed. The lymph nodes are submitted in their entirety for permanent microscopy as follows: 2A-D:  one lymph node per cassette. Specimen#3 is received fresh for intraoperative consultation labeled left axillary lymph node, sentinel #2, and consists of one, 0.9 cm lymph node, which is serially sectioned and submitted in its entirety labeled 3A. Specimen #4 is received in formalin labeled left axillary sentinel lymph node #3, and consists of six lymph nodes ranging from 0.2 cm to 0.7 cm in greatest dimension. The largest lymph node is bisected and the lymph nodes are submitted in their entirety as follows: 4A: five lymph nodes 4B: one lymph node, bisected. Specimen #5 is received fresh labeled left total mastectomy, suture in axillary tail, and consists of an 858 gm, 25 x 23 x 5 cm left total mastectomy specimen, with a suture marking the axillary tail. There is a 24 x 17 cm, ovoid to elliptical portion of brown skin on the anterior aspect, displaying a 2 x 2 x 1 cm everted nipple. The skin displays multiple brown-black, flat to raised,. predominantly keratotic skin lesions, ranging from 0.1 cm to 1.0 cm and 0.6 to 0.2 cm. The largest lesion is located at 12 o'clock,. 1.7 cm from the nearest 12 o'clock margins. One of the smaller lesions appears to be transected at the 5 o'clock margin. The specimen is inked as follows: superoanterior -- blue, inferoanterior -- green, posterior -- black. The posterior margin is intact. The specimen is serially sectioned to reveal a 1.6 x 1.2 x 1.2 cm tan-white, ovoid, lobulated, indurated mass located retroareolar, 6 cm from the deep margin and 3 cm from the overlying skin. Sectioning of the mass reveals a clip. Anterior to the mass is some dense. fibrosis, displaying possible comedonecrosis. Sectioning of the remaining tibrous tissue reveals a 1.2 x 1.0 x 0.6 cm rubbery, but stellate area of fibrosis at 1-2 o'clock, 11 cm trom the nipple. Sectioning of this area reveals a clip. The clip is located 3 cm from the deep margin, and 6.5 cm from the overlying skin. No definitive gross tumor is associated with this clip. The remaining breast. parenchyma consists of approximately 90% yellow, lobulated adipose tissue, and 10% scattered white, rubbery fibrous tissue. A small portion of tumor and normal are submitted for TCGA studies. Representative sections are submitted as follows: 5A: nipple 5B-5D: mass with clip, no margin. 5E-5G:  representative tibrous tissue anterior to mass, no margin 5H: representative deep margin to mass 5I-5K: stellate area of fibrosis with clip 5L: posterior margin and anterior skin to stellate area of fibrosis with clip 5M-5O: representative fibrous tissue at 12-1 o'clock 5P: representative upper inner quadrant 5Q: representative lower inner quadrant 5R: representative lower outer quadrant 5S: representative upper outer quadrant 5T: representative margin in second largest skin lesion 5U: representative medium five skin lesions 5V: representative smaller skin lesions Time in formalin: 1 p.m, submitted same day Page 2 of 3
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+--- Page 3 ---
+Surgical Pathology Report Intraoperative Consult Diagnosis 1A THREE NEGATIVE LYMPH NODES (BY GROSS). 2A FOUR LYMPH NODES IDENTIFIED; THREE NEGATIVE (BY GROSS); ONE NEGATIVE (BY GROSS AND SMEAR) 3A ONE NEGATIVE LYMPH NODE (BY GROSS AND SMEAR). W 13/2013 END OF REPORT
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diff --git a/output/text/8cd8ccf3-4355-403c-8f23-41a5a3fae6e9.txt b/output/text/8cd8ccf3-4355-403c-8f23-41a5a3fae6e9.txt
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index 0000000000000000000000000000000000000000..a7ebddc8e59e406d08752acb56572a139c882741
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+
+--- Page 1 ---
+SURGICAL PATHOLOGY Case Number : M Diagnosis: A: Liver, capsule at lesser curve of stomach, excision - Dense fibrous tissue with chronic inflammation and necrotic debris with numerous hemosiderin laden macrophages - Negative for malignancy. B: Liver, segments 2 and 3, left hepatic resection Histologic tumor type/subtype: hepatocellular carcinoma (see comment) Histologic grade: grade 3 of 4 (Edmondson and Steiner classification) /cs-0 -3 Tumor location: segments 2 and 3. Carcinomg, hepstrullulw,Nos 811ij 3 Site: lin'csx.o. Tumor size: 10 cm. 13/9/ Focality/extent: unifocal Tumor necrosis/treatment effect: present; tumor appears. approximately 75% viable UUID:AFBED89A-FA3F-45E9-9824-AEE5F891C5B2 TCGA-BC-A3KF-01A-PR Vascular invasion: present. Redactedd Perineural invasion: not identified Capsular invasion: not identified Margins: negative for malignancy; tumor is 4 mm from the cranial. hepatic margin and 4 mm from the caudal hepatic margin Background liver: mild macrovesicular steatosis involving. approximately 20% of hepatic parenchyma. AJCC PATHOLOGIC TNM STAGE: pT2 pNx NoTE: This pathologic stage assessment is based on information. available at the time of this report, and is subject to change pending clinical. review and
+
+--- Page 2 ---
+additional information.. Comment: Immunohistochemical stains are performed and demonstrate the tumor is diffusely positive for HepPar-1 while being negative for Ck7 and ck20.. Vimentin and CD31 outline blood vessels. Overall the immunohistologic and immunohistochemical features are consistent with hepatocellular carcinoma. Intraoperative Consult Diagnosis: from A frozen section was requested by Dr. on. at FsAl: Liver, capsule at lesser curve of stomach, biopsy - Chronic inflammation and fibrosis Drs. at am on Frozen Section Pathologist:, MD Clinical History: The patient is a -year-old female with a clinical diagnosis of. hepatocellular carcinoma. Operation being performed is "left hepatic resection". As per Web. Cis, the patient has a 9.2 x 8.9 mass involving segments 2 and 3 in the left. lobe of the liver. Gross Description: Received are two appropriately labeled containers.. Container A is additionally labeled "liver capsule at lesser curve of stomach" and holds one tan cassette and bits of soft tissue. The cassette is additionally labeled "msll- FsAl". At frozen section specimen A is described as weighing 1.7 grams and measuring 3.4 x 1.7 x 0.5 cm and appears as a red/tan soft tissue fragment that was serially sectioned. A representative
+
+--- Page 3 ---
+section was submitted into block FsAl. On gross examination the. remaining strips of soft tissue are submitted into blocks Al and A2 with no tissue remaining. Container B is additionally labeled "hepatocellular carcinoma, segments 2 and 3 of liver, long stitch = cranial hepatic margin at Ivc, short stitch = caudal hepatic margin". Specimen Type: Left hepatic resection, segments 2 and 3 Specimen Weight: 480 grams Measurement: 12.4 x 10.7 x 8.7 cm Orientation: The margin of resection has been previously inked. as follows: long stitch half/black (cranial), short stitch half/blue (caudal). Mass: The cut section of the liver parenchyma shows a 10 x 7.9 x. 7.5 cm yellow/tan mass; focal areas of hemorrhage and necrosis are evidence, with an estimate percent necrosis at 30% Adjacent liver tissue: Tan with no other masses or lesions identified. Capsule: Shows focal fibrofatty adhesions with an area of the liver mass. The remaining portion of the capsule is smooth. Major portal vein/ hepatic vein: N/A Margins: At closest approach, the liver mass is 0.3 cm away from. the margin of resection. Gallbladder: Not present Block Summary: Inking: Cranial margin/black, caudal margin/blue B1-B2 - Tumor and margin of resection B3 - B4-B9 - Tumor, representative sections B10 - Liver and normal liver, transition B11 - Normal liver
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diff --git a/output/text/8d1f1665-86bb-405b-bbdc-ddc2af77780f.txt b/output/text/8d1f1665-86bb-405b-bbdc-ddc2af77780f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ff027d2d0b30e9e3e865f9f5f9f6ff62c44f736b
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+
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+Page 1 of 3 UUID:52507510-2117-4005-8BB4-234DDFC071ED CGA-SX-A7SP-01A-PR Redacted Result Type:  Surgical Pathology Report Performed By: Encounter info: ID 0 3 Surgical Pathology Report 8qt8/3 *Final* C 64.9 Surgical Pathology Report VtJ 10/413 REVISED REPORT Clinic Number: Name: Requested By: DIAGNOSIS: AMENDMENT REPORT . This amendment is being performed to correct the AJcc pathologic stage grouping. The stage grouping will. be changed to pTlb,NO . Procedure/laterality: Kidney, left, partial nephrectomy. Histologic type: Papillary renal cell carcinoma, type 1.. Nuclear grade (Fuhrman, 1-4): 2 of 4. Tumor size: 5.5 cm in greatest dimension. Tumor site: Midportion left kidney. Tumor focality: Unifocal. Sarcomatoid features: Absent. Tumor necrosis: Absent. Microscopic tumor extension: Extension into perinephric tissue: Not applicable. Extension beyond Gerota's fascia: Not applicable. Extension into renal sinus: Not applicable. Extension into renal vein: Not applicable. Extension into collecting system: Not applicable. Extension into adrenal gland (if applicable): Not applicable. Surgical margins: Negative. Lymph-vascular invasion: Absent. Lymph nodes: Not applicable. Pathologic findings in nonneoplastic kidney: There is insufficient non-neoplastic kidney available for evaluation. Pathologic staging: pTib, NO. Biorepository sample (if applicable): Positive for malignancy. Block(s) containing malignancy suitable for additional testing: A1-A6. DIAGNOSIS COMMENT: Frozen section diagnosis confirmed on permanent sections. Representative sections shared with who concurs.
+
+--- Page 2 ---
+Page 2 of 3 AMENDMENTs: (Previous Signout Date: Revision Description: See final report for amendment reason ...Original Diagnosis.... Procedure/laterality: Kidney, left, partial nephrectomy. Histologic type: Papillary renal celi carcinoma, type 1. Nuclear grade (Fuhrman, 1-4): 2 of 4. Tumor size: 5.5 cm in greatest dimension.. Tumor site: Midportion left kidney. Tumor focality: Unifocal.. Sarcomatoid features: Absent. Tumor necrosis: Absent. Microscopic tumor extension: Extension into perinephric tissue: Not applicable. Extension beyond Gerota's fascia: Not applicable. Extension into renal sinus: Not applicable.. Extension into renal vein: Not applicable.. Extension into collecting system: Not applicable. Extension into adrenal gland (if applicable): Not applicable. Surgical margins: Negative. Lymph-vascular invasion: Absent. Lymph nodes: Not applicable. Pathologic findings in nonneoplastic kidney: There is insufficient non-neoplastic kidney available for evaluation. Pathologic staging: pT2, NX. Biorepository sample (if applicable): Positive for malignancy. Block(s) containing malignancy suitable for additional testing: A1-A6. CLINICAL INFORMATION: Left kidney mass. SPECIMEN(S) : A:Left renal mass PRELIMINARY INTRAOPERATIVE DIAGNOSIS: Intraoperative Pathologist(s): A. Left renal mass, frozen section diagnosis:. Al) Papillary renal cell carcinoma. GROSS DESCRIPTION: Performed by. A. Received fresh labeled and "left renal mass". Procedure: Partial nephrectomy. Specimen laterality: Left. Tumor site: Midportion of left kidney, as indicated in the radiologic imaging. Tumor size: 5.5 x 4.5 x 3.5 cm.
+
+--- Page 3 ---
+Page 3 of 3 Tumor focality: Unifocal. Gross extent of tumor: Extension into perinephric tissue: Absent. Extension beyond Gerota's fascia: Absent. Extension into renal sinus: Not grossly apparent. Extension into renal vein: Not grossly apparent. Extension into collecting system: Not grossly apparent.. Adrenal gland: Absent. Gross notes:. Gross tumor characteristics: Tan-yellow, centrally hemorrhagic,. well-demarcated, solid mass with diffusely soft cut surfaces. Kidney weight: 43 g. Kidney dimensions: 5.5 x 4.5 x 3.5 cm. Distance to margin: The tumor grossly appears to abut the inked parenchymal margin. Lymph nodes: Absent. Inking details: The parenchymal resection margin is inked black. and the margin is designated by the surgeon. Biorepository sample submitted: Yes, see block key. Other: Representative sections from the cut surface of the tumor. are submitted for frozen section in one block. Block key for specimen A: A1) Representative sections from cut surface of tumor, submitted for frozen section. A2-A4) Additional sections of tumor in relation to inked parenchymal margin. A5) Mirror image of tissue submitted for IRB study A6) Section of tumor in relation to outermost surface (renal capsule). Support for the diagnosis in this case may have included the use of immunohistochemistry tests that were developed and whose performance characteristics were determined by  They have not been cleared or approved by the U.s. Food and Drug Administration (FdA). The FDA has determined that such clearance or approval is not necessary. These tests should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 ('cLIA') as qualified. to perform high complexity clinical laboratory testing.
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diff --git a/output/text/8d329d39-f442-4324-9151-d36bde636974.txt b/output/text/8d329d39-f442-4324-9151-d36bde636974.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7dd8d34a085594de00612b62c027540fdf54c1eb
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+
+--- Page 1 ---
+RUN DATE: PAGE 1 RUN TIME: *** FINAL REPORT *** Received: Collected: Copies to. UUID: 36B74E59-F872-40B8-A074-65E3657D438D TCGA-IQ-A61E-01A-PR Redacted SPECIMEN ID: A. NEck, NOs - Right neck dissection levels 2A,3,4, B. NEck, NOs - Right level 1B neck dissection, C. NEck, NOs - Right neck level 2B, D. NEck, NOs - Left neck level lA, lB, E. soFT TrssuE - Right tail of carotid, F. NEck, NOs - Left neck levels 2A,3,4, G. NEck, NOs - Left neck level 2B, H. TOOTH - Teeth #29,30,31, TonguE - Right subtotal glossectomy with right marginal mandibulectomy, I. J. mourh - Right retromolar trigone margin - Frozen section, K. MOUTH - Medial retromolar margin - Frozen section,. L. MOUTH Inferior soft palate - Frozen section,. M. MOUTH - Right floor of the mouth margin - Frozen section, N. MOUTH O. MOUTH - Left floor of the mouth margin - Frozen section, P. Mourh - Right lateral pharyngeal wall margin - Frozen section, Q. mouth - Right vallecula mucosa margin - Frozen section, R. Tongue - Left base of tongue - Frozen section,. S. Tongue - Left posterior tongue dorsal margin - Frozen section, T. neck, nos - Suprahyoid muscle margin - Frozen section,. U. rongue - Left base of tongue deep muscle margin - Frozen section, V.  NErve - Proximal right hypoglossal. nerve margin - Frozen section,. W. mouth - Deep left floor of mouth margin - Frozen section, X. Tongue - Left ventral tongue deep margin, clip inferior - Tongue - Left dorsal tongue margin, clip anterior - Frozen section, - Frozen section, Y. Z. Tongue -- Left deep posterior tongue muscle margin -- AA. Mouth - Deep left middle deep muscle margin - Frozen section, - Frozen section, BB. rongue - Left anterior tongue deep muscle margin - Frozen section , cc. NEck, Nos - Right proximal digastric margin - Frozen section. This report is privileged, confidential and exempt from disclosure under applicable law. If you receive this report inadvertently, please call and return the report to us by mail. zeo-o-3 aeroma, oguam> cll peOS 8870/3 St Jngue NsS Coq.9 QsJ s/4[13
+
+--- Page 2 ---
+PAGE 2 (Continued) RIGHT NECK DISSECTION LEVELS 2A,3,4: Fifteen lymph nodes, negative for malignancy (0/15).. B. RIGHT LEVEL 1B NECK DISSECTION: Salivary gland, no specific pathologic change. One lymph node, negative for malignancy (0/l). C. RIGHT NECK LEVEL 2B: Salivary gland, no specific pathologic change. Eight lymph nodes, negative for malignancy (0/8). D. LEFT NECK LEVEL 1A AND 1B: Salivary gland, no specific pathologic change. Five lymph nodes, negative for malignancy (0/5).. E. RIGHT TAIL OF CAROTID: Salivary gland, nerve, and connective tissue, no specific pathologic change. E. LEFT NECK LEVELS 2A,3,4: Ten lymph nodes, negative for malignancy (0/lo).. G. LEFT NECK LEVEL 2B: Five lymph nodes, negative for malignancy (0/5). TEETH #29, 30, 31: H. Teeth, gross only.. I. RIGHT SUBTOTAL GLOSSECTOMY WITH RIGHT MARGINAL MANDIBULECTOMY: 6 cm in INVASIVE, MODERATELY TO POORLY DIFFERENTIATED SQUAMOUS CELL CARCINOMA, law. This report is privileged, confidential and exempt from disclosure under applicable. If you racaive this roport inadvertently, please call. and return the report to us by mail.
+
+--- Page 3 ---
+PAGE 3 (Continued) *** FINAL DIAGNOSIS *** (Continued) greatest dimension. Perineural invasion is present. No lymphovascular invasion seen. Specimen margins are negative for tumor. See Tumor Summary. AJCC: pT3, pNO, pMX J.  RIGHT RETROMOLAR. TRIGONE MARGIN:S Squamous mucosa, negative for malignancy. K.  MEDIAL RETROMOLAR MARGIN: Squamous mucosa, negative for malignancy. L. INFERIOR SOFT PALATE: Squamous mucosa, negative for malignancy. M. RIGHT FLOOR OF MOUTH MARGIN: Squamous mucosa, negative for malignancy.. N. MIDLINE FLOOR OF MOUTH MARGIN: Squamous and respiratory-type mucosa, negative for malignancy.. O. RIGHT VALLECULAR MUCOSA MARGIN: Squamous and respiratory-type mucosa, negative for malignancy.. P. RIGHT LATERAL PHARYNGEAL WALL MARGIN: Squamous mucosa with underlying lymphoid tissue, negative for malignancy. This report is privileged, confidential and exempt from disclosure under applicable law. If you receive this report inadvertently, please call. and return the report to us by mail.
+
+--- Page 4 ---
+PAGE4 (Continued) * FINAL DIAGNOSIS ** * (Continued) Q.  RIGHT VALLECULA MUCOSA MARGIN: Squamous mucosa with underlying lymphoid tissue, negative for malignancy. R. LEFT BASE OF TONGUE: Squamous mucosa. with underlying lymphoid tissue, negative for malignancy.. s. LEET POSTERIOR TONGUE DORSAL MARGIN: Squamous: mucosa with underlying lymphoid tissue, negative for malignancy.. T. SUPRAHYOID MUSCLE MARGIN: Skeletal muscle, negative for malignancy. U. LEFT BASE OF TONGUE DEEP MUSCLE MARGIN: Skeletal. muscle, negative for malignancy.. V. PROXIMAL RIGHT HYPOGLOSSAL NERVE MARGIN:S Peripheral nerve, negative for malignancy. W. DEEP LEFT FLOOR OF MOUTH MARGIN: Skeletal muscle, negative for malignancy. X.  LEFT VENTRAL TONGUE DEEP MARGIN:S Squamous mucosa, negative for malignancy. Y. LEFT DORSAL TONGUE MARGIN:S Squamous mucosa, negative for malignancy. Z.  LEFT DEEP POSTERIOR TONGUE MUSCLE MARGIN: This report is privileged, confidential and exempt from disclosure under applicable law. If you receive this report inadvertently, please call and return the report to us by mail..
+
+--- Page 5 ---
+AGE 5 (Continued) *** FINAL DIAGNOSIS *** (Continued) Skeletal muscle, negative for malignancy. AA. DEEP LEFT MIDDLE DEEP MUSCLE MARGIN:S Skeletal muscle, negative for malignancy. Bb. LEET ANTERIOR TONGUE DEEP MUSCLE MARGIN: Skeletal. muscle, negative for malignancy. CC. RIGHT PROXIMAL DIGASTRIC MARGIN: Dense connective tissue and skeletal muscle, negative. Pathology Cancer Case Summary Specimen: Ventral surface of tongue, not otherwise specified (nos) Mandible Received: In. formalin Procedure: Resection: Glossectomy (subtotal) Mandibulectomy (marginal) Specimen Integrity: Intact Specimen Size: Tongue: 7 x 4.5 x 3 cm Floor of mouth: 7.5 x 6 x 2 cm Mandibular bone: 3 x 1.2 x 1 cm Specimen Laterality: Not specified Tumor Site: Lateral border of tongue Ventral surface of tongue, NOS Dorsal surface of tongue, NOS Anterior two-thirds of tongue, Nos Tumor Focality:  Single focus Tumor Size: Greatest dimension: 6 cm Additional dimensions: 4 x 3 cm If you receive this report inadvertently, please call and return the report to us by mail.
+
+--- Page 6 ---
+PAGE 6 (Continued) FINAL DIaGNOSIS *** ** (Continued) Tumor Description: Endophytic Ulcerated Histologic Type: Squamous cell carcinoma, conventional Histologic Grade: G2 :  Moderately differentiated to poorly differentiated Margins: Margins Uninvolved by invasive carcinoma Distance from. closest margin: 1 mm or 0.1 cm Specify margin: Soft tissue specimen margin Treatment Effect:. Not identified Lymph-Vascular Invasion: Not identified Perineural Invasion: Present Lymph Nodes, Extranodal Extension: Not identified Pathologic Staging (pTNM): Primary Tumor (pT): pT3: Tumor more than 4 cm in greatest dimension Regional Lymph Nodes (pN): pno: No regional lymph node metastasis Number of Lymph Nodes Examined: 4.4 Number of Lymph Nodes Involved: Distant Metastasis (pM): Not applicable AJCC: pT3, pNO, pMx CLINICAL HISTORY- PRE-OP DX:  Not Provided Not provided RELEVANT CLINICAL HX:. History of SCC (R) Tongue GROSS DESCRIPTION: A. Received in formalin and labeled "Right neck dissection levels 2, 3, 4" are two fibroadipose tissue fragments measuring 9.5 x 3.5 x 1.0 and 4.0 x 3.0 x 0.6 cm. and If you receive this report inadvertently, please call return the report to us by mail.
+
+--- Page 7 ---
+PACE 7 (Continued) GROSS DESCRIPTION: (Continued) diameter. Specimen submitted as follows:. Cassettes #1&2: The same lymph node bisected Cassette #3: Two possible lymph nodes in toto. Cassette #4: Three possible lymph nodes in toto Cassette #5: Four possible lymph nodes in toto Cassette #6: One possible lymph node in toto B. Received in formalin and labeled "Right level 1B neck dissection" and is a 4.8 x 3.5 x 2.0 cm, yellow-tan tissue fragment. Specimen is composed of a salivary gland (3.0 x 2.2 x 1.5 cm) and attached fibroadipose tissue. Three possible lymph nodes are identified, ranging from 0.8 to 1.2 cm in largest diameter.  The cut surface of salivary gland is yellow-tan and lobulated. No lesions are grossly present.. Specimen submitted as follows: Cassette #1: Three possible lymph nodes in toto Cassette #2:  Representative section of the salivary gland. Received in formalin and labeled "Right neck level 2b" is a 3.0 x 2.8 x 1.5 cm. C. fibroadipose tissue. The specimen most likely represents a matted lymph node.  The specimen is bisected and submitted in toto in two cassettes. D. Received in formalin and labeled "Left neck levels 1A and 1B" is an 8.0 x 3.0 x 2.5 cm fibroadipose. tissue fragment. Specimen is composed of a salivary gland (4.0 x 2.8 x 1.5 cm) and attached fibroadipose tissue. No masses or lesions are grossly present in the. salivary gland parenchyma.  Five possible lymph nodes are identified, ranging from 0.2 to 1.3 cm. in largest diameter. Specimen submitted as follows:. Cassette #1: Two possible lymph nodes in toto Cassette #2: Three possible lymph nodes in toto Cassette #3: Representative section of the salivary gland E. Received in formalin. and labeled "Right tail of the Carotid" is a 1.2 x 0.8 x 0.4 cm, pale tan tissue fragment. Specimen is bisected and submitted in toto in one cassette. F. Received in formalin and labeled "Left neck.levels 2A,3,4" is a 9.0 x 4.5 x 1.0 cm fibroadipose tissue fragment. Nine possible lymph nodes are identified, ranging from 1.8 to 0.3 cm in largest diameter. Specimen submitted as follows:. Cassette #1: One possible lymph node, bisected Cassette #2: One possible lymph node, bisected This report is privileged, confidential and exempt from disclosure under applicable law. If you receive this report inadvertently, please call and return the report to us by mail..
+
+--- Page 8 ---
+PAGE 8 (Continued) GROSS DESCRIPTION: (Continued) Cassette #3: Three possible lymph nodes in toto Cassette #4: Four possible lymph nodes in toto G. Received in formalin and labeled as "Left neck level 2B" is a 3.8 x 3.0 x 1.0 cm fibroadipose tissue fragment. Five possible lymph nodes are identified, ranging from 0.8 to 0.2 cm in largest diameter. Specimen submitted as follows:. Cassette #l: Five possible lymph nodes in toto H. Received in formalin and labeled "Teeth #'s 29,30,31" are three teeth ranging from 2.0 cm to 1.5 cm in largest diameter. In the same container, there is also a bone or. tooth fragment measuring 0.6 x 0.3 x 0.2 cm. For gross description only. I. Received in formalin labeled "Right subtotal glossectomy with right marginal mandibulectomy" is a composite resection including tongue (7.0 x 4.5 x 3.0 cm), floor The mucosa (medial margin) is inked red, and soft tissue margin is inked black. There is an. ulcerated, ill-defined, white infiltrating lesion, occupying approximately 8os of the specimen and extending grossly to the soft tissue margin, and measuring 6.0 x 4.0 x. 3.0 cm. It does not reach. the mandibular bone grossly. Sections are submitted as follows: Cassette #1: The tumor with relationship to the margins Cassettes #2-6: Composite section of the tumor Cassette #7: Another representative section. of the tumor Cassette. #8: Tumor with relationship to possible lymph node Cassette #9: The bone margin Cassette #10: Representative section. of bone Received fresh labeled "Right retromolar margin" is a 1.2 x 0.5 x 0.2 cm, pale-tan J. tissue fragment. Specimen submitted toto in one cassette for frozen section. K. Received fresh labeled "Medial retromolar margin" is a 0.8 x 0.5 x 0.3 cm yellow-tan. tissue fragment. Specimen submitted in toto in one cassette for frozen section.. Received fresh labeled "Inferior soft palate" is a 0.7 x 0.5 x 0.2 cm, yellow-tan L. fragment. Specimen submitted in toto in one cassette for frozen section. M. Received fresh labeled "Right floor of mouth margin" is a 1.3 x 0.4 x 0.3 cm,. yellow-tan tissue fragment.  Specimen submitted in toto in one cassette for frozen This report is privileged, confidential and exempt from. disclosure under applicable law. If you raceive this report inadvertently, please call and return the report to us by mail.
+
+--- Page 9 ---
+PAGE 9 (Continued) Gross DesCrIptION: (Continued) section. Received fresh labeled "midline. floor of mouth margin" is a 1.4 x 0.4 x 0.3 cm, N. yellow-tan tissue. fragment. Specimen submitted in toto in one cassette. for frozen section. 0. Received fresh labeled "Left floor of mouth margin" is a 1.4 x 0.3 x 0.3 cm, yellow-tan tissue fragment. Specimen submitted toto in one cassette for frozen section. Received fresh labeled "Right lateral pharyngeal wall margin" is a 1.9 x 0.2 x 0.2 cm, P. yellow-tan tissue fragment. Specimen submitted in toto in one cassette for frozen section. Received fresh labeled "Right Vallecula mucosal margin" is a 1.4 x 0.2 x 0.2 cm, Q. yellow-tan tissue fragment. Specimen submitted in toto in one cassette for frozen section. R. Received fresh labeled "Left base of tongue" is a 1.7 x 0.3 x 0.2 cm, yellow-tan tissue fragment. Specimen submitted in toto in one cassette for frozen section. S. Received fresh labeled "Left posterior tongue dorsal margin" is a 1.9 x 0.2 x 0.2 cm, yellow-tan tissue fragment. Specimen submitted in toto in one cassette for frozen section. T. Received fresh labeled "Suprahyoid muscle margin" is a 2.7 x 0.4 x 0.3 cm, brown soft tissue fragment. Specimen submitted in toto in one cassette for frozen section. U. Received fresh labeled "Left Base of tongue deep muscle margin" is a 1.0 x 0.7 x 0.2 cm, yellow-tan tissue fragment. Specimen submitted in toto in one cassette for frozen section, J. Received fresh labeled "Proximal right Hypoglossal nerve margin" is a 0.4 x 0.2 x 0.2 cm, yellow-tan tissue fragment. Specimen submitted in toto in one cassette for frozen section. W. Received fresh labeled "Left deep floor of mouth margin" is a 1.4 x l.1 x 0.3 cm,. yellow-tan tissue fragment. Specimen submitted in toto in one cassette for frozen section. X Received fresh labeled "Left ventral tongue margin" is a 1.0 x 0.6 x 0.2 cm, This report is privileged, confidential and exempt from disclosure under applicable law. and If you receive this report inadvertently, please call return the report to us by mail.
+
+--- Page 10 ---
+PAGE 10 (Continued) GROSS DESCRIPTION: (Continued) yellow-tan tissue fragment. The margin surrounding the. clip is inked black. submitted in toto in one cassette for frozen section.  Specimen Y. Received fresh labeled "Left dorsal tongue margin" is a 4.3 x 0.3 x 0.2 cm, yellow-tan. tissue fragment. The area surrounding the clip is inked black. Specimen submitted in. toto in one cassette for frozen section. z. Received fresh labeled "Left deep posterior tongue muscle" is a 0.5 x 0.4 x 0.3 cm,. yellow-tan tissue fragment. Specimen submitted in toto in one cassette for frozen. section. AA. Received fresh labeled "Left middle deep muscle margin" is a 0.5 x 0.5 x 0.3 cm, yellow-tan tissue fragment. Specimen submitted in toto in one cassette for frozen section. BB. Received fresh labeled "Left anterior tongue deep muscle margin" is a 0.5 x 0.3 x 0.3 cm yellow-tan tissue fragment. Specimen submitted in toto in one cassette for frozen section. cc. Received fresh labeled "Right proximal digastric margin" is a 4.0 x 2.0 x 0.3 cm, yellow-tan tissue fragment. Specimen submitted in toto in one cassette for frozen section. OPERATING ROOM CONSULT(FS-CYT) J Right retromolar trigone margin: Negative for carcinoma. Medial retromolar margin: Negative for carcinoma. + L Inferior soft palate:  Negative for carcinoma. M Right floor of the mouth margin: Negative for carcinoma. N midline floor of the mouth margin: Negative for carcinoma. 0 Left floor of the mouth.margin: Negative for carcinoma. Right lateral pharyngeal wall margin: Negative for carcinoma. Q Right valecula mucosa margin:  Negative for carcinoma. Left base of tongue: Negative for carcinoma. S Left posterior tongue dorsal margin: Negative for carcinoma. T Suprahyoid muscle margin: Negative for carcinoma. U left base of tongue deep muscle margin: Negative for carcinoma. V Proximal right hypoglossal nerve margin: Negative for carcinoma. W Deep left floor of mouth margin: Negative for carcinoma. X Left ventral tongue deep margin, clip inferior: Negative for carcinoma. Left dorsal tongue margin, clip anterior: Negative for carcinoma. This report is privileged, confidential and exempt from disclosure If you receive this report inadvertently, please call  under applicable law. return the report to us by mail. and
+
+--- Page 11 ---
+.PAGE 11 (Continued) OPERATING ROOM CONSULT (FS-CYT) : (Continued) Z Left deep posterior tongue muscle margin: Negative for carcinoma. AA Deep left middle deep muscle margin: 'Negative for carcinoma. BB Left anterior tongue deep muscle margin: Negative for carcinoma. cc Right proximal dygastric margin: Negative for carcinoma. This report is privileged, confidential and exempt from disclosure under applicable law. If you receive this report inadvertently, please call and return the report to us by mail. W 4/9/13 DISQUALFIED
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diff --git a/output/text/8d8c331b-d2b3-48b2-9050-53bac358be56.txt b/output/text/8d8c331b-d2b3-48b2-9050-53bac358be56.txt
new file mode 100644
index 0000000000000000000000000000000000000000..242bba61e5363e24c2b25ce6d322d0c952ec1bed
--- /dev/null
+++ b/output/text/8d8c331b-d2b3-48b2-9050-53bac358be56.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Icd-0- Causiomt,mfi/tns#ug dut,N0s 8500/3 c50.9 Sit. Busot Nos Diagnosis: Moderately differentiated invasive ductal breast carcinoma with a diameter of 2.2 cm extending cranially to within 5 mm of the resection margin at 3 and 12 o'clock. Norma! follow-up resection material and tumor-free sentinel lymph nodes. Tumor classification: M-8500/3, G2, pT2, pN 0 (sn), MX, R0. UUID:1E002C47-CEC6-491C-9E67-B289687D5B66 Redacted
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diff --git a/output/text/8d9c2407-4c2c-4eee-b5e3-0c585cb42ebd.txt b/output/text/8d9c2407-4c2c-4eee-b5e3-0c585cb42ebd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..27ed4a14ed07dffe98a847878340729269a4dc82
--- /dev/null
+++ b/output/text/8d9c2407-4c2c-4eee-b5e3-0c585cb42ebd.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:3F43AE57-0EB8-4F40-980F-6E2C8C2B3A74 TCGA-E9-A54Y-01A-PR Redacted Gross Description: There is a breast with tumor of irregular shape up to 3 cm in its largest dimension. At the distance of 1.5 cm from the 1st tumor node there is the 2nd node up to 1 cm in size. In the axillary fatty tissue there are lymph nodes with lipomatosis (suspicion of metastases).. Microscopic Description: Infiltrating lobular carcinoma of the breast, G-3, with multicentric type of growth. There are single signet-ring cells. Ten examined lymph nodes demonstrated metastases.. IHC-stainings: ER - positive reaction 98% 3+; PR - positive reaction 50% 3+; Her-2/neu - negative reaction 1+; Ki-67 - 6%. Diagnosis Details: Tumor Features: Indeterminate, Tumor Extent: T2 tumor size more than 2cm not more than 5 cm, Venous Invasion: Not specified, Margins: Absent, Treatment Effect:. Comments: Original records read pT1N2M0. But tumor size is up to 3 cm in largest dimension, which corresponds to T2.. Formatted Path Reports: BREAST TISSUE CHECKLIST Specimen type: Radical mastectomy Specimen size: Not specified 1cD-0-3 Tumor site: Breast carcnvma,ifltruHwy 1okuluv,N0S Tumor size: 0 x 0x 3 cm 8520/3 Sit: bust,Nos c5o.9 Grossly evident lesion: Yes. Histologic type: Lobular carcinoma Histologic grade: Poorly differentiated Tumor extent: Not specified. Lymph nodes: 8/10 positive for metastasis (Axillary 8/10). Extracapsular invasion of the lymph nodes: Not specified Margins: Uninvolved. Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified
+
+--- Page 2 ---
+Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Tumor Features: Indeterminate, Tumor Extent: T2 tumor size more than 2cm not more than 5 cm, Venous Invasion: Not specified, Margins: Absent, Treatment Effect: IHC-. stainings: ER - positive reaction 98% 3+; PR - positive reaction 50% 3+; Her-2/neu - negative reaction 1+; Ki-67 - 6%.Original records read pT1N2M0. But tumor size is up to 3 cm in largest dimension, which. corresponds to T2. IHC-stainings: ER - positive reaction 98% 3+; PR - positive reaction 50% 3+; Her-2/neu - negative reaction 1+; Ki-67 - 6%. Comments: Breast-right 1 20[/3
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diff --git a/output/text/8da25b37-4574-4695-a47f-a8c066fdcaa6.txt b/output/text/8da25b37-4574-4695-a47f-a8c066fdcaa6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e3decf53d9ab6910045d583d8bed0983c9367f3b
--- /dev/null
+++ b/output/text/8da25b37-4574-4695-a47f-a8c066fdcaa6.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Page 1 of 3 MRN Gender M Name Date Of Birth Encounter Number COpy OnLy DO NOt fiLE SURGICAL PATHOLOGY Time Collected Time Received Time Reported Order Number Ordering Provider Status Correction to results  Results Correction Source of Specimen. RIGHT RENAL MASS-NFS- z-o-3 FINAL DIAGNOSIS: RIGHT RENAL MASS-NFS- rraI ceQQ 9q6 0/3 RENAL CELL CARCINOMA, LIMITED TO RENAL TISSUE EXAMINED. S.te  Kidny No5 PROPORTION OF SARCOMATOID COMPONENT: O %. C64.9 SPECIMEN|LATERALITY: RIGHT. JtO 7/24/13 TUMOR FOCALITY: FOCAL. TUMOR SIZE (LARGEST TUMOR, IF MULTIPLE) : 3.8 CM. UUID: F492EF1F-F786-4D10-B59E-D8435F7FAAB1 HISTOLOGIC TYPE: PAPILLARY TYPE. TCGA-1Z-A6M9-01A-PR Redacted HISTOLOGIC GRADE (FUHRMAN NUCLEAR GRADE) : 2/4. TNM STAGE: pTla, pNx, pMX. LYMPH NODE(S) INCLUDED IN ALL PARTS: NONE EXAMINED. LYMPHATIC (SMALL VESSEL) INVASION: IS NOT SEEN. SPECIMEN TYPE: RIGHT PARTIAL NEPHRECTOMY. SpECIMEN SizE: 4.0 x 3.8 x 2.8 CM. Prepared fo
+
+--- Page 2 ---
+Page 2 of 3 ADRENAL GLAND: N/A. NO TUMOR SEEN AT RESECTION MARGINS. EVALUATION OF NON-NEOPLASTIC KIDNEY: TO BE REPORTED IN AN ADDENDUM Signature (Case signed Signed others Frozen section. RIGHT RENAL MASS (GROSS EXAM) : 3.8 CM, WELL-DEFINED NODULE LINED WITH A THIN CAPSULE, CONSISTENT WITH RENAL CELL CARCINOMA. MARGINS ARE INKED AND APPEAR UNINVOLVED ON GROSS EXAM. Frozen section performed by (Frozen $ection signed Case Clinical Information RIGHT RENAL MASS Gross De$cription Received in formalin labeled with the patient's name and "right renal mass Nrs" is a previously inked and serially sectioned partial nephrectomy specimen measuring 4 x 3 x 2.8 cm. The parenchymal margin has been inked black and the capsule margin blue. The cut surface is remarkable for a 3.8 cm, well-defined nodule lined by a thin capsule, consistent with renal cell carcinoma.  The margins grossly appear uninvolved. Representative sections demonstrating mass to capsule and parenchyma=A1-A6 Physiciars Signed Supplemental EVALUATIGN OF NON-NEOPLASTIC RENAL PARENCHYMA SHOWS COMPRESSION ATROPHY IN THE IMMEDIATE VICINITY OF THE TUMOR; THE PARENCHYMA AT THE SURGICAL RESECTION MARGIN SHOWS MILD CHRONIC CHANGES AND MILD VASCULAR SCLEROSIS. Prepared for
+
+--- Page 3 ---
+Page 3 of 3 JONES, PAS AND TRICHROME EXAMINED. (Supplemental Report Signed Procedure A. AA RO$TINE H&E X1 BLOCK.1 H&E X1 A. AA ROUTINE H&E X1 BLOCK.2 H&E X1 A. AA ROUTINE H&E X1 BLOCK.3 H&E X1 A. AA ROUTINE H&E X1 BLOCK.4 H&E X1 A. AA ROUTINE H&E X1 BLOCK.5 H&E X1 JONES PAS TRICHROME A. AA ROUTINE H&E X1 BLOCK.6 H&E X1 Prepared fc
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diff --git a/output/text/8dd481c3-6570-49b6-aa3c-861d6d8c6503.txt b/output/text/8dd481c3-6570-49b6-aa3c-861d6d8c6503.txt
new file mode 100644
index 0000000000000000000000000000000000000000..01f8a869d07384f6192dd7d73c6a3a4fd12d9931
--- /dev/null
+++ b/output/text/8dd481c3-6570-49b6-aa3c-861d6d8c6503.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Case ID Excision date
+
+--- Page 2 ---
+Gross Microscopic Description Diagnosis Details Description Part of the stomach The 1st conclusion: in the gastric Tumor Features: Unknown, with saucer-like wall there is a tumor with diffuse Tumor Extent: 0, Venous tumor up to 5.5 cm type of growth, which is consised Invasion: Absent, Margins: in size, with muscle of small-size cells with Absent, Treatment Effect: Iayer invasion. In. hyperchromatic nuclei. Tumor is the fatty tissue replace gastric mucosa and spread there are soft on the muscle layer. Morphological hyperemic lymph. structure is consistent with non- nodes. Omentum is Hodgkin's lymphoma. IHC-stainings hyperemic. are recomended. Fifteen Iymph nodes demonstrated reactive changes. Omentum demonstrated focal Iymphoid infiltration.. The 2nd conclusion: in the gastric wall there is a tumor, which is consist of middle-sized Iymphoid cells, but there are some regions with large atypical cells with high proliferative activity. IHC stainings: CD20+, CD3-, CD5-, CD10-, CyclinD1-, Ki67 - focaly 60%. Final conclusion: Non-Hodgkin's marginal zone B-cell Iymphoma
+
+--- Page 3 ---
+Comments Formatted Path Report IHC stainings: CD20+, STOMACH TISSUE CHECKLIST CD3-, CD5-, CD10-, CyclinD1-, Ki67 - focaly Specimen type: Subtotal resection of stomach. 60%. Tumor site: Antrum Tumor size: 0 x 0 x 5.5 cm Tumor features: None specified Histologic type: Diffuse large b-cell lymphoma. Histologic grade: Tumor extent: Not specified Lymph nodes: 0/15 positive for metastasis (Greater and lesser curvature. 0/15) Lymphatic invasion: Not specified Venous invasion: Not specified Perineural invasion: Not specified Margins: Not specified. Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified. Comments: None
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diff --git a/output/text/8e26c786-e144-4ce2-9792-fe957cd03aa8.txt b/output/text/8e26c786-e144-4ce2-9792-fe957cd03aa8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ab580cffaff60e90cc11aed526f08b1a1191dc9e
--- /dev/null
+++ b/output/text/8e26c786-e144-4ce2-9792-fe957cd03aa8.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1es-o-3 carcinoma, infilmnuting duct Nsos 850tf3 lw 5/19/H UUID:1281F503-C256-4DFF-A3BD-BD5E51CE4249 TCGA-D8-A27L-01A-PR Redacted page 1 / 1 copy No. 2 Date: Examination: Histopathological examination Internal invoice No. Value of diagnostic procedure Examination No.: Patient: xxx PESEL: XX Age: Gender: F Material: Multiple organ resection - right breast! Unit in charge: Physician in charge: Material collected on: Material received on: Expected time of examination: up to 8 working days Clinical diagnosis: Cancer of the right breast. Examination performed on:. Macroscopic description: Right breast'sized 19.0 x 14.0 x 2.5 cm removed without axillary tissues and with a skin flap of 14 x 8 cm. Tumour sized 1.1 x 0.6  x 1.0 cm found in upper inner quadrant, located 2.5 cm from the lower boundary, 0.5 cm from the base and 1.0 cm from the. skin. Microscopic description: Carcinoma ductale invasivum NHG1 (2 + 2 + 1/5 mitoses/10 HPF - visual area 0.55 mm). Numerous foci of carcinoma ductale in situ (Dcis) found within the tumour (cribrate type with medium nuclear atypia and point. necrosis, 30% of the tumour). Mamilla sine laesionibus.. Glandular texture showing lesions of the type mastopathia fibrosa et cystica.  Invasive lesions are situated 5 cm from the base. Histopathological diagnosis: Carcinoma ductale invasivum et in situ mammae dextrae. Invasive and in situ ductal carcinoma of the right breast. j ( NHG1, pT1c, pNx). Compliance validated by: dr Examination performed on:  Results of immunohistochemical examination: Estrogen receptors found in over 75% of neoplastic cell nuclei. Progesterone receptors found in over 75% of neoplastic cell. nuclei. HER2 protein stained with Ventana's Pathway HER-2/neu (4B5) Rabbit Monoclonal Antibody. Negative reaction in. invasive cancerous cells (Score=1+). dr dr
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diff --git a/output/text/8e33f6a5-dbe4-4c1d-9a48-06fe6ac1f9fe.txt b/output/text/8e33f6a5-dbe4-4c1d-9a48-06fe6ac1f9fe.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d7d366203b7ca029b976cbb222c3b8d4e70676fb
--- /dev/null
+++ b/output/text/8e33f6a5-dbe4-4c1d-9a48-06fe6ac1f9fe.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:0250A7AA-A53D-4DCB-BF74-04FABD979B25 CGA-RQ-A6B-01A-PR Redacted zCD o-3 Eyuse Lorge Beee Diagnosis: anol asdociatil Subgaleal Mass 0 C4i.D -Large Cell Lymphoma, B-Cell Type of probable follicular center cell origin. 4s 4lQ8f1 3 Discussion: The neoplastic cells are immunoreactive for CD45 and CD20. Scattered CD3 positive T- cells are present as well as scattered CD68 positive monocytes/macrophage lineage cells. The tumor cells are diffusely immunoreactive for vimentin. They are negative for cytokeratin, CD 99, desmin, synaptophysin, S-100 and CD34. Overall, the findings confirm a diagnosis of a B-cell lymphoma. Microscopic Description:. Sections demonstrate sheets of large, non-cohesive cells. Whereas the nuclei are enlarged, there is only modest cytoplasm. The nuclei range from open to hyperchromatic and rounded to angulated to cleaved and lobulated. Scattered mitotic figures are seen. There are no specifics differentiating features.
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diff --git a/output/text/8e57c7c9-ba64-4508-bb4f-201fcb5ed6dd.txt b/output/text/8e57c7c9-ba64-4508-bb4f-201fcb5ed6dd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a97ab9e62cdd91780a4be5d057f68acb84ea96cf
--- /dev/null
+++ b/output/text/8e57c7c9-ba64-4508-bb4f-201fcb5ed6dd.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:338D5387-0CFB-4D91-944F-1F054C21C769 TCGA-AN-A0FT-01A-PR Redacted TSS Patient ID: Case #: DOB: Sex: Female Ethnicity (Race): Cancer Sample Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma. Date of Procurement: Anatomic Site: Right breast Tumor location: Primary Tissue Specification: Tumor Specimen Matrix: Tissue Specimen Format: OCT Container: block Type of Procurement: surgery Grade: 2. T Stage: 2 N Stage: 1 M Stage: 0 Treatment: none Treatment Details: n/a  Normal Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw. Matrix: Blood Specimen Format: frozen Container: tubee Date of Procurement: Ics-0-3 carcnome, lnfiltrxHnj cluct; N0j 85oc/3 Sih: brust, Nos C.50.9 tofarfr!
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diff --git a/output/text/8e7df866-6e77-47b5-b82b-afec67d11b75.txt b/output/text/8e7df866-6e77-47b5-b82b-afec67d11b75.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fb2974a42426c8a47ed4c1ef61cf625aa1bed0bd
--- /dev/null
+++ b/output/text/8e7df866-6e77-47b5-b82b-afec67d11b75.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+Clinical Diagnosis & History: IDC.on core biopsy of left breast. Specimens Submitted: 1: sP: Sentinel node #1 level 1 left axilla (fs). 2: SP: Sentinel node #2 level 1 left axilla (fs) 3: SP: Sentinel node #3 level 1 left axilla (fs). 4:SP: I Left breast mass UUID:D9432167-0F2E-4377-9DB4-EA4E59A6C9B9 5: sp: Superior margin left breast TCGA-AO-A1KT-01A-PR Redacted 6:SP: Medial margin left breast 7: SP: Inferior margin left breast 8: SP: Lateral margin left breast 9: Sp: Deep margin left breast 10: sp: Additional suspicious lymph node left axilla DIAGNOSIS: 1) SENTINEL LYMPH NODE #1, LEVEL I, LAFT AXILLA; EXCISION: - ONE LYMPH NODE SHOWING MICROSCOPIC CLUSTER OF TUMOR CELLS (APPROXIMATELY 8 CELLS; < 0.2 MM) WITHIN CAPSULAR LYMPHATIC VESSEL. -THE TUMOR IS IDENTIFIED ON CYTOKERATIN STAINS AND CORRESPONDING DEEPER Jcs-0-3 LEVEL H&E AND NEGATIVE CONTROL SLIDE. Cannona,iifiltrating ouctel, Nos 2) SENTINEL LYMPH NODE #2. LEVEL I, LEFT AXILLA; EXCISION: 8500|3 -BENIGN LYMPH NODE O/1). - ADDITIONAL HSE-STAINED SECTIONS AND IMMUNOHISTOCHEMICAL STAINS FOR CYTOKERATINS (AE1:AE3) SHON NO EVIDENCE OF METASTATIC TUMOR. St+e: braot, Nos C50.9 Jr 211/11 SENTINEL LYMPH NODE #3. LEVEL I. LEFT AXILLA: EXCISION: -BENIGN LYMPH NODE O/1). ADDITIONAL H&E-STAINED SECTIONS AND IMMUNOHISTOCHRMICAL STAINS FOR CYTOKERATINS (AEI:AE3) SHOW NO EVIDENCE OF METASTATIC TUMOR. 4) BREAST,LEFT) MASS: ECISION: INVASIVE DUCTAL CARCINOMA, POORLY DIFPERENTIATED. HISTOLOGIC GRADE HII/III, NUCLEAR GRADE III/III, MEASURING 1.9 CM MICROSCOPICALLY. - FOCAL DUCTAL CARCINOMA IN SITO (DCIS). SOLID AND CRIBRIFORM TYPE WITH INTERMEDIATE TO HIGH NUCLEAR GRADE AND NECROSIS. THE DCIS CONSTITUTES < 25% OF THE TOTAL TUNOR MASS, AND IS PRESENT ADMIXED WITH AND ADJACENT TO THE INVASIVE inued on next page
+
+--- Page 2 ---
+-- Page 3 of 6 I ATTEST THAT THE ABOVE DIAGNOSIS IS BASKD UPON MY PERSONAL EXANINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. **. Report Electronically Signed Out *** Special Studies: Result Special stain RECUT Gross Description: The specimen is received fresh for trozen section consultation, labeled.. "Sentinel node #l, level 1. left axilla", and consists of one lymph node measuring 1.0 x 2.6 x 0.5 Cm, which is bisected and antirely submitted. Summnary of sections: frozen section control (one node). The specimen is received fresh for frozen section consultation, labeled,. 2. "Sentinel node #2, level 1, left axilla",. and consiats of One ly-ph nod. measuring 1.lx 0.4 x 0.3 Cm, which is entirely submitted. Summary of sections: FSC -- frosen section control (one node) The spaciman is received fresh for frozen aoction consultation, labeled, . "Sentinel node #3, level 1, left axilla*, and consists of. two possible lymph nodes measuring 0.3 x 0.3 x 0.2 cn in aggregate. Entirely submitted. Summary of sections: Fsc --* frozen section control (two possible nodes) The specimen in received unoriented, labeled "Left breast mass " and 4). consists of a piece of fibrofatty tissue measuring 6 x 3.8 x 2.5 cm.. The specimen is entirely inked black.  Serial sectioning reveals a 1.5 x I x 1 cm tan-white firm mass with central hemorrhage. Sectioning through the Xemaining tissue roveals fatty breast parenchyma. The tumor is antirely submitted and the remaining tissue is representatively submitted. Sumnary of sections: NT  - tumor and closest tisaue edge. SS - serial sections of remaining tissue *+ Continued on next page
+
+--- Page 3 ---
+Page s of 6 dir sion. All idantified lymph nodes are submitted. Sumary of sections:. BLN - bisacted lynph nodes ary of Sections:. Part i: SP: Sentinel node #1 level 1 left axilla (fs) Block Sect. Site PCs 1 rsc 1 Part 2: SP: Sentinel node #2 level 1 left axilla (fs) Block Sect. Site PCs 1 rsc 1 Part 3: SP Sentinel node #3 level 1 left axilla (fs) Block Sect. Site PCs 1 FSC : Part 4: SP: Loft breast. Block Sect. site PCs 3 Part5 SP: Superior margin left breast. Block Sect. Sita PCs s8 Part6 SP: Medial margin left breast. Block Sect. Site PC Part 7: t breast Block Sect. Site PCs 2 $s Part Block Sect. Site PCs 2 ss Part 9: SPDeep zgin left Block Sect. Site PCs
+
+--- Page 4 ---
+.-- xeport Electronicatly s+yue. --c *** (1) :118-145). LAB NOTES HER2/ CEP DIAGNOSTIC INTERPRETATION: verage ... 17 of ERABOVE ** Continued on next page **. HER2 tum Formalin S).S MASmA! nucleus: FDA-approved Yes The HER2
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index 0000000000000000000000000000000000000000..fb7b053f532045176895d5a92b91f8db49f4e48e
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+Sample Number Sample Type  TUMOUR  Diagnosis Adenocarcinoma  Year of Sample Collection. Age at Sample Collection (yrs) Days to Procedure Date  Days to Diagnosis Type of Procedure RESECT Site of Tissue/Primary (Histology) Esophagus (involves GEJ)* Tumour Size (cm) 5.5  Histology Adenocarcinoma  Grade/Differentiation 11  Pathological T T3 Pathological N  NO Clinical M MO Histology Commentse *Tumour midpoint is in distal esophagus Sample Number Sample Type BUFFY  Year of Sample Collection Age at Sample Collection (yrs) Days to Procedure Date  Days to Diagnosis UUID:F166E07E-53FF-464E-A107-315F64F5FF7C TCGA-M9-A5M8-01A-PR Redacted D-s-3 Adeuocar<inomc N0S 8146/3 Path. S;+e EsphagusN6S C15.9 Esophaqus;distaJthird C15.5 KCF Q Q//13 lw s{|3 riteria
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diff --git a/output/text/8ea2a2e3-c3b4-43b2-bebb-fad64d496d98.txt b/output/text/8ea2a2e3-c3b4-43b2-bebb-fad64d496d98.txt
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index 0000000000000000000000000000000000000000..bba884d45f5aae064f7ba9d236bdaa6135a7b7ef
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+Carnoma, mf tro$nq duct,N0S 3tripu nrgatie 8500|3 12/8/10 lw Pasth Sit: brsst, Nos cQcF c 50.9 TSS: . UUID:734305A3-5EC4-4DE4-B263-91A49082F146 TCGA-E2-A14X-01A-PR Redacted SPECIMENS: A. RIGHT BREAST WLE NEEDLE LOCALIZATION B. ADDITIONAL ANTERIOR INFERIOR MARGIN C. ADDITIONAL SUPERIOR MARGIN D. SENTINEL LYMPH NODE #1 E. SENTINEL LYMPH NODE #2 F. RIGHT AXILLARY CONTENTS LEVELS 1 & 2 SPECIMEN(S): A. RIGHT BREAST WLE NEEDLE LOCALIZATION B. ADDITIONAL ANTERIOR INFERIOR MARGIN C. ADDITIONAL SUPERIOR MARGIN D. SENTINEL LYMPH NODE #1 E. SENTINEL LYMPH NODE #2 F. RIGHT AXILLARY CONTENTS LEVELS 1 & 2 GROSS DESCRIPTION: A. RIGHT BREAST WLE NEEDLE LOCALIZATION Received fresh labeled with the patients identification and "Right Breast WLE needle localization" is an oriented (Single-Anterior, Double-Lateral, Triple-Superior and Quadruple-Inferior) 59g, 8.5 x 8.5 x 2.5cm needle localized Iumpectomy with 2 radiographs. Ink code: Anterior-Yellow, Posterior-Black, Superior-Blue, Inferior-Orange, Medial- Green, Lateral-Yellow. Specimen serially sectioned from medial to lateral into 7 slices revealing a 2.5 x 1.5 x 1.5cm. tan white firm well circumscribed mass abutting the anterior and posterior margins in slices 3-5. A portion of the specimen is submitted for tissue procurement. Representative sections are submitted. A1-A3: medial margin slice 1 A4: superior margin slice 2. A5-A6: anterior margin slice 3 A7-A8: deep margin slice 3 A9-A11: anterior margin slice 3 A12-A14: deep margin with mass in A13 slice 3 A15: superior margin slice 4. A16: mass with anterior/deep margin slice 4. A17-A18: mass with anterior margin slice 4. A19-A20: mass with deep margin slice 4 A21: superior margin slice 5 A22-A23: mass with anterior/deep margin slice 5 A24: inferior margin slice 5 A25: area next to mass with anterior/deep margin slice 6 A26: lateral margin slice 7 B. ADDITIONAL ANTERIOR INFERIOR MARGIN Received fresh labeled with the patient's identification and "Additional Anterior/lnferior margin" is an oriented (Single Anterior, Double-Inferior) 19g, 5 x 5 x 2.5cm fragment of fibrofatty tissue. Final Anterior margin is inked Yellow and  the final Inferior margin is inked Orange. Serial sectioning reveals no discrete lesions. Toto B1-B14.. C. ADDITIONAL SUPERIOR MARGIN Received fresh labeled with the patient's identification and "Additional Superior margin" is an oriented (Single Anterior, Double-Inferior) 10g, 3 x 3 x 2cm fragment of fibrofatty tissue. Final margin is inked Black. Serial sectioning reveals no discrete lesions. Toto C1-C7. D. SENTINEL LYMPH NODE #1 Received fresh labeled with the patient's identification and "SLN #1" are two possible lymph nodes 0.8 x 0.8 x 0.5cm and 0.5 x 0.3 x 0.2cm. A touch prep is taken and the larger lymph node is submitted in FSD. The smaller possible iymph node is submitted in D2. E. SENTINEL LYMPH NODE #2 (CLUMP OF FREE NODES) Received fresh labeled with the patient's identification and "SLN #2" are 3 tan pink lymph nodes ranging from 1.4 x 0.9 x 0.8cm to 1.4 x 0.8 x 0.6cm. Toto FSE1, FSE2 and FSE3. F. RIGHT AXILLARY CONTENTS LEVELS 1 & 2 Received in formalin are multiple tan pink soft tissue fragments aggregating to 10 x 10 x 4cm. Dissection reveals multiple lymph nodes. Entirely submitted: F1: 5 lymph nodes F2: 5 lymph nodes F3: 1 lymph node F4: 1 lymph node F5: 1 lymph node F6: 1 lymph node
+
+--- Page 2 ---
+F7-F8: 1 lymph node F9-F10: 1 lymph node F11-F12: 1 lymph node F13-F20: axillary tissue RESULTS: SUMMARY OF IMMUNOHISTOCHEMISTRY/SPECIAL STAINS Material: Block A1 Population: Tissue Stain/Marker: Result: Comment: CALP Positive In DCIS Material: Block A12 Population: Tissue Stain/Marker: Result: Comment: CD31 Positive Material: Block A24 Population: Tissue Stain/Marker: Result: Comment: CD31  Positive Material: Block B7 Population: Tissue Stain/Marker: Result: Comment: ESTROGEN RECEPTOR Positive Heterogeneous staining consistent with UDH The interpretation of the above immunohistochemistry stain or stains is guided by published results in the medical literature, provided package information from the manufacturer and by internal review of staining performance and assay validation within the Immunohistochemistry Laboratory. The use of one or more reagents in the above tests is regulated as an analyte specific reagent (ASR). These tests were developed and their performance characteristic determined by the Department of Pathology Laboratory. They have not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. Special stains and/or immunohistochemical stains were performed with appropriately stained positive and negative controls. DIAGNOSIS: A. BREAST, RIGHT, NEEDLE LOCALIZATION WIDE LOCAL EXCISION - INVASIVE DUCTAL CARCINOMA, SBR GRADE 3, WITH MICROPAPILLARY FEATURES(SEE NOTE) - INVASIVE CARCINOMA MEASURES 2.5 CM. - INVASIVE CARCINOMA IS PRESENT AT THE ANTERIOR MARGIN AND IS 0.3 CM FROM THE POSTERIOR MARGIN.  EXTENSIVE LYMPHVASCULAR INVASION IS PRESENT. - DUCTAL CARCINOMA IN SITU (DCIS), SOLID TYPE, NUCLEAR GRADE 3, WITH NECROSIS, MINOR COMPONENT. - DCIS IS FOCALLY WITHIN O.4 CM OF THE MEDIAL MARGIN. - PREVIOUS BIOPSY SITE CHANGES PRESENT. NOTE: The additional anterior inferior margin (specimen B) is free of invasive carcinoma. Surgical correlation is recommended. CD31 stains show positive staining around tumor foci near superior and posterior margins consistent with tumor in lymphvascular channels.
+
+--- Page 3 ---
+B. BREAST, RIGHT, ADDITIONAL ANTERIOR INFERIOR MARGIN, EXCISION: - FOCAL ATYPICAL DUCTAL HYPERPLASIA (ADH) AND USUAL DUCTAL HYPERPLASIA (UDH) C. BREAST, RIGHT, ADDITIONAL SUPERIOR MARGIN, EXCISION: - INVASIVE DUCTAL CARCINOMA, SBR GRADE 3.E - TUMOR MEASURES 0.6 CM. - TUMOR IS WITHIN O.2 CM OF THE NEW MARGIN.E - LYMPHVASCULAR INVASION IS PRESENT. - DCIS, SOLID TYPE, NUCLEAR GRADE 3, WITH NECROSIS, MINOR COMPONENT. D. SENTINEL LYMPH NODE #1, RIGHT AXILLA, BIOPSY: - ONE LYMPH NODE, NO TUMOR SEEN (O/1). E. SENTINEL LYMPH NODE #2, RIGHT AXILLA, BIOPSY: - mETASTATIC CARCINOMA TO TWO OF THREE LYMPH NODES, LARGEST METASTASIS IS O.7 CM, WITH NO EXTRANODAL EXTENSION (2/3) F. AXILLARY CONTENTS, RIGHT, LEVELS 1 AND 2, DISSECTION: - METASTATIC CARCINOMA TO 3 OF 17 LYMPH NODES, LARGEST METASTASIS IS 1.5 CM WITH EXTRANODAL EXTENSION (3/17). SYNOPTIC REPORT - BREAST Specimen Type: Excision Needle Localization: Yes - For mass Laterality: Right Invasive Tumor: Present Multifocality: Yes WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Tumor size: 2.5cm Tumor Site: Upper outer quadrant Margins:  Negative Distance from closest margin: Less than 0.2cm superior Tubular Score: 3 Nuclear Grade: 3 Mitotic Score: 3 Modified Scarff Bloom Richardson Grade:. Necrosis: Absent Vascular/Lymphatic Invasion: Present Extent: extensive Lobular neoplasia:  None Lymph nodes: Sentinel lymph node and axillary dissection Lymph node status: Positive 5 / 21 Extranodal extension Non-neoplastic areas: fibroadenoma DCIS present Margins uninvolved by DCIS DCIS Quantity:Estimate 5% DCIS Type: Solid DCIS Location:Associated with invasive tumor Nuclear grade: High Necrosis: Present ER/PR/HER2 Results ER: Negative PR: Negative HER2: Negative by IHC Pathological staging (pTN): pT 2 N 2 SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimen: Surgical Excision Block Number: A22 and F12 (lymph node)
+
+--- Page 4 ---
+ER: Negative Allred Score: 0 = Proportion Score 0 + Intensity Score 0. PR: Negative Allred Score: 0 = Proportion Score 0 + Intensity Score 0. COMMENT: The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring range from 0 to 8. ER/PR positive is defined as an Ailred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2. METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Immunohistochemistrv was nerfnrmed using the mouse anti-human ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) provided by Dako ., following the manufacturer s instructions. This assay was not modified.. Interpretation of the ER/PR immunohistochemical stain is guided by published results in the medical literature.  information provided by the reagent manufacturer and by internal review of staining performance. SYNOPTIC REPORT - BREAST HER-2 RESULTS Specimen: Surgical Excision Block Number: F12 (lymph node) Interpretation: NEGATIVE Intensity: 1+ % Tumor Staining: 5% Fish Ordered: No METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no lonaer than 24 hours. Her2 analysis was performed using the FDA approved Dako HercepTest (TM) test kit using rabbit anti- human HER2. This assay was not modified. External kit-slides providea by the manufacturer (cell lines with high,  low and negative HER2 protein expression) and in-house known HER2 amplified control tissue were evaluated along with the test tissue. Adequate, well preserved, clear-cut invasive carcinoma was identified for HER2 evaluation. Interpretation of the HER2 immunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal review of staining performance. This assay has been validated according to the 2007 joint re. commendations and guidelines from ASCO and CAP  and from the NCCN HER2 testing in Breast Cancer Task Force. The Pathology Department takes full responsibility for this test's performance. CLINICAL HISTORY: year old female with Abnormal MMG- Bx Right Breast at 9-10 o'clock IDC ER-. MRI showed additiona! abnormality 2.6cm posterior to this.. PRE-OPERATIVE DIAGNOSIS: Right Breast Cancer INTRAOPERATIVE CONSULTATION: FSD-TPD: One lymph node negative for tumor. FSE1-FSE2-FSE3: Positive for metastatic Adenocarcinoma. Diagnoses called to Dr. at . (D) and i (E) by Dr. Gross Dictation: Pathologist, Microscopic/Diagnostic Dictation: Pathologist, Final Review: Pathologist, . Final Review: Pathologist, Final: Pathologist,.
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+FINAL DIAGNOSIS Part 1: gallbladder, cholecystectomy- CHrONIC ActIVE ChOLEcysTiTis wIth mARKEd inCrEASe iN EOsINOphILS Part 2: kidney, Left, nephrectomy -. RENAL CeLL CARcINOmA, CONVenTIONAl (CLEAR) CELl tYpE TCGA-B0-4833 A. B. fUhRMAN'S NUCLEAR GRADE JS ii Of iV c. RENAL CELL CARCINOMA GROWS IN ACINAR PATTERN OF GROWTH D. The grEatest diameter of the neoplAsm Is 5 cm.. E. THE NEOPLASM IS CONFINED WITHIN THE RENAL CAPSULE i uO NO INVASION OF THE RENAL VEIN iS IDENTIFIED NO EVIDENCE Of ANGIOLYMPHATIC iNVASIOn iS iDENTIfIeD. H. ALL SURGICAL MARGInS ARE FREE Of THE NEOpLASM I. THE NON-NEOPLASTIC KIDNEY IS UNREMARKABLE THE ADRENAL GLAND IS NOt IDeNTifIeD TNM STAGE: pT1b NX MX, L. TNm histoLOgic grade = G2.
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diff --git a/output/text/8ebfaf92-42b2-4218-b65d-516df75aa601.txt b/output/text/8ebfaf92-42b2-4218-b65d-516df75aa601.txt
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index 0000000000000000000000000000000000000000..9ddb53c807e5224b7b716de50912e619d883b841
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+UUID:0D074A99-0D21-4430-B82F-28E56A0D4242 Redacted IeD-s-3 PATH : Carcinome wj osteoclast liKe Giait Cells 8635f3 Gender: Male PaH Site:Bladder, postriorond larrat lekl Race: White @67.8 CSCF Site:Bladder, pcstwier lib)1 Cb7.4 Pathology Report: Q /2/24 /1 2 Surgical Pathology Report FINAL PATHOLOGIC DIAGNOSIS A. Left pelvic lymph node; lymphadenectomy: - Eight lymph nodes, no tumor (0/8). B. Urinary bladder, prostate, left and right vas deferens; cystoprostatectomy: - Bladder with invasive osteoclast-like giant cells rich poorly differentiated urothelial carcinoma, invading thru the muscularis propria and into the perivesical soft tissue, see pathologic parameters and comment. - Tumor shows multifocal lymphovascular invasion and spread within the bladder wall to perivesical soft tissues. - Posterior bladder and right ureter margins, positive for tumor. - Prostate with incidental prostatic adenocarcinoma, see pathologic parameters. C. Right pelvic lymph nodes; lymphadenectomy: - Soft tissue deposits of metastatic osteoclasts-like giant cell rich urothelial carcinoma, see comment. Urothelial Carcinoma Pathologic Parameters 1. Tumor type: Invasive poorly differentiated osteoclast-like giant cells rich urothelial carcinoma, see comment. 2. Grade of tumor: High grade. 3. Depth of invasion: Extravesicular soft tissue (macroscopic). 4. Tumor distribution: Large mass (4.0 cm) at inferior posterior and right lateral wall, and with multiple small tumor foci in bladder wall at anterior, posterior, right lateral and trigonal walls; additional free-floating/detached tumor fragments that measured 11 cm and 3.2 cm. 5. Ureteral margins: Right ureter, positive for tumor. 6. Distal urethral margin: Negative for tumor. 7. Soft tissue margin or serosa: Positive for tumor (multifocal)
+
+--- Page 2 ---
+8. Lymph nodes: Soft tissue deposits of urothelial carcinoma at right pelvic 1ymph node area. 9. pTNM: pT3b,N1,MX, R1, see comment Effective this Checklist utilizes the 7th edition TNM staging system for Bladder of the American Joint Committee on Cancer (AJCC) and the International Union Against Cancer (UICC). Radical Prostatectomy Pathologic Parameters 1. Gleason Score: 3+3=6. 2. Perineural Invasion: Absent. 3. Tumor Location: Peripheral zone - left (slide B10). 4. Tumor Volume Estimate: 5%. 5. High-grade P.I.N.: Multifocal. 6. Seminal Vesicles: Negative for tumor.. 7. Extraprostatic Extension: Absent.. 8. Peripheral Margin: Negative for tumor. 9. Distal (apical) Margin: Negative for tumor.. 10. Proximal (basilar) Margin: Negative for tumor. 11. Regional Lymph Nodes (right and left): Negative for prostate carcinoma (0/8). 12. pTNM: pT2a,N0,MX. Effective is Checklist utilizes the 7th edition TNM staging system for prostatectomy of the American Joint Committee on Cancer (AJCC) and the International Union Against Cancer (UICC). Comment The bladder tumor has a very unusual morphology in that it shows dense solid growth of predominantly epithelioid cells with focal spindling and few loose myxoid areas. The epithelioid tumor cells are high grade, have modest amphophilic cytoplasm and with brisk mitotic activity. In addition, numerous osteoclast-like giant cells are distributed all throughout the tumor. Foci of tumor necrosis are also present. Immunohistochemical stains performed show that the tumor cells are nuclear positive for GATA3 and with rare nuclear positivity for p63. Keratin Cam5.2, CK7 and CK20 are negative. The positivity for GATA3 and p63 are supportive for urothelial carcinoma. Controls appropriate. Rare occurrence of osteoclast-like giant cells rich carcinoma, similar to the current case, has been reported in the urinary tract. The few cases previously reported showed an aggressive biologic behavior, see reference. On part C, the right lymphadenectomy specimen shows large soft tissue deposits
+
+--- Page 3 ---
+of carcinoma, which may represent overgrowths from a lymph nodal tumor metastasis. No normal lymph node tissue however is identified. Of note, right pelvic lymphadenectomy was performed previously (together with ureterectomy,. which was negative for tumor. Nodal status for the current bladder tumor. is most consistent with N1. Reference: 1. Baydar D, Amin MB, Epstein JI. Osteoclast-rich undifferentiated carcinomas of the urinary tract. Mod Pathol. 2006;19:161-71. xx [] MD Interpretation performed by the Attending Pathologist and reviewed with the. Resident/Fellow, [] MD Electronically Signed Out by [] MD Clinical History: Patient is an  year-old male with high-grade urothelial carcinoma undergoing radical cystectomy, prostatectomy, and lymph node dissection. Specimens Received:. A: Left pelvic lymph node B: Bladder, prostate, left and right vas differens. C: Right pelvic lymph node Gross Description: The specimens are received in three containers each labeled with the patient's name and medical record number. A. The first container is additionally identified as, "Left pelvic lymph node". Received in formalin is an aggregate of yellow-tan, soft, and lobulated tissue fragments ranging in size from 1.1-1.4 cm in greatest dimension. The specimen is. dissected to reveal 10 lymph node candidates ranging in size from 0.3-1.3 cm in greatest dimension. The specimen is submitted as follows:. A1: 3 lymph node candidates A2: 2 lymph node candidates A3: 2 lymph node candidates A4: 2 lymph node candidates A5: 1 lymph node candidate A6: 1 lymph node candidate B. The second container is additionally identified as, "bladder, prostate, left and right vas deferens". Received fresh and placed in formalin is a 250 g, 12.5 x 7 x 6 cm cystoprostatectomy specimen consisting of a 8.5 x 6.5 x 3 cm bladder with attached mesenteric fat and a detached 3.2 x 2 x 1.7 cm probable tumor (or
+
+--- Page 4 ---
+prostate). The right seminal vesicles and right vas deferens are not clearly identified and a structure resembling the right seminal vesicles measure 1.5 x 1.5 x 0.4 cm and there is no identifiable right vas deferens structure. The left vas deferens is not clearly identified and the left seminal vesicles measures 2.5x 1.5 x 0.4 cm and a structure resembling the left vas deferens measures 3 x 0.4 cm. The right ureteral stump measures 0.6 x 0.4 cm end. demonstrates an intact, patent lumen. The left ureteral stump is absent and the 1eft ureteral resection margin is taken where the ureter enters the bladder and is submitted as B3. The right half of prostate and bladder is inked blue and the left half is inked black. The bladder and prostate are opened anteriorly along the urethra. The fragments of the outer surface of the tumor fragment are white-brown and shaggy. Sectioning demonstrates a diffuse, homogenous, ill-defined, firm, white-tan. The opened bladder reveals a 1.8 x 1.2 x 0.3 cm raised, soft, red-pink lesion on the anterior wall designated as lesion #1, a 4 x 1.8 x 0.3 cm raised, soft, red-pink lesion on the inferior posterior wall and right inferior lateral wall designated as lesion #2, a 2.5 x 2.5 cm left posterior wall hemorrhage, and a 1.4 x 1 x 0.2 cm raised, soft, red-pink lesion on the mid left lateral wall designated as lesion #3. There is also an aggregate of firm, white-tan tumor fragments, free floating within the bladder lumen and measuring 11 x 5 x 3 cm. On cut section, lesion #1 extends into the muscularis propria and grossly into the perivesical tissue and is close to the deep margin. On cut section, lesion. #2 does not extend beyond the mucosa, and lesion #3 does not extend beyond the  mucosa and is 1.0 cm from the deep margin. There is a 0.6 x 0.5 x 0.5 cm rubbery, white-tan, mass which is in the muscle layer of the left lateral anterior wall and extending into the perivesicular adipose tissue. The surrounding bladder mucosa is edematous, wrinkled, congested, pink-tan with a uniform 0.1-0.2 cm wall thickness. Bilateral ureteral orifices, adjacent to the trigone, are identified and probe patent. Representative sections are submitted as follows: B1: Right ureter resection margin B2: Distal prostatic urethral margin B3: Left ureter resection margin (insertion into the bladder B4-B10: Representative right and left of probable tumor (rule out prostate) B11-B13 Lesion #1 (closest to deep margin B13) B14-B16 Lesion #3 (closest to deep margin B16) B17-B19: Lesion #2 B20: Uninvolved bladder mucosa bladder dome B21: Uninvolved bladder mucosa anterior wall B22: Uninvolved bladder mucosa posterior wall
+
+--- Page 5 ---
+B23: Uninvolved bladder mucosa trigone B24: Uninvolved bladder mucosa right lateral wall B25: Uninvolved bladder mucosa left lateral wall B26: Possible tumor deposit 0.3 cm from deep margin B27: Representative vas deferens and seminal vesicles B28-B30: Representative free floating tumor fragments B31-32: Additional free floating tumor fragments B33-B38: Additional possible prostate B39-B44: Additional free floating tumor fragments C. The third container is additionally identified as, "Right pelvic lymph node". Received in formalin is an aggregate of yellow-tan, soft, and lobulated. fiber adipose tissue fragments ranging in size from 1-1.5 cm. The specimen is. dissected to reveal for lymph node candidates ranging from 0.5-1.5 cm in greatest dimension. The lymph node candidates are submitted as follows:. C1-C3: 1 lymph node candidate, bisected (each cassette) C4: 1 lymph node candidate xXX {} mD See Tss's 4x AiscFepaNcy FoRM StaHnq thi5 -DQ fr hishhy pw BtR bt pamatogist. Iw 12h0f12 Jretr I btedde ZOH
+
+--- Page 6 ---
+TCGA Pathologic Diagnosis Discrepancy Form V4.00 Instructlons: The TCGA Pathologic Diagnosis Discrepancy Form should be completed when the pathologic diagnosis documented on the initial pathology report for a case submitted for TCGA is inconsistent with the diagnosis provided on the Case Quality Control Form completed for the submitted case.e Tissue Source Site (TSS) TSS Identifier: TSs Unique Patient Identifier: . Completed By (Interviewer Name on OpenClinica): _ Completed Date: Diagnosis Informatioa Data Element Entry Alternatives Workng Instructions I nvasiue peworhy dijfeutnte Provide the diagnosis/ histologic subtype(s) documented ond Pathologic Diagnosis the initial pathology report for this case. if the histology ford Provided on Initia! this case is mixed, provide all Hsted subtypes. osteeclas+-1:k gia=t cells rich  Pathology Report Drohedu& sassinone Histologic features of Provide ths histologic features selected on the TCGA Case  the sample provided muscle invasive urothelial carcinoma Quality Control Form completed for this case. for TCGA, as reflected  on the CQCF. Discrepancy between Pathology Report and Case Quality Control Form Provide the reason for. 3 Provide a reason describing why the diagnosis on the initiald the discrepancy Thx tumos ,s all pathology report for this case is not conslstent with the  between the pathology diagnosis selected on the TCgA Case Quality Control Form. report and the TCGA Mvsck tnvas:ue v5oHel;aI Case Quality Control Form. Car cinoma,hyL jrede with morphwlogically Variast Features. Name of TSS Reviewing Provide the name of the pathologist who reviewed this case Pathologist or for TCGA.  Biorepository Director has been quatity controlled. T'ss Reviewing .. olog.s. or Biorepository Director Date I acknowiedge that the above information provided by my instituton is true and correct and has been quality controlled. The Attending Pathologist or the Department Chairman has been informed or is aware of the above discrepancy in dkagnoses. Principal Investigator Signature Date
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+
+--- Page 1 ---
+1c0-0 -3 UUID: 8DECB6DA-5F5F-4475-A601-5252BC4BD486 8140/3 TCGA-DM-A1DA-01A-PR Redacted Gienocartinoms, Nos Sip Cod: Cecum C18.0 (First Tumor) Tumor Site: Cecum Proximal : Date of Cancer Sample Procurement: Histology: Adenocarcinoma Description of other histology:. Grade: Moderately Differentiated C Yes Mucinous: 6 No C Yes C Unknown (Focal) r Yes Signet Ring Feature: 6 No C Yes ^ Unknown (Focal) Histologic Heterogeneity:  No  Yes c Unknown Host Response: Lymphoid Aggregates Crohn's like reaction r None  Yes C Unknown Plasma cell rich stroma C No C Yes C Unknown Growth Pattern:  Expansile C Expansile  Invasive r Unknown  and Invasive Inflammatory Bowel Disease r^ No C Yes  Unknown Angiolymphatic Invasion: C No  Yes C Unknown Mutator Phenotype: 6 No C Yes C Unknown Number of Slides 1 C No  Yes Garland Necrosis present:. C Yes C Unknown (Focal) TIL Cells/ HPF 2.6 Pathologist Comment:e no nl mucosa mostly ade.
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diff --git a/output/text/8f2d8977-0d31-432e-87b2-09fc28a91e19.txt b/output/text/8f2d8977-0d31-432e-87b2-09fc28a91e19.txt
new file mode 100644
index 0000000000000000000000000000000000000000..96277514780fc216e84f372ca917958160ae38d8
--- /dev/null
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+Ic.s - 0 - 3 Site: busst, Nos C50.9 pws y/1/11 Procurement Date Laterality:Right, lower outer quadrant Path Report:BREAST TISSUE CHECKLIST Specimen type: Radical mastectomy Specimen size: Not specified Tumor site: Breast Tumor size: 2.2 x 1.8 x 1.8 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinoma Histologic grade: Moderately differentiated Tumor extent: Not specified Lymph nodes: 0/2 positive for metastasis (Regional 0/2) Extracapsular invasion of the lymph nodes: Not specified Margins: Not specified Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified UUID: BC3061B7-9C99-4270-84EE-B1306FA01AE2 Mitotic count (25x): Not specified TCGA-E9-A22A-01A-PR Redacted Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None
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diff --git a/output/text/8f678129-b1fe-49ca-a119-8424c2f09d97.txt b/output/text/8f678129-b1fe-49ca-a119-8424c2f09d97.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2512a1ea8e6e806609556664113c4843073f7f2f
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+DIAGNOSIS (A) RIGHT KIDNEY AND ADRENAL GLAND: RENAL CELL CARCINOMA (10.O CM MAXIMUM DIMENSION), CONVENTIONAL TYPE (70% CLEAR CELLS, 30% EOSINOPHILIC CELLS), FUHRMAN NUCLEAR GRADE 3, CONFINED TO THE KIDNEY. (SEE COMMENT). Margins of resection free of tumor. Adrenal gland, no tumor present. (B) GONADAL VEIN RIGHT: Blood vessels and fibroadipose tissue, no tumor present. COMMENT The renal cell carcinoma in the right kidney appears to be confined to the kidney and does not invade into the perinephric adipose tissue or the renal vein. The tumor pushes against the renal sinus but there is no unequivocal invasion into the renal sinus adipose tissue. Multiple additional deeper sections were also examined. GROSS DESCRIPTION (A) RIGHT KIDNEY AND ADRENAL GLAND - A radical nephrectomy specimen (23.0 x 14.0 x 9.5 cm) with a kidney (14.0 x 9.0 x 9.0 cm) and adrenal gland (6.0 x 2.5 x 2.0 cm). The kidney reveals a 10.0 x 8.5 x 8.5 cm tumor within the upper pole. The tumor is close to the Gerota's fascia and perinephric fat in focal areas (0.6 cm nearest). The tumor is also close to the pelvicalyceal system and the renal sinus. The renal vein and ureter are unremarkable. The tumor reveals overall pale yellow lobular surface with focal areas of hemorrhage, and myxoid degeneration centrally. The rest of the kidney and adrenal gland is unremarkable. Tumor is submitted for the vaccine protocol. INK CODE: Black - Gerota's fascia. SECTION CODE: A1-A3, tumor closest to Gerota's fascia; A4-A9, tumor close to the renal sinus; A10-A14, different areas of the tumor; A15, representative sections of the adrenal gland; A16, representative section from kidney; A17, renal vein and ureter. (B) GONADAL VEIN RIGHT - A single unoriented fragment of tissue measuring approximately 10.0 x 3.0 x 0.3 cm. The vein is identified and shows no evidence of tumor thrombi or other abnormalities. The surrounding soft tissue shows focal hemorrhage but otherwise unremarkable. SECTION CODE: B1-B3, representative sections. CLINICAL HISTORY Right renal mass. SNOMED CODES T-71000, M-83123
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diff --git a/output/text/8f96beda-e219-46fb-88b0-04e0e7e6601a.txt b/output/text/8f96beda-e219-46fb-88b0-04e0e7e6601a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..12245ade5f30da7b1324ead4225bb807b0f82999
--- /dev/null
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+
+--- Page 1 ---
+1C0-0-3 Carcinoms mifiHtnatwj ductal Nos 85os/3 Site; brast; Nos C50.9 IRB APPROVED Clinical Case Report (For Collection of Cancerous Tissue) UUID:4DAF6DB8-5429-4839-B103-D4317166D05B TCGA-C8-A1HM-01A-PR Redacted Informed Consent I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician of Study Coordinator ouature Date Clinical Information CSNGENERABNEORMATION Date of Birth (mm/dd/yyy) Height Marital Status Race Temperature m 5H  Single   Married Y Gender Weight  Divorced  Widow  Blood Pressure Heart Rate  Male 127 Female FSMANMTHISTORYOEPRESENTIELNESS Symptoms: Performance Scale (Karnofsky Score):.  100 Asymptomatic   80-90 Symptomatic but Fully Ambulatory  60-70 Symptomatic, in bed less than 50% of day  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden.  20-30 Bed Ridden RCURRENTMEDICATIONS Drug Dose Route Frequency Date (mm/dd/yyyy) 1 To To To To To /
+
+--- Page 2 ---
+PAST MEDICAL HISTORY Diagnosis/Disease/Disorder/Injury Diagnosis Date Treatment Status  CFSOB/GYNHISTORY  Menopausal Statusd Date of First Menses. # of Pregnancies  Pre-menopausal Dor'ta&eremhe  Peri-Menopausal Date of Last Menses # of Live Birthsd  Post-menopausal Dotaoemh Birth Control:  Condom  Oral Contraceptive   IUD  Hormone Replacement  Other: Therapy: Occupation: Environmental Hazards: Smoking History Current Status TYPE Packs/day Duration When Quit  yes ~@NO (yrs)} (yr) Alcohoi Consumption Current Status TYPE Drinks/day Duratlon When Quit  yES PNO (yrs) (vr) Drug Use Current Status TYPE Duration When Quit Freguency  yES FNO (yrs) (yr) HIRTRCFAMILYMEDICALHISTORYAWW  Relative Diagnosis Age of Diagnosis NLABDATAS Test Date Test Result Result Date CEA  Negative  Positive: HIV Negative  Positive: CA 15-3 Hep B Negative   Negative  Positive:  Positive: Hep C Negative CA 19-9   Negative  Positive:  Positive: AFP  Negative  Positive: PSA   Negative  Positive: Other: Other:  Negative  Positive:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+ +A W*  DIAGNOSTIC STUDIES    s  3: Study Results Date Ultrasound X-Ray CT Endoscopy MRI Biopsy V heart samse  Preoperative Clinical Diagnosis Location of Suspected Invoived Lymph Nodes Location of Suspected Distant Metastasis Clinical Staging Date of Diagnosis T2 NO MO Stage: II Treatment Information KASURGICALTREATMENTAAA* Procedure Date of Procedure Modibied.Kadica?. Primary Tumor Organ Detailed Location Size tuecorut eosT Lee 3 x<sx cm Extension of Tumor. Lymph Nodes Description Locatlon of Lymph Nodes # of Lymph Nodes Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Organ Detailed Location Size Surgical Staging T2NOMa Stage:_j  NEOADJUVENTTHERAPY (Chemo, Radiation Immuno, Hormonal, or Molecular) Drug/Treatment Dose Route Frequency Date (mm/dd/yyy) To To 1 To 1 To 1 1 To 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by: Date: me. Preserved by: Date Time: SPECIMENTYPE (#ofsamples provided) Paraffin Block  Biood/Serum/Piasma Slide Frozen Normal Diseased Normal Diseased Normal Diseased  Normal Diseased 4f 2 4 2 2 Time to LN2 Time to Formalin Time to LN2 min min 2 min /3 AARSPATHOLOGIGALDESCRIPTIONAYTAA Primary Tumor Organ Size Extension of Tumor Distance to NAT Baexe! Tuwek. 2 x Le 2Cx. cm cm Lymph Nodes Location # Examined # Metastasized Distant Metastasis Organ Detailed Location Size Pathological Staging N o M d Stage: pT Z Notes: 4
+
+--- Page 5 ---
+CONSOLIDATED DIAgNOSTIC PAThOLOgy fORm* Microscopic Appearance: 1. Histological pattern: CELL DISTRIBUTION Diffuse STRUCTURAL PATTERN Mosaic A Streaming Necrosis Storiform Lymphocytic Infiltration Fibrosis Vascular Invasion Palisading  Cystic Dereneration Clusterized Alveolar Formation X. Bleeding Indian File Myxoid Change 2. Cellular features: Psammoma/Calcification Sgwamous + Adenomatous Squamoid Cell t: Sarcomatous Glandutar cel! + Lymphomatous 1 Round Cell Spindlk Cell Cell Stratificatioa  Lare Ceu 1 Fibroblast Keratin Small Cent Secretion X Osteoblast  Desmosome RS CelV/RS Like Intracyt. Vacuole Lipoblast Inflan. Cell Pear! Giand formation XMyoblast Piasma Celt Otherwise Specified: D 3O7s Dz5%(+Neurn3oZ) B 75Z Dg7t% 2.Cellular Differentiarion: Ve(Rrsxs 29] Well Modermcly Poor Nxclear Atypia: Nuckar Appearance  Aniso Nucleosis Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell yey  Mitotic Activity Nuckear Grade Histological Diagnosis:Inhiltra hry ldaeta Cat rmg Nos G- 3 InmAaenibi : sojeered M, Mr. Comments: Date Director, Research Pathology i' STAFF FOR RESEARCH USE ONEY). *(INTEGRATED REPORT OF FINDINGS BY CON
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diff --git a/output/text/8f9ff5ab-99b0-461a-bab1-deccc18c5ce5.txt b/output/text/8f9ff5ab-99b0-461a-bab1-deccc18c5ce5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5c7aff3070e30663db944ffb35c735778c2177f3
--- /dev/null
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+
+--- Page 1 ---
+Result Typet Surgical Pathology Report D-0 -3 Resuit Dates Cereenrio, ysaplfory Performed By: 80k0J3 Encounter info: nsnal clL Surgical Pathology Report Cle4t J 8/913 Surgical Pathology Report DIAGNOSIS: A. Posterior medial margin: Renal cortical tissue.  Negative for malignancy B. Tuor base $l: Negative for malignancy. c. Tumor base #2: Renal cortical tissue.  Negative for malignancy. D. Left kidney tumor, excision: Renal cell carcinoma, papillary type, 2.0 cm in greatest dimension, Fuhrman nuclear grade 1 (of 4) The tumor focally abuts the inked margin.  No invasion of adipose tissue is identified. UUID: 3CFF32CE-20A4-4D1D-B338-8845CF9F86E6 TCGA-SX-A71S-01A-PR Redacted CLINICAL INFORMATION: Left perihilar nass. w.74]13 ite SPECIMEN (S) : A:Posterior medial margin B:Tumor base  C:Tumor bas #2 D:Laft kidney tumor PRELIMINARY INTRAOPERATIVE DIAGNOSIS: Intraonerative Patholoaist(s): rosterior mealas margin, frozen section diagnosis: Negative. B. Tumor bage #l, frozen section diagnosis: Negative. Tumor bass $2. frozen section diagnosis: Negative. D. Left kidney tumor, frozen section diagnosis:  Renal neoplasm. Favor papillary renal cell carcinoma, type l versus less likely wetanephric adanoma. Tumor cells are at ink. GROSS DESCRIPTION: Performed by A. Received fresh labeled and "posterior medial margin" is a.tan portion of tissue, 0.3 x 0.3 x 0.1 cm. A11 B. Received fresh labeled and "tumor base tl" is a tan portion of tissue, 0.4 x.0.3 x 0.2 A11  submitted following frozen section in one cassette labelad -B1. C. Received fresh labeled and "tumox base #2" is a. portion of tissue, 0.4 x 0.2 x 0.Z cm. frozen section in on. cassette labeled Received fresh labeled and rleft kidney tumor" is - spherical nodule, 2.0 cn in greatest dimension. There is a portion of lobulated soft fat that is present on the surface opposite the inked base. The cut surfaca of the nodule has uniform, pale yellow consistencv throughout. All submitted in four cassettes labeled Dl) Frozen section sample; D2-D3) remainder or tuauss ana adjacent fat; D4) mirror image of sanple submitted for r-gearch Support for th. diagnosis in this case may have included the use of innunohistochenistry tests that were develooed and whose performance characteriatirs vere detezmined by They have not been cieared Or approvea oy cnw u.s. Food ana Drug Administration (FDA). The FDA has determined that such clearance or approval is not necessary. These tests should not be regarded as investigational or for rasearch. This laboratory is certified under the Clinical Laboratory Improvement Amendments of l99s ('cLIA') as qualified to perform high complaxity clinical laboratory testing.
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diff --git a/output/text/8fb7733b-5f20-4e83-a1c4-16a5920e3f56.txt b/output/text/8fb7733b-5f20-4e83-a1c4-16a5920e3f56.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5a93e9d23532a08fc02a8e9d4546720ad01fd414
--- /dev/null
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+
+--- Page 1 ---
+1cs-0-3 Carcn oma,hfi1rru+q duct,Nos85oo/3 Poth 1s/aifu h CQcF Site: hust Nos c5o.9 Final Diagnosis. Breast,left ypper inner quadrant, lumpectomy: Infiltrating ductal carcinoma, with medullary like. features, Nottingham grade III (of III), [tubules 3/3, nuclei 3/3, mitoses 2/3; Nottingham score. 8/9], forming a 2.7 x 2.5 x 2.0 cm yellow-tan, somewhat circumscribed, sclerotic mass. [AJCCpT2]. Ductal carcinoma in situ is absent. Angiolymphatic invasion is absent. All surgical resection margins, after re-excision of the deep and medial inferior margins, are negative for. tumor (minimum tumor free margin, 0.8 cm, deep margin).. Lymph node, left axillary, sentinel biopsy: A single (1) left axillary sentinel lymph node is. negative for tumor, confirmed by cytokeratin (AE1/AE3) immunostains. ER/PR and Her2/neu have been ordered on paraffin-embedded tissue. UUID:B8485405-199C-48C7-96D7-8C315DEA6684 TCGA-AR-A1AW-01A-PR Redacted
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diff --git a/output/text/8ff21ff7-49c8-4478-b81d-c213b2f5f662.txt b/output/text/8ff21ff7-49c8-4478-b81d-c213b2f5f662.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6c14e5d5461ae0b2f83ef4ca05a950092ba46b26
--- /dev/null
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+--- Page 1 ---
+*** Diagnosis / Diagnoses: *** Right hemicolectomy specimen with an ulcerated colon carcinoma conforming to the histological type of a moderately differentiated colorectal adenocarcinoma, located 1 cm aborally from Bauhin's valve and measuring 4 cm at its greatest diameter. Invasive spread of tumour into the outer layers of the muscularis propria. Oral and aboral resection margins and large omentum tumor-free. Twelve mesocolic and mesenteric tumor-free lymph nodes, with uncharacteristic reactive changes. Tumor stage is therefore pT2 pN0 (1/12), L0, V0; G2,
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diff --git a/output/text/90049a40-9c67-4801-a280-63e9187728a9.txt b/output/text/90049a40-9c67-4801-a280-63e9187728a9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0253f2aabd733ff4b92e7c275ba50ecce967f461
--- /dev/null
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+
+--- Page 1 ---
+Diagnosis: Resected section of colon (sigma) with a colon carcinoma characterized histologically as a moderately differentiated colorectal adenocarcinoma, extending up to 5 cm to one resection margin and measuring 4.5 cm in diameter at the widest point. Invasive spread of the tumor within all intestinal wall layers up to the bordering mesocolic fatty tissue and the level of the subserosa. In addition, the colon wall has a few pseudodiverticula and slightly scarring. peridiverticulitis. The stage of the tumor is therefore: pT3 pN0 (0/22) L0 V0; G2 R0..
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diff --git a/output/text/9028d496-147d-49e2-8a6d-9233b34810e3.txt b/output/text/9028d496-147d-49e2-8a6d-9233b34810e3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c1c6827f9fa49dd43a719ea00de2ce75a3f43c94
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+SURGICAL PATHOLOGY REPORTS clinical Diagnosis & History:  year old female with colorectal carcinoma. Specimens Submitted: 1: Right hemicolectomy DIAGNOSIS: 1. Right hemicolectomy: Tumor Type: Adenocarcinoma Histologic Grade: Moderately differentiated Tumor Location: Cecum Tumor Size: Length is 3 cm Width is 3.4 cm Maximal thickness is 1.1 cm. Tumor Budding: Focal Increased Tumor Infiltrating Lymphocytes: Absent Precursor Lesions: Tubulovillous adenoma Deepest Tumor Invasion: Subserosal adipose tissue and/or mesenteric fat Gross Tumor Perforation:. Not identified Surgical Margins: Free of tumor Polyps/Mucosa Dysplasia (away from the carcinoma): Not Identified Non-Neoplastic Bowel: Unremarkable Appendix: Not identified Lymph Nodes: Number with metastasis: 4. Total number examined: 17 Tumor deposits in pericolorectal soft tissue: ** Continued on next page **
+
+--- Page 2 ---
+Page 2 of 3 Not Identified Tumor Staging (AJcc 7th Edition): pT3 (Tumor invades through the muscularis propria into pericolorectal tissues) Lymph Node Stage (AJcc 7th Edition):. N2a (Metastasis in 4-6 regional lymph nodes). I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Gross Description: 1). The specimen is received fresh, labeled "Right hemicolectomy" and consists of a segment of terminal ileum, cecum with attached appendix and ascending colon. The terminal ileum measures 11.5 cm in length and 3.0 cm in circumference at the proximal resected margin.. The remaining colon measures 20.0 cm in length with a circumference of 7.0 cm at the distal resected margin. There is no attached appendix, and serosa displays a 0.7 x 0.5cm white ill-defined fibrotic focus of a possible previous appendectomy site which is submitted.  The intestinal serosa is pink tan and smooth.. Focally hemorrhagic lobulated yellow tan adipose tissue spans the length of the  specimen measuring up to 4.5 cm. thickness. The specimen is opened to reveal a papillary tumor measuring 3.0 Cm in length and 3.4 Cm in width. The tumor is located distal to the cecum, 3.2cm from the ileocecal valve, l4.8 cm from the proximal margin and 15.0 cm from the distal margin. Sectioning shows that the tumor invades to a depth of 1.lcm grossly extending into the muscularis.  The remaining mucosa is otherwise tan yellow and grossly. unremarkable. The attached adipose tissue is thoroughly examined and all identified lymph nodes are submitted. Representative.  sections of the specimen are submitted for permanent sections and for Summary of sections: PM - proximal margin shave DM - distal margin shave T - tumor A-I possible previous appendectomy site. RS -representative sections. LN - lymph nodes BLN - bisected lymph nodes ** Continued on next page **.
+
+--- Page 3 ---
+Page 3 of 3 Part 1:  Right hemicolectomy Blocke Sect. Site. PCs 127113 DM PM RS T ** End of Report
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diff --git a/output/text/90574fd5-25d1-4352-a6f9-f4e431b1c37f.txt b/output/text/90574fd5-25d1-4352-a6f9-f4e431b1c37f.txt
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index 0000000000000000000000000000000000000000..0bacb9fb94502db9f3663ff2106663669146c670
--- /dev/null
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+
+--- Page 1 ---
+FINAL DIAGNOSIS: PARt 1: Lymph nODe, LEft BREASt, #1 SEntineL, EXcISIOn -  NO EVIDENCE OF METASTATIC MAMMARY CARCINOMA IN ONE LYMPH NODE (0/1). PART 2: Lymph nODE, LEft BrEASt, #2 SEnTIneL, EXCiSIOn --  NO EVIDENCE OF METASTATIC MAMMARY CARCINOMA IN ONE LYMPH NODE (0/1). Part 3: Breast. Left, Segmental mastectomy -- A. Inyasive Ductal Carcinoma. B.  NOTTiNGHAM GRADE T (TUBULE fORMATiON: 2, NUCLEAR PLEOMORPHISM: 2, mITOTIC ACTIVITY: 1; Total ScoRe 5/9). C. INVASIVE TUMOR MEASURES 1.8 CM IN LARGEST DIMENSION. D.  NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED.  INVASIVE CARCINOMA IS 0.8 CM FROM THE NEAREST ANTERIOR MARGIN. SYNOPTIC - PRiMARY INVASIVE CARCiNOMA OF BREAST LATERALITY: PROceDUrE: Left Segmental LOcATION: Not specified SIZE OF TUMOR:  Maximum dimension invasive component: 1.8 cm  MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: TUMOR TYPE (invasive component): No 1cs-0-3 Ductal adenocarcinoma, NOS  NOTTINGHAM SCORE: Cavcnomu, inpiltrutvg duchf nos 8500f3 Nuclear grade: 2 Tubule formation: 2 Sih:brst,Nos C5o.9 3f3fn p Mitotic activity score: 1 Total Nottingham score: 5 Nottingham grade (1, 2, 3): 1 ANGIOLYMPHATIC INVASION: No DERMAL LYMPHATIC iNVASION: No CALCIFICATION: No SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No Distance of invasive tumor to closest margin: 8 mm PAGET'S DISEASE OF NIPPLE: LYMPH NODES POSITIVE: No LyMPH NODES EXAMINED: 0 METHOD(S) OF LYMPH NODE EXAMINATION: 2 H/E stain SENTINEL NODE METASTASIS: No NON-NEOPLASTIC BREAST TISSUE: FCD t StAge, PAThOlOgIC: UUID:EB09D890-879C-4874-AE3F-47E41C2C66FE pT1c N Stage, patholOgIC: TCGA-BH-A0B0-01A-PR Redacted M Stage, PathologIC: pN0 ESTROGen ReCepTORS: pMX PROGESTERONE RECEPTORS: positive positive HER2/NEU: zero or 1+ 3/+3/++
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diff --git a/output/text/908a8c1a-70a9-4fcb-8f2b-6edec7f40f47.txt b/output/text/908a8c1a-70a9-4fcb-8f2b-6edec7f40f47.txt
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index 0000000000000000000000000000000000000000..a8e9729f94698e28b0cdcc7f180d902801aa2dfa
--- /dev/null
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+
+--- Page 1 ---
+Clinical Diagnosis & History: ' Right multicentric IDC and ILC presents for bilateral TM, bilateral sLNBx.. Specimens Submitted: 1: sp: Sentinel node #1 level 1 left axilla 2:SP: 9 Sentinel node #2 level 1 left axilla SP: Sentinel node #1 level 1 right axilla (fs) 4: SP: Sentinel node #2 level 1 right axilla (fs) 5 : Sp: Right breast and axillary contents level 1, 2, and 3 6: SP: 1 Left breast 7: Sp: Right rotter's node 8: Sp: Additional level 1 lymph right axilla node 1 UUID:2E8A1816-E963-4063-B2F0-6289514084A5 9: sp: Additional right level 2 axillary contents TCGA-AO-A03A-01A-PR 10: SP: Level 3 lymph node right axilla  Redacted DIAGNOSIS: 1) SENTINEL NODE #1 LEVEL 1 LEFT AXILLA; EXCISION: - ONE BENIGN LYMPH NODE (O/1. 2) SENTINEL NODE #2 LEVEL 1 LEFT AXILLA; EXCISION: - ONE BENIGN LYMPH NODE (O/1). 3) SENTINEL NODE #1 LEVEL 1 RIGHT AXILLA; EXCISION: - METASTATIC CARCINOMA INVOLVING ONE OF ONE LYMPH NODE (1/1). - THE METASTATIC CARCINOMA IS PRESENT AS SUB-CAPSULAR TUMOR CELL CLUSTERS MEASURING <0.2MM AND COMPOSED OF 30-40 CELLS. THE TUMOR CELLS ARE SEEN BOTH IN THE HE STAINED AND KERATIN (AEI:AE3) IMMUNOSTAINED SECTIONS. 4) SENTINEL NODE #2 LEVEL 1 RIGHT AXILLA; EXCISION: - METASTATIC CARCINOMA INVOLVING ONE OF ONE LYMPH NODE (1/1). - THE METASTATIC FOCUS MEASURES 1.2 CM, WITH EXTRANODAL EXTENSION (>2MM). 5) BREAST, RIGHT; MASTECTOMY: TUMOR #1: - INVASIVE DUCTAL CARCINOMA, WITH FOCAL LOBULAR GROWTH PATTERN, HISTOLOGIC GRADE II/III (MODERATE TUBULE FORMATION). NUCLEAR GRADE II/III (MODERATE VARIATION IN SIZE AND SHAPE), MEASURING ~3.6 CM IN LARGEST DIMENSION GROSSLY. ** Continued on next page ** 1c0-0-3 carcmomna vifilt^aHng duct, Nvs 85oof3 w icf2yjn 9/24/+1
+
+--- Page 2 ---
+- DUCTAL CARCINOMA IN-SITU (DCIS) IS ALSO IDENTIFIED, MICROPAPILLARY TYPE  Page 2 of 8 WITH INTERMEDIATE NUCLEAR GRADE AND MINIMAL NECROSIS.  THE DCIS CONSTITUTES LESS THAN OR EQUAL TO 25% OF THE TOTAL TUMOR MASS, AND IS PRESENT ADMIXED WITH THE INVASIVE COMPONENT. - THE INVASIVE CARCINOMA IS LOCATED IN THE UPPER INNER QUADRANT, AT 1:00. THE DCIS IS LOCATED IN THE UPPER INNER QUADRANT. - NO INVOLVEMENT OF THE NIPPLE BY EITHER IN SITU OR INVASIVE CARCINOMAS IS IDENTIFIED. - NO CALCIFICATIONS ARE IDENTIFIED IN EITHER THE INVASIVE OR IN SITUS COMPONENT. - EXTENSIVE VASCULAR INVASION IS PRESENT - NO INVOLVEMENT OF THE SURGICAL MARGINS BY EITHER INVASIVE OR IN SITU CARCINOMA IS IDENTIFIED. - INVASIVE CARCINOMA IS 3.3 CM FROM THE DEEP MARGIN GROSSLY. TUMOR #2: - INVASIVE DUCTAL CARCINOMA, NOS TYPE, WITH FOCAL LOBULAR GROWTH PATTERN, HISTOLOGIC GRADE II/III (MODERATE TUBULE FORMATION), NUCLEAR GRADE II/III (MODERATE VARIATION IN SIZE AND SHAPE), MEASURING 2.5 CM IN LARGEST DimensIon grossLy.  DUCTAL CARCINOMA IN-SITU (DCIS) IS ALSO IDENTIFIED, SOLID, CRIBRIFORM TYPE WITH INTERMEDIATE NUCLEAR GRADE AND MODERATE NECROSIS. LOBULAR INVOLVEMENT BY DCIS IS PRESENT. - THE DCIS CONSTITUTES LESS THAN OR EQUAL TO 25% OF THE TOTAL TUMOR MASS, AND IS PRESENT ADMIXED WITH THE INVASIVE COMPONENT. - THE INVASIVE CARCINOMA IS LOCATED IN THE LOWER INNER QUADRANT AT 5:00. THE DCIS IS LOCATED IN THE LOWER INNER QUADRANT. INVOLVEMENT OF THE NIPPLE BY EITHER IN SITU OR INVASIVE CARCINOMA ISS -NO IDENTIFIED. - CALCIFICATIONS ARE PRESENT IN THE INVASIVE CARCINOMA ONLY. VASCULAR INVASION IS PRESENT. - NO INVOLVEMENT OF THE SURGICAL MARGINS BY EITHER INVASIVE OR IN SITU CARCINOMA IS IDENTIFIED. - INVASIVE CARCINOMA IS 4.5 CM FROM THE DEEP MARGIN GROSSLY - THE NON-NEOPLASTIC BREAST TISSUE SHOWS USUAL DUCTAL HYPERPLASIA, PAPILLARY APOCRINE HYPERPLASIA, COLUMNAR CELL CHANGE, AND CYSTS. - THE LYMPH NODE STATUS IS AS FOLLOWS (EXPRESSED AS THE NUMBER OF POSITIVE LYMPH NODES IN RELATION TO THE TOTAL NUMBER OF LYMPH NODES BXAMINED) : 13/17. - THERE IS EXTRANODAL EXTENSION (>2mm) OF CARCINOMA. THE LARGEST METASTATIC CARCINOMA MEASURES 1.1CM. - RESULTS OF SPECIAL STAINS (ER, PR, HER2-NEU) ARE AS FOLLOWS: TUMOR 1: ESTROGEN RECEPTOR 90% nuclear staininy wil" Oderate intensity PROGESTERONE RECEPTOR 1: <5% nuclesr at-'-- ' weak intensity HER2 Negative ( 1+) (<io% of invasive tumor cells exhibit weak complete membranous staining; Uniformity of staining: absent; Homogeneous, dark circumferential pattern: absent). TUMOR 2: ESTROGEN RECEPTOR  50-60% nuclear staining with moderate intensity. * Continued on next page **
+
+--- Page 3 ---
+Page PROGESTERONE RECEPTOR : Of8 10-20% nuclear staining with moderate intensity. Negative ( 1+) (<i0s of invasive tumor cells exhibit weak complete membranous staining; Uniformity of staining: absent; Homogeneous, dark circumferential pa' ahsent) Comment: Controls are satisfactory. 8 PATHWAY anti-HER-2/neu is an FDA-approved rabbit monoclonal primary antibody (clone 4b5) directed against the internal domain of the c-erbB-2 oncoprotein (HeR2) for. immunohistochemical detection of HEr2 protein overexpression in breast cancer tissue routinely processed for histologic evaluation. The HeR2 test results are reported in accordance with the Asco/cAp guideline recommendations for HER2 testing in breast cancer (J Clin Oncol 2007; 25(1) :118-145). The ER and PR rabbit monoclonal antibodies are also FDA approved. 6) LEFT BREAST; MASTECTOMY: - BENIGN BREAST WITH PAPILLARY APOCRINE HYPERPLASIA, USUAL DUCTAL HYPERPLASIA AND COLUMNAR CELL CHANGE. - BENIGN NIPPLE.S 7) RIGHT ROTTER'S NODE; EXCISION: - METASTATIC CARCINOMA LARGELY REPLACING ONE OF ONE LYMPH NODE (1/1). THE METASTATIC FOCUS MEASURES O.9 CM, WITH NO EXTRANODAL EXTENSION. 8) ADDITIONAL LEVEL 1 LYMPH RIGHT AXILLA NODE I; EXCISION: - METASTATIC CARCINOMA INVOLVING THREE OF THREE LYMPH NODES (3/3). LARGEST METASTATIC CARCINOMA MEASURES O.3CM. EXTRANODAL EXTENSION IS PRESENT. 9) ADDITIONAL RIGHT LEVEL 2 AXILLARY CONTENTS; EXCISION: - METASTATIC CARCINOMA INVOLVING FOUR OF FOUR LYMPH NODES (4/4). LARGEST METASTATIC CARCINOMA MEASURES O.SCM. - EXTRANODAL EXTENSION IS PRESENT. 10) LEVEL 3 LYMPH NODE RIGHT AXILLA; EXCISION: - METASTATIC CARCINOMA LARGELY REPLACING ONE OF ONE LYMPH NODE (1/1). LARGEST METASTATIC CARCINOMA MEASURES O.2CM. - EXTRANODAL EXTENSION IS PRESENT. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. *** Report Electronically Signed Out *** Gross Description:. 1). The specimen is received for a canceled a canceled frozen section ** Continued on next page **?
+
+--- Page 4 ---
+consultation, placed in formalin labeled "Sentinel node number one level 1 - Page 4 of 8 left axilla" and consists of a 1.4 x 0.5 x 0.5 cm piece of lymphoid fatty tissue is bisected and entirely submitted.. Summary of sections: U - undesignated 2). The specimen is received for a canceled frozen section consultation, placed in formalin, labeled nSentinel node number two, level one left axilla" and consists of 1.3 x 1.3 x 0.5 cm pink-tan lymph node which is bisected and entirely submitted.. Summary of sections: U - undesignated 3). The specimen is received fresh for frozen section consultation, labeled "Sentinel node number one level 1 right axilla" and consists of a 0.4 x 0.4 section. Summary of sections: FSC -- frozen section control 4): The specimen is received fresh for frozen section consultation,. labeled "sentinel node number two level 1 right axilla" and consists of a 1.2 x 1.0 x 1.0 cm lymph node which is bisected and entirely submitted for frozen section. Summary of sections: FSC -- frozen section control 5) The specimen is received fresh labeled, "right breast and axillary. contents level 1,2, and 3" and consists of a breast with attached axillary contents.  The breast measures 19 x 18 x 6 cm with overlying skin ellipse measuring 18.5 x 7.5 cm.  Situated on the skin surface is a nipple measuring 1.5 x 1.5 x 0.5 cm and areola measuring 3.5 cm. Axillary contents measures 12 x 7 x 2.5 cm. The posterior surface of the The skin shows no scar. breast is inked black and the anterior blue. The specimen is serially. sectioned to reveal a mass (mass 1) measuring 3.6 x 3.01 x 2.5 cm, and located in the urg at 1 o' clock and 3.3 cm from the deep margin.. identified in the mass 1. Another mass (mass 2) measuring 2.5 x 2.2 x 1.5 cm A clip is. LIQ at 5 o' clock . located 4.5 cm from the deep margin is identified. The remaining breast tissue shows fibroglandular tissue.. dissected to reveal multiple lymph nodes. Representative sections are The axillary tissue is. ** Continued on next page **
+
+--- Page 5 ---
+ All dissected lymph nodes are.  Page 5 of 8 subnitted. entirely submitted. ' Surmary of sections: N - nipple NB - nipple base D1 - deep margin for mass 1. D2  deep margin for mass 2 T1 mass 1 T2 mass 2 UIQ upper i inner quadrant LIQ lower inner quadrant UOQ  - upper outer quadrant LOQ lower outer quadrant. LN lymph nodes M.D. 6) The specimen is received fresh labeled, "left breast" and consists of a breast measuring 25 x 18 x 5cm with overlying skin ellipse measuring 18 x 8. cm.  Situated on the skin surface is a nipple measuring 1.8 x 1.3 x lcm and areola measuring 3.5 cm. The skin is unremarkable. axillary aspect. A suture demarcates the  The posterior surface of the breast is inked black and the. axillary aspect is inked yellow. The specimen is serially sectioned to reveal unremarkable fibroglandular tissue without mass lesion. Sectioning of the axillary aspect reveals no grossly identifiable lymph nodes. Representative sections are submitted.. Summary of sections: N - nipple NB - nipple base deep margin UIQ - upper inner quadrant LIQ  lower inner quadrant UOQ - upper  outer quadrant LOQ - lower outer quadrant. 7). The specimen is received in formalin, labeled "Right Rotter' s node" and. consists of a single pink tan fleshy lymph node measuring 1 x 0.8 x 0.5 cm. The lymph node is entirely submitted. Summary of sections: LN- lymph node 8). The specimen is received in formalin, labeled "Additional level 1 lymph node,. right axilla" and consists of four pink tan firm lymph nodes ranging. from 0.4 to 2.2 cm in greatest dimension.. All identified lymph nodes are submitted. Summary of sections: LN -- iymph nodes BLN1-- bisected lymph node #1 ** Continued on next page **
+
+--- Page 6 ---
+BLN2' bisected lymph node #2 9). The specimen is received in formalin, labeled "Additional right level two axillary contents" and consists of a portion of yellow tan adipose tissue, with four pink tan firm lymph nodes ranging from 0.6 to 1 cm in greatest dimension. All identified lymph nodes are submitted.. Summary of sections:. LN -- lyuph nodes- 10). The specimen is received in formalin, labeled "Level three lymph node, right axilia" and consists of a single pink tan fatty lymph node measuring 0.8 x 0.3 x 0.2 cm. The lymph node is entirely submitted.. Summary of sections:. LN- lymph node. Summary of Sections:. Part 1: SP: Sentinel node #1 level 1 left axilla. Block Sect. site PCs 1 u 1 Part 2:  SP: Sentinel node #2 level 1 left axilla. Block Sect. Site PCs 1 1 Part 3: SP: Sentinel node #1 level 1 right axilla (fs). Block Sect. site PCs fsc 1 Part 4: SP: Sentinel node #2 level 1 right axilla (fs) Block Sect. Site PCs 1 fsc 1 Part 5: SP: Right breast and axillary. Block Sect. Site PCs 5 BLN 10 1 D1 1 1 D2 1 1 LIQ 1 5 LN 15 Continued on next page *
+
+--- Page 7 ---
+2 LOQ 2 1 1 1 3 T1 3 T2 3 UIQ 12 2 UOQ Part6: SP: Left breast Block Sect. Site PCs 1 D 1 2 LIQ 2 LOQ 2 1 N 2 1 NB 1 2 UIQ 2 UOQ Part 7: SP: Right rotter's node Block Sect. Site. PCs 1 LN 1 Part 8: SP: Additional level 1 lymph right axilla node 1 Block Sect. Site. pCs 1 bln1 2 2 bln2 2 1 LN 2 Part 9: Sp: Additional right level 2 axillary contents Sect. site Block pCs 1 LN 4 Part 10: SP: Level 3 lymph node right axilla Block Sect. Site. PCs 1 LN 1 Intraoperative Consultation:. Note:  The diagnoses given 'in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 3) FROZEN SECTION DIAGNOSIS: SP: SENTINEL NODE #1 LEVEL 1 RIGHTS BENIGN LYMPH NODE ( PERMANENT DIAGNOSIS: SAMES 4) FROZEN SECTION DIAGNOSIS: SP: SENTINEL NODE #2 LEVEL 1 RIGHT AXILLA FS):  METASTATIC CARCINOMA PERMANENT DIAGNOSIS: SAMES ** Continued on next page **
+
+--- Page 8 ---
+age The diagnoses given in this section pertain only to the tissue sample 3) FROZEN SECTION DIAGNOSIS: SP: SENTINEL NODE #1 LEVEL 1 RIGHT AXILLA (FS): BENIGN LYMPH NODE PERMANENT DIAGNOSIS: SAME 4) FROZEN SECTION DIAGNOSIS: SP: SENTINEL NODE #2 LEVEL 1 RIGHT AXILLA (FS) : METASTATIC CARCINOMA PERMANENT DIAGNOSIS: SAME End of Report.
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diff --git a/output/text/90c331ed-164b-4b96-9f93-aff2ebeb8b56.txt b/output/text/90c331ed-164b-4b96-9f93-aff2ebeb8b56.txt
new file mode 100644
index 0000000000000000000000000000000000000000..21d447309a5d4e2f170141748bce774e4f9f7e54
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+LARGE INTESTINE TISSUE CHECKLIST Specimen type: Excision of tumor Specimen size: Not specified Tumor site: Sigmoid colon Tumor size: 4 x 3 x 1 cm Tumor features: None specified Histologic type: Adenocarcinoma Histologic grade: Moderately differentiated Tumor extent: Pericolonic tissues Lymph nodes: 1/6 positive for metastasis (Intraabdominal 1/6) Margins: Uninvolved Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None
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diff --git a/output/text/90eeddbc-896a-4f84-b168-11a2d38ed69f.txt b/output/text/90eeddbc-896a-4f84-b168-11a2d38ed69f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..286058a5a7d2520de9b1c4a2bde799e007d28a20
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+DIAGNOSIS: 1. Lymph node, interaorta caval (excision): Lymph nodes, no tumor seen (0/2) 2.  Kidney and adrenal, right (nephrectomy and adrenalectomy): Renal cell carcinoma, chromophobe type, Fuhrman nuclear grade IlI. Tumor infiltrates the capsule but does not involve the inked margin. Vascular and ureteral margins are free of tumor. - Adrenal gland, no tumor seen. Kidney Nephrectomy Summary Table Macroscopic Specimen Type: Radical nephrectomy. Laterality: Right Tumor Size: 12 cm in greatest dimension. Focality: Unifocal Macro Extent of Tumor: Within inked margin Microscopic Histologic Type: Chromophone renal carcinoma Histologic Grade: Fuhrman nuclear grade III Extent of Invasion Primary Tumor(pT): T2 Regional Lymph Nodes(pN): NO Distant Metastisis(pM): MX  Patient Identification Page 1 of 3
+
+--- Page 2 ---
+Margins: Vascular and ureteral margins are free of tumor CLINICAL INFORMATION: Brief Clinical History: history of large 10cm upper pole renal mass. Tiny interaortocal node seen on CT scan PRocEDuRE: Operative Findings: Large mass with questionable involvement of. adrenal. Small node identified and removed I.A.C. Post-Operative Diagnosis: right renal mass Pre-Operative Diagnosis: right renal mass SPECIMENS SUBMITTED: 1. LYMPH NODES, Interaortocaval node 2. KIDNEY, RIGHT, and adrenal gland GROSS DESCRIPTION:  Received are 2 containers labeled with the patient's name, medical record number,. and further described as follows: 1.  "Interaorta caval node". The specimen consists of 2 firm yellow and tan nodules measuring 2.0 x 1.2 x 0.6 and 0.7 x 0.5 x 0.3 cm. Both nodules are bisected revealing a smooth tan cut surface. The specimen. is entirely submitted in a white cassette labeled . for permanent processing. 2. "Right kidney and right adrenal gland". The specimen is a radical nephrectomy specimen measuring 17 x 11 x 8 cm overall. The specimen is partially inked black and bivalved, revealing a brown tumor mass measuring 12 cm in largest dimension with a tan, soft cut surface and areas of necrosis. Approximately 3 x 1 x 0.5 cm in aggregate of the mass and approximately 1 x 1 x 0.3 cm of normal kidney is procured for Grossly, the tumor is not invading out of capsule. Gross photos taken.  Procurement was performed by In Surgical Pathology, the specimen is further inked and seriallv sectioned. The vascular and ureteral margins are identified and submitted in white cassette #2A for permanent processing. The tumor measures approximately 11 cm x 12 cm x 10.5 cm. After fixation, the specimen weighs 722 grams. Sections of the tumor and the black inked specimen. margin are submitted 2B, 2C, 2D, and 2E. Representative section of tumor is submitted in 2F. Representative section of tumor and inked specimen margin are submitted in 2G, 2H.. Two representative sections of tumor are submitted in 2l, 2J. Two representative sections of uninvolved kidney are submitted in 2K, 2L.. Patient Identification. Page 2 of 3
+
+--- Page 3 ---
+Two representative sections of the adrenal are submitted in 2M, 2N. Representative sections of tumor and capsule are submitted in #2O, 2P, 2Q. Gross description dictated by. Additional gross description dictated by. No consultants Patient Identification Page 3 of 3
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diff --git a/output/text/912de0d0-3375-4f0d-a4e6-c5dbf2f0210e.txt b/output/text/912de0d0-3375-4f0d-a4e6-c5dbf2f0210e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4b27ccfdc90b2c8e88b446dfda547bf910a22a8c
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+--- Page 1 ---
+1cD-0-3 mfilt^atiNg duct,NOS Carcin oma. 12/8/10 85 0u|3 c50.9 S.te Cod: brsot, NOs. TSS UUID:EF28484E-82C7-4988-A6E0-DDDA555652EA TCGA-E2-A156-01A-PR Redacted SPECIMENS: A. SENTINEL LYMPH NODE #1, LEFT AXILLA B. SENTINEL LYMPH NODE #2, LEFT AXILLA C. NON-SENTINEL LYMPH NODE LEFT AXILLA D. WIDE EXCISION LEFT BREAST MASS  E. ADDITIONAL NEW MARGIN SUPERIOR LATERAL F. SKIN AT ANTERIOR MARGIN SPECIMEN(S): A. SENTINEL LYMPH NODE #1, LEFT AXILLA B. SENTINEL LYMPH NODE #2, LEFT AXILLA C. NON-SENTINEL LYMPH NODE LEFT AXILLA D. WIDE EXCISION LEFT BREAST MASS E. ADDITIONAL NEW MARGIN SUPERIOR LATERAL F. SKIN AT ANTERIOR MARGIN INTRAOPERATIVE CONSULTATION DIAGNOSIS: TPA, Sentinel lymph node #1, left axilla, excision: Negative for carcinoma TPB, Sentinel lymph node #2, left axilla, excision: Negative for carcinoma. Part D, Left breast, excisional biopsy, gross examination: Tumor approximately 0.3-cm from the posterior margin Diagnoses called at. \ and B) and . (D) by Dr. GROSS DESCRIPTION: A. SENTINEL LYMPH NODE #1, LEFT AXILLA Received fresh labeled with the patient's identification and designated "sentinel lymph node number one left axilla" is a fragment of red-tan possible lymphoid tissue measuring 1 x 0.5 x 0.3-cm. Touch preparation is performed. The entire specimen is submitted, A1. B. SENTineL LympH nODE #2, LEfT AXILLA Received fresh labeled with the patient identification and designated "sentinel lymph node number two left axilla" is fragment of red-tan possible lymphoid tissue measuring 1.3 x 0.5 x 0.2 cm. Touch preparation is performed. The entire specimen is submitted, B1. C. NON-SENTINEL LYMPH NODE LEFT AXILLA Received in formalin labeled with the patient's identification and designated "Non-sentinel lymph node left axilla" is a fragment of adipose tissue, 2.5 x 2.4 x 0.5 cm, consisting of one possible lymph node measuring 1 x 0.5 x 0.4 cm. The lymph node is submitted, C1. D. WIDE EXCISION LEFT BREAST MASS Received fresh labeled with the patient's identification and designated "wide excision left breast" is a previously inked, oriented, 89-g, 9 x 8.4 x 2.5 cm lumpectomy specimen. The single clip designates superior, double-lateral, triple-anterior. ink code: Anterior-yellow, posterior-black, superior-blue, inferior-orange, medial- green, lateral-red. The specimen is serially sectioned from medial to lateral into 7 slices revealing an irregular friable soft tan mass, 3 x 2.4 x 0.9 cm, located 0.3-cm from the nearest posterior margin (Slices 3-5). A previous hemorrhagic biopsy cavity is identified 0.6-cm from the mass (lateral), measuring 1.4 x 0.8 x 0.7 cm. A portion of the specimen is submitted for tissue procurement. Representatively submitted: D1-D2: Representative perpendicular sections, medial margin D3: Slice 2, posterior D4: Slice 2, superior D5-D11: Slice 3, entirely submitted, D8 and D10 demonstrating tumor D12-D15: Slice 4, posterior/superior/anterior/superior, tumor D16-D19: Slice 5, D16-D18 demonstrating biopsy cavity  D20-D21: Slice 6, superior, remainder of biopsy cavity D22-D25: Perpendicular sections lateral margin, entirely submitted E. ADDITIONAL NEW MARGIN SUPERIOR LATERAL Received in formalin labeled with the patient's identification and designated "additional new margin superior lateral" is a previously inked, 6-g, 5.2 x 3 x 0.8 cm fragment of fibroadipose tissue. Ink code: Superior-blue, lateral-red. Sectioning shows no obvious gross abnormalities. The entire specimen is submitted, E1-E2 (superior), E3-E4. (lateral). F. SKIN AT ANTERIOR MARGIN Received in formalin labeled with the patient's identification and designated "skin at anterior margin" is a slender. fragment of unoriented light beige skin measuring 2.1 x 0.6 x 0.2 cm. the entire specimen is submitted, F1. DIAGNOSIS: A. LYMPH NODE, SENTINEL #1, left AXILLA, EXCISION:I - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1).
+
+--- Page 2 ---
+B. LYMPH NODE, SENTINEL #2, left AXILLA, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1). C. LYMPH NODE, non-SENTINEL, left AXILLA, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1). D. BREAST, LEFT, WIDE LOCAL EXCISION - INVASIVE DUCTAL CARCINOMA, SBR GRADE 2, MEASURING 1.8-CM  - INTERMEDIATE NUCLEAR GRADE, DUCTAL CARCINOMA IN SITU, SOLID AND CRIBRIFORM TYPE WITH CENTRAL NECROSIS AND MICROCALCIFICATIONS WITH A COMPONENT OF INTRACYSTIC PAPILLARY CARCINOMA - SURGICAL RESECTION MARGINS NEGATIVE FOR INVASIVE TUMOR - MICROSCOPIC FOCUS OF LOW GRADE DUCTAL CARCINOMA IN SITU AT INFERIOR SURGICAL RESECTION MARGIN - BIOPSY SITE CHANGES WITH FIBROSIS AND GRANULATION TISSUE - SEE SYNOPTIC REPORT AND SEE NOTE. e. breast, left, additional superior lateral margin, excision: - fibroadipose tissue, NO TUMOR SEEN f. skin, anterior margin, excision: - SKIN tissue, NO TUMOR SEEN. NOTE: Ductal carcinoma is identified in 5 consecutive slices. The tumor is composed of 3 components, invasive, in situ and intracystic. The gross measurement of the tumor is a 3-cm. The largest confluent invasive tumor measures 1.8-cm. A microscopic focus of low-grade DCiS is identified at the inferior surgical resection margin.. SYNOPTIC REPORT - BREAST Specimen Type: Excision Needle Localization: No Laterality:  Left Invasive Tumor: Present Multifocality:  No  WHO CLASSIFICATION  Invasive ductal carcinoma, NOS 8500/3 Tumor size: 1.8cm Tumor Site: Not specified Margins: Negative Distance from closest margin: 0.3cm deep Tubular Score: 2 Nuclear Grade: 2 Mitotic Score: 2 Modified Scarff Bloom Richardson Grade: Necrosis: Absent  Vascular/Lymphatic Invasion: None identified Lobular neoplasia: None Lymph nodes: Sentinel lymph node only Lymph node status Negative 0/3 DCIS present Margins involved by DCIS: inferior DCIS Quantity:Estimate 20% DCIS Type: Solid Cribriform intracystic DCIS Location:Associated with invasive tumor Nuclear grade: Intermediate Necrosis: Present Location of CA++: DCIS ER/PR/HER2 Resuits ER: Positive PR: Positive
+
+--- Page 3 ---
+HER2: Negative by IHC Performed on Case:. Pathological staging (pTN): pT 1c N 0 CLINICAL HISTORY: None given PRE-OPERATIVE DIAGNOSIS: Left breast mass ADDENDUM: ONCOTYPE DX BREAST CANCER ASSAY RESULTS: Recurrence Score: 0  0 in the clinical validation study had an average CLINICAL EXPERIENCE: Patients with a recurrence score of: rate of Distant Recurrence at 10 years of 3% ER Score: 11.8 Positive PR Score: 10  Positive Her2 Score: 9.8 Negative Interpretation:  Negative < 6.5 Positive >= 6.5 ER PR Negative < 5.5 Positive >= 5.5 Her2 Negative <10.7 Positive >=11.5 Equivocal = 10.7 - 11.4 See separate : I report for further information. Test performed at: Gross Dictation:   Microscopic/Diagnostic Dictation: Final Review: Pathologist. ' Final: Pathologist, Addendum: Pathologist, Addendum Final: Pathologist, ual/Syr ase Is (circle
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diff --git a/output/text/913d0738-f9ea-4613-9842-a3f31d40a366.txt b/output/text/913d0738-f9ea-4613-9842-a3f31d40a366.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ee9f20b0daafd80d8db6e6157f08e432b77ffa75
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Clinigal Diagnosis & History:. UUID:967287FE-7751-4A90-9465-0A1AD007061D0 Left breast carcinoma. TCGA-AO-A03M-01A-PR Redacted Specimens Submitted: 1: SP: Left breast DIAGNOSIS: 1) BREAST, LEFT; TOTAL MASTECTOMY: - INVASIVE DUCTAL CARCINOMA, POORLY DIFFERENTIATED, HISTOLOGIC GRADE III/III, NUCLEAR GRADE III/III, MEASURING 1.7 - THE TUMOR IS LOCATED IN THE UPPER OUTER QUADRANT. CM MICROSCOPICALLY. -NO IN SITU COMPONENT IS IDENTIFIED LYMPHOVASCULAR INVASION IS PRESENT. - NO IHVOLVEMENT OF THE NIPPLE BY CARCINOMA. - NO SKIN INVOLVEMENT BY CARCINOMA IS IDENTIFIED. - THE SURGICAL MARGIN IS FREE OF TUMOR.S  THE NON-NEOPLASTIC BREAST TISSUE SHOWS BIOPSY SITE CHANGES AND FIBROCYSTIC CHANGES. RESULTS OF THE IMMUNOHISTOCHEMICAL STAINS (ER, PR, HER-2/NEU) WILL BE REPORTED IN AN ADDENDUM. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. *** Report Electronically Signed Out *** Special Studies: Result Special Stain. 1cs-0-3 Comment ER-C PR-C carciionu, infiltratrg cluct, nivs HER2-C 8.5oi/ 3 NEG CONT IMM RECUT NEG-HER2 Site: busst, nos c5o.7 10/2J ** Continued on next page **
+
+--- Page 2 ---
+Gros s.Description: m.d. 1) The specimen is received fresh, labeled "Left breast ,stitch marks. axillary tail" and consists of a breast measuring 19 x 14 x 5 cm with overlying skin ellipse measuring 9 x 2.5 cm. Situated centrally on the skin surface is an everted nipple measuring 1.5 x 1.5 cm and areola measuring 3 x 2.5 cm. A suture demarcates the axiliary aspect. The posterior surface of. the breast is inked black and the specimen is serially sectioned to reveal. an ill-defined white tan area measuring 5 x 4 x 3 cm, located 0.4 from the deep margin in the upper outer quadrant. fibrous area measuring 6 x 5 x 4 cm The remaining breast tissue shows There is an adjacent ill-defined lobulated fibrofatty tissue. The axillary aspect is dissected to reveal no. grossly identifiable lymph nodes. specimen are submitted. Representative sections of the mastectomy. Summary of sections: N - nipple NB - nipple base S - skin D -  deep margin UIQ - upper inner quadrant LIQ  - lower inner quadrant UOQ  - upper outer quadrant LOQ  - lower outer quadrant hemorrhagic area ill-defined area  suspicious for tumor Summary of Sections: Part 1:  SP: Left breast Block Sect. Site PCs D 2 H 1 2 LIQ 2 LOQ 1 2 1 1 NB 1 s 1 1 T 22 UIQ 5 2 2 UOQ Procedures/Addenda: Addendum ** Continued on next page
+
+--- Page 3 ---
+Date Ordered: Page 3 of 3 Status: Date Complete: By: ate Reported: Addendum Diagnosis ADDENDUM BREAST, LEFT; TOTAL MASTECTOMY: THE INVASIVE CARCINOMA SHOWS THE FOLLOWING IMMUNOPHENOTYPE: ER:  POSITIVE (7O% NUCLEAR STAINING WITH MODERATE INTENSITY) - PR:  POSITIVE (60% NUCLEAR STAINING WITH MODERATE TO STRONG INTENSITY) - HER-2/NEU (HERCEPTEST) : STAINING INTENSITY OF 2+. CONTROLS ARE SATISFACTORY. MD ** End of Report
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index 0000000000000000000000000000000000000000..41405d078843463e6527a5fa7796e6ad1115983d
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+TCGA-AZ-4684 FINAL DIAGNOSIS: PARTS 1 AND 2: RECTOSIGmOID COLON, ANASTOmOTIC RINGS, LAPAROSCOPIC COLECTOMY AND ANASTOmOSIS -- A. FungatIng, nOn-CircumferenTial, invasIve, mOderateLy tO pOOrly-DiffErentiated COLORECTAL ADENOCARCINOMA, 5.5 CM IN GREATEST DIAMETER. CARCINOMA STRADDLES THE RECTOSIGMOID JUNCTION WITH INVASION THROUGH MUSCULARIS PROPRIA AND FOCAL EXTeNSION iNto pericolorectal Adipose tissue. B. PRESUMED ANGIOLYMPHATIC INVASION (See diagnosis D). C. AlL. SUrgiCaL RESEctIOn mArGiNS ARE BENIGN. CArcINOmA IS 0.5 Cm FROM The CLOSEST (circumferential) RESECTION MARGIN (Slide 1I). D. METASTATIC COLORECTAL ADENOCARCINOMA IS PRESENT IN TEN OF TWELVE (10/12) REGIONAL Lymph NODeS. THe LArgeSt MetAstaTiC fOCUs mEaSureS 1 CM In GREATeSt DiAmeTeR (Slide 1U). NO EXtrACApsuLAR EXtenSiOn iS IDenTIFIeD (see comment). E. TWO SMALL HYPERPLASTIC POLYPS (Slides 1O and 1P). F. NON-NEOPLASTIC COLORECTAL MUCOSA WITH NO SIGNIFICANT HISTOPATHOLOGIC ABNORMALITY. G. TNM PATHOLOGIC STAGE: pT3, N2, Mx (see Synoptic). Part 3: Appendix, Appendectomy --  APPENDIX WITHOUT HISTOPATHOLOGIC ABNORMALITY. A. B.  nO eVIDeNCE Of MALIGNanCy. Part 4: RIght dome Of Liver, Liver biopsy --  METASTATIC COLONIC ADENOCARCinOmA IN LIVER (Slides 4A and 4B). CASE SYNOPSIS: SyNOpTIC DATA - PRImARy COLON, RECtAL, ApPEnDIX tumORS SPECIMEN TYPE:  Rectal/rectosigmoid colon (low anterior resection) SPECIMEN LENGTH: 23.5 cm TUMOR SITE:  Rectosigmoid TUMOR CONFIGURATION: Exophytic (polypoid) TUMOR SIZE: Greatest dimension: 5.5 cm Additional dimensions: 3.5 cm. INTACTNESS OF MESORECTUM: Complete HISTOLOGIC TYPE: Adenocarcinoma HISTOLOGIC GRADE: Other: Moderate to poorly differentiated PATHOLOGIC STAGING (pTNM): pT3a/b pN2 Number of nodes examined: 12. Number of nodes involved: 10. pM1 Site(s): Liver MARGINS: Proximal margin uninvolved by invasive carcinoma. Distal margin uninvolved by invasive carcinoma Circumferential (radial) margin uninvolved by invasive carcinoma  Mesenteric margin uninvolved by invasive carcinoma. ANGIOLYMPHATIC INVASION: Present PERINEURAL INVASION: Absent TUMOR BORDER CONFIGURATION: Infiltrating TUMORAL LYMPHOCYTIC RESPONSE: Mild to moderate ADDITIONAL PATHOLOGIC FINDINGS: Other polyps (type[s]):Two hyperplastic polyps
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diff --git a/output/text/91d471da-486a-4a9f-9624-aad0e2847f18.txt b/output/text/91d471da-486a-4a9f-9624-aad0e2847f18.txt
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+1ed- 0- 3 Carcmomu medullary.N0s 8510f3 Path 12/3110 hw CQcF Sif: bUast,nos c50.9 Final diagnosis Breast, left, simple mastectomy: Medullary carcinoma forming a 4.5 x 2.0 x 2.0 cm well circumscribed mass (AJCC p T2) in the upper outer quadrant associated with prior biopsy site. The surgical margins are widely negative. Seen with Dr. Lymph nodes, left axillary sentinel, excision: Multiple (5) left axillary sentinel lymph nodes are negative for tumor. Blue dye is not identified in any of the five left axillary sentinel lymph nodes. (AJCC pN0(i-)). Immunohistochemical cytokeratin stain was performed on the paraffin embedded sentinel lymph node tissue and confirms the H&E impression. UUID:F5CAE962-5347-46FA-86EE-169121BE0547 TCGA-AR-A1AI-01A-PR Redacted
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diff --git a/output/text/91e13df1-9161-4054-974c-ea6de1c83942.txt b/output/text/91e13df1-9161-4054-974c-ea6de1c83942.txt
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+UUID:32288888-100F-4838-9771-EAEE5A38817A 1cs-0-3 TCGA-AR-A0U0-01A-PR Redacted Carci oma n fiImaHng cluct nos 85o0f3 S.ts: srest, Nos c5o.9 Breast, left breast, simple mastectomy: Infiltrating ductal carcinoma, Nottingham grade III (of III). forming a 2.3 x 1.8 x 1.5 cm mass (AJCC pT2) situated in the lower inner quadrant at 2.0 cm from the closest (inferior) margin. Vascular invasion is identified. The rest of the breast shows proliferative fibrocystic change with ductal hyperplasia of the usual type, apocrine metaplasia, and microcalcifications.. Duct ectasia is also present. The nipple is unremarkable. Surgical margins are negative.. Lymph nodes, left axillary sentinel, excision: Multiple (2) left axillary sentinel lymph nodes each of them showing one cluster of cells visible on cytokeratin immunohistochemistry stain only, but not on H&E (size of micrometastasis is less than 0.2 mm) (blue dye present in both left axillary sentinel lymph nodes). Lymph nodes, left axillary, excision: Multiple (2) left axillary lymph nodes are negative for tumor. Estrogen: Negative, 0% nuclear staining Progesterone: Negative, 0% nuclear staining ER (Estrogen Receptor) test was developed and its performance characteristics determined by - It has not been cleared or approved by the U.S. Food and Drug Administration.. Seen in consultation with Drs.  and
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+Page l of2 UUID:791E29AD-22A6-402E-978C-69407C68748F TCGA-G3-ASSM-01A-PR Redacted Note: If you do not see "END OF PRINTeD REPORT" at the bottom of th  the report you Do not have The Entire Report. Please try prin CONFIDENTIAL SURGICAL PATHOLOGy REPORt Time Collected Time Reported Order Number Ordering Provider Status Final Relevant Information Location IcD-o-3 OLcursoaraomc..  hepatscelsusar NOS Copied To 8/70/3 Report Patient Name Demographics Site: sLuuer, heeolis, CQQ.D Date of Birth: (for verification purposes) Sex: M tO y1z/13 Surgical pathoLOgy REpOrt *Surgical Pathology Report* Accession Number Collected Date/Time Received Date/Time Pathologist Specimen Description A. Gallbladder B. Hcc tumor left lobe C. Deep margin D. Final margin liver lobe left. Clinical Information Infectious patient:Yes - Hep + Cirrhosis, hepatocellular carcinoma? Diagnosis A. Gallbladder, Cholecystectomy:. Gallbladder with no pathologic abnormality B. Liver, (Left Lobe), Wedge Resection:. Hepatocellular carcinoma, Grade IIl/IV. The tumor measures 2.7 cm in maximal dimension Carcinoma is present at the cauterized/inked parenchymal margin in this specimen (see comment) Yocal small vessel invasion is seen within the tumor itself No perineural invasion identified Cirrhosis of the surrounding liver parenchyma
+
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+Page 2 of 2 C. Liver, (Deep Margin), Excision: - Negative for hepatocellular carcinoma.. D. Liver, (Final Margin), Excision: - Negative for hepatocellular carcinoma.. Electronically signed by: Veri fior. Gross Description Received are specimen containers A tn n sll roanisitions and specimen containers are. labelled with the patient's name, The cassettes and Ap identifiers are labelled with the Surgical Number. A. The specimen is designated "Gallbladder". The specimen is received fresh and is. subsequently placed into formalin and consists of a gallbladder that measures 10.0 x 4.0 x 4.0 cm.  Opening the gallbladder reveals approxinately 10 ml of dark green bile. The serosa of the galibladder appears unremarkable as does the mucosal surface.  There are no stones present. A section of mucosa is submitted in cassette Al. B. The specimen is designated "Hcc tumor left lobe". The specimen is received fresh and is subsequently placed into formalin and consists of a piece of liver that weighs 43.8 g and neasures 4.0 x 4.5 x 4.0 cm.  There is a solitary firm, tan nodule present at the inked margin of the specimen and this nodule measures 2.7 x 2.7 x 2.5 cm. The surrounding liver parenchyma is cirrhotic.  Random sections of the tumor are submitted in cassettes B1 toB5.  B6 contains uninvolved cirrhotic liver parenchyma. C. The specimen is designated "Deep margin'. The specimen consists of a small fragment of firm brown tissue that measures 1.0 x 0.8 x 0.2 cm. It is submitted in toto in cassette C1. D. The specimen is designated "Final margin liver lobe left".. The specimen consists of a firm brown friable tissue that measures i.1 x 1.0 x 0.2 cm. This is submitted in toto in cassette Dl. Pathologist Comment Although tumor is present at the inked margin in specimen "b", the final resection margins (specimens "c" and "p") are free of tumor. Accession Number Encounter Number Patient Location - End Of printed repOrt -- mor Ste
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+UUID:6EA3F877-3DD4-43C8-8C39-CA8755EBC50C0 TCGA-OR-ASK5-01A-PR 'Redacted PREVIOUS NIAGNNSIS INQUIRY PAGE #: 2 SEX: F BIRTHDATE: PAT TYPE: ADM DATE: tCD o-3 Carcinoma, Adreual corticol 8370/3 Site; C Adrenal Gland,Cortex Q 74.D AtS1|80/3 OPER DATE: PROCEDURE: SPHS Patient with left adrenal mass. PROCEDURE: SPGD 1. "l adrenal mass" Received fresh for frozen section is a fully-encapsulated, 447 gram, excision specimen (up to 14.5 cm x up to 9.5 cm x up to 6 cm). Inked green on its entire exterior capsule and bivalved to reveal an interior,. Sampled for frozen section analysis and extensively for tissue procurement. Extensively sectioned to reveal scant extratumoral adipose, no attached lymph. nodes, and no identitiable uninvolved adrenal tissue. Gross estimation of necrotic tumor mass approximately 30%.. 1A. Frozen section control.. 1B-c. large central sections of lesion. 1D-K. Additional sections showing full range of gross morphology of the lesion and sampling margins from which it is grossly free.  greater than one. section per cm of tumor).. 2. "Left periaortic lymph node packet" Received in formalin in a small container is a lymphadenectomy specimen (4 x 3 x 2 cm). Serially sectioned to reveal multiple small lymph node candidates.. 2A-D.1 candidates, smail amount of adipose tissue) 3. "Left suprarenal periaortic lymph nodes" Received in formalin in a small container is a lymphadenectomy specimen (2 x 2 x 0.6 cm). Dissected, the. specimen appears to consist predominantly of vascular tissue. Subnitted ontirely in cassette 3A.
+
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+PREVIOUS DIAGNOSIS INQUIRYS PAGE #: SEX: F ADM DATE: BIRTHDATE: OPER DATE: FROZEN SECTION REPORT 1. Positive for carcinoma. Frozen section diagnosis is confirmed. PROCEDURE: SPMI ADRENOCORTICAL CARCINOMA Tumor Size: 14.5 x 9.5 x 6 cm Tumor Weight: 447 grams Capsular Invasion: Yes Vascular Invasion: Yes Surgical Margins: Negative but close Necrosis: Yes Mitotic Rate: 31 mitoses / 50 high power fields High Grade: Lymph nodes status: Negative (0/20). Extra-adrenal extension: Yes, focal Stage: III (extra-adrenat extension) I mmunohistochemistry Results:. NA PROCEDURE: SPDX 1. Lett adrenal gland, resection: Adrenocortical carcinoma, high-grade by nitotic rate, margins negative but close. See Template.
+
+--- Page 3 ---
+ PREVIOUS DiAGNOSIS INQUIRYE PAGE #: SEX: F BIRTHDATE: ADM DATE: OPER DATE: 2. Lymph node, left periaortic, excision: Twenty lymph nodes negative for carcinoma (0/20). 3. Soft tissue, left suprarenal, excision: Ganglion and fibrovascular tissue, negative tor carcinoma.. ., the signing staft pathologist, have. personaily examined and interpreted the slides from this case. ** END OF PREVIOUS DIAGNOSIS INQUIRY ** 122
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+Cavinrna, nfiI+nst^nj duct Nos 85of3 TSS: CQCF s:t: brust,n1s c50.9 12]24f!0 lu TSS: SPECIMENS: A. SENTINEL LYMPH NODE #1 LEFT AXILLA B. SENTINEL LYMPH NODE #2 LEFT AXILLA UUID:539FF792-534D-401D-87A6-B387C2BC2EFC C. SENTINEL LYMPH NODE #3 LEFT AXILLA TCGA-E2-A1B6-01A-PR Redacted D. SENTINEL LYMPH NODE #4 LEFT AXILLA E. LEfT BREAST F. ADDITIONAL SKIN UPPER SUPERIOR FLAP G. RIGHT BREAST SPECIMEN(S): A. SENTINEL LYMPH NODE #1 LEFT AXILLA B. SENTINEL LYMPH NODE #2 LEFT AXILLA C. SENTINEL LYMPH NODE #3 LEFT AXILLA D. SENTINEL LYMPH NODE #4 LEFT AXILLA E. LEFT BREAST F. ADDITIONAL SKIN UPPER SUPERIOR FLAP G. RIGHT BREAST INTRAOPERATIVE CONSULTATION DIAGNOSIS TPA-TPD: sentinel nodes #1-#4, left axilla: All negative for tumor cells on touch prep, called to Dr. at by Dr. GROSS DESCRIPTION: A. SENTINEL LYMPH NODE #1 LEFT AXILLA Received fresh labeled with the patient's identification of a fragment of beige tan soft tissue measuring 1. x 1 x 0.3 cm. Touch preparations are performed. The entire specimen is submitted in cassette A1. B. SENTINEL LYMPH NODE #2 LEFT AXILLA Received fresh labeled with the patient's identification of a fragment of beige tan soft tissue measuring 1. x 1 x 0.3 cm. Touch preparations are performed. The entire specimen is submitted in cassette B1 and B2. C. SENTINEL LYMPH NODE # 3 LEFT AXILLA Received fresh labeled with the patient's identification are two possible lymph nodes measuring O.5 x 0.5 x 0.2 cm each. Both lymph nodes are entirely submitted separately in C1 and C2.. D. SENTINEL LYMPH NODE # 4 LEFT AXiLLA Received fresh labeled with the patient's identification of a fragment of beige tan soft tissue measuring. 0.7 x 0.7 x 0.5 cm. Touch preparations are performed. The entire specimen is submitted in cassette D1. E. LEFT BREAST Received fresh labeled with the patient's identification and designated *Part E., left breast" is an orientated 399g, 18 x 17 x 3 cm mastectomy specimen with a 5.2 x 3.3 cm skin ellipse, and 1.2cm everted nipple. Ink code: Anterior/superior-blue, anterior/inferior-orange, posterior-black. Specimen is serially sectioned into 9 slices from medial to lateral with nipple in slice 3 revealing a 3.5 x 3.1 x 2 cm firm beige spiculated mass at the 12 o'clock position (slices 5-7) closest to the anterior margin at 0.9cm. and located 2.2cm from the deep margin. Tissue is procured. Representatively submitted:. E1: Perpendicular sections, nipple E2: Bisected nipple base E3: Sections of skin E4: Tumor, slice 5 E5-E8: Tumor, slice 6 E9: Overlying deep margin, slice 6. E10: Tumor, slice 7 E11: Tumor and closest anterior margin, slice 7 E12: Additional tumor, slice 7. E13: Upper outer quadrant. E14: Lower outer quadrant E15: Upper inner quadrant E16: Lower inner quadrant F. ADDITIONAL SKIN UPPER SUPERIOR FLAP Received in formalin in a container labeled with the patient's identification is a brown tan crescent shaped excision of skin measuring 6.1 x 2.5 x 0.3 cm. A suture designates superior. The specimen is.
+
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+Tss: inked as follows: Superior-blue, inferior-orange, deep-black. The surface of the skin demonstrates no obvious gross abnormality. The specimen is serially sectioned from medial to lateral and submitted entirely for microscopic evaluation. Cassettes are submitted as follows: F1: Medial tip F2-F6: Serial sections F7: Lateral tip G. RIGHT BREAST Received fresh labeled with the patient's identification and *Right Breast-Stitch marks axillary tail is an. oriented 339g, 23 x 14 x 3cm simple mastectomy with 5 x 3cm tan pink skin ellipse, and a 1.3cm centrally located, raised nipple. Ink Code: Anterior-Superior: Blue, Anterior-Inferior: Orange, Posterior: Black. The specimen is serialty sectioned from lateral to mediai into 15 slices. The nipple is located in. slice 12. The cut surfaces reveal a blue dome cyst 0.8 x 0.4cm in the LC of slice 12, more than 1cm. from the closest deep margin. No lesions are grossly identified. Representative sections are submitted. as follows: G1: nipple slice 12 G2: skin slice 12 G3: UOQ slice 8 G4: UOQ slice 9 G5: LOQ slice 7 G6: LOQ slice 10 G7: blue dome cyst LC slice 12 G8: LC with inferior margin slice 12 G9: UC slice 12 G10: UIQ slice 13 G11: UIQ slice 14 G12: LIQ slice 13 G13: LIQ slice 14 DIAGNOSIS: A. SENTINEL LYMPH NODE #1, LEFT AXILLA, BIOPSY: - ONE LYMPH NODE, NO TUMOR SEEN (0/1). B. SENTINEL LYMPH NODE #2, LEFT AXILLA, BIOPSY: - ONE LYMPH NODE, NO TUMOR SEEN (0/1). C. SENTINEL LYMPH NODE #3, LEFT AXILLA, BIOPSY: - TWO LYMPH NODES, NO TUMOR SEEN (O/2). D. SENTINEL LyMPH NODE #4, LEFT AXILLA, BIOPSY: - ONE LYMPH NODE, NO TUMOR SEEN (0/1). E. breaSt, LEft, MAStecTOmy: - INVASIVE DUCTAL CARCINOMA, POORLY DIFFERENTIATED (SBR GRADE 3) (SEE NOTE) - TUMOR MEASURES 3.5 CM IN GREATEST DIMENSION. - MARGINS, FREE OF TUMOR. - DUCTAL CARCINOMA IN SITU (DCIS), SOLID TYPE, NUCLEAR GRADE 3, WITH NECROSIS, MICROCALCIFICATIONS AND ASSOCIATED LYMPHOID INFILTRATE.E - SKIN AND NIPPLE, NO TUMOR SEEN. NOTE: Biomarkers and lymphvascular invasion status will be reported in an addendum. F. SKIN, UPPER SUPERIOR FLAP, EXCISION: - BASAL CELL CARCINOMA, SUPERFICIAL TYPE (SEE NOTE). - MARGINS, FREE OF TUMOR. NOTE: The basal cell carcinoma is focally 2 mm from the superior margin. G. bREAST, RIgHT, PROPHyLACTIC MASTECTOMY: - SMALL FIBROADENOMA, PSEUDOLACTATIONAL CHANGE, APOCRINE
+
+--- Page 3 ---
+TSS: : METAPLASIA, STROMAL FIBROSIS, AND MICROCALCIFICATIONS. - BENIGN SKIN AND NIPPLE. SYNOPTIC REPORT - BREAST Specimen Type: Mastectomy Needle Localization:  No Laterality: Left Invasive Tumor: Present Multifocality: No WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Tumor size:3.5cm- Tumor Site: 12:00 Margins: Negative Distance from closest margin:  0.5cm anterior superior Tubular Score: 3 Nuclear Grade: 3 Mitotic Score: 3 Modified Scarff Bloom Richardson Grade: 3 Necrosis: Present Lobular neoplasia: None Lymph nodes: Sentinel lymph node only Lymph node status: Negative 0/5 DCIS present Margins uninvolved by DClS : 0.5cm from anterior superior margin DCIS Quantity: Estimate 40% DCIS Type: Solid DCIS Location: Associated with invasive tumor Nuclear grade: High Necrosis: Present Location of CA++: DCIS Pathological staging (pTN): pT 2 N 0 CLINICAL HISTORY:  None given PRE-OPERATIVE DIAGNOSIS:  None given ADDENDUM: NOTE: A CD31 stain was performed on block E6 and is negative, showing no evidence of. Iymphvascular invasion. SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimen:  Surgical Excision Block Number: E10 ER: Negative Allred Score: 0 = Proportion Score 0 + Intensity Score 0 PR: Negative Allred Score: 0 = Proportion Score 0 + Intensity Score 0 COMMENT: The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the. proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring range from O to 8. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score. of less than or equal to 2.
+
+--- Page 4 ---
+Tss: METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Immunohistochemistry was performed usina the mouse anti-human ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) provided by Dakc ollowing the manufacturer s instructions. This assay was not modified. Interpretation of the ER/PR immunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal review of staining performance. SYNOPTIC REPORT - BREAST HER-2 RESULTS Specimen: Surgical Excision Block Number: E10 Interpretation: EQUIVOCAL Intensity: 2+ % Tumor Staining. 15% Fish Ordered: Yes , on Date METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Her2 analysis was performed using the FDA approved Dako HercepTest (TM) test kit. C using rabbit anti-human HER2. This assay was not modified. External kit-slides  provided by the manufacturer (cell lines with high, low and negative HER2 protein expression) and in- house known HER2 amplified control tissue were evaluated along with the test tissue. Adequate, well preserved, clear-cut invasive carcinoma was identified for HER2 evaluation. Interpretation of the HER2 immunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal review of staining performance. This assay has been validated according to the sint recommendations and guidelines from ASCO and CAP and from the NCCN HER2 testing in Breast Cancer Task Force. The Pathology Department takes full responsibility for this test's performance.. PathVysion HER-2 DNA Probe Kit Case No Analytical Interpretation of Results: HER-2 NOT AMPLIFIED Clinical Interpretation of results Amplification of the HER-2 gene was evaluated with interphase fluorescence in-situ hybridization (FISH) on formalin-fixed paraffin embedded tissue sections using a chromosome 17 centromeric probe and a HER-2 probe that spans the entire HER-2 gene in the ' by Dr. A majority of tumors cells displayed 2 chromosome 17 signals and 2 HER-2 signals, with a HER-2/CEP 17 Ratio </=2.0, consistent with no amplification of the HER2/neu gene. Block usedE10 Source of case: Tissue fixation formalin-fixed tissue Outside Case No:NA Tissue source breast Results interpreted: yes HER2/CEP17 ratio: 1.03 This ratio is derived by dividing the total number of LSI HER-2/neu signals by the total number of CEP17 signals in at least 20 interphase nuciei with nonoverlapping nuclei in the neoplastic mammary epithelial cells. Ceils with no signals or with signals of only one color are disregarded. Method of ratio enumeration: manual count. Limitations The Vysis PathVysion Kit is not intended for use to screen for or diagnose breast cancer. It is intended to be used as an adjunct to other prognostic factors currently used to predict disease-free and overall survival in stage ll, node-positive breast cancer patients. In making decisions regarding adjuvant CAF treatment, all other available clinical information should also be taken into. consideration, such as tumor size, number of involved lymph nodes, and steroid receptor status. No treatment decision for stage ii, node-positive breast cancer patients should be based on HER- 2/neu gene amplification status alone. Overview of this test FDA APPROVED REAGENT PathVysion HER-2 DNA Probe Kit is FDA approved for selection of  patients for whom Herceptin therapy is being considered. These tests were performed in the
+
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+TSS:  under the direction of Dr. The results of these studies should always be interpreted in the context of the clinical, morphological, and immunophenotypic diagnosis. Gross Dictation: Pathologist, Microscopic/Diagnostic Dictauon: Patnologist, 1 Final Review: Pathologist, Final Review: Pathologist, Final: Pathologist, ^ Addendum: Patholcyist, Addendum Final: Pathoiogist, Addendum: Pathologist, Addendum Final: Patholuyist
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+TCGA-A3-3323 Laboratory  Patien Print Date/Time: Surgical Pathology Histopathological Examination Path#: Collected: Received: Complete Pre-Op Diagnosis : Right Renal Mass Order Physician Specimens Kidney,  Right Frozen Diagnosis Report  GROSS EXAMINATION: The specimen is received in a container labeled with the name of the patient and labeled as kidney, right.  The specimen consists of a kidney and attached perinephric fat which measures en bloc 21 x 14 x 7 cm and weighs 911 g. The ureter and vascular margins of resection are submitted in block 1. Sectioning into the kidney shows an oval golden yellow mass in the midportion of the specimen.. The mass measures 5 x 4.5 x 4.0 cm. The mass is focally adherent to the overlying capsule. A section of the mass, adjacent capsule and inked surgical margin are submitted in block 2. The mass qrossly extends into a calyx in an area measuring 1.5 x 1.4 cm. Sections of the mass are submitted in blocks 3-8. The pelvis and calices are not grossly dilated.. The cortex averages 0.7 cm. A random section of kidney is submitted in block 9. The attached fat is dissected and no lymph nodes or adrenal tissue are identified.. DIAGNOSIS BASED ON GROSS AND MICROSCOPIC EXAMINATION: SPEcIMEN ryPE: Radical nephrectomy. LATERALITY: Right. TUMOR SITE: Middle. FOCALITY: Unifocal. TUMOR SIZE (LARGEST TUMOR IF MULTIPLE) : Greatest dimension: 5.0 cm.. Additional dimensions: 4.5 x 4.0 cm.. MACROSCOPIC EXTENT OF TUMOR: TumOr limited to kidney. HIsToLogic TypE: Clear cell (conventional) renal carcinoma. HISTOLOGIC GRADE (FUHRMAN NUCLEAR GRADE) : Grade I. EXTENT OF INVASION PRIMARY TUMOR (PT): pT1b: Tumor more than 4.0 cm but not more than 7.0 cm in greatest dimension, limited to the kidney. THIS CONFIDENTIAL AND PRIVILEGED DOCUMENT/INFORMATION IS PROTECTED BY FEDERAL AND STATE LAW. UNAUTHORIZED DISCLOSURE,  DISSEMINATION OR DUPLICATION IS PROHIBITED Path Page 1 .of 2 Visit
+
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+REGIONAL LYMPH NODES (PN) : pNX: Cannot be assessed DISTANT METASTASIS (PM): pMX: Cannot be assessed MARgiNs: Margins uninvolved by invasive carcinoma. ADRENAL GLAND: Not present. VENOUS (LARGE VESSEL) INVASION (V): Absent. LYMPHATIC (SMALL VESSEL) INVASION (L) : AbSent. ADDITIONAL PATHOLOGIC FINDINGS: None identified. Intradepartmental consultation obtained. Pathologic stage summary: pT1bNXMXG1  [T-71000 M-83103 189.0 P3-44070] Electronicallv Sianed by CONFIDENTIAL AND PRIVILEGED DOCUMENT/INFORMATION IS PROTECTED BY FEDERAL AND STATE LAW. UNAUTHORIZED DISCLOSURE, DISSEMINATION OR DUPLICATION IS PROHIBITED Page 2 of 2
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diff --git a/output/text/925661ca-b9bc-4dbc-921c-e4bf7ada6530.txt b/output/text/925661ca-b9bc-4dbc-921c-e4bf7ada6530.txt
new file mode 100644
index 0000000000000000000000000000000000000000..426b3cfbc565822d4335b5f5b035abc4b8fe5a49
--- /dev/null
+++ b/output/text/925661ca-b9bc-4dbc-921c-e4bf7ada6530.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:A0378051-D79B-425E-9E0F-120BA6F0EBBA TCgA-2z-A933-01a-pr Redacted Pathology Report Gender: Service: Peceived: Renorte3: Submitctng Phystiara: ID-8-3 Fathologst: Antraop Fatnolcglet: Perrormtng Fhyaciant 8Q4tk3 CLINICU. HISTORY: Sate BKidnyNs`Cby9 NONE QIVEN. FRECPERATIVE DEAGNCSIS RGIT KDNRY MASS A J 4/28/14 SPKCIMEN TYPE(S) A RIGKT KIDREY ANn ADPENAL FANNL DAGNCGIG1 REGHT KELNKY AND RIGHT ADRRNAL GLAND, RADICAL. NEPHEEC CMY Rensl Ca.l. sarcinoma, popillary type :.. (zee Key Patnolcgical Pinainga) Adrenal gland, Iree ot waligraney. Patnologstagepa x MX KEY PATHOLOGICAL FINDINGS Tumor type:: Fanal coil catcinoma, papillary type I Nuciear grades I1 Fattern or gtoutn 501 rumor sizer 17.5 Rensl capauie invssionx Not identitied Invsaion or cerota's Fascta Not applcabie Renal yei invaeon Not identitied Surgical marging: Free or algnancy Ureter zargin: Free or -3lignancy Vascular mirgin: re.oralignancy Angioiyphaticnvasion: Net Inentizied pertceural lrvna:on Not icentlrted Non-ncsplastic kidney Rare gicxarsloscierosis, mild arteris: sclerca:s and tocal interatitial rttrosis Adrenal gland: Free or raligrancy :ymph rsioat Net apptribie M.D. tte stterding patnoloiat, paraonaly revtewed tne.entire pithiogy case and reriered tne rinal lagnoa!a.siectzonicaiy signed ous by. QTHER FELATED CLINICAL LATA NA ARCSSDESCRIRTICN: A. Specimen A.is.received Iresh Iateled*rignt kdney.and adrenai. Tre specien csnslets ot a alss.s-g kidney aurrourded ny'sn Irregular ribresdipoae tlaeue envelope measurtng 23.0 x1s.0 x tl.5 cm. Prtcr to setioning tne specinentne perircpnric rat isirkal. On sectioning.tnereis an ovoid tuzox mass located in tne auperior media: aspect o: the kidney. ine cusor mass weasures 17,s x 1s.o x as.0. . Tne tumor is yariegated tan-yeliow to tan-trown wtth multple aress ot.necroei and hemorrnage. .he tumcr does not lnvade tre calyceal. syetes and dces not snvade the rerai sirua. The turor does not panatrate through tne inner capaule to involve
+
+--- Page 2 ---
+the perinephric tat. The tumor te well demarcsted fron the untnvolved rera Additlonal Lumor noJulea are not presert., Tnexidney parencnyma is tan to tan-red. Tre corticcreuullary junction is well dcnarcatel and neagurea 1.0 cm in thicxnean: Tr.e -edullary cords, calyces ina renst peivis are unremarkable. Attached to the kidney ia' 7-cs lengtn or ureter whicn is unremarkabie. The renal artery. reveals atlg atherosclerotie cnanges, The renal vein Is grossiy unrerarkable. Sactionsng the perihilar ibroadipose tiesue no lymph nodes are laciatec. The aureral.gland 1s attached tothe specixen meaauring 6.0x.3.5x1.0cm.Tne adronai jiand is seriai:y secticned to reveai unremarkable Eut surrace, Leasons or rasses are nos groasiy' sdentir:ed. Reprasentative tresn tissue is autmitten to tre TSRUE Frccurezent Lsboratory. Representativeaectiong are.sutmitted as rol.cws AL: Ureter veln ans srtery aa margin. ot rasection.. Tumor in zelattcn to inkeu perinephric tat marginor A3 rumor in relation to renal parenchyma, -A8 Tumor. A9 unlnvolved rera parenchyma Section st adrensI gland. HIPAAD ALIFIED Case is ci
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diff --git a/output/text/9265bc35-8f91-47f9-9ebc-e596b2e0a448.txt b/output/text/9265bc35-8f91-47f9-9ebc-e596b2e0a448.txt
new file mode 100644
index 0000000000000000000000000000000000000000..174249b69426ee7b3971eb8ca28ab9528f5d1846
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Pathology Report Accession Number: Report Status:  Final Type: Surgical Pathology Specimen Type: Colon Procedure Date: Ordering Provider? CASE: PATIENT: Resident: Pathologis PATHOLOGIC DIAGNOSIS: ADENOcARcINOMA, high grade, moderately differentiated (15 cm in.) greatest dimension). Tumor is located in right colon (cecum), is ulcerative, and has a pushing border. Tumor invades through muscularis propria into serosal surface.. Proximal, distal, and radial resection margins are negative for tumor.. Invasive tumor is 7.5 cm from proximal resection margin, 10 cm from. distal resection margin, and 2 cm from radial resection margin.. Lymphovascular invasion is not identified.. Extramural venous invasion is not identified.. Perineural invasion is identified. Peritumoral lymphoid response (including Crohn's-like infiltrate) is. mild. Residual adenoma is absent. Immunohistochemistry performed at. demonstrates the following staining profile in lesional cells:. Positive - Ck20 (rare) Negative - CK7, CDx2, synaptophysin, chromogranin. Regional lymph nodes (positive:total): 0:35. AJcc Classification (6th edition): T4b N0 MX. NOTE : Immunostains for MLh1 and Pms2 reveal absence of nuclear staining in tumor cells (and intact nuclear. staining in non-neoplastic cells). Immunostains for MSH2 and msh6 reveal intact nuclear staining in.tumor cells. In most tumors with loss of mlhl and Pms2 staining, the defect is caused by. sporadic methylation silencing, and is not associated with a germline mutation. Less commonly, MLh1 and Pms2 ioss is caused by a germline mutation in the MLH1 gene (or rarely in the Pms2 gene), usually in the setting of a family history of colorectal, endometrial, gastric, or other cancers (Hnpcc). Colorectal cancers with mismatch repair deficiency are associated with improved overall patient survival. Clinical correlation is required.. B. SPECIMEN DESIGNATED "LIVER, BIOPSY" (including FSA): Bile duct adenoma. CLINICAL DATA: History: R colon cancer.. Operation: Subtotal colectomy.. Operative Findings: Not provided.. clinical Diagnosis: Adeno CA.. TISSUE SUBMITTED: A. right hemicolectomy B. liver biopsy O.R. CONSULTATION: SPECIMEN LABELED "2. LIVER BIOPSY" (INCLUDING FSA) : Page: 1 of3
+
+--- Page 2 ---
+Pathology Report Bile duct adenoma. Tumor is grossly 7.5 cm from proximal margin and 10 cm from distal margin. SPECIMEN LABELED "1. RIGHT HEMICOLECTOMY": (Gross examination only). OR Consultation by: Resident: The senior physician certifies that he/she personally conducted a gross and/or. microscopic examination of the described specimen(s) and rendered or confirmed the rapid diagnos(es) related thereto. GROSS DESCRIPTION: The specimen is received fresh, in two parts, each labeled with the patient's. name, unit number. Part A, labeled "#1. Right hemicolectomy", consists of a right hemicolectomy, including a portion of terminal ileum (7.0 cm in length), a seqment of right colon and cecum (22.0 cm in length), and an appendix (6.0 cm in length, 0.4 cm. in diameter), and attached pericolic adipose tissue (including a portion of adipose tissue consistent with omentum, measuring 30.0 x 16.0'x 1.2 cm). The proximal stapled resection margin measures 3.0 cm and is inked blue, and the distal stapled resection margin measures 4.0 cm and is inked black. The serosa. is pink and focally firm at the cecum and proximal portion of right colon (1l.0 x 9.0 cm), 7.0 cm from the proximal stapled resection margin and 10.0 cm from the distal stapled resection margin.  The specimen is opened to reveal an exophytic focally ulcerating irregular tan-yellow to pink mass (15.0 x 10.0 x 4.0 cm). The mass involves the adjacent ileocecal valve,. and comes to 7.5 cm from the proximal stapled resection margin, and 10.0 cm from the distal stapled resection margin. Per the surgeon, there is an "adhesed peritoneal folding designated as "true resection margin" (inked black). On cut section, the mass extends into the underlying colonic wall, and into the surrounding pericolic adipose tissue, coming to less than 0.1 cm from the black ink peritonealized margin, as designated per the surgeon, and is 2.0 cm from the closest radial mesenteric margin. Representative sections of the mass are submitted to the GI. stem cell lab for special studies, and additional representative sections of the mass and uninvolved colonic mucosa are submitted to tissue bank for special studies. The remaining mucosa is tan with normal folds, with no additional. discrete masses or lesions identified. Multiple tan-pink rubbery lymph nodes are identified within the surrounding pericolonic adipose tissue, ranging from. 0.2 cm to 1.6 cm in greatest dimension. Gross photos are taken. Representative sections are submitted. Micro Al: Proximal and distal stapled resection margins, radially, 2 frags,. RSS. Micro A2: Appendiceal tips (bisected), and cross sectioned, 4 frags, Rss. Micro A3: closest mesenteric radial margin, en face, 1 frag, Ess.. Micro A4: Appendiceal orifice, 1 frag, Ess. Micro A5: Terminal ileum to ulcerating mass, 1 frag, Rss.. Micro A6: Ileocecal valve, 1 frag, Rss. Micro A7: Ulcerating mass to right colon, 1 frag, Rss. Micro A8-A14: Additional sections of ulcerating mass, with the peritonealized surface, as designated by the surgeon in A9-A13 (inked black), 1 frag each, RSS. Micro A15-A20: Whole proximal lymph nodes,. multi frags each, Micro A21: 1 lymph node, bisected, 2 frags,. Micro A22: 1 lymph node, bisected, 2 frags,. Micro A23: 1 lymph node, bisected, 2 frags, Micro A24: 1 lymph node, bisected, 2 frags,. Part B, labeled "#2. Liver biopsy", consists of a tan-red irregular soft tissue (0.4 x 0.3 x 0.2 cm), which is submitted in toto for frozen section as FsA. Page: 2 of 3
+
+--- Page 3 ---
+Pathology Report Micro B1: FsA remnant, 1 frag, CASE NUMBER: By his/her signature below, the senior physician certifies that he/she. personally conducted a microscopic examination ("gross only" exam if so stated) of the described specimen(s) and rendered or confirmed the diagnosis(es). related thereto. Electronically signed on Page: 3 of 3
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diff --git a/output/text/92a59467-c6fc-41a3-aa5c-c931d091ded1.txt b/output/text/92a59467-c6fc-41a3-aa5c-c931d091ded1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7622f59bd96e3740fe462d74eba3180e1782b20f
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+
+--- Page 1 ---
+UUID:9FCBC793-8E7B-4305-895D-42AED82BE061 TCGA-F9-A433-01A-PR Redacted Gross Description: "Left kidney." A 257 gram, 13.5 x 7.5 x 3.0 cm kidney with a small amount of perinephric fat. The renal artery and vein at the margin are grossly unremarkable. The 5.5 cm long ureter is unremarkable at the margin. 4.5 cm from the margin of resection the lumen is partially. obstructed by a bulging 1.5 x 1.0 cm tumor nodule extending from a 5.5 x 4.5 x 3.0 cm lobulated fleshy gray mass located in the lower pole. This mass is grossly confined within the renal capsule but invades. the renal collecting system. No extension into the scant amount of perinephric fat is identified. There is a well delineation of pale kidney tissue surrounded by viable kidney tissue in the upper pole adjacent to the mass. There are two additional simple cysts, one in the upper pole, one in the lower pole up to 0.9 cm. The surrounding kidney tissue is unremarkable. No enlarged lymph nodes are identified. Microscopic Description: Procedure type: Radial nephrectomy Histologic grade (Fuhrman): Grade 4 (with other areas of grade 3) Sarcomatoid features: Present (approximately 10%) Tumor size: 5.5 cm Extent: Directly invades renal sinus fat and renal pelvis 1cs-0:3 icovcmona, Popi1lany, Nenal ecll 83b0|3 Adrenal Gland: Not present in specimen Site: Kidaey, Nos Cl4.9 Angiolymphatic invasion: Absent Margins: All margins free of tumor 10/3/13 Lymph nodes: None present Pathologic stage: pT3 NX MX Non-neoplastic kidney: Multiple cysts with focal calcification. Patchy scarring and chronic pyelonephritis, likely related to tumor effect. Diagnosis Details: Comments: Tumor morphology is unusual and does not fit typical classification schemes. Some areas have papillary growth, others are more solid and infiltrative with irregular, infiltrative borders into the renal parenchyma. Numerous areas are solid with large epithelial cells with granular cytoplasm. Tumor. invades the collecting system which has been associated with more aggressive neoplasm.. Some features raise the possibilty of a translocation-associated carcinoma or possibly a hereditary. syndrome-type carcinoma. Immunostains for cytokeratin 1, P504, pancytokeratin, CD10, p63, and PAx-8 were performed. The tumor cells are positive for PAX-8 and P504. Pancytokeratin stains portions of the tumor strongly (the
+
+--- Page 2 ---
+papillary areas) but is negative in other areas. CK7 and CD10 are negative. p63 is negative. This immunostaining pattern is not specific and does not clarify the differential diagnosis further, other than. to confirm that is is a renal cell carcinoma. ADDENDUM REPORT The consultant opinion is that this tumor is best classified as a papillary renal cell carcinoma (type 2), with foci of sarcomatoid and rhaboid change. However, a renal cell carcinoma related to hereditary leiomyomatosis and renal cell cancer syndrome (HLRcc) cannot be excluded. To exclude this, clinical evaluation for cutaneous leiomyomas and genetic testing (can be performed on peripheral blood) for mutations of the fumarate hydratas gene are suggested. Formatted Path Reports: KIDNEY TISSUE CHECKLIST Specimen type: Nephrectomy Tumor site: Kidney Tumor size: 5.5 x 4.5 x 3 cm Focality: Single - Histologic type: Papillary adenocarcinoma Histologic grade: Undifferentiated Tumor extent: Extension to perinephric tissues Lymph nodes: Not specified Lymphatic invasion: Not specified Venous invasion: Not specified Margins: Uninvolved Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: The tumor cells are positive for PAx-8 and P504. CK7 and CD10 are negative. p63 is negative. Comments: Kidney- left
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diff --git a/output/text/92ab5b59-1baf-4209-83d0-e5a39dcd9dd8.txt b/output/text/92ab5b59-1baf-4209-83d0-e5a39dcd9dd8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e1cb725d640381360dbcb0a021bdd85b79d436fb
--- /dev/null
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+
+--- Page 1 ---
+UUID:4B77F18C-2A61-42E5-BF41-05FB9959EB3F TCGA-XN-A8T3-01A-PR Redacted tcD 0-3 C'deus careumno, derstNOS 8600|3 Site: Yoirssasheal C250 NATURE OF MATERIAL : PANCREAS J1[z9!J4 BIOPSY : MACROSCOPY - bottle 1 : specimen made of pancreatic head and segment of duodenum . The pancreas measures 6.0 x 4,5x 4,5 cm. The duodenum measuring 15.5 cm in length and diameter 2.5 cm. nIt was noted a head injury in pancreas, measuring 2.4 x 2,2 cm. - bottle 2 : gallbladder measured 12.2 cm length for 2.5 cm in diameter greater . - bottie 3 : 4 lymph nodes , measuring between 0.2 and 1.0 cm cm in major axes. MICROSCOPIC Product of pancreaticoduodenectomy: - invasive ductal adenocarcinoma localized in cephalic portion of pancreas, moderately. differentiated, measuring 2.4 cm. - foci of intraepithelial pancreatic neoplasms associated with high degree dysplasia / dcis. - presence of neoplasm infiltration and perineural associated with angiolymphatic embolization. - lack of infiltration neoplasm duodenal papilla - surgical margin committed by pancreatic neoplasms .. No metastasis in lymph nodes examined 15 ( 0 / 15 )  - Stage: pT2 pN0 . PATHOLOGISTS lw 1/8/13
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diff --git a/output/text/92d0feec-85d5-4c7c-81c4-dbef35c7d026.txt b/output/text/92d0feec-85d5-4c7c-81c4-dbef35c7d026.txt
new file mode 100644
index 0000000000000000000000000000000000000000..047a0a8b3278bb385bcf1aaac4b985c3640aff46
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID: 516173EA-A413-434E-9F9A-0A1A107C5B3C TCGA-KV-A6GD-01A-PR Redacted Surgical Pathology Report DATE OBTAINED: DATE RECEIVED: DATE REPORTED: CC DIAGNOSIS 1. SOft TISSUE, PERIReNAL FAT, EXcISION: FIBrOADIPOSE tISSUe WITH fOCAl ACUTE  INFLAMMATION; NEGATIVE FOR CARCINOMA. 2. RIGHt RENAL MASS, PARTIAl NEpHRECTOMy: PAPILLARy rENAL CELL CArCINOmA (SEE COmmeNt). zCD0:3 Histologic type: Papillary carcinoma, type 2 (chromophil cell) Sarcomatoid features: Not identifled Tumor Necrosis renal ceQ '8Q60f3 Present (~ 35%); see comment Tumor size: 6.5 cm Pth Fuhrman nuclear grade: Grade 2, focal 3. Tumor focality: Cecinone joaysQQsuy N8S Unifocal Macroscopic extent of tumor: Confined to renal parenchyma. 8Qso 3 Sit D%uney N6S Microscopic extent of tumor: Confined to renal parenchyma. Lymphatic/vascular invasion: Absent. C64.9 Margins: Negative parenchymal resection and perinephric soft tissue margins.. Non-neoplastic kidney: D 4/7/3 Renal parenchyma with patchy chronic inflammation and blood vessels with mild peripheral vascular disease. Adrenal gland: Not present. Lymph nodes: No nodes submitted. pTNM: pT1b AJCC STAGE: Stage I ***Electronically Signed Out**** COMMENT The tumor necrosis could have occurred spontaneously however it is associated with the prior core biopsy site, so biopsy-induced necrosis is also possible. Prior studies on the core biopsy. showed positive CK7 and positive AMACR consistent with. papillary carcinoma. #1 & #2: 88307, 88329 Clinical Diagnosis and History:  Right renal mass Tissue(s) Submitted: 1: PERITONEAL FAT  2: RIGHT RENAL MASS Page 1 of 2
+
+--- Page 2 ---
+Surgical Pathology Report. Gross Description: Specimen # 1 is received in formalin labeled perirenal fat and consist of a 8 x 8 x 1 cm fragment of adipose tissue partially surfaced by a glistening fascia. The specimen is serially sectioned to reveal no gross lesions. Representative sections are submitted in blocks 1A to 1B. Specimen #2 labeled right renal mass is received fresh for intraoperative consultation and consists of 195 grams, 9.5 (L-M) x 7.0 (S-l) x 6 cm (A-P) partial nephrectomy specimen. The specimen is inked blue in the parenchymal margin and black on the perinephric adipose tissue and then serially sectioned to reveal a 6.5 x 6.5 x 3.5 cm tumor ant about 4 mm to the parenchymal margin and confined to the renal parenchyma. The tumor cut surface is variegated and necrotic (approximately 35% necrosis). A . Representative sections are submitted as follows: small amount of tumor is procured for 2A: Perirenal fat 2B-C: Tumor to parenchymal margin.. 2D-E: Tumor to perinephritic fat.. 2G-H: Tumor to adjacent kidney and representative tumor. Intraoperative Consult Diagnosis.  MASS MEASURES ~4MM FROM THE CLOSEST PARENCHYMAL MARGIN Page 2 of 2 END OF REPORT
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diff --git a/output/text/93463df7-637e-4367-97a6-9f6ac1572669.txt b/output/text/93463df7-637e-4367-97a6-9f6ac1572669.txt
new file mode 100644
index 0000000000000000000000000000000000000000..08cbe0feb366c750069408b512c0eeca1353b23c
--- /dev/null
+++ b/output/text/93463df7-637e-4367-97a6-9f6ac1572669.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+Pathology Report. Patient: UUID:CA88491F-5572-480D-8E3D-D536E3CE5069 Specimen #: TCGA-A2-A4RX-01A-PR Redacted FMP/SSN: DOB/Age/Sex: Taken: Location: Received: Physician(s) : Reported: SPECIMEN: A: right axillary sent. node #1 and #2 B: right axillary sent. node #3 C: rt breast FINAL DIAGNOSIS: A. LYMPH NODES, RIGHT AXILLARY SENTINEL NODES #1 AND #2, EXCISION:  TWO LYMPH NODES, NEGATIVE FOR MALIGNANCY ON ROUTINE AND IMMUNOHISTOCHEMICAL STAINS. B. LYMPH NODE, RIGHT AXILLARY SENTINEL NODE #3, EXCISION:  ONE LYMPH NODE, NEGATIVE FOR MALIGNANCY ON ROUTINE AND IMMUNOHISTOCHEMICAL STAINS. C. BREAST, RIGHT, SIMPLE MASTECTOMY: pr<domNANt, p<r T3S MIXED EPITHELIAL/MESENCHYMAL METAPLASTICl CARCINOMA (CARCINOSARCOMA) .  HISTOLOGIC GRADE: 3, POORLY DIFFERENTIATED. TUMOR SIZE: 2.5 CM. jcs-0-3 MARGINS: NEGATIVE. i crcoma, mnetaplesHe, Ne s LYMPH NODES: SEE PARTS "A" AND "B". 8575/3 PATHOLOGIC STAGE: pT2(m) NO(sn). - HORMONE sTATUS: (Performed on specimen : ). Sitersrut,NOs ESTROGEN RECEPTOR: POSITIVE. c50.9 PROGESTERONE RECEPTOR: POSITIVE. - HER 2 NEU: NEGATIVE. " ! s. Comment: Three distinct masses were identified in the mastectomy specimen, all located in the lower outer quadrant. The two larger masses (#1 and #2) are histologically similar, showing a poorly differentiated epithelial component as well as a mesenchymal component displaying marked pleomorphism and fascicles of spindled cells. Staining of these biphasic. areas show strong pancytokeratin positivity in the epithelial component while the spindled areas are negative. The histologic and immunohistochemical pattern is consistent. with metaplastic carcinoma with a malignant sarcomatous component (carcinosarcoma).  While mass #1 and #2 are morphologically similar, they are not grossly or histologically contiguous. The third mass (#3) is a different histologic type (adenoid cystic carcinoma). It is also grossly separate from masses #1 and #2. As. per the AJcc Cancer Staging Manual, the grade and stage of multiple tumors of different histologic grade and/or type is based on the largest tumor Page 1 Continued on Next Page FOR OFPICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 2 ---
+Pathology Report Specimen #: Patient: FINAL DIAGNOSIS. (continued): (mass #1), as reflected above. Mass #3 is weakly ER positive (<5% of tumor nuclei staining). pR negative, and Her-2 neu negative (1+ staining). This case received intradepartmental peer review.. References: Edge SB, .Byrd. DR, .Carducci MA, Compton CC,.. eds. AJcc Cancer Staging Manual. 7th ed. New York, Ny: Springer; 2009. ****** Start synoptic report format .** Specimen: Total breast.. Procedure: Simple mastectomy.. Specimen laterality: Right. Tumor Site: Lower outer quadrant. Histologic type: * Mass #1: Mixed epithelial/mesenchymal metaplastic carcinoma (carcinosarcoma) . * Mass #2: Mixed epithelial/mesenchymal metaplastic carcinoma (carcinosarcoma). * Mass #3: Adenoid cystic carcinoma. Tumor size (dominant mass): 2.5 cm (measured grossly)..  Histologic grade (dominant mass) : - Glandular differentiation: 3. - Nuclear pleomorphism: 3. - Mitotic count: 2. - Overall grade: grade 3; score 8 of 9. Tumor focality: Multifocal.. *Number of foci: 3. *Sizes of individual foci: Tumor #1: 2.5 x 2.0 x 1.8 cm (measured grossly).  Tumor #2: 2.0 x 2.0 x 1.8 cm (measured grossly). Tumor #3: 1.1 x 0.8 cm (measured microscopically).  Ductal carcinoma in situ (Dcis): Dcis is present; high nuclear grade with central necrosis..  Lobular carcinoma in situ: Not identified. Specimen integrity: Single intact specimen. Specimen size (greatest dimension): 21.0 cm.  Margins: - Margins uninvolved by invasive carcinoma. - Distance from closest (deep) margin: 1.2 cm (slide c3, Mass #1). - Margins uninvolved by DcIs.. Distance from closest (deep) margin: 1.2 cm (slide c5).  Macroscopic and microscopic extent of tumor: Page 2 * Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 3 ---
+Pathology Report Patient: Specimen #: CLINICAL DIAGNOSIS AND HISTORY: F diagnosed with right breast IDc, stage 2 ER/pR weakly positive Her2 1+, that presents for preoperative evaluation prior to planned right mastectomy with SLNB. PRE-OPERATIVE DIAGNOSIS: POST-OPERATIVE DIAGNOSIS: Operative Findings: Post-operative Diagnosis:. GROSS DESCRIPTION: The specimen is received in formalin, labeled with the patient's name. A: lesignated "Right Axillary Sentinel Node 1 and #2 Right. portion of yellow-tan soft tissue. Sectioning reveals two pink-tan lymph nodes measuring 1.5 x 1.5 x 0.8 cm and 2.0 x 1.0 x 0.4 cm. ~Each lymph node is trisected to reveal a pink-tan cut surface that is otherwise unremarkable. The lymph nodes are entirely submitted as follows. first described lymph node. A2: second described iymph node. B. The specimen is received in formalin, labeled with the patient's name designated "Right Axillary Sentinel Node #3" and. lymph node is trisected to reveal an unremarkable cut surface. The specimen is entirely submitted in two cassettes.. C. The specimen is received in formalin, labeled with the patient's. name : designated "Right Breast" and consists of a right. mastectomy oriented with a short stitch superior and long stitch lateral. The specimen measures 21.0 cm from medial to lateral, 21.0 cm from superior to inferior and 4.0 cm anterior to posterior. The darkly pigmented superficial skin ellipse measures 6.2 x 4.5 cm and displays a centrally located everted nipple measuring 1.0 cm in diameter. No follows: deep margin = black superior surface of the lower outer quadrant = blue. Upon sectioning the cut surface is composed predominantly of yellow-tan lobulated adipose tissue admixed with approximately 20% dense pink-white fibrous tissue which is predominantly located in the central breast. discrete masses are identified in the lower outer quadrant. Mass #1 Two Page 4 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974S
+
+--- Page 4 ---
+Pathology Report Patient: Specimen #: FINAL DIAGNOSIS (continued): - Skin involvement: Not involved by carcinoma. - Nipple involvement: Not involved by carcinoma. - Skeletal muscle involvement: Muscle is not present Treatment effect: - In the breast: No known presurgical therapy. In the Iymph nodes:..No.known presurgical therapy..  Lymphvascular invasion: Not identified. Necrosis: Present within Dcis.  Microcalcifications: Identified within invasive and in situ carcinoma. Lymph Nodes:  Lymph nodes sampling: Sentinel lymph nodes. - Number of sentinel nodes: 3 Total number of lymph nodes: 3 Lymph nodes with macrometastasis (>0.2cm): 0.  Lymph nodes with micrometastasis (>0.2mm to 0.2cm): 0.. Lymph nodes with isolated tumor cells (<-0.2 mm): 0.. Size of largest deposit: Not applicable.  Extranodal extension: Not applicable.. Additional findings:  Intraductal papilloma.. - Biopsy site changes..  Ancillary studies: (Performed on - Estrogen receptor: Positive (1-5% tumor nuclei staining).. - Staining intensity: Weak..  Progesterone receptor: Positive (5% tumor nuclei staining).. -Staining intensity: Intermediate. - Her-2 Neu by IHC: Negative (score 1+). - Her-2 Neu by FisH: Not performed. Pathologic staging: Primary tumor: pT2(m) - Regional lymph nodes: pNo(sn)  Distant metastasis: Not applicable.. ** Report Electronically Signed Out * Page 3 Continued on Next Page FOR OFFICIAL USB ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 5 ---
+Pathology Report Patient: Specimen #: GROSS DESCRIPTION (continued) :) measures 2.5 x 2.0 x 1.8 cm. The cut surface is pink-tan and gritty. The mass is located 1.4 cm from the deep margin and 1.0 cm from the. superficial margin. Mass #2, also located within the lower outer. quadrant, measures 2.0 x 2.0 x 1.8 cm. : The mass is also well defined, pink-tan and gritty. Mass #2 is located 3.0 cm from the deep margin and approximately..1..0...cm.from . the. superficial.. surface....Mass..#2 is located anterior and medial to mass #1. 'The two masses are adjacent and yet appear discrete. The remainder of the lower outer and mid outer breast. shows a 5.0 x 3.0 x 2.5 cm area of dense pink-white fibrous tissue which is focally indurated (mass #3). On sectioning, the cut surface is. pink-white and otherwise unremarkable with no discrete lesions identified. No additional lesions are identified. No lymph nodes are identified. Representative sections are submitted in twenty-two cassettes as follows: c1: skin and nipple C2-c4: mass #1 with deep margin c5: mass #1 with superficial margin C6,c7&c8: additiona1 mass #1 c9&c10: intervening tissue between mass #1 and mass #2 C11:  mass #2 with superficial margin. C12: mass #2 C13: mass #2 with superficial margin C14: mass #2 c15, C16&c17: indurated fibrous tissue mid outer breast (mass #3) C18: upper outer quadrant c19: lower outer quadrant c20: lower inner quadrant c21: upper inner quadrant C22: central breast (some saved, three images taken labeled with mass #1 and mass #2) Mirrored images of mass #1 and mass #2 are submitted in paraffin and ocr per protocol. Time/Date of Specimen removal: unknown Time/Date in Pathology: Time/Date in formalin: Total time prior to fixation: unknown Time/Date out of formalin: Total fixation time:  28 hr 45 min Page 5 End of Report FOR OFFICIAL USE ONLY - PBRSONAL DATA - PRIVACY ACT OP 1974
\ No newline at end of file
diff --git a/output/text/934895c6-0c0c-4ee2-be4a-eb97606e26e9.txt b/output/text/934895c6-0c0c-4ee2-be4a-eb97606e26e9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..803f499f2761d3b29fc8f76b6a8d59dbe5ed09ba
--- /dev/null
+++ b/output/text/934895c6-0c0c-4ee2-be4a-eb97606e26e9.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis: 2. Resected section of colon (sigmoid) with an ulcerated colon carcinoma characterized histologically as a moderately differentiated colorectal adenocarcinoma, clearly extending up to 11 cm to the oral resection margin, measuring a max of 3 cm in diameter. Invasive spread of the tumor within all intestinal wall layers to the adjacent mesocolic fatty tissue. Otherwise the intestinal wall has several pseudodiverticula with chronic scarring peridiverticulitis. The preparation has a tumor-free seminal vesicle attached aborally. Oral and aboral resection margins are tumor-free. The tumor stage of the colon carcinoma described in (2) is therefore pT3, G2, RO.
\ No newline at end of file
diff --git a/output/text/934ca9a5-8d02-4bfa-a2bb-760959f25577.txt b/output/text/934ca9a5-8d02-4bfa-a2bb-760959f25577.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1c516fd76be1fd86221a987c6420421a6068d8ca
--- /dev/null
+++ b/output/text/934ca9a5-8d02-4bfa-a2bb-760959f25577.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+LcD-o-3 UUID:09FD99AA-10FF-4E45-9B21-2B3F7D8467580 TCGA-OR-A5L9-01A-PR Redacted Tunor, Adreua!Certical o-f. Site: Adlrena? Glavd, Corte. C74.d Procedure: most likely adrenalectomy. YO q/s13 Gross description: missing. Reference Pathology only:. Diagnosis: adrenocortical carcinoma, Kl67 5% Yf Cou ponis, WeUL Mut mri siHvly
+
+--- Page 2 ---
+Patient # from Tissue Source Site. Date of report Date of Surgery/specimen collection Site (confirmed to be adrenal) with laterality indicated Tumor size(s) Histologic diagnosis ACC Lymph Node Status  Pathologic nformation Weiss score
\ No newline at end of file
diff --git a/output/text/9388de2f-e03d-4c0e-9bad-809a3c7bed03.txt b/output/text/9388de2f-e03d-4c0e-9bad-809a3c7bed03.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d8b3e9ae412a14215d4643aebd5fbc3b751f4231
--- /dev/null
+++ b/output/text/9388de2f-e03d-4c0e-9bad-809a3c7bed03.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Light microscopic findings. 1. In relation to histology, an advanced carcinoma in block A is visible in the material at hand, severely necrotic here. Tumor cells are classified in relation to a colic. adenocarcinoma, specifically characteristic tubular formations, extensive necroses. as well numerous nuclear atypia.. The tumor is penetrating all wall layers as well as vessels, consistent with p T 1, L1,. V1. Only granulation tissue is visible in the region of the serosa. Tumor classification summary: ICDO-DA-M 8140/3 G 2-3 p T3 L1, V1 p N 0 Consistent with R0
\ No newline at end of file
diff --git a/output/text/93927d42-0a4d-4f51-b331-8cccf907bb98.txt b/output/text/93927d42-0a4d-4f51-b331-8cccf907bb98.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c93524d1934534f5159d55e4a799874d03b94c0e
--- /dev/null
+++ b/output/text/93927d42-0a4d-4f51-b331-8cccf907bb98.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Patient Key. Surgical date: TISSUE DESCRIPTION: Right lobe liver (1045 grams, 20 x 17 x 7.5 cm) and gallbladder (10 x 4 x 3 cm). A1, B1, B2, B3, B4, B5, B6, B7, B8, B9, B10, B11 DIAGNOSIS: Liver, right lobe, resection: Grade 3 (of 4) hepatocellular carcinoma, usual type forming a dominant 4.6 x 4.3 x 3.2 cm mass with a single satellite nodule measuring 0.4 cm in greatest dimension. The tumor is located in the right lobe. The hepatic capsule is free of tumor. The surgical margins are free of tumor. Extramural. vascular invasion is not identified. The tumor is not encapsulated, infiltration of parenchyma being of the pushing type. The non-neoplastic liver will be reported in an addendum. Gallbladder, cholecystectomy: Mild chronic cholecystitis ADDENDUM: The non-neoplastic liver shows mild tumor effect. No evidence of chronic or primary liver disease. UUID:AB7EF7A1-F8F1-404A-BF15-2CC53F63C033 CGA-DD-A39V-01A-PR Redacted /cs-0-3 carcnma hepihcllulu,nN0s 817s/3 Sifu hwje cs3.o hs 4/23/
\ No newline at end of file
diff --git a/output/text/93c881e1-6a9a-4a43-a979-6994f5460d24.txt b/output/text/93c881e1-6a9a-4a43-a979-6994f5460d24.txt
new file mode 100644
index 0000000000000000000000000000000000000000..63558c1edcd813351a0a5a02c9a50c7281dc0722
--- /dev/null
+++ b/output/text/93c881e1-6a9a-4a43-a979-6994f5460d24.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Pathology Report DIAGNOSIS (A) RIGHT KIDNEY AND ADRENAL GLAND: CHROMOPHOBE RENAL CELL CARCINOMA, FUHRMAN'S NUCLEAR GRADE 3. (SEE COMMENT) TUMOR CONFINED TO KIDNEY. TUMOR MEASURES 5.5 CM IN GREATEST DIMENSION. Vascular, ureteral and soft tissue margins of resection, free of tumor. COMMENT The immunohistochemical stains demonstrate that the tumor is focally positive for cytokeratin 7 and CD10 and negative for. vimentin. The electron microscopic examination demonstrates that the tumor is made of large polygonal cells with abundant cytoplasm containing numerous microvesicles and a moderate number of mitochondria with tubular cristae. The immunohistochemical profile and ultrastructural features of the tumor support the diagnosis of chromophobe renal cell carcinoma. The entire perinephric adipose tissue in the upper pole of the kidney is submitted for histological examination and no adrenal gland. is identified. GROSS DESCRIPTION (A) RIGHT KIDNEY AND ADRENAL GLAND - A nephrectomy specimen including kidney (12.0 x 7.0 x 4.0 cm), a portion of ureter (12.0 cm long and 0.5 cm in circumference) with attached perirenal fat. No adrenal gland is identified. A 5.5 x 4.8 x 4.0 cm, solid, circumscribed tumor is located in the upper pole of the kidney. The tumor is well circumscribed and grossly confined to the renal capsule. The tumor is close to the renal sinus but renal sinuses grossly not involved. The tumor has a. yellow-brown, variegated, solid cut surface. There is a 5.0 x 2.0 x 2.0 cm portion of fibroadipose tissue attached to the upper pole of the kidney. The fibrofatty tissue attached to the upper pole is serially sectioned and no adrenal gland tissue identified. INK CODE: black - Perirenal fat and fascia. SECTION CODE: A1, ureter and vascular resection margins, en face; A2-A12, tumor and upper pole fibroadipose tissue; A13-A15, tumor and renal capsule; A16, A17, tumor and renal sinus; A18, tumor; A19-A22, tumor; A23, random renal parenchyma;. A24, fibroadipose tissue; A25, ureter. CLINICAL HISTORY Right renal mass SNOMED CODES
\ No newline at end of file
diff --git a/output/text/93eac04c-8047-4b5b-b86a-9553aa039289.txt b/output/text/93eac04c-8047-4b5b-b86a-9553aa039289.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a632cc16f529a6288f190a2650a25e9d9528e1c3
--- /dev/null
+++ b/output/text/93eac04c-8047-4b5b-b86a-9553aa039289.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Formatted Path Report LARGE INTESTINE TISSUE CHECKLIST Specimen type: Colectomy Specimen size: Not specified Tumor site: Colon Tumor size: 9 x 8 x 2 cm Tumor features: None specified Histologic type: Adenocarcinoma Histologic grade: Moderately differentiated Tumor extent: Pericolonic tissues Lymph nodes: 12/12 positive for metastasis (Intraabdominal 12/12) Margins: Uninvolved. Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None
+
+--- Page 2 ---
+Date of Procurement
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diff --git a/output/text/9414fc12-f346-4872-ae01-dbf45d7d1887.txt b/output/text/9414fc12-f346-4872-ae01-dbf45d7d1887.txt
new file mode 100644
index 0000000000000000000000000000000000000000..84bbecaac4cdb392bc0ac72920fc6cf87db44159
--- /dev/null
+++ b/output/text/9414fc12-f346-4872-ae01-dbf45d7d1887.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+UUID:2D681585-7704-4D67-93D1-78EDD924F131 TCGA-A2-A4RY-01A-PR Redacted Age/Sex Location Unit# Status: Room/Bed Reg Disch. AttDr: Specimen : Received: Status: Req# Collected: Sp typ@: SURGICAL P Subm Dr: M.D. 1eD-0-3 PREOPERATIVE DIAGNOSIS Cxrcinomn, m`filtnahwg 1o bulw,N0s BREAST CANCER, BENIGN MAMMARY DYSPLASIA 8520/3 OPERATION PERFORMED Site: bunt; Nos...50.9 DATE : DOCTOR(S) : PROCEDURE :  MASTECTOMY MODIFIED RADICAL/TOTAL MASTECTOMY TISSUE REMOVED A. RIGHT AXILLARY LYMPH NODE LEVEL 2 B. RIGHT AXILLARY LYMPH NODE LEVEL 3 C. LEFT MASTECTOMY STITCH AT D. RIGHT MODIFIED RADICAL MASTECTOMY STITCH AT GROSS DESCRIPTION RECEIVED IN 4 PARTS. PART A RECEIVED LABELED RIGHT AXILLARY LEVEL 2 LYMPH NODES IS A NODULAR PORTION OF YELLOW FATTY TISSUE MEASURING 3.7 X 2.2 X 0.7 CM IN GREATEST DIMENSION.  FOUR FIRM OVOID STRUCTURES ARE IDENTIFIED MEASURING FROM O.4 TO 1 CM IN GREATEST DIMENSION. THE LARGER.NODES ARE EACH SECTIONED AND GROSSLY POSITIVE.  ONE-HALF OF EACH OF THESE IS SUBMITTED ALONG WITH THE UNSECTIONED SMALLER NODE LABELED A. THE REMAINING NODAL TISSUE IS SUBMITTED PER CLINICAL BREAST CARE PROJECT RESEARCH PROTOCOL LABELED P1-P3. PART B  RECEIVED LABELED RIGHT AXILLARY LEVEL 3 LYMPH NODE IS A FIRM O.8 CM IN GREATEST DIMENSION NODULE AND AN IRREGULARS PORTION OF NODULAR YELLOW FATTY TISSUE MEASURING 6 X 1.5 X 0.7 CM. FIVE FIRM OVOID STRUCTURES ARE IDENTIFIED IN THIS PORTION OF FATTY TISSUE. THREE OF THE NODULES ARE SUBMITTED UNSECTIONED LABELED B1. ONE-HALE FROM 2 SEPARATE GROSSLY POSITIVE NODES ARE SUBMITTED IN B2 WITH THE REMAINING TISSUE FROM THESE 2 NODES SUBMITTED AS P4. THE LARGEST NODE MEASURING 1.4 CM IN GREATEST DIMENSION IS GROSSLY FOCALLY POSITIVE. THIS IS SUBMITTED BISECTED AS B3. PART C  RECEIVED LABELEI LEFT MASTECTOMY STITCH AT 12 O'CLOCK IS A 131O GRAM SIMPLE MASTECTOMY MEASURING 23 CM FROM MEDIAL TO LATERAL, 23.5 CM FROM SUPERIOR TO INFERIOR, AND UP TO 5.5 CM FROM
+
+--- Page 2 ---
+atient Received: Status: Req#: Collected: Sp type: SU.3ICAL P Subm Dr: M.D. GROSS ANTERIOR TO DEEP. THE NIPPLE IS UNREMARKABLE WITHIN A 14 X 5 CM SKIN ELLIPSE. A SUTURE DENOTES 12 O'CLOCK. THE ANTERIOR ASPECT IS MARKED WITH BLUE INK, THE DEEP MARGIN WITH BLACK. SECTIONING REVEALS THE CENTRAL 5O% OF THE SPECIMEN TO CONSIST OF DENSE TAN FIBROUS TISSUE. THIS IS SURROUNDED BY A PERIMETER OF YELLOW FATTY TISSUE.  NO MASSES ARE . IDENTIFIED....REPRESENTATIVE . SECTIONS. ARE SUBMITTED AS. FOLLOWS: C1--NIPPLE, C2--CENTRAL DEEP MARGIN, C3 AND 4--UPPER OUTER QUADRANT, CS AND 6--UPPER INNER QUADRANT, C7 AND 8--LOWER INNER QUADRANT, C9 AND 1O---LOWER OUTER QUADRANT. ADDITIONALLY WITHIN THE CONTAINER AND INCLUDED THE WEIGHT ARE ADDITIONAL MULTIPLE IRREGULAR FRAGMENTS OF YELLOW-RED FATTY TISSUE IN AGGREGATE MEASURING 10 X 10 X 2.3 CM. SECTIONING REVEALS BLAND YELLOW FATTY TISSUE AND REPRESENTATIVE SECTIONS ARE SUBMITTED LABELED C11 THROUGH 13. NOTE:  MIRROR IMAGE SECTIONS OF THE NIPPLE ARE SUBMITTED AS P1S AND MIRROR IMAGE SECTIONS TO C3, C5, C7, AND C9 ARE SUBMITTED FROZEN IN OCT PER CLINICAL BREAST CARE PROJECT RESEARCH PROTOCOL. PART D RECEIVED LABELED RIGHT MODIFIED RADICAL MASTECTOMY STITCH AT 12 O'CLOCK IS A 146O GRAM RIGHT MODIFIED RADICAL MASTECTOMY. THE MASTECTOMY PORTION MEASURES 24.S CM FROM MEDIAL TO LATERAL, 26 CM FROM SUPERIOR TO INFERIOR, AND UP TO 6.5 CM FROM ANTERIOR TO POSTERIOR. THE AXILLARY PORTION MEASURES 10 X 9 X 2.5 CM. THE THE DEEP IS MARKED BLACK.  THE NIPPLE ANTERIOR MARGIN IS MARKED BLUE. IS UNREMARKABLE AND SITS IN THE MORE SUPERIOR PORTION OF THE SKIN ELLIPSE. THE SKIN ELLIPSE MEASURES 14 X 5.5 CM.  THE 12 O'CLOCK SUTURE IS JUST TO THE MEDIAL SIDE OF THE AREOIA. THE AXILLARY TAIL IS REMOVED AND RED INK IS PLACED IN THIS AREA TO INDICATE THAT IT IS NOT TRUE MARGIN.  UPON A QUICK PALPATION OF THE AXILLARY TAIL THREE ARE 3S PROMINENT STRUCTURES. THE 1ST IS A O.8 CM IN GREATEST DIMENSION LYMPH NODE WHICH IS GROSSLY NEGATIVE AND IS SUBMITTED BISECTED AS D1. THE 2ND IS A 2.S CM GROSSLY NEGATIVE NODAL STRUCTURE SUBMITTED BISECTED AS D2. THE 3RD STRUCTURE IS A 3.8 CM IN GREATEST DIMENSION GROSSLY POSITIVE LYMPH NODE OF WHICH ONE FULL CROSS SECTION IS SUBMITTED IN D3 AND 4. A COIL CLIP IS IDENTIFIED AND THE AREA OF THE CLIP IS SUBMITTED IN D5. THIS IS THE SAME NODE AS D3 AND 4. PORTIONS OF THIS LARGEST NODE ARE ALSO SUBMITTED IN P5 AND 6.  SECTIONING REVEALS THE CENTRAL PORTION OFS THE BREAST TO CONSIST OF DENSE TAN FIBROUS TISSUE AND THIS EXTENDS TO AN ILL-DEFINED GRAY-TAN MASS AT 9 O'CLOCK WHICH MEASURES 5.5 CM FROM MEDIAL TO LATERAL, 8 CM FROM SUPERIOR TO INFERIOR BY PALPATION, AND 4.5 CM FROM ANTERIOR TO POSTERIOR. GROSSLY IT IS 1 CM FROM BOTH THE ANTERIOR AND DEEP MARGIN.  SECTIONS ARE SUBMITTED AS FOLLOWS:  D6--NIPPLE, D7 THROUGH D9--SECTIONS OF DEEP MARGIN BENEATH LESION, D1O THROUGH D14--A CONTINUOUS SECTION OF THE LESION FROM SUPERIOR TO INFERIOR WHERE THE RED ENDS ARE
+
+--- Page 3 ---
+Continued) Specimen: Received: Status: eq#: Collected: Sp type: SURGICAL P Subm Dr: .D. GROSS DESCRIPIION (Continued) THE AREA WHERE THE ONE STRIP WAS SEPARATED FROM THE ADJACENT SECTION, D15--SECTION OF THE FAR LATERAL PORTION OF THE GROSS LESION, D16--SECTION FROM THE FAR MEDIAL PORTION OF THE GROSS LESION, DI7--TISSUE DEEP TO THE 5 CROSS SECTIONS, D18--TISSUE ANTERIOR TO TE 5 CROSS SECTIONS, D19--RANDOM SECTION OF LESION FROM THE MIDPORTION, D2O--RANDOM TUMOR INFERIOR.. EDGE,...D2....UPPER..INNER. QUADRANT.....CM...EROM..GROSS..TUMOR.,... D22--UPPER OUTER QUADRANT 3 CM FROM GROSS TUMOR, D23--LOWER OUTER QUADRANT 3 CM FROM GROSS TUMOR, D24-~LOWER INNER QUADRANT 5 CM FROM GROSS TUMOR. FURTHER EXAMINATION OF THE AXILLARY TAIL: EIGHTEEN (18) ADDITIONAL NODAL STRUCTURES ARE IDENTIFIED. THESE ARE SUBMITTED AS FOLLOWS: D25--6 NODES NOT SECTIONED, D26--ONE-HALF OF 2 GROSSLY POSITIVE LYMPH NODES PLUS 1 GROSSLY FAT REPLACED LYMPH NODE, BISECTED, D27--4 NODES, EACH BISECTED, D28--2 NODES, EACH BISECTED, D29--3 NODES, EACH BISECTED. SECTIONS PER CLINICAL BREAST CARE RESEARCH PROTOCOL ARE SUBMITTED FROM THE LYMPH NODE WITH THE CLIP LABELED P5 AND P6; TWO OF THE GROSSLY POSITIVE LYMPH NODES IN CASSETTE D26 AS P16; AND SECTIONS OF THE TUMOR AS P7 THROUGH P14 WITH MIRROR IMAGE SECTIONS FROZEN IN OCT OF P7, P8, P9, AND O13 AS WELL AS TISSUE FROZEN IN OCT AS MIRROR IMAGE TO THE NIPPLE (D6) AND OF THE RANDOM QUADRANT SECTIONS (D21 THROUGH D24). COMMENT :  THIS SPECIMEN EXCEEDS THE MAXIMUM CAP/ASCO GUIDELINE OF 48 HOURS FORMALIN FIXATION. ROCEDURES PROCEDURES: 88305/2, 88307, 88309, A BLK, B BLK/3, C BLK/13, D BLK/29 INAL DIAGNOSIS PART'A RIGHT AXILLARY LEVEL 2 LYMPH NODE SAMPLING: METASTATIC CARCINOMA CONSISTENT WITH LOBULAR CARCINOMA OF PRIMARY BREAST ORIGIN INVOLVING 4 OF 4 LYMPH NODES WITH THE TUMOR REPLACING 8O-90% OF THE CELLS IN EACH NODE AND THE LARGEST FOCUS OF TUMOR SPANNING A DISTANCE OF APPROXIMATELY 9 MM. PART B  RIGHT AXILLARY LEVEL 3 LYMPH NODE SAMPLING: METASTATIC LN evel 3
+
+--- Page 4 ---
+Con Specimen: eceived: Status: 3q# Collected:  Sp type: SURGICAL P Subm Dr: M.D. FINAL DIAGNOSIS (continuea) CARCINOMA IDENTIFIED IN 6 OF 6 LYMPH NODES. PART C LEFT MASTECTOMY: SKIN AND FATTY BREAST TISSUE WITH FOCAL Fcc FIBROCYSTIC CHANGES PRESENT. NO EVIDENCE OF MALIGNANCY OR ATYPIA. PART.....RIGH...MODIFIED..RADICAL .. MASTECTOMY.... MULTICENTRIC ..IN.. SITU. AND. Multiceutuc INFILTRATING LOBULAR CARCINOMA OF THE PLEOMORPHIC TYPE, NUCLEAR GRADE 2-3 OF 3 WITH A LOW MITOTIC INDEX WITH DOCUMENTED MICROSCOPIC EVIDENCE 1LC 3|3]] OF TUMOR SPANNING A DISTANCE OF AT LEAST 78 MM IN A SUPERIOR TO INFERIOR pleo DIRECTION.  THE TUMOR WAS 8 MM FRCM THE CLOSEST DEEP MARGIN. METASTATIC 7.8cn CARCINOMA IDENTIFIED IN 8 OF 20 AXILLARY LYMPH NODES WITH THE LARGEST FOCUS OF TUMOR SPANNING A DISTANCE OF 20 MM AND FOCAL MICROSCOPIC Omar PERINODAL SOFT TISSUE INVASION PRESENT.S 20Ln(leve) Enx Electronically signed by... M.D. Signed
\ No newline at end of file
diff --git a/output/text/94216f53-98f5-4e29-963c-49837a9e1900.txt b/output/text/94216f53-98f5-4e29-963c-49837a9e1900.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a49096d7a8c686b7e0e05d95320985700997e867
--- /dev/null
+++ b/output/text/94216f53-98f5-4e29-963c-49837a9e1900.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1c5-0 - 3 Carcinoma nucinous ardmiftmnhng duct 8573/3 Patient hIstORy: Site iod: brot,1owvr mner. quodrent C 50.3 The patient is a  year-old woman with a core biopsy in A showing infiltrating ductal carcinoma, mucinous type, nuclear grade 1 (ER and PR positive, and HER-2/neu negative). 19/1510 PRE-OP DIAGNOSIS: Right breast cancer; postmenopausal bleeding..  POST-OP DIAGNOSIS: Same. PROCEDURE: Right total mastectomy, sentinel node biopsy, hysteroscopy, D&C CQcF: Srast,nvs C50.9 FINAL DIAGNOSIS: Part 1: Breast,right, total mastectomy -  MULTIFOCAl iNFILTRATiNg DUCTAl CARCInOMA, MUCINOUS TYPE, INVOLVINg THe LOWeR INNER QUADRANT... B. THE TWO FOCi OF iNVASIVE CARCINOMA ARE BOTH 1.5 CM IN GREATEST DIMENSION. C. NOTTINghAm SCORE 4 (TUBULE fORmATION, 2; NUCLEAR PLeOmORPHISm, 1; MITOTIC InDEX 1). D.  DUctal CarcInoma In SItu (DcIS), SOLId TYpE, nuclEaR GraDE 1. : E. DCIS CONSTITUTES APPROXIMATELY 15% OF THE TUMOR MASS. F.  NO ANGIOLYMPHATIC INVASION IS IDENTIFIED. G.  SURGICAL MARGINS FREE OF CARCINOMA. H.  PREVIOUS BIOPSY SITE iS IDeNTIFIED. BenIgN BREAST tIsSUE. [. J.  SKIN AND NiPPLE NOT REMARKABLE. K.  One Lymph nODe nEgATiVE fOR CArcinOMA (0/1). UUID:E89670CB-575A-4867-AF79-1C73089886D4 TCGA-BH-A18S-01A-PR Part 2: Right AxiLLA, SentInel Lymph nOde#1, BIOpsy -- Redacted ONE LYMPH NODE NEGATIVE FOR MALIGNANCY (0/1). Part 3: endocervIx, Curettage - A. RARE BENIGN ENDOCERVICAL CELLS AND MUCUS. B. Negative fOr atypia Or CARcInomA. PART 4: ENDOmeTRIUm, CUReTTAgE -- A.  SCANT BENING ENDOMETRIUm WITH MUCUS AND CELL DEBRIES (CroSS refer : B. negative for atypia or Carcinoma. COMMENT: Estrogen and progesterone receptors and HER2/neu, performed on the previous core biopsy were reported as follows: ER positive, PR positive, HER-2/neu negative (score 1+).
\ No newline at end of file
diff --git a/output/text/944132da-1f72-4c24-bd13-af64d6cf8a83.txt b/output/text/944132da-1f72-4c24-bd13-af64d6cf8a83.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5c5d87862271b9b647c624eec9bf3ba0361d78ee
--- /dev/null
+++ b/output/text/944132da-1f72-4c24-bd13-af64d6cf8a83.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Date Coll: SURGICAL PATHOLOGY REPORT SPECIMEN A. Subtotal colectomy B. Small bowel mass C. Appendectomy CLINICAL NOTES PRE-op DIAGnosIs: Transverse colon cancer FROZEN SECTION DIAGNOSIS B. Serosal fibrosis, no tumor seen. on, further evaluation on permanent sections GROSS DESCRIPTION A. Received fresh in a container labeled "colon" is a segment of colon 23 cm long. The specimen is received open at both ends, which are arbitrarily inked blue and black.  The serosal surface is tan-pink and glistening. There is abundant attached yellow adipose tissue. present, 42 x 5 x 3 cm in greatest dimensions.. The omentum is serially s sectioned, and there are no focal lesions.  The segment of bowel is opened. It averages 6.5 cm in circumference. 5.5 cm fror the black- there tumor mass.  On cut surface, this tumor grossly invades into, and. apparently through, the muscularis propria, into surrounding soft tissues. Although extending near to the serosal surface, tumor does not appear to reach the serosal surface, and is not near the radial margin. is inked. 3.5 cm from the blue-inked margin is a separate 3.5 x 3.3 x 2.7 cm polypoid lesion. There is some black tattooing in this region. On cut surface, the polypoid lesion : the bowel wall. The specimen away from the lesions has a tan-pink glistening mucosa and tan wall. The adipose tissue is dissected,. and multiple tan lymph nodes are identified. Rs-22, following fixation. BLOcK suMMARy: A1,A2 - omentum; A3 - proximal and distal resection margins; A4-A7 - invasive tumor mass, with one lymph node also included in block A7; A8-A16 - entire polypoid lesion; A17-A22 lymph nodes. B. Received fresh in a container labeled "B - small bowel mass" is a portion of tan tissue with mucosa along one surface, 3 x 2 cm, and 0.3 cm deep, compatible with small bowel. On the serosal surface there is a tan-white plaque-like area, 0.8 x 0.5 x 0.1 cm.  A section is submitted for frozen section, including the submitted for permanent sections in three additional blocks. C. Received in formalin in a container labeled "appendix" is a 5.5 cm long x 0.7 cm in diameter appendix. It is grossly unremarkable, with a tan-pink glistening serosal surface, wall, and tan mucosa. There are no focal lesions.. AS-1.
+
+--- Page 2 ---
+MICROSCOPIC DESCRIPTION The following template summarizes the findings in this case: Histologic type:. Adenocarcinoma of the colon in part A, present in. the lesion submitted in blocks A4-A7.. Histologic grade:  Moderately differentiated. Primary tumor (pT): pT3.  Adenocarcinoma invades through the full. thickness of the muscularis propria into surrounding adipose tissue. Proximal margin:  Negative Distal margin:  Negative Circumferential (radial) margin:  Negative Distance of tumor from closest margin: See gross description Vascular invasion: Not definitively identified Regional lymph nodes (pN): pNlb. There is metastatic. adenocarcinoma in two of thirty-three (2/33) lymph nodes. One of the positive lymph nodes is the lymph node immediately subjacent to the tumor submitted in block A7. Non-lymph node pericolonic tumor:. Not identified Distant metastasis (pM) : pMX Other findings:  The separate polypoid lesion in part A is a. tubulovillous th focal severe dysplasia. Part A is also notable for Part B has serosal fibrosis, without tumor. seen. In pa appendix is without specific diagnostic. abnormalities, with luminal obliteration. Note: This case has been reviewed in Intradepartmental Consultation, with concurrence with the interpretation.. 5,4,1,14 DIAGNOSIS A. Colon, subtotal excision  Moderately differentiated adenocarcinoma, invading through the full thickness of the muscularis propria and into the surrounding adipose tissue (pT3, see microscopic. description).  Separate tubulovillous adenoma, with focal severe dysplasia.. Margins negative for malignancy. Metastatic adenocarcinoma in two of thirty-three (2/33) lymph nodes. B. Tissue, small bowel, excision Serosal fibrosis, no tumor seen. C. Appendix, excision  Luminal obliteration, without specific diagnostic. abnormalities. --- End Of Report --
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diff --git a/output/text/946a0f3d-79fd-4904-bd33-cb1dbe665313.txt b/output/text/946a0f3d-79fd-4904-bd33-cb1dbe665313.txt
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index 0000000000000000000000000000000000000000..f10a93a56512f982bbfde8230cc4593dad5f76fe
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+UUID: 4D4811FB-5BF1-4574-975B-1740602E43D80 TCGA-LL-A5YN-01A-PR Redacted RUN DATE: RUN TIME: PAGE 1 : Inquiry  RUN USER: PATIENT: ACCT #: LOC: U # AGE/SX ROOM: REG: REG DR: DOB: BED: DIS: STATUS: TLOC: SPEC #: COLL: TIME IN FORMALIN: 4:43 hrs. CLINICAL INFORMATION: Pre-Op Diagnosis: Remarks: Specimen(s) : A. Right breast lumpectomy C. Sentinel lymph node #2 B. Sentinel lymph node #1 D. Sentinel lymph node #3 IcD-o-3 MICROSCOPIC DIAGNOSIS Carc inomce,cluctal infiltratg itS 85001B A RIGHT BREAST LUMPECTOMY: Site RBreastuos INVASIVE DUCTAL CARCINOMA d5o.9 SEE COMMENT FOR DETAILS yJ 4/2113 B. SENTINEL LYMPH NODE #1: ONE BENIGN LYMPH NODE C. SENTINEL LYMPH NODE #2: ONE BENIGN LYMPH NODE D. SENTINEL LYMPH NODE #3: THREE BENIGN LYMPH NODES COMMENT(S) PROTOCOL FOR EXAMINATION OF SPECIMENS WITH INVASIVE CARCINOMA OF THE BREAST BASED ON AJCC/UICC TNM. 7TH EDITION The following classification should be adjusted based on additional clinical information. SPECIMEN: Partial breast PROCEDURE : Excision without wire-guided localization LYMPH NODE SAMPLING: Sentinel lymph nodes SPECIMEN INTEGRITY: Single intact specimen SPECIMEN SIZE Greatest dimensions: 10.5 x 9.5 x 4.5 cm SPECIMEN LATERALITY: Right TUMOR SIZE: Greatest dimension: 2.4 cm. TUMOR FOCALITY : Single focus of invasive carcinoma. EXTENT OF TUMOR: .- Skin: invasive carcinoma does not invade into dermis or epidermis Muscle: no skeletal muscle present. DUCTAL CARCINOMA IN SITU: DCIS is present *x CONTINUED ON NEXT PAGE **
+
+--- Page 2 ---
+RUN DATE: PAGE 2 Specimen Inquiry RUN TIME: RUN USER SPEC #: PATIENT: (Continued) comment(s) (Continued) Extensive intraductal component negative LOBULAR CARCINOMA IN SITU: Present HISTOLOGIC TYPE: Invasive ductal carcinoma. HISTOLOGIC GRADE : Tubular differentiation score: Nuclear pleomorphism score: 3 Mitotic count score:. 2 Overall grade: 3  MARGINS : Margins uninvolved by invasive carcinoma Distance from closest margin: 1.3 cm. superior Margins uninvolved by ductal carcinoma Distance from closest margin: 1.3 cm. superior LYMPH NODES Number of sentinel lymph nodes examined: Total number of lymph nodes examined: 5 Number of lymph nodes with macrometastases: 0 Number of lymph nodes with micrometastases: 0 Number of lymph nodes with isolated tumor cells: 0 PATHOLOGIC STAGING: Primary tumor: pT2 Regional lymph nodes: pNo (i-) Distant metastasis: not applicable GROSS DESCRIPTION: Received fresh for tissue banking and gross evaluation labeled with the patient's name A. and designated "right breast lumpectomy" is a 162 gram. 10.5 x 9.5 x 4.5 cm fibrofatty breast tissue biopsy. The biopsy has an overlying 8.5 x 2.0 cm black-brown skin ellipse. The ellipse is oriented as anterior. There is a short suture superior and a long suture lateral.  The margins will be inked per orientation as labeled: blue superior. black. inferior. yellow lateral, red medial and green deep or posterior. The biopsy is serially sectioned from lateral to medial to have a 2.4 x 1.8 x 1.5 cm tumor mass. The mass is centrally located within the specimen and is 1.3 cm from the nearest superior margin. is 1.5 cm from inferior. is at least 2.5 cm from deep as well as superficial and is more than.  cm from medial or lateral. The tumor has adjacent minor hemorrhage and fat necrosis. consistent with a previous biopsy. A section of tumor is sampled for tissue banking There is diffuse dense white fibrous tissue surrounding the tumor mass. The white fibrous : tissue has focal fibrocystic changes, and the white fibrous tissue makes up approximately 50% of the biopsy parenchyma. Representative sections are sampled from across the specimen to include tumor to the nearest margins as labeled:. A1 nearest perpendicular sections of lateral margin sampled. A2-A3 sections showing lateral dense white fibrous tissue with fibrocystic. change A4 section of tumor with adjacent petechial homorrhage A5 nearest deep margin. A6 nearest superficial skin margin A7 tumor to nearest inferior margin A8-A9 tumor to nearest superior margin A10 tumor with adjacent fat necrosis and petechial biopsy hemorrhage. A11 near full cross section of tumor sampled A12 perpendicular sections of medial margin sampled ** CONTINUED ON NEXT PAGE **
+
+--- Page 3 ---
+RUN DATE: RUN TIME : PAGE 3 Specimen Inquiry RUN USER SPEC #: PATIENT: (Continued) GROSS DESCRIPTION: (Continued) B. Labeled "sentinel lymph node #1" is a nodular. fatty 2.4 x 2.0 x 1.8 cm lymph node.. There is scant yellow adipose on the surface of the node. The node is serially sectioned perpendicular to the long axis to be entirely submitted per sentinel lymph node protocol in cassettes B1-B4. C. Labeled "sentinel lymph node #2" is a nodular. fatty 2.0 x 1.7 x 1.4 cm lymph node.. The fat is trimmed from the node, and the node is 1.2 x 0.7 x 0.6 cm. The node is sectioned perpendicular to the long axis to be entirely submitted per sentinel lymph node protocol in cassettes C1-c2. D. Labeled "sentinel lymph node #3" is a 3.5 x 3.0 x 1.5 cm aggregate of yellow adipose.. The adipose is sectioned to have three nodular lymph nodes. The nodes are 0.3 cm. 0.7 x 0.5 x 0.2 cm and 0.8 x 0.7 x 0.4 cm. The larger nodes are sectioned perpendicular to the long axis. and the nodes are sntirely submitted for sentinel lymph node protocol separately from smallest to largest in cassettes D1-D3. INTRAOPERATIVE CONSULTATION: INTRAOPERATIVE CONSULTATION. RIGHT BREAST LUMPECTOMY: GROSS TUMOR PRESENT. ADEQUATE FOR TISSUE BANKING WITH NEOPLASTIC TISSUE PROVIDED TO TISSUE BANK COORDINATOR SURGICAL MARGINS NEGATIVE WITH CLOSEST MARGIN SUPERIOR MEASURING 1.5 CM RESULTS GIVEN TO DR PHOTO IOCUMENTATION Image . Signed (signature on file).. ** END OF REPORT ** lw 3|s|3 3Tie[T3
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diff --git a/output/text/946e8a27-8a40-4f95-9692-9e9676616af9.txt b/output/text/946e8a27-8a40-4f95-9692-9e9676616af9.txt
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index 0000000000000000000000000000000000000000..e7688156d1ea92a8689f098f51f8cc1f6a5a991e
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+UUID:D3E87845-70EA-4641-BDCE-6961254E51080 TCGA-KM-A7QC-01C-PR Redacted MEDICAL RECORD Surgical Pathology Report Surgical Pathology Report. PATIeNT: MRN: ACCOUNT#: Received date: DOB: Procedure date: Age: sex: F SIGN-OUT DATE: ATTENDING: LOCATION: REQUESTING: CONTACT NO: (MD ) Room: COPIEs tO: LeD 0-3 DIAGNOSIS: Carcrons, Aovol eell 1. Lymph node, paraaortic (excision): Reactive lymph node. No tumor seen. Chromphole type 8B1713 Sue OKidreyios Ce4.9 2. Kidney, left base "mass" (excision): Necrotic debris. JJY9/241_3 3. Kidney, left, deeper base "mass" (excision): Kidney parenchyma. No tumor seen. 4. Kidney and adrenal, left, morcellated (nephrectomy-morcellated): Renal cell carcinoma, chromophobe type, *Furhman nuclear grade II with extensive necrosis and acute and chronic inflammation. Diffuse interstitial nephritis. Vascular and ureteral margins free of tumor. Focal ureteritis. No capsular invasion seen. Adrenal gland. No tumor seen. Note: Kidney Nephrectomy Summary Table Macroscopice Specimen Type:  Nephrectomy - morceilated Laterality: Left Tumor Size: 4.cm Focality: Unifocal Macro Extent of Tumor: Confined to kidney. Microscopic Histologic Type: Renal cell carcinoma, chromophobe type,. Histologic Grade: Furhman nuclear grade iI Patient Identification r age 1 of 3
+
+--- Page 2 ---
+MEDICAL RECORD Surgical Pathology Report Name: MRN: Date or Report: Extent of Invasion Primary Tumor(pT): pT1a Reglonal Lymph Nodes(pN): pN0 Distant Metastisis(pM): pMx Margins: Vascular, ureteral and inked surgical margins free of tumor. CLINICAL INFORMATION: Brief Clinical History: female wiht left renal mass Specimen Taken For Protocol: Allocate Order to Protocol: PRoceDure: Operative Findings: left upper pole mass Post-Operative Diagnosis:. left renal mass Pre-Operative Diagnosis: left renal mass. SPECIMENS SUBMITTED: 1. ROUTINE + 6FS, Peri-aortic lymph node (1FS) 2. SERIAL 5 + 6FS, Left kidney mass (2FS) 3. ROUTINE + 3FS, Left kidney mass (3FS) 4. KIDNEY, Left adrenal morgellated INTRAOPERATIVE CONSULTATION: 1. 1Fs Diagnosis: Lymph nodes, no definitive tumor seen on frozen section.. The Frozen Sections were performed by 2FS Diagnosis: Fragments of probable epithelioid tumor cells with coagulative necrosis; definitive characterization deferred to permanent.. 3FS Diagnosis: Portion of renal cortical tissue with focal mild interstitial inflammation, no definitive tumor seen on frozen sections. The-Frozen Sections were performed by GRoss DEscRipt Received are 4 formalin-tilled containers labeled with the patient's name, medical record number, and further described as follows: 1. "Paraaortic lymph node". The specimen is a tan to red/brown soft tissue fragment measuring 1.6 x 1.2 x 0.2 cm. The specimen is frozen in toto as 1Fs. in Surgical Pathology, the specimen is entirely transferred into an orange cassette labeled for permanent processing. Patient Identification Page 2 of 3
+
+--- Page 3 ---
+MEDICAL RECORD Surgical Pathology Report Nam MRN: Date of Report: 2. Left kidney mass base". The specimen is multiple (3) tan tissue fragments measuring 0.2 x .0.2 x 0.1 cm in aggregate. The specimen is frozen in toto. In Surgical Pathology, the specimen is transferred into an orange. cassette labeled for permanent processing. 3. "Left kidney mass deeper base". The specimen is a piece of red/brown tissue measuring 1.0 x 0.5 x 0.4 cm. The specimen is frozen in toto as 3Fs. In Surgical Pathology, the specimen is entirely transferred to an orange. cassette labelea for permanent processing. 4. "Kidney and adrenal -- morcellated" Received is a specimen labeled 'left kidney and adrenal morcellated". The specimen consists of a simple nephrectomy specimen three pieces measuring 16 x 10 x 5 cm in aggregate. The adrenal gland is identified. The ureteral and vascular structures are identified by surgical staples. The specimen is inked black and bisected revealing a 4 cm diameter tumor mass with a tan-yellow, soft, necrotic cut surface. 50% of the tumor is procured for . Representative normal is procured for Research. Procurement was performed by. on to  The vascular/ureteral margins are submitted in white cassettes 4A-C. The most distal end of the ureter is submitted in white cassette : 4D. Sections of the most inferior aspect of the tumor and kidney. inferior aspect of the tumor (most adjacent to the kidney) are submitted in white cassettes A section of adrenal gland is submitted in 4G Representative sections of fat are submitted in 4H. A representative section of normal kidney renal parenchyma is submitted in 4l. Representative sections of the tumor are also submitted in 4J-4Q for permanent processing. Gross dictated by  No consultants E Patient Identification. Page 3 of 3
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+SURGICAL PATHOLOGY REPORT Clinical Diagnosis & History: with a history of polyps and was under surveillance,. descending colon polyp biopsy showing invasive adenocarcinoma. Specimens Submitted: 1: sp: Left colon; extended hemicolectomy. DIAGNOSIS: 1. Sp: Left colon; extended hemicolectomy:. Tumor Type: Adenocarcinoma Histologic Grade: Moderately differentiated Tumor Location: Descending colon Tumor Size: Length is 3.5 cm Width is 2.2 cm Maximal thickness is 0.3 cm Tumor Budding: Absent Increased Tumor Infiltrating Lymphocytes:. Absent Precursor Lesions: Tubulovillous adenoma Deepest Tumor Invasion: Muscularis propria Gross Tumor Perforation:. Not identified Lymphovascular Invasion: Not identified Large Venous Invasion: Not Identified Perineural Invasion: Not identified Surgical Margins: Free of tumor Polyps/Mucosa Dysplasia (away from the carcinoma):. Tubular adenoma; number: 2 Non-Neoplastic Bowel: ** Continued on next page **
+
+--- Page 2 ---
+Page 2 of 3 Unremarkable Lymph Nodes: Number with metastasis: 0 Total number examined: 12 Tumor deposits in pericolorectal soft tissue: Not Identified Tumor Staging (AJCC 7th Edition): pT2 (Tumor invades muscularis propria) Lymph Node Stage (AJcc 7th Edition): NO (No regional lymph node metastasis) I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. 1.) The specimen is received fresh, labeled "left hemicolectomy, extended left stitch marks proximal " and consists of a segment of colon measuring 49 cm in length with a circumference of 4.5 cm at the distal resected margin. Focally hemorrhagic lobulated yellow tan adipose tissue spans the length of the specimen measuring up to 4 cm in thickness. The specimen i opened to reveal a mass lesion measuring 3.5 cm in length and 2.2 cm in width. The mass is located 36 cm from the proximal margin and 4.3 cm from the distal margin. Sectioning shows that the tumor invades the muscularis propria. The depth of invasion is 0.5 cm grossly. The remaining mucosa shows two small polyps measuring 0.3 cm in greatest dimensions located 17 cm proximal to the tumor. The attached adipose tissue is thoroughly examined and all identified lymph nodes are submitted. Representative sections of the specimen are submitted for permanent sections and for Tps. Summary of sections: P distal margin shave T - tumor P- polyps RS -representative sections LN - lymph nodes BLN - bisected lymph nodes ** Continued on next page **
+
+--- Page 3 ---
+Page 3 of 3 Summary of Sections: Part 1: Sp: Left colon; extended hemicolectomy Block Sect.  Site pCs D LN 13 2 1 T ** End of Report
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index 0000000000000000000000000000000000000000..1ac5ec81792793f8732c2012489993df2a36ea4d
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+Surgical Pathology Repon * Final Report * a cenone.,iy ststeg dus. Result type: Surgical Pathology Report 8s00fE Result date: Sits Result status: Signed Result title: Surgical Pathology Report Performed by: c sD 2 Verified by: g 75/3 Encounter info: * Final Report * Clinical History Right breast IDC at 12:00 position on prior core, ER+, PR+, HER2-. FNA of right axillary node was positive. UUID:A81EB5E0-305E-4657-94AD-0922CD1D79C60 Specimen TCGA-AC-A6NO-01A-PR Redacted #1 Right breast, stitch is lateral. #2 Right axillary contents. Gross Examination #1 Received fresh labeled right breast, stitch is lateral, is a lios gram, 21.5 x 20.0 x 6.5 cm simple mastectomy specimen,' oriented as stated above. There is a overlying 16.5 x 11.6 cm ellipse of brown skin with a normal appearing nipple and areola. There is no scarring or retraction on the skin surface. The deep margin is inked black and sectioning demonstrates a 17.5 x 12.0 cm ill-defined area of firm, gritty pink tan fibroglandular tissue, spanning all four quadrants. margin, (upper inner quadrant). within the gritty, nodular parenchyma there is a well circumscribed 4.0 x 3.5 x 3.5 cm white tan, indurated mass.  This mass is located subareolar, is 1.8 cm deep to the skin, 2.5 cm from the deep margin and at least 6 cm from all remaining margins. There are also four additional. smaller well circumscribed white tan, indurated masses, all within the upper inner quadrant. They range from 1.0-1.6 cm in greatest dimension. The closest smaller nodules in the upper inner quadrant is focally hemorrhagic One of the. (approximately 12:00-1:00 1ocation). The remainder of the tissue is composed of soft, lobulated adipose tissue intermixed with scant, delicate brands of fibrous tissue (sot and 20% respectively).  There are no apparent lymph nodes at the lateral pole and no. additional obvious masses are grossly seen. Fourteen sections are submitted in thirteen: "A-m". Block summary: "A", nipple and skin; "p", deep margin at closest approach to gritty nodular tissue (upper inner quadrant), perpendicular; subareolar mass; "g-h", four smaller masses in upper inner quadrant (one section per mass). focally hemorrhagic mass at 12:00-1:00 in "e":. aspect of gritty nodular tissue; "J", most lateral aspect of gritty nodular. "I", most medial Printed by: Printed on: Page 1 of 3 (Continued)
+
+--- Page 2 ---
+Surgical Pathology Report * Final Report * tissue; "k", gritty, nodular tissue from lower inner quadrant; "", gritty tissue from upper outer quadrant; "m, gritty tissue from lower outer quadrant. labeled right axillary #2  Received fresh, placed in contents, is a 9.o'x 7.0 x up to 2.5 cm aggregate of multiple irregular After fixation, multiple lymph fragments of tan yellow fibroadipose tissue.  Within the node candidates are identified up to 2.0 cm in greatest dimension... The largest candidate there is a focal firm, 0.s cm area of discoloration. candidates are submitted as thirty-three sections in fifteen: "A-o. Block summary: "A", representative cross section of abnormally firm lymph node "G*, one candidate bisected;. nH", one candidate trisected; "I-L", one candidate, bisected; "M-o", lymph node candidate, sectioned. Microscopic Examination #1,2  Microscopic examination performed. Comment The breast is extensively involved by Dcrs, over an area that spans all four Scattered throughout the Dics are quadrants and involves most of the breast.. four discrete foci of invasive ductal carcinoma, all with identical histology. Slgnature Line Signed by: ELECTRONIC Final Diagnosis #1 BREAST, RIGHT SIMPLE MASTECTOMY: MULTIFOCAL INVASIVE DUCTAL CARCINOMA, INTERMEDIATE GRADE. THERE ARE FOUR FOCI OF INVASIVE TUMOR, ALL WITH IDENTICAL HISTOLOGY. TUBULE FORMATION: MODERATE (SCORE 2). NUCLEAR PLEOMORPHISM: MODERATE (SCORE 2). MITOTIC COUNT: MODERATE (SCORE 2). TOTAL NOTTINGHAM SCORE: 6 OF 9 (GRADE II). LOCATION IN BREAST: LARGEST MASS IS AT 12:00-1:00 POSITION, THE FOUR SMALLER MASSES ARE ALL IN THE UPPER INNER QUADRANT. 1.0 CM, 1.0 CM. (SEE COMMENT) TUMOR SIZE: 4.0 CM, 1.6 CM, 1.5 CM, APPROXIMATLEY 9O*, RANGING PERCENT OF INTRADUCTAL CARCINOMA (DCIS) : FROM INTERMEDIATE TO HIGH NUCLEAR GRADE WITH NECROSIS. FIBROCYSTIC CHANGES. STATUS OF BREAST TISSUE AWAY FROM LESION: LOCAL LYMPHATIC SPACE STATUS: NEGATIVE. DERMAL LYMPHATIC SPACE STATUS: NEGATIVE.  NEGATIVE. SKIN AND NIPPLE SURFACE:  NEGATIVE (AT LEAST 0.9 CM). SURGICAL MARGIN STATUS: STATUS OF MICROCALCIFICATIONS: PRESENT IN DCIS. Page 2 of 3 Printed by: (Continued) Printed on:
+
+--- Page 3 ---
+Surgical Pathology Report * Final Report * ESTROGEN RECEPTOR ASSAY: POSITIVE ON PRIOR CORE (2+, 95%). PROGESTERONE RECEPTOR ASSAY: POSITIVE ON PRIOR CORE (3+, 95%). HERCEPTEST (HER-2/NEU) STATUS:  NEGATIVE ON PRIOR CORE (SCORE 1+). #2 LYMPH NODES, RIGHT AXILLA, DISSECTION: POSITIVE FOR METASTATIC CARCINOMA (2/16). SIZE OF LARGEST METASTASIS: O.8 CM, NO EXTRACAPSULAR EXTENSION. PATHOLOGIC STAGE (TNM CLASSIFICATION) : pT2 pN1a. Ordering Provider Ordering Physician: Printed by:  Page 3 of 3 Printed on: (End of Report) hw 7/3]
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diff --git a/output/text/94d15909-3852-4aff-be50-47cecec34da7.txt b/output/text/94d15909-3852-4aff-be50-47cecec34da7.txt
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index 0000000000000000000000000000000000000000..84b8683e509fcfbef47a33e6f02b7b19f8e03751
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+--- Page 1 ---
+Patient Name: Accession #: Med. Rec. #: Date of Procedure. DOR: Date ol Receipt: Gender: Date of Report Ref. Physician: Account #: Patient Address Billing Type Additional Copy to Ref Source sis & History: Ith large left renal mass. Specimens Submitted: 1: SP: Lefl kidney and ureter 2: SP: Para aortic lymph nodes. 3: SP: Preaortic lymph nodes. 4: SP: Suprahilar lymph nodes and adrenal gland DIAGNOSIS: SP: Left kidney and ureter: Tumor Type:  Renal cell carcinoma - Unclassified type The tumor is high grade with a combinalion of papillary, tubular and clear cell foaturos and focal desmoplastic stroma. Tumor Size: Greatesl diameler is 11.5 cm.. Local Invasion (lor renal cortical types): Involves renal sinus lat Tumor involves perinephric fat Renal Vein invasion: Not identified Surgical Margins: Free of tumor Non-Neoplastic Kidney: chronic pyelonephritis, nephracalcinosis and focal cortical scarring and cysts. Adrenal Gland: Not identified See pait 4 Lymph Nodes: Not identified Slaging for renal cell carcinoma/oncocyloma:  pT3a Tumor invades the adrenal gland or perinephric tissues but nol beyond Gerola's fascia Comment:  The tumor cells are diffusely irnmunoreactive for RACEMASE and CD10; and focally posilive for CEA, 34BE12. and CK7, CAlX and cytokeratin AE1-AE3 are negative in tumor cells. Page 1 ot 3
+
+--- Page 2 ---
+Para aortic lymph nodes; dissection: -Nine benign lymph nodes (0/9). 3.  Preaortic lymph nodes: - Ten benign lymph nodes (0/10) Suprahilar lymphinodes and adrenal gland:. 4. - Benign adrenat tissue. - No lymphoid tissue identified. TATTEST THAT THE A8OVE DIAGNOSIS I$ HASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Special Studies: Resull Spocial Stain Comment CK7 RACEMASE CA-1X. CD10 348E12 CEA P AE1:AE3 IMM RECUT NEG CONT Gross Description: 1)The specimen is received frosh fabeled "lelt kidney and ureter" and consisls of a kidney with attached ureler, renal vessels and. perinephric tat weighing 853 g in lotal. The kidney measures 17.5 x 11 x 9 cn. The atlached ureter measures 11 cm in length. and 0.3 cm in diameter. The atlached renal vein measures 1.4 Cm in length and 0.5 cm in diameter. The renal vessels and ureter margins are grossly unremarkable. An adrenal gland is not identified. The kidney is inked black and bivalved to reveal a hemorrhagic brght yellow to tan friable nass at the upper pole of the kidney mcasuring 11.5 x 0 x 8cm.. The mass is sharply circumscribed trom the adjacent kidney parenchyma and grossly extends into the perinephric fat and abuts Gerola's fascia which is inked black. Tunor exlends to within O.5 cn of the ronal sinus. Sections lhrough the remaindor of the kidney reveal a pink brown  parenchyna, with a well-detined corticomedullary junction and several cortical cysts filled with straw colored serous luid in the. inferior portion of the kidney measuring up to 2 cm in greatest dimension each.. The cortex measures 0.7 cm and the calyces. appear normat.  Lymph nodes are not identified in tho perinephric fat. The specimen is photographed. Representative sections are submitted lo id for permanent sections. Summary ol sections: UVM -- ureteral and vessel margins T-. tumor TPF-- tumor with perinephric fat TG - tumor with Gerota's fascia SF - sinus lat closest to tumor K -- representalive sections kidney C - cortical cysts 2). The specinen is received in formalin, labeled "Para-aortic lymph nodes" and consists of six pink tan frm, falty lymph nodes. ranging from O.5 to 2.7 cm in greatest dirmension. All identified lymph nodos are submitted.. Summary of sections: LN -- iymph nodes Page 2 of 3
+
+--- Page 3 ---
+BLN-- bisecled lymph node 3). The specimen is received in formalin, labeled "Preaortic lymph nodes" and consists of seven pink tan lirm, falty lymph nodes. ranging from 1 to 3.2 cm in grealest dimension. Allidontified lynph nodes are submitted.. Summary ol sections. LN -- lymph nodes 8LN-- bisected lymph node 4). 1he specimen is received in formalin, labeled *Suprahilar lymnph nodes and adrenal gland" and consists of a 8 x 3 x 2 cm. porlion of fibroadipose tissue. Cut sections reveal three yellow tan fatty lyrnph nodes varying lrom 0.7 to 1.2 cm. A cystic golden yellow adrenal membrane is identified , measuring 1.5 x 1.5 x 0.6 cm. All identified lymph nodes are submiltted.. Entirely submiltted.. Summary of sections: A -- adrenal gland LN - Iymph nodes Summary of Sections: Part 1: SP: Left kidney and ureter Block Sect. Site PC$ 4 add 4 c 1 K 3 SF 3 N T 4 2 TG 2 3 TPF uvm Part 2: SP: Para aortic lymph nodes Block Sect. Site PCs 2 8LN 2 2 LN 5 Part 3: SP: Proaortic lymph nodes Block Sect. Site PCs 2 BI.N 2 4 LN  Part 4:  sP: Suprahilar lymph nodos and adrenal gland. Block Sect. Site PCs 3 N A 3 LN 2 Page 3 of 3 END OF REPORT
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+:4FB4E64B-1E40-40D8-A90A-ECACC59657E3 1D-0.3 COrsinoma, hepeats sellulour NDS 817tL3 Site: duer C&3.D CLINICAL DIAGNOSIS: HCC SJs/191i4 Specimen : liver Gross Photo : GROSS: Specimen status: Fresh Operation: Central hepatectomy Cholecystectomy Organ: Liver (15.0 x 11.8 x 6.8 cm, 791.0 gm) Gallbladder (8.2 cm in length, 3.2 cm in diameter) Lesion: Huge hepatic mass - Size: 7.5 x 7.3 x 5.3 cm - Cut surface: Relatively well-demarcated and encapsulated yellowish tan, lobulated, solid and extensive necrosis Gross type: Multinodular confluent - Extent: Confined to the capsule Resection margin: Not involved, grossly (safety margin: 0.2 cm) Remaining parenchyme: Unremarkable [Gallbladder] Serosal surface: Yellowish green and smooth Mucosal surface: Dark green and velvety Wall: 0.2 cm in thickness Representative sections are submitted. Gross photo: Present Blocks T1-4, tumor mass of liver x 4 RM, tumor with resection margin x 1 L, nontumorous liver parenchyme x 1 GB, gallbladder x 1 MICROSCOPIC: Tumor type: Hepatocellular carcinoma The worst differentiation III The major differentiation III Histologic type: Trabecular, tubular, and solid Cell type: Hepatic Fatty change: Yes Cholangiocarcinoma: No
+
+--- Page 2 ---
+Fibrous capsule formation: Yes Capsular infiltration: No Septum formation: Yes Surgical resection margin invasion: No Serosal invasion: No Portal vein invasion: No Vascular invasion: No Bile duct invasion: No Remaining liver parenchyme: Chronic hepatitis: Yes Etiology: HBV Grade, lobular: Mild Grade, portoperiportal: Mild Stage (fibrosis): Septal Cirrhosis: No Dysplastic nodule: No NOT reported. Gross: liver, needle, viral hepatitis liver,ectomy,hepatocellular carcinoma T56000, P10, M81703 gallbladder,ectomy,chronic cholecystitis T57000, P10, M43005 DIAGNOSIS: Liver, left, central hepatectomy: Hepatocellular carcinoma Gallbladder, cholecystectomy: Chronic cholecystitis Suggestion :
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diff --git a/output/text/95184dcb-c526-4872-98c0-b226147cd803.txt b/output/text/95184dcb-c526-4872-98c0-b226147cd803.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4f15d4fafeecb925e45c57ac03e7208f631c826d
--- /dev/null
+++ b/output/text/95184dcb-c526-4872-98c0-b226147cd803.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+FINAL DIAGNOSIS: Part 1: breASI, RIght, SEgmental mAstectOmy -- A.  INFILtrATiNG DUCTAL CArCiNOMA, nOTTiNghAm GRADE 3 (tUBULE fORmATION 3, NUCLEAR GRADE 3, mITOTiC GRaDe 3; tOTAL SCORE 979) B. Ductal carcinoma in-situ (dcis), nuclear grade 3, sOlid type wIth Comedo necrosis. C.  DCiS IS ADMIXED WITH iNVASIVE COMPONENT AND COMPRISES APPROXIMATELy 10% Of THE tOTAL TUMOR VOLUME. D. THE InVASIVE COMPONeNT MEASURES 2.5 CM iN GREATESt DImENSION. E.  NO DEFINITE LYMPHOVASCULAR iNVASION IS IDENTIFIED. F.  MARGINS OF RESECTION ARE NEGATIVE, INVASIVE CARCINOMA IS 0.7 CM AWAY FROM THE CLOSEST (SUPERIOR) MARGIN. G. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES WiTH APOCRINE METAPLASIA AND SCLEROSING ADENOSIS. H. BIOPSY SITE CHANGES. 1.  SKIn, NEgative fOR tumOR. J. INVASIVE TUMOR IS NEGATIVE FOR ESTROGEN AND PROGESTERONE RECEPTORS AND HER-2/NEU (SCORE 1+) AS pEr prevIOUs pathOLOgy RepOrt PARt 2: RIght AXILLARy #1 SEnTineL Lymph nODE, BiOpSy -- 1cs-0 -3 A. One Lymph nOde, pOsItive fOR tumoR (1/1). Chvcmoma, ripilt^tMs duetl Nos 85r0f3 B. the Size Of the lymph node metastasis is 0.7 cm. PARt 3: Right AXiLLARy #2 SEntineL Lymph nODE, BIOpSy - ONe Of THrEe LyMph nODeS, POSITiVE fOR tUmOR (1/3). CASE SYNOPSIS: SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREASTE LATERALITy: Right proceDure: LOCATION: Segmental Not specified SIZE OF TUMOR:  Maximum dimension invasive component: 2.5 cm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: No TUMOR TYPE (invasive component): Ductal adenocarcinoma, NOS, Other Type(s): basal-like phenotype NOTTINGHAM SCORE: Nuclear grade: 3 Tubule formation: 3 Mitotic activity score: 3 Total Nottingham score: 9 UUID:A6E2735B-AAD3-48D7-8289-306257CB5B6F Nottingham grade (1, 2, 3): 3 TCGA-BH-A0B3-01A-PR Redacted ANGIOLYMPHATIC INVASION: No DERMAL LYMPHATIC INVASION: No CALCIFICATION: No Tumor type, in situ: Solid DCIS admixed with invasive carcinoma. Percent of tumor occupied by in situ component: 10 % SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:E No Distance of invasive tumor to closest margin: 7 mm SURG MARGINS INVOLVED BY iN SITU COMPONENT: No LyMPH NODES pOSITIVe: LyMPH NODES EXAMINED: 2 MEtHOD(S) OF Lymph nODE EXAMinATION:  H/E stain SENTINEL NODE METASTASIS: Yes SIZE OF NODAL METASTASES: Diameter of largest lymph node metastasis: 7 mm LYMPH NODE METASTASIS(-ES) WITH EXTRACAPSULAR EXTENSION: t stage, pathologic: No N Stage, PathoLOgIC: pT2 pN1a M Stage, patholOgIC: ESTROgen RECePTORS: pMX PROGESTERONE RECEPTORS: negative negative HER2/NEU: zero or 1+ ual/Syr.c
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diff --git a/output/text/951ff4f2-2531-418f-aa86-db1f35e3a316.txt b/output/text/951ff4f2-2531-418f-aa86-db1f35e3a316.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0ef516f4c5c5380082557727ffc3dadacd8d4ca4
--- /dev/null
+++ b/output/text/951ff4f2-2531-418f-aa86-db1f35e3a316.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+ID-O-3 UUID: 29F3D730-2FE0-4490-B09E-22A90A36B9FA CGA-V4-A9EZ-01A-PR Redacted Rpinsle eIl rmieL a77cJ3 C Sub Crus( c69.3 eatk. LvexQ tse1 Ck9 4 Enucleation of the right eye.. Macroscopy: The eyeball measures 23 mm in diameter and the posterior optic nerve segment 10 mm. Tumor specimens have been taken for cryopreservation then the piece has been fixed and included entirely.. Su path dis crpersy fom fyr lpithelioid. ord Spindl ell nato. Microscopy The eyeball presents a tumor with the histological features of an uveal melanoma composed mainly of fusiform cells (70%) with a few epithelioid cells (30%). The. mitotic activity is very low.. The tumor is located at distance of the optic nerve which is free on its entire course. The cut end of the optic nerve and the meningeal sheaths are also free. There is a focal infiltration of the 1/3 inner part of the sclera, without extra-scleral extension. The ciliary body is free of tumor. Conclusion: Uveal melanoma mainly composed of fusiform cells with rare epithelioid cells. Tumor size: 15 mm.. Focal infiltration of the inner third of the sclera without extra-scleral extension. Ciliary body, optic nerve on its entire course and its cut end and meningeal sheaths free of tumor. 1/30/13
+
+--- Page 2 ---
+V4.00 TCGA Pathologic Diagnosis Discrepancy Form Instructions: The TCGA Pathologic Diagnosis Discrepancy Form should be completed when the pathologic diagnosis. documented on the initial pathology report for a case submitted for TCGA is inconsistent with the diagnosis provided on the Case Quality Control Form completed for the submitted case.. Tissue Source Site (TsS): --. TSS Identifier:_  TSS Unique Patient Identifier: _ Completed By (Interviewer Name on OpenClinica): . Completed Date:  Diagnosis Informatlon Data Element Entry Alternatives Working Instructions  30% epithelioid cells Provide the diagnosis/histologic subtype(s) documented on Pathologic Diagnosis the initial pathology report for this case. If the histology for Provided on Initial this case is mixed, provide all listed subtypes. 70% spindle cells Pathology Report Histologic features of  Provide the histologic features selected on the TCGA Case 61-90% epithelioid cells Quality Control Form completed for this case. the sample provided for TCGA, as reflected 1-30% spindle cells on the CQCF. Discrepancy between Pathology Report and Case Quality Control Form Provide the reason for Provide a reason describing why the diagnosis on the initial the discrepancy The section of the frozen sample used for sending  pathology report for this case is not consistent with the  between the pathology to TCGA corresponds to a section of the tumor diagnosis selected on the TCGA Case Quality Control Form. report and the TCGA where the epithelioid part is predominant. Case Quality Contro! Form. The percentages mentioned on the initial  Pathology Report correspond to an average on the whole embedded sections used for establish the Pathology Report. Name of TSS Reviewing Provide the name of the pathologist who reviewed this case for TCGA. Pathologist or  Biorepository Director I acknowiedge that the above information provided by my institution is true and correct and has been quality controlled.. TSS Reviewing Pathologist or'Biorepository Director Date I acknowledge that the above information provided by my institution is true and correct and has been quality controlled. The Attending Pathologist or the Department Chairman has been informed or is aware of the ahove discrepancy in diagnoses..  Principal Investigator Signature Date
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diff --git a/output/text/9538d923-9027-4f4e-a283-ae16c9d7f1fa.txt b/output/text/9538d923-9027-4f4e-a283-ae16c9d7f1fa.txt
new file mode 100644
index 0000000000000000000000000000000000000000..75c093e0f86c4019ac4e4c409fe50af54ff0483a
--- /dev/null
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@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+Clinical  Date of ! Specimen Ethnicity  Clinical DOB Index Case # Site # Sex (Race) 'procuremen! label : Diagnosis : (mm/dd/yyyy) Colorectal cancer Colorectal cancer
+
+--- Page 2 ---
+Tissue . Anatomical !  Tumor Specimen Specimen : Number of ' Amount/per! Unit I Specificatio I Matrix  Container  Site Location Format I containers : container : n Colon  Primary Tumor Tissue Frozen cryomold 1 260 mg  Blood n/a  normal  Blood Frozen tube 1 4 ml
+
+--- Page 3 ---
+ Prior Type of Chemo/ Histological ! TNM Stage : I TNM Stage : : TNM Stage ! Chemo / Prior 'Procuremen! Grade Horm Th description (T) (N) (m) : Hormonal Radiation Details Th  Surgery Adenocarcinoma 3 3 0 no no no  Blood draw n/a n/a n/a n/a n/a no  no no
+
+--- Page 4 ---
+Cellular Tumor % 70 n/a
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diff --git a/output/text/9538f938-70d1-488b-9273-f9fa502b82b5.txt b/output/text/9538f938-70d1-488b-9273-f9fa502b82b5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e5b10268125662ecccddeaa4334ae60705823a5f
--- /dev/null
+++ b/output/text/9538f938-70d1-488b-9273-f9fa502b82b5.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UUID:4F3E197A-9731-427C-A2A8-2D506A1C717B TCGA-C8-A278-01A-PR Redacted IrB ApprOVeD MultI-media Systems, Inc. Form Revised Clinical Case Report 1cs-0-3 (For Collection of Cancerous Tissue). Carcinoma infiltratirg duct, Nos 8500/3 Srfs: Lresst,Nos C50.9 L 5/7ufu Informed Consent I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator. Signature Date Clinical Information .WRGENERALINFORMATION Data of Birth (mm/dd/yyyy) Height Marital Status Race Temperature Single Married 37c Gender Welght  Divorced  Widow Blood Pressure Heart Rate  Male Female 42v78o mm 1] 88 0m 0 EPRA SAATSAHISTORYORPRESENTILLNESS Chief Complaints: htuiit beag# Symptoms: Dhe.t F hReaet me nmta ago thee Clinica! Findings: - the Gw podas asg euiarue. Performance Scale (Karnofsky Score):  100 Asymptomatic   80-90 Symptomatic but Fully Ambulatory   60-70 Symptomatic, in bed less than 50% of day  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden.  20-30 Bed Ridden AE  W   CURRENT MEDICATIONS  Drug Dose Route Frequency Date (mm/dd/yyyy) To N0 To To To To
+
+--- Page 2 ---
+PAST MEDICAL HISTORY Diagnosis/Disease/Disorder/Injury  Diagnosis Date Treatment Status 1 ape*** whwW.OB/GYNHISTORY .w..w.W. Menopausal Status Date of First Menses # of Pregnancies  Pre-menopausal yeas-e!  Peri-Menopausal Date of Last Menses # of Live Births Post-menopausal yeasrlel Birth Control:  Condom  Oral Contractpuve  IUD  Hormone Replacement  Other: Therapy: w.pSOCIAL.HISTORYei Occupation: Environmental Hazards: Smoking History Current Status TypE  Packs/day Duration When Quit yES ANO (yrs) (yt). Alcohol Consumption Current Status TYPE Drlnks/day Duratlon When Quit  yes no (yrs) (yr) Drug Use Current Status TyPE Freguency. Duration When Quit  yES ANO (yrs) 1 (vr ETMS FAMILYMEDICALHISTORYM  *ESN Relative Dlagnosis Age of Diagnosis AARALABDATAA Test Result  Date Test Result Date HIV Negative  Positive: CEA  Negative  Positive: Hep B Negative  Positive: CA 15-3  Negative  Positive: Hep C CA 19-9   Negative  Positive:   Negative  Positive: AFP  Negative  Positive: PSA   Negative  Positive: Other: Other:  Negative  Positive:  Negative  Positive: B/T Cell Markers:
+
+--- Page 3 ---
+DIAGNOSTIC STUDIES Study  Results Date Ultrasound X-Ray   CT Endoscopy MRI Biopsy BL WAM MCLINICALDIAGNOSIS  N  Preoperative Clinical Diagnosis Deast Cauer Location of Suspected Involved Lymph Nodes. Location of Suspected Distant Metastasis. Axlla NO Clinical Staging Date of Diagnosis Tg N1 Mo Stage: PR Treatment Information AAMASURGICALTREATMENTRC Procedure Date of Procedure Ya teu's hrm Primary Tumor Organ Detalled Location Size Rgeat Loxrs Ga ls 19.5x V x cm Extenslon of Tumor ND Lymph Nodes Description Location of Lymph Nodes # of Lymph Nodes Palpable, Non-Dissected Lymph Nodes 6 Dissected Lymph Nodes Distant Metastasis  Organ Detalled Location Size Surgical Staging A T9 No. M o Stage:  NEOADJUVENTTHERAPY (Chemo, Radiation, Immuno, Hormonal, or Molecular). .. . Drug/Treatment Dose Route Frequency Date (mm/dd/yyy) To NO To / To To To
+
+--- Page 4 ---
+Pathology Form Specimen Information Date: Time: Collected by: Preserved by: Date:  .me: MSPECIMEN TYPE #Of.samples provided  Paraffin Block Biooa/Serum/Plasma Slide Frozen Normal Diseased-  Normal Diseased Normal Diseased  Normal Diseased Time to Formalin. Time to LN2 Time to LN2 min 60 min g No min BMPATHOLOGICALDESCRIPTIONAAAAS Primary Tumor Size Extension of Tumor Distance to NAT Organ Raeat 9.5x cm cm Lymph Nodes # Examinedd # Metastasized Location Axill. 6. 6 Distant Metastasis  Size Organ Detailed Location NU Pathologica! Staging Ny M o Stage: WLA pT 9 Notes:
+
+--- Page 5 ---
+CONsoLIDated DIagNostIc pathoLOgy foRm* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION Diffuse STRUCTURAL PATTERN Mosaic X Streamin Necrosis X  Storiform Lymphocytic infiltration x Fibrosis Vascular Invasion X Palisading Clusterized XCystic Degeneration Alveolar Formation X Bleeding Indian File Myxoid Change 2. Cellular features:  Psammoma/Calcification Souamous + Adenomatous Sguamoid Cell + Sarcomatous Glandular cell Lymphomatous Splnd!e Cell X Round Cel! Cell Stratification Larre Cell Keratin M Fibroblast Small Cell Secretion Desmosome Osteoblast RS CeIl/RS Like Intracyt. Vacuole Lipoblast Pear! Inflam. Cell Giand formation Myoblast Plasma Cell Otherwise Specified: D7O7 bz7oZ Meesrs 2. Cellular Differentiation: Well Moderaely Poor Nuclear Atypia: Nuckar Appearance 11 Aniso Nucleosis Hyperchromatism Nucleolar Prominent Multinucleated Giant Cel! 9 Mitotic Activity Nuckear Grade Histological Diagnosis: iofilt&g /ny Dsetal Caecrm, Ats., G2 M, M2 caAtrmg rla? tgsBed to 2N Comments: Date Director, Research Pattoiogy PATHOLOGIST STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CONTRISUTOR ANO .
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diff --git a/output/text/953c3e7d-9dd0-46e1-954a-6db07c49cd89.txt b/output/text/953c3e7d-9dd0-46e1-954a-6db07c49cd89.txt
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index 0000000000000000000000000000000000000000..9f62452be6ded80eadf494d39d8ac493b4e857b9
--- /dev/null
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+
+--- Page 1 ---
+UUID:7BDC2B9E-DB52-4D92-9712-CBE3B6A67706 TCGA-DK-A3IU-01A-PR Redacted SURGICAL PATHOLOGY REPORT ** Patient Name: Accession #: Med. Rec. #: Date of Procedure:  DOB: (Age: Location: Date of Receipt: Gender: M Service:  Urology Date of Report: Ref. Physician: Account #: Patient Address: Billing Type: INPATIENT Additional Copy to: Ref. Source: Clinical Diagnosis & History: /ear old male with recurrent high grade T1 urothelial carcinoma. Specimens Submitted: 1: Urethral margin (fs) 2: Right distal pelvic lymph node 3: Left distal pelvic lymph node 4: Bladder, prostate, seminal vesicles and perivesicle lymph nodes; cystoprostatectomy 5: Left distal ureter 6: Right distal ureter DIAGNOSIS: Ics- 0- 3 1. Urethral margin; excision:. - Benign urethra and prostate tissue. corcinsma lrcjhelil,Nis 812cf3 Site: b1addev, wnll.poster' cl'T 4 2. Right distal pelvic lymph node: Lymph Node Dissection: lw 12/7/r Benign lymph nodes Number of lymph nodes examined: 11 3. Left distal pelvic lymph node: Lymph Node Dissection: Benign lymph nodes Number of lymph nodes examined: 3 Bladder, prostate, seminal vesicles and perivesicle lymph nodes; cystoprostatectomy: a. Tumor Type:  Invasive urothelial carcinoma, NOS Histologic Grade: High grade Pattern of growth of the Non-Invasive component: In situ component not identified Pattern of growth of the Invasive component:  Infiltrating Tumor Multicentricity:. 72777 Not identified Page 1 of 6
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT Bladder Local Invasion: Deep half of muscularis propria Extravesical Tumor Extension: Ureters uninvolved Urethra uninvolved Vascular Invasion: Identified Perineural Invasion: Identified Surgical Margins: Free of tumor Non-Neoplastic Mucosa: Exhibiting ulceration Exhibiting foreign body reaction Prostate: Other See section b Seminal Vesicles: Not involved Perivesical Lymph Nodes: LN Not involved 1 The Pathologic Stage is (AJCC 2002): pT2b (Invades deep half of muscularis propria) PR0 (No involvement of prostate) Tumor Type: Adenocarcinoma of prostate Gleason's Grade:  Primary Gleason grade:3 Secondary Gleason grade:3 Total Gleason score:6 Tumor Location: Involves Right posterior  Involves Left posterior Involves Left anterior Dominant tumor mass located in: left anterior and posterior mid Vascular Invasion: Not Identified Perineural Invasion: Identified Tumor Multicentricity: Multicentric foci of invasive carcinoma are present High Grade Prostatic Intraepithelial Neoplasia: Identified Capsule: Tumor invades into, but not beyond prostate capsule Seminal Vesicles: Page 2 of 6
+
+--- Page 3 ---
+SURGICAL PATHOLOGY REPORT Not involved Bladder Neck: Not Involved Surgical Margins: Free of tumor Non-Neoplastic Prostate: Exhibits nodular hyperplasia Staging (AJCC 1997): pT2b (confined to the prostate & capsule, involving both lobes) Left distal ureter; excision: - Benign ureter. Right distal ureter; excision: 6 - Benign ureter.. 1 ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. *** Report Electronically Signed Out *** Special Studies: Result Special Stain Comment RECUT RECUT RECUT Gross Description: 1. The specimen is received fresh, labeled "Urethral margin", and consists of one piece of tan soft tissue measuring 2.0 x 0.8 x 0.3 cm.The specimen is entirely submitted for frozen section diagnosis. Summary of sections: FSC -- frozen section control 2. The specimen is received in formalin, labeled "right distal pelvic lymph node", and consists of a piece of adipose tissue. The specimen is dissected to reveal multiple pink tan firm lymph nodes ranging from 0.3 x 0.3 x 0.3 cm to 4.1 x 0.6 x 0.5 cm in greatest dimension.All identified lymph nodes are submitted. Summary of sections: BLN -- bisected lymph nodes LN1 -- lymph nodes LN2 -- largest lymph node, serially sectioned Page 3 of 6
+
+--- Page 4 ---
+SURGICAL PATHOLOGY REPORT 3. The specimen is received in formalin, labeled "left distal pelvic lymph node", and consists of portion of adipose tissue. The specimen is dissected to reveal multiple pink tan firm lymph nodes ranging from 0.5 x 0.3 x 0.3 cm to 4.2 x 0.6 x 0.5 cm in greatest. dimension.All identified lymph nodes are submitted. Summary of sections: BLN -- bisected lymph node LN1 -- one lymph node, serially sectioned LN2 -- largest lymph node, serially sectioned 4. The specimen is received fresh, labeled "bladder, prostate, seminal vesicles and perivesical lymph nodes". It consists of a  bladder and prostate measuring 18.4 cm from superior to inferior, 15.0 cm laterally, and 4.6 cm from anterior to posterior. The  bladder measures 5.5 x 3.5 x 3.2 cm, the prostate measure 3.2 x 3.6 x 3.0 cm, the right seminal vesicle measures 4.1 x 1.6 x 1.1 cm, the right vas deferens measures 3.1 cm in length and 0.3 cm in diameter, the left seminal vesicle measures 3.1 x 1.6 x 0.7 cm,  and the left vas deferens measures 4.7 cm in length and 0.3 cm in diameter. The anterior aspect of the bladder is inked black and the posterior blue. The right lobe of the prostate is inked green; the left is inked black. The prostatic urethral margin is shaved  and submitted. The bladder is opened along the anterior midline to reveal a tan firm tumor measuring 2.0 x 1.1 cm which is grossly situated within the posterior wali of the bladder. The lesion lies 1.2 cm from the left ureteral orifice and 1.1 cm from the right.  ureteral orifice. Both ureters are probe patent and measure up to 0.2 cm in maximum diameter. The lesion is sectioned to reveal  the tumor invading the bladder wall. Extension to the inked fat is grossly not identified. The remaining bladder mucosa is pink-red congested and focally hemorrhagic. No perivesical lymph nodes are identified. The prostate is serially sectioned to reveal pink  tan parenchyma. Representative sections are submitted including sections from each prostatic quadrant and transition zone. Tissue is submitted for Summary of sections: UTHM -- urethral margin RUM -- right ureter margin LUM -- left ureter margin L -- lesion  RUO -- right ureter orifice LUO -- left ureter orifice LP -- left posterior wall LA --  left anterior wall RP -- right posterior wall RA -- right anterior wall TRI -- trigone DOM -- dome F -- perivesical fat RSV -- right seminal vesicle LSV -- left seminal vesicle RAP -- right apex prostate LAP -- left apex prostate RAM -- right anterior mid prostate RPM -- right posterior mid prostate LAM -- left anterior mid prostate LPM -- left posterior mid prostate RAB -- right anterior base prostate RPB -- right posterior base prostate LAB -- left anterior base prostate LPB -- left posterior base prostate ADD -- additional sections of prostate 5. The specimen is received in formalin, labeled "left distal ureter large unclipped end margin", and consists of a 1.3 cm segment of ureter. The specimen is entirely submitted. Summary of sections: M -- margin U -- remainder of ureter  Page 4 of 6
+
+--- Page 5 ---
+SURGICAL PATHOLOGY REPORT 6. The specimen is received in formalin, labeled "right distal ureter large unclipped end margin", and consists of a 1.3 cm segment of ureter. The specimen is entirely submitted.. Summary of sections: M -- margin. U -- remainder of ureter Summary of Sections: Part 1:Urethral margin (fs) Block Sect. Site PCs 1 FSC 1 Part 2:Right distal pelvic lymph node. Block Sect. Site PCs 2 BLN 2 22 LN1 3 LN2 3 Part 3:Left distal pelvic lymph node. Block Sect. Site PCs BLN 1 2 1 LN1 2 2 LN2 3 Part 4:  Bladder, prostate, seminal vesicles and perivesicle lymph nodes; cystoprostatectomy Block Sect. Site PCs 7 ADD 7 1 DOM 2 F 2 5 L 7 1 LA 2 1 LAB 2 1 LAM 2 1 LAP 2 1 LP 2 1 LPB 2 1 LPM 2 LSV 2 1 LUM 1 2 1 LUO 2 RA 2 1 RAB 2 1 RAM 2 1 RAP 2 1 RP 2 1 RPB 2 1 RPM 2 1 RSV 2 1 RUM 2 1 RUO 22 1 TRI 1 UTHM 2 Page 5 of 6
+
+--- Page 6 ---
+SURGiCAL PATHOLOgy REPORT Part 5: Left distal ureter. Block Sect. Site PCs 11 M 22 U Part 6:  Right distal ureter Block  PCs Sect. Site 1 M 22 1 U Intraoperative Consultation: 1. Urethral margin (fs): Benign.. Permanent diagnosis: Same. Page 6 of 6 END OF REPORT
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diff --git a/output/text/9543fd41-1d60-46e9-92f6-eefc7c904664.txt b/output/text/9543fd41-1d60-46e9-92f6-eefc7c904664.txt
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index 0000000000000000000000000000000000000000..2600238fa0bbb029f9440a985f3ab2cd060ddf39
--- /dev/null
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+
+--- Page 1 ---
+The patient is a status-post AAA repair, status-post exploratory laparotorny # PRE OP DIAGNOSIS: Ischemic bowel. Post Op DiAgnoSIS: Sane. PROCEDURE: Exploralory laparotomy FINAL DIAGNOSIS: Collection Date Colon, total colectomy - INVASIVE WELL DIFFERENTIATED ADENOCARCINOMA OF (6.2 CM), ARISING IN A TUBULQVILLQUS.ADENOMA A InvaDing Into the musculaRis PRopRiA. B.  NO Angiolymphatic or Perineural. invasion noteD. C. SURGICAL MARGINS OF RESECTION FREE OF TUMOR. D. Twenty-five (25) pericolic Lymph nodes free of tumor. PATHOLOGICALSTAGE: T2,NO,MX.DUKE'S STAGE:A F. AsTLer-COller Stage 81. G. SMALL TUBULAR ADENOMAS. 1-DIffErentiateD AppenDiceal CArcinoiD (0.2 Cm} (see comment). COMMENT: The adenocarcinoma which is focally mucin producing, invades entire thickness of the muscle wall and abuts but does not invade adjacent subserosal fat  The incidental carcinoid of the vermiform appendix is tocated mostly in the sumucosa and does not shrow mitoses or necrosis.  SyNoPTic - PrImaRy COL On AND REcTAl TUmORS 4 Location: 1 1. Jleocecal Region 4. Descending Colon 2. Ascending Colon 5. Sigmoid Colon 3. Transverse Colon 6. Rectum B. Procedure: 2 Segmental Colectomy 3.Other Total Colectomy C. Size of Tumor (maximum dirnension): .Q cm D. Type: 2 1. Adenocarcinoma, Nos 9. Squamous Cell Carcinoma 2. Adenocarcinoma arising in a background. 10. Undifferentiated Carcinoma  of an adenoma. 11. Sarcoma 3. Adenocarcinoma arising in a background 12. Srnooth Muscle Tumor  of inflammatory bowel disease 13. Gastrointestinal strornal tumor 4. Adenosquamous carcinomia 14. Lymphoma 5.  Carcinoid Tumor (Neuroendocrine Tumor)15. Other 6. Mucinous Adenocarcinoma 7. Signet ring cell type Adenocarcinoma 8. Neuroendocrine Carcinoma E. Grade: 2 1. Well differentiated 2. Moderately differentiated 3.Poorly differentiated Extent of Infiltration: 3 1. Lirnited to the mucosa 4.Infiltrating through muscularis propria into serosal 2. Into subrnucosa adipose tissue 3.  Involving muscularis propria 5. Involving adjacent organs/ pelvic walil G Angiolymphatic Invasion: 2 1.Yes 2. No H. Surgicat Margins Invoived: 2 Yes 2. No Regional Lymph Node Involvement: 2 "Yes 2. No If regional lymph nodes involved. Number positive/number examined: Q/25 K Extracapsular spread : 2 Yes 2.No. I. Associated conditions. N/A 1. Ulcerative colitis. 2.Crohns Disease. 3. History/ presence of adenomatous polyps. 4. Multiple polyposis syndromes. 5. Divericulosis. M. TNM Stage: T2NQMX N Dukes' Stage: 1 1. A (limited to rnucosa and musculans) 2. 6.(through muscularis into subserosa) 3. C (through subserosa and involving adjacent organ/pelvic wall/regional or distant lymph nodes) Astler - Coller Stage: 2 1. A (rmucosa but not into muscularis propria) 2 B1 (muscularis propria but not through, LN negative). 3. B2 (through muscularis propria into subserosal fibroadipose tissue, LN negative)  4. C1 (limited to muscularis propria but not through serosa, LN positive) 5. C2 (invades serosal adipose tissue, LN positive)
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diff --git a/output/text/956fc257-5e21-4df2-a121-34b51a3b4bbd.txt b/output/text/956fc257-5e21-4df2-a121-34b51a3b4bbd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0aa6e840e5c08d669f6f480d05d351917a6ebbd7
--- /dev/null
+++ b/output/text/956fc257-5e21-4df2-a121-34b51a3b4bbd.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UUID:D7967904-FE4B-4BB5-9282-5354404AC939 TCGA-CC-A8HS-01A-PR Redacted Clinical Case Report (For Collection of Cancerous Tissue) IGD03 Creirort, heyaticllulgr NCS 8/7 Sit: sluier C220 QJ 1/2g/_3 Informed Consent I personally informed this patient that a snecimen(s) would be collected to be used for research purposes. I reviewed the - with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator. Signature Date Clinical Information GENERAL INFORMATION Date of Birth (mm/dd/ww) Height Marital Statusd Race Temperature Gender Weight Blood Pressure Heart Rate Male  Femaie HISTORY OF PRESENT ILLNESS Chief Complaints: Abdoom`nal >cu'n | bloatiney ) feve- Clinical Findings: Performance Scale (Karnofsky Score):.  100 Asymptomatic  80-90 Symptomatic but Fully Ambulatory   60-70 Symptomatic, in bed less than 50% of day  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden ..  20-30 Bed Ridden CURRENT MEDICATIONS Drug Dose  Route Frequency Date (mm/dd/yyy) 1 To 1 To / To To To
+
+--- Page 2 ---
+PAST MEDICAL HISTORY Diagnosis/Disease/Disorder/Iniury  Diagnosis Date Treatment Status OB/GYN HISTORY Menopausal Status Date of First Menses # of Pregnancies  Pre-menopausal  Peri-Menopausal Date of Last Menses # of Live Births  Post-menopausal Birth Control:  Condomd  Oral Contraceptive  IUD  Hormone Replacementd  Other: Therapy: SOCIAL HISTORY Occupation: Environmental Hazards: Smoking History Current Status TYPE Packs/day Duration When Quit  YES 2$NO (yrs) (yr). Alcohol Consumption Current Status TYPE Drinks/day Duration When Quit FyES  ANO (yrs) (yr) Drug Use Current Status TYPE Freguency Duration When Quit  YES 9NO (yrs) yr) FAMILY MEDICAL HISTORY Relative  Dlagnosis Age of Diagnosis LAB DATA Test Result Date Test Result Date HIV  Negative  Positive: CEA   Negative  Positive: Hep B Negative  Positive: CA 15-3   Negative  Positive: Hep C Negative  Positive: CA 19-9  Negative  Positive: AFP   Negative  Positive: PSA   Negative  Positive: Other: Other: Negative  Positive:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+DIAGNOSTIC STUDIES Study Results Date Ultrasound X-Ray CT Ativmowy Was fownd in te live x Endoscopy MRI Biopsy CLINICAL DIAGNOSIS Preoperative Clinical Diagnosis Jaes. Cauces Location of Suspected Involved Lymph Nodes Location of Suspected Distant Metastasis Clinical Staging Date of Diagnosis T3 NJ M O Stage: TI c Treatment Information SURGICAL TREATMENT Procedure Date of Prnred LeSector the soht M Primary Tumor Organ Detailed Location Size Liuck.ZuneR Rioht licR 6xS x5 cm Extension of Tumor Lymph Nodes Description Location of Lymph Nodes # of Lymph Nodes  Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes. Distant Metastasisd Organ Detailed Location Size. Surgical Staging T 3. Ns. Ma Stage:TL NEOADJUVENT THERAPY (Chemo, Radiation, Immuno, Hormonal, or Molecular) Drug/Treatment Dose Route Frequency Date (mm/dd/yyyy) To 1 To / 1 To / To / / To 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by: ---- Date: - Time: Preserved by:- Date: Time: SPECIMEN TYPE (# of samples provided) Frozen Paraffin Block Blood/Serum/Plasma Slide Diseased Normal Diseased Normal Diseased Diseased Normal Normal 2 A 2 4 2.  Time to LN2 Time to Formalin Time to LN2 min min min PATHOLOGICAL DESCRIPTION Primary Tumor Organ Size Extension of Tumor Distance to NAT TeimeR 6 xSxS /peR 6 Liger. cm RF cm Lymph Nodes Location # Examined # Metastasized Distant Metastasis Organ Detailed Location Size Pathological Staging M o Stage: E pT z N Notes: po8i1 3, Ncgative O
+
+--- Page 5 ---
+Consolidated Pathology Diagnosis Cell Distribution + Structural Pattern  Diffuse  Streaming Mosaic x  Storiform Necrosis Fibrosis  Lymphocytic Infiltration Pallsading Vascular Invasion K Cstic Degeneration Clusterized Y Bleeding  Alveolar Formation  Myxoid Change  Indian File Psammoma/Cakcification Squamous +- Adenomatous +  Sarcomatous + Lymphomatous + Squamold Cell Glandular cell N  Round Cell  Large Cell Spindle Cell Cell Stratficatlon Fibroblast Srmall Cell Keratin Secretion Osteoblast RS Cell/RS Like  Desmosome Intracyt. Vacuole ly Lipoblast Inflam. Cell Peari  Gland formation zMyoblast  Plasma Cell Cellular Differentiation:  Well  Moderate  Poor Nuclear Atypia: 0 I II III Aniso Nudeosis x. Hyperchromatism  Nucieolar Prominent Y Multinucleated Giant Cell Y. Mitotic Activity Nuclear Grade: Final Pathology Report Histological Diagnosis: tlat oce/l (ak C RC > /sroGrade: Comments: D19t7 Drqy D;407 D498 M,- lr -- laieyoa retress?es to Date b u/8/13 INTEGRATED REPORT OF FINDINGS BY COLLABORATORS AND PATHOLOGISTSignoss Uscree ng riteria Frimoy Tumcr Si bisc:enan t.PAA Dicrepancy Prur Maignncy History seisci VALIFIEES SQUAF
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diff --git a/output/text/959cba98-1958-4264-97d8-d754c60b48a7.txt b/output/text/959cba98-1958-4264-97d8-d754c60b48a7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..761919e8ebd7eeda2a88cddbfa2b59c2348cc6fc
--- /dev/null
+++ b/output/text/959cba98-1958-4264-97d8-d754c60b48a7.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Right hemicolectomy specimen with an ulcerated cecum carcinoma conforming to the histological type of a moderately differentiated colorectal adenocarcinoma, affecting Bauhin's valve and with a greatest diameter of 4.5 cm. Invasive spread of tumor within all layers of the intestinal wall and as far as the neighboring mesocolic fatty tissue and the subserosa. Remainder of colon mucosal membrane with a hyperplastic polyp. Appendix with apparent post-inflammatory fibrosis of the wall. Oral and aboral resection margins and large omentum tumor-free. Fifteen mesocolic and mesenteric lymph nodes tumor-free with uncharacteristic reactive changes. Tumor stage thus pT3 pN0 (0/15) L0, V0; G2
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diff --git a/output/text/959d823d-6a06-4624-b148-47153136cfb3.txt b/output/text/959d823d-6a06-4624-b148-47153136cfb3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..397573d2f1280e6439d1e9d98d0abe1ed6185a1f
--- /dev/null
+++ b/output/text/959d823d-6a06-4624-b148-47153136cfb3.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+DIAGNOSIS: Left kidney, radical nephrectomy:. Infiltrating renal carcinoma. Tumor Characteristics: .Histologic type: .Papillary (chromophil) renal cell carcinoma, oncocylic variant, with extensive degenerative changes and necrosis. 3.  Macroscopic extent of tumor: Tumor involves perinephric adipose tissue.. 4. Nuclear grade: Fuhrman grade: 2/4. 5. Lymphovascular space invasion: Not identified.. 6. Transcapsular invasion: Tumor focally infiltrates through renal capsule to involve perinephritic adipose tissue. Renal vein invasion: Not Identified. 8. Venacaval invasion: Not resected. 9. Adrenal gland: Not identified. Surgical Margin Status: Soft tissue margins: Negative for tumor.. 2. Ureteral margin: Negative for tumor. Vascular Margins: Negative for tumor.. Lymph Node Status: No lymph nodes identified. Other Significant Findings:. 1.pTNM stage: T3a NX MX, stage III. Staging Sheet
+
+--- Page 2 ---
+HARRACLINOALINFORMATIONROOOCRAE CLINICAL HISTORY: Preoperative Diagnosis: Left renal mass Postoperative Diagnosis: Symptoms/Radiologic Findings:. SPECIMENS: Left kidney PRNSPECIMENPATARMERONMNRAOORTKSOM GROSS DESCRIPTION:A Received in formalin labeted t. and #1 is a nephrectomy specimen, consisting of a 10.5 x 5.8 x 3.1 cm kidney, with a moderate amount of attached perinephric fat. The specimen has been previously bivalved. There Is a minimal amount of identifiable ureter and a minimal amount. of possible renal vein and artery. The capsule is smooth and tan. The cut surface consists of a 5.2 x 4.5 x 4.1 cm focally cystic tan red to orange mass,. which diffusely involves the adipose tissue, and abuts the inked perinephric fat. The adipose tissue adjacent to the mass has a glistening yellow appearance. The remainder of the cut surface consists of tan pink parenchyma, with a 0.4 cm tan brown cyst. The cortical medullary junction is ill. defined. The urothelium is gray white. No enlarged lymph nodes are identified. The adrenal gland is not present. The specimen is inked, serially sectioned, and representative sections are submitted as labeled: 1-ureterovascular margins; 2 to 4--mass to inked perinephric fat; 5-mass; 6-mass to. uninvolved parenchyma: 7--atistening yellow adipose tissue adjacent to mass; 8--uninvolved parenchyma to include cyst; g--uninvolved parenchyma.. The blg  dso received in the same container are two orange cassettes labeled A and C and a green and yellow cassette labeled pr genomic research study..
\ No newline at end of file
diff --git a/output/text/95ba0dbf-b824-4d77-afdb-157f4481fcc0.txt b/output/text/95ba0dbf-b824-4d77-afdb-157f4481fcc0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..88a65d8feb6a5301c064003e93ff364d35bd8b72
--- /dev/null
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+
+--- Page 1 ---
+Carunomu,mfilmrotiny ductiL sA 1abulu 8522/3 Sit lni  bUsst,Nos. Cso. Patient: -urgical Pathology Surg Path CLINICAL HISTORY: year old woman with a large right breast cancer. GROSS EXAMINATION:S A. "Large~right breast cancer". Received fresh is right modified radical mastectomy, 630 grams, and 25 x 16.5 x 3.6 cm. The overlying skin ellipse measures 15.3 x 10.6 cm. The areolar is 6.8 cm in diameter, and the nipple, 1.5 cm. Serial sectioning reveals extensive involvement of the breast tissue by a large, white/light yellow tumor 12 x 9.5 x 4 cm, which grows in an. infiltrative fashion and demonstrates focal calcification. It is located approximately 0.5 cm from the closest superior margin, 1.5 cm from the inferior margin, 0.1 cm from the deepest margin, 1.5 cm from the medial. margin, and 3 cm from the axillary appendage.  Focal hemorrhage is present in the subcutaneous portion of the breast. Dissection through the axillary appendage demonstrates multiple enlarged lymph nodes up to 2.4 cm in size. portion of the fresh tumor tissue is submitted for ER/pR studies and for. A tissue bank. The representative sections of the specimen are submitted.. BLOCK SUMMARY: A1-A2- tumor and the closest deep margin. A3- upper inner quadrant. A4- upper outer quadrant. A5- lower inner quadrant. A6- lower outer quadrant. A7- skin and underlying hemorrhage. A8- nipple. A9-Al0- level 1 lymph node candidates. A11- A12-. level 2 lymph node candidates. A13-A14- level 3 lymph node candidates. DIAGNOSIS: A. "RIGHT BREAST (MODIFIED RADICAL MASTECTOMY) ": INFILTRATING. CARCINOMA PRESENT. HISTOLOGIC TYPE DUCTAL WITH PROMINENT LOBULAR COMPONENT.S N.S.A.B.P. HISTOLOGIC GRADE, 3 OF 3. N.S.A.B.P. NUCLEAR GRADE, 2 OF 3. UUID:FF5D000A-4600-4C42-8802-4BCD29F61CA6 Redacted TCGA-B6-A0RV-01A-PR SIZE OF INVASIVE COMPONENT, 12 X 9.5 X 4 CM. THE TUMOR IS PRESENT IN ALL QUADRANTS OF THE BREAST. IN-SITU CARCINOMA, PRESENT. OCCUPYING 5% OF THE TUMOR. TYPE OF IN-SITU CARCINOMA, LOBULAR. EXTENSIVE INTRADUCTAL COMPONENT, ABSENT. MULTIFOCAL TUMOR IS PRESENT. STATUS OF NON-NEOPLASTIC BREAST TISSUE: FIBROCYSTIC CHANGE INCLUDING INTRADUCTAL HYPERPLASIA, DUCTAL ECTASIA, AND APOCRINE METAPLASIA. LYMPHATIC/VASCULAR INVASION IS PRESENT (BLOCK A5). SURGICAL MARGIN IS NEGATIVE FOR CARCINOMA. NIPPLE STATUS: PAGET'S DISEASE ABSENT. SKIN STATUS: UNINVOLVED BY CARCINOMA. MUSCLE STAUS; UNINVOLVED BY CARCINOMA. METASTATIC CARCINOMA PRESENT IN FIVE OF TEN LYMPH NODES.S THE LARGEST INVOLVED LYMPH NODE IS 2.4 CM. EXTRACAPSULAR EXTENSION IS PRESENT. Cage is circe MICROCALCIFICATIONS ARE PRESENT, IN ASSOCIATION WITH CARCINOMA. ESTROGEN/PROGESTERONE AND CELL CYCLE ANALYSIS PENDING.S METHODOLOGY, FRESH TISSUE. I of 2
+
+--- Page 2 ---
+RESULTS WILL BE ISSUED IN AN ADDENDUM. Verified by: ADDENDUM 1: Tissue was sent to for assay of the Estrogen. and Progesterone receptors. The Estrogen receptor was judged as positive with For complete details. Verified by:. 2 of 2
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diff --git a/output/text/961d08bb-6aac-412a-a935-cadd564f6a30.txt b/output/text/961d08bb-6aac-412a-a935-cadd564f6a30.txt
new file mode 100644
index 0000000000000000000000000000000000000000..036b5167bc723ec713d039c5622da442b4f2f6fa
--- /dev/null
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+
+--- Page 1 ---
+UUID:5DFA7970-3F68-4FC3-828A-5A42E866ECC3 NLY - PERSONAL DATA - PRIVACY ACT OF 1974 TCGA-A2-A0D1-01A-PR Redacted SURGICAL PATHOLOGY REPORT Patient: FMP/SSN: DOB/Age/Sex: Specimen #: Location: F Race: wHITE Taken: Physician(s) : Received: Reported: * * AMENDED* * 1cs-0-3 SPECIMEN: Carcin om, infi1tntng dinto, Nt. A: SENTINEL NODE #1 B: ADDITIONAL LYMPH NODE C: SENTINEL LYMPH NODE #2 D: LEFT BREAST LUMPECTOMY 8500/3 E: FIBROUS TISSUE AT SUP-LAT MARGIN Sit: brast Nos C5o.9 FINAL DIAGNOSIS: Js5/n ls A. LYMPH NODE, SENTINEL #1, EXCISION: - TWO BENIGN LYMPH NODES, NO MALIGNANCY IDENTIFIED.S B. LYMPH NODE, "ADDITIONAL, " EXCISION: - NO LYMPH NODE IDENTIFIED. FIBROADIPOSE TISSUE ONLY. C. LYMPH NODE, SENTINEL #2, EXCISION:  ONE BENIGN LYMPH NODE, NO MALIGNANCY IDENTIFIED. D. BREAST, LEFT, LUMPECTOMY: TUMOR TYPE: INFILTRATATING DUCTAL CARCINOMA WITH NEUROENDOCRINE FEATURES. NOTTINGHAM GRADE: POORLY DIFFERENTIATED (G3). NOTTINGHAM SCORE: 8/9 (Tubules= 3, Nuclei= 3, Mitoses- 2; mitotic count 8 per 10 Hpr at 20x power-0.50 field diameter) TUMOR SIZE (GREATEST DIMENSION) : 3.0 CM (meaSured grOSsly) TUMOR NECROSIS: ABSENT. MICROCALCIFICATIONS: ABSENT. VENOUS / LYMPHATIC INVASION: NOT IDENTIFIED. MARGINS : -DISTANCE OF INVASIVE TUMOR FROM NEAREST MARGIN IS O.5 CM, FROM INFERIOR MARGIN. INTRADUCTAL COMPONENT: DUCTAL CARCINOMA IN SITU, SOLID TYPE, LOW NUCLEAR GRADE. LYMPH NODES: THREE NEGATIVE FOR TUMOR (see speCimens A and C) MULTICENTRICITY: NOT IDENTIFIED. ESTROGEN RECEPTORS: NEGATIVE. (see speCimen) PROGESTERONE RECEPTORS: NEGATIVE. (see speCimen HER 2 NEU by IHC: POsITIVE. (see specimen Page 1 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 Continued on Next Page
+
+--- Page 2 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: FINAL DIAGNOSIS (continued) : PATHOLOGIC STAGE: pT2 NO Mx ADDITIONAL PATHOLOGIC CHANGES: BENIGN INTRADUCTAL PAPILLOMA. E. SOFT TISSUE, "FIBROUSE TISSUE AT SUPERIOR-LATERAL MARGIN, " EXCISION:  BENIGN BREAST TISSUE, NO MALIGNANCY IDENTIIFIED. *  Report Electronically Signed Out ** CLINICAL DIAGNOSIS AND HISTORY: -year-old female with diagnosis of left breast cancer. GROSS DESCRIPTION: A. Received fresh, labeled with the patient's name, designated "sENTINEL NODE #1" is a 3.0 x 1.5 x 0.5 cm irregular portion of soft tissue. Sectioning reveals a 1.0 x 1.0 x 0.5 cm pink-tan lymph node. The lymph node is bisected. One half of the lymph node is submitted in OcT for cbcp protocol, and the remainder is submitted for permanent. 2C2 B. Received in formalin, labeled with the patient's name, , designated "ADDITIONAL LyMPH NODE" is a single, tan-brown fragment of soft tissue measuring 1.0 cm in greatest dimension. specimen is submitted in its entirety in one cassette. 1C1 The r Recsivr! in formalin, labeled with the patient's name,. ; designated "SENTINEL LYMPH NODE #2" is a lobulated fragment of yeliow, adipose tissue measuring 1.5 x 2.0 x 0.3 cm. The specimen is bisected to reveal one lymph node measuring 0.7 cm in greatest dimension. The specimen is submitted entirely in one cassette. 1C2.. D. Received fresh, labeled with the patient's name, designated "LEFT BREAsr LUMPECTOMy" is a globoid portion of soft tissue oriented with the short stitch superior and long stitch lateral. The. specimen measures 9.0 cm medial to lateral, 7.5 cm anterior to posterior, and 4.0 cm superior to inferior. The lightly pigmented superficial skin ellipse measures 6.5 x 1.0 cm and is otherwise unremarkable. The specimen is inked as follows: superior = gold, inferior = green, medial - red, lateral = yellow, anterior = orange, and posterior = black. Serial Page 2 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 Continued on Next Page
+
+--- Page 3 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION (continued) : sections reveal a firm, very well circumscribed, centrally located pink-white mass measuring 3.0 x 2.6 x 2.2 cm. The mass 'approaches the margins as follows: superior and inferior 0.7 cm, posterior 0.8 cm, and medial 1.4 cm. The remainder of the cut surface is composed of lobulated, yellow-tan, adipose tissue admixed with a moderate amount of tan-white, fibrous tissue. No additional lesions are identified. sections are submitted as follows: Representative Cassette Summary: D1-D2: Mass. D3: Adjacent normal.. D4-D5: Additional mass. D6-D7: Adjacent to mass. D8: Additional mass, same section as D4. D9: Skin. D10: Additional firm, fibrous tissue. 10CF The specimen was placed in formalin at formalin for a total of approximately 28 hours. The specimen will be in. E. Received in formalin, labeled with the patient's name, designated "FIBROUS TISSUE AT SUPERIOR-LATERAL MARGIN" is a fragment of yellow-white, fibrous tissue and adipose tissue measuring 3.7 x 2.0 x 0.8 cm. Representative sections are submitted entirely in three cassettes. 3 C3 Page 3 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 End of Report.
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diff --git a/output/text/9631d2cf-6c43-49c3-b9c6-e693f810b520.txt b/output/text/9631d2cf-6c43-49c3-b9c6-e693f810b520.txt
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index 0000000000000000000000000000000000000000..dcbc6590eeb21a332476217dd30708ac57bc6d9c
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+
+--- Page 1 ---
+Cavc inoma; renalcull, chromphobe type 831713 Site:  Kidney NOS Cb4.9 18f4/12 J Mrn: UUID:97F17D1B-SEBF-4940-88D5-8ADF8E71ECCF TCGA-NP-A5B3-01A-PR Age: Sex: Redacted DOB: Surgical Pathology Histopathological Examination Path#: Pre-Op Diagnosis Right Renal Mass Order Physician Specimens Kidney, right for Frozen Diagnosis : Report  GROSS EXAMINATION: : The specimen is received fresh labeled with the name of the patient and labeled as kidney, right..  The specimen consists measures 11.5 x 6 x 4.5 cm and weighs 201 grams. The ureter and vascular margins are submitted in block 1.  The renal sinus/hilar margin is submitted in block 2. Sectioning into the kidney shows two masses.  The first is in the mid-posterior aspect.. This mass is brown and measures 3.8. cm in greatest dimension. It bulges against the capsule, but the capsule strips with ease from over the mass.. Sections of the capsule overlying the mass are submitted in block 3.  The mass does not grossly involve the renal. sinus. A section of the mass and renal sinus is submitted in block 4.  Additional sections of the mass are submitted. in blocks 5-8. The second mass is in the mid-lateral aspect. of the kidney and is 0.6 cm away from the first mass,. measuring 1.0 x 0.8 x 0.8 cm. capsule, but the capsule strips with ease. Sections of the capsule overlying the mass are submitted in block 9. The capsule does not grossly involve the renal sinus.  A section of~the two masses and intervening normal-appearing tissue is submitted in block 10. Sections'of the second mass are. submitted in blocks 1l-13.  The pelves and calices are not. grossly dilated. The cortex averages 0.8 cm.. section of kidney is submitted in block 14. The attached A random fat is dissected, and no lymph nodes or adrenal tissue are identified. DIAGNOSIS BASED ON GROSS AND MICROSCOPIC EXAMINATION: Kidney, right nephrectomy: THIS CONFIDENTIAL AND PRIVILEGED DOCUMENT/INFORMATION IS PROTECTED BY FEDERAL AND STATE LAW.  UNAUTHORIZED DISCLOSURE, DISSEMINATION OR DUPLICATION IS PROHIBITED Path #: Page 1 of 2 Visit #:
+
+--- Page 2 ---
+- Chromophobe renal cell carcinoma, two foci, 3.8 and 1.0 cm, see cancer case summary checklist. Tumor limited to kidney. Margins free of tumor. [T-71000 M-82703 189.0 P3-44070] KIDNEY: Nephrectomy, Partial or Radical PROcEDURE: Radial nephrectomy. SPECIMEN LATERALITY:* Right. TUMOR SITE: Middle. TUMOR SIZE: 3.8 cm, 1.0 cm TUMOR FOCALITY: Multifocal. Tumor limited to kidney. MACROSCOPIC EXTENT OF TUMOR: HIsToLogic TypE: Chromophobe renal cell carcinoma. SARCOMATOID FEATURES: Not identified. TUMOR NEcROsIS: Not identified. HISTOLOGIC GRADE (FUHRMAN NUCLEAR GRADE): G2, nuClei slightly irregular approximately 15 mm (nucleoli evident). MICROSCOPIC TUMOR EXTENSION: Tumor limited to kidney. MARGINS:  Uninvolved by invasive carcinoma. LYMPH-VASCULAR INVASION: Not identified. PATHOLOGIC STAGING (pTNM): TNm Descriptors:  N/A Primary Tumor (pT): pTla: Tumor 4 cm or less in greatest. dimension, limited to kidney. 'pnx: Cannot be assessed. Regional Lymph Nodes (pN):  Distant Metastasis (pM): N/A PATHOLOGIC FINDINGS IN NONNEOPLASTIC KIDNEY: None identified. COMMENT : The case has been delayed for iemmunohistochemical studies have been performed. as the differential would include an oncocytoma versus chromophobe renal cell carcinoma versus granular variant of clear cell type renal cell carcinoma.Stains support the diagnosis (Positive stains: Cytokeratin 7, EMA, CDll7, E-Cadherin, CDl0; Negative. stains: Vimintin, Cytokeratin 20). Control slides were reviewed and found appropriate. SUMMARY OF PATHOLOGIC STAGING: pTlaNX Intradepartmental consultation obtained. M24 rteri THIS CONFIDENTIAL AND PRIVILEGED DOCUMENT/INFORMATION IS PROTECTED BY UNAUTHORIZED DISCLOSURE,  DISSEMINATION FEDERAL AND STATE LAW. OR DUPLICATION IS PROHIBITED Page 2 of 2 Path #: Visit #:
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diff --git a/output/text/9633f0a4-66ad-4e55-9469-68550d1018f7.txt b/output/text/9633f0a4-66ad-4e55-9469-68550d1018f7.txt
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index 0000000000000000000000000000000000000000..d382934517155ab0c7abf56e3ad6f94a55464a1d
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+
+--- Page 1 ---
+UUID:2729C641-D25B-4C92-94C8-0BC4C7CE74DE TCGA-E1-A7Z2-01A-PR Redacted Patient: Surgical Pathology: Additional Info - Surg Path CLINICAL HISTORY: Brain neoplasm left frontoparietal, left facial seizures. HIsrory oF pREsENT ILLNESS: : comes to clinic today. . She had a sensory seizure. She had a second sensory seizure. She had two MRI scans that showed a growing lesion in the left frontal area. She is right-handed. GROSS EXAMINATION: "Brain tissue (AF1)", received fresh for frozen section placed in formalin at is a 0.8 x 0.5 x 0.4 cm aggregate of multiple fragments. of sott tan tissue. Representative is frozen as AFl, frozen remnant in Al. Additional sections are submitted in A2, with a small fragment retained in formalin. B. "Brain tissue", received fresh placed in formalin at Q is a 1.5 x 1 x 0.5 cm aggregate of multiple fragments of soft tan tissue, submitted in B1 and 2. Smali fragments are retained in formalin. INTRA OPERATIVE CONSULTATION: A. "Brain tissue": AFl (representative)-glioma, low grade (Dr.. MICROSCOPIC EXAMINATION: Microscopic examination shows brain infiltrated by a glial neoplasm characterized by cells with round nuclei and delicate chromatin. Satellitosis and minigemistocytes are seen. Mitoses are rare. Endothelial proliferation and necrosis are not seen.  The tumor cells are immunopositive for Grap.  HAM56 highlights blood vessels. The Mib-1 index is approximately 15%. IMMUNOHISTOCHEMICAL FINDINGS: The immunoperoxidase tests reported herein were developed and their performance characteristics were determined by the Some of them may not be cleared or approved by the U.s. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of i988 (cLiA) as qualified to perform high complexity clinical testing. I-03 DIAGNOSIS: Y3win, RiynatertorisV NoS C 71.O Dete A. BRAIN TISSUE; EXCISION: OLIGODENDROGLIOMA (WHO GRADE II). MJ s/8Ji4 B. BRAIN TISSUE; EXCISION: OLIGODENDROGLIOMA (WHO GRADE II), WITH ELEVATED MIB-1 INDEX.S SEE COMMENT. cOMmEnr: The Mib-1 index is approximately 15% and is worrisome. 1p/l9q testing will be performed. Clinical follow-up is indicated. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es). 1 of 5
+
+--- Page 2 ---
+Electronically signed: ADDENDUM 1: TISSUE TYPE: BRAIN TISSUE CONTAINING OLIGODENDROGLIOMA WITH ELEVATED MIB-1 INDEX (WHO GRADE II;) FISH INTERPRETATION SUMMARY: FISH MARKER INTERPRETATION % OF TUMOR CELLS FINDINGS/STATUSS EXHIBITING ABNORMALITY EGFR (7p12) ABNORMAL 93% GAIN MET(7q31) NOT ORDERED 7 CEP ABNORMAL 89% GAIN PTEN(10q23) ABNORMAL 82% LOSS 10 CEP ABNORMAL 81% LOSS 1p36 NORMAL INTACT 1q25 REFERENCE PROBE IS INTACT 1p32  NORMAL INTACT 1qtel REFERENCE PROBE IS INTACT  NORMAL 19q13 INTACT 19p13 REFERENCE PROBE IS INTACT BRAF(7q34)  NORMAL INTACT KIAA1549 NORMAL INTACT INTERPRETATION SUMMARY: EGFR,7 CEP, PTEN, AND 1O CEP: 4 OF 4 ABNORMAL MARKERS.S BRAF:KIAA1549 GENE FUSION/REARRANGEMENT IS NOT EVIDENT. THERE WAS NO EVIDENCE FOR DELETION OF EITHER CHROMOSOME 1p OR 19q. COMMENT: SEQUENCING FOR P53 MUTATIONS WILL BE ORDERED REFLEXIVELY AND REPORTED AS AN ADDENDUM. Please see Image Cytometry Report  for results of supplementary tests. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es).. . M.D. Electronically signed: ADDENDUM 2: 358 IHC Antibody: Interpretation Score % of Tumor Cells of. ACIS III IHC (0-3+) Exhibiting Staining SCORE CD/45-LCA 15% Ki-67 HIGH 15% IN SURG PATH MGMT 10% NEGATIVE 11% EGFR WT NOT PERFORMED EGFR VIII NOT PERFORMED PTEN NOT PERFORMED Printed by: 2 of 5
+
+--- Page 3 ---
+I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es).. M.D. Electronically signed: ADDENDUM 4: Test Performed: TP53 GENE SEQUENCING Interpretation: EXTRACTED DNA,  FROM UNSTAINED SLIDES, (TP53 SEQUENCING FOR LI-FRAUMENI SYNDROME AND SOMATIC MUTATIONS) :S NEGATIVE. TP53 MUTATIONS NOT DETECTED. SEE OBJECTIVE FINDINGS AND COMMENT. Comment: Mutations in Tp53 are rarely found in gliomas with 1p/19q loss of. heterozygosity. TP53 mutations are more often found in astrocytic tumors and correlate with a worse prognosis. Additional information can be found in McLendon et al. Cancer. 2005; 104:1693-9 and references within. Clinicians should correlate these results with clinical and other laboratory findings. The sensitivity of DNA sequencing is 99% for the detection of nucleotide base. changes, small deletions, and insertions in the regions analyzed. However, this assay may not detect an acquired mutation which is present below the 25%. detection limit (i.e., mutant cell population of < 25%). Only the coding regions of the TP53 gene and immediate flanking intronic sequences were examined. Changes in the promoter region, farther into the introns, or in. other non-coding regions of the gene would not be detected. Mutations in genes other than Tp53 would not be identified. Large deletions, duplications, multiple exon insertions, sequence alterations adversely affecting primer binding, and complete deletion of one allele may not be identified using these methods. For additional information or for help interpreting the results of this test, please contact the REFER TO FOR COMPLETE REPORT AND METHODOLOGY. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es).. M.D. Electronically signed: ADDENDUM 5: Please see MOLECULAR DIAGNOSTICS Reporti for complete report. Testing was performed on sample IDH1 MUTATION TESTING WITH REFLEX TO IDH2 INTERPRETATION: NEGATIVE. IDH1 AND IDH2 MUTATIONS NOT DETECTED. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es). i.D. Electronically signed:  Printed b! 4 of 5
+
+--- Page 4 ---
+Performed by: SURGICAL PATHOLOGY Ordering MD: 1083 5 of 5
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diff --git a/output/text/964fbe7a-d770-4ccf-a497-ec3506ce0185.txt b/output/text/964fbe7a-d770-4ccf-a497-ec3506ce0185.txt
new file mode 100644
index 0000000000000000000000000000000000000000..80fb2ce95ce5327ddf74f1345edc12fc7596b350
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+FINAL DIAGNOSIS: PARTS 1 AND 2: COLOn, SIGmOID AnD RECtuM, RE$EctION - A.  InVasiVe WELl tO mODeRateLy DIffEReNTiaTeD ADenOcArciNOmA, meAsuRInG 5.5 Cm IN GrEATESt DImeNSiOn, iNVADiNG THrOugh muScULArIS PrOpRIA InTO PERICOLONIC ADipOSe TISSUE (EXTENDING TO WITHIN LESS THAN 1 MM TO SEROSAL SURFACE). B. NO DEFINITE PERINEURAL INVASION IS SEEN. C.  PROXIMAL AND DISTAL SURGICAL RESECTION MARGINS NEGATIVE FOR TUMOR. D.  MULTIPLE REGIONAL LYMPH NODES POSITIVE FOR METASTATIC ADENOCARCINOMA (3/14). E. Pathologic stage: pt3, n1, Mx. MICROSCOPIC: ICGA-AZ-4308  SyNOPTIC DATA - PRIMARy COLON AND RECTAL TUmORS SPECImEN TyPE: Sigmoidectomy SPECIMEN LENGTH: 11.5 cm TUMOR SITE: Sigmoid colon TUMOR CONFIGURATION: Infiltrative TUMOR SIZE: Greatest dimension: 5.5 cm Additional dimensions: 4.5 cm iNTActNESS OF meSOrecTum: Not applicable HistOLOgIc TyPE: Adenocarcinoma HISTOLOGIC GRADE: Low-grade (well to moderately differentiated) PATHOLOGIC STAGING (pTNM): pT3c/d pN1 Number of nodes examined: 14 Number of nodes involved: 3 pMX MARGINS Proximal margin uninvolved by invasive carcinoma Distal margin uninvolved by invasive carcinoma Circumferential (radial) margin - Not applicable Mesenteric margin uninvolved by invasive carcinoma ANGIOLYMPHATIC INVASION: Present PERINEURAL INVASION: Absent TUMOR BORDER CONFIGURATION: Infiltrating TUmORAL LyMPHOCyTIC RESPONSE: Mild to moderate ADDITIONAL PATHOLOGIC FINDINGS: None identified
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diff --git a/output/text/96544559-e2b6-4527-8a6a-5d71bf3f00cb.txt b/output/text/96544559-e2b6-4527-8a6a-5d71bf3f00cb.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9d1e90a8ae6ad03c6ba2a8e14ac311de876de620
--- /dev/null
+++ b/output/text/96544559-e2b6-4527-8a6a-5d71bf3f00cb.txt
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+
+--- Page 1 ---
+*** Diagnosis / Diagnoses: *** Right hemicolectomy specimen with an ulcerated colon carcinoma conforming to the histological type of a moderately differentiated, partially mucus-producing, colorectal adenocarcinoma, located 3.5 cm aborally from  and almost circularly occupying the intestinal wall over a length of 4 cm. Invasive tumor spread within all layers of the intestinal wall and extending into the neighboring mesocolic fatty tissue Appendix with apparent post-inflammatory fibrosis of the wall. Oral and aboral resection margins and large omentum tumor-free. Seven of twenty-six lymph nodes with metastases from the colon carcinoma that are restricted to the lymph nodes. Remaining lymph nodes with uncharacteristic reactive changes. Tumor stage thus: pT3 pN2 (7/26), L0, V0; G2. Based on histological findings sent for information purposes (Examination no. not clearly legible, findings of. dermatopathological test laboratory,  there is a skin metastasis from an adenocarcinoma in a location that is not indicated. Based on the negative CK-20 results for the tumor cells, this is apparently not a skin metastasis from a colorectal carcinoma, but a skin metastasis from a primary tumor located elsewhere.n.
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diff --git a/output/text/966ab742-0a0f-4922-8511-efe5af39625e.txt b/output/text/966ab742-0a0f-4922-8511-efe5af39625e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9cd6a9e9d0f5062796b688f3768af85cecff7ae6
--- /dev/null
+++ b/output/text/966ab742-0a0f-4922-8511-efe5af39625e.txt
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+
+--- Page 1 ---
+E/0058 BREAST TISSUE CHECKLIST Specimen type: Radica! mastectomy SON Specimen size: Not specified "//e Tumor site: Breast Tumor size: 2.7 x 2.7 x 2.7 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinoma Histologic grade: Poorly differentiated Tumor extent: Not specified Lymph nodes: 1/11 positive for metastasis (Axillary 1/11) Left, upper Extracapsular invasion of the lymph nodes: Not specified Margins: Not specified outer cted 'yuo vn r fy eyss quadrant epaa Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments:None.
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diff --git a/output/text/9672f2af-2be3-4a35-b3be-e02c990ce7b9.txt b/output/text/9672f2af-2be3-4a35-b3be-e02c990ce7b9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b419eabd230987e9b662015c48ccb2baba0684ec
--- /dev/null
+++ b/output/text/9672f2af-2be3-4a35-b3be-e02c990ce7b9.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:F7280EE2-0A62-4DE5-8A20-1786F8851F41 TCGA-NH-A5IV-01A-PR Redacted RUN DATE: RUN TIME: bry RUN USER: PATIENT: ACCT #: LOC: 1 U#: AGE/SX: ROOM : REG REG DR: DOB: BED: DIS: STATUS: TLOC: SPEC #: PERFORMED AT TIME IN FORMALIN: 6:25 hrs CLINICAL INFORMATION: Pre-Op Diagnosis: Colon CA Remarks: Specimen(s): Right colectomy specimen. MICROSCOPIC DIAGNOSIS RIGHT COLON AND PORTION OF TERMINAL ILEUM, RIGHT COLECTOMY:S ADENOCARCINOMA OF TRANSVERSE COLON. LOW GRADE TUMOR MEASURES 9 CM AND INFILTRATES SUB SEROSA SURGICAL MARGINS FREE OF TUMOR NO TUMOR SEEN IN ANY OF 12 REGIONAL LYMPH NODES SEE COMMENT FOR SYNOPTIC REPORT COMMENT(S) CAP APPROVED SURGICAL PATHOLOGY CANCER CASE SUMMARY:S SPECIMEN: Terminal ileum. cecum, ascending colon. transverse colon PROCEDURE: Right hemicolectomy TUMOR SITE: Transverse colon TUMOR SIZE: Greatest dimension: 9 cm MACROSCOPIC TUMOR PERFORATION: Not identified HISTOLOGIC TYPE: Adenocarcinoma HISTOLOGIC GRADE: Low-grade MICROSCOPIC TUMOR EXTENSION : Tumor invades through the muscularis propria into the subserosal adipose tissue or the nonperitonealized. pericolic or perirectal soft tissues. but does not extend to the serosal surface MARG INS : Proximal margin: Uninvolved by invasive carcinoma Distal margin: Uninvolved by invasive carcinoma. Circumferential or Mesenteric Margin: Uninvolved by invasive carcinoma LYMPH--VASCULAR INVASION: Not identified PERINEURAL INVASION: Not identified 1 TUMOR DPOSITS : Not identified PATHOLOGIC STAGING: Primary tumor: pT3 Regional lymph nodes: pNO Number of lymph nodes examined: 12. Numbers of lymph nodes involved: 0. *x CONTINUED ON NEXT PAGE ** LcDo-3 Adenearcincma;N0S S/4o|3 Site Colon, transverse cilon C18.4 J 1//)13
+
+--- Page 2 ---
+PAGE 2 RUN DATE RUN TIME Specimen Inaniry RUN USER: PATIENT (Continued) SPEC #: GROSS DESCRIPTION: The specimen is received in the fresh state from the operating room for immediate gross measures 27 cm in length x i0 cm in circumference. Present in the distal portion of the colon is a fungating. red tumor which measures 9 x 6 x 3 cm. located 6 cm from the distal margin and 3 cm from the radial margin. The terminal ileum measures 14 cm in length x 4 cm in circumference x 1 cm in wall thickness and appears unremarkable. The appendix appears to be surgically absent. A representative section of the tumor is removed by aseptic technique. and the tumor obstructs the lumen. infiltrates the subserosa but does not appear to penetrate the visceral peritoneum. The following sections are submitted: Block 1 proximal margin Block 2 distal margin. Blocks 3-6 colon tumor Blocks 7-9 whole lymph nodes. Block 10 one lymph node trisected Block 11 one lymph node bisected. Block 12 one lymph node trisected Regional adipose tissue resected with the specimen measures 30 x 4 x 2 cm. A relatively small number of lymph nodes is present. These are soft and measure up to 1 cm. INTRAOPERATIVE CONSULTATION: IMMEDIATE GROSS EVALUATION: ADENOCARCINOMA PRESENT IN COLON. PROCESSED FOR TUMOR BANKING Signed (signature on file). ** END OF REPORT ** h 3
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diff --git a/output/text/968c3895-5ef5-4496-af6e-0e0c475ba769.txt b/output/text/968c3895-5ef5-4496-af6e-0e0c475ba769.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8f1867b96a131acb064d22b7e8cd45dc8fd3de0e
--- /dev/null
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+
+--- Page 1 ---
+UUID:F4F870F4-08D1-4BB4-B02F-5553590DD42E8 TCGA-MH-A560-01A-PR Redacted  SURGICAL PATHOLOGY MEDICAL RECORD PATHOLOGY REPORT LEFT LOWER POLE RENAL MASS 1cs-0-3 BRIEF CLINICAL HISTORY: emcins,pagi!ey/nsl cll 824c|3 PREOPERATIVE DIAGNOSIS: renal mass Sit: Kimuy, No; ;Ci4-9 OPERATIVE FINDINGS: 1/>5(1 POSTOPERATIVE DIAGNOSIS: renal mass PATHOLOGY REPORT GROSS DESCRIPTION: The specimen consists of an 8.4 gm, 3.2 x 3.0 x 1.9 cm partial nephrectomy specimen displaying a tan-red, smooth lining consistent with renal capsule.  The renal resection margin is tan-brown and scabrous. The capsular margin is inked black, and the renal resection margin is inked blue. 1.8 x 1.8 x 1.3 cm, tan-brown, mahagony, well-circumscribed mass that is less than 0.1 cm from the renal resection margin and grossly extending to the renal capsule.  The mass does not grossly extend into the perinephric fat.  There is minimal amounts of uninvolved renal parenchyma at the renal resection margin. Also received in the same container is a 3.5 x 3.0 x 1.2 cm aggregate of tan-yellow, fatty soft tissue. Sectioning reveals a tan-yellow,. unremarkable cut surface.. Representative sections are submitted as follows: 1-4- entire partial nephrectomy specimen; 5- fat within the same container. Please note that a representative portion of tumor is taken for tissue bank. MICROSCOPIC EXAM FINAL DIAGNOSIS Kidney, Left lower pole renal mass, partial nephrectomy  PAPILLARY RENAL CELL CARCINOMA, TYPE II (FUHRMAN NUCLEAR GRADE 2) (Surgical Pathology Cancer Case Summary) Surgical Pathology Cancer Case Summary (based on AJcc/uicc TNM, 7th edition) Procedure: Partial nephrectomy Specimen Laterality: Left. Tumor Site: Lower pole Tumor Size: 1.8 CM Tumor Focality: Unifocal - Macroscopic Extent of Tumor: Tumor limited to kidney  Histologic Type: Papillary renal cell carcinoma Sarcomatoid Features: Not identified
+
+--- Page 2 ---
+- Tumor Necrosis: Not identified. Histologic Grade: Fuhrman grade 2. - Microscopic Tumor Extension: Tumor limited to kidney  Margins: Margins uninvolved by invasive carcinoma Lymph-Vascular Invasion: not identified Pathologic Staging: pTla, pNx Lymph nodes: No nodes submitted. Pathologic Findings in Nonneoplastic Kidney: chronic inflammation Comment: Immunohistochemical stains performed on specimen was notified of the preliminary diagnosis at the end of the procedure on PATHOLOGIST (End of report) tw 11f35[12 SQUALIFIED
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diff --git a/output/text/968ec29f-a509-4e6c-b505-c8b9d2b65be0.txt b/output/text/968ec29f-a509-4e6c-b505-c8b9d2b65be0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..be042f77bf89fc95fc770de42c4a47556f5a4139
--- /dev/null
+++ b/output/text/968ec29f-a509-4e6c-b505-c8b9d2b65be0.txt
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+
+--- Page 1 ---
+Redacted I C D -0 - 3 Cavcunorna,mfiltraH'ny duct rVos 850v/3 u 10/2) Sit: hraof Nos C50.9 Final Pathologic Diagnosis: A. Sentinel lymph node #1, left axilla, biopsy: No carcinoma identified in one lymph node (0/1). B. Sentinel lymph node #2, left axilla, biopsy: No carcinoma identified in one lymph node (0/1). Poge I ot12
+
+--- Page 2 ---
+Surgical Pathology - Working Draft C. Left breast, mastectomy: 1. Infiltrating ductal carcinoma, SBR grade 2, 2.4 cm; see comment. 2. Intermediate to high grade ductal carcinoma in-situ, cribriform and comedo types. 3. Non-proliferative fibrocystic changes. 4. Duct ectasia. D. Right breast, mastectomy: 1. Atypical lobular hyperplasia.. 2. Non-proliferative fibrocystic changes. 3. Duct ectasia. 4. Microcalcifications associated with benign ducts and stroma. 5. No carcinoma identified. E. Soft tissue, right breast, excision: Fibroadipose tissue with skeletal muscle; no breast parenchyma or carcinoma identified. F. Left ovary and fallopian tube, salpingooophorectomy: - Ovary: No significant pathologic abnormality. - Fallopian tube: Benign paratubal cyst. G. Right ovary and fallopian tube, salpingooophorectomy: - Ovary: No significant pathologic abnormality. - Fallopian tube: Benign paratubal cyst. H. Omentum, biopsy: Benign fibrous nodule. I. Soft tissue, left upper peritoneum, biopsy: Benign fibroadipose tissue. J. Omentum, omentectomy: No significant pathologic abnormality Note: Breast Tumor Synoptic Comment - Laterality: Left. - Invasive tumor type: Infiltrating ductal. - Invasive tumor size: 2.4 cm maximum diameter. - Invasive tumor grade (modified Bloom-Richardson): Nuclear grade: 3, 3 points. Mitotic count: 7 mitotic figures/10 HPF, 1 point. Tubule/papilla formation: >10% but <75%, 2 points. Total points and SBR grade - 6 points, grade 2. - Lymphatic-vascular invasion: None identified. - Perineural invasion: None identified.. - Invasive tumor necrosis: None identified. - Mononuclear cell reaction: None/minimal. - Resection margins for invasive tumor: Widely clear. - Deep margin: Widely clear; closest distance of tumor 2 cm. - Medial margin: Widely clear; closest distance of tumor > 6 cm. - Lateral margin: Widely clear; closest distance of tumor 2.8 cm.. - Anterior/superior margin: Widely clear; closest distance of tumor 5.5 cm. - Anterior/inferior margin: Widely clear; closest distance of tumor >6 cm.. - Ductal carcinoma in situ (DcIS) type: Cribriform and comedo.. - Ductal carcinoma in situ size: ~2.0 cm in maximum diameter.. - Ductal carcinoma in situ nuclear grade: Intermediate to high grade. - Necrosis in ductal carcinoma in situ: Present. - Microcalcifications: Not identified. Paam 7 nf1?
+
+--- Page 3 ---
+Surgical Pathology - Working Draft - Resection margins for ductal carcinoma in situ: Widely clear (see above for invasive tumor.. - Lobular carcinoma in situ (LCis): Not identified.. - Number of lobules involved: N/A. - Nuclear type/size: N/A.. - Resection margins for pleomorphic lobular carcinoma in situ: N/A. - Lymph node status: Negative. - Number of positive lymph nodes: 0. - Total number sampled: 2. - AJCC/UICC stage: pT2N0Mx. - Nontumorous breast tissue: Non-proliferative fibrocystic change; duct ectasia. - Nipple: Unremarkable.. - Skin/dermis: Unremarkable. Pagetoid spread of carcinoma is seen in benign ducts adjacent to the tumor. No such spread is seen away from the tumor. Atypical lobular hyperplasia is present in the contralateral (right) breast.. An immunohistochemical test for estrogen and progesterone receptors as well as for HER2 was performed on block c3. The test for estrogen receptors is positve. There is moderate nuclear staining in >95% of tumor cells. Internal positive control is positive. The test for progesterone receptors is positive. There is moderate to strong nuclear staining in 90% of. tumor cells. Internal positive control is positive.. Result of HER2/neu test: This carcinoma is negative for HER2/neu oncoprotein over-expression.. An immunohistochemical assay was performed using the CB11 monoclonal antibody to HER2/neu oncoprotein. The staining intensity of this carcinoma was 1 on a scale of 0-3 (HER2 test interpreted by Dr. Carcinomas with staining intensity scores of O or 1 are considered negative for over-expression of HER2/neu oncoprotein. Those with a staining intensity score of 2 are considered borderline. We and others have observed that many carcinomas with staining intensity scores of 2 do not show gene amplification. All carcinomas with staining intensity scores of 2 are therefore submitted for FISH testing. The results of the FISH test are issued directly from the molecular cytogenetics laboratory. Carcinomas with staining intensity scores of 3 are considered positive for over-expression of HER2/neu oncoprotein. Tumors in this category show an excellent correlation between the results of immunohistochemical and FisH testing, and almost always show gene amplification. Intraoperative Consult Diagnosis FS1 (A) Sentinel lymph node #1, left axilla, biopsy: No carcinoma. FS2 (B) Sentinel lymph node #2, left axilla, biopsy: No carcinoma. FS3 (G) Right adnexa, salpingo-oophorectomy: Paratubal cyst with hemorrhage. FS4 (H) Omentum, biopsy: Dense fibrous connective tissue, no carcinoma. FS5 (I) Left upper quadrant, peritoneum, biopsy: No carcinoma. F. Left adnexa, salpingo-oophorectomy: Paratubal cyst (gross diagnosis only). Clinical History. Page 3 of 12
+
+--- Page 4 ---
+Surgical Pathology -. Working Draft The patient is a -year-old woman with left breast cancer. She undergoes bilateral mastectomies Gross Description The specimen is received in ten parts, each labeled with the patient's name and unit number. Parts A through I are received fresh, and Part J is received in formalin. Part A, additionally labeled "1 consists of one pink, unoriented, fibroadipose tissue fragment measuring 1.5 x 0.8 x 0.8 cm. The entire specimen is frozen for frozen section diagnosis 1, and subsequently submitted in cassette A1. Part B, additionally labeled consists of one pink-red, unoriented fibroadipose tissue fragment measuring 1.3 x 0.8 x 0.7 cm. The entire specimen is frozen for frozen section diagnosis 2, and subsequently submitted in cassette B1. Part C is additionally labeled " It consists of a mastectomy specimen, measuring 15.8 cm from superior to inferior, 15.6 cm from medial to lateral, and 8.2 cm from anterior to posterior. The specimen weighs 442.5 gm. In the lateral aspect of the specimen is a spiculated, firm, tan mass, measuring 2.4 x 1.2 x 1.2 cm. This mass is 2.0 cm from the deep margin, 5.5 cm from the superior margin, >6 cm from the inferior margin, 2.8 cm from the lateral margin, and >6 cm from the medial margin. In the anterior-inferior portion of the breast, there are dilated ducts, filled with cheesy material This area is O.2 cm from the deep margin. The remainder of the breast parenchyma is unremarkable. Two pieces of tumor are banked, one for tissue banking and one for the epithelial cell study. Representative sections are submitted as follows: Cassette C1: Nipple. Cassettes C2-C3: Spiculated mass. Cassette C4: Deep margin beneath tumor. Cassette C5: Lateral margin. Cassette C6: Lower outer quadrant. Cassette C7: Lower inner quadrant. Cassette C8: Medial margin. Cassette C9: Upper inner quadrant. Cassette C10: Anterior-inferior area with duct ectasia. Part D is additionally labeled It consists of a mastectomy specimen, measuring 18.2 cm from superior to inferior, 16.2 cm from medial to lateral, and 4.8 cm from anterior to posterior. The specimen weighs 688 gm. A short stitch is designated by the surgeon as superior, and a long stitch is designated by the surgeon as lateral. In the inferior-medial portion of the specimen is a fragment of skin, measuring 7.5 x 4.9 cm. It is white and unremarkable. There is a nipple, measuring 1.3 x 1.5 x 1.6 cm. The specimen is notable for dilated ducts with a viscous, yellow-tan material within them. This material extends into one of the nipple ducts. No masses are noted, nor are any areas suspicious for DCIS appreciated. The anterior-superior portion of the specimen is inked blue, the anterior-inferior portion of the specimen is inked green, and the posterior aspect of the specimen is inked black. Multiple sections of unremarkable breast parenchyma are taken for two studies, including a high-risk study and an epithelial cell study. Representative sections are submitted as follows: Cassettes D1-D2: Nipple and surrounding skin. Cassette D3: Representative section of anterior-inferior breast with dilated duct. Cassette D4: Representative section of lower inner breast with dilated ducts. Cassette D5: Representative section of upper inner breast. Cassette D6: Representative section of medial breast. Cassette D7: Representative section of upper outer breast. Cassette D8: Representative section of upper inner breast. Cassette D9: Representative section of lateral breast. Part E is additionally labeled " It consists of a single irregular fragment of soft, yellow tissue, measuring 5.4 x 3.8 x 1.5 cm. A suture has been placed on one aspect of the specimen and is designated the new margin. That aspect of the specimen is inked black, and the specimen is serially sectioned and entirely submitted in cassettes E1 through E5. Part F is received fresh labeled, It consists of an Page 4 of 12
+
+--- Page 5 ---
+Surgical Pathology - Working Draft ovary, measuring 4.3 x 2 x 0.8 cm, with attached fallopian tube, measuring 0.8 x 0.5 x 6 cm. There is a simple paratubal cyst, measuring 1.5 x 1.5 x 0.5 cm. This is received undisrupted, with a thin 0.1 cm translucent wall, and contains 20 cc of clear fluid. In addition, there is a second small paratubal cyst,. measuring 0.5 x 0.5 x 0.5 cm. The ovary is serially sectioned, and no abnormalities are detected, other than a 0.5 x 0.5 x 0.5 cm small white firm area. The fallopian tube is serially sectioned, and no. abnormalities are detected. Cassettes are submitted as follows: Cassettes F1-F9: Ovary, entirely submitted (firm, white area in cassette F7). Cassettes F10-F12: Fallopian tube, entirely submitted.. Cassette F13: Representative section of the paratubal cyst and smaller, 0.5-cm paratubal cyst. Cassette F14: Representative section of broad ligament. Part G is additionally labeled. It consists of an ovary with attached fallopian tube,. weighing 15.9 gm. There is a disrupted hemorrhagic, cystic mass in the broad ligament, measuring 2.3 x. 1.6 x 1.5 cm, no capsule is visualized. A representative section of the cystic mass is submitted for frozen section diagnosis as FS3. The ovary and tube do not appear involved by the lesion. The ovary is inked. black, it contains a simple corpus luteal cyst measuring 1.5 x 1.6 x 0.8 cm. The ovary measures 3.5 x 3 x 1 cm, and the tube measures 6.5 x 0.8 cm. The ovary and fallopian tube are serially sectioned, and no abnormalities are detected. Cassettes are submitted as follows: Cassettes G1-G6: Ovary, entirely submitted. Cassettes G7-G10: Fallopian tube, entirely submitted.. Cassettes G11-G12: 1 Lesion in broad ligament, entirely submitted.. Cassette G13: Frozen section remnant. Part H is additionally Iabeled ". It consists of an unoriented piece of yellow,. adipose tissue, measuring 5 x 1.3 x 0.4 cm, with a white-tan, soft nodule, measuring 0.3 x 0.3 x 0.3 cm,. attached to one end. This is entirely submitted for frozen section diagnosis as FS4, with the frozen section remnant submitted in cassette H1. The remaining omentum is entirely submitted in cassette H2. Part I is additionally labeled It consists of multiple unoriented. fragments of tissue, measuring 1 x 0.3 x 0.1 cm in aggregate. The specimen is entirely submitted for. frozen section diagnosis as Fs5, with the frozen section remnant submitted in cassette Il.. Part J is additionally labeled It consists of an aggregate of fatty tissue, measuring 4 x 2 x 0.5. cm. No abnormalities are detected. 1ne specimen is entirely submitted in cassettes J1 through J3. 'Pathology Resident Signed: - Fee Codes: Other Specimens Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Right Breast, Fine Needle Aspiration. Final Diagnosis Right Breast, Fine Needle Aspiration: Benign scar tissue, see comment. Page S of i2
+
+--- Page 6 ---
+Surgical Pathology - : Working Draft Specinen Class: Status: Signed Out Accessioned: Signed Out Specimen(s) Received: Vaginal/Cervical/Endocervical, Thin Prep Imaged. Final Diagnosi Vaginal/Cervical/Endocervical, Thin Prep Imaged. NEGATIVE FOR INTRAEPITHELIAL LESION OR MALIGNANCY. Reactive cellular changes. Atrophic changes SPECIMEN ADEQUACY: Satisfactory for evaluation.. Transformation zone components are present.. _Specimen Class: Status: Signed Out Accessioned. Signed Out: Specimen(s) Received: Right Breast, implant capsule. Final Diagnosis Right breast, implant capsule, capsulectomy: Peri-prosthetic capsule. _Specimen Class: . Status: Signed Out Accessioned Signed Out: Specimen(s) Received: Cervical/Endocervical, Thin Prep Imaged Fina! Diagnosi Cervical/Endocervical, Thin Prep Imaged. NEGATIVE FOR INTRAEPITHELIAL LESION OR MALIGNANCY. Atrophic changes SPECIMEN ADEQUACY: Satisfactory for evaluation. No transformation zone components are identified. Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Endometrium, biopsy. Final Diagnosis Endometrium, biopsy: Fragments of benign endocervical tissue and no definitive endometrium, see comment. Page 6 of 12
+
+--- Page 7 ---
+Surgical Pathology : Working Draft ... Speeimen Class:. Status: Signed Out Aecessioned: Signed Out: Specimen(s) Received: Cervical/Endocervical, Thin Prep Imaged Final Diagnosis Cervical/Endocervical, Thin Prep Imaged. NEGATIVE FOR INTRAEPITHELIAL LESION OR MALIGNANCY. Atrophic changes SPECIMEN ADEQUACY: Satisfactory for evaluation. Transformation zone components are present.. Specimen Class: Status: Signed Out Accessione: Signed Out: Specimen(s) Received: A: Left breast capsule, B: Right breast capsule. Final Diagnosis A. Breast capsule, left, excision: Dense fibrous tissue with chronic inflammation. B. Breast capsule, right, excision: Dense fibrous tissue with chronic inflammation.  Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Cervical/Endocervical, Thin Prep Imaged Final Diagnosis Cervical/Endocervical, Thin Prep Imaged. NEGATIVE fOR INTRAEPITHELIAL LESION OR MALIGNANCY. Atrophic changes SPECIMEN ADEQUACY: Satisfactory for evaluation. Transformation zone components are present.. ...Specimen Class: Status: N/A Accessioned: Signed Out: Specimen(s) Received: A: Skin, biopsy, shave, right scalp, B: Skin, biopsy, shave, left scalp, C: Skin, biopsy, punch, left upper arm Final Diagnosis {Final Report Not Signed Out} {Not Entered}  Specimen Class: Status: Signed Out Aceessionet Signed Out Specimen(s) Received: A: Pelvic Washing, B: Diaphragm Washing. Paze 7 of I2
+
+--- Page 8 ---
+Surgical Pathology - Working Draft Final Diagnosis A: Pelvic Washing BENIGN. Reactive mesothelial cells. B: Diaphragm Washing BENIGN. Reactive mesothelial cells. Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Left Breast, Fine Needle Aspiration. Final Diagnosis Left Breast, Fine Needle Aspiration: Adenocarcinoma, morphologically consistent with a primary breast carcinoma. Specimen Class: Status: Signed Out Accessioned Signed Out: Specimen(s) Received: Cervical/Endocervical, Thin Prep Imagede Final Diagnosl Cervical/Endocervical, Thin Prep Imaged. NEGATIVE FOR INTRAEPITHELIAL LESION OR MALIGNANCY. Reactive cellular changes.. SPECIMEN ADEQUACY: Satisfactory for evaluation.. Transformation zone components are present.. Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Right foot foreign body Final Diagnosis Foot, right, excision: Fragment of hyperkeratotic squamous epithelium.. Specimen Class: Status: Signed Out Accessioned Signed Out: Specimen(s) Received: Cytology, GYN, Site Not Specified, Thin Prep. Final Diagnosis Cytology, GYN, Site Not Specified, Thin Prep Page 8 of 12
+
+--- Page 9 ---
+Surgical Pathology - . Working Draft NEGATIVE FOR INTRAEPITHELIAL. LESION OR MALIGNANCY. Reactive cellular changes. SPECIMEN ADEQUACY: Satisfactory for evaluation.. Transformation zone components are present.. specimen Class: Status: Signed Out Accessioned Signed Out: Specimen(s) Received: Cervical/Endocervical, Thin Prep. Final Diagnosis Cervical/Endocervical, Thin Prep. NEGATIVE FOR INTRAEPITHELIAL LESION OR MALIGNANCY. SPECIMEN ADEQUACY: Satisfactory for evaluation.. Transformation zone components are present.. Specimen Class: Status: Signed Out Accessioned Signed Out: Specimen(s) Received: Vaginal/Cervical Endocervical, Direct. Final Diagnosis Vaginal/Cervical/Endocervical, Direct CELLULAR CHANGES WITHIN NORMAL LIMITS. Endocervical cells present.. SPECIMEN ADEQUACY: Satisfactory for evaluation but limited by obscuring white blood cells ...3pecimen Class: Status: N/A Accessioned: Signed Out: Speeimen(s) Received: Skin, biopsy, left chin Final Diagnosis {Final Report Not Signed Out} {Not Entered} Specimen Class: Status: Signed Out Accessloned: Signed Out: Specimen(s) Received: Cervical, Directe Final Diagnosis Cervical, Direct Page 9 of 12
+
+--- Page 10 ---
+Surgical Pathology -. Working Draft CELLULAR CHANGES WITHIN NORMAL LIMITS. Inflammation. SPECIMEN ADEQUACY: Satisfactory for evaluation. Endocervical cells present.. Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Endometrium, biopsy Final Diagnosis Endometrium, biopsy: Benign dyssynchronous secretory endometrium; no hyperplasia or carcinoma identified. Specimen Class: Status: Signed Out Accessioned: Signed Out:  Specimen(s) Received: Cervical.Endocervical, Direct Final Diagnosis Cervical/Endocervical, Direct CELLULAR CHANGES WITHIN NORMAL LIMITS Inflammation. Endocervical cells present. SPECIMEN ADEQUACY: Satisfactory for evaluation but limited by obscuring white blood cells.. _Specimen Class: Status: Signed Out Accessioned Signed Out: Specimen(s) Received: Cervical/Endocervical, Direct Final Diagnosis Cervical/Endocervical, Direct CELLULAR CHANGES WITHIN NORMAL LIMITS SPECIMEN ADEQUACY: Satisfactory for evaluation. Endocervical cells present.  Specimen Class: Status: Signed Out Accessioned Signed Out: Specimen(s) Received: Bladder Washing Final Diagnosis Bladder Washing BENIGN. Pase 10 of 12
+
+--- Page 11 ---
+Surgical Pathology - Working Draft Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Urine, catheterized Final Diagnosis BENIGN. See Below. Specimen Class: Status: Signed Out Accessioned {HighRisk Specimen} Signed Out: Specimen(s) Received: Vaginal/Cervical/Endocervica! Final Diagnosis CELLULAR CHANGES WITHIN NORMAL LIMITS. Squamous metaplasia. SPECIMEN ADEQUACY: Satisfactory for evaluation. Endocervical cells present Specimen Class: Status: Signed Out Accessioned Signed Out: -. Specimen(s) Received: BLADDER WASH Final Diagnosis. BENIGN Conversion Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received:BLADDER WASH Final Diagnosis BENIGN Conversion _Specimen Class: Status: Signed Out Accessloned: Signed Out: Specimen(s) Received: BLADDER WASH Final Diagnosis  BENIGN Conversion Page 1I of 12
+
+--- Page 12 ---
+Surgical Pathology - Working Draft Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: VAGINAL/CERVICAL/ENDOCERVICAL Final Diagnosis  BETHESDA: CELLULAR CHANGES WITHIN NORMAL LIMITS BENIGN Inflammation Conversion Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: URINE, CATHETERIZED Final Diagnosis BENIGN Conversion Specimen Class: Status: Signed Out Aceessioned: Stgned Out: 4 Specimen(s) Received: VAGINAL/CERVICAL/ENDOCERVICAL Final Diagnosis. DESCRIPTIVE DIAGNOSIS Diagnosis Deferred Conversion Status: Signed Out Accessioned: Specimen Class: Signed Out: Specimen(s) Received: SITE NOT SPECIFIED Final Diagnosis DESCRIPTIVE DIAGNOSIS Diagnosis Deferred Inflammation Conversion Status: Signed Out Accessioned Specimen Class: Signed Out: Specimen(s) Received: VAGINAL/CERVICAL/ENDOCERVICAL Final Diagnosis BENIGN Conversion Paxc !2 of 12 FND OF RFPORT
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diff --git a/output/text/96b9e18b-7309-4c8d-9c56-1ca665f96a0e.txt b/output/text/96b9e18b-7309-4c8d-9c56-1ca665f96a0e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..543cf35d1529b9b9904a901020afb20b10520511
--- /dev/null
+++ b/output/text/96b9e18b-7309-4c8d-9c56-1ca665f96a0e.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+tCD-O-3 *ouk Typet Reeik Date Pertormed Byt arcinono, ypajessry Nralobl 8Q60f3 Surgkca! Pathology Reportd MODIFTED- Site BKsdrey NoS Surgical Pathology C4.9 4U 8/9lL3 UUID:99290767-17D6-4EB6-AF0F-0231153F52AE TCGA-SX-A71W-01A-PR Redacted dditional testing LIMICA 7913
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diff --git a/output/text/970c0ace-96ab-410c-994a-b5ae4bce583b.txt b/output/text/970c0ace-96ab-410c-994a-b5ae4bce583b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5b55577bafa88a5a8f13f044bcb7242246b7b937
--- /dev/null
+++ b/output/text/970c0ace-96ab-410c-994a-b5ae4bce583b.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Clinical Diaanosis & History: vith right renal mass. Specimens Submitted: 1: SP: Right kidney & adrenal glan 2: SP: Right paracaval nodes DIAGNOSIS: 1) KIDNEY AND ADRENAL GLAND, RIGHT; RADICAL NEPHRECTOMY: - RENAL CELL CARCINOMA, CHROMOPHOBE TYPE. - THE TUMOR GREATEST DIAMETER IS 18 CM. - THE TUMOR IS CONFINED WITHIN THE RENAL CAPSULE - NO INVASION OF THE RENAL VEIN IS IDENTIFIED. -ALL SURGICAL MARGINS ARE FREE OF TUMOR - THE NON-NEOPLASTIC KIDNEY IS UNREMARKABLE. - THE ADRENAL GLAND IS UNREMARKABLE. 2) LYMPH NODES, RIGHT PARACAVAL; EXCISION:  - EIGHT BENIGN LYMPH NODES (0/8). I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL),AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Special Studies: Result  Special Stain Comment RECUT RECUT RECUT 1) The specimen is received fresh, labeled "Right Kidney and Adrenal Gland". It consists of a kidney, adrenal gland and.  tumor. The specimen measures 19 cm (superior-inferior) x 14.5 cm (anterior-posterior) x 17.2 cm (lateral).The specimen weighs 1,800 grams.The adrenal gland is disrupted and measures 8.7 x 3.1 x 0.7 cm.The ureter measures 6.5 x 0.6 x 0.4 cm.The. tumor measures 18 x 15 x 13.5 cm.  The adrenal gland appears to be uninvolved by tumor.  On the cross section, tumor has a centrally located scar and appears to be light mahogany in color. There are some areas of hemorrhagic. The tumor arises from the superior pole of the kidney and appears to be well-demarcated.  The kidney measures 9.5 x 7.5 x 6 cm. Gross photographs and are taken.The tumor does not involve the kidney pelvis and it has a thin, fibrous membrane around it.The tumor is very friable. Representative sections are submitted. Page 1 of 2
+
+--- Page 2 ---
+Summary of Sections:  MA -- ureteral vascular margins and representative sections of adrenal gland C -- section of tumor with capsule K -- section of uninvolved kidney P -- section of kidney pelvic T - sections of the tumor 2)  The specimen is received in formalin, labeled "Right Paracaval Nodes". It consists of a 4.0 x 2.5 x 1.5 cm aggreate of. fibrofatty tissue fragments with multiple lymph nodes dissected ranging from 0.9 to 2.8 cm in greatest dimension. The largest two Jymph nodes are bisected and each is submitted in a separate cassette. The remainder of the lymph nodes are entirely submitted. Summary of Sections: BLN1 -- first bisected lymph node BLN2 - second bisected lymph node LN - remainder of the lymph nodes Summary of Sections: Part 1:SP: Right kidney & adrenal glanc Block Sect. Site PCs 1 c 1 1 K 1 1 MA 4 1 P 1 7 T 7 Part 2:  SP: Right paracaval node. Block Sect. Site PCs 1 BLN1 2 1 BLN2 2 2 LN 4 Page 2 of 2 END OF REPORT
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diff --git a/output/text/972b2b28-8973-4325-9f83-a7df267d38d3.txt b/output/text/972b2b28-8973-4325-9f83-a7df267d38d3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a1e78f0b8bc604d754775b7a74be020b2a8a28d7
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+E/tts8 BREAST TISSUE CHECKLIST Specimen type: Radical mastectomy Specimen size: Not specified. Tumor site: Breast Tumor size: 1.8 x 1 x 1 cm "e Grossly evident lesion: Yes Histologic type: Infiltrating ductal and lobular carcinoma Histologic grade: Tumor extent: Not specified. Lymph nodes: 7/7 positive for metastasis (Regional 7/7) Right,upper Extracapsular invasion of the lymph nodes: Not specified inner Margins: Not specified quadrant mq :xfIS E-0-00 Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None
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diff --git a/output/text/97520dc5-2f12-4278-9859-2d3f82b2e7b3.txt b/output/text/97520dc5-2f12-4278-9859-2d3f82b2e7b3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fa07a294a737c2f1d46c8a2d779ac268a9a3597e
--- /dev/null
+++ b/output/text/97520dc5-2f12-4278-9859-2d3f82b2e7b3.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+TCGA-AL-3473 SURGICAL PATHOLOGY REPORT Clinical History/Diagnosis: Left renal mass. Source of Specimen(s): 1: Para aortic Lymph Node 2: Kidney resection with Adrenal gland Gross Description: Received in two parts. Source of tissue: 1. Labeled #1, "para-aortic lymph nodes" Gross Description: Received fresh labeled. para-aortic lymph nodes" consists of multiple soft yellow-tan irregular. fibrofatty tissue fragments measuring 5.5 x 4.5 x 2 cm in aggregate. The specimen is sectioned to reveal multiple soft to firm lymph nodes. measuring from 0.3 up to 2.2 cm in greatest dimension. The lymph nodes are entirely submitted in 1A-1D. Designation of Sections: 1A one bisected lymph nodes. 1B-1D multiple additional lymph nodes. ** k***************************************** Source of tissue: 2. Labeled #2, "left kidney Gross Description: Received fresh labeled,. left kidney" consists of a kidney with surrounding perinephric fat. weighing 1,080 grams and measuring 22 x 18 x 9.5 cm. The attached ureter. measures 11.5 cm in length and 0.3 cm in diameter. The ureter is sectioned to show a homogeneous, soft tan-pink smooth mucosal lining with. no ulcerations or polyps present. The specimen is bisected to show a 12.5 x 8.5 x 6 cm kidney. A 7.5 x 6.5 x 5 cm ill-defined variegated midpole mass is identified at approximately 0.5 cm from the closest superior pole capsule. The mass also obliterates approximately 90% of the renal pelvis. Representative sections are submitted in 2A-2I. Designation of Sections: 2A ureteral and vascular margins. 2B-2D tumor closest to capsule. 2E-2F tumor with adjacent uninvolved parenchyma 2G-2I tumor with surrounding fat margin inked black. **************************************x******************** Final Diagnosis: 1. Paraaortic lymph nodes, excision: - Thirty-three lymph nodes with no tumor seen, (0/33) 2. Left kidney, nephrectomy:
+
+--- Page 2 ---
+- Papillary renal cell carcinoma, type 2, (7.5 cm), definitive extrarenal extension not seen. - Vascular and ureteral margins with no tumor seen (pT2N0Mx) Procedures/Addenda FC Cytogenetics Solid Tumor. Results-Comments CYTOGENETIC ANALYSIS REPORTS DIAGNOSIS: Left Renal Mass KARYOTYPE: Abnormal mosaic karyotype: 45,X,-Y[3]/45 49,XY,+7[cp5]/46,XY[15] RESULTS: The renal mass was harvested after eight and ten days in culture. The chromosomes from 23 metaphases were counted and analyzed. and four of these metaphases were karyotyped by G-banding. Three cells had a modal chromosome number of 45 and were missing the Y chromosome Five cells had a modal chromosome number of 47 and contained an extra copy of chromosome 7. Fifteen cells had a modal chromosome number of 46 and appeared to have a normal karyotype.. Procedures/Addenda Addendum Date Ordered:Addendum Diagnosis The nuclear grade of the tumor is equivalent to Fuhrman grade 3.
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diff --git a/output/text/975c0c60-39d0-4a07-808e-f3f1313d5ce9.txt b/output/text/975c0c60-39d0-4a07-808e-f3f1313d5ce9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..881252c45223f23f7a1a7691175b3b05d0c3e5b2
--- /dev/null
+++ b/output/text/975c0c60-39d0-4a07-808e-f3f1313d5ce9.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Icdo-3 FINAL PATHOLOGIC DIAGNOSIS Left simple mastectomy and sentinal node biopsy: Carcinomo, Ihf, 1traImg DuctNo A. Sentinal lymph node #1: Jg50013 -One lymph node, no tumor (0/1). Site: DBreast NoS. B. Sentinel lymph node #2: C 50.9 -One lymph node, no tumor (0/1). WO 12/24/rz C. Left breast (mastectomy): -Intraductal apocrine ductal carcinoma with lobular cancerization and rare foci of invasion (largest focus 3mm), associated with large area of recent hemorrhage (5 cm), see below. -Separate mass of intraductal and infiltrating ductal carcinoma (2.5 cm). inferior to hemorrhagic region. -Small intraductal papilloma, sclerosing adenosis and radial scar lesion. -Calcifications in vessel walls. -Nipple, no tumor.. UUID:AD80BBA3-DA8E-4DFB-BDA1-FFDC131E9740 TCGA-OL-A5D6-01A-PR Redacted Breast Pathologic Parameters 1. Intraductal carcinoma: A. Size: Gross measurement: 5 cm B. Type: Comedo, solid, apocrine C. Nuclear grade: High (Modified Lagios Grading Scheme) D. Associated features: Necrosis, Cancerization of lobules 2. Invasive carcinoma: A. Size: Gross measurement: 1.0 x 1.0 x 0.6 cm B. Composite histologic (modified SBR) grade: III - Architecture: 3 - Nuclear grade: 3 - Mitotic count: 2 C. Associated ductal carcinoma in situ (DCIS): -Within main mass (forming 50 % of tumor volume) -Extending away from main mass 3. Excisional biopsy margins: Free of tumor. Margins greater than 2mm away. 4. Blood vessel and lymphatic invasion: Absent 5. Axillary lymph nodes: Negative for tumor (0/2) 6. Special studies -No expression of ER in invasive tumor nuclei -No expression of PR in invasive tumor nuclei -Her2/neu antigen (FISH): Pending 7. pTNM: pT2,N0,MX
+
+--- Page 2 ---
+Clinical History: This is a  year-old female with history of a right papilloma. A screening mammogram in showed suspicious densities with calcifications in the left outer quadrant. By exam showed a 1.5 cm quasi suspicious mass at 4-5:00, 3 cm outside the areola margin on the left breast. , she had a. FNA of the left breast showing carcinoma. On  breast MRI on the left showed an outer quadrant 4.7 x 3.2 x 3.3 cm enhanced mass with three additional suspicious foci: one anterior and superior to the index mass, one adjacent to the nipple, and one suspicious focus at 12 o'clock. The patient undergoes a left breast sentinel node biopsy and simple mastectomy. Specimens Received: A: Sentinel Node #1 B: Sentinel Node #2 C: Left Breast Mastectomy with Sentinel Node Biopsies Gross Description: The specimens are received in three containers each labeled with the patient' s name and medical record number. A. Container A is further designated 31. sentinel node #14. Received for frozen section diagnosis is a 1.8 x 1.2 x 0.5 cm rubbery portion of yellow, lobulated tissue with blue discoloration. It is read as 3one lymph node, negative for carcinoma4 by The specimen is entirely submitted as A1FS. B. Container B is further designated 32. sentinel node #24. Received for frozen section diagnosis is a 1.5 x 0.8 x 0.8 cm portion of pink-tan rubbery tissue consistent with a lymph node. It is bisected and read as 3one lymph node, negative for carcinoma4 by The specimen is entirely submitted in cassette B1FS in a mesh bag. C. Container C is further designated 33. left breast mastectomy with sentinel node biopsies4. Received fresh and placed in formalin is a 975 gm, 39 x 18 x 6 cm mastectomy specimen with an ellipse of white-tan skin with blue discoloration (27 x 11.2 cm), areola (4.7 x 4.5 cm), and nipple (1.2 x 1.0 x0.4 cm). The specimen is oriented as follows: short suture superior, long suture lateral. The deep margin is inked black and the specimen is serially sectioned into 13
+
+--- Page 3 ---
+slices from lateral (slice #1) to medial revealing a 5 x 5.5 x 4 cm ecchymotic area in the lower lateral quadrant located in slices #4-7. There is a well-circumscribed, firm, white mass measuring 2.5 x 1.7 x 1.5 cm in slice #5, 5.5 cm from the deep margin. It is located inferior to the ecchymotic region. At 2-3 o'clock adjacent to the firm mass is an ill-defined, gritty, indurated area primarily in slices #7 and #8. It extends superomedially with a span of 5.0. x 3.5 x 2.0 cm and is located 2.5 cm from the deep margin. Note: slices #7 and. #8 contain the nipple and areola region. Cassette SummaryC1: nipple C2-C4: areola, serially sectioned C5: section of the main mass in slice #5 with respect to closest distant from deep margin C6-C7: one representative section immediately superior and anterior to the main lesion from slice #5 C8: section of hematoma from slice #5 anterior and medial to the main lesion C9: section of hematoma from slice #6, directly medial to the main lesion. C10: section 2 cm superior, anterior, and medial to the main lesion from slice #7 C11: representative sections from slice #8, representing ill-defined, gritty, firm tissue C12-C13: section from slice #7 also representing ill-defined, gritty, firm tissue C14: another section from slice #7 immediately inferior to the section C12-C13 C15-C16: section from 12 o'clock on section #8 C17-C18: sections from slice #9 C19: another representative section from section #9 C20-C21: lateral upper quadrant from slices #3-4, respectively C22-C23: lateral lower quadrant from slices #2 and #3, respectively C24-C25: upper medial quadrant from slice #11 and #12, respectively C26-C27: medial lower quadrant from slices #11 and #12, respectively Intraoperative Consult Diagnosis: A1FS. Sentinel node #1: One lymph node, negative for carcinoma B1FS. Sentinel node #2: One lymph node, negative for carcinoma..
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diff --git a/output/text/979dd53f-6d0e-4987-82ad-5176daf5f6cf.txt b/output/text/979dd53f-6d0e-4987-82ad-5176daf5f6cf.txt
new file mode 100644
index 0000000000000000000000000000000000000000..08992d168bf4aa25ef6ce8d1d2f9f165f48635db
--- /dev/null
+++ b/output/text/979dd53f-6d0e-4987-82ad-5176daf5f6cf.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:914A8783-5ACF-4580-A663-E73BDDAA7286 TCGA-OR-A5L1-01A-PR Redacted TcDo-3 Crcinsmc, adrenal csrtrca! 83703 Procedure: most likely L adrenalectomy and nephrectomy 8ite:OAdrwalGard Csr+ex C74 D Gross description: 9 x 8 x 4cm, 185.2g J xk[13 Diagnosis: adrenocortical carcinoma Reference Pathology:. Diagnosis: adrenocortical carcinoma, Ki67 30% Weiss score: 5 Hough score: 4.5. Van Slooten score: 14.7
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diff --git a/output/text/97a8b1db-458e-4d03-9a78-14ea33af7cd4.txt b/output/text/97a8b1db-458e-4d03-9a78-14ea33af7cd4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f6bc237cf11ad8dc6c2ba8b3a41e9990a9f02d19
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:5319D80A-3DFD-4834-A905-D34E668D4A2F TCGA-AY-AS4L-01A-PR Redacted Diagnosis: A: Colon, right, resection. Tumor Histologic Type: Invasive colonic adenocarcinoma (see comment) Histologic Grade: Low grade, grade 2 of 4 (moderately differentiated) Tumor Size: 3.4 cm in diameter Tumor Location: Right colon. Depth of Invasion: To junction between muscularis propria and subserosal soft tissues; no definite extension beyond muscularis propria identified (SmA immunostain performed) Lymphovascular Invasion: Not identified Le do-3 Adencaren eina, NDS Perineural Invasion: Not identified 8)40/3 Sit: Path R Colon C16,2 Margins: Proximal margin: Negative, 16 cm away C$CF HpfcF1ure C18.i Distal margin: Negative, 8.1 cm away FU i2)3)3 Mesenteric margin: Negative, 5.4 cm away Regional Lymph Nodes: Total number with metastases: 0 Total number examined: 24 IHc for Mismatch Repair Protein Expression: MLHl: Normal expression. PMS2: Normal expression Msh2: Normal expression MSh6: Normal expression. Additional Pathologic Findings: Submucosal lipoma; Fibrous obliteration of distal appendiceal lumen; Separately submitted omentum with no involvement by carcinoma identified AJCc Pathologic TNM Stage: pT2 pN0
+
+--- Page 2 ---
+Note: This pathologic stage assessment is based on information available at the time of this report and is subject to change pending clinical review and additional information. Comment: Materials will be submitted to the. for microsatellite instability testing. These results will be issued in a separate report. Clinical History: with colon cancer. Gross Description: Received is one appropriately labeled container, additionally labeled "right colon and omentum." It consists of a 2.9 cm long x 1.6 cm in circumference terminal ileum contiguous with a 26.8 cm long x 6.0 cm in. circumference large bowel with attached vermiform appendix (4.7 cm long x 0.5 cm in diameter), omentum (13.9 x 4.7 x 1.3 cm), and pericolonic fat extending the length of the specimen up to 3.6 cm thick. There is a 3.4 x 2.7 x 0.7 cm firm gray/tan mass with raised borders that is 16.7 cm from the proximal margin and 8.1 cm from the distal margin. The mass extends 0.3 cm into the muscularis propria but not through it,. 0.6 cm from the serosa (inked black), and 5.4 cm from the mesenteric margin (inked red). Proximal to the mass by 7.7 cm is a 1.0 x 0.7 x 0.4 cm. submucosal fatty nodule that is 7.3 cm from the ileocecal valve. The appendix is. unremarkable. Also received in the same container is a 31.4 x 11.5 x 2.2 cm focally red/brown
+
+--- Page 3 ---
+segment of lobulated adipose tissue consistent with omental tissue. The pericolonic adipose tissue is dissected for lymph node candidates of which 21. are identified, ranging from 0.2 cm in greatest dimension up to. 0.8 x 0.8 x 0.7 cm. The lymph nodes are firm and white. Tumor and normal are given to Block Summary: Al - proximal margin, en face A2 - distal margin, en face. A3 - mesenteric margin, en face A4-A7 - mass, deepest extension A8 - submucosal fatty nodule A9 - appendix A10 - separate segment of omentum Al1-Al3 - each contains five lymph node candidates A14-A16  - each contains two lymph node candidates, bisected, one is inked black
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diff --git a/output/text/97cfb578-7129-4d75-85ec-8b0a06cb338f.txt b/output/text/97cfb578-7129-4d75-85ec-8b0a06cb338f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..11c94b5efe60a091da81e76a22f702eeda9b1a34
--- /dev/null
+++ b/output/text/97cfb578-7129-4d75-85ec-8b0a06cb338f.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+PATIENT HISTORY: Colon mass. prE-OP DIAGNOSIS: Colon mass. Post-OP Diagnosis: Same. PROCEDURE: Laparoscopic colectomy attempted, open right colectomy done. FINAL DIAGNOSIS: Segment of terminal Ileum and Right hemicolectomy -- A. INVASIVE WELL-DIFFERENTIATED COLON ADENOCARCINOMA a. 0.9 Cm InVAsive tumOr IntO SUb-mucOSA b.  INVASIVE CARCINOMA ARISING IN A 2.5 CM GREATEST DIMENSION TUBULOVILLOUS ADENOMAS With serrated features. B. ADDITIONAL NON-INVASIVE ADENOMAS: 2 TUBULOVILLOUS ADENOMAS (2.9 CM AND 1.5 CM) AND 1 TUbular ADenoma (1.0 Cm).  RESECTION MARGINS ARE FREE OF CARCINOMA AND ADENOMA. D.  NO ANGIOLYMPHATIC INVASION IS SEEN. E.  Sixteen benign Lymph nodes (0/16). F. PaTHOLOgIc STage; T1 nO mX. G. TErmINal ILeUm WIth nO SigNIFiCant PAThOLOgIC CHanGE. H. APPENDIX WITH TUBULAR CARCINOID TUMOR. a. TuBUlAr CArcInoiD ArI$es in The AppenDIx TIp. b. TUBULAR CARCINOID MEASURES 3MM. C. (see comment). COmmENT: Immunohistochemical stains were performed on the appendix (slide C). Appendix tumor cells are weakly positive for. glucagon and positive for CDX2, mCEA, pancytokeratin, and synaptophysin. It is negative for estrogen receptor, prcgesterone receptor, chromogranin , and p53. These findings are compatible with a tubular carcinoid. CASE SyNOPSIS: Synoptic data - primary colon, rectal, Appendix tumors SPECIMEN TYPE: Right hemicolectomy Specimen Length: 22.5 cm Tumor site: Cecum TumOR CONFIgURATION: Arising in a polyp TUMOR SIZE: Greatest dimension: 0.9 cm INTACTNESS OF MESORECTUM: Not applicable HISTOLOGIC TYPE: Adenocarcinoma HISTOLOGIC GRADE:S Low-grade (well to rmoderately differentiated) PATHOLOgIC STAGING (pTNm): pT1 pNO Number of nodes examined: 16 Number of nodes involved: 0 pMX MARGINS:  Proximal margin uninvolved by invasive carcinoma  Distal margin uninvolved by invasive carcinoma Circumferential (radial) margin - Not applicable ANGIOLYMPHATIC INVASION: Absent PERINEURAL INVASION: Absent Tumor boRDer conFiguratIOn: Pushing TUMORAL LyMpHOCYTIC RESPONSE: None ADOITIONAL PATHOLOGIC FINDINGS: Adenoma(s) Other polyps (type[s]):2 tubulovillous adenomas, 1 tubular adenoma. SpECIAL PROCEDUReS: Microdissection Genotyping Interpretation Molecular Anatomic Pathology testing for Microsatellite Instability: A. No microsatellite instability detected (Microsatellite stable) B. Immunohistochemistry for the hMLH1, hMSH2 and hMSH6 showed preserved gene expression. Note: The specimen was analyzed by PCR for microsatellite instability because the patient met one or more of the recently recommended criteria for testing (1). The five recommended dinucleotide and mononucleotide polymorphisms were utilized to assess for microsatellite instability (MSl). zERO of five markers showed evidence of microsatellite instability.. Additionally, the immunohistochemistry for hMLH1, hMSH2 and hMSh6 demonstrated preserved nuclear staining in the neoplastic.
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diff --git a/output/text/97e59460-6e37-4227-b493-fd3330839d0d.txt b/output/text/97e59460-6e37-4227-b493-fd3330839d0d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..32dc07e6ce7ad2d5fb1cd74c7b460bf41e2b0853
--- /dev/null
+++ b/output/text/97e59460-6e37-4227-b493-fd3330839d0d.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+Accession Number: Report Status:. Type: Surgical Pathology Specimen Type: Kidney, partial or total resection Procedure Date: Ordering Provide CASE: PATIENT:  TCGA-CZ-4862 PATHOLOGIC DIAGNOSIS: 1. A./LEFT KIDNEY, NEPHRECTOMY: CLEAR CELL RENAL/CELL CARCINOMA, present as two separated nodules in the posterior mid-to-upper pole (4.7 cm) and at the anterior subcapsular (1.0 cm). Fuhrman nuclear grade 2.. The tumor is confined to the kidney. The vascular and ureteral margins are negative for tumor.. Adrenal gland not present. AJcc Classification: Tlb Nx MX.. PAPILLARY ADENOMA (0.3 cm), located in the subcortex. Incidental microadenoma, 0.1 cm. Focal global glomerulosclerosis. Cortical scar Arteriolosclerosis, mild to moderate. The renal parenchyma and special stains will be reviewed by Kidney. Pathology Service, and reported in an addendum.. CLINICAL DATA: History: None given. Operation: Left radical nephrectomy. Operative Findings: None given. Clinical Diagnosis: Left renal cell cancer.. TISSUE SUBMITTED: A/1. Left kidney - Tissue Bank. GROSS DESCRIPTION: The specimen is received fresh, labeled with the patients name, unit number, and "#1 Left kidney", and consists of a left radical nephrectomy specimen (653.5 grams, 21 x 9.5 x 6.8 cm  Overall dimensions), to include ieft kidney. (13.0 x 8.0 x 5.8 cm), ureter (10.5 cm in length x 0.4 cm in diameter), renal vein (0.6 cm in length x 1.3 cm in diameter), renal arteries (1.4 cm in length x 0.3 cm in diameter and 2.2 cm in length x 0.4 cm in diameter), and abundant perinephric fat. An adrenal gland is not identified. A small portion of red/tan probable Gerota's fascia (6.2 x 3.7 x 0.1 cm) is present along the anterior aspect. The specimen is inked black along the deep margin and bivalved. There 3.0 cm) along the posterior aspect of the mid to upper pole, abutting the renal. capsule, coming to within 0.8 cm of the deep margin, 2.5 cm from artery #2, 3.2 cm from artery #1, 3.8 cm from the renal vein margin, 13.5 cm from the ureteral. margin, and does not grossly appear to extend in the perinephric fat. The renal vein is grossly unremarkable. Representative tumor is submitted to Cytogenetics, Electron Microscopy, and Tissue Bank for special studies. Representative normal cortex is submitted to the Tissue Bank and Electron encapsulated, golden yellow/red mass (1.0 x 0.9 x 0.7 cm) in the renal cortex, abutting and distending the anterior renal capsule, coming to within 0.5 cm of the black-inked deep margin, 14 cm from the ureteral margin, 5.5 cm from renal artery margin #1, 7.2 cm from renal artery #2, and 5.3 cm from the renal vein margin. There is a small < 0.2 cm nodule in the cortex. The medullary pyramids are diffusely hyperemic at the periphery and the corticomedullary junction is distinct. The pelvis displays an unremarkable tan urothelium. No lymph nodes identified within the hilum.
+
+--- Page 2 ---
+Micro Al: Ureter, renal  yein and renal artery margins, 4 frags,* Micro A2: "T1", 2 frags, Micro A3: "T2", 2 frags, Micro A4-A6: Renal mass at posterior aspect to include deepest extension, 3 Erags: 4icro A7: Posterior renal mass in relationship to pelvis, 1 frag, Micro A8:yRentaI>mass in relationship to adjacent renal parenchyma, ++ty... R$S. Z...ma licro AA Anterior upper pole mass at deepest extension, 2 frags total, .ss icro Corticomedullary junction, 1 frag, Al licro(A12)  Remainder upper pole mass, 1 frag, Micro A13: Additional small nodular area (<0.2 cm), 1 frag, By his/her signature below, the senior physician certifies that he/she personally conducted a microscopic examination ("gross only" exam if E so stated) of the described specimen(s) and rendered or confirmed the diagnosis(es) related thereto.. RENAL PATHOLOGY EVALUATION OF THE KIDNEY PARENCHYMA: LEFT KIDNEY, NEPHRECTOMY : IMMUNE COMPLEX MEDIATED GLOMERULONEPHRITIS, PREDOMINANTLY WITH SUBEPITHELIAL AND INTRAMEMBRANOUS DEPOSITS, MOST SUGGESTIVE OF A MEMBRANOUS PATTERN OF GLOMERULAR INJURY (SEE NOTE) MODERATE CHRONIC CHANGES OF THE KIDNEY PARENCHYMA: FOCAL GLOBAL GLOMERULOSCLEROSIS (18 % OF GLOMERULI); - MILD TUBULAR ATROPHY AND INTERSTITIAL FIBROSIS (IO% OF THE) PARENCHYMA); - ARTERIAL AND ARTERIOLAR SCLEROSIS, MODERATE (SEE NOTE)S NOTE : The immunofluorescence and electron microscopic evaluation of the tissue suggests an immune complex mediated glomerulonephritis. Electron microscopic evaluation shows that the majority of the deposits are subepithelial and intramembranous in location. This pattern of injury suggests a membranous nephropathy, currently probably not very active. A systemic autoimmune disease (SLE) or a remote post-infectious glomerulonephritis cannot be 'ruled out with absolute certainty..
+
+--- Page 3 ---
+Pathorogy Repor Kidney Pathologist, performed the evaluation and interpretation of this material. DESCRIPTION: formalin-fixed, paraffin-embedded tissue (block Al1) were evaluated Sections Of using HE, PAs, Jones silver methenamine, and AFog (trichrome) stains; an HE-stained'frozen section and semithin submitted for light microscopy. The sample consists of renal cortex and medulla.  There are up to 173 glomeruli present in the sample. Thirty- two (32) glomeruli are globally obsolescent (sclerosed).  The preserved glomeruli show a mild increase in mesangial matrix as seen on the PAs stain. The peripheral capillary walls reveal thick basement membranes, with fine "spike"-like projections and many "craters". These changes are best visible on the Jones' silver methenamine stain. Tubules show normal. cellular details. distal tubules.  Focal tubular atrophy is seen in areas of interstitial fibrosis. Significant interstitial~inflammation is not evident in the sample examined.  Approximately 10 % of the tissue included in this biopsy shows tubular atrophy and interstitial fibrosis, (AFOG).  Arteries show moderate sclerosis of the media, with focal replacement of smooth muscle cells by connective tissue. Arterioles reveal moderate. subintimal hyaline accumulation toluidine blue-stained sections were also. evaluated by light microscopy. IMMUNOFLUORESCENCE MICROSCOPY REPORT Sections of frozen tissue were incubated with antibodies specific for the heavy. chains of IgG, IgA, and Igm, kappa and lambda light chains, c3, C1q, albumin,
+
+--- Page 4 ---
+and fibrin-related antigens. The sample consists of kidney cortex and. medulla.. There are four (4) granuiar deposition of IgM (trace), Igc (+/4+) and fibrinogen (+/4+) in the mesangial areas and along the peripheral capillary walls. There is also diffuse linear deposition of albumin (+/4+) along all basement membranes.. Tubules contain reabsorbed proteins (albumin, IgG, c3) in the form of cytoplasmic granules. Tubular basement membranes reveal focal deposition of c3 (trace). Few casts in distal tubules are reactive for polyclonal IgA. The interstitium reveals scattered fibrin deposits. There is no difference noted in the intensity of the staining for kappa and lambda light chains in the casts, in the deposits, or in the background of the tissue ELECTRON MICROSCOPY REPORT Blocks: 4; Blocks examined: sections; 1 thin section. The tissue examined at the ultrastructural level includes five (5) glomeruli. The glomerular capillary walls are greatly distorted by the presence of. thickening of the basement membranes. Individual deposits are often surrounded by basement membrane material and "spikes".  The electron dense deposits are finely granular but they do not show organized substructures. There is. widespread microvillous degeneration of the epithelial cell membrane. Several epithelial cells also show prominent vacuoles and increased numbers of lysosomes. Glomerular endothelial cells appear unremarkable and do not contain tubuloreticular structures. Subendotheliai electron dense deposits are not seen. The mesangium shows normal cell elements and an extracellular matrix with few irregular electron dense deposits.
+
+--- Page 5 ---
+Accession Number: Report Status: Final Type: Cytogenetics CASE:  PATIENT: SS Cytogeneticist. KARYOTYPE : T1: 45,XY,-8[10] T2: 45,XY,-8[10] METAPHASES COUNTED:20 ANALYZED: 10 SCORED: 10 BANDING: GTG INTERPRETATION : Two different specimens were received from this tumor. Loss of one chromosome 8, as the sole chromosome abnormality, was seen in both specimens. This aberration is not known to be characteristic of any particular type of tumor. COMMENTS : Mosaicism and small chromosome anomalies may not be detectable using the standard methods employed. Chromosome analysis was performed at a level of 400 bands or greater. INDICATION FOR TEST: ? RCC
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diff --git a/output/text/981f8be9-a131-484c-9a42-682145481f94.txt b/output/text/981f8be9-a131-484c-9a42-682145481f94.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c29206cfaf608883a3d3db74cdbafe2699a3ee37
--- /dev/null
+++ b/output/text/981f8be9-a131-484c-9a42-682145481f94.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Date Coll: SURGICAL PATHOLOGY REPORT SPECIMEN Extended right hemicolectomy CLINICAL NOTES PRE-OP DIAgnosI: Hepatic flexure carcinoma. GROSS DESCRIPTION Received fresh labeled "extended right hemicolectomy" is a. previously unopened 26 cm. segment of proximal right colon with attached 8 cm. of distal ileum surfaced by smooth to slightly. scabrous tan pink serosa with a moderate amount of mesocolon, mesentery, and unremarkable omentum. An unremarkable 3.5 cm. appendix a averaging 0.8 cm diameter is present. A focus of serosal retraction including a portion of omentum is noted at the. distal end of the specimen. The overlying surface is inked blue.. On opening, there is a circumferential, 4.8 x 3.2 cm. tan white tumor located 8 cm. from the distal margin. The tumor has a maximal thickness of 1.5 cm.  grossly extending through the muscularis to within O.1 cm. of the inked free radial serosal surface. The tumor appears to extend into the retracted and adherent omentum (see. blocks 2 and 3). A portion of tumor and a portion of normal mucosa are submitted for tissue procurement as requested.. The proximal and distal margins of the specimen measure 3.7 and 6.6 cm. in circumference respectively. The ileal and remaining colonic mucosa is glistening tan pink with regular folds and the walls average 0.5 . in thickness.  No additional mass lesion or abnormality is identified. A few soft to slightly rubbery pale tan white to tan pink tissues in keeping with lymph nodes measuring up to 1.0 cm. in. greatest dimension are recovered from the attached mesocolon and mesentery. Representative sections are submitted in 12 blocks as labeled. BLOCk suMMARy: 1 - Proximal and distal margins; 2 and 3 - tumor. extending into associated omentum; 4 - tumor to closest inked free radial serosal surface; 5 - tumor to normal mucosa; 6 - IcB; 7 and 8  random from remainder of colon; 9 - appendix; 10 and 11 - eig whole lymph nodes per cassette; 12 - seven whole lymph nodes. MICROSCOPIC DESCRIPTION Histologic type:. Adenocarcinoma. Histologic grade:  High-grade (poorly differentiated) Primary tumor (pT): The tumor extends through the full thickness of the wall and through the pericolonic adipose tissue to the serosal surface, pT4a. Proximal margin: Negative for tumor.. Distal margin: Negative for tumor. Circumferential (radial) margin: Tumor extends to within less than. 1 mm of the radial margin. Distance of tumor from closest margin: 8 cm from the distal margin Vascular invasion:  Areas highly suspicious for vascular invasion identified.
+
+--- Page 2 ---
+Regional lymph nodes (pN): pN0 (0/25) Non-lymph node pericolonic tumor:  Perineural invasion is identified. Distant metastasis (pM) :  pMx Other findings:  Ileocecal valve lipoma. Appendix with fibrous obliteration of the tip. DIAGNOSIS Colon, right, hemicolectomy - Invasive poorly differentiated adenocarcinoma (see tumor characteristics in the microscopic description). mber of lymph nodes to microscopic template. End Of Report
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diff --git a/output/text/982541c7-9e68-4b2c-b4eb-cb26e0de3134.txt b/output/text/982541c7-9e68-4b2c-b4eb-cb26e0de3134.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9cd5988b485dd397dfdcc7afea7043768d1351e3
--- /dev/null
+++ b/output/text/982541c7-9e68-4b2c-b4eb-cb26e0de3134.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:669554D5-C608-4028-B24E-1F2129FA0925 TCGA-DK-AA6X-01A-PR Redacted SURGICAL PATHOLOGY REPORT Patient Name: Accession #: Med. Rec. #: Date of Procedure: DOB: (Age Location: Date of Receipt: Gender: M Service: Urology Date of Report: Ref. Physician: Account #: Patient Address: Billing Type: Additional Copy to: Ref. Source: Clinical Diagnosis & History: Bladder mass, high grade Ta on outside pathology Specimens Submitted: 1: Left lateral bladder wall DIAGNOSIS: IDo3 1. Left lateral bladder wall: arsinim, ursThlsS NOS Tumor Type: 8120/3 Invasive urothelial carcinoma with glandular differentiation Site. Msslde, dotraluall Histologic Grade: CL72 High grade Pattern of growth of the non-invasive component: Papillary and flat Local Invasion: Muscularis propria Vascular Invasion: Not identified cOMMENT: By immunostains, the tumor was positive for p63 (4A4) and CK7 and negative for PSA, PSMA and ERG. Some of the immunohistochemistry and ISH tests were developed and their performance characteristics were determined by the Department of Pathology. They have not been cleared or approved by the US Food and Drug Adm I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL). AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. *** Report Electronically Signed Out *** Gross Description: 1) The specimen is received in. , labeled "left lateral bladder wall", and consists of multiple pieces of tan soft tissue ranging from 0.2 to 1.2 cm. The specimen is entirely submitted one cassette. TPS taken. Summary of sections: Summary of Sections: Part 1: Left lateral bladder wall. Blocks Block DesignationPCs Page 1 of 2
+
+--- Page 2 ---
+SURGICAL PATHOLOGy REPORT {not entered} 6 Special Studies: Special Stain Result Comment NEGATIVE. VIMEN PSA PSMA 4A4/P63 ERG CK7 IMM RECUT 18/14 Discrepancy 943513  Page 2 of 2 END OF REPORT
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diff --git a/output/text/9834d89d-3dd1-47e8-adc4-bc742de5aec7.txt b/output/text/9834d89d-3dd1-47e8-adc4-bc742de5aec7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f23f60318620fe97adc7c52df703e175ecf38c29
--- /dev/null
+++ b/output/text/9834d89d-3dd1-47e8-adc4-bc742de5aec7.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SPECIMEN Sigmoid colon CLINICAL NOTES PRE-OP DIAgNOsIS: Sigmoid colon cancer GROSS DESCRIPTION Received fresh and subsequently fixed in formalin is a partially opened colon which is 24 cm long. One end of the specimen is stapled and inked blue; the opposite end of the specimen is opened and is inked black. No orientation of the specimen is given. No retroperitoneal reflection is grossly identified. There is a suture on the surface of the serosa.. The serosa is pink-tan smooth glistening and the remainder of the specimen is partially covered with abundant yellow lobular fat. The suture is located 7.5 cm from the black inked end. The specimen is. opened to show pink-tan smooth glistening mucosa with normal to abundant folds having an average circumference of 4.5 cm and showing multiple diverticula present. There is also a 2.7 x 2.2 x 0.4 cm tumor which is located 7.5 cm from the black inked end. This is in. the same area as the suture. The cut surface of the tumor shows minimal invasion into the muscularis propria showing no discrete invasion into the fat. No other discrete gross lesions are. identified in the mucosa. No submucosal aphthoses or perforation are grossly identified. Lymph nodes are grossly identified in the. fat. Representative sections of the specimen are submitted as follows: Block 1 - representative luminal margins; Blocks 2-4 representative sections of tumor to normal and tumor to fat; Block. representative section of diverticula; Block A6 - nine possible lymph nodes; Block A7 - two possible lymph nodes; Block A8 - nine sible lymph nodes; Block A9 - four possible lymph nodes. Rs-9.
+
+--- Page 2 ---
+MICROSCOPIC DESCRIPTION Histologic type: Adenocarcinoma. Histologic grade:  Moderately-differentiated Primary tumor (pT2): Carcinoma is into but not through muscularis propria Proximal/distal/radial margin: Negative Vascular invasion: Negative Regional lymph nodes (pN): Sixteen negative lymph nodes (0/16) Non-lymph node pericolonic tumor: Not identified 5 DIAGNOSIS Colon, sigmoid, segmental resection: Adenocarcinoma, moderately-differentiated, invading into but not through the muscularis propria.. Sixteen negative lymph nodes (0/16). End Of Report.
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diff --git a/output/text/986e79e8-300e-4974-82cd-1aa94b4a6695.txt b/output/text/986e79e8-300e-4974-82cd-1aa94b4a6695.txt
new file mode 100644
index 0000000000000000000000000000000000000000..26bfacd3d97290122d20e3361301de009106bea3
--- /dev/null
+++ b/output/text/986e79e8-300e-4974-82cd-1aa94b4a6695.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Ics-0 -3 85 00/3 hs.3/28/u S.te,bust nis .c50.9 PATIenT hISTOry:  DATE OF LMP: Prxcedure Date:a DATE OF LAST DELIVERY: : PRE-OP DIAGNOSIS: CARCINOMA LEFT BREAST POST-OP DIAGNOSIS: SAMF OPERATIVE PROCEDURE: EXC: BREAST LEtT BR FS - J.EFT MOD RAD MASTECTOMYS CLINICAL HISTORY:S MATERIAL SUEMITTRD: A) LEET BREAST BIOPSY/TISSUE, PROCUREMENT BY SURGICAL PROCEDURE B) LEFT (MOD) RADICAL MASTECTOMY, PROCUREMENT BY SURGICAL PROCEDURES and axillary contents INTRAOPERATIVE CONSULTATION: ER/fR taken. Iissue taken tor DNA studies.. FINAL DIAGNOSIS: FINAL DIAGNOSIS: ASAFS)" LEFT BREAST AND AXILLA: 4.0C POOR NUCLEAR GRADE INFILTRATING DUCTAL CARCINOM. "MICROSCOPIC FOCI OF DUCTAL CARCINOMA IN SITU ANGIOLYMPHATIC AND PERINEURAL INVASION SEEN TUMOR INVOLVES SKZLETAL MUSCLE RESECTION MARGINS ARE FREE OF CARCINORA TWO or SIXTEEN (2/16) LYMPH NODES ARE POSITIVE FOR CARCINO UUID:53181E8E-9936-42E0-B49B-39C61DD4E943 Redacted TCGA-BH-A204-01A-PR
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diff --git a/output/text/988a9ca4-9200-4aa9-a2f2-a96d02686c86.txt b/output/text/988a9ca4-9200-4aa9-a2f2-a96d02686c86.txt
new file mode 100644
index 0000000000000000000000000000000000000000..aab0b8c1cb9348288e120fcdb53337015b006577
--- /dev/null
+++ b/output/text/988a9ca4-9200-4aa9-a2f2-a96d02686c86.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:C5C5D704-2558-4D48-9378-338091132882 TCGA-LL-A5YO-01A-PR RUN DATE: Redacted RUN TIME: PAGE 1 RUN USER: Lab Database: PATIENT: LOC: U#: AGE/SX : ROOM: REG : REG DR: DOB: BED: DIS: STATUS : TLOC : SPEC #:1 RECD : COLL : TIME IN FORMALIN: 7:21 hrs. CLINICAL INFORMATION: Pre-Op Diagnosis: Left breast cancer Remarks: Specimen(s) : A. Left breast lumpectomy B. Left breast new lateral margin IcD o-3 C. Left axillary sentinel node 'avcinomo, cuctal inf, Itrahif NDS 8s00/3 MICROSCOPIC DIAGNOSIS Site DBras+NoS. C50.9 A LEFT BREAST TISSUE. LUMPECTOMY: JtJ 4/2|13 INFILTRATING DUCTAL CARCINOMA MODIFIED NOITINGHAM HISTOLOGIC GRADE 3 OF 3: NUCLEAR SCORE 3 OF 3. TUBULE FORMATION SCORE 3 OF 3. MITOTIC SCORE 3 OF 3 (11 MITOTIC FIGURES PER SQUARE MILLIMETER) NO DUCTAL CARCINOMA IN SITU IDENTIFIED INVASIVE TUMOR MEASURES 13 MM LATERAL SURGICAL MARGIN OF THIS SPECIMEN FOCALLY INVOLVED (RE-EXCISED BELOW). TUMOR PRESENT 2 MM FROM MEDIAL MARGIN SEE COMMENT FOR SYNOPTIC REPORT B. EXCISION LESION BREAST TISSUE, NEW LATERAL MARGIN: NO TUMOR SEEN FIBROCYSTIC CHANGES c. ONE LYMPH NODE. LEFT AXILLARY SENTINEL, LYMPHADENECTOMY: NO TUMOR SEEN IN MULTIPLE STEP SECTIONS STAINED WITH ROUTINE AND PANKERATIN IMMUNOCHEMICAL STAINS COMMENT(S) SURGICAL PATHOLOGY CANCER CASE SUMMARY - CAP APPROVED:S Procedure: Excision without wire-guided localization Lymph Node Sampling: Sentinel lymph node(s) Specimen Laterality: Laft Histologic Type of Invasive Carcinoma Invasive ductal carcinoma 1 Tumor Size: Greatest dimension of largest focus of invasion >1. mm: 13 mm Histologic Grade (Nottingham): Glandular/Tubular Differentiation: Score 3 Nuclear Pleomorphism: Score 3 ** CONTINUED ON NEXT PAGE **
+
+--- Page 2 ---
+PAGE 2 RUN DATE RUN TIME: Specimen Inquiry RUN USER: (Continued) SPEC #: PATIENT: COmMEnt(S) (Continued) Mitotic Rate: Score 3 Overall Grade: Grade 3 Tumor Focality: Single focus of invasive carcinoma. Ductal Carcinoma In Situ: No DcIs is prasent Invasive Carcinoma: Margins uninvolved by invasive Margins: carcinoma Distance from closest margin: 2 mm: medial Lymph Nodes: Number of sentinel lymph nodes examined: 1 Total number of lymph nodes examined (sentinel and nonsentinel): 1 Number of lymph nodes with macrometastases (>2 mm): 0 Number of lymph nodes with micrometastases (>0.2 mm to 2 mm and/or >200 cells): 0 Number of lymph nodes with isolated tumor cells (<0.2 mm and <200 cells): 0 Number of lymph nodes without tumor cells. identified: 1 Pathologic Staging: Primary Tumor: pT1b Regional Lymph Nodes: Modifier: (sn) Category: pNo (i-) Distant Metastasis: Not applicable ER: Negative (<1% of tumor cells with nuclear Ancillary Studies: positivity) PR: I Negative (<1% of tumor cells with nuclear positivity) HER2 Immunoperoxidase Studies: Negative (Score 1+) GROSS DESCRIPTION: The specimen is received in the fresh state in three parts for immediate gross evaluation..  This specimen is received for tumor banking and evaluation of the surgical margins and consist of an excision of breast tissue which measures 4 x 4 x 2.5 cm. Present on the. surface is an ellipse of light brown skin measuring 3 x 0.7 cm. The surgeon has tagged the surgical margins. With this as reference. I have inked the margins as follows: Blue is lateral Yellow is inferior Black is medial Red is superior Orange is deep Sectioning reveals a firm, stellate. tan tumor which measures 13 mm in greatest dimension. The tumor focally touches the lateral margin. The next nearest margin is medial at 2 mm. The remaining margins are greater than 1 cm from tumor. A representative section of the tumor is submitted for tumor banking. A recent biopsy site is present in the tumor. ** CONTINUED CN NEXT PAGE ** :
+
+--- Page 3 ---
+RUN DATE: RUN TIME: PAGE 3 Specimen Inquiry RUN USER SPEC #:  PATIENT: (Continued) GROSS DESCRIPTION: (Continued) Representative sections are submitted as blocks A1 through A5 B. This is an excision of breast tissue which measures 2 x 2 x 1 cm. The surgeon has tagged the now lateral margin. I have applied blue ink to this margin. No gross evidence of residual tumor is present in this spscimen. Representative sections are submitted as blocks B1 and B2. C. This is a soft. tan lymph node which measures 15 x 10 x 5 mm. sectioned and totally submitted as block c1 for sentinel node protocol. There is no gross evidence of metastatic 1 tumor. INTRAOPERATIVE CONSULTATION: IMMEDIATE GROSS EVALUATION A (BREAST EXCISION) : FOCAL TUMOR PRESENT AT LATERAL MARGINS WITH REMAINING MARGINS FREE OF TUMOR IMMEDIATE GROSS EVALUATION B (RE-EXCISION LATERAL MARGIN) : NO GROSS EVIDENCE OF TUMOR IMMEDIATE GROSS EVALUATION C (SENTINEL NODE) : NO GROSS EVIDENCE OF TUMOR ! PHOTO DOCUMENTATION Image . Signed (signature on file). ** END OF REPORT * Criteria 3 Dagnosis Discrep Prior Malignancy ilistor ary Notg ISQUALIFIED
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diff --git a/output/text/988b0b4a-939a-4613-b71d-5313ea0afc8f.txt b/output/text/988b0b4a-939a-4613-b71d-5313ea0afc8f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8e10bae973817d4fd22939c15f5975dad19e1003
--- /dev/null
+++ b/output/text/988b0b4a-939a-4613-b71d-5313ea0afc8f.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis/ diagnoses: Colon and rectosigmoid resection material show an ulcerated colon carcinoma. characterized histologically as a moderately differentiated colorectal adenocarcinoma, extending to within 3.5 cm of a resection margin, probably the aboral resection margin encircling the colon wall at a length of 6 cm. Invasive tumor spread tumor within all intestinal wall layers to the bordering mesocolic fatty tissue. The oral and aboral resection margin is tumor-free. Thirty-three mesocolic lymph nodes are tumor-free with. uncharacteristic reactive lesions. Tumor stage: pT3 pN0 (0/33) L0 V0; G2.
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diff --git a/output/text/988dc61b-ce21-4628-ad43-f24a3d477171.txt b/output/text/988dc61b-ce21-4628-ad43-f24a3d477171.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7f43730b1be4d112367841b62fd74bee31fc1db7
--- /dev/null
+++ b/output/text/988dc61b-ce21-4628-ad43-f24a3d477171.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:591638D6-41E8-4489-81F0-0364844478860 TCGA-AN-A0F-01A-PR Redacted TSS Patient ID Case #: DOB: jex: Female Ethnicity (Race): Cancer Sample Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma. Date of Procurement Anatomic Site: Left Breast Tumor location: Primary. Tissue Specification: Tumor Specinen Matrix: Tissue Specimen Format: OCT Container: block Type of Procurement: surgery Grade: 2 T Stage: 2 N Stage: 1 M Stage: 1 Treatment: none. Treatment Details: n/a Normal Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw. Matrix: Blood Specimen Format: frozen Container: tube Date of Procurement 1cs-0-3 corcuiomn mfiHtraHny duct,Nv5 85oo/3 Sit: brast,Nos  c50.9 lw 10 /21  3 jof21/#
\ No newline at end of file
diff --git a/output/text/98a2e5e6-0b04-466e-bb97-f3ade9672300.txt b/output/text/98a2e5e6-0b04-466e-bb97-f3ade9672300.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5f6278ef3726a9553dea78dc9d5d836f4f0a3f59
--- /dev/null
+++ b/output/text/98a2e5e6-0b04-466e-bb97-f3ade9672300.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:6F3784B2-4A75-447C-9EAE-F146461C737E 'Redacted 1cs-0-3 GA-A7-A13D-01A-PR Careint-bnfiItnhing buct, nOs 8.50013 S+fx; Srssot,Nos c5v.9 SPECIMEN A. Sentinel node #1 (84) hot and blue right axilla B. Sentinel node #2 (237) hot and blue right axilla C. Sentinel node #3 (277) hot and blue right axilla. D. Segmental mastectomy right breast single suture lateral, double long anterior E. Superior wall segmental wall right breast; stitch at new superior margin Posterior wall segmental mastectomy right breast; stitch at new posterior margin  Retroareolar mass right breast. H. Sentinel node #4 (300) hot and blue right axilla. CLINICAL NOTES Right breast cancer FROZEN SECTION DIAGNOSIS A. Sentinel node #l, right axilla:. One benign lymph node (0/1). B. Sentinel node #2, right axilla:. Cne negative lymph node (0/1). C. Sentinel node #3, right axilla:. One negative lymph node (0/1). H. Sentinel node #4, right axilla: Benign (0/1). GROSS DESCRIPTION A. Received unfixed for frozen section, labeled "sentinel node #1 hot and blue 84 right axilla" is a l.4 x 1.1 x 0.6 cm lymph node, bisected and entirely submitted in two blocks.. B. Received unfixed for frozen section, labeled "sentinel node #2 (237) hot and blue right axilla", is a 1 x 0.8 x 0.6 cm lymph node, bisected and entirely submitted in one block. C. Received unfixed for frozen section, labeled "sentinel GROSS DESCRIPTION node #3 (277) hot and blue right axilla," is a lymph node that is 3.5 x 3 x 2 cm quadrisected and entirely submitted in four blocks. D. Received unfixed for tissue procurement, labeled "segmental mastectomy right breast", is a portion of. fibroadipose tissue that is oriented with sutures as previously stated, and 8 cm. from medial to lateral, 5.4 cm. from anterior to posterior, and 4.0 cm. from superior to inferior. A mass lesion is identified, 3 x 2.5 x 2.4 cm., a portion of which is submitted for tissue procurement. Margins are inked: superior black, anterior green, inferior yellow, posterior blue. The mass lesion is 2 mm. from the black superior inked margin, and possible less than 1 mm. from the yellow inferior margin. Representative sections are submitted sequentially from lateral to medial, with D1 being the lateral margin, D2-d4 being representative sections between lateral margin and beginning of mass lesion, including representative deep
+
+--- Page 2 ---
+margin and debris of prior biopsy site, with D15 being medial shaved margins. A total 15 cassettes. Rs15.. E. Received fresh subsequently fixed in formalin labeled. "superior wall right breast" is a 4.5 x 3.0 x 1.2 cm.. yellow lobular fatty tissue fragment which has a suture designating a new superior margin. The surface is inked blue. The specimen is sectioned to show no other discrete gross lesions identified and the yellow lobular fatty cut surface. The specimen is entirely. submitted in 6 cassettes. As-6. F. Received fresh subsequently fixed in formalin labeled "posterior wall right breast" is a 1.7 x 1.6 x 1.0 cm.. pink yellow rubbery tissue fragment which has a suture designated to the new posterior margin. This is located on skeletal muscle. The surface is inked blue. The opposite surface is yellow, pink and fatty. No residual tumor is grossly identified. The specimen is sectioned and entirely submitted in one cassette. As-1. G. Received fresh subsequently fixed in formalin labeled GROSS DESCRIPTION "retroareolar" is a white pink rubbery nodule which shows gross evidence of bluing staining present. The specimen is 2.5 x 2.2 x 1.7 cm., having a single suture designating lateral and double suture designating anterior. The specimen is inked as follows: Superior orange, anterior blue, posterior black, inferior green. The specimen is sectioned from medial to lateral to show a white tan whorled cut surface, shows white rice like pellets located in the inferior aspect of the specimen. The specimen is entirely submitted from medial to lateral labeled "1-5". As-5. MICROSCOPIC DESCRIPTION Invasive Carcinoma: Histologic type: Ductal Histologic grade: III Overall grade: 9/9 Architectural score: 3 Nuclear score: 3 Mitotic score:. 3 Greatest dimension (pT2): 3.0 cm. Specimen margins: invasive carcinoma is close to the margins in. the main resection specimen (part D): 1.5 mm from inferior margin, 1 mm from posterior margin, and 1 mm from anterior. margin. Additional margin specimens (superior wall, posterior wall) are negative for carcinoma..
+
+--- Page 3 ---
+Vessel invasion: Not identified Calcification: present Necrosis: present Ductal carcinoma in situ: Histologic pattern: Solid Nuclear grade: 3 MICROSCOPIC DESCRIPTION Central necrosis: Present % Dcis of total tumor (if mixed): <1% Extensive intraductal component: absent Specimen margins: Negative Calcification: Present Description of non-tumorous breast:. Fibroadenoma (part G, retroareolar) Comments: Changes of prior biopsy identified (parts D, G). Prognostic markers: See core biopsy report, 4x7, 3, 14x4, 15x4 DIAGNOSIS A. Sentinel lymph node #l, right axilla, biopsy: Cne negative lymph node (0/1). B. Sentinel lymph node #2, right axilla, biopsy: One negative lymph node (0/1). C. Sentinel lymph node #3, right axilla, biopsy: One negative lymph node (0/1). D. Breast, right, segmental resection: Invasive ductal carcinoma, grade III, close to excisional margins. E. Breast, superior wall, new margin: Negative for carcinoma. F. Breast and muscle tissue, posterior wall, new margin: Negative for carcinoma. G. Breast, right retroareolar, biopsy:. Fibroadenoma. H. Sentinel lymph node #4, right axilla, biopsy: One negative lymph node (0/l). DIAGNOSIS (Electronic Signature) .riteria
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diff --git a/output/text/98b8231e-525b-42e5-83da-de1885cd845a.txt b/output/text/98b8231e-525b-42e5-83da-de1885cd845a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..526de771cf46c48a18b8a76454dd1512f93b255c
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Carcnoma, nifiltrating sluctal nos. 8.500f3 Sitsbraot Nos C50.9 -urgical Pathology: Final Surg Path CLINICAL HISTORY: Large left breast cA with microcalcification diffusely around invasive tumor. Suggests diffuse intraductal carcinoma. GROSS EXAMINATION: A. "Left breast mass (Afl)". Received is a breast biopsy specimen and frozen section remnant..  The breast tissue measures 5.0 x 4.0 x 3.5 cm. The surgeon states that the margin is not important, thus the specimen is not inked. Sectioning of the specimen reveals a red-brown nodule measuring 3.0 x 2.5 x 1.5 cm. Tissue from the nodule has been sent for ER/pR study. A remnant of frozen section of the red-brown tissue measuring 1.7 x 1.3 x 0.3 cm is submitted in toto in Block Al, with representative sections of the nodule submitted in Blocks A2-A4. B. "Left breast", fresh. An 18 x 25 x 6 cm breast mastectomy specimen with a. 23 x 14 cm skin ellipse and a 12 x 9.5 cm axillary tail. The skin ellipse is notable for a grossly unremarkable nipple and areola and a. 5.5 cm recently dehised biopsy scar located in the lower medial portion of the ellipse. The deep surface of the breast specimen is inked in black. Cut sectioning through the breast reveals a 5 x 4 x 4 cm hollow biopsy cavity in the lower medial quadrant which is lined by smooth white tissue in its cavity. The cavity comes to within 0.5 cm of the inked distal surface, 0.8 cm from the inked posterior surface, and 12 cm from the inked proximal surface. There is a focal 1.5 x 1.5 x 1 cm firm, finely granular, grey-pink lesion located adjacent to the lateral tip of the biopsy cavity. This lesion is, at its closest points, 1.5 cm from the distal inked surface, 4 cm from the posterior. inked surface, 4 cm from the posterior inked surface, 11 cm from the proximal. breast specimen is comprised of yellow-white fibrofatty tissue with an especially prominent white fibrous focus in the upper midportion of breast parenchyma. BLOCK SUMMARY:S B1 representative section of nipple. B2-b5 tissue around biopsy cavity site which includes firm lesion described above. B6-B7  representative sections from focal white fibrous area in upper mid-portion of breast.. B8-b9 representative sections of upper medial portion of breast. Bl0-Bli representative sections of lower medial portion of breast. B12-B13 representative sections of upper lateral portion of breast. B14-B15 representative sections of lower lateral portion of breast. B16 three lymph node candidates from intermediate portion of axillary tail.. B17 four lymph node candidates from intermediate portion of axillary tail. B18 five lymph node candidates from most lateral portion of axillary tail. B19 four lymph node candidates from most lateral portion of axillary tail. B20 three lymph node candidates from most lateral portion of axillary tail. Dr. INTRA OPERATIVE CONSULTATION: Afl: "Left breast mass": Infiltrating carcinoma present DIAGNOSIS: A. "LEFT BREAST MASS": UUID: 29811BAC-AFD1-4951-BDF8-78859941B634 TCGA-B6-A0X5-01A-PR Redacted 1 of2
+
+--- Page 2 ---
+BREAST WITH INFILTRATING DUCTAL CARCINOMA (3 X 2.5 X 1.5 CM), NUCLEAR GRADE WELL-DIFFERENTIATED, N.S.A.B.P. HISTOLOGY GRADE 1 OF 3, WITH CANCERIZATION OF LOBULES AND CRIBRIFORM CARCINOMA IN SITU. "LEFT . BREAST": B. BREAST WITH RESIDUAL INFILTRATING DUCTAL) CARCINOMA (1.5 X 1.5 X 1 CM), WITH NUCLEAR GRADE WELL-DIFFERENTIATED AND N.S.A.B.P. HISTOLOGIC GRADE 1 OF 3.  THERE IS A COMPONENT OF COLLOID CARCINOMA REPRESENTING LESS THAN 25% OF THE TOTAL TUMOR VOLUME. THREE OF FOURTEEN (3/14) AXILLARY LYMPH NODES CONTAINING METASTATIC CARCINOMA. LARGEST METASTATIC FOCUS MEASURES 1.8 X 1.1 CM; NO EXTRANODAL EXTENSION IDENTIFIED. ALL SURGICAL MARGINS FREE OF TUMOR. SKIN, NIPPLE AND LACTIFEROUS DUCT; NO TUMOR PRESENT.S Verified by: Date Signed: 2 of 2
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diff --git a/output/text/98be6cd2-39f1-476f-9401-c132b53ea2bd.txt b/output/text/98be6cd2-39f1-476f-9401-c132b53ea2bd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f6093057852402f6248f6e0bf95877c41366236c
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+TOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: FMP/SSN: Specimen #: DOB/Age/Sex: Location: Race: WHITE Taken: Physician(s) : Received: Reported: /cs-0-3 * * AMENDED* * Corunitma, nifi1tnathg ductal nos SPECIMEN: A: LEFT BREAST TISSUE B: SENTINEL NODE LEFT AXILLARY 8500/3 Sit. brest, Nos c5o.9 FINAL DIAGNOSIS: A. BREAST, LEFT, EXCISIONAL BIOPSY: INFILTRATING DUCTAL CARCINOMA, NO SPECIAL TYPE. -NOTTINGHAM GRADE: III/III, POORLY DIFFERENTIATED. -NOTTINGHAM SCORE: 8/9 (TUBULES=3, MITOSES=2, NUCLEI=3). -TUMOR SIZE: 3.1 CM (MEASURED GROSSLY, SEE COMMENT). -TUMOR NECROSIS: ABSENT. -MICROCALCIFICATIONS : ABSENT. -LYMPHVASCULAR INVASION: NO UNEQUIVOCAL INVOLVEMENT. -MARGINS: NEGATIVE. -INTRADUCTAL COMPONENT: LESS THAN 25%, WITH PROMINENT CANCERIZATION OF THE LOBULES (SEE COMMENT). -LYMPH NODES: TWO NODES NEGATIVE FOR TUMOR (ONE SENTINEL, ONE WITH THE BREAST BIOPSY ITSELF, SEE COMMENT). -MULTICENTRICITY: ABSENT. -ESTROGEN RECEPTORS: POSITIVE (>1O%). -PROGESTERONE RECEPTORS: NEGATIVE. -HER 2 NEU BY IHC: POSITIVE (3+). -PATHOLOGIC STAGE: pT2 NO MX. -AJCC STAGE: IN THE ABSENCE OF METASTASES: IIA. B. SENTINEL LYMPH NODE, LEFT AXILLARY, EXCISION: -ONE LYMPH NODE NEGATIVE FOR MALIGNANCY. -IMMUNOHISTOCHEMICAL MARKER FOR CYTOKERATIN CONFIRMS THIS NODE IS NEGATIVE FOR MALIGNANCY. COMMENT : The tumor, measured grossly, is 3.1 cm in greatest dimension. However there is cancerization of the lobules which extends up to 1.5 cm beyond the grossly recognizable mass of invasive tumor. ER,pR and Her 2 studies were performed on the previous core biopsy, the results are copied into this report, but these studies. lave not been repeated. UUID: 28AFD5DD-3607-4837-819F-688C9218ED06 TCGA-A2-A0CX-01A-PR Redacted Page 1 Continued on Next Page PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 2 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: FINAL DIAGNOSIS (continued): Two lymph nodes are identified, both negative for malignancy. One lymph node is present in the breast parenchyma and is the nodule identified grossly near the inferior margin. The second one is the sentinel node in specimen "B". This case has undergone intradepartmental review and the above diagnosis has been agreed upon. ** Report Electronicallv Signed Out ** CLINICAL DIAGNOSIS AND HISTORY: year old white female with left breast cancer GROSS DESCRIPTION: A. Received fresh labeled with patient's name "LEFT BREAST LONG STITCH LATERAL, DOUBLE STITCH DEEP, SHORT STITCH designated superioR" is a 230 gram irregular portion of breast tissue oriented as follows: short suture superior, long lateral and double deep. The specimen measures 1.0 cm medial to lateral, 10.5 cm superior to inferior, and 5.0 cm anterior to posterior and is inked as follows: superior blue, inferior green, lateral yellow, medial red, anterior orange,. posterior black. Serial sectioning reveals a 2.7 x 3.1 x 2.5 cm centrally located pink white firm gritty mass with well defined borders and comes closest to the anterior margin (1.0 cm). A second well circumscribed tan white fibrous mass is noted at the inferior margin measuring 1.1 x 0.9 x approximately 0.8 cm and comes to within approximately 0.4 cm of the inferior green margin and comes to within 0.2  cm of the lateral yellow margin. This mass is located approximately 1.2 cm from the larger mass. Remainder of cut surface is composed primarily of lobulated adipose tissue admixed with scant fibrous tissue. No additional lesions identified. Representative sections submitted as follows: Al: mass and adjacent normal A2: mass and adjacent normal A3: normal, 1.0 cm from mass Matched sections of A1-A3 and fresh/frozen tumor submitted for CBcp protocol. Additional sections A4- A5 inferior margin Page 2 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 Continued on Next Page.
+
+--- Page 3 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: A Specimen #: GROSS DESCRIPTION (continued): A6-A8 small nodule inferior margin A9-Al0: tissue from same plane sectioned in A2. All: next plane of tissue. A12-Al4: tissue from same plane as Al. Al5: superior margin. 15cF. B. Received fresh labeled with patient's name. "SENTINEL LYMPH NODE LEFT AXILLARY" cOnsists of a single 1.0 x 0.8 x 0.4 cm pink tan lymph node with attached adipose tissue. Specimen is bisected designated and~one half submitted in B1 and remaining half submitted for cBcp protocol. Page 3 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974S End of Report.
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diff --git a/output/text/98c67db9-b66d-481a-973a-a91eb5374862.txt b/output/text/98c67db9-b66d-481a-973a-a91eb5374862.txt
new file mode 100644
index 0000000000000000000000000000000000000000..cd7f72ee23fa7b83c3098e6f05793f58d2301200
--- /dev/null
+++ b/output/text/98c67db9-b66d-481a-973a-a91eb5374862.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+tcd-o ~3 Corcwona, adrenal corteca! UUID:4917D13C-6355-4E4B-8189-FE4443313F53 C -OR-A5LK-01A-PR Redacted w/oncocy ticteatures 8370/3 Site :BAdr@o) Ghud cortex 074 Procedure: Right adrenalectomy 9tO q/v/3 Gross Description: Tumor is 244g; measuring 8.2 x 7.5 x 6.5cm.. Diagnosis: Adrenal cortical carcinoma with oncocytic features. Weiss score = 5.
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diff --git a/output/text/98cd93f2-b0a2-4e21-ad1e-6f89d1399319.txt b/output/text/98cd93f2-b0a2-4e21-ad1e-6f89d1399319.txt
new file mode 100644
index 0000000000000000000000000000000000000000..57b28df203f655ef2d92a8215ca7468db99ddaf8
--- /dev/null
+++ b/output/text/98cd93f2-b0a2-4e21-ad1e-6f89d1399319.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+DREVIOUS DIAGNOSIS INQUIRY UUID:6F548B5E-C4A2-46C7-8856-7DD037CC49B5 PAGE#: TCGA-OR-A53X-01A-PR Redacted SEX: M ADM DATE: OPER DATE: PROCEDURE: SPHS History: Left adrenal tumor. Hyeprtension, current smoker.. Source of Specimen: Mesenteric implant. Left adrenal cancer.. Operative Procedure/Tissue Submitted: Left adrenalectomy.. PROCEDURE: SPGD 1. "Mesenteric implant." A 0.1 cm bit. Frozen section control. 2. "Left renal vein lvmoh node." A 1.5 cm lymph node with a fleshy cut Surface. Bisected. Frozen section control. 3. "Left adrenal gland. One long stitch medial, two long stitches anterior, arc(noi two short stitches adrenal vein." Received in formalin in a large container is a 10.5 x 10.5 x 6.0 cm, oriented adrenal gland weighing 445 gm (untrimmed weight). The specimen is inked as fotlows: Anterior - yellow, posterior IC black, superior - blue, inferior - green, medial - red and lateral - orange. Specimen is sectioned to reveal a 10.0 x 8.0 x 6.0 cm, encapsulated mass. The ma Ds 3 tumor is friable and largely necrotic and grossly appears to abut all margins. 3A. Renal vein margin and tumor just distal. 38. Tumor to medial margin.. 3c. Tumor to anterior margin.. 3D. Tumor to posterior. 3E. Tumor to inferior. 3F. Tumor to lateral and tumor to superior.. 3G-H. Additional representative sections of central tunor.. 31. Normal adrenal gland. 3 ADD 1-10. Tumor. corticaf 4. "Retroperitoneal fat." Received in formalin in a small container is a 7 x 6 x 1.5 cm irregular portion of hemorrhagic yellow adipose that is partially encapsulated. Cut surface is a yellow lobular adipose with no lesions identitied. 4A-C. Adipose. 5. "Left perirenal tissue." Received in formalin in a small container is a 5 x C 74frO 8376! 5 x 2 cm aggregate of pink-yellow fibroadipose tissue that is partiatly encapsulated. Focal areas of hemorrhage are identified. Cut surface is unremarkable. 5A-C. Adipose. W FROZEN SECTION REPORT 1. Inflamed fibrotic tissue, favor fat necrosis.. 2. Negative for carcinoma.. have reviewed and interpreted the frozen section material at the time it was requested..
+
+--- Page 2 ---
+PREVIOUS DIAGNOSIS INQUIRY REPORT DATE: PAGE#: SEx:M BIRTHDATE: PAT TYPE: ADM DATE: OPER DATE: Permanent sections confirm frozen section report.. PROCEDURE: SPMI ADRENOCORTICAL CARCINOMA Tumor Size: 10 x 8 x 6 cm Tumor Weight: 445 gm Capsular Invasion: Yes Vascular Invasion: Yes (adrenal vein) Surgical Margins: Negative Necrosis: Yes, focal Mitotic Rate: 5 mitoses / 50 hpf Grade: Low Extra-adrenal Extension: Yes, adrenal vein Stage: 111 Immunohsitochemistry resul ts: alpha-inhibin  Positive Mel an-A Positive PROCEDURE:SPDX 3. Left adrenal gland, resection: Adrenocortical carcinoma, low-grade by mitotic activity, with invasion of adrenal vein. See Template. free. 1. Mesenteric implant, excision: Benign mesenteric cyst with chronic infl ammation, negative for neoplasm. 2. Left renal vein lymph node, resection: One lymph node, negative for neoplasm. 4-5. Retroperitoneal fat, left perirenal tissue, resection: Benign. fibroadipose tissue, negative for neoplasm.. 120
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diff --git a/output/text/98d8cb86-a6a9-47f9-aeff-39af9a6adb1c.txt b/output/text/98d8cb86-a6a9-47f9-aeff-39af9a6adb1c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5eef297055e572f00303e092bad0653221ee6060
--- /dev/null
+++ b/output/text/98d8cb86-a6a9-47f9-aeff-39af9a6adb1c.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+/cs0-3 Cortin0mh,infi/trstinf duc#l, Nos 85oo/3 7oH Site brst,uoQ C5o.4 /35 Diagnosis: Poorly differentiated invasive ductal carcinoma (tumor diameter: 2.8 cm) Concluding tumor classification: NOS, G III, pT2N1aL0V0R0. (compare E. no. xxxx) UUID: B687939C-63AF-4B52-B494-AA09A9C03871 Redacted
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diff --git a/output/text/99124dc5-b607-4c8f-acbc-64f7b92e529b.txt b/output/text/99124dc5-b607-4c8f-acbc-64f7b92e529b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e20607f764a30fcaee407dba448a1b900d80a49d
--- /dev/null
+++ b/output/text/99124dc5-b607-4c8f-acbc-64f7b92e529b.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis (diagnoses): Resected colon sample with a centrally ulcerated, moderately differentiated  adenocarcinoma of the colorectal type, measuring a max of 4.8 cm in diameter, with broad infiltration of the pericolic fatty tissue and two local lymph node metastases immediately next to the tumor. Tumor-free colon resection margins. Tumor-free mesenteric resection margin. Otherwise, individual tubular adenomas of the colon mucous membrane with predominant moderate dysplasia (synonym: mild intraepithelial neoplasia). The tumor stage is: pT2, pN0 (0/27) pMX; G2, L0, V0, R0
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diff --git a/output/text/992f6ce7-6d69-40af-b917-b18dc3728715.txt b/output/text/992f6ce7-6d69-40af-b917-b18dc3728715.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c7b420ee815c0295afb77e4a547a23d4896e5331
--- /dev/null
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+1CD-0-3 adenocsrtioma N0s 814o/3 S:tx: Qscndiiq Co1on C18.s 2|10fm j UUID:9E26E5F5-0FD1-4045-87F6-3C1362F5DF84 Redacted TCGA-DM-A1HA-01A-PR (First Tumor) Tumor Site: Ascending Colon Date of Cancer Sample Procurement: Histology: Adenocarcinoma 3 Description of other histology: Grade: Poorly Differentiated Mucinous: C Yes 6 No C Yes C Unknown (Focal) Signet Ring Feature: ^Yes  No  Yes c: Unknown (Focal) Histologic Heterogeneity: C No  Yes ^ Unknown Host Response: None Crohn's like reaction.  None C Yes C Unknown Plasma cell rich stroma C No C Yes C Unknown Growth Pattern: C Expansile  Expansile ^ Invasive  Unknown  and Invasive Inflammatory Bowel Disease 6 No C Yes C Unknown Angiolymphatic Invasion: C No  Yes C Unknown Mutator Phenotype: C No  Yes C Unknown Number of Slides 1 Garland Necrosis present: ( Yes C No C Yes c Unknown (Focal) TIL Cells / HPF Pathologist Comment: deep edge of tumor not s..
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diff --git a/output/text/9978097d-a0b2-41de-bbbe-4306f549161d.txt b/output/text/9978097d-a0b2-41de-bbbe-4306f549161d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3774d8a6bf65f522d2f02145cfbff2368ffa1980
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:B41B7C44-ED04-46EB-AD41-271456ECA762 CG AACK-01A-PR Redacted CLINICAL DIAGNOSIS: HCC Specimen : Liver Gross Photo :. GROSS: 1. Specimen: Liver: 10.0 x 9.5 x 5.5 cm, 169.5gm, unfixed IcD6-3 8.0 x 6.0 x 5.2 cm, 66.0 gm, unfixed Corsenoma, hepstoullelar Nt3 2. Tumor location: right Tumor number: One 8170/3 Tumor size: 5.3 x 4.9 x 5.5 cm Site: oluer Cx3.O 3. Satellite nodule: no 4. Gross type V>5/19|14 HCC: expanding nodular 5. Tumor necrosis: no 6. Hemorrhage/peliosis: yes (5-10 %) 7. Portal vein invasion: no 8. Bile duct invasion: no Gross photo present. Blocks TB, T1-5, tumor mass x 6 NB, A, non-tumorous tissue x 2. RM, resection margin x 1 MICROSCOPIC: 1. Hepatocellular carcinoma: 1-1. Differentiation The worst differentiation II The major differentiation II 1-2. Histologic type: trabecular 1-3. Cell type: clear 1-4. Fatty change: no 2. Fibrous capsule formation: complete capsule 3. Capsular infiltration: no 4. Septum formation: yes 5. Surgical resection margin invasion: no, margin of the clearence (3.0 mm) 6. Serosal invasion: no 7. Portal vein invasion: no
+
+--- Page 2 ---
+8. Bile duct invasion: no. 9. Hepatic vein invasion: no. 10. Hepatic artery invasion: no. 11. Microvessel invasion: yes. 12. Intrahepatic metastasis: no 13. Multicentric occurrence: no. NOT reported. Gross: Urine, smear, negative. Urine, smear, negative Urine, smear, negative. Liver, ectomy, hepatocellular carcinoma, cirrhosis T56000, P10, M81703, M49500 DIAGNOSIS: Liver, right lobe, lobectomy: Hepatocellular carcinoma, well differentiated Cirrhosis Suggestion : bw 1|131'y Case is (circle
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diff --git a/output/text/998a527a-fe37-4f1d-abe7-deeb1bbc79bd.txt b/output/text/998a527a-fe37-4f1d-abe7-deeb1bbc79bd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4d141e042dd584598fb24d97d2047712eb1631f5
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+Surg Path Final Report * Final Report * Result Type: Sura Path Final Report Result Date: Result Status: Result Title: Surgical Pathology Final Report Verified By: Encounter info: Final Diagnosis (Verified) Distal left ureter, frozen section examination, excision:. Negative for neoplasm.s. Distal right ureter, frozen section examination, excision: Negative for neoplasm. Additional prostatic apical tissue: Benign prostatic glandular tissue with scattered areas of squamous metaplasia involving the duct lumen, no invasive malignancy identified.. Radical cystoprostatectomy: Infiltrating high-grade urothelial carcinoma with diffuse squamous inked differentiation extending through entire bladder muscular wall and to radial margin of surgical excision. Bladder tumor measures 5.5 cm in maximum dimension and is positioned on the posterior bladder wall. Marked necrosis is present.. Prostate is negative for malignancy.. Seminal vessicles are negative. /es-0-3 Left lymph node dissection:. Seven (7) negative lymph nodes. Chucinoma, irotheliul Nos 81x0/3 Site: b1odsi Nos C679 Right lymph node dissection: 12/2fr h Four (4) negative lymph nodes. UUID:FFC0F91A-AC95-4E02-BE22-EBDAE89AB5EA Redacted Page 1 of 3 Printed by: TCGA-GC-A3I6-01A-PR (Continued) Printed on:
+
+--- Page 2 ---
+Surg Path Final Report * Final Report * Comment: This large, partially necrotic, diffusely infiltrating, high-grade transitional cell. carcinoma shows diffuse areas of squamous differentiation. The tumor extends to the inked. radial margin of excision. This case corresponds to a pathological AJCC stage of T3a,N0 Signature Line (Electronically signed by) Verified on: Gross Description (Verifled) "FSA." All frozen section control tissue is submitted in cassette "FsA,". "FSB." All frozen section control tissue is submitted in cassette "FsB,". "C, Additional apical tissue." The speclmen consists of 3 unoriented soft gray-pink fragments ranging in size from 1.6 x 1.6 x 0.7 cm to 2.4 x. 1 x 0.8 cm. Inked black. "C1-C2, fragments, representative. "D, Sladder." The specimen conslsts of an 11.8 x 9.5 x 8.6 cm bladder with attached fat. Attached is the prostate gland. Bilateral dista!  ureters have previously been submitted for frozen section. The specimen ls opened on the anterlor aspect and there is a 5.5 x 3.5 cm soft red-tan friable ulcerated mass on the posterior bladder wall which extends to the right aspect of the bladder. The mass grossly appears to. extend into the bladder musculature to a depth of 2.5 cm and grossly Iy appears to abut the radial margin. The radial margin has been inked black. The mass does not grossly appear to involve the left and right ureteral orifices. The remaining bladder mucosa is red-tan and. are grossly identified in the bladder. The attached prostate gland measures 4.2 x 4 x 1.8 cm. The posterior apex will be inked orange. The remaining prostate is inked black their junctlon with the prostate. The prostatic parenchyma is tan and no discrete yellow masses are grossly identified. "D1," distal urethral "D6," mass; "D7." teft bladder mucosa; "D8." bladder dome; "D9." right bladder mucosa; "D10," trigone; "D11," left seminal vesicle and vas deferens; "D12," right seminal vesicle and vas deferens; "D13," ieft anterior prostate; "D14," right anterior prostate; "D15," left posterior prostate; "D16,* right posterior prostate. "E, Left lymph node." The specimen consists of a 3.6 x 3.6 x 2 cm aggregate of yeliow lobulated tissue. On sectioning, 7 possible lymph nodes are identified. These range in size from 0.3 to 1.5 cm. "E1-E3," fragments, representative.. "F, Right lymph node." The specimen consists of a 4.4 x 3.2 x 1.5 cm aggregate of yellow iobulated tissue. On sectioning, 4 possible lymph. nodes are Identified. These range in size from 0.4 to 1.8 cm. "F1-F2." fragments, representative.. Printed by: Page 2 of 3 Printed on: (Continued)
+
+--- Page 3 ---
+Surg Path Final Report * Final Report *.  Received for research purposes is 1 yellow cassette labeled " Slanature Line. Frozen Section Diagnosis (Verified) FSA: Distal left ureter: No tumor noted. FSB: Distal right ureter: No tumor noted. Clinical Information (Verified) This : -year-old white male is a patient with spina bifida who has been on lifelong intermittent catheterizations. The patient has a long history of smoking (3 to 4 packs a day). Completed Action List: * Order by * VER!FY by * Order by Page 3 of 3 Printed by: (End of Report). Printed on:
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diff --git a/output/text/99b1626b-81fa-4f75-bbe8-d747525a1e9d.txt b/output/text/99b1626b-81fa-4f75-bbe8-d747525a1e9d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f0dd253e8fed42351e1ee3aef3a92a9bd60ce0e4
--- /dev/null
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+--- Page 1 ---
+UUID:F0CF61C8-9797-4AF1-A206-0AFA8E361046 TCGA-VD-AA8S-01A-PR Redacted Department of Pathology  HISTOPATHOLOGY  Lab No Surname Clinical Consultant & Location Forenamo(s)  DOB/Age  Sex Unit No  Request Date This Copy For: SPECIMEN RIGHT ENUCLEATED GLOBE, PROGNOSTIC AND DIAGNOSTIC TESTS CLINICAL DETAILS Right eye choroidal melanoma,.. involved optic nerve.. Tumour size: 13.36 x 13.42mm (thickness 6.43)mm. MACROSCOPIC DESCRIPTION A fresh, intact, right globe.. Dimensions: Axial 25mm, Horizontal 25mm, Vertical 25mm Cornea: Horizontal 12.4mm, Vertical 12mm. ICD c:3 Optic nerve Length Smm, Diameter 4mm. Pupil: dilated JJ 6/3t/1y On trans-illumination, a shadow is seen posteriorly in the infero medial quadrant 12mm, query involvement of the disc. Plane of section: vertical. Intraocular description:. On opening, a solitary, dome shaped, pigmented tumour is seen involving the optic disc. Cut surface of optic nerve is dusky - ? infiltration with tumour.. Tumour size LBD 13mm, Height 6mm. MICROSCOPY Histologically, the enucleated eye demonstrates a normal anterior segment with an unremarkable cornea, a deep. anterior chamber and open angles. The iris leaves are unremarkable. The ciliary muscles are moderately atrophic. lens shows moderately advanced cataractous changes. Reported: Pathologist: Electronically Verified:
+
+--- Page 2 ---
+rinted: Department of Pathology Page 2 of 3 HISTOPATHOLOGY REPORT Tel:  Surname Lab No Clincal Consultant & Location Forename(s) DOB/Age Sex Unit No Request Date This Copy For: In the posterior segment, close to the optic nerve head, a choroidal melanoma can be seen. This is dome-shaped with a small accompanying exudative retinal detachment. The retina. overlying the tumour is atrophic with degenerative changes.. Focaliy, at the apex of the tumour, there is retinal invasion. The tumour is partially pigmented and consists predominantly of spindle cells. The melanoma cells are immunoreactive for MelanA, CD1l7 and HSp-27 (score 3). The number of mitoses is approx. 2/40 high power fields. The microvasculature of the melanoma is not prominent, and closed loops are not present in the tissue planes evaluated. Occasional  "vascular lakes" can be observed; in these tumour cells can be see located within the lumen. The lymphocytic. infiltrate within tumour is minimal. Macrophages are. scattered throughout the tumour in a mild density.There is no evidence of scleral invasion or of extraocular growth. The optic nerve is tumour free,. and demonstrates mild. atrophic changes. The examined vortex veins are free of tumour. FINAL DIAGNOSIS Choroidal melanoma of spindle cell type. COMMENT In the meantime, molecular genetic analysis of tumour DNA extracted from the fresh uveal melanoma tissue was performed using the technique termed multiplex ligation-dependent probe amplification (MLpA). These investigations were. performed in the The kit p027 from  which examines for gains or. losses in 31 loci on chromosomes 1, 3, 6 and 8, was used. The DNA concentration was measured using and the quality assessed using multiplex-pcR prior to the MLPA reaction. Reported: Pathologist: Electronically Verified:.
+
+--- Page 3 ---
+printed: : Department of Pathology. Page 3 of 3 HISTOPATHOLOGY REPORT Tel: Lab No Surname Clinical Consultant & Location Forename(s) DOB/Age Sex Unit No Request Date Thls Copy For: The DNA concentration was high and of good quality on assessment. The MLPA reaction was run at least twice on differing occasions, resulting in similar results. The results of the sequence analysis of the MLpA products is printed on a separate report. In summary. sequence analysis demonstrated: normal chromosome 1, three borderline losses of chromosome 3, gains of chromosome 6. and gains in chromosome 8.. These molecular data require correlation with the clinical and morphological data for metastatic risk assessment. Reported: Pathologist: Electronically Verified: 3/4/1Y
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diff --git a/output/text/99b58ffd-3cb6-4738-9bd3-fc4cec8f00a3.txt b/output/text/99b58ffd-3cb6-4738-9bd3-fc4cec8f00a3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2dad13dfa3f7e14f201e2b516e1f766e79c45a10
--- /dev/null
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+PREVIOUS DIAGNOSIS INQUIRYS UUID: 2D791779-66E6-408C-B479-CC74246F0EA8 TCGA-OR-A5SU-01A-PR Redacted PAGE#: SEX:F PAT TYPE: ADM DATE: OPER DATE: PROCEDURE: APMI ADDENDUM REPORT FOLLOWING IMMUNOHISTOCHEMISTRY: To further evaluate this adrenocortical carcinoma, immunohistochemical stains. for p53, beta-catenin and Ki-67 were performed. Please see diagnosis and comment below. PROCEDURE:APDX 1. Right adrenal gland, resection: Adrenocortical carcinoma, low-grade by mitotic activity. Margins negative. Please see previous report and coMMENT below. COMMENT : This low-grade adrenocortical carcinoma shows a variety of histologic  patterns. A p53 immunostain shows a focal area with nuclear pleomorphism to be. positive for nuclear immunoreactivity within this region, raising the. possibility of an early and focal p53 mutation. The Ki-67 immunostain shows an increased Mi8-1 labeting index within this p53-pasitive region. Throughout the neoplasm, the beta-catenin stain shows a membranous immunoreactive pattern, consistent with the absence of a WNT pathway activation. The p53 and MIB-1. results together raise the possibility that this low-grade adrenocortical carcinoma has developed a focal high-grade component. However, the clinical significance of a focal high-grade component is unknown. - -hg signing statf pathologist, have exaninea ana interpreted the slides from this case. "This test was developed and its performance characteristics determined by the. It has not been. cleared or approved by the U.s. Food and Drug Adninistration. (The FDA has determined that such clearance is not necessary.. This test is used for. clinical purposes. It should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory. Improvement Amendnents of 1988 ("cl1A] as qualified to perform high complexity testing)." ICD-6 3 Carcinomo,odrenal ser Hcog 370/3 Sife! Ad^ual Glend,Csrtex.. C 74. Qe i|3c1i3
+
+--- Page 2 ---
+PREVIOUS DIAGNOSIS INQUIRY REPORT DATE: PAGE#: 2 SEX:F BIRTHDATE: ADM DATE: OPER DATE: OPER DATE: PROCEDURE: SPHS Right adrenal mass and hepatic cyst and cortisol production. Concern for adrenal cortical carcinoma. Operative Procedure: Right adrenalectomy, possible. hepatic cyst removal.. PROCEDURE:SPGD 1. #Right adrenal gland, 2 short stitch = superior, 1 long = lateral, 2 long = posterior, concern for Acc" Received in formalin is a 160 gram, 8.7 cm superior to inferior x 7.7 cm medial to lateral x 4.9 cm anterior to posterior. adrenalectomy specimen that contains an 8.5 x 5.2 x 4.8 cm tumor and a small anount of attached adipose tissue. The tumor appears to arise from the adrenal cortex and has fleshy, tan cut surfaces with bright orange foci. A 4.5 x 4.2 x. 3.9 cm area of the tumor is soft and yellow-white, probably necrotic. The tumor is well-circumscribed and closely approaches all margins but there is. freely mobile capsule at all margins. Single short stitch superior. Single long stitch is lateral. Double long stitch is posterior. Anterior inked yellow, posterior inked black, superior blue, inferior green, medial red, lateral orange. Gross photographs taken. 1A. Tumor to superior margin. 18. Tumor to inferior margin. 1C. Temor to anterior margin. 10. Tumor to posterior margin. 1E. Tumor to lateral margin. 1F-H. Tumor to medial margin with adrenal gland. 1I-J. Additional representative sections of tumor. 2. "Right liver cyst wall" Received in formalin is a 7.4 x 2.7 x 0.4 cm portion of tissue with a pink-tan, smooth surface on one side and a pink-red ragged surface on the other side. No masses or lesions are identified. Two representative sections submitted in cassette 2A. PROCEDURE: SPMI ADRENOCORTICAL CARCINOMA V4
+
+--- Page 3 ---
+PREVIOUS DIAGNOSIS INQUIRY REPORT DATE: PAGE#: SEx:F BIRTHDATE: PAT TYPE: ADM DATE: OPER DATE: Tumor Size: 8.5 x 5.2 x 4.8 cm Tumor Weight: 160 grams Capsular Invasion: Present. Vascular Invasion: Absent Surgical Margins: Negative Necrosis: Present Mitotic Rate: 10 per 50 high-power fields Grade: Low Lymph nodes status: N.A. Extra-adrenal extension: Present. Stage: T3NXMX Immunohistochemistry Results: N/A PROCEDURE: SPDX 1. Right adrenal gland, resection: Adrenal cortical carcinoma (8.5 cm), low-grade. Margins negative. Please see template above for details.. 2. Right liver cyst wall, excision: Simple cyst.. ne signing staff pathologist, have personally. examined and"interpreted the slides from this case..
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diff --git a/output/text/99c0fb0a-5741-4b10-8162-625cdfed755b.txt b/output/text/99c0fb0a-5741-4b10-8162-625cdfed755b.txt
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index 0000000000000000000000000000000000000000..43d2fcac763ce5567ecc4e92098fda81d75690cc
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+ID-O-3 FINAL PATHOLOGIC DIAGNOSIS Arcincmo; duc IaI NoS 8600/3 A. Right breast implant: Sile Breast NoS - Breast implant, gross examination only. C so.9 OtO1Q|i8/i3 B. Right skin sparing mastectomy: - Invasive ductal carcinoma, SBR grade I with satellite lesion, see. parameters. - Ductal carcinoma in-situ, intermediate nuclear grade, solid and cribriform type, with necrosis. - Intraductal papilloma with intraductal hyperplasia, usual type. - Columnar cell changes.. UUID:9536A134-A44C-4698-A525-DEEE7FACD144 - Apocrine metaplasia. TCGA-OL-A5RX-01A-PR Redacted - Intraductal hyperplasia, usual type. - Duct ectasia. - Fibroadenoma. - Focal lactational changes. - Fragments of implant capsule. C. Right breast, submuscular capsule: - No tumor present. - Fibrovascular tissue with hyalinization and reactive change consistent with breast implant capsule.. Breast Pathologic Parameters 1. Invasive carcinoma: A. Gross measurement: 2.0 cm index lesion and 0.7 cm satellite lesion (located 2 cm superior from index mass)
+
+--- Page 2 ---
+B. Composite histologic (modified SBR) grade: I - Architecture: 1 - Nuclear grade: 3 - Mitotic count: 1 C. Associated intraductal carcinoma in situ (DciS): - Within main mass (forming 50% of tumor volume) - Extending away from main mass. 2. Intraductal carcinoma: A. Microscopic measurement: Approximately 4.7 cm (main mass extending to satellite lesion) B. Type: Cribriform, solide C. Nuclear grade: Intermediate D. Associated features: Necrosis, cancerization of lobules 3. Excisional biopsy margins: Free of tumor - DCis > 3 mm from posterior (closest) margin - Invasive carcinoma > 10 mm from posterior (closest) margin. 4. Blood vessel and lymphatic invasion: Not identified 5. Nipple: Unremarkable 6. Skin: Uninvolved 7. Skeletal muscle: Uninvolved (attached small fragment). 8. Axillary lymph nodes: Negative (0/4) 9. Special studies - ER: Strong expression in > 90% of invasive tumor nuclei - PR: Strong expression in >90% of invasive tumor nuclei - Her2/neu antigen (FisH): Non-amplified (ratio: 1.0).
+
+--- Page 3 ---
+10. pTNM (AJCC, 7th edition, 201O): pT1c(m), NO, MX Clinical History: The patient is a  vear-old female with invasive ductal carcinoma, grade 1 undergoing right skin sparing mastectomy.. Specimens Received: A: Right breast implant B: Right skin sparing mastectomy. C: Right breast submuscular capsule Gross Description: The specimens are received in three containers each labeled with the patient's name and medical record number.. A. The first container is additionally identified as, 'right breast implant'. Received is a 12.9 x 12.0 x 0.5 cm deflated breast implant with inscription nith 0.9 x 1.5 x 0.5 cm portion of white soft tissue. Gross photographs are taken. The specimen is for gross only.
+
+--- Page 4 ---
+B. The second container is additionally identified as, 'right skin sparing mastectomy'. Received fresh and placed in formalin is a 724 gm simple skin. sparing mastectomy specimen. The specimen is oriented with a double short suture  designating the superior aspect, a double long suture designating the lateral.  aspect, a single short suture designating the medial aspect, and a single long. suture on the nipple margin. The specimen measures 21 cm from medial to lateral, 18.5 cm from superior to inferior, and 4 cm from anterior to posterior. An. L-shaped piece of skin consists of a brown areola measuring 4.1 cm in diameter with an adjacent piece of brown skin extending laterally measuring 6.5 x 3.5 cm, and an adjacent piece of brown skin extending inferiorly from the areola.  measuring6.1 x 3.0 cm. In the center of the areola is a retracted nipple measuring 0.8 cm in diameter. There is a 4x5 cm area of white smooth and glistening membranous area on the posterior surface consistent with implant. capsule. The specimen is inked as follows: anterior superior - blue; anterior inferior - green; posterior - black. The specimen is serially sectioned from medial to lateral into 16 slices to reveal a white, firm, 2.0 x 1.9 x 1.9 cm mass in slices 9. A clip is identified in slice 9. The mass is 2.5 cm from the posterior margin (black ink) and 1.5 cm from the inferior anterior margin (green ink). There is a 1 cm white firm area (abutting the posterior margin) just superior to the index lesion.
+
+--- Page 5 ---
+There is a 0.7 x 0.7 x 0.6 cm ill-defined white firm area identified in slice 8.. This lesion is 2.6 cm from the posterior margin, more than 2 cm away from all other margins and 2.0 cm superior to the index lesion.. The remainder of the specimen consists of approximately extending onto 45 % dense gray-white fibrous breast parenchyma and 55 % lobulated yellow adipose tissue. No additional masses or nodules are grossly identified.. Block summary:e B1: Nipple, serially sectioned. B2: Areola B3: Closest margins to index lesion B4-5: Index mass, slice 9. B6: Index mass, slice 9, with the white firm area. B7-12: white firm area, slice 8, entirely submitted B13-14: Lower inner quadrant, slice 2 and 4. B15-16: Upper inner quadrant, slice 1 and 3. B17-18: Lower outer quadrant, slice 7 and 10. B19-20 Upper outer quadrant, slice 7 and 11. C. The third container is additionally identified as, 'right breast submuscular. capsule'. Received fresh is a 14.5 x 1.0 x 0.3 cm portion of white and. glistening membranous tissue. A representative section is submitted as C1 yi0/3
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diff --git a/output/text/99d548ff-0786-42d2-8d00-9b10f2d81980.txt b/output/text/99d548ff-0786-42d2-8d00-9b10f2d81980.txt
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index 0000000000000000000000000000000000000000..292be60a61b2f8f1f013468180d4b790ae7b69bb
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+UUID: 3C301346-4594-4071-A754-04F8838E894C TCGA-A7-A2KD-01A-PR Redacted 1cs-0-3 Date Coll: Carcinoma, infittrating duct,nus SURGICAL PATHOLOGY REPORT 8500/3 Sits,brsot,Nos c5o.9 h 8fyJh SPECIMEN A. Right breast tissue long stitch 12 o'clock, short stitch apical node and axillary contents. B. Left breast tissue stitch marks 12 o'clock. CLINICAL NOTES PRE-OP DIAGnosis: Right multifocal invasive breast tumor 9 o'clock and 1 o'clock status post core biopsy. Left breast DcIs 2 O'clock and Lcis at 9 o'clock.. POsr-oP DiAgnosis: Right MRm, left simple mastectomy. GROSS DESCRIPTION A. Received fresh labeled "right breast tissue and. axillary contents" is a 19.0 cm. (medial to lateral) x 16.0 cm. (superior to inferior) x 5.2 cm. (anterior to posterior) soft, lobulated tan gold-white portion of fibroadipose tissue in keeping with breast designated as right per requisition slip and container x 3.0 cm. portion of axillary fat extends from the iateral aspect of the specimen. There is a 12.5 x 6.9 cm. brown portion of skin with an eccentric, everted, 1.5 x 1.5 x 0.5 cm. nipple along the anterior aspect. On section, the nipple appears unremarkable.  The intact deep margin is inked biack and the specimen is sectioned. There is a moderately well circumscribed, 3.8 cm. (superior to inferior) x 3.5 cm. (medial to lateral) x 3.2 cm. (anterior to posterior) inner quadrants. A portion of tumor and a portion of normal. parenchyma are submitted for tissue procurement as requested. tumor is present to within l.5 cm. of the inked deep margin and 1.0 The cm. of the anterior surface of the specimen (subsequently inked blue). Approximately 6.5 cm. lateral to the primary lesion is a second, palpable firm tan white tumor mass measuring 2.0 cm. (medial to lateral) x 1.8 cm. (anterior to posterior) x 1.3 cm. (superior to inferior).  The second lesion is located within the lower outer quadrant. The second tumor extends to within 1.4 cm. of the inked deep margin.  The parenchyma between the two lesions is dense tan four quadrants (see blocks 10 and 11). No additional mass lesion or abnormality is identified. The remaining cut surfaces consist predominantly of glistening lobulated golden yellow adipose tissue with a moderate amount of interspersed tan white fibrous tissue. Located at the apex of the attached axillary dissection is a rubbery  Multiple additional rubbery tan white to tan pink tissues in keeping with lymph nodes measuring up to 5 cm. in greatest dimension are recovered from the remainder of the axillary fat..  The largest node appears in keeping. with a matted lymphoid aggregate with tan white cut surfaces suggestive of metastasis (see representative sections blocks 19 and 20).  Received separately within the specimen container is an additional, ovoid, 2.5 cm. rubbery tan tissue in keeping with lymph node.  Representative sections are submitted in 24 cassettes as. labeled.
+
+--- Page 2 ---
+BLOCk suMMARy: 1 and 2 - large tumor to inked deep margin; 3 and 4 - large tumor to anterior surface (inked blue); 5 and 6 - large tumor to adjacent parenchyma 7 - smaller tumor lower outer quadrant to inked deep margin; 8 and 9 remainder of smaller tumor.. 10 and 1l - parenchyma between the two lesions including presumptive prior core biopsy site; 12 - random upper outer quadrant; 13 - upper inner quadrant; 14 - lower inner quadrant; 15 - lower outer quadrant; 16 - bisected apical node; 17 - three whole lymph nodes; 18 - one bisected lymph node; 19 and 20 - representative from largest (?matted) node, three sections total; 21 and 22 - bisected separately received lymph node (one half per cassette); RR1 nipple; RR2 skin over main tumor.. B. Received fresh labeled "left breast tissue" is a 17.5 cm. (medial to lateral) x 14.8 cm. (superior to inferior) x 4.8 cm. (anterior to posterior) soft, lobulated tan gold-white. portion of fibroadipose tissue in keeping with breast designated as left per requisition slip and container and oriented by suture as stated previously. There is a 9.5 cm. (medial to lateral) x 4.4 cm. (superior to inferior) wrinkled brown skin ellipse with an eccentric, everted, 1.5 x 1.5 x 0.8 cm. nipple along the anterior aspect. Within 1 cm. of the superior skin margin, corresponding to the junction of the upper inner and outer quadrants, is a 7.4 x 4.5 cm. defect which communicates with a subjacent 9.5 cm.. (medial to lateral) x 5.0 cm. (anterior to posterior) x 4.0 cm. (superior to inferior) vacant biopsy cavity (?biopsy cavities). The cavity is oblique traversing the lower inner quadrant, extending to the upper outer. The cavity focally extends to within 0.8 cm. of the inked deep margin at its medial aspect (see blocks 1 and 2). A stellate firm focus measuring 1.0 x 1.0 x 1.0 cm. is identified along the deep margin 3.5 cm. inferior to the medial portion of the cavity (see blocks 3 and 4).  Residual discrete lesion is not identified grossly along the periphery of the cavity. Margins are inked as follows: anterior surface defect orange; inferior black and posterior blue. The remaining cut surfaces consist predominantly of glistening lobulated golden yellow adipose tissue with a scant amount of interspersed delicate tan white fibrous tissue. Representative sections are submitted in 17 cassettes as labeled. BLOCk sumMARy: 1 and 2 - biopsy cavity to closest inked deep margin; 3 and 4 - bisected nodule subjacent to biopsy cavity extending to inked deep margin (one half per cassette); 5 through 12 - representative biopsy cavity to anterior defect and adjacent parenchyma sequentially from medial to lateral; 13 -  random upper outer quadrant; 14 - upper inner quadrant; 15 - lower inner quadrant; 16 - lower outer quadrant; 17 - nipple. MICROSCOPIC DESCRIPTION A.  This modified radial mastectomy specimen contains two foci of invasive ductal carcinoma. The larger is in the mid-medial portion measuring 3.8 cm.. The smaller one is in the. lower outer quadrant, 6.5 cm lateral to the larger tumor. Morphologically, they are quite similar and both of high grade. Between the tumors, lymphovascular space invasion is present without parenchymal invasion. The smaller tumor is also associated with high-grade ductal carcinoma in situ. It is likely, therefore, that these two foci represent separate primaries, even though there remains a possibility that the smaller tumor is metastatic. Please see the template below. The template incorporates the findings on both of the tumors. Invasive carcinoma: Histologic type: Infiltrating ductal carcinoma Histologic grade:  Both tumors are poorly differentiated Overall grade: Elston SBR grade 3 Architectural score: 3
+
+--- Page 3 ---
+Nuclear score: 3 Mitotic score: Greatest dimension (pT): The larger tumor measures 3.8 cm and the smaller measures 2 cm, pT2. Specimen margins: Negative Vessel invasion: Extensive lymphatic invasion present. Calcification: Negative. Nipple (Paget's): Negative for Pagets's. Dermal lymphatic invasion present. Invasion of skin or chest wall: Negative. Ductal carcinoma in situ:  Both tumors are associated with similar high-grade  ductal carcinoma in situ. Histologic pattern:  Cribriform and solid Nuclear grade: 3 Central necrosis: Positive % Dcis of total tumor (if mixed):. DcIs is a minor component. Extensive intraductal component ( (present/absent): Absent Specimen margins: Negative Calcification: Positive Description of non-tumorous breast:  Fibrocystic changes present. including cysts and apocrine metaplasia.  Random sections of the lower inner quadrant and lower outer quadrant disclose lymphatic. invasion. Comments:  In the mid-breast, a biopsy site is noted consistent with prior core biopsy.  This site discloses lymphovascular space invasion. Lymph nodes: Number of positive nodes of total: Eight out of 10 lymph contain metastatic carcinoma, including the apical node, 8/10.. Size of largest metastasis: 1.0 cm. Extracapsular extension (present/absent): Absent pN: pN2a Distant metastasis (pm): Cannot be assessed. Prognostic markers: Previously performed.. B.  This simple mastectomy specimen contains a large biopsy cavity. In the vicinity there is lobular carcinoma in. situ.  No invasive tumor and no ductal carcinoma in situ present..  Fibrocystic changes are noted, including cysts, apocrine metaplasia, florid ductal. hyperplasia and calcifications. The nipple is negative for tumor,. as is the overlying skin. [A few of the antibodies used in our laboratory may be classified as analyte specific reagents.  These antibodies are monitored and controlled in our laboratory and their performance for in vitro diagnosis is well described in the medical literature. They have not been cleared or approved by the FDA.]
+
+--- Page 4 ---
+DIAGNOSIS  Right breast, modified radical mastectomy - A. Two foci (multifocal) of invasive ductal carcinoma, Elston SBR grade 3. Extensive lympovascular space invasion is present. Skin, all margins negative for tumor. Metastatic disease present in 8/10 axillary lymph nodes. Dermal lymphatics of nipple positive for tumor. B. Left breast, simple mastectomy.  Breast with large prior biopsy cavity and lobular carcinoma in situ. Fibrocystic changes present.. No invasive carcinoma or ductal carcinoma present. M.d. (Electronic Signature) End Of Report.
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diff --git a/output/text/99f33172-22ac-4954-a73c-0fcecafc1628.txt b/output/text/99f33172-22ac-4954-a73c-0fcecafc1628.txt
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+History: rith metastatic sigmoid carcinoma here fox sigmoid resection and IHAp placement.. Specimens Submitted: 1: sp: Sigmoid colon, resection 2: SP: Gallbladder, excision 3: SP: Lymph node of callot, excision 4 Hepatic artery lymph node, excision. 5 SP:  Left fallopian tube and ovaxy, excision. 6: SP:  Right fallopian tube and ovary, excision. 7:  SP Proximal ring, excision 8: sP: Distal ring, excision DIAGNOSIS: 1. SP: Sigmoid colon, xesection: Tunor Type: Adenocarcinoma Histologic Grade: Moderately diffexentiated Tunor I Location: Sigmoid colon Tunor Size: Length is 5 cm Width is 4.5 cm Maximal thickness is 2.0 cm Tumo Budding: Extensive Inereased Tumor Infiltrating Lymphocytes:. Absent Precursor Lesions: Tubular adenoma Deepest Tumor Invaaion: Sexosal surface Gross Tumor Perforation: Not identified Lymphovascular Invasion: Suspected Large Venous Invasion: IdentiEied * Continued on next page
+
+--- Page 2 ---
+Page 2 of 6 Perineural Invasion: Identified Surgical Marging: Free of tumor yolyps/Mucosa Dysplasia (away from the carcinoma) : Not Identified Non-Neoplastic Bowel: Unremarkable Lymph Nodes: Number with metastaeis: 1 Total number examined: 17 Tumor deposits in pericolorectal soft tissue:. Identified Staging (AJcc 7th Edition): pT4a (Tumor penetrates to the surface of thevisceral peritoneum). Lymph Node Stage (AJCc 7th Edition):. N1 (Metastasis in 1-3 regional lymph nodes) Sp: Gallbladder, cholecystectomy: Gall bladder with chronic inflanmation and choleltthiaais. 3. Sr: Lymph node of callot, excision: -One benign lymph node (0/1). 4. Sp: Hepatic artexy lymph node, excision: -One benign lymph node (0/1). 5. SP: Left fallopian tube and ovary, excislon: -Benign fallopian tube and ovary.. 6. Sp: Right fallopian tube and ovary, excision: Benign ovary and fallopian tube with paratubal cyst.. 1. Sp: Colon, proximal ring, excision: -Benign colonic tissue. 8. Sp: Colon, distal xing, excision:. -Benign colonic tissue. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Grosa Description: 1).The apecimen is received fresh and is labeled "sigmoid colon". It. consists of a sigmoid colon that measures 9 cm in length and 2.5 cm in. ** Continued on next page **. $
+
+--- Page 3 ---
+Page 3 of 6. average diameter. The serosal surface is tan-pink smooth and gliatening with two focal puckered regions both 0.3 CM in greatest dimension. The radial resection margin is inked blue and the apecimen is opened to reveal a tumor that is located 10 cm from the proximal margin and five cm from the distal margin. The tunor measures five cm in length and 4.5 cm in width. Serial sectioning reveals an ulcerating tumor invading through the bowel wall into the pericolonic fat and extending to the puckered serosa, to a depth of 2 Cm, which is 4 cm from the closest xadial margin. The remaining mucosa shows normal folds and no gross abnormality..  Pericolic and peri-colonic adipose. tissue is submitted for lymph node dissection, and all possible aodes axe submitted. Representative sections are submitted. tps is subnitted.. Summary of sections:  PM - proximal margin DM - distal margin RM - radial margin PIN-grossly positive lymph nodes aubjacent tc . uninvolved mucosa LN - lymph nodes 2}. The apecimen is received fresh, labeled "Gallbladder" and consists of a. green and purple gallbladder measuring 8.2 x 4.2 x 2.5cm. The surface of the gallbladder is green purple and smooth.. It is opened to reveal. two black green angulated granular calculi measuring 1.4 cm and 1.5 cm in greatest dimenaion, with green black viscid bile.. It alao reveals a green yellow. velvety mucosa with a wall measuring up to 0.2 cm..  Representative sections including the cystic duct margin are submitted.. Summary of sections: M - cystic duct margin undesignated 3). The apecimen is received in formalin, labeled "Lymph node of callot" and consists of a single lymph node measuring 2.3 x 1.4 x 0.8 cm. The lymph node. is bisected and entirely submitted. Summary of sections: LN - lymph node 4). The apecimen is received in foxmalin , labeled "Hepatic artery lymph node" and consists of a single lymph node measuring 3.8 x 1.8 x 1.0 cm. The. lymph node is sectioned and entirely submitted.. ** Continued on next page **
+
+--- Page 4 ---
+Pag Summary of sections:. LN - lymph node 5).The specimen is received in formalin, labeled "Left fallopian tube and. ovary" and consists of a fallopian tube with attached ovary.  The fallopian tube measures 2.5  cm in length and averages 0.8 cm in dianeter. The external suxface of the tube is pink tan and smooth with a normal fimbriated end. Cut section through the tube reveals a pinpoint lumen.. The attached Ovary measurea 2.5 x 1.7 x 1.0 cm.  The external surface is white-tan and cerebriform. Cut section through the ovary reveals a white-tan appearance. Representative sections are submitted. Summaxy of sections: F . fallopian tube. ovary 6).The specimen is received in formalin, labeled "Right fallopian tube and. ovary" and consists of a fallopian tube with attached ovary. The fallopian tube measures 2.5 cm in length and averages 0.6 cm in diameter. The external surface of the tube is pink tan and amooth with a normal fimbriated end. There are several paratubal cysts identified which measure up to 0.A x 0.3 cm in greatest dimensions, Cut section through the tube xeveals a pinpoint Iumen. The attached ovary measurea 2.5 x 2 x 1.0 cm. The external surface is white-tan and smooth. Cut section through the ovary. reveals a white-tan appearance. Representative sectlons are submitted. Swnmary of sections: F - Eallopian tube 0 - ovary 7). The specimen is xeceived in formalin wrapped around an anastomotic pin,. Iabeled "proximal ring" and consists of a ring of pink tan soft tissue measuring 1.9 x 1.8 x 1.0 cm. Multiple sutures and staples are attached. The mucosal surface is pink tan and focally hemorrhagic. The suturea and staples are removed and the soft tissue is entirely submitted. Summary of sections: U - undesignated 8). The specimen is received in formalin, labeled "Distal ring" and consiats of a ring of pink tan soft tiasue measuring 2.5 x 2.5 x 1.5 cm. Multiple sutures and staples are attached. The mucosal surface is pink tan and focally hemorrhagic. The sutures and staples are removed and the soft tisaue is entixely submitted. Summary of sections: U - undesignated ** Continued on next page **
+
+--- Page 5 ---
+Page 5 of 6 Summary of Sectione: Part 1: Block Sect. site PCs r4 m DM 1 LN 16 m 11 PLN 3 PM 1 1 RM 5 r4 in H Part 2: Sp: Gallbladder, excisioir Block Sect. site PC 1 H 11 Part 3: sp: Lymph node of callot, excis Block Sect. Site PCg 1 Part 4: SP: Hepatic axtery lymph node, excision Block Sect. Site $Cg 2 In 2 Part 5: Sp: Left fallopian tube and ovary, excision Block Sect. Site PCs H H H r Part 6: SP: Right fallopian tube and ovary, Block Sect. site PCs 11 1 1 Part 7: SP: Proximal ring, excision Block Sect. Site PC 1 u 1 Part 8: SP: Distal ring, excision. Block Sect. Site PCs 1 u 1 ** Continued on next page **.
+
+--- Page 6 ---
+Page 6 of 6 End of Report
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index 0000000000000000000000000000000000000000..5b3322871feaff815c21008a170544cded29ef95
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+UUID:7726F7AA-88A8-4DD6-B322-6FC68893E0D2 Redacted *ADDENDUM* Addendum #1 Entered: BREAST CANCER PROGNOSTIC MARKERS Specimen: Paraffin block 4E Procedures: Paraffin Section Immunohistochemistry and DNA Flow Cytometry ASSAYS: RESULTS: FAVORABLE RANGES: Estrogen Receptors. POSITIVE, 3+ Positive (1 - 3+) Progesterone Receptors POSITIVE, TRACE TO 1+ Positive (1 - 3+) p1oidy/DNA Index (DI) AneUPLOID, DI=1.6 Diploid, DI = 1.0 S-Phase Fraction (%) NOT REPORTED Low (3% or less) DUE TO EXCESSIVE BACKGROUND Ki-67 (Proliferation marker) INTERMEDIATE, 16% Low (15% or 1ess) HER-2/neu (c-erb b2) NEGATIVE (0) Negative (0 - 1+) p53 NEGATIVE, 0 Negative These immunoperoxidase tests were developed and their performance characteristics determined by xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx. A1though not c1eared or approved by the u.s.Food and Drug Administration, the FDA has determined that such clearance or approval is not necessary.  These tests are used for clinical purposes and should not be regarded as investigational or for research. This laboratory is certified under the clinical Laboratory Improvement Amendments of 1988 (cLIA) as qualified to perform high complexity clinical laboratory testing. ID03 Addendum signed signature on file 852073 ( 50.9 Page 1 y s s/30/14
+
+--- Page 2 ---
+GROSS DESCRIPTION 1. Labeled "blue node left axilla #1": The specimen consists of multiple possible 1ymph nodes ranging from 0.1 to 1.3 cm in greatest dimension. The 1ymph nodes are submitted entirely as follows: 1A - one possible lymph node bisected, 1B - remaining possib1e' 1ymph nodes. Keratin ordered on both blocks.. 2. Labeled "second blue node left axil1a #2": The specimen consists of multiple possible 1ymph nodes ranging from 0.2 to 1.2 cm in greatest dimension.. .The lymph nodes are submitted entirely as follows: 2A - one possible lymph node bisected,' 2B - remaining possible lymph nodes. Keratin ordered on both blocks. Labeled "suspicious node left axilla": The specimen consists of a 2.0 x 1.3 x 0.2 cm pink firm possible lymph node. The lymph node is bisected and submitted entirely in 3A. 4. Labeled "segment left breast, long stitch - anterolateral, short stitch - anteromedial": ~The specimen consists of a 6.7 (media1 to lateral) x 4.3. (anterior to posterior) x 2.1 cm portion of tan yellow to gray white fibrofatty breast tissue. The specimen is inked as follows: superior - blue, inferior - green, posterior. black, anterior - red. Sectioning reveals a 4.0 x 2.8 x 2.0 cm gray white focally hemorrhagic i11 'defined mass which extends up to the superior,, posterior and inferior margins. The distance to the remaining margins is greater than 1.0 cm. The remaining cut surface  features a large amount of fibrocystic change. A portion of the mass and norma7 tissue is submitted to xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx for research (IRB# xxxxxxxxxxxxx) . Representative sections are submitted from lateral to medial in 4A-j with en face margins in'4A and 4J. The mass is in 4c-H.. Labeled "additional segment left breast": The specimen consists of a 6.1 x 3.9 x 3.2 cm portion of tan yellow to gray white fibrofatty breast tissue. One aspect of the tissue is hemorrhagic and ragged while the opposing surface is smooth. The specimen is inked as follows: ragged surface - blue, smooth surface - black. Sectioning reveals multip1e gray white gritty focally cystic suspicious areas which exude a yellow grummous material.The suspicious areas appear throughout the tissue and extend up to both margins. The majority of tissue to include closest margins are submitted in 5A-g. 6. Labeled "inferior margin left breast": The specimen consists of a 1.2 x 0.8 x 0.2 cm portion of tan yellow to gray white fibrofatty breast tissue. Submitted in toto in 6A. 7. Labeled "superior margin left breast": The specimen consists of a 1.2 x 0.6 x Page 2
+
+--- Page 3 ---
+0.2 cm portion of tan yellow to gray white fibrofatty breast tissue. Submitted in toto in 7A. 8. Labeled "medial margin, left breast": The specimen consists of a 1.2 x 0.8 x. 0.1 cm portion of tan yellow to gray white fibrofatty breast tissue. Submitted in toto in 8A. 9. Labeled "lateral margin, left breast": The specimen consists of a 1.3 x 0.5 x 0.3 cm  portion of tan yellow to gray white fibrofatty breast tissue. Submitted in toto in 9A. 10. Labeled "anterior margin, left breast": The specimen consists of a 1.1 x 0.5 x. 0.1 cm  portion of tan yellow to gray white fibrofatty breast tissue. Submitted in toto 10A. 11. Labeled "deep margin, left breast": The specimen consists of a 1.6 x 0.6 x 0.1 cm portion of tan yellow to gray white fibrofatty breast tissue. Submitted in toto in 11A. Microscopic H&e stained sections are prepared and interpreted. IMMUNOCYTOCHEMISTRY RESULTS Block 1A, at 2 levels: Keratin: Positive. Block 1B, at 2 levels:. Keratin: Positive in one node. Block 2A, at 2 levels: Keratin: Positive. Block 5B: E-cadherin: Negative in infiltrating carcinoma and in most of ducts involved by in situ carcinoma, consistent with lobular carcinoma.. DIAGNOSIS 1. SenTINEl LymPh nODeS, LEft AXIlLA: METASTATIC CARCINOMA IN TWO OF THREE LYMPH NODES (2/3). METASTATIC DEPOSIT MEASURES O.3 CM; NO EXTRACAPSULAR INVASION IDENTIFIED. IMMUNOHISTOCHEMICAL STAINS ARE CONFIRMATORY. 2. SENTINEL LYMPH NODES #2, LEFT AXILLA: METASTATIC CARCINOMA IN ONE OF ONE NODE (1/1). METASTATIC DEPOSIT MEASURES 1.O CM; NO EXTRACAPSULAR INVASION IDENTIFIED. IMMUNOHISTOCHEMICAL STAINS ARE CONFIRMATORY. 3. LymPh nODe, LEft AXIlLA, SUSpIcIouS: ONE NODE NEGATIVE FOR METASTATIC CARCINOMA (O/1). Page 3
+
+--- Page 4 ---
+BENIGN CAPSULAR AND TRABECULAR NEVUS. 4. Breast, Left, segmentectomy: INFILTRATING LOBULAR CARCINOMA, CLASSIC PATTERN. TUMOR MEASURES APPROXIMATELY 5 CM IN GREATEST DIMENSION AND EXTENDS TO SUPERIOR, LATERAL, INFERIOR AND POSTERIOR SPECIMEN EDGES. LYMPHOVASCULAR INVASION IDENTIFIED. PLEASE SEE BREAST CANCER PROGNOSTIC SUMMARY BELOW. 5. Breast, Left Additional Segment, Segmentectomy: INFILTRATING LOBULAR CARCINOMA INVOLVING MULTIPLE SPECIMEN EDGES (INCLUDING APPARENT OLD AND APPARENT NEW SPECIMEN EDGES). CARCINOMA EXTENDS THROUGH BULK OF THE TISSUE SEGMENT, MEASURING AppROXIMATeLy 5.0 CM IN GREATEST DIMENSION. IN SITU CARCINOMA WITH DUCTAL INVOLVEMENT CONSISTENT WITH ANTEGRADE SPREAD OF LOBULAR CARCINOMA IN SITU. LYMPHOVASCULAR INVASION IDENTIFIED. ADDITIONAL FINDINGS: PROLIFERATIVE BREAST DISEASE WITH MICROCALCIFICATIONS. 6. BREAST, LEFt, INFERIOR mARGIN, BIOPSY: INFILTRATING LOBULAR CARCINOMA MEASURING O.5 CM. SMALL FIBROADENOMA. 7. Breast, Left, Superior margin, biopsy: INFILTRATING LOBULAR CARCINOMA, MEASURING O.25 CM. 8. Breast, Left, medial mArgin, biopsy: BENIGN BREAST TISSUE. NEGATIVE FOR MALIGNANCY. 9. Breast, Left, Lateral margin, biopsy: INFILTRATING LOBULAR CARCINOMA, MEASURING APPROXIMATELY 1.2 CM. LOBULAR CARCINOMA IN SITU WITH EXTENSIVE DUCTAL INVOLVEMENT. 10. Breast, LEft, AnterIoR mArgIn, BIopSy: Benign breast tissue. : NEGATIVE FOR MALIGNANCY. 11. BREAST, LEFT, DEEP MARGIN, BIOPSY: BEnIgN FatTy BrEaSt TissuE. NEGATIVE FOR MALIGNANCY. BREAST CANCER PROGNOSTIC SUMMARY Site: LEFT BREAST TUMOR SIZE: 6.5 CM (ESTIMATED FROM SPECIMENS 4 AND 5) TUMOR TYPe: INFILTRATING LOBULAR CARCINOMA HISTOLOGIC GRADE: WELL DIFFERENTIATED MODIFIED BLOOM- RICHARDSON SCORE: 5/9 (DUCT FORMATION 3, NUCLEAR GRADE 1, MITOTIC ACTIVITY 1) IN SITU CARCINOMA: PRESENT TYPE: LOBULAR, WITH ANTEGRADE DUCTAL INVOLVEMENT EXTENSIVE IN SITU CARCINOMA : NOT IDENTIFIED MARGINS OF RESECTION: POSITIVE: CARCINOMA INVOLVES MULTIPLE MARGINS OF THE INITIAL SEGMENT, MULTIPLE MARGINS OF THE ADDITIONAL SEGMENT, Page 4
+
+--- Page 5 ---
+AND THE BIOPSIES OF INFERIOR MARGIN, SUPERIOR MARGIN AND LATERAL MARGIN. NIPPLE/SKIN InVOLVEMENT : nOT ApPLICABLE LYMPHOVASCULAR INVASION: PRESENT LympH nODes: POSITIVE # POSITIVE/TOTAL COUNT: 3 OUT OF 5 SENTINEl NOde: 3 OUT OF 4 SENTINEL NODES TNM PATHOLOGIC STAGE: pT3 N1a MX MOLECULAR STUDIES: PARAFFIN BLOCK 4E Signed Electronically signed by:. ** END OF REPORT ** Page 5
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+UUID: 8652E026-9C4D-4AB6-AADE-29DA3345892E TCGA-EW-A3U0-01A-PR Redacted Name: Case #: DOb: Age: Collected: Gender: F Received: MrN: Reported: Location: Copy To: Physician: Pathologic Interpretation: A. SPECIMEN LABELED SENTINEL NODE # 1 COUNT LEFT BREAST:  One lymph node, negative for carcinoma (0/1). B. SPECImeN LABELeD SEnTIneL nODe # 2 COunt LEfT BREAST: METASTATIC DUCTAL CARCINOMA in one lymph node (1/1), measuring 0.5 cm in linear dimension. C. SPECIMEN LABELED SENTINEL NODE #3 COUNT ) Left breast: One lymph node, negative for carcinoma (0/1). D. SPECimeN LABELED "NON-SEnTINEL Lymph nODE LEft BREAST": One lymph node, negative for carcinoma (0/1). E. LEFT BREAST EXCISION: INVASIVE DUCTAL CARCINOMA, moderately differentiated, Nottingham grade 2 (3+2+1=6), 8.5 cm in greatest dimension, asociated with calcifications Nerarest margins: Posterior, 1 mm (E2); medial, 3mm (E16); anterior, 5 mm (E4); lateral, inferior and superior, >5mm. Negative for lymphovascular invasion. DUCTAL CARCINOMA IN SITU, intermediate nuclear grade, solid and cribriform type, DiN II, associated with necrosis and calcifications, present is 8 out of 17 slides.  Nearest margins: inferior <1mm (E7); medial 1mm (E12); posterior 2mm (E2);anterior 5mm, superior and. Iateral >5mm. Extensive intraductal component negative.. 1Cd-O-3 Note: Immunohistochemistry stains on a prior specimen were: ER NEGATIVE (<1%) carcinoma, duct' PR NEGATIVE (<1%) HER2NEGATIVE (0) in 5+raH^q F. SPECImEN LABELED "ADDITIONAl ANTERIOR MARGIN, LEFt BREAST": 8 5003 Negative for carcinoma. Sit: breast,nos Skin with no specific pathologic changes.. C SO 9 4Q-12 RO
+
+--- Page 2 ---
+G. LEft Lymph node DiSSEction, AXIlLA: Two lymph nodes, negatve for carcinoma (0/2). H. LEFT LYMPH NODE DISSECTION, AXILLA: Nineteen lymph nodes, negative for carcinoma (0/19). Pathology Cancer Case Summary: INVASIVE CARCINOMA OF THE LEFT BREAST: Specimen Type: Partial breast Procedure: Excision with wire-guided localization Lymph Node Sampling: Sentinel lymph node(s) Axillary dissection (partial or complete dissection) Other lymph nodes (eg. location not identified) Specimen Integrity: Multiple designated specimens (eg, main excision and identified margins) Specimen Size: Greatest dimension: 9.0 cm Additional dimensions: 6.5 x 3.8 cm Specimen Laterality: Left Tumor Size: Size of Largest Invasive Carcinoma: Greatest dimension of largest focus of invasion over 0.1 cm: 8.5 cm Additional dimensions: 6.0 x 3.3 cm Tumor Focality: Single focus of invasive carcinoma Macroscopic and Microscopic Extent of Tumor: Skin: Skin is not present Nipple: DCIS does not involve the nipple epidermis Skeletal Muscle: No skeletal muscle present Ductal Carcinoma in Situ: DCIS is present Extensive intraductal component (EiC) negative Size (Extent) of DCIS: Number of blocks with DCIS: 8 Number of blocks examined: 17 Architectural Patterns: Cribriform Solid Nuclear Grade: Grade II (intermediate) Necrosis: Present, central (expansive "comedo" necrosis) Lobular Carcinoma in Situ: Not identified  Histologic Type of Invasive Carcinoma: Invasive ductal carcinoma (no special type or not otherwise specified) Histologic Grade: Glandular (Acinar)/Tubular Differentiation: Score 3 Nuclear Pleomorphism: Score 2 Mitotic Count: Score 1 Overall Grade: Grade 2 Margins:  Uninvolved by invasive carcinoma Distance from closest margin: 1 mm, posterior, medial Specify margins: Distance from superior margin: >5 mm Distance from inferior margin: > 5mm (E7) Distance from anterior margin: 5 mm (E4) Distance from posterior margin: 1 mm (E2) Distance from medial margin: 3 mm (E16) Distance from lateral margin: >5 mm Uninvolved by DCIS
+
+--- Page 3 ---
+Distance from closest margin: <1 mm, inferior Specify margins:. Distance from superior margin: >5 mm Distance from inferior margin: <1mm (E7) Distance from anterior margin: 5 mm (E4) Distance from posterior margin: 2 mm (E2) Distance from medial margin: 1 mm (E12)  Distance from lateral margin: >5 mm Treatment Effect: Response to Presurgica! Therapy: In the breast: No known presurgical therapy Lymph-Vascular Invasion: Not identified Dermal Lymph-Vascular Invasion: Not identified. Lymph Nodes: Number of sentinel lymph nodes examined: 3 Total number of lymph nodes examined (sentinel and nonsentinel): 25 Number of lymph nodes with macrometastases: 1 Number of lymph nodes with micrometastases: 0 Number of lymph nodes with isolated tumor cells: 0 Size of largest metastatic deposit: 5.0 mm Extranodal Extension: Not identified Method of Evaluation of Sentinel Lymph Nodes:. Hematoxylin and eosin (H&E), one level Primary Tumor: pT3: Tumor >50 mm in greatest dimension Regional Lymph Nodes:  pN1a: Metastases in 1 to 3 axillary lymph nodes, at least 1 metastasis greater than 2.0 mm Distant Metastasis: Not applicable Ancillary Studies: Estrogen Receptor: Performed on another specimen Specify specimen: Results: NEGATIVe, Less than 1% immunoreactive cells present Progesterone Receptor: Performed on anather specimen Specify specimen Results: NEGATIVE, Less than 1% immunoreactive cells present Her2: Performed on another specimen Specify specimen: Results: NEGATIve, Score 0 Microcalcifications: Present in DCIS Present in invasive carcinoma NOTE: Some immunohistochemical antibodies are analyte specific reagents (ASRs) validated by our laboratory. These ASRs are clinically useful indicators that do not require FDA approval The results are read by a pathologist as positive or negative. As the attending pathologist, I attest that I: (i) Exumined the relevant preparation(s) for the specimen(s): and (ii) Rendered the diugnosis(es). Intraoperative Consultation A. Sentinel node # 1 Count Left breast: Negative for carcinoma (0/1) B. Sentinel node # 2 count left breast: One lymph node, positive for carcinoma (1/1) C. Sentinel node # 3 count ' left breast: Negative for carcinoma (0/1)
+
+--- Page 4 ---
+Clinical History: Breast cancer Operation Performed Left partial mastectomy and left sentinel lymph node biopsy. Specimen(s) Received: A: SENTINEL NODE # 1 COUNT : LEFT BREAST B: SENTINEL NODE # 2 COUNT i LEFT BREAST C: SENTINEL NODE #3 COUNT ) left BreaSt D: NON-SENTINEL LYMPH NODE LEFT BREAST E: LEFT BREAST MASS-ONE STITCH SHORT SUPERIOR, LONG IS LATERAL F: ADDITIONAL ANTERIOR MARGIN G: LEFT AXILLA H: LEFT AXILLARY CONTENTS Gross Description: A. Received fresh labeled "Sentinel node # 1 Count  - left breastr. The specimen consists of a lymph node with surrounding fibroadipose tissue which measures 1.5 x 1.5 x 0.2 cm. The specimen is submitted in toto in cassette. B. Received fresh labeled *Sentinel node # 2 count left breast". The specimen consists of a lymph node. with  surrouding fibroadipose tissue which measures 1.5 x 1.0 x 0.2 cm. The specimen is submitted in toto in cassette! C. Received fresh labeled "Sentinel node # 3 count.  . left breast". The specimen consists of a lymph node. with surrounding fibroadipose tissue which measures 1.5 x 1.2 x 0.2 cm. The specimen is submitted in toto in cassette  D. Received in formalin labeled "Non-sentinel lymph node - left breast". The specimen consists of a lymph node with surrounding fibroadipose tissue which measures 1.0 x 1.0 x 0.5 cm. The specimen is bisected and submitted in toto in. one cassette. E. Received fresh labeled "Left breast mass -- one stitch short superior -- long lateral". The specimen consists. of a left lumpectomy specimen which measures 9.0 cm from medial to lateral by 6.5 cm from inferior to superior by 3.8 cm from anterior to posterior. There are two sutures; the long designating lateral and the short is designating superior. There is a firm, white, irregularly shaped and poorly defined mass located in the center of the specimen with diffuse extension to the medial and lateral margin. The extensions are.  surrounding by white indurated areas. The tumor appears to be less than 1mm from the superior margin less than 1mm from the posterior margin. The tumor with indurated area appears to be less than 1mm from. the inferior margin. The tumor appears to be less than 1mm from the anterior margin, less than 1mm from the medial margin'and less than 1mm from the lateral margin. The main part of the tumor measures 3.5 x 3.5 x 3.0 cm. But with the extensions and indurated areas the tumor measures 9.0 x 6.5 x 3.8 cm. The specimen isinked as follows:. Posterior black Anterior yellow Superior blue Inferior green  Lateral orange Medial red A section of tumor was taken fresh from frozen section for research. Approximately 50% of the section is submitted. Sections are submitted as follows: Cassettes #1&2 Tumor in relation to deep posterior margin
+
+--- Page 5 ---
+Cassettes #3&4  Representative sections of tumor in relation to anterior margin. Cassettes #5&6  Representative section of tumor in relation to superior margin Cassettes #7&8 Relationship of tumor to inferior margin Cassettes #9&10 Relationship of tumor to the lateral margin Cassettes #11&12 Representative section of tumor to the medial margin Cassette #13 Additional section of tumor near the posterior margin Cassette #14 Additional section of tumor near anterior margin Cassette #15 Representative section of possible biopsy cavity Cassette #16 Representative section of tumor with central focal hemorrhage. Cassette #17 Possible biopsy site F.  Received in formalin labeled "Additional anterior margin". The specimen consists of a fragment of skin with attached  fibroadipose tissue, skin measures 12.0 x 1.1 cm and is tan-brown in color. Adipose tissue. measures 1.5 x 0.8 cm. No lesions are identified. The specimen is sectioned and skin is submitted toto in. five cassettes. G. Received in formalin labeled "Left axilla". The specimen consists of a fragment of fibroadipose tissue which measures 2.0 x 1.5 x 0.9 cm. The largest lymph node measures 1.0 x 0.5 x 0.5 cm and is inked green. There  is one additional lymph node identified. The specimen is submittedin toto in cassette one. The largest lymph node is bisected. H.  Received in formalin labeled "Left axillary contents". The specimen consists of a fibroadipose tissue which measures 11.0 x 8.0 x 4.0 cm. The specimen is unoriented. No skeletal muscle is identified. The largest Iymph node measures 2.6 x 1.5 x 0.7 cm. The sections are submitted as follows:. Cassette #1 Three lymph nodes. Cassette #2 One lymph node Cassette #3 One lymph node. Cassette #4 One lymph node. Cassette #5 One possible lymph node Cassette #6 Two lymph nodes. Cassette #7  Four possible lymph nodes Cassette #8 Three possible lymph nodes Cassette #9  Three possible lymph nodes Cassette #10 Four possible lymph nodes
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diff --git a/output/text/9a3659d2-f086-49fb-abb3-4ab314af4a34.txt b/output/text/9a3659d2-f086-49fb-abb3-4ab314af4a34.txt
new file mode 100644
index 0000000000000000000000000000000000000000..08a364210636a1a0b2d78c747b241112e4a6cbf3
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+--- Page 1 ---
+UUID:F93869FD-9F81-4BB1-B0A4-489E5293C31 TSS Patient ID: Surgical Date: Gross Description: In bladder, it is invasive and protruded masse, ill - margins with 5x4x4cm in size,. soft and gray surface. Microscopic Description: Tumor cells are hyperplastic to form nest or groups or cords or tubules. Tumor cells have moderate and eosinophilic or clear cytoplasm. Nuclei are very enlarged and varriability in. shape and size, irregular nuclear membranes, nucleoli and abnormal chromatin patterns. Mitoses are present. Tumor invades in muscle propria or nerves. Diagnosis Details: Infiltrating urothelial carcinoma, high-grade, infiltrating muscularis propria. Comments: Formatted Path Reports: BLADDER TISSUE CHECKLIST Specimen type: Cystectomy Tumor site: Bladder (Pu T3S, sife 1s bhsdw wnll.) Tumor size: 5 x 4 x 4 cm CLeE ID0-3 Tumor features: None specified C@rsensno,ursteleaI NoS Histologic type: Transitional cell carcinoma 812d13 H Histologic grade: Poorly differentiated Carcenna tranwlionosall NOS 8/20/3 Tumor extent: Muscularis propria Out %addu woQQ N03 CJo77 Lymph nodes: Not specified 1714 Lymphatic invasion: Not specified Venous invasion: Not specified. Margins: Not specified Evidence of neo-adjuvant treatment: No Additional pathologic findings: Extracapsular extension: present, focal Comments: None Tvuor site dutuied by TSS + bc b1sddn wulL.su dx discrpercy borm Jill
+
+--- Page 2 ---
+TCGA Pathologic Diagnosis Discrepancy Form V4.00 Instructions: The TCGA Pathologic Diagnosis Discrepancy Form should be completed when the pathologic diagnosis. documented on the initial pathology report for a case submitted for TCGA is inconsistent with the diagnosis provided on the Case Quality Control Form completed for the submitted case. Tissue Source Site (TSS): TSS Identifier: -.!  Tss Unique Patient Identifier: - Completed By (Intervlewer Name o. Completed Date: Dlagnosis Information # Data Element Entry Alternatives Working Instructions Provide the diagnosis/histologic subtype(s) documented on  Pathologic Diagnosis Trausrtione cell the initial pathology report for this case. If the histology for Provided on Initial this case Is mixed, provide all Histed subtypes.. Pathology Report eerei nema Histologic features of  Provide the histologic features selected on the TCGA Case Mwscke imasivi Quality Control Form completed for thls case.. the sample provided 2  for TCGA, as reflected on the CQCF. Dlscrepancy between Pathology Report and Case Quallty Control Form  Provide the reason for  Provide a reason describing why the dlagnosls on the initial Speific. locodieu of- the discrepancy pathology report for this case is not consistent with the diagnosis selected on the TCGA Case Quality Control Form.  between the pathology tvmer within Hhe bWadqLer report and the TCGA Case Quality Control was not qiven rn paH Form. veport, but was qive. on CQ cF witfi+u tvme$r hing located onH wal of H paddler.  Name of TSS Reviewing  Provide the name of the pathologist who reviewed thls case for TCGA. Pathologist or Biorepository Director I acknowledge that the above informatlon n  my instltutlon is true and correct and has been quality controlled. TSS Reviewing Pathologist or Biorepository Director Date I acknowledge that the above information provided by my Institutlon Is true and correct and has been quality controlled. The Attending Pathologist or the Department Chairman has been informed or Is aware of the above discrepancy in diagnoses. Principal Investigator Signature Date
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diff --git a/output/text/9a3979b6-7a0e-416e-a745-564d04c6e14d.txt b/output/text/9a3979b6-7a0e-416e-a745-564d04c6e14d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9fa44f7f0bc848ffbf6b47f9acb88798fb4c4e6c
--- /dev/null
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+
+--- Page 1 ---
+Surgical Pathology Report Name: Dob: Case #: Collected: Gender: Received: MrN: Reported: Location: Copy To: Physician: Pathologic Interpretation: A. Sentinel node #1: - No carcinoma seen in one lymph node (0/1) - Keratin Immunostain is negative. 1cs-0-3 B. Suspicious node: carnomu, sasl cll sOs 809p/3 - No carcinoma seen in one lymph node (0/1) Sit: buast, Nos C 50.9 - Keratin Immunostain is negative. 3/1/n h c. Sentinel node #3: - No carcinoma seen in one lymph node (0/1) - Keratin Immunostain is negative. D. Left breast lumpectomy: - Invasive, poorly differentiated mammary carcinoma, high nuclear grade, 2.5 cm.. - Margins are free of tumor. - Tumor cell have been reported to be ER, and PR negative by Immunohistochemistry and HER2 negative by CISH. - In house immunostains are pending for further tumor subclassification.. Su idcundu- Corrm.. Tumor Summary: Caunone r baov! .ull srht.... Specimen Type: Partial breast. Procedure: Excision without wire-guided localization Lymph Node Sampling: Sentinel lymph node Specimen integrity: Left Speclmen Size: - Greatest dimension: 5 cm - Additional dimensions: 4 x 3.5 cm. Laterality: Leftd Tumor Site: Not specified Size of Invasive Component:d - Greatest dimension of largest focus of invasion: 2.5 cm.. - Additional dimensions: 1.8 x 1.8 cm. Tumor Focality: Single focus of invasive carcinoma Macroscopic and Microscoplc Extent of Tumor: Skin: Skin is not present. Skeletal Muscle: No skeletal muscle present Ductal Carcinoma in Situ (DCIS): No DCIS is present. Lobular Carcinoma in situ (LCiS): Not identified. Histologic Type: invasion carcinoma. In house immunostains are pending for further tumor subclassification. Histologic Grade: Overall Grade: Grade 3+3+2=8  - Gtandular (Acinar)/Tubular Differentiation: Score 3 <10% of tumor area forming glandular/tubular structures - Nuclear Pleomorphism: Score 3: Vesicular nuciei, often often with prominent nucleoli, exhibiting marked variation in size and shape, occasionaily with very large and bizarre forms. - Mitotic Count: Score 2 Margins: Margins uninvolved by invasive carcinoma. UUID: 2153CBCE-6DA9-4E0F-9F41-B9F08FD50647 - Distance from closest margin: 2 mm (Posterior).. TCGA-EW-A1OW-01A-PR Lymph-Vascular Invasion: Not identified. Redacted Dermal Lymph-Vascutar invasion: No Skin present. Lymph Nodes: Number of sentinel nodes examined: 3 Total number of nodes examined (sentinel and Nonsentinel): 3 Number of lymph nodes with macrometastases (>0.2 cm): 0 Number of iymph nodes with micrometastases (>0.2 mm to 0.2 cm and/or >200 cells): 0 Number of lymph nodes with isolated tumor cells (<0.2 mm and s200 cells): 0.
+
+--- Page 2 ---
+SURGICAL PATHOL Report Size of largest metastatic deposit: 0 Method of Evaluation of Sentinel Lymph Nodes:. - Hematoxylin and eosin (H&E). one leve). - Immunohistochemistry. Pathologic Staging: - Primary tumor: pT2 - Regional Lymph nodes: pN0 (sn) (i-). - Distant Metastasis: pMX Additional Pathologic Findings: - Other ancillary Studies: Performed on another specimen, '. ER: Immunohistochemistry = Negative. PR: Immunohistochemistry = Negative.. HER2: Immunohistochemistry = Negative. HER2 CISH -- Not amplified. Pathologic Staging (pTNM): pT2, N0 (i-) (sn), MX NOTE: Saune immwxshistochemical aruihotes are analyr speciflc reogens (ASRs) vairkned try our lahoraiory. Thew ASRs are clnicall neful indicanrrs thal do mu regmire Fl)A approval. Tiex clons are used: As the attending pathologist, I attesi that I: (i) Examined the relevont preparation(s) for the specimen(s): and (ii) Rendered the diagnosis(es). +**Electronically Signed Out By*** Procedures/Addenda Status: Signed Out Date Ordered: Addendum Date Complete: Date Reported: Addendum Diagnosis Left breast lumpectomy0: - The tumor cells are focally positive for p63 and EGFR by Immunohistochemistry., The morphology and immunophenptype of this  neoplasm is consistent with a carcinoma of basal cell subtype. , MD,PhD Intraoperative Consultation A. Sentinel node #1 FS: No carcinoma seen B. Suspicious node FS: No carcinoma seen J, m Clinical History:  None provided Page 2 of 3
+
+--- Page 3 ---
+SURGICAL PATHOL Report Operation Performed Left breast lumpectomy: left breast lumpectomy with sentinel node biopsy, axillary node dissection Pre Qperative Diagnosis: Breast cancer Specimen(s) Received: A: Sentinel node #1 FS B: Suspicious node FS C: Sentinel node #3, internal mammary (permanent) D: Left breast lumpectomy Gross Description:. A.  Received fresh there is a 1 x 0.8 x 0.3 cm lymph node. Bisected and submitted in toto for frozen section in tvo cassettes. B. Received fresh there is a 2 x 1 x 0.3 cm lymph node. Bisected and submitted in toto in two cassettes for froten section. C. Received in formalin there is a 0.3 x 0.2 x 0.2 cm lymph node. Submitted in toto. D. Received in formalin there is a lumpectomy specimen of 5 x 4 x 3.5 cm and 40 grams. Specimen is oriented with short stitch in the superior margin and a long stitch in the lateral margin. Specimen is inked as follows: blue superor, green inferior. yellow anterior, black posterior, red medial, and orange lateral. There is a palpable indurated pale tan mass of 2.5 x 1.8 x 1.8 cm. Closest resection margin is the posterior margin at 0.2 cm. Superior margin are 0.7, infelior margin at 1 cm, lateral margin at 2.5 cm, and medial margin at 1.5 cm. There are no additional lesions in the remainder of the parenchyma. Fat to stroma ratio is 40:60. Representative sections are submitted as follow: 1  Superior posterior resection margin 2 Inferior posterior margin 3 Medial margin 4 Lateral margin 5 Inferior margin 6-9 Remaining stroma 10 Additional section of tumor MC , MD Page 3 of 3
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diff --git a/output/text/9a63e64d-6c46-45aa-9ec8-46298efaef2b.txt b/output/text/9a63e64d-6c46-45aa-9ec8-46298efaef2b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..29328aa1b2e8355a65cc32c284d9506a93b6f7b2
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+
+--- Page 1 ---
+PAGE 1 RUN DATE: RUN TIME: User: RUN USER: ACCT #: PATIENT ROOM: REG AGE/SX : DIS: DOB: BED: REG DR: STATUS: RECD: STATUS: SPEC # TIME IN FORMALIN: 6:26 hrs. COLL: COLD ISCHEMA TIME: 0:00 mins. CLINICAL INFORMATION:S Colon cancer Pre-Op Diagnosis: Remarks: ted-o-3 Spacimen(s): A. Omental implant B. Left colon 84$s/3 C. METs Site: Keesendirey eelm ) 6 I3I3 OMENTAL IMPLANT) RESECTION: METASTATIC MUCINOUS ADENOCARCINOMA CONSISTENT WITH COLON PRIMARY B. LEFT COLON, LEFT HEMICOLECTOMY:S MUCINOUS ADENOCARCINOMA OF THE DESCENDING COLON POSSIBLY ARISING IN TUBULOVILLOUS ADENOMA CARCINOMA INVADES THROUGH COLON WALL INTO SUBSEROSAL ADIPOSE TISSUE AND EXTENDS TO WITHIN 1 MM OF PERITONEAL SURFACE AND RADIAL MARGIN TUMOR ADHERENT TO ABDOMINAL WALL BY CLINICAL HISTORY SURGICAL MARGINS OF RESECTION FREE OF TUMOR WITH CLOSEST MARGIN RADIAL MARGIN 1 MM METASTATIC MUCINOUS ADENOCARCINOMA, IN THREE (3) OF NINETEEN (19) SUBSEROSAL LYMPH NODES LYMPH-VASCULAR INVASION NOT IDENTIFIED SEE COMMENT FOR SURGICAL PATHOLOGY CANCER CASE SUMMARY CHECKLIST C. PERITONEAL METASTASES. RESECTION:S  MUCINOUS ADENOCARCINOMA CONSISTENT WITH METASTATIC COLON CARCINOMA COMMENT(S) the specimen will be forwarded for KRas analysis. Results will At request of be reported as an addendum when complete. SURGICAL PATHOLOGY CANCER CASE SUMMARY - APPROVED BY COLLEGE OF AMERICAN PATHOLOGISTS Descending colon UUID: B4D412AD-FD5C-4397-B56E-62F39A3757510 SPECIMEN: TCGA-NH-A6GC-01A-PR Redacted Left hemicolectomy PROCEDURE: Left (descending) colon. TUMOR SITE: ** CONTINUED ON NEXT PAGE *
+
+--- Page 2 ---
+RUN DATE: RUN TIMI PAGE 2 RUN USER: User: SPEC #: PATIENT: (Continued) cOmmenT(S) (Continued) TUMOR SIZE: 8.0 cm MACROSCOPIC TUMOR PERFORATION: Not identified HISTOLOGIC TYPE: Mucinous adenocarcinoma HISTOLOGIC GRADE: Low-grade MICROSCOPIC TUMOR EXTENSION: Tumor is adherent to other organs or structures. abdominal wall MARGINS : If all margins uninvolved by invasive carcinoma. distance of invasive carcinoma from closest margin: 1 mm, radial Proximal margin: uninvolved by invasive carcinoma Distal margin: uninvolved by invasive carcinoma Circumferential margin: uninvolved by invasive carcinoma TREATMENT EFFECT: No prior treatment LYMPH-VA:  .AR INVASION: Not identified PERINEUE....  INVASION: Not identified TUMOR : :FOSITS: Not identified TYPE OF FOLYP IN WHICH INVASIVE CARCINOMA AROSE: Tubulovillous adenoma - possible PATHOLOGIC STAGING: Primary tumor: pT4b Regional lymph nodes:. pN1b Number of lymph nodes examined: 19 Number of lymph nodes involved: Distant metastasis: ? pM1b. omentum and peritoneum ANCILLARY STUDIES: KRAs mutational analysis pending GROSS DESCRIPTION: The specimen is received in three parts. Each part is labeled with the patient's name. A. Labeled "omental implant" is received fresh for frozen section diagnosis and is a 9.0 x 6.0 x 2.5 cm diffusely indurated. nodular portion of yellow. lobulated omental adipose. The adipose has multiple. mucinous tumor masses with two large masses ranging up to 6.0 x 4.5 x 2.5 cm. The section is sampled for frozen section diagnosis. The tissue is sampled to have solid to minutely cystic. mucin-fillad masses throughout the specimen. A section is sampled for frozen section diagnosis. An additional section is sampled for tissue banking.. Additional representative sections are sampled from across the specimen: A1 frozen section residue A2-a4 additional sections sampled B. Labeled "left colon" and received fresh for tissue banking is a 23 cm segment of large bowel. The bowel has a distal area of indurated, creeping fat. This region is inked blue on the serosa. The bowel is opened to have an 8.0 x 7.0 x 3.0 cm mucinous tumor mass. The mass comes to within 4.5 cm of the distal margin. 14 cm from proximal. The tumor diffussly involves and extends through the bowel wall and extends close to the inked serosa and. mesenteric. radial fat margin. There is 1.5 cm of adipose between the bowel wall and radial fat margin. The tumor axtends nearly to this inked margin. Surrounding mucosa is otherwise unromarkable with normal. tan folds. The adipose is sectioned to have multiple nodular lymph nodes. The lymph nodes are focally tumor replaced with a mucinous appearing cut ** CONTINUED ON NEXT PAGE **
+
+--- Page 3 ---
+RUN DATE RUN TIME! PAGE 3 RUN USER: User SPEC # PATIENT: Continued) GROSS DESCRIPTION:(Continued) surface. Sections of the tumor are sampled for tissue banking. Representative sections are sampled for routine histology as labeled:. B1 proximal margin B2 distal margin B3-B7 sections of tumor extending through bowel wall into underlying adipose to the inked serosal and radial fat margin. B8-B11 whole lymph nodes from proximal to distal. B12 tumor replaced lymph node sampled. C. Labeled "MErs" and received in formalin is a 5.0 x 3.0 x 2.0 cm portion of yellow adipose. The adipose has two mucinous tumor nodules at aither pole. The smaller nodule is 1.0 cm and the larger nodule is 2.3 x 2.3 x 1.7 cm. Representativs sections are sampled to include normal. adjacent omental adipose cassettes C1-c2.. MICROSCOPIC DESCRIPTION : The slides are examined and evaluated. INTRAOPERATIVE CONSULTATION:S FROZEN SECTION DIAGNOSIS. OMENTAL IMPLANT:S METASTATIC ADENOCARCINOMAS ETATICH Image Image Image Image Image Signed (signature on file) ** END OF REPORT **
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diff --git a/output/text/9a9c06a3-fe1b-4bd7-b286-3aeec2b69167.txt b/output/text/9a9c06a3-fe1b-4bd7-b286-3aeec2b69167.txt
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index 0000000000000000000000000000000000000000..5697b93401d857e9e647f05afb4301cd6b94ddf7
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+--- Page 1 ---
+Date of surgery : O.h OCowid c49 3 Left eye enucleation 3/c/14 Macroscopy The eyeball measures 25 mm and the optic nerve 5 mm. Samples have been made for cryo preservation .The specimen has been then included entirely Microscopy The eyeball is occupied by a tumor proliferation which morphologic features are those of a fusiform cell melanoma.. The lesion is loaded with melanin pigment. The mitotic index is low with 1mitosis out of 10 high 400 magnification fields. The lesion infiltrates the internal third of the sclera. There is no extra scleral extension. The tumor proliferation is distant from the internal emergence of the optic nerve. The optic foramen, the pre and post laminar section, the cut end and the meningeal sheaths are free of tumor. The iris, the ciliary body and the anterior chamber are free of tumor. Conclusion Choroidal melanoma with fusiform cells Size of the lesion: 15 mm Low mitotic activity Optic nerve (optic foramen, per and post laminar sections), meningeal sheaths and cut end of optic nerve free of tumor The iris, the ciliary body and the anterior chamber are free of tumor. UUID:C8E6E160-2B5D-466D-8C44-42516303F5A9 TCGA-V4-A9E9-01A-PR Redacted 30 1702013
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diff --git a/output/text/9abbc853-40e7-4d51-8730-ae032861dd51.txt b/output/text/9abbc853-40e7-4d51-8730-ae032861dd51.txt
new file mode 100644
index 0000000000000000000000000000000000000000..32b83bbd77628fef288f6467d3bd975c675f1479
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+
+--- Page 1 ---
+MEDICAL RECORD Surgical Pathology Report. Surgical Pathology Report. PATIENT: MRN: ACCOUNT#: RECEIVED DATE: DOb: PrOcEDURE DATE: AGE: SEX: SIGN-OUT DATE: ATTENDING: LOCATION: REQUESTING: ROOM: CONTACT NO: (MD COPIES TO: DlAGnosis: Kidney, right (total nephrectomy): Renal cell carcinoma, chromophobe cell type, Fuhrman nuclear grade II of IV, see Note. -Tumor does not involve surgical margins or ureteral and vascular margins.. -Nephrosclerosis and moderate atherosclerosis involving the renal artery.. NOTE: Kidney Nephrectomy Summary Table Macroscopic Specimen Type: Radical nephrectomy Laterality:> right Tumor Size: 2.1cm Focality: unifocal Macro Extent of Tumor: tumor limited to kidney Microscopic Histologic Type: chromophobee Histologic Grade: G2 Extent of Invasion Primary Tumor(pT): pT1a Regional Lymph Nodes(pN):pNX Distant Metastisis(pM): pMX Margins: uninvolved by carcinoma CLINICAL INFORMATION: Brief Clinical History: pt with right renal mass Specimen Taken For Protocol: Requestor Name  Requestor Phone/Pager: Admitting Protocol Number: PROcEDuRE: Pre-Operative Diagnosis: right renal mass Post-Operative Diagnosis: right renal mass Operative Patient Identification. File in Section 3: Tissue Examination Page 1
+
+--- Page 2 ---
+MEDICAL RECORD Surgical Pathology Report Name: Accession No.: MRN: Date of Report: Findings: right renal mass SPECIMENS SUBMITTED: KIDNEY, RIGHT, And Gerota's fascia GROss DEscRIPriON: The specimen is received is a single container labeled with.the patient's name,. medical record number, and "right kidney and Gerota's fascia". The specimen consists of a nephrectomy weighing 215.1 grams and measuring 12 x 10 x 4 cm in dimension. No palpable mass is present. The surgica margin is inked in black and bivalved via the antehilar surface to reveal a kidney-colored nodule measuring 2.1 x 1.5 cm at the corticomedullary junction. The tumor is greater than 2 cm from the closest surgical margin and is well circumscribed. A 1 x 1 cm piece of nodule and a 1 x 1 cm piece of normal-appearing parenchyma is procured for UOB. Photographs have been taken of the case. The procurement was performed by  In Surgical Pathology, the specimen is received in a formalin-filled container. The. specimen has been previously bivalved and half of the tumor has been shelled out. The remainder of the tumor is located at the corticomedullary junction. Cut sectioning of the tumor demonstrates a brownish, normal- appearing kidney parenchyma surrounding the nodular tan-brown tumor mass. Deep to the tumor within the cortex is a clear fluid-filled cortical cyst. On half of the kidney which was previously procured, the tumor appears to infiltrate into the normal-appearing kidney parenchyma with pushing borders in a very thin white capsule surrounding the tumor from the normal kidney. The tumor does not appear to involve the hilum and is 0.3 cm from the hilar edge of the kidney, and 0.4 cm from the perinephric fat. The vascular and ureteral margins are grossly free of tumor. Sectioning through the remainder of the kidney demonstrates brown-tan, unremarkable kidney parenchyma with no additional nodules are mass is seen. There is no perinephric fat surrounding the capsule of the kidney deep to the tumor nodule. Sectioning through the hilar fat demonstrates no lymph node candidates. Analysis of the renal artery demonstrates an area of atherosclerosis which is approximately 60% occluded. There are no additional nodules or masses seen in the perinephric fat.. Representative sections are submitted as follows:. I A-C - tumor at closest surgical margin and hilum. 1 D - vascular and ureteral margin E - normal kidney parenchyma :  F - atherosclerotic blood vessel cross-section Gross dictated by Patient Identification Surgical Pathology Report File in Section 3: Tissue Examination Page 2
+
+--- Page 3 ---
+MEDICAL RECORD Surgical Pathology Report Name: Accession No.:. MRN:E Date of Report: Patient Identification Surgical Pathology Report File in Section 3: Tissue Examination Page 3
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diff --git a/output/text/9ac45736-4643-47cf-b8d3-30d81c1267ba.txt b/output/text/9ac45736-4643-47cf-b8d3-30d81c1267ba.txt
new file mode 100644
index 0000000000000000000000000000000000000000..03441f153dd695f54b039b08963f412be5b4e0f0
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+
+--- Page 1 ---
+1c D-0 -3 Carcinomn, inpi1tnu#y ductl,N0s 85oof3 c5o.5 1/05/ Pith S.t: brast LOQ CQCF Sih: hrsst, Nog 50.9 Diagnosis 1. Left-sided ablated breast tissue with a poorly differentiated invasive ductal breast carcinoma measuring a good 55 mm with invasion of the lymph vessels and focally also of the blood vessels, infiltration of the overlying epidermis with very slight paracentral erosion and extension to the basal resection margin with infiltration of the resection margin. The nipple is tumor-free, including the lactiferous sinus and the other glandular tissue with a fibrocystic mammopathy. Assessment: According to these findings, complete removal of the carcinoma as far as the basal epidermis is not definite. Tumor classification: M-8500/3, G 3, pT4b, pL1, pV1, pN1a (1/11), pMx, stage II B. R1. UUID: C5586F4B-1248-4FBF-83C2-B0A18330EA03  Redacted CGA-A8-A09E-01A-PR
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diff --git a/output/text/9adbbcb5-e4dd-4ef0-bf97-27fd0ac4b527.txt b/output/text/9adbbcb5-e4dd-4ef0-bf97-27fd0ac4b527.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a0f03d486a7a0cc4e8594232f782b0f62e0ef251
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+
+--- Page 1 ---
+SPECIMENS: A. SIGMOID COLON B. PROXIMAL DONUT C. DISTAL DONUT DIAGNOSIS: A.  SIGMOID COLON, SEGMENTAL RESECTION: INVASIVE MODERATELY DIFFERENTIATED ADENOCARCINOMA EXTENDING TO SUBSEROSA -TUMOR SIZE: 3.5x3.2x0.6 CM -ANGIOLYMPHATIC/PERINEURAL INVASION NOT IDENTIFIED. -EIGHTEEN LYMPH NODES NEGATIVE FOR TUMOR (0/18) -TUMOR ARISES IN TUBULAR ADENOMA -UNINVOLVED COLON SHOWS: HYPERPLASTIC POLYP AND DIVERTICULUM - SEE TEMPLATE B. COLON, PROXIMAL DONUT, EXCISION: COLONIC TISSUE, NO TUMOR SEEN. C.  COLON, DISTAL DONUT, EXCISION: COLONIC TISSUE, NO TUMOR SEEN. COLORECTAL CANCER TEMPLATE Tumor Size (cm): 3.5x3.2x0.6 cm Histologic Type: adenocarcinoma Grade/Differentiation: moderate Invasion Depth: subserosa Invasion Vasc/Lymphatic: absent Invasion Perineural: absent Extension to Adj. Areas: no Margins: free Lymph Nodes: negative (0/18) Stage Pathology: T3 N0 Mx Precursor: present, tubular adenoma Non-neoplastic areas: hyperplastic polyp, diverticulum SPECIMEN(S): A. SIGMOID COLON B. PROXIMAL DONUT C. DISTAL DONUT CLINICAL HISTORY: None GROSS DESCRIPTION: A.  SIGMOID COLON Received fresh is a 20.Ocm. segment of colon with both margins received stapled closed measuring. 4.5cm. in diameter and 5.Ocm. in diameter. The attached portion of pericolic fat measures 20.0x6.5x2.5cm. Upon opening, the mucosa shows a 3.5x3.2x0.6cm. pink tan ulcerated exophytic polypoid mass located 6.8cm. from the wide margin and 11.0cm. from the narrower margin. Remaining colonic mucosa is pink tan and smooth with a single diverticulum located 2.5cm. from the narrow margin. The tumor is noted to extend into the fat but not to the peritoneal surface. The radial margin of. resection is free of any lesion. The peritoneal surface of the tumor and the margins are marked by black ink. No discrete nodule lesion is identified in the pericolic fat. Multiple small lymph nodes are. identified ranging in size from < 0.1cm to 1.0cm. Representative tissue is submitted in nineteen cassettes as follows: A1: 4.5cm. shaved margin A2: 5.0cm. shaved margin A3: mass with deep margin A4: mass A5: mass with lymph nodes and fatty tissue
+
+--- Page 2 ---
+A6: one lymph node and deep fatty tissue contiguous with A5 A7-A8: mass A9: diverticulum A10: radial margin. A11: uninvolved colonic mucosa A12: five peritumoral lymph nodes A13; four peritumoral lymph nodes A14: two possible peritumoral lymph nodes A15: two possible peritumoral lymph nodes A16: five lymph nodes at narrow margin A17: four possible lymph nodes at narrow margin. A18: two lymph nodes at wide margin A19: one lymph node bisected at wide margin. B. PROXIMAL DONUT Received without fixative is a ring shaped 1.5x1.5x0.7cm. fragment of smooth, stapled colonic mucosa. with slight, focal pink red discoloration. The stapled part is removed and representative tissue is submitted in one cassette. C.DISTAL DONUT Received without fixative is a 1.5x1.5x1.0cm. ring shaped fragment of colonic mucosa with multiple. staples. The mucosa is tan, smooth with no discrete lesion. The stapled part is removed and the. remaining fragment of tissue is submitted in one cassette.
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diff --git a/output/text/9b09157a-6059-4b4f-96cb-73d964de34ef.txt b/output/text/9b09157a-6059-4b4f-96cb-73d964de34ef.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ce45b44af5914b5427aba60fb6176cd3cbf07342
--- /dev/null
+++ b/output/text/9b09157a-6059-4b4f-96cb-73d964de34ef.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Other Related Data: Billing Type: Financial Number: Clinical Diagnosis & History:. 7cm right renal mass.. Specimens Submitted: 1: SP: Right kidney and adrer. 2: SP: Paracaval lymph node DIAGNOSIS:E 1) KIDNEY/ADRENAL, RIGHT; NEPHRECTOMY: - RENAL CELL CARCINOMA, CHROMOPHOBE TYPE, EOSINOPHILIC VARIANT TUMOR MEASURES 6.3 CM IN GREATEST DIAMETER, AND INVOLVES THE UPPER POLE OF THE RIGHT KIDNEY. TUMOR INVADES THROUGH RENAL CAPSULE AND IS PRESENT WITHIN PERINEAL SOFT TISSUE (pT3a). - NO VASCULAR INVASION IS IDENTIFIED. BENIGN URETER AND VASCULAR MARGINS. SURGICAL MARGINS ARE FREE OF TUMOR. BENIGN ADRENAL. - BENIGN RENAL PARENCHYMA IS UNREMARKABLE. 2) PARACAVAL LYMPH NODE; EXCISION: - FOURTEEN BENIGN LYMPH NODES (O/14). IATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAI EXAMINATIO AND TWATIHAVE REVIEWED AND APPROVED THIS REPORT. Gross Description: 1) The specimen is received fresh, labeled "Right kidney and adrenal". It consists of a 880 grams of nephrectomy specimen. The specimen measures 23 x 10 x 8.5 cm. The specimen consists of kidney with surrounding perirenal soft tissue and attached proximal segment of the ureter. The right adrenal gland is also grossly identified at the upper pole of the specimen, measuring 4.2 x 2 x 0.9 cm. Grossly, a bulging renal mass is present at Page 1 of 2
+
+--- Page 2 ---
+the upper pole of the kidney. The specimen is bivalve along the ureter to reveal a relatively circumscribed tumor mass at the upper pole of the kidney measuring 6.3 cm in greatest diameter. The remaining kidney tissue measures 10 x 6.2 x 4 cm. The mass shows mosaic colors of brown, tan and grey area. The texture of. the tumor is rubbery. No definite necrosis is identified. Focal scar is also present. The tumor appears to bulge and invades. into the renal capsule. The tumor does not involve the renal. cavity. No vascular involvement of the tumor is identified. The attached ureter measures approximately 7 cm in length and 0.4 to. 0.5 cm in diameter. The proximal ureter shows dilated appearance and contains urine. The rest of the renal parenchyma is. unremarkable. The cut section of the adrenal is unremarkable. Representat ive sections are submitted. A portion of tumor is. sent for and a small portion is kept in glutaraldehyde. No fat. Summary of Sections:. - tumor R - random section of kidney. UM - ureteral margin VM - vascular margin ADR - adrenal 2) The specimen is received in formalin, labeled "Paracaval. lymph node". It consists of two irregular pieces of yellow-tan fibroadipose tissue, measuring 4.5 x 3.0 x 1.5 cm in aggregate,. possibly containing lymph nodes. The specimen is submitted entirely. Summary of Sections: U - Undesignated Summary of Sections:. Part Sect. SiteBlocks Pieces All 1 ADR 1 1 N R 1 1 T 9 9 UM 1 1 VM 1 1 2 U 6 M Y Page 2 of 2 END OF REPORT
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diff --git a/output/text/9b10ebec-fb41-4076-b4be-2cfa51834038.txt b/output/text/9b10ebec-fb41-4076-b4be-2cfa51834038.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7da689128e4e2e14ac881ac9ec07ac2861c9d790
--- /dev/null
+++ b/output/text/9b10ebec-fb41-4076-b4be-2cfa51834038.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:6D728871-8D6D-47B7-8A29-66870CA78A91 TCGA-WC-A881-01A-PR Redacted Accession: Specimen Date/Time:. TDO3 877z/3 DIAGNOSIS Sit D Chmwid C693 (A) LEFT GLOBE: CHOROIDAL MELANOMA, SPINDLE TYPE, 18 MM BASE 1/1w[14 Vortex veins, negative for tumor.. Optic nerve, negative for tumor.. Scleral invasion: absent (SEE COMMENT) COMMENT A PAS is reviewed which highlights internal structures. Mitotic count is less than 1 per 10 high-power fields.. GROSS DESCRIPTION (A) LEFT GLOBE - An intact left eye (23 x 22 x 21 mm) has an attached optic nerve (10 mm in length). The scleral area sl. fresh mark from prior FNA by surgeon. Extraocular lesions are not identified. The anterior chamber is clear formed by a 10 mm brown iris and shows a round 4.0 mm pupil. A large shadow is present on transillumination corresponding to a dark. brown-black pigmented mass arising in the choroidal region from 12-6 o'clock with an 18.0 mm base x 12.0 mm height, 6.0. from the optic nerve and does not involve the ciliary body. The sclera beneath the tumar is grossly intact. SECTiON CODE: A1-A4, vortex vein (superior nasal, superior temporal, inferior temporal, inferior nasal); A5, pupil-. nerve sections; A6, A7, calottes also with tumor. CLINICAL HISTORY Uveal melanoma. SNOMED CODES T-AA000, M-87203 "Some tests reported here may have been developed and performance characteristics determined by These lests have no specitically cleared or approved by the U.S. Food and Drug Administration." Entire report and diagnosis completed by: -END OF REPORT-
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diff --git a/output/text/9b20d483-2a2b-4a58-97c2-b0b2b2d95316.txt b/output/text/9b20d483-2a2b-4a58-97c2-b0b2b2d95316.txt
new file mode 100644
index 0000000000000000000000000000000000000000..23a174853e2dbf13eee84674c7cb9ea086970d91
--- /dev/null
+++ b/output/text/9b20d483-2a2b-4a58-97c2-b0b2b2d95316.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: FMP/SSN: DOB/Age/Sex: Specimen #: Location: Race: WHITE Physician(s) : Taken: Received: Reported: SPECIMEN: A: SENTINEL LYMPH NODE #1 B: RIGHT BREAST TISSUE 1cs-0-3 Carcin rma, nifilhnting ductel,Nos 85oy. Sih: bresst,'Nos c50.9 FINAL DIAGNOSIS: A. LYMPH NODE, SENTINEL #1, EXCISION: 1/as/n ISOLATED TUMOR CELLS IDENTIFIED. - SEE COMMENT B. BREAST, RIGHT, SIMPLE MASTECTOMY:  INFILTRATING DUCTAL CARCINOMA, MODERATELY DIFFERENTIATED (MODIFIED BLOOM RICHARDSON T=3, N=2, M1) TUMOR IS PRESENT WITHIN O.1 CM OF INFERIOR-ANTERIOR MARGIN (B19) TUMOR DIMENSION (GREATEST): 3.4 CM  NO DEFINITIVE LYMPH-VASCULAR INVASION IDENTIFIED. FIBROCYSTIC CHANGES INCLUDING STROMAL SCLEROSIS, CYST FORMATION,S AND APOCRINE METAPLASIA. - NIPPLE WITH NO SIGNIFICANT PATHOLOGICAL CHANGES - AJCC PATHOLOGIC STAGE: pT2, pNO(i+), Mx COMMENT : Isolated tumor cells and clusters (less than 0.2 mm in dimension) are identified in the lymph node capsule on H&E examination and confirmed by a positive pancytokeratin immunohistochemical stain.. ** Report Electronically Signed Out ** CLINICAL DIAGNOSIS AND HISTORY: year-old female with right breast cancer.  UUID: D503E730-8894-46A0-A24F-93069A56DC7D3 TCGA-A2-A0CU-01A-PR Redacted Page 1 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 Continued on Next Page.
+
+--- Page 2 ---
+FOR ORFICIAL USE OWLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION: A. Received in formalin, labeled with the patient's name, designated "SENTINEL LYMPH NODE #1" is a 2.0 x 1.0 x 0.5 cm yellow-white, soft tissue fragment. Bisected.. B. Received in fresh, labeled with the patient's name, designated "RIGHT BREAsT TIssuE" is a 441.0 gram, simple mastectomy specimen, oriented with sutures (short superior, long lateral) measuring. 20.0 x 15.5 x 3.2 cm. The overlying nipple/areolar complex measures 3.4. 2.5 cm. Ink code: blue = superior-anterior, green = inferior-anterior,. black = posterior. Sectioning reveals a 3.4 x 2.7 x 2.5 cm tumor with. firm, tan, focally hemorrhagic cut surface in the lower outer quadrant. The tumor grossly involves the anterior margin, and is approximately 2.0. cm from the posterior margin. The remaining tissue is mostly fatty with admixed patches of white, fibrous tissue. This tissue is centrally adjacent to the tumor. Multiple tissue sections submitted for cBcp protocol with matching paraffin sections as follows: Slide key: Bl: Skin B2: Tumor with anterior margin. B3: Tumor with anterior margin. B4: Grossly normal fibrous, central, 2.0 cm from the tumor. B5: Representative nipple. B6-B7: Representative upper outer quadrant.. B8-B9: Representative lower outer quadrant.. B10-B1l: Representative upper inner quadrant.. B12-B13: Representative lower inner quadrant. B14-B15: Representative tumor. B16-B19: Representative tumor. 19CF Page 2 End of Report. FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
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diff --git a/output/text/9b3076af-64d4-492e-98f5-b6cd402b1411.txt b/output/text/9b3076af-64d4-492e-98f5-b6cd402b1411.txt
new file mode 100644
index 0000000000000000000000000000000000000000..63ce2ee8bc0ac6dea204f53f83b9f79d5e09c589
--- /dev/null
+++ b/output/text/9b3076af-64d4-492e-98f5-b6cd402b1411.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+****** Resident: Pathologist: PATHOLOGIC DIAGNOSIS: A. SPECIMEN DESIGNATED "PERIGASTRIC LYMPH NODES": Heterotopic pancreas with focal pancreatic intraepithelial neoplasia type 1 (PanIN1) No lymph node is present. B. SPECIMEN DESIGNATED "RIGHT COLON, HEMICOLECTOMY": MUCINOUs ADENOCARCINOMA, low grade, moderately differentiated (7.0 cm in greatest dimension). The tumor forms a fungating mass and has an infiltrating border. The tumor invades through the subserosa to the serosal surface.. The proximal, distal, and radial resection margins are negative. for tumor. Invasive tumor is 152mm from the proximal resection margin, 206mm. from the distal resection margin, and 21mm from the radial resection margin. Lymphovascular invasion is not identified. Venous invasion is not identified. Perineural invasion is not identified. Peritumoral lymphoid response (including Crohn'slike infiltrate) is mild. Residual adenoma is present. Regional lymph nodes. (positive:total): 5:31 AJCc Classification T4 N2 MX. CLINICAL DATA: History: None provided. Operation: Laparoscopic converted to open right hemicolectomy. Operative Findings: None provided. Clinical Diagnosis: Colon cancer. TISSUE SUBMITTED: A/1. Perigastric lymph node. B/2. Right hemicolectomy to Fs. GROSS DESCRIPTION: The specimen is received fresh, in two parts, each labeled with the patient's name and medical record number. Part A, "#1. Perigastric lymph node", consists of a red/brown fibroadipose tissue fragment (2.5 x 1.5 x'1.0 cm)'containing a single lymph node. The specimen is entirely submitted. Micro A1-A2: Lymph node, bisected, 1 frag per cassette, Part B, "#2. Right hemicolectomy", consists of a hemicolectomy specimen (37.5 x 7.5 cm), including an appendix (7.0 x 0.5 cm) and the distal ileum (3.0 x 2.0. cm), which includes a stapled resection margin (blue, 2.0 cm) and a distal stapled resection margin (black, 2.8 cm). There is a fungating tan/red mass (7.0 x 4.0 x 2.3 cm), which measures 12.6 cm to the ileocecal valve, 15.2 cm to the proximal stapled resection margin, 20.6 cm to the distal stapled resection margin, and 2.1 cm to the radial margin. There is a second tan/yellow polyp Page: 1 of 2
+
+--- Page 2 ---
+Pathology Report (0.3 cm in diameter), which measures 4.0 cm to the distal stapled resection No other lesions margin and 33.0 cm to the proximal stapled resection margin. are identified.  Representative sections of the tumor and normal bowel are submitted to the tissue bank.  Representative sections of x 1.9 x 1.6 cm) are identified in the mesentery. the larger two lymph nodes are submitted.  The remaining lymph nodes are entirely submitted. Micro Bl: Proximal stapled resection margin,  frag frag, Micro B3: Radial resection margin, 1 frag,. Micro B4: Tumor with serosal involvement 1 frag, Micro B5: Additional tumor, 1 frag, 1 frag Micro B6: Tumor with proximal adjacent mucosa, Micro B7: Tumor with distal adjacent mucosa,. frag, Micro B8: Polyp and normal mucosa,  frags, Micro B9: Appendix, tip and perpendicular distal end,. 4 frags Micro Bll: Largest candidate node, 1  frag, Micro B13: Third largest node, 2 frags. Micro, B14: Candidate node, 2 frags, Micro B15-B17: Candidate nodes, ? frags per cassette,. By his/her signature below, the senior physician certifies that he/she pexsonally conducted a microscopic examination ("gross only" exam if so stated) of the described specimen(s) and rendered or confirmed the diagnosis(es) related thereto. Diaqnosis by. Electronically signed on ADDENDUM: Immunostains for MLh1, Msh6, Pms2, and Msh2 reveal intact nuclear staining in tumor cells. In a very small percentage of tumors, there is an underlying hereditary genetic defect despite intact nuclear expression in tumor cells. Clinical correlation is required. Addendum #1 by Electronically signed on Page: 2 of:
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diff --git a/output/text/9b3a96bb-e54c-4a75-ba70-12e5923bb3f2.txt b/output/text/9b3a96bb-e54c-4a75-ba70-12e5923bb3f2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..19e94a4e48212fbceb9c355d059f0049ba01e415
--- /dev/null
+++ b/output/text/9b3a96bb-e54c-4a75-ba70-12e5923bb3f2.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:D76CF03A-54CD-4769-87AA-466473F41FC7 Page 1 of 3 TCGA-B6-A401-01A-PR Redacted Patient AP Surgical Pathology: Additional Info Surg Path CLINICAL HISTORY: Not provided. GROSS EXAMINATION: : A. "Sentinel node #1, hot (AFl-3)", received for frozen section are three lymph node candidates..  One lymph node is bisected and submitted for frozen section as AFl-AF2, and the remnant sections are submitted in blocks A1-2. Two additional lymph nodes are submitted for frozen section as AF3, and the remnant is submitted as block A3. B. "Axillary fat", received in formalin is a 11.3 x 4 x 1.5 cm fragment of yellow-tan adipose tissue which is dissected to reveal one lymph node candidate measuring 0.8 x 0.7 x 0.5 cm, which is submitted entirely in block B1. C. "Left breast cancer, two clips medial, one clip inferior, long stitch lateral, short stitch superior", received in formalin is a 8 cm medial to specimen inked as follows: superior-yellow, inferior-red, anterior-blue and. posterior-black. The specimen is sectioned from medial to lateral to reveal a 2.0 x 1.5 x 1 cm mass lesion located 0.4 cm from the posterior margin, 0.7 cm from the anterior margin, 2.7 cm from the medial margin, 2.7 cm from the lateral margin, 1.3 cm from the superior margin and 3.2 cm from the superior margin. The remainder of the breast tissue demonstrates fibrofatty lobulated adipose tissue that is otherwise grossly unremarkable. Sections are submitted as follows per the block diagram: BLOCK SUMMARY: 1cD-o-3 carcinoma,inF1+aHng ducfa1NO5 C1- medial edge C2-4 representative medial breast 8soo/3 C5-28  mass submitted entirely Si+:brcast,N0S c5O.9 c29-31 representative lateral breast c32-34 lateral edge 7-Z-iz cD D. "Superior medial margin", received in formalin is a 7.2 x 6.4 x 2.3 cm fragment of adipose tissue with a stitch marking final margin. The final margin is inked blue and the opposite margin is inked black. Every other section is submitted in blocks Dl-10. E. "Medial and superior margin", received in formalin is a 5.5 x 3.5 x 2.2 cm fragment of yellow-tan adipose tissue with a stitch in place marking the final margin. The stitched margin is inked blue, and the opposite margin is inked black. The specimen is sectioned to reveal no focal lesions. Every other section is submitted in blocks E1-12. F. "Inferior to lateral margin", received in formalin is a 6.5 x 5.2 x 2.1 cm fragment of yellow-tan adipose tissue with a suture marking the final margin. The final margin is inked blue and the opposite margin is inked black. The specimen is sectioned to reveal no focal lesions. Every other section is submitted in blocks F1-11. G. "Anterior skin", received in formalin is a 7.5 x 5 x 2 cm unoriented aggregate of brown skin with subcutaneous tissue that is grossly unremarkable. Representative sections are submitted in blocks G1-3. INTRA OPERATIVE CONSULTATION: "Sentinel node #1, hot and blue": A.
+
+--- Page 2 ---
+Page 2 of 3 AF1-2 (one lymph node candidate, bisected)-positive for carcinoma.. AF3 (two lymph node candidates)-negative for malignancy MICROSCOPIC EXAMINATION: Microscopic examination is performed.. PATHOLOGIC STAGE: PRoceDuRe: Partial mastectomy, sentinel lymph node biopsy. PATHOLOGIC STAGE (AJCC) Edition): pT1c pNla(sn) pMX NoTe: Information on pathology stage and the operative procedure is. transmitted to this Institution's Cancer Registry as required for accreditation by the Conmission on Cancer. Pathology stage is based solely. upon the current tissue specimen being evaluated, and does not incorporate information on any specimens submitted separately to our Cytology section, past pathology information, imaging studies, or clinical or operative. findings. Pathology stage is only a component to be considered in determining the clinical stage, and should not be confused with nor substituted for it. The exact operative procedure is available in the surgeon's operative report. DIAGNOSIS: A. "SENTINEL LYMPH NODE #1" (BIOPSY) : METASTATIC ADENOCARCINOMA IN ONE OF THREE LYMPH NODES (1/3). SIZE OF METASTASIS: 5 MILLIMETERS EXTRANODAL INVASION: ABSENT. B. "AXILLARY FAT" (EXCISION): ONE LYMPH NODE, NO EVIDENCE OF MALIGNANCY (O/1).) SEE COMMENT. COMMENT :  The specimen is re-examined and only one lymph node is identified.. C. "LEFT BREAST CANCER" (PARTIAL MASTECTOMY) : INVASIVE ADENOCARCINOMA OF THE BREAST.S HISTOLOGIC TYPE: DUCTAL. NOTTINGHAM COMBINED HISTOLOGIC GRADE: 3 OF 3. TUBULE FORMATION SCORE: 3 NUCLEAR PLEOMORPHISM SCORE: 3 MITOTIC RATE SCORE: 2 GROSS TUMOR SIZE: 2 X 1.5 X 1 CM. SIZE OF INVASIVE COMPONENT: 2.0 CM. LYMPHATIC/VASCULAR INVASION: ABSENT. MULTIFOCAL TUMOR: ABSENT. IN-SITU CARCINOMA: PRESENT. TYPE OF IN-SITU CARCINOMA: CRIBRIFORM.S NUCLEAR GRADE OF IN-SITU CARCINOMA: 3 OF 3. NECROSIS: ABSENT. DCIS EXTENDING OUTSIDE INVASIVE TUMOR MASS: ABSENT. SIZE OF IN-SITU CARCINOMA: NOT APPLICABLE. STATUS OF NON-NEOPLASTIC BREAST TISSUE: INTRADUCTAL PAPILLOMA, RECENT NEEDLE CORE BIOPSY SITE. SIZE OF BIOPSY: 8 X 7 X 2.7 CM. MICROCALCIFICATIONS: ABSENT. SURGICAL MARGIN STATUS: NEGATIVE (GREATER THAN 2 MM).) ESTROGEN/PROGESTERONE RECEPTOR, CELL CYCLE, EGFR AND HER2/NEU ANALYSIS: PENDING.
+
+--- Page 3 ---
+Page 3 ot 3 PARAFFIN BLOCK NUMBER: C14. RESULTS WILL BE ISSUED IN SEPARATE REPORT FROM D. "SUPERIOR MEDIAL MARGIN, LEFT BREAST" (RE-EXCISION) : BREAST TISSUE, NO EVIDENCE OF MALIGNANCY. FINAL MARGIN FREE OF TUMOR. E. "MEDIAL AND SUPERIOR MARGIN, LEFT BREAST" (RE-EXCISION) : BREAST TISSUE, NO EVIDENCE OF MALIGNANCY. FINAL MARGIN FREE OF TUMOR. F. "INFERIOR TO LATERAL" (RE-EXCISION) : BREAST TISSUE, NO EVIDENCE OF MALIGNANCY. FINAL MARGIN FREE OF TUMOR. G. "ANTERIOR SKIN" (BIOPSY) : SKIN AND SUBCUTANEOUS TISSUE, NO EVIDENCE OF MALIGNANCY. FINAL MARGIN IS NEGATIVE FOR MALIGNANCY. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es). Electronically signed: : ADDENDUM 1: Please see for results of supplementary tests. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es). Electronically signed: Performed by:
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diff --git a/output/text/9b7da97f-d947-47bd-9228-dad4ca03b25d.txt b/output/text/9b7da97f-d947-47bd-9228-dad4ca03b25d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7b1baa7390cd70560795416850935e989660f87f
--- /dev/null
+++ b/output/text/9b7da97f-d947-47bd-9228-dad4ca03b25d.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Patient Name: IcD-o-3 Sex: Female Carcinorio, Adrenal CsrticaI Redacted 837d|3 Site: BAdrenal Glard Cortex C74 Z yl i/3o)3 Macroscopy Two vessel containing a material immersed in formaldehyde solution, described as following: 1. Right. adrenal mass, weighting 1370 g and measuring 20 x 13 x 7 cm, with a grayish and homogeneous. external surface. The cut surface is heterogeneous, characterized by white areas and purple areas with a firm consistency. Fragment of a rib bone, measuring 15 x 3 cm with an habitual aspect. 2. Hepatic. biposy -- an irregular dark brown fragment measuring 2 x I cm.. Conclusion: 1. Product of right nephrectomy and right adrenal mass resection: Adrenocortical carcinoma with the. following features: :Largest diameter -- 20 cm. Nuclear grade (Fuhrman) -- 3-  Diffuse architectural pattern -- present Clear cells in < 25% of the neoplasm -- present Areas on necrosis -- not detected Mitotic count -- 5 in 50 H.P.F. Atypical mitosis -- not detected Capsular invasion -- not detected .Venous invasion -- not detected Sinusoidal invasion -- not detected WEISS SCORE - 3
+
+--- Page 2 ---
+Renal parenchyma without evidence of neoplastic infiltration 2. Liver biopsy -- Hyperplastic regenerative nodule. Immunohystochemical markers: Melan A - focally positive Inhibin -- positive 35BH11 -- focally positive cytokeratin 20 -- negative cytokeratin 7 -- negative  Sinaptofisin -- negative Hep-Par I -- negative Chromogranin -- negative CEA -- negative Calretinin -- negative
\ No newline at end of file
diff --git a/output/text/9ba05841-185f-4e8b-b410-1e30fd16d81e.txt b/output/text/9ba05841-185f-4e8b-b410-1e30fd16d81e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2e4ad2c0bc2f1c5b8441964fab68fd2684431040
--- /dev/null
+++ b/output/text/9ba05841-185f-4e8b-b410-1e30fd16d81e.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Jcs-0-3 CaLcn onu,mfiIn#nj cuctl n0s 85oof3 Site : brsof, nos c50.9 page 1 / 1 Department of Cancer Pathologye copy No. Date: Examination: Intraoperative examination Internal invoice No. Cost of diagnostic procedure Examination No.: Patient: xXX PEseL: XXX Age: Gender: F Material: Leslon excision -- Lesion in the left breast -- outer upper quad. Unit in charge Physician in charge: Material collected on Iterial received on Expected time of examination: 20 minutes (from receipt of material) Clinical diagnosis: Cancer of the left breast. Examination performed on: - Result of intraoperative examination:. Carcinoma invasivum Compliance validated by: Examination performed on: Macroscopic description: Fragment of the breast sized 6 x 5 x 2 cm.. Tumour sized 1.2 x 0.8 x 0.7 cm in the middle. Minimum margin: 1 cm. Histopathological diagnosis: Carcinoma ductale invasivum NHG3 (3 + 3 + 2/10 mitoses/10 HPF - visual area 0.55 mm). pT1c Invasive ductal carcinoma of the left breast. Compliance validated b, Examination performed on Results of immunohistochemical examination: No estrogen receptors found in neoplastic cell nuclei. No progesterone receptors found in neoplastic cell nuclei. HER2 protein stained with HercepTestTM by DAKO. Negative reaction in invasive cancerous cells ( Score = 1+ ) Compliance validated by: UUID:03724E51-8430-414F-B483-2C392D6A878F TCGA-D8-A13F-01A-PR Redacted
\ No newline at end of file
diff --git a/output/text/9c17aab5-6185-467e-9d88-8e0b57233a54.txt b/output/text/9c17aab5-6185-467e-9d88-8e0b57233a54.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d7deb2d08aa9af24ad82419cc437da4d63b80250
--- /dev/null
+++ b/output/text/9c17aab5-6185-467e-9d88-8e0b57233a54.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:9AF70357-D696-4AEB-B338-7A711A 39DAES TCGA-ZF-A9RE-01A-PR Redacted Specimen Comments SPECIMEN Bladder tumour. CLINICAL DETAILS Samples taken for research. Persistent G3 pT2 TCC. MACROSCOPY 18g of firm and friable tissue chippings. MICROSCOPY Grade: 3 poorly differentiated. Growth pattern: Mixed papillary and solid. Type: Transitional cell carcinoma. Muscularis propria present: Yes. Stromal invasion: Invasion of muscularis propria (at least). Vascular channel invasion: No definite lymphovascular invasion.. Background urothelium: Carcinoma in situ is present in flat urothelium. Summary: Transitional cell carcinoma G3 pT2 (at  least). Pathologists - Ic-0-3 C&Le lprunorD,wwtuLesQ NsS 8/3c/3 'areinoms, taroiLimal cQl N0S 812c/3 Sut; MlasderNos Cb7.9 QJ 5/Q|14
\ No newline at end of file
diff --git a/output/text/9c246efa-1faa-474d-b824-766eca7077cf.txt b/output/text/9c246efa-1faa-474d-b824-766eca7077cf.txt
new file mode 100644
index 0000000000000000000000000000000000000000..68168b6d9a62f0ecc7cae1bf34dac431d60578ba
--- /dev/null
+++ b/output/text/9c246efa-1faa-474d-b824-766eca7077cf.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID: BC7B3577-CA6C-41AD-98E2-89D357D29D37 edacted Final Diagnosis Weast, left, wide local excision: Invasive ductal carcinoma, Nottingham grade III (of III), forming a 2.7 x 2.7 x 1.5 cm mass (AJCC pT2). The margins, including the separately submitted superior margin, are negative for tumor. The closest margin (superior) is free by 1.5 cm. Lymph nodes, left axillary sentinel, excision: Multiple (2) left axillary sentinel lymph nodes are negative for tumor [AJCCpN0 (i- sn)]. Blue dye is identified in both left axillary sentinel lymph nodes. Immunohistochemical cytokeratin stain was performed on the paraffin embedded sentinel lymph node tissue and confirms the H&E impression. /cs -0-3 Chi omu, nifItratiny duct,N0s850o/3 Sih : busf Nos c50.9
\ No newline at end of file
diff --git a/output/text/9c56035e-9e97-475d-9dc6-8f1329cd2c8d.txt b/output/text/9c56035e-9e97-475d-9dc6-8f1329cd2c8d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..684f5af24cda71884930b397fa7acf78ee81e825
--- /dev/null
+++ b/output/text/9c56035e-9e97-475d-9dc6-8f1329cd2c8d.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Requested by: Patient MRN DOB ted UUID: DE38B130-FD4D-4077-ADBE-D034C2F5F003 Reda Date of Service TCGA-FV-A2QR-01A-PR Performing Facility. Ordering Provider Resuit Provider Report Name. :Surgical Report Status : x GALLBLADDER SURGICAL PATHOLOGY REPORT PROCEDURE DATE: SPECIMEN DESCRIPTION: A. GALLBLADDER B. INTRALUMINAL BILE CUCT TUMOR /cs -0-3 C . LEFT LOBE. LIVER. CPC taciume, hepatocllule, NoS 0. BILE DUCT MARGIN 5170f3 * PRE-OPERATIVE DIAGNOSIS: Cholangiocarcinoma Site: hir CJ2.0 -* POST-OPERATIVE DIAGNOSIS: h 9/3|1 Same ** CLINICAL INFORMATION: None provided =INTRAOPERATIVE CONSULTATION:  CPC DiAGN0sis: "Tissue submitted for genomics study: margin inked" by - GROSS DESCRIPTION: A. The specimen consists of a gallbladder. measuring 7.0 cm in length x 3.0. cm in greatest external diameter. The cystic duct is not present. *The opening is irregular and measures 1.0 x 0.6 cm. Approximately 0.5 cm away from the irregular opening. there is a transmural mechanical defect, measuring. 2.0 x 1.2 cm. The serosa1 surface is smooth and tan-pink. The gallbladder is inked black and serially sectioned. The mucosal surface is congested and slightly rough. No discrete mass or ulceration is present. The specimen is serially sectioned and no discrete lesion is identified. The wall measures 0.3 cm in thickness. No lymph node is identitied externally. Separately received in the same container are two irregular tan-brown calculi. each measuring 0.6 x 0.5 x 0.4 cm. On sectioning. the calculi are composed of tan-brown friable material. Representative sections are submitted in four cassettes as follows: cassette 1 - opening: cassettes 2 through 4 - random sections. B. The specimen consists of one portion of irregular tan-pink soft tissue measuring 1.4 x 0.6 x 0.5 cm. The external surface is rough. No discrete mucosa is visualized. The entire external surface is inked black and the specimen is serially sectioned. The sections show tan-white firm tissue. The specimen is totally submitted in one cassette. C/cpc. The specinen consists of the left lobe of liver and measures 9.5 x 9.0.
+
+--- Page 2 ---
+Requested by: Patient MRN DOB Date of Service. Performing Facility Ordering Provider. Result Provider Report Name :Surgical Report. Status :F DXSTIC x x 6.0 cm. The specimen weighs 390 grams. The capsular surface is tan-brown.. with multiple irregular bosselated tan-white areas. measuring up to 2.0 x 1.5 cm on the superior surface and the inferior surface. The surgical resection surface reveals tan-brown cauterization. Immedrately adjacent to the surgical resection surface, there is a segment of left hepatic bile duct. measuring 2.8 cm in length x 0.6 cm in diameter. The dista! end of the hepatic bile duct is marked by a blue suture. The hepatic duct has been opened by the surgeon. Approximately 1.7 cm proximal to the surgical resection margin. there is an adherent. intramural mass, measuring 0.8 x 0.6 x 0.3 cm. (Please note: In the sections. the tumor appears to be on the outside of the hepatic bile duct). The iiver is serially sectioned and approximately 85% of the specimen is replaced by an irregular tan-white mass. measuring 9.0 x 7.0 x 5.5 cm. The mass is composed of lobulated tan-white firm tissue with focal hemorrhage. The remaining portion of the specimen shows tan-brown hepatic parenchyma with multiple small satellite lesions. measuring up to 0.6 cm in greatest dimension. The surgical resection margin is o.1 cm away from the mass. Multiple intraparenchymal bile duct lumina are campletely occluded by the tan-white firm tumor tissue. Representative sections are submitted in nine cassettes as follaws: cassette 1 - hepatic bile duct margin: cassettes 2 and 3 - possible adherent intraluminal tumor: cassette 4 - surgical resection margins. of the liver; cassettes 5 through 8 - mass: cassette 9 - satellite lesions. D. The specimen consists of one portion of irregular tan-pink soft tissue. measuring 1.3 x 0.6 x 0.3 cm. The external surface is shaggy. The specimen cannot be oriented. The entire specimen is submitted intact in one cassette. * MICROSCUPIC DESCRIPTION: : A. The gallbladder is appreciably thickened with prominent chronic inflammation and extensive thickening of the muscularis as well as thickening of the serosa. It is congested. No tumor is seen.. B. This consists of tumor without presence of uninvolved tissue. Sheets and nests of cells have small to medium sized nuclei which are slightly irregular in contour. The cells have predominantly vacuolated cytoplasm. In other areas it is eosinophilic with little or no vacuolization. Some areas have increased fibrous stroma. C/cPc. Tumor is present and similar to that previously described. This frequently has: intervening zones of fibrosis. It consists predominantly of sheets of cells with mostly clear cytoplasm. Some areas have a somewhat trabecular arrangement with a slight suggestion of attempted gland-iike formation however this is not well developed. No tumor is seen at the inked. margins. Tumor is present within ductal lumina in slides 7 and 8. The
+
+--- Page 3 ---
+/311 Requested by: Patient MRN DOB Date of Service Performing Facility Ordering Provider Resuit Provider Report Name :Surgical Renort Status :F x adjacent hepatic tissue has regions of chronic inflamnation. Portal fibrosis is present.  Cirrhosis is not seen.. D. ' This consists of fibrous tissue with some adipose tissue. Areas of ducts are present within the fibrous tissue. No tumor is seen. --= SPECIAL STAINS: Special stains have been performed on block 4. . No definite tumor cells have positive staining for CA19.9. Where present, it is conststent with residual hepatic ductular elements. The tumor is also negative for pancytokeratin (AE1/Ae3). Where present. positive staining is consistent with residual ducts. Additional special stain results follow. There is staining of two of three portions of tumor for Ck7 and staining for Ck20 predominantly in two of three portions of tissue with some staining in the third piece. Only small numbers of tumor cells have staining for HepPar-1. There is strong staining for CK8/18 (CAM5.2). Staining for vimentin is present within some tumor cells. There is strong staining for alphal-AT in all tumor cells.. uAGNOSIS: A. GALLBLADDER: CHRONIC CHOLECYSTITIS WITH CHOLELITHIASISS 8. INTRALUMINAL MASS OF BILE DUCT: HEPATOCELLULAR CARCINOMAS C/CPC. LEFT LOBE OF LIVER, RESECTION: 1. HEPATOCELLULAR CARCINOMA 2. HISTOLOGIC GRADE: GRADE I 3. PATHOLOGIC STAGING: pT1 4. REGIONAL LYMPH NODES: pNX 5. DISTANT METASTASIS: pMX 6. MARGINS: UNINVOLVED BY CARCINOMA 7. BILE OUCT MARGIN: FREE OF TUMOR 8. SMALL SATELLITE TUMOR 0.  BILE DUCT MARGIN: FREE OF TUMOR A-MAI IGNANT (ETectronic Signature) - PATHOLOGIST CUMMENT: The tumor invades bile ducts but has the morphologic pattern of hepatocellular. carcinoma. The lack of elevation or staining for AFP does not mitigate. against the diagnosis of hepatocellular carcinoma because this is seen in only approximately 30% of hepatocellular carcinomas. No cirrhosis is seen..
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diff --git a/output/text/9c6f4e25-8225-48fa-be58-6d4ea0e4c8b3.txt b/output/text/9c6f4e25-8225-48fa-be58-6d4ea0e4c8b3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e50898cb93b1fbe81065f76feee88c66584720ff
--- /dev/null
+++ b/output/text/9c6f4e25-8225-48fa-be58-6d4ea0e4c8b3.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SPECIMENS: A. LEFT COLON SPECIMEN(S): A. LEFT COLON INTRAOPERATIVE CONSULTATION DIAGNOSIS: A-left colon: Tumor mass is 9 cm away from the distal margin, called by. GROSS DESCRIPTION: A. LEFT COLON Received fresh labeled with the patient's identification and "left colon" is a 24 cm segment of colon with circumference of 7.5 cm with a suture designating the distal margin. The serosa is unremarkable. The mesocolon and serosa, subjacent to the mass, is inked black. A 9 x 6.5 x 3cm circumferential, polypoid, indurated, necrotic mass is present, 9 cm from the distal margin, involving the subserosal fat. Proximal mucosa has diverticuli and 3 polyps, 0.2 cm, 0.3 cm, and 0.5 cm. A gross assessment is conveyed to O.. R., a photograph is taken, and tissue is procured. Representatively submitted: A1: shave of proximal margin A2: shave of distal margin A3-A8: mass A9: possible diverticuli A10: polyps A11: normal appearing mucosa extending into flattened mucosa. A12-A13: proximal, 6 possible lymph nodes in each cassette A14: proximal, 1 lymph node A15-A16: distal, 6 possible lymph nodes in each cassette. A17: distal, 4 lymph nodes DIAGNOSIS: COLON, LEFT, RESECTION: - INVASIVE MUCINOUS ADENOCARCINOMA, MODERATELY DIFFERENTIATED, ARISING IN A TUBULOVILLOUS ADENOMA - TUMOR MEASURES 9 X 6.5 X 3 CM. - TUMOR INVOLVES THE SUBSEROSA. - MARGINS, FREE OF TUMOR. - METASTASTIC CARCINOMA IN TWO OF 26 LYMPH NODES (2/26) - TWO TUBULAR ADENOMAS. - DIVERTICULOSIS. NOTE: On slide A3, mucin with fibrosis and marked inflammation is seen at an inked radial aspect that is fragmented. Tumor is not definitely identified at the radial margin. Dr. concurs. Clinical-surgical correlation is recommended. SYNOPTIC REPORT - COLON & RECTUM Specimen Type: Left hemicolectomy Tumor Site: Left (descending) colon Tumor Configuration: Exophytic (polypoid) Infiltrative Tumor size: 9cm Additional dimensions 6.5cm x 3cm WHO Classification Mucinous adenocarcinoma 8480/3 Histologic Grade: G2: Moderately differentiated Extent of Invasion:  Subserosa Margins: Margin(s) uninvolved by invasive carcinoma (Proximal, Distal, Radial).  Venous/Lymphatic Invasion: Present Perineural Invasion: Absent Additional Pathologic Findings: Adenoma Extent of Resection:  Ro: Complete resection with grossly and microscopically negative margins Lymph Nodes: Positive 2 / 26 Extranodal extension: Absent
+
+--- Page 2 ---
+Implants:  Absent Pathological Staging (pTNM):  pT 3 N 1 M X CLINICAL HISTORY:  None given PRE-OPERATIVE DIAGNOSIS: Colon cancer
\ No newline at end of file
diff --git a/output/text/9c8e74a5-a645-4dcd-9902-6021117b5b6d.txt b/output/text/9c8e74a5-a645-4dcd-9902-6021117b5b6d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0df51b102fce0df2849c2ca083ebdb0c87958ebc
--- /dev/null
+++ b/output/text/9c8e74a5-a645-4dcd-9902-6021117b5b6d.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:8BF174B0-88E5-4F9A-841C-12B43AC191B8 -A88W-01A-PR Redacted CGA-L5 PREVIOUS DIAGNOSIS INQUIRYE PAGE #: 5 REPORT DATE: NAM PATIENT NBR: SEX: M BIRTHDATE: ADM DATE: OPER DATE: AcCEssIOn: REQ DOC: PROCEDURE: VERIFIED BY: -year-old male with has long history of achalasia. Operative Procedure/Tissue Submitted: Transhiatal esophagectony, J-tube placement. Cervical esophageal margin free; non-stapled margin. Wants to know if there is malignancy. PROCEDURE: VERIFIED BY: 1. #Non-stapled margin, cervical esophageal margin." Received fresh. in a smal! container is a 3.0 x 2.0 x 1.2 cm strip ot mucosa. The mucosa is tan-grey and stightly granular with submucosal hemorrhages. The non-stapled end is shaved. 1A. Shaved margin. Frozen section control.. 2. *Proximal stomach and esophagus." Received in formalin in a large container is a 17.5 cm long segment of esophagus with a 6.2 x 3.2 x 1.5 cm portion of proximal stomach. The adventitia and red and ragged with a defect noted 2 cm away from the proximal margin. A friable grey-tan tissue is extending from the defect. The esophagus is dilated to internal circumference of 13.3 cm that narrows at the. esophagogastric junction with an internal circumference of 2.8 cm. The mucosa of the esophagus is granular grey-white, thickened, somewhat rugated mucosa with areas of granular grey-white scaly tissue. It is remarkable for a 5.2 x 4.3 x 2.2 cm red-grey verrucoid tumors that is 0.1 cm away from the proximal margin. It is also located at the aforementioned perforation. The proximal margin is inked blue. Tumor .is extremely friable. The tumor has a maximum depth of 0.2 cm and extends to the adventitia within the area of the perforation. Multiple possible lymph nodes are identified. They range up to 1.0 cm. 2A - 2c. Tumor to proximal margin. 2D and 2E. Tumor to deep and perforation. 2F - 2N. A strip from proximal to most distal with the proximal end inked blue. 20 - 2x. A second strip of esophagus from proximal esophagus to distal margin.. Proximal end is inked blue. 2Y. Granular scaly esophageal mucosa.. 2z. Possible lymph nodes. Photographs have been taken.. 3. "Cervical paraesophageal lymph nodes." Received in formalin in a small container is a 1.7 cm lymph node. Bisected. 4. "Cervical lymph node." Received in formalin in a smatl container is a 0.4 cm portion of yellow soft tissue. 5. "Gastrosplenic lymph node." Receivea in formalin in a small container is a 0.6 cm portion of arey-yellow soft tissue. Definite lymph nodes not identitied. tcD-o-3 Arcurono, sgeemsee) CIL 8B7Of3 Sute Owtol tuoly esophogs) C/SS 0 Astresey phagsljunctv C14.D HJ 11/iz/13
+
+--- Page 2 ---
+PREVIOUS DIAGNOSIS INQUIRYS REPORT DATE: PAGE #: 6 PATIENT NBR: SEX: M NAME: BIRTHDATE: ADM DATE: OPER DATE: REQ DOC: ACCESSION: FROZEN SECTION REPORTS 1. Squamous hyperplasia. Negative for carcinoma. have reviewed and interpreted the frozen section I, material at the time it was requested. Permanent sections contirm frozen section report. PROCEDURE: VERIFIED BY: ESOPHAGEAL, CARDIAC AND GASTROESOPHAGEAL JUNCTION CARCINOMA: Type of carcinoma: Squamous cell carcinoma. Depth of invasion: Adventitia.. Number of positive lymph nodes: 0/8 Extranodal metastasis: Unknown. Pattern of invasion: Infiltrative. Esophageal and gastric resection margins involved: No. Deep resection margin involved: Yes. TNM classification: T3 NO Mx PROCEDURE: VERIFIED BY: 1. Cervical esophageal margin, intraoperative biopsy: Squamous hyperplasia, no. invasive carcinoma.. 2. Proximal stomach and esophagus, resection: Transmurally invasive well-differentiated squamous cell carcinoma extending to the deep (radial) margin of resection. Six lymph nodes negative for neoplasm. Squamous hyperplasia, chronic inflanmation and lack of ganglion cells-consistent with. achalasia. 3. Cervical paraesophageal lymph nodes, excision: One lymph node negative for. neopl asm.
+
+--- Page 3 ---
+PREVIOUS DIAGNOSIS INQUIRYE REPORT DATE: PAGE #: NAME: PATIENT NBR: SEX: M BIrTHDATE: : ADM Date: ACCESSION: OPER DATE: REQ DOC: 4. Cervicat lymph node, excision: One lymph node negative for neoplasm. 5. Gastrosplenic lymph node, excision: Benign fibroadipose tissue. I, the signing staff pathologist, have personally. examinea anu ms.p.w.rd the slides from this case.. Code:
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diff --git a/output/text/9cb95a20-e904-4f71-bb18-488c843ecc98.txt b/output/text/9cb95a20-e904-4f71-bb18-488c843ecc98.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7acf2ff4218abbea53679541a747b4fa00cf0454
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TCGA-DZ-6135 Surgical Pathology. REVISED REpORT (Revised information underlined) TISSUE DESCRIPTION: Tissue from the left kidney (partial nephrectomy, 3.76 grams, 2.2 x 2.0 x 1.9 cm). DIAGNOSIS: Kidney, left, partial nephrectomy: Grade 1 (of 4) renal cell carcinoma,  papillary type, forms a 1.9 x 1.7 x 1.7 cm mass. The tumor is confined to the kidney. Coagulative tumor necrosis is absent. Sarcomatoid differentiation is absent.  The surgical margins are negative for tumor (free by 0.2 cm). AMENDMENTS : Revision Description:. Review of permanent sections reveals the tumor to be a grade 1 (of 4) renal cell carcinoma, papillary type. ..Original Diagnosis... Kidney, left, partial nephrectomy: Grade 1 (of 4) renal cel1 carcinoma, clear cell type, forms a 1.9 x 1.7 x 1.7 cm mass. The. tumor is confined to the kidney.  Coagulative tumor necrosis is absent. Sarcomatoid differentiation is absent. The surgical margins are negative for tumor (free by 0.2 cm).
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diff --git a/output/text/9d2f22c2-7683-4787-9fd8-f72039a66076.txt b/output/text/9d2f22c2-7683-4787-9fd8-f72039a66076.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8d439c2d5c3096ff6b7abedb8e25e3b834a72819
--- /dev/null
+++ b/output/text/9d2f22c2-7683-4787-9fd8-f72039a66076.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Jcs-0-3 Cuuinomn, mfiHraHNg ouctil Nos 85oo/3 8it: brast, Nos C50.9 ya4/n M TOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: FMP/SSN: Specimen #: DOB/Age/Sex: Race: Location: Taken: Physician(s) : Received: Reported: SPECIMEN: A: LEFT BREAST LUMPECTOMY B: AXILLARY CONTENTS C: LEFT SUPRACLAVICULAR LYMPH NODE FINAL DIAGNOSIS: A. LEFT BREAST, LUMPECTOMY: RESIDUAL INFILTRATING DUCTAL CARCINOMA, POORLY DIFFERENTIATED RESIDUAL TUMOR SIZE: 2.5 X 2.0 X 1.5 CM DEEP SURIGIAL MARGIN INVOLVED BY MAIN TUMOR MEDIAL, SUPERIOR, AND INFERIOR MARGINS FOCALLY INVOLVED BY DISCONTINUOUS TUMOR FOCI (LOCAL MICROMETASTASES) EXTENSIVE LYMPHATIC INVOLVEMENT LEFT AXILLARY CONTENTS, DISSECTION: B. METASTATIC CARCINOMA INVOLVING 18 OF 20 EXAMINED LYMPH NODES EXTENSIVE EXTRANODAL EXTENSION AND NON-NODAL METASTASES C. LEFT SUPRACLAVICULAR LYMPH NODE, EXCISON:  METASTATIC CARCINOMA INVOLVING 1 EXAMINED LYMPH NODE COMMENT : The findings were discussed with by phone The deep surgical margin is involved by residual gross tumor (Block A24). The medial, superior, and inferior margins are involved (< 0.6mm) by microscopic foci, separate from the tumor. (Blocks A5, A10, All, A23, A39). Of the 18 involved axillary lymph nodes, 1 has a micrometastasis (B3). An additional lymph node (b22) has isolated tumor cells. These were identified by routine light microscopy and hematoxylin-eosin stain. Report Electronically Sianed Out ** UUID:0E4B0EA9-14D1-4A82-814 Redacted TCGA-A2-A04P-01A-PR Page 1 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 Continued on Next Page
+
+--- Page 2 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974S SURGICAL PATHOLOGY REPORT Patient: Specimen #: CLINICAL DIAGNOSIS AND HISTORY: A year old female with left breast cancer with a positive margin. Palpable lymph node. PRE-OPERATIVE DIAGNOSIS: Left breast cancer. POST-OPERATIVE DIAGNOSIS: Left breast cancer. GROSS DESCRIPTION: A. LEFT BREAsT LUMPECTOMy Received fresh, labeled with the patient's name, and designated "LEFT BREAST TISSUE, SKIN INTERIOR, ONE STITCH MEDIAL, TwO sTITCHES suPERIOR" is a specimen which consists of a piece of fibrofatty tissue, 6.5 x 6.5 x 5.3cm with an overlying ellipse of skin, 5.0 x 2.Ocm. There is a 3.5cm scar on the skin surface. Posteriorly a small patch of skeletal muscle is noted. The specimen is oriented with sutures (one - medial; two - superior). Inked as follows: blue  superior; green - inferior; yellow - medial, red - lateral, and black - posterior. Sectioning reveals a 3.0cm biopsy cavity with hemorrhagic walls and surrounding fat necrosis in the medial half of the specimen. Medially adjacent to the cavity and involving the deep margin is a firm, tan tumor measuring 2.5 x 2.0 x 1.5cm. The remaining tissue is fat and. fibrous tissue. Sections of skin, tumor, and grossly normal fibrous tissue are harvested for the cbcp protocol with matching paraffin sections as follows: A1, skin, lateral tip; A2, tumor, medial portion; A3, tumor, lateral aspect; A4, grossly normal fibrous, mid medial - superior, 2.5cm from the tum; A5-A6, medial margin; A7-A8, adjacent representative section; A9-A12, biopsy cavity; A13-A17, representative biopsy cavity; A18  A19, biopsy cavity; A20-A22, biopsy cavity; A23-A25, biopsy cavity; A26-A28, biopsy cavity; A29-A30, biopsy cavity; A31-A33, adjacent left mid section; A34, representative section; A35, representative section; A36-A39, lateral margin. 39cF B. AxILLARy coNTENTs Received fresh, labeled with the patient's name, anddesignated "AXILLARY CONTENTS, LEFT TAG AT HIGHEST AXILLARY NODE" is a specimen which consists of a piece of soft yellow tissue, 14.5 x 6.5 x 3.5cm, containing numerous and large lymph nodes. There are several cyst-like structures found on serial sectioning ranging in size from 2.5 x 2.0 x 1.0cm to 1.5 x 1.5 x 1.0cm. The cyst are filled with a red viscous fluid. Further sectioning reveals a 3.5 x 3.0 x 2.0cm hemorrhagic cyst-like structure that has a tan-red surface and is poorly defined. Its mass trails to the lateral edge biopsy tail. Multiple possible lymph nodes are identified ranging in size from 2.0 x 2.0 x 1.5cm to 0.4 x 0.3 x 0.2cm. Two grossly positive lymh nodes and one grossly benign lymph node Page 2 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974S
+
+--- Page 3 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974S SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION (continued) : are harvested for the cbcp protocol with matching paraffin sections as follow: Cassette B1, lymph node with tumor, 2.0 x 2.0 x 1.2cm, lower axillary tale; B2, lymph node with tumor, 1.6cm, lower axillary tail; B3, grossly benign lymph node, 0.7cm, upper axillary tail; B4, grossly. positive single lymph node; B5, single lymph node in multiple pieces; B6-B7, multiple possible lymph nodes; B8, bisected possible lymph node;. B9, single positive possible lymph node; B1o, single possible bisected lymph node; B1l, fragments of possible lymph node; B12, fragments of possible lymph node; B13-B14, bisected possible lymph node; B15, possible 1ymph node; B16, single possible lymph node; B17-B18, skeletal muscle with. cyst wall; B19-B22, representative sections of axillary mass; B23-B25, area of possible lymph nodes. 25cF. C. LEFT SUPRACLAVICULAR LYMPH NODE Received in formalin, labeled with the patient's name, and designated "LEFT SUPRACLAVICULAR LYMPH NODE" is a specimen which consists of a 1.3 x 0.7cm lymph node containing a 0.8cm tumor. A portion of the lymph node is submitted for the cacp protocol. 1CF Page 3 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974S End of Report
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diff --git a/output/text/9d40bf32-c1b2-4460-87db-3f769264561d.txt b/output/text/9d40bf32-c1b2-4460-87db-3f769264561d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9f351791026405843379026d5d79d27befcbed43
--- /dev/null
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@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+Surg Path Final Report  Final Report * * Final Report *. icd-O-3 carcinomg,losular, SURG PATH FINAL REPORT i^ FsHg+ing 85ZIJ3 SURGICAL PATHOLOGY sit: begst,nos Collected: C50. 9 Accession: Physician: PROcEDUrE Right breast lumpectomy. SPECIMEN: A. R. breast lump. Nylon suture at posterior margin. Beige suture superior margin. B. Sentinel node #1. C. Sentinel node #2. D. Right breast tissue (black suture most superior margin). E. Right breast tissue (black suture at most anterior margin). HISTORY Right breast cancer. GROSS A. Received fresh in a container labeled *right breast tissue" is a. fragment of fibrofatty breast tissue (5.7 cm in medial-lateral. dimension, 7 cm in superior-inferior dimension, 1.8 cm in anterior-posterior dimension) oriented by attached sutures. An accompanying specimen radiograph reveals abundant radiodense tissue. The density corresponds to a sclerotic. gray-white, hard tumor mass (2.8 cm in greatest dimension) which is within 1-2 mm of the anterior margin, 0.5 cm from the posterior margin, 0.6 cm from the. medial margin, approximately 1.4 cm from the lateral margin and 1.2. cm from the superior margin. The remaining parenchyma consists of abundant firm white fibrous tissue with scattered cysts up to 2-3 mm. in diameter, along with dilated ducts containing opaque yellow-tan, paste-like material.  Total fixation time in formalin is approximately 28 hours. A representative portion of the tumor is submitted for the Ink Code: Black - posterior. Blue - anterior. Green - lateral. Criter Red - medial. Orange - superior. Purple - inferior. J33 Printed by: UUID:14E2FC4E-7205-4929-8185-7FF3006F08AD TCGA-AC-A3QP-01A-PR Redacted Page 1 of 4 Printed on: (Continued)
+
+--- Page 2 ---
+Surg Path Final Report * Final Report *. 1. Superior margin.. 2-3 and 4-5. Full thickness bisected cross sections, including nearest radial margins. 6-7. Indurated parenchyma away from tumor. 8. Inferior margin.  Received in formalin in a container labeled -sentinel node #1~. is a 1.8 cm in greatest dimension, blue-gray, fatty lymph node. C.  Received in formalin in a container labeled *sentinel node #2* is a 0.6 cm, firm, tan and gray lymph node..  Received in formalin in a container labeled *right breast. D. tissue, black suture most superior margin" is a sheet of fibrofatty. tissue (4 x 3 x 1.2 cm) oriented by an attached suture.. Ink Code:. Black - superior margin (adjacent to suture). Blue - opposing margin. The tissue is serially sectioned and submitted in its entirety in three cassettes E. Received in formalin in a container labeled -right breast tissue tissue (2.9 x 1.6 x 0.9 cm) oriented by an attached suture. Ink Code:. Black - anterior margin (adjacent to suture).. Blue - opposing margin. The specimen is serially sectioned and submitted in its entirety in two cassettes. MICROSCOPIC See diagnosis. DIAGNOSIS A. Right breast lump. lumpectomy: Invasive lobular carcinoma (see comment). B. Sentinel lymph node #1, excision:. One lymph node involved by metastatic adenocarcinoma tlargest metastatic focus 2 mm) (1/1). c. Sentinel lymph node #2, excision:. One benign lymph node, free of tumor (o/l).. Right breast tissue, excision: Printed by: Page 2 ot 4 Printed on: (Continued)s
+
+--- Page 3 ---
+Surg Path Final Report * Final Report * Microscopic foci of invasive lobular carcinoma (up to 5 mm in greatest dimension). Tiny focus of lobular cancerization. Neoplasm is approximately 4-5 mm from most superior margin (black inked margin, adjacent to suture) and at blue inked opposing aspect. E.  Right breast tissue, excision:. No tumor is seen. COMMENT BREAST CARCINOMA SUMMARY: SPecIMEN: Partial breast. PROCEDURE: Lumpectomy. SPEcIMEN INrEGRITy: Single intact with additional margin submitted in parts c (superior margin) and D (anterior margin). SPECIMEN LATERALITY: Right breast lumpectomy. SPECIMEN SIZE: 5.7 x 7 x 1.8 cm. TUMOR SIZE:  2.8 cm. TUMOR FocaLITy: A 2.8 cm focus of invasive lobular carcinoma, and additional tiny foci (up to 5 mm) of invasive lobular carcinoma away from tumor. SKIN INVOLVEMENT: Skin not present. NIPPLE INVOLVEMENT: Nipple not present. SKELETAL MUSCLE INVOLVEMENT: Skeletal muscle not present. DUCTAL CARCINOMA IN SITU (DCIS) : Negative. LOBULAR CARCINOMA IN SITU (LCIS) : Present. HIsToLogic Type: Invasive lobular carcinoma. GRADING (NOTrINGHAM) : Tubular formation score: Score 3. NUCLEAR PLEOMORPHISM SCORE: ScOre 2. MITOTIC RATE SCORE: ScOre 1. COMBINED GRADE (NOTTINGHAM): Grade 2 (intermediate grade). LYMPHOVASCULAR INVASION: Not identified. MARGIn OF ExcisioN: Final margins appear free of tumor (closest margin is superior. approximately 4-5 mm. part D). Lymph Nopes: One sentinel lymph node involved by metastatic lobular. carcinoma (sentinel lymph node #l, part B (largest tumor focus is 2 mm) (1/2). MICROCALCIFICATION: Not identified. OTheR FINDINGs: Fibrocystic changes, usual ductal hyperplasia. HORMONE REcEPrORs: Reported (estrogen receptor positive (70t, strong): Progesterone receptor positive (over 9ot, strong). HER-2/NEU: Reported (equivocal (2+) by immunohistochemistry, FISH pending. PATHOLOGIC TNM (AJCC EDITION): T2 N1mic MX. NOTE: A cytokeratin E1/e3 immunohistochemical stain was performed on parts B (sentinel lymph node #1) and C (sentinel lymph node #2). It is strongly positive on part B (sentinel lymph node #1) within the metastatic tumor cells, and supports the diagnosis. It is negative within part c lsentinel lymph node #2). consistent with benign lymph node. Printed by:  Page 3 of 4 Printed on: (Continued)
+
+--- Page 4 ---
+Surg Path Final Report   Finai Report * 'actronic Signature) Completed Action List: * Order by on Type: Surn Path Final Report. Date: Status: Auth (Verified) Title: SURG PATH FINAL REPORT Encounter info:. Printed by: Page 4 ot 4 Printed on: (End of Report)
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diff --git a/output/text/9d471504-140d-4732-9367-60480655d65c.txt b/output/text/9d471504-140d-4732-9367-60480655d65c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8c983897930b0e235784b667cab10d982c210b02
--- /dev/null
+++ b/output/text/9d471504-140d-4732-9367-60480655d65c.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+LGD-o 3 SURGICAL PATHOLOGY REVISED REPORT Case Number : O8s 7d3 N6S Site Syoraglsttto C32 1 Diagnosis: 84 5/2i1 3 A: Nerve, pharyngeal plexus, biopsy - Skeletal muscle, fibroadipose connective tissue and nerve - No malignancy identified B: Lymph nodes, left, level 2, regional node dissection - 2 of 14 lymph nodes positive for metastatic squamous cell carcinoma, 1.8 cm in greatest dimension with extracapsular extension (2/14) C: Lymph nodes, left neck level 3, regional node dissection - 3 of 13 lymph nodes positive for metastatic squamous cell carcinoma, size 2.8 cm in greatest dimension with extracapsular extension (3/13) D: Lymph nodes, left neck, level 4, regional node dissection - 13 lymph nodes negative for metastatic carcinoma (0/13) E: Lymph nodes, right neck level 2, regional node dissection - 2 of 8 lymph nodes positive for metastatic squamous cell carcinoma, size 3.2 cm in greatest dimension without extracapsular extension (2/8) F: Lymph nodes, right neck level 3, regional node dissection - 1 of 15 lymph nodes positive for metastatic squamous cell carcinoma, size 2.4 cm in greatest dimension with no extracapsular extension (1/15) G: Lymph nodes, right neck, level 4, regional node dissection  1 of 24 lymph nodes positive for metastatic squamous cell carcinoma, 3 mm in greatest dimension with no extracapsular extension (1/24) - Thyroid epithelium also present within subcapsular sinus of 2 lymph nodes, cannot exclude metastatic thyroid carcinoma (see comment) H: Larynx, laryngectomy Tumor histologic type/subtype: invasive squamous cell carcinoma Histologic grade: moderately differentiated Location of primary site: Bilateral supraglottis, involving
+
+--- Page 2 ---
+bilateral false cords and bilateral aryepiglottic folds, extending focally into left glottis, anteriorly into epiglottis involving epiglottic cartilage, and anteriorly into hyoid bone. Invasive carcinoma abuts but does not involve bilateral strap muscles. The vallecula is negative. Size: 3.9 x 3.8 x 1.6 cm per gross measurement Extent of invasion: Angiolymphatic: not identified; however, multiple lymph nodes are positive in subsequently submitted sections Adjacent subsite: not applicable Vocal cord fixation: not identified Into/through cartilage: invasive carcinoma invades epiglottic cartilage but not thyroid cartilage Outside the larynx: tumor involves hyoid bone P16 IHc status: pending (H3) HR Hpv ISH status: pending (H3) In situ carcinoma: present Surgical Margins: Negative but very close (<l mm) from blue inked right margin. Black inked left margin is 2 mm from the invasive carcinoma and anterior is 6 mm from invasive carcinoma. Inferior tracheal margin is negative. Mucosal margins are negative for squamous cell carcinoma in situ. Lymph nodes: see additional sections Other significant findings: - Perineural invasion present AJCC PATHOLOGIC TNM STAGE: pT4a pN2c pMx NotE: This pathologic stage assessment is based on information available at the time of this report, and is subject to change pending clinical review and additional information. Comment: In specimen G, bland appearing thyroid epithelium is present in the subcapsular sinus of two lymph nodes. No parenchymal involvement is identified, and no nuclear features of papillary thyroid carcinoma are identified. This may represent benign
+
+--- Page 3 ---
+thyroid inclusions in lymph node; however, a metastatic carcinoma of thyroid origin cannot be excluded. Clinical evaluation and imaging of the thyroid gland is recommended. Clinical History: -year-old female with larynx cancer.. Gross Description: Received are eight appropriately labeled containers. Container A is additionally labeled "pharyngeal plexus nerve" and is an 8 x 6 x 2 mm aggregate of two red/tan soft tissue fragments, Al, Container B is additionally labeled "left neck level 2" and consists of a 3.2 x 2.5 x 1.0 cm fragment of yellow/tan fibrofatty tissue with embedded sutures. Seven lymph node candidates up to 2.1 cm in greatest dimension are identified. Block Summary: B1 - Three lymph node candidates. B2 - Two lymph node candidates. B3 - One lymph node candidate, trisected B4. - One lymph node candidate, trisected. B5-B6 - Remainder of fat, Container c is additionally labeled "left neck level 3" and is a 5.4 x 3.5 x 1.5 cm aggregate of yellow/tan fibrofatty tissue dissected for lymph node candidates. Multiple lymph node candidates up to 2.8 cm in greatest dimension are identified. Block Summary: c1 - Four lymph node candidates c2 - Four lymph node candidates c3 - Two lymph node candidates c4 - One lymph node candidate, sectioned C5 - One lymph node candidate, trisected C6 - Representative of one grossly positive lymph node candidate (largest) Tissue remains in formalin. Container D is additionally labeled "left level 4 neck dissection" and is a 4.4 x 2.5 x 1.2 cm fragment of cauterized fibrofatty tissue dissected for lymph node candidates. Multiple lymph node candidates up to 1.2 cm in greatest dimension are identified.
+
+--- Page 4 ---
+Block Summary: D1 - Seven lymph node candidates D2 - Two lymph node candidates D3 - Representative section from large caliber vessel Tissue remains in formalin. Container E is additionally labeled "right level 2 neck dissection" and is a 4.5 x 2.8 x 1.6 cm fragment of cauterized fibrofatty tissue dissected for lymph node candidates. Four lymph node candidates up to 3.2 cm in greatest dimension are identified. Block Summary: E1 - Two lymph node candidates E2 - One lymph node candidate, bisected. E3 - Representative section from largest lymph node (grossly positive) Tissue remains in formalin. Container F is additionally labeled "right level 3 neck dissection" and is a 5.4 x 3.7 x 1.5 cm aggregate of cauterized fibrofatty tissue and muscle. Multiple lymph node candidates up to 2.4 cm in greatest dimension are identified. Block Summary: F1 - Four lymph node candidates F2 - Three lymph node candidates. F3 - One lymph node candidate, sectioned F4 - One lymph node candidate, bisected. F5 - One lymph node candidate, bisected F6 - Representative section of skeletal muscle F7 - Representative section of largest, grossly positive lymph node candidate Tissue remains in formalin. Container G is additionally labeled "right level 4 neck dissection" and is a 4.5 x 1.9 x 1.4 cm aggregate of fibrofatty tissue, dissected for lymph node candidates. Lymph nodes up to 0.8 cm in greatest dimension are identified. Block Summary: G1 - Five lymph node candidates. G2 - Five lymph node candidates G3 - Five lymph node candidates G4 - Three lymph node candidates. Tissue remains in formalin. Specimen H:.
+
+--- Page 5 ---
+Specimen fixation: Formalin. Type of specimen: Total laryngectomy with attached anterior strap muscles.. Size of specimen: 8.1 cm superior to inferior, 5.2 cm right to left, 3.2 cm anterior to posterior.. Orienta.ion of specimen: Right/blue, left/black,. vollecula/yellow and anterior/midline green. Tumor description: Well demarcated, centrally ulcerated with peripherally raised firm white borders.. Location of tumor: Supraglottis involving the bilateral false cords and extending across the midline to the right and left aryepiglottic fold.. Tumor size: 3.9 cm superior to inferior x 3.8 cm right to left x 1.6 cm in thickness.. Extent of tumor: The tumor involves both right and left false cords and the anterior commissure. It extends to the right and left aryepiglottic folds and creeps up onto the epiglottis. The vallecula is grossly unremarkable. The hyoid bone is present and unremarkable. The horns of the thyroid cartilage are present and grossly unremarkable. The true cords in the subglottic region are unremarkable. The pyriform sinuses are unremarkable with the excepticn of undermining tumor. Sectioning through the tumor reveals a solid white cut surface with extension into the soft tissues of the epiglottis extending antericrly towards the vallecula (0.3 cm from the vallecula margin (H4), extension to the underlying thyroid cartilage but does nc: appear to invade the thyroid cartilage, the anterior neck mussles are freely movable over the tumor, bilaterally. The tumor u:ndermines the mucosa of the right and left aryepiglottic folds. The subglottic region is grossly unremarkable. The hyoid bone is intact and the tumor is freely movable over the hyoid bone. Distance of tumor from surgical margins: The mucosa component of the tumor comes within 0.9 cm of the right pyriform sinus margin, 1.2 cm from the left pyriform sinus margin, 2.1 cm from the antarior vallecular margin, 3.3 cm from the inferior trachea. ring margin, 0.2 cm from the blue inked right anterior
+
+--- Page 6 ---
+soft tissue margin, 0.3 cm from the black inked left anterior soft tissue margin, and 0.4 cm from the green inked anterior midline margin. Description of remainder of tissue: The subglottis is lined by grossly unremarkable mucosa. The anterior strap muscles are unremarkable. No thyroid gland is identified. Tissue submitted for special investigations: Tumor is given to tissue procurement.. Lymph nodes: Submitted separately. Digital photograph taken: Yes Block Summary: Inking: right/blue, left/black, vallecula/yellow and anterior midline/green H1 - En face tracheal margin H2 - Perpendicular sections of right aryepiglottic fold into pyriform sinus H3 - Perpendicular sections of left aryepiglottic fold into pyriform sinus H4 - Epiglottis and vallecula H5 - Right glottis. H6 - Left glottis (contains thyroid cartilage) H7 - Anterior commissure. H8 - Perpendicular sections of green inked anterior midline, black inked left, blue inked right strap muscle margin. H9 - Remainder of right superior mucosal margin, en face H10 - Remainder of left superior mucosal margin, en face Hll - Perpendicular section of anterior midline hyoid bone beneath tumor (not grossly involved) (decal) Addendum For immunohistochemistry.. Addendum Comment. P16 is positive and Hpv high risk is negative by Ish in a. representative section of invasive carcinoma (H3). TTF-1 and thyroglobulin are attempted on G3 to highlight the foci of thyroid glands within lymph nodes; however, both foci. are cut through and immunohistochemistry is not contributory. The previous diagnoses are unchanged.
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diff --git a/output/text/9da5d5f8-0dd7-46fa-bb37-141e143627b7.txt b/output/text/9da5d5f8-0dd7-46fa-bb37-141e143627b7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f95709e1b98388eb8a803ebdf5d3c1cd0072a31b
--- /dev/null
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@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+5/23/n Jcs-0-3 Sit: buast, nos C5o.9. 5723/ (A) SENTINEL LYMPH NODE #1, LEFT AXiLLA, BIOPSY: One lymph node, no tumor present (0/1). Cytokeratin stain shows no evidence ot metastatic carcinoma.. (B) SENTINEL LYMPH NODE #2, LEFT AXILLA, BIOPSY: One lymph node, no tumor present (0/1). Cytokeratin stain shows no evidence of metastatic carcinoma. (C) SENTiNEL LYMPH NODE #3, LEFT AXILLA, BIOPSY: One lymph node, no tumor present (0/1). Cytokeratin stain shows no evidence of metastatic carcinoma.. (DY LEFT BREAST, SEGMENTAL MASTECTOMY: INVASIVE DUCTAL CARCINOMA OF BREAST, MODIFIED BLACK'S NUCLEAR GRADE 3(POORLY DIFFERENTIATED) (SEE COMMENT). INVASIVE CARCINOMA MEASURES 3.0 CM IN GREATEST DIMENSION GROSSLY.  No definitive lymphatic/vascular invasion identified. FOCAL INTRADUCTAL CARCINOMA (DCIS), MODIFIED BLACK'S NUCLEAR GRADE 3 (HIGH GRADE),  SOLID AND CRIBRIFORM TYPES WITH NECROSIS, COMPRISING APPROXIMATELY 10% OF TUMOR. INVASIVE AND IN SITU CARCINOMA ARE O.5 CM TO THE CLOSEST ANTERIOR MARGIN. Remaining surgical margins are widely free of tumor. (E) SENTINEL LYMPH NODE #4, LEfT AXILLA, BIOPSY: Benign tibroadipose tissue, no lymph node or tumor present.. Entire report and diagnosis completed by. COMMENT Immunohistochemical staining is performed on a representative formalin-fixed, paraffin- embedded section of INVASIVE CARCiNOMA, left breast, block D6. MARKER RESULTS % POSITIVE SCORE Estrogen Receptor Negative 0% N/A Progesterone Receptor  Negative 0%  N/A HER-2/neu overexpression Negative 1+ UUID:5A315635-886B-459E-AF5D-079F66E859F0 TCGA-GM-A2DB-01A-PR Redacted
+
+--- Page 2 ---
+Due to the above HER-2/neu immunohistochemical staining result, gene copy level (HER-2/neu: CEP17 signal ratio) will be evaluated by FISH and a separate report will be issued. FOOTNOTE Estrogen receptor was assessed by immunohistochemistry using antibody 6F11 (* Progesterone receptor was assessed by immunohistochemistry using antibody PgR1294( HER-2/neu was assessed by immunohistochemistry using antibody AB8 t GROSS DESCRIPTION (A) SENTINEL LYMPH NODE #1, LEFT AXILLA, IN VIVO 69, EX VIVO 55, BLUE - Two fragments of tissue including one Ivmph node measures 2.0 x 1.5 x 0.8 cm. Serially sectioned Touch preparation performed. SECTION CODE: A1, A2, one lymoh node; A3, A4, second fragment of tissue. *TP/DX: NO TUMOR PRESENT. (B) SENTINEL LYMPH NODE #2, LEFT AXILLA, BLUE, IN VIVO 21, EX VIVO 39 - A single lymph node (2.5 x 1.8 x 1.0 cm). Serially sectioned. Touch preparation performed. Entirely submitted. SECTION CODE: B1-B3, one lymph node serially sectioned. *TP/DX: NO TUMOR PRESENT. (C) SENTINEL LYMPH NODE #3, LEFT AXILLA, BLUE, IN VIVO 15, EX VIVO 5 - A sing|e Iymph node (1.0 x 0.8 x 0.5 cm). Serially sectioned. Touch preparation performed. SECTION CODE: C, one lymph node serially sectioned. *TP/DX: NO TUMOR PRESENT. (D) LEFT BREAST, SEGMENTAL MASTECTOMY, SHORT STITCH SUPERIOR, LONG STITCH LATERAL - The specimen consists of an oriented segmental mastectomy measuring 9.0 x 6.0 x 3.5 cm. Serially sectioned to reveal a 3.0 cm mass, which is 0.5 cm to the closest anterior margin. Remaining surgical margins are widely free of tumor. The specimen is x-rayed, and a surgical clip is identified within the tumor (slice #4). Suspicious areas are circled by the radiologist for sampling. INK CODE: Superior - blue, anterior - yellow, inferior - green, medial and lateral - red, deep - black.. SECTION CODE: D1, perpendicular sections of medial margin; D2-D5, circled by radiologist in slice #3 with anterior margin; D6, D7, tumor/clipped area in slice #4 (mirror images); D8, anterior margin, slice #4; D9, inferior margin, slice #4; D10, deep margin, slice #4; D11, superior margin, slice #4; D12, D13, remaining tumor area in slice #4; D14-D16, circled by the radiologist in slice #5; D17, inferior and deep margin, slice #5; D18, remaining tumor area in slice #5; D19, D20, circled by radiologist in slice #6; D21, D22, circled by radiologist in slice #7; D23, perpendicular sections of lateral margin.. (E) SENTINEL LYMPH NODE #4, BLUE, LEFT AXILLA IN VIVO 20, EX VIVO 20 - An irregular fragment of tibroadipose tissue (3.0 x 2.0 x 0.6 cm). Serially sectioned and no lymph nodes grossly identified. The specimen is entirely submitted in E1-E3.. CLINICAL HISTORY Newly diagnosed left breast cancer.
+
+--- Page 3 ---
+SNOMED CODES T-04050, M-85003, M-85002, T-C4714, M-00110 "Some tests reported here may have been developed and performance characteristics determined by These tests have not been specifically cleared or approved by the U.S. Food and Drug Administration." Released by: Start of ADDENDUM ADDENDUM Addendum completed by ! SPECIMEN SOURCE Left breast SUMMARY Tissue section ot the invasive carcinoma 1 D6 was evaluated for HER-2/neu gene amplification by interphase fluorescence in situ hybridization technique using the PathVysion HER-2/neu DNA Probe Kit (LSI HER-2/neu /CEP17 Slide adequacy is satistactory. Sixty tumor nuclei were counted and showed an average of 1.67 copies of LSI HER-2/neu gene per nucleus and an average of 1.50 copies of CEP17 per nucleus. Negative and positive controls (established by ) with this batch are appropriate. Two representative images have been archived. INTERPRETATION The tumor cells demonstrated no amplitication of the HER-2/neu gene copy levels (HER-2/neu: CEP17 signal ratio: 1.11) The following guideline has been established for HER-2/neu testing: Normal HER-2/neu levels: <1.80; Equivocal HER-2/neu leveis: 1.80 -- 2.20; Amplified HER-2/neu levels: >2.20 (Ref: Arch Pathol Lab Med. 2007; 131:18-43) NOTES
+
+--- Page 4 ---
+The LSI HER-2/neu probe is specific for the HER-2/neu gene Locus (17q 11.2-q12) and the CEP 17 DNA probe is specitic tor the alpha satellite DNA sequence at the centromeric region of. Chromosome 17 (17 p11.1 -q11.2). This test has been cleared and approved for specitic uses by the U.S. Food and Drug. Administration. Its system is operating within the performance specifications stated in the product  insert. Released by: --END OF REPORT--
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diff --git a/output/text/9db8268c-46a9-4d0b-89bc-a4b18e81996d.txt b/output/text/9db8268c-46a9-4d0b-89bc-a4b18e81996d.txt
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index 0000000000000000000000000000000000000000..58dacc82e6df9c63565a5431eb4152bf98069b8a
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+
+--- Page 1 ---
+TCGA-B8-4146 SURGICAL PATHOLOGY Surgical Pathology Report Accession #: Diagnosis: Kidney, right, nephrectomy. Tumor histologic type/subtype: Renal cell carcinoma, clear. cell subtype Histologic grade (if applicable): Fuhrman grade 2 (of 4) Tumor size (greatest dimension): 4.5 cm. Extent of tumor invasion: Extra-capsular invasion: not identified. Renal vein: not involved Ureter: not involved Venous (large vessel) not involved. Lymphatic (small vessel): not involved. Surgical margins: Perirenal adipose tissue: not involved. Renal vein: not involved. Renal artery: not involved. Ureter: not involved. Adrenal gland: not submitted Lymph nodes: none submitted Other significant findings: none AJCC Stage: pT1b pNx pMx This staging information is based on information available
+
+--- Page 2 ---
+at the time of this report, and is subject to change pending clinical review and additional information. Clinical History:. with a renal mass.. Gross Description: Specimen fixation: formalin Type of specimen: nephrectomy, NOs. Side of specimen: right Size and weight of specimen: 281.4 grams, 14.5 x 8.0 x 5.0 cm overall dimensions composed of a 13.3 x 6 x 3.5 cm kidney with a small amount of attached perinephric fat and a 3 cm length of ureter. No adrenal gland is identified. Orientation: The external surface is marked with blue ink. Presence/absence of adrenal gland: absent Tumor description/site: The tumor is located in the superior/medial pole of the kidney and is a solitary circumscribed, orange/red soft nodule. Tumor size: 4.5 x 4.4 x 4.2 cm Presence/absence of multicentricity: absent Confinement/non-confinement to the kidney: appears confined to the kidney. Extent of invasion: Perirenal adipose tissue: tumor grossly does not involve Gerota' s fascia: tumor grossly does not involve Renal vein: tumor grossly does not involve Ureter: tumor grossly does not involve. Other organs: tumor grossly does not involve. Surgical margins:. Perirenal adipose tissue: grossly negative. Renal vein: grossly negative
+
+--- Page 3 ---
+Renal artery: grossly negative. Ureter: grossly negative. Description of kidney away from tumor: Dark red/brown, homogeneous with an average cortical thickness of 0.6 cm.. The pelvic urothelium is velvety, red/tan and of normal. caliber. The ureter is patent.. Lymph nodes (hilar): No hilar lymph nodes are identified,. but representative from the hilar fat is submitted for evaluation. Other significant findings: none. Tissue submitted for special investigations: Tumor and normal are given to Tissue Procurement Digital photograph taken: no Block summary: A1 - ureter and vascular margins of resection, en face A2 - tumor expanding renal capsule A3 - tumor in relationship to posterior perinephric fat A4 - tumor in relationship to blue inked capsular margin, posterior A5 - tumor and normal renal parenchyma. A6 - normal kidney away from tumor. A7-A8 - representative sections from hilar adipose
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diff --git a/output/text/9dd6e151-2cf4-4189-902a-5197c5d20e41.txt b/output/text/9dd6e151-2cf4-4189-902a-5197c5d20e41.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6534fb3410e7dc01856d977a35cdda2471a9a7d9
--- /dev/null
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+
+--- Page 1 ---
+Surgical Pathology TCGA-DZ-6133 TISSUE DESCRIPTION: C2 Right kidney (4.6 x 3.8 x 3.2 cm), tissue from right chest. (5.0 x 3.2 x 1.5 cm with skin ellipse--4.0 x 1.1 cm), and new superior right chest margin (3.9 x 2.0 x 1.1 cm) DIAGNOSIS: Kidney, right, partial nephrectomy:  Grade 2 (of 4) renal cell carcinoma, papillary type, forms a 3.1 x 3.0 x 2.8 cm mass.? The tumor is confined to the kidney. Coagulative tumor. necrosis is not. present. Sarcomatoid differentiation is absent. The surgical margins are negative.. Skin right chest, excisional biopsy: Infiltrating grade 3 (of 4) carcinoma consistent with breast primary is identified within a previous biopsy site and scar tissue over an area. measuring 1.0 cm in greatest dimension. The tumor involves the dermis and subcutaneous tissue. Margins of excision following re- excision of the superior margin are negative for tumor.
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diff --git a/output/text/9ddbf5f1-19dc-49eb-a15f-7c3999e65029.txt b/output/text/9ddbf5f1-19dc-49eb-a15f-7c3999e65029.txt
new file mode 100644
index 0000000000000000000000000000000000000000..19dd31cba9ce18c0da90773cd836d1cee863830a
--- /dev/null
+++ b/output/text/9ddbf5f1-19dc-49eb-a15f-7c3999e65029.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+UUID:43D912CD-BD3C-4E69-B28B-AB2E173C0BC2 TCGA-A7-A0DC-01A-PR Redacted 1cs-0-3 Carcnoma, duc+sl iN-sifu,No5 85oof2 SPECIMEN A. Left sentinel lymph node #1 Left breast stitch 12 o'clock. C. Left breast, Tail of Spence D. Left breast, Nodule inferior skin flap - stitch 6 o'clock E. Right breast double long 12 o'clock single long hard mass 10 o'clock F.  Palpable area right axilla G. Sentinel node #2, right breast. REPORT REVISED ON AT CLINICAL NOTES PRE-op DiAgnosIs: Bilateral breast carcinoma.. FROZEN SECTION DIAGNOSIS A) Lymph node, sentinel node left, excision: One lymph node negative for metastatic carcinoma (0/1).. FFsl, FFs2: Palpable area, right axilla, biopsy - Benign lymph node present. GFs: Sentinel node #2, right axilla, biopsy - One lymph node with. no evidence of metastasis. GROSS DESCRIPTION A. Received fresh for frozen section labeled "left. sentinel lymph node #1" is an irregularly shaped fragment of blue stained tissue that measures 1.3 x 0.6 x 0.4 cm. in dimension. Tissue is entirely frozen. B. Received fresh, labeled "left breast stitch 12 o'clock" is a 26.0 cm. (medial to lateral) x 24.5 cm.(superior to. inferior) x 4.5 cm.(anterior to posterior) diffusely cauterized and focally blue stained soft, lobulated tan gold-white portion of fibroadipose tissue in keeping with breast designated as left per requisition slip and container and oriented by a single suture as. stated previously. A 5.5 cm. (medial to lateral) x 2.3 cm.(superior GROSS DESCRIPTION to inferior) portion of dusky tan white skin with a central, everted, 1.3 x 1.3 x 0.5 cm. nipple is present along the anterior aspect. The deep margin is inked black and the specimen is. sectioned. There is a roughly spherical, 2.4 cm. clot-filled. biopsy cavity within the lower inner quadrant. The cavity is present within 1.2 cm. of the anterior surface (inked blue see block 2) and 2.8 cm. of the inked deep margin (see block 1). Several cylindrical tan white firm structures are evident within the cavity. The periphery of the cavity is fibrotic with diffuse chalky yellow fat. necrosis. Lateral to the cavity is an ill-defined focus of firm, tan white fibrous tissue with dilated ductal structures (see blocks 6 and 7). Within the center of the focus, there appears to be a
+
+--- Page 2 ---
+stellate 1.0 x 1.0 x 1.0 cm. rubbery tan white lesion which is 0.5 cm. from the inked deep margin (see blocks 7 and 8). The remaining cut surfaces throughout the specimen consists predominately of glistening lobulated golden yellow adipose tissue with a moderate amount of interspersed focally blue stained dense tan white fibrous tissue. No additional mass lesions are identified. Representative sections are submitted in fourteen blocks as labeled. Rs-14. BLOck suMMARy: 1 - Biopsy cavity to inked deep margin; 2 - biopsy cavity to anterior surface; 3-5 - biopsy cavity to adjacent parenchyma; 6 - firm area lateral to biopsy cavity; 7-8 - apparent lesion lateral to biopsy cavity to inked deep margin; 9 - random upper outer quadrant; 10 - upper inner quadrant; 11 - lower inner quadrant; 12 - lower outer quadrant; 13 - junction of the four quadrant; 14 - nipple. C. Received fresh, labeled "tail of Spence", is a 5 x 4 x 1.6 cm. portion of soft, lobulated golden-yellow adipose tissue.  Three soft tan-pink-gold tissues, in keeping with lymph. nodes, measuring up to 1.5 cm. in greatest dimension, are The lymphoid tissues are entirely submitted in three blocks, as GROSS DESCRIPTION labeled.RS-3 BLOcK suMMARy: 1 - One whole presumptive node; 2,3 - one bisected presumptive node per cassette. D. Received fresh, labeled "nodule inferior skin flap -. stitch 6 o'clock", is a 3.8 cm. (9 to 3 o'clock) x 0.9 cm. (12 to 6 o'clock) wrinkled tan-white skin ellipse, with a suture along one aspect, as stated previously. The 12 o'clock half is inked blue and the 6 o'clock half is inked black. There is a stellate, rubbery, 0.6 x 0.6 x 0.6 cm. tan-white nodular lesion within the 9 o'clock half of the specimen, which appears to extend to within less than 0.1 cm. of the inked 12 o'clock surface. The specimen is entirely submitted in a sequential manner from 3 to 9 o'clock in four blocks (nodule block 3). E. Received fresh, labeled "right breast double long 12. o'clock, single long hard mass 10 o'clock" is 27.0. cm.(medial to lateral) x 23.5 cm.(superior to inferior) x 4.5 cm.(anterior to posterior) diffusely cauterized and focally blue stained soft, lobulated tan gold-white portion of fibroadipose tissue in keeping with breast designated as right per requisition slip and container and oriented by double suture as stated previously. A 4.4 cm.(medial to lateral) x 2.5 cm.(superior to inferior) dusky tan white skin ellipse with a central, everted, 1.0 x 1.0 x 0.6 cm. nipple is present along the anterior aspect. A second single suture is present at approximately 9-10 o'clock. The
+
+--- Page 3 ---
+intact deep margin is inked black and the specimen is sectioned. There is a moderately well circumscribed, 5.0 cm.(superior to inferior) x 3.4 cm.(medial to lateral) x 3.0 cm.(anterior to posterior) multi-loculated slightly firm cystic structure subjacent to the aforementioned single suture at the junction of the upper and lower outer quadrants. The cyst focally extends to within 0.3 cm. of the inked deep margin (see blocks 1 and 2) and is 1.5 cm. from GROSS DESCRIPTION the anterior surface (subsequently inked blue). A portion of the cystic focus and a portion of normal parenchyma are submitted for tissue procurement as requested. The cut surfaces throughout the remainder of the specimen consists predominately of glistening lobulated golden yellow adipose tissue with a moderate amount of interspersed diffusely cystic tan white fibrous tissue. No mass lesion or additional abnormalities are identified. Representative sections are submitted in 16 blocks as labeled. Rs-16. BLOck suMMARy: 1-2 - Cystic structure to inked deep margin; 3-4 - cystic structure to inked anterior margin; 5-10 - representative cystic structure to surrounding parenchyma including firm area sequentially from lateral to medial; 11 - random upper outer quadrant; 12 - upper inner quadrant; 13 - lower inner quadrant; 14 lower outer quadrant; 15 - junction of the four quadrants; 16 nipple. F. Container F is labeled with the patient's name, medical record number and "palpable area right axilla". The specimen consists of a single fragment of fatty tissue measuring 2 1.5 x 1 cm.  AS-l. Blocks Fs1 and Fs2. G. Container G is labeled "sentinel node #2 right axilla". The specimen consists of single lymph node measuring 0.8 x 0.5 x 0.5 cm. AsF, GFF, bisected. This case is being handled by Dr.. MICROSCOPIC DESCRIPTION B. Left Breast Invasive carcinoma: Histologic type: Ductal Histologic grade: II MICROSCOPIC DESCRIPTION Overall grade: 6/9
+
+--- Page 4 ---
+Architectural score: 2 Nuclear score: Mitotic score: 2 Greatest dimension (pT): No less than 1.5 cm (adjacent to biopsy cavity) Specimen margins: Negative Vessel invasion: No definitive invasion identified Calcification: Present Nipple (Paget's): Negative Invasion of skin or chest wall:  Negative Ductal carcinoma in situ: Histologic pattern: Cribriform and solid Nuclear grade: 3 Central necrosis: Present % Dcis of total tumor (if mixed): 20% Specimen margins: Dcis is 3 mm from deep margin (two small foci) Calcification: J Present Description of non-tumorous breast: Small papillomas; fibrocystic changes with microcalcifications.. Comments: Previous core biopsy. reviewed. Carcinoma is lateral to prior biopsy site.. Prognostic markers: See core biopsy report, D. "Left breast, Nodule inferior skin flap". Invasive Carcinoma: Histologic type: Ductal Histologic grade: II Overall grade: 6/9 Architectural score: 2 MICROSCOPIC DESCRIPTION Nuclear score: 3 Mitotic score: 1 Greatest dimension (pT): 7 mm Specimen margins: 1.5 mm from resection margin (several areas). Vessel invasion: Negative Calcification: Present Comments: Skin not directly involved by carcinoma.. Focal duct present containing necrotic debris and calcification, without definitive ductal carcinoma in-situ identified. Breast Prognostic Marker Report (Part D). Results Estrogen receptor:......80% Progesterone receptor:..0%.
+
+--- Page 5 ---
+Her2/neu by IhC:.. .0-1+ Interpretation Estrogen receptor:......Positive. Progesterone receptor:..Negative Her2/neu by Ihc:........Negative. Part E.  Right breast. Ductal carcinoma in situ: Outer breast Histologic pattern: Solid, papillary and micropapillary Nuclear grade: 2 Central necrosis:  Absent Tumor size (if pure in situ): 5 cm. Specimen margins: Dcis is focally 2 mm from deep margin and 3. mm from anterior margin. MICROSCOPIC DESCRIPTION Calcification: Present Comments: Fibrocystic changes are intermixed within this complex mass lesion, the majority of which is composed of ducts involved. by carcinoma in-situ. Invasive carcinoma is not identified (p63 performed to evaluate). Portions of case also reviewed by Dr. Nipple: large ducts of nipple involved by ductal carcinoma in-situ. Breast Prognostic Marker Report (Part E) Results Estrogen receptor:......100% Progesterone receptor:..0% Interpretation Estrogen receptor: .Positive Progesterone receptor:..Negative Prognostic markers were done by immunohistochemical stain on paraffin sections from 10% neutral buffered formalin fixed tissue using antibodies on a Benchmark automated stainer. The Her2/neu antibody is clone 4B5 and has been approved by the FDA as an aid in the assessment of breast cancer patients for whom
+
+--- Page 6 ---
+Herceptin treatment is considered. This laboratory meets the test validation and quality assurance requirements of the Asco/cAp guidelines for Her2 testing for. carcinoma of the breast (Arch Pathol Lab Med 2007;131:18-43). MICROSCOPIC DESCRIPTION [A few of the antibodies used in our laboratory may be classified as analyte specific reagents. These antibodies are monitored and controlled in our laboratory and their performance for in vitro diagnosis is well described in the medical literature. They have not been cleared or approved by the FDa.] 4x6, 3, 14x3, 15, 20x2, 25x5 REPORT REVISED ON AT DIAGNOSIS A. Left breast, sentinel lymph node #1, biopsy: One negative lymph node (0/l). B. Breast, left, mastectomy:. Invasive ductal carcinoma, grade II, size no less than 1.5 cm., with associated ductal carcinoma in-situ, grade 3, with necrosis. C. Lymph node, Tail of Spence, left breast, regional resection: Three negative lymph nodes (0/3). D. Breast, left, inferior skin flap nodule, excisional biopsy: Invasive ductal carcinoma, grade II, 7 mm., close to excisional margin. E. Breast, right, mastectomy:. Ductal carcinoma in-situ,grade 2, involving 5 cm area and large ducts of nipple. No invasive carcinoma identified. F. Lymph node, right axilla, biopsy: One negative lymph node (0/1). G. Sentinel lymph node #2, right axilla, biopsy: One negative lymph node (0/1). REPORT REVISED ON AT DIAGNOSIS MD (Electronic Signature) REVISED REPORT Clarification of specimen identification HIPAA
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diff --git a/output/text/9dfbca21-a1b2-474e-8357-17d7fc76b07d.txt b/output/text/9dfbca21-a1b2-474e-8357-17d7fc76b07d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ba8b4dab6bf5989a2001005501fbaaab09bd89a7
--- /dev/null
+++ b/output/text/9dfbca21-a1b2-474e-8357-17d7fc76b07d.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+PREVIOUS DIAGNOSIS INQUIRY PAGE #: UUID:4E5C6CF0-F346-4ECE-B296-0D2DB45138040 SEX: F TCGA-OR-A5K0-01A-PR PAT TYPE: ADM DATE: Redacted  OpER DATE: PROCEDURE: SPHS Patient was hospitalized in tor a hypertensive episode as well as. hypokalemia. A cT showed a left adrenal mass measuring 6.2 x 4.0 cm. She states she is currently easily fatigued. Clinical Diagnosis: Left adrenal mass. Operative Procedure/Tissue Submitted: Left open adrenalectomy. PROCEDURE: SPGD 1. "Left adrenal gland." Received in formalin in a mediun container is a 105 gram, excisional specimen of a nodular gray-tan adrenal gland with a thin rim of surrounding periadrenal fat, measuring 9 x 6.8 x 4.3 cm. The specimen has been previously inked blue and sectioned for tissue procurement. No orientation is given. The remainder of specimen is inked blue, specimen is serially sectioned to reveal a diffusely pink-gray, soft, nodular mass, with smooth cut surface, arising from within a yellow/partially cystic adrenal, with rajority of lesion outside, and a residual of normat yellow adrenal, 3.0 cm on one edge of mass. Ihe periadrenal tat appears to be not involved. The lesion is, otherwise, well-circumscribed with a thin, clear membrane overlying. The specimen is submitted as follows: 1A. Normal adrenal to tumor.. 1B. Cystically dilated area of adrenal, involved with lesion. 1c. Representative section of the mass. 1D. Additional sections of mass. 1E. Additional cystically dilated adrenal. 1F. Additional tumor to adrenal and periadrenal adipose tissue. 1ADDA-1AdDg. Additional sections of tumor to capsule. (nnte. 1E-1G. Thin membrane of capsule slips and might not be represented). PROCEDURE: SPMI ADRENOCORTICAL CARCINOMA Tumor Size: 9 x 6.3 x 4.3 cm. Tumor Weight: 105 grams. Capsular Invasion: Present focally.. Vascular Invasion: Negative. Surgical Margins: Close. IeD-o-3 Carcinomc,adreual sortico) 837D|3 Site; AdreuaI G1aud,Ct tex C74. OLe i|e6|13
+
+--- Page 2 ---
+PREVIOUS DIAGNOSIS INQUIRY REPORT DATE: PAGE #: SEX:F BIRTHDATE: PAT TYPE: ADM DATE: OPER DATE: Necrosis: Present. Mitotic Rate: 8 / 50. Grade: Low. Lynph node status: N.A.. Extra-adrenal Extension: Negative. Stage: pT2NxMx Number of fields reviewed: 25. Mitotic figures: 4. PROCEDURE: SPDXE 1. Lett adrenal gland, resection: Adrenocortical carcinoma. Capsule invasion is present focally, with margins close. :he signing staff pathologist, have personally examined and interpreted the slides from this case. ** END OF PREVIOUS DIAGNOSIS INQUIRY **
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diff --git a/output/text/9e204191-2bfb-4acf-921b-6039fa590323.txt b/output/text/9e204191-2bfb-4acf-921b-6039fa590323.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6927e8c1d21d3c43f6e9a82909fac6ddd97554c9
--- /dev/null
+++ b/output/text/9e204191-2bfb-4acf-921b-6039fa590323.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:0D65923F-583D-42C2-8CA3-0A209D5F0490 TCGA-NH-A8F8-01A-PR Redacted RUN DATE: PAGE 1 RUN TIME: RUN USER: PATIENT: ACCT # LOC AGE/SX: M ROOM REG DR: DOB: BED: STATUS : SPEC #: RECD: STATUS : PERFORMEI COLL : TIME IN FORMALIN: hrs. COLD ISCHEMA TIME: mins. CLINICAL INFORMATION: Pre-Op Diagnosis: Colon CA: R/O metastatic liver involvement. Remarks: Specimen(s) : A. Wedge biopsy liver B. Right hemicolectomy C. Wedge biopsy liver #2 MICROSCOPIC DIAGNOSIS WEDGE BIOPSY LIVER #1:  METASTATIC COLONIC ADENOCARCINOMA PRESENT ON PERMANENT SECTION BUT NOT SEEN ON FROZEN SECTION B. PORTION RIGHT COLON. PORTION TERMINAL ILEUM AND APPENDIX. RIGHT HEMICOLECTOMY: ADENOCARCINOMA OF ASCENDING COLON. LOW GRADE TUMOR MEASURES 5 CM AND PENETRATES VISCERAL PERITONEUMS SURGICAL MARGINS FREE OF TUMOR WITH NEAREST MARGIN 8 CM FROM TUMOR, RADIAL AND PROXIMAL METASTATIC ADENOCARCINOMA PRESENT IN 15 OF 22 REGIONAL LYMPH NODES WITH EXTRACAPSULAR EXTENSION Icdc3 SEE COMMENT FOR SYNOPTIC REPORTS dii i a ienurrr N6S S/4c/3 C . WEDGE BIOPSY LIVER #2: METASTATIC COLONIC ADENOCARCINOMA JJ #/2]/ COMMENT(S) SURGICAL PATHOLOGY CANCER CASE SUMMARY - CAP APPROVEDS Specimen: Terminal ileum. cecum. appendix. ascending colon Procedure: Right hemicolectomy Tumor Site: Right (ascending) colon Tumor Size.. 5 cm in greatest dimension. Macroscopic Tumor Perforation:. Not identified Histologic Type: Adenocarcinoma Histologic Grade: Low-grade Microscopic Tumor Extension: Tumor penetrates to the surface of the visceral peritoneum (serosa) Margins: Distance of invasive carcinoma from closest margin: 8cm. ** CONTINUED ON NEXT PAGE **
+
+--- Page 2 ---
+PAGE 2 RUN DATE RUN TIME RUN USER PATIENT: (Continued) SPEC #: COMMENT(S) (Continued) Specify Margin: Proximal and radial Treatment Effect: No prior treatment Lymph-Vascular Invasion: Present Perineural Invasion: Not identified Tumor Deposits: Present Pathologic Staging: Primary Tumor: pT4a Regional Lymph Nodes:pN2b Number examined: 22 Number involved: 15 Distant Metastasis: pMl; liver GROSS DESCRIPTION: The specimen is received in the fresh state from the operating room in three parts A.  This is a piece of tan tissue measuring 10 x 10 x 2 mm. totally examined by frozen section as block Al. B.  This specimen. received in the fresh state from the operating room for immediate gross evaluation for evaluation of surgical margins and tumor banking is a right hemicolectomy specimen. The colon measures 24 cm in length by 6 cm in maximum diameter: the terminal ileum measures 6 cm in length by 2 cm in diameter: the appendix measures 7 x 0.8 cm Present in the ascending colon is a circumferential, tan tumor which measures 5 x 5 x 5 cm distal margin.  Tissue of the overlying visceral peritoneum is puckered suggestive of.  Regional adipose visceral peritoneal penetration. Blue ink is applied to these regions.. tissue attached to the specimen measures 15 x 13 x 3 cm. A representative section of the tumor is submitted for tumor banking. Multiple regional lymph nodes are positive for metastatic tumor. the largest measuring 1.5 cm in greatest dimension and exhibiting extracapsular extension of the tumor. The following sections are submitted: B1 appendix and proximal margin B2 distal margin B3-6 - colon mass with blue ink on abnormal visceral peritoneum B7 colon mass B8.9  whole lymph nodes B10-12- representative sections of positive lymph nodes  Portions of the tissue C. This is a wedge biopsy of liver measuring 1 x 1 x 0.5 cm.. appear to be replaced by tumor. A representative section is examinsd by frozen section as block C1. All remaining tissue is submitted as block c2.. INTRAOPERATIVE CONSULTATION: A. FROZEN SECTION DIAGNOSIS WEDGE BIOPSY LIVER #1: FIBROSIS B IMMEDIATE GROSS EVALUATION RIGHT HEMICOLECTOMY: ** CONTINUED ON NEXT PAGE **
+
+--- Page 3 ---
+RUN DATE: PAGE 3 RUN TIME: RUN USER SPEC #: PATIENT: (Continued) INTRAOPERATIVE CONSULTATION: (Continued) ADENOCARCINOMA SURGICAL MARGINS FREE OF TUMOR SPECIMEN PROCESSED FOR TUMOR BANKING C FROZEN SECTION DIAGNOSIS WEDGE BIOPSY LIVER #2: METASTATIC ADENOCARCINOMA PHOTO_DOCUMENTATION Image Picture Copy Error Image Picture Copy Error Image Picture Copy Error Image Picture Copy Error Image Picture Copy Error Signed (signature on file). ** END OF REPORT ** s n|3|I3
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diff --git a/output/text/9e2e9421-b84f-4abc-8841-22b5673372ad.txt b/output/text/9e2e9421-b84f-4abc-8841-22b5673372ad.txt
new file mode 100644
index 0000000000000000000000000000000000000000..421e2cf8283f8d6fc008a726db25c3c054c28541
--- /dev/null
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@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+ics-0-3 uro+liul,NOs g12of3 Carcnomna, 12/30/0 Si$i Cd b1nddr,N0s Cb7 9 h SURGICAL PATHOLOGY REPORT Reformatted Report Patient Name: Accession #: Med. Rec. #: Date of Procedure: DOB: (Age: 72) Location: Date of Receipt: Gender: M Service:  Urology Date of Report: Ref. Physician: Account #: Patient Address: Billing Type: Additional Copy to: Ret. Source: Other Related Data: Billing Type: INPATIENT Financial Number: Clinical Diagnosis & History:. Specimens Submitted: 1: SP: Right distal ureter ! 2: SP: Left distal ureter 3: SP: Bladder and prostate () 4: SP: Right vas deferens 5: SP: Left vas deferens 6: SP: Left pelvic lymph nodes  7: SP: Right pelvic lymph nodes' 8: SP: Right distal ureter . DIAGNOSIS: UUID:6A32EB34-E83A-4665-8DEA-F4CEB7CBF52D 1) URETER, RIGHT DISTAL; BIOPSY: TCGA-DK-A1AC-01A-PR Redacted - SEGMENT OF BENIGN URETER. 2) URETER, LEFT DISTAL; BIOPSY:  SEGMENT OF BENIGN URETER. 3) BLADDER AND PROSTATE; CYSTOPROSTATECTOMY: - HIGH GRADE INVASIVE UROTHELIAL CARCINOMA.  NO EVIDENCE OF TUMOR MULTICENTRICITY IS IDENTIFIED. NO IN SITU CARCINOMA IS IDENTIFIED. THE TUMOR INVADES INTO THE PERIVESICAL SOFT TISSUES (pT3b). LYMPHOVASCULAR INVASION IS PRESENT IN THE PROSTATE. ALL SURGICAL MARGINS ARE FREE OF TUMOR. - ADENOCARCINOMA OF PROSTATE. THE GLEASON'S GRADE IS 3+3=6/1O. THE TUMOR INVOLVES THE FOLLOWING QUADRANT(S) : RIGHT POSTERIOR, RIGHT ANTERIOR AND LEFT ANTERIOR. NO PERINEURAL INVASION IS IDENTIFIED. MULTICENTRIC FOCI OF INVASIVE CARCINOMA ARE PRESENT.  THE TUMOR IS CONFINED TO THE PROSTATE. THE SEMINAL VESICLES ARE FREE OF TUMOR. ALL SURGICAL MARGINS ARE FREE OF TUMOR.  THE REMAINING PROSTATE SHOWS THE FOLLOWING ABNORMALITY(IES): PROSTATIC INTRAEPITHELIAL NEOPLASIA (PIN). THE PATHOLOGIC STAGE (AJCC 1997) IS: pT2b. 4) VAS DEFERENS, RIGHT; RESECTION: - SEGMENT OF BENIGN VAS DEFERENS. Page 1 of 5
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT 5) VAS DEFERENS, LEFT; RESECTION: - SEGMENT OF BENIGN VAS DEFERENS. 6) LYMPH NODES, LEFT PELVIC; DISSECTION: - ELEVEN LYMPH NODES, NEGATIVE FOR TUMOR (O/11).: 7) LYMPH NODES, RIGHT PELVIC; DISSECTION: - ELEVEN LYMPH NODES, NEGATIVE FOR TUMOR (O/11). 8) URETER, RIGHT DISTAL; EXCISION: - SEGMENT OF BENIGN URETER. i ATTEST THAT THE ABOVE DIAGNOSIS !S BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL). AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. *** Report Electronically Signed Out *** Gross Description: 1) The specimen is received fresh for frozen section, labeled. "Right Distal Ureter". It consists of a 0.3 x 0.2 cm tubular piece of tan-pink soft tissue. The specimen is entirely frozen and subseguently submitted for permanent sections. Summary of Sections: FSc - frozen section control 2) The specimen is received fresh for frozen section, labeled. "Left Distal Ureter". It consists of a 0.3 x 0.2 cm tubular piece of tan-pink soft tissue. The specimen is entirely frozen. and subsequently submitted for permanent sections. Summary of Sections: FSc - frozen section control 3) The specimen is received fresh, labeled "Bladder and Prostate". It consists of a 24 x 14 x 5.8 cm cystoprostatectomy specimen with attached overlying adipose tissue. The left half of the prostate is inked blue and the right half is inked green. In the left half of the bladder there is a palpable tumor mass which appears to occupy the left lateral and anterior wall. The. overlying adipose in this area is inked black. There is approximately 3 cm in length of ureter on the left and 4.5 cm of ureter on the right. Both ureters are probe patent. The specimen is opened along the anterior wall to reveal a 7.5 x 6.8 x 3.3 cm, fungating, ulcerated tumor mass occupying the central. and lateral left posterior bladder wall as well as the anterior bladder wall. The tumor is left lateral and anterior and is adjacent to, but not occluding, the left ureteral orifice within. the bladder. The uninvolved bladder mucosa is hemorrhagic and rugose. The trigone is not grossly involved by tumor. Serial sectioning of the tumor reveals the cut surfaces are yellow-white. and necrotic. The tumor invades the muscularis mucosa, however,. Page 2 of 5
+
+--- Page 3 ---
+SURGICAL PATHOLOGY REPORT it does not appear to extend through it into the overlying soft. tissue. Representative sections of tumor and bladder mucosa are submitted. The entire prostate is submitted from anterior to The specimen posterior and designated A through H respectively. is photographed and portions of tumor are submitted to Tps. Summary of Sections: PU - prostatic urethra LUO - left ureteral orifice LUM - left ureteral margin RUM - right ureteral margin RUO - right ureteral orifice LLAT - left lateral bladder post - posterior bladder mucosa. TRIG  trigone DOME - dome TLL tumor left lateral T tumor ST  soft tissue overlying tumor RSVD right seminal vesicle and vas deferens. LSV left seminal vesicle RVD right vas deferens RA right segment A LA left segment B RB right segment B LB left segment B RC right segment c LC left segment C. RAD right anterior segment D RPD right posterior segment D LAD left anterior segment D LPD left posterior segment D RAE - right anterior segment E RPE right posterior segment E LAE - left anterior segment E LPE left posterior segment E F,G,H - serially sectioned prostate. 4) The specimen is received in formalin, labeled "Right vas deferens". It consists of a right vas deferens measuring 9.5 cm. in length and 0.4 cm partially surrounded by fibroadipose tissue.. The specimen is submitted representatively. Summary of Sections: SM - surgical margin RS - representative sections. 5) The specimen is received in formalin, labeled "Left vas in length and 0.4 cm partially surrounded by fibroadipose tissue. The specimen is submitted representatively. Summary of Sections: Page 3 of 5
+
+--- Page 4 ---
+SURGICAL PATHOLOGY REPORT SM  surgical margin RS  representative sections 6) The specimen is received in formalin, labeled "Left pelvic It consists of multiple irregular pieces of lymph nodes". yellowish tan fibroadipose tissue measuring 5.5 x 3.0 x 2.0 cm in aggregate which contains several lymph nodes. The specimen is submitted entirely. Summary of Sections: U - undesignated 7 The specimen is received in formalin, labeled "Right pelvic lymph nodes". It consists of multiple irregular pieces of yellowish tan fibroadipose tissue measuring 5.0 x 5.0 x 1.0 cm in aggregate which contains several lymph nodes. The specimen is submitted entirely. Summary of Sections: U - undesignated 8) The specimen is received in formalin, labeled "Right distal It consists of a portion of ureter which is surrounded ureter". by reddish tan fibroadipose tissue measuring 1.0 cm in length and At one end of the specimen is oriented up to 0.4 cm in diameter. The specimen is submitted entirely. by a suture. Summary of Sections: ST - tip with suture - other tip. RS - middle portion Summary of Sections: SiteBlocks Pieces All Part Sect. 1 Y 1 FSC 1 1 FSC 1 1 N DOME F 1 1 G 1 1 1 1 H LA 1 1 LAD 1 LAE 1 1 LB 1 1 1 1 LC LLAT 1 1 1 1 LPD 1 1 LPE 1 1 LSV 1 11 LUM 2 2 LUO Page 4 of 5
+
+--- Page 5 ---
+SURGICAL PATHOLOGY REPORT LVD 1 1 1 POST 1 1 PU RA 1 1 1 1 RAD 1 1 RAE 1 1 RB RC 1 1 1 1 RPD RPE 1 RSVD 1 2 14 1 RUM RUO 2 2 ST 1 1 5 5 T TLL 1 TRIG 1 1 2 N RS 1 4 SM 1 2 1 2 N 5 RS 1 2 SM M Y U 6 6 m Y 7 U 6 1 2 Y 8 RS 1 1 ST 1 1 T Intraoperative Consultation: The diagnoses given in this section pertain only to the Note: tissue sample examined at the time of the. intraoperative consultation. BENIGN. 1) FROZEN SECTION DIAGNOSIS: SAME. PERMANENT DIAGNOSIS: BENIGN. 2) FROZEN SECTION DIAGNOSIS: SAME. PERMANENT DIAGNOSIS: END OF REPORT  Page 5 of 5
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diff --git a/output/text/9e5020a8-f807-41a7-afd9-f05c3db38f49.txt b/output/text/9e5020a8-f807-41a7-afd9-f05c3db38f49.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2e7b871ca2f20f07aed4ac2a5af199256fcb7195
--- /dev/null
+++ b/output/text/9e5020a8-f807-41a7-afd9-f05c3db38f49.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+DIAGNOSIS Left kidney.radical nephrectomy (A-F): Renal cell carcinoma, see synoptic report. Kidney:Nephrectomy, partial or radical Synopsis MACROSCOPIC Specimen Type: Left radical nephrectomy Focality:Multifocal Tumor Size Greatest dimension:3.1 cm. Macroscopic extent of tumor: Tumor limited to kidney.. MICROSCOPIC Histologic Type: Chromophobe renal cell carcinoma. Histologic Grade: G2: Nuclei slightly irregular. approximately 15 microns: nucleoli evident EXTENT OF INVASION
+
+--- Page 2 ---
+Primary Tumor: pT3a: Tumor directly invades perirenal and /or renc beyond Gerota's fascia. Regional Lymph Nodes: pNX: Cannot be assessed. Lymph Nodes: None submitted Distant metastasis: pMX: Cannot be assessed Margins: Margins uninvolved by invasive carcinoma Adrenal gland:Uninvolved by tumor. Venous invasion: Present (see note) Additional Pathologic Findings: Inflammation (type): chronic inflammation of renal parenchyma. Comments: Areas of hemorrhage and infarction are noted. The tissue is somewhat disrupted where the tumor abuts the renal sinus. Nevertheless there appears to be focal invasion into soft tissue of the renal sinus, therefore the tumor is as reviewed the case. Clinical: Specimen submitted: Left kidney: Clinical diagnosis and data: Left kidney mass Gross: The specimen is received fresh labeled with the patient's name,. the medical record number and "left kidney" it consists of a kidney with attached perinephric adipose tissue that measures 21 x 10 x 7 cm. A segment of ureter is present and measures 5 cm in length. An adrenal gland is present and measures 4.5 x 2 x 0.3 cm. A probe is passed into the ureter. and the ureter is opened longitudinally to the pelvis: the kidney is then bivalved through the pelvic caliceal system.A tumor that measures 3.1 x 2.4 x 1.9 cm is present in the upper pole of the kidney. The cut surface of the tumor is solid yellow. Tumor invasion into the perinephric adipose tissue is not identified. Invasion of the renal vein is not identified. No other lesions are noted in the renal parenchyma. The mucosa of the ureter and pelvis are unremarkable. The adrenal gland is serially sliced and no abnormalities are noted. Representative sections are submitted as follows: A = tumor in relation to the capsule and perinephric fat, B = tumor in relation to adjacent kidney, C = most viable appearing tumor substance. D = section of the kidney away from the tumor. E = ureteral and vascular resection margin. F = section from the adrenal gland..
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diff --git a/output/text/9e550a27-fd27-4c7c-bae3-65fad2d7ed10.txt b/output/text/9e550a27-fd27-4c7c-bae3-65fad2d7ed10.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1a0943b833add275d60855063bb688e9921bd912
--- /dev/null
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+297A2F TCGA-WT-AB41-01A-PR Redacted SuRgiCAL PATHOLOgy REPOrT  NAME: SURG PATH #: Mr #: SPECIMEN CLASS: BILLING #: ALT ID #: LOCATION: DATE OF PROCEDURE: AGE: SEX: DATE RECEIVED: DOB: TIME RECEIVED: PHYSICIAN: DATE OF REPORT: COPY TO: DATE OF PRINTING: IcD0:3 Material Received: A: left axillary sentinel lymph node #1 blue 'aentno uyltiotiigut4os 85oc/3 B: left axillary sentinel lymph node #2 blue C: left breast total mastectomy D: 8 o'clock additional medial short superior , long anterior, clip true margin E: 8 o'clock additional inferior short anterior, long lateral clip true margin Jt-J 8/3o|4 F: 8 o'clock additional anterior short superior, long lateral, clip true margin. G: 8 o'clock additional posterior short superior, long lateral, clip true margin H: additional skin left breast blue at 3:00 History: year old female with a clinical history of breast cancer. Final Diagnosis: A. Lymph node, "left axillary sentinel lymph node #1 blue", biopsy:. Micrometastatic mammary carcinoma (0.23 mm) identified on permanent and pancytokeratin immunostained sections only. See comment. B. Lymph node, "left axillary sentinel lymph node #2 blue', biopsy:. There is no evidence of malignancy (0/1). Deeper sections and a pancytokeratin immunostain are negative in support of the above diagnosis.. C. Breast, "left breast total mastectomy", mastectomy: Invasive ductal carcinoma, moderately differentiated, nuclear grade 2, two foci (measuring 1.2 cm and 1.8 cm in greatest dimension respectively). See comment. D. Fibroadipose tissue, "8 o'clock additional medial short superior , long anterior, clip true margin", reresection:. No diagnostic abnormalities. There is no evidence of malignancy E. Fibroadipose tissue, "8 o'clock additional inferior short anterior, long lateral clip true margin", reresection:. No diagnostic abnormalities There is no evidence of malignancy. F. Fibroadipose tissue, "8 o'clock additional anterior short superior, long lateral, clip true margin", reresection:.  No diagnostic abnormalities There is no evidence of malignancy. G.  Skeletal muscle and adipose tissue, "8 o'clock additional posterior short superior, long lateral, clip true margin", reresection: MR #: Page 1 of 5 Date of Printing: SURGICAL PATHOLOGY REPORT Order Number
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+SURGICAL PAIHULOGY REPORI NAME: SURG PATH #: MR #: ALT ID #: No diagnostic abnormalities. There is no evidence of malignancy. H. Skin, "additional skin left breast blue at 3:00", reresection: No diagnostic abnormalities. There is no evidence of malignancy. Comment: INVASIVE CARCINOMA OF THE BREAST Specimen Type:  mastectomy Laterality:  left Tumor Site: iower inner quadrant at 8:00 and mid outer quadrant at 3:00  Histologic Type: Invasive ductal carcinoma Size of Invasive Component: 1.2 cm in greatest dimension (8:00) and 1.8 cm in greatest dimension (3:00) Tumor Multicentricity: Present (2 foci as noted above)  Surgical Margins: Final margins are negative for carcinoma. In the mastectomy, the 8:00 focus is within 0.1 cm of the inferior, medial and anterior margins and within 0.2 cm of the deep margin; however the separately submitted additional medial, inferior, anterior and posterior margins (specimens D through G) are negative for carcinoma. Histologic Grade (Nottingham Histologic Score):  IIII Tubule Formation: 3 Nuclear Grade: 2 Mitotic Count (40x objective): 1 Total Nottingham Score:  6/9 Ductal Carcinoma In-situ (DCiS): Present, focal, intermediate nuclear grade, without necrosis Lobular Carcinoma In-situ (LCIS): Absent Lymph-Vascular Invasion: Present, focal Perineural Invasion: not identified Tumor Necrosis: not identified Nipple Involvement: not identified Skin Involvement: not identified Lymph Node Sampling: Sentinel lymph node(s) only Total number of involved nodes/total nodes found: 1 micrometastasis out of 2 nodes. Size of largest metastasis: 0.23 mm Extranodal extension: not identified Fixation to one another: Non-neoplastic Breast Tissue: not identified Treatment Effect (Response to Presurgical Neoadjuvant Therapy): In the Breast: In the Lymph Nodes: Prognostic markers: See for addendum on prior biopsy Fixation Time between 6-48 hours: Yes Pathologic Staging: pT2N(sn) 1miM(not applicable) Primary Tumor (Invasive Carcinoma) (pT) pT1: Tumor 20 mm in greatest dimension pT1c: Tumor >10 mm but 20 mm in greatest dimension Regional Lymph Nodes (pN) (sn): Only sentine! node(s) evaluated. If 6 or more sentinel nodes and/or nonsentinel nodes are removed, this modifier should not be used. pN1mi: Micrometastases (greater than 0.2 mm and/or more than 200 cells, but none greater than 2.0 mm). Distant Metastasis (M) Not applicable MR Page 2 of 5 Date of Printing: SURGICAL PATHOLOGY REPORT
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+SURGICAL PATHOLOGY REPORT NAME: SURG PATH #: MR #: ALT ID #: The pathologic stage assigned here should be regarded as provisional, as it reflects only current pathologic data and does not incorporate full knowledge of the patient's clinical status and/or prior pathology. The final diagnosis has been communicated via electronic mail to. by Attestation: By this signature, I attest that I have personally formulated the final interpretation expressed in this report and that the above diagnosis is based  upon my examination of the slides and/or other material indicated in this report. ***Electronically Signed Out By*** Interpreted by: Gross Description: A. Received fresh labeled with the patient's name and "left axillary sentinel lymph node #1 blue" is an irregular portion of red-tan fibroadipose tissue.  The tissue is palpated to reveal one possible lymph node measuring 2.8 x 2.5 x 1.3 cm. The specimen is serially sectioned and submitted entirely in cassettes A1FS and A2FS for frozen and permanent diagnosis. B. Received fresh labeled with the patient's name and "left axillary sentinel lymph node #2 blue" is an irregular portion of red-tan fibroadipose tissue. The tissue is palpated to reveal one possible lymph node measuring 2.5 x 1.8 x 1.0 cm. The possible lymph node is serially sectioned and submitted entirely in cassette B1FS for frozen and permanent diagnosis.. C.  Received fresh labeled with the patient's name and "left breast total mastectomy short superior/long lateral" is a 650 gram. simple mastectomy specimen measuring 20.5 x 18 x 3.5 cm. There is a short stitch marking superior and a long stitch marking ateral.  The breast is serially sectioned to reveal a 1.2 x 1.2 x 0.8 cm tan-pink stellate mass that is 22.5 cm from the lateral margin,. abutting the medial margin, 8.4 cm from the superior margin, abutting the inferior margin, 0.2 cm from the superficial margin, and 0.2 cm from the deep margin. The mass is located in the lower inner quadrant at approximately 8:00.  The deep resection margin is inked black and the superficial resection margin is inked blue. The medial margin of the mass is inked orange and the inferior margin of the mass is inked green. A second tan-white stellate mass measuring 1.8 x 1.5 x 1.4 cm is located 6.5 cm from the Iateral margin, 13.6 cm from the medial margin, 13.6 cm from the superficial margin, 8.3 cm from the inferior margin, 2.4 cm from the superficial margin/skin and 3.7 cm from the deep margin. The mass is located in the mid outer portion of the specimen at approximately 3:00. The remainder of the breast parenchyma is yellow-white and unremarkable. The specimen contains a tan-brown skin ellipse measuring 7.2 x 4.5 cm. The nipple measures 1.4 x 1.3 x 0.6 cm.  There is no dimpling or skin retraction identified.  The breast is placed in formalin at The specimen is submitted as follows: C1 Lower inner quadrant mass to medial margin.. C2-C4 Remainder of lower inner quadrant mass (to superficial, deep and inferior margin). C5-C6 Second mass to deep margin (bisected).. C7-C8 Second mass to superficial margin/skin (bisected).. C9-C14 Remainder of second mass C15 Representative section from upper inner quadrant. C16 Representative section from lower inner quadrant. C17 Representative section from lower outer quadrant. C18 Representative section from upper outer quadrant. C19 Nipple (serially sectioned). C20 Skin. D. Received in formalin labeled with the patient's name and "8:00 additional medial, short superior, long lateral, clip true" is a 2.6 x 1.9 x 1.0 cm lumpectomy specimen, with a short suture designating superior, a long stitch designating anterior, and clips designating the true (medial) margin. The specimen is received as follows:  Anterior - orange Posterior - black True (medial) - green Lateral - blue The specimen is serially sectioned from superior to inferior to reveal a tan-yellow, glistening cut surface. No discrete lesions are identified. The specimen is submitted entirely from superior to inferior in cassettes D1 through D4. The breast was placed in formalin at MR Page 3 of 5 Date of Printing: SURGICAL PATHOLOGY REPORT
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+SURGICAL PATHOLOGY REPORT NAME: SURG PATH #: MR #: ALT ID #: E. Received in formalin labeled with the patient's name and "8:00 additional inferior short anterior, long lateral, clip true margin" is a 3.0 x 2.3 x 1.1 cm lumpectomy specimen, with short suture designating anterior, long suture designating lateral, and clips marking the true margin. The specimen is inked as follows: Anterior - orange Posterior - black Superior - blue True (inferior) - green The specimen is serially sectioned from medial to lateral to reveal a yellow-gold, glistening cut surface. No discrete lesions are identified. The specimen is submitted entirely from medial to lateral in cassette E1 through E4. The breast is placed in formalin at F. Received in formalin labeled with the patient's name and "8:00 additional anterior short superior, long lateral, clip true margin" is a 3.2 x 1.7 x 0.3 cm lumpectomy specimen, with short sutures designating superior, a long stitch designating lateral, and clips designating the true (inferior) margin. The specimen is inked as follows: True (anterior) - orange Posterior - black Medial - green Lateral - blue The specimen is serially sectioned from superior to inferior to reveal a yellow, glistening cut surface. No discrete lesions are identified. The specimen is submitted entirely from superior to inferior in cassettes F1 through F3. The breast is placed in formalin at G.  Received in formalin labeled with the patient's name and "8:00 additional posterior short superior, long lateral, clip at true margin" is a 2.1 x 1.9 x 0.6 cm lumpectomy specimen with short sutures designating superior, a long set of sutures designating Iateral, and clips designating the true margin. The specimen is inked as follows: Anterior - orange  True (posterior) - black Medial - green Lateral - blue The specimen is serially sectioned from superior to inferior to reveal a tan-pink to tan-brown cut surface. No discrete lesions are grossly identified. The specimen is submitted entirely from superior to inferior in cassettes G1 through G3. The specimen is placed in formalin at H. Received in formalin labeled with the patient's name and "additional skin left breast blue at 3:00" is a 5.0 x 5.0 cm C-shaped  portion of tan-brown skin and subcutaneous tissue with an attached strip of brown skin measuring 13.9 x 0.3 x 0.5 cm. The skin on the specimen was inked blue in the OR and designates 3:00. The remainder of the specimen is inked as follows: 12 to 3:00 - orange 3 to 6:00 - purple 6 to 9:00 - blue 9 to 12:00 -- green Deep-black The specimen is serially sectioned from 12 to 6:00, and no discrete lesions are identified. Also received within the container are two irregular portions of tan-brown skin and subcutaneous tissue measuring 1.4 x 0.6 x 0.6 cm and 8.6 x 0.3 x 0.5 cm. This tissue is serially sectioned and no discrete lesions are identified. The specimen is submitted as follows: H1 - Representative sections from the 12 to 3:00 margin H2-H4 -  Representative sections from the 3 to 6:00 margin H5 - Representative sections from the 6 to 9:00 margin H6 - Representative sections from the 9 to 12:00 margin H7-H8 - Representative sections from the additional skin and underlying soft tissue Intraoperative Consultation: A1FS, A2FS, lymph node, "left axillary sentinel lymph node #1 blue" Negative for carcinoma. MR Page 4 of 5 Date of Printing: SURGICAL PATHOLOGY REPORT
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+SURGICAL PATHOLOGY REPORT  NAME: SURG PATH #: Mr #: ALT ID #: B1FS, lymph node, "left axillary sentinel lymph node #2 blue":. Negative for carcinoma.  If immunohistochemical stains and/or in situ hybridization are cited in this report, the performance characteristics were determined by the in compliance with CLIA'88 regulations. Some of these tests rely on the use of "analyte specific reagents" and are subject to specific labeling requirements by the FDA. Known positive and negative control tissues demonstrate appropriate staining. This testing was developed by the It has not been cleared or approved by the FDA. The FDA has determined that such clearance or approval. is not necessary. lw 1|au\1y MR Page 5 of 5 SURGICAL PATHOLOGY REPORT Date of Printing:
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diff --git a/output/text/9e68138b-7b05-4098-a8ac-c52d0cce8654.txt b/output/text/9e68138b-7b05-4098-a8ac-c52d0cce8654.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f75c824ecb24fb94902425de44375ad188ad0283
--- /dev/null
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+/c s-0-3 Curcinoma hpatoclluln N0s 817o13 S,ts: lwi Caa.0 1/24f1 li Patient Key: Surgical date:.  TISSUE DESCRIPTION: l A2 B1 Cl D1 E1 E2 Fl F2 F3 F4 F5 F6 F7 tallbladder (8.0 x 3.5 x 2.8 cm), peritoneal biopsies (No.l, 3 mm; No.2, 3 mm), peri choledochal lymph node (2.0 x 1.0 x 0.8 cm), and right adrenal gland (5.82 grams, 6 x 3.7 x 1.5 cm), right lobe liver (2,680 grams, 27.5 x 19.5 x 12.5 cm), and cystic duct lyuph node (0.6 x 0.5 x 0.4 cm). DIAGHOSIS: Liver, right lobe, hepatectomy: Grade 3 (of 4) hepatocellular carcinoma, usual type, forming a dominant 16 x 15 x 13 cm mass with innumerable satellite nodules ranging in size from 0.5 cm to 6 cm. The tumor is located in the right lobe. The hepatic capsule is involved, but adjacent organs spared. The surgical margins are involved grossly. Extratunoral vascular invasion is identified, involving portal veins microscopically. The tumor is partially encapsulated, infiltration of parenchyma being of infiltrating type. A single separately submitted periportal lymph node is negative for tumor. Information regardiny the uninvolved hepatic parenchyma will be reported in an addendum. Adrenal gland, right, excision: Metastatic grade 2 (of 4) hepatocellular carcinoma forming multiple (2) separate masses (l.4 x 1.3 x 1.1 cm and 0.4 x 0.3 x 0.3 cm). Gallbladder, cholecystectomy: Chronic cholecystitis with cholesterolosis. Negative for tumor. Peritoneal, No.l and No.2, biopsies: Negative for tumor. Lymph nodes, cystic duct and pericholedochal, excision: A single ystic duct lymph node and a single pericholedochal lymph node are negative for tumor. ADDENDUM: The non-neoplastic liver is non-cirrhotic and shows changes that are likely related to adjacent mass effect. No ground-glass hepatocytes are seen. UUID:F8B8C948-933A-4B28-A0D1-98166C9B16EF TCGA-DD-A119-01A-PR Redacted
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+1cs-0-3 Carcinome, hepatcellulery N0s 8r7o/3 S.te: lwu cox.0 1/24/11 Patient Key: Surgical date: I TISSUE DESCRIPTION: J6 Al A2 Bl Cl Dl El E2 F1 F2 F3 F4 F5 F6 F7 Gallbladder (8.0 x 3.5 x 2.8 cm), peritoneal biopsies (No.l, 3 mm; No.2, 3 mm), peri choledochel lymph node (2.0 x 1.0 x 0.8 cm), and right adrenal gland (5.82 grams, 6 x 3.7 x 1.5 cm), right lobe liver (2,680 grams, 27.5 x 19.5 x 12.5 cm), and cystic duct lymph node (0.6 x 0.5 x 0.4 cm). DIAGNOSIS: Liver, right lobe, hepatectomy: Grade 3 (of 4) hepatocellular carcinone, usual type, forming a dominant 16 x 15 x 13 cm mass with innumerable satellite nodules ranging in size from 0.5 cm to 6 cm. The tumor is located in the right lobe. The hepatic capsule is involved, but adjacent organs spared. The surgical margins are involved grossly. Extratumorel vasculer invasion is identified, involving portal veins microscopically. The tumor is pertially encapsuleted, infiltration of parenchyma being of infiltrating type. A single separately submitted periportal lymph node is negative for tumor. Information regarding the uninvolved hepatic perenchyma will be reported in an addendum. Adrenal gland, right, excision: Metastetic grade 2 (of 4). hepatocellular carcinone forming multiple (2) separete masses (l.4 x 1.3 x 1.1 cm and 0.4 x 0.3 x 0.3 cm). Gallbladder, cholecystectomy: Chronic cholecystitis with. cholesterolosis. Negative for tumor. Peritoneal, No.l and No.2, biopsies: Negative for tumor..  Lymph nodes, cystic duct and pericholedochal, excision: A single negative for tumor.. ADDEHDUM: The non-neoplastic liver is non-cirrhotic and shows changes that are. likely related to adjacent mess effect.  No ground-glass hepatocytes are seen.
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+Liver - Digcstive Systtm CAP Approved * Data clemcnts with asterisks are not required for accreditation purposes tot the Commission on Cancer. These elements may be clinically important, but are not yel validatcd'or reyularly used in palicnt manageinent.. Alternatively, the necessury dutu may not be availuble to the pathologist at the time of pathologic assessment of this specimen. LIVER: Resection Puticnt name: (to be de-identified) Ptient Key Surgienl puthokgy ounber. Suigery Det : MACROSCOPIC Spgcimen Type V Right lobeclomy Extended right lobectomy Mediad segmentectoiny Left lateral segmerlectomy Total left lobectomy Explanted liver Other (specify): Not specilied Focality Solitary (spccily location): V Multiple (specify locution): mht (-he (osnQ.ocm) Tumor Size Grealesi dimension:(b. cm. *Additional dimensions: (x 13m Cannot be determined (see Comment) MICROSCOPIC Histologic Type  Hepatocellulur carcinoma Fibrolamellar heputocellular carcinoma variant (specity):. Combined hepatucellulur and cholangiocarcinoma Cholangiocarcinona, intrahepatic Bile duct cystadenoxarcinoma Undifferentiated carcinoma Other (specify): Careinoma, typc cunnot be determined Histologic Grade Not applicable GX: Cannot be assessed GI: Well differentiated GII: Moderately differentiated GHI: Poxurly ditferentiated GIV: Undifferentiated/anupluslic Other (specify):
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+Ment K Pg2 Puthologic Staging (pTNM) Primary Tumor (pT) pTX: Cannot be assessed pTO: No evidence of primary lumor pT1: Solilary tumor with no vascular invasion.  pT2: Solitary tumor with vascular invasion or multiple tumors none more than 5 cm  pT3: Multiple tumors more than 5 em or tumor involving a major branch of the portal or hepatic vein(s) pT4: Tunor(s) with direct invasion of adjacent organs other than the gallbladder or perforation ot visceral petitoneum Regional Lymph Nodes (pN)  pNX: Cannot be asscssed Y pN0: No regional lymph node metustasis - pN1: Regional lymph node mctastasis Specify: Number examined: _3 Number involved: Q Distunt Metastasis (pM)  pMX: Cannot be asscssed V pM1: Distant metastasis *Spccity site(s), if known: night Ad renal gl and.  mnd+,ple. Margins (check all that apply) Parenchymal Margin Cannot be assessed  Uninvolved by invasive carcinoma Distance of invasive cureinoma from closcst margin: . mm Specify margin: _ lett narerdhyme resec#m mrg;M  Involved by invasive carcinoma Bile Duct Margin (Cholangiocarcinoma Only) Cannot be assessed Uninvolved by invasive careinoma Cureinoma in situ absent Carcinoma in situ present Involved by invasive carcinoma Other Margin Specify margin: Cannot be ussessed Uninvolved by invasive curcinoma Involved by invasive carcinoma #Venous (Large Vessel) Invasion (V) Absent * Prcsent *Indeterminatc *Additiona! Pathologic Findings (chcck all that apply).  None identitied  Hepalocellular dysplasia Ductal dysplasia * Cirrhosis/fibrosis Iron overload Hepatitis (specify type):.  Other (specify):
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diff --git a/output/text/9e829201-fe45-463a-b448-ee0c25c9b52b.txt b/output/text/9e829201-fe45-463a-b448-ee0c25c9b52b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d558c883cc15b0ec8009dab1fcfcc7b9e716ce8b
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+CcD-o-3 Carc inona,InAitratiy FINAL PATHOLOGIC DIAGNOSIS ducta) N6s 8scf3~ A. Right breast; modified radical mastectomy: Site BBresstNoS - Invasive ductal (tubulo-lobular) carcinoma, SBR grade Il, focally associated 050.9 YJ q|8|13 with microcalcification, see parameters. - Ductal carcinoma in situ, low and intermediate nuclear grade, cribriform, micropapillary and solid type, associated with necrosis and microcalcifications. - Ductal carcinoma in situ is < 2 mm from posterior margin. - Biopsy site changes. UUID:0CA74400-1596-4C14-AF02-4F5169D61942 TCGA-OL-A5RV-01A-PR Redacted - Columnar cell changes.. - Two small fibroadenomas.. - Twenty of twenty-nine lymph nodes, positive for metastatic carcinoma (20/29) - Extranodal extension present. Breast Pathologic Parameters 1. Invasive carcinoma: A. Gross measurement: 4.5 cm (main lesion) and 1 cm (satellite in upper outer quadrant) B. Composite histologic (modified SBR) grade: II - Architecture: 2 - Nuclear grade: 2 - Mitotic count: 2 C. Associated intraductal carcinoma in situ (DciS): - Within main mass (forming 40 % of tumor volume)
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+2. Intraductal carcinoma:. A. Gross measurement: 4.5 cm, admixed with invasive carcinoma B. Type: Cribriform / Solid / Micropapillarye C. Nuclear grade: Low / Intermediate D. Associated features: Necrosis / Microcalcifications / Cancerization of lobules 3. Excisional biopsy margins: - Dcis < 2 mm from posterior (closest) margin - Invasive carcinoma > 4 mm from posterior (closest) margin 4. Blood vessel and lymphatic invasion: Present - Present in breast parenchyma - Present in axillary tissue. 5. Nipple: DciS extending into lactiferous duct 6. Skin: uninvolved. 7. Skeletal muscle: absent 8. Axillary lymph nodes: Positive (20/29) - Size of largest metastatic deposit: 12 mm - Extranodal extension: present (7 mm; largest focus) - Tumor deposits in axillary tissue (up to 5 mm)
+
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+9. Special studies (see - ER: Strong expression in >90 % of invasive tumor nuclei - PR: Strong expression in >90 % of invasive tumor nuclei - Her2/neu antigen (FISH): Non-amplified (ratio:1.00) 10. pTNM (AJCC, 7th edition, 2010): pT2(m), N3, MX Clinical History: The patient is a  year old female, with a right breast mass (MRI: 1.3 x 0.9 x 0.8 cm) and biopsy diagnosis of invasive ductal carcinoma undergoing right. modified radical mastectomy. Specimens Received: A: Right breast; mastectomy Gross Description: A. The specimen is received in a single container labeled with the patient's. name, medical record number, and additionally identified as, 'right breast'
+
+--- Page 4 ---
+Received fresh and placed in formalin is a 653 gm modified radical mastectomy specimen. The specimen is oriented with a short suture designating the superior margin and a long suture designating lateral margin. The specimen measures 18.5 cm from superior to inferior, 22.5 cm from medial to lateral, and 3.9 cm from anterior to posterior. There is an attached 9.6 x 7.9 x 1.5 cm axillary tail. On the anterior surface is a 18.0 x 8.0 cm tannish brown ellipse of skin with a 4.0 x 4.5 cm areola and a 1.5 x 1.4 x 0.5 cm raised nipple. The nipple-areolar complex reveals no evidence of ulceration or retraction.. The specimen is inked as follows: superior edge - blue; inferior edge - green; posterior - black. The specimen is serially sectioned from medial to lateral into 11 slices to reveal a rubbery, irregularly shaped, white-tan, 4.5 x 3.5 x 2.5 cm mass with a granular cut surface in slices 3 through 5. A clip is identified in slice 3. The  mass is 0.5 cm from the posterior margin and widely free (>2 cm) from the  anterior superior and anterior inferiormargins. The remainder of the specimen consists of approximately 30% dense gray-white fibrous breast parenchyma and 70% Iobulated yellow adipose tissue. No additional masses or nodules are grossly. identified. Sectioning through the axillary tail reveals multiple tan-brown, rubbery lymph nodes ranging from 0.3-2.5 cm in greatest dimension. Block summary: A1: mass surrounding clip and closest approach to posterior margin and. surrounding clip, slice 3
+
+--- Page 5 ---
+A2: mass, slice 4 A3: mass, slice 4 A4: mass, slice 5 A5: mass and biopsy site, slice 5. A6: upper outer quadrant, slice 7 A7: lower outer quadrant, slice 6 A8: upper inter quadrant, slice 2 A9: lower-inner quadrant, slice 5 A10: skin adjacent to mass A11: nipple A12: tissue directly beneath nipple A13: one lymph node, sectioned A14: one lymph node, bisected A15: one lymph node, sectioned A16: one lymph node, bisected A17: one lymph node, bisected A18: one lymph node, bisected A19: two lymph nodes A20: two lymph nodes A21: three lymph nodes A22: three lymph nodes A23: one lymph node, sectioned A24: three lymph nodes A25: four lymph nodes A26: three lymph nodes
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diff --git a/output/text/9e8cd2c3-02dc-49fc-8bd4-1aa0b51cdce5.txt b/output/text/9e8cd2c3-02dc-49fc-8bd4-1aa0b51cdce5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..51f9673e915425ae222b51cf7e3a83497d50265d
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+UUID:9441C376-F0CE-4A84-A9C0-5FB1917216F2 TCGA-G3-A7M5-01A-PR Redacted MRN CONFIDENTIAL SurGiCAl pAThOLOgy rEPOrt Time Collected Time Received Time Reported Time Transmitted Order Number Ordering Provider Status Final Relevant Information Location Copied To Report Patient  Name. Demographics (for verification purposes) Date or sirth: Sex. SURGICAL PATHOLOGY REPORT ****Surgical Pathology Report* ICD-o:3 Accession Number Collected Date/Time Cor cunonid, hepatseslulor NoS Received Date/Time 817013 Pathologist Site sLwer CeQD Specimen Description OtI 9/z5/_3 A: Gallbladder B: Right lobe liver Clinical Information Large right lobe liver Ca on CT KUB 16 x 12 x l4 cm Infectious patient:No Immunocompromised: No History of neoplasm: No Diagnosis A: Gallbladder Chronic cholecystitis Cholelithiasis. B. Liver, Right Lobe, Excision: Hepatocellular carcinoma, grade II  Portal vascular inflammation of embolization Resections margins close Adjacent liver with non-specific portal triaditis Reported by: Electronically siqned by: Verified: Synoptic Report B: Liver, Resection, Macroscopic Specimen: Liver
+
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+Page 2 of 3 Gallbladder PROCEDURE: Partial hepatectomy *Major hepatectomy (3 segments or more) TUMOR SIZE: Greatest dimension: 15 cm *Additional dimensions: 14.5 x 8.0 cm TUMOR FOCALITY: Solitary (specify location) : Right lobe B: Liver, Resection, Microscopic. HISTOLOGIC TYPE: Hepatocellular carcinoma HISTOLOGIC GRADE: GII: Moderately differentiated TUMOR EXTENSION (select all that apply): Tumor confined to liver PRIMARY TUMOR (pT) : pTl: Solitary tumor with no vascular invasion. REGIONAL LYMPH NODES (pN): pNX: Cannot be assessed MARGINS: Parenchymal margin uninvolved by invasive carcinoma Distance of invasive carcinoma from closest margin:. 2 mm Specify margin:  parenchymal Bile duct margin uninvolved by invasive carcinoma *VENOUS (LARGE VESSEL) INVASION (V) :) *Absent Gross Description Received are specimen containers A to  all requisitions and specimen containers are labelled with the patient's name, The cassettes and are labelled with the Surgical Number. A:  The specimen is received fresh and is subsequently placed into formalin and labeled. gallbladder.  The specimen consists of a partly collapsed gallbladder measuring 9 cm from. fundus to resection margin by approximately 3 cm in transverse diameter.  The outer peritoneal surface is unremarkable. The lumen contains multiple faceted and mulberry. Shaped dark pigment stones up to 1 cm in diameter..  The residual mucosa is unremarkable. with a green velvety appearance.. The wall measures up to 0.1 cm in thickness.. No cystic duct lymph node is identified. Representative sections from the fundus, mid body, and cystic duct resection margin are submitted in one cassette.  The specimen is received fresh and is subsequently placed into formalin and labeled. right lobe of liver. The specimen consists of a resection specimen of liver tissue weighing 1.570 kg. There is a blue suture attached to the inferior edge. The anterolateral surface appears dusky and discolored with areas of pallor, possibly capsular fibrosis, but without any obvious involvement by tumor. The diaphragmatic area is unremarkable and the left retrohepatic peritoneal surface is unremarkable. There is a this margin and this is painted blue..  The lobe measures 19 cm from superior to inferior,. 18 cm from medial to lateral, and approximately 10 cm from the anterior surface to the deep bare area. Transverse incisions into the liver lobe shows it to be expanded and hemorrhagic cut surface with viable areas of tumor showing a pale yrey to yellow green color.  The tumor itself has dimensions of 14.5 x 8 x 15 cm (photographs has been taken. of the transverse section showing the multilobulated tumor). There is no obvious extension of the tumor into vascular structures grossly, but at. the resection margin,. there is large duct or vascular channel that appears to have a granular material balling up on its lining. This is also visible more distant from the hilar zone of this resection specimen.  Further sectioning shows this to extend to the hilar resection margin. This appears to extend to the painted resection margin at the vascular hilum of the lobe.
+
+--- Page 3 ---
+ Page 3 of 3 Adjacent liver does not show any significant nodularity to suggest underlying cirrhosis. Sections are taken as follows: B1-13. sections at hilum of lobe to illustrate interface between tumor and resection. margin and to. illustrate potential vascular invasion and vascular extension to resection margin 814-16. additional sections of tumor close to rese. ion margin B17-23. tumor in relationship to capsule B24/25. tumor B26-30. sections of surrounding liver parenchyma. Microscopic Description. A.  Sections show gallbladder wall with minimal inflammation but focal areas with. Aschoff-Rokitansky sinuses and mild subserosal fibrosis consistent with mild chronic cholecystitis. No atypia is present.. B.  The resection shows a hepatocellular carcinona that has a somewhat lobulated architecture forming large rounded nodules of tumor. The tumor cells show mild to. moderate nuclear atypia growing in broad sheets of cells, showing focal pseudoglandular areas with accumulation of bile, as well as showing prominent fatty change.  Prominent The HCc closely approaches the painted resection margin,. but direct extension is not present,. with a clear margin that is focally as close as 3.0 and 2.0 mm in two of the sections In multiple areas the granular material appears to involve lareger vascular spaces, with granulatomatous changes in the walls of veins related to intraluminal foreign material consistent with pre-operative embolization.. In smaller portal tracts this is clearly in. the portal venous system. No clear evidence of perineural or vascular invasion can be identified. The adjacent liver parenchyma shows portal triadiris as well as areas of granulomatous inflammation related to portal veins. The portal tracts are mildly expanded, but there is no clear evidence of an underlying cirrhosis or chronic liver disease.. Accession Number Encounter Number Patient Location 3 CISQUALIFH
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diff --git a/output/text/9e9dfd28-baad-47fc-be75-8ac30feba770.txt b/output/text/9e9dfd28-baad-47fc-be75-8ac30feba770.txt
new file mode 100644
index 0000000000000000000000000000000000000000..779e8b7713e845b3ddadfaf2e68371153cedca6e
--- /dev/null
+++ b/output/text/9e9dfd28-baad-47fc-be75-8ac30feba770.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SPECIMEN Splenic flexure please send for K-ras CLINICAL NOTES PRE-OP DIAGNOsIS: Left colon cancer. GROSS DESCRIPTION Received fresh labeled "splenic flexure" is a previously unopened, 15 cm. segment of colon surfaced by smooth, glistening tan-pink serosa with a moderate amount of attached mesocolon. The undesignated margins average 4.6 cm. in circumference. Central palpale mesenteric mass is noted and the overlying surface is inked blue. On opening, there is a central, 3.8 x 3.4 cm. rubbery tan white-pink tumor mass which is equadistantly located 7.5 cm from each of the undesignated margins. On sectioning, the tumor has a maximal thickness of 2 cm. grossly extending into the muscularis to within 0.4 cm. of the inked free radial serosal suface. A portion of tumor and a portion of normal mucosa are submitted for tissue procurement as requested. No additional mass lesion or abnormality is identified. The aforementioned mesenteric mass measures 2.7 cm in greatest dimension with glistening tan-white cut surfaces and appears contigous with the aforementioned mucosal tumor, spanning an overall depth of 3.2 cm. and focally extending to within O.1 cm. of the inked free radial serosal surface (see contiguous sections blocks 5 and 6). The remaining mucosa is unremarable glistening tan pink with regular folds and the wall averages 0.5 cm. in thickness. A few soft to rubbery tan white-pink tissues in keeping with lymph nodes measuring up to 2 cm. in greatest dimension are recovered from the attached mesocolon. Representative sections are submitted in 15 blocks as labeled. Rs-15. BLOcK suMMARy: 1 - Proximal and distal margins; 2-6 tumor full thickness to inked free radial serosal surface (cassettes 5 and 6 represent tumor to mesenteric mass with point of continuity inked green); 7 - random colon; 8 - three whole lymph nodes; 9-12 - one bisected lymph node per cassette; 13-15 - additional ocolon (in lieu of minimal number of nodes normally required).
+
+--- Page 2 ---
+MICROSCOPIC DESCRIPTION Histologic type:  Adenocarcinoma Histologic grade: Moderate to poorly differentiated Primary tumor (pT): Extends to the muscularis propria and into pericolonic tissue (pT3) Proximal margin: Uninvolved Distal margin: Uninvolved Circumferential (radial) margin: Close Vascular invasion: Present. Regional lymph nodes (pN): Metastatic carcinoma is present in 7 of 13 pericolonic lymph nodes (pN2). Non-lymph node pericolonic tumor:. Extensive Distant metastasis (pM):  Could not be evaluated by this specimen. (pMX) Other findings:  None 5 DIAGNOSIS Colon, splenic flexure, resection:. Adenocarcinoma, moderate to poorly differentiated, depth of invasion through muscularis propria.. Surgical margins uninvolved. Metastatic carcinoma present in 7 of 13 lymph nodes DIAG  End Of Report
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diff --git a/output/text/9ec02bc3-0e26-45d0-bee3-2d05e9054f53.txt b/output/text/9ec02bc3-0e26-45d0-bee3-2d05e9054f53.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e64bba13710ffda8c88e297329a106b6d2cd7c74
--- /dev/null
+++ b/output/text/9ec02bc3-0e26-45d0-bee3-2d05e9054f53.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+TCGA-F2-6879 SURGICAL PATHOLOGY Case Number : Diagnosis: FSA: Liver, segment 7, biopsy - Benign liver with canalicular cholestasis, no carcinoma identified. FsB: Liver, segment 3, medial, biopsy.  Benign liver with canalicular cholestasis, no carcinoma identified. Fsc: Liver, segment 2, biopsy - Benign liver with canalicular cholestasis, no carcinoma identified. FSD: Common bile duct margin, biopsy Bile duct, no carcinoma identified.. FsE: Pancreatic duct margin, biopsy. Carcinoma in situ involving pancreatic duct margin, suspicious for stromal invasion. FsF: Pancreatic margin, additional, biopsy  Pancreatic parenchyma and fibrin, no carcinoma identified. - No duct for evaluation. FsG: Pancreatic margin #3, biopsy.  Pancreatic parenchyma and duct, no in situ or invasive carcinoma identified. H: Gallbladder, cholecystectomy - Gallbladder, focal chronic cholecystitis, no stones identified, no carcinoma identified. I: Stomach, duodenum and pancreas, en bloc Whipple resection Tumor histologic Type: adenocarcinoma. Histologic grade: moderately differentiated Tumor size: 4.5 cm
+
+--- Page 2 ---
+Extent of invasion:. - Peripancreatic soft tissues: positive (peripancreatic fat, I5, I6, 115) - Duodenum: wall involved (I11, I12). - Ampulla: wall involved (I11). Lymphatic Invasion: not identified. Venous Invasion: not identified Perineural Invasion: not identified. Surgical margins: - Pancreatic neck: negative (4 mm to inked margin, I13).  Bile duct: negative (I1). : Circumferential/deep: negative (<1 mm to inked margin (I15))  Proximal (gastric): negative (I3, I4).  Distal (duodenal): negative (12) Regional lymph nodes: metastatic adenocarcinoma (2/11), larger metastasis 6 mm diameter, without extracapsular extension.. Additional findings: focal pancreatic parenchymal fibrosis and atrophy, focal peri-common bile duct acute inflammation (l1).. AJCC Stage: pT3 pN1 pMx Note: This pathologic stage assessment is based on information available at the time of this report, and is subject to change pending clinical review and. additional information.. Intraoperative Consult Diagnosis: Frozen sections were requested by Dr. in. year-old with pancreatic head mass.. FSAl: Liver, segment 7, biopsy. - Benign liver with cholestasis, no tumor seen FsBl: Liver, segment 3, medial, biopsy - Benign liver with cholestasis, no tumor'seen. Fscl: Liver, segment 2, biopsy - Benign liver with cholestasis, no tumor seen.
+
+--- Page 3 ---
+FsDl: Common bile duct margin, biopsy No tumor seen FsEl: Pancreatic duct margin, biopsy - At least carcinoma in situ, focally suspicious for invasive carcinoma FsFl: Pancreatic margin, additional, biopsy - Pancreatic parenchyma, no duct for evaluation Fsg1: Pancreatic margin #3, biopsy No tumor seen Frozen Section Pathologist: Clinical History: Not dictated. Gross Description: Specimen A is received fresh for frozen section and is a 7 x 5 x 2 mm red/brown soft tissue fragment, which was frozen as FsAl, NTR. Specimen B is received fresh for frozen section and is a 10 x 7 x 3 mm red/brown soft tissue fragment, which was frozen as Fsbl, NTR. Specimen c is received fresh for frozen section and is a 6 x 1 x 1 mm red/brown soft tissue fragment, which was frozen as Fscl, NTR. Specimen D is received fresh for frozen section and is a 9 x 6 x 4 mm red/brown soft tissue fragment, which was frozen as Fsdl, NTR. Specimen E is received fresh for frozen section and is a 4 x 3 x 2 mm pink/tan soft tissue fragment, which was frozen as Fsel, NTR. Specimen F is received fresh for frozen section and is a 6 x 4 x 2 mm red/tan
+
+--- Page 4 ---
+soft tissue fragment, which was frozen as FsFl, NTR. Specimen G is received fresh for frozen section and is a 2.5 x 0.8 x 0.3 cm red/tan soft tissue fragment, with a stitch on one side indicating the true margin. The surface is inked blue. The specimen was frozen as FSG1, NTR. Specimen H was received in a formalin-filled container labeled "gallbladder". Previously opened: The presumed cystic duct is widely patent. The remainder of the gallbladder appears complete. Measurements: 10.4 x 3.6 x 2.0 cm External surface: Roughened on the hepatic surface, but otherwise pink/tan, subtly discolored green, smooth and glistening and. unremarkable. wall thickness: 2.5 mm on average Mucosa: Green/brown, velvety and unremarkable with no mucosa mass lesions readily identified. Stones present: Not identified Other comments: Gallbladder is partially filled with sticky, viscous dark brown/green bile. This bile is adherent to the mucosa. Block #: H1 Specimen I: Specimen fixation: Formalin Specimen type: Unspecified, but believed to be standard whipple Orientation: Inking: common bile duct/yellow, pancreatic margin/blue, uncinate margin/black, body/green, gastric margin/orange, duodenal margin/red Tumor location: Pancreatic head Gross appearance of tumor: Solid pale yellow/white mass lesion encompassing the majority of the pancreatic head. There are no areas of necrosis, hemorrhage or calcification readily identified.
+
+--- Page 5 ---
+Tumor dimensions: 4.5 x 2.0 x 3.0 cm Extent of invasion: Confined/nonconfined to the pancreas: Grossly the tumor appears to be invading through the duodenal wall and distorting the duodenal mucosal. This. occurs in the areas of the ampulla. Involvement of the ampulla: Not grossly involved. Involvement of the duodenum: Present Involvement of the bile duct: Absent Involvement of adjacent blood vessels: N/A. Spleen (if applicable): N/A Duodenum (if applicable): N/A Gallbladder (if applicable): N/A Stomach (if applicable): Not involved Surgical margins: Pancreas: Blue inked pancreatic surgical margin, focally close Bile duct: Negative. Proximal (small bowel or stomach) margin: Negative. Distal (small bowel) margin: Negative Peripancreatic soft tissues: Green inked pancreatic margin focally close. Lymph nodes: Multiple lymph node candidates are identified from approximately 3 x 3 x 3 mm to 1.0 x 0.6 x 0.4 cm. Other remarkable findings: The gastric serosa is red/tan, smooth and glistening and unremarkable. The gastric wall is 2 mm thick on average and the mucosa is red/tan with normal architecture. The duodenal serosa is red/tan, smooth and glistening and unremarkable. The duodenal mucosa is dark brown/tan, glistening with normal architecture. No duodenal abnormalities are readily appreciated. There is some chalky yellow/white discoloration to the pancreatic parenchyma in the distal pancreas, this may represent fat necrosis.. Digital photograph taken: No
+
+--- Page 6 ---
+Tissue submitted for special investigation: Tumor was given to tissue procurement. Block Summary:. Inking: common bile duct/yellow, pancreatic margin/blue, uncinate margin/black, body/green, gastric margin/orange, duodenal margin/red Il - common bile duct margin en face 12 - duodenal margin en face I3-I4 - majority of gastric margin en face I5-I6 - perpendicular section to blue inked pancreatic body margin I7 - black inked uncinate margin en face I8-I10 - duct from ampulla towards margin, respectively I11 - tumor involving duodenum I12 - additional tumor and duodenum I13 - additional tumor I14-I15 - distal pancreas surrounding adipose tissue (? Fat necrosis present) I16 - stomach. 117 - duodenum I18 - one lymph node candidate from area of common bile duct margin, sectioned I19-120 - one lymph node candidate sectioned (adjacent to inferior pancreas) I21-122 - one peripancreatic lymph node candidate, sectioned 123 - one lymph node candidate, sectioned 124 - one lymph node candidate, sectioned I25 - one lymph node candidate, sectioned I26 - one lymph node candidate I27-129 - additional adipose tissue Light Microscopy: Light microscopic examination is performed by Dr. The frozen section diagnoses are confirmed. Pancreatic duct carcinoma in situ is identified, with associated invasion of pancreatic parenchyma, with extension into peripancreatic fat and wall of duodenum near the ampulla of Vater. Metastatic carcinoma is identified in nodes in blocks I18 and 119.
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diff --git a/output/text/9f02cb45-b2dd-48be-bb9c-884ec88b2bc2.txt b/output/text/9f02cb45-b2dd-48be-bb9c-884ec88b2bc2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..49ad84337bf0453f724903f395e4805eb1110b09
--- /dev/null
+++ b/output/text/9f02cb45-b2dd-48be-bb9c-884ec88b2bc2.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:5F5FF3CA-2DBB-4DE1-9190-1FE36E285ACB TCGA-AN-A0FK-01A-PR Redacted TSS Patient ID: Case # DOB: Sex: Female Ethnicity (Race): Cancer Sample Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma Date of Procurement: Anatomic Site: Right breast Tumor location: Primary Tissue Specification: Tumor Specimen Matrix: Tissue Specimen Format: OCT Container: block Type of Procurement: surgery Grade: 2 T Stage: 4 N Stage: 0 M Stage: 0 Treatment: none Treatment Details: n/a Normal Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw. Matrix: Blood Specimen Format: frozen Container: tubee Date of Procurement 1cs-0-3 carcinomu, lifiHruHny dluct,nivs 85oo/3 Sife : hreast, nus C50.9 lu 10/21)11 yofsft!
\ No newline at end of file
diff --git a/output/text/9f0db108-b62c-4d72-b8eb-f899c618381b.txt b/output/text/9f0db108-b62c-4d72-b8eb-f899c618381b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2d6723f1716d7308a39215c7593286e6c3b8c815
--- /dev/null
+++ b/output/text/9f0db108-b62c-4d72-b8eb-f899c618381b.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+From To. P.833 0. SDE: RIOHT AXILLA, SEntinEL #1, SEntInel nOde aIOPSY E RLLARY LYMPH NODE. NEGATIVE FOR METASTATIC TUMOR (0/1). 1cD-0-3 FAR7 2: Lympm noge, LEft axillA, Sentinel #1, Sentinel node Biopsy -  ONE AXILLARy LYMPH NODE, nEGATIVE FOR METASTATIC TUMOR (0/1). Sit; brast, Nos C50.9 3|13|n h PARt 3: Lymph nOgE, LEFt AXILLA, SEntineL #2, SEnTineL nODe BiOpSY  One Axillary Lymph node. negative for metastatic tumor (0/1). Part 4: Breast, Leet, simple mastectomy' -- Invasive Ductal carcinoma no special type. A. NotTinghAm grADE 3 (tusuLe formation: 3, nUclear PLeOmorphi8m: 3, mITOtic Activity: 2; tOtal Score = 8/9). c.  THe InvAsive tunOr measUre8 APproximateLy 2.0 Cm in LArgest DimensiOn (five COntiguOUs SEcTIoNs). D. THe invASIve CArCiNOMa i8 LOCATeD At THe JUncTIOn Of UPpEr innEr ANd LoWer inNFR QUaDRANTS. E. LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED. F.  ResecTiOn margins are negative for carcinoma. G. The nIppLe I8 NEgative fOR tumor. H. 'The sxin is negative for tumor. CALciFIcatIOns ArE AssOciated wiTh invasIvE CarcinomA AnD BenIgn BReaSt ParEnchymA. S. Atypical Ductal hyperplasia. K. IntraDugtal papillomA.  THE non-NEOpLASTiC BrEAST ShOWs DuCTaL EFITheLAL hYpERpLaSIA, ADEnOSiS AnD FIBrOcySTiC CHANGES. M.  Previous biopsy site change8. N.  THe invasIve tumOr CeLLs ARe POsItIve tOr Cstrogen aND PrOgEsterone RecePtOrs AnD  negative for her-2. as per previous patholocy report :: Part s Breast, Aighe simple magtectomy --  Invasive buctal carcingaa, no special type. A. NOT Tingram grADe 2 (tuBuLe fOrmation: 2. nuclear PleOmorpki8m: 2, MitotiC Actmity: 2; tOTAl ScORe = 6/9). C. D. DUCTAL CARCINOMA IN SITU (DCIS). CRIDRIFORM AND SOLID TYPES WITH MINIMAL NECROSIS. E. The Dcis cOnsTitutes -10% Of the total Tumor mass and is Present Admixed wiTh the Invasive Component. F. LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED G. RFsection margins are negative for CarcinomA. H. The invasive Carcinoma Is LOcateD at The upper Outer QuaDrant. The nippie is negative for tumor. J. THF SKIN I3 NEGATIVE FOR T'UMOR K. AtypIcaI. DUcTal hYpeRpLASIa. tHe nOn-NeOpLASTIC BREAST ShOw8 FIBrOcY8TIC ChAnGe8 witH ASSOciATED MICROCALCIFICATIONS. M.  Previous siopsy site changeS. THE INVASIVE TUMOR CELLS ARE POSITIVE FOR ESTROGEN AND PROGESTERONE RECEPTORS AND N. Negative for her-2, as Per previous pathology report CASE SyNOPSIS:  SyNOPTic - pRImARy iNvaSIvE.CARCinOmA OF BREAST Lateraiity: ion ProceDure. Simple masternmy LOcATION: Upper immer quarant SIZE OF TUMOR: Lower inner quudrant MULTICENTRICITY/MUL TIFOCALITY OF INVASIVE FOCI: Maxinuin dimension invasive rnnponent: 2.0 cm TUMOR TYPE (invasIve cnmponent): No nOttingham scOrE: Duclal adenorarcinona. NO Nuclr grade:  Tubule tormatlon 3 Mitolic activity acore. 2 Tolal Nordngham scure: 8. AngIOLyMPHA IIC InVASION: Nuttingham grade (1. 2. 3). 3 Yes Dermal Lymphatic InvAsiOn: CALCIFICATION: NO Yes. benign zoncs UUID:C7587286-2260-41C3-9E21-91E4F52AD7EA SURGICAL MARGINS INVOLVED SY INVASIVE^COMPONENT: Yes. mallgnant zones TCGA-BH-A0DO-01A-PR Redacted LyMPH NODES POSITIVE: No I. YmPh NODES ExAMINEO: 0 method(s) of Lymph nooe exAmination: 2 1l/E st3n SKIN INVOLVEO (ULCERATION): NON-NEOPLASTiC BREAST TISSUE: ADH. Papiluma, FCD  No 1 stage, pathologic: N stage, PathologIC: pT1c M Stage. PathologiC: pNO Estrogen receptors: DMX Progesterone receptors: xusilive HER2/NEU: ryeilive zoro or 1+ se k
\ No newline at end of file
diff --git a/output/text/9f1512fd-34a7-46e3-b79e-159c1f7374ed.txt b/output/text/9f1512fd-34a7-46e3-b79e-159c1f7374ed.txt
new file mode 100644
index 0000000000000000000000000000000000000000..dcd6a605e3405598c75dd91a2756d702386cdb1a
--- /dev/null
+++ b/output/text/9f1512fd-34a7-46e3-b79e-159c1f7374ed.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+P.14 Confidentia! UUID:8731CB50-7625-4848-9858-AF17BDA31F2A tcgA-T3-a92m-01a-pr Redacted Icdo 3 S.te; darfryNbs 032.1 J)3/2wj1 4 Site ID: Subject Number: Please complete ALl information with black ball ooint nen. Ensure infarmation is legible. Retain original and email/fax copy to Sample Collection Date: Procured by: D.MMM. Time of Tumor Sample Excision Time Zone: (24 hour clock): H HMM TUMOR-FROZEN & FRESH SAMPLES  FROZEN'SAMPLES'SATCH SHIPPED (dry ice); FRESH TUMOR SAMPLE; IF COLLECTED, SHIPPED ON DAY OF COLLECTION Collect resected tumor in accordance with standard procedures. Weigh the sample and section off ~1oomg. Frozen Tumor (Required) Place this sample in the cryovial labeled Frozen Tumor sample and record the welght. Placa the cryovial in a cane and then into the vapor phase dewar. Record the time placed in dewar. Time placed in dewar: (tissue weight must be  1c0mg) (24 hour clcck) HH-M-M Fresh Tumor (Optional) O N/A Locate the "Fresh Tumor' label in the kit and affix to the 15m!. tube (sent separately). Place any remaining. tumor tissue into the 15ml conical tube containing. 100 Weight of Tissue: mg Time placed in Lot Number of (no min. weight specified) (24 hour clock) H HMM WHOLEBLOOD.SAMPLE(RequIred)-BATCHEDSHIPPED.FROZEN(dC Procured by: -- Sample Collection Date: D.MMM.YYy. Time of Blood Sample Collection Time Zone: (24 hour clock): H:M M 1-10ml EDTA tube. Fill tube completely and mix by gentle inversion at least 8-10 times. Freeze sample on dry ice or place in vapor phase dewar. Time placed in dry ice/dewar: (24 hour clock) HHM M BASIC PATHOLOGICAL INFORMATION Source of Specimen: haRUAY Clinical Dlagnosis: ARULK Caneer (Ex. Lung Cancer) Confidential Page 1 of 2 Valid fror
+
+--- Page 2 ---
+Confidential Tissue/Blood Requisition Forme Site ID: Subject Number: Diagnostic Slides(Required)SLIDEs BATCHED SHIPPED(ambl From the diagnostic FFPE block, cut 3 slides with one section ~ 4-5um on each slide. Label the frosted tip of the slide in pencil with the sample ID (located on the label at the top of this form). Record the ID number of the diagnostic histology cassette and the number of slides. H&E stain the slides and store in a slide mailer.. Diagnostic Histology Cassette ID Number of Slides Cut. Refento itudyManual for detailed specimen processing andshippinginstructions(rdenotesrequited samples) Specimen Collection Vessel Transfer Tube Shipping Status Frozen Tumor* None Cryovial Same Day-- Dry Ice Frozen Blood* 1-1Oml EDTA None Same Day-- Dry Ice  Fresh Tumor None 15ml- Same Day -- Refrigerated Diagnostic slides* Histology Cassette SuperFrost Slides 5-Slide Mailer---Batch H WhenFRozeN-andFRESH samplesare ready for shipment please notify by Emallnotificatlo At-this time, please also.provide-your Sample.Manifest. Vhen-theDlagnostic slidesareready for shipment plea Emailnotiflcatlon. At this ne,please also provide your SampleManifest. DONOT RETURN EMPTYCONTAINTERS TO White copy-Retaln-for your Records Yellow.copy-send to pathologyfordiagnostieslld Confidential Valid from Page 2 of 2
+
+--- Page 3 ---
+P.01 Page 1 of 3 SurgicalPathology FinalRepor Temporary Copy Case:: Collected: Ordered by.. Final Diagnosis Total laryngectomy and partial pharyngectomy: Moderately-differentiated squamous cell carcinoma.. Histologic grade: G2.. Tumor site: Glottic, subglottic, supraglottic. Tumor size: 4.1 cm. Tumor laterality: Predominantly right-sided. Tumor extent: Tumor invades through the outer cortex of the thyroid cartilage. Margins: See below.. AJCC Pathologic stage: pT4a pN2c Inferior anterior tracheal margin, excision with frozen section: No invasive.or in situ carclnoma is identified. Right lateral pharyngeal wall margin, excision with frozen section: No invasive or in situ carcinoma is identified. Left lateral pharyngeal wall margin, excision with frozen section: No invasive or in situ carcinoma is identified. Mucosa base of tongue margin, excision with frozen section:. No invasive or in situ carcinoma is identified. Right level 2B lymph nodes: Three (3) of three (3) lymph nodes are involved by metastatic. carcinoma. Extracapsular extension Is present.. All nodes are less than 3 cm in size. Left level 2A lymph nodes: One (1) lymph node is present and is involved by metastatic. carcinoma. Extracapsular extension is present. The node is 1.7 cm in size.. Salivary gland:. Benign salivary gland tissue..
+
+--- Page 4 ---
+P.02 Page 2 of 3 Surgical Patholagy FlnalRepor. Temporary Copy. Gase,: Collected Ordered by:. Clinical Information Laryngeal cancer. Frozen Section Diagnosis. Time in: Time out: FSB, Right lateral pharyngeal margin: Mild dysplasia with HPV effect. Negative for invasive carcinoma. FSC, Left lateral pharyngeal wall margin: Negative for malignancy.. FSD. Inferior anterior tracheal margin: Negative for malignancy.. FSE, Mucosal base of tongue: Negative for malignancy. Operating Room Consultation. Time in: Tims out: Tissue for Received is a laryngectomy specimen. Margins closest to mass inked. Submucosal tumor samples for Gross Description. 'A. . Total laryngectomy and partial pharyngectomy." Received is a 7.7 x 5.2 x 4.6 cm larynx. The tracheal margln will. be inked orange. Attached to the right side of the larynx is a 3.0 x 2.1 cm portion of pharynx. The pharyngeal soft tissue margin has been previously inked black. The tracheal and pharyngeal margins will be shavad and submitted in toto. There is a 4.1 x 3.4 cm mass which grossly appears to be in the wall of the right side of the larynx. The anterior aspect of the larynx  adjacent to this mass to include a 4.1 x 3.5 x 1.5 cm right lobe of thyroid will be inked yeliow. The mass grossly appears to abut the anterior aspect of the right side of the larynx. The mass does not grossly appear to extend into the attached portion of. right lobe of thyroid. The mass grassly appears to be confined to the submucosa of the larynx and does not grossly appear to involve the right ar leff vocal cords. The cut surface of the portlon of attached lohe of thyroid is red-tan and no masses ar. Iesions are grossly identified in the portion of attached thyroid lobe. "A1," left half of tracheal margin; "A2." right half of trachea! margin; "A3," left pharyngeal soft tissue margin: "A4." posterior pharyngeal soft tissue margin; "A5." right pharyngeal soft tissue margin; *A6-A7." full-thickness sections of the mass: ("A6." tracheal mucosa aspect: *A7," anterior wall of trachea aspect to include portion of lobe of thyroid): *A8," mass to Include anterior aspect of trachea; "A9." random sections of mass with subglottic portion of attached tracheal mucosa: "A10," right true and false vocal cords; "A11," anterior commissure; "A12." left true and false voca! cords; "A13,* lett pyriform sinus: 'A14," epiglotis; "A15," right pyriform sinus. "B, FsB." Received is frozen section control tissue. Tea bag. "Fsb," all. "C. Fsc." Received is frozen section control tissue. Tea bag. "Fsc. all.. "D, FsD." Received is frozen section control tissue. "FsD." all.. "E, FsE." Raceived is frozen section control tissue. "FsE.," all.. "F, Right level 28." Received are 3 tan tissue fragments ranging from 1.0 to 1.4 cm in greatest dimension. On sectioning. there are 3 possible lymph nodes ranging from 0.8 to 1.1 cm. Random sections af all of the lymph nodes will be submitted. "F," representative.. "G, Left level 2A." Received is a 1.7 x 1.3 x 0.6 cm lymph nods. The cut surface is gray-tan. The specimen will be bisected and submitted in toto. "G," all.. "H, Salivary gland." Received is a 4.1 x 2.5 x 1.5 cm salivary gland. The specimen wil be inked black. The cut surface of the. gland is tan and lobulated. No masses or lesions are grossly identified on the gland. "H1-H3," representative.
+
+--- Page 5 ---
+P.03 Page 3 of 3 Surgical Pathology Final Report Temporary-Copy Case: Collected Ordered by: H. /2/13/13 Ha0?
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diff --git a/output/text/9f245ff4-eb22-4c14-92d3-4a28c6fdc828.txt b/output/text/9f245ff4-eb22-4c14-92d3-4a28c6fdc828.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7a3c88ec336937614913ce945d3e46350004f5cf
--- /dev/null
+++ b/output/text/9f245ff4-eb22-4c14-92d3-4a28c6fdc828.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1cD-0-3 CuGn0mu mfilhntpg oucHl, no5 85cs|3 PuM Sih: brsot, yoq C5o.4. 1/25/11 lw CQu Srts: buot,Nos c5s.9 Diagnosis: , 1. Poorly differentiated invasive ductal carcinoma (tumor diameter: 3.5 cm; minimum distance dorsally 1 cm, other margins remain free) Tumor classification for left,breast: NOS, G IIl, pT2N0LOV0R0 UUID:6E136F3D-A6E1-4541-AA4B-65BC5872DE06 Redacted
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diff --git a/output/text/9f30a93b-85bf-40e4-b41e-6bb9d91ca0ca.txt b/output/text/9f30a93b-85bf-40e4-b41e-6bb9d91ca0ca.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f87506fc8dcf314a097eb525c6845d08df9f7275
--- /dev/null
+++ b/output/text/9f30a93b-85bf-40e4-b41e-6bb9d91ca0ca.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TCGA #: "ample ID #. Diagnosis: Right hemicolectomy preparation tumor-free resection margins, several tubular colon adenomas of the mucous membrane with up to moderate dysplasia (synonymous: mild intraepithelial neoplasia), with several more recent mucosal ulcerations and displaying status post excision of further adenomas of the colon mucosa (compare previous findings xxxxxxxxxxx and xxxxxxxxxxxxx) and with inclusion of a colorectal double carcinoma characterized as an ulcerated, moderately differentiated type of adenocarcinoma in the ascending colon and in the transverse colon (8 cm and 29 cm aborally of the ileocecal valve), both with invasion of the lamina muscularis propria, and with invasion of the lymphatic vessels and with a total of three local lymph node metastases (G2, pT2 L1, V0 R0, pN1 3/21). ics-0-3 aclenocaucioma, Nos814o/3 SrtL : asCndug Cofon C18 2 pw 3|o/ UUID: DDD08E2A-0318-4488-B96B-74697603B470 Redacted A-A01C-01A-PR
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diff --git a/output/text/9f41632e-38e9-4941-b808-4cb0f20b612e.txt b/output/text/9f41632e-38e9-4941-b808-4cb0f20b612e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5bb38abc339b4094cb2325cb255a6b87c8e2384d
--- /dev/null
+++ b/output/text/9f41632e-38e9-4941-b808-4cb0f20b612e.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+Encounter Date: Results SURGICAL PATHOLOGY Patient Info Sex DOB Results UUID:7FF8C90D-50A3-435B-B3C9-306DC4973DC9 TCGA-GV-A6ZA-01A-PR Redacted Specimen #: Submitting Physician: FINAL DIAGNOSIS 1. Left distal ureter, excision (A) - Markedly denuded ureter.. - Negative for neoplasm.. 2. Right distal ureter, excision (B) - Ureter negative for dysplasia and/or neoplasia. 3. Right pelvic wall, biopsy (c) - Benign fibromuscular tissue with myxoid changes. 4. Urethral margin, excision (D) - Urethra negative for dysplasia and/or neoplasia 5. Pelvic lymph nodes, excision (E) - Twelve lymph nodes, negative for carcinoma (0/12). 6. Bladder and prostate, radical cystoprostatectomy (F) - Invasive. high-grade papillary urothelial carcinoma with focal glandular. differentiation. (See comment).  Tumor invades muscularis propria (detrusor muscle). - Cystitis cystica et glandularis with mucinous metaplasia. - Ureteral, urethral and soft tissue margins of resection are negative for tumor. 7. Prostate, radical cystoprostatectomy (F) - Minute focus of adenocarcinoma of the prostate, Gleason score 3+3-6. (See comment) - Focal high-grade prostatic intraepithelial neoplasia. - Tumor is confined to the prostate.. - Seminal vesicles are negative for tumor. - Surgical margins of resection are negative for tumor. TcD6:3 8i3s/3 COMMENT 6. Procedure: Radical cystoprostatectomy batt Tumor Size (greatest dimension): 3.5 cm Histologic Type: Urothelial carcinoma with glandular differentiation 9w8fufe3 Associated epithelial lesion: Cystitis cystica et glandularis with mucinous metaplasia Histologic grade (Urothelial Carcinoma, wHo 2oo4/Isup): High-grade. Adenocarcinoma and Squamous Carcinoma: Not applicable. M'croscopic Tumor Extension: Tumor invades muscularis propria (detrusor Page l of 4
+
+--- Page 2 ---
+muscle) Margins: Margins uninvolved by invasive carcinoma Lymphovascular Invasion: Not identified Pathologic Stage (TNM): pT2b N0 MX Number lymph nodes examined: 12 Number lymph nodes involved (any size): 0 7. Procedure: Radical prostatectomy with pelvic lymph node dissection. Prostate Size: 4.5 x 4.0 x 3.0 cm Prostate Weight: N/A Histologic Type: Adenocarcinoma (acinar, not otherwise specified) Gleason score: Primary 3, Secondary 3, Tertiary 0 Total Gleason Score: 6 % of 4 and/or 5: 0% * of 3: 100% Areas of involvement: Right anterolateral mid peripheral zone Principal area of involvement: Right anterolateral mid peripheral zone Focality: Unifocal Proportion (percentage) of prostate involved by tumor: <1% Greatest dimension of larger tumor nodule: 1 mm Treatment effect on carcinoma: Not identified Extraprostatic extension (Epe): Not identified Seminal vesicles invasion (svr): Not identified Margins: Margins uninvolved by invasive carcinoma Lymphovascular invasion: Not identified Lymph nodes: (see above) Diameter of largest lymph node metastasis (mm): N/A Additional Pathologic Findings:  Benign prostatic hyperplasia - Multifocal atrophy with acute and chronic inflammation -- Atherosclerosis of periprostatic vessels Pathologic Stage (pTNM): pT2 NO MX The diagnosis of carcinoma is supported by the failure of immunoperoxidase. staining for p63 to demonstrate basal cells in the atypical glands. ANALYTE SPECIFIC REAGENT (ASR) DISCLAIMER This test was developed and its performance characteristics determined by The U.s. Food and Drug Administration has not approved or cleared this. test; however, FDA clearance or approval is not currently required for clinical use. (Electronic Signature) SPECIMEN SUBMITTED A: LEFT DISTAL URETER B: RIGHT DISTAL URETER C: RIGHT PELVIC WALL D: URETHRAL MARGIN E: PELVIC LYMPH NODE F: BLADDER AND PROSTATE Page 2 of 4
+
+--- Page 3 ---
+Encounter Date: CLINICAL DATA BLADDER CANCER INTRAOPERATIVE CONSULT DIAGNOSISS A. Denuded mucosa. Negative for neoplasm B. Negative for neoplasm. C. Fibrous adhesions, negative for neoplasm D. Negative for neoplasm GROSS DESCRIPTION A. Received fresh for intraoperative consultation labeled "left distal ureter" is tan-brown soft tissue with a lumen measuring 0.5 x 0.2 x 0.2 cm. It is totally submitted as FsAl.. B. Received fresh for intraoperative consultation labeled "right distal ureter" is tan-brown soft tissue with a lumen measuring 1.0 x 0.5 x 0.3 cm. It is totally submitted as FsBl.. c. Received fresh for intraoperative consultation labeled "right pelvic wall" is one piece of tan-red soft tissue measuring 0.6 x 0.3 x 0.2 cm. It. is totally submitted for frozen section as Fsci. D. Received fresh for intraoperative consultation labeled "urethral margin". is one piece of tan-brown soft tissue with a lumen which measures 0.8 x 0.5. x 0.3 cm. It is totally submitted for frozen section as FsDi. E. Received in formalin labeled "left pelvic lymph nodes" are multiple fragments of yellow-tan fibroadipose tissue aggregating to 7.0 x 5.2 x 3.1 cm. Sectioning reveals multiple ovoid tan firm nodules resembling lymph nodes ranging in size from 0.5 to 4.3 cm. The nodules are submitted as follows: E1 five nodules, E2 two nodules, E3 one nodule, E4 one nodule bisected, E5 one nodule bisected, E6-e7 one nodule sectioned, E8-e10 largest nodule sectioned.. F. Received in formalin is a specimen labeled "bladder and prostate". The specimen consists of a urinary bladder, bilateral ureters, prostate, attached seminal vesicles and vas deferentia. The bladder measures 7.5 x 3.0 x 5.0 cm. The exterior surface is covered by a smooth serosal lining at the dome and fibroadipose tissue at the remaining portion. After the bladder is opened, two exophytic tan-brown fungating masses are identified. The first mass involves the left wall and anterior wall and measures 3.5 x 3.0 x 2.5 cm. The second mass involves the right wall of the bladder and measures 3.5 x 2.5 x 2.0 cm. Upon sectioning, the first mass on the left side of the bladder grossly appears to invade into the muscular bladder wall but not through the wall. It does not appear to involve the perivesical adipose tissue. The second mass, located on the right side of the bladder, does not grossly invade into the wall. The dome of the bladder and the posterior bladder mucosa are not involved. A segment of right ureter measures 1.7 cm in length, is patent and unremarkable. A segment of. left ureter measuring 2.7 cm in length is patent and grossly unremarkable.. The prostate measures 4.5 cm transversely, 4.0 cm anteroposteriorly, and 3.0 cm craniocaudally. The capsular surface is smooth. The gland is inked Page 3 of 4
+
+--- Page 4 ---
+Encounter Date: blue on the right and yellow on the left. After fixation, the capsular. surface is retracted and partially detached. The gland is sectioned from apex to base transversely at 3 mm intervals. The cross sections do not reveal a mass. No nodularity is present. The seminal vesicles are unremarkable. Representative sections are submitted as follows: F1 section of urethra, F2 random section of right ureter, F3 random section of left ureter, F4 left wall of bladder with invasive mass, F5 left wall of bladder deep aspect of invasive mass (deep to section F4), F6 anterior bladder with invasive mass, F7-F8 right wall with second mass and deep inked margins, F9 dome, F10 posterior between masses, F1l trigone, F12 prostate right apex, F13 left apex, F14 6 mm right, F15 6 mm left, F16 9 mm right anterior, F17 9 mm left anterior, F18 9 mm right posterior, F19 9 mm left posterior, F20 24 mm right inferior, F21 24 mm left inferior, F22 24 mm right posterior, F23 24 mm left posterior, F24 right seminal vesicle, F25 left seminal. vesicle. The remainder of the prostate is submitted on. per request of as follows: F 26 12 mm right anterior, F27 12 mm left anterior, F28 12 mm right posterior, F29 12 mm left posterior, F30 15 mm anterior right, F31 15 mm anterior left, F32 15 mm posterior right, F33 15 mm. posterior left, F34, 21 mm anterior right, F35 21 mm anterior left, F36 21 mm posterior right, F37 21 mm posterior left. Also, an additional section of left ureter is submitted as F38.. Submitted by: Location: Test performed by: Lab and Collection SURGICAL PATHOLOGY  Lab and Collection Information Result History SURGICAL PATHOLOGY  Order Result History Report. Result Information Result Date and Time Status Provider Status Final result Ordered Status: This result is currently not released to Display Full Result Report Display Order Report 73/13 Page 4 of 4
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diff --git a/output/text/9f448fa0-c66b-4cad-abba-9c1957528b87.txt b/output/text/9f448fa0-c66b-4cad-abba-9c1957528b87.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4d0673d303841849cf73d5609a6fecbe303ff061
--- /dev/null
+++ b/output/text/9f448fa0-c66b-4cad-abba-9c1957528b87.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:BF101C5C-4A5F-4ECC-A8F3-0A9F21315564 TCGA-A4-A5XZ-01A-PR Redacted Sex:Female D.O.B.. MRN #: Ref Physiu SPECIMEN INFC Collected: Received: Reported: SURgiCAL pATHOLOgy REPORT DIAGNOSIS LgDO-3  DIAGNOSIS: Right kidney, nephrectomy: neneI ee|QQ Tumor Characteristics: acinone, yasIloy Histologic type: Papillary renal cell carcinoma, see comment. 824>/B 2. Tumor site: Right kidney. 3. Tumor focality: Unifocal. 4.. . Tumor size: 8.6 x 8.6  8.3 cm. Sit RXidrey NoS Co4.y 5: Macroscopic extent of tumor: Confined.to kidney. 6. Microscopic extent of tumor: Confined to kidney. 7. Nuclear grade: Fuhrman grade 3/4. 9&5|sf13 8. Lymphovascular space invasion: Not identified.. 9. Sarcomatoid features: Not identified.. Surgical Margin Status: 1. Margins uninvolved by carcinoma: Inked surface, ureter, vasculature. 2. Margins involved by carcinoma: None.. Lymph Node Status: No lymph -noded present.. Other: 1. pTNM stage: pT2aNx. Electronic Signature: COMMENTS: Appropriately controlled immunohistochemical stains performed on block #3 show the following results:. Cylokeratin 7: Positive in tumor. CD68: Positive in foamy macrophages present in many papillary cores. These findings along with the morphologic appearance are consistent with a papillary renal cell carcinoma:.  CLINICAL INFORMATION CLINICAL HISTORY:  Preoperative Diagnosis: NONE GIVEN Postoperative Diagnosis: Symptoms/Radiologic Findings:e SPECIMENS: Right kidney SPECIMEN DATA GrOSs DESCrIpTInN: 1 right kidney. Received in formalin is a 613.5 gram nephrectomy specimen with a marked amount of attached yellow.. Container is labeler lobular tat. The kidney is 12.6 x 11.1 x 7.7 cm. The renal capsule is gray-tan, disrupted superiorly in a 4.5 cm in greatest dimensions focus. At the hilum,  bulging from the capsule, there is a 8.6 x 8.6 x 8.3 cm soft, encapsulated mass. A portion of this capsule has been previousty inked in blue and partially.  incised to collect Genomics research tissues: these Genomics tissues are received in yellow. green, and teal tissue cassettes, all labeled with the respectively. Adjacent to the encapsulated mass at the hilurn, and and. patient's narrx there is an attacned 5.7 cm song segment of ureter tnat is up io 0.3 cm in greatest uianreter. The renal artery and vein segments at the margin are short. 3y  t  & ar 'ong. are patent. and unrenarkable for tumor. Upon sectioning. the mass is well defined from the surrounding normat renal sar ercry--a C- z section. the mass 's so- yelow-tan. necrotic and hemorrhagic. The mass does not involve the renal pelvis. The normal renai as follows: A1--renal vein, arteries, and ureter at the  giand is identified. Representative sections are submitted in cassettes labeled  margins; A2--disrupted portion of superior renal capsule; A3 and A4--mass to capsule; A5-A7--mass to renal peivis; A8--mass to normal rena! parenchyma. w 3/12/13 QUALIFIED DISQUA
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diff --git a/output/text/9fb4651e-99be-459b-a0ea-404781c52598.txt b/output/text/9fb4651e-99be-459b-a0ea-404781c52598.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f0c21a0e166e922829d3aab086e5908cef0798bf
--- /dev/null
+++ b/output/text/9fb4651e-99be-459b-a0ea-404781c52598.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+*** Diagnosis / Diagnoses: *** Resectate of the colon (sigmoid colon) with diverticulosis, with tumor-free oral and. aboral resection margins and under inclusion of an ulcerated, moderately differentiated adenocarcinoma with infiltration of the perimuscular fatty tissue. Thirty-seven regional lymph nodes tumor-free, with uncharacteristic reactive changes (G2, pT3 pN0 (0/37) L0 VO RO).
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diff --git a/output/text/9fbcbf7a-4f1d-4e62-a56e-058c6f1eccbd.txt b/output/text/9fbcbf7a-4f1d-4e62-a56e-058c6f1eccbd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..670190da87ececccd855aad1367adccf2175d6b8
--- /dev/null
+++ b/output/text/9fbcbf7a-4f1d-4e62-a56e-058c6f1eccbd.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+TCGA-CS-5393 SURGICAL PATHOLOGY REPORT FINAL DIAGNOSIS: 1. Left temporal parietal tumor: Anaplastic astrocytoma, grade Ill of. IV (WHO scale), see microscopic description, SEE NOTE. Comment: The proliferation index of 7.2% is within the expected range for an. anaplastic astrocytoma, grade IIl.. This diagnostic report has been personally interpreted by the signatory of record.. Microscopic Description: The tumor consists of a moderately pleomorphic and highly. infiltrative proliferation of astrocytes. There are rare mitoses. There is no endothelial proliferation or necrosis. Immunohistochemistry for the proliferation antigen ki67 was performed as follows:Ten 250 x 250 micron fields were counted and the percentage of labeled nuclei determined. Over 1,O00 cells were counted. The proliferation index ranged from 4.4% to 12.5% with an overall average of 7.2%. Frozen Section Diagnosis:. 1. Left temporal parietal tumor: - Glial Neoplasm. Clinical History and Diagnosis:. 3rain Tumor
+
+--- Page 2 ---
+Source of Specimen: 1: Left temporal parietal tumor Gross Description: 1. Left temporal parietal tumor: Received fresh in specimen jar labeled with patient' s name and, "#1 Left temporal parietal lobe" is a 3.5 x 3.0 x 0.5 cm aggregate of tan white soft brain tissue. Less than 50% of the specimen is prepared for frozen section, and the entire. specimen is submitted in four cassettes. Histology Laboratory H&E Immunohistochemistry Notes 1. Quantification of immunohistochemistry assay for ER and PR studies is by the method of 2. Hercept Test (DakoCytomation) Formalin fixed, paraffin embedded. Interpretation follows the manufacturer' s recommendation. Documented by EGFR pharmDx9 Clone 2-18C9 Formalin fixed, paraffin embedded. Interpretation follows the manufacturer' s recommendation. Doucmented by 3. Analyte Specific Reagent (AscR) Disclaimer. The use of one or more reagents in the above tests is regulated as an analyte specific reagent (ASR). These tests were developed and their performance characteristics determined by the Clinical Laboratory of They have not been cleared by the US Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary.
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diff --git a/output/text/9fc43289-b214-4805-915d-ab47102c5567.txt b/output/text/9fc43289-b214-4805-915d-ab47102c5567.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a65a30fad2420b9ee741e59f43ed41bdde8a21e4
--- /dev/null
+++ b/output/text/9fc43289-b214-4805-915d-ab47102c5567.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+SURGICAL PATHOLOGY REPORT DIAGNOSIS DIAGNOSIS Kidney left nephrectomy Tumor Characteristics: 1. Histologic type: Papillary renal cell carcinoma. 2. Tumor site:Left kidney, lower pole. 3.Tumor focality. Unifocal. 4.Tumor size:3.2 x3.0 x3.0 cm. 5. Macroscopic extent of tumor: Tumor limited to kidney. 6. Microscopic extent of tumor: Tumor limited to kidney. Nuclear grade: Fuhrman grade 2 of 4. f. 8. Lymphovascular space invasion: Not identified 9. Sarcomatoid features: Not identified. Surgical Margin Status: Surgical margins including ureter, renal vein, renal artery, and soft tissue are negative for tumor. Lymph Node Status: No lymph nodes received with specimen. Other: Nonneoplastic renal parenchyma shows numerous sclerotic glomeruli and mild to moderate arteriosclerosis. 2.pTNM stage:pT1a NX. COMMENTS:  Histologic sections show a tumor within the left lower pole which has a papillary architecture composed of tumor cells with an oncocytic appearance. Therefore immunohistochemical staining for CD117,vimentin, and cytokeratin 7 is performed on block 1 to exclude an oncocytoma.The tumor is positive for cytokeratin 7 and vimentin and negative for CD117 supporting a diagnosis of a papillary renal cell carcinoma rather than an oncocytoma. CLINICAL INFORMATION CLINICAL HISTORY:S Preoperative Diagnosis: None given Postoperative Diagnosis: Symptoms/Radiologic Findings: SPECIMENS: Left kidney SPECIMEN DATA GROSS DESCRIPTION: The consists of a kidney with attached perinephric fat measuring 20.0 x 16.0 x 6.5 cm and weighs 814 grams. There is no adrenal gland attached to the specimen. The ureter measures 10.0 cm in length and up to 0.5 cm in diameter. On opening the ureter the mucosal surface is light tan. There are is no material or lesions identified within the lumen. The renal artery stump measures 1.5 cm in length and 0.5 cm in diameter and is grossly unremarkable. The renal vein stump measures 1.0 cm in length and 1.5 cm in diameter and is also grossiy unremarkable.At the hilum there are no lymph nodes identified. The soft tissue resected margin is yellow to brown tan slightly shaggy with adhesions. The martin is inked. The kidney is bisected and reveals a circumscribed brown tan hemorrhagic mass within the lower pole measuring 3.2 x 3.0 x 3.0 cm. On sectioning the mass appears grossly confined to the capsule. There is no lesion into the surrounding perinephric fat identified. The mass is within 2.2 cm of the deep margin. The renal cortex is brown tan measuring 0.5 cm displaying a well defined cortical medullary junction. No other lesions are identified. The renal calyces Representative sections are submitted in cassettes s follows:sections from the mass-1 to 4;ureter-5renal art surrounding uninvolved kidney-7, perpendicular sections taken trom the deep margin overlying the mass--8.
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diff --git a/output/text/9fe42f3d-f85c-4bee-bee3-dbf76aec2efa.txt b/output/text/9fe42f3d-f85c-4bee-bee3-dbf76aec2efa.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0ef588448fdf68085c2258d8e883d82496d18b18
--- /dev/null
+++ b/output/text/9fe42f3d-f85c-4bee-bee3-dbf76aec2efa.txt
@@ -0,0 +1,3 @@
+
+--- Page 2 ---
+LARGE INTESTINE TISSUE CHECKLIST Specimen type: Sigmoid colectomy Specimen size: Not specified Tumor site: Sigmoid colon Tumor size: 8.5 x 4.5 x 1.5 cm Tumor features: None specified Histologic type: Adenocarcinoma Histologic grade: Moderately differentiated Tumor extent: Pericolonic tissues Lymph nodes: 0/8 positive for metastasis (Regional 0/8) Margins: Not specified Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None
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diff --git a/output/text/a032615a-4548-4b4a-9303-001f1c84e94d.txt b/output/text/a032615a-4548-4b4a-9303-001f1c84e94d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..eb9daec16964b337900a75978f0a6c8fdc1b8c67
--- /dev/null
+++ b/output/text/a032615a-4548-4b4a-9303-001f1c84e94d.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TCGA #:  Internal Sample ID: Diagnosis: This is material shows a highly to moderately differentiated adenocarcinoma of the colon. (colic carcinoma possibly on the basis of a pre-existing tubulovillous adenoma) with infiltration of the muscularis and lymph and blood vessel invasion (pT2, L1, V1), it also shows free resection margins and a free ligature region and free lymph nodes (pN0),. a chronic appendicitis with partial scarring and. in II) -- corresponding to the clinical data -- a characteristic Meckel's diverticulum. /cD-0 -3 0dnwcavcinonn Nos 814o|3 Si#t: Cecum fOw C9cr) C18.0 hw 3/3o/u UUID:214F6328-B4EE-41CE-A008-B249A9E80269 TCGA-AA-A02Y-01A-PR Redacted
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diff --git a/output/text/a0cca32d-9902-422f-bff3-7850805449f2.txt b/output/text/a0cca32d-9902-422f-bff3-7850805449f2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..95be9540bea11e586e7f010736ab0eddc84f3b25
--- /dev/null
+++ b/output/text/a0cca32d-9902-422f-bff3-7850805449f2.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+SPECIMENS: A. RIGHT COLON SPECIMEN(S):  A. RIGHT COLON GROSS DESCRIPTION: A. RIGHT COLON: The specimen is received fresh and consists of a 14.5 cm segment of cecum and ascending colon and attached mesocolon. A 4.0 cm segment of terminal ileum is attached. The appendix is present and measures 7.0 x 1.0 x 0.5 cm. The serosa is unremarkable. There is a 6.0 x 4.0 x cm polypoid lesion present in the cecum which is confined to the mucosa. The lesion measures approximately 0.6 cm from the ileocecal valve. The tumor abuts the base of the appendix. The remaining mucosa of the colon is unremarkable. The mucosal surface of the small intestine is diffusely nodular suggestive of hypertrophy of the Peyer's patches. Multiple encapsulated nodules are dissected from the surrounding adipose tissue, the largest measuring up to 1.2 cm across. Representative sections are submitted as follows: A1: Proximal margin, A2: Distal margin, A3: Base of appendix including representative section of tumor, A4: Representative section of tumor closest to ileocecal valve, A5: Additional representative section of ileocecal valve, A6-A12: Additional representative sections of tumor, A13: Sections of appendix. A14: Additional representative sections of colon, A15-A16: Additional representative sections of small intestine, A17: Single encapsulated nodule, A18: Single encapsulated nodule, A19: Single encapsulated nodule, A20: Single encapsulated nodule, A21: 2 encapsulated nodules one inked yellow, A22: 4 encapsulated nodules, A23: 6 encapsulated nodules, A24: 3 encapsulated nodules, A25: 3 possible encapsulated nodules, A26: 2 possible encapsulated nodules, A27-28: Multiple possible encapsulated nodules. DIAGNOSIS: A. COLON, RIGHT, HEMICOLECTOMY: - INTRAMUCOSAL WELL DIFFERENTIATED ADENOCARCINOMA ARISING FROM TUBULOVILLOUS ADENOMA SURGICAL RESECTION MARGINS NEGATIVE FOR TUMOR - APPENDIX, NO TUMOR SEEN - TWENTY FOUR LYMPH NODES, NEGATIVE FOR METASTASES (0/24) - SEE SYNOPTIC REPORT AND SEE NOTE. NOTE: A microscopic focus of invasive well differentiated adenocarcinoma involving lamina propria is identified. The rest of the tumor which almost completely submitted for microscopic examination shows only tubovillous adenoma. Selective slides were reviewed by Dr. who concurs with the diagnosis.. SYNOPTIC REPORT - COLON & RECTUM Specimen Type:  Right hemicolectomy Tumor Site: Cecum Tumor Configuration: Exophytic (polypoid) Tumor size: 0.3cm WHO Classification Adenocarcinoma 8140/3 Histologic Grade: G1: Well differentiated Extent of Invasion:  Lamina propria Margins: Margin(s) uninvolved by invasive carcinoma (Proximal, Distal, Radial). Venous/Lymphatic Invasion: Absent Perineural Invasion:  Absent Additional Pathologic Findings: None identified Extent of Resection:  R0: Complete resection with grossly and microscopically negative margins. Lymph Nodes: Negative 0 / 24 Implants: Absent Pathological Staging (pTNM): pT is N O M x  Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition
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diff --git a/output/text/a0d2a29d-2dba-42eb-a2d5-dc81939cac13.txt b/output/text/a0d2a29d-2dba-42eb-a2d5-dc81939cac13.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0b9ef65fdcb9ed7b89140827e0f11df44c438b71
--- /dev/null
+++ b/output/text/a0d2a29d-2dba-42eb-a2d5-dc81939cac13.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UUID:0FF7D013-EAEC-4406-B314-0ECEA7B59E69 rCGA-CC-A7I3-01A-PR Redacted IrB APpROVED Form Revised Clinical Case Report tcD-o3 (For Collertion of Cancerous Tissue) sreerons,heestoeellals Nos 81 70l3 dnar C QQ D Sute : 10/10/3 I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Lunical intormation GENERAL INFORMATION Date of Birth (mm/dd/yy) Height Marital Status Race Temperature Gender Weight  Blood Pressure Heart Rate eoMale  Female HISTORY OF PRESENT ILLNESS Symptoms: YelL 8{a'n j Weighf loK Clinical Findings: Performance Scale (Karnofsky Score):  100 Asymptomatic   80-90 Symptomatic but Fully Ambulatory 50-70 Symptomatic, in bed less than 50% of day  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden  20-30 Bed Ridden CURRENT MEDICATIONS Drug Dose Route Frequency Date (mm/dd/yyyy) To To 1 To To. 1 / To
+
+--- Page 2 ---
+PAST MEDICAL HISTORY Diagnosis/Disease/Disorder/Injury Diagnosis Date Treatment Status OB/GYN HISTORY Menopausal Status Date of First Menses # of Pregnancies  Pre-menopausal  Peri-Menopausal Date of Last Menses # of Live Births  Post-menopausal Birth Control:  Condom  Oral Contraceptive  IUD  Hormone Replacement  Other: Therapy: SOCIAL HISTORY Occupation: Environmental Hazards: Smoking History Current Status TYPE Packs/day Duration When Quit YES NO 4p[dcui Alcohoi Consumption Current Status Type Drinks/day Duration When Quit YES   NO H darnds Idauy! Drug Use. U Current Status TYPE Frequency Duration When Quit  YES NO (vrs) (yr) FAMILY MEDICAL HISTORY Relative Diagnosis Age of Diagnosis LAB DATA Test Result Date Test Result Date HIV Negative  Positive: CEA  Negative  Positive: Hep B RDNegative  Positive: CA 15-3   Negative  Positive: Hep C Negative  Positive: CA 19-9  Negative  Positive: AFP  Negative  Positive: PSA  Negative  Positive: Other: Other:  Negative  Positive: Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+DIAGNOSTIC STUDIES Study  Results Date Ultrasound X-Ray CT x Atmeuy lces Focisre Uss tho lire Endoscopy MRI Biopsy CLINICAL DIAGNOSIS Preoperative Clinical Diagnosis Liver CrssceR Location of Suspected Involved Lymph Nodes Locatlon of Suspected Dlstant Metastasis Clinical Staging. Date of Diagnosis Tz No Mo Stage: Treatment Information SURGICAL TREATMENT Procedure Date of Procedure Resect^m Ele sriaht liven Primary Tumor Organ Detailed Locatlon Size Aiker Raip Lier lZx 6`x.S cm Extension of Tumor Lymph Nodes Description Location of Lymph Nodes # of Lymph Nodes  Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Organ Detailed Location Size Surgical Staging No M Q Stage: NEOADJUVENT THERAPY (Chemo, Radiation, Immuno, Hormonal, or Molecular) Drug/Treatment Dose Route Frequency Date (mm/dd/yyyy) To 1 1 1 To 1 / / 1 To 1 1 1 To 1 Ta / 1 3
+
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+Pathology Form Specimen Information Collected by: Date: Preserved by: Jate 'ime: SPECIMEN TYPE (# of samples provided) Frozen Paraffin Block  Blood/Serum/Plasma Slide Diseased Normal Diseased Normal Diseased Normal  Diseased  Normal 2 2 4 2  Time to LN2 Time to Formalin Time to LN2 min min min PATHOLOGICAL DESCRIPTION Primary Tumor  Organ  Size Extension of Tumor. Distance to NAT Liver lnins ZxOxS cm Aierrl licecr cm Lymph Nodes V Location # Examined # Metastasized Distant Metastasis Organ Detailed Location Size Pathological Staging pT 2. No Mo Stage: I Notes: 4
+
+--- Page 5 ---
+IRB APPROVED Form Revised Fax: Consolidated Pathology Diagnosis Cell Distribution Structural Pattern + Diffuse Streaming Mosaic Storiform  Necrosis Fibrosis Lymphocytic Infiltration  Palisading Vascular Invasion. Cystic Degeneration Clusterized Bleeding Alveolar Formation x  Myxoid Change Indian File Psammoma/Calcification  Squamous Adenomatous + Sarcomatous + Lymphomatous. + Glandular cell Squamoid Cell Round Cell  Large Cell Spindle Cell  Cell Stratification Fibroblast Small Cell  Keratin  Secretion Osteoblast RS Cell/RS Like  Desmosome Intracyt. Vacuole Lipoblast Inflam. Cell Peart  Gland formation Myoblast Plasma Cell Cellular Differentiation:d  Well  Moderate Poor Nuclear Atypla: 0 I I III  Aniso Nucleosis Y Hyperchromatism 0  Nucleolar Prominent X Multinucleated Giant Cell Mitotic Activity Nuclear Grade: F s o3 Dq 69 Uees t8s )1 0* Dr ?0 Final Pathology Report Histological Diagnosis: Hoxat > Ce/ll Cheeinm9 Grade... hv 8/3o/j3 Criteria Yes Comments: Prmary Tumor Stte Discrepancy HIPAA Discrepancy XX Prior Malignancy History Dual/Synchronous Primary Note Case is (circle) Reviewer Initials Date Reviewed Date INTEGRATED REPORT OF FINDINGS 8Y COLLABORATORS AND PATHOLOGISTS -- fOR RESEARCh USE ONLY
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+Ics-0-3 Cani omn nifiltraHug oluitl, nos 850sf3 Sih.Sreot, Nos C50.9 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: FMP/SSN: DOb/Age/Sex: Race: WHITE Taken: Location: Received: Physician(s) : Reported: SPECIMEN: A: RIGHT BREAST B: ADDITIONAL RIGHT BREAST TISSUE C: MUSCLE,LEFT BREAST,DEEP D: LEFT BREAST E: ADDITIONAL LEFT BREAST TISSUE F: RIGHT AXILLARY SENTINEL LYMPH NODE G:  RIGHT AXILLARY SENTINEL LYMPH NODE H: ADDITIONAL LEFT BREAST TISSUE, INFRAMAMMARY CREASE I: LEFT AXILLARY SENTINEL LYMPH NODE J: LEFT AXILLARY SENTINEL LYMPH NODE #2 FINAL DIAGNOSIS: A. BREAST, RIGHT, MASTECTOMY:  INFILTRATING DUCTAL CARCINOMA, GRADE II (3 FOR TUBULE FORMATION, 2 FOR PLEOMORPHISM, 1 FOR MITOSES = 6). TUMOR MEASURES 2.2 X 2.0 X 1.5 CM (GROSS).  MARGINS NEGATIVE FOR TUMOR (APPROACHES 2.O CM FROM DEEP MARGIN).  NO DUCTAL CARCINOMA IN SITU IDENTIFIED.  NO LYMPHVASCULAR INVASION IDENTIFIED. USUAL DUCTAL HYPERPLASIA (A11).  BIOPSY SITE CHANGES. UUID:7D84A145-19AF-48D0-A509-F5724068CB26 UNREMARKABLE SKIN AND NIPPLE. TcGA-A2-A04V-01A-PR Redacted - AJCC STAGE pT2NOMX. B. BREAST, RIGHT, EXCISION: - UNREMARKABLE FIBROADIPOSE TISSUE. - NO EVIDENCE OF MALIGNANCY. C. SOFT TISSUE, DEEP LEFT BREAST, EXCISION: UNREMARKABLE SKELETAL MUSCLE AND MATURE ADIPOSE TISSUE. - NO EVIDENCE OF MALIGNANCY. D. BREAST, LEFT, MASTECTOMY: INFILTRATING DUCTAL CARCINOMA, GRADE II (3 FOR TUBULE FORMATION, 2 FOR PLEOMORPHISM, 1 FOR MITOSES = 6) WITH ASSOCIATED NECROSIS. TUMOR MEASURES 2.2 X 1.8 X 1.8 CM (GROSS). TUMOR ABUTS THE DEEP MARGIN WITHOUT DEFINITIVE INVOLVEMENT (D4). FOCAL ASSOCIATED DUCTAL CARCINOMA IN SITU, SOLID TYPE (D6 AND D7). FOCAL VASCULAR INVASION (D6). BIOPSY SITE CHANGES. Page 1 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 2 ---
+FOR ORFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: FINAL DIAGNOSIS (continued): UNREMARKABLE SKIN AND NIPPLE -AJCC STAGE pT2NOMX. E. BREAST, LEFT, EXCISION: - UNREMARKABLE FIBROADIPOSE TISSUE. F. LYMPH NODE, RIGHT AXILLARY, EXCISION:  NO EVIDENCE OF MALIGNANCY BY HEMATOXYLIN AND EOSIN AND IMMUNO- HISTOCHEMICAL STAINS (O/1). G. LYMPH NODE, RIGHT AXILLARY, EXCISION:  NO EVIDENCE OF MALIGNANCY BY HEMATOXYLIN AND EOSIN AND IMMUNO- HISTOCHEMICAL STAINS (O/5). H. SOFT TISSUE, LEFT INFRAMAMMARY CREASE, EXCISION: - BENIGN BREAST TISSUE. I. LYMPH NODE, LEFT AXILLA, EXCISION: NO EVIDENCE OF MALIGNANCY BY HEMATOXYLIN AND EOSIN AND IMMUNO- HISTOCHEMICAL STAINS (O/2). J. LYMPH NODE, LEFT AXILLA, EXCISION:  NO EVIDENCE OF MALIGNANCY BY HEMATOXYLIN AND EOSIN AND IMMUNO- HISTOCHEMICAL STAINS (O/1). ** Report Electronically Signed Out * CLINICAL DIAGNOSIS AND HISTORY:S white female with synchronous bilateral infiltrating breast caicinoma. FROZEN SECTION DIAGNOSIS: C. SPECIMEN TYPE: CHEST WALL TIME RECEIVED: TIME REPORTED: REPORTED TO: DR. REPORTED BY: DR. # BLOCKS: 2 Page 2 Continued on Next Page. FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 3 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: FROZEN SECTION DIAGNOSIS (continued) : # SCRAPE PREPS: 0 FROZEN SECTION DIAGNOSIS: -NEGATIVE FOR TUMOR BASED ON TISSUE SUBMITTED. GROSS DESCRIPTION: A. Received fresh, labeled with the patient's name,. designated "RIght BREAsT" is a 980 gram simple mastectomy specimen measuring 23.5 cm superior to inferior, 18.0 cm medial to lateral, and 5.1. cm anterior to posterior. The overyling ellipse of nipple bearing skin measures 7.4 x 3.8 cm, and is without gross abnormalities. Ink code: blue-superior/anterior, green-inferior/anterior, and black-posterior. Sectioning reveals a 2.2 x 2.0 x 1.5 cm stellate tumor with a tan, gritty,. and focally hemorrhagic cut surface in the lower outer quadrant, 2.0 cm from the deep margin, and 2.5 cm from the inferior/anterior margin. The remaining tissue is mostly fatty with interspersed lengths of soft, white, parenchyma. Multiple tissue sections are submitted for cBcp protocol with. matching paraffin sections in cassette Al, A2, A3, and A7. Slide key: Al: Skin. A2: Tumor. A3: Tumor. A4-A6: Margins nearest tumor. A7: Fibrosis (central). A8: Nipple.. A9: Upper inner quadrant. Al0: Lower inner quadrant. All: Lower outer quadrant. A12: Upper outer quadrant. 12CF B. Received in formalin, labeled with the patient's name, designated "ADDITIONAL RIGHT BREAST TISSUE" are two fragments of tan-yellow, fibrofatty, non-oriented, soft tissue. The larger measures 11.0 x 9.5 x 3.5 cm. The smaller measures 7.5 x 7.0 x 3.8 cm. The outer portion of both specimens is inked entirely in black. Sectioning reveals a uniform, glistening, yellow, lobular cut surface admixed with a scant portion of white, fibrous appearing connective tissue.. Representative. sections are submitted. Page 3 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 4 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION (continued) : Slide key:. B1-B6: Random sections of larger fragment. B7-B10: Random sections of smaller fragment. 10CF C. Received fresh for intraoperative consultation, labeled with the patient's name, designated "ADDITIONAL CHEST WALL DEEP AT SITE OF TUMOR, LEFT BREAST SHORT SUPERIOR, LONG LATERAL DOUBLE DEEP" is a 7.5 x 3.5 x 0.8 cm fragment of red-brown, soft tissue. The surface appears to be muscle grossly. Sectioning reveals a white, fibrous appearing band 0.3 cm thick, running the length of the center of the specimen parallel to the deep margin. The specimen is inked deep in black, superior in yellow, and inferior in green. The specimen is entirely submitted lateral to medial. Slide key:. c1: Inferior portion of section 1.0 cm from the lateral margin contiguous with c5.. c2: Inferior portion of section submitted for frozen contiguous with C10. 14CF D. Received fresh, labeled with the patient's name, designated "LEFr BReAsT" is a 984 gram simple mastectomy specimen. specimen measures 26.0 cm superior to inferior, 18.0 cm medial to lateral,.  The and 5.8 cm anterior to posterior. The overlying ellipse of nipple bearing. skin measures 7.2 x 3.5 cm, and is notable for an inverted nipple. Ink code: blue-superior/anterior, green-inferior/anterior, and black-posterior.  Sectioning reveals a 2.2 x 1.8 x 1.8 cm tumor with stellate margins, and tan, gritty, hemorrhagic cut surface in the lower outer quadrant abutting the deep margin. The remaining tissue is mostly. fatty with interspersed widths of soft, white parenchyma. Multiple tissue. sections are submitted for cbcp protocol with matching paraffin sections in cassettes D1, D4, and D5. Slide key:. D1: Skin (medial tip). D2-D4: Tumor with margin. D5: Fibrous, upper outer quadrant, 5.0 cm from tumor. D6-D8: Remaining lateral portion of tumor including deep black inked margin. D9: Two sections of nipple. Page 4 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 5 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient:. Specimen #: GROSS DESCRIPTION (continued) : D10: Upper outer quadrant. Dil: Lower outer quadrant. D12: Lower inner quadrant.. D13: Upper inner quadrant. 13cF E. Received in formalin, labeled with the patient's name, designated "ADDITIONAL LEFT BREAST TIsSUE" is an unoriented, yeiiow-tan, fibrofatty fragment measuring 8.3 x 6.5 x 3.5 cm. The entire outer portion of the specimen is inked in black. Sectioning reveals a uniform,. tan-yellow, glistening, lobular, cut surface admixed with widths of soft,. white, parenchyma. Representative sections are submitted. 4C6. F. Received fresh, labeled with the patient's name, designated "RIGHT AXILLARY SENTINEL LYMPH NODE" is a 1.9 x 1.4 x 1.2 cm lymph node with adherent fat. Half of the node is submitted for the cBcp protocol. The remaining half is submitted for paraffin sections. 1c1 G. Received fresh, labeled with the patient's name, designated "RIGHT AXILLARY SENTINEL LYMPH NODE #2" is a 1.4 x 1.3 x 0.8 8cm lymph node with adherent fat. Half of the node is submitted for the cBcp protocol. The remaining half is submitted for paraffin section in G1. The remaining fatty tissue is bisected, and entirely submitted in. cassettes G2 and G3. 3CF H. Received in formalin, labeled with the patient's name, designated "ADDITIONAL LEFT BREAST TISSUE, INFRAMAMMARY CREASE"*is a 9.5 x 7.0 x 4.5 cm fragment of tan-yellow, glistening, fibrofatty, lobulated, soft tissue. The specimen arrives unoriented.  The entire outer portion is inked in black.  Sectioning reveals a smooth, glistening, lobulated, fibrofatty, yellow-tan, cut surface admixed with widths of soft, white parenchyma. Representative sections are submitted.  8cF I. Received fresh, labeled with the patient's name,. designated "LEFT AXILLARY SENTINEL LYMPH NODE" are two lymph nodes with adherent fat measuring 2.2 and 2.0 cm in greatest dimension. Half of the larger node is submitted for the cbcp protocol. The remaining half is submitted for paraffin section in cassette Il. The smaller node is in cassette I2. The remaining fatty tissue is submitted in cassettes I3 through I6. 6CF J. Received in formalin, labeled with the patient's name,. designated "LEFT AXILLARY SENTINEL LYMPH NODE #2" is a 3.2 x 2.0 x 1.2 cm Page 5 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 6 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION (continued) : yellow-tan fragment of fibrofatty, soft tissue. Within the soft tissue there is a single identifiable lymph node measuring 0.9 cm in greatest dimension. The node is submitted in Jl.. The remainder of fibrofatty, soft tissue is submitted in J2. 2C2. b.1atnal SyNchaanu ivistve dute cus Page 6 End of Report FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974S
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+Procurement Dat Laterality:Left, upper outer quadrant Path Report:BREAST TISSUE CHECKLIST ICs-0-3 Specimen type: Lumpectomy cavcinoma ifi1tnuhng 1obulw, NeS Specimen size: Not specified 852013 Srt: buust,N0S 050.9 Tumor site: Breast hs 1f37f1 Tumor size: 2 x 0 x 2.2 cm Grossly evident lesion: Yes Histologic type: Lobular carcinoma. Histologic grade: Moderately differentiated Tumor extent: Not specified Lymph nodes: 0/10 positive for metastasis (Axillary 0/10) Extracapsular invasion of the lymph nodes: Not specified Margins: Uninvolved Nottingham Histologic Score Tubule formation: Not specified 0325C1-54EB-41BF-B77C-D92FADA8D23E JUIDC7 Redacted TCGA-E9-A23T-01A-PR Nuclear pleomorphism: Not specified. Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified. Comments: None
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diff --git a/output/text/a19126e4-7685-4396-bc37-95db095a32cb.txt b/output/text/a19126e4-7685-4396-bc37-95db095a32cb.txt
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+UUID:8C240699-846B-48A3-8436-53C0BCDD7AA3 TCGA-E1-A7YU-01A-PR Redacted Patient.  Surgical Pathology: Fina!,. Surg Path CLINICAL HISTORY: Anaplastic astrocytoma on outside slides. GROSS EXAMINATION: A. "Left temporal brain tumor" (Afl), in formalin. The specimen is a fragment of soft yellow-tan brain which is approximately 2.5 x 2 x 1.5 cm in aggregate dimensions.  A portion of the tissue has been previously submitted as frozen. section AFl.  The frozen section remnant is submitted in Block Al. A small portion of tissue is retained in formalin and the remainder is submitted in Block A2 and A3. B. "Left temporal brain tumor", received fresh. The specimen is several fragments of pink and yellow-tan tissue which are 2 x 1.2 x 0.9 cm in aggregate dimensions. A small portion is retained in formalin and the remainder is submitted in B1. INTRA OPERATIVE CONSULTATION: A. "Left temporal brain tumor": AFl- glioma. MICROSCOPIC EXAMINATION: The specimen submitted as "left temporal brain tumor" consists of multiple portions of brain which is infiltrated by a neoplastic proliferation of malignant glial cells. Cytologically, the predominant pattern in this glial tumor is that of cells with round to oval hyperchromatic nuclei which exhibit a speckled chromatin pattern and punctate chromocenters lacking nucleoli. Mitotic activity is identified in these cells. In addition there is vascular proliferation and focal calcification in areas of tumor degeneration. Another small component of the tumor is characterized by nuclei with elongated spindle cells and hyperchromatic spindle shaped nuclei. Mitotic activity is also identified in this focus of the tumor. DIAGNOSIS: A-B. "LEFT TEMPORAL TUMOR": MIXED ANAPLASTIC OLIGODENDROGLIOMA-ASTROCYTOMA. SEE COMMENT. cOMmeNT: The predominant tumor component of this specimen is an oligodendroglioma and would be considered'a grade IIl oligodendroglioma in Verified by: Date Signed: 1D-03 ligoatrecyloru, cyacle. II 9382/3 J3win, nuyuratiteral C7i.0 ytS s/5ji4 Printed by: : 1 of 1
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+Jcs-0-3 8500/3 Cuvcinonn, iifiltrtinf ducta!, Nos. Sit: B/ust, Nos C50.9 1/2ifu h Diagnosis: Poorly differentiated inyasive ductal carcinoma with focal intraductal components and angioinvasion (maximum microscopic tumor diameter: 4.0 cm) Diagnosis: 1. Ablated (left) breast sample with extensive further invasive and angioinvasive tumor components, as well as foci of further intraductal tumor components in the cavity region of the sample excision (maximum spread: 8 cm). Massive subepidermal carcinomatous lymphangitis of the skin spindle. Dorsal resection margin tumor-free. Comment: The massive subepidermal carcinomatous lymphangitis in the region of the skin spindle could correlate closely with the clinical appearance of an inflammatory carcinoma, aithough there is no ulceration of the skin spindle. This gives rise to the concluding tumor classification NOS, G IlI, pT3N3aL1V1R0 UUID:CA911D90-5DDA-49F1-993F-68FCA77A8558 TCGA-A8-A08X-01A-PR Redacted
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diff --git a/output/text/a22f4564-4d3d-4b03-91ee-7da18cace674.txt b/output/text/a22f4564-4d3d-4b03-91ee-7da18cace674.txt
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+--- Page 1 ---
+UUID:9F96B0B1-2B88-49AE-8D3C-9FED70F1D950 TCGA-S3-AA12-01A-PR Redacted Page 1 of 4 Diagnosis A. LEFT BREAST AND AXILLARY LYMPH NODES, MASTECTOMY AND LYMPHADENECTOMY: - INVASIVE DUCTAL CARCINOMA, GRADE 2, 9.0 CM IN GREATEST DIMENSION. - METASTATIC CARCINOMA ION TWO OF EIGHTEEN LYMPH NODES. - MARGINS OF RESECTION ARE NOT INVOLVED. - SEE SYNOPTIC REPORT AND NOTE. NOTE: biomarkers studies have been ordered and will be reported-in an addendum. B. SKIN OF LEFT BREAST, ADDITIONAL INFERIOR, EXCISION: - SEGMENT OF UNREMARKABLE SKIN. Icd O-3 $eeh3 (Electronic signature) Verifled: Sb YwestNo3 c50.9 Synoptic Report SPECIMEN: SJ cxfz4l14 Total breast (including nipple and skin) PROCEDURE: Total mastectomy (including nipple and skin) LYMPH NODE SAMPLING: Axillary dissection (partial or complete dissection). SPECIMEN INTEGRITY: Single intact specimen (margins can be evaluated) SPECIMEN SIZE: Greatest dimension: 27 cm Additional dimensions: 19 x 11 cm SPECIMEN LATERALITY: Left TUMOR SITE: INVASIVE CARCINOMA: Upper inner quadrant.. Lower inner quadrant Central TUMOR SIZE: SIZE OF LARGEST INVASIVE CARCINOMA: Greatest dimension of largest focus of invasion over 0.1 cm: 9.0 cm. TUMOR FOCALITY: Single focus of invasive carcinoma MACROSCOPIC AND MICROSCOPIC EXTENT OF TUMOR: Skin: Invasive carcinoma directly invades into the dermis or epidermis without skin ulceration. Nipple: DCIS does not involve the nipple epidermis. DUCTAL CARCINOMA IN SITU (DCIS): DCIS is present Extensive intraductal component (EIC) negative (small foci, less than 5% of the entire tumor). ARCHITECTURAL PATTERNS: Cribriform
+
+--- Page 2 ---
+Page 2 of 4 Surgical Pathology Final Report Temporary Copy Case. Patient Collected: ID: Ordered by.. Location NUCLEAR GRADE: Grade II (intermediate) NECROSIS: Not identified LOBULAR CARCINOMA IN SITU (LCIS): Not identified HISTOLOGIC TYPE OF INVASIVE CARCINOMA: Invasive ductal carcinoma (no special type or not otherwise specified) GLANDULAR (ACINAR)/TUBULAR DIFFERENTIATION: Score 3: <10% of tumor area forming glandular/tubular structures NUCLEAR PLEOMORPHISM:  Score 2: Cells larger than normal with open vesicular nuclei, visible nucleoli, and moderate variability in. both size and shape MITOTIC COUNT: Score1 OVERALL GRADE: Grade 2: scores of 6 or 7 MARGINS: Margins uninyolved by invasive carcinoma Distance from closest margin: 15 mm (deep fascial margin) Margins uninvolved by DCIS (if present) Distance from closest margin: 15 mm (deep fascial margin) LYMPH-VASCULAR INVASION: Present DERMAL LYMPH-VASCULAR INVASION:S Not identified LYMPH NODES: Total number of lymph nodes examined (sentinel and nonsentinel): 16. Number of lymph nodes with macrometastases (>0.2 cm): 2 Size of largest metastatic deposit: 3.5 cm EXTRANODAL EXTENSION: Not identified  PRIMARY TUMOR (INVASIVE CARCINOMA (pT): pT3: Tumor >50 mm in greatest dimension. REGIONAL LYMPH NODES (pN): pN1a: Metastases in 1 to 3 axillary lymph nodes, at least 1 metastasis greater than 2.0 mm DISTANT METASTASIS (M): Not applicable MICROCALCIFICATIONS: Present in non-neoplastic tissue CLINICAL HISTORY:S Palpable mass Specimen Source A LT Breast and Axillary Nodes B Additional Inferior Skin Clinical Information
+
+--- Page 3 ---
+Page 3 of 4 Surgical Pathology Final Report Temporary Copy Case. Patient Collected: Ordered by Location Patient with large mass upper Central breast, core biopsy positive. PRE-OP DIAGNOSIS: Left breast cancer POST-OP DIAGNOSIS: Same TYPE OF PROCEDURE: Left mass and axillary node dissection Gross Description. The specimen is labeled "LEFT BREAST AND AXILLARY NODES " and is received in formalin. It consist of mastectomy specimen with lymph nodes weighing 1330 grams and measuring 27 x 19 x 11 cm with brown skin ellipse measuring 24 x 13 cm, containing grossly unremarkable 1.8 cm in diameter nipple. The posterior margin is composed of smooth fascia which is inked black. Superior non-deep margin is inked with red ink and the inferior non-deep margin is inked with bhue ink. The breast is slices in sagittal planes revealing a large well. defined pink-tan lobulated mass measuring 9 x 7 x 6 cm and is located central portion of the breast and extending upper inner and lower inner quadrant. This mass is 1.5 cm away from the deep fascial margin of resection, 1.5 cm from the superior non-deep fascial margin and 2 cm from the inferior non-deep fascia margin of resection. The remaining portions reveal unremarkable yellow mammary fat with streaks of white-gray mammary parenchyma. The axillary fat pad measuring 10 x 10 x 5 cm. On sectioning multiple lymph nodes are identified. The Iargest lymph node is consists of a 2 matted lymph nodes measuring 4 x 3 x 3 cm and is pink tan and firm in consistency for 3.5 cm. Representative sections are submitted as follows: A1 = nipple A2-A5 = mass A 6 -- mass closest deep fascial margin of resection. A7 -- representative sections upper outer quadrant A8 -- representative sections lower outer quadrant. A 9 -- mass with closest skin surface A 10 -- six lymph nodes A 11 = bisection of a single lymph node A 12 -- bisection of a single lymph node A 13 = bisection of a single lymph node A 14 -- bisection of a single lymph node A 15 = bisection of a single lymph node . A 16 = bisectionof a single lymph node A 17 -- bisection of a single lymph node A 18 - bisection of a single lymph node A 19-A 20 - representative sections of 2 matted lymph nodes. Specimen is in formalin more than 6 hours and less than 48 hours Time specimen was removed from the patient: Time specimen was placed in formalin : Ischemic time: 45 minutes. Dictated by:. Special Stains / Slides. 23 H&E
+
+--- Page 4 ---
+Page 4 of 4 Surgical Pathology Final Report Temporary Copy Case: Patient Collected ID. Location. Ordered by Tissue Code
+
+--- Page 5 ---
+Page 1 of 1 Addendum Report Temporary Copy Case. Patient Collected: ID. Ordered by:. Location Addendum Report IMMUNOHISTOCHEMICAL EVALUATION OF ESTROGEN RECEPTORS, PROGESTERONE RECEPTORS, AND HER-2NEU IN INVASIVE MAMMARY CARCINOMA . ESTROGEN RECEPTORS: 99 %, positive, moderate staining intensity. PROGESTERONE RECEPTORS: <1 %, negative, moderate staining intensity. HER-2NEU: SCORE I+, negative.  Immunohistochemical studies were performed on formalin fixed paraffin embedded tissue (Block A4) using the following monoclonal antibodies: Estrogen receptor (Clone SP1), Progesterone receptor (Clone 1E2) and Her-2neu(  Clone 4B5); control sections for HER-2Neu are provided within a kit (score 0 MCF-7, score 1+ T-47D, score 2+ MDA-MB-453, score 3+ BT-474). Detection system used: polymer. Primary antibodies, reagents and control sections for HER-2neu are all provided by All controls show appropriate reactivity. Reactivity of Estrogen and Progesterone receptors is determined based on the percentage of positively stained nuclei of tumor cells. Reference values (CAP accreditation program checklist 2010 and guidelines on webpage): Positive: nuclear staining in 1% or greater than 1% of invasive carcinoma cells. Negative : nuclear staining in less than 1% of invasive carcinoma cells. Staining intensity: is reported as weak, moderate or strong.. HER-2neu reactivity is reported applying the CAP scoring guidelines (CAP accreditation program checklist 2010 and guidelines on webpage): Score 0 - Negative: No immunoreactivity, or faint weak immunoreactivity in <10% of tumor cells but only a portion of the membrane is positive... Score 1 = Negative: Faint weak immunoreactivity in 10% or >10% of tumor cells but only a portion of the membrane is positive. Score 2+ = Equivocal: Weak to moderate complete membrane immunoreactivity in >10% of tumor cells or circumferential intense membrane staining in <30% of cells. Score 3+ -- Positive: More than 30% of the tumor cells must show circumferential intense and uniform membrane staining. A homogeneous (chicken wire) pattern should be present.. Equivocal results for HER-2neu (Score 2+) will be subsequently followed by a reflex dual-color ISH testing. The performance characteristics of these antibodies were determined by the They have not been cleared or approved by the U.S. Food. and Drug Administration. The FDA has determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA-88) as qualified to perform high-complexity clinical laboratory testing. (Electronic signature) Verified:
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diff --git a/output/text/a2373028-01fb-417e-81b5-bdb8f126654c.txt b/output/text/a2373028-01fb-417e-81b5-bdb8f126654c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b169f0403f59da890757eebc8084a6798c30824a
--- /dev/null
+++ b/output/text/a2373028-01fb-417e-81b5-bdb8f126654c.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+*** Diagnosis/Diagnoses: *** 1.: Excision specimen from peritoneum with angiectasia and subserosal fibrosis. 2.: Colonic resection specimen (evidently sigmoid) with an ulcerated carcinoma of the colon of the histological type of a moderately differentiated colorectal adenocarcinoma, measuring 2 cm in its largest diameter and extending to a maximum of 8 cm from the resection margin. Invasive tumor spread to the level of the muscularis propria. Oral and aboral resection margin tumor-free. Twenty-six mesocolic lymph nodes tumor-free and with uncharacteristically reactive changes. Tumor stage therefore pT2 pN0 (0/26) L0 V0; G2 R0.
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diff --git a/output/text/a2552386-5fa3-4cca-bb08-bf2bae7a22e0.txt b/output/text/a2552386-5fa3-4cca-bb08-bf2bae7a22e0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b202c1a578977d5ef63105c83081a7246bdadb61
--- /dev/null
+++ b/output/text/a2552386-5fa3-4cca-bb08-bf2bae7a22e0.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Jcs-0-3 Carcinoma, nifiHnatny ductal, Nos 85os/3 Srhx- brest, Nos C50.9 1/8/ Pathology Form Specimen Information Collected by: Date: ime Preserved by: Date: me: w+*SPECIMENTYPE # of samples ptovided* Frozen Paraffin Block Blood/Serum/Plasma Slide Normal Diseased Normal Diseased Normal Diseased Norma! Diseased x x Time to LN2 Time to Formalin Time to LN2 40 min min min MSHSCMRPAPATHOLOGICALDESCRIPTIONTE PTPS Primary Tumor Organ Size Extension of Tumor  Distance to NAT Reeat 9.5x NO 2.. X cm cm Lymph Nodes Location # Examined # Metastasized Axilla 4 9 Distant Metastasis. Organ Detailed Location Size Pathological Staging pTg N4 Mo Stage: T, Notes: UUID: 28E368DA-56B9-4BB1-99C3-7FF2CEC964CF Redacted TCGA-C8-A12Y-01A-PR 4
+
+--- Page 2 ---
+Microscopic Description sitsHistologicalPattern Structural Pattern + Cell Distribution +  Streaming Diffuse  Mosaic  Storiform  Necrosis Fibrosis  Palisading Lymphocytic Infiltration  Cystic Degeneration Vascular Invasion -  Bleeding Clusterized Alveolar Formation Myxoid Change  Psammoma/Calcification Indian File wsgnsos+qCellular Differentiation'. ..:  Sarcomatous + Lymphomatous  Squamous + Adenomatous +  Round Cell  Large Cell Glandular cell +  Squamoid Cell Small Cell Cell Stratification Fibroblast Spindle Cell  RS Cell/RS Like Secretion Osteoblast  Keratin Inflam. Cell Intracyt. Vacuole Lipoblast  Desmosome  Myoblast  Plasma Cell Pear! Gland formation. Moderate Poor Cellular Differentiation: x Well wahwow.uclearAppearancewwrao 1  II  0 III Nuclear Atypia: +  Aniso Nucleosis + Hyperchromatism Nucleolar Prominent Muitinucleated Giant Cell + Mitotic Activity + Nuclear Grade: a Data Date Result Value Marker ER  Negative  Positive PR  Negative  Positive  Negative   Positive  Her-2/neu  Negative  Positive B-Cell Marker  Negative   Positive T-Cell Marker  Negative  Positive Other: Negative  Positive Other: Final Pathology Report Inrngiie Ductaf Creiuma Histological Diagnosis: Grade: T Comments: in Date Pathologist Principal Investigator
+
+--- Page 3 ---
+COnsOLIDATed DIagnOsTIc pAThOLOgy fORm* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION Diffuse + STRUCTURAL PATTERN Mosaic Streaming Necrosis Storiform Lymphocytic Infiltration XFibrosis Vascuiar Invasion Palisading Clusterized Cystic Degeneration Alveolar Formation Blceding Indian File X Myxoid Change  Psammoma/Calcification 2. Cellular features. Squamous Adenomatous + Sarcomatous Squamoid Cell + Lymphomatous Glandular cel! Round Cell Spindle Ccll Cell Stratification Large Cell Fibroblast  Keratin  Secretion Small Cell Osteoblast Desmosome _RS Cel/RS Like Intracyt. Vacuole  Lipoblast  Inflam. Cell  Pear!  Gland formation Myoblast Otherwise Specified: Plasma Cell S, 607s Dr 6 oT 2.Cellular Differentiation: Well Moderately Poor x Nuclear Atypia: Nuckear Appearance Aniso Nuclcosis Hyperchromatism V Nucleolar Prominente Multinucleated Giant Cell X Mitotic Activity Nuclear Grade Comments: PATHOLOGIST STAFF FOR RESEARCH USE ONLY). NTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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diff --git a/output/text/a2571dec-a908-4e32-81ec-1e46af8740b5.txt b/output/text/a2571dec-a908-4e32-81ec-1e46af8740b5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8cc345795e630150782ab8585ded11bfbf3a4023
--- /dev/null
+++ b/output/text/a2571dec-a908-4e32-81ec-1e46af8740b5.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:4713327E-50FF-4B7F-8F7F-1D024420C840 tcd-o-3 CGA-B9-A5W9-01A-PR Redacted arcinomc., popllares reual cell ! 8468/3 Diagnosis: Site: BKidney NoS A: Kidney, right, partial nephrectomy. C64.9 Qw3/18/13 Procedure: partial nephrectomy. Laterality: right Histologic tumor type/subtype: type I papillary renal cell carcinoma Sarcomatoid features: absent. Histologic grade (if applicable): Grade 3. Tumor size (greatest dimension): 5.7 cm Tumor focality: unifocal Extent of tumor invasion (if present specify if macroscopic or microscopic) : Capsular invasion/perirenal adipose tissue: absent Gerota' s fascia: not applicable Renal sinus: not applicable Major veins (renal vein or segmental branches, Ivc): not applicable Ureter: not applicable. Venous (large vessel): not applicable. Lymphatic (small vessel): absent Histologic assessment of surgical margins: Renal parenchymal margin (partial nephrectomy only): negative Renal capsular margin (partial nephrectomy only): negative Paranephric adipose tissue margin (partial nephrectomy only): negative Gerota' s fascia (nephrectomy): not applicable Renal vein (nephrectomy): not applicable Ureter (nephrectomy): not applicable Adrenal gland: not submitted Lymph nodes: not submitted
+
+--- Page 2 ---
+Pathologic findings in non-neoplastic kidney:  Glomerulosclerosis - Chronic interstitial inflammation AJCc Staging: pT1b pNx This staging information is based on information available at the time of this report, and is subject to change pending clinical review and additional information. Comment: A portion of this case was reviewed in consultation with who concurs with the grade and stage of this tumor. Clinical History: -year-old male with right renal mass who presents for robotic partial right nephrectomy.. Gross Description:. Received is one appropriately labeled container, additionally labeled "right renal mass." Requisition states "stitch marks closed collecting system." It holds an 89.8 gram, 6.5 x 5.2 x 4.3 cm partial nephrectomy. The parenchymal margin is tan/brown and inked black. Within the center of the parenchyma there is a stitch marking the closed collecting system, this area is inked red. The capsule is tan/yellow, intact, bulges and is inked blue. Beneath the bulging capsule there is a 5.7 x 5.3 x 3.6 cm tan/brown firm, well circumscribed mass with areas of hemorrhage adjacent to the capsule. The mass is abutting the red inked stitched area designated by the surgeon as a closed collecting system, is 0.4 cm from the black inked parenchymal margin, and bulges but does not extend through the capsule. The uninvolved renal parenchyma is tan/brown with a distinct corticomedullary junction. A representative section of the mass is submitted to Tissue Procurement. Block summary: A1-A2 - mass with respect to red inked closed collecting system, perpendicular A3-A4 - mass with respect to black inked parenchymal margin, perpendicular
+
+--- Page 3 ---
+A5-A6 - mass with respect to capsule, perpendicular A7 - uninvolved kidney parenchyma away from mass. Tissue remains in formalin.. 2/23/13 SQUALIFIE d0113
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diff --git a/output/text/a25c8c50-5708-4156-a68b-1c390714ca60.txt b/output/text/a25c8c50-5708-4156-a68b-1c390714ca60.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5558999252cd054621fc826dcd5c1712e88d25a4
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Department of Pathology Page 1 of 3 UUID:519C82A6-289D-4DB7-B484-8FDFDA1A1B40 REPORT Tel: TCGA-VD-A8KM-01A-PR Redacted Clinical Consultant & Location Sex Unlt No Thls Copy For: LCaD-t>- SPECIMEN LEFT ENUCLEATED EYE Prognostic rmijecL 877t13 CLINICAL DETAILS Sib C ChnssL Cb9.3 Choroidal melanoma. J 1(17/14 Tumour size: 16.6 x 15.7mm (8.9mm). MACROSCOPIC DESCRIPTION An intact, left eye.. Dimensions: Axial 24.Smm, Horizontal 26mm, Vertical 26mm. Cornea: Horizontal 12mm, Vertical 12mm. Optic nerve Length 10mm, Diameter 4mm On trans-illumination, a shadow measuring 20 x 2lmm is seen posterolaterally. Plane of section: horizontal Intraocular description: On opening, a black mass is seen. The tumour extends 1.6mm from the optic nerve. Tumour size LBD 16.8mm, Height 9mm MICROSCOPY Sections show a pigmented choroidal melanoma of mixed cell type in which the epithelioid cell component amounts up to 804. Tumour cells express Melan-A and Hsp 27 (score 1). The number of mitosis is approximately 2/4o high power fields. The microvasculature of the melanoma is prominent but closed loops are not present in the planes of sections. The. lymphocytic infiltrate within the tumour is mild. Scattered macrophages are present. Tumour necrosis is not seen. Reported: Pathologist: Electronically Verified:
+
+--- Page 2 ---
+Department of Pathology Page 2 of 3 HISTOPATHOLOGY REPORT Tel: Surname Lab No Cllnical Consultant & Locatlon Forename(s)  DOB/Age  Sex M Unit No Request Date This Copy For: Bruch's membrane appears intact in the sections examined. There is minimal tumour extension into inner sclera but no evidence of optic nerve or vortex veins involvement is seen. Tumour cells are not seen at the resection margins. Elsewhere, the cornea shows no significant abnormality. The. anterior chamber angles are open and the anterior chamber is deep. The iris shows no significant abnormality but the ciliary body appears atrophic with hyalinisation of ciliary processes. The lens shows subcapsular degenerative changes. Retina overlying the tumour is slightly atrophic and there is peripheral cystoid degeneration.. DIAGNOSIS Left eye, enucleation: Choroidal melanoma of mixed cell. type. SUMMARY SPECIMEN 2= Eye TUMOUR PRESENT Yes TUMOUR TYPE 1= Melanoma CELL TYPE 3= Mixed CT LOOPS 1= No closed loops. NECROSIS  No PIGMENTATION Yes LYMPHOCYTIC INFILTRATIONS No MITOTIC FREQUENCYS 2/40 HPF DIFFUSE MELANOMA No SPREAD 2= Intra-scleral. CLEARANCE 2= Adequate HSP-27 POSITIVITY 1= 0-20% LARGE DIAMETER 16.8 mm THICKNESS 9 mm Reported: Pathologist: Electronically Verified:.
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diff --git a/output/text/a25f2fea-4e60-4c8e-be86-4b4b3db78169.txt b/output/text/a25f2fea-4e60-4c8e-be86-4b4b3db78169.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b6b2a527c1f8e5b743eaf824aa6ace1a300613f3
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Resident: Pathologi: PATHOLOGIC DIAGNOSIS: A. SPECIMEN DESIGNATED "OMENTUM, BIOPSY": Fibroadipose tissue with fat necrosis, calcifications, and hemosiderin-laden macrophages. B. SPECIMEN DESIGNATED "RIGHT ILEOCOLECTOMY" (34 Cm): MUcINOus ADENOcARCINOMA, low grade, moderately differentiated (9.3 cm in greatest dimension). Tumor is located in the cecum, forms a fungating mass, is ulcerative, and has an infiltrating border. Tumor invades through the muscularis propria. Proximal and distal resection margins are negative for tumor. Invasive tumor is 7.9 cm from proximal resection margin, 23 cm from distal resection margin, and 2.5 cm from radial resection margin. Lymphovascular invasion is not identified. Extramural venous invasion is not identified. Perineural invasion is not identified. Peritumoral lymphoid response (including Crohn?s-like infiltrate) is marked. Residual adenoma is present. Appendix with no significant pathologic change. Regional lymph nodes (positive:total): 1:18. AJCC classification (6th edition): T3 N1 MX. CLINICAL DATA: History: with colon CA and pulm. Operation: R colectomy. Operative Findings: None specified.. clinical Diagnosis: Colon CA. TISSUE SUBMITTED: A/1) Omental nodule. B/2) R hemicolectomy --> Tissue Bank. GROSS DESCRIPTION: The specimen is received fresh in two parts, labeled with the patient's name and medical record number. Part A, "#1. Omental nodule", consists of one white/tan calcified nodule (3.2 x The specimen is submitted for decalcification prior to histologic examination. Micro A1-A5: Omental nodule, 1-2 frags each, Part B, "#2. Right hemicolectomy", consists of one ileocolectomy specimen and an appendix (7.2 x 0.8 cm) with a proximal stapled resection margin (3.1 cm, inked blue) and a distal stapled resection margin (6.5 cm, inked blue). A fungating tumor with central ulceration (9.3 x 5.1 x 0.9 cm) is present in the cecum abutting the ileocecal. valve, 7.9 cm to the proximal stapled resection. margin, and 23.0 cm to the distal stapled resection margin. A focal Page: I of2
+
+--- Page 2 ---
+Pathology Report hemorrhagic lesion (2.5 x 1.8 x 0.4 cm) is present 15.0 cm distal to. the mass, 8.0 cm to the distal stapled resection margin, and 24.0 cm to the proximal stapled resection margin..  The tumor mass grossly invades into the pericolonic fat. The remainder of .the mucosa is unremarkable. Twenty one candidate lymph Representative sections of the main mass and normal colon are submitted to the tissue bank. A representative section of the mass is submitted for GI stem cell culture.  Gross photographs are taken.. Micro Bl: Proximal resection margin, 2 frags, Micro B2: Distal resection margin 1 frag, Micro B3: Tumor to normal mucosa, 1 frag, Micro B4: Tumor with deepest extent of invasion, 1 frag, Micro B5: Representative sections of t 2 frags, Micro B6: Hemorrhagic lesion, 1 frag. Micro B7: Normal mucosa,. frag Micro B8 through B9: Appendix, multi frags, 2 frags, Micro B10: Largest candidate lymph node bisected, Micro B11 through B17: Candidate lymph nodes, 3-4 frags eac CASE NUMBER: By his/her signature below, the senior physician certifies.that he/she personally conducted a microscopic examination ("gross only" exam if so stated) of the described specimen(s) and rendered or confirmed the diagnosis(es) related thereto. Final Diagnosis by Electronically signed on. Page: 2 of2
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diff --git a/output/text/a2866aec-5203-425a-bcfc-e49d326c974c.txt b/output/text/a2866aec-5203-425a-bcfc-e49d326c974c.txt
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index 0000000000000000000000000000000000000000..02b7925bb86993c604290b4413cd4ae2f9aee6ae
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:BEB0E95C-EDF2-40A5-BB95-588D07369CEE TCGA-E7-A7DU-01A-PR Redacted TSS Patient ID: Surgical Date: Gross Description: 1. Bladder tumor fragments endoscopy recovered with histologic aspect of papillary urothelial carcinoma well/moderate differentiated G1/G2 (low-grade), areas of squamous metaplasia,. ulcerated, nectrotic, stpT1 (at least).. 2. Piece of cystoprostatectomy presenting the urinary bladder with a vegetative tumoral proliferation,. developed on trigone, retro-trigone and left wall level, with intramural evolution, peri-Ous, large implanting base and invasive in the whole wall. Histopathological aspect of infiltrative urothelial cell carcinoma, well/moderately differentiated, G1/G2 (low-grade), with areas of squamous metaplasia, ulcerated, necrotic, intramural evolution and invasion of the entire bladder wall; stpT3. Prostate and seminal vesicles with histological structure preserved. 3.Right ilio-obturator group of 8 (eight) lymph nodes of maximum 1.3 cm in dimensions, with reactive aspect, congestion and sclera-lipomatous dystrophy 4. Left ilio-obturator group of 6 (six) lymph nodes of maximum 1.5 cm with reactive aspect, congestion and sclero-lipomatous dystrophy.. 5-6. left and right ureter with preserved histological aspect. Microscopic Description: Diagnosis Details: CONCLUSION: Papillary urothelial cell carcinoma of the bladder, well/moderate differentiated, G1/G2, (low-grade) with areas of squamous metaplasia, stpT3, pNo, pMx (stage III). ICD-0 3 erunmxwruthliil No S Comments: 8/2013 Formatted Path Reports: BLADDER TISSUE CHECKLIST Specimen type: Cystectomy J830/3 Tumor site: Bladder Ste Tumor size: 4 x 4 cm AtJ 9/4/13 Tumor features: Ulcerated Histologic type: Transitional cell carcinoma, papillary Histologic grade: Moderately to well differentiated
+
+--- Page 2 ---
+Tumor extent: Perivesical tissue (microscopic). Lymph nodes: 0/14 positive for metastasis (Regional 0/14) Lymphatic invasion: Not specified. Venous invasion: Not specified. Margins: Uninvolved Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None
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diff --git a/output/text/a28a1b3d-210f-488f-813f-54a5280d9d62.txt b/output/text/a28a1b3d-210f-488f-813f-54a5280d9d62.txt
new file mode 100644
index 0000000000000000000000000000000000000000..66572b07a3c163053ca4ce473d3fde50f528704f
--- /dev/null
+++ b/output/text/a28a1b3d-210f-488f-813f-54a5280d9d62.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Icd- u - > bnfiltrati`Ng duct, NU5 850v|3 Palieni hisiry: Carcn mi. The patient is a tw PRE-OP DIAGNOSIS: Left breast cancer.. POST-OP DIAGNOSIS: Same. c50.3 PROCEDURE: Left total mastectomy. . CQCF: bunst,Nvs L5D.9 ADDENDA: Addendum Fluorescence in situ hybridization analysis was performed on block 1D using the DNA probe for Her-2/neu gene. The ratio of Her-2/neu gene signals to chromosome 17 centromere signals was determined to be 2.05. Therefore, the interpretation is:  borderline amplification of the Her-2ineu gene. UUID:D24BB508-6E9A-4CF7-93C6-975E79F6E86D TCGA-BH-A18P-01A-PR Redacted My signature is attestation that ! have personally reviewed the submitted materia vove dlagnosis reflects that evaluation Addendum ESTrOGen/prOgeSterONe AND hER-2ineU REPORt Using appropriate positive and negative controls, the test for the presence of these hormone receptor proteins is. performed by the immunoperoxidase method, and reported according to the ' consensus statement on adjuvant. therapy for breast cancer, oty A positive ER or PR tumor shows any nuclear immunostaining, and is  semiquantitated as indicated below. Result Semiquantitative Statement ER positive Percent cells staining as: (0 95%; 1+ 5%, 2+ 0%, 3+ 0%)  PR negative Percent cells staining as: (0 100%, 1+ 0%, 2+ 0%, 3+ 0%) HER-2/NeU DAKO hERCEPTEST: A WEAK TO MODERATE COMPLETE mEMBRANE STAInInG IS OBSERVED IN mORE tuan 10% OF THE TUMOR CELLS. hER-2/NEU iS iNTERPRETEO AS WEAKLY POSITIVE ISCORE 2+l. NOTE: Her-2/Neu FISH was ordered and will be subsequently reported. The Her-2/neu and estrogen/progesterone receptor assays were performed with FDA approved methods. FINAL DIAGNOSIS: Part 1: teft Breast, total. mastectomy - A.-tNFILTRATiNG DUCTAL CARCINOMA, 2.0 CM, nOTTiNGhAm SCORE 7/9 (tubules 3, nuclei 2, mitosis 2), TOcaTed in tHe LoWeR inner qUaDrANt And exTenDInG tO the Lower Outer quaDrant. TUmOR COMES TO WITHIN O.1 CM FROM THe inNER LOWER Of QUADRAnT MARGIN. C.  MICROCALCIFICATION ASSOCIATED WITH TUMOR. D. DUCTAL CARCInOMA IN SITU, nUCLEAR GRADE 2, SOLID TYPE WITH COMEDO NECROSIS, REPRESENTING 10-15% Of THE TUMOR VOLUmE. E. MARGINS FREE OF TUMOR. F.  REMAINING BREAST TISSUE WITH FIBROCYSTIC CHANGES, SCLEROSiNG ADENOSIS AND MICROCALCIFICATION. G. SKIN AND NIPPLE NOT REMARKABLE. H.  Three lymph nodes negative for tumor. PaRt 2: LEft AXILLA, SenTinel Lymph nOde #1, EXcISiOnal BIOpsy -  One Lymph nOde negaTIve fOr TumOR, COnfIRmed by negativE AE1/ae3 immunOstain. PArt 3: Left AXIlLA, Sentinel Lymph nODe #2, EXcisiOnal BIOpsy : ONe LyMPH NODe NEGATIVE fOR TUMOR, CONFIRMED BY NEGATIVE AE1/AE3 immUNOSTAIN. COMMENT: Estrogen and Progesterone receptors and HER-2/Neu will be performed on block 1D and the result will follow in a. separate report.
+
+--- Page 2 ---
+MICROSCOPIC: SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST A. Laterality: 2 1. Right 2. Left B. Procedure: 2 1. Segmentectomy 3. Modified radical mastectomy 2. Simple mastectomy 4. Re-excision C. Location: 4. 5 1. Central subareolar 4.L0Q 2. u0Q 5. LIQ 3. UIQ 6. Not specified D. Size of tumor (maximum dimension invasive component by gross or microscopic exam): 2.0 cm E. Type (invasive component): 1 1. Ductal, NOS 5. Cribriform 9. Metaplastic 2. Tubular 6. Papillary 10. Other 3. Mucinous 7. Lobular 4. Medullary 8. Carcinoid like F. If lopular carcinoma, specify type:# 1. Classical 4. Signet ring 7. Pleomorphic 2. Solid 5. Trabecular  3. Alveolar 6. Tubulobuiar G. Nottingham Score: G1. Nuclear grade: 2 G2. Tubule formation: 3. G3. Mitotic activity score: 2 G4. Total Nottingham score: 7 G5. Nottingham grade (1, 2, 3): 2 H. Angiolymphatic invasion: 1 1.No 2. Yes 1. Dermal lymphatic invasion: 2 1. Yes 2. NO 3. Not applicable J. Calcification:  2.3 1. No 2. Yes- benign zones 3. Yes -- malignant zones K. Type of in situ component: 2.6 1. Cribriform 4. Micropapillary 7. Lobular 2. Solid 5. Apocrine 3. Papillary 6. Comedo Percentage of tumor occupied by in situ component: 10-15% M. Surgical margins involved by invasive component: 1. No 2. Yes-focal 3. Yes -- diffuse N. Surgical margins involved by in situ component: 1.No 2. Yes -- focal 3. Yes - diffuse O. Paget's disease of nipple: 2 1.Yes 2. No Q. Total number of lymph nodes examined:  5 R. Sentinel node metastasis: 2 1. Yes 2. No S. Only micrometastases to lymph nodes (none larger than 0.2 cm): 2. 1.Yes 2. No T. Metastasis/es to a lymph node 2 cm. or more in greatest dimension: 2. 1. Yes 2. No U. Lymph node metastasis/es with extracapsular extension: 2 1. Yes 2. No V. Metastases to ipsilateral intemal mammary lymph node (if applicabie): 2. 1. Yes 2. No W. Skin involved (ulceration): 2 1. Yes 2. No X. Non-neoplastic breast tissue: 6/#/#1# 1. ADH 4. Fibroadenoma 7. LCIS 2. ALH 5. Papilloma 8. Other 3. Radical scar 6. FCD Y. Multicentricity/rnultifocality of invasive foci: 2 1. Yes 2. No Y1: Sizes of invaxive foci: # cm / # cm /# cm Y2: Aggregate diameter of Y1 tumors: # cm Z. TNM stage: 'Ticngmx.
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diff --git a/output/text/a2ab247f-228a-429f-b70b-27fc74f70273.txt b/output/text/a2ab247f-228a-429f-b70b-27fc74f70273.txt
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index 0000000000000000000000000000000000000000..3ee3010532f20538666d9f1b1d6b50f5ff1f869e
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+--- Page 1 ---
+Iis. lnyu1t^uhx; iluct Cnurmu,Nvs 35ct|3 hw nffe Site. brt, Nvs e50.9 page 1 / 1  Department of Cancer Pathologye copy No. Date: Examination: Histopathological examination Examination No.: Patient. PESEL: Age: Gender: F Material: Multiple organ resection - right breast Unit in charge: Physician in charge: Material collected on: Material received on: Expected time of examination: up to. Clinical diagnosis:  Examination performed on: Macroscopic description:  Right breast, sized 25.3 x 18.2 x 5.3 cm, removed along with axillary tissues sized 5 x 7 x 3 cm and a skin flap of 24.7 x 11.6 cm. Weight 1,100 g. Tumour sized 3.2 x 1 x 1.4 cm in the upper outer quadrant, placed 3 cm from the upper edge, 0.8 cm from the base and 1.9 cm from the skin.. Microscopic description: Carcinoma ductale invasivum - NHG1 (2 + 2+1:2 mitoses/ 10 HPF, visual area diameter 0.55 mm). Numerous focuses of carcinoma ductale in situ (Dcis) found within tumour (solid and cribrate type, with medium  nuclear atypia, comedo necrosis and calcifications, 15% of the tumour). Mamilla sine laesionibus.. Glandular tissue showing lesions of the type mastopathia fibrosa. AXILLARY LYMPH NODES: Lymphonodulitis chronica et sinus histiocytosis lymphonodorum (No XI). Examination result: Carcinoma ductale invasivum et ductale in situ mammae dextrae. (NHG1, pT2, pN0). Compliance validated by:  Examination performed on  Results of immunohistochemical examination: Estrogen receptors found in 75% of neoplastic cell nuclei. Progesterone receptors found in 75% of neoplastic cell nuclei. HER2 protein stained with HercepTest'" by DAKO. Negative reaction in invasive carcinoma cells ( Score = 1+ ). Compliance validated by: UUID:79749F5D-329A-400D-8511-C4CF479C1FCC tCGA-D8-A146-01A-PR riteria Redacted
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+1cD-0-3 Carcinoms, infiltrstmug oluctl, Nrs 850o/z Pai Sit, hust, uos c50.4 1/as CqCF Sth: busst,N93 C50.9 Diagnosis: Poorly differentiated invasive ductal carcinoma.(tumor diameter. 2.5 cm) with discrete intraductal components. No skin infiltration. Considering the tumor-free medial follow-up resection material (sample 3), the carcinoma was certainly excised in toto. Concluding tumor classification: NOS, G IlI, pT2N0LOV0R0 (6th edition, 2003). UUID: DD669244-34D8-4725-A52C-F3AAF59852F9 CGA-A
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diff --git a/output/text/a2f0a1c5-db0c-48fe-857e-6652b5cfa447.txt b/output/text/a2f0a1c5-db0c-48fe-857e-6652b5cfa447.txt
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index 0000000000000000000000000000000000000000..8bd2bd9558fa28079878436e5b47318060081293
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+zcDo-3 Carc nore, adrera! co tcal UUID:A1C555F3-4513-45C6-9A39-968902130894 83703 CGA-OR-A5LR-01A-PR Redacted Site C Ad^enalGlawd Cortex C 74 Yq/s/13 Procedure: Left adrenalectomy Gross description: tumor is 96g; measuring 6.7 x 4.6cm. Diagnosis: Adrenal cortical carcinoma. Weiss score = 7.
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diff --git a/output/text/a33da3c6-d7d3-456b-b8b3-a9a001830c09.txt b/output/text/a33da3c6-d7d3-456b-b8b3-a9a001830c09.txt
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+1cp-0-3 Path Sit. brst uoq c50.4 CQcF Site: Bresot, Nos c5o.9 Diagnosis: 1. Right-sided ablated breast tissue multicentric, poorly differentiated, invasive ductal breast. carcinoma with at least four foci measuring a maximum diameter of 2 cm, 3 cm, 0.7cm and 2.5 cm, partly with inclusion of a high-grade intraductal carcinoma with comedo necroses in. the tumor periphery and surrounded by a mastopathy with partially sclerotic, intraductal,. papillomatous scleradenosis with microcalcifications and also cystic mastopathy and cylindrical epithelial metaplasia. The overlying skin and nipple are tumor-free, no pagetoid pattern of spread. the outer resection margins are tumor-free.. Tumor classification: M-8500/3, G 3, pT2 (m), pN1a (2/25), pMX, stage II B. R0. UUID:A314FB55-F20A-4485-965D-D7894D070A16 TCGA-A8-A06U-01A-PR Redacted
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diff --git a/output/text/a35a09a8-05b3-4077-b108-33c61caab5e3.txt b/output/text/a35a09a8-05b3-4077-b108-33c61caab5e3.txt
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+1Cs-0-3 Carcinoma,infiltratny 1rsulxv,Nos 852o13 Site: brewt, Nos. C50.9 y2fn pu Specimen: Received: Status: Req#: Spec Type: SURGICAL P Subm Dr: HAGNOSIS RIGHT BREAST CANCER - IN SITU, LEFT FIBROCYSTIC BREAST CANCER OPEPATTO! TEFRMED DATE: DOCTOR(S) : PROCEDURE: BILATERAL SIMPLE MASTECTOMY-SENTINEL NODE BXS .. RT BREAST MASTECTOMY LT I BREAST MASTECTOMY UUID:58685F7F-917D-41BA-A7AB-D0E15D4578C5 Redacted RT AXILLA SENTINEL NODE #1 TCGA-A2-A0T4-01A-PR D. RT  AXILLA NON SENTINEL NODE E. LT AXILLA SENTINEL NODE #1 F. LT AXILLA SENTINEL NODE #2 PART A  RECEIVED FRESH LABELED. RIGHT BREAST INK MARKS TUMOR STITCH 12 O'CLOCK, IS A SIMPLE MASTECTOMY SPECIMEN WITH OVERALL DIMENSIONS OF 24.5 X 21 X 3.5 CM. THE NIPPLE IS UNREMARKABLE WITHIN A 6 X 3-CM ELLIPSE OF SKIN. A SUTURE DENOTES 12 O'CLOCK.  ADJACENT TO THIS SUTURE IN THE UPPER INNER QUADRANT IS BLACK INK DENOTING THE TUMOR AREA. THIS AREA IS OVERMARKED WITH RED INK. THE SUPERFICIAL ASPECT OF THE SPECIMEN IS MARKED IN BLUE, THE DEEP IN BLACK INK. IN THE UPPER INNER QUADRANT, THERE IS A FIRM PALPABLE MASS MEASURING 2.3 X 3.3 X 1.7 CM. THIS IS O.6 CM FROM THE DEEP MARGIN. A RIBBON CLIP IS IDENTIFIED WITHIN THIS MASS. A PORTION OF THIS IS SUBMITTED PER PROTOCOL.S THE BREAST TISSUE CONSISTS OF A MIXTURE OF BLAND YELLOW FATTY TISSUE AND PINK-TAN FIBROUS TISSUE WHICH PRIMARILY IS CENTRAL AND COMPRISES NO MORE THAN 20% OF THE PARENCHYMA. THIS MASS IS 1.5 CM FROM THE SUPERFICIAL MARGIN. ADDITIONALLY WITHIN THE CONTAINER ARE TWO IRREGULAR PORTIONS OF YELLOW FATTY TISSUE MEASURING 8.5 X 8.3 X 1.5 CM TOGETHER. THIS TISSUE IS GROSSLY UNREMARKABLE AND NO SECTIONS ARE SUBMITTED. SECTIONS ARE SUBMITTED AS FOLLOWS: A1--NIPPLE AND ADJACENT SKIN (MIRROR IMAGE TO PROTOCOL), A2--SUPERIOR PORTION OF LESION TO INCLUDE DEEP MARGIN (MIRROR IMAGE TO PROTOCOL), A3--THE REMAINDER OF THE FULL CROSS-SECTION TO A2 TO INCLUDE THE INFERIOR ASPECT OF THE LESION, A4--SECTION OF TISSUE IN AREA OF RIBBON CLIP (MIRROR IMAGE TO TUMOR BLOCK), A5--TISSUE TAKEN FROM UPPER OUTER QUADRANT 6 CM FROM THE LESION (MIRROR IMAGE TO PROTOCOL). A6--MEDIAL ASPECT OF LESION TO INCLUDE DEEP MARGIN, A7--TISSUE IMMEDIATELY LATERAL TO A6 NOT GROSSLY TUMOR, A8--REPRESENTATIVE LOWER OUTER QUADRANT, A9--REPRESENTATIVE LOWER INNER QUADRANT. A1O--ADDITIONAL SECTION OF DEEP MARGIN. A11--TUMOR ADJACENT TO DEEP MARGIN WITHOUT INKED MARGIN PRESENT IN THE SECTION. PART B RECEIVED FRESH LABELED LEFT BREAST STITCH AT 12 O'CLOCK, IS A SIMPLE MASTECTOMY SPECIMEN MEASURING 22 X 18.5 X 3.3 CM.
+
+--- Page 2 ---
+(Continued) Specimen: ( ) Received: Status: Req#: Spec Type: SURGICAL P Subm Dr: (Continued) THE NIPPLE IS UNREMARKABLE WITHIN A 6.3 X 3.9-CM SKIN ELLIPSE. A SUTURE DENOTES 12 O'CLOCK. THE SUPERFICIAL ASPECT IS MARKED WITH BLUE INK, THE DEEP MARGIN WITH BLACK INK. SECTIONING REVEALS CENTRAL GRAY FIBROTIC TISSUE INTERMINGLED WITH YELLOW FATTY TISSUE WITH A PERIMETER OF BLAND YELLOW FATTY TISSUE WITH FINE FIBROUS BANDS. THE FIBROUS TISSUE COMPRISES 2O% OF THE SPECIMEN.  SECTIONS ARE SUBMITTED AS FOLLOWS: B1--NIPPLE, B2--UPPER INNER QUADRANT. (MIRROR IMAGE TO PROTOCOL). B3--UPPER INNER QUADRANT, B4 AND 5--LOWER INNER QUADRANT, B6 AND 7--LOWER OUTER QUADRANT, B8 AND 9--UPPER OUTER QUADRANT, B1O--CENTRAL WITH DEEP MARGIN. PART C RECEIVED FRESH LABELED RIGHT AXILLA FIRST SENTINEL NODE HOT, IS AN OVOID PORTION OF YELLOW FATTY TISSUE MEASURING 3 X 2.2 X 1.2 CM. SECTIONING REVEALS A 1.2-CM GROSSLY FAT-REPLACED LYMPH NODE, SUBMITTED ENTIRELY LABELED C1. A SECOND 1-CM GROSSLY FAT-REPLACED LYMPH NODE IS IDENTIFIED. THIS IS SUBMITTED LABELED C2. PART D RECEIVED FRESH LABELED RIGHT AXILLA NONSENTINEL NODE, IS AN OVOID PORTION OF YELLOW FATTY TISSUE MEASURING 3 X 1.8 X 1.0 CM. SECTIONING REVEALS A 1.5-CM GROSSLY FAT-REPLACED LYMPH NODE, SUBMITTED LABELED D. PART E RECEIVED FRESH LABELED LEFT AXILLA FIRST SENTINEL NODE HOT, IS AN OVOID PORTION OF YELLOW FATTY TISSUE MEASURING 3.5 X 1.5 X 1.5 CM. SECTIONING REVEALS A 4-CM GROSSLY FAT-REPLACED LYMPH NODE, ENTIRELY SUBMITTED AS E1 AND 2. PART F RECEIVED FRESH LABELED LEFT AXILLA SECOND SENTINEL NODE, IS YELLOW FATTY TISSUE MEASURING 3.5 X 3.2 X 1.5 CM. EXAMINATION REVEALS A 1.2-CM IN GREATEST DIMENSION CENTRALLY FAT-REPLACED LYMPH NODE, SUBMITTED LABELED F. ONE ADDITIONAL 0.5-CM LYMPH NODE IS SUBMITTED ALSO LABELED F. PROCEDURES: 88305, 88307/5, IMMUNOPEROXIDAS/3, A BLK/11, B BLK/10, CBX X6/2, D BLK, EBX X6/2, FBX X6 Cat inccis. (R1cC 01.2 -3 PHHAL DIAGHOSS (R) Lcis PART A RIGHT SIMPLE MASTECTOMY: IN SITU AND INFILTRATING LOBULAR THE TUMOR SPANS A MICROSCOPIC DISTANCE OF 3.3 CM IN THE UPPER INNER QUADRANT OF THE BREAST.  THE TUMOR DOES HAVE A MICROSCOPIC MULTIFOCAL 3.3c m QUADRANTS OF THE BREAST DO NOT SHOW EVIDENCE OF MALIGNANCY. THE DEEP MARGIN IS FREE OF TUMOR BY A DISTANCE OF 5 MM.
+
+--- Page 3 ---
+(Continued) Specimen: Received: Status: Rea#: Spec Type: SURGICAL P Subm Dr: (Continued) PART B LEFT SIMPLE MASTECTOMY: DIFFUSE PROLIFERATIVE FIBROCYSTIC CHANGES WITH AREAS OF ATYPICAL DUCT AND LOBULAR HYPERPLASIA AND EXTENSIVE ADH ALF MICROCALCIFICATION. NO EVIDENCE OF INVASIVE CARCINOMA. Ca+ in i39 PART C RIGHT AXILLARY SENTINEL LYMPH NODE #1, BIOPSY: LYMPH NODE WITH NO EVIDENCE OF METASTATIC DISEASE, SUPPORTED BY NEGATIVE CYTOKERATIN/ IMMUNOHISTOCHEMICAL STAINING. PART D RIGHT AXILLARY NONSENTINEL LYMPH NODE, BIOPSY: LYMPH NODE WITI NO EVIDENCE OF METASTATIC DISEASE. PARTS E AND F LEFT AXILLARY SENTINEL LYMPH NODES NUMBERS 1 AND 2, BIOPSIES: LYMPH NODES WITH NO EVIDENCE OF METASTATIC DISEASE, SUPPORTI BY NEGATIVE CYTOKERATIN IMMUNOHISTOCHEMISTRY. Signed (prelim.) (signature on file)
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+FINAL DIAGNOSIS B. TUmOR iS COnFiNEd TO THe KIDnEy ParENCHyMA...  NO angiolymphatic invasion seen.  C. D. GLOMERULOSCLEROSIS: :  SUrgical REsection mArgins Are Free OF NeopLASM 1 Tnm stage: t1nxmx. G. hIStOpaTHOlOgICal GraDE:G2
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diff --git a/output/text/a39f8095-6d89-404e-9f69-ba28fc2b20d1.txt b/output/text/a39f8095-6d89-404e-9f69-ba28fc2b20d1.txt
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+1cs-0-_3 Carciomnn, ui fil+^ntrg 1obuls Nrs 85x0/3 Sitr: brst Nos' c50.9 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 Y SURGICAL PATHOLOGY REPORT Patient: BAss Specimen #: FMP/SSN: DOb/Age/Sex: Race: WHITE Taken: Location: Received: Physician(s) : Reported: SPECIMEN: A: LEFT BREAST LUMPECTOMY B: SENTINEL NODE #1 C: ADDITIONAL SUPERIOR MARGINS D: ADDITIONAL DEEP MARGIN FINAL DIAGNOSIS: A. BREAST, LEFT, LUMPECTOMY: - TUMOR TYPE: INFILTRATING LOBULAR CARCINOMA, SEE COMMENT. NOTTINGHAM GRADE: II (MODERATELY DIFFERENTIATED). NOTTINGHAM SCORE: 6 OF 9 (Tubules= 3, Nuclei= 2, Mitoses= 1). TUMOR SIZE (GREATEST DIMENSION): 2.3 CM, SEE COMMENT. TUMOR NECROSIS: NOT IDENTIFIED.  MICROCALCIFICATIONS: PRESENT.  VENOUS / LYMPHATIC INVASION: NO DEFINITIVE EVIDENCE. PERINEURAL INVASION: PRESENT (A5, A13).  MARGINS :  PRESENT AT LATERAL MARGIN (A3) AND POSTERIOR MARGIN (A1O)  TUMOR MEASURES O.3 CM FROM CLOSEST SUPERIOR MARGIN (A8) AND 0.3 CM FROM CLOSEST INFERIOR MARGIN (A16) INTRADUCTAL COMPONENT: LOBULAR CARCINOMA IN SITU PRESENT. LYMPH NODES: INDIVIDUAL TUMOR CELLS IDENTIFIED (SEE PART "B") SKIN INVOLVEMENT: NOT IDENTIFIED. MULTICENTRICITY: NOT IDENTIFIED. ESTROGEN RECEPTORS: POSITIVE (SEE PROGESTERONE RECEPTORS: POSITIVE (SEE HER 2 NEU by IHC: NEGATIVE (1+) (SEE PATHOLOGIC STAGE: pT2 NO(i+) Mx (AJCC, 6th edition). ADDITIONAL PATHOLOGIC CHANGES: FIBROCYSTIC CHANGES TO INCLUDE USUAL DUCT HYPERPLASIA, APOCRINE METAPLASIA, STROMAL FIBROSIS, AND MICROCYSTS COLUMNAR CELL CHANGE WITHOUT ATYPIA PREVIOUS BIOPSY SITE CHANGE WITH SURGICAL MARKER IDENTIFIED  UNREMARKABLE SKIN B. LYMPH NODE, SENTINEL #1, I EXCISION: RARE INDIVIDUAL TUMOR CELLS FOUND ON CYTOKERATIN IMMUNOHISTOCHEMISTRY. BREAST, LEFT (ADDITIONAL SUPERIOR MARGIN), EXCISION: UUID:5882545F-2636-4A8A-88DD-18387DE678FF TCGA-A2-A0EX-01A-PR Page 1 Redacted Continued on Next Page  NLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 2 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974S ? SURGICAL PATHOLOGY REPORT Patient: Specimen #: FINAL DIAGNOSIS (continued): TUMOR PRESENT <O.1 CM (O.9 MM) FROM THE DESIGNATED "NEW TRUE MARGIN" (C8), SEE COMMENT. D. BREAST, LEFT (ADDITIONAL DEEP MARGIN), EXCISION:) - BENIGN BREAST TISSUE - NEGATIVE FOR MALIGNANCY. COMMENT : PART A. The tumor exhibits a lobular growth pattern, which is confirmed by an E-cadherin immunohistochemicai stain. However, focal tubular formation is noted in scattered portions of tumor. Based on morphologic and immunohistochemical features, the tumor type is interpreted as being infiltrative lobular carcinoma with focal ductal differentiation. Assessment of the greatest dimension of tumor size is hindered by the multifocal nature of the infiltrating lobular carcinoma. The greatest dimension of 2.3 cm is based on the combination of microscopic and. radiographic findings in this case. PART C. The tumor exhibits features that are similar to those features seen in the tumor in Part A. This case received intradepartmental consultation.. Previous biopsy material was reviewed in conjunction with this. case. ** Report Electronically Signed Out **. CLINICAL DIAGNOSIS AND HISTORY: y/o female with history of left breast mass PRE-OPERATIVE DIAGNOSIS: none provided Page 2 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 3 ---
+TOR OFFICIAL USE ONLY - PERSOWAL DATA - PRIVACY ACT OF 1974 1 SURGICAL PATHOLOGY REPORT Patient: Specimen #: POST-OPERATIVE DIAGNOSIS: none provided GROSS DESCRIPTION: A: Received fresh, labeled with the patient's name designated "Left Breast Lumpectomy" is a breast lumpectomy specimen with and accompanying radiograph, measuring 6.0 cm from superior to inferior, 3.5 cm from medial to lateral, and 2.0 cm from anterior to posterior. A 4.0 x 0.6 cm lightly pigmented, loosely adherent skin ellipse is noted on the superficial surface. The specimen is inked as follows: superior - blue; inferior - green; medial - red; lateral - yellow; anterior .  orange; posterior - black. Serial sectioning reveals a 1.5 x 1.0 x 0.6 cm poorly defined mass. The cut surface is tan-white, firm and focally congested with an embedded metallic clip. The mass is located 0.5 cm from the anterior, medial, and posterior margins, and 0.7 cm from the lateral margin. The remainder of the specimen is composed of markedly dense tan-white fibrous tissue admixed with a minimal amount of adipose tissue. Entirely submitted. Cassette Summary: Al-anterior-lateral margin with skin A2-posterior-medial margin A3-posterior-lateral margin A4-posterior margin A5-mass A6-mass in relation to deep margin A7 through A16 - remaining serial sections from superior to inferior, with matched plane sections in A10-A11 and A12-A13. B: Received fresh, labeled with the patient's name. designated "Sentinel Node #1" is a single 2.0 x 1.5 x 0.7 cm pink-tan and lymph node. The specimen is trisected and submitted in cassettes B1-B2. . A matched section of B1 is submitted in for cbcp protocol. C: Rereived in formalin, labeled with the patient's name, and designated "Additional Superior Margin" is an irregular. fragment of pale yellow adipose tissue measuring 5.2 x 2.9 x 1.0 cm in overall dimensions. Several metallic staples are present embedded on one surface of the specimen; this surface is designated as the new true. margin. This surface will be inked orange and the opposing surface will be inked blue. The specimen is serially sectioned to reveal a dense tan-white fibrous cut surface. Residual tumor is not grossly identified. The specimen is entirely and sequentially submitted in eight cassettes. 8cfns D: Received in formalin, labeled with the patient's name, Page 3 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 4 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DEsCRIPTION (continued) : and designated "Additional Deep Margin" is an irregular fragment or tan-yellow lobulated adipose tissue measuring 2.3 x 1.2 x 0.6 cm in. overall dimensions. Several metallic staples are identified embedded in one surface of the specimen; this surface is identified as the true new margin. This surface is inked orange, and the opposing surface is inked. blue. The specimen is serially sectioned to reveal a homogeneous tan-yellow cut surface without evidence of residual tumor.  The specimen is entirely and sequentially submitted in three cassettes.. Page 4 End of Report FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
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diff --git a/output/text/a3a0ab49-22fe-4166-be6b-9b497e49941b.txt b/output/text/a3a0ab49-22fe-4166-be6b-9b497e49941b.txt
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+UUID:4AF67A51-97C1-4D58-9E60-03FDFFACD38A TCGA-A7-A3RF-01A-PR Redacted 1cD o-3 carcinomg,mucinou S 84803 Sik: bregst,Nos Final Surgical Pathology Report. cSO,9 3|q1z eD Procedure: Diagnosis A.  Left axillary sentinel nodes, excision: 2 lymph nodes negative for metastatic disease, 0/2 B. Left breast mass, excision: Invasive mucinous carcinoma, Elston SBR. grade 2. Tumor is less than 1 mm from the deep margin and at least. extremely close to the lateral margin. C:  Pectoralis fascia, excision: Adipose tissue and skeletal muscle present.  Mucinous carcinoma present in the adipose tissue at the inked medial margin of resection. Microscopic Description: A. 2 sentinel nodes are present examined in their entirety at multiple levels. They are both negative for metastatic disease, 0/2 B.  This excision discloses invasive mucinous adenocarcinoma.. Of note, particularly in block #5, there was a suspicion for lymphatic invasion.. This is considered not to be the case, however,  based on stains for D240 and CD34. The negative staining for p63 also helps to exclude in situ tumor.  Please see the template below: Invasive Carcinoma: Histologic type: Invasive mucinous carcinoma. Histologic grade: Elston SBR grade 2 Overall grade: Architectural score: 2 Nuclear score: 3 Mitotic score: 1 Greatest dimension (pT): 3.7 cm, pT 2 Specimen margins: Tumor is present less than 1 mm from the deep margin and at least extremely close to the lateral margin. Vessel invasion: Negative Calcification: Rare Description of non-tumorous breast: No significant pathology Comments: Attached skin negative for tumor. Prognostic markers: Previously performed C. Microscopic examination performed Specimen  Left axillary sentinel node A. B.  Left breast mass, long anterior, short superior C. Pectoralis/posterior, long anterior short superior. Clinical Information PRE-OP DIAGNOSIS: Left breast cancer HISTORY: -year-old white female with left mucinous breast cancer
+
+--- Page 2 ---
+Gross Description A.  Received fresh labeled "left axillary sentinel node" are 2 soft tan gold-pink tissues averaging 1.8 cm in greatest dimension. The specimens are bisected and entirely submitted independently in 2 blocks. B. Received fresh for tissue procurement within a. container labeled "left breast mass" is a 7.5 cm (medial to lateral) by 5.0 cm (superior to inferior) by 4.2 cm (anterior to posterior) soft, lobulated tan gold-white portion of fibroadipose tissue with 2 sutures as stated previously. A 2.7 x 1.3 cm wrinkled tan-white portion of skin is present along the anterior aspect..  The margins are inked as follows: Anterior blue, posterior black, superior green, and inferior Orange. The specimen is sectioned from medial to lateral.. There is a well-circumscribed, 3.7 cm (medial to lateral) by 3.2 cm (superior to inferior) by 2.7 cm (anterior to posterior) rubbery tan white mucinous tumor mass within the lateral half of the specimen..  A portion of tumor and a portion of normal parenchyma are submitted for tissue procurement as requested. The tumor focally extends to within less than 0.l cm of the inked posterior margin. Several cylindrical tan-white structures in keeping with those associated with needle core biopsy are present The remaining cut surfaces consist predominantly of soft, lobulated tan gold adipose tissue with a scant amount of interspersed delicate .n-white fibrous tissue. Sumuary: 1 - perpendicular sections medial margin, 2 through 9 - sequential sections, 10 - perpendicular sections lateral margin Specimen is fixed at C.  Received fresh labeled "pectoralis fascia posterior" is a 3.0 cm (superior to inferior) by 2.5 cm (medial to lateral) by 0.7 cm anterior to posterior) soft, lobulated tan gold-white portion of fibroadipose tissue with 2 sutures as stated previously. The margins are inked as follows: Anterior blue, posterior black, medial green, and lateral Orange. The specimen is sectioned from superior to inferior. The cut surfaces consist predominantly of soft, lobulated tan gold adipose tissue with a scant amount of interspersed delicate tan-white fibrous tissue.  No residual mass lesion or abnormality is identified grossly. Summary: 1 - perpendicular sections superior margin, 2 through 4 sequential sections, 5 - perpendicular sections inferior margin Specimen is fixed at
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+
+--- Page 1 ---
+Surgical Pathology Report Name: Case #: DOb: Collected: Gender: Received: MrN: Reported: Locatlon: Copy To: Physiclan: Pathologic Interpretation:. A. Right breast 1 short stitch superior, 1 long stitch lateral: -Fibrocystic changes including consisting of apocrine metaplasia, stromal fibrosis and microcysts. B. Right axillary node: Jcs-0-3 -Two lymph nodes, no carcinoma seen (0/2) Cannomn njiltrating outl indmfi^ors 8573fj c. Left rotter lymph node: Sitei bust N1s c5u.9 3/z/ -Metastatic carcinoma to one lymph node,6.0 cm, (1/1). -Perinodal tumoral invasion seen. D. Left,breast and axilla (fresh) 1 short suture superior; 1 long suture lateral: -Inyasive, multifocal moderately differentiated ductal carcinoma with mucinous (colloid) morphology, 2.0 and 2.4 cm (sum: 4.4 cm). -No carcinoma seen in eighteen lymph nodes, (0/18). -Intraductal papilloma. -Intradermal nevus. (See tumor summary) UUID:F9F800C3-9F86-40AC-A5E8-08712CD50028 Redacted TCGA-EW-A1P0-01A-PR Tumor Summary Specimen Type: Mastectomy Lymph Node Sampling: Axillary dissection Specimen Size Greatest dimension 21.0 cm Additional dimension: 21.0 x 6.0 cm Laterality: Left Tumor Site: Upper outer quadrant Size of invasive component: Greatest dimension: 2.0 cm and 2.4 cm (sum: 4.4 cm). Histologic type: Invasive ductal carcinoma with mucinous differentiation Histologic Grade: Nottingham Histologic Score: 2 (2+2+2=6) Tubule formation: (2) Nuclear Pleomorphism: (2). Mitotic Count: (2). Pathologic staging (pTNM) Primary tumor: pT2  Regional Lymph Nodes: pN1a Number examined: 21 Number involved: 1 Distant Metastasis: pMX Margins: Uninvolved by invasive carcinoma, 1.5 cm from the superior margin Venous/Lymphatic Invasion: Absent ER: Positive (in-house Immunoperoxidase performed) PR: Negative (In-house Immunoperoxidase performed) Her2: Negative (In-house Immunoperoxidase performed) * Note: This neoplasm demonstrates a more defined mucinous differentiation on the 2.4 cm nodule, however focal mucinous differentiation is also seen on the 2.0 cm neoplasm AJCC pathologic staging pT2 N1a Mx ***Electronically Signed Out By** NOTE: Some immunohistochemical antibocies ar analyte specinic roegents (ASRs) yalidaied by our iabontory (Her ?. Paro, H. pyloni, HBcore). Thes ASRs are chinicaty usptul indicators that do Ical stains are used
+
+--- Page 2 ---
+SURGICAL PATHOL Report As the attending pathologist, I attest thet i: (i) Examnod the relevant preparation(s) for the specimen(s): and (i) Rendered the diagnosis(es). Procedures/Addenda Date Ordered: Status: Signed Out Addendum Date Complete:d Date Reported: Addendum Diagnosis D. Left breast and axilla (fresh) 1 short suture superior; 1 long suture lateral:. by immunohistochemistry. -The cells of intradermal nevus are positive fo , PhD Clinical History:. Patient is a -- I white female with history of left breast cancer. Pre Operative Diagnosis: Right breast cancer. Specimen(s) Received: A: Right breast 1 short stitch superior, 1 long stitch lateral (fresh). B: Right axillary node (perm) C: Left rotter lymph node (perm) D: Left breast and axilla (fresh) 1 short suture superior; 1 long suture lateral Gross Description: A. Received fresh and labeled *right breast 1 short stitch superior, 1 long stitch lateral" specimen consist of right breast oriented with 1 short stitch superior resection margin and 1 long stitch in lateral resection margin, 18.0 x 15|0 x 5.0 cm and weighs 775.0 grams. The skin mesures 13.0 x 8.0 cm, nipple measures 1.2 cm and the areola, 4.0 cm in citcumference. Sections reveal abundant grossly unremarkable fibroadipose tissue. The central area reveal white-tan, fibrdcystic area, 2.0 cm in greatest dimension. No tumor or any other lesions are grossly identified. Representative sectionslare submitted in ten cassettes as follows: Perpendicular representative sections from superior resection margins 2  Perpendicular representative sections from inferior resection margins. 3 Perpendicular representative sections from medial resection margins. +  Perpendicular representative sections from lateral resection margins. 5 Representative sections from nipple 6 Perpendicular representative sections from deep resection margins. 7-10 The lesion described submitted in toto (fibrocystic areas) 11 Representative from upper outer quadrant 12 Representative sections from lower outer quadrant 13 Representative sections from upper inner quadrant 14  Representative sections from lower inner quadrant B. Received in formalin and labeled 'right axillary node" specimen consist of yellow-tan, fibroadipose tisseu, 3.0 x 1.5 x 1.0 cm. Section reveal two lymph nodes. The lymph nodes submitted in toto in one cassette bissected each.. Page 2 of 3
+
+--- Page 3 ---
+SURGICAL PATHOL Report C. Received in formalin and labeled "left rotter lymph node" specimen consist of one lymph node, 6.0 x 5.0 3.0 cm and weighs 35.0 grams. Sections reveals pink-tan, well defined multinodular . No calcified or hemorrhagic areas are grossly identitified. Representative sections are submitted in eight cassettes: D.  Received fresh and labeled *left breast and axilla 1 short suture superior; 1 long suture laterat" is a masteqtomy specimen with axillary contents, weighing 1150.0 grams and measuring 21.0 x 21.0 x 6.0 cm and the axillary contents, 14.0 x 12.0 x 2.0 cm. There is an anterior ellipse of white skin, 20.0 x 10.0 cm. Located centrally within this ellipse of skin there is a nipple areola complex 3.5 cm in circumference and 1.0 cm in circumference. Located toward the outer quadrant there are two verrucose shaped hyperkeratosis lesions, 0.7 x 0.5 cm in greatest dimension. The remainder of the skin surface is unremarkable. The rest of the specimen is covered by yellow-tan lobulated adipose tissue. The surgical resection margins are inked din black. Multiple cross sections reveals an ill circumscribed gray-tan, hard greatly ma$s, 2.0 cm in greatest dimension. The mass is located in the outer quadrant approximately 1.00 o'clock position, 1.5 cm|from the superior resection margin (nearest margin) and 2.5 cm from deep resection margin. Located in the same quadrant 2.5 cm from the mass previously described there is a second ill circumscribed gray-tan, hard nodule measuring 2.4 cm in greatest dimension, this mass is 2.8 cm from deep resection margin (closest margin). The remainder of the specimen shows a heterogeneous breast tissue. No other lesions or masses are grossly identified. The stroma to fat ratio is 3p.70. Multiple sections through the axillary contents reveal eighteen possible lymph nodes ranging in size from, 0.3 cm to 2.0 cm in greatest dimension. Representative sections are submitted as follows: 1 Superior resection margin nearest to the 1.00 o'clock mass 23 Inferior resection margin  Medial resection margin 4 Lateral resection margin 5 Deep margin closest to 1.00 o'clock mass (outer upper quadrant) 6 Deep margin ciosest to the second mass (outer upper quadrant) 7 Representative sections from the areola and nipple 8 Representative sections from the skin wit verrucose lesion 9-11  Representative sections from the mass at 1.00 o'clock (outer upper quadrant) 12-14 Representative sections from the second mass (outer upper quadrant) 15  Representative sections from inner upper quadrant 16 Representative sections from inner lower quadrant 17 Representative sections from outer lower quadrant 18-20 One lymph node multisected 21-23 One lymph node multisected 24&25 One lymph node multisected  26-33 One lymph node bisected per cassette 34 Four possible lymph nodes submitted in toto 35 Three possible lymph nodes submitted in toto ICD-9(s): 174.8 196.3 216.5 31/ Page 3 of 3
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diff --git a/output/text/a3e0f64a-f436-4609-ad63-4f3f6148348f.txt b/output/text/a3e0f64a-f436-4609-ad63-4f3f6148348f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..346e63feef1eace821e4ab6792dfeac4d75b462d
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SPECIMENS: NODES LEFT CERVICAL NECK FINAL DIAGNOSIS: LYMPH NODE, left CERVICAL NECK, excision: MALIGNANT LYMPHOMA, DIFFUSE, LARGE CELL TYPE (IWF G1). DIAGNOSIS COMMENT: Note: see fiow cytometry immunophenotypic report.. GROSS DESCRIPTION: NODES LEFT CERVICAL NECK Received in formalin is an irregular lymph node measuring. 1x0.5x0.7 cm. Tissue has been submitted for tissue procurement and flow cytometry. The remainder is submitted in B5 or formalin.. Date of surgery
+
+--- Page 2 ---
+SPECIMENS: BM BX RA BM BX LA FINAL DIAGNOSIS: BONE MARROW, right and left iliac crest biopsies, sections, imprints and smears: -ORDERLY HEMOPOIESIS -Negative for lymphoma DIAGNOSIS COMMENT: |BBone Marrow 1: Asp & Bx (No cytochem)|b Pt. Data: Hgb 13.2 WBC 9.65 Plat. 322.0 1. (UAspirate - Differential[u(%): Rt touch prep Cells Counted 500 Cellularity estimate 2+ M:E 2.8/1 Megakaryocytes: Dysplasia: Grade 0 Quantity: Normal [UMyeloid cells  Monos/Lymphs|u IUErythroid cells/Other|u Dysplasia Grade 0 Dysplasia Grade 0 2.0 myeloblasts NG monoblasts 0.2 pronorm. 4.4 promyelocytes NG promonocytes 25.0 normoblasts 12.2 myelocytes 0.4monocytes NG sideroblasts' 10.4 metamyelocytes 3.6 lymphocytes NG ring siderobl.** 22.2 bands/stabs NG lymphoblasts0.2 plasma cells 17.2 segs  NG abnormal lymphs 0.2 histiocytes 2.0 eosinophilic  NG unclass. blasts NG other 0.2 basophilic 71.0 TOTAL myeloid & mono *: as % of normoblasts; **: as % of all nucleated cells Comment on Diff: History of lymphoma. Orderly hemopoiesis. 1I.JU Biopsy datalu: 1.  Cellularity: 50% 2.  Myeloid/erythroid ratio: 3/1 3.  Myeloid series: Dysplasia: Grade 0 Quantity: Normal 4. Erythroid series: Dysplasia: Grade 0 Quantity: Normal 5. Megakaryocytes: Dysplasia: Grade 0 Quantity: Normal  Iron stores: Not evaluable 7. Abnormal infiltrate: None 8. Other: 9.  Comparison to Previous Bx: N/A GROSS DESCRIPTION: 1.BM BX RA Received in B5 and 37% formalin in bottle labeled with patient name and labeled bone marrow biopsy right is a  brown-tan core of bone measuring 0.5 cm. in length. Submitted in foto, 2.BM BX LA  Received in 85 and 37% formalin in bottle labeled with patient. name labeled bone marrow biopsy left are three  brown-tan fragments of core of bone measuring in aggregate length 0.7 cm. Submitted in toto.
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diff --git a/output/text/a3e3139e-3759-4501-a060-e3dcc466ba1c.txt b/output/text/a3e3139e-3759-4501-a060-e3dcc466ba1c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..80b863cfc619bdd5ec85eea463b8c21224cea0de
--- /dev/null
+++ b/output/text/a3e3139e-3759-4501-a060-e3dcc466ba1c.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:60F59595-9288-4388-978F-9E5848539EFA TCGA-BH-A0W5-01A-PR Redacted Patient history: None provided. LMP: Not provided. PRE-OP DIAGNOSIS: Left breast cancer. POST-OP DIAGNOSIS: Same. PROCEDURE: Left central lumpectomy, left sentinel lymph node.. CASE SYNOPSIS: SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST LATERALITy: i Left PROCEDURE: Segmental LOCATION: Not specified SIZE Of TUMOR: Maximum dimension invasive component: 1.4 cm MULTICENTRICITYAMULTIFOCALITY OF INVASIVE FOCI: No TumoR type (Invasive component):e Ductal adenocarcinoma, NOS nOTTInghAm scOre: Nuclear grade: 2 Tubule tormation: 2 Mitotic activity score: 2 Total Nottingham score: 6 Nottingham grade (1, 2, 3): 2 ANGIOLYMPHATIC INVASION: Yes DERMAL LYMPHATIC INVASION: No CALCIFICATION: Yes, benign zones Yes, malignant zones Tumor type, in situ: Cribriform Percent of tumor occupied by in situ component: 5 % SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No SURG MARGINS INVOLVED by IN SITU COMPONENT: No Paget's Disease of nipple:  No LyMPH NODES POSITIVE: 1 LymPh NODeS EXAMINeD: 2 MetHOD(S) Of Lymph nOde EXAminATiON: H/E stain SENTINEl NODe METASTASIS: Yes SIZE OF NODAL METASTASES:  Diameter of largest lymph node metastasis: 5 mm LymPH NODE METASTASIS(-ES) WITH EXTRACAPSULAR EXTENSION: Yes NON-NEOPLASTIC BREAST TISSUE: ADH, FCD t stage, PathologIC: pT1c Ics-o - N stage, pathologic: pN1 m Stage, Pathologic: pMX N0c Estrogen receptors: positive Cacumn PRogesterone Receptors: positive 8 5vo/3 HER2/NEU: 2+ Sits: brot, n0s c50.9
+
+--- Page 2 ---
+FINAL DIAGNOSIS: Part 1: Left Breast, Segmental mastectomy -- A.* iNFILTRATiNG DUCT CARCINOMA, 1.4 X 1.2 X 1.2 CM ASSOCIATED WITH MICROCALCIFICATIONS.  NOTTInGHAm SCORE 6/9 (TUBULES 2, NUCLEI 2, MITOSIS 2). c.  DUCTAL CARCINOMA IN SITU, CRIBRIFORM TYPE, NUCLEAR GRADE 2, COMPRISING 5% OF INVASIVE TUMOR. D. SURGICAL MARGINS NEGATIVE. E.  NiPPLE AND SKIN, NEGATIVE FOR TUMOR. F. CHANGES CONSISTENT WITH PREVIOUS CORE BIOPSY SITE. G. TUMOR iS ESTROGEN RECEPTOR POSITIVE, PROGESTERONE RECEPTOR POSITIVE AND hER-2/NEU IS EQUIVOCAL (SCORE 2+). NO AMPLIFICATION OF HER-2/NEU GENE WAS SEEN FOR INTERPHASE FISH ANALYSIS. H. FIBROCYSTIC CHANGES. 1. FOCAL ATYPICAL DUCTAL HYPERPLASIA. J.  MICROCALCIFICATIONS ASSOCIATED WITH BENIGN DUCTS. K. THERMAL EFFECT. PARt 2: SEnTiNeL LymPh nODE #1, BIOPSy - A. ONE LymPH nODE, POSITIVE FOR mETASTATiC CARcinOmA (1/1). B. METASTATIC TUMOR MEASURES 0.5 CM AND SHOWS EXTRACAPSULAR EXTENSION.E PART 3: SENTineL Lymph nODE #2, BIOpSy - One Lymph nODe, NEgATiVE fOR TUmOR (0/1)
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diff --git a/output/text/a3f9d408-36ce-4713-ac0d-1836565fb0a2.txt b/output/text/a3f9d408-36ce-4713-ac0d-1836565fb0a2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2a52ee0308f2d942d8bc80ad8099153ba9605d60
--- /dev/null
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+
+--- Page 1 ---
+Patient Name Accession #: Med. Rec. #: Date of Procedure: DOB: Date of Receipt Gender: Date of Report: Ret. Physician Account #: Patient Address: Billing Type: Additionat Copy to Ref. Source: Clinical Diagnosis & History: 79 y/o male with left renal mass. Specimens Submitted: 1: SP: Kidney, Left, Total nephrectomy: 2: SP: Lymph nodes, Lelt suprahilar and hilar and left adrenal, resectic. 3: SP: Lymph nodes, Para-arotic, excision DIAGNOSIS: SP: Kidnoy, Loft, Total nephrectomy: Tumor Type Renal coll carcinoma - Papillary type. Type 2 Fuhrman Nuclear Grade: Nuclear grade IIIV Tumor Size Greatest diametor is 7.5 cm. Local Invasion (for renal cortical types): Extends through renal capsule but confined within Gerola's fascia. Renat Vein Invasion: Not identified Surgical Margins: Free of tumor Non-Neoplastic Kidney: Chronic inflammation Adrenal Gland: Not identified Lymph Nodes: Not identified  Staging for renal cell carcinoma/oncocytoma:  pT3a Tumor invades the adrenol gland or perinephric tissues bul not beyond Gerota's fascia 2. Lymph nodes, lell suprahilar and hilar and left adrenal, resection:. - Renal cell carcinoma, papillary lype involving perirenal adipose tissue.. Page 1 of 3
+
+--- Page 2 ---
+. Unremarkable adrenal gland. 3. SP: Lymph nodes, Para-arotic, excision Lymph Nodes:  Number of nodes examined:11 Number of metastatic nodes:6 The largest melastatic node is 3.5cm  Perinodal (extracapsular) extension identified ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES AND/OR OTHER MATERIAL).ANO IHAT IHAVE REVIEWED AND APPROVEO THIS REPORT Gross Description: 1) The spccimen is received lresh labeled "lefl kidney" and consists of a kidney with attached ureter, renal vessels and perinephric Iat weighing 285 g in total. The kidney measures 10.0 x 6.5 x 4.5 cm. 1he attached ureter measures 2.5 cm in length and 0.5 cn  in diameter. The attached renal yein measures 0.8 cm in length and 0.7 cm in diameter. The renal vessels and ureter margins are. grossly unremarkabie. An adrenal gland is not identified grossly. The kidney is inked black and bivalved to reveal an ill-defined bright-yellow tumor, tocated at mid portion of xidney and protruding oul and involving the perinephric fat, measuring 7.5 x 5.5 x 5.0. cm. Sections through the remainder of the kidney reveal a pink brown parenchyma, with a well-defined corlico-medullary junction.. The cortex measures 1.0 cm and the calyces appear normal. No lymph nodes are identified in the perinephric fat. Represenlalive sections are submitted for TPS and for permanent sections.. Summary of sections:  UVM -- ureteral and vessel margins tumor THF-- tumor with hilar fat TSF -- tumor with sinus fat. TK -- tunor with adjacent kidney RP -- renal pelvis representative sections K -- representative sections kidney F-hilar fat 2) The specimen is received fresh labeled *Lelt suprahilar, and hilar lymph node and left adrenal'. It consists of a segment of yellow-tan fatly lobular tissue containing the adrenal gland and adjacenl encapsulated, seemingly intact red-brown mass. The Overall dimensions of the specimen are 14.5 x 5 x 3 cm. The adrenal measures 4.5 x 1.2 x 1 .0 cm, and on cut section shows. unremarkable yellow orange appearance. The red-brown mass measures 4 x 4 x 3 cm, is located directly adjacent to the adrenal gland, but does not show any definile involvement of the gland. The outer surface of the mass is inked black. On cul seclion of. the mass, it shiows cystic, markedly friable dark red hemorrhagic appearance filled with hemorrhagic naterial No lynph nodes are grossly idenlified. Representative seclions are submitted.. A sample of the mass is given to TPS. The specimen has been photographed. Summary of sections: ADR-adrenal M-Mass ADRM-adrenal and mass 3). The specimen is received in formalin labeled *Para-aortic tyinph nodes*. It consisls of multiple lymph nodes ranging from 0.3 x 0.3 cm up to 3.5 x 2.5 cm in greatest dimensions. Cut section of one of the largost lymph nodes shows moltled yellow orange lo.  Page 2 0f 3
+
+--- Page 3 ---
+black appearance. Representative sections of this and one ol the lymph node are submitted. The iargesl lymph node is.  quadrisecled to show predominantly yellow-tan falty lobular appearance with tocal firm white-tan areas. After the largest lymph node is quadrisected, each of the sections is bisected. The remainder of the lymph nodes are entirely submitled.. Summary of sections:. A-section of largest lymph node, bisecled  B- section of largest lymph node, bisected C-section of largest lymph node, bisected D-section of largest lymph node, bisected RS1-representative sections of one of the largest lynph nodes RS2- representalive section of one of the largest lymph nodes, bisected. LN ~ lymph nodes BLN1 - bisecled lymph node 1 8t.N2 - bisecled lymph node 2 BLN3 - bisected lymph node 3 Summary of Sections:. Part 1:  SP: Kidney, Loft, Total nephrectomy! Block Sect. Site PCs 1 1 1 k 1 1 rp 5 t 5 1 thf tk 1 tsf * 1 uvm 1 Part 2:  SP: Lymph nodes, Left suprahilar and hilar and left adrenal, resoction. Block Sect. Site PCs 3 adr 3 1 adrm 1 5 m 5 Part 3:  SP: Lymph nodos, Para-arotic, excision Block Soct. Site PCs ? a NN 2 b 1 bln1 1 1 bln2 + 1 bln3 1 2 c 2 2 d 2 1 In 1 rs1 2 2 rs2 2 Page 3 of 3 END OF REPORT
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diff --git a/output/text/a3fb285a-7941-410a-a9a9-fbeaec757f99.txt b/output/text/a3fb285a-7941-410a-a9a9-fbeaec757f99.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2201f6c8b6707b5664f0fa2675a6141e29630954
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+
+--- Page 1 ---
+Pathology Report DIAGNOSIS (A) LEFT KIDNEY, ADRENAL, AND PERIAORTIC LYMPH NODES: CHROMOPHOBE RENAL CELL CARCINOMA (11.0 CM MAXIMUM DIMENSION), EOSINOPHILIC VARIANT, FUHRMAN NUCLEAR GRADE 4, INVASIVE INTO PERINEPHRIC ADIPOSE TISSUE AND RENAL SINUS ADIPOSE TISSUE, WITH VASCULAR-LYMPHATIC INVASION. (SEE COMMENT) METASTATIC CHROMOPHOBE RENAL CELL CARCINOMA IN 3 HILAR LYMPH NODES. Adrenal gland, no tumor present. Margins of resection free of tumor. (B) SPLEEN: Spleen with vascular congestion, no tumor present. The chromophobe renal cell carcinoma in the left kidney extensively invades into the perinephric adipose tissue, including around the adrenal gland. However, tumor does not invade directly into the adrenal gland. Tumor is also present within the renal sinus adipose tissue. The renal vein is free of tumor. The lymph nodes are extensively involved by chromophobe renal cell carcinoma. Immunohistochemical stain for EMA is strongly positive in the tumor cells. Cytokeratin 7 is positive in a minority of the tumor. CD10 is focally positive, including rare cells that show a membranous staining pattern. Vimentin is negative. Electron microscopy shows that the tumor is made of cuboidal cells with abundant cytoplasm containing a large number of mitochondria with tubular cristae. The cytoplasm contains a large number of microvesicles. The ultrastructural features of the tumor are those of a chromophobe renal cell carcinoma, eosinophilic variant. The electron microscopy was performed by Dr GROSS DESCRIPTION (A) LEFT KIDNEY, ADRENAL, AND PERIAORTIC LYMPH NODE - A radical nephrectomy specimen consisting of a left kidney (28.0 x 17.0 x 10.0 cm) and associated adrenal gland (7.0 x 4.0 x 1.5 cm). Within the renal hilum is an aggregate of enlarged. lymph nodes (8.0 x 3.5 x 2.0 cm). Within the upper pole and mid-portion of kidney is an 11.0 x 9.0 x 6.0 cm, lobulated, relatively well-circumscribed tumor which extends through the renal capsule into the perinephric fat, including around the adrenal gland. The tumor grossly involves the renal sinus. The cut surface of the tumor has a variegated appearance, with tan-pink fleshy areas as well as gray-brown necrotic areas (necrotic areas comprise less than 10% of tumor). Other areas have thickened gray-white fibrous septa which traverse the tumor. The ureteral and vascular margins are grossly free of tumor. The renal vein is free of tumor. Three hilar lymph nodes are grossly involved with tumor and measure 4.8 x 1.5 x 1.0 cm, 2.5 x 2.0 x 2.8 cm, and 1.6 x 1.0 x 1.0 cm, respectively.. The cut surface of the positive lymph nodes have a pink-tan fleshy appearance. The renal tissue away from the tumor is pale brown and unremarkable. The cortex has a thickness of 0.8 cm, and the corticomedullary junction is well-delineated. SECTION CODE: A1-A4, tumor extending into perinephric fat; A5, tumor with gray-white fibrous septa; A6, tumor in perinephric fat; A7, tumor and adrenal; A8-A10, tumor and renal sinus; A11, tumor with area of necrosis; A12, tumor/ normal. kidney interface; A13, tumor; A14-A16, largest lymph node; A17, smaller lymph node, representative section; A18, smaller lymph node, representative section; A19, renal vascular and ureteral margins; A20, A21, uninvolved renal tissue. (B) SPLEEN - An 11.5 x 7.8 x 5.0 cm spleen which has an intact smooth gray capsule and a purple unremarkable cut surface. No  masses are present. The hilum contains a small amount of adipose tissue. Representative sections are submitted in B1-B4.. CLINICAL HISTORY Mass, left renal..
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diff --git a/output/text/a449b964-359e-4fae-a88e-42b073aca0a4.txt b/output/text/a449b964-359e-4fae-a88e-42b073aca0a4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..21973dcc8ad6b779aec7b61d782632f9316fe727
--- /dev/null
+++ b/output/text/a449b964-359e-4fae-a88e-42b073aca0a4.txt
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+
+--- Page 1 ---
+TCGA-A6-2680 SPECIMEN Extended right hemicolectomy CLINICAL NOTES PRE-OP DIAGNOSIS: Hepatic flexure cancer.. POST-OP DIAGNOSIS:  Same. GROSS DESCRIPTION Received unfixed for tissue procurement, labeled "extended. right hemicolectomy" is a portion of the ileum that is 9.5 cm in length, and 3 cm in circumference.. There is an attached portion of colon that is 22 cm, which includes the cecum and. ileocecal valve.  The average circumference of the colonic portion. of the specimen is 7.3 cm. Wall thickness is, on average, 0.4 cm. In the distal end of the colonic segment is a tumor that is circumferential, with raised, rolled edges and central ulceration, 9 x 4.2 cm in cross sectional area. The tumor mass is 5.7 cm from the distal margin, and 24 cm from the proximal ileal margin. The mass is 1 cm from the ileocecal valve. A portion of tumor and normal tissue is submitted for tissue procurement.. Sectioning through the. tumor shows subserosal invasion, but the mass does not reach the serosal surface. Representative sections submitted in 13 blocks as. labeled. Rs-13 BLOCK suMMARy: 1 - proximal and distal margins; 2-4 - tumor full thickness to inked free radial serosal surface; 5 - tumor to normal mucosa; 6 - Icv; 7 and 8 - random colon; 9-11 - 9 whole lymph nodes per cassette; 12 - 8 whole lymph nodes; 13 - 1 bisected lymph node. MICROSCOPIC DESCRIPTION Histologic type:  Adenocarcinoma Histologic grade: Moderately-differentiated. Primary tumor (pT3):  carcinoma invades through the muscularis. propria into the subserosa.. Proximal/distal/circumferential margin: Negative Distance of tumor from closest margin: 5.7 from distal margin Vascular invasion: Not identified Regional lymph nodes (pn0): 34 negative lymph nodes (0/34). Non-lymph node pericolonic tumor: not identified.. Comment: There is a small nodule of surface tumor submitted with lymph nodes; slide also reviewed by. who agrees with this interpretation. 5 DIAGNOSIS Colon, hepatic flexure, extended hemicolectomy: Adenocarcinoma, moderately-differentiated, with invasion through the muscularis propria into the subserosa (pT3). Margins of excision negative. Angiolymphatic invasion not identified.. Thirty-four negative lymph nodes (0/34).
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diff --git a/output/text/a459dce9-3de4-4231-8e35-059af00b28c1.txt b/output/text/a459dce9-3de4-4231-8e35-059af00b28c1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5c6893f9fd1ad3b7fa9046ba25ae7b661a62a127
--- /dev/null
+++ b/output/text/a459dce9-3de4-4231-8e35-059af00b28c1.txt
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+
+--- Page 1 ---
+UUID:F18AFE4B-5333-418A-A6D0-E347ACA3C068 Requesting Doctor's Intormatlon: TCGA-OR-A5I-01A-PR Redacted Ccrcins mo., adceno! cortic 83/3 Site B Adveual Cland, cortex 074.D [80) 13 A SPECIMEN TYPE:  Adrenal T h CLINICAL NOTES: Right adrenal gland. Lap Rt adenalectomy -> incidentally found complex Rt 0 adrenal lesion. L MACROSCOPIC: 0 'Right adrenal gland'. The specimen corsists of an adrenal gland 70 x 45 x G 40mm weighing 26g with scanty attached fatty tissue up to 5mm wide. One surtace of the adrenal capsule is disrupted. On sectioning a yellow lobulated Y nodule 40 x 30 x 30mm with central cystic change and haemorrhage is present within the adrenal gland. The surrounding adrenal gland shows normal cortex and medulla. The nodule appears encapsulated by a fine capsule with no invasion into adjacent fat. Block 1: adjacent normal adrenal gland. Blocks 2 to 6: representative nodule. Blocks 6 to 11: MICROSCOPIC: A The 40 mm adrenal lesion is a low grade adrenal cortical carcinoma. It fulfils 3 of the Weiss criteria ot malignancy (predominantly eosinophilic cell type, N cytological atypia, diffuse architecture). The tumour is contined to the A adrenal and separated from the soft tissue margin but an intact psedocapsule indicating that local excision is complete. The mitotic rate is low (less than T 1 mitosis per 10 hpt). No atypical mitoses are identified. There is no. 0 coagulative necrosis. There is no vascular or sinusoidal invasion. Numerous eosinophilic cytoplasmic globules (a feature associated with malignancy) are M present. There is some myxoid change.. 1 Immunohistochemistry supports the diagnosis of carcinoma and confirms adrenal c cortical origin. It is as follows: IGF2: Diffusely strongly positive with parinuclear dot-like staining A Ki-67: Low proliterative index (4%) L Calretinin: Positive MelanA: Positive S-100: Negative P Chromogranin: Negative W iy> A SUMMARY: Right adrenal gland: Low grade adrenal cortical carcinoma 40 mm. T H 0 0
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+Diagnosis: Right-sided hemicolectomy preparation with locally advanced, poorly differentiated mucinous adenocarcinoma of the cecum (G3) with invasion of all parietal layers, penetration of the peritoneum, spreading to a gathered loop of small intestine, multiple regional lymph node metastases and carcinosis of the peritoneum or omentum (pT4 L1 V0 pN2 9/10 pM1
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diff --git a/output/text/a4ab74c9-21dd-46c9-9ba5-83a263695339.txt b/output/text/a4ab74c9-21dd-46c9-9ba5-83a263695339.txt
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index 0000000000000000000000000000000000000000..e268a6e539fbc4d3c5b7a2a54ba570bae2e89b03
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+Page 1 of 2. UUID:97EA8988-20F9-4E07-B2A5-C03584DAC700 TCGA-UD-AAC1-01A-PR Printed DOB: CLINICAL HISTORY: Right mesothelioma. MACROSCOPIC: Norr Right pleural mesothelioma: Roughly triangular shaped piece of pleural File tissue measuring 100mm x 70mm and up to 15mm in thickness.  The  Note surfaces appear nodular and irregular with some haemorrhage present on Requi both surfaces. The pleura appears thinner towards the tailing narrow end which measures up to 35mm.. There appears to be a cut through the  Patie Nouifi nodular thickened area. The cut surface shows a lobulated and whorled grey tan yellowish cut surface focally. Specimen is sliced from the.  Patie hicker end to the thinner and the cut surface is relatively Will ( nomogeneous from one end to the other (A-G 7xl, H 1xM, MICROSCOPIC: Mak Sections show the specimen to be almost entirely infiltrated by a Appoint malignant tumour.  The tumour is forming nests and poorly formed Colle glandular structures and is composed of epithelioid cells with round Prescri] nuclei, prominent nucleoli and abundant eosinophilic cytoplasm. The tumour infiltrates from the pleural surface through fat and focally is Ou Co1 Treatir seen at the deep margin of the biopsy. Geographic areas of necrosis. are evident.  A focal papillary pattern is seen along the surface. Check Doct Page 1 of. M Contidentiality: This document is confidential. If you are not the intended recipient you must not read, copy, distribute or act in. reliance on it. if you have recieved this document in error please notify us immediately and destroy the original message. TCD-O.3 9sz|3 masait dite:B yJwo C38.4 JtJ 1/29/14
+
+--- Page 2 ---
+aye DOB Sex: Immunoperoxidase stains show strong staining with Cam5.2 and calretinin, weaker staining with cD5/6 and no staining with cEA or Norm BerEp4. Nott CONCLUSION: Requi Right pleural lesion:  Deeply invasive malignant mesothelioma. Tumour extends up to the deep margin of excision. Patie Notif.  Patie Will( Mak Pathologist: Appoim Collk Prescri Page 2 of 2 On Co Treatn Check Doct M Confldentiality: This document is confidential. If you are not the intended recipient you must not read, copy, distribute or act in rellance on it. If you havs recieved this document in error please notify us immediately and destroy the original message. Dq - r unKnow~ d+aif5(when,whnt+ypi adry pleuroclesis w418/13
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diff --git a/output/text/a4b10f00-f47a-473d-a6b4-6d337c72712f.txt b/output/text/a4b10f00-f47a-473d-a6b4-6d337c72712f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..179ffb27b480bf9f9556c27cfdd909d520994ebb
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+ID b3 UUID:4450C905-2199-4DF3-A17B-450736D6F403 TCgA-2Z-A9JN-01A-PR Redacted 'arcinsm@, yelyillouy Nna. eeQQ 8QbOJ3 Pathology Report 4J|28/14 Final Diagnosis A. RIGHT PARTIAL NEPHRECTOMY: Oncocytic variant of papillary renal cell carcinoma, Fuhrman nuclear grade 2-3, confined to the kidney (See Comment and See Key Pathological Findings). Parenchymal resection margin, free of tumor (tumor located a fraction of a mm from the. margin). Pathologic stage: pT1a NX MX. B. DEEP MARGIN: Renal parenchyma, no tumor present. I the attending pathologist, personally reviewed all slides and / or materials and rendered the final diagnosis. Electronically. signed.Out by Comment The tumor cells are arranged in papillae and tubules and exhibit moderate amount of pink eosinophilic cytoplasm. Areas of papillae formation with foamy histiocytes are present. There is a single layer of tumor cells with luminally placed nuclei. No nuclear stratification is identitied. Immunohistochemical stains performed show the tumor cells to be strongly positive for cytokeratin 7 and E-Cadherin, focally positive for vimentin with weak and focal positivity for racemase. The tumor. cells are negative for CD10, RCC and CD117. Key Pathological Findings Tumor type: Oncocytic variant of papillary renal cell carcinoma Nuclear grade: Predominantly 2, focally 3. Tumor size: 3.2 x 3.2 x 2.3 cm Pattern of growth: Tubular and papillary Renal capsule invasion: Not identified Invasive of perinephric adipose tissue: Not applicable Renal vein invasion: Not applicable Surgical margins: Free of tumor Lymphovascular invasion:. Not identified Perineural invasion. Not identified Adrenal gland: Not applicable Lymph nodes: Not applicable Pathologic stage: pT1a NX MX Specimen(s) Received RIGHTPARTIALNEPHRECTOMYFS
+
+--- Page 2 ---
+B DEEP MARGIN FS Clinical History None provided. Preoperative Diagnosis Right renal mass. Intraoperative Consultation FSA1.RIGHTPARTIALNEPHRECTOMY Oncocytic lesion. FSB1.  DEEP MARGIN: Negative. Comment: This frozen section diagnosis/result was communicated to and acknowledged by Dr. , M.D., have performed the intraoperative consultation and issued the above. diagnosis. Gross Description A.  Part A is received fresh for frozen section consult, labeled *right partial nephrectomy.. ink-margin" and consists of an oriented segment of renal tissue, 23.5 g, 5.1 x 3.7 x 2.9 cm. The capsule is intact and smooth with scant soft tissue (ink black)and the deep parenchymal margin is inked blue. The cut surfaces exhibit a circumscnbed pale tan tobulated rubbery tumor mass, 3.2 x 3.2 x 2.3 cm. The mass approximates the deep parenchymal margin, separated by a submillimeter of membrane. The mass is interspersed with fibrosis.Minimal focal cysts are noted,however,no necrosis or hemorrhage is identified. The normal parenchyma is dark tan and smooth. Representative sections are submitted as FSA1-A8 as labeled FSA1: Frozen section of renal lesion with nearest capsule. A2-A3: Cross section of renal lesion with fibrosis, bisected and mirror image sections submitted for Tissue Procurement Laboratory. A4-A5. Cross section of renal lesion, bisected A6-A7: Cross section of renal lesion, bisected A8: Cross section of renal lesion.. The specimen is submitted for Tissue Procurement Laboratory.. B.  Part B is received fresh for frozen section consultation, labeled "deep margin: ink-margin* and consists of an oriented dark tan renal sliver, 1 x 1 x 0.5 cm. The inked margin is re-inked blue. Sectioned perpendicular, the cut surfaces exhibit unremarkable smooth parenechyma. No lesion is grossly seen. The specimen is submitted ertirely in FSB1. The specimen is not submitted for Tissue Procurement Laboratory..
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diff --git a/output/text/a4d0b72c-3e18-421c-aa03-af2514ff9075.txt b/output/text/a4d0b72c-3e18-421c-aa03-af2514ff9075.txt
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+JUID:30 TCGA-AN-A0FS-01A-PR Redacted TSS Patient ID Case #: I DOB:. Sex: Ethnicity (Race) Cancer Sample Diagnosis: Breast Cancer Histological description: Infiltrative lobular carcinoma Date of Procurement: - : : Anatomic Site: Right breast Tumor location: Primary Tissue Specification: Tumor Specimen Matrix: Tissue Specimen Format: OCT Container: block Type of Procurement: surgery Grade: 2 T Stage: 1 N Stage: 0 M Stage: 0 Treatment: none Treatment Details: n/a  Normal Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw Matrix: Blood Specimen Format: frozen Container: tube Date of Procurement: CQcF: cani mn,mnfltnuHny ductl nos 85o|3 Pash carcnoma, inifHtnsHnz 1obulw,nos 85ao/3 Site: brest Nos C5o.9 lw Pa4h nprt shows tumn es 1obulur and CQcF statx TC6A tmn is ductl. aftw tmail confumaton wiH Tss, 73s 16/2
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diff --git a/output/text/a4f9601e-eaba-4511-a2fd-2ae62e9a6557.txt b/output/text/a4f9601e-eaba-4511-a2fd-2ae62e9a6557.txt
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index 0000000000000000000000000000000000000000..a9b94774cb981e34669e7974f5f9b9fcba68251c
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+1cs-0-3 Chcin oma heyatotllulur,N0s 817o/3 Site: live C 22.0 4/8/ SURGICAL PATHOLOGY Case Number : Diagnosis: Liver, segment 3, partial hepatectomy. - Hepatocellular carcinoma, grade 3 (Edmondson and Steiner classification) - Tumor size: 7.4 cm - Margins: negative for tumor. - Capsule involvement: not identified. - Lymphovascular space invasion identified (A4) - Background liver: steatosis affecting .approximately 5% of liver parenchyma - AJcc pathologic stage: pT2 pNx UUID:FEA652A1-DD1E-4D78-87DF-FC2162267A96 TCGA-BC-A217-01A-PR Redacted Clinical History: i-year-old female with hcc. Gross Description: Received is one appropriately labeled container, additionally labeled "resection Segment 3." It holds a 235.4 gram, 11 x 10 x 7.5 cm partial hepatectomy specimen. The specimen is partially covered with a smooth, red/tan capsule with focal hemorrhagic fibrofatty adhesions. The parenchymal margin is marked with blue ink and the specimen is sectioned to reveal a 7.4 x 6.1 x 4.9 cm well circumscribed fleshy lobulated mass with focal areas of hemorrhage. The mass is. located beneath the capsule and focally abuts the blue inked parenchymal margin. The surrounding hepatic parenchyma is tan/brown with focal induration and discoloration along one edge of the tumor.. Tumor and normal are given to Tissue Procurement. Block summary: Al - discolored edge of hepatic parenchyma adjacent to tumor A2 - tumor and overlying capsule KX4
+
+--- Page 2 ---
+A3 - tumor in relationship to blue inked parenchymal margin A4 - tumor and parenchyma. A5 - tumor and capsule. A6-A8 - additional sections from tumor. Light Microscopy:. Light microscopic examination is performed by Dr.. Signature Attendina Pathologist: , MD. I have personally conducted the evaluation of the above specimens and have. rendered the above diagnosis(es).. Electronically Signed by:, MD Date
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+ UUID:AFA683D5-E514-42B0-84AA-251724FDBFBC Redacted TCGA-JY-A93C-01A-PR Surgical Pathology Consultation Report Patient Name: Accession #: MRN: Service: Collected: DOB: Visit #: Received: Gender: M Location: Reported: Facility: Ordering MD: Copy To: TD-0.3 Specimen(s) Received 1. Lymph-Node:  ST19 Splenic nodes lemcCsusursms NDS 814c/3 2. Lymph-Node:  ST20 Celiac nodes 3. Lymph-Node: ST18 Common Hepatic nodes 4. Lymph node: INF pulm ligament ST9L 5. Esophagus: thoracic esophagus and procimal stomach esophageal margin QS. C155 6. Lymph node: station 7. 7. Lymph node: station 17 HJ<118J14 8. Lymph node: station 16 9. Lymph node: station 8. 10. Esophagus: final oesophageal margin 11. Soft Tissue: final gastric margin 12. Soft Tissue: final #2 gastric and oesophageal ring margin Diagnosis 1. Lymph-Node:  ST19 Splenic nodes: - lymph node x1: negative for carcinoma - adipose tissue with no significant abnormality 2. Lymph-Node:  ST20 Celiac nodes: - lymph nodes x4: negative for carcinoma 3.Lymph-Node:  ST18 Common Hepatic nodes: - adipose tissue with no significant abnormality 4.Lymph node: INF pulm ligament ST9L: - lymph node x1: negative for carcinoma 5. Esophagus (thoracic) and proximal stomach (esophageal margin QS), resection: - adenocarcinoma of distal esophagus, moderately to poorly differentiated, with mucinous component , involving GEJ and extending into proximal stomach, invading adventitia -- see synoptic data and comment - resection margins: negative for carcinoma - see comment. - metastatic adenocarcinoma in 3/17 lymph nodes (total lymph node count includes specimens #1, #2, #4, and #6 to #9) 6. Lymph node: station 7: - lymph nodes x3: negative for carcinoma -- see comment. 7. Lymph node: station 17: Page 1 of 5
+
+--- Page 2 ---
+Surgical Pathology Consultation Report. - metastatic adenocarcinoma in 2/2 lymph nodes 8. Lymph node: station 16: - lymph nodes x2: negative for carcinoma. 9. Lymph node: station 8: - metastatic adenocarcinoma in 1/4 lymph nodes 10.  Esophagus: final oesophageal margin: - negative for carcinoma 11. Stomach: final gastric margin:. - negative for carctrioma 12. Stomach and'esoptagus: final #2 gastric and esophageal ring margin:. - negative for carcinoma . Comment 5 and 6. The tumor involves dista! esophagus and extends into the stomach for a distance of 2.0 cm. The tumor is focally ~ 0.5 mm from the esophageal adventitial margin and also involves perigastric fat. The proximal part of the tumor is polypoid and is in a background of intestinal metaplasia in residual glandular mucosa.. There is focal mucinous differentiation with small mucin pools and there is focal area of poorly differentiated tumor. The. mucinous component represents approximately 20% of the tumor. There is metastatic adenocarcinoma in 3/17 lymph nodes identified. There is infiltration of perinodal adipose tissue in specimen #7, labeled lymph node station 17.. One lymph node in specimen #6, labeled lymph node station 7, shows small hyalinized nodules with anthracotic pigment and microscopic birefringent particles. There are no acid fast bacilli or fungi are identified by the ZN and PAS stains. Synoptic Data Clinical History: Not known: Specimen: Esophagus Proximal stomach Procedure: Esophagogastrectomy Primary Tumor Site: Distal esophagus (lower thoracic esophagus) Additional Sites Involved by Tumor: Esophagogastric junction (EGJ)  Proximal stomach and esophagogastric junction Relationship of Tumor to Esophagogastric Junction: Tumor midpoint lies in the proximal stomach or cardia and tumor involves the. esophagogastric junction Distance of tumor center from esophagogastric junction: 1.5 cm Histologic Type: Adenocarcinoma Histologic Grade: G3:  Poorly differentiated Tumor Size: Greatest dimension: 3.8 cm Additional dimension: 1.9 cm Additional dimension: 0.6 cm Microscopic Tumor Extension: Tumor invades through the muscularis propria into the periesophageal soft tissue. (adventitia) Proximal Margin: Uninvolved by invasive carcinoma. Uninvolved by dysplasia Distal Margin: Uninvolved by invasive carcinoma. Uninvolved by dysplasia Circumferential (Adventitial) or Deep Margin: Uninvolved by invasive carcinoma. All Margin Status All margins uninvolved by invasive carcinoma Distance of invasive carcinoma from closest margin: 0.5 mm Closest margin: Circumferentia!. Treatment Effect: No prior treatment Page 2 of 5
+
+--- Page 3 ---
+Surgical Pathology Consultation Report Lymph-Vascular Invasion:. Present Perineural Invasion:e Present TNM Descriptors: Not applicable: . Primary Tumor (pT): pT3: Tumor invades adventitia Regional Lymph Nodes (pN): pN2: 3 to 6 nodes involved Number of regional lymph nodes examined: 17. Number of regional lymph nodes involved: 3. Distant Metastasis (pM): Not applicable: . Additional Pathologic Findings: *Intestinal metaplasia (Barrett's esophagus) *Pathoiogic Staging is based on AJCC/UICC TNM, 7th Edition Electronically verified by: Clinical History esophageal ca Gross Description 1. The specimen is labeled with the patient's name and as "St 19 splenic nodes". Number of yellow tissue pieces:  3 Measurements: 0.8 x 0.4 x0.2 cm to 2 x 1.3 x 0.4 cm. 1A submitted in toto 2. The specimen is labeled with the patient's name and as "sT20 celiac nodes". Number of yellow tissue pieces: 4 Measurements: 0.3 x0.3x0.3cm to 1 x 0.5 x 0.4 cm. 2A submitted in toto. 3. The specimen is labeled with the patient's name and as "ST18 hepatic nodes" One piece of yellow tissue measuring 1.4 x 0.5 x 0.3 cm. 3A submitted in toto 4. The specimen is labeled with the patient's name and as "inferior pulmonary ligament ST9L" One piece of gray tissue measuring 0.3x0.3x0.2cm. 4A submitted in toto 5. STOMACH RESECTION FOR TUMOR GROSS EXAMINATION RESECTION SPECIMEN:  proximal gastrectomy and distal esophagus FIXATION: Fixed DIMENSIONS: Page 3 of 5
+
+--- Page 4 ---
+Surgical Pathology Consultation Report Length along lesser curvature 4.5 cm. Circumference of distal gastric margin 12.8 cm Length of tubular esophagus if present 5 -cm circumference esophagus margin 5.0 cm TumOR: LOCATION:  distal esophagus, GEJ and proximal stomach  lesser curvature  proportion of tumor mass located in esophagus & stomach: 1.5 cm long in esophagus and 2.0 cm long : in stomach - CONFIGURATION: exophytic - DIMENSIONS: Diameters3.8 x 1.9 cm Depth0.6 cm - DESCRIPTIVE CHARACTERISTICS: tan and solid - PERFORATION: no - DISTANCE FROM MARGINS: - PROX|MAL 3.3 cm - DistAL 1 cm -RADIAL 0.1 cm ESTIMATED DEPTH OF INVASION: into adventitia LESIONS IN NONCANCEROUS STOMACH: no LYMPH NODES: perigastric lymph nodes along the greater and lesser curvatures: no. 2 pieces of tumor, one piece of mucosa of esophagus and one piece of gastric mucosa stored frozen. Representative Sections: 5A-5B esophageal margin en face frozen sections resubrnitted 5C-5D distal margin en face frozen sections resubmitted 5E-5G remaining gastric margin en face 5H-5N upper half of tumor in toto sequentially 5O-5T rest of tumor in toto sequentially. 5U transverse section of esophagus above tumor 6. The specimen is labeled with the patient's name and as "station 7". Number of fatty tissue pieces: 2 Number of nodes: 3 Measurements: 1 x 0.8 x 0.3 cm to 3 x 1.2 x 0.6 cm. The nodes are submitted in toto. 6A 2 nodes 6B and 6C 1 node bisected 7. The specimen is labeled with the patient's name and as "station 17". Number of fatty tissue pieces:  1 Measurements:4.5 x 4.5 x 2.5 cm. 2 nodes identified measuring 0.1 x 0.1 x 0.1 and 1.6 x 0.8 x 0.9 cm. The nodes are submitted in toto. 7A 1 node 7B 1 node bisected Page 4 of 5
+
+--- Page 5 ---
+Surgical Pathology Consultation Report 8. The specimen is labeled with the patient's name and as "station 16" Number of fatty tissue pieces:1 Measurements: 4 x 3 x 0.5 cm. 2 nodes identified ranging in size from 0.1 x 0.1 x 0.1 to 0.3 x0.3x0.3 cm. The nodes are submitted in toto. 8A 2 nodes 8B 1 possible node 9. The specimen is labeled with the patient's name and as "station 8". Number of fatty on tissue pieces:  1 Measurements: 8x3x0.5 cm. 4 nodes identified ranging in size from0.1 x 0.1 x 0.1 to 1 x 0.4 x 0.3 cm The nodes are submitted in toto. 9A 2 nodes 9B 2 nodes 10. The specimen is labeled with the patient's name and as "final esophageal margin". It consists of a stapled line margin measuring 3 x 0.4 x 0.3 cm. 10A soft tissue shaving 11. The specimen is labeled with the patient's name and as "final gastric margin". It consists of a segment of staple line margin measuring 6 x 2 x 1.8 cm. 11A-11C the staple line removed and the margin submitted. 12. The specimen is labeled with the patient's name and as "final number 2 gastric and esophageal ring margin". It consists of 2 margins measuring 2.7 x 1.2 x 0.3 cm and 3.8 x 1 x 0.7-cm. The specimen is submitted in toto. 12A the smaller tissue sectioned(gastric) 12B-12C the longer(esophageal) Quick Section Diagnosis 5A, 5B. esophageal margin (en face): negative for carcinoma. 5C, 5D. representative sections of distal margin (en face): negative for carcinoma Time reported to surgeon: 101813
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diff --git a/output/text/a52ff414-2536-4477-81d3-0af2d4606105.txt b/output/text/a52ff414-2536-4477-81d3-0af2d4606105.txt
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index 0000000000000000000000000000000000000000..cdcf3181c68815207ca1c23e9162519bb1ecf613
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+M (159.0cm 60.4kg BSA: 1.63ma Accession: Specimen Date/Time: DIAGNOSIS ID-O 3 (A) LEFT NECK DISSECTION, LEVEL 1: Ten lymph nodes, negative for tumor (0/10)  Salivary gland, negative for tumor 8870[3 (B) LEFT NECK DISSECTION, LEVEL 2A: Sute: Oral cowuty CO69 Eighteen lymph nodes, negative for tumor (0/18) tO8/9/13 (C) LEFT NECK DISSECTION. LEVEL 3: Six lymph nodes, negative for tumor (0/6) (D)/ COMPOSITE RESECTION, LEFT PARTIAL MAXILLA TUBEROSITY, LEFT PARTIAL GLOSSECTOMY, LEFT SEGMENTAL  MANDIBULECTOMY, LEFT PARTIAL PHARYNGECTOMY: INVASIVE SQUAMOUS CARCINOMA -- Moderately differentiated Tumor Features:. Gross: Ulcerating. Size: 3.2 cm in largest dimension. Invasion: Present, depth 0.8 cm. Tumor Border: infiltrative with thick cords > 4 cells Perineural Invasion: Absent. Vascular Invasion: Absent Bone / Cartilage Invasion: Pending Decalcification (see addendum) (E) MEDIAL PTERYGOID PLATE: Skeletal muscle and fragment of bone, negative for tumor (F) LATERAL BUCCAL MUCOSAL MARGIN UUID:2A9E86E4-9782-4E8F-8FF4-FC31707A35C9 TCGA-CV-A63E-01A-PR  Squamous mucosa, negative for tumor Redacted (G) POSTERIOR ALVEOLAR MUCOSAL MARGIN: Squamous mucosa, negative for tumor (H) SOFT PALATE MUCOSAL MARGIN: Squamous mucosa, negative for tumor (I) LEFT MAXILLARY GINGIVA:  Squamous mucosa, negative for tumor GROSS DESCRIPTION (A) LEFT NECK DiSsEctION, LEVEL 1 - A 6.0 x 4.2 x 1.7 cm aggregate of fibroadipose tissue. The tissue is dissected to reveal six possible lymph nodes ranging from 0.5 x 0.2 x 0.2 cm -- 1.5 x 0.9 x 0.4 cm, and a 4.7 x 3.0 x 1.5 cm gland. Cut surfaces of the gland are tan, lobulated, and unremarkable. SECTION CODE: A1, A2. two possible lymph nodes in each; A3, one possible lymph node serially sectioned; A4, one possible lymph node, serially sectioned; A5, representative section of gland. (B) LEFT NECK DISSECTiON, LEVEL 2A - A 7.2 x 3.5 x 0.8 cm aggregate cf fibroadipose tissue. The tissue is dissected to reveal eighteen possible lymph nodes, ranging fram (0.2 x 0.2 x 0.2 cm - 1.1 x 0.9 x 0.7 cm) SECTiON cODE: B1, three possible lymph nodes; 82, four possible lymph nodes: B3-B5, three possible lymph nodes in
+
+--- Page 2 ---
+Page: 1159.0cm 60.4kc 89A: 1.63m Accesston: Specinen Date/rime: each; B6, one possible lymph node, serially sectioned; B7, one possible lymph node, serially sectioned. (C) LEFT NECK DISsECTION, LEVEL 3 --A (2.8 x 2.7 x 0.6 cm) aggregate of fibroadipose tissue. The tissue is dissected to reveal five possible lymph nodes, ranging from (0.3 x 0.3 x 0.2 cm - 0.7 x 0.5 x 0.3 cm) SECTION CODE: C1. C2, two possible lymph nodes in each; C3, one possible lymph node bisected. (D) COMPOSITE RESECTION LEFT PARTIAL MAXILLA TUBEROSITY, LEFT PARTIAL GLOSSECTOMY, LEFT SEGMENTAL MANDIBULECTOMY, LEFT PARTIAL PHARYNGECTOMY -- A composite section consisting of a segment of mandible with angle and condyles, posterior portion of pharynx, posterior maxillary tuberosity and medial portion of tongue with underlying skeletal muscle. The specimen measures 8 cm from anterior to posterior, 4.9 cm from lateral to medial and 4.6 cm from superior to inferior. The mucosal surface shows an ulcerated area (3.2 x 2.4 cm) which is located 0.4 cm from the lateral buccal margin, 0.7. cm from the medial tongue margin, 1.3 cm from the anterior soft tissue margin, and 1.7 cm from the posterior pharyngeal margin.. Cut surfaces show gray-white firm tissue underlying the ulcerated area, extending to a depth of 0.8 cm. The bone underlying this. ulcerated area shows fine pitting and deformity. Representative sections are submitted. The bone is submitted to the bone lab following decalcification and further sectioning.  SECTION CODE: D1, anterior soft tissue; D2-D9, representative serial sections from anterior to posterior including ulcer (D3-D4, D5-D6, D7-D8, one cross section each); D10, posterior pharyngeal soft tissue.  D11, anterior margin; D12, D13, pitted bone underlying ulcerated area; D11-D13, submitted for decalcification. (E) MEDIAL PTERyGOID PLATE -- A portion of bone with attached fibromuscular tissue (2.2 x 1.7 x 1 cm). Cut surfaces of the soft tissue are unremarkahle. The soft tissue is submitted in E1 and the bone is submitted to the bone lab for decaicification and further sectioning Representative section of the pterygoid plate submitted in E2 for decalcification. (F) LATERAL BUCCAL MUCOSAL MARGIN - A single strip of mucosa (3 x 0.5 x 0.2 cm). The specimen is submitted entirely for frozen section diagnosis in F. *FS/DX: NO TUmOr PrESENT (G) POSTERIOR ALVEOLAR MUCOSAL MARGIN - A single inked strip of soft tissue (2.5 x 0.4 x 0.4 cm). The specimen is submitted entirely ink side down for frozen section diagnosis in G. *FS/DX: NO TUMOR PRESENT. (H) SOFT PALATE MUCOSAL MARGIN - A single strip of mucosa (3.4 x 0.4 x 0.4 cm). The specimen is bisected and submitted entirely for frozen section diagnosis in H. *FS/DX: NO TUMOR PRESENT. (I) LEFT MAxILLARY GINGIVA - A single mucosa covered soft tissue (1 x 0.6 x 0.4 cm). The specimen is bisected and submitted entirely for frozen section diagnosis in I. *FS/DX: NO TUMOR PRESENT. CLINICAL HISTORY SNOMED CODES T-11180, T-11170. T-55000. T-53000. M-80703. M-43000, "Some tests reported here may have been developed and pertormance charact nave not been specitically cleared or approved by the U.S.Food and Drua Admnistration. tics determined by Entire report and diagnosis completed by: Start of ADDENDUM
+
+--- Page 3 ---
+Paye: 3 (03.0m 60.4kg 33A: 1.63m) Accession: Specimen Date/rime: ADDENDUM This modified report is being issued to provide additional information/results. Addendum completed by COMMENT Additional bone sections from part (D) of the mandible are negative for bone invasion. The anterior mandibular margin is also negative for carcinoma.  Bone section from part (E) medial pterygoid plate is negative for carcinoma. Entire report and diagnosis completed by: --END OF REPORT---
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diff --git a/output/text/a557bbbe-2480-431f-b059-9d1ed80d10de.txt b/output/text/a557bbbe-2480-431f-b059-9d1ed80d10de.txt
new file mode 100644
index 0000000000000000000000000000000000000000..38777cf49466731e8de32d5b37949598c62ad7cd
--- /dev/null
+++ b/output/text/a557bbbe-2480-431f-b059-9d1ed80d10de.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+tcD-o-3 CQrcincmo-,adrenol Cortial Oncocytic type . 8370/3 Site B Adrenal Gland,eortex 0 74.0 JtO i/3d13 UUID: 718C16E9-A099-4F21-A48E-A978464A9422 TCGA-OR-A5K3-01A-PR Redacted PROCEDURE: SPHS year-old with adrenal cancer presenting on. Nith fever, headache,. tinnitus and left sided flank pain. cT scan revealed a 15.8 x 16.1 cm adrenal mass with fatty inflammation and bordertine enlarged periaortic and paracaval lymphadenopathy. Clinical Diagnosis: Adrenal cancer. Operative Procedure: Left  nephrectomy. PRCCEDURE: SPGD 1. Labeled with patient's name and hospital registration number. Received in an extra large container. A 38 x 28 x 14 cm left adrenalectomy, splenectomy, distal pancreatectomy and nephrectomy specimen consisting of a 16 x 13 cm spleen and 8 cm portion of pancreas and a 9 cm kidney. Inked blue. There is a 16 x 15 x 14.5 cm sotid lobulated well-circumscribed orange-yellow adrena! inass with focal areas of necrosis (approximately 40-50% necrosis). The mass is 2.5 cm from the kidney, 4.5 cm from the spleen and is separated from the
+
+--- Page 2 ---
+ PREVIOUS DIAGNOSIS INQUIRY PAGE #: SEX:M BIRTHDATE: PAT TYPE: ADMDATE: OPER DATE: pancreas by a facial plane. Neither the spleen nor the kidney nor the pancreas appear to be grossly involved by neoplasm. Splenic vessels are not grossly involved. Renal vessel is not grossly involved by tumor. Ihe splenic parenchyma is tan, beefy red and grossly unremarkable with a smooth capsule. No abnormalities are seen within the pancreas or spleen. 1A-E. Adrenal mass. : 1f. Renal vessels. 1G. Grossly uninvolved kidney. 1H. Distal aspect of pancreas.. 11. Adrenal mass at kidney. 1J. Spleen. 1K-L. Tumor. PROCEDURE: SPDX 1. Adrenal gland, spleen, distal pancreatectomy and nephrectomy, composite. resection: Adrenal cortical carcinoma, oncocytic type, with minimal capsular invasion, 16 cm in greatest dimension, low-grade by mitotic activity. No. vascular invasion identified. Resection margins negative. Unremarkable. pancreas, spleen and kidney. See coMmEnt.. COMMENT : This cortical neoplasm does show signiticant areas of necrosis, and this. raises the possibitity, however untikely, that the necrotic neoplasm. represents high-grade carcinoma. Case discussed at examined and interpreted the slides from this case..
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diff --git a/output/text/a56037ab-2f0e-4f6e-85dd-4037add9880c.txt b/output/text/a56037ab-2f0e-4f6e-85dd-4037add9880c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9935b4829c3892918bbf121e20853a8f1496189a
--- /dev/null
+++ b/output/text/a56037ab-2f0e-4f6e-85dd-4037add9880c.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Catiome, nfiInating duct nos 85ocf3 TSs P4 Site ivsi. buest. uyy enps quadunte50.y CqcF Sih: brsst, Nos c50.9 10/29/0 TSS UUID:431AE1CB-9605-45E3-B6C3-5253B24655D6 l TCGA-E2-A1B1-01A-PR Redacted SPECIMENS: A. SENTINEL LYMPH NODE 1 B. SENTINEL LYMPH NODE 2 C. SENTINEL LYMPH NODE 3 D. SENTINEL LYMPH NODE 4 E. SENTINEL LYMPH NODE 5 F. SENTINEL LYMPH NODE 6 G. SENTINEL LYMPH NODE 7 H. WLE LEFT BREAST 1. ADDITIONAL MARGIN LEFT BREAST DIAGNOSIS: SENTINEL LYMPH NODE, #1, EXCISION (PART A) - FRAGMENT OF FIBROADIPOSE TISSUE, NEGATIVE FOR MALIGNANCY, NEGATIVE FOR LYMPHOID TISSUE. SENTINEL LYMPH NODE #2, EXCISION (PART B) - METASTATIC DUCTAL CARCINOMA (4 MM IN DIAMETER, FOCAL EXTRACAPSULAR EXTENSION). SEE COMMENT. SENTINEL LYMPH NODES, #3-#7, EXCISION (PARTS C-G) - FIVE LYMPH NODES, NEGATIVE FOR MALIGNANCY (0/5). LEFI.BREAST, WIDE LOCAL EXCISION (PART H) - WELL DIFFERENTIATED INFILTRATING DUCTAL CARCINOMA, WITH A MUCINOUS COMPONENT (3.7 CM IN GREATEST DIAMETER, SBR GRADE I), - SEE COMMENT. - SURGICAL MARGINS OF EXCISION, NEGATIVE FOR MALIGNANCY. LEFT BREAST, ADDITIONAL MARGIN, EXCISION (PART i) - FIBROGLANDULAR BREAST TISSUE, NEGATIVE FOR MALIGNANCY. SPECIMEN(S): A. SENTINEL LYMPH NODE 1 B. SENTINEL LYMPH NODE 2 C. SENTINEL LYMPH NODE 3 D. SENTINEL LYMPH NODE 4 E. SENTINEL LYMPH NODE 5 F. SENTINEL LYMPH NODE 6 G. SENTINEL LYMPH NODE 7 H. WLE LEFT BREAST I. ADDITIONAL MARGIN LEFT BREAST CLINICAL HISTORY: /r old white female abnormal mammogram left upper outer breast. Cone Biopsy shows well differentiated infiltrating ductal carcinoma with mucinous features. ER+, Pr+ HER2+ by FISH Right breast MRI showed mass at left upper outer quadrant 3x3x0.8cm. Second enhancing mass at posterior aspect 7mm measurement. Questionable satellite lesion. INTRAOPERATIVE CONSULTATION DIAGNOSIS:E TPA, TPB: Lymph nodes, left axillary sentine! 1 & 2, excision: No malignancy identified, specimen A is predominantly fat. TPC, TPD: Lymph nodes, left axillary sentinel 3 & 4, excision: No malignancy identified.. TPE, TPF, TPG: Lvmoh nodes, left axillary sentinel 5, 6 & 7, excision: No malignancy identified. By Dr. called in at and GROSS DESCRIPTION: A. SENTINEL LYMPH NODE 1: - Received fresh for touch-prep and labeled, Sentinel Lymph Node #1, Left" is a piece of adipose tissue measuring 2.4x2x.4cm. It is bisected and a touch-prep is performed. Specimen is submitted in toto in block A1. B. SENTINEL LYMPH NODE 2:
+
+--- Page 2 ---
+tss: - Received in formalin and labeled *Sentinel Lymph Node #2, Left Axilla" is a lymph node with fat measuring 2x3.5x1.1cm. Bisected. A touch-prep is performed and lymph node is submitted in toto in block B1. C. SENTINEL LYMPH NODE 3: - Received in formalin and labeled Sentinel Lymph Node #3, Left Axilla" is a tan lymph node measuring 1.3x1.2x0.6cm. Bisected and a touch-prep is performed. Submitted in toto in block C1 D. SENTINEL LYMPH NODE 4: - Received fresh for touch-prep and labeled, Sentinel Lymph Node #4, Left Axilla" is a piece of yellow- tan fat and a tan lymph node measuring 1.5x1.2x0.3cm. It is bisected and a touch-prep is performed. Specimen is submitted in toto in block D1. E. SENTINEL LYMPH NODE 5: - Received fresh for touch-prep and labeled, Sentinel Lymph Node #5, Left Axilla" is a piece of fat and a tan lymph node measuring 2.3x1.5x0.7cm. The specimen is serially sectioned and touch-prep is performed. Lymph node is submitted in toto in block E1-E2. F.  SENTINEL LYMPH NODE 6: - Received fresh for touch-prep and labeled, Sentinel Lymph Node #6, Left Axilla" is a piece of yellow- tan adipose tissue containing a lymph node measuring 1.5x0.7x0.5cm. The lymph node is bisected and a touch-prep is performed. The lymph node is submitted in toto in block F1. G. SENTINEL LYMPH NODE 7: - Received fresh for touch-prep and labeled, Sentinel Lymph Node #7, Left Axilla" is a piece of yellow- tan fat containing a lymph node measuring 1.0x9.0x4cm. It is bisectioned and a touch-prep is performed. Specimen is submitted in toto in block G1. H. WLE LEFT BREAST - Received fresh and labeled, Wide Local Excision, Left Breast with Needle Localization" is an ova! shaped piece of yellow-tan fibrofatty soft tissue weighing 161 grams and measuring 9.2x8.1x3.2cm. The specimen is received with an accompanying radiogram which shows a needie coursing from the  medial aspect to the lateral aspect. The needle is a stellate area of increased density and a surgical clip is present. The specimen has been oriented in surgery with short designating superior long lateral and looped anterior. Specimen is inked as follows: inferior-orange, superior-red, lateral-yellow, anterior-blue, medial-green and posterior black. Specimen is serially sectioned from superior to inferior and in the inferior aspect of the specimen is an irregularly shaped firm pink-tan mass measuring 3.7x3.5x1.5cm. Areas of hemorrhage are seen. The mass is within 1.1cm from the lateral margin, 1.2cm from the anterior margin, 2.2cm from the medial margin, 1.7cm from the deep margin, 1.7cm from the inferior margin and approximately 4.4cm from the superior margin. Superior and slightly posterior from this mass is a firm tan nodule measuring 0.7cm which is located 0.8cm from the larger mass. It is possible that it is a continuous mass located 1.2cm from the lateral margin, 3.7cm from the anterior margin, 1.3cm from the posterior margin and 4.8cm from the medial margin. This mass corresponds with the increased area of density and second needle localization which is present on the radiogram which is shown superior to the larger mass. Representative sections are submitted as follows: H1-H6 larger mass including adjacent margins; H7-H8 breast tissue between larger mass and smaller mass; H9 smaller mass; H10-H13 additional fibrous breast tissue; H14 superior margin; H15 inferior margin. I. ADDITIONAL MARGIN LEFT BREAST: - Received in formalin and labeled , Additional Margin Left Breast. This Marks New Inferior Margin" is an irregularly shaped piece of yellow-tan fibrofatty breast tissue measuring 4.7x4.7x0.8cm. There is a stitch present marking the new inferior margin. The margin is inked blue and serially sectioned. On sectioning little fibrous tissue is seen and no masses or lesions are found. Specimen is submitted in toto in blocks I1-110. COMMENT: Review of the original touch prep, for sentinel lymph node #2, shows a single minute focus of metastatic tumor cells. The metastatic deposit in sentinel lymph node #2 measures 4mm in greatest diameter, and shows approximately 1mm of extracapsular extension focally. Gross examination of the left breast wide local excision shows an irregularly shaped 3.7x3.5x1.5cm lesion, which is grossly away from the
+
+--- Page 3 ---
+TSS: : margins of excision. On gross examination, there is a separate firm nodule which measures 0.7cm in. diameter which is near the larger tumor mass. Examination of microscopic sections, in the intervening. breast between these two nodules, however shows continuity of the 2nd smaller noduie with the larger mass, consistent with an irregular, dumbbell shaped single lesion. This patient had ER, PR and HER2. IHC performed on her prior needle core biopsy (). These results were ER positive, PR positive and. HER2 was found to be amplified by FISH. Specimens Involved Specimens: H: WLE LEFT BREAST BREAST CANCER TEMPLATE Specimen Type: Excision Needle Localization:. Yes Laterality: ( Left) Invasive tumor: Present Multifocality: No Specimen size: Size of Invasive focus 3.7cm Additional dimensions: 3.5cm x 1.5cm Tumor Site: Upper outer quadrant) Margins: Negative Distance from closest margin: 0.4cm. Margin: anterior Tubular score: 1 (>75% tubule) Mitotic score (Olympus 40x):1 (0-6/10 hpf) Modified Scarff Bloom Richardson Grade:. I (3-5 points) Necrosis: Absent Vascular/Lymphatic Invasion:  None identified Lobular neoplasia: None Nuclear score: 2 Lymph nodes: Sentinel lymph node only Lymph node status: Positive 1 / 6 Extranodal extension. DCIS PRESENT? No Pathological staging (pTN): pT 2 N 1 Microscopic/Diagnostic Dictation: Pathologist, Microscopic/Diagnostic Dictation: PATHOLOGIST, Final Review: PATHOLOGIST Final Review: PATHOLOGIST. Final:PATHOLOGIST,
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diff --git a/output/text/a57e77fc-43b1-47cf-b4a5-c07da0b7d2ee.txt b/output/text/a57e77fc-43b1-47cf-b4a5-c07da0b7d2ee.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f750c1166dc69b81f7743cc0dbadadce706b03ba
--- /dev/null
+++ b/output/text/a57e77fc-43b1-47cf-b4a5-c07da0b7d2ee.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis: This is a poorly differentiated adenocarcinoma of the sigmoid colon of histopathological differentiation grade G3, with erosions of the inner tumor surface, with peritumorous chronic recurrent secondary inflammation with an acute inflammatory flare, with tumor infiltration of the colon wall layers as far as the pericolic fatty connective tissue, with carcinomatous lymphangitis, with tumor-free lymph nodes (0/16) with moderate chronic lymphadenitis and tumor-free overview slices from all other parts of the resection material described. According to the section preparations available, the tumor spread of the sigmoid carcinoma corresponds to the tumor stage pT3, pN0 (0/16), MX, L1, R0 with regard to the so-called radial resection margin, this shows a mature, predominantly fatty connective tissue, with regard to the lymph nodes, these show a metastasis (1 of 13) of the carcinoma described. Summary tumor classification: ICDO-DA M-8140/3 G3
\ No newline at end of file
diff --git a/output/text/a589acb3-4446-4d53-bab3-0dd65b4d714c.txt b/output/text/a589acb3-4446-4d53-bab3-0dd65b4d714c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c652ae39b6b91f66c8dfcf1155113e3ac1c66132
--- /dev/null
+++ b/output/text/a589acb3-4446-4d53-bab3-0dd65b4d714c.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SPECIMENS: A. RIGHT COLON SPECIMEN(S):  A. RIGHT COLON INTRAOPERATIVE CONSULTATION DIAGNOSIS: A-right colon: Tumor is 11 cm from each margin (proximal and distal) called by GROSS DESCRIPTION:I A. RIGHT COLON Received fresh is a closed segment of colon including terminal ileum, ileocecal valve, cecum, and colon measuring 25 cm in length. The serosa has an area of tattooing approximately 7 cm from the distal margin. The vermiform appendix is 7.1 cm in length and 0.5 cm in width; it is unremarkable. On opening the colon, the segment of terminal ileum is 6 cm in length and 4 cm in diameter; right colon is 19 cm in length and up to 10 cm in diameter. The colon contains a circumferential, polypoid, indurated, mass with serpentine borders measuring 6 x 4.3 cm extending through the muscularis propria. The mass is located 11 cm from the proximal and distal margins and 5 cm from ileocecal valve. There are 2 colonic polyps, 0.5 and 0.6 cm. Tissue is procured. Representative sections are submitted as follows: A1: proximal margin A2: distal margin A3-A8: mass in relationship with normal mucosal and deep margin A9: colonic polyps A10: normal-appearing mucosa including region of tattooing. A11: appendix A12: proximal, 6 lymph nodes A13: proximal, 2 lymph nodes A14-A15: proximal, 1 node each A16-A23: distal, 6 lymph nodes each A24-A25: distal, 3 lymph nodes each A26-A27: distal, 2 lymph nodes each A28-A33: distal, 1 lymph node each A34-A36: 7 possible lymph nodes each (after O-Fix) DIAGNOSIS: COLON, RIGHT, HEMICOLECTOMY:  INVASIVE ADENOCARCINOMA, MODERATELY DIFFERENTIATED, ARISING IN A TUBULOVILLOUS ADENOMA.  TUMOR MEASURES 6 CM. - TUMOR INVOLVES THE SUBSEROSAL FAT. - MARGINS, FREE OF TUMOR - HYPERPLASTIC POLYPS (2). - APPENDIX, NO TUMOR SEEN. - METASTATIC CARCINOMA TO TWO OF 65 LYMPH NODES WITH FOCAL EXTRANODAL EXTENSION (2/65). SYNOPTIC REPORT - COLON & RECTUM Specimen Type:  Right hemicolectomy Tumor Site: Hepatic flexure Tumor Configuration: Infiltrative Ulcerating Tumor size: 6cm WHO Classification Adenocarcinoma 8140/3 Histologic Grade: G2: Moderately differentiated Extent of Invasion: Subserosa Margins: Margin(s) uninvolved by invasive carcinoma (Proximal, Distal, Radial) Venous/Lymphatic Invasion:  Present Perineural Invasion: Absent Additional Pathologic Findings: Adenoma Extent of Resection:  R0: Complete resection with grossly and microscopically negative margins
+
+--- Page 2 ---
+Lymph Nodes: Positive 2 / 65 Extranodal extension: Present Implants: Absent Pathological Staging (pTNM):  pT 3 N 1 M X CLINICAL HISTORY:  None given PRE-OPERATIVE DIAGNOSIS:I  Colon cancer
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diff --git a/output/text/a58d0505-dcbd-47ce-964b-4d3d1575fff2.txt b/output/text/a58d0505-dcbd-47ce-964b-4d3d1575fff2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..509bb68288bb699fe3528b201752371db6a49984
--- /dev/null
+++ b/output/text/a58d0505-dcbd-47ce-964b-4d3d1575fff2.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+Page 1 of 6 UUID:71F04D3B-0CA3-4CB3-9E94-E082F37C4097 TCGA-XF-A9T2-01A-PR Redacted DIAGNOSIS: RADICAL CYSTECTOMY, BILATERAL PELVIC LYMPH NODES DISSECTIONS TCD b3 RIGHT DISTAL URETER (A) : FROZEN SECTION DIAGNOSIS: - NEGATIVE 812013 FINAL DIAGNOSIS: OLLE BENIGN URETER NO DYSPLASIA OR CARCINOMA IDENTIFIED Q679 LEFT DISTAL URETER (B): Wsdder, Lotra! wall. FROZEN SECTION DIAGNOSIS: C6z.2 - FOCAL HIGH GRADE DYSPLASIA FINAL DIAGNOSIS: RO b|261)y BENIGN URETER ON PERMANENT SECTION  NO DYSPLASIA OR CARCINOMA IDENTIFIED MARGIN #2, LEFT URETER (C) : FROZEN SECTION DIAGNOSIS:  NEGATIVE FINAL DIAGNOSIS: BENIGN URETER NO DYSPLASIA OR CARCINOMA IDENTIFIED APICAL URETHRAL MARGIN F/S: INTRAOPERATIVE FROZEN SECTION DIAGNOSIS: NEGATIVE FINAL DIAGNOSIS: - BENIGN URETHRAL MUCOSA - NO HIGH GRADE DYSPLASIA OR CARCINOMA IDENTIFIED BLADDER/PROSTATE (E): INTRAOPERATIVE GROSS DIAGNOSIS:  TUMOR IDENTIFIED IN LEFT BLADDER WALL INFILTRATING THROUGH MUSCULAR PROPRIA TO THE PERIVESICAL SOFT TISSUE FINAL DIAGNOSIS: BLADDER : POORLY DIFFERENTIATED UROTHELIAL CARCINOMA, NUCLEAR GRADE 4/4, INFILTRATING THROUGH THE MUSCULARIS PROPRIA INTO PERIVESICAL FAT, BUT NOT AT THE INKED MARGINS (SEE COMMENT) - LYMPHOVASCULAR INVASION IDENTIFIED - NO UROTHELIAL CARCINOMA IN SITU (FLAT LESION IDENTIFIED) IDENTIFIED ALL SURGICAL MARGINS FREE OF MALIGNANCY PROSTATE: BILATERAL PROSTATIC ADENOCARCINOMA, GLEASON'S SCORE 6 (3+3)) CONFINED TO THE PROSTATE WITH FOCAL ABUTTING AT THE RIGHT APICAL MARGIN (<2%) - THE REMAINING APICAL AND PERIPHERAL PROSTATIC MARGINS, FREE OFS MALIGNANCY - BILATERAL SEMINAL VESICLES AND VASA DIFFERENTIA, FREE OFS MALIGNANCY - MULTIFOCAL HIGH GRADE PROSTATIC INTRAEPITHELIAL NEOPLASIA (PIN II-III)S - PROSTATIC ATROPHY WITH FOCAL CHRONIC INFLAMMATION IDENTIFIED RIGHT PARACAVAL LYMPH NODES (F) - NO METASTATIC CARCINOMA IDENTIFIED IN 1S LYMPH NODES EXAMINED (O/15)) RIGHT COMMON ILIAC LYMPH NODES (G) :
+
+--- Page 2 ---
+Page 2 of 6 erdereor NO METASTATIC CARCINOMA IDENTIFIED IN SEVEN LYMPH NODES EXAMINED (O/7) RIGHT PRESACRAL LYMPH NODES (H) : - NO METASTATIC CARCINOMA IDENTIFIED IN FOUR LYMPH NODES EXAMINED (O/4) RIGHT LYMPH NODES OF CLOQUET (I) : - NO METASTATIC CARCINOMA IDENTIFIED IN THREE LYMPH NODES EXAMINED (O/3) RIGHT EXTERNAL ILIAC LYMPH NODES (J) : - NO METASTATIC CARCINOMA IDENTIFIED IN 18 LYMPH NODES 0/18) RIGHT OBTURATOR/HYPOGASTRIC LYMPH NODES (K) : - NO METASTATIC CARCINOMA IDENTIFIED IN SEVEN LYMPH NODES EXAMINED (O/7) LEFT .PARA AORTIC LYMPH NODES (L): - NO METASTATIC CARCINOMA IDENTIFIED IN NINE LYMPH NODES EXAMINED (O/9) LEFT COMMON ILIAC LYMPH NODES (M) : - NO METASTATIC CARCINOMA IDENTIFIED IN 19 LYMPH NODES EXAMINED (0/19) LEFT LYMPH NODES OF CLOQUET (N) : - NO METASTATIC CARCINOMA IDENTIFIED IN FIVE LYMPH NODES EXAMINED (O/5) LEFT EXTERNAL ILIAC LYMPH NODES (O) : - NO METASTATIC CARCINOMA IDENTIFIED IN 22 LYMPH NODES EXAMINED (0/22) LEFT OBTURATOR/HYPOGASTRIC LYMPH NODES (P) : - NO METASTATIC CARCINOMA IDENTIFIED IN 18 LYMPH NODES EXAMINED (0/18) LEFT PRE SCIATIC LYMPH NODES (Q): NO METASTATIC CARCINOMA IDENTIFIED IN NINE LYMPH NODES EXAMINED (O/9) RIGHT PRE SCIATIC LYMPH NODES (R) : - NO METASTATIC CARCINOMA IDENTIFIED IN FIVE LYMPH NODES EXAMINED (0/5) LEFT PROXIMAL URETER (S): BENIGN URETER - NO DYSPLASIA OR CARCINOMA IDENTIFIED RIGHT PROXIMAL URETER (T) : -BENIGN URETER - NO DYSPLASIA OR CARCINOMA IDENTIFIED TOTAL LYMPH NODES: - NO METASTATIC CARCINOMA IDENTIFIED IN 141 LYMPH NODES EXAMINED (O/141) AJCC PATHOLOGIC STAGE (STH EDITION) : T3bNOMX COMMENT: Immunohistochemical studies for chromogranin and synaptophysin are negative, which indicates there is no neuroendocrine differentiation of the bladder carcinoma. The
+
+--- Page 3 ---
+Page 3 of 6 HTosaton case was discussed with SPECIMEN SOURCE: A: "Right distal ureter" B: "Lt. distal ureter" C: "Margin #2 left ureter" D: "Apical urethral margin-f/s" E: "Bladder/prostate" F: "Rt. para caval L.N." G: "Rt. common iliac L.N." H: "pre sacral L.N." I: "Rt. L.N. of cloquet" J: "Rt. external iliac L.N." K: "Rt. obturator/hypogastric L.N." L: "Left para aortic L.N." M: "Lt. common iliac L.N." N: "Lt. L.N. of cloquet" 0: "Lt. external iliac' L.N." p: "Lt.  obturator/hypogastric L.N." Q: "Lt. I pre sciatic L.N.# R: "Rt. pre sciatic L.N." s: "Lt. proximal ureter" T: "Rt. proximal ureter" CLINICAL INFORMATION:S Pre-op Dx: Invasive bladder cancer. Post-op Dx: Same GROSS EXAMINATION: A: The specimen is received fresh from the o.R. and labeled "Right distal ureter". It consists of a segment of ureter measuring 0.2 cm in length x 0.3 cm in diameter. The specimen is entirely submitted for frozen section in AFs. B: The specimen is received fresh from the O.R. and labeled "Lt. distal ureter". It consists of a segment of ureter measuring 0.2 cm in length x 0.3 cm in diameter. The specimen is entirely submitted for frozen section in BFs. C: The specimen is received fresh from the O.R. and labeled "Margin #2 left ureter". ~It consists of a segment of ureter measuring 1 cm in length x 0.4 cm in diameter.  The specimen is oriented by the surgeon and the club is both at the distal end.  The distal end is kept for permanent and the proximal margin is submitted for frozen section in cFs, and the remaining tissue is submitted in one cassette. D:  The specimen is received fresh from the O.R. and labeled "Apical urethral margin-f/s. It consists of red-tan soft tissue fragment measuring 2.5 x 0.5 x 0.2 cm. The specimen is entirely submitted for frozen section in DFs. E: The specimen is received fresh from the O.R. and labeled "Bladder/prostate". It consists of a radical prostatectomy specimen weighing 422 grams and measuring overall 25 x 12 x 6 cm. The peritoneum measures 19 x 15 x 0.1 cm. It is yellow-pink smooth glistening and unremarkable.  The prostate and the lower bladder are entirely inked black. Red ink is superimposed on the right side of prostate. The prostate measures 5.5 x 4.5 x 4 cm. Opening the prostate anteriorly reveals the prostatic urethra to measure 4 cm in length x 3 cm in circumference without excavation.  The verumontanum measures 0.7 x 0.5 x 0.3 cm and is unremarkable. The bladder itself measures 6 x 5 x 4 cm.  Opening the bladder anteriorly shows an exophytic tumor on the left lateral wall which measures 5.5 x 5 x 4 cm. The tumor extends grossly through the muscle and abut the inked peritoneal margin. The tumor comes within 0.2 cm from the left ureterovesical junction. The attached right
+
+--- Page 4 ---
+Page 4 of 6 ureter measures 5 cm in length x 0.5 cm in diameter with normal appearing mucosa The attached left ureter measures 4 cm in length x 0.5 cm in diameter with normal appearing mucosa.  The right seminal vesicle measures 3 x 2 x 0.5, and the left seminal vesicle measure 2.5 x 2 x 0.7 cm and are grossly unremarkable. The right vas deferens measures 3 cm in length x 0.5 cm in diameter and the left vas deferens measures 3.5 cm in length x 0.5 cm in diameter, and are grossly unremarkable. Representative sections are submitted in 34 cassettes. F: The specimen is received in formalin and labeled "Rt. para caval L.N.". It consists of an aggregate of yellow fatty tissue with probable lymph nodes measuring 3.2.5 x0.5 cm.  The specimen is entirely submitted in two cassettes. G: The specimen is received in formalin and labeled "Rt. common iliac L.N.". It consists of an aggregate of fibrofatty tissue measuring in aggregate 3.5 x 2.5 x 1 cm.  The specimen is entirely submitted in three cassettes. H: The specimen is received in formalin and labeled "pre sacral L.N.". It consists of fibro_ tissue fragment measuring 4 x 3 x 2 cm. The specimen is entirely submitted in three cassettes. I: The specimen is received in formalin and labeled "Rt. L.N. of cloquet". It consists of lymph node with surrounding fat measuring 1.5 x.1 x 0.5 cm. The specimen is bisected and entirely submitted in one cassette. J: The specimen is received in formalin and labeled "Rt. external iliac L.N.". It consists of multiple fragments of yellow fatty tissue with lymph nodes measuring in aggregate 6.5 x 3.8 x 2.1 cm. The specimen is entirely submitted in six cassettes.  The specimen is received in formalin and labeled "Rt. obturator/hypogastric K L.N.". It consists of multiple fragments of yellow fatty tissue with lymph nodes measuring in aggregate 7 x 5.5 x 2.5 cm. The specimen is entirely submitted in seven cassettes. L:  The specimen is received in formalin and labeled "Left para aortic L.N.". It consists of multiple fragments of yellow fatty tissue with lymph nodes measuring in aggregate 4.5 x 3.5 x 1.5 cm. The specimen is entirely submitted in three M:  The specimen is received in formalin and labeled "Lt. common iliac L.N.". It consists of multiple fragments of yellow fatty tissue with lymph nodes measuring in aggregate 6.5 x 4 x 2.5 cm. The specimen is entirely submitted in six cassettes. N: The specimen is received in formalin and labeled "Lt. L.N. of cloquet". It consists of one lymph node measuring 2 x 1.5 x 1 cm. The lymph node is. serially sectioned and entirely submitted in two cassettes.. O: The specimen is received in formalin and labeled "Lt. external iliac L.N.". It consists of multiple fragments of yellow fatty tissue with lymph nodes measuring in aggregate 6.5 x 4 x 2 cm. The specimen is entirely submitted in six cassettes. P: The specimen is received in formalin and labeled "Lt. obturator/hypogastric L.N.". It consists of multiple fragments of yellow fatty tissue with lymph nodes measuring in aggregate 9 x 6 x 3 cm. The specimen is entirely. submitted in eight Cassettes. Q: The specimen is received in formalin and labeled "Lt. pre sciatic L.N.". It consists of multiple fragments of yellow fatty tissue measuring in aggregate 1.5 x 1 x 0.5 cm. The specimen is entirely submitted in one cassette. R The specimen is received in formalin and labeled "Rt. pre sciatic L.N.". It
+
+--- Page 5 ---
+Page 5of 6 OrderedFov consists of multiple fragments of yellow fatty tissue measuring in aggregate. 2 x 1 cm. The specimen is entirely submitted in two cassettes.. S The specimen is received in formalin and labeled "Lt. proximal ureter". It consists of a segment of ureter measuring 1 cm in length x 0.5 cm in diameter.. The specimen is serially sectioned and entirely submitted in one cassette. T:  The specimen is received in formalin and labeled sRt. proximal ureter".. It consists of a segment of ureter measuring 0.6 cm in length x 0.5 cm in diameter. The specimen is serially sectioned and totally submitted in one cassette.. SECTIONS: AFS: frozen section, right distal ureter BFS: frozen section, left distal ureter ces: frozen section, margin # 2 left ureter; proximal. margin. C1: remaining tissue DFS: apical urethral margin E1, 2: consecutive section of tumor E3: tumor with deep inked margin E4: tumor with left ureterovesical junction. E5-7:  tumor with deep inked margin E8-9: consecutive section of tumor E10: tumor with deep inked margin E11: representative section of left anterior wall. E12: representative section of dome E13: representative section of right  anterior wall E14: representative section of posterior wall E15: right ureterovesical junction E16: representative section of trigone E17, 18: right apex of prostate E19,  20: left apex of prostate. E21: right anterior distal prostate E22 : right posterior distal prostate E23 : left distal prostate. E24 : right anterior mid prostate E25: right posterior mid prostate E26 : left anterior mid prostate E27: left posterior mid prostate E28: right anterior proximal prostate E29: right posterior proximal prostate E30: left anterior proximal prostate E31: left posterior proximal prostate with left seminal vesicle and prostate. junction E32 : right seminal vesicle and right vas deferens. E33 : left seminal vesicle and left vas deferens. E34 : fat for probable lymph node F1-2: right para caval lymph node G1-3: right common iliac lymph node H1-3: pre sacral lymph node. I: right lymph node of Cloquet, bisected J1-6: right external iliac lymph node K1-7: right obturator/hypogastric lymph node L1-3: left para aortic lymph node M1-6: left common iliac iymph node N1, 2: left lymph node of cloquet 01-6: left external iliac lymph node P1-6: left obturator/hypogastric lymph node Q: left pre sciatic lymph node R1 2 : right pre sciatic lymph node s: left proximal ureter
+
+--- Page 6 ---
+Page 6 of 6 T1 right proxima. ureter INTRAOPERATIVE FROZEN CONSULTATION: AFs: Right distal ureter negative bes: Left distal ureter focal high-grade dysplasia CFS: Margin #2 left ureter  negative DFS: Apical. urethral margin negative INTRAOPERATIVE GROSS CONSULTATION Bladder (E)  tumor identified which involves the muscle and abuts the inked margin MICROSCOPIC EXAMINATION A-T. See final microscopic diagnosis. A
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diff --git a/output/text/a5b51444-7fee-424c-a947-5a5ff8c228db.txt b/output/text/a5b51444-7fee-424c-a947-5a5ff8c228db.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5c50bca89be66e29884d337cce566d849fa57cfe
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+/cs-0-3 carciomn infiltratng ouct,Nos 850/3 Sit, breust, Nos C5o.9 p #/7/11 Procurement Date Laterality:Right, upper inner quadrant Path Report:BREAST TISSUE CHECKLIST Specimen type: Radical mastectomy Specimen size: Not specified Tumor site: Breast Tumor size: 3.5 x 3.5 x 3.5 cm Grossly evident lesion: Yes Histologic type: infiltrating ductal carcinoma. Histologic grade: Moderately differentiated. Tumor extent: Not specified Lymph nodes: 4/10 positive for metastasis (Axillary 4/10) Extracapsular invasion of the lymph nodes: Not specified Margins: Not specified Nottingham Histologic Score Tubule formation: Not specified UUID:7788E7FD-B5A3-4B22-83CA-EA3F85E826FC TCGA-E9-A22E-01A-PR Nuclear pleomorphism: Not specified Redacted Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined. Evidence of neo-adjuvant treatment: Not specified. Additional pathologic findings: Not specified. Comments: None
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diff --git a/output/text/a5d19f9c-38b2-4454-ba7d-fd2a318d0a02.txt b/output/text/a5d19f9c-38b2-4454-ba7d-fd2a318d0a02.txt
new file mode 100644
index 0000000000000000000000000000000000000000..05619c06f42d93d91828329a1cdaaaf756afa336
--- /dev/null
+++ b/output/text/a5d19f9c-38b2-4454-ba7d-fd2a318d0a02.txt
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+
+--- Page 1 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA  SURGICAL PATHOLOGY REPORT Patient: Specimen #: FMP/SSN: DOb/Age/Sex (Age: )F Race: WHITE Taken: Location: Received: Physician(s) : Reported: **AMENDED / ADDENDUM** 1CD-0-3 Casnona, nifiItrat'ng lobv/es, nos SPECIMEN: RIGHT BREAST TISSUE 8520/3 Sit: brast, Nos c50.9 FINAL DIAGNOSIS: BREAST, RIGHT INFERIOR LATERAL RETRO-AREOLA, EXCISION: INFILTRATING LOBULAR...CARCINOMA. SURGICAL MARGINS POSITIVE FOR TUMOR. TUMOR SIZE: O.5 CM BY MICROSCOPY. LOBULAR CARCINOMA IN SITU. PERINEURAL INVOLVEMENT BY CARCINOMA. MICROCALFICIATIONS IDENTIFIED. AJCC STAGING: STAGE I (T1, NX, MX), SEE COMMENT. COMMENT : (visiting pathology resident from. discussed the above diagnosis with Dr. on : at AMENDMENT At the request of the clinician, tumor was evaluated for Her2-neu overexpression by immunohistochemical methods (DAko HercepTest) with the following results: HER2/neu overexpression: NEgATIvE (1+). cOMmeNT: Membranous staining is interpreted on a scale of 0 to 3+ with positivity defined as 2+ or qreater.: Test performed at Interpretation rendered oy. ** Report Electronically Signed Out * UUID:B065FC65-CD33-4878-AE2C-7E8C04FSECAB TCGA-A2-A0CK-01A-PR Redacted Page 1 Continued on Next Page. FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 2 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 -5 SURGICAL PATHOLOGY REPORT Patient: Specimen #: ADDENDUM: HER2/NEU BY FISH = 1.1 NOT AMPLIFIED TEsT: FIsh for detection of HER2-neu gene amplification (Path Vision Her2 DNA probe by Vysis). Ratio of Her2-neu over chromosome 17 signals. RANGE FOR INTERPRETATION: Ratio less than 2.0: Her2-neu gene amplification not observed. Ratio equal to or greater than 2.0: HEr2-neu gene amplification observed. ER/PR IMMUNOSTAINS ARE NEGATIVE. CI INICAL DIAGNOSIS AND HISTORY: YO FEMALE WITH SMALL 1X.6CM COMPLEX MASS BY U/S AT INFERIOR/LATERAL RETROAREOLAR PRE-OPERATIVE DIAGNOSIS: FIBROUS TISSUE VS MALIGNANCY POST-OPERATIVE DIAGNOSIS: Post-operative Diagnosis: SAA GROSS DESCRIpTION: RIghT BReAsT TIssuE "inferior lateral retro-areola" consists of a single irregularly shaped fragment of fibro fatty tissue, which previously has been inked and sectioned. When reapproximated, the specimen measures 2 x 1 x 1 cm. The previous sectioning reveals that the specimen is mostly fat with admixed fibrous tissue.  The specimen is placed in its entirety. in the 5 gray cassettes marked Al-A5. The specimen was previously. inked blue before being received by this observer. Page 2 End of Report. FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974E
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diff --git a/output/text/a5f1251d-e889-4327-be1f-28a10597cd35.txt b/output/text/a5f1251d-e889-4327-be1f-28a10597cd35.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3a903782761015bf3b669d3a4d5f676436ff29f7
--- /dev/null
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+
+--- Page 1 ---
+1cs-0 -3 Cavcnoma, iifltratinq duct, NOS 85003 128/10 Sisu lnu. 5reu+N^0s c50.9 UUID: 2BAC50DA-016F-485C-B8D1-DE75377EF0C7 TcGA-E2-A15k-01a-pr Redacted TSS: SPECIMENS: A. RIGHT BREAST LUMPECTOMY B. RIGHT AXILLARY CONTENTS LEVELS 1,2 C. ADDITIONAL RIGHT AXILLARY TISSUE SPECIMEN(S): A. RIGHT BREAST LUMPECTOMY B. RIGHT AXILLARY CONTENTS LEVELS 1,2 C. ADDITIONAL RIGHT AXILLARY TISSUE GROSS DESCRIPTION: A. RIGHT BREAST LUMPECTOMY Received fresh labeled with the patient's identification and "right breast lumpectomy" is a previously inked, oriented 97g, 8 x 6.5 x 4.5cm lumpectomy. ink code: anterior-yellow, posterior-black, superior-blue, inferior-orange, medial-  green, lateral-red. Specimen is serially sectioned from lateral to medial into 8 slices revealing a 2 x 1.8 x 1.6cm tan white stellate mass, 0.6cm from the closest inferior margin in slices 2-5cm. A portion of the specimen is submitted for tissue procurement. Representatively submitted: A1: lateral margin slice 1 A2-A4: slice 2 with mass in A4 A5-A7: slice 3 with mass in A6. A8-A11: slice 4 A12-A15: slice 5 with mass in A15 A16-A17: slice 6 A18-A19: slice 7 A20: medial margin slice 8 B. RIGHT AXILLARY CONTENTS LEVELS 1,2 Received fresh is a tan pink soft tissue fragment 15 x 12 x 4cm. Dissection reveals 14 lymph nodes ranging from 0.3 x 0.3 x 0.2cm to 5 x 3.2 x 1.5cm. The largest lymph node is sectioned to reveal a firm homogenous white cut surface. B1: 5 lymph nodes. B2: 4 lymph nodes B3: 2 lymph nodes B4: 1 lymph node B5: 1 lymph node B6: 1 lymph node B7: 1 lymph node B8: 1 lymph node B9-B10: 1 lymph node B11-B12: 1 lymph node B13-B16: representative sections of 1 lymph node C. ADDITIONAL RIGHT AXILLARY TISSUE Received fresh is a tan pink soft tissue fragment 4.3 x 2.7 x 2cm. Dissection reveals a possible necrotic lymph node 2.8 x 1.3 x 1cm. Representatively submitted in C1-C4. DIAGNOSIS: A. BREAST, RIGHT, WIDE LOCAL EXCISION:  - INVASIVE DUCTAL CARCINOMA, SBR GRADE 3, MEASURING 2.4-CM - INTERMEDIATE NUCLEAR GRADE, DUCTAL CARCINOMA IN SITU, SOLID TYPE - INVASIVE TUMOR INVOLVES INFERIOR SURGICAL RESECTION MARGIN AND PRESENT WITHIN 1 MME FROM MEDIAL SURGICAL RESECTION MARGIN - BIOPSY SITE CHANGES WITH FIBROSIS - SEE SYNOPTIC REPORT. B. LYMPH NODES, RIGHT, AXILLARY DISSECTION: - METASTATIC CARCINOMA TO TWO OF SEVENTEEN LYMPH NODES (2/17), LARGEST MEASURING 2.5-CM,I WITH EXTRANODAL EXTENSION. C. SOFT TISSUE, ADDITIONAL WHITE AXILLARY, EXCISION: - FIBROADIPOSE TISSUE WITH FAT NECROSIS, NO TUMOR SEEN. SYNOPTIC REPORT - BREAST Specimen Type: Excision
+
+--- Page 2 ---
+Needle Localization: No Laterality: Right Invasive Tumor: Present Multifocality: No WHO CLASSIFICATION  Invasive ductal carcinoma, NOS 8500/3 Tumor size: 2.4cm Margins: Involved at inferior Extent:: focal Tubular Score: 3 Nuclear Grade: 2 Mitotic Score: 3  Modified Scarff Bloom Richardson Grade: Necrosis: Absent Vascular/Lymphatic Invasion: Present Extent: focal Lobular neoplasia:  None Lymph nodes: Axillary dissection. Lymph node status: Positive 2 / 17 Extranodal extension Micrometastases: No DCIS present Margins uninvolved by DCIS DCIS Quantity:Estimate 2% DCIS Type: Solid DCIS Location:Associated with invasive tumor Nuclear grade: intermediate Necrosis: Absent ER/PR/HER2 Results ER: Positive PR: Positive HER2: Pending by FISH Pathological staging (pTN): pT 2 N 1a  Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition. SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimen:  Surgical Excision Block Number: A4 ER: Positive Allred Score: 8 = Proportion Score 5 + Intensity Score 3 PR: Positive Allred Score: 4 = Proportion Score 2 + Intensity Score 2 COMMENT:  The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate. intensity of staining, 3 = strong intensity of staining), with a scoring range from O to 8.. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2. METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours..  Immunohistochemistry was performed using the mouse anti-human ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) provided by following the manufacturer s instructions. This assay was not modified.. Interpretation ot tne ER/PR immunohistochemical stain is guided by published results in the medical literature,.  information provided by the reagent manufacturer and by internal review of staining performance SYNOPTIC REPORT - BREAST HER-2 RESULTS Specimen: Surgical Excision Block Number: A4 Interpretation: EQUIVOCAL Intensity: 2+ % Tumor Staining: 10% Fish Ordered: Yes, on Date.
+
+--- Page 3 ---
+METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no Ionaer than 24 hours. Her2 analysis was performed using the FDA approved Dako HercepTest (TM) test kit : ) using rabbit anti- human HER2. This assay was not modified. External kit-slides provided by the manufacture. cell lines with high, low and negative HER2 protein expression) and in-house known HER2 amplified control tissue were evaluated along with the test tissue. Adequate, well preserved, clear-cut invasive carcinoma was identified for HER2 evaluation. Interpretation of the HER2 immunohistochemical stain is guided by published results in the medical literature.  information provided by the reagent manufacturer and by internal review of staining performance.. This assay has been validated according to the 2007 joint recommendations and guidelines from ASCO and CAP  and from the NCCN HER2 testing in Breast Cancer Task Force. The Pathology Department takes full responsibility for this test's performance. CLINICAL HISTORY: None provided. PRE-OPERATIVE DIAGNOSIS: Right breast cancer. INTRAOPERATIVE CONSULTATION DIAGNOSIS: A: Right breast, lumpectomy: Mass is 0.6 cm from the closest inferior margin. By Dr., called to Dr. at P.m. ADDENDUM:  Results of the gross examination performed on specimen A were omitted from the original report and are as follows: PathVysion HER-2 DNA Probe Kit Case No Analytical Interpretation of Results: HER-2 NOT AMPLIFIED Clinical Interpretation of results Amplification of the HER-2 gene was evaluated with interphase fluorescence in-situ hybridization (FISH) on formalin-fixed paraffin embedded tissue sections using a chromosome 17 centromeric probe and a HER-2 probe that spans the entire HER-2 gene in the by Dr. A majority of tumors cells displayed 2 chromosome 17 signals and 2 HER-2 signals, with a HER-2/CEP 17 Ratio </=2.0, consistent with no amplification of the HER2/neu gene. Block used A4 Source of case: Tissue fixation formalin-fixed tissueOutside Case No: NA Tissue source breast Results interpreted: yes HER2/CEP17 ratio: 0.9 This ratio is derived by dividing the total number of LSI HER-2/neu signals by the total number of CEP17 signals in at least 20 interphase nuclei with nonoverlapping nuclei in the neoplastic  mammary epithelial cells. Cells with no signals or with signals of only one color are disregarded. Method of ratio enumeration: manual count Limitations The Vysis PathVysion Kit is not intended for use to screen for or diagnose breast cancer. It is  intended to be used as an adjunct to other prognostic factors currently used to predict disease-free.  and overall survival in stage ll, node-positive breast cancer patients. In making decisions regarding.  adjuvant CAF treatment, all other available clinical information should also be taken into consideration, such as tumor size, number of involved lymph nodes, and steroid receptor status. No. treatment decision for stage II, node-positive breast cancer patients should be based on HER-2/neu gene amplification status alone. Overview of this test FDA APPROVED REAGENT  PathVysion HER-2 DNA Probe Kit is FDA approved for selection of  patients for whom Herceotin theranv is heina considered. These tests were performed in the under the direction of Dr. The results of these studies should always be interpreted in the context of the clinical, morphological, and immunophenotypic diagnosis.. Gross Dictation: Microscopic/Diagnostic Dictation: Pathologist, Final Review: Pathologist Final: Pathologist, ( Addendum Review: Pathologist. Addendum Final: Patholoniet Addendum: Pathologist, Addendum Final: Pathologist,
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diff --git a/output/text/a602084c-5425-4e2f-a30a-9f2b97e42942.txt b/output/text/a602084c-5425-4e2f-a30a-9f2b97e42942.txt
new file mode 100644
index 0000000000000000000000000000000000000000..19e6932f81eb2da2194fffe9d36d18e35614a01c
--- /dev/null
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+
+--- Page 1 ---
+UUID:A5AED5F0-A144-4615-AF78-539B8523D15F TCGA-A7-A3J0-01A-PR Redacted Final Surgical Pathology Report 1co-0-3 cccnomn,nVssNC Muti`niens 348ij3 Procedure: Sitt: breast, Nos c50.9 Diagnosis A. Sentinel lymph nodes, right axilla, biopsy: There is no evidence of malignancy in either of 2 lymph nodes. B. Breast, right, excisional biopsy: Invasive mucinous type carcinoma, Nottingham grade 1. Fibrocystic changes. Microscopic Description: A. There is no evidence of malignancy in either of 2 lymph nodes. [At the request of some staff oncologists and in keeping with the for keratin were not used on the sentinel iymph node sections in this case. These stains can be obtained if desired.  Our paraffin blocks are retained for 10 years. (Weaver DL et al. New Engl J Med 364:412, 2011. Schwartz GF et al. Cancer 94(10):2542, 2002)]. B. Invasive carcinoma: Histologic type: Invasive mucinous carcinoma Nottingham grade: Architectural score: 3 Nuclear score: Mitotic score: Mitotic index: 4 mitoses/ 10 HPFs (1 HPF = 1.96 sq. mm) Tumor size: 2.5 cm Specimen margins: Negative for malignancy. Carcinoma is focally 1.9 mm from the red (anterior) margin. Vessel invasion: Absent Calcification: Absent Non-tumorous breast: Fibrocystic changes are present including cyst formation, sclerosing adenosis, columnar metaplasia and intraductal epithelial hyperplasia without atypia, benign calcification and apocrine metaplasia. TNM stage: T2 NO Prognostic markers:  See previous biopsy. Specimen A. Right axillary sentinel node B. Right breast biopsy long stitch anterior short stitch superior Clinical Information Right breast cancer Gross Description Specimen A is received unfixed labeled right axillary sentinel nodes and consists of 2 pieces of yellow and red soft tissue measuring 3.5 x 2.5 x 1 and 2.8 x 2 by 1.3 cm. Sections after fixation. One LN in blocks 1-3, second LN in blocks 4-7
+
+--- Page 2 ---
+Specimen B. is received unfixed labeled right breast biopsy. The specimen is received in a Transpec container and consists of yellow and red piece of soft tissue measuring 8.5 by 7.5 by approximately 3 cm. The external surface of the specimen is inked as indicated below. Anterior: Red Posterior:  Orange Lateral: Blue Medial: Green Superior: Yellow Inferior: Black There is a relatively central mucinous appearing firm tumor measuring 2.2 x 2.5 by approximately 2.5 cm. A portion of the specimen is taken
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diff --git a/output/text/a61077e4-3082-4572-ac38-307d9e7b26e2.txt b/output/text/a61077e4-3082-4572-ac38-307d9e7b26e2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2506701141d87d0f90267cb96bfe13ea280ae9fb
--- /dev/null
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@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+UUID:66C80EC0-37D4-4F88-9988-2CA3D652C8C3 Redacted Sample # Gender: Female DOB: 10/12 Race: Black Report Date: Pathology Report 1cs-j-3 Surgical Pathology Report cnciona, Wro#hulial,Nos 81d0f3 FINAL PATHOLOGIC DIAGNOSIS PK Site: b1vdd nos Ct"7.9 A. Right pelvic lymph nodes; dissection: CqCF blnddw,wall, sntuior Cb7.3 - Fourteen lymph nodes, no tumor (0/14). ,lw 1/3/1x B. Left pelvic lymph nodes; dissection: - Twenty nine lymph nodes, no tumor (0/29) C. Right ureter, excision:. - Portion of ureter, no tumor. D. Bilateral ovaries, left fallopian tube and uterus; hysterectomy and salpingo-oophorectomy: - Uterus with benign secretory endometrium, adenomyosis, and multiple leiomyomas (largest 6 cm). - Bilateral ovaries with physiologic changes. - Left fallopian tube, no tumor.. E. Urinary bladder and round ligament; cystectomy: - Invasive high grade urothelial carcinoma with extensive squamous differentiation, see pathologic parameters. F. Right pelvic lymph nodes; dissection: - Fifteen lymph nodes, no tumor (0/15). Urothelial Carcinoma Pathologic Parameters 1. Tumor type: Invasive urothelial carcinoma with extensive squamous differentiation. 2. Grade of tumor: High grade. 3. Depth of invasion: Muscularis propria, outer half. 4. Tumor distribution: Solitary, anterior wall, 6.0 cm exophytic mass. 5. Ureteral margins: Negative for tumor. 6. Distal urethral margin: Negative for tumor. 7. Soft tissue margin or serosa: Negative for tumor. 8. Lymph nodes: Negative for tumor (0/58). 9. pTNM: pT2b,N0,MX. Effective . this Checklist utilizes the 7th edition TNM staging system for Bladder of the American Joint Committee on Cancer (AJCC) and the International Union Against Cancer (UICC)
+
+--- Page 2 ---
+xx [], mD Interpretation performed by the Attending Pathologist and reviewed with the Resident/Fellow, [], M.D., Ph.D.. Electronically Signed Out by [], MD Clinical History: The patient is a :year-old female with history of bladder cancer undergoing. cystectomy. Specimens Received: A: Right pelvic lymph nodes. B: Left pelvic lymph nodes C: Right distal ureter D: Ovaries, tubes and uterus E: Bladder and round ligament F: Right pelvic lymph node Gross Description: The specimens are received in six containers each labeled with the patient's name and medical record number.. A. The first container is additionally identified as, "right pelvic lymph nodes". Received fresh for intraoperative diagnosis is a 6.5 x 4.8 x 1.5 cm aggregate of lobulated yellow fibrofatty tissue. The specimen is dissected for lymph nodes to reveal multiple apparent lymph nodes ranging from 0.2-2.5 cm in greatest dimension. One representative lymph node is submitted for frozen section and read as "reactive lymph node, NEOT" by Dr. []. The frozen section remnant is submitted as A1 FS. The remaining apparent lymph nodes are submitted as follows: A2-4: 2 lymph nodes each cassette; A5-6: 4 lymph nodes each cassette B. The second container is additionally identified as, "left pelvic lymph node". Received fresh for intraoperative diagnosis is a 6.5 x 4.5 x 1.0 cm aggregate of lobulated yellow fibroadipose tissue. The specimen is dissected for lymph nodes to reveal multiple appearing lymph nodes ranging from 0.8-3.0 cm in greatest dimension. Representative sections of a small lymph node and a large node are submitted for frozen section and read as "2 active lymph nodes, NEOT' by Dr. [] The frozen section remnant is submitted as B1 FS and B2 FS. The remaining appearing lymph nodes are submitted as follows: B3: Remaining portion of large lymph node; B4: Remaining portion of the small lymph node; B5-7: 5 lymph nodes each cassette; B8: 7 lymph nodes; B9: One lymph node bisected; B10: One lymph node sectioned; B11-12: One lymph node sectioned C. The third container is additionally identified as, "right distal ureter". Received fresh and placed in formalin is a 0.5 cm unoriented segment of ureter. The specimen is sectioned and entirely submitted as C1.. D. The fourth container is additionally identified as, "uterus, tubes,. ovaries". Received fresh and placed in formalin is a hysterectomy specimen, weighs 479.1 gm with bilateral adnexa. The uterus measures 7.8 cm from fundus to
+
+--- Page 3 ---
+lower uterine segment by 7.5 cm from cornu to cornu by 11.3 cm from anterior to posterior. The serosal surface is red-tan, and glistening with a prominent serosal bulge (2.4 cm in greatest dimension, at anterior/fundal aspect). The cervix is not present with the specimen. The anterior surface is inked blue and the posterior surface is inked black. The specimen is opened revealing a 0.9 cm endocervical canal remnant lined with tan-pink rugated mucosa and an endometrial cavity distorted by submucosal nodules measuring 0.5 cm from cornu to cornu by 6.5 cm in length and lined with hemorrhagic and thickened, endometrium measuring 0.2 cm in thickness. The specimen is sectioned revealing pink-tan myometrium which is distorted on the anterior, posterior and fundus with multiple, rubbery and whorled nodules measuring from 0.7-6.0 cm. On cut section the nodules are devoid of hemorrhage, calcifications, necrosis, or hemorrhage. The myometrium has a maximum wall thickness of 3.5 cm and is coarsely trabeculated. The right adnexa consist of a 4.5 cm long and 3.0 cm wide portion of soft tissue. The fallopian tube with fimbriated end is not identified. The serosa is pink-red and glistening. The attached white-tan, cribriform ovary measures 4.5 x 2.5 x 1.6 cm and is sectioned to revealed white dense ovarian stroma with a 2.5 cm hemorrhagic cyst filled with semisolid material. The left adnexa consist of a 3.5 cm long and 2.5 cm diameter fimbriated fallopian tube. The serosa is pink-red and glistening. The specimen is serially sectioned revealing a pinpoint lumen and a 0.4 cm wall thickness. The attached white-tan, cribriform ovary. measures 3.8 x 2.1 x 1.3 cm and is sectioned to revealed fibrotic white and ovarian stroma with few small cysts measuring up to 2.5 cm in greatest dimension and filled with hemorrhagic solid material.. Representative sections are. submitted as follows: D1: Anterior cervix remnant, entirely submitted D2: Posterior cervix remnant, entirely submitted D3-4: Anterior endomyometrium (D3: With nodules, D4: Full thickness) D5-6: Posterior endomyometrium D7: Whorled nodules D8: Right ovary and right adnexal soft tissue. D9: Left fallopian tube D10: Left ovary and surrounding soft tissue. E. The fifth container is additionally identified as, "bladder and round ligament". Received fresh and placed in formalin is a 61.9 g, 17 x 13.5 x 3.7 cm cystectomy specimen with attached mesenteric fat. The bladder measures 9 x 7 x 3 cm. The right ureteral stump measures 2.2 x 0.6 cm and the left 1.0 x 0.7 cm, and both demonstrate patent lumina. The urethral margin is inked black. The right half of the bladder is inked blue and the left half is inked black. Also received in the same container are 2 detached tubular structures, measuring 2.8 x 1.0 cm and 4.3 x 0.6 cm. The bladder is opened laterally along the urethra. The bladder demonstrates a 6.0 x 5.8 x 2.0 cm exophytic, pink-tan, friable mass attached to the anterior wall and 2.3 cm from the urethral margin. Serial sectioning reveals tumor invasion into the submucosa to a depth of 0.5 cm, extending to 1.5 cm of the inked margin. There is a 2.0 x 1.5 cm ill-defined area of plaque-like raised mucosa identified in the posterior wall, about 2 cm lateral to the. aforementioned tumor. The remainder of the mucosa is tan-brown, edematous, and glistening with a uniform 1.2 cm wall thickness. The bilateral ureteral orifices are identitied and probe patent. Gross photographs are taken. Representative sections are
+
+--- Page 4 ---
+submitted as follows:. E1: Left ureteral margin E2: Right ureteral margin E3: Distal urethral margin. E4-5: Mass at deepest invasion (full thickness, tandem sections) E6-10: Multiple tumor sections, and surrounding normal looking mucosa E11: Raised lesion on the posterior wall E12: Uninvolved dome E13: Uninvolved posterior wall E14: Uninvolved right wall. E15: Uninvolved left wall. E16: Uninvolved trigone F. The sixth container is additionally identified as, "right pelvic lymph node". Received fresh and placed in formalin is a 7.0 x 2.5 x 2.5 cm aggregate of lobulated yellow fibrofatty tissue. The specimen is dissected for lymph. nodes to reveal multiple apparent lymph nodes ranging from 1.0-5.0 cm in. greatest dimension. All apparent lymph nodes are submitted as follows: F1-3: 5 lymph nodes each cassette, F4: One lymph node bisected; F5-6: One lymph node sectioned xx [], M.D., Ph.D. Intraoperative Consult Diagnosis: A1 FS: Reactive lymph node, NEOT B1 and B2 FS: 2 reactive lymph nodes, NEOT
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diff --git a/output/text/a62704c5-e357-4235-8f48-9acbc2782a3f.txt b/output/text/a62704c5-e357-4235-8f48-9acbc2782a3f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..60316ceea52fea4431824e680653b9b0f27ec68d
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+1cd -0: 3 8100|3 urothlirl.Nos Cicni-omo 1>/30/10 : b|add, N0s C l7.9 S'ite C: SURGICAL PATHOLOGY REPORT Patient Name: Accession #: Date of Procedure: Med. Rec. #: Location: Date of Receipt: DOB: (Age: 57) Urology Gender: M Service: Date of Report: Ref. Physician: Account #: Patient Address: Billing Type: INPATIENT Additional Copy to: Ref. Source: Clinical Diagnosis & History: 58 year old male with large volume HG bladder carcinoma. Specimens Submitted: 1: SP: Rectus sheet, biopsy t 2: SP: Urethra, margin; biopsy ., 3: SP: Bladder and prostate; radical cystoprostatectomy 4: SP: Lymph nodes, right pelvic; dissection 5: SP: Lymph nodes, left pelvic; dissection 6: SP: Pre-vesicle tissue, biopsy 7: SP: Abdominal wall hernia sac; resection 8: SP: Small bowel; resection 9: SP: Ureter, left distal; biopsy 10: SP: Ureter, right distal; biopsy 11: SP: Ureter, right distal high proximal margin; biopsy 12: SP: Ureter, right distal high proximal margin #2; biopsy DIAGNOSIS: 1. SP: Rectus sheet, biopsy Benign fibroadipose tissue. 2. SP: Urethra, margin; biopsy' Benign prostatic urethra. 3. SP: Bladder and prostate; radical cystoprostatectomy: a. UUID: 33855148-B5B5-46AE-892D-61864D7711840 TCGA-DK-A1AA-01A-PR Redacted Tumor Type: Invasive urothelial carcinoma, NOS. Histologic Grade: High grade Pattern of growth of the Non-Invasive component:  Papillary Pattern of growth of the Invasive component: Inverted / Nodular Tumor Multicentricity: Identified Bladder Local Invasion: Perivesical soft tissues There is a perforation through the bladder wall with focal nests of carcinoma infiltrating through the perivesical soft tissue Page 1 of 7
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT Extravesical Tumor Extension: Ureters uninvolved Urethra uninvolved Vascular Invasion: Not identified Perineural Invasion: Not identified Surgical Margins: Free of tumor Non-Neoplastic Mucosa: Exhibiting proliferative cystitis (Brunn's nests, cystitis cystica, cystitis glandularis) There is a perforation through the bladder wall with exuberant inflammation, foreign body giant cell reaction and  myofibroblastic proliferation Prostate: Other see part b Seminal Vesicles: Not identified Perivesical Lymph Nodes: Not identified The Pathologic Stage is (AJCC 2002): pT3 (Invasion of perivesicle soft tissue) PR0 (No involvement of prostate) b Tumor Type: Adenocarcinoma) Gleason's Grade: Primary Gleason grade:3 Secondary Gleason grade:4 Total Gleason score:7 Tumor Location: Involves Right posterior Involves Right anterior Involves Left posterior Involves Left anterior Dominant tumor mass located in: right and left posterior apex-mid Vascular Invasion: Not Identified Perineural Invasion: Identified Tumor Multicentricity: Multicentric foci of invasive carcinoma are present High Grade Prostatic Intraepithelial Neoplasia: Identified Capsule: Tumor invades into, but not beyond prostate capsule Seminal Vesicles: Not involved Page 2 of 7
+
+--- Page 3 ---
+SURGICAL PATHOLOGY REPORT Bladder Neck: Not Involved Surgical Margins: Free of tumor Non-Neoplastic Prostate Exhibits nodular hyperplasia Staging (AJCC 1997): pT2b (confined to the prostate & capsule, involving both lobes) 4. SP: Lymph nodes, right pelvic; dissection: Five benign lymph nodes (0/5). 5. SP: Lymph nodes, left pelvic; dissection: Eight benign lymph nodes (0/8). 6. SP: Pre-vesical tissue, biopsy: Necrotic tissue and fibrinopurulent exudate.. 7. SP: Abdominal wall hernia sac; resection:. Hernia sac. 8. SP: Small bowel; resection: Unremarkable segment of small bowel. 9. SP: Ureter, left distal; biopsy: Benign segment of ureter. 10. SP: Ureter, right distal; biopsy: Benign segment of ureter. 11. SP: Ureter, right distal high proximal margin; biopsy: Benign segment of ureter. 12. SP: Ureter, right distal high proximal margin #2; biopsy: Benign segment of ureter.. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE Reviewed and approved this report. Special Studies: Result Speci al Stain Comment RECUT AE1:AE3 IMM RECUT NEG CONT  Page 3 of 7
+
+--- Page 4 ---
+SURGICAL PATHOLOGY REPORT Gross Description: 1) The specimen is received fresh for frozen section labeled, "rectus sheet", and consists of one tan red soft tissue measuring 0.9 x 0.7 x 0.2 cm. Entirely submitted. Summary of sections: FSC-frozen control 2) The specimen is received fresh for frozen section labeled, "urethral margin", and consists of one tan pink soft tissue measuring 1.5 x 0.7 x 0.3 cm. Entirely submitted.. Summary of sections: FSC-frozen contro! 3) The specimen is received fresh labeled, "Bladder, prostate, seminal vesicles, urethra, urachus, perivesical tissue and nodes, left rectus muscle". It consists of a cystoprostatectomy specimen with attached soft tissue at the superior aspect measuring 18.5 cm  from superior to inferior, 14.5 cm laterally and 6 cm from anterior to posterior. A disrupted cyst-like structure, probably representing an organized hematoma is identified in the soft tissue, partially covered by skeletal muscle on the anterior surface. The inner  surface of the structure is hemorrhagic. The skeletal muscle portion measures 6 x 2.2 x 0.3 cm. The anterior aspect of the bladder is inked black and the posterior blue; the soft tissue margin is inked green. The prostatic urethral margin is shaved and submitted. A urachal remnant measuring approximately 6 cm in length and 0.3 cm in diameter is identified. The bladder is opened along the anterior midline to reveal seven cauliflower-like fungating masses occupying most of the bladder cavity measuring from 0.5 x 0.5 x 0.5 cm to 5 x 6 x 4 cm, situated on the anterior, right and left lateral and posterior walls and dome. The stalk of the left laterai tumor is 1.6 cm from the left orifice and the stalk of the right lateral tumor is adjacent to the orifice. Both ureters are probe patent  measuring up to 0.2 cm in maximum diameter. Serial sectioning reveals that the tumors are limited to the stalk and do not show gross invasion. Serial sectioning through the anterior portion /dome of the bladder reveals a perforation with a sinus tract draining into the soft tissue attached to the bladder, 0.2 cm from the hematoma. The remaining bladder mucosa adjacent to the tumors shows ulcerations. Discrete perivesical lymph nodes are not grossly identified and the specimen is submitted for lymph node dissection. The prostate is serially sectioned to reveal unremarkable prostate parenchyma. The prostate is submitted entirely. TPS is submitted, photographs are taken. Summary of sections: UTHM - urethral margin RUM - right ureter margin LUM - left ureter margin URM - urachal margin T1 - tumor 1 (5 x 3 x 2 cm, left lateral/anterior wall) T2 - tumor 2 (3.5 x 3 x 2 cm, ieft lateral wall) T3 - tumor 3 (0.5 x 0.5 x 0.5, posterior wall) T4,T5 - tumors 4 and 5 (1.2 x 0.7 x 0.6; 0.6 x 0.4 x 0.3 cm; posterior wall) T6 - tumor 6 (0.7 x 0.6 x 0.6 cm, right lateral wall) T7 - tumor 7 (5 x 6 x 4 cm, right lateral wall) T8 - tumor 8 (3 x 2 x 0.5 cm, right lateral wall) T9 - tumor 9 (1.3 x 1.5 x 0.5 cm, right lateral wall) P - perforation TRI - trigone  RUO - right ureter orifice LUO - left ureter orifice  RSV - right seminal vesicle LSV - left seminal vesicle RAP - right apex prostate LAP - left apex prostate RAM - right anterior mid prostate RPM - right posterior mid prostate LAM - left anterior mid prostate LPM - left posterior mid prostate RAB - right anterior base prostate RPB - right posterior base prostate LAB - Jeft anterior base prostate LPB - left posterior base prostate ADD -- additional sections of prostate Page 4 of 7
+
+--- Page 5 ---
+SURGICAL PATHOLOGY REPORT 4) The specimen is received in formalin, labeled "right pelvic lymph nodes" and consists of multiple pieces of fatty tissue measuring. in aggregate 7 x 5 x 1.5 cm. The specimen is submitted for lymph node dissection. Lymph nodes range in size from 0.5 to 2.0 cm. in greatest dimension. All identified lymph nodes are submitted.. Summary of sections: LN-lymph nodes BLN-bisected lymph nodes LICH 5) The specimen is received in formalin, labeled "left pelvic lymph nodes" and consists of multiple pieces of fatty tissue measuring in aggregate 5 x 4 x 1.5 cm. The specimen is submitted for lymph node dissection. Lymph nodes range in size from 0.4 to 2.0 cm in greatest dimension. All identified lymph nodes are submitted.. Summary of sections: LN-lymph nodes BLN-bisected lymph nodes 6) The specimen is received in formalin, labeled "Necrotic pre-vesical tissue" and consists of multiple fragments of tan necrotic soft  tissue measuring 3.5 x 2 x 0.6 cm in aggregate. Representative section is submitted. Summary of sections: U-undesignated 7) The specimen is received in formalin, labeled "Abdominal wall hernia sac" and consists of a piece of ovoid-shaped tan fibromembranous sac measuring 3.0 x 2.5 x 2.5 cm. Cut section reveals a sac filled with yellow adipose tissue. Representative sections are submitted. Summary of sections: U-undesignated 8) The specimen is received in formalin, labeled "Small bowel" and consists of a piece of unoriented bowel measuring a 3.0 cm in. length and 2.0 cm in diameter. Both ends of the bowel are stapled. Cut section reveals a mucosal wall thickening up to 0.7 cm. The staples are removed and representative sections submitted. Summary of sections: BE - both ends  RS - representative sectionse 9) The specimen is received in formalin, iabeled "Distal left ureter" and consists of unoriented tan tubular fibroelastic soft tissue measuring 0.8 cm in length and 0.5 cm in diameter. Entirely submitted in toto.. Summary of sections: U-undesignated 10) The specimen is received in formalin, labeled "Distal right ureter, large clip on proximal margin" and consists of an oriented tan.  tubular fbroelastic tissue measuring 2.5 cm in length and 0.6 cm in diameter. A clip is attached to one end. The specimen is serially sectioned and entirely submitted.. Summary of sections: CE - clip end OE - open end SS - serial section, clip end to open end, remaining specimen Page 5 of 7
+
+--- Page 6 ---
+SURGICAL PATHOLOGY REPORT 11) The specimen is received in formalin, labeled "Distal right ureter, high proximal margin" and consists of a piece of unoriented  tan tubular fibroelastic tissue measuring 0.6 cm in length and 0.3 cm in diameter. Entirely submitted in toto. Summary of sections:. U-undesignated 12) The specimen is received in formalin, labeled "Distal right ureter, high proximal margin #2" and consists of a piece of  unoriented tan tubular fibroelastic tissue measuring 0.5 cm in iength and 0.4 cm in diameter. Entirely submitted in toto. Summary of sections:. U-undesignated Summary of Sections:e Part 1: SP: Rectus sheet, biopsy . Block Sect. Site PCs 1 fsc Part 2: SP: Urethra, margin; biopsy Block Sect. Site PCs 1 fsc Part 3: SP: Bladder and prostate; radical cystoprostatectomy Block Sect. Site PCs 4 ADD 4 1 LAB 1 LAM 1 1 1 LAP 1 1 LN 1 1 LPB 1 1 LPM 1 1 LSV 1 LUm 1 1 1 LUO 1 11 P 11 2 q 2 1 RAB 1 1 RAM 1 1 RAP 1 1 RPB 1 1 RPM 1 1 RSV 1 1 RUM 1 1 RUO 1 3 T1 3 T3 1 1 T4,5 1 1 T6 1 4 T7 4 1 T8 1 1 T9 1 1 TRI 1 1 URM 1 1 UTHM 1 Part 4: SP: Lymph nodes, right pelvic; dissection Block Sect. Site PCs Page 6 of 7
+
+--- Page 7 ---
+SURGICAL PATHOLOGY REPORT BLN 6 3 3 LN 1 Part 5: SP: Lymph nodes, left pelvic; dissection Sect. Site PCs Block 2 BLN 1 6 LN 3 Part 6: SP: Pre-vesicle tissue, biopsy pCs Sect. Site Block 1 U 1 Part 7: SP: Abdominal wall hernia sac; resection PCs Block Sect. Site 2 U 2 Part 8: SP: Small bowel; resection Sect. Site PCs Block BE 1 1 RS 2 2 Part 9: SP: Ureter, left distal; biopsy Sect. Site PCs Block U 1 1 Part 10: SP: Ureter, right distal; blopsy Sect. Site PCs Block CE 1 1 1 OE 1 ss 6 2 Part 11: SP: Ureter, right distal high proximal margin; biopsy Sect. Site PCs Block U 1 1 Part 12: SP: Ureter, right distal high proximal margin #2; biopsy PCs Sect. Site Block U 1 1 Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. : Benign fibroadipose tissue FROZEN SECTION DIAGNOSIS: SP: Rectus sheet 1.  PERMANENT DIAGNOSIS: SAME 2. FROZEN SECTION DIAGNOSIS: SP: Urethral margin (): Benign PERMANENT DIAGNOSIS: SAME END OF REPORT  Page 7 of 7
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diff --git a/output/text/a6304212-50b6-4b81-827b-35f536102c8e.txt b/output/text/a6304212-50b6-4b81-827b-35f536102c8e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a9843d57de6e0fda773753e466a598f297316efc
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+
+--- Page 1 ---
+UUID:D4B5B70A-ED8A-4016-98DD-88E15A9B808D TCGA-UZ-A9PX-01A-PR Redacted SURGICAL PATHOLOGY REPORT Patlent Name Accession #: Med. Rec.#:  Visit #: Service Date: DOB: Sex: Male Received: Soc. Sec. # Location: Client: Physician(s): FInal Pathologic Diagnosis Right kidney, radical nephrectomy: Multifocal papillary renal cell carcinoma, Fuhrman. grade 3, 4.2 cm largest tumor size, negative margins. Comment: Kidney Tumor Synoptic Comment - Histologic type: Renal cell carcinoma, papillary type. - Grade: Fuhrman grade 3. - Tumor size: Three distinct separate tumor masses are present, the largest is 4.2 cm. - Sites within kidney: Upper pole, lower pole, mid kidney. IcD 0 3 - Renal pelvis: Normal.. - Ureter: Normal. 8q60|3 - Renal sinus: Normal.d. Site, EBeeney No5Co4.9 - Hilar renal veins: Normal. - Intrarenal veins and lymphatics: Normal. - Adrenal gland: Not present. bJ3|3D|j4f - Capsule/perirenal fat: Tumor does not penetrate capsule. - Lymph node status: Negative, total number of nodes examined : 2.. - Resection margins: - Ureter: Negative (tumor is greater than 1 cm from margin).. - Renal vein: Negative (tumor is greater than 1 cm from margin).. - Soft tissue: Negative (tumor is 0.1 cm from margin). - AJCc Stage: pT1NOMX. Specimen(s) Received A:Right kidney (fresh) Clinical History Page 1 of 2
+
+--- Page 2 ---
+The patient is a. -year-old male wno, per the electronic medical recorr. has three renal masses of the right kidney e now undergoes a laparoscopic right nephrectomy. Gross Description The specimen is received fresh in one part, Iabeled with the patient's name, medical record number and "right kidney," and consists of a single kidney (17.5 x 7.8 x 6.3 cm, 448.5 gm) with attached ureter (4.5 x 0.4 x 0.2 cm). The specimen contains three nodules. Nodule 1 is located in the Inferior pole and is composed of a well-circumscribed, yellow-brown, soft, spheroid nodule (4.2 x 3.9 x 3.8 cm) and comes to within 0.6 cm of the renal sinus, 4.5 cm of the vascular margin, 3.2 cm of the ureteral margin, and comes to within 0.1 cm of the soft tissue margin. The soft tissue overlying this nodule is loose and non-adherent. Nodule 2 is located on the superior pole of the kidney and is composed of a yellow-tan, rubbery, well-circumscribed, spheroid nodule (1.6 x 1.6 x 1.2 cm). It is 1.6 cm from the renal sinus,. 5.5 cm from the vascular margin, 8.5 cm from the ureteral margin, and 0.2 cm from the soft tissue margin. The overlying soft tissue is loose and non-adherent. Nodule 3 is located at the mid kidney and is composed of a yellow-gold, soft, well-circumscribed, ovoid mass (3.1 x 1.6 x 2.5 cm). It is 0.1 cm from the soft tissue margin, 0.4 cm from the renal sinus, 3.5 cm from the vascular margin, and 9.1 cm from the ureteral margin. The overlying soft tissue is loose and non-adherent. The renal arterial wall is thickened and yellow. The renal sinus is extensively dissected for lymph nodes. The renal vein is free of tumor. There is no adrenal gland present after extensive dissection. Representative sections are submitted for microscopic evaluation as follows:. Cassette A1: Ureteral margin and cross-section. Cassette A2: Vascular margins. Cassette A3: Nodule 1, in relation to soft tissue margin, renal pelvis.. Cassette A4: Nodule 1, in relation to capsule. Cassette A5: Nodule 1, in relation to renal sinus, pelvis.. Cassette A6: Nodule 1, in relation to renal capsule.. Cassette A7: Nodule 2, in relation to soft tissue margin, renal capsule.. Cassette A8: Nodule 2, in relation to soft tissue margin.. Cassette A9: Nodule 3, in relation to soft tissue margin, renal capsule.. Cassette A10: Nodule 3, in relation to soft tissue margin, renal capsule.. Cassette A11: Nodule 3, in relation to renal pelvis, soft tissue margin. Cassette A12: One candidate lymph node, bisected.. Cassette A13: Multiple candidate lymph nodes, submitted intact.. Cassette A14: Unremarkable cortex, medulla and sinus, superior pole. Diagnosis based on gross and microscopic examinations. Final diagnosis made by attending pathologist following review of all pathology slides.. Pathology Resident Pathologist Electronicaily signed out on lw:16114 QUAUFIERS ewed|2 a413 Page 2 of 2
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diff --git a/output/text/a665591d-3fb3-4a8d-b6e9-70bb4000d431.txt b/output/text/a665591d-3fb3-4a8d-b6e9-70bb4000d431.txt
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index 0000000000000000000000000000000000000000..ce7703122423d20915f679161f89d7ca567e5588
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+
+--- Page 1 ---
+This is an invasive, moderately differentiated adenocarcinoma of the colon (G2) with infiltration of the muscularis (pT2) without vascular infiltration (L0, V0). Tumor classification: ICDO-DA-M 8140/3 G2 pT2, L0, V0 pN0 (0 of 14) locally R0 M classification in the context of an oncology conference
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diff --git a/output/text/a673578a-9523-4483-bc27-1062999256ef.txt b/output/text/a673578a-9523-4483-bc27-1062999256ef.txt
new file mode 100644
index 0000000000000000000000000000000000000000..21acab3a035df191a9dd76c69443362270367aae
--- /dev/null
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+
+--- Page 1 ---
+Specimen(s) Received 1. Nck: left neck contents - Level I 2. Neck: Left neck contents - Level II 3. Neck: Left neck contents - Level IV 4. Neck: Left neck contents - Level III 5. Oral Cavity: Hemiglossectomy 6. Soft Tissue: Left posterior margin 7. Soft Tissue: Left lateral margin 8. Soft Tissue: Medial margin 9. Oral Cavity: Revision glossectomy 10. Surgical Waste Diagnosis 1. Left neck; level I: - Six lymph nodes, negative for malignancy (0/6) - Submandibular gland with no pathologic changes. 2. Left neck; level II: - Metastatic squamous cell carcinoma involving two of thirteen lymph nodes (2/13) a. Largest involved lymph node measures 1.6 cm. b. Extracapsular extension is present.. 3. Left neck; level IV: - Eight lymph nodes, negative for malignancy (0/8). 4. Left neck; level III: - Metastatic squamous cell carcinoma involving one of two lymph nodes (1/2) a.  Involved node measures 1.7 cm. b. Extracapsular extension is present. 5. Left hemiglossectomy:  Squamous cell carcinoma, poorly differentiated.. a.  Maximum tumour dimension 3.3 cm. b.  Maximum tumour thickness 1.0 cm.
+
+--- Page 2 ---
+C. Perineural invasion is present.. d.  Tumour is close (0.3 cm) to inferior floor of mouth and deep margins. e. All other margins are negative for malignancy (> 0.5 cm). 6. Left posterior margin: - Negative for malignancy. 7. Left lateral margin:. - Negative for malignancy. 8. Medial margin: - Negative for malignancy. 9. Revision glossectomy: - Skeletal muscle, negative for malignancy. 10. Surgical waste:. - Skin and fibroadipose tissue with no pathologic abnormality (gross examination only). Synoptic Data Specimen Type: Resection:Left hemiglossectomy.. Tumor Site: Tongue Histologic Type:. Squamous cell carcinoma, conventional Tumor Size: Greatest dimension: 3.3 cm. Tumor thickness: 1.0 cm Histologic Grade: G3: Poorly differentiated Venous/Lymphatic (Large/Small Vessel) Invasion (V/L): Absent Perineural Invasion: Present Margins: Margins uninvolved by tumor Margins uninvolved by tumor - Distance of tumor from closest margin: 0.3 cm Margins: Inferior floor of mouth and deep margins. Pathologic Staging (pTNM): pT2: Tumor of lip or oral cavity more than 2 cm but not more than 4 cm in greatest dimension pN2b: Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension for all aerodigestive sites except nasopharynx Number of regional lymph nodes examined: 29 Number of regional lymph nodes involved: 3 Extra-capsular extension of nodal tumor: Present pMX: Distant metastasis cannot be assessed Electronically Gross Description
+
+--- Page 3 ---
+1. The specimen is labeled with the patient's name and "left neck contents level I". It consists of. portion of fibroadipose tissue measuring 6.3 x 3.6 x 3.2 cm. a grossly unremarkable. submandibular gland is identified measuring 4.4 x 3.5 x 2.8 cm. Multiple lymph nodes ranging from 0.6 x 0.5 x 0.4 to 1.4 x 0.8 x 0.6 cm are identified. Representative sections are submitted. 1A submandibular gland 1B one lymph node bisected 1C multiple lymph nodes 1D two lymph nodes 2. The specimen is labeled with the patient's name and "left neck contents level II". It consists of portion of fibroadipose tissue measuring 4.3 x 2.2 x 1.6 cm. Multiple lymph nodes ranging from 0.4 x 0.4 x 0.3 to 1.6 x 0.7 x 0.7 cm are identified. Representative sections are submitted. 2A one lymph node bisected 2B multiple lymph nodes 2C multiple lymph nodes 2D one lymph node bisected 2E one lymph node bisected 3. The specimen is labeled with the patient's name and "left neck contents level IV". It consists of portion of fibroadipose tissue measuring 3.2 x 1.5 x 1 .3 cm. Multiple lymph nodes ranging from 0.2 x 0.2 x 0.2 to 1.6 x 0.5 x 0.4 cm are identified. Representative sections are submitted. 3A one lymph node bisected 3B multiple lymph nodes 3C multiple lymph nodes 4. The specimen is labeled with the patient's name and "left neck contents level Ill". It consists of portion of fibroadipose tissue measuring 6.4 x 2.5 x 1.3 cm. two lymph nodes measuring 0.9 x 0.6 x 0.5 and 1.7 x 0.6 x 0.5 cm are identified. Representative sections are submitted.. 4A one lymph node bisected 4D one lymph node bisected 5. The specimen is labeled the patient's name and as "left hemiglossectomy". It consists of a portion of left tongue measuring 3.4 SI x 2.5 ML x 7.0 cm AP cm. The specimen is oriented by the surgeon. There is an ill defined ulcerated brown-tan tumor involving the lateral surface of the tongue. The tumor measures 2.5 SI x 1.0 ML x 3.3 AP cm. It is located at 0.3 cm from the deep soft tissue margin, 1.3 cm away cm from the medial/superior tongue margin, 1.7 cm from the anterior tongue margin, 1.7 from the posterior tongue margin and is 0.8 cm away from the inferior floor of mouth margin. The remaining tongue mucosa is grossly unremarkable. The deep/medial soft tissue margin is painted with India ink and the posterior margin is painted with green dye. A representative section of the tumor including deep soft tissue margin is examined at intraoperative consultation. Representative sections are submitted 5A frozen section resubmitted 5B. anterior tongue margin 5C posterior tongue margin 5D inferior floor of mouth margin 5E tumor including superior tongue margin 5F tumor including inferior floor of mouth margin 5G. representative section tumor three pieces of tumor and two pieces of normal patients taken for tissue banking
+
+--- Page 4 ---
+6. The specimen is labeled with the patient's name and as "left posterior margin". It consists. of a fragment of tissue measuring 1.4 x 0.3 x 0.2 cm. The specimen is submitted in toto for frozen section. 6A  frozen section control. 7 The specimen is labeled with the patient's name and as "left lateral margin". It consists of a fragment of tissue measuring 1.5 x 0.4 x 0.2 cm. The specimen is submitted in toto for frozen section. 7A frozen section control. 8. The specimen is labeled with the patient's name and as "medial margin". It consists of a fragment of tissue measuring 2.5 x 0.4 x 0.5 cm. The specimen is submitted in toto for frozen section. 8A frozen section control. 9. The specimen is labeled the patient's name and as "revision glossectomy" It consists of a. portion of unoriented grossly unremarkable tongue measuring 1.5 x 0.5 x 0.4 cm. The margins. are painted with ink. 9A specimen serially sectioned and submitted in toto 10. The specimen container is labeled with the patient's name and as "surgical waste". Multiple. pieces of unoriented tan skin with underlying fibroadipose tissue received in 10% buffered. formalin. The tissue ranges in size from 1.5 x 0.5 x 0.6 cm to 5.5 x 3.8 x 0.3 cm. No gross abnormalities are noted. No tissue submitted for histologic examination. Quick Section Diagnosis 5A: Left hemiglossectomy deep margin: Deep margin is close (0.3 cm) to tumour but negative.. Spoke to surgeon in person at 6A-8A: Margins (left posterior, left lateral, medial): Negative for malignancy. Called at
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diff --git a/output/text/a6acb957-8630-46cb-a862-f3cfc90e786e.txt b/output/text/a6acb957-8630-46cb-a862-f3cfc90e786e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f8f5bdb40e44e7580e941a83bb553bd1a9c4aa1e
--- /dev/null
+++ b/output/text/a6acb957-8630-46cb-a862-f3cfc90e786e.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UUID:D8FA25D2-8119-47BA-8ECD-A2EA6E56E783 Page 1 of 5 TCGA-XF-A9SL-01A-PR Redacted Ordere CLINICAL DIAGNOSIS: High-grade poorly differentiated bladder cancer. FINAL DIAGNOSIS: RIGHT DISTAL URETER (A): FROZEN SECTION DIAGNOSIS: NO TUMOR IDENTIFIED FINAL DIAGNOSIS:  NO HIGH-GRADE UROTHELIAL ATYPIA OR MALIGNANCY IDENTIFIED LEFT DISTAL URETER (B) : FROZEN SECTION DIAGNOSIS: NO TUMOR IDENTIFIED FINAL DIAGNOSIS:  NO HIGH-GRADE UROTHELIAL ATYPIA OR MALIGNANCY IDENTIFIED ICD0 3 APICAL URETHRAL MARGIN (C) : FROZEN SECTION DIAGNOSIS:  NO TUMOR IDENTIFIED Carenonstrunslisnsl cell NDS s1zol3 FINAL DIAGNOSIS: BENIGN PROSTATIC PARENCHYMA NO MALIGNANCY IDENTIFIED pc#Dom y bader Cic 7 1 URINARY BLADDER AND PROSTATE AND PERIVESICAL NODES (D): QJ8|24li4 INVASIVE TRANSITIONAL CELL CARCINOMA (4.1 x 1.2 x 1.5 CM), GRADE III/IV, EXTENDING TO THE BLADDER DOME WALL TO INVOLVE PERIVESICAL SOFT TISSUE AND PERITONEUM EXTENSIVE LYMPHOVASCULAR SPACE AND PERINEURAL INVASION IDENTIFIED NO IN SITU CARCINOMA (FLAT LESION) IDENTIFIED MULTIPLE SATELLITE TUMOR NODULES ARE IDENTIFIED IN THE PERIVESICAL SOFT TISSUE RADIAL SURGICAL MARGINS ARE FREE OF TUMOR NO METASTATIC CARCINOMA IDENTIFIED IN THREE PERIVESICAL LYMPH NODES (O/3) PROSTATE: FOCAL PROSTATIC INTRAEPITHELIAL NEOPLASM (PIN II AND III) IDENTIFIED NO PROSTATIC ADENOCARCINOMA IDENTIFIED ADDITIONAL LEFT DISTAL URETER (E) :  NO HIGH-GRADE UROTHELIAL ATYPIA OR MALIGNANCY IDENTIFIED RIGHT PERIAORTIC LYMPH NODES (F) : NO METASTATIC CARCINOMA IDENTIFIED IN THREE LYMPH NODES EXAMINED (O/3) RIGHT COMMON ILIAC LYMPH NODES (G): NO METASTATIC CARCINOMA IDENTIFIED IN THREE LYMPH NODES EXAMINED (O/3) RIGHT EXTERNAL ILIAC LYMPH NODES (H) :  NO METASTATIC CARCINOMA IDENTIFIED IN SEVEN LYMPH NODES EXAMINED (O/7) RIGHT OBTURATOR LYMPH NODES (I) :  METASTATIC CARCINOMA IDENTIFIED IN ONE OF ELEVEN LYMPH NODES EXAMINED (1/11) RIGHT LYMPH NODE OF CLOQUET (J): NO METASTATIC CARCINOMA IDENTIFIED IN TWO LYMPH NODES EXAMINED (O/2) LEFT PERIAORTIC LYMPH NODES (K) :) FIBROADIPOSE TISSUE
+
+--- Page 2 ---
+Page 2 of 5 NO LYMPH NODES IDENTIFIEL LEFT COMMON ILIAC LYMPH NODES (L) :)  METASTATIC CARCINOMA IDENTIFIED IN TWO OF SEVEN LYMPH NODES EXAMINED (2/7) LEFT LYMPH NODE OF CLOQUET (M) : NO METASTATIC CARCINOMA IDENTIFIED IN TWO LYMPH NODES EXAMINED (0/2) LEFT EXTERNAL ILIAC LYMPH NODES (N): METASTATIC CARCINOMA IDENTIFIED IN THREE OF FOUR LYMPH NODES EXAMINED (3/4) LEFT OBTURATOR LYMPH NODES (O):  NO METASTATIC CARCINOMA IDENTIFIED IN ELEVEN LYMPH NODES EXAMINED (O/11) PRESACRAL LYMPH NODES (P) : NO METASTATIC CARCINOMA IDENTIFIED IN EIGHT LYMPH NODES EXAMINED (O/8) LEFT PROXIMAL URETER (Q: NO HIGH-GRADE UROTHELIAL ATYPIA OR MALIGNANCY IDENTIFIEDS RIGHT PROXIMAL URETER (R) :  NO HIGH-GRADE UROTHELIAL ATYPIA OR MALIGNANCY IDENTIFIEDS PATHOLOGIC TNM STAGE: pT3aN2MX INTRAOPERATIVE DIAGNOSIS: FROZEN SECTION DIAGNOSIS: AFS: Right distal ureter:  no tumor identified BFS: Left distal ureter:  no tumor identified CFS: Apical urethral margin: no tumor identified. GROSS DESCRIPTION: A: The specimen is received fresh from the O.R. and labeled "Right distal ureter F/s." It consists of a segment of ureter measuring 0.3 cm in length by 0.5 cm in diameter. The specimen is entirely submitted for frozen section in cassette AFS. B:  The specimen is received fresh from the O.R. and labeled "Left distal ureter F/s." It consists of a segment of ureter measuring 0.4 cm in length by 0.6 cm in diameter.  The specimen is entirely submitted for frozen section in cassette BFs. C: The specimen is received fresh from the O.R. and labeled "Apical urethral margin F/s." It consists of a fragment of pink-tan soft tissue measuring 1.5 x 1.5 x o.3 cm. The specimen is entirely submitted for frozen section in cassette crs. D  The specimen is received fresh from the O.R. and labeled aurinary bladder & prostate & perivesicle nodes." It consists of a bladder with associated prostate and perivesical fatty tissue measuring overall 26 x 14 x 4 cm..  The peritoneum measures 20 x 10 x 0.8 cm. The bladder measures 9.5 x 7.5 x 2 cm. There is an exophytic mass lesion measuring 1.7 x I x 1.5 cm, located at the mid to left dome, adjacent to the mass lesion, there is an erythematous, ulcerative area measuring
+
+--- Page 3 ---
+Page 3 of 5 Ordere cm Sectioning through the mass lesion reveals the tumor grossly"invades. through the muscularis propria into perivesical fatty tissue.  The uninvolved wall of the bladder measures 0.9 cm in thickness. The left ureter measures 1.5 cm in length by 0.6 cm in circumference, and the right distal ureter measures 3.5 cm in length by 0.6 cm in circumference. The prostate measures 5.5 x 4.5 x 4 cm. The left vas deferens measures 11 cm in length by 0.6 cm in diameter, and the right vas deferens measures 4 cm in length by 0.6 cm in diameter.  The left seminal vesicle measures 3.5 x 2 x 1 cm, and the right seminal vesicle measures 3 x 1.5 x 1 cm. The prostatic urethra measures. in length by 1.7 cm in diameter.. The verumontanum measures 1.5 x 0.6 x 0.4 cm.  The surgical margin is entirely inked black. Multiple candidate perivesical lymph nodes are identified. Representative. sections are submitted in 25 cassettes. E  The specimen is received fresh from the O.R. and labeled "Additional L distal ureter." 'It consists of a segment of ureter with periureteral fatty tissue measuring overall 6 x 3 x 1 cm. The ureter measures 4 cm in length by 0.6 cm in diameter.  Representative sections are submitted in one cassette.. F: The specimen is received in formalin and labeled "Right peri aortic lymph nodes.' It consists of two fragments of yellow-tan soft tissue measuring 3 x 2 x 1 cm. The specimen is entirely submitted in two cassettes.. G: The specimen is received in formalin and labeled "Right common iliac lymph nodes." It consists of multiple fragments of yellow-tan soft tissue measuring 2.5 x 2 x 0.5 cm in aggregate. The specimen is entirely submitted in one cassette. H:  The specimen is received in formalin and labeled "Right external iliac lymph nodes."  It consists of multiple fragments of yellow-tan soft tissue measurimg 5 x 4 x 1.5 cm in aggregate.  Multiple lymph nodes are identified. The largest one. measuring 1.5 cm in greatest dimension. The specimen is entirely submitted in four cassettes. I: The specimen is received in formalin and labeled "Right obturator lymph nodes." It consists of multiple fragments of yellow-tan soft tissue measuring 5 x 3.5 x 2 cm in aggregate. Multiple lymph nodes are identified. The specimen is entirely. submitted in five cassettes. J: The specimen is received in formalin and labeled Right lymph node of cloquet.". It consists of a fragment of yellow-tan soft tissue measuring 4 x 2 x 1 cm in aggregate. Two lymph nodes are identified with the largest one measuring 2 cm in greatest dimension.  The lymph nodes are bisected and the specimen is entirely submitted in one cassette. K: The specimen is received in formalin and labeled "Left peri aortic lymph nodes." It consists of a fragment of yellow-tan soft tissue measuring 3 x 2 x 0.5 cm. The specimen is entirely submitted in one cassette.. L  The specimen is received in formalin and labeled "Left common iliac lymph nodes." It consists of multiple fragments of yellow-tan soft tissue measuring 2 x 2 x 0.5 cm. Multiple lymph nodes are identified. The specimen is entirely submitted in one casssette. M: The specimen is received in formalin and labeled "Left lymph node of cloquet." It consists of a fragment of yellow-tan soft tissue measuring 2.5 x 1.5 x 0.8 cm in. aggregate. Two lymph nodes are identified. The specimen is entirely submitted in one cassette. N: The specimen is received in formalin and labeled "Left external iliac lymph nodes."  It consists of multiple fragments of yellow-tan soft tissue measuring 3 x 3 x 1 cm in aggregate. Multiple lymph nodes are identified with the largest one
+
+--- Page 4 ---
+Page 4 of 5 Colested Ordereg measuring 1.5 cm in greatest dimension. The specimen is entirely submitted in one cassette.  The specimen is received in formalin and labeled "Left obturator lymph nodes.". It consists of multiple fragments of yellow-tan soft tissue measuring 8 x 6 x 2 cm in aggregate.  Multiple lymph nodes are identified with the largest one measuring 2.7 cm in greatest dimension. The specimen is entirely submitted in five cassettes. P:  The specimen is received in formalin and labeled "presacral lymph nodes." It consists of multiple fragments of yellow-tan soft tissue meausring 4 x 2.5 x 1 cm. in aggregate. Multiple iymph nodes are identified. The specimen is entirely. submitted in one cassette. Q: The specimen is received in formalin and labeled sLeft proximal ureter." It consists of a segment of ureter measuring 1 cm in length by 0.3 cm in diameter.. There is one metallic clip located closest to one end of the ureter indicating the. proximal margin. The proximal margin is shaved and entirely submitted in one cassette. R:  The specimen is received in formalin and labeled "Right proximal ureter." It consists of a segment of ureter measuring 1 cm in length by 0.3 cm in diameter.. One metallic clip is noted located closest to the proximal margin.  The proximal  margin is shaved and entirely submitted in one cassette. SECTIONS: AFS: frozen section, right distal ureter BFS: frozen section, left distal ureter cFs: frozen section, apical urethral margin D1-4: tumor with deepest invasion D5: left ureterovesical junction D6: right ureterovesical junction D7: left trigone D8: left lateral D9 : right dome D10: right lateral D11: right trigone D12: right distal prostate D13 : left distal prostate D14: right midprostates D15: left midprostate. D16: right proximal prostate. D17: left proximal prostate D18-25: possible perivesical lymph nodes E: additional left distal ureter. F1,2: right periaortic lymph nodes G: right common iliac lymph nodes H1 : one lymph node, bisected H2-4 : lymph nodes I1-5: right obturator lymph nodes J: right lymph node of Cloquet K: left periaortic lymph nodes L: left common iliac lymph nodes. M: left lymph node of Cloquet N: left external iliac lymph nodes. 01: one lymph node, bisected 02-5: lymph nodes P: presacral lymph nodes Q: left proximal ureter R: right proximal ureter
+
+--- Page 5 ---
+Page 5 of 5 MICROSCOPIC DESCRIPTION: A-C: See microscopic-diagnoses D: Sections of the exophytic mass lesion and adjacent ulcerated lesion seen grossly on the mid to left dome region correspond histologically to invasive. transitional cell carcinoma (D2, D3, D4).  The neoplastic cells have high NC ratio. with large pleomorphic hyperplastic nuclei and are arranged in solid sheets and. single cells.. Extensive desmoplastic change is seen. The tumor extends through. the muscularis propria into the perivesical soft tissue to involve the peritoneum.. Multiple satellite tumor nodules are identified in the perivesical soft tissue.. No carcinoma in situ is identified. Extensive lymphovascular space invasion is seen.. Sections of the prostate show focal prostatic intraepithelial neoplasm (pin II and. III) characterized by hyperplastic glands lined by stratified layers of enlarged cells with corresponding large nuclei and variable prominent nucleoli.. E-R: See microscopic-diagnoses. Signed by: ELECTRONIC SIGNATURES POST-OPERATIVE DIAGNOSIS: Same PRE-OPERATIVE DIAGNOSIS: Same ORDERING PHSYCIAN: Ordering Physician:.
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diff --git a/output/text/a72a1c5a-0590-4195-ae9e-7f9225acf97e.txt b/output/text/a72a1c5a-0590-4195-ae9e-7f9225acf97e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..cfee2642e8b2e31488c62490bd02629a0314f7b7
--- /dev/null
+++ b/output/text/a72a1c5a-0590-4195-ae9e-7f9225acf97e.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SURGICAL PATHOLOGY REPORT SPECIMEN Right colon. CLINICAL NOTES PRE-OP DIAGNosIS: Right colon cancer. GROSS DESCRIPTION Received fresh labeled "right colon" is a previously unopened, 29 cm.  segment of proximal right colon with attached 10 cm. of distal ileum surfaced by smooth to scabrous tan. pink serosa with a copious amount of attached mesocolon and. mesentery. An unremarkable 6.2 cm. in length, 0.3 cm. in diameter appendix is present. The proximal and distal margins measure 3.2 and 5.6 cm. in circumference respectively.  On opening, there is a well mscribed 5.2 x 4.0 cm. rubbery pale tan tumor located 3.8 cm. distal to the ileocecal valve.  The tumor has the maximal thickness of 1.2 cm., grossly extending into the muscularis propria, to within 0.2 cm. of the inked free radial serosal surface. A portion of tumor and a portion of normal mucosa are submitted for. tissue procurement as requested. mucosa are unremarkable tan pink with regular folds and the walls average 0.5 cm. in thickness. Several slightly rubbery tan white tissues in keeping with lymph nodes measuring up to 1.4 cm. greatest dimension are recovered from the attached mesocolon and mesentery. Representative sections are submitted in 12 blocks as. labeled. BLOCK suMMARy: 1 - proximal and distal margins; 2 through 4 - tumor full thickness to inked radial serosal surface (black); 5 - tumor to distal normal mucosa; 6 - Icv; 7 - random colon; 8 - appendix; 9. six whole lymph nodes; 10 - four wh lymph nodes; 11 and 12 - one bisected lymph node per cassette MICROSCOPIC DESCRIPTION Histologic type: Adenocarcinoma Histologic grade: Moderately-differentiated Primary tumor (pT2): Carcinoma into, but not completely through, the muscularis propria. Proximal/distal/radial margins: Negative. Vascular invasion: Negative. Regional lymph nodes (pN) : Twelve negative lymph nodes (0/12). Non-lymph node pericolonic tumor: Not identified. Other findings:  appendix with fibrous luminal obliteration; ileum unremarkable.
+
+--- Page 2 ---
+DIAGNOSIS Terminal ileum, cecum, appendix, proximal colon, right. hemicolectomy: Adenocarcinoma, moderately-differentiated, with invasion into, but not through, the muscularis propria. Negative margins of excision.. Angiolymphatic invasion not identified.. Twelve negative lymph nodes (0/12).. End Of Report.
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diff --git a/output/text/a73cf203-c35c-42bf-9a5b-c6defafb0045.txt b/output/text/a73cf203-c35c-42bf-9a5b-c6defafb0045.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4c7f576c7d5a6bc0398f52b41ab241830f1d86b8
--- /dev/null
+++ b/output/text/a73cf203-c35c-42bf-9a5b-c6defafb0045.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SURGICAL PATHOLOGY: PROCEDURF DATE: RECEIVED DATE: REPORT DATE COPY TO: Pre-Op Diagnosis Colon cancer Post-Op Diagnosis Same as above Clinical History Nothing indicated Gross Description: Container labeled " - right colon" is an approximately 14 cm previously opened moderately distorted portion of large bowel including cecum, as well as 4.5 cm of previously opened terminal ileum. The specimen is covered by a moderate amount. of pericolic and epiploic adipose tissue in which a 4.3 x 0.6 x 0.6 grossly unremarkable vermiform appendix is identified. The visible. serosa is shaggy and gray-brown with several fibrofatty adhesions. The wall is up to 0.6 cm edematous and fibrotic. The lumen is lined by gray-tan mucosa with preservation of intestinal folds and a small amount of submucosal edema. Noted within the cecal pouch at a point 0.3 cm from the ileocecal valve there is a previously sectioned moderately distorted fairly well defined approximately 3.0 x 2.8 cm centrally ulcerated finely granular tan brown plaque like lesion with slightly raised rolled borders. This appears to have a gritty gray-tan fibrotic cut surface measuring up to 0.7 cm in thickness This grossly appears to focally extend through the wall focally shallowly into the surrounding adipose tissue adjacent to the ileocecal valve. In addition, this lesion focally appears to extend into the appendiceal orifice but does not grossly appear to obstruct the appendix. On sectioning, the surrounding adipose tissue shows several poorly defined gray tan to brown nodules up to 0.6 cm. Also. received in the same container are three tissue cassettes each labeled 1  Representative sections are submitted Iabeted as follows: A - proximal margin; B - dista! margin with a portion of proximal margin included; C-F - representative lesion and
+
+--- Page 2 ---
+surrounding tissue; G - random uninvolved bowel; H - representative more distal aspect of appendix; I - appendix near appendiceal. orifice; J-L - nodules from pericolic fat. Microscopic Description: The slides labeled! are examined. See diagnosis Final Diagnosis Tumor characteristics: Histologic type: Adenocarcinoma. Location of tumor: Cecal pouch. Size: 3.0 x 2.8 x 0.7 cm in greatest dimension. Grade: Poorly differentiated. Lymphovascular space invasion: Yes. Perforation of Visceral peritoneum: No Presence of mesenteric deposits: No. Depth of invasion: Carcinoma extends through muscularis propria into subserosal adipose tissue. Surgical Margin Status: Proximal Margin: No carcinoma identified. Distal Margin: No carcinoma identified. Radial Margin: No carcinoma identified. Distance of tumor from closet margin: Carcinoma extends to within 1 mm of the serosal surface but does not perforate or extend to the serosal surface. Lymph Node Status: Total number of lymph nodes examined: 17 Total number of lymph nodes with metastatic carcinoma: 1 (1/17) PAS 9 Appendix: Fibrous obliteration of the lumen. PAS 4 SPC-A CPT: 88309 Stage: pT3N1a Comments At the request of the undersigned pathologist, these slides have. been additionally reviewed by Dr.   who concurs with the diagnosis. This test has been finalized at the  Campus. <Sian Out Dr. Signature>
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diff --git a/output/text/a7419cea-f700-4ed0-bd26-dbc96140f3d1.txt b/output/text/a7419cea-f700-4ed0-bd26-dbc96140f3d1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d38b524874985fab1c440338927b81df7687d113
--- /dev/null
+++ b/output/text/a7419cea-f700-4ed0-bd26-dbc96140f3d1.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis: Colon resection material includes a mucinous, moderately differentiated adenocarcinoma of the colorectal type, showing circular growth and measuring a maximum of 5 cm in diameter with widespread infiltration of the pericolic fatty tissue and with five regional lymph node metastases. Tumor-free colon resection margins. Close to one resection margin a clip-marked mucosal defect with florid inflammatory lesions and fibrin insudation of the submucosa, evidently in status post excision of a polyp or a neoplasia (see previous finding. Tumor stage: pT3 pN2 (5/30) M1 (clinically liver metastases); G2, L0, V0, clinically R2
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diff --git a/output/text/a751d949-f546-49a1-8d8e-0cbe4d0e6e37.txt b/output/text/a751d949-f546-49a1-8d8e-0cbe4d0e6e37.txt
new file mode 100644
index 0000000000000000000000000000000000000000..bb970c098a943971060fe7b9882dafcea25a961e
--- /dev/null
+++ b/output/text/a751d949-f546-49a1-8d8e-0cbe4d0e6e37.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+ID o 3 UUID:8A8CB301-B3F2-469B-85D3-CAEA5A2F46ED -01A-PR Redacted Corcinsme, hepatselOuloer NoS 817013 Site sLuie Cn5.O. CLINICAL DIAGNOSIS: HCC QJ s/91i4 Specimen : liver Gross Photo : GROSS: Specimen status: Fresh Operation: Central bisectionectomy Organ: Liver (15.0 x 11.0 x 5.5 cm, 477.0 gm) Gallbladder (8.0 cm in length, 3.0 cm in diameter). [Liver] Lesions: Huge hepatic mass - Size: 8.8 x 7.5 x 6.8 cm - Cut surface: Relatively well-demarcated, yellowish tan, round and solid - Gross type: Multinodular confluent - Extent: Confined to the capsule, grossly - Resection margin: Not involved, grossly (safety margin: 0.5 cm). Remaining parenchyme: Unremarkable, grossly [Gallbladder] Serosal surface: Yellowish green and smooth Mucosal surface: Dark geen and velvety, no mural nodule. Wall: 0.2 cm in thickness Representative sections are submitted. Gross photo: Present Blocks T1-4, mass of liver x 4 RM, tumor with resection margin x 1 L, nontumorous liver parenchyme x 1 LN, labeled as '12' x 1 GB1-2, gallbladder x 2 MICROSCOPIC: Tumor type: Hepatocellular carcinoma The worst differentiation IV The major differentiation IV Histologic type: Trabecular and tubular Cell type: Hepatic. Fatty change: No. Cholangiocarcinoma: No Fibrous capsule formation: Yes Capsular infiltration with gallbladder invasion: Yes. Septum formation: Yes
+
+--- Page 2 ---
+Surgical resection margin invasion: Very close to resection marign (less than O.1 cm) Serosal invasion: No Portal vein invasion: No Vascular invasion: Yes Bile duct invasion: No NOT reported. Gross: Peritoneal fluid, smear, inflammation Peritoneal fluid, smear, inflammation Peritoneal fluid, smear, inflammation Peritoneal fluid, smear, inflammation Peritoneal fluid, smear, inflammation liver,ectomy,hepatocellular carcinoma T56000, P10, M81703 gallbladder,ectomy,direct tumor extension,lymphovascular emboli from liver present. T57000, P10, MDTE, lymphovascular emboli from liver present lymph node,biopsy,no tumor TO8000, P50, M09450 DIAGNOSIS: Liver, segment 4, 5, and 8, central bisectionectomy: Hepatocellular carcinoma Gallbladder, cholecystectomy: Direct tumor extension from liver Lymphovascular emboli from liver present Lymph node, '12', biopsy: No tumor present (0/1) Suggestion :
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diff --git a/output/text/a7559ae7-60e5-43b2-9075-389b0aec7044.txt b/output/text/a7559ae7-60e5-43b2-9075-389b0aec7044.txt
new file mode 100644
index 0000000000000000000000000000000000000000..091a0d2d3c51247933a23d7190cc83d2f796523f
--- /dev/null
+++ b/output/text/a7559ae7-60e5-43b2-9075-389b0aec7044.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+icd-o-3 cgrcinoma,inf1haHng duc1,Ns 8 800J3 UUID:5018EC57-96C6-4D63-8708-4555984D8527 TCGA-A2-A3XU-01A-PR Redacted Sik: bregs+, N0s c 50.9 5-z3-iz rp SURGICAL PATHOLOGY REPORT Name: Lab No.: Date: Sex: M.R. No.: Age: Hosp No.: Doctor: Room No: CLINICAL HISTORY: PREOPERATIVE DIAGNOSIS: Left Breast Cancer POSTOPERATIVE DIAGNOSIS: OPERATION: Left Brcast SPECIMEN: (A) Left Breast Lumpectomy (Gross Margins) 2 Short Anterior, 1 Long Lateral, 1 Short Superior, (IB) Frozen Section Left Axillary Sentinel Node #]. (C) Frozen Section Sentinel Node #2, (D) Frozen Scction Sentinel Node #3, (E) Frozen Section Sentincl Node #4, (F) Frozen Section Sentinel Node #5, (G) Frozen Section Sentinel Node #6, (H) Additiona! Anterior Margins, Suture on New Anterior Margins (1) Additional Inferior/Lateral Margins, Short Suture on Inferior, Long Suture on New. Lateral, (J) Axillary Contents FROZEN SECTION DIAGNOSIS: A -- TUMOR MEASURES 4.6CMS IN GREATEST DIMENSION GROSSLY VERY CLOSE TO ANTERIOR, INFERIOR  LATERAL MARGINS (ABOUT 0.1CM.) THE REMAINING SURGICAL MARGINS ARE ABOUT 0.2-0.5CM. TO TUMOR MASS GROSSLY B -- ONE NEGATIVE NODE (0/1) -- C - ONE NEGATIVE NODE (0/1) - D -- ONE POSITIVE NODE (1/1) E - ONE NEGATIVE NODE (0/1) -- F - ONE NEGATIVE NODE (0/1) - G - FOR PERMANENT SECTION ONLY H - GROSSLY FREE OF TUMOR I - GROSSLY FREE OF TUMOR
+
+--- Page 2 ---
+PAGE 2 SURGICAL PATHOLOGY REPORT FINAL DIAGNOSIS: (A) LEFT BREAST LUMPECTOMY FOR GROSS MARGINS - INFILTRATIVE DUCTAL CARCINOMA (4.5CMS) - SCARFF-BLOOM-RICHARDSON GRADING: GRADE III OF III (ABSENT TUBULE FORMATION/HIGH GRADE NUCLEAR FEATURES/HIGH MITOTIC INDEX) - DCIS: NONE IDENTIFIED - ANGIOL YMPHATIC INVASION: PRESENT, MULTIFOCAL - SURGICAL MARGINS: FOCAL INVOLVEMENT OF SUPERIOR MARGIN (0.1CM) (B) FROZEN SECTION LEFT AXILLARY SENTINEL NODE #1 - ONE BENIGN REACTIVE LYMPH NODE (0/1) (C) FROZEN SECTION SENTINEL NODE #2 POSITIVE FOR MICROMETASTASES (1MM, 1/1) (D) FROZEN SECTION NODE #3  POSITIVE FOR MICROMETASTASES (1MM, 1/1) (E) FROZEN SECTION SENTINEL NODE #4  POSITIVE OR MICROMETASTASES (IMM, 1/1) (F) FROZEN SECTION SENTINEL NODE #5 ONE BENIGN REACTIVE LYMPH NODE (0/1) (G) FROZEN SECTION SENTINEL NODE #6 ONE BENIGN REACTIVE LYMPH NODE (0/1) (H) ADDITIONAL ANTERIOR MARGINS BENIGN BREAST TISSUE
+
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+PAGE 3 SURGICAL PATHOLOGY REPORT (I) ADDITIONAL INFERIOR/LATERAL MARGINS BENIGN BREAST TISSUE WITH FIBROCYSTIC CHANGES TO INCLUDE FOCAL ADENOSIS EXHIBITING SECRETORY ACTIVITY (J) AXILLARY CONTENTS  SIX BENIGN REACTIVE LYMPH NODES (0/6) pTNM Classification: T2, N1mi, MX, STAGE GROUPING IIB COMMENT: The tumor exhibits epitheloid features and focal mucinous differentiation with infiltrating and pushing borders. BREAST CANCER PROGNOSTIC PROFILE WILL BE PERFORMED ON BLOCK A7 AND WILL BE REPORTED IN AN ADDENDUM. PATHOLOGIST- GROSS: Specimen A is received fresh unfixed Iabeled *Left Breast Lumpectomy for Gross Margins which are obtained by Dr. . Specimen consists of a 46 gram ovoid mass of apparent fatty and fibrous encased tissue which measures 4.5 x 3 x 2.5 cm. in greatest overall dimension. There is a single short suture indicating superior margin inked with a red dye. #=# 9 bIocks. KEY NOTE BLOCK SUMMARY: AI - Lateral A2 -- Medial A3 - Anterior
+
+--- Page 4 ---
+PAGE 4 SURGICAL PATHOLOGY REPORT A4 -- Posterior A5 -- Superior A6 -- Inferior A1 to A6 : ALL PERPENDICULAR MARGINS A7 to A9 -- Random.. Specimen B is rcceived fresh unfixed labeled "Frozen Section Left Axillary Sentinel Node #1 for Frozen Section" and consists of an irregular mass of tan gray firm rubbery tissue Frozen measuring 0.6 x 0.3 x 0.4 cm. in greatest overall dimension. Scctioned by Dr. sections are obtained by Dr. Entire specimens including frozen section. 2 blocks.. Specimen C is received fresh unfixed labeled "Frozen Section Sentinel Node #2" and. consists of an ovoid mass of pink tan firm rubbery tissuc measuring 0.8 x 0.4 x 0.3 cm. TOUCH Frozen section is obtained by Dr. Specimcns are sectioned by Dr. PREP is obtained by Dr.. . Entire specimens including Frozen Section 2 blocks.. Speclmen D is received fresh unfixed Iabcled "Frozen Section Node #3" and consists of an ovoid mass of pink tan firm rubbery tissue measuring 0.4 x 0.3 x 0.2 cm. in greatest overall dimension. Sectioned by Dr. Frozen Scction is obtained. Entire specimens including. Frozen Section 2 blocks.. Specimen E is received fresh unfixed labeled "Frozen Section Scntinel Node #4"' and consists of an ovoid mass of tan gray firm rubbery tissue 1 x 0.6 x 0.3 cm. in greatest overall Entire dimension. Specimen is sectioned. Frozen Section is obtained by Dr. ! specimen including Frozen Section 2 blocks. Specimen F is received fresh unfixed labeled "Frozen Scction Sentinel Node #5" and. consists of irregular fragments of pink tan firm rubbery tissue mcasuring 0.3 cm. x 0.3 x Entire specimensd 0.3 cm. Specimen is sectloned. Frozen section is obtained by Dr. including Frozen Section 2 blocks. Specimen G is received fresh unfixed labeled Frozen Section Sentinel Node #6' and consists of an ovoid mass of tan gray firm rabbery tissue measuring 1.0 x 0.4 x 0.3 cm. in
+
+--- Page 5 ---
+PAGE 5 SURGICAL PATHOLOGY REPORT greatest overall dimension. Frozen section is deferred by Operating Room. Entire spectmcn. 2 blocks. Spccimen H is received fresh unfixed Iabeled "Additional Anterlor Margins" and consists of an 11 gram irregular mass of tan gray fatty tissue measuring 3 x 2 x 1 cm. in greatest overall dimension. Specimen is inked by Dr.. Gross margins are obtained by Dr.. 2 sectlons. Speclmen I is received fresh unfixed labelcd "Additional Inferior/Lateral Margins? and consists of an 18 gram irregular mass of apparent fatty tissue which measures 4 x 3 r 2 cm. in greatest overall dimension. There is a short sature indicating inferior margin and inked with yellow dye, and a long suture indicating new lateral margin, inked with a green dye. Sectloning reveals gray white fibrous tissue admixed with adipose tissue. Gross margins are obtained by Dr. . 4 blocks. J. Specimen is received fixed and labeled "axillary contents' and consists of rare, firm, tan- grey uodules varying up to 0.8cm in greatest dimension. The Iargest is trlsected and placed in cassette J3. Three blocks.. MICROSCOPIC EXAMINATION CONDUCTED BY PATHOLOGIST CONFIRMS FINAL DIAGNOSIS
+
+--- Page 6 ---
+SURGICAL PATHOLOGY REPORT Name: Lab No.: Sex: Date: Age: M.R. No.: Doctor: Hosp No.: Room No: CLINICAL HISTORY: PREQPERATIVE DIAGNOSIS: Left Breast Cancer POSTOPERATIVE DIAGNOSIS: OPERATION: Left Breast SPECIMEN: (A) Left Breast Lumpectomy (Gross Margins) 2 Short Anterior, 1 Long Lateral, 1 Short Superior, (B) Frozen Section Left Axillary Sentinel Node #1 (C) Frozen Section SentineI Node #2, (D) Frozen Section Sentinel Node #3, (E) Frozen Section Sentinel Node #4, (F) Frozen Section Sentinel Node #5, (G) Frozen Section Sentinel Node #6, (H) Additional Anterior Margins, Suture on New Anterior Margins (1) Additlonal Inferior/Lateral Margins, Short Suture on Inferior, Long Suture on New Lateral, (J) Axillary Contents ESTROGEN AND PROGESTERONE RECEPTOR RESUL TS: ESTROGEN RECEPTOR RESPONSE: NEGATIVE PROGESTERONE RECEPTOR RESPONSE: NEGATIVE
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+TSS IC 1cs-0-3 SPECIMENS: Carcinona nfiPtratvg lobulery nos 8520|3 A. SENTINEL NODE #1 LEFT AXILLA B. SENTINEL NODE #2 LEFT AXILLA C. LEFT BREAST MASS WITH NEEDLE LOCALIZATION CQcF : Sih brast,N0s c50 9 /8/ D. ADDITIONAL MARGIN LEFT BREAST SPECIMEN(S): A. SENTINEL NODE #1 LEFT AXILLA B. SENTINEL NODE #2 LEFT AXILLA UUID : 12DAEBF2-CD6F-4D90-9C74-2A2AEF1E8433 C. LEFT BREAST MASS WITH NEEDLE LOCALIZATION TCGA-E2-A1IH-01A-PR Redacted D. ADDITIONAL MARGIN LEFT BREAST GROSS DESCRIPTION: A. SENTINEL NODE #1 LEFT AXILLA Received fresh is a tan pink lymph node 1.5 x 1.0 x 0.7cm. The specimen is serially sectioned and one touch prep is taken. Toto A1. B. SLN #2 LEFT AXILLA Received fresh is a tan pink lymph node 1.0 x 0.7 x 0.5cm. The specimen is serially sectioned and one. touch prep is taken. Toto B1 C. LEFT BREAST NEEDLE LOCALIZATION Single stitch: Anterior Double stitch: Lateral Triple stitch: Superior Received fresh is a 79g oriented WLE breast specimen 2.5cm from anterior to posterior, 7.5cm from superior to inferior and 8.5cm from medial to lateral, with needle localization wire and attached. radiograph. The specimen is inked as follows: Anterior-Blue, Posterior-Black, Superior-Red, Inferior- Orange, Mediai-Green, Lateral-Yellow. The specimen is serially sectioned from lateral to medial in to 8 slices: slice 1 being most medial, slice 8 being most lateral. The cut surfaces reveal a gray white firm well circumscribed mass 1.5 x 1.0 x 0.8cm, 0.6cm from the closest deep margin, 0.7cm from the anterior margin and 0.8cm from the medial margin. The mass is located in slice 2 and 3. The remaining cut surfaces reveal yellow lobulated adipose tissue interdispersed with gray white fibrous tissue. A portion of the specimen is submitted for tissue procurement. Representative sections are submitted as follows: C1-C5: medial margin perpendicular sections from superior to inferior slice 1 C6: superior margin slice 2 C7: mass with anterior and deep margin slice 2 C8: inferior margin slice 2 C9: superior margin slice 3. C10: mass with anterior margin slice 3 C11: mass with deep margin slice 3 C12: inferior margin slice 3 C13: next to mass with anterior margin slice 4 C14: next to mass with deep margin slice 4 C15: slice 5 C16: lateral margin perpendicular sections slice 8 As per attached diagram.. D. ADDITIONAL MEDIAL MARGIN LEFT BREAST: Stitch at new margin Received fresh is a 4g oriented tan pink fragment of fibrofatty tissue 5.0 x 2.0 x 1.0cm. The new true margin is inked Black and the specimen is serially sectioned to reveal grossly unremarkable breast parenchyma. Toto D1-D4. DIAGNOSIS: A. LYMPH NODE, SENTINE# 1, LEFT AXILLA, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1). B. LYMPH NODE, SENTINE# 2, LEFT AXILLA, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1). C. BREAST, LEFT, WIDE LOCAL EXCISION: - INVASIVE, LOBULAR CARCINOMA, SBR GRADE 2, MEASURING 1.5 CM - SURGICAL MARGINS ARE NEGATIVE FOR TUMOR - SEE SYNOPTIC REPORT AND SEE NOTE.
+
+--- Page 2 ---
+TSS iD ! D. BREAST, LEFT, ADDITIONAL MEDIAL MARGIN, EXCISION: - BREAST TISSUE, NO TUMOR SEEN. NOTE: The tumor is negative for E-cadherin, compatible with lobular phenotype. SYNOPTIC REPORT - BREAST Specimen Type: Excision Needle Localization:. Yes - For mass Laterality: Left Invasive Tumor: Present Multifocality: No WHO CLASSIFICATION Invasive lobular carcinoma 8520/3 Tumor size: 1.5cm Tumor Site: Upper inner quadrant Margins:  Negative Tubular Score: 3 Nuclear Grade: 2 Mitotic Score: 1 Modified Scarff Bloom Richardson Grade:. 2 Necrosis: Absent Vascular/Lymphatic Invasion: None identified. Lobular neoplasia: None Lymph nodes:  Sentinel lymph node only Lymph node status: Negative 0/2 DCIS not present ER/PR/HER2 Results ER: Positive PR: Positive HER2: Pending by FISH Pathological staging (pTN): pT 1c N 0 SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimen:  Surgical Excision Block Number: Allred Score: 8 = Proportion Score 5 + Intensity Score 3 ER: Positive Allred Score: 8 = Proportion Score 5 + Intensity Score 3. PR: Positive COMMENT: The Allred score for estrogen and progesterone receptors is caiculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring  range from 0 to 8. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2. METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Immunohistochemistry was performed using the mouse anti-human ER (ER 1D5, 1:100) and PR (PGR following the manufacturer s instructions. This 136, 1:100) provided by assay was not modified. Interpretation of the ER/PR immunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal review of staining performance.
+
+--- Page 3 ---
+TSS ID SYNOPTIC REPORT - BREAST HER-2 RESULTSE Specimen:  Surgical Excision Block Number: Interpretation: EQUIVOCAL Intensity: 2+ % Tumor Staining: 20% Fish Ordered: Yes. METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Her2 analysis was performed using the FDA approved Dako HercepTest (TM) test kit using rabbit anti-human HER2. This assay was not modified. External kit-slides provided by the manufacturer (cell lines with high, low and negative HER2 protein expression) and in- house known HER2 amplified control tissue were evaluated along with the test tissue. Adequate, well preserved, clear-cut invasive carcinoma was identified for HER2 evaluation. Interpretation of the HER2 immunohistochemical stain is guided by published results in the medical literature, information provided. by the reagent manufacturer and by internal review of staining performance. This assay has been validated according to the 2007 joint recommendations and guidelines from ASCO and CAP and from the NCCN HER2 testing in Breast Cancer Task Force.  takes full responsibility for this test's performance.. CLINICAL HISTORY: woman with Left Breast Ca: Invasive Ductal 11 o'clock. 1.7cm on mammogram. PRE-OPERATIVE DIAGNOSIS:  Left Breast Ca INTRAOPERATIVE CONSULTATION: TPA/TPB: Negative for tumor. Diagnosis called to Dr at. C. GROSS INSPECTION: 1.5cm mass. 0.6cm from the closest deep margin, 0.7cm from anterior Jy Dr. margin. Diagnosis called to Dr. at D. GROss iNSPECTION: New medial margin. Negative for tumor. Diagnosis called to Dr. at by Dr. Dr. 1 by ADDENDUM: FISH for HER-2 amplification for this case was attempted multiple times using multiple blocks from this case. In each instance the tissue would not remain on the slide for analysis. As a result of this one block will be sent to another laboratory for further testing.. This case was sent to the for second opinion for HER-2 FISH. The results reported below are the. verbatim results of this referral. HER2 Amp. Breast Cancer. FISH Specimen Tissue-Paraffin Specimen ID Source Left breast Order Date  Reason For Referral. r/o HER2 gene amplification Fixative Formalin Method: FISH using probes for HER2 (17q12) and a chromosome 17 centromere (D17Z1) control probe (PathVysion, Two technologists score signals in 60 total nuclei from invasive or metastatic tumor and concurrent controls. Results: nuc ish (D17Z1x2, Her2x3-5) The HER2 to D17Z1 ratio is 2.28 Interpretation: The invasive tumor nuclei have an amplified HER2D17Z1 ratio (per ASCO/CAP
+
+--- Page 4 ---
+TSS ID  guidelines). The HER2D17Z1 ratio is 2.28. In our opinion, this result may not. reflect true HER2 amplification. Most nuclei have 2 copies of the chromosome 17 centromere and 3-5 copies of the HER2 gene. This result indicates the tumor has additional copies of the HER2 gene (i.e., duplication), but does not have sufficient copies to suggest high level HER2 amplification. It is not known if HER2 duplication is associated with HER2 over-expression in breast adenocarcinoma. ASCO/CAP reporting guidelines (Wolff et al, Arch Path Lab Med 131:18-43, 2007).. A HER2D17Z1 ratio less than 1.8 indicates absence of HER2 gene amplification. A HER2D17Z1 ratio from 1.8-2.2 is equivocal for HER2 gene amplification. A HER2D17Z1 ratio greater than 2.2 indicates HER2 gene amplification. DiSCLAlMER: This test was developed and its performance characteristics determined by Laboratory Medicine and Pathology, It is intended as. an adjunct to existing prognostic clinical and pathologic information for breast cancer patients. This test is not intended to diagnose or screen for breast cancer. Per ASCO/. CAP guidelines, HER2FiSH test results are valid for non-decalcified paraffin embedded. specimens fixed in 10% neutral buffered formalin between 6 and 48 hours. Results from. specimens fixed outside these parameters should be interpreted accordingly. Consultant Report Data Gross Dictation: M.D., Pathologist,. Microscopic/Diagnostic Dictation: M.D., Pathologist, ' Microscopic/Diagnostic Dictation: M.D., Pathologis!. Final Review: M.D., Pathologist,. Final:, M.D., Pathologist,. Addendum:  M.D., Pathologist, Addendum Final:  M.D., Pathologist, 1. Addendum: M.D., Pathologist. Addendum Review:M.D., Patnoiogi: Addendum Final: M.D., Pathologist,.
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diff --git a/output/text/a7833d4d-c62c-4557-8efe-cac60fd4c60e.txt b/output/text/a7833d4d-c62c-4557-8efe-cac60fd4c60e.txt
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+Clinical Diagnosis & Hiatory: Adenocarcinoma of colon. Specimens Submitted: 1: Sp: Colon, right; segmental regection 2: sp: Omentum; omentectomy DIAGNOSIS: I. Sp: Colon, right; segmental resection: Tumor Type: Adenocarcinoma with mucinous features (<s0%-mucinoua component). Histologic Grade:. Moderately differentiated. Tumor Location:. Cecum Size: Length is 5 cm Width is 8 cm Maximal thickness is 0.4 cm Tumor Budding: Absent Increased Tumor Infiltrating Lymphocytes: Absent. Precursor Lesions: Tubulovillous adenoma Deepest Tumor Invasion: Subserosal adipose tisaue and/or mesenteric fat Tumor is geen within I mm of the serosal surface in an area of serositis Gross Tumor Perforation: Not identified Lymphovascular Invasion: Not identified Large Venous Invasion: Not Identified. Perineural Invasion:d Identified Surgical Maxgins:. Free of tumor Polyps/Mucosa Dysplasia (away fxom the carcinoma) : ** Continued on next page ** +x
+
+--- Page 2 ---
+Page 2 of 3 Not Identified Non-Neoplastic Bowel: Unremarkable Appendix: Not identified Lymph Nodea: Number with metastasis: 0 Total number examined: 28 Tunor deposits in pericolorectal soft tissue: Not Identified unor Staging (AJcc 7th Edition): pT3 (Tumor invades through the muscularis propria into pericolorectal tigsues) Lymph Node Stage (Aucc 7th Edition): N0 (No regional lymph node metastasis) 2. OMENTUM; OMENTECTOMY: BENIGN MATURE ADIPOSE TISSUE. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APFROVED THIS REPORT. 1). The specimen is received fresh, labeled "Right colon" and consists of a segment of terminal ileun, cecum, and ascending colon. The appendix is not grossly identified. The terminal ileum measures 12 cm in length and 4 cm in circumference at the proximal resected margin. The remaining colon measures 23 in length with a circumference of 7.2 cm at the distal resected margin. The intestinal serosa is pink tan and smooth. Focally hemorrhagic lobulated yellow tan adipose tigsue spans the length of the specimen measuring up to 5.5 cm in thickneas. The specimen is opened to reveal a friable, polypoid mass leaion measuring 5.0 cm in length and 8,0 cm in width. The mass is located in the large intestine, 14 cm from the proximal margin and 20 cm from the distal margin. Sectioning ahows that the tunor grossly invades through the muscularis and involvea the underlying adipose tissue, and 1.5 cm from the ileocecal valve. The depth of invasion is 0.4 cm grossly. The ileocecal valve is granular and markedly edematous. The remaining mucosa is tan-brown with the normal fords. The attached adipose tissue is submitted fox lymph node dissection. Representative sections of the specimen are submitted for permanent sections and for Tes. Sumary of sections:  - proximal margin shave D - distal margin shave.
+
+--- Page 3 ---
+Page 3 of 3 tumor I--ileocecal valve Rs -representative sections LN - Iymph nodes BLN - bisected lymph nodes 2). The specimen is received fresh, labeled "Omentum." It consista of a 24 x. 8.5 x 0.s cm portion of lobulated adipose tisaue consistent with omentum. Serial sectioning reveals a yellow lobulated surface. No lymph nodes are. groasly identified. Representative sections are submitted. Summary of sections: O - omentum Summary of Sections: Part 1: SP: Colon, right; segmental resection Block Sect. Site PC 2 DM 4 1 10 LN 24 rt 4 PM 2 RS 11 Part 2: SP: Omentum; omentectomy Block Sect. Site PCg 3 6 End of Report.
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diff --git a/output/text/a78a973a-c42f-4851-a63f-1660ae931439.txt b/output/text/a78a973a-c42f-4851-a63f-1660ae931439.txt
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index 0000000000000000000000000000000000000000..c6b1dfcbdaea29f7eabcfb8a3396b733c558d739
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+1CS-0-3 TSS Cauciomt, iifilt^stry ducte, Nos 8500/3 SPECIMENS: CQlF SFh bunt,nos c5o.9 A. ADDITIONAL AXILLARY NODES 2/15/1 B. LEFT BREAST WITH AXILLARY CONTENTS LEVELS 1 & 2 SPECIMEN(S): A. ADDITIONAL AXILLARY NODES B. LEFT BREAST WITH AXILLARY CONTENTS LEVELS 1 & 2 GROSS DESCRIPTION: A. ADDITIONAL AXILLARY NODES LEFT  Received in formalin are multiple tan-pink fragments of fibrofatty tissue aggregating to 4.0 x 4.0 x 2.0 cm. Dissection reveals 7 possible lymph nodes ranging from 0.2 x 0.2 x 0.2 cm to 2.0 x 1.5 x 1.5 cm. A1: 4 possible lymph nodes A2: 4 possible lymph nodes A3: 2 possible lymph nodes A4-A5: 1 lymph node serially sectioned. B. LEFT BREAST WITH AXILLARY CONTENTS LEVELS 1 & 2 Received fresh is a 2,422 gm oriented radical mastectomy specimen, 31 x 27 x 10 cm. The specimen is partially surfaced with a tan-brown ellipse of skin, 27 x 14.5 cm. The centrally located darkened areola rim measures 3.0 cm and the partially flattened nipple measures 1.0 cm. The skin surface is. remarkable for a gray-white linear well healed scar, 3.5 cm in length and measuring 6.0 cm from the nipple in the upper outer quadrant. The specimen is inked as follows: anterior/superior-blue, anterior/inferior-orange, posterior-black. The specimen is serially sectioned from medial to lateral into 13 slices; slice 1 being most medial, slice 13 being most lateral. The nipple is located in slice four. The cut surface reveals a gray-white firm/necrotic ill defined mass located in the upper outer central outer quadrant in slice 6, 7 8 and 9, measuring 0.6 cm from the closest deep margin. The mass measures 9.0 x 8.0 x 4.0 cm, and corresponds to the scar on the skin surface. The remainder of the specimen reveals yellow lobulated adipose tissue interdispersed with gray-white fibrous tissue. The axillary tail  measures 8.0 x 5.0 x 4.0 cm. Dissection reveals 27 possible lymph nodes ranging from 0.1 x 0.1 x 0.1 cm to 2.0 x 1.5 x 1.5 cm. Slice 11 and 12 are remarkable for 3 large firm lymph nodes, ranging from 1.0 x 0.8 x 0.8 cm to 5.0 x 2.0 x 2.0 cm. Portion of the specimen is submitted for tissue procurement. Representative sections are submitted as follows:. B1: 1 lymph node, serially sectioned slice 11 B2-B5: 1 lymph node, serially sectioned slice 11 & 12. B6-B12: 1 lymph node, serially sectioned slice 11 & 12. B13: 5 possible lymph nodes B14: 4 possible lymph nodes B15: 5 possible lymph nodes B16: 4 possible lymph nodes UUID:3327975F-94BE-460E-9900-E063340927BE B17: 3 possible lymph nodes TCGA-E2-A1LL-01A-PR Redacted B18: 2 possible lymph nodes B19: 2 possible lymph nodes B20: 1 lymph node, trisected B21-B22: 1 lymph node, serially sectioned B23-B24: nipple serially sectioned slice 4 B25: base of nipple slice 4 B26: scar with skin slice 7 B27: upper inner quadrant slice 2 B28: upper inner quadrant slice 3 B29: lower inner quadrant slice 2 B30: lower inner quadrant slice 3. B31: lower inner quadrant with inferior margin slice 3. B31: upper central slice 4 B32: lower central slice 4 B33: upper outer quadrant with superior margin slice 5. B34: upper outer quadrant slice 5 B35: area immediately adjacent to mass slice 5 B36: area immediately adjacent to mass slice 5 B37: mass with deep margin and muscle slice 6 upper outer quadrant at deep margin B38: mass slice 6 B39: deep margin slice 6
+
+--- Page 2 ---
+TSS. B40: mass with deep margin slice 7 B41: mass with deep margin slice 7 upper outer quadrant mass with skin slice 7 B42: mass slice 7 upper outer quadrant. B43: skin, slice 8 upper outer quadrant. B44: mass with deep margin slice 8 upper outer quadrant B45: mass with deep margin slice 8 upper outer quadrant B46: mass with deep margin slice 9 upper outer quadrant B47: lower outer quadrant with inferior margin slice 7 B48: inferior margin slice 8 B49: area immediately adjacent to mass upper outer quadrant slice 10  B50: deep margin upper outer quadrant slice 10. DIAGNOSIS: A. LYMPH NODES, ADDITIONAL, LEFT AXILLARY, DISSECTION: - TEN LYMPH NODES, NEGATIVE FOR METASTASES (0/10). B. BREAST, LEFT, MASTECTOMY AND AXILLARY CONTENTS LEVELS 1 AND 2 DISSECTION: - INVASIVE, DUCTAL CARCINOMA, SBR GRADE 3 WITH SQUAMOUS FEATURES AND NECROSIS, MEASURING 9-CM - SURGICAL RESECTION MARGINS NEGATIVE FOR TUMOR - LOBULAR CARCINOMA IN SITU - METASTATIC CARCINOMA TO FIVE OF THIRTY FOUR LYMPH NODES (5/34), WITH EXTRANODAL EXTENSION, LARGEST MEASURING 1.5-CM - SEE SYNOPTIC REPORTS. SYNOPTIC REPORT - BREAST Specimen Type: Mastectomy Needle Localization: No Laterality:Left Invasive Tumor: Present Multifocality: No WHO CLASSIFICATION Invasive ductal carcinoma, NOs 8500/3 Tumor size: 9cm Tumor Site:  Upper outer quadrant. Central Margins:  Negative Tubular Score: 3 3 Nuclear Grade: Mitotic Score: 3 Modified Scarff Bloom Richardson Grade:. 3 Necrosis: Present Vascular/Lymphatic Invasion: None identified Lobular neoplasia: LCIS Lymph nodes: Axillary dissection Lymph node status: Positive 5 / 44 Extranodal extension DCIS not present ER/PR/HER2 Results ER: Negative PR: Negative HER2: Negative Pathological staging (pTN): pT 3 N 2a SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimen:  Surgical Excision
+
+--- Page 3 ---
+TSE Block Number: 844 ER: Negative Allred Score:  0 = Proportion Score 0 + Intensity Score 0 PR: Negative Allred Score:  0 = Proportion Score 0 + Intensity Score 0 COMMENT: The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the.. proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring. range from O to 8. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score. of less than or equal to 2. METHODOLOGY:  Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours.  Immunohistochemistry was performed usina the mouse anti-human ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) provided by following the manufacturer s instructions. This assay was not modified. Interpretation of the ER/PR immunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal. review of staining performance. SYNOPTIC REPORT - BREAST HER-2 RESULTS Specimen: Surgical Excision Block Number: B44 Interpretation:  NEGATIVE Intensity: 1+ % Tumor Staining: 5% Fish Ordered:  No  METHODOLOGY:  Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Her2 analvsis was performed using the FDA approved Dako HercepTest (TM) test kit :.  using rabbit anti-human HER2. This assay was not modified. External kit-slides.  provided by the manufacturer (cell lines with high, low and negative HER2 protein expression) and in-. house known HER2 amplified control tissue were evaluated along with the test tissue. Adequate, well preserved, clear-cut invasive carcinoma was identified for HER2 evaluation. Interpretation of the HER2 immunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal review of staining performance. This assay has been validated according to the 2007 joint recommendations and guidelines from. ASCO and CAP and from the NCCN HER2 testing in Breast Cancer Task Force. The Pathology Department takes full responsibility for this test's performance. CLINICAL HISTORY:  year old with left breast ca PRE-OPERATIVE DIAGNOSIS: Left breast ca Gross Dictation: Pathologist, ' Microscopic/Diagnostic Dictation: Pathologist, Microscopic/Diagnostic Dictation: Pathologist, 1 Final Review..., Pathologist, Final Review: Pathologist, Final Review: Pathologist, Final: Pathologist,
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diff --git a/output/text/a7944a23-de7c-474c-87e1-210e4b751d28.txt b/output/text/a7944a23-de7c-474c-87e1-210e4b751d28.txt
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index 0000000000000000000000000000000000000000..e96578adcfcc863f9e605acf0e933c347f17c9a9
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+Diagnosis: Right-sided hemicolectomy preparation with a cecal carcinoma, 5 cm in size at its maximum diameter, characterized histologically as a poorly differentiated colorectal adenocarcinoma. Invasive tumor spread as far as the level of the subserosa and adjoining fatty tissue.. Oral and aboral resection margin and also greater omentum tumor-free.. Appendix with evidently postinflammatory fibrosis of the wall.. Two of 16 mesocolic and mesenteric lymph nodes with metastases of the cecal carcinoma confined to the lymph nodes. Other lymph nodes with uncharacteristic reactive lesions. Tumor stage thus pT3 pN1 (2/16) L0, V0; G3
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diff --git a/output/text/a7a3d764-59a2-4194-924a-adb340951642.txt b/output/text/a7a3d764-59a2-4194-924a-adb340951642.txt
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index 0000000000000000000000000000000000000000..00e03279a287755f05a2d9194dd8abf79e49acb3
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+QUID:3423E8AE-CE73-4212-BB72-2AF92FD0BC2D TCGA-AN-A0XQ-01A-PR Redacted TSS Patient ID: Case #: DOB: Sex: Female Ethnicity (Race): Cancer Sample Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma Date of Procurement Anatomic Site: Breast Tumor location: Primary Tissue Specification: Tumor Specinen Matrix: Tissue Specimen Format: OCT Container: block Type of Procurement: surgery Grade: 2 T Stage: 2 N Stage: 1 M Stage: 0 Treatment: none Treatment Details: n/a Normal Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw Matrix: Blood Specimen Format: frozen Container tube Date of Procurement: 1cs-0-3 infiItretng duct, N0s 85oo/3 carciioma, l C 50.9 Sife: brust, Noj 0/21 HIPAA +0/$+/+?
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diff --git a/output/text/a7a92514-eb92-4db5-9972-9cfa86d8e2c4.txt b/output/text/a7a92514-eb92-4db5-9972-9cfa86d8e2c4.txt
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index 0000000000000000000000000000000000000000..3ee2199a7f26465bf845c87fe41d54ae73385c58
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+
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+ID03 UUID:39C2720B-D889-4D48-81EF-6DBC0D8A512C Redas epLtaIivaL mrcL 87s/3 Sute:Chweol C69.3 hI x/4|4 Enucleation of the right eye Macroscopy The eyeball measures 28 by 25 mm and the optic nerve 11 mm. Samples have been made for cryo preservation .The specimen has been then included entirely. Microscopy The eyeball is occupied by a tumor proliferation morphologic features of which are those of a choroidal melanoma containing mostly fusiform cells (90%) and rarely epithelioid cells (10%). The lesion is loaded with melanin pigment. The mitotic index is low with 5 mitosis out of 10 high 400 magnification fields. The lesion infiltrates the internal third of the sclera, there is no extrascleral extension. The tumor proliferation infiltrates the intraocular emergence of the optic nerve but the optic foramen, the post laminar section, the cut end and the meningeal sheaths are free of tumor. The iris, the ciliary body and the anterior chamber are free of tumor. Conclusion Choroidal melanoma with mostly fusiform cells Size of the lesion: 10mm Low mitotic activity. The tumor proliferation infiltrates the intraocular emergence of the optic nerve but the optic foramen, the post laminar section, the cut end and the meningeal sheaths are free of tumor. The iris, the ciliary body and the anterior chamber are free of tumor. 123
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diff --git a/output/text/a7b0b277-0139-4bef-9c39-cf58ec9a8ba3.txt b/output/text/a7b0b277-0139-4bef-9c39-cf58ec9a8ba3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7c0b815d309979010a93e439bb3a79ef1fafecab
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+UUID: 3A998600-37C3-4597-90D6-F92934879A2B TCgA-22-A935-01A-PR Redacted Pathology Report Gendert Servicer Received: Reported: Submitting Physiclare; Patnologistt Intraop Pathologssts. Ferrormzng Phyeicianx CLINICAL HISTORY'S AN YEAR-CLD CAUCASIAN MALE MTH RIGHT RENAL MAS IcD o-3 FREOPERATIVE DEAGNCSIS? NA4  826t[3 SFECIMEN TYPE(SI: A: 1ITH RIE, GROSS ONLY Site RYiolrey NDS H RIGHEKIDNEY FS T.64.9 FINAL.DIAGNCSIS FORTION CF IITHE RID, SECMENTAL RESECTICN: J/28/14 A. One piece or rib groes oniy). REGHT KTENEY, PARTIAL NEPHRECTCMY: Papillary rera: cell carcinoma, type I. Tumor sszer "10.s cm in maximn dimenason.. Renal capsular tnvsaionz Nos identiried. Margirs ce recection: Free or ssligrancy Fatnologio stage TZ NXMX M.D. .tne attending patnoicgiat, personaliy raviewed tne entire Ithiogy case and rendered the rinai Jiagroats.'siectronicaniy signed out ny DTHER RELATED CLNICAL DATA NA ENTRAOPEPATIVE DIAGNOSIS: ESB. RIGHT KICNEYS Esni.. Renal cell carcinoma, scstly necrotic. Xargin free. ot tumor.. Comment: Tnis Irozer' section diagrcale/resuit waa ccnmunicated to and acknowiedged by M.D.. nave perror.ed the intraoperative Consultat:on and issued the abtve diagncses. GROSS DESCRIPTION: A. Spacimen A is rocetved frasn lateled 'right nurber Il rib, Fortion.* Tne apacimen. consiat or 2rragments or rib measuring s.0 x 1.2 x 0.7 cm. Tne specimen Ta. grossty urresarkable.. Gross exsmination oniy..
+
+--- Page 2 ---
+B. Spedimen 3 is received rresh Iataled 'rignt kidney" rne apecimen consists or an. ovoid mass meaauring 20.0 x 15.0 x.12.0 cm and waign:ng 9a9.3 g... The.parenchyma1 sargin sf resection  is. srreguiar and ts Inxed in biack.. The perirephrte tat. margin cr resection is .Inxed an biue and Is.grosaly unremarkable. On sectioning: the. apecimen, an ovctd, wezl derined, tan-yellow, nemorrnagica, na parttally recrotie tumor' 1s present measuring 10.x i0,s x g.cm, The sumor i3 lacatecat. o7 cm .rrom Closest Inked. parenchymal. marg!n'of resection. The perinephric tat zargin ot. resecticn is nct grossly Involved.py tumor. Fhere are areas cr necrosis (sst or cte tumor!. Representative fresn ttesue' is not submitted to tne t:ssue procuresent. Laboratory.Aepresentattvesectlons.are submttted aa follows FSHI Tumor in relatton to clcsest inked margin or resection !parenchym3. Ferperdicular section perinephric rat margin ot. reeection.. 92-310: Tumor 3
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diff --git a/output/text/a7bf88ca-8069-4769-8bdb-694b15509137.txt b/output/text/a7bf88ca-8069-4769-8bdb-694b15509137.txt
new file mode 100644
index 0000000000000000000000000000000000000000..93732b050d6b19c4c91790a1790b57ae0ce20c40
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+--- Page 1 ---
+TSS IL ics-u-3 SPECIMENS: A. RIGHT BREAST CANCER B. ADDITIONAL LATERAL MARGIN Site: breast Nis c50.9 C. SENTINEL LYMPH NODE #1 H/8/4 D. SENTINEL LYMPH NODE #2 E. SENTINEL LYMPH NODE #3 SPECIMEN(S): A. RIGHT BREAST CANCER UUID:35F7D0D1-BA21-4135-8444-6B10EAF66F2S B. ADDITIONAL LATERAL MARGIN TCGA-E2-A1I3-01A-PR Redacted C. SENTINEL LYMPH NODE #1 D. SENTINEL LYMPH NODE #2 E. SENTINEL LYMPH NODE #3 INTRAOPERATIVE CONSULTATION DIAGNOSIS: Part A, Right breast, gross examination: Tumor is 1 cm from anterior/inferior/ medial margin TPC - TPE, Sentinel lymph nodes #1 - #3: Negative for carcinoma Diagnoses called to Dr. at. 1.(A) and . (C-E) by Dr. GROSS DESCRIPTION: A. RIGHT BREAST CANCER Received fresh labeled with the patient's identification and designated *right breast" is an oriented, 74-g, 7.6 x 6 x 4.3 cm needle localized lumpectomy specimen with two radiographs. The single suture designates anterior, double-lateral, triple-superior. Ink code: Anterior-yellow, posterior-black, medial- green, lateral-red, superior-blue, inferior-orange. The specimen is serially sectioned from medial to lateral into 6 slices, revealing a firm tan mass with granular cut surface, 2 x 1.2 x 1 cm, located 0.8 from the closest inferior margin. A clip is identified in slice 3. The remainder of the specimen shows areas of firm dense fibrous focally cystic parenchyma. A portion of the specimen is submitted for tissue procurement. Submitted representatively: A1: Medial margin A2-A3: Mass and anterior, slice 2 A4-A5: Mass and medial, slice 2 A6-A7: Mass, inferior / anterior, slice 3 A8-A9: Inferior/posterior, slice 3 A10: Superior, slice 3 A11: Posterior, slice 3 A12: Mass, inferior/ anterior, slice 4 A13: Inferior/anterior, slice 5 A14: Inferior/posterior, slice 5 A15-A16: Lateral margin B. ADDITIONAL LATERAL MARGIN  Received in formalin in a container labeled with the patient's identification and designated *additional lateral margin" is an oriented (suture at final margin) 8-g, 4.1 x 4 x 0.5 cm fragment of fibroadipose tissue. The final margin inked black. Sectioning shows nodule measuring 0.5-cm. Submitted entirely: B1-B3: Serial sections B4: Nodule B5: Serial sections C. SENTINEL LYMPH NODE #1 Received fresh labeled with the patient's identification and designated *Sentinel lymph node #1" is a fragment of fibroadipose tissue, 3 x 2.3 x 1.1 cm showing one possible 2-cm lymph node. Touch preparation is performed. The lymph node is entirely submitted in cassette C1. D. SENTINEL LYMPH NODE #2  Received fresh labeled with the patient's identification and designated "Sentinel lymph node #2" is a fragment of fibroadipose tissue, 3 x 1.5 x 1 cm, showing a possible 2.3-cm lymph node. Touch preparation is performed. The lymph node is entirely submitted, D1. E. SENTINEL LYMPH NODE #3 Received fresh labeled with the patient's identification and designated "Sentinel lymph node #3" is a fragment of fibroadipose tissue, 3.1 x 2.2 x 1.1 cm, showing a possible 1.5-cm lymph node. Touch preparation is performed. The lymph node is entirely submitted, E1. DIAGNOSIS: A. BREAST, RIGHT, WIDE LOCAL EXCISION:
+
+--- Page 2 ---
+TSS ID - INVASIVE LOBULAR CARCINOMA, SBR GRADE 2, MEASURING 1.5-CM - LOBULAR CARCINOMA IN SITU - SURGICAL RESECTION MARGINS NEGATIVE FOR INVASIVE TUMOR - LCIS PRESENT AT LATERAL AND MEDIAL SURGICAL RESECTION MARGINS AND WITHIN 1 MM FROM INFERIOR SURGICAL RESECTION MARGIN - BIOPSY SITE CHANGES WITH FIBROSIS - FIBROADENOMA - SEE SYNOPTIC REPORT AND SEE NOTE. B. BREAST, RIGHT, LATERAL MARGIN, EXCISION: - INVASIVE LOBULAR CARCINOMA, SBR GRADE 2, MEASURING 0.6-CM - LOBULAR CARCINOMA IN SITUE - LCIS PRESENT WITHIN 1 MM FROM FINAL LATERAL MARGIN - iNVASIVE TUMOR PRESENT 2.5 MM FROM FINAL LATERAL MARGIN - See note. C. LymPh NODE, SENTINEL #1, RiGht AXILLA, EXCiSiON: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1). D. LYMPH NODE, SENTINEL #2, RIGHT AXILLA, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1). E. LYMPH NODE, SENTiNEL #3, RIGHT AXILLA, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1). NOTE: The in situ and invasive tumors are negative for E-cadherin, compatible with lobular carcinoma phenotype. In part A., the main tumor mass is identified in slices #2 and 3. However, additiona!. scattered foci of invasive lobular carcinoma are identified in slices #4, 5, 6 and 7. Moreover, the. additional submitted lateral margin (part B.) shows invasive lobular carcinoma (0.6-cm). Therefore, this tumor is considered multifocal. Lobular carcinoma in situ is identified throughout the submitted sections. The closest surgical resection margin to invasive lobular carcinoma is the lateral (2.5 mm). LCIS is. identified at medial and within 1 mm from inferior and lateral surgical resection margins. SYNOPTIC REPORT - BREAST Specimen Type: Excision Needle Localization: Yes - For mass Laterality: Right Invasive Tumor: Present Multifocality: Yes WHO CLASSIFICATION Invasive lobular carcinoma 8520/3 Tumor size: 1.5cm Tumor Site:  Not specified Margins: Negative Distance from closest margin:  0.25cm lateral Tubular Score: 3 Nuclear Grade: 2 Mitotic Score: 2 Modified Scarff Bloom Richardson Grade: Necrosis: Absent  None identified Vascular/Lymphatic Invasion: Lobular neoplasia: LCIS Lymph nodes:  Sentinel lymph node only Lymph node status:  Negative 0/3 DCIS not present
+
+--- Page 3 ---
+TSS ID ER/PR/HER2 Results ER: Positive PR: Positive HER2: Negative by FISH Performed on Case:  s09-118 Pathological staging (pTN):  pT 1c N 0 CLINICAL HISTORY:  None given PRE-OPERATIVE DIAGNOSIS: Right breast cancer Gross Dictation: ., Pathologist, Microscopic/Diagnostic Dictation: .. Pathologist, Final Review: ., Pathologist Final Review: ., Pathologist, Final: ., Pathologist,
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diff --git a/output/text/a803bf5d-65cd-4988-9209-6500a9852ec4.txt b/output/text/a803bf5d-65cd-4988-9209-6500a9852ec4.txt
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index 0000000000000000000000000000000000000000..c411af13e53bb64891cda5e35d1bb71b76a4643a
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+--- Page 1 ---
+SIACunCIc INQHIRY UUID:F6CEA42D-A107-4942-B6FE-1C529D124337 TCGA-OR-A5K2-01A-PR Redacted PAGE #: SEX:F PAT TYPE: ADM DATE: OPER DATE: PROCEDURE: APMI ADDENDUM REPORT FOLLOWING DISCUSSION WITH THE SURGEON: After discussing the margin stasis with the surgeon it is clear that the. previously reported positive surgical margin is in fact not a true margin.. Following removal of the tumor, a small capsular defect was noted at the. superior aspect and this was felt to be iatrogenically induced. No tunor spillage resulted from this and the tumor was clearly covered by a glistening unremarkable capsule following removal. Therefore, please see revised template and diagnosis below. ADRENOCORTICAL CARCINOMA v3 Tumor size: 14.5 x 11 x 7.9 cm. Tunor Weight: 560 grams. Capsular Invasion: Present. Vascular Invasion: Present. Surgical Margins:  Negative. Necrosis: Present (20%). S Mitotic Rate:  51/50 high power field. Grade: High-grade. ICD-O-3 Lymph nodes status: 0/1. Extra-adrenal Extension: Present. Stage: pT4 NX MX PROCEDURE: APDX 2. Right adrenal gland and vena cava, resection: High-grade adrenocortical. carciroma (560 gram, 14.5 cm), completely excised. Extensive vascular invasion 1130/13 including venus invasion within periadrenal soft tissues. Please see template for details. 8370/3 1 and 3-5. Please see previous report for diagnosis which remains unchanged.
+
+--- Page 2 ---
+PREVIOUS DIAGNOSIS INQUIRY PAGE #: SEX? F SIRTHDATE: PAI IIPE: ADMDATE: OPER DATE: +he signing staff pathologist, have personally examinea ana interprerea tne stides from this case.. PROCEDURE: SPHS Testosterone producing adrenal cortical carcinoma and vena cava thrombosis extending to chest. Also has history of multinodular goiter for four years. 14. cm right adrenal mass, 20 Ib weight loss over two months, lung nodule, liver. mnass, IVc thrombus. PROCEDURE: SPGD 1. "Peritoneal implant#. A 0.2 cm soft tissue fragment. 1A. Frozen section control. 2. "Right adrenal tumor and vena cava thrombus". Received in formalin in a large container is a 560 gram, 14.5 cm superior to inferior x 11.0 cm medial to lateral x 7.9 cm anterior to posterior resection specimen which was received fresh for procurement. Specimen is oriented as follows: Two long interior, two short superior, one long lateral, two medial vena cava thrombus,. two extra long anterior. The external surface ot the resection specimen is smooth and the resection specimen is composed almost entirely ot tumor. Cut surfaces are pink-tan with foci of bright yellow streaking through the tumor. A smalt amount of residual identifiable adrenal gland is present, however, there are no definitive areas of gross necrosis. There are possible lymph nodes in the periadrenal as well as near the vascular insertions.. 2A-8. Lateral margin. 2C-D. Anterior margin. 2e. Tunor near stitch for vena cava thrombus 2F-G. Medial margin. 2H-I. Inferior margin, serially sectioned. ?J-K. Radial sections to superior margin. 2L. Representative sections of posterior margin.. 2M-N. Periadrenal lymph nodes. 20-R. Central portion of mass. 3. "Vena cava margin'. Received in formalin in a small container is a 1.2 x 0.6 x 0.2 cm portion of soft tissue. Entirely submitted in one cassette.
+
+--- Page 3 ---
+PREVIOUS DIAGNOSIS INQUIRY PAGE #: 5 SEX F PAT TYPE: ADMDATE: BIRTHDATE: OPER DATE: 4. "periadrenal tissue" Received in formalin in a small container is a i.I / 0.7 x 0.2 cm portion of soft tissue. Entirely submitted in one cassette. 5. "Gallbladder" Received in formalin in a small container is a 5.4 x 2.4 x 1.3 cm gallbladder. Serosal surface is grossly unremarkable. Wall thickness is unremarkable at 0.1 cm. Luminal contents consists of green bile. No stones identified. Mucosal surfaces grossly unremarkable. 5A. Cystic duct in artery and representative section of cystic wall. FROZEN SECTION REPORT 1. Papillary mesothelial proliferation. Negative for carcinoma. have reviewed and interpreted the frozen section 'equested. Permanent sections confirm frozen section report. PROCEDURE: SPMI ADRENOCORTICAL CARCINOMA V3 Tumor Size: 14.5 x 11 x 7.9 cm Tumor Weight: 560 gm Capsular Invasion: Present Vascular Invasion: Present Surgical Margins: Positive (superior) Necrosis: Present (20%) Mitatic Rate: 51/50 high power field Grade: High grade Lymph nodes status: 0/1 Extra-adrenal Extension: Present Stage: pT4 NX MX
+
+--- Page 4 ---
+PREVIOUS DIAGNOSIS INQUIRY PAGE#: SEX:F BIRTHDATE: Iype: ADM DATE: OPER OATE: PROCEDURE: SPDXE 1. Peritoneum, biopsy: Papillary mesothelial hyperplasia. Negative for. carcinoma. 2. Right adrenal gland and vena cava, resection: High grade adrenocortical. carcinoma (560 gm, 14.5 cm), extending to the superior margin. Extensive. vascular invasion. Please see template for details. 3. Vena cava, margin, excision: Detached fragment of adrenocortical carcinoma.. No carcinoma in vein wall.. 4. Periadrenal soft tissue, resection: One lymph node negative for carcinoma. 5. Gallbladder, resection: No significant abnormality.. the signing statt patnologist, have personally. examinea ana interpretea tne slides from this case.. ******* ** END OF PREVIOUS DIAGNOSIS INQUIRY ** 122
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diff --git a/output/text/a810755a-c541-4f52-b20e-b08de3e837f5.txt b/output/text/a810755a-c541-4f52-b20e-b08de3e837f5.txt
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index 0000000000000000000000000000000000000000..c537b8f96e278e81a05cb6a587b485d4b6138351
--- /dev/null
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+--- Page 1 ---
+Clinical Diagnosis & History: 1/0 female with left breast IDC Specimens Submitted: 1: sp: Level three left axillary lymph nodes 2: SP: Level two left axillary lvumh nodes 3 SP: Lateral left breast skin 4: SP:  Right upper abdominal skin tag 5: Sp: Left breast and level 1 axillary sympn nodes  UUID: 6C202D3E-5670-4B63-82A2-9EE7AC3850890 TCGA-AO-A03B-01A-PR Redacted DIAGNOSIS: 1) SOFT TISSUE, LEVEL III LEFT AXILLA; EXCISION: - BENIGN FIBROADIPOSE TISSUE. - NO LYMPH NODE IDENTIFIED. 2) LYMPH NODES, LEVEL II LEFT AXILLA; EXCISION: - THREE BENIGN LYMPH NODES (O/3). 3) SOFT TISSUE, LATERAL LEFT BREAST; EXCISION: - ONE BENIGN LYMPH NODE (0/1). - BENIGN FIBROADIPOSE TISSUE. 4) SKIN, RIGHT UPPER ABDOMINAL TAG; EXCISION: - IRRITATED SEBORRHEIC KERATOSIS. 5) BREAST AND LEVEL I AXILLARY LYMPH NODES, LEFT; MASTECTOMY: INVASIVE DUCTAL CARCINOMA, HISTOLOGIC GRADE III/III (SLIGHT OR NO TUBULE FORMATION), NUCLEAR GRADE II/III (MODERATE VARIATION IN SIZE AND SHAPE), WITH AREAS OF LOBULAR GROWTH, MEASURING 11.O CM IN LARGEST DIMENSION GROSSLY. - DUCTAL CARCINOMA IN SITU (DCIS) IS ALSO IDENTIFIED, SOLID TYPE, WITH MODERATE HIGH NUCLEAR GRADE AND EXTENSIVE NECROSIS. - LOBULAR INVOLVEMENT BY DCIS IS PRESENT. - THE DCIS CONSTITUTES <- 25% OF THE TOTAL TUMOR MASS, AND IS PRESENT ADMIXED WITH AND AWAY FROM THE INVASIVE COMPONENT. - THE INVASIVE CARCINOMA IS LOCATED IN THE UPPER OUTER QUADRANT, UPPER INNER QUADRANT AND LOWER OUTER QUADRANT. - THE DCIS IS LOCATED IN THE UPPER OUTER QUADRANT, UPPER INNER QUADRANT AND LOWER OUTER QUADRANT. ** Continued on next page ** 1cs-0-3 cai oro,ii fi1tnatHny duct, nes I5ocf3 riteria iagn JSOUA
+
+--- Page 2 ---
+- NO INVOLVEMENT OF THE NIPPLE BY EITHER IN SITU OR INVASIVE CARCINOMA IS IDENTIFIED.S -. CALCIFICATIONS ARE PRESENT IN THE IN SITU AND INVASIVE CARCINOMA, AND IN BENIGN BREAST PARENCHYMA. EXTENSIVE VASCULAR INVASION IS PRESENT. - NO INVOLVEMENT OF THE SURGICAL MARGINS BY BITHER INVASIVE OR IN SITU CARCINOMA IS IDENTIFIED. - NO SKIN INVOLVEMENT BY CARCINOMA IS IDENTIFIED.S THE ATTACHED SKELETAL MUSCLE IS UNINVOLVED BY CARCINOMA.S - THE NON-NEOPLASTIC BREAST TISSUE SHOWS BIOPSY SITE CHANGES ANDS PROLIFERATIVE FIBROCYSTIC CHANGES. - THE LYMPH NODE STATUS IS AS FOLLOWS (EXPRESSED AS THE NUMBER OF POSITIVE LYMPH NODES IN RELATION TO THE TOTAL NUMBER OF LYMPH NODES BXAMINED) : LEVEL I: 1/10. - THERE IS EXTRANODAL EXTENSION OF CARCINOMA, >2 MM.  IMMUNOHISTOCHEMICAL STAINS WERE PERFORMED ON FORMALIN-FIXED TISSUE WITH THE FOLLOWING RESULTS FOR INVASIVE CARCINOMA (BLOCK 5T5) : ESTROGEN RECEPTOR (6F11, 90% NUCLEAR STAINING WITH STRONG INTENSITYS PROGESTERONE RECEPTOR (1E2; 60% NUCLEAR STAINING WITH MODERATE INTENSITYS HER2 (HERCEPTEST; DAKO): 2 NEGATIVE (STAINING) INTENSITY OF 0) CONTROLS ARE SATISFACTORY. COMMENT : HERCEPTESTTM (DAKO) IS AN FDA-APPROVED METHOD FOR ASSESSMENT OF HER2 PROTEIN OVEREXPRESSION IN BREAST CANCER TISSUE ROUTINELY PROCESSED FOR HISTOLOGICAL EVALUATION. THE HER2 TEST RESULTS ARE REPORTED IN ACCORDANCE WITH THE ASCO/CAP GUIDELINE RECOMMENDATIONS FOR HER2 TESTING IN BREAST CANCER (J CLIN ONCOL 2007; 25(1):1-28). I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL). AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. * Report Blectr ically Signed Out *** Special studies: Result Special Stain Comment ER-C PR-C HER2-C IMM RECUT NEG CONT NEG-HER2 Gross Description: ** Continued on next page **
+
+--- Page 3 ---
+MD D. 1.)  The specimen is received in formalin, labeled "level 3 left axillary lymph nodes" and consists of two irregularly shaped fragments of yellow lobulated adipose tissue measuring 1.0 x 1.0 x 0.2 cm in aggregate. No lymph nodes are identified grossly. The specimen is entirely submitted.. Summary of sections: U-undesignated 2.  The specimen is received in formalin, labeled "level 2 left axillary lymph nodes" and consists of one irregularly shaped fragment of yellow lobulated adipose tissue measuring 3.5 x 2.5 x 0.3 cm. Three possible lymph nodes are identified, ranging from 0.3 cm to 0.5 cm in greatest dimension. The lymph nodes are entirely submitted.. Summary of sections: U -- undesignated 4.D. 3.) The specimen is received in formalin, labeled -lateral left breast skin" and consists of one irregularly shaped fragment of yellow to tan fibroadipose tissue measuring 10.3 x 2.9 x 1.4 cm. No skin is identified grossly.  Serial sectioning reveals a grossly unremarkable fibroadipose tissue with a single possible lymph node measuring 0.4 cm in greatest dimension. Representative sections are submitted.. 3 Summary of sections: U-undesignated .D. 4.) The specimen is received in formalin, labeled "right upper abdominal skin tag" and consists of one polypoid shaped fragment of brown skin measuring 0.3 x 0.2 x 0.2 cm. The specimen is entirely submitted. Summary of sections: U-undesignated .D 5.) The specimen is received fresh, labeled "left breast and level 1 axillary lymph nodes, stitch marks level 1 axillary lymph nodes" and consists of a breast with attached axillary tail. The breast measures 22.2 x 16.0 x 3.5 cm with overlying skin ellipse measuring 16.6 x 7.9 cm. Situated eccentrically on the skin surface is an everted nipple measuring 1.2 x 1.1 x 0.3 cm and areola measuring 4.9 x 4.1 cm. The skin shows no scars. A suture demarcates the axillary tail which measures 9.8 x 5.5 x 1.5 cm. The posterior surface of the breast is inked black and the specimen is serially sectioned to reveal an irregularly shaped white-tan firm mass. ** Continued on next page **
+
+--- Page 4 ---
+involving upper outer, lower outer and upper inner quadrants, located 0.6 cm away from the deep resection margin. The remaining breast tissue shows predominantly yellow lobulated adipose tissue admixed with scant white-tan fibrous soft tissue with no other grossly identifiable lesions. The axillary tissue is dissected to reveal multiple lymph nodes ranging in size from 0.5 cm to 2.5 cm.  The specimen is submitted for lymph node dissection.. Representative sections of the. mastectomy specimen and all identified axillary lymph nodes are . submitted Tissue submitted for TPS. Summary of sections: N - nipple NB - nipple base S - skin D deep margin tumor UIQ upper inner quadrant LIQ - lower inner quadrant. UOQ upper outer quadrant LOQ - lower outer quadrant LNS lymph nodesd 4 Summary of Sections: Part 1: Sp: Level three left axillary lymph nodes Block Sect. Site PCs 1 U 1 Part 2: SP: Level two left axillary lymph nodes. Block Sect. Site PCs 1 u 1 Part 3: SP: Lateral left breast skin (sr) Block Sect. Site PCs 1 U 1 Part 4: SP: Right upper Block Sect. Site PCs U 1 Part 5: SP: Left breast and level 1 axillary lymph nodes Block Sect. Site PCs H D 1 2 LIQ 2 6 LN 11 2 LOQ 2 ** Continued on next page **.
+
+--- Page 5 ---
+UOQ S ** End of Report
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diff --git a/output/text/a8184429-2992-4d60-afcf-1daa789d49da.txt b/output/text/a8184429-2992-4d60-afcf-1daa789d49da.txt
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+SURGICAL PATHOLOGY REPORT * Addendum * Patient: Accession #: MRN: Service: Account Date of Procedure: DOB: Date of Receipt: Physiciai Date of Report: Cc: Patient Address: Date of Procurement: Clinical Diagnosis & History: Left tonsillar mass/ carcinoma status post left radical tonsillectomy. Specimens Submitted: TCD-o-3 1: Deep margin left constricture muscle (fs) 2: Soft palate margin (fs) 3: Lateral pharyngeal margin (fs) 4: Left tongue base margin (fs) Mox-horaTr&jncy 807q/3 5: Posterior tonsillar pillar margin (fs) 6: Left radical tonsillectomy Coq.9 7: Deep muscle additional resection DIAGNOSIS: 1. Deep margin left constricture muscle (fs): - Benign skeletal muscle. Separate detached fragment of atypical squamous epithelium. Note: The fragment of atypical squamous epithelium was not present on the original frozen section slide. Soft palate margin (fs): ? UUID:F170BB49-FA71-4247-AFA7-F841A3488171 - Benign squamous mucosa TCGA-RS-A6TP-01A-PR Redacted Lateral pharyngeal margin (fs): 3  Benign squamous mucosa Left tongue base margin (fs): - Benign tonsilar tissue 5. Posterior tonsillar pillar margin (fs): - Benign squamous mucosa Left radical tonsillectomy: 6 Tumor Type: Invasive squamous cell carcinoma non-keratinizing Histologic Grade: Poorly differentiated ** Continued on next page
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT Tumor Size: Greatest diameter is 2.5 cm Maximal thickness 1.7cm Tumor Location: Left tonsil Midline Extension:. N/A Tumor Invasion: Skeletal muscle Tumor Necrosis: Extensive Vascular Invasion:  Not identified Perineural Invasion:. No definite peri-neural invasion seen.. Pattern of Invasion:. Invasive islands Tumor Multicentricity: Not identifed In situ carcinoma: Identified Non-Neoplastic Mucosa: Exhibits chronic inflammation Surgical Margins: Free of in situ carcinoma Invasive carcinoma is close (less than 1 mm) from deep margin in this part. 7. Deep muscle additional resection: Benign skeletal muscle and squamous mucosa.. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL BXAMINATION OFS THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVEDS THIS REPORT. *** Report Electronically Signed Out. Gross Description: 1) The specimen was received fresh for frozen section and labelled "Deep. margin left constricture muscle" and comprised a 0.8 x 0.6 x 0.2 cm piece of muscular tissue. Entirely submitted for frozen section.. Summary of sections FSC frozen section control 2) The specimen was received fresh for frozen section and labelled "Soft. palate margin" and comprised a 0.8 x 0.5 x 0.2 cm piece of tissue. Entirely * Continued on next page *
+
+--- Page 3 ---
+SURGICAL PATHOLOGY REPORT Page 3 of 5 submitted for frozen section Summary of sections FSC frozen section control 3) The specimen was received fresh for frozen section and labelled "Lateral. pharyngeal margin" and comprised a 0.4 x 0.3 x 0.2 cm piece of tissue. Entirely submitted for frozen section. Summary of sections FSC frozen section control 4) The specimen was received fresh for frozen section and labelled "Left tongue base margin" and comprised a 0.7 x 0.4 x 0.2 cm piece of muscular tissue. Entirely submitted for frozen section. Summary of sections Fsc frozen section control 5) The specimen was received fresh for frozen section and labelled. "posterior tonsillar pillar margin" and comprised a 0.8 x 0.2 x 0.2 cm piece. of muscular tissue. Entirely submitted for frozen section. Summary of sections Fsc frozen section control 6) The specimen is received fresh labeled "Left radical tonsillectomy,. suture marks inferior" and consists of a 4.2 x 2.6 x 1.3 cm tan-pink tonsil. with a suture indicating the inferior margin. The suture is arbitrarily designated as 12:00. The surface of the tonsil exhibits a 2.5 x 1.8 x i.8 cm friable tan-white polypoid fungating tumor which is 2.1 cm from 12:00, 1.0 cm from 3:00, 2.0 cm from 6:00, and 1.6 cm from 9:00 from the mucosal. margin.  The deep margin in inked green from 12:00-6:00, and blue from. 6:00-12:oo. Serially sectioning displaya the tumor to abut the deep margin, with a maximal depth of 1.7 cm. The specimen is entirely submitted. Summary of sections: 12T- 12:00 tip, perpendicular S- sequential sections from 12:00 to 6:00, contiguous sections blocks :7-8, 9-10 6T- 6:00 tip, perpendicular FT- friable tumor 7) The specimen is received fresh labeled "Deep muscle additional resection". and consiats of a 1.7 x 0.9 x 0.5 cm irregular tan-red rubbery tissue which ** Continued on next page
+
+--- Page 4 ---
+SURGICAL AULUGY REPORT Page of5 is bisected and entirely submitted Summary of sections: U- undesignated Summary of Sections:. Part 1: Block Sect.  Site PCs 1 Fsc Part 2: Soft palate margin. Block Sect. Site PCs 1 Fsc 1 Part 3: Lateral pharyngeal margin Block Sect. Site PCs 1 Fsc 1 Part 4: Left tongue base margin Block Sect. Site. PCs 1 Fsc 1 Part 5: Posterior tonsillar pillar margin Block Sect. Site. PCs Fsc 1 Part 6: Left radical tonsillectomy Sect. site Block PCa 1 12T 3 6T 19 6 1 10 Part 7: Deep muscle additional resection Block Sect. Site. PCs U 2 Procedures/Addenda: Addendum ** Continued on next page
+
+--- Page 5 ---
+SURGICAL PATHOLOGY REPORT Page 5 of 5 Date Ordered: Status: Signed Out Date Complete: Date Reported: Addendum Diagnosis 6. Left radical tonsillectomy: - The tumor cella are strongly and diffusely poaitive for pl6. The tumor is positive for high risk Hpv by in-situ hybridization.. *** Report Electronically Signed Out ** Signed out by Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 1. FROZEN SECTION DIAGNOSIS: Benign PERMANENT DIAGNOSIS: See final 2. FROZEN SECTION DIAGNOSIS: Benign  PERMANENT DIAGNOSIS: same 3. FROZEN SECTION DIAGNOSIS: Benign PERMANENT DIAGNOSIS: SAme 4. FROZEN SECTION DIAGNOSIS: Benign PERMANENT DIAGNOSIS: Same 5. FROZEN SECTION DIAGNOSIS: Benign PERMANENT DIAGNOSIS: same * End of Report ual/Synchronous se is (circie):
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diff --git a/output/text/a81cc82a-8d87-4cdc-be8f-9b945399a7b8.txt b/output/text/a81cc82a-8d87-4cdc-be8f-9b945399a7b8.txt
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index 0000000000000000000000000000000000000000..4f277f27a0adc99776e9553ed7ab87a900e37633
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+UUID:706EC715-C6CD-49A9-8993-D6E5820AED95 TCGA-PK-A5H8-01A-PR Redacted LABORATORY MEDICINE PROGRAM teD-o-3 arc nomc, adrenal eortical 8370 3 IdrenalC land, Cor tex C74.D JtO 1/8/13 Surgical Pathology Consultation Report. Patient Name: Accession #: Service: MRN: Collected: DOB: Visit #: Received: Gender.  Location: Reported: HCN: Facility: Ordering MD: Copy To: Specimen(s) Received 1. Adrenal: Right Adrenal Gland 2. superior medial margin of tumour Diagnosis 1. Adrenocortical carcinoma with atrophy of normal adrenal cortex: Adrenal (right) adrenalectomy specimen 2. Cortical atrophy, negative for malignancy: Adrenal No pathological diagnosis: Paraganglia and soft tissue. (superior medial margin) resection. Electronically verified by: Clinical Historye None given. Gross Description. 1. The specimen container labeled with the patient's name and as "adrenal right adrenal gland" contains an encapsulated mass that measures 19.5 x 13.5 x 6.5 cm and weighs 870 grams. The specimen has an intact capsule and has a red to gray colour. On section, the cut surface is solid, tan-brown and focally necrotic. Representative tumor tissue is stored frozen. Representative sections are submitted as follows:. 1A-Krepresentative sections 2. The specimen container labeled with the patient's name and as "superior medial margin of tumour" contains a single piece of unoriented brown soft tissue that measures 3.2 x 2.0 x 1.4 cm. The margins are painted with silver nitrate 2A,B serially sectioned and submitted in toto. Microscopic Description 1. Adrenal DOMINANT LESION: Adrenocortical tumour SIZE: 19.5 cm maximum dimension WEIGHT: 870 grams ARCHITECTURE: cellular lesion with predominantly solid nesting architecture. Page 1 of 2
+
+--- Page 2 ---
+Surgical Pathology Consultation Report CYTOLoGy: predominant compact cell morphology with focal clear cell change; nuclear atypia and pleomorphism with prominent nucleoli and frequent atypical mitotic figures DEGENERATION: geographic and punctate necrosis ENCAPSULATION: thick capsule CAPSULAR INVASION: not identified EXTRAADRENAL EXTENSION: not identified RESECTION MARGINS: not involved LYMPHOVASCULAR iNVOLVEMENT: vascular invasion with thrombus identified in multiple areas OTHER ADRENAL PATHOLOGY: atrophy of the normal cortex involving primarily the zona reticularis LYMPH NODES: none identified Page 2 of 2
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diff --git a/output/text/a833f487-c546-4138-8dcd-2a88481e3b27.txt b/output/text/a833f487-c546-4138-8dcd-2a88481e3b27.txt
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index 0000000000000000000000000000000000000000..8583dc0335ac9ad032e5c0fd07b75f03de4d66d9
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+The material in Block A is an invasive carcinoma, and adenocarcinoma of the colon, characterized here as a serrated adenocarcinoma of grade G2 with infiltration of the muscularis pT2 with vascular infiltration L1, V1. In the region of the mucosa, it also shows free mucosal margins with a regular mucosa, submucosa and muscularis and regular fatty connective tissue in the direction of the central ligature. The material in Block D is additonally a polyp characterized as a serrated adenoma without dysplasia (not a high-grade neoplasia), free lymph nodes with a marked resorptive lymphadenitis, in relation to the macroscopically named adjacent node likewise a regular lymph node and in relation to Block H the formation of a diverticulum, here typically in the sense of a pseudodiverticulum with an eversion between the gaps in the muscle wall. In relation to the the central resection margin: mature fatty connective tissue with dilated vessels and, in relation to the lymph nodes, a chronic resorptive lymphadenitis. Tumor classification: ICDO-DA-M G 2 pT2 L1, V1 pN0 (0 of 18 + 1) with complete local excision
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diff --git a/output/text/a85fed87-e1ae-4877-acb9-f2566d3b1ea4.txt b/output/text/a85fed87-e1ae-4877-acb9-f2566d3b1ea4.txt
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index 0000000000000000000000000000000000000000..7fe084d48a8626ce3c130ae1513f2a96414a71a7
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+TeD O-3 JUID:9 799100 Redacted 377213 Sute MuoI tocF Ck9.4 HO2/16/14 Enucleation of the right eye. Macroscopy: The eyeball measures 28x20 mm and the posterior optic nerve segment 7 mm. At the section, it presents a black tumor measuring 13 mm main line. The piece has been fixed and included entirely. Su pamh dusereparry frn  Microscopy lpiHuioid au! Spidl eill rats.. The specimens observed present a cell proliferation with the histological features of a. melanoma. This tumor is mainly composed of fusiform cells (97%) which present moderate nuclear atypias and a large cytoplasm frequently loaded with melanin. The mitotic index is low (three mitoses per 10 high power field). The tumor size is 13 mm main line. The lesion invades the ciliary body . The sclera is free. The optic nerve on its entire course as well as its cut end and the meningeal sheath are free of tumor. Conclusion: Uveal melanoma composed of fusiform cells (97%) Epithelioid cells: <3% Tumor size: 13 mm.. Tumor extension of the ciliary body The sclera is free. No extrascleral extension. Optic nerve in its entire course, cut end of the optic nerve and meningeal sheaths free of tumor..
+
+--- Page 2 ---
+V4.00 TCGA Pathologic Diagnosis Discrepancy Form Instructions: The TCGA Pathologic Diagnosis Discrepancy Form should be completed when the pathologic diagnosis documented on the initial pathology report for a case submitted for TcGA is inconsistent with the diagnosis provided on the Case Quality Control Form completed for the submitted case.. Tissue Source Site (TSS): TSS Identifier: . TSs Unique Patient Identifier: . Completed By (Interviewer Name on OpenClinica): . Completed Date: _ Diagnosis Information Data Element Entry Alternatives Working Instructions <3% epithelioid cells Provide the diagnosis/histologic subtype(s) documented on  Pathologic Diagnosis the initial pathology report for this case. If the histology for.  Provided on Initial this case is mixed, provide all listed subtypes. 97% spindle cells  Pathology Report Histologic features of 61-90% spindle cells Provlde the histologic features selected on the TCGA Case the sample provided Quality Control Form completed for this case. for TCGA, as reflected 1-30% epithelioid cells  on the CQCF. Discrepancy between Pathology Report and Case Quality Control Form  Provide the reason for  Provide a reason describing why the diagnosis on the initial. the discrepancy The section of the frozen sample used for sending. pathology report for this case is not consistent with the.  between the pathology to TCGA corresponds to a section of the tumor diagnosis selected on the TCGA Case Quality Control Form. report.and the TCGA where the epithelioid part is predominant. Case Quality Control Form. The percentages mentioned on the initial  Pathology Report correspond to an average on the  whole embedded sections used for establish the  Pathology Report.  Name of Tss Reviewing Provide the name of the pathologist who reviewed this case Pathologist or for TCGA. Biorepository Director I acknowledge that the above informatlon provided by my institution Is true and correct and has been quality controlled. TSS Reviewing Pathologist o/Biorepository Director Date I acknowiedge that the above information provided by my institution is true and correct and has been quality controlled. The Attending Pathologist or the Department Chairman has been informed or is aware of the above dlscrepancy in diagnoses. Principal Investigator Signature Date
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diff --git a/output/text/a899f7a8-343d-47be-ae82-9614a02dcd4c.txt b/output/text/a899f7a8-343d-47be-ae82-9614a02dcd4c.txt
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index 0000000000000000000000000000000000000000..925bdf607919d0fd2d80dfb8fe2698e1643451f9
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+FINAL DIAGNOSIS:  Part 1: Lymph node, Right sentinel #1, ExcisiOn -- One (1) Lymph noDe, negative for metastatic ADenocarcinoma (0/1). PArt 2: Lymph nODe, right Sentinel #2, EXcisiOn -  ONE (1).LYMPH NODE, POSITIVE FOR MICROMETASTASIS TWO (2) FOCI MEASURING LESS THAN 1.0 mm, AnD ONe (1) ALsO LEss THA 1.0 mm (1/1) (see comment). B. NO EXTRACAPSULAR SPREAD IS SEEN. Part 3: Lymph nOde, Right SentineL #3, EXcisiOn -- 1cs-0-3 ONE (1) LymPH NODE, NEGATIVE FOR METASTAT!C ADENOCARCINOMA (0/1). carcinoms, nifiltnstrug chuhd, nos 85os/3 Part 4: Lymph node, Right non-sentinel, ExcisiOn -- One (1) Lymph nODe, negative fOr metastatic Adenocarcinoma (0/1). Sit:brest Ns C50.9 3/1/u p Part 5: Breast, Right, segmental mastectomy - A.  infILtrating Ductai cArcinoma nOs *NOTTinghAm grade 1, ScOre Of 5/9 (tuBuleS = 2, nucLEI = 2, miTOsiS = 1). C. Tumor measures 2.0 cm on gross examination. D.  Ductal Carcinoma in-situ, cribriform type and with ComedO necrosis, nuclear grade 2. ADmIXeD wITh inVaSIve COmpOnent, COmprISiNg APprOXImateLy LeSs ThAn 5% Of The tOTAl TumOr VOLUmE. E.  SURGICAL MARGINS OF RESECTION ARE FREE OF INVASIVE TUMOR. F. CLOSEST POSTERIOR AnD SUPERiOR mARGInS OF RESECTION ARE AT 0.6 CM.E  mArgiNs Of resectiOn Are free Of Ductal CarcinOmA IN-SItU, CLOsest POsteriOr mArgIn C At 1.2 Cm. H. ANGIOLYMPHATIC INVASION IS IDENTIFIED. Estrogen receptor positive, progesterone receptor positive, her-2/neu negative (SCOre 0), per previous repORt SkiN WiTH nO SIgNIFiCAnt PaThOLUGIC ABNORmALITy. K. NOn-neOpLAsTic bReaSt witH FIBrocyStiC Changes, oUctAl epitheLial hypeRpLASiA, And FIBROADENOMATOID NODULES. Part 6: breast, Right medial new margin, eXcisiOn -- Breast tissue, negative for tumor. Part 7: breast, right Inferior new margin, excision - A.  fibroadipose tissue negative for tumor. FrAgMenTS OF SKeletaL muUSCLe. CASE SYNOPSIS:  SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST LATERALITY:  Right PROCEDURE: Segmental LOCATION: Not specified SIZE OF TUMOR:  Maximum dimension invasive component: 2.0 cm  MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: No TUMOR TYPE (invasive component): Ductal adenocarcinoma, NOS. NOTTIngham SCOre: Nuclear grade: 2 UUID:18E4043D-34BF-4CD1-9E2D-F906C7C78019 Tubule formation: 2 TCGA-BH-A0BT-01A-PR Redacted Mitotic activity score: 1 Total Nottingham score: 5 Nottingham grade (1, 2, 3): 1 ANGIOLYMPHATIC INVASION: Yes DERMAL LYMPHATIC INVASION: No CALCIFICATION:E No Tumor type, in situ: Cribriform DCIS admixed with invasive carcinoma Percent of tumor occupied by in situ component: 5 % SUrgICAl MArgINs iNVOLVED By inVASIvE COmpOnENT: No Distance of invasive tumor to closest margin: 6 mm Surg margins involved by in situ component: No Distance of in situ disease to closest margin: 12 mm LYMPH NODES POSITIVE: LYMPH NODES EXAMINED:  METHOD(S) OF LYMPH NODE EXAMINATION:  SentInel nOde metASTASiS:  H/E stain ONLy KERATIN POSITIVE CELLS ARE PRESENT: Yes SIZE OF NODAL METASTASES: No LYMPH NODE METASTASIS(-ES) WITH EXTRACAPSULAR EXTENSION: Diameter of largest lymph node metastasis: 1 mm SKIN INVOLVED (ULCERATION): No NON-NEOPLASTIC BREAST TISSUE: FCD No t Stage, pathologic: N stage, pathologic: pT1c m Stage, pathologiC: pN1mi EstrOgen reCepTORS: pMX PROGESTEROnE RECEPTORS: positive positive HER2/NEU: zero or 1+
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diff --git a/output/text/a8d8978d-fd00-4394-8c2b-f39b8904e53a.txt b/output/text/a8d8978d-fd00-4394-8c2b-f39b8904e53a.txt
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index 0000000000000000000000000000000000000000..e41bd53998ef3a5a44226e87bcd71ed59e0e46c6
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+Final Diagnosis Right kidney, partial nephrectomy (with frozen section): Papillary renal cell carcinoma. Fuhrman grade 3. Tumor size: 4.5 cm in greatest dimension. No angiolymphatic invasion. No capsular invasion. Margin is free of tumor. AJCC pathologic staging data: pT1b, NX. Right kidney margin: Negative for malignancy. Clinical Information Right lower lobe renal mass. Frozen Section Diagnosis FSA, Right partial nephrectomy - 6 x 5 x 4.5 cm segment of kidney, capsule intact. Margin inked black and capsule orange.. Sections show 4.5 x 4.5 x 4.0 cm yellow-red mass focally to within 0.2 cm of inked margin, sampled as FSA. Portion obtained. for EXPO study and remainder for permanents. Margins free Gross Description "NFsA." Received after frozen section is a 53 gram, 6.0 x 5.0 x 4.5 cm segment of kidney. The resection margin has been previously inked black and the capsule has been previously inked orange. The specimen has been previously sectioned to reveal a 4.5 x 4.5 x 4.0 cm yellow-red friable mass. The mass grossly appears to come to within 0.2 cm of the inked margin at. frozen section. A portion of the specimen has been submitted for frozen section in cassette "FSA,". "A1-A2," mass to include. resection margin; "A3," mass to include capsule. "B, Right kidney margin." Received are 3 kidney tissue fragments which are less than 1 gram and range from 0.9 to 1.5 cm in. greatest dimension. All of the tissue fragments will be inked black and submitted in toto. "B," all.
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diff --git a/output/text/a8f6c36b-67e4-4924-abdf-2a25fa07f9bb.txt b/output/text/a8f6c36b-67e4-4924-abdf-2a25fa07f9bb.txt
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index 0000000000000000000000000000000000000000..9aefc9ae74fe79fc6e69600a9e16b8b3be25adbe
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+--- Page 1 ---
+DEFARTUENT OP PATNOLOGY SURGICAL PATHOLOGY REPORT 1cs-0-3 aaterial 8 5o/3 Clinical Hitory! jntu fusirit C5o. Clinical 174 Dagnonia: Opersting CQcF: brst,N0S C50.9 Sargeon: Fathology Number Crcus Examination: The specimen is received in a single containe' labeled with the patient's name, history number, date and "right breast tissue". Receivea is a right breast weighing 982 grats. The breast measures 19.0  17.0 x 4.0 cm. in grentest dimensions and there is an axillary tail that measures l1.0  6.0  2.0 cm. in greatest dimensions. The skin ellipse on the surface of the breast is unremarkabl:. There is no evidence of induration or ulceration. The nipple is likewise unramarkable wit!; no retraction of the nipple, induration or ulceration. There Is no incision noted cn the skin ellipse. Palpation of the brcast revzals a firm nodule in the upper outer quadzant of the breast that measures 2.0  2.lt x1.5 cm. in greatest dimensions. The nodule is located in :he approximately ten o'clock position with relation to the nipple and measures 5.5 cm. from the nipple. On seetioning the mass is revealed to be firm ard whitish-tan. The iumor comes to within 3.5 cm. cf the deep margin of the specimen. Thie deep margin is grossly not involved by tumor. A seetion of the deep margin underneath the tu.nor is taken and placed in Block I. The tumor comes to within 0.5 cm. of the skin.. Sections cf the tumor are taken and placed in Blocks II, III, and IV. A section througn the nipple is placed in Bloek v. Serial sectioning of the remainder of the breast tissue does not reveal any other firm masses. A representative section from the lower outer quadrant is taken and placed in Block VI. A section from the lower inner quadrant is placed in Block VII! und a seetion from the upper inner quadrant of breast tissue is placed in Block vin. A section jf skin overlying the tumor is placed in Block IX. The axillary tail is divided into the standard three areas and Iymph nodes from the first area are placed in Blcek X. Lymph nodes from the seconu level are piaced in Bloek Xi. Lymph node candidates from the third. level are pleecd in Block Xli. Adderulum: it should be noted that tissue hus been sent Irom the tumor fer ER/PR receptors. UUID:5607C6CE-21D5-495E-9174-85F1E2E0CB9D TCGA-B6-A0RE-01A-PR Redacted DAGOS: *RIGHT BREAST, MASTECTOMY: A.) BREAST WITH INTRADUCTAL AND INFILTRATING DUCTAL CARCINOMA N.SA.B.P. NUCLEAR GRADR POORLY MYVERENTIATED HISTOLOGIC GRADE 3 OF 3. ARR FHEk OF TWMOR. MARGINK H.) SRVRRB DUCTAL, EPITHELIAL HYPRRPLASIA. C.) FOURTEKN AXILLARY LYMPH NODRS. NO CANCKR SEKN.
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diff --git a/output/text/a94f92e2-2767-45b9-b948-3b5c57c0cd2e.txt b/output/text/a94f92e2-2767-45b9-b948-3b5c57c0cd2e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..35616bc2e4654ccb8b6442e3a907c6a36c0d5a4c
--- /dev/null
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+--- Page 1 ---
+FINAL DIAGNOSIS: Part 1: breast AnD noDes, Leet, moDified Radical mastectomy --  INVASIVE DUCTAL CARCINQMA, NOTTINGhAm GRADE 3 (TUBULE FORmATION 3, NUCLEAR A. PLEOmORphISM'3, MITOTic ActIVITY 3, tOTal SCORE 9/9).  INVASIVE CARCINOMA MEASURES 2.2 CM (MICROSCOPIC MEASUREMENT).  INVASIVE CARCINOMA EXTENSIVELY INVOLVES NIPPLE PAPILLARY DERMIS UNDER THE BASAL LAYER Of the epidermis. . D. DUCTaL CARCInOmA IN SITU (DCIS), NUCLEAR GRADE 2, SOLiD TYPE, CONSTITUTES 2% OF tOTAL TUMOR MASS, ADMIXED WITH INVASIVE CARCINOMA. E. ALL RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA; INVASIVE CARCINOMA IS 1.1 CM TO THE CLOSEST MARGIN.E F. SIX OUT OF TEN AXiLLARy LYMPH nODES ARE POSiTiVE FOR METASTATIC CARCINOMA, WITH MULTIPLE AREAS OF EXTRACAPSULAR EXTENSION.S G.  mETASTATIC TUMOR MEASURES 2.5 Cm IN GREATEST DImENSION (RANGING FROM 0.7 Cm TO 2.5 CM). H.  NO DEFINITIVE LYMPHVASCULAR INVASION NOTED. FIBROCYSTIC CHANGES ARE PRESENT. Jcs-0-3 Part 2: lymph node, Left, biopsy - Caicnomn, nfi/nafhy ducfd, nos 85o0/3 A. FIBrOaDIPOSE TISSUE. S:h.busot,N0s C5o.9 3/r3|n pu B.  NO LYMPHATIC TISSUE IS IDENTIFIED. C. ENTIRE SPECiMEN SUBMITTED FOR MICROSCOPIC EXAMINATION. SYNOPTIC - PRIMARY iNVASIVE CARCINOMA OF BREAST LATERALITY: Left PROCEDURE: Modified radical mastectomy LocatIOn: Not specified SIZE Of TUmOR:  Maximum dimension invasive component: 2.2 cm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: No TUMOR TYPE (invasive component): Ductal adenocarcinoma, NOS NOTTINGHAM SCORE: Nuclear grade: 3 Tubule formation: 3 Mitotic activity score: 3 Total Nottingham score: 9 Nottingham grade (1, 2, 3): 3 ANGIOLYMPHATIC INVASION: No DERMAL LYMPHATIC INVASION: Not applicable CALCIFICATION: No TumOr tYpe, in SItu: Solid Percent of tumor occupied by in situ component: 2 % SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No SURG MARGINS INVOLVED BY IN SITU COMPONENT:E No LYMPH NODES POSITIVE: 6 LYMPH NODES EXAMINED: 10 mETHOD(S) OF LyMPH NODE EXAMINATION: H/E stain  SENTINEL NODE METASTASIS: Yes SIZE OF NODAL METASTASES: Diameter of largest lymph node metastasis: 25 mm LYMPH NODE METASTASIS(-ES) WITH EXTRACAPSULAR EXTENSION: Yes NON-NEOPLASTIC BREAST TISSUE: FCD t stage, pathologic: pT2 N Stage, pathologiC: pN2a m Stage, pathologIc: pMX ESTROGEN RECEPTORS: positive PROGESTERONE RECEPTORS: positive HER2/NEU: 2+ UUID:00C75246-4343-490D-9782-E6C0068C7782 TCGA-BH-A0B4-01A-PR Redacted M 3/13/1
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diff --git a/output/text/a9a1028e-602e-44ba-9524-15026e784537.txt b/output/text/a9a1028e-602e-44ba-9524-15026e784537.txt
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index 0000000000000000000000000000000000000000..d9d7a2da2bb9baeca9b7cdd40e959469839bcfd4
--- /dev/null
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+--- Page 1 ---
+Final Pathologic Diagnosis: A. Kidney, right, partial nephrectomy: Tumor histologic type: Papillary renal cell carcinoma, type 1 Sarcomatoid features (%): None Tumor size: 3.7 cm (greatest dimension) Other dimensions:. 3.5 x 2.2 cm Macroscopic extent of tumor:. Limited to kidney Focality: Unifocal Fuhrman grade: 2 of 4 Perinephric fat invasion: No Renal sinus invasion: Not applicable Renal vein involvement: Not applicable Adrenal gland present: No Cancer at resection margin:. No Pathologic findings in nonneoplastic kidney:  Not applicable (partial. nephrectomy) Hilar lymph nodes present: No Pathologic stage pT1a pNX pM: Not applicable B. Kidney, right, excision of deep margin: Negative for tumor. The examination of this case material and the preparation of this report were. performed by the staff pathologist. Gross Description: Received are two formalin filled containers each labeled with the patient name Part A is received additionally labeled "right renal mass" and consists of a 4 x 3.8 x 2.8 cm portion of apparent kidney with an abundant amount of associated perirenal fat. The surgical margin of resection is inked and step-sectioning reveals an apparent homogenous appearing tan mass without areas of significant hemorrhage or necrosis. This mass has dimensions of 3.7 x 3.5x 2.2 cm and which approaches to within 1 mm of the inked surgical margin of resection. Additionally noted is a 0.8 x 0.5 cm site of possible renal capsule traversed tumor to be confirmed microscopically. This area has been over inked with black ink. It is important to note that the specimen has been received in the gross room at having the perinephric fat previously stripped which may have. created artifactual disruption of this renal capsule (see cassette A1 and A2). Careful examination of the previously disrupted perinephric fat reveals no gross evidence of tumor involvement. Sections are submitted as follows: A1,2  representative sections of kidney with tumor and possible extracapsular extension to be confirmed microscopically;
+
+--- Page 2 ---
+A3-6  additional representative sections of kidney tumor approaching closest renal surgical margin of resection; A7,8 representative sections of grossly uninvolved perinephric fat. Gross photographs are taken. Part B is received additionally labeled "deep margin" and consists of a single portion of tan irregular soft tissue which is 1 x 0.4 x 0.2 cm submitted in toto in cassette B Microscopic Description: The final diagnosis of each specimen incorporates the microscopic examination findings. END OF REPORT
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diff --git a/output/text/a9b845cb-a78a-4440-8a31-0a2fe3e31fd8.txt b/output/text/a9b845cb-a78a-4440-8a31-0a2fe3e31fd8.txt
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index 0000000000000000000000000000000000000000..3472152be5ad7f0a14f51bccda12d5331f46b0f8
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+--- Page 1 ---
+Clinical Diagnosis & History:. Patient with renal mass. Specimens Submitted: 1: SP: Lt. kidney 2: SP: Para-aortic lymph node. 3: SP: Hilar lymph node DIAGNOSIS: 1) KIDNEY, LEFT; EXCISION:  RENAL CELL CARCINOMA, CHROMOPHOBE TYPE. THE TUMOR GREATEST DIAMETER IS 13.5 CM.THE TUMOR IS CONFINED WITHIN THE RENAL CAPSULE. NO INVASION OF THE RENAL VEIN IS IDENTIFIED. ALL SURGICAL MARGINS ARE FREE OF TUMOR THE NON-NEOPLASTIC KIDNEY SHOWS FIBROSIS AND FOCAL CHRONIC INFLAMMATION.TUMOR EXTENDS INTO THE RENAL SINUS.TUMOR BULGES INTO THE RENAL PELVIS BUT DOES NOT EXTEND INTO IT.THE ADRENAL GLAND IS NOT SUBMITTED. TUMOR SHOWS FOCAL NECROSIS AND HYALINZATION.VASCULAR INVASION PRESENT WITHIN THE RENAL SINUS. 2) LYMPH NODE, PARA-AORTIC; EXCISION: - ONE BENIGN LYMPH NODE (0/1). 3) LYMPH NODE, HILAR; EXCISION: - THREE BENIGN LYMPH NODES (0/3). I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Gross Descrintion: 1) The specimen is received fresh for frozen section and is labeled "Left kidney".  It consists of a kidney, with perinephric fat, portion of ureter and hilar vessels.  The adrenal gland not present. The overall dimensions of the specimen are 26 x 15 x 8.5 cm. The kidney weighs 1542 grams. The renal capsule strips off easily. The kidney measures 18 x 6.5 x 6.4 cm. Within the parenchyma of the kidney there is a yellow-tan mass measuring 13.5 in greatest dimension. The tumor appears to extend into the perirenal fat. The remainder of the renal parenchyma exhibits no abnormalities. The renal pelvis appears involve by tumor. The renal sinus appears involve by tumor. The renal vein appears uninvolved by tumor. The perirenal fat is unremarkable. The segment of ureter measures 4.2 cm in Length and is unremarkable.  Representative sections are submitted.. Summary of sections:. FSC - frozen section control T-tumor Page 1 of 2
+
+--- Page 2 ---
+TN-tumor and normal TC-tumor and capsule NK-normal kidney RP-rena! pelvis UM-ureteral margin VM-vascular margin 2) The specimen is received in formalin, labeled "Para-aortic lymph node". It consists of fibrofatty tissue fragments Entirely submitted. Summary of Sections: U - undesignated 3) The specimen is received in formalin, labeled "Hilar lymph node".  It consists of a single lymph node embedded in adipose tissue measuring 1 cm in greatest dimension. Entirely submitted. Summary of sections: U - undesignated Summary of Sectior. Part 1:SP: Lt.kidne Block Sect. Site PCs 1 FSC 1 1 NK 1 2 RP 2 5 T 5 1 TC 1 3 TN 3 1 UM 1 1 VM 1 Part 2:SP: Para-aortic lymph node Block Sect. Site PCs 1 U 1 Part 3:SP: Hilar lymph node Block Sect. Site PCs 1 U 1 Intraoperative Consultation:  Note:  The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS: RENAL CORTICAL CARCINOMA (VER) PERMANENT DIAGNOSIS:SAME. Page 2 of 2 END OF REPORT
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diff --git a/output/text/aa13e142-2265-473f-b7ea-3ae034912c0c.txt b/output/text/aa13e142-2265-473f-b7ea-3ae034912c0c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..71f8d97cab16789d8c0e7462f3267c2de26829ab
--- /dev/null
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+--- Page 1 ---
+4073B-A147-4E07-B3F2 A8LC-01A-PR Redac ted TCD-o-3 Corewono, pepilleey reno 8Q4D|3 aese SPECIMENS: A. RIGHT RENAL TUMOR BASE Stc R3idreyNsS Cb4.9 B. RIGHT KIDNEY TUMOR hJ i/24)13 SPECIMEN(S): A. RIGHT RENAL TUMOR BASE B. RIGHT KIDNEY TUMOR INTRAOPERATIVE CONSULTATION DIAGNOSIS: FSA-right renal tumor base: No malignancy identified. Diagnosis called by Dr. to Dr. at DIAGNOSIS: A. KIDNEY, RIGHT, TUMOR BASE, EXCISION: - NEGATIVE FOR CARCINOMA B. KIDNEY, RIGHT, PARTIAL NEPHRECTOMY: - PAPILLARY RENAL CELL CARCINOMA, TYPE 2 - TUMOR SIZE: 2.5 CM IN GREATEST DIMENSION - SURGICAL RESECTION MARGIN IS INVOLVED BY CARCINOMA - SEE SYNOPTIC REPORT COMMENT; The surface inked orange is not real margin as per conversation with Dr. on SYNOPTIC REPORT - KIDNEY (PARTIAL OR RADICAL) Specimens Involved Specimens: A: RIGHT RENAL TUMOR BASE B: RIGHT KIDNEY TUMOR Specimen Type: Partial nephrectomy Without adrenal gland Laterality: Right Tumor Site: Not specified Focality: Unifocal Tumor Size (largest tumor if multiple): Greatest dimension: 2.5cm Macroscopic Extent of Tumor: Tumor limited to kidney WHO CLASSIFICATION Papillary renal cell carcinoma 8260/3 Histologic Grade (Fuhrman Nuclear Grade): G2: Nuclei slightly irregular, approximately 15 u nucleoli evident Invasion of Vascular/Lymphatic: Absent Perinephric Tissue Invasion: Absent Margins: Margin(s) involved by invasive carcinoma Include: Renal parenchymal margin (partial nephrectomy only) Adrenal Gland: Not present Regional Lymph Nodes: None sampled Additional Findings:  None identified Pathological Staging (pTNM):  pT 1a N x M x Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition pMX: Cannot be assessed SUMMARY OF IMMUNOHISTOCHEMISTRY/SPECIAL STAINS Material: Block B2 Population: Tumor Cells Stain/Marker:Result:  Comment:
+
+--- Page 2 ---
+CYTOKERATIN 7 Positive CD 10 Positive Material: Block B5 Population: Tumor Cells Stain/Marker:Result:  Comment: RACEMACE Positive Carbonic Anhydrase IX  Positive Equivocal The interpretation of the above immunohistochemistry stain or stains is guided by published results in. the medical literature, provided package information from the manufacturer and by internal review of staining performance and assay validation within the. The use of one or more reagents in the above tests is regulated as an analyte specific reagent (ASR). These. tests were developed and their performance characteristic determined by the. They have not been cleared or approved by the U.S. Food and Drug Administration. The. FDA has determined that such clearance or approval is not necessary.. Special stains and/or immunohistochemical stains were performed with appropriately stained positive and/or negative controls. GROSS DESCRIPTION: A. RIGHT RENAL TUMOR BASE Received fresh labeled the patient's identification and "right renal tumor base" is a 0.3 x 0.2 x 0.1 cm piece of red-tan soft tissue; submitted in the frozen section diagnosis, FSA.. B. RIGHT KIDNEY TUMOR Received fresh labeled with the patient's identification and "right kidney tumor" is a 9 g, 3.7 x 2.5 x 1.3 cm piece of kidney with 1.3 x 0.5 x 0.5 cm piece of attached perinephric fat. The surface has a 1.5 x 1 cm defect. The specimen is oriented by Dr.. The true margin (surrounding the defect) is inked black and the remainder of the specimen is inked orange. On sectioning, there is a well-circumscribed mottled tan and brown nodule, 2.5 x 2.3 x 1.8 cm, which abuts the true margin. Photographs are taken and tissue is procured; submitted entirely, B1-B8. CLINICAL HISTORY: None Given PRE-OPERATIVE DIAGNOSIS: Right renal mass Gross Dictation:  Microscopic/Diagnostic Dictation: Final Review.., Pathologist Final: Pathologist.
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diff --git a/output/text/aa2727ca-6de6-4dda-bcbc-b24ae4f676dc.txt b/output/text/aa2727ca-6de6-4dda-bcbc-b24ae4f676dc.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6c025ffbdcef82bc34f308dbde2f74ed0f583723
--- /dev/null
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+
+--- Page 1 ---
+-C875B5384FF Redacted 1cs-0-3 lw 10/2,J1 Site: brast, Nos c5o.9 Final Pathologic Diagnosis: A. Sentinel lymph node #1, right axilla, biopsy: No carcinoma identified in one Iymph node (0/1).. B. Sentinel lymph node #2, right axilla, biopsy: No carcinoma identified in two lymph nodes (0/2).. C. Right breast, new inferior margin, excision: Benign breast tissue, no carcinoma identified. D. Sentinel lymph node #3, right axilla, biopsy: No carcinoma identified in one Iymph node (0/1).. E. Right breast, partial mastectomy: 1. Neuroendocrine carcinoma, large cell type, high grade, SBR grade 3, 3.8 cm diameter, extending to deep resection margin and 0.1cm from anterior/superior margin; see comment.. Page I of'6
+
+--- Page 2 ---
+Surgical Pathology Working Draft 2. Microcalcifications associated with benign breast tissue. F. Right breast, new posterior margin, excision: Benign breast tissue, no carcinoma. identified Note: Immunohistochemical studies were necessary to evaluate this case and establish the correct diagnosis. The following immunohistochemical stains were performed and evaluated:. Keratin cocktail:Patchy positive. CD56: Positive. PAX-5: Positive. LCA: Negative. Chromogranin: negative. Synaptophysin: negative. E-Cadherin: negative. The negative staining with LCA rules against a lymphoid neoplasm. Negative E-Cadherin excludes a ductal carcinoma. The positive staining with PAX-5, CD56 and patchy cytokeratin staining as well as the morphology onH& E stain are compatible with a neuroendocrine carcinoma. Negative staining with chromogranin and synaptophysin, although expected in this entity, does not exclude it.. Breast Tumor Synoptic Comment - Laterallty: Right. - Invasive tumor type: Large cell neuroendocrine carcinoma, high grade. - Invasive tumor size: 3.8 cm maximum diameter. - Invasive tumor grade (modified Bloom-Richardson): 3. Nuclear grade: 3 points. Mitotic count: 2 points. Tubule/papilla formation: 3 points. Total points and overall grade = 8 points- Grade 3. - Lymphatic-vascular invasion: Absent. - Resection margins for invasive tumor:. - Deep margin: Positive; (slide E12).. - Medial margin: Negative; (tumor is >1 cm away). - Lateral margin: Negative; (tumor is >1 cm away). - Anterior/superior margin: Close; (tumor is less than O.1 cm away, on slide E7) - Anterior/inferior margin: Negative; (tumor is 0.25 cm away, on slide E15). - Lymph node status: - Number of positive lymph nodes: 0. - Total number sampled: 4. - AJCc/UicC stage: pT2n0mX. An immunohistochemical test for estrogen and progesterone receptors as well as for HER2 was performed on block E9. The test for estrogen receptors is negative. There is no nuclear staining in any of tumor cells. Internal positive contro! is present.. The test for progesterone receptors is negative. There is no nuclear staining in any of tumor cells. Internal positive control is present.. Result of HER2/neu test: This carcinoma is negative for HER2/neu oncoprotein over-expression. An immunohistochemical assay was performed using the CB11 monoclonal antibody to HER2/neu oncoprotein. The staining intensity of this carcinoma was 0 on a scale of 0-3 (HER2 test interpreted Page 2 of 6
+
+--- Page 3 ---
+Surgical Pathology : Working Draft by Dr. Carcinomas with staining intensity scores of O or 1 are considered negative for over-expression of HER2/neu oncoprotein. Those with a staining intensity score of 2 are considered indeterminate. We and others have observed that many carcinomas with staining intensity scores of 2 do not show gene amplification. All carcinomas with staining intensity scores of 2 are therefore submitted for FisH testing. The results of the FIsH test are issued directly from the molecular cytogenetics laboratory. Carcinomas with staining intensity scores of 3 are considered positive for over-expression of HER2/neu oncoprotein. Tumors in this category show an excellent correlation between the results of Immunohistochemical and FIsh testing, and almost always show gene amplification. Intraoperative Consult Diagnosis FS1 (A) Sentinel lymph node #1, right axilla, biopsy: No carcinoma. (Dr. Fs2 (B) Sentinel lymph node #2, right axilla, biopsy: No carcinoma. (Dr.. FS3 (C) Right breast, new inferior margin, biopsy: No carcinoma. (Dr.. FS4 (D) Sentinel lymph node #3, right axilla, biopsy: Rare atypical cells in subcapsular space. (Dr. Clinical History The patient is a -year-old woman with post-operative diagnosis of breast cancer, who undergoes. sentinel lymph node biopsy and right partial mastectomy. Gross Description The specimen is received fresh in six parts, each labeled with the patient's name and medical record number. sists of one soft tan-yellow fatty. Part A, additionally labeled " tissue fragment measuring 2.5 x 1.1 x 0.4 cm. The specimen is trimmed, and one candidate lymph node is found. The lymph node is bisected. Touch preps and smear preps are made. The node is submitted for frozen section diagnosis 1 and subsequently submitted in cassette A1. The remaining yellow fatty tissue is submitted in cassette A2.  nsists of one soft tan-yellow fatty Part B, additionally labeled ". tissue fragment measuring 2.5 x 0.6 x 0.7 cm. The specimen is trimmed, and one large lymph node is found. The lymph node is bisected. Touch preps and smears are made. The node is submitted for frozen section diagnosis 2, and subsequently submitted in cassette B1. The remaining yellow fatty tissue is submitted in cassette B2. ," consists of one Part C, additionally labeled ". firm, unoriented, off-white/tan and yellow tissue fragment measuring 2.3 x 2 x 0.8 cm. The specimen is bisected at the long axis and one-half is submitted for frozen section diagnosis 3, and subsequently submitted in cassette C1. The remaining half is submitted in cassette C2.. nsists of one soft and firm pink-red Part D, additionally labeled ". unoriented tissue fragment measuring 0.8 x 0.7 x 0.4 cm. The specimen is bisected and touch preps and smears are made. The bisected node is submitted for frozen section diagnosis 4, and. subsequently submitted in cassette D1. onsists of an orlented, roughly ovoid Part E, additlonally labeied fragment of fibrofatty breast tissue containing a tirm palpable mass. The specimen is oriented with two surgical sutures, per the requisition sheet. The short suture is superior and the long suture is Iateral. Oriented as such, the specimen measures 5.7 cm from superlor to inferior, 6 cm from medial to lateral, and 3.6 cm from anterior to posterior. The specimen is inked for microscopic evaluation, with the anterior superior surface inked in blue, the anterior inferior surface inked in green, and the posterior surface inked in black. The specimen has been previously incised, prior to receipt in Pathology, and the sections removed from the aforementioned central mass. The specimen is serially Paor 3 nf6
+
+--- Page 4 ---
+Surgical Pathology - Working Draft sectioned in the sagittal plane into fifteen slices and numbered 1-15, medial to lateral. The medial slice (slice 1) is 0.9 cm in thickness. The lateral slice (slice 15) is 0.9 cm in thickness. The remainder of the slices averages 0.4 cm in thickness. Serial sectioning reveals a firm, tan-white, nodular lesion, which spans serial slices 2-14. This multilobulated mass measures 3.8 cm from superior to inferior, 3 cm from anterior to posterior, measured in slice 7. The mass grossly approaches the posterior margin in slices 6-8. The mass is 0.2 cm from the anterior superior margin in slice 4 and 0.8 cm from the anterior margin in slice 7. The medial and lateral margins are grossiy clear (>1 cm). Representative sections are submitted as follows: Cassette E1: Mediat margin, slice 1 (representative perpendicular section). Cassette E2: Medial one-third, slice 2 (medial-most extent of lesion). Cassette E3: Superior posterior, slice 4. Cassette E4: Superior anterior, slice 4. Cassette E5: Anterior superior, slice 5. Cassette E6: Superior posterior, sllce 5. Cassette E7: Anterior superior, slice 7. Cassette E8: Superior posterior, slice 7. Cassette E9: Anterior inferior, slice 7. Cassette E10: Inferior posterior, slice 7. Cassette E11: Anterior superior, slice 8. Cassette E12: Superior posterior, slice 8. Cassette E13: Anterior superior, slice 11. Cassette E14: Superior posterior, slice 11. Cassette E15: Anterior inferior, slice 11. Cassette E16: Inferior posterior, slice 11. Cassette E17: Superior half, slice 14. Cassette E18: Inferior half, slice 14. Cassettes E19-E20: Media! portion of lateral margin, slice 15 (perpendicularly sectioned).. Part F, additionally labeled consists of a grossly unremarkable fragment of fibrofatty breast tissue sutured to Telta and oriented by two surglcal sutures, per the specimen container labels. The short stitch is superior and the long stitch is Iateral. Oriented as such, the specimen measures 4.5 cm from superior to inferior, 3.7 cm from medial to lateral, and 1.6 cm from anterior to posterior. The specimen is inked for microscopic evaluation, with the anterior superior surface inked in blue, the anterior inferior surface inked in green, and the posterior surface inked in black. The specimen is serially sectioned from medial to Iateral into ten slices. These are numbered 1-10, from medial to lateral. The specimen is grossly unremarkable on serially sectioning. The entire specimen is submitted as follows:. Cassette F1: Slice 1. Cassette F2: Slice 2. Cassette F3: Slice 3. Cassette F4: Slice 4. Cassette F5: Slice 5. Cassette F6: Slice 6. Cassette F7: Slice 7. Cassette F8: Slice 8. Cassette F9: Slice 9. Cassette F10: Slice 10. /Pathology Resident 'Pathologist Signed: Fee Codes: Pase4 of6
+
+--- Page 5 ---
+Surgical Pathology - Working Draft Other Specimens. -Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: A: Right chest wall tumor (fresh), B: Subclavian vein margin. Final Diagnosis A. Right chest wall, tumor, excision: Metastatic high-grade neuroendocrine carcinoma, 7.5 cm; see comment. B. Subclavian vein, margin, biopsy: Segment of vein with chronic inflammation, no tumor; see comment.. pecimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received:e Final Diagnosis Review of slides from. Right breast, upper outer quadrant, biopsy: Neuroendocrine carcinoma, large-cell type, high-grade; see comment. Right anterior chest wall, fine-needle aspiration: Consistent with metastatic neuroendocrine carcinoma; see comment. .Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: A: Surgical scar right breast, B: New anterior superior margin right breast, C: New deep margin, D: New anterior inferior margin. Final Diagnosis A. Skin, right breast surgical scar, excision: Scar with mild chronic inflammation and foreign body giant cell reaction, no tumor. B. Right breast, new anterior superior margin, excision: Scar with chronic. inflammation, foreign body reaction, and fat necrosis, no tumor.. C. Right breast, new deep margin, excision: 1. Scar with chronic inflammation, foreign body reaction, and fat necrosis, no tumor. 2. Microcalcifications associated with benign ducts.. D. Right breast, new anterior inferior margin, excision: 1. Scar with chronic inflammation, foreign body reaction, and fat necrosis, no tumor. 2. Microcalcifications associated with benign ducts. Pan 5 nF F
+
+--- Page 6 ---
+Surgical Pathology - Working Draft FND OF RFPORT Pase 6 of 6
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diff --git a/output/text/aa342b76-27e3-4863-b89b-a01094b39e35.txt b/output/text/aa342b76-27e3-4863-b89b-a01094b39e35.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5dc244b0e21b38dd574b316561515aa2a7e0515c
--- /dev/null
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+
+--- Page 1 ---
+UUID:045B2852-E1FF-4376-8F39-60FC940224D0 TCGA-AN-A04C-01A-PR Redacted TSS Patient ID Case #: DOB: jex: Female Ethnicity (Race): Cancer Sample Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma Date of Procurement: !. Anatomic Site: Left Breast Tumor location: Primary Tissue Specification: Tumor Specimen Matrix: Tissue Specimen Format: OCT Container: block Type of Procurenent: Radical mastectomy Grade: 2 T Stage: 2 N Stage: 1 M Stage: 0 Treatment: none Treatment Details: n/ae Normal Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw Matrix: Blood Specimen Format: frozen Container: tube Date of Procurement:. 1cs-0-3 saui onu,nifiltruHmq duct,Nos 85oc|3 Sife: brast, nos. c50.9 10/31)11 W-tof%rft!
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diff --git a/output/text/aa40b04c-13f6-495e-9050-81e8590ba85a.txt b/output/text/aa40b04c-13f6-495e-9050-81e8590ba85a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..38c3426ed9936ed98fa4a978cdbfd06754307170
--- /dev/null
+++ b/output/text/aa40b04c-13f6-495e-9050-81e8590ba85a.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+Page 1 of 6 UUID:82129FB4-5062-4878-931D-C09C336EAE4A TCgA-XF-A9T4-01A-PR Redacted DIAGNOSIS: RADICAL CYSTOPROSTATECTOMY WITH PELVIC LYMPH NODE DISSECTION AND ORTHOTOPIC URINARYS DIVERSION TO URETHRA: TDs3 RIGHT DISTAL URETER (AFS) : FROZEN SECTION DIAGNOSIS: 8it Y8addu nkEb7.9 8120|3 NO HIGH GRADE ATYPIA OR TUMOR IDENTIFIED FINAL DIAGNOSIS: BENIGN URETER NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED LEFT DISTAL URETER (BFS) : t>3|2b)j y FROZEN SECTION DIAGNOSIS: NO HIGH GRADE ATYPIA OR TUMOR IDENTIFIED FINAL DIAGNOSIS: BENIGN URETER NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED RIGHT COMMON ILIAC LYMPH NODES (C):  NO MALIGNANCY IDENTIFIED IN FOUR LYMPH NODES EXAMINED (0/4) PRE SACRAL LYMPH NODES (D) : NO MALIGNANCY IDENTIFIED IN SEVEN LYMPH NODES EXAMINED (O/7) RIGHT EXTERNAL ILIAC LYMPH NODES (E) : NO MALIGNANCY IDENTIFIED IN EIGHT LYMPH NODES EXAMINED (O/8) RIGHT LYMPH NODE OF CLOQUET (F) :) NO MALIGNANCY IDENTIFIED IN THREE LYMPH NODES EXAMINED (O/3) RIGHT OBTURATOR/HYPOGASTRIC LYMPH NODES (G): METASTATIC CARCINOMA IDENTIFIED IN ONE OF SEVEN LYMPH NODES EXAMINED (1/7) RIGHT PARA CAVAL LYMPH NODES (H) : NO MALIGNANCY IDENTIFIED IN TWO LYMPH NODES EXAMINED (O/2) APICAL URETHRAL MARGIN (IFS) : INTRAOPERATIVE FROZEN SECTION DIAGNOSIS: NO HIGH GRADE ATYPIA OR TUMOR IDENTIFIED FINAL DIAGNOSIS: BENIGN PROSTATIC URETHRAL TISSUE  NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED BLADDER/PROSTATE (J) : BLADDER : EXOPHYTIC INVASIVE POORLY DIFFERENTIATED UROTHELIAL CARCINOMA (3.3 X 2.5 X 2) CM). GRADE 3-4/4, LARGELY REPLACING RIGHT URETEROVESICAL JUNCTION (WITHOUT OBSTRUCTION), EXTENDING INTO DEEP MUSCULARIS PROPRIA AND APPROACHING BUT NOT INVOLVING PERIVESICAL SOFT TISSUE NO LYMPHOVASCULAR INVASION SEEN NO UROTHELIAL CARCINOMA IN SITU (FLAT LESION) IDENTIFIED RANDOM BLADDER MUCOSA INCLUDING TRIGONE AND BLADDER NECK, NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED RESECTION MARGINS, FREE OF UROTHELIAL DYSPLASIA AND MALIGNANCY PROSTATE: FOCAL HIGH GRADE PROSTATIC INTRAEPITHELIAL NEOPLASIA (PIN II-III) NO PROSTATIC ADENOCARCINOMA IDENTIFIED
+
+--- Page 2 ---
+Page 2 of 6 PROSTATIC URETHRA, NO UROTHELIAL DYSPLASIA OR UROTHELIAL MALIGNANCY IDENTIFIED BILATERAL SEMINAL VESICLES, NO SIGNIFICANT HISTOPATHOLOGIC CHANGE LEFT PARA AORTIC LYMPH NODES (K) :) NO MALIGNANCY IDENTIFIED IN THREE LYMPH NODES EXAMINED (O/3) LEFT COMMON ILIAC LYMPH NODES (L) :) NO MALIGNANCY IDENTIFIED IN THREE LYMPH NODES EXAMINED (O/3) LEFT EXTERNAL ILIAC LYMPH NODES (M) : NO MALIGNANCY IDENTIFIED IN FIVE LYMPH NODES EXAMINED (O/5) LEFT LYMPH NODE OF CLOQUET (N) : NO MALIGNANCY IDENTIFIED .IN TWO LYMPH NODES.EXAMINED (0/2) LEFT OBTURATOR/HYPOGASTRIC LYMPH NODES (O): NO MALIGNANCY IDENTIFIED IN 12 LYMPH NODES EXAMINED (0/12) LEFT PRESCIATIC LYMPH NODES (P): NO MALIGNANCY IDENTIFIED IN ONE LYMPH NODE EXAMINED (O/1) [ENTIRELY SUBMITTED] RIGHT PRESCIATIC LYMPH NODES (Q): NO MALIGNANCY IDENTIFIED IN FOUR LYMPH NODES EXAMINED (O/4) RIGHT PROXIMAL URETER (R):  BENIGN URETER NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED LEFT PROXIMAL URETER (S) : BENIGN URETER NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED LYMPH NODE SUMMARY: METASTATIC CARCINOMA IDENTIFIED IN ONE OF 61 LYMPH NODES EXAMINED (1/61) PATHOLOGIC TNM STAGE: pT2bN1MX COMMENT: Representative sections of invasive carcinoma are submitted for p53 assay by immunohistology, results of which will be issued in an addendum.. SPECIMEN SOURCE: AFS: "Rt distal ureter" BFS: "Left distal ureter F/S" C: "Rt common iliac LN" D: "pre sacral LN" E: "Rt external iliac LN" F: "Rt LN of cloquet" G: "Rt obturator/hypogastric LN" H: "Rt para caval LN" IFS: "Apical urethral margin-f/s" J: "Bladder/prostate""
+
+--- Page 3 ---
+Page 3of 6 K: "Left para aortic LN". L: "Lt. common iliac LN" M: "Lt. external iliac LN" "Lt. LN of Cloquet" N: 0: "Lt. obturator/hypogastric LN". P: "Lt. presciatic LN" Q: "Rt. presciatic LN" R: "Rt. proximal ureter" S: "Lt. proximal ureter" CLINICAL INFORMATION: Pre-Op Dx: Bladder cancer. Post-Op Dx: Same as pre-op GROSS EXAMINATION: A: The specimen is received fresh from the O.R. and labeled "Rt distal ureter". It consists of a segment of ureter that measures 0.3 cm in length by. 0.3 cm in diameter. Entirely submitted for frozen section in cassette AFs.. B:  The specimen is received fresh from the O.R. and labeled "Left distal ureter F/s". It consists of a segment of ureter that measures 0.4 cm in length by 0.3 cm. in diameter. Entirely submitted for frozen section in cassette BFs. C: The specimen is received in formalin and labeled "Rt common iliac LN". It consists of a single tan-yellow piece of fatty tissue measuring 2.5 x 2 x 0.6 cm. Entirely submitted in one cassette.. D: The specimen is received in formalin and labeled spre sacral LNn. It consists of a single tan-yellow to purple piece of fatty tissue measuring 4.5 x 2 x 1 cm. Multiple lymph nodes are identified ranging from 0.3 to o.7 cm in greatest dimension. Entirely submitted in three cassettes.. E: The specimen is received in formalin and labeled "Rt external iliac LN". It consists of multiple tan-yellow pieces of fatty tissue measuring 5 x 3.5 x l.5 cm in aggregate.  Multiple lymph nodes are identified, the largest measuring 2.2 cm in greatest dimension. ~Entirely submitted in four cassettes.. F: The specimen is received in formalin and labeled "Rt LN of cloquet".. It consists of a single tan-yellow piece of fatty tissue measuring 2.5 x 1.5 x 1 cm. A single lymph node is identified measuring 1.2 cm in greatest dimension. Entirely. submitted in one' cassette.. G: The specimen is received in formalin and labeled "Rt obturator/hypogastric LN". It consists of multiple pieces of tan-yellow fatty tissue measuring 4.5 x 4 x 1 cm in aggregate.  Multiple lymph nodes are identified, the largest node measures 1.3 x 1 x 0.6 cm. Entirely submitted in three cassettes.. H: The specimen is received in formalin and labeled "Rt para caval LN". consists of a single tan-yellow piece of fatty tissue measuring 3 x 1.5 x 1.5 cm. One lymph node measuring 0.s cm in greatest dimension is identified. Entirely submitted in two cassettes.. I: The specimen is received fresh from the O.R. and labeled "Apical urethral margin-f/s". It consists of a single piece of tan-pink tissue measuring 2 x 0.4 x 0.3 cm. Entirely submitted for frozen section in cassette IFs. J: The specimen is received fresh from the O.R. and labeled "Bladder/prostate".. consists of a radical cystoprostatectony specimen measuring overall 22 x 13.5 x 2.5 cm. The attached peritoneum measures i6 x 13 x 0.1 cm and is yellow-tan,
+
+--- Page 4 ---
+Page 4 of 6 glistening and freely mobile. *The non-peritonealized surface is inked black with. red ink superimposed along the right side of the prostate.  The specimen is opened anteriorly along the prostatic urethra and anterior bladder wall.  The bladder measures 5 x 6 x 3 cm with a wall thickness of 1.3 cm. The right attached ureter measures 4.5 cm in length and 1.1 cm in circumference with a normal pink-tan mucosa. The left attached ureter measures 5.3 cm in length and 0.6 cm in circumference with a tan-pink normal appearing mucosa. Located at the right ureterovesical junction is a tan-pink, raised, soft, polypoid mass measuring 3.3 x 2.5 x 2 cm. It completely encircles without obstructing the ureterovesical junction on the right side. Sectioning through the mass shows full wall thickness involvement with possible extension into perivesical fat..  The wall in the involved area measures 2 cm in thickness. The remaining bladder mucosa appears tan-pink and. is unremarkable. No other lesions are identified. The prostate measures 3 x 4.5 x 3.5 cm. The prostatic urethra measures 2.5 cm in length and 1.6 cm in circumference and is not excavated.  The verumontanum measures 0.7 x 0.5 x 0.4 cm. The prostate is serially sectioned..  The cut surfaces appear tan and unremarkable. The left seminal vesicle measures 3 x 1.5 x 0.8 cm, and the right seminal .vesicle measures 3 x 1.8 x 0.8 cm.  Both appear normal. Representative sections are submitted in 30 cassettes.. K: The specimen is received in formalin and labeled "Left para aortic LN". It consists of a single tan-yellow piece of fatty tissue measuring 2 x 1.5 x 1 cm. One Iymph node measuring 1 cm in greatest dimension is identified. Entirely submitted in one cassette. L: The specimen is received in formalin and labeled "Lt. common iliac LN". It consists of multiple pieces of tan-yellow fatty tissue measuring 2.5 x 2 x 1 cm in aggregate. Multiple  lymph nodes ranging from 0.3 cm to 0.5 cm in greatest dimension are identified." Entirely submitted in one cassette. M: The specimen is received in formalin and labeled "Lt. external iliac LN". It consists of multiple pieces of tan-yellow fatty tissue measuring 4 x 2.5 x 1. cm in aggregate.  Multiple lymph nodes are identified, the largest measuring 1.2 cm in. greatest dimension. Entirely submitted in two cassettes.. N: The specimen is received in formalin and labeled "Lt. LN of Cloquet". It consists of a single tan-yellow piece of fatty tissue measuring 1.5 x 1 x 1 cm. One lymph node measuring i cm in greatest dimension is identified. Entirely. submitted in one cassette.. O: The specimen is received in formalin and labeled "Lt. obturator/hypogastric LN". It consists of multiple pieces of tan-yellow fatty tissue measuring 4 x 3.5 x. 1.5 cm in aggregate. Multiple lymph nodes ranging from 0.3 to 1.5 cm in greatest dimension are identified. Entirely submitted in three cassettes.. P: The specimen is received in formalin and labeled "Lt. presciatic LN". It consists of multiple pieces of  tan-yellow fatty tissue measuring 3 x 2 x 0.6 cm in. aggregate. Entirely submitted in one cassette. Q: The specimen is received in formalin and labeled "Rt. presciatic LN". It consists of multiple pieces of tan-yellow fatty tissue measuring 2 x 1.5 x 0.5 cm in aggregate. Muitipie small lymph nodes ranging from 0.3 to o.4 cm in greatest dimension are identified. Entirely submitted in one cassette. R: The specimen is received in formalin and labeled "Rt. proximal ureter". It consists of a segment of ureter measuring 1 cm in length and 0.3 cm in diameter. The proximal end is submitted in one cassette. S: The specimen is received in formalin and labeled "Lt. proximal ureter". It consists of a segment of ureter measuring 0.9 cm in length and 0.3 cm in diameter.
+
+--- Page 5 ---
+Page 5of 6 The proximal end is.submitted in one cassette SECTIONS: AFS: frozen section, right distal ureter BFS: frozen section, left distal ureter c: right common iliac lymph nodes - all embedded D1-3: presacral lymph nodes - all embedded E1-4: right external iliac lymph nodes.- all embedded F: right lymph node of Cloquet - all embedded G1: right obturator/hypogastric lymph nodes; largest lymph node. bisected G2,3 : remaining tissue H1,2: right paracaval lymph nodes - all embedded IFs: J1-10: bladder/prostate; bladder tumor at right ureterovesical junction J11: tumor.edge and.adjacent mucosa J12: anterior bladder wall J13: right lateral bladder wall J14: dome of bladder J15: left lateral bladder wall J16: left ureterovesical junction J17: posterior bladder wail J18: trigone and bladder neck J19: right perivesical fat for possible lymph nodes J20 : left perivesical fat for possible lymph nodes J21 : right distal pxostate J22: left distal prostate J23 : right mid prostate J24 : left mid prostate J25,26 : right anterior, posterior proximal prostate J27,28 : left anterior, posterior proximal prostate J29,30: right and left seminal vesicles and prostatic junction K: left para-aortic lymph nodes - ali embedded L: left common iliac lymph nodes - ali embedded M1,2: left external iliac lymph nodes - all embedded N: left lymph node of Cloquet - all embedded 01-3: left obturator/hypogastric lymph nodes - all embedded P: left presciatic lymph nodes - ail*embedded Q: right presciatic lymph nodes - - all embedded R: right proximal ureter S: left proximal ureter INTRAOPERATIVE FROZEN CONSULTATION: AFS: Right distal ureter:  no high grade atypia or tumor identified BFs: Left distal ureter:  no high grade atypia or tumor identified IFS:  Apical urethral margin:  no high grade atypia or tumor identified MICROSCOPIC EXAMINATION: A-I: See final microscopic-diagnosis.
+
+--- Page 6 ---
+Page 6 of 6  Sections of the bladder show a deeply invasive poorly differentiated urothelial. J: carcinoma (J1-11). The tumor extends almost but not completely through the muscularis propria of the bladder wall (J3) where it approachea without involving the perivesical soft tissue. No associated in situ carcinoma (flat lesion) is seen. around the invasive tumor or in additional random sections of the bladder. All resection margins are free of both urothelial dysplasia and invasive carcinoma. K-s: See final microscopic-diagnosis. T CeA tumn contuis 1s% Agvnnouo. hiifu114
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diff --git a/output/text/aa4a9b30-2f93-4b86-b6d4-6c609460d3c1.txt b/output/text/aa4a9b30-2f93-4b86-b6d4-6c609460d3c1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..40d7d5eeb56b528b3d66c65d4e0c5011f05de510
--- /dev/null
+++ b/output/text/aa4a9b30-2f93-4b86-b6d4-6c609460d3c1.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+ENT INFORMATION RMATION UUID: B6841E65-9EFD-4F60-A4F0-68270AC39015 TCGA-FV-A4ZP-01A-PR Redacted SPECIMEN INFORMA HION Accession # Aoct / Reg #: SURGICAL PAThOLOgy REPORT DIAGNOSIS DIAGNOSIS: A. Sott tissue (abdominal nodule), blopsy: Benign soft tissue with tat necrosis and fibrosis. B. Liver (lett lobe), wedge resection: Hepatocellular carcinoma, moderately differentiated, with vascular invaslon, and extension to the inked surgical excision margin. C. Galibtadder, cholecystectomy: Benign gallbiadder with mild chronic cholecystitie; cholelithiasis. D. Liver (additional loft lobe), blopsies: Hepatocellular carcinoma with vascular Invaslon; tumor appears to extend to the cauterized edges ot the biopsy. IA  hee reviewed the siver sections and concurs with the diagnosis of hepatocellular carcinomas.. The histomorphoiogy and the irmmunostains support a diagnosis of hepatocelluler carcinoma in spite of the negative Hepar stain. The reason for the negative stain is not evident as both the intemal and extemal controls stained appropriately. Meianoms and adrenal cortical carcinoma are the two other diagnostic considerations. Melanoma is exctuded by the negative Melan-A and S-1o0; adrenal cortical carcinoma is excluded by the constellation of  morphology and immunostaining results.  CLINICAL INFORMA JION CLInICAL. HISTOry:  Preoperative Diagnosis: Hepatocellular carcinoma Postoperative Diagnosis: 1cs-0-3 Symptoms/Radiologic Findings: Cmcirmr, hgntcllulw,Nvs 817Uf3 SPECIMENS: A. Abdominal nodule, rule out METS S.tx : liner C21.0 B. Left liver lobe C. Gabladder hw D. Additional ieft lobe Iive? uJ4/1> Gross Description: SPECIMEN DATA A. The first container A is labeled . A and abdominal nodule rule out METS and consists of a yelow-tan nodule measuring 1.0 x 1.0 x 0.5 cm.. The spscimen is bisectod. One-half of the specimen was examined at the time of surgery. The specinen is subsequently entirely submitted in cassettes .. as follows: frozen soction--1; remainder of specimen--2. B. The second container 8 is labeled.  grams. The surface is gray to red-tan with areas of hemorrhegic adhesions. There are multiple gray-tan nodulos measuring from 1.0 x 1.0 x 0.7 cn to  and lef lobe fiver and consists of a portion of liver measuring 15.0 x 11.0 x 7.0 am and weighs 393. 11.0 x 10.0  2.0 cn. The nodules appear to invoive approximately 90% of the liver parenchyna. The surgical resected margin has been inked. There are surgical clips present at the surgical margin surrounding are two possible ducts. One of the possible duct appears to have tumor protruding through the lumen and is visible at the surgical margin. On sectioning the cut surface is paie tan feshy mutilobuiar with areas of homorrhage. There is abso an  ares of fbrous bands surrcunding yellow-tan firm tissue. The mass appears focaly less than 0.1 cm from the resected margin in the previously  mentioned area of possible duct. There is a rim of normal liver parenchyma that is yeilow to browm-tan. Attached ta one edge of the liver is a portion af indicate the specific loction fron where the biopry was takea. The image ud dingran ss oot ioteded iorephace s comoles reading of the hinal repoet. Page: 1of2
+
+--- Page 2 ---
+ SPECIMEN INFORMATION PATIENT INFORMATION #broadipoee tissue that is yeliow tan hemorrhagic measuring 6.0 x 2.0 x 1.0 can. On sectioning there is a ressel, 2.0 cm in iength and 0.3 cm in diameter that appears to show tumor within the lumen. Represontative sections were taken for genomic studies and placed in oranga cassetes labeled  Representative sections are submitted in cassettes 100807 A:D. Also recaived are.two cassettes, one yeilow and one green, iaboied I Pas folows: perpendicular section from margin in relationship to mass from possibls ducts--1 and 2; additional perpendicufar sections from margin in relationship to mass- : sections trom vessel near the resected-8; submitind portion of vessel with tumor-10. C. The third container C is iabeled cien, C and galibladder and consists of an intact galibladder. measuring 7.0 x 3.0 x 2.0 cm. The surface is gray. tan to purpla gray with adhesions. The galibladder wall measures 0.2 cn. The lining is velvety and bile stained. There are calculi identifiod. Representative sections are submitted in a singlo cassette D. The fourth container D is tabeked Ah, D and additional laft labe liver and cansiats of three separate brown-tan fragments of tiver meesuring 1.0 x 0.5 x 0.5 cm to 2.0 x 1.0 x 0.5 cm. The surfaces shows marked cautery artifact. The two larger pieces have been bisocted and the specimen is entrely submitted in cassettee 1 Mas foBows: smal fragment--1; second fragment bisected-2; third fragnent bicected--3. InTRA-OPERATiVE CONsULTATION: FSA: 'Negative for malignancy, fibrous tissue, infiammation' per  MICROSCOPIC'EXAMINATION: Section A, labeled "abdominal nodule" shows an area of fat necrosis with tibrosis. No metastatic malignancy is identified. Sectlons of the wedge biopsy of the loft lobe of the liver, speckmen B, shows multiple expanse isle nodules consisting of cords, nests, and trabeclar structures of a large cell malignant neaplasm having the architectural and cytologic characteristics of hepatocellular carcinoma. The tumor celis have large vesicular nuclei with prominent nuceoli, with scattered intranuclear cytoplasnic inclusions, and a moderate to large smount of pink, granular cytoplasn. Scattered mitoses are easily identified and there are occasional bl and multinucleated tumor cells with bizzare giant nuciear forms. These features are in sharp contrast to the adjacent normal fiver. There is evidenca of vascular invasion by the tumor. Tumor appears present at the inked surgical margins. A battary of immunohistochemical stains shows the turnor cells staining with CAM5.2 and focally with cytokeratin 20. A CD10 is done on biocks B3, 4, 7, and 8 and shows prominent staining cf bite canalicxl. A polyclona! CEA is uninterprstabla as it is over stained. The tumor cels are Immuno nogative with S100 prctein, Melan-A, cytokeratin 7, alpha-fetoprotein, and Hopar antigen. Control slides statned appropriately. Addtionaly,  reticulin stain periormed on block B3 shows an absence of reticulin in the tumor, in contradistinction to its presence in the adjacent normal liver. Section C shows a galbladder with mild chronic cholecystitis. There is no morphoioglc evidence of malgnancy, either primary or metastatic. Sections from specinon D. labelod "additional loft lobe of liver" disckosed nodutes of hepatoceluiar carcinoma in a fibrous stroma. Iron stains-show no stored iron. Trichrane stains highight a number of thkkened fibrous trabeculae coursing through the tumor. A reticulln stain shows a general lack of reticuin within the tunor proper. HIPAA Disc Dual/s DISQUALIFIS END
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diff --git a/output/text/aa66e95c-5ca9-42dc-97e4-a17b0eaf62bb.txt b/output/text/aa66e95c-5ca9-42dc-97e4-a17b0eaf62bb.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5a2cd8e49728f8b606d88a9279380850a6e24b89
--- /dev/null
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+
+--- Page 1 ---
+Formatted Path Report LARGE INTESTINE TISSUE CHECKLIST Specimen type: Abdominal perineal resection Specimen size: Not specified Tumor site: Sigmoid colon Tumor size: 7.5 x 0 x 0 cm Tumor features: Ulcerated Histologic type: Adenocarcinoma Histologic grade: Moderately. differentiated Tumor extent: Pericolonic tissues Lymph nodes: 3/12 positive for metastasis (Adjacent fatty tissue 3/12) Margins: Uninvolved. Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None
+
+--- Page 2 ---
+Date of Procurement
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diff --git a/output/text/aa7ba8b5-64dd-4f25-a193-afa878798a13.txt b/output/text/aa7ba8b5-64dd-4f25-a193-afa878798a13.txt
new file mode 100644
index 0000000000000000000000000000000000000000..54adbaba162bf93ca0655550692f95a4053a5f13
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+
+--- Page 1 ---
+Examination: Histopathological examination. CGA-D5-6536 Material: 1. Multiple organ resection - sigmoid colon with rectum and two tumours. Physician In charge: Material collected on  Material received on Expected time of examination. Clinical diagnosis: Bi-focal cancer of the large intestine (sigmoid colon and rectum) SPECiMEN - sigmoid colon with. rectum and two tumours. Proximal end marked with wire.. Examination performed on:. Macroscopic description:e A 32 cm length of intestine with fat tissue sized 32 x 6 x 2 cm. A cauliflower-shaped tumour sized 5 x 3 x 2.5 cm found in the mucosa. The lesion surrounds 1o0% of the intestine circumference, narrowing its lumen; removed 10 cm from the proximal incision and 11 cm from the distal incision. The lesion penetrates macroscopically the intestine wall and the fat tissue. Minimum side margin is 1.1 cm. A second tumour seized 2.5 x 3 x 1 cm located 5 cm away from the first one, removed 22 cm from the proximal.  boundary and 3 cm from the distal one. The tumour penetrates the intestinal wall; side margin 2.5 cm.. Microscopic description:. Adenocarcinoma tubulopapillare partim mucinosum (G3). Infiltratlo carcinomatosa tunicae muscularis priopriae et telae adiposae pericollcae. MInimum side margin is 1.1 cm. Intestine ends free of neoplastic lesions. Outside tumour 1: Adenocarcinoma tubulopapillare Gl. Infltratio carcinomatosa tunicae muscularis priopriae et adiposae pericolicae. Lymphonoduiitis reactiva lymphonodorum (No XIv).. Histopathological diagnosis:. Adenocarcinoma tubulopapillare partim musinosum coli bifocale. Tubulopapillar and partiallymucinous bifocal. adenocarcinoma'of the colon.(G3, Dukes B, Astler - Coller B2, pT3, pNO).
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diff --git a/output/text/aa934f3c-4043-445a-88d6-94ad9f05d4e9.txt b/output/text/aa934f3c-4043-445a-88d6-94ad9f05d4e9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..203ed30150f245a74ea58891a290edd1f3bb0ec6
--- /dev/null
+++ b/output/text/aa934f3c-4043-445a-88d6-94ad9f05d4e9.txt
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+
+--- Page 1 ---
+SPECIMENS: A. LT RAD NEPRECTOMY & RETRO PERITONEAL LYMPH NODES DIAGNOSIS: LEFT KIDNEY, ADRENAL AND RETROPERITONEAL LYMPH NODES, RADICAL NEPHRECTOMY: - PAPILLARY RENAL CELL CARCINOMA. TYPE 2. FUHRMAN NUCLEAR GRADE 3 - TUMOR SIZE 6.5 cm. - CARCINOMA EXTENSIVELY INVADING INTO RENAL HILAR ADIPOSE TISSUE - VASCULAR LYMPHATIC SPACE INVASION IDENTIFIED.  - CARCINOMA FOCALLY INVADING INTO VASCULAR WALL, BUT NOT IN LUMEN, OF RENAL VEIN. - LARGE MATTED HILAR LYMPH NODE (11 CM) AND THREE ADDITIONAL SMALLER LYMPH NODES, EXTENSIVELY REPLACED BY METASTATIC CARCINOMA (4/4). - URETERAL AND VASCULAR MARGINS, NEGATIVE FOR TUMOR.  ADRENAL GLAND, NO TUMOR SEEN. - SEE TEMPLATE AND NOTE. NOTE: There is focal necrosis and focal cystic degeneration identified in the tumor. No sarcomatoid. component is seen. Several small tumor nodules are present at the periphery of the main tumor, and. some of those nodules represent metastatic tumors in the angiolymphatic spaces. The metastatic tumor in the hilar lymph nodes shows perineural invasion. A panel of immunohistochemical stains was performed to rule out possible collecting duct carcinoma. The tumor is positive for CK20, RCC, EMA, and Cam5.2. It is negative for ULEX Europaeus agglutinin, HMW-CK, Vimentin, CK7 and CEA. There is weak stain of CK19, probably due to non-specific stain.. KIDNEY NEOPLASM TEMPLATE Specimen type: Radical nephrectomy, left, with adrenal gland Tumor site: Lower pole Tumor size: 6.5 x 6.1 x 5.5 cm. Tumor subtype: Papillary renal cell carcinoma, type 2. Histologic grade (Fuhrman's): Grade 3 Invasion Vascular/Lymphatic: Present Perinephric Tissue Invasion: Present Margins of resection: Margins free Adrenal gland: Uninvolved by tumor  Regional lymph nodes: Positive, the largest matted lymph node is 11 cm. (4/4) Stage: T3aN2 Primary tumor (T) TX: Cannot be assessed TO: No evidence of primary tumor. T1: Tumor <7.0cm in greatest dimension limited to the kidney T2: Tumor >7.0cm in greatest dimension limited to the kidney T3: Tumor extends into major veins or invades the adrenal gland or perinephric tissues but not beyond Gerota T3a: Tumor invades the adrenal gland or perinephric tissues but not. beyond Gerota's fascia T3b: Tumor grossly extends into the renal vein(s) or vena cava below the diaphragm T3c:  Tumor extends into vena cava above the diaphragm or invades the wall of the vena cava. T4: Tumor invades beyond Gerota's fascia. Regional Lymph nodes (N) N1: Metastasis to single lymph node N2:  Metastasis to more than one lymph node. SPECIMEN(S): A. LT RAD NEPRECTOMY & RETRO PERITONEAL LYMPH NODES
+
+--- Page 2 ---
+GROSS DESCRIPTION: A. LEFT RADICAL NEPHRECTOMY AND RETROPERITONEAL LYMPH NODES Received fresh in a container labeled with patient name and "left radical nephrectomy and. retroperitoneal lymph nodes" is a kidney and perinephric adipose measuring 15 x 7.5 x 7.0 cm together. The kidney alone measures 12 x 6 x 5 cm and has a 6 cm long, 0.6 cm diameter proximal ureter. At the renal hilum is a 15 x 5 x 4 cm portion of fibroadipose, nodular lymph nodes and probable tumor. Sectioning of the renal parenchyma reveals an inferior pole 6.5 x 5.5 x 6.1 cm firm, tan mass with irregular edges. Surrounding the main tumor mass the renal parenchyma contains multiple, small nodules of tumor that appear to be separate from the primary mass. Portions of the tumor cut surface show necrosis and hemorrhage. The tumor invades hilar adipose and encases the renal artery and vein at the hilum. There is no tumor present in the lumen of vascular margins. Tumor also encases proximal ureter, but the ureter is probe patent. Tumor obliterates the renal pelvis. The 3.0 x 2.5 x 1.0 cm adrenal gland is hemorrhagic but uninvolved by tumor. Tumor appears to penetrate renal capsule only towards the renal hilum. There does not appear to be penetration of Gerota's fascia. Remaining renal parenchyma has a reasonably well defined cortico-medullary junction. Sectioning of the hilar soft tissue reveals that it is largely replaced by an 11 x 4.5 x 3.5 cm lobulate mass of tumor that is contiguous with the tumor in the kidney. Additionally, at the periphery of this main mass are multiple <0.5 cm separate, tan, well circumscribed nodules of tumor probably representing lymph nodes with metastatic disease. A1: urethral and vascular margins. A2-A8: renal tumor including extension into the hilar adipose and encasement of hilar. vascular and ureteral structures A9: a section of kidney adjacent to tumor with small tumor nodules. A10: hilar mass. A11-A12: possible metastatic disease in hilar lymph nodes. A13: adrenal
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diff --git a/output/text/aa9d479d-714e-465c-9c62-e5fc9e4a65a7.txt b/output/text/aa9d479d-714e-465c-9c62-e5fc9e4a65a7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0c0a41ce64d5c96c399bfc44e8b97768eea44d8c
--- /dev/null
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+
+--- Page 1 ---
+JUID:B537A19C-C7E8-42EB-BA3F-673417F3A9BA 4X-01A-PR Redactedd ) Final Diagnosis y25/+ Breast, right,simple mastectomy: Invasive ductal and lobular carcinoma (mixed features), Nottingham grade II (of III) (tubules 2/3, nuclei 2/3, mitoses 1/3; Nottingham score 5/9], forming a mass, 2.1 x 1.4 x 1.3 cm, with associated biopsy site changes, located in the superior/central region of the breast [AJCC pT2]. A second biopsy site is present in the subareolar region. A separate nodule of ductal carcinoma in situ, 0.6 x 0.6 x 0.5 cm, is present in the upper inner quadrant. Lobular carcinoma in situ is identified. The tumor does not involve the nipple, overlying skin, or underlying chest wall. All surgical resection margins, including the deep margin, are negative for tumor (minimum tumor free margin, 0.5 cm, anterior/superior margin). Lymph nodes, right axillary sentinel, excision: Multiple (7) right axillary sentinel lymph nodes are negative for metastatic carcinoma [AJCC pN0 (i-) (sn)]. Blue dye is not identified in any of the seven right axillary sentinel lymph nodes. Immunohistochemical cytokeratin stain was performed on the paraffin embedded sentinel lymph node tissue and confirms the H&E impression. Breast, left, simple mastectomy: Mild proliferative changes characterized by ductal hyperplasia without atypia. The prior biopsy site is identified. The nipple is without diagnostic abnormalities.. Estrogen and progesterone receptor analysis and Her-2/NEU have been ordered on paraffin-embedded tissue. Jcs-0-3 c arcn omn, mfittnut'ng ductel nd 1obul 85aQ/3 Situ: bresst Nos c5o.9hws 4fos/u
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diff --git a/output/text/aaee70ea-4ccf-4ec8-8d65-d6c8771a4288.txt b/output/text/aaee70ea-4ccf-4ec8-8d65-d6c8771a4288.txt
new file mode 100644
index 0000000000000000000000000000000000000000..48efe1c9f2a339a30fbc581731dea6372976f8be
--- /dev/null
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+
+--- Page 1 ---
+1c0-0-3 Carcinoma, mfl+natwg duct, Nos 850of3 c 50.9 Sih Codu: brenst, nos 1+/2f10 h Final Diagnosis Breast, left, wide local excision: Infiltrating ductal carcinoma, Nottingham grade III (of III), [tubules 3/3, nuclei 3/3, mitoses 2/3; Nottingham score 8/9], forming a 2.0 x 1.8 x 1.5 cm circumscribed mass with central fibrosis [AJCC pT1c]. Focal (5%) high grade ductal carcinoma in situ with necrosis is present outside the main tumor mass. Angiolymphatic invasion is absent. The non-neoplastic breast parenchyma shows nonproliferative fibrocystic changes. Calcifications are present in malignant ducts. Biopsy site changes are present. All surgical resection margins, after a single separately submitted re-excision of the anterior/inferior margin, are negative for tumor (minimum tumor free margin, 0.7 cm, superior margin). Lymph nodes; left axillary sentinel Nos. 1, 2, and 3; sentinel biopsies: A single (of 3) left axillary sentinel lymph node (SLN No. 1) is positive for isolated tumor cell cluster [AJCC pN0 (i+) (sn)]. This isolated tumor cell cluster measures 0.11 mm and is seen on cytokeratin and H&E staining. Blue dye is identified in all three sentinel lymph nodes. Immunohistochemical cytokeratin stain was performed on the paraffin embedded sentinel lymph node tissues and confirm the H&E impression. Lymph node, left axillary, excision: A single nonsentinel lymph node is negative for metastatic carcinoma. UUID: 01D97550-C616-4001-85A5-5502D35FA38E TCGA-AR-A1AY-01A-PR Redacted
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diff --git a/output/text/aaf097a9-8cc4-4299-8ac9-bc67b4f15b34.txt b/output/text/aaf097a9-8cc4-4299-8ac9-bc67b4f15b34.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d5d5639460fd3653ce5a2bcea736bb664bd494e3
--- /dev/null
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+DIAGNOSIS TOTAL LARyNGECTOMY: INVASIVE POORLY DIFFERENTIATED SQUAMOUS CARCINOMA WITH EXTENSIVE PERINEURAL INVASION AND VASCULAR LYMPHATIC INVASION, INVOLVING THE PIRIFORM SINUS AND LEFT SUPRAGLOTTIC REGION. Margins of resection free of tumor.. (b) LEFT BASE OF TONGUE MARGIN: Skeletal muscle, no tumor present.. GROSS DESCRIPTION (A)  TotAL LARyngecromy - A tota7 laryngectomy specimen,  9.0 (s-I) x 6.5 (L-R) x 4.67 (A-p) cm. There is a roughened red supraglottic tumor present on the Teft side, involving the pyriform sinus. It appears to extend toward the midline and may cross over the midline approximately 1.0 mm. This tumor is 2.7 (M-L) x 2.5 (s-1) cm in size. There is no extension through the base of the epiglottis or the thyroid cartilage, grossly. There is no involvement of the glottic or subglottic areas. No thyroid tissue is included with this Taryngectomy specimen. INK coDe: ' Black - peripheral mucosal margin and anterior aspect of epiglottic remnant. Secrion code:  A1, anterior right mucosal margin (12-2 o'clock, en face,. for frozen section);_A2, right mucosal"margin (2-4:30),_en face for frozen;. A3, posterior mucosal margin (4:30-7:30), en face; A4,'left posterior mucosal margin (7-9 o'clock), en face; A5, left lateral mucosal margin (9 o'cTock-10:30), en face; A6, 1eft' anterior mucosal margin (io:30-12 o'clock), en face; A7, A8, perpendicular sections of superior (12 o'clock), tissue for deep margin, frozen section; A9, sections of right true and false vocal cord; A10,  left section of true and false vocal cord; Al1-Al5, perpendicular radial sections of the left supraglottic area, going from posterior' to midline; A17, radial section, anterior midline, supraglottic area; A18-A23, radial sections of the right supraglottic area..  going from midline to posterior. Reserve. tissue is available. *Fs/DX:  TNVASIVE SQUAMOUS CELL CARCINOMA, MUCOSAL AND DEEP MARGINS, FREE OF TuMOR. (B) LEFT BASE OF TONGUE MARGIN, INK AT TRUE MARGIN - An irregular fragment of tan soft tissue (2.9 x 1,5 x 0.4 cm). One side of the specimen is previously inked blue designating the true margin. The true margin is re-inked in black. Specimen is serially. sectioned and submitted in b1 and b2, frozen section, perpendicular margin Page 1 of 2 History Case Pathology Report History Case Pathology File under: Pathoiogy
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+*Fs/dX: SKELETAL MUSCLE, NO TUMOR PRESENT. SNOMED CODES M-80703 T-24100 Page 2 of 2 History Case Pathology Report History Case Pathology File under: Pathology
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+) 10(2+j# UUID:0C0EEC9F-A715-4769-B58C-99D06C3C91F3 Redacted 1 c s -0 -3 cicioma, infi1traHng duct, nvs 85ovJ3 Site: brsst, Nos. C50.9 10/21)  Final Pathologic Diagnosis:. A. Sentinel lymph node #1, left axilla (count-4414), biopsy: Metastatic ductal carcinoma, 2 cm focus, in one (1/1); see comment. B. Lymph node, left axilla, dissection: Metastatic ductal carcinoma in two of fourteen (2/14). Page I of ?
+
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+Surgical Pathology  Working Draft C. Lymph node, left axilla level III, biopsy: No tumor in one (0/1). D. Left breast, modified radical mastectomy:. 1. Invasive ductal carcinoma, SBR grade 3, 6.5 cm; see comment.. 2. Ductal carcinoma in situ (Dcis), high grade, micropapillary and cribriform patterns, with comedonecrosis, narrowly excised; see comment.. 3. Invasive carcinoma present at inked anterior-superior resection margin; see comment. 4. Microcalcifications in Dcis. 5. Non-proliferative fibrocystic change with apocrine metaplasia and microcysts. 6. Benign sclerosing papilloma. E. Left breast, anterior/superior/medial margin, excision: Invasive ductal carcinoma, SBR grade 3, close to inked margin; see comment.. F. Skin, left breast nodule, excision:. 1. Invasive ductal carcinoma, SBR grade 3, present in dermis, subcutaneous tissue and fibrous tissue; see comment.. 2. Fibrous tissue, suggestive of scar, with invasive tumor; see comment.. G. Skin, newest anterior/superior/medial margin, excision: No significant pathologic abnormality, no tumor. H. Left breast, new nipple margin, biopsy: Benign lactiferous ducts, no in situ or invasive tumor. I. Non-sentinel lymph node #1, dissection: No tumor in two (0/2). J. Non-sentinel lymph node #2, biopsy: No tumor in one (0/1).. Note: The tumor present In the main mastectomy specimen (part D) encompasses a 7.5 cm maximal area, which includes an area of tumor satellites adjacent to a 6.5 cm solid tumor mass. The tumor consists of infiltrating trabeculae, nests and glands of cells with ample and mostly clear cytoplasm, and large pleomorphic nuclei with nucleoli. Abundant mitotic figures are present. Ductal carcinoma in situ is also present with cribriform, micropapillary, and comedo patterns, and shows cytology similar to that of invasive tumor, with cells showing clear cytoplasm and pleomorphic high-grade nuclei. The DCis is present only as scattered foci admixed within the invasive carcinoma itself. Material from the patient's prior biopsy (. ) shows analogous features. Invasive carcinoma are present at the inked anterior-superior margin of the main specimen (slides D2 D3; see details In synoptic below), however, the separately submitted additional margin (part E), shows invasive tumor that is narrowly (<0.5mm) excised (slide E8). In this specimen (part E), there is also tumor extending to the edges of the specimen that were indicated by the surgeon as not the new margin. The skin nodule (part F) shows invasive ductal carcinoma (0.6 cm) within the subcutaneous tissue, dermis and immediately beneath the epidermis, where it is seen to involve an area of fibrosis that is suggestive of a skin scar. The tumor is within O.5 mm of the excision margin, however, the separately submitted new skin margin (part G) shows no tumor.. The extensive clear cell features and nested architecture of the tumor are morphologic features that are often seen in renal cell carcinoma (Rcc). Therefore, this possibility was considered and immunohistochemical studies were performed and evaluated on a lymph node metastasis (block B7) and interpreted as follows: Paor? nf 7
+
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+Surgical Pathology -. Working Draft. CD10: Negative (result does not support renal tumor). Renal cell carcinoma Ab (Rcc): Positive (result supports renal tumor). Cytokeratin 7: Positive (result does not support renal tumor). E-Cadherin: Positive (result does not support renal tumor). Estrogen receptor: Negative (result does not support renal tumor). Overall, while Rcc Ab is positive, all other stains are indicative of this being metastatic breast carcinoma in a lymph node that has features mimicking RCC. Breast Tumor Synoptic Comment - Laterality: Left.. - Invasive tumor type: Invasive ductal carcinoma.. - Invasive tumor size: 6.5 cm maximum diameter (calculated by the presence of tumor in 4 consecutive 1.6 cm thick slices) - Invasive tumor grade (modified Bloom-Richardson): 3. Nuclear grade: 3, 3 points. Mitotic count: >30 mitotic figures/10 HPF, 3 points.. Tubule/papilla formation: >10% but <75%, 2 points.. Total points and overall grade = 8 points = grade 3. - Lymphatic-vascular invasion: present.. - Perineural invasion: None identified.. -Tumor necrosis: Present. - Resection margins for invasive tumor: In the main mastectomy specimen (part D), invasive tumor is present at the inked anterior/superior margin, near the medial end (approximately 10 o'clock, 10 cm from the nipple; slides D2, D3). However, the separately submitted "anterior/superior/medial" margin shows tumor that is narrowly excised near one edge of the "new margin" of specimen part E (< 0.5 mm; slide E8). - Deep margin: Negative; (tumor is 1 cm away, on slide D6). - Medial margin: Negative; (tumor is 0.2 cm away, on slide D1). - Lateral margin: Widely clear. - Anterior/superior margin: Positive on main specimen (slides D2, D3). - Anterior/inferior margin: Widely clear.. - Nipple bed margin: Widely clear. - Ductal carcinoma in situ (Dcis) type: Comedo, cribriform, micropapillary. - Ductal carcinoma in situ size: Dcis is present as scattered foci admixed with the invasive carcinoma. - Ductal carcinoma in situ nuclear grade: High nuclear grade. - Necrosis in DCis: Comedonecrosis, focal (<1/3). - Microcalcifications: Present, involving Dcis only. - Resection margins for ductal carcinoma in situ: In the main mastectomy specimen (part D), DCiS is o'clock, 10 cm from the nipple; slide D2). However, the separately submitted "anterior/superior/medial" margin has no definite Dcis in it. - Deep margin: Widely clear; (tumor is 1 cm away, on side D6). - Medial margin: Negative; (tumor is 0.2 cm away, on slide D1). - Lateral margin: Widely clear. - Anterior/superior margin: Close; <0.5mm (sllde D2). - Anterior/inferior margin: Widely clear.. - Nipple bed margin: Widely clear. - Lobular carcinoma in situ (LCIS): Not present. - Lymph node status: Positive. - Number of positive lymph nodes: 3. - Total number sampled: 19. - Diameter of largest metastasis: 2 cm.. - Extranodal extension: Not present. - AJCC/UICC stage: pT3N1aMX. Page 3 of 7
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+Surgical Pathology - Working Draft - Nontumorous breast tissue: Cystic changes, apocrine metaplasia, papilloma. -Nipple: Not present. - Skin/dermis: Focus of invasive ductal carcinoma in dermis (see part F above).. An immunohistochemical test for estrogen and progesterone receptors was performed on block A1 (lymph node). The test for estrogen receptors is positive. There is strong nuclear staining in >7o% of tumor cells. The test for progesterone receptors is positive. There is at least weak nuclear staining in >10% of tumor cells, with strong staining in ~5% of tumor nuclel.. Result of HER2/neu test: This carcinoma Is indeterminate for HER2/neu oncoprotein over-expression. An immunohistochemical assay was performed on block A1 using the CB11 monoclonal antibody to HER2/neu oncoprotein. The staining intensity of this carcinoma was 2 on a scale of 0-3 (HER2 test interpreted by Dr. Carcinomas with staining intensity scores of O or 1 are consldered negative for over-expression of HEr2/neu oncoprotein. Those with a staining intensity score of 2 are considered indeterminate. We and others have observed that many carcinomas with staining intensity scores of 2 do not show gene amplification. All carcinomas with staining Intensity scores of 2 are therefore submitted for FisH testing. The results of the FIsH test are issued directly from the molecular cytogenetics laboratory. Carcinomas with staining intensity scores of 3 are considered positive for over-expression of HER2/neu oncoproteln. Tumors in this category show an excellent correlation between the results of immunohistochemical and Fish testing, and almost always show gene amplification. Intraoperative Consult Diagnosis FS1 (A) Sentinel Ivmnh node #1, left axilla, biopsy: Carcinoma, approximately 2 cm (1/1). (Dr. Clinical History The patient is a vear-old woman with left breast cancer. She undergoes mastectomy.. Gross Description The specimen is received in ten parts, each labeled with the patlent's name and unit number. Parts A-C are received fresh. Parts E-J are received in formalin.. Part A, additionally labeled " isists of a single, pink, unorlented tissue fragment measuring 2 x 1.8 x 0.6 cm. The specimen is bisected and entirely submitted for frozen section diagnosis 1, and subsequently submitted in cassette A1.. Part B, additionaily labeled " consists of a brown-yellow, ovoid piece of fatty tissue with a stitch indicating the apex, measuring 8.5 x 8.5 x 3.3 cm. Also in the specimen container are two fragments of yeliow-tan, soft tissue measuring 5.5 x 4.5 x 2.5 cm in aggregate. Multiple lymph nodes are found in the specimen. Lymph nodes from the main specimen are submitted from apex to base and all lymph nodes are submitted as follows:. Cassettes B1-B6: Multiple whole lymph nodes. Cassette B7: One lymph node, bisected. Cassette B8: Multiple whole lymph nodes from smaller tissue fragment.. Part C, additionally labeled nsists of two fragments of tan-yellow, fatty tissue measuring 3.5 x 3.5 x 2.5 cm in aggregate. No lymph nodes are identified in the specimen. The specimen is entirely submitted in cassettes C1-C3.. It Part D is additionally labeled consists of a mastectomy, without skin, nippie, or areoia, that has been previously inked and incised prior to recelpt in Pathology. Short suture and long suture are present, in additional to a biue nylon suture present at the anterior-mid area. Following the provided orientation, the specimen measures Paor 4 nf 7
+
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+Surgical Pathology - Working Draft 22 cm from medial to lateral, 19 cm from superior to inferior, and 6 cm from anterior to posterior. The designated nipple/areolar bed measures 3.5 x 3.5 cm in area. The specimen has been previous!y inked as follows: posterior aspect in black, anterior superior blue, and anterior inferior green. A 14 cm long previous incision is present on the posterior surface running vertically that is 5 cm deep and reveals an irregular firm area in the superior half of the cut surface (upper inner quadrant). The specimen is further serially sectioned, from medial to lateral, with slice 1 as medial and slice 13 as lateral and the previous incision present between slice 5 and slice 6. An irregular, ill-defined, firm, white-to- tan lesion is present In slices 1 through 6, encompassing a 8 cm dimension from mediat to Iateral, 5 cm from superior to inferior, and 2.5 cm from anterior to posterior. The majority of this Iesion is present as a solid area in slices 3 through 6 (6.5 cm from medlal to lateral). In slices 1 and 2, the lesion is present as an area of multiple satellite nodules, of up to 0.4 cm each, directly adjacent to the solid area. The lesion overall abuts the anterior- superior margin and is 0.5 cm from medial margin, 1.2 cm to deep margin, 3 cm to anterior inferior, 13 cm to lateral, 2.5 cm to the nipple bed 3.4 cm to superior edge, and 8.5 cm to inferior edge. Two 0.5 cm, spherical cystic cavities are present within or adjacent to the lesion, the first in the superior half of slices 4 and 5, and the second in the mid-portion of slice 5. Up to a 0.5 cm thickness of muscie is present in focal areas of the posterior aspect. Remainder of the specimen consists almost entirely of unremarkable yellow fat. There are thin, delicate strands of white, fibrous tissue present throughout most of the remainder of the specimen. Representative sections are submitted as follows: Cassette D1: Representative medial margins, perpendicular.. Cassette D2: Anterior-superior margin, slice 2, in relatlon to nodular masses. Cassette D3: Anterior-superior margin, slice 3, in relation to mass. Cassette D4: Anterior-superior margin, slice 4, including cavity.. Cassette D5: Deep margin in relation to mass, from slice 5.. Cassette D6: Deep margin, slice 6, with muscle. Cassette D7: Superior edge, slice 4.. Cassette D8: Inferior edge, slice 5. Cassette D9: Anterior-inferior margin, slice 5.. Cassette D10: Nipple bed margin, slice 6. Cassette D11: Lateral margin, perpendicular. Cassette D12: Representative section of the mass from slice 5, with cavity. Cassette D13: Inferior edge of mass, slice 6.. Cassette D14: Representative upper outer quadrant, slice 8. Cassette D15: Representative upper outer quadrant, slice 10. Cassette D16: Representative lower inner quadrant, slice 6.. Cassette D17: Representative lower inner quadrant, slice 4.. Cassette D18: Representative lower outer quadrant, slice 9.. Cassette D19: Representative lower outer quadrant, slice 8.. t consists of a segment of Part E is additionally labeled. adipose tissue containing a siligie suture. The requisition form indicates the suture marks the new margin. The specimen is 4.5 x 4 x 2 cm with the suture present at one longitudinal end of the specimen. There is a 1.5 cm maximal dimension area containing Irregular, white-firm mass that is 2 cm from the new margin. In addition, there are 2-3 0.2 to 0.3 cm firm nodules present abutting the new margin. The new margin is inked black. The remainder of the surfaces are inked blue and representative sections including the entire new margin are submitted as follows: Cassettes E1-E8: Entire new margin.. Cassette E9: Representative section of 1.5 cm lesion.. Part F is additionaily labeled. It consists of a skin ellipse that is 1.2 x 0.6 cm in area and 0.8 cm in maximal depth, that contains an irregular O.5-cm area of firm, white nodules. The resection margins are inked blue and the specimen is entirely submitted as follows: Cassette F1: Tips. Cassette F2: Remainder of specimen.. It consists of a 1.4 Part G is additionally labeled. x 1.1 x 0.2 cm segment of tissue with apparent skin on one oroau suuace. A 0.7 cm central hole is present. . The non-skin surfaces are inked blue and the specimen is entirely submitted as follows: Page 5 of 7
+
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+Surgical Pathology - Working Draft Cassette G1: Tips. Cassettes G2-G3: Remainder of specimen. Part H is additionally labeled It consists of a segment of irregular, brown soft tissue sutured to a Telfa pad. There is a single long suture present on the non-Telfa surface. The requisition form indicates the stitch marks new margin (margin side up) and this new margin surface is inked black. The opposite surface (Telfa surface) is inked blue. The specimen is bisected and entirely submitted in cassette H1.. Part I, additionally labeled consists of one soft and firm, tan-yellow piece of fatty tissue. measuring 2.5 x 2 x 0.6 cm. The specimen is trimmed and extensively searched for lymph nodes. One candidate lymph node is found; this is inked blue and bisected, and entirely submitted in cassette I1. The remaining yellow fatty tissue is submitted in cassette I2.. Part J, additionally labeled consists of one soft and firm, tan-light brown tissue fragment measuring 2 x 1.6 x 0.7 cm. The specimen is inked black and bisected, and entirely submitted in cassettes J1-J2. The immunonernvidaca et=in(s) reported above were developed and their performance characteristics determined by the ! They have not been cleared or approved by the U. S. Food and Drug Administration. Ine FOA has determined tnat sucn ciearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded as Investlgational or for research.' This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 ("CLIA") as qualified to perform hlgh-complexity clinica! testing.. /Pathologist Signed: Fee Codes: Other Specimens Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Final Diagnosis Review of A. Left breast, "#1 with calcs," biopsy: 1. Ductal carcinoma in situ, high grade, solid and papillary patterns with comedo necrosis and extension to lobules; see comment.. 2. Microscopic focus (< 1mm) suspicious for invasion; see comment. 3. Microcalcifications present in association with ductal carcinoma in situ. B. Left breast, "#2 with calcs," biopsy:. 1. Invasive ductal carcinoma; see comment.. 2. Ductal carcinoma in situ, high grade, solid and papillary patterns with comedo necrosis and extension to lobules; see comment.. 3. Microcalcifications present in association with ductal carcinoma in situ and stroma. Paze 6 of 7
+
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+Surgical Pathology - Working Draft A. Left breast "nodule," biopsy: 1. No in situ or invasive carcinoma identified. 2. Fibroadenoma.. FND OF RFpORT Paor 7 nf ?
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+ics-0-3 Carcnonn, mfilfrtiwr ductnl, Nos s85ot/3 Site : Busst.N0s c50.9 Diagnosis: 5. Moderately differentiated invasive ductal carcinoma (tumor diameter: 3.8 cm) with focal intraductal components and focal angioinvasion. UUID:93D66EAD-B7D3-4688-8EC9-75C4380619D9 Redacted CGA-A8-A092-01A-PR
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diff --git a/output/text/ab38ad3b-fa68-4ace-a9f4-10473a82b346.txt b/output/text/ab38ad3b-fa68-4ace-a9f4-10473a82b346.txt
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index 0000000000000000000000000000000000000000..f30562e4bba7c2221f4733ae252a6fe7d5f5aee3
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+UUID:F136F750-09F6-45E4-A2D9-58748D4F1799 TCGA-IA-A40X-01A-PR Redacted Results SURGICAL PATHOLOGY (Orden Patient info Patient Name Sex DOB Results Specimen #1 Submitting Physician: FINAL DIAGNOSIS 1cD-o-3 renal ceif carci noma,papi1lar 8a00f si+: Kidn,n0s. CQ4,9 8-3-jz R0 1. Left kidney,. partial nephrectomy (A) - Renal cell carcinoma, papillary type 1 (3.5 cm in greatest dimension), nuclear Furhman grade 2 of 4. (See comment) - The tumor is confined to the kidney. - Vascular invasion is not identified.  The parenchymal and capsular/soft tissue margins of resection are negative for tumor. 2. Left adrenal gland, adrenalectomy (B) - Unremarkable adrenal gland.. COMMENT Procedure:  Partial nephrectomy Specimen Laterality: Left Tumor Site: (select all that apply): Upper pole. Tumor Size (Greatest dimension): 3 cm Tumor Focality: Unifocal Macroscopic Extent of Tumor: Tumor limited to kidney. Histologic Type: Papillary renal cell carcinoma. Sarcomatoid Features: Not identified Tumor Necrosis: (any amount) (Optional): Not identified. Histologic Grade: (Fuhrman Nuclear Grade) 2/4 Microscopic Tumor Extension: (select all that apply): Tumor limited to. kidney Margins: (select all that apply): Margins uninvolved by invasive carcinoma. Lymph-Vascular Invasion: Not identified Pathologic Findings in Nonneoplastic Kidney: Patchy interstitial chronic Dana 1 ^f 2
+
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+Encounter Date: inflammation; multifocal clear cell changes. Pathologic Stage (pTNM) : pT1a NX MX By immunoperoxidase staining the tumor is positive for AmAcR and ck7 and negative for wT-1 and cD 57, supporting the above diagnosis. ANALYTE SPECIFIC REAGENT (ASR) DISCLAIMER This test was developed and its performance characteristics determined by the The U.s. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. (Electronic Signature) SPECIMEN SUBMITTED A: PARTIAL KIDNEY B: LEFT ADRENAL CLINICAL DATA LEFT RENAL MASS INTRAOPERATIVE CONSULT DIAGNOSIS A. Encapsulated neoplasm. Margin is grossly negative (gross diagnosis only). ( GROSS DESCRIPTION A. Received fresh at the frozen desk labeled "partial nephrectomy" is a segment of kidney measuring 4.0 x 3.5 x 3.0 cm and weighing 26.7 grams. Renal artery, vein, pelvic and ureter are not present in the specimen. A 3.5 x 3.2 x 3.0 cm tan soft encapsulated tumor mass is present within the specimen. The tumor bulges the renal capsule and extends to 0.1 cm from the capsular/soft tissue margin (inked blue). The mass is 0.1 cm from the parenchymal margin of resection (inked black). After gross inspection with the surgeon, a possible frozen section was canceled at the surgeon's request because the parenchymal margin was grossly negative for tumor. Sections are submitted as follows: Al tumor; A2 uninvolved kidney; A3 tumor with parenchymal and capsular/soft tissue margin; A4 tumor with parenchymal margin; A5-A6 tumor with capsular/soft tissue.. B. Received fresh labeled "left adrenal" is a specimen consisting of an adrenal gland measuring 8 x 4.5 x 1 cm and weighing 20.8 grams. No masses are palpated. The specimen is inked black and serially sectioned. Sectioning reveals unremarkable adrenal parenchyma. Representative sections are submitted in B1-B4. Patient ID #: DOB:  "(Age: Date of Report: Page 2 of 3
+
+--- Page 3 ---
+Encounter Date: Date of Procedure: Date of Receipt: Submitted by: Location: Test performed by: Lab and Collection SURGICAL PATHOLOGY (Order : ) on?  - Lab and Collection Information Resuit History SURGICAL PATHOLOGY (Order Jon -- Order Result History Report. Result Intormation Result Date and Time Status Provider Status Final result Reviewed tatus: This result is currently not released to Display Full Result Report Display Order Report Page 3 nf 3
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index 0000000000000000000000000000000000000000..04bf45265df390cc8a6b4da17171320389396328
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+CGA-B9-4116 SURGICAL PATHOLOGY Surgical Pathology Report Accession #: Diagnosis: Left kidney and ureter, nephroureterectomy Histologic tumor type/subtype: Renal cell carcinoma, papillary typetype1) Histologic grade (if applicable): Fuhrman nuclear grade 2 of4 Tumor size greatest dimension):7.9 cm in greatest dimension Extent of tumor invasion: Capsular invasion/perirenal adipose tissue: Negative Gerotas fascia: Negative Renal vein: Negative Ureter: Negative see comment) Lymphovascular space invasion: Not identified Histologic assessment of surgical margins: Perirenal adipose tissue: Negative Gerota s fascia: Negative Renal vein: Negative Renal artery: Negative Ureter: Negative Other significant findings: -Non-neoplastic kidney with severe atrophy and cystic change AJcc Staging:pT2a pNx
+
+--- Page 2 ---
+This staging information is based on information available at the time of this report, and is subject to change pending clinical review and additional information. Comment: Sections of ureter show free floating fragments of renal cell carcinoma within the ureteral lumen without invasion or involvement of the ureteral wall. Clinical History: The is with a left renal mass. Gross Description: Specimen A received is one appropriately labeled container. The specimen label states "left nephroureterectomy. Specimen fixation: formalin Type of specimen: nephroureterectomyleft Size and weight of specimen:180 g,15 x9 x6 cm overall Orientation: The external surfaces of the specimen are inked blue.A 12.2 cm length of ureter is attached to the specimen. Presence/absence of adrenal gland: absent Tumor description/site: Grossly the tumor encompasses the entire kidney, and there is no normal-appearing kidney parenchyma identified. The cut surface of the tumor demonstrates a soft, necrotic, fleshy, and friable texture with a white-tan coloration. As the specimen is serially sectioned, plugs of tumor fall out of cavities in what appears to be a dilated renal pelvis. Tumorsize7.9x6.5x5.1cm Presence/absence of multicentricity: absent Confinement/non-confinement to the kidney: confined Extent of invasion: Perirenal adipose tissue:Notinvolved by tumor Gerotas fascia: Not involved by tumor
+
+--- Page 3 ---
+Renal vein: Not involved by tumor Ureter: Not involved by tumor Other organs: not applicable Surgical margins: Perirenal adipose tissue: negative Renal vein: negative Renal artery: negative Ureter: negative Description ofkidney away from tumor: There are multiple cysts (l.6 cm greatest dimension) with smooth linings located at the inferior pole of the kidney. The cysts are productive of thin, straw-colored fluid. Lymph nodes (hilar): no lymph nodes are identified Other significant findings: The ureter is serially sectioned and reveals the lumen of the proximal aspect to be filled with a maroon-red sludge-like material. Otherwise, the ureter is grossly unremarkable. Tissue submitted for special investigations: Representative tumor and representative normal renal parenchyma is submitted to tissue procurement. Digital photograph taken: none Block Summary: Al - vein and artery margins A2-tumor at blue ink A3 -tumorathilum A4 - tumor undermining renal pelvis A5 - representative cysts at inferior pole of kidney A6 - ?residual normal renal parenchyma A7 - tumor and ?normal appearing renal parenchyma A8 - additional representative tumor A9 - additional representative tumor (two separate pieces) Al0 - representative cross sections of proximal half ureter Al1 -ureteral margin
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index 0000000000000000000000000000000000000000..d2033ce67f5865e520659ed78ddc982c0d0af5eb
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+
+--- Page 1 ---
+UUID:AABC7EE2-E6E5-43A2-A4A1-B76E6C8BBC18 TCGA-UZ-A9PO-01A-PR Redacted SURGICAL PATHOLOGY REPORT * AmenDeD * Patient Name: Accession #: Med. Rec.#: Visit #: Service Dat DOB: Sex: Male Received: Soc. Sec. #: Location:  Client: Physician(s): FInal Pathologic Diagnosis Right kidney, partial nephrectomy: Oncocytic papillary renal cell carcinoma, type 1,. Fuhrman grade 1-2, margins free of tumor; see comment.. Comment: Kidney Tumor Synoptic Comment -Histologic type: Renal cell carcinoma, oncocytic papillary, type 1.. -Grade: Fuhrman grading for RCC: 1-2; 1: Small nuclei, minute or absent nucleoli. ICD-0.3 2: Slightly irregular, larger nuclei with nucleoli visible at 400x. Maximum tumor diameter: 3 cm. Areeneni yelpilorey NneIe -Site within kidney: Posterior-superior. 8Q60]3 -Renal pelvis: Not present. -Ureter: Not present. Site RYedrey N6g -Renal sinus: Not present.. 064.9 -Hilar renal veins: Not present.. Intrarenal veins and lymphatics: Normal, no tumor..  3|80|14 -Adrenal gland: Not present. -Capsule/perirenal fat: Tumor does not penetrate capsule. Hilar lymph nodes (number positive/number of nodes): None identified.. Resection margins: Negative. -Proximity to nearest margin: 0.2 cm to the capsular margin. -Stage: pTlaNXMX. -Additional comments: Oncocytic papillary renal cell carcinoma is a distinct variant among the papillary renal cell carcinomas (see reference below). The papillary architecture and presence of necrosis argue. against a diagnosis of oncocytoma. Dr  has reviewed the case and concurs with the diagnosis. Both the specimen and requisition are labeled "left kidney mass" while data in. dictated note by  Page 1 of 2
+
+--- Page 2 ---
+Pand operative note) indicate that the mass is located in the right kidney. Dr.. was contacted and verified that the specimen is from the right kidney. Reference: Lefevre M, Couturier J, Sibony M, Bazille C, Boyer K, Callard P, Vieillefond A, Allory Y. Adult papillary renal. tumor with oncocytic cells: clinicopathologic, immunohistochemical, and cytogenetic features of 10 cases. Am J. Surg Pathol. 2005 Dec;29(12):1576-81. This report has been amended to correctly identify the operated kidney as *right*.. Specimen(s) Received A:Left kidney mass Clinical History. The patient is a. year-old man. No further history is provided. Review of indicates the patient has an enhancing right posterior-superior renal mass.. Gross Descriptiond The specimen is received fresh in one part, labeled with the patient's name, medical record number and "left kidney mass." It consists of a section of kidney with attached perirenal fat. The entire specimen. measures 6 x 4 x 3.5 cm. The kidney measures 3 x 3 x 2.5 cm. The kidney resection margin is inked blue,. while the radial margin is inked in black. Sectioning reveals a 3-cm red-yellow lesion in the kidney that approaches to within O.2 cm of the renal capsule, but appears to be entirely encapsulated. This tumor also. extends to within O.4 cm of the biue inked margin. A sample of the tumor is submitted for tumor banking.. Representative sections are submitted in cassettes Al-A4. Diagnosis based on gross and microscopic examinations. Final diagnosis made by attending pathologist following review of all pathology slides.. Pathotogy Resident. Electronicaily signed out on (d h 1/b/14 Page 2 of 2
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diff --git a/output/text/ab7ddd72-37b8-45a5-b8fc-7c6addcfa6a6.txt b/output/text/ab7ddd72-37b8-45a5-b8fc-7c6addcfa6a6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f9530c2b7fe3dd23b6db1a8e47ecb6306065a355
--- /dev/null
+++ b/output/text/ab7ddd72-37b8-45a5-b8fc-7c6addcfa6a6.txt
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+
+--- Page 1 ---
+Carun ome, juct,mfiHtnatvg and 1cbulav 852x1 Cs0.9 Surgic: UUID:889D6E80-A656-49FA-9DFA-1674E33877F6 TCGA-B6-A0RP-01A-PR Redacted Surg Path CLINICAL HISTORY: Biopsy of right and left breast in On the right side we only did a limited dissection of nodes.. GROSS EXAMINATION: A.,rLeft breast and axilla", fresh. Received is a left modified radial tail. The skin ellipse measures 21 x 10.5 cm. The nipple and areola are located centrally on this. The nipple is retracted. There is a partially healed incision site running circumferentially around the lateral areola from approximately the 1:00 to the 4:00 position which measures 4 cm in length. No additional skin lesions are noted. The underlying breast tissue measures 23 x 13 x 7 cm. Margins are inked blue, and the specimen is serially sectioned. There is a large, grossly apparent tumor in the upper outer quadrant which is measures 2.6 x 2.5 x 1.5 cm.  This tumor grossly extends to within 1.3 cm of the deep surgical margin. This lesion will be designated as *lesion #1." Further sectioning demonstrates a healing biopsy site subjacent to the areola, located at the junction between upper and lower outer quadrants. In this region, the biopsy cavity measures up to 2.3 x 0.3 x 0.2 cm. At the nipple, in the region of retraction, there is firm, white tumor; there is also diffuse firmness about the biopsy cavity suspicious for residual tumor in an area measuring 2.8 cm in greatest dimension. This measures 4.0 cm from the deep margin of resection and is distinctly separate from the previously described lesion. The second area of abnormality shall be designated as "lesion #2." Further sectioning in the left lower outer quadrant reveals a third nodule; this is firm, gray, infiltrates into surrounding fibrous parenchyma, and measures 1.0 cm in greatest dimension. It measures 3.5 cm from the deep surgical margin, and is distinctly separate from the other two nodules. shall be designated as "lesion #3."  This Sections through the remainder of the breast shows firm fibrous breast parenchyma but no additional discrete masses. Sections are submitted as follows: Al- nipple and areola and incision site with grossly apparent tumor (lesion #2). A2-A4- sections of biopsy site with surrounding induration (lesion #2). A5- tangential sections of margin deep to lesion #2.. A6-A8- sections through lesion #1 (closest approach of tumor to superior margin in A8.). A9- tumor #1 approaching superior margin, and tangential sections of deep margin. Al0- fibrous parenchyma between tumor number one and two, grossly free of tumor. All- random sections, upper inner quadrant. A12- random sections, upper outer quadrant. Al3-14- small tumor in lower outer quadrant (lesion #3).. A15- additional sections, lower outer quadrant. A16- lower inner quadrant.. The attached axillary tail measures 12 x 6 x 3 cm. Within this, multiple lymph nodes are identified; at least two nodes appear grossly involved with tumor. 1 of 4
+
+--- Page 2 ---
+A17- single 3 cm lymph node, grossly positive (a portion of this lymph node is. submitted to Tissue Bank).. A18-- multiple lower level axillary lymph node candidates.. A19- single lower level axillary lymph node, bisected. A20- single large mid axillary lymph node, bisected.. A21- multiple mid axillary lymph nodes. A22- distal axillary lymph nodes. Note: A portion of tumor number one, skin, and grossly positive lymph node tissue have all been submitted to the Tissue Bank. Per the surgeon, ER/PR analyses have already been performed, and therefore no additional tissue is banked for receptor analysis.. B. rRight breast and axillary contents", fresh. Received is a right mastectomy specimen with a 15 x 8.5 cm ellipse of tan skin. The nipple and areola are. located relatively centrally and somewhat inferiorly; there is no nipple retraction. There is a healing peri-areolar incision site running from approximately the 10:00 to 1:00 position in the upper outer and portion of brown skin nodule measuring 1.3 x 1.3 x 0.2 cm located at the lateral tip of the skin ellipse, which is grossly consistent with a seborrheic keratosis.. other skin lesions are identified. No The underlying breast tissue measures 20 x 11 x 3 cm. Sectioning through the breast parenchyma after margins are inked reveals dense fibrous parenchyma. In the upper breast, at the junction of upper inner and upper outer quadrant, there is a healing biopsy cavity which measures 3.5 x 3 x 2 cm; this is surrounded by fat necrosis and firm tissue and has a hemorrhagic rim with no definite gross residual tumor. The biopsy changes extend to within 2.5 cm of the deep margin.  No masses or other abnormalities are identified. Block Summary: B1-- sections of seborrheic keratosis. B2- nipple and areola, and skin with healing biopsy scar.. B3- B5- sections of wall of biopsy cavity.. B6- margins to deep to biopsy site (tangential).. B7- random sections, upper outer quadrant. B8- random sections, upper inner quadrant. B9- random sections, lower inner quadrant. B10-random sections, lower outer quadrant.. There is no definite axillary tail attached to the specimen. There is a strip of fibrofatty tissue measuring 6 x 2 x 1 cm, in which no lymph nodes are grossly identified. Sections of fibrofatty axillary tissue are submitted in Blocks B11 and B12. MICROSCOPIC EXAMINATION:S Sectoions of lesion #l of the left breast show infiltrating duct carcinoma. Tumor cells are arranged as tubules and in nests, and infiltrate into surrounding fibrous stroma and fat with accompanying desmoplastic response. There is a moderate degree of nuclear pleomorphism. Focally, comedo and cribriform intraductal carcinoma is present in association with this mass (A7), although this intraductal component is minor. Sections of lesion #2 of the left breast show tumor which predominantly has linear "indian file" rows. Nuclei are relatively small and bland. There is extensive infiltration of areolar smooth muscle and fibrous parenchyma, as. well as extensive perineural invasion. In several small foci, small tubles of neoplastic cells are present.  There are several foci of associated intraductal carcinoma with cancerization of lobules/ lobular carcinoma in situ. Sections of lesion #3 of the left breast show a lesion with a papillary appearance; in most areas, this appears to be an intraductal process, although 2 of 4
+
+--- Page 3 ---
+in one area an associated component of invasive duct carcinoma is seen. Papillomas are present in adjacent breast tissue.. DIAGNOSIS: A. "LEFT BREAST AND AXILLA": LEFT BREAST WITH THREE SEPARATE FOCI OF BREAST CARCINOMA. CARCINOMA NUMBER ONE(A1-A3) : INFILTRATING DUCT CARCINOMA (UPPER OUTER QUADRANT), 2.6 X 2.5 X 1.5 CM, N.S.A.B.P. NUCLEAR GRADE MODERATELY DIFFERENTIATED, HISTOLOGIC GRADE 2/3. INTRADUCTAL CARCINOMA COMEDO AND CRIBRIFORM TYPES, COMPRISES LESS THAN 5% OF THE TUMOR. VASCULAR INVASION IS PRESENT. DEEP MARGIN FREE OF CARCINOMA. CARCINOMA NUMBER TWO (A6-8): TUBULOLOBUAR CARCINOMA WITH PREDOMINANTLY LOBULAR.FEATURES (SUBAREOLAR REGION AT JUNCTION BETWEEN UPPER AND LOWER OUTER QUADRANTS),  IN REGION OF HEALING BIOPSY SITE, 2.8 CM IN GREATEST DIMENSION. INTRADUCTAL CARCINOMA/ LOBULAR CARCINOMA IN SITU IS PRESENT, COMPRISING LESS THAN 18 OF THE TUMOR. TUMOR EXTENDS INTO THE LARGE DUCTS AND SOFT TISSUE OF THE NIPPLE. DEFINITIVE VASCULAR INVASION IS NOT PRESENT. DEEP MARGIN FREE OF CARCINOMA. CARCINOMA NUMBER THREE (A13-A14): INFILTRATING DUCT CARCINOMA ARISING IN A REGION OF PAPILLARY INTRADUCTAL CARCINOMA (LOWER OUTER QUADRANT), 1.0 CM IN GREATEST DIMENSION, N.S.A.B.P. NUCLEAR GRADE MODERATELY DIFFERENTIATED, HISTOLOGIC GRADE 2/3. DEEP MARGIN FREE OF TUMOR. NO DEFINITE VASCULAR INVASION IDENTIFIED. REMAINDER OF BREAST WITH MULTIFOCAL INTRADUCTAL CARCINOMA (SOLID AND CRIBRIFORM TYPES) WITH CANCERIZATION OF LOBULES, LOBULAR CARCINOMA IN SITUE, FLORID EPITHELIAL HYPERPLASIA OF USUAL TYPE, INTRADUCTAL PAPILLOMA (A13), APOCRINE METAPLASIA, ADENOSIS, DUCT ECTASIA, AND MICROCYSTS. TWO OF FIFTEEN LEFT AXILLARY LYMPH NODES INVOLVED WITH METASTATIC CARCINOMA (2/15). (TUBULOLOBULAR PATTERN) SKIN WITH HEALING WOUND AND NO EVIDENCE OF MALIGNANCY. B. "RIGHT BREAST AND AXILLARY CONTENTS": BREAST WITH HEALING BIOPSY SITE WITH FAT NECROSIS, FOREIGN BODY REACTION, AND GRANULATION TISSUE. MULTIFOCAL INTRADUCTAL CARCINOMA, SOLID TYPE, WITH CANCERIZATION OF LOBULES, INCLUDING REGIONS AROUND BIOPSY CAVITY (B5) AND IN LOWER OUTER QUADRANT (B1O). FOCAL INFILTRATING DUCT CARCINOMA (B2), N.S.A.B.P. NUCLEAR GRADE WELL DIFFERENTIATED, HISTOLOGIC GRADE 1/3. DEEP MARGIN FREE OF CARCINOMA. SKIN WITH HEALING WOUND, SEBORRHEIC KERATOSIS, EPIDERMAL INCLUSION CYST, AND NO EVIDENCE OF MALIGNANCY. REMAINDER OF BREAST WITH FLORID EPITHELIAL HYPERPLASIA OF USUAL TYPE, ADENOSIS, AND APOCRINE METAPLASIA. NO LYMPH NODES IDENTIFIED IN LIMITED AXILLARY DISSECTION. 3 of 4
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diff --git a/output/text/ab8a6f6b-f896-4dcd-8a9c-dba91e049b90.txt b/output/text/ab8a6f6b-f896-4dcd-8a9c-dba91e049b90.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b1dc04c771c170611314300722ea18da0e0c1d10
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+*** Diagnosis / Diagnoses: *** Right hemicolectomy specimen with tumor-free resection margins, with two tubular. colonic mucosal membrane adenomas with mild dysplasia (synonym: low-grade intra- epithelial neoplasia) and under inclusion of an ulcerated, moderately differentiated adenocarcinoma of the ascending colon with infiltration of the perimuscular fatty tissue and without regional lymph node metastases (G2, pT3 pN0 0/36 L1 V0 R0).
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diff --git a/output/text/ab8b4a0f-f1d3-48c3-9fbb-8d7ff27d0684.txt b/output/text/ab8b4a0f-f1d3-48c3-9fbb-8d7ff27d0684.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5ed3474315b75fe486b24aec073428fd1d1a493e
--- /dev/null
+++ b/output/text/ab8b4a0f-f1d3-48c3-9fbb-8d7ff27d0684.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Operative Procedure: DA Vinci right radical nephrectomy Specimen Received: A:  Interaortocaval Iymph nodes B:  Right paracaval lymph node C: Right kidney. Final Pathologic Diagnosis: A. "Interaortocaval lymph nodes," biopsy: Four lymph nodes negative for malignancy (0/4) B. "Right paracaval lymph nodes," excision: One of eleven lymph nodes positive for metastasis measuring 0.7 cm (1/11 slide B4) Positive for extranodal extension. C. Kidney, right, nephrectomy: Tumor histologic type: Poorly differentiated carcinoma, favor type Il papillary renal cell carcinoma (see NOTE) Tumor size: 6.5 cm Other dimensions: 6.2 x 5 cm Macroscopic extent of tumor: Macroscopic extension into perinephric fat, renal sinus fat, and a renal vein Focality: Unifocal Fuhrman grade: 3 of 4 Perinephric fat invasion: Yes Renal sinus invasion: Yes Renal vein involvement: Yes Adrenal gland present: No Cancer at resection margin: No Pathologic findings in nonneoplastic kidney: No Hilar lymph nodes present: No Pathologic stage pT3 pN1 pM(not applicable) The examination of this case material and the preparation of this report were performed by the staff pathologist. Note: The tumor is composed of a variable morphology including areas of typical papillary renal cell carcinoma, and areas resembling collecting duct, carcinoma, medullary carcinoma, and sarcomatoid areas. However, TFE3 were negative. The  majority of the H/E slides demonstrate a papillary architecture but there are many areas that are difficult to classify. Numerous immunohistochemical stains
+
+--- Page 2 ---
+and additional sections help support the above diagnosis but the tumor may better be represented as unclassified type. The translocation carcinoma is virtually ruled out with the negative HMB45 and Melan-A. The tumor is variable. positive for cytokeratin 34betaE12 and CK7 in the more papillary areas with. diffuse positivity with cytokeratin AE1/AE3. There is also a nonspecific perinuclear dote like staining with the p63. There does not appear to be any mucin. The overall staining with positive CK7, PAX-2, AMACR, and focal CD10 support a papillary renal cell carcinoma but does not totally rule out a collecting duct carcinoma/medullary carcinoma. The patient does not have a history of sickle cell trait and the morphology is not convincing of medullary carcinoma. The possibility of an invasive urothelial carcinoma is unlikely because extensive sampling failed to demonstrate malignant TCC or CIS component. A TTF-1 immunostain was also negative. The above stains were performed with adequate controls. Gross Description: The specimen is received in formalin three parts labeled with the patient's name. Part A labeled"interaortocaval lymph nodes" and consists of a portion of irregular, ragged, gray-yellow, lobulated fat, which has dimensions of 3.0 x 2.6 x 0.8 cm. An exhaustive search of the fat to include the use of palpation and chemical clearing agent reveals four probable lymph nodes that range from 0.4 to 1.4 cm in greatest dimension. The lymph nodes are entirely submitted as labeled: A1 one bisected lymph node;. A2  three lymph nodes submitted in toto. Part B labeled "right paracaval lymph nodes" consists of a portion of irregular, ragged, gray-yellow lobulated fat, which has dimensions of 8.0 x 4.0 x 1.5 cm. An exhaustive search of the fat to include the use of palpation and a chemical. clearing agent reveals eleven probable lymph nodes that range from 0.4 to 2.4 cm in greatest dimension. The lymph nodes are entirely submitted as labeled: B1-2 ten lymph nodes submitted in toto; B3-4 one bisected lymph node.. Part C labeled "right kidney.". Specimen components and dimensions: The specimen consists of a right kidney received with a moderate amount of attached perinephric fat. The specimen has dimensions of 15.6 x 7.4 x 6.6 cm. The renal parenchyma has dimensions of 10.4 x 6.2 x 5.4 cm. An adrenal gland is not present. There is an attached segment of ureter, which has a length of 7.9 cm and a diameter of approximately 0.5 cm throughout. The vessels are identified and ligated close to the kidney. Some tissue has been submitted fresh to the. Size, appearance, and location of tumor: The central kidney is remarkable for a gray-white, indurated, fibrous mass with lobulated edges, which has dimensions
+
+--- Page 3 ---
+of 6.5 x 6.2 x 5.0 cm. Renal capsule/renal sinus: At the hilum, this mass extends to the capsule. It is possible there are some foci where the mass traverses the capsule and superficially invades the hilar fat. The renal sinus fat is grossly invaded. The. mass extends through the capsule. into the perinephric fat and to within 1 mm of the posterior inked soft tissue edge.. Renal vein: The renal vein is grossly invaded and extends to within 0.3 cm of the renal vein margin. Lymph nodes (size, number, & location): An exhaustive search of the hilar fat to include the use of palpation and a chemical clearing agent reveals no grossly identifiable lymph nodes. Other findings: The renal parenchyma is red-brown with a well defined corticomedullary border and a cortical thickness of approximately 0.6 cm throughout. The urothelium is gray-white, smooth and glistening with some of the pelvis and calyces markedly compressed by this mass. It is unclear as to whether the mass arises from the pelvic urothelium or the surrounding parenchyma. Blocks submitted:. C1  ureter margin en face; C2  vein and artery margin en face; C3 proximal ureter;. C4 mid ureter; C5 distal ureter; C6-8 mass to capsule and inked external surface at the hilum;. C9-10 mass to capsule and inked external surface at the posterior. aspect; C11 mass to intraparenchymal renal vein;. C12-13  mass to renal sinus fat; C14  normal most parenchyma; C15  mass to pelvis.. Additional representative sections are submitted in cassettes C16-25.. Also, gross images have been taken of the specimen. Due to the nature of the tissue procurement performed on the specimen, prosecting was extremely challenging. Microscopic Description: The final diagnosis of each specimen incorporates the microscopic examination findings. END OF REPORT Taken: Gender: F
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diff --git a/output/text/ababcaaf-fcc2-40b5-9455-34f31f1328ee.txt b/output/text/ababcaaf-fcc2-40b5-9455-34f31f1328ee.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4f6a2c26bed47effcd6e2e6eab49a0f0eda6ab0d
--- /dev/null
+++ b/output/text/ababcaaf-fcc2-40b5-9455-34f31f1328ee.txt
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+
+--- Page 1 ---
+Ics-0-3 Carciomn, infiftnaHug ouctd, nos 8500/3 Pan Sih: 3ust,wtnul C50.1 1/21/11 potim cQCF S;hr Ersst,N0s c50.9 Diagnosis: 1. Ablated breast sample with a highly differentiated invasive carcinoma. (tumor diameter: 9 cm) with circumscribed intraductal components. Tumor-free dorsal resection margin. In conclusion, this is a highly differentiated invasive ductal carcinoma.. Tumor classification: NOS, G I, pT3N0L0V0R0 UUID:AF0A2220-DEEC-44C8-B15C-B6442D587517 Redacted
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diff --git a/output/text/abb68cde-eaee-43f4-a4ca-665b11bd68a7.txt b/output/text/abb68cde-eaee-43f4-a4ca-665b11bd68a7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e0f678621fd36f7ac7ab162e31675a9b77450496
--- /dev/null
+++ b/output/text/abb68cde-eaee-43f4-a4ca-665b11bd68a7.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+CGA-A6-2672 SPECIMEN Right colon CLINICAL NOTES PRE-OP DIAGNOSIS: Colon cancer GROSS DESCRIPTION Received fresh, subsequently fixed in formalin labelled "right colon" which is partially covered with pink-tan smooth glistening serosa and yellow lobular fat. The specimen shows a 6.5 x 0.7 cm appendix and the specimen is predominately covered with abundant yellow lobular fat. The specimen is opened and has a 6.5 cm portion of small bowel and 26 cm of cecum and colon. The specimen shows a large ectophytic mass which is 7.0 x 5.5 x 1.2 cm. This is located 6.5 cm from the distal margin. The cut surface of the tumor shows gross invasion into the muscularis propria, however, showing possible invasion into the fat. This comes within 6.5 cm of the radial margin. No other discrete gross lesions are identified. The average circumference of the small bowel is 4.0 cm and the average circumference of the cecum and colon is 7.0 cm. Representative sections of the specimen are submitted as follows: BLock summARy: 1 - representative luminal margins and ileocecal valve; 2 - representative section of appendix with proximal end inked; 3~5 - representative sections of tumor to normal and fat; 6 radial margin with lymph node at radial margin; 7-8 - nine possible lymph nodes; 9 - six possible lymph nodes; 10 - three possible 1ymph nodes; 11 - three possible lymph nodes; 12 - one possible lymph node from near radial margin; 13-14 - one lymph node bisected. RS-14.
+
+--- Page 2 ---
+MICROSCOPIC DESCRIPTION Histologic type: Adenocarcinoma.. Histologic grade: Moderately-differentiated. Primary tumor: pT3 (carcinoma penetrates through the muscularis propria, into the subserosal fat).. Proximal margin: Negative. Distal margin: Negative. Circumferential (radial) margin:. Negative.. Vascular invasion: Probable Regional lymph nodes. pN): One of twenty-nine lymph nodes with. metastatic carcinoma Non-lymph node pericolonic tumor: Not identified. Other findings: Appendix with serosal fat necrosis and otherwise unremarkable; small bowel unremarkable. 5 DIAGNOSIS Right Colon with appendix, small bowel, right hemicolectomy: Adenocarcinoma, moderately differentiated, with invasion through the muscularis propria, into the subserosal fat (pT3). Margins of excision negative.. One of twenty-nine lymph nodes with metastatic carcinoma
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diff --git a/output/text/abe1c610-fc4c-401b-b1ab-b2be2367bde2.txt b/output/text/abe1c610-fc4c-401b-b1ab-b2be2367bde2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..11a2dac08730db3609b3421ed7b6fd49495c3ae9
--- /dev/null
+++ b/output/text/abe1c610-fc4c-401b-b1ab-b2be2367bde2.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+/c-0-3 UUID:E9231B33-E1CE-4396-9F9E-03DBF049919A Redacted Carcinomn inflfratry duct Nos 85oo/3 TCGA-AR-A0TT-01A-PR Site: bresat, No5C50.9 Breast, right, wide local excision: Infiltrating ductal carcinoma, Nottingham grade III (of Il) [tubules 3/3, nuclei 3/3, mitoses 2/3; Nottingham score 8/9], forming a mass (2.3 x 1.9 x 1.8 cm) [AJCC pT2]. Ductal carcinoma in situ is absent. Angiolymphatic invasion is absent. The non-neoplastic breast parenchyma shows nonproliferative fibrocystic changes. All surgical margins are negative for tumor (minimum tumor free margin, 0.5 cm, deep margin).. Lymph nodes, right axillary sentinel Nos. 1A, 1B, 1C, 2A, 2B, and 2C, excision: Multiple (3 of 6) right axillary sentinel lymph nodes, all without blue dye, are positive for for metastatic carcinoma. Lymph nodes, right axillary, dissection: Multiple (2 of 13) right axillary lymph nodes are positive for metastatic carcinoma [AJCC pN2]. Extranodal extension is present. Her-2/NEU has been ordered on paraffin-embedded tissue.
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diff --git a/output/text/abf71b95-d242-4c4d-83ad-c06dffbe65ca.txt b/output/text/abf71b95-d242-4c4d-83ad-c06dffbe65ca.txt
new file mode 100644
index 0000000000000000000000000000000000000000..be70bc58c89b618a6dab81cddd678eed0c312b8d
--- /dev/null
+++ b/output/text/abf71b95-d242-4c4d-83ad-c06dffbe65ca.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Patient Results UUID: 3CCFB076-52BE-4A5D-9E49-65516AA9C349 Requested By: TCGA-FF-A7CQ-01A-PR Redacted Histopathology Report Biopsy No Received Date/Time Final Final  Reporting Information Date/Time :  Final Histopathologist : Laboratory : Consultant-In-Charge Final Submitting Physician NOT STATED Final  Histopathology Report Final DIAGNOSIS RIGHT CERVICAL LYMPH NODE; EXCISION : DIFFUSE LARGE B-CELL LYMPHOMA. GROSS DESCRIPTION Received in formalin is a specimen labelled with patient's data and designated "lymph node biopsy". It consists of 3 pieces of brownish tissue measuring 1.2 x 1 x 0.4cm, submitted entirely. (Al; no reserve) A separate piece of tissue received fresh measuring 0.9 x 0.5 x 0.5m is snap-frozen for storage. MICROSCOPIC DESCRIPTION Histology shows a fragmented lymph node with architectural effacement by a diffuse, patternless proliferation of lymphomatous large cells with a centroblastic nucleolar disposition, scattered mitoses and foci of plasmacytoid proliferation is strongly positive for pan-B cell marker cd20 and coexpresses postgerminal centre-associated transcription factor Mum.l, but not cD138, which decorates only small numbers of scattered mature plasma cells. The lymphomatous accounted for by physiological expression in admixed, cD3-positive, reactive, small T-lymphocytes, albeit focally plentiful, while being negative for germinal centre-associated antigen coio, which highlights only occasional stromal cells and polymorphs, in keeping with an "activated B-cell" phenotypic profile, thereby excluding Burkitt lymphoma in conjunction with a celi proliferation immunolabelling, as well as a lymphoblastic neoplasm in conjunction with negativity for terminal deoxynucleotidyl transferase, which highlights only a few, scattered, circulating haematogones. Immunostaining for Cyclin Dl is negative within the lymphoid proliferation, highlighting only physiological expression in scattered histiocytic and activated endothelial nuclei, excluding a transformed mantle cell lymphoma. Only a few overrun or disrupted cD2l-immunoreactive follicular dendritic meshworks are discerned, providing no support for an origin from a transformed follicular lymphoma. Pathologist : IQDO-3 Mc J qb8o/3 Site Curvicol lynpr noelp CZ7.0 Jt) 8(2b|13 Printed from: End of Report Page: ! of 1
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diff --git a/output/text/ac0ed0b7-160d-464a-8e28-f70d08631e90.txt b/output/text/ac0ed0b7-160d-464a-8e28-f70d08631e90.txt
new file mode 100644
index 0000000000000000000000000000000000000000..92146217e059946d226e08769d248faccd474390
--- /dev/null
+++ b/output/text/ac0ed0b7-160d-464a-8e28-f70d08631e90.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID: B1683335-4928-471B-AEFE-2350EA558BFC Redacted TCGA-D8-A3Z5-01A-PR page 1/1 Department of Cancer Pathology Examination: Histopathological examination Internal invoice No. Value of diagnostic procedure. Examination No.: Patient: xXx xXX Age: Gender: Material: 1. Total organ resection - right breast and axillary lymph nodes ic d-o-3 Unit in charge: : 8s2013 Physician in charge: Sik: b<cgsf,N0S c50.9 Material collected or Material received or Expected time of examination: up to 8 working days QJ4hz e0 Clinical diagnosis: Cancer of the right breast. Examination performed on:. Macroscopic description: Right breast, sized 27.8 x 17.2 x 6.8 cm, removed along with axillary tissues sized 13 x 9 x 4 cm and a skin flap of 21.8 x 10.3 cm. Weight 940 g. Tumour sized 4.2 x 2.4 x 1.4 cm found on the boundary of outer quadrants, placed 2.2 cm from the outer boundary, 1.6 cm from the base and 2.6 cm from the skin. Lymph nodes of 1 cm in length. Microscopic description: Carcinoma lobulare invasivum (classical type) - NHG1 (3 + 1 + 1/0 mitoses/ 10 HPF - visual area 0,55 mm). Infiltratio carcinomatosa mamillae. Lesions in situ of the type: carcinoma lobulare in situ (LCis). Glandular tissue showing parenchyma atrophy. AxILLAR LYMPH NODES: Metastases carcinomatosae in lymphonodis (No xIx/xxI). Infiltratio telae perinodalis. Histopathological Diagnosis. Carcinoma lobulare invasivum mammae dextrae. Lubular invasive carcinoma of the right breast  Metastases carcinomatosae in lymphonodis axillae (No Xix/xxI) (NHG1, pT2, pN3a). Cancer metastases in the axillary lymph nodes No xix/xxI. Compliance validated by: Examination performed on Result of immunohistochemical examination Estrogen receptors found in 75% of neoplastic cell nuclei. Progesterone receptors found in 75% of neoplastic cell nuclei. HER2 protein stained with by ). Negative reaction in invasive cancerous cells ( Score =1+) Compliance validated by: CONTACT YOUR DOCTOR WITH THIS REPORT!
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index 0000000000000000000000000000000000000000..fbade49550394b35235be198853391f2955ae9b2
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+C. i,qit+ts; (wct s i.wviir Sin: brust,nos c50.9 page 1 / 2 Department of Cancer Pathologye Examination: Histopathological examination Examination No.: ' Patient  PESEL: Age: Gender: F Material: Multiple organ resection -- right breast. Unit in charge  Physician in charge: Material collected on Material received on: Expected time of examination: up to 8 working days Clinical diagnosis: Cancer of the right breast.  Examination performed on: Macroscopic description: Right breast, sized 18.3 x 18.8 x 4.2 cm, removed without axillary tissues and with a skin flap of 14.6 x 7.1 cm. Weight 580 g.  Tumour sized 1.6 x 1.2 x 1.8 cm on the boundary of outer quadrants, placed 5.2 cm from the outer edge, 1.2 cm from the base and 0.8 cm from the skin. Status after core needie biopsy (test No. Microscopic description: Carcinoma ductale - NHG2 (3 + 2+1:2 mitoses/ 10 HPF, visual area diameter 0.55 mm),  papilloma intraductale mamillae.. Glandular tissue showing parenchyma atrophy. Examination result: Ancluding test No. anc Carcinoma ductale invasivum mammae dextrae. Metastases carcinomatosae in lymphonodo axillae (No t/VIl). I hv:  Examination performed or...  Results of immunohistochemical examination: Estrogen receptors found in 75% of neoplastic cell nuclei. Progesterone receptors found in 10% of neoplastic cell nuclei.. HER2 protein stained with HercepTest'M by DAKO. Score = 2+, verification by the FiSH method recommended. UUID:1D26CB97-536A-4D10-A593-73C3A846BB13 TCGA-D8-A145-01A-PR Compliance validated by: Redacted
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diff --git a/output/text/ac471951-9927-4d0e-b72d-ef96f5746903.txt b/output/text/ac471951-9927-4d0e-b72d-ef96f5746903.txt
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+Jcs-0-3 Carcmioma, mnfiltrutiay ouctl, Nos85oo/3 SH: Bust, NOS c50.9 Diagnosis 1. Left-sided ablated breast tissue with a poorly differentiated invasive ductal breast carcinoma measuring a maximum of 6 cm with focal invasion of the lymph vessels, extension to the base of the nipple and the pectoral muscle and excision extending just into the healthy tissue in the basal epidermis. No pagetoid tumor propagation or skin infiltration.. Tumor classification: M-8500/3, G 3, pT3, pN2a (5/13), pMX, stage III A. R0. UUID: BC0E0F93-B183-44E8-B551-EA46382FBCE4 Redacted
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diff --git a/output/text/ac4817b7-ef58-4341-b625-d2becac2e34e.txt b/output/text/ac4817b7-ef58-4341-b625-d2becac2e34e.txt
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index 0000000000000000000000000000000000000000..c57cbae0fe88fcc1c680b1453cb1f547fe8bcc2d
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+Canncmu,mnfiltrufing duct Ncs 850of3 Pell TSS: CQcF Sih: brssf, Nos c50.9 10/25/10 tss: SPECIMENS: UUID:2F35A09A-7EB3-484C-9738-664C8914C116 TCGA-E2-A1B4-01A-PR A. LEFT BREAST WLE NEEDLE LOCALIZATION Redacted B. SLN #1 C. SLN#2 D. SLN #3 E. SLN #4 SPECIMEN(S): A. LEFT BREAST WLE NEEDLE LOCALIZATION B. SLN #1 C. SLN#2 D. SLN #3 E. SLN #4 INTRAOPERATIVE CONSULTATION DIAGNOSIS: A- left breast, WLE gross examination only: 1 cm tumor located 1 cm from the closest/posterior margin. called by Dr. to Dr. it TPB/TPC/TPD/TPE-SLN #1, 2, 3, 4: No tumor cells seen by touch prep. Part D. contains only fat tissue. called by Dr. to Dr. at GROSS DESCRIPTION: A. LEFT BREAST WLE NEEDLE LOCALIZATION Received fresh with accompanying radiogram is an oriented 41 g lumpectomy specimen with. Iocalization needie. The specimen is oriented with a single suture designating anterior, double lateral, triple superior. The specimen measures 5.8 cm from anterior to posterior, 5.2 cm from superior to inferior, and 2.8 cm from medial to lateral. Specimen is inked as follows: inferior-orange, superior-red, lateral-yellow, anterior-blue, medial-green, posterior-black. Specimen is serially sectioned from superior to inferior; there is a firm well-circumscribed white-tan nodule measuring 1 cm located 1 cm from the nearest posterior and anterior margins, 1.8 cm from the lateral margin, 3.1 cm from the medial margin, and greater than 3 cm from the superior and inferior margins. A gross diagnosis is conveyed to O. R. A. portion of the mass is submitted for tissue procurement. Specimen is submitted entirely as follows: A1-A3: superior margin perpendicuiar sections A4: slice 2, medial A5: slice 2, mid A6: slice 2, lateral A7: slice 3, medial A8: slice 3, mid A9: slice 3, lateral A10: slice 4, medial A11: slice 4, mid {lesion} A12: slice 4, latera! A13: slice 5, medial A14-A15: slice 5, mid {lesion} A16: slice 5, lateral A17: slice 6, medial A18: slice 6, mid-anterior {lesion}. A19: slice 6, mid-posterior {lesion}. A20: slice 6, anterior-lateral. A21: slice 6: posterior-lateral A22: slice 7, medial A23: slice 7, mid A24: slice 7, lateral A25-A26: inferior margin, perpendicular sections B. SLN#1 Received fresh is a lymph node measuring 0.7 cm in diameter. One touch prep is performed. The specimen is submitted entirely in cassette B1.. C. SLN #2 Received fresh is one lymph node measuring 0.4 cm in diameter. A touch prep is performed. The specimen is submitted entirely in cassette C1.. D. SLN #3
+
+--- Page 2 ---
+TSS: Received fresh is a piece of fatty tissue measuring 0.5 x 0.3 x 0.3 cm. A touch prep is performed and the specimen is submitted entirely in cassette D1.. E. SLN #4 Received fresh is a lymph node measuring 0.4 cm in diameter. A touch prep is performed the specimen is submitted entirely in cassette E1. DIAGNOSIS: A. BREAST, LEFT, WIDE LOCAL EXCISION: - INVASIVE, DUCTAL CARCINOMA, SBR GRADE 1, MEASURING 1.2-CM - INVASIVE TUMOR PRESENT WITHIN 0.15-CM FROM MEDIAL SURG!CAL RESECTION MARGIN - LOW TO INTERMEDIATE NUCLEAR GRADE, DUCTAL CARCINOMA IN SITU, CRIBRIFORM TYPE - DUCTAL HYPERPLASIA INVOLVING INTRADUCTAL PAPILLOMA - SEE SYNOpTIC REPORTS SEe NOTE. B. LYMPH NODE, SENTINEL #1, BIOPSY: -METASTATIC CARCINOMA TO ONE OF ONE LYMPH NODE (1/1), MEASURING 0.5-MM (MICROMETASTASES) WITH NO EXTRANODAL EXTENSION, SEE NOTE. C. LYMPH NODE, SENTINEL #2, BIOPSY: -METASTATIC CARCINOMA TO ONE OF ONE LYMPH NODE (1/1). MEASURING O.6-MM (MICROMETASTASES) WITH NO EXTRANODAL EXTENSION, SEE NOTe D. LYMPH NODE, SENTINEL #3, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (O/1).E E. LYMPH NODE, SENTINEL #4, BIOPSY: -METASTATIC CARCINOMA TO ONE OF ONE LYMPH NODE (1/1), MEASURING 2.0-MM (MICROMETASTASES) WITH NO EXTRANODAL EXTENSION, SEE NOTE. NOTE: Two foci of intraductal papilloma with usual ductal hyperplasia are identified, one adjacent to the invasive tumor and one at the posterior surgical resection margin. p63 and calponin mark the myoepithelial cell layer in the papilloma. Dr. concurs on this interpretation. Micrometastases are identified in sentinel lymph nodes#1, #2 (AE 1/3 positive) and #4. The largest tumor metastasis measures 2-mm. The touch preparations were reviewed, no tumor cells identified. Therefore, this discrepancy is due to sampling error. SYNOPTIC REPORT - BREAST Specimen Type: Excision Needle Localization: Yes - For mass Laterality:Left Invasive Tumor: Present Multifocality: No WHO CLASSIFICATION Invasive ductal carcinoma, .NOS.. 8500/3 Tumor size: 1.2cm Tumor Site: Upper inner quadrant Margins: Negative" Distance from closest margin:  0.15cm medial Tubular Score: 1 Nuclear Grade: 2 Mitotic Score: 1 Modified Scarff Bloom Richardson Grade: Necrosis: Absent
+
+--- Page 3 ---
+TSS: Vascular/Lymphatic Invasion: None identified Lobular neoplasia: None Lymph nodes: Sentinel lymph node only Lymph node status: Positive 3 / 4 Micrometastases: Yes DCIS present Margins uninvolved by DCIS DCIS Quantity: Estimate 5% DCIS Type: Cribriform DCIS Location: Associated with invasive tumor Nuclear grade: Intermediate Necrosis: Absent Location of CA++: DCIS ER/PR/HER2 Results ER: Positive PR: Positive HER2: Negative Pathological staging (pTN): pT 1c N mi SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimen:  Surgical Excision Block Number: A18 ER: Positive Allred Score: 8 = Proportion Score 5 + Intensity Score 3 PR: Positive Allred Score: 8 = Proportion Score 5 + Intensity Score 3 COMMENT: The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring range from 0 to 8. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2. METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Immunohistochemistry was performed using the mouse anti-human ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) provided by Daka Ilowing the manufacturer s instructions. This assay was not modified. Interpretation of the ER/PR immunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal review of staining performance. SYNOPTIC REPORT - BREAST HER-2 RESULTS Specimen: Surgical Excision Block Number: A18 Interpretation: NEGATIVE Intensity: 1+ % Tumor Staining: 10% Fish Ordered: No METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Her2 analysis was performed using the FDA approved Dako HercepTest (TM) test kit (. C Ising rabbit anti-human HER2. This assay was not modified. External kit-slides.  provided by the manufacturer (cell lines with high, low and negative HER2 protein expression) and in- house known HER2 amplified control tissue were evaluated along with the test tissue. Adequate, well
+
+--- Page 4 ---
+Tss: preserved, clear-cut invasive carcinoma was identified for HER2 evaluation. Interpretation of the HER2 immunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal review nf staining performance. This assay has been validated according to the joint recommendations and guidelines from ASCO and CAP and from the NCCN HER2 testing in breast Cancer Task Force. The Pathology Department takes full responsibility for this test's performance. CLINICAL HISTORY: Core biopsy proven cancer upper inner quadrant left breast PRE-OPERATIVE DIAGNOSIS: Left breast cancer ADDENDUM: ONCOTYPE DX BREAST CANCER ASSAY RESULTS: Recurrence Score: 7 CLiNICAL EXPERIENCE: Patients with a recurrence score of: 7 in the clinical validation study had an average rate of Distant Recurrence at 10 years of 6% ER Score: 11.1Positive PR Score: 8.9 Positive Her2 Score: 9.9 Negative Interpretation: ER Negative < 6.5 Positive >= 6.5 PR  Negative < 5.5 Positive >= 5.5 Her2 Negative <10.7 Positive >=11.5 Equivocal = 10.7 - 11.4 See separate report for further information. Test performed at: Gross Dictation: Pathologist, Microscopic/Diagnostic Dictation: Patholoaist. Final Review: Patholnnist, Final: Pathologist, Addendum: Pathologist, Addendum Final: Pathologist
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+Specimen Received: A:  Right buccal lymph node B:  Right level 3 lymph node C: Right mental nerve D:  Right masseter muscle E: Right buccal mass F:  Right ptyergoid muscle G:  Inferior masseter margin H: Superior masseter margin. I: Lateral masseter margin J: Right lingual blood vessel K: Medial pterygoid L: Right parotid margin M: Medial alveolar N: Right retro trigone (FS) O: Anterior mandible margin P:  New pterygoid margin Q: Lateral parotid R:  Right level 1-4 neck dissection S: Level 1A neck dissection T:  Right maxillary teeth Final Pathologic Diagnosis: Buccal mass, right, excision: Histologic type/grade: Keratinizing squamous cell carcinoma,  moderately to poorly differentiated Tumor size: 6.8 x 5 x 2.3 cm (greatest dimensions) Depth of invasion: 2.3 cm (greatest dimension) Lymph-vascular invasion: Present Perineural invasion: Present Tumor site: Right buccal mucosa Tumor focality: Single focus with metastasis to level Ib lymph node. Margins: Margins uninvolved by invasive carcinoma Distance from closest margin: 0.5 cm Specify margin(s), per orientation: Superior aspect of specimen Margins uninvolved by carcinoma in situ Lymph nodes, extranodal extension: One lymph node positive for metastatic squamous cell carcinoma No extranodal extension
+
+--- Page 2 ---
+Pathologic Staging (pTNM): TNM descriptors: None known Primary tumor (pT): pT4a Regional lymph nodes (pN):  pN1 Number examined: 43 (includes nodes from parts A, B, Q, R, and S.) Number involved: 1 Size of the largest positive lymph node: 2.4 cm (greatest dimension) Distant metastasis (pM):  pM-N/A Additional pathologic findings:  None Specimen: Buccal mucosa, soft tissue along with skin with vermillion component. Received: In formalin Procedure: Resection of buccal mass with right neck dissection Specimen size: 12 x 7.5 x 7 cm (greatest dimensions) Specimen laterality: Right A. Lymph node, right buccal, biopsy for frozen section (FSA): One lymph node, negative for malignancy (0/1). Frozen section diagnosis confirmed. B. Lymph node, right level 3, biopsy: One lymph node, negative for malignancy (0/1). C. Mental nerve, right, biopsy for frozen section Negative for malignancy. Frozen section diagnosis confirmed D. Masseter muscle, right, biopsy for frozen section Negative for malignancy. Frozen section diagnosis confirmed E. Buccal mass, right, resection: Poorly differentiated squamous cell carcinoma (see Synoptic Report above) F. Ptyergoid muscle, right, biopsy for frozen section Negative for malignancy. Frozen section diagnosis confirmed. G. Masseter margin, inferior, biopsy for frozen section Negative for malignancy. Frozen section diagnosis confirmed. H. Masseter margin, superior, biopsy for frozen section
+
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+Negative for malignancy. Frozen section diagnosis confirmed.. I. Masseter margin, lateral, biopsy for frozen section Negative for malignancy. Frozen section diagnosis confirmed. J. Lingual blood vessel, right, biopsy for frozen section Negative for malignancy. Frozen section diagnosis confirmed K. Pterygoid, medial, biopsy for frozen section Negative for malignancy. Frozen section diagnosis confirmed.. L. Parotid margin, right, biopsy for frozen section Negative for malignancy. Frozen section diagnosis confirmed. M. Medial alveolar, biopsy for frozen section. Negative for malignancy. Frozen section diagnosis confirmed N. Retrotrigone, right, biopsy for frozen section Negative for malignancy. Frozen section diagnosis confirmed O. Mandible margin, anterior, biopsy:. Negative for malignancy. P. Pterygiod margin, new, biopsy for frozen section Negative for malignancy. Frozen section diagnosis confirmed. Q. Lateral parotid, biopsy: Five lymph nodes negative for malignancy (0/5). R. Lymph nodes, level 1-4, right, neck dissection: One of thirty two lymph nodes positive for metastatic squamous cel carcinoma, 2.4 cm maximum dimension. Level IA: (0/3) Level IA: (1/4) Level II: (0/6) Level III: (0/3) Level IV: (0/16) Submandibular gland without pathologic change. S. Lymph nodes, level 1A, neck dissection: Four lymph nodes negative for malignancy.
+
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+T. Maxillary teeth, right, extraction: Maxillary teeth with dental restorations (gross only).. The examination of this case material and the preparation of this report were performed by the staff pathologist. Intraoperative Consult Diagnosis:. FSA: Right facial lymph node: One lymph node negative for malignancy. TAT:7 mins. FSC: Right mental nerve: Negative for malignancy. FSD:Right masseter muscle: Negative for malignancy. FSF: Right pterygoid muscle: Detached necrotic squamous debris. FSC-FSF TAT: FSG: Inferior masseter margin: Negative for malignancy. FSH: Superior masseter margin:. Negative for malignancy. FSI:  Lateral masseter margin: Negative for malignancy. FSJ: Right lingual blood vessel:. Negative for malignancy. FSK: Medial pterygoid Negative for malignancy. FSL: Right parotid margin: Negative for malignancy. FSM:  Medial alveolar: Negative for malignancy. FSN:  Right retro trigone: Negative for malignancy. FSP: New pterygoid margin: Negative for malignancy.
+
+--- Page 5 ---
+FSG-FSP TAT:37 mins. Gross Description: Received are twenty specimen containers, all labeled with the patient name Part A is received additionally labeled "right facial lymph node (FSA)." The specimen consists of predominately yellow lobulated fibrofatty tissues having. aggregate dimensions of 1.5 x 1 x 0.3 cm. Within these tissues there is a single Iymph node candidate which is submitted for frozen section evaluation (FSA) with residual frozen section tissue submitted in cassette A. Part B is received in formalin and additionally labeled, "right Level Ill lymph node" and consists of a single nodular portion of pink-tan soft tissue grossly consistent with lymph node having a dimension of 1 x 0.8 x 0.8 cm. This lymph node is bisected and submitted entirely in cassette B. Part C is received fresh for frozen section evaluation additionally labeled. "right mental nerve (FsC)" and consists of a single 4 mm in greatestdimension gray-tan irregular soft tissue which is submitted for frozen section evaluation (FsC)" with residual frozen section tissue submitted in cassette C. D is received fresh for frozen section evaluation additionally labeled, "right masseter muscle (FSD)" and consists of multiple fragments of red-brown apparent. skeletal muscle having aggregate dimensions of 2 x 1.7 x 0.3 cm submitted for frozen section evaluation (FSD) with residual frozen section tissue submitted in cassette D. Part E is received in formalin additionally labeled, "right buccal mass" and consists of a 12 x 7.5 by up to 7 cm portion of pink-tan to red-brown soft tissue consisting of skeletal muscle, apparent buccal mucosa and being partially surfaced by an ovoid portion of skin with vermillion component. The skin with. the vermillion component has dimensions of 9.5 x 6 cm and the vermillion component has dimensions of 3 x 1.5 x 1 cm. The buccal mucosa is remarkable for a large centrally ulcerated mass which is 6.8 x 5 cm ulcerated to a depth of up to 2.3 cm. The skin bearing component is essentially unremarkable with the exception of a suggestion of submucosal tumor extension to the proximal pole of the vermillion border (see gross photo). The entire circumferential aspect of the specimen is surfaced by tissues which are uninvolved by this tumor. The superior aspect of the specimen is inked ir yellow, inferior aspect is inked green, the superficial aspect not surfaced by skin is inked blue. The proximal aspect is inked red. The distal aspect is inked red on black and the deep aspect is inked black. Those portions of the specimen surfaced by mucosa and/or skin remain un-inked. Please note, these inked regions do not represent true margins (see frozen sections). There is no bony component identified with this specimen..
+
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+The specimen is subsequently step-sectioned proximal to distal to reveal a large centrally necrotic tan-white mass subjacent to the previously described region. of ulceration which has overall dimensions of 8 x 6 x 5 cm. Additionally this lesion approaches to within 0.8 cm of the inferior aspect of the specimen, 0.5 cm of the superior aspect of the specimen and to within 3.5 cm of the proximal skeletal muscle margin of surgical resection and 1 cm of the distal margin of  surgical resection. Additionally this mass courses beneath the more proximal aspect of the vermillion border (see cassette E1) and infiltrates the fatty. tissues with limited necrosis (see cassette E5).. Representative sections of "mass" are submitted in cassettes E1-E5. Also received in the same container is an additional 2 x 1.5 x 1 cm of tan-brown. nodular soft tissue possibly representing lymph node which is bisected and submitted in cassette E6. Part F is received fresh for frozen section evaluation additionally labeled, "right pterygoid muscle (FSF)" and consists of 1.8 x 1 x 0.3 cm of red-brown irregular soft tissue which is submitted for frozen section evaluation (FSF) with residual frozen section tissue submitted in cassette F. Part G is received fresh for frozen section evaluation additionally labeled, "inferior masseter margin (FsG)" and consists of 2.5 x 1.5 x 0.3 cm of red-brown skeletal muscle which is submitted for frozen section evaluation (FSG) with residual frozen section tissue submitted in cassette G.. H is received fresh for frozen section evaluation additionally labeled, "superior masseter margin (FSH)" and consists of a 0.8 x 0.6 x 0.3 cm of fragmented tan-yellow irregular soft tissue which is submitted for frozen section evaluation (FSH) with residual frozen section tissue submitted in cassette H. Part I is received fresh for frozen section evaluation additionally labeled, "lateral masseter margin (FSl)" and consists of multiple fragments of tan-yellow irregular soft tissue 1.5 x 1 x 0.3 cm submitted for frozen section evaluation (FSl) with residual frozen section tissue submitted in cassette I.. Part J is received fresh for frozen section evaluation additionally labeled, "right lingual blood vessel" and consists of a single portion of tan-white. irregular soft tissue which is 0.6 x 0.5 x 0.2 cm submitted for frozen section evaluation (FSJ)" with residual frozen section tissue submitted in cassette J. Part K is received fresh for frozen section evaluation additionally labeled, "medial pterygoid (FSK)" and consists of a 1 x 0.7 x 0.4 cm portion of red-brown soft tissue submitted for frozen section evaluation (FSK) with residual frozen section tissue submitted in cassette K.. Part L is received fresh for frozen section evaluation additionally labeled, "right parotid margin (FSL)" and consists of a 1.3 x 0.8 x 0.4 cm portion of
+
+--- Page 7 ---
+tan-yellow irregular soft tissue submitted for frozen section evaluation (FSL) with residual frozen section tissue submitted in cassette L.. Part M is received fresh for frozen section evaluation additionally labeled, "medial alveolar margin (FSN)" and consists of a strip of tan-yellow soft tissue which is 1.2 x 0.2 x 0.2 cm submitted for frozen section evaluation (FSM) with residual frozen section tissue submitted in cassette M. Part N is received fresh for frozen section evaluation additionally labeled. "right retromolar trigone (FSN)" and consists of a single tan-yellow nodular soft tissue which is 0.9 x 0.8 x 0.3 cm submitted for frozen section evaluation (FSN) with residual frozen section tissue submitted in cassette N. Part O is received in formalin additionally labeled, "anterior mandible margin" and consists of a portion of firm white bone which is 2 x 0.6 x 0.5 cm submitted in toto in cassette O following decalcification.. Part P is received fresh for frozen section evaluation additionally labeled, "new margin pterygoid" and consists of multiple fragments of red-brown irregular. soft tissues having aggregate dimensions of 2.2 x 1.8 x 0.3 cm. These tissues  are submitted for frozen section evaluation (FSP) with residual frozen section tissue submitted in cassette P.. Part Q is received in formalin additionally labeled, "lateral parotid" and consists of multiple fragments of pink-tan irregular soft tissues admixed with fibrofatty tissues all of which have aggregate dimensions of 4.5 x 3 x 2 cm. There is no additional orientation offered or possible with this fragmented specimen. The parotid gland portion of the specimen features yellow lobulated. architecture without distinct masses. Sectioning through the additional soft tissues reveals multiple probable lymph nodes (six) that range from 0.4 to 1.4 cm in greatest dimension. The tissues are submitted as follows:. Q1  essentially unremarkable salivary gland;. Q2  four whole probable lymph nodes;. Q3,4 one whole lymph node each cassette each bisected.. Part R is labeled "right level 1-4 neck dissection, double stitch on 4." The specimen consists of a portion of yellow-tan to red-tan fibroadipose and fibromuscular tissue received with two sutures designated level 4. The specimen has overall dimensions of 13.5 x 8 by up to 2.8 cm. The specimen is divided into levels 1A and 1B, 2, 3 and 4. There is a salivary gland in level 1A that has dimensions of 5 x 2.5 by up to 1.2 cm. Sectioning through the salivary gland reveals a pink-tan, lobulated cut surface. Sectioning through the remaining level 1A reveals three additional lymph nodes up to 1 cm.. The sections from level 1A are submitted as follows:  salivary gland; R2 two whole lymph nodes; R3 one lymph node bisected.
+
+--- Page 8 ---
+Sectioning through level 1B reveals five lymph nodes, which range from 0.5 x 0.4 x 0.4 cm up to 4 x 2.5 x 2.2 cm. The largest lymph node has a tan-white,. degenerative suspicious cut surface. The suspicious lymph node approaches the interface of the salivary gland in level 1A.. The lymph nodes from level 1B are submitted as follows:. R4 one cross section from suspicious lymph node;. R5  two whole lymph nodes; R6  one lymph node bisected. Sectioning through level 2 reveals a few lymph nodes up to 0.6 cm in greatest dimension. These lymph nodes are submitted as follows:. R7  multiple whole lymph nodes; R8  one lymph node bisected. Sectioning through level 3 reveals three lymph nodes up to 2.2 cm in greatest dimension. These lymph nodes are submitted as follows:. R9  one lymph node bisected; R10  one lymph node bisected; R11 one lymph node bisected. Sectioning through level 4 reveals multiple lymph nodes up to 1.1 cm in greatest dimension. These lymph nodes are submitted as follows:. R12-13  multiple whole lymph nodes; R14-16  each with one lymph node sectioned.. Part S is received in formalin additionally labeled, "Level IA neck dissection" and consists of multiple fragments of tan-yellow soft tissue having aggregate dimensions of 3 x 2 x 1 cm. There is no orientation offered or possible with these tissues. By palpation there are two probable lymph nodes 0.5 and 0.7 cm in greatest dimension both of which are submitted in cassette S1. The remaining tissues are submitted entirely in cassette S2 and S3. Part T is additionally labeled, "right maxillary teeth" and consists of three partially fragmented carious teeth some of which have indwelling amalgams and are consistent with bicuspid as well as two molars having dimensions of 2.2 x 1 x 0.8 cm, 2.2 x 1.4 x 0.9 cm and 2.5 x 1.4 x 0.8 cm respectively. No sections are submitted on these gross only tissues. This portion of the case has been reviewed by staff pathologist. Microscopic Description: The histologic evaluation of the specimen demonstrates a poorly differentiated keratinizing squamous cell carcinoma that arises from the buccal mucosa. The tumor is composed of malignant pleomorphic cells arranged in sheets and nest with squamous pearls of keratin in the more well-differentiated areas. The tumor infiltrates through the muscles of the buccal mucosa into the soft tissue of the skin and abuts the mucosa at the vermilion boarder of the lip. The tumor does not extend to the surface of the skin. The tumor involves nerves with areas of angiolymphatic invasion. The surgical resection margins are negative.
+
+--- Page 9 ---
+There is a single lymph node positive for metastatic keratinizing squamous cell carcinoma in slide R4. END OF REPORT
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+page 1 / 2 Department of Cancer Pathology copy No. Date: Examination: Histopathological examination Internal invoice No. Cost of diagnostic procedure Examination No.: Patient: xxx pesEL: XXX Age: Gender: F Material: Total organ resection -- right breast Ics-0-3 Unit in charge: Cuui-onu,nifiltnatuj /muciions 8480f3 Internal referra! Physician in charge: Site: brst, Nos C5U.9 Material collected on: Material received on: 4/1a Expected time of examination: up to 8 working days Clinical diagnosis: Based on PCt, cellulae carcinomatosae -- lesion covering the lower part of the breast. Examination performed on: Macroscopic description:. Right breast sized 27 x 23 x 3 cm removed without axillary tissues and with a skin flap of 27 x 14 cm. Skin injected with blue dye.. Tumour sized 2 x 1.8 x 2.5 cm found on the boundary of lower quadrants, located 3.0 cm from the lower edge, 1.0 cm from the. base and 2.5 cm from the skin. The other tumour sized 3.2 x 1.9 x 4.5 cm found 2 cm away from the first one (margins: lower boundary 1.0 cm, base 1.0 cm, skin. 3 cm). Microscopic description: Carcinoma mucinosum invasivum bifocale - NHG2 (3+2+1/5 mitoses/10 HPF - visual area 0.55mm). Foci of carcinoma ductale in situ (Dcis) found within the tumour (papillary, solid, mucous type, with.  medium nuclear atypia, without necrosis, 20% of the tumour). Carcinoma intraductale mamillae.. Glandular tissue showing parenchymal atrophy. Histopathological diagnosis: Including test No.' Carcinoma mucinosum invasivum et ductale in situ mammae dextrae. Invasive mucinous carcinoma and ductal carcinoma in situ of the right breast. (NHG2, pT2, pNO (sn)) Compliance valid Examination performed on: Results of immunohistochemical examination: Estrogen receptors found in over 75% of neoplastic cell nuclei. Progesterone receptors found in over 75% of neoplastic cell nuclei.. HER2 protein stained using rabbit antibody Ventana PATHwAY HER-2/neu (4B5). Score = 2+ FiSH verification recommended Comoliance validated bv: UUID:D3AC688A-CC8F-475C-8D2E-A8698007094C TCGA-D8-A1XV-01A-PR Redacted
+
+--- Page 2 ---
+page 2 / 2 Examination: Histopathological examination Examination No.: PESEL: XXX Gender: F Patient: xxx Examination performed on: Result of immunohistochemical examination: RESULT OF HER2/neu GENE AMPLIFICATION with the FiSH method by Path Vysion HER2 DNA Probe Kit FINAL RESULT: HER-2 GENE AmPLIFICATION NOT FOUND Compliance validated by: Contact your doctor wIth this RepoRt!
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diff --git a/output/text/acc5d6d7-5518-44e5-a676-ed8628894421.txt b/output/text/acc5d6d7-5518-44e5-a676-ed8628894421.txt
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+BREAST TISSUE CHECKLIST Specimen type: Radical mastectomye Specimen size: Not specified Tumor site: Breast Tumor size: 2.2 x 2.2 x 2 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal and lobular carcinoma. Histologic grade:. Tumor extent: Not specified Lymph nodes: 2/11 positive for metastasis (Axillaris 2/11) 6*0s0 Extracapsular invasion of the lymph nodes: Not specified Left, upper outer Margins: Not specified quadrant soN'tmg Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified -0-401 Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified. Additional pathologic findings: Not specified Comments.. None. Y?ymp-mrF!W wqqnj + Ws yrmyS
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diff --git a/output/text/acc7a709-dc06-44ef-b9c9-26662ec91701.txt b/output/text/acc7a709-dc06-44ef-b9c9-26662ec91701.txt
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index 0000000000000000000000000000000000000000..a10453da367df062ee5a020228ec177a65724962
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+UUID:800346FC-BC14-4A33-B10C-84224D908481 TCGA-OL-A66I-01A-PR Redacted Sample # IeD-3 NO areene ne, unyiltoliey dluet 0 8$0013 Site R%usstuss ass 9 AJs/13 FINAL PATHOLOGIC DIAGNOSIS Lumpectomy and axillary dissection, right breast A. Sentinel lymph node #1, right axilla: -Microscopic focus (1 mm) of metastatic carcinoma. See comment. B. Right breast lumpectomy: -Invasive ductal carcinoma, SBR grade IlI. See parameters below. No in-situ component -Uninvolved breast parenchyma is unremarkable. C. Right axillary contents: -Thirteen lymph nodes, no tumor 0/13 Breast Pathologic Parameters 1. Invasive carcinoma: A. Gross measurement: 1.9 cm B.Composite histologic (modified SBR) grade II -Architecture:3 -Nuclear grade: 3 - Mitotic count: 3 C. Associated ductal carcinoma in situ (Dcis): Not present
+
+--- Page 2 ---
+2.Excisional biopsy margins:Free of tumor -Invasive carcinoma is 2 mm from closest (inferior) margin - Additional margins greater than 2mm away 3.Blood vessel and lymphatic invasion:Absent 4. Axillary lymph nodes: Positive for tumor, (1/14) -Size of largest metastatic deposit: 1 mm -Extranodal extension:Absent 5. Special studies (see ): - Rare tumor cells (less than 1%) immunoreact with ER and PR -Her2/neu antigen (FiSH): Negative (ratio =1.04) 6.pTNM:pT1c,N1mi, MX Clinical History: The patient is a year-old female with a history of right breast mass undergoing right breast lumpectomy and sentinel node biopsy. Comment Cytokeratin stains are performed on the sentinel node (blocks A1 and A2) However, the microscopic focus of carcinoma is not present on the deeper sections used for IHC.
+
+--- Page 3 ---
+Specimens Received: A:Sentinel Lymph Node Right Breast #1 B: Right Breast Lumpectomy C: Right Axillary Contents Gross Description: The specimen is received in three containers, each labeled with the patient' s. name and medical record number. A. Container A is additionally identified as '1. sentinel lymph node, right breast #1.' Received fresh for frozen section diagnosis is a 2.0 x 1.5 x 1.0 cm blue-tan, ovoid lymph node candidate. The specimen is bisected and entirely frozen in cassettes A1FS-A2FS and read as'A1FS-A2FS positive for metastatic tumor < 2 mm'per Dr. The frozen section remnants are entirely submitted in cassettes A1FS-A2FS B.Container B is additionally identified as'2. right breast lumpectomy; long stitch lateral, short stitch superior.' Received fresh and placed in formalin is a 113.8 gm, oriented lumpectomy specimen. The specimen measures 7.2 cm from lateral to medial, 11.0 cm from anterior to posterior, and 3.0 cm from superior to inferior. The specimen is oriented with a double short suture at superior. and a double long suture at lateral.
+
+--- Page 4 ---
+The specimen is inked as follows:. superior blue inferiorblack anterior green posterior red The specimen is serially sectioned from lateral to medial into ten slices. The central aspect of the specimen, within five slices, is notable for a well-circumscribed, centrally spiculated, indurated, otherwise solid, firm, white-pink mass. The mass measures 1.9 x 1.7 x 1.7 cm and abuts both the inferior (black) and inferior/posterior (red/black) margins, diffusely.The second slice from the lateral aspect of the mass shows an identifiable metallic clip. The remainder of the specimen is devoid of additional discrete lesions and is otherwise composed of soft, yellow tissue (85%) and intermixed, glistening and soft, white parenchyma (15%) Block summary: B1-B2:lateral margin, serially sectioned B3-B105: entire specimen from lateral to medial, respectively B106-B107: medial margin, serially sectioned (Mass in cassettes B27, B28, B36-B39, B54-B57, B74-B77; clip in cassettes B36-B39.)
+
+--- Page 5 ---
+C.Container C is additionally identified as'3.right axillary contents. Received fresh is a 8.0 x 5.0 x 2.5 cm portion of lobulated, yellow tissue.The specimen is dissected for lymph node candidates Block summary: C1:five lymph node candidates C2: two lymph node candidates C3:one lymph node candidate, bisected C4:one lymph node candidate, bisected C5: three lymph node candidates C6: three lymph node candidates C7:five lymph node candidates C8: one lymph node candidate, bisected c9: one lymph node candidate, bisected C10: one lymph node candidate, bisected C11: two lymph node candidates C12: three lymph node candidates C13: one lymph node candidate, bisected C14: one lymph node candidate,bisected C15: one lymph node candidate, bisected C16: one lymph node candidate, bisected C17-C19:one lymph node candidate, sectioned (questionable multiple matted lymph nodes)
+
+--- Page 6 ---
+Intraoperative Consult Diagnosis: A1FS-A2Fs. Sentinel lymph node, right breast #1: Positive for metastatic tumor <2 mm. Pathologist Sign Out: h y1iz QUAUFIED
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diff --git a/output/text/acdd6e9e-4ef0-46ea-913d-94b0066d094d.txt b/output/text/acdd6e9e-4ef0-46ea-913d-94b0066d094d.txt
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index 0000000000000000000000000000000000000000..6a4c40964cc58a317d585ff4ecc5d38591429e6e
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+SURGICAL PATHOLOGY REPORT Clinical Diagnosis & History:  year old male 5 cm mass seen in descending colon on colonoscopy 45 cm from anal verge. Specimens Submitted: 1: Sigmoid colon; resection 2: Distal ring 3: Proximal ring DIAGNOSIS: 1. Sigmoid colon; resection:. Tumor Type: Adenocarcinoma Histologic Grade:  Moderately differentiated Tumor Location: Sigmoid colon Tumor Size: Length is 2.5 cm Width is 2.0 cm Maximal thickness is 1.5 cm. Tumor Budding: Focal Increased Tumor Infiltrating Lymphocytes: Absent Precursor Lesions: Tubular adenoma Deepest Tumor Invasion: Muscularis propria Gross Tumor Perforation: Not identified Lymphovascular Invasion: Not identified Large Venous Invasion: Identified Perineural Invasion:  Not identified Surgical Margins: Free of tumor Polyps/Mucosa Dysplasia (away from the carcinoma): ** Continued on next page **
+
+--- Page 2 ---
+Page 2 of 4 Not Identified. Non-Neoplastic Bowel: Unremarkable Lymph Nodes: Total number examined: 17 consistent with prostatic origin, see comment Tumor Staging (AJcc 7th Edition) : pT2 (Tumor invades muscularis propria) Lymph Node Stage (AJcc 7th Edition): N0 (No regional lymph node metastasis) Comment: Immunohistochemical stains show that the tumor cells in the lymph node are positive for PSA, while negative for CK7, Ck2o, CDx-2, TTF-1, chromogranin, and synaptophysin, consistent with a prostate origin. 2. Colon, distal ring; excision: -Benign colonic tissue with hyperplastic changes. Colon, proximal ring; excision: 3 -Benign colonic tissue. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Special Studies: Result Special Stain Comment RECUT Gross Description: 1) The specimen is received fresh and is labeled "sigmoid colon". It consists of an unoriented segment of sigmoid colon that measures 26 x 6 cm. The serosal surface is unremarkable. The radial resection margin is inked black and the specimen is opened to reveal a polypoid tumor that is located 2.4 cm from one margin and 21 cm from the opposite margin. The tumor measures 2.5 cm in length and 2 cm in width. Serial sectioning reveals that the tumor maximum thickness is 1.5 cm. The remaining mucosa is unremarkable. Pericolic adipose tissue spans the entire length of the specimen with a maximum thickness of 12 cm. It is submitted for lymph node dissection and thoroughly examined for lymph nodes,  and all possible nodes are submitted. Representative sections are submitted. Tps is submitted. ** Continued on next page **
+
+--- Page 3 ---
+Page 3 of 4 Summary of sections: M1 - margin closer to the tumor M2  - margin farther from the tumor. T - tumor U - uninvolved mucosa LN lymph nodes BLN - bisected lymph node 2) The specimen is received in formalin, labeled "distal ring" and consists of a ring of pink tan soft tissue measuring 2.5 x 1.8 x 1.3 cm. Multiple sutures and staples are attached. The mucosal surface is pink tan and. focally hemorrhagic. The sutures and staples are removed, and the soft. tissue is entirely submitted. Summary of sections:. U - undesignated 3) The specimen is received in formalin, labeled "proximal ring" and. consists of a ring of pink tan soft tissue measuring 2.0 x 1.8 x 1.4 cm. Multiple sutures and staples are attached..  The mucosal surface is pink tan. and focally hemorrhagic. The sutures and staples are removed, and the soft tissue is entirely submitted. Summary of sections: U - undesignated Summary of Sections: Part 1: Sigmoid colon; resection. Sect. Site Block pCs LN 16 1 M1 1 1 M2 2 4 4 1 U 1 Part 2: Distal ring Block Sect.  Site pCs 2 U 0 ** Continued on next page **.
+
+--- Page 4 ---
+Page 4of Part 3:  Proximal ring Block Sect. site PCs 2 U ** End of Report
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diff --git a/output/text/ace036c5-0ae7-4ae1-820b-26677a9bf94c.txt b/output/text/ace036c5-0ae7-4ae1-820b-26677a9bf94c.txt
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+UUID:A3441B74-07B8-4A9F-9866-0071AD46CB210 CGA-UY-A8OC-01A-PR Redacted SURGICAL PATHOLOgy REPORT Patient Name Accession #: Med. Rec.#: Visit #: Service Date: DOB: Sex: Male Received: Soc. Sec. #: Location: Client: Physician(s): z003 Final Pathologic Diagnosis a ilntmcs JersthIcal N6 S81zof3 Sxt:Y3lodoler Nos C479 A. Right ureter, biopsy: No tumor. Ksoidole cuall NO5 Co79 B. Left ureter, biopsy: No tumor. 9tJ1/z3/14 C. . Bladder and prostate, cystoprostatectomy: 1. Bladder: Invasive urothelial carcinoma with extravesical extension.. 2. Prostate and seminal vesicles: Invasive urothelial carcinoma by direct. extension. 3. No tumor in two lymph nodes (0/2). D. Perivesical fat, biopsy: No tumor. E. Left pelvic lymph nodes, dissection: No tumor (0/10).. F. Right pelvic lymph nodes, dissection: Metastatic carcinoma in one of eleven lymph nodes (1/11). G. Urethra, biopsy: No tumor. H. Final left ureter, biopsy: No tumor.. I. Final right ureter, biopsy: No tumor.. Comment: Bladder Tumor Synoptic Comment. 1. Tumor type: Urothelial carcinoma. 2. Tumor grade: High grade.
+
+--- Page 2 ---
+3. Tumor size: 4.5 cm. 4. Extent of tumor in bladder: Diffusely involves bilateral anterior and posterior walls. 5. Lymphatic/vascular invasion: Not seen. 6. Epithelial abnormalities in bladder: None. 7. Extension of tumor into organs adjacent to bladder: Extends into prostate and seminal vesicles (slide C14). 8. Surgical margins: Urethral margin: Negative.. Right ureter margin: Negative. Left ureter margin: Negative. Perivesical margin: Negative but close (<1 mm to right inferior margin, Slides C1 and C13). 9. Lymph nodes: One of twenty-three (1/23) lymph nodes contains metastatic tumor; the largest  metastatic deposit measures 0.3 cm in greatest dimension; there is no extranodal tumor growth. 10. Other pathologic findings in bladder: None. 11. AJCC/UlCC stage: pT4aN1Mx. 12. Additional comments: There is perineural invasion on Slide C1l. Select slides were shown at the. departmental and the faculty in attendance concurred with the above diagnoses. Specimen(s) Received A:Right ureter (FS) B:Left ureter (FS) C:Bladder and prostate (FS) D:Perivesical fat E:Left pelvic lymph nodes F:Right pelvic lymph node G:Urethra H:Final left ureter I:Final right ureter Intraoperative Diagnosis FS1 (A) Ureter, right, biopsy: No tumor seen. FS2 (B) Ureter, left, biopsy: No tumor seen. FS3 (C) Bladder and prostate, cystoprostatectomy: High-grade invasive urothelial carcinoma. (Dr. Clinical History The patient is a  man with a malignant neoplasm of the bladder. He undergoes a radical cystoprostatectomy and bilateral pelvic lymph node dissection. Gross Description The specimen is received in nine parts, each labeled with the patient's name and medical record number.. Part A is received fresh and is additionally labeled *right ureter.* It consists of a single unoriented, irregular fragment of pink-tan, soft tissue, measuring 0.9 x 0.4 x 0.2 cm. The specimen is entirely submitted for frozen section diagnosis as FS1, with the frozen section remnant submitted in cassette A1. Part B is received fresh and is additionally labeled *left ureter." It consists of a single unoriented, irregular fragment of pink-tan, soft tissue, measuring 0.6 x 0.5 x 0.2 cm. The specimen is entirely submitted for frozen section diagnosis as FS2, with the frozen section remnant submitted in cassette B1. Part C is received fresh and is additionally labeled *4 - bladder." It consists of a bladder with a small portion of prostate, weighing 259 gm and measuring 13.6 cm from superior to inferior, 12.1 cm from right to left, and 4.0 cm from anterior to posterior. The bladder itself measures 6.3 cm from superior to inferior, 5.5 from right to left, and 5.5 from anterior to posterior. The specimen is inked as follows: green ink. anterior right, blue ink anterior left, and black ink posterior. The bladder is opened from the anterior.
+
+--- Page 3 ---
+aspect to reveal a fungating, tan-white tumor in the inferior left and right bladder wall; the tumor measures 4.2 cm from superior to inferior, 4.5 cm from right to left, and 1.8 cm from anterior to posterior. lt approaches the deep margin within O.5 cm. Representative sections are submitted as follows: Cassette C1: Remnant tissue from frozen section (FS3). Cassettes C2-C3: Tumor in relationship to its closest approximation to the inferior, black-inked margin (0.9 cm). Cassette C4: Junction with normal mucosa. Cassette C5: Right anterior. Cassette C6: Right wall. Cassette C7: Right anterior. Cassette C8: Left wall. Cassette C9: Trigone/inferior bladder with base of prostate. Cassette C10: Left wall with tumor approaching the inked margin within 0.3 cm grossly. Cassette C11: Right inferior. Cassette C12: Left seminal vesicle. Cassette C13: Right inferior edge, <1 mm from green-inked margin. Cassette C14: Right seminal vesicle.. Cassettes C15-C16: Candidate lymph nodes.. Part D is additionally labeled "peripelvic fat." lt consists of two unoriented, irregularly shaped fragments of tan-yellow fibrofatty tissue, measuring 2.2 x 1.3 x 0.3 cm and 2.1 x 1.2 x 0.4 cm. The specimen is entirely submitted in cassettes D1 and D2. Part E is received in formalin and is additionally labeled "3) Left pelvic lymph node." It consists of an irregularly shaped, unoriented fibrofatty lymph node packet, measuring 1.5 x 1.3 x 0.4 cm. The specimen is entirely submitted in cassettes E1 through E4, with one bisected lymph node inked in blue in cassette El. Part F is received in formalin and is additionally labeled *right pelvic lymph node." It consists of multiple unoriented, irregularly shaped fragments of fibrofatty lymph node packet, measuring 3.2 x 3.6 x 2.1 cm in aggregate. The specimen is entirely submitted in cassettes F1 through F4, with F1 representing a bisected, blue-inked lymph node.. Part G is received in formalin and is additionally labeled "urethra-inked end is distal." It consists of a segment of urethra, measuring 5.7 cm in length and with a diameter ranging between 1.1 cm and 1.5 cm, with blue ink at one end. The distal half is inked in blue, and the proximal half is inked in yellow. Representative sections from 1-cm intervals are submitted in cassettes G1 through G4 as follows: Cassette G1: Distal blue-inked margin.. Cassette G2: Representative sections from distal half. Cassette G3: Representative sections from proximal half. Cassette G4: Yellow-inked proximal resection edge. Part H is received in formalin and is additionally labeled "8) Final left ureter." lt consists of a single. unoriented, irregularly shaped fragment of ureter with attached fibrofatty tissue. The tan-white ureter measures 0.5 cm in diameter and 0.6 cm in length. The overall dimensions of the specimen with the attached fibrofatty tissue is 2.5 x 0.7 x 0.3 cm. The specimen is inked in blue, the ureter is bisected and is submitted in cassette H1, and the remainder of the tissue is entirely submitted in cassette H2. Part l is received in formalin and is additionally labeled "#9 final right ureter." lt consists of a single unoriented, irregularly shaped fragment of tan-white ureter, measuring 0.3 cm in diameter and 0.6 cm. The overall dimensions of the specimen with attached fibrofatty tissue is 1.0 x 0.5 x 0.3 cm. The specimen is inked in blue, sectioned, and entirely submitted in cassette l1. Diagnosis based on gross and microscopic examinations. Final diagnosis made by attending pathologist following review of all pathology slides. Pathology Resident /Pathaloaist Electronically signed out on lud1191F3
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diff --git a/output/text/ace98e97-6839-4874-93b0-0dd4de04af38.txt b/output/text/ace98e97-6839-4874-93b0-0dd4de04af38.txt
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+UUID:1F6200B4-B53B-4E9F-B01B-12D2C0D4270E TCGA-AN-A03X-01A-PR Redacted TSS Patient ID: Case #: DOB: Sex: Female Ethnicity (Race): Cancer Samplee Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma Date of Procurement: Anatomic Site: Left Breast Tumor location: Primary. Tissue Specification: Tumor Specimen Matrix: Tissue Specimen Format: Frozen Container: cryomold Type of Procurement: Radical mastectomy Grade: 1 T Stage: 2 N Stage: 0 M Stage: 0 Treatment: none. Treatment Details: n/a Normal Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw. Matrix: Blood Specimen Format: frozen Container: tube. Date of Procurement 1cs-0-3 Civcinona, nfiItstny duct nos 85oc/3 Sit, buust, Nos C5e.9 10/21/1
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diff --git a/output/text/acf0f2d8-1d2b-4e84-b554-6a9207b2bdb4.txt b/output/text/acf0f2d8-1d2b-4e84-b554-6a9207b2bdb4.txt
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index 0000000000000000000000000000000000000000..351aa1dff973676f238837a3c44b30cda99282ab
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+FINAL DIAGNOSIS Part 1: GallBlAdder, Cholecystectomy - AcuTE And CHronIc CaLCuLoUs ChOlecyStiTIS. nO eVIdeNcE Of maLIgnaNCy. PARt 2: gaLlStoneS, RemOVAL - CHOLELITHIASIS (gross diagnosis). PArt 3: Left KidNey AnD Left ADrenAl GLAnD, ResEctiOn - A.  RENAL CELL CARCINOMA, CONVENTIONAL TYPE (CLEAR AND GRANULAR CELL FEATURES), EXTENSIVELY iNVOLVING THE LEFT KIDNEY-AND FOCALLY iNVOLVING THE RENAL PELVIS (slide 3l). B.  MAXIMAL TUMOR DIMENSION IS 11 CM. C.  PREDOMINANT FUHRMAN NUCLEAR GRADE IS 2I4 WITH FOCAL AREA OF FUHRMAN NUCLEAR GRADE 3/4 (slide 2I), ASSOCIATED WITH FOCAL TUMOR NECROSIS. D.  TUMOR IS CONFINED BY CAPSULE, WITH NO CARCINOMATOUS EXTRACAPSULAR EXTENSION. E. OCCLUSIVE CARCINOMATOUS THROMBUS WITHIN LARGE RENAL VEIN ($IIde 3C). F. URETER, PERIRENAL SOFT TISSUE AND ALL SURGICAL RESECTION MARGINS ARE BENIGN. .ONe BENIGN ADreNAL gLAND AND ONe (1) BENigN PERIRENAl HILAR LyMph NODE H.  NON-NeOpLASTIC KIDnEy WITh ArTEriAl AND ARTeRiOLAR SCLEROSIS, CHrONiC INTERSTITIAL INFLAMMATION AND FOCAL ACUTE TUBULITIS, WITH AGE APPROPRIATE GLOMERULAR AND TUBULOINTERSTITIAL CHRONICITY CHANGES. PATHOLOGIC STAGE: T3b, NX, MX. (See microscoplc description). PART 4: SmALL INTESTINE, SEGMENTAL RESECTION : Segment Of benIgn Small INtestine wIth focal. Surgical dEfect, OtherwIse, nO SpecifIC PATHOLOGIC ABNORMALITY. NO EVIDENCE OF MALIGNANCY. Final Diagnosis LUNG LEFT UPPER LOBE, FINE NEEDLE ASPIRATION BIOPSY: METASTATIC RENAL CELL CARCINOMA. SEE COMMENT. Comment: The aspirates are pauci-cellular and reveal rare small clusters of malignant epithelial cells in a background of blood. Only rare reactive bronchial cells and sparse inflammatory cells are present. The tumor cells are large with abundant granular cytoplasm and well defined cell borders. The nuclei are enlarged and mildly pleomorphic with moderately irregular contours, coarse chromatin and prominent central nucleoli. The morphologic findings are consistent with a renal cell carcinoma. To confirm the diagnosis and help exclude a primary lung tumor, we performed a panel of immunohistochemical stains on the cell block material with the following results: Antibody Usual reactivity. Result CD10 Renal cell marker,. Positive Pan-keratin Epithelial marker Positive CK 7 Epithelial marker. Positive CK 20 Epithelial marker. Negative RCC Renal cell marker Negative CD 68 Histiocyte marker Negative TTF-1  Pulmonary cell marker. Negative The immunohistochemical staining pattern supports the morphologic diagnosis. Positive staining for CD10 and pan keratin with negative staining for CK 20 is consistent with renal cell carcinoma. Although CK7 is often negative in most renal cell carcinomas, positive staining can be seen in up to 1/3 of cases. Similarly, negative staining for RCC is seen in approximately 13% of cases. Negative staining for CD68 indicated the tumor cells are not reactive pulmonary macrophages which can have similar morphology in rare cases. Negative staining for TTF-1 also rules against a diagnosis of a primary lung carcinoma. Overall, based on rnholooy and immunohistochenica findings the final diagnosis is that of metastatic renal cell carcinoma. nave reviewed this case and concur with the diagnosis. Lung, Left, nodule, fna: LESS THAN OPTIMAL - SCANT CELLULARITY. NEGATIVE FOR MALIGNANT CELLS. HYPERCELLUALR SPECImEN WITH REACTIVE EPITHELiAL CELLS AND BLOOD (see comment) Comment: Because of the minute size of the lesion and technical difficuity of this biopsy, a limited sampling was obtained. No definitive evidence of malignancy identified. Immunohistochemical stains for CD10, RCC and CD68 are non-contributory. Additional studies should be considered if clinically indicated.
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diff --git a/output/text/ad42cbc0-5754-4870-9c08-662799295145.txt b/output/text/ad42cbc0-5754-4870-9c08-662799295145.txt
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+--- Page 1 ---
+TCGA-B9-5156 Surgical Pathology Report Diagnosis: Left kidney, partial laparoscopic nephrectomy  Histologic tumor type/subtype: renal cell carcinoma, papillary subtype Histologic grade (if applicable): Fuhrman grade 3 of 4 Tumor size (greatest dimension): 1.7 cm Extent of tumor invasion: Capsular invasion/perirenal adipose tissue: Tumor invades into renal capsule; perirenal fat negative for carcinoma Gerota' s fascia: negative for carcinoma Renal vein: not applicable Ureter: not applicable Venous (large vessel): not identified Lymphatic (small vessel): not identified Histologic assessment of surgical margins: Perirenal adipose tissue: negative for malignancy Gerota' s fascia: negative for malignancy Adrenal gland: not present Lymph nodes: none identified Other significant findings: - Tumor is 0.5 cm from the surgical margin. - Mild glomerulosclerosis and arteriosclerosis. - Benign simple cyst.. AJCC Staging: pT1a pNx This staging information is based on information available at the time of this report, and is subject to change pending clinical review and additional information. Clinical History: The patient is with a clinical diagnosis of a left renal mass. As, radiology showed an enhancing left renal mass, suspicious for renal cell carcinoma. Gross Description:. Specimen fixation: Formalin Type of specimen: Partial, laparoscopic Side of specimen: Left. Size and weight of specimen: 17.3 grams; 3.6 x 3.5 x 2.9 cm Orientation: The capsule has been previously inked black and the parenchymal margin of resection has been inked
+
+--- Page 2 ---
+blue. Presence/absence of adrenal gland: Absent. Tumor description/site: The tumor is located in the cortex of the kidney and directly abuts the capsule; the lesion appears encapsulated and is yellow/brown in color with no cysts identified.. Tumor size: 1.7 x 1.5 x 1.4 cm. Presence/absence of multicentricity: Absent (cannot assess without complete nephrectomy). Confinement/non-confinement to the kidney: Confined Extent of invasion:. Perirenal adipose tissue: Tumor does not grossly involve. Gerota' s fascia: Does not grossly involve. Renal vein: Not present Ureter: Not present Other organs: Not applicable Surgical margins: Perirenal adipose tissue: Negative, directly adjacent Renal vein: Not present Renal artery: Not present Ureter: Not present Description of kidney away from tumor: Tan/brown tissue with the average cortex measuring 4.6 cm in average  medullary area measuring 1.0 cm. Lymph nodes (hilar): Not present Other significant findings: The tumor is located 0.5 cm away from the blue inked parenchymal margin of resection Tissue submitted for special investigations: Yes. Digital photograph taken: No Block Summary: Inking: Capsule/black, parenchymal margin of resection/blue. A1 - Perinephric fat margin A2 - Tumor with closest approach margin of resection. A3-A7 - Additional sections of tumor A8 - Normal kidney. Light Microscopy: Light microscopic examination is performed
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diff --git a/output/text/ad892f98-f49e-46d8-a19b-3aead3974f4f.txt b/output/text/ad892f98-f49e-46d8-a19b-3aead3974f4f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8c2b42358d712466a282c265675a8c8023a77886
--- /dev/null
+++ b/output/text/ad892f98-f49e-46d8-a19b-3aead3974f4f.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:C07E8EA7-A221-40F9-9D19-A59DE0E52200 TCGA-OR-A5KP-01A-PR Redacted ZCD o 3 )arem Procedure: L adrenalectomy 8370/3 Gross description: 10 x 8 x 8.5cm, 196g AdreualClul Sit CDr+ex C74.D Diagnosis: adrenocortical carcinoma Reference Pathology: Js/13 Diagnosis: adrenocortical carcinoma Weiss score: 6 Hough score: 3.9 Van Slooten score: 9
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diff --git a/output/text/ad8ba03c-1820-4fa3-9671-93f709a2a027.txt b/output/text/ad8ba03c-1820-4fa3-9671-93f709a2a027.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d6806c618fc190fcf487ea9c412acc174dd4f8d0
--- /dev/null
+++ b/output/text/ad8ba03c-1820-4fa3-9671-93f709a2a027.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:6CF5659C-C6A7-4019-B368-86A6525D40350 TCGA-E7-A519-01A-PR Redacted 1c s- 0- 3 carunmn,t^snsiHionel cll,N1s 813of3 Gross Description: PiH Site: b1eddw, NoS c47-9 Microscopic Description: b1sddv, wnlL,NO5 C&7.9 CQcF Diagnosis Details: "/a(1) Comments: Formatted Path Reports: BLADDER TISSUE CHECKLIST Specimen type: Excision of tumor Tumor site: Bladder Tumor size: 6 x 5 x 3 cm Tumor features: Papillary Histologic type: Transitional cell carcinoma. Histologic grade: Well differentiated. Tumor extent: Deep muscle. Lymph nodes: Not specified. Lymphatic invasion: Not specified Venous invasion: Not specified. Margins: Not specified Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified. Comments: None 118/
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diff --git a/output/text/adb09650-986b-46ab-a843-d0d09180c07c.txt b/output/text/adb09650-986b-46ab-a843-d0d09180c07c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..494da29ba820756386aac84f4c385bbb4d8c9f29
--- /dev/null
+++ b/output/text/adb09650-986b-46ab-a843-d0d09180c07c.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:83BCCC3C-0384-45CD-84B4-67E2EDE822EE TCGA-AC-A62Y-01A-PR Redacted Sex Female 1.0.B.: RN ef Phy Collected: Accession #: Received: Acct I Reg #: Reported SURGICALPATHOLOGYREPORT DIAGNOSIS: ICD-O-3 Right breast moafied radical mastectomy: Two areas of invasive lobular carcinoma. Sizes:2.8 and 1.8 cm Architectural score: 3 of 3. LsbuLor NOsO 852df3 Nuclear score: 2 of 3. Mitotic score: 1 of 3. Total score:  of 9. Grade 2. Extensive lobular carcinoma in situ present. No evidence of angiolymphatic invasion. No evidence of skin and nipple invalvement.. Prognostic was previously performed and will not be repeated unless requested Deep margin of excision is invclved by carcinoma. D s|1s/13 Attached axillary Jymph node: One lymph node, meiastatic carcinoma present Size:D.4 cm No avidence of extracapsular extension.. TMN: T2pN1 Electronic Signature: CUNICAL HISTORY:  Preoperative Diagnosis: Right moditied radical mastectomy with sentinel node mapping with frozen section. Invasive lobular carcinoma. ER positive, PR positiveHer-2 negative Postoperative Diagnosis: Symplams/Radiologic Findings: SPECIMENS: Right breast SSPECIMENDATA GROSS DESCRIPTION:S The specmen is recsived in formalin labeled with the patient's name sht breast. The specimen consists ot a portion of fbroadipose  brezst tissua and overlying skin measuring 20.0 x 15.0 x 6.0 cm and weighs 448 grams. The skin surtace measures 15.0 x 10.5 cm and is light tan wrinkled. There is slight puckering of the skin surface noted that measures 2.0 cm that is 8.5 cm from the nipple. The nipple is eccentrically placed and appears grossly unremarkable. There is no orientation given to the specimen. The deep margin is inked. Sectioning reveals gray-tan mass measuring 1.8 x 1.5 x 1.5 cm that is 0.1 cm from the deep margin. it is located at the periphery of the breast. A second mass measuring 2.8 x 2.5 x 2.5 cm that is  0.1 cm from the deep margin, 0.2 cm from the skin surface, corresponds to the puckered area noted previously mentioned on the skin surface. The  surrounding tissue reveals yellow-tan fatty fibroadipose tissue predominantiy with areas of gray fibrous tissue. No other lesions are identmea. Un the one greenone yellow. one ciue labeled epresentative sections are submitted in cassettes labeled  folows: nipple, block 1; sections from the first leslon in biocks  tnrougn o; sections from the second lesion in blocks 6 through 9; poss:e symph node sectioned in tota) in hlocks 10 through 12; random ssctions from all four quadrants in blocks 13 through 16. HIPAA Discre pan Fmor Malig
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diff --git a/output/text/adbeb903-92f8-4766-846d-290541ee065a.txt b/output/text/adbeb903-92f8-4766-846d-290541ee065a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4e5b5f75a787d58fffe63221e524fe58cd6219fc
--- /dev/null
+++ b/output/text/adbeb903-92f8-4766-846d-290541ee065a.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+Redacted ICDO3 Surgery date:  Surgical Pathology serscorenmo, ductN6S REVISED REPORT (Revised information underlined) 880D|3 Site: Sancreas heaol DIAGNOSIS: D. Pancreas, head, duodenum, gallbladder, and common bile duct, C86.0 portion jejunum, pyloro-sparing Whipple resection: Invasive grade 3 JtJ s/s/1 y (of 4) ductal adenocarcinoma is identified forming a solid 4.0 x 3.0 x 3.0 cm mass causing a stricture of the distal common bile duct. The tumor extends beyond the pancreas to involve the peripancreatic. soft tissue. It infiltrates into the muscularis propria of the duodenal wall and the adventitia of superior mesenteric vein (a 4.0 cm segment of superior mesenteric/portal vein resected on block is present). Perineural invasion is present. Tumor necrosis is absent. All surgical resection margins are negative for tumor (minimum tumor free margin, less than 0.1 cm, anterior soft tissue margin). Multiple (5 of 34) regional lymph nodes are positive for metastatic adenocarcinoma. The gallbladder is unremarkable. A. Lymph nodes, hepatic artery, biopsy: Multiple (2) lymph nodes are negative for tumor. B. Pancreas, neck margin, excision: Positive for tumor. A lymph node is also metastatically involved. C. Pancreas, body margin, excision: A microfocus of carcinoma is present. E. Vein, superior mesenteric, margin, excision: Negative for tumor. F. Vein, portal margin, excision: Negative for tumor. G. Hepatic duct, margin, excision: Invasive adenocarcinoma is present in the soft tissues surrounding hepatic duct nearly circumferentially. H. Hepatic duct, new common margin, excision: Negative for tumor With available surgical material, [AJCC pT3N1] (7th edition, 2010) Frozen section histologic interpretation of hepatic artery lymph nodes, neck of pancreas margin, and body of pancreas margin, performed by:. This final pathology report is based on the gross/macroscopic examination and the frozen section histologic evaluation of the specimen(s). Hematoxylin and Eosin (H&E) permanent sections are reviewed to confirm these findings. Any substantive changes
+
+--- Page 2 ---
+identified on permanent section review will be reflected in a revised report. Interpreted by:  Report electronically signed by Transcribed by: AMENDMENTS: (Previous Signout Date: Revision Description: Part C: On permanent section, a microscopic focus of invasive carcinoma is identified involving the pancreas body margin. On review of frozen section slides, two small malignant glands are identified, originally misinterpreted as reactive. ....Original Diagnosis... D. Pancreas, head, duodenum, gallbladder, and common bile duct, portion jejunum, pyloro-sparing Whipple resection: Invasive grade 3 (of 4) ductal adenocarcinoma is identified forming a solid 4.0 x 3.0 x 3.0 cm mass causing a stricture of the distal common bile duct. The tumor extends beyond the pancreas to involve the peripancreatic soft tissue. It infiltrates into the muscularis propria of the. duodenal wall and the adventitia of superior mesenteric vein (a 4.0 cm segment of superior mesenteric/portal vein resected on block is present). Perineural invasion is present. Tumor necrosis is absent. All surgical resection margins are negative for tumor (minimum tumor free margin, less than 0.1 cm, anterior soft tissue margin). Multiple (5 of 34) regional lymph nodes are positive for metastatic adenocarcinoma. The gallbladder is unremarkable.. A. Lymph nodes, hepatic artery, biopsy: Multiple (2) lymph nodes are negative for tumor. B. Pancreas, neck margin, excision: Positive for tumor. A lymph node is also metastatically involved. C. Pancreas, body margin, excision: Margin is negative for tumor. Invasive carcinoma is present 0.2 cm away from the resection margin E. Vein, superior mesenteric, margin, excision: Negative for tumor. F. Vein, portal margin, excision: Negative for tumor. G. Hepatic duct, margin, excision: Invasive adenocarcinoma is present in the soft tissues surrounding hepatic duct nearly. circumferentially. H. Hepatic duct, new common margin, excision: Negative for tumor.
+
+--- Page 3 ---
+With available surgical material, [AJCC pT3N1] (7th edition, 2010) Frozen section histologic interpretation of hepatic artery lymph nodes, neck of pancreas margin, and body of pancreas margin, performed by: This final pathology report is based on the gross/macroscopic examination and the frozen section histologic evaluation of the specimen(s). Hematoxylin and Eosin (H&E) permanent sections are reviewed to confirm these findings. Any substantive changes identified on permanent section review will be reflected in a revised report. ***Signing Pathologist**** GROSS DESCRIPTION: A. Received fresh labeled "hepatic artery lymph nodes" is a 1.1 x 1.0 x 0.4 cm aggregate of adipose and lymphatic tissue. Lymph nodes submitted. Grossed by B. Received fresh labeled "neck of pancreas margin" is a 3.2 x 2.1 x 0.5 cm portion of pancreatic tissue with orientation. All submitted. Grossed by C. Received fresh labeled "body of pancreas margin" is a 3.8 x 2.6 x 1.0 cm portion of pancreas with orientation. Representative sections are submitted. Grossed by. D. Received fresh labeled "head pancreas, gallbladder, duodenum, common bile duct, portion jejunum" is a Whipple specimen consisting of 27.0 cm in length of portion of duodenum, 6.0 x 4.0 x 4.0 cm portion of pancreas, a 4.0 cm segment of superior mesenteric vein/portal vein, and a 12.0 x 4.0 x 4.0 cm gallbladder. The pancreatic uncinate margin is inked yellow and shaved, the portal vein groove is inked black and submitted perpendicularly. There is a 4.0 x 3.0 x 3.0 cm diffusely infiltrative mass within the. pancreatic head, 0.9 cm from the neck margin. The mass extends to portal vein and duodenum. The gallbladder contains no choleliths. Peripancreatic lymph nodes and periduodenal lymph nodes are identified. Representative sections are submitted. Grossed by E. Received fresh labeled "SMV margin" is a 1.0 x 1.0 x 0.4 cm portion of blood vessel with orientation. All submitted. Grossed by
+
+--- Page 4 ---
+F. Received fresh labeled "portal vein margin" is a 1.0 x 1.0 x 0.2 cm portion of blood vessel with orientation. All submitted. Grossed by G. Received fresh labeled "hepatic duct margin" is a 1.1 x 1.1 x 0.6 cm portion of hepatic duct with orientation. Margin submitted. Grossed by H. Received fresh labeled "new common hepatic duct margin" is a 0.6 x 0.5 x 0.3 cm portion of pink-tan tubular soft tissue with orientation. Margin submitted. Grossed by BLOCK SUMMARY: Part A: Hepatic artery Lymph Nodes 1 Hepatic artery LN 2 (A1) Part B: Neck of pancreas Margins 1 Neck of pancreas 1 2 Neck of pancreas 2 3 Neck of pancreas 3 Part C: Body of pancreas margin 1 Body of pancreas margin1 2 Body of pancreas margin2 3 Peripancreatic LN ? 1(C1) Part D: Head pancreas, gallbladder, duodenum, common bile duct, portion jejunum 1 Uncinate margin 1 2 Uncinate margin 2-bottom 3 Uncinate margin 2-top 4 Periduodenal LNs 4(D1) 5 Periduodenal LNs 1(D2) 6 Periduodenal LNs 5(D3) 7 Periduodenal LNs 3(D4) 8 Peripancreatic LNs 3(D5) 9 Peripancreatic LNs 3(D6) 10 Ampulla 11 Common bile duct 12 Duodenum 13 Portal/sup mesenteric vein 14 Pancreatic head 15 Peripancreatic LNs 2(D7) 16 Peripancreatic LNs 2(D8) 17 Peripancreatic LNs 1(D9) 18 Peripancreatic LNs 3(D10) 19 Peripancreatic LNs 3(D11) 20 Peripancreatic LNs 3(D12)
+
+--- Page 5 ---
+21 Gallbladder 22 Peripancreatic LNs 2(D14) 23 Peripancreatic LNs 3(D15) 24 Peripancreatic LNs 3(D16) Part E: SMV margin 1 Sup mesenteric vein margin. Part F: Portal vein margin 1 Portal vein margin Part G: Hepatic duct Margins 1 Hepatic duct margin Part H: New common hepatic duct Margins 1 New comm hepatic duct mg hillohy
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diff --git a/output/text/add1509d-b373-4aa4-a17e-a24b4eebddbf.txt b/output/text/add1509d-b373-4aa4-a17e-a24b4eebddbf.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ca807c565effa75f33b7fd4856bc245d94ff6903
--- /dev/null
+++ b/output/text/add1509d-b373-4aa4-a17e-a24b4eebddbf.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID: 56907DFB- EB0B-4906-9DEC-781A9BA805420 TCGA-2Z-A933-01A-PR  Redacted Pathology Report Final Diagnosis A. RIGHT KIDNEY CORE BIOPSY: Positive for carcinoma. B. RIGHT KIDNEY, NEPHRECTOMY: Renal cell carcinoma, papillary type ll. See Key Pathologic Findings.. Surgical margins, free of malignancy. Pathologic stage: pT1a NX MX. I, the attending pathologist, personally reviewed all.. siides and / or materials and rendered the final diagnosis. Electronically Signed Out by Comment There are focal mucinous changes Ancillary Studies Immunoperoxidase stains (cytokeratin 7, cytokeratin 20, AMACR and vimentin) performed with appropriate positive and negative controls on block 10 support the diagnosis.. Key Pathological Findings B: Kidney Resection PROCEDURE: SPECIMEN TYPE: Nephrectomy SPECIMEN LATERALITY: Right TUMOR SIZE (largest tumor if muitiple): Dimension: 3.0 cm MACROSCOPIC EXTENT OF TUMOR: Tumor limited to kidney HISTOLOGIC TYPE: Papillary renal cell carcinoma SARCOMATOID FEATURES: Not identified TUMOR NECROSIS: Present 5% HISTOLOGIC GRADE (Fuhrman Nuclear Grade G3: Nuclei very irregular, approximately 20 microns; nucleoli large and prominent. MICROSCOPIC TUMOR EXTENSION: Tumor limited to kidney MARGINS: Vascular, ureteral and surgical margins, uninvolved by carcinoma ADRENAL GLAND: z@D-0:3 Careensin,yorypsilery ren uQQ 8Q6t/3
+
+--- Page 2 ---
+Not present PERINEURAL INVASION: Absent ANGIOLYMPHATIC INVASION: Absent LYMPH-VASCULAR INVASION Absent PRIMARY TUMOR (pT): pT1a:Tumor 4 cm or less in greatest dimension, limited to the kidney. REGIONAL LYMPH NODES (pN): pNX:Regional lymph nodes cannot be assessed DISTANT METASTASIS (pM): pMX Specimen(s) Received A CORE BIOPSY RIGHT KIDNEY FS B RIGHT NEPHRECTOMY Preoperative Diagnosis Right renal mass.. Frozen Section Diagnosis FSA1 AND TOUCH IMPRINT: CORE BIOPSY OF RIGHT KIDNEY: Positive for carcinoma. Comment: This frozen section diagnosis/result was communicated to and acknowledged by Dr. M.D., nave performed the intraoperative consultation (s) and issued the above. diagnosis. Gross Description A. The specimen is received fresh in 2 containers. Specimen A is labeled, *core biopsy, right kidney". The specimen consists of 3 core biopsy fragments of pink-tan tissue which are ranging from. 1.5 to 2.5 cm in length. Touch and print of the specimen is prepared for cytological evaluation. The specimen is submitted entirely for frozen section as FSA1.. B. Specimen B is labeled, *right nephrectomy". The specimen consists of a partial nephrectomy which measures 4.5 x 3.5 x 3 cm, weight 26g. The renal capsule is tan-red, brown, focally hemorrhagic, smooth and glistening. Prior to sectioning, the specimen is inked as follows: Parenchymal resection margin: Black. Capsular surface.d Blue. The specimen is serially sectioned to reveal an irregular to roughly ovoid, ill detined, rubbery intraparenchymal tumor which measures 3 x 2.5 x 2.5 cm. The tumor bulges capsule and partially involves central area of the parenchymal resection margin. Cut surface of the tumor is tan-gray to pink, focaly hemorrhagic, without evidence of necrosis. Aiso received in the same container,
+
+--- Page 3 ---
+completion nephrectomy specimen including a kidney (10.5 x 5.5 x 3.5 cm, weight 116 g) which is surrounded by perinephric adipose tissue ranging from 1 to 2.5 cm in thickness. There is a 3 cm length of ureter attached to the kidney, which is grossly unremarkable. There is a partial nephrectomy site on the lateral aspect of the kidney measuring 4 x 3.5 x 2.5 cm. Prior to sectioning, the specimen is inked as follows:. Perinephric adipose resection margin:. Orange. Renal capsule surrounding partial nephrectomy site: Black. Deep aspect of the partial nephrectomy site:. Black. The deep aspect of the partial nephrectomy site extends to the renal pelvis, partially involving it. The urothelium of the renal pelvis adjacent to the nephrectomy site is focally hemorrhagic. No residual tumor is grossly identified within the renal parenchyma and renal pelvis adjacent to the partial nephrectomy site. The remaining renal parenchyma and urothelium of the caliceal system, renal pelvis, and a portion of the ureter are grossly unremarkable. The renal artery, renal vein and their branches are grossly unremarkable and do not appear to be involved by the tumor. No lymph nodes are grossly identified within the hilar adipose tissue. No adrenal gland is found within the perinephric adipose tissue. Representative sections of the specimen were submitted to the Tissue Procurement Laboratory. Representative sections of the specimen are submitted in 23 cassettes, as follows: B1: Resection margin of the ureter. tangential section B2: Resection margins of the renal artery and vein, tangential sections. 83 and B4 Perinephric adipose tissue resection margin closest to the tumor, perpendicular cross sections. B5-B12:Representative sections of the tumor,bulging capsule, and involving the deep aspect of nephrectomy specimen. B13-818: Deep aspect of the partial nephrectomy site adjacent to the tumor with a portion of renal pelvis. B19-822 Additional sections of the deep aspect of partial nephrectomy site. 823 Grossly unremarkable renal parenchyma.. DISQUALIFIED
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diff --git a/output/text/ae2d6b4f-16cc-4daf-b964-b3ca53bdeb08.txt b/output/text/ae2d6b4f-16cc-4daf-b964-b3ca53bdeb08.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fdf9050f4eb408cdf6a3393d8b184320e06a6bb4
--- /dev/null
+++ b/output/text/ae2d6b4f-16cc-4daf-b964-b3ca53bdeb08.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+Clinical Diagnosis & History:  y/o female with two foci of carcinoma right breast 10:00/subareolar (FNA  malignant) and 1l:00/uoq (core biopsy invasive ductal carcinoma). For right wide excision, SLNb, possible ALND.. Specimens Submitted: SP: Sentinel node #1 level one right axilla (fs) (.. UUID:0BFAB667-8840-46AE-A224-535573E268C7 2: SP: Sentinel node #2, level one right axilla (fs) TCGA-AO-A03P-01A-PR  Redacted 3: Sp: Wide excision of tumor right breast 10:00 ( DIAGNOSIS: 1) SENTINEL LYMPH NODE #1, LEVEL I, RIGHT AXILLA; BIOPSY: - ONE BENIGN LYMPH NODE. - DEEPER LEVEL RECUTS AND SPECIAL STAINS HAVE BEEN ORDERED. RESULTS WILL BE REPORTED IN AN ADDENDUM. THE 2) SENTINEL LYMPH NODE #2, LEVEL I, RIGHT AXILLA; BIOPSY: - ONE BENIGN LYMPH NODE. - DEEPER LEVEL RECUTS AND SPECIAL STAINS HAVE BEEN ORDERED. THE RESULTS WILL BE REPORTED IN AN ADDENDUM.S 3) BREAST, RIGHT, 10:0O; WIDE BXCISION: - INVASIVE DUCTAL CARCINOMA, NOS TYPE, HISTOLOGIC GRADE III/III (SLIGHT OR NO TUBULE FORMATION), NUCLEAR GRADE III/III (MARKED VARIATION IN SIZE AND SHAPE), PRESENT AS THREE SEPARATE NODULES, RANGING IN SIZE FROM 1.O CM UP TO 3.7 CM. - DUCTAL CARCINOMA IN SITU (DCIS) IS ALSO IDENTIFIED, SOLID TYPE WITH HIGH NUCLEAR GRADE AND MINIMAL NECROSIS.S - THE DCIS CONSTITUTES <- 25% OF THE TOTAL TUMOR MASS, AND IS PRESENT ADMIXED WITH AND AWAY FROM THE INVASIVE COMPONENT. - NO CALCIFICATIONS ARE IDENTIFIKD IN EITHER THE INVASIVE OR IN SITU CARCINOMA. NO VASCULAR INVASION IS NOTED. - INVASIVE CARCINOMA IS O.15 CM FROM THE NEAREST (SUPERIOR) MARGIN AND 0.4 CM FROM THE POSTERIOR MARGIN. - THE NON-NEOPLASTIC BREAST TISSUE IS UNREMARKABLE. - RESULTS OF SPECIAL STAINS (ER, PR, HER2-NEU) WILL BE REPORTED AS AN ADDENDUM. ** Continued on next page ** 1cs-0-3 10/21/n tw 10/a1/11
+
+--- Page 2 ---
+Page2 I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OFS THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT.  Report Blectronically Signed Out *** Special Studies: Result Special Stain POSITIVE AE1:AB3 nent NEG CONT IMM RECUT AE1:AE3 AE1:AE3 NEG CONT IMM RECUT ER-C pR-C HER2-C NEG CONT NEG-HER2 IMM RECUT ntion 1) The specimen is received fresh for frozen section diagnosis, labeled, "Sentinel node #1, level one, right axilla". It consists of a single lymph. node, measuring 0.8 x 0.7 x 0.5 cm.. frozen.  The lymph node is bisected and entirely. Sumnary of Sections: FSC  frozen section control 2) "Sentinel node #2, level one, right axilla".. It consists of a single lymph. node, measuring 0.5 x 0.5 x 0.5 cm.. Bisected and entirely submitted. Summary of Sections: FSC  frozen section control 3) The specimen is received fresh, labeled, "wide excision of tumor. right breast 10:0o (short stitch superior, long stitch lateral)". It. consists of an ovoid to irregular piece of yeliow lobulated adipose tissue,. measuring about 9.5 x 7.5 x 4.0 cm in greatest dimension.. oriented with a short stitch at the superior aspect and a long stitch at the. The specimen is lateral margin. The specimen is inked as follows: superior-blue,. ** Continued on next page **.
+
+--- Page 3 ---
+inferior-red, posterior-black, anterior-yellow. Serial sections of the. well-circumscribed, tan lesion, located about 1.0 cm from the superior,. inferior, and medial margins.. The tumor is closest to the anterior and posterior margin and is at a distance of o.5 cm from either of them.. Surface of the tumor reveals a tan, slightly granular appearance. Cut cm superior and lateral to the main mass are two smaller well-circumscribed About 1.0 nodules, the larger of which measures 2.2 x 1.3 x 1.0 cm.. well-circumscribed nodule is < 0.2 cm from the superior margin and is.  This fairly located about 1.0 cm from the lateral and 0.5 cm from the posterior margin. About 0.5 cm lateral to this nodule is the smallest nodule measuring about 1.0 cm in diameter. The smallest nodule is located 0.2 cm from the superior. and 0.5 cm from the lateral margin. parenchyma is composed of yellow lobulated adipose tissue.. The remaining portion of the breast sections of the specimen are submitted as follows. Representative Summary of Sections:  medial margin LM lateral margin T1 largest centrally located nodule. T2 larger of the smaller nodules located lateral to the main mass. T3 the smallest nodule R representative sections of the remaining breast tissue. Summary of Sections: Part 1: SP: Sentinel node #1 level one right axilla (fs) ( Block Sect. Site pCs 1 Fsc 1 Part 2:  SP: Sentinel node #2, level one right axilla (fs) Block Sect. site 1 PCs FsC 1 Part 3: SP: Wide excision of tumor right breast 10:00 Block Sect. Site 3 PCs LM 2 9 MM 6 3 3 Procedures/Addenda: Addendum ** Continued on next page *.
+
+--- Page 4 ---
+Date Ordered: Status: Page8r Date Complete: Siamed Out Date Reported: By: Addendum Diagnosis ADDENDUM SENTINEL LYMPH NODE, RIGHT AXILLA PART #1, AND 2. PART #1. METASTATIC CARCINOMA IN THE FORM OF MICROSCOPIC CLUSTERS AND SINGLE CELLS MEASURING LESS THAN 2MM (MICROMETASTASIS). IS IDENTIFIED ON CYTOKERATIN IMMUNOHISTOCHEMICAL STAINS ONLY. PART #2. ONE ISOLATED CYTOKERATIN-POSITIVE CELL IS PRESENT. IDENTIFIED ON THE H&E STAINED SECTIONS. THESE CELLS ARE NOT Addendum Date Ordered: Status: Date Complete: Sirmed Mt Date Reported: By: Addendum Diagnosis ADDENDUM SITE:  RIGHT BREAST ER: >95% OF NUCLEAR STAINING WITH STRONG INTENSITY. PR: 40% OF NUCLEAR STAINING WITH MODERATE INTENSITY. HER2/NEU (HERCEPTEST) : NEGATIVE (STAINING INTENSITY OF O).) CONTROLS ARE SATISFACTORY. M.D. Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the. tissue sample examined at the time of the intraoperative ** Continued on next page **.
+
+--- Page 5 ---
+consultation 1 FROZEN SECTION DIAGNOSIS:  NO TUMOR IDENTIFIED. PERMANENT DIAGNOSIS: SAME. a) : FROZEN SECTION DIAGNOSIS: NO TUMOR IDENTIFIED. PERMANENT DIAGNOSIS: SAME. End of Report
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diff --git a/output/text/ae31549f-3777-4fef-ac66-e002b086d478.txt b/output/text/ae31549f-3777-4fef-ac66-e002b086d478.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0010dff55d7cecc306072698731a3e224538a3f8
--- /dev/null
+++ b/output/text/ae31549f-3777-4fef-ac66-e002b086d478.txt
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+Patient history: CHIEF COMPLAINT/PRE-OP/POST-OP DIAGNOSIS: 1.2-cm mass uppet inner quadrant left breast, core blopsy invasive ductal carcinoma. LMP DATE: Not provided. UUID:801A4E2F-E26E-424F-BF42-CD0D9CD62BCE PROCEDURE: Left segmental mastectomy, sentinel lymph node biopsy.. TCGA-BH-A0W3-01A-PR Redacted SPECIFIC CLINICAL QUESTION: Not provided. Outside tissue Diagnosis: Ng.  +- PRIOR MALIGNANCy: No. CHEMORADIATION THERAPY: No. Other Diseases: No. ADDENDA: Addendum Immunostains for HER-2/neu were performed on block 1B. HER2 Imnunohrsrochexistry: Using appropriate formalin fixed (8 - 96 hours), controls and tissue test block, 4B5 antibody clone is used as part of FDA approved Pathway on the and interpreted as follows: 2+ A weak to moderate complete membrane staining is (Equivocal) observed in more than 10s of the tumor cells) NOTE: Her-2/Neu FisH was ordered and will be subseguently reported.. CASE SYNOPSIS:  SyNOPTiC - PRIMARy InVASIVE CARCInOMA OF BREAST LATERALITy: Lett.. PROCEDURE:  Segmental LOCATIOn: Upper inner quadrant Size of tumor:  Maximum dimension invasive component: 15 mm  MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: No TumoR type (invasive component): Ductal adenocarcinoma, NOS NOTTINGHAM SCORE: Nuclear grade: 2 Tubule formation: 3 Mitotic activity score: 1 Total Nottingham score: 6 Nottingham grade (1, 2, 3): 2 ANGIOLYMPHATIC INVASION: No DeRmal Lymphatic invasiOn:  Not appllcable 1cs-0 -3 CALCIFICATIOn: No Tumor type, in situ: Cribriform Micropapilary carcmomu,injilt^aHng duct Nos SURGICAL MArGINS iNVOLVED BY INVASIvE COMpONenT: 8.50u/3  NO Lymph nOdes eXAmIneD: MEtHOD(S) OF LymPH NODE EXAMINATiON: 4 Sifu; briot,Nos c50.9 H/E stain SENTINEL NODE METASTASIS: Yes t stage, pathologic: pT1c N STAgE, PATHOLOGIC: pN1a M stage: Not applicable Estrogen receptors: positive, H-score: 300 PROgESTEROnE RECEPTORS: positive, H-score: 225 HER2/NEU: 2+ INTERPRETATION nuc ish(D17Z1,ERBB2)x2~6[80]  No amplification of the HER-2/NEU gene was seen by interphase FISH analysis. RESULTS: Fiuorescence in situ hybridization (FiSH) analysis was oerformed on a formalin-fixed Block 1B (Left segmental mastectomy 10:00) using the DNA probe for the HER-2/NEU gene'  An adequate number of invasive tumor cells were present and evaluated by four independent observers. The ratio of HtR-2/NEU signals (ERBB2) to chromosome 17 centromere. signals 1 . was determined to be 1.69. A ratio of greater than 2.2 is considered to be amplified with ratios of 1.80 to 2.20 in. the equivocal range; therefore, this speclmen is not amplified. The average number of HER-2/NEU signals per cell was 4.10. The average number of signals for the chromosome 17 centromere was 2.43. Many af the cells exhibited 3 or more signals for  both the HER-2/NEU gene and for the chromosome 17 centromere. This may be indicative of either polyploidy or aneuploidy tor chromosome 17." Concurrent positive and negative controi specimens showed the expected results. This FISH test is perforned using a modification of the Vysis FDA approved PathVysion HER-2 DNA Probe Kit (1:2 LSI HER-2/neu / CEP17 orobe : T-denhyb-2 buffer). This FisH test was developed and Its performance determined by the  Pursuant to the requirements of CLIA '88, this laboratory has established and vennea tne test's accuracy and precision. Criteria
+
+--- Page 2 ---
+FINAL DIAGNOSIS: PART 1: BREAST, LEfT, SEGmenTAl mASTeCTOmY AT 10:00-  INVASIVE DUCTAL CARCINOMA, NOTTINGHAM GRADE 2 (TUBULAR FORMATION 3, NUCLEAR GRADE 2, MITOTIC ACTIVITY 1; TOTAL SCORE 6/9). B.  THE INVASIVE TUMOR MEASURES 1.5 CM iN LARGEST DIMENSION (GROSS MEASUREMENT). c.  DUCTAL CARCINOMA IN SITU (DCIS), MICROPAPILLARY AND CRIBRIFORM PAT'TERNS, NUCLEAR GRADE 2. D. DCIS ACCOUNTS FOR 6% OF TOTAL TUMOR VOLUME, ADMIXED WITH OR CLOSE TO INVASIVE COMPONENT. E.  INVASIVE TUMOR IS 2.5 MM FROM ANTERIOR MARGiN AND 4 MM FROM POSTERIOR MARGIN; DCIS IS LESS THAN 0.2 MM FROM THE ANTERIOR MARGIN. F.  NO LYMPHOVASCULAR INVASION IDENTIFIED. G. ATYPICAL DUCTAL HYPERPLASIA. H.  NON-NEOPLASTIC BREAST TISSUE SHOWING PAPILLOMA, FIBROCYSTIC CHANGE AND DUCTAL EPITHELIAL HYPERPLASIA. BIOPSY SITE CHANGES. J. TUMOR IS POSITIVE FOR ER AND PR, HER-2/NEU SCORE 2+ (e PART 2: ADDITIONAL ANTERIOR MARGIN, NEW ANTERIOR MARGIN, EXCISION -- BENIGN BREAST FIBROADIPOSE TISSUE. PART 3: LEFT AXILLARY SENTiNEL LYMPH NODE #1, BIOPSY  A.  ONE OF TWO (1/2) LYMPH NODES, POSITIVE fOR METASTATIC CARCINOMA (SEE COMMENT). B.  THe Tumor MeasuReS 1 CM. PART 4: LEFT SENTINEL LYMPH NODE #2, BiOPSY -- ONE LYMPH NODE NEGATIVE FOR METASTATIC CARCINOMA (0/1). PARt 5: LEft SEnTInel Lymph nODE #3, bIOpSy - ONE LYMPH NODE, NEGATIVE FOR METASTATIC CARCINOMA (O/1).
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diff --git a/output/text/ae5fd4af-613b-41e6-bf1e-771f6a3f3d90.txt b/output/text/ae5fd4af-613b-41e6-bf1e-771f6a3f3d90.txt
new file mode 100644
index 0000000000000000000000000000000000000000..90d3cb57aae8e497f6372e46e8cc84acfe4c23ea
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+--- Page 1 ---
+UUID:A85A9598-F18C-43D3-888F-770DA2189462 TCGA-AN-A0XL-01A-PR Redacted TSS Patient ID: Case #: : DOB: Sex: Female Ethnicity (Race): Cancer Sample Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma Date of Procurement Anatomic Site: Breast Tumor location: Primary Tissue Specification: Tumor Specinen Matrix: Tissue Specimen Format: OCT Container: block Type of Procurenent: surgery Grade: 2 TStage: 2 N Stage:0 M Stage: 0 Treatment: none Treatment Details: n/a Normal Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw Matrix: Blood Specimen Format: frozen Container: tube Date of Procurement: 1cs-0-3 carcioma, inifiHnufhy duct; No5 85oc|3 Sit: brust, Nos C50.9 10/211 J-Jo/a+f?
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diff --git a/output/text/ae62a534-0d55-4e6d-8093-28c827cd7530.txt b/output/text/ae62a534-0d55-4e6d-8093-28c827cd7530.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8cced3fd64e33fe769b41d98c9f0bcd82decbf27
--- /dev/null
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+
+--- Page 1 ---
+UUID:8CC70CDC-01EC-4E2B-84C1-F1C946602CCE Redacted TCGA-AN-A0FZ-01A-PR TSS Patient ID: Case #: DOB: Sex: Female Ethnicity (Race) Cancer Sample Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma Date of Procurement: Anatomic Site: Left Breast Tumor location: Primary. Tissue Specification: Tumor Specimen Matrix: Tissue Specimen Format: Frozen Container: cryomold Type of Procurement: Radical mastectomy Grade: 2 T Stage: 2 N Stage: 2 M Stage: 0 Treatment: none. Treatment Details: n/a Normal Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw Matrix: Blood Specimen Format: frozen Container: tube. Date of Procurement: 1cs-0-3 carCiomn lnfiPtnaHny ouct Nos 85vo/3 Sih: brast, Nos c5o.9 HIPAA Dual/Syn ase is cuc  10/a/i
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diff --git a/output/text/aea98609-3515-4e0c-bb6f-fcb8bdad635c.txt b/output/text/aea98609-3515-4e0c-bb6f-fcb8bdad635c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3f19a996de3e804bb350b992521bdb01c99000c9
--- /dev/null
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+
+--- Page 1 ---
+1cs-0 - 3 UUID:6535D911-D718-4794-905E-6E06553464FF Redacted c artnink,iifi1trsHng duct N0s 85oo/3 Sit bresst Nus C50.9 Breast, left, modified radical mastectomy: Infiltrating ductal carcinoma, Nottingham grade II (of III), forming a mass (2.3 x 2.1 x 1.7 cm) located in the superior/central aspect of the breast [AJCC pT2] Ductal carcinoma in situ, intermediate nuclear grade, comprises approximately 5-25% of the tumor volume. Angiolymphatic invasion is present. The non-neoplastic breast parenchyma shows nonproliferative fibrocystic changes. The tumor does not involve the nipple, overlying skin, or underlying chest wall. All surgical resection margins, after re-excision of the anterior/superior margin, are negative for tumor (minimum tumor free margin, 0.7 cm, anterior/superior margin). The deep margin is negative for tumor (free by 0.8 cm). Multiple (22) left mid/low axillary lymph nodes are negative for metastatic carcinoma. Lymph nodes, left high axillary, excision: Multiple (3) left high axillary lymph nodes are negative for tumor. Lymph node, left axillary sentinel, excision: A single left axillary sentinel lymph node is positive for metastatic adenocarcinoma with one metastasis measuring 2.5 x 2.5 x 1.3 cm [AJCC pN1]. Extranodal extension is not present. Blue dye is not identified.
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diff --git a/output/text/aeac7257-5f42-4882-9ab4-47012279b458.txt b/output/text/aeac7257-5f42-4882-9ab4-47012279b458.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a162d7d03c52989cc9b7498b1afbfc27a12a2465
--- /dev/null
+++ b/output/text/aeac7257-5f42-4882-9ab4-47012279b458.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Received: Status: Specimen: Spec Type: SURGICAL P Subm Drt 1cs-0-3 Carciioma, lfiltratmg Ouctel, Nos 85o0/3 RIGHT BREAST CANCER INVASIVE C5o 9 Site : sreest, Nos 1/a7/ DATE: DOCTOR(S) : BEATERAE RIMPLE MASTECTOMY SENPENBON UUID: 383EC600-FBF3-4F91-8FAC-41E3DDE6589E LT BREAST MASTECTOMY TCGA-A2-A0T7-01A-PR Redacted A. B. RT BREAST SENTINEL NODE #1 C. RT BREAST SENTINEL NODE #2S D. RT BREAST MASTECTOMY RECEIVED IN FOUR PARTS. PART A: RECEIVED FRESH LABELED LEFT BREAST MASTECTOMY, STITCH AT 12OO IS A SIMPLE MASTECTOMY SPECIMEN MEASURING 15 X 14.5 X 4 CM IN GREASTEST DIMENSIONS. THE NIPPLE IS UNREMARKABLE WITHIN A 6.3 X 3.6 CM SKIN ELLIPSE. THE SUPERFICIAL MARGIN IS MARKED BLUE WHILE THE DEEP ASPECT IS MARKED WITH BLACK INK. SECTIONING REVEALS CENTRAL FIBROSIS WITH MULTIPLE CYSTIC AREAS CONTAINING GREY MUCINOUS FLUID. THIS AREA IS MEASURES 1O.5 X 9 X 3 CM AND IS SURROUNDED BY GROSSLY UNREMARKABLE YELLOW FATTY TISSUE. REPRESENTATIVE SECTIONS ARE SUBMITTED AS FOLLOWS: A1-NIPPLE; A2-CENTRAL DEEP MARGIN; A3-4 UPPER OUTER QUADRANT; A5-6 UPPER INNER QUADRANT; A7-8 LOWER INNER QUADRANT AND A9-1O-LOWER OUTER QUADRANT. PART B: RECEIVED FRESH LABELED SENTINEL NODE #1 HOT AND BLUE IS AN OVOID FRAGMENT OF BLUE COLORED TISSUE AND SURROUNDING YELLOW FAT MEASURING 2 X 1 X 1 CM. SECTIONING REVEALS A GROSSLY UNREMARKABLE BLUE DYED NODE MEASURING 1.7 CM IN GREATEST DIMENSION. A PORTION IS TAKEN PER PROTOCOL AND THE REMAINDER IS SUBMITTED LABELED B. PART C: RECEIVED FRESH LABELED SENTINEL NODE #2 HOT IS AN OVOID PORTION OF YELLOW FATTY TISSUE MEASURING 2 X 1 X 1 CM. SECTIONING REVEALS UNREMARKABLE NODAL TISSUE SUBMITTED ENTIRELY LABELED C. PART D: RECEIVED FRESH LABELED RIGHT BREAST MASTECTOMY,S STITCH AT 12 O'CLOCK IS A SIMPLE MASTECTOMY SPECIMEN MEASURING 17 X 15 X 5.0 CM. THE NIPPLE IS GROSSLY UNREMARKABLE WITHIN A 6 X 3 CM SKIN ELLIPSE. THE SUPERFICIAL ASPECT IS MARKED IN BLUE INK.  THE DEEP MARGIN IS MARKED IN BLACK INK. SECTIONING REVEALS A FIRM FIBROUS NODULE IN THE UPPER INNER QUADRANT MEASURING 2.5 X 1.5 X 1.5 CM. THE LESION GROSSLY EXTENDS TO WITHIN O.8 CM OF THE MOST MEDIAL MARGIN AND IS 0.7 CM FROM BOTH THE SUPERFICIAL AND DEEP MARGINS.  THE CENTRAL PORTION OF THE BREAST CONSISTS OF DENSE FIBROUS TISSUE WITH NUMEROUS CYSTIC AREAS AND THIS SURROUNDED BY BLAND YELLOW FATTY TISSUE.  THE CENTRAL AREA MEASURES 13 X 10.5 X 3.0 CM.
+
+--- Page 2 ---
+Received: atus: Specimen: Spec Type: SURGICAL P Subm Dr: (Continued) ADDITIONALLY LOOSE WITHIN THE CONTAINER ARE TWO FRAGMENTS OF GROSSLY UNREMARKABLE FATTY TISSUE TOGETHER MEASURING 7.5 X 5.7 X 2.0 CM. NO SECTIONS ARE SUBMITTED. D1--NIPPLE AND ADJACENT SKIN (MIRROR IMAGE TO RESEARCH), D2-3--FULL CROSS SECTION OF LESIONAL AREA, D4-5--FULL CROSS SECTION TO LESIONAL AREA. NOTE D2 THROUGH D5 MIRROR IMAGE TO TISSUE PROTOCOL, D5--SECTION OF LESION AND MOST MEDIAL MARGIN, D7--TUMOR (MIRROR IMAGE TO PROTOCOL), D8--UPPER INNER QUADRANT IMMEDIATELY ADJACENT TO TUMOR; D9--UPPER OUTER QUADRANT 7 CM FROM TUMOR, D1O--LOWER OUTER QUADRANT 7 CM FROM TUMOR, D11--LOWER INNER QUADRANT 4 CM FROM TUMOR. PROcEDURES : 88307/4, IMMUNOPEROXIDAS/2, A BLK/10, BBX X6, CBX X6, D BLK/11 FCc PART A LEFT BREAST, SIMPLE MASTECTOMY: DIFFUSE FIBROCYSTIC CHANGES WITH ADENOSIS AND FOCALLY MARKED NON-ATYPICAL INTRADUCTAL EPITHELIAL Adunasns,nos HYPERPLASIA PRESENT. NO EVIDENCE OF MALIGNANCY. nona$yp 1d#-2 PART B RIGHT AXILLARY SENTINEL LYMPH NODE #1: REACTIVE LYMPH NODE WITH NO EVIDENCE OF METASTATIC DISEASE, SUPPORTED BY NEGATIVE CYTOKERATIN IMMUNOHISTOCHEMICAL STAINING. PART C RIGHT AXILLARY SENTINEL LYMPH NODE #2: ISOLATED TUMOR CELL Isol. cell CLUSTER, O.1 MM, IDENTIFIED IN A CAPSULAR LYMPHATIC SPACE. THE LESION IS .Imm VISIBLE ON ROUTINE H&E STAINING, CONFIRMED BY POSITIVE CYTOKERATIN IMMUNOHISTOCHEMICAL STAINING. THE FOCUS DISAPPEARS ON DEEPER SECTIONING INTO THE TISSUE BLOCK. 1DC q.6cm PART D RIGHT SIMPLE MASTECTOMY: MODERATELY DIFFERENTIATED INFILTRATING 273/3 DUCTAL CARCINOMA, NUCLEAR GRADE III/III WITH A HIGH MITOTIC INDEX WITH INVASIVE CARCINOMA SPANNING A MICROSCOPIC DISTANCE OF 2.6 CM. MINOR FOCI OF MICROPAPILLARY-TYPE DUCTAL CARCINOMA IN SITU ARE PRESENT, BUT OVER 90t OF THE TUMOR IS INVASIVE.  THE TUMOR IS LOCATED IN THE UPPER INNER 5r.2. QUADRANT OF THE BREAST (2 O'CLOCK POSITION) WITH A MICROSCOPIC TENDRIL OF 0% TUMOR EXTENDING TO THE SUPERFICIAL MARGIN (SLIDE D3). THE MEDIAL MARGIN Dcis IS FREE OF TUMOR BY A DISTANCE OF 5 MM AND THE DEEP MARGIN BY miuro pap APPROXIMATELY 1 CM. REPRESENTATIVE SECTIONS OF BREAST TISSUE AWAY FROM THE PRIMARY TUMOR SITE SHOW PROLIFERATIVE FIBROCYSTIC CHANGES WITH AREAS OF MARKED INTRADUCTAL EPITHELIAL HYPERPLASIA PRESENT, BUT NO ADDITIONAL AREAS OF MALIGNANCY.  SF margew-focod Fcc 1Dh-3
+
+--- Page 3 ---
+(Contlauad) Specimen: Received: Status: Spec Type: SURGICAL p Subm Dr: 1 Signed (prelim.) (signature on file)
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diff --git a/output/text/aebab2e3-a0b8-4482-ae06-31f8109fbfe5.txt b/output/text/aebab2e3-a0b8-4482-ae06-31f8109fbfe5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..483401a2a56f8b09021667da661e9fd6cab0f7a1
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+page 1 / 1 TCGA-D5-6532 Examination: Histopathological examination Cost of diagnostic procedure.  Material: 1. Multiple organ resection -- sigmoid colon Physician in charge! Material collected on: Material received on: Expected time of examination:. Clinical diagnosis: Cancer of the sigmoid colon. Hist. Pat adenocarcinoma invasivum. Examination performed on Macroscopic description: 21 cm length of the large intestine with fat tissue of 22 x 10 x 5 cm. Ulcerous tumour sized 8 x 5 x 1.5 cm in the mucosa. The lesion surrounds 55% of the intestine circumference, narrowing its lumen; is located 11 cm from one of the cut ends and 2 cm from the opposite one. The lesion macroscopically invades through the periintestinal tissue. Minimum side margin is 0.1 cm. Microscopic description: Adenocarcinoma tubulare (G2). Infiltratio carcinomatosa tunicae muscularis priopriae et telae adiposae pericolicae. Incision lines free of neoplastic lesions.. Lymphonodulitis reactiva (No X). Final diagnosis after immunohistochemical tests No. are performed. Compliance validated by: Examination performed on:. Histopathological diagnosis: Adenocarcinoma tubulare coli. Tubular adenocarcinoma of the colon. (G2, Dukes B, Astler - Coller B2, pT3, pN0). Compliance validated by:
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diff --git a/output/text/af418d22-7db8-4771-9c14-ab610e1c2fac.txt b/output/text/af418d22-7db8-4771-9c14-ab610e1c2fac.txt
new file mode 100644
index 0000000000000000000000000000000000000000..22fe0a8fe8be498048052c716c8eb1ec2b3fd1e6
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+CGA-A6-4107 SPECIMEN Right colon CLINICAL NOTES PRE-OP DIAGNosIS: Right colon cancer. GROSS DESCRIPTION Received fresh labeled "right colon" is a previously. unopened 17 cm. segment of proximal right colon with. attached 13.5 cm. of distal ileum surfaced by smooth to slightly scabrous tan-pink serosa with a copious amount of attached mesocolon and mesentery. A 4.7 cm. unremarkable appendix ranging from 0.5 to 0.8 cm. in diameter is present. The proximal and distal margins measure 4.0 and 6.5 cm. in circumference respectively. On opening, there is a circumferential, 7.8 x 4.6 cm. lobulated soft tan-pink lesion 8 cm. distal to the ileocecal valve. A portion of tumor and a portion of normal are submitted for tissue procurement as requested. On sectioning, the tumor has a maximal thickness of 1.4 cm. and appears to grossly extend through the muscularis focally. The tumor is greater than 3 cm. from the inked free serosal. surface. The ileal mucosa is finely nodular tan-pink with irregular folds and the wall averages 0.5 cm. in thickness. The uninvolved colonic mucosa is unremarkable glistening tan-pink with irregular folds and the wall averages 0.5 cm. in thickness as well. Multiple soft to slightly rubbery tan pink-red tissues in keeping with lymph nodes measuring up to 1.4 cm. in greatest dimension are recovered from the attached mesocolon and mesentery. Representative sections are submitted in 17 blocks as labeled. Rs-17 BLOcK suMMARy: 1 - Proximal and distal margins; 2-5 - central tumor; 6 - closest inked radial serosal surface subjacent to tumor; 7 - Icv; 8 - random ileum and colon; 9 - appendix; 10-12 - eight whole lymph nodes per cassette; 13, 14 - six whole lymph nodes per cassette; 15, 16 - one trisected lymph node per cassette; 17 - one
+
+--- Page 2 ---
+GROSS DESCRIPTION bisected lymph node. MICROSCOPIC DESCRIPTION A summary of the microscopic findings for this right colon resection is in the template below. Histologic type: Invasive adenocarcinoma. Histologic grade: Moderately differentiated. Primary tumor (pT): Tumor invades through the muscularis propria into the superficial pericolonic fat (pT3). Proximal margin: Negative for tumor. Distal margin: Negative for tumor. Circumferential (radial) margin: Negative for tumor. Distance of tumor from closest margin: 19 cm from distal margin. Vascular invasion: Not identified. Regional lymph nodes (pN): Metastatic adenocarcinoma is identified in 2/28 lymph nodes (pN1b).. Non-lymph node pericolonic tumor: Not identified. Distant metastasis (pm): Can not evaluate pMx. Other findings: The appendix demonstrates endometriosis. COMMENT : MSI testing was requested by the surgeon. Block 2 has been sent to. for msr testing and that report will be sent to office. 5 DIAGNOSIS A. Colon, right, ileocolectomy:. Invasive moderately differentiated adenocarcinoma, invasive through muscularis propria into fat (pT3). DIAGNOSIS 2of 28 lymph nodes positive for metastatic adenocarcinoma (pN1b). Resection margins are negative for carcinoma. Appendix with endometriosis.. End Of Report..
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diff --git a/output/text/af6e4748-46f9-45ea-a59e-de1f8325639f.txt b/output/text/af6e4748-46f9-45ea-a59e-de1f8325639f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..403faeb871b4f3e2a5fcda36475b48156343bab1
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+--- Page 1 ---
+LCD-O-3 leeenora),renaI eeQS Skronyphel type 8317|3 SURGICAL PATHOLOGY Case Number : Ce4.9 q/13 W87 Diagnosis: A: Soft tissue, small bowel nodule, biopsy. - Bland spindle cell proliferation, consistent with mesenteric fibromatosis - See comment B: Small bowel, colectomy - Segment of small bowel with bland mesenteric spindle cell proliferation, consistent with mesenteric fibromatosis, 5.1 cm in greatest diameter - Fibromatosis extends into muscularis propria of small bowel and into surrounding fibroadipose tissue'of mesentery and is <l mm from the cauterized margin - Bowel margins appear histologically viable and are negative for fibromatosis with distal small bowel margin (B3) demonstrating mild acute serositis. - Three lymph nodes, negative for malignancy (0/3) - See comment C: Gallbladder, cholecystectomy - Mild chronic cholecystitis Redacted - Negative for fibromatosis D: Kidney, right, partial nephrectomy Procedure: Partial nephrectomy Laterality: Unilateral, right side. Histologic tumor type/subtype: Renal cell carcinoma, chromophobe subtype; see comment Sarcomatoid features: None identified. Histologic grade (if applicable): Fuhrman grade 2 of 4 Tumor size (greatest dimension): 4.6 cm. Tumor focality: Unifocal Extent of tumor invasion (if present specify if macroscopic or microscopic) : Capsular invasion/perirenal adipose tissue: Negative for
+
+--- Page 2 ---
+malignancy Gerota' s fascia: Negative for malignancy Renal sinus: Negative for malignancy Venous (large vessel): Not identified Lymphatic (small vessel): Not identified Histologic assessment of surgical margins: Renal parenchymal margin (partial nephrectomy only): Negative for malignancy; tumor is 5 mm from the parenchymal margin Renal capsular margin (partial nephrectomy only): Negative for malignancy Paranephric adipose tissue margin (partial nephrectomy. only): Negative for malignancy; tumor is 2 mm from the perinephric adipose tissue margin. Adrenal gland: Not received Lymph nodes: Not received Pathologic findings in non-neoplastic kidney: - No fibromatosis identified - Patchy minimal glomerular sclerosis AJCc Staging: pT1b pNX This staging information is based on information available at the time of this report, and is subject to change pending clinical review and additional information. Comment: Immunohistochemical stains are performed on block B4,a representative section of the mesenteric mass, and demonstrate the mass is negative for pancytokeratin, cdli7, s1o0, and muscle specific actin with slight focal staining for desmin and blood vessels outlined by cD34. Note is made of the patient's and Dr. prior pathology and the pathology referral to. opinion. The current specimen demonstrates prominent vasculature and focal fascicular architecture, consistent with mesenteric fibromatosis. Dr. notes in his comments on the prior pathology that a subset of fibromatoses can be beta catenin negative (which was the case with the patient's prior pathology). Given the overall appearance of the tumor and immunohistochemical profile, we favor mesenteric fibromatosis. Dr. has reviewed select slides from specimen B along with the immunohistochemical stains and concurs with the diagnosis of
+
+--- Page 3 ---
+mesenteric fibromatosis. Immunohistochemical stains are performed on block D1 and demonstrate the renal tumor is positive for cDli7, patchily positive for cdio and negative for racemase, Rcc, and vimentin, consistent with the chromophobe variant of renal cell carcinoma. Intraoperative Consult Diagnosis: An intraoperative consultation is requested by Dr. FsAl: Small bowel nodule, biopsy - Blind spindle cell proliferation, defer subclassification to final with IHC. - No overt evidence of sarcoma or carcinoma identified Dr. and, PA at. Frozen Section Pathologist: Clinical History: -year-old male with mesenteric mass; core biopsy diagnosis of. blind spindle cells and chromophobe renal cell carcinoma. (see surgical pathology case: ). Gross Description:. Specimen A is labeled "small bowel nodule, biopsy" and is a 2.2. x 0.5 x 0.4 cm wedge of serosa with 0.5 cm nodule. A 2.2 cm staple line is removed and inked blue. The nodule is bisected and submitted entirely in FsAl, Specimen B is labeled "small bowel tumor" and the requisition states "short stitch is proximal, small bowel margin, long stitch is duodenal margin" and holds a tortuous segment of small. bowel approximately 45 cm long with an open circumference of 4.5 cm. The specimen is received oriented as stated above. Within the mesentery there is a 5.1 x 4.6 x 3.5 cm firm mass. The fat overlying the mass at one edge is roughened, focally cauterized and inked green. Embedded within this fat and marked by the surgeon as the duodenal margin is a 2.5 cm long staple line which is removed to reveal small bowel mucosa. This margin is submitted as an en face section. Sectioning through the mass reveals that it has a white whorled firm cut surface. The mass comes to within 1 cm of the green inked roughened mesenteric surface, is <0.6 cm from the stapled duodenal margin, and is >5 cm from the proximal and distal small bowel mucosal margins.
+
+--- Page 4 ---
+The mass is centered within the mesenteric fat and does not involve the adjacent segment of small bowel. No additional abnormalities are noted. The small bowel serosa is tan/pink and glistening. Opening reveals tan glistening folded unremarkable mucosa. No lesions or masses are noted. A portion of the mass is submitted to tissue procurement.. Block Summary: B1 - Stitched duodenal margin, en face. B2 - Proximal small bowel margin, en face. B3 - Distal small bowel margin, en face B4-B5 - Mass with respect to duodenal mucosa, green inked roughened surface, perpendicular B6-b9 - Additional sections of mass. B10 - Three lymph nodes Tissue remains in formalin. Specimen c is received in one appropriately labeled container. Previously opened or disrupted: No Measurements: 8.6 x 1.5 x 0.5 cm External surface: Purple/smooth Luminal contents: Red liquid bile. Stones present: No Mucosa: Red and velvety Wall thickness: 0.1 cm Other comments:. Block #: c1 - Cystic duct margin and representative sections Tissue remains in formalin. Specimen D is labeled "kidney tumor right partial nephrectomy" and holds a 73.4 gram 6.2 x 5.5 x 4.2 cm partial nephrectomy. The parenchymal margin is red/brown and inked blue. The capsule is red/brown, smooth and inked black. Within the specimen there is a 4.6 x 4.2 x 4.0 cm tan soft well-circumscribed bass that bulges on cut section. The mass comes to within 0.4 cm of the blue inked parenchymal margin and abuts the capsule but does not extend through it. A portion of the mass and normal is submitted. to tissue procurement. The adjacent uninvolved kidney parenchyma. is red/brown and unremarkable. Block Summary:. D1-D2 - Mass with respect to blue inked parenchymal margin, perpendicular D3-D4 - Mass with respect to black inked capsule D5 - Kidney parenchyma away from mass Jw 7/30|i3 Tissue remains in formalin.
\ No newline at end of file
diff --git a/output/text/af8ee5f8-f383-4246-b7d5-d54c83d74ce8.txt b/output/text/af8ee5f8-f383-4246-b7d5-d54c83d74ce8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..21487e49c32c9d5c714e88db13b9545541e8add6
--- /dev/null
+++ b/output/text/af8ee5f8-f383-4246-b7d5-d54c83d74ce8.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Sample Number Sample Type  TUMOUR  Diagnosis  Renal cell carcinoma, chromophil (papillary) type  Year of Sample Collection. Age at Sample Collection (yrs) Days to Procedure Date  Days to Diagnosis  Type of Procedure RESECT  Site of Tissue/Primary (Histology)  Right kidney  Tumour Size (cm) 6.5  Histology  Renal cell carcinoma, chromophil (papillary) type  Grade/Differentiation III  Pathological T T1b  Pathological N NX Clinical M  MO Histology Comments  Sample Number Sample Type BUFFY  Year of Sample Collection.  Age at Sample Collection (yrs)  Days to Procedure Date  Days to Diagnosis UUID:959830C4-A6B8-48B6-8202-D052E922CADE TCGA-HE-A5N-01A-PR Redacted zcD-o-3 Corcinms ,papillary reual cell 826d3 Si+c Kidney NoS Co4.9 9w xIu3 hw o/r/13
\ No newline at end of file
diff --git a/output/text/af964f36-7f1e-4522-bcc0-8e1504e9c9c3.txt b/output/text/af964f36-7f1e-4522-bcc0-8e1504e9c9c3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a0d92f0da66a307a6219eea0f1e975c4a21c5a99
--- /dev/null
+++ b/output/text/af964f36-7f1e-4522-bcc0-8e1504e9c9c3.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Surgical Pathology Histopathological Examination Pre-Op Diagnosis : Lap Rt Colon Resection Order Physician Specimens 5lon Frozen Diagnosis Report : GROSS EXAMINATION: The specimen is received fresh in a container labeled with. the name of the patient and identified as colon segment, right colon. Length of Terminal Ileum: 10.5 cm Circumference of Terminal Ileum: 4.9 cm Length of Colon: 36.5 cm Circumference of Colon: 9 cm Margins: Stapled Serosa: A 2.5 x 1.8 cm puckered area in the ascending colon located 12 cm from the distal margin. Mass #1: Size: 6.4 x 4.5 x 1.2 cm Type: Infiltrative with raised edges Region: Cecum Distance from proximal margin: 10.5 cm Circumference:* 50% Depth of Invasion: 0.6 cm Distance from Radial Margin: 2.2 cm Mass #2: Size: 7.8 x 5 x 1.1 cm Type: Infiltrative with raised edges Reqion:  Ascending colon Distance from distal margin: 9.7 cm Circumference: 90% Depth of Invasion:  0.3 cm Distance from Radial Margin: 0.9 cm There is a 1.2 cm pink polyp located 1.7 cm distal to the. cecal mass and a 0.4 cm' tan polyp located 1.6 cm from the ascending mass. Appendix: Absent. Block Summary: 1, cecal mass and radial margin; 2-4, THIS CONFIDENTIAL AND PRIVILEGED DOCUMENT/INFORMATION IS PROTECTED BY FEDERAL AND STATE LAW. UNAUTHORIZED DISCLOSURE, DISSEMINATION OR DUPLICATION IS PROHIBITED Path # : Page 1 of 3 Visit # :
+
+--- Page 2 ---
+additional sections of cecal mass; ascending mass and radial margin; 6, ascending mass and serosa (black ink);. 7-8, additional sections of ascending mass; 9, proximal polyp; 10, distal polyp; 1l,. roxima nargin; 12, distal margin; 13-15, lymph nodes.. DIAGNOSIS BASED ON GROSS AND MICROSCOPIC EXAMINATION: Extended right hemicolectomy (36.5 cm):  Colonic adenocarcinoma, 6.4 cm, high-qrade, with extension through the muscularis propria (pT3) involving the cecum. (see summary template).  Colonic adenocarcinoma, 7.8 cm, low-grade, with extension through the muscularis propria (pT3) involving the ascending colon at the hepatic flexure(see summary template).  Lymphovascular invasion identified. - Tubular adenomas x 2. - Margins of resection are free of carcinoma.. [T-59600 M-81403 154.1 P3-44090] COLON AND RECTUM: ReseCtion Specimen: Terminal ileum, cecum, and ascending colon.. PROCEDuRE: Right hemicolectomy. SPECIMEN LENGTH: Terminal ileum: 4.9 cm Colon: 36.5 cm TumoR siTE: Cecum and hepatic flexure.. TUMOR SIZE: 6.4 cm and 7.8 cm MACROSCOPIC TUMOR PERFORATION: Not identified. HISTOLOGIC TYPE: Adenocarcinoma. HISTOLOGIC GRADE: High-grade (poorly differentiated) in cecum. Low-grade (well to moderately differentiated) at hepatic flexure. HISTOLOGIC FEATURES SUGGESTIVE OF MICROSATELLITE INSTABILITY: Intratumoral lymphocytic response: Mild to moderate. Peritumoral lymphocytic response: Mild to moderate. Tumor subtype and differentiation: High histologic grade (poorly differentiated). MICROsCOPIC TUMOR ExTENSION: Tumor invades through the muscularis propria into subserosal adipose tissue. MARGINS: Proximal, distal, and radial margins uninvolved by invasive carcinoma. closest margin: 0.9 cm (radial margin) at hepatic flexure mass. TREATMENT EFFECT: No prior treatment.. Lymph-VAscuLAR InVasIOn: Present. PERINEURAL INVASION: Not identified. TUMOR DEposITs: Not identified. PATHOLOGIC STAGING (pTNM): TNM Descriptors: m (multiple primary tumors). Primary Tumor (pT): pT3 (Tumor invades through the muscularis propria into peri colorectal tissues.. Regional Lymph Nodes (pN): pNlb (Metastases in 2-3. regional lymph nodes). THIS CONFIDENTIAL AND PRIVILEGED DOCUMENT/INFORMATION IS PROTECTED BY FEDERAL AND STATE LAW.  UNAUTHORIZED DISCLOSURE, DISSEMINATION OR DUPLICATION IS PROHIBITED Path #: Page 2 of 3 Visit #:
+
+--- Page 3 ---
+Number examined: 18 Number involved: 2 Distant Metastasis (pM): N/A ADDITIONAL PATHOLOGIC FINDINGS: AdenOmaS, x 2. pTNM SUMMARY: pT3N1b (both lesions) COMMENT : Intradepartmental consultation obtained. THIS CONFIDENTIAL AND PRIVILEGED DOCUMENT/INFORMATION IS PROTECTED BY FEDERAL AND STATE LAW. UNAUTHORIZED DISCLOSURE, DISSEMINATION OR DUPLICATION IS PROHIBITED Path # : Page 3 of 3 Visit  # :
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diff --git a/output/text/afaba581-f4ec-4d33-a98c-fc062c879625.txt b/output/text/afaba581-f4ec-4d33-a98c-fc062c879625.txt
new file mode 100644
index 0000000000000000000000000000000000000000..cad2e4d6c7d56cc085836382469176cec6724485
--- /dev/null
+++ b/output/text/afaba581-f4ec-4d33-a98c-fc062c879625.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+Inica! Case Report. (For Collection of Cancerous Tissue). Informed Consent I personally informed this natient that a specimen(s) would be collected to be used for research purposes. I reviewed the RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator. Signature Jate Clinical Information GENERALINFORMATIONWSAT Height Marital Status Race Temperature Gender Weigh Heart Rate PKR CHISTORYOFPRESENTILLNESSS Chief Complaints: Ahdooyuncl pcu n ) Ned bEood in te Symptoms: Weighf Wss Clinical Findings: Performance Scale (Karnofsky Score):  80-90 Symptomatic but Fully Ambulatory 60-70. Symptomatic, in bed less than 50% of day.  100 Asymptomatic  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden  20-30 Bed Ridden CURRENTMEDICATIONSRSS Dose Route Frequency Date (mm/dd/yyyy) Drug To To To To To
+
+--- Page 2 ---
+Diagnosis/Disease/Disorder/Injury Diagnosis Date Treatment Status SOCIALHISTORYS Occupation: Environmental Hazards: Smoking History Current Status TYPE Packs/day Duration When Quit Loaek[d cey] 20 (yrs) 2 omnths YES NO (yr) Alcohol Consumption0 Current Status TYPE Drinks/day Duration When Quit YES  NO (yrs) 2 omuths ay (yr Drug Use Current Statusd TYPE Frequency Duration When Quit  YES ENO (yrs) (yr) Relative Diagnosis Age of Diagnosis SLABDATA Test Result Date Test Result Date HIV Negative  Positive: CEA   Negative  Positive: Hep B  Negative CA 15-3   Negative  Positive:  Positive: Hep C Negative  Positive: CA 19-9   Negative  Positive: !/ PSA  Positive:   Negative  Positive: AFP  Negative Other: Other:  Negative  Positive:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+Study Results Date Ultrasound X-Ray CT Endoscopy MRI Biopsy CLINICALDIAGNOSISS Preoperative Clinical Diagnosis Location of Suspected Involved Lymph Nodes Location of Suspected Distant Metastasis Clinical Staging T3 Nc M O UA Stage: Treatment Information Procedure Date of Procedur. Cleetxms Primary Tumor Organ Detailed Location Size C0loD JpemR Liotr Sx S x 3 cm Extension of Tumor. Lymph Nodes Description Location of Lymph Nodes. # of Lymph Nodes. Palpable, Non-Dissected Lymph Nodes. Dissected Lymph Nodes Distant Metastasis Organ Detailed Location Size Surgica! Staging. Stage: 1 T 3 N o m NEOADJUVENT THERAPY (Chemo,Radiation Immuno, Hormonal,or Molecular) Dose Route Frequency Date (mm/dd/yyyy) Drug/Treatment To To / To / / To / To / 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by: Date ime1 Preserved by: Date ime Frozen Paraffin Biock  Blood/Serum/Plasma Slide Diseased  Normal Diseased Normal Diseased Normal Diseased Normal 2 2 Time to LN2 Time to Formalin Time to LN2 min 12 min min Primary Tumor Organ Size Extension of Tumor Distance to NAT cotem TemR 6 x S x3 cm 6 cm Lymph Nodes Location # Examined # Metastasized Distant Metastasis Organ Detailed Location Size Pathological Staging N o Mo pT 3 Stage: 1 Notes: fQcks ( M1, jU2,) 4
+
+--- Page 5 ---
+Microscopic Description Cell Distribution x Structural Pattern + Diffuse  Streaming Mosaic  Storiform Necrosis Fibrosis Lymphocytic Infiltration  Palisading Vascular Invasion  Cystic Degeneration Clusterized Bleeding Alveolar Formation  Myxoid Change Indian File  Psammoma/Calcification Squamous + - Adenomatous + Sarcomatous + Lymphomatous + - Squamoid Cell Glandular cell Round Cell Large Cell Spindle Cell Cell Stratification Fibroblast Small Cell  Keratin Secretion Osteoblast RS Cell/RS Like  Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell  Pear! Gland formation  Myoblast  Plasma Cell Well Moderate   Poor Cellular Differentiation: Nuclear Atypia: 0 1 II III Aniso Nucleosis  Hyperchromatism  Nucleolar Prominent  Multinucleated Giant Cell Mitotic Activity Nuclear Grade: Result Value Date Marker ER  Negative   Positive PR  Negative   Positive  Negative  Positive Her-2/neu B-Cell Marker  Negative   Positive T-Cell Marker  Negative   Positive Other:  Negative  Positive Other:   Negative   Positive Final Pathology Report Adenocercinume) of l/e colcm Histological Diagnosis: Grade: L uoceaate le sli eronti'dleel Comments:  Pathologist
+
+--- Page 6 ---
+OnSOLIdATED DIAgnOStIC pATHOLOgy fORm* Microscopic Appearance: 1.Histological pattern: CELL DISTRIBUTION Diffuse STRUCTURAL PATTERN Streaming + Mosaic X  Storiform Necrosis  Lymphocytic Infiltration Fibrosis K Palisading Vascular Invasion Clusterized Cystic Degeneration X Bleeding. Alveolar Formation  Myxoid Change Indian File Y Psammoma/Calcification 2. Cellular features: Squamous + Adenomatous +  Sarcomatous Squamoid Cell + Lymphomatous Glandular cell  Round Cell Large Cell Spindle Cell  Cell Stratification Fibroblast Keratin  Small Cell Secretion Osteoblast RS Cel/RS Like  Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell Pear!  Gland formation  Myoblast  Plasma Cell Otherwise Specified: 687 Dv70Z Dy 607 10eAexs 1OJ Da. 2.Cellular Differentiation: Well  Moderately Poor 3. Nuclear Atypia: Nuclear Appearance 0 III Aniso Nucleosis Hyperchromatism  Nucleolar Prominentd Multinucleated Giant Cel!  Mitotic Activity Nuclear Grade Histological Diagnosis:  Adesss ta Rth Aor0 M Ns : lhponst Lyonsbodeuiibs Comments: PATHOLOGIST STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
\ No newline at end of file
diff --git a/output/text/afc4d9dd-38aa-4c0e-ad93-040e66d2cf38.txt b/output/text/afc4d9dd-38aa-4c0e-ad93-040e66d2cf38.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ecccbe60bf0d6ff0626e84bc16212874ff631f14
--- /dev/null
+++ b/output/text/afc4d9dd-38aa-4c0e-ad93-040e66d2cf38.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+UUID:593AF241-8F84-48A0-8878-7C1CE72A4603 Redacted TCGA-A2-A3KC-01A-PR Chiet of Pathology Phone Fax Patient: Specimen: Received: 'tatus: SOUT Req#: Spec Type: SURGICAL P Subm Dr: GROSS DESCRIPTION (Continued) C RECEIVED LABELED RIGHT NONSENTINEL NODE #1 IS A 3.4 X 2 X 1.5 CM PORTION OF YELLOW FATTY TISSUE WHICH IS A GROSSLY FAT REPLACED LYMPH NODE SUBMITTED ENTIRELY LABELED CI THROUGH C3. D RECEIVED LABELED RIGHT BREAST SIMPLE MASTECTOMY STITCH AT 12 O'CLOCK IS A 1,250 GRAM SIMPLE MASTECTOMY WHICH INCLUDES IRREGULAR ADDITIONAL FRAGMENTS OF YELLOW-RED FATTY TISSUE IN AGGREGATE MEASURING 9 X 7 X 1 CM. THIS TISSUE IS NOT ORIENTED. THE MASTECTOMY ITSELF MEASURES 28.5 X 21 X 5 CM.  THE NIPPLE IS FLATTENED AND SITS WITHIN A 26 X 13 CM SKIN ELLIPSE. THERE IS PALPABLE FIRMNESS IN THE LOWER OUTER QUADRANT.  THE SUPERFICIAL ASPECT OF THE MASTECTOMY IS MARKED WITH BLUE INK, THE DEEP WITH BLACK. SECTIONING REVEALS 2 DISTINCT FIRM MASSES, ONE IN THE 12 O'CLOCK AREA AND THE 2ND CORRESPONDING TO THE PALPABLE FIRMNESS IN THE LOWER OUTER QUADRANT. THIS HAS A RIBBON CLIP AND THE 12 O'CLOCK LESION HAS A WING CLIP. THE DEEP MARGIN ASSOCIATED WITH THE LOWER OUTER QUADRANT LESION IS FIRM AND PINK-TAN FIBROUS TISSUE DOES EXTEND TOWARDS THE MARGIN BUT THE ACTUAL FIRM MASS IS GROSSLY WITHIN THE CONFINES. THE LOWER OUTER MASS MEASURES 2.5 X 2.5 X 2.5 CM. THE 12 O'CLOCK MASS IS SEPARATED BY CM) OF TISSUE AND MEASURES 3.5 X 2.5 X 2.5 CM IN GREATEST DIMENSION. ADDITIONAL PINK-TAN FIBROUS TISSUE IS FOUND IN THE MIDPORTION OF THE SPECIMEN WHICH IS THEN SURROUNDED BY YELLOW FATTY TISSUE. SECTIONS ARE SUBMITTED AS FOLLOWS: D1--NIPPLE, D2 AND 3--DEEP MARGIN OVER LOWER OUTER QUADRANT LESION, D4--DEEP MARGIN TO 12 O'CLOCK LESION, D5 AND 6--12 O'CLOCK LESION, D7 THROUGH D9--LONGITUDINAL SECTION OF 12 O'CLOCK LESION, D10--TISSUE BETWEEN THE 2 LESIONS, D11 AND 12--LOWER OUTER QUADRANT LESION LONGITUDINAL SECTION, D13--TUMOR LOWER OUTER QUADRANT. THE TISSUE TO THE 6 O'CLOCK MARGIN OF THE LOWER OUTER QUADRANT LESION IS NODULAR AND FOCALLY THERE IS BROWN DISCOLORATION. A SECTION IS SUBMITTED IN D14. THIS IS 1 CM FROM THE LOWER OUTER QUADRANT LESION AND 5 CM FROM THE 12 O'CLOCK LESION. OTHER NODULES DEMONSTRATE CYSTS AS A SECTION IN D1S DEMONSTRATES.  D16--UPPER INNER QUADRANT (3 CM FROM 12 O' CLOCK LESION), D17--UPPER OUTER QUADRANT (5 CM FROM 12 O'CLOCK LESION), D18--LOWER OUTER QUADRANT (3 CM FROM LOWER OUTER QUADRANT) LESION).  THE SEPARATELY SUBMITTED PORTIONS OF FATTY TISSUE ARE GROSSLY UNREMARKABLE AND REPRESENTATIVE TISSUE IS SUBMITTED IN D2O AND 21. RECEIVED LABELED RIGHT AXILLARY NODE CONTENTS IS YELLOW-RED FATTY TISSUE MEASURING 12 X 9.5 X 2.5 CM. THE TISSUE IS EXAMINED FOR LYMPH NODES. LYMPH NODES ARE IDENTIFIED AND SUBMITTED AS FOLLOWS: E1--ONE-HALF OF A FIRM NODE WITH MIRROR IMAGE SUBMITTED PER PROTOCOL,  E2--1 NODE BISECTED, E3--1 NODE BISECTED (MAY ACTUALLY REPRESENT 2 IMMEDIATELY ADJACENT NODES), E4--1 NODE TRISECTED, ES--1 NODE BISECTED, E6--1 NODE BISECTED, E7--1 NODE TRISECTED, E8--3 NODES (1 BISECTED), E9--6 NODES, E1O--1 NODE BISECTED. 1cs-0 -3 Ku 12/i311 UNos Cso.? Site: brst
+
+--- Page 2 ---
+SOUT Req#: Received: Status: Specimen: Spec Type: SURGICAL P Subm Dr: PREOPERATIVE DIAGNOSIS RIGHT BREAST CANCER INVASIVE OPERATION PERFORMEDS DATE: DOCTOR(S) : SENTINEL NODE BX/LYMPHADENECTOMY/STMPLE MASTE TOMY/AXILLAR PROCEDURE: PROCEDURE(CONT): NODE DISGECTION TISSUE REMOVED A. RT SENTINEL NODE #1 - FS B. RT 1 SENTINEL NODE #2 - FS c. RT AXILLARY NON SENTINEL NODE D. RT BREAST SIMPLE MASTECTOMY E. RT AXILLARY NODE CONTENTS FROZEN SECTION DIACNOSIS A. NEGATIVE FOR TUMORS B. METASTATIC CARCINOMA GROSS_DESCRIPTION THE SPECIMEN IS RECEIVED IN 5 PARTS. RIGHT AXILLARY SENTINEL PART A IS RECEIVED DESIGNATED NODE 1 GAMMA HOT AT IT IS RECEIVED IN THE FRESH STATE FOR FROZEN SECTION AND CONSISTS OF A 3.5 X 2.3 X 0.5 CM FRAGMENT OF YELLOWISH-PINK FIBROADIPOSE TISSUE WITH 2 PALPABLE NODULES MEASURING 2 X  EACH NODULE IS PINKISH-RED AND 1.2 X 0.6 CM AND 0.8 X 0.8 X 0.5 CM. ONE-HALF OF EACH IS SECTIONING SHOWS REDDISH-PINK CROSS SECTION. SUBSEQUENT TO THE FROZEN SUBMITTED FOR FROZEN SECTION LABELED FSA. THE SECTION, THE FROZEN TISSUE IS SUBMITTED FOR PERMANENTS LABELED FSA.S REMAINING UNFROZEN NODULES ARE SUBMITTED FOR PERMANENTS LABELED A. RIGHT AXILLARY SENTINEL PART B IS RECEIVED DESIGNATED NODE 2 GAMMA HOT/BLUE AT IT IS RECEIVED IN THE FRESH STATE FOR FROZEN SECTION AND CONSISTS OF A 2.7 X 2.1 X 0.5 CM FRAGMENT OF YELLOWISH-PINK FIBROADIPOSE TISSUE WITH PALPABLE NODULE. THE NODULE IS THE NODULE IS ISOLATED AND FOUND TO MEASURE 1.7 X 1.4 X 0.5 CM. BISECTED SHOWING A REDDISH-PINK RIM SURROUNDING YELLOW ADIPOSE TISSUE WITH A GLISTENING WHITISH-TAN NODULE AT ONE MARGIN MEASURING O.4 CM IN DIAMETER.  SUBSEQUENT TO THE FROZEN SECTION, THE FROZEN TISSUE IS THE REMAINDER OF THE NODULE IS SUBMITTED FOR PERMANENTS LABELED FSB. SUBMITTED FOR PERMANENTS LABELED B.
+
+--- Page 3 ---
+at Snued Received: Status: Req#: Specimen: Spec Type: : SURGICAL P Subm Dr: (Continued) PATH PROCEDURES PROCEDURES: 88305, 88307/2, 88309, PATH FS /2, A BLK, B BLK, C BLK, D BLK/21, E BLK/10, FS-A, FROZ.SEC.-B FINAL DIAGNOSIS PART A RIGHT AXILLARY SENTINEL LYMPH NODE #1, BIOPSY: NO EVIDENCE OF MALIGNANCY . PART B RIGHT AXILLARY SENTINEL LYMPH NODE #2, BIOPSY: METASTATIC BREAST CARCINOMA HAVING A MAXIMUM MICROSCOPIC DIMENSION OF O.6 CM IS IDENTIFIED IN 1 LYMPH NODE EXAMINED. THERE IS NO EVIDENCE OF EXTRANODAL EXTENSION OF TUMOR. PART C RIGHT AXILLARY NONSENTINEL LYMPH NODE, BIOPSY: NO EVIDENCE OF MALIGNANCY IN 1 LYMPH NODE EXAMINED. PART D RIGHT BREAST, SIMPLE MASTECTOMY: 1Lc 3|y 1. MULTICENTRIC)INTRALOBULAR, AND INFILTRATING LOBULAR CARCINOMA OF THE PLEOMORPHIC TYPE. THE INVASIVE COMPONENT SHOWS NUCLEAR GRADE 2/3,S LOW MITOTIC INDEX, AND TUBULE FORMATION 3 WITH TOTAL NOTTINGHAM SCORE OF 6. MITOTIC INDEX COMPRISES APPROXIMATELY SO% OF THE TUMOR. pleo 2. THE LARGEST FOCUS OF INVASIVE TUMOR MEASURES 3.5 CM IN GREATEST DIMENSION AND IS LOCATED  IN THE 12 O'CLOCK PORTION OF THE BREAST. 3.5cm 12. THE SECOND LARGEST MEASURES 2.5 CM AND IS SEEN IN THE LOWER OUTER ADDITIONAL SMALLER FOCI OF INVASION MEASURING FROM I MM TO  QUADRANT. .Sem L0q 5 MM IN GREATEST DIMENSION ARE PRESENT. LCIS IS SEEN ON 14 OF 21 BLOCKS EXAMINED HAVING A MAXIMUM CALCULATED DIMENSION OF S.6 CM. 3. THE MARGINS OF RESECTION AND NIPPLE SKIN ARE FREE OF TUMOR. LYMPHOVASCULAR INVASION IS NOT IDENTIFIED.S -LV! 4. PROLIFERATVE FIBROCYSTIC CHANGES INCLUDING INTRADUCTAL PAPILLOMAS, Fcc c|F 5. INTRADUCTAL PAPILLOMATOSIS, MICROSCOPIC COMPLEX SCLEROSING LESIONS, ADENOSIS, APOCRINE METAPLASIA, MICROCYST FORMATION, PATCHY DENSE STROMA AND RARE LUMINAL CALCIFICATIONS. A M Ca#
+
+--- Page 4 ---
+(Continued Received: Status: Req#: Specimen: Spec Type: SURGICAL-P Subm Dr: FINAL DIAGNOSIS (Continued) THE BIOPSY SITES ( ARE PRESENT. 6. RIGHT AXILLA, LYMPH NODE DISSECTION: METASTATIC BREAST PART E CARCINOMA IS IDENTIFIED IN 1 OF 16 LYMPH NODES EXAMINED. NO EVIDENCE OF EXTRANODAL EXTENSION BY TUMOR. 1 Signed (prelim.) Electronically signed by:
\ No newline at end of file
diff --git a/output/text/b013fbbf-8fc3-417e-bb74-90f87446f2b6.txt b/output/text/b013fbbf-8fc3-417e-bb74-90f87446f2b6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..168916caa26d063efa511d6568df801a902850c7
--- /dev/null
+++ b/output/text/b013fbbf-8fc3-417e-bb74-90f87446f2b6.txt
@@ -0,0 +1,21 @@
+
+--- Page 1 ---
+Encounter Date: UUID:60B86A97-E046-4089-B86E-6498CC6F8648 -01A-PR SURGICAL PATHOLOGY (Ord e) Patient Name Cay DOB Results icD-o3 car1nomg,urothial,NOs Specimen #: 81a0|3 Submitting Physician:. si+: b|adder, p0skri0r wal1 Z-29-12 RP C7.4 FINAL DIAGNOSIS A. DESIGNATED LEFT DISTAL URETER, EXCISION: SEGMENT OF URETER, NEGATIVE FOR MALIGNANCY. B. DESIGNATED RIGHT DISTAL URETER, EXCISION: SEGMENT OF URETER, NEGATIVE FOR MALIGNANCY. C. LEFT EXTERNAL ILIAC LYMPH NODES, FIVE, EXCISION: FIVE LYMPH NODES, NEGATIVE FOR TUMOR (O/5). D. LEFT OBTURATOR AND DEEP OBTURATOR LYMPH NODES #2, TWO, EXCISION: TWO LYMPH#SDESNEGATIVE FOR TUMOR (O/2). E. LEFT COMMON ILIAC. LYMPH NODE, ONE, EXCISION: ONE LYMPH NODE, NEGATIVE FOR TUMOR (O/1). F. LEFT PARA-AORTIC.LYMPH NODES, THREE, EXCISION: THREE LYMPH NODES, NEGATIVE FOR TUMOR (O/3). G. PRESACRAL LYMPH NODES, SEVEN, EXCISION:S SEVEN LYMPH NODES, NEGATIVE FOR TUMOR (O/7). H. RIGHT EXTERNAL ILIAC SYWPH- NODES,~FIVE, EXCISION: TWO OF FIVE LYMPH NODES POSITIVE FOR METASTATIC CARCINOMA (2/5). COMMENT: The morphologic features are consistent with urothelial primary. TWO LYMPH NODES, NEGATIVE FOR TUMOR (O/2). J. RIGHT COMMON ILIAC LYMPH NODES, THREE, EXCISION: ONE OF THREE LYMPH NODE POSITIVE FOR METASTATIC CARCINOMA (1/3).
+
+--- Page 2 ---
+Encounter Date: comment: The morphologic features are consistent with urothelial primary. K. RIGHT PARACAVAL LYMPH NODES, FOUR, EXCISION: FOUR LYMPH NODES, NEGATIVE FOR TUMOR (O/4). L. APPENDIX, APPENDECTOMY: FIBROUS AND FIBROADIPOSE OBLITERATION OF APPENDICEAL LUMEN, NEGATIVE FOR TUMOR. M. DESIGNATED LEFT DISTAL URETER, EXCISION. SEGMENT OF URETER, NEGATIVE FOR TUMOR. N. DESIGNATED RIGHT DISTAL URETER, EXCISION: SEGMENT OF URETER, NEGATIVE FOR TUMOR. 0. LEFT OBTURATOR AND DEEP OBTURATOR LYMPH NODES # 1, TEN, EXCISION:S TEN LYMPH NODES, NEGATIVE FOR TUMOR (O/IO). P. RIGHT OBTURATOR AND DEEP OBTURATOR LYMPH NODES #1, FIVE, EXCISION: FIVE LYMPH NODES, NEGATIVE FOR TUMOR (O/5). Q. BLADDER AND PROSTATE, ROBOTIC LAPAROSCOPIC CYSTOPROSTATECTOMY:S URINARY BLADDER: HIGH GRADE INVASIVE UROTHELIAL CARCINOMA. UROTHELIAL CARCINOMA EXTENDS TO THE POSTERIOR INKED SURGICAL MARGIN. BILATERAL URETERAL AND URETHRAL SHAVE MARGINS ARE FREE OF TUMOR. ANGIOLYMPHATIC INVASION IDENTIFIED. PROSTATE GLAND: MULTIFOCAL WELL DIFFERENTIATED PROSTATIC ADENOCARCINOMA, GLEASON GRADE 6 (3 + 3). PROSTATIC GLANDULAR ATROPHY AND NODULAR HYPERPLASIA. SURGICAL MARGINS ARE FREE OF PROSTATIC ADENOCARCINOMA. cOmment: Invasive high grade urothelial carcinoma, 5.0 cm in maximum dimension, involves predominantly the posterior aspect of the bladder wall with extension to the right and left lateral walls. Prostatic adenocarcinoma greatest dimension, 4 mm and is multifocal involving bilateral prostate lobes. Note: Ten specimen blocks requiring reprocessing prior to final microscopic examination. COMMENT Page 2 of 7
+
+--- Page 3 ---
+Encounter Date: URINARY BLADDER SYNOPTIC REPORT SPECIMEN: Bladder. Other (specify): Prostate. PROCEDURE:  Radical cystoprostatectomy. TUMOR SIZE: Greatest dimension: 5 cm. HISTOLOGIC TYPE: - Urothelial (transitional cell) carcinoma. ASSOCIATED EPITHELIAL LESION: - None identified. HISTOLOGIC GRADE: Urothelial carcinoma (WHO - High grade. MICROSCOPIC TUMOR EXTENSION: Perivesical fat. MARGINS: - Margins involved by invasive carcinoma. - Specify margin: Posterior inked surgical margin.. LYMPH VASCULAR INVASION: - Present. PATHOLOGIC STAGING, (pTNM): Primary tumor (pT) - pT3a: Tumor invades perivesical tissue (microscopically). Regional lymph nodes (pN): -pN3 Number of lymph nodes examined: Specify: 47, forty-seven Specify number of lymph nodes involved (any size):. Specify: 3, three Distant metastasis (pM): - Not applicable. RADICAL PROSTATECTOMY SYNOPTIC REPORT PROCEDURE: Other (specify): Radical cystoprostatectomy. PROSTATE SIZE: - Weight: Cannot be assessed. Size: 10.5 x 4.3 cm. LYMPH NODE SAMPLING: - Pelvic lymph node dissection. HISTOLOGIC TYPE: - Adenocarcinoma  (acinar, not otherwise specified). HISTOLOGIC GRADE: Gleason pattern: Primary pattern: - Grade 3 Secondary pattern:  Grade 3 - Tertiary pattern: -- Not applicable - Total Gleason Score: 6 TUMOR QUANTITATION: - Portion (percentage of prostate involved by tumor): 2% and/or tumor size (dominant nodule, if present): :. - Greatest dimension: 4 mm EXTRAPROSTATIC EXTENSION: 1 - Not identified. Page 3 of 7
+
+--- Page 4 ---
+Encounter Date:  SEMINAL VESICLE INVASION: Not identified. MARGINS: - Margins uninvolved by invasive carcinoma.. TREATMENT EFFECT ON CARCINOMA:S - Not identified. LYMPH-VASCULAR INVASION: Not identified. PATHOLOGIC STAGING, (pTNM) : Primary tumor (pT). - pT2c: bilateral disease. Regional lymph nodes (pN). - pN0: no regional metastasis. - Number of lymph nodes examined: 47, forty-seven. - Number involved: O, zero [See comment]. Distant metastasis (pM): - Not applicable. cOmmEnT: Metastatic carcinoma in three lymph nodes sited in the Urinary Bladder template above is consistent with urothelial origin, not prostatic origin. Final sign out performed at (Electronic Signature) SPECIMEN SUBMITTED A: LEFT DISTAL URETER B: RIGHT DISTAL URETER C: LEFT EXTERNAL ILIAC D: LEFT  OBTURATOR AND DEEP OBTURATOR #2S E: LEFT  COMMON ILIAC F: LEFT PARA-AORTIC G: PRE-SACRAL H: RIGHT EXTERNAL ILIAC I: RIGHT OBTURATOR AND DEEP OBTURATOR #2 J: RIGHT COMMON ILIAC K: RIGHT PARACAVAL L: APPENDIX M: DISTAL LEFT URETER (CLIP ON MOST DISTAL) N: DISTAL RIGHT URETER (CLIP ON MOST DISTAL) O: LEFT OBTURATOR AND DEEP OBTURATOR #1 P: RIGHT OBTURATOR AND DEEP OBTURATOR #1 Q: BLADDER AND PROSTATE CLINICAL DATA Ca bladder INTRAOPERATIVE CONSULT DIAGNOSISS A. F.s.: Segment of ureter, negative for malignancy. B. F.s.: Segment of ureter, negative for malignancy. Q. F.s.: Urethral line of resection, negative for malignancy.. Page 4 of 7
+
+--- Page 5 ---
+Encounter Date:  GROSS DESCRIPTION A. Received fresh for frozen section consultation is a specimen labeled distal ureter. The specimen consists of a tubular segment of tan soft tissue measuring 1.0 cm. in length and 0.5 cm. in width. A pinpoint lumen is present. The specimen is totally submitted as follows: Al - frozen section. A2 - remainder of specimen.. B. Received fresh for frozen section consultation labeled right distal ureter is a tubular segment of tan-pink soft tissue measuring 0.7 cm. in length and 0.6 cm. in width. Soft yellow adipose tissue is attached to one surface. The specimen is totally submitted as follows:. B1 - frozen section. B2 - remaining soft tissue. C. Received in fixative is an irregular lobulated, yellow-tan rubbery tissue segment 4.5 x 2 x 1.3 cm. On palpation a large nodule consistent with a lymph node is identified which measures 4.5 cm. in greatest dimension. The lymph node has fatty cut surfaces. Two full thickness sections of this node are sectioned and submitted separately in blocks 1 and 2. Two additional small nodules resembling lymph nodes are also identified. These lymph nodes are submitted in block 3. The remaining soft tissue is entirely submitted in blocks 4 and 5. D. Received in fixative is a multiple floating segment of lobulated yellow-tan tissue which aggregates to approximately 2 x 2 cm. On section and on palpation three small areas of nodularity consistent with lymph nodes 0.2 to 0.5 cm. are identified. These lymph nodes are submitted in block 1. The remaining soft tissue is entirely submitted in block 2. E. Received in fixative are floating segments of lobulated, yellow-tan tissue which aggregate to approximately 1.5 x 2 cm. On section definite lymph nodes are not identified. The specimen is entirely submitted in a single cassette as received.. F. Received in fixative are irregular segments of lobulated yellow-tan tissue measuring 3.5 x 2 cm. On section and on palpation three areas of nodularity resembling lymph nodes 1.0 to 1.5 cm. in greatest dimension are identified. These lymph nodes are entirely submitted in block 1. The remaining soft tissue is submitted in block 2.. G. Received in fixative are multiple irregular lobulated yellow-tan tissue segments aggregating to 5 x 3 cm. On section and on palpation small areas of nodularity resembling lymph nodes are identified measuring up to 1 cm. in greatest dimension. Sections of lymph nodes are removed and submitted in block 1. The remaining soft tissue is submitted in blocks 2-5. H. Received in fixative are floating segments of lobulated yellow-tan tissue aggregating to approximately 4 x 2.5 cm. On section and on palpation areas of nodularity resembling lymph nodes are identified. The largest of which measures 2.4 cm. On section and on palpation areas of nodularity consistent with lymph nodes measuring up to 2.5 cm. in greatest dimension is identified. These lymph nodes are removed and submitted in blocks 1 and 2. The remaining soft tissue is submitted in blocks 3 and 4. I. Received in fixative are multiple floating segments of lobulated, yellow-tan tissue which aggregate to approximately 2 x 2 cm. On section and on palpation definite nodules resembling lymph nodes are not identified Page 5 of 7
+
+--- Page 6 ---
+Encounter Date: with certainty. The specimen is entirely submitted in a single cassette as received. J. Received in fixative on a segment of telfa is an irregular segment of lobulated yellow-tan tissue measuring 3 x 2 cm. On section and on palpation an area of nodularity resembling lymph node is identified measuring 2.3 cm. in greatest dimension. It has a centrally fatty focally pink-tan cut surface. The lymph node is bisected and submitted in blocks 1 and 2. The remaining soft tissue is submitted in block 3. K. Received in fixative are floating segments of lobulated, yellow-tan tissue aggregating to 2 x 3 cm. On section and on palpation definite areas of nodularity resembling lymph nodes are identified with certainty. The specimen is entirely submitted in a single cassette. L. Received in fixative is an appendix measuring 4 cm. in length and 0.6 cm. in diameter. Attached periappendiceal adipose tissue measures 3 x 2 cm. A stapled suture line at the proximal margin of the appendix. The serosal surface on transection a pinpoint lumen is identified. No mass lesions are present. The appendix is sectioned and entirely submitted in a single cassette with a section adjacent to the stapled suture line painted with yellow ink. M. Received in fixative is a tubular portion of grey tissue approximately 2 cm. in length and 0.7 cm. in diameter. A suture is present marking the distal margin of the specimen. A section adjacent to the clip representing the margin is submitted in a single cassette. N. Received in fixative is a tubular portion of tan tissue approximately 0.8 cm. in length and 0.7 cm. in diameter. A clip is present on the distal margin of the specimen. A section adjacent to the clip representing the margin is submitted in a single cassette. O. Received in fixative are multiple lobulated yellow-tan tissue segments aggregating to 4.5 x 3 cm. On section and on palpation areas of nodularity consistent with lymph nodes are identified measuring up to 3 cm. in greatest dimension. Sections of lymph nodes are submitted in blocks 1-3 with block 3 containing the largest lymph node which is bisected. The remaining soft tissue is entirely submitted in blocks 4-6. P. Received in fixative is a lobulated, yellow-tan tissue aggregating to 4 x 2 cm. On section and on palpation areas of nodularity consistent with lymph nodes are identified. The lymph nodes are submitted in block 1. The remaining soft tissue is entirely submitted in blocks 2 and 3. Q. Received in fixative is an en bloc resection consisting of prostate with attached seminal vesicles, peribladder and perivesicular adipose tissue. The entire specimen measures 14 x 12.5 x upwards of 7 cm. The prostate measures 10.5 x 4.3 cm. The right half of the prostate gland is painted yellow. The left of the prostate gland is painted black.. The perineal surface posteriorly shows slight nodularity and granularity. The underlying bladder is somewhat firm. The resection surfaces of the perineal surface and the posterior aspect of the bladder is painted with blue ink. The prostatic urethral margin shows two plastic clips present. A section adjacent to the plastic clip representing the margin previously utilized for frozen section is submitted in block l. After the clips are removed the shaved section adjacent to that utilized for frozen section is submitted for permanents in block 2. Each ureter is identified. The resection line of the ureter for this specimen and vas deferens on the right side is submitted in block 3. The resection line of the left ureter Page 6 of 7
+
+--- Page 7 ---
+Encounter Date: for this specimen and vas deferens line of resection submitted in block 4. It is opened in surgery and demonstrates a large lesion present on the posterior wall measuring 5 x 3.9 cm. The lesion has a raised granular focally ulcerated appearance. It abuts the top of the trigone and is present close to the left ureteral orifice and within approximately 0.5 cm. of the right ureteral orifice. A section of the right ureteral orifice is submitted in block 5. A section through the left ureteral orifice is submitted in block 6. Sectioning through the middle of the trigone including the prostatic urethra is submitted in block 7. The tumor upon transection extends through the wall of the bladder and possibly to the blue inked surface. The bladder tumor measures upwards of 1.5 cm.. in thickness. At the time of surgery in the fresh state is a portion of the tumor is taken for tissue procurement for banking. Representative sections of the tumor and posterior wall are submitted in full thickness in blocks 8-1l. The remaining bladder mucosa away from the tumor is somewhat edematous and pink-tan and wrinkled. A representative section from the dome of the bladder is submitted in block 12. A representative section of the left lateral wall of the bladder including the edge of the tumor is submitted in block 13. A representative section of the right lateral wall of the bladder including the edge of the tumor is submitted in block 14. A section through the attached perivesicular adipose tissue demonstrates no grossly enlarged lymph nodes. Sectioning through the prostate demonstrates. predominantly rubbery, pink-tan cut surfaces. No discrete areas of nodularity are identified within the gland. Representative sections from the right half of the prostate gland are submitted in blocks 15-17. Representative sections from the left half of the prostate gland are submitted in blocks 18-20. Upon transection of the seminal vesicles they are grossly unremarkable. A representative section from the right seminal vesicle is submitted in block 2l. A representative section from the left seminal vesicle is submitted in block 22. Multiple representative sections. Patient ID #: Pt. Acct/Enc #: DOB: (Age: Date of Report: Date of Procedure:. Date of Receipt: Submitted bv: Location: Test performed by:. Lab and Collection SURGICAL PATHOLOGY (Order ) on - Lab and Collection Information. Result History SURGICAL PATHOLOGY (Ordee Jor  Order Result History Report.. Result Information Result Date and Time Status Provider Status Final result Reviewed MyChart Status: This result is currently not released to . Display Full Result Report Display Order Report Page 7 of 7
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diff --git a/output/text/b0391d1c-5252-4e91-97b7-4f36209d5375.txt b/output/text/b0391d1c-5252-4e91-97b7-4f36209d5375.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0e2f6d663a313a4c7d01a573cf12547c8422dc7f
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:C0C49D41-AA66-435B-9312-FAD8E2DC3305 TCGA-A7-A4SE-01A-PR Redacted Final Surgical Pathology Report Procedure: Diagnosis A. Breast, left, segmental mastectomy: Invasive ductal carcinoma, grade 3, size 2.8 cm in greatest dimension; negative margins of excision. B. Sentinel lymph node #1, biopsy: Two negative lymph nodes (0/2). C. Sentinel lymph node #2, biopsy:  One negative lymph node (0/l). D. Breast, medial to left segmental mastectomy, biopsy:  Negative for malignancy or atypia. E. Breast, inferior to left segmental mastectomy, biopsy:.  Negative for malignancy or atypia. F. Breast, posterior to left segmental mastectomy, biopsy:. Skeletal muscle; negative for malignancy or atypia.. G. Breast, lateral to left segmental mastectomy, biopsy: Negative for malignancy or atypia. H. Breast, superior to left segmental mastectomy, biopsy: Negative for malignancy or atypia. Microscopic Description: Invasive Carcinoma: Histologic type: Ductal 1cs-0-3 Histologic grade: 3 Overall grade: 9/9 Architectural score: 3 Cacinenu, rifittruHng duct, NOS Nuclear score: 3 8500/3 Mitotic score: 3 Greatest dimension (pT): 2.8 cm Situ: 5rust N0s e5O.9 Specimen margins: Negative Vessel invasion: Not identified Calcification: Present 10/37/12 Ductal carcinoma in situ: Histologic pattern: Solid Nuclear grade: Central Necrosis: Present % Dcis of total tumor (if mixed):. 1% Extensive intraductal component (present/absent): Absent Specimen margins: Negative Calcification:  Negative Description of. non-tumorous breast: Fibrocystic changes, with ductal hyperplasia of usual type, a minute fibroadenoma, and apocrine metaplasia, with calcification. Comments: Sentinel lymph nodes negative, confirmed by negative. cytokeratin immunostaining of blocks BFsl and ces2. Cytokeratin staining was also performed on one block from part E, to exclude involvement by carcinoma. Prior biopsy site identified. Extensive central tumor necrosis is present. Prognostic markers: See core biopsy report, 4x8, 14x2, 15x2, 20x3 {A few of the antibodies used in our laboratory may be classified as analyte specific reagents. These antibodies are monitored and controlled in our laboratory and their performance for in vitro diagnosis is well described in the medical literature.  They have not been cleared or approved by the FDA.]
+
+--- Page 2 ---
+Specimen A. Left Breast B. Left axillary sentinel lymph node #1, hot, blue, C. Left axillary sentinel lymph node #2, not hot, not blue, but palpable D. Medial to segmental mastectomy left breast E. Inferior to segmental mastectomy left breast F. Posterior to segmental mastectomy left breast G. Lateral to segmental mastectomy left breast H. Superior to segmental mastectomy left breast Clinical Information Left breast cancer Intraoperative Consultation B) Left axillary sentinel node #l: Two negative lymph nodes (0/2). c) Left axillary sentinel node #2, biopsy: One negative lymph node (0/1). Gross Description A. Received unfixed for tissue procurement, labeled left breast segmental mastectomy single long lateral, double long anterior, is a i00 gram breast segmental excision that is 9 cm from anterior to posterior, 7.5 cm medial to lateral,  and 3 cm from superior to inferior. The superior surface is inked black, and a section is. submitted for tissue procurement as requested. An additional section of uninvolved fatty tissue is submitted from the posterior aspect, for procurement. Additional sections after fixation. The superior surface is inked black, medial green, lateral yellow, inferior blue.  There is a tan, firm, lobulated mass lesion in the mid-portion of the specimen, 3.0 x 2.0 x 1.7 cm..  This is 3 mm from the green-inked medial margin (closest margin). All other margins are grossly greater than 1 cm from the mass. Representative sections: '1 Anterior margin, 2 adjacent section with margin, 3/4/5 contiguous tumor, possible biopsy cavity in 5, 6/7/8 contiguous, 9-10 random medial and lateral, possible close margin, 11-i4 additional posterior sections, with last section = posterior margin. B. Received unfixed for frozen section, labeled left axillary sentinel node #1, are 2 adjacent and attached lymph nodes, 0.9 cm in greatest dimension each, bisected and entirely submitted in blocks B1 and B2. C. Received unfixed for frozen section, labeled left axillary sentinel node.#2, is a single lymph node, 1.4 x 1.3.x 1.0 cm, bisected and entirely submitted in 2 blocks. D. Received fresh and subsequently fixed in formalin labeled "medial to segmental mastectomy left breast "is a 5.2 x 3.5 x 1.5 cm yellow lobular fatty tissue fragment which has a suture designating the new medial border. The surface is inked and the specimen is sectioned to show yellow lobular fatty cut surface with minimal fibrous tissue present. No discrete residual tumor is grossly identified. The specimen is entirely submitted labeled 1 through 10. E. Received fresh and subsequently fixed in formalin labeled "inferior to segmental mastectomy left breast "is a 4.3 x 2.7 x 2.2 cm yellow lobular fatty tissue fragment which has a suture designating new inferior border. The surface is inked and the specimen is sectioned to show yellow lobular fatty cut surface with minimal fibrous tissue present. No residual tumor is grossly identified. The specimen is entirely submitted labeled i through 9.
+
+--- Page 3 ---
+F. Received fresh and subsequently fixed in formalin labeled. 1.0 cm yellow lobular fatty tissue fragment which is partially covered with skeletal muscle. There is a suture designating the new posterior margin. The surface is inked and the specimen is sectioned to show a yellow lobular fatty cut surface with scanty fibrous tissue present. The specimen is entirely submitted in 5 cassettes. G. Received fresh and subsequently fixed in formalin labeled "lateral to segmental mastectomy left breast "is a 4.3 x 3.5 x 1.5 cm yellow. lobular fatty tissue fragment. There is a suture designating the new lateral border. The surface is inked and the specimen is sectioned to show yellow lobular fatty cut surface with minimal. fibrous tissue present. No residual tumor is grossly identified. The specimen is entirely submitted in 9 cassettes.. H. Received fresh and subsequently fixed in formalin labeled "superior segmental mastectomy left breast "is a 4.3 x 2.2 x 1.0 cm yellow lobular fatty tissue fragment which has a suture designating the new superior border. This is inked and the specimen is sectioned to show yellow lobular fatty cut surface with scanty fibrous tissue present. The specimen is entirely submitted in'4 cassettes. Diaendub!
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diff --git a/output/text/b045bc39-1f18-4248-90fc-2bc2ba9a74c3.txt b/output/text/b045bc39-1f18-4248-90fc-2bc2ba9a74c3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..283e378da2a8a69ad1ec5ec887874d842c20927e
--- /dev/null
+++ b/output/text/b045bc39-1f18-4248-90fc-2bc2ba9a74c3.txt
@@ -0,0 +1,24 @@
+
+--- Page 1 ---
+TcD-6-3 arcinomo,in fr/trctivg FINAL PATHOLOGIC DIAGNOSIS ducte1 s&o/3 A. Right axillary sentinel lymph node #1, biopsy: Site: RBreat HoS c309 - Metastatic ductal carcinoma (1.3cm) involving single lymph node (1/1) w Q|18/i3 B. Right axillary sentinel lymph node #2, biopsy:. - One lymph node, no tumor (0/1) UUID:C8297152-7551-49A1-8C9D-6B411391AC77 TCGA-OL-A5RY-01A-PR Redacted C. Right axillary sentinel lymph node #3, biopsy:. - One lymph node, no tumor (0/1) D. Right axillary non sentinel lymph node, biopsy: - One lymph node, no tumor (0/1) E. Right breast, wire-guided lumpectomy: - Invasive ductal carcinoma, SBR Ill, multiple foci (largest 1.3cm) - Ductal carcinoma in situ high grade, solid, cribriform and micropapillary. types with central necrosis and associated calcifications; DCiS spans entire specimen (8cm in greatest dimension) F. Right breast, new inferior lateral margin, excision: - Ductal carcinoma in situ, intermediate grade, microscopic foci (largest 5mm) - Microscopic foci (each 1mm) of DciS present at outer medial aspect of specimen G. Right breast, new outer lateral margin, excision:. - Ductal carcinoma in situ, rare microscopic foci (largest 1mm) - DCiS >1cm from nearest new margin Breast Pathologic Parameters 1. Invasive carcinoma: A. Microscopic measurement: Multifocal; largest focus (measures 1.3cm). B. Composite histologic (modified SBR) grade: III (largest focus)
+
+--- Page 2 ---
+- Architecture: 2 - Nuclear grade: 3 - Mitotic count: 3 c. Associated intraductal carcinoma in situ (DciS): - High grade, solid, cribriform and micropapillary types - Dcis involves entire specimen and spans 8cm in greatest dimension 2. Excisional biopsy margins: Positive - Dcis present at medial margin, <1mm from anterior, posterior, lateral, superior, and inferior margins (tumor approaches margins at multiple foci throughout specimen) - Invasive carcinoma at inferior and 1mm from posterior margin; additional margins greater than 2mm away 3. Blood vessel and lymphatic invasion: Present in breast parenchyma 4. Axillary lymph nodes: Positive (1/4) - Size of largest metastatic deposit: 13 mm - Extranodal extension: absent 5. Special studies. - ER: Weak expression in 10% of invasive tumor nuclei - PR: No expression - Her2/neu antigen (FisH): Amplified (ratio: 7.6) 6. pTNM (AJCC, 7th edition, 2010): pT1c(m), N1(sn), MX Effective is Checklist utilizes the 7th edition TNM staging system for breast of the American Joint Committee on Cancer (AJcC) and the International Union Against Cancer (UIcC)
+
+--- Page 3 ---
+has1 Interpretation performed by the Attending Pathologist and reviewed with the Resident/Fellow Electronically Signed Out by Clinical History: Patient is a. -year-old female with right breast IDC undergoing lumpectomy and  sentinel lymph node biopsy. Specimens Received: A: Sentinel lymph node #1 B: Sentinel lymph node #2 C: Sentinel lymph node #3 D: Non-sentinel lymph node E: Right wire-guided lumpectomy F: Right breast new inferior lateral margin. G: New outer lateral margin
+
+--- Page 4 ---
+Gross Description: The specimens are received in seven containers each labeled with the patient's name and medical record number.. A. The first container is additionally identified as, 'sentinel lymph node #1'. Received fresh and placed in formalin the specimen consists of a 1.5 x 1 x 1 cm lymph node which is serially sectioned and entirely submitted in cassette A1. B. The second container is additionally identified as, 'sentinel lymph node #2'. Received fresh and placed in formalin the specimen consists of a 1 x 0.5 x 0.3 cm lymph node which is bisected and is entirely submitted in cassettes B1. C. The third container is additionallyidentified as, 'sentinel lymph node #3'. Received fresh and placed in formalin the specimen consists of a 0.7 x 0.3 x 0.3 cm lymph node which is entirely submitted in cassette C1.. D. The fourth container is additionally identified as, 'non-sentinel lymph node'. Received fresh and placed in formalin the specimen consists of a 0.5 x 0.3 x 0.3 cm lymph node which is entirely submitted in cassette D1. E. The fifth container is additionally identified as, 'right wire guided lumpectomy'. Received fresh on a radiographic grid is a 102 gm lumpectomy specimen measuring 8 cm from medial to lateral, and 8 in cm from superior to inferior and 3 cm from anterior to posterior. The specimen is oriented with a short suture designating the superior pole and a long suture designating the
+
+--- Page 5 ---
+Iateral pole. There is a wire entering the antero-lateral aspect of the specimen through grid coordinate E5. Accompanying the specimen is an x-ray demonstrating a metallic clip located in grid coordinate E3. There is a circled mass in grid positions C3, C4, D3, D4, centered on the clip. The wire enters the specimen in grid coordinates E5 terminates in E3. 2 other areas of calcifications are circled in grid coordinates D6 (#2) and F4-F5 (#3). The margins are inked as follows: anterior - black; posterior - red; superior - blue; inferior - green; medial - yellow; Iateral - violet. The specimen is serially sectioned from medial to lateral into 8 slices. The area of calcifications noted in grid D6 begins in the slides #2 and extends Iaterally the tumor the main to mass and measures 3 x 2 x 1.5 cm. is found in the slices #2 and 3 adjacent to the red and green ink. The main mass, which is irregular and firm, is present in slices #5 to #7 and measures 3.5 x 2.5 x 2 cm. It is present adjacent to red ink and is 1 cm from black ink, 3 cm from green ink, 1.5 cm away from blue ink. The area of calcification noted in grid F4 and F5 is present in the slices numbers 7 and activated ink measuring 1.5 x 1.1 x 1 cm and is continuous with the main mass. The metallic clip is identified in slice 6. The wire enters the specimen in slice 5 and terminates in slice 5. The remainder of the breast parenchyma is white-yellow and lobulated with no additional masses or lesions
+
+--- Page 6 ---
+Entire mass including both calcified area was has a largest dimension of 5 cm. Specimen is submitted in toto.. Block summary: E1-E4: medial margin, slice 1 E5-E9: slice 2, area of calcification E10-E23: slice 3, area of calcification E24-E31: slice 4 E32-E44 ; slice 5 E45-E62: slice 6, clip in E49-E50 E63-E78: slice 7 E79-E86: lateral margin, slice 8 F. The sixth container is additionally identified as, 'right breast, new inferior lateral margin'. Received fresh on the radiographic grid is a 13.5 gm, 6.5 x 4 x 1.2 cm medial inferior lateral margin which is oriented as follows: - new outer lateral margin is marked with a long black stitch (violet) - new outer medial margin is designated with a short black stitch (yellow). - new outer anterior margin is designated with a short blue stitch (black) - new outer posterior margin is designated with a long blue stitch. (red) Inner cauterized margin is inked green. An area of calcification is noted on the accompanying x-ray in grid D4-D5-E5. Specimen is a serially sectioned from
+
+--- Page 7 ---
+Iateral to medial in to 14 slices. An area of calcification is present in slice #6 and measures 1 x 0.5 x 0.3 cm. No other lesions are identified. The specimen is entirely submitted from lateral to medial. F1: slice 1-3 F2: slice 4-5 F3: slice 6 F4: slice 7 F5-F6: slice 8 F7: slice 9 F8: slice 10 F9: slice 11 F10: slice 12 F11: slice 13-14 G. The seventh container is additionally identified as, 'new outer lateral margin'. Received fresh ona radiographic grid is a 20 gm, 8 x 3.5 x 1 cm new outer lateral margin. Specimen is oriented as follows - new outer superior is designated with a short black stitch (blue). - new outer inferior is designated with a long black a stitch (green). - new outer anterior is designated with a short blue stitch (black) - new outer posterior is designated with a long blue stitch (red). Inner cauterized margin is inked violet. Specimen is serially sectioned from Iateral to medial into 14 slices and does not contain any distinct masses or
+
+--- Page 8 ---
+lesions. Specimen is submitted in toto in cassettes G1-14. 03
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new file mode 100644
index 0000000000000000000000000000000000000000..811a832cca39879c9f7d3882c1ee8ce087bfcc3e
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+
+--- Page 1 ---
+ID-0 3 ytI o/13|14 UUID:13D31CA3-FECE-432E-B292-CF368DFDADE5 TCGA-5P-A9K4-01A-PR Redacted Papillary Renal Cell Carcinoma, Type I, moderately differentiated Stage: pT1b, RO Grade: GII ICD-0-Code: 8260/3 Lasterwlity hw 5/l/Y
\ No newline at end of file
diff --git a/output/text/b0861612-a408-4087-8b5e-c746683754b8.txt b/output/text/b0861612-a408-4087-8b5e-c746683754b8.txt
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index 0000000000000000000000000000000000000000..7e1b3010e8fe6404ceda5d357e7215ee256c37d1
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+
+--- Page 1 ---
+SPECIMEN A.  Right colon and terminal ileum B. Hernia sac, left inguinal C. Omentum CLINICAL NOTES PRE-OP DIAgnosIS: Right colon cancer. CLINIcAL HIsToRy: Large cecal cancer, bilateral inguinal hernia left containing small bowel and sigmoid. Right containing appendix. GROSS DESCRIPTION A. Received fresh for tissue procurement labeled "right colon and terminal ileum" is a previously unopened 25 cm. segment of proximal right colon with attached 20 cm. of distal ileum surfaced by smooth to scabrous tan pink serosa with a copious amount of attached mucin colon, mesentery and unremarkable omentum. An appendix measuring 6.6 cm. in length which ranges from 0.7 cm. proximally up to 1.5 cm. distally is present. A scant amount of tan white fibrinopurulent exudate appears to be present, adjacent to the distal tip. On sectioning, the lumen is pinpoint, surrounded by unremarkable tan pink mucosa and no discrete transmural defect is identified. The proximal and distal margins measure 4.0 and 5.8 cm. in circumference respectively. On opening, there is a nearly circumferential 10.0 x 7.8 cm. firm tan pink to papilliferous tan red lesion present at and distal to the ileocecal valve. On sectioning, the lesion has a maximal thickness of 3.4 cm. with extension into the surrounding mesentery to within 0.5 cm. of the inked free radial serosal surface. The colonic mucosa is otherwise glistening tan pink with regular folds in the wall averaging 4 cm. in thickness. Several additional purple tan pink to tan red polypoid lesions measuring up to 1.2 cm. in greatest dimension are present. The largest polyp is 7 cm. distal from the mass. The ileal mucosa is unremarkable, glistening tan pink with regular folds and the wall averages 0.5 cm. in thickness. A portion of tumor and portion of normal mucosa are submitted for tissue procurement as requested. Multiple rubbery tan white to tan pink tissues in keeping with lymph nodes measuring up to 6 cm. in greatest dimension. The four largest lymph nodes appear involved by metastasis (representative sections only given). Representative sections are submitted in eighteen blocks as labeled. RS-18.
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+BLOcK SumMARy: 1 - Proximal and distal margins; 2-5 - tumor to inked free radial serosal surface (cassette 4 and 5 contain bisected single slice with point of continuity inked orange); 6 - tumor to distal mucosa; 7-9 - additional colonic polyps (7 - one polyp, 7 cm. distal from large tumor, 8 and 9 - two polyps per cassette); 10 - random ileum and colon; 11 - proximal appendix and one-half of. bisected distal tip; 12 - remainder of bisected distal tip; 13 six whole lymph nodes; 14 - five whole lymph nodes; 15 - four whole lymph nodes; 16 - representative of two grossly positive lymph nodes; 17,18 - representative of two g itive lymph nodes. (one node represented per cassette). B. Received fresh, subsequently fixed in formalin labeled "hernia left inguinal" is an 11 x 6.5 x 1.5 cm. pink-tan. fibromembranous saccular tissue with yellow lobular fat. The specimen is sectioned to show no other discrete gross lesions. identified. Representative sections of the specimen are submitted in two cassettes. Rs-2 C. Received fresh, subsequently fixed in formalin labeled "omentum" is a 13 x 8 x 3 cm. piece of fatty tissue consistent with omentum. The specimen is sectioned to show a yellow. lobular fatty cut surface which is grossly consistent with omental fat. No discrete gross lesions are identified or palpated. Representative se. ions of the specimen are submitted in eight. cassettes. Rs-8 MICROSCOPIC DESCRIPTION A. Microscopic examination of the right colon and terminal ileum resection specimen reveals Histologic type: Invasive adenocarcinoma not otherwise specified Histologic grade: Moderately differentiated. Primary tumor (pT): Tumor originates in cecum and extensively infiltrates through the wall of the cecum and is present on the serosal surface/penetrates visceral peritoneum (pT4A). Proximal margin: Negative for tumor Distal margin: Negative for tumor Circumferential (radial) margin: Not applicable.. Distance of tumor from closest margin: 20 cm. from proximal margin Vascular invasion: Prominent lymphatic space invasion is present.. Regional lymph nodes (pN): Metastatic adenocarcinoma is present in. 4 of 17 lymph nodes (pN2a)
+
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+Non-lymph node pericolonic tumor: Present with prominent extranodal tumor metastases adjacent to the appendix in the periappendiceal fat and adjacent to the large pericolonic lymph nodes. Distant metastasis (pM): Cannot evaluate pMx Other findings: Five adenomatous polyps are present. Deep to the largest adenomatous polyp which is 7 cm. distal from the large primary tumor there is intracolonic metastasis with additional adenocarcinoma present in the muscularis propria and in dilated lymphatic spaces. B. Microscopic examination reveals benign fibromembranous tissue lined by mesothelium consistent with hernia sacs. No tumor is identified within the hernia sac tissue. C. Microscopic examination of the omentum reveals fatty tissue. No metastatic tumor is identified in the omentum. DIAGNOSIS A. Right colon and terminal ileum, resection: Invasive moderately differentiated adenocarcinoma of the cecum invasive through the entire colonic wall through the visceral peritoneum present on serosal surface (pT4a). Much lymphatic space invasion present, intracolonic metastasis present 7 cm. distal to tumor. Five additional adenomatous polyps present. Metastatic adenocarcinoma present in 5 of 18 pericolonic lymph nodes (pN2a).  Extranodal tumor present including periappendiceal extranodal metastatic tumor. Mucosal margins negative for tumor. B. Hernia sac, left inguinal, resection: Benign hernia sac tissue, no malignancy identified. C. Omentum, excision: Benign omental fat, no malignancy identified. End Of Report
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diff --git a/output/text/b0a6afdb-2516-4347-bcf0-efb7cc853b5a.txt b/output/text/b0a6afdb-2516-4347-bcf0-efb7cc853b5a.txt
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index 0000000000000000000000000000000000000000..ac892599db31ad86f1ec085b274d37a98e73f7da
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+
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+UUID:75642D9B-7F8C-4E99-A19C-B610D21BFACD TCGA-CQ-7072-01A-PR Redacted Page 1 of 6 Patient Name MRN Visit Number Event Date and Time Procedure Ordered Status Ordered By Specimen # Surgical Pathology Report supplemental : Collection Date: Accession Dat Result Date: Surgical Pathology Consultation Report * Addended * SPECIMEN(S) RECEIVED 1. Nck: RT.neck level 2B 2. Neck: Right neck level II 3. Neck: Right neck level III 4. Neck: Right neck level IV 5. Neck: Right neck level I 5. Soft Tissue: Right partial glossectomy and right partial mandibulectomy - 7. Neck: Left neck level I, II 3. Oral Cavity: Left floor of mouth - ). Soft Tissue: Left sublingual gland - 10. Soft Tissue: Left ventral tongue - 11. Soft Tissue: Deep tongue margin - 12. Soft Tissue: Right tongue margin - 13. Soft Tissue: Deep midline muscle - 14. Surgical Waste. DIAGNOSIS I. Right neck level IIB. Six lymph nodes negative for tumor (0/6). 2. Right neck level II. Four lymph nodes negative for tumor (0/4) 3. Right neck level III. Soft tissues with no pathologic changes. No lymph nodes present. 1. Right neck level IV. Eight lymph nodes negative for tumor (0/8). 5. Right neck level I. Two lymph nodes negative for tumor (0/2) Submandibular gland with moderate atrophy. Negative for tumor.
+
+--- Page 2 ---
+Page 2 of 6 6. Oral cavity; tongue; right partial glossectomy and right partial mandibulectomy. -Squamous cell carcinoma, moderately differentiated. a. Tumor maximum diameter 3.2 cm. b. Tumor thickness 1.2 cm. c. Extensive perineural invasion is present.. d. No lymphatic/vascular invasion. e. The lateral margin is close (0.3 cm) to tumor. The remaining margins are negative for tumor. f. Squamous carcinoma in-situ is also present. g. Sections of the mandible are pending. An addendum report wil follow. 7. Left neck level I and II.. -Eight lymph nodes negative for tumor (0/8). -Submandibular gland with no pathologic changes. Negative for tumor. 8. Left floor of mouth. -Negative for tumor. 9. Left sublingual gland. -Sublingual gland with no pathologic changes.. 10. Left ventral tongue. Negative for tumor. 11. Deep tongue margin. Negative for tumor. 12. Right tongue margin. Negative for tumor. 13. Deep midline muscle.. Negative for tumor. 14. Surgical waste. Bone and soft tissues with no pathologic changes. (Gross examination only) SYNOPTIC DATA Specimen Type: Resection:right partial glossectomy and right partial mandibulectomy. Tumor Site: Tongue Histologic Type: Squamous cell carcinoma, conventional Tumor Size: Greatest dimension: 3.2 cm Tumor thickness: 1.2 cm Histologic Grade: G3: Poorly differentiated Venous/Lymphatic (Large/Small Vessel) Invasion (V/L): Absent Perineural Invasion: Present
+
+--- Page 3 ---
+Page 3 of 6 Additional Pathologic Findings: Carcinoma in situ. Margins: Margins uninvolved by tumor Margins uninvolved by tumor - Distance of tumor from closest margin: 0.3 cm Margins: lateral : Pathologic Staging (pTNM): pT2: Tumor of lip or oral cavity more than 2 cm but not more than 4 cm in greatest dimension. pN0: No regional lymph node metastasis for aerodigestive sites Number of regional lymph nodes examined: 28 Number of regional lymph nodes. involved: 0 MX: Distant metastasis cannot be assessed ELECTRONICALLY VERIFIEL 3ROSS DESCRIPTION I. The specimen is labeled with the patient's name and "Neck: Right neck level I B". It consists of portion of fibroadipose tissue measuring 3.0 x 3.0 x 1.5 :m. Multiple lymph nodes ranging from 0.8 to 1.5 cm are identified. Representative sections are submitted. IA-1B one lymph node each |C four lymph nodes 2. The specimen is labeled with the patient's name and 'Neck: Right neck level .I": It consists of portion of fibroadipose tissue measuring 3.0 x 2.5 x 1.0 :m. Multiple lymph nodes ranging from 0.4 to 1.2 cm are identified. Representative sections are submitted. A one Iymph node B multiple lymph nodes 3. The specimen is labeled with the patient's name and "Neck: Right neck level II". It consists of portion of fibroadipose tissue measuring 3.5 x 3.0 x 2.5 :m. No lymph nodes are identified. 'A representative sections l. The specimen is labeled with the patient's name and "Neck: Right neck level V". It consists of portion of fibroadipose tissue measuring 3.5 x 3.0 x 1.5  m. Multiple Iymph nodes ranging from 0.3 to 1.2 cm are identified. Representative sections are submitted. A-4B multiple lymph nodes each i. The specimen is labeled with the patient's name and "Neck: Right neck level
+
+--- Page 4 ---
+ Page 4 of 6 I". It consists of portion of fibroadipose tissue and submandibular gland measuring 4.5 x 3.7 x 2.4 cm. The submandibular gland measures 3.7 x 2.5 x 1.2 cm and is unremarkable. Multiple lymph nodes ranging from 1.0 to 1.5 cm are identified. Representative sections are submitted. 5A submandibular gland 5B two lymph nodes 5C one lymph node 6. The specimen is labeled the patient's name and "Soft Tissue: Right partial glossectomy and right partial mandibulectomy-. ". It consists of an oriented portion of right tongue, floor of mouth, and a segment of mandible with overall dimensions of 4.3 SI x 6.5 ML x 6.0 AP cm. The tongue measures 5.5 x 3.5 x 1.1 cm. The floor of mouth measures 4.7 x 2.0 x 0.5 cm. The mandible consists of. the body and ascending ramus and measures 7.5 by 3.0 x 0.8 cm. The mandible contains one tooth. There is an ill-defined tumor involving the tongue, and floor of mouth . The tumor measures 3.2 x 2.2 x 1.2 cm. The tumor is solid,. and has a yellow-tan cut surface. No invasion of bone is identified. It is  located at 0.3 cm from the lateral margin, 2.0 cm from the medial margin, 0.8 cm from the deep margin, 0.3 cm from the anterior margin, and 1.2 cm from the posterior margin. A representative section of tumor with deep margin is submitted for frozen section. The deep/medial margin is painted with silver. nitrate and India ink. The distance from the tumor to the is 0.8 cm. Two pieces of tumor and normal tissue were taken for the tissue bank. Sections of. bone are taken for decalcification. Representative sections are submitted. 6A frozen section control. 6B anterior margin 6C lateral margin 6D posterior margin 6E medial margin 6F-6H tumor with deep margin 6I tumor 6J normal tongue 6K anterior mandible margin. 6L posterior mandible margin 6M-6O mandible closest to tumor 7. The specimen is labeled with the patient's name and "Neck: Left neck, level I, II". It consists of portion of fibroadipose tissue and submandibular gland measuring 6.0 x 5.0 x 2.5 cm. The submandibular gland measures 4.8 x 3.5 x 1.8 cm and is unremarkable. Multiple Iymph nodes ranging from 0.3 to 1.5 cm are identified. Representative sections are submitted. 7A submandibular gland 7B multiple lymph nodes level I
+
+--- Page 5 ---
+Page 5 of 6 7C multiple lymph nodes level II 8. The specimen is labeled with the patient's name and "Oral Cavity: Left floor of mouth. :". It consists of a fragment of tissue measuring 2.5 x 0.2 x 0.1 cm. The specimen is submitted in toto for frozen section. 8A frozen section control 9. The specimen is labeled with the patient's name and "Soft Tissue: Left sublingual gland  ". It consists of a fragment of tissue measuring 1.7 x 1.5 x 0.7 cm. The specimen is submitted in toto for frozen section. 9A frozen section control 10. The specimen is labeled with the patient's name and "Soft Tissue: Left .ventral tongue-  ". It consists of a fragment of tissue measuring 2.0 x 0.2 x. 0.2 cm. The specimen is submitted in toto for frozen section. 10A frozen section control 11. The specimen is labeled with the patient's name and "Soft Tissue: Deep tongue margin". It consists of a fragment of tissue measuring 0.4 x 0.3 x 0.1 cm. The specimen is submitted in toto for frozen section.. 11A frozen section control 12. The'specimen is labeled with the patient's name and "Soft Tissue: Right tongue margin. - ". It consists of a fragment of tissue measuring 1.5 x 0.5 x 0.3 cm. The specimen is submitted in toto for frozen section. 12A frozen section control 13. The specimen is labeled with the patient's name and "Soft Tissue: Deep midline muscle-  ". It consists of a fragment of tissue measuring 1.6 x 0.7 x 0.6 cm. The specimen is submitted in toto for frozen section. 13A frozen section control 14. The specimen is labeled with the patient's name and "Surgical Waste". It consists of four pieces of unremarkable yellow-tan bone tissue with minimal soft tissue ranging in size from 1.5 x 0.7 x 0.2 cm to 6.5 x 2.0 x 1.2 cm. No sections are submitted for microscopic examination. QUICK SECTION 6A. Right glossectomy specimen; deep margin (taken with surgery fellow); - Squamous cell carcinoma, present more than 0.5 cm from inked deep margin.. 8A-13A. Margins (left floor of mouth, left sublingual, left ventral tongue, deep tongue, right tongue, deep midline muscle);. - Negative for malignancy.. Called at Addendum Status: Signed Out
+
+--- Page 6 ---
+Page 6 of 6 Addendum Comment Decalcified sections of the mandible show invasion of cortical bone by squamous cell carcinoma. The bone margins are negative for carcinoma..
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diff --git a/output/text/b0a86a2e-0cec-4249-9c42-9a845df50515.txt b/output/text/b0a86a2e-0cec-4249-9c42-9a845df50515.txt
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index 0000000000000000000000000000000000000000..e9b68cb45ae63f94f2ed0824b34a4df2cb37d596
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+
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+1Cs -0-3 Collection Date: 850 S1K: Bnast, Nos C50.9 UUID:F70DE761-F081-4F4C-AD22-9A166CF78CA8 TCGA-BH-A1F5-01A-PR Redacted PATIENT HISTORY: The patlent is a  -old female. Date of last menstrual period: Not given. PRE OP DIAGNOSIS: Breast cancer. POST OP DIAGNOSIS: Same. PROCEDURE: Right sentinel node biopsy, right segmental mastectomy.. FINAL DIAGNOSIS: Part 1: Right SentineL Lymph NOde #1, BIOpsy - One Lymph noDe, negative for tumor (0/1). Part 2: Right nOn-sentinel Lymph noDe #2, BiOpsy -- FIBrOaDipose tissue, nO Lymph noDe identifieD. Part 3: Right non-sentinel Lymph node #1, BiOpsy -- ONE LYmPH NODE, NEGATIVE FOR TUMOR (0/1). PARt 4: Right nON-SEnTIneL Lymph nODE #3, BIOpSy --  ONE LYMPH NODE, NEGATIVE FOR TUMOR (0/1). Part 5: Right Sentinel Lymph nODe #2, bIOpsy - One Lymph nODE, nEGAtiVE FOR TUmOR (0/1). Part 6: Right SentineL Lymph nOde #3, biOpSy -- ONE LyMPH nODE, NEGATIVE FOR TUMOR (0/1). Part 7: Right breast, Biopsies x 4 - A. ONE OUt OF 4 Lymph nODeS POSITIVE fOR mEtAStaTIC CARCInOmA (1/4). 8. Benign FibroaDipOse tissue (see comment). Part 8: Right breast, segmental mastectomy - A.  Infiltrating Duct CarcinomA. 1.4 Cm in greatest Dimension As measured On the SliDe, NOTTiNGHAm SCORE 7/9 (TUBULES 3, nUCLEI 3, MITOSIS 1) ASSOC!ATED WITH MICROCALCIFICATIONS. B. LYMPHOVASCULAR INVASION IDENTIFIED. C. DUctal CARcinoma In SiTU, SOLid And CriBrifORm typE, nUcleaR GRADe 2 aSsOciated wiTH MICROCAI FICAT!ONS AND COMPRISING LESS THAN 5% OF TUMOR. D. SURGICAL MARGINS NEGATIVE. INFI DUCT CARCINOMA APPROACHES ANTERIOR MARGIN WITHIN O.3 CM.E F. Changes Consistent with previous core Biopsy Site. G TumOR iS eStROgen RECeptOR POsItive, PrOgeSterOne rEcEptOr PosITJye AnD hER-2/NeU NegaIye as per previous core biopsy report. H. UNREMARKABLE SKIN. I. FIBROCYSTIC CHANGES. COMMENT: One lymph node in specimen number 7 contains micrometastatic carcinoma that measures iess than 0.2 cm in diameter.
+
+--- Page 2 ---
+MICROSCOPIC: SYNOPTIC : PRIMARY iNVASIVE CARCINOMA OF BREAST A. Laterality: 1 1. Right 2. Left B. Procedure: 1 1. Segmentectomy 3. Modified radical mastectomy 2. Simple mastectomy 4. Re-excision C. Location:  1. Central subareolar 4.L0Q 2. U0Q 5.LIQ 3. UIQ 6. Not specified O. Size of tumor (maximum dimension invasive component by gross or microscopic exam): 1.4 cm E. Type (invasive component): 1 1. Ductal, NOS 5. Cribriform 9. Metaplastic 2. Tubular 8. Papillary 10. Other 3. Mucinous 7. Lobular 4. Medullary 8. Carcinoid like F. if lobular carcinoma, specify type:  N/A. 1. Classical 4. Signet ring 7. Pleomorphic 2. Solid 5. Trabecuiar  3. Alveolar 6. Tubulobular G. Nottingham Score:e G1. Nuclear grade: 3 G2. Tubule formation: 3 G3. Mitotic activity score: 1 G4. Total Nottingham score: 7 G5. Nottingham grade (1, 2, 3): # H. Angiolymphatic invasion: 2 1. No 2. Yes I. Dermal lymphatic invasion: 2 1. Yes 2. No 3. Not applicable J. Calcification: 3 1. No 2. Yes -- benign zones 3. Yes -- malignant zones K. Type of in situ component: 1/2 1. Cribriform 4. Micropapllary 7. Lobuiar 2. Solid 5. Apocrine 3. Papillary 6. Comedo .  Percentage of tumor occupied by in situ component: 5% M. Surgical margins involved by invasive component: 1 1 No 2. Yes -- focal 3. Yes -- diffuse N. Surgical margins involved by in situ component: 1 1. No 2. Yes -- focal O. Paget's disease of nipple: N/A 3. Yes - diffuse 1. Yes 2. No P. Number of positive lymph nodes:1 Q. Total number of lymph nodes examined: 9. R. Sentinel node metastasis: 2 1. Yes 2. No S. Only micrometastases to lymph nodes (none larger than 0.2 cm): 1 1. Yes 2. No T. Metastasis/es to a lymph node 2 cm. or more in greatest dimension: 2 1. Yes 2. No U. Lymph node metastasis/es with extracapsuiar extension: 2 1. Yes 2. No V. Metastases to ipsilateral internal mammary lymph node (if applicable): N/A 1. Yes 2. No W. Skin invoived (ulceration): 2 1. Yes 2. No X. Non-neoplastic breast tissue: 6 1.ADH 4. Fibroadenoma 2. ALH 7. LCiS  5. Papilloma 3. Radical scar 8. Other 6. FCD Y. Multicentricity/multifocality of invasive foci:2 1.Yes 2.No Z. TNM stage: T1c N 1mi M X
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diff --git a/output/text/b0a8ca03-864a-46e3-bacd-470b0fe353e3.txt b/output/text/b0a8ca03-864a-46e3-bacd-470b0fe353e3.txt
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+1cD-0-3 Caruinms, ursthebial, Nos 812013 Situ: b1nddwr Nos C67.9 1/28/1 M Diagnosis 1. Carcinoma infiltrates in four of seven lymph nodes, right (4/7). 2. Four tumor-free lymph nodes, left (3/4). 3. Soft tissue with extensive infiltrates of a poorly differentiated urothelial carcinoma. 4. Poorly differentiated urothelial carcinoma of the bladder with infiltration of all parietal layers, including the perivesical fatty tissue extending as far as the surgical preparation margin, the right seminal vesicle and the right ureter. Multifocal invasion of the lymph and blood vessels. Dysplasia of preserved urothelial sections.. Prostate shows infiltrates of a poorly differentiated adenocarcinoma of the prostate on both sides that is confined to the organ, above all in the right peripheral area (Gleason 4+5-9). Gleason 4: 40%; Gleason 5: 30%. The few parts showing Gleason 3 pattern are by definition not included in the final Gleason score. Maximum tumor size 0.9 cm.. Tumor classification of urothelial carcinoma: pT4b, L1, V1, R1, pN2 (4/11). Comment In the previous frozen sections, parts showing carcinoma in situ were still found in the area of the right ureter resection margin. The follow-up resection material was free of tumor and dysplasia. But infiltration of the pelvic wall and involvement of the cystectomy preparation margin gave R1 status. UUID:27D0A4B2-0CC8-46CB-8048-2A802805A100 -C4-A0F7 7-01A-PR
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diff --git a/output/text/b0b8c716-85ec-4481-a335-239b4ff22ce9.txt b/output/text/b0b8c716-85ec-4481-a335-239b4ff22ce9.txt
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index 0000000000000000000000000000000000000000..34690b2729ef23e248a5ca218bfec885b1eea25f
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+--- Page 1 ---
+P.22/33 Nr! Sreast. Left. total Mastectomy  A. cLOBDEAr NeOpLASiA (AtypICAl LObULar hypeRpLASia) (sec comment). B. Fibroadenoma, dOctal epIthelial hypeRplasia, fibrocystic change. Skin and nipple, no tumor seen. Part 2: breast, Right, total mastectomy -- A.  Infiltrating Ductal carcinoma, nos type, moderately Differeniiateo. The Tumor is-multIfocal. mulTiCentric, LocateD at The Junction Of ijpper Outer Quadrante (UoQ) And UpPEr inner QUadrant (uIQ) As Well As In The Upper Outer Quadrant (uOQ). C. the Tumor noduLes mEasure 2.5 cm (GrOs8 measurement) and 0.5 cm (mIcrOscOpiC MEASUREMENT) RESPECTIVELY D. NOTTiNgham sCORE 6/9 (TUBULeS 2, NUcLeaR GRADe 2, MITOSiS 2),OVERALl GRaDe 2/3. E.  NO DEFINITIVE LYMPHOVASCULAR INVASION IS IDENTIFIED. F. DUcTAL CARcInOma IN 8ITU, SOLiD TYPe WiTh COmedO nEcrOSIS, nUCLEAR GRADE 3 . wITH LObuLAr exTensiOn. cOmprising 2s% Of the totaL tumOr vOLume And is Present in AssOciaTIOn And Away From the Invasive CarcinOmA. G.  mArgin3: Deep And AnteriOr margisn Of resection Are free Of invAsive As weLl as In Situ Carcinoma, CLosest Anterior margin is 7mm AwAy. H. A1'ypical Ductal hyperpLAsia. previous BiOpsy site Changes (#1 And #2), ( See comment-2).  Fibroadenoma, pseudoangiomatous stromal hyperfLasia (pash), columnar ceLl. change Skin ann nipple, no tumor seen. K. ER.PosItIvE, Pr-pOsITivE. nEr 2/neU -StrOngly POsitive (IhC 3+ As wELL As FiSk-AmPLiFicaTIOn}. CROSS REFER Part 3: #1 Sentinel LyMph node, Right axiLLA, Biop$y --  One Lymph nOoe with metastatiC carcinoma, the metastaTic fOcUs measures 6mm (On gLASs SLIDE) . FOCAL EXTRACAPSULAR EXTENAION IS IDENTIFIED (1/1). 1Cs-0 -3 Part 4: #2 3Entinel Lymph noDe, R!ght AxILLA, BiOpsy.- One benign i.ymph nooe, no tumor seen (0/1). Cancnoms, mf1t^sty ductrl, n0s 85oof3 Sih : brst, Nos c50.9 313 PArT 5: #3 SEnTinel LympH nODE, RighT AXILLA_ BiOp8Y --  One Benign lymph nope, no tumor seen (o/1). PaRt 6: #4 SENTIneL LympH NODE, RIght AXILLA, BIOpSy - One benign lymph node. no tumor seen (d/1). Part 7: non-sentinel Lymph node, right Axilla, Biopsy --  One benign Lymph node, no tumor 5een (0/1). Jinvrois: SyNOPTiC - PRImARy iNVASIVE CARCINOmA OF BREAST LAteraLity: Procedure: Riah LocaTiOn: Simpht; Inestactomy Upper outer quadrant SIZE OF TUMOR: Uppe: inner qusdrant MUL TICENTRICITY/MULTIFOCALITY OF iNVASIVE FOCI: Maxinum dinersion Invasive componcnt: 2 5 cnt TUmOR AGgREGATE SIZE: Yes TUMOR TYPE (invasivc compoitnt): Suin ot tne sizes of mulliple invasive tumors: 3.0 cm nOttingham scOre: Ductal adenocarrinume. NoS Nucloar giude: 2 Tubule formation 2 UUID:16DE55CE-076E-43D3-84BD-332A79895EFD Milotle acuvily uxre 2 tCGA-BH-A0DZ-01A-PR Total Nottingham :core: G 'Redacted ANgIOLYMPMATIC INVASION:S Nnttingham grade (1. 2, 3): 2 DERMAL LymPHATIC iNVASION:E Nn CALCIFICATION: No Tumor type, In situ: Yes, rnallgnant zones Solid Cnmedo Dris admixes! und outsirto of Invasive carglnoma compunen! SURGICAL MARGINS iNVOLVED By iNVASIVE COmPONENT: Percent of t nnor occuphied by In itu component: 25 % SURg MARGINS InVOLVED Ay In SITU COmPONENT: Na Pagets Disease of nipplE: No Lymph nodes positive: No Critarla Lymph nodes Examined: 1 methOd(s) Of LymPh nODE exAminatiOn: SENTINEL NODE METASTASIS:  H/E stain ONLY KeRATIN POSITiVE CELLS ARE PRESENT: Yat SIZE OF NODAL mETASTASES: Niy LymPh nODE metASTASiS(-E8) WITH extRACAPsULAR ExTenSIOn: Diamcter of laryest lymph node mctaslasin' 6 mm METASTASES TO IPSILATERAL INTERNAL MAMMARY LYMPH nODE (IF APPLICABI.E): Yes Skin involVeD (ULCeraTIOn): No t stage, patholocic: No N stage, patholocic. p12 M Stage, pathologic: DN1 Estrogen receptors. pMX poRtive progesterone receptors: HER2/NEU: ponitive 3+ ..
\ No newline at end of file
diff --git a/output/text/b0ca338a-31ab-4824-9919-1d39e390687a.txt b/output/text/b0ca338a-31ab-4824-9919-1d39e390687a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6cafdd3956a9e3cd6eb6e713a45ea193e0347d02
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+
+--- Page 1 ---
+ClinicalCase Report (For Collection of Cancerous Tissue) Informed Consent I personally informed this natient that a specimen(s) would be collected to be used for research purposes.Ireviewed the RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator Clinical Information GENERAL INFORMATION Date of Birth mm/dd/yyyy Height Marital Status Race Temperature Single Married Gender Weight Divorced Widow Blood Pressure Heart Rate HISTORY OF PRESENT ILLNESS Chief Complaints: wwer.cbdominal pain j deuer Symptoms: weioyht Ls5 Clinical Findings: Performance Scale (Karnofsky Score): 100Asymptomatic 80-90 Symptomatic but Fully Ambulatory 60-70 Symptomatic,in bed less than 50%of day 40-50Symptomatic,in bed more than 50% of day.but not bed ridden 20-30 Bed Ridden CURRENT MEDICATIONS Drug Dose Route Frequency Date (mm/dd/yyyy To To / To / / To / I To
+
+--- Page 2 ---
+PAST MEDICAL HISTORY Diagnosis/Disease/Disorder/Injury Diagnosis Date Treatment Status SOCIAL HISTORY Occupation: Environmental Hazards: Smoking History Current Status TYPE Packs/day Duration When Quit YES NO (yrs) (yr) Alcohol Consumption Current Status TYPE Drinks/day Duration When Quit YESNO (yrs) yr Drug Use Current Status TYPE Frequency Duration When Quit YESNO yrs) yr FAMILYMEDICAL HISTORY Relative Diagnosis Age of Diagnosis LABDATA Test Result Test Result Date Dote HIV Negative Positive: CEA Negative Positive: Hep B Negative Positive: CA15-3 Negative Positive Hep C Negative Positive: CA19-9 Negative Positive: AFP Negative Positive: PSA Negative Positive: Other: Other: Negative Positive: Negative Positive B/TCell Markers: 2
+
+--- Page 3 ---
+DIAGNOSTIC STUDIES Study Results Date Ultrasound X-Ray CT EndoscopyyA tmowr was dounc in the deendin leln MRI Biopsy CLINICAL DIAGNOSIS Preoperative Clinical Diagnosis CoON CANCER Location of Suspected Involved Lymph Nodes Location of Suspected Distant Metastasis Clinical Staging Date of Diagnosis T3NOM Stage:TA 0 Treatment Information SURGICAL TREATMENT Procedure Date of Procedure D Hemscalleetoony Primary Tumor Organ Detailed Location Size Celen HimoR peg eenaug 3x2x.2cm Extension of Tumor Lymph Nodes Description Location of Lymph Nodes # of Lymph Nodes Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Organ Detailed Location Size Surgical Staging T3 No MO Stage: NEOADJUVENT THERAPY (Chemo,Radiatign, Immuno, Hormonal, or Molecular) Drug/Treatment Dose Route 'Frequency Date (mm/dd/yyyy) To / / To To / To To 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by: Date ime Preserved by: Dat ime SPECIMEN TYPE (#of samples provided) Frozen Blood/Serum/Plasma Slide Paraffin Block Diseased Normal Diseased Normal Diseased Normal Diseased Normal 4 2 2 Time to LN2 Time to Formalin Time to LN2 12 min 13 min min PATHOLOGICAL DESCRIPTION PrimaryTumor Organ Size Extension of Tumor Distance to NAT Celom Tmor 6 3x2x2 cm cm Lymph Nodes Location #Examined # Metastasized Distant Metastasis Organ Detailed Location Size Pathological Staging pT 3 Nb MO Stage:I4 Notes: 4
+
+--- Page 5 ---
+ONSOLIDATED DIAGNOSTIC PATHOLOGY FORM* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION Diffuse + STRUCTURAL PATTERN Mosaic Streaming X Necrosis Storiform Lymphocytic Infiltration Fibrosis Vascular Invasion Palisading Clusterized X Cystic Degeneration Alveolar Formation X Bleeding Myxoid Change Indian File Psammoma/Calcification 2.Cellular features: Squamous + Adenomatous + Sarcomatous Squamoid Cell + Lymphomatous Glandular cell Round Cell Spindle Cell Large Cell Cell Stratification Fibroblast Keratin Small Cell Secretion Osteoblast RS Cel/RS Like Desmosome Intracyt.Vacuole Lipoblast Inflam.Cell Pearl Gland formation X Myoblast Plasma Cell Otherwise Specified: D248 D4407 Du40 Neesen 2.Cellular Differentiation. Well Moderately Poor Nuclear Atypia: 3. Nuclear Appearance Aniso Nucleosis Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity Nuclear Grade X Histological Diagnosis:_AdelsaeingC MiAoee tbse nd/NRejeetea Comments: PATHOLOGIST STAFF FOR RESEARCH USE ONLY). #(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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diff --git a/output/text/b0cf7455-4ca2-4196-9742-a26136d2707e.txt b/output/text/b0cf7455-4ca2-4196-9742-a26136d2707e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e3b50f9eb2e732adaba7bb9731aaf7051025b47f
--- /dev/null
+++ b/output/text/b0cf7455-4ca2-4196-9742-a26136d2707e.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+TCGA-AL-3471 SURGICAL PATHOLOGY REPORT Clinical History/Diagnosis: Right Kidney Mass. Source of Specimen(s): right Kidney resection with Adrenal gland Gross Description: Received in one part. Source of Tissue: 1. Labeled #1, "right kidney'. Frozen Section Diagnosis: 1FS- PAPILLARY RENAL CELL CARCINOMA PER Gross Description: Received fresh labeled ",. right kidney". It consists of a 460 gram right nephrectomy consisting of a kidney measuring 10.5 x 6 x 6 cm and perinephric fat measuring from 1 up. to 5 cm from point of attachment. Dissection through the fat discloses no lesions, masses or nodal tissue. There is an area of fullness in the lower pole of the nephrectomy. At the hilum there is a 0.5 cm of ureter.. The right ureter is opened and has a pin point lumen. The vascular margin. is also unremarkable. The kidney is bivalved disclosing a soft. predominantly necrotic mass in the lower pole that measures 4.4 x 3.5 x. 3.5 cm. The lesion compresses the inferior calcyx. The tumor is soft, necrotic, brownish-orange in color and towards the periphery there is some. more solid possible viable Iesion. Representative sections from areas to include possible lesion is submitted for frozen section in 1FS. The capsule and fat overlying the tumor are intact with no areas suspicious for invasion. Elsewhere the parenchyma is normal with the usual cortico-medulary junction present. Gross Photographs are Taken.. Designation of Sections: 1A- vascular and ureter margin, 1B- tumor in relationship to calyceal system, 1C-1E- tumor, 1F-1G- tumor with overlying. fascia and capsule, 1H- uninvolved right kidney, 1I- perinephric fat Note: Tissue is procured and sent for Cytogenetic Studies.. ************************ Final Diagnosis: 1. Right kidney: -Low gradd papillary renal cell carcinoma (type 1) - 4.4 cm tumor is limited to kidney.. --No lymphovascular invasion is identified. - Margins are negative for tumor..
+
+--- Page 2 ---
+ No lymph nodes are identified - Uninvolved kidney shows scattered globally sclerotic glomeruli.. - pT1bNxMx Procedures/Addenda FC Cytogenetics Solid Tumor Results-Comments CYTOGENETIC ANALYSIS REPORTS DIAGNOSIS: Papillary Renal Cell Carcinoma KARYOTYPE: Abnormal karyotype: 42 46,X,-Y,+2,+3,-4,+8,+16,+17,+20[cp9] One cell also contained an extra copy of chromosome 7 among other numerical changes. RESULTS: The renal mass was harvested after seven and nine days in. culture. Only nine metaphases could be found in a scan of ten slides.. The chromosomes from these metaphases were counted and analyzed, and four of the metaphases were karyotyped by G-banding. All the cells contained numerical chromosome abnormalities that are listed in the karyotypic. description above. The extra copies of chromosomes 16, 17, and 20 and the. missingchromosome have all been reported in papillary renal cell. carcinoma (PRCC). Although only one cell contained an extra copy of. chromosome 7, this is a significant finding in PRCC.
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diff --git a/output/text/b0f8a78e-27f9-4a2e-9e1f-c6833c661b5b.txt b/output/text/b0f8a78e-27f9-4a2e-9e1f-c6833c661b5b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3dcf370f0a20018a00e7f73b83d2dce0e598ac87
--- /dev/null
+++ b/output/text/b0f8a78e-27f9-4a2e-9e1f-c6833c661b5b.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:7C291BB4-B97B-4EE1-BEB2-3B05FABD24E2 TCGA-AD-ASE3-01A-PR Redacted SURGICAL PATHOLOGY: PROCEDURE DATE: RECEIVED DATE: xcD-o-3 COPY TO: Adenocarcinomo, NsS 8/4s|3 Site: Colon, Ceeum C18,D JsD12/2 4j1z Pre-Op Diagnosis Right colon cancer Post-Op Diagnosis Same as above Clinical History Nothing indicated Gross Description: Received in a single container labeled ".  - right colon and terminal ileum" is a 23 cm previously opened portion of large bowel including cecum, as well as 8 cm of attached previously opened terminal ileum. The specimen is covered by a moderate amount of pericolic and epiplaic adipose tissue in which a 8.4 x 0.8 x 0.8 cm. grossly unremarkable vermiform appendix is identified. The visible serosa is focally shaggy and tan pink with a few fibrofatty adhesions. Noted at a point approximately 9 cm from the distal margin is a 3.3 x 3.2 cm area of indurated umbilication of the serosa. The specimen has been received after tissue harvest for genomic study.  Within the specimen container are three tissue cassettes each labeled The bowel wall is up to 0.6 cm edernatous and fibrotic. The lumen is lined by tan pink mucosa. with preservation of intestinal folds. In the area corresponding to the umbilication at a point 8.6 cm from the distal margin and 3.8 cm. from the ileocecal vaive is a partially sectioned 9.2 x 7.5 cm plaque like finely granular centrally ulcerated tan pink lesion with raised rolled borders. This has a gritty gray tan fibrotic cut surface measuring up to 3.2 cm in thickness. The lesion grossly extends through the muscularis but is limited by the serosa in the area away from the pericolic fat. In the area of the pericolic fat. the lesion grossly appears to focally extend through the wall into the adipose tissue where it is seen at its nearest point approximately 0.9 cm from the nearest outer surface margin. The lesion is noted within 0.1 cm of the outer surface in the area of.
+
+--- Page 2 ---
+the serosa. Noted scattered along the length of the bowel are a few additional tan gray polypoid excrescences up to 0.8 cm which are unfixed to the undertying muscularis. On sectioning the surrounding adipose tissue reveals multiple poorly defined fleshy tan pink to. yellow nodules up to 1.5 cm. Representative sections are submitted labeled as follows: A - proximal margin; 8 - distal margin; C-G representative lesion and surrounding tissue; H - representative polyps; I - random uninvolved bowel; J - appendix; K-N - individual. pericolic nodules bisected; O-R - whole smaller pericolic nodules. Microscopic Description: The slides labeled?  are examined. See diagnosis.. Final Diagnosis Distal ileum, appendix, and right colon (right colectomy):. Tumor characteristics: Tumor site: Cecum. Size:  9.2 cm in greatest diameter. Macroscopic tumor perforation: Not identified. Histologic type:  Adenocarcinoma. Grade: Moderately differentiated. Microscopic tumor extension: Carcinoma extends through muscularis propria into subserosal adipose tissue. Margin Status: Proximal margin: No carcinoma identified. Distal margin: No carcinoma identified. Circumferential radial/mesenteric margin: No carcinoma. identified. Distance of tumor from closest margin: 1 mm from the. circumferential radial margin.. Treatment effect:Unknown.. Lymphovascular space invasion: No unequivocal lymphovascular space invasion identified.. Perineural invasion: Not identified. Presence of mesenteric tumor deposits: Not identified. Lymph Node Status: Total number of lymph nodes examined: 32 Total number of lymph nodes containing metastatic carcinoma: Zero (0/32) PAS 9 Other findings: Scattered foci of lymphoid aggregates. PAS 6 Scattered hyperplastic polyps. PAS 4 Appendix: No carcinoma is identified. PAS 1 SPC-A. Stage: pT3N0 Comments At the request of the undersigned pathologist, these slides have been additionally reviewed by Dr.   who concurs with the diagnosis. Cricaia This report has been finalized at the y Tumor Ste Discrepac
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diff --git a/output/text/b113904a-5049-4c6a-a48e-f8cb14e0cf58.txt b/output/text/b113904a-5049-4c6a-a48e-f8cb14e0cf58.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9f6e9993cd9b4024b86f2cb445cecd8ed4532488
--- /dev/null
+++ b/output/text/b113904a-5049-4c6a-a48e-f8cb14e0cf58.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Ics-0-3 Casci rms, mfiAtnsting 1osuby N0s 8520f3 S'rte: buast c50.9 Nos pw 5/q|1 UUID:15237FF6-A56E-4E05-B81D-887E91859917 TCGA-D8-A27T-01A-PR Redacted page 1 / 2 copy No. Date: Examination: Histopathological examination Internal invoice No. Value of diagnostic procedure Examination No.: Patient: XXX PESeL: XXX Age: Gender: F Material: Multiple organ resection -- right breast : Unit in charge: Physician in charge: Material collected on: : 4aterial received or m/s97r~5[+$Htr Expected time of examination: up to 8 working days Clinical diagnosis: Examination performed or Macroscopic description:  Right brea$t sized 21.5 x I4 x 4 cm removed without axillary tissues and with a skin flap of 15 x 7 cm. Tumour sized 3.0 x 1.4 x 1.8 cm on the boundary of outer quadrants, located 3 cm from the lower boundary, 3 cm from the base and 1 cm from the skin. Microscopic description: Carcinoma mammae invasivum- NHG2 (3+2+1:5 mitoses/10 HPF - visual area: 0.55mm). Lesions of the type mastopathia fibrosa et cystica. Metastases carcinomatosae in lymphonodis. Infittratio capsulae iymphonodi et telae perinodalis. Histopathological diagnosis: Invasive lobular carcinoma of the right breast  Compliance validated by: Examination performed on Results of immunohistochemical examination: Estrogen receptors found in over 75% of neoplastic cell nuclei.  Progesterone receptors found in over 75% of neoplastic cell nuclei. HER2 protein stained with Ventana's Pathway HER-2/neu (485) Rabbit Monoclonal Antibody. Negative reaction in invasive cancerous cells (Score=1+). Compliance validated by Examination performed on:
+
+--- Page 2 ---
+page 2 / 2 Examination: Histopathological examination. Examination No.: pEsEL: XXX Gender: F Patient: XXX Examination performed on: Examination result: Carcinoma lobulare invasivum mammae dextrae. Metastases carcinomatosae in Iymphonodis axillae (No II/Il) (NHG2, pT2, pNla). Following immunohistopathological tests were made:: E - cadheryna "-".. Comoliance validated hu
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diff --git a/output/text/b1519d7c-8aec-4ac7-93c3-b2308dc69574.txt b/output/text/b1519d7c-8aec-4ac7-93c3-b2308dc69574.txt
new file mode 100644
index 0000000000000000000000000000000000000000..966a13a736ce8fbf8748707f3c5cb946e2f829ce
--- /dev/null
+++ b/output/text/b1519d7c-8aec-4ac7-93c3-b2308dc69574.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+Specimen(s) Received 1. Oral-Cavity: Right marginal mandibulectomy - suture posterior 2. Oral Cavity: Right anterior margin 3. Oral Cavity: Right medial margin QS 4. Oral Cavity: Right anterior margin-QS. 5. Oral Cavity: Right posterior margin QS 6. Oral Cavity: Right lateral margin QS 7. Oral Cavity: Right deep'muscle margin QS 8. Neck: Right level 1A 9. Neck: Right level 1B 10. Neck: Right leve! 2A 11. Neck: Right level 3 & 4 12. Surgicat Waste. Diagnosis 1. Right marginal mandibulectomy:. - In-situ and invasive squamous cell carcinoma, moderately differentiated.. a.  Maximum tumour dimension 1.8 cm.. b. No perineural invasion present.  No lymphovascular invasion present. C. d. Anterior margin positive for squamous carcinoma in-situ (CIS). All other margins are negative for in-situ and invasive carcinoma.. t. Bone sections pending decalcification and will be reported in an addendum. 2. Right anterior margin: - In-situ and focally invasive squamous cell carcinoma. a. Squamous carcinoma in-situ (CIS) is present at the mucosal margin. b.  Bone sections pending decalcification and will be reported in an addendum.. 3. Right medial margin: - Squamous mucosa, negative for tumour. 4. Right anterior margin: - Positive for squamous carcinoma in-situ (Cis). No invasive carcinoma present. 5. Right posterior margin:. - Squamous mucosa, negative for tumour. 6. Right lateral margin:. Page 1 of 4.
+
+--- Page 2 ---
+Surgical Pathology Consultation Report - Squamous mucosa, negative for tumour.. 7. Right deep muscle margin:. - Skeletal muscle, negative for tumour.. 8. Right neck; level IA: - Twelve lymph nodes, negative for tumour (0/12). 9. Right neck; level IB:. - Three lymph nodes, negative for tumour (0/3). - Submandibular gland with no pathologic changes.. 10. Right neck; level lIA:. - Two lymph nodes, negative for tumour (0/2). 11. Right neck; levels III & IV:. - One lymph node, negative for tumour (0/1). 12. Surgical Waste: - Skin with no pathologic changes (gross examination only) Clinical History oral ca Gross Descriptlon 1. The specimen container labeled with the patient's name and as "right marginal mandibulectomy", contains one piece of right floor of mouth mucosal tissue measuring 4.0 cm Sl x 3.0 cm ML x 5.5 cm AP. It includes a portion of upper posterior mandible body with 1 tooth. There is a tumor arising on the mucosal surface. The tumor measures 1.5 cm Sl x 1.5 cm ML x 1.8 cm AP. The tumor is elevated. There is no involvement of bone by the tumor. The turmor is located at 0.7 cm from the closest anterior margin. Remaining margins are as follows: Medial 1.0, posterior 1.8, lateral 1.8 cm respectively The resection margins are painted with silver nitrate. On sectioning, a small portion of gland measuring 0.8 x 0.4 x 0.4 cm are included in the submucosa anterior-medial part of the specimen. Three pieces of tumor and three pieces of mucosa are taken by tissue bank. Representative sections are submitted as fotlows: 1A-1D mucosa with anterior margin, from lateral to medial. 1E-1l mucosa with medial margin, from anterior to posterior. 1J-1M mucosa with posterior margin, from medial to lateral. 1N-1P mucosa with lateral margin, from posterior to anterior. 1Q center of tumor with no margin. 1R mandible bone, anterior margin, en face. 1S, 1T mandible bone, closest to mucosal tumor. 1U mandible bone, posterior margin, en face. 2. The specimen container labeled with the patient's name and as "right anterior margin", contains one piece of mucosa tissue measuring 2.7 cm SI x 2.5 cm ML x 1.0 cm AP. It includes a portion of mandible bone with one tooth. The posterior resection margin of the this piece of mandibular bone matches the anterior resection margin of the mandibular bone of specimen 1. No tumor is identified in this specimen.. Representative sections are submitted as follows: 2A-2C mucosa submitted in total, all sagittal sections, from lateral to medial, with anterior margin painted with India ink 2D anterior margin of bone, en face Page 2 of 4
+
+--- Page 3 ---
+Surgical Pathology Consultation Report. 3.The specimen container labeled with the patient's name and as "right medial margin", contains one piece.of mucosa tissue measuring 2.0 x 0.3 x 0.2 cm received in fresh. This is examined at intraoperative consultation by frozen section performed on the entire specimen. 3A frozen section resubmitted. 4.The specimen container labeled with the patient's name and as "right anterior margin", contains one piece of mucosa tissue measuring 0.6 x 0.2 x 0.1 cm received in fresh. This is examined at intraoperative consultation by frozen section performed on the entire specimen.. 4A frozen section resubmitted. 5.The specimen container labeled with the patient's name and as "right posterior margin", contains one piece of mucosa tissue measuring 1.7 x 0.2 x 0.2 cm received in fresh. This is examined at intraoperative consultation by frozen section performed on the entire specimen. 5A frozen section resubmitted. 6.The specimen container labeled with the patient's name and as "right lateral margin", contains one piece of mucosa tissue measuring 1.8 x 0.2 x 0.2 cm received in fresh. This is examined at intraoperative consultation by frozen section performed on the entire specimen. 6A frozen section resubmitted. 7.The specimen container labeled with the patient's name and as "right deep muscle margin", contains one piece of muscle tissue measuring 1.5 x 1.0 x 1.0 cm received in fresh. This is examined at intraoperative consultation by frozen section performed on the entire specimen.. 7A frozen section resubmitted. 8. The specimen is labeled with the patient's name and "right neck level 1A". It consists of portion of fibroadipose tissue measuring 3.5 x 3.0 x 1.2 cm. Multiple lymph nodes ranging from 0.3 to 1.4 cm are identified.  Representative sections are submitted as follows: 8A the largest lymph node bisected. 8B, 8C multiple lymph nodes 9. The specimen is labeled with the patient's name and "right neck level 1B and". It consists of portion of fibroadipose tissue measuring 4.5 x 3.5 x 1.8cm. One submandibular gland measuring 4 x 3 x 1.8 cm is identified. Multiple lymph nodes ranging from 1.0 to 1.6 cm are identified. Representative sections are submitted as follows: 9A the largest lymph node bisected 9B two lymph nodes. 9C one representative section of submandibular gland. 10. The specimen is labeled with the patient's name and "right neck level 2A". It consists of portion of fibroadipose tissue measuring 3.0 x 3.0 x 1.2 cm. Two lymph nodes ranging from 0.7 to 0.8 cm are identified. Representative sections are submitted as follows:. 10A two lymph nodes 11. The specimen is labeled with the patient's name and "right neck level 3 & 4". It consists of portion of fibroadipose tissue measuring 4 x 4 x 1.2 cm. One piece of muscle measuring 3 x 3 x 1 cm is identified. One lymph node measuring 0.8 cm and one possible lymph node measuring 0.2 cm are identified. Representative sections are submitted as follows: 11A the lymph node bisected 118 the possible lymph node 12.The specimen container labeled with the patient's name and as "surgical waste", contains one triangle shaped piece of skin tissue measuring 3 x 3 x 1.8 cm. received in 10% buffered formalin. No abnormalities are noted grossly. No tissue is submitted, Page 3 of 4.
+
+--- Page 4 ---
+Surgical Pathology Consultation Report Quick Section Diagnosis 3. Negative for carcinoma. 4. High grade dysplasia; focally suspicious but not diagnostic of carcinoma 5. Negative for carcinoma 6. Negative for carcinoma 7. Negative for carcinoma. Addendum Addendum Diagnosis 1. Right marginal mandibulectomy. Bone negative for carcinoma. 2. Right anterior margin.. Bone negative for carcinoma.. Page 4 of 4
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diff --git a/output/text/b1568d33-ed97-475a-bb53-7eb5fc8af458.txt b/output/text/b1568d33-ed97-475a-bb53-7eb5fc8af458.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3cf2b7397d22c2b38dbe7da740900563bc4afc6c
--- /dev/null
+++ b/output/text/b1568d33-ed97-475a-bb53-7eb5fc8af458.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1Cb-0 -3 Carcmomu, N0s 8010/3 Sih:Buast L0 c50.s1f19/n fw P CQcF Sife: Buast,N0s c5o.9 Diagnosis: , Poorly differentiated invasive carcinoma (tumor diameter: 5.5 cm) Concluding tumor classification: NOS, G II, pT3N3aL0V0R0 JUID: 2728DB14-66D5-4E67-B9B6-63D93DBF509C Redacted A09G-01A-PR
\ No newline at end of file
diff --git a/output/text/b16067a8-b7f3-488d-bbef-122f5b6192a4.txt b/output/text/b16067a8-b7f3-488d-bbef-122f5b6192a4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d6f0f6e7ddcfc9423e636e3bc611bc6d137e2620
--- /dev/null
+++ b/output/text/b16067a8-b7f3-488d-bbef-122f5b6192a4.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+1cd-0-3 Path Siic Code : breest, nRpw ontor qusdrent C50.y 17fy1o jw eQcF Sitx: brst;ns c50.9 ynehrn.ons Senu hreaat : Final Diagnosis Breast, right,simple mastectomy: Multiple (2) nodules of invasive mammary carcinoma are identified. Infiltrating lobular carcinoma, Nottingham grade I (of II1) [tubules 3/3, nuclei 1/3, mitoses 1/3; Nottingham score 5/9] is identified forming a mass (1.1 x 0.9 x 0.8 cm) located in the upper outer quadrant of the breast [AJCC pT1c]. This cancer shows HER2/neu protein overexpression (scored as 2+; see comment below) and has metastasized to right axillary sentine! lymph node No. 1D as a roughly 1.1 mm keratin positive collection of tumor cells barely visible by routine H&E morphology (see comment regarding right axillary sentinel lymph node excision below). Infiltrating ductal carcinoma, Nottingham grade I (of IIl) (tubules /3, nuclei /3, mitoses /3; Nottingham score /9] is identified forming a second lesion (1.7 x 1.5 x 0.9 cm) in the upper outer quadrant located 0.6 cm inferior and medial to the first lobular carcinoma mass [AJCC pT1c]. This tumor also shows HER2/neu protein overexpression (scored as 2+; see comment below). However, there is no morphologic evidence of metastasis by this second lesion into any of the sentinel lymph nodes.. Extensive ductal carcinoma in situ, intermediate nuclear grade, is present within and outside the invasive component with a separate nodule in the central/deep breast, 1.2 x 1.2 x 0.6 cm, located 1.4 cm medial to the infiltrating ductal carcinoma. Angiolymphatic invasion is not seen. The non-neoplastic breast parenchyma shows proliferative fibrocystic changes. Biopsy site changes are present. The tumor does not involve the nipple, overlying skin, or underlying chest wall. All surgical resection margins, including the deep margin, are negative for tumor (minimum tumor free margin, 0.4 cm, anterior/superior margin).. Lymph nodes, right axillary sentinel, excision: A single (of 12) right axillary sentinel lymph node is positive for metastatic carcinoma [AJCC pN1 mi (sn)]. This positive sentinel node is designated No. 1D (tissue block A4) and is characterized by a roughly 1.1 mm collection of keratin positive tumor cels without much in the way of H&E morphologic correlation. As noted above, this microscopic focus of cancer has lobular features. The remaining 11 right axillary sentinel lymph nodes are negative for metastatic cancer (verified by keratin immunostaining). Blue dye is identified in right axillary sentinel lymph nodes No. 1A, No. 2A, No. 3A, No. 3B, and No. 4. Blue dye is not identified in right axillary sentinel lymph nodes No. 1B, No. 1C, No. 1D, No. 2B, No. 2C, No. 2D, or No. 3C. HER2/neu protein overexpression is weakly positive, score of 2+, according to the interpretation guidelines in the FDA-approved HercepTest. This degree of overexpression is seen in both tumor nodules (using tissue blocks B2 and B4). Fluorescence in situ hybridization (FISH) for HER2/neu amplification will be performed and reported in an addendum.. HER2 protein immunohistochemical (IHC) test results are only valid for non-decalcified paraffin embedded specimens fixed in neutral buffered formalin or Bouin's fixatives. Testing is performed using commercially available kit/reagents employing a polyclonal antibody and a polymer-based detection system. ADDENDA: UUID: 10C43124-3C21-443C-8268-23BF8A4D317E TCGA-AR-A1AM-01A-PR Redacted
+
+--- Page 2 ---
+No amplification for HER2/neu is demonstrated by fluorescence in situ hybridization (FISH, performed in Laboratory Genetics) (blocks B2 and B4) according to the interpretation guidelines in the FDA approved PathVysion Her2 DNA Probe Kit.
\ No newline at end of file
diff --git a/output/text/b185ea78-4851-4606-a6e2-c8a3d4e0207b.txt b/output/text/b185ea78-4851-4606-a6e2-c8a3d4e0207b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d0a36c355679dc0571353233a3d6da50a4a793c7
--- /dev/null
+++ b/output/text/b185ea78-4851-4606-a6e2-c8a3d4e0207b.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID: BCFE115C-4472-4221-86B3-75B122F9B425 TCGA-WC-A882-01A-PR Redacted Accession: IDt 3 Specimen Date/Time: 8772/3 DIAGNOSIS > 90 % (A) RIGHT GLOBE: 4 0dnejcC69.8  CILIOCHOROIDAL MELANOMA, SPINDLED TYPE, 12 MM BASE MINIMAL SCLERAL INVASION JS 1/16114 Vortex veins negative for tumor Optic nerve negative for tumor Extraocular extension is not identified.. See comment. COMMENT The tumor does not involve the canal of schlemm. Mitoses are low ( < 1 per 10 HPF). A PAS was reviewed and highlights ir structures. GROSS DESCRIPTION (A) RiGHT Gl.OBE - An intact right eye (23 mm anterior to posterior x 22 mm horizontally x 22 mm vertically), has an attac. optic nerve (6 mm in length). The cornea is clear (12 mm horizontally x 12 mm vertically). The anterior chamber is clear an. formed by a tan-gray iris with a round 6 mm in diameter pupil. Sclera is unremarkable. On transillumination, a shadow fron o'clock hours beginning at the limbus and extending to 12 mm from the optic nerve, corresponds to a tumor. The eye is op. vertically. The lens is transparent. The vitreous is clear. A tan-brown tumor, 12 x 10 mm base x 8 height, involves the cilia. body and the choroid. The sclera beneath the tumor is grossly intact.. Tissue is harvest per protocol.. SECTiON CODE: A1, superior temporal vortex vein; A2, superior nasal vortex vein; A3, inferior nasal vortex vein; . inferior temporal vortex vein; A5, pupil optic nerve section; A6, A7, nasal/temporal calotte; A8, optic nerve cross section, ma. face. CLINICAL HISTORY None given. SNOMED CODES T-AA000, M-2703 *Some tests reporled here may have bsen developed and performance characteristics determined by. These tes!s have no specifically cleared or approved by the U.S. Food and Orug Administration.". Entire report and diagnosis completed by:. -END OF REPORT- hw 1023[i
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diff --git a/output/text/b1875153-a74a-49b0-bccf-e227908587ef.txt b/output/text/b1875153-a74a-49b0-bccf-e227908587ef.txt
new file mode 100644
index 0000000000000000000000000000000000000000..14d644bd80191baee21a591a0370bffc440b78bf
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+TD e 3 UUID: E2B9489B-520E-4BBB-ADF1-4981E1C3374D TCGA-V4-A9EV-01A-PR Redacted Mlanm ypithuliciol +opndle 877/3 seiI misol Ste Chorsi( eiY.3 MueaI tsJ Cb9.41 Enucleation of the right eye JtJ31i11y Macroscopy The eyeball mesures 24X23 mm main lines with a segment of optic nerve of 2 mm At the section, a pigmented tumor measuring 18X15 mm is observed. Tissue specimens are taken for genetic studies, tumor xenografts and cryopreservation prior fixation. The specimen has been included entirely.. Su Rath diserpsucy f fom fr lpitelioi'd Microscopy The tumor observed macroscopically presents the histological aspect of an uveal melanoma. This tumor is composed mainly of fusiform cells (60%), rather small size with moderate atypias. Some large cells with strong cytonuclear atypias are also observed. Some tumor cells present melanin. The mitotic activity is inconspicuous. There is no necrosis. Topographically, the tumor is developed at distance of the ciliary body and of the optic nerve. The optic nerve is free of tumor on its entire course. There is no sclera tumor extension, and no tumor embolisms. Conclusion Uveal melanoma of the right eye. Fusiform cells predominant (60%). Epithelioid cells : 40% Tumor size: 18 mm main line. Mitotic activity: low. No scleral extension. Optic nerve on its entire course, optic nerve cut end and meningeal sheaths free of tumor. hv 13/3a/l3
+
+--- Page 2 ---
+TCGA Pathologic Diagnosis Discrepancy Form V4.00 Instructlons: The TCGA Pathologic Diagnosis Discrepancy Form should be completed when the pathologic diagnosis. documented on the initial pathology report for a case submitted for TcGA is inconsistent with the diagnosis provided on the Case Quality Control Form completed for the submitted case. Tissue Source Site (Tss): -.. TSS Identifier: . TSs Unique Patient Identifier: ... Completed By (Interviewer Name on OpenClinica): .... Completed Date:  Diagnosis Information Data Element Entry Alternatives Working Instructions 40% epithelioid cells Provide the diagnosis/histologic subtype(s) documented on Pathologic Diagnosis the initial pathology report for this case. If the histology for. Provided on Initial this case is mixed, provide all listed subtypes. 60% spindle cells Pathology Report Histologic features of 61-90% epithelioid cells Provide the histologic features selected on the TCGA Case  the sample provided Quality Control Form completed for this case.  for TCGA, as reflected 1-30% spindle cells  on the CQCF. Discrepancy between Pathology Report and Case Quality Control Form Provide the reason for  Provide a reason describing why the diagnosis on the initial. The section of the frozen sample used for sending  pathology report for this case is not consistent with the  the discrepancy  between the pathology to TCGA corresponds to a section of the tumor. diagnosis selected on the TCGA Case Quality Control Form.. where the epithelioid part is predominant.. report and the TCGA Case Quality Control Form. The percentages mentioned on the initial Pathology Report correspond to an average on the whole embedded sections used for establish the.. Pathology Report. Name of TsS Reviewing Provide the name of the pathologist who reviewed this case. Pathologist or for TCGA.  Biorepository Director I acknowledge that the above information provided by my institution Is true and correct and has been qualtty controlled.. TSS Reviewing Pathologist or Biorepository Director Date I acknowiedge that the above information provided by my institution is true and correct and has been quallty controlled. The Attending Pathologlst or ths Department Chatrman has been informed or is aware of the above discrepancy in diagnoses.. Principal Investigator Signature Date
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diff --git a/output/text/b195a703-8240-4731-8896-f3e3c5b19e58.txt b/output/text/b195a703-8240-4731-8896-f3e3c5b19e58.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e76cd92d915c7bec614a18035d285d91386e2cc5
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+lnfjirnotiny ouct, NUs 1*J 1w j1O Curcinomu,.. 8500]3 Site code :. Nos C 50.9 lw Wreast CHIEF COMPLAiNT/ PRE-OP/ POST-OP DIAGnOSIS: 1.2-cm mass postenor 12 o'clock right bresst. Core blopsy invasive ductale carcinoma. LMP DATE: Not provided.  PROcEDURE. Righl segmental mastectomy/sentinel tymph node biopsies SPECIFIC CLINICAL QUESTION: Not provided. UUID:771497E1-473E-421A-A149-CFA58E95B728 OUTSIDE TISSUE DIAGNOSIS: No. TcgA-Bh-A18F-01a-PR Redacted PRIOR MALIGNANCY. No. CHEMORADIATION THERAPY: Na. OTHER OISEASES No. ADDENDA: Addendum There a few satellite nodules ranging in size from 0.5-2 mm, which measure 0.5-1.2 cm from the main dominant noduie. These satelllte nodules are the nodules that are seen closest to the margins. as reported. FINAL DIAGNOSIS: Part 1: Breast,RIght/ segmental mastectomy - A. INYAsIYE DUCTAL CARcINOMA (sOe comment). 8. nOTTingham Grade 3 (tusuLe fOrmatiOn 3, nuclear Pleomorphism 3, mitOtic activity 3; TOTal SCORe 9/9). C. THe inVasIve tumOr MEASUreS 1.1 Cm in GREaTest DImenSiOn (ON SLIde IK). D.  NO DuCtAL CArcinomA In-SITU (DCIS) IS IDenTIFIeD. E.  NO LyMPHOVASCULAR SPACe INVASION IS IDENTIFIED. F.  RESECTiON MARGINS ARE NEGATIVE FOR INVASIVE CARCINOMA; INVASIVE CARCINOMA MEASURES  Less Than 1 mm from the AnteriOr and inferior margins, 1 mm From the medial mArgin, ANO 1.5 MM FROM THE POSTERIOR MARGIN. G. SKIN, NEGATIVE FOR TUMOR H.  ATYPICAL DUCTAL HYPERPLASIA. Calcifications associated with invasive carcinomA. J. FIBROCYSTIC CHANGES WITH DUCTAL EPITHELIAL HYPERPLASIA ANQ COLUMNAR CELL ALTERATIONS CHANGES CONSISTENT WITH PRIOR BIOPSY SITE The invasive tumOr CeLLs Are Negative fOr estrogen AnD Progesterone RecePtors AnD ALSO NEGATIVE FOR HER-2/NEU (SCORE O). AS PER PREVIOUS REPORT  Part 2: AxILLA, Right, Cyst excISIOn - EPIDERMAL INCLUSION CYST. Part 3: Lymph node, right axillary, sentinel. #1, Biopsy - ONE LYMPH NODE, NEGATIVE FOR METASTATIC CARCINOMA (O/1). PaRt 4: Lymph nODE, RIght AXILLARy, SENTINel #2, BIOPSy - ONE LYMPH NODE, NEGATIVE FOR METASTATIC CARCINOMA (O/1). Part 5: Lymph nOde, Right AxilLAry, Sentinel #3, BiOpsy - ONE LYMPH NODE, NEGATIVE FOR METASTATIC CARCINOMA (O/1) COMMENT: The triple negative invasive tumor was reported to be positive for basal markers, as per previous report (. Aithough the mass grossiy measured t.4 cm by gross examination, the tumor is best estimated to be 1.1 cm. based on the mlcroscopic measurement from slide 1K.. CASE SYNOPSIS: SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST LATErALITy: Right PROCEDURE: Segmenta!, LOCATION: Clock poslton:12 odock. SiZE OF TUMOR: Maxdmum dimension invasive component: 11 mm MULTICENTRICiTYAMULTIFOCALITY OF InVASIVE FOCI: No TUMOR TYPE (invasive component): Ductal adenocarcinoma, NOs, Other Type(s): Basal-like phenotype conhrmed by 1HC on biopsy NOTTINGHAM SCORE: Nuclear grade: 3 Tubule formation 3 Mitotic activity score. 3 Total Nottingham score: 9. Nottingham grade (1, 2. 3): 3 ANGIOLYMPHATIC INVASION: No DERMAL LYMpHATIc INVASION: No CALCIFICATION: Yes, malignant zones SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No Distance of invasive tumor to closest margin: 0.5 mm. Lymph nODes POsITive: 0 Lymph nodes examined: 3 mEtHOD(S) Of LYmPh NODE EXAmiNATION:  H/E stain SENTINEL NODE METASTASIS: No Skin inVOlVeo (uLCeRATION): No NON-NEOPLASTiC BREAST TiSsUE: ADH, FCD, Other: ductal epithelial hyperplasia, columnar cell alterations T stage, pathologic: pT1c N StagE, PAthOLOgIC: pNO M stage:  Not applicable EstROgen REcepTOrS: negative  PRogesterone receptOrs:  negative HER2/NEU:
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diff --git a/output/text/b19d0258-c3f7-4e1a-a6de-6024fca6c336.txt b/output/text/b19d0258-c3f7-4e1a-a6de-6024fca6c336.txt
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index 0000000000000000000000000000000000000000..9f157fd28a71ba1a0aa8fd9460ebd5df1ec63434
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+1cs-0-3 Careinome, Infi1tratiny duct, NoS 85ovf3 lw Sik: bunt,Nvs  UUID:0CF5DE3C-272C-4127-8047-435901278181 TCGA-D8-A13Y-01A-PR  Redacted c50.9 page 1 / 1 Department of Cancer Pathology copy No. Date: Examination: Histopathological examination Internal invoice No. Value of diagnostic procedure Examination No.: Patient: PEsEL: Age: Gender: F Material: Multiole orean resection -- rieht breast Unit in charge:  Physician in charge: Material collected on: Material received on. Expected time of examination: up to 8 working days Clinical diagnosis: Cancer of the right breast.  Examination performed on: Results of immunohistochemical examination: Estrogen receptors found in 10-75% of neoplastic cell nuclei. Progesterone receptors found in 10-75% of. neoplastic cell nuclei. HER2 protein stained with HercepTest'" by DAkO. Negative reaction in invasive. cancerous cells I Score = 1+ ) Compliance valldated by Examination performed on: Macroscopic description:. / Right breast, sized 16.6 x 12.4 x 4.8 cm, removed along with axillary tissues sized 8 x 6 x 2 cm and a skin flap of 10,7 x 8,4 cm. Weight 513 g. Tumour sized 1,5 x 1,9 x 1,0 cm in the upper outer quadrant, placed 3.3 cm from the upper edge, 0.1 cm  from the base and 0.8 cm from the skin. Microscopic description: /Carcinoma ductale invasivum - NHG3 (3 + 3 +3: 52 mitoses/ 10 HPF, visual area diameter: 0.55 m). Tumour of "basal - like carcinoma" morphology ? Ma mi 11 a sine laesionibus. Glandular tissue showing lesions of the type mastopathia fibrosa et cystica.. Additional parenchyma atrophy. AXILLARY LYMPH NODES  Lymphonodulitis chronica et sinus histiocytosis lymphonodorum (No VI). Examination result: Carcinoma ductale invasivum mammae dextrae. wCTAL 1NvA8iVE cAR5NIMA CF THE RisHT (NHG3, pTIc, pNO). Bremst. Tumour of "basal - like carcinoma" morphology. Compliance validated by:
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diff --git a/output/text/b1a6b93f-ebe9-43b0-bf83-067524ccbd75.txt b/output/text/b1a6b93f-ebe9-43b0-bf83-067524ccbd75.txt
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index 0000000000000000000000000000000000000000..e3bff0f4c1e136256c559783db38ecbd81be620e
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+UUID:B07B7F9E-9DC0-4FA2-88C3-6159A85206BB Department of Pathology -AAVK-01A-PR Redacted Tissue Source Site (TSS) #: Pathoigy Accession No: Patient ID: Normal Sample ID: Pathology Report DIAGNOSIS (A) RIGHT KIDNEY AND RIGHT ADRENAL: RENAL CELL CARCINOMA (7.5 CM IN LARGEST DIMENSION), PAPILLARY TYPE 2, FUHRMAN NUCLEAR GRADE 3, INVASIVE INTO RENAL SINUS ADIPOSE TISSUE No tumor invasion into renal vein or perinephric adipose tissue. METASTATIC RENAL CELL CARCINOMA INVOLVING ONE OF ONE HILAR LYMPH NODE (1/1) Margins of resection (ureteral, vascular, perinephric soft tissue), no tumor present. Adrenal gland, no tumor present. (B) PARACAVAL AND RETROCAVAL LYMPH NODE: METASTATIC RENAL CELL CARCINOMA INVOLVING FOUR OF SIX LYMPH NODES (4/6) GROSS DESCRIPTION (A) RIGHT KIDNEY AND RIGHT ADRENAL -- A radical nephrectomy specimen (20 x 15 x 5 cm) including the right kidney (12 x 7 x 5 cm), segment of the renal artery, renal vein, and ureter (8 cm in length and 0.8 cm in average diameter), and a separate. adrenal gland (7 x 2.5 x 1 cm). There is a 7.5 x 6.5 x 5 cm well-circumscribed tumor in the lower pole of the kidney. The tumor is brown-red with.  approximately 75% hemorrhage and necrosis, which are present predominantly in the center of the tumor. The tumor appears confined to the kidney. The tumor does, however, bulge into the renal sinus. The renal vein appears grossly uninvolved. The. tumor does not extend into Gerota's fascia.. The adjacent kidney parenchyma is unremarkable. The pelvicalyceal system is smooth and devoid of any lesions. A. single candidate lymph node (0.4 cm) is identified in the hilum of the kidney. Serial sections of the right adrenal gland show unremarkable cortex and medulla. Portions of tumor and normal kidney are submitted for research purposes. INK CODE:Black- Gerota's fascia. SECTION CODE: A1, ureter, renal artery and renal vein margins, en face; A2, A3, tumor adjacent to renal vein; A4, A5, tumor bulging into renal sinus; A6, tumor with possible involvement of vessel; A7, tumor in renal pelvis; A8, A9, tumor bulging into fat with overlying inked margin; A10, tumor with renal capsule; A11, tumor bulging into renal sinus; A12, tumor/normal kidney; A13, tumor with renal capsule; A14, normal kidney; A15, possible hilar lymph node; A16, right adrenal gland. (B) PARACAVAL AND RETROCAVAL LYMPH NODE - A 4.5 x 3.4 x 1.5 cm aggregate of fibroadipose tissue which yields multiple possible lymph nodes ranging from 0.5 to 2.5 cm in greatest dimension. The lymph nodes are submitted entirely.. SECTION CODE: B1, two lymph nodes; B2, three lymph nodes; B3, B4, one lymph node serially sectioned. Icd-0:3 CLINICAL HISTORY arenom, ysploy enal eeII 8Q6/3 None given. Site: Kuduy NBs 5 Q44.9 SNOMED CODES T-71000, M-Y7343, T-C4400, M-Y7346 QJ5/19|14 w n
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diff --git a/output/text/b1b97b0f-a3f8-41b0-8001-ad121bbe6c55.txt b/output/text/b1b97b0f-a3f8-41b0-8001-ad121bbe6c55.txt
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index 0000000000000000000000000000000000000000..e41a30a2034b25313f5993facfeb05fe5ae35189
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+with large right renal mass. Specimens Submltted:. 1: SP: Tumor, right kidney for diagnosis 2: SP: Right kidney cyst wall. DIAGNOSIS:E 1) KIDNEY, RIGHT; PARTIAL NEPHRECTOMY: - RENAL CELL CARCINOMA, CLEAR CELL (CONVENTIONAL) TYPE, NUCLEAR GRADE II/IV. - THE PATTERN OF GROWTH IS SOLID. - THE TUMOR GREATEST DIAMETER IS 2.2 CM. - THE TUMOR IS CONFINED WITHIN THE RENAL CAPSULE. - NO INVASION OF THE RENAL VEIN IS IDENTIFIED. - THE SURGICAL MARGIN IS FREE OF TUMOR - THE NON-NEOPLASTIC KIDNEY IS UNREMARKABLE. 2) CYST WALL, RIGHT KIDNEY; EXCISION: - BENIGN RENAL PARENCHYMA WITH BENIGN CYST. Special Studies:. Special Stain Rasult Commente RECUT 1) Tha specimen is recelved fresh for frozon sectlon, labaled "Tumor, right kidney for diagnosis. Stltch marks deep margin'.. It conslsts of a partial nephrectomy with attachad parinephric fat, measuring 15 x 8 x 4 cm overall, with a 5.0 x 4.5 x 3.0 cm portion of kidnay. The deep margin is inked black. Tha specimen is sectloned to ravaal a 2.2 x 1.9 x 1.2 cm circumscribed, tan-yellow. mass with foci of hamorrhage. It Is grossly 0.4 cm from the inked stitchad margin of resectlon. The mass is grossly confinod to the kidnay and doos not oxtend into tho porinaphric fat. A portion is submltted for A portion is fixed in EM fixative for possible futuro studias if nacassary. Summary of Sections: FSC - Frozen sectlon contro!. M - Mass Page 1 of 2
+
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+NK - Normal kidney. 2) The specimen is received in formalin, labeled "Right kidney, cyst wall.It consists of a 0.8 x 0.4 x 0.2 cm tan-whlte soft tlssue fragment which is entirely submitied. Summary of Sections:. CW - Cyst wall Summary of Sections: Part 1: SP: Tumor, right kidney for dlagnosis (1 Block Sect. Site pCs 1 f$c 1 5 m 5 1 nk 1 Part 2:$P: Right kidney cyst wall Block Sect. Site PCs 1 CW 1 Intraoperative Consultatiou: Note: The diagnoses given In this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS: RENAL CORTICAL NEOPLASM. MARGIN FREE OF TUMOR.  PERMANENT DIAGNOSIS: SAME Page 2 of 2 END OF REPORT
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diff --git a/output/text/b1e67a8e-ff42-4100-a181-6d72f51f4e0d.txt b/output/text/b1e67a8e-ff42-4100-a181-6d72f51f4e0d.txt
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index 0000000000000000000000000000000000000000..d2afe70a287c6db1d81ec2e2c8dd972e957f8a1f
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+TSS ID /cs-0-3 SPECIMENS: A. WLE RIGHT BREAST NEEDLE LOCALIZATION Carcinona, mifiAtrating ductl, nos 85o0/3 B. SENTINEL NODE #1 Sifu: breaot, Nos C50.9 C. SENTINEL NODE #2 F/8/r D. ADDITIONAL LATERAL POSTERIOR MARGIN SPECIMEN(S):  UUID:CC0B1145-B242-458D-A946-B14BA5A9E9230 A. WLE RIGHT BREAST NEEDLE LOCALIZATION TCGA-E2-A1IN-01A-PR Redactedd B. SENTINEL NODE #1 C. SENTINEL NODE #2 D. ADDITIONAL LATERAL POSTERIOR MARGIN INTRAOPERATIVE CONSULTATION DIAGNOSIS: A-WLE right breast: Gross examination only, tumor is 0.8 cm from the nearest superior margin. TPB/TPC-SLN #1, #2: Touch imprints only, negative for tumor cells. Diagnoses called by Dr. to Dr. at . (A, B, C). GROSS DESCRIPTION: A. WLE RIGHT BREAST NEEDLE LOCALIZATION Received fresh labeled with the patient's identification and *wLE right breast needle localization" is a previously inked, oriented (single suture-anterior, double suture-lateral) 76 g, 3.7 x 3.6 x 2.9 cm needle localized lumpectomy with radiograph. Ink code: Anterior-yellow, posterior-black, medial-green, lateral- red, inferior-blue, inferior-orange. The specimen is serially sectioned from lateral to medial into 7 slices. revealing a 1.8 x 1.3 x 1.1 cm tan, stellate nodule that is closest to the superior margin at 0.8 cm.. Tissue is procured. Representatively submitted: A1-A2: lateral margin, perpendicular sections A3: slice 2, anterior superior A4: slice 2, posterior superior A5: slice 2, posterior superior A6: slice 2, mid posterior A7: slice 3, anterior superior (mass) A8: slice 3, posterior superior (mass). A9: slice 3, mid anterior (mass) A10: slice 3, mid posterior (mass). A11: slice 3, inferior A12: slice 4, mid anterior (mass). A13: slice 4, mid posterior (mass) A14: slice 4, mid inferior A15: slice 4, posterior A16: slice 5, anterior A17: slice 5, inferior A18: slice 5, posterior A19: slice 6, superior A20-A21: slice 6, anterior A22: slice 6, inferior A23: slice 6, posterior A25-A25: medial margin, perpendicular sections B. SENTINEL LYMPH NODE #1 RIGHT AXILLA Received fresh labeled with the patient's identification and *SLN #1" is a 1.5 x 0.7 x 0.4 cm lymph node. It is sectioned, a touch prep is performed, lymph node is submitted entirely in cassette B1. C. SENTINEL LYMPH NODE #2 RIGHT AXILLA Received fresh labeled with the patient's identification and *SLN #2" it is a 1.7 x 0.3 x 0.1 cm lymph node. It is sectioned, a touch prep is performed, submitted entirely in cassette C1. D. ADDITIONAL LATERAL POSTERIOR MARGIN Received fresh labeled with the patient's identification and "additional lateral-posterior margin" is an oriented (suture at final margin) 9 g, 5 x 3 x 1.2 cm fibrofatty tissue. Final margin is inked blue. Serial sectioning reveals no discrete lesions. Entirely submitted in cassettes B1-B8. DIAGNOSIS:E A. BREAST, RIGHT, WIDE LOCAL EXCISION: - INVASIVE DUCTAL CARCINOMA, SBR GRADE 3, MEASURING 1.8-CM 1
+
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+TSS ID - HIGH NUCLEAR GRADE, DUCTAL CARCINOMA IN SITU, SOLID AND CRIBRIFORM TYPES WITH MICROCALCIFICATIONS - 1NVASIVE TUMOR PRESENT WITHIN 1-MM FROM INFERIOR SURGICAL RESECTION MARGIN - LOBULAR CARCINOMA IN SITU - SEE SYNOPTIC REPORT. B. LYMPH NODE, SENTINEL #1, RIGHT AXILLA, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (O/1). C. LYMPH NODE, SENTINEL #2, RIGHT AXILLA, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (O/1). D. BREAST, ADDITIONAL LATERAL POSTERIOR MARGIN, EXCISION: - BREAST TISSUE, NO TUMOR SEEN. SYNOPTIC REPORT - BREAST Specimen Type: Excision Needle Localization: Yes - For mass  Right Present Invasive Tumor: Multifocality: No WHO CLASSIFICATION Invasive ductal carcinoma, NOs 8500/3 Tumor size: 1.8cm Margins: Negative Distance from closest margin: Less than 0.1cm inferior Tubular Score: 3 Nuclear Grade: 2 Mitotic Score: 3 3 Modified Scarff Bloom Richardson Grade: Necrosis: Absent  None identified Vascular/Lymphatic Invasion: Lobular neoplasia: LCIS Lymph nodes: Sentinel lymph node only. Lymph node status: Negative 0/2 DCIS present Margins uninvolved by DCIS DCIS Quantity: Estimate 10% DCIS Type: Solid Cribriform DCIS Location: Associated with invasive tumor Nuclear grade: High Necrosis: Absent DCIS Location of CA++: Benign epithelium ER/PR/HER2 Results ER: Positive PR: Positive HER2: Negative by IHC Performed on Case: Pathological staging (pTN): pT 1c N O Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition Distant Metastases (M): MX: Cannot be assessed CLINICAL HISTORy:  None given
+
+--- Page 3 ---
+TSS ID PRE-OPERATIVE DIAGNOSIS:  None given ADDENDUM: ONCOTYPE DX BREAST CANCER ASSAY RESULTS: Recurrence Score: 14 CLINICAL EXPERIENCE: Patients with a recurrence score of: 14 in the clinical validation study  had an average rate of Distant Recurrence at 10 years of 9% Er Score: 11.3Positive PR Score: 9.1 Positive Her2 Score: 9.1 Negative Interpretation: ER  Negative < 6.5 Positive >= 6.5 PR  Negative < 5.5 Positive >= 5.5 Her2 Negative <10.7  Positive >=11.5 Equivocal = 10.7 - 11.4 Microscopic/Diagnostic Dictation:, . Final Review:, M.D., Pathologist. Final: M.D., Pathologist, 1 Addendum: M.D., Pathologist, ( Addendum Final: M.D., Pathologist,
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diff --git a/output/text/b1f71a3e-4096-451a-a34c-977f3133efd8.txt b/output/text/b1f71a3e-4096-451a-a34c-977f3133efd8.txt
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index 0000000000000000000000000000000000000000..8d7dad581b05002ea5be63b1fcd761dac17ada7a
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+FiNAL DIAGNOSIS: Part 1: Lymph node, right axillary, sentinel. node number 1, sentinel node biopsy -. ONE LymPh nODE POSITiVE fOR mETASTaTIC CARcinOmA (1/1). Part 2: Lymph nODe, RIght AXIlLARy, SentiNeL nODe NumBer 2, Sentinel nOde BiOpSy - One Lymph nOde pOsitIve fOR metastatic CARcinomA (1/1). Part 3: Lymph node, right axillary, nonsentinel, Lymph node biopsy -- TWO Lymph NODes nEgAtive fOR metAStATiC CArcinOma (0/2). Part 4: Lymph node, right axillary, Sentinel node number 3, sentinel node biopsy - 1cs-0-3  One Lymph nODe pOsitive for micrOmetastatic CArcinoma (1/1). Chrtnoma infi/trstg cluct,n0s 8560/3 Part 5: breast. Right, Segmental mastectomy - Sits:buest,Nos C5O.9 3f13/u p A.  Infiltrating Ductal Carcinqma. B. nOtTinghAm'ScORe 4/9, grAbe 1 (tuBuLes 2, nucleI 1, mitOses 1). C.  NEOPLASM mEASURES 2.8 CM iN mAXImUm DimENSION (see comment). D.  NO LYMPHOVASCULAR INVASION IDENTIFIED. E.  NEOPLASM EXTENDS FOCALLY TO POSTERIOR MARGIN OF RESECTION IN THE INFERIOR ASPECT (BLOCK 5J), ALL Other mArgins Of ReSectiOn free Of neOpLASm. F Er positive, pr negative, her-2/neu negative per previous report. G. Pathologic Stage: pt2, pN1, pMX. H. DUCTAL CARCINOMA IN SITU, CRIBRIFORm AND MICROPAPILLARy TYPES, NUCLEAR GRADE 1 WITH ASSOCIATED MICROCALCIFICATIONS AND FOCAL COMEDONECROSIS. I. in SiTU COMpONeNt IS ADMIXED WITh INVASIVE COMpONenT AND IS IDEnTIFIeD iN EIght BLOCKS (THrEE COnSEcuTIVE SLiCEs mEASURING APPROxImATeLy 1.2 Cm). J. MArGiNs Of RESEctiOn frEe Of in Situ COmpOnent, CLOseSt iNferiOR at 0.3 Cm. K. Atypical Ductal hyperplaSiA. FAT NECROSIS AND REPARATIVE CHANGES ASSOCIATED WITH PREVIOUS BIOPSY. M. FIBrROCySTIc CHAnges WITh SCLerOsing ADenOSIS, DUctAL EPitheLiAL hypERPLASIA, FIBROADENOMATOUS NODULE AND EPITHELIUM ASSOCIATED CALCIFICATIONS. Part 6: Lymph nodes, Right AxilLary, AxilLary Dissection -  Nineteen Lymph noDes negative for metastatIc Carcinoma (0/19). CASE SYNOPSIS:  SynOpTiC - PRImARy INVASIVE CARCinOmA Of bREASt LAtEraLITy: PRoceDUre: Right LOCATION: Segmental Not specified SIZE OF TUMOR:  Maximum dimension invasive component: 2.8 cm  MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: TUMOR TYPE (invasive component): No NOTTINGHAM SCORE: Ductal adenocarcinoma, NOS Nuclear grade: 1 Tubule formation: 2 UUID:7F75F15A-2476-4FFD-97B3-313F06568E21 Mitotic activity score: 1 TCGA-BH-A0BM-01A-PR Redacted Total Nottingham score: 4 Nottingham grade (1, 2, 3): 1 ANGIOLYMPHATIC INVASION: No DERmAL LyMPHATIC INVASION: CALCIFICATION: Not applicable Yes, benign zones Yes, malignant zones TumOr TYpe, iN SITu: Cribriform Micropapillary DCIS admixed with invasive carcinoma  Percent of tumor occupied by in situ component: 5 % SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: SURG MARGINS INVOLVED BY IN SITU COMPONENT: Yes, focal No Distance of in situ disease to closest margin: 3 mm LymPH nODES POSITiVE: LYMPH NODES EXAMINED: 3  METHOD(S) OF LYMPH NODE EXAMiNATION: 24 H/E stain, Keratin stain SENTINEL NODE METASTASIS: Yes ONLy KERATIN POSITIVE CELLS ARE PRESEnT: SIZE OF NODAL METASTASES: No Diameter of largest lymph node metastasis: 25.0 mm LYMPH NODE METASTASIS(-ES) WITH EXTRACAPSULAR EXTENSION: NON-NEOPLASTIC BREAST TISSUE: ADH, FCD No t stage, pathologic: pT2 N stage, pathologic: m stage, pathologic: pN1a ESTROGEN RECEPTORS: pMX  positive PROGESTERONE RECEPTORS: negative HER2/NEU: zero or 1+
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diff --git a/output/text/b21a9006-d0f1-49c9-a7d9-3ba694e3be6c.txt b/output/text/b21a9006-d0f1-49c9-a7d9-3ba694e3be6c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1c49c7693c0b52e80ccfed0ec78a96e065d41679
--- /dev/null
+++ b/output/text/b21a9006-d0f1-49c9-a7d9-3ba694e3be6c.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+1cd-0-3 Carcinomn, infuttreting duct,NOS 85oo[3 J2/8|10 Pash Sini hrsst, nos CQcF C50.9 TSS: UUID:3528F6A2-974B-440E-B80B-DCD79874DAC3 SPECIMENS: TCGA-E2-A15-01A-PR A. SENTINEL LYMPH NODE #1 LEFT AXILLAS Redacted B. SENTINEL LYMPH NODE #2 LEFT AXILLAE C. SENTINEL LYMPH NODE #3 LEFT AXILLA D. SENTINEL LYMPH NODE #4 LEFT AXILLA E. LEFT BREAST SPECIMEN(S): A. SENTiNEL LYMPH NODE #1 LEFT AXILLA B. SENTINEL LYMPH NODE #2 LEFT AXILLA C. SENTINEL LYMPH NODE #3 LEFT AXILLA D. SENTINEL LYMPH NODE #4 LEFT AXILLA E. LEFT BREAST INTRAOPERATIVE CONSULTATION DIAGNOSIS: TPA/TPB/TPC/TPD1/TPD2/TPD3/TPD4-SLN #1, #2, #3, #4: No tumor seen. Diagnoses called a Dr to Dr. at. A, B, C, D) GROSS DESCRIPTION: A. SENTINEL LYMPH NODE #1 LEFT AXILLA Received fresh labeled with the patient's identification and "SLN #1" is a 1.1 x 0.7 x 0.5-cm lymph node; sectioned, a touch prep is performed, and lymph node is submitted entirely in cassette A1. B. SENTINEL LYMPH NODE #2 LEFT AXILLA Received fresh labeled with the patient's identification and "SLN #2" is a 0.8 x 0.6 x 0.4 cm lymph node; sectioned, touch prep is performed, submitted entirely in cassette B1.. C. SENTINEL LYMPH NODE #3 LEFT AXILLA Received fresh labeled with the patient's identification and "SLN #3" is a 1 x 0.8 x 0.6 cm lymph node; sectioned, a touch prep is performed, and lymph node is submitted entirely in cassette C1.. D. SENTINEL LYMPH NODE #4 LEFT AXILLA Received fresh labeled with the patient's identification and "SLN #4" are 4 lymph nodes, 0.4 x 0.4 x 0 .2 cm, 0.3 x 0.3 x 0.2 cm, 0.3 x 0.2 x 0 .2 cm, and 0.3 x 0.2 x 0.2 cm; 4 touch preps are performed, and lymph nodes are submitted respectively and entirely in cassettes D1-D4.. E. LEFT BREAST Received fresh labeled with the patient's identification and "left breast" is an oriented 574 g, 24 x 19 x 4.5 cm mastectomy with 10.5 x 4 cm skin ellipse and 1.3-cm everted nipple. Ink code: Anterior/superior-blue,.  anterior/inferior-orange, and posterior-black. Specimen is serially sectioned from lateral to medial into 10 slices with nipple in slice 7 revealing: 1) 3.5 x 3.4 x 2.2 cm area of hemorrhage and containing a biopsy site in the lower outer quadrant to the lower mid. section in slices 4-6 at is closest to the anterior margin at 2.3 cm  2) 5.5 cm superior to the biopsy site, in slice 6, is a 1.5 x 1.4 x 1.4 cm irregularly shaped firm tan mass in the upper inner quadrant that is closest to the anterior margin at 0.2 cm Within the axillary region is a 1 cm firm tan lymph node. Representatively submitted:. E1: slice 4, LOQ granular region lateral to biopsy site. E2: slice 5, most lateral aspect of area of hemorrhage and biopsy site. E3: slice 6, most inferior aspect of biopsy site extending to the anterior margin/skin. E4: slice 6, most inferior aspect of biopsy site extending to the posterior margin E5: slice 6, mid anterior region of biopsy site E6: slice 6, mid posterior region of biopsy site E7-E8: slice 6, fibrous tissue connecting biopsy site of lesion E9-E11: slice 6, upper inner quadrant mass including posterior margin (trisected) E12: slice 7, fibrous tissue medial to biopsy site E13: slice 7, fibrous tissue medial to mass E14: slice 10, LIQ E15: slice 9, UIQ E16: slice 3, UOQ E17: slice 2, LOQ E18-E19: nipple, perpendicular sections E20: skin and bisected lymph node. DIAGNOSIS: A. LYMPH NODE, SENTINEL #1, LEFT AXILLA, EXCISION - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1)
+
+--- Page 2 ---
+B. LYMPH NODE, SENTINEL #2, LEFT AXILLA, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1). C. LYMPH NODE, SENTINEL #3, LEFT AXILLA, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1). D. LYMPH NODE, SENTINEL #4, LEFT AXILLA, EXCISION: - FOUR LYMPH NODES, NEGATIVE FOR METASTASES (0/4) E. BREAST, LEFT, MASTECTOMY: - INVASIVE DUCTAL CARCINOMA, SBR GRADE 1, MEASURING 1.7-CM - INTERMEDIATE NUCLEAR GRADE, DUCTAL CARCINOMA IN SITU, SOLID, CRIBRIFORM, MICROPAPILLARY AND PAPILLARY TYPES WITH CENTRAL NECROSIS, MICROCALCIFICATIONS AND LOBULAR EXTENSION - SURGICAL RESECTION MARGINS NEGATIVE FOR TUMOR - FIVE LYMPH NODES, NEGATIVE FOR METASTASES (0/5) - LOW GRADE AND HIGH GRADE (PLEOMORPHIC) LOBULAR CARCINOMA IN SITU - TWO BIOPSY SITES WITH FIBROSIS ABD GRANULATION TISSUE  - SEE SYNOPTIC REPORT AND SEE NOTE. NOTE: Two lesions are grossly identified, both located in slice #6 (outer quadrants/central). The upper lesion is DCIS extending from slice #4 to slice #6, measuring approximately 3-cm. The second lesion is located centrally showing invasive ductal carcinoma, measuring 1.7-cm. The tissue sections between two lesions (slides #7 and #8)  show no invasive or in situ ductal carcinoma. SYNOPTIC REPORT - BREAST Specimen Type: Mastectomy  Needle Localization: No Laterality: Left Invasive Tumor:  Present Multifocality: No WHO CLASSIFICATION  Invasive ductal carcinoma, NOS 8500/3 Tumor size: 1.7cm Tumor Site: Upper outer quadrant Central Margins:  Negative Tubular Score: 2 Nuclear Grade: 2 Mitotic Score: 1 Modified Scarff Bloom Richardson Grade: Necrosis: Absent Vascular/Lymphatic Invasion:. None identified Lobular neoplasia: LCIS Lymph nodes: Sentinel lymph node only Lymph node status: Negative 0/12 DCIS present  Margins uninvolved by DCIS DCIS Quantity: Estimate 60% DCIS Type: Solid Cribriform Micropapillary Papillary DCIs Location:Both associated and separate from invasive tumor mass Nuclear grade: Intermediate Necrosis: Present Location of CA++: DCIS ER/PR/HER2 Results ER: Positive PR: Positive  HER2: Negative by FISH Performed on Case: Pathological staging (pTN): pT 1c N 0
+
+--- Page 3 ---
+CLINICAL HISTORY: Left breast invasive cancer with extensive surrounding DCIS PRE-OPERATIVE DIAGNOSIS: Left breast cancer ADDENDUM: ONCOTYPE DX BREAST CANCER ASSAY RESULTS: Recurrence Score: 20 CLINICAL EXPERIENCE: Patients with a recurrence score of:  20 in the clinical validation study had an average. rate of Distant Recurrence at 10 years of 13%. ER Score: 8.9 Positive PR Score: 7.6Positive Her2 Score: 9.9 Negative Interpretation: ER Negative < 6.5 Positive >= 6.5 PR Negative < 5.5 Positive >= 5.5 Her2 Negative <10.7 Positive >=11.5 Equivocal = 10.7 - 11.4 See separate ( report for further information. Test performed at: Microscopic/Diagnostic Dictation: Pathologist, Final Review: Patholoaist. Final: Pathologist, Addendum: Pathologist, Addendum Final: Pathologist, L
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diff --git a/output/text/b23495ab-8e61-45f1-b7a2-71ee73e3be01.txt b/output/text/b23495ab-8e61-45f1-b7a2-71ee73e3be01.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4a8f7c615e3668afe52e1e0efc11ddead95aef2a
--- /dev/null
+++ b/output/text/b23495ab-8e61-45f1-b7a2-71ee73e3be01.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis: Left hemicolectomy preparation with a moderately differentiated, invasive adenocarcinoma with infiltration of the pericolic fatty tissue. There is a further tubulovillous adenoma with focal, severe dysplasia (synonym: severe intraepithelial neoplasia). The tumor classification of the adenocarcinoma is: G2, pT3 N0 (0/27) L0 V0 R0.
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diff --git a/output/text/b241dc07-7d71-42c9-805a-7849223a82c7.txt b/output/text/b241dc07-7d71-42c9-805a-7849223a82c7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e7a95ae71aa1a7b56baae6053caac0070ba5eff7
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:C1ABCD83-40EA-4FF7-BE36-69679589E8E7 TCGA-AC-A2FG-01A-PR Redacted Collectedt Accesslon #: Recelved: Acct / Reg #: Reported: SURGICAL PATHOLOGY REPORT DIAGNOSIS DIAGNOSIS: A. Lent breast anxtaxillary contents, radical mastectomy: Tumor Characterlstics: Histotogic typet InvasNs lobular carcinoma.*? 2. Size: 2.1 cm inear messurement as measured on sllde A3. 3. Elston modification of Bloom-Rlchardson grade: a.Architectural Score:3/3. b. Nuclear Score: 3/3. C.Mitotic Score: 1/3. d.Total score: 7/9 = Grade: 2. 1CS-0-3 4 Lymphovascular space invasion: No. 5 Skin Involvement: No. Are microcalcifications identified In assoclation with tumor: No. c50.9 Sit: breast Nos 7 In situ component: Absent Surgical Margin Status: 1. Is tumor transected: No. 2. Tumor distance to closest margin: 0.7 cm from deep margin Lymph Node Status: 1. Total number of lymph nodes examined within spedmen A: Ten. 2. Total number of lymph nodes contalning metastatic carcinoma by gross exam or light microscopy: One. 3. Size of largest metastasis: 0.25 cm. 4 Extra-capsular extension of tumor: Yes. Other: Other slgnificant findings: Focus of fibrosls and hemorrhage compatible with prior biopsy site; mild fibrocystic change featuring apocrine metaplasia; focal florld ductal hyperplasla. B. Lymph node, left axillary, excision: Isolated single cell micrometastases identified with immunohistochemistry (pancytokeratin), not Identified on H&E. Electronic Slgnature: -*- COMMENTS: Thls case has been reviewed by  Breast cardnoma prognostic Indicator analysis was performed on the blopsy specimen A repeat of this analysis on the present specimen will not be obtalned unless requested by the primary ctinician. No definite tumor is Identifted with the H&E stalned sllde of the permanent control of the frozen sectlon materia) (Specimen B - Left axillary node). pTNM: T2N1MX. CL.INICAL INFORMATION
+
+--- Page 2 ---
+CLINICAL. INFORMATION CLINICAL HISTORY: Preoperative Diagnosis: Postoperative Dlagnosis:e Symptoms/Radiologlc Findings: SPECIMENS:D A. Left breast and axillary contents B.Axillary node (left) SPECIMEN DAIA GrOSS DescrIpTIOn: A labeled left breast and axillary contents Is a 581 gram left modified radical mastectomy specimen, 23.8 x 11.5 x 3.5 cm. The specimen is  partially covered by a 21.1 x 9.9 cm ellpse of tan skin. Eccentrically located is a non-retracted nipple surrounded by areola complex, 2.8 cm in diameter. The specimen Is Inked and sectoned to display a clrcumscribed tan white fibrous appearing nodule, 2.9 x 2.8 x 2.7 cm. The lesion is 0.7 cm from the  deep inked margin.. The remainder of the cut surface displays at least 50% interspersed blue-pink fibrous tissue. Additlonal lesions are nordentifled. The axillary contents measure 8.2 x 5.5 x 1.7 cm. On sectoning and palpaton, nine lymph nodes are kdenuned ranging from 0.3 to 1.4 cm in greatest. dimenslon.d Representative sections are submitted as follows: 1--nipple; 2-leslon to inked margin; 3 and 4--additlonal sectlons of leslon; 5--uninvoived tissue lower outer quadrant; 6--upper outer quadrant; 7--upper inner quadrant; &--ower inner quadrant; 9 and 10--individual nodes In each cassette; 11--one node blsected; 12--two whole nodes. Two cassettes for research ' Habeled axillary node !eft is a prevlously bisected tan yellow lymph node received for frozen, 1.5 x 0.6 x 0.4 cm, entirely resubmitted in one cassette l MB/map INTRA-OPERATIVE CONSULTATION: FSB: 'No definite tumor Identified per  MICROSCOPIC EXAMINATION: Microscopic examination performed.
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diff --git a/output/text/b27a443a-1545-4c5b-aa38-8b13b0597dce.txt b/output/text/b27a443a-1545-4c5b-aa38-8b13b0597dce.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6066900dac9488eb35c5e330e7612bec738a1f1d
--- /dev/null
+++ b/output/text/b27a443a-1545-4c5b-aa38-8b13b0597dce.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1c0-0-3 Carciioma, mfittrating Procedure Date: Primary Tumor Site Dirapany Auctol. Nos 8500/3 A Discreparicy Procedure Physician: S,fe. Bsst, nos c50,9 Attending Physician/Copies To: y/3ofu fw UUID:FA86A743-EA67-4554-ABA2-B88C1DBDB0B1 Patient history: TCGA-BH-A1EX-01A-PR Redacted SPECIMENS TAKEN BY PATH DATE Of LMP: (NOT LISTED ON REQUISITION) DATE OF LAST DELIVERY: PRE-OP DIAGNOSIS: RIGHT BREAST CANCER POST-OR DIAGNOSIS: SAME OPERATIVE PROCEDURB: R SENTINEL LYMPH NODE, R SEGMENTAL MASTECTOMY CLINICAL HISTORY: SPECIMENS TAKEN BY PATH MATERIAL SUBMITTED: A) RIGHT SENTINEL LYMPH NODE, PROCUREMENT BY SURGICAL PROCEDURE B) RIGHT BREAST BICPSY/TISSUE, PROCUREMENT BY SURGICAL PROCEDURE long-lat,med-med, sht-superior INTRAOPERATIVE CONSULTATION:R SENTINEL LYMPH NODE #1: One lymph node, 0.9 by 0.6 by 0.5 cm. Touch Prep Diagnosis: Negative. ADDENDA: Addendum FISH anaiysis using DNA probe for Her-2/neu gene showed that, the ratio of Her-2/neu signals to chromosome 17. centromere signals is 0.94 ( 2.0 ratio is considered amplified). Therefore, Her-2/neu gene is not amplifiod. Pathologst.  Report Electrotisl? ...Bv Patholo. My signature is attestation that I have personally reviowod the submitted material(s) and the above diagnosis retlects that evaluation. Addendum MATERIAL SUBMITTED: BLOCK "B3" FOR ER/PR AND HER-2/NEU (BREAST CANCER) FINAL DIAGNOSIS: ESTROGEN/PROGESTERONE RECEPTORS AND HER-2/NEU PERFORED ON RIGHT BREAST TISSUE tSTROCEN RECEPTOR (0- 40%; 1+ 40%; 2+ 10t; 3+ 10t) HSCORE OF 90. ESTROGEN RECEPTOR IS INTERPRETED AS POSITIVE PROGESTERONE RECEPTOR (0- 7Ot; 1+ 10t; 2+ 10t; 3+ 10t) HSCORE OP 60. PROGESTERONE RECEPTOR IS INTERPRETED AS POSITIVE HER-2/NEU-DAKO HERCEPTEST. A WEAK TO MODERATE COMPLETE MEMBRANE STAINING IS OBSERVED IN MORE THAN 1O4 OF THE TUMOR CELLS. HER-Z/NEU I8 INTERPRETED AS _POSITIVE (SCORE 2+) HSCORE: <- 15 NEGATIVE >15<=30 BORDERLINE FINAL DIAGNOSIS: FINAL DIAGNOSIS: A) RICHT SENTINEL LYMPH NODE #1:  MICROMETASTATIC DUCTAL CARCINOMA OF THE BREAST (SEE NOTE) B) RIGHT SEGSNTAL MASTECTOMY: MITOSIS-1) TUMOR MA99 9#12 LATERAL AND INFERIOR SURGICAL MARGINS POSITIVE FOR INVASIVE TUMOR INTRADUCTAL PAPILLOMA AND PROLIFERATIVE FIBROCYSTIC CHANGES IN THE REMAINING BREAST TISSUE - FOCAL NECROSIS AND GRANULATION TISSUE, STATUS-POST CORE BIOPSY OT SREAST (CROSS REFER NOre: Minute clusters of metastatic ductal carcinoma was found in serial section "ai", but it ie best. viaualized with the immunoporoxidase stain Anl/az3 in serial section A2. Tho immunostain was repeated and. the presence of motastatic neoplastic cella in the lymph node section "al" Hts was confirmed by immunostaining ("A2sa3"). Tho iater serial sections or the lymph nodes are negative. The touch prap of the. sentinel node was re- reviewed and no malignant cells are identified. ER/pR immunoperoxidase assay and Her- 2/Nsu testing will be performed on block "g3". The special stains and/or immunoperoxidase tests used in thi- -ase d and their performance Characterietics determined by the Department of Pathology at They have not been cleared or approved by the U.s. Fooa and Drug Administration.
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diff --git a/output/text/b2926547-f514-441d-8729-4e76c9ced1b1.txt b/output/text/b2926547-f514-441d-8729-4e76c9ced1b1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..012350bff02851f852d8b867fa89cb159b8c5b2a
--- /dev/null
+++ b/output/text/b2926547-f514-441d-8729-4e76c9ced1b1.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+IcD-o-3 cenemo rguamsuo mmetsplsotie 8s 7s/3 pot B %Ereoat unDal C 50.9 UUID:511282C5-02AC-4105-8B52-SBBEC8B45D22 TCGA-AR-A5QQ-01A-PR Redacted fsuin Cso.1 nJ 41z|13 A. Breast, right, simple mastectomy: Moderately differentiated squamous carcinoma. (metaplastic carcinoma) involving the mammary parenchyma forming a 5.2 x 5.0 x 4.7 cm mass Iocated in the central aspect of the breast with skin ulceration. Angiolymphatic invasion is present. The surrounding breast parenchyma shows nonproliferative fibrocystic changes. A single (of 3) intramammary lymph node is positive for metastatic carcinoma forming a solid and cystic mass (6.5 x 5.0 x 4.7 cm) located in the lateral aspect of the breast. Extranodal extension is present. The skin and nipple areolar region is involved by tumor. All surgical resection margins, including skin and deep margins, are negative for tumor (minimum tumor free margin, 1.7 cm, deep margin). Estrogen receptor, progesterone receptor, and HER2 will be performed and reported in an. addendum. B. Lymph nodes, right axillary, excision: Multiple (21) lymph nodes are negative for metastatic carcinoma. With available surgical materials, [AJCC pT3N1] (7th edition, 2010). Seen in consultation with
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diff --git a/output/text/b2b16e79-c988-420c-a843-25d285609a3f.txt b/output/text/b2b16e79-c988-420c-a843-25d285609a3f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b268eaa4a6f6f6ecaa72f867d527464d3a065821
--- /dev/null
+++ b/output/text/b2b16e79-c988-420c-a843-25d285609a3f.txt
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+
+--- Page 1 ---
+DIAGNOSIS (A) UTERUS AND CERVIX: Proliferative endometrium with adenomyosis.. Myometrial leiomyomata. Chronic cervicitis. (B) RIGHT KIDNEY: RENAL CELL CARCINOMA, CHROMOPHOBE TYPE, FUHRMAN NUCLEAR GRADE 3, (7.0 CM IN MAXIMUM DIMENSION). TUMOR IS LIMITED TO KIDNEY. Margins of resection are free of tumor.. No renal vein invasion is present.. GROSS DESCRIPTION (A) UTERUS AND CERVIX - A uterus (11.5 cm superior - inferior x 5.5 cm cornu-cornu x 5.7 cm anterior-posterior). There are twelve tan whorled nodules (ranging from 5.0 x 3. 0 x 3.0 cm to 0.4 x 0.3 x 0.3 cm) in the myometrium. The endometrium and myometrium is otherwise unremarkable (endometrium thickness 0.2 cm, myometrial thickness 2.3 cm). The cervix is unremarkable. SECTION CODE: A1, anterior cervix; A2, posterior cervix; A3, anterior lower uterine segment; A4, anterior endomyometrium; A5, posterior endomyometrium; A6-A8, three intramural nodules, anterior myometrium in each; A9, two intramural nodules in posterior myometrium; A10, one largest intramural nodule, representative sections. (B) RIGHT KIDNEY - Received is a radical nephrectomy specimen (12 x 6.0 x 5.5 cm) including the right kidney (11.0 x 5.0 x 5.5 cm), a segment of the renal artery, the renal vein, and ureter (9.0 cm in length x 0.6 cm in average diameter). No adrenal gland is identified. There is a 7.0 x 5.5 x 6.0 cm well-circumscribed tumor in the upper pole of the kidney. The tumor is tan-pink, soft and almost entirely necrotic. There are foci of hemorrhage both peripherally and centrally. The tumor does not invade the perinephric adipose tissue, renal sinus or renal vein. The tumor does not extend to Gerota's fascia. The adjacent renal parenchyma is tan-brown and otherwise unremarkable. The pelvicaliceal system is smooth and devoid of any lesions. No lymph nodes are identified in the hilum. Portions of the tumor have been submitted for possible electron microscopy. INK CODE: Blue - Gerota's fascia. SECTION CODE: B1, ureter, renal artery and renal vein margins; B2, B3, representative sections of tumor; B4, B5, representative sections of tumor with perinephric adipose tissue; B6, B7, representative sections of tumor with renal sinus and renal pelvis; B8, representative sections of uninvolved kidney. CLINICAL HISTORY Symptomatic fibroids and right renal mass.. SNOMED CODES
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diff --git a/output/text/b2e90679-d1d0-45b2-a56f-deb277655d80.txt b/output/text/b2e90679-d1d0-45b2-a56f-deb277655d80.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ac5a4143183c3546e7e27bbb51a87cb8d49a7d0b
--- /dev/null
+++ b/output/text/b2e90679-d1d0-45b2-a56f-deb277655d80.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+/cs-0-3 Carcioma mfltnatrg dluctel Nos 8500f3 t NOs C50.9 SiF: breast, 1/38/ Pathology Form Specimen Information Collected by: Date: Time: Preserved by: Date: -- Time: wSPECIMENTYPE#of samples provided.. Frozen Paraffin Block Blood/Serum/Plasma Slide Diseased Normal Diseased Normal Diseased Norma! Diseased Normal x x x Time to LN2 Time to Formalin Time to LN2 4.0 min min min KSEK PATHOLOGICALDESCRIPTIONUT Primary Tumor Organ Size Extension of Tumor Distance to NAT leest 9.5x X cm cm Lymph Nodes Location # Examined # Metastasized Axilla 0 Distant Metastasis Organ Detailed Location Size NO Pathological Staging No m c pTg Stage: ILA . Notes: Redacted UUID:273152AA-7B4C-4AE5-9231-1A3160058C74 TCGA-C8-A120-01A-PR 4
+
+--- Page 2 ---
+#: Microscopic Description .wwwww.HistologiclPaternwwwwwwrw. Cell Distribution + Structural Pattern  Diffuse + +  Streaming  Mosaic  Storiform Necrosis +  Fibrosis Lymphocytic Infiltration  Palisading Vascular Invasion  Cystic Degeneration Clusterized +  Bleeding  Alveolar Formation  Myxoid Change Indian File  Psammoma/Calcification   CellularDifferentiation  Squamous + Adenomatous Sarcomatous + Lymphomatous  Squamoid Cell  Glandular cell A Round Cell Large Cell Spindle Cell Cell Stratification Fibroblast Small Cel!  Keratin  Secretion Osteoblast  RS Cell/RS Like Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell Pear! Gland formation Myoblast Plasma Cell Cellular Differentiation: Well Moderate  Poor awsNuclearAppearanceawa. Nuclear Atypia: 0 1. II III Aniso Nucleosis + Hyperchromatism + Nucleolar Prominent + Multinucleated Giant Cell Mitotic Activity Nuclear Grade: +  Marker Result Value Date ER  Negative  Positive PR  Negative   Positive  Her-2/neu  Negative  Positive B-Cell Marker  Negative  Positive T-Cell Marker  Negative  Positive Other:  Negative  Positive Other:  Negative  Positive Fina! Pathology Report buctal Caruama Histological Diagnosis: makWae Grade: 10 Comments: r Principal Investigator Date
+
+--- Page 3 ---
+CONsOLIDaTeD DIAgnOsTIc paThOLOgy fORm* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION Diffuse STRUCTURAL PATTERN Mosaic Streaming Necrosis Storiform Lymphocytic Infiltration XFibrosis Vascular Invasion X Palisading Clusterized XCystic Degeneration Alveolar Formation Bleeding Indian File XMyxoid Change 2. Cellular features: Psammoma/Calcification Sguamous + Adenomatous Squamoid Cell + Sarcomatous Glandular cel! + Lymphomatous Spindle Cell Round Cell Cell Suratification  Large Cell  Keratin Fibroblast Secretion Small Cell Desmosome X Osteoblast RS Cell/RS Like Intracyt. Vacuole Lipoblast Pear! Gland formation Inflam. Cell K Myoblast Otherwise Specified: Plasma Cell D ss% dr ss% 2.Cellular Differentiation: Well  Moderately Poor 3.Nuclear Atypia: Nuckar Appearance Aniso Nucleosis II Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity Nuckar Grade V Nes, o-3 Comments: "Date ?CH USE ONLY). PATHOIO TEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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index 0000000000000000000000000000000000000000..b1a6ecaea2d0e2a16713b6435cc03293fde9e00b
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+RUN DATE: PAGE 1 RUN TIME: RUN USER: T PATIENT: ACCT #: LOC: U #: AGE/SX: ROOM: REG: REG DR: DOB: BED: DIS: STATUS: TLOC: SPEC #: RECD: STATUS: PERFORMED ATI COLL: TIME IN FORMALIN: CLINICAL INFORMATION: Pre-Op Diagnosis: Tag = axillary / tail specimen #3 UUID:389044F0-9D90-4639-8C42-C1A6EA816442 Remarks: TCGA-LL-A442-01A-PR Specimen(s) : A. Sentinel node #1 left breast Redacted B. Sentinel node #2 C. Left simple mastectomy MICROSCOPIC DIAGNOSIS ONE LYMPH NODE, SENTINEL NODE #1 LEFT BREAST, LYMPHADENECTOMY:S NO TUMOR SEEN IN MULTIPLE STEP SECTIONS STAINED WITH ROUTINE AND PAN KERATIN IMMUNOCHEMICAL STAINSS THREE LYMPH NODES, SENTINEL NODE #2, LYMPHADENECTOMY:S NO TUMOR SEEN IN MULTIPLE STEP SECTIONS STAINED WITH ROUTINE AND PAN KERATINS IMMUNOCHEMICAL STAINSS C. LEFT BREAST, TOTAL MASTECTOMY: TWO AREAS OF INFILTRATING DUCTAL CARCINOMA (IDENTICAL MORPHOLOGY) MODIFIED NOTTINGHAM HISTOLOGIC GRADE 2 OF 3: NUCLEAR SCORE 2 OF 3, TUBULARS FORMATION SCORE 3 OF 3, MITOTIC SCORE 1 OF 3 (TWO MITOTIC FIGURES PER SQUARE) MILLIMETER) LARGER TUMOR MEASURES 2.7 CM (pT2) EXTENSIVE DUCTAL CARCINOMA IN SITU, LOW GRADE WITH SOLID PATTERN SURGICAL MARGINS FREE OF TUMOR WITH NEAREST MARGIN TO INVASIVE TUMOR O.5 CM, THES DEEP MARGIN (RO) SEE COMMENT FOR SYNOPTIC REPORT IcDo 3 carCinoma,inF1Hq# ng ducta1,NO 5 tsoo J3 COMMENT(S) Sik: br<as+,N0s C5,q 81z3hiz rJ SURGICAL PATHOLOGY CANCER CASE SUMMARY - APPROVED BY COLLEGE OF AMERICAN PATHOLOGISTSS PROCEDURE: Total mastectomy LYMPH NODE SAMPLING: Sentinel lymph nodes SPECIMEN LATERALITY: Left HISTOLOGIC TYPE OF INVASIVE CARCINOMA: Invasive ductal carcinoma TUMOR SIZE Greatest dimension: 27 mm HISTOLOGIC GRADE: Glandular/tubular differentiation: score 3 Nuclear pleomorphism: score 2 Mitotic rate: score 1 ** CONTINUED ON NEXT PAGE **
+
+--- Page 2 ---
+RUN DATE: PAGE 2 RUN TIME: RUN USER: H PATIENT: (Continued) SPEC # COMMENT(S) (Continued) Overall grade: grade 2 TUMOR FOCALITY: Multiple foci of invasive carcinoma DUCTAL CARCINOMA IN SITU: DCIs is present, positive for EIC  MARGINS : Invasive carcinoma: Margins uninvolved by invasive carcinoma Distance from closest margin: 5 mm DCIS: Margins uninvolved by DCIS LYMPH NODES: Number of sentinel lymph nodes examined: 4 Total number of lymph nodes examined: 4 Number of lymph nodes with macrometastases: 0 Number of lymph nodes with micrometastases: 0 Number of lymph nodes with isolated tumor cells: PATHOLOGIC STAGING:S Primary tumor: pT2 Regional lymph nodes: Modifier: (sn) Category: pNO (i-) Distant metastasis:  not applicable ANCILLARY STUDIES: Estrogen receptor: Results: positive (1oo% of tumor cells with nuclear positivity) Progesterone receptor: Results: positive. (loo% of tumor cells with nuclear positivity) Immunoperoxidase studies: Results: equivocal (score 2+) In situ hybridization (Frsh):. Results: not amplified GROSS DESCRIPTION: A.  Received in formalin labeled with the patient's name and "sentinel node #l, left. breast" is a 2.0 x 1.3 x 0.9 cm nodular fatty tissue biopsy. The fat is trimmed, and there is a previously bisected, disrupted 1.5 x 0.8 x 0.6 cm lymph node present. The node is sectioned perpendicular to the long axis to be entirely submitted for sentinel lymph node protocol in cassette Al.. B.  Received in formalin labeled with the patient's name and "sentinel node #2, left breast" is a 2.3 x 1.5 x 1.2 cm nodular fatty lymph node. The fat is trimmed, and there are three small lymph nodes present which range up to 0.8 cm. The nodes are sectioned to be entirely submitted per sentinel lymph node protocol as labeled: B1 two lymph nodes with one lymph node bisected B2 largest lymph node serially sectioned perpendicular to the long axis  Received fresh for tissue banking labeled with the patient's name and "left simple. mastectomy" is a 481 gram, 17.0 x 16.0 x 4.5 cm fibrofatty breast. The breast is received with an overlying 9.5 x 3.0 cm black-brown skin ellipse. The ellipse has a central.. circular .3.0 cm areola which extends to the skin margin and a 1.0 cm central nipple.  The ** CONTINUED ON NEXT PAGE **
+
+--- Page 3 ---
+RUN DATE: PAGE 3 RUN TIME: RUN USER: SPEC #: PATIENT: (Continued) GROSS DESCRIPTION: (Continued) breast is absent of an axillary tail and consistent with a simple mastectomy specimen. The deep fascial margin is smooth and will be inked blue. The breast is serially sectioned from medial to lateral to have an inferior, 2.7 x 2.5 x 2.0 cm circumscribed red-brown mass. The mass is more closely associated with the lower outer quadrant. This larger mass comes to within 0.5 cm of the nearest inked deep margin..  This mass is inferior and comes to within 5.0 cm of the inferior margin, is 13 cm from the superior aspect, is at least 6.5 cm from lateral and 7.5 cm from medial.  There is a clip identified and a separate tumor site which is centrally located between the upper and lower inner quadrant..  This smaller tumor is 2.3 cm from the nearest deep margin and is 1.3 x 0.8 x 0.8 cm. The smaller tumor has a localization clip and is 11.0 cm from superior, is 6.5 cm from inferior, is approximately 4 cm from medial and at least 10 cm from lateral. The breast has diffuse dense white fibrous tissue with fibrocystic changes. The white fibrous tissue makes up between 60-75% of the parenchyma. Sections of tumor are sampled for tissue banking.. The specimen is sampled as labeled: C1 sections of nipple C2 areola at base of nipple. C3-C5 sections of large described brown septated mass sampled for tissue. banking in lower outer quadrant with cassette c3 being section of mass. nearest deep margin C6 deep margin overlying smaller mass with localization clip. C7, C8 smaller tumor entirely submitted C9 upper outer quadrant C10 lower outer quadrant (quadrant closest to large tumor mass). C11 upper inner quadrant (quadrant associated with smaller tumor with localization clip) C12 lower inner quadrant sampled INTRAOPERATIVE CONSULTATION: IMMEDIATE GROSS EVALUATION C, LEFT BREAST: TUMOR PROCESSED FOR TUMOR BANKING Image Image Image Signed (signature on file) *+ END OF REPORT **
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diff --git a/output/text/b34b3886-f0ed-40c0-a589-ffdbdb402a02.txt b/output/text/b34b3886-f0ed-40c0-a589-ffdbdb402a02.txt
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index 0000000000000000000000000000000000000000..c2377c64474aefc893f9b29c2c4ac830947cba9d
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+SURGICAL PATHOLOGY REPORT Clinical Diagnosis & History:. Colon carcinoma. Specimens Submitted: 1: SP: RIGHT COLON; HEMICOLECTOMY DIAGNOSIS: 1. SP: RIGHT COLON; HEMICOLECTOMY: Tumor Type: Adenocarcinoma Histologic Grade: Moderately differentiated Tumor Location: Ascending colon Tumor Size: Length is 3.5 cm Width is 3.1 cm Maximal thickness is 0.5 cm. Tumor Budding: Absent Increased Tumor Infiltrating Lymphocytes:. Absent Precursor Lesions: Tubulovillous adenoma Deepest Tumor Invasion: Muscularis propria Gross Tumor Perforation: Not identified Lymphovascular Invasion: Not identified Large Venous Invasion: Not Identified Perineural Invasion:  Not identified Surgical Margins: Free of tumor Polyps/Mucosa Dysplasia (away from the carcinoma): Not Identified Non-Neoplastic Bowel: Unremarkable ** Continued on next page **
+
+--- Page 2 ---
+Page 2 of 3 Appendix: Unremarkable Lymph Nodes: Number with metastasis: 0 Total number examined: 28 Tumor c deposits in pericolorectal soft tissue: Not Identified. Tumor Staging (AJcc 7th Edition): pT2 (Tumor invades muscularis propria). Lymph Node Stage (AJcc 7th Edition): N0 (No regional lymph node metastasis). I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Gross Description: 1. The specimen is received fresh, labeled "Right colon" and consists of a segment of terminal ileum and colon with attached omentum. The terminal. ileum measures 14.5 cm in length and 3.0 cm in circumference at the proximal. resection margin, which is inked violet.. The remaining colon measures 26.3 in length with a circumference of 6.6 cm at the distal resection margin, which is inked orange. The attached appendix measures 6.1 cm in length and. averages 0.4 cm in diameter.  The appendiceal and intestinal serosa is pink. and smooth. Lobulated fatty tissue spans the length of the specimen measuring up to 5.2 cm in thickness.  The attached omentum measures 7 x 6 x 1.3 centimeters.  The specimen is opened to reveal a pink-tan fungating mass measuring 3.5 cm in length and 3.1 cm in width. The mass is located in the ascending colon, 4.5 cm from the ileocecal valve, 17.8 cm from the proximal. margin and 16.1 cm from the distal margin. Sectioning shows a depth of invasion of 0.2 cm grossly.. A tatoo is identified adjacent to the tumor. Multiple diverticula are present. The remaining mucosa is unremarkable. The attached adipose tissue is submitted for lymph node dissection, and all. identified lymph nodes are submitted. Representative sections of the. specimen are submitted for permanent sections and for Tps.. Summary of sections: proximal margin shave D - distal margin shave T tumor, in toto A - appendix representative sections. RSI -representative sections, : ileum RSC representative sections, colon. ** Continued on next page **
+
+--- Page 3 ---
+Page 3 of 3 DI - diverticula O-omentum LN - lymph nodes BLN - bisected lymph nodes Summary of Sections: Part 1:  SP: RIGHT COLON; HEMICOLECTOMY Block Sect. Site PCs 2 2 1 1 2 8 LN 24 11 0 11 rsc rsi 8 t ** End of Report
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+UUID:B6B4DCFE-F044-44D6-B890-EF71E6981E82 TCGA-LL-A5YP-01A-PR Redacted RUN DATE: PAGE 1 RUN TIME: RUN USER:  Inquiry PATIENT LOC: U # AGE/SX: REG DR:  ROOM : REG: DOB: BED: DIS: STATUS : TLOC: SPEC #: COLL : TIME IN FORMALIN: 77:14 hrs. CLINICAL INFORMATION: Pre-Op Diagnosis: Breast CA Remarks: Specimen(s) : A. Left breast tcd-0-3 B. Left sentinel node.  Right breast and axillary contents. crc mome,ductal inf, Itrctiny hitg C. S50d/3 Site ? BreastnbS~c5o.9 MICROSCOPIC DIAGNOSIS A 4/z(i3 A BREAST. LEFT. SIMPLE MASTECTOMY: INVASIVE GRADE 3 DUCTAL CARCINOMA WITH EXTENSIVE TUMOR NECROSIS AND ASSOCIATEDS HIGH-GRADE DUCTAL CARCINOMA IN SITU (DCIS) WITH COMEDO NECROSIS TUMOR MEASURES 1.8 CM IN GREATEST DIMENSION (pT1c) ONE (1) OF TWO (2) TAIL OF BREAST/LOW AXILLARY LYMPH NODES POSITIVE FOR) METASTATIC CARCINOMA MEASURING 7 MM IN EXTENT WITHOUT EXTRACAPSULAR EXTENSION HEALING WOUND REACTION CONSISTENT WITH PREVIOUS NEEDLE BIOPSY NO DEFINITIVE PERITUMORAL ANGIOLYMPHATIC INVASION IDENTIFIED MARGINS NEGATIVE WITH CLOSEST MARGIN DEEP MEASURING 5 MM ADDITIONAL PATHOLOGIC FINDINGS: NEUROFIBROMATOSIS PROLIFERATIVE FIBROCYSTIC CHANGES FIBROADENOMA (SMALL) B LEFT AXILLARY SENTINEL LYMPH NODE. EXCISION: ONE (1) SENTINEL NODE NEGATIVE FOR METASTATIC CARCINOMA BY ROUTINE LIGHTS MICROSCOPY AND CYTOKERATIN (PANK+) IMMUNOSTAIN TWO (2) NONSENTINEL LYMPH NODES NEGATIVE FOR METASTATIC CARCINOMAS C. BREAST, RIGHT, MODIFIED RADICAL MASTECTOMY: INVASIVE GRADE 3 DUCTAL CARCINOMA MEASURING 4 CM WITH EXTENSIVE TUMOR NECROSIS (pT2) ASSOCIATED HIGH-GRADE DUCTAL CARCINOMA IN SITU (DCIS) WITH COMEDO NECROSIS: NOT EXTENSIVE) TUMOR INVADES DERMIS WITHOUT ULCERATION TUMOR DOES NOT INVADE DEEP SKELETAL MUSCLE TWO (2) OF 12 AXILLARY LYMPH NODES POSITIVE FOR METASTATIC CARCINOMA WITHS EXTRANODAL CAPSULAR EXTENSION PRESENT AND FOCAL AREA SUSPICIOUS FOR PERINODAL VENOUS INVASION MARGINS NEGATIVE WITH CLOSEST MARGIN TO INVASIVE TUMOR SUPERIOR (2 MM) AND TO DCIS MEDIAL (4 MM) ADDITIONAL PATHOLOGIC FINDINGS: 2.5 CM FIBROADENOMA  NEUROFIBROMATOSIS ** CONTINUED ON NEXT PAGE **
+
+--- Page 2 ---
+PAGE 2 RUN DATE: Specimen Inquiry RUN TIME: RUN USER: (,Continued) SPEC #: PATIENT: : (Continusd)  MICROSCOPIC DIAGNOSIS PROLIFERATIVE FIBROCYSTIC CHANGES COMMENT(S) Bilateral poorly differentiated ductal carcinomas are present. Both have positive axillary lymph nodes with the positivs left axillary node present in the tail of the breast region of the simple mastectomy specimen. Of note is that the sentinel lymph node on the left side was found to be negative for carcinoma. High-grade Dcis with comedo necrosis is associated with both tumors. most prominent on the left side where in some areas it is difficult to distinguish the in situ from the invasive component. The left breast carcinoma is associated with numerous amorphous chunk-like microcalcifications. left and The previous core needle biopsy material from these tumors ( right) were evaluated with a breast prognostic panel. The carcinomas were both. found to be weakly positive for estrogen receptor and with discordant findings with regards to HER2/neu by immunohistochemical stain and FIsh analysis. Due to the extensive necrosis present on the previous core naedle biopsy. both tumors are being further evaluated for HER2/nau status. As this case was received in the department such that it does not fall within the 6-48 hour time frame for formalin fixation and due to some difficulty in sorting out the invasive component from the Dcis component in sections of the left breast mass. the positive lymph node from the left breast with 5 hours of formalin fixation and two sections of the tumor from the right breast (block c1 with 5 hours of formalin fixation and block c5 with 77 hours of formalin fixation) are being further evaluated for HER2/nsu status by immunohistochemical stains and possible FIsh. The results of these studies will be reported separately as an addendum.. CAP Protocol for the Examination of Specimens From Patiants With Invasive Carcinoma of the Breast Based on AJCC/UIcC TNM. 7th edition Specimen A - Left Breast Carcinoma: Total mastectomy PROCEDURE: Sentinel lymph nodes and lymph nodes present LYMPH NODE SAMPLING: within the breast specimen Left LATERALITY : Invasive ductal carcinoma (Nos) HISTOLOGIC TYPE: Greatest dimension: 1.8 cm TUMOR SIZE: Glandular Differentiation: Score 3 HISTOLOGIC GRADE (NOTTINGHAM) : Nuclear Pleomorphism: Score 3 Mitotic Rate: Score 3 Overall Grade: Grade 3 Single focus of invasive carcinoma TUMOR FOCALITY: DCIS is present DUCTAL CARCINOMA IN SITU: Margins uninvolved by invasive carcinoma and MARGINS : DCIS ** CONTINUED ON NEXT PAGE **
+
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+RUN DATE: PAGE 3 RUN TIME: Specimen Inquiry RUN USER: SPEC #: PATIENT : (Continued) COmment(s) (Continued) Distance from closest margin: 5 mm (deep) LYMPH NODES: Number of sentinel lymph nodes examined: 1 Total number of lymph nodes examined (sentinel and nonsentinel): 5 Number of sentinel lymph nodes with macrometastases: 1 Number of lymph nodes with micrometastases (>0.2 mm to 2 mm and/or >200 cells): 0 Number of lymph nodes with isolated tumor cells (0.2 mm and 200 cells): 0 Number of lymph nodes without tumor cells identified: 4 PATHOLOGIC STAGING: Primary Tumor: pT1c Regional Lymph Nodes: pN1a Distant Metastasis: Not applicable ANCILLARY STUDIES: ER: Positive (26% of tumor cells weak staining intensity) PR: Negative HER2 Immunoperoxidase Studies: 2+ HER2 FISH: Not amplified NOTE : Results are on previous core biopsy material Specimen C - Right Breast Carcinoma PROCEDURE : Total mastectomy LYMPH NODE SAMPLING: Axillary dissection LATERALITY: Right HISTOLOGIC TYPE: Invasive ductal carcinoma (nOs) TUMOR SIZE: Greatest dimension: 4 cm HISTOLOGIC GRADE (NOTTINGHAM) : Glandular Differentiation: Score 3 Nuclear Pleomorphism: Score 3 Mitotic Rate: Score 3 Overall Grade: Grade 3 TUMOR FOCALITY: Single focus of invasive carcinoma DUCTAL CARCINOMA IN SITU: DCIS is present MICROSCOPIC EXTENT OF TUMOR: Skin: Invasive carcinoma directly invades into the dermis without skin ulceration MARGINS : Invasive carcinoma: Margins uninvolved by invasive carcinoma Distance from closest margin: 2 mm (superior) Ductal Carcinoma In Situ: Margins uninvolved by DCIS Distance from closest margin: 4 mm (medial) LYMPH NODES: Number of sentinel lymph nodes examined: 0 Total number of lymph nodes examined (sentinel and nonsentinel): 12 Number of sentinel lymph nodes with macrometastases: 2 ** CONTINUED ON NEXT PAGE **
+
+--- Page 4 ---
+PAGE 4 RUN DATE: Specimen Inquiry RUN TIME: RUN USER: (Continued) PATIENT: SPEC #: (Continued) COmmEnt(S ) Number of lymph nodes with. micrometastases (>0.2 mm to 2 mm and/or >200 cells): 0 Number of lymph nodes with isolated tumor cells (0.2 mm and 200 cells): 0 Number of lymph nodes without tumor cells identified: 10 Primary Tumor: pT2 PATHOLOGIC STAGING: Regional Lymph Nodes: pN1a Distant Metastasis: Not applicable. ER: Positive (8% of tumor cells) weak staining. ANCILLARY STUDIES: intensity) PR: Negative HER2 Immunoperoxidase Studies: Negative (1+). In Situ Hybridization: Amplified Average Number of HER2 gene copies/cell: 5.9. Average Number of chromosomes 17/cell: 1.8 Note:  Performed on core needle biopsy GROSS DESCRIPTION: A. a 413 gram. 27.0 x 12.5 x 3.0 cm fibrofatty breast. The breast has an overlying 24.0 x 12.5 cm portion of brown/black skin. The skin has a central to slightly eccentric 5.5 x 4.5 cm areola and a somewhat contral 1.5 cm nipple. The skin surface has multiple papules with no scars or lesions identified. The deep margin is predominantly smooth and is inked blue. The. breast is serially sectioned from medial to lateral to have a central/lateral 2.0 x 1.0 x 1.4 cm indurated to centrally necrotic hemorrhagic to yellow appearing tumor mass. The tumor mass is at least 18 cm from medial. is approximately 5 cm from lateral. is approximately 5 cm from superior and 5 cm from inferior. The tumor is 0.2 cm from the deep  for margin and the deep margin slides aasily over ths mass. Sections of tumor are sampled. Tissue Banking. A large. 1.4 x 1.0 x 0.8 cm. nodular.lymph node is identified in the lateral most aspect of the breast tissue. Two additional smaller lymph nodes are present. section of the large lymph node is sampled for frozen section diagnosis. The two smaller nodes are 0.4 and 0.8 cm. The remainder of the breast tissue is diffusely fibrous with. fibrocystic change. There is indurated fibrocystic change adjacent to the tumor and ranges up to an additional 2.0 cm. The white fibrous tissue makes up between 75 and 80% of the parenchyma.  There is diffuse ecchymotic hemorrhage lateral to the tumor predominant in the lower/outer quadrant. The breast tissue is diffusely nodular. however. no additional discrete tumor like mass is identified. Representative sections are sampled to be submitted. following overnight fixation for a repeat of tumor markers. The remainder of the specimen Representative sections are sampled as labeled in ths following. will be held for fixation. cassettes: A1 frozen section residue A2 ramainder of the lymph node A3 sliver of tumor ** CONTINUED ON NEXT PAGE **
+
+--- Page 5 ---
+RUN DATE: PAGE 5 RUN TIME: Specimen Inquiry. RUN USER: SPEC #: PATIENT: (Continued) GROSS DESCRIPTION:S (Continued) All these sections will be submitted following overnight fixation. The remainder of the sections will be submitted following further fixation as labeled: A4-A5 sections of nipple. A6 en face areola sectioned. A7-A8 full cross sections of tumor to deep margin A9 smaller lymph node submitted in toto A10 area of indurated nodularity adjacent to tumor A11 upper/outer quadrant sampled A12 lower/outer quadrant sampled (quadrant most closely associated with tumor) A13 upper/inner quadrant sampled A14 lower/inner quadrant sampled B.  Part B is received in formalin. labeled with the patient's name and "left sentinel node". Received is a 3.5 x 2.5 x 0.8 cm aggregate of yellow adipose. The adipose is sectioned to have three nodular lymph nodes which range from 0.5 cm to a linear 1.7 x 0.6 x 0.4 cm. The larger node has been designated in the OR as the sentinel node. Each node is sectioned perpendicular to the long axis to be entirely submitted per santinel lymph node protocol with the sentinel node submitted in B1-B2 and the additional nodes submitted separately B3-B4. C. Received fresh for Tissue Banking, labeled with the patient's name and "right breast with axillary node contents" is a 445 gram. 23.0 x 13.0 x 3.0 cm fibrofatty breast. The breast has an overlying 22.5 x 11.0 cm black/brown skin ellipse. The ellipse has multiple raised papules across the surface and an eccentrically. medially located 6.0 x 5.0 cm areola with a 1.3 cm mildly flattened nipple. No scars or lesions are identified on the skin surface. The breast is received with a 9.0 x 4.5 x 3.0 cm axillary tail and the specimen is consistent with a modified radical mastectomy specimen. The deep fascial plane is smooth and somewhat irregular. The deep fascial plane will be inked blue and the breast is serially sectioned from medial to lateral to have a medially located 4.0 x 3.7 x 3.0 cm tumor mass. The mass is 0.5 cm from the nearest inked deep margin. There is a portion that comes within 0.6 cm of superior, 0.8 cm of medial and is 0.4 cm from inferior at the medial most tip of the breast specimen. A second spherical 2.0 cm mass is located in the upper/outer quadrant. This mass is 0.4 cm from the deep margin and the deep margin slides easily over the mass. The second mass is approximately 2.5 cm from superior. is 12.5 cm inferior. is 15 cm from medial and 8 cm from lateral. Further sectioning of the large mass shows it to focally extend to the superior peripheral margin. The remainder of the breast parenchyma has diffuse dense white fibrous tissue with diffuse fibrocystic change. The fibrous tissue makes up between 80 and 90% of the parenchyma. No additional discrete tumor like masses are identified. The axillary tail is sectioned to have multiple nodular lymph nodes. The nodes include tumor replaced nodes and range up to a positive. 4.0 x 2.5 x 2.5 the necrosis in the large tumor mass. Ropresentative sections are sampled as labeled in the following cassettes: C1 sliver of tumor which will be submitted following overnight tissue processing for tissue markers C2 nipple C3 en face section of areola C4 section of large tumor mass to deep margin C5-C6 large tumor mass to superior/medial peripheral margins ** CONTINUED ON NEXT PAGE **
+
+--- Page 6 ---
+PAGE 6 RUN DATE : Specimen Inquiry RUN TIME: RUN USER: (Cont inued) PATIENT : SPEC #: GROSS DESCRIPTION: (Continued) C7 -C8 tumor to skin. C9 cross section of large tumor mass. C10 deep margin nearest smaller tumor mass. C11-C12 smaller tumor mass sampled C13 upper/outer quadrant (quadrant most closely associated with smaller. tumor mass) C14 lower/outer quadrant sampled C15 upper/inner quadrant sampled (quadrant most closely associated with. large tumor mass) C16 lower/inner quadrant C17-C18 whole axillary lymph nodes C19 one whole lymph node and one lymph node (positive). C20 largest lymph node sampled KRM/m f INTRAOPERATIVE CONSULTATION: FROZEN SECTION DIAGNOSIS LEFT BREAST: A TAIL OF BREAST / AXILLARY LYMPH NODE POSITIVE FOR METASTATIC CARCINOMA PRIMARY TUMOR JUDGED ADEQUATE FOR TISSUE BANKING WITH PORTION OF NEOPLASTIC TISSUE PROVIDED TO TISSUE BANK COORDINATOR RESULTS GIVEN TO PHOIO DOCUMENTATION Image Image Image Image Signed ** END OF REPORT ** (Bi1cturl diseue) m 3|s|13
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diff --git a/output/text/b3a06edc-8c73-4692-b334-64c41b7088ad.txt b/output/text/b3a06edc-8c73-4692-b334-64c41b7088ad.txt
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+--- Page 1 ---
+ UUID:C59230D8-8DF2-460B-9774-629161D1DA20 Page I of 8 TCGA-SX-A7SM-01A-PR Redacted Result Type: Surgical Pathology Report Result Date: IDo3 Performed By: Encounter  info: 8263 C44.9 Surgical Pathology Report *Final* OtO i0f4/13 Surgical Pathology Report REVISED REPORT DIAGNOSIS: AMENDED REPORT Report is amended to correct formatting issues. The diagnosis remains unchanged. CASE AMENDED: to report the final diagnosis on parts A. and B after outside consultation.. A. Left renal vein, thrombectomy:. Papillary renal cell carcinoma.. B. Left kidney and para-aortic lymph nodes:. wall of renal vein and into perinephric/periadrenal adipose tissue.. BCR Margins, free of tumor. Metastatic carcinoma to multiple hilar lymph nodes. Renal synoptic report: Procedure/laterality: Left radical nephrectomy and para-aortic. lymphadenectomy. Histologic type: Papillary renal cell carcinoma, type 2. Nuclear grade (Fuhrman, 1-4): 4.. Tumor size: 4.2 x 3.5 x 3.5 cm. Tumor site: Lower pole. Tumor focality: Unifocal.. Sarcomatoid features: Present (5-10%). Tumor necrosis: Present (10% of tumor).. Macroscopic extent of tumor: Tumor involves renal vein and. perinephric (including periadrenal) adipose tissue. Microscopic tumor extension: Tumor involves wall of renal vein and invades perinephric and periadrenal adipose tissue. Surgical margins: Free of tumor.. Lymphovascular invasion: Present. Lymph nodes: Metastatic carcinoma to multiple (matted) hilar lymph nodes. No extranodal extension identified. Pathologic findings in nonneoplastic kidney: Changes compatible. with embolization. Pathologic staging (AJcc 2010): pT3a, pN1.. Biorepository sample: Tumor present (loo% of all tumor samples.
+
+--- Page 2 ---
+Page 2 of 8 taken). Blocks containing malignancy suitable for additional testing: B4, B5 and Bll. C. Left common iliac lymph nodes, excision: Metastatic carcinoma to one lymph node (l/1).. No extranodal extension identified.. D. Descending colon and sigmoid, segmental resection: Segment of colon with serosal fibrovascular adhesions.. Negative for malignancy. E. Suprarenal para-aortic lymph nodes, excision: Metastatic carcinoma to one of one lymph node (l/1). No extranodal extension identified. F. Inter-aortic lymph node, excision: Metastatic carcinoma to multiple matted lymph nodes. No extranodal extension identified. G. Left common iliac lymph node #2, excision:. Metastatic carcinoma to one lymph node (1/1). No extranodal extension identified. DIAGNOSIS COMMENT: This supplemental report is being issued to provide the final diagnosis for parts A and B after consultation with and after performing a Fish study to rule out Xpll.2. translocation-associated renal cell carcinoma. The tumor exhibits a predominant papillary architecture, lined by cells with a variably eosinophilic to clear cytoplasm. Areas with solid pattern of growth, also with clear cell features, are present Scattered calcifications are seen. Within the solid areas, some tumor cells exhibit spindling and atypia, compatible with focal sarcomatoid de-differentiation. Immunohistochemical stains for the tumor cells are positive for cytokeratin 7, EMA (focal), racemase (p504s), vimentin and pAx-8 (focal). A stain for p63 is negative. The overall cytoarchitectural features and immunohistochemical profile are compatible with a papillary renal cell carcinoma, type 2. Although focal areas are suggestive of Xpll translocation carcinoma, the immunohistochemical profile (positivity for EmA and cytokeratin 7) do not support this impression, and Fish for the detection of rearrangement of the TFe3 gene locus at chromosome Please see their report for full Xpll.2 is negative. details. Report electronically signed by Transcribed by: AMENDMENTs: (Previous Signout Date: Revision Description: See final report for amendment reason. ..Previous Diagnosis.... CASE AMENDED: to report the final diagnosis on parts A. and B after outside consultation. A. Left renal vein, thrombectomy: Papillary renal cell carcinoma. B. Left kidney and para-aortic lymph nodes: Procedure/laterality: Left radical nephrectomy and para-aortic lymphadenectomy. Histologic type: Papillary renal cell carcinoma, type 2.
+
+--- Page 3 ---
+Page 3 of 8 Nuclear grade (Fuhrman,. 1-4): 4. Tumor size: 4.2 x 3.5 x 3.5 cm. Tumor site: Lower pole.. Tumor focality: Unifocal.. Sarcomatoid features: Present (5-10%). Tumor necrosis: Present (l0% of tumor). Macroscopic extent of tumor: Tumor involves renal vein and perinephric (including periadrenal) adipose tissue. Microscopic tumor extension: Tumor involves wall of renal vein and invades perinephric and periadrenal adipose tissue. Surgical margins: Free of tumor. Lymphovascular invasion: Present. Lymph nodes: Metastatic carcinoma to multiple hilar lymph nodes. No extranodal extension identified. Pathologic findings in nonneoplastic kidney: Changes compatible with embolization. Pathologic staging (AJcc 2010): pT3a, pN1. Biorepository sample: Tumor present (l0o% of all tumor samples taken).. Blocks containing malignancy suitable for additional. testing: B4, B5 and B11.. C. Left common iliac lymph nodes, excision: Metastatic carcinoma to one lymph node (1/1). No. extranodal extension identified. D. Descending colon and sigmoid, segmental resection: Segment of colon with serosal fibrovascular adhesions. Negative for malignancy. E. Suprarenal para-aortic lymph nodes, excision: Metastatic carcinoma to one of one lymph node (1/1). F. Inter-aortic lymph node, excision: Metastatic carcinoma to multiple matted lymph nodes. No extranodal extension identified. G. Left common iliac lymph node #2, excision: Metastatic carcinoma to one lymph node (1/l). No. extranodal extension identified. .Previous Diagnosis Comment.. This supplemental report is being issued to provide the final diagnosis for parts A and B after consultation with and after performing a FIsh study to rule out Xpll.2 translocation-associated renal cell carcinoma. The tumor exhibits a predominant papillary architecture, lined by cells with a variably eosinophilic to clear cytoplasm. Areas with solid pattern of growth, also with clear cell features, are present. Scattered calcifications are seen. Within the solid areas, some tumor cells exhibit spindling and atypia, compatible with focal sarcomatoid de-differentiation. Immunohistochemical stains for the tumor cells are positive for cytokeratin 7, EMA (focal), racemase (p504s), vimentin and pAx-8 (focal). A stain for p63 is negative. The overall cytoarchitectural features and immunohistochemical profile are compatible with a papillary renal cell carcinoma, type 2. Although focal areas are suggestive of Xpll translocation carcinoma, the immunohistochemical profile (positivity for EmA and cytokeratin 7) do not support this impression, and Fish for the detection of rearrangement of the TFE3 gene locus at chromosome Xpll.2 is negative. Please see their report for full
+
+--- Page 4 ---
+Page 4 of 8 details. AMEnDMENTs: (Previous Signout Date: Revision Description: Please see Final Report for amendment reason ..Original Diagnosis... A. Left renal vein, thrombectomy: Renal cell carcinoma, subtype pending consultation. B. Left kidney and para-aortic lymph nodes: Procedure/laterality: Left radical nephrectomy and para-aortic lymphadenectomy. Histologic type: Renal cell carcinoma, subtype pending (See Comment) Nuclear grade (Fuhrman, 1-4): consultation. 3. Tumor size: 4.2 x 3.5 x 3.5 cm. Tumor site: Lower pole. Tumor focality: Unifocal. Sarcomatoid features: Not identified. Tumor necrosis: Present (l0% of tumor). Macroscopic extent of tumor: Tumor involves renal vein and perinephric (including periadrenal) adipose tissue. Microscopic tumor extension: Tumor involves wall of renal vein and invades perinephric and periadrenal adipose tissue. Surgical margins: Free of tumor. Lymphovascular invasion: Present. Lymph nodes: Metastatic carcinoma to multiple hilar lymph nodes. No extranodal extension identified. Pathologic findings in nonneoplastic kidney:  Changes compatible with embolization. Pathologic staging (AJcc 2010): pT3a, pN1. Biorepository sample: Tumor present (lo0% of all tumor samples taken). Blocks containing malignancy suitable for additional testing: B4, B5 and Bll. C. Left common iliac lymph nodes, excision: Metastatic carcinoma to one lymph node (l/1). No extranodal extension identified. D. Descending colon and sigmoid, segmental resection: Segment of colon with serosal fibrovascular adhesions. Negative for malignancy. E. Suprarenal para-aortic lymph nodes, excision: Metastatic carcinoma to one of one lymph node (l/1). F. Inter-aortic lymph node, excision: Metastatic carcinoma to multiple matted lymph nodes. No extranodal extension identified. G. Left common iliac lymph node #2, excision: Metastatic carcinoma to one lymph node (1/1). No extranodal extension identified. .Original Diagnosis Comment... The morphologic features of the tumor are unusual. The tumor exhibits a predominant papillary architecture, lined by cells with a
+
+--- Page 5 ---
+Page 5 of 8 variably eosinophilic to clear cytoplasm. Areas with solid pattern of growth, also with clear cell features, are present. Scattered calcifications are seen. Within the solid areas, some tumor cells exhibit spindling and atypia; however, no definitive sarcomatoid. de-differentiation is identified. Immunohistochemical stains for the tumor cells are positive for cytokeratin 7, EMA (focal), racemase (p504s), vimentin and pAx-8 (focal). A stain for p63 is negative.. The overall cytoarchitectural features and immunohistochemical profile are compatible with a renal cell carcinoma; subtyping of the tumor is difficult. The tumor predominantly exhibits features of a papillary renal cell carcinoma (type 2). Although focal areas are suggestive of Xpll translocation carcinoma, the immunohistochemical profile (positivity for EmA and cytokeratin 7) do not support this impression. This case will be sent to. for expert consultation. Their findings and final diagnosis will be reported in a supplemental report. ...Original Gross Description. A. Received fresh labeled and "tumor thrombus. left renal vein," are two portions of soft gray-tan somewhat friable tissue, 1.5 cm and 1.8 cm. Sampled in one cassette labeled B. Received fresh labeled and "left kidney. and periaortic nodes" is a radical nephrectomy specimen, 1050 g including the surrounding perinephric fat and attached periaortic lymph node tissue. The kidney without attached fat is 295 g and 12.5 x 8 x 6.5 cm. The attached ureter is 10 x 1 cm. The kidney has a circumscribed exophytic mass in the lower pole that is 4.2 x 3.5 x 3.5 cm. The mass grossly appears to extend into the adjacent perinephric fat. There is not definitive gross extension beyond Gerota's fascia. The tumor does not definitively extend into the renal sinus fat. The hilar vasculature and intrarenal vessels are thrombosed. The renal vein also contains thrombus and is somewhat suggestive of tumor thrombus. The leading edge of the thrombus within the renal vein is rounded and the margin is not grossly involved by tumor. Within the hilar soft tissue and adjacent s tissue is a matted mass of tumor-replaced lymph nodes. This is up to 14 x 5.5 x 5 cm. Additional tumor nodules are identified within the perinephric fat and immediately adjacent to the attached adrenal gland. The renal pelvis is hyperemic and slightly granular; however, there is no grossly evident mass. Sampled in nineteen cassettes labeled Bl) Ureter and vascular margin, B2-B5). renal tumor samples; B6) longitudinal section of renal vein with apparent tumor thrombus; B7) additional hilar vasculature with thrombus; B8) perinephric fat nodule; B9-Bll) periaortic/hilar lymph node samples; B12) renal pelvis; B13-B14) adrenal gland with apparent tumor nodules and surrounding fat; B15) grossly nonneoplastic kidney; Bl6) mirror image of biorepository sample, kidney tumor (sample 1 not inked, sample 2 inked); B17) mirror image of biorepository samples, lymph node metastasis (three separate samples, differentiated with no ink, blue ink, and black ink; B18) mirror image of biorepository sample, grossly nonneoplastic kidney; B19) additional samples of ureter. Samples of tissue are submitted
+
+--- Page 6 ---
+Page 6 of 8 for C. Received fresh labeled and "left common iliac lymph node" is a nodular flesh tan-gray portion of tissue, 4.5 x 2.5 x 2.5 cm. Sampled in two cassettes labeled. D. Received fresh labeled and "descending colon and sigmoid" is a segment of large bowel, 43 cm in length and up to 4 cm in external diameter. The serosal surfaces are predominately glistening and smooth with focal areas of possible adhesions. The mucosa intact. There is no mucosal or pericolic mass D1) identified. Sampled in three cassettes labeled. Sample adjacent to each surgical end; D2-d3) additional sections. E. Received fresh labeled and "suprarenal periaortic lymph nodes" are two apparent lymph nodes, 1.8 cm and 2.5 cm in maximum dimension. A sample of each is submitted in one cassette labeled F. Received fresh labeled " and "inter aortic lymph nodes" is a matted mass of apparent lymph nodes replaced by tumor, 7.5 x 4 x 2.5 cm. Sampled in three cassettes labeled G. Received fresh labeled " and "left common. iliac lymph node number 2" are two irregular portions of apparent 1.2 cm, and 3.5 x 2 x tumor-replaced lymph node tissue, 2.5 x 1.5. 1.5 cm. Sampled in two cassettes labeled CLINICAL INFORMATION: Renal mass. SPEcImEn(S) : A:Left renal vein thrombus tumor B:Left kidney and para aortic lymph nodes C:Left common iliac lymph nodes D:Descending colon and sigmoid E:Supra renal para aortic lymph nodes F:Inter aortic lymph nodes G:Left common iliac lymph nodes GROSS DESCRIPTION: Performed by A. Received fresh labeled " and "tumor thrombus. left renal vein," are two portions of soft gray-tan somewhat friable tissue, 1.5 cm and 1.8 cm. Sampled in one cassette labeled B. Received fresh labeled and "left kidney and periaortic nodes" is a radical nephrectomy specimen, 1050 g including the surrounding perinephric fat and attached periaortic lymph node tissue. The kidney without attached fat is 295 g and 12.5 x 8 x 6.5 cm. The attached ureter is 10 x 1 cm. The kidney has a
+
+--- Page 7 ---
+Page 7 of 8 circumscribed exophytic mass in the lower pole that is 4.2 x 3.5 x 3.5 cm. The mass grossly appears to extend into the adjacent perinephric fat. There is not definitive gross extension beyond Gerota's fascia. The tumor does not definitively extend into the renal sinus fat. The hilar vasculature and intrarenal vessels are thrombosed. The renal vein also contains thrombus and is somewhat suggestive of tumor thrombus. The leading edge of the thrombus within the renal vein is rounded and the margin is not grossly involved by tumor. Within the hilar soft tissue and adjacent s tissue is a matted mass of tumor-replaced lymph nodes. This is up to 14 x 5.5 x 5 cm. Additional tumor nodules are identified within the perinephric fat and immediately adjacent to the attached adrenal gland. The renal pelvis is hyperemic and slightly granular; however, there is no grossly evident mass. Sampled in nineteen cassettes labeled . B1) Ureter and vascular margin, B2-B5) renal tumor samples; B6) longitudinal section of renal vein with apparent tumor thrombus; B7) additional hilar vasculature with thrombus; B8) perinephric fat nodule; B9-B11) periaortic/hilar lymph node samples; B12) renal pelvis; B13-B14) adrenal gland with apparent tumor nodules and surrounding fat; B15) grossly nonneoplastic kidney; B16) mirror image of biorepository sample, kidney tumor (sample 1 not inked, sample 2 inked); B17) mirror image of biorepository samples, lymph node metastasis (three separate samples, differentiated with no ink, blue ink, and black ink; B18) mirror image of biorepository sample, grossly nonneoplastic kidney; B19) additional samples of ureter. Samples of tissue are submitted for C. Received fresh labeled and "left common iliac lymph node" is a nodular flesh tan-gray portion of tissue, 4.5. x 2.5 x 2.5 cm. Sampled in two cassettes labeled D. Received fresh labeled and "descending colon and sigmoid" is a segment of large bowel, 43 cm in length and up to 4 cm in external diameter. The serosal surfaces are. predominately glistening and smooth with focal areas of possible adhesions. The mucosa intact. There is no mucosal or pericolic mass identified. Sampled in three cassettes labeled D1) Sample adjacent to each surgical end; D2-d3) additional sections. E. Received fresh labeled and "suprarenal periaortic lymph nodes" are two apparent lymph nodes, 1.8 cm and 2.5 cm in maximum dimension. A sample of each is submitted in one cassette labeled F. Received fresh labeled and "inter aortic lymph nodes" is a matted mass of apparent lymph nodes replaced by tumor, 7.5 x 4 x 2.5 cm. Sampled in three cassettes labeled G. Received fresh labeled and "left common iliac lymph node number 2" are two irregular portions of apparent tumor-replaced lymph node tissue, 2.5 x 1.5 1.2 cm, and 3.5 x 2 x 1.5 cm. Sampled in two cassettes labeled Support for the diagnosis in this case may have included the use of immunohistochemistry tests that were developed and whose performance characteristics were determined by They have not been cleared or approved by the U.S. Food and Drug Administration (FdA).
+
+--- Page 8 ---
+Page 8 of 8 The FDA has determined that such clearance or approval is not or for research. This laboratory is certified under the Clinical to perform high complexity clinical laboratory testing.. 99[3
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diff --git a/output/text/b3ba2f4b-324e-4b11-bd97-91573faeabbb.txt b/output/text/b3ba2f4b-324e-4b11-bd97-91573faeabbb.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6b7bb4eb5826e7fb5c9b60ebe5ffb581b0351b47
--- /dev/null
+++ b/output/text/b3ba2f4b-324e-4b11-bd97-91573faeabbb.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis Right hemicolectomy preparation with a cecal carcinoma histologically characterized as a moderately differentiated colorectal adenocarcinoma, almost completely covering the cecum, and measuring 5.5cm in diameter at the widest point. Invasive spreading of the tumor within all intestinal walls up to the bordering fatty tissue and the subserosa. Oral and aboral resection margins are tumor-free as is the greater omentum.. 21 mesocolic and mesenteric lymph nodes are tumor-free with uncharacteristically. reactive lesions. Therefore the tumor stage is: pT3, pN0 (0/21) L0, V0; G2.
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diff --git a/output/text/b3d75023-8e8a-4374-9c0a-7a112f28b850.txt b/output/text/b3d75023-8e8a-4374-9c0a-7a112f28b850.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f6232c3017fa4e0b37bc568cb2ec5f462c589992
--- /dev/null
+++ b/output/text/b3d75023-8e8a-4374-9c0a-7a112f28b850.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+/c-0-3 C 50.y Sifr : brast Nos h 1o/3/11 UUID:57359A9F-7E5A-4599-918C-A95DCF0D9479 TCGA-BH-AORX-01A-PR Redacted FINAL DIAGNOSIS: Part 1: breast, Left, segmental. master;TOmy - A.  iNVASIVE DUCTAL CAFCINOMIA, 4.2 CM (GROSS), NOTTINGHAM GRADE 3 (COMBINED NOTTINGHAM SCORE Q/9: TUBULE FORMATION 3/3, NUCLEAR ATYPIA 3/3, MITOTIC ACTIVITY 3/3), WITH COMEDONECROSIS AND ASSOCiATED MICROCALCIFICATIONS AND LYMPHOPLASMACYTIC INFILTRATE. DEFINITIVE IN STU CARCINOM A H +O: (CENUFRED) C. iARGINS FREE, CLOSEST POSTERIOR WITHIN 0.1 CM, SECOND CLOSEST SUPERIOR WITHIN O.2 CM. . LYMPHOYASCULAR INVASION IS NOT IDENTIFIED. E ATYPICAL DUCTAL FPITHELIAL HYPERPLASIA. F. FLAT EPITHELIAL ATYPIA. G. FORID DUCTAL EPITHELIAL HYPERP ASIA. H. COLUMNAR CELL CHANGES IN HYPERPLASIA. ADENOSIS A.ND3>.LFOSNG AINS3. . .J. 12RDA LE N M ATOID CHANGES AND FIBROADENOMATA K. B'ofsy s'e chanoss 1.. PATYOLOG'C STAGE (SAE COrTnGT) PaRT 2: BrEaST, LSFT, NEW SUPSRIORALATERAL MARGIN - TREdOMIYANTLy ADIPOSE DOEAS T TI YTYYIYIS, IHSATIVe FOr TUmOR. PART 3: SEHTNT. LYETPH NGDE *1. LEFT AXLIA, OOPSY - ONE LYMPY NOIE. NEGATIVE FOR AIETASTATIC CARCINOMA. .. RARE fOC! gF GIANT CSILS IN SUSCAPSULAR SPACE, CONSISTENT WITH PRIOR INTeRVeNTION. ?. TXI LAFY SCF~ TISSUE yUTH FAT MI CTO SIS, INFLAMmATIOn AND FIBROSIS, CONSISTENT WITH PRIOR WTERVTNTION. PART a: Ss: 7.MTT .YMTH WoET #E, LEFT AXLLA. BOPSY. ONE I TTSPH NOCE: NEC STIVE FOR MSTASTATIC CARCINOMA (O/1) Part 5: SeNTInEl Lymp4 NODe *?, LEfT AXILIa. BIOPSy - CNT I YNPH HOEY. "EA STIYE rOP MRTASTATIC C ARCINOMA (O/1).
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diff --git a/output/text/b3e23fda-f481-434a-8ec5-bdb5e0bab219.txt b/output/text/b3e23fda-f481-434a-8ec5-bdb5e0bab219.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9f1ae8748e0f26598e3ab621d0ec6dcdf5c2b922
--- /dev/null
+++ b/output/text/b3e23fda-f481-434a-8ec5-bdb5e0bab219.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:DCDEE014-3447-4DA3-A14F-48C6AED05302 TCGA-BH-A0W7-01A-PR Redacted PATIENT HISTORy: Not provided. LMP: Not provided. PRE-OP DIAGNOSIS: Left breast carcinoma. POST-OP DIAGNOSIS: Same. PROCEDURE: Leit segmental mastectomy needle localization, sentinel node biopsy leu axma. COMMENT: Foci of malignant clusters and glands surrounded by retraction type spaces are Identified, and art stained for endotheial markers (D2-40 and CD31) for a more definitive interpretation. The resuits wil! be reported in an addendum. ER, PR and Her-2/Neu were performed on the core biopsy : 3 and are reported as positive for receptors and negative for Her-2/Neu. Pathologic stage: T1c N0 MX. ADDENDA: Addendum Immunostain tor endothellal markers (iymphatlc and vascuiar) highllght the endothelia! celis and conflrms the absence of lymphovascular space involvement by tumor. MICROSCOPIC: Utilizing formalin-fixed (8-96 hour range). paraffin embedded tissue, immunohistology is performed with the foliowing selected antibodies and designated antibody clone(s), directed against the tollowing antigenic target(s), with adequate positive and negative internai and external controls. Antibodies are optimized appropriate for fixation times.. Utilizing  formalin-fixed (8-96 hour range). paraffin embedded tissue, immunohistology is performed with the foliowing selected antibodies and designated antibody clone(s). directed. against the following antigenic target(s!, with adequate positive and negative internal and. external controls. Antibodies are optimized appropriate for fixation times. ANTIBODY CLONE TARGET ANTIGEN VENDOR D2-40 D2-40 Lymphatic Endothelium CD 31 Dako JC70A endothelium Dako EE/shm The totlowing statement applies to al Immunohistochemistry, insitu hybridizatlon (ISH & FisH), molacular anatomkc pathology, and immunofluorescence testing: Tne testing was developed and its pertormance characterlstics determined by the required by the CliA 's8 regulations. The testing has not been cleared or approvea ior ine specimic use oy tno u.s. Food and Drug Administration, but the FDA has determined such approval Is nat necessary tor clinical use.. complexity clinical testing. Pursuant to the requiremanta ot CLia, AsR'a used in this iaboratory have been establlshed and verified for accuracy and preclslon. Addltional inlormation about this type of test is avallable upon request.. CASE SYNOPSIS:  SynOpTiC - PRImARy InVasIvE CARcINQmA OF bReASt Laterality: procedure: (Let  Segmental LOCATION: Upper inner quadrant SizE Of tumor:  Maximum dimension invasive component: 1.6 cm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: Yes TumOR aGgREgATE SiZE: Sum of the sizes of multiple invasive tumors: 1.9 cm TumoR Type (Invasive component): Ductal adenocarcinoma, NOS nOTTingHAM SCORE: Nuclear grade: 2 Tubule formation: 2 /cs-0-3 Mitotic activity score: 1 Total Nottingham score: 5 Nottingham grade (1, 2, 3): 1 cicnioma, infiltratng cluct, nCK ANgIOLymphATIc INVASION: DeRmal Lymphatic invasiOn: No 8.500/3 Not applicable CALCIFICATION: Yes, benign zones SURgICAL MARGINS INVOLVED By inVASIVE COMpONENT: Site: briot, Nos csv.9 SURg MARGINs InVOLVED By In SITU COMPONEnT: No No Lymph nodes positive: Lymph nodes examined: 0 10jis/1 mEthOD(S) Of Lymph nODE EXAminATiON: 2 H/E stain t stage, pathologic: pT1c N stage, pathologic: pN0 m stage, pathologic: pMX Estrogen RECEptOrS:  previously performed  PROgESTERONE RECEPTORS: previously performed HER2/NEU: zero or 1+
+
+--- Page 2 ---
+FINAL DIAGNOSIS: PART 1: BREAST,LEFT, 10 O'CLOCK, NEEDLE LOCALIZED SEGmENTAL MASTECTOMY - A.  INVASIVE DUCTAL CARCINOMA, TWO FOCI, 1.6 CM (GROSS) AND 0.3 CM (MICROSCOPIC), NOTTINGHAM GRADE 1 (COMBINED NOTTINGHAM SCORE 5/9: TUBULE FORMATION -2/3, NUCLEAR GRADE- 2/3, MITOTIC ACTIVITY- 1/3) WITH LOBULAR FEATURES. B. DUCTAL CARCINOMA IN SITU IS NOT IDENTIFIED. C. MARGINS FREE, CLOSEST ANTERIOR WITHIN 0.2 CM FROM THE LARGEST TUMOR FOCUS, SECOND CLOSEST LATERAL WITHIN 0.5 CM FROM THE SMALLER TUMOR FOCUS. D. LYMPHOVASCULAR INVASION (SEE COMMENT). E. ATYPICAL DUCTAL EPITHELIAL HYPERPLASIA. F. DUCTAL EPITHELIAL HYPERPLASIA. G. COLUMNAR CELL CHANGES AND HYPERPLASIA WITH ASSOCIATED MICROCALCIFICATIONS H.  FIBROADENOMATOID CHANGES. PSEUDOANGIOMATOUS STROMAL HYPERPLASIA (PASH). !. J.  CAPILLARY HEMANGIOMA. -- K. CAUTERY ARTIFACT. BIOPSY SITE CHANGES. M.  PATHOLOGIC STAGE (see comment). PARt 2: NeW LATEraL mArgIN, EXCISiON - A.  NEGATIVE FOR TUMOR.  FIBROADENOMATOID CHANGES. C. FIBROCYSTIC CHANGES. D. COLUMNAR CELL CHANGES. E. DUCTAL EPITHELIAL HYPERPLASIA, MILD. F. ADENOSIS. G.  PSEUDOANGIOMATOUS STROMAL HYPERPLASIA (PASH). CAUTERY ARTIFACT. PART 3: SENTiNEL LYMPH NODE #1, LEFT AXILLA, BIOPSY - ONE LYMPH NODE, NEGATIVE FOR METASTATIC CARCINOMA (0/1). PArt 4: SEnTinel Lymph nODe #2, Left AXilLA, BiOpSy - ONE LYMPH NODE, NEGATIVE FOR METASTATIC CARCINOMA (0/1). COMmENT: Foci of malignant clusters and glands surrounded by retraction type spaces are identified, and are stained for endothelial. ER, PR and Her-2/Neu were performed on the core biopsy! ! and are reported as positive for receptors and negative for Her-2/Neu. Patholoaic stage: T1c N0 MX. Addendum Immunostain for endothelial markers (lymphatic and vascular) highlight the endothelial cells and confirms the absence of Iymphovascular space involvement by tumor.
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diff --git a/output/text/b4053a92-9cd5-4081-b62f-7b8f864e04b9.txt b/output/text/b4053a92-9cd5-4081-b62f-7b8f864e04b9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fa7161feb26b922954c6181bb17f24ef53b52bb1
--- /dev/null
+++ b/output/text/b4053a92-9cd5-4081-b62f-7b8f864e04b9.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+1es-0-3 Carcn rma, mfilrratmg ouctol Nos 85oo/3 1/28/ Sih:breast nos C50.9 D#: Pathology Form Specimen Information Collected by: Preserved by: Date  SPECIMENTYPE(#of samplesprovided)M Frozen Paraffin Block Blood/Serum/Plasma Slide Diseased  Normal Diseased Normal Diseased Normal Diseased Normal 2 2 Time to LN2 Time to Formalin Time to LN2 73 min min min SRCIEASPANRATHOLOGICAEDESCRIPTIONIEESAMSESEA Primary Tumor Organ Size Extension of Tumor Distance to NAT BregcT Venor  x 3x 2cm 6 cm Lymph Nodes Location # Examined # Metastasized Distant Metastasis Organ Detailed Location Size Pathological Staging pT z. N 1 M O Stage: Notes:  pv8iZive B3Reast node8 3  >NeG=l've 2 1ReaST AxbS(2 Licef in N;Froge7 2 slide) UUID:7045ECC9-72B3-4AD3-A6C6-4F8C6914EAA1 TCGA-C8-A135-01A-PR Redacted
+
+--- Page 2 ---
+D#: Microscopic Description eaaHistologicalPatern.e Cell Distribution Structural Pattern + Diffuse Streaming  Mosaic  Storiform  Necrosis Fibrosis  Lymphocytic Infiltration  Palisading Vascular Invasion Cystic Degeneration Clusterized  Bleeding  Alveolar Formation  Myxoid Change Indian File Psammoma/Calcification orn.CellularDiffrentiationwaa Squamous Adenomatous +  Sarcomatous + Lymphomatous[+ Squamoid Cell Glandular cell  Round Cell  Large Cell Spindle Cell Cell Stratification Fibroblast Small Cell  Keratin  Secretion Osteoblast RS Cell/RS Like Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell Pear! Gland formation  Myoblast  Plasma Cell Cellular Differentiation: Well Moderate  Poor NuclearAppearancea Nuclear Atypia: 0 I II III  Aniso Nucleosis Hyperchromatism Nucleolar Prominent  Multinucleated Giant Cell Mitotic Activity Nuclear Grade: Marker Result Value Date ER  Negative  Positive PR  Negative  Positive Her-2/neu  Negative  Positive B-Cell Marker  Negative  Positive T-Cell Marker  Negative  Positive Other:  Negative  Positive Other:  Negative  Positive Final Pathology Report Histological Diagnosis: Grade:I7 Comments: Pathologist Date 5
+
+--- Page 3 ---
+CONsOlIdateD DIAgNOstIc pathOLOgy fOrm* Microscopic Appearance: Histological pattern:  CELL DISTRIBUTION Diffuse STRUCTURAL PATTERN Mosaic A  Streaming Necrosis  Storiform Lymphocytic Infiltration Fibrosis Vascular Invasion  Palisading X Cystic Degencration Clusterized Alveolar Formation x Bleeding. Myxoid Change Indian File x  Psammoma/Caicification 2. Cellular features. Squamous + Adenomatous  Squamoid Cell Sarcomatous Glandular cell Lymphomatous Round Cell Spindle Cell Large Cell Cell Stratification Fibroblast Keratin Small Cell  Secretion Osteoblast RS CelV/RS Like Desmosome Intracyt. Vacuole Lipoblast Inflam. Cell  Pear!  Gland formation Myoblast Otheswise Specified:  Plasma Cell D, 70% D 7ZoDz 70% D480% nee 2. Cellular Differentiation: Well Moderately Poo X 3.Nuclear Atypia: Nuclear Appearance Aniso Nucleosis Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity Nuckear Grade Histological Diagnosis: Tnpltass >uutaL Caninmyy ,Nds, O-3 : Careintos Netastosied to1Ue Comments:M ,Ms2 Date ) PATHOLOGIST STAFF FOR RESEARCH USE ONLY). NTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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diff --git a/output/text/b44d888f-e9ba-4368-bd2b-6ecb87342501.txt b/output/text/b44d888f-e9ba-4368-bd2b-6ecb87342501.txt
new file mode 100644
index 0000000000000000000000000000000000000000..464533f1e7261973aaf6375b2ec67a63e11c4d2a
--- /dev/null
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+PATH LOCIC DIAGNOSIS: APT RADNEY: RENAL cRh.CArCINOMA.chxomgpiOberype.6.9cm. The tumox ic ront ined to the kidney. Fuhman grade Ilot Iv. varcuar, ureier and sofl ticsue mnrglns are negatiye fcr cumor. No Lympnovauelar invaxion identisied. A6tn di.onT1b Nx MX. repr cted aa an acdr. CLI ICAL DATA: Mis ry None give. Opeation: Laparosropi lett rodica nepnrectomy Qpc acive Findjng None given. iical piagnosis: Lft renal mags. TIS:UE SUMITTED: A/1 Lefr kidncy. ORO.ORSCRIPTION The specimen t received frenhlabelcd with the pocicnt name,unit numbex,  .Let kidcey.and consios 506 gn.23.0x 12.8 6.0 cn let wt.6.xa.0 x1. n let adreno gland.attacned avzrounding adipose in uc end a Js.r.s cm patch ot Cerota fascia ic present, and nan been inkk.e.Hi.i rcgin exhibite.cmurctericiameter.4 cm1. en rtry ameter 1.5 mand 1.3 cm renul vein maximum diameter i.6 cm. The ptme hos been sntirely inked and bivulved, revealing a sircumsczihed, pr icy encapsuleted can/pink to tan/ynliow (6. x.7x 2.s cm abutting and Diok ked mrgi cnd abteing te cenal pelvis. Mas is J0.u cm trom tle ure era.maxgin.0 cm co tharrerial murgin.and 3.a cm from the renal vein marin. Macs demns.rare centra focel necrosi(2st of surfaces.and Lo ralciyutin l.5 cm. and ncant hemorrhage located within the upper pole. Note: Tisne allocation for spccimen states closest black inked margin as vithn 3.2 cm upon turther coctioniny of she rumor clcsest black inked m gin s within .5 cm. This tiue is freely.nobila over the underlying exande renal canic. Remaining renal. parenchyma is grossly unremarkabie, w dstinct cor icnl medilary jonction and no additiona lesions grossly rthej ium is likwe unremarkabic. Adranal glan is grorsly uninvolved by r.and is recivd diorupted h is ccherwise wnremakeble quetonahly or ple. Renresencative rimcr has keen nent for EM, cytogenetico and tiasue buk. Pepresentav normal renal parenchyma and adrenal gland have sbmicr.ed ro igaue bank. Represenlativn norma. rena paxenchyma (cortex lac been sumitced for E and F. Mi.2o  Vasclax, ureteral margin.3 frags. M.rn A2 Tinoue in cascetre cesignated rri Mi ro A3 Tmor rsnal cansule closeot hlack inked margin 3 frags, trag Mi r4 Tumor and surroanding ninvolved renal parenchyna,a fxage ML ro A Foeally eleified tumor tiollowing decal),I frog, Mi r6 Uninvived ronal paronchyma uninvoived adrenal gland  trags, RSS. PageI of2
+
+--- Page 2 ---
+p.rsonally condute a microncopic cxamination gronn only exam if so stated riat thercco. PTHOLOGIC DIAGNOSIS EALUATXON OF TH: KIDNEY PARENCHYMA NOT ANVOLYED DY TUMOR: NEPHRECTOMY SPECMEN FXDNEY PARENCHYMA WETHOUT SXCNTFICANT PATHOLONTCAL CHANGES (SEE NOTE) ARTERIA ANLAFTEKICLAR SCIEROHISWITH SUBINTIMAI HYALINOSIS. MILD TO MODERATESRRNOTE NC The kidney rarenchyma of this nephrectomy specimen does not reveal Mimificant chance on the glomeruli or of the cubulointexstitial comparcment; th re i no cvidonce tor an ative glomeruiar inlamnatory process or tu ulointrstitia injury. The biopsy shows only mild ca mderate chronic va .culnr injury. MI RCSCOPIC DESCRIPTIOH he mampic consigrs of kidney cortes and medule. There re up ce On nondxed (loo) giomeruli presene in the cample submicteri tox ligh mi roscopy. Glomennii with glcbal sclerosis arn not recognced. The gicmeruli sh.w a preserved arcaitccture. wth pranetvation of the mcrangial mrrix and ce llar element. Tnere is no evidence ot active collulr prolfercicn ox in lannntion. On PAs and Jones  silvor methcramine stain.rhe glonerular ba.ement membrane appear deijcate. wihout sianificant irroguiariticn. No do ble oncours c pikelike lesion re recogrized. vauolization win moderae amount o hyaline cats in che disraj tbuleo. Tbules revea mil Thre is mild sybla atrophy. Les than st ot te canple chows tubuinr acrophy and interntitial tibrosis as The incarotitiun raveals also mild ibrnsis. ev:deced on the richrome tains Aro Aterent end afcel. arteriols show miid scierosis an hyalin Axrariec reveal. moderate intimal th vecsei wal
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diff --git a/output/text/b458bb6e-9898-492d-9275-eb4d87324a67.txt b/output/text/b458bb6e-9898-492d-9275-eb4d87324a67.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e1f54c3ef31bdd156f3b8f50a793f20ed63b5fa2
--- /dev/null
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+
+--- Page 1 ---
+Patient Key: Surgical date: TISSUE DESCRIPTION: Liver segments IV through VIII (1,900 grams; 22 x 14 x 9 cm), liver segment III (15 grams; 4.5 x 3 x 2.7 cm), and biopsy specimen from the peritoneum (1 x 0.8 x 0.4 cm). A1, B1, B2, B3, B4, C1 DIAGNOSIS: Liver, segments IV through Vill, resection: Grade 2 (of 4) hepatocellular carcinoma, usual type, forming a multinodular mass, 16 x 15 x 11 cm, with multiple (5) satellite nodules ranging in size from 0.5 cm to 1.5 cm. The tumor is located in segments IV through Vill. The hepatic capsule is free of tumor. The surgical margins are free of tumor, the clearance being approximately 1 mm microscopically. Extensive extratumoral vascular invasion is identified. The tumor is not encapsulated, infiltration of parenchyma being of the infiltrating type. The non- neoplastic liver will be assessed on permanent sections and an addendum will be issued. Liver, segment Ill, excision: Bile duct hamartoma (1.2 x 1.1 x 1 cm).. Peritoneum, biopsy: Inflammatory adhesion, negative for tumor.. Specimen photographed in lab.. PHOTOGRAPHED IN LAB ADDENDUM: The non-neoplastic liver shows no features of either primary or chronic liver disease. Seen with Dr. 1cs-0-3 hepnfocludu,Nvs 8170/3 Cariinm lw Site. lww Cs3.0 9/2/ UUID:EAB38F5C-4399-48DE-A4F5-18B7CB982689 CGA-DD-A3A1-01A-PR Redacted
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diff --git a/output/text/b46452a0-d1c5-4d00-960e-0320b4c72122.txt b/output/text/b46452a0-d1c5-4d00-960e-0320b4c72122.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3edccb64bbec746a0be8c3d4b48faa4794c831b4
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+
+--- Page 1 ---
+UUID:AA3CF932-9666-4280-9F3E-5CFA523CEC4B TCGA-5M-AAT5-01A-PR Redacted Date: SPECIMEN: sigmoid colon PROCEDURE: rectosigmoidectomy MACROSCOPY - Segment of colon, measuring 17.0 cm in length and 3.0 in diameter. - Vegetative lesion, with elevated borders, measuring 5.0 x 4.5 cm, located in the mucosa 1.8 cm from the nearest surgical margin.. - The lesion penetrates the full thickness of the wall, infiltrating the adjacent fat tissue. - Two separated fragments of unlabeled colonic mucosa: one circular measuring 2.3 cm in diameter and 0.7 cm in length, the other irregular, measuring 1.5 x 0.9 x 0.4 cm. - A number of lymph nodes dissected from the adjacent fat tissue. MICROSCOPIC EXAMINATION - Moderately differentiated, invasive, tubular adenocarcinoma of the sigmoid colon; - Microscopic tumor extension: tumor penetrates the full thickness of the colonic wall, extending. to the pericolic fat;. - Perineural invasion: present; - Surgical margins free of neoplastic involvement; - Circular fragment consisting of colonic wall, which displays no signs of neoplastic involvement; - Irregular fragment consisting of fragment of adenocarcinoma; - Number of lymph nodes examined: 13; - Number of lymph nodes involved: 04; ID O 3 - Stage (TNM): pT3 pN2 ME ldenarcuron NoS 814oJ3 PATHOLOGISTS ClolendCareirtmr;tulular 8211/3 Site: Sigmsiol clors C 18:7 X) sf21/14 h s//14
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diff --git a/output/text/b48b7d33-5537-427c-8b71-e33c261e89ff.txt b/output/text/b48b7d33-5537-427c-8b71-e33c261e89ff.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b48bf00f508aa19dc579acc66c2901a938dfd54b
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+
+--- Page 1 ---
+/C.0-0-3 Cantinoma,infiltratiry ductal, Nos 85os/3 Sit: hreot, Nos C50.9 Diagnosis: 1. Ablated breast sample with a moderately differentiated invasive ductal carcinoma. (tumor diameter 105 cm) with focal ulceration of the skin and a satellite node (diameter 0.9 cm) in the skin. Tumor-free dorsal resection margin.. Together with the preliminary finding, this gives rise to the following tumor classification: NOS, G II, pT4b pN3a(11/22)L0V0R0. UUID: 34499A83-DFCE-4D88-BAA0-A7590AF8BC07 TCGA-A8-A099-01A-PR Redacted
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diff --git a/output/text/b5055e03-defc-4b36-a000-91ee69cba1a5.txt b/output/text/b5055e03-defc-4b36-a000-91ee69cba1a5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..652d9d3ac5cb6d58523519452597ae3726ad9a67
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+
+--- Page 1 ---
+TCD-o-3 UUID: 68F5B84D-8967-4A77-B5D9-65526AB9FF BB Redacted C0rcnoro, adw^euaI cer HcoI 83703 Site AdreaI Cland cortex. Procedure: adrenalectomy C 74.d Gross description: 8 x 7 x 7cm, 212g .2 Reference Pathology only:. Diagnosis: adrenocortical carcinoma, Kl67 1%; final diagnosis adrenocortical carcinoma, initial diagnosis adenoma, mitotic rate <1 per 10 hpf Weiss score: 5 Hough score: 3.37 Van Slooten score: 17.8
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diff --git a/output/text/b52f7caf-eb78-4345-89b8-2728225e3870.txt b/output/text/b52f7caf-eb78-4345-89b8-2728225e3870.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d340002f9295a4617ee2fa5319de34ad2532f645
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+
+--- Page 1 ---
+IDO3 UUID:B7674358-B4F0-4348-954A BD9C076 TCGA-GS-A9TX-01A-PR Redacted Zy,nphovra.., ciflie. Lauge Beill ll 968c>13 C774 LEFT INGUINAL LYMPH NODE: y J 3/3i/4 Nodular fragment of 4,5 x 4 x 2,5 cm. LEft INguinAl Lymph nOdE, EXciSiON: - DIFFUSE LARGE B-CELL LIMPHOMA Sections show the presence of a diffuse large cell lymphoma with. centroblastic morphology, admixed with several accompanying small cells. A minimum area with several lymphoid follicles of a reactive aspect is recognized, some of them probably secondary colonized by the neoplasia The tumour population is positive for CD20, CD79a CD10, BCL6, and CD23, and is negative for CD3, CD5, BCL2, CD21 and p53. A Lambda light chain restriction is observed. There are abundant reactive T-cells positive for CD3 and CD5. The Ki-67 proliferation index is 75%.. FISH study has shown that the atypica! population does not show rearrangements of the BCL2 gene, it presents gains of the BCL-6 gen and Iosses of the chromosome 1 (region 1p36). 4211312213
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diff --git a/output/text/b535c84d-c9f1-4db2-a204-6219c2f5a81b.txt b/output/text/b535c84d-c9f1-4db2-a204-6219c2f5a81b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8ba154f654242b204862c7c550b8f4d8fcc290c8
--- /dev/null
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+--- Page 1 ---
+1cd-u-3 Curcin min,nifiItratMg guct, nos 85oq|3 PATIENT HISTORY: * nnDATE of LMP:  Site Cde. breast loww ninr quodrnt DATE OF LAST DELIVERY: * PRE-OP DIAGNOSIS: LEFT BREAST CA c 50.3 POST-OP DIAGNOSIS: SAME OPERATIVE PROCEDURE: LEFT MOD. RADICAL MASTECTOMY, TRAM CLINICAL HISTORY: MATERIAL SUEMITTED: LEFT (MOD) RADICAL MASTECTOMY, PROCUREMENT BY SURGICAL PROCEDURE & axillary contents INTRAOPERATIVE CONSULTATION: Skin: 6.0 by 4.5 cm. Overall breast: 17.0 by 24.0 by 5.0 cm. Tumor mass: 2.5 by 2.0 by 3.5 cm. Close to anterior margin. Possible tumor approximately 1.0 cm close to inferior margin.. ADDENDA: Addendum HER-2/neU AMPLIFICATION ANALYSIS (FISH) AS PER THE REQUEST OF FLUORESCENCE IN SITU HYBRIDIZATION'(FISH) WAS PERFORMED ON SURGICAL CANCER) USING THE VYSIS DNA PROBE FOR THE HER-2/neU GENE (BREAST CHROMOSOME 17 CENTRCMERE SIGNALS WAS DETERMINED TO BE 2.O5. A RATIO OF 2.0 OR GREATER IS CONSIDERED THE RATIO OF HER-2/neU SIGNALS TO AMPLIFTED; THEREFORE, THIS SPECIMEN IS AMPLIFIED. Addendum MATZRIAL SUBMITTED: BLOCK ~A2" FOR ER/PR AND HER-2/NEU (BREAST CANCER) FINAL DIAGNOSIS: ESTROGEN/PROGESTERONE RECEPTORS AND HER-2/NEU PERFORMED CN LEFT BREAST TISSUE ESTROGEN RECEPTOR (0- 203; 1+ 303; 2+ 30%; 3+ 20t) HSCORE OF 150. sSTROGEN RECEPTOR I3 INTERPRETED AS POSITIVE PROGESTERONE RECEPTOR (0- 10; 1+ 10t; 2+ 20t; 3+ 6Ot) HSCORE OF 230. PROGESTERONE RECEPTOR IS INTERPRETED AS POSITIVE HSCORE: <= 15 NEGATIVE > 15 <= 30 BORDERLINS > 30 POSITIVE HER-2/NEU - DAKO HERCEPTEST: A WEAK TO MODERATE COMPLETE MAMBRANE STAINING IS OBSERVED IN MORE THAN 1O% OF THE TUMOR CELLS. HER-2/NEU IS INTERPRETED AS WZAKLY POSITIVE (SCORE 2+). NOTE: Hor-2/Neu FIsH was ordered. The Her-2/neu and estrogen assays were performed with FDA approved methods. The progesterone receptor immunoperoxidase test used in this case has haan davalonad Any the performance characteristics determined by the Department of Pathology at  They have not bean cleared or approvod by the U.s. Food and Drug Administration. Hscore'is modified from: Estrogen Receptor Analysis, Arch Pathol Lab Med 1985; 109:716-721. My signature is attestation that I have personally roviowed tho submittod material(s) and the final diagnosis reflects that evaluation. FINAL DIAGNOSIS: FINAt. DIaGNOSIS: LEFT BREAST AND AXILLARY CONTENTS CM, NOTTINGHAM SCORE 6/9 (TUBULES 3, NUCLEI 2, MITOSIS 1) WITH DUCTAL CARCINOMA IN-SITU, NON-COMEDO WITH CENTRAL NECROSIS AND CRIBRIFORM TYPE DUCTAL CARCINOMA IN-SITU REPRESENT APPROXIMATELY 2O OF THE TUMOR VOLUME FIBROCYSTIC CHANGESS TWO (2) SEPARATE NODULE OF INEILTRATING DUCTAL CARCINOMA ARE PRESENT IN THE LOWER INNER QUADRANT, O.8 CM/. AND UPPER INNER QUADRANT, 0.5CM - TUMOR IN THE LOWER INNER QUADRANT IS WITHIN 1.O MM FROM THE MARGIN OF RESECTION - ALL MARGINS OF RESECTION ARE FREE OF TUMOR FOUR OF SIX (4/6) LYMPH NODES AR3 POSITIVE FOR METASTATIC TUMOR TWO (2) LYMPH NODES SHOW EXTRACAPSULAR SPREAD  THREE (3) SMALL FIRM NODULES SIMULATING LYMPH NODES IN THE AXILIARY CONTENTS SHON INFILTRATING DUCTAL CARCINOMA NOTE: ER/PR immunoperoxidase y and Her-2/Neu testing will be performed on block "A2". UUID:4F67B78E-68C1-40E1-8276-2D26B46C744D TCGA-BH-A18M-01A-PR 'Redacted
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diff --git a/output/text/b5545c03-f639-4920-9b98-5c2e04e38ca7.txt b/output/text/b5545c03-f639-4920-9b98-5c2e04e38ca7.txt
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index 0000000000000000000000000000000000000000..e921318c331141a4fd23222a3c0ec6660713676e
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+
+--- Page 1 ---
+UUID: 226031B3-D9C2-4343-B3F7-4E0C368901E7 TCGA-AR-A24T-01A-PR Redacted Final Diagnosis Breast, right, simple mastectomy: Infiltrating lobular carcinoma, Nottingham grade I (of IIl) [tubules 3/3, nuclei 1/3, mitoses 1/3; Nottingham score 5/9], forming a mass (5.7 x 4.8'x 2.1 cm) located in the mid outer quadrant of the breast [AJCC pT3]. Lobular. carcinoma in situ is identified. Angiolymphatic invasion is present. The non-neoplastic breast parenchyma is unremarkable. Biopsy site changes are present. The tumor does not involve the nipple, overlying skin, or underlying chest wall. All surgical. resection margins, including the deep margin, are negative for tumor (minimum tumor free margin, 0.3 cm, deep margin).. Lymph node, right axillary sentinel, excision: A single (1 of 1) right axillary sentinel lymph node is positive for metastatic. carcinoma. Extranodal extension is not present. Blue dye is identified. Lymph nodes, right axillary, dissection: Multiple (14 of 16) axillary lymph nodes are positive for metastatic carcinoma [AJCC pN3]. Breast, left, simple mastectomy: Proliferative fibrocystic disease without atypia characterized by ductal hyperplasia, usual type,. sclerosing adenosis, parenchymal fibrosis, and cyst formation. Her-2/NEU has been ordered on paraffin-embedded tissue. 1cs-0-3 carcmono, mfiltrst,sg 1obulxv Nos 8520f3 Sin: brut Nos C50.9 hw 4/3s/n
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diff --git a/output/text/b5676c96-49d5-4329-8bc2-3284fc033592.txt b/output/text/b5676c96-49d5-4329-8bc2-3284fc033592.txt
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index 0000000000000000000000000000000000000000..fb0508201214690d4e4f0080f0c101ad0132a503
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+--- Page 1 ---
+Department of Cancer Pathology (cito) Date Examination: Histopathological examination. rutpre organ resection -- segment of the large intestine. TCGA-D5-5538 Material collected on: Material received on: Clinical diagnosis: Cancer of the cecum. Examination performed on Macroscopic description: 25.3 cm length of the large intestine with perintestinal fat tissue sized 24 x 9 x 2 cm, with a 5 cm length of. the small intestine, and a 5.5 cm appendix. Ulcerous tumour sized 4.2 x 4.1 x 0.6 cm found in the mucosa. The lesion surrounding 100% of the intestine crcumference, 5 cm from the proximal cut end, 17 cm from the distal cut end, and 1.2 cm from the ileocecal valve. Blue dye injected.. Microscopic description: Adenocarcinoma tubulopapillare (G2). Infiltratlo carcinomatosa valvulae Baughini et parietis ilei et telae adiposae pericolicae. Incision lines free of neoplastic lesions. Metastases carcinomatosae in lymphonodis (No IIl/Vi. Inflltratio carcinomatosa telae adiposae perinodalis. Other lesions of the tumour resident type. Histopathological diagnosis: (including examination No. Adenocarcinoma tubulopapillare coli. Metastases carcinomatosae in lymphonodis (No Ill/vI). (G2, Dukes C, Astler-Coller C2, pT3, pN1) MEA5ATKh(mP6 kOrS CM/VIJ
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diff --git a/output/text/b5b07d7e-0058-471d-a729-f6390a2d4813.txt b/output/text/b5b07d7e-0058-471d-a729-f6390a2d4813.txt
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index 0000000000000000000000000000000000000000..cdd298f0bab548389638ff284fe85b9d69748dc0
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+--- Page 1 ---
+Diagnosis/ diagnoses Resected section of colon (sigma) with an ulcerated colon carcinoma histologically. characterized as a poorly differentiated colorectal adenocarcinoma, extending within. 0.5 cm of one resection margin, almost completely encircling the intestinal wall and. measuring a max of 3 cm in diameter. Invasive tumor spread within all intestinal wal Iayers as far as the periproctic fatty tissue layer. Lymphangial branches in the tumor. margin area. Oral and aboral resection margins are tumor-free. Four out of 24 mesocolic lymph nodes with extensive metastases of the colon carcinoma. partly transgressing the lymph node capsules. The remaining lymph nodes have. uncharacteristically reactive lesions. Therefore the tumor stage is: pT3, pN2 (4/24) L1, V0; G3
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diff --git a/output/text/b5b104a5-319d-4650-a587-d6c01d419fdb.txt b/output/text/b5b104a5-319d-4650-a587-d6c01d419fdb.txt
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index 0000000000000000000000000000000000000000..36b9ef854a6139e338694f0518f2d2eb23301f17
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1e-0-3 Csscnomn, mfiltnut'wg duct,nos 85os/3 c50.q She: Busst, Nos 1/2/ Procedure Date: Procedure Physician: Attending Physician/Copies To: UUID:16DEA43F-4A61-44E3-854F-686575B45628 TCGA-BH-A1EV-01A-PR Redacted Patient history: *'nnDaTE of LMp: * DATE OF LAST DELIVERY: * PRE-OP DIAGNOSIS: L BREAST CA. POST-OP DIAGNOSIS: SAME OPERATIVE PROCEDURE: L NOD RAD NAST CLINICAL HISTORY: MATERIAL SUEMITTED: RIGHT (MOD) RADICAL MASTECTOMY, PROCUREMENT BY SURGICAL PROCEDURE INTRAOPERATIVE CONSULTATION: COnsulr: Left breast tissue: Breast tissue with nipple/areola complex: Multilobed, diffuse breast mass with. multifocal,  Individual firm secondary masses, malignant. Total dimension to be determined with gross. ADDENDA: Addendum FINAL DIAGNOSIS: ER/PR IMMUNOPEROXIDASE IDENTIFICATION OF KSTROCEN AND PROGESTERONE RECEPTORS IS CARRIED CUT ON SLIDE "A2". DISTINCT INTRANUCLEAR STAINING IS IDENTIFIED FOR ESTROCN RECEPTOR (9Ot) AND PROGESTERONE RECEPTOR (40t) . THEREFORE, BOTH ARE INTERDRETED AS POSITIVE. HER-2/NEU C-OrbB2 (HER-2/NEU) DMOSUNOSTAINING IS CARRIED OUT ON SURGICAL S BLOCK "A2" (BREAST CANCER) USING A 1:30O DILUTION OF DARO'S POLYCLONAL ANTIBODY A48S (DIRECTED AGAINST THE INTRACELLULAR DOKAIN OF c-OrbB2) WITHOUT ANTIGEN RETRIEVAL. DISTINCT COKPLETE MDQRANE STAININC IS IDENTIFIED IN 3O% Or TUMOR CELLS. THEREFORE, c-erbB2 (HER-2/NEU) IS INTERPRETED AS POSITIVE (SCORE 2+). My signature is attestation that I have personalry!. diagnosis roflects that evaluation. (LEFT BREAST,. MODIFIED RADICAL MASTECTCMY: INFILTRATING AND INTRADUCTAL CARCINOMA OE THE BREAST, POOR NUCLEAR GRADE INTRADUCTAL CARCINOMA IS COMEDO-TYPE AND COMPRISES APPROXIMATELY 35: OF TUMOR VOLUME 9CM IN-SITU COMPONENT EXTENDS TO INVOLVE LARGE NIPPLE DUCTSS NIPPL. SHOWING PAGET'S DISEASE TUMOR VASCULAR SPACE INVOLVING IS NOT PROMINENT  SURGICAL MARGINS FREE OF TUMOR IN PLANES OF SECTIONS TUSOR INVOLVES ALL FOUR QUADRANTS, HOWEVER, RANDOM SECTIONS OF QUADRANTS ARE NEGATIVE FOR TUMON
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diff --git a/output/text/b5b606d8-b86e-46a0-a613-ea0e4e3931a8.txt b/output/text/b5b606d8-b86e-46a0-a613-ea0e4e3931a8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c1b7a8b3fe3a8598e95ad1e01ad0f3f851c060ef
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+--- Page 1 ---
+TSS: 1co-0-3 SPECIMENS: A. EXCISION RIGHT BREAST NEEDLE LOCALIZATION Carcinoma nifi1trating 1o lulew,NUS B. LEFT BREAST AND AXILLARY CONTENTS C. ADDITIONAL LEFT AXILLARY TISSUE 8520/3 Situ: buut, n0s c50.9 SPECIMEN(S): A. EXCISION RIGHT BREAST NEEDLE LOCALIZATION B. LEFT BREAST AND AXILLARY CONTENTS C. ADDITIONAL LEFT AXILLARY TISSUE DIAGNOSIS: A. BREAST, RIGHT, NEEDLE LOCALIZATION EXCISIONAL BIOPSY: - DUCTAL CARCINOMA IN SITU (DCIS), CRIBRIFORM TYPE, NUCLEAR GRADE 2, WITH NECROSIS AND MICROCALCIFICATIONS. - DCIS IS PRESENT AT THE MEDIAL MARGIN, IS WITHIN O.1 CM OF THE POSTERIOR AND SUPERIOR MARGINS, AND IS WITHIN 0.2 CM OF THE ANTERIOR MARGIN. - ATYPICAL INTRADUCTAL PAPILLOMAS, 0.1 CM FROM THE MEDIAL MARGIN. - COMPLEX SCLEROSING LESION WITH EXTENSIVE LOBULAR CARCINOMAE IN SITU (LCIS), INTRADUCTAL PAPILLOMAS, SCLEROSING ADENOSIS, APOCRINE METAPLASIA, AND MICROCALCIFICATIONS. NOTE: DCIS is present in 3 of 10 slides. On a single slide, DCiS measures 0.8 cm. Immunostains were performed with appropriate positive and negative controls. SMMHC, p63, and calponin are positive,. showing no evidence of invasive carcinoma. B. BREAST, LEFT, AND AXILLARY CONTENTS, MODIFIED RADICAL MASTECTOMY:  - INVASIVE LOBULAR CARCINOMA, NOTTINGHAM GRADE 3. - 3.3 CM IN SIZE. - EXTENSIVELY INVOLVES THE NIPPLE DERMIS. - LOBULAR CARCINOMA IN SITU (LCIS), PLEOMORPHIC TYPE, WITH FOCAL NECROSIS - MARGINS, NEGATIVE FOR CARCINOMA. - ATYPICAL DUCTAL HYPERPLASIA. - METASTATIC CARCINOMA IN 20 OF 24 LYMPH NODES WITH EXTRANODAL EXTENSION, LARGEST METASTASIS IS 2.4 CM (20/24). C. ADDITIONAL AXILLARY TISSUE, LEFT, EXCISION: - METASTATIC CARCINOMA IN ONE LYMPH NODE AND TUMOR  IN FIBROADIPOSE TISSUE (1/1). NOTE: There is a 0.4 cm focus of invasive carcinoma in the fibroadipose tissue with no definite iymph. node adjacent to the focus and no breast parenchyma present. This focus is best interpreted as. extranodal extension. SYNOPTIC REPORT - BREAST Specimens Involved Specimens: A: EXCISION RIGHT BREAST NEEDLE LOCALIZATION Specimen Type: Excision Needle Localization: Yes - For mass Laterality: Right UUID:85E91C9F-9F61-4A25-B4D9-1BCBC7108F5E Invasive Tumor: Absent TCGA-E2-A2P5-01A-PR Redacted Multifocality: N/A WHO CLASSIFICATION Intraductal proliferative lesions Ductal carcinoma in situ 8500/2 DCIS present  Margins involved by DCiS: : medial margin
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+--- Page 2 ---
+TSS DCIS Type:  Cribriform DCIS Size (pure DCIS only): 0.8cm Nuclear grade: Intermediate Necrosis: Present Location of CA++: DCIS Benign epithelium ER/PR/HER2 Results ER: Positive PR: Positive Performed on Case: Pathological staging (pTN): pT is N X Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition. SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimens Involved SpecimenS: A: EXCISION RIGHT BREAST NEEDLE LOCALIZATION Specimen: Surgical Excision Block Number: A2 ER: Positive Allred Score: 8 = Proportion Score 5 + Intensity Score 3 Allred Score: 8 = Proportion Score 5 + Intensity Score 3 PR: Positive COMMENT: The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the. proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring range from 0 to 8. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2. METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours.. Immunohistochemistry was oerformed usina the mouse anti-human ER (ER 1D5, 1:100) and PR (PGR ) following the manufacturer s instructions. This. 136, 1:100) provided by assay was not modified. Interpretation of the ER/PR immunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal. review of staining performance.. SYNOPTIC REPORT - BREASTE Specimens Involved Specimens: B: LEFT BREAST AND AXILLARY CONTENTS C: ADDITIONAL LEFT AXILLARY TISSUE Specimen Type: Mastectomy Needle Localization:  No Laterality:  Left Invasive Tumor: Present Multifocality: No WHO CLASSIF!CATION  Invasive lobular carcinoma 8520/3 Tumor size:  3.3cm Tumor Site: Central Margins: Negative Distance from closest margin:  0.9cm deep Tubular Score: 3 Nuclear Grade: 3
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+--- Page 3 ---
+TSS: Mitotic Score: 2 Modified Scarff Bloom Richardson Grade:. 3 Necrosis: Absent Lobular neoplasia: LCIS Lymph nodes: Axillary dissection Lymph node status: Positive 21 / 25 Extranodal extension DCIS not present ER/PR/HER2 Results ER: Positive PR: Positive HER2: Negative by FISH Performed on Case: Pathological staging (pTN): pT 2 N 3 Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition GROSS DESCRIPTION: A. EXCISION RIGHT BREAST NEEDLE LOCALIZATION Received fresh labeled with the patient's identification and "right breast needle localization" is an oriented (short stitch-superior, long stitch-lateral, double stitch-deep), 35 g, 5.5 x 5.5 x 2.5 cm needle Iocalized lumpectomy with radiographs. Ink code: Anterior-yellow, posterior-black, medial-green, lateral- red, superior-blue, inferior-orange. The specimen is serially sectioned from medial to lateral into 7 slices revealing a 1.7 x 0.7 x 0.4 cm gritty, lobulated white tumor that is closest to the anterior margin at 0.1 cm. A clip is identified in slice 2. No additional lesions are noted. Representatively submitted: A1-medial margin A2-slice 2, superior margin A3-4-slice 2, anterior/posterior margins to tumor. A5-A8-slice 3, full cross-section/tumor A9-slice 4, additional deep margin to firmer fibrous tissue A10-lateral margin B. LEFT BREAST AND AXILLARY CONTENTSE Received fresh labeled with the patient's identification and "left breast and axillary contents" is an oriented 1150 g, 26 x 21 x 4 cm mastectomy with a 15 x 7 cm skin ellipse and 1.5 cm in diameter inverted nipple. There is also 15 x 11 cm attached axillary tissue. Ink code: Posterior-black, anterior superior-blue, anterior inferior-orange. The specimen is serially sectioned into 12 slices from medial to Iateral with nipple in slices 5/6 revealing a retroareolar, 3.3 x 3 x 2.7 cm infiltrative, gritty indurated, Iobulated tan to white tumor in slices 5 and 6, closest to the anterior margin (areolar skin) at 0.5 cm. No additional lesions are identified. There are 24 possible lymph nodes identified, ranging from 0.2 cm to 2.4 cm in greatest dimension. Representatively submitted: B1-deep margin closest to tumor, slice 5 B2-B3-entire nipple, slices5-6  B4-tumor to closest anterior (skin) margin, slice 6. B5-B7-additional tumor, slice 6 B8-UOQ, slice 9 B9-LOQ, slice 8 B10-UIQ, slice 4 B11-LIQ, slice 4 B12-superior skin margin, shave B13-6 lymph nodes  B14-one trisected lymph node B15-6 lymph nodes 816-5 lymph nodes 317-one bisected lymph node B18-2 lymph nodes B19-2 lymph nodes 820-one lymph node LH C. ADDITIONAL LEFT AXILLARY TISSUE Received in formalin labeled with patient's identification and "additional left axillary tissue" is adipose tissue measuring 3 x 2.5 x 1 cm in aggregate. Representative sections submitted in C1.
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+TSS: CLINICAL HISTORY: : year-old female with multicentric left breast cancer; FNA-positive lymph nodes and right mass biopsy shows atypia, left mass retroareolar, right atypical ductal hyperplasia at 12:00 PRE-OPERATIVE DIAGNOSIS: Invasive pleomorphic lobular carcinoma retroareolar, left breast Gross Dictation:, . Microscopic/Diagnostic Dictation:, . Microscopic/Diagnostic Dictation:, Final Review:., Pathologist, Final:., Pathologisi
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diff --git a/output/text/b5cff3fa-951d-4089-9070-13222a6ed33d.txt b/output/text/b5cff3fa-951d-4089-9070-13222a6ed33d.txt
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+UUID:F05374ED-C58F-4EE9-B593-846451113530 Redacted Surgical Pathology Consultation Report Patient Name: Accession #: MRN: Service: Collected: DOB: Visit #: Received: Gender: Location: Reported: Facility: Ordering MD: Copy To: Specimen(s) Received 1. Lymph-Node:  ST19 Splenic nodes 2. Lymph node: Station 8 3. Esophagogastric Resection: Thoracic esophagus + Proximal stomach with esophageal margin - QS. IcD-0-3 4. Lymph node: Station 7 5. Lymph node: Station 17 Oolen cs sn*maD NbS 814of3 6. Lymph node: Station 16 7. Lymph node: Additional station 7. 8. Lymph node: Additional station 8 9. Lymph node: station 4R 015.5 10. Esophagus: Final esophageal margin QJy18114 11. Esophagus: EEA donuts 12. Stomach Resection: Final gastric resection margin Diagnosis 1. Specimen labeled "Lymph node station 19 (splenic nodes)", excision:. Benign fibroadipose tissue. No lymph node(s) represented for evaluation in the submitted tissue.. There is no evidence of malignancy. 2. Lymph node station 8, excision: Metastatic adenocarcinoma in one (1) of seven (7) lymph nodes. 3. Thoracic esophagus and proximal stomach, resection: Invasive adenocarcinoma (3.4 x 3.0 x 1.2 cn), poorty differentiated, arising in the lower esophagus in the background of extensive Barrett's esophagus with focal high-grade dysplasia: Lymphovascular and perineural invasion are seen. All. evaluated surgical resection margins are negative for carcinoma.. Summary stage (incorporating all parts 1-12): pT2 pN3 pMX See synoptic report below. 4. Lymph node station 7, excision: Metastatic adenocarcinoma in one (1) of four (4) lymph nodes. 5. Lymph node station 17, excision: Metastatic adenocarcinoma in five (5) of sixteen (16) lymph nodes.. Page 1 of 5
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+Surgical Pathology Consultation Report 6. Lymph node station 16, excision: Metastatic adenocarcinoma in four (4) of nine (9) lymph nodes. 7. Additional lymph node station 7, excision:. Metastatic adenocarcinoma in one (1) of one (1) lymph node. 8. Specimen labeled "Additional lymph node station 8", excision: Benign fibroadipose tissue. No lymph node(s) represented for evaluation in the submitted tissue. There is no evidence of malignancy. 9. Lymph node station 4R, excision: There is no evidence of malignancy in two (2) of two (2) lymph nodes. 10. Final esophageal margin, resection: Benign squamous mucosa and esophageal wall.. No glandular mucosa seen. There is no evidence of malignancy. 11. EGA donuts, excision: Fragment of benign squamous mucosa and esophageal wall. Fragment of benign gastric corpus-type wall. There is no evidence of malignancy, atrophy, intestinal metaplasia, or Helicobacter-like organisms. 12. Final gastric margin, resection: Benign gastric corpus-type wall. There is no evidence of malignancy, atrophy, intestinal metaplasia, or Helicobacter-like organisms. Synoptic Data Data below integrates information from all parts 1-12.. Clinical History: Barrett's esophagus. Specimen: Esophagus Proximal stomach. Procedure: Esophagogastrectomy Primary Tumor Site: Distal esophagus (lower thoracic esophagus) Additional Sites involved by Tumor: Esophagogastric junction (EGJ)  Proximal stomach and esophagogastric junction Relationship of Tumor to Esophagogastric Junction: Tumor midpoint lies in the distal esophagus and tumor involves the esophagogastric junction Histologic Type: Adenocarcinoma Histologic Grade: G3:  Poorly differentiated Tumor Size: Greatest dimension: 3.4 cm Additional dimension: 3.0 cm Additional dimension: 1.2 cm Microscopic Tumor Extension: Tumor invades muscularis propria Proximal Margin: Uninvolved by invasive carcinoma Uninvolved by dysplasia Distal Margin: Uninvolved by invasive carcinoma Uninvolved by dysplasia Page 2 of 5
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+Surgical Pathology Consultation Report Circumferential (Adventitial) or Deep Margin: Uninvolved by invasive carcinoma All Margin Status All margins uninvolved by invasive carcinoma Distance of invasive carcinoma from closest margin: 3 mm Closest margin: Circumferential Treatment Effect: No prior treatment Lymph-Vascular Invasion: Present Perineural Invasion:. Present TNM Descriptors: Not applicable: No TNM prefix applicable Primary Tumor (pT):e pT2: Tumor invades muscularis propria. Regional Lymph Nodes (pN): pN3: 7 or more nodes involved Number of regional lymph nodes examined: 39 Number of regional lymph nodes involved: 14 Distant Metastasis (pM): Not applicable: Unknown (pMX) Additional Pathologic Findings: *Intestinal metaplasia (Barrett's esophagus) High grade dysplasia. *Pathologic Staging is based on AJCC/UICC TNM, 7th Edition Electronically verified by: Clinical History. Esophageal adenocarcinoma; Barrett's Gross Description 1.The specimen container is labeled with the patient's name and as "Lymph node station 19 (splenic nodes)". The. specimen consists of 1 piece of fibroadipose tissue measuring 3.5 x 3.0 x 1.2 cm. No grossly obvious lymph nodes are identified within the tissue.. 1A-1C submitted in toto 2.The specimen container is labeled with the patient's name and as "Station 8". The specimen consists of multiple. pieces of fibroadipose tissue measuring, in aggregate, 3.5 x 3.0 x 2.2 ch. Within the tissue are multiple possible lymph nodes ranging from 0.1 to 0.4 cm. Representative sections, identified lymph nodes submitted intact and in toto.. 2A-2B multiple intact lymph nodes per block 3. The specimen container is labeled with the patient's name and as "Thoracic esophagus and proximal stomach" RESECTION SPECIMEN: Gastroesophagectomy FIXATiON: Received fresh, placed in formalin. The adventitia! surface is painted with silver nitrate. DIMENSIONS: Length along lesser curvature:  8.0 cm Length along greater curvature:  3.5 cm. Circumference of distal gastric margin: 13.0 cm Circumference of proximal esophageal margin: 5.0 cm Length of tubular esophagus: 6.0 cm Width of tubular esophagus: 4.7 cm TUMOR LOCATION: Page 3 of 5
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+Surgical Pathology Consultation Report - Esophagus; extending through GE junction with <5% of tumor in gastric cardia. - CONFIGURATION: Diffuse, circumferential - DIMENSIONS: Diameters: 3.4 x 3.0 cm Depth: 1.2 cm - DESCRIPTIVE CHARACTERISTICS: Poorly defined with a varied appearance. There is a table top lesion (with endoscopic tip stuck in it) at the proximal aspect measuring 1.1 cm in diameter. The majority of the tumor is comprised of a broad based ulcerative lesion measuring 3.0 cm from proximal to distal x 3.4 cm in circumference. The distal edge of this has a nodular appearance in an area measuring 1.1 x 0.9 cm.. - PERFORATION: No - DISTANCE FROM MARGINS: - PROXIMAL: 2.5 cm - DISTAL: 6.5 cm - RADIAL: 0.3 cm (inked adventitial surface) ESTIMATED DEPTH OF INVASION: Into muscularis propria LESIONS IN NONCANCEROUS STOMACH: The stomach mucosa is congested LYMPH NODES: No perigastric or thoracic lymph nodes are identified within the small fragments of adherent adipose tissue FROzEN SECTION: Representative section of the esophageal margin was submitted as block 3A Tissue is stored frozen Photographs are taken. Representative Sections: 3A frozen section tissue, resubmitted 3B remaining esophageal mmargin, en face 3C-3Q every other sagittal section of esophagus moving from the greater curvature in a clockwise direction through the anterior portion first (each triplet of blocks contains one full thickness sagittal section from proximal esophagus to just beyond GE junction trisected, with the 1st block containing the proximal portion, the 2nd block containing the midportion and the 3rd block containing the distal portion) 3R-3T stomach 3U-3W gastric margin, en face. 4. The specimen container is labeled with the patient's name and as "Station 7". The specimen consists of 1 piece of fibroadipose tissue measuring 4.2 x 3.2 x 1.7 cm. Within the tissue are multiple lymph nodes ranging from 0.1 to 3.3 cm. Representative sections, lymph nodes submitted in toto.. 4A multiple intact lymph nodes. 4B 1 lymph node, bisected 4C-4D 1 lymph node, bisected 5.The specimen container is labeled with the patient's name and as "Station 17". The specimen consists of 1 piece of adipose tissue consistent with omentum measuring 11.0 x 7.5 x 2.0 cm. The tissue is congested. Within the tissue are multiple lymph nodes ranging from 0.2 to 1.3 cm. Representative sections, lymph nodes submitted in toto. 5A-5D multiple intact lymph nodes 5E 1 lymph node, bisected 6. The specimen container is labeled with the patient's name and as "Station 16". The specimen consists of 1 piece of  tibroadipose tissue measuring 11.0 x 5.5 x 1.8 cm. Within the tissue are multiple lymph nodes ranging from 0.1 to 0.6 cm. Representative sections, lymph nodes submitted in toto:. Page 4 of 5
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+Surgical Pathology Consultation Report 6A-6B muttiple intact lymph nodes 7. The specimen container is labeled with the patient's name and as "Additional station 7". The specimen consists of 2 pieces of fibroadipose tissue measuring, in aggregate, 2.0 x 1.0 x 0.3 cm.  No grossly obvious lymph nodes are identified within the tissue. 7A submitted in toto 8. The specimen container is labeled with the patient's name and as "Additional station 8". The specimen consists of 1 piece of fibroadipose tissue measuring 2.2 x 2.3 x 1.0 cm.  No grossly obvious lymph nodes are identified within the tissue, 8A-8B submitted in toto. 9. The specimen container is labeled with the patient's name and as "Station 4R". The specimen consists of 2 pieces of tan and anthracotic tissue measuring 1.0 and 1.3 cm in maximum dimension. 9A submitted in toto. 10. The specimen container is labeled with the patient's name and as "Final esophageal margin". The specimen consists of a ring of mucosa, stapled at one end, measuring 3.5 cm in diameter by 0.5 cm in length. No obvious lesion is identified. 10A tissue abutting staple line. 11. The specimen container is labeled with the patient's name and as "EGA donuts". The specimen consists of 2 pieces of pink-tan tissue consistent with mucosa. The smaller piece measures 1.2 x 0.7 x 0.2 cm. The larger piece is a circular piece held together with blue suture material with a diameter of 4.0 cm and a length of 0.9 cm. No gross lesions are identified. Submitted in toto: 11A smaller piece 11B larger piece 12. The specimen container is labeled with the patient's name and as "Final gastric resection margin". The specimen consists of a wedge resection of stomach, stapled along both edges. The specimen has a diameter of 6.5 cm and a maximum length of 3.3 cm. The staple lines measuring 8.0 cm each. One of the staple lines is partially opened. Adherent adipose tissue measures 3.5 x 2.5 x 0.1 cm. The gastric mucosa is congested at the open staple line but is otherwise unremarkable. No lymph nodes are identified within the adipose tissue. Representative sections: 12A tissue along partially open staple line 12B ventral sections 12C tissue along opposite staple line Quick Section Diagnosis. Part 3: Thoracic esophagus and proximal stomach; esophageal margin for QS: Esophageal margin negative for carcinoma Result reported at lw 12/18/13 IPAA Discrepa
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diff --git a/output/text/b5de8923-c3ad-4b3d-aecc-35bb21a2eb01.txt b/output/text/b5de8923-c3ad-4b3d-aecc-35bb21a2eb01.txt
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+Page 1 of 3 COPY ONLY DO NOT FILE SURGICAL PATHOLOGY Time Collected Time Received Time Reported Order Number Ordering Provider Status Results Final Source of Specimen A. RIGHT PERI RENAL FAT- B. RIGHT RENAL MASS- FINAL DIAGNOSIS: A. RIGHT PERI RENAL FAT- ADIPOSE TISSUE. NO CARCINOMA SEEN. B. RIGHT RENAL MASS- RENAL CELL CARCINOMA, LIMITED TO RENAL TISSUE EXAMINED. PROPORTION OF SARCOMATOID COMPONENT: O %. SPECIMEN LATERALITY: RIGHT TUMOR FOCALITY: UNIFOCAL. TUMOR SIZE (LARGEST TUMOR, IF MULTIPLE): 4 CM. HISTOLOGIC TYPE:  PAPILLARY, TYPE 1. HISTOLOGIC GRADE (FUHRMAN NUCLEAR GRADE): 2/4. TNM STAGE: pTa, pNX, pMX. LYMPH NODE(S) INCLUDED IN ALL PARTS: NUMBER EXAMINED:: LYMPHATIC (SMALL VESSEL) INVASION: IS NOT SEEN. SPECIMEN TYPE: PARTIAL NEPHRECTOMY Prepared for
+
+--- Page 2 ---
+Page 2 of 3 SPECIMEN SIZE: 4 x 3.5 x 3 CM. NO TUMOR SEEN AT RESECTION MARGINS. TUMOR IS FOCALLY PRESENT O.2 FROM THE INKED SURGICAL RESECTION MARGIN. Case Clinical RIGHT RENAL MASS Gross Description A. Received in formalin labeled with the patient's name and "right perirenal fat" is an unoriented 11 x 7 x 2.9 cm piece of tan/yellow adipose tissue.  The cut surface has a uniform, fatty, glistening appearance that is unremarkable. No occult lesions or masses are grossly identified.. Representative sections are submitted in Al-A7.. B. Received in formalin labeled with the patient's name and "right renal mass" is a previously bivalved partial nephrectomy specimen which when reconstructed measures 4 x 3.5 x 3 cm. The resection margin has been inked.. Also, in the container is a stripped capsule that has been inked blue. This measures 4 x 4 x 0.2 cm thick that is lined with a tan, glistening,. unremarkable i tissue. The cut surface reveals a 4 cm nodular mass located 0.5 cm from the resection margin grossly.. The exposed parenchyma has a tan/brown smooth appearance. Representative sections are submitted as follows: B1-B3= full thickness cross sections demonstrating mass to inked resection margin; B4-B5= mass to capsule; B6= representative sections of previously described fragment of capsule; B7= additional tumor without margin; B8= normal tissue. Procedure A. AA ROUTINE H&E X1 BLOCK.1 H&E X1 A. AA ROUTINE H&E X1 BLOCK.2 H&E Xl A. AA ROUTINE H&E X1 BLOCK.3 H&E X1 A. AA ROUTINE H&E X1 BLOCK.4 H&E X1 Prepared
+
+--- Page 3 ---
+Page 3 of 3 A. AA ROUTINE H&E X1 BLOCK.5 H&E X1 A. AA ROUTINE H&E X1 BLOCK.6 H&E X1 A. AA ROUTINE H&E X1 BLOCK.7 H&E X1 B. AA ROUTINE H&E X1 BLOCK.1 H&E X1 B. AA ROUTINE H&E X1 BLOCK.2 H&E X1 B. AA ROUTINE H&E X1 BLOCK.3 H&E Xl B. AA ROUTINE H&E X1 BLOCK.4 H&E Xl B. AA ROUTINE H&E X1 BLOCK.5 H&E X1 B. AA ROUTINE H&E X1 BLOCK.6 H&E X1 B. AA ROUTINE H&E X1 BLOCK.7 H&E X1 B. AA ROUTINE H&E X1 BLOCK.8 H&E X1 Prepared
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diff --git a/output/text/b60bb9d8-9cee-4629-b82a-70b06b68caa4.txt b/output/text/b60bb9d8-9cee-4629-b82a-70b06b68caa4.txt
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index 0000000000000000000000000000000000000000..501026c7bd1f4a4a0bdbe06c7b5e02c9d08fc3a1
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+Other Related Data: Billing Type: Financial Number: Clinical Diagnosis & History: Investigated for right pelvic pain and found to have a solid right renal mass. Specimens Submitted 1: SP: Right kidney 2: SP: Paracaval n DIAGNOSIS: 1) KIDNEY, RIGHT; NEPHRECTOMY: - RENAL CELL CARCINOMA, CHROMOPHOBE CELL TYPE. THE TUMOR GREATEST DIAMETER IS 5.2 CM. THE TUMOR IS CONFINED WITHIN THE RENAL CAPSULE. NO INVASION OF THE RENAL VEIN IS IDENTIFIED. ALL SURGICAL MARGINS ARE FREE OF TUMOR. THE NON-NEOPLASTIC KIDNEY SHOWS A SIMPLE CYST (1 CM IN DIAMETER). THE ADRENAL GLAND IS NOT SUBMITTED. 2) LYMPH NODES, PARACAVAL; EXCISION: - THREE BENIGN LYMPH NODES (O/3). Gross Description: 1)  The specimen is received fresh for frozen section, labeled. "Right kidney". It consists of a kidney, partially surrounded by yellow-tan, lobulated, perinephritic fatty tissue. The specimen weighs 420 grams and measures 12.0 x 7.0 x 5.0 cm. The kidney has a portion of ureter attached, measuring 7.5 cm in length and 0.4 cm in diameter. The ureter is probed, opened and shows a light tan, smooth and shiny inner surface. The kidney shows a smooth, shiny capsule. The specimen is bivalved. Approximately 0.4 cm close to the capsule in the center, attached to but not. extending to the pelvis, there is a well-circumscribed, pink-dark Page 1of 3
+
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+red homogeneous, soft tumor mass, measuring 5.0 x 5.2 x 4.3 cm. Approximately 1.3 cm from the capsule in the lower pole of the kidney is an oval cystic mass with a smooth surface, measuring. 1.0 x 0.8 x 0.7 cm,  containing dark brown fluid. The renal vein and artery are also probed and opened, showing a light tan, smooth and shiny inner surface. The rest of the kidney. parenchyma is grossly unremarkable. Representative sections are submitted. Tissue is sent for A photograph is taken.. Summary of Sections: FSC - Frozen section control. UM - Ureteral margin VM  Vascular margin. PLN Possible lymph nodes HF - Perihilar fat with kidney structure. CT - Relation tumor with kidney capsule. P Pelvis with attached tumor. C - Representative section of cystic mass. T Tumor RS  - Representative sections of normal kidney. 2)  The specimen is received in formalin, labeled "Paracaval lymph nodes". It consists of multiple irregular pieces of. yellow-tan fibroadipose tissue, I.  possibly containing lymph nodes, measuring 2.2 x 1.4 x 0.8 cm in aggregate. The specimen is submitted entirely. Summary of Sections: LN - Lymph nodes Histo Stain Results/Comments:. Stain/Procedure Name Result Comment CK7 CD10 IMMUNO RECUT NEGATIVE CONTROL CK7 CK7 NEGATIVE CONTROL IMMUNO RECUT CK7 NEGATIVE CONTROL CK7 CD10 IMMUNO RECUT NEGATIVE CONTROL Summary of Sections: Part Sect. SiteBlocks Pieces All 1 c 2 2 N CT 1 1 FSC 1 1 HF 2 2 P 2 2 PLN 2 M RS 1 1 Page 2 of 3
+
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+T 2 2 UM 11 1 VM 1 M 2 LN 2 M Y Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS: RENAL CORTICAL NEOPLASM. FAVOR CHROMOPHOBE RENAL CELL CARCINOMA. CASE DISCUSSED WITH DR. PERMANENT DIAGNOSIS: SAME. Page 3 of 3 END OF REPORT
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+Page 1 of 6 UUID:0093D096-4A35-4543-9FDB-838AE59F0833 TCGA-XF-A9S-01A-PR Redacted FINAL DIAGNOSIS: RADICAL CYSTECTOMY WITH BILATERAL PELVIC LYMPH NODE DISSECTION, STUDOR POUCH TO URETHRA: TaD o 3 RIGHT DISTAL URETER (A) : FROZEN SECTION DIAGNOSIS: arcinone, dsthlol ssss  NO HIGH GRADE ATYPIA OR TUMOR IDENTIFIED FINAL DIAGNOSIS: 812013 BENIGN URETER  NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED V Carsnomo,trarsetierol ceel r4E 8/2013 LEFT DISTAL URETER (B) : FROZEN SECTION DIAGNOSIS: Ste 9 Blsdder NoS  NO HIGH GRADE ATYPIA OR TUMOR IDENTIFIED Cb7 9 FINAL DIAGNOSIS: BENIGN URETER  NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED RIGHT PERIAORTIC LYMPH NODES (C) : FROZEN SECTION DIAGNOSIS: MALIGNANT FINAL DIAGNOSIS:  METASTATIC CARCINOMA IDENTIFIED IN FOUR OF TEN LYMPH NODESS EXAMINED (4/10) URINARY BLADDER AND PROSTATE (D) : APICAL URETHRAL MARGIN (DFS) : FROZEN SECTION DIAGNOSIS: NO HIGH GRADE ATYPIA OR TUMOR IDENTIFIED FINAL DIAGNOSIS: BENIGN URETHRAL AND PERIURETHRAL TISSUE  NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED URINARY BLADDER:  DIVERTICULUM EXHIBITING IN SITU (FLAT LESION) AND INVASIVE POORLY DIFFERENTIATED TRANSITIONAL CELL CARCINOMA (3.5 X 3.0 X 1.1 CM). GRADES 3 & 4/4, EXTENDING THROUGH BLADDER DIVERTICULUM WALL INTO PERIVESICAL SOFT TISSUE AND APPROACHING WITHOUT INVOLVING RIGHT URETER  NO DEFINITIVE LYMPHOVASCULAR SPACE INVASION IDENTIPIED RESECTION MARGINS AND PERITONEAL SURFACE, FREE OF UROTHELIAL DYSPLASIA AND MALIGNANCY RANDOM BLADDER MUCOSA, INCLUDING TRIGONE AND BLADDER NECK, SHOWING CHRONIC CYSTITIS WITHOUT EVIDENCE OF UROTHELIAL DYSPLASIA OR MALIGNANCY NO MALIGNANCY IDENTIFIED IN THREE PERIVESICAL LYMPH NODES EXAMINED (O/0 RIGHT, 0/3 LEFT, 0/3 TOTAL) PROSTATE: UNILATERAL PROSTATIC ADENOCARCINOMA, GLEASON' S SCORE 6 (3+3), FOCALLY EXTENDING INTO BUT NOT THROUGH CAPSULE AND NOT INVOLVING PERIPROSTATIC SOFT TISSUE APICAL, BLADDER NECK AND INKED RADIAL MARGINS, FREE OF TUMORS BILATERAL SEMINAL VESICLES, FREE OF TUMOR UNINVOLVED PROSTATIC PARENCHYMA SHOWING ACUTE AND CHRONICS INFLAMMATION, FIBROMUSCULAR ADENOMATOUS HYPERPLASIA AND HIGH GRADE PROSTATIC INTRAEPITHELIAL NEOPLASIA (PIN II AND III)  PROSTATIC URETHRA, FREE OF UROTHELIAL DYSPLASIA AND MALIGNANCY LEFT PERIAORTIC LYMPH NODES (E) :
+
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+Page 2 of 6 METASTATIC CARCINOMA IDENTIFIED IN FOUR LYMPH NODES EXAMINED (O/4) RIGHT COMMON ILIAC LYMPH NODES (F) : METASTATIC CARCINOMA IDENTIFIED IN FOUR OF TEN LYMPH NODES EXAMINED (4/10) PRESACRAL LYMPH NODES (G) : METASTATIC CARCINOMA IDENTIFIED IN NINE OF ELEVEN LYMPH NODES EXAMINED, WITH EXTRANODAL EXTENSION (9/11) RIGHT EXTERNAL ILIAC LYMPH NODES (H) :  NO METASTATIC CARCINOMA IDENTIFIED IN SIX LYMPH NODES EXAMINED (O/6) RIGHT OBTURATOR / HYPOGASTRIC LYMPH NODES (I) : METASTATIC CARCINOMA IDENTIFIED IN THREE OF 11 LYMPH NODES EXAMINED, WITH EXTRANODAL EXTENSION (3/11) LEFT EXTERNAL ILIAC LYMPH NODES (J) : NO METASTATIC CARCINOMA IDENTIFIED IN THREE LYMPH NODES EXAMINED (O/3) LEFT COMMON ILIAC LYMPH NODES (K):  NO METASTATIC CARCINOMA IDENTIFIED IN SIX LYMPH NODES EXAMINED (0/6) LEFT OBTURATOR / HYPOGASTRIC LYMPH NODES (L) :  NO METASTATIC CARCINOMA IDENTIFIED IN NINE LYMPH NODES EXAMINED (O/9) LEFT PRESCIATIC LYMPH NODES (M) :  NO METASTATIC CARCINOMA IDENTIFIED IN THREE LYMPH NODES EXAMINED (O/3) RIGHT PESCIATIC LYMPH NODE (N) : METASTATIC CARCINOMA IDENTIFIED IN ONE LYMPH NODE EXAMINED (1/1) LEFT PROXIMAL URETER (O) : BENIGN URETER  NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED RIGHT PROXIMAL URETER (P) : BENIGN URETER  NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED PATHOLOGIC TNM STAGE: URINARY BLADDER: pTis, T3bN2MX PROSTATE : pT2aN0MX INTRAOPERATIVE DIAGNOSIS: FROZEN SECTION DIAGNOSIS: AFS: Right distal ureter:  no high grade atypia or tumor identified BFs: Left distal ureter:  no high grade atypia or tumor identified CFS: Right periaortic lymph nodes: - malignant DFS:  Urinary bladder and prostate, apical urethral margin:  no high grade atypia or tumor identified
+
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+Page 3 of 6 GROSS DESCRIPTION: A: The specimen is received fresh from the O.R. and labeled "Right distal ureter.". It consists of a segment of ureter measuring 0.3 cm in length and 0.3 cm in diameter with adjacent fat. The specimen is entirely submitted for frozen section in cassette AFs. B The specimen is received fresh from the O.R. and labeled "Left distal ureter." It consists of a segment of ureter measuing 0.5 cm in length and o.3 cm in diameter. The specimen is submitted with adjacent fatty tissue. The specimen is. entirely submitted for frozen section in cassette Brs.. C: The specimen is received fresh from the O.R. and labeled "Right peri aortic lymph nodes." It consists of a segment of fatty tissue containing lymph nodes measuring 4.5 x 3.5 x 1.5 cm.  The largest node measures 1 cm in greatest dimension. The largest node is submitted for frozen section in cassette cFs. The remaining tissue is entirely submitted in two cassettes. D: The specimen is received fresh from the O.R. and labeled sUrinary bladder & prostate." It consists of bladder with bilateral ureters, prostate and peritoneum. measuring overall 24 x 17 x 4.5 cm. The peritoneum measures 21 x 15 x 0.1 cm, and there are adhesions located on its lower aspect..  The margins are inked. The apical margin is removed and submitted for frozen section diagnosis. The bladder and the prostate are opened anteriorly. The bladder measures 9.5 x 8 x 3.5 cm. Opening reveals a large diverticulum 5 x 5 x 5 cm located on the right lateral bladder wall 2 cm above the ureterovesical junction.  The mouth of the diverticulum measures 2 cm in diameter..  The diverticulum is opened and reveals a gray-white, firm tumor located on the base of the diverticulum.  The surface of the tumor, 3.5 x 3.0 cm. The tumor invades through the full thickness of the muscularis propria of the thin diverticulum wall, and involves the surrounding soft tissue to a depth. of 1.1 cm. The tumor comes within 2 mm of the inked radial margin.  There is a 1 cm scarred area of mucosa located between the mouth of the diverticulum and the right ureterovesical junction..  The remaining bladder mucosa is intact with a trabecular appearance. The bilateral ureters are opened. Opening reveals a smooth and unremarkable mucosa. The right ureter measures 7 cm in length and 1.4 cm in circumference. The right ureter is adherent to tumor but the mucosa is uninvolved by tumor grossly.  The uninvolved bladder wall measures 0.8 cm in thickness.. The prostate measures 5.5 x 4 x 4 cm. The prostatic urethra measures 3 cm in length and 3 cm in circumference.  The prostatic urethra is excavated proximally:. The verumontanum measures 1.3 x 0.3 x 0.3 cm. The prostate is serially sectioned.. Sectioning reveals a well-circumscribed, white-tan nodule located on the apical portion of the prostate measuring o.5 cm in greatest dimension..  The remaining prostatic parenchyma is tan, smooth and unremarkable. Representative sections are submitted in 33 cassettes.. E: The specimen is received in formalin and labeled "Left peri aortic lymph nodes." It consists of a piece of yellow fatty tissue measuring 3 x 2 x 1 cm.  The specimen is entirely submitted in one cassette.. F:  The specimen is received in formalin and labeled "Right common iliac lymph nodes." It consists of a piece of yellow-tan fatty tissue measuring 6 x 3 x 2.5 cm.  There is a large lymph node identified measuring 3 cm in maximum dimension. The specimen is entirely submitted in five cassettes.. G:  The specimen is received in formalin and labeled "presacral lymph nodes." It consists of a piece of yellow-tan fatty tissue measuring 7 x 6 x 3 cm.  There are multiple lymph nodes identified.  Representative sections are submitted in five cassettes.
+
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+Page 4 of 6 H:  The specimen is received in formalin and labeled "Right external. iliac lymph nodes." It consists of a piece of yellow-tan fatty tissue measuring 3.5 x 2 x 1 cm. The specimen is entirely submitted in one cassette. I:  The specimen is received in formalin and labeled "Right obturator / hypogastric lymph nodes." It consists of a piece of yellow tan fatty tissue measuring 8~x 6 x 3 cm.  There are multiple large iymph nodes identified. ' The largest node measures 3 cm in maximum dimension. Representative sections are submitted in eight. cassettes. J:  The specimen is received in formalin and labeled "Left external iliac lymph nodes." It consists of two pieces of yellow fatty tissue measuring 4 x 3 x 1 cm in aggregate. There is a large lymph node identified measuring 2 cm in maximum. dimension. The specimen is entirely submitted in two cassettes. K:  The specimen is received in formalin and labeled "Left common iliac lymph nodes." It consists of yellow fatty tissue measuring 3 x 2 x 1 cm.. There are multiple lymph nodes identified. Representative sections are submitted in two Cassettes. L  The specimen is received in formalin and labeled "Left obturator / hypogastric lymph nodes." It consists of a piece of yellow fatty tissue measuring 7 x 6 x 2.5 cm. There are multiple lymph nodes identified. The largest one measures 3 cm in maximum dimension. Representative sections are submitted in four cassettes. M The specimen is received in formalin and labeled "Left presciatic lymph nodes." It consists of multiple pieces of yellow fatty tissue measuring 2.5 x 2 x 1 cm in aggregate. The specimen is entirely submitted'in one cassette.. N: The specimen is received in formalin and labeled "Right presciatic lymph nodes."  It consists of multiple pieces of yellow-tan fatty tissue measuring 3 x 2 x 1 cm in aggregate. The sepcimen is entirely submitted in one cassette.  The specimen is received in formalin and labeled "Left proximal ureter." It consists of a segment of ureter measuring 0.6 cm in length and 0.4 cm in diameter. The specimen is serially sectioned and entirely submitted in one cassette. P: The specimen is received in formalin and labeled "Right proximal ureter." It consists of a segment of ureter with surrounding fatty tissue measuring 1 cm in sections are submitted in one cassette. SECTIONS: AFS : frozen section, right distal ureter BFs: frozen section, left distal ureter ces: frozen section, right periaortic lymph nodes C1,2: remaining tissue DFS: apical urethral margin D1: anterior bladder mucosa D2 : tumor relationship with ureter. D3,4: tumor with closest deep margin D5 : tumor D6.7: tumor with adjacent bladder mucosa D8 : diverticulum wall D9 : right ureterovesical junction. D10: dome D11: posterior bladder mucosa D12: left lateral bladder mucosa D13: left ureter vesicle junction D14: trigone
+
+--- Page 5 ---
+Page 5 of 6 D15: scarring bladder mucosa between diverticulum and right junction D16: right perivesical fat with possible lymph nodes D17: left perivesical fat with possible lymph nodes D18: right seminal vesical D19: left seminal vesicle D20: right anterior distal prostate D21: right posterior distal prostate D22: left anterior distal prostate D23: left posterior distal prostate D24 : right posterior midprostate D25: left posterior midprostate D26: right anterior 2nd mid prostate D27 : right posterior 2nd midprostate D28: right anterior 2nd midprostate D29: left posterior 2nd midprostate D30: right anterior proximal prostate D31: right posterior proximal prostate D32: left anterior proximal prostate D33: left posterior proximal prostate E: left periaortic lymph nodes all embedded F1: right common iliac lymph nodes; largest lymph node bisected F2-5: multiple lymph nodes G1-5: presacral iymph nodes representative sections H: right external iliac lymph nodes all embedded. 11: right obturator/hypogastric lymph nodes; portion of largest lymph node. 12-5: one lymph node, serially sectioned each 16-8: multiple lymph nodes J1 : left external iliac lymph nodes; largest lymph node J2 : possible lymph node K1,2: left common iliac lymph nodes representative sections L1,2: left obturator/hypogastric lymph nodes; multiple lymph nodes. L3 : one lymph node serially sectioned L4 : portion of largest lymph node M: left presciatic lymph nodes all embedded N: right presciatic iymph nodes all embedded 0: left proximal ureter' all embedded p: right proximal ureter  representative sections MICROSCOPIC DESCRIPTION: A-C: See final microscopic-diagnosis. D:  Sections of the bladder show an invasive poorly differentiated transitional cell carcinoma, grades 3 & 4/4 (D2-7). A focus of in situ carcinoma is seen adjacent to the invasive tumor (D7).  The invasive tumor is characterized by cords, nests and solid sheets of poorly differentiated transitional cells.. The tumor extends through the bladder wali into the surrounding perivesical fat.. The tumor is adjacent to but does not invade the right ureter (Dz). Tumor is present 1 mm from the closest inked radial margin (D4) on the right lateral side.. Lymphovascular space invasion is seen (D5).. Random sections of the bladder outside the diverticulum show no evidence of urothelial dysplasia or neoplasia but do demonstrate the presence of chronic cystitis. Previous biopsy sites are seen in sections taken from between the right ureterovesical junction and diverticulum. Sections of the prostate show unilateral (left) prostatic adenocarcinoma (D23,29), Gleason' s score 6 (3+3). The tumor is characterized by variably sized glandular structures that infiltrate the stroma. The tumor is confined to the prostate with focal involvement of the capsule, without penetration into periprostatic soft tissue.  All margins as well as bilateral seminal vesicles are
+
+--- Page 6 ---
+Page 6 of 6 free of tumor.. malignancy. E-P: See final microscopic-diagnosis. Signed by: ELECTRONIC SIGNATURE POST-OPERATIVE DIAGNOSIS: Same PRE-OPERATIVE DIAGNOSIS: Muscle invasive bladder cancer ORDERING PHSYCIAN: Ordering Physician:. AAA
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diff --git a/output/text/b667024f-9e08-42dc-9e9e-c0bf01703830.txt b/output/text/b667024f-9e08-42dc-9e9e-c0bf01703830.txt
new file mode 100644
index 0000000000000000000000000000000000000000..174650c72ee692dc910a05f128328f6be13e9d5c
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+
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+UUID:3552E70E-B26A-426D-993C-0D1A3CC9442B TCGA-4A-A93Y-01A-PR Redacted SURGICAL PATHOLOGy REPORT Patient: Result ID: Accession: DOB: Age. Sex: F Account:  Date Collected: MRN: Date Received: Patient Requested by Date Reported: Clinical Data: Left renal mass FInAL pathologic diagnosis ICD 03 Left kidney, radical nephrectomy with adrenal gland: Papillary renal cell carcinoma. Unremarkable adrenal gland. Synoptic RepORt Tumor site: Left kidney, superior pole yJ 3/2w(14 Tumor size: Greatest dimension: 12.5 cm Tumor focality: Unifocal Microscopic extent of tumor: Tumor timited to kidney Histologic type: Papillary renal cell carcinoma, type 2 Margins: Uninvolved by invasive carcinoma Gerota's fascial margin: Negative for tumor Renal vein margin: Negative for tumor Ureteral margin: Negative for tumor Regional lymph nodes: One hilar lymph node is negative for tumor (0/1) Additional findings: Unremarkable adrenal gland Pathologic Tumor Stage: pT2b pN0 Pathologist, Electronic Signature Intradepartmental consultation: SpEcimen(s) SubmItteD: gROss DescriptiOn Left kidney: In formalin labeled "left kidney" is a 762 gram, 16.5 x 11.5 x 10 cm nephrectomy specimen with attached perinephric fat, attached 8 cm of ureter., and a 6 cm attached adrenal gland. Upon sectioning in the superior pole, there is a. 12.5 cm in greatest dimension lobulated tumor. The cut surfaces of the tumor are lobulated mottled orange-red to brown, with  diffuse hemorrhage and necrosis. The tumor abuts and elevates the renal capsule; however, no definitive invasion beyond the capsule into the perinephric fat is appreciated. The tumor also appears to abut the renal pelvic/calyceal mucosa, with no gross invasion into or through the mucosa. No involvement of the ureter or gross involvement of the vasculature is appreciated. The remaining cut surfaces are pink-brown renal parenchyma with a defined corticomedullary junction. The cut surfaces of the  adrenal gland are mottled grey-orange to brown, with no tumor involvement. There is a '1.3 cm lymph node at the kldney hilum. Page 1 of 2
+
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+SURGICAL PATHOLOGY REPORT - CONTINUED Patient:  Resuit ID:  Accession: The perinephric soft tissue margin is inked black. Representative sections submitted in six cassettes, as follows: A - ureter and vascular margins; B - tumor to renal capsule and inked perinephric soft tissue margin; C - tumor to renal capsule; D - tumor to renal pelvis/calyces; E - uninvolved kidney and adrenal gland; and F - hilar lymph node, bisected. Following initial microscopic evalation, additional sections of tumor are submitted as G-I. CPT CODE(S): ICD-9 CODE(S): FACILITY: [1890] 88309, 88307 END OF REPORT 12|13/13
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diff --git a/output/text/b679fc59-11aa-4460-ae26-92cff17d931c.txt b/output/text/b679fc59-11aa-4460-ae26-92cff17d931c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6d48b7e82f1bfb98107be737ff66fdcb56e59309
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:D64FFDC0-388B-456E-9621-AF8937900C68 tcga-a7-a13F-01a-pr Redacted SPECIMEN A. Sentinel lymph node #l, right axilla, count 422 B. Sentinel node #2, right axilla, count 2600 C. Left breast tissue, single stitch - superior, double stitch - medial D.  Right breast ((dc) ics-g.? CLINICAL NOTES Ca^rirona. d.fiinntiny Dust, ros. PRE-OP DIAGNOSIS: Right breast Ca 1500/3 FROZEN SECTION DIAGNOSIS Sitx. brsst, Nos c5o.9. +/u.. A. Sentinel node 1, right axillary: No tumor seen. No definite lymph node. B. Sentinel node II right axillary, biopsy: two lymph nodes, both positive for metatatic carcinoma. GROSS DESCRIPTION A. The specimen is received fresh for frozen section labeled "sentinel node #l right axilla" and consists of a 3.0 x 2.0 x 1.0 cm. piece of fatty yellow tissue. The specimen is sectioned to reveal a possible 0.6 cm. tan lymph node. No staining is present. The possible lymph node tissue is frozen as frozen section AFsl. The fatty tissue is entirely submitted in block 1 for permanent sections.. B. The specimen is received fresh for frozen section labeled "B. sentinel node #2 right axilla" is a 6.0 x 3.0 x 1.0 cm. piece of soft yellow fatty tissue. The specimen is palpated and sectioned to reveal two possible lymph nodes. One measures 1.5 cm. in greatest dimension and has a focally firm white-tan appearance. The other measures 1.0 cm. in greatest dimension and appears tan and soft. The larger lymph node is frozen as frozen section BFsl and the smaller as frozen section BFs2. Both lymph nodes are bisected. GROSS DESCRIPTION C. The specimen is received in formalin labeled "left breast tissue" and consists of a V-shaped piece of white skin with underlying yellow soft tissue, two additional pieces of yellow soft tissue and an additional piece of white skin. The entire specimen weighs 480 grams in the partially fixed state. On cut section the breast tissue is unremarkable. RS-8 D. The specimen is received in formalin labeled "right breast" and consists of a right breast resection specimen measuring 35 x 21 x 6 cm. There is an overlying white ellipse of skin measuring 21 x 9 cm. The skin ellipse has a central areola measuring 4.5 x 4 cm. with a central nipple measuring 1.3 x 1 x 0.2 cm. An arrow has been incised in the skin ellipse. The deep surface of the specimen has been inked and the breast has been partially
+
+--- Page 2 ---
+sectioned prior to my examination. There is a deep central tumor a portion of which has been resected prior to my examination,. probably for research purposes. The tumor measures 6 x 4 x 7 cm. The specimen is re-incised at 1 cm. intervals from the deep surface towards the skin. Sections are taken as dictated in the block summary:. BLOck suMMARy: 1 and 2 - nipple; 3 - deep margin; 4-7 - tumor; 8- 11 -- upper outer, upper inner, lower outer, lower inner quadrants.. Sections from the axillary portion of the specimen show 1i lymph node-like structures. These are submitted in blocks D12-Dl7. MICROSCOPIC DESCRIPTION A. Fibrofatty connective tissue is present. The specimen is negative for malignancy.. B. Metastatic carcinoma is present in 2 of 2 lymph nodes. The. largest nodules measure 0.2 and 0.5 cm..  There is focal benign calcification.. D. MICROSCOPIC DESCRIPTION Invasive carcinoma Tumor type: Infiltrating ductal caricnoma with focal. lobular features Tumor grade: 2 (Elston SBR grade; A/N/M = 3/2/1) Mitotic index: 4 mitoses/10 HPFs (l HPF = 0.196 sq mm) Tumor size: 4 x 6 x 7 cm Vessel invasion: Carcinoma is present in lymphatics in the nipple. Calcification: Absent pTNM stage: T3 pNla Prognostic markers: See previous biopsy Nipple: Carcinoma is present in lymphatics in the nipple Skin over tumor: Negative for malignancy Deep margin: Negative for malignancy Total lymph nodes: 11 (including 2 sentinel nodes). Lymph nodes positive: 3 (including 2 sentinel nodes) Size of metastases: Up to 3.5 mm Extranodal tumor: Absent Matted lymph nodes:. Absent 4x2,3,5,14x2,15
+
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+DIAGNOSIS A. Sentinel lymph node #l, right axilla, biopsy:. Fibrofatty connective tissue. No lymph node present. B. Sentinal lymph node #2, right axilla, biopsy:. Metastatic carcinoma is present in 2 of 2 lymph nodes. C. Breast, left, plastic procedure:.  Negative for malignancy D. Breast, right, resection:. DIAGNOSIS Infiltrating ductal carcinoma with focal lobular features, /Nottingham grade 2 Note: Metatstatic carcinoma is present in 1 of 9 axillary lymph nodes. M.D. (Electronic Signature) --- End Of Report --- 1DC - pu Si Asuirez
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diff --git a/output/text/b69eb70c-b8e1-4848-af22-2c315e2c051a.txt b/output/text/b69eb70c-b8e1-4848-af22-2c315e2c051a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8cd5a2085e457cb50843561c917486b2b80920a1
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+DOCTOR: DATE OF SERVICE: Pathology Consultation Report Final CASE : UUID:67B47EFA-A6C9-40B6-AF17-8A4E1FF6656B ANATOMIC PATHOLOGY DIAGNOSIS: Redacted TCGA-F3-A3Z7-01A-PR A - Ureter, right, discal, segmental resection .Focal low grade dysplasia Ureter, left, distal, resection - No pathologic diagnosis - Apical urethral surgical margin, resection - Urothelial with reactive atypia D . Urinary bladder, radical cystectomy Urothelial carcinoma of the urinary bladder (transitional carcinoma) 1cs-0-3 High grade (grade 3/3) - Solid pattern 7 cm Cosciono, hrothclinl Nos 813cf3  Invasion into the inner half of the muscular propria  Multifocal lymphovascular invasion Sife: b1addy Nos cl7.9 All surgical margins (right and left ureteral, urethral and soft tissue margins) h free of tunor involvement 9/38/12 Carcinoma in situ/high dysplasia, multifocal, involving urothelium.  Brunner's nest with high grade dysplasia/carcinoma in situ Granulomatous inflammation ot the mucosa Reactive changes of the mucosa Right ureter, high grade dysplasia/carcinoma in situ Left ureter, high grade dysplasia/carcinoma in situ Prostate, pending microscopic examination E - Left pelvic lymph nodes, dissection  One out ten lymph nodes with microscopic metastatic carcinoma F . Right pelvic lymph nodes, dissection - Two out of eleven lymph nodes with metastatic carcinoma G - Left common iliac lymph nodes, excision Eleven lymph nodes without carcinoma H - Right common iliac lymph nodes, dissection Six lymph nodes without metastatic carcinoma I - Presacral lymph nodes, resection Page 1 of 11
+
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+Six lymph nodes without metastatic carcinoma J - Para-aortic lymph nodes, excision Iwo lymph nodes without metastatic carcinoma K - Precaval lymph node, excision One lymph node without metastatic carcinoma L - Discarded segment of bowel, segmental resection Small bowel wall without diagnostic alteration M - Proximal margin, left ureter, excision No pathologic diagnosis N - Distal right ureter, segmental resection Focal low grade dysplasia PATHOLOGIST: I have reviewed this material and confirm the report. Released by electronic signature on: MATERIAL: A. Right distal ureter; a. Left distal ureter: c. Apical margin. D. Urinary bladder E. Left pelvic lymph nodes. F. Right pelvie lymph nodes. G. Left common lliac lymph nodes. H. Right common iliac lymph nodes. Pre-sacral lymph nodes. J. Para-aortic lymph nodes. K. Pre-caval I lymgh nodes. L. Discarded segment of small bowel. M. Proximal margin of left ureter. N. Distal right ureter. O. Prostate. INTRAOPERATIVE DIAGNOSIS: FROZEN SECTION DIAGNOSIS AFS Right distal ureter excision - Lower grade dysplasia versus high grade dysplasia; suggest additional resection - (Reported to BFS Left distal ureter excision Page 2 of l1
+
+--- Page 3 ---
+No dysplasia NAME No carcinoma - (Reported to CFS Atypical urethral margin, biopsy. - No dysplasia - No carcinoma (Reported to HISTORY: with bladder cancer. GROSS: A-Received fresh labeled as right distal ureter is a tan pink. unoriented segment of ureter (0.2 x 0.2 x 0.2 cm). Entirely submitted for frozen section in AFs.. 3-Received fresh labeled as left distal ureter is a tan pink unoriented segment of ureter (0.3 x 0.3 x 0.2 cm). Entirely submitted for frozen section in sFs. } C-Received fresh labeled apical ureteral margin is a tan-pink,. unoriented, irregular piece of tissue measuring lx0.5x0.3cm. Entirely submitted for frozen section in crs.. D. A radical cystoprostatectomy specimen consisting of a urinary bladder (9.0 x 7.0 x 2.0 cm when opened); a prostate gland; and. attached perivesical adipose tissue (overall measurements: 15.0 x 6.0 x 4.0 cm). Located in the anterior, posterior, right, and left walls of the urinary bladder, there is a nodular firm lesion (7.0 x 4.5 cm).. Sections through the lesion exhibit a firm white lesio that extends to a depth of 2.Ocm into the muscularis and adipose tissue. The ureters are not identified in the specimen. The remainder of the urinary bladder mucosa is edematous and red. The specimen is sequentially sectioned inferior portion to the dome, and representative sections are submitted in thirty-five cassettes: D1-D35. Ink code: alue - anterior Black - posterior Red - right Orange - left Section code: D1 Anterior right bladder wall. D2 Posterior bladder wall. D3 Posterior bladder wall. D4 Anterior left bladder wall D5 Anterior right bladder wall. D6 Right bladder wall. Page 3 of 11
+
+--- Page 4 ---
+D7 Left bladder wall. D8  Right anterior bladder wall D9 Right posterior bladder wall D10 Left posterior bladder wall 011 Right posterior bladder wall (possible ureter) D12 Left posterior bladder wall (possible ureter) D13 Left anterior bladder wall D14 Right posterior bladder wall D15 Left posterior bladder wall 017 Posterior central bladder wall D18 Posterior right bladder wall D19 Left posterior bladder wall  D20 Posterior central bladder wall D21 Left anterior edematous area D22 Posterior central bladder wall D23 Anterior left bladder wall D24 Right posterior bladder wall D25 Right posterior bladder wall D26 Left posterior bladder wall D27 Right posterior bladder wall. D28 Left anterior and posterior bladder wall D29 Deepest right posterior portion of lesion D30 Left posterior bladder wall D31 Representative section of dome D32 Representative section, dome D33 Representative section of dome D34 Possible lymph node D35 Fossible lymph nodes E-Received in formalin, labeled "left pelvic lynph nodes", are multiple pieces of tan-yellow fibroadipose tissue, aggregating to 9.5 x 5.5 x 2.5 cm in size.. Twelve possible lymph nodes, ranging in size from o.5. x 0.3 x 0.2 cm to 3.0 x 2.0 x 1.7 cm in size are dissected. The cut surfaces of all the above lymph nodes are tan-brown with interspersed The lymph nodes are subnitted as follows: E1-Es single lymph node, serially sectioned, submitted entirely E6-E8 single lymph node, serially sectioned, submitted entirely. E9 two lymph nodes, submitted entirely. E10 two possible lymph nodes. submitted entirely E11 two possible lymph nodes, submitted entirely E12 four possible lymph nodes, submitted entirely F-Received in formalin, labeled "right pelvic lymph nodes', are. multiple pieces of fibroadipose tissue, aggregating to 8.5 x 6.0 x 2.5 cm in size. Eleven possible lymph nodes, ranging in diameter from 0.5 x 0.5 x 0.2 cm to 3.0 x 2.4 x 2.0 cm in size are dissected. The cut surface of the lymph nodes is tan-pink with interspersed fatty areas. The lymph nodes are submitted as follows: F1-F3 single lymph node, serially sectioned, submitted entirely Page 4 of 11.
+
+--- Page 5 ---
+F4-Fs single lymph node, serially aectioned, submitted entirely . F6-F8 single lymph nod, serially sectioned, submitted entirely. E9 F10 four possible lymph nodes, submitted entirely F11 single lymph node, submitted entirely G-Received in formalin labeled as "left common iliac lymph nodes" are multiple fragments of tan-yellow lobulated fibroadipose tissue (5.5 x 4.0 x 0.9 cm). The specimen is predominantly yellow lobulated adipose tissue with streaks of tan fibrosis and multiple possible lymph nodes. The specimen is serially sectioned and multiple possible lymph nodes. are identified ranging in size from 0.4 x 0.3 x 0.2 cm up to 1.1 x 1.0 x 0.5 cm. Multiple lymph nodes are submitted entirely in five. cassettes, G1-g5. Section Code: G1 one lymph node, bisected G2 four possible lymph nodes 03 two possible lymph nodes G4 two possible lymph nodes G5 two possible lymph nodes H-Received in formalin labeled "right common iliac lymph nodes" is a apecimen of fibrofatty tissue (5.4 x 2.4 x 1.0 cn). The external surface of the tissue is primarily yellow lobulated adipose tissue. The specimen is serially sectioned and multiple possible lymph nodes x Q.6 cm). Representative sections are submitted in four cassettes,. H1-H4. Section Code: H1 two possible lymph nodes, submitted entirely H2 one possible lymph node, submitted entirely H3 two possible lymph nodes, submitted entirely H14 one lymph node, bisected, submitted entirely I-Received in formalin labeled, as *pre-sacral lymph nodes" is a 4.0 x 3.0 x 0.5 cm irregular portion of adipose tissue. The specimen is serially sectioned and six lymph nodes are identified ranging in size from 0.4 to 1.3 cm. Section Code: I1 one lymph node 12 two lymph nodes I3 three lymph nodes J-Received in formalin labeled, as "para-aortic lymph nodes" are two tan-pink lymph nodes measuring c.8 and 1.0 cm in greatest dimension #ach. Section Code: J1 one lymph node, trisected Page s of 11
+
+--- Page 6 ---
+one lymph node, trisected.. K-Received in formalin labeled, as "pre-caval lymph nodes' are two lymph nodes measuring 2.0 and 3.0 cm. Section Code: K1 one lymph node K2 One lymph node. L-Received in formalin. labeled 'discarded segment of bowel". is a segment of bowel (4.4 x 2.5 x 1.6 cm). The specimen is not oriented. The specimen is stapled closed and has a tan-pink serosal surface with attached mesenteric adipose tissue. The specimen is opened and the ulcers, or grossly identitiable lesions. Representative sections are submitted in three cassettes, labeled Ll-L3. M-Received in Earmalin, labeled *proximal margin, left ureter", ia a ureter with attached tissue (2.3 x 2.0 x 0.6 cm). The external surface of the tissue is yellow-pink, aoft, and lobulated. One staple is attached to the specimen. A ureter is identified and serially sectioned. Cut surface is without lesions or masses. Representative sections are submitted in two cassettes, labeled Ml-m2. Section Code: M1-M2 proximal margin of left ureter, submitted entirely on end N-Received in formalin, labeled "distal right ureter', is a ureter specimen with attached tissue (2.3 x 1.1 x 0.5 cm). The external surface ot the tissue is tan-pink with attached lobulated adipose tissue. One staple is identified on the specimen. The specimen is serially sectioned and no masses or lesions are identified grossly. The specimen is submitted entirely in cassettes Nl-N2. Section Code: N1-N2 distal right ureter, serially sectioned. submitted entirely MICROSCOPIC:  - Sections show cross sections of ureter with low grade dysplasia involving the urothelium. Obvious high grade dysplasia or invasive carcinoma is not identified. C - Sections show urothelial together with underlying muscle. reactive atypia of the urothelium. Dysplasia is not identified. There is Page 6 of 11
+
+--- Page 7 ---
+D - Sections show urothelial carcinoma, high grade (transitional cell carcinoma grade 3/3). The tumor shows a solid growth pattern. There is minimal papillary formation. The tumor invades into the inner half of the muscularis propria. There are many areas of lymphovascular invasion wirhin the cumor mass, at the from the main tumor mass. There is no obvious perineural invasion. The surgical margins (right and left ureral, urethral and soft tissue margins) are free of tumor involvement. The urothelium adjacent to the invasive carcinoma show high grade dysplasia/carcinoma in situ. The urothelium away from the main tumor shows several changes including reactive atypia, low grade dysplasia. high grade dysplasia/carcinoma in situ. Brunner's nests with high grade dysplasia/ carcinoma in situ are present. Several arean of the urothelium are lost. The mucosa shows a few granulomas with multinucleated giant cells. There is also tibrosis, acute and chronic inflammation of the mucosal portion not involved by tumor tissue.. Sections of the right and left ureters show focal areas of high grade dysplasia/carcinoma in situ. E - Sections show ten lymph nodes. One of them show a microscopic focus of metastatic transitional cell carcinoma. F - Sections show eleven lymph nodes, two of them show metastatic carcinoma.  The maximum size of the metastases are about 3 mm in lymph Jodes meauring up to 3.5 mm and 6 mm, respectively. G - Sections show eleven lymph nodes without metastatic carcinoma. H - Sections show six lymph nodes without metastatic carcinoma. I - Sections show six lymph nodes without metastatic carcinoma. J - Sections show two lymph nodes without metastatic carcinoma. K - Sections show one lymph node without metastatic carcinoma L - Sections show terminal ileal wall with no diagnostics alteration. M - Sections show cross sections of ureter with no dysplasia or carcinoma invasive. N - Sections show cross section of ureter with focal low grade dysplaaia. High grade dysplasia or carcinoma is not identified. Page 7 of 11
+
+--- Page 8 ---
+TUMOR SYNOPTIC REPORT AND STAGING: Specimen: Procedure: Radical cystectomy with nodal dissection Tumor size: 7cm Kistologic type: Urothelial carcinoma, high grade Itransition cell carcinoma grsde 3/3) Associated epithelial Lesion: Multifocal high grade dysplasia/ carcinoma in situ Histologic grade: High grade Microscopic tumor extension: Involvement of the inner halt of the muscularis Margin status: Negative Lymphovascular invasion Multifocal. lymphovascular invasion Primary tumor: T2a Lymph node N2 Distant Metastasis: MO Stage grouping: Stage IV Site of distant metastases None Page l of 1 SURGICAL PATHOLOGY DICTATED BY: This report was verified electronically. Page 8 of 1l
+
+--- Page 9 ---
+DATE OF DISCHARGE DOCTOR: DATE OF SERVICE: Pathology Consultation Report Supplemental CASE: REASON FOR ADDENDUM: Addendum issued to repot findings of gross and microscopic examination of prostate following formalin fixation and whole-mount processing. ANATOMIC PATHOLOGY DIAGNOSIS: Prostate, radical cystoprostatectomy. Focal invasive urothelial carcinoma into prostatic stroma Extensive urothelial carcinoma in-situ involving prostate, with prostatic duct and acinar involvement. Urathelial carcinoma in situ involving ejaculatory duct and seminal vesicle No lymphovascular invasion seen. No prostate adenocarcinoma  Margins negative for urothelial carcinoma. PATHOLOGIST: I have reviewed this material and confirm the report. Released by electronic signature on: MATERIAL: O. Prostate.. HISTORY: with bladder cancer. GROSS: O. Received in formalin.and labeled prostate is a prostate with attached bilateral seminal vesicles which tagether weigh 94g. The. prostate itself weighs 64g, and measures 4.5cm inferior to superior;. 6.0cm transversely; and 6.Ocm anterior to posterior. Page 9 of 11.
+
+--- Page 10 ---
+Following formalin fixation. the prostate margins are inked: the right side in black, the left eide in blue. Cut surfaces of nonsurgical margins are inked as orange. The apical margin is removed and submitted in a cone-like fashion. The remainder of the gland is sectioned bilaterally in the sagitcal plane along either side of the prostatic urethra. Cut surfaces are smooth pink to tan glistening, with areas of large nodularity and cystic structures. The apex orifice is irregular and dilated to 1.Ocm in greatest dimension. The prostatic urethra is hemorrhagic, with focal areas of necrosis.. The seminal vesicles have gray-white, senitranslucent walls ot normal thickness. Section code:. P1-4 Apex margin P Whole-mount prostate, sagittal plane, left side P6 Whole-mount prostate, sagittal plane, right side. p7-13 Sequential sections of prostate, apex to base, left side P14-21 Sequential sections prostate, apex to base, right side P22  Representative sections of left seminal vesicles. P23  Representative section, right seminal vesicles. MICROSCOPIC: Sections of prostate show extensive urothelial carcinoma in-situ  nvolving almost entire prostate. There are ductal as well as acinar +nvolvement. Focal stromal invasive carcinoma is seen. In addition, CIS involving ejaculatory duct and seminal vesicle is also noted. No lymphovascular invasion is identified. There is no prostate. adenocaricnoma. All margins are negative for tumor.. COMMENT: Intradepartmental consultation:. (P5 and P6) TUMOR SYNOPTIC REPORT AND STAGING:S Specimen (include all): Urinary bladder, prostate, extended pelvic lymph node dissection specimens. Procedure type: Radical cystoprostatectomy and extended PLND Tumor size: 7 cm Histologia type: Invasive urothelial carcinoma. Associated epithelial lesions: crs. Histologic grade (low or high): High grade Microscopic tumor extension: Tumor invades bladder muscularis propria and prostate. stroma Page 10 of 11
+
+--- Page 11 ---
+Margin status: Negative Lymphovascular invasion: Yes. Primary tumor (pT): pT4a Lymph node (pN): pN2 Distant metastasis (M): cMO Stage grouping: IV Sites of distant metastasis: Unknown Page 1 of i. SURGICAL PATHOLOGY DICTATED BY: This report was verified electronically. Page ll of 11.
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diff --git a/output/text/b6a319aa-68cc-49ec-9a61-1cdc3a5e1347.txt b/output/text/b6a319aa-68cc-49ec-9a61-1cdc3a5e1347.txt
new file mode 100644
index 0000000000000000000000000000000000000000..aa350b22300337814b03e93d8a88729427d59484
--- /dev/null
+++ b/output/text/b6a319aa-68cc-49ec-9a61-1cdc3a5e1347.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:9B82DA05-E85D-44EB-8E97-BD002DD309550 tCgA-2z-A931-01A-PR Redacted Pathology Report Cender X Service: Received Peported: Submitting Physiclang: Fathoiogsts Intraop.Pathoiogtet Pertormang Physiciang CLINICAL HISTORY YEAR-CLD MALE.WITHRENAL MASS 33 CM.SMOKED STOPPEDIN HYPERTENSION, (STENTS X 2 IN ID63 nenaQuQL 8a6tJ3 PREOPERATIVE DIAGNCSIS: LEFT RENAL MASS N6S C 649 SPHCIMEN TYPE(S) A: TIP OF IITH RIA, GEOSS CNLY HLEFT FERI NEPHmIC FAT FS 4/a8/14) CLEFT PENALMASSFS DABDOMINAL.WALL LESION FINAL DIAGNCSIS: A. TIDOFIITH RIB,RXCISICN Iortion cr wnreaarkable rin (Grosg Diagnoais Cniy). rertior.a or muscie ann adipose tiasue witn no signiricant pathological change. A. *LEFT PERINEPHRICFAT.KXCISION: Ri5roadipose caaue, negative ror carcinoma. C. LEFT SENAL MASSPARTIAL NEPHPECTOMY Renai cell carctnoma, papiliary type, Funrmani muclear gride 23 ot 4. Sea key ratnolog:cal Findings.  PATHCLOGICAL FINDINGS Tumor typer Penal celi carcinoma,.papillary type. Muclesr grade: Punrnan nuciear grade 2-3 or. 4.. Pattern cr growtn Sotu. Tumor stze: 3.0.cm Extexa Knrough Renal Capaule? Not identi ted Invsaion.ot Cerota's Paacia Notappi.cabie Not appiicable. Surnica argine Freer wever. carcinoca present les than ls. trom Farenchysal reeection sargin. Non-reoplastie k:dncyt Miid cnronie. inriammatten. Agrenal gland: Not appicabie. Lymph. rodes: Not.apptcable. Fatnoicqic.stages. TlaNXM Yes D. ARDOMINAL WALL LRSION,* RXCIS:CN: Benign verrucotd.keracoaia (see Coument) cormenx: Tne dirrerent:al diagnoses inciuce vezruco!d seborrneic xeratosis,. xegressing yerruca, anu in an appropriate clinical background a variant of consyloma acuminatum. witrout apparentassociated Hry.seaturea concura.with the diagnoais alideDi) the attending patnolog:st, personally reviewen the entire pathiogy
+
+--- Page 2 ---
+case and cendared the Cinal itagnosis. Rlectrcnicaliy signed out by OTHER RELATED CLINICAL LATA NA INTRAOPERATIVE DIAGNOSTS: FrOzEN SECTION DIAgNOS!S. LEFT PERINEPHRICFAT: Consistent with rat, ns. avidence. or ma:ignancy: FSCL, LEFT RENAL MASS Malignant rena) neoplsas. Tne tumor ia lese than 1 mm trom the inxei resectien 1. Cormenr: Tnia fiozen aection a:agnos!a/result was ccsmunicated to and acxnewledge1 by . MD' have perrermed tne intraoperative consultat.onans issued tne abeve diagncses. EROSSDESCRIPTON: . Specimen A is received rresn atelen *tip bt ith rib grosa cnly.* The specimen censiata o: 3.3-cm in lengtn portion ct tib vitn grossiy unrezarxabla xeacction 7argin and witn.3.0 x a.0 x 1,s-cm Sttacned rragment. or'tan/ red brown musc!e. No. tissue in sbmitted to the tisaue procurenent iiborstory..Representative cection of the musce sutitted in I cadeette, A. Specimenn iareceivec frest iateled *lett pertnephric.rat rule.putcancer. :nxea margin" sne apec.men coneiars or 1.s x 3.s x d.6-cm srreguiar rragment ot tan pale-yellow, sore, sobulatad adipoae tisaue. Tne specimen 1s.or:ented accarding to the aurgeona designation ans resection margin inkedblack Tre specimen13 serialiy sectioned to reveal .grosaly unremarkable cut surrase. Representative sectionar tre apecimen sumitted ror frozensection. analysa.and rrcren secttan sbmitte in 1 cassette Fs. Spacimec isronetved trash lateled *ect renal maaa.* Te.apeimen consist or 3.5 x 3.2 x 2.2-cm partial nephrectomy specinan. Prier to aectioning, tne specimen in 3socws Parenchynal reaection margins Black on secticning, the spec:men reveais, an.irreguiar-to-ovoid, sott, tocally Hemorrnagie ana necrotta tanor measuring 3.d. xz.a x ?.0 cm. Tne turcs.ia teiging. tut.aoes not. appear to axtona tnrougn t.he renal capsuie. Tre. tumor ie loas.than .1 on trom tne clcaest parenchymai sasection margin, whtcn ig inked blacr. Representative aectiors os the apecimen with Cumor in relation to clsseet. paxenenyrai resection nargin aurmitced toz frezen section anaiyaia and troxen. soction ramnant. aunmitted in 3 casaeste: rscl- Repreaentasive secticns subnitted to tne kiaaue procuremene iaroratory.. Adaitional sections or tne tumor eubmitted in 4 cassettos,cl4. D. Specimen  is roceived Iresh.lateled *abdominal wall lesion.* Tnespecimen censista or 'an trzegular-to-ovak.unortepted rragment ot tad-graysxin conetatent witn exophytic lesionseasuring i.3x.1.0 x d.4 cm. The resection margin ot.tne Jesion is inken tlacxt Tmne apecmen is seriaiiy sectioned and eubmitted enttrely in aeettaD. HIPA
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diff --git a/output/text/b6a88574-33d4-4da7-bf1f-da786517efde.txt b/output/text/b6a88574-33d4-4da7-bf1f-da786517efde.txt
new file mode 100644
index 0000000000000000000000000000000000000000..209fade6aaf7dee897f80bfeba306aa9d4f3d840
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+
+--- Page 1 ---
+UUID:9A5C8EDF-9243-4F55-9036-A400CF3F4CC1 TCGA-Z7-A8R6-01A-PR  Redacted *ADDENDUM* Addendum #1 Entered: BREAST CANCER PROGNOSTIC MARKERS Specimen: Paraffin block 3A Procedures: Paraffin Section Immunohistochemistry and DNA Flow Cytometry ASSAYS: ReSuLTS: FAVORABLE RANGES: Estrogen Receptors Positive, 2-3+ Positive (1 - 3+) Progesterone Receptors Positive, 3+ Positive (1 - 3+) Ploidy/DNA Index (DI) Aneuploid, DI=1.19, 2.01 Diploid, DI = 1.0 S-phase Fraction (%) Not Reported ** Low (3% or 1ess) Ki-67 (Proliferation marker) High, 40-50% Low (15% or 1ess) HER-2/neu (c-erb b2)* Negative (0) Negative (0 - 1+) p53 weakly Positive Negative ** s-phase fraction is not reported due to multiple aneuploid peaks. *This immunoperoxidase test was developed and its performance characteristics determined by xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx. A1though not cleared or approved by the U.s.Food and Drug Administration, the FDA has determined that such clearance or approva7 is not necessary. This test is used for clinical purposes and should not be regarded as investigational or for research. This laboratory is certified under the c1inical Laboratory Improvement Amendments of 1988 (cLIA) as qualified to perform high complexity clinical' laboratory testing. ID.6-3 'areini r,plemwyshi 8`OQQ 13 Addendum Signed signature on file S.te : C>Ysuast,mdlire c50.8 J16/80114 Page 1
+
+--- Page 2 ---
+GROSS DESCRIPTION 1. Labeled "blue node, left axilla": The specimen consists of a bilobed blue dye stained apparent lymph node and fatty tissue. The fatty tissue is trimmed, revealing a 1ymph node that measures 1.6 x 1.0 x 0.4 cm. It is bisected and a1l embedded as 1A. Cytokeratin stain. 2. Labeled "suspicious node, left axilla": The specimen consists of a tan yellow Fi rm  apparent lymph node that measures 1.0 x 0.5 x 0.3 cm. Bisected and all embedded as. 2A. 3. Labeled "segment, left breast, long stitch anterolateral, short stitch anteromedia1": The specimen consists of a blue dye stained piece of yellow tan tissue with orienting stitches. It measures 3.2 cm medial to lateral, 2.8 cm superior to inferior and 4.4 cm in depth. At the deep aspect of the tissue, there is a firm gritty tan nodule. The specimen is inked as follows: anterior - yellow, green - superior, black - lateral, blue - inferior, red - medial, orange - deep. 'Sections through the tissue show a gritty solid tan mass at the deep lateral aspect of the specimen, measuring 2.0 x 2.0 x 1.7 cm.. Representative tumor and_normal tissue are provided for xxxx research studies (irB# xxxxxxxxxxxxxx). Multiple representative sections are embedded serial1y from posterior to anterior as 3A-g (tumor in blocks 3A-d).. 4.. Labeled "addition segment, left breast, no orientation": The specimen consists of four pieces of yellow tan hemorrhagic and blue dye stained tissue that measure in aggregate approximately 6.0 x 3.0 x 2.0 cm. The tissue is focal1y firm, but no definite. tumor is identified grossly. Multiple representative sections are embedded as 4A-D, 4e- - additional firm areas of tissue. 5. Labeled "left breast lower quadrant mass": The specimen consists of three pieces of firm and soft tissue that measure in aggregate approximately 2.0 x 1.3 x 1.0 cm. One piece represents a firm gray nodule, or portion thereof, measuring 1.4 x 0.8 c 0.2 cm.. The entire nodule and representative other tissue is embedded as 5A-B. 6. Labeled "inferior margin left breast": The specimen consists of a piece of gray yellow tissue that measures 2.3 x 1.0 x 0.3 cm. Embedded as 6A.. 7. Labeled "superior margin left breast": The specimen consists of a piece of b1ue dye stained yellow tissue that measures 1.2 x 1.0 x 0.2 cm. Embedded as 7A. Labeled "medial margin, left breast": The specimen consists of a piece of gray. yellow tissue that measures 2.2 x 1.3 x 0.3 cm. Embedded as 8A. 9. Labeled "lateral margin, left breast": The specimen consists of a piece of. Page 2
+
+--- Page 3 ---
+reddi sh yellow and gray tissue that measures 1.5 x 0.6 x 0.2 cm. Embedded as 9A. 10. Labeled "anterior margin, left breast": The specimen consists of a piece of gray tissue that measures 1.6 x 0.6 x 0.2 cm. Embedded as 10A. 11. Labeled "deep margin, left breast": The specimen consists of a piece of yellow red tissue that measures 1.5 x 1.4 x 0.2 cm. Embedded as 11A. 12. Labeled "left breast lower quadrant skin": The specimen consists of a piece of gray pink tissue that measures 1.0 x 0.5 x 0.2 cm. Embedded as 12A.. Microscopic h&e stained sections are prepared and interpreted. MICROSCOPIC Sections show an infiltrating mammary carcinoma characterized by poor tubule formation, intermediate nuclear grade and high mitotic activity. The tumor cells infiltrate as sheets, single file, alveolar nests and occasional larger nests. The tumor has a tendency to infiltrate around existing ductal structures and focally formd targetoid lesions around this. Focal early necrosis is noted. There is a desmoplastic stromal response. IMMUNOCYTOCHEMISTRY RESULTSE Block 1A Keratin: Negative Block 3A E-Cadherin: Negative DIAGNOSIS 1. Sentinel lymph node, AxillA, Left, biopsy: ONE LYMPH NODE, NEGATIVE FOR METASTATIC CARCINOMA BY H&E EXAMINATION (0/1). 2. Lymph node, AxIlLA, Left, biopsy: ONE LYMPH NODE, NEGATIVE FOR METASTATIC CARCINOMA (O/1). 3. Breast, Left, segmentectomy: INFILTRATING LOBULAR CARCINOMA, PLEOMORPHIC TYPE, POORLy DIFFERENTIATED, 2.0 CM. NO IN SITU COMPONENT SEEN. NO DEFINITE LyMPHOVASCULAR INVASION IDENTIFIED. FOCAL BIOPSY RELATED CHANGES NOTED. TUMOR INVOLVES POSTERIOR, LATERAL AND SUPERIOR MARGINS (SEE ADDITIONAL SEGMENT AND SEPARATELy SUBMITTED MARGINS BELOW). Page 3
+
+--- Page 4 ---
+ADDITIONAL FINDINGS INCLUDE ATYPICAL LOBULAR HYPERPLASIA AND FIBROCYSTIC CHANGE. MICROCALCIFICATIONS NOTED ASSOCIATED WITH BENIGN GLANDULAR ELEMENTS. 4. Breast, Left, Additional segment, Segmentectomy: ATYPICAL LOBULAR HYPERPLASIA. - NO ADDITIONAL CARCINOMA SEEN. DDITIONAL FINDINGS INCLUDE FRADIAL SCAR FORMATION AND FIBROCYSTIC CHANGE WITH FIBROADENOMATOUS CHANGE. 5. Breast, Left, LOWEr Quadrant, eXcisIonAl bIopSy: CLUSTERED, CYSTICALLY DILATED DUCTS WITH PAPILLOMA FORMATION AND STROMAL FIbrOSiS, ' CONSiSteNt WITH RADIal SCAR. NEGATIVE FOR ATYPIA AND MALIGNANCY. 6. BREASt, LEFt, INFERIOR MARGIN, BIOPSY: BENIGN BREAST PARENCHYMA WITH RADIAL SCAR FORMATION. NEGATIVE FOR MALIGNANCY. 7. Breast, Left, SuperIor margin, biopsy: BENIGN BREAST PARENCHYMA. NEGATIVE FOR MALIGNANCY. 8. BREAST, LEFT, MEDIAL MARGIN, BIOPSY: BENIGN BREAST PARENCHYMA. NEGATIVE FOR MALIGNANCY. 9. BreaSt, LEFt, LATerAl mArgIn, BIopSy: BENIGN BREAST PARENCHYMA. NEGATIVE FOR MALIGNANCY. 10. BREAST, LEFT, ANTERIOR MARGIN, BIOPSY: BENIGN BREAST PARENCHYMA. NEGATIVE FOR MALIGNANCY. 11. Breast, Left, Deep margin, Biopsy: BENIGN SKELETAL MUSCLE AND FIBROADIPOSE TISSUE. NEGATIVE FOR MALIGNANCY. 12. SKIN, BREAST, LEFT, LOWER QUADRANT, BIOPSY: MINIMAL SUPERFICIAL PERIVASCULAR CHRONIC INFLAMMATION. NO INTRALYMPHATIC TUMOR SEEN. NEGATIVE FOR MALIGNANCY. BREAST CANCER PROGNOSTIC SUMMARY Site: LEFT BREAST 1-2 O'CLOCK TUMOR SIZE: 2.0 CM TUMOR TYPE: INFILTRATING LOBULAR CARCINOMA,  PLEOMORPHIC TYPE HIStOLOgIC GrADE: POORLY DIFFERENTIATED MODIFIED BLOOM-- RICHARDSON SCORE: 8/9 (TUBULES 3, NUCLEI 2, MITOSES 3) IN SITU CARCINOMA: NOT PRESENT TyPE: EXTENSIVE IN SITU CARCINOMA: MARGINS OF RESECTION: POSTERIOR, LATERAL AND SUPERIOR SEGMENTS MARGINS OF INITIAL SEGMENT ARE POSITIVE. ADDITIONAL SEGMENTS AND SIX SEPARATELY SUBMITTED MARGIN BIOPSIES ARE NEGATIVE. NIPPLE/SKIN INVOLVEMENT: CANNOT ASSESS Page 4
+
+--- Page 5 ---
+LYMPHOVASCULAR INVASION: NOT IDENTIFIED Lymph nodes: NEGATIVE # POSITIVE/TOTAL COUNT: 0/2 SENTINEL NODE: NEGATIVE (1) TNM PATHOLOGIC STAgE: pT1c NO (sn)(i-) MX MOLECULAR STUDIES: BLOCK 3A Signed Electronically signed by: ** END OF REPORT ** Page 5
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diff --git a/output/text/b6c5ab4f-cf9e-42f5-a7d2-8b997b0a4087.txt b/output/text/b6c5ab4f-cf9e-42f5-a7d2-8b997b0a4087.txt
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index 0000000000000000000000000000000000000000..676011d9c3eb88a54c108dcfa81a3d6f521fcea4
--- /dev/null
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+
+--- Page 1 ---
+UUID:6853F577-5E86-4AF5-9773-3654D3432BE4 Redacted TCGA-AN-A0FN-01A-PRE TSS Patient ID: Case #: DOB: Sex: Ethnicity Race) Cancer Sample Diagnosis: Breast Cancer Histological description: Infiltrative lobular carcinoma Date of Procurement: Anatomic Site: Right breast Tumor location: Primary. Tissue Specification: Tumor Specimen Matrix: Tissue Specimen Format: OCT Container: block Type of Procurement: surgery Grade: 2 T Stage: 1 N Stage: 0 M Stage: 0 Treatment: none. Treatment Details: n/a Normal Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw Matrix: Blood Specimen Format: frozen Container: tube Date of Procurement: Ics-0-3 CQcF: chuiomu,mf{tns#ny cuchl, vos 8500f3 carcnoma,m`fH#rnfng 1cbule,N1s 8530/3 Path : Sihe: hruast, Nos c50.9. 10/21f1 Path Npnt shows tumres 1obulw md CqcF shts FcgA Hmris ducthl.aftw enail corfurnctn wsL fo b duchl. 10f2u/ ff
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diff --git a/output/text/b6c85142-0ed7-46fc-b8b2-9f471f0881b1.txt b/output/text/b6c85142-0ed7-46fc-b8b2-9f471f0881b1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2473e6506e236457187937af261b3b0fc3a7e9bb
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+
+--- Page 1 ---
+FINAL DIAGNOSIS: PArt 1: LEft AXILLARy SEnTInel Lymph nOde #1, BiOpSy - One LymPH NODE, nEGATiVE fOR METASTATIC CARcInOmA (0/1). Part 2: breast, Left, total mastectomy -- A. TWO fOCI Of inyASIVE DUctAL CARCInOMA, nOTTInGhAm GRADe 2 (tUBULE fORmATION 3, nUCLEAR GrADE 2, miTOtIc RATe 1; tOTal SCORE 6/9) wIth ASsOciated mIcrOcaLCiFicaTiONS. B. THE FIRST fOCUS MEASURES 2.0 CM AnD IS PRESENT AT 3 O'CLOCK POSITION AT THE JUNCTION OF LOWer Outer and upper Outer quadrants. c. THE SECOND fOCUs mEASUreS 0.15 Cm (1.5 mm) AnD IS PRESEnt In ThE LOWEr OUTEr QUADRAnT. D. NO LYMPHOVASCULAR SPACE INVASION IS SEEN. E. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 2, SOLID AND CRIBRIFORM TYPE WITH COMEDO NECROSIS AND ASSOCIATED MICROCALCIFICATIONS. F. DCIS IS PRESENT ADMIXED AND OUTSIDE OF INVASIVE CARCINOMA AND COMPRISES APPROXIMATELY 70% OF TOTAL TUMOR VOLUME G. DCIS iS SEEN iN ELEVEN OUt Of TWEnTy SLIDES in THe UPPER OUTER AnD LOWER OUTER QUADRANTS. H. INKED MARGINS OF RESECTION ARE NEGATIVE FOR CARCINOMA. 1. INVASIVE AND IN SITU CARCINOMA LESS THAN 1 MM AWAY FROM THE CLOSEST DEEP MARGIN (AT 3 O'clOCk POSItIOn, LOWeR OuteR quaDrant). J. ATYPICAL DUCTAL HYPERPLASIA. K. FIBROCYSTIC CHANGES WITH BENIGN EPITHELIAL CALCIFICATIONS. L.. SKIN AND NIPPLE, NEGATIVE FOR TUMOR. M. BIOPSY SITE CHANGES (see comment). N.  INVASIVE TUMOR CELLS ARE POSITIVE FOR ESTROGEN RECEPTOR, NEGATIVE FOR PROGESTERONE RECEPTOR. AND POSITIVE fOR HER-2/NEU WITH A SCORE OF 3+, AS PER PREVIOUS PATHOLOGY RepOrt( Part 3: Left AxillAry Sentinel Lymph node #2, biOpsy - ONE LymPh nODE, nEGATIVE fOR METASTATIC CARCINOMA (0/1). PArt 4: LEft AxIlLAry SEntinel Lymph NODe #3, BIOpSy - .ONE LYMPH nODE. nEGATIVE FOR METASTATIC CARCINOMA (0/1). CASE SYNOPSIS: 1cs-0- 3 SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST Cucinomu nfiHraHay ductf, nos 850sf3 LATeRALITy: Left PROcEDUrE: Simple mastectomy Site: brust Nos C5o.9 3/isu h LOCATION: Upper outer quadrant Lower outer quadrant SIZE OF TUMOR:  Maximum dimension invasive component: 2.0 cm. MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: Yes TUMOR AGGREGATE SiZE: Sum of the sizes of multiple invasive tumors: 2.15 cm. TUMOR TYPE (invasive component): Ductal adenocarcinoma, NOS NOTTINGHAM SCORE: Nuclear grade: 2 UUIO:E5784989-102F-44FD-8F82-0627143FA904 Tubule formation: 3 TCGA-BH-A0HY-01A-PR Mitotic activity score: 1 Redacted Total Nottingham score: 6 Nottingham grade (1, 2, 3): 2 ANGIOLYMPHATIC INVASION: No DERMAL LYMPHATIC INVASION:  No CALCIFICATION: Yes, malignant zones Tumor type, in shu: Criororn Solid DCIS admixed and outside of invasive carcinoma component. Percent of tumor occupied by in situ component: 70 % SURGICAL MARGINS iNVOLVED BY INVASIVE COMPONENT:  No Distance of invasive tumor to closest margin: 1 mm SURG MARGINS INVOLVED BY iN SITU COMPONENT: No Distance of in situ disease to closest margin: 1 mm Lymph nODes pOsiTive: 0 LYMPH NODES EXAMINED: 3 Criteri METHOD(S) OF LymPh NODE EXAMInATION: H/E stain t Stage, pathologic: pT1c N StagE, PathOlOgIC:  pNO M STage, pAthOlOgIC: pMX ESTROGEN RECEPTORS: positive PROGESTERONE RECEPTORS: negative HER2/NEU: 3+
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diff --git a/output/text/b708df96-59fb-4925-b400-b1ca7aace5e4.txt b/output/text/b708df96-59fb-4925-b400-b1ca7aace5e4.txt
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index 0000000000000000000000000000000000000000..51284add8dc4c4e6d6a6ca77608c547087d0cbc4
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+UUID:11BD5D8D-FB5B-4D96-A421-EC8524E8AA6C TCGA-VM-A8C8-01A-PR Redacted porany ACCESSION tcD-O-3 Sigodendrogsma,gade II Submitting Physician 9 4s0|3 Clinical History Sele Low-grade glioma ctLF: Brsin, euyratinteuas NOS Diagnosis C71.0 1. BRAIN TUMOR, UNSPECIFIED SITE, RESECTION: nK: Cerbrum 71D - OLIGODENDROGLIOMA, WHO GRADE II 2. BRAIN TUMOR, UNSPECIFIED SITE, RESECTION:S Q n1a 3 - OLIGODENDROGLIOMA, WHO GRADE II I certify that I personally conducted the diagnostic evaluation on the above specimens and have rendered the above diagnosis(es): electronic signature For questions regarding this case, call Frozen Section Diagnosis. Frozen section diagnosis per 1FA: "Low-grade glioma" Gross Description Two specimens are received labeled with the patient's name and medical record number. Specimen one is received fresh for frozen section labeled "tumor", and consists of an aggregate of pink-tan soft tissue fragments measuring 1.3 x 1.0 x.0.2 cm. A representative section is submitted for frozen section. After frozen section the specimen is wrapped, transferred and submitted in cassette iFA for permanents.  The remainder of the specimen is submitted in cassette 1A. of pink-tan, irregular soft tissue fragments measuring 2.2 x 1.2 x 0.5 cm. Submitted entirely in cassette 2A. Microscopic Examination. Performed. The frozen section diagnosis is confirmed on permanent sections. Synoptic Report College of American Pathologists (cAp) Cancer Protocol
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+uroPatn Fnalkepor emearancony  Pathology Cancer Case Summary. Checklist Surgica Protocol effective date: History of Previous Tumor/ Familial Syndrome. Not specified Specimen Type/Procedure Resection Specimen Handling Squash/smear/touch preparation Frozen section Unfrozen for routine permanent paraffin sections Specimen Size Greatest dimension: 2.2 cm Laterality Not specified Tumor site Brain/cerebrum Histologic Type and Grade (applicable World Health Organization (who] classification and grade) Oligodendroglioma (who grade II) Histologic Grade (who histologic grade). WHO grade II Ancillary Studies Immunohistochemistry MIB-1 - fields with up to 10% proliferation inde: Molecular genetic studies: 1p FISH - pending 19q FISH - pending Additional Pathological Findings. None
+
+--- Page 3 ---
+ACCESSION Addendum Discussion Fluore rescence in-situ hybridization (Fish) analysis for deletions of 1p and/or 19q are performed on sections from block "2A". Calculated 1p/1q ratio= 0.98 (<0.74 is.deleted) Calculated 19q/i9p ratio = 0.90 (<0.88 is deleted) The results are interpreted as not deleted for both 1p and 19q. A result of a deleted 1p and 19q suggests a favorable prognosis.  A solitary 1p deletion suggests an intermediate prognosis. A 19q solitary deletion may suggest a favorable prognosis in a smaller subset of tumors." The lack of either 1p and/or with decreased disease-free survival and overall survival. There is no change to the original diagnosis.. I certify that I personally conducted the. diagnostic evaluation on the above specimen(s) and have rendered the above diagnosis(es):. electronic signature
+
+--- Page 4 ---
+ACCESSION Addendum Discussion At the request of the clinicians, immunohistochemistry for IDH-1 was performed on this tumor. The tumor is diffusely positive for Idh-i, making it likely that the tumor is mutated for IDh-1. The diagnosis is unchanged. This test was developed and its performance characteristics determined by The u.s. Food and Drug Administration has not approved or cleared this test; however, FdA clearance or approval is not currently required for clinical diagnosis or patient management decisions. I certify that I personally conducted the diagnostic evaluation on the above specimen(s) and have rendered the above diagnosis(es): electronic signature
+
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+ACCESSION Addendum Discussion MGMT METHYLATION ASSAY : GENE METHYLATION DETECTED. MGMr Methylation Assay was performed on sections from block "2A" by. The results of this assay are reported below: MGMT Methylation Assay: Result: Gene Methylation detected. Methylation Score: 27.13 --REFERENCE VALUE-- unmethylated <2.00 methylated >=2.00 Background: MGMT [0(6)-methylguanine-DNA methyltransferase] is a' DNA repair enzyme that is involved in the repair of damage caused by a variety of. Dna crosslinking compounds,. including alkylating agents.  Increased methylation of the Mgmr gene promotor region causes diminished or silenced expression of the gene, making cells more. sensitive to DNA damage..  This relationship has been shown for glioblastomas and alkylating agents such as temozolomide.  Approximately 40-50% of glioblastomas exhibit MGmr gene methylation. Retrospective studies have shown that detection of. MGMr promotor methylation in tumor samples is associated with an increased. likelihood of a favorable response to temozolomide. Methodology:.  DNA is isolated from formalin-fixed, paraffin-embedded (Frpe) 'specimens. Molecular analvsis of the MGmr gene is performed by methylation-specific pCR and detected on. The MGmt and beta-Actin copy numbers are used to calculate the ratio of MGmr/beta-Actin x 1ooo. Molecular-based testing is highly accurate,. but as in any laboratory test,. rare diagnostic errors may occur. Resuits of this test are for Investigational Purposes Only.. The performance characteristics of this assay have been determined by The result should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically established diagnostic product or procedure. I certify that I personally conducted the diagnostic evaluation on the above specimen(s) and have rendered the above diagnosis(es): electronic signature
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diff --git a/output/text/b70b70f5-8ca8-4a07-82f6-1d29257da639.txt b/output/text/b70b70f5-8ca8-4a07-82f6-1d29257da639.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e896d386215f7a5ef0869cf133ca63626d3dd4fe
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+/cs-0-3 TSS Pol S,ts; bust, loww ortn zusdrurt c50.5 SPECIMENS: CQcF sits brst,n0s c5U.9 A. SUBAREOLAR TISSUE RIGHT BREAST H/1S/u B. SENTINEL LYMPH NODE #1 RIGHT AX!LLA C. SENTINEL LYMPH NODE #2 RIGHT AXILLA D. SENTINEL LYMPH NODE #3 RIGHT AXILLA E. SENTINEL LYMPH NODE #4 RIGHT AXILLA F. RIGHT BREAST G. LEFT BREAST SKIN UUID:AS14658A-FB29-4AA0-9451-2A960B3720C10 TCGA-E2-A1LS-01A-PR Redacted SPECIMEN(S): A. SUBAREOLAR TISSUE RIGHT BREAST B. SENTINEL LYMPH NODE #1 RIGHT AXILLA C. SENTINEL LYMPH NODE #2 RIGHT AXILLA D. SENTINEL LYMPH NODE #3 RIGHT AXILLA E. SENTINEL LYMPH NODE #4 RIGHT AXILLA F. RIGhT BREAST G. LEFT BREAST SKIN GROSS DESCRIPTION:E A. SUBAREOLAR TISSUE RIGHT BREAST  Received fresh labeled with the patient's identification and 'subareolar tissue right breast' is an oriented 5 x 4 x 0.5cm oriented fragment of fibrofatty tissue. Suture at final margin (nipple). Final margin is inked  green; remainder of specimen is inked black. The specimen is serially sectioned and representatively submitted in FSA1-FSA2. Representatively submitted in A3-A4. B. SENTINEL LYMPH NODE #1 RIGHT AXILLA  Received fresh labeled with the patient's identification and 'sentinel lymph node #1 right axilla' are two tan-pink lymph nodes 1 x 0.8 x 0.5cm and 0.6 x 0.5 x 0.5cm. The specimens are sectioned and two touch preps are taken. B1: one lymph node B2: one lymph node C. SENTINEL LYMPH NODE #2 RIGHT AXILLA Received fresh labeled with the patient's identification and 'sentinel lymph node #2 right axilla' is a tan- pink lymph node 1.2 x 1 x 0.5cm. The specimen is sectioned and a touch prep is taken.. Toto C1. D. SENTINEL LYMPH NODE #3 RIGHT AXILLA Received fresh labeled with the patient's identification and 'sentinel lymph node #3 right axilla' is a tan- pink lymph node 0.7 x 0.5 x 0.5cm. The specimen is sectioned and a touch prep is taken. Toto D1. E. SENTINEL LYMPH NODE #4 RIGHT AXILLA Received fresh labeled with the patient's identification and 'sentinel lymph node #4 right axilla' is a tan- pink lymph node 1.8 x 0.5 x 0.3cm. The specimen is sectioned and a touch prep is taken.. Toto E1. F. RIGHT BREAST Received fresh labeled with the patient's identification and "left breast" is a 222g, 18.5 x 16 x 2.3cm oriented (stitch in axilla) simple mastectomy with attached 4.3 x 2cm tan-pink skin ellipse. The skin surface is grossly unremarkable. Ink code: anterior-superior: blue, anterior-inferior: orange, areola- green, posterior-black. The specimen is serially sectioned from lateral to medial into 15 slices, revealing a 2 x 1.8 x 1.6cm tan-pink, firm, well-circumscribed mass, 0.2cm from the deep margin and 2.4cm from the skin surface in the LOQ-LC of slices 6-7. A 0.3 x 0.2 x 0.2cm firm, nodular area is identified, 3.2cm from the deep margin and 1.2cm from the anterior-inferior margin of the LC of slices 10-11. The small nodule is 2.2cm inferior to the areolar stitch. A portion of the specimen is submitted for tissue procurement. Representatively submitted: F1: LOQ slice 5 F2-F3: UOQ slice 6 F4: LOQ with skin slice 6 F5-F6: mass with deep margin LOQ slice 6 F7: UOQ slice 7 F8-F9: mass with deep margin LOQ slice 7 F10: UOQ slice 8 F11: LOQ slice 8 F12: UOQ slice 9 F13: nodule LC slice 10
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+TSS. F14-F15: subareolar UC slice 10 F16: subareolar stitch UIQ slice 11 F17: nodule LIQ slice 11 G. LEFT BREAST SKIN Received in formalin labeled with the patient's identification and 'left breast skin' are two unoriented tan- pink fragments of unremarkable skin 3.2 x 1.8 x 0.4cm and 6.5 x 3 x 0.5cm. The specimens are serially sectioned and representatively submitted in G1. DIAGNOSIS: A. BREAST, RIGHT, SUBAREOLAR, EXCISION: - INTRADUCTAL PAPILLOMA (O.3-CM), NO TUMOR SEEN. B. LYMPH NODES, SENTINEL #1, RIGHT AXILLA, EXCISION: - TWO LYMPH NODES, NEGATIVE FOR METASTASES (O/2). C. LYMPH NODE, SENTINEL #2, RIGHT AXILLA, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1). D. LYMPH NODE, SENTINEL #3, RIGHT AXILLA, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1). E. LYMPH NODE, SENTINEL #4, RIGHT AXILLA, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1). F. BREAST, RIGHT, MASTECTOMY: - INVASIVE DUCTAL CARCINOMA, SBR GRADE 3, MEASURING 1.8 CM - INTERMEDIATE NUCLEAR GRADE, DUCTAL CARCINOMA IN SITU, SOLID TYPE WITH LOBULAR EXTENSION - SURGICAL RESECTION MARGINS NEGATIVE FOR TUMOR - LOBULAR CARCINOMA IN SITU - BIOPSY SITE CHANGES WITH FIBROSIS - TWO RADIAL SCARS - SEE SYNOPTIC REPORT AND SEE NOTE. G. SKIn, Left BREaST, EXCISION: - SKIN AND SUBCUTANEOUS SOFT TISSUE, NO TUMOR SEEN. NOTE: In addition to the tumor mass, 2 radial scars and one area of usual ductal hyperplasia without atypia are seen in the lower inner, upper inner and lower central, respectively. SYNOPTIC REPORT - BREASTE Specimen Type: Mastectomy Needle Localization: No Laterality:  Right Invasive Tumor: Present Multifocality: No WHO CLASSIFICATION  Invasive ductal carcinoma, NOs 8500/3 Tumor size: 1.8cm Tumor Site:  Lower outer quadrant  Negative Margins: Distance from closest margin:  0.2cm deep Tubular Score: 3 Nuclear Grade: 3 Mitotic Score: 3 Modified Scarff Bloom Richardson Grade: 3 Necrosis: Absent Vascular/Lymphatic Invasion: None identified. Lobular neoplasia: LCIS
+
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+TSS: Lymph nodes: Sentinel lymph node Lymph node status: Negative 0/5 DCIS present Margins uninvolved by DCIS DCIS Quantity: Estimate 10% DCIS Type:  Solid DCIS Location: Associated with invasive tumor Nuclear grade: Intermediate Necrosis: Absent ER/PR/HER2 Results ER: Pending PR: Pending HER2: Negative by IHC Performed on Case: Pathological staging (pTN): pT 1c N 0  Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition. CLINICAL HISTORY: Patient with breast cancer at inferior mammary crease; 2nd area of enhancement in lower breast by MRI (low suspicion). PRE-OPERATIVE DIAGNOSIS: Right breast cancer INTRAOPERATIVE CONSULTATION: FSA1-FSA2: Subareolar tissue right breast- Normal breast tissue. No tumor seen. Diagnosis called to Dr. at by Dr.. TPB1-TPB2-TPC-TPD-TPE: SLN #1-2-3-4 right axilla: Negative for tumor. Diagnosis called to Dr. at by Dr.. F. Right breast- Gross examination: 2cm mass, 0.2cm from deep margin. Fibrotic area at subareolar region. No definite mass. Diagnosis called to Dr. at. by Dr.. ADDENDUM: SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimen: Surgical Excision Block Number: F9 ER: Negative Allred Score: 0 = Proportion Score 0 + Intensity Score 0 PR: Negative Allred Score:  0 = Proportion Score 0 + Intensity Score 0 COMMENT: The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring range from O to 8. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2. METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Immunohistochemistry was performed usinn the mouse anti-human ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) provided by following the manufacturer s instructions. This assay was not modified. interpretauon di tne ER/PR immunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal review of staining performance. Gross Dictation:, Microscopic/Diagnostic Dictation: Final Review: Pathologist, Final: Pathologist,
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+--- Page 4 ---
+TSS: Addendum: Pathologist, Addendum Final: Pathoiugist,
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diff --git a/output/text/b71b7447-f04c-4ac5-887f-cfd1c655ef31.txt b/output/text/b71b7447-f04c-4ac5-887f-cfd1c655ef31.txt
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index 0000000000000000000000000000000000000000..9642ba8f80893d9dd21a6907943ba6ba665ed95b
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+IC D-O 3 UUID:FEE2A033-7EE5-4528-80AF-979BD2FDCBF9 L/sS TCGA-A6-A56B-01A-PR Aoanssssssnsno Redacted 8/40/3 Site: Len, siemoiol C18.7 SURGICAL PATHOLOGY REPORT SPECIMEN A.  Sigmoid colon B. Distal margin CLINICAL NOTES GROSS DESCRIPTION A. Received fresh, then fixed in formalin, labeled "sigmoid colon", is an 18 cm. long portion of colon, opened at one end (inked blue) and stapled at the opposite end (inked black). The specimen is partially covered with pink-tan, smooth and. glistening serosa.. Externally, there is a focus of adhesions, 4 x 3 cm., located 3.5 cm. from the nearest luminal margin (inked black).. The mucosa is pink. tan, smooth and glistening, with normal to abundant folds, and average circumference of 6 cm. There is a 4 x 3.5 cm. ulcerated tumor, 3.5 cm. from the nearest luminal margin (inked black), and contiguous with the focus of serosal adhesions. This focus of adhesion is inked blue. The tumor shows gross invasion into the muscularis propria, and appears to penetrate through the fat, to within 0.3 cm. of the surgical margin of the adhesion. The focus of the radial margin is grossly unremarkable. The remainder of the mucosa is pink-tan, smooth and glistening, with. two polypoid lesions, 0.3 cm. in greatest dimension, located within 2 cm. of the black inked margin and 5.5 cm. of the blue inked. margin. These show no gross invasion. Lymph nodes are identified. in the fat. Representative sections of the specimen are submitted as. follows: BLOCk suMMARy: 1 - Representative luminal margins; 2 - polyps, full thickness; 3-5 - representative sections of tumor, including representative to normal and representative to surgical margin; 6 - six possible lymph nodes, with representative cross sections of vasculature; 7 - nine lymph nodes; 8 - seven lymph nodes; 9 - three lymph nodes. RS-9 B. Received in formalin, labeled "distal margin", is a 1.5 cm. long portion of annular tissue, which is stapled at one end and opened at the opposite end. The staples are irregular. The staples are removed and the remainder of the specimen is entirely submitted in one cassette. As-1 MICROSCOPIC DESCRIPTION Histologic type: Adenocarcinoma (Sigmoid colon). Histologic grade: Moderately-differentiated. Primary tumor:  carcinoma penetrates through muscularis propria, but does not reach serosal surface (pT3). Margins (Proximal, Distal, Radial): Negative. Distance of tumor from closest margin: 1.5 cm (radial) Vascular invasion: Not identified.  Immunostains for CD34, CD31, and desmin performed to exclude large vessel invasion, along with an elastic stain.  Regional lymph nodes (pNl): Carcinoma present in 3 of 25 lymph nodes (3/25). Non-lymph node pericolonic tumor: Not identified.
+
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+Other findings: Hyperplastic polyps (2). Comment: portions of this case (lymph nodes) were reviewed with [A few of the antibodies used in our laboratory may be classified as analyte specific reagents. These antibodies are monitored and controlled in our laboratory and their performance for in vitro not been cleared or approved by the FDA.]. DIAGNOSIS A. Colon, Sigmoid, Segmental resection: Adenocarcinoma, moderately-differentiated.. Carcinoma penetrates through muscularis propria, but does not reach the serosal surface.. Margins of excision negative.. Carcinoma is present in three of twenty-five lymph nodes (3/25). B. Colon, Distal Margin, Segmental Resection: No malignancy identified. End Of Report
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diff --git a/output/text/b722fd97-fda9-45c3-ab90-348a7483c742.txt b/output/text/b722fd97-fda9-45c3-ab90-348a7483c742.txt
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index 0000000000000000000000000000000000000000..0c43df37784653f3b01ed67291792aa38d36c40e
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+TSS IC TSS ID: Oc ID: Date of Procurement. Gross Description:  Lump with the tumor of 2.5 x 2.2 cm in size; fatty tissue lymph nodes demonstrate lipomatosis, hyperemia.. Microscopic Description: Infiltrating duct carcinoma, G2. Ten dissected lymph nodes demonstrate sinus histeocytosis.. Diagnosis Details: Tumor Features: Unknown, Tumor Extent: T2 tumor size more than 2cm not more than 5 cm, Venous Invasion: Absent, Margins: Absent, Treatment Effect: Comments:e 1es-0-3 Formatted Path Report: cavcin onx,infiltrat;yy ouct,N0s 85ro/3 BREAST TISSUE CHECKLIST Sits: brest, NOs 50.9 4/8/11 Specimen type: Lumpectomy Specimen size: Not specified Tumor site: Upper outer quadrant Tumor size: 2.2 x 0 x 2.5 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinoma Histologic grade: Moderately differentiated Tumor extent: Not specified  Lymph nodes: 0/10 positive for metastasis (Axillary 0/10) Extracapsular invasion of the lymph nodes: Not specified. UUID: 8A865E33-082A-4S4F-A6DF-89E994206E65 TCGA-E9-A1R6-01A-PR Redacted Margins: Uninvolved Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified 8/11
+
+--- Page 2 ---
+TSS ID.... Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified. Comments: None Laterality: Right, upper outer quadrant.
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diff --git a/output/text/b733ce2a-c7b0-4724-af1b-b3f3b8f66478.txt b/output/text/b733ce2a-c7b0-4724-af1b-b3f3b8f66478.txt
new file mode 100644
index 0000000000000000000000000000000000000000..478d913fc8a7593fb27b6e9f842f33722e26950e
--- /dev/null
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+--- Page 1 ---
+UUID:754BC231-6859-478C-8874-66CB06F2596C TCGA-GV-A3JX-01A-PR Redacted SURGICAL PATHOLOGY REPORT De-Identified Specimen Code Patient Age/Sex I M SPECImeN SUBMITTED: Part A: LEFt DIStAL UReTer Part B: RIGhT DISTAL UreTeR Part C: BLADDER/ PROSTATE Part D: RIGHT PELVIC LYMPH NODES Part E: LEFT PELVIC LYMPH NODES Final Dlagnosis 1. Left and right distal ureters, biopsy (A, B) - Negative for neoplasm. 2. Bladder, excision (C)- Invasive poorly differentiated urothelial carcinoma with invasion through muscular wall and involvement of perivesical adipose tissue. 3. Prostate, excision (C) - Glandular hyperplasia. -Chronic inflammation. 4. Seminal vesicles, right and left, excision (C) - Negative for neoplasm. 5. Right pelvic lymph nodes, excision (D) - Negative for neoplasm, ten lymph nodes. 6. Left pelvic lymph nodes, excision (E) - Negative for neoplasm, ten lymph nodes. 1cs-0-3 8/20/3 Catcin`om+. nrotheli! NOs Siti: b1addiv.nos C47.9 h Page 1 of 3
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT Diagnosis Comment: 2. Specimen Type: Radical cystoprostatectomy Tumor Size, Greatest dimension: 3.0 cm.  Histologic Type: Urothelial carcinoma with glandular and squamous differentiation. Urothelial Carcinoma: (WHO/ISUP, 1998) High-grade Associated Epithelial Lesions: High-grade papillary urothelial carcinoma in previous biopsy specimen Margins:  Margins uninvolved by invasive cancer. Venous/Lymphatic (Large/Small Vessel) Invasion (V/L): Absent Direct Extension of Invasive Tumor: Perivesical fat Other Diagnoses: See above Pathologic Stage: Primary Tumor: (pT) pT3b: Macroscopically invades perivesical fat (extravesical mass) Regional Lymph Nodes: (pN) pNO: No regional lymph node metastasis Distant Metastasis (pM): pMX: Cannot be assessed Clinical Diagnosis: BLADDER CA Page 2 of 3
+
+--- Page 3 ---
+SURGICAL PATHOLOGY REPORT Gross Description: A. Received fresh at the frozen desk is a specimen labeled "left distal ureter" consisting of one piece of Iuminal tissue measuring 1 x 1 x 0.5 cm. The specimen is unoriented. The specimen is bisected and totally submitted for frozen section as A1.. B. Received fresh at the frozen desk is a specimen labeled *right distal ureter" consisting of one piece of unoriented luminal tissue measuring 1 x 0.5 x 0.5 cm. The specimen is bisected and totally. submitted for frozen section as B1.. C. Received in formalin labeled "bladder and prostate" is a specimen consisting of a urinary bladder with attached prostate and seminal vesicles. The bladder measures 11 x 10 x 4 cm. The exterior surface of the bladder is covered by fibroadipose tissue and is inked black. After the bladder is opened, a polypoid mass measuring 0.7 x 0.6 x 0.6 cm is identified in the left posterior inferior wall of the bladder 0.2 cm from the left ureter. On sectioning, the mass extends through the muscularis into the surrounding adipose tissue but appears to be 0.4 cm from soft tissue margin (inked black). The tumor portion involving the bladder wall has the following dimensions: 3 x 1.5 x 1.5 cm. The remaining bladder mucosa is slightly edematous. A segment of right ureter is 1 cm. It is patent with unremarkable mucosa. A segment of left ureter is 1 cm. Its mucosa is roughened, but it is patent. The prostate measures 3.5 cm transversely, 3 cm anteroposteriorly, and 3 cm craniocaudally. The capsular surface is smooth. The gland is inked blue on the right, and yellow on the left. The gland is sectioned from apex to base transversely at 3 mm intervals perpendicular to the urethra. The cross sections do not reveal a mass lesion. Rubbery nodularity is not present. The seminal vesicles are unremarkable. Sections are submitted as follows: C1 right ureteric margin, C2 left ureteric margin, C3 urethral margin, C4 tumor with deepest extension, C5-C8 tumor involving bladder wall, C9 left ureter, C10 right ureter, C11 posterior bladder wall, C12 right bladder wall, C13 left bladder wall, C14 bladder dome, C15 bladder trigone, C16 right apex of the prostate, C17 left apex of the prostate, C18 right mid portion of the prostate at 9 mm, C19 left mid portion of the prostate at 9 mm, C20 right base of the prostate with right seminal vesicle, C21 left base of the prostate, C22 left seminal vesicle, C23 anterior bladder wall.. D. Received fresh labeled "right pelvic Jymph node" are multiple irregular segments of fibroadipose  tissue aggregating to 6.0 x 4.0 x 1.0 cm. Palpation reveals 10 tan-pink firm nodules resembling lymph. nodes ranging in size from 0.7 to 5.0 cm in greatest dimension. The nodules are totally submitted in formalin as follows: D1 two nodules; D2 two nodules; D3 two nodules; D4 two nodules; D5 one nodule; D6-D9 largest nodule, serially sectioned, totally submitted. E. Received fresh labeled "left pelvic lymph nodes" are multiple irregular segments of fibroadipose tissue aggregating to 6.0 x 5.5 x 1.5 cm. Palpation reveals 17 tan-pink firm nodules resembling lymph nodes ranging in size from 0.2 to 6.0 cm in greatest dimension. The nodules are totally submitted in formalin as follows: E1 four nodules; E2 four nodules; E3 four nodules; E4 two nodules; E5 one nodule bisected, totally submitted; E6 one nodule; E7-E11 largest nodule, sectioned, totally submitted. Page 3 of 3
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new file mode 100644
index 0000000000000000000000000000000000000000..b312162db3572a04d6192fec6280eaebca021264
--- /dev/null
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+
+--- Page 1 ---
+SURGICAL PATHOLOGY REPORT Clinical Diagnosis & History:. with right colon cancer. No neoadjuvant chemoradiation. Specimens Submitted:. 1: Sp: Colon, right, colectomy 2: SP: Liver biopsy segment three. 3: Sp: Left fallopian tube and ovary 4: sp: Right fallopian tube and ovary DIAGNOSIS: 1. Sp: Colon, xight, colectomy: Tumor Type: Adenocarcinoma Histologic Gxade: Moderately differentiated Tunor Location: Cecun Tumor Size: Length ig 6.8 cm. Width is 5.8 cm Maximal thickness is 1.5 cm Tumor Budding: Focal Increased Tumor Intiltrating Lymphocytes: Absent Precursor Lesione: Tubular adenoma Deepest Tumor Invasion: Subserosal adipose tissue and/or mesenteric fat Gross Tumor Perforation: Not identified Lymphovascular Invasion:. Not identified Large Venous Invasion: Not Identified Perineural Invasion:. Not identified Surgical Margins: Free of tumor Polyps/Mucosa Dysplasia (away from the carcinoma): * Continued on next page **
+
+--- Page 2 ---
+Not Identified Non-Neoplastic Bowel: Unremarkable Appendix: involved by adenocarcinoma Lymph Nodes: Number with metastaais: 0 Total number examined: 21 Tumar deposits in pericolorectal soft tissue: Not Identified Tumor Staging ( (AJCc 7th Edition) : pT3 (Tunor invades through the muscularis propria inta pericolorectal tissues) Lymph Node Stage (AJcc 7th Edition): NO (No regional lymph node metastasis) 2. LIVER, SEGMENT III, BIOPSY: -BENIGN LIVER PARENCHYMA AND VESSELS. 3. FALLOPIAN TUBE AND OVARY, LEFT, RESECTION: -BENIGN FALLOPIAN TUBE AND OVARY. FALLOPIAN TUBE AND OVARY, RIGHT, RESECTION: -BENIGN FALLOPIAN TUBE AND OVARY. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. 1) The specimen is received fresh, labeled "Right colon" and consists of a segment of terminal ileum, cecum with attached appendix and ascending colon. The terminal ilewm measures 3.5 cm in length and 4 cm in circumference at the proximal resected margin. The remaining colon measures 28 cm in length with a circumference of 8 cm at the distal resected margin. The attached appendix measures 5 cm in Iength and measures 0.4 cm in diameter at its distal end; however dilated to 2.5 cm at the proximal end. The appendiceal and intestinal serosa is pink tan and smooth. Focally hemorrhagic lohulated yellow tan adipose tissue spans the length of the specimen measuring up to 1 cm in thickness.  The specimen is apened to reveal an exophytic mass lesion measuring 6.8 x 5.8 x 1.5 cm. The mass is centered in the appendiceal Orifice, 3.5 cm from the proximal margin and 23 cm from the distal margin. Sectioning shows that the tunor invades through muscularis propria to the serosal surface. The depth of invasion is 1.2 cm grosaly. The remaining ** Continued on next page **
+
+--- Page 3 ---
+ Page 3 of 5 mucosa is unremarkable. The attached adipose tissue is thoroughly examined and all identified lymph nodes are submitted. Representative sections of the specimen are submitted for permanent sections and for Tps. Sumnary of sections: P - proximal margin shave.  distal margin shave - appendix from distal to proximal including its orifice involved by the tumor TCE - tumox (cecun) rCO tumor (colon) TIC- tumor (ileocecal valve) LN - lymph nodes 2). The specimen is received in formalin, labeled "Liver biopsy segment. three" and consists of two tan-brown fragments of soft tissue measuring 0.8x 0.3 x 0.2 cm and 2.0 x 1.0 x 0.7 cm. The larger wedge shaped fragment is. Inked at the surgical margin and bisected. The entire specimen is submitted. Summary of sections: L--larger tissue S--smaller tissue 3). The specimen is received in formalin, labeled "Left fallopian tube and ovary" and consists of a fallopian tube with attached ovary.. The fallopian tube measures 4.5 cm in length and averages 0.5 cm in diameter.. The external surface of the tube is pink tan and smooth with a normal fimbriated end, multiple paratubal cyste are identified averaging 0.l cm. Cut section through the tube reveals a pinpoint lumen. The attached ovary weighs 2.5 g. and measures 2.5 x 1.0 x 0.8 cm. The external surface is yellow.and smooth.. Cut section through the ovary reveals yellow-white ovarlan stroma. No. discrete lesions are grossly identified. Representative sections are submitted. Summary of sections: - fallopian tube 0 - ovary 4). The specimen is received in formalin, labeled "Right fallopian tube and ovary" and consists of a fallopian tube with attached ovary. The fallopian tube measures 4.5 cm in length and averages 0.5 cm in dianeter. The external surface of the tube is pink tan and smooth with a normal fimbriated end. Paratubal cysts are identified averaging 0.2 cm. Cut section through the tube reveals a pinpoint lunen. The attached ovary weighs 2.5 g and. measures 3.1 x 1.5  x 1.3 cm. The external surface is yellow and smooth Cut section through the ovary reveals yellow-white ovarian stroma. Representative sections are aubmitted. * Continued on next page.
+
+--- Page 4 ---
+Page 4 of 5 Summary of sections: r - fallopian tube  - ovary Sunmary of Sections:. Part 1: Block Sect. site PC 4 3 7 LN 21 rt N 1 tce tco 2 NN 2 tic Part 2: SP: Liver biopsy segment three Block Sect. site PCg 1 L 2 1 9 1. Part 3:  SP: Left fallopian tube and ovary Block Sect. Site PCg 2 F m N 2 0 Part 4: Sp: Right fallopian tube and ovary. Block Sect. Site PCs r 4 N 0 3 Addendum Diagnosis THE IMMUNOHISTOCHEMICAL STAINING FOR THE TESTED DNA MISMATCH REPAIR PROTEINS (MLH1, MSH2, MSH6 AND PMS2) IS RETAINED IN THE TUMOR. ** Continued on next page ** :
+
+--- Page 5 ---
+** End of Report *
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diff --git a/output/text/b74f3662-6180-433c-a9e2-2df031815b9b.txt b/output/text/b74f3662-6180-433c-a9e2-2df031815b9b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..cc536e9851acc08016af3438f78d883932a0e4f2
--- /dev/null
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+
+--- Page 1 ---
+Diagnosis: 1. and 3. Right hemicolectomy preparation with tumor-free oral and aboral resection. margins and including an ulcerated, moderately differentiated double carcinoma of the colon (ascending colon pT4 L1 V0 R0 and left flexure pT3 L1 V0 R0) with two local. lymph node metastases (pN1b 3/41) (1.) and with hepatic spread (pM1a (3.).
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diff --git a/output/text/b767b922-e38f-45dc-95ac-cf78f2dfff22.txt b/output/text/b767b922-e38f-45dc-95ac-cf78f2dfff22.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a99b4d89b55082df71a1225098892fb28fb316e6
--- /dev/null
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+
+--- Page 1 ---
+1cs-0 - 3 Cavcinonn,mifiAtratiry duct,Nv5 850cJ Sir: brast, Nos c5o.9 h 4fs3{11 OC# TSS # Procurement Date:3/10/2011 Laterality:Left, upper outer quadrant Path Report:BREAST TISSUE CHECKLIST Specimen type: Lumpectomy Specimen size: Not specified Tumor site: Upper outer quadrant Tumor size: 2 x 0 x 2.5 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinoma Histologic grade: Moderately differentiated Tumor extent: Not specified Lymph nodes: 0/10 positive for metastasis (Axillary 0/10) Extracapsular invasion of the lymph nodes: Not specified Margins: Uninvolved Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined. Evidence of neo-adjuvant treatment: Not specified. Additional pathologic findings: Not specified UUID:6272ED78-501A-4055-8C87-430F46F518AA Comments: None TCGA-E9-A249-01A-PR Redacted
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diff --git a/output/text/b7776d6f-67c6-4a3e-98ba-47e3a0aab795.txt b/output/text/b7776d6f-67c6-4a3e-98ba-47e3a0aab795.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d9e6cbb69d2ac4b5de4852a5ab3cb9a9fa387a13
--- /dev/null
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+
+--- Page 1 ---
+TCGA #:  Internal Sample ID: Diagnosis: This is an invasive adenocarcinoma in the region of the liver.. This finding is certainly compatible with a metastasis from adenocarcinoma of the colon.. Diagnosis: This is a moderately differentiated adenocarcinoma of the colon (G2) with infiltration of all parietal layers (pT3), with lymph vessel and blood vessel invasion (L1, V1) and with four sections of lymph node metastases (pN1), and also - in relation to the ligature and resection margins - free resection margins. Tumor classification: ICDO-DA-M 8140/3 G2 pT3, L1, V1, pN1, MX 1CD-O -3 adno ca^ciomn,Nos 8/4o/3 Sit: cocum fow c9cF) c18.opw 3/3o/s UUID:72783514-8591-4698-B5CE-863E274A521C0 TCGA-AA-A02E-01A-PR Redacted
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diff --git a/output/text/b78a357d-7080-4bcd-b0d2-46b558f4a69f.txt b/output/text/b78a357d-7080-4bcd-b0d2-46b558f4a69f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7b4b535dc9c8daaec03123d921f453c8e61f31f5
--- /dev/null
+++ b/output/text/b78a357d-7080-4bcd-b0d2-46b558f4a69f.txt
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+
+--- Page 1 ---
+Sample Diagnosis: 1.: Subcapsular portion of the liver parenchyma with von Meyenburg's complex moderately developed fatty infiltration of the parenchyma.. 2.: Resectate of a portion of the colon (sigmoid colon) with a tubulovillous colonic mucosal adenoma, extending no closer than 4.5 cm to a resection margin and measuring 1.8 cm at its greatest diameter, with severe epithelial dysplasia (synonym: high-grade intra-epithelial neoplasia) and with transitions into a moderately differentiated. adenocarcinoma of the colorectal type, or colon carcinoma, fully circumferential and continuing into the internal portions of the submucosa.. Oral and aboral resection margins tumor-free.. Seventeen mesocolic lymph nodes tumor-free with uncharacteristic reactive changes. Tumor stage therefore pT1 pN0 (0/17) L0 V0; G2 R0. /cs-0- 3 Redacted Qdenocuciioma, N0s 814o/3 Iit: pigmrid con C18.1 4/
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diff --git a/output/text/b7b62570-ebb0-4da8-b2b5-331464ce01e6.txt b/output/text/b7b62570-ebb0-4da8-b2b5-331464ce01e6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f3caf5d73c71e2a3b30cd36aef429773429306bb
--- /dev/null
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+
+--- Page 1 ---
+3697-46E7-96E6-1CDAAE63DFC5 Redacted Histopathology Histopathology XE IcD o:3 arenon,wrelesQ NOS 8/xof3 Specimen Comments SPECIMEN arsncmstranstinal celQ.NsS 8i2OJ3 Bladder and prostate. S.ite.: Madsler Nos C47.9 2 - Right obturator. 3 - Right external ileac. RO 4/3i>|i4 4 - Left distal ureteric margin.. 5 - Right distal ureteric margin.. CLINICAL DETAILS Bladder cancer. Clinically involved obturator nodes right, cystectomy & right lymphadenectomy. MACROSCOPY 1 - Cysto-prostatectomy specimen measuring 125 mm supero-inferiorly x 110 mm medio-lateral x 65 mm antero-posteriorly. The prostate measures 30 mm superior to inferior and 45 mm medial to lateral. On sectioning there is a tumour situated on the right side. The tumour abuts the perivesical fat and measures 20 mm x 6 mm. The background mucosa appears haemorrhagic and possibly abnormal. The prostate shows nodularity with the most prominent nodule extending towards bladder urethral orifice. The seminal vesicles appear spared by tumour, as well as the prostate. 2 - A piece of fibrous tissue measuring 55 x 38 x 22 mm. Sectioning shows 2 lymph nodes, the larger 40 mm in maximum dimension. Both nodes appear infiltrated by tumour. 3 - A piece of fibrofatty tissue 48 x 20 x 8 mm. 4 lymph nodes are identified, the largest 8 mm in maximum dimension.. 4 - A piece of ureter 7 mm long. All embedded.. 5 - A piece of ureter 10 mm long. All embedded.. MICROSCOPY Specimens 1, 2, 3, 4 & 5 The sections of the bladder show grade 3 transitional cell carcinoma that extends into the perivesical fat. Perineural and vascular are present. The ureteric, urethral and soft tissue margins are clear. The prostate shows areas of granulomatous inflammation which would be in keeping with BCG treatment. The background urothelium is reactive but no carcinoma in situ is identified. 6 lymph nodes have been identified. 2 right obturator nodes contain metastatic tumour while 4 right external iliac nodes are negative. SUMMARY Cystoprostatectomy with right obturator and external iliac nodes - completely excised grade 3 transitional cell carcinoma, with 2 positive right obturator 1ymph nodes; G3, pT3a, N2, Mx Ref: Pathologists - (Be6 compltd prior.
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diff --git a/output/text/b7bd5c4f-22d9-45d2-bc37-7c98600b795d.txt b/output/text/b7bd5c4f-22d9-45d2-bc37-7c98600b795d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..703b71517afdd3870ed5f990c0f107ecaed88fe5
--- /dev/null
+++ b/output/text/b7bd5c4f-22d9-45d2-bc37-7c98600b795d.txt
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+
+--- Page 1 ---
+ICD O-3 Tuinor Ad reral CorHciJ oFaakncw n UUID:A3E8E475-D5A7-4A4C-AA1D-3B3AE50F5728 TCGA-OR-A5L2-01A-PR Redacted uncerttin benavior   8370/1 Site: Adreuxl Elard,CorteL C7y.D Q o/b/13 Procedure: L adrenalectomy, pararenal adipose tissue Gross description: 18 x 9.5 x 5.5cm, 403g Diagnosis: adrenocortical carcinoma, mitotic rate 6 per 10 hpf Reference Pathology: none. Pu NcI cucmy ship as Lwq as i+is ACC(Ngnd|ess g Sthtu bihamor). Ber Pws s if ess Jus. wu urll Mquf m+u pith = iMey nit shipit N h y4/e3
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diff --git a/output/text/b7bfabf4-b704-4f7a-9758-43fc13372a12.txt b/output/text/b7bfabf4-b704-4f7a-9758-43fc13372a12.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4edeb95b1305c81d0e374a6fa5e03365ba8bca50
--- /dev/null
+++ b/output/text/b7bfabf4-b704-4f7a-9758-43fc13372a12.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+Referring Physician: Dob: * Age: Gender:F Ref#: Hosp#: Provider Group : UUID:1A0D203A-BC4B-441F-97F6-D1FF7E959262 Redacted Date of Service: Date Received: Outpatient Room: Bed: FINAL SURGICAL PATHOLOGY REPORT Diagnosis: A. , C, D.) RIGHT BREASt AND AXIlLARy SENTINEL LyMPH NODE, MASteCTOMy AnD SEnTInel Lymph NODE biOPSy: - Multicentric invasive lobular carcinoma, Nottingham grade 1-2.. - The area involved by invasive carcinoma measures approximately 8 cm in. diameter. - See comment. - Two axillary lymph nodes, no tumor present (0/2).. - This includes one sentinel Iymph node and one non-sentinel lymph node.. - Resection margins are free of tumor. Invasive carcinoma is at least 1 cm. from all margins. The closest margin is the inferior, which is approximately 1 cm from carcinoma. - Lobular carcinoma in situ (LCiS), classic type, low nuclear grade, widespread throughout the right breast. - Sites of previous biopsy identified. PATHOLOGIC TUMOR STAGING SYNOPSIS: Type and grade (invasive): Invasive lobular carcinoma, Nottingham grade 1.. Type and grade (in situ ): Lobular carcinoma in situ, low nuclear grade.. Primary tumor: pT3(m) Regional Iymph nodes: pNo(i-)(sn). 1cd-o3 carcrnomg Jobwsgr, inhiHatinc Distant metastasis: Not applicable. 8 5q0|3 Pathologic stage: IIB. Lymphovascular invasion: Not identified.. Si+: br<ast,nos cS0.9 Margin status: Negative (R0). 4-3-1 COmMENT: In addition to the two areas of invasive lobular carcinoma previously biopsied, there is a large area of invasive lobular carcinoma in roughly the center of the breast that corresponds to the abnormal area detected in the right breast MRI. dated I (the suspicious area measured 8.1 cm in diameter on MRl). Grossly,. this was an ill-defined area relatively denser than the surrounding breast tissue.. B. LEft BrEaSt, pROphylAcTIC masTecTOmy: Case #: Page 1 Printed: This renort ... (finaL) Phone: Patient Nam . Page 1 Pathology Report - Page 1/6 J
+
+--- Page 2 ---
+Case #: FinAL SurGICAL PAtHOLOgy rEPOrt - Focal atypical ductal hyperplasia (ADH, in lower outer quadrant) - Subareolar duct ectasia.. - Focal fibrosis, cysts and mild usual type ductal hyperplasia. - Discrete focus of scar tissue in central inferior breast. Breast Invasive Tumor Staging Information. , and CAP protocoi, (AJCC Cancer Staging Handbook.e This staging also incorporates:. Previous biopsy: Breast profile: Page 2 Case #: This report continues... (FiNAL) Printed: Acct No. : Patient Narr Page 2 Pathology Report - Page 2/6
+
+--- Page 3 ---
+Case #: Specimen type: Total breast. Mastectomy. Specimen procedure: Lymph node sampling: Sentinel lymph node. Specimen integrity: Intact specimen. Right. Specimen laterality: Specimen size: 24.4 x 21.8  6.4 cm. INVASIVE TUMOR FEATURES: Invasive tumor size: Approximately 8 cm in diameter Invasive tumor site: Central, in addition to areas previously biopsied (12:00 and 9:30 aspects of right breast). Invasive tumor focality: Multicentric Histologic type: Invasive lobular carcinoma. Total Nottingham Grade: 1 of 3. Tubule formation: 3 of 3. Nuclear Pleomorphism: 1-2 of 3. Mitotic count for Nottingham: 1 of 3. 1 mitosis in 10 high power fields. Mitotic count: Not identified. Lymphatic invasion: MARGIN STATUS FOR INVASIVE COMPONENT: Negative. Distance of tumor from margins: Approximately 1 cm. Closest margin: Inferior Other margins: All other margins at least 1 cm from tumor. DUCTAL CARCINOMA IN-SITU (DCIS): Absent. LOBULAR CARCINOMA IN-SITU (LCIS):A Present, extensive. Skin: Unremarkable. Nipple: Focal subareolar duct ectasia. Subareolar foci of invasive lobular carcinoma present. Skeletal Muscle: Not applicable. INVASIVE PATHOLOGIC TUMOR STAGING (pTNM) Primary tumor (pT): pT3 Regional lymph nodes (pN): pN0(i-)(sn). Distant metastasis (pM): Not applicable. Tumor Stage: 118 RECEPTOR STATUS AND HER2/NEU: Biomarkers performed on. two separate core needle biopsies. Estrogen receptors: 95%. Progesterone receptors: 80% and 50%, respectively. Her2/neu: 1+ Page 3 Case #: ntin..es .. (FINAL) Printed: Phone Acct N< Patient Nam - Page 3 Pathology Report - Page 3/6
+
+--- Page 4 ---
+ Datiant. Case #: FINAL SURGICAL PATHOLOGY REPORT 1-2%. Ki-67 proliferative index: Signed oy Source of Specimen: A. Sentinel lymph node;Sentinel node #1, Right breast B.BreastLeft C. Breast;Right breast-additional inferior margin D. Breast;Right Clinical History/Operative Dx: Neoplasm of right breast. Intraoperative Diagnosis: A. Sentinel node #1 right breast touch prep A diagnosis: Negative for carcinoma. (Dr. The intraoperative interpretation(s) was/were performed and rendered at *. Gross Description: A. The specimen is labeled sentinel node #1 right breast. and is received without fixative. It consists of a 0.5 x 0.5 x 0.4 cm lymph node. It is serially sectioned and touch imprints are obtained. The node is submitted for permanent section in cassette A1. . B. The specimen is labeled left breast tissue and is received in formalin. It consists of a mastectomy specimen which weighs 1,258 grams. A black suture marks lateral. With this orientation, the specimen Page 4 Case #: This report continues... (FINAL) Printed: Phone: MR No. Acct No. - Patient Narr ) - Page 4 Pathology Report - Page 4/6
+
+--- Page 5 ---
+Case #: FInAL SURGICAL PATHOLOGy REPORT measures 20.5 cm from superior to inferior, 29 cm from medial to lateral, and 4.5 cm from superficial to deep. There is a broad overtying semi-circular portion of tan skin measuring 23 x 14.5 cm. In the media! inferior edge of the skin, there is a 4.5 cm areola with a protuberant 1.4 cm nipple. The skin is otherwise unremarkable. The anterior-superior margin is inked blue, the anterior-inferior margin is inked green, and the posterior margin, which partially consists of smooth facial appearing tissue, is inked black. The specimen is serially sectioned at close intervals to reveal Iobulated fatty tissue and scattered tan-white ribrous parenchyma. In the central inferior portion of the breast, along the superior medial edge of the areola, there is an area of fibrous parenchyma which has a slightly stellate appearance but is soft and rubbery. This stellate area is 2 cm in maximum dimension. it is 4 cm or greater from the deep, inferior, and superior margin and is 2 cm from the closest skin. The breast parenchyma in the lower outer quadrant. has a rough fine nodular feel but there are no areas which have a stellate or retracted appearance. There are no lymph nodes identified within the lateral portion of the excision. Representative sections are submitted.Section summary: B1) nipple and tissue just deep to nipple, B2-B3) stellate fibrous parenchyma centra! inferior breast, 84) representative upper inner quadrant, B5) lower inner quadrant, 86) upper outer quadrant, B7-B8) lower outer quadrant, including representative lower outer quadrant deep margin. C. The specimen is labeled right breast tissue, additional inferior margin and is received in formalin. It consists of two irregular fragments of lobulated fatty tissue with an aggregate weight of 52 grams. The larger specimen measures 10.5 x 4.8 x 1.6 cm and the smaller specimen measures 4.2 x 2.8 x 1.7 cm. The surgical margins of these specimens are not designated. The larger specimen is inked black and the smaller specimen is inked green. Serial sections of both specimens reveal predominantly lobulated soft to. pale yellow fatty tissue without palpable areas of nodularity. Representative sections of the larger specimen are submitted in cassettes C1-C3. Representative sections of the smaller specimen are submitted in cassette C4. Following review of the initial slides, additional sections are submitted in Cs-C9. D. The specimen is labeled right breast tissue and is received without fixative. It consists of a mastectomy. specimen weighing 1,285 grams. A black suture is present and is not otherwise designated but is arbitrarily assumed to represent lateral. With this orientation, the specimen measures 24.4 cm from medial to lateral, 21.8 cm from superior to inferior, and 6.4 cm from superficial to deep. There is an overlying broad elliptical portion of tan skin which measures 24 x 16 cm. In the medial inferior skin, there is a 4 cm areola and 1.5 cm protuberant nipple. The skin shows two small areas of hemorrhagic discoloration which are Iocated 3 and 3.5 cm superior to the nipple. No other skin lesions are identified. The anterior-superior margin is inked blue, the anterior- inferior margin is inked green, and the posterior margin, which consists partially of smooth facial tissue, is inked black. The breast is serially sectioned at close intervals to reveal a firm stellate appearing tumor mass within the central Iateral breast, approximately 4.5 cm lateral to the nippie. This stellate area is 1.2 cm in maximum dimension. Centrally, within this stellate mass is a biopsy site clip. This stellate mass is 3.5 cm from the closest inferior margin, 11 cm from the closest superior margin, 14 cm from the closest medial margin, and 11 cm from the closest lateral margin. It is 3.5 cm from the closest deep margin and approximately 3 cm Page 5 Case #: This reoort continues... (FINAL) Printed: Phone: Patient Nan ) - Page 5 Pathology Report - Page 5/6
+
+--- Page 6 ---
+Case #: FINAL SURGICAL PATHOLOGY REPORT from the skin. A second palpably firm and stellate appearing mass is located in the superior central breast approximately 4 cm superior to the nipple. This second area measures 0.8 cm in maximum dimension. It is 4 cm from the closest deep margin, 3.5 cm from the closest skin, 6.5 cm from the closest inferior margin, 9 cm from the closest superior margin. 10 cm from the closest medial margin, and greater than 10 cm from the lateral margin. A twisted biopsy site clip is also embedded within this stellate mass.. The central breast tissue has an ill-defined firm area measuring approximately 7-8 cm in diameter. This. area of firmness involves multiple quadrants of the breast. In the far lateral portion of the breast, there is a firm 1.8 cm lymph node. Representative tissue of the central lateral stellate mass is retained for research purposes. Representative sections are submitted. Section summary: D1) nipple and tissue just deep to nipple, D2-O3) complete cross-section of central lateral palpable mass,. D4) additional section of superior edge of central lateral tumor,. D5-D6) sections of central superior tumor mass (biopsy site clip in cassette D5),. D7) central superior deep margin,. D8) central lateral deep margin, D9) representative upper inner quadrant, D10) representative medial lower inner quadrant,. D11) representative lateral lower inner quadrant,. D12) representative lateral lower inner quadrant and closest anterior inferior margin.. D13) upper outer quadrant, D14) lower outer quadrant, D15-D16) lymph node lateral portion of excision. Microscopic Description:. A. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered. Immunohistochemical stain: , showing no evidence of metastatic carcinoma.. Appropriate positive and negative controls reviewed. B. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis. rendered. C. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis. rendered. D. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis. rendered. Page 6 Case #: Enn Oe DconRt (FINAL) Printed: Phone: Acct No. - ! Patient Nar MR No. - Page 6 Pathology Report - Page 6/6
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diff --git a/output/text/b7d2466d-9629-4d0c-956c-8ba05df54574.txt b/output/text/b7d2466d-9629-4d0c-956c-8ba05df54574.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1659341145ef417ceaad6b8b92724535fa41d7e1
--- /dev/null
+++ b/output/text/b7d2466d-9629-4d0c-956c-8ba05df54574.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+Patient Name Accession #: Med. Rec. #: Date of Procedure: DOB: Date of Receipt: Gender: Date of Report: Ret. Physician: Account # Patient Address: Billing Type: Additional Copy to. Ref. Source Clnt nagis & History: Jarge right renal mnass and retroperitoneal lymphadenopathy with oulside bx showing collecting duct CA Spocimens Submitted: 1: Kidney. right, total nephrectomy. 2: Lymph nodes, interaortacaval and presacra sion 3: Lymph nodes, interaortocavat #2, excision. 4: Right adrenal gland, paracaval and retroc:. i ynph nodes, excision. 5: Lymph nodes. para-aortic, exclsion 6: Lymph nodes, right suprahilar. exci. DIAGNOSIS: 1.Kidney, right, total nophrectomy Tumor Type: Renal cell carcinoma - Unclassified lype. High grade. See comment. Tumor Size: Greatest diameter is 9.2 cm.. Local Invasion (for renal cortical types):. Extends into renal pelvis Involves renal hilar fat. Local Invasion (for renal pelvic tumors):. Involves rena! hilar fat. Renal Vein Invasion: Not identified Tumor is present within medium sized vessels in the renal hilum. Surgical Margins:. Free of tumor Non-Neoplastic Kidney: Unremarkable Adrenal Gland: Not identified Lymph Nodes: Not identified Staging for renal cell carcinoma/oncocytoma: pT3b Tumor grossly extends into the renal vein(s) or vena cava below the diaphragm. Page 10f4
+
+--- Page 2 ---
+Comment:The tumor cells are reaolive for CD10, RCC. racemase, and o-cadherin. They are negative for CK7, CK20, and  34BE12. Despite the unusual morphologic and immunohistochemical features. this is likely to represent a so-called collecting duct carcinoma. 2. Lymph nodes, interaortacaval and presacral, excisior Lymph Nodes:  Malted lymph nodes posttive for melastatic carcinoma 3.  Lymph nodos, interaortocaval #2, exclsion Lymph Nodes:.  Matled lymph nodes positive for metastatic carcinoma Right adrenal gland, paracaval and retrocaval lymph nodes, excision Adrenal gland negative tor carcinoma. Matled lymph nodes positive metastatic carcinoma. Three of eleven lymph nodes positive for metastatic carcinoma 5. Lymph nodes, para-aortic, excision Lymph Nodes: Not involved Number of nodes examined:5. 6. Lymph nodes, right suprahilar, oxcision Lymph Nodes: Not involved Number of nodes examined:10. Minute fragment of adrenat cortical lissue IATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWEO AND APPROVED THIS REPORT Special Studles:. Result Special Stain Comment CK7 CK20 348E12 CD10 RCC MUCIN E-CADHERIN NEG CONT IMM RECUT RACEMASE NEG CONT IMM RECUT CK5/6 CK8 CK18 Page 2 0f 4
+
+--- Page 3 ---
+Gross Description: 1). The specimen is received fresh labeled "right kidney tumor anu. acned ureter, renal vessels and. perinephric fat weighing 567 g in total.The kidney measures 11.4 x 9.2 x 7.5 cm.. The altached ureler measures 1.7 cm in length. and 0.4 cm in diameter. The altached renal vein measures 1.2 cm in tength and 0.3 cm in diameter. The renal vessels and ureter margins are grossly unremarkable. An adrenal gland is not identified. The kidney is inked black and bivalved lo reveal a heterogeneous mass centered in the cortex of the midsection of the kidney measuring 9.2 x 7.5 x 7.0 cm. Parts of the tumor are myxoid and galatinous, while other areas show tan-yellow leshy tissue.. The tunor extends into the capsule of the kidney and. pushes into the hilum with focal exlension into the reral pelvis.  Sections through the remainder of the kidney reveal a pink brown parenchyma, with a well-defined corticomedullary junction. The cortex measures O.9 cm and the calyces appear normal. * lymph nodes are identified in the perinephric fat. Representative sections are submitted for TPS and for permanent sections.. Summary of sections: FSC-frozen section control UVM -- ureteral and vessel margins. T.- tumor THF-- tumor with hilar fat. TSF -- tumor with sinus fat. TK -- tumor with adjacent kidney.  RP -- renal pelvis representalive sections K -- representalive sections kidney. PLN-possible lymph nodes 2). The specimen is received in formalin labeled "interaortocaval lymph nodes".  It consists of a tan soft tissue mass measuring 5.0 x 4.0 x 2.5 cm.  The cut surface shows a tan and yellow soft lissue mass with necrosis and hemorrhage. Representalive sections are submitted. Summary sections: ST-solt tissue 3). The specimen is received in formalin tabeled "interaorlocaval lymph nodes number two. It consists of a tan soft tissue. fragment measuring 4.1 x 2.5 x 2.0 cm. The specimen is sectioned to reveal a tan and yellow necrotic mass. Representative. sections are submitted. Summary of sections: ST-soft tissue 4).The specimen is received fresh labeled "right adrenal gland, paracaval and retrocaval lymph nodes". It consists of an. adrenal gland and attached soft lissue weighing 69 g and measuring 7.5 x 6.5 x 3.4 cm in overall.. The adrenal gland measures 5.8 x 4.1 x 1.0 cm. The cut surtace of the adrenal gland is grossly unremarkable.. The soft tissue is sectioned to reveal malted. grossly positive lymph nodes.  Multiple smaller lymph nodes are kdentified ranging from 1.1 to 1.5 cm in greatest dimension. Representative sections of the adrenal gland are submilted along with representative sections of the malted lymph nodes.. The smaller lymph nodes are antirely submitted. Tissue is given for TPS. Summary ol seclions: AG-adrenal gland MLN-malted lymph nodes. LN-Jymph nodes 5). It consists of fatly soft tissue measuring 3.5 x 1.5 x 1.2 cm. Multiple lymph nodes are identified ranging from 0.3 to 0.8 cm in greatest dimension. The tissue is entirely submitted.. Summary sections: LN-lymph nodes  Page 3 of 4
+
+--- Page 4 ---
+6). The specimen is received in formalin labeled "right suprahilar lymph node".  It consisls of multiple fragments of tan and fatly soft tissue measuring 3.2 x 2.0 x 1.4 cm in aggregate. Multiple lymph nodes are identified ranging from 0.3 to 0.5 cm in greatest dimension. The tissue is entirely submitted. Summary of sections: LN-lymph nodes Summary of Sections: Block Soct. Site 1 Isc 1 1 k 1 pin 1 1 rp 1 8 t 8 1 thf 1 tk 1 1 tsf 1 1 uvm 1 Part 2: Lymph nodes, Interaortacaval and presacral, oxcislo Block Sect. Site PCs 2 $1 2 Part 3: Lymph nodes, interaortocaval #2, excislo Block Sect. Site PCs 2 $t 2  Part 4:  Right adrenal gland, paracaval and retrocaval lymph nbdes, excisi. Block Sect. Site PCs 1 ag 2 m N In 3 min 2 Part 5: Lymph nodes, para-aortic, excision Block Sect. Site PC$ 2 In 2 Part 6: Lymph nodes, right suprahilar, excision Block Sect. Site PCs 2 In 2 Intraoperative Consultation: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS: RENAL CELL. CARCINOMA, CANNOT TYPE PERMANENT DIAGNOSIS: SAME Page 4 0f 4 END OF REPORT
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diff --git a/output/text/b7dc578d-4ae0-4474-ad4e-455bc93cecf9.txt b/output/text/b7dc578d-4ae0-4474-ad4e-455bc93cecf9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..67f58c8723102005c4f7fffd42ddee0da0a62c52
--- /dev/null
+++ b/output/text/b7dc578d-4ae0-4474-ad4e-455bc93cecf9.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+DiAGnosis: Kidney, right, mass, resection: Renal cell carcinoma, chromophobe type, margins of resection are free of tumor. CLINICAL INFORMATION: Brief Clinical History: right renal mass PROcEDuRe: Pre-Operative Diagnosis: rena! mass Post-Operative Diagnosis: renal. mass Operative Findings: renal mass. SPECIMENS SUBMITTED: 1. KIDNEY, RIGHT, Renal mass GROSS DESCRIPTION: Received fresh in a container labeled with the patient's name, medical record. number, and further specified as "right renal mass". The specimen is a partial nephrectomy with attached fatty tissue measuring 10.5 x 9.3 x 9.0 cm, with a kidney surface measuring 7 x 0.3 cm. The specimen is inked in black, bisected revealing tan-yellow-red cut surface. Approximately 4 x 3 x 2 cm is procured for There is also an additional piece of kidney parenchyma with attached suture. This is indicated as superior pole as per. surgeon. In Surgical Pathology, the specimen received matches the above description. Photographs are taken, and the specimen was sliced and fixed in formalin, and representative sections are submitted in white cassettes labeled : for permanent processing. The additional piece of kidney parenchyma measures 5 x 3 x 1.8 cm with a suture attached to the pelvis and ureter. The top part of the parenchyma is inked in blue and the. specinen is serially sectioned and entirely submitted in white cassettes labeled :  R for permanent processing. The procurement was performed by Gross description dictated by No consultants Page 1 of 2
+
+--- Page 2 ---
+Patient Identification Page 2 of 2
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diff --git a/output/text/b829480f-8704-4993-b996-9bfaa29610ca.txt b/output/text/b829480f-8704-4993-b996-9bfaa29610ca.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5ff4f73d68deae387d20453ac856dca08665c280
--- /dev/null
+++ b/output/text/b829480f-8704-4993-b996-9bfaa29610ca.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:FF947398-211F-4ED6-A157-B86B71988189 Patient Results TCGA-FF-A7CW-01A-PR Redacted Requested By: L HistopathologyReport Biopsy No: Final Received Date/Time Final Reporting Information Date/Time : Final Histopathologist :  Laboratory : Consultant-In-Charge Final Submitting Physician Final Histopathology Report Final DIAGNOSIS Cervical lymph node: Diffuse large B-cell lymphoma, non-germinal centre type (Hans' criteria). GROSS DESCRIPTION The specimen is received in formalin, labelled with patient's data and designated "cervical lymph node". It consists of several pieces of brownish tissue altogether measuring 2.5 x 2 x 0.6cm. (Al & A2; no reserve) MICROSCOPIC DESCRIPTION Sections of lymph node show effacement of nodal architecture by a diffuse lymphomatous infiltrate featuring sheets of large cells with vesicular chromatin and prominent central nucleoli. There are frequent mitoses, apoptotic bodies and. clusters of macrophages, thereby imparting a starry sky appearance. Immunohistochemistry confirms the B-cell iineage of the lymphomatous population, being positive for CD20. They lack expression of germinal centre markers cD10. and bcl6 (<30s) with strong expression of Muml. There is no expression of cD30 thereby excluding plasmablastic lymphoma. cd2l fails to highlight any residual follicular dendritic meshwork and there is no overexpression of cyclin Dl, which rules against pleomorphic variant mantle cell lymphoma. There is strong expression of bcl2 whilst the proliferation fraction is high at about 70% by. Ki67 immunostaining. Pathologist : ICDOr3 CewicaPQymyK msde C77.0 Sute X 8f22j13 8/4fi3 Printed from: End of Report Page: I of 1
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diff --git a/output/text/b839f54c-1dc5-42fa-9550-3b4f2ca80323.txt b/output/text/b839f54c-1dc5-42fa-9550-3b4f2ca80323.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d50a7d1ba1ed2ff70fab52d934056f6811e4d2a1
--- /dev/null
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+
+--- Page 1 ---
+SURGICAL PATHOLOGY REPORTS Clinical Diagnosis & History: Colon carcinoma. Specimens Submitted: 1: Terminal ileum, appendix, and ascending colon; Resection DIAGNOSIS: 1. Terminal ileum, appendix, and ascending colon; Resection:. Tumor Type: Adenocarcinoma Histologic Grade: Moderately differentiated. Tumor Location: Hepatic flexure Tumor Size: Length is 3.5 cm Width is 8 cm Maximal thickness is 0.6 cm. Tumor Budding: Absent Increased Tumor Infiltrating Lymphocytes:. Absent Precursor Lesions: Not identified Deepest Tumor Invasion Subserosal adipose tissue and/or mesenteric fat. Gross Tumor Perforation:. Not identified Lymphovascular Invasion:. Not identified Large Venous Invasion: Not Identified Perineural Invasion:  Not identified Surgical Margins: Free of tumor Polyps/Mucosa Dysplasia (away from the carcinoma): Tubular adenoma; number: 2 Non-Neoplastic Bowel: Unremarkable ** Continued on next page **
+
+--- Page 2 ---
+Page 2 of 3 Appendix: Unremarkable Lymph Nodes: Number with metastasis: 0 Total number examined: 20 Tumor c deposits in pericolorectal soft tissue: Not Identified Tumor Staging (AJcc 7th Edition) : pT3 (Tumor invades through the muscularis propria into pericolorectal tissues) Lymph Node Stage (AJcc 7th Edition): N0 (No regional lymph node metastasis) I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Gross Description: 1. The specimen is received fresh, labeled "Right colon" and consists of a segment of terminal ileum, cecum with attached appendix and ascending colon. The terminal ileum measures 15.2 cm in length and 4.1 cm in circumference at the proximal resected margin. The remaining colon measures 41.6ir length with a circumference of 8.2 cm at the distal resected margin. The attached appendix measures 9 cm in length and averages 0.8 cm in diameter. The appendiceal and intestinal serosa are pink tan and smooth. The colonic serosa has a focus of retraction and is inked black.  Focally hemorrhagic lobulated yellow tan adipose tissue spans the length of the specimen measuring up to 6 cm in thickness. There is also omentum (17.2 to 15 x 1 cm) specimen is opened to reveal a circumferential tan-pink mass measuring 3.5 cm in length and 8 cm in width. The mass is located in the transverse colon, immediately adjacent to a tattoo site, 32.2 cm from the proximal margin, 10.3 cm from the distal margin, and 16.5 cm from the ileocecal valve. Sectioning shows that the tumor invades the muscularis. The depth of invasion is 0.3 cm grossly; the tumor has a thickness of 0.6 centimeters. There are two tan-pink polypoidal masses (1.1 cm and 0.4 cm in greatest dimension) located 3.0 cm and 4.5 cm from ileocecal valve, respectively. The remaining mucosa is unremarkable. The attached adipose tissue is thoroughly examined and all identified lymph nodes are submitted. Representative sections of the specimen are submitted for permanent sections and for Summary of sections: P - proximal margin shave - distal margin shave T  tumor ** Continued on next page **
+
+--- Page 3 ---
+Page 3 of 3 P-polypoid masses RS  -representative sections A appendix, representative sections. IN - lymph nodes BLN - bisected lymph nodes Summary of Sections:. Part 1: Terminal ileum, appendix, and ascending colon; Resection Block Sect. Site PCs H 5 1 BLN 10 1 DM 81 LN P 1 H15 PM 11 RS T 5 ** End of Report.
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diff --git a/output/text/b8487221-f11f-40b9-88f1-01bbfde8f0b1.txt b/output/text/b8487221-f11f-40b9-88f1-01bbfde8f0b1.txt
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index 0000000000000000000000000000000000000000..641c539d0291d4e3210ff4abbabef69919285c71
--- /dev/null
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+
+--- Page 1 ---
+athology  Report Accession Number: Report Status:. Final Type: Pathology Report COLON, SEGMENTAL RESECT FOR TUMOR Accessioned On: BRODSKY, DIAGNOSI SPECIMEN LABELED "RIGHT COLON": INVASIVE MUCINOUS ADENOCARCINOMA OF THE COLON, moderately differentiated, (2.6 cm), arising in association with an adenoma. Tumor focally invades into but not through muscularis propria.. No lymphovascular invasion is identified.. Eight (8) lymph nodes are negative for tumor.. AJCC Stage: T2 NO Mx. CLINICAL DATA: History: None given. Operation: R colectomy TISSUE SUBMITTED: 1. R GROSS DESCRIPTION: by The specimen is . received fresh in one part, labeled with the patient's name,. unit number and "#1 right colon".. The specimen consists of a seggment of ileocecum. The ileum measures 10 cm in length and 2.3 cm in diameter with a surgical resection margin (2.2 cm in diameter).  The colon measures 20 cm in length and 6 cm in diameter with a surgical resection margin (3.5 cm in diameter). A red/tan mass (2.6 x 1.7 x 0.8 cm) is identified in the cecum.. The mass is 12 cm from the ileal resection margin (inked black) and 17 cm from ileocecal valve and does not invade through the serosa..  The serosal surface is grossly unremarkable.  The serosal surface adjacent to the tumor is inked. black. No appendix is identified. However, a white/tan possible scar. (2 x. 0.5 cm is present on the serosal surface of the cecum. Micro 1: ileal surgical resection margin en face, 2 frags, Micro 2 : colon resection margin en face, 1 frag, Micro 4 frags Micro 6: normal appearing ileal tissue, 1 frag,. Micro 7: normal appearing colonic tissue, 1 frag Micro 8-11: possible lymph nodes, 15 frags,| Micro 12: possible scar tissue, 1 frag, mjy Reports to: SPECIMEN TYPE: COLON, SEGMENTAL RESECT FOR TUMOR Page: 1 of 1
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diff --git a/output/text/b851a6d1-bef1-40ef-8e58-5b859d7649fd.txt b/output/text/b851a6d1-bef1-40ef-8e58-5b859d7649fd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f92fafa8b561aad65cd35cd0839e1db15ce64f88
--- /dev/null
+++ b/output/text/b851a6d1-bef1-40ef-8e58-5b859d7649fd.txt
@@ -0,0 +1,24 @@
+
+--- Page 1 ---
+PAGE 1 PATIENT AGE/SEX: /F REG DR! Received: Collected: Copiea to: UUID:70AAF737-589D-454E-B779-1BB44691E0D3 TCGA-IQ-A61L-01A-PR Redacted SPECIMEN ID: A. LYMPH NODE - RIGHT NECK DISSECTION LEVEL LA, 1B,2A, 3,4, LYMPH NODE - RIGHT NECK DISSECTION LEVEL 2B. B. C. TONGUE - COMPOSITE RESECTION PARTIAL GLOSSECTOMY AND TONSILECTOMY, D. TONGUE - ADDITIONAL DEEP POSTERIOR TONGUE RIGHT SIDE, E. TONGUE - ADDITIONAL RIGHT POSTERIOR DEEP TONGUE FS. F. FLOOR OF MOUTH, NOS - RIGHT ANTERIOR FLOOR OF MOUTH MARGIN CLIP SUPERIOR FS, G. TONGUE - RIGHT ANTERIOR DORSAL TONGUE MARGIN CLIP SUPERIOR FS, H. TONGUE - MIDDLE DORSAL TONGUE MARGIN FS, I. TONGUE - ANTERIOR DEEP TONGUE MARGIN FS, J. TONGUE - RIGHT POSTERIOR DORSAL TONGUE MARGIN FS, K. FLOOR OF MOUTH, NOS - POSTERIOR FLOOR OF MOUTH MUCOSA MARGIN FS, L. TONGUE - POSTERIOR DEEP TONGUE MARGIN FS, M. MOUTH - ADDITIONAL POSTERIOR FLOOR OF MOUTH FINAL DIAGNOSIS. A. RIGHT NECK DISSECTION LEVEL 1A, 1B, 2A, 3, 4; Thirty lymph nodes, negative for carcinoma (0/30). B. RIGHT NECK DISSECTION LEVEL 2B: Twelve lymph nodes, negative for carcinoma (0/12). C. COMPOSITE RESECTION PARTIAL GLOSSECTOMY AND TONSILLECTOMY: INVAsIVE sQuAMOUs CELL cARcINOMA, keratinizing, 3.8 cm, right lateral tongue. If you receive this report inadvertently, please call return the report to us by mail. and IcD-o -3 807i93 Sute Jengue NoS Co2.9  5/4113
+
+--- Page 2 ---
+PAGE 2 (Continued) FINAL DIAGNOSIS ** * (Continued) The tumor is 1.5 cm in depth. Tumor has focal necrosis with abscess formation.. Inked margins are focally positive for tumor (posterior margin "c4"). Medial margins are negative for tumor.. Negative for lymphovascular invasion. Negative for perineural invasion. AJCC: pT2. pNO, pMx See Cancer Case Summary. Note: For final posterior resection margin, see other specimens received. D.  ADDITIONAL DEEP POSTERIOR TONGUE RIGHT SIDE:S INVAsIVE sQuAMOUs cELL CARcINOMA, keratinizing, Q.1 cm, within fibroadipose tissue. Inked margins negative for carcinoma. Lymphoid tissue and squamous mucosa, negative for carcinoma. ADDITIONAL RIGHT POSTERIOR DEEP TONGUE:S E. Skeletal muscle and minor salivary gland, negative for carcinoma. F. RIGHT ANTERIOR FLOOR OF MOUTH: Squamous mucosa, negative for carcinoma.. This report is privileged, confidential and exempt from disclosure under applicable law. If you receive this report inadvertently. please call and return the report to us by mail.
+
+--- Page 3 ---
+PAGE 3 (Continued) ** FINAL DIAGNOSIS *** (Continued) G. RIGHT ANTERIOR DORSAL TONGUE: Squamous mucosa and skeletal muscle, negative for carcinoma. H.  MIDDLE DORSAL TONGUE MARGIN: Skeletal muscle, negative for carcinoma. I. ANTERIOR DEEP TONGUE MARGIN: Skeletal muscle and nerve, negative for carcinoma. J. RIGHT POSTERIOR DORSAL TONGUE MARGIN: Skeletal muscle and fragment of squamous mucosa, negative for carcinoma. K.  POSTERIOR FLOOR OF MOUTH MUCOSA MARGIN: Cauterized fragment of fibroconnective tissue and fragment of squamous mucosa, negative for carcinoma.. Marked chronic inflammation.. L. POSTERIOR DEEP TONGUE MARGIN:S Skeletal muscle, negative for carcinoma. M. ADDITIONAL POSTERIOR FLOOR OF MOUTH: Squamous mucosa with marked keratosis and chronic inflammation. Skeletal muscle and minor salivary gland, negative for carcinoma. This report is privileged, confidential and exempt from disclosure under applicable law. If you receive this report inadvertently. please call return the report to us by mail.. and
+
+--- Page 4 ---
+PAGE 4 (Continued) FINAL DIAGNOSIS (Continued) Surgical Pathology Cancer Case Summary. Lateral border of tongue, right. Specimen: Received: In formalin Procedure:  Resection Glossectomy: (right hemiglossectomy) Specimen Integrity: Intact Specimen Size: Greatest dimension: 6 x 3.2 x 2.4 cm Specimen Laterality: Right Tumor Site:  Lateral border of tongue Tumor Focality: Single focus. Tumor Size: Greatest dimension: 3.8 cm Additional dimensions: 3.2 x 1.5 cm Tumor Thickness: 15 mm Tumor Description: Endophytic Ulcerated Histologic Type: Squamous cell carcinoma, conventional, keratinizing Histologic Grade: Gl: Well differentiated Margins: Margins uninvolved by invasive carcinoma (resection specimen only) Distance from closest margin: 7 mm Specify margin: Medial Margins involved by invasive carcinoma Specify margin: Posterior (resection specimen only) Treatment Effect: Indeterminate Lymph-Vascular Invasion: Not identified Perineural Invasion: Not identified Pathologic Staging (pTNM): Primary Tumor (pT): pT2: Tumor more than 2 cm but not more than 4 cm in greatest dimension Regional Lymph Nodes (pN): pNO: No regional lymph node metastasis Number of Lymph Nodes Examined: 42 Number of Lymph Nodes Involved:. 0 This report is privileged, confidential and exempt from disclosure under applicable law. and return the report to us by mail..
+
+--- Page 5 ---
+PAGE 5 (ContInued) * # * FINAL DIAGNOSIS (Continued) Distant Metastasis (pM): Not applicable Additional Pathologic Findings: Inflammation: Peritumoral lymphocytic infiltrate. CLINICAL HISTORY- PRE-OP DX: Not provided Procedure: Right hemiglossectomy, right neck dissection, tracheotomy and direct. laryngoscopy. RELEVANT CLINICAL HX: Not provided GROSS DESCRIPTION: A. Received in formalin and labeled "Right neck dissection, levels IA, IB, IIA, IIl and Iv" is an unoriented, tan-brown, fibrofatty tissue fragment, 5.0 x 3.5 x 2.4 cm.. There lobulated gland. No suspicious lesions are grossly identified. Representative sections are submitted as follows: Cassette #1: Representative sections of the salivary gland. Cassette #2: Five possible lymph nodes Cassette #3: Five possible lymph nodes Cassette #4: Five possible lymph nodes Cassette #5: Three possible lymph nodes Cassette #6: Five possible lymph nodes Cassette #7: Three possible lymph nodes Cassette #8: Four possible lymph nodes B Received in formalin and labeled "Right neck dissection, level Iis" is a tan-brown. fibrofatty tissue fragment, 4.4 x 1.5 x 1.4 cm. The specimen is unoriented. The largest lymph node measures 2.0 x 1.5 x 0.5 cm. The specimen is submitted as follows:. Cassette #1: Largest lymph node bisected in toto. Cassette #2: Eight possible lymph nodes Cassette #3: Three possible lymph nodes C. Received in formalin and labeled *Composite resection of partial glossectomy, This report is privileged, confidential and exempt from disclosure under applicable law.. return the report to us by mail. and
+
+--- Page 6 ---
+PAGE 6 (Continued) (Continued) GROSS DESCRIPTION: tonsillectomy, stitch and tongue base" is a right hemiglossectomy specimen, 6.0 x 3.2 x 2.4 cm. The specimen is oriented with one stitch at tongue base. Attached to it. there is a tonsil, 2.2 x 1.8 x l.0 cm. There is a 3.8 x 3.2 cm, white, firm nodular lesion at the lateral aspect of the specimen. A 0.s x 1.0 x 0.5 cm block of tissue seems to have been taken away, likely for Tumor Bank. The firm, tan-white lesion has irregular borders. The specimen has been inked as follows: anterior margin inked yellow, medial margin inked red, posterior margin inked black, tumoral surface. on the lateral side inked orange, inferior margin inked green. The tumor is 0.8 cm from the inked anterior area of the specimen, i.0 cm from the closest medial margin. 1.0 cm from the closest inferior margin and extends 1.s cm in depth. Representative sections are submitted as follows: Cassette #1: Perpendicular section in relation to anterior margin and. tumor Cassettes #2&3: Full composite section of tumor showing relationship of. the tumor with the medial margin and inferior margin. Cassette #4: Perpendicular section of tumor in relation to inferior margin. and deep margin Cassette #5: Representative section of tumor showing connection to adjacent tonsil Cassette #6: Tumor in relation to tonsil Cassette #7: Representative section of tumor Cassette #8: Representative section of tonsil (three fragments) Cassette #9: Additional sections of tumor D. Received in formalin and labeled "Additional deep posterior tongue, right side" is a 2.1 x l.l x o.a cm, tan-brown, firm tissue fragment. The specimen is unoriented. The specimen has been inked black and submitted in toto in three cassettes.. Received fresh and labeled "Additional right posterior deep tongue" is a 2.0 x 0.5 x E. 0.3 cm, tan-brown soft tissue fragment. Submitted in toto in one cassette for frozen section. F. Received fresh and labeled sRight anterior floor of mouth margin" is a 1.0 x 0.4 x 0.1 cm, tan-white soft tissue fragment. Submitted in toto in one cassette for frozen section. G. Received fresh and labeled "Right anterior dorsal tongue margin" is a 2.0 x 1.8 x 0.1 cm, tan-white soft tissue fragment. Submitted in toto in one cassette for frozen. section. This report is privileged, confidential and exempt from disclosure under applicable law. and If you receive this report inadvertently, please call. return the report to us by mail.
+
+--- Page 7 ---
+PAGE 7 (Continued) GROSS DESCRIPTION: (Continued) Received fresh and labeled "Middle dorsal tongue margin" is a 1.2 x 0.9 x 0.2 cm, H. tan-white soft tissue fragment. Submitted in toto in one cassette for frozen section. I. Received fresh and labeled "Anterior deep tongue margin" is a 1.0 x 0.4 x 0.2 cm,. tan-brown soft tissue fragment. Submitted in toto in one cassette for frozen section. J. Received fresh and labeled "Right posterior dorsal tongue margin" is a 1.7 x 1.0 x 0.3 cm, tan-brown soft tissue fragment. Submitted in toto in one cassette for frozen section. K. Received fresh and labeled "Posterior floor of mouth mucosa margin" are multiple. tan-white soft tissue fragments, 1.4 x 1.6 x 0.1 cm . Submitted in toto in one. cassette for frozen section. L. Received fresh and labeled "posterior deep tongue margin" is a 0.7 x 0.4 x 0.1 cm,. tan-brown soft tissue fragment. Submitted in toto in one cassette for frozen section. M. Received in formalin and labeled "Additional posterior floor of mouth" is a 2.0 x 0.3 x O.l cm, tan-pink soft tissue fragment. Submitted in toto in one cassette.. OPERATING ROOM CONSULT(FS-CYT) EFs. Additional right posterior deep tongue: Negative for tumor. FFs. Right anterior floor of mouth: Negative for tumor. GFs. Right anterior dorsal tongue: Negative for tumor.. HFs. Middle distal tongue margin: Negative for tumor.. IFs. Anterior deep tongue margin: Negative for tumor.. JFs. Right posterior dorsal tongue margin: Negative for tumor.. KFs. Posterior floor of mouth mucosa margin: Keratosis and mild dysplasia. Negative for carcinoma.. and return the report to us by mail.
+
+--- Page 8 ---
+PAGE 8 (Continued) OPERATING ROOM CONSULT (FS-CYT) : (Continued) Negative for tumor. LFs. Posterior deep tongue margin:. This report is privileged, confidential and exempt from disclosure under applicable law. If you receive this report inadvertently, please call. ind return the report to us by mail.. lw 4/9/13
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diff --git a/output/text/b855943d-db71-4381-9392-9d68faeb6986.txt b/output/text/b855943d-db71-4381-9392-9d68faeb6986.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c83b0243c3b13c12f2b6e21f57f7f0fcd50e77f5
--- /dev/null
+++ b/output/text/b855943d-db71-4381-9392-9d68faeb6986.txt
@@ -0,0 +1,24 @@
+
+--- Page 1 ---
+1cs-0-3 4905 Cascm`oma, ifltrnhng duct N0s 8500/3 Collection Date: S... Hospital of Origii Copy to C50.9.: 4 QC Pathologist: FINAL PATHOLOGIC DIAGNOSIS: A. Left axillary sentinel lymph node: One lymph node containing metastatic carcinoma. Confirms frozen section diagnosis. Size of involvement within the node: 0.3 cm. B. I.eft breast mastectomy: Residual invasive ductal carcinoma. Size: 2.5 cm. Architectural score: 2/3. Nuclear score: 2/3. Mitotic score: 1/3. Total score: 5/9, Grade I. Carcinoma is adjacent to previous biopsy cavity. No evidence of skin or nipple involvement. Deep margin of excision is free of carcinoma. Prognostic panel was performed on the original biopsy and will not be repeated unless requested. Multifocal areas of ductal carcinoma in situ present in uninvolved quadrants of breast. DCIS is high-grade comedo carcinoma type. Largest area of confluent DCIS is approximately 1.0 cm. TNM Classitication: T2 pN1 MX. COMMENTS: CLINICAL HISTORY: Preoperative Diagnosis: Left modified radical mastectomy with sentinel node mapping with frozen section. Invasive ductal carcinoma, ER positive, PR positive, Ki-67 (MIB1) 33%. Postoperative Diagnosis: Symptoms/Radiologic Findings: SPECIMENS: A. Left axilla sentinel node with frozen section B. Left breast CODES: UUID:926E9386-EF7C-4F13-824D-13D08B7F7938 TcgA-Ac-A23C-01A-pr P.1
+
+--- Page 2 ---
+PROCEDURAL DEMOGRAPHICS: Date of Procedure: Accession Date/Time: GROSS DESCRIPTION: The snecimen is received in two containers labeled - A. Auumonally labeled right sentinel node and contains a 1.7 cm yellow tan fibrofatty soft tissue. The specimen is bisected and entirely submitted for frozen section with the. residual entirely resubmitted fnr nermanent section in cassette A labeled B. Additionally labeled left breast and contains a 641 gram, 20.0 x 13.5 x 7.0 cm simple mastectomy specimen partially surfaced by a 17.5 x 9.3 cm ellipse: of pink tan wrinkled skin bearing a central 1.4 x 1.2 x.0.5 cm everted nipple. No orientation is offered or possible. The deep margin is inked and the specimen is serially sectioned to reveal a 2.5 x 1.5 x 1.5 cm ill defined gray white gritty mass that resides 3.5 cm from the skin surface and approaches to within 3.5 cm of the inked deep margin. Located immediately adjacent to this mass is a 3.5 x 2.8 x 2.3 cm shaggy, necrotic cavity consistent with previous biopsy site. This cavity resides 1.5 cm below the skin surface and approaches to within 3.5 cm of the inked deep margin. The remainder of the cut surface is comprised of predominantly yellow tan adipose tissue admixed with moderate amounts of interspersed gray white fibrous tissue. No additional masses are identified. Also received in the same container is an 11.5 x 2.0 x 1.5 cm strip of pink tan wrinkled skin with adherent yeilow tan fibrofatty soft tissue. Sectioning reveals a yellow tan fibrofatty cut surface with no discrete lesions. Representative sections are submitted in cassettes B1-B13 :  designated as follows: B1-- nipple; labeled B2-- inked deep margin, perpendicular; B3-B5-- mass; B6-B9-- previous biopsy cavity; B10-B12-- representative sections from the three uninvolved quadrants; B13-- sections from separately submitted skin and fibroadipose tissue. Additionally, a yellow and green cassette are submitted for genomic research each labeled INTRA-PROCEDURE CONSULTATION: A. Frozen section diagnosis: Metastatic neoplasm approximately 0.3 mm on. frozen section per Dr. P2
+
+--- Page 3 ---
+margin. The specimen is inkl. .s follows: Superficial-. blue, deep - black, superior - green, and inferior - orange. The specimen is serially sectioned in a medial to lateral fashion to reveal a 0.9 x 0.8 x 0.6 cm white-tan, firm. well-defined mass/possible lymph node which extends to the medial, superior, inferior, superficial margins, is within 0.7 cm of the deep margin and greater then 1 cm from the lateral margin. The mass is covered in a moderate amount of overiying blue surgical dye. Remaining breast parenchyma is approximately 10% tan, somewhat dense fibrous tissue. Cut surfaces are also remarkable for a few foci of hemorrhage up submitted in cassettes labeled as folfows: A1-A7 are in a medial to lateral fashion. A1 is a full cross section of the mass to show the nearest superficial, deep, superior, inferior margins; A2. Additional section of the mass; A3-A7. Remaining full cross sections of the specimen; A8. Medial margin and transverse sections; A9. Lateral margin and transverse sections. B. Additionally labeled "2 - Left medial margin, old margin up, new margin down" and consists of a 1.9 x 1.4 x 0.8 cm portion of yellow-tan, lobulated, fibrofatty breast tissue, stitched to a Telfa pad to indicate that the new margin is face down; new margin is inked blue. Sectioning reveals tan-yellow, lobulated, fibrofatty and friable cut surfaces. No significant fibrous tissue or distinct nodular lesions are identified. The entire specimen is submitted  seauentially in cassettes B1 and B2 labeled. INTRA-PROCEDURE CONSULTATION: MICROSCOPIC DESCRIPTION: THERAPEUTIC MARKERS Test Description Breast Cancer Analvsis using Immuno-histochemistry, I. and Pathologist review. . is a FDA approved adjunctive, cornputer-assisted and interactive microscopy system which aids the pathotogist in the detection, classification, and counting of cells of interest thereby standardizing slide scoring through quantitative assessment of marker intensity, size and shape. Estrogen / Progesterone Receptors ER/PR ER = Rabbit Monoclonal Antibody (clone SP1) PR = Rabbit Monoclonal Antibody (Clone 1E2) Anti-Estrogen receptor (ER) primary antibody is a rabbit monoclonal antibody (IgG) that is used for the qualitative detection of estrogen receptor antigens in sections of formalin-lixed, paraffin-embedded tissue on an automated slide stainer platform used in conjunction with an indirect biotin streptavidin detection system. The ER antibody is directed against the epitrope.present on human ER nratein P 3
+
+--- Page 4 ---
+Iocated in the nucleus of norr  ind neoplastic cells. This test is indicated as and aid in tne managernent, prognosis,. and prediction of therapy outcome of hreast cancer. Anti-Progesterone Receptor (PR) primary antibody is a rabbit monoclonal antibody (IgG) that is used for the quantitative detection of the A, B and C isoforms of human progesterone receptor antigens in sections of formalin-fixed, paraffin-embedded tissue on an automated stide stainer platform used in conjunction with an indirect biotin streptavidin detection system. This test is indicated as and aid in the management, prognosis, and prediction of therapy outcome of breast cancer. The significance of PR is  its role in determining the functionality of estrogen receptors in breast cancer cells. The presence of estrogen does not guarantee a response to endocrine therapy. One way to evaluate the functionality of the ER present in breast carcinoma is to determine if the proteins regulated by ER are expressed. PR receptor is such a protein, and has historically been-used to monitor the functionality of ER. The measures the percentage of positively stained nuclei of the tumor cells. Note: False negatives are possible. Positive staining for receptor in the norma! glands if present is a good internal control, and increases the likelihood that a negative result is a true negative. Ki-67 = Rabbit Monoclonal (clone 30-9) Anti-Ki-67 primary antibody is directed against the C-terminal portion of the Ki-67 antigen, which is expressed in the nuclei of proliferating cells (normal and neoplastic). The antibody identifies proliferating activity in sections of formalin-fixed, paraffin-embedded tissue on an automated slide stainer platform used in conjunction with an indirect biotin streptavidin detection system.. Assessment of tumor proliferative activity, IHC staining of tumor cell nuclei, can be used for prognosis and therapy planning. Ideal for use with small breast cancer specimens. The percentage of positively stained tumor nuclei is renorted The . is an indirect biotin method. Interpretation utilizes the instrument. The. is a Tissue Fixation. ER/PR testing guidelines were released which include fixation recommendations. All tissue should be fixed in neutral buffered formalin as soon as possible. Excisional and mastectomy specimen tissue should be fixed for a minimum of 6 and maximum of 72 hours. For tissue not fixed within the optimal time period or if fixation time is unknown it should be noted on report. Any negative Her2 IHC result without optima! fixation time should have Her2 FiSH testing performed. p4
+
+--- Page 5 ---
+tISH, HER2/neu refl to IHC: CYTOGENETIC RESULTSCytogenetic Reference #: Test Setup Date: est Completion Date: Specimen Source: Left breast Clinical History:Invasive ductal carcinoma; HER2 IHC: Not Availablelnterphase Cells: 30 Metaphase Cells: OFISH RESULTS:POSITIVE HER2 oncogene amplification detected by FISH analysisRatio of HER2 to D17Z1 is 8.0 (average count: HER2: 14.9, D17Z1: 1.9)nuc ish(D17Z1x1 3,HER2x5 25)[30]INTERPRETATION and COMMENTS:The HER2 FISH assay (Abbott Molecular) revealed amplification of the HER2 oncogene.A ratio of >2.2 is considered to indicate amplification. Slides from this sample were evaluated by an in-house. pathologist and deemed adequate for HER2 FISH analysis. The formalin fixation'time was between 6 hours and 48 hours per the submitting facility. Controls were performed and provided the anticipated resuits. The imaging method was manual. This case has been reviewed by at least 2 observers. Resuits from this test are intended for use as an adjunct to prognosis in stage ti, node positive breast cancer patients. Clinically relevant amplification has been documented only when an invasive component is involved. Clinical correlation is recommended. Ihis test is also indicated as an aid in the assessment of patients for whom Herceptin treatment is being considered. The performance characteristics of this assay have been determined by Performance characteristics refer to the anatytical performance of the test. Reference:Wolff et al. Arch Patho! Lab Med
+
+--- Page 6 ---
+Collection Date: Hospital of Origin: Copy to QC Pathologist: *** ADDENDUM REPORT ADDENDUM REPORT NUMBER TWO FISH RESULTS: Specimen Source: Left breast () A1)POSITiVE HER2 oncogene amplification detected by FISH anaiysisRatio of HER2 to D17Z1 is 8.0 (average count: HER2: 14.9, D17Z1: 1.9)nuc ish(D17Z1x1 3,HER2x5 25)[30][Specific testing information from this report has been added to the microscopic description] Addendum Report Issued By: : ADDENDUM REPORT NUMBER ONE BREAST PROGNOSTIC PANEL: (test results on block A1). TEST RESULT REFERENCE RANGES Estrogen Receptor: POsITiVE (91%) = 1% is Positive  1% is Negative Staining Intensity: Strong. Progesterone Receptor: POsiTiVE (53%) = 1% is Positive < 1% is Negative Staining Intensity: Strong Ki-67 (MIB1) Proliferation Marker: H!GH (33%) > 20% is High 10-20% is Borderline < 10% is Low These results were interpreted by I Indiana. An additional addendum report will tollow when. Her-2-neu tests are comp!eted. [Specific testing information and references have been added. to the microscopic description) The original diagnosis remains unchanged.. Addendum Report Issued by:
+
+--- Page 7 ---
+EXAMINATION: MRI BRFASTE .ATERAL 1 Completed: FULL RESULT: Indication: Newiy dlagnosed left breast cancer.. Comparison: Multiple mammograms dating back to. FINDINGS: Bilateral breast MRI was performed with and without contrast. CAD-stream. computer-aided detection system was utilized to obtain multiplanar and 3-D reconstruction images. Subtraction images were created from dynamic contrast data. All Images were evaluated at a work station.: The right breast'demonstrates no abnormal areas of enhancement or adenopathy. On the left, axillary lymph nodes are more hypervascular than on the right but morphologically they are similar and symmetric. In the anterior upper-outer quadrant of the left breast, there Is a. 1.5 x 1.1 x 1.3 cm irregular enhancing mass consistent with the patient's known malignancy. Muitiple scattered nodules are identified throughout the left breast.  #1--3 cm superior, posterior and medial to the known malignancy is a 6 x 5 x 7 mm enhancing nodule. Review of the. prior mammograms demonstrates that this was not present prior to this year's mammogram and therefore is highly suspicious for a satellite lesion. #2--Approximately 1 cm posterior to the known malignancy'is a 3 mm nodular area ol enhancement.. #3--2.3 cm inferior and laterai to the known malignancy is a 5 mm nodule . These are all suspicious for satellite lesions. #4--In the far lateral aspect of the breast, there is a 1-2 mm enhancing nodule.. #5--Even more laterally, is a 3-4 mm enhancing nodule. This contains a fatty hilum and these latter two nodules are likely lymph nodes given their far lateral location and appearance. #6--In the posterior medial left breast a 3 mm enhancing nodule is seen.. #7-- in the far medial skin of the left breast there is a 4 x 2 x 4 mm enhancing nodule. This could represent either a benign or malignant skin tesion and therefore clinical correlation is recommended.  Interspersed between the known malignancy and the suspected satellite lesions, are vague areas of subthreshold nodular enhancement. A 1.6 and 1.4 cm area of this type of enhancement is seen in the.medial.breast..Comparison of the.MIP.
+
+--- Page 8 ---
+projections show that these ol dI areas of scattered enhancement and nodutarity are very asymmetric to the right and therefore may relate to additionai disease . Inclusion of all of the areas of enhancement shows that a large percentage of the breasts may be involved with disease measuring up to 8.0 x 6.8 cm.. Muiticentric disease should be excluded. If breast conservation therapy. is considered, then biopsy of one or more of the  nodules will be needed. The 7 mm lesion, 3 cm from the known malignancies. (#1) would likely be visible by ultrasound and amenable to biopsy. Some of the smaller more posterior nodules in the. medial breast may not be visible by ultrasound. IMPRESSION: 1. The patlent's known malignancy is identified in the anteror upper-outer quadrant and measures 1.5 cm. There are  multiple scattered 'enhancing nodules seen within the breast that are.  suspicious for satellite lesions. Biopsies as clinically indicated should be performed. HIstory Allergies: NKDA Current Meds:Se aHoehec tise please 1R- IT- VITAL SIGNS: BP- P. PHYSICAL  See preprocedure record N/A 4 WNL Abnorma! Mental Status 0 HEENT  D 8 Heart 0 Lunga 0 0 Abdomen 0 0 Pelvic Extremtiesd 0 PMH: sibromwodaia.. SurgicalHxKnee rolaeencstet breashiopsy- Family Hx: ben?+C ne Lab/X-Ray: Norma) Abnormal (explain) =tbhologyInyasive drlal CQrein on(Q) Admit / Pre-Op Dlagnosis: [eLL hIeat CQkeer Treatment Plan: .. le++ nodihedJodmna Smastee lonyy whh senhinel hodle hopping Wilc porer section M.D. Time .  H&P Date_ ignatura  Surgery Date
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diff --git a/output/text/b8573344-94dd-4fc9-b89d-08b603f09093.txt b/output/text/b8573344-94dd-4fc9-b89d-08b603f09093.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e756f9ce8949733e1c963b5c6617bde26e4c3a6d
--- /dev/null
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+
+--- Page 1 ---
+DISQUALFETZ UUID:4F047F5B-EF3A-4590-8E7A-D90A52860324 TCGA-A1-A0SM-01A-PR Redacted Ics-0 - 3 Carcnono-,vifiHtrativg cluct,Nos 85ov13 Jn 1ofa1fu Sit: bresst Nos C50.9 Final Pathologic Diagnosis: A. Left axillary sentinel lymph node #1, biopsy: No tumor in one lymph node (0/1). B. Left axillary sentinel lymph node #2, biopsy: No tumor in one lymph node (0/1). C. Left axillary minor sentinel lymph node #3, biopsy: No tumor in one lymph node. (0/1). D. Left breast, mastectomy: 1. Invasive ductal carcinoma, 3.5 cm, grade 2, associated with microcalcifications;. see comment. 2. Ductal carcinoma in situ, cribriform, intermediate grade. 3. Gynecomastia.. Note: Breast Tumor Synoptic Comment - Laterality: Left. - Invasive tumor type: Invasive ductal carcinoma. - Invasive tumor size: 3.5 cm maximum diameter. - Invasive tumor grade (modified Bloom-Richardson): Grade 2. Nuclear grade: 3 = 3 points.. Mitotic count: <10 mitotic figures/10 HPF = 1 point. Tubule/papilla formation: Definite tubule formation in <10% = 3 points.. Total points and overall grade: 7 points = grade 2. - Lymphatic-vascular invasion: None. - Perineural invasion: None.. - Resection margins for invasive tumor: - Deep margin: Negative; (tumor is 0.3 cm away, on slide D4). Page I of 8
+
+--- Page 2 ---
+Surgical Pathology - Working Draft - Medial margin: Negative; (tumor is >1 cm away).. - Lateral margin: Negative; (tumor is >1 cm away). - Anterior/superior margin: Negative; (tumor is >1 cm away). - Anterior/inferior margin: Negative; (tumor is 0.8 cm away, on slide D3).. - Ductal carcinoma in situ (Dcis) type: Cribriform. - Ductal carcinoma in situ size: 0.3 cm. - Ductal carcinoma in situ nuclear grade: Intermediate nuclear grade. - Necrosis in Dcis: None. - Microcalcifications: Present in invasive carcinoma. - Resection margins for ductal carcinoma in situ: - Deep margin: Negative; (tumor is >1 cm away). - Medial margin: Negative; (tumor is >1 cm away). - Lateral margin: Negative; (tumor is >1 cm away). - Anterior/superior margin: Negative; (tumor is >1 cm away). - Anterior/inferior margin: Negative; (tumor is >1 cm away).. - Lymph node status: Negative (0/3). - AJCc/UICC stage: pT2NOMX. - Nontumorous breast tissue: Gynecomastia. - Nipple: No tumor. - Skin/dermis: No tumor. - Additional comments: Each sentinel lymph node was examined with level sections. No metastatic carcinoma was identified.  has reviewed selected slides and concurs with the findings. Intraoperative Consult Diagnosis. FS1 (A) Sentinel lymph node #1. left axilla, biopsy: No carcinoma. Cytologic preparations and frozen section. FS2 (B) Sentinel lymph node #2, left axilla, biopsy: No carcinoma. Cytologic preparations and frozen section.  Clinical History The patient is a -year-old with invasive ductal carcinoma of the left breast. This diagnosis was established by core biopsy at another institutinn --- That hinncy showed that the carcinoma is ER, PR, and HER-2-positive. Gross Description The specimen is received fresh in four parts, each labeled with the patient's name and unit number. Part A, labeled "; consists of a single soft irregular. red-yellow candidate lymph node measuring 2.7 x 1.8 x 1.3 cm. Extraneous fatty tissue is removed. The candidate lymph node is bisected. Touch and scrape preparations are made. The remaining lymph node is submitted for frozen section, and subsequently submitted in cassette A1. The unused fatty tissue is entirely submitted in cassette A2. Part B, labeled " nsists of a single soft irregular red-yellow candidate lymph noae measuring 1./ x 0.8 x 0./ cm. Extraneous fatty tissue is removed. The lymph node is bisected. Touch and scrape preparations are made. The remaining lymph node is submitted for frozen section diagnosis 2, and subsequently submitted in cassette B1. The unused fatty tissue is entirely submitted in cassette B2.. Part C, additionally labeled " " consists of a single fragment of yellow fibrofatty tissue measuring 2 x 1.5 x 0.5 cm. One candidate lymph node is palpated within the fatty tissue. The Paee 2 nf 8
+
+--- Page 3 ---
+Surgical Pathology - Working Draft specimen is entirely submitted in cassette C1.. Part D, additionally labeled consists of a mastectomy specimen oriented with. a short suture superior and a .uuy suture iateral. The specimen measures 14.2 cm from superior to inferior, 14.5 cm from medial to lateral and 3 cm from anterior to posterior. On the anterior surface, there is a skin ellipse measuring 12.4 x 4.6 cm. Within the skin ellipse is a nipple/areola measuring 2 cm in diameter. A firm mass is palpated deep and medial to the nipple in the inner upper and lower quadrants. The specimen is inked for microscopic evaluation, with the anterior superior inked in blue, the anterior inferior inked in green and the posterior inked in black. The specimen is then sectioned into fifteen slices, numbered from medial to lateral. The nipple-areolar complex appears in slices 5-7.. Sectioning shows an irregular, lobulated, pink-tan mass measuring 3.5 cm; this is located in the inner Iower quadrant deep to the nipple, in slices 5-7. The cyst mass extends to within 0.7 cm of the deep. margin, 1.7 cm from the anterior superior margin, and 1.9 cm from the anterior inferior margin. The remainder of the breast parenchyma consists of yellow fatty tissue and is unremarkable. Cassettes are submitted as follows: Cassettes D1-D2: Nipple. Cassettes D3-D4: Mass, slice 5. Cassettes D5-D7: Mass, slice 6 (widest cross-section superior to inferior).. Cassette D8: Representative medial margin. Cassette D9: Representative latera! margin. Cassette D10: Representative unremarkable inner upper quadrant, slice 2. Cassette D11: Representative unremarkable inner upper quadrant, slice 4. Cassette D12: Representative unremarkable inner lower quadrant, slice 3. Cassette D13: Representative unremarkabte inner lower quadrant, slice 4. Cassette D14: Representative unremarkable outer upper quadrant, slice 9. Cassette D15: Representative unremarkable outer upper quadrant, slice 12. Cassette D16: Representative unremarkable outer lower quadrant, slice 10. Cassette D17: Representative unremarkable outer lower quadrant, slice 13. VPathology Resident. /Pathologist Signed: Fee Codes: Addenda Addendum. Date Ordered: Status: Signed Out Date Complete: By: Date Reported: Addendum Comment An immunohistochemical test for estrogen and progesterone receptors as well as for HER2 was performed on block D6. The test for estrogen receptors is positive. There is variable nuclear stalning (ranging from weak to strong) in ~20% of tumor cells. The test for progesterone receptors is negative. There is no nuclear staining in any of tumor cells. Internal positive control is present.. Result of HER2/neu test: This carcinoma is positive for HER2/neu oncoprotein over-expression. Page 3 of 8
+
+--- Page 4 ---
+Surgical Pathology -  Working Draft An immunohistochemical assay was performed using the CB11 monoclonal antibody to HER2/neu. oncoprotein. The staining intensity of this carcinoma was 3 on a scale of 0-3.. Carcinomas with staining intensity scores of O or 1 are considered negative for over-expression of HER2/neu oncoprotein.. Those with a staining intensity score of 2 are considered indeterminate. We and others have observed that many carcinomas with staining intensity scores of 2 do not show gene amplification. All carcinomas with staining intensity scores of 2 are therefore. submitted for FIsh testing. The results of the FisH test are issued dlrectly from the molecular cytogenetics laboratory. Carcinomas with staining intensity scores of 3 are considered positive for over-expresslon of HER2/neu oncoprotein. Tumors in this category show an excellent correlation between the resuits of immunohistochemical and FisH testing, and almost always show. gene ampliflcation. Tho immunnnernxirdase stain(s) renorted above were developed and their performance characteristics determined by the. They have not been cleared or approved by the U. S. Food and Drug Administration. not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement. Amendments of 1988 ("CLIA") as qualified to perform high-complexity clinical testing.. Pathologist Electronically signed out on. _Specimen Class: Status: Signed Out Accessioned: Signed Out:  Pazc 4 of8
+
+--- Page 5 ---
+Surgical Pathology - Working Draft Pagc 5 of 8
+
+--- Page 6 ---
+Surgical Pathology. Working Draft Specimen Class: Status: Signed Out Accessione
+
+--- Page 7 ---
+Surgical Pathology . Working Draft  Page 7 of 8
+
+--- Page 8 ---
+Surgical Pathology  Working Draft END OF REPORT Page 8 of 8
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diff --git a/output/text/b8603bff-a399-4b51-8719-4c2ddab8bc2c.txt b/output/text/b8603bff-a399-4b51-8719-4c2ddab8bc2c.txt
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index 0000000000000000000000000000000000000000..20d8e9200d1edae4ae87cf1aded18ee8ead2b5e5
--- /dev/null
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+
+--- Page 1 ---
+SURGICAL PATHOLOGY MEDICAL RECORD SURGICAL PATHOLOGY PATHOLOGY REPORT Laboratory: Accession No. Submitted by: Date obtained: rd-6-3 Specimen (Received A.BASE OF LEFT RENAL TUMOR F.S Site O Biny N&5 Ci4.9 B.LEFT RENAL PERITUMOR FAT 1129|13 C.LEFT RENAL TUMOR BRIEF CLINICAL HISTORY: UUID:465C49A8-2050-434A-AC95-9144E46972DB TCGA-MH-A857-01A-PR PREOPERATIVE DIAGNOSIS: Redacted left renal mass OPERATIVE FINDINGS: POSTOPERATIVE DIAGNOSIS: left renal mass Surgeon/physician: PATHOLOGY REPORT Laboratory: Accession No. GROSS DESCRIPTION: A. The specimen is received fresh for intraoperative consultation and consists of a 1.2 x 0.4 x 0.3 cm tan-yellow irregular tissue fragment that is submitted in toto for frozen and permanent section in cassette FsA. FROZEN SECTION DIAGNOSIS: FsA. Base of left renal tumor, biopsy: - NO TUMOR SEEN B. The specimen consists of a 173 gm, 11.2 x 6.5 x 3.2 cm tan-yellow aggregate of fatty soft tissue partially surfaced by a tan-pink smooth glistening peritoneal surface. No discrete lesions are identified. Sectioning reveals a tan-yellow unremarkable fatty cut surface. Representative sections are submitted in cassettes Bl-B6. C. The specimen consists of a 54.7 gm, 5.5 x 5.2 x 3.8 cm partial nephrectomy specimen partially surfaced by a tan-brown scabrous renal resection margin. The capsular margin is partially surfaced by tan yellow lobulated fat. The renal resection margin is inked blue and the capsular margin is inked black.
+
+--- Page 2 ---
+The specimen is serially sectioned to reveal a 4.6 x 3.8 x 3.2 cm tan-yellow to brown to red variegated poorly demarcated mass that grossly extends less than 1 mm from the renal resection margin and 0.4 cm from the overlying Gerota's fascia/capsular margin. There is a minimal amount of uninvolved renal parenchyma at the renal resection margin. Representative sections of the majority of the mass, to include the. capsular and renal resection margins, are submitted sequentially in. cassettes C1-c17. (Please note that a representative portion is taken for MICROSCOPIC EXAM DIAGNOSIS: A. Base of left renal tumor, excision: - NO TUMOR IDENTIFIED B. Left renal peritumor fat, excision: - FIBROADIPOSE TISSUE, NO TUMOR IDENTIFIED C. Left renal tumor, partial nephrectomy:. - PAPILLARY RENAL CELL CARCINOMA  CHROMOPHOBE RENAL CELL CARCINOMA (SEE SYNOPTIC REPORT) SYNOPTIC REPORT: PROcEDuRE: Partial nephrectomy SPECIMEN LATERALITY: Left TUMOR SIZE: Greatest dimension:. 1.8 cm (chromophobe renal cell carcinoma) 1.6 cm (papillary renal cell carcinoma) TUMOR FOCALITY: Multifocal MACROsCOPIC EXTENT OF TUMOR: Tumor limited to kidney. HISTOLOGIC TYPE: Papillary renal cell carcinoma Chromophobe renal cell carcinoma SARCOMATOID FEATURES: Not identified TUMOR NECROSIS: Present HISTOLOGIC GRADE: G2 (papillary renal cell Carcinoma) Not applicable (chromophobe renal cell carcinoma). MICROSCOPIC TUMOR EXTENSION: Tumor limited to kidney MARgins: Margins uninvolved by invasive carcinoma (Closest margin: Papillary renal cell carcinoma 1 mm from capsular margin;
+
+--- Page 3 ---
+Chromophobe renal cell carcinoma 1 mm from renal. parenchymal margin) LYMPH-VASCULAR INVASION: Not identified PATHOLOGIC STAGING: Chromophobe renal cell carcinoma: pTl,pNx,pMX. Papillary renal cell carcinoma: pTl,pNx,pMX. cOmmENT: By immunohistochemistry the chromophobe Rcc is positive for CK7, and negative for cDi5, vimentin and 504s. The papillary Rcc is positive for 504s.  concurs with the diagnosis. Physician was notified at the. time of frozen section and via. on Immunohistochemistry Disclaimer: "This test was developed and its. performance characteristics determined by the at the It has not been cleared or approved by the U.s. Food and Drug Administration. The FDA has determined that such clearance or approval. is not necessary. This test is used for clinical purposes. It should not be regarded as investigational or for research. This Laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLiA-88) as qualified to perform high complexity clinical laboratory testing."
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diff --git a/output/text/b872ecdb-047a-4cb4-ae2b-07469c0b543e.txt b/output/text/b872ecdb-047a-4cb4-ae2b-07469c0b543e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e990759b2c822e5ab9b09b3d15e5457575e5cc4f
--- /dev/null
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+
+--- Page 1 ---
+Examination: Histopathological examination Examination No.. PESEL: XXX Age Gender: F Patient: XXX Material: Multiple organ resection - colon Unit in charge: Physician in charge:. Material collected on: Material received on: Expected time of examination: Clinical diagnosis:. Examination performed on: Macroscopic description: A 27 cm length of large intestine with periintestinal fat tissue sized 24 x 5 x 4 cm. Ulcerous tumour sized 1.8 x 1.5 x 0.7 cm in the mucosa. Microscopic description: Adenocarcinoma mucinosum Infdtratio carcinomatosa tunicae muscularis priopriae telae adiposae pericolicae. Incision lines free of neoplastic lesions. Lymphonodulitis reactiva NO xxII. Histopathological diagnosis  Adenocarcinoma mucinosum coli$Mucinous adenocarcinoma of the colon.  pT3, pNO) CONTACT YOUR DOCTOR WITH THIS REPORT!
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diff --git a/output/text/b8ca7d05-5e3f-4960-8ad9-3217b892eb86.txt b/output/text/b8ca7d05-5e3f-4960-8ad9-3217b892eb86.txt
new file mode 100644
index 0000000000000000000000000000000000000000..003f895d9bc9a984b1a9b06b2c471a72029f3224
--- /dev/null
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+UUID:F4F5C477-30BB-41EE-B188-B20DE019F30A -A80P-01A-PR Referring Physician: DOB: Age:' Gender:F Ref#: Hosp#: Patient Location: Case #: Date of Service: Date Received: Date Reported: FINAL SURGICAL PATHOLOGY REPORT Diagnosis: A. - E. RIGHT BREAST WITH AXILLARY SENTINEL LyMPH NODES, MASTECTOMY WITH SENTINEL LYMPH NODE BIOPSIES: - Invasive ductal carcinoma, Nottingham grade 2. - Invasive tumor nodule measures 18 mm in diameter. - Ductal carcinoma in situ (DciS), solid and cribriform architectural patterns, with associated comedo necrosis and calcifications. - Resection margins free of tumor.. - Tumor is present 15 mm from the nearest margin (medial-anterior- inferior). - Sites of previous biopsy identified.. - Six axillary sentinel lymph nodes, not tumor present (0/6). PATHOLOGIC TUMOR STAGING SYNOPSIS: Type and grade (invasive): Invasive ductal carcinoma, Nottingham grade 2. Type and grade (in situ): DCIS, nuclear grade 2. ID O 3 Primary tumor: pT1c. Regional lymph nodes: pN0(i-)(sn) arcerone,eufltotinoj deet Distant metastasis: pMX. $s00I 3 Pathologic stage: IA. Sute &y@ust Lymphovascular invasion: Not identified.. Margin status: Negative (R0). C50.9 t)417114 Case #: Page 1 This report continues... (FINAL) Printed:
+
+--- Page 2 ---
+Patient: Case # FINAL SURGICAL PATHOLOGY REPORT Breast Invasive Tumor Staging Information (AJCC Cancer Staging Handbook, 7th Ed, and CAP protocol, Oct 2009) This staging also incorporates: Previous biopsy: Breast profile: Total breast with axillary sentinel lymph nodes. Specimen type: Specimen procedure: Mastectomy with sentinel lymph node biopsies. Lymph node sampling:. Axillary lymph nodes (6 nodes in 4 specimens) Specimen integrity: Single intact specimen. Specimen laterality: Right. Specimen size: 21 x 15.5 x 4 cm. INVASIVE TUMOR FEATURES: Invasive tumor size: 18 mm. Invasive tumor site: Lower inner quadrant (3:30 aspect) Invasive tumor focality: Single focus of invasive carcinoma. Histologic type: Invasive ductal carcinoma. Total Nottingham Grade:. 2 of 3. 3 of 3. Tubule formation: 2 of 3. Nuclear Pleomorphism: 1 of 3. Mitotic count for Nottingham: Mitotic count: Three mitoses in ten high power fields. Lymphatic invasion: Not identified. MARGIN STATUS FOR INVASIVE COMPONENT: Negative (RO). 15 mm. Distance of tumor from margins: Closest margin: Anterior-medial-inferior (anterior margin overlying LIQ tumor) Other margins: Invasive carcinoma is at least 40 mm from all other margins. IN-SITU CARCINOMA (DCIS) FEATURES: DCIS extent: DCIS present in association with invasive carcinoma, and extends into surrounding tissue (DCIS is associated with calcifications, and therefore may correspond to area of mammographically detected calcifications) Pattern: Solid and cribriform. Nuclear grade: Intermediate grade.
+
+--- Page 3 ---
+FINAL SURGICAL PATHOLOGY REPORT Necrosis: Present. Calcifications: Present. Margin status for DCIS component: Negative. Distance of In-situ from nearest margin: DCIS is at least 15 mm from the closest anterior-inferior-medial margin. LOBULAR CARCINOMA IN-SITU (LCIS): Absent. Skin: Unremarkable. Nipple: Unremarkable. Skeletal Muscle: Not present. INVASIVE PATHOLOGIC TUMOR STAGING (pTNM) Primary tumor (pT): pT1c. Regional lymph nodes (pN): pN0(i-)(sn). Distant metastasis (pM): pMX. Pathologic Stage: IA RECEPTOR STATUS AND HER2/NEU: Estrogen receptors: POSITIVE (98% positive cells, strong) Progesterone receptors: POSITIVE (15% positive cells, strong) Her2/neu: Not overexpressed (IHC score 1+). Ki-67 proliferative index: 20% positive cells. gned Source of Specimen: A. Right axillary sentinel lymph node B. Right axillary sentinel lymph node C. Right axillary sentinel node D. Right axillary sentinel lymph node E. Right Breast Clinical History/Operative Dx: Right breast cancer Intraoperative Diagnosis: A. Right axillary sentinel lymph node No tumor cells present. (Dr. ,. The intraoperative interpretation(s) was/were performed and rendered at 11/35/13 Case #: Printed:
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diff --git a/output/text/b907a63a-7957-4104-9dc0-1a5cd7a53985.txt b/output/text/b907a63a-7957-4104-9dc0-1a5cd7a53985.txt
new file mode 100644
index 0000000000000000000000000000000000000000..aa572346934faaddd622c1724d27866349704a01
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+--- Page 1 ---
+TCGA-B9-4115 SURGICAL PATHOLOGY Surgical Pathology Report. Accession #: Diagnosis: Kidney, right, nephrectomy Histologic tumor type/subtype: renal cell carcinoma, papillary subtype Histologic grade (if applicable: Fuhrman grade 3(of 4) Tumor size (greatest dimension): multifocal,largest tumor nodule 4 cm in greatest dimension Extent of tumor invasion: Capsular invasion/perirenal adipose tissue: not identified Gerota's fascia: not identified Renal vein: not identified Ureter: not identified Venous (large vessel): not identified Lymphatic small vessel): not identified Histologic assessment of surgical margins: Perirenal adipose tissue: negative for malignancy Gerota's fascia: negative for malignancy Renal vein: negative for malignancy Renal artery: negative for malignancy Ureter: negative for malignancy Adrenal gland: not present Lymph nodes: not identified Other significant findings: mildglomerulo- and arteriolonephrosclerosis with interstitial fibrosis with
+
+--- Page 2 ---
+focal chondrous metaplasia. AJCC Staging: pTla pNx pMx This staging information is based on information available at the time of this report, and is subject to change pending clinical review and additional information. Clinical History: with a bilateral renal mass. Gross Description: Specimen fixation: formalin Type of specimen: nephrectomy, unspecified Side of specimen: right Size and weight of specimen: 950 grams; The specimen in its entirety is 24 x15 x 6.5 cm.The kidney is 11.5 x7 x7 cm. Orientation: The superficial surface surrounding the tumor is inked blue. Presence/absence of adrenal gland: absent Tumor description/site: There are multiple cortical tumor nodules. The largest is superior and midline. There are three other smaller tumor nodules scattered about the renal cortex. These nodules are mostly superior. Tumor size: There are multiple tumor nodules present, the largest measures 4 x 3.8 x 3.0 cm.The second largest measures 3.5x 2.8 x2.0 cm. Multiple smaller nodules are also found. These are scattered throughout the renal parenchyma. Presence/absence of multicentricity: present, at least 6 Confinement/non-confinement to the kidney: Extending through the renal capsule.
+
+--- Page 3 ---
+Extent of invasion: Perirenal adipose tissue: tumor grossly involves Gerotas fascia: not present Renal vein: does not involve Ureter: does not involve Other organs: n/a Surgical margins: Perirenal adipose tissue: positive Renal vein: negative Renal artery: negative Ureter: negative Description of kidney away from tumor: The kidney is pink/brown. There is a distinct corticomedullary junction. The cortex measures approximately 0.9 cm while the medulla measures approximately1.2 cm. Lymph nodes hilar): The hilar area is palpated and no lymph nodes are found. Other significant findings: none Tissue submitted for special investigations: tumor and normal are submitted to Tissue Procurement Digital photograph taken: not taken Block summary: Al-vascular, ureteral margins A2- tumor extending out of capsule A3- tumor extending out of capsule in area of renal sinus A4 -tumor with adjacent normal tissue A5 - perinephric fat firmly adherent to tumor A6 additional tumor adherent to perinephricfat with blue ink margin A7- tumor nodule A8 - separate tumor nodule A9 tumor from largest nodule A10 perirenal fat A11 separate tumor nodule A12 normal kidney - A13 - hilar fat adjacent to hilar structures Al4 -tumor at hilum
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diff --git a/output/text/b925d774-e413-4878-a7b1-7fa4230080fc.txt b/output/text/b925d774-e413-4878-a7b1-7fa4230080fc.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d1648d49e5cf1e8e06dde684f710c8515b254ab6
--- /dev/null
+++ b/output/text/b925d774-e413-4878-a7b1-7fa4230080fc.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:4979AF79-CF92-4D6C-87FD-158C87B5F059 TCGA-2Y-A9GV-01A-PR Redacted Pathology Report Genderx. Seryice: Recelved Reparted: Submitting Physicians: ID-03 Additlonai Pnyascians Pathologist: Crcincrno, heestoeelluler NsS Intraop.ratnoiog:st Pertorming Physcian 8170/3 CLINICAL HISTORY Sit: sLeier CaQ.D NONR GIVEN. PRROPEEATIVE DIAGNOGIS: HEPATOMA RIGHT LODE OF LIVEA. A J 4/Q8/1y SFECIMEN TYPEIS!: AzGALLLADDER. B: DIAPHRAGMATIC NODULE F5 SESMENT5.6 FANAL DLAGNOSIS: A. CALLBLADDER Benign galibiaater waix with miid rocal cnron:c inflammation. No evidence ot salignancy DEAPHRAGXATIC NODULE: Finroadipoae tlesue with s tocus or tat.necros:s and rocal. dyetroprig alciricatton. No evidence bt salignancy C. LVEE, SEGMENT S AND6,RRSECTION Hell dirterentlated nepatoceilular carcinoma, clear cell pattarn. umor s1zet 6.5x5x42cm. Hstoioggrade grada I weldirterentiated Inxedparenchynal rcaection msrgin: Eree or carcirca Nenneop:sstic 1ver tlasuet rortal ctixonic inslammatory inrilLrae consistent witn cnangea:in the vic:nityor the curor masa thore is no svi tence ot backgrsund cirrhosis presert. tha attenaing pathologist, parsonaliy. revtawel the.entare pathlogy case ans rencered tr.c rinal n:agnosia. Hlectrcnicaly signed dut ty OTHR AELATED CLINICAL LATA NA INTRAOPERATIVS DLAGNOSES FROZEN SECTION AND GROSS DIAGNOSIS A. GALLSLADDER: Tumor grosaly 1.3 cm auay tron nargin. umor 6.5.cm. FSB. DAFRRAGXATIC NODJIE: Benign, conaiatent witn rat recrosia
+
+--- Page 2 ---
+CCMMENr Tnis trczen section Jsgnoaia/zesuit in nave perrormen the intrsoperative. consulcatsone ang 1seued the arove diagnosis. GRCSS DESCRIPTION: The: specimen is raceivos Sxean and lateled "galibladder": The apecinen consists. containa green B:leard galistones are not present. The galiniadder.wsll ia rine, aubmitted to Tiasua Prccurament Laboratory. Representative aecttora are suraitted. Custic duct, Langentiai. A2: The specimen, is receivas.tresn and lareled *a:apnragrat ic rolule', Theapecimer ccnsiats ot a tragnent sr eort, tanwniteto Laxyelncw tiasue meaeuring s xos x O.z cm. Tna spndimen was also entirely submitted aa. Fsne.. Thespecimen is received :rean and Jabeled geyments s and 6* The specimen cnit 0ta.279. gra15x1.5x6cirdark. red brcwn scgent or liver he specimen in serialysecticnad to reveal an trregular, tan-wnite to tan-yellow partially nemorrnagic ncdulereaauring 6.5 x5 x.2.cm.Jocatedat1.2.corrom. Maxgin cl resection. Tme marg:n or resesrion is Arrequiar and is entirely Inked in. biacK. The resainirg hepatie parerchyms 1a dark red-trown witn lobuiar aapects. Representative frosh tieaue.is submicted to rrssue Procurement Laboratory Representative seccions are autaitted'as rolicws Perpenaicular section. leaion in relaticn to: ciosesc inked aurgical. marginoc.resection C2 -C7 t Leslon NormalIrerparenchyma. W 1014 Ye Diagnosis Discrepancy HIPAA Discrepar Dual/Synchronous ase is (circle
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diff --git a/output/text/b9475d9b-c8f8-49aa-b461-083c2606254f.txt b/output/text/b9475d9b-c8f8-49aa-b461-083c2606254f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..de9200b8c5cd3ae3c6e6ea858d0eb1fd9bb72ead
--- /dev/null
+++ b/output/text/b9475d9b-c8f8-49aa-b461-083c2606254f.txt
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+
+--- Page 1 ---
+I Path (First Tumor) Tumor Site: Hepatic Flexure Proximal  Date of Cancer Sample Procurement: Histology: Adenocarcinoma Description of other histology: Grade: Well Differentiated  Yes Mucinous: C No C Yes r Unknown (Focal)  Yes Signet Ring Feature:  No r Yes  Unknown (Focal) Histologic Heterogeneity: 6 No r Yes C Unknown Host Response: Lymphoid Aggregates Crohn's like reaction  None  Yes C Unknown Plasma cell rich stroma r No r Yes C Unknown  Expansile Growth Pattern:  Expansile ( Invasive r~ Unknown  and Invasive Inflammatory Bowel Disease 6 No r Yes  Unknown Angiolymphatic Invasion:  No r Yes C Unknown Mutator Phenotype: 6 No ( Yes r Unknown Number of Slides 1 C Yes Garland Necrosis present: r No  Yes C Unknown (Focal) TIL Cells / HPF 2 Pathologist Comment: Jcs-o-3 adirocarcriorrs /nucions, N0s 8y8of3 UUID:F38C6493-985D-48EC-81AB-B79CF6BD89A7 Site: hepatr flexure C18.3 TCGA-DM-A282-01A-PR Redacted hs 5/3/1 asn is (circl
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diff --git a/output/text/b94db039-e403-4788-8ac0-8da76b33fc8e.txt b/output/text/b94db039-e403-4788-8ac0-8da76b33fc8e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9ea2a4a939baf3e10b7920ffe32334ccfa2cd85a
--- /dev/null
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+
+--- Page 1 ---
+Sffieer loug Bcell Lyynphorro 968d/3 Tumor ID # Date of Surgery: Sute: BramSten c717 Ot bf28/13 Microscopic Description:. Sections demonstrate sheets of poorly cohesive, large cells. These have large atypical, somewhat open nuclei, usually with multiple nucleoli. They have only a modest amount of cytoplasm. Numerous mitotic figures are seen. Individual apoptotic cells are seen without frank necrosis. The tumor has an expansive interface with the surrounding parenchyma but an angiocentric pattern is also appreciated. Areas of apparent glial and fibrous scarring are also noted. Diagnosis: Brainstem Tumor: diffuse Large Cell Lymphoma, B-cell type UUID: B40907C0-DA7B-436F-993A-53DA4C9A56A9 TCGA-RQ-A68N-01A-PR Redacted
+
+--- Page 2 ---
+ANATOMIC PATHOLOGY REPORT PERMANENT CHART COPY NEUROPATHOLOGY REPORT GROSS DESCRIPTION:S MICROSCOPIC DESCRIPTION: 1, 2. Sections demonstrate sheets of poorly cohesive, large cells. These have large atypical, somewhat open nuclei, usually with multiple nucleoli. They have only' a modest amount of cytoplasm. Numerous mitotic figures are seen. Individual apoptotic cells are seen without frank necrosis. The tumor has an. expansive interface with the surrounding parenchyma but an angiocentric. pattern is also appreciated. Areas of apparent glial and fibrous scarring are also noted.. The neoplastic cells are imnunoreactive for cD45 and cD20, confirming B-cell. lymphocytic origin. They are negative for Grap, S-100 and cytokeratin 8/18. The neoplastic cells demonstrate aberrant expression of the T-cell marker cD43. but are negative for cD3 and cD45 ro. They demonstrate BcL2 and BCL6 positivity but are negative for cdio. Overall, the immunophenotype is consistent with a diffuse large cell B-cell lymphoma. DIAGNOSIS: (PROVISIONAL) : 1. 2. BRAINSTEM TUMOR, BIOPSIES: DIFFUSE LARGE CELL LYMPHOMA, B-CELL TYPES for c03 Censis teat CD45 ro,  Iya fhsmo. B-ce!/ W:+l a
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diff --git a/output/text/b96d89a1-bd12-43e3-898a-2ce59dc747e0.txt b/output/text/b96d89a1-bd12-43e3-898a-2ce59dc747e0.txt
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index 0000000000000000000000000000000000000000..a13d18d5d24380bb4e291fd19a1b362b9d422fa9
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+
+--- Page 1 ---
+UUID: 2D2E6687-CD36-42F1-A091-7B249A2FAFF6 TCGA-GS-A9TW-01A-PR Redacted AXILLAR LYMPH NODE : We receive three tissue fragments of pinky color, the biggest of 2,7x2x0,8. cm, and the smallest of 1,5x1x1 cm. AXILLAR LYMPH NODE, EXCISION: - PRIMARY MEDIASTINAL DIFFUSE LARGE B CELL LYMPHOMA The architecture of the lymph node shows a large cell lymphoma with a diffuse growth pattern, with cells of an anaplastic morphology and sclerosis.. The immunophenotypic study shows that the neoplastic cells are positive for CD20, CD79a, BOB1, OCT2, BCL2 and BCL6 with moderate and hetereogeneous expression of CD30, and are negative for CD10, CD3, CD5 and CD15. In situ hybridization for the RNA of the Epstein- Barr virus. (EBER) is negative. The Ki-67 proliferative index is 90%. 968/3 S:te xyy/i nude,axIla 0773 VI3/3i|1 4 13/+3/2013
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diff --git a/output/text/b96d91d9-5bac-458a-bfe7-480ec98e2268.txt b/output/text/b96d91d9-5bac-458a-bfe7-480ec98e2268.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f72e3cb52efe313c0482ba944a7b7199121e1ac6
--- /dev/null
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+
+--- Page 1 ---
+inical Diagnosis & History: y/o female with left breast Idc and bcis, now for segmental resection and SLNB. Specimens Submitted: 1: Sp: s Sentincl node #1. level 1, left axilla (fs). 2: SP: Sentinel node #2. level 1, left axilla. 3: Sp: Sentinel node #3, level 1. left axilla 4: Sp: 5: SP: Left axillary contents levels 1, 2 and 3. 6 SP: Additional level 3 nodes, left axilin. SP: Left breast mammographic mass 7: DIAGNOSIS: 1) LYMPH NODE, SENTINEL #1 LEVEL I LEFT AXILLA BIOPSY: - METASTATIC MAMMARY CARCINOMA IN ONE OF ONE LYMPH NODE (1/1). . EXTRANODAL EXTENSION IS PRESENT (>2 MM).) 2) LYMPH NODE, SENTINEL #2 LEVEL I LEFT AXILLA; BIOPSY:  ONE BENIGN LYMPH NODE (O/1) WITH A TUMOR EMBOLUS IN PERINODAL LYMPHATIC VESSEL. 3) LYMPK NODE, SENTINEL #3 LEVEL I LEFT AXILLA; BIOPSY: ONE BENIGN LYMPH NODE (O/1). 4) LYMPH NODE, SENTINEL #4 LEVEL I LEFT AXILLA; BIOPSY: - ONE BENIGN LYMPH NODE (O/1). G 5) AXILLARY CONTENTS, LEFT LEVELS I, II AND III; DISSECTION: LEVEL I: A MICROSCOPIC FOCUS OF METASTATIC MAMMARY CARCINOMA IN ONE OF THREE LYMPH NODES (1/3). - LEVEL II: EIGHTEEN BENIGN LYMPH NODES (O/18) . nftt/ol - LEVEL III:  SIX BENIGN LYMPH NODES (0/6). 6) LYMPH NODE, ADDITIONAL LEVEL III LEFT AXILLA; EXCISION: - BENIGN ADIPOSE TISSUE WITH MICROSCOPIC LYMPHOID AGGREGATES. SON 7) BREAST, LEFT; /EXCISION: - MULTIPLE FOCI OF INVASIVE DUCTAL CARCINOMA. NOS TYPE, HISTOLOGIC . Continued on next page ** b'050 gnq :f!5 3 -0-071
+
+--- Page 2 ---
+GRADE II-III/III, NUCLEAR GRADE II/III, RANGING IN SIZE FROM O.i CM UP TO 2.5 CM (THE TWO LARGEST FOCI OF TUMOR MEASURE 1.4 CM AND 2.5 CM GROSSLY). - A FEW FOCI OF DUCTAL CARCINOMA IN SITU (DCIS). SOLID AND CRIBRIFORM TYPES WITH INTERMEDIATE NUCLEAR GRADE. - NO CALCIFICATIONS ARE IDENTIFIED IN EITHER THE INVASIVE OR IN SITU COMPONENT. - PROMINENT VASCULAR INVASION IS PRESENT. - INVASIVE CARCINOMA EXTENDS TO THE FOLLOWING SHAVED MARGINS: LATERAL (IN 1/8 SLIDES. C.6 CM): INFERIOR (IN 3/8 SLIDES. THE LARGEST FOCUS MEASURING 0.8 CM); ANTERIOR (IN 4/19 SLIDSS. THE LARGEST FOCUS MEASURING O.S CM); AND POSTERIOR (IN 1/1S SLIDES. THE LARGEST FOCUS MEASURINC 0.2 CM). IN ADDITION, LYMPHATIC TUMOR EMBOLI ARE ALSO SEEN AT THE MARGINS. - NO INVOLVEMENT OF THE SURGICAL MARGINS BY DCIS IS IDENTIFIED. - BIOPSY SITE CHANGES -RESULTS OF SPECIAL STAINS (ER, PR, HER-2/NEU) WILL BE REPORTED AS AN ADDENDUM. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATICN OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. ** Roport Electronically Signed Out * Special Studies: Result Special Stain RECUT Comont RECUT RECUT RECUT NEG CONT IMM RECUT ER-C pR-c HER2-C NEG-HER2 Gross Description: 1) The specimen is received fresh for froren section consultation labcled, *sentinel aode #1, level 1. left axillar, and consists of a piece of yellow-tan fatty tissue measuring 3.5 x 2 x 1 cm, containing firm gray lymph node measuring 1.4 x 1 x 0.7 cm. Representative section is frozen. The remainder of the specimen is entirely submitted. Summary of Sections: Fsc froxen section control U . undesignated ** Continued on next paga 1.
+
+--- Page 3 ---
+2) The specimen is received in formalin, labeled, -Sentinel node #2. level 1, left axilla". It consists of a 0.9 x 0.5 x 0.4 cm tan lymph node with attached adipose tissue.. The entire lymph node is submitted.. Summary of Sections: LN - lymph node 3 The specimen is received in formalin, labeled, -Sentinel node #3, level I, left axilla". The lymph node is entirely submitted.. It consists of a 1.3 x 0.4 x 0.3 cm tan lymph node. Summary of Sections: LN - lymph node 4) The specimen is received in formalin, labeled, *Sentinel node #4. level 1. left axilla". It consists of a 0.3 x C.3 x 0.2 cm tan lynph node with attached adipose tissue. The lymph node is entirely submitted. Summary of Sections: LN - lymph node 5) The specimen is received in formalin, labeled, rLeft axillary conterts levels 1, 2 and 3 (with tags attached)*. It consists ot 3'17.0 x 15.0 x 4.0 cm fragmont of adipose tissue with metallic tags labeling levels 1 chrough 3. Multiple lymph nodes are identified within each level, measuring from 0.2 to 2.3 cm in greatest dimension. All identified Iymph nodes are submitted. Surmary of Sections: LIBLN 'level one bisected lynph node LILNSS  level one. one lymph node serially sectioned LII level two lymph nodes LIII level three iymph nodes 6) The specimen is received in formalin, labeled. *Additional level 3 nodes , left axilla". adipose tissue. It consists of a 2.0 x 1.8 x 1.0 cm aggregate of No definite lymph nodes are identified.. submitted. Entirely Swnmary of Sections: U - undesignated 7) The specimen is received fresh, labeled. "Left breast mammographic mass (short stitch superior, long stitch lateral)". It consists of a 9.5 x ** Continued on next page **.
+
+--- Page 4 ---
+8.0 x 5.3 cm fragment of fibroadipose tissue with a needle localizing wire and sutures marking tbe superior and lateral margins.. -- Page 4 of 6. as follows: black-anterior and posterior, yellow-superior, green-inferior, blue-lateral. red-medial.  The specimen is inked There is a palpable mass at the lateral/inferior portion of the specimen. The margins are entirely shaved and submitted. Seraal sectioning reveals a 2.5 x 2.0 x 1.8 cm firm white stellate mass, margin.  Noted adjacent to this mass, near or close to the medial margin is a second tan firm nodular mass, measuring 1.4 x 1.1 x 0.9 cm.. breast parenchyma is predominantly fatty with foci of fibrous tissue. other lcsious are ideatified..  The remaining. Portions of both the larger and smaller tumors are submitted for tps. Representative sections are submitted. NO Sunmary of Sections: M medial lateral inferior anterior superior P posterior LT larger tumor. ST smaller tumor ADJ  adjacent to tumor mass RS representative sections. Suumary of Sections:. Part 1:  SP: Sentinel node #1, level 1, left axilla Block Sect. Site rt r PCs fsc u 1 1 Part 2: SP: Sentinel node #2, level 1, left axilla. Block Sect. Site 1 PCS ln 1 Part 3: SP: Sentinel node #3. level 1, left axilla. Block Sect. Site PCs 1 1n 1 Part 4: SP: Sentinel node #4, level 1, left axilla. Block Sect. site 1 PCs In 1 Part 5:  SP: Left axillary contents levels 1, 2 and 3. Block Sect. Site pCs * Continued on next page **.
+
+--- Page 5 ---
+LIBLN yage 5 of 6 5 LII LIII 10 LILNSS 6 Part 6: SP: Additional level 3 aodes. left axilla Block Sect. Site PCs u Part 7: 1 SP: Left breast manmographic mass Block Sect. Site 19 PCs 2 a adj 19 8 i  2 4 1t *9 15 m p rs 15 5 2 : 10 2 Procedures/Addenda: Addendum Date Ordered: Date Complete: Status: Date Reported:  Signed Out By: Addendum Diagnosis ADDENDUM REPORT SITE:LEFT BREAST (PART #7) ER:  9S% NUCLEAR STAINING WITH MODERATE INTENSITY PR:  40 NUCLEAR STAINING WITH WEAK TO MODERATE INTENSITY HER-2/NEU (HERCEPTEST):  POSITIVE (STAINING INTENSITY OF 3+) Intraoperative Consultation: Note:  The diagnoses given in this soction pertain only to the tissue sanple examined at the time of the intraoperative consultation. * Continued on next page **
+
+--- Page 6 ---
+FROZEN SECTION DIAGNOSIS: Page 6 PERMANENT DIAGNOSIS: METASTATIC CARCINOMA. SAME End of Report.
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diff --git a/output/text/b979c03c-9539-4791-b08f-7262255b9892.txt b/output/text/b979c03c-9539-4791-b08f-7262255b9892.txt
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index 0000000000000000000000000000000000000000..cf963bc38d5587ca419a04507b7d41f0b3ba11a4
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+
+--- Page 1 ---
+Patient Name: Sex: Female TcD-o-3 UUID: 4C775CF4-39D7-4246-87A4-4659783A1C18 Carcinomo,adreraI cor+icaJ 8376J3 TCGA-0R-A59-01A-PR  Redacted Site BAdrerob 6 land,csrtex C74 D Fe 1/3d)3 Macroscopy One vessel containing a material immersed in formaldehyde solution, described as following: product of resection of right adrenal mass, weighting 316 g and measuring 11 x 9 x 6.5 cm. The mass is. involved by a thick brown capsule. The cut surface is characterized by a multinodular appearance, with. some areas of a light brown color and some areas of hemorrhage friable consistency. The remaining adrenal parechyma is evident and measures 1.5 x 1.0 cm. The surgical margins were stained with green indian ink. Conclusion: Product of right adrenalectomy and right adrenal mass resection: Adrenocortical carcinoma with the following features:. .Largest diameter -- 11 cm.  Nuclear grade (Fuhrman) -- 3 Diffuse architectural pattern - present Clear cells in < 25% of the neoplasm -- present Areas on necrosis -- present Mitotic count -- 6 in 50 H.P.F. Atypical mitosis -- absent Capsular invasion - not detected .Venous invasion -- not detected Sinusoidal invasion -- present
+
+--- Page 2 ---
+WEISS SCORE = 6 . Periadrenal fatty tissue without evidence of neoplastic infiltration W4
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diff --git a/output/text/b979e3f7-3f83-405a-b12c-937a626af88d.txt b/output/text/b979e3f7-3f83-405a-b12c-937a626af88d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..50aa7d01b965ba9a710d8697b63b4c23de9cfa2d
--- /dev/null
+++ b/output/text/b979e3f7-3f83-405a-b12c-937a626af88d.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+OLOGY REPORT DIAGNOSIS: A.Deep margin left renal mass,biopsy with frozen section Benign renal parenchymanegative for malignancy. Frozen section diagnosis confirmed. B.Left renal mass, partial nephrectomy Tumor Characteristics: 1.Histologic type:Papillary renal cell carcinoma, solid variant. Tumor siteLeft kidney 3.Tumor focality:Unifocal. 4.Tumor size2.5x2.2x2.0 cm. 5.Macroscopic/microscopic extent of tumor: Tumor is confined to kidney. 6.Nuclear grade: Fuhrman grade 2/4. 7. Lymphovascular space invasion: No. 8.Sarcomatoid features:No. Surgical Margin Status: 1.Resection margins are free of carcinoma. However, one focus of tumor extends into,but not through the capsule and is within O.5 mm of an inked margin Lymph Node Status: Not applicable. Other: 1. Other significant findings: Non-neoplastic renal tissue with no pathologic findings. 2.pTNM stageT1a Nx Mx. COMMENTS: The neoplasm consists of mostly a solid pattern with focal papillary architecture at the peripheryand also contains a proliferation of foamy histiocytes within the tumor. Rare psammoma bodies are seen within the tumor.These features are most consistent with a solid variant of papillary renal cell carcinoma For CLINICAL INFORMATION CLINICAL HISTORY: Preoperative Diagnosis: Renal and ureteral disease NOS Postoperative Diagnosis Symptoms/Radiologic Findings: SPECIMENS: A.Deep margin left renal mass B.Deep renal mass SPECIMENDAT GROSS DESCRIPTION A. The container is received labeled eep margin left renal mass.The specimen consists of a piece of gray-tan to yellow-tan soft tissue,0.6 x 0.5 x 0.3 cm.The specimen was examined at the time of surgery and the frozen section is subsequently entirely submitted in a single cassette labele B.The container is received labeled 1, leit renal mass.The specimen consists of a wedge section of kidney measuring 5.0 x 3.0 x 2.2 cm. The soft tissue margin is inked.On secuioningtnere is a circumscribed gray-tan mass measuring 2.5 x 2.2 x 2.0cmthat comes within 0.1 cm of the inked soft tissue margin.Received with the specimen are two cassettes, one green and one yellow labeled with the yellow additionally labeled-16 and the green additionally labeled-17.Representative sections are submitted in four cassettes
+
+--- Page 2 ---
+INTRA-OPERATIVE CONSULTATION: FROZEN SECTION DIAGNOSIS:Negative for malignancy
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diff --git a/output/text/b9a2fae4-0752-40b5-9740-d94a4324ee0d.txt b/output/text/b9a2fae4-0752-40b5-9740-d94a4324ee0d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..89d4743ceda117c31d31493654b6df4ce3a3de1e
--- /dev/null
+++ b/output/text/b9a2fae4-0752-40b5-9740-d94a4324ee0d.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:8EBDD431-36DB-4197-B4BA-A6F212CAC1C1 TCgA-V4-A9E5-01A-PR Redacted Date of surgery :. Right eye enucleation Macroscopy The eye ball measures 23 by 23 by 23 mm with a posterior segment of optic nerve of 10 mm .At the section, the tumor measures 14 mm main line. Samples have been made for cryo preservation, cytogenetic studies and for the preclinical investigation laboratory. The specimen has been then included entirely Microscopy The tumor seen macroscopically corresponds to a choroidal melanoma entirely made of fusiform cells. Tumor cells are tangled in short bundles. Some of them contain melanin pigment. Nuclei of the tumor cells are fusiform, ovoid with sometimes marked anisocaryosis. The mitotic index is low with 4 mitosis out of 10 high 400 magnification fields. The tumor is developed close to the ciliary processes ( slide C) and infiltrates the very superficial internal layers of the sclera. The optic foramen, the optic nerve and its cut end are free of tumor. The meningeal sheaths as well as the anterior chamber are free. Conclusion Choroidal melanoma of the right eye Fusiform cell type predominant Size of the tumor: 14 mm Infiltration of the internal superficial layers of the sclera Optic nerve free of the tumor on all its length, including the posterior end Anterior chamber and meningeal sheaths free L00.3 CeanwnNoS S730/3 (RC)wriel Cb9.3
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diff --git a/output/text/b9dd4fd6-c4f5-444c-b11c-5e23652fb947.txt b/output/text/b9dd4fd6-c4f5-444c-b11c-5e23652fb947.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e0241dfaf66ab3f27cc0229884dfda2af5ca6c2a
--- /dev/null
+++ b/output/text/b9dd4fd6-c4f5-444c-b11c-5e23652fb947.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+breast SURGICAL PATHOLOGY Case Number /cs-0-3 Carcioma, inflfratmg ctuctl nos 850of3 Sit: brst, uqpw ontw gusdrent C50.4 Pat Diagnosis: A: Lymph node, right sentinel #1, removal. C$cF c5o.9 1/31/1 - Metastatic carcinoma present in one of one sentinel lymph nodes (1/1). Size of largest metastatic focus: Estimated at greater than 2.0 cm (see comment) Extracapsular extension: Present B: Lymph node, right axillary palpable, biopsy - Metastatic carcinoma present in three of three non-sentinel lymph node (3/3). Size of largest metastatic foci in each node: 9 mm; 4 mm; 0.22 mm. Extracapsular extension: Present. - Lymphovascular space invasion is identified in perinodal adipose tissue. C: Breast, right posterior margin, biopsy. Skeletal muscle and adipose tissue without diagnostic histopathologic change UUID:6EB1A616-E99C-4AF6-9C0A-0FDC521A79CD  No carcinoma in situ and no invasive carcinoma identified TCGA-AQ-A1H3-01A-PR Redacted D: Breast, right, total mastectomy Tumor type: Infiltrating ductal carcinoma. Nottingham combined histologic grade: 1. Tubule formation score: 2 Nuclear Pleomorphism Score: 2 Mitotic count score: 1 Focality of tumor: Muiltifocal and multicentric. Tumor size (greatest dimension): 3.7 cm (gross measurement, see comment) Lymphovascular invasion: Present In Situ Component: Present Situ Component type/Architecture pattern: Ductal carcinoma in situ, solid and cribriform types In Situ Component nuclear grade: Intermediate grade (nuclear grade 2)
+
+--- Page 2 ---
+In Situ Component necrosis: Comedo-type necrosis is present In Situ Component extent/size: Ductal carcinoma in situ comprises approximately 20% of the tumor volume. A precise span for the DCiS cannot be determined, however, DCiS is present in seven of eighteen tissue sections evaluated. predominantly in the vicinity of the invasive ductal carcinoma. Extensive intraductal component: Not identified Nipple involvement: Not identified Skin involvement: Not identified Margin status: Invasive component: Negative. Invasive carcinoma is greater than 5 mm from all margins.. In Situ component: Negative. DCiS is greater than 5 mm from all margins. Axillary lymph nodes (see also parts A, B, and F): Total number with metastasis: 14 (includes two lymph nodes with micrometastases) Total number examined: 23 Size of largest metastasis: estimated at greater than 2.0 cm (part A) Extracapsular extension: Present Microcalcifications: Focally present in association with ductal carcinoma in situ and with columnar cell change. Other findings:. - Atypical lobular hyperplasia - Flat epithelial atypia. - Sclerosing adenosis. - Apocrine cysts and apocrine metaplasia - Fibrosis and hemorrhage in keeping with prior biopsy site - Skin without diagnostic histopathologic change AJCC PATHOLOGIC TNM STAGE: pT2(m) pN3a Note: This pathologic stage assessment is based on information available at the time of this report, and is subject to change pending clinical review and additional information. E: Lymph node, right Level 3 axillary, removal - Metastatic carcinoma present in two of two lymph nodes (2/2). Size of largest metastatic foci: 6 mm; 5 mm Extracapsular extension: Not definitively identified F: Lymph node, right axillary Level 1 and 2, regiona! node dissection. - Metastatic carcinoma present in eight of seventeen lymph nodes (8/17) Size of largest metastatic focus: 12 mm Extracapsular extension: Present Note: In one lymph node, the metastatic focus measures only 0.2 mm (micrometastasis).
+
+--- Page 3 ---
+- Lymphovascular space invasion is present. Comment: Ithough the gross description mentions Mass A and Mass B, histologic sections of intervening tissue shows patchy involvement by ductal carcinoma in situ and invasive ductal carcinoma. Mass A and Mass B are therefore regarded as a single mass with a largest measurement of 3.7 cm (stage pT2). Multiple additional smaller foci of invasive carcinoma are. present, which are greater than grossly distinct from the large mass, including one nodule of invasive carcinoma identified in a separate (lower outer) quadrant (multifocal and multicentric disease).. Intraoperative Consult Diagnosis:. A frozen section was requested by Dr.. FSA1: Sentinel lymph node #1, right axilla, sentinel node biopsy. - Positive for metastatic carcinoma.. Frozen Section Pathologist: Clinical History: with right breast IDC, well differentiated, undergoing lumpectomy with axillary node dissection. Gross Description: Received are six appropriately labeled containers. Container A is additionally labeled "right sentinel node #1." It holds a 6 x 3 x 1.4 cm fragment of red/tan fibrofatty tissue containing a 5 x 1.5 x 1.3 cm lymph node candidate from which two representative sections are frozen as FSA1. The. remaining lymph node tissue is submitted in blocks A1-A4. Fat remains in formalin. Container B is additionally labeled "right axillary palpable node." it holds a 4.5 x 4.0 x 1.2 cm red/tan fibrofatty tissue. fragment containing three lymph node candidates measuring 3.5 x 3.0 x 1.0 cm, 0.6 cm and 0.4 cm. The two smaller Iymph node candidates are submitted in block B1. The largest lymph node candidate is sectioned and submitted in blocks B2 and B3. Fat remains in formalin.. Container C is additionally labeled "right posterior margin, clip posterior." It holds a 1.8 x 1.5 x 1.3 cm markedly cauterized fragment of yellow/gray fibromuscular tissue and fat. There is a clip present on one surface which is inked blue and the opposite surface is inked black. The specimen is sectioned and entirely submitted in blocks C1-C2, Container D is additionally labeled "right total mastectomy, stitch marks axillary tail." Specimen fixation: formalin Time in fixative: 9 hours ype of mastectomy: total mastectomy Weight of specimen: 900 grams.
+
+--- Page 4 ---
+Size of specimen: 26.6 x 21.2 x 6.3 cm Orientation of specimen: Anterior=blue, posterior-black, axillary tail=yellow Skin ellipse dimensions: 22.6 x 9.1 cm Nipple/areola: 1.7/5.0 cm Axillary tail: submitted separately Biopsy site: not identified Discrete Mass(es): present Number of discrete masses: two (designated A and B) Size of mass (es)/biopsy site: Mass A: 1.8 x 1.3 x 1.1 cm Mass B: 1.1 x 1.1 x 0.6 cm Location of mass(es): Mass A: upper outer quadrant (1A) Mass B: The mass is located 1.8 cm posterior and inferior to the lateral edge of Mass A. Distance of mass/biopsy site from surgical margin: Mass A: The mass is located 3.3 cm from the black inked deep margin, 1.5 cm from the closest blue inked soft tissue margin, 11 cm from the medial margin, and 10 cm from the lateral margin. Mass B: The mass is located 0.8 cm from the black inked posterior margin, 4 cm from the closest blue inked anterior margin.. Gross involvement of skin or fascia/muscle by tumor: absent Description of remaining breast: composed of dense and nodular white/tan fibroconnective tissue encompassing the mass; this is most prominent in the central/subareolar portion of the breast where there is dense blue dye staining The breast tissue between Mass A and Mass B is firm and hemorrhagic with fat necrosis. Sections are taken of the intervening parenchyma (D3 and D4). If Mass A and Mass B are contiguous, the overall measurements of the lesion would be 3.7 x 3.1 x 3.0 cm. Other remarkable features: There is a small amount of soft tissue hemorrhage and fat necrosis along the superior lateral edge of the mass. Multiple 0.3 0.4 cm firm nodules are identified radiating from the main mass towards the medial aspect of the breast. These are extensively sampled. Tissue submitted for special investigations: tumor and normal are given to Block Summary:
+
+--- Page 5 ---
+(Inking: anterior=blue, posterior=black and axillary tail=yellow) D1 - nipple, serially sectioned 2 - areola, en face. D3-D4 - intervening section of breast tissue between Mass A and Mass B D5 - Mass A in relationship to closest blue inked superior anterior margin D6 - Mass B in relationship to black inked deep margin D7 - central section of Mass A D8 - small nodule anterior to edge of Mass A D9 - second smaller nodule anterior to medial edge of Mass A D10 - smaller nodule, approximately 2.5 cm medial to edge of Mass A D11 - small nodule, lower inner quadrant. D12 - nodule along inferior edge of specimen. D13 - small nodule approximately 2 cm medial and posterior to edge of Mass A D14 - upper inner quadrant D15 - lower inner quadrant D16 - upper outer quadrant D17 - lower outer quadrant D18 - small nodule, 2.1 cm from edge of Mass A along anterior/superior blue inked edge Container E is additionally labeled "right Level 3 axillary node." It hoids a 4.2 x 2.2 x 0.6 cm unoriented fragment of yellow/tan fibrofatty tissue containing two lymph node candidates up to 1.3 cm in greatest dimension. lock Summary: E1 - one lymph node candidate, bisected. E2 - one lymph node candidate, bisected Fat remains in formalin. Container F is additionally labeled "right axillary node dissection, Levels 1 and 2." It holds an unoriented 12.4 x 5.3 x 2.0 cm aggregate of fat which is dissected for lymph node candidates. Multiple lymph node candidates measuring up to 1.9 cm in greatest dimension are identified. Block summary:e F1 - four lymph node candidates. F2 - four lymph node candidates F3 - three lymph node candidates. F4 - one bisected lymph node candidate F5 - one bisected lymph node candidate F6 - one bisected lymph node candidate F7 - one bisected lymph node candidate 8 - one lymph node candidate, sectioned. 9 - one lymph node candidate (largest), sectioned Light Microscopy:.
+
+--- Page 6 ---
+Light microscopic examination is performed by Dr. Signature Attending Pathologist: I have personally conducted the evaluation of the above specimens and have rendered the above diagnosis(es).
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diff --git a/output/text/ba1ee1a5-425d-4449-86fd-3283dce0cd6e.txt b/output/text/ba1ee1a5-425d-4449-86fd-3283dce0cd6e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..669d2cd29887067b790f71ae57add2a3ddd4d91f
--- /dev/null
+++ b/output/text/ba1ee1a5-425d-4449-86fd-3283dce0cd6e.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+ID-D-3 TCGA-UF-A7JD-01A-PR Redacted 8070h3 Site : Buceal mmucono. c0e.D HtD9/z3/13 Collect date: PATHOLOGY REPORT: PRIMARY SITE: Buccal mucosa 1 - "Neck lymph nodes - Right": - Eighteen lymph nodes with no evidence of metastatic carcinoma (0/18). - Salivary gland fragments with congestion, uninvolved by neoplasia. 2 - Neck lymph nodes": - Two of seven lymph nodes involved by metastatic carcinoma (2/7), with capsular involvement. 3 -- Anterior margin uninvolved by neoplasia 4 - "Retromolar lesion surgical excision specimen': - Poorly differentiated squamous cell carcinoma, ulcerated, measured 4.1 cm, 1.4 cm deep, with necrosis sites. - Lymphovascular invasion: present. - Perineural invasion: present. - Osseous tissue involved by carcinoma. - Intense peritumoral desmoplasia. - Scarce peritumoral lymphocitary infiltrate. - Deep margin involved by carcinoma. - Other surgical margins uninvolved by carcinoma. SOA13
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diff --git a/output/text/ba2d02f0-beb4-436a-b585-7b4f7255df4b.txt b/output/text/ba2d02f0-beb4-436a-b585-7b4f7255df4b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e85fdfe5221f19b981466b8c3e01707e7c5e559d
--- /dev/null
+++ b/output/text/ba2d02f0-beb4-436a-b585-7b4f7255df4b.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+FOR OYFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 UUID:6A97C809-91BB-4E35-9E12-F5F2A58C9D35 TCGA-A2-A04R-01A-PR Redacted PATHOLOGY REPORT Patient: Specimen #: FMP/SSN: DOb/Age/Sex: Age: F Race: BLACK Taken: Location: Received: Physician(s) : Reported: 1cD-0-3 **AMENDED** Carcioma, nifiIrnatsg dluctol,N0s 8.5o0|3 SPECIMEN : A: LEFT SENTINEL LYMPH NODE B: LEFT BREAST TISSUE FINAL DIAGNOSIS: A. LYMPH NODE, LEFT SENTINEL, EXCISION: - NEGATIVE FOR MALIGNANCY BY IMMUNOHISTOCHEMISTRY. B. BREAST, LEFT, LUMPECTOMY: INFILTRATING DUCTAL CARCINOMA, MODERATELY DIFFERENTIATED BY COMBINED HISTOLOGIC CRITERIA. MAXIMUM TUMOR DIMENSION = 2.0 CM. ASSOCIATED DUCTAL CARCINOMA IN SITU, NUCLEAR GRADE 2 WITH NECROSIS. SURGICAL MARGINS ARE NEGATIVE FOR TUMOR MICROCALCIFICATIONS IDENTIFIED IN THE DUCTAL CARCINOMA IN SITU AND THE INFILTRATING CARCINOMA COMPONENTS. ESTROGEN RECEPTOR: POSITIVE (80% nuclear staining) PROGESTERONE RECEPTOR: POSITIVE ( 9O% nuclear staining) (SEE COMMENT). AMMENDMENT 2: FOLLOWING INTRADEPARTMENTAL REVIEW, RESULTS OF HER2 STUDIES ARE REVISED. HER2 BY IMMUNOHISTOCHEMISTRY: WEAKLY POSITIVE (2+) HER2 BY FISH: NOT AMPLIFIED (1.1) COMMENT : Estrogen and progesterone receptors were evaluated by immunohistochemical methods. A positive test is defined as easily discernable nuclear staining in more than 5% of the tumor cells. The specimen was evaluated for HER-2/Neu (c-erbB2) overexpression by immunohistochemical methods (DAko Hercep Test). Staining is interpreted on a scale of 0 to 3+ with positivity defined as 2+ or greater.. Specimens with a weakly positive (2+) Hercep Test are further evaluated by. Page 1 Continued on Next Page OFFICIAL USE ONLY - PERSONAL DATA- PRIVACY ACT OF 1974
+
+--- Page 2 ---
+L USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: FINAL DIAGNOSIS (continued): fluorescence in situ hybridization (Pathvysion Fish assay) to detect. presence or absence of Her-2/neu gene amplification.. ** Report Electronically Signed Out ** CLINICAL DIAGNOSIS AND HISTORY: -year-old female with Tinomo infiltrating ductal carcinoma of left breast on physical exam and core biopsy. GROSS DESCRIPTION: A. LEFT SENTINEL LYMPH NODE received fresh, labeled with the patient's name, designated "LEFT SENTINEL LYMPH NODE" consists of a 2.0~cm x 0.7 cm x 0.4 cm soft, tan tissue fragment. Bisected. 1cF B. LEFT BREAsT TIssuE received fresh, labeled with the patient's name, designated "LEFT BReAsr TIssuE" consists of a piece of fibrofatty tissue, measuring 9.7 cm anterior to posterior, 6.8 cm medial to lateral, and 5.0 cm superior to inferior. The overlying ellipse of brown skin, with a 0.4 cm linear incision, measures 2.6 cm x 0.8 cm. Ink code: Red-lateral, yellow=medial, black-posterior, blue-superior, and green-inferior. The specimen is sectioned anterior to posterior revealing a 2.0 cm tumor, with well-defined margins and white, gritty cut surface, 0.4 cm from the. nearest margin superior. The remaining tissue is mostly fatty with a few patches of white fibrous tissue. One section of skin, one section of. grossly normal fibrous tissue, and two sections of tumor are submitted for the cBcp protocol (matching paraffin section=B1, B2, and B3-B4, respectively). Slide key: Bl: Representative skin. B2: Grossly normal fibrous tissue. B3-B4: Tumor. B5-B6: Anterior margin. B7: Representative fibrous tissue. B8-B9: Tumor. B10-B12: Section of B3. B13-B14: Representative sections. B15-B16: Section of B4. B17: Representative sections. B18-B22: Posterior margin. 22CF Page 2 End of Report FUK UFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
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diff --git a/output/text/ba3e574b-82fc-4b11-8b7e-f1af705b8420.txt b/output/text/ba3e574b-82fc-4b11-8b7e-f1af705b8420.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8069b39f0f9dab690910b2c439ba8fd177a7be52
--- /dev/null
+++ b/output/text/ba3e574b-82fc-4b11-8b7e-f1af705b8420.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Department of Cancer Pathology. Examination: Histopathological examination Material: Multiple organ resection -- segment of the large intestine Unit in charge: TCGA-D5-5541 Material collected on:! Material received on: Clinical diagnosis: Sigmoid colon carcinoma -- sigmoidektomia. Examination performed on:. Macroscopic description: 13.3 cm length of the large intestine with a segment of the mesenterium sized 15 x 10 x 2.5cm.. Cauliflower-shaped tumour sized 5.9 x 4.9 x 1.3 cm in the mucosa. The lesion surrounding 95% of the intestine circumference, located 3.6cm from one of the incision lines, and 6.2 cm from the. opposite one. Microscopic description: Adenocarcinoma tubulopapillare (G2). Infiltratio carcinomatosa telae adiposae pericolicae.. Intestine ends free of neoplastic lesions. Metastases carcinomatosae in lymphonodo (No I / vII).. Histopathological diagnosis:. Adenocarcinoma tubulopapillare coli. Metastases carcinomatosae in lymphonodo (No I / ViII). (G2, Dukes C, Astler-Coller C2, pT3, pN1 ). WRUlORAPIL ARY AREuOCARC(NOMA 0F WHE COiON mEAEFTC WMPH NODE C1/V1l
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diff --git a/output/text/ba6344b7-03cf-4913-aa0b-c0bcfdc7fb59.txt b/output/text/ba6344b7-03cf-4913-aa0b-c0bcfdc7fb59.txt
new file mode 100644
index 0000000000000000000000000000000000000000..55d0845559e09fd0358119b7e0edd7af4c131ea0
--- /dev/null
+++ b/output/text/ba6344b7-03cf-4913-aa0b-c0bcfdc7fb59.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Histopathology UUID: 2330755B-EBE4-46DA-ABAB-A240CD849F36 TCGA-ZF-AA4N-01A-PR Redacted Specimen Comments SPECIMEN Bladder tumour. CLINICAL DETAILS New TCC. Clinically muscle invasive and ? originating from a diverticulum. Incomplete resection. MACROSCOPY 2g of friable tissue chippings + blood clot. MICROSCOPY Sections show a poorly differentiated carcinoma with a solid growth pattern, invading muscularis propria. Laminated layers of keratin, indicating squamous differentiation, are present. Large areas of necrosis are present. No. transitional urothelium has been identified but several strips of non-dysplastic. squamous epithelium are present. No vascular invasion identified.. The features are of a high grade carcinoma but it is not possible to determine. definitively whether this is transitional carcinoma showing squamous differentiation or a primary squamous carcinoma SUMMARY Poorly differentiated carcinoma G3 pT2. Tss Ref: Pathologist could not differenthte Pathologists - ktwuen Shusnous diffurunt`atiun ad tranui#ouI, CosL wiU bi cded eoJ'N0S bd arill bc ennotnted xs Suk. jw n/13/14 1cs~0-3 Ca^cnomx Nos 8010] Site: bIoddv,No5 cl7.9 h119/4 Dual/Sync F
\ No newline at end of file
diff --git a/output/text/ba68544b-3a59-4ecb-b348-57b9d3bd4a77.txt b/output/text/ba68544b-3a59-4ecb-b348-57b9d3bd4a77.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f4b84ef5a9cca860f2141bcdc5a1e92c185c1d03
--- /dev/null
+++ b/output/text/ba68544b-3a59-4ecb-b348-57b9d3bd4a77.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:7FEC6780-415F-42E4-B996-E091CA424621 TCGA-M -A6BN-01A-PR Redacted THIS IS A CONFIDENTIAL AND PRIVILEGED COMMUNICATION PLEASE DISPOSE OF PAPER COPIES APPROPRIATELY Printed by: Name: Age: Test Name: F/S PLEURAL TUMOR{MASS Test Date: Ordered By: COLLECTION DATE: IeD-o.3 SPECIMEN NUMBER: SPECIMENS: 905213 1. F/S PLEURAL TUMOR 2. MASS  5/16/13 DIAGNOSIS: 1. PLEUrA, RIght: BIOPSy  - MALIGNANT EPITHELIOID MESOTHELIOMA. 2. PLEURA: BIOPSY - malignant epithelioid mEsotheliomA. COMMENT: Immunohistochemical study demonstrates the tumor is. positive diffusely for cytokeratin (AE1/AE3) and CK5/6, and focally. positive for calretinin and wT1. The tumor is negative for mCEA,. Ber-EP4 (rare cells +), and TTF1. The findings support the diagnosis. This case has been reviewed intradepartmentally. Pathologist CLINICAL HISTORY AND PRE-OPERATIVE DIAGNOSIS: Lung mass, right MACROSCOPIC DESCRIPTION: The specimen is received in two parts labeled with the patient's name. 1. Part one is received fresh labeled 'pleural tumor'. It consists of three fragments of tan soft tissue that range in size from 0.2 x 0.2 x 0.2 to 1 x 0.4 x 0.2 cm. Entirely submitted for frozen section. 2. Part tow is received fresh labeled with 'pleural tumor'. It consists of one 1.4 x 1.2 x 0.3 cm piece of tan soft tissue. One 0.8 cm tan firm plaque is noted on the surface. The specimen is serially sectioned and entirely submitted. SUMMARY OF SECTIONS 1A in toto 2A in toto
+
+--- Page 2 ---
+SPECIAL PROCEDURES: AE1/AE3, Calretinin, WT1, Ber-EP4, mCEA, CK5/6, TTF1 INTRA - OPERATIVE CONSULTATION: 1. Pleural tumor; frozen section Malignant epithelioid tumor, favor mesothelioma. Results. reported by back by Intra-Operative Consultation #1 performed by. Electronically signed Final Diaanosis performed by Electronically signed The electronic signature attests that the named Attending. Pathologist has evaluated the specimen referred to in the signed section of the report and formulated the diagnosis therein. This report may include one or more immunohistochemical stain results that use analyte specific reagents. The tests were developed and their performance characteristics determined by They have not been cleared or approved by the US Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary.
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diff --git a/output/text/ba68e089-efe5-4814-a492-c19d08d5e302.txt b/output/text/ba68e089-efe5-4814-a492-c19d08d5e302.txt
new file mode 100644
index 0000000000000000000000000000000000000000..826d738c228908e34621612d0d5d1ce94b8ef79f
--- /dev/null
+++ b/output/text/ba68e089-efe5-4814-a492-c19d08d5e302.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+SURGICAL PATHOLOGY REPORT Accession number: Final Report DIAGNOSIS: 1) LARYNX, SUPRAGLOTTIC, BIOPSY: MODERATELY-DIFFERENTIATED SQUAMOUS CELL CARCINOMA. **Electronically Signed Out by CLINICAL DATA Clinical Features:Unspecified. Operator: Dr. Operation: Unspecified Operative Findings: Unspecified Operative Diagnosis: Unspecified Tissue Submitted: 1) Supraglottic lesion GROSS DESCRIPTION: 1) SOURCE: Supraglottic Lesion Received fresh, labeled "supraglottic lesion" are 3 portions of soft, pink, and hemorrhagic mucosa measuring in aggregate 9.0 x 6.0 x 4.0 mm. The specimen is submitted entirely in a teabag following frozen section. Summary of sections: 1AFSC, 3/1. Dictated by Slides and report reviewed by Attending Pathologist.. SURGICAL PATHOLOGY INTRAOPERATIVE CONSULTATION 1) SOURCE: Supraglottic Lesion FROZEN SECTION DIAGNOSIS: SQUAMOUS CELL CARCINOMA. GG/KE Electronically signed by:
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+UUID:83AAF7BF-131D-4044-AD3B-670B838A23D6 TCGA-E2-A56Z-01A-PR Redacted SPECIMEN(S): A. SLN #1 RIGHT AXILLA B. LEFT BREAST TISSUE BIOPSY WITH NEEDLE LOCALIZATION C. RIGHT BREAST TISSUE BIOPSY WITH NEEDLE LOCALIZATION D. ADDITIONAL MEDIAL SUPERIOR MARGIN RIGHT BREAST E. RIGHT AXILLARY CONTENTS Icd-0-3 CLINICAL HISTORY: Cmnma,mfitahNy duct, nvs 85oof3 None Given Site? brust, Nos C50.9 M PRE-OPERATIVE DIAGNOSIS: 213/1> Right breast cancer- left breast atypia. INTRAOPERATIVE CONSULTATION: TPA: SLN #1 right axilla- Positive for carcinoma. Diagnosis called to Dr. at by Dr. DIAGNOSIS: A. LYMPH NODE, SENTINEL #1, RIGHT AXILLA, EXCISION: - METASTATIC CARCINOMA TO ONE OF ONE LYMPH NODE (1/1), MEASURING 0.3-CM WITH NO EXTRANODAL EXTENSION. B. BREAST, LEFT, WIDE LOCAL EXCISION: - FOCAL FIBROADENOMATOID CHANGES WITH COARSE CALCIFICATIONS - BIOPSY SITE CHANGES WITH FIBROSIS, GRANULATION TISSUE FOREIGN BODY GIANT CELL REACTION AND FAT NECROSIS, NO TUMOR SEEN. C. BREAST, RIGHT, WIDE LOCAL EXCISION: - INVASIVE DUCTAL CARCINOMA WITH PAPILLARY AND FOCAL MUCINOUS FEATURES, SBR GRADE 2, MEASURING 3-CM - HIGH NUCLEAR GRADE, DUCTAL CARCINOMA IN SITU, SOLID, MICROPAPILLARY. PAPILLARY AND CRIBRIFORM TYPES WITH CENTRAL NECROSIS AND MICROCALCIFICATIONS - SURGICAL RESECTION MARGINS NEGATIVE FOR TUMOR - BIOPSY SITE CHANGES WITH FIBROSIS, GRANULATION TISSUE, FOREIGN BODY GIANT CELL REACTION AND FAT NECROSIS - SEE SYNOPTIC REPORT AND SEE NOTE D. BREAST, RIGHT, ADDITIONAL MEDIAL SUPERIOR MARGIN, EXCISION: - BREAST TISSUE NO TUMOR SEEN. E. LYMPH NODES, RIGHT, AXILLARY DISSECTION:
+
+--- Page 2 ---
+- FIFTEEN LYMPH NODES, NEGATIVE FOR METASTASES (O/15). NOTE: Invasive ductal carcinoma is identified in 5 consecutive slices from lateral to medial, measuring about 3.0 CM. HER-2/neu test by FISH is ordered, since the core needle biopsy results were equivocal. SUMMARY OF IMMUNOHISTOCHEMISTRY/SPECIAL STAINS Material: Block A1 Population: Lymph Node Stain/Marker:  Result: Comment:  CYTOKERATIN AE1/3  Positive CYTOKERATIN 7 Negative  S-100  Negative ESTROGEN RECEPTOR  Positive Material: Block C7 Population: Tumor Cells Stain/Marker: Result: Comment:  CYTOKERATIN AE1/3  Positive  CYTOKERATIN 7  Negative  S-100  Negative  ESTROGEN RECEPTOR  Positive Material: Block C12 Population: Tumor Cells  Stain/Marker: Result: Comment: P63  Negative  CALP  Negative SMOOTH MUSCLE  Negative  MYOSIN The interpretation of the above immunohistochemistry stain or stains is guided by published results in the medical literature, provided package information from the manufacturer and by internal review of staining performance and assay validation within the Immunohistochemistry Laboratory of the The use of one or more reagents in the above tests is regulated as an analyte specitic reagent (ASR). These tests were developed and their performance characteristic determined by the Department of Pathology Laboratory al 'hey have not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. Special stains and/or immunohistochemical stains were performed with appropriately stained positive and/or negative controls.
+
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+SYNOPTIC REPORT - BREAST Specimens Involved Specimens: A: SLN #1 RIGHT AXILLA C: RIGHT BREAST TISSUE BIOPSY WITH NEEDLE LOCALIZATION D: ADDITIONAL MEDIAL SUPERIOR MARGIN RIGHT BREAST E: RIGHT AXILLARY CONTENTS Specimen Type: Excision Needle Localization:. Yes Laterality: Right Invasive Tumor: Present Multifocality: No WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Tumor size: 3cm Margins: Negative Distance from closest margin: 0.4cm anterior Tubular Score: 2 Nuclear Grade: Mitotic Score: 3 Modified Scarff Bloom Richardson Grade: 2 Necrosis: Absent Vascular/Lymphatic Invasion: None identified Lobular neoplasia:  None Lymph nodes: Sentinel lymph node. Axillary dissection Lymph node status: Positive 1/ 16 Micrometastases: No DCIS present Margins uninvolved by DCIS DCIS Quantity: Estimate 10% DCIS Type: Cribriform  Micropapillary  Papillary DCIS Location: Associated with invasive tumor Nuclear grade: High Necrosis:  Present Location of CA++: DCIS ER/PR/HER2 Results ER: Positive PR: Positive HER2: Pending by FISH Performed on Case: ER/PR on case. HER2 by FISH pending on the current case Pathological staging (pTN): pT 2 N la Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition
+
+--- Page 4 ---
+GROSS DESCRIPTION: A. SLN #1 RIGHT AXILLA Received fresh labeled with the patient's identification and 'SLN #1 right axilla' is a tan pink lymph node 1.7 x 0.9 x 0.7cm. The specimen is serially sectioned. A touch prep is taken. Toto A1. B. LEFT BREAST TISSUE BIOPSY WITH NEEDLE LOCALIZATION Received in formalin labeled with the patient's identification and 'left breast tissue biopsy with needle localization' are two oriented, previously inked lumpectomy specimens 59g and 53g each -- when placed back together by the surgeon, measuring 11.5 x 8 x 4.5cm. Ink code- anterior-yellow, posterior-black, superior-blue, inferior-orange, medial-green, lateral-red. Specimen is serially sectioned in to 15 slices revealing a 0.6 x 0.5 x 0.5cm previous biopsy site with surrounding necrosis, at the anterior margin in. slices 4-5-6. The specimen is radiographed and areas of concern are marked by the radiologist. A biopsy clip is identified in slice 5. Representatively submitted: B1-B2: medial margin slice 1 B3: anterior margin slice 2 B4: anterior margin slice 3 B5: bx site with anterior margin slice 4. B6: inferior margin slice 4 B7: bx site with anterior margin and clip ID slice 5 B8: superior margin slice 5 B9: posterior margin slice 5 B10: inferior margin slice 5 B11: bx site with anterior margin slice 6 B12: superior-posterior margin marked by the radiologist slice 14 B13-B14: inferior margin slice 14 B15: lateral margin marked by the radiologist slice 15 C. RIGHT BREAST TISSUE BIOPSY WITH NEEDLE LOCALIZATION Received in formalin labeled with the patient's identification and 'right breast tissue biopsy with needle localization' is an oriented, previously inked 201g, 15.2 x 11 x 3.4cm needle localized lumpectomy with two radiographs. Ink code- anterior-yellow, posterior- black, superior-blue, inferior-orange, medial-green, lateral-red. Specimen is serially sectioned in to 11 slices revealing a tan white gelatinous lobulated mass 5.3 x 4 x 2.8cm, 0.1cm from the closest anterior and posterior margins in slices 2-3-4-5-6-7 and 8. A. portion of the specimen is submitted for tissue procurement. Representatively submitted: C1: lateral margin slice 1 C2: mass with anterior margin slice 2 C3: mass with anterior margin slice 3 C4-C5: mass with anterior margin slice 4 C6-C8: mass with anterior margin slice 5 C9: superior margin slice 5 C10-C11: mass with posterior margin slice 6 C12: mass with posterior margin slice 7 C13: anterior -- inferior margins slice 7. C14: mass slice 8 C15: inferior margin slice 9
+
+--- Page 5 ---
+C16: posterior margin slice 10 C17: medial margin slice 11 D. ADDITIONAL MEDIAL SUPERIOR MARGIN RIGHT BREAST Received in formalin labeled with the patient's identification and 'additional medial superior margin right breast' is an oriented 37g, 7 x 7 x 3cm fibrofatty tissue. Final. margin inked blue. Serial sectioning reveals unremarkable parenchyma. Representatively. submitted in D1-D6. E. RIGHT AXILLARY CONTENTS Received in formalin labeled with the patient's identification and 'right axillary contents are multiple tan pink fragments of fibrofatty tissue aggregating to 15 x 8 x 3.5cm.. Dissection reveals sixteen lymph nodes ranging from 3.5 x 2.4 x 1.6cm to 0.2 x 0.2 x 0.2cm. E1: five lymph nodes E2: five lymph nodes E3: two lymph nodes E4: one lymph node E5-E6: one lymph node E7-E8: one lymph node E9-E10: one lymph node
+
+--- Page 6 ---
+ADDENDUM: FISH/ISH ANALYSIS REPORT 3 Specimens Involved Specimens: C: RIGHT BREAST TISSUE BIOPSY WITH NEEDLE LOCALIZATION HER2/NEU RESULTS ANALYTICAL INTERPRETATION OF RESULTS HER-2 NOT AMPLIFIED Clinical interpretation of the results A majority of tumors cells displayed moderate polysomy 17 with 2 to 3 chromosome 17 centromere signals and 2 to 4 HER2 signals, with a HER2/CEP 17 Ratio 1.5, consistent with no amplification of the HER2/neu gene. Probes identification LSI Her-2/neu 17q11.2-12, spectrumorange CEP 17, 17 p11.1-q11.1 alpha satellite DNA, spectrumgreen Image analysis method - Manual Results interpreted Yes ISCN nuc ish: (CEP17x2),(HER2x3)[200] Number of invasive tumor cells counted 200 Number of observers 1 Number of Her2 signals/nucleus 3.2 Number of CEP 17 signals/nucleus 2.2 Her2/CEP 17 ratio 1.5 TEST CHARACTERISTICS: HER-2 DNA Probe Kit is FDA approved for selection of patients for whom Herceptin therapy is being considered. These tests were performed in the Pathology Core Facility, Department of Pathology, : under the direction of Dr.. The results of these studies should always be interpreted in the context of the clinical, morphological, and immunophenotypic diagnosis. The Kit is not intended for use to screen for or diagnose breast cancer. It is intended to be used as an adjunct to other prognostic factors currently used to predict disease-free and overall survival in stage II, node-positive breast cancer patients. In making decisions regarding adjuvant CAF treatment, all other available clinical information should also be taken into consideration, such as tumor size, number of involved Iymph nodes, and steroid receptor status. No treatment decision for stage II, node-positive breast cancer patients should be based on HER-2/neu gene amplification status alone. Specimen information RPCI surgical pathology/cytology case number Source of case RPCI Block number used C7 Specimen site Breast
+
+--- Page 7 ---
+Female breast right Specimen type Complete excision (less total mastectomy) Specimen fixative type Formalin Duration of fixation (hrs)  6 - 48 hrs Comment: Controls: The FISH study was performed with appropriately stained positive and negative controls.
+
+--- Page 8 ---
+ADDENDUM: ONCOTYPE DX BREAST CANCER ASSAY REsULTS: Recurrence Score:27 CLINICAL EXPERIENCE: Patients with a recurrence score of:  27 in the clinical validation study had an average rate of Distant Recurrence at 10 years of 18% ER Score: 12 Positive PR Score: 6.7 Positive Her2 Score: 9.1Negative Interpretation: ER Negative<6.5 Positive>= 6.5 PR Negative<5.5 Positive>=5.5 Her2 Negative <10.7 Positive >=11.5 Equivocal = 10.7 - 11.4 See separate report for further information..
+
+--- Page 9 ---
+L hiops1 1ep4 left breast bx SPECIMENS: A. LEFT BREAST CENTRAL CORE BIOPSY B. RIGHT BREAST SUBAREOLAR CORE BIOPSY SPECIMEN(S): A. LEFT BREAST CENTRAL CORE BIOPSY B. RIGHT BREAST SUBAREOLAR CORE BIOPSY DIAGNOSIS: A. BREAST, LEFT, CENTRAL, BIOPSY: - MINUTE FRAGMENTS OF ATYPICAL CELLS WITH NECROSIS - STROMAL CALCIFICATIONS, SEE NOTE. NOTE: Scattered minute fragments of crushed cells with necrosis are identified. They may represent. contents of DCiS. Multiple levels are examined. Excisional biopsy is recommended. B. BREAST, RIGHT, SUBAREOLAR, BIOPSY: - INVASIVE DUCTAL CARCINOMA, SBR GRADE 2, SEE NOTE NOTE: Maximum invasive tumor size measures 0.8-cm. This measurement may not reflect the actual size of the tumor. Breast biomarkers are ordered. GROSS DESCRIPTION: A. LEFT BREAST CENTRAL CORE BIOPSY Received in formalin labeled with the patient's identification and 'left breast central core biopsy' are multiple tan vellow cores of tissue ranging from 4.3 x 0.2cm to 0.5 x 0.2cm. Toto A1-A2. Time placed in formalin- B. RIGHT BREAST SUBAREOLAR CORE BIOPSY Received in formalin labeled with the patient's identification and 'right breast subareolar core biopsy' are. four tan yellow cores of tissue ranging from 1.1 x 0.1cm to 0.5 x 0.1cm. Toto B1. Time placed in formalin- CLINICAL HISTORY: A) Suspicious calcification in central left breast. B) New mass - highly suspicious for cancer. PRE-OPERATIVE DIAGNOSIS: A) Rule out DCIS ADDENDUM: SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimen: Breast Core Needle Biopsy Block Number: ER: Positive Allred Score: 8 = Proportion Score 5 + Intensity Score 3 PR: Positive Allred Score:  5 = Proportion Score 2 + Intensity Score 3 COMMENT: The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring. range from O to 8. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score. of less than or equal to 2.
+
+--- Page 10 ---
+METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Immunohistochemistry was performed using the mouse anti-human ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) provided by 'ollowing the manufacturer s instructions. This assay was not modified. interpretation of the ER/PR immunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal. review of staining performance. SYNOPTIC REPORT - BREAST HER-2 RESULTS Specimen: Breast Core Needle Biopsy Block Number: Interpretation: EQUIVOCAL Intensity: 2+ % Tumor Staining: 10% Fish Ordered: Yes METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Her2 analysis was performed using the FDA approved HercepTest (TM) test kit . 'ssing rabbit anti-human HER2. This assay was not modified. External kit-slides provided by the manufacturer (cell lines with high, low and negative HER2 protein expression) and in- house known HER2 amplified control tissue were evaluated along with the test tissue. Adequate, well preserved, clear-cut invasive carcinoma was identified for HER2 evaluation. Interpretation of the HER2 immunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal review of staining performance. This assay has been validated according to the joint recommendations and guidelines from ASCO and CAP and from the NCCN HER2 testing in Breast Cancer Task Force. The 7athology Department takes full responsibility for this test's performance. FISH/ISH ANALYSIS REPORT 3 Specimens Involved SpecimenS: B: RIGHT BREAST SUBAREOLAR CORE BIOPSY HER2/NEU RESULTS ANALYTICAL INTERPRETATION OF RESULTS INDETERMINATE (EQUIVOCAL) FOR HER-2 AMPLIFICATION Clinical interpretation of the results A majority of tumors cells displayed 2 to CEP17 signals and 4 to 5 HER-2 signals, with a HER-2/CEP 17 Ratio of 2. A HER-2/CEP 17 Ratio of >2.2 is generally considered amplification, while a ratio of 1.8 to <2.2 is generally considered indeterminate. This specimen is a biopsy and recommendation is to repeat HER2 FISH test on resection specimen. Probes identification. .SI Her-2/neu 17q11.2-12, spectrumorange CEP 17, 17 p11.1-q11.1 alpha satellite DNA, spectrumgreen Image analysis method - Manual Results interpreted Yes  Number of invasive tumor cells counted 100 Number of observers. Number of Her2 signals/nucleus 4.0  Number of CEP 17 signals/nucleus 2.0 Her2/CEP 17 ratio 2.0 TEST CHARACTERISTICS: PathVysion HER-2 DNA Probe Kit is FDA approved for selection of  patients for whom Herceptin therapy is being considered. These tests were performed in the Pathology
+
+--- Page 11 ---
+Core Facility, Department of Pathology, . under the direction of Dr.. The. results of these studies should always be interpreted in the context of the clinical, morphological, and immunophenotypic diagnosis. The PathVysion Kit is not intended for use to screen for or diagnose breast cancer. It is intended. to be used as an adjunct to other prognostic factors currently used to predict disease-free and overall survival in stage Il, node-positive breast cancer patients. In making decisions regarding adjuvant CAF treatment, all other available clinical information should also be taken into consideration, such as tumor. size, number of involved lymph nodes, and steroid receptor status. No treatment decision for stage II, node-positive breast cancer patients should be based on HER-2/neu gene amplification status alone. Specimen information Block number used Comment: Controls: The FiSH study was performed with appropriately stained positive and negative controls.
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+Ics.0. mifilmating ouctal, Nos 85c0f3 Carcii omn, CQF: brsst, Nos 'Cso.9 Jas/n urgica! Pathoiogy: Add Surg Path UUID:F05F5886-DC5D-4685-B20F-57A68A0BB789 TCGA-B6-A0WW-01A-PR Redacted CLINICAL HISTORY: Cervical cancer and breast cancer. GROSS EXAMINATION: A. "True cut breast biopsy", AFl. Frozen tissue remnant labeled AFl submitted in toto in block Al.. B. "Cervical tumor", tissue fragment labeled BFl in submitted in toto in block. B1. A 4.2 x 3 x 2.3 cm aggregate of tan tissue containing multiple edematous. papillary structures. Representative sections are submitted in blocks B2 and B3. A representative sample of the specimen is placed in a tea bag for gross photography. C. "Right breast and axillary nodes", received unfixed and placed in formalin. A sample of fresh tissue has been sent for ER/pR. A 580 gm,. 28.4 x 15.3 x 3.9 cm modified radical mastectomy specimen containing a 22.0 x. 15.3 x 3.9 cm breast with an 8.5 x 5.8 x 2 cm axillary tail, and a 2 cm nipple white hard mass located within the upper inner portion of the breast l.1 cm from the inked deep margin and 1.7' cm from'the skin surface. tail contains multiple firm matted lymph nodes within the proximal mid and. The axillary distal portions, the largest measuring 3.5 x 1.4 x 1 cm. contains a soft pale pink 5 x 1.2 x 1.5 cm. The breast also dissected for lymph nodes..  The axillary tail is removed and BLOCK SUMMARY: C1-c2 - tumor with soft tissue margins. c3-c4 - random soft tissue margins C5-c7 - tumor c8-c9 - unremarkable breast tissue c10-C11 - - representative sections of skin c12 - section of areola C13 section of nipple C14 - one bisected lymph node candidate from the proximal axillary lymph. nodes c15 - three lymph node candidates from the proximal axillary lymph nodes. C16 - six lymph node candidates from the mid axillary lymph nodes c17 - one bisected lymph node candidate from mid axillary lymph nodes. c18 - two lymph node candidates from the distal axillary lymph nodes c19 - one bisected lymph node candidate from the distal portion of axillary lymph nodes Dr. /Dr. 'slides to Dr. INTRA OPERATIVE CONSULTATION:S A. "True cut breast", AFl: invasive carcinoma (Dr. B. "Cervical tumor", BFl: papillary squamous cell carcinoma in situ at least (Dr. DIAGNOSIS : A. "TRUE CUT BIOPSY": INFILTRATING DUCTAL [CARCINOMA. N.S.A.B.P. NUCLEAR GRADE 2 OF 3. N.S.A.B.P. HISTOLOGIC GRADE 3 OF 3. LYMPHATIC/VASCULAR INVASION PRESENT. Revi https:/
+
+--- Page 2 ---
+"CERVICAL TUMOR": B. POLYPOID PAPILLARY SQUAMOUS CELL CARCINOMA IN-SITU WITH EQUIVOCAL EARLY STROMAL INVASION. (SEE COMMENT). "RIGHT BREAST AND AXILLARY NODES" (MODIFIED RADICAL MASTECTOMY): RESIDUAL INFILTRATING DUCTAL CARCINOMA.S N.S.A.B.P. NUCLEAR GRADE 2 OF 3. N.S.A.B.P. HISTOLOGIC GRADE 3 OF 3. GROSS TUMOR SIZE 4.1 X 2.6 X 4.0 CM (GROSSLY). SIZE OF INVASIVE COMPONENT 4.1 CM. LOCATION OF THE TUMOR, UPPER INNER QUADRANT.S LYMPHATIC/VASCULAR INVASION PRESENT.S MULTIFOCAL TUMOR NO. IN SITU CARCINOMA PRESENT, OCCUPYING APPROXIMATELY 5% OF TUMOR. TYPE OF IN-SITU CARCINOMA CRIBRIFORM WITH NECROSIS AND SOLID TYPES (SLIDES C4, C6, C7) EXTENSIVE INTRADUCTAL COMPONENT, NO. NIPPLE STATUS, FREE OF TUMOR. SKIN STATUS, FREE OF TUMOR. MUSCLE STATUS, NOT SAMPLED. STATUS OF NON-NEOPLASTIC BREAST TISSUE: FIBROSIS. SURGICAL MARGIN STATUS: NEGATIVE. LYMPH NODE STATUS: METASTATIC CARCINOMA IN EIGHT OF 15 RIGHT AXILLARY LYMPH NODES. SIZE OF LARGEST LYMPH NODE METASTASIS 1.5 CM (SLIDE C14). EXTRANODAL INVASION PRESENT (SLIDE C14).S ESTROGEN/PROGESTERONE RECEPTOR AND CELL CYCLE ANALYSIS PENDING. METHODOLOGY: IMMUNOHISTOCHEMISTRY, PARAFFIN BLOCK (C6). cOMMEnr: The lesion displays in-situ form of cancer that architecturally resembles the papillary transitional cell cancer, grade 1, commonly seen in. the bladder. In multiple areas, the base of the epithelium is cut on a bais, so that it cannot be determined whether the few cells seen in the superficial stroma are artifactual or the earliest form of microinvasion. While such a lesion, if seen in the bladder, would be called low grade, there is no recorded experience with such a neoplasm in the cervix. Dr. has reviewed the slides of the cervical tumor and concurs with the diagnosis. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es). , M.D. Page# Electronically signed: ADDENDUM 2: Breast tissue was sent to the - estrogen and progesterone receptors. The estrogen receptor activity was , for assay of the. judged to be positIvE with an estimated FMoL value of 99. The progesterone receptor activity was judged as posiTive with an estimated rMoL value of 15. Please refer to for a complete report. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es). http
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+MRN: NoRmAsqqnd Age: Sex: F DOB: Surgical Pathology Histopathological Examination Path# Collected: Received: Supplement :. Pre-Op Diagnosis Cecal  Mass Order Physician. Specimens Colon Segment, Terminal ileum and right colon Frozen Diagnosis : Report : SUPPLEMENTAL REPORT, This supplemental report is issued to report FIsh results Fish analysis is negative for the t(ll;l4) translocation. This finding, in conjunction with the negative immunohistochemical stain for cyclin Dl, excludes mantle cell lymphoma. The FIsh study does show another IGH rearrangement involving an unknown partner chromosome. IGH rearrangements are commonly seen in diffuse large B-cell lymphoma. The final diagnosis is thus amended as follows: Terminal ileum and right colon, resection: - CD5-positive diffuse large B-cell lymphoma. - Five lymph nodes, no tumor present (0/5).. Intradepartmental consultation obtained. This case was discussed with GROSS EXAMINATION: The specimen is received in formalin in a container labeled with the name of the patient and identified as colon segment, terminal ileum and right colon.. Circumference of Terminal Ileum: Up to 1l cm. Length of Colon: 12 cm Circumference of Colon: Up to 7.5 cm Margins: Stapled closed THIS CONFIDENTIAL AND PRIVILEGED DOCUMENT/INFORMATION IS PROTECTED BY FEDERAL AND STATE LAW. UNAUTHORIZED DISCLOSURE, DISSEMINATION OR DUPLICATION IS PROHIBITED Path #: Page 1 of 2 Visit # :
+
+--- Page 2 ---
+Serosa: Scattered fibrous adhesions Mass: Size: 11.5 x 7 x 2.5 cm Type: Ulcerated and infiltrative. Reqion:. Terminal ileum, ileocecal valve, and cecum Distance from Margin: 7 cm, proximal; 8 cm, distal. Circumference: 100% Depth of Invasion: Grossly extends through the wall Distance from Radial Margin: Approximately 1.5 cm Appendix: No Block Summary: Proximal margin l, distal margin 2, radial margin 3, mass 4-1l, uninvolved small bowel i2, uninvolved colon 13, four potential lymph nodes 14. A portion of the mass is submitted for flow studies. Case reviewed with DIAGNOSIS BASED ON GROSS AND MICROSCOPIC EXAMINATION: Terminal ileum and right colon, resection: - B-cell lymphoma involving full thickness of terminal ileum, ileocecal valve, and cecum (see comment). Five lymph nodes, no tumor present (0/5). COMMENT : Sections of the mass show a diffuse infiltrate of medium sized atypical lymphocytes extending from the mucosa to the subserosal adipose tissue. Flow cytometry showed a monoclonal B-cell population positive for cDl9, CD5, bright cD20, Fmc-7, and lambda. As the flow cytometry results were inconclusive, suitable immunohistochemical stains were evaluated to further characterize this lymphoma. Immunohistochemical stains show the tumor cells to be positive for BCL-6, CD23, CD5, and PAX5. Cyclin Dl, MUM-l, CD10, CD3, and cD43 are negative.  A MIB-1 proliferative index is approximately 50%. This is a challenging case. The immunoprofile is of a B-cell lymphoma.  The differential diagnosis is between a cD5 positive diffuse large B-cell lymphoma versus an atypical mantle cell lymphoma. Tissue has been sent for FIsh studies for the t(ll;l4) translocation to help clarify the diagnosis. Results of Fish studies will be reported in an addendum when available. Intradepartmental consultation obtained. Results communicated to. Electronically Signed by:. THIS CONFIDENTIAL AND PRIVILEGED DOCUMENT/INFORMATION IS PROTECTED BY FEDERAL AND STATE LAW.  UNAUTHORIZED DISCLOSURE, DISSEMINATION OR DUPLICATION IS PROHIBITED Path #: Page 2 of 2 Visit #:
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+--- Page 1 ---
+UUID: 2E0238CF-4E3F-4838-A7EC-804E367E6472 CGA-A4-A5DU-01A-PR Redacted Patient: Referring Physician: Gender:F Ret#: Hosp#: Provider Group : Date of Service: Date Received: Case #: FINAL SURGICAL PATHOLOGy REPORT Diagnosis: A. Left renal mass, ParTIal NephreCtOmy: - PAPILLARY RENAL CELL CARCINOMA (TYPE 1), FUHRMAN NUCLEAR GrADE 2. - TUMOR IS CONFINED TO KIDNEY AND MEASURES 2.2 CM IN GREATEST DIMENSION. - TUMOR FOCALLY INVOLVES CAUTERIZED PARENCHYMAL RESECTION MARGIN. - NO LYMPHOVASCULAR INVASION IDENTIFIED. - ADJACENT BENIGN RENAL PARENCHYMA PRESENT. B. BASE Of LEFT RENAL MASS, BIOPSY: - MINUTE FRAGMENT OF CAUTERIZED BENIGN RENAL PARENCHYMA. - NEGATIVE FOR MALIGNANCY. PATHOLOGIC TUMOR STAGING SYNOPSIS: Type and grade (invasive): Papillary renal cell carcinoma, Fuhrman  nuclear grade 2. Primary tumor: pT1a. IcD6-3 Regional Iymph nodes: pNX. arcinomc papi)(av Distant metastasis: N/A. renal Cel1 826B Stage: I. Lymphovascular invasion: Not identified Site: O Kidny N6S Margin status: R1, focally positive.. Cb4.9 AU1z/24/1Z Kidney Tumor Staging Information. Data derived from current specimen. Staging in accordance witn or moditied from AJCC Cancer Staging Handbook, 7th Ed, and CAP protocol, Case #. Page 1 This report continues... (FINAL) Acct No. Patient Name - athology - Page 1/3 age 1 Doc# 1
+
+--- Page 2 ---
+Patient: Case # Procedure: Partial nephrectomy. Laterality: Left kidney. TUMOR FEATURES Tumor size 2.2 cm in greatest dimension. Tumor focality Unifocal. Extent of tumor: Tumor confined to kidney. Histologic type: Papillary renal cell carcinoma (type 1). Sarcomatoid features: Not identified. Histologic grade: Fuhrman nuclear grade 2 Microscopic turnor extension: Tumor confined to kidney. MARGINS: Parenchymal resection margin: Focally positive. LYMPH NODES: N/A. PATHOLOGIC STAGING: Primary tumor: pT1. Regional lymph nodes: N/A. Distant metastasis: N/A. Stage: 1. Patholagic findings in non-neoplastic kidney: None. Source of Specimen: Case # Page 2. This report continues... (FINAL.) Acct No. . Patient Name - 'athology - Page 2/3 Page 2 Ooc# 1
+
+--- Page 3 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT A. Kidney,Left renal mass B. Base of left renal mass Clinical Historv/Operative Dx:. Left renal mass Gross Description: A. Single specimen designated left renal mass -. Initially received in a fresh state for Oncogenotyping studies, is an ovoid and tobular portion of red-tan, soft tissue, 3.2 x 2.2 x 2.2 cm and 5 grams. The likely surgical margin is marked blue. The superficial surface is glistening with light pink-yellow changes, now marked orange. Sectioning demonstrates a well circumscribed, softened, partially degenerated, yellow-tan tumor mass, measuring 2.2 x 2.0 x 1.8 cm. The tumor mass abuts the deep surgical margin, and overlying renal capsule. The tumor partially abuts or approaches within 0.3 cm of the peripneral surgical margins. The specimen is entirely submitted for microscopic evaluation, in a. sequential fashion in A1-A6.. B. Part B designated base of left renal mass. Received in formalin is a single discrete fragment of partially cauterized light pink and gray soft tissue measuring 0.6 x 0.4 x 0.1 cm. The fragment is submitted within a filter bag in 81. Microscopic Description:. A. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered. B. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered. Intradepartmental consuttation: nas reviewed a representative slide of tumor and concurs. with the presence of a positive margin. Case # Page 3 END OF REPORT (FINAL) MR No. - Acct No. - Patient Name - 'athology - Page 3/3 Page 3 Doc# 1
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index 0000000000000000000000000000000000000000..f826b8d76effbb969c2e3c1070cfe687468ffb8b
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+
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+ichat/ UUID:4CD6BDB7-9629-41C6-8514-7661E3D33A66 TCGA-A1-A0SI-01A-PR Redacted /cs-0-3 carciomn, nifiHhrating duct, Nvs 850cf3 Site: breast, Nos. c50.9 Final Pathologic Diagnosis: A. Sentinel lymph node #1, right axilla, biopsy: No tumor identified in one lymph. node (0/1). B. Non-sentinel lymph node #2, right axilla, biopsy: One lymph node positive for metastatic carcinoma (1/1). C. Sentinel lymph node #2, right axilla, biopsy: No tumor identified in one lymph node (0/1). D. Non-sentinel lymph node #1, right axilla, dissection: No tumor identified in one. lymph node (0/1).. E. Non-sentinel lymph node #3, right axilla, dissection: Fibrofatty tissue, no tumor or lymph node tissue seen on level sections. Poge I ot'S
+
+--- Page 2 ---
+Surgicai Pathology - Working Draft F. Right breast, lumpectomy: 1. Invasive ductal carcinoma, SBR grade II, 2.6 cm; see comment. 2. Lymphovascular invasion present. 3. Usual ductal hyperplasia. G. Lymph nodes, right axillary contents, dissection: No tumor identified in nineteen. lymph nodes (0/19). Note: Breast Tumor Synoptic Comment - Laterality: Right. - Invasive tumor type: Invasive ductal carcinoma NOs. - Invasive tumor size: 2.6 cm maximum diameter (tumor spans slices 2-8, best seen in slides F4, F6,. F8, F10, F12, F13, and F15). - Invasive tumor grade (modified Bloom-Richardson): II. Nuclear grade: 2, 2 points. Mitotic count: 3 mitotic figures/10 HPF, 1 point.. Tubuie/papilla formation: Definite tubule formation in less than 10%, 3 points. Total points and overall grade = 6 points = grade 2. - Lymphatic-vascular invasion: Present (slide F15).. - Resection margins for invasive tumor: - Deep margin: Negative; tumor is within less than 0.1 cm on slide F6 (biack ink). - Medial margin: Negative. - Lateral margin: Negative. - Anterior/superior margin: Negative; tumor is within less than 0.1 cm on slide F10 (blue ink) - Anterior/inferior margin: Negative; tumor is within 1 cm on slide F8 (green Ink).. - Ductal carcinoma in situ (Dcis) type: None identified. - Lobular carcinoma in situ (Lcis): None Identified. - Lymph node status:. - Number of positive lymph nodes: 1. - Total number sampled: 23. - Diameter of largest metastasis: 3 mm.. - Extranodal extension: Absent. - AJCc/uiCC stage: pT2n1mX. - Nontumorous breast tissue: Usual ductal hyperplasia. - Nipple: Unremarkable. - Skin/dermis: Unremarkable. - Additional comments: ER, PR, and HER-2/neu stains have been ordered and will be reported in an addendum. Intraoperative Consult Diagnosis FS1 (A) Sentinei lymph node #1, right axilla, biopsy: One lymph node with no evidence of metastatic. carcinoma. (Dr. FS2 (B) Non-sentinel lymph node #2, right axilla, biopsy: Metastatic carcinoma. (Dr.. FS3 (C) Sentinel lymph node #2, right axilla, biopsy: One lymph node with no evidence of metastatic. carcinoma. (Dr. :) Clinical History The patient is a year-old woman who undergoes a right breast lumpectomy with axillary lymph node dissection. Gross Description The specimen is received in seven parts, each labeled with the patient's name and unit number.. Page 2 of 8
+
+--- Page 3 ---
+Surgical Pathology -. Working Draft consists of a single soft, irregular, red-tan Part A, labeled candidate lymph node measuring 1.2 x 0.6 x 0.4 cm. The entire specimen is frozen for frozen section diagnosis 1, and subsequently submitted in cassette A1. Part B, labeled "non-sentinel lymph node #2 right axilla," consists of a single soft, irregular, red-tan candidate lymph node measuring 1.3 x 0.8 x 0.5 cm. The entire specimen is frozen for frozen section diagnosis 2, and subsequently submitted in cassette B1. consists of a single soft,. Part C, labeled irregular piece of red-yellow, fatty tissue measuring 1.5 x 1 x 0.4 cm. Fatty tissue is trimmed away, and a single candidate lymph node is found. The candidate lymph node is entirely submitted for frozen section diagnosis 3, and subsequently submitted in cassette C1. The remaining unused fatty tissue is entirely submitted in cassette C2. consists of one soft and firm, Part D, received in formalin and Iabeled tan-yellow, fatty tissue fragment measuring 1.7 x  x 0.4 cm. The entire specimen is submitted in cassette D1. consists of one soft and firm, Part E, received in formalin and labeled tan-yellow, fatty tissue fragment measuring 1.6 x 1.2 x 0.4 cm. The entire specimen is submitted in cassette E1. It consists of a 9-gm. Part F is received in formalin and additionally labeled breast lumpectomy specimen, measuring 1.5 cm from anterior to posterior, 5 cm from superior to inferior, and 3.5 cm from lateral to medial. There is a short stitch designated as superior and a long stitch designated as lateral. The specimen is Inked as follows: anterior superior blue, anterior inferior the posterior portion of the green, and posterior black. Prior to receipt by me (Dr. breast has been incised and tissue removed for tissue banking. The specimen is serially sectioned, from medial to lateral, into eight slices and reveals a well-circumscribed, tan, firm nodule (1.5 x 1 x 0.9 cm) in slices 3 through 6. The tumor nodule is located approximately 1 cm from both the latera!- and medial-most margins, 0.7 cm from the superior margin, and 1.3 cm from the inferlor margin. The closest approach to a margin is in slice 6, where it appears to abut the anterior-mid portion of the specimen (<1 mm grossly from the blue/green-inked margin). The specimen is entireiy submitted as follows: Cassette F1: Medial-most margin.. Cassette F2: Slice 2, superior. Cassette F3: Slice 2, inferior. Cassette F4: Slice 3, superior (and nodule). Cassette F5: Slice 3, inferior. Cassette F6: Slice 4, superior (and nodute). Cassette F7: Slice 4, inferior. Cassette F8: Slice 5, superior (and nodule). Cassette F9: Slice 5, inferior. Cassette F10: Slice 6, superior (and nodule). Cassette F11: Slice 6, inferlor. Cassette F12: Slice 7, superior. Cassette F13: Slice 7, inferior. Cassettes F14-F15: Lateral-most margin. Co nsists of multiple soft and firm, Part G, received in formalin and labeled brown-tan and yellow tissue fragments measuring 7 x 6.5 x 1.5 cm in aggregate. The specimen is trimmed and extensively searched for lymph nodes. Multiple candidate lymph nodes are found and submitted intact in cassettes G1-G5.. Signed: Fee Codes: Page 3 of 8
+
+--- Page 4 ---
+Surgical Pathology. Working Draft Addenda Addendum. Date Ordered:. Status:  Signed Out Date Complete:. By: Date Reported:. Addendum Comment An immunohistochemical test for estrogen and progesterone receptors was performed on block F6. The test for estrogen receptors is positive. There is strong nuclear staining in ~50% of tumor cells. The test for progesterone receptors is positive. There is weak to moderate nuclear staining in ~15% Of tumor cells. Resuit of HeR2/neu test: This carcinoma is negative for HEr2/neu oncoprotein over-expression. An immunohlstochemical assay was performed on block F6 using the CB11 monoclonal antibody to HER2/neu oncoprotein. The staining intensity of this carcinoma was 1 on a scale of 0-3.. Carcinomas with staining intensity scores of O or 1 are consldered negative tor over-expression of HER2/neu oncoprotein. Those with a staining intensity score of 2 are considered indeterminate. We and others have observed that many carcinomas with staining intensity scores of 2 do not show gene amplification. All carcinomas with staining intensity scores of 2 are therefore submtted for FiSH testing. The results of the FIsH test are issued directly from the molecular cytogenetics taboratory. Carcinomas with staining intensity scores of 3 are considered positive for over-expression of HER2/neu oncoprotein. Tumors in this category show an excellent correiation between the results of Immunohistochemical and Fish testing, and almost always show gene amplification. The immunnnernvirase stain(s) reoorted above were developed and thelr performance characteristics determined by the The FDA has determined that such clearance or approval is not necessary. These tests are used for clinica! purposes. They should not be regarded as Investigationai or for research. This laboratory is certifled under the Clinical Laboratory Improvement Amendments of 1988 ("cLIA") as qualified to perfarm high-complexity clinical testing.. Electronically signed out on. Other Specimens. Specimen Class: Status: Signed Out Accessioned Signed Out: Specimen(s) Received: Left Breast, Fine Needle Aspiration. Finat Diagnosis Left Breast, Fine Needle Aspiration: I. Benign breast elements (see comment) Paee 4 nf R
+
+--- Page 5 ---
+Surgical Pathology - Norking Draft Specimen Class: Status: Signed Out Accessioned Signed Out: Specimen(s) Received: Vaginal/Cervical/Endocervical, Thin Prep Imaged. Final Diagnosis. Vaginal/Cervicai/Endocervical, Thin Prep Imaged. NEGATIVE FOR INTRAEPITHELIAL LESION OR MALIGNANCY. Atrophic changes. SPECIMEN ADEQUACY: Satisfactory for evaluation. Transformation zone components are present.. _Specimen Class: Status: Signed Out Accessioned Signed Out: Specimen(s) Received: Right Breast, Fine Needle Aspiration. Final Diagnosis Right Breast, Fine Needie Aspiration: Adenocarcinoma, see note. Procedure/Addenda for AddEndUm. Date of Addendum.:. Addendum Comment An immunohistochemical test for estrogen and progesterone receptors as well as for HEr-2-neu was. performed on the material submitted for cell block.. The test for estrogen receptors is positive . There is strong nuclear staining in greater than 9o% of. tumor cells. The test for progesterone receptors is Negative. There is no nuclear staining in 1oo% of tumor cells. Result of HER2/neu test: This carcinoma is negative for HER2/neu oncoprotein over-expression on a scant specimen. Repeat testing is recommended on the excisional specimen. An immunohistochemicai assay was performed on the cell button using the CB11 monoclonal antibody to HER2/neu oncoprotein. The staining intensity of this carcinoma was 1 on a scale of 0-3.. Carcinomas with staining Intensity scores of O or 1 are considered negative for over-expression of HeR2/neu oncoprotein. Those with a stalning intensity score of 2 are consldered indeterminate. We and others have observed that many carcinomas with staining Intensity scores of 2 do not show gene amplification. All carcinomas with staining intensity scores of 2 are therefore. submitted for FIsH testing. The results of the FisH test are issued directly from the molecular cytogenetics laboratory. Carcinomas with staining intensity scores of 3 are considered positive for over-expression of HER2/neu oncoprotein. Tumors in this category show an excellent correlation between the results of immunohistochemical and Fish testing, and almost always show. gene amplification. Pape 5 nf R
+
+--- Page 6 ---
+Surgical Pathology -e Working Draft ihe immunonernxidase staints) reborted above were developed and thelr performdnice chdratleristics deternined by the They have not been cleared or approved by the U. S. Food and Drug Administrauon. Ine rDA has determined that such clearance or approval Is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for research. This laboratory Is certified under the Clinical Laboratory Improvement Amendments of 1988 ("CLIA") as qualified to perform high-complexity clinical testing.. Specimen Class: Status: Signed Out Accessioned Signed Out: Specimen(s) Received: Cervical/Endocervical, Direct Final Diagnosis Cervical/Endocervical, Direct NEGATIVE FOR INTRAEPITHELIAL LESION OR MALIGNANCY. Atrophic changes SPECIMEN ADEQUACY: Satisfactory for evaluation; atrophic pattern with no identifiable. endocervical/transformation zone component. Cellular distortion secondary to airdrying artifact.. Cellular distortion secondary to mechanical artifact.. Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: A: 2:00 Right Breast, Fine Needle Aspiration, B: 5:00 Right Breast, Fine Needle Aspiration Final Diagnosis A. Right Breast, 2:00 o'clock, Fine Needle Aspiration: Lacatation changes; see comment. B. Right Breast, 5:0o o'clock, Fine Needle Aspiration: Lacatation changes; see comment. Specimen Class: Status: Signed Out. Accessioned Signed Out: Specimen(s) Received: Right breast core biopsy Final Diagnosisd Right breast, needle core biopsy: Breast tissue with gestational lobular change and suppurative inflammation; no in situ or invasive carcinoma seen. See comment. pecimen Class: Status: Signed Out Aecessioned: Signed Out: Specimen(s) Received: Right Breast, Fine Needle Aspiration Final Diagnosisd Right Breast. 2:00 o'clock, Fine Needle Aspiration: Atypical, see note. Pare 6 of 8
+
+--- Page 7 ---
+Surgical Pathology - ! Working Draft .. Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Vaginal/Cervical/Endocervical, Thin Prep Final Diagnosis Vaginal/Cervical/Endocervical, Thin Prep NEGATIVE FOR INTRAEPITHELIAL LESION OR MALIGNANCY SPECIMEN ADEQUACY: Satisfactory for evaluation. Transformation zone components are present. Specimen Class: Status: Signed Out Accessionet Signed Out Specimen(s) Received: Uterine contents. Final Diagnosis Uterine contents, evacuation: Decidua with chorionic villi.. Specimen Class: Status: Signed Out Accessioned Signed Out: Specimen(s) Received: Right Breast, Fine Needle Aspiration Final Diagnosis Right Breast, Fine Needle Aspiration: Lipoma; see comment.. Specimen Class: Status: Signed Out Accessioned: Signed Out: Specimen(s) Received: Vaginal, Direct. Final Diagnosis Vaginal, Direct. NEGATIVE FOR INTRAEPITHELIAL LESION OR MALIGNANCY. SPECIMEN ADEQUACY: Satisfactory for evaluation.. Specimen Class: Status: Signed Out Accessioned: Signed Out: : Specimen(s) Received: Vaginal/Cervical/Endocervical, Direct Final Diagnosis Vaginal/Cervical/Endocervical, Direct CELLULAR CHANGES WITHIN NORMAL LIMITS Pape 7 nf 8
+
+--- Page 8 ---
+Surgical Pathology - Working Draft SPECIMEN ADEQUACY: Satisfactory for evaluation. Endocervical cells present END OF REPORT Paze 8 of 8
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+
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+UUID:05334041-D414-4215-9A66-287E4D09F4D5 TCGA-FA-A4BB-01A-PR Redacted Gross Description: In the fatty tissue there are enlarged soft hyperemic lymph nodes up to 3.5 cm in. their diameter. Microscopic Description: Diffuse large B-cell lymphoma. IHC-stainings: CD45 - positive reaction; CD20 positive reaction; CD3 - negative reaction in the tumor cells, positive reaction on the reactive cells; CD30 - positive reaction in some tumor cells. Diagnosis Details: Tumor Features: Indeterminate, Tumor Extent: Disseminated (multifocal) involvement , Venous Invasion: Absent, Margins: Absent, Treatment Effect:. Comments: Extranodal involvement -- liver, spleen. Formatted Path Reports: Lymphoma Checklist ics-0- 3 ymphome, diffuse,1age B-clL Tumor site: Lymph node 9 680/3 Tumor location: Lymph node Sifx: 1y~ph node,axilla C77.3 Tumor size: 3.5 cm dw 9/zu/1 Histological type: Diffuse large B-cell lymphoma Tumor Features: Indeterminate Tumor Extent: Disseminated (multifocal) involvement Extranodal involvement -- liver, spleen. Lymph Nodes: 5/5 positive, axillary, inguina! Venous Invasion: Absent Margins: Uninvolved Additional pathologic findings: IHC-stainings: CD45 - positive reaction; CD20 - positive reaction; CD3 - negative reaction in the tumor cells, positive reaction on the reactive cells; CD30 - positive reaction in some tumor cells..
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index 0000000000000000000000000000000000000000..6259625ec06e7ef48f49b8d2157172bb89e541ff
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+
+--- Page 1 ---
+UUID: BDE9E2A9-09E9-49BC-AFBE-BD32916972DC TCGA-C8-A275-01A-PR Redacted IrB ApprOVeD Multi-media systems inc. Form Revised  Clinica! Case Report 1co-0-3 (For Collection of Cancerous Tissue) carcn om, ifiItnathy Criteri duct, Nos 85oof3 agrois Ds Discrepan Site; breast, Nos cSo.9 hw 3f2ufn Informed Consent 3/20 I personally informed this patient that a specimen(s) would be collected to be used for research. purposes. I reviewed the RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the. consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator. Signature Date Clinical Information RATA GENERALINFORMATIONO Date of Birth (mm/dd/yyyy) Height Marital Status Race Temperature  Single Married S6.sc Gender Weight  Divorced  Widow  Blood Pressure Heart Rate  Male . tFemale 137n m83m  MRAM TTHISTORY OEPRESENT ILLNESS: Chief Complaints: thret baat+ Symptoms: Clinical Findings: rmFy He lTbseat has 3r3 pu-kvd, nnnble tum. ymphnpleere Performance Scale (Karnofsky Score): eul  100 Asymptomatic   80-90 Symptomatic but Fully Ambulatory   60-70 Symptomatic, in bed less than 50% of day.  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden.   20-30 Bed Ridden  CURRENT MEDICATIONS Drug Dose  Route Freguency Date (mm/dd/yyyy) To No To To To
+
+--- Page 2 ---
+ PAST MEDICAL HISTORY Diagnosis Date Treatment Status Diagnosis/Disease/Dlsorder/Injury   .OBGYN HISTORYy a  W Date of First Menses # of Pregnancies Menopausal Status  Pre-menopausal Yeasrd Date of Last Menses # of Live Births  Perl-Menopausal Post-menopausal Yenrsre!  Oral Contraceptive  Hormone Replacementd Birth Controi:  Condom  Other: ND. Therapy: SOCIALHISTORY.. Environmental Hazards: Occupation: Smoking History TYPE Packs/day Duration When Quit Current Status (yrs) (y)  yes Alcohol Consumption. TYPE Drinks/day Duratlon When Quit Current Status (yrs)  (yr)  yes NO Drug Use Duration When Quit Current Status Type Frequency (yrs) 1 (yr)  yes nO SPSFAMILYMEDICALHISTORYL Diagnosis Age of Diagnosis Relative Nohoz Las. Csilx WLABDATA   Result Date  Result Date Test Test CEA   Negative  Positive: Negative  Positive: HIV CA 15-3   Negative  Positive: Negative Hep B  Positive: CA 19-9   Negative  Positive: Hep C   Negative  Positive: PSA  Negative  Positive: AFP   Negative  Positive: Other: Other:  Negative  Positive:  Negative  Positive: B/T Cell Markers:
+
+--- Page 3 ---
++ +**DIAGNOSTIC STUDIES Study Results Date Ultrasound X-Ray CT Endoscopy MRI Biopsy RCAAACLINICALDIAGNOSIS* + Preoperative Clinical Dlagnosis esf heaet Cnen Location of Suspected Involved'Lymph Nodes Location of Suspected Distant Metastasis A xilla No Clinical Staging Date of Diagnosis T9N1 Mo Stage: ICR Treatment Information SMPM.SURGICALTREATMENT Procedure Date of Procedure Haley's swrx? 0 Primary Tumor Organ Detailed Location Size Isea! Eppersnteogsadran 0.9x x cm Extension ot Tumor N Lymph Nodes Description Location of Lymph Nodes # of Lymph Nodes Palpable, Non-Dissected Lymph Nodes A xill 3 Dissected Lymph Nodes Distant Metastasisd Organ Detalled Location Size 190 Surgical Staging Is NA M a Stage: A .  + NEOADJUVENT THERAPY (Chemo, Radiation, Immuno, Hormonal, or Molecular) : Drug/Treatment Dose Route Frequency Date (mm/dd/yyy) To / To 1 To To TQ.
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by: Date: .me: Preserved by:. Date: AA -..ne: :y rrvts p SPECIMEN TYPE (#of samples provided) +   w+ Frozen Paraffin Block Blood/8erum/Plasma Slide Diseased  Normal Diseased  Normal Diseased Normal Diseased Normal x Time to LN2 Time to Formalin. Time to LN2 min M min 60. min RPATHOLOGICALDESCRIPTION Primary Tumor Organ Slze Extension of Tumor Distance to NAT leeay! 19 x* N0 2. cm cm Lymph Nodes Location # Examined # Metastasized Axille 42 Distant Metastasis Size Organ Detalled Location Pathological Staging N m o pTy Stage: JCA Notes:
+
+--- Page 5 ---
+CONSOLIDATED DIAGNOSTIC PATHOLOgy fORm* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION Diffuse  STRUCTURAL PATTERN Streaming Mosaic X.  Storiform Necrosis Lymphocytic Infitration Fibrosis. Vascular Invasion X Palisadin Cystic Degeneration Clusterized X Bleeding Alveoiac Formation X Myxoid Chan? Indian File  PsammomaCalcification 2. Cellular features: Squamous + Adenomatous t. Sarcomatous + Lxmphomatoy! Squamoid Cell Glanduiar ce!l Round Celt Lar. Ceu.  Spindle Cell Cell Stratification Fibroblast Small Cell Keratin Secretion Osteoblast RS CeIVRS Like Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell Pear! Gland fosmation Myoblast  Plasma Cell Otherwise Specified: D7s7 Dr757o Neerm 2. Cellular Differentiation: Well Moderuely Poor X 3.Nuclear Atypia: Nuckear Appearance Aniso Nucleosis Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell x  Mitotic Activity X Nuckear Grade Histological Diagnosis: Enfiltra/s?y. Auttel Csiismpsg N1, C 2 MetRtt8 zed to LN Ms.Careiromo Comments Date Director, Research Pathology PATHOLOGIST STAFF FOR RESEARCH USE ONLY).E *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR ANDS
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+
+--- Page 1 ---
+Clinical Diagnosis & History: with colonoscopy on showed 3cm semi- rcumferential mass 10cm Erom adenocarcinoma. Specimens Submitted:. 1: sp:Right colon; hemicolectomy. DIAGNOSIS: 1. SP:Right colon; hemicolectomy: Tumor Type: Adenocarcinoma with mucinous features (<50% mucinous component) Histologic Grade: Moderately differentiated Tumor Location: Ascending colon Tumor Size: Length is 2.1 cm Width is 2.8 cm Maximal thickness is 0.4 cm Tumor Budding: Absent Increased Tumor Infiltrating Lymphocytes:. Absent Precursor Lesions: Tubular adenoma Deepest Tumor Invasion: Subserosal adipose tissue and/or mesenteric fat. Gross Tumor Perforation:. Not identified Lymphovascular Invasion: Identified Large Venous Invasion: Not Identified Perineural Invasion:. Not identified Surgical Margins: Free of tumor Polyps/Mucosa Dysplasia (away from the carcinoma): Not Identified ** Continued on next page **
+
+--- Page 2 ---
+Non-Neoplastic Bowel: Unremarkable Appendix: Unremarkable Lymph Nodes: Number with metastasis: 0 Total number examined: 31 Tumor deposits in pericolorectal soft tissue: Not Identified Tumor Staging (AJcc 7th Edition): pT3 (Tumor invades through the muscularis propria into. pericolorectal tissues) Lymph Node Stage (AJcc 7th Edition): N0 (No regional lymph node metastasis) I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. 1). The specimen is received fresh, labeled "Right colon" and consists of a segment of terminal ileum, cecum with attached appendix and ascending colon. The terminal ileum measures 12.0 cm in length and 3.6 cm in circumference at the proximal resected margin. The remaining colon measures 14.0 in length with a circumference of 5.4 cm at the distal resected margin.. The attached appendix measures 5.8 cm in length and averages 0.7 cm in diameter. The appendiceal and intestinal serosa is pink tan and smooth.. Focally hemorrhagic lobulated yellow tan adipose tissue spans the length of the. specimen measuring up to the 3.8 cm in thickness. The specimen is opened to reveal a mass lesion measuring 2.1 cm in length and 2.8 cm in width. The mass is located in the right colon, 3.8 cm distal to the ileocecal valve, 17.0 cm from the proximal margin and 6.5 cm from the distal margin.. Sectioning shows that the tumor invades the underlying muscularis. The depth of invasion is 0.5 cm grossly. The remaining mucosa is remarkable for a 0.7 x 0.1 to 0.4 cm sessile polyp 1.0 cm distal to the tumor.  The attached adipose tissue is thoroughly examined and all identified lymph nodes are submitted. Representative sections of the specimen are submitted for permanent sections and for Tps. Summary of sections: p - proximal margin shave D- distal margin shave r tumor A - appendix representative sections ** Continued on next page **
+
+--- Page 3 ---
+Page3 of3 PL-polyp RS -representative sections LN-lymph nodes BLN -bisected lymph nodes Summary of Sections: Part1 SP:Right colon; hemicolectomy Block Sect. site PCs 12181113 RA 12 DV LN P 1 PL 11 RS 3 * End of Report
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+Clinical Diagnosis & History: y/o female with right lower inner quadrant carcinoma Idc/Dcis with. microcalcifications. Right 3:00 -> IDC poorly differentiated; DcIs with UUID: 3023C34B-CF59-43EA-9241-333738D19805 microcalcification. TCGA-AO-A03M-01A-PR Redacted Specimens Submitted: 1: SP: Senitnle node #1, level one, right axilla (fa* 2: SP:  Sentinel node #2, level one, right axilla (f: 3: sp: Sentinel node #3, level two, right axilla (fs 4: SP: Right breast and axillary contents levels 1, 2 and 3 DIAGNOSIS: 1) LYMPH NODE, SENTINEL #1 LEVEL I RIGHT AXILLA; BIOPSY: - METASTATIC CARCINOMA IN ONE OUT OF SIX LYMPH NODES (1/6).  THERE IS NO EXTRANODAL EXTENSION OF CARCINOMA. 2) LYMPH NODE, SENTINEL #2 LEVEL I RIGHT AXILLA; BIOPSY: - METASTATIC CARCINOMA IN ONE OF ONE LYMPH NODE (1/1). (SEE NOTE))  NO EXTRANODAL EXTENSION SEEN. NOTE: THE METASTASIS IS PRESENT ON DEEPER LEVEL PERMANENT SECTION ONLY. 3) LYMPH NODE, SENTINEL #3 LEVEL II RIGHT AXILLA; BIOPSY: -TWO BENIGN LYMPH NODES 0/2). 4) BREAST AND AXILLARY CONTENTS, RIGHT LEVELS I, II, AND III; MASTECTOMY : - MULTIPLE FOCI OF INVASIVE DUCTAL CARCINOMA, NOS TYPE, HISTOLOGIC GRADE III/III (SLIGHT OR NO TUBULE FORMATION). NUCLEAR GRADE III/III (MARKED VARIATION IN SIZE AND SHAPE), RANGING IN SIZE FROM O.1 CM UP TO 3 CM. - DUCTAL CARCINOMA IN SITU (DCIS) IS ALSO IDENTIFIED, SOLID, CRIBRIFORM, AND MICROPAPILLARY TYPES WITH HIGH NUCLEAR GRADE AND MODERATE NECROSIS. - LOBULAR INVOLVEMENT BY DCIS IS PRESENT. - THE DCIS CONSTITUTES 5- 25% OF THE TOTAL TUMOR MASS, AND IS PRESENT ADMIXED WITH AND AWAY FROM THE INVASIVE COMPONENT. - THE INVASIVE CARCINOMA IS LOCATED IN THE LOWER OUTER QUADRANT AND LOWER INNER QUADRANT. - THE DCIS IS LOCATED IN THE LOWER OUTER QUADRANT AND LOWER INNER QUADRANT. - DCIS INVOLVES THE LARGE LACTIFEROUS DUCTS. ** Continued on next page ** Jcs-0-3 Circuiona nifilfrntwg duct,1vos 850of3 Site : buast, Nos c5o.9 Y0/22/+!
+
+--- Page 2 ---
+-- Page 2 of 5 - CALCIFICATIONS ARE PRESENT IN BOTH THE IN SITU AND INVASIVE CARCINOMA. VASCULAR INVASION IS PRESENT.  NO INVOLVEMFNT OF THE SURGICAL MARGINS BY INVASIVE CARCINOMA IS IDENTIFIED. - RARE FOCI OF DCIS/IN SITU CARCINOMA ARE CLOSE (1 MM) TO THE FOLLOWING SURGICAL MARGIN: DEEP. NO SKIN INVOLVEMENT BY CARCINOMA IS IDENTIFIED. THE ATTACHED SKELETAL MUSCLE IS NEGATIVE FOR TUMOR.  THE NON-NEOPLASTIC BREAST TISSUE SHOWS BIOPSY SITE CHANGES. THE LYMPH NODE STATUS IS AS FOLLOWS (EXPRESSED AS THE NUMBER OF POSITIVE LYMPH NODES IN RELATION TO THE TOTAL NUMBER OF LYMPH NODES EXAMINED) : LEVEL I: 0/13; LEVEL II: 0/9; AND LEVEL III: 0/2. - RESULTS OF SPECIAL STAINS (ER, PR, HER2-NEU) WILL BE REPORTED AS AN ADDENDUM. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. cronically Signed Out * Special Studies: Result Special Stain ER-C PR-C HER2-C IMM RECUT NEG CONT Gross 1. The specimen is received fresh for frozen section consultation, labeled "Sentinel node number one, level 1, right axilla" and consists of 7 lymph nodes and measure 3.5 x 2.6 x 1.0 cm in aggregate. One lymph node is blue and has been bisected, and the lymph nodes are entirely submitted in two cassettes Summary of sections: FSCA--frozen section control A FscB--frozen section control B. 2). The specimen is received fresh for frozen section consultation,. labeled "Sentinel node number two, level 1, left axilla" and consists of a soft lymph node measuring 0.6 x 0.5 x 0.5 cm, bisected and entirely submitted for frozen section. Summary of sections: ** Continued on next page **
+
+--- Page 3 ---
+FSC-frozen section control PA 3. The specimen is received fresh for frozen section consultation, labeled "Sentinel node number three, level 2, right axilla" and consists of two soft tan lymph nodes totaling 2.0 x 1.2 x 0.6 cm, entirely submitted for frozen section. Summary of sections: MD 4). The specimen is received fresh in a container, labeled "Right breast and axillary contents levels 1, 2 and 3 with tags attached". The specimen consists of a mastectomy measuring 30 x 19 x 3 cm..  That axillary tail measures 13 x 8 x 2 cm. The overlying ellipse of skin measures i0 x 3 cm.. No scar can be identified on the skin. The nipple measures 1 x 1 cm and it is grossly unremarkable... The deep resection margin is inked blue.. specimen is serially sectioned revealing a pinkish red, relatively The well-circumscribed and firm lesion measuring 3 x 1.5 x 1 cm which closely abuts the inked resection margin. The lesion is 2 cm away from the skin. The lesion is located in the iower inner quadrant. Surrounding the lesion,. are areas of fibrosis which show punctate areas of cheesy necrosis. Away from this lesion, in the lower outer quadrant is a vaguely defined area of fibrosis and nodularity. Approximate measurements of this area are 10 x 6 cm.  The upper inner and outer quadrants show mainly fatty tissue. axillary dissection is performed revealing 3 level one lymph nodes, 4 level An two lymph nodes and 2 level three lymph nodes. Summary of sections: TRM-tumor in relation to inked resection margin. TRs-tumor in relation to skin. LIQ-lower inner quadrant. LOQ-lower outer quadrant UOQ-upper outer quadrant UIQ-upper inner quadrant N-nipple L1-level one lymph nodes L2-level two lymph nodes L3-level three lymph nodes. Summary of Sections:. Part 1: SP: Senitnle node #1, level one, right axilla (fs) ( Block Sect. site PCs 1 {not entered} 1 1 fsc 1 Continued on next page *1.
+
+--- Page 4 ---
+Part '2: SP: Sentinel node #2, level one, right axilla (fs) Block Sect. site pCs 1 fsc 1 Part 3: SP: Sentinel node #3, level two, right axilla (fs) Block Sect. Site. pCs fsc 1 Part 4: SP: Right breast and axillary contents levels 1, 2 and 3 Block Sect. site PCs 1 11 1 1 12 1 1 13 1 11 liq 11 15 1oq 15 1322 n 1 trm trs uiq uoq 1 Procedures/Addenda: Addendum Date Ordered: Status: Signed Out Date Complete:a By: Date Reported: Addendum Diagnosis ADDENDUM SITE; RIGHT BREASTS PART #4. ER 90% OF NUCLEAR STAINING WITH MODERATE INTENSITY. PR: 1% OF NUCLEAR STAINING WITH MODERATE TO WEAK INTENSITY. HER2/NEU (HERCEPTEST) : POSITIVE (STAINING INTENSITY OF 3+). MD Intraoperative Consultation: Note: 'The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. ** Continued on next page **.
+
+--- Page 5 ---
+FROZEN SECTION DIAGNOSIS: METASTATIC CARCINOMA (SLIDE B) . SAME 2) FROZEN SECTION DIAGNOSIS: NEGATIVE LYMPH NODE PERMANENT DIAGNOSIS: SEE FINAL DIAGNOSIS 3) FROZEN SECTION DIAGNOSIS: NEGATIVE LYMPH NODE PERMANENT DIAGNOSIS: SAME ** End of Report
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diff --git a/output/text/bb8595bd-84ab-4cbb-953e-5cd6766270c9.txt b/output/text/bb8595bd-84ab-4cbb-953e-5cd6766270c9.txt
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+Clinical Diagnosis & History: y/o male with right renal mass. Specimens Submitted: 1:KIDNEY AND PORTIONOF ADRENAL,RIGHT,NEPHRECTOMY 2:LYMPHNODES,PARACAVALANDPERICAVAL,EXCISION AMENDED DIAGNOSIS: 1.KIDNEY AND PORTION OF ADRENAL,RIGHT,NEPHRECTOMY: Tumor Type: Renal cell carcinoma-Chromophobe type Tumor Size Greatest diameter is 6.5 cm. Local Invasion (for renal cortical types): Involves renal sinus fat Renal Vein Invasion: Not identified Tumor involves medium caliber vessels in the renal sinus Surgical Margins Free of tumor Non-Neoplastic Kidney: Unremarkable Adrenal Gland: Not involved Lymph Nodes: Not identified Staging for renal cell carcinoma/oncocytoma: pT3 Tumor extends into major veins or invades the adrenal gland or perinephric tissues,but not beyond Gerota's fascia 2.LYMPH NODES,PARACAVAL ANDPERICAVAL,EXCISION: Lymph Nodes: Not involved Page 1of4
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT Number of nodes examined:6 Note: This document represents an amended version of the surgical pathology report originally issued on That report is superseded by the present document.The amendment consists of the following change: Specimens Submitted: ORIGINAL REPORT: 1:KIDNEY AND PORTION OF ADRENAL,LEFT,NEPHRECTOMY AMENDEDREPORT: 1:KIDNEY AND PORTION OF ADRENAL,RIGHT,NEPHRECTOMY The responsible clinician has been notified. IATTEST THAT THE ABOVE DIAGNOSIS IS BASEDUPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL).AND THAT IHAVE REVIEWED AND APPROVED THIS REPORT. Gross Description: 1). The specimen is received fresh labeled "right kidney and portion of adrenal' and consists of a kidney with attached ureter,renal vessels and perinephric fat weighing240 g in total.The kidney measures 13 x 7 x 5.5 cm.The attached ureter measures 4.5 cm in length and 0.2 cm in diameter. The attached renal vein measures 1.4 cm in length and 0.4 cm in diameter. The renal vessels and ureter margins are grossly unremarkable.An adrenal gland is not identified.The kidney is inked black and bivalved to reveal a well defined tumor mass measuring 6.5 x 4 x 4 cm,located in the calluses and extend to the hilum. The biliary tract is not involved by the tumor.The tumor has a homogenous yellow tan rubbery to soft cut surface.A portion of unremarkable adherent gland is identified measuring 1.3 x 1 x 0.5 cm. Sections through the remainder of the kidney reveal a pink brown parenchyma, with a well-defined cortico-medullary junction. The cortex measures 0.7 cm.No lymph nodes are identified in the perinephric fat. Representative sections are submitted for TPS and for permanent sections.Photos are taken. Summary of sections UVM--ureteral and vessel margins T-tumor THF--tumor with hilar fat TSF--tumor with sinus fat TK-- tumor with adjacent kidney RP--renal pelvis representative sections K-- representative sections kidney A-adrenal 2).The specimen is received in formalin,labeled Paracaval and pericaval lymph nodes" and consists of six pink tan firm lymph nodes ranging from 1 to 2.7 cm in greatest dimension.All identified lymph nodes are submitted. Summary of sections: LN-lymph nodes BLN--bisected lymph nodes Summary of Sections: Page 2of4
+
+--- Page 3 ---
+SURGICAL PATHOLOGY REPORT Part 1:KIDNEY AND PORTION OF ADRENAL,RIGHT,NEPHRECTOMY Block Sect.Site PCs 1 a 2 2 2 rp 2 4 t 4 2 thf 2 2 tk 22 2 tsf 1 uvm 1 Part 2:LYMPH NODES,PARACAVAL ANDPERICAVAL,EXCISION Block Sect.Site PCs 3 BLN 4 2 LN 4 Amendments Original Diagnosis: 1.KIDNEY ANDPORTIONOF ADRENAL,LEFT,NEPHRECTOMY: Tumor Type: Renal cell carcinoma-Chromophobe type Tumor Size: Greatest diameter is 6.5 cm. Local Invasion (for renal cortical types): Involves renal sinus fat Renal Vein Invasion: Not identified Tumor involves medium caliber vessels in the renal sinus Surgical Margins: Free of tumor Non-Neoplastic Kidney: Unremarkable Adrenal Gland: Not involved Lymph Nodes: Not identified Staging for renal cell carcinoma/oncocytoma: pT3 Tumor extends into major veins or invades the adrenal gland or perinephric tissues,but not beyond Gerota's fascia 2.LYMPH NODES,PARACAVAL AND PERICAVAL,EXCISION: Lymph Nodes: Page 3 of4
+
+--- Page 4 ---
+SURGICAL PATHOLOGY REPORT Not involved Number of nodes examined:6 Page4of4 ENDOF REPORT
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+UUID:CB9B68D7-7628-4828-9479-4ECFE346AB5C TCGA-OR-ASK6-01A-PR Redacted Specimen Date/rime: DIAGNOSIS (A) LEFT ADRENAL TUMOR: ADRENOCORTICAL CARCINOMA (8.O CM IN GREATEST DIMENSION), CONFINED TO THE ADRENAL GLAND. (SEE COMMENT)A Margin of resection, no tumor present. COMMENT. This large tumor shows diffuse growth pattern with extensive necrosis, and the tumor cells show focal areas of Fuhrman nuclear. grade 3. Clear cells compromise less than the 25% of tumor cells. There are.7 mitotic figures in 50 high-power fields. The overall. features are consistent with adrenocortical carcinoma.. was consulted. GROSS DESCRIPTION (A) LEFT ADRENAL TUmOR - A left adrenalectomy, 8.0 x 5.5 x 5.0 cm, weighing 0.15 kg., with attached adipose tissue. There is a separate portion of unremarkable adipose tissue, 2.5 x 2.5 x 1.0 cm.. The adrenal gland is nearly entirely replaced by a well circumscribed encapsulated tumor, 8.0 cm in greatest dimension.. The cut surfaces are variegated, yellow, tan and red with friable hemorrhagic areas (approximately 40% of the tumor). The tumor abuts the capsule and adjacent adipose tissue.. There is minimal residual normal adrenal cortex and medulla. INK CODE: Black - surface of adrenal gland.. SECTION CODE: A1-A3, hemorrhagic, friable areas of tumor with margin; A4, A5, tan firm areas of tumor; A6-A8, yellow areas of tumor with adjacent adipose tissue; A9, A10, tumor with adjacent residual adrenal tissue; A11, A12, representative residual adrenal tissue. IcD-o-3 CLINICAL HISTORY Av'cinsmo-, adreual corticala 8370/3 None given. Bite: AdveualGland ,eortex CONSULTANT(S) Q 74.D HtS 1/3u/13 SNOMED CODES T-83000, M-83703 "Some tests reported here may have been developed and pertormance characteristics determined by hese tests have not teen specifically cleared or approved by the U.S. Food and Drug Administration.".
+
+--- Page 2 ---
+Page: Specimen Date/Time: ADDENDUM This modified report is being issued to provide comment on immunohistochemical study. The original diagnosis remains unchanged. Addendum completed bv COMMENT Immunostain for Ki-67 (a proliferative marker) was performed. About 4221 cells are evaluated using an Image Analysis System, 6.8% of the evaluated cells are positive for Ki-67. --END OF REPORT--. 1222
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diff --git a/output/text/bc193e58-693c-47ef-8822-faac28ec3c18.txt b/output/text/bc193e58-693c-47ef-8822-faac28ec3c18.txt
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+FINAL DIAGNOSIS: Part 1: Lymph node, Left sentinel #1, biopsy -- ONe LymPH NODE, FREE OF TUmOR (O/1). Part 2: Lymph node, Left Sentinel #2, biopsy - One lymph node, free Of tumor (0/1). Part 3: breast, Leet, segmental mastectomy - A. _ iNeIL TRATiNG DUcTaL. CArcINQmA (3A, 3B, 3C, 3D, 3E, AnD 3F). THe TUmOR COmES tO WITHIN 1.0 Mm FrOm THe NEAREST AnTERiOR RESECTION mARGiN (3A AND 3B). B. THE TUMOR SIZE IS 1.5 X 1.2 X 1.1 CM. c. NOTTiNGHAM SCORE IS 6/9 (TUBULES 3, NUCLEI 2, MITOSIS 1). D. LYMPHOVASCULAR PERMEATION iS NOT APPRECIATED. E. DUCTAL CARCINOMA IN SITU, CRIBRIFORM AND SOLID TYPES, NUCLEAR GRADE 2, REPRESENTING ABOut 2% Of tumOR VOlumE. F. DUCTAL CARCINOMA iN SITU IS ADMIXED WITH INVASIVE TUMOR AND COMES TO WITHIN 1.0 MM FROM THE NEARESt ANTeRIOR RESECTION MARGIN. G. CHANGES CONSISTENT WITH PREVIOUS BIOPSY SITE, SEE PRIOR H. FIBROCYSTIC CHANGES WITH FIBROADENOMATOID CHANGES, DUCTAL EPITHELIAL HYPERPLASiA,S COLUMNAR CELL CHANGES AND ASSOCIATED MULTIFOCAL MICROCALCIFICATIONS. immUnOhIStOchemICAL STAInInG fOR ESTrOgen REcEptOR, PrOgEStErOne RECEptOR AnD hER- 2/NEU WERE PREVIOUSLY PERFORMED ONS AND WERE REPORTED AS FOLLOWS: EstrOgen rEceptOr -- pOsitive, progeSterOne rEceptOr -- pOsitive, her-2/neU -- negatIve (SCORE +1). Part 4: Lymph node, Left sentinel #3, BiOpsy - 1cs-s -3  One lymph nOde, fRee Of tumOr (0/1). Cucnm, nfyiltnaHvj ouctl nos 850of3 Part 5: Lymph node, Left sentinel #4, biOpsy - Sit: brost ss03 ONe Lymph nODe, fRee Of tumor (0/1). c5s.9 3/13fu h CASE SYNOPSIS:  SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST LATERALITY: PROceDUrE: Left Segmental LOcATIOn: Not specified SIZE OF TUMOR: Maximum dimension invasive component: 1.5 cm MULTICENTRICITY/MULTIFOCALITY OF iNVASIVE FOCI: No TUMOR TYPE (invasive component): Ductal adenocarcinoma, NOS UUID: 06602AD0-AC4D-4674-B4B0-2D207C3E78DC NOTTINGHAM SCORE: TCGA-BH-A0B6-01A-PR Redacted Nuclear grade: 2 Tubule formation: 3 Mitotic activity score: 1 Total Nottingham score: 6 Nottingham grade (1, 2, 3): 2 ANGIOLYMPHATIC INVASION: No DERMAL LYMPHATIC INVASION: Not applicable CALCIFICATION: Yes, benign zones Tumor type, in situ: Cribriform, Solid, DCiS admixed with invasive carcinoma, Percent of tumor occupied by in situ component: 2 % SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No Distance of invasive tumor to closest margin: 1 mm SURG MARGINS INVOLVED BY IN SITU COMPONENT: No Distance of in situ disease to closest margin: 1 mm LYMPH NODES POSITIVE: LYMPH NODES EXAMINED: 0 METHOD(S) OF LYMPH NODE EXAMINATION: 4 NON-NEOPLASTIC BREAST TISSUE: Fibroadenoma, FCD H/E stain t stage, patholOgic: N stage, pathologic: pT1c m Stage, patholOgiC: pN0 ESTROGEN RECEPTORS: pMX PROGESTERONE RECEPTORS: positive HER2/NEU:  positive zero or 1+ y3/1
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diff --git a/output/text/bc46f341-e3cc-4f27-9401-410bb5728bfe.txt b/output/text/bc46f341-e3cc-4f27-9401-410bb5728bfe.txt
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+1c0-0-3 Adeno cerceiomo, mfiYtrahay duect 8500/3 Site: breast, Nos c50.9 Phone 1/21/ h SURGICAL REPORT Pathology Number: Name: Date Collected: : Sex: F Date Received: : DOB: M.R. Number: Location: Account Number Doctor: PrE-OPERATIVe DIAGNOSIS LEFT BREAST CANCER post-OperAtIve DiAGnosIS LEFT BREAST CANCER PROCEDURE LEft BREAst LumpeCtOmy WITh AxiLLAry Lymph nODe DiSsectiON TISSUES A. BREAST EXCISION,NEEDLE LOC,SIMPLE,MARGINS,ETC. - LEFT B. AXILLARY - CONTENTS LEFT C. AXILLARY - ADDITIONAL CONTENTS LEFT D. MARGINS - ADDITIONAL LATERAL E. MARGINS - ADDITIONAL MEDIAL ADDeNDum 2 HER-2 (IHC) -- 0 Not amplified. UUID:6F5EBE67-0A25-4B20-A1F6-9CE6C4FF4096 SPECIAL STAINS PERFORMED: Her-2 (IHC) (HA) TCGA-A2-A0T0-01A-PR Revlewed and electronlcally signed out by: ADDENDUM ESTrOGen AND pROgESTeROne RECepTOR RESuLTS: Estrogen receptors -- NEGATIVE IN THE MALIGNANT CELLS (0%). Progesterone receptors --  NEgative in The mAliGnant CElls (0%). Comment: The contro! tissues for Estrogen and Progesterone Receptor Immunohistochemical Studies display appropriate staining pattern. Reviewed and electronicaly signed out by: Pathology Number: Patlent Name: RECEVED3 SURGICAL REPORT
+
+--- Page 2 ---
+Pathology Number: Patient Name FS DIAGNOSIS Left breast Lump (grOss margins) - A. pOrtiOn Of breAst tissue with tumor (3.2 X 3.1 X 3.0 Cm.) extending tO LATERAl SURGICAL MARgiN AND WIThIN 0.1 CM. Of THe MeDIAL SUrgICAL MARGINS. ALL Of ThE REmAINIng DESIgNATeD SUrgICAl MArgINS ARe WiThin 0.5 CM. Of the tumor (gross). (reported to surgeon: Diagnosed by: FiNAL DIAGNOSIS A. Left breast Lump - BreAst tiSsue DispLAyIng inVasive pOOrLy DIffErenTiated Ductal AdenocarcinomA Of the breast, 3+3+3, 3.2 Cm. IN greatest DimensiOn. TuMOR eMBOlI SEEN IN AngIOlyMPhATIC SPACES. MARGINS ARE FREE The neArest mArgIn is 0.1 Cm. tO the tumOr As reported in the grOss EXAMiNATION. B. Axillary contents Left - LymPh nODE, MeTASTATIC DUcTAL ADeNOCARCinOMA in TWO LymPH NODES frOm A tOtal Of TWeLVe Lymph nODes (212). The Largest node wIth tumor is 1 Cm. In greatest DimensIon. THe tumOr tOtalLy OccupIes the NOde with extracApsulAr Extension to the fat. C. Additional AxillAry Contents, Left  Lymph nodes, two reactive. D. ADDItIONal LATerAl MArGins - fiBrOadipOse tissue And breast tissue, no tumor Seen; however, there iS  MIcrOscOpic fOcus Of tumOr emBOli SEen In AngIOlymphatic SpAces. E. ADDITIONAL MEDIAL MARGINS -- Fibroadipose tissue and breast tissue, no tumor seen. PTNM CLASSIFICATION: T2 N1 MX, Stage Ii8, Ductal ADenOcarcInOmA, g3. PqrI CateGORy II: 3260F. Diagnosed by: Reviawed and electranir COMMENT This case is discussed with Pathology Number: Patlent Name Page 2 of 3 SURGICAL REPORT
+
+--- Page 3 ---
+Pathology Number: Patient Nam Gross DescrIpTIOn Jesignated A The specimen is received in five separate containers labeled. through E. A. The container is received fresh unfixed labeled "left breast lump" and consists of a 30 gm. ovoid mass of apparent fatty and fibrous-encased tissue which is 4.5 x 3.5 x 2.8 cm. in greatest overall dimension.' There is a single short suture indicating superior margin inked with orange, inferior is inked red. There is a single long suture indicating lateral margin inked with black dye, medial is inked blue. There are two short sutures indicating anterior margin inked with green dye, deep is inked yellow. Sectioning reveals a tumor, a gray-white irregular bordered tumor which is 3.2 x 3.1 x 3 cm. in greatest overall dimension and has scattered yellow-tan chalky areas varying up to 0.3 cm. in greatest dimension and a central O.4 cm. slightly gelatinous hemorrhagic area. The tumor mass grossly appears to involve the lateral/black margin is 0.1 cm. from the medial/blue, 0.5 cm. from the anterior/green, 0.5 cm. from the deep/yellow, 0.5 cm. from the superior/orange and 0.5 The entire specimen is. cm. from the inferior/red. Gross margins are obtained by Dr.. submitted in seventeen blocks.. Key Note Block Summary: 1---lateral/black, 2--medial/blue, 3--- anterior/green, 4-. deep/yellow, 5---superior/orange, 6---inferior/red (all are perpendicular), 7 through 17---remaining B. The container is received fixed labeled "left axillary contents" and consists of an irregular mass of apparent fat 3.5 x 3 x 2.5 cm. Sectioning reveals pink-tan nodules varying up to 2 cm. in greatest dimension. The iarger nodes are hemisected and placed in cassettes 2 through 5. C. The container is received fixed labeled "additiona! axillary contents" and consists of an irregular mass of apparent fatty tissue which is 1 x 0.6 x 0.4 cm. Sectioning reveals a 0.4 cm. pink-tan nodule. The entire specimen is submitted as one section in one block. D. The container is received fresh unfixed labeled "additional iateral margin' and consists of an 8 gm. ovoid mass of apparent fatty and fibrous encased tissue is 3 x 2.5 x 2 cm. in greatest overall dimension. There is an attached suture indicating new lateral margin inked with red dye. Sectioning reveais fat and a scant amount of fibrous tissue. The entire specirnen is subnitted in four blocks. E. The container is received fresh unfixed labeled "additional medial margin - suture on new medial margin" and consists of an 8 gm. ovoid mass of apparent fatty and fibrous encased tissue is 3 x 3 x 2.5 cm. in greatest overall dimension. There is a suture indicating new medial margin inked with blue dye. The entire specimen is submitted in four blocks.. MICROSCOPIC EXAM MICROSCOPIC EXAMINATION CONDUCTED BY PATHOLOGIST CONFIRMS FINAL DIAGNOSIS. Pathology Number:. Patient Nar SURGICAL REPORT Page 3 of 3
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diff --git a/output/text/bc560667-11da-4a45-9654-d83d17d60cc9.txt b/output/text/bc560667-11da-4a45-9654-d83d17d60cc9.txt
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+Diagnosis: Right-sided hemicolectomy preparation shows tumor-free oral and aboral resection margins and includes an ulcerated, moderately differentiated adenocarcinoma of the transverse colon with infiltration of the perimuscular fatty tissue (G2, pT3). Follow-up report: After acetone clearing, 21 lymph nodes up to 0.7 cm in size can be prepared in the pericolic fatty tissue adjoining the tumor. Of these, one lymph node shows metastatic infiltrates of the previously diagnosed adenocarcinoma or colon carcinoma. In conclusion, to summarize, the disease is staged as pT3 pN1 (4/21) L0 V0 R0.
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diff --git a/output/text/bc587279-18cf-40a4-ab7b-32ca5a489509.txt b/output/text/bc587279-18cf-40a4-ab7b-32ca5a489509.txt
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+--- Page 1 ---
+PREVIOUS DIAGNOSIS INQUIRY UUID:90A9556D-C417-4FD8-AE1C-7AC89F60E444 TCGA-OR-A53Z-01A-PR Redacted PAGE#: SEX:M PAT TYPE: ADM DATE: OPER DATE: PROCEDURE: SPHS Left adrenal mass. Operative Procedure/tissue Submitted: Left adrenal mass excision. PROCEDURE: SPGD 1. "Liver capsule, rule out metastatic adrenal cancer." A 0.5 cm, red-brown tissue fragment with a 0.1 cm white nodule. Frozen section control.. 2. "Left adrenal gland with retroperitoneal fat, two short stitches equals Superior, one long stitch equals lateral, two long stitch equals posterior". Received fresh for tissue procurement in a large container is a 585 gram (untrimmed weight), 17.2 x 12.5 x 5.4 cm mass with attached fat oriented as above. The mass itself measures 8.5 x 8.5 x 6.2 cm and grossly appears well encapsulated. Inked as per standard inking template. Untrimmed weight is 370 grams. Attached to the mass is a 5.5 x 1.0 cm adrenal gland. The cut surfaces Show yellow soft focally hemorrhagic cut surfaces. The normal adrenal gland IeD-6-3 has an orange cortex and a brown medulla. The mass grossly appears to arise 2A and B. Tumor to adrenal gland to include anterior and medial margins. 113 2c. Tumor to include tateral margin. 2D. Tumor to include superior margin. 2E. Tumor with area of hemorrhage. No margins. 2F. Tumor to adjacent adrenal gland. 2G. Tumor to capsule. 2H. Additional representative section of tumor. No margin.. 21. Tumor to capsule. 2J. Representative sections of inferior and posterior margins from the attached fat. 3. "Left perirenal fat". Received in a mediun container of formalin is a 7.5 x 4.4 x 0.4 cm piece of fibrofatty tissue with homogenous yellow cut surfaces. No lesions present. Representative sections in one cassette. 8370/  74.Z FROZEN SECTION REPORT 1. Fibrotic nodule with necrotic debris. Permarent sections confirm frozen section report.. PROCEDURE: SPM1 ADRENOCORTICAL CARCINOMA
+
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+ PREVIOUS DIAGNOSIS INQUIRY PAGE #: 2 REPORT OATE: 4 SEX:M PAT TYPE: ADM DATE: BIRTHDATE: OPER DATE: Tumor size: 8.5 x 8.5 x 6.2 cm Tumor Weight: 370 grams Capsular Invasion: Present Vascular Invasion: Absent Surgical Margins:!. Negative Necrosis: Present, focal (5%) Mitotic Rate: 5/50 hpf Grade: Low grade Lymph nodes status:. N/A Extra-adrenal extension: No Stage: T2 Nx Mx Immunohistochemistry Results: See coMmenT. PROCEDURE: SPDX 1. Liver capsule, biopsy: Negative for neoplasm. 2. Left adrenal gland, resection: low grade adrenocortical carcinoma (8.5 cm), confined to the adrenal. Surgical margins negative. See TEMPlAte above and COMMENT bel ow. 3. Left perirenal fat, excision: Benign fibroadipose tissue.. COMMENT This carcinoma appears to be arising from a pre-existing adrenocortical. adenoma, present on the periphery. The tumor cells show patchy positive. staining for synaptophysin, melan-A, and inhibin; rare positive staining for cytokeratin, and negative staining for chromogranin and s-100. MI8-1 shows a proliferative index of approximately 20%. These results support a diagnosis of low grade adrenocortical carcinoma.
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diff --git a/output/text/bc5b3a20-7922-485b-a67e-63c8857f3f89.txt b/output/text/bc5b3a20-7922-485b-a67e-63c8857f3f89.txt
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+UUID:47D02B80-47DA-4135-A288-21077C5947A9 tcgA-S3-A6Zg-01A-pr Redacted MRN: Sex/DOB: Female Patient: Admission Date: Discharge Date: Ordering Physician: Pathology Addendum Report Collected Date/Time: Accession Number: Received Date/Time: Addendum Report Immunohistochemical studies were performed on formalin fixed, paraffin-embedded tissue (Blocks A1, A2) with adequate positive. and negative control sections. Immunohistochemical stains for keratins AE1/AE3 are negative for carcinoma.. The performance characterictice of these antibodies were determined by the  'hey have not been cleared or approved by the U.S. Food and Drug Admun:stration. I ne +DA has determined that such. clearance or approval is not necessary. Thesc iests are used for clinical purposes. They should not be regarded as investigational or for research. This laboratory is certificd under the Clinical Laboratory Improvement Amendments of 1988 (CLIA-88) as qualified to perform high-complexity clinical laboratory testing.. C6cF IcDo-3 iyisttsete uenomn, 10Uv\ar 85z0|3 + (Electronic signature) u|z0|l3 Verified: 8s2z)3 Surgical Pathology Report Collected Date/Time: Accession Number: Received Date/Time: Final Diagnosis A. LEFT SENTINEL LYMPH NODES, EXCISION: - METASTATIC CARCINOMA (MACROMETASTASIS) IN ONE OF THREE LYMPH NODES WITH FOCAL EXTRACAPSULAR EXTENSION (1/3). B. LEFT BREAST, EXCISION: Printed by: Page l of 6 Print Date/Time: Copied to: Patient Locations: Distribute to:
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+--- Page 2 ---
+MRN: Patient: Sex/DOB: Female Surgical Pathology Report Collected Date/Time: Accession Number: Received Date/Time: - INVASIVE MIXED DUCTAL AND LOBULAR CARCINOMA, GRADE 2, MEASURING 2.1 CM IN GREATEST DIMENSION, EXTENDING TO 0.5 MM FROM THE MEDIAL AND TO 1 MM FROM THE POSTERIOR RESECTION MARGINS OF THE SPECIMEN, WITH LYMPHOVASCULAR AND PERINEURAL INVASION. - CARCINOMA IN-SITU WITH MIXED DUCTAL AND LOBULAR FEATURES, NUCLEAR GRADE 2, WITH FOCAL NECROSIS, EXTENDING TO 1.8 MM FROM THE POSTERIOR RESECTION MARGIN OF THE SPECIMEN. - ATYPICAL LOBULAR HYPERPLASIA.  - SEE SYNOPTIC REPORT AND SPECIAL STAINS SECTION. (Electronic signature) Verified Synoptic Report SPECIMEN: Partial breast PROCEDURE: Excision without wire-guided localization LYMPH NODE SAMPLING: Sentinel lymph node(s) SPECIMEN INTEGRITY Single intact specimen (margins can be evaluated) SPECIMEN SIZE: Greatest dimension: 5 cm SPECIMEN LATERALITY: Left TUMOR SITE: INVASIVE CARCINOMA: Not specified TUMOR SIZE: SIZE OF LARGEST INVASIVE CARCINOMA: Greatest dimension of largest focus of invasion over 0.1 cm: 2.1 cm TUMOR FOCALITY: Single focus of invasive carcinoma MACROSCOPIC AND MICROSCOPIC EXTENT OF TUMOR: Skin: Skin is not present DUCTAL CARCINOMA IN SITU (DCIS): DCIS is present (THE CARCINOMA IN SITU IS MIXED, DUCTAL AND LOBULAR) Extensive intraductal component (EIC) negative. NUCLEAR GRADE: Grade II (intermediate) NECROSIS: Present, focal (small foci or single cell necrosis) LOBULAR CARCINOMA IN SITU (LCIS): Present HISTOLOGIC TYPE OF INVASIVE CARCINOMA: Invasive carcinoma with ductal and lobular features ("mixed type carcinoma") GLANDULAR (ACINAR)/TUBULAR DIFFERENTIATION:S Page 2 of 6 Print Date/Time:
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+--- Page 3 ---
+MRN: Patient: Sex/DOB: Female Surgical Pathology Report Collected Date/Time: Accession Number: Received Date/Time: Score 3: <10% of tumor area forming glandular/tubular structures NUCLEAR PLEOMORPHISM: Score 3: Vesicular nuclei, often with prominent nucleoli, exhibiting marked variation in size and shape, occasionally with very large and bizarre forms MITOTIC COUNT: Score 1 Number of mitoses per 10 high-power fields: 4. Diameter of microscope field: 0.55 mm OVERALL GRADE: Grade 2: scores of 6 or 7 MARGINS: Margins uninvolved by invasive carcinoma Distance from closest margin: MEDIAL 0.5 mm Distance from superior margin: >2 mm Distance from inferior margin: >2 mm Distance from anterior margin: >2 mm Distance from posterior margin: 1 mm Distance from medial margin: 0.5 mm Distance from lateral margin: >2 mm Margins uninvolved by DCIS (if present) (THE IN SITU CARCINOMA IS MIXED, DUCTAL AND LOBULAR) Distance from closest margin: posterior 1.8 mm. Distance from superior margin: >2 mm Distance from inferior margin: >2 mm Distance from anterior margin: >2 mm Distance from posterior margin: 1.8 mm Distance from medial margin: >2 mm Distance from lateral margin: >2 mm TREATMENT EFFECT: RESPONSE TO PRESURGICAL THERAPY: IN THE BREAST: No known presurgical therapy TREATMENT EFFECT: RESPONSE TO PRESURGICAL THERAPY: IN THE LYMPH NODES:S No known presurgical therapy LYMPH-VASCULAR INVASION: Present DERMAL LYMPH-VASCULAR INVASION: No skin present LYMPH NODES: Number of sentinel lymph nodes examined: 3. Total number of lymph nodes examined (sentinel and nonsentinel): 3. Number of lymph nodes with macrometastases (>0.2 cm): 1 Number of lymph nodes with micrometastases (>0.2 mm to 0.2 cm and/or >200 cells): 0 Number of lymph nodes with isolated tumor cells (less than or equal to 0.2 mm and less than or equal to 200 cells): 0 EXTRANODAL EXTENSION: Present(focal) METHOD OF EVALUATION OF SENTINAL LYMPH NODES: H&E, multiple levels Immunohistochemistry Page 3 of 6 Print Date/Timc
+
+--- Page 4 ---
+MRN: Patient: Sex/DOB: Female Surgical Pathology Report Collected Date/Time: Accession Number: Received Date/Time: PRIMARY TUMOR (INVASIVE CARCINOMA (pT): pT2: Tumor >20 mm but less than or equal to 50 mm in greatest dimension REGIONAL LYMPH NODES (pN): pN1a: Metastases in 1 to 3 axillary Iymph nodes. at least 1 metastasis greater than 2.0 mm DISTANT METASTASIS (M): Not applicable ESTROGEN RECEPTOR: Performed on this specimen Immunoreactive tumor cells present (greater than or equal to I%) Quantitation: 90% PROGESTERONE RECEPTOR: Performed on this specimen Immunoreactive tumor cells present (greater than or equal to 1%) Quantitation: 80% HER2/NEU IMMUNOPEROXIDASE STUDIES: Performed on this specimen Negative (Score 0) FLUORESCENCE IN SITU HYBRIDIZATION (FISH) FOR HER2/NEU: Not performed MICROCALCIFICATIONS: Present in invasive carcinoma Source of Specimen A Lymph Nodes, Sentinel Left B LT Lumpectomy Clinical Information Palpable mass upper outer quadrant, FNAB positive for lumpectomy and sentinel node biopsy PRE-OP DIAGNOSIS: Left breast cancer POST-OP DIAGNOSIS: Same TYPE OF PROCEDURE: Left lumpectomy and sentinel node biopsy Gross Description Specimens received in 2 parts: A.The specimen is labeled "LEFT SENTINEL NODES" and is received unfixed. It consists of 3 lymph node measuring 0.5 x 0.5 x 0.5-2.2 x 1.5 x 1 cm. Sectioned and entirely submitted as follows: A1 =- bisection of a single lymph node A2 = single lymph node A3-A5 =- entire sections of single lymph node Time specimen was removed from the patient: Time specimen was placed in formalin. Ischemic time: 15 minutes Page 4 of 6 Print Date/Time:
+
+--- Page 5 ---
+MRN: Patient: Sex/DOB:  Female Surgical Pathology Report Collected Date/Time: Accession Number: Received Date/Time: B. The specimen is labeled "LEFT LUMPECrOMy" is received unfixed. (Specimen is in formalin more than 6 hours and less then 48 hours). It consists of an ovoid piece of yellow-tan fatty tissue with 3 sutures designate 1 silk anterior, 2 silk medial margin and 3 silk posterior margin. Specimen measuring 5 x 4 x 4 cm. The specimen is oriented and inked as follow: Anterior-yellow, posterior- black, superior-orange, inferior-red, medial-blue, and lateral margin with green color. On sectioning cut surface shows 1.5 x I x 1 cm  and irregular ill-defined mass without any area of hemorrhage or necrosis. This mass is 0.5 cm from anterior, 0.3 cm from posterior, 1.0 cm from superior, 1.2 cm from inferior, 1.0 cm from medial and 2.0 cm from the lateral margin of resection. Representative sections are submitted as follows: B1-B7 = mass with closest anterior, posterior, superior, and inferior margin. B8-B9 = representative sections medial margin B10 =- representative sections lateral margin Time specimen was removed from the patient: Time specimen was placed in formalin : Ischemic time: 30 minutes Dictated Special Stains / Slides IMMUNOHISTOCHEMICAL EVALUATION OF ESTROGEN RECEPTORS, PROGESTERONE RECEPTORS, AND HER-2NEU IN INVASIVE MAMMARY CARCINOMA . ESTROGEN RECEPTORS:90%,POSITIVE PROGESTERONE RECEPTORS: 80 %, POSITIVE. STAINING INTENSITY: MODERATE HER-2NEU: SCORE 0, NEGATIVE. Immunohistochemical studies were performed on formalin fixed paraffin embedded tissue (Block B2) using the following monoclonal antibodies: Estrogen receptor (Clone SP1), Progesterone receptor (Clone 1E2) and Her-2neu. Clone 4B5); control sections for HER-2Neu are provided within a kit (score 0 MCF-7, score 1+ T-47D, score 2+ MDA-MB-453, score 3+ BT-474). Detection system used: polymer. Primary antibodies, reagents and control sections for HER-2neu are all provided by. All controls show appropriate reactivity. Reactivity of Estrogen and Progesterone receptors is determined based on the percentage of positively stained nuclei of tumor cells. Reference values (CAP accreditation program checklist 2010 and guidelines on webpage):. Positive: nuclear staining in 1% or greater than 1% of invasive carcinoma cells Negative : nuclear staining in less than 1% of invasive carcinoma cells. Staining intensity: is reported as weak, moderate or strong.. HER-2neu reactivity is reported applying the CAP scoring guidelines (CAP accreditation program checklist 2010 and guidelines on webpage): Score 0 = Negative: No immunoreactivity, or faint weak immunoreactivity in <10% of tumor cells but only a portion of the membrane is positive.. Page 5 of 6 Print Date/Time:
+
+--- Page 6 ---
+MRN: Sex/DOB:  Female Patient: Surgical Pathology Report. Collected Date/Time: Accession Number: Received Date/Time: Score 1 = Negative: Faint weak immunoreactivity in 10% or >10% of tumor cells but only a portion of the membrane is positive. Score 2+ = Equivocal: Weak to moderate complete membrane immunoreactivity in >10% of tumor cells or circumferential intense membrane staining in <30% of cells. Score 3+ = Positive: More than 30% of the tumor cells must show circumferential intense and uniform membrane staining. A homogeneous (chicken wire) pattern should be present. In the evaluation of the score the pathologist is assisted by the computerized Equivocal results for HER-2neu (Score 2+) will be subsequently followed by a reflex dual-color ISH testing.. Immunohistochemical studies were performed on formalin fixed, paraffin-embedded tissue (Block B6, B8) with adequate positive and negative control sections. The invasive carcinoma shows scattered positivity for E-cadherin. The results support the above interpretation.. Also the results of a P63 stain support hte above findings. Then f hese antibodies were determined by the.  hey have not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such. clearance or approval is not necessary. I nese tests are used for clinical purposes. They should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA-88) as qualified to perform high-complexity clinical laboratory testing. The perfnrmance characteristics of these antibodies were determined by the . They have not been cleared or approvea by tne U.S. rood and Drug Administration. The FDA has determined that such. val is not necessary.  I nese tests are used for clinical purposes. . They should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA-88) as qualified to perform high-complexity clinical laboratory testing. Tissue Code Ptr tSS. QfHer Fur+ner i1/20/13 &+mire this revi ew thy case be lbular larcinoma. Arm nas A new dx siscrepan0y t svppor+ +nis been sjbmit+ed Changl. boe Pew Tss paitholozic dliignosHc Hu Tc6A humr dis eripuncy j Aorm, carciioma Bg i5 dictl lw 71013 Dual/s UA!E 3913 Page 6 of 6 Print Date/Time:
+
+--- Page 7 ---
+TCGA Pathologic Diagnosis Discrepancy Form 4.05  dy Subject Person ID: N/A Study/Site: TCGA Breast Invasive Carcinoma- Age: N/A Event: PathDiscrepancy Date of Birth: Interviewer: Sex: Tumor Identifier Provided on Initial Case Quality Control.  Provide the tumor identifier documented on the initial case quality control form for Form this case. Pathologic Diagnosis Provided Invasive mixed ductal  Provide the diagnosis/ histologic subtype(s) documented on the initial pathology report for on Initial Pathology Report and lobular carcinoma this case. If the histology for this case is mixed, provide all listed subtypes.. Histologic features of the sample provided for TcGA, as.  Lobular  Provide the histologic features selected on the TCGA Case Quality Control reflected on the CQCF Carcinoma Form completed for this case. Discrepancy between Pathology Report and Case Quality Control Forme Provide the reason for the Sample sent to TCGA was stained by IHC for E- Provide a reason describing why the diagnosis on the initial discrepancy between the pathology  cadherin, the pattern of reactivity was absent to very pathology report for this case is not consistent with the report and the TCGA Case Quality incompletely weak, consistent with a lobular diagnosis selected on the TCGA Case Quality Control Form. Control Form phenotype.  Name of Tss Reviewing Pathologist or Biorepository  Provide the name of the pathologist who reviewed this case for Director TCGA.
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diff --git a/output/text/bc9e9ad5-1680-4559-99d4-e4c46eca61f1.txt b/output/text/bc9e9ad5-1680-4559-99d4-e4c46eca61f1.txt
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index 0000000000000000000000000000000000000000..c87abd1e8631280f125b7fa5add20c1ad3fc4442
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+UUID:0779E478-5351-4169-9F9F-D51D77EA108D TCGA-CV-A460-01A-PR Redacted DOB: Sex: M Physician: Received: Pathologist Accession: Case type: Surgical History ** Case imported from legacy computer system. The format of this report does not match the original case. ** ** For cases prior to , the section "SPECIMEN" may have been added. ** DIAGNOSIS (A) LYMPH NODE, LEFT EXTERNAL JUGULAR, EXCISION: Two lymph nodes, no tumor present.. (B)) LARYNX, TOTAL LARYNGECTOMY, PARTIAL PHARYNGECTOMY AND BILATERAL NECK DISSECTION WITH SUBTOTAL THYROIDECTOMY: INVASIVE POORLY DIFFERENTIATED SQUAMOUS CELL CARCINOMA OF THE RIGHT PYRIFORM SINUS. SURGICAL MARGINS ARE FREE OF TUMOR. Submental lymph node, 1 lymph node, no tumor present. Right Level'I, 4 lymph nodes, no tumor present (0/4). Right 1eve1 II, METASTATIC SQUAMOUS CELL' CARCINOMA IN 3 OF 3 LYMPH  NODES WITH EXTRACAPSULAR EXTENSION (3/3). Right Level 1I1, 9' Tymph nodes, no tumor present (0/9). Right LeVe1 IV, METASTATIC SQUAMOUS CELL CARCINOMA IN 1 OF 22 LYMPH NODES wITH EXTRACAPSULAR EXTEnSION (1/22). Left Leve] Iv,'20 1ymph nodes,'no tumor present*(0/20). Left 1evel v,'4 1ymph nodes, no tumor present (o/4). Salivary gland, unremarkable.. Thyroid' gTand, ' unremarkable. (c) Teeth,' extraction: 1cs.0 -3 For gross examination only. Carciomt, sqiusmos clL, No5 8o7013 c32.9 h Entire report and diaqnosis romnleted bv: Report released by: GROSS DESCRIPTION (A)**LEFT EXTeRNAL JUgULAR LYMPH NODE -.Fibroadipose tissue, 3.0.x 2.0 x 1.0 cm' containing two lymph nodes, 1.5 and 1.0 cm in greatest dimension. 1arger 1ymph node exhibits near that complete fat replacement. The 1ymph node contains a dark tan/red nodule. Entirely submitted for frozen  The smaller section examination. 'SEction coDe:  Al-A2, frozen section examination. (B) TOTAL LARYNGECTOMY, PARTIAL PHARYNGECTOMY AND BILATERAL NECK DISSECTION AND susToTAL THyroIDecromy - A total laryngectomy and bilatera! neck dissection of thyroidectomy, (9.0 x 9.0 x'4.0 cm). "Multipie en1arged 1ymph x 1.0 cm ulcerated and contracted mass is noted'in the right pyriform sinus. Tumor does not encroach on the right side of the larynx and is' confined to the right pyriform area.  No other noticeable lesion is noted in the right or left transglottic or subglottic areas. Tumor submitted sequentially.. SectIon coDe:  B1-s13, mucosal margins of resection; B14-s21, sequential Page 1 of 2  History Case Pathology Report History Case Pathology File under: Pathology
+
+--- Page 2 ---
+DOB: Sex: M Physician: Received: Pathologist: Accession: Case type: Surgical History sectioning of the tumor from right to left; b22, right transglottic mucosa; 823, b24,"left transglottic mucosa; B25, representatjve sections of thyroid; B26, submenta1 1ymph node; s27, level I, right, one 1ymph node bisected; s28 1evel"I, right, one 1ymph' node' bisected, s29, 1evel I, right, one lymph node bisected; b30,'level I, right,  one lymph node bisected; b31,' 'level f, right, submandibular'gland; s32, Tevel 11, right, grossly involved'lymph node representative section; s33, level'II,~right, one lymph node bisected; s34, 1evel Irr, right, multiple. 1ymph nodes;~s38, leve1 Iy,, right, grossly involved lymph node, representative section; s39,"level rv, right, one Tymph node bisected;' b40, level' Iv, right, level II. B45, level IIr, left, four lymph nodes; B47, level III, 1ymph'node bisected; B49, level IIr,' left, three lymph nodes; B50, level III, left, two lymph nodes; b51, level III,. 1eft, four 1ymph nodes; B52, level Iy,. 1eft, multip1e 1ymph nodes, b53, level Iv," 1eft, two Tymph nodes; 854, 1eve1. 1evel Iv, 1eft, mu1tip1e 1ymph' nodes; 359, 1eve1 v,'left, three 1ymph'nodes; B60,' level 'v, 1eft, two 1ymph nodes,' b61,' level'v, ' Teft,' one' 1ymph"node trisected. *FS/DX: CIRCUMFERENTIAL MUCOSAL MARGINS, NO TUMOR PRESENT. (c)  Teeth'-- Three teeth'with muitiple fragments of dental material.  One tooth has a silver-colored crown.  No sections obtained. SNOMED CODES M-80703 M-80706 r-24100 T-B6000 T-C4200 Page 2 of 2 History Case Pathology Report History Case Pathology. File under: Pathology
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diff --git a/output/text/bcbbc268-65eb-4291-8f40-f6fc5d18f78d.txt b/output/text/bcbbc268-65eb-4291-8f40-f6fc5d18f78d.txt
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index 0000000000000000000000000000000000000000..ada1034186be382c213461c3d3edfadc5ad4cbdb
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+--- Page 1 ---
+UUID:5A44048E-8478-413C-8C37-2FD45947AC3A TCGA-UZ-A9PQ-01A-PR Redacted SURGICAL PATHOLOGY REPORT Patient Name Accesslon #: Med. Rec.#: Visit #: Service Date: DOB: Sex: Male Received: Soc. Sec. #: Location: Ctient: Physician(s): FIinal Pathologic Diagnosis A. Kidney, right, nephrectomy: Papillary renal cell carcinoma (9.2 cm), Fuhrman grade 3; see comment. B. "Retrocaval Iymph node," excision: 1. Papillary renal cell carcinoma (5.8 cm), apparently replacing a lymph node. 2. Adrenal gland with no significant pathologic abnormality, no tumor present. T0D-0:3 Comment: agenonia ysapellasey sinss Kidney Tumor Synoptic Comment ceQl 8QcD|3 -Histologic type: Renal cell carcinoma, papillary.. -Grade: Fuhrman grade 3. Sut : Keolrey NOS Co4.9 -Maximum tumor diameter: 9.2 cm. -Site within kidney: Mid kidney. -Renal pelvis: Normal. Q3/3|14 -Ureter: Normal. -Renal sinus: Tumor invades renal sinus.. -Hilar renal veins: Normal, no tumor. -Intrarenal veins and lymphatics: Normal, no tumor.. -Adrenal gland: Normal. -Capsule/perirenal fat: Tumor does not penetrate capsule. -Hilar lymph nodes (number positive/number of nodes): 0/0. We searched for hilar lymph nodes, but none were identified. -Resection margins: Negative. -Proximity to nearest margin: 0.25 cm from the renal capsule and overlying perirenal adipose tissue. -Stage: pT2N1Mx. -Additional comments: The kidney tumor demonstrates a papillary architecture throughout, with presence of foam cells focally. Papillary renal cell carcinomas are divided into grades I and 2 based on morphologic features. This tumor contains some features of type l, including cuboidal cells with small nuclei and presence of foam cells. Other areas demonstrate type 2 features, with abundant eosinophilic cytoplasm, Page 1 of 3
+
+--- Page 2 ---
+stratification, and larger nuclei. Overall, this tumor would be classified as a more aggressive papillary renal cell carcinoma type 2. A few foci with clear cells are present. A recent study showed that papillary renal cell carcinomas which showed extensive clear cell change (>75%) had cytogenetic abnormalities that were ry? characteristic of conventional clear cell carcinomas rather than papillary renal cell carcinomas. However, 20 the significance of the presence of few clear cell foci is not known, and this tumor is viewed as a papillary renal cell carcinoma. Papillary renal cell carcinomas have a better 5- and 10- year survival rate at 86% and 82% than that of conventional renal cell carcinomas at 77% and 70%. Besides the main tumor mass, multiple other satellite tumor nodules were present that measured 1.0 cm in aggregate. Multifocality is a prominent feature of papillary renal cell carcinomas. The hilar region was carefully examined to look for the presence of lymph nodes, but none were identified.. Part B (retrocaval lymph nodes) contains a well-circumscribed tumor mass, measuring 5.8 cm. In the. periphery, a small amount of lymphoid tissue is present, consistent with lymph node metastasis with almost entire replacement of the lymph node. Also adjacent to this tumor mass, the adrenal gland is identified, which shows no gross or microscopic evidence of tumor involvement. In the peri-adrenal adipose tissue, a small nodule was present which was a potential lymph node, but morphologic examination revealed a sympathetic ganglion. Speclmen(s) Received A:Right kidney 8:Retrocaval lymph nodes. Clinicat History The patient is a ar-old man with a right kidney tumor. He undergoes nephrectomy.. Gross Description The specimen is received fresh in two parts, each labeled with the patient's name and medical record number. Part A is additionally labeled "right kidney." It consists of a kidney with attached perirenal fat, weighing 861 gm and measuring 16.0 x 14.0 x 9.5 cm. Bivalving reveals a 10.0 x 8.5 x 7.5 cm kidney. The mid-kidney is largely occupied by a tumor, measuring 9.2 x 8.0 x 8.0 cm, with some peripheral uninvolved kidney. The tumor is well circumscribed, the cut surface is heterogeneous and tan-white to yellow, with some gelatinous areas. The tumor abuts the capsule but does not invade it at any point. It appears to involve the renal sinus, and compresses the structures present there, but does not invade into a vessel. Also present within the kidney, separate from the main tumor mass, are multiple small tumor nodules, measuring 1.0 x 1.0 cm in aggregate. In the unaffected kidney, the cortex measures 0.8 cm, and the medulla measures 1.8 cm. The ureter, renal artery, and renal vessel resection margins are clear and uninvolved by tumor. Sectioning of the perirenal and hilar adipose tissue reveals no tumor or lymph nodes. No adrenal gland is identified. Sections are submitted as follows: Cassette Al: Resection margins of renal artery, vein, and ureter.. Cassette A2: Tumor with closest proximity to capsule. Cassettes A3-A6: Representative tumor. Cassette A7: Tumor nodules away from the main tumor mass.. Cassette A8: Tumor with adjacent uninvolved kidney.. Cassette A9: Uninvolved kidney. Cassette A10: Representative perirenal adipose tissue. Part B is additionally labeled "retrocaval lymph nodes." It consists of an unoriented fragment of yellow-tan fibroadipose tissue, measuring 10.5 x 5.5 x 3.0 cm. The external surface is inked in black. Serial sectioning reveals a well-circumscribed tumor nodule, measuring 5.8 x 4.2 x 3.2 cm, which is apparently encapsulated; it has a tan-yellow cut surface and grossly is almost identical to the primary renal tumor. No definite peripheral lymph node tissue is identified. Adjacent to this tumor nodule but apparently separated from it, the adrenal gland is identified, measuring 7.0 x 2.0 x 0.3 cm. Serial sectioning of the adrenal gland demonstrates a yellow-black, speckled cut surface. No discrete lesions or involvement by tumor is identified. Sectioning of the attached adipose tissue reveals one possible lymph node. Sections are submitted as follows: Page 2 of 3
+
+--- Page 3 ---
+Cassettes B1-B2: Tumor mass. Cassettes B3-B4: Representative cross sections of adrenal gland. Cassette B5: Possible peri-adrenal lymph node. Diagnosis based on gross and microscopic examinations. Final diagnosis made by attending pathologist following review of all pathology slides.. athology Resident. hologist Electronically signed out on DISQUALIFIE eviewed17g4 ao13 Page 3 of 3
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+
+--- Page 1 ---
+RUN DATE PAGE 1 RUN TIME RUN USER PATIENT ACCT #: AGE/SX : ROOM : REG DR DOB: BED: STATUS : SPEC # RECD : STATUS: COLL : TIME IN FORMALIN: 6:29 nrs. COLD ISCHEMA TIME: 0:00 mins. CLINICAL INFORMATION: Pre-Op Diagnosis: Right breast mass Remarks: Specimen(s): A. Right breast mass B. IDO3 Right breast sentinel node C. Posterior medial margin D. Medial margin J 8sDeA3 Sub B Yustnos 150.4 MICROSCOPIC DIAGNOSIS X 6/14/13 A BREAST. RIGHT (REGION NOT OTHERWISE STATED). LUMPECTOMY: INVASIVE GRADE 3 DUCTAL CARCINOMA MEASURING 3.5 CM IN GREATEST DIMENSIONS ASSOCIATED HIGH-GRADE DUCTAL CARCINOMA IN SITU (DCIS) WITH CANCERIZATION OF THE LOBULES AND COMEDO NECROSIS: NOT EXTENSIVE NO ANGIOLYMPHATIC INVASION IDENTIFIED TUMOR FOCALLY INVOLVES INKED DEEP MARGIN ADJACENT TO SKELETAL MUSCLE TISSUE (NOT IN SKELETAL MUSCLE) HEALING WOUND REACTION CONSISTENT WITH PREVIOUS CORE NEEDLE BIOPSYS B. SENTINEL LYMPH NODE. RIGHT AXILLA. EXCISION: ONE (1) LYMPH NODE NEGATIVE FOR METASTATIC CARCINOMA BY ROUTINE LIGHT MICROSCOPY AND CYTOKERATIN (PANK+) IMMUNOSTAIN C. ADDITIONAL RIGHT BREAST LUMPECTOMY POSTERIOR MEDIAL MARGIN:S ADIPOSE AND SKELETAL. MUSCLE TISSUE. NEGATIVE FOR CARCINOMA D. RIGHT BREAST LUMPECTOMY MEDIAL MARGIN: FIBROADIPOSE BREAST TISSUE AND SKELETAL MUSCLE TISSUE. NEGATIVE FOR CARCINOMA COMMENT(S) The large mass is a poorly differentiated ductal carcinoma. Microscopically. the tumor does focally extend to the inked deep margin which is adjacent to the skeletal muscle tissue on the medial half.  The additional margin tissue submitted for ovaluation is. negative for carcinoma and. assuming that this tissue was obtained from the region of the positive margin on the original specimen, would provide an additional o.8 cm to 1 cm margin. Protocol for the Examination of Specimens From Patients With Invasive Carcinoma of the ** CONTINUED ON NEXT PAGE ** UUID:B18B184D-B7F1-4C4D-8DA2-D5ECF49749F6 TCGA-LL-A6FR-01A-PR Redacted
+
+--- Page 2 ---
+PAGE 2 RUN DATE: RUN TIME: RUN USER: (Continued) SPEC #: PATIENT: COmmENT(S) (Continued) Breast . Based on AJCC/UICC TNM. 7th edition Excision without wire-guided localization Procedure: Lymph Node Sampling: Sentinel lymph node Specimen Laterality: Right Histologic Type: Invasive ductal carcinoma (Nos) Greatest dimension: 3.5 cm Tumor Size: Histologic Grade (Nottingham): Glandular Differentiation: Score 2 Nuclear Pleomorphism: Score 3 Mitotic Rate: Score 3 Overall Grade: Grade 3. Tumor Focality: Single focus of invasive carcinoma Ductal Carcinoma In Situ: 7DcIs is present Margins uninvolved by invasive carcinoma (see Margins: comment above) DcIs: Margins uninvolved by DcIs Lymph Nodes: Number of sentinel lymph nodes examined: 1 Total number of lymph nodes examined (sentinel and nonsentinel): 1 Number of lymph nodes without tumor cells identified: 1 Primary Tumor: pT2 Pathologic Staging Regional Lymph Nodes: Modifier: sn Category: pNo(i-) Distant Metastasis: Not applicable Ancillary Studies: ER: Negative PR: Positive (3% tumor cells with weak staining intensity) HER2 Immunoperoxidase Studies: Equivocal (Score 2+) In Situ Hybridization: Amplified Average Number HER2 Gene Copies Per Cell: 5.4 Average Number of Chromosome 17 Per Cell: 2.0 GROSS DESCRIPTION:  Received fresh for gross evaluation of margins and selection of tissue for tissue bank. is a lumpectomy specimen which weighs 51 grams and measures 6.5 x 6.5 x 3 cm. There is a. 3.5 x 1 cm ellipse of dark brown skin. There is a 2.5 x 2.5 cm portion of skeletal muscle on ths undersurface. On palpation. a mass is appreciated. Two sutures orient the specimen Dr. also placed a smaller as follows: lateral long stitch and superior short stitch. stitch which represents closure of a flap of tissue representing additional tissue at. the superior aspect. The specimen is inked as follows: superio-anterior blue, inferio-. anterior black. lateral yellow. medial red. and deep green. The specimen is placed into Bouin's solution. The specimen is serially sectioned revealing a retracted yellowish white tumor which measures 3.5 x 2.2 x 1.7 cm. Core needle biopsy tracts are within the mid. portion of the tumor..  The closest margin is the inked deep margin where the tumor abuts ** CONTINUED ON NEXT PAGE **
+
+--- Page 3 ---
+PAGE 3 RUN DATE: RUN TIME: RUN USER: PATIENT: (Continued) SPEC #: GROSS DESCRIPTION: (Continued) this margin in the medial half. A portion of the tumor is provided to the tissue banking The results of the margin status were given to Dr.. in the operating coordinator. room at Cassette Summary: 1 perpendicular sections of medial margin 2 perpendicular sections of lateral margin. 3,4 closest deep margin 5.6 a full cross-section of tumor. superficial and deep 7.8 full cross-section of tumor. 9 section of tumor in vicinity of muscle 10 additional section B. Received fresh for gross intraoperative ovaluation labeled with the patient's name and "right breast sentinel node" is a 4 x 2 x 1 cm ovoid portion of fatty tissue. Sectioning reveals a single 3 x 1.5 x 1 cm partially blue dye-stained tan lymph node. The lymph node is serially sectioned perpendicular to the long axis. No gross obvious. carcinoma. The results are relayed to Dr.. in the operating room. The specimen is. totally submitted in blocks B1 through B4 for sentinel lymph node protocol.. C. Received fresh labeled with the patient's name and "right breast lumpsctomy posterior medial margin" is an additional <2 gram portion of fibroadipose tissue measuring 3 x 1.5 x 0.8 cm. Muscle is present on one end. A long stitch marks the medial side away from the tumor. Short stitch is superior. Blue ink is applied to the new posterior deep margin The specimen is serially sectioned with the superior half submitted in block c1 and the inferior half in block C2. D.  Received fresh labeled with the patient's name and "right breast lumpectomy medial margin" is an additional <2 gram. 3 x 1.5 x 1 cm portion of fibroadipose tissue. A long stitch marks the medial side away from the tumor and the short stitch marks superior. Black ink is applied to the new medial margin. The specimen is serially sectioned and submitted in blocks D1 and D2 with the superior half in block D1 and the infsrior half in block D2. INTRAOPERATIVE CONSULTATION: A. RIGHT BREAST: CLOSEST MARGIN DEEP, MEDIAL ASPECT. WITH TISSUE PROVIDED TO TISSUE BANKS COORDINATOR RESULTS DISCUSSED WITH DR. IN THE OPERATING ROOM B. SENTINEL LYMPH NODE: ONE LYMPH NODE WITH NO GROSS TUMOR IDENTIFIEDS RESULTS DISCUSSED WITH DR IN THE OPERATING ROOM ** CONTINUED ON NEXT PAGE **
+
+--- Page 4 ---
+RUN DATE: PAGE 4 RUN TIME: RUN USER SPEC #: (Continued) PATIENT PHOTO IOCUJMENTATION Image Signed (signature on file)_ ** END OF REPORT ** W 3013 agac'i Dicrep tmary mor Site
\ No newline at end of file
diff --git a/output/text/bcc2c9aa-044e-47f5-82d3-a336ea9f2195.txt b/output/text/bcc2c9aa-044e-47f5-82d3-a336ea9f2195.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ec3c60c11385224869c12d94459f788a29b6d8cd
--- /dev/null
+++ b/output/text/bcc2c9aa-044e-47f5-82d3-a336ea9f2195.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+UUID:F4DE97A1-D58D-431F-8C93-8F0647F2F493 Redacted TCGA-GR-A4D9-01A-PR Department of Pathology and Microbiology Name: Accession No: Hosp No: Acct No: Date Taken; DOB: Ago: Date Received: Sex: SSN: Submitted by: Loc: Room: Client: Surgical Pathology FinaI Diagnosis: - -: LBFT NECK LYMPH NODE, EXCISION: LYMPH NODE WITH DIFFUSE LARGE B-CELI LYMPHOMA, NONCLBAVED (SBB COMMENT). (B-DLCL-NC) Diagnosis Comment: The lymphoma is immunophenotypically consistent with non-GCB type. icD O3 l ymPhoma,difuse, large B-cri, nos Signed: 968oj3 Sik=lqm?hir0k,cervica! C77,O 9-201z Rd Flow Cytometry Date Ordered: Status: Date Reported Interpretation Lymph Node Left Neck: A population of mature B-cells with increased forward and side light soatter expressing CD19, CD20, partial CD25, high-density CD38 and monotypic, intermediate density lambda Jight chains is present at 43% of lymphocytes (25% of isolated cells). This phenotype is consistent with a. B-cell lynphoproliferative disorder and suggests an intermodiate to high-grade process. Correlation with morphologic studies is required for definitive classification. ** Note: For additional testing detalls see Flow Cytometry Report. Thase materials wery Dlo staffpathologist 1 of3
+
+--- Page 2 ---
+P.003 3cx:F Accession No: D.O.B. Namo: Date Take Hosp No: Submitted bya Surgical Pathology History: yoar-old female with atypical lymphocytes noted on fine needlo aspiration of neck mass, The patient is a and comtmon variable immunodeficlency. Source/Gross: and designated "left lymph neck nodo for. Received fresh in a container labeled '. lymphoma studios" is a tan-pink lymph node oandidate (2.2 x 2.1 x 1.3 cm). The lymph node candidate is triaged for Lymphoma Study Protocol after consultation with Dr. Lymphoma Study protocol: I piece for flow cytometry 2 touch imprints 1 piece for cytogenetic studies 1 piece frozen in OCT for immunohistochemistry 1 piece frozen in foil for molecular biology. A1 B-plus fixation A2-5 24-nour formalin fixation 2 of 3
+
+--- Page 3 ---
+P.004 Nante: D.O.B. ex: Accession No: Subanitted by Date Take Hosp No: Surgical Pathology Microscopic: IMMUNOPEROXIDASE REPORT PARAFFIN TISSUE - (Done a B-Cell Markers T-Cell Markers Other Markers CD20(L26) CD45RO(UCHL1) ND CD45(LCA) ND CD79a ND CD43(L60) ND CD30(Ber-H2) ND CD10 CD3: CD15(Lcu M1) ND CD5 BCL-2 BCL-6 EBERs MUM1 + INTERPRBTATION: The paraffin markers indicate a B-coll phenotype, consistent with non-GCB subtype.. RNA control for in sits is accentahl. Th. BBy study was devoloped and its performance characteristics determined by The Immunoperoxidase Laboratory. It has not been cleared or. approved by tho U.S. Food and Drug Admnustration. The FDA has determined that such clearance or approval is not necessary. This test is used for clinical purposes. It should not be regarded as investigational. ox for rescarch. This laboratory is certified undor the Clinical Laboratory Improvement Amendmonts (CLIA) as qualified to perform bigh complexity clinical laboratory testing.. Participating Fellow: 3 0f 3
+
+--- Page 4 ---
+P.005 Department of Pathology and Microbiology. Name: Accesston No: Hosp No: Acot No: Date Taken: DOB: Age: Date Received: Sox: SSN: Suomitted by! Loct Room: Cllent: Flow Cytometry Interpretation : Lymph.Nods Left Neok: A population of mature B-oslls with inoroased forward and side light scattex expressing CD19, CD20, partial CD25, high-density CD38 and monotypic, intermediate density lambda light ohains is present at 43% of lymphocytes (25% of isolated cells). This phenotypo is consistent with a "Becell lymphoproliferative-disorder and suggests an intermediate to high-grade process. Correlation with morphologic studies is required for definitive classification. Sre: Sigaed: Procedure:Notes: CLINICAL HISTORY/ SUSPBCTED DIAGNOSIS: Suspicious for lymphoma. Specimen Source; Left Neck Lymph Node. Ficolled: No Viability: 40% % Abnormal cells: Monotypic B-cells at 43% of lymphocytes. The'specinien was analyzed using tho following 23 antibodics: CD45. .CD10 CD11b CD2 CD19 + CD11c CD3 CD20 + CD14 CD4 CD23 CD16 CD5 CD24 CD25 +, pattial Thes matarials were exominet by all those lisisd io estavlish tho diagnosls with the signalurs being the rasponsible stasfpathoiogis! 1 of2
+
+--- Page 5 ---
+P.006 Namo: D.O.B. Sex: Accession No: Submittd by: Date Tak Hosp No: Flow Cytometry CD7 Kappa CD34 CD8 Lambda +, intermediateCD38 +, bright CD56 CD103 Clinical diagnosis and/or therapy should not bo based solely on this assay. The results should be considered in conjunotion with clinical information, morphologio findings, and additional diaenostic tests. This test was developed and its performance characteristics determined by tho. Rlow Cytometry Laboratory. It has not been cleared or apptoved by the US Food and Drug Administration. The FDA has detennined that such clearance or approval is not necessary. This test is used for clinical purposes. It should not be regarded as investigational or for research. This laboratory is oertified under the Clinical Laboratory Improvement Amendments : (CLIA  as qualified to perfom high complexity clinical laboratory testing. 2 of 2
+
+--- Page 6 ---
+P.007 PATIENT INFORMATION NAM. MET DATE SURGICALPAIHOLOO SPECIMEN REQUEST FORM SEX:  Male Femaie APFIX PAMENT LABEL HEREIFAVAILABLE CUNICAL HISTORY, PRE OPERATIVE DIAGNOSIS, POST OPERATIVE DIAONOSIS OR OTHER PERTINENT LABORATORY FINDINGS: SPECIAL REQUEST:.. FROZEN SEMTIONA ye8 ] NO ORDERING PROVIDER .... EXT. I NO. REFERRING PHYSICIAN: OZEN SECTION DATEMME SPECIMEN COLLECTIO SPECIMEN SOURCE: MKtrrt A utt ne lywnc noue PATHOLOGIST SIGNATURE: REPORT TO: TIME RECEIVED: TIME REPORTEO: ISE ONLY CREW CHECKLIST  Patient's ID Check  Site Verificatlon Cabel Verificatlon Form Complete  Nursing Signatura NOT TO Be FiLED IN PERMANEnT MEDICAL RECORDE $URGICAL PATHOLOGY SPECIMEN REQUEST imary Tumor Site Discrepancy HIPAA Discrepancy
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diff --git a/output/text/bcc884eb-a009-4504-b42a-c7fa6e61ecab.txt b/output/text/bcc884eb-a009-4504-b42a-c7fa6e61ecab.txt
new file mode 100644
index 0000000000000000000000000000000000000000..986403940510fab818b3a242150a9ea39bdc1286
--- /dev/null
+++ b/output/text/bcc884eb-a009-4504-b42a-c7fa6e61ecab.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Patient Name: zcD-o 3 Sex: Female 839013  UUID: 83F53610-4F40-4258-9869-B8894234224F Redacted Cs^texC74.D Jtd 1/8o)13 Macroscopy. One vessel containing a material immersed in formaldehyde solution, described as following: product of segmental resection of the left kidney and an adrenal mass, previously sectioned, measuring 13 x 8 x 4 cm. The adrenal mass measures 6 x 5 x 4 cm, weights 38 g and the intemal surface is characterized by an homogeneous light-brown tissue surrounded by a rim of dark yellow tissue. Maeroscopically. no areas of necrosis are evident. Macroscopic invasion of the renal vein is evident. Conclusion: Product of left nephrectomy and adrenal mass resection: Adrenocortical carcinoma with the following features: Largest diameter -- 6 cm. Weight-38 g .Nuclear grade (Fuhrman) -- 3 :Diffuse architectural pattern -- present Clear cells in  25% of the neoplasm - present :Areas on necrosis - present (focally) Mitotic count -- less than 5 in 50 H.P.F. .Atypical mitosis - not detected .Capsular invasion -- not detected Venous invasion -- present Sinusoidal invasion - not detected
+
+--- Page 2 ---
+WEISS SCORE = 5 . Presence of a neoplastic thrombus within the renal vein. Absence of metastasis in four dissected lymph nodes.
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diff --git a/output/text/bce9c7b2-aca2-4559-9f97-96824739b912.txt b/output/text/bce9c7b2-aca2-4559-9f97-96824739b912.txt
new file mode 100644
index 0000000000000000000000000000000000000000..00687b3bdf330e5125f98de3f874685de2d0ec00
--- /dev/null
+++ b/output/text/bce9c7b2-aca2-4559-9f97-96824739b912.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+ICs-0- Procedure Date: Procedure Physician: Chrtioma Attending Physician/Copies To:e Site: Bunot N^0s c50.9 PAtient hIstORy: UUID: 501C3E1B-573B-4A5A-A0ED-3CD15432E6FFE TCGA-BH-A1FH-01A-PR +DATE OF LMP: * Redacted DATE OF LAST DELIVERY: PRE-OF DIAGNOSIS: LEFT BREAST CAS POST-OP DIAGNOSIS: SAME OPERATIVE PROCEDURE: LEFT MOD RAD MASTECTOMYS CLINICAL HISTORY:S MATERIAL SUEMITTED: LEFT (MOD) RADICAL MASTECTOMY, PROCUREMENT BY SURGICAL PROCEDURES FINAL DIAGNOSIS:S T BREAST, MODIFIED RADICAL MASTECTOMY: -~~INFILTRATING DUCT CARCINOMA,>2.5 BY 2.O BY 1.S CM, NUCLEAR AND ARCHITECTURAL GRADE 2S LYMPHOVASCULAR SPACE INVOLVEMENT PRESENT - MARGINS FREE OF LESION - FIBROCYSTIC CHANGES AND REACTIVE CHANGES SUGGESTIVE OF PREVIOUS BIOPSY SITES - EIGHT OUT OE THIRTEEN (8/13) LYMPH NODES WITH METASTATIC CARCINOMA AND EXTRACAPSULAR EXTENSION SUPPLEMENIALREPORT My signature below is attostation that I have reviewed all slides and agree with the findings as noted below. IMMUNOPEROXIDASE IDENTIFICATION OF ESTROGEN AND PROGESTERONE RKCEPTORS IS CARRIED OUT ON SLIDE AS. DISTINCT INTRANUCLEAR STAINING IS IDENTIFIED FOR ESTROGEN RECEPTOR (7O4) BUT NOT FOR PROCESTERONE RECKPTOR. THEREFORE, ESTROGEN RECEPTOR IS INTERPRETED AS POSITIVE AND PROGESTERONE RECEPTOR AS NEGATIVE.S
\ No newline at end of file
diff --git a/output/text/bd1f95de-af79-4da3-9f25-5f560aa90c0b.txt b/output/text/bd1f95de-af79-4da3-9f25-5f560aa90c0b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6aa22f54887d208acdd28ac9c024c36bec95bcc5
--- /dev/null
+++ b/output/text/bd1f95de-af79-4da3-9f25-5f560aa90c0b.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+/cs-0 -3 Carcinomn,mfiHnaHng ductel, NOs 8500f3 PiH Sit: Brast UOQ c50.4 1/19/1 cQcF Sif: BustNos c5o.9 Diagnosis: Invasive ductal breast carcinoma (malignancy grade Il) with concomitant high-grade comedo type DCIS with inclusions also of isolated coarse calcifications (procomponent of tumor. 20%), with confluent manifestations in the tumor nucleus and other DCIS components in the tumor periphery. Narrow medial safety margin, as already macroscopically documented. Also. rich DCIS formations extending to within 0.5 cm of the dorsal resection line.. dye-stained resection margins are free of atypia. Mastopathic base structure.. Tumor classification: pT2 (maximum diameter 2.5 cm) pN0 sn (n=3), MX, R0; G2 (L0, V0). UUID:5664F531-9D45-4302-A455-63E4685ED026 GA-A8-A06Y-01A-PR Redacted
\ No newline at end of file
diff --git a/output/text/bd209f10-ba7c-42c4-9cd7-3bfd817acee3.txt b/output/text/bd209f10-ba7c-42c4-9cd7-3bfd817acee3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f3bc1091abe7cd761ba62ad91f5086b5c39ac8fc
--- /dev/null
+++ b/output/text/bd209f10-ba7c-42c4-9cd7-3bfd817acee3.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+UUID: 0CD23E1B-3FA3-4A43-AE6E-C8E7B51252F8 Name: Path No.: -AAAU-01A-PR Redacted MRN: Date Obtained: D.O.B. (Age: Date Received: Sex: F Physician: Location: SURGICAL PATHOLOGY **See Addendum/Procedure** ICD03 SPECIMEN: 'arunona..iyltstiiay Lobula; 852c/3 A:Lymph node, left axilla sentinel, biopsy. B:Breast, left, modified radical mastectomy DIAGNOSIS(ES): 7J6/13/14 A. Lymph node, left axilla sentinel, biopsy:. Metastatic carcinoma, following carcinoma of breast.. B. Breast, left, modified radical mastectomy:. 1. Carcinoma, invasive lobular, poorly differentiated, multifocal, with extensive lymphatic permeation. and extension into nipple. 2. Lobular neoplasia, multifocal.. 3. Fibrocystic disease, proliferative, with atypia.. 4. Metastatic carcinoma in 3 of 12 axillary lymph nodes.. Date Dictated: CLINICAL INFORMATION: None GROSS DESCRIPTION: The specimen is received in two parts.. Part A is received unfixed in a container labeled with the patient's name and "sentinel node #1". It consists of one piece of well circumscribed gritty tan tissue with attached fat measuring 1.2x1.0x0.6cm. It is bisected and a portion of it is submitted as AFS. The rest is submitted in one cassette labeled A1. Part B is received unfixed in a container labeled with the patient's name and "left breast mastectomy tissue" consists of a left radical modified mastectomy specimen measuring 21x17x3 cm. The skin measures 9.5x5x0.1 cm and has a circumareolar scar which measures 4 cm in length. The nipple is mobile and everted. A firm area is palpable. underneath the scar. The deep (fascial) margin is inked black, the remaining margins are inked yellow. The axillary tissue measures 9x5x1.2 cm. Several lymph nodes are palpable within it. One lymph node has been previously. bisected by the surgeon. The lymph nodes range in size from 2.5 to 0.5 cm. They are dissected, proceeding from the axilla towards the breast. The specimen is serially sectioned at closely spaced intervals. Beneath the previously described scar is an ill-defined white, firm area which measures approximately 3.8x3.1x3 cm; it abuts the skin and is 3 cm from the deep margin. A second ill-defined white, firm area is present in the outer, lower quadrant approximately 1 cm from the central lesion; it measures approximately 2.5x2.3x1.8 cm and is located 0.5 cm from the deep margin and 1 cm from the superficial margin. At its center is a 1 cm firm area with a gelatinous appearance. The rest of the specimen is composed of 40% breast tissue, and 60% yellow fatty tissue. Representative sections are submitted in 40. Page 1 of 4
+
+--- Page 2 ---
+cassettes labeled B1-B40. Legend: B1-B3=nipple B4-B13=white, firm area under scar with superficial/skin margin B14-B15-deep margin under white, firm area below scar B16-B17=white, firm area under scar with superficial margin B18-B20=outer, lower quadrant white, firm area with superficial margin B21-B25=outer, lower quadrant white, firm area with deep margin B26=section from center of outer, lower quadrant white, firm area with small gelatinous area B27=deep margin under white, firm area below scar (additional) B28=inner, upper quadrant with deep margin. B29=inner, upper quadrant with superficial margin B30=inner, lower quadrant with superficial margin. B31=inner, lower quadrant with deep margin. B32=outer, upper quadrant with deep margin B33=outer, upper quadrant with superficial margin. B34=one LN from distal part of axillary tail bisected (level 3) B35=three other LNs from distal part of axillary tail (level 3) B36=one LN (the one previously cut by surgeon) in middle part of axillary tail (level 2) B37-B38=one large LN from middle part of axillary tail (level 2) B39-B40=LNs from proximal part of axillary tail (level 1) INTRAOPERATIVE CONSULTATION: AFS: metastatic carcinoma in lymph node Performed by:  Resident: Interpreted by: Attending:. MICROSCOPIC DESCRIPTION: 1. TYPE OF SPECIMEN: Left modified radical mastectomy II. LOCATION OF THE TUMOR: Lower outer quadrant II. LOCATION OF THE TUMOR: Central II. TYPE OF NEOPLASM:  Carcinoma, invasive lobular - pleomorphic, nuclear grade 3  Lobular neoplasia, type B (pleomorphic) widespread IV. GROSS/MICRO FINAL INVASIVE TUMOR SIZE INTERPRETATION: 1.2 cm in greatest dimension, at least V. BORDERS OF INVASIVE NEOPLASM:  III-defined V. VASCULAR SPACE INVASION: Present in lymphatics VII. CALCIFICATION: Present in benign areas VIII. NIPPLE: Stroma involved by cancer. Lymphatics involved by cancer Ducts involved by cancer Ix. SKIN: Uninvolved by cancer. x. ADJACENT BREAST TISSUE: Cystic disease, proliferative with atypia Page 2 of 4
+
+--- Page 3 ---
+XI. SURGICAL MARGIN:  No carcinoma is identified on surgical margins. XII. AXILLARY LYMPH NODES: TOTAL: 13 LEVELI: 4 LEVEL II: 2 LEVEL III: 6 SENTINEL NODE: 1 XIII. POSITIVE LYMPH NODES: TOTAL: 4 of 13 LEVEL I: 2 of 4 LEVEL II: 1 of 2 LEVEL III:0 of 6 SENTINEL NODE: 1 of 1 DEGREE OF INVOLVEMENT: Extensive replacement EXTRANODAL EXTENSION: Absent XIv. PECTORAL MUSCLE: No pectoral muscle identified ADDITIONAL COMMENTS: Invasive carcinoma appears to arise multifocally. A definite second focus is identified in the lower outer quadrant (B26). Below the nipple, the fibrous scar tissue contains multiple separate foci of invasive Iobular carcinoma. Extensive lymphatic permeation is noted.. This report has been reviewed electronically and signed on Interpreted by:  Attending: Case Resident: The diagnosis was rendered by the attending pathologist.. Receptor Expression Analysis Date Ordered: Status: Signed Out INTERPRETATION Test Performed on: Left breast Specimen part: B Slide#: B26 Results: More than 50% of the invasive carcinoma cell nuclei stain with an immunohistochemical stain utilizing an anti-estrogen receptor antibody. Therefore, this tumor is considered strongly positive for estrogen receptor expression.. More than 50% of the invasive carcinoma cell nuclei stain with an immunohistochemical stain utilizing an. anti-progesterone receptor antibody. Therefore, this tumor is considered strongly positive for progesterone receptor expression.. Her-2/neu expression has been evaluated using the. HercepTest. HercepTest score : 0. No Her-2/neu overexpression is identified in the invasive carcinoma cells..  Page 3 of 4
+
+--- Page 4 ---
+This procedure/addenda has been electronically reviewed and signed on. Interpreted by: Attending: Addendum Date Ordered: Status:Signed Out ADDENDUM Molecular Analysis has been ordered on this case, the blocks and slides have been retrieved from the archival files, the slides and pathology report were re-reviewed for tumor cellularity by the pathologist, and the appropriate block was. selected for testing.. This procedure/addenda has been electronically reviewed and signed on. Interpreted by: Attending: h 12[17/13] Note: Immunochemistry testing performed at was developed and its performance characteristics determined by the These tests were interpreted in conjunction with external positive and internal negative controls, unles FDA. This test is used for clinical purposes only. It should not be regarded as investigational or for research.. s(circle):
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diff --git a/output/text/bd5cc7ae-21c5-4ab6-9305-1876b239377c.txt b/output/text/bd5cc7ae-21c5-4ab6-9305-1876b239377c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b8a099d735f405308173c0da9437393adfd50746
--- /dev/null
+++ b/output/text/bd5cc7ae-21c5-4ab6-9305-1876b239377c.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+ICD-O- chomgehohe type. 83l7|3 SURGICAL PATHOLOGY D%udney N6S C649 Case Number : J 8J4/l3 Diagnosis: A: Renal mass #l, biopsy. - Renal cell carcinoma, chromophobe type, nuclear grade 2 (of 4) B: Kidney, base of tumor #1, biopsy - Benign renal parenchyma, no tumor seen C: Kidney mass #2, partial nephrectomy Histologic tumor type/subtype: Renal cell carcinoma, chromophobe type Sarcomatoid features: Not identified Histologic grade (if applicable): 2 (of 4) Tumor size (greatest dimension): 9 mm Tumor focality: Multifocal, there are 3 separate tumors in this patient. Extent of tumor invasion (if present specify if macroscopic or microscopic) : Capsular invasion/perirenal adipose tissue: Not identified Gerota' s fascia: Not identified Renal sinus: Not present in specimen Major veins (renal vein or segmental branches, Ivc): Not present in specimen Ureter: Not present in specimen Venous (large vessel): Not identified Lymphatic (small vessel): Not identified Histologic assessment of surgical margins: Renal parenchymal margin (partial nephrectomy only): Free of tumor Renal capsular margin (partial nephrectomy only): Free of tumor Paranephric adipose tissue margin (partial nephrectomy only): Free of tumor Adrenal gland: Not present in specimen UUID:F0BF5DE6-7AA1-43CF-9A1B-AE40BFC79379 TCGA-UW-A72L-01A-PR Redacted Lymph nodes: None present in specimen
+
+--- Page 2 ---
+Other significant findings: None AJcc Staging: pT1a pNx This staging information is based on information available at the time of this report, and is subject to change pending clinical review and additional information. D: Renal mass #3, partial nephrectomy. Histologic tumor type/subtype: Renal cell carcinoma, chromophobe type Sarcomatoid features: Not identified Histologic grade (if applicable): 3 (of 4) Tumor size (greatest dimension): 2.7 cm Tumor focality: Multifocal, there are 3 separate tumors in this patient.. Extent of tumor invasion (if present specify if macroscopic or microscopic) : Capsular invasion/perirenal adipose tissue: Not identified Gerota' s fascia: Not identified. Renal sinus: Not present in specimen Major veins (renal vein or segmental branches, Ivc): Not present in specimen Ureter: Not present in specimen Venous (large vessel): Not identified Lymphatic (small vessel): Not identified Histologic assessment of surgical margins: Renal parenchymal margin (partial nephrectomy only): Free of tumor. Renal capsular margin (partial nephrectomy only): Free of tumor Paranephric adipose tissue margin (partial nephrectomy only): Free of tumor Adrenal gland: Not present in specimen. Lymph nodes: None present in specimen
+
+--- Page 3 ---
+Other significant findings: None. AJcc Staging: pT1a pNx This staging information is based on information available at. the time of this report, and is subject to change pending clinical review and additional information.. Clinical History: -year-old female with renal masses. Gross Description:. Received are four formalin-filled containers.. Container A is additionally labeled "renal mass #l." It consists. of a 0.7 x 0.5 x 0.4 cm fragment of pink/tan rubbery tissue that. is inked blue, bisected and submitted in block Al, Container B is additionally labeled "base of tumor #l." It consists of a 0.4 x 0.1 x 0.1 cm fragment of soft pink/tan tissue submitted in block Bl, Container c is additionally labeled "renal mass #2." It consists of a 1 gram (1.6 x 1.2 x 0.9 cm) partial nephrectomy that has a. 0.9 x 0.9 x 0.8 cm well circumscribed smooth tan rubbery nodule.. The nodule abuts the capsule (inked yellow) and is 0.3 cm from the parenchymal margin (inked black). The specimen is sectioned perpendicular to the parenchymal margin and submitted in blocks c1 and c2. Container D is additionally labeled "renal mass #3." It consists of a 17 gram (3.4 x 3.1 x 3.0 cm) partial nephrectomy. Approximately 75% of the cut surface is involved by a 2.7 x 2.7 x 2.5 cm well circumscribed smooth tan rubbery nodule that bulges the capsule (inked yellow) and is 0.5 cm from the parenchymal margin (inked black). A portion of the nodule is. given to. and perpendicular sections. of nodule with capsule is submitted in block Dl, and. perpendicular sections of nodule with parenchymal margin is submitted in blocks D2-D4.. hJ 7/3o/s
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diff --git a/output/text/bd7103ff-19aa-44de-afa9-6eaaab2573c4.txt b/output/text/bd7103ff-19aa-44de-afa9-6eaaab2573c4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..cdb4b66db5bec592308a7f11629e85a9aba0460f
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Case ID
+
+--- Page 2 ---
+Formatted Path Report LARGE INTESTINE TISSUE CHECKLIST Specimen type: Hemicolectomy Specimen size: Not specified Tumor site: Hepatic flexure Tumor size: 7 x 8 x 2 cm. Tumor features: None specified Histologic type: Adenocarcinoma. Histologic grade: Moderately differentiated Tumor extent: Invades other organs (specify) Lymph nodes: 4/4 positive for metastasis (Intraabdominal 4/4) Margins: Not specified. Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: Tumor invades the liver..
+
+--- Page 3 ---
+Date of Laterality Procurement NA
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diff --git a/output/text/bd7e5dfb-943c-44a1-b116-3bf2ab39bbbd.txt b/output/text/bd7e5dfb-943c-44a1-b116-3bf2ab39bbbd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4e6d6e86f5f866bb7e9db8af0fc7cb3d08a7d4dc
--- /dev/null
+++ b/output/text/bd7e5dfb-943c-44a1-b116-3bf2ab39bbbd.txt
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+
+--- Page 1 ---
+I0D 0 :3 Date of surgery : Melsnem, npu relle eell 8772/3 OChoro Left eye enucleation Cw9.3 D 3/1e/14 Macros copy The eyeball measures 25 mm in diameter with a segment of optic nerve of 6 mm. At the section, there is at the postero-lateral part of the eyeball a large pigmented tumor adherent to the internal face of the sclera, measuring 18 mm main line by 12 mm maximum thickness. Samples have been made for cryopreservation . The specimen has been then included entirely after fixation. Microscopy The tumor seen laterally at the posterior part of the eye correspond microscopically to a tumor proliferation of fusiform cells made of medium to large size cells with cytoplasm nearly always loaded with melanin pigment preventing the visualization of the nucleus which is therefore difficult to analyze. This tumor proliferation is adherent to the internal part of the sclera whose internal layers are infiltrated without any extraocular infiltration. In the front, the tumor infiltrates the posterior part of the ciliary body but stays outside the iris, the irido corneal angle and the anterior chamber. Behind, it stays distant from the intraocular emergence of the optic nerve which is free on its entire course ( prelaminar part, optic foramen, post laminar part , meningeal sheaths and posterior cut end.). Conclusion Melanoma with fusiform cells measuring 18 by12 mm main lines.. The tumor infiltrates in front the posterior part of the ciliary body.Behind, the proliferation stays distant from the intraocular emergence of the optic nerve which is free on its entire course ( prelaminar part, optic foramen, post laminar part , meningeal sheaths and posterior cut end.) The tumor proliferation infiltrates the internal layers of the sclera but no extra sclera extension was found. UUID:9495F79F-3227-454F-942C-05CEC7827385 TCGA-V4-A9EK-01A-PR Redacted fw i3|3af13
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diff --git a/output/text/bd9d68d5-a178-49be-a016-6581c90b0fb9.txt b/output/text/bd9d68d5-a178-49be-a016-6581c90b0fb9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..87aaa2162a0a5a47f4b3dfd6b8bec4ec2b1519d2
--- /dev/null
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+
+--- Page 1 ---
+page 1 / 1 Department of Cancer Pathology. copy No. Date: Examination: Histopathological examination (cito). Internal invoice No. Cost of diagnostic procedure. Examination No.: Patient: XXX PESEL: XXX Age: Gender: Material: 1. Multiple organ resection -- sigmoid colon Unit in charge:. Physician in charge: Material collected on: Material received on Expected time of examination:. Clinical diagnosis: Cancer of the sigmoid colon Examination performed on Macroscopic description:. A 15.2 cm length of the large intestine with a piece of mesentery sized 15 x 6.5 x 2.5 cm. Ulcerous tumour sized 4.2 x 6.5 x 0.8 cm in the mucosa. The lesion surrounding 90% of the intestine circumference, removed 7.2 cm from the incision line and 5.3 cm from the opposite one. Microscopic description: Adenocarcinoma tubulopapillare (G2). Infiltratio carcinomatosa profunda tunicae muscularis priopriae et telae adiposae mesenterii pericolicae.. Incision lines free of neoplastic lesions. Metastases carcinomatosae in lymphonodo (NO I/VIII) Infiltratio carcinomatosa capsulae lymphonodi. Emboliae carcinomatosae. Histopathological Diagnosis: Adenocarcinoma tubulopapillare coli. Tubulopapillar adenocarcinoma of the colon.. Metastases carcinomatosae in Iymphonodo. Cancer metastases in the Iymph nodes (NO I/vill).. (G2, Dukes C, Astler - Coller, C2, pT3, pNI). Compliance validated by: CONTACT YOU DOCTOR WITH THIS REPORT!
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diff --git a/output/text/bddfb571-3cd9-4756-bdfc-8a89caf494cd.txt b/output/text/bddfb571-3cd9-4756-bdfc-8a89caf494cd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..671eb2d79feb3cb39782e019fe5a2d07d174a11c
--- /dev/null
+++ b/output/text/bddfb571-3cd9-4756-bdfc-8a89caf494cd.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Phon Final Surgical Pathology Report Procedure: Diagnosis A. Right kidney, partial resection: Papillary renal cell carcinoma, 2.7 cm, , margins negative but close. B. Right kidney, deep margin, biopsy:. No carcinoma identified. Microscopic Description: Microscopic examination performed:. A. Type: Papillary carcinoma Histologic grade (Fuhrman Nuclear Grade: 3. Primary tumor (pT): 2.7 cm, pT1 Margins of resection: negative but close, < 1mm Regional lymph nodes (pN): none submitted Distant metastasis (pM: cannot be evaluated by this specimen. Vascular invasion: not identified Non-neoplastic kidney:  unremarkable Other findings: none. B.  Sections of the deep margin show no evidence of malignancy.. Specimen A.  Right renal mass B. Right kidney, deep margin. Clinical Information Right renal mass Intraoperative Consultation right kidney, deep margin, biopsy: No malignancy identified Gross Description A.  Received is a container labeled with the patient's name, medical. record number and "right renal mass". The specimen consists of a circumscribed piece of tan-brown tissue measuring 2.8 x 3.1 x 2.5 cm. The surgical margin is inked black the specimen is serially sectioned. is occupied by a circumscribed lesion which is. yellow-brown and necrotic..  A thin fibrous capsule and nests the cystic mass. The entire specimen is submitted in Al to A5. B. Container B. is labeled with the patient's name, medical record. number and "deep margin". The specimen consists of a single piece of tissue measuring 0.6-0.6 x 0.3 cm. All submitted in BFS..
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diff --git a/output/text/bdf71a1b-adff-49d7-9057-3e77018ce8b1.txt b/output/text/bdf71a1b-adff-49d7-9057-3e77018ce8b1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..06703c3cf0c3e9bac57a107c1d1d78318c8cbdea
--- /dev/null
+++ b/output/text/bdf71a1b-adff-49d7-9057-3e77018ce8b1.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:73D61A64-9435-4E72-898C-3A4E7C109CF3 TCGA-VS-A9UB-01A-PR Redacted (MM/DD/YYYY) PATHOLOGY REPORT: PRIMARY SITE: Cervix Biopsy of uterine cervix: - Poorly differentiated invasive squamous cell carcinoma. - Angiolymphatic and perineural invasions not observed.. ZD6 3 'areenone, nguarmsue 807013 c0 NS S.te.CerwyNos A53c sJ3/7/14 h 1A9/) 13/43
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diff --git a/output/text/be2e3fb2-f9df-460c-a8cc-fbf40ae880c7.txt b/output/text/be2e3fb2-f9df-460c-a8cc-fbf40ae880c7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..bc111f3386cb4e9d9ac35b4d2d568cab01075ae3
--- /dev/null
+++ b/output/text/be2e3fb2-f9df-460c-a8cc-fbf40ae880c7.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UUID:09349C95-780D-4218-B84F-8D14C9332A3A TCGA-LN-A7HZ-01A-PR Redacted IRB APPROVED Clinical Case Report ID-O 3 (For Collection of Cancerous Tissue) Carsnone, Rguamnsus ~D~8o7s|3 ce0Q nos Sute 073.3 Informed Consentd  id/1s/13 I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at Our institution. Name of Physician or Study Coordinator Signature Date Clinical Information GENERAL INFORMATION Date of Birth (mm/dd/yyyy) Height Marital Statusd Race Temperature  Single yzMarried Gender Welght  Divorced  Widow  Blood Pressure Heart Rate Male  Female HISTORY OF PRESENT ILLNESS Chief Complaints: : Tus wh& awaIlouiny Symptoms: TiLeel of lcitiny j Uea(neN Clinical Findings: Performance Scale (Karnofsky Score):  100 Asymptomaticx80-90 Symptomatic but Fully Ambulatory  60-70 Symptomatic, in bed less than 50% of day  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden. 20-30 Bed Ridden CURRENT MEDICATIONS Drug Dose Route Frequency Date (mm/dd/yyyy) To To ! To 1 To / 1 To 1
+
+--- Page 2 ---
+PAST MEDICAL HISTORY Diagnosis/Disease/Disorder/Iniury  Diagnosis Date Treatment Status OB/GYN HISTORY Menopausal Status Date of First Menses # of Pregnancies  Pre-menopausal  Peri-Menopausal Date of Last Menses # of Live Births  Post-menopausal Birth Control:  Condom  Oral Contraceptive  IUD  Hormone Replacement  Other: Therapy: SOCIAL HISTORY Occupatlon: Environmental Hazards: Smoking History Current Status TYPE  Packs/day Duration When Quit YES nO y/dcw] Stll Sxe () Alcohol Consumption Current Status TYPE Drinks/day Duration When Quit YES   NO Ldrnle [cce) Drug Use Current Status TYPE Frequency Duration When Quit  YES WNO (yrs) (r) FAMILY MEDICAL HISTORY Relative Dlagnosis Age of Diagnosis  LAB DATA Test Result Date Test Result Date HIV Negative  Positive: CEA   Negative  Positive: Hep B Negative  Positive: CA 15-3   Negative  Positive: Hep C  Negative  Positive: CA 19-9   Negative  Positive: AFP  Negative  Positive: PSA   Negative  Positive: Other: Other:  Negative  Positive:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+DIAGNOSTIC STUDIES Study Results Date Ultrasound X-Ray CT Endoscopy  A tuoouy Wces foana w to cesopaguy MRI Biopsy CLINICAL DIAGNOSIS Preoperative Clinical Diagnosis Location of Suspected Involved Lymph Nodes. Location of Suspected Distant Metastasis Cllnical Staging. Date of Diagnosis t2 Nc MO Stage: IA Treatment Information SURGICAL TREATMENT Procedure Date of Procedure Peectw  the ' Primary Tumor Organ  Detailed Location Size tSoyaglZiR 4x2 x4 cm Extension of Tumor Lymph Nodes Description Location of Lymph Nodes # of Lymph Nodes Palpable, Non-Dissected Lymph Nodes. Dissected Lymph Nodes Distant Metastasis Organ Detailed Location Size Surgical Staging T 2 N. mo Stage: LA NEOADJUVENT THERAPY (Chemo, Radiation, Immuno, Hormonal, or Molecular) Drug/Treatment Dose Route Frequency Date (mm/dd/yyyy) To To ! 1 To / To / To / / 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Date: .. Time: Collected by: Date: -- .Time:. Preserved by: SPECIMEN TYPE (# of samples provided) Paraffin Block  Blood/Serum/Plasma Slide Frozen Diseased Diseased Normal  Diseased Normal Normal Diseased Normal 2 ? 7 Time to Formalin Time to LN2 Time to LN2 min min min PATHOLOGICAL DESCRIPTION Primary Tumor Size Extenslon of Tumor Distance to NAT Organ 6 2So y Awire 4 xZx/ cm lipepThied cm Lymph Nodes // Location # Examined # Metastasized Distant Metastasis Organ Detailed Location Size Pathological Staging N o mO pT z Stage: Notes:
+
+--- Page 5 ---
+Irb AppROVeD Consolidated Pathology Diagnosis. Cell Distribution. + Structural Pattem Diffuse + I Streaming Mosaic Storiform Necrosis Fibrosis Lymphocytic Infiltration Palisading Vascular Invasion Cstic Degeneration Clusterized Bleeding Aiveolar Formation Myxoid Change  Indian File /Psammoma/Calcification Squamous + Adenomatous +  Sarcomatous +  Lymphomatous+  Squamoid Cell Glandular cell Round Cell  Large Cell  Spindle Cell Cell Stratification Fibroblast Small Cel! Keratin  Secretion Osteoblast RS Cell/RS Like Desmosome Intracyt. Vacuole Lipoblast Inflam. Cell Pear Gland formation Myoblast  Plasma Cell Cellular Differentiation:d  Wel! Moderate  Poor Nuclear Atypia: 0 I II Aniso Nucleosis III 4Z Hyperchromatism Nudeolar Prominent Y  Muitinucleated Giant Cell Mitotic Activity Nuclear Grade: Final Pathology Report Histological Diagnosis: Csrsss (ell Cau s n cne..Grade:_ Comments: Date Director, Research Pathology. lw 8/3o/s INTEGRATED REPORT OF FINDINGS BY COLLABORATORS AND PATHOLOGISTS -- sis Discrepancy Piu Makgnancy History Casei QUALIFIS 833 iewer Initials
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diff --git a/output/text/be6963e2-a9db-4d3e-a34b-c4cb9a93c433.txt b/output/text/be6963e2-a9db-4d3e-a34b-c4cb9a93c433.txt
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index 0000000000000000000000000000000000000000..9c527010cb797bb6089adbe84c6872195ff40863
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+
+--- Page 1 ---
+SURGICAL PATHOLOGY REPORT SPECIMEN Right hemicolectomy CLINICAL NOTES PRE-OP DIAGNOSIS: Hepatic flexure cancer POST-OP DIAGNOSIS: Same GROSS DESCRIPTION Received fresh in a container labeled "right hemicolectomy". is a segment of bowel consisting of 6 cm of terminal ileum with contiguous 23 cm of proximal colon. The serosal surface is glistening and tan-pink, and there is a moderate amount of attached adipose tissue.  There is an unremarkable appendix present, measuring 6.5 cm long x 0.7 cm in diameter. On cut surface, it is without focal lesion, without gross evidence of inflammation. The bowel measures 3.6 cm and 8 cm in circumference at the proximal and distal resection margins respectively. The bowel is opened, and there is a circumscribed 5.3 x 5 cm rubbery white-pink mass located. 11 cm proximal to the distal margin. A portion of tumor and of normal tissue ar submitted  for the clinical requested. On sectioning, the tumor has a maximum thickness of 1.6. cm, and grossly extends through the musuclaris propria and into surrounding adipose tissue. It is 1 cm from the outer surface of the specimen.  The remainder of the bowel wall averages 0.5 cm thick and has a tan-pink glistening mucosa with a normal pattern and folds. The adipose tissue is dissected, and soft tan lymph nodes are identified up to 1.8 cm in greatest dimension..  RS-17, following fixation. BLOCK SUMMARY: 1 - proximal and distal resection margins; 2-6  tumor, including relation to uninvolved tissue; 7 - ileocecal valve;  - random colon; 9 - appendix; 10-12 - multiple lymph nodes per block; 13-15 - one sec ed lymph node per block; 16,17 - sectioned largest lymph node. MICROSCOPIC DESCRIPTION The following template summaries the findings in this case: Histologic type: Adenocarcinoma of the colon Histologic grade:  Moderately differentiated Primary tumor (pT): Adenocarcinoma invades through the full thickness of the bowel wall and into surrounding adipose tissue (pT3). Proximal margin: Negative Distal margin:  Negative Circumferential (radial) margin:  Negative Distance of tumor from closest margin: See gross description Vascular invasion: Not identified Regional lymph nodes (pN): pN1c. Twenty-one negative lymph nodes are identified and they are negative for malignancy. However in block #12, on deeper levels, there is a tumor nodule identified in. fat without histologic evidence of residual lymph node tissue, and
+
+--- Page 2 ---
+given the presence of this tumor deposit, this is pNlc. Non-lymph node pericolonic tumor: See above Other findings: Appendix without specific diagnostic abnormalities. DIAGNOSIS Terminal ileum, appendix, and right colon, excision - Moderately differentiated adenocarcinoma of the colon, invading through the full thickness of the muscularis propria and into surrounding adipose tissue (see microscopic description). - Margins negative for malignancy. Tumor deposit identified in pericolonic fat, and twenty-one lymph nodes negative for malignancy (pNlc). ifiC malities.  End Of Report
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diff --git a/output/text/be7ad45d-05de-4cc8-83d2-3bebaf45d6bd.txt b/output/text/be7ad45d-05de-4cc8-83d2-3bebaf45d6bd.txt
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index 0000000000000000000000000000000000000000..6020f478902c7e278764a3dee532a6a07883f6c6
--- /dev/null
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+
+--- Page 1 ---
+E Surgical Pathology Report. * Final Report * 1cd-o-3 carcinoma Jobular,I nhltrating 85a0)3 Result type: Suraical Patholoav Reoort Site: breast , Nos Result date: Signed c S0.9 Result status: 5112 Result title: Suraicai Patholoav Reoort RD Performed by: Verified by: Encounter info: * Final Report * Clinical History Riaht hraast pleomorphic ILc triple positive on prior core at 9:00 position. E-cadherin immunostain was negative on core Specimen #1 Sentinel node #1, right axilla, hot and blue #2 Sentinel node  #2, right axilla, hot and blue #3 Sentinel node #3, right axilla, hot and blue #4 Right breast  lumpectomy stitch, single long/cranial, double short/medial #5 Right breast mass, cranial margin #6 Right breast mass, medial: margin #7 Right breast mass, caudal margin #8 Right breast mass, lateral margin #9 Right breast mass, deep margin Gross Examination #i* Received fresh labeled sentinel node #l, right axilla, hot and blue is a l.2 x 0.6 x 0.5 cm portion of tan-yellow fibroadipose tissue.  Within the tissue is longitudinal axis, and one alcohol-fixed touch preparation. as well as one scrape preparation are prepared from the cut surface. The candidate is entirely submitted as two sections in one cassette. #2 Received fresh labeled sentinel node #2, hot and blue, right axilla is a 1.2 x 0.5 x 0.4 cm portion of tan-yellow fibroadipose tissue.  Within the tissue is. a 0.4 x 0.4 x 0.4 cm lymph node candidate.  The candidate is hisected along its longitudinal axis, and one alcohol-fixed touch preparation ) as well as ) are prepared from the cut surface. The candidate one scrape preparation is entirely submitted as two sections in one cassette. #3 Received fresh labeled sentinel node #3, right axilla, hot and blue is a 1.3 Printed by: UUID: CA0CD57E-DA92-463E-A004-D554825A2206 Page 1 of 4 TCGA-AC-A3W5-01A-PR Reda. ted Printed on: (Continued)
+
+--- Page 2 ---
+Surgical Pathology Report : * Final Report *. x 0.7 x 0.6 cm portion of tan-yellow fibroadipose tissue. Within the tissue is a 0.8 x 0.5 x 0.4 cm lymph node candidate. The candidate is bisected along its longitudinal axis, and one alcohol-fixed touch preparation. as well as. one scrape preparation are prepared from the cut surface. The candidate is entirely submitted as two sections in one cassette. double short medial, is a 5.8 cm (cranial to caudal) x 4.2 cm (medial to lateral) x 2.0 cm (superficial to deep) portion of fibroadipose tissue, oriented. as stated above.  The superficial margin is inked blue and the deep margin is inked black. Sectioning demonstrates a stellate, moderately well circumscribed 2.6 x 2.2 x 1.0 cm white, indurated mass.. Within the mass is a 0.4 cm in greatest dimension hemorrhagic biopsy cavity.  The mass demonstrates the following measurements of the margins: medial-0.3 cm, lateral-0.9 cm,  The remainder of the parenchyma is composed entirely of lobulated adipose tissue. There are no additional discrete mass lesions or nodules identified.  Seven sections are submitted in seven: "A-g". Block summary: "A", medial perpendicular; (differentially inked) perpendicular; "p", superficial perpendicular; "e", deep perpendicular; "y", caudal shave; "g", cranial shave. Representative fresh tumor and normal tissue provided to I and the. #5 Labeled right breast mass, cranial margin, is a 5.0 x 3.2 x up to 1.3 cm cup-shaped portion of tan yellow fibroadipose tissue, oriented with a cranial map marker on one surface."  The cranial margin is inked black and tangential. sections are taken. The remaining tissue is serially sectioned to demonstrate no gross focal mass or lesion. Six representative sections are submitted in. perpendicular sections through the remaining tissue. #6 Labeled right breast mass, medial margin, is a 3.0 x 3.0 x up to 1.0 cm. cup-shaped portion of tan yellow fibroadipose tissue, oriented with a medial map marker on one surface.  The medial margin is inked black. The tissue is serially sectioned to demonstrate no gross focal mass or lesion. The tissue is. entirely submitted as nine perpendicular sections in six: "A-r".. cup-shaped portion of tan yellow fibroadipose tissue, oriented with a caudal map  The caudal margin is inked black. The tissue is serially sectioned to demonstrate no gross focal mass or lesion. The tissue is entirely submitted as eight perpendicular sections in five: "A-e". Printed by: Page 2 of 4 Printed on: (Continued)
+
+--- Page 3 ---
+Surgical Pathology Report * Final Report * #8 Labeled right breast mass, lateral margin, is a 3.3 x 2.3 x up to 0.9 cm cup-shaped portion of tan yellow fibroadipose tissue,  oriented with a lateral. map marker on one surface. The lateral margin is inked black. The tissue is serially sectioned to demonstrate no gross focal mass or lesion. The tissue is. entirely submitted as eight perpendicular sections in four: "A-D".. 9  Labeled right breast mass, deep margin, is a 5.0 x 3.2 x up to 1.6 cm. cup-shaped portion of tan yellow fibroadipose tissue, oriented with a deep map. marker on one surface. The deep margin is inked black, and tangential sections. are taken. The remaining tissue is serially sectioned to demonstrate no gross focal mass or lesion. Seven representative sections are submitted in five: "A-E"  Block summary: sections through the remaining tissue.. OR Consultation SENTINEL NODE #1 RIGHT AXILLA (1 LN, 1 TP, #1 1 SCRAPE) : NEGATIVE (0/1). #2 SENTINEL NODE  #2 RIGHT AXILLA (1 LN, 1 TP, 1 SCRAPE) : NEGATIVE (0/1). SENTINEL NODE #3 RIGHT AXILLA (1 LN, #3 1 TP. SCRAPE' (0/1). #1-#3 REPORTED TO DR. AT ON Signature Line Signed by: ELECTRONIC SIGNATURE Microscopic Examination #1-#9 Microscopic examination performed. Immunostain for pancytokeratin is. evaluated on ali blocks in parts 1-3 and show no metastatic carcinoma. The final medial margin is positive in block 6F (Dr.. Comment The pleomorphic Lcis noted at the final medial margin is remote from the main. tumor mass and likely represents an incidental finding. Final Dlagnosis #1 SENTINEL LYMPH NODE #1, RIGHT AXILLA, EXCISION: NEGATIVE (O/1). #2 SENTINEL LYMPH NODE #2, RIGHT AXILLA, EXCISION: NEGATIVE (O/1).) #3 SENTINEL LYMPH NODE #3, RIGHT AXILLA, EXCISION: NEGATIVE (O/1). Printed by: Page 3 of 4 Printed on: (Continued)
+
+--- Page 4 ---
+111 Surgical Pathology Report. E * Final Report * #4  BREAST MASS, RIGHT AT 9:OO, EXCISION: INVASIVE LOBULAR CARCINOMA, PLEOMORPHIC TYPE, HIGH GRADE. TUBULE FORMATION: MINIMAL (SCORE 3). PLEOMORPHISM: MARKED (SCORE 3). MITOTIC COUNT: MODERATE (SCORE 2). TOTAL NOTTINGHAM SCORE: 8 OF 9 (GRADE III). SIZE OF TUMOR: 2.6 CM OF INVASIVE CARCINOMA. PERCENT OF IN SITU CARCINOMA: 1-2% (PLEOMORPHIC LCIS). STATUS OF BREAST TISSUE AWAY FROM LESION: BENIGN. LOCAL LYMPHATIC SPACE STATUS: NEGATIVE. DERMAL LYMPHATIC SPACE STATUS: N/A. SURGICAL MARGIN STATUS:S SUPERFICIAL: NEGATIVE (O.4 CM). DEEP: NEGATIVE (0.5 CM). MEDIAL: NEGATIVE (0.7 CM). LATERAL:  NEGATIVE (0.5 CM). CRANIAL:  NEGATIVE. CAUDAL:  POSITIVE FOR PLEOMORPHIC LCIS. STATUS OF MICROCALCIFICATIONS: ABSENT. ESTROGEN RECEPTOR ASSAY: POSITIVE ON PRIOR CORE (3+, SO%). PROGESTERONE RECEPTOR ASSAY: POSITIVE ON PRIOR CORE (3+, 3O%). HERCEPTEST: POSITIVE ON PRIOR CORE (IHC SCORE 3+, FISH POSITIVE). #5 CRANIAL MARGIN, RIGHT BREAST: NEGATIVE. #6  MEDIAL MARGIN, RIGHT BREAST: FOCAL PLEOMORPHIC LCIS (O.4 CM). FINAL MARGIN IS POSITIVE OVER A LENGTH OF O.2 CM. #7 CAUDAL MARGIN, RIGHT BREAST: FOCAL PLEOMORPHIC LCIS (O.1 CM). FINAL MARGIN IS NEGATIVE (O.5 CM). #8 LATERAL MARGIN, RIGHT BREAST: FOCAL PLEOMORPHIC LCIS (O.3 CM). FINAL MARGIN IS NEGATIVE (O.6 CM). #9 DEEP MARGIN, RIGHT BREAST: NEGATIVE. PATHOLOGIC STAGE: pT2 pNO(sn) (i-). Ordering Provider Ordering. Physician: Page 4 of 4 Printed by: (End of Report) Printed on:
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diff --git a/output/text/bea37db4-b973-47b2-a3d1-2d759858f393.txt b/output/text/bea37db4-b973-47b2-a3d1-2d759858f393.txt
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index 0000000000000000000000000000000000000000..e8c91ebb0d2bd2d65369d11ab7d1d17bc8616dfd
--- /dev/null
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+JCs-0 - 3 Can mr, mfilt/atry dustd, Nos 8500f3 M ofr/u1 Site: bruot,nos C50.9 UUID:40B58A7A-2A05-4AAF -B1D4-B418E4A56115 TCGA-AQ-A04L-01A-PR Red SURGICAL PATHOLOGY Tumor identifier Diagnosis: A: Breast, left, mastectomy. - Non-proliferative fibrocystic change. - No atypia or malignancy identified. B: Sentinel lymph node #l, removal. - One benign lymph node, negative for malignancy. C: Sentinel lymph node #2, removal One benign lymph node, negative for malignancy. (D:) Breast, right, mastectomy. Invasive ductal carcinoma, Overall grade 3. The tumor size is 2.5 cm. No 1ymphovascular space invasion is identified. Surgical margins are free of. invasive carcinoma. - Tumor estrogen receptor positive, progesterone receptor negative. - her2/neu overexpressed (score-3+).  Ductal carcinoma in situ, comedo subtype, nuclear grade 3 with necrosis, comprising approximately 5% of the tumor. The surgical margins are negative for DCIS. Comment: Additional levels of the sentinel nodes performed as per sentinel lymph node protocol are all negative for carcinoma.. Clinical History: The patient is a -year-old female with right breast. carcinoma and a left breast mass who undergoes bilateral mastectomy and sentinel node biopsy mapping. Gross Description:. Received are four appropriately containers.. Container A is additionally labeled "left breast, short. superior, long lateral." Specimen fixation: received fresh and placed in formalin
+
+--- Page 2 ---
+Type of mastectomy: simple mastectomy Size of specimen: 21.5 x 13.5 x 3.5 cm Orientation of specimen: a long suture marks the lateral aspect while a short suture marks the superior aspect; the superficial margin is marked with blue ink and the deep. resection margin is marked with black ink Skin ellipse dimensions: 9.4 x 3.3 x 0.2 cm; no discrete. lesions or abnormalities are noted grossly Nipple/areola: the slightly retracted nipple measures 1.5 cm in diameter and is surrounded by a grossly unremarkable areola which measures 3.6 cm Axillary tail: not present Biopsy site: not identified Residual tumor: no tumor is identified grossly Location of tumor: not applicable Distance of mass/biopsy site from surgical margin: not applicable Gross involvement of skin of fascia/muscle by tumor: not applicable Description of remainder of breast: yellow/tan lobulated unremarkable adipose is admixed with focally dense and coalescening pale pink/white breast tissue without masses or nodules appreciated grossly Other remarkable features: none Tissue submitted for special investigations: none. Al - nipple and areola A2-A4 - representative sections of the lateral most adipose. tissue or possible lymph node which are not identified grossly A5,A6 - representative sections upper/inner quadrant A7,A8 - representative sections of upper/outer quadrant A9,Alo - representative sections of lower/outer quadrant. Al1,A12 - representative sections of lower/inner quadrant Container B is additionally labeled "sentinel lymph node #1" and consists
+
+--- Page 3 ---
+of an ovoid, pale gray/tan lymph node measuring 1.8 x 0.8 x 0.6 cm. The lymph node is bisected and submitted in block Bl. Container c is additionally labeled "sentinel lymph node #2" and consists of an ovoid, gray/purple lymph node measuring 6 mm in greatest. dimension. The lymph. node is bisected and submitted entirely in block cl.. Container D is additionally labeled "right breast." Specimen fixation: received fresh and placed in formalin. Type of mastectomy: simple. Size of specimen: 20.5 x 15.5 x 4.0 cm Orientation of specimen: a long suture marks the lateral aspect while a short suture marks the superior aspect; the superficial aspect is marked with blue ink and the deep resection margin is marked with black ink Skin ellipse dimensions: 13.8 x 4.2 x 0.2 cm; scars and lesions are not identified grossly, however, the specimen. at the skin has previously been dyed blue at the time of surgery Nipple/areola: the grossly unremarkable nipple measures 1.5 cm in diameter and is surrounded by an unremarkable. 4.3 cm areola Axillary tail: not identified grossly Biopsy site: not identified. Residual tumor: A 2.5 x 2.0 x 1.8 cm indurated, pale gray/white, previously dyed blue, well. circumscribed ovoid mass is identified. Location of tumor: in the outer half of the specimen, at the junction of the. upper and lower halves. Distance of mass/biopsy site from surgical margin: the mass. extends to within. 5 mm
+
+--- Page 4 ---
+of the deep resection margin, is 7.5 cm from the inferior peripheral margin, and 8.0 cm from the superior peripheral margin Gross involvement of skin of fascia/muscle by tumor: absent Description of remainder of breast: grossly unremarkable, yellow/tan lobulated adipose admixed with focally dense, pink/white breast tissue without additional masses or nodules identified grossly Other remarkable features: none Tissue submitted for special investigations: a 1.5 x 1.5 x 0.8 cm fragment of. tumor is submitted to Tissue Procurement. D1 - nipple and areola D2-D4 - representative sections of the lateral most aspect of adipose. tissue or possible lymph nodes which are not identified grossly D5,D6 - largest dimension of tumor, with closest deep resection margin. D7 - additional section of tumor D8-Dll - representative sections of the four breast quadrants, upper/inner, lower/inner, lower/outer, upper/outer respectively (ec) Light Microscopy: Light microscopic examination is performed by Dr. Specimen A: The left breast mastectomy specimen (specimen A) shows non- proliferative fibrocystic change. There is no evidence of atypia or malignancy. (Specimen D - right breast) Presence/absence of invasive carcinoma: present Histologic tumor type/subtype: ductal Histologic grade: Overall grade - 3. Architectural grade - 3
+
+--- Page 5 ---
+Nuclear grade - 3. Mitotic grade - 3 Focality of tumor: unifocal Tumor size (greatest dimension): 2.5 cm Tumor necrosis: focal single cell necrosis is present but no geographic. zones of necrosis are identified Invasion: Lymphatics - not identified Blood vessels - not identified Perineural spaces - not identified Skin - Nipple (Paget's disease) - not identified Fascia/muscle - not identified Histologic assessment of surgical margins of invasive carcinoma: negative for tumor; tumor extends to within. approximately 5 mm of the deep margin. Other remarkable histologic features: none Results of special investigations (Block #d6): ER (by immunohistochemistry): positive-(2+, 60%) PR (by immunohistochemistry): negative C-erbB-2 (by immunohistochemistry: 3+ membranous staining Presence/absence of carcinoma in situ: present Type/subtype of carcinoma in situ: ductal, comedo subtype Focality of carcinoma in situ: multifocal If Dcis, nuclear grade/presence or absence of necrosis: nuclear grade 3. with necrosis Relationship of carcinoma in situ to invasive tumor: associated with and adjacent to invasive carcinoma Relative amount of carcinoma in situ: 5% Presence/absence of extensive intraductal component (Eic): absent Histologic assessment of surgical margins of carcinoma in situ: negative for. tumor Other significant findings: none. Axillary lymph nodes: adipose tissue from the tail of the breast is submitted no axillary lymph nodes are identified. Signature:
+
+--- Page 6 ---
+I have personally conducted the evaluation of the above specimens and have. rendered the above diagnosis(es).. Electronically signed out by:. MD Date:
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diff --git a/output/text/bea43641-32be-414e-87b2-3207cb901b55.txt b/output/text/bea43641-32be-414e-87b2-3207cb901b55.txt
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index 0000000000000000000000000000000000000000..58bdd066149b56a25d3a73b163f00fb6410c78c2
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+
+--- Page 1 ---
+E/xe98 BREAST TISSUE CHECKLIST my Specimen type: Radical mastectomy "JyE Specimen size: Not specified Tumor site: Breast Tumor size:2.4 x 2.4 x 2.4 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal and lobular carcinoma Histologic grade: Tumor extent: Not specified Lymph nodes: 0/11 positive for metastasis ( 0/11) (Left)lower Extracapsular invasion of the lymph nodes: Not specified ym9 outer Margins: Not specified E-0-00 quadrant Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments:None.
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diff --git a/output/text/bebee127-d6da-467c-b37b-873449729fec.txt b/output/text/bebee127-d6da-467c-b37b-873449729fec.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5b7e902cbc09b89f2ca56d216f56941ea5a9cdea
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+
+--- Page 1 ---
+/cs-0-3 eaucnona mfiIf^atiNg duct,Nos 85oo/3 8ite: brnot N0s C50.9 4/7/11 Procurement Date: Laterality:Left, upper outer quadrant Path Report:BREAST TISSUE CHECKLIST Specimen type: Radical mastectomy Specimen size: Not specified Tumor site: Breast Tumor size: 3.5 x 3 x 3 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinoma Histologic grade: Poorly differentiated Tumor extent: Not specified Lymph nodes: 0/6 positive for metastasis (Regional 0/6) Extracapsular invasion of the lymph nodes: Not specified Margins: Not specified Nottingham Histologic Score Tubule formation: Not specified. Nuclear pleomorphism: Not specified UUID:E34F48F0-A0C3-4C72-8E3A-F319D4CDDD5D TCGA-E9-A22G-01A-PR Redacted Mitotic count (25x): Not specified. Mitotic count (40x): Not specified. Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None
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diff --git a/output/text/beeb4497-34ff-4295-8716-7d58cf985d64.txt b/output/text/beeb4497-34ff-4295-8716-7d58cf985d64.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c624cbf6ebe817c90d484e0b6f99948f340cb37d
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+/cD-0-3 Carunome, mfit+rathy ductel, nos 85osf3 Site: breast Nos cs0.9 y/3ufn h YOR OFFICIAL USE ONLY - PERSONAL DATAS SURGICAL PATHOLOGY REPORT Patient: Specimen #: FMP/SSN: DOB/Age/Sex: Race: WHITE Taken: Location: Received: Physician(s) : Reported: ** AMENDED* * SPECIMEN : A: SENTINEL LYMPH NODE #1 B: SENTINEL LYMPH NODE #2 C: RIGHT BREAST TISSUE D: FINAL DEEP MARGIN FINAL DIAGNOSIS: A. LYMPH NODE, SENTINEL #1, BIOPSY: POSTIVE FOR MICROMETASTASIS (largest deposit 0.6 mm) IN ONE OF TWO LYMPH NODES (1 of 2) B. LYMPH NODE, SENTINEL #2, BIOPSY: NEGATIVE FOR METASTASIS IN ONE EXAMINED LYMPH NODE (Multiple sections stained by hematoxylin & eoson and by. immunohistochemistry for keratin) C. BREAST TISSUE, RIGHT, LUMPECTOMY: INVASIVE DUCTAL CARCINOMA, MODERATELY DIFFERENTIATED BY COMBINED HISTOLOGICAL CRITERIA (TUBULES=3, NUCLEAR SIZE-2, MITOSES-1; TOTAL=6) . MAXIMUM SIZE = 1.4CM (SLIDE C1). SUPERIOR-ANTERIOR MARGIN INVOLVED BY TUMOR (SLIDE C23). OTHER MARGINS NEGATIVE FOR TUMOR. DUCTAL CARCINOMA IN SITU, SOLID AND CRIBRIFORM-TYPE WITH NECROSIS (SLIDE C5).  FIBROADENOMA. FIBROCYSTIC CHANGES INCLUDING APOCRINE METAPLASIA AND USUAL DUCTAL HYPERPLASIA. D. BREAST, DEEP MARGIN, EXCISION: - BENIGN FIBROADIPOSE TISSUE AND SKELETAL MUSCLE. - NEGATIVE FOR TUMOR. COMMENT : The report is ammender. to report evaluation of sentinal lymph nodes during absence. UUID:A5D94D02-5423-4055-96E3-B5AA5799DC020 TCGA-A2-A0ER-01A-PR Redacted Page 1 Continued on Next Page  PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 2 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: FINAL DIAGNOSIS (continued): ** Report Electronically Signed Out **. CLINICAL DIAGNOSIS AND HISTORY: year old female with history of a right breast mass. PRE-OPERATIVE DIAGNOSIS: Right breast cancer GROSS DESCRIPTION: A. SENTINEL LYMPH NODE #1 Received fresh is a 2.5 x 1.7 x 1.5 cm fatty tissue fragment containing 2.2 x 1.4 x 1.4 cm lymph node. Half of the node is submitted for the cBc protocol. The remaining half is submitted for paraffin section in one cassette. B. Received fresh is a 2.0 x 1.8 x 1.5 cm fatty tissue fragment containing. a 1.5 x 1.2 x 1.2 cm lymph node. Half of the node is submitted for the CBC. protocol. The remaining half is submitted for paraffin sections in a. single cassette. C. Received fresh is a fibrofatty tissue fragment, oriented with sutures (short-superior, long-lateral) measuring 7.5 x 5.5 x 1 cm. A needle. localization wire is in place. The accompanying radiograph is reviewed and. shows a well defined density alongside the locaation wire and about 1 cm from a metallic clip. Inked: blue- superior-anterior, green- inferior-. anterior, black-posterior. The specimen is sectioned from lateral to. medial revealing a 1.3 x 1.0 x 0.7 cm tumor with tan gritty cut surface in. the mid portion of the specimen. The tumor is located 0.3 cm from the deep. margin and 0.3 cm from the inferior anterior margin. The remaining tissue is variably fatty and fibrous. Two tissue sections submitted for CBC. protocol with matching paraffin sections as follows:. C1: tumor c2: fibrous area near lateral margin approximately 2 cm from tumor.. Additional sections are submitted as follows: c3-c4: lateral to fibrous area paired cassettes. c5-c6: medial to fibrous area paired cassettes. c7-c8: paired cassettes Page 2 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974S
+
+--- Page 3 ---
+FOR OrFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 197 SURGICAL PATHOLOGY REPORTS Patient: Specimen #: GROSS DESCRIPTION (continued) : c9-c10: paired cassettes c11-c13: matched cassettes c14-c16: matched cassettes lateral to tumor c17-c18: paired cassettes medial to tumor C19-c21: matched cassettes c22-c23: paired cassettes c24-c25: paired cassettes. D. Received in formalin and labeled with the patient's name and designated FINAL DEEp MARGIN is a single fragment of yellow-tan. fibrous tissue measuring 3.5 x 2 x 1 cm. Inked entirely in black. Serial sectioning reveals unremarkable fibroadipose tissue mostly adipose. Tissue is entirely submitted Page 3 End of Report FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
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diff --git a/output/text/bf0b027d-b22d-4230-aafa-abf9d975b1b8.txt b/output/text/bf0b027d-b22d-4230-aafa-abf9d975b1b8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e602ab5c96df5f5e4e729908e959c0c15545be78
--- /dev/null
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+
+--- Page 1 ---
+Patient Name: Accession #: Med. Rec. #: Date of Procedure. DOB: Dato of Roceint: Gender: Date of Report: Rof. Physician: Account #: Billing Type Patient Address: Additional Copy to. Rel. Source: osis & History: th right renal mass. Specimens Submitted:. 1 Kidney. toft, upper pole tumor. biopsy ((s) (pjm) 2:Kidney,left, lower pole angiomyolipoma, excision(ll) 3:Lymph nodes,paia-aortic,excision (1l DIAGNOSIS: Kidney, left, upper pole tumor, biopsy Tumor Type.  Ronal coll carcinoma - Papillary type Fuhrman Nuclear Grade:.  Nuclear grade II/IV Tumor Size: Greatest diameter is 2.2 cm.. Local Invasion (for ronal cortical lypes): Not ldentified Renal Vein Invasion. Not identified Surgicat Margins:. Free of tumor (tumor is present within O.1 cn of inked renal parenchymal margin) Non-Neoplastic Kidney: Unremarkable Adrenal Gland: Not identifiod Lymph Nodes Not identified Staging for renal cell carcinoma/oncocytoma: pT1 Tumor <= 7.0 cm in greatest dimension limited to the kidney 2.Kidney, left lower pole angiomyolipona. excision(tl):. Fragmented angionyolipoma. Page 1 of 3
+
+--- Page 2 ---
+3. .Lymph nodes, para-aortic, excision (tl): Lymph Nodes:. Not involved Number of nodes examined:4 Note: This case was reviewed with the. ch concurs with the diagnosis. TATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL. EXAMINATION OF THE SLIDES (AND/OR OTRER MATERIAL). AND THAT IHAVE REVIEWED AND APPROVEO THIS REPORT Special Studles: Resull Special Stain Comment RECUT Gross Description:. 1). Tho specimen is roceivod fresh for frozen section consullation, ravered Lent uppor pore renanumor. stitch marks deep margin" and consists of a portion of brown-tan, kidney tissue measuring 3.5 x 2.5 x 1.8 cm, one stitch is identified designating the deep margin. The deep margin is nked in black and the specimen is serially sectioned to reveal a white-tan, ill defined nodular tumor measuring 2.2 x 1.8 x 1.3 cm.Representative sections are submitled for frozen section. The remaining specimen consists of a  portion of brown-tan kidney tissue, perviously inked in black and serially sectioned. Serial sections of the remaining specimen reveals a protruding white-lan nodular lunor measuring 2.2  .3 cm and localed abutling the deop black margin of tho specimen. Representative submilted. Section was given fc rotocol. Summary of sections: FSC -- frozen seclion control T-represenlativo sections of the tunor R-representative seclions uninvolved parenchyma 2).  The specimen is received in formalin, labeled 'Left renal tower pole angionyolipoma" and consists of a lriable fragment of lan soll tissue measuring 1.7 x 0.6 x 0.5 cm.Enlirely submitted. Sumary of sections. U-undesignated 3). The specimen is received in formalin, labeled "Para-aortic lymph nodes" and consists of four pink-tan firm lymph nodes ranging from 0.8 to 1.5 cm in greatest dimension.All identified lymph nodes are subrmitted. Summary of sections:. LN -- lymph nodes BLN-- bisected lymph nodes Summary of Sections: Part 1: Kidney, left, upper pole. tumor,biopsy(fs) (pjm Block Sect. Site PCs Page 2 of 3
+
+--- Page 3 ---
+F$C 1 N R 2 4 T 4 Part 2:  Kidnoy,left, lower pole angiomyolipoma, excision(tl) Block Sect. Site PCs 1 U 1 Part 3: Lymph nodes, para-aortic, excision (ll) Block Sect. Site PCs 2 BLN 4 1 LN 2 Intraoperntive Consultation: Nole: The diagnoses given in this section pertain only to the tissuo sample examined at the tine ol the intraoperative consullation. 1 FROZEN SECTION DIAGNOSI CORTICALNEOPLASM (COMES WITHIN O.O5 CM OF INKED MARGIN IN REPRESENTATIVE SECTION] PERMANENT DIAGNOSIS SAME Page 3 of 3 END OF REPORT
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diff --git a/output/text/bf20eab5-a834-4bf4-88ba-7fbe31e6c7b4.txt b/output/text/bf20eab5-a834-4bf4-88ba-7fbe31e6c7b4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..dd9fa5ebc5130334e8712d22b173457f8f4ebec4
--- /dev/null
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+
+--- Page 1 ---
+Diagnosis: Right hemicolectomy preparation with tumor-free oral and aboral resection margins, as well as an ulcerated, moderately differentiated adenocarcinoma in the region of the Bauhin's valve and the bordering cecum with infiltration of the perimuscular adipose tissue, and with four regional lymph node metastases (G2, pT3 L1 V0 local R0 pN2 4/23)
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diff --git a/output/text/bf5a8b52-6a9c-4c01-8cb8-b5a5bf6faace.txt b/output/text/bf5a8b52-6a9c-4c01-8cb8-b5a5bf6faace.txt
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index 0000000000000000000000000000000000000000..fa82f41e870473fbf2640580704a1461357cd736
--- /dev/null
+++ b/output/text/bf5a8b52-6a9c-4c01-8cb8-b5a5bf6faace.txt
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+
+--- Page 1 ---
+Page 1 of 6 UUID:BD4F0E43-3FE5-4059-875E-70E9988EF60F TCgA-XF-A9T0-01A-PR Redacted DIAGNOSIS: RADICAL CYSTOPROSTATECTOMY, LEFT NEPHROURETERECTOMY, LYMPH NODE DISSECTION AND CREATION OF STUDER NEO-BLADDER: 7CD 0-3 RIGHT DISTAL URETER (A) : 'erenoms,wrstlal NoS INTRAOPERATIVE FROZEN SECTION DIAGNOSIS: 812013 NO HIGH GRADE ATYPIA OR TUMOR IDENTIFIED FINAL DIAGNOSIS: Sute : Ysadder Nos BENIGN URETER C67.9  NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED HJ3[26|14) APICAL URETHRAL MARGIN (B) : INTRAOPERATIVE FROZEN SECTION DIAGNOSIS: NO HIGH GRADE ATYPIA OR TUMOR IDENTIFIED FINAL DIAGNOSIS: BENIGN URETHRAL AND PERIURETHRAL TISSUE NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED BLADDER / PROSTATE (C) : BLADDER: INVASIVE POORLY DIFFERENTIATED UROTHELIAL CARCINOMA (7.6 X 3.3 X 2.2 CM). GRADE 4/4, GROSSLY AND MICROSCOPICALLY EXTENDING THROUGH WALL OF BLADDER NECK TO INVOLVE PERIVESICAL SOFT TISSUE MULTIFOCAL (INCLUDING TRIGONE AND LEFT URETEROVESICAL JUNCTION) UROTHELIAL CARCINOMA IN SITU (FLAT LESION)  LEFT ATTACHED URETER, REACTIVE CHANGES WITHOUT UROTHELIAL DYSPLASIA OR MALIGNANCY  RIGHT ATTACHED URETER, NO SIGNIFICANT HISTOPATHOLOGIC CHANGE RESECTION MARGINS, FREE OF UROTHELIAL DYSPLASIA AND MALIGNANCY PROSTATE: UNILATERAL PROSTATIC ADENOCARCINOMA, GLEASON'S SCORE'7 (3+4). CONFINED TO PROSTATE WITHOUT CAPSULE OR PERIPROSTATIC SOFT TISSUE INVOLVEMENT MULTIFOCAL HIGH GRADE PROSTATIC INTRAEPITHELIAL NEOPLASIA (PIN III) PROSTATIC URETHRA, NO UROTHELIAL DYSPLASIA OR UROTHELIAL MALIGNANCY IDENTIFIED BILATERAL SEMINAL VESICLES, FREE OF MALIGNANCY RESECTION MARGINS, FREE OF MALIGNANCY AND UROTHELIAL DYSPLASIA LEFT KIDNEY D:  STENOSIS OF LEFT URETERAL PELVIC JUNCTION WITH ASSOCIATED MILD PELVIC DILATION URETER, URETERAL PELVIC JUNCTION AND RENAL PELVIS EXHIBITING NO UROTHELIAL DYSPLASIA OR MALIGNANCY RENAL PARENCHYMA, NO SIGNIFICANT HISTOPATHOLOGIC CHANGE  NO MALIGNANCY IDENTIFIED IN SIX HILAR LYMPH NODES EXAMINED (O/6) RIGHT PARACAVAL LYMPH NODES (E) : NO MALIGNANCY IDENTIFIED IN FIVE LYMPH NODES EXAMINED (O/5) RIGHT COMMON ILIAC LYMPH NODES (F) : NO MALIGNANCY IDENTIFIED IN FIVE LYMPH NODES EXAMINED (O/5) LEFT PARA AORTIC LYMPH NODES (G) :  NO MALIGNANCY IDENTIFIED IN EIGHT LYMPH NODES EXAMINED (O/8) LEFT COMMON ILIAC LYMPH NODES (H) : NO MALIGNANCY IDENTIFIED IN FOUR LYMPH NODES EXAMINED (O/4)
+
+--- Page 2 ---
+Page 2 of 6 LEFT PARA AORTIC PROXIMAL LYMPH NODES (I) : NO MALIGNANCY IDENTIFIED IN SIX LYMPH NODES EXAMINED (0/6) RIGHT LYMPH NODES OF CLOQUET (J):) NO MALIGNANCY IDENTIFIED IN THREE LYMPH NODES EXAMINED (0/3)) RIGHT EXTERNAL ILIAC LYMPH NODES (K) :  NO MALIGNANCY IDENTIFIED IN 14 LYMPH NODES EXAMINED (0/14) RIGHT OBTURATOR / HYPOGASTRIC LYMPH NODES (L) :  NO MALIGNANCY IDENTIFIED IN SIX LYMPH NODES EXAMINED (O/6) LEFT OBTURATOR / HYPOGASTRIC LYMPH NODES (M) :  NO MALIGNANCY IDENTIFIED IN FIVE LYMPH NODES EXAMINED (O/5) LEFT EXTERNAL ILIAC LYMPH NODES (N) :) NO MALIGNANCY IDENTIFIED IN THREE LYMPH NODES EXAMINED (0/3) RIGHT PRESCIATIC LYMPH NODES (O): NO MALIGNANCY IDENTIFIED IN FOUR LYMPH NODES EXAMINED (O/4)) PRESACRAL LYMPH NODES (P) :  NO MALIGNANCY IDENTIFIED IN EIGHT LYMPH NODES EXAMINED (O/8)) LEFT PRESCIATIC LYMPH NODES (Q) : NO MALIGNANCY IDENTIFIED IN TWO LYMPH NODES EXAMINED (O/2) RIGHT PROXIMAL URETER (R) :) BENIGN URETER  NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED LYMPH NODE SUMMARY: NO MALIGNANCY IDENTIFIED IN TOTAL OF 79 LYMPH NODES EXAMINED (0/79)) PATHOLOGIC TNM STAGE: BLADDER : pTisT3bNOMX PROSTATE: pT2aN0MX (AJCC-1997) COMMENT: Representative sections of invasive urothelial carcinoma are submitted for p53 assay by immunohistology, results of which will be reported separately.. SPECIMEN SOURCE: A: "Right distal ureter" B: "Apical urethral margin F/S" C: "Bladder/prostate" "Left kidney" D E: "Right para caval Lymph nodes" F: "Right common ilia lymph nodes". G: "Left para aortic lymph nodes" "Left common iliac lymph nodes". H I: "Left para aortic proximal lymph nodes"
+
+--- Page 3 ---
+Page 3 of 6 J: "Right lymph nodes of cloquet'. "Right external iliac lymph nodes" K: I: "Right obturator/hypogastric lymph nodes" M: "Left obturator/hypogastric lymph nodes". N : "Left external iliac lymph nodes" #Right pre-sciatic lymph nodes" P: "pre sacral lymph nodes" Q "Left pre-sciatic lymph nodes" R: "Right proximal ureter" CLINICAL INFORMATION: Pre-Op Dx:  bladder cancer; s/p hiatal hernia repair, TURP. GROSS EXAMINATION: A: The specimen is received fresh from the O.R. and labeled aRight distal ureter' It consists of a portion of ureter with attached fat which measures 0.4 cm in diameter by 0.6 cm long. Entirely embedded for frozen section in cassette AFs.. B: The specimen is. received fresh from the O.R. and labeled "Apical urethral. margin F/s". It consists of two strips of soft pink mucosal tiseue which together measures 1.5 x 0.5 x 0.4 cm.  Entirely submitted for frozen section diagnosis in cassette bfs. C:  The specimen is received fresh from the O.R. and labeled "bladder/prostate". It consists of a cystoprostatectomy specimen which includes bladder and prostate. Overall, the specimen measures 27.5 x 11 x 4.5 cm with a smooth, glistening, mobile peritoneum which measures 23.5 x 10 by less than 0.1 cm.  The peritoneum does not appear to be involved by tumor.. The bladder itself measures 7.4 x 5 x 3.5 cm. The specimen is palpated to reveal firmness involving the anterior bladder neck and this area is inked black on the outside as well as the entire prostate. The specimen is then opened along the anterior prostatic urethra to reveal a large, wali measuring 7.6 x 3.3 x 2.2 cm with the involved wall measuring 2 cm in maximal thickness.  The tumor approaches within less than 0.2 cm of the inked resection margin.  The tumor is split into half as the result of the opening incision. The uninvolved bladder wall~measures 1.2 cm in thickness and the rest of the bladder mucosa appears unremarkable.  Both ureterovesical junctions are identified and are. patent. The attached ureters are opened longitudinally to reveal an unremarkable mucosa.  The right ureter measures'6 cm in iength and o.s cm in circumference, and the left ureter attached to kidney measures 20 cm in length and 0.6 cm in circumference.  The seminal vesicles are palpated from the posterior side with the right seminal vesicle measuring 2 x 1 x 1 cm and the left seminal vesicle measuring 2.i x 0.7 x 0.7 cm.  The prostatic urethra appears excavated and measures 3.1 cm in length by 2.6 cm in circumference. There is'a focal area of hemorrhage in the posterior wali of the urethra which measures 0.4 x 0.3 cm and which represents a possible biopsy site. The verumontanum itself measures 0.6 x 0.5 x 0.5 cm. Representative sections of the bladder tumor and bladder are submitted in cassettes c1 to c28. The prostate is then serially sectioned from apex to base (1 through 9) to reveal gross hypertrophy of the transitional zone. Sections are submitted in cassettes c29 to c51.. D: The specimen is received fresh from the O.R. and labeled "Left kidney". It consists of a nephroureterectomy specimen which is attached to the bladder and prostate by its ureter (bladder and prostate represent part C) and overall measures 21 x 12.4 x 4 cm, including the perinephric fat. The kidney itself measures 12 x 5 x 3 cm.  The ureter attached to the bladder measures 20 cm in length and 0.6 cm in external diameter.  The kidney is bivalved and reveals unremarkable cortex and renal medullary tissue. The renal pelvis appears slightly dilated. The junction of the proximal ureter and renal pelvis is narrowed to the extent that it is difficult to open utilizing scissors. Once opened the circumference at the.
+
+--- Page 4 ---
+Page 4 of 6 narrowest point of the ureteropelvic junction is 0.4, but is otherwise unremarkable. The mucosa of the entire ureter, ureteropelvic junction and renal. pelvis appears grossly normal. No mass lesions or other mucosal abnormalities are appreciated. The opened specimen is demonstrated at this point to the surgeon.  The vascular margins including renal artery and vein are then identified with the renal artery measuring 3 cm in length by 0.5 cm in diameter and renal vein measuring 3 cm in length by 1 cm in diameter.  The renal cortex measures 1 cm in maximal thickness and. the medullary tissue 1 cm in thickness. The perirenal fat is serially sectioned but no adrenal gland is identified as well as no obvious hilar nodes. Representative sections are submitted in il cassettes. E: The specimen is received in formalin and labeled "Right para caval Lymph. nodes". It consists of a piece of soft yellow fatty tissue measuring 4 x 3 x 1 cm. No obvious lymph nodes are identified. Entirely submitted in one cassette.. F The specimen is received in formalin and labeled "Right common iliac lymph. nodes". It consists of a piece of soft yellow fatty tissue measuring 3 x 1'x 1 cm. No obvious lymph nodes are identified.  Entirely submitted in one cassette. G:  The specimen is received in formalin and labeled "Left para aortic lymph nodes". It consists of a piece of soft yellow fatty tissue measuring 2.8 x i.9 x 0.9 cm.  No obvious lymph nodes are identified. Entirely submitted in one. cassette. H: The specimen is received in formalin and labeled "Left common iliac lymph nodes".  It consists of two pieces of soft yellow fatty tissue measuring in aggregate 3.6 x 2.1 x 1.3 cm. No obvious lymph nodes are identified.. Entirely submitted in one cassette. I: The specimen is received in formalin and labeled "Left para aortic proximal. lymph nodes". It consists of a piece of soft yellow fatty tissue measuring 4 x 1 x 1 cm.  One possible lymph node is identified measuring 2.5 cm in greatest dimension. Entirely submitted in two cassettes. J: The specimen is received in formalin and labeled "Right lymph nodes of cloquet".  It consists of two pieces of soft yellow fatty tissue measuring in aggregate 2.6 x 2 x 0.6 cm. No obvious lymph nodes are identified. Entirely submitted in one cassette. K: The specimen is received in formalin and labeled "Right external iliac lymph nodes". It consists of two large pieces of soft yellow fatty tissue measuring in aggregate 6 x 3.2 x 1.4 cm. No obvious lymph nodes are identified.  Entirely submitted in three cassettes. The specimen is received in formalin and labeled "Right obturator/hypogastric L: lymph nodes". It consists of a large piece of soft yellow fatty tissue measuring 4.5 x 3.7 x 1.4 cm. No obvious lymph nodes are identified. Entirely submitted in one cassette. M: The specimen is received in formalin and labeled "Left obturator/hypogastric. lymph nodes". It consists of a large piece of soft yellow fatty tissue measuring. 6.4 x 4.1 x 1.4 cm. No obvious lymph nodes are identified. Entirely submitted in two cassettes. N: The specimen is received in formalin and labeled "Left external iliac lymph nodes". It consists of a piece of soft yellow fatty tissue measuring 4.3 x 2.6 x 2.1 cm. One possible lymph node is identified measuring 2.6 cm in greatest dimension. Entirely submitted in four cassettes. O: The specimen is received in formalin and labeled "Right pre-sciatic lymph
+
+--- Page 5 ---
+Page 5 of 6 myooabon nodes".  It consists of multiple small pieces of soft yellow fatty tissue measuring. in aggregate 2.7 x 1.9 x 0.6 cm.  No obvious lymph nodes are identified..  Entirely submitted in one cassette. P: The specimen is received in formalin and labeled "pre sacral lymph nodes". It consists of a large piece of soft yellow fatty tissue measuring 5.5 x 4 x 1.3 cm. No obvious lymph nodes are identified. Entirely submitted in three cassettes. Q:. The specimen is received in formalin and labeled nLeft pre-sciatic lymph nodes". It consists of multiple small pieces of soft yellow fatty tissue measuring in aggregate 2.1 x 1.6 x 0.5 cm. No obvious lymph nodes are identified. Entirely. submitted in one cassette. R:  The specimen is received in formalin and labeled "Right proximal ureter". 'It consists of a 0.6 cm in length and 0.4 cm in diameter portion of. ureter with attached fat which has been stapled equidistant from both ends. Both ends are. inked black.  The specimen is serially sectioned and entirely submitted in one Cassette. SECTIONS: AFS: frozen section, right distal ureter BFS: frozen section, apical urethral margin C1,2: bladder/prostate; anterior bladder wall. C3 : right ureterovesical junction C4 : right lateral bladder wall C5: dome C6: posterior bladder wall C7: ieft lateral bladder wall C8: left ureterovesical junction representing first 4 cm of the attached distal left ureter with the more proximal section inked black C9 : left ureter additional sections representing the last proximal 8 to 13 cm of the left ureter C10: trigone C11-14 : tumor on the right side of bladder neck C15-26: tumor on the left side of bladder neck C27 : right perivesical fat for possible lymph nodes C28 : left perivesical fat for possible lymph nodes C29 : distalmost prostate on the right side C30: distalmost prostate on the left side C31,32 : right midprostate (slice #4), anterior and posterior C33,34: left midprostate (slice #4), anterior and posterior C35,36: right side of proximal prostate (slice #7). anterior C37,38: right side of proximal prostate (slice #7), posterior C39,40: left side of proximal prostate (slice #7). anterior C41,42: left side of proximal prostate (slice #7), posterior C43,44: posterior C45,46: right side of additional proximal prostate, posterior C47,48: left side of additional proximal prostate on the posterior side only C49,50: left side of proximalmost prostate adjacent to tumor C51: right side of proximalmost prostate adjacent to tumor D1: left kidney; renal artery and vein margins D2-5: ureteropelvic junction - entirely submitted D6: proximal ureter D7,8: renal pelvis, including the superior, mid and lower poles D9: renal parenchyma D10,11: hilar fat for possible lymph nodes E: right paracaval lymph nodes - all embedded
+
+--- Page 6 ---
+Page 6 of 6 Ordered right common iliac lymph nodes - all embedded. G: left para-aortic lymph nodes - all embedded. H: left common iliac iymph nodes -all embedded I1: left para-aortic proximal lymph nodes; large lymph node, bisected. 12: remaining tissue J: right lymph nodes of Cloquet - all embedded. K1-3: right external iliac lymph nodes - all embedded L: right obturator/hypogastric lymph nodes - all embedded. M1,2: left obturator/hypogastric lymph nodes - all embedded N1,2: left external iliac lymph nodes; large lymph node, bisected N3,4 : remaining tissue 0: right presciatic lymph nodes - all embedded. P1-3: presacral lymph nodes - all embedded Q: left presciatic lymph nodes - all embedded R: right proximal ureter - all embedded INTRAOPERATIVE FROZEN CONSULTATION: AFS: Right distal ureter: no high grade atypia or tumor identified BFS: Apical urethral margin:  no high grade atypia or tumor identified MICROSCOPIC EXAMINATION: A-B: See final microscopic-diagnosis. C:  Sections of the bladder show multiple foci of urothelial carcinoma in situ. (flat lesion) [C2,3-5,7,8,10,11,13,14,16,18,20,21,24,26]. This includes the trigone (cio) and left ureterovesical junction (cs).  Sections of the mass around the bladder neck show a deeply invasive poorly differentiated urothelial carcinoma (C11-26). that focally involves the perivesical soft tissue (C19,25,26). Sections of the attached left ureter show focal reactive changes but no evidence of dysplasia or malignancy. No lymphovascular invasion is seen and all .resection margins are free of both urothelial dysplasia and malignancy. Sections of the prostate show unilateral prostatic adenocarcinoma (c3o,43),. Gleason's score 7 (3+4). The carcinoma is confined to the prostate without involvement of either the capsule or periprostatic soft tissue. Also seen are several foci of high grade prostatic intraepithelial neoplasia. (pIN III) [C29,34]. The prostatic urethra shows no evidence of urothelial dysplasia and no invasive urothelial carcinoma is seen in any of the sections of the prostate. Bilateral seminal vesicles show no evidence of malignancy. Resection margins are free of malignancy: D  Sections of the kidney that include the entire ureteropelvic junction, show no urothelial dysplasia or malignancy. The mucosa of the renal pelvis is. unremarkable. *Sections of renal parenchyma show no significant histopathologic change. Six renal hilar lymph nodes are identified, all of which are free of malignancy and show no significant histopathologic features. E-R:  See final microscopic-diagnosis.
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diff --git a/output/text/bf67ee96-666e-4fa0-bd2c-bc331567c88c.txt b/output/text/bf67ee96-666e-4fa0-bd2c-bc331567c88c.txt
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index 0000000000000000000000000000000000000000..503b21cb024414eeb3411b93b19c57aa4d4e3f29
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+tiobgRen SaRonsvaNor u Received Date/Time Final Reporting Information Date/Time : Final Histopathologist Laboratory : Consultant-In-Charge Final Submitting Physician Final Histopathology Report Final DIAGNOSIS Small intestine and sigmoid colon: Diffuse large. B-cell lymphoma.. Comment: The specimen shows lymphomatous involvement by diffuse large B-cell lymphoma. The phenotype is in keeping with germinal centre. B-cell (gcb) type by Hans' criteria although the expression of Foxpl and weak immunostaining for LM02 has been reported in the activated B-cell (ABC) subtype. GROSS DESCRIPTION The specimen is received in formalin, labelled with patient's data, and designated "small bowel tumour with sigmoid colon". It consists of an enblock resection of small bowel tumour mass together with adherent segments of small and large bowel..  The small bowel loops are twisted and kinked, with part of. them entrapped within the encircling tumour mass,  measuring in total approximately 70cm in length and 8cm in diameter. The tumour mass measures 15 x 14 x 9cm, located 7cm from far end and 4cm from near end of the small bowel. It has a fish-flesh pale pink appearance on cut sections. The large bowel is attached to the external surface of the tumour mass, measuring 9cm in length and 4.5cm in circumference. The mucosa of the bowel appears unremarkable. The external surface of the tumour is inked blue..  Also received a piece of cross stapled bowel measuring 6 x 3.5 x 1cm.. No discrete lesions are seen. No definite lymph nodes are identified in this specimen.. (Al-far margin of small bowel, A2-near margin of small bowel, A3&A4-shaved margins of large bowel, A5 to A8-tumo!.  with entrapped small bowel,. A9&A10-tumour with adjacent mucosa) MICROSCOPIC DESCRIPTION Sections show a transmural lymphomatous infiltrate in the small intestine, featuring a diffuse infiltrate of large lymphoid cells with scattered tingible body macrophages, imparting a focally 'starry sky' appearance. Neoplastic cells. display vesicular chromatin, moderate nuclear pleomorphism, prominent nucleoli and scattered mitoses. Immunohistochemistry confirms the neoplastic lymphoid cells to be of B-cell lineage with expression of cD20 and pax5. They co-express. germinal centre markers cD10, bcl6 and heterogeneous staining for Lmo2. At the same time there is also weak and heterogeneous expression of muml, as well as strong immunoreactivity for FoxPl. No residual follicular dendritic meshworks are seen with immunostaining for cd2l. The proliferation fraction is high at >90% and there is strong expression of the anti-apoptotic molecule bcl2 in most. tumour cells, thereby excluding Burkitt lymphoma. Immunohistochemical stains with cD2o and pAx5 demonstrate scattered small B lymphocytes and cD3 stains T lymphocytes. No marked expansion of these cells are seen
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diff --git a/output/text/bfbdc2be-28fd-4e0c-82ee-a5fd6c9a9348.txt b/output/text/bfbdc2be-28fd-4e0c-82ee-a5fd6c9a9348.txt
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index 0000000000000000000000000000000000000000..0fbb52687dd5e70e306d3f5377d9c78c45c38e40
--- /dev/null
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+P.25/33 SAL DIAGNOSIS: Breast, Right, modified radical mastectomy --  Invasive Ductal caRcinoma with Associated calcifications. A. B.  NOtTinghAm GrADe 3 (tuBuLe fORmatiOn: 3, nucLear pLeOmOrphIsm: 3. miTOTIC ActivIty: 3; tOtAl SCORE: 9/9) C. INVASIVE TUmOR MEASURES 2.5 X 2.3 X 2.0 Cm. D. DUctal CArcinoma In Situ (DCiS), nucLEAr GraDe 3, SOLiD, CRiBrIFOrm mICROpapILLARy And CLEaR CELl TYPEs WITH COMeDONECROSIS AND ASSOCiaTeD CALCIFIcATIOnS. E. THe Ductal CArcinoma in Situ (DciS) COnstitutes 50% Of the TOtal TumOr VOLume AnD iS PrEsent ADmIXeD wIth The inVAsive COmpOneNT. F. The Ductal Carcinoma in situ (Dcis) is present in 12i22 sLiDes. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED. H. RESECTION MARGINS ARE NEGATIVE FOR CARCINOMA. DUCTAL CARCINOMA IN SITU (DCIS) IS 4.O MM FROM THe nEAREST AnTeRIOR mARGiN. The InVASIVe CARCInOMA iS GREATER THAn 1.0 Cm FrOm ALL MARGINS. I. THe nIpple is InvoLVed By Ductal CArcinoma In sitU. J. SKIn IS nEGative fOR TumOR. K. NOn-neOpLASTIC bREAST: iNTraDUcTaL PAPiLLOmA AnD FiBROCySTic CHAngeS WiTH FIBROADENOmATOID NODULES. Biopsy sIte Changes wIth fat necrOsIS. M. METASTATiC CARCINOMA INVOLVING FOUR OF TWENTY-SiX LYMPH NODES (4I26). N. THE LARGEST METASTATIC FOCUS MEASURES 2.0 CM. O. EXTRACAPSULAR ExTeNSIOn IS IDENTIfIeD AnD MEA$URES 1 MM. P. THE iNVASIVE TUMOR CELLS TESTED POSITIVE fOR ESTROGEN AND WEAKLY POSITIVE fOR PROgesterOne receptOrs And negAtive fOr hER-2, As per PrevIOUs PaThOLOgy rEpOrt CASE SYNOPSIS: SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST LATERALITy: Right PROCEDUrE: Modified radical mastectomy LOCATION: Lower outer quadrant Size of tumor: Maximum dimension invasive cornponent: 2 5 cn MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: No TUMOR TYPE (invasive component): 1cs-0-3 Ductal adenocarcinoma, No  NOtTinGham scOre: earcmomu,nifiltratny ductd, nos 85esf3 Nuclear grade: 3 Tubulc forrnation: 3 Site: Srast, Nos C50.9 31r|n p Mitolic actlvity score: 3 Total Notungham score: 9 Nottingham grade (1. 2, 3): 3 ANGIOLYmPHATIC INVASION: UUID: 29EDE507-90BA-4ABE-B3EF-559EBA4CCD56 Yes TCGA-BH-A0E2-01A-PR Redacted DeRmaL. Lymphatic invAsion: No CALcifIcAtIOn: Yes, malignant zones Tumor type, in situ: Cribriform Solid Micropapillary Comedo DCIS admixed with invasive carcinoma Percent of tunor occupled by in situ componen! 50 %. SURGICAL MARGINS INVOLVED BY iNVASIVE COMPONENT: No SURG MArGINs InVOLVeD by in SItU cOMpONeNT: No Distance of in silu disease to closest margin: 4 0 rmm PAget's DISEASE OF nIPPLE: No LympH nOdES POsItIvE: 4 LYMPH NODES EXAMiNED: 26 MEthOD(S) Of Lymph nODE EXAmInATIOn: H/E levels SIZE OF NODAL METASTASES: Djumeter of largest lymph nodo metastasis: 20 mm LYmPH nODE METASTASIS(-ES) WITH EXTRACAPSULAR EXTENSION: Yes SKIN INVOLVED (ULCERATION): No NON-NEOPLASTiC BREAST TIssUE: Papilionia, FCD, Other: Fitroadenomatoid nodules. t stage, pathologiC: pT2. , N stage, pathologic: :pN2a m Stage, pathologic: pMX: Estrogen receptors:  positive PROGeSTeRONe rEcepTOrs: .positive HER2/NEU: FIED W..zeroror+.
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diff --git a/output/text/c0015b76-bdd7-476a-8b43-9a1013b9176d.txt b/output/text/c0015b76-bdd7-476a-8b43-9a1013b9176d.txt
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index 0000000000000000000000000000000000000000..1c737e6a7190c08af09a292d60e3fd48200c1c75
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+I@D-3 acted Reda lderdcare.uusmo ductNsS 85C|3 Site; Pneeao Nos CQ5.9 J>c/5liy Age:  male Surgery date: Macroscopy 1. Resection of the pancreas: unfixed, 4.5x3.5x0.7 cm large lamellae of the pancreas. The tissue is grey- yellowish, fibrotic, focally diffuse indurated. The ductus pancreaticus is rather centrally oriented, max. 0.4 cm in diameter, slightly ectatic. The lamellae was cut in two halves and completely used for instantaneous section after removal of the clamping and cord material. 2. Lymph node ligamentum hepatoduodenale: fixed, several max. 2 cm large lymph nodes, the largest of. which with solid grey-white cutting area.. 3. Lymph node truncus coeliacus: fixed, 2.5 cm large focally indurated lamellae of fatty tissue. Materia! was embedded completely. 4. Pancreas and spleen, additional resection specimen of the pancreas: fixed, Whipple resection specimen in two parts with a 13x6x5 cm large pancreas, 15 cm long duodenum, and a 5 cm long ductus choledochus. Peripancreatic tissue max. 1.5 cm wide. Almost the complete pancreas is captured by a 12x5x4 cm large, relatively clear defined solid tumor with mostly solid white-yellowish cutting area. (tumor diameter of the first resected Whipple specimen was 6 cm, tumor diameter of the additional resection specimen of the tail was also 6 cm). At the cranial part of the tumor a 2.2. cm cyst. Wide. infiltration of the peripancreatic soft tissue and the lamina muscularis of the duodenum. The tumor is. not discernable dorsal from the resection margin of the pancreas. Peripancreatically several max. 2.2 cm. dense lymph nodes with solid grey-white cutting area. Distance of the resection margin of the ductus. choledochus 5 cm, to the resection margin of the duodenum oral 2 cm, to the aboral resection margin 10 cm. At the processus uncinatus regular lobular pancreatic parenchyma. Spleen weight 110 grams and 11x7x5 cm large focus. Ink mark: black resection margin dorsal, blue resection margin ventral. Attached is a 8x8x1 cm large omentum without tumor. Photo documentation. A. Tumor at the head of the pancreas/duodenum B. Tumor at the head of the pancreas/cyst c. Tumor/regular pancreatic parenchyma (processus unicinatus) D. Tumor/ductus choledochus. E. Tumor/resection margin dorsal/vessels (pancreas corpus) F. Tumor/resection margin ventral (tail of the pancreas) G.-J. Lymph nodes. K. Resection margin bile duct, resection margin duodenum oral L. Resection margin duodenum aboral. M. Speen and omentum Instantaneous section report:. 1. Positive malignancy, focally invasive carcinoma infiltrates, alongside extended high grade PanIN lesions (IPMN) (characterization after fixation)
+
+--- Page 2 ---
+Processed: 2 x instantaneous sections, 16 blocks, H&E, 2x EvG, 2xFe, 1x PAS, 2x complex macroscopy Microscopy 1. There are infiltrates of a mostly ductal adenocarcinoma. Focally the infiltrates extend to the adjacent. parapancreatic fatty tissue. Occasionally perineural growth. Focally high grade PaniN. In the vicinity. much desmoplastic reaction. Focally polarization-optically double defracted surgical thread. 2. detection of a lymph node metastasis of max. 2 cm in diameter (obviously intranodal) out of 2 total. lymph nodes. 3. Detection of 5 lymph nodes without tumor and atypical cell complexes (probably contaminating) 4. The macroscopically described tumor is composed of infiltrates of a mostly ductal and focally solid growing carcinoma. The tumor cells sometimes with bright cytoplasm. Moderately differentiated and focally high grade nuclear pleomorphia and distortion of the nucleus-cytoplasm relation and formation. of promiment nucleoli. The tumor cells partially infiltrate the tunica mucularis of the duodenum and up. to the submucosa. Here vessel invasion is seen. In addition, there is extended infiltration of the peripancreatic fatty tissue all the way up to the vessel containing fatty tissue. The tumor infiltrates. extend to the dorsal resection margin. In the adjacent pancreatic parenchyma there are some PanIN lesions. Detection of 5 lymph node metastases out of 14 lymph nodes. The resection margins of the small intestine and the ductus choledochus are without tumor. Spleen parenchyma without tumor and indication of chronic congestion. Short report on diagnostic findings Invasive, moderately differentiated ductal adenocarcinoma of the pancreas, reaching from the head of the pancreas to the tail, max. 12 cm in diameter (1., 4.). Wide infiltration of the peripancreatic fatty tissue (1., 4.) and infiltration of the submucosa of the small intestine (4.) and focally infiltration of the tissue of the truncus coeliacus (3.). The dorsal resection margin and the resection at the truncus coeliacus took not place in the healthy tissue (3.). Detection of lymphovasular infiltration and extended perineural growth. Detection of 6 lymph node metastases out of 21 lymph nodes (2., 3., 4.) Resection margin from the ductus choledochus from small intestine and aboral without tumor and. spleen without tumor (4.). UlCC, 6th Edition 2002: pT4, pN1 (6/21), L1, V1, Pn1 Resection status: R1 (resection margin dorsal and at the truncus coeliacus) Grading: G2 bw i13if1y
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diff --git a/output/text/c00bace6-4131-437b-93ce-05288402f44e.txt b/output/text/c00bace6-4131-437b-93ce-05288402f44e.txt
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index 0000000000000000000000000000000000000000..a0ba0f272bde18cfa33cd1a8f97adb1676b44091
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+UUID:E62609FC-BB2B-482F-A3C8-902827682D190 Department of Pathology TCGA-P4-A5E8-01A-PR Redacted Tissue Source Site (Tss) # Patholgy Accession No: Patient ID: Normal Sample ID: Pathology Report ICD-O-3 DIAGNOSIS (A) LEFT KIDNEY WITH REGIONAL LYMPH NODES:E Circnorro, pp)lany PAPILLARY RENAL CELL CARCINOMA (10.0 CM MAXIMUM DIMENSION), FUHRMAN 826613 renal cel NUCLEAR GRADE 3, WITH VASCULAR-LYMPHATIC INVASION, CONFINED TO THE KIDNEY. (SEE COMMENT) Site: CKidney NDS Margins of resection free of tumor. 649 Adrenal gland, no tumor present.. METASTATIC PAPILLARY RENAL CELL CARCINOMA IN THREE OF THREE LYMPH NODES. (B) PARA-AORTIC LYMPH NODES: METASTATIC PAPILLARY RENAL CELL CARCINOMA IN MATTED LYMPH NODES (SEE COMMENT) COMMENT The papillary renal cell carcinoma is composed of papillae lined by tall columnar cells. Most tumor cells have eosinophilic cytoplasm, and some cells have clear cytoplasm. These morphologic features are consistent with type 2 papillary renal cell carcinoma. The tumor appears to be confined to the kidney and does not show invasion into the renal sinus adipose tissue, perinephric fat or the renal vein. The para-aortic lymph nodes (specimen B) involved by metastatic renal cell carcinoma are matted together, hence the exact number of lymph nodes cannot be assessed. In addition to tumor in the lymph nodes there are small foci of tumor within vascular. lymphatic spaces in the perinodal adipose tissue.. GROSS DESCRIPTION (A) LEFT KIDNEY WITH REGIONAL LYMPH NODE, VACCiNE PROTOCOL - A radical nephrectomy specimen (21.0 x 15.0 x 8.5 cm) including the left kidney (12.5 x 11.0 x 7.3 cm), a segment of renal artery, the renal vein and ureter (1.4 cm in length and 0.5 cm average diameter) and the adrenal gland (5.5 x 2.0 x 1.4 cm). There is a 10.0 x 8.5 x 8.5 cm well circumscribed tumor in the lower/mid pole of the kidney. The tumor is tan-gray and friable with focal areas of hemorrhage and necrosis throughout. The tumor is well circumscribed and does not grossly invade into perinephric adipose tissue, renal sinus, or renal vein. The tumor does not extend to Gerota's fascia. Three enlarged lymph nodes (0.6 to 2.9 cm in greatest dimension) are identified in the hilum of the kidney. These are grossly involved by tumor. The adjacent kidney parenchyma is unremarkable. The pelvicalyceal system is smooth and devoid of any lesions. Serial cross sections of the left adrenal gland show unremarkable cortex and medulla. Tumor has been submitted for the vaccine protocol. Portions of the tumor have also been submitted for possible electron microscopy. Photographs were obtained. INK CODE: Blue - Gerota's fascia. SECTiON CODE: A1, renal vein, renal artery, and ureter margins; A2, adrenal gland, representative sections; A3, tumor with nearest soft tissue margin; A4-A6, tumor and adjacent uninvolved kidney; A7, A8, tumor and renal sinus; A9-A12, representative sections of tumor; A13, one hilar lymph node, representative section; A14, one hilar lymph node, representative section; A15, one hilar lymph node bisected. (B) PARA-AORTIC LYMPH NODE - Three irregular fragments of soft tissue (8.0 x 5.0 x 3.0 cm in aggregate). On cut surface it appears to be a matted aggregate of variegated white-yellow-red tumor. No residual lymph node tissue is grossly identified. Representative sections submitted in B1-B5. CLINICAL HISTORY None given. SNOMED CODES T-71000, M-83123, M-Y1593, T-C4400, M-83126, M-Y1596
+
+--- Page 2 ---
+Department of Pathology. Tissue Source Site (TSS) #: Patholgy Accession No: Patient ID: Normal Sample iD: : Tumor Sample ID: "Some tests reported here may have been developed and performance characteristics determined by These tests have not been specifically cleared or approved by. the U.S. Food and Drug Administration.". 2
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diff --git a/output/text/c0561d62-489a-4ab1-b2f7-edf0ab8a87c3.txt b/output/text/c0561d62-489a-4ab1-b2f7-edf0ab8a87c3.txt
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index 0000000000000000000000000000000000000000..2ca20333643e47eda9dc2ff2af6efcd605f4b120
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+ica~0- 3 8500/3 Carciomn, h~fit+rung duct, Nos C509 Srte Codi : breurt, Nos 12f2:J1v h Final Diagnosis Breast, left, wide local excision: Infiltrating ductal carcinoma, Nottingham grade II (of III). [tubules 3/3, nuclei 2/3, mitoses 2/3; Nottingham score 7/9], forming a mass (1.9 x 1.8 x 1.2 cm) [AJCC pT1c]. Ductal carcinoma in situ, intermediate nuclear grade, comprises approximately 5- 25% of tumor volume (including the ductal carcinoma in situ, the tumor is 2.1 cm, in greatest dimension). Angiolymphatic invasion is absent. The non-neoplastic breast parenchyma shows proliferative fibrocystic changes. All surgical resection margins, including the separately. submitted re-excision of the medial margin, are negative for tumor (minimum tumor free margin, 0.5 cm, deep and inferior margin). Lymph nodes, left axillary sentinel, excision: Multiple (8) left axillary sentinel lymph nodes are negative for metastatic carcinoma [AJCC pN0 (i-) ()]. Immunohistochemical cytokeratin stain was performed on the paraffin embedded sentinel lymph node tissue and confirms the H&E impression.. UUID:4FDBA110-6E14-428C-BF82-168AE28A14E4  Redacted TCGA-AR-A1AX-01A-PR ry Turnor Site D
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diff --git a/output/text/c0ab451a-50b9-4f8d-8cd0-a87eabd83a4b.txt b/output/text/c0ab451a-50b9-4f8d-8cd0-a87eabd83a4b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..80ed160bbcfdc2e05f0de757546cedf9c6c741ef
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+IQD c 3 8q60f3 Operative Procedure: Sit @Kiny NcS. Right laparoscopic nephrectomy C649 3|3|4 Specimen Received: Right kidney Final Pathologic Diagnosis: UUID:9E443ECF-C8CE-4AB7-ACF6-D64C50F661BC Kidney, right, laparoscopic nephrectomy. Redacted Tumor histologic type: Papillary renal cell carcinoma, type 2. Sarcomatoid features (%):  Not identified Tumor size: 4.8 cm (greatest dimension) Other dimensions: 3.7 x 3.5 cm Macroscopic extent of tumor: Confined to the kidney Focality: Unifocal Number of tumors: 1 Fuhrman grade: 3 of 4 Microscopic extent of tumor: Perinephric fat invasion: No Renal sinus invasion: No Other: Not identified Renal vein involvement:  No Adrenal gland present: No (If yes) Involved by tumor:  Not applicable (If yes) Direct invasion or metastasis:. Not applicable Cancer at resection margin: No (If yes) Location(s): Not applicable Pathologic findings in nonneoplastic kidney: Renal cortical cyst  Renomedullary interstitial cell tumor. Hilar lymph nodes present: Not identified (If yes) Number involved/number present:  Not applicable Pathologic stage (2010) pT1b pNx pM-not applicable The examination of this case material and the preparation of this report were performed by the staff pathologist. Gross Description: The specimen is received in formalin labeled with the patient name and additionally labeled, "right kidney' and consists of a kidney received with abundant perinephric fibroadipose tissue. The kidney has dimension of 11.5 x 7 x 5 cm. The attached ureter has a length of 5 cm and diameter of 0.4 cm. The specimen is received partially inked and partially incised. Sectioning through the specimen reveals a tan-brown, lobulated, fairly well-delineated mass in the mid portion of the kidney that has dimensions of 4.8 x 3.7 x 3.5 cm. This mass involves the renal sinus fat, focally abuts the wall at the renal vein and
+
+--- Page 2 ---
+focally extends to the renal capsule. The mass does not appear to extend beyond the renal capsule. The mass has a hemorrhagic, degenerative cut surface. A portion of the mass has been submitted to the Tissue Bank. Adjacent to. the mass is a cortical cyst that is 0.8 cm in greatest dimension that contains tan-brown fluid. The cyst lining is predominately smooth. There is a tan-white,n. well-delineated nodule that is 1.2 cm from the mass that has dimensions of 0.3 x 0.2 x 0.2 cm. The remaining, uninvolved renal parenchyma is pink-tan to. red-brown with a fairly well-delineated corticomedullary junction. The thickness of the cortex is up to 1.2 cm. The collecting system is lined by pink-tan,. granular mucosa. The capsule strips with some difficulty revealing a red-brown. to pink-tan, nodular surface.. The hilar fat is removed and has a weight of 15 g. Sectioning reveals no. definitive lymph nodes. Representative sections are submitted as follows:. 1  hilar margins en face; 2,3  mass to inked external surface;. 4 mass to capsule; 5 mass to renal sinus fat; 6  mass to renal sinus fat and wall of renal vein; 7 mass to uninvolved kidney; 8 cortical cyst adjacent to mass;. 9  well-delineated nodule adjacent to mass;. 10 uninvolved renal parenchyma; 11,12 hilar fat for possible lymph node capture.. Please note, multiple gross photographs are taken. Aiso there is no adrena! gland present. Microscopic Description: The final diagnosis of each specimen incorporates the microscopic examination findings. END OF REPORT Surgical Pathology Report Taken: DOB: Age: Gender: M W 13//13
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diff --git a/output/text/c0dbb96d-be76-41bb-834f-7747bb0d7a5b.txt b/output/text/c0dbb96d-be76-41bb-834f-7747bb0d7a5b.txt
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index 0000000000000000000000000000000000000000..69d11a0bd8cefcf332b889a0498a27271b3d2978
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+*** Diagnosis / Diagnoses: *** 1.: Adnexa (right) with a serous cystadenofibroma of the ovary, measuring 8 cm in. diameter. Tube without relevant pathological findings.. 2. (right hemicolectomy specimen) with an ulcerated colon carcinoma conforming to the histological type of a moderately differentiated colorectal adenocarcinoma, located 6 cm aboral to Bauhin's valve and with a greatest diameter of 3 cm. Invasive spread of tumor. within all layers of the intestinal wall and as far as the neighboring fatty tissue. Appendix without relevant pathological findings.. Oral and aboral resection margins and large omentum tumor-free. Twenty regional lymph nodes tumor-free with uncharacteristic reactive changes. Tumor stage thus pT3 pN0 (0/20) L0, V0; G2
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diff --git a/output/text/c0f85c2b-a905-494e-9288-d9ff8d7b4ae9.txt b/output/text/c0f85c2b-a905-494e-9288-d9ff8d7b4ae9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d3f4021c244108a7a13fc615d34b0f73a04adcc5
--- /dev/null
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+1cs-0 - 3 . Cacinons, Infi(t^nting 1rbulu,Nos 85oof_3 Srh lrdu: brot, isos c50.9 1/7f1 Patient lre Surgical Pathology: Surg Path UUID:6C91D49C-9738-4A4F-A480-E71CD8EE52680 TCGA-B6-A0IP-01A-Pr Redacted CLINICAL HISTORY: Left breast Ca. Left breast mass. GROSS EXAMINATION: "Left breast mass (AF1)", received fresh for frozen section. A 7.3 x 4.4 x A.. 2.5 cm ovoid fragment of soft yellow fibroadipose which has been previously sectioned revealing a 1.7 x approximately 1.6 x 1.4 cm firm stellate circumscribed yellow-tan mass. The surgeon has stated the margins are not an issue on this specimen the mastectomy is to be performed. A portion of the lesion has been previously submitted as frozen section AFl. Fresh tissue for ER/pR was not submitted. The remainder of the specimen composed of soft yellow lobulated adipose tissue without additional focal lesions.. BLOCK SUMMARY: Al- frozen section AFl remnant.. A2- additional section of mass. A3-A4- additional tissue in the area of lesion. A5-- representative of the remainder fibroadipose tissue.. B. "Left breast", received fresh and placed in formalin. A 701.6 gram, 35 x 18.3 x 3.0 cm left breast and axillary dissection is received. The breast is 21.1 x 18.3 x 3.0 cm in greatest dimension and the axilla is 7.5 x 6.5 x 1.5 cm in greatest dimension. The overlying ellipse of white skin is 19 x 8.2 cm in greatest dimension. The nipple is located slightly inferior and medial on the skin surface and is retracted and exhibits a crusted skin surface and is approximately 1 cm in greatest diameter with a 3.5 cm areola. Superior to the. nipple is a 7.5 cm long recent linear suture surgical incision. The surgical margin is marked with blue ink and the specimen is sectioned revealing a fresh biopsy cavity, approximately 7.5 x 6.5 x 6 cm in greatest dimension lined by soft hemorrhagic adipose tissue. The biopsy cavity is grossly within 0.5 cm with closest deep surgical margin, 12.5 cm with the closest inferior soft tissue surgical margin. The tumor does not grossly identified within the specimen. The remainder of the breast tissue is composed of soft lobulated fibroadipose tissue with only small amount of pink-tan fibrous breast tissue. BLOCK SUMMARY: B1- nipple. B2- representative through incision on skin surface.. B3- biopsy cavity in closest deep margin. B4-B5- additional sections of biopsy cavity wall. B6- closest superior soft tissue margin. B7- closest inferior soft tissue margin. B8- representative upper inner quadrant. B9- representative lower inner quadrant. B10-representative lower outer quadrant. Bll- representative upper outer quadrant. The axillary dissection is removed from the mastectomy specimen, divided into. proximal, mid, and distal thirds and examined for lymph nodes. Several lymph node candidates from 0.5 to 3.2 cm are identified, predominantly in the distal third of the specimen. Lymph nodes are submitted as follows:. B12- one lymph node candidate from proximal. B13- one bisected lymph node candidate from proximal..  B14- one lymph node candidate from mid. B15- one bisected lymph node candidate from mid. 1 of 3
+
+--- Page 2 ---
+B16- five lymph node lymph node candidates from distal.. B17- three lymph node candidates from distal. B18- one bisected lymph node candidate from distal.. B19- one bisected lymph node candidate from distal.. B20- one bisected lymph node candidate. INTRA OPERATIVE CONSULTATION: A. "Left breast biopsy": AF1- (infiltrating lobular carcinoma) (Dr. DIAGNOSIS: A. "LEFT BREAST MASS" (EXCISIONAL BIOPSY) : INFILTRATING CARCINOMA,. LOBULAR TYPE. GROSS TUMOR SIZE, 1.7 X 1.6 X 1.4 CM (GROSSLY). SIZE OF INVASIVE COMPONENT 1.7 CM. LYMPHATIC/VASCULAR INVASION: ABSENT. MULTIFOCAL TUMOR: NO. IN SITU CARCINOMA PRESENT, OCCUPYING LESS THAN 5% OF TUMOR (SLIDE A-2, A-4) TYPE OF IN SITU CARCINOMA: LOBULAR TYPE. EXTENSIVE INTRADUCTAL COMPONENT: NO STATUS OF NON-NEOPLASTIC BREAST TISSUE INCLUDES PROLIFERATIVE FIBROCYSTIC CHANGES WITH ATYPIA, INTRADUCTAL PAPILLOMA (SLIDE A-3) MICROCALCIFICATION PRESENT IN ASSOCIATION WITH BENIGN BREAST TISSUE. SURGICAL MARGIN STATUS: (SEE COMMENT) ESTROGEN/PROGESTERONE RECEPTOR AND CELL CYCLE ANALYSIS PENDING. B. "LEFT BREAST WITH AXILLARY DISSECTION", (REMOVAL): RESIDUAL INFILTRATING AND IN-SITU CARCINOMA: ABSENT. STATUS OF NON-NEOPLASTIC BREAST TISSUE: INTRADUCTAL PAPILLOMA, ATYPICAL DUCTAL HYPERPLASIA. MICROCALCIFICATIONS PRESENT IN ASSOCIATION WITH ATYPICAL DUCTAL HYPERPLASIA. NIPPLE STATUS: FREE OF TUMOR. SKIN STATUS: FREE OF TUMOR. MUSCLE STATUS:  NOT SAMPLED. SURGICAL MARGIN STATUS: NEGATIVE. LYMPH NODE STATUS: NO EVIDENCE OF MALIGNANCY IN 16 LEFT AXILLARY LYMPH NODES, (0/16). cOMMenr: The surgical margin of the biopsy specimen was not evaluated, as the mastectomy was performed during the same procedure, per conversation with the surgeon. The resection margins of the mastectomy specimen are negative for. tumor. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es).. Electronically sigrs ADDENDUM 1: Tissue was sent to the. for assay of the estrogen and progesterone receptors. The estrogen receptor activity was judged to be pOsirivE with an estimated FMOL value of 154. The progesterone receptor. activity was judged as pOsirivE with an estimated FMoL value of 106. Please refer to for a complete report. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es).. 2 of 3
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diff --git a/output/text/c0f965cf-170b-4128-8128-043e64c2003b.txt b/output/text/c0f965cf-170b-4128-8128-043e64c2003b.txt
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index 0000000000000000000000000000000000000000..87f2b9c1ba6306a6a5ac86729345bfbefd647cbb
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+IcD-0- LWU I bpftnutmy ductaL,Nos 85o0/3 Cerunomn, Material Bot, Nos Submitted:  left breast. c50.9 Clinical History: Clinical Diagnosis: UUID:6E169005-180B-42C5-9CDC-F6699FAB5AB5 Operating TCGA-B6-A0RS-01A-PR Redacted Surgeon: Patholoav Number Gross Examination: Received is a container labeled with the patient's name, history number and date. In addition the container is labeled "left breast". The specimen is received in the fresh state and consists of a breast and attached axillary tail weighing 560 grams and measuring 37.0 x 17.5 x 3.0 em. in greatest dimension. The overlying skin ellipse measures 13.5 cm. in length with a maximum diameter of 7.0 cm. The skin is notable for a large bruise in the lower outer quadrant extending from the areola to the skin edge measuring 3.0 x 1.5 cm. in greatest dimensions.: The skin is otherwise unremarkable. Palpation reveals a 2.5 x 2.0 x 2.5 em. firm nodule adjacent to the nipple at the intersection of the upper and lower inner quadrants. The pectoralis fascia has been previously inked with Alcian blue and two Iongitudinal incisions made parallel to the long axis cf the specimen each measuring 9.5 em. in length. The firm area extends to a point 1.2 cm. from the deep surgical margin. Seetions will be submitted in the following block order. Bloek I - firm area to include deep margin.. Block II - additiona firm a.'ea to include deep margin.. Block Ill - additional firm area to include deep margin. Block iV - skin adjacent to firm area. Bloek V - mid nipple.. Block Vi - representative section from upper outer guadrant.. Block vil - representative section from lower outer quadrant. Block vill - representative section from lower inner quadrant. Block iX - representative section from upper inner quadrant.. Block X - Iymph nodes zone I. Block XI - lympn nodes zone II. Biock XII - Iymph nodes zone III. Block Xill - additional Iymph nodes zone III.. DIACINOSS: "LEFT" BREAST, MASTECTOMY: A. iNFILTRATINC DUCTAL. CARCINOMA (2.5 X 2.0 X 2.5 CM.), N.S.A.B.P. NUCLEAR GRADE POORLY DIFFERENTIATED, HISTOLOGIC GRADE 3 OF 3. B. NO CARCINOMA IDINTIFIED IN SURGICAL MARGINS. C. FIBROCYSTIC CHANGES: I. FOCAL MODERATE EPITHELIAL HYPERPLASIA. 2. SMALL CYSTS. 3. APOCRINE METAPLASIA. 4. FIBROSIS. "L.EFT" AXILI.ARY DISSECTION: NO CARCINOMA IDENTIFIED IN 15 I.ympl nonis.
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diff --git a/output/text/c1067a08-4b57-4128-9f52-968d2e3a041b.txt b/output/text/c1067a08-4b57-4128-9f52-968d2e3a041b.txt
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index 0000000000000000000000000000000000000000..a1089ff71de5ae5b5ff2497724b14541334c4dd7
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+page 1 / 2 Department of Cancer Pathology copy No. Date: Examination: Histopathological examination.  Internal invoice No. Cost of diagnostic procedure Examination No.: Patient: xxx PeseL: XXx Age: Gender: F Material: Multiple organ resection -- left breast with axillary tissues. jcs-6-3 Unit in charge: Carcinomr, nifi(tratng lobulu,nos 8520jj  Physician in charge: Sih; buast, nos c5U.9 4/1311 Material collected on:. Material received on:. Expected time of examination: up to 8 working days. Clinical diagnosis: Cancer of the left breast. Examination performed on: Macroscopic description: Left breast sized 22.4 x 17.8 x 6.4 cm removed along with axillary tissues sized 12 x 5 x 3 cm and a skin flap of 24.2 x 11.3 cm.. Weight 950 g. Tumour sized 2.7 x 1.4 x 2.8 cm found in the central part, removed 6.0 cm from the lower boundary, 0.3 cm from the base and 1.4 cm from the skin. Microscopic description:  Carcinoma lobulare invasivum (classical type, partly solid) multifocale - NHG2 (3+2+1/0 mitoses/10 HPF - visual area 0.55mm). Infiltratio carcinomatosa mamillae.  In situ lesions of the type pagetoid spread and hyperplasia within the foci of adenosis sclerosans. Glandular tissue. showing lesions of the type fibrosa et cystica, adenosis sclerosans. AxILLARY LYMPH NODEs: Metastases carcinomatosae in lymphonodis (No IX/xI). Test result: Carcinoma lobulare mixtum invasivum mammae sinistrae. Metastases carcinomatosae in lymphonodis axillae (No Ix/xI) (NHG2, pTIc, pN2a). Compliance validated by: Examination performed or : Results of immunohistochemical examination: Estrogen receptors found in over 75% of neoplastic cell nuclei. Progesterone receptors found in over 75% of neoplastic cell nuclei. HER2 protein stained with HercepTestTM by DAKO. Score = 2+. FISH verification recommended Compliance validated by: 1 Examination performed on: UUID: 5F1C3885-5E5C-4288-8779-3A5878DCE1F2 TCGA-D8-A1X8-01A-PR Redacted
+
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+page 2 / 2 Examination: Histopathological examination Examination No.: PESEL:XXX Gender: F Patient: xxx Examination performed on: Histopathological diagnosis: Carcinoma lobulare invasivum mammae sinistrae. Invasive lobular carcinoma of the left breast Metastases in Iymphonodis axillae (No IX/xl) (NHG2, pTlc, pN2a). Cancer metastases in axillary lymph nodes (No IX/xI) (NHG2, pTlc, pN2a). Compliance validated by: Examination performed on Results of immunohistochemical examination:  RESULT OF HER2/neu GENE AMPLIFICATION with the FISH method by Path Vysion HER2 DNA Probe Kit FINAL RESULT: HER-2 GENE AMPLIFICATION NOT FOUND Compliance validated by: CONTACT YOUR DOCTOR WITH THIS REPORT!
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diff --git a/output/text/c116b9bd-0996-4578-a7cb-b463860c83a2.txt b/output/text/c116b9bd-0996-4578-a7cb-b463860c83a2.txt
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index 0000000000000000000000000000000000000000..0723856b14d6b9e8bfbe886dbe902f2c5c04e999
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+/Cs-0-3 Carcinoma, infiltnatng ouctel, Nos 8500f3 Sit, breast, Nos C50.9 1/28/11 Pathology Form Specimen Information Collected by: Date Preserved by: Date: nnSPECIMEN TYPE (#ofsamples provided)W Frozen Paraffin Block  Blood/Serum/Plasma Slide Diseased Normal Diseased Normal Diseased Normal Diseased Normal H 2 2. 2 Time to LN2 Time to Formalin Time to LN2 min /2 min min SMWANTSPATHOLOGICAEDESCRIPTIONARSK* Primary Tumor Organ Size Extension of Tumor Distance to NAT Breasf Wmey. 5x4x3 cm Bj gGF hBeeg 6 cm Lymph Nodes Location # Examined # Metastasized Distant Metastasis Organ Detailed Location Size Pathological Staging pT 2. N m 0 Stage: 1 Notes: UUID: 898312D1-9FDD-4756-9C15-5442B428F75A Redacted TCGA-C8-A12Z-01A-PR 4
+
+--- Page 2 ---
+Microscopic Description wwww.wHistologicalPattenw.w.ww.. Cell Distribution + Structural Pattern Diffuse  Streaming .Mosaic Storiform  Necrosis Fibrosis Palisading Lymphocytic Infiltration Vascular Invasion Cystic Degeneration Clusterized Bleeding  Alveolar Formation  Myxoid Change  Indian File  Psammoma/Calcification CellularDifferentiation  Squamous Adenomatous + Sarcomatous + Lymphomatous + Y  Round Cell  Large Cell  Squamoid Cell Glandular cell  Fibroblast Small Cell Spindle Celi Cell Stratification Osteoblast  RS Cell/RS Like  Keratin Secretion  Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell Myoblast Plasma Cell Peart Gland formation  Poor Cellular Differentiation:. Well Moderate  Nuclear.Appearancekaew 0 1 II III Nuclear Atypia:  Aniso Nucleosis  Hyperchromatism Nucleolar Prominent x Multinucleated Giant Cell  Mitotic Activity Nuclear Grade: wrHeData. Result Value Date Marker ER  Negative  Positive PR Negative Positive Her-2/neu  Negative  Positive  Negative  Positive B-Cell Marker  Negative  Positive T-Cell Marker  Negative   Positive Other: Other: Negative Positive Final Pathology Report Fra7irb cluc Tx caxsei numd Histological Diagnosis: Grade:Z f Mede2ase lg cli#eDentzLeb Comments: Date  Pathologist  Principal Investigator 5
+
+--- Page 3 ---
+COnSOLIDATeD DIagNOsTIC pAThOLOgy fORm* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION Diffuse STRUCTURAL PATTERN Mosaic  Streaming Necrosis X Storiform Lymphocytic Infiltration Fibrosis Vascular Invasion Y. Palisading Clusterized XCystic Degeneration Alveolar Formation Bleeding Indian File Myxoid Change 2. Cellular features: Psammoma/Calcification Squamous +Adenomatous Squamoid Cell + Sarcomatous Glandular cell + Lympbomatows Spindle Cell Round Cell Cell Stratification Large Cell Y Fibroblast Keratin Small Cell Secretion Osteoblast Desmosome RS CeIVRS Like Intracyt. Vacuole Lipoblast Inflam. Cell Pear!  Gland formation Myoblast Otherwise Specified:  Plasma Cell Dj CO7, brbo% Dz6OZ P45OZa 2.Cellular Differentiation: Well Modsrately Poor Nuclear Atypia: Nuckar Appcarance Aniso Nuclcosis Hyperchromatism Nuclcolar Prominent Multinucleated Giant Cell Mitotic Activity Nuckar Grade Carunna Neta8 to?edto HN M,ssu: Comments:  PATHOLOGIST STAFF FOR RESEARCH USE ONLY). NTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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diff --git a/output/text/c11d1d04-18c1-4fde-ab03-3343f2e9c9f8.txt b/output/text/c11d1d04-18c1-4fde-ab03-3343f2e9c9f8.txt
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index 0000000000000000000000000000000000000000..7e3cd153dc3dfd13e754d60eaa2f831ca0d9b4ec
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+Clinical Diagnosis & History: History of right colon cancer and diverticulitis.  Here for total abdominal colectomy. Specimens Submitted: 1: sp: Terminal ileum and colon; total abdominal colectomy DIAGNOSIS: 1. SP: Terminal ileum and colon; total abdominal colectomy: Tumor Type: Mucinous adenocarcinoma with a minor component that is of conventional (gland-forming) type Histologic Grade:  Moderately to poorly differentiated Tumor Location: Ascending colon Tumor Size: Length is 3.0 cm Width is 2.6 cm Maximal thickness is 0.9 cm Tumor Budding: Extensive Increased Tumor Infiltrating Lymphocytes: Present Precursor Lesions: Tubulovillous adenoma Deepest Tumor Invasion: Subserosal adipose tissue and/or mesenteric fat Gross Tumor Perforation: Not identified Lymphovascular Invasion: Identified Large Venous Invasion: Suspected Perineural Invasion:. Identified Surgical Margins: Free of tumor Polyps/Mucosa Dysplasia (away from the carcinoma): ** Continued on next page **
+
+--- Page 2 ---
+Page 2 of 4 Tubular adenoma; number: 2 Non-Neoplastic Bowel:. Diverticulosis of left colon Appendix: Unremarkable Lymph Nodes: Number with metastasis: 1 Total number examined: 46 Tumor deposits in pericolorectal soft tissue:. Not Identified Tumor Staging (AJcc 7th Edition): pT3 (Tumor invades through the muscularis propria into pericolorectal tissues) Lymph Node Stage (AJcc 7th Edition) :  N1 (Metastasis in 1-3 regional lymph nodes) I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. 1. The specimen is received fresh, labeled "total abdominal colectomy" and consists of a segment of terminal ileum, cecum with attached appendix and colon. The terminal ileum measures 11.0 cm in length and 4.2 cm in circumference at the proximal resected margin.. The remaining colon measures. 96.0 cm in length with a circumference of 6.0 cm at the distal resected margin. The attached appendix measures 8.0 cm in length and averages 0.7 cm in diameter. The appendiceal and intestinal serosa is pink tan and smooth.. Focally hemorrhagic lobulated yellow tan adipose tissue spans the length of the specimen measuring up to 1.3 cm in thickness.. The specimen is opened to reveal a mass lesion measuring 3.0 cm in length and 2.6 cm in width. The mass is located in the ascending colon, 16.1 cm from the proximal margin and 89.0 cm from the distal margin. Sectioning shows that the tumor invades into the muscularis propria. The depth of invasion is 0.9 cm grossly. The are two polyps measuring 0.2 and 0.7 cm in the transverse colon.. Diverticula and muscle wall thickening are present in the distal 14.0 cm of the colon. The remaining mucosa is grossly unremarkable. The attached. adipose tissue is thoroughly examined and all identified lymph nodes are submitted. Representative sections of the specimen are submitted for permanent sections and for Tps.. Summary of sections: p - proximal margin shave ** Continued on next page **
+
+--- Page 3 ---
+Page 3 of 4 D distal margin shave T tumor POL-  two polyps in transverse colon DIV- diverticula A appendix representative sections RS -representative sections. LN lymph nodes. BLN  - bisected lymph nodes. Summary of Sections:. Part 1: Block Sect. Site pCs 1 a 1 bln 1 d 4 div 10 1n 2 5 1 p 1 po1 1 1 rs 1 4 t 4 Addendum Diagnosis. -RESULTS OF IMMUNOHISTOCHEMICAL STAINING FOR DNA MISMATCH REPAIR PROTEINS ARE AS FOLLOWS: MLH1: STAINING PRESENT IN TUMORS MSH2: STAINING ABSENT IN TUMOR MSH6:STAINING ABSENT IN TUMOR PMS2: STAINING PRESENT IN TUMOR CONCLUSION:S -IMMUNOHISTOCHEMICAL STUDIES DEMONSTRATE ABNORMAL MSH2 AND MSH6 PROTEIN EXPRESSION IN THE CARCINOMA. CLINICAL CORRELATION IS SUGGESTED. NOTE: STAINS PERFORMED ON A SEPARATE ADENOMA  SHOW A NORMAL STAINING PATTERN FOR ALL 4 PROTEINS (MLH1, MSH2, MSH6 AND PMS2). Some of the immunohistochemistry and Ish tests were developed and their performance characteristics were determined by the Department of Pathology. They have not been cleared or approved by the US Food and Drug Administration. The FDA has determined that such clearance or approval is ** Continued on next page **
+
+--- Page 4 ---
+Page 4 of 4 not necessary. These tests are used for clinical purposes. . They should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of qualified to perform high complexity clinical laboratory testing. ** End of Report
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diff --git a/output/text/c11d80d0-401c-4b44-bd26-5bdc9ec463a9.txt b/output/text/c11d80d0-401c-4b44-bd26-5bdc9ec463a9.txt
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index 0000000000000000000000000000000000000000..4578eeacd13683a7f1bc2dba1cc0917b1fc842a0
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+
+--- Page 1 ---
+PATIenT HISTOry: Colon cancer. PREOP DIAGNOSIS: Colon cancer. POSTOP DIAGNOSIS: Same. PROCEOURE: Laparoscopic right nemi-colectomy. ADDENDA: Addendum Molecular Anatomic Pathology Testing. Block 2D: A.KRAS codon 12/13 mutation IDENTIFIED (Gly12Val) Note: The quantity and quality of isolated DNA was acceptable for testing. antibody) chemotherapy has recently been reported '. Mutations in the KRAS codon 12/13 gene were found to be associated with resistance to cetuximab therapy, worse prognosis and poor survival in patients with metastatic colorecta! cancer. 1* However, not all tumors reveal such a correlation, therefore the presence of KRAs mutations should be interpreted in the context of the cytologic and histologic findings and the patient's clinicat history.. Addendum Molecular Anatomic Pathology Testing: Block 2D: A. No microsatellite instability detected (Microsatellite stable). Note: The five NC1 recommended dinucteotide and mononucleotide polymorphisms were utilized to assess for microsatellite instability (Msl) by PCR. None of five markers showed evidence of microsatetlite instability.. High-lovel MsI may have prognostic impllcations, and patients with these tumors may be at risk for Mereditary Non.  Polyposis Colorectal Carcinoma syndrome (hnpcC or Lynch Syndrome)(1-6). Genetic testing for germline mutations  associated with that syndrome is indicated in patients with high-levet Msl, after appropriate informed consent and genetic. counseling (1). If clinical suspicion for HNpcc is very high, genetic testing may be appropriate even in cases with microsatellite stable lesions. FINAL DIAGNOSIS: PART 1: LIVER, BIOPSY- METASTATIC ADENOCARCINOMA TO LIVER. Part 2: CoLOn, Right, Right hemIcoLectomy   A.  InvASIVE mOdErATELy DIFFErENTIaTed COLONIc ADeNOcArcinOmA. Tumor measUres 8.0 Cm in gReatest DimensiOn. 3. b. Tumor invaDes Through The muscuLAris PRopria anD exTensiveLy InvoLves  PERICOLONIC ADIPOSE TISSUE AND THE VISCERAL PERITONEAL SURFACE AND INVADeS INTO THE MUSCULARIS PROPRIA OF A PORTION OF SMALL INTESTINE C. ANGIOLYMPHATIC INVASION IS IDENTIFIED. pT4,N2, M1 B. Margins of resection are benign. C.  METASTATIC ADeNOCArCInOMA IS PRESENT IN TEN OF SEVENTEEN LyMpH nODES (1O/17). D. APPENDIX IS PRESENT AND SHOWS SEROSAL INVOLVEMENT BY THE COLONIC ADENOCARCINOMA. E. Separate tusular Adenoma (1.0 cm). CASE SYNOPSIS: SyNOpTIC DATA - PRImARy COLON, RECTAL, APPENDIX TUmORS SPECIMEN TYPE: Right hemicolectomy TUMOR SITE: Cecum TUMOR CONFIGURATION: Infiltrative TUMOR SIZE: Greatest dimension: 6.5 cm INTACTNESS OF MESORECTUM: Not applicable HISTOLOGIC TyPe: Adenocarcinoma HISTOLOGIC GRADE: Low-grade (well to rnoderately differentiated) PATHOLOGIC STAGING (pTNM): pT4b pN2 Number of nodes examined: 17 Number of nodes involved: 10. pM1 Site(s): liver Treatment: Untreated MARGINS: Proximal margin uninvolved by invasive carcinoma Distal margin uninvolved by invasive carcinoma Circumferential (radial) margin - Not applicable  Mesenteric margin uninvolved by invasive carcinoma ANGIOLYMPHATIC INVASION: Present PERINEURAL INVASION: Present TUMOR BORDER CONFIGURATION: Infiltrating ADDITIONAL TUMOR CHARACTERISTICS: None
\ No newline at end of file
diff --git a/output/text/c15572b0-3916-4ca3-be8d-0664c3103af1.txt b/output/text/c15572b0-3916-4ca3-be8d-0664c3103af1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..acfe06836821402f16ccc1263d7d44a1d89569fb
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+TSS ID. TSS ID:t Oc id:. Date of Procurement Gross Description: Labeled left breast lumpectomy. Received is an 85 g unoriented ovoid  portion of lobulated tan fibroadipose tissue measuring 8 x 7 x 3.5 cm. The  specimen contains 2 needle localization wires and there is an accompanying 1cs-0-3 cnrcm0ma unfiHfnattry oluct Nos 85o0f7  specimen mammogram, which is used to orient the specimen and select the Sits: busot prs C509 4/8/n h sections. The radiologist has circled two areas of concern marked 1 and 2, both of which are associated with microcalcifications. The margins are  inked blue for microscopic evaluation. Upon sectioning, area 1 is present  near the midpoint of the long axis and consists of a 2.4 x 1.9 x 1.4 cm  irregular mass. The cut surfaces of the mass are white-tan, smooth and have well-defined borders. The mass grossly abuts the inked margin. At one end of the mass is a 0.7 x 0.3 cm biopsy cavity containing collagen material  and a small metal clip as well as adjacent focal hemorrhage. Area 2 is  present at one end of the specimen and consists of a 1.2 x 0.9 cm ovoid  portion of firm white fibrous tissue that is slightly more dense than the adjacent white fibrous tissue. This area comes to within 0.7 cm of the  nearest inked margin. The remaining cut surfaces are tan and lobulated with  interspersed areas of condensed white fibrous tissue comprising  approximately 25% of the specimen. Poorly-defined areas of blue staining are also present. Microscopic Description: UUID: 5B9C0E4A-3958-4ECF-B8B2-E758E04E7722 TCGA-E9-A1R2-01A-PR Redacted  Microscopic sections of the principal mass (grossly area 1) demonstrate  an infiltrating markedly pleomorphic epithelial neoplasm with a brisk mitotic rate that is arranged in nests. Occasional areas of intratumoral high grade ductal carcinoma in situ are Diagnosis Details: INVASIVE BREAST CARCINOMA CHECKLIST
+
+--- Page 2 ---
+TSS iD 1) Tumor focality: Single focus. 2) Tumor size: 2.4 x 1.9 cm. 3) Histologic type: Ductal 4) Nottingham Combined Histologic Grade: Poorly differentiated. a) Ductule formation: 3 b) Nuclear features: 3 c) Mitotic index: 2 SJ Angiolymphatic invasion: Present 6) Margins: a) Not involved by tumor. b) Distance from closest margin: 1.9 cm (thickness of part B tissue). 7) Lymph nodes: 17 positive/ 19 found.. 8) Size of largest metastatic deposit: 2.1 x 1.2 cm. 9) Extracapsular invasion of !ymph nodes: No. 10) Extensive DCIS component (>25%): No. 11) DCIS component, extratumoral: No. 12) TNM: pT2 pN3a MX. 13)  ERA/PRA: Positive/negative on prior biopsy  14) Her-2/neu over-expression: Negative (score 2) by FISH on prior biopsy Comments: Formatted Path Report: BREAST TISSUE CHECKLIST Specimen type: Lumpectomy Specimen size: Not specified Tumor site: Breast Tumor size: 2.4 x 1.9x 1.4 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinoma
+
+--- Page 3 ---
+TSS ID Histologic grade: Poorly differentiated Tumor extent: Not specified  Lymph nodes: 17/19 positive for metastasis (Axillary 17/19) Extracapsular invasion of the lymph nodes: No Margins: Uninvolved.  Nottingham Histologic Score Tubule formation: Minimal less that 10% (score=3) Nuclear pleomorphism: Marked variation in size, nucleoli, etc (score=3) Mitotic count (25x): 10 to 20 mitoses per 10 HPF (score=2) Mitotic count (40x): Not specified Total Nottingham Score: Grade II (poorly differentiated): 8-9 points Evidence of neo-adjuvant treatment: Not specified. Additional pathologic findings: Not specified Comments: None Laterality: Left, upper outer quadrant
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diff --git a/output/text/c16c06cf-7823-4e22-9df2-fe63e1bac144.txt b/output/text/c16c06cf-7823-4e22-9df2-fe63e1bac144.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6cd48ebf055f200307cc16d9be18e573233f69cb
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+PATHOLOGIC DIAGNOSIS: A SPECIMEN DESIGNATED SIGMOID COLON,PARTIAL COLECTOMY(17 Cm: ADENocARcINOMA,low grade, moderately differentiated (4.9 cm in greatest dimension) Tumor forms a polypoid mass and has an infiltrating border. Tumor invades through muscularis propria. Invasive tumor is 5.0 cm from proximal resection margin,5.1 cm from distal resection margin, and 2.5 cm from radial resection margin. Lymphovascular invasion is not identified. Extramural venous invasion is not identified. Perineural invasion is not identified. Peritumoral lymphoid response (including Crohn?s-like infiltrate) is mild. Residual adenoma is absent. Regional lymph nodes (positive:total):2:13 see also part B. AJCc Classification (6th edition): T3 N1 MX. B. SPECIMEN DESIGNATED "ADDITIONAL PROXIMAL MARGIN: Segment of colon, negative for tumor Two lymph nodes,negative for tumor 0:2). C.SPECIMEN DESIGNATED "DISTAL DONUT Segment of colon, negative for tumor. D. SPECIMEN DESIGNATED PROXIMAL DONUT" Segment of colon, negative for tumor. CLINICAL DATA: History: Not provided. Operation: Sigmoid resection. Operative Findings: Not provided. clinical Diagnosis: Not provided. TISSUE SUBMITTED: A. sigmoid -staple side is proximal to Fs open + return B. additional proximal margin distal donut D.proximal donut GROSS DESCRIPTION: The specimen is received fresh, in four parts, labeled with the patient's name and medical record number. Part A, "#1. Sigmoid, staple side is proximal, open and return",consists of one sigmoid colectomy (17.0 cm in length x 6.6 cm in diameter) with a proximal stapled resection margin (6.6 cm, inked black) and a distal open resection antimesenteric side is inked red where the bowel is opened by the prosector. The mucosal surface demonstrates one tan/pink fungating polypoid mass (4.9 x 4.5 x 1.6 cm) present 5.0 cm from the proximal resection margin5.1 cm from the distal stapled resection margin, and 2.5 cm from the radial resection
+
+--- Page 2 ---
+margin inked orange). The tumor grossly invades into the muscularis, but not the pericolonic fat. There is a white/tan soft nodule (? necrotic lymph node metastasis (1.5 x 0.9 x 1.5 cm which is present in the mesentery adjacent and 2.0 cm from the main mass and 1.1 cm from the radial margin. The remainder of the mucosa is tan/brown and unremarkable. Twelve candidate lymph nodes are identified, the largest measuring 0.7 cm in greatest dimension. Gross photographs are taken. Micro Al: Proximal and distal stapled resection margins,2 frags, Micro A2:Tumor,2 frags, Micro A3 through A4: Tumor with deepest extent of invasion, 1 frag each Micro A5 through A6: Tumor to normal mucosa,1 frag each, Micro A7 through A8:Mesenteric nodule 1 frag each, Micro A9: Radial margin,1 frag, Micro Al0: Normal mucosa,1 frag, Micro A20 through A22: Representative sections of fat, Part B,"#2.Additional proximal margin"consists of one unoriented segment of colon (1.1 cm in length x 2.5 cm in diameter) with two stapled resection margins (4.5 cm inked black,4.1 cm inked blue) with attached mesentery (2.1 x 6.0 cm). No lesions are grossly identified.Two candidate lymph nodes are identified, the largest measuring 0.5 cm in greatest dimension. Micro B1 through B2: Proximal margin,full gth sections,2 frags each, Micro B3: Candidate lymph nodes,3 frags, Micro B4 through B5: Additional adipose tissue, multi frags each, Part C," #3.Distal donut"consists of one segment of colon 0.8 cm in length x 2.5 cm in diameter). No lesions are grossly identified. Micro C1 through C2: Distal donut2 to 3 frags each Part D#4Proximal donutconsists of one metal disc 2.8x 2.8 x0.5 cm with an attached stem(4.4 cm in length x 0.7 cm in diameter) with a segment of colon (0.5 cm in length x 1.2 cm in diameter.No lesions are grossly identified. The metal object is submitted for gross examination only. Micro Dl: Proximal donut, 1 frag, By his/her signature below, the senior physician certifies that he/she personally conducted a microscopic examination ("gross only" exam if so stated) of the described specimen(s) and rendered or confirmed the diagnosis(es) related thereto.
\ No newline at end of file
diff --git a/output/text/c18c4d87-f439-4f0e-9d8b-8bd83f25104f.txt b/output/text/c18c4d87-f439-4f0e-9d8b-8bd83f25104f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..51833a6aaf52c10d681d6ac75f0188c8ead035a6
--- /dev/null
+++ b/output/text/c18c4d87-f439-4f0e-9d8b-8bd83f25104f.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+Page 1 of 4 UUID:82B46073-10CE-4D05-9421-6308E3FAD1AD TCGA-VZ-AZHO-01A-PR Final Pathologic Diagnosis. CORRECTED REPORT: A) SENTINEL NODE #1 (EXCISION): One lymph node involved by metastatic carcinoma (1/1). B) SENTiNEL NODE #2 (EXCISION): One out of two lymph nodes, involved by metastatic carcinoma (micrometastases) (1/2). C) SENTINEL LYMPH NODE #3 (EXCISION): One out of two lymph nodes, involved by metastatic carcinoma (micrometastases) (1/2). D) Right Breast (mAstecTOmy): Invasive ductal carcinoma, Nottingham grade 2. See synoptic report. E) NEW INFERIOR MARGIN (EXCISION): Breast tissue with benign fibrocystic changes, including ductal hyperplasia and apocrine metaplasia. Negative for malignancy.. NOTE: This corrected report is being issued due to a typographical error In the original report. The initial diagnosis rendered by remains unchanged. I attest I have personally reviewed the specimen/slides and agree with the above findings. zcDO-3 enond, igilhatiry duct NOS 850013 Site (R BrsrotNoS C 5D 9 rath Synoptic Report R Buest, Jour oute gudian! D: BREAST, MASTECTOMY - SPECIMEN TYPE: C so5 Mastectomy QI qJ25/13 LYMPH NODE SAMPLING:E  Sentinel lymph node with axillary dissection SPECIMEN SIZE:
+
+--- Page 2 ---
+Page 2 of 4 Greatest dimension: 30 cm *Additional dimensions:7.0 x 2.5 LATERALITY: Right TUMOR SITE: Lower outer quadrant. SIZE OF INVASIVE COMPONENT: Greatest dimension: 2.0 cm *Additional dimensions:1.5 x 1.0 cm Two separate lesions were present, each one measuring 2.0 x 1.5 x 1.0 cm.. HISTOLOGIC TYPE: Ductal carcinoma in situ Invasive ductal carcinoma HISTOLOGIC GRADE: Tubule formation: Moderate 10% to 75% (score = 2) Nuclear pleomorphism: Marked variation in size, nucleoli, chromatin clumping, etc. (score =. 3) 0 to 5 mitoses per 10 HPF (score = 1)  Nottingham Grade II: 6-7 points PRIMARY TUMOR (pT): pT1c: Tumor more than 1.0 cm but not more than 2.0 cm in greatest dimension. REGIONAL LYMPH NODES (pN): pN2a: Metastasis in 4 to 9 axillary lymph nodes (at least 1 tumor deposit greater than 2.0. mm) Number examined:18 Number involved: 5 DISTANT METASTASIS (M): pMX: Cannot be assessed MARGINS:  Margin(s) involved by invasive carcinoma Specify which margin(s): Inferior margin at mastectomy (specimen D). See comment.. *EXTENT OF MARGIN INVOLVEMENT FOR INVASIVE CARCINOMA *VENOUS/LYMPHATIC (LARGE/SMALL VESSEL) INVASION (V/L): *Present *MICROCALCIFICATIONS: *Present in DCIS *ADDITIONAL PATHOLOGIC FINDINGS: Fibrocystic changes, biopsy site related changes, and columnar cell hyperplasia. *COMMENT(S): The inferior margin is invovled by carcinoma in the mastectomy specimen (specimen D).. however, additionally submitted inferior resection margin is not involved (specimen E). Clinical. correlation is necessary for interpretation of these findings. Diagnostic Comment According to previous biopsy, 65% of tumor cells show moderate to strong nuclear staining for estrogen receptors, 80% of tumor cells show nuc!ear staining show strong nuclear staining for progesterone receptors, and Her2-neu gene is not amplified by FiSH (please see report
+
+--- Page 3 ---
+Page 3 of 4 SurgicalFinal.Re poraryCopy Intraonerative Diagnosis TP A1: Touch prep positive for carcinoma. No frozen done. TP B1: No touch preps done because first sentinel lymph node is positive. TP C1: No touch preps done because first sentinel iymph node is positive. Clinical History  year old female with breast cancer.. Pre/Post-operative Diagnosis Breast cancer.e Gross Anatomic Description. (SPECIMEN D: Dictated by) (SPECIMENS A-C and E: Dictated by Specimens received in five containers. Snecimen A: Designated "sentinel node #1" is received fresh for intraoperative consultation on fabeled with the patient's name and "sentinel node #1". Specimen consists one piece of yellow tissue measuring 1.2 x 1.0 x 0.6 cm. The lymph node is bisected. Touch prep is done. No frozen section is performed. Section code: A1 -- two pieces, one lymph node, entire specimen. Specimen B; Designated "sentinel node #2" is received fresh for intraoperative consultation on iabeled with the patient's name and "sentinel node #2". Specimen consists of one yellow/tan irregular fragment of tissue measuring 0.8 x 0.6 x 0.3 cm. No intraoperative procedure performed. Entirely submitted for permanent sections.. Section code: B1 -- entire specimen.. Specimen C: Designated *sentinel node #3" is received fresh for intraoperative consuitation on labeled with the patient's name and "sentinel node #3". Specimen consists of one yellow/tan fatty fragment of tissue measuring 0.8 x 0.4 x 0.4 cm. The specimen is bisected revealing one lymph node. No intraoperative procedure performed. Entirely submitted for permanent sections. Section code: C1 -- two pieces, one lymph node, entire specimen. Specimen D: Designated "right mastectomv (stitch on lateral margin, clip on apex of dissection)" is received fresh for Tumor Bank on. iabeled with the patient's name, MRN and "right. mastectomy (stitch on lateral margin, clip on apex of dissection)". Specimen consists of one right radical mastectomy with attached axillary tail weighing 220.8 g. The specimen measures 30.0 x 7.0 x 2.5 cm. The axillary tail measures 13.0 x 3.5 x 2.0 cm. The breast measures 17.0 x 6.0 x 2.5 cm. There is an overiying ellipse of tan wrinkled skin measuring 15.0 x 6.0 cm. There is an unremarkable nipple measuring 1.5 cm in diameter and 0.5 cm in thickness. The areola measures 4.0 x 3.5 cm and is unremarkable. The external palpation of skin reveals two firm masses which are inferior lateral to the nipple, at the outer lower quadrant. One is at 3.5 cm from the nipple and the other is at 2.0 cm from the nipple. The suture is identified which denotes the lateral margin. Cut surface reveals two white/tan spiculated tumors. The medial tumor measures 2.0 x 1.5 x 1.0 cm with what appears to be a. previous biopsy site. The more lateral tumor mass measures 2.0 x 1.5 x 1.0 cm and also appears to have a previous biopsy site. The tumor masses appear to be connected by a white/tan tract of tumor
+
+--- Page 4 ---
+Page 4 of 4 measuring 0.5 x 0.2 x 0.2 cm. The lateral tumor comes within <0.1 cm of the inferior margin and 0.2 cm of the deep margin. The medial tumor comes within 0.1 cm of the inferior margin and appears to abut the deep margin. Both tumors are >3.0 cm from the superior and medial margins. The remainder of the cut sections are grossly unremarkable as yellow/tan fatty fibrous tissue. There is a free floating fragment of breast tissue measuring 8.5 x 1.5 x 0.5 cm with a staple denoting the media! position. The fragment weighs 3.9 g. This fragment is oriented with the assistance of according to him, it represents the deep margin. The fragment is oriented regarding lateral and medial and aspects. The axillary tall is dissected and eleven lymph nodes are identified. The lateral tumor comes within ~0.2 cm of skin and the medial tumor comes within 1.0 cm of skin.. Inking code - breast: Green -- superior portion of breast; Blue -- inferior portion of breast; Black -- deep. portion of breast: Orange -- area of further resection, inferiorly, adjacent to additional inferior margin (specimen E). Inking code -- additional fragment of tissue (deep margin): Black -- entire external surface of free deep fragment; Green -- medial tip of free deep fragment.. Section code: D1 -- representative section of tumor closest to nipple; D2 -- representative section of tumor farthest from nipple; D3 - tip of nipple, serially sectioned; D4 -- remainder of nipple, en face; D5 -- section of medial tumor with skin and orange margin; D6 -- representative section of medial tumor with skin and orange margin; D7 - representative portion of tissue between described tumors to contain described tumor tract; D8 -- representative section of lateral tumor with skin; D9-D10 -- representative sections of lateral tumor with skin (sections through tumor were made from medial to Iateral); D11-D12 -- two representative sections of unremarkable breast tissue from medial inferior quadrant; D13-D14 -- representative sections of unremarkable breast tissue from superior medial quadrant; D15-D16 - representative portions of unremarkable breast tissue from superior lateral quadrant; D17-D18 -- representative sections of unremarkable breast tissue and lateral inferior quadrant; D19 -- one lymph node, bisected; D20 -- one lymph node, bisected; D21 -- two lymph nodes submitted wholly with the more proximal node inked in black; D22 - two lymph nodes submitted wholly. with the more proximal lymph node inked in black: D23 -- one tymph node, bisected; D24 -- two lymph nodes submitted wholly with the more proximal lymph node inked in black; D25 -- two lymph nodes with the more proximal node inked in black (the lymph nodes were submitted from proximal to distal):  D26 -- inferior margin; D27 - lateral margin; D28 -- medial margin; D29 -- superior margin; D30 -- deep posterior margin; D31-D36 -- deep free fragments of breast tissue serially sectioned from medial to Iateral. Specimen E: Designated "new inferior margin" is received in formalin iabeled with the patient's name and "new inferior margin". Specimen consists of one yellow/tan fatty fragment of tissue weighing 10.6 g and measuring 5.5 x 2.5 x 1.0 cm. The new inferior margin is inked in blue and the specimen is serially sectioned. Cut sections reveal a yellow/tan fatty interior that is grossly unremarkable. Section code: E1-E6 - entire specimen. hw s|3i3
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diff --git a/output/text/c19fcbee-9f71-4c88-b457-6b6c85cdb4ee.txt b/output/text/c19fcbee-9f71-4c88-b457-6b6c85cdb4ee.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e379bbd5a36713666cb7fcfa1c8d9ce1168d45e9
--- /dev/null
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+
+--- Page 1 ---
+IC - 0 - 3 Carcioma, mfiltrstig oluctl, nts 85os/3 Sih: Brsot Nts C50.9 119fujw Diagnosis: 1. Ablated breast sample with a moderately differentiated invasive ductal carcinoma (tumor diameter: 2.7 cm). Tumor-free dorsal resection margin. Concluding tumor classification: NOS, G II, pT2N0L0V0R0
\ No newline at end of file
diff --git a/output/text/c1a12bca-94c8-4795-8145-fdea73497810.txt b/output/text/c1a12bca-94c8-4795-8145-fdea73497810.txt
new file mode 100644
index 0000000000000000000000000000000000000000..89a5b5541640577a123b004b8abf9cdb73f570b0
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+FINAL DIAGNOSIS: PArt 1: pancReAS, uncinatE, biOpSy -- ADENOCARCINOMA (see comment). Part 2: gallbladder, Cholecystectomy -- CHRONIC CHOLECYSTITIS. PART 3: GASTRODUODENAL LymPH NODE, EXCISION -- ONE (1) BENIGN LYMPH NODE. PART 4: PANCREAS, HEAD, BIOPSy - . ADENOCARCINOMA (see comment). PARt 5: STOmaCh, DUODeNUm, PANCREaS, bILE DUCT, WhIpPLE RESECTIOn - A. INVASIVE WELL DIFFERENTIATED ADENOCARCINOMA OF THE HEAD OF THE PANCREAS (3.8 CM). B. THE CARCINOMA INVADES BEYOND THE PANCREAS TO INVOLVE THE PERIPANCREATIC SOFT TISSUE AND DUODENUM. C. METASTATIC ADENOCARCINOMA IS PRESENT IN ONE OF THIRTEEN (1/13) PERIPANCREATIC LYMPH NODES. D. PROXIMAL GASTRIC, DISTAL DUODENAL, BILE DUCT, PANCREATIC, RETROPERITONEAL AND VASCULAR GROOVE MARGINS ARE NEGATIVE FOR TUMOR. E. PAnCREATiC InTRAEPITHELiAL NEOPLASIA, GRADE 3 (PAnIN-3). F. PATHOLOgiC STAgE; pT3, N1, m1 (SEE,PART 6). PART 6: TRANSVERSE MeSOCOLON, EXCISION -- A. METASTATIC ADENOCARCINOMA INVOLVING FIBROADIPOSE TISSUE B.  One (1) benign lymph node. PART 7: TRANSVERSE MESOCOLON, LYMPH NODE, EXCISION - One (1) benign lymph node. COMMENT: The biopsies of the pancreas are diagnostic of adenocarcinoma in comparison to the main resection specimen which shows a well-differentiated adenocarcinoma with features similar to those seen in the biopsies. SYNOPTIC DATA - PRIMARY PANCREAS(EXOCRINE) TUMORS -- MACROSCOPIC - SPECIMEN TYPE:  Pancreaticoduodenectomy (Whipple resection), partial pancreatectomy TUMOR SITE: Pancreatic head TUMOR SIZE: Greatest dimension: 3.8 cm Additional dimensions: 3.2 x 2.5 cm OTHER ORGANS RESECTED: Gallbladder - - MICROSCOPIC - HISTOLOGIC TYPE:  Ductal adenocarcinoma HISTOLOGIC GRADE: G1 PATHOLOGIC STAGING (pTNM): pT3 pN1a Number of lymph nodes examined: 13 Number of lymph nodes involved: 1 pM1 Site(s): transverse mesocolon (part 6) MARGINS: Common bile duct margin uninvolved Pancreatic parenchymal margin uninvolved Uncinate process/retroperitoneal margin uninvolved. SMV/portal vein notch margin uninvolved. Proximal duodenal/gastric margin uninvolved. Distal duodenal margin uninvolved Distance of invasive carcinoma from closest margin: 2 mm Margin: vascular groove VENOUS/LYMPHATIC (LARGE/SMALL. VESSEL) INVASION (V/L): Present PERINEURAL INVASION: Present ADDITIONAL PATHOLOGIC FINDINGS: Pancreatic intraepithelial neoplasia (highest grade: PanIN 3)
\ No newline at end of file
diff --git a/output/text/c1acaccb-b212-4789-92cd-79c0d743f1a4.txt b/output/text/c1acaccb-b212-4789-92cd-79c0d743f1a4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..04711647b0d3e09dc31fc03f11e6dcf1b5b35f34
--- /dev/null
+++ b/output/text/c1acaccb-b212-4789-92cd-79c0d743f1a4.txt
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+
+--- Page 1 ---
+Referring Physician:. Patient:  UUID: 5CF85AF1-D227-430C-99CD-C2A524CFFA29 Redacted TCGA-AC-A2QI-01A-PR DOB: Ref#: Patient Location:. Date Received: Outpatient Cas Date of Service:. Room: Bed: Date Reported: A copy of this report will be faxed to: FInAL SuRgICaAL PAthOLOgy REPORt Diagnosis: A. -C) RIght breASt wIth AXilLAry SenTineL Lymph nODes, MAsteCTomy WITH SENTINEL LYMPH NODE BIOPSIES (X 2). - Invasive lobular carcinoma (multicentric), Nottingham grade 2. - Main tumor mass measures 57 mm in diameter. - Lobular carcinoma in situ (LCiS), comprising less than 5% of tumor volume. - Resection margins are free of tumor. - Invasive tumor is focally present 2 mm from the deep (pectoralis fascia) margin, and is at least 30 mm from all other margins. - Metastatic carcinoma is present in two sentinel lymph nodes (2/2). - Metastatic carcinoma is diffusely present throughout both lymph nodes. - No extranodal extension is present. 1cs-0-3 carcmoma nifiHtnafirg 1o beIav,nD5 85a0/3 PATHOLOGIC TUMOR STAGING SYNOPSIS: Sit: brsot,N0s C5O.9 Type and grade (invasive): Invasive lobular carcinoma, grade 2. Jw 9/3/1 Type and grade (in situ): Lobular carcinoma in situ, nuclear grade 2. Primary tumor: pT3. Regional lymph nodes: pN1a. Distant metastasis: pMX. Pathologic stage: IIIA. Lymphovascular invasion: Present. Margin status: Negative (R0). COMmENT: The main tumor mass measures 57 mm in diameter. The tumor cells diffusely infiltrate a relatively discrete dense fibrous area in the central breast. A few smaller foci of invasive lobular carcinoma and LCIS are present in representative sections taken away from the main tumor mass, but the main tumor burden is in the central breast. The pathology findings were telephoned to Dr.  Pathology Consultation Report Page 1 Case #: This report continues... (FiNAL). Printed: Phoni
+
+--- Page 2 ---
+Patient: Case #: FiNAL SURGICAL PATHOLOGY REPORT Page 2 Patholoav Coneultatian Case #: This report continues... (FiNAL) Printed: Phone:
+
+--- Page 3 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT Breast Invasive Tumor Staging Information (AJCC Cancer Staging Handbook, 7th Ed, and CAP protocol, Oct 2009). This staging also incorporates: Previous biopsy: Breast profile: Specimen type: Total breast. Mastectomy with sentinel lymph node biopsies x Specimen procedure: 2. Sentinel lymph nodes. Lymph node sampling: Single intact specimen. Specimen integrity: Right. Specimen laterality: 17 x 12.5 x 2.5 cm. Specimen size (other than mastectomy): INVASIVE TUMOR FEATURES: Invasive tumor size: 57 mm. Central. Invasive tumor site: Invasive tumor focality: Multicentric (central, UOQ, LIQ, LOQ) Invasive lobular carcinoma.. Histologic type: Total Nottingham Grade: 2 of 3 (intermediate grade).. Tubule formation: 3 0f 3. Nuclear Pleomorphism: 2 of 3. Mitotic count for Nottingham:. 1 0f 3. Mitotic count: Five mitoses in ten high power fields. Lymphatic invasion: Present. MARGIN STATUS FOR INVASIVE COMPONENT: 2 mm. Distance of tumor from margins: Closest margin: Deep (bounded by pectoralis fascia).. Invasive carcinoma is at least 30 mm from all Other margins: other margins. LOBULAR CARCINOMA (LCIS) FEATURES: Extent: LCIS present in association with invasive carcinoma, and in representative sections away from main tumor mass. Nuclear grade: Intermediate grade. Necrosis: Not present. Calcifications: Not present.
+
+--- Page 4 ---
+FINAL SURGICAL PATHOLOGY REPORT Negative. Margin status for LCIS component At least 10 mm. Distance of In-situ from nearest margin:. Unremarkable. Skin: Unremarkable. Nipple: No skeletal muscle present. Skeletal Muscle: INVASIVE PATHOLOGIC TUMOR STAGING (pTNM) pT3. Primary tumor (pT): pN1a. Regional lymph nodes (pN): pMX. Distant metastasis (pM): RECEPTOR STATUS AND HER2/NEU: POSiTIVE (100% positive ceils, strong intensity) Estrogen receptors: Negative (less than 1% positive cells).. Progesterone receptors: Not overexpressed (iHC score 1+). Her2/neu: 12% positive cells. Ki-67 proliferative index: Signed by : Source of Specimen: A. Right Axillary Sentinel Lymph Node. B. Right Breast total mastectomy. C. Sentinel lymph node;Right Axillary Sentinel Lymph Node Gross Description: A. The specimen is labeled right axillary sentinel lymph node #960 and is received in formalin. It consists of a 2.9 x 2.2 x 0.7 cm discoid lobulated portion of fatty tissue. On dissection a single 1.6 x 0.7 x 0.5 cm. Iymph node is recovered. The node is serially sectioned and entirely submitted in cassette A1. B. The specimen is labeled right breast and is received without fixative. It consists of a mastectomy specimen which weighs 232 grams. A suture marks the tail of the breast. With this orientation, the specimen measures 12.5 cm from superior to inferior, 17 cm from medial to lateral and 2.5 cm from. superficial to deep. There is an overlying 15.5 x 7 cm ellipse of mottled tan to pale red skin. Mediaily and inferiorly within the skin is a 2.8 cm areola and a slightly retracted appearing 0.8 cm nipple. The skin is. bulging but otherwise unremarkable. The anterior-superior margin is inked blue, the anterior-inferior. margin is inked green, and the posterior margin, which consists of smooth fascial tissue is inked black. The breast is serially sectioned at close intervals to reveal a central firm and relatively well circumscribed area of fibrous breast parenchyma. This fibrous parenchyma overall measures 5.7 cm from medial to lateral, 2.5 cm from superior to inferior, and 1.7 cm from superficial to deep. The fibrous tissue is separated from the deep margin by a thin layer of movable fascial tissue. The fibrous breast parenchyma is 3 cm from the. Page 4 Pathology Consultation Report Case #: This report continues... (FINAL) Printed: Phone:
+
+--- Page 5 ---
+Datiant. Case #: FINAL SURGICAL PATHOLOGY REPORT inferior margin, 3 cm from the superior margin, 4 cm from the medial margin, and 6 cm from the lateral margin. It is 1 cm from the closest skin and abuts the fascial margin of the posterior breast centrally.. Representative samples of this tissue are obtained for research purposes. Sections of this fibrous breast. tissue reveal a central and inferiorly located area of hemorrhage with a twisted biopsy site clip. The remainder of the breast is composed predominantly of fatty tissue but rubbery fibrous parenchyma extends to the lower-outer quadrant. There are no obvious lymph nodes in the tail of the breast. Representative sections are submitted. Section summary: B1) nipple and tissue just deep to nipple, B2) central deep margin (fascial tissue), 83) medial edge of central fibrous tissue, B4) superior edge of central mass,. B5) inferior portion of central mass (biopsy site clip here),. B6-B7) additional central sections of tumor (B6 has deep margin),. B8) lateral edge of fibrous mass,. B9) representative sections upper-inner quadrant, B10) representative sections lower-inner quadrant, B11) representative sections upper-outer quadrant B12) representative sections lower-outer quadrant. and is received in formalin. C. The specimen is labeled right axillary level two sentinel lymph node. It consists of a 0.9 x 0.6 x 0.5 cm tan lymph node with a small amount of adherent adipose tissue. The specimen is serially sectioned and entirely submitted in cassette C1.. Microscopic Description: A. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered. B. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered. C. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis. rendered. Pathology Consultation Report Page 5 Case #: REPRINT: Orig. printing on Printed: Phone
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diff --git a/output/text/c1c7641a-f846-41ca-a6b7-f0a793452cbf.txt b/output/text/c1c7641a-f846-41ca-a6b7-f0a793452cbf.txt
new file mode 100644
index 0000000000000000000000000000000000000000..bc37a8d5b0f718e96d587e165311412b90f20d86
--- /dev/null
+++ b/output/text/c1c7641a-f846-41ca-a6b7-f0a793452cbf.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+/cs-0-3 Carciomn, nfiltrntrny ductal,nos 850sf3 8it: brst,nos C50.9 1/08/1 ID#: Pathology Form Specimen Information Collected by. Date: 2Time: Preserved by: Date: *-  Time: SPECIMENTYPE (#of samples.provided)  Frozen Paraffin Block  Blood/Serum/Plasma Slide Diseased  Normal Diseased Normal Diseased Normal Diseased Normal 2 4 2 2 Time to LN2 Time to Formalin Time to LN2 /2 min /3 min min NPATHOLOGICAEDESCRIPTIONH Primary Tumor Organ Size Extension of Tumor. Distance to NAT BReasT Jumer 4 x3 x2j~cm 5 cm Lymph Nodes Location # Examined # Metastasized Distant Metastasis. Organ Detailed Location Size Pathological Staging pTX NA m o Stage: I Notes: pReasTnodey 2 C Ms, M2) in Nj`fRcgeo (2ujaS Ms ( jilive pUsi Zi ve UUID: 140F8918-739F-498A-9A17-B307E40E6060 M 2 Redacted TCGA-C8-A137-01A-PR
+
+--- Page 2 ---
+ID#: Microscopic Description Cell Distribution + Structural Pattern  Diffuse  Streaming  Mosaic Storiform  Necrosis Fibrosis Lymphocytic Infiltration Palisading Vascular Invasion Cystic Degeneration Clusterized  Bleeding Alveolar Formation Myxoid Change Indian File  Psammoma/Calcification Cellular Differentiation Squamous Adenomatous + Sarcomatous + Lymphomatous  Squamoid Cell Glandular cell x  Round Cell  Large Cell Spindle Cell Cell Stratification Fibroblast Small Cell  Keratin Secretion Osteoblast RS Cell/RS Like  Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell  Gland formation  Myoblast Plasma Cell  Pearl Cellular Differentiation: Well Moderate ()  Poor w a* a Nuclear Appearance. Nuclear Atypia: 0 1 I1 III  Aniso Nucleosis Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell Y Mitotic Activity Nuclear Grade: Value Date Marker Result ER  Negative   Positive PR  Negative.  Positive Her-2/neu  Negative  Positive B-Cell Marker  Negative   Positive T-Cell Marker  Negative  Positive Other:  Negative  Positive Other:  Negative  Positive Final Pathology Report FnB(tra Ting ductre carcinoma Histological Diagnosis: Grade:I BreasT nsdeg 7 (posjtiveg 3, NegitiVe 4 Comments: Date Pathologist sepa 5
+
+--- Page 3 ---
+COnsOlIDateD DIagnostIc paThOLOgy fOrm* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION Diffuse + STRUCTURAL PATTERN Streaming + Mosaic Necrosis Storiform QFibrosis Lymphocytic Infiltration X K Palisading Vascular Invasion Cystic Degeneration Clusterized XBleeding Alveolar Formation Myxoid Change  Indian File x Psammoma/Calcification 2. Cellular features: Squamous Adenomatous +  Sarcomatous Lym phomatous Squamoid Cell Glandular cell Round Cell Spindle Cell Large Cell Cell Stratification Fibroblast Small Cell Keratin  Secretion Osteoblast  RS CeI/RS Like Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell Pearl Gland formation  Myoblast Plasma Cell Otherwise Specified: D1 807c Dz Zo7 Dr7O7 Dy3U 2.Cellular Differentiation: Well Moderately Poor 3.Nuclear Atypia: Nackar Appearance Aniso Nucleosis Hyperchromatism 4  Nucleolar Prominent Multinucleated Giant Cell 47 Mitotic Activity Nuckar Grade Histological Diagnosis: sltps/ay buetal Cateinssxe Uk C-3 C0einsxro metustG8s3sd to CN Comments:L M. Date  PATHOLOGIST STAFF FOR RESEARCH USE ONLY).E INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND .
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diff --git a/output/text/c1e924bf-bf54-4e5f-9879-fc7bc3fcb767.txt b/output/text/c1e924bf-bf54-4e5f-9879-fc7bc3fcb767.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7df0fa72b125e91b8714736faad77c1e0d55cf29
--- /dev/null
+++ b/output/text/c1e924bf-bf54-4e5f-9879-fc7bc3fcb767.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+A description for each data field can be found in the 'Data description' worksheet (yellow tab). Sample Collection Details Sample Number  Sample Sample Site of Site of Year of  Age at Type Preparatio Tissue  Primary Sample  Sample n (Event) Collection  Collection (yrs) BUFFY FF RENL TUMOUR FF Left Kidney RENL
+
+--- Page 2 ---
+Histology and staging Sample Days to Days to Type of Site of Primary Tumour  Histology Grade/ Comments Procedure Diagnosis Size (cm) Differentiat Date ion RESECT L. Kidney 4 Papillary renal car. Type II x RESECT  L. Kidney 4 Papillary renal car. Type II +
+
+--- Page 3 ---
+Pathologic Pathologic Clinical M Histology  Slide URL al T aI N Comments T1,NOS NX MX T1,NOS NX MX
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diff --git a/output/text/c1ff24a2-a2ba-4ed3-8e4a-54d81dace6f3.txt b/output/text/c1ff24a2-a2ba-4ed3-8e4a-54d81dace6f3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..02c99063c5be6205aae105e2e34eb135513512a1
--- /dev/null
+++ b/output/text/c1ff24a2-a2ba-4ed3-8e4a-54d81dace6f3.txt
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+
+--- Page 1 ---
+TeD O-3 Sobeleer arcinoma. ingestratrg 85q03 LNOS CGC CsD.9 pat BueI,ipper sutir. guaclioe Final Surgical Pathology Report C504 Procedure: 4|1213 Diagnosis A. Lymph nodes, left axillary sentinel, excision - Metastatic carcinoma in two of two (2/2) lymph nodes in this part. B. Breast, right, excision - Invasive lobular carcinoma, 0.5 cm in greatest dimension (see microscopic description, including for prognostic marker results). Lobular carcinoma-in-situ. Fibrocystic changes, with microcalcifications present. Skin, nipple, and deep margin negative for tumor. C. Breast, left, excision - Invasive lobular carcinoma, forming a 3.2 cm in greatest dimension mass, with additional scattered foci of invasive lobular carcinoma present. Invasive lobular carcinoma present at least very near (<l mm from), and. possibly at, the deep margin in the separate foci. Skin and nipple negative for malignancy. Lobular carcinoma-in-situ. Biopsy site changes. Fibrocystic changes, with microcalcifications present. D.  Lymph nodes, left axillary, excision - Metastatic carcinoma in nineteen of twenty-two (19/22) lymph nodes in this part, including with metastatic carcinoma in the superior-most lymph node. Microscopic Description: A,D. There is metastatic carcinoma in two of two (2/2) sentinel lymph nodes in part A, and in nineteen of twenty-two (19/22) lymph nodes in part D. Thus overall in this case, there is metastatic carcinoma in. twenty-one of twenty-four (21/24) lymph nodes (pN3a). There is extracapsular extension. The largest involved lymph node is one of the. sentinel lymph nodes, 2.5 cm in greatest dimension. The largest lymph node in part D is negative for tumor.  There is metastatic carcinoma in. the superior-most lymph node in part D..  Please note that in addition to examining H&E stained sections, immunostains with antibodies to keratin (AEi-AE3) were examined on representative blocks in both parts to aid in assessment. B. The following template summarizes the findings in this part: Invasive carcinoma: Present Histologic type: Invasive lobular carcinoma, identified incidentally in block B4 Histologic grade: UUID:A8834D03-81F5-43BC-A4AB-F215C89CB095 Overall grade: 2 TCGA-A7-A5Zx-01A-pr Redacted Architectural score: 3 Nuclear score: 2 Mitotic score: 1 Greatest dimension (pT): slightly >0.5 cm (pTlb) Specimen margins: Negative Vessel invasion: Not identified Nipple: Negative for tumor Invasion of skin or chest wall: Not identified
+
+--- Page 2 ---
+Ductal carcinoma in situ: Not identified Description of non-tumorous'breast: Fibrocystic changes, with microcalcifications present. Please note Comments: There is also lobular carcinoma-in-situ present. that immunostains with antibodies to p63, keratin (AE1-AE3), and e-cadherin were examined on representative blocks to aid in assessment. Distant metastasis (pM): Not applicable Breast prognostic marker results. Results Estrogen receptor: 80% / moderate intensity Progesterone receptor: 5% / weak intensity Her2 by IHC: 1+ Interpretation Estrogen receptor: Positive. Progesterone receptor: Weakly positive Her2 by IHc: Negative for Her2 expression Comments Fixation time: 30:00 Cold ischemia time: 0:30 The analyzed tissue met quality requirements of the Asco/cAp guidelines for Her2 testing.  Control materials stained appropriately.. Based on data collected in our laboratory and reported in the literature we recommend FIsh analysis for Her2 in cases that stain with intermediate intensity by immunohistochemistry.. Prognostic markers were done by immunohistochemical stain on paraffin sections from 10% neutral buffered formalin fixed tissue using antibodies on a Benchmark automated stainer. The Her2 antibody is clone 4B5 and has'been approved by the FDA as an aid in the assessment of breast cancer patients for whom Herceptin treatment is considered. This laboratory meets the test validation and quality assurance requirements of the Asco/cAP guidelines for Her2. ER and PR testing for. carcinoma of the breast C. The following template summarizes the findings in this part: Invasive carcinoma: Present. Histologic type: Invasive lobular carcinoma. Invasive lobular carcinoma is identified comprising the main mass lesion, as well as in multiple additional foci in random sections of this breast (blocks c7, C8,  C10, cll). Histologic grade: Overali grade: 2 Architectural score: 3 Nuclear score: 2 Mitotic score:  Greatest dimension (pT): The main mass lesion is 3.2 cm in Specimen margins: Although the margins surrounding the main mass lesion are negative, tumor in the additional foci of invasive lobular carcinoma is present at least very near (<l mm from), and possibly at, the deep margin, with fragmentation hindering assessment. Vessel invasion: Not identified Nipple: Negative for tumor. Invasion of skin or chest wall: Not identified.
+
+--- Page 3 ---
+Ductal carcinoma in situ: Not identified Description of non-tumorous breast: Fibrocystic changes, with microcalcifications present. Biopsy site changes.. Comments: There is also lobular carcinoma-in-situ present. Please note that immunostains with antibodies to keratin (AEl-AE3), and e-cadherin were examined on representative blocks to aid in assessment. Distant metastasis (pM): Not applicable. Prognostic markers: Previously performed Note: have reviewed this case. [A few of the antibodies used in our laboratory may be classified as analyte specific reagents. These antibodies are monitored and controlled in our laboratory and their performance for in vitro diagnosis is well described in the medical literature.  They have not been cleared or approved by the FDA.] Specimen A.  Left axillary sentinel node. B. Right breast C. Left breast D. Left axillary contents Clinical Information CLINICAL HISTORY: yo white female with invasive lobular cancer left breast Intraoperative Consultation A. Metastatic carcinoma present. Gross Description A.  Received fresh in a container labeled "left axillary sentinel node" is a portion of tissue which is tan-yellow and fatty externally. On palpation, it appears to consist of two adherent lymph nodes, spanning an area 2.5 x 1 x 0.5 cm and 1.8 x 1 x 0.4 cm.  On cut surface, both vary from soft and tan to yellow, to firmer and tan-white. The specimen is entirely submitted for frozen section in two blocks, with one lymph node per block.. B. Received fresh (excised at received at placed in formalin at , in a container labeled "right breast" is a 21 cm from superior to inferior x 18 cm from medial to lateral x 3.2 cm from anterior to posterior soft tan-yellow mastectomy specimen, with an orienting suture present. On the anterior surface there is a 7.6 x 4.4 cm tan-white skin ellipse, with a centrally located 1.3 x 1.3 x 1 cm nipple. The intact deep margin is inked, and the specimen is serially sectioned. On cut surface, the specimen consists of interspersed yellow adipose tissue and tan tissue, without focal lesion. following fixation. RS-10, BLOCK suMMARy: B1,B2 - upper outer quadrant; B3,B4 - upper inner quadrant; B5,B6 - lower inner quadrant; B7,B8 - lower outer quadrant; B9 - central breast; B10 - nipple. C. Received fresh (excised at. received at placed in formalin at in a container labeled "left breast" is a 20.5 cm. from superior to inferior x 18.8 cm from medial to lateral x 3.2 cm from anterior to posterior soft tan-yellow mastectomy specimen, with an orienting suture present. On the anterior surface there is a 7 x 5 cm
+
+--- Page 4 ---
+tan-white skin ellipse, with a centrally located 1.2 x 1.2 x 0.5 cm nipple.  The intact deep margin is inked, and the specimen is serially sectioned. There is a circumscribed 3.2 x 2.9 x 1.8 cm rubbery tan-white mass within the upper outer quadrant. The lesion is 1.1 cm from the deep margin, and 1.3 cm from the anterior surface, which is subsequently inked blue. The specimen away from the nodule consists of interspersed yellow adipose tissue and tan tissue, without additional focal lesion. RS-12, following fixation. BLOck sumMARy: C1-c3 - tumor to anterior surface; C4,c5 - tumor to deep  c8 - upper margin; c6 - central tumor; c7 - upper outer quadrant; inner quadrant; c9 - lower inner quadrant; cio - lower outer quadrant; c11 - central breast; C12 - nipple. D. Received fresh in a container labeled "left axillary contents" is a 6.5 x 6.3 x 2.4 cm aggregate of yellow lobular fatty tissue which has a multiple lymph nodes, up to 3.5 cm in greatest dimension. Rs-9, following fixation, with all lymph nodes submitted, from superior to inferior, with the superior-most lymph node in block D1, four lymph nodes in block D2, five lymph nodes in block D3, three lymph nodes in block D4, one sectioned lymph node in blocks D5 & D6, four lymph nodes in block D7, one lymph node in block D8, and three lymph nodes in block D9. dilteal disee 3/15|13
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diff --git a/output/text/c215895a-e5dc-430c-8b90-dc26d228aa2d.txt b/output/text/c215895a-e5dc-430c-8b90-dc26d228aa2d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4b2b821f9fdb0e7d821167d6d99dce0af12ae25d
--- /dev/null
+++ b/output/text/c215895a-e5dc-430c-8b90-dc26d228aa2d.txt
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+
+--- Page 1 ---
+I0D-03 Date of surgery : 8772/3 ChsroisL Cw9.3 Right eye enucleation je No5 C69.9 Macroscopy The enucleation specimen measures 25 mm in diameter. It includes a segment of optic nerve. of 10 mm associated to 25 mm of fat tissue .At the section, a large black tumor of the posterior pole is found, measuring 16 by 13 mm. Samples have been made for cryopreservation and for cytogenetic studies. Microscopy The tumor described macroscopically correspond to a melanoma. It is made mostly of fusiform cells with ovale nucleus most often nucleolated. Mitotic figures are present (4 mitosis by 10 fields at the 400 magnification).Absence of necrosis or microcalcification.The tumor is developed immediately behind the ciliary body which is sometimes infiltrated. The internal third of the sclera is infiltrated. The iris and the anterior chamber as well as the optic nerve on its entire course and the meningeal sheaths are free.. Conclusion Melanoma with fusiform cells developed behind the ciliary body which is infiltrated sometimes on the entire thickness. Size of the tumor: 16 mm main line Extension to the internal third of the sclera without extrascleral extension The iris and the anterior chamber as well as the optic nerve on its entire course and the meningeal sheaths are free. UUID: 816380AA-CC87-4221-B41C-9A02E2201D02 Redacted lw 12/30/13. 22
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diff --git a/output/text/c226f5b5-1b13-4dfc-bcf0-90fb261668a4.txt b/output/text/c226f5b5-1b13-4dfc-bcf0-90fb261668a4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2eebcd5b3382ac62f5c0a7536d9e77769b691b5c
--- /dev/null
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+
+--- Page 1 ---
+Resident: Pathologis PATHOLOGIC DIAGNOSIS: SPECIMEN LABELED "RIGHT HEMICOLECTOMY": DIFFERENTIATED (3.0 cm in greatest dimension) Tumor is located in the cecum/ascending colon, forms a polypoid mass, is ulcerative and has an infiltrating border. Tumor invades through muscularis propria and into pericolonic adipose tissue. Proximal, distal and radial resection margins are negative for tumor.. Invasive tumor is 9.9 cm from proximal resection margin, 9.5 cm from Lymphovascular invasion is not identified. Venous invasion is not identified. Perineural invasion is not identified.. Pexitumoral lymphoid response (including Crohn's-like infiltrate) is mild. Residual adenoma is absent.. REGIONAL LYMPH NODE (POSITIVE/TOTAL): ZerO (0) / thirty (30).) One (1) separate adenoma. Mural pigment consistent with tattoo site. Associated diseases include diverticulosis. Appendix and terminal ileum with no significant pathologic change. AJcc Classification T3 NO MX. NOTE: Levels examined on block A5.. CLINICAL DATA: History: None given. Operation:  None given. Operative Findings: None given. clinical Diagnosis: Colon cancer. TISSUE SUBMITTED: A/1. Hemicolectomy. GROSS DESCRIPTION: The specimen is received in formalin, labeled with the patient's name, unit ileum (2.2 x 2.8 cm), and attached cecum and ascending colon (20.3 cm in length x 4.5 cm in diameter),.  and attached appendix (5.0 x 0.8 cm), a 3.2 cm proximal  An ulcerated mass (3.0 x 2.2 x 0.5 cm) is present in the cecum/ascending colon, 6.5 cm distal to the ileocecal valve, 9.9 cm from the proximal stapled resection margin, and 9.5 cm from the distal staple resection margin. Approximately 15 to 0.5 cm in greatest dimension, and they may actually represent hyperplastic folds of mucosa. Representative sections of normal mucosa and tumor are submitted for tissue bank. Radial margin is 7.2 cm from the mass. Occasional diverticula are present, with impact of fecaliths. An area of submucosal tattoo pigment is identified 1.8 cm proximal to the mass. Micro Al: Proximal resection margin (en face), 1 frag, Micro A2: Distal resection margin with diverticulum (en tace), 2 frags, Page: 1 of2
+
+--- Page 2 ---
+Pathology Report Micro A3: Appendix tip, 2 frags, Micro A4: Appendix cross sections, frags, Micro  A5-A7: Mass, 1 frag each, Micro A8: Tattoo site with mucosal polyps, 3 frags Micro  A9-A10: Mucosal fold/polyps, 3 frags each, Micro A11: 1 lymph node, 2 frags, 4 frags each, Micro A20: 3 possible lymph nodes, 3 frags, CASE NUMBER: By his/her signature below, the senior physician certifies that he/she personally conducted a microscopic examination ("gross only" exam if so stated) of the described specimen(s) and rendered or confirmed the diagnosis(es) related thereto. Electronically signed on Addendum: Upon re-review of this case, there is a focus of possible invasion into a venule outside of muscularis propria. In that focus, a tumor cell nest is surrounded by discontinuous smooth muscle cells, which probably represent residual venular wall. Addendum #1 by Electronically signed on Addendum #2: This primary tumor is still classified as T3.  The focus mentioned in the previous addendum is suspicious for extramural venous invasion. Addendum #2 by Electronically signed on Page: 2 of 2
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diff --git a/output/text/c22c9797-20bb-4421-a692-febe174beb52.txt b/output/text/c22c9797-20bb-4421-a692-febe174beb52.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1fbc09d759519a790e443ee1b9aa4b677d475352
--- /dev/null
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+
+--- Page 1 ---
+UUID:F47FE6A0-1095-45DD-8CEF-33363FA9F52F TCGA-CC-A9FS-01A-PR Redacted Clinical Case Report IDo-3 87 Sit:ower cxx.0 J 41z[147 Informed Consent I personally informed this patient that a specimen(s) would be collected to be used for research purposes.I reviewed the. RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution.  * 2 Name of Physician or Study Coordinator. gnature Date Clinical Information GENERALINFORMATION Date of Birth (mm/dd/yyyy) Height Marital Status  Race Temperature  Single Married VETNAMESI Gender Weight  Divorced  Widow  Blood Pressure Heart Rate Male  Female PHNSAMHISTORYOFPRESENTILLNESS Chief Complaints: Ti<ec oy. eoctircy j b-lvccthgy j` Jeuer Symptoms: Weight- lcs Clinical Findings: Performance Scale (Karnofsky Score):.  100 Asymptomatic   80-90 Symptomatic but Fully Ambulatory 60-70 Symptomatic, in bed less than 50% of day  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden  20-30 Bed Ridden CURRENTMEDICATIONS : ... Drug Dose  Route Frequency Date (mm/dd/yyy) To To To 1 To 1 To
+
+--- Page 2 ---
+PASTMEDICALHISTORY  Diagnosis Date Treatment Status Diagnosis/Disease/Disorder/Injury WOROBGYNHISTORY Menopausal Status Date of First Menses # of Pregnancies  Pre-menopausal  Peri-Menopausal Date of Last Menses # of Live Births  Post-menopausal Birth Control:  Condom  Oral Contraceptive  IUD  Hormone Replacement Therapy:  Other: RDALRNSOCIALHISTORYACGDA 1 Occupation: Environmental Hazards: Smoking History Current Status TYPE  Packs/day Duration When Quit ***  yes NO (yrs) (yr) Alcohol Consumption Current Status TYPE Drinks/day Duration When Quit   nO Adind Idauy SYES yrs u(yr) Drug Use Current Status TYPE Frequency Duration When Quit O YES  NO (yrs) (yr ANOERFAMILYMEDICALHISTORYAU Relative Diagnosis Age of Diagnosis RLABDATARA Test Result Date Test Result Date HIV  Positive: CEA Negative   Negative  Positive: Hep B Negative  Positive: CA 15-3   Negative  Positive: Negative Hep C CA 19-9  Positive:   Negative  Positive: AFP  Negative  Positive: PSA   Negative  Positive: Other: Other:  Negative  Positive:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+OTWwDIAGNOSTIGSTUDIES.SAHMERSA Date Study Results tho Live Ultrasound  A tmwwt Was X-Ray CT Endoscopy MRI Biopsy Preoperative Clinical Diagnosis Location of Suspected Involved Lymph Nodes Location of Suspected Distant Metastasis Date of Diagnosis Clinical Staging T2 NO MO Stage: 7 Treatment Information SURGICALTREATMENTA Date of Procedure. Procedure Reseetim ol tte lot-liver Primary Tumor  Detailed Location Size Organ 3x 3 x 2 cm Liver ZcemoR Jett LigeR Extension of Tumor Lymph Nodes # of Lymph Nodes Description Location of Lymph Nodes Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Detailed Location Size Organ Surgical Staging t 2 No m 0 Stage:T NEOADJUVENTTHERAPY (ChemoRadiation ImmunoHormonal Molecular Frequency Date (mm/dd/yyyy) Drug/Treatment Dose Route To To 1 1 1 1 To 1 / To 1 1 To 1 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by: Date: Time Preserved by: Date: Time: xaSPECIMENTYPE #of.samples provided.w.w Paraffin Biock Blood/Serum/Plasma Slide Frozen Normal Diseased Normal Diseased Normal Diseased Normal Diseased 2. 2 4 'Time to LN2 Time to LN2 Time to Formalin (3 min min o 12  min TPATHOLOGICALDESCRIPTIONTOAP Primary Tumor Organ Size Extension of Tumor  Distance to NAT Li xek JmeR. 3 x3 x2 cm eLt/ineR cm Lymph Nodes # Examined # Metastasized Location Distant Metastasis Organ Detailed Location Size Pathological Staging NO m 0 Stage:  pT 2 Notes: 4
+
+--- Page 5 ---
+Consolidated Pathology Diagnosis CaH Distribution + Sructarre! Pattern Diffuse 4.1 Streaning  Mosaic Storform Necros's. Fbrosis Lymphocytic Infitration adino Vascutar Invasion Oystic Deeneration Clusterized Bleeding Alveolar Formation Mexxoid Chanoe Indian File Peammorna/C Bickication Sgusn mous + Adarsormatousn + Sarcometou L ymohomntous Sauamold Cell Glandutar cel x Round Cell Laroe Cel Spindie Cell Cell Stratfication Fibrobiast SmaA Cej Keratin Secretion Osteoblast  RS Cea/rs Like Desmosome Intacyt. Vacuole Lipoblast Irflarn. Cell Penrt Gland formation Myobiast  Plasma Cel Cellular Difforentiation: o Wek A Moderate  Poor Nuciear Atyoiu: 0 I m Aniso Nudeosis Ityperchromatisn.  Nucieotar Prominent Muitinucieated Glont Cel!d Mitotic Activity Nuciear Grade: Fina! Pathology Report Srlsd- Iabeesstar trie Comments: Date Director, Research Pathology hs 1/3/ INTEGRATED REPORT OF FINDINGS BY COLLABORATORS AND PATHOLOGISTS Primary Tumor Site Discrepancy Dual/Synchr ase is c DISQUAUFIED
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diff --git a/output/text/c28f94b9-ef1e-447e-b716-8cb7270bf75d.txt b/output/text/c28f94b9-ef1e-447e-b716-8cb7270bf75d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8a5f0838bccbb40b14372aaa6c9f23bba2d0175d
--- /dev/null
+++ b/output/text/c28f94b9-ef1e-447e-b716-8cb7270bf75d.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:D98244DA-ED34-47B3-A5DD-ECED56C07891 TCgA-2Z-A9Je-01A-PR Redacted ZD -3 arsintmo, ypaplsry Menee a0Q 8Q60f3 Pathology Report Site:R Bislnwy NsS Cb49 Final Diagnosis sO 4/z8/14 A. "SKIN LESION X3 RIGHT FLANK,* EXCISION: Two seborrheic keratosis, both involving inked surgical margin.. One lichenoid keratosis, completely excised. B. RIGHTKIDNEY,BIOPSY: Fibroconnective tissue with atrophic renal tubules and focal mild chronic inflammation, negative for malignancy C. *RIGHT RENAL MASS,* HEMINEPHRECTOMY: Renal cell carcinoma, papillary type 1, Fuhrman nuclear grade 2 of 4.. Two papillary adenomas, each measuring less than 1 mm.. Portion of adrenal gland with no significant pathological change.. See Key Pathological Findings. D. RIGHT ADRENAL GLAND, ADRENALECTOMY: Adrenal gland with hemorrhage, negative for malignancy. I the attending pathologist, personally reviewed the entire case and rendered the final diagnosis. Electronically Signed Out by Key Pathological Findings Tumor type: Renal cell carcinoma, papillary type 1. Nuclear grade: Fuhrman nuclear grade 2 of 4. Pattern of growth: Papillary. Tumor size: 4 cm. Invasion through Renal capsule: Not identified. Invasion of Gerota's Fascia: Not applicable. Renal vein invasion: Not applicable. Surgical margins: Free. Non-neoplastic kidney: Focal mild chronic inflammation, glomerulosclerosis, and. tubular atrophy. Adrenal gland: Not involved. Lymph nodes: Not applicable. Pathologic stage: pT1aNXMX. Specimen(s) Received A 3 LESIONS RIGHT FLANK - GROSS EXAM B RENAL BX - RIGHT KIDNEY FS c RIGHT RENAL MASS FS D ADRENAL - RIGHT Clinical History Right renal mass.
+
+--- Page 2 ---
+Preoperative Diagnosis Mass right kidney. Intraoperative Consultation A. SKIN LESION X3RIGHT FLANK, GROSS EXAMINATION: Grossly benign. FSB1.  RENAL BIOPSY RIGHT KIDNEY:  Benign fibromuscular tissue with focal inflammation. Na evidence of malignancy. FSC1. RIGHT RENAL MASS: Papillary renal cell carcinoma, inked margin is free of tumor. Comment: These gross and frozen section diagnoses/results were communicated to and acknowledged by have performed the intracperative consultations and issued the above  diagnoses. Gross Description A. Specimen A is labeled *skin lesion x3 right flank". The specimen is received fresh and consists of an unoriented, gray-tan, wrinkled ellipse of skin with attached subcutaneous tissue (4.5 x 1) excised to a depth of 1 cm. There are 3 lesions on the epithelium surface ranging from 0.2 cm to 0.6 cm in greatest dimension. The specimen is marked with blue ink on one half and green ink on the opposite half. The remainder of the cut surface is grossly unremarkable. No tissue is submitted to Tissue Procurement Laboratory. Permanent representative sections are submitted as: A1: Both tips A2: Lesion Na. 1 largest A3: Lesion No. 2 A4: Lesion No. 3. B. The specimen is received fresh for OR consult, labeled *renal biopsy right kidney, frozen. section*. The specimen consists of a 0.7 x 0.5 x 0.2 cm, soft, red-brown, irregular fragment of tissue which is entirely submitted as frozen section as FsB1. C. The specimen is received fresh for OR consult, labeled *right renal mass,frozen section margins and diagnosis". The specimen consists of a moderately firm, red-brown, irregular, renal mass which consists of normal renal parenchyma and adipose tissue measuring 6 x 5 x 4.5 cm in overall dimension. The surgical margin of resection is marked with black ink and the renal capsule with adipose tissue is inked biue. Sectioning reveals a soft to somewhat firm yellow-brown, necrotic, partially hemorrnagic mass (4 x 3.5 x 3.3 cm). The mass is located approximately 1.2 cm from the surgical margin of resection. Grossly, the mass does not appear to infiltrate the capsule. The remaining renal parenchyma is grossly unremarkable. Additional sectioning isolates what grossly appears to be a portion of the adrenat gland measuring 2 cm in its greatest dimension. No tissue is submitted to the Tissue Procurement Laboratory. Representative sections are submitted as follows: FSC1: Frozen section of renal mass with inked parenchymal margin
+
+--- Page 3 ---
+(perpendicular section) C2-C8: Representative section of renal mass C9: Grossly unremarkable renal parenchyma C10: Possible adrenal glande C11: Attached perinephric adipose tissue. D. Specimen D is labeled "right adrenal*. The specimen is received fresh and consists of a 14.1 gm, 7 x 2.5 x 2.5 cm, soft to somewhat firm yellow-tan tissue which is entirely marked with black ink.. Serial sections reveal a bright orange peripheral focus with a hemorrhagic center measuring 3.5 x 2 x. 1 cm. The remainder of the cut surface is grossly unremarkable. No tissue is submitted to the Tissue Procurement Laboratory. Permanent representative sections are submitted as: D1-D3: Adrenal gland with a hemorrhagic center D4: Additional section of adrenal gland. Mv y3/l4 DISQUALIED?
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diff --git a/output/text/c296744c-dfec-4f74-bee4-792cfdf3134a.txt b/output/text/c296744c-dfec-4f74-bee4-792cfdf3134a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..10218ffcb3545988c63717eb7dcd799883a9a72a
--- /dev/null
+++ b/output/text/c296744c-dfec-4f74-bee4-792cfdf3134a.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Pathology Report DIAGNOSIS A) LEFT KIDNEY AND ADRENAL GLAND: CHROMOPHOBE RENAL CELL CARCINOMA, FURHMAN'S NUCLEAR GRADE 3. TUMOR CONFINED TO THE KIDNEY. TUMOR MEASURES 18.0 X 16.0 X 8.5 CM. LYMPHATIC/VASCULAR INVASION PRESENT. Vascular, ureteral and soft tissue margins of resection free of tumor.. Four lymph nodes, no tumor present (0/4). Adrenal gland, no tumor present. B) PARA-AORTIC LYMPH NODES: Five lymph nodes, no tumor present (0/5). GROSS DESCRIPTION (A) LEFT KIDNEY AND ADRENAL GLAND - A nephrectomy specimen (21.0 x 16.0 x 9.0 cm) including a small rim of remaining normal kidney (5.0 x 3.0 x 2.0 cm), a segment of renal artery, renal vein, and ureter (17.0 cm in length x 0.4 cm in average diameter), and fragments of the adrenal gland (4.0 x 3.0 x 1.0 cm in aggregate).. There is an 18.0 x 16.0 x 8.5 cm well-circumscribed tumor replacing the majority of the kidney and leaving only a small. remaining inferior/lower pole of kidney. The tumor is pink-tan with extensive areas of hemorrhage (5.0 x 2.5 x 2.0 cm) and. necrosis (9.0 x 8.0 x 7.0 cm), which is predominantly within the center of the tumor. The tumor is confined to the kidney and does not invade sinus adipose tissue or the renal vein. The tumor does not extend into Gerota's fascia. The adjacent kidney parenchyma is unremarkable. The pelvicalyceal system is smooth and devoid of any lesions. Four lymph nodes are identified within the hilum of the kidney, all measuring approximately 2.0 cm. Serial cross-sections of the adrenal gland fragments show unremarkable cortex or medulla.. Portions of the tumor have been submitted for possible electron microscopy. Sections of tumor and normal kidney have been submitted to the tumor bank. Photographs of the specimen have been taken. INK CODE: Black - Gerota's fascia. SECTION CODE: A1, renal artery, vein and ureter margins, en face with one lymph node; A2, section of adrenal gland; A3-A5, tumor with capsule; A6-A8, tumor with normal kidney; A9-A11, tumor with necrosis; A12-A13, tumor with pelvis; A14, normal kidney; A15, one lymph node; A16-A17, one lymph node; A18-A19, one lymph node. (B) PARA-AORTIC LYMPH NODES - Five lymph nodes are identified, ranging from 0.5 x 0.4 x 0.3 cm to 2.5 x 1.0 x 0.8 cm. SECTION CODE: B1, three lymph nodes; B2, one lymph node serially sectioned; B3, one lymph node.. CLINICAL HISTORY Left renal mass SNOMED CODES
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diff --git a/output/text/c2be98c7-3c11-4766-b985-19426f080489.txt b/output/text/c2be98c7-3c11-4766-b985-19426f080489.txt
new file mode 100644
index 0000000000000000000000000000000000000000..60056e7842928a47203019a4850be74972586b1f
--- /dev/null
+++ b/output/text/c2be98c7-3c11-4766-b985-19426f080489.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+Patient Name Accession #: Med. Rec. #: Date of Procedure DOR Date of Receipl Gendor: Date of Report: Ref.Physician. Account #: Patient Address Billing Type: Additional Copy lo. Ret. Source Clinical Diagnosis & History: Lell renal mass with thrombus, left kidney tumor.. Specimens Submitted: 1: SP: Caval wall, biopsy 2: SP: Kidney and adrenal gland, loft, radical nephreclomy. 3: SP. Vena cava, additional, biopsy 4: SP: Lymph nodes, lelt perihilar, resection 5 SP:Lymph nodes, paraaortic, resection 6: SP:Lymph nodes,  aortocaval, rosection 7: SP: Hermia sac. abdomen, repair DIAGNOSIS: 1. SP: Caval wall, biopsy -Portion of vein with a detached cluster of atypical cells admixed with fibrin in the lumen (see comment) 2. SP: Kidney and adrenal gland, left, radical nephroctomy:. Tumor Type: Renal cell carcinoma, unclassified, with papillary features and high nuclear grade (see comment) Tumor Size: Greatest diameter is 8.5 cm. With multiple satellite nodules Local Invasion (for renal corical types) Extends through renal capsule but contined within Gerota's fascia Extends into renal pelvis Involves renal hilar fat Renal Vein Invasion: Identified Extensive vascular invasion is present Surgical Margins: Tumor present at ronal vein margin Non-Neoplastic Kidney: Unremarkable  Renal papillary adenoma (0.2cm in greatest dimension). Adrenal Gtand: Carcinoma invoives Ihe periadrenal soft lissue and abuts the capsule of the adrenal gland 1.ymph Nodes: Page 1 0t 5
+
+--- Page 2 ---
+Not identified Slaging for renal cell carcinoma/oncocytoma:  pT3b Tumor grossly extends into the renal vein(s) or vena cava below the diaphragm. 3. SP: Vena cava, additional, biopsy:. -Portion of vein with detached atypical cells admixed with fibrin in the lumen, favor reactive: no definite tumor seen (sce comment) 4. SP: Lymph nodes, left perihilar, resection: Lymph Nodes:  Number of nodes examined:10 Number of metastatic nodes:8 The largest metastatic node is 2.5cm  Perinodal (extracapsular) extension identilied The largest metastatic deposit neasures 2.Scm in greatest dimension 5.  SP:Lymph nodes, paraaortic, resection: Lymph Nodes:  Number of nodes examined:18 Number of metastatic nodes:13. The largest metastatic node is 3.5cm Perinodal (extracapsular) extension identified  The largest melastalic deposit measures 3.5cm in greatest dimension SP:Lymph nodes, aortocaval, resection: t.ymph Nodes: Not involved Number of nodes examined:4 7. SP: Henia sac, abdomen, repair: -Benign mesothelium lined fibrovascular and adipose tissue, consistent with hernia sac. Comnenl: The lunor cells are negative for CK7, 34BE 12 and racemase, and show focal faint staining with AE1/AE3 and CA-IX. BAF-47 slain is non-contribulory.Among the diagnoslic po ditary leiomyoma renal cell carcinona (HLRCC) should be considered. Selected parts (1, 2, 3 and 5) reviewed witl who concurs. Some of the immunohistochemistry and ISh tests were developed and their performance characteristics were determined by the Department of Pathology. They have not been cleared or approved by the US Food and Dnug Administration. The FDA has determined that such clearance or approval is not necessary. These lesls are used for clinical purposes. They shouid not bo tigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments ol  qualified to perlorm high complexity clinical laboratory testing. IAT IEST THAT THE ABOVE OIAGNOSIS IS BASED UPON IAY PERSONAL EXAMAINATION OF TH REVIEWED AND APPROVED THIS REPORT Special Studies: Result Special Stain Comment AE1:AE3 CK7 Page 2 of 5
+
+--- Page 3 ---
+RACEMASE 34BE12 NEG CONT IMM RECUT BAF-47 CA-1X.  NEG CONT Gross Description 1)The specimen is received fresh for frozen section consultation, labeled "caval wall rule out lumor invasion" and consists ol tan-pink tissue measuring 0.9 x 0.4 x 0.1 cm. Entirely submilted for trozen section Summary of sections F$C -- frozen section control 2) The specimen is received fresh and subscquenlly placed in formalin labeled "left kidnoy and adrenal gland, fresh and sterile" and consisis of a kidney with attached ureter, renal vessels and perinephric fat weighing 1007 g in total. The kidney measures 19 x 12.5 x 8.5 cm. The atlached ureter measures 9 cm in length and 0.2 cm in diameter. Tho attached renal vein measures 5.5 cm in Jengih and 1.7 cm in diameter. The arterial and ureteral margins are grossly unremarkable. The vein is dilated with frm. adherent, yellow-red possible blood clot obstructing the lumen. Aiso in the pelvis are multiple firm to rubbery nodules, some of which appear lo be positive lynph nodes. An orange-yellow. hemorrhagic adrenal gland is identified near the hilum and measures 5 x 3 x 1.5 cm. The kidney is inked black and bivalved to reveal an 8.5 x 7.5 x 6 cm yellow-tan to red-brown, henorrhagic, friable, pseudoencapsulated mass in the upper pole which grossly invades through the renal capsule. Scattered are mulliple ovoid, circumscribed lesions which grossly involve the pelvis. Sections through the remainder of the kidney reveals scant. uninvolved  pink brown parenchyma, with a well-defined cortico-medullary junction. The cortex measures up to 1.2 crn and the calyces are almost entisely intiltrated with tumor. Also in the container are multiple, irregular portions of red-yellow, friable, possibly necrotic soft tissue and red-brown blood clot representing possible at. eiditional portions of the upper pole tumor. The specimen is photographed. Representative seclions are submitted fo. d for permanenl sections. Summary of sections: UVM -- ureteral and vessel margins UPT-- upper pote tumor THF-- tumor with hilar fat TSF -- tumor with sinus fat UPTK - upper pole tumor with adjacent kidney RP -- renal pelvis representative sections K -- representative sections kidney  AD -- adrenal gland- 3) The specimen is received in lormatin, labeled "Additional vena cava" and consists of a 1.2 x 0.4 x 0.3 cm, inregular, rubbery,. pink-white tissue fragment, which is submitled in toto. Summary of scctions. AVC -- additional vena cava 4) The specinen is received in formanr Lell pemmar lymph nodes and consists af a 2.4 x 2.0 x 1.3 cm from of a tissue. fragment, which is sectioned to reveal five, firm, red purple lymph nodes, ranging from O.3 to 2.2 cm in greatest dimension. The larger lymph nodes are bisected or trisecied and ail lymph nodes are entirely submilted.. Summary of soctions: LN -- lymph nodes BLN -- bisecled lymph nodes I TLN -- largest lrisected lymph node, submilled into two cassettes. Page 3 of 5
+
+--- Page 4 ---
+ara-aorlic lymph nodes" and consists of a 3.7 x 3.6 x 2.0 cm aggregate of  fibrofatly tissue, which is seclioned to reveal 19, frm, slightly adhered to matted, tan-white lymph nodes, ranging from 0.3 to 2.6 cm  in greatest dimension. The targer lymph nodes are hisected and all lymph nodes are entirely submitted. Summary of sections: LN -- lymph nodes BLN -- bisected lymph nodes 1.BLN -- largest bisected lymph node, submitted into two cassettes 6) The specimen is received in formalin, labeled "Aortocaval lymph nodes" and consists of a 2.6 x 1.1 x 0.7 cm librolally tissue fragment, which is sectioned to reveal four, diffusely hemorhagic, focally fragmented, tan-red lymph nodes, ranging from 0.7 to 1.2 cm in grealest dimension. All four lymph nodes are bisected and are entirely submitted. Summary of seclions: BLN -- bisected lymph nodes focally falty, tan-purple fibromombranous tissue iragment. wilh mulliple congested lobules of adipose tissue. No lesions or lymph nodes are identified grossly. Representative sections are subnilled. Summary of sections:  RS -- representative section Summary of Sections: Part 1: SP: Caval wall, blopsy Block Sect. Site PCs fsc 1 1 1  Part 2:  SP: Kidney and adrenal gland, left, radical nephrectomy Block Sect. Site PCs r N AD 2 K 3 LN 3 1 PTK 3 RP 4 SL 4 1 THF N TSF 2 4 UPT 4 2 UVM 3 Part 3:  SP: Vena cava, additional, biopsy Block Sect. Site PCs 1 AVC i 1 Part 4: SP: Lymph nodes, left perihilar, resection Block Sect. Sito PCs 2 BLN 4 2 LBLN N N 1 LN  Part 5: SP:Lymph nodes, paraaortic, resection Page 4 of 5
+
+--- Page 5 ---
+Block Sect. Site PCs 6 BLN 12 2 LBLN 2 2 LN 12 Part 6:  SP:Lymph nodes, aortocaval, resection. Block Sect. Site PCs 4 BLN 8 Part 7: $P: Hornia sac, abdomen, repair. Block Sect. Site PCs 1 RS ? Intraoperative Consultation: Note: The diagnoses given in this section perlain only to the tissue sample examined at the tine of the intraoperalive consultation. 1) FRO2EN SECTION DIAGNOSIS: SP: CavaI wall PERMANENT DIAGNOSIS: SEE FINAL Page 5 of 5 END OF REPORT
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diff --git a/output/text/c2d5d2b7-3522-456b-9b30-23c693b465f2.txt b/output/text/c2d5d2b7-3522-456b-9b30-23c693b465f2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f4dd182aec83e39ecb124239ebd95c35c6659669
--- /dev/null
+++ b/output/text/c2d5d2b7-3522-456b-9b30-23c693b465f2.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:B874087C-F4C7-456F-AC63-E17A98F1666F TCGA-A4-A6HP-01A-PR Redacted Sex: Male D.O.8.: MRN # EOARSAAECSPEEIMENANPO Collected: Received:  Reported: SURGICAL PATHOLOGY REPORT *ADOENDUM** ADDENDUM REPORT: Per Dr. This addendum is issued to clarify the surgical margins status. This case was discussed with Dr. the specimen submitted as deep margin (B) was taken from the left lateral tumor (specimen C). The left lateral tumor is not transected in the histoogic  sections examined. Multiple satellite foci (greater than 10) are noted in the renal parenchyma surrounding the three main lesions in specimen C-E. Some of these satellite lesions measure less than 1 mm. Therefore it is possible that the deep margin tumor in specimen B represents a separate focus of also raveals that the upper pole tumor (D) was adherent to the specimen submitted as left cyst wall (A). The upper pole tumor showed an aiea or capsular  retraction with ink focally extending to the turnor. This additional information from Dr.. Jakes it likely that this area of concem was the site of the. adherent cyst and therefore does not represent a true margin.  In summary, no tumor transection is noted, however, this patient is at increased risk for recurrence due to the numerous small satellite lesions noted. Addendum Reoort Issued Bv: DIAGNOSIS: ICDO-3 A. Left cyst wall; excision:. Simple cyst wall, negative for malignancy. B.Deep margin: 15248B Papillary renal cell carcinoma.. semo c00 C. Left lateral tumor, resection: Sete Idney NOS Tumor Characteristics: . Histologic type: Papillary renal cell carcinoma. Cb49 2. .Tumor site: Left lateral kidney. .Tumor focality: Multifocal. s[12|T3 4. Size af largest tumor focus: 2.9 x 2.6 x 2.1 cm. 5. Macroscopic extent of tumor: Tumor limited to kidney 6. Microscopic extent of tumor. Tumor limited to kidney.. 7. Nuclear grade: Fuhrman grade 2 of 4. 8. Lymphovascular space invasion: Not identified.. Surgical Margin Status: 1. Soft tissue surgical margins free of tumor, see specimen B for separately submitted deep margin Lymph Node Status: .No lymph nodes received with specimen. Other: 1. pTNM stage: pT1a, NX. D. Upper pole tumor, resection: Papillary renal cell carcinoma, 1.8 cm in greatest dimension, multifocal.. Tumor focally extends to inked capsular surface, see comment. E. Lower pole tumor, resection: Papillary renal cell carcinoma, 2.5 cm in greatest dimension, multifocal.. Surgical margins free of tumor. Electronic Signature:
+
+--- Page 2 ---
+Histologic sections show numerous foci of papillary renal cell carcinoma. Each of the resections including the left lateral, upper pole, and lower poles  excisions demonstrate a dominant primary tumor with multiple smaller foci within the adjacent renal parenchyma. The separately submitted deep margin (specimen B) also damonstrates similar morphology consistent with papillary renal cell carcinoma. The cyst wall is negative for tumor.  Specimen  (upper pole tumor) demonstrates tumor extending to the inked outer/capsular surface, however the capsule appears to have retracted in this  area and the presence of ink at the tumor is interpreted as a retraction artifact and not a true positive capsular/soft tissue margin. TSSSSACAKSASKKCLNICAL INFORMAUIONRAACARSEOSKNMLANS CLinICAL HIstory: Preoperative Diagnosis: Left renal cyst, left renal mass. Postoperative Diagnosis: Symptoms/Radiologic Findings: SPECIMENS: A. Left cyst wall B. Deep margin. C. Left lateral tumor D. Upper pole tumor E. Lower pole tumor SADOCSASPECRENDAIASASSSANAK GROSS DESCRIPTION: A. Received in formalin labeled. ind leit cyst wall is a 4.2 x 1.5 x 0.2 cm irregular piece c*. mhranous tissue consistent with cyst wall. On section a lesion is not identified. Representative sections are submitted in one cassett?. B. Received in formalin labeled. and deep margin is a 0.2 cm pink fragment submitted intact in one cassette. C. Received in formalin labeled. and left lateral tumor is a 24.4 gram wedge of renal tissue, 4.5 x 3.2 x 1.8 cm. The resection margin is. inked blue and the soft tissue aru capsuie yellow. The specimen has been previously incised for research. Further section displays a circumscribed soft yellow lesion, 2.9 x 2.6 x 2.1 cm. The lesion is 0.2 cm trom the resection margin and abuts the inked capsule. The remainder of the tissue is smooth homogeneous tan renal parenchyma.  Representative sections are submitted as follows: 1-2--perpendicular section through resection margin bisected; 3-4--perpendicular section through $ection margin bisected; 5--representative sections through perinephric adipose tissue.  wo cassettes for research are labeled D. Received in formalin labele. ind upper pole tumor is a 4.9 gram wedge of renal tissue, 3.8 x 2.0 x 1.6 cm. It is covered by a smooth  capsule inked black. The resecuon margin is tan-pink shaggy and displays a 1.5 cm long by 0.9 cm in diameter disrupted cyst. The resection margin is inked blue. The specimen is serially sectioned to display a circumscribed focally nemorrhagic yellow bulging nodule, 1.8 x 1.5 x 1.5 cm. It is 0.2 cm from  the cyst and less than 0.1 cm from the inked capsule and resection margin. The uninvolved tissue is tan-brown smooth and homogeneous. The entire  specimen is sequentially submitted in four cassetter. E. Received in formalin labeled. and lower pole tumor is a 12.5 gram wedge of renal tissue, 5.4 x 3.5 x 2.5 cm. The specimen is covered by a complete, intact capsule. The resection margin is tan-brown and homogeneous. The capsule is inked black and the resection margin blue. The  specimen is serially sectioned to show a focally hemorrhagic pale yellow soft circumscribed lesion, 2.5 x 2.1 x 1.6 cm. The lesion abuts the capsule and is 0.3 cm from the resection margin. The uninvolved tissue is tan-pink and homogenous. Representative sections to include perpendicular sections through the resection margin are submitted in four cassettes, l d10|13
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diff --git a/output/text/c2ee198f-a751-43c0-a422-ae41c02504f6.txt b/output/text/c2ee198f-a751-43c0-a422-ae41c02504f6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..dc9fa1a2ac251977989cbd583cafa257957603d9
--- /dev/null
+++ b/output/text/c2ee198f-a751-43c0-a422-ae41c02504f6.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+ath (First Tumor) Tumor Site: Cecum Proximal Date of Cancer Sample Procurement: Histology: Adenocarcinoma Description of other histology: Grade: Moderately Differentiated C Yes Mucinous: 6 No  Yes C Unknown (Focal) r Yes Signet Ring Feature: 6 No r Yes C Unknown (Focal) Histologic Heterogeneity: 6 No ( Yes C Unknown Host Response: Lymphoid Aggregates Crohn's like reaction ( None  Yes C Unknown Plasma cell rich stroma r No  Yes C Unknown  Expansile  Expansile Growth Pattern:  Invasive C Unknown  and Invasive Inflammatory Bowel Disease 6 No ( Yes C Unknown Angiolymphatic Invasion: 6 No ( Yes  Unknown Mutator Phenotype: c No ( Yes  Unknown Number of Slides 1 C Yes Garland Necrosis present: C No  Yes C Unknown (Focal) TIL Cells / HPF 1 Pathologist Comment: 1cs-0-3 8140/3 adenoca ciema, NOs UUID:66BF2525-B76A-48E5-8FDF-EAE8334F384E Site: Cecur- C18.0 p5/3/n TCGA-DM-A28A-01A-PR Redacted se is cl.cle
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diff --git a/output/text/c2ef6a29-61b7-4c39-b7c8-e0f0f6002001.txt b/output/text/c2ef6a29-61b7-4c39-b7c8-e0f0f6002001.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0451f84c3c816ea84b9ddbefe36df9bce0d36c9d
--- /dev/null
+++ b/output/text/c2ef6a29-61b7-4c39-b7c8-e0f0f6002001.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID: F52224B9-1FAF-4F71-B017-22AAEBA8F75D TCGA-G3-A25V-01A-PR Redacted Laboratory Services IcD-0-3 carcinoma hepatv cllulw, nos 817o/3 MRN: PHN: Site : liver. c2a.0 ACB: DOB/Gender: Telephone: Encounter: Surgical Pathology Report Inquiry Numbers: Accession Number: Reraived Date/Time: Specimen Description A. Gal!bladder - FS B. Liver segment 5 Clinical Information Liver mass which looks like hepatoceilular carcinoma; patient has known cirrhosis secondary to alcohol ingestion. Liver Ca. Diagnosis A. Gallbladder: - Chronic cholecystitis B. Liver Segment 5: - Moderately-differentiated hepatocellular carcinoma, 1.5 cm in the greatest dimension. Resection margins are free of tumor. - Cirrhosis Cc: Pathology: Provider - Permanent Page t of 2
+
+--- Page 2 ---
+Surgical Pathology Report Inquiry Numbers: Received Date/Time: Gross Description. Received are specimens A to B. All requisitions and specimen containers are labelled with the patient's name  The cassettes and AP identifiers are labelled with the Surgical Number A. The specimen consists of a gallbladder measuring 10.0 x 3.5 x 1.2 cm. The galibladder is filled with yellow-greenish bile without stonee Th mucosa is velvety and granular. There is no tumor identitied. AgNO3. One random section taken for QS. Three further representative sections of the specimen are submitted in cassette A2. B. The specimen is received fresh and is subsequently placed into formalin and consists of a congested wedge of liver weighing 17.9 grams and measuring 4.0 x 3.0 x 3.0 cm. The resection margin is inked blue. Specimen is sectioned and the liver parenchyma grossly appears to be cirrhotic. Within the specimen is a yellow/tan circumscribed lesion measuring 1.5 x 1.5 x 1.0 cm. Grossly, this lesion comes within 0.6 cm of the blue-painted margin and 0.2 cm through the capsule. The mass is submitted in toto in cassettes B1 to B4. Further representative sections of liver are submitted in cassette B5.. Frozen Section Diagnosis A. Gallbladder: - Negative for malignancy. Cc: Pathology: Provider - Permanent Page 2 of 2 www
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diff --git a/output/text/c3091a8d-5ce2-4c5f-9a48-23bb4a1ae7f5.txt b/output/text/c3091a8d-5ce2-4c5f-9a48-23bb4a1ae7f5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c8557b6fb274b9189b9f2a7a3d7b67c5ab4bbdc6
--- /dev/null
+++ b/output/text/c3091a8d-5ce2-4c5f-9a48-23bb4a1ae7f5.txt
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+
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+Formatted Path Report LARGE INTESTINE TISSUE CHECKLIST Specimen type: Colectomy Specimen size: Not specified Tumor site: Sigmoid colon Tumor size: 5.2 x 2.2 cm Tumor features: Infiltrative, Ulcerated Histologic type: Mucinous adenocarcinoma Histologic grade: Poorly differentiated Tumor extent: Subserosa Lymph nodes: 13/18 positive for metastasis (Pericolonic 13/18) Margins: Uninvolved Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None.
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+Date of Procurement
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+1cs-0-3 Cancima,vnfiI+naHng duct,Nos 85oof3 c50.9 12/2rh hw Sit Cvde: Drenst, NOs ' Final diagnosis Breast, left, wide local excision: Infiltrating ductal carcinoma, Nottingham grade II (of III). [tubules 3/3, nuclei 3/3, mitoses 2/3, Nottingham score 8/9], forming a 1.7 x 1.6 x 1.2 cm mass [AJCC pT1c]. Ductal carcinoma in situ, intermediate nuclear grade, comprising less than 5% of tumor volume. Angiolymphatic invasion is absent. Biopsy site changes present. All surgical resection margins, after re-excisions of the medial and superior margins, are negative for tumor (minimum tumor free margin, 0.9 cm, superior margin). A single intramammary lymph node, present at the medial margin, is positive for metastatic carcinoma. The involved lymph node measures 1.5 mm in maximum dimension.. Lymph nodes, left axillary sentinel, excision: A single (of 2) left axillary lymph node is positive for metastatic carcinoma [AJCC pN1]. Blue dye is identified in both left axillary sentinel lymph nodes. Immunohistochemical cytokeratin stain was performed on the paraffin embedded sentinel lymph node tissue and confirms the H&E impression.. Lymph nodes, left axillary, dissection: Multiple (36) left axillary lymph nodes are negative for tumor. Faxitron done. Estrogen and progesterone receptor analysis and Her-2/NEU have been ordered on paraffin embedded tissue. JUID:37EF1828-0A53-4358-97C7-A7849EC653AF Redacted TCGA-A R-A1A0-01A-PR 11 
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diff --git a/output/text/c322c1f3-6898-4d43-a1e9-a10adf61b4af.txt b/output/text/c322c1f3-6898-4d43-a1e9-a10adf61b4af.txt
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index 0000000000000000000000000000000000000000..8f0d17683ea7db29dbaccd572a331ba756035621
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+UUID:9C29F0C tCDD-3 TCGA-Y8-A897-01A-PR Redacted 'aranomo geapllery renal 8#60|3 Cel 5tD45rdney NOSo49 Research Gross Description female with renal lesion )11122]13 Research Dx Left renal mass, robotic left partial nephrectomy: Papillary renal cell carcinoma, type 2, see summary. CASE SUMMARY FOR NEPHRECTOMY FOR RENAL CELL CARCINOMA: Procedure: robotic left partial nephrectomy and robotic hysterectomy with bilateral salpingo- oophorectomy, regional lymph node dissections. Specimen laterality: left Tumor site: upper pole. Tumor size: 1.8 cm Extent of disease: tumor limited to kidney Histologic type: papillary renal cell carcinoma, type 2. Sarcomatoid features: not appreciated Tumor necrosis: not appreciated Histologic grade (Fuhrman Nuclear Grade): grade 2 Margins: free of tumor Lymphovascular invasion: not appreciated. Pathologic staging (pTNM): Primary tumor: Tumor 4 cm or less in greatest dimension, limited to the kidney. Regional lymph nodes Number examined: 34 Number involved: 0 Distant metastasis: unknown. Pathologic findings in nonneoplastic kidney: none Other tumors and/or tumor-like lesions: none in kidney AJCC Staging (7th edition) pT1a pN0 pM not applicable Research QC Tumor: 66% tumor nuclei. 0% necrosis 35% normal stroma Normal: 100% kidney Research Specimen Specimen Process Time Blood draw time: Plasma frozen time: Serum frozen time Buffy coat frozen time Cold ischemia start time: Formalin fixation start time:.
+
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+Total cold ischemia time: Formalin fixation stopped time: Total formalin fixation time Specimen Weight Normal-cortex 1-290 mg Tumor 1-200 mg Specimen Size Plasma x 3 Serum x 2 Buffy coat x 1 Cryovials x 2  Normal x 1 Tumor x 1 FFPE x 2  Normal x 1 Tumor x 1 Studv Patient Consent Yes wi0/24/(3re QLALI
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diff --git a/output/text/c3333373-0184-40c0-b50f-6c696a7a0faf.txt b/output/text/c3333373-0184-40c0-b50f-6c696a7a0faf.txt
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index 0000000000000000000000000000000000000000..5750c6e5a090e8d1ded255758cdf2c89b2e84333
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+Clinical Diagnosis & History: Palpable'left breast cancer showing IDc on core. UUID:D5EF8C37-811E-4287-84E5-E6ED71217971 'Redacted Specimens Submitted: TCGA-AO-A03T-01A-PR 1: sp: Sentinel node #1, level one, left axilla (fs). 2: SP: S Sentinel node #2, level one, left axilla (fs) SP: S Sentinel node #3, level one, left axilla (fs). 4: SP: I Left breast 5: Sp: Level one anu . lymph nodes left axilla DIAGNOSIS: 1) LYMPH NODE, SENTINEL #1, LEFT AXILLA LEVEL I, BIOPSY:S - METASTATIC CARCINOMA INVOLVING ONE OUT OF ONE LYMPH NODE (1/1).) - NO EXTRANODAL EXTENSION SEEN. 2) LYMPH NODE. SENTINEL #2, LEFT AXILLA LEVEL I, BIOPSY:S - ONE BENIGN LYMPH NODE (O/1). 3) LYMPH NODE, SENTINEL #3, LEFT AXILLA LEVEL I, BIOPSY:S - METASTATIC CARCINOMA INVOLVING ONE OUT OF ONE LYMPH NODE (1/1). - NO EXTRANODAL EXTENSION SEEN. 4) BREAST, LEFT, TOTAL MASTECTOMY: - INVASIVE DUCTAL CARCINOMA, NOS TYPE, HISTOLOGIC GRADE III/III (SLIGHT OR NO TUBULE FORMATION).  NUCLEAR GRADE II/III (MODERATE VARIATION IN) SIZE AND SHAPE), MEASURING 2.5 CM, GROSSLY. - DUCTAL CARCINOMA IN SITU (DCIS) IS ALSO IDENTIFIED, SOLID TYPE WITH INTERMEDIATE NUCLEAR GRADE AND MODERATE NECROSIS. - LOBULAR INVOLVEMENT BY DCIS IS PRESENT.S - THE DCIS CONSTITUTES <= 25% OF THE TOTAL TUMOR MASS, AND IS PRESENT ADMIXED WITH AND AWAY  FROM THE INVASIVE COMPONENT. - THE INVASIVE CARCINOMA IS LOCATED NI THE UPPER OUTER QUADRANT AND CENTRAL AREA. - THE DCIS IS LOCATED IN THE UPPER OUTER QUADRANT AND CENTRAL AREA.S - NO INVOLVEMENT OF THE NIPPLE BY EITHER IN SITU OR INVASIVE CARCINOMA IS IDENTIFIED. - VASCULAR INVASION IS PRESENT. - NO INVOLVEMENT OF THE SURGICAL MARGINS BY BITHER INVASIVE OR IN SITU CARCINOMA IS IDENTIFIED. ** Continued on next page ** 1cs-0-3 1 carckoma, lifi1fraHty duct, Nos 85ov13 Site: breest, Nos Cs0.J 10/21f
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+- NO SKIN INVOLVEMENT BY CARCINOMA IS IDENTIFIED. - THE NON-NEOPLASTIC BREAST TISSUE SHOWS BIOPSY SITE CHANGES, STROMAL FIBROSIS, ADENOSIS AND FIBROCYSTIC CHANGES. - RESULTS OF SPECIAL STAINS (ARE AS FOLLOWS: Immunohistochemical stains were performed on formalin-fixed tissue with the following results for invasive carcinoma (block 4 T 11): ESTROGEN RECEPTOR (6F11, 95% nuclear staining with moderate intensity PROGESTERONE RECEPTOR (1E2; 60% nuclear staining with moderate intensity HER2 (HercepTest; - Negative (0 ) Controls are satisfactory. Comment: HercepTestTM ) is an FDA-approved method for assessment of HER2 protein overexpression in breast cancer tissue routinely processed for histological evaluation. The HER2 test results are reported in accordance with the Asco/cAP guideline recommendations for HER2 testing in breast cancer (J Clin Oncol 2007; 25(1):1-28). 5) LYMPH NODES, LEFT AXILLA LEVELS I AND II, RESECTION: - NINE BENIGN LYMPH NODES (0/9). I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. *** Report Electronically Signea out'  Special studies: Result Special Stain. Comment NEG-HER2 Gross Description: 1).The specimen is received fresh for frozen section consultation, labeled "sentinel node number one level 1 left axilla" and consists of a pink-tan lymph node measuring 1.2 x 1.0 x 0.4 cm.  Bisected and entirely submitted for frozen section. Summary of sections: FSC -- frozen section control ** Continued on next page
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+Page 3 of 5 2).The srecimen is received fresh for frozen section consultation, labeled "sentinel node number two level 1 left axilla" and consists of tan lymph. node measuring 1.0 x 0.5 x 0.5 cm. Bisected and entirely submitted for frozen section. Summary of sections: FSC -- frozen section control 3).The specimen is received fresh for frozen section consultation, labeled "sentinel node number three level 1 left axilla" and consists of a tan lymph node measuring 1.5 x 0.8 x 0.8 cm. Bisected and entirely submitted for frozen section. Summary of sections: FSC -- frozen section control. 4). The specimen is received fresh, labeled "left breast stitch marks. axillary tail" and consists of a breast measuring 21.5 x 17.5 x 4 cm with overlying skin ellipse measuring 9.5 x 3 cm.  Situated centrally on the skin. measuring 3.4 x 2.5 cm.. A suture demarcates the axillary aspect. The posterior surface of the breast is inked black and the specimen is serially sectioned to reveal a centrally located white-tan firm tumor measuring 2.5 x 2.5 x 2 cm with extension into upper outer quadrant, and located 1.1 cm from the deep margin. A metal clip marking the previous biopsy site is identified.  Sectioning of the axillary aspect reveals no grossly. identifiable lymph nodes. Representative sections are submitted. TPS is taken. Summary of sections: N - nipple NB - nipple base D  deep margin BX - biopsy site with tumor. UIQ - upper inner quadrant LIQ lower inner quadrant UOQ  upper outer quadrant LOQ  lower outer quadrant 5). The specimen is received fresh, labeled "level 1 and 2 lymph nodes left axilla". It consists of a 8 x 8 x 1.5 cm fragment of fibroadipose tissue without orientation.  Multiple lymph nodes are identified, ranging in size from 0.3 cm to 1.2 cm. All identified lymph nodes are submitted. Summary of sections: LN - whole lymph nodes Continued on next page.
+
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+Summary of Sections: Part 1:  SP: Sentinel node #1, level one, left axilla (fs). Block Sect. Site PCs 1 Fsc 1 Part 2: SP: Sentinel node #2, level one, left axilla (fs). Block Sect. Site PCs 1 FSC 1 Part 3: SP: Sentinel node #3, level one, left axilla (fs). Block Sect. Site PCs 1 FSC 1 Part 4: SP: Left breast Block Sect. Site PCs BX 5 1 D 2 2 LIQ LOQ 2 N 17 NB T 20  TEST 20 UIQ 2 2 UOQ 2 Part 5:  SP: Level one and two lymph nodes left axilla. Block Sect. Site pCs LN 9 Intraoperative Consultation: examined at the time of the intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS: METASTATIC DUCT CARCINOMA. PERMANENT DIAGNOSIS: SAME 2) FROZEN SECTION DIAGNOSIS: BENIGN. PERMANENT DIAGNOSIS: SAME 3) FROZEN SECTION DIAGNOSIS: METASTATIC DUCT CARCINOMA. PERMANENT DIAGNOSIS: SAME ** Continued on next page *
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+* End of Report
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+UUID: E74526B4-ED84-473B-8607-AB0085319495 TCGA-SX-A71V-01A-PR Redacted Ecd-O-3 Result Typet Surgicai Pathology Report Result Date: Performed By: '8Q6013 Encounter Info: Sat Q Bidrey NOS Surglcal Pathology Report CeH  hU 8/8/i3 Surgical Pathology Report Requested By: DIAGHOSIS: Procedure/laterality: Right kidney, partial nephrectomy. Histologic type: Renal cell carcinoma, papillary type, mixture of Type l and Tpe 2. Nuciear grade (Fuhrman, 1-4) : 2 of 4. Tumor size: 1.5 cm in greatest dimension. Tumor site: Upper pole. Tumor focality: Unifocal Sarcomatoid features: Absent. Tumor necrosis: Absent. Microscopic tumor extension: Confined to the renal parenchyma with a dense fibrous capsule. Surgical margins: Negative Lymph-vascular invasion: Absent. Lymph nodes: Not applicable. Pathologic findings  in nonneoplastic kidnsy: Mininal nephrosclerosis. Pathologic staging: pIl, NX, MX. Positive for viable papillary renal~ cell carcinoms. Block(s) containing malignancy suitable for additional testing: and A3 Reri CLINICAL INFORMATION: Right zenal nass. SPECIMEN(S) : A:Right renal ma9s GROSS DESCRIPTION: Performed by A.  Received fresh labeled and "right renal Surface is". smooth membranous surface designated Carota's fascia. This is inked black. On the other surface there is some grossly identifiable renal parenchyma, 2.2  1.5 x 0.3 cm. The renal parenchymsl margin is inkad blue. Within the renal parenchyms approximately 0.3 from the inked margin, is . CM. Fresh tumor is submitted for reszarch Danresentative sactions are submitted in cassettes labeled llows: Al-A4) Sections of renal mass and margins; A5  of tissue corresponding to research Support for the diagnosis in this case may have included the use of inmnunohistochemistry tasts that were devri--.  aristics were determined by They have not been cleared 3r approved by the u.5. soou au. .rug Administration (FDA). The FnA has determined that such clearance or approval is not necessary. Thes. tests should not be regarded  investigational or for research. This laboratory is certified under the Clinical to perforn high complexity clinical laboratory testing.
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diff --git a/output/text/c4186ddd-256b-4ac9-9b71-bb248bc4858c.txt b/output/text/c4186ddd-256b-4ac9-9b71-bb248bc4858c.txt
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index 0000000000000000000000000000000000000000..8ad5664359a5e22a3b52dc90dc2f0cf3e0a21896
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+FINAL DIAGNOSIS: .Etght Breast, moDified radical mastectomy - A.  MULtiFOCAl InFILTrATing.QuctaL CARCInQMA, NOTTInghAm GrADe 2 (nUCLEAR GRADe 3, TUBULE ScOre 3, mItotic activIty ScOre 1; total scORe 7i9). B. LArgESt TUmOr mEASUReS 1.5 Cm, LOcATeD In THe UppER/OUTER qUADRAnt, CORRELATed WITh THe BIOpSied 10 O'CLOCK LESiOn. C. SECOND TUMOR MEASURES 1.2 CM IN GREATEST DImENSION, LOCATED AT THE JUNCTION OF THE UPPER/OUTER AND UPPER/INNER QUADRANTS AND CORRELATES WITH THE BIOPSIED 12 O'CLOCK LESION.E D.  BOTH TUMORS ARE MORPHOLOGICALLY SIMILAR. E. EXTENSIVE LYMPHOVASCULAR INVASION IS PRESENT.  MARGINS ARE NEGATIVE; INVASIVE TUMOR APPROACHES MOST CLOSELY TO THE MARGIN POSTERIOR TO THE 12 O'CLOCK LESION (see comment). DUCTAL CARCInOmA IN-SITU (DCiS), nUCLEAR GRADE 2, CRIbRIfORm TYpE, COMpRiSiNg APpROXImATeLy 5% OF TUMOR MASS (DCIS IS ASSOCIATED WITH BOTH TUMORS). H. BIOPSY SITE CHANGES (see comment). SIX AXILLARY LYMPH NODES WITH METASTATIC CARCINOMA (6/16). !. J. LARGEST METASTASIS MEASURES 1.1 CM. K. EXTRACAPSULAR EXTENSION IS PRESENT, AND MEASURES APPROXIMATELY 0.3 CM.  UNINVOLVED BREAST WITH FIBROCYSTIC CHANGES AND FIBROADENOMA. M.  NiPPLE AND SKIN ARE NEGATIVE FOR NEOPLASM. N.  SKELETAL MUSCLE, NEGATIVE FOR TUMOR. 1cs-0-3 O. CALCIFIC ATHEROSCLEROSIS. CASE SYNOPSIS: Carcioma, nifniltnHng ouctel, nos 85o0/3 SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREASTE Sitr: brt, Nos c5o.9 313/m LATERALITY: Right PrOceDure:  Modified radical mastectomy LOCAtION: Upper outer quadrant Upper inner quadrant SIZE OF TUMOR: Maximum dimension invasive component: 1.5 cm  MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: Yes TUmOR AgGREGATE SIZE: Sum of the sizes of multiple invasive tumors: 2.7 cm TUMOR TYPE (invasive component): Ductal adenocarcinoma, NOS NOTTINGHAM SCORE: Nuclear grade: 3 Tubule formation: 3 Mitotic activity score: 1 UUID:CC7D1177-1638-4A80-A3AA-266ADC260EC9 TcgA-Bh-A0h7-01A-pR Redacted Total Nottingham score: 7 Nottingham grade (1, 2, 3): 2 ANGIOLYMPHATIC INVASION: Yes DERMAL LYMPHATIC INVASION: No CALCIFICATION: No Tumor type, In situ: Cribriform Percent of tumor occupied by in situ component: 5 % SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:E No Distance of invasive tumor to closest margin: 7 mm SURG MARGINS INVOLVED BY IN SITU COMPONENT: No Lymph nODeS POsITive: 6 LYMPH NODES EXAMINED: 16 METHOD(S) OF LYMPH NODE EXAMINATION: H/E stain SIZE OF NODAL METASTASES: Diameter of largest lymph node metastasis: 11 mm LYMPH NODE METASTASIS(-ES) WITH EXTRACAPSULAR EXTENSION: Yes  NON-NEOPLASTIC BREAST TISSUE: Fibroadenoma, FCD t Stage, PathOlOgIC: pT1c N Stage, PathologIc: pN2a m Stage, pathologic: pMX ESTROGEN RECEPTORS: positive PROGESTERONE RECEPTORS: positive HER2/NEU: zero or 1+ eis circh DiSQUAI
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diff --git a/output/text/c4502346-bd69-4191-9e4e-c631603b5479.txt b/output/text/c4502346-bd69-4191-9e4e-c631603b5479.txt
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index 0000000000000000000000000000000000000000..d8f65eff6814df4a64414fdf069936a988221cc5
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+UUID:335BFEB5-6356-43A3-896D-50BF3830859E Redacted 1 N ame: Case #: DOb: Collected: Gender: Received: Mrn: Reported: Location: Copy To: Physician: Pathologic Interpretation: A. Left breast mastectomy: - INVASIVE MAMMARY CARCiNOMA, MICROPAP!LLARY TYPE with focal ductal features, poorly differentiated,  Nottingham Grade 3 (3 + 3 + 3 = 9), 7.5 cm in greatest dimension, present in 13/14 slides, constituting 80% of tissue sampled. - The invasive tumor is focaly present less han 0.1 cm from the anterior/skin margin and less than 0.1 cm from the deep posterior margin in 5 blocks.. - Extensive lymphovasculr invasion is present in numerous foci in multiple blocks. - DUCTAL CARCINOmA IN STU, high nuclear grade (DiN 3), micropapillary type, present as a single focus (slide 7) - Skin with scar and extensive dermal lymphovascular invasion. - Skeletal muscle is present. - ER, PR and HER2 are pending, an addendum will foilow. (please see tumor summary) B. Left inTrA mammAry lymph noDe dissecTIOn: - METASTATIC CARCiNOMA is present in five (5) of five (5) lymph nodes with extranodal extension (5/5) - The largest metastatic deposit is 1.2 cm in greatest linear dimension. c. Left AxIllAry Lymph nOde DissecTiON: - METASTATIC CARCINOMA to seventeen (17) of twenty (20) lymph nodes (17/20). - The largest metastatic deposit is 2.9 cm in greatest linear dimension. D. Additional Left breast tissue: - Fibroadipose tissue, negative for carcinoma.. E. Left Lymph noDe dissecTion (Level 3): - METASTATiC CARCINOMA to two (2) of two (2) lymph nodes (2/2), largest metastatic deposit is 2.2 cm in greatest  linear dimension.. F. Lymph nODe DissEcTion ABOve Left brachial pLeXus: - METASTATIC CARCINOMA to five (5) of five (5) lymph nodes, largest metastatic deposit is 1.8 cm in greatest linear dimension. Tumor Summary /cs-0-3 Casunomt, iiVesNe micupepi`Hmy, Specimen: ifnadutal - Total breast (including nipple and skin). 8507/3 Procedure: Stei brast,Ns - Total mastectomy (including nipple and skin) 050.9 Lymph Node Sampling: - Axillary dissection (partial or complete dissection) - Lymph nodes present within the breast specimen (ie, intramammary lymph nodes) Specimen Integrity: - Single intact specimen (margins can be evaluated)
+
+--- Page 2 ---
+Specimen Laterality: - Left Tumor Site: Invasive Carcinoma - Lower outer quadrant - Upper inner quadrant - Lower inner quadrant - Central Tumor Size: Size of Largest Invasive Carcinoma - Greatest dimension of largest focus of invasion over 0.1 cm: 7.5 cm. - Additional dimensions: 6 x 2 cm Tumor Focality: - Single focus of invasive carcinoma Macroscopic and Microscopic Extent of tumor: - Skin: Invasive carcinoma directly invades into the dermis without skin ulceration. - Nipple: DCiS does not invoive the nipple epidermis - Skeletal muscle: Skeletal muscle is present and is free of carcinoma. Ducta! Carcinoma In Situ (DCIS): - DCIS is present - Extensive intraductal component (EiC) negative *Size (Extent) of DCIS Estimated size (extent) of DCiS (greatest dimension using gross and microscopic evaluation) is at least: 0.15 cm Number of blocks with DCIS: 1 Number of blocks examined: 14 Architectura! Pattern: Micropapillary Nuclear Grade: Grade III (high) Necrosis: Not identitied Lobular Carcinoma In Situ (LCis): Not identified. Histologic Type of Invasive Carcinoma: - Invasive micropapillary carcinoma with focal ductai features Histologic Grade: Nottingham Histologic Score - Glandular (Acinar) /Tubular Differentiation: Score 3: <10% of tumor area forming glandular/tubular structures. - Nuclear Pleomorphism: Score 3: Vesicular nuclei, often with prominent nucleoli, exhibiting marked variation in size and shape, occasionally with very large and bizarre forms - Mitotic Count Score 3 - Overall Grade: Grade 3: scores of 8 or 9 Margins: - Margins uninvolved by invasive carcinoma - Distance from anterior margin: <1 mm - Distance from posterior margin: <1 mmm - Margins uninvolved by DCIS Treatment Effect: Response to Presurgical (Neoadjuvant) therapy: - in the Breast: No known presurgical therapy - in the Lymph Nodes: No known presurgical therapy Lymph-Vascular Invasion: PRESENT Dermal Lymph-Vascular Invasion: PRESENT Lymph Nodes: - Number of sentinel iymph nodes examined: 0 - Total number of lymph nodes examined (sentinel and Nonsentinel): 32 - Number of lymph nodes with macrometastases (>0.2 cm): 29 - Size of largest metastatic deposit: 2.9 cm *Extranodal Extension: Present *Method of Evaluation of Sentinel Lymph Nodes: Hematoxylin and eosin (H&E), one level. Patho!ogic Staging (pTNM): pT3, pN3a, pM n/a Primary Tumor: pT3: Tumor >50 mm in greatest dimension Regional Lymph Nodes: pN3a: Metastases in 10 or more axillary lymph nodes (at least 1 tumor deposit greater than 2.0 mm) Distant Metastasis: Not applicable Ancillary Studies: Estrogen Receptor: PENDING Progesterone Receptor: PENDING Her2/NEU: PENDING Microcalcifications: Not identified Page 2 of 4
+
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+NOTB: Same mmunohstochemical arzibodies are analyte specific reagents (ASRs) validated by aur iabontory. These ASRs are clmcaly usefis indicators that do nct requsre FDA approval. These clones are used. 1D5=5R, PgR 636-PR, A485=HER2. H-11=EGFR. All mmnohustcchemical staws are used wth fomalin or molecuar fixed, paraffin embedded tssue. Detectson is by Bnvision Method. The ressts are read by a pathologist as panive or negative. As the attending pathologist, I attest that I: (i) Examined the relevant preparation(s) for the specimen(s); and (ii) Rendered the diagnosis(es). ***Electronically Signed Out By*** Procedures/Addenda Addendum Date Ordered: Status: Signed Out Date Complete: Date Reported: Addendum Diagnosis The tumor cells are positive for ER and PR, negative for HER2 (0).. Clinical History:. Status post previous lumpectomy Operation Performed Left breast completion, mastectomy with axillary node dissection. Pre Operative Dlagnosis: Left breast cancer. Specimen(s) Received: A: Left breast (short superior and long lateral). B: Intra mammmary lymph node C: Left axillary lymph nodes D: Additional left breast tissue E: Level 3 lymph nodes F: Lymph nodes above brachial plexus Gross Description: A. Received in formalin is a modified left radical mastectomy specimen that weighs 190 grams and measures 16.0 x 11.0 x. 1.0 cm. There is a tan ellipse of skin that measures 6.3 x 5.8 cm, an areola measuring 4.2 x 4.0 cm and a nipple that. measures 1.0 cm. There is a white lesion on the 11 o'clock aspect of the areola that measures 0.5 cm in greatest. dimension. Along the 12 o'clock to 6 o'clock aspect of the nipple, it appears to be slightly retracted. Grossly, no other lesions or masses are identified. The specimen has previously being inked black and sectioned to allow for fixing. On cut section, there is a 7.5 x 6.0 x 2.0 cm ill-defined, indurated, tan/yellow lesion that is retro-areolar in location. This lesion comes within 0.2 mm of the deep margin, 0.6 cm from the inferior margin, 4.5 cm from the superior margin, 3.5 cm from the inferior margin, 4.5 cm from the lateral margin and 2.5 cm from the medial margin. The remainder of the breast parenchyma is composed predominantly of homogeneous yellow adipose tissue with a 20% stroma to 80% adipose tissue ratio. Grossly, no lymph nodes are identified. A small section of the specimen was taken for research. Sections. submitted as follows: Page 3 of 4
+
+--- Page 4 ---
+1-10  Section of mass in relation to deep inked margin, nipple and skin 11 Upper inner quadrant 12 Lower inner quadrant 13 Upper outer quadrant 14 Lower outer quadrant. B. Received in formalin is a piece of fibroadipose connective tissue that measures 4.6 x 3.8 x 1.3 cm. Grossly, five lymph. nodes are identified. The largest measures 1.4 cm in greatest diameter. Sections as follows: 1 Largest lymph node, trisected 2 One lymph node, trisected. 3 One lymph node, bisected. 4 Up to three lymph nodes. 5-7 Possible lymph nodes C.  Received in formalin is a segment of fibroconnective adipose tissue with grossly identifiable enlarged lymph nodes that measures 12.0 x 5.8 x 2.5 cm. Grossly, nineteen lymph nodes are identified. The largest measuring 3.7 x 2.7 x 1.6 cm.. Sections submitted as follows: 1 Five lymph nodes, submitted in toto Representative sections of largest lymph node Representative sections of two lymph nodes 4 Representative section of one lymph node 5 Representative section of one lymph node 6 Representative sections of two lymph nodes Representative sections of two lymph nodes 8 Representative sections of three lymph nodes 9 Representative section of one lymph node 10 Possible lymph nodes D. Received in forrmalin is a piece of fibroconnective adipose tissue that measures 5.0 x 2.5 x 0.5 cm. Submitted in toto in two cassettes. E. Received in formalin are two pieces of fibroconnective adipose tissue, one measuring 1.1 x 0.6 x 0.5 cm and the other measuring 3.0 x 1.2 x 0.5 cm. Sections submitted as follows: 1 Smaller specimen bisected and submitted in toto 2 Larger piece bisected and submitted in toto F.  Received in formalin are several fragments of fibroconnective adipose tissue that measure in aggregate 5.0 x 1.0 x 0.5 cm. Grossly, five lymph nodes are identified, ranging in size from 1.0 to 1.5 cm in greatest dimension. Sections submitted as follows: Largest lymph node bisected and submitted in toto 2 One lymph node, bisected 3 Three lymph nodes submitted in toto  Page 4 of 4
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+COrY DIAGNOSIS: 1. Kidney, left (left radical nephrectomy): Renal cell carcinoma, chromophobe-type, with areas of high-grade sarcomatoid differentiation. Tumor approaches but does not go through the capsule. Vascular and ureteral margins are free of tumor. Adrenal gland, no tumor seen. 2. Lymph nodes, retroperitoneal (excision): Reactive lymph nodes with marked sinus histiocytosis, no tumor seen. CLINICAL INFORMATION: HISTORY:LEFT RENAL MASS PROCEDURE: PREOP DX:#LEFT RENAL MASS POSTOP DX: LEFT RENAL MASS OPERATIVE FINDINGS: VERY LARGE LEFT RENAL MASS AND ENLARGED HILAR LYMPH NODES SPECIMENS SUBMITTED: 1) KIDNEY, LEFT NEPHRECTOMY 2) RETRO PERITONEAL LYMPH NODE GROss DEscRIPTION: Received in two formalin containers labeled with the patient's name and medica! record number, and as:. 1. "Left kidney" is a large soft tissue specimen weighing 3,800 grams measuring 22 x 18 x 15 cm. The ureter. is marked with yellow ink and the vessel is marked with blue ink. The adrenal gland is,identified. Once cut, there is a large, extensively red mass lesion without gross evidence of fibrosis, scarring,'or encapsulation. This. mass lesion occupies a major portion of the specimen. There is a small rim of normal appearing renal tissue with a maximum dimension of 8 cm. For procurement, samples of both normal renal tissue and the mass. lesion are sent to  The specimen is placed in formalin but other portions are submitted in ethanol as a touch prep and also as electron microscopy. The special instructions are confirmatory for culture, frozen, and touch prep.. Patient Identification Page 1
+
+--- Page 2 ---
+Code of section for #1: A - vascular edges. B-I - representative portions of tumor J - normal-appearing renal parenchyma K-S - tumor T-U - adrenal gland V-JJ - representative portions of tumor KK - tumor fixed in 70% ethanol. LL-PP - tumor and/or kidney at capsule 2. "Retroperitoneal lymph nodes" is a tan soft tissue mass measuring 7.5 x 3:5 x 1.5 cm. Upon palpation, five nodes are appreciated, the largest measuring 2.5 x 1 x 1 cm and the smallest measuring 1 x 1 x 0.7 cm. The lymph nodes are serially sectioned. Code of section for specimen 2:. A-B - representative section of largest lymph node. C-F - representative portions of the remaining lyrnph nodes. Reviewed By: SURgICAL PATH CASE CONF, Patient Identification. Page 2
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index 0000000000000000000000000000000000000000..43424ee8616bb2eb0b658ac04630fad3e0d088f6
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+140-0-3 TSS Pat ID: Carcm oma, Infhnutng cluct, nos 850v|3 SPECIMENS: A. SENTINEL LYMPH NODE #1 B. SENTINEL LYMPH NODE 2 RIGHT AXILLA CqcF Sip7 busst,nos C5o.9 c50.4 15/9f10 C. SENTINEL LYMPH NODE 3 RIGHT AXILLA D. SENTINEL LYMPH NODE 4 RIGHT AXILLA E. SENTINEL LYMPH NODE #5 F. RIGHT BREAST UUID:089E0F89-6845-4E3E-843E-EC98D39863F60 G. ADDITIONAL LATERAL TISSUE RIGHT BREAST TCGA-E2-A109-01A-pR Redacted H. ADDITIONAL SUPERIOR RIGHT BREAST TISSUE SPECIMEN(S): A. SENTINEL LYMPH NODE #1 B. SENTINEL LYMPH NODE 2 RIGHT AXILLA C. SENTINEL LYMPH NODE 3 RIGHT AXILLA D. SENTINEL LYMPH NODE 4 RIGHT AXILLA E. SENTINEL LYMPH NODE #5 F. RIGHT BREAST G. ADDITIONAL LATERAL TISSUE RIGHT BREAST H. ADDITIONAL SUPERIOR RIGHT BREAST TISSUE INTRAOPERATIVE CONSULTATION DIAGNOSIS: TPA, B, C, D, E. Sentinel lymph nodes #1, 2, 3, 4, 5, biopsies: No tumor seen.. By Dr, called to Dr. at. .(A,B), C, D) and at .(E). GROSS DESCRIpTIOn: A. SENTINEL LYMPH NODE #1 Received is a tan-pink fatty lymph node (1.8 x 0.9 x 0.3 cm). The specimen is serially sectioned, touch prep was performed. The specimen is submitted is cassettes A1-A3.. B. SENTINEL LYMPH NODE #2 RIGHT AXILLA Received is a tan-pink fatty lymph node (1.5 x .6 x .3 cm). The specimen is serially sectioned and touch preps are taken. The specimen is submitted in toto in B. C. SENTINEL LYMPH NODE #3 RIGHT AXILLA Received are two tan-pink lymph nodes (1.0 x 0.3 x 0.2 cm and 1.4 x .6 x .5 cm). The specimen is serially sectioned and touch preps are taken. The specimen is submitted as follows:. C1:  one lymph node, trisected C2:  one lymph node serially sectioned D. SENTINEL LYMPH NODE #4 RIGHT AXILLA Received is a tan-pink lymph node (1.0 x .6 x .3 cm). The specimen is serially sectioned and touch preps are taken. The specimen is submitted in toto in cassette D.. E. SENTINEL LYMPH NODE #5 Received is a tan-pink lymph node (.9 x .7 x .2 cm). The specimen is serially sectioned and touch preps are taken. The specimen is submitted in toto in cassette E. F. RIGHDBREAST Received fresh labeled with the patient name, designated "right breast", is a simple mastectomy specimen weighing 1181 grams and measuring overall 28 x 23 x 4.5 cm. The specimen is received with orientation, a suture indicating the axillary aspect. The overlying beige-tan ellipse of skin measures 21 x 11 cm. The surface demonstrates three areas of brown hyperpigmentation, the largest measuring 1 x 0.6 cm to the smallest measuring 0.5 x 0.3 cm. A light tan raised lesion is noted at 3 o'clock on the. skin measuring 0.5 x 0.5 cm. The light tan areola measures 2.3 cm in diameter, the everted nipple. measures 1 cm in diameter. The deep margin is inked black. The specimen is serially sectioned from. axilla to medial aspect and shows a firm beige-tan lesion in the upper outer quadrant at approximately 10 o'clock approaching the deep surgical margin at a distance of 4.3 cm. The lesion measures 2.2 x 1.9 x 1.5 cm. An ill defined white firm fibrous area is aiso demonstrated at approximately 12 o'clock measuring 1.5 x 1.2 x 1 cm. This area is located 5.5 cm from the lesion. An ill defined irregular dense. white area is shown in the lower inner quadrant measuring 2.5 x 2 x 2 cm. This area is located approximately 10.5 cm from the lesion. The remainder of the breast parenchyma shows dark yellow adipose tissue. A portion of the specimen was submitted for tissue procurement. Representative sections are submitted as follows: F1-F4: the lesion in the upper outer quadrant F5: deep margin overlying lesion F6-F8: sections of white firm fibrous tissue at 12 o'clock
+
+--- Page 2 ---
+F9-F16: multiple sections of ill defined firm area in lower inner quadrant F17-F18: representative sections of upper inner quadrant F19-F21: representative sections of the lower outer quadrant F22-F23: additional sections from the upper outer quadrant adjacent to lesion F24: section of nipple F25: section of skin demonstrating the raised tan lesion at 3 o'clock F26: additional section of skin F27-F28: possible lymph nodes G. ADDITIONAL LATERAL TISSUE RiGHT BREAST Received in formalin in a container labeled with the patient name, designated "additional lateral tissue", is a fragment of dark yellow adipose tissue measuring 8 x 2.2 x 0.5 cm. The exterior surface is inked black. The entire specimen is submitted in cassettes G1-G4. H. ADDITIONAL SUPERIOR RIGHT BREAST TISSUE  Received in formalin in a container labeled with the patient name designated "additional superior right breast tissue", is a fragment of yellow adipose tissue measuring 3 x 2.2 x 1 cm. The entire specimen is submitted in cassettes H1 and H2. DIAGNOSIS: A. SENTINEL LYMPH NODE #1, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR TUMOR (0/1). B. SENTINEL LYMPH NODE #2, RIGHT AXILLA, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR TUMOR (0/1). C. SENTINEL LYMPH NODE #3, RIGHT AXILLA, EXCISION: - TWO LYMPH NODES, NEGATIVE FOR TUMOR (0/2). D. SENTINEL LYMPH NODE #4, RIGHT AXILLA, EXCISION:  ONE LYMPH NODE, NEGATIVE FOR TUMOR (0/1). E. SENTINEL LYMPH NODE #5, EXCISION: -ONE LYMPH NODE, NEGATIVE FOR TUMOR (0/1). F? RIGHT BREAST, SIMPLE MASTECTOMY: - TWO FOCI OF INVASIVE DUCTAL CARCINOMA, TUMOR SIZE 2.2 x 1.9 x 1.5 CM. AND 1 x 1 CM. RESPECT!VELY,  SBR GRADE III IN LARGE TUMOR FOCUS - DUCTAL CARCINOMA IN-SITU, COMEDO AND SOLID TYPES, HIGH  NUCLEAR GRADE WITH MICROCALCIFICATIONS. - MARKED FIBROCYSTIC DISEASE AND ADENOSIS WITH EXTENSIVE MICROCALCIFICATIONS. - SURGICAL RESECTION MARGINS, NEGATIVE FOR TUMOR. - FOCAL SEBORRHEIC KERATOSIS OF SKIN. - SEE TEMPLATE. Note: There are two foci of invasive ductal carcinoma identified: the large one is present in the upper outer quadrant measuring.2.2 cm. This focus is SBR grade ill. Another small tumor focus is present in  the central area at the 12 o'clock position measuring 1 x 1 cm. This focus of tumor is SBR grade I, with tubular formation. Ductal carcinoma in-situ containing microcalcifications is associated with the large focus of invasive carcinoma. In addition microcalcifications are also present in mutifoci of adenosis and fibrocystic disease. G. ADDITIONAL LATERAL TISSUE RIGHT BREAST, EXCISION: - BENIGN ADIPOSE TISSUE, NEGATIVE FOR TUMOR. H. ADDITIONAL SUPERIOR RIGHT BREAST TISSUE, EXCISION:  - BENIGN ADIPOSE TISSUE, NEGATIVE FOR TUMOR. SYNOPTIC REPORT - BREAST Specimens Involved Specimens: F: RIGHT BREAST Specimen Type: Mastectomy Needle Localization: No Laterality: Right Invasive tumor: Present Multifocality: Yes WHO CLASSIFICATION Invasive ductal carcinoma, NOs 8500/3 Specimen size: Size of Invasive focus 2.2cm.
+
+--- Page 3 ---
+Additional dimensions: 1.9cm x 1.5cm Tumor Site: Upper outer quadrant. Central Margins: Negative Distance from closest margin:  4.3cm Tubular score: 3(<10% tubule) Nuclear grade: 3 Mitotic score (Olympus 40x): 2 (7-13/10 Modified Scarff Bloom Richardson Grade: III (8-9 points) Necrosis: Absent Vascular/Lymphatic Invasion: None identified Lobular neoplasia: None Lymph nodes: Sentinel ymph node only Lymph node status:. Negative 0/6 DCIS present Margins uninvolved by DCIS. DCIS Quantity: Estimate % 15 DCIS type: Comedo Solid DCIS location: Associated with invasive tumor Nuclear grade: High Necrosis:  Present Location of CA++: DCIS Benign epithelium Pathological staging (pTN): pT 2 N 0 SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimens Involved Specimens: F: RIGHT BREAST SPECIMEN: Other simple mastectomy Block Number: F1 ER: Positive - Allred Score:  8 = Proportion score: 5 + Intensity Score 3 PR: Negative - Allred Score: 0 = Proportion Score 0 + Intensity Score 0. COMMENT: The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring range from 0 to 8. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Alred score of less than or equal to 2. Methodology: Fixation Type and Length: Tissue was fixed in 10% neutral buffered formalin ( for no less than 8 and no longer than 24 hours. Antibody and Assay Metnodology:. Mouse anti-human ER and PR, ( ). Comment: This assay can be used to select invasive breast cancer patients for hormone therapy (1). ER and PR analysis was performed on this case by immunohistochemistry utilizing the ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) antibody provided by following the manufacturer's instructions listed in the package insert. This assay was not modified, and adherence to all instruction and guidelines were strictly followed. Interpretation of the ER/PR immunohistochemical staining characteristics is guided by published results in the medical literature (1), information provided by the reagent manufacturer and by internal review of staining performance within the. 1. narvey JM, et al. Estrogen receptor status by immunohistochemistry is superior to the ligand-binding assay for predicting response to adjuvant endocrine therapy in breast cancer. J Clin Oncol. 17:1474- 1481, 1999 CLINICAL HISTORY: Patient is a  year old white female who underwent an ultrasound guided core biopsy on. which revealed invasive ductal carcinoma of right breast with extensive pleomorphic malignant appearing microcalcifications on mammogram. The patient opted for a right simple mastectomy and sentinel Iymph node biopsy after consideration. PRE-OPERATIVE DIAGNOSIS: Right breast cancer..
+
+--- Page 4 ---
+ADDENDUM: SYNOPTIC REPORT - BREAST HER-2 RESULTS Specimens Involved Specimens: F: RIGHT BREAST HER2 Status Results, Immunohistochemistry Evaluation. SPECIMEN Surgical Excision Block Number: Block F1 Interpretation: Equivocal Intensity: 2+ % Tumor Staining: 50% FISH Ordered YES DATE METHODOLOGY Methodoloav: Fixation Type and Length: Tissue was fixed in 10% neutral buffered formalin ( ) for no less than 8 and no longer than 24 hours. Antibody and Assay Methodology:. Rabbit anti-human HER2, HerceptestTM (FDA-approved test kit),. Control Slides Examined: External kit-slides provided by manufacturer (cell lines with high, low and negative HER2 protein expression), and in-house known HER2 amplified control tissue were evaluated along with the test tissue. These control slides run along side of this patient's sample showed appropriate staining. Adequacy of Specimen: Adequate, well preserved, clear-cut invasive carcinoma identified for HER2 evaluation.. Scoring Criterion and Scoring System: IHC Level of Expression(Score) /Tumor Cell Membrane Staining Pattern. Negative (0)/Absence of Staining Negative (1+)/Faint Incomplete membrane Staining, >10% of Cells Equivocal (2+)/Weak complete membrane Staining, >10% of Cells Positive (3+)/Strong complete membrane Staining, >10% of Cells. Equivocal Category for HER2 IHC results: A HER2, 2+ staining result that is interpreted as equivocal may not indicate gene amplification. A FISH test for HER2 gene amplification will be ordered for all HER2 IHC 2+ results. COMMENT This assay can be used to select invasive breast cancer patients for Trastuzumab (Hereptin) therapy (1,2). Clinical Trials have shown that Trastuzumab substantially increases the likelihood for an objective response and overall survival for patients with metastatic HER2-positive breast cancer, regardiess of whether HER2 tumor status was determined as IHC 3+ or FISH positive. Trastuzumab added to adjuvant chemotherapy substantially increase disease-free survival and decreases the risk of disease recurrence by about 50% for patients with early-stage HER2 protein over-expressed or gene amplified invasive breast cancer (3). HER2 analysis was performed on this case by immunohistochemistry utilizing the FDA approvec' (TM) test kit following the manufacturer's instructions listed in the package insert. This assay was not modified, and adherence to all instruction and guidelines were strictly followed. Interpretation of the HER2 immunohistochemical staining characteristics is guided by published results in the medical literature (4), information provided by the reagent manufacturer and by internal review of staining performance within the Institute Pathology Department. HER2 TEST VALIDATION This HER2 immunohistochemical assay has been validated according to the recently revised recommendations and guidelines from the NCCN HER2 testing in Breast Cancer Task Force, and the jointly issued recommendations and guidelines from ASCO and the CAP (5). 80 randomly selected breast cancer samples were tested for HER2 by IHC as outline above and interpreted as, negative (score 0/1+) equivocal (score 2+) and positive (score 3+) without knowledge of the previous reported results. These cases were also blindly read using two different FiSH assay as amplified or non-amplified and the HER2/CEP17 ratios were recorded. After analyzing these results, there was 100% concordance between the IHC and FISH results for cases that were interpreted as either positive or negative by IHC. 9 of the 80 cases were interpreted as equivocal by IHC and of these 3/9 (33%) were non-amplified by FiSH and 6/9 (66%) were found to be amplified.  Pathology Department Immunohistochemistry laboratory takes fuil responsibility for this tests performance and has programs in place to regularly monitor the proficiency and the interpretation of HER2 assays. The laboratory also participates in external quality assurance HER2 programs including the CAP proficiency testing program. REFERENCE 1. Carison RW, Anderson BO, Burstein HJ, et al., NCCN breast cancer clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2005;3:238-289. 2. Carlson RW, Brown E, Burstein HJ, et al., NCCN Task Force Report: adjuvant therapy for breast cancer. J Natl Compr Canc Netw. 2006;4:S1-S26. 3. Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Eng J Med 2005;353(16):1673-84
+
+--- Page 5 ---
+4. Leong ASy, Formby M, Haffajee Z, et al. Refinement of immunohistologic parameters for Her2/neu scoring validation by FISH and CISH. Appl Immunohistochem Mol Morphol. 2006;14:384-389. 5. Wolff AC, Hammond EH, Schwartz JN, et al., American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Human Epidermal Growth Factor Recepto 2 Testing in Breast Cancer. Arch of Path and Lab Med 2007; 131:18-43. The followings are ER and PR results of the second tumor focus measuring 1 cm. at the central area of breast tissue. SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimens Involved Specimens: F: RIGHT BREAST SPECIMEN: Surgical Excision Block Number: F7 ER: Positive - Allred Score: 8 = Proportion score: 5 + Intensity Score 3 PR: Positive - Allred Score: 7 = Proportion Score 4 + Intensity Score 3 COMMENT: The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring range from 0 to 8. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2.  Methodoloav: Fixation Type and Length: Tissue was fixed in 10% neutral buffered formalin (. ) for no less than 8 and no longer than 24 hours. Antibody and Assay Methodology: Mouse anti-human ER and PR, (Dako, Carpenteria, CA). Comment: This assay can be used to select invasive breast cancer patients for hormone therapy (1). ER and PR analysis was performed on this case by immunohistochemistry utilizing the ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) antibody provided by  following the manufacturer's instructions listed in the package insert. This assay was not modified, and adherence to all instruction and. guidelines were strictly followed. Interpretation of the ER/PR immunohistochemical staining. characteristics is guided by published results in the medical literature (1), information provided by the Department. 1. Harvey JM, et al. Estrogen receptor status by immunohistochemistry is superior to the ligand-binding assay for predicting response to adjuvant endocrine therapy in breast cancer. J Clin Oncol. 17:1474- 1481, 1999 SYNOPTIC REPORT - BREAST HER-2 RESULTS Specimens Involved Specimens: F: RIGHT BREAST HER2 Status Results, immunohistochemistry Evaluation SPECIMEN Surgical Excision Block Number: Block F7 Interpretation: Negative Intensity: 1+ % Tumor Staining: 10% FISH Ordered NO DATE METHODOLOGY Methodology: Fixation Type and Length: Tissue was fixed in 10% neutral buffered formalin (Pharmco Rabbit anti-human HER2, HerceptestTM (FDA-approved test kit), 1 Control Slides Examined: External kit-slides provided by manufacturer (cell lines with nign, suw and negative HER2 protein expression), and in-house known HER2 amplified control tissue were evaluated along with the test tissue. These control slides run along side of this patient's sample showed appropriate staining. Adequacy of Specimen: Adequate, well preserved, clear-cut invasive carcinoma identified for HER2 evaluation. Scoring Criterion and Scoring System: lHC Level of Expression(Score) /Tumor Cell Membrane Staining Pattern Negative (0)/Absence of Staining Negative (1+)/Faint Incomplete membrane Staining, >10% of Cells Equivocal (2+)/Weak complete membrane Staining, >10% of Cells Positive (3+)/Strong complete membrane Staining, >10% of Cells
+
+--- Page 6 ---
+Equivocal Category for HER2 IHC resuits: A HER2, 2+ staining result that is interpreted as equivocal may not indicate gene amplification. A FISH test for HER2 gene amplification will be ordered for all HER2 lHC 2+ results. COMMENT This assay can be used to select invasive breast cancer patients for Trastuzumab (Hereptin) therapy (1,2). Clinical Trials have shown that Trastuzumab substantially increases the likelihood for an objective response and overall survival for patients with metastatic HER2-positive breast cancer, regardiess of whether HER2 tumor status was determined as IHC 3+ or FiSH positive. Trastuzumab added to adjuvant chemotherapy substantially increase disease-free survival and decreases the risk of disease recurrence by about 50% for patients with early-stage HER2 protein over-expressed or gene amplified invasive breast cancer (3). HER2 analysis was performed on this case by immunohistochemistry utilizing the FDA approved .TM) test kit following the manufacturer's instructions listed in the package insert. This assay was not modified, and adherence to all instruction and guidelines were strictly followed. Interpretation of the HER2 immunohistochemical staining characteristics is guided by published results in the medical literature (4), information provided by the reagent manufacturer and by internal review of staining performance within the Pathology Department. HER2 TEST VALIDATION This HER2 immunohistochemical assay has been validated according to the recently revised recommendations and guidelines from the NCCN HER2 testing in Breast Cancer Task Force, and the jointly issued recommendations and guidelines from ASCO and the CAP (5). 80 randomly selected breast cancer samples were tested for HER2 by IHC as outline above and interpreted as, negative (score 0/1+) equivocal (score 2+) and positive (score 3+) without knowledge of the previous reported results. These cases were also blindly read using two different FiSH assay as amplified or non-amplified and the HER2/CEP17 ratios were recorded. After analyzing these results, there was 100% concordance between the IHC and FiSH results for cases that were interpreted as either positive or negative by IHC. 9 of the 80 cases were interpreted as equivocal by IHC and of these 3/9 (33%) were non-amplified by FISH and 6/9 (66%) were found to be amplified. Institute Pathology Department Immunohistochemistry laboratory takes full responsibility for this tests performance and has programs in place to regularly monitor the proficiency and the interpretation of HER2 assays. The laboratory also participates in external quality assurance HER2 programs including the CAP proficiency testing program. REFERENCE 1. Carlson RW, Anderson BO, Burstein HJ, et al., NCCN breast cancer clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2005;3:238-289. 2. Carison RW, Brown E, Burstein HJ, et al., NCCN Task Force Report: adjuvant therapy for breast cancer. J Natl Compr Canc Netw. 2006;4:S1-S26. 3. Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Eng J Med 2005;353(16):1673-84 4. Leong ASy, Formby M, Haffajee Z, et al. Refinement of immunohistologic parameters for Her2/neu scoring validation by FiSH and CISH. Appl Immunohistochem Mol Morphol. 2006;14:384-389. 5. Wolff AC, Hammond EH, Schwartz JN, et al., American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Human Epidermal Growth Factor Recepto 2 Testing in Breast Cancer. Arch of Path and Lab Med 2007; 131:18-43. PathVysion HER-2 DNA Probe Kit Analytical Interpretation of Results: HER-2 NOT AMPLIFiED Clinical Interpretation of results Amplification of the HER-2 gene was evaluated with interphase fluorescence in-situ hybridization (FiSH) on formalin-fixed paraffin embedded tissue sections using a chromosome 17 centromeric probe and a HER-2 probe that spans the entire HER-2 gene in the Pathology Core Facility by Dr.. A majority of tumors cells displayed moderate polysomy 17 with 2 to 4 chromosome 17 signals and 2 to 4 HER-2 signals, with a HER-2/CEP 17 Ratio </=2.0, consistent with no amplification of the HER2/neu gene. Block used F1 Source of case: RPCI Tissue fixation formalin-fixed tissue Outside Case No:NA Tissue source breast Results interpreted: yes HER2/CEP17 ratio: 1.46 This ratio is derived by dividing the total number of LSI HER-2/neu signals by the total number of CEP17 signals in at least 20 interphase nuclei with nonoverlapping nuclei in the neoplastic mammary epithelial cells. Cells with no signals or with signals of only one color are disregarded. Method of ratio enumeration: manual count Limitations The Vysis PathVysion Kit is not intended for use to screen for or diagnose breast cancer. It is intended to be used as an adjunct to other prognostic factors currently used to predict disease-free and overall survival in stage Il, node-positive breast cancer patients. In making decisions regarding adjuvant CAF treatment, all other available clinical information should also be taken into consideration, such as tumor size, number of involved lymph nodes, and steroid receptor status. No
+
+--- Page 7 ---
+treatment decision for stage II, node-positive breast cancer patients shouid be based on HER- 2/neu gene amplification status alone. Overview of this test. FDA APPROVED REAGENT PathVysion HER-2 DNA Probe Kit is FDA approved for selection of patients for whom Herceptin therapv is beina considered. These tests were performed in the ', under the direction of Dr.. The resuits of these studies should always be interpreted in the context of the clinical, morphological, and immunophenotypic diagnosis. Gross Dictation:, M.D., Pathologist, Microscopic/Diagnostic Dictation: M.D.. Patholnqist. Final Review: M.D., Pathologist,. Final: M.D., Pathoiogist, 1 Addendum.., Pathologist, . Addendum Final:., Pathologist, '. Addendum: M.D., Pathologist, 1. Addendum Final: M.D., Pathologist, Addendum:, M.D., Pathologist,. Addendum Final:, M.D., Patholoqist, 1 Addendum.., Pathologist,. Addendum Final:, M.D., Pathologist,. Addendum:, M.D., Pathologist,. Addendum Final:., M.D., Pathologist,
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+zcD-o =3 urgical Pathology: Site Siqmoil Cs/sn C18.) JJ u|16|13 UUID:D948972B-8F4F-4C2A-9072-7D4A7E1B58DE  Redacted SURGICAL PATHOLOGY Accession #: Collected: PATHOLOGIC DIAGNOSIS A. COLON, SIGMOID, SIGMOIDECTOMY: - INVASIVE ADENOCARCINOMA - TUMOR SITE: SIGMOID COLON - TUMOR SIZE: - GREATEST DIMENSION: 7.6 CM - ADDITIONAL DIMENSIONS: 3.2 CM X 2 CM - HISTOLOGIC GRADE: LOW-GRADE (WELL TO MODERATELY DIFFERENTIATED) - MICROSCOPIC TUMOR EXTENSION: - TUMOR INVADES THROUGH MUSCULARIS PROPRIA INTO THE SUBSEROSAL ADIPOSE TISSUE - MARGINS: - PROXIMAL, DISTAL AND RADIAL MARGINS UNINVOLVED BY INVASIVE CARCINOMA - DISTANCE OF INVASIVE CARCINOMA FROM CLOSEST MARGIN: 2 MM FROM RADIAL MARGIN - TREATMENT EFFECT: NOT KNOWN - LYMPHOVASCULAR INVASION: PRESENT - PERINEURAL INVASION: NOT IDENTIFIED - TUMOR DEPOSITS: NOT IDENTIFIED - LYMPH NODES: NO METASTATIC CARCINOMA IDENTIFIED IN THIRTEEN LYMPH NODES (O/13) (SEE COMMENT) B. COLON, DESCENDING, NEW PROXIMAL MARGIN, EXCISION: - UNREMARKABLE COLONIC MUCOSA AND WALL C. COLON, DESCENDING, PROXIMAL DONUT, EXCISION: - UNREMARKABLE COLONIC MUCOSA AND WALL D. RECTUM, DISTAL DONUT, EXCISION: - UNREMARKABLE COLONIC MUCOSA AND WALL
+
+--- Page 2 ---
+E. SPLEEN, SPLENECTOMY: - BENIGN PARENCHYMA WITH SUBCAPSULAR HEMORRHAGE PATHOLOGIC STAGING: Primary Tumor (pT): pT3 Regional Lymph Nodes (pN): pN0 Distant Metastasis (pM): Not applicable Pathologic Staging: IIA Staff Pathologist Comment for complete information regarding. Please see surgical report microsatellite instability testing, which reveled positive staining by tumor. for MSH-2, MSH-6, PMS-2, and MLH-1. The specimen was examined twice in order to identify a total of thirteen lymph nodes (0/13). Intraoperative Consultation Intraoperative Gross Consultation Diagnosis Part A: Sigmoid colon, sigmoid colectomy: - Tumor grossly located 2.5 cm from proximal margin - Verbally reported to Staff Pathologist Pathology Resident Pertinent Clinical Information. Pertinent History/Operative Findings: ~ -year-old with history of sigmoid colon cancer. Tattooed sigmoid mass resected with appropriate margins. (greater than 3 cm). Gross Description Specimen Material: A- Sigmoid colectomy - stitch distal, B- Descending colon - new proximal margin- long silk suture, C- Proximal donut from descending colon, D- Distal donut from rectum, E- Spleen The case is received in five parts, each labeled with the patient's name medical record number and given accession number , and it is accompanied by a requisition form labeled with the same.
+
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+name and accession number. Part A: Received fresh labeled with the patient's name and "SIGMOID COLECTOMY GROSS MARGIN, STITCH DISTAL" is a 26.0 cm long section of sigmoid colon with an average diameter of 3-4cm. The specimen is received stapled at both ends, and there is a stitch at the distal end, as oriented by the surgeon. The radial margin is inked black. The serosal surface is smooth. yellow, with abundant attached peri-sigmoidal fat. The mucosa is tan with normal plications. A 7.6 x 3.2 cm tan-brown fungating mass in present within the lumen, located 2.5 cm from the nearest margin (proximal margin). The mass extends grossly to the serosa with a maximal depth of 2.0 cm, and is solid, tan, with a central clear mucinoid area. Multiple bright yellow oval lymph nodes ranging from 0.2 to 1.0 cm are identified. Representative sections are submitted as follows: A1: four presumptive lymph nodes A2: representative section of proximal margin, en face A3: representative section of distal margin, en face A4: uninvolved colon A5-A7: tumor to greatest depth of invasion A8-A11: tumor A12: five lymph nodes A13: five lymph nodes A14: five lymph nodes A15: two lymph nodes A16: four lymph nodes A17: two lymph nodes A18: tumor Part B: Received in formalin labeled with the patient's name and "NEW PROXIMAL MARGIN" is a 1.6 cm long and 1.7 cm diameter piece of tan-pink colon. The long stitch identifies the new proximal margin, as oriented by the surgeon, which is received stapled. The serosa is smooth and pink. The. mucosa is tan, smooth and normally plicated Cassette Summary: B1: margin, en face Part C: Received in formalin labeled "PROXIMAL DONUT FROM DESCENDING COLON" is a 2 x 2 x 0.5 cm tan-pink mucosal donut with attached blue Prolene suture. The mucosal surface is tan and edematous with petechial hemorrhage identified. No discrete masses are found. A representative section is. submitted in C.t Part D: Received in formalin labeled "DISTAL DONUT FROM RECTUM" is a 1 x 1
+
+--- Page 4 ---
+x 0.8 cm tan-pink, mucosal donut. The mucosal surface is edematous and displays petechial hemorrhage. No discrete masses are identitied. A representative section is submitted in D. Part E: Received in formalin labeled "SPLEEN" is a 78 gram, 9.0 x 6.0 x 2.8 cm tan-pink to pink-purple spleen with little attached hilar fat. The capsular surface displays leathery granularity and is gray-maroon, with a 3.2 x 2.2 cm focus of subcapsular, dark red-brown blood. The cut surface displays homogenous tan-red parenchyma without lesions. The cut surface of the subcapsular lesion shows an organizing subcapsular hematoma. No other discrete lesions are identified. Representative sections are submitted in cassettes: E1: subcapsular hematoma E2: parenchyma Pathology Assistant Microscopic Description A-E: Performed. The staff pathologist listed below reviewed this case. Pathology Resident **Electronically Signed Out** Staff Pathologist 0/22/13
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diff --git a/output/text/c473cacd-9593-47a4-9761-fd0bd61f64f6.txt b/output/text/c473cacd-9593-47a4-9761-fd0bd61f64f6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8f1a5a67f8f783f02078de20d220502676d724ed
--- /dev/null
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+PATHOLOGIC DIAGNOSIS: SPECIMEN DESIGNATED RIGHT COLON44 Cm ADENOCARCINOMA, moderately differentiated (3.0 cm). Tumor is located in the cecum, forms a polypoid mass, and is ulcerative. Tumor invades into but not through the muscularis propria. Proximal, distal, and radial resection margins are negative for tumor. Intramural lymphovascular invasion is not identified. Perineural invasion is not identified. Peritumoral response is mild. Residual adenoma is present. Hyperplastic polyps, Multiple (>5) adenomata. Lipoma of ileocecal valve. Fat necrosis, with dystrophic calcifications ("peritoneal mass". Regional lymph nodes (positive:total):0:13. AJCc Classification 6th Edition): T2 NO MX. CLINICAL DATA: History: Biopsy-proven cecal cancer. Operation: Right colectomy. Operative Findings: Localized colon cancer. clinical Diagnosis: Colon cancer. TISSUE SUBMITTED A/1) right colon O.R.CONSULTATION: SPECIMEN LABELED #1 -RIGHT COLONGROSS ONLY Cecal mass 3.0 cm located 16.0 cm from proximal and 43 cm from distal resection margins, grossly. The senior physician certifies that he/she personally conducted a gross and/or microscopic examination of the described specimen(s) and rendered or confirmed the rapid diagnos(es) related thereto. GROSSDESCRIPTION: The specimen is received fresh, labeled with the patients name, unit number, and "#1 - right colon",and consists of one ileocolectomy specimen (measuring 44 cm in total length comprised of ileum (14.8 cm in length x 1.8 cm in diameter) with proximal stapled resection margin measuring 2.9 cm and inked resection margin (measuring 6.2 cm and inked green). There is an attached fragment of yellow lobulated fibroadipose tissue consistent with omentum, measuring 25.0 x 11.0 x 1 cm. The appendix is absent. The serosa has a nodular puckered area measuring 2.5 x 1.5 cm,which is inked black.The specimen is opened (where inked orange) to reveal an ulcerated mass measuring 3.0 x 2.5 x 0.4 cm in the cecum, which is located 16.0 cm from the proximal stapled resection margin, 43 cm from the distal stapled resection margin, and
+
+--- Page 2 ---
+There is a probable lipoma of the 14.0 cm from the radial resection margin. Appendiceal stump is also ileocolonic valve measuring 1.5 x 1.5 x 1.0 cm. There are multiple (greater than located and measures 1.0 cm in diameter. Representative sections of the tumor and normal tissue are submitted to Tumor Bank for special studies. Micro Al: stapled resection margin,2 frags, Micro A2: radial resection margin,l frag, Micro A3-A6: 4 frags, cecal mass, Micro A7: Micro A8: polypoid cecal area,2 frags, Micro A9: representative sections of normal-appearing colonic and ileal mucosa, Micro A10: ileocolonic valve with lipoma,1 frag, Micro Al1: omentum,1 frag Micro A12-A16: twelve lymph node candidates,12 frags, Micro A17: By his/her signature below, the senior physician certifies that he/she personally conducted a microscopic examination ("gross only" exam if so stated) of the described specimen(s) and rendered or confirmed the diagnosis(es) related thereto.
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diff --git a/output/text/c49923f8-459b-4b02-8ccb-58013c7eb1e6.txt b/output/text/c49923f8-459b-4b02-8ccb-58013c7eb1e6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1da54948a1d01c2a497b2dc72d5c3297e19ebf33
--- /dev/null
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+acted SUBMAXILAR RIGHT ADENOPATY: A pinky tissue fragment of 4,2 x 2,5 x 0,5 cm in which a lymph node of 3 cm is. identified. It presents geographic necrotic areas. LYMPH NODE, RIGHT SUBMAXILAR REGION (EXCISION): - DIFFUSE LARGE B-CELL LYMPHOMA, CD20 POSITIVE ASSOCIATED WITH EPSTEIN-BARR VIRUS INFECTION Sections show a lymph node with total replacement of the architecture due to the presence of a diffuse infiltration of atypical lymphoid proliferation, composed of medium to large cells, anaplastic, some multinucleate, with prominent nucleoli and basophilic cytoplasm. This neoplastic infiltration is associated with extents areas of necrosis and fibrosis. The tumor shows an angiocentric growth pattern.. The tumor cells are positive for CD20, CD79a, OCT-2, BOB.1, BCL2, MUM1, LMP1 and CD30, and are negative for CD10, BCL6, CD15, ALK1, CD3, CD4, CD5, CD7 and CD8. The in situ hybridization for the RNA of the Epstein-Barr virus (EBER) is positive. The Ki67 proliferative index is high (70%). I0D O3 PCR IGH FR3: Monoclonal PCR TCR gamma: Polyclonal q4sD|3 OicE (770 D3/31/14
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diff --git a/output/text/c49b282b-0a3c-44f5-a7de-bef9e625a061.txt b/output/text/c49b282b-0a3c-44f5-a7de-bef9e625a061.txt
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index 0000000000000000000000000000000000000000..ba0cd81f56e3efba13bd717a9582a7f2aa96a538
--- /dev/null
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+--- Page 1 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: FMP/SSN: Specimen #: DOb/Age/Sex: JF Race: wHITE Location: Taken: Physician(s) : Received: Reported: SPECIMEN: /cs-0-3 A: SENTINEL LYMPH NODE#1 B: SENTINEL LYMPH NODE #2 Carcm omn, mifiltnstiNg ductel, N05 C: RIGHT BREAST 8500/3 Sit: busst Nos e5v.9 FINAL DIAGNOSIS: A. RIGHT AXILLARY SENTINEL LYMPH NODE #1, BIOPSY: ONE LYMPH NODE NEGATIVE FOR TUMRO BY H&E AND IMMUNOHISTOCHEMISTRY. B. RIGHT AXILLARY SENTINEL LYMPH NODE #2, BIOPSY: ONE LYMPH NODE NEGATIVE FOR TUMRO BY H&E AND IMMUNOHISTOCHEMISTRY. C.  RIGHT BREAST, MASTECTOMY: INFILTRATING DUCTAL CARCINOMA, WELL DIFFERENTIATED BY COMBINED HISTOLOGIC CRITERIA (TUBULES- 2; NUCLEAR GRADE- 2; MITOTIC RATE- 1) -MAXIMUM TUMOR SIZE: 2.4 CM, MEASURED GROSSLY. -DUCTAL CARCINOMA IN SITU, SOLID, CRIBRIFORM, AND MICROPAPILLARYS TYPES, NUCLEAR GRADE 2, WITH FOCAL NECROSIS, COMPRISING 10% OF TUMOR. -NO LYMPH VASCULAR OR PERINEURAL INVASION. -MARGINS NEGATIVE FOR TUMOR. -AJCC STAGE pT2NOMX. ** Report Electronically Signed Out * CLINICAL DIAGNOSIS AND HISTORY: new pleo calcifications. UUID:FDF38AA6-DC65-4043-8277-718AE4790281 TCGA-A2-A0CT-01A-PR PRE-OPERATIVE DIAGNOSIS: Redacted r/o dcis POST-OPERATIVE DIAGNOSIS: Operative Findings: same Post-operative Diagnosis: same Page 1 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 Continued on Next Page
+
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+TOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION: A. Received fresh, labeled with the patient's name, designated "SENTINEL LYMPH NODE #1" and cOnsists of a 0.7 x 0.7 x 0.4 cm lymph node. One half of the node is submitted for the cacp protocol. The remainder is submitted in cassette Al. B. Received in formalin, labeled with the patient's name,. designated "SENTINEL LYMPH NODE #2" and consists of a 2.0 x 1.3 x 0.4 cm fragment of fatty tissue containing a 0.2 cm lymph node. The specimen is bisected and submitted in its entirety for paraffin section in one cassette. c. Received fresh, labeled with the patient's name, "RIGHT BREAST ONE TAG MEDIAL, TWO TAGS SUPERIOR" and cOnsists of a 505.0 designated gram simple mastectomy specimen, measuring 19.7 cm superior to inferior, 19.8 cm medial to lateral, and 2.2 cm anterior to posterior. The overlying ellipse of nipple bearing skin measures 10.5 x 5.2 cm, which is tagged for its abnormalities. Ink code: Superior superficial=blue, inferior superficial-orange, deep-black. Sectioning reveals a 2.4 x 2.4 x 1.7 cm well-circumscribed, tan tumor in the central portion of the upper outer quadrant, 0.6 cm from the deep margin. The tumor is surrounded by dense fibrous tissue, which extends medially to the inner portions of the breast. Within this fibrous tissue in the central portion of the breast (1.0 to 2.0 cm from the tumor and 1.5 cm from the deep margin) is a 0.7 cm Mammomark site without associated mass. Representative sections are submitted in 13 cassettes as follows: C1: Skin, lateral tip.. c2: Tumor, upper outer quadrant. c3: Tumor with deep margin upper outer quadrant. C4: Tumor with deep margin upper outer quadrant.. C5: Fibrous tissue immedial medial to tumor.. C6: Mammomark biopsy site.. c7: Mammomark biopsy site.. c8: Deep margin underlying Mammomark site. c9: Random fibrous tissue lower inner quadrant. C10: Random fibrous tissue upper inner quadrant.. C11: Random fibrofatty tissue upper outer quadrant peripheral.. C12: Random fibrofatty tissue lower outer quadrant.. C13: Cross section of nipple. Page 2 Continued on Next Page. FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
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+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION (continued) : Mirror images of the following sections are submitted for the cBCP protocol: C1, C2, C3, C5, C6, c7, c9, C1o, C11, and c12. Page 3 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 End of Report.
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diff --git a/output/text/c4a6bc84-8c15-4efb-9acb-30078b103113.txt b/output/text/c4a6bc84-8c15-4efb-9acb-30078b103113.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5fe572495bae3dcc9c2041d73abcc64a7f03a5a6
--- /dev/null
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+Results GROSS AND MICROSCOPIC SURGICAL PANEL Specimen Information Collection Date and Time Component Results SURGICAL PANEL: SURGICAL PATHOLOGY REPORT LAB: Phone: Fax. Final Report DIAGNOSIS A) PROSTATE AND URINARY BLADDER, RADICAL CYSTOPROSTATECTOMY: 1. Invasive grade 3 (of 3) urothelial carcinoma, size 7 cm 2. See staging parameters for bladder cancer 3. Incidental foci (two) of prostatic adenocarcinoma (Gleason grade 3 + 3 - score 6) involving the right prostate, sizes 2 mm and 3 mm 4. See staging parameters for prostate cancer also B) RiGht DistAl UretEr, BiOpSy: ICD-O 3  Negative for dysplasia or malignancy CQ rCi nomg,wr0+heJia1, Nos C) Left Distal ureter, Biopsy: 8120|3 Negative for dysplasia or malignancy Sik: bladdcr,tjgom D) RIGHT PELVIC LYMPH NODE, DISSECTION: Five lymph nodes negative for malignancy Cu7.D 3.30iZ RD E) LEFT PELVIC LYMPH NODES, DISSECTION: Four lymph nodes negative for malignancy. F) APPENDIX, INCIDENTAL APPENDECTOMY: Appendix showing no diagnostic change. :. 3LADDER CANCER STAGING PARAMETERS** Case number Final TNM: pT3bN0M0 stage: III MACROSCOPIC SPECIMEN TYPE Radical cystoprostatectomy TUMOR SITE Trigone, Right lateral wall, Anterior wall. TUMOR SIZE Tumor maximum dimension: 7 cm MICROSCOPIC HISTOLOGIC TYPE Urothelial (transitional cell) carcinoma ASSOCIATED EPITHELIAL LESIONS None identified UUID: 2783B3D4-83FA-4E66-A424-715CAC7EFD53 HISTOLOGICAL GRADE TCGA-GC-A3RB-01A-PR Redacted High-grade (Grade 3 of 3 by prior WHO terminology) LYMPHATIC VASCULAR INVASION Indeterminate
+
+--- Page 2 ---
+TUMOR CONFIGURATION Solid/nodule TUMOR EXTENSION Perivesical fat MARGINS Uninvolved by carcinoma Distance of invasive carcinoma to closest margin: 0.5 cm Closest margin(s): Deep radial Uninvolved by carcinoma in situ. PATHOLOGIC STAGING EXTENT OF INVASION pT3b. [Tumor invades perivesical tissue macroscopically i(extravesical maps)] REGIONAL LYMPH NODES pN0. (No lymph node metastasis) Total nodes: 9 Total positive nodes: 0 DISTANT METASTASIS pMO. (No distant metastasis) PATHOLOGIC STAGE Summary Final TNM: pT3bN0M0 stage: III ** The pathologic stage presumes no distant metastasis. PROSTATE CANCER STAGING PARAMETERS Final TNM: pT2aNOM0 stage: I MACROSCOPIC SPECIMEN TYPE  Pelvic lymph node dissection, cystoprostatectomy PSA SCORE Not available MICROSCOPIC HISTOLOGIC TYPE Adenocarcinoma 1.1 J HISTOLOGIC GRADE Gleason grade: 3 + 3 Gleason score: 6 of 10 (primary + secondary) MARGINS Uninvolved by tumor LYMPHATICNASCULAR INVASION Absent  PERINEURAL INVASION Not identified PATHOLOGIC STAGING EXTENT OF INVASION pT2a. (Tumor confined within prostate, involves one half of one lobe or less) Maximal dimension is difficult to determine: see tumor percent.. REGIONAL LYMPH NODES pN0. (No regional lymph node metastasis) Total nodes: 9 Total positive nodes: 0 DISTANT METASTASIS pM0. (No distant metastasis)
+
+--- Page 3 ---
+PATHOLOGIC STAGE Summary Final TNM: pT2aN0M0 2010 stage: I Attending Pathologist: CLINICAL INFORMATION Bladder cancer SPECIMEN/GROSS DESCRIPTION A) SOURCE: Bladder and prostate The specimen is received fresh labeled "bladder and prostate." It consists of an 8 x 7.5 x 5 cm bladder. There is 3 cm of attached right ureter. The ureter appears dilated with a diameter of 0.6 cm. It is obstructed. The ureteral margin (not a true margin) is sectioned and submitted en face. There is 6 cm of attached left ureter. This ureter is patent and measures 0.4 cm in diameter. The ureteral (not a true margin) is sectioned and submitted en face. The attached prostate measures 4 (r-l) x 2.9 (anterior-posterior) x 2.6 (apex-base) cm. The right seminal vesicle measures 2 x 1.5 x 1 cm. The left seminal vesicle measures 2 x 1 x 0.7 cm. The right vas deferens measures 8 cm in length and up to 0.4 cm in diameter. The left vas deferens measures 5 cm in length and up to 0.2 cm in diameter. The right half of the specimen is inked green, the left half Jinked blue and the posterior aspect inked black.. The distal urethral margin is sectioned in a radial fashion and entirely submitted for frozen labeled FS1 and FS2.. INTRAOPERATIVE PATHOLOGY CONSULTATION WITH FROZEN SECTION: "Urethral margin negative" is rendered by! The specimen is opened along the anterior aspect. There is a 7 x 4.1 x 1 cm partially endophytic, partially exophytic mass. The mass is found within the trigone and extends up to a portion of the posterior wall, right Iateral wall and right aspect of the anterior wall. It extends to within 1.5 cm of the distal urethral margins. It appears to obstruct the right ureteral orifice. It is found 1.3 cm from the left ureteral orifice. A representative section of the tumor is sectioned and frozen for possible ancillary studies. It is sectioned. It extends into the bladder wall for a maximum depth of 2.1 cm. The bladder wall measures 2.2 cm and the tumor extends to within 0.1 cm of the right lateral soft tissue margin. The cut surface is tan and firm.. The remaining urothelium is moderately hyperemic and coarsely wrinkled. No additional lesions are noted. The prostate is serially sectioned. The cut surfaces are mottled tan-pink. No obvious tumor is appreciated. The seminal vesicles are sectioned and are grossly unremarkable. The vasa deferentia are sectioned revealing pinpoint unremarkable lumina. A gross photo is taken.. There are no palpable lymph nodes in the attached fat. Representative sections are submitted in 29 cassettes labeled: 1-2.  Frozen section residue, distal urethral margin, sectioned in a radial fashion
+
+--- Page 4 ---
+3. Right and left ureteral margins (not true margins). en face 4. Obstructed right ureteral orifice. 5. Tumor and posterior walls 6-7. Tumor's greatest depth and nearest soft tissue margin 8. Tumor at trigone 9. Tumor anterior wall 10. Left ureteral orifice 11. Uninvolved left urothelium 12. Uninvolved anterior urothelium 13.  Uninvolved posterior urothelium 14-17. Right prostate, apex to base (cassette 17 includes longitudina! section, seminal vesicle) 18-22. Left prostate, apex to base (cassette 22 includes longitudinal sections, seminal vesicle) 23. Vasa deferentia margins, en face The remainder of the apparent prostate is submitted as follows: 24-25. Portion of right prostate 26 Portion of possible right prostate and bladder tumor 27. Portion of possible right prostate and bladder tumor 28. Portion of left prostate 29. Portion of possible left prostate (includes portion of bladder and tumor) B) SOURCE: Distal right ureter Labeled "right distal ureter' is a 0.6 cm in length cylindrical portion of tissue measuring 0.8 cm in diameter. It is submitted as received in one chuck for frozen section diagnosis.. INTRAOPERATIVE PATHOLOGY CONSULTATION WITH FROZEN SECTION: "Negative" is rendered by C) SOURCE: Left distal ureter Labeled "left distal ureter' is a tan-pink cylindrical 0.6 cm in length x 0.6 cm in diameter portion of tissue. It is entirely submitted on for frozen section diagnosis INTRAOPERATIVE PATHOLOGY CONSULTATION WITH FROZEN SECTION: "Negative" is rendered by D) SOURCE: Lymph nodes, right pelvic. Labeled "right pelvic lymph nodes" are several yellow-tan ragged fatty tissues aggregating 5 x 4 x 1 cm. Five lymph nodes are identified ranging from 0.4-2.8 cm in greatest dimension. The nodes are submitted in four cassettes as follows:  Three nodes 2.  One node 3.4. One node E) SOURCE: Lymph nodes, left pelvic. Labeled "left pelvic lymph nodes" is a 3 x 2 x 2 cm portion of yellow-tan ragged fatty tissue. Four lymph nodes are identified ranging from 0.9-3.5 cm in greatest dimension. The nodes are submitted in five cassettes as follows: 1. One node 2-3. One node 4. One node
+
+--- Page 5 ---
+5. One node F) SOURCE: Appendix Labeled "appendix" is an intact vermiform appendix measuring 2.8 cm in. length averaging 0.5 cm in diameter with attached mesoappendiceal fat  measuring 2 x 0.5 cm. The serosal surface is pink-tan and smooth with an. unremarkable lumen without masses, perforations or fecaliths identified.. Representative sections to include the proximal margin (inked) are. submitted in a single cassette. This case is accessioned in Gross dictation by: MICROSCOPIC A-F) The microscopic appearance substantiates the diagnosis. Dictation by: transcribed by Interpreted at F COLLECTED: ACCESSIONED: SIGNED: Lab and Collection GROSS AND MICROSCOPIC SURGICAL PANEL  Information  Lab and Collection Result History GROSS AND MICROSCOPIC SURGICAL PANEL >rder Result History Report. Lab Status Order Complete [3] Reviewed by List on Result Information  Result Date and Time Status Provider Status Final result Ordered Lab Information Order Details Parent Order ID Child Order ID Entry Date Specimen Information 3pecmen Source Collection Date Collection Time Other Audit Trail
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diff --git a/output/text/c4ad7506-5b1d-448d-a912-4993a5523504.txt b/output/text/c4ad7506-5b1d-448d-a912-4993a5523504.txt
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index 0000000000000000000000000000000000000000..fd1cdae40be133c43ad6787d034df923fb4c672d
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+
+--- Page 1 ---
+P.29/33 YMRH:NODE #1, LEfT AXILLA, BiOpSy - PHNODE WITH mETASTATIC CARCINOMA (1/1). rB  MEtASTATic:fOcus Measures 2.1 mm (On gLASS sLiDe), nO eXTRaCApSULAR EXTenSiOn PART 3;BREASTS REFT, TOTAL MASTECTOMY - B.THE TONORimEASURES 2.4:Cm (GROSS MEASUREmeNT), TImOR iS LOCATED CENTRALLY. *C; FNOTJINGHAmiGrADe-1/3 (tUBuLES fORmATiON 2, NUCLEAR GRADE 2, mITOtIC AcTivITy 1; tOTAL NOTTINGHAM SCORE S/9). . D. JNO LYMPHOVASCULAR INVASION.IS SEEN. E..  DUCTAL CARCJNOMA IN:SITU, CRIBRIFORM AND SOLID TYPE, NUCLEAR GRADE 2 COMPRISING 40% OF TOTAL: TUMOR VOLUmE PRESENT in ASSOcIATIOn WITH inVaSiVE CArCINOMA. F. MARGINS:-AEL MARGINS OF RESECTION ARE FREE OF INVASIVE AS WELL AS IN SITU CARCINOMA. CLOSEST POSTERIOR MARGIN IS 1.5 Cm AWAY. G. LOBULAR NEOPLASiA(ATyPICAL LOBULAR HYPERPLASIA AND LOBULAR CARCINOMA iN SITU) AssOCIATED WITH CALCIFICATIONS. H. ATYPICAL DUCTAL HYPERPLASIA WITH ASSOCIATEO CALCIFICATIONS AND PREVIOUS BIOPSY SiTE CHAngES. I. UppeR Outer quaDrAnt: BenIgn Breast TISsUE. LOwer OUteR quaDrAnT: ATypICal Ductal hypERpLASiA, FiBrOcySTiC ChAnge AND J. SCLEROSING ADENOSIS. K. UppeR INNeR QUADRANT: BENIgn BREASt TISSUE. LOWER INNER QUADRANT: LOBULAR NEOPLASIA AND FIBROCYSTIC CHANGE M. Skin, nipple: no tumor seen. N. Er positive, pr positive. her-2/neu positive. refer tO PArt 4: SEntinel Lymph nODe #3, LEft`AxiLLA, biOpsy -- ONE LyMPh NODE WITH METASTATiC. CARCiNOMA (1/1). B.  METASTATIC fOCUS MEASURES 7 MM (ON GLASS.SLIDE), EXTRACAPSULAR EXTENSION IS iDENTIFIED AS WELL, Part 5: Sentinel Lymph nOde #4, Left axillA, Biopsy - CASE SYNOPSIS: SYNOPTIC - PRIMARy INVASIVE CARCINOMA OF BREAST 1cs-0 -3 LAterality: Caunomu mfiYmuHnz duchf,nos 85oo/3 Lefl Sin : busst Nos c50.9 PROCEDURE:  Simple mastectomy 3/1|n h LOCATION: Central. subareolar SIZE OF TUMOR:  Maximum dirnension invasivc component: 2.4 cm. MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: No TumOR Type (invasiva component): Ductal adenocarcinoma, NOs, Tubular carcinoma NOTTiNGHAM SCORE: Nuclear grade: 2 Tubulc formation: 2 Mitotic activity score: 1 UUID:28231C78-64EE-49AC-B7AB-98ADDDDCC17C Total Nottingham score: 5 TCGA-BH-A0EA-01A-PR Redacted Nottingham grade (1, 2, 3): 1 ANGIOLYMPHATIC INVASION: DErmal Lymphatic invasion: No No CALCifIcATiOn: Yes, malignant zones Tumor type, in situ: Cribrifonm Solid  DCIS admixed with invasive carcinoma LCIS:  Percent of tumor.occupied-by,in situ component: 40.%.. SURGICAL MARGINS INVOLVED BY,INVASIVE COMPONENT No SURG MARGINS INVOLVED-BY IN SITU COMPONENT: No PageT's DisEaSe Of nIppLE Lymph noDes PositIve:: Lymph nodes examineD: METHOD(S) OF LYMPH:NODE EXAMINATIOt SENTINEL NODE METASTASIS:R ONLY.KERATIN POSITIVE CELLS;ARE:R SIZE OF NODAL METASTASES: Djameteriotllarges LYMPH NODE METASTASIS(-ES).WITHEXTRACAPSULAREXT SIG Yes
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diff --git a/output/text/c4c567e5-139e-4848-93be-f020e5db2a59.txt b/output/text/c4c567e5-139e-4848-93be-f020e5db2a59.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5fc0e63aa7423a7f393f929822ec2557a826e42a
--- /dev/null
+++ b/output/text/c4c567e5-139e-4848-93be-f020e5db2a59.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+I<D-O3 CGA-GS-A9U3-01A-PR Reda 96s0|3 Site: iDympsh nde, uguinal C 774 LEFT INGUINAL LYMPH NODE: DJ33i/14 We receive a lymph node measuring 3,5 x 3,5 x 2,8 cm.. INGUINAL LYMPH NODE (BIOPSY): - DIFFUSE LARGE B-CELL LYMPHOMA, CD20 POSITIVE The lymph node shows a diffuse and partially nodular lymphoid infiltration composed by large centroblastic cells, accompanied by abundant small lymphocytes, histiocytes and plasma cells. The atypical cells are positive for CD20, BCL2, BCL6 and IgD, and are negative for CD10 and MUM1. There is Kappa light chain restriction. The small accompanying lymphocytes are CD3positive. The Ki-67 proliferative index is 50-60%. PCR BCL2 : Rearranged bw 1a/sf13
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diff --git a/output/text/c4d55b9d-c5c0-4786-859e-08ccbd3e358d.txt b/output/text/c4d55b9d-c5c0-4786-859e-08ccbd3e358d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..000c15bf1e3dafcd648c0727412656deaa764804
--- /dev/null
+++ b/output/text/c4d55b9d-c5c0-4786-859e-08ccbd3e358d.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:03DC554E-1F63-4775-B33C-8941E7950D3D TCGA-IG-A51D-01A-PR Redacted 1es-0 - 3 Cartnons,sgutmns ell,n0s 8o7o/3 Gross Description: C4cF: Site: ssophaguw,prxnal yhid c/5.3 Microscopic Description: Path. lsophigur. curvical c/s. 0 Diagnosis Details: 1/8/12 Comments: Formatted Path Reports: ESOPHAGUS TISSUE CHECKLIST Specimen type: Resection of esophagus. Tumor site: Cervical esophagus Tumor size: 5.5 x 5 x 1 cm Histologic type: Squamous cell carcinoma Histologic grade: Moderately differentiated Tumor extent: Lamina propria or submucosa. Lymph nodes: 1/1 positive for metastasis (Intraabdominal 1/1) Lymphatic invasion: Not specified. Venous invasion: Not specified Margins: Not specified Evidence of neo-adjuvant treatment: Not specified. Additional pathologic findings: Not specified Comments: None
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diff --git a/output/text/c4e97c21-86b0-4657-aa36-a6857e9f595f.txt b/output/text/c4e97c21-86b0-4657-aa36-a6857e9f595f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..32e7e1ede78ed0c92119d2c01e035d253e88c9e7
--- /dev/null
+++ b/output/text/c4e97c21-86b0-4657-aa36-a6857e9f595f.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:DD5295D4-3896-4AA5-AF7S-30AEA45D1652 TCGA-A2-A3XS-01A-PR Redacted SURGICAL PATHOLOGY REPORT Patient: Specimen #: FMP/SSN : DOB/Age/Sex : (Age: Taken: Rac Location: Received: Physician(s) : Reported: **AMENDED** icd-o3 SPECIMEN: carinomg, 1nF s+a+ng A: LEFT BREAST LUMPECTOMY du<+1,n0s g 8 sod3 B: NEW MEDIAL MARGIN, LEFT BREAST C: SENTINEL LYMPH NODE #1 D: AXILLARY CONTENTS s Site: brecst, nos 3-Z3'Z eD c 50.q FINAL DIAGNOSIS: A. BREAST, LEFT, LUMPECTOMY: INFILTRATING (INVASIVE) )AND INTRADUCTAL CARCINOMA, COMEDO-TYPE BLOOM-RICHARDSON GRADE 93+3+3.  TUMOR INVOLVEMENT AT INFERIOR, SUPERIOR, AND ANTERIOR MARGINS. SPECIAL STAINS PENDING, ADDENDUM TO FOLLOW. B. BREAST, LEFT NEW MEDIAL MARGIN, BIOPSY:  HIGH GRADE INTRADUCTAL CARCINOMA, COMEDO-TYPE, BLOOM RICHARDSON GRADE 93+3+3. -TUMOR INVOLVMENT PRESENT AT MARGIN C. LYMPH NODE, SENTINEL LYMPH NODE #1, BIOPSY: POSITIVE FOR METASTATIC CARCINOMA. - CYTOKERATIN STAIN POSITIVE FOR METASTATIC CARCINOMA. D. SOFT TISSUE, AXILLARY CONTENTS, BIOPSY: - NO EVIDENCE OF MALIGNANCY. AJCC PATHOLOGIC STAGING: pT2 pN1c pMX COMMENT : AMENDMENT Case amended by Dr in the absence of the primary pathologist, Dr to report results of HER2 analysis by immunohistochemistry Hercep Test) : HER2: WEAKLY POSITIVE (2+) NOTE: HER2 by FIsH analysis previously performed on 1. FISH: Not amplified (1.3). Page 1 Continued on Next Page FOR OFFICIAL USE ONLY  PERSONAL DATA
+
+--- Page 2 ---
+FOR SURGICAL PATHOLOGY REPORT Specimen #: Patient: FINAL DIAGNOSIS (continued): CLINICAL DIAGNOSIS AND HISTORY: -year-old with diagnosis of left breast cancer. GROSS DESCRIPTION: A. LEFT BREAsT LUMPEcTOMy received fresh labeled with the patient's name and designated "LEFT BREAST LUMPECTOMy" is a piece of fatty tissue, 8.0 x 5.0 x 6.5 x 1.8 cm, impaled with a needle localization wire. The specimen is oriented with sutures (short-superior, long-lateral) and is inked as follows: Red-medial and lateral, blue-superior, green-inferior, yellow-anterior, black-posterior. The needle localization wire enters the specimen at the lateral margin. The tip of the wire is embedded in the mid portion of the specimen. The accompanying specimen radiograph is reviewed and shows numerous calcifications in the area of the wire localization. The specimen is serially sectioned, medial to lateral, revealing a poorly differentiated mass, 3.0 cm in greatest dimension, corresponding to the area of radiographic abnormality. The mass is firm and nodular, and contains at least two well-circumscribed masses with a tan, gritty cut. surface. The largest of these well-circumscribed masses measures 1.2 cm in greatest dimension. The 3.0 cm mass abuts the superior and inferior. margins. The remaining tissue is variably fatty and fibrous; the fibrous tissue is firm and nodular in some areas. Sections of tumor and grossly normal fibrous tissue are harvested for the rotocol. Matched sections for histology are as follows:. A1-A2: Tumor. A3: Grossly normal fibrous tissue, medial portion of specimen.. A4: Medial most margin of specimen.. A5-A6: Full thickness cross section. A7-A9: Full thickness cross section. A10-A12: Full thickness cross section. A13-A15: Full thickness cross section.. A16-A18: Full thickness  cross section. A19-A21: Full thickness  cross section. A22-A23: Ful1 thickness s cross section. A24-A25: Full thickness cross section. Page 2 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF
+
+--- Page 3 ---
+FOR OFFICIAL USE ONLY - PBRSONAL DATA - PRIVACY ACT Or SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION (continued) : A26-A27: Ful1 thickness cross section. A28-A30: Full thickness cross section. A31-A33: Full thickness cross section. A34-A35: Full thickness cross section. A36-A38: Ful1 thickness cross section. 38CFNS. B. NEW MEDIAL MARGIN, LEFT BREAST received in formalin labeled with the patient's name and designated "NEW MEDIAL MARGIN, LEFT BREAST" are two fragments of yellow/tan fibrofatty soft tissue. The largest fragment measures 7.5 x 3.0 x 2.0 cm and the smaller tissue fragment measures 4.5 x 2.5 x 1.3 cm. The specimens are received unoriented. The specimens consist of lobulated, yellow/tan soft tissue with areas of interdigitating white, fibrous areas. The outer surface of each specimen is inked in black. Cross sectioning through both tissue fragments demonstrates homogeneous, yellow, lobulated soft tissue with interdigitating white, fibrous strands. No discrete masses or nodules are found. Cassette key: B1-B8: Largest tissue fragment. B9-B15: Smaller tissue fragment.. C. SENTINEL LYMPH NODE NUMBER ONE received in formalin labeled with the patient's name and designated "SENTINAL LYMPH NODE NUMBER ONE" is a 0.7 grossly apparent lymph node and a small amount of adherent fat. A small. cm portion of the node is harvested for the protocol. The remaining lymph node is submitted. D. AxILLARy coNrENTs received in formalin labeled with the patient's name and designated "AxILLARy coNTENTs" are three fragments of fibrofatty soft tissue measuring 3.5 x 3.5 x 2.0 cm in aggregate. Sectioning through the specimen demonstrates a mottled, yellow/red fibrofatty soft tissue. Cassette key: D1-D2: Largest tissue fragment. D3: Second largest tissue fragment. D4: Remaining tissue fragment. Page 3 End of Repc FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY A
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diff --git a/output/text/c510cc7b-cf55-427e-973f-b19a07b45e3e.txt b/output/text/c510cc7b-cf55-427e-973f-b19a07b45e3e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4a8b88b7c3e365f8726b4f96fc9839ca5700e16e
--- /dev/null
+++ b/output/text/c510cc7b-cf55-427e-973f-b19a07b45e3e.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:6F87A794-C3E7-4501-A844-CF6589C3D32C TCGA-AN-A04A-01A-PR  Redacted TSS Patient ID: Case #: DOB: Sex: Female Ethnicity (Race):. Cancer Sample Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma. Date of Procurement:. inatomic Site: Left Breast Tumor location: Primary Tissue Specification: Tumor Specimen Matrix: Tissue Specimen Format: OCT Container: block Type of Procurement: Radical mastectomy Grade: 2. T Stage:2 N Stage: 2 M Stage: 0 Treatment: none. Treatment Details: n/a.  Normal Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw Matrix: Blood Specimen Format: frozen Container: tube Date of Procurement:. 1cs-0-3 covcionu, nifiI+rafny duct,nvs 85oof3 Site: breast, Nvs C50. h. 10/2f Ijojar/t
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diff --git a/output/text/c5313bfc-6f2b-422a-9e56-8deb23cbdb1a.txt b/output/text/c5313bfc-6f2b-422a-9e56-8deb23cbdb1a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5df28d686ec32b41a7269e653f00beb93abd22ca
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:7D7514B8-A5CE-48D5-8883-BC06F1718696 IcD o 3 TCGA-V4-A9ET-01A-PR Redacted Cell imige 8776|3 Enucleation of the right eye. po#veaItrot Cb94 UJ q/16|i4 Macroscopy The eyeball measures 26 mm in diameter with a segment of optic nerve of 5 mm. At the section, a tumor located at the inferior part of the eyeball and measuring 18 mm is observed. Tissue specimens are taken for cryopreservation prior fixation.. Su path dio crponcy frm fr.  Microscopy Lpithebivrid aud spendle cell raHo. The tumor observed macroscopically presents the histological aspect of an uveal melanoma. This tumor is composed of epithelioid (50%) and of fusiform cells (50%) The cell atypias are severe. Presence of melanin. The mitotic activity is low (2 mitoses per 10 HPF). There is a focal infiltration of the ciliary body and of the inner part of the sclera, on a thickness of about 1 mm. The tumor is at distance from the optic nerve which is free on its entire course. The cut end of the optic nerve and the meningeal sheath are also free of tumor. Conclusion Uveal melanoma composed of epithelioid and of fusiform cells. Tumor size: 18X10 mm main lines. Mitotic activity: low Focal tumor infiltration of the ciliary body and of the 1/3 inner part of the sclera, on a space of about 1 mm, without extra-scleral extension.. Optic nerve on its entire course, optic nerve cut end and meningeal sheaths free of tumor. 12/30/
+
+--- Page 2 ---
+V4.00 TCGA Pathologic Diagnosis Discrepancy Form. Instxuctions: The TCGA Pathologic Diagnosis Discrepancy Form should be completed when the pathologic diagnosis documented on the initial pathology report for a case submitted for TcGA is inconsistent with the diagnosis provided on the Case Quality Control Form completed for the submitted case. Tissue Source Site (TSS): . TSS Identifier: ..  TSS Unique Patient Identifier: . Completed By (Interviewer Name on OpenClinica): - Completed Date:. Diagnosis Information # Data Element Entry Alternatives Working Instructions 50% epithelioid cells Provide the diagnosis/histologic subtype(s) documented on  Pathologic Diagnosis the initial pathology report for this case. If the histology for  Provided on Initial this case is mixed, provide all listed subtypes. 50% spindle cells Pathology Report Histologic features of 61-90% spindle cells Provide the histologic features selected on the TCGA Cas Quality Control Form completed for this case.  the sample provided for TCGA, as reflected 1-30% epithelioid cells  on the CQCF. Discrepancy between Pathology Report and Case Quality Control Form Provide the reason for. Provide a reason describing why the diagnosis on the initial  the discrepancy The section of the frozen sample used for sending  pathology report for this case is not consistent with the.  between the pathology to TCGA corresponds to a section of the tumor  diagnosis selected on the TCGA Case Quality Control Form. report and the TCGA where the epithelioid part is predominant.. Case Quality Control Form. The percentages mentioned on the initial Pathology Report correspond to an average on the whole embedded sections used for establish the Pathology Report.  Name of TSS Reviewing Provide the name of the pathologist who reviewed this case.  Pathologist or for TCGA.  Biorepository Director I acknowledge that the above information provided by my institution is true and correct and has been quality controlled.. TSS Reviewing Pathologist or Biorepository Director Date I acknowledge that the above information provided by my institution is true and correct and has been quality controlled. The Attending Pathologist or the.  Department Chairman has been informed or is aware of the above discrepancy in diagnoses.. Principal Investigator Signature Date
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diff --git a/output/text/c55db163-447a-495b-b2c4-351384942880.txt b/output/text/c55db163-447a-495b-b2c4-351384942880.txt
new file mode 100644
index 0000000000000000000000000000000000000000..cf45e50dbc8c41830812e93c8e78fcda33ac7fbf
--- /dev/null
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@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+UUID: 25CD89AC-052F-4B9F-AE1C-B0824A7A5145 TCgA-C8-A3M8-01A-pR Redacted Form Revised Clinical Case Report. (For Collection of Cancerous Tissue). 1co-0-3 Curcnmn nfHns$ng lobuln,n0s 853f3 Sit:5us+ nvs c5o.9 .. Informed Consent I personally informed this patient that a specimen(s) would be collected to be used for research. purposes. I reviewed the RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the. consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name ot Physician or Study Coordinator. Signature 'Date Clinical Information. GENERAL INFORMATION Date of Birth (mm/dd/yyyy). Height  Marital Status Race Temperature 1m 58  Single  Married 7 Gender Weight  Divorced  Widow  Blood Pressure Heart Rate ~ Female 56 ka T016  Male 0 HISTORY OF PRESENT ILLNESS Chief Complaints: pcim in tte liqhf-[xea]. Symptoms: Performance Scale (Karnofsky Score):  100 Asymptomatic  80-90 Symptomatic but Fully Ambulatory  60-70 Symptomatic, in bed less than 50% of day.  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden  20-30 Bed Ridden CURRENT MEDICATIONS Drug Dose Route Frequency Date (mm/dd/yyyy) To / To 1 To To 1 To
+
+--- Page 2 ---
+PAST MEDICAL HISTORY Treatment Status Diagnosis Date Diagnosis/Disease/Disorder/Injury OB/GYN HISTORY Date of First Menses # of Pregnancies Menopausal Status 0 3  Pre-menopausal yecr yd Date of Last Menses # of Live Births  Peri-Menopausal pears old c 3 Post-menopausa! Birth Control:  Condom  Oral Contraceptive IUD  Hormone Replacement Therapy:  Other: SOCIAL HISTORY Occupation: Environmental Hazards: Smoking History  Packs/day Duration When Quit Current Status TYPE O YES $NO (yrs) (yr) Alcohol Consumption TYPE Drinks/day Duration When Quit Current Status  YES NO yrs (yr) Drug Use Current Status TYPE Frequency Duration When Quit  YES NO (yrs) (yr) FAMILY MEDICAL HISTORY Relative Diagnosis Age of Diagnosis LAB DATA Test Result Date Test Result Date HIV Negative  Positive: CEA  Negative  Positive: Hep B Negative  Positive: CA 15-3  Negative  Positive: Hep C  Negative CA 19-9  Negative  Positive:  Positive: AFP  Negative  Positive: PSA  Negative  Positive: Other: Other:  Negative Positive:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+DIAGNOSTIC STUDIES Study Results Date Ultrasound X-Ray CT Endoscopy MRI Biopsy  CaRciNm) CLINICAL DIAGNOSIS Preoperative Clinical Diagnosis Location of Suspected Involved Lymph Nodes Location of Suspected Distant Metastasis Clinical Staging Date of Diagnosis TA No Me Stage: T Treatment Information SURGICAL TREATMENT Procedure Date of Procedure Modihed Ladcal. Mastretoyy  Primary Tumof Organ Detailed Location Size leit bReact Tumas nyjpeRcrleR zuacdecnSy x12x Lcm Extenslon of Tumor Lymph Nodes Description Location of Lymph Nodes # of Lymph Nodes Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Organ Detailed Location Size Surgical Staging NOMO Stage: NEOADJUVENT THERAPY (Chemo, Radiation, Immuno, Hormonal, or Molecular) Drug/Treatment Dose Route Freguency Date (mm/dd/yyyy) To / To 1 1 To 1 / 1 To / 1 To 1 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Date ime Collected by: Date:  Time Preserved by:  .-- SPECIMEN TYPE (# of samples provided) Blood/Serum/Plasma Slide Frozen  Paraffin Block Diseased Normal Diseased Normal Diseased Normal Diseased Normal 3 2 2 3 2 3  Time to Formalin Time to LN2  Time to LN2 T3 min min 12 min PATHOLOGICAL DESCRIPTION Primary Tumor Extension of Tumor Distance to NAT Organ Size Jeet baest Timcr 6 cm Lymph Nodes Location # Examined # Metastasized Distant Metastasis Detailed Location Size Organ Pathological Staging pT 1 nO mo Stage: Notes:
+
+--- Page 5 ---
+Microscopic Description Histological Pattern Cell Distribution + Structural Pattern + Diffuse  Streaming  Mosaic  Storiform  Necrosis Fibrosis  Lymphocytic Infiltration Palisading Vascular Invasion Cystic Degeneration Clusterized Bleeding  Alveolar Formation Myxoid Change  Indian File Psammoma/Calcification Cellular Differentiation  Squamous +- Adenomatous +  Sarcomatous Lymphomatous +  Squamoid Cell Glandular cell Round Cell Large Cell Spindle Cell Cell Stratification Fibroblast Small Cell  Keratin Secretion Osteoblast  RS Cell/RS Like Desmosome Intracyt. Vacuole Lipoblast Inflam. Cell Pearl Gland formation Myoblast  Plasma Cell Cellular Differentiation:  Well  Moderate  Poor  Nuclear Appearance Nuclear Atypla: 0 1 II III  Aniso Nucleosis Hyperchromatism  Nucleolar Prominent  Multinucleated Giant Cell. Mitotic Activity Nuclear Grade: IHC Data  Marker Result Value Date ER  Negative   Positive PR Negative Positive Her-2/neu  Negative  Positive B-Cell Marker  Negative Positive T-Cell Marker  Negative  Positive Other:  Negative  Positive Other:  Negative  Positive Final Pathology Report Histological Diagnosis: Mocle raTelu cliele neuxTier Eeg Grade: Comments: PrincipaKInvestigator Pathologist Date 5
+
+--- Page 6 ---
+cOnsolIdated DiagnOstic pathoLOgy foRm* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION STRUCTURALPATTERN  Diffuse  Streaming Mosaic  Storiform  Necrosis Fibrosis  Lymphocytic Infiltration Palisading Vascular Invasion Cystic Degeneration Clusterized Bleeding  Alveolar Formation Myxoid Change Indian File Psammoma/Calcification 2. Cellular features: Sguamouy + Adenomatous +- Sarcomatous -Lymphomatous  Squamoid Cell Glandular cel! Round Cell Large Cell Spindic Cell Cell Stratification Fibroblast Small Cell Keratin Secretion Osteoblast RS Ce!l/RS Like  Desmosome Intracyt. Vacuole.  Lipoblast  Inflam. Cell  Gland formation  Myoblast Plasma Cell  Pearl Otherwise Specified: D 6O7 D2687 D31O 2. Cellular Differentilation: Well Moderately Poor Nuclear Atypia: 118 Nuckear Appearnnce  Aniso Nucleosis Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity Nuclear Grade MMrCemd Lensshasisity Comments: Data Director, Research Pathology PATHOLOGIST STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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diff --git a/output/text/c56ee82a-b53c-4ba7-a8cb-16f45429ebc3.txt b/output/text/c56ee82a-b53c-4ba7-a8cb-16f45429ebc3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9bb684bbc9fe844576b002759638fd2db75a8946
--- /dev/null
+++ b/output/text/c56ee82a-b53c-4ba7-a8cb-16f45429ebc3.txt
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+
+--- Page 1 ---
+Collection Date: FINAL DIAGNOSIS: tgD-O.3 Part 1: kidney, right, inferior lower pole, partial nephrectomy -- A.  Renal cell Carcinoma, Clear CeLl type. B. The tumor measures 0.4 Cm in greatest DimensiOn. cell 8Q60/3 c. Fuhrman nucLeaR grADe iS 1 Out Of 4. D. RENAL PARENCHYMAL MARGIN IS NEGATIVE FOR TUMOR. Ce49 E. PATHOLOGICAL STAGE: pT1aNxMx.  5/16/3 Part 2: soft tissue, fat overlying tumor, biopsy -- Benign fibroaDipose tissue, negative for tumor. Part 3: Kidney, Right, partial nephrectomy -- A.  RENAL CELL CARCINOMA, WITH OVERLAPPING FEATURES OF PAPILLARY RENAL CELL CARCINOMA AnD MucinOus TuBuLAR anD SpinDLe CeLl Carcinoma  (See Comment). B. The Carcinoma measures 4.3 Cm in greatest Dimension. C. The CarcinomA Is COnfined to the KIdney. UUID:DE51CCE8-C664-4F04-92C2-367E5270C4B3 D. LymPhOVASCULAR iNVASiON IS NOt IDENTIFIED. TCGA-B1-A657-01A-PR Redacted E. FUHrman nUCLeAR GRADE 2/4. F. All margiNs aRe negativE. G. PathOLOgIC STAgE; pT1b nX mX. COMMENT: This tumor has an interesting morphology with a paplliary architecture but in areas has elongated and angulated tubular. growth pattern reminiscent of mucinous and tubular spindle cell carcinoma. No distinct mucin is identified and there are many foam cells in the background. immunostains were performed and show that tunor cells are positive for CK7 and. racemase, focaily positive for CD10 and negative for CAf. While we favor this to represent a papillary renal cell carclnoma, our differential diagnosis aiso includes an unusual variant of mucinous tubular spndle cell carcinoma. CASE SYNOPSIS: 419/13 Per TsS, popillmy = 96% SyNOpTIC DATA - PRImARy KIDnEy TUmORS SPECIMEN TYPE: Partial nephrectomy LATERALITY: Right TUMOR SITE: Not specified FOCALITY: Unifocal TUMOR SIZE: Greatest dimension: 5.0 cm MAcrOsCOpic eXTent Of TumOR: Tumor limited to kidney. HISTOLOGIC TYPE: Papillary renal cell carcinoma HISTOLOGIC GRADE (Fuhrman Nuclear Grade): G2 PATHOLOGIC STAGING (pTNM): pT1b pNX Number of regional lymph nodes examined: 0 pMX MARGINS:  Margins uninvolved by invasive carcinoma ADRENAL GLAND: Not present LYMPH-VASCULAR INVASION (LVI): Absent/not identified ADDITIONAL PATHOLOGIC FINDINGS: None identified
+
+--- Page 2 ---
+SPECIAL PROCEDURES: In Situ Procedure Interpretation SPECIAL PROCEDURE REPORT MOLECULAR ANATOMIC PATHOLOGY FLUORESCENCE iN SITU HYBRIDIZATION ANALYSIS Comment:  Fluorescent in-situ hybridization (FIsH) tests show monosomy of chromosome 1 and 2 in approximately 66% and 54% of the tumor cells. Trisomy of chromosome 17 is seen in 25% of tumor cells.. This FiSH profile is suggestive of a mucinous tubular and spindle cell carcinoma. However a papillary renal cell. carcinoma cannot be ruled out. Specimen type: Renal tumor. Result: 2 Signals 3 or more Signals 1 Signal 40 (65.6%) 21 (34.48) 0 (0%) CEP1 CEp2 36 (53.7%) 29 (43.3%) 2 (3.08) 44 (72.18) 4 (6.68) CEp7 13 (21.38) CEp17 11 (18.0%) 35 (57.48) 15 (24.68) Abnormality detected: Monosomy of chromosome 1 and 2 is seen In approximately 66% and 54% of the tumor colls. Trisomy of chromosome 17 is seen in 25% of tumor cells. Interpretation guidelines: Chromosomal losses are considered significant if present in greater than 30% of cells. The loss is indeterminate if present in.  20-30% of cases. The loss is considered artifactual if seen in less than 20% of cases.. Chromosomal gains are considered significant if present in greater than 20% of cells. The gain is considered artifactual if seen in less than 20% of cases. Results Probes used: CEP1 (1p11.1q11.1), CEP2 (2p11.1q11.2), CEP7 (7p11.1q11.1), CEP17 (17p11.1q11.1). At least 25 cells are analyzed. The signal distribution for targeted toci of renal carcinoma is recorded. if the test results are not. consistent with the clinical findings, and/or diagnostic, a consultation between pathologist and treating physician is warranted.. Department of Pathology, This test was developed and its performance characteristics determined by the. as required by the CLIA '88 regulations. References 1.  Kovacs G, et al. Cytogenetics of papillary renal cell tumors. Genes Chrom Cancer 3:249-255, 1991.. Bugert P, Gaul C, Weber K, Herbers J, Akhtar M, Ljungberg B, Kovacs G. Specific genetic changes of diagnostic importance. in chromophobe renal cell carcinomas. Lab Invest. 1997 Feb;76(2):203-8. 3.  Hughson MD, Dickman K, Bigler SA, Meloni AM, Sandberg AA. Clear-cell and papillary carcinoma of the kidney: an analysis of chromosome 3, 7, and 17 abnormalities by microsatellite amplification, cytogenetics, and fluorescence in situ hybridization.. Cancer Genet Cytogenet. 1998 Oct 15;106(2):93-104. 4.  Reuter V & Presti JC. Contemporary approach to the ciassification of renal epithelial tumors. Semin Oncol 27:124-137, 2000. 5.  Salama ME, Worsham MJ, DePeralta-Venturina M. Malignant papillary renal tumors with extensive clear cell change: a  molecular analysis by microsatellite analysis and fluorescence in situ hybridization. Arch Pathol Lab Med. 2003 Sep;127(9):1176-81. Brunelli M, Eble JN, Zhang S, Martignoni G, Delahunt B, Cheng L. Eosinophilic and classic chromophobe renal cell carcinomas have similar frequent losses of muitiple chromosomes from among chromosomes 1, 2, 6, 10, and 17, and this pattern of genetic abnormality is not present in renal oncocytoma. Mod Pathol 2005; 18 2: 161-169.. 4/9113
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diff --git a/output/text/c58cba9c-3c9b-4498-ada2-eb5d42808ae0.txt b/output/text/c58cba9c-3c9b-4498-ada2-eb5d42808ae0.txt
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index 0000000000000000000000000000000000000000..eab456fcb667132340b97ed6f962a4dc26b8a6d4
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+tcD -o-3 UUID:1E988E48-9FF4-4355-89CE-410CC1964D6C Redactec cinoio-,acrenal corticej 8370/3 Procedure: L adrenalectomy and splenectomy Q74.O yS xJi|13 Gross description: 11 x 10 x 6cm, tumor 7 x 5.5 x 5cm, 155g Diagnosis: adrenocortical carcinoma, G2 Reference Pathology:. Diagnosis: adrenocortical carcinoma, Kl67 not evaluable Weiss score: 5. Hough score: 1.89 Van Slooten score: 12.3 n
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diff --git a/output/text/c58cd15b-d61c-4bd8-9f98-f23ffc43516d.txt b/output/text/c58cd15b-d61c-4bd8-9f98-f23ffc43516d.txt
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index 0000000000000000000000000000000000000000..e103c0b0ac114d495b1bd011ed53a7400e03a914
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+Page I ot 1 UUID:87B150CC-1C50-42D5-9951-9157A81316D5 Patient: : TCGA-B6-A40C-01A-PR Redacted AP Surgical Pathology: Additional Info Surg Path CLINICAL HISTORY: Spiculated mass with pleomorphic calcifications. If invasive carcinoma, please obtain ER, PR, EGFR, HER2/Neu by inmunohistochemistry; for all 2+ IHC results please do Fish analysis. GROSS EXAMINATION: A. "Left breast, seven cores, with calcifications, 1-2:00 region", in formalin. A 1.5 x 1.0 x 0.3 cm aggregate of multiple core biopsies of pink-tan tissue is entirely submitted in a mesh bag in Al. MICROSCOPIC EXAMINATION:S Microscopic examination is performed. DIAGNOSIS : A. "LEFT BREAST, SEVEN CORES, WITH CALCIFICATIONS, I-2: 0O REGION (STEREOTACTIC NEEDLE CORE BIOPSY) : IcD-o3 INVASIVE ADENOCARCINOMA OF THE BREAST. HISTOLOGIC TYPE: LOBULAR. carcinoma, i nF1fraHrqIobuker NOs NOTTINGHAM COMBINED HISTOLOGIC GRADE: 2 OF 3. 8S30/3 TUBULE FORMATION SCORE: 3. NUCLEAR PLEOMORPHISM SCORE: 2. Sik; bregst,Nos cso9 MITOTIC RATE SCORE: 2. IN-SITU CARCINOMA: PRESENT. 7~Z-1z ro TYPE OF IN-SITU CARCINOMA: LOBULAR (FOCAL DUCTAL FEATURES NOTED). NUCLEAR GRADE OF IN-SITU CARCINOMA: 1. MICROCALCIFICATIONS: PRESENT IN ASSOCIATION WITH INVASIVE CARCINOMA. ESTROGEN/PROGESTERONE RECEPTOR, HER2/NEU, AND EGFR ANALYSIS: PENDING. PARAFFIN BLOCK NUMBER: A1. RESULTS WILL BE ISSUED IN A SEPARATE REPORT FROM THE IMAGE CYTOMETRY LAB. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es).. Electronically signed: : ADDENDUM 1: Please see for results of supplementary tests. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es).. Electronically signed:
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diff --git a/output/text/c59da106-7677-4d4e-9cbd-ad3a3f7c84c9.txt b/output/text/c59da106-7677-4d4e-9cbd-ad3a3f7c84c9.txt
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index 0000000000000000000000000000000000000000..911142415c812f86b73190662ccf2a35a88a195a
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+UUID:1E706FF8-F42C-4FC6-8976-BEB4213BD730 TCGA-AC-A8OR-01A-PR Redacted Referring Physician. DOB: Age; Gender:F Re#: Hosp#: Provider Group Date of Service:n. Date Received: Case #: Date Reported: FINAL SURGICAL PATHOLOGY REPORT Diagnosis: A. - f. LEft breaSt, LEft AXIlLAry TISsUe, Palpable nODe, LEft SENTINEL NODE( ), AND SUPERIOR AND INFERIOR SKIN EDGES, SIMPLE MASTECTOMY, EXCISION OF AXILLARY TISSUE, BIOPSY OF PALPABLE NODE, EXCISION OF SUPERIOR AND INFERIOR ID-O-3 SKIN EDGES, AND SENTINEL NODE BIOPSY: - Invasive mucinous carcinoma, Nottingham grade 1.. 'orcnomo,intiltistis - Tumor size: 1.7 cm in greatest dimension.. mueinswo 84sc/3 - Tumor location: Subareolar. - No in situ component identified. Swte R%ees+NoSC5oq - Margins of resection are negative: S J 4|zJJ 4 - Invasive carcinoma is at least 3.5 cm from all margins.. - No Iymphovascular invasion identified.  One sentinel and one non-sentinel lymph node, negative for tumor (0/2). - Focal atypical ductal hyperplasia identified. - Uninvolved breast parenchyma with fibrocystic changes.. - Benign skin and nipple. - Palpable node biopsy consists of only adipose tissue.. - Separate left axillary tissue consists of benign fibroadipose tissue. - Additional superior and inferior skin edges consists of benign skin and subcutaneous tissue. PATHOLOGIC TUMOR STAGING SYNOPSIS: Type and grade (invasive): Invasive mucinous carcinoma, Nottingham grade 1 Primary tumor: pT1c. Regional Iymph nodes: pNo(i-)(sn). Distant metastasis: N/A. Stage: IA. Lymphovascular invasion: Not identified. Margin status: R0, negative. Case #: Page 1 This report continues... Printed: (FINAL) MR No. Acct No. - Patient Name - Doc# 1 Pathology - Page 1/6
+
+--- Page 2 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT Invasive Breast Cancer Tumor Staging Information. AJCC Cancer Staging Handbook, 7th Ed., and CAP Prolocol (revised June 2012) Previous pathology specimen: Case #. Page 2 Printed: This report continues.. (FINAL) MR NO. Acct No, * tent Name  Pathology - Page 2/6 Page 2 Doc# 1
+
+--- Page 3 ---
+Patient: Case #: SPECIMEN IDENTIFICATION Procedure/specimen type: Sunple mastectomy. Laterality: Left breast. Lymph node sampling: Sentinel node biopsy INVASIVE CARCINOMA TUMOR CHARACTERISTICS Histologic type: Invasive mucinous carcinoma. Tumor site: Subareolar. 1.7 cm. Turnor size: Tunor focality: Unifocal. Histologic grade (Nottingham Score): 1 of 3 (Nottingham score5 of 9) Tubule formation: 20f3. Nuclear pleomorphism: 2 0f 3. Mitotic rate: 1 of 3.  Lymphovascular invasion: Not identified. Macroscopic and microscopic extent of tumor: Benign skin and nipple. DUCTAL CARCINOMA IN SITU (DCIS): Not identified MARGINS Invasive carcinoma At least 3.5 cm away from all margins. LYMPH NODES Total lymph nodes examined 2 (one sentinel and one non-sentinel)  Number of lymph nodes involved 0. Size of largest metastatic deposit N/A. Extranodal extension. N/A. PATHOLOGIC STAGING: Primary Tumor (pT): pT1c. Regional lymph nodes (pN):  pN0(i-)(sn). N/A. Distant metastasis (pM) AJCC Stage: IA, ANCILLARY STUDIES Estrogen.receptor Positive (100%, strong intensily) Progesterone receptor: Positive (99%, strong intensity) HER2: Negative (score 1+), Ki-67: 7% positive cells. Case #. Page 3 This report continues. (FINAL) Printed: MR No. - Pathology '-- Page 3/6 Page 3 Doc#1
+
+--- Page 4 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT Oiyheu vy : Source of Specimen: A. Sentinel lymph node;Left sentinel node #7. B. Breast surgical:Lell axillary tissue C.Breast total mastectomy;Lett D.Lymph nodePalpable node .E. Skin;Superior skin edge F. Skin Inferior skin edge. Clinical History/Operative Dx: Breast cancer.. Intraoperative Diagnosis: A. Left sentinel node Negative for metastasis retation(s) was/were pertormed and rendered at Gross Description: A. Part A designated left sentine! node . (FS). Initially received in a fresh stale for frozen section/touch.  prep evaluation, is a 3.0 x 2.5 x 1.5 cm portion of yellow-lan fat. Examination reveals a single soft to. rubbery pink and tan lymph node measuring 2.5 cm in greatest dimension. A single touch imprint slide is forwarded for microscopic evaluation. The lymph node is entirely subrnilted for routine histology with a sentinel node protocol pertormed, on A1 and A2 B. Part B designated left axillary tissue. Received in formalin is a 4 gram portion of yellow-tan fibrofatty  sof tissue measuring 3.8 x 2.2 x 1.5 cm. Examination reveals softened yellow-tan fat, without prominent Iymph node content. The fatly tissue is entirely submitted for microscopic evaluation for possible minute. lymph node content, in B1-B3 C. Received in the fresh state tor tumor harvest for. tumor bank. The specimen is Page 4 Case #: This report continues.. (FINAL) Printed: MR No. * cct No Pathology - Page 4/6 Job C#1
+
+--- Page 5 ---
+Patient: Case # FINAL SURGICAL PATHOLOGY REPORT labeled *lefl breast mastectomy * Sutures present for orientation purposes: Suture - medial. Laterality:Left. Specinen: Simple mastectomy. Size of mastectomy: (M-L x S-1 x A-P): 21.4 x 12.4 x 5.5 cm (including lateral extension of fat). Axillary tail: 8.0 x 6.8 x 1.8 cm extension of lateral fat. Skin: 17.7 x 6.4 cm.Nipple/areola: Present.. Specimen weight: 489 grams. Ink code: Blue - superior-anterior, orange - inferior-anterior, black - deep Slabs:Total #12, M=1, L=12. Nipple in slabs #6-7. Time of resection: Not documented Time placed into formalin Time out of formalin: Lesion 1: Biopsy site: Spring and hook-shaped radiologic marker appreciated along anterior-lateral periphery of lesion (slab 7). Size: 1.7 x 1.5 x 1.5 cm, well-circumscribed, pink-tan. gelatinous appearing, mucinous tunor mass. Location: Subareolar.Involves slabs #6-7 Distance to nearest margin(s): 3.5 cm from superior superficial and inferior superficial, 1.0 cm trom skin. greater than 4.5 cm from most medial and lateral edges of breast. Non-lesional breast: Serial sections of the breast demonstrate predominantly tatty. glistening. lobular adipose tissue without additional discrete nodularity/lesion. Exanination of the most lateral extension of  breast reveals a single lymph node, measuring 0.8 x 0.7 x 0.4 cm. Several embedded staples are present. Cassette summary: C1) nipple, C2) medial and lateral extension of skin. C3) slab 5, medially adjacent io lesion, C4) slab 6.tumor, C5) slab 6, lesion and skin relationship.. C6) slab 7, lesion, C7) slab 7, tumor, site marked by radiologic marker, C8) slab 7, tissue medially inferior to lesion (dense changes), C9) slabs 6-7, deep margin. C10) slab 7, superior superficial surgical margin adjacent to lesion, C11) siab 7, inferior superficial surgical margin adjacent to lesion, C12) slab 8, adjacent to lesion, C13) slab 10, upper outer quadrant C14) slab 10. lower outer quadrant, C15) slab 3, lower inner quadrant. C16) slab 3, upper inner guadrant, C17) single lymph node D. Part D designated paipable node. Received in formalin is a fatty tissue fragment measuring 1.0 x 0.8 x Pege 5 Case # Printed: This report continues... (FINAL)} MR No. Pathology - Page 5/6 j Doc# 1
+
+--- Page 6 ---
+Patient: Case i FINAL SURGICAL PATHOLOGY REPORT 0.3 cm. The tissue is serially sectioned and entirely submitted for microscopic evaluation in D1. E. Part E is superior skin edge, clip medial. Received in lormalin is an elliptical strip of erythematous. pink. and tan skin with subcutaneous 1at measuring 12.0 x 0.8 cm with a 1.0 cm deep surgical margin.A clip is near one apex designating medial. The superior edge of the skin and surgical margin is now marked blue. Sectioning reveals glistening, yellow-tan subcutaneous fat without grossly unusual areas of chang. suggestive of neoplasia. Representative sections are submitted for inicroscopic evaluation in E1. F. Pait F is inferior skin edge, clip medial. Received in formalin is an elliptical strip of erythematous, pink. and tan skin with subcutaneous fat measuring 12 5 x 1.0 cm with a 1.8 cm deep surgical margin.A clip is near one apex designating medial. The inferior edge of the skin including superticial surgical margin are now marked green. The specimen is serially sectioned demonstrating glistening, yellow-tan, lobular. subcutaneous fat without discrele nodularity or grossly unusual areas of change suggestive of neoplasia.n. Representative sections are submitted for microscopic evaluation in F1 (two pieces) Microscopic Description:. A. - F. Microscopic sections have been examined. The microscopic findings-are rellected in the diagnosis. rendered. The sentinel node (par A) was evaluated by H&E ievels and OSCAR-cytokeratin immunostains. Controls.are appropriate. Case Page 8 Printed: END OF REPORT(FINAL) MR No. * . Pathology - Page 6/6 c 3 Doc# 1
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index 0000000000000000000000000000000000000000..a4bf696f31a6f8c3a5f77a5b1d03f22634a8e72e
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+UUID:8A26F1CA-2DD1-46FD-B2A7-FEFDF3811455 TCGA-KM-A7Q-01C-PR Redacted MEDICAL RECORD Revised Surgical Pathology Report Revised Surgical Pathology Report PATIeNT: MRN: ACCOUNT#: RECEIVED DATE: DOb: PROceDUre DATE: AGE: SEX: M SigN-Out DATE: ATTENDING: LOCATION: REQUESTING: CONTACT NO: ROOM: COPIES TO: REVISED REPORT REAsON FOR REvIsiON: A computer software error caused corruption in the original final report. This incomplete, corrupted report was signed out so that a clean revised report could be created. This revised report therefore represents the true original final report. DiAGnosis: Kidney, right (radical nephrectomy): Renal cell carcinoma, chromophobe type, Fuhrman nuclear grade 2, vascular and ureteral margins are free of tumor. Tumor does not Invoive the capsule, see Note. NOTE: ID-o3 Kidney Nephrectomy Summary Table Macroscopic lrcinoma,ninsl cll chrompsohe 831773 Specimen Type: Radical nephrectomy. Laterality: Right B4Ldney NoS Tumor Size: 4.0 cm C649 Focality: unifocal UJ 9/Q41 3 Macro Extent of Tumor: Tumor limited to kidney Microscopic Histologic Type: Chromophobe Histologic Grade: G2 Extent of Invasion Primary Tumor(pT): PT1a Regional Lymph Nodes(pN): pNx Distant Metastisis(pM): pNx Margins: Uninvolved by invasive carclnoma Patient Identification Page 1 of 3
+
+--- Page 2 ---
+MEDICAL RECORD Revised Surgical Pathology Report. Name: MRN: Date of Report: CLINICAL INFORMATION: Brief Clinical History: right renal mass Specimen Taken For Protocol: Requestor Name Requestor Phone/Pager: Admitting Protocol Number: PRocEDuRE: Pre-Operative Diagnosis: right renal mass Post-Operative Diagnosis: right renal mass Operative FIndings: right renal mass SPeCImENS SUbMITTED: 1. KIDNEY, RIGHT GROSS DESCRIPTION: Received from the OR labeled with the patlent's name, medical record and *right kidney* is a radical nephrectomy specimen measuring over all 17.0 x 10.0 x 6.0 cm and weighing 550 gm, containing the Gerota's fascia (kidney is measuring 7.0 x 6.0 x 3.5 cm). The ureter, renal artery, renal'vein are identified (ureter measuring 10.0 cm in length by 0.5 cm in diameter, renal artery measuring 1.5 cm in length by 0.4 cm in diameter, renal vein measuring 1.5 cm in length by 0.8 cm in dlameter).  The specimen is inked in black and blvalved to reveal a nodule measuring 3.0 x 3.5 x 4.0 cm with variegated gray/brown cut surface, confined in the lower pole of the kidney. The remaining of the kidney appears normal (cortical thickness is 1.2 cm, medulla thickness is 1.7 cm). Approximately 1.5 x 1.5 cm ofthe tumor tissue and two slices of normal kidney parenchyma (each measuring 1.2 x 4.0 x 4.0 cm) were procured for by and on The rernaining specimen is sent to Surgical Pathology. In Surgical Pathology is received in filled container and is consistent with above description. It is sectioned for further examination. Adrenal gland is not identifled. Lymph nodes are grossly not identified. Representative section in submitted in white cassette labeled and further described as follows:. A.  Resection margin (ureter, renal artery, renal vein). B-D. Tumor mass E-F. Perirenal fat, lymph nodes?. G. Normal appearing kidney H-P. Tumor mass Patient Identification 2 0f 3
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+MEDICAL RECORD Revicad Curni -. athology Report Date of Report: Patient Identification Page 3 of 3.
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+UUID:BC3170CA-A046-4D78-9CC6-36C5870A9C4C TCGA-3A-A9IS-01A-PR Redacted Pathology Report Final Diagnosis DISTAL PANCREAS AND SPLEEN, PANCREATECTOMY AND SPLENECTOMY -Pancreatic well ditferentiated neuroendocrine carcinoma - See key pathologic findings.. - Thirty-two benign tymph nodes (0/32) The attending pathologist, peraonally reviewed all slides and / or materials and rendered the final diagnosis. Electronically Sigred Out by Comment The mitotic count is 1 per 10 high power fields: this count corresponds to a low-grade neurpendocrine carcinoma (G1). ID-03 A Ki67 immunostain is pending. A report will follow. 8.24e/3 Key Pathological Findings Sute.: Ynesselisoly D36 1 Tumor type: neuroendocrine carcinoma ) 4j//i1J4 Tumor location:pancreas,distal Histologic grade: low-grade. Tumor size:8 x 4.7 x 3.0 cm Vascular invasion: absent Perineural invasion: absent Extrapancreatic extension (for pancreatic tumors only): absent Surgical margins:uninvolved Extent of invasion: The tumor is confined within rts capsule Non-neoplastic pancreas:Focal chronic pancreatitis Lymph nodes (total): 0/32 TNM stage: pT2, pNO Specimen(s) Received A DISTAL PANCREAS AND SPLEEN FS Clinical History Pancreatic neuroendocrine tumor.
+
+--- Page 2 ---
+Preoperative Diagnosis  Pancreatic neuroendocrine tumor. Intraoperative Consultation FSA DISTAL PANCREAS AND SPLEEN: Distal pancreas margin: Negative for tumor. Comment: This frozen section diagnosis/result is communicated to and acknowledged by Dr. AD,have performed the intraoperative consuitation and issued the above diagnosis. Gross Descriptiond  Specimen A is received fresh for frozen section consuitaton, labeled *distal pancreas and spleen" and consists of a 571.3 gram distal pancreas with attached spleen. The pancreas is 14.5 x 5.0 x 4.0 cm. The spleen is 17.0 x 12.0 x 4.7 cm. Within the pancreas is an 8.0 x 4.7 x 3.0 cm.. partially encapsulated, soft tan and orange, lobulated mass. The mass extends the full length of the pancreas and is 0.7 cm from the pancreatic margin. The mass has a surrounding, thin membranous lining, which is inked blue. There is a small amount of normal pancreatic tissue surrounding the mass The remaining pancreas is yellow, lobulated, admixed with thick, white fibrous stroma. The spleen is homogeneous, dark red, and slightly nodular. No mass or other lesions are identified. The pancreatic margin is sectioned tangentially, frazen and entirely submitted in FSA1. Additional representative sectons are submitted as follows: A2: Mass perpendicular to margin.. A3-A4: Mass with adjacent normal pancreas. A5-A6: Mass with surrounding thin membrane.. A7-A8: Mass. A9: Mass with duct A10: Normal pancreas. A11: Normal spleen. A12. 7 possible lymph nodes.. A13. 7 possible lymph nodes. A14: 7 possible lymph nodes, 2 differentially inked and bisected.. A15. 5 possible lymph nodes.. A16: 4 possible lymph nodes, 2 differentially inked and sectioned.. A17-A18: 1 possible lymph node,sectioned A portion of tissue is submitted to Tissue Procurement Laboratory 1/3/14 Primary Tumor Site HIPAA Discrepancy Prior Malignancy Histo Dual/Synchic QUALIFISD DISQUALIFIEO
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diff --git a/output/text/c635623c-8126-435b-8c3e-ab64ce24bb67.txt b/output/text/c635623c-8126-435b-8c3e-ab64ce24bb67.txt
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index 0000000000000000000000000000000000000000..05f2982db1c4fa009627419715f8cb98f26e5425
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+--- Page 1 ---
+TCGA-A3-A8OW-01A-PR Redacted Referring Phvsician DOB: Age: Gender:M Ref#: Hosp#: Patient I ocation: Date of Service: Date Received: Date Reported: FINAL SURGICAL PATHOLOGY REPORT Diagnosis: KIDNEY, LEFT, RADICAL NEPHRECTOMY: - CLEAR CELL RENAL CELL CARCINOMA, WITH SOLID AND CYSTIC AREAS. - Tumor is 3.3 cm in maximum dimension.. - Fuhrman nuclear grade: 2. - Tumor extends into perinephric adipose tissue, but not beyond Gerota's fascia. - MARGIN STATUS: NEGATIVE - ADRENAL GLAND UNINVOLVED BY TUMOR. PATHOLOGIC STAGING SUMMARY: Type and grade: Clear cell renal cell carcinoma, Fuhrman nuclear grade 2. Primary tumor: pT3a (tumor extends into perinephric adlpose tissue, but not. beyond Gerota's fascia). Icd -0.3 Regional lymph nodes: pNX.. Distant metastasis: pMX. Pathologic stage: III. Sit O%idny NoS Cb4.9 Lymphovascular invasion: Not identified.. Margin status: R0. QSk1n114 Case #: Page 1 Printed: This report continues... (FINAL).
+
+--- Page 2 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT Tumor Staging Information (data derived from current specimen, staging in accordance with or modified from AJCC Cancer Staging Handbook, 7th Ed, and CAP protocol, February 2011) Specimen type: Kidney. Procedure: Radical nephrectomy. Specimen laterality: Left. Tumor site: Middle portion of kidney. Tumor size: Greatest dimenslon:3.3 cm Additional dimensions: 3.2 x 2.8 cm. Tumor focality: Unifocal. Macroscopic extent of tumor: Tumor limited to kidney. Histologic type: Clear cell renal cell carcinoma. Sarcomatoid features: Not identified. Tumor necrosis: Not identified. Histologic grade: Fuhrman nuclear grade 2. Microscopic tumor extension: Tumor extends into perinephric adipose tissue, but not beyond Gerota's fascia. Margins: RO. Lymphovascular invasion: Not identified. Pathologic tumor staging: Primary tumor: pT3a (tumor invades perirenal fat, but not beyond Gerota's fascia). Regional lymph nodes: pNX. Distant metastasis:. pMX. Pathologic stage: IIi. Margin status: RO. Signea Source of Specimen: Left Kidney nephrectomy Clinical History/Operative Dx: Case #: Page 2 Printed This report continues... (FINAL)
+
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+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT Renal mass Gross Description: The specimen is labeled left kidney and is received in formalin. It consists of a nephrectomy specimen which together with perinephric fat weighs 446 grams. It measures 17.5 cm from superior to inferior, 9 cm from medial to lateral, and 4.5 cm from anterior to posterior. Along the medial-superior edge of the perinephric fat there is a intact appearing 6.5 x 3.5 x 1 cm portion of adrenal gland. Along the anterior surface of the kidney there is a thin delicate membranous tissue consistent with Gerota's fascia approximately measuring 10 x 5 cm. The central-lateral surface of the nephrectomy specimen is torn and disrupted exposing the cortical surface of the kidney which is bulging. Serial sections of the adrenal gland reveal no gross evidence of tumor involvement. At the hilum of the kidney the renal artery and renal vein are identified. The vessels are opened and there is no gross evidence of intraluminal tumor. Extending from the hilum of the kidney is a small caliber portion of ureter which is 6.5 cm in length and 0.3 cm in diameter. The ureter is opened to the renal pelvis to reveal the urothelium is tan-white and smooth and unremarkable. Sectioning through the central-lateral surface of the kidney reveals a well circumscribed golden yellow and thinly capsulated appearing neoplasm which overall measures 3.3 x 3.2 x 2.8 cm. This neoplasm abuts the cortical surface of the kidney but grossly does not appear to extend through the renal capsule into the small amount of adherent perirenal adlpose tissue. The neoplasm is 3.5 cm from the hilum and hilar vasculature. There is some cautery and cavitatlon of the renal parenchyma just along the superior edge of the tumor suggestive of surgical manipulation. There is some hemorrhage extending into the hilar fat. The kidney away from the neoplasm has a normal reddish brown appearance and the cortical medullary junction appears distinct. The cortical thickness is 0.7 cm. Close sectioning of the remainder of the kidney reveals no additlonal masses. The perinephric adipose tissue is dissected but no Iymph nodes are identified grossly. Also in the specimen container is an additional 7.5 cm aggregate of lobulated fatty tissue which is serlally sectioned and palpably unremarkable. Representative sections of the tumor are obtained for research purposes. Followlng fixation the sections are submitted as summarized below: Section summary: A1) surgical margin, renal artery, renal vein and ureter, A2) adrenal gland, A3) additional sections of ureter and ureteral pelvlc Junction, A4) Gerota's fascia, A5-A7) sections of central-lateral tumor and cortical surface of kidney, A7-A8) sections of tumor and immediately adjacent renal tissue. Additional section of tumor adjacent to the renal sinus was submitted in A10, and an additional section of renal artery and renal vein are submitted in cassette A11. Microscopic Description: Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered. Case #: Printed:
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diff --git a/output/text/c64b36e8-9d0d-428c-b44c-3396b998f997.txt b/output/text/c64b36e8-9d0d-428c-b44c-3396b998f997.txt
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index 0000000000000000000000000000000000000000..12618b86ca57563258abad67aa1eff90746f500f
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+1cp-0-3 c50.9 1a7/u Iin: brest,nts SURGICAL PATHOLOGY REPORT Name: Lab No.: Sex: F Date Collected: Age: Date Received: Doctor: M.R. No.: Room No: Hosp.No: CLINICAL HISTORY: PREOPERATIVE DIAGNOSIS: Right Breast Cancer POSTOPERATIVE DIAGNOSIS: OPERATION: Lumpectomy Right Breast, Right Sentinel Lymph Node Biopsy SPECIMEN:  A) Right Breast Mass - 1 Short Anterior - 2 Short Superior - 1 Long Medial, B) SentineI Node #1 F.S., C) Sentinel Node #2 F.S., D) Axillary Contents E) Gross Margin Additional Inferior Margin Right Breast Mass suture New Inferior Margin FROZEN SECTION DIAGNOSIS: A) GROSS MARGINS: VERY CLOSE (LESS THAN 1 MM), TO INFERIOR MARGIN. B) SENT LYMPH NODE #1 - POSITIVE FOR METASTATIC CARCINOMA. C) SENT LYMPH NODE #2 -- POSITIVE FOR METASTATIC CARCINOMA. 8793-461A-B17E-E6584CE24238
+
+--- Page 2 ---
+PAGE 2 Name: Lab No.: Sex: F Date Collected: Age: Date Received: Doctor: M.R. No.: Room No: Hosp.No: FINAL DIAGNOSIS:  A) RIGHT BREAST TISSUE - POORLY DIFFERENTIATED INFILTRATING DUCTAL CARCINOMA SCARFF-BLOOM-RICHARDSON GRADE III/III. THE TUMOR MEASURES 3.5 CM. IN MAXIMUM DIMENSION AND FOCALLY CLOSE TO ANTERIOR AND POSTERIOR SURGICAL MARGINS, (LESS THAN 1 MM.), SLIDES #5 AND #6 THE REMAINING SURGICAL MARGINS ARE FREE OF THE LESION. LYMPHOVASCULAR INVASION IS IDENTIFIED MICROCALCIFICATIONS ARE IDENTIFIED. B) SENTINEL LYMPH NODE - ONE (1) POSITIVE LYMPH NODE, (1/1) C) SENTINEL LYMPH NODE - ONE (1) POSITIVE LYMPH NODE, (1/1). D) AXILLARY CONTENTS - 2 OF 13 LYMPH NODES ARE POSITIVE FOR MALIGNANCY, (2/13). E) ADDITIONAL RIGHT BREAST TISSUE - NEGATIVE FOR MALIGNANCY. PTNM CLASSIFICATION: PIIa, T2, N2, MX PATHOLOGIST
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diff --git a/output/text/c64be79b-a70a-4c45-bddf-96e113c91802.txt b/output/text/c64be79b-a70a-4c45-bddf-96e113c91802.txt
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index 0000000000000000000000000000000000000000..762b64ce217d62fb9b8a2a290f0e485abfadf6d9
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+Pathology Form Specimen Information Date: Date Frozen Paraffin Block Blood/Serum/Plasma Slide Diseased Normal Diseased Normal Diseased Normal Diseased Normal 4 2. 2. 2 Time to LN2 Time to Formalin Time to LN2 10 min min min. Primary Tumor Organ Size Extension of Tumor Distance to NAT Co/on 3x x3 cm E LAAOR cm Lymph Nodes. Location # Examined # Metastasized Distant Metastasis Organ  Detailed Location Size Pathological Staging pT 3 No M o Stage:  Notes: Colon nole (neg7ive ) 4
+
+--- Page 2 ---
+Microscopic Description eweseHistologicalPatternww.t Cell Distribution + Structural Pattern + Diffuse  Streaming  Mosaic  Storiform Necrosis x Fibrosis Lymphocytic Infiltration. Palisading Vascular Invasion  Cystic Degeneration Clusterized Bleeding  Alveolar Formation  Myxoid Change Indian File  Psammoma/Calcification SenzaawoaeaCellular Differentiationnarawt  Squamous + Adenomatous + Sarcomatous + Lymphomatous  Squamoid Cell Glandular cell  Round Cell  Large Cell  Spindle Cell Cell Stratification Fibroblast Small Cell Keratin Secretion  Osteoblast RS Cell/RS Like Desmosome Intracyt. Vacuole Lipoblast Inflam. Cell  Peart Gland formation x Myoblast Plasma Cell Cellular Differentiation: Well IZ Moderate Poor Nuclear Atypia: 0 II III Aniso Nucleosis x Hyperchromatism  Nucleolar Prominent  Multinucleated Giant Cell.  Mitotic Activity Nuclear Grade: Marker Result Value Date ER Negative  Positive PR  Negative  Positive Her-2/neu  Negative  Positive B-Cell Marker  Negative  Positive T-Cell Marker.  Negative  Positive Other:  Negative   Positive Other:  Negative   Positive Final Pathology Report Adeno cPRci noma Histological Diagnosis:. Grade: Comments: 5
+
+--- Page 3 ---
+COnsOlIdaTeD DIagnOsTIC pathOLOgy fORm* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION + STRUCTURAL PATTERN Diffuse + Y] Streaming Mosaic  Storiform Necrosis X  Fibrosis Lymphocytic Infiltration  Palisading  Vascular Invasion  Cystic Degeneration Clusterized Bleeding Alveolar Formation Myxoid Change Indian File 1 Psammoma/Calcification 2. Cellular features: Squamous +1  Adenomatous + Sarcomatous + Lymphomatous +  Squamoid Cell Glandular cell Round Cell Large Cell Spindle Cell Cell Stratification.  Fibroblast Small Cell Keratin Secretion Osteoblast _RS Cell/RS Like  Desmosome Intracyt. Vacuole 4  Lipoblast  Inflam. Cell Pear!  Gland formation Myoblast  Plasma Cell Otherwise Specified: 955 Dr 58% D3 707 D460% 2.Cellular Differentiation: Well Moderately Poor X 3. Nuclear Atypia: Nuclear Appearance Aniso Nucleosis A Hyperchromatisim Nucleolar Prominent Multinucleated Giant Cell  Mitotic Activity Nuclear Grade Histological Diagnosis: Doseefed M: clkexrir WdBladeeihs. Comments:
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diff --git a/output/text/c669b6c5-e0c1-4b4f-a260-8a599a3fe31d.txt b/output/text/c669b6c5-e0c1-4b4f-a260-8a599a3fe31d.txt
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index 0000000000000000000000000000000000000000..82f2144e6f81fe863cbb8b08448fb1d51271fcc4
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+--- Page 1 ---
+UUID: DA03F6F5-2579-45B7-954B-8C0F8EFD0F75 Redacted TCGA-MR-A8JO-01A-PR Normal Blood ID: ICD-0-3 SPECIMEN(S): Careinome, hepstocsslulor 817113 fibreameslar A: Left lower liver and tumor Sut:oZsuer CQQ.O B: Lesser curvature lymph nodes yJ 1/27/14 C: Gallbladder FINAL DIAGNOSIS: A. Left lower liver and tumor, Left hepatectomy: - Hepatocellular carcinoma, fibrolamellar variant, 13.5 cm - Margins: Negative for carcinoma - Non-neoplastic liver parenchyma with mild portal inflammation - See cancer checklist and comment B. Lesser curvature lymph nodes, excision: - One lymph node, negative for carcinoma (0/1) C. Gallbladder, cholecystectomy: - Chronic cholecystitis COMMENT: The immunohistochemical stains performed with adequate controls shows that tumor cells are positive for CK7 and CD68, supporting the above diagnosis. Cancer checklist: Specimen: Liver Procedure: Partial hepatectomy Tumor Size: 13.5 x 12.5 x 8.0 cm
+
+--- Page 2 ---
+Tumor Focality: Solitary. Histologic Type: Fibrolamellar hepatocellular carcinoma Histologic Grade: Glll, Poorly differentiated. Tumor Extension: Tumor confined to liver. Margins: Uninvolved by invasive carcinoma. Distance of invasive carcinoma from closest parenchyma margin: 2 cm Lymph-Vascular Invasion: Not identified Macroscopic Venous (Large Vessel) Invasion (V): Not identified Microscopic (Small Vessel) Invasion (L): Not identified Perineural Invasion: Not identified. Regional Lymph Nodes (pN): Number of Lymph Nodes Examined: 1 Number of Lymph Nodes Involved: 0 Distant Metastasis (pM): Not applicable. Additional Pathologic Findings: Mild portal inflammation Pathologic Staging (pTNM): pT1 NO Mx CLINICAL HISTORY:S The patient is a  -year-old male with left renal mass. Operative Procedure: Partial hepatectomy.. GROSS: Three formalin-filled containers are received, each labeled with the patient's name and hospital identification number. The first container is received fresh and subsequently saved A.
+
+--- Page 3 ---
+in formalin in the container labeled "A-left lower liver tumor short-stitch superior, long-stitch anterior." The specimen consists of a 957 gm partial hepatectomy specimen measuring 15.5 cm from medial to Iateral, 15 cm from anterior to posterior, and 8.0 cm from superior to inferior. The hepatic capsule is yellow-brown, smooth and mostly occupied by a multinodular large mass. The specimen is oriented with a short-stitch at superior and long stitch at anterior. On sectioning, reveals a 13.5 x 12.5 x 8.0 cm, yellow-red variegated large mass. Focal small cystic areas ranging from 0.1 to 0.5 cm in greatest dimension are noted. The solid area is mostly yellow and focally red hemorrhages. Multifocal dark red and friable possible thrombi are noted ranging from 0.5 to 1.0 cm in greatest dimension. The large mass is abutting to the hepatic capsule surface; however, it is complete and intact. This mass is moderately well defined and 2.2 cm to the closest parenchymal margin and 2.7 cm to the hepatic vein and artery margins. This mass is occupying 90 percent of total specimen and the remaining hepatic parenchyma is yellow-brown with no cirrhotic changes. The specimen is photographed and representative sections are submitted. Summary of Sections: A1 - vascular margins.. A2-A3 - mass with closest parenchymal margin. A4-A5 - mass with thrombi.. A6 - mass with yellow necrosis.. A7-A8 - mass with surrounding hepatic parenchyma. A9 - mass.
+
+--- Page 4 ---
+A10 - uninvolved hepatic parenchyma. B. The second container is received fresh for intraoperative consultation and labeled "B-lesser curvature lymph node." The specimen consists of a 1.2 x 0.8 x 0.6 cm lymph node. The specimen is entirely submitted for frozen sections and remnants in B1FS.  The next container is received in formalin and labeled "C-galibladder." The specimen consists of a 6.3 x 3.5 x 2.5 cm intact gallbladder. The serosa is red-purple-green and smooth. The adventitia is red-tan, which is inked black. The gallbladder is opened to reveal approximately 20 mL dark green viscous bile in the lumen. The mucosa is dark green and velvety. The cystic duct is patent and unremarkable. The gallbladder wall is 0.2 to 0.3 cm in thickness. No calculi are identified. Representative sections to include cystic duct, fundus and neck are submitted in C1. INTRAOPERATIVE CONSULTATION: FROZEN SECTION DIAGNOSIS: AFS1: Lesser curvature lymph node. "No evidence of carcinoma." MICROSCOPIC:E Permanent sections confirm the frozen section diagnosis. iterla, PA
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index 0000000000000000000000000000000000000000..27c381726248a20692768d3a780a92b47ba33b47
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+UUID:D03F4355-72A4-4CDF-B7BE-DD8016D69A90 TCGA-P6-A50F-01A-PR Redacted Go to... Report for? TEST: Surgical Pathology Collected Date & Time: Result Name Results Units Reference Range Surgical Pathologyo SURGICAL P xeD0-3 SURGICAL PATHOLOGY REPORT Adreuo!. estrca! See Addendum orc in ome 83703 Patient Name: Accession # Med. Rec. #: Billing Type: L 74.D Location: A/24/3 Dob: (Age: Service: Gender: F Billing Taken Phyaician(s) : Specimen(s) Received A. Falcifoxm ligament B: Gallbladder C: Tissue next to right common bile duct D:  Right adrenal cortical carcinoma intracaval thrombus E: Gerota's tascia F: Liver Pathologic Diagnosis Falciform ligament, biopsy (A) : Benign fibroadipose cissue. Galibladder, excision (B): Chronic cholecystitis. Cholelithiasis. Tisaue next to right common bile duct, biopsy (C):. Benign fibroadipose tissue. Adrenal gland, right and intracaval thrombus, excision (D): Adrenocortical carcinoma, see note. Note: The right adrenal gland weighs 277 grams and measures 1o.5 cm in greatest dimension. The neoplasm demonstrates areas of necrosis with focal venous invasion present. There is The lesion does not appear to invade the capsule of the adrenal gland. The capsulax margins of oxcision appear free of malignancy.  There is thrombus present consisting of admixed. tumor and hemorrhage..  This thrombus correaponds to the clinically described:intracaval chrombus. The neoplastic cells are immunoreactive ior inhibin, calretinin, synaptophysin, and melan A; and non-immunoreactive for cD99. The immunohistochemical findings support the above diagnosis.. Gerota's faacia, biopsy (E): Benign fibroadipose tissue. Liver, biopsy (F): Hepatic parenchyma with mild macrovesicular steatosis
+
+--- Page 2 ---
+3/15 r agc z u1 J and subcapsular homorrhage.. SURGICAL PATHOLOGY CANCER CASE SUMMARY CHECKLIST: Specimen: Adrenal gland, resection; received in formalin. Procedure: Adrenalectomy, total.. Specimen Integrity: Intact. Specimen Size: Greatest dimension 10.5 x 9.5 x 5.0 cm. Specimen Laterality:. Right. Tumor siae: 10.5 cm. Tumor Gland Neight: 377 g. Histologic Type: Adrenocortical caroinoma. Margins: Capaular margins are negative, neoplasm involves. inferior vena cava. Treatment Effect: Not identified. Lymph-Vascular Invasion: Present, large and small vessel. Perineural Invasion: Not identified. PATHOLOGIC STAGE: Primary tumor: pT4.  Region lymph nodes: pNx. Distal metastasis: Not applicable.. Nore: Information on pathology stage and the operative procedure is transmitted to this Institution' s Cancer Registry as required for accreditation by the Commission on Cancer. Pathology stage is based solely upon the current tiasue specimen being evaluated and does not incorporate other relevant data. Pathology stage is only a component to be considered in determining the clinical stage and should not be confused with nor substituted for it. The exact operative procedure is available in the surgeon' s operativa xaport. Fximary Pathologist: Addendum The modified Neiss score of the neoplasm is 4. Moditied weiss acores of greater than 3 auggeat malignancy (AJsp 3002; 26:l612). Eleatronically Signad Out by. Clinical History Right adrenal cortical carcinoma.. Intraoperative Consultation A: Falciform ligament: Benign (microscopic). c: Tissue naxt to right common bile duct:  Benign fibrovascular and adipose tisaue (microacopic). Gross Description A: Received fresh for frozen section labeled rfalciform. ligament" is a 6.5 x 5.5 x 1.5 cm gliatening yellow, lobulated adipose tiseue partly surfaced by glistening tan-blue, poesible. peritoneum. Soctioning reveals a 1.5 x 1.0 x 0.3 cm gray-tan fibrous area. No other suspicious areas are grossly identified. No diacrete maases are grossly idantified. The remainder of the. specimen consists of unremarkable yellow-tan fibrofatty tissue. Ropresentative sections are submitted as labeled: "yg-A1* auspicious fibrous area in total, nys-A2* possible peritoneum, "Fs-A3n random sections (three cassetces). B Received in formalin Iabaled sgallbladder* is an intact 8.5 x 3.0 x 3.0 cm gallbladder with a 1 cm cyatic duct. Within the cystic duct and gallbladder lumen is a 6.0 x 4.5 x 1.0 cm
+
+--- Page 3 ---
+4/15 ruge s or  aggregate of multiple yellow-green, multifaceted stones ranging adventitia ie shaggy, tan-yellow. The walls have uniform.  The thickness and average o.l cm. The mucosa ia heterogenoua, green-yellow and varies from granular to flattened. The lumen contains a moderate amount of green-yellow viacous bile. Representative sections are submitted to include ths cystic duct margin inked blue (one casaette).. C:  Received fresh for frozen section labeied "tissue next to right common bile ductn is a 2.0 x 1.0 x 0.3 om aggregate of a few irregular fragmenta of yellow-tan fibrotatty tissues. The specimen is submitted in toto for frozen section in "ys-c1n. D:  Received in formalin labeled sright adrenal cortical carcinoma intracaval 'thrombus" is a disrupted 277 g, 10.5 x 9.5 x S.0 cm aoft mass and a 5.0 x 5.0 x 1.0 cm aggregate of yellow-tan fibrotatty tisaue. The mass is focally disrupted and previously incised.  The external surface is predominantly smooth, The mass is inked black and serially sectioned revealing a heterogenous tan-red, slightly gritty cut surface. On the surface of the mass ia a 5.5 x 2.0 x 0.3 cm remnant of adrenal gland with a heterogenous golden-yellow cut surface. adronal remnant is a o.4 cm diameter, well-circumscribed rubbery Within the nodule with a homogenous tan-pink aut surface.. through the separate aggregate of fibrofatty tissue reveals a Sectioning homogenous yeliow, lobulated cut surface, and a moderate amount of admixed blood clot. No discrete masses are grossly identified. Representative sectiona are submitted as labeled: "p1n-sp6" masa periphery and adrenal gland xemnant, "p7" remainder of adrenal gland remnant and nodule in toto, "pgn separate aggregate of fibrofatty tisaue, "pg*-"pio" blood clota (ten cassettes). The apecimen is reviewed by E: Received in formalin labeled "Gerota's fascia" is an I1.0 x 10.5 x 2.5 om aggragate of multiple fragments of yollow, lobulated adipose tissue, admixed with a minimal amount of blood clot. Sectioning reveals a homogenous yellow, lobulated cut surface. No discrete masses or suspioious areas are grossly identified. Representative sections are submitted (two Casgettea). *: Received in formalin labeled nliver" ig a 26 g, 7.0 x 6.5 x 1.5 cm aggregate of several fragments of diarupted and hemorrhagid hepatic tissue and yeilow, lobulated adipose tissue. The specimen is serially sectioned. The hepatic tisaue has a hecerogenous, tan-green cut aurface. The adipose tisaue has a homogenous yellow. lobulated cut surface. No discrete masses are grossly identified. Representative sections are submitted as labeled: ayin-*pan hepatic ciasue, "y3" adipose tissue (three Cassettes) . Microscopic Desoription. Microscopic examination has been performed on all slides. The pathologic diagnosis encompasses the essential microscopic Findings of this case.. Interpretation performed at. ISCIUAL
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diff --git a/output/text/c68d5dde-6199-40af-a55e-0aeec5321dda.txt b/output/text/c68d5dde-6199-40af-a55e-0aeec5321dda.txt
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index 0000000000000000000000000000000000000000..f82ff2e2a23ad76b9c18485ea9fdd0392f334862
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+--- Page 1 ---
+UUID:3A87B5EE-D1AE-4D28-8F7A-3898AD4E0796 TCGA-BH-AB28-01A-PR Redacted Anonymous number: Accession Date: Collection Date: FINAL DIAGNOSIS: Part 1: Lymph nOde, Left AxIllA Sentinel nOde #1, BiOpsy - mETASTATIC ADENOCARCINOMA inVOLVING ONE LymPH NODE (1/1), UP TO 7 MM (1A), CONFIRMED BY AE1/AE3 CYTOKERATINE IMMUNOSTAINING ( (see comment). Part 2: lymph node, Left axillA, sentinel #2, Biopsy - METASTATIC ADENOCARCINOMA INVOLVING ONE LYMPH NODE (1/1), UP TO 7 MM (2B), CONFIRMED BY AE1/AE3 CYTOKERATINE IMMUNOSTAINING ( (see comment). Part 3: Lymph nOde, LEft AxIlLA, SEnTinel #3, biOpSy - METASTATIC ADENOCARCINOMA INVOLVING ONE LYMPH NODE (1/1), UP TO 4 MM (3A), CONFIRMED BY AE1/AE3 CYTOKERATINE IMMUNOSTAINING ( (see comment). PARt 4: Lymph nODE, LEft AXILLA, SENTineL #4, BIOPSy -- ONE LYMPH NODE, FREE OF TUmOR (0/1), (see comment). Part 5: breast, Left, total mastectomy - A. INFIULTRATING LOBULAR CARCINOMA (5C, 5D, 5E, 5F, 5H, 5I, 5J, 5K, 5L, 5M, 5N, 50, 5P, 5Q, 5R, 5S, 5T, 5U, 5V, and 5AA) B. The TumOR SIZe IS: 8.0 X 6.5 X 4.2 CM. C. NOTTINGHAM SCORE IS: 6/9 (TUBULES 3, NUCLEI 2, MITOSIS 1). D. LYMPHOVASCULAR INVASION IS NOT APPRECIATED (see comment). E. DUCTAL CARCINOMA IN-SITU, SOLID TYPE, NUCLEAR GRADE 2, WITH COMEDONECROSIS, REPRESENTING ABOUT 1 % OF TUMOR VOLUME. F. DUCTAL CARCINOMA IS PRESENT ADMIXED WITH INVASIVE TUMOR. G. MARGINS OF RESECTION ARE FREE OF TUMOR. H. nIpple, nO tumor iS Seen. I. SkIn, free Of tumOR. J. CHANGES CONSISTENT WITH PREVIOUS CORE bIOPSY SITE, K. LOBULAR CARCINOMA IN-SITU, CLASSIC TYPE WITH PAGETOID SPREAD INTO DUCTS (See COmment). L. ATYPICAL LOBULAR HYPERPLASIA (see comment)). M. MULTIPLE MICROSCOPIC RADIAL SCARS WITH FLORID DUCTAL EPITHELIAL HYPERPLASIA AND XOLUNAR CELL CHANGES. N. INTRADUCTAL PAPILLOMA INVOLVED WITH INFILTRATING LOBULAR CARCINOMA. O. FIBROCySTIC CHAnGES WITH FIBROADENOmATOID NODULAR CHAnGES. P.PSEUDOANGIOMATOUS STROMAL HYPERPLASIA (PASH). Q. IMMUNOHISTOCHEMICAL STAINING FOR ESTROGEN RECEPTOR, PROGESTERONE RECEPTOR AND HER- 2/NEU WERE PREVIOUSLY PERFORMED ON AND WERE REPORTED AS FOLLOWS: ESTROGEN RECEPTOR-POSITIVE (H-SCORE 29O),PROGESTERONE RECEPTOR-POSITIVE (H-SCORE 200), AND HER-2/NEU -- EQUIVOCAL (SCORE 2+). HER-2 FISH WAS NOT AMPLIFIED. zQD-O 3 Lobeulss reinomdrnyiltatino 86a0|3 @Buast csb9 Sete J) 4/QQ[14
+
+--- Page 2 ---
+Anonymous No.: Age:  Gonder: F Race: White CLINICAL HISTORY Procedure: Lett total mastectomy, left sentinel lymph node biopsy, possible axillary lymph node dissection Number ot Lesions: 1 Site and Size Lesion 1: 9 cm, Histology: invasive lobular carcinoma Other Areas: Not provided Neoadjuvant Therapy: No Type of Neoadjuvant Therapy: N/A Pretherapy Size: N/A Clinical Findings Based On: MRi, ultrasound and mammogram. Comment: None listed ADDENDUM Tumor characteristics Size: 8 cm Nottingham score:  6 ER H-score: 290 PR H-score: 200 HER2 status:Negative Ki-67 labeling index:30. Based on above tumor characteristics, the estimated recurrence score.  using is reported below. 1 (includes a-f): 22.59 2 (includes a-e): 16.19 3 (includes c-f):17.82 NOTE For more scientific details, see reference: Klein ME et al. Mod Pathol.. 2013;26:658-664. PMID: 23503643. ADDENDUM This infiltrating lobular carcinoma is heterogeneous and show microscopic. toci of pleomorphic tumor component (intiltrating pleomorphic iobular. component). This case is discussed with I. on FINAL DIAGNOSIS PART 1: LYMPH NODE, LEFT AXILLA SENTINEL NODE #1, 8IOPSY METASTATIC ADENOCARCINOMA INVOLVING ONE LYMPH NODE (1/1), UP TO 7 MM (1A). CONFiRMED BY AE1/AE3 CYTOKERATINE IMMUNOSTAINING ( (see COmment). PART 2: LymPh NODE, LEfT AXiLLA, SENTINEL #2, BIOPSY METASTATIC ADENOCARCINOMA INVOLVING ONE LYMPH NODE (1/1), UP TO 7 MM (2B), CONFIRMED BY AE1/AE3 CYTOKERATINE IMMUNOSTAINING ( (see comment). PART 3: LYMPH NODE, LEFT AXILLA, SENTINEL #3, BIOPSYE  METASTATIC ADENOCARCINOMA INVOLVING ONE LYMPH NODE (1/1), UP TO 4 MM
+
+--- Page 3 ---
+(3A), CONFIRMED BY AE1/AE3 CYTOKERATINE IMMUNOSTAINING ( (see comment). PART 4: LYMPH NODE, LEFT AXILLA, SENTINEL #4, BIOPSY ONE LYMPH NODE, FREE OF TUMOR (0/1), (see comment). PART 5: BREAST, LEFT, TOTAL MASTECTOMY A. INFIULTRATING LOBULAR CARCINOMA (5C, 5D, 5E, 5F, 5H, 5I, 5J, 5K, 5L, 5M, 5N, 50, 5P, 5Q, 5R, 5S, 5T, 5U, 5V, and 5AA}. B. THE TUMOR SIZE IS: 8.0 X 6.5 X 4.2 CM. C. NOTTINGHAM SCORE iS: 6/9 (TUBULES 3, NUCLEI 2, MITOSIS 1). D. LYMPHOVASCULAR INVASION IS NOT APPRECIATED (see comment). E. DUCTAL CARCINOMA IN-SITU, SOLID TYPE, NUCLEAR GRADE 2, WITH COMEDONECROSIS, REPRESENTING ABOUT 1 % OF TUMOR VOLUME. F. DUCTAL CARCINOMA IS PRESENT ADMIXED WITH INVASIVE TUMOR. G.  MARGINS OF RESECTION ARE FREE OF TUMOR. H. NIPPLE, NO TUMOR IS SEEN. SKIN, FREE OF TUMOR. J. CHANGES CONSISTENT WITH PREVIOUS CORE BIOPSY SITE, SEE PRIOR K.  LOBULAR CARCINOMA IN-SITU, CLASSIC TYPE WITH PAGETOID SPREAD INTO DUCTS (see comment). C. ATYPICAL LOBULAR HYPERPLASIA (see comment). M.  MULTIPLE MICROSCOPIC RADIAL SCARS WITH FLORID DUCTAL EPITHELIAL HYPERPLASIA AND XOLUNAR CELL CHANGES. N. INTRADUCTAL PAPILLOMA INVOLVED WITH INFILTRATING LOBULAR CARCINOMA. O. FIBROCYSTIC CHANGES WITH FIBROADENOMATOID NODULAA CHANGES. P.  PSEUDOANGIOMATOUS STROMAL HYPERPLASIA (PASH). Q. IMMUNOHISTOCHEMICAL STAINING FOR ESTROGEN RECEPTOR, PROGESTERONE RECEPTOR AND HER-2/NEU WERE PREVIOUSLY PERFORMED ON. AND WERE REPORTED AS FOLLOWS: ESTROGEN RECEPTOR POSITIVE (H-SCORE 29O), PROGESTERONE RECEPTOR POSITIVE (H-SCORE 200). AND HER-2/NEU EQUIVOCAL (SCORE 2+). HER-2 FISH WAS NOT AMPLIFIED. COMMENT Part # 1, # 2, # 3, # 4, and # 5: The results of immunohistochemical stainings support the above diagnosis (see microscopic description). Parts #1, #2 and #3: The metastatic tumor cells with thin these lymph nodes are depicted by the AE1/AE3 cytokeratin immunostaining and are present circumferentially within the sub capsular sinusoidal area in minute tumor cell clusters and mostly as single cells. Re- review of the imprint slides performed at intraoperative consultation showed no metastatic tumor cells in part 1 and part 2, and showed rare atypical cells in part 3.. GROSS DESCRIPTION The specimen is received fresh and in 5 parts. Part 1 is received for intraoperative consultation labeled with the patient's name, initials  and "sentinel node biopsy #1 left axilla, not blue". It consists of a portion of  adipose tissue which measures 2.5 x 1.5 x 1.2 cm. A single pink tan probable lymph node. is identified measuring 1.5 x 1.1 x 0.8 cm. The lymph node is bisected for touch preparation to reveal a homogenous tan-yellow cut surface. The lymph node is further bisected longitudinally into 2-mm intervals and submitted entirely in two cassettes labeled
+
+--- Page 4 ---
+1A-1B. Formalin Exposure Time: 13 hours Part 2 is received for intraoperative consultation labeled with the patient's name, initials T and "sentinel node biopsy #2 left axilla. not blue". It consists of a single fatty pink. tan probable lymph node with minimal attached adipose tissue which measures 2 x 1.7 x 1 cm. The lymph node is bisected for touch preparation analysis to reveal a largely fatty replaced cut surface. The lymph node halves are further bisected into 2-mm longitudinal intervals and submitted entirely in two cassettes labeled 2A-2B.. Formalin Exposure Time: 13 hours Part 3 is received for intraoperative consultation labeled with the patient's name, initials . and "sentinel node biopsy #3 ieft axilla ...- not blue'. It consists of a portion of  adipose tissue which measures 4 x 3 x 1.5 cm. A single fatty pink tan probable lymph node is identified measuring 1.5 x 1 x 0.8 cm. The lymph node is bisected to reveal a largely fatty replaced cut surface. One half the lymph node is submitted for frozen section  analysis. Both halves of the lymph node are further bisected into 2-mm longitudinal intervals and submitted entirely as follows:. 3FS- lymph node half, frozen section. 3A- remaining lymph node halves. Formalin Exposure Time: 13 hours Part 4 is labeled with the patient's name, initials I and *sentinel node biopsy #4 left axilla not blue'. It consists of a portion of adipose tissue which measures 4.0 x 2.7 x 1.0 cm. A single pink tan probable lymph node is identified measuring 2.0 x 1.3 x 0.6 cm. The lymph node is bisected to reveal a pink-tan cut surface interspersed with adipose tissue. The lymph node halves are further sectioned into 2-mm longitudinal intervals and submitted entirely in two cassettes labeled 4A-48. Formalin Exposure Time: 13 hours Part 5 is labeled with the patient's name, initials  and *left total mastectomy long lateral short superior". It consists of a 1202 g total mastectomy specimen which measures 23.5 x 22 x 7.5 cm. The anterior surface is remarkable for an ellipse shaped portion.of light tan skin which measures 20 x 16 cm. The areola measures 6.5 x 6 cm with a 1.1-cm retracted, mobile nipple. No discrete skin scars or lesions are grossly identified. The  specimen is inked and sectioned to reveal a large, ill-defined stightly stellate mass (ring. shaped biopsy clip) which is located roughly between the upper outer and lower outer quadrants, and extends towards the central aspect of the breast. The mass measures 8.0 x 6.5 x 4.2 cm and comes to within 1.0 cm of the closest posterior margin, 2.2 cm of the skin and 3 cm of the anterior inked margin. The breast parenchyma directly medial of the mass and encompassing a large portion of the upper inner and lower inner quadrants is dense and extensively fibrocystic (approximately 10 x 4.5 x 4 cm). No additional masses are identified grossly. The uninvolved breast parenchyma is composed of approximately 50% adipose tissue and 50% nodular fibrous tissue. Representative sections are submitted as follows: 5A- nipple and subareolar soft tissue 5B- breast parenchyma directly lateral of mass. 5C- fullface mass (most lateral aspect) 5D-5K- fullface mass (central lateral aspect), 5D-5G- posterior aspect, 5E-5K= anterior aspect 5L-5S- fullface mass (central medial aspect), 5L-5O= posterlor aspect, 5P-5S= anterior aspect 5T-5U- fullface mass (most medial aspect). 5V- breast parenchyma directly medial of mass. 5W-5Y- fibrocystic tissue adjacent to the mass
+
+--- Page 5 ---
+5Z-5AA- posterior inked margin closest to mass 5AB- anterior inked margin closest to mass 5AC- lower outer quadrant 5AD- lower inner quadrant 5AE- upper inner quadrant 5AF-upper outer quadrant Block 1-left breast tumor intiltrating lobular carcinoma. Block 2-left breast normal fibrocystic changes. Upper outer quadrant- green Lower outer quadrant- red  Upper inner quadrant- black Lower inner quadrant- blue Anterior- orange. Cold ischemic time: 28 minutes Formalin exposure time: 12 hours 30 minutes MICROSCOPIC DESCRIPTION Microscopic examination substantiates the above dlagnosis.. The results of immunohistochemical staining are as follows for Part 1, 2, 3, and 4: Antibody/Antigen Result AE1-AE3 Positive in the metastatic tumor cells in parts1, 2 & 3, negative in 4. The results of immunohistochemical staining are as follows for Part 5: Antibody/Antigen Result E-Cadherin Negative P120 Positive cytoplasmic expression in lobular cells D240 Highlights lymphatic spaces; no tumor cells within lymphatic. spaces. CD31 Highlights vascular c spaces; no tumor cells within vascular. spaces. Utilizing formalin-fixed (8-96 hour range), paraffin embedded tissue, immunohistology is pertormed with the following selected antibodies and designated antibody clone(s), directed against the tollowing antigenic target(s), with adequate positive and negative internal and external controls. Antibodies are optimized appropriate for fixation times. ANTIBODY CLONE TARGET ANTIGEN VENDOR AE1/AE3 AE1/AE3 carcinomas e-cadherin 36 Lobular Differentiation p120 98 Lobular Differentiation D2-D2-40 D2-40 Lymphatic Endothelium CD 31 JC70 endothelium INTRAOPERATIVE DIAGNOSIS 1TP: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #1, NOT BLUE (touch preparation)- A. SUFFICIENT FOR ANCILLARY STUDIES B. BENIGN C. LYMPH NODE
+
+--- Page 6 ---
+2TP: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #2, NOT 8LUE (touch preparation)- A. SUFFICIENT FOR ANCILLARY STUDIES B. BENIGN C. LYMPH NODE  3FS/TP: LYMPH NODE, LEFT AXILLA, SENTINEL NODE BIOPSY #3, NOT BLUE (ftrozen section and touch preparation)- A. SUFFICIENT FOR ANCILLARY STUDIES B. DEFER C. LYMPH NODE WITH ATYPICAL CELLS
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diff --git a/output/text/c6d69e34-f142-4425-8fd8-bed6ccf50eca.txt b/output/text/c6d69e34-f142-4425-8fd8-bed6ccf50eca.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a2bad4dab0fa40088201c83e89a6937c8fc9698c
--- /dev/null
+++ b/output/text/c6d69e34-f142-4425-8fd8-bed6ccf50eca.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+ics-0-3 Ad(anocercinenr, mucnous,Nos 8480f3 Sitv cdc: Sp/enic flexuu z ciwn C18.5 o UUID: A73A51CC-SDDB-4D1D-ABDC-858856CC388D TCGA-DM-A1D6-01A-PR Redacted (First Tumor) Tumor Site: Splenic Flexure Distal .. Date of Cancer Sample Procurement: Histology: Adenocarcinoma Description of other histology:n. Grade: Moderately Differentiated Mucinous: C Yes r No  Yes C Unknown (Focal) Signet Ring Feature:. C Yes  No ( Yes C Unknown (Focal) Histologic Heterogeneity:.  No C Yes C Unknown Host Response:. Lymphoid Aggregates Crohn's like reaction C None  Yes C Unknown Plasma cell rich stroma C No C Yes C Unknown Growth Pattern: C Expansile C Expansile  Invasive C Unknown and Invasive Inflammatory Bowel Disease O No C. Yes C Unknown Angiolymphatic Invasion: O No  Yes C Unknown Mutator Phenotype: C No  Yes C Unknown Number of Slides 1 Garland Necrosis present:. 6 No C Yes C Yes r Unknown (Focal) TIL Cells/ HPF o Pathologist Comment:
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diff --git a/output/text/c6de9b97-06ac-4da3-88da-0ee0fb95fc1f.txt b/output/text/c6de9b97-06ac-4da3-88da-0ee0fb95fc1f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..950c4afe600c5ad639ac9fd90a345e334b2d7d8d
--- /dev/null
+++ b/output/text/c6de9b97-06ac-4da3-88da-0ee0fb95fc1f.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+path report Microscopic Sections designated as "parietal tumor or parietal pericystic" demonstrate infiltrating or mildly cellular diffuse glioma. The tumor cells are characterized by round nuclei that lack obvious processes and perinuclear halos. The sections that are designated as arising inone of two cysts show markedly hypercellular tumor with essentially identical histologic features. They do have modestly greater hyperchromasia but this may reflect cell density. Only rare mitotic figures are seen. There is no microvascular proliferation or necrosis. Addendum MIB-1 reactivity varies significantly within the tumor. It ranges from 0.7% in the least proliferative areas up to 9.7%. Whereas this is worrisome for early anaplastic progression, the diagnosis f grade Ill anaplastic oligodendroglioma cannot be made on this alone. Diagnosis Oligodendroglioma, grade II.
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diff --git a/output/text/c6fd46ed-d506-494e-ac21-ae7c1087fe2b.txt b/output/text/c6fd46ed-d506-494e-ac21-ae7c1087fe2b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b5a8cdc51317d20e1cec2877453c2112158e4aa7
--- /dev/null
+++ b/output/text/c6fd46ed-d506-494e-ac21-ae7c1087fe2b.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UUID: 45B099D5-2E5F-4B70-9B17-D37BC5CA0D40 TCGA-DK-A3X1-01A-PR Redacted SURGICAL PATHOLOgY REPORT Patient Name: Accession #: Med. Rec. #: Date of Procedure: DOB: (Age: Location: Date of Receipt: Gender: Service:  Lroiogy Date of Report: Ref. Physician: Account #: Patient Address: Billing Type: Additional Copy to: Ref. Source: Clinical Diagnosis & History:. ' year old with pT2 urothelial cell carcinoma, status post 2 courses of BCC. Specimens Submitted: 1: SP: Uterus, cervix, bilateral tubes and ovaries anterior vaginal wall, bladder, perivesical lymph nodes. 2: SP: Right distal pelvic lymph nodes. 3: SP: Left pelvic lymph node 4: SP: Left distal pelvic lymph nodes 5: SP: Right distal ureter 6: SP: Left distal ureter DIAGNOSIS:  SP: Uterus, cervix, bilateral tubes and ovaries anterior vaginal wall, bladder, perivesical lymph nodes: Tumor Type: Invasive urothelial carcinoma, NOS Histologic Grade: High grade 1cDo-3 Pattern of growth of the Non-Invasive component:. In situ component not identified. Carcinoma uO4hl;g1, NO5 Pattern of growth of the Invasive component: 81aoJ3  Infiltrating Tumor Multicentricity: S ik:bladkler, dom Not identified Bladder Local Invasion: C67.1 Perivesical soft tissues 5Z31z sp Extravesical Tumor Extension:e Ureters uninvolved Vascular Invasion: No definite vascular invasion present. Perineural Invasion: Not identified Surgical Margins: Free of tumor See also parts 5 and 6 Non-Neoplastic Mucosa: Exhibiting chronic cystitis Exhibiting foreign body reaction. Page 1 of 5
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT Female Genital Organs: The endometrium shows endometriai polyp The myometrium shows mural leiomyomas The left fallopian tube shows simple serous cysts. The right ovary shows hilus cell and stromal hyperplasia. The left ovary shows stromal hyperplasia  Remaining genital organs are unremarkable Perivesical Lymph Nodes: LN Not involved 0/1 The Pathologic Stage is (AJCC  pT3 (Invasion of perivesicle soft tissue) SP: Right distal pelvic lymph nodes: Lymph Nodes: Not involved  Number of nodes examined:2 3. SP: Left pelvic lymph node: Lymph Nodes: Not involved Number of nodes examined:8 SP: Left distal pelvic lymph nodes: Lymph Nodes: Not involved Number of nodes examined:8 5. Right distal ureter; excision: - Ureter with focal mild atypia. 6. Left distal ureter; excision: - Benign ureter. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT ! HAVE REVIEWED AND APPROVED THIS REPORT. *** Report Electronically Signed Out *** Gross Description: 1) The specimen is received fresh, labeled "uterus, cervix, bilateral tubes and ovaries, anterior vaginal wall, bladder and perivesical lymph nodes". It consists of a cystectomy-hysterectomy and bilateral salpingo-oophorectomy specimen measuring 11 cm from superior to inferior, 12cm laterally and 5cm from anterior to posterior. The bladder measures 13 x 11cm, the uterus measures 5 x 4.6 x 2.8 cm, the right ovary measures 2.2 x 1.0 x 0.9 cm, the right fallopian tube measures 5.4 x 0.7 cm, the left ovary measures 2.7 x 1.3 x 0.9 cm, and the left fallopian tube measures 4 x 0.7 cm. The portion of vaginal cuff measures 5.5 x 2.0 cm. The distal urethral margin and the vaginal cuff margin are shaved and submitted. The ureteric stumps are buried in the specimen, measure approximately 2 cm and show probe-patent lumen. The specimen is inked black for posterior, blue for anterior and the bladder is opened anteriorly to reveal a friable fungating mass measuring 3.3 x 2.4 cm located in the dome focally extending to trigone. The  distance from the left and the right ureteric orifices are 5.2 cm and 5.3 cm respectively. On sectioning, the tumor extends to a depth Page 2 of 5
+
+--- Page 3 ---
+SURGICAL PATHOLOGY REPORT of 2.0 cm, and appears to extend into the perivesicai fat grossly reaching to the subserosa. The remaining bladder mucosa shows  flat mucosa without additional lesion. Discrete perivesical lymph nodes are not identified. The uterus is bivalved to reveal multiple  fibroids ranging from 0.5 to 1.5 cm and endometrial polyp measuring 2 x 1.2 x 0.2 cm. The ovaries and fallopian tubes are  unremarkable. Tissue is submitted for Gross photograph is taken. Representative sections are submitted.. Summary of sections: UTHM - urethral margin RUM - right ureter margin LUM -left ureter margin L -lesion RUO -right ureteric orifice LUO -left ureteric orifice  LP-left posterior wall LA -left anterior wall RP-right posterior wall  RA -right anterior wall TRI -trigone EMM -endomyometrium CX-cervix V -- vagina, full thickness to include bladder mucosa. DVM -distal vaginal margin RTO -right tube and ovary LTO-left tube and ovary LN -- possibie lymph node 2). The specimen is received fresh , labeled "Right distal pelvic lymph nodes" and consists of 2 pink tan firm lymph nodes measuring 0.7 x 0.6 cm and 2.0 x 1.0 cm in greatest dimension. The larger lymph node is inked black and bisected. All identified Iymph nodes are submitted. Summary of sections: LN -- lymph nodes 3). The specimen is received fresh labeled "Left pelvic lymph nodes".  It consists of muitiple lymph nodes ranging from 0.2 x 0.2 cm up to 3 x 1.8 cm. The lymph nodes are serially sectioned at 3 mm intervals and submitted.. Summary of sections: LN-lymph nodes BLN-bisected lymph node LN1-lymph node number one LN2-lymph node number two LN3-lymph node number three 4).The specimen is received fresh, labeled "Left distal pelvic lymph node" and consists of multiple pink tan firm lymph nodes ranging from 0.2 x 0.2 cm up to 3.5 x 1 cm in greatest dimension. All identified lymph nodes are submitted. Summary of sections:  LN -- lymph nodes BLN-- bisected lymph node 5). The specimen is received in formalin labeled "Right distai ureter unclipped is a margin." It consists of a segment of ureter measuring 5 cm in length and 0.4 cm in diameter. The attached adipose tissue measures up to 1.5 cm in thickness. There is a clip on one end of the specimen. The specimen is serially sectioned from the clipped to the non-clipped end and submitted entirely. Summary of sections: MC-margin with clip  SS-serial sections from clipped to non-clipped end. Page 3 of 5
+
+--- Page 4 ---
+SURGICAL PATHOLOGY REPORT margin without clip 6). The specimen is received in formalin labeled "Left distal ureter unclipped is a margin." It consists of a segment of ureter measuring 3.5 cm in length and 0.4 cm in diameter. The attached adipose tissue measures up to 1.5 cm in thickness.  There is a clip on one end of the specimen. The specimen is serially sectioned from the clipped to the non-clipped end and submitted entirely. Summary of sections: MC-margin with clip SS-serial sections from clipped to non-clipped end MWC-margin without clip Summary of Sections: Part 1:  SP: Uterus, cervix, bilateral tubes and ovaries anterior vaginal wall, bladder, perivesical lymph nodes Block Sect. Site  PCs 1 cx 2 1 dnm 1 2 emm 2 6 6 1 la 2 1 LN 1 1 lof 2 1 1p 2 1 lum 1 1 luo 1 1 ra 2 rof 2 1 rp 1 1 rum 1 1 ruo 1 1 tri 1 1 uthm 1 1 v 1 Part 2:  SP: Right distal pelvic lymph nodes Block Sect. Site PCs 1 In 1 Part 3:  SP: Left pelvic lymph node Block Sect. Site PCs 1 bln 1 1 In 1 2 In1 2 2 In2 2 2 In3 2 Part 4:SP: Left distal pelvic lymph nodes  Block PCs Sect. Site 1 BLN 1 1 LN 1 Part 5:  SP: Right distal ureter Block Sect. Site PCs 1 mc 1 Page 4 of 5
+
+--- Page 5 ---
+SURGICAL PATHOLOgY REPORT 1 mwc 1 1 1 ss Part 6:  SP: Left distal ureter. Block Sect. Site PCs 1 MC 1 MWC 1 ss Page 5 of 5 END OF REPORT
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diff --git a/output/text/c70f117c-4b16-4f25-beba-e098a3cb467d.txt b/output/text/c70f117c-4b16-4f25-beba-e098a3cb467d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..272ca60e27e141d34b141adda88cdfd9c23acf85
--- /dev/null
+++ b/output/text/c70f117c-4b16-4f25-beba-e098a3cb467d.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Patient Name Accession #: Med. Rec. #: Date of Procedure. DOB: Date of Recelpt Gender: Date of Report Ret Physician: Account #: Patient Address: Billing Type Additional Copy to. Ref Source. cis & History: h 1.5 cm left lower pole renal mass. Specimens Submitted: 1: Kidney. left lower pole, partial nephrectomy. 2: Kidney, left lower pole cyst, excisio DIAGNOSIS: Kidney, lelt lower pole, partial nephrectomy Tumor Type:  Renal cell carcinoma - Papillary lype Fuhrman Nuclear Grade:  Nuclear grade III/IV Tumor Size: Greatest diameter is 1.5 cm. Local Invasion (for renal cortical types): Extends through renal capsule bul confined within Gerota's fascia. Renal Vein Invasion: Not identified Surgical Margins: Free of tumor The tumor is focally present approximately 1 mn trom the inked soft tissue margin surrounding Ihe kidney. The. closest kidney resection margin is 0.5 cm. Non-Neoplastic Kidney: Unremarkable Adrenal Gland: Not identified I.ymph Nodes: Not identified  Staging tor renal cell carcinoma/oncocytoma:  pT3a Tumor invades the adrenal gland or perinephric lissues but not beyond Gerota's lascia. Note: Immunohistochemical stains were performed and the tumor is posltive for CK7 and racenase, il is negalive for CK20 while it shows granular, non-specific staining for c-kit, 34BE 12 and 4A4.  Ihis immunoprotile is consistent with the diagnosis of papillary renal cell carcinoma. 2. Kidney cyst, left lower pole, exclsion: Page 1 01 3
+
+--- Page 2 ---
+Benign renal cyst. TATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MIY PERSONAL EXAMINATION OF THE SLIDES (AND/OR QTHER MATERIAL), AND THAT IHAVE REVIEWED ANO APPROVED THIS REPORT : Special Studies: Result Special Stain Comment CK7 CK20 TTF-1 RACEMASE JMM RECUT NEG CONT 4A4/P63 348E12 CD117 RECUT IMM RECUT  NEG CONT Gross Description: 1). The specimen is receivod fresh for frozen section consultation and is labeled "Left renal tumor, lower pole" It consists of a 3.5 x 2.5 x 2 cm wedge shaped portion of kidney with a suture narking the deep margin. The margin is inked black, the remaining surface is inked green and the specimen is serially sectioned to reveal a brown tan , fairly circumscribed focally hemorrhagic tunor.  measuring 1.5 x 1.2 x 1cm. The cloarance from the reseclion margin is 0.5 cm. A representalive section of the nearest margin is submitted for frozen seclion diagnosis. Entirely submitted. Portions of the tumor are submitted for TPS. Summary of sections. FSC - frozen seclion control. T - tumor M-margin RS - remaining sections. 2). Ihe specimen is received in formalin, labaled "Loft lower pole kidney cyst' and consists of a lwo fragment of tan soft tissue,  measuring 1.6 and 3.2cm in grealest dimension.. Entirely submitted. Summary of sections: U - undesignated Summary of Sections: Part 1:  Kidney, left lower pole, partial nephrector. Block Sect. Site PCs 1 F$C 1 1 M 1 2 RS 4 1 T 1 Part 2:  Kidney, left lower pole cyst, excisior Block Sect. Site pC$ 1 U 2 Page 2 01 3
+
+--- Page 3 ---
+Intraoperative Consultation: consultation FROZEN SECTION DIAGNOSIS: SP: LEFT RENAL. TOMOR, LOWER POL NEGATIVE; RENAL CORTICAL NEOPLASM SUSPECT PAPILLARY TYPE (Ft:EDSTEIN). EEP INKED MARGIN PERMANENT DIAGNOSIS: SAME Page 3 of 3 END OF REPORT
\ No newline at end of file
diff --git a/output/text/c711af95-1f27-459a-a3dc-e92e37490f0d.txt b/output/text/c711af95-1f27-459a-a3dc-e92e37490f0d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5d824ffc06b991e32c34916b327a14920d81a886
--- /dev/null
+++ b/output/text/c711af95-1f27-459a-a3dc-e92e37490f0d.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+Patient Name Accession #: Med. Rec. #: Date of Procedure DOB. Date of Receipt Gendor. Date of Report: Ret. Physician: Account #: Patient Address Billing Type. Additional Copy to: Rel. Source: Clinical Diagnosis & History: Inckdiental finding ol 9cm right renal mass with renal vein thrombus into IVC. Specimens Submitted: 1: SP: Kidney, right with inferior vena cava thrombus, radical nephrec 2: SP: Adrenal gland right and super hitar lymph nodes, reseclion 3: SP:Lymph nodes, pericaval and paracaval resection 4: SP: Lymph nodes. precaval, resection DIAGNOSIS: 1.* sP: Kidney, right with interior vena cava thrombus, radical nephrectom Tumor Type: Renal cell carcinoma - Unclassified type with clear cell and papillary features. See nole. Tumor Size: Greatest diameter is 9 cm.. Local Invasion (for renal corical types): Extends inlo renal.pelvis. Renal Vein Invasion Identified Gross renal vein thrombus is identified Surgical Margins: Tunor cells are noted in tho section of renal vein margin. However, pet e observed renal vein margin were clear. Non-Neoplastic Kidney. Unremarkable Adrenal Gland: Not identified Lymph Nodes. Free of tumor Number of metastatic nodos:0 Number of nodes examined:3  Staging for renal cell carcinoma/oncocyloma:  pT3b Tunor grossly extends into the renal vein(s) or vena cava below the diaphragm Page 1 of 4
+
+--- Page 2 ---
+NOTE: The tumor demonstrates combination of papillary and clear cell features. Foci of lympho-vascular invasion are scen.. The malignant cells show posilive immunoreactivity for CAM 5.2 ( palchy), CD10, CA IX (patchy, weak), Rasemase (. granular, patchy) while being negative for AE1/ AE3, HMB 45, CK7, RCC, 34BE12 and TFE3. The innunoprofile and morphological feaiures nosl compatible with unclassified type of renal cell carcinoma.. 2.  Right adrenal.gland and super hilar lymph nodes, excision:  Benign adrenal gland and benign fibro-adipose tissue. No lymphoid tissue identified.. 3. SP:Lymph nodes, pericaval and paracaval, resection:. Lymph Nodes: Not involved Number of nodes examined:11 Nunber of metastatic nodes:0 SP: Lymph nodes, precaval, resection. Lymph Nodes. Not involved Number of nodes examined:7 Number of metastatic nodes:0. TATTEST IHAT THE ASOVE DIAGNOSIS IS BASEO UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERAL), AND THAT IHAVE REVIEWED AND APPROVED THIS REPORT Special Studies: Result Special Stain Comment CK7 CA-1X. RCC NEGATIVE CD10 34BE12 RACEMASE RECUT NEG CONT IMM RECUT AE 1:AE3 CAM 5.2 HMB46-RED. H&E(US) Gross Description: 1).The specimen is received fresh for TP$ labeled "righl kidney with inferior vena cava thrombus" and consists of a kidney with altached ureter, renal vessels and perinephric lat weighing 919 g in tolal.. The kidney neasures 13.5 x 7.0 x 6.0 cn.The attached ureter measures 4.5 cm in length and 0.2 cm in diameter. The atlached renat vein measures 1.5 cm in lenglh and 1.0 cm in diameter and is grossly involved by tumor thrombus at the margin. The ureter margin is grossly unremarkable.  An adrenal Page 2 of 4
+
+--- Page 3 ---
+gland is not identified. The kidney is inked black and bivalved to reveal a light tan soff fairly well-circumscribed tumor mass measuring 9.0 x 6.5 x 5.5 cn. It has focal areas of necrosis, hemorrhage and cystic degeneration. Mulliple satellite nodules are  also identified. The lumor abuts the capsule and grossly involves the sinus and hilar fat . Sections through the remainder of the  kidney reveal a pink brown parenchyma, with a welldefined corticomedullary junction. The cortex measures O.7 cm and the. calyces appear normal. One lyimph node is identified and submitted. Representalive sections are submilled for TPS and for permanent sections. The specimen is photographed. 1 r i. Summary of sections: UVM -- ureteral and vessel margins T--tumor THF-- tumor with hilar fat TSF -- tumor wilh sinus fat TK -- tumor with adjacent kidney RP -- renal peivis representative seclions K -- sepresenlative sections kidney KC-tumor and capsule LN-lymph node 2).  The specimen is received in formalin labeled *Right adrenal gland and super hilar lymph nodes" and consists of a 7.5 x 3.0 x 2.8 cm adrenal gland with abundant altached adipose tissue, with a Irimmed weight of 7.9 g. The specimen is serially sectioned to reveal an unremarkable yellow red cortical medullary cul surface with 0.5 x 0.3 cm red-brown hemorrhagic focus involving the cortex. Within the fat there are mulliple pink-yellow lymph nodes averaging O.4 cm which are submitted in their enlirety, addilionat possible lymphoid tissue is enlirely subinitted. Representative sections are submitted.. Summary of sections: A- Adrenal LN -Jymph nodes LT- lymphoid tissue 3). The specimen is received in formalin, labeled "pericaval and paracaval lymph nodes" and consists of multiple pink tan firm. Iymph nodes ranging from 0.3 to 0.7 cm in greatest dimmension. All identified lynph nodes are submitted. Summaly ol sections. LN -- lymph nodes Add. Additional sections of lymph nodes. 4). The specimen is received in formalin, labeled "precaval tymph nodes" and consists of rnulliple pink tan firm lymph nodos ranging from 0.3 to 1.1 cm in greatest dimension.*- The largest lymph node is bisecled and all identified lymph nodes are. submitted. Summary of seclions. LN -- lynph nodes BLN-- bisected lymph node Summary of Sections: Part 1:  SP: Kidney, right with inferior vena cava thrombus, radical nephrectomy. 8lock Sect. Site PCs 1 k 1 kc 3 : 1 In 1 2 rp 2 3 t 3 2 tht 2 Page 3 nf 4
+
+--- Page 4 ---
+tk 2 tst 2 2 uvn 2 Part 2: SP: Adrenal gland right and super hilar lymph nodes, resectior Block Sect. Site PCs 3 A 3 1 LN 1 1 LT 1 Part 3: SP:Lymph nodes, pericava! Iand paracaval , resection Block Soct. Site PCs 3 add 3 1 LN 1 Part 4:  SP: Lymph nodes, precaval, re$ecti Block Sect. Site PCs 1 BLN LN Page 1 0l 4 END OF REPORT
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diff --git a/output/text/c7214095-92bd-4234-bb9a-11100b6f2d90.txt b/output/text/c7214095-92bd-4234-bb9a-11100b6f2d90.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5897e85b789332a9c1d1bf34e316e5087a1bff60
--- /dev/null
+++ b/output/text/c7214095-92bd-4234-bb9a-11100b6f2d90.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Clinical Diagnosis & History: /o male with incidental right renal mass.. Specimens Submitted: 1: SP: Right kidney, adrenal gland and hilar lymph node DIAGNOSIS: 1) KIDNEY AND ADRENAL GLAND, RIGHT RADICAL NEPHRECTOMY: - RENAL CELL CARCINOMA, CHROMOPHOBE CELL TYPE, NUCLEAR GRADE II/IV. - THE PATTERN OF GROWTH IS SOLID - THE TUMOR GREATEST DIAMETER IS 6.8 CM. - THE TUMOR IS CONFINED WITHIN THE RENAL CAPSULE -ALL SURGICAL MARGINS ARE FREE OF TUMOR -VASCULAR INVASION IS PRESENT. (SEE NOTE.) -THE NON-NEOPLASTIC KIDNEYIS UNREMARKABLE. - THE ADRENAL GLAND IS UNREMARKABLE. - THE LYMPH NODE STATUS IS AS FOLLOWS (EXPRESSED AS THE NUMBER OFMETASTATIC NODES IN RELATION TO THE TOTAL NUMBER OF NODES EXAMINED): RENAL HILAR: O/1. NOTE: A REPRESENTATIVE SLIDE WAS REVIEWED WITH DR. REUTER WHO CONCURS I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Gross Description: 1) The specimen is received fresh, labeled "Right Kidney, Adrenal Gland and Hilar Lymph Node". It consists of a radical nephrectomy specimen, including right kidney, adrenal gland and attached perinephric adipose tissue, entirely weighing 550 grams and measuring 15 x 10 x 5.5 cm.The adrenal gland is identified and it measures 4.5 x 2 x 0.7 cm. It is separated from the renal. parenchyma by 2.5 cm of perinephric adipose tissue. The adrenal gland is serially sectioned and appears grossly unremarkable.. The ureter is identified and it measures 2 cm in length x 0.3 cm in diameter.  Renal vessels are present and measure from 0.5 to. 0.7 cm in length x 0.3 cm in diameter..  The renal vessels and the distal ureter appear grossly unremarkable.  Multiple hilar lymph nodes are identified, ranging in size from 0.3 to 0.5 cm.  The kidney is bivalved revealing a well-circumscribed, partially encapsulated, tan-beige to light yellow mass measuring 6.8 x 6.5 x 3.8 cm located at the upper pole. Serial sectioning of the mass. reveals cystic degeneration with very minimal hemorrhagic and necrotic areas.The cystic component comprises about 20% of the entire mass and the solid component comprises 80% of the mass. The mass is 0.7 cm from the renal pelvis. The mass appears to be confined within the renal parenchyma and within the renal capsule.  No gross invasion of the vessels or perinephric fat is identified.The cortical-medullary junction is distinct. The cortical thickness ranges from O.7 to 1 cm.The uninvolved renal parenchyma is tan-beige and appears grossly unremarkable. The renal capsule is easily stripped revealing a smooth Page 1of2
+
+--- Page 2 ---
+renocortical surface. The cortical surface is tan and smooth. Photographs are taken. Representative sections are submitted for EM and TPS.Representative sections are submitted. Summary of Sections: UM- ureter margin RV - renal vessels HLN-hilar lymphnodes AG - adrenal gland closest to the kidney RP - renal pelvis closest to the tumor NK - normal-appearing kidney T-tumor PNF -- closest perinephric fat Summary of Sections: Part 1: SP: Right kidney, adrenal gland and hilar lymph node. Block Sect. Site PCs 1 AG 2 1 HLN 2 2 NK 2 2 PNF 4 2 RP 2 1 RV 4 5 T 5 1 UM 1 Page 2 of 2 END OF REPORT
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diff --git a/output/text/c73e9714-b13a-4bc5-b0de-665e704c9079.txt b/output/text/c73e9714-b13a-4bc5-b0de-665e704c9079.txt
new file mode 100644
index 0000000000000000000000000000000000000000..789da01be79a834111bc52f59f24ab26a0072bb8
--- /dev/null
+++ b/output/text/c73e9714-b13a-4bc5-b0de-665e704c9079.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TCGA-D5-6533 page 1 / 1 Examination: Histopathological examination. mination No.: Material: Multiple organ resection -- transverse colon with the distal part of the stomach Material collected on: Material received on: Expected time of examination: Clinical diagnosis: Cancer of the transverse colon infiltrating the stomach. Examination performed on Macroscopic description: 30 cm length of the large intestine, with periintestinal fat tissue sized 30 x 8 x 2cm, the omentum sized 30 x 15 cm and part of the stomach sized 11 x 8 x 4 cm. Cauliflower-shaped tumour sized 10 x 8 x 4 cm found in the intestinal mucosa. The lesion surrounds 1o0% of the intestine circumference, 10 cm from the proximal cut line and 10 cm from the distal cut line. The leslon invaded macroscopically through the stomach wall. Microscopic description: Adenocarcinoma tubulopapillare (G1). Infiltratio carcinomatosa parietis intestini crassi totius et parietis ventriculi. Minimum side margin Is 0 cm. Incision lines ends free of neoplastic lesions. Sinus histiocytosis lymphonodorum (No Vlll). Histopathological diagnosis: AdenocarcInoma tusulopapillare coll, Tubulopapillar adenocarcinoma of the colon, (G1; Dukes B; Astler-. Coller B3; pT4b; pN0). Compliance validated CALL YOOR DOCTOR WITH THIS REPORT!
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diff --git a/output/text/c798c414-25a6-421e-84c2-603f9d1a000b.txt b/output/text/c798c414-25a6-421e-84c2-603f9d1a000b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..023660ddc5d5f482623f9db3fc986b433718eb14
--- /dev/null
+++ b/output/text/c798c414-25a6-421e-84c2-603f9d1a000b.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+PREVIOUS DIAGNOSIS INQUIRY PAGE|#: UUID:15A731FD-6889-450D-A028-A01DA759340A TCGA-OR-ASK4-01A-PR Redacted SEX:: F PAT TYPE: ADM DATE: OPER DATE: PROCEDURE: SPHS Right adrenal mass. Two short stitches adrenal vein with thrombus coming out of vein. Iwo long inferior aspect of tumor. One long lateral aspect of tumor. Two double long superior aspect of tumor. Inking according to sarcoma template. Yellow anterior, blue superior, green inferior, red medial, orange lateral, black posterior. PROCEDURE: SPGD 1. "Adrenal gland." Received in formalin in a large container is a 1060 gm (15.5 x 14.5 x 13.5 cm) adrenal gland with attached partially disrupted vessel oriented as above. The gland is surrounded by a thin membranous capsule and an 8.0 x 6.0 x 1.3 cm segment of fibroadipose tissue is attached to the inferior surface. The vessel extending from the medial surface is partially disrupted exposing a tunor mass in the vascular lumen. Per the surgeon, this does not represent a real margin as the tumor mass extended upwards towards the atrium. Inking as follows: Yellow anterior, blue superior, green inferior, red medial, orange lateral, black posterior.' Sectioning reveals a tan parenchyma that is focally hemorrhagic and largely necrotic extending the entire dimension of the gland. A central area of yellow discoloration is noted, 3.5 x 1.0 cm, near the center of the specimen. No lymph nodes are present within the attached fibroadipose tissue. 1A-8. Representative sections of tumor to inferior margin. 1C-D. Representative sections of tumor to anterior margin. 1E-F. Representative sections of tumor to superior margin. 1G-H. Representative section of tumor to medial margin. 1I-J. Representative sections of tumor to posterior margin. 1K-L. Representative section of tumor to lateral margin. 1M-N. Representative section of tumor in areas of yellow discoloration. 10. Representative sections of tumor within attached vessel. Photographs taken.. TcD-o-3 PROCEDURE: SPMI iarcinomc,ao^aal lortex 8370/3 ADRENOCORTICAL CARCINOMA Site: Adrenad Claud,cor+ex Jumor size: 15.5 x 14.5 x 13.5 cm. C 74 Z Tunor Weight: 1060 grams. tS,|3o/13 Capsular Invasion: No.
+
+--- Page 2 ---
+PREVIOUS DIAGNOSIS INQUIRY PAGE #: 2 SEX BIRTHDATE: F PAT TYPE: ADM DATE: OPER DATE: Vascular Invasion: Yes.. Surgical Margins: Vascular margin positive. Peripheral margin negative.. Necrosis: Yes. Mitatic Rate:. 2 per 50 high power field.. Grade: Low. Lymph nodes status: Unknown. Extra-adrenal extension: Yes (large vessel). Stage: T4 NX PROCEDURE: SPDX 1. Adrenal gland, resection: Lox-grade adrenocortical carcinoma (15.5 cm and 1060 grams) with invasion of adjacent large vessels (stage T4). Please see. TEMPLATE for details. and interpreted'tne"smdes from this case.. ** END OF PREVIOUS DIAGNOSIS INQUIRY **
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diff --git a/output/text/c7999d91-c536-42d9-8c0c-68f054598620.txt b/output/text/c7999d91-c536-42d9-8c0c-68f054598620.txt
new file mode 100644
index 0000000000000000000000000000000000000000..cd300cc6ae1b8c0adeb8b3ed256f14fc12e9c4a6
--- /dev/null
+++ b/output/text/c7999d91-c536-42d9-8c0c-68f054598620.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+1cs-0-3 Carmomn, muumouo 848o/3 SiH: srsstj Nts c50.9 1/28h Pathology Form tofin latuahly Specimen Information CQcF shnid L nnud Muctirs IAC Collected by Date: Time Paft Preserved by: Date: ime: RSPECIMENTYPE (#of sample provided* Frozen Paraffin Block Blood/Serum/Plasma Slide Diseased Normal Diseased Normal Diseased  Normal Diseased  Normal x x Time to LN2 Time to Formalin Time to LN2 4u. min min T min   ARA PATHOLOGICALDESCRIPTIONAAA  Primary Tumor Organ Size Extension of Tumor.  Distance to NAT Lseast cm N7 2 X cm Lymph Nodes Location # Examined # Metastasized Axillg 6 3 Distant Metastasis Organ Detailed Location Size Pathological Staging N 1 M o pT y Stage: ILR Notes: '0UID: 3FCE052-931C-4798-A188-F04A2178A5F6 Redacted DISQUALIFIED mucinous
+
+--- Page 2 ---
+Microscopic Description wwtnxww HistologicPatternw.w Cell Distribution + Structural Pattern + Diffuse Streaming  Mosaic Storiform Necrosis Fibrosis Lymphocytic Infiltration  Palisading  Vascular Invasion  Cystic Degeneration Clusterized  Bleeding Alveolar Formation  Myxoid Change Indian File  Psammoma/Calcification wntCellular Differentiationw Adenomatous Sarcomatous + Lymphomatous  Squamous + Round Cell  Large Cell  Squamoid Cell Glandular cell Fibroblast Small Cell Spindle Cell Cell Stratification  Osteoblast  RS Cell/RS Like  Keratin Secretion Intracyt. Vacuole Lipoblast Inflam. Cell Desmosome  Gland formation  Myoblast  Plasma Cell Pear! Well  Moderate  Poor Cellular Differentiation: wNuclearAppearance 0 I II III Nuclear Atypia:  Aniso Nucleosis + Hyperchromatism +  Nucleolar Prominent Multinucleated Giant Cell + Mitotic Activity + Nuclear Grade: Value Date Result Marker ER Negative Positive  Negative Positive PR Her-2/neu  Negative  Positive  Negative  Positive B-Cell Marker  Negative Positive T-Cell Marker  Negative Positive Other:  Negative  Positive Other: Final Pathology Report Hucinos aeustareiama Histological Diagnosis: Grade: 1( Comments: Date  Pathologist Principal Investigator
+
+--- Page 3 ---
+CONSOLIDATED DIAGNOSTIC pAThOLOgy fORm* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION Diffuse STRUCTURAL PATTERN Streaming Mosaic Necrosis  Storiform Lymphocytic Infiltration X Fibrosis Vascular Invasion Palisading Cystic Degeneration Clusterized  Alveolar Formation Bleeding. Myxoid Change Indian File Psammoma/Calcification 2. Cellular features: Squamous Adenomatous + Sarcomatous Squamoid Cell Glandular cell Lymphomatous x Round Cell Spindle Cell Cell Stratification Large Cell Fibroblast Keratin Small Cell  Secretion 4 Osteoblast  RS Cell/RS Like Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell Pear!  Giand formation Myoblast Otherwise Specified: Plasma Cell D : 80 D9 90 2.Cellular Differentiation: Well Moderately Poor Nuclear Atypia: Nuclear Appearance Aniso Nucleosis 4 Hyperchromatism Nucleolar Prominent N Multinucleated Giant Cell Mitotic Activity Nuclear Grade X Histological Diagnosis Lopiltoorhrp Dseta CUny, Mieiroy type Comments: M,Mr : nse metsfe@ Date Director, Research Pathology PATHOLOGIST STAFF FOR RESEARCH USE ONLYJ. *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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diff --git a/output/text/c7dd4856-6474-4de2-baf1-ea7f496f5701.txt b/output/text/c7dd4856-6474-4de2-baf1-ea7f496f5701.txt
new file mode 100644
index 0000000000000000000000000000000000000000..019138720dab3802c98d9423629bb1cd41b07417
--- /dev/null
+++ b/output/text/c7dd4856-6474-4de2-baf1-ea7f496f5701.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+1CD-0-3 Cacinomh, mfilhufNg ductol, N0s 850of3 SitL; breast,Nos C5o.q FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT Or 1974 UUID:726360CA-181C-4400-82FA-A4C978C4D484 TCGA-A2-A04Q-01A-PR Redacted PATHOLOGY REPORT Patient: Specimen #: FMP/SSN: DOB/Age/Sex: F Race: wHITe Taken: Location: Physician(s) : Received: Reported: * * AMENDED* * SPECIMEN: A: SENTINAL B: RIGHT BREAST TISSUE C: NON SENTINAL LYMPH D: SENTINAL LYMPH NODE FINAL DIAGNOSIS: A. LYMPH NODE, SENTINEL NUMBER ONE, BIOPSY: - ONE LYMPH NODE NEGATIVE FOR TUMOR BY H&E AND IMMUNOHISTOCHEMISTRY. B. BREAST, RIGHD, SIMPLE MASTECTOMY: INFILTRATING DUCTAL CARCINOMA, POORLY-DIFFERENTIATED BY COMBINEDS HISTIOLOGIC CRITERIA. TUMOR SIZE 1.8 CM. ASSOCIATED DUCTAL CARCINOMA IN SITU, NUCLEAR GRADE III WITH NECROSIS AND PROMINENT LYMPHOID INFILTRATE COMPRISING 10-15% OF TUMOR. ESTROGEN RECEPTOR: NEGATIVE IN INFILTRATING AND IN SITU CARCINOMA. PROGESTERONE RECEPTOR: NEGATIVE IN INFILTRATING AND IN SITU CARCINOMA.  HER2 NEU BY IMMUNOHISTOCHEMISTRY: 2+ (WEAKLY POSITIVE).  HER2 NEU BY FISH: NOT AMPLIFIED (1.4).  MARGINS NEGATIVE FOR TUMOR. - NO RESIDUAL PAGET'S DISEASE OR LACTIFEROUS DUCT INVOLVEMENT.  MICROCALCIFICATIONS IN NEOPLASTIC BREAST TISSUE. UNINVOLVED BREAST TISSUE SHOWS FIBROCYSTIC CHANGES AND SCLEROSING ADENOSIS. C. LYMPH NODE, NON SENTINEL, BIOPSY: -ONE BENIGN LYMPH NODE. D. LYMPH NODE, SENTINEL NUMBER TWO, BIOPSY: - ONE LYMPH NODE NEGATIVE FOR TUMOR BY H&E AND IMMUNOHISTOCHEMISTRY. cOMMENT: The above results were reported in I on Estrogen and progesterone receptors were evaluated by immunohistochemical Page 1 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 2 ---
+FOR ORFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: FINAL DIAGNOSIS (continued) : methods. A positive test is defined as easily discernable nuclear staining in more than 5% of the tumor cells. The specimen was evaluated for HER-2/Neu (c-erbB2) overexpression by. immunohistochemical methods (DAko Hercep Test). Staining is interpreted. on a scale of 0 to 3+ with positivity defined as 2+ or greater.  .. with a weakly positive (2+)~Hercep Test are further evaluated by Specimens fluorescence in situ hybridization (Pathvysion FIsh assay) to detect presence or absence of Her-2/neu gene amplification. ** Report Electronicallv Signed Out * CLINICAL DIAGNOSIS AND HISTORY: {None Given} GROSS DESCRIPTION: A. senrineL Received in formalin, labeled with the patient's name, and designated "SENTINEL LYMPH NODE NUMBER ONE" is a specimen consisting of a 2.0 x 1.4 x 1.0 cm lymph node. A small portion was submitted for the. CBcp protocol. 1cins. B. RIghT BReAsr TIssuE Received fresh, labeled with the patient's name, and designated "RIGHT BREAsT TIssuE" is a specimen consisting of a 245.0 gram simple mastectomy, 18.0 cm x 13.5 cm x 3.0 cm in dimension. There is a 15.0 cm x 4.0 cm ellipse of nipple-bearing skin. The deep margin is. inked in black. On sectioning, a i.8 cm tumor is identified in the mid-center portion of the breast. The tumor abuts, but does not grossly involve the deep margin. The remaining tissue is extensively fibrosis with admixed fat. Sections of tumor, grossly normal fibrous breast tissue, and skin harvested for the cBcp protocol; mirror images for Histology are as follows: Slide Key: B1: Tumor(cbcp); B2: Fibrous tissue, 1.0 cm medial to tumor. (CBcp); B3: Fibrous tissue, 2.0 cm medial to tumor(cBcp); B4: Fibrous tissue, 5.0 cm medial to tumor(cbcp); B5: Skin, near medial tip (cacp); Page 2 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 3 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION (cOntinued) : B6: Nipple; B7: Tumor and deep margin; B8-b10: Representative tumor; Bll: Medial upper quadrant; B12: Medial lower quadrant; B13: Lateral lower quadrant;~B14: Lateral upper quadrant. 14cFss.. C. NoN sENTINEL LyMPh Received fresh, labeled with the patient's name, and designated "NON-SENTINEL LYMPH NODE" is a specimen consisting of a 1.5 cm x 0.8 cm x 0.5 cm tan lymph node with a scant amount of attached yellow, lobular adipose tissue. 1cF. D. SENTINEL LyMPH NODE Received fresh, labeled with the patient's name, and designated "SENTINEL LYMPH NODE NUMBER TWO" is a specimen consisting of a 1.4 cm x 0.8 cm x 0.4 cm yellow, white soft tissue fragment with two staples and an unoriented suture.. CA. Page 3 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974S End of Report
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diff --git a/output/text/c7f66797-5326-4c7b-8821-51fca002352b.txt b/output/text/c7f66797-5326-4c7b-8821-51fca002352b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..46e2b831353438ecb4f8c9ad06476fa1b8b06f7a
--- /dev/null
+++ b/output/text/c7f66797-5326-4c7b-8821-51fca002352b.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+/cs-0 -3 Carcin oma mfitrnfN9 vuct snl UUID: 36F6CB19-17FE-47FA-BFCA-3846578C028B mucinous 85a3/3 TCGA-D8-A27E-01A-PR Redacted S1te: breast, Nos c50.9 hr 57/9/u page 1 / 1 Department of Cancer Pathology copy No. 2 Date: Examination: Histopathological examination. Internal invoice No. Cost of diagnostic procedure  Examination No.: Patient: xxx PESEL: XXX Age: Gender: F Material: Partial organ resection -- left breast, inner upper quadrant. Unit in charge: Physician in charge: Material collected on: Material received on: Expected time of examination: 5 working days. Clinical diagnosis: Examination performed on: Macroscopic description: Part of the breast sized 6.6 x 5.3 x 1.9 cm removed together with a skin flap of 5.8 x 3.3 cm, marked typically, with an X-ray image. Tumour in cross section sized 0.9 x 0.8 x 1.7 cm. Location of margins: 0.4 cm to the base; 0.5 cm to the front surface; 1.8 cm to the sternum; 3.7 cm to the axilla; 1.8 cm to the shoulder 2.3 cm, 1.7 cm to the lower edge. Radiogram showing a shadowing of 1.4 x 1.4 cm, skin injected with blue dye. Microscopic description: Carcinoma ductale invasivum partim mucinosum invasivum mammae sinistrae NHG2 (3 + 2 + 1/1 mitoza/10 HPF, visual area diameter: 0.55 mm). Largest lesion dimension 1.7 cm. Normal tissue margines as in the macroscopic description. Surgical specimen texture outside tumour showing mastopathia fibrosa partim lipomatosis. Histopathology Diagnosis: Carcinoma ductale partim mucinosum invasivum mammae sinistrae N1lG2, pTIc. Invasive ductal and in part mucinous carcinoma of the left breast.* dr Compliance validated by: dr
\ No newline at end of file
diff --git a/output/text/c8098f4a-8d2a-4b8a-8ff9-afc266468984.txt b/output/text/c8098f4a-8d2a-4b8a-8ff9-afc266468984.txt
new file mode 100644
index 0000000000000000000000000000000000000000..de0b31a09e412848d5cb8c3d9b1c1e6467763301
--- /dev/null
+++ b/output/text/c8098f4a-8d2a-4b8a-8ff9-afc266468984.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:3E53EDF7-037C-4826-9825-32833B194566 tCgA-V5-AASV-01A-pr Redacted Results Surgical Pathology 7cDo 3 Result Data ACCESSION 807/8 C15.9 Entry Date pS <i1/s/14 Component Results Component Lab Clinical History Esophageal cancer Gross Examination Outside case A: Date of surgery: Number of slides: Received from: Surgical Pathology Division Outside path report received? Yes Material to be returned? Yes Microscopic Examination Microscopic examination is performed. Diagnosis A. "ESOPHAGEAL MASS" (BIOPSY), OUTSIDE CASE, DATE OF PROCEDURE SQUAMOUS CELL CARCINOMA IN SITU AT LEAST, WITH FOCI SUSPICIOUS FOR INVASIVE CARCINOMA. COMMENT : Dr. , has also reviewed this case and concurs.. Comment: I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es).. Electronically signed: Testing Performed By I ah - Abbreviation Name Director Address Valid Date Range Present Lab and Collection Surgical Pathology on Result Information Status Priority Abnormality Source Final result Routine Authorizing Provider Information Name: Fax: Phone: Pager: Criteria Primary Tumor Site Discrepancy HIPAA Discrepancy  Oual/Synchronous Primary se is(circle): Reviewed2/8/42 nitials
\ No newline at end of file
diff --git a/output/text/c80f747d-9ad5-43ed-a69c-19e38f598472.txt b/output/text/c80f747d-9ad5-43ed-a69c-19e38f598472.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4a1908b515456b5bc4363d88deaf52507309327b
--- /dev/null
+++ b/output/text/c80f747d-9ad5-43ed-a69c-19e38f598472.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+I personally informed this natient that a specimen(s) would be collected to be used for research purposes. I reviewed the.  RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the. consent form as a free and voluntary act. A copy of this -... our institution. Clinical Information OSCENEPAANEORMATIONASOSAS HISTORY OF PRESENT ILLNESS Chief Complaints: Ahdomindl nain y brightred blood inthe Lue Symptoms: U ei qhf Wgs Clinical Findings:. Performance Scale (Karnofsky Score):  100 Asymptomatic   80-90 Symptomatic but Fully Ambulatory 60-70 Symptomatic, in bed less than 50% of day  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden.  20-30 Bed Ridden CURRENTMEDICATIONSM MSSSS Drug Dose Route Frequency Date (mm/dd/yyyy) To To / To To / To
+
+--- Page 2 ---
+S PASTMEDICAL HISTORYPEMS Diagnosis/Disease/Disorder/Injury  Diagnosis Date Treatment Status ESOCIALHISTORY Occupation: Environmental Hazards: Smoking History Current Status Type Packs/day Duration When Quit  YES PPNO (yrs) (yr) Alcohol Consumption Current Status Type Drinks/day Duration When Quit YES #NO (yrs) (yr) Drug Use Current Status TYPE Frequency Duration When Quit  YES NO (yrs) (yr) SFAMILYMEDICALHISTORYS Relative Diagnosis Age of Diagnosis LAB DATA Date Test Result Date Test Result CEA  Negative  Positive:  Positive: CA 15-3  Negative  Positive: Hep B Negative CA 19-9   Negative Hep C Negative  Positive:  Positive: PSA  Negative  Positive:   Negative  Positive: AFP Other: Other:  Negative  Negative  Positive:  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+SMEDIAGNOSTICSTUDIESS Study Results Date Ultrasound X-Ray CT EndoscopyyA Gumeay W as Sourd in the Sigonwio colen MRI Biopsy Preoperative Clinical Diagnosis Location of Suspected Involved Lymph Nodes Location of Suspected Distant Metastasis Clinical Staging D-to af Diaanosis T3 Nc MC Stage:1 Treatment Information SSSURGICALTREATMENTSSESSSNS Procedure Date of Procedure H e mi wl eetxs Primary Tumor Organ Detailed Location Size fx 3 x Celep canCeR 8jqmei4 cm Extension of Tumor- Lymph Nodes Description Location of Lymph Nodes # of Lymph Nodes Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Organ Detailed Location Size Surgical Staging T 3 No. mo Stage: NEOADJUVENT THERAPY ChemoRadiation Immuno HormonalorMolecular Dose Route Frequency Date (mm/dd/yyyy) Drug/Treatment / To To To / / / To / / / To / 3
+
+--- Page 4 ---
+Pathology Form Specimen Information  SPECIMEN TYPE (#of samples provided) Frozen Paraffin Block  Blood/Serum/Plasma Slide Diseased  Normal Diseased Normal Diseased  Normal Diseased Normal 2 Z 2 Time to LN2 Time to Formalin Time to LN2 min IL min min S PATHOLOGICAL DESCRIPTION ZSTSE Primary Tumor Organ Size Extension of Tumor Distance to NAT Co len canceR x 3 x Sgone'e! 6 cm cm Lymph Nodes Location # Examined # Metastasized Distant Metastasis Organ Detailed Location Size Pathological Staging N o mo pT 3 Stage: 1 Notes: 4
+
+--- Page 5 ---
+Microscopic Description s Histological Pattern a Cell Distribution + Structural Pattern +  Diffuse  Streaming  Mosaic  Storiform  Necrosis  Fibrosis Lymphocytic Infiltration.  Palisading Vascular Invasion  Cystic Degeneration Clusterized  Bleeding Alveolar Formation  Myxoid Change  Indian File  Psammoma/Calcification aCellular Differentiation Squamous + Adenomatous + Sarcomatous + Lymphomatous  Squamoid Cell Glandular cell Round Cell  Large Cell  Spindle Cell Cell Stratification Fibroblast Small Cell  Keratin Secretion Osteoblast RS Cell/RS Like  Desmosome Intracyt. Vacuole Lipoblast  Inflam. Cell  Pear!  Gland formation X Myoblast  Plasma Cell Cellular Differentiation: Well Moderate 1 Poor Nuclear Appearances a Nuclear Atypia: 0 I II III Y Aniso Nucleosis Hyperchromatism  Nucleolar Prominent x  Multinucleated Giant Cell  Mitotic Activity Nuclear Grade: IHData Marker Result Value Date ER  Negative   Positive PR  Negative  Positive Her-2/neu  Negative  Positive B-Cell Marker  Negative   Positive T-Cell Marker  Negative  Positive Other:  Negative   Positive Other: . Negative   Positive Final Pathology Report <il/ous adenocakcincm2 0 the 8'qmce)co(en Histological Diagnosis: RilLerentia'eo Grade:L Iuddlerale Comments:
+
+--- Page 6 ---
+Histological pattern: CELL DISTRIBUTION Diffuse STRUCTURAL PATTERN +I-  Mosaic XStreaming.  Storiform  Necrosis X Fibrosis Lymphocytic Infiltration Vascular Invasion Palisading Cystic Degeneration Clusterized Alveolar Formation Bleeding  Myxoid Change Indian File Psammoma/Calcification 2. Cellular features:  Squamous +-Adenomatous +  Sarcomatous  Squamoid Cell + Lymphomatous Glandular cel! Y Round Cell  Large Cell Spindle Cell  Cell Stratification Fibroblast Small Cell  Keratin Secretion Osteoblast  RS Cell/RS Like  Desmosome Intracyt. Vacuole Lipoblast Inflam. Cell Pear!  Gland formation Myoblast Plasma Cell Otherwise Specified: D1 SU D2 6o D?50Z Der. 2. Cellular Differentiation: Well  Moderately Poor Nuclear Atypia: Nuclear Appearance  Aniso Nucleosis Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity Nuclear Grade C Histological Diagnosis:_
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diff --git a/output/text/c8122bb9-7894-4360-9ffd-1700bd4bc69a.txt b/output/text/c8122bb9-7894-4360-9ffd-1700bd4bc69a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1367c7e0ab002fcb674b7ea8afd469b710d36db0
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+UUID:C8653D2E-3A8C-4C3B-8638-9BC503E7EBC1 TCGA-UW-A7GG-01Z-PR Redacted Diagnosis: Kidney, right, nephrectomy. - Chromophobe renal cell carcinoma, nuclear grade 3, maximum tumor size 10 cm, tumor confined to kidney with negative surgical margins. and no evidence of involvement of the renal artery, renal vein or ureter. Comment: Drs. and have additionally reviewed this case and concur with. the diagnosis of the chromophobe renal cell carcinoma, nuclear grade 3. LCD-O 3 Coreinons,Nenal ceQL ChLomphobe tyee 8317l 3 Clinical History: RKiolney NOS The patient has a right renal mass. Sst C64.9 A 9124|I3 Gross Description: Received is one appropriately labeled container additionally labeled "right renal mass." Specimen fixation: formalin Type of specimen: radical nephrectomy Size and weight of specimen: 10.0 cm superior to inferior, 14 cm medial to lateral, 7 cm anterior to posterior; 570 grams. Presence/absence of adrenal gland: absent Tumor description: the tumor is a globoid, well circumscribed by a. pseudocapsule, hilar, nodular lesion which on cut surface is softened with yellow/tan color and focal hemorrhage; no central scars are grossly identified Tumor size: 10 x 8 x 7 cm Presence/absence of multicentricity: absent Confinement/Non-confinement to kidney: the tumor is confined by the. renal capsule Extent of invasion: Perirenal adipose tissue: tumor does not grossly involve.
+
+--- Page 2 ---
+Renal vein: tumor does not grossly involve Ureter: tumor does not grossly involve Surgical margins: Perirenal adipose tissue: grossly negative Renal vein: grossly negative Renal artery: grossly negative Ureter: grossly negative Description of kidney away from tumor: the renal cortex is atrophied to 0.5 cm; the calyces are mildly dilated; hydro-ureter is absent Lymph nodes (hilar): none identified. Tissue submitted for special investigations: none Comment: The external surface is uniformly inked blue; representative sections are submitted as per block summary. Block Summary: Al - ureteral renal vein and artery resection margins. A2 - tumor interface with renal hilum A3 - tumor interface with perinephric fat A4,A5 - representative sections of tumor A6,A7 - representative sections of non-tumorous kidney Light Microscopy: Light microscopic examination is performed by Dr. Histologic tumor type/subtype: chromophobe renal cell carcinoma,. consistent with eosinophil chromophobe type Histologic grade (if applicable): nuclear grade 3 Tumor size (greatest dimension): 10 cm Extent of tumor invasion: Capsular invasion/perirenal adipose tissue: negative Renal vein: negative Ureter: negative Blood vascular: negative Lymphovascular: negative Depth of invasion: not applicable Adjacent organs: not applicable. Anaplasia (applicable only to wilm Tumor):
+
+--- Page 3 ---
+Presence/absence: not applicable. Extent: not applicable Histologic assessment of surgical margins: Perirenal adipose tissue: negative. Renal vein: negative Renal artery: negative Ureter: negative Adrenal gland: not present Lymph nodes: not identified Other significant findings: The tumor consists of a cellular neoplasm without true encapsulation which shows a predominant solid growth pattern with admixed tubular and trabecular patterns as well as interspersed stromal hyaline fibrosis particularly in the central regions of the tumor. The tumor consists of an admixture of larger polygonal cells with well defined cell borders and amphophilic cytoplasm and large numbers of admixed small polygonal cells with eosinophilic cytoplasm. Distinct perinuclear halos are present in many cells. Many nuclei show hyperchromatic. features with markedly irregular nuclear membranes and scattered binucleation. The features are consistent with a chromophobe renal cell carcinoma, eosinophilic type. This case was shown in consultation to Drs. and who concur with the diagnosis of chromophobe renal cell carcinoma, nuclear grade 3..
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diff --git a/output/text/c84bc2bb-c130-43b3-bb1d-73a86e78a138.txt b/output/text/c84bc2bb-c130-43b3-bb1d-73a86e78a138.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0ba5bb609965966061b4079841261cd74a5a8a30
--- /dev/null
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+
+--- Page 1 ---
+UUID:5135A7C0-6CA4-404E-9649-E7B664EDD1B8 Redacted LINICAL DIAGNOSIS: HCC - right posterior segment (S6-7) 6.0 cm sized Specimen : Mass, Surrounding liver tissue. Gross Photo :. GROSS: Specimen status: Fresh Operation: Right hemihepatectomy and cholecystectomy Organs: Liver (17.5 x 11.5 x 9.0 cm, 647.0 gm) Gallbladder (10.3 cm in length, 4.2 cm in diameter, and 0.4 cm in thickness) Lesion: [Liver] A well-definedn large round mass (4.7 x 4.5 x 5.0 cm) Cut surface: Yellow to green, solid and firm mass without necrosis Gross type: HCC: Expanding nodular A well-defined small multinodular mass (1.3 x 0.9 x 0.5 cm) Cut surface: Yellowish tan, solid and firm mass without necrosis Gross type:. HCC: Multinodular confluent Resection margin: Not involved grossly (safety margin: 0.3 cm) Others: Satellite nodule: Yes IcDO 3 Remaining parenchyma: Pre-cirrhotic (stage 3) [Gallbladder] arcincma, hepatoe llulsr NOS Multiple polyps with stone (0.7 x 0.6 x 0.6 cm) 8i7013 Representative sections submitted. Sih: duer CQa0 Gross photo: Present Blocks S >5koJ14y TB,T1-4, large tumor mass x 5 T5, separate nodule x 1 L,NB, liver parenchyma x 2 RM, resection margin x 1 GB, gallbladder x 1 MICROSCOPIC: Hepatocellular carcinoma: The worst differentiation III The major differentiation II Histologic type: Trabecular Cell type: Hepatic Fatty change: Yes (10-30 %) Fibrous capsule formation: Yes Capsular infiltration: No Septum formation: Yes Surgical resection margin invasion: No/ safety margin (0.3 cm).
+
+--- Page 2 ---
+Serosal invasion: No Portal vein invasion: No Microvessel invasion: Yes Intrahepatic metastasis: Unknown Multicentric occurrence: Present NOT reported. Gross: Liver, ectomy, hepatocellular carcinoma, well differentiated. T56000, P10, M81703, well differentiated Gallbladder, ectomy, autolysis, cholesterol polyps, cholelithiasis T57000, P10, M54001, cholesterol polyps, M30011 Lymph node, pericystic, biopsy, reactive hyperplasia. T08000, pericystic, P50, M72200 DIAGNOSIS: Liver, right hemihepatectomy: Hepatocellular carcinoma (Edmondson-steiner grade 2),.  well-differentiated Gallbladder, cholecystectomy: Autolysis Cholesterol polyps Cholelithiasise Lymph node, pericystic, biopsy: Reactive hyperplasia (0/1) Suggestion : hv 1f13/14
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diff --git a/output/text/c856de2a-a242-4040-b636-05bd8bcdf669.txt b/output/text/c856de2a-a242-4040-b636-05bd8bcdf669.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1c213a6199d41d1bfb192493b381ba26b3855fe0
--- /dev/null
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+
+--- Page 1 ---
+UUID:6A981CB0-F551-48B1-AB91-5D5585A7F2820 tcga-S3-aa10-01a-pr  Redacted Page 1 of 4 Surgical Pathology FinalReport Temporary Copy Case: Patlent Collected: IDK Ordered.by. Locatlon. Diagnosis A. RIGHT BREAST, MASTECTOMY: - HIGH-GRADE INVASIVE DUCTAL CARCINOMA; SEE SYNOPTIC REPORTS - NEGATIVE MARGINS - SKIN AND NIPPLE WITHOUT SIGNIFICANT PATHOLOGIC ABNORMALITYS - FOUR LYMPH NODES, NEGATIVE FOR TUMOR (0/4); SEE SPECIAL STAINS IcD-0-3 (Electronic signature) J 850J3 Verified: CACE Synoptic Report TUMOR SIZE: SIZE OF LARGEST INVASIVE CARCINOMA: Huast, wypn-sutir Greatest dimension of largest focus of invasion over 0.1 cm: 2.5 cm. Ruadrant C60.4 Additional dimensions: 2.5 x 1.5 cm TUMOR FOCALITY: 4O x/24|4 Single focus of invasive carcinoma MACROSCOPIC AND MICROSCOPIC EXTENT OF TUMOR: Skin: Invasive carcinoma does not invade into the dermis or epidermis Nipple: DCIS does not involve the nipple epidermis Skeletal Muscle: Skeletal muscle is present and is free of carcinoma. DUCTAL CARCINOMA IN SITU (DCIS): No DCIS is present LOBULAR CARCINOMA IN SITU (LCIS): Not identified HISTOLOGIC TYPE OF INVASIVE CARCINOMA: Invasive ductal carcinoma (no special type or not otherwise specified). GLANDULAR (ACINAR)/TUBULAR DIFFERENTIATION: Score 3: <10% of tumor area forming glandular/tubular structures NUCLEAR PLEOMORPHISM: Score 3: Vesicular nuclei, often with prominent nucleoli, exhibiting marked variation in size and shape,  occasionally with very large and bizarre forms MITOTIC COUNT: Score 3 Number of mitoses per 10 high-power fields: 88 Diameter of microscope field: 0.55 mm OVERALL GRADE: Grade 3: scores of 8 or 9 MARGINS: Margins uninvolved by invasive carcinoma. Distance from anterior margin: 4.0 mm Distance from posterior margin: 2.0 mm TREATMENT EFFECT: RESPONSE TO PRESURGICAL THERAPY: IN THE BREAST:  No known presurgical therapy TREATMENT EFFECT: RESPONSE TO PRESURGICAL THERAPY: IN THE LYMPH NODES:  No known presurgical therapy LYMPH-VASCULAR INVASION: Not identified.
+
+--- Page 2 ---
+Page 2 of 4 SurgicalPathology Final Report Temporary Copy Case: Collected:: ID Ordered by:  Location: DERMAL LYMPH-VASCULAR INVASION: Not identified LYMPH NODES: Total number of lymph nodes examined (sentinel and nonsentinel): 4 Number of lymph nodes with macrometastases (>0.2 cm): 0 Number of lymph nodes with micrometastases (>0.2 mm to 0.2 cm and/or >200 cells): 0 METHOD OF EVALUATION OF SENTINAL LYMPH NODES: Hematoxylin and eosin (H&E), one level Immunohistochemistry PRIMARY TUMOR (INVASIVE CARCINOMA (pT):  pT2: Tumor >20 mm but less than or equal to 50 mm in greatest dimension REGIONAL LYMPH NODES (pN): pN0: No regional lymph node metastasis identified histologically DISTANT METASTASIS (M): Not applicable ADDITIONALPATHOLOGIC FINDINGS Benign breast with calcifications ESTROGEN RECEPTOR: Performed on this specimen. No immunoreactive tumor cells present PROGESTERONE RECEPTOR: Performed on this specimen No immunoreactive tumor cells present HER2/NEU IMMUNOPEROXIDASE STUDIES: Performed on this specimen. Negative (Score 0) MICROCALCIFICATIONS: Present in non-neoplastic tissue Specimen Source A RT Breast and Axillary Contents Clinical Information None PRE-OP DIAGNOSIS: Right breast CA POST-OP DIAGNOSIS: Same TYPE OF PROCEDURE: Right modified mastectomy Gross Description The specimen is labeled "RIGHT BREAST AND AXILLARY CONTENTS" and is received unfixed (the specimen is in formalin for more than 6 hours and less than 48 hours). It consists of a 420 g right mastectomy with axillary contents weighing 420 g measuring 18 x 10 x 3.0 cm. The axillary content measures 6.0 x 5.5 x 3.0. cm. The nipple is unremarkable measures l.3 x 1.3 cm in maximum dimensions. Solar is unremarkable. The left. fascia is smooth and glistening. The anterior margin is inked red and the deep posterior margin is inked black. On sectioning, there is a well-circumscribed lobulated focally hemorrhagic pink-tan mass measuring 2.5 x 2.5 x 1.5 cm. The mass is close to the deep posterior margin in the outer quadrant close to the axillary contents. The mass is 0.7 cm from the anterior margin and approximately 12 cm from the nipple. On further sectioning the. breast parenchyma is nodular, there are no other lesions grossly identified. There are four fatty lymph nodes.
+
+--- Page 3 ---
+Page 3 of 4 SurgicalPathology Final Report Temporary Copy Case Patient. Collected ID Ordered bys Location: ranging from 0.5-2.0 cm in maximum dimensions. Representative sections are submitted. Section Key: Al - A2 tumor markers with deep margin A3 - tumor A4 - nipple and skin A5 - anterior margin close to mass A6 - upper inner quadrant A7 - lower inner quadrant A8 - random sections from central breast A9 - upper outer quadrant A10 - lower outer quadrant A11 - one lymph node bisected A12 - one lymph node bisected A13 - two lymph nodes Time specimen was removed from the patient (procedure time): Time specimen was placed in formalin: Ischemic time: 1 hour 20 minutes Dictated by: Special Stains / Slides IMMUNOHISTOCHEMICAL EVALUATION OF ESTROGEN RECEPTORS, PROGESTERONE RECEPTORS, AND HER-2NEU IN INVASIVE MAMMARY CARCINOMA . ESTROGEN RECEPTORS: 0 %, NEGATIVE. PROGESTERONE RECEPTORS: 0 %, NEGATIVE. STAINING INTENSITY:  HER-2NEU: SCORE 0, NEGATIVE. Immunohistochemical studies were performed on formalin fixed paraffin embedded tissue (Block A2) using the following monoclonal antibodies: Estrogen receptor (Clone SP1), Progesterone receptor(Clone 1E2) and Her-2neu( Clone 4B5); control sections for HER-2Neu are provided within a kit (score 0 MCF-7, score 1+ T-47D, score 2+ MDA-MB-453, score 3+ BT-474). Detection system used: polymer. Primary antibodies, reagents and control sections for HER-2neu are all provided by. All controls show appropriate reactivity. Reactivity of Estrogen and Progesterone receptors is determined based on the percentage of positively stained nuclei of tumor cells. Reference values (CAP accreditation program checklist 2010 and guidelines on webpage): Positive: nuclear staining in 1% or greater than 1% of invasive carcinoma cells. Negative : nuclear staining in less than 1% of invasive carcinoma cells. Staining intensity: is reported as weak, moderate or strong
+
+--- Page 4 ---
+Page 4 of 4 Surgical Pathology Final Repon Temporary Copy Case: Patlent Collected.. ID: Location. Ordered by HER-2neu reactivity is reported applying the CAP scoring guidelines (CAP accreditation program checklist 2010 and guidelines on webpage): Score 0 = Negative: No immunoreactivity, or faint weak immunoreactivity in <10% of tumor cells but only a portion of the membrane is positive.. Score 1 -- Negative: Faint weak immunoreactivity in 10% or >10% of tumor cells but only a portion of the membrane is positive. Score 2+ -- Equivocal: Weak to moderate complete membrane immunoreactivity in >10% of tumor cells or circumferential intense membrane staining in <30% of cells. Score 3+ = Positive: More than 30% of the tumor cells must show circumferential intense and uniform membrane staining. A homogeneous (chicken wire) pattern should be present. Equivocal results for HER-2neu (Score 2+) will be subsequently followed by a reflex dual-color ISH testing. Additional immunohistochemical studies fpr AE1/AE3 were performed on formalin fixed, paraffin-embedded tissue (Blocks Al1-13) with adequate positive and negative control sections. All stains were negative. The performance characteristics of these antibodies were determined by the . They have not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. These tests are used for clinical. purposes. They should not be regarded as investigational or for research. This laboratory is certificd under the Clinical Laboratory. Improvement Amendments of 1988 (CLIA-88) as qualified to perform high-complexity clinical laboratory testing. Tissue Code
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diff --git a/output/text/c89b96f7-92fd-4b27-b99c-2e77930f9066.txt b/output/text/c89b96f7-92fd-4b27-b99c-2e77930f9066.txt
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index 0000000000000000000000000000000000000000..da067052b67a72411185b03a50c43de4d31580a8
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+160 -0- 3 Hhchjy: Cawinonn, UriHhulr,NOS 8i20|3 lw 8-606C-41A9-B050-E115834A7616 TCGA-BL-A13J-01A-PR Redacted 1H Sits. b1addw,N0s Cb7-9 SPECIMEN CQCF : b1ucdu wnll, postericr Cb74 A. Right distal ureter B. Left distal ureter C. Left pelvic lymph node. D.  Bladder and prostate E. Right pelvic nodes F. Left pelvic nodes G. Appendix H. Sigmoid colon CLINICAL NOTES CLINICAL HISTORY: Bladder cancer. PRE-OP DIAGNOSIS: Bladder cancer. FROZEN SECTION DIAGNOSIS A) Ureter, right distal, excision - Inflammation with variable epithelial atypia. B) Ureter, left distal, excision - Inflammation with variable epithelial atypia. C) Lymph node, left pelvic, excision - Metastatic carcinoma. GROSS DESCRIPTION A. Received fresh for frozen section labelled "right distal ureter" is a segment of ureter that measures 0.4 x 0.4 x 0.3 cm in dimension. Tissue is entirely frozen. B. Received fresh for frozen section labelled "left distal ureter" is a segment of ureter that has a dilated lumen and measures 0.8 x 0.7 x 0.3 cm in dimension. Tissue is entirely frozen. C. Received fresh labelled "left pelvic lymph node" is an irregular-shaped fragment of fibroadipose tissue that measures 3.5 1.5 x 1.2 cm in dimension.. Within the tissue, a lymph node is. identified that measures 1.7 cm in dimension. The lymph node is GROSS DESCRIPTION entirely frozen as Fscl and Fsc2.. D. Received fresh and subsequently fixed in formalin. labeled "bladder and prostate" is a 21 x 10 x 6.5 cm. bladder and prostate, which is partially covered with abundant yellow lobular fat. The bladder itself is approximately 8.5 x 7.8 6 cm and the prostate is approximately 35 grams, 4.5 x 3.5 x 3.2 cm. The left ureter is approximately 5 cm x 0.7 cm and is markedly. dilated. The right ureter is approximately 4.5 x 0.5 cm.  There are adhesions on the posterior aspect of the bladder wall in a 4 x 3.5
+
+--- Page 2 ---
+cm area. The right half of the specimen is inked blue and the left posterior aspect of the specimen is inked black. The left anterior aspect of the specimen is inked also blue. The specimen is opened in a Y-shaped incision to show a friable area of tumor in the posterior wall. There is also tumor present in the left lateral wall. This entire area is 6.7 x 6.5 cm. This comes within 5.5 cm of the prostatic urethral margin. There is also a tumor polyp measuring 1 cm in the right anterior part of the wall, which is located 7 cm from the prostatic urethra. The cut surface of the polyp showed no discrete invasion through the wall; however, the cut surface of the large tumor mass shows invasion through the left lateral wall and through the posterior wall. This comes within 0.1 cm of the radial margin. No discrete tumor is grossly identified within the left ureter; however, the ureter is markedly dilated up to 0.7 cm in diameter. No lymph nodes are grossly identified in the surrounding fat. The seminal vesicles average 3.5 x 1.5 x 0.8 cm. The vasa deferentia could not be grossly identified.. Representative sections of the specimen are submitted following further fixation. BLOcK suMMARy: 1 - apical bladder margin with prostatic urethral margin en face; 2-3 - prostatic urethra, with full-thickness prostate composite slice; 4 - bilateral ureteral margins and representative seminal vesicles; 5 - representative anterior bladder; 6 - representative dome of bladder to tumor, GROSS DESCRIPTION full-thickness; 7 - trigone full-thickness; 8 - representative section of bladder to posterior margin full-thickness; 9 - right side bladder to ureteral orifice; 10 - right posterior bladder full-thickness; 11-12 - left side full-thickness composite bladder with ureteral orifice; 13 - possible representative left side vas deferens within tumor and representative section of right-side seminal vesicle; 14 - additional representative section of full-thickness tumor to posterior wall; 15 - entire right-sided polyp full-thickness; 16-22 - representative section of prostate as follows: Block 1 - full-thickness composite; 17-18 - full-thickness composite; 19-20 - full-thickness composite; 21-22 - full-thickness composite. RS-22. E. Received fresh, subsequently fixed in formalin labeled "right pelvic nodes" is a 4.5 x 3.2 x 2.0 cm aggregate of yellow lobular fatty tissue. Lymph nodes are grossly identified which range from 0.5 cm to 3.5 cm in greatest dimension. The lymph nodes are entirely submitted as follows:. BLOcK suMMARy: 1 - three possible lymph nodes; 2 - one possible lymph node bisected;" 3-4 - one possible lymph node bisected, one-half in each..
+
+--- Page 3 ---
+F. Received fresh, subsequently fixed in formalin. labeled "left pelvic lymph nodes" is 4.5 x 4.0 x 2.2. The. specimen is palpated to identify multiple lymph nodes which range from 1.2 cm to 7.5 cm in greatest dimension. The lymph nodes are entirely submitted as follows: BLOcK suMMARy: 1 - three possible lymph nodes; 2-5 - one possible lymph node sectioned. G. Received fresh, subsequently fixed in formalin. labeled "appendix" is a 5.5 x 0.5 cm appendix which is partially covered. with pink-tan smooth glistening serosa and yellow lobular fat.  The specimen is sectioned to show an intact wall with an average thickness of 0.3 cm. The lumen ranges from pinpoint to 0.2 cm. No other discrete gross lesions are identified. The appendix is GROSS DESCRIPTION entirely submitted in two cassettes with the proximal end inked (fat and staples retained). As-2. H. Received fresh subsequently fixed in formalin labeled "sigmoid colon" is a 14.5 cm. long portion of colon which is opened at one end inked blue and the opposite end is stapled and is inked black. The serosa of the specimen is pink tan, smooth and glistening and is partially covered with abundant yellow lobular fat. There are a few adhesions on the specimen, however, no hemorrhage or fibrinous exudate is grossly identified. The. specimen is opened to show pink tan smooth glistening mucosa with an average circumference of 4.5 cm. There is a 0.3 cm. sessile polyp which is located on a fold, 4.5 cm. to the blue inked margin. A few diverticula are grossly identified and show no gross evidence of submucosal abscesses or perforation present. Representative sections of the specimen are submitted as follows:. BLock summARy: 1 - representative luminal margins; 2 - sessile polyp; 3 - representative normal; 4 through 8 - representative sections of the remainder of the specimen including diverticula. RS-8 MICROSCOPIC DESCRIPTION Histologic type:. Urothelial carcinoma. Histologic grade:.  High grade. Associated epithelial lesions: Papillary urothelial carcinoma, high
+
+--- Page 4 ---
+grade and carcinoma in situ. Primary tumor (pT): Tumor invades through the full thickness of the wall into the adjacent adipose tissue and invades into prostatic stroma from the prostatic urethra, pT4.. Margins of resection: Tumor extends to the soft tissue margin of excision on the posterior surface of the bladder and is present at MICROSCOPIC DESCRIPTION the prostatic urethral margin.. Regional lymph nodes (pN): 2 of 11 lymph nodes positive for metastatic carcinoma (2/11), pN2. Distant metastasis (pM): pMx Vascular invasion: Present. Other findings: Perineural invasion by tumor is present. Tumor is present surrounding the left side vas deferens. The prostatic urethra shows changes of carcinoma in situ and invasive urothelial carcinoma extending from glands into prostatic stroma. The prostate shows glandular and stromal hyperplasia. 14x3, 15x1, 3x3, 5xl, 4x3, 2x1 DIAGNOSIS '; A. Urethra, right distal, excision - Focal urothelial atypia with associated inflammation. B. Urethra, left distal, excision - Focal urothelial atypia with associated inflammation. C. Lymph node, left pelvic, excision - 1 lymph node positive for metastatic urothelial carcinoma (l/l). The size of the metastasis is l.7 cm. in greatest dimension. Extracapsular extension by tumor is identified.. D. Bladder and prostate, excision - Invasive poorly differentiated urothelial carcinoma involving the bladder and prostatic urethra. Tumor extends through the full' thickness of the wall into the adjacent soft tissue and is present at the posterior soft tissue margin of excision. Tumor extends to the prostatic urethral margin of excision. Tumor is present within the prostatic urethra and invasive urothelial carcinoma is present in prostatic stroma (see tumor. characteristics in the prostatectomy template).. E. Lymph nodes, right pelvic, excision - 1 of 4 lymph nodes positive
+
+--- Page 5 ---
+DIAGNOSIS for metastatic carcinoma (1/4). F. Lymph nodes, left pelvic, excision - 6 lymph nodes negative for metastatic carcinoma (0/6). G. Appendix, appendectomy - No significant histopathologic. abnormality. H. Colon, sigmoid, excision - Diverticulosis with diverticulitis with focal changes consistent with chronic diverticulitis with associated fibrosis in the pericolonic adipose tissue with inflammation and reactive changes.. Adenomatous polyp. The margins of excision do not show adenomatous change.. (Electronic Signature) End Of Report
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diff --git a/output/text/c9108525-9dc2-40a1-bf31-8200484d4f40.txt b/output/text/c9108525-9dc2-40a1-bf31-8200484d4f40.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3ba14f6dcc93d6fcbda7c49d1a2e62965709d57d
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+--- Page 1 ---
+UUID:9BDF3D5C-8203-4F43-9BE5-8F1F278C124B Redacted TSS Patient ID: Surgical Date: Gross Description: Tumor is located in Small intestine, moderately-margin, soft, solid, or yellow, gray surface with 6x5x3cm in size. Three mesenteric masses are 0.5x2cm. Microscopic Description: Mucosa is ulcerated. Tumor cells arrange in diffuse replace benign tissue. The tumor cells are composed of large transformed lymphoid cells with hyperchromatic enlarged nuclei. Tumor cells are oval or round in shape with defined cytoplasm. Nucleoli is single or multiple. Mitotic figures are commnon. Diagnosis Details: Large B-cell diffuse lymphoma Comments: Formatted Path Reports: Small intestine tumor checklist Diagnosis: Diffuse large B-cell lymphoma of the small intestine IHC Results: CD20(+), CD3(-), CKAE1/AE3(-) Extranodal involvement : Small intestine, mesenteric lymph node Neo-adjuvant treatment: No Comments: None tD-o-3 rehsmo) NO S Sjee Darg B-eell 9680/3 Site: Small ntestiie NOS C17.4 3o|13 W033h
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diff --git a/output/text/c922889b-fb69-44a2-98a2-7eb39c82f8b3.txt b/output/text/c922889b-fb69-44a2-98a2-7eb39c82f8b3.txt
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index 0000000000000000000000000000000000000000..a5b253b1e85c14ec23fd7128fbcce174ac18c91a
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+
+--- Page 1 ---
+Patient Name: Accession #: Med. Rec. #: Date of Procedure DOB: Date of Receipt Gender: Date of Ropor Ref. Physician: Account #: Patient Address: Billing Type: Additional Copy lo: Ref. Source: Cllnical Diagnosis & History: ith right renat mass.. Specimens Submitted: 1 KIDNEY. RIGHT. PARTIAL NEPHRECTOMY 2: LYMPH NODES, PRECAVAL AND PARACAVA 3: RIGHT ADRENAL GLAND AND SUPRAHILAR LYMPH NODE. EXCISION DIAGNOSIS: 1. KIDNEY, RIGHT,  PARTIAL NEPHRECTOMY Tumor Type: Ronal coll carcinona - Papillary type Low grade Tumor Size: Greatesl diameter is 17 cm. Local Invasion (lor renal cortical lypos): Not Identified Renal Vein Invasion.. Not identified Surgical Margins: Free of tumor Non-Neoplastic Kidney: Unremarkable Adrenal Gland Seo part 3 Lymph Nodes: See part 2 Staging for renal coll carcinoma/oncocytoma:  pT2 Tumor >7.0 cm in greatest dimension limited to the kidney Comment: The immunohistochemical stains show that the renal cell carcinoma, papillary type is posiive for CK7, racemase. focally positive for CA-9 and negative for CD10 supporting the diagnosis.  LYMPH NODES, PRECAVAL AND PARACAVAL, EXCISION 2. Lymph Nodes: Nol involved Page 1 of 3
+
+--- Page 2 ---
+Number of nodes examined:5 3. RIGHT ADRENAL GLAND AND SUPRAHILAR LYMPH NODE. EXCISION Benign adrenal gland IAHIEST THAT THE ABOVE OIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (ANDIOR QTHER MATERIAL), AND THAT IHAVE REVIEWEDANDAPPROVEDTHIS REPORT. 'Specia! Studies: Resull Special Stain. Comment RECUT RECUT CK7 RACEMASE CD10 VIMEN NEG CONT IMM RECUT Gross Description: 1). Tho specinon is recoived Iresh labeted "right kidney" and consists of a kidnoy with atlached uroter. ronal vessels and perinephric fat weighing 2 g in total. The kidney measures 22 x 15 x 11 cm. The attached ureter measures 2.5 cm in length and 0.3 cm in diamoter The allached renal vein measures 1.3 cm in longth and 1.1 cm in dianeter. Tho renal vossels and ureter margins are grossly unremarkabte. An adrenal gland is not identifiod. The kidney is inked black and bivalved to reveal a large cystic tunor measuring 17 x 11 x 8 cm, involving the upper pole of the cortex and is filled with dark brown necrotic lluid, and yellow-brown, necrotic lissue. The tumor is 5 cm from the uroter margin. Sections through the remainder of tho kidney roveal a pink brown parenchyma, with a well-defined cortico-medullary junction. The cortex measures 0.7 cm and the calyces appear. normal. No lymph nodes are identified in the perinephric fat. Tho specimen is photographed. Represontalivo sections are submitted Summary ol sections: UVM -- ureteral and vesset margins .- lumor TSF -- tumor with sinus fat TK -- lumor with adjacent kidney RP -- renal pelvis represenlative sections. K -- represontalive sections kidney 2). The specimen is received in formalin, labeled "precaval and paracaval lymph nodes " and consists of multiple pink tan firm tymph nodes ranging Irom 1 to 2 cm in greatost dimonsion. All identifiod lymph nodes are submitted. Summary of soctions: LN -- lymph nodes Page 2 of 3
+
+--- Page 3 ---
+SURGICAL PATHOLOGY REPON 3). The specimen is received in formalin, labeled "right adrenal gland and suprahilar lymph node" and consists of an irregular. shaped fragment of yellow lobulaled adipose lissue measuring 5.5 x 4 x 2.5 cm.  Seclioning shows a yellow-tan adrenal gland measuring 4.5 x 1.7 x 1 cm and weighing 7 g. Sectioning shows unremarkable cortex and medulla.Grossly no lymph node is. identlied. Summary ol soctions: U-undesignated. Summary of Sections: Part 1: KIDNEY, RIGHT. PARTIAL NEPHRECTOMY Block Sect. Site PCs 2 k 2 2 rp N4 4 ! 2 ik 2 3 isf 3 1 uvm 1 Part 2: LYMPH NODES, PRECAVAL AND PARACAVAL,EXCISIO Block Soct. Site PCs 2 In 2 Part 3:  RIGHT ADRENAL GLAND AND SUPRAHILAR LYMPH NODE, EXCISION Block Sect. Site PCs 2 2 Page 3 of 3 END OF REPORT
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diff --git a/output/text/c923b5bf-cbaa-4dd4-ac33-2bd8c26228d1.txt b/output/text/c923b5bf-cbaa-4dd4-ac33-2bd8c26228d1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..afe0a3a6874707ac7ac11347c108ea7f619c34e9
--- /dev/null
+++ b/output/text/c923b5bf-cbaa-4dd4-ac33-2bd8c26228d1.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+CGA-AA-3939 Diagnosis: Right hemicolectomy preparation with a colon and cecal carcinoma characterized histologically as a moderately differentiated, colorectal adenocarcinoma, measuring 3 cm in diameter at the widest point. Invasive spread of the tumor within all intestinal walllayers up to the bordering mesocolic fatty tissue.. Aborally to Bauhin's valve, ascending colon with a tubular adenoma measuring 2.3 cm with moderate epithelial dysplasia (synonym: low-grade intraepithelial neoplasia). An isolated section of the appendix displays enduring, slightly florid, chronic appendicitis and distinctive, enduring periappendicitis with resorptive xanthous tissue reaction, clearly as a result of a tumor-related relocation of the appendix ostium. The subserosa of the cecum and the oral section of the ascending colon have evidently progressive and extensive macrophage-rich inflammation in the context of perityphlitis. The stage of tumor is therefore: pT3, pn0, (0/40) L0 v0; G2 R0 + Page 1
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diff --git a/output/text/c934968f-00de-4f4c-a977-0dcd68f2227a.txt b/output/text/c934968f-00de-4f4c-a977-0dcd68f2227a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1fb6e5c1c5599ea5e67effe5b3f64a51a3f34c8f
--- /dev/null
+++ b/output/text/c934968f-00de-4f4c-a977-0dcd68f2227a.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:DA4F1C21-0B25-452C-B8C4-B27ECE0216F5 TCGA-YC-A9TC-01A-PR Redacted Research Gross Description -year-old male, bladder TURB Research Dx Bladder tumor, transurethral resection: Urothelial carcinoma with extensive squamous differentiation. See case summary and comment. CASE SUMMARY FOR URINARY BLADDER BIOPSY AND TRANSURETHRAL RESECTION OFS BLADDER TUMOR (TURBT): Procedure: TURBT Tumor type: Invasive carcinoma Histologic type: Urothelial carcinoma with extensive squamous differentiation Associated epithelial lesions: None identified Histologic grade (WHO/ISUP): High grade Tumor configuration: Solid and papillary Adequacy of material for determining muscularis propria invasion: Muscularis propria present. Lymph-vascular invasion: Present Microscopic tumor extension: Tumor invades muscularis propria Additional pathologic findings: Keratinizing squamous metaplasia, extensive necrosis and. calcification AJCC Staging (7th edition): At least pT2 pNX pM:Not applicable Research QC Original Tumor T1: 90% tumor nuclei 1/3 squamous, 2/3 poorly differentiated; 0% necrosis; 10% normal stroma Re-review/Revised: 80% tumor nuclei 1/3 squamous, 2/3 poorly differentiated; 10% necrosis; 10% normal stroma 7CO-0-3 Normal: C'arenons,ursthulial NCS na 81x6/3 Site YoXadde, NoS Research Specimen Ci79 yJ1117/14 Specimen Process Time Blood draw time: Plasma frozen time: Serum frozen time Buffy coat frozen time: Tissue: Cold ischemia start time: Formalin fixation start time: Frozen start time: Total cold ischemia time: 22 minutes Formalin fixation stop time: Total formalin fixation time: :The specimen has spent greater than 6 and fewer than 72 hours in formalin. Specimen Weight
+
+--- Page 2 ---
+Specimen Size Plasma x 3 Serum x 2 Buffy coat x 1 Cryovials x 1 Normal x 0 Tumor x 1 - 1. 475 mg Metastatic x 0 FFPE x 1 Normal x 0 Tumor x 1 Metastatic x 0 Study Patient Consent Yes
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diff --git a/output/text/c94e9603-ca45-44de-8562-ce4a72b144e7.txt b/output/text/c94e9603-ca45-44de-8562-ce4a72b144e7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c8c148d216ab7bc56ac9a68d7d1f2e34e264a144
--- /dev/null
+++ b/output/text/c94e9603-ca45-44de-8562-ce4a72b144e7.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:C3259BD1-1A2A-40C4-A106-FA2EF02018110 Redacted CGA-AR-A24R-01A-PR Final Diagnosis teast, right, wide local excision: Inyasive Nottingham grade III (of IIIl) ductal carcinoma forming a 1.8 x 1.4 x 1.4 cm mass (AJCC pT1c) with prior needle biopsy tract. Angiolymphatic invasion is present. No ductal carcinoma in situ identified. All surgical margins are free of tumor. The closest margin (deep) is free by 0.3 cm. Lymph nodes, right axillary, dissection: Metastatic adenocarcinoma in multiple (6 of 28) right axillary lymph nodes. Three of the positive lymph nodes are matted and form a 1.4 x 1.2 x 1.2 cm mass with extracapsular extension into soft tissue (AJCC pN2). Her-2/NEU has been ordered on paraffin embedded tissue. /cs-0-3 carcinomu,mfiHtrating duct,Nos 85oo/3 Sin: breust, Nos c50.9. 4/351"
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diff --git a/output/text/c966ab8e-a3b5-41cb-a4c5-a178f80dde77.txt b/output/text/c966ab8e-a3b5-41cb-a4c5-a178f80dde77.txt
new file mode 100644
index 0000000000000000000000000000000000000000..05a2e9502d2aabb6964bea6ac7c75de8f99ea03a
--- /dev/null
+++ b/output/text/c966ab8e-a3b5-41cb-a4c5-a178f80dde77.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:FBF36830-33C4-47CB-ADAB-BAAE334AECBB TCGA-G7-A4TM-01A-PR Redacted SPECIMEN(S): A. PARTIAL RIGHT NEPHRECTOMY CLINICAL HISTORY: ics-0-3 None Given carciomn,/nI ull 83t0/3 PRE-OPERATIVE DIAGNOSIS: Str := Kidny, Nos C44.9 None Given M DIAGNOSIS: A. KIDNEY, RIGHT, PARTIAL NEPHRECTOMY:E - PAPILLARY RENAL CELL CARCINOMA (3.8 X 3.5 X 2.3 CM), TYPE 1 - SURGICAL MARGINS NEGATIVE FOR CARCINOMA - SEE SYNOPTIC REPORT SYNOPTIC REPORT - KIDNEY (PARTIAL OR RADICAL)S Specimens Involved Specimens: A: PARTIAL RIGHT NEPHRECTOMY Specimen Type: Partial nephrectomy Without adrenal gland Laterality: Right Tumor Site: Not specified Focality: Unifocal Tumor Size (largest tumor if multiple): Greatest dimension: 3.8cm Additional dimensions: 3.5cm x 2.3cm Macroscopic Extent of Tumor: Tumor limited to kidney WHO CLASSIFICATION Papillary renal cell carcinoma 8260/3.
+
+--- Page 2 ---
+Histologic Grade (Fuhrman Nuclear Grade): G2: Nuclei slightly irregular, approximately 15 u; nucleoli evident Invasion of Vascular/Lymphatic: Indeterminate. Perinephric Tissue Invasion: Absent Margins: Margins uninvolved by invasive carcinoma. Adrenal Gland: Not present Regional Lymph Nodes: None sampled. Additional Findings:  None identified Pathological Staging (pTNM):pT 1a N X M X Pathological staging is based on the AJCc Cancer Staging Manual, 7th Edition. GROSS DESCRIPTION: A. PARTIAL RIGHT NEPHRECTOMY Received fresh labeled with the patient's identification and designated "partial right nephrectomy" is an intact partial nephrectomy specimen weighing 18 g and measuring 3.8 x 3.5. x 2.3 cm. The parenchymal margin previously inked black, remainder of the specimen-blue. The specimen is sectioned to show a soft white/tan focally hemorrhagic mass with lobulated cut surface, 3.3 x 3 x 2.5 cm, located 0.2 cm from the parenchymal margin. Gross photograph is taken. A portion of the specimen is submitted for tissue procurement. Representatively. submitted: A1-A3: Mass, closest parenchymal margin. A4-A8: Additional sections, mass
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diff --git a/output/text/c96b66bf-2c51-4e44-b1df-8792625a53f2.txt b/output/text/c96b66bf-2c51-4e44-b1df-8792625a53f2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2496ad851c28de6769dbacb45a4f0ba02af00b45
--- /dev/null
+++ b/output/text/c96b66bf-2c51-4e44-b1df-8792625a53f2.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+1cy-0-3 Sit: Srsst Nos C50.9 3 page 1 / 2 Department of Cancer Pathology Copy No. Date: Examinatlon: Histopathological examination. Examinatlon No.: Patient: PESEL: Age: Gender: F Material: Multiple organ resection --feft breast Unit in charge:  Physician in charge: Material collected on: Material received on: Expected time of examination: up to 8 working days Clinical diagnosis: Examination performed on: Results of immunohistochemical examination: Estrogen receptors found in 75% of neoplastic cell nuclel. Progesterone receptors found in 10% of neoplastic cell nuclei. HER2 protein stained with HercepTest" by DAKO. Score = 2+, verification by the FisH method recommended.. Compliance validated by: Examination performed on: Macroscopic description: Left breast sized 17.8 x 11.3 x 4.8 cm removed with axillary tissues sized 9 x 5 x 3 cm. Weight 400 g. Skin flap 21.7 x 9.2 cm in size. Tumour sized 3.9 x 6.6 x 2.8 cm found in the central part, placed 1.4 cm from the upper edge, 0.9 cm from the base and 0.0 cm from the skin. Status after blopsy (test No. Microscopic description: Carcinoma lobulare invasivum (G2 acc. to Elston: 3+2+1; 0 mitoses /10 HPF diam. 0.55 mm) Inflltratio carcinomatosa cutis et mammillae. Glandular tissue showing parenchyma atrophy..  invasive lesions are placed 0.1 cm from the base of the surgical specimen. Axillary lymph nodes: Metastases carcinomatosae in lymphonodo (No xI / XIII). Histopathological diagnosis: (including test No. Ca rei nom alobulare invasivum mammae sinistrae. Invasive lobular carcinoma of the left breast. Metastases carcinomatosae In lymphonodis axillae (x1 / xilt) Cancer metastases in axillary lymph nodes (x1/xII) (NHG2, pT3, pN3a). Compliance validated by: UUID:021DF083-A535-4AD4-9545-189A7BC3E1E6 TCGA-D8-A13N-01A-PR Redacted
+
+--- Page 2 ---
+Examination performed on: Examination: Histopathological examination page 2 / 2 Examination No.: Patient: PESEL: Gender: F Examination performed on: Results of immunohistochemical examination: RESULT OF HER2/neu GENE AMPLIFICATION with the FISH method by Path Vysion HER2 DNA Probe Kit FINAL RESULT: HER-2 GENE AMPLIFICATION NOT FOUND Compliance valldated by'
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diff --git a/output/text/c9709352-62e3-4141-869f-6ab9d2c4a7ae.txt b/output/text/c9709352-62e3-4141-869f-6ab9d2c4a7ae.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0b2a67b9c1e9d5923f953ba59f45b9f99aa1e31a
--- /dev/null
+++ b/output/text/c9709352-62e3-4141-869f-6ab9d2c4a7ae.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+1Cs-0-3 Carcinoma, hepatoclluler, Nos 8110/3 Site Cie: Fvi Ca3.0 Patient Key: Surgical date: REVrsED REpORT (Addendum/Procedure included) TISSUE DESCRIPTION: Al A2 A3 A4 A5 A6 B1 C1 Dl D2 D3 D4 D5 D6 D7 D8 Right lobe liver (1035 grams, 22.7 x 13.8 x 10.6 cm), tissue from the left portal vein (thrombus, 1.8 x 1.5 x 0.4 cm), gallbladder (9.2 x 3.1 x 1.3 cm) and peri-choledochal lymph nodes (together measuring 4.1 x 2.0 x 1.3 cm). DIAGNOSIS: Liver, right lobe, resection: Grade 3 (of 4) hepatocellular carcinoma is identified forming a multinodular mass (l5.3 x 13.2 x 7.6 cm) associated with vascular invasion. There are multiple (7) satellite nodules ranging in size from 0.3 cm to 2.7 cm in greatest dimension. Tumor extends to within 0.1 cm of the surgical resection margin. Tumor thrombus is also present within the vein but the vessel margin is negative. Embolic material and coils also identified.  Assessment of nonneoplastic liver to be reported in an addendum. Soft tissue, left portal vein, excision: Positive for hepatocellular carcinoma. Gallbladder, cholecystectomy: Without diagnostic abnormality. Negative for malignancy. Lymph nodes, peri-choledochal, excision: Multiple (6) peri-choledochal lymph nodes are negative for tumor. ADDENDUM: Non-neoplastic liver shows inactive chronic hepatitis with bridging fibrosis (stage 3), consistent with the patient's known history of chronic hepatitis B. JUID:951E7AF TCGA-DD-A1EH-01A-PR Redacted
+
+--- Page 2 ---
+Pat.ent Patient Key: Surgical date:. REVIsED REpORT (Addendum/Procedure included) TISSUE DESCRIPTION: Al A2 A3 A4 A5 A6 B1 C1 D1 D2 D3 D4 D5 D6 D7 D8 Right lobe liver (1035 grams, 22.7 x 13.8 x 10.6 cm), tissue from the left portal vein (thrombus, 1.8 x 1.5 x 0.4 cm), gallbladder (9.2 x 3.1 x 1.3 cm) and peri-choledochal lymph nodes (together measuring 4.1 x 2.0 x 1.3 cm). DIAGNOSIS: Liver, right lobe, resection: Grade 3 (of 4) hepatocellular carcinoma is identified forming a multinodular mass (15.3 x 13.2 x 7.6 cm) associated with vascular invasion. There are multiple (7) satellite nodules ranging in size from 0.3 cm to 2.7 cm in greatest dimension. Tumor extends to within 0.1 cm of the surgical resection margin. Tumor thrombus is also present within the vein but the vessel margin is negative. Embolic material and coils also identified. Assessment of nonneoplastic liver to be reported in an addendum. Soft tissue, left portal vein, excision: Positive for hepatocellular carcinoma.. Gallbladder, cholecystectomy: Without diagnostic abnormality. Negative for malignancy.. Lymph nodes, peri-choledochal, excision: Multiple (6) peri-choledochal lymph nodes are negative for tumor. ADDENDUM: Non-neoplastic liver shows inactive chronic hepatitis with bridging fibrosis (stage 3), consistent with the patient's known history of chronic hepatitis B.
+
+--- Page 3 ---
+Pahent Liver - Digestive System CAP Approved * Data elements with asterisks are not required for accreditation purposes for the Commission on Cancer. These elements may be clinically important. but are not yet validated or regularly used in patient management.. Alternatively, the necessary data may not be available to the pathologist at the time ot pathologic assessment of this specimen.. LIVER: Resection Patient name: (to be de-identified) Surgical pathology number: MACROSCOPIC Specimen Type  Right lobectomy Extended right lobectomy Medial segmentectomy Left lateral segmentectomy Total left lobectomy Explanted liver Other (specity): Not specified Focality Solitary (specity location): V Multiple (specify location)D +-Cq! Tumor Size It.."em Greatest dimension: I1. *Additional dimensions? ...... cm Cannot be determined (see Comment) MICROSCOPIC Histologic Type  Hepatocellular carcinoma Fibrolamellar hepatocellular carcinoma variant (specity): Combined hepatocellular and cholangiocarcinoma Cholangiocareinoma, intrahepatic Bile duct cystadenocarcinoma Undifferentiated carcinoma Other (specitfy): Carcinoma, type cannot be determined Histologic Grade Not applicable GX: Cannot be assessed GI: Well differentiated GII: Moderately ditferentiated GIV: Undifferentiated/anaplastic Other (specity):
+
+--- Page 4 ---
+Patient Ke Pathologic Staging (pTNM) Primary Tumor (pT) pTX: Cannot be assessed pTO: No evidence ot primary tumor pT I: Solitary tumor with no vascular invasion pT2: Solitary tumor with vascular invasion or multiple tumors none more than 5 cm  pT3: Multiple tumors more than 5 cm or tumor involving a major branch of the portal or hepatie vein(s) pT4: Tumor(s) with direct invasion of adjacent organs other than the gallbladder or perforation of visceral peritoneum Regional Lymph Nodes (pN) pNX: Cannot be assessed pNO: No regional lymph node metastasis pN1: Regional lymph node metastasis Specity: Number examined: Number involved: Distant Metastasis (pM) V pMX: Cannot be assessed pM1: Distant metastasis *Specify site(s), it known: Margins (check all that apply) Parenchymal Margin Cannot be assessed  Uninvolved by invasive carcinoma 1.0 Distanee of invasive careinoma from closest margin:'  mm Specify margin: Involved by invasive carcinoma Bile Duct Margin (Cholangiocarcinoma Only) V Cannot be assessed Uninvolved by invasive carcinoma Carcinoma in situ absent Carcinoma in situ present.  Involved by invasive carcinoma Other Margin Ve<sel  marqih Specify margin: - Cannot be assessed Uninvolved by invasive carcinoma Involved by invasive careinoma *Venous (Large Vessel) Invasion (V) Absent *_ Present Indeterminate *Additional Pathologic Findings (check all that apply) None identified  Hepatocellular dysplasia Ductal dysplasia  Cirrhosis/fibrosis) Iron overload chrm' n<rctih3 (3) *V Hepatitis (specify type):  Other (specity):
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diff --git a/output/text/c98e1c21-45e6-479c-bc65-a8b65c1ad0e5.txt b/output/text/c98e1c21-45e6-479c-bc65-a8b65c1ad0e5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..10c440dcec569d307f238a424b35705d48c7e7e0
--- /dev/null
+++ b/output/text/c98e1c21-45e6-479c-bc65-a8b65c1ad0e5.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SLF ICDO-3 Oreinone,wrsthelesl peoyellseuy '8130$ UUID:B2F4C3E3-1740-4C76-86A3-51103954FA72 Redacted L 8t7oJ3 8120(3 Codet hughsJ 812of3 Sute: Msasder HgS Collect date Cb79 (MM/DD/YYYY) Q3[18[4J PATHOLOGY REPORT:S PRIMARY SITE: Bladder 1 - "Surgical excision of bladder + prostate + seminal vesicles": . Urothelial high grade carcinoma, with extensive squamous differentiation. . Neoplasia's size: 4,5 x 4,2 x 3,5 cm. . Presence of foci of necrosis. . Level of infiltration: muscular propria layer. . Angiolymphatic and perineural invasio: not detected. . Ureteral, urethral and soft tissues surgical margins uninvolved by neoplasia. . Gigantocellular foreign body reaction at the stroma. . Absence of neoplastic involvement of the prostate, seminal vesicles and deferens channels bilaterally. . Cystic Chronic cystitis. . Post atrophic prostate hyperplasia. . chronic nonspecific prostatitis. 2 - "excision of left lymph nodes": . Absence os neoplastic involvement on the 5 lymph nodes identified (0/5). 3 - "excision of right lymph nodes": . Absence os neoplastic involvement on the 7 lymph nodes identified (0/7). Topography: bladder, NOS Morphology: transitional cell carcinoma, NOS Staging: pT2b pN0 M0 O1 Syuimcks Tsparnol
+
+--- Page 2 ---
+V4.00 TCGA Pathologic Diagnosis Discrepancy Form Instructions: The TCGA Pathologic Diagnosis Discrepancy Form should be completed when the pathologic diagnosis. documented on the initial pathology report for a case submitted for TcGA is inconsistent with the diagnosis provided on the. Case Quality Control Form completed for the submitted case.. issue Source Site (TSS): TSS Identifier.. _ TSs Unique Patient Identifier:  ompleted By (Interviewer Name on OpenClinica): Completed Date: Diagnosis Information # Data Element Entry Alternatives Working Instructions Provide the diagnosis/histologic subtype(s)documented on Pathologic Diagnosis  High grade urothelial carcinoma with extensive the initial pathology report for this case. If the histology for  Provided on Initial this case is mixed, pravide all listed subtypes.  Pathology Report squamous differentiation. Histologic features of Provide the histologic features selected on the TCGA Case High grade urothelial carcinoma with 0% of  the sample provided. Quatity Control Form completed for this case squamous differentiation for TCGA, as reflected (there is no squamous differentiation)  On the CQCF. Discrepancy between Pathology Report and Case Quality Control Form Provide the reason for.  Provide a reason describing why the diagnosis on the initial the discrepancy  pathology report for this case is not consistent with the  diagnosis selected on the TCGA Case Quality Control Form.  between the pathology Case reviewed by Dr  based on  report and the TCGA top slide image sent from BCR. Case Quality Control Form. Name of Tss Reviewing Provide the name af the pathologist who reviewed this case Pathologist or for TCGA.  Biorepository Director I acknowledge that the above informatlon provided by my institution is true and correct and has been quality controlled.  TSS Reviewing Pathologist or Biorepository Director Date. I acknowledge that the above information provided by my institution is true and correct and has been quailty controlled. The Attending Pathologist or the. Departnent Chairmen has heen informed or is aware of the above discrepancy in diagnoses.. Principal/Investigator'Signature ' Date
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diff --git a/output/text/c9920670-27cb-4f8d-a068-36f70b672291.txt b/output/text/c9920670-27cb-4f8d-a068-36f70b672291.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f180553f262809f00ffda0d7ab3418773f12a75a
--- /dev/null
+++ b/output/text/c9920670-27cb-4f8d-a068-36f70b672291.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID: 56AEE38E-1301-436B-91CE-BCDB523A56E5 A4X-01A-PR Redacted Histopathology Histopathology CitE ICDO-3 Specimen Comments SPECIMEN 1 - Bladder tumour. 2 - Base of tumour. Sit: Y3saddur NoS 067q 3 - Bladder neck. CLINICAL DETAILS YtJ 4/3z|1y New solid bladder tumour. MACROSCOPY 1 - 5g of firm and friable tissue.. 2 - 4 pieces of tissue, the largest 4 mm. 3 - 2 pieces of tissue, the largest 6 mm. MICROSCOPY Part 1 Grade: 3 poorly differentiated with necrosis Growth pattern: Solid with a very focal papillary area.. Type: Transitional cell carcinoma.. Muscularis propria present: Yes. Stromal invasion: Invasion of muscularis propria (pT2) Vascular channel invasion: Not identified. Background urothelium: Carcinoma in situ is present in flat. urothelium. Summary: Transitional cell carcinoma G3 pT2, CIS Part 2 All the tissue was processed and consists of 4 pieces of bladder wall with a. heavy acute on chronic inflammatory cell infiltrate. Some areas there is nuclear smearing due to crush artefact but there is no morphologically evidence. of invasive transitional cell carcinoma in the multiple tissue planes examined. No immunohistochemistry has been done. Part 3 Bladder wall tissue with no evidence of invasive transitional cell carcinoma.. No lining epithelium was included in the biopsy.. SUMMARY Transitional cell carcinoma G3 pT2, CIS. Ref: Pathologists - hw i|9|14 epancy AUR
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diff --git a/output/text/c994c2d4-ad9f-4ddb-a7f3-582e52d58a23.txt b/output/text/c994c2d4-ad9f-4ddb-a7f3-582e52d58a23.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d0f7a3ac69681250081b38209f23c60e8999a97c
--- /dev/null
+++ b/output/text/c994c2d4-ad9f-4ddb-a7f3-582e52d58a23.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+UUID:A845013D-BF15-42FB-8BFE-FCE206E943FE Redacted TCGA-C8-A12N-01A-PR IrB ApPROVED Form 1 Cunical Case Report (For Collection of Cancerous Tissue).. ic4-0-3 IPAA Cauinonn, nifil+nHng duct,NOs 8560|3 St: bresst,nos c5o.9 Informed Consent Aw 5|31| I personally informed this patient that a specimen(s) would be collected to be used for research RESEARCH SUBJECT INFORMATION AND CONSENT purposes. I reviewed the FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Date Signature Name of Physician or Study Coordinator Clinical Information Race  Temperature Height Mari*-1 c+-tus Date of Birth (mm/dd/yyyy) Heart Rate  Blood Pressure Gendar Weight Chief Complaints: 1numr iy te Riqht beayT Symptoms: Daheut fTmol xtr i, Ha teqGF beaytp meyenr.N ;Heersymy Clinical Findings: Wien Performance Scale (Karnofsky Score):   60-70 Symptomatic, in bed less than 50% of day   100 Asymptomatic  80-90 Symptomatic but Fully Ambulatory  20-30 Bed Ridden  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden Date (mm/dd/yyyy) Route Frequency Dose Drug To To NO To To To
+
+--- Page 2 ---
+ PASTMEDICAL HISTORY Status Treatment Diagnosis Date Diagnosis/Disease/Disorder/Injury POBGYN.HISTORYAPY # of Pregnancies Date of First Menses  Menopausal Status   Pre-menopausal # of Live Births Date of Last Menses  Peri-Menopausal Post-menopausal  Hormone Replacement Birth Control: Therapy: W SOCIALHISTORYKAA Environmental Hazards: Occupation: Smoking History. When Quit  Packs/day Duration TYPE (yr) Current Status (yrs)  yes NO Alcohol Consumption Duration When Quit  Drinks/day TYPE (yr) Current Status (yrs)  yES no Drug Use Duration When Quit Frequency TYPE (yr Current Status (yrs)  yes NO Age of Diagnosis  Diagnosis  Relative Yas Cas eex. Date CCSCMEABDATAS  Result Date Test  Result  Negative  Positive: Test CEA Negative  Positive: _ Negative  Positive: HIV CA 15-3  Positive: Negative   Negative  Positive: Hep B  CA 19-9  Positive:   Negative  Positive: Hep C   Negative PSA  Positive: AFP   Negative Other:  Negative  Positive: Other:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+FDIAGNOSTICSTUDIES Date  Results Study Ultrasound X-Ray CT Endoscopy MRI Biopsy Preoperative Clinical Diagnosis Reght neu,!Caue Location of Suspected Distant Metastasis. Location of Suspected Involved Lymph Nodes. Axill Date of Diagnosis Clinical Staging Nj Mo Stage: Treatment Information BTAARSCSURGICAETREATMENEAOAASRNA Date of Procedure Procedure Suraern 'Primary Tumor Size  Detailed Location Organ x x cm bype-wne quadra Keerst Extension of Tumor N0 Lymph Nodes # of Lymph Nodes Location of Lymph Nodes Description S Axilla Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Size Detailed Location  Organ NO Surgical Staging Stage: 7A No. Mo T9 aNEOADJUVENTTHERAPY(Chemo Radiaton Immuno, Hormonal orMolecular Date (mm/dd/yyyy) Route Frequency Dose 1 To Drug/Treatment 1 To 1 To To / 1 To 1 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Date. Time: Collected by: Date: Fime: Preserved by: w.SPECIMENTYPE(#Ofsamples provided)S Slide Blood/Serum/Plasma  Paraffin Block Diseased Normal Frozen Normal Diseased  Norma! Normal Diseased Diseased x X x Time to LN2 Time to Formalin Time to LN2 min  min 40 min  EKTL PATHOLOGICAIEDESCRIPTION Primary Tumor Distance to NAT Size Extension of Tumor Organ NO cm I x Bseces X cm Lymph Nodes # Metastasized # Examined  Location 0 Axilla Distant Metastasis Size Detailed Locatlon Organ NO Pathological Staging TA. Mo Stage: No pT 9  Notes: 4
+
+--- Page 5 ---
+Microscopic Description + Structural Pattern + Cell Distribution +  Streaming Diffuse  Storiform Mosaic Fibrosis Necrosis Palisading Lymphocytic Infiltration Cystic Degeneration Vascular Invasion  Bleeding Clusterized  Myxoid Change  Alveolar Formation Psammoma/Calcification  Indian File Lymphomatous wwwaCellularDifferentiationowwwww Sarcomatous + Adenomatous + Large Cell  Squamous  Round Cell Glandular cell + Small Cell  Squamoid Cell Fibroblast  Cell Stratification  RS Cell/RS Like Spindle Cell Osteoblast  Secretion Inflam. Cell Keratin Lipoblast Intracyt. Vacuole Plasma Cell Desmosome Myoblast  Gland formation  Poor Well X Moderate  Pearl Ceilular Differentiation: II III 0 I Nuclear Atypia: + Aniso Nucleosis + Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell + Mitotic Activity Nuclear Grade: Date Value  Result  Marker  Negative  Positive ER  Negative  Positive PR Negative   Positive  Her-2/neu  Negative  Positive B-Cell Marker  Positive  Negative  T-Cell Marker  Negative  Positive Other: Negative  Positive Other: Final Pathology Report luciaf Criuma Lmaswe Grade: Histological Diagnosis: Comments: Date  Pathologist Principal Investigator U
+
+--- Page 6 ---
+COnsOlIdated Diagnostic patholOgy fOrm* Microscopic Appearance: Histological pattern: J. CELL DISTRIBUTION Diffuse + STRUCTURALPATTERN Streaming Mosaic  Storiform Necrosis Fibrosis Lymphocytic Infiltration Palisading Vascular Invasion Cystic Degeneration Clusterized X Bleeding Alveolar Formation YMyxoid Change Indian File Psammoma/Calcification 2. Cellular features: Squamous [+-Adenomatous + Sarcomatous Lymphomatous + Squamoid Cell Glandular cell  Round Cell Large Cell Spindle Cell Cell Stratification 9 Fibroblast Small Cell Keratin Secretion Osteoblast RS CeI/RS Like  Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell Pear! Gland formation  Myoblast Plasma Cell Otherwise Specified: D, 307 Dr 70% 2.Cellular Differentiation: Well Moderately Poor Nuclear Atypia: Nuclear Appearance Aniso Nucleosis Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity Nuclear Grade Comments: A Date Director, Research Pathology PATHOLOGIST STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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diff --git a/output/text/c9bb3175-110c-4664-ab44-41cf907f89c7.txt b/output/text/c9bb3175-110c-4664-ab44-41cf907f89c7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2401d6b5fd64a04c4e38d50e5e4dec0f3b21cd01
--- /dev/null
+++ b/output/text/c9bb3175-110c-4664-ab44-41cf907f89c7.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+ort Status: LEFT KIDNEY, RADICAL NEPHRECTOMY: RENAL CELL CARcINOMA, (12.8 cm) Fuhrman nuclear grade 3 of 4, chromophobe type. The tumor is confined to the renal parenchyma.. The renal vein, ureter, and inked soft tissue margins are free of tumor. Lymphatic vascular invasion is not seen. addendum. Two lymph nodes are free'of tumor. AJCC (1997) stage T2 N0 MX. NOTE:  Hale's colloidal iron stain is positive supporting the diagnosis.. SURGICAL ADDENDUM: LEFT NEPHRECTOMYS KIDNEY PARENCHYMA AWAY FOR THE TUMOR.SHOWS NO SPECIFIC ABNORMALITIES MICROSCOPIC DESCRIPTION:  Representative sections of the non-tumor parenchyma contains kidney cortex and medulla. There are numerous glomeruli seen (over loo)... Glomeruli with global sclerosis are not seen.  Glomeruli show normal cellularity and reveal. no significant pathological changes. On PAS and Jones' silver methenamine. stain, the glomerular basement membranes appear of normal thickness. Tubules are well preserved... The interstitium shows no fibrosis or active inflammation. Approximately 10% of the sample shows focal tubular atrophy and interstitial fibrosis, as evidenced on the trichrome stains (AFog). Arteries andarte rioles are unremarkable. CLINICAL DATA: History: None given. Operation: Hand assisted laparoscopic left nephrectomy. Clinical Diagnosis: Left renal mass TISSUE SUBMITTED: #1. Left kidney GROSS DESCRIPTION: The specimen is recei patient's name, unit number and "#1. left kidney", and consists of a 545 gram left radical nephrectomy specimen (15.1 x 12.9 x 5.4 cm), to include entire kidney (15.0 x 11.7 x 4.5 cm), portion of dilated ureter (4.3 cm, 0.6 cm in diameter), renal artery (2.5 x 0.5 x 0.5 cm) and renal vein (2.3 x 2.0 cm in diameter). The kidney is partially surfaced by perinephric fat.' No adrenal gland is noted.  Sectioning demonstrates an encapsulated nodular tan/pink lobulated mass (12.8 x 9.5 x 4.4 cm), which is centrally necrotic and hemorrhagic with an apparent 3.0 x 0.8 x 0.8 cm scar. Mass abuts but does not appear grossly to invade the renal pelvis, which is freely mobile, and occupies the majority of the central portion of the kidney, sparing the poles...  The mass expands but does not. appear grossly to invade through the renal capsule, which otherwise demonstrates dense hemorrhagic fibrous adhesions. Closest urethral marg within 3.0 cm (post-fixation), closest renal vein margin is within 2.5 q (post-fixation), and closest renal artery margin is within 3.0 cm. (post-fixation).  There are no additional masses noted upon sectioning.. Transitional epithelium is tan/white and velvety, cortical medullary jur are distinct and the uninvolved portions of the cortical surface appears smooth..  The perinephric adipose tissue is freely mobile. Three represe. sections of the tumor have been submitted for cytogenetics (1A,1B,1c) ana. tumor bank (1A,1B,1C). Representative sections of cortex and medulla are Page: 1 of 2
+
+--- Page 2 ---
+submitted to tumor bank..  Representative non-neoplastic kidney is submitted for electron microscopy, immunofluorescence studies. Representative tumor is retained for electron microscopic studies. Gross photographs are taken. Representative sections corresponding to tissue from 1A,1B and 1C have been  fixation. ave, mult frags,. Micro 2: tumor with respect to renal pelvis, adjacent renal tissue, 1 frag, RSS tumor with respect to adjacent renal parenchyma 2 frags, Micro 3-4: Micro 5-6: tumor and renal capsule (inked blue) 2 frags Micro 7 : uninvolved renal parenchyma,. 1 frag, Micro 8: quick fixed tissue "1A", 1 frag, Micro 9: Micro 10: Micro  11: 2 possible lymph nodes, 2 frags,. Micro 12: scarred area of tumor, 1 frag, SPECIMEN TYPE:  KIDNEY PARTIAL OR TOTAL NEPHRECTOMY Page: 2 of 2
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diff --git a/output/text/c9f9dc8b-68ca-4a7e-be69-4d23df5a51a1.txt b/output/text/c9f9dc8b-68ca-4a7e-be69-4d23df5a51a1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..32fd55110ad5659f17d37af01151770cf31db1bf
--- /dev/null
+++ b/output/text/c9f9dc8b-68ca-4a7e-be69-4d23df5a51a1.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+zCD-o -3 adrenal csr ticalw Q#^c inomc oncscytic cytoltgic fearres 8370/3 C74.0 ND q1113 UUID: BD8435C3-C525-472C-8843-EC2CAE220785 TCgA-Or-A5SL-01a-PR Redacted Specimen(s) Receivod Right adrenal gland Clinical History Right adrenal tumour; production of testosterone and androgens -- right adrenalectomy, ? AcC; ? Adrenet cortical adenoma Macroscopic Description The specimen consists ot a previousty incised adrenal gland welghing 28g and measuring 65 x 30 x 30mm with a A -- Representative sections taken. Microscopic Description Sections of adronal gand show a well circumscrlbed nodule camposed of focaly markedty pleomorphic spithellal ceils (see photograph) with abundant foamy, oncocytc cytoplasm and only occaslonal areas. of clear Cells. Up to 6 mitoses per 50HPF aro present with oocasional atypical mitoses. No capsular,  sinusoidal or vascular invaslon is seen. Exeislon appears complete. COmmeNt :The appearancee are most consistent with an adrenal cortical carcinona. Dr }reports The adrenai iesion is a LOW GRADE ADRENAL CORTICAL. CARCINOMA. The malignant cells display oncocytic cytologlcal features. The tumour dernonstrates 5 of the Weiss criteria of malignancy comprising a mitotic rate of 6 per 50hpt, atypical mitoses, a diffuse growth pattern, cytological atypla and sosinophilc cytoplasm. There is no vascular or sinusoidal invaslon. There is no extra-acrenal spread. There is no coagulative necrosis. There is no perineural growth. Based on these slldes kocal axclsion appears complete. Immunohistochemistry is as follows: K1-67 proliferation index : 8% IGF2: Diffusely positive (perinuclear dot-like pattem) Glucocorticoid receptor: Strongly diffusely (4+) positive This immunonistochenical profile is typical ot adrenal cortical carcinoma and turther supports the diagncsis ot malignancy. Final Summary ADRENAL CORTICAL CARCINOMA; ADRENAL GLAND, RIGHT MARGINS CLEAR Page 1 ot 1 Referred by:
+
+--- Page 2 ---
+I Requesting Doctor's Intormatlon: Report Tc HISTOPATHOLOGY FC MICROSCOPIC:A The adrenal lesion is a LOW GRADE ADRENAL CORTICAL CARCINOMA. The mal|gnant cells display oncocytic cytological features. The tumour demonstrates 5 ot the Weiss criteria of malignancy comprising a mitotic rate of 6 per 50 hpf.. atypical mitoses, a diffuse growth patten, cytological atypia and eosinophilic cytoplasm. There is no vascular or sinusoidal invasion. There is no axtra-adrenal spread. There is no coagulative necrosis. There is no parineural growth. Based on these slides local excision appears complete. Immunohistochemistry is as follaws: KI-67 proliferative index: 8% IGF2: Diffusely positive (perinuclear dot-lilke pattem) Glucocorticoid receptor: Strongly diffusely (4+) positive. This immunohlstochemical profile is typical of adrenal cortical carcinoma and further supports the diagnosis of mallgnancy. SUMMARY: Adrenal gland: Adrenal cortical carcinoma. REPORTING PATHOLOGIST: (Electronic Signature)
\ No newline at end of file
diff --git a/output/text/ca179b8f-5199-4c4c-b7be-e4ef2ef8c2b5.txt b/output/text/ca179b8f-5199-4c4c-b7be-e4ef2ef8c2b5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e9f9db008786d6d74e521bf5fc3d1d37daab0b4d
--- /dev/null
+++ b/output/text/ca179b8f-5199-4c4c-b7be-e4ef2ef8c2b5.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+FINAL DIAGNOSIS: Part 1: breast, Leet, 11 O'clOck segmental mastectomy -- A. -infilTrating DuctaL carcinoma. B.  NeOplasm measures 1.5 Cm On SliDe 1F. C.  NOttingham score 8/9, grade 3 (tubules 3, nucleI 3, mItoses 2). D.  MARGINS OF RESECTION FREE OF NEOPLASM, CLOSEST POSTERIOR AT 0.6 CM. E.  NO LYMPHOVASCULAR INVASION IDENTIFIED. F Er negaTiVe, pr NegatIVe, hEr-2/neu NOt AmpliFIed PEr pReVIOus RepOrTS. G. PATHOLOGIC STAGE pT1C, pN0, pMX. H. DUCTAL CARCINOMA iN SITU, SOLID TYPE, NUCLEAR GRADE 3 WITH COMEDONECROSIS AND CALCIFICATiOn. I. DUCTAL CARCINOMA IN SITU IS IDENTIFIED IN FOUR OF FIFTEEN (4/15) SECTIONS, OUTSIDE OF INVASIVE COMPONENT. J. MARGINS OF RESECTION FREE OF IN SITU CARCINOMA BY GREATER THAN 1.0 CM (see Comment). K.  UNREMARKABLE SKIN. L. FIBROCYSTIC CHANGES. 1cD-0-3 Part 2: Lymph node, Left axillary, Sentinel number 1, biopsy -- Camntma, nifi{trutg dutl nos 85oo]  ONE LYMPH NODE NEGATIVE FOR METASTATIC CARCINOMA (0/1). Sih:busst,Nos C5b.9 3f/u h PART 3: LymPh nODE, LEFt AXILLARy, nOnSentInEL, BIOPSy -- ONE LYMPH NODE NEGATIVE FOR METASTATIC CARCINOMA (0/1). CASE SYNOPSIS: SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST LATERALITY: Left PROceDUrE: Segmental LOCATION: Upper inner quadrant SIZE OF TUMOR:  Maximum dimension invasive component: 1.5 cm. MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: TUMOR TYPE (invasive component): No Ductal adenocarcinoma, NOS NOTTINGHAM SCORE: Nuclear grade: 3 Tubule formation: 3 Mitotic activity score: 2 Total Nottingham score: 8 Nottingham grade (1, 2, 3): 3 ANGIOLYMPHATIC INVASION: No DERMAL LYMPHATIC INVASION: No CALCIFICATIOn: Yes, malignant zones Tumor type, in situ: Solid DCIS present outside of invasive carcinoma component SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No Distance of invasive tumor to closest margin: 6.0 mm. SURG MARGINS INVOLVED BY IN SITU COMPONENT: No LYMPH nODES POSITIVE: 0 LYMPH NODES EXAMINED: 2 METHOD(S) OF LYMPH NODE EXAMINATION: H/E stain SENTINEL NODE METASTASIS: No NON-NEOPLASTIC BREAST TISSUE: FCD t Stage, PatholOgiC: pT1c UUID:6DFA6F0F-098C-4246-87B9-247207874A398 N Stage, pathologIC: TCGA-BH-A0AV-01A-PR pN0 Redacted M Stage, PatholOgiC: pMX ESTROGEN RECEPTORS: previously performed PROGESTERONE RECEPTORS:  previously performed HER2/NEU: zero or 1+
\ No newline at end of file
diff --git a/output/text/ca313a3d-ca84-43a7-9e54-433986c2ffc6.txt b/output/text/ca313a3d-ca84-43a7-9e54-433986c2ffc6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..671a3948ce8cab58bb3722f6acd39c8709fb2f0e
--- /dev/null
+++ b/output/text/ca313a3d-ca84-43a7-9e54-433986c2ffc6.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+TCGA-CW-5584 TISSUE DESCRIPTION: Right kidney (285 grams, 12.0 x 9.0 x 6.0 cm), right periaortic tissue (aggregating 4.0 x 4.0 x1.9 cm), right retroperitoneal lymph node, and anterior vena cava lymph node. DIAGNOSIS: Kidney, right, radical nephrectomy: Grade 3 (of 4) renal cell carcinoma, clear cell type, forms a 6.0 x 4.5 x 4.0 cm mass located. in the mid pole. The tumor extends into the peripheral perinephric fat. A tumor thrombus is present in the renal vein. Coagulative The surgical margins are negative. No renal hilar lymph nodes are identified. The adrenal gland is present and unremarkable.. A separate 4.0 x 4.0 x 4.0 cm benign cyst is present in the inferior pole. Soft tissue, right periaortic, excision: Metastatic grade 3 (of 4) renal cell carcinoma, clear cell type. Lymph node, right retroperitoneal, excision: One (of 1) lymph node shows metastatic grade 3 (of 4) renal cell carcinoma, clear cell type. Lymph node, anterior vena cava,, excision:.  One (of 1) 1ymph node shows metastatic grade 3 (of 4) renal cell carcinoma, clear cell type.
+
+--- Page 2 ---
+Surgical Pathology TISSUE DESCRIPTION; Right kidney (28s grams, 12.0 x 9.0 x 5.0 cm), right neriaortia tissue (aggregating 4.0 x 4.0 x1.9 cm), right retxoperitoneal lymgh node, and~anterior vena cava lyuyh node. DIAGNOSIS: Kidney, right, radical nephrectomy: Grade 3 (of 4) zenal cell carcinoma, clear cell type, forms a 6.0 x 4.5 x 4.0 cn mass located in the mid pole. The tumox extends into the peripher.al perinephrie. fat. A cumox thrombus is present in the renal vein. Coagulative tumor necrosis is absent. * Sarcomatoid differentiation is absent. The surgical margins axe negative.  No renal hilar lynph nodes are identified. The adrenai gland is present and unxemaskable.. sepazate 4.0 x 4.0 x 4.0 om benign cyst is present in the inferior pole. Soft tissue, right periaortic, excision:. Metastatic Jrade 3 (of 4) Lymph node, right retroperitoneal, excision; One (oi: 1) lymph nods shows metastatic grade 3 (of 4) renal cell carcinoma, clear cel1 type. Lymph node, antexior vena cava,, excision: One (of 1; lymph node shows metastatic grade 3 (of 4)'senal cell cazcinoma, clear cell type.
\ No newline at end of file
diff --git a/output/text/ca436e58-3866-47ca-b59b-267f587daf39.txt b/output/text/ca436e58-3866-47ca-b59b-267f587daf39.txt
new file mode 100644
index 0000000000000000000000000000000000000000..eb5e2886e3e824b48c5171276c346c6f485f2007
--- /dev/null
+++ b/output/text/ca436e58-3866-47ca-b59b-267f587daf39.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+Jcs-0-3 C50.8 2/fn CqcF! brnst, Nos C50.9 IRB APPROVED Form Revised Clinical Case Report (For Collection of Cancerous Tissue) UUID:40807889-2CDB-463A-8773-771017E73DBC TCGA-C8-A1HF-01A-PR Redacted Informed Consent I personally informed this patient that a specimen(s) would be collected to he nsed for recearch. purposes. I reviewed the with the patient and answered any questions the patient had. Ihe panenr inen signed the. consent form as a free and voluntary act. A copy of this informed consent document will be retained at. our institution. Signature Date Name of Physician or Study Coordinator Clinical Information ACSGENERALINEORMATIONSTHSA  Marital Status Race Temperature Date of Birth (mm/dd/yyyy) Height Married 3Jc d.55 m  Single  Widow  Blood Pressure Heart Rate Weight  Divorced Gender 887m Female 4419  Maie TMNAHISTORYOEPRESENTIELNESSCLMSAPAO the ert brer.? Chief Complaints: I ww bqF beacT me mmh aq Symptoms: Pahent Hud n hmw F b3e,t hu 3x2h, tnwr Clinica! Findings: -- In Hae lover hay Performance Scale (Karnofsky Score):   60-70 Symptomatic, in bed less than 50% of day  100 Asymptomatic  80-90 Symptomatic but Fully Ambulatory  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden -  20-30 Bed Ridden WOIRNNKSSPASTMEDICALHISTORYASP Treatment Status Dlagnosis Date Diagnosis/Disease/Disorder/Injury
+
+--- Page 2 ---
+MAOBGYNHISTORYOEO Menopausal Status Date of First Menses # of Pregnancies t Pre-menopausal fensnla?  Peri-Menopausal Date of Last Menses # of Live Births  Post-menopausal Blrth Controi: Condom  Oral Contraceptive YIuD  Hormone Replacement  Other: Therapy: PSOCIAIHISTORYN Environmental Hazards: Occupation: Smoking History TYPE  Packs/day Duration When Quit Current Status (yrs) (yr) O YES &NO Alcohol Consumption Duration When Quit Current Status TYPE  Drinks/day (yrs) (y)  yes nO Drug Use Frequency Duration When Quit Current Status TYPE (yrs) (y)  yes bNO CMZIMSNFAMIEYMEDICAEHISTORYHNRSTAOH Age of Diagnosis Diagnosis Relative Motler lss derlly Cuce as ASEABDATASH Test  Result Date Result Date Test CEA  Negative  Positive: HIV Negative  Positive: CA 15-3  Negative  Positive: Hep B Negative  Positive: CA 19-9   Negative  Positive: Hep C   Negative  Positive: PSA  Negative  Positive: AFP  Negative  Positive: E Other: Other:  Negative  Positive:  Negative  Positive: B/T Cell Markers: ECCCEZAEEDIAGNOSTICSTUDIESCEEPTSSTE Date Results Study Ultrasound X-Ray CT Endoscopy MRI  Biopsy 2
+
+--- Page 3 ---
+1 Preoperative Clinical Diagnosis est breat Cacan Location of Suspected Involved Lymph Nodes.  Location of Suspected Distant Metastasis Axiln NU Clinical Staging Date of Diagnosis T9 NA MO Stage: I 2 Treatment Information PNSPNARARLAESURGICALTREATMENTKHESRAKOSSA Procedure Date of Procedure Datey's Swrsery Primary Tumor Detailed Location Size Organ Q.x 7 x cm Extension of Tumor 90 Lymph Nodes Location of Lymph Nodes # of Lymph Nodes Description Axille 12  Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Detailed Location  Size Organ NO Surgical Staging TL Nc m o Stage: A SsrNEOADJUVENTTHERAPY(Chemo, RadiationmmunoHormonalorMorecular aa Frequency Date (mm/dd/yyyy). Drug/Treatment Dose Route To / To NO 1 To Date (mm/dd/yyy) Dose Route Freguency Drug/Treatment To 1 To / 1 1 / / To 1 WEESNTSOTHERMEDICATIONSASSMRRSSA Date (mm/dd/yyy) Dose Route Frequency Drug To 1 To / 1 To 1 1 To 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by: . Date: - .'ime: Date. .Time: Preserved by:. (Blood/Serum/Plasma Slide Frozen Paraffin Block Discased  Normal Diseased Normal Diseased Normal Diseased  Normal x + Time to Formalin Time to LN2  Time to LN2 min 62 min  min CARPATHOLOGICALDESCRIPTIONUETSRSERRMS Primary Tumor Extension of Tumor Distance to NAT Organ Size. 2.1x 2 Rseay? cm cm Lymph Nodes # Examined # Metastasized Location 12. 0 Axilla Distant Metastasis Detailed Location Size Organ ND Pathological Staging N o M 0 Stage: L A pT_9 Notes: 4
+
+--- Page 5 ---
+CONSOLIDATED DIAGNOSTIC PATHOLOgy FORM* Microscopic Appearance: 1. Histological pattern: CELL DISTRIBUTION Diffuse + STRUCTURAL PATTERN WStreaming  Mosaic Storiform Necrosis XFibrosis Lymphocytic Infiltration Palisadin? Vascular Invasion Cystic Degeneration Clusterized Bleeding Alveola Formation Myxoid Change Indian File X  Psammoma/Calcification 2. Cellular features: Sguamous +Adenomatous + Sarcomatous + Lympbomatous  Squamoid Cell Glandular cell Round Cell Lare Ceu Spindle Ccll Cell Stratification Fibroblast Small Cell Keratin Secretion Osteoblast  RS CelV/RS Like Desmosorne Intracyt. Vacuole  Lipoblast Inflam. Cell Pear! Gland formation Myoblast Plasma Cell Otherwise Specified: D 757 Dv Zs% D2 71% Dg s0Z 2.Celludar Differentiarion: Well Moderatejy Nuclear Atypia: Neckar Apeearaace Aniso Nucleosis Hyperchrornatism  Nucleolar Prominent  Multinuckeated Giant Celld Mitotic Activity Nuckcar Grade Histological Diagnosis:_Ihilteatsy Aneta/ Carzms, ?s. 6- 3 Comments: Date PATHOLOGIST STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CONTRISUTOR AND.
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diff --git a/output/text/ca671db2-285c-4eb1-9eb4-618299afcc12.txt b/output/text/ca671db2-285c-4eb1-9eb4-618299afcc12.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7a96b11667f89d879d452da6276462d3fa212bd8
--- /dev/null
+++ b/output/text/ca671db2-285c-4eb1-9eb4-618299afcc12.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+*******MODIFIED REPORT - REVIEW ADDENDUM SECTION ******* DIAGNOSIS (A) LEFT BUCCAL MARGIN: Squamous mucosa with moderate dysplasia. Margins are free of tumor. (B) RIGHT PALATE AND MARGIN: Squamous mucosa, no tumor present. (C) DEEP BUCCAL MARGIN: Fibroadipose tissue. No tumor present. (D) MUCOSA OF MAXILLARY SINUS: Respiratory mucosa, no tumor present. (E) SUPERIOR MARGIN (TRUE MARGIN INKED): Fibromyxoid mucosa. No tumor present. (F) LEFT INFERIOR TURBINATE: Fibrovascular tissue. No tumor present. (G) POSTERIOR MARGIN: Squamous mucosa. No tumor present. (H) SOFT PALATE, TRUE MARGIN: Squamous mucosa with acute and chronic inflammation, no tumor present.. (I) DEEP MARGIN, LEFT RETROMOLAR TRIGONE: Fibroconnective tissue. No tumor present. (J) LEFT MANDIBULAR MARGIN: Fibroconnective tissue. No tumor present. (K) RIGHT INFERIOR TURBINATE: Fibrovascular tissue. No tumor present. (L) MAXILLARY SINUS MUCOSA: Respiratory mucosa. No tumor present. (M) LEFT MAXILLA TOTAL PALATECTOMY IN A BLOCK INCISION THAT INCLUDES PART OF THE LEFT MAXILLA, HARD PALATE AND SOFT PALATE: INVASIVE SQUAMOUS CELL CARCINOMA, MODERATELYDIFFERENTIATED WITH A DEPTH OF INVASION OF 0.5 CM. Entire report and diagnosis completed by GROSS DESCRIPTION (A) LEFT BUCCAL MARGIN, TWO MARGINS INKED, STITCH IS EQUAL TO SUPERIOR- The specimen is covered on one aspect by skin and on the other by mucosa. The superior end is marked by a stitch. The true margin is inked yellow. The true  margin is submitted in sections one to four starting from superior to inferior. The remaining specimen is submitted in section five. Page 1 of 4 Surgical Pathology Report File under: Pathology
+
+--- Page 2 ---
+*FS/DX: NO TUMOR PRESENT. B) RIGHT PALATE AND MARGIN-Three portions of unremarkable tan-pink mucosa 0.4 x 0.1 x 0.1 cm1.1 x 0.1 x 0.1 cm,and 0.9 x 0.5 x 0.2 cm). The true margin of each portion of tissue has been inked previously by the surgeon. INK CODE: Yellow-true margin. SECTION CODE:B1.two smaller portions of mu a submitted for frozen section; B2, B3, perpendicular margin largest portion of mucosa submitted entirely for frozen section. *FS/DX: NO TUMOR PRESENT. (C) DEEP BUCCAL MARGIN - A portion of adipose tissue (3.5 x 1.5 x 0.5 cm). The true margin is inked purple by the surgeon. The cut surface shows unremarkable adipose tissue. INK CODE:Blue-true deep margin. SECTION CODE: C1-C7, entirely submitted specimen (perpendicular margins) for frozen section. *FS/DX:NO TUMORPRESENT (D) MUCOSA OF MAXILLARY SINUS-A white-pink irregular fragment of tissue (1.0 x 0.7 x 0.2 cm). The specimen is dissected and entirely submitted in D. (E) SUPERIOR MARGIN, TRUE MARGIN INKED- Received an elongated, thin ellipse of skin (2.1 x 0.1 cm) excised to a depth of 0.2 cm. The true margin is inked with blue ink. The specimen is serially sectioned and entirely submitted for frozen section. INK CODE:True margin-yellow. SECTION CODE: E1, entire specimen. *FS/DXNO TUMOR PRESENT. F) LEFT INFERIOR TURBINATE- Multiple light pink irregular soft tissue,in aggregate 1.9 x 2.1 x 0.5 cm. Entirely submitted. SECTION CODE:F,specimen in toto (G)POSTERlOR MARGIN-A portion of tan-pink soft tissue (2.2 x 0.5 x 0.5 cm). The true margin is inked on surface previously by the surgeon. INK CODE:Blue-true margin. SECTION CODE: G1-G3, perpendicular sections of true margin submitted entirely for frozen section. *FS/DX: NO TUMOR PRESENT. H SOFT PALATE,TRUE MARGIN-A tan-pink portion of soft tissue 3.0 x2.1 x 0.8 cm). The surface has been previously inked by the surgeon designating the true margin. A trapezoid piece of mucosal soft tissue (3.0 x 2.5 x 0.4 cm).The true resection margin is marked with blue ink.Cut surfaces are unremarkable. INK CODE:Blue-true margin. H1, H2, bisected tissue with the margin submitted en face.H3-H5, specimen with perpendicular margin. *FS/DX:NO TUMORPRESENT 1DEEP MARGIN,LEFT RETROMOLAR TRIGONE-Two portions of tan-pink tissue 1.5 x 1.0 x 0.9 cm and 1.0 x 0.5 x 0.3 cm The true margin has been inked previously by the surgeon. INK CODE: Blue-true margin. SECTiON CODE:11.smaller portion of tissue,perpendicular margin;12-14,larger portion of tissue,perpendicular margin (submitted entirely). *FS/DX: NO TUMOR PRESENT. J LEFT MANDIBULAR MARGIN-A tan-pink portion of soft tissue 0.9 x 0.5 x 0.2 cm).One surface of the specimen has been previously inked by the surgeon and desi ted the true margin. Submitted entirely for frozen section. INK CODE: Blue, true margin *FS/DX:NO TUMORPRESENT (K RIGHT INFERIOR TURBINATE-A 3.0 x 1.3 x0.6 cm polyp mucosal soft tissue with a diffusely congested out surface Representative sections are submitted in Page 2 of 4 Surgical Pathology Report File under:Pathology
+
+--- Page 3 ---
+(L) MAXILLARY SINUS MUcsOA- A 4.0 x 2.0 x 0.1 cm transparent mucosa with attached fragments of bone. No abnormalities are identified. The entire soft tissue submitted in L1 and the bony part is for submitted in L2 for decalcification.. (M) LEFT MAXILLA TOTAL PALATECTOMY IN A BLOCK INCISION THAT INCLUDES PART OF THE LEFT MAXILLA, HARD PALATE AND SOFT PALATE, which is 5.5 cm anterior to posterior, 4.3 cm lateral to lateral, and 2.8 cm superior to inferior. The attached soft tissue extends 4.0 cm beyond these one margins. The soft palate mucosa has a 2.0 cm ulcer with irregular edges and necrotic base. This corresponds to a tumor which invades the underlying soft tissue to a maximum depth of 1.0 cm. The adjacent mucosa overlying the hard palate is finely granular and has a verrucous architecture. It seems to be confined to the mucosa and submucosa. The soft tissue is sequentially submitted for grossing from the medial to the lateral aspect of the specimen.The bony parts are sent to the bone lab for decalcification. INK CODE: Black-posterior and medial, one resection margin SECTION CODE: M1-M2, the entire soft tissue including the tumor and adjacent lesion, progressing from he medial to the later; M22, he posterior bony resection margin CLINICAL HISTORY Squamous cell carcinoma, retromolar trigone and palate SNOMEDCODES Page 3 of 4 Surgical Pathology Report File under: Pathology
+
+--- Page 4 ---
+ADDENDUM DIAGNOSIS (L) MAXILLARY SINUS MUCOSA: MINUTE FRAGMENT OF SQUAMOUS CARCINOMA. MARGINS FREE (M) LEFT MAXILLA, TOTAL PALATECTOMY: SQUAMOUS CARCINOMA INVADING PERIOSTEUM AND SUPERIFICIAL BONE. Bony margins of resection free of tumor. Entire report and diagnosis completed by Released by: Page 4 of 4 Surgical Pathology Report File under: Pathology
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diff --git a/output/text/caadc160-f8ac-4bca-9ab1-bb9b5960bec4.txt b/output/text/caadc160-f8ac-4bca-9ab1-bb9b5960bec4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7ea7cac138a30bb57a9827275afa79bed13667c2
--- /dev/null
+++ b/output/text/caadc160-f8ac-4bca-9ab1-bb9b5960bec4.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:94F7B032-1181-44E0-AB16-4A672A88E086 TCGA-AY-A69D-01A-PR Redacted SURGICAL PATHOLOGY Case Number : Diagnosis: A: Colon, transverse, partial colectomy. Tumor Histologic Type: invasive adenocarcinoma. Histologic Grade: moderately differentiated (grade 2 of 4) Tumor Location: transverse colon. Depth of Invasion:. -Through muscularis propria and into the subserosa and pericolic soft tissue ICD-o3 Lymphovascular Invasion: not identified dnscarersmo fUSS 8140/3 Perineural Invasion: not identified Site Ironewuae colen Cl8.4 Margins: Oj sle/1 3 Proximal margin: negative Distal margin: negative Mesenteric margin: negative Distance of carcinoma from closest margin (specify): 6.6 cm to the closest distal margin of resection Regional Lymph Nodes:. Total number with metastasis: 0 Total number examined: 25 Additional Pathologic Findings: Immunohistochemical stains for MLH-1, Msh-2, PsH-6 and pMs-2 are performed on block A7. The tumor cells demonstrate appropriate positive nuclear expression for all four markers. This is the normal phenotype and does NoT support a diagnosis of. microsatellite instability/hereditary non-polyposis colorectal cancer (Hnpcc). Separate molecular testing for microsatellite instability markers will be performed and reported separately.. Appropriate controls are performed.. AJCc Pathologic TNM Stage: pT3 pNO Note: This pathologic stage assessment is based on information available at the time of this report, and is subject to change. pending clinical review and additional information..
+
+--- Page 2 ---
+Clinical History: -year-old female with colon cancer. Gross Description: Received is one appropriately labeled container, additionally labeled "transverse colon and omentum." It consists of a 23.5 cm long x 5.2 cm in circumference segment of large bowel with attached omentum (30.4 x 15.6 x 0.8 cm), pericolonic adipose tissue up to 4.3 cm thick and appendix is absent. There is a 5.2 x 2.6 x 0.7 cm (protruding into lumen) firm, pink/tan, centrally ulcerated circumferential mass with raised borders that is 10.7 cm from the proximal margin and 6.6 cm from the distal margin. The distal margin has an attached suture, which is inked blue and the serosa overlying the mass is inked black. The mass on cut section is firm, smooth, gray/white, extends 1.1 cm through the wall and into the mesentery focally retracting the serosa but not extending through it, and 3.5 cm from the mesenteric margin. The uninvolved mucosa is tan with normal folding pattern. The omentum has patchy areas of hemorrhage but nodules are absent. The pericolonic adipose tissue is dissected for lymph node candidates of which 29 are identified ranging from 0.2 cm in greatest dimension up to 0.8 x 0.8 x 0.8 cm in greatest dimension. Block summary: Al - mesenteric margin, en face A2-A3 - proximal mucosal margin, en face A4-A5 - distal mucosal margin, en face A6 - mass retracting the serosa A7-A8 - each contains deepest extension of mass with positive lymph node in A8 A9 - mass with distal mucosa Al0 - mass with proximal mucosa Al1 - omentum A12-Al4 - each contains six lymph node candidates A15-A16 - each contains four lymph node candidates A17 - two lymph node candidates, each bisected, one is inked black A18-A19 - one lymph node candidate, serially sectioned Tumor and normal are given to
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diff --git a/output/text/cac8b604-d6bb-439a-815d-c7cceb1690a9.txt b/output/text/cac8b604-d6bb-439a-815d-c7cceb1690a9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c48c5a89ccd3fe17b81e0df1a7c563b9ba718bcf
--- /dev/null
+++ b/output/text/cac8b604-d6bb-439a-815d-c7cceb1690a9.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Results SURGICAL PATHOLOGY Patient info. Patient Name  Sex DOB  Male Results Physician: SPECIMEN #: ********* ********************** FINAL DIAGNOSIS: LEFT KIDNEY AND LEFT ADRENAL GLAND, RADICAL NEPHRECTOMY - RENAL CELL CARCINOMA, PAPILLARY TYPE, NUCLEAR GRADE II/IV. - ADRENAL GLAND WITH NO PATHOLOGIC DIAGNOSIS. Comment: The tumor is present as a 5.0 cm mass arising within the lower portion of the left kidney. The tumor extends beyond the normal renal parenchyma into the perirenal adipose tissue. No extension into renal sinus is seen. The ureteral and renal vascular. margins of excision are negative for neoplasm.  No involvement of the left adrenal gland is seen. UUID:DD45EC6D-A44D-4B7D-9EBA-1ACDEC258FF5 TCGA-IA-A83V-01A-PR Redacted  Report Electronically Signed Out SPECIMEN(S) SUBMITTED: LEFT KIDNEY LEFT ADRENAL GLAND C64.9 CLINICAL DATA: tJ10//13 RENAL MASS GROSS DESCRIPTION: A.  Received is a specimen labeled "left kidney and left adrenal gland". The specimen consists of a left kidney containing a mass and is surrounded by an irregular envelope of fibroadipose tissue. The neoplasm does not appear to extend into the perirenal fat. The specimen weighs 344.50 grams after removing perirenal fat. The. specimen is sectioned from superior to inferior. A mass involves the lower portion of the kidney. On section the tumorous mass is roughly spherical and measures 5 x 5 x 4 cm. It is composed of yellow tissue with foci of hemorrhage and softening. The tumor does. not invade the pelvocalyceal system or the renal sinus. The tumor is sharply demarcated from the renal parenchyma which appears essentially unremarkable. Satellite nodules of tumor are not present in the renal tissue. Dissection of the renal veins particularly those draining the area of the mass does not show intravascular presence of the neoplasm. The adrenal gland is present and measures 5 x 4 x 0.4 cm and weighs 11.31 grams. It is not involved by the mass. A 5 cm segment of ureter is present and is essentially unremarkable. Representative sections are submitted in formalin with the following designations: #l ureter and vessels; #2 pelvis; #3 sinus; #4 - #6 tumor in respect to the capsule; #7 tumor; #8 perirenal fat; #9 adrenal gland. Page 1 of 2
+
+--- Page 2 ---
+Patient ID #: Financial #: Date of Report: DOB: Date of Procedure: Date of Receipt:. Physician: Location: Lab and Collection. SURGICAL PATHOLOGY I on. Lab and Collection Information. Result History SURGICAL PATHOLOGY ) on Order Result History Report.. Result Information Result Date and Time. Status Provider Status Final result Ordered Status: This result is currently not released to Display Full Result Report Display Order Report 031 Page 2 of 2
+
+--- Page 3 ---
+Page 1 of 1 TCGA Pathologic Diagnosis Discrepancy Form 4.05 ) Study Subject Person ID: N/A ID: Study/Site: TCGA Kidney renal papillary cell carcinoma - (Kidney renal papillary cell  Age: N/A carcinoma) Event:  PathDiscrepancy Date of  Birth: Interviewer: Sex Tumor Identifier Provided on Initial Case Provide the tumor identifier documented on the initial case quality Quality Control Form control form for this case.  Pathologic Diagnosis Provided  renal cell Provide the diagnosis/ histologic subtype(s) documented on the initial pathology on Initial Pathology Report carcinoma report for this case. If the histology for this case is mixed, provide all listed subtypes. Histologic features of the sample provided for papillary Provide the histologic features selected on the TCGA Case Quality TCGA, as reflected on the CQCF type Control Form completed for this case. Discrepancy between Pathology Report and Case Quality Control Form Provide the reason for the discrepancy confirmation of clarification of Provide a reason describing why the diagnosis on the between the pathology report and the KIRP Type II provided in initial pathology report for this case is not consistent with TCGA Case Quality Control Form discrepancy note the diagnosis selected on the TCGA Case Quality Control Form. Name of Tss Reviewing Pathologist or Provide the name of the pathologist who reviewed this  Biorepository Director case for TCGA.
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diff --git a/output/text/cad6d436-bcba-45f9-a0c8-2b0dd9ffdb5c.txt b/output/text/cad6d436-bcba-45f9-a0c8-2b0dd9ffdb5c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..22a8b2e0a0130612d97012fcb4ecc2077ec1c1fc
--- /dev/null
+++ b/output/text/cad6d436-bcba-45f9-a0c8-2b0dd9ffdb5c.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+CD-O-3 trocytoma,grodle III 9401/3 Clatscylere, anaplastie. 9451/3 Surgical Pathology Report Sute : Bain, eupaterleuil NsS 071.0 Patient Name: Phone #: Accession #: Med. Rec. #: Client: Taken: QpJ 7/q4113 DOB: (Age: ) Location: Received: Gender: F Accnt:  Reported: Physician(s): Phy Location: UUID:7FA0F0F7-F7B8-4127-988E-C3A43496CCCA Clinical History TCGA-DU-A6S7-01A-PR Redacted Brain tumor. Operative Diagnoses Operation / Specimen A: Brain, left frontal, craniotomy Pathologic Diagnosis A. Brain, left frontal, craniotomy: 1. Anaplastic astrocytoma, WHO grade 3 2. Negative for co-deletion of chromosomal arms 1p and 19q 3. Positive for IDH1-R132S mutation 4. Ki-67/ MIB1 proliferation index: up to approximately 10% See comment. Comment The diffuse astrocytoma has an area with up to 4 mitoses in 10 high power fields. There is no definite microvascular proliferation and no tumor necrosis identified in the initial and deeper sections. The immunostain for the  mutant IDH1-R132H protein is negative. A point mutation is detected in IDH1 by DNA sequencing (see) attached report). Overall, this diffuse glioma is consistent with anaplastic astrocytoma, WHO grade 3. ***Electronically Signed Out*** Senior Staff Pathologist Consultant: Senior Staff Pathologist Procedures/Addenda Loss of Heterozygosity 1p, 19q Assay (LOH) Date Ordered: Date Reported: Interpretation NEGATIVE: Allelic loss on chromosome arm 1p and chromosome arm 19q is NOT detected. Surgical Pathology Page 2 of 4 Informative loci are: D1S548, D1S1592, D1S552, D19S219, D19S606, and D19S1182 Results-Comments Testing performed on DNA extracted from tumor paraffin block (A2). DNA extracted from a corresponding blood specimen was used as a normal reference control. H and E slide was examined and tumor DNA was enriched by microdissection TEST DESCRIPTION: Allelic loss is assessed by PCR assay in Normal DNA (baseline)/ Tumor DNA pairs using 3 markers at both 1p and 19q. The 3 markers on 1p are D1S548, D1S1592, and D1S552 (with D1S468, D1S1612, and D1S496 as backup markers) and the 3 markers on 19q are D19S219, D19S412, and PLA2G4C (with D19S606 and
+
+--- Page 2 ---
+D19S1182 as backup). All markers are microsatellites (2 or 4 nt repeats) except PLA2G4C which is a minisatellite (26 nt repeat) polymorphism. The markers were selected based on heterozygosity score, amplicon size, and ease of interpretation. The backup markers are used if the first line markers at that chromosome arm are. uninformative or otherwise ambiguous in their interpretation. LOH at all informative loci on each chromosomal arm represents the typical finding in oligodendrogliomas with 1p and 19q deletion.. FDA COMMENT: The above data are not to be construed as the results from a stand-alone diagnostic test. This test was developed and its performance characteristics determined by the as required by CLiA ' 88 regulations. It has not been cleared or approved for specific uses by the U.S. Food and Drug Administration (FDA). The FDA has determined that such clearance or approval is not necessary. These results are provided for informational purposes only, and should be interpreted only in the context of established procedures and/or diagnostic criteria. TECHNICAL SENSITIVITY: The presence of >15% non-neoplastic cells in the sample may preclude the detection of allelic loss. ***Electronically Signed Out*** Senior Staff Pathologist IDH1 Mutation Detection Assay Date Ordered: Date Reported: Interpretation POsirivE - There is evidence of IDH1 point mutation as indicated by the nucleotide change in codon 132 compared to the electropherogram of the reference normal sample (wild type).. The amino acid substitution is p.Arg132Ser Results-Comments TEST DESCRIPTION: IDH1/2 Mutation Analysis Test performed on DNA extracted from tumor paraffin block. -A1 H and E slide was examined and no microdissection was needed. Mutation of IDH1 occurs early in glioma progression with somatic mutations of the R132 residue of IDH1 identified in majority (>70%) of grades Il and Ill astrocytomas and oligodendrogliomas, as well as in secondary GBMs that developed from these lower grade lesions. Mutation analysis of closely related IDH2 revealed mutations of IDH2 residue R172, with most mutations occurring in tumors lacking IDH1 mutations. Tumors with IDH1 or IDH2 mutations have distinctive genetic and clinical characteristics, and patients with such tumors have a better outcome than those with wild type IDH genes.  Surgical Pathology Page 3 of 4 Mutations in IDH1/2 are detected by DNA sequencing procedures. The limit of detection of standard bidirectional sequencing is approximately 20-25%. In order to increase assay sensitivity tumor enrichment must be performed by manual microdissection when tumor cells in the block constitute less than 50% of nucleated cells FDA COMMENT: The above data are not to be construed as the results from a stand alone diagnostic test. This test
+
+--- Page 3 ---
+ was developed and its performance characteristics determined by the as required by CLIA "88 regulations. It has not been cleared or approved for specific uses by the US Food  and Drug Administration (FDA). The FDA has determined that such clearance or approval is not necessary. These results are provided for informational purposes only, and should be interpreted only in the context of established procedures and/or diagnostic criteria. ***Electronically Signed Out***  Senior Staff Pathologist. IDH2 Mutation Detection Assay Date Ordered: Date Reported' Interpretation NEGATivE - There is no evidence of IDH2 point mutation, as indicated by the absence of any nucleotide changes in codon 172 of the IDH2 gene compared to the electropherogram of the reference normal sample (wild type). Results-Comments TEST DESCRIPTION: IDH2 Mutation Analysis Test performed on DNA extracted from tumor paraffin block. -A1 H and E slide was examined and no microdissection was needed. Mutation of IDH1 occurs early in glioma progression with somatic mutations of the R132 residue of IDH1 identified in majority (>70%) of grades Il and IIl astrocytomas and oligodendrogliomas, as well as in secondary GBMs that developed from these lower grade lesions. Mutation analysis of closely related IDH2 revealed mutations of IDH2 residue R172, with most mutations occurring in tumors lacking IDH1 mutations. Tumors with IDH1 or IDH2 mutations have distinctive genetic and clinical characteristics, and patients with such tumors have a better outcome than those with wild type IDH genes.. Mutations in IDH1/2 are detected by DNA sequencing procedures. The limit of detection of standard bidirectional sequencing is approximately 20-25%. In order to increase assay sensitivity tumor enrichment must be performed by manual microdissection when tumor cells in the block constitute less than 50% of nucleated cells. FDA COMMENT: The above data are not to be construed as the results from a stand alone diagnostic test. This test was developed and its performance characteristics determined by the  as required by CLiA "88 regulations. It has not been cleared or approved for specific uses by the US Food and Drug Administration (FDA). The FDA has determined that such clearance or approval is not necessary. These results are provided for informational purposes only, and should be interpreted only in the context of established procedures and/or diagnostic criteria. ***Electronically Signed Out**** Senior Staff Pathologist Intra-Operative Consultation A. Brain tumor, excision biopsy: Gliofibrillary neoplasm, consistent with diffuse glioma. Cytological smears are performed at the and the results are reported to the Physician of Record.
+
+--- Page 4 ---
+Surgical Pathology Page 4 of 4 Senior Staff Pathologist Gross Description A. Brain, left frontal, craniotomy: FIXATIVE: None GENERAL: A 1.4 x 1.2 x-0.5 cm aggregate of grey-tan to dusky soft tissue, submitted for intraoperative evaluation. SECTIONS: Entirely submitted in A1 - A2. ICD-9(s): 191.1 191.1 Billing Fee Code(s): Histo Data Part A: Brain, left frontal, craniotomy Taken: Received: Stain/cnt Block Ordered Comment H&E x1 1 IDH1-sId x 1 1 IDH1-sId x 1 1  no trim please 1DH2-sId x 1 1 MIB1-DA x 1 1 Rct 1 H&E x1 1 no trim please Rct 2 H&E x1 1 TPS H&E x1 1 H&E x 1 2 LOH-sld x 1 2 Rct 1 H&E x1 2 Rct 2 H&E x 1 2
\ No newline at end of file
diff --git a/output/text/cafa497d-3987-42dc-ac87-de4d7dbd2d97.txt b/output/text/cafa497d-3987-42dc-ac87-de4d7dbd2d97.txt
new file mode 100644
index 0000000000000000000000000000000000000000..451ecdb3dcd5efe5c3a7eeb1209cd7905e884f35
--- /dev/null
+++ b/output/text/cafa497d-3987-42dc-ac87-de4d7dbd2d97.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis This concerns a resected sigma sample with a moderately differentiated adenocarcinoma with histopathological differentiation grade G2, with ulceration of the inner surface of the tumor, with necrosis, with peritumoral, chronic recurrent secondary inflammation with an acute inflammation flare, with carcinomatous lymphangitis, with tumor infiltration of the sigma wall layers to the subserous fatty connective tissue, with moderate chronic. 1ymphadenitis of the tumor-free lymph nodes (0/13), with tumor-free overview slices from the resection margins and from the anastomosis ring, as well as with a sigma diverticulosis. According to the preparation sections at hand, the spreading of the tumor of the sigma. carcinoma corresponds to a tumor stage of pT3, pN0, MX, L1, R0.
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diff --git a/output/text/cb0bea32-2df5-4479-9fb3-e5421c48c57c.txt b/output/text/cb0bea32-2df5-4479-9fb3-e5421c48c57c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e6959092728508ae2373894f15ca6baa7983143f
--- /dev/null
+++ b/output/text/cb0bea32-2df5-4479-9fb3-e5421c48c57c.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+837D] 3 Oc ID: Site: Cortex of adrenolghud. 074.0 TSS ID: AO4/29/13 Tumor ID: UUID:9C523464-BFDB-4C7A-972E-2EBECDBBFF3E SPECIMEN(S): Redacted TCGA-PA-A5YG-01A-PR A: Lipoma B: Left adrenal gland and mass. FINAL DIAGNOSIS: B. Adrenal gland, left, excision:. - Adrenal cortical carcinoma, low grade - 7.8 cm greatest dimension. - 171 gm - Margins of resection free of malignancy - See case summary. A. Soft tissue, back, excision:. - Lipoma. COMMENT: This case has been reviewed, who concurs with the interpretation of low-grade adrenal cortical carcinoma. The findings of a sheet-like infiltration pattern, necrosis, capsular vascular invasion, and nuclear atypia are fairly typical of carcinomas. In addition, the size in excess of 7 cm and the weight of 171 gm are also both more lw 7/13 ALIFIED
+
+--- Page 2 ---
+typical of carcinoma. The eosinophilic cytoplasm is also more typical of carcinoma. Absolute distinction between adrenal cortical adenomas and carcinomas is not always possible; however, multiple series have shown having many of the features described are associated with malignant behavior. American Journal Clinical Pathology, 1996; 105:76-86. Specimen: Adrenal gland; received: Fresh Procedure: Adrenalectomy, total. Specimen Integrity: Intact. Specimen Size: Greatest dimensions: 17 x 8 x 4.9 cm Specimen Laterality: Left Tumor Size: a 7.8 x 5.7 x 4.6 cm Tumor Gland Weight: 171 gm. Histologic Type: Adrenal cortical carcinoma Margins: Margins uninvolved by tumor Lymph-Vascular Invasion: Small vessel (capillary lymphatic) Pathologic Staging: pT2 pNX Primary Tumor (pT): pT2: Tumor greater than 5 cm, no extra-adrenal invasion Regional Lymph Nodes (pN): pNX: Cannot be assessed No nodes submitted or found Distant Metastasis (pM): Not applicable
+
+--- Page 3 ---
+I have personally reviewed all specimens and or slides, including the. listed special stains, and used them with my medical judgement to  determine the final diagnosis. CLINICAL HISTORY: The patient is a -year-old male with growth on adrenal gland. Operative Procedure: Lipoma excision and left adrenal gland and mass excision. GROSS: Two formalin-filled containers are received, each labeled with the patient's name, and medical record number.. A. The first container is labeled "A -lipoma." The specimen. consists of four tan-red-white, and cauterized rubbery tissue measuring ranging from 0.7 to 1.6 cm in greatest dimension and 1.8 x 1.5 x 0.8 cm in aggregate. Sectioning reveals yellow-red solid cut surface. Entirely submitted in A1 and A2.. B. The second container is received fresh and subsequently. saved in formalin and labeled "B - left adrenal gland and mass." The specimen consists of a 17 x 8 x 4.9 cm and 171 gm portion of yellow lobulated fibroadipose tissue. The entire external surface is inked black. Sectioning reveals a 7.8 x 5.7 x 4.6 cm yellow-brown solid,
+
+--- Page 4 ---
+ovoid mass. Focal white firm calcifications measuring up to 0.5 cm in greatest dimension is noted in the central area. Also, a 2.5 x 1.5 x 1.3 cm pink and lightly fleshy area is present on the peripheral area of the mass. A purple-red hemorrhage is noted measuring up to 2.5 cm in greatest dimension. Grossly, the mass is entirely encapsulated. On the edge of the mass is a 4.5 x 2.5 x 1.0 cm bright yellow-brown adrenal gland tissue. Representative tissue was procured for potential future studies. The specimen is photographed. Representative sections are submitted. Summary of Sections:. B1 -B3 mass with adrenal gland. B4-B5 - mass to include the pink solid area.. B6 - mass to include hemorrhage.. B7 - mass. 88 - mass to include calcification following fixation and. decalcification. MICROSCOPIC: Microscopic examination is performed.. Sections show a low-grade adrenal cortical carcinoma. The adrenal is  expanded by a 7 cm nodule of eosinophilic cells, many with nucleomegaly and poly-lobation. Tumor is arranged largely in sheets, without trabecular or small cell patterning. The neoplasm is thickly
+
+--- Page 5 ---
+encapsulated, with foci of necrosis. Focally, there is vascular penetration of the capsule; however, the marked margins of resection are free of malignancy. Mitotic activity is inconspicuous. Immunohistochemical stains performed on the tumor show focal immunoreactivity to vimentin. Melan-A is focally positive, with good internal control. There is no immunoreactivity with antibodies to. Pan-Cytokeratin (AE1/AE3). There is weak focal immunoreactivity with antibodies to synaptophysin, but not with antibodies to chromogranin... S-100 highlights normal adipocytes. An antibody to inhibin highlights normal adrenal cortical cells, but does not react with the tumor.
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diff --git a/output/text/cb2f37b6-9494-4a87-8ba6-3b84d144f9b4.txt b/output/text/cb2f37b6-9494-4a87-8ba6-3b84d144f9b4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c9256c1315b3f6a6b96d0ba1c324ab960423f34b
--- /dev/null
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+
+--- Page 1 ---
+UUID:E69389E8-EC63-4B08-BD09-01C663D8B52D TCGA-JY-A93E-01A-PR Redacted Surgical Pathology Consultation Report Patient Name: 4 MRN: Service: Collected: DOB: Visit #: Received: Gender. Location: Reported: Facility: Ordenng MD: Copy To: ID-0-3 Specimen(s) Received 1. Lymph-Node: COMMON HEPATIC NODES ST18 2. Lymph node: Lymph Node Station 20 LnLasnonDNDS 814d13 3. Lymph node: SPLEMIC NODES ST19 4. Lyrmph node:  INF. PULM. LIGAMENT ST9L 5. Lymph node:DIAPHRAGMATIC NODES ST15 Sute lesphage, distal thued.. 6. Lymph node: AORTO-PULMONARY ST5 015.5 7. Lymph node: SUBCARINAL ST.7 8. Lymph node: LT LOW PARATRACHEAL ST4L VJ 4|18J14 9. Lymph node:  ST7 SUBCARINAL NODE 10. Lymph node:  ST16 PARACARDIAL NODE 11. Lymph node: ST 17 LEFT GASTRIC NODES 12. Lymph node: ST8L LOWER PARAESOPHAGEAL LYMPH NODE 13. Lymph node:  ST8M MIDDLE PARAESOPHAGEAL LYMPH NODE 14. Esophagus:  pROXIMAL STOMACH, THORACIC ESOPHAGUS 15. Esophagus: FINAL ESOPHAGEAL MARGIN 16. Soft Tissue:  EEA DONUTS 17. Stomach Resection: PROXIMAL STOMACH FINAL GASTRIC RESECTION MARGIN Diagnosis 1.Lymph-Node: COMMON HEPATIC NODES ST18: - lymph nodes x4: negative for carcinoma 2. Lymph node: Lymph Node Station 20: - lymph nodes x4: negative for carcinoma 3.Lymph node: SPLEMIC NODES ST19: - lymph nodes x4: negative for carcinoma 4. Lymph node:  INF. PULM. LIGAMENT ST9L: - lymph node x1: negative for carcinoma 5.Lymph node:DIAPHRAGMATIC NODES ST15: - lymph nodes x3: negative for carcinoma 6. Lymph node:  AORTO-PULMONARY ST5: - Jymph node x1: negative for carcinoma 7.Lymph node:  SUBCARINAL ST.7: - lymph nodes x3: negative for carcinoma Page 1 of 5
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+Surgical Pathology Consultation Report 8. Lymph node: LT LOW PARATRACHEAL ST4L: - portion of fibroadipose tissue, negative for carcinoma 9. Lymph node: ST7 SUBCARINAL NODE: - lymph nodes x2: negative for carcinoma 10. Lymph nOde:  ST16 PARACARDIAL NODE: - lymph nodes x4: negative for carcinoma 11. Lymph nOde: ST 17 LEFT GASTRIC NODES: - metastatic adenocarcinoma in 1/9 lymph nodes 12.  Lymph nOde:  ST8L LOWER PARAESOPHAGEAL LYMPH NODE: - lymph nodes x5: negative for carcinoma 13. Lymph node: ST8M MIDDLE PARAESOPHAGEAL LYMPH NODE: - lymph nodes x3: negative for carcinoma 14.  Esophagus:  PROXIMAL STOMACH, THORACIC ESOPHAGUS, resection: - adenocarcinoma of distal esophagus, poorly differentiated, involving GE junction and proximal stomach, extending into adventitia -- see synoptic data and comment - metastatic adenocarcinoma in 1/43 lymph nodes (specimens #1 to#13) - resection margins: negative for carcinoma 15.  Esophagus:  FINAL ESOPHAGEAL MARGIN: - negative for carcinoma 16. Soft Tissue: EEA DONUTS - negative for carcinoma 17.  Stomach Resection: PROXIMAL STOMACH FINAL GASTRIC RESECTION MARGIN: - negative for carcinoma. Comment 14. The tumor is a moderately to poorly differentiated adenocarcinoma, centered in the distal esophagus, extending. through GE junction into proximal stomach. The surface of the tumor is ulcerated. The tumor invades adventitia and. is ~ 0.1 cm from the adventitial surface at the closest point. The gastric part of the tumor mainly involves submucosa and muscularis propria with focal extension into perigastric fat. There is metastatic adenocarcinoma in 1/43 lymph nodes. identified. Synoptic Data Clinical History: Not known: . Specimen: Esophagus Proximal stomach Procedure: Esophagogastrectomy Primary Tumor Site: Distal esophagus (lower thoracic esophagus) Additional Sites Involved by Tumor: Esophagogastric junction (EGJ) Proximal stomach and esophagogastric junction Relationship of Tumor to Esophagogastric Junction: Tumor midpoint lies in the distal esophagus and tumor involves the esophagogastric junction Distance of tumor center from esophagogastric junction: 2.0 cm Histologic Type: Adenocarcinoma Histologic Grade: G3: Poorly differentiated Tumor Size Greatest dimension: 3.0 cm Additional dimension: 2.7 cm Page 2 of 5
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+Surgical Pathology Consultation Report Additional dimension: 1.0 cm Microscopic Tumor Extension: Tumor invades through the muscularis propria into the periesophageal soft tissue (adventitia) Proximal Margin: Uninvolved by invasive carcinoma. Uninvolved by dysplasia Distal Margin: Uninvolved by invasive carcinoma. Uninvolved by dysplasia Circumferential (Adventitial) or Deep Margin: Uninvolved by invasive carcinoma. All Margin Status All margins uninvolved by invasive carcinoma. Distance of invasive carcinoma from closest margin: 1.0 mm. Closest margin: Circumferential Treatment Effect: No prior treatment Lymph-Vascular Invasion: Present Perineural Invasion:. Present TNM Descriptors: Not applicable: . Primary Tumor (pT): pT3: Tumor invades adventitia Regional Lymph Nodes (pN): pN1: Regional lymph node metastasis involving 1 to 2 nodes. Number of regional lymph nodes examined: 43. Number of regional lymph nodes involved: 1 Distant Metastasis (pM): Not applicable: Additional Pathologic Findings: *None identified *Pathologic Staging is based on AJCC/UICC TNM, 7th Edition Electronically verified by: Clinical History ESOPHAGEAL CA Gross Description 1. The specimen container is labeled with the patient's name and as "Lymph Node: Common hepatic nodes ST18". consists of multiple pieces of fatty tissue measuring in aggregate 2.3 x 2.3 x 0.7 cm received in 10% buffered formalin.. Within the fatty tissue, multiple lymph nodes are identified measuring from 0.2 to 0.8 cm. The specimen is submitted in toto as follows 1A- multiple lymph nodes. 1B- remainder of fatty tissue. 2. The specimen container is labeled with the patient's name and as "Lymph Node: Lymph node station 20" consists of multiple pieces of fatty tissue measuring from0.3 x 0.2 x 0.2 to 1.2 x 0.7 x 0.5 cm received in 10% buffered formalin. 2A- submitted in toto. 3. The specimen container is labeled with the patient's name and as "Lymph Node: Splenic nodes ST19" consists of. multiple pieces of fatty tissue measuring in aggregate 1.7 x 1.5 x 0.5 cm received in 10% buffered formalin.. 3A-submitted in toto. 4. The specimen container is labeled with the patient's name and as "Lymph Node: Inferior pulmonary ligament ST9L' consists of two fragments of fatty tissue measuring 1.5 x 0.3 x 0.5 cm and 1.7 x 0.8 x 0.4 cm received in 10% buffered formalin. 4A- submitted in toto. 5. The specimen container is labeled with the patient's name and as "Lymph Node: Diaphragmatic nodes ST15" consists of 3 pieces of fatty tissue measuring from 0.5 x 0.3 x 0.2 cm to 3.5 x 1.5 x 0.7 cm received in 10% buffered formalin.. Page 3 of 5
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+Surgical Pathology Consultation Report 5A-5B- submitted in toto 6. The specimen container is labeled with the patient's name and as "Lymph Node: Aorto- pulmonary ST5" consists of a fragment of yellow-brown tissue measuring 0.7 x 0.6 x 0.4 cm received in 10% buffered formalin. 6A- submitted in toto. 7. The specimen container is labeled with the patient's name and as "Lymph Node: Subcarinal ST7" consists of 3 pieces of yellow black tissue measuring from 0.7 x 0.3 x 0.1 cm to 0.8 x 0.5 x 0.4 cm received in 10% buffered formalin. 7A- submitted in toto 8. The specimen container is labeled with the patient's name and as "Lymph Node: LT Low Paratracheal ST4L" consists. of a fragment of yellow-brown tissue measuring 1.0 x 0.5 x 0.3 cm received in 10% buffered formalin. 8A- submitted in toto. 9. The specimen container is labeled with the patient's name and as "Lymph Node: ST7 Subcarinal Node" consists of a piece of black-brown tissue measuring 3.9 x 2.7 x 1.2 cm received in 10% buffered formalin. 9A-9B- specimen is bisected and submitted in toto.. 10. The specimen container is labeled with the patient's name and as "Lymph Node: ST16 Paracardial node" consists of a. piece of fatty tissue measuring 5.5 x 3.4 x 1.0 cm received in 10% buffered formalin. Within the fatty tissue, multiple lymph nodes are identified measuring from 0.5 cm to 1.2 cm. The specimen is submitted in toto as follows: 10A- multiple lymph nodes 10B-10C-remainder of fatty tissue. 11. The specimen container is iabeled with the patient's name and as "Lymph Node: ST17 left gastric nodes" consists of a. piece of fatty tissue measuring 4.0 x 3.8 x 2.7 cm received in 10% buffered formalin. Within the fatty tissue, multiple lymph nodes are identified measuring from 0.5 cm to 2.4 cm. Representative sections are submitted as follows: 11A- multiple lymph nodes. 11B-11C- one lymph node bisected. 11D-11H- fatty tissue. 12. The specimen container is labeled with the patient's name and as "Lymph Node: ST8L lower paraesophageal lymph node" consists of a piece of fatty tissue measuring 4.0 x 4.0 x 1.5 cm received in 10% buffered formalin. Within the fatty tissue, multiple lymph nodes are identified measuring from 0.3 to 0.6 cm. The specimen is submitted in toto as follows:. 12A-multiple lymph nodes. 12B-12E- remainder of fatty tissue. 13. The specimen container is labeled with the patient's name and as "Lymph Node: ST8M middle paraesophageal lymph node" and consists of a piece of fatty tissue measuring 4.0 x 3.5 x 0.7 cm received in 10% buffered formalin.Within the fatty tissue, two lymph nodes are identified measuring 0.5 x 0.3 x 0.2 cm and 0.7 x 0.5 x 0.2 cm. The specimen is. submitted in toto as follows: 13A- two lymph nodes 13B-13D- remainder of fatty tissue 14. RESECTION SPECIMEN: Esophagus: Proximal stomach, thoracic esophagus (gastro esophagectomy) FIXATION: Fixed DIMENSIONS: Stomach: Length along lesser curvature:  4.4 cm Length along greater curvature:  3.5 cm Circumference of distal gastric margin: 11.0 cm. Esophagus: : : Length of tubular esophagus: 6.9 cm Width of tubular esophagus: 4.0 cm TUMOR Page 4 of 5
+
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+Surgical Pathology Consultation Report LOCATION: - GE junction tumor - 60% of tumor mass located in the esophagus and 40% of the tumor mass located in the proximal stomach - CONFIGURATION: Polypoid and ulcerated - DIMENSIONS: Diameters:3.0 x 2.7 cm Depth:1.0 cm - DESCRIPTIVE CHARACTERISTICS: Tan-brown ulcerated tumor mass with irregular heaped up edges - PERFORATION: No - DISTANCE FROM MARGINS: - PROXIMAL: 3.4 cm - DISTAL: 1.8 cm - RADiAL: 0.1 cm (nonperitonealized soft tissue margin closest to deepest tumor penetration). ESTIMATED DEPTH OF INVASION: Adventitia LESIONS IN NONCANCEROUS STOMACH: None grossly LYMPH NODES: No perigastric lymph nodes along the greater and lesser curvatures are identified from the specimen Tissue stored frozen Representative Sections: 14A- proximal esophageal margin en face 14B-14M- tumor submitted in toto, proximal to distal 14N- proximal esophagus 14O- distal gastric margin en face. 14P- gastric wall 14Q- perigastric fat 15. The specimen container is labeled with the patient's name and as "Esophagus: Final esophageal margin consists of a piece of tan-brown tissue with one stapled edge measuring 1.8 x 0.7 x 0.7 cm received in 10% buffered formalin.. 15A- submitted in toto after removal of the stapled line 16. The specimen container is labeled with the patient's name and as "Soft Tissue: EEA donuts" consists of a piece of tan-brown tissue measuring 2.3 x 1.0 x 0.8 cm received in 10% buffered formalin.. 16A- submitted in toto. 17. The specimen container is labeled with the patient's name and as "Stomach Resection: Proximal stomach final gastric. resection margin" consists of a portion of stomach with one stapled line measuring in 6.5 by 4.0 x 2.8 cm received in 10% buffered formalin. The stapled line margin is removed. Upon opening of the specimen, the gastric mucosa is tan-brown in color and is grossly unremarkable. Representative sections are submitted as follows:. 17A-17C- stapled line margin en face. 17D-17E- gastric wall. hJ 13f18113
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diff --git a/output/text/cb8bde02-f4b1-476d-b257-2894d3a2c9d3.txt b/output/text/cb8bde02-f4b1-476d-b257-2894d3a2c9d3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fc99b2d78234d1e440c0f3f2ceccd3590b7ed588
--- /dev/null
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+
+--- Page 1 ---
+DIAGNOSIS (A) CONTENTS OF RIGHT NECK DISSECTION: METASTATIC SQUAMOUS CARCINOMA IN 1 OF 1O RIGHT LEVEL III LYMPH NODES. Three lymph nodes, no tumor, level II, right side.. Six lymph nodes level Iv right side, no tumor present.. Five lymph nodes level V, no tumor present.. B) CONTENTS OF LEFT NECK DISSECTION: METASTATIC SQUAMOUS CARCINOMA IN 3 OF 6 LEFT LEVEL II LYMPH NODES. METASTATIC SQUAMOUS CARCINOMA IN 2 OF 9 LEFT LEVEL III LYMPH NODES METASTATIC SQUAMOUS CARCINOMA IN 3 OF 4 LEFT LEVEL IV LYMPH NODES. Two lymph nodes left level v 1ymph nodes, no tumor. TOTAL LARYNGECTOMY AND PARTIAL PHARYNGECTOMY: POORLY DIFFERENTIATED NON-KERATINIZING SQUAMOUS CARCINOMA OF RIGHT PYRIFORM SINUS MEASURING 3.5 X 1.5 X 1.3 CM INVOLVING LATERAL WALL OF LARYNX WITHOUT INVASION OF BONE. MARGINS OF RESECTION ARE FREE OF TUMOR. Vocal scar with edema.. Inflammation and fibrosis, no tumor.. (D) TEETH: Teeth (gross diagnosis only).. GROSS DESCRIPTION A) CONTENTS OF RIGHT NECK DISSECTIONLEVEL 2 -A 2.5 x1.5 x 0.3 cm pink-yellow fragment of adipose tissue. Level 3 (4.0 x 2.0 x 1.0 cm). Level 4 (2.5 x 1.2 x 0.4 cm) and 1eve1 5 (8.5 x 2.8 x 0.6 cm). SEcrIoN coDE: A1, one 1ymph node from level 2; A2, one lymph node from level 2; A3, one section lymph node from leve7 2;A4,_1 1ymph node from level 3A5,5 1ymph nodes from 1evel 3;A6,4 1ymph nodes from 1evel 3A74 1ymph nodes from level 4; A8, 3 1ymph nodes from level 4 A9, 4 1ymph nodes'from level 5; A10, 1 lymph node from level 5. B)CONTENTS OF LEFT NECK DISSECTION  SeveraT pink-yellow fragments of adipose tissue with lymph nodes; level 2 (4.5 x 3.2 x 2.2 cm) with several enlarged lymph nodes, the largest of which measures 3.2 cm in greatest dimension and contains metastatic carcinoma; level 3 (4.0_x 3.0 x 2.0 cm) which contains a 3.0 cm grossly positive lymph node as well as additional lymph nodes, levels 4 (4.5 x 3.5'x 2.0 cm) contains three grossly positive. 1ymph nodes, the largest of^ which measures 2.9 cm in greatest dimension, Teve7. 510.0 x 2.0 x0.6 cm) with severa1 1ymph nodes. SEcTION coDE: B1, 1 bisected 1ymph node from level 2; B2, 3 1ymph nodes from level 2; B3, 1 bisected lymph node from level 2; B4, a portion of grossly Page 1 of 2 History Case Pathology Report History  Case Pathology File under: Pathology
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+--- Page 2 ---
+positive 1ymph node from Tevel 2B5,portion of another grossly positive Tymph node from 1eve1 2B6fragment ofgrossly positive1ymph node from 1eve13B75 1ymph nodes from 1eve13B831ymph nodes from 1eve13B9 fragment of grossly positive lymph node from 1evel 4B10fragment of another grossly positive 1ymph node from level4B11,fragment of another grossly positive1ymph node from level 4B12one 1ymph node from 1evel 4B133 lymph nodes from 1evel 5. C)TOTAL LARYNGECTOMY AND PARTIAL PHARYNGECTOMY -.A tota1 laryngectomy and partial pharyngectomy with overa11 measurement of 10.0 x 7.0 x 4.5 cm. A fungating and ulcerated lesion located in the left pyriform sinus measures 3.5 x 1.5 x 1.3 cm is noted. The tumor penetrates the soft tissue but does not destroy the bone. The mucosal surface appears grossly uninvolved. The right. and left transglottic cords are unremarkable.. SEcTion coDe: c1-c4, tumor; c5,_right transglottic cord; C6, left transglott cord; c7-c19, sequential of mucosa and tumor from left to. right. *FS/DX: MUCOSAL MARGIN, FREE. D TIPS- from1.5x0.4x0.3cm to2.3 x0.8x0.4 cm. Areas of black discoloration are noted on the tip of the tooth surface. The. specimen is for gross only. Page 2 of 2 History Case Pathology Report History Case Pathology File under: Pathology.
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diff --git a/output/text/cb8fce3f-44d0-46dd-8606-1ed373c13e86.txt b/output/text/cb8fce3f-44d0-46dd-8606-1ed373c13e86.txt
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index 0000000000000000000000000000000000000000..4752890aeeb6d64c9e52e205dfdcb8296c0b2ac1
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+Procedure Date: Procedure Physician: Sit: Brest Nos C 50.9 8503/3 Attending Physician/Copies To. 1/2/ h PATIENT HISTORY: UUID:A23755DD-00C4-4349-8E11-C1196E8C91D3 + DATE OF LMP: + TCGA-BH-A1EO-01A-PR Redacted DATE OF LAST DELIVERY: PRE-OP DIAGNOSIS: RT BREAST CANCER POST-OP DIAGNOSIS: SAME OPERATIVE PROCEDURE: RT SEC MASTECTOMY, RT CX NODE DISSECTIONS CLINICAL HISTORY: MATERIAL SUEMITTED: A)(RIGHT)BREAST BIOPSY/MASS/SEGMENTAL MASTECTOMY, PROCUREMENT BY SURGICAL PROCEDURE B) RIGHT AXILLARY CONTENTS INTRAOPERATIVE CONSULTATION: FRozen secrion: Right breast: 2 masses, 1.0 by 1.5 by 1.2 cm 0.4 cmt from medial margin. Other 1.5 by 1.0 by 1.5 cm 0.5 cm from superior margin. Frozen section diaynosis... lobular carcinoma. FINAL DIAGNOSIS: PREVIOUS REdORT: AGAFS) RIGHT BREASTSEGMENTAL MASTECTOMY: BY 1.2 BY1.0 CM FOCAL DUCTAL CARCINOMA IN SITU, NON-COMEDO TYPE, COMPRISING <5t OF TUMOR B) RIGHT AXILLARY CONTENTS: - ONE J1) OF FIFTEEN (15) NODES POSITIVE FOR TUMOR AND SHOWING EXTRA CAPSULAR EXTENSION ER/PR My signature below is attestation that I have reviewed all slides and agree with the findings as noted below. IMMUNOPEROXIDASE IDENTIFICATION OF (ESTROGEN AND PROGESTERONE RECEPTORS)IS CARRIED OUT _ON SLIDE A1. DISTINCT INTRANUCLEAR STAINING IS IDENTIFIED FOR BOTH ESTROGEN RECEPTOR (9O$) AND PROGESTERONE RECEPTOR (9OS). THEREFORE, BOTH ARE INTERPRETED AS POSITIVE. Pathologist JPPLEMENTALREPORT HER-2/NEU My signature below is attestation that I have reviewed all slides and agree with the tindings as noted below. C-erbB2 (HER-2/NEU) IMMUNOSTAINING IS CARRIED OUT ON BLOCK A1 (BREAST CANCER) USING A 1:3OO DILUTION OF DAKO'S POLYCLONAL ANTIBODY A485 (DIRECTED AGAINST THE INTRACELLULAR DOMAIN OF C-erbB2) WITHOUT ANTIGEN RETRIEVAL. NO DISTINCT COMPLETE MEMBRANE STAINING IS IDENTIFIED. THEREFORE, C-erbB2 (HER-2/NEU) IS INTERPRETED AS NEGATIVE (SCORE O).
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diff --git a/output/text/cbaf0fcb-4a5b-4c16-b851-dc110975af0c.txt b/output/text/cbaf0fcb-4a5b-4c16-b851-dc110975af0c.txt
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index 0000000000000000000000000000000000000000..9da15ea84f4e852a573505208f4145c401a370a3
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+Formatted Path Report LARGE INTESTINE TISSUE CHECKLIST Specimen type:  Excision of tumor Specimen size: Not specified Tumor site: Colon Tumor size: 5 x 5 x 0.8 cm Tumor features: None specified Histologic type: Adenocarcinoma Histologic grade: Moderately differentiated Tumor extent: Subserosa Lymph nodes: Not specified Margins: Not specified Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None
+
+--- Page 2 ---
+Date of Procurement
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diff --git a/output/text/cbe5d34b-59bc-4815-971a-4257f5c8050b.txt b/output/text/cbe5d34b-59bc-4815-971a-4257f5c8050b.txt
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index 0000000000000000000000000000000000000000..58340ba1bab21ae9a59fc355c78a65dcf5117bb9
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+
+--- Page 1 ---
+FINAL DIAGNOSIS: Part 1: Right Sentinel Lymph nOde #1, BiOpsy - One Lymph nOde NEgATiVE fOR TUMOR (0/1). Part 2: Right nonsentinel Lymph node, BiOpsy- ONE LYMPH NODE NEGATIVE FOR TUMOR (0/1). Part 3: Right breast, Lumpectomy --- INFILTRATING.DUCI CARCiNOMA. 0.9 X 0.8 X 0.6 Cm. B. NOTTINGHAM SCORE 6/9 (TUBULES 3, NUCLEI 2, MITOSIS 1) C.  NO LYMPHOVASCULAR INVASION IDENTIFIED. D. DUCtAL CARCINOMA In SITU, SOLiD TyPE, nUCLEAR GRADE 2, COMpRISiNg 5% OF InVaSiVe TUmOR. E.  SURGICAL MARGINS NEGATiVE FOR iNFILTRATING DUCT CARCINOMA AND DUCTAL CARCINOMA IN SITU. F. CHAnGES CONSISTENT WITH PREVIOUS CORE BIOPSY SITE. G.  TUMOR IS ESTROGEN RECEPTOR POSITIVE, PROGESTERONE RECEPTOR POSITIVE AND HER-2/NEU WEAKLY POSITIVE (SCORE 2+). NO AMPLIFICATION OF HER-2/NEU GENE WAS IDENTIFIED. H.FiBROCySTic Changes wITh mIcrocalCIFIcATiONS. CASE SYNOPSIS: SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST Icd-0 -3 LATERALITY: Right PROCEDURE: LOCATION:  Segmental S#: brenot, Nos C50.9 3/131n h Not specified SIZE OF TUMOR:  Maximum dimension invasive component: 0.9 cm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: TUMOR TYPE (invasive component): No NOTTINGHAM SCORE: Ductal adenocarcinoma, NOS Nuclear grade: 2 Tubule formation: 3 UUID:11E1BCE2-F246-4930-A97C-A14834BCF840 TCGA-BH-A0B8-01A-PR Mitotic activity score: 1 'Redacted Total Nottingham score: 6 Nottingham grade (1, 2, 3): 2 ANGIOLYMPHATIC INVASION: DERMAL LYMPHATIC iNVASION: No  Not applicable CALCIFICATION: No Tumor type, in situ: Solid, Percent of tumor occupied by in situ component: 5 % SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: SURG MARGINS INVOLVED BY IN SITU COMPONENT: No LyMPh nOdES POSITIVE: No LYMPH NODES EXAMINED: 0 METHOD(S) OF LymPh NODE EXAMInATION: 2 H/E stain SENTINEL NODE METASTASIS: SIZE OF nODaL mETASTASES: No Diameter of largest lymph node metastasis: 0 mm NON-NEOPLASTIC BREAST TISSUE: FCD t stage, pathologic: N Stage, pathologIC: pT1b m stage, pathologIc: pN0 ESTROGEN RECEPTORS: pMX PROGESTERONE RECEPTORS: positive HER2/NEU: positive 2+ Diagnosis  3413/11
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diff --git a/output/text/cbf00430-2e14-410d-92f2-fededfa1f075.txt b/output/text/cbf00430-2e14-410d-92f2-fededfa1f075.txt
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index 0000000000000000000000000000000000000000..5c04470dce87fa24c9c0a803c2bd1b515b791bd0
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+
+--- Page 1 ---
+UUID:D346F4E5-4E4A-4161-96FB-7B8ABBB171283 CGA-E9-A5FK-01A-PR Redacted Gross Description: There is a breast with tumor up to 2.5 cm in size. In the fatty tissue there are dense hyperemic metastatic lymph nodes up to 2 cm in size. Microscopic Description: Infiltrating lobular carcinoma of the breast, G-2, with scirrhous type of growth. Ten examined lymph nodes demonstrated metastases. IHC-staingins: ER - positive reaction 85% 3+; PR - positive reaction 70% 3+; Her-2/neu - negative reaction; Ki-67 - 18%. Diagnosis Details: Tumor Features: Indeterminate, Tumor Extent: T2 tumor size more than 2cm not more than 5 cm, Venous Invasion: Absent, Margins: Absent, Treatment Effect: Comments: TCD-0-3 Formatted Path Reports: BREAST TISSUE CHECKLIST Qrcncrie, in F, Itratrg. Specimen type: Radical mastectomy. Lobular 8s20/3 Specimen size: Not specified Si+e:@Breast xsS C5o y Tumor site: Breast QS /o/i3 Tumor size: 0 x 0 x 2.5 cm Grossly evident lesion: Yes Histologic type: Lobular carcinoma. Histologic grade: Moderately differentiated Tumor extent: Not specified Lymph nodes: 10/10 positive for metastasis (Axillary 10/10) Extracapsular invasion of the lymph nodes: Not specified Margins: Uninvolved. Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified.
+
+--- Page 2 ---
+Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified. Additional pathologic findings: ER - positive reaction 85% 3+; PR - positive reaction 70% 3+; Her-2/neu negative reaction; Ki-67 - 18%. Comments: Right AA
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diff --git a/output/text/cbffd865-e74d-4355-8d6a-9af293675bca.txt b/output/text/cbffd865-e74d-4355-8d6a-9af293675bca.txt
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index 0000000000000000000000000000000000000000..15c8e5111e22cf200bcd8ce54ca0c4ddc1313410
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+
+--- Page 1 ---
+Diagnosis: Ileocolic resection material includes a centrally ulcerated, moderately differentiated adenocarcinoma of the colorectal type in the region of the right flexure, with a maximum diameter of 4.5 cm with incipient infiltration of the pericolic fatty tissue (max. infiltration depth in fatty tissue less than 1 mm in the histological section). Tumor-free regional lymph nodes. Tumor-free resection margins of small intestine and colon. Three tubular colon mucosa adenomas with mild to moderate dysplasia (synonym: low-grade intraepithelial neoplasia). Tumor stage: pT3 pN0 (0/24) pMX; G2, L0, V0, R0
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diff --git a/output/text/cc1679a0-01af-4bb1-82aa-095be1c2f85b.txt b/output/text/cc1679a0-01af-4bb1-82aa-095be1c2f85b.txt
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index 0000000000000000000000000000000000000000..6db235232dd0c7d18a1ebe79dc426e36a71722fa
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+
+--- Page 1 ---
+Patient Name Accession #: Med. Rec. #: Dale of Procedure DOB: Date of Receipt. Gender: Date of Report. Ref. Physician. Account #: Patient Address: Billing Typo Additional Copy to Ref Source: Clinical Diagnosis & History: Patient with teft renal mass history of DM, obesity. HTN Specimens Submitted: 1: SP: Kidney, left, radical nephrectomy 2: SP: Lymph nodes, para-aortic and preaonic, excision 3: SP: Adrenal and suprahilar lymph nodes, Lelt , resecti DIAGNOSIS: 1.Sp: Kidney, left, radical nophrectomy . Two discrete tumor masses are identified:. a. High grade renal cell carcinoma with extonsive tubular and tubulopapillary architecture, favored to be a tumor of distal nephron origin; sec comment. - The tumor measures 7.1 cm - Local invasion: nol identified - Renal vein invasion: not identified - Surgical margins: free of tumor. - Adrenal gland: not identified (see Part 3). - Lymph nodes: not identified  Non-neoplastic kidney: unremarkable - Pathologic Stage: pT2 (tumor > 7.0 cm in grealost dimension limited to the kidney) Comnent: The tumor demonstrates marked cylologic atypia in the form of nucleo- and nucleolomegaly, as well as focal. desmoplasia. Immunohistochemical stains are positive for CK7 (focal, strong). Racemase (diffuse, strong). c-kit (patchy,  moderale). and CA-IX (focal, weak), while negative for 34BE 12. Although the growth paltern of this tunor is unusual, its. tible with a distal nephron/collecting ducl tumor. This case has been reviewed with th. ich concurs with the diagnosis b. Renal cell carcinoma, clear cell (conventional) typeuhrman nuclear grade II/IV - The iumor measures 2.6 cm - Local invasion: tumor invades through tho renal capsule but is confined within Gerota's fascia. . Renal vein invasion: not identified Surgical margins: free of tumor - Adrenal gland: not identitied (see Part 3). - Lymph nodes: not identified . Non-neoplastic kidney: unremarkable. - Pathologic Stage: pT3 (tumor invades peri-nephrc tissues but not beyond Gerota's fascia ). 2. SP: Lymph nodes, para-aortic and preaortic, excision Lymph Nodes: Not involved Number of nodes examined:15 3. SP: Adrenal and suprahilar lymph nodes, left, resectior Benign adrenal gland. Page 1 of 3
+
+--- Page 2 ---
+No lymph nodes identified.. TATTEST THAT THE ABOVE DIAGHOSIS I$ BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (ANDIOR OTHER MATERIAL), AND THAT I HAVE REVIEWEDAND APPROVED THIS REPORT. Speclal Studies: Result Special Stain Comment RECUT CK7 RACEMASE 34RE12 CA-1X. CD117 NEG CONT IMM RECUT Gross Description: 1). The specimen is received tresh labaled "lell kidney" and consists of a kidney with attached ureter, renal vessels and perinephric tat weighing 1174 g in total. The entire specimen measures 25 x 13.5 x 7.5 cm. The kidney measures 13.5 x 6 x 5.5 cm. The attached ureter measures 7.5 cm in length and 2.4 cm in diameter.. The attached renal vein measures 0.9 cm in diameter. The. renal vessels and ureter margins are grossly unremarkable. No adrenal gland identified. The kidney is inked black and bivalved to. reveal two masses. The first mass is a well-circumscribed white tan mass arising fron the middle pole of the kidney measuring 7.1 x 7 x 3.2 cm. The mass shows areas of necrosis and hemorhage. The mass is partially encapsulated and is abutting the pelvis. but does nol grossly involve it. The mass appears to bulge into the perirenal fat but appears to be contained within the capsule.. There is no gross extension into the perihilar fat. The second mass is tocated in the lower polo of the kidney, measuring 2.6 x 2 x 1.6 cm, the mass is yellow orange and lobulated, and appears to invade the perirenal fat. Seclions through Ihe remainder of the. kidney reveal a pink brown parenchyma, with a well-dofined cortico-medullary junction. The cortex measures O.7 cm and the calyces appear normal. No lymph nodes are identified in the perinephric tat. The specimen is photographed. Representative seclions are submilted for IPS and for permanent sections.. Summary of seclions.. UVM -- ureterat and vessel margins TU--tumor THF-- (umor with hilar fal. THS -- tumor with sinus fat. TK -- tumor with adjacent kidney TP.- tumor to renal pelvis K -- uninvolved kidney  M2 -- representativo seclion of the second mass M2F - second mass wilh perirenal fat ADDm2 - additional second mass with radial margin. 2). The specimen is received in formalin labeled "paraortic and preaortic lymph nodes" and consists of mulliple pinx tan fatty lymph nodes wilh altached falty fibrous tissue ranging from 0.3 cm up to 2.2 cm in greatest dimension. Allidentifiod lymph nodes are. submitled. Summary of seclions:. LN1- sectioned largest lymph node BLN-bisecled lymph nodes tN-lymph nodes Page 2 of 3
+
+--- Page 3 ---
+2). The specimen is received fresh labeled "lelt adrenal and suprahilar lymph nodes'. The specimen consisls of the adrenal gland with surrounding adipose tissue weighing 70 g, and measures 10 x 5 x 3.5 cm. The entire outer surface is inked blue.  The specimen is serially sectioned and shows unremarkable parenchyma, wilh thin yellow orange cortex and brown medulla. No grossly identifiable tesion. Representative sections of the adrenal giand are submitled. Possible lymph nodes are submitted. Summary ol sections:. A-adrenal gland  PLN -- possible lymph nodes. Summary ot Sections:. Part 1: SP: Kidney, left, radical nephrectomy Block Sect. Site PCs ADDM2 1 1 K 1 2 M2 2 M2F 1 1 THF 1 1 THS 1 TK 1 TP N  5 TU 1 UVM 1  Part 2:  $P: Lymph nodes, para-aortlc'and preaortic, excision Block Sect. Site pCs 5 bln 5 4 in 4 3 In1 3 Part 3: SP: Adrenal and suprahilar lymph nodes, Left , rosectior Block Sect. Site PCs 2 A 2 2 PLN 2 Page 3 of 3 END OF REPORT
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diff --git a/output/text/cc5e6699-f891-4acb-84a9-75f218af4374.txt b/output/text/cc5e6699-f891-4acb-84a9-75f218af4374.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a1534906bf6aa58fae7a16b74c1f921a183fddc3
--- /dev/null
+++ b/output/text/cc5e6699-f891-4acb-84a9-75f218af4374.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+RUN DATE: RUN TIME: PAGE 1 RUN USER: PATIENT: ACCT #: AGE/SX: REG DR:  ROOM: DOB: BED:. STATUS: SPEC #: RECD : STATUS : COLL : TIME IN FORMALIN: 6:29 hrs. Addondun # 1 A typographical error is present on ths initial synoptic report in the comment field on the original report. The histologic type of the invasive carcinoma should be stated as invasive lobular carcinoma (pleomorphic type). Addendum Signed (signature on file). UUID:D318A0F0-38B2-4DFA-8326-E362603AAC5E TCGA-LL-A6FP-01A-PR Redacted tgD -O 3 I Nos J$520/B 0 RBuusFuos Cso.9 JV sJ1dh 3 ** CONTINUED ON NEXT PAGE **
+
+--- Page 2 ---
+PAGE 2 RUN DATE RUN TIME RUN USER (Continued) SPEC #: CLINICAL INFORMATION: Pre-Op Diagnosis: Right breast cancer Remarks: Specimen(s) : Right breast. stitch on axillary tail. MICROSCOPIC DIAGNOSIS RIGHT BREAST. MASTECIOMY: INVASIVE LOBULAR CARCINOMA. PLEOMORPHIC TYPE MODIFIED NOTTINGHAM HISTOLOGIC GRADE 2 OF 3, NUCLEAR SCORE 2 OF 3. TUBULAR FORMATION SCORE 3 OF 3. MITOTIC SCORE 1 OF 3 (3 MITOTIC FIGURES PER TUMOR MEASURES 3.5 CM SURGICAL MARGINS FREE OF TUMOR WITH NEAREST MARGIN THE DEEP MARGIN AT 1 MM FROMS TUMOR SEE COMMENT FOR SYNOPTIC REPORT COMMENT(S) SURGICAL PATHOLOGY CANCER CASE SUMMARY - APPROVED BY COLLEGE OF AMERICAN PATHOLOGISTS Total mastectomy PROCEDURE: .. SPECIMEN LATERALITY: Right Invasive.. ductal.. carcinoma HISTOLOGIC TYPE OF INVASIVE CARCINOMA: Greatest dimension of largest focus of invasion: TUMOR SIZE: 39 mm Glandular/tubular differentiation: score 3 HISTOLCGIC GRADE: Nuclear pleomorphism: score 2 Mitotic rate: score 1 Overall grade: grade 2 TUMOR FOCALITY: Single focus of invasive carcinoma. No DcIs is present DUCTAL CARCINOMA IN SITU: MARGINS : Invasive carcinoma: Margins uninvolved by invasive carcinoma Distance from closest margin: 1 mm. deep Total number of lymph nodes examined: 0 LYMPH NODES: Primary tumor: pT2 PATHOLOGIC STAGING: Regional lymph nodes: pNX Distant metastasis: not applicable Estrogen receptor: ANCILLARY STUDIES: Results: positive (loo% of tumor cells with nuclear positivity) Progesterone receptor: Results: positive (21% of tumor cells with nuclear positivity) HER-2:  Immunoperoxidase studies Results: equivocal (score 2+) ** CONTINUED ON NEXT PAGE **
+
+--- Page 3 ---
+ RUN DATE RUN TIME PAGE 3 RUN USER SPEC #: (Continued) COmmENT(S) (Continued) In situ hybridization (Fish): not amplified GROSS DESCRIPTION: Received fresh for tissue banking labeled with the patient's name and "right breast" is a. 257 gram. 18.0 x 16.0 x 3.0 cm fibrofatty breast. The breast has an overlying 16.0 x 12.0 cm tan-white skin ellipse with an eccentric 3.0 cm areolar and flattened 1.0 cm nipple. No scars are identified on the skin surface. The specimen is oriented with a suture at the axillary tail. The deep margin has a smooth fascial plane with no significant strands of fibroskeletal muscle. The breast is consistent with a simple mastectomy spacimen. The deop margin is inked blue. and the breast is serially sectioned from lateral to medial to have a central. lobulated. dense indurated tumor mass with fibrous septae. The mass. focally ranges up to 3.9 cm and is 3.9 x 3.6 x 2.6 cm. Tho tumor is 0.2 cm from the deep margin, and the deep margin appears to slide freely over the tumor mass. The mass is 2.3 cm from the superior margin. is 5.8 cm from inferior. is 5.6 cm from lateral and 7.4 cm from medial. There is diffuse surrounding dense white fibrous tissue. closely associated with the upper outer quadrant. Ths dense white fibrous tissue makes up The tumor is most. approximately 60% of the parenchyma. A section of the tumor is sampled for tissue banking. No additional lesions are identified. Representative sections are sampled as labeled:. 1 perpendicular section of nipple 2-3 tumor to nearest deep margin 4 additional section of tumor 5 upper outer quadrant sampled (quadrant nearest tumor) 6 lower outer quadrant sampled 7 upper inner quadrant sampled 8 lower inner quadrant sampled INTRAOPERATIVE CONSULTATION: IMMEDIATE GROSS EVALUATION (RIGHT BREAST) : INVASIVE CARCINOMA. PROCESSED FOR TUMOR BANKING SURGICAL MARGINS FREE OF TUMOR PHOTO IOXUMENTATION Image Signed (signature on file). ** END OF REPORT ** Criter 1233
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diff --git a/output/text/cc841e9a-bf42-4850-9c24-525fc778db6d.txt b/output/text/cc841e9a-bf42-4850-9c24-525fc778db6d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..58717c9b56da9e094719d2bc5bf8a5b79cdfad4c
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Page 1 of 2 Final Pathologic Diagnosis RIGHT KIDNEY (LAPARQSCOPIC NEPHRECTOMY): Renal cell carcinoma, papillary type (8.0 cm), Fuhrman nuclear grade 3 (See synoptic report).. Note: The case was discussed In the on at  and reviewed in conjunctlon with one or more attending pathologists in this department who concur(s) with the above diagnosis.. I attest I have personally reviewed the specimen/slides and agree with the above findings. Electronic Signature IcD -O-3 Verified: 8 Qsf3 Resident: Site, Kdoney NoS 164.9 Synoptic Report. A: KIDNEY, NEPHRECTOMY SPECIMEN TYPE: Radical nephrectomy LATERALITY: UUID:4043D1BE-FCA1-4613-B304-2B490FCBB6B9 TCgA-V9-A7ht-01A-PR Redacted Right *TUMOR SITE: *Upper pole FOCALITY:  Unifocal TUMOR SIZE (largest tumor if multiple): Greatest dimension: 8.0 cm. *Additional dimensions: 7.1 x 5.3 cm MACROSCOPIC EXTENT OF TUMOR: Tumor limited to kidney HIStOLOGIC Type: Papillary renal carcinoma HISTOLOGIC GRADE (Fuhrman Nuclear Grade): G3: Nuclei very irregular, ~20 microns; nucleoli large and promienent. PRIMARY TUMOR (pT)PRIMARY TUMOR (pT): pT2: tumor more than 7 cm in greatest dimension, limited to the kidney. REGIONAL LYMPH NODES: pNX: cannot be assessed DISTANT METASTASIS (pM): pMX: Cannot be assessed  MARGINS:  Margins uninvolved by invasive carcinoma ADRENAL GLAND:
+
+--- Page 2 ---
+Page 2 of 2 Not present *VENOUS (LARGE VESSEL) INVASION (V) (excluding renal vein and inferior vena cava): *Absent *LYMPHATIC INVASION (L): *Absent *ADDITIONAL PATHOLOGIC FINDINGS:E *Inflammation (type): chronic *COMMENT(S): - The tumor exhibits histologic features of type-2 papillary renal cell carcinoma. Clinical History Not provided. Pre/Post-operative Diagnosis Not provided. Gross Anatomic Descrintion (Dictated by : . Reviewed by on Specimen received in one container. Specimen: Designated "right kidney" is received in formalin labeled with the patient's name, MRN and "right kidney". A small piece of the mass was submitted for. Specimen consists of a right total nephrectomy weighing 284 g and measuring 12.2 x 6.7 x 6.2 cm. There is a portion of pericapsular fat around the hilum, superior pole and inferior pole measuring 0.5 cm in thickness. Extending from the renal pevis are a ureter (1.0 cm in length and 0.2 cm in diameter), renal artery (0.9 cm in length and 0.2 cm in diameter) and the renal vein cannot be definitely identified. Tumor does not extend into the ureter I artery and is not present at the resection margin. There is a 8.0 x 7.1 x 5.3 cm well circumscribed, solid, yellow/tan mass without necrosis and hemorrhage in the superior pole. It is 0.1 cm from the renal peivis. The mass is confined in the renal capsule and does not invade the perinephric fat. However, there is possible extension of the mass into the calyces. The uninvolved renal parenchyma is tan/brown with a well defined corticomedullary junction, orderly particle striations and medullary raise. The pelvis and calyces appear smooth and gray/white. No adrenal gland is identified. No lymph nodes or stones are identified. Gross photographs are taken. Inking code: Green -- entire specimen.. Section code: A1 -- ureter, renal artery and possible renal vein resection margins, en face; A2 -- mass with nearest perinephric fat margin; A3 -- mass with pelvis and adjacent rena! parenchyma; A4 - additional section of renal pelvis; A5-A7 -- additional sections of tumor; A8 -- additional section of mass with renal pelvis; A9 - uninvoived kidney including renal parenchyma and pelvis. 8/313
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diff --git a/output/text/cc852e51-7ed1-40a0-aa7b-2a3bfb1b7e5e.txt b/output/text/cc852e51-7ed1-40a0-aa7b-2a3bfb1b7e5e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ccc741af6b27c75ede4911709c931f013ab09175
--- /dev/null
+++ b/output/text/cc852e51-7ed1-40a0-aa7b-2a3bfb1b7e5e.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+FINAL DIAGNOSIS TCGA-B04845 PArt 1:  Right KidNey, RaDical Nephrectomy - A.  RENAL CELL CARCINOMA, CONVENTIONAL (CLEAR CELL) TYPE, FUHRMAN'S NUCLEAR GRADE 2 OF 4, 5.5 cm in grEatest DimensiOn. MICROSCOPIC PERINEPHRIC ADIPOSE TISSUE INVOLVEMENT IS PRESENT. C. ALL SURGICAL MARGINS (URETERAL, VASCULAR, RADIAL) ARE NEGATIVE FOR NEOPLASIA. D.  NO ANGIOLYMPHATIC INVASION IS IDENTIFIED. E.  NON-NEOPLASTIC RENAL PARENCHYMA SHOWS NO SIGNIFICANT PATHOLOGIC FEATURES. PATHOLOGIC TNM STAGE: pT3a Nx Mx. PART 2: RIGHT ADRENAL GLAND, COMPLETION OF RADICAL NEPRECTOMY - ADRENAL GLAND WITH NO SIGNIFICANT PATHOLOGIC FINDINGS.
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diff --git a/output/text/cc8f2d68-02f0-4ab8-9883-f65ed203d9af.txt b/output/text/cc8f2d68-02f0-4ab8-9883-f65ed203d9af.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9b202504310ccc86ecdb00f28174e45631fd60d0
--- /dev/null
+++ b/output/text/cc8f2d68-02f0-4ab8-9883-f65ed203d9af.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+SPECIMENS: A. SIGMOID COLON B. PROXIMAL DONUT C. DISTAL DONUT SPECIMEN(S): A. SIGMOID COLON B. PROXIMAL DONUT C. DISTAL DONUT GROSS DESCRIPTION: A. SIGMOID COLON Received fresh for tissue procurement and labeled with the patient's name and "sigmoid colon" is a closed, unoriented segment of colon measuring 13 cm in length with a diameter of 5 cm. There is an area of stricture measuring 1.2 cm, which is 4.5 cm from the nearest surgical margin. This region is inked black. The colon is opened and there is a fungating exophytic polypoid mass with serpentine border measuring 3.9 cm in length with a diameter of 3.0 cm. It appears to invade through the. muscularis propria. It is located 3.5 cm from the nearest surgical margin and approximately 7.5 cm from the distant margin. The mucosa, extending from the mass to its nearest surgical margin, has a granular appearance. Sections of mass and normal appearing mucosa are submitted for tissue procurement. Normal mucosa is submitted for RNA study. Representative sections are submitted as follows:. A1: margin closest to mass A2: margin distal to mass. A3-A4: sections of mass and deep margin A5-A6: granular mucosa A7: normal-appearing mucosa A8-A9: six possible lymph nodes each distal to mass. A10-A11: four possible lymph nodes each in proximity to mass. A12: two bisected lymph nodes adjacent to mass. B. PROXIMAL DONUT Received in formalin and labeled with the patient's name and "proximal donut" is a donut of pink-tan mucosal tissue measuring 3.2 x 2.4 x 0.6 cm. There is a blue suture throughout the specimen. It is bisected and the mucosa is unremarkable. Representative section is submitted in block B1. C. DISTAL DONUT Received in formalin and labeled with the patient's name and "distal donut" is a donut of pink-tan mucosal tissue measuring 2.2 x 1.7 x 0.5 cm. The mucosal surface has pinpoint areas of hemorrhage. There are surgical staple present. Representative section is submitted in block C1. DIAGNOSIS: A. COLON. SIGMOID. SEGMENTAL RESECTION: - INVASIVE ADENOCARCINOMA, MODERATELY AND POORLY DIFFERENTIATED, SEE SYNOPSIS. - 3.9 CM IN GREATEST DIMENSION. - 3.0 X 1.2 CM IN ADDITIONAL DIMENSIONS - INVADING INTO THE SUBSEROSA. - THE PROXIMAL, DISTAL, AND RADIAL MARGINS ARE NEGATIVE FOR TUMOR. - THE TUMOR IS 3.5 CM FROM THE PROXIMAL MARGIN (CLOSEST MARGIN). - SUSPICIOUS FOR ANGIOLYMPHATIC INVASION. - NO PERINEURAL INVASION IDENTIFIED. - ASSOCIATED WITH A TUBULAR ADENOMA. - METASTATIC CARCINOMA TO TWO OF TWENTY FOUR LYMPH NODES (2/24), WITH EXTRANODAL EXTENSION. B. COLON, PROXIMAL MARGIN, SEGMENTAL RESECTION: - NO MALIGNANCY IDENTIFIED. C. COLON, DISTAL MARGIN, SEGMENTAL RESECTION: - NO MALIGNANCY IDENTIFIED.
+
+--- Page 2 ---
+COMMENT: THE RESULTS OF EXPRESSION OF MISMATCH REPAIR PROTEINS WILL BE ISSUED AS AN ADDENDUM. SYNOPTIC REPORT - COLON & RECTUM Specimens Involved Specimens: A: SIGMOID COLON Specimen Type: Sigmoidectomy Tumor Site: Sigmoid colon Tumor Configuration: Exophytic (polypoid). Tumor size:  3.9cm Additional dimensions 3cm x 1.2cm WHO Classification Adenocarcinoma 8140/3 Histologic Grade: G3: Poorly differentiated. Extent of Invasion:. Subserosa Margins: Margin(s) uninvolved by invasive carcinoma (Proximal, Distal, Radial). Distance of invasive carcinoma from closest margin: 3.5cm Venous/Lymphatic Invasion: Absent Perineural Invasion: Absent Additional Pathologic Findings: Adenoma. Extent of Resection:  R0: Complete resection with grossly and microscopically negative margins. Lymph Nodes: Positive 2 / 24 Extranodal extension: Present Implants: Absent Pathological Staging (pTNM):  pT 3 N 1 M X CLINICAL HISTORY:  None provided PRE-OPERATIVE DIAGNOSIS: Colon ca ADDENDUM: ANALYSIS OF MISMATCH REPAIR PROTEIN EXPRESSION SUMMARY OF IMMUNOHISTOCHEMISTRY/SPECIAL STAINS Material: Block A4 Population: Tumor Cells. Stain/Marker:Result:  Comment: MLH1 Positive MSH2 Positive MSH6 Positive PMS2 Negative The interpretation of the above immunohistochemistry stain or stains is guided by published results in the medical literature, provided package information from the manufacturer and by internal review of staining performance and assay validation within the Of the. The use of one or more reagents in the above tests is regulated as an analyte specitic reagent (ASR). These tests were developed and their performance characteristic determined by the at. They have not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary.. INTERPRETATION: No expression of PMS2 identified.
+
+--- Page 3 ---
+Expression of MLH1, MSH2, MSH6, and PMS2 in the tumor was evaluated by immunohistochemistry. Peritumoral lymphocytes and normal glands serve as internal positive controls expressing MLH1,. MSH2, MSH6, and PMS2. Testing for Microsatellite Instability has been ordered. The results will be issued in a separate report.
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diff --git a/output/text/cc94dc60-0c42-4bf2-92ec-c7b9315afa7c.txt b/output/text/cc94dc60-0c42-4bf2-92ec-c7b9315afa7c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c0a668b4bb2e699be8b3e19c96a9508a7a7938bb
--- /dev/null
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+
+--- Page 1 ---
+UUID:D564A7FB-4F0A-4589-AB32-A6CD88547219 TCGA-A7-A56D-01A-PR Redacted LcDo:3 Final Surgical Pathology Report COrci nomc, Infi1traHng Iuct, K1OS 8560|3 Procedure: Site: CBreast, LLg C&3 PATH Diagnosis A.  Left axillary sentinel lymph node, resection: No evidence of metastasis in one lymph node (0/1). C6eF B. Left breast, simple mastectomy:. Infiltrating ductal carcinoma, grade 3, 3.2 cm in greatest dimension. Surgical margins negative but close, less than 2 mm. Left axillary contents, resection: No evidence of metastasis in 7 lymph nodes (0/7) 11/2q/12 Microscopic Description: Microscopic examination performed.. A. Sections of the sentinel lymph node demonstrate no evidence of. metastatic disease.  The node is examined by multiple sectioning with hematoxylin and eosin and by immunohistochemistry for pankeratin.. B. Invasive Carcinoma: present Histologic type: Infiltrating ductal carcinoma Histologic grade: Overall grade: 3 Architectural score: Nuclear score: Mitotic score: Greatest dimension (pT): 3.2 cm,. pT2 Specimen margins: Negative but close, less than 2 mm over a. distance of 5 mm Vessel invasion: Not identified Calcification: Not identified Ductal carcinoma in situ: Not identified Description of non-tumorous breast: Proliferative fibrocystic. changes with intraductal papillomatosis Comments: None Prognostic markers: Previously performed C Sections of the left axillary contents demonstrate no evidence of. metastasis in 7 lymph nodes. Specimen A.  Left sentinel node-axillary. B. Left breast-tumor at 7 o'clock C. Axillary contents Clinical Information Carcinoma left breast, core biopsy positive here Intraoperative Consultation AFs left axillary sentinel lymph node, excision: No evidence of metastasis in one lymph node
+
+--- Page 2 ---
+Gross Description A. Container a is labeled with the patient's name, medical record. number and "sentinel lymph node". The specimen consists of a single piece of fatty tissue which when bisected holds a single lymph node measuring 1.0 x 0.0 0.5 cm. Bisected and submitted in block AFs. B. Received fresh labeled "left breast" is a 25.5 cm (medial to lateral) by 17.0 cm (superior to inferior) by 4.5 cm (anterior to posterior) soft, lobulated tan-white-gold portion of fibroadipose tissue oriented per placement of designated tumor as stated previously. A 19.3 x 8.5 cm wrinkled tan skin ellipse with an eccentric, 1.0 x 1.0 x 0.5 cm nipple is present along the anterior aspect..  A palpable mass is evident at 7 o'clock, corresponding to the lower inner quadrant. The antero- -inferior surface of the specimen in the vicinity of the mass is inked blue.  The intact deep margin is inked black and the specimen. is sectioned. There is a well-circumscribed, 3.2 cm (medial to lateral) by 2.4 cm (anterior to posterior) by 2.0 cm (superior to inferior) rubbery tan-white tumor mass within the lower outer quadrant. On sectioning the tumor appears to extend to within 0.2 cm of the inked anteroinferior surface and 1.5 cm of the inked deep margin. portion of tumor and a portion of normal parenchyma are submitted for tissue procurement as requested.  The cut surfaces throughout the. remainder of the specimen consist predominantly of soft, lobulated tan gold adipose tissue with a minimal amount of interspersed dense tan-white fibrous tissue. No additional mass lesion or abnormality is identified. Summary: 1 - tumor to inked deep margin, 2 through 4 - tumor to inked anteroinferior margin, 5 and 6 - tumor to adjacent parenchyma, 7 . random upper outer quadrant, 8 - upper inner quadrant, 9 - lower inner quadrant,  10 - lower outer quadrant, 11 - junction of the 4 quadrants, 12 - nipple Received fresh labeled "Axillary contents" is a 9.3 x 7.8 x 1.7 cm C. portion of soft, lobulated tan gold adipose tissue. A few slightly rubbery pale tan to tan pink tissues in keeping with lymph nodes measuring up to 3.4 cm in greatest dimension are recovered. The lymphoid tissues are entirely submitted.. RS 4 Summary: 1 - 2 lymph nodes, 2  - 1 bisected lymph node, 3 and 4 -. bisected largest lymph node
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diff --git a/output/text/ccb9940a-e505-479a-bd87-271584cdfef4.txt b/output/text/ccb9940a-e505-479a-bd87-271584cdfef4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..45c7aa9233970bba8aada977b0ec6bc1d9d2b0f5
--- /dev/null
+++ b/output/text/ccb9940a-e505-479a-bd87-271584cdfef4.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+IcD6 3 'areeron, uryiltiatirg dust 85/3 TSS Surg Date ! SPECIMENS: A. RIGHT AXILLARY CONTENTS 1J8|10[14 B. RIGHT BREAST WIDE EXCISION C. RIGHT POSTERIOR MARGIN SPECIMEN(S): UUID: E28607CD-0847-46F4-8E69-2D1DC80DE56F TCGA-E2-A9RU-01A-PR" A. RIGHT AXILLARY CONTENTS Redacted B. RIGHT BREAST WIDE EXCISION C. RIGHT POSTERIOR MARGIN INTRAOPERATIVE CONSULTATION DIAGNOSIS: A.-excision right breast: Mass/lesinn identified 1 cm to the superior margin. Diagnosis called by Dr. to Dr. at DIAGNOSIS: A.RIGHT AXILLARY CONTENTS: -12 OF 22 LYMPH NODES ARE POSITIVE FOR METASTATIC CARCINOMA (12/22) -FOCAL EXTRANODAL INVOLVEMENT IS IDENTIFIED. B. RIGHT BREAST WIDE EXCISION: -INVASIVE DUCTAL CARCINOMA (IDC). SBR GRADE 3. MEASURING 3.5 CM - DUCTAL CARCINOMA IN -SITU, INTERMEDIATE NUCLEAR GRADE, SOLID AND CRIBRIFORM TYPES (MINOR COMPONENT).  SURGICAL RESECTION MARGINS ARE NEGATIVE FOR TUMOR - BIOPSY SITE CHANGES WITH FIBROSIS, GRANULATION TISSUE, FOREIGN BODY GIANT CELL REACTION AND FAT NECROSIS - SEE SYNOPTIC REPORT AND SEE NOTE. C. RIGHT POSTERIOR MARGIN: - MAINLY ADIPOSE TISSUE WITH CALCIFICATION OF VESSEL WALL (MONCKEBERGS CALCIFIC SCLEROSIS). - NO TUMOR IS IDENTIFIED. SYNOPTIC REPORT - BREAST Specimens Involvede Specimens: A: RIGHT AXILLARY CONTENTS B: RIGHT BREAST WIDE EXCISION Specimen Type: Excision Localization: Needle Laterality: Right Multifocality: No WHO CLASSIFICATION Invasive carcinoma of no special type (NST) 8500/3 Tumor size: 35mm Additional dimensions: 30mm x 30mm Tumor Site:  Not specified Margins: Negative  distance from (in mm):anterior margin: 6 Tubular Score: 3 Nuclear Grade: 3 Mitotic Score: 3 Modified Scarff Bloom Richardson Grade: 3 Necrosis: Present Vascular/Lymphatic Invasion: Present Lymph nodes:  Non-sentinel lymph node Lymph node status:  Positive 12 / 22 Size of largest metastasis: 20mm
+
+--- Page 2 ---
+TSS Surg Date Yes Micrometasteses: Extranodal extension: Yes. DCIS PRESENT Yes Margins: Margins uninvolved by DCIS Specify: 1.5 mm to superior resection margin DCIS Quantity: Estimate % 2 DCIS Type: Solid Cribriform DCIS Location: Separate from invasive tumor mass Nuclear Grade: Intermediate Necrosis: Absent ER/PR/HER2 Results Estrogen Receptor: Positive Allred Score: 6 Progesterone Receptor: Negative Allred Score: 0 Her2: Interpretation: Negative Methodology: FISH Performed on Case: (outside slideso Pathological staging (pTN): pT 2 N 3a Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition. GROSS DESCRIPTION: A. RIGHT AXILLARY CONTENTS Received fresh labeled with the patient's identification and "right axillary contents " are piece of yellow- tan adipose tissue, 14 x 10 x 2 cm, containing lymph nodes ranging from 0.2 cm to 2 cm; lymph nodes are sectioned and submitted entirely: A1: 6 possible lymph nodes. A2: 2 lymph nodes, bisected (one inked green). A3-A5: 1 lymph node, bisected, each block. A6: 1 lymph node A7: 2 lymph nodes, bisected (one inked green). A8: 1 lymph node, bisected A9:2 lymph nodes A10: 1 lymph node A11: 3 lymph nodes A12-13:1 lymph node A14-A17: 1 lymph node A18-A19: 1 lymph node B. RIGHT BREAST EXCISION  Received fresh labeled with the patient's identification and "right breast excision" is an previously inked 177 g, 11.5 cm medial to lateral x 7.5 cm superior to inferior x 3.5 cm anterior to posterior, excision. The overlying skin measuring 9.5x 7 cm in diameter. There are multiple brown papules on the skin. Ink code: anterior-yellow, posterior-black, medial-green, lateral-red, superior-blue, inferior-orange. The. specimen is serially sectioned from medial to lateral into 7 slices revealing a 3.5 x 3 x 3 cm, white, firm mass that is closest to the superior and anterior margins at 1 cm. The clip was retrieved in slice 4 Representatively submitted as per the attached diagram:. B1: medial margin B2: slice 2, anterior margin with tumor B3: slice 2, superior margin with tumor B4: slice 3, skin with tumor B5-B6: slice 3, anterior margin with tumor B7: slice 3, superior margin with tumor B8: slice 3, posterior margin with tumor B9: slice 3, inferior margin
+
+--- Page 3 ---
+tSs Surg Date B10: slice 4, tumor around clip B11: slice 4, skin with tumor B12: Slice 5, superior and anterior margins. B13: slice 7, lateral margin. C. RIGHT POSTERIOR MARGIN  Received fresh labeled with the patient's identification and "right posterior margin" is a yellow-tan adipose tissue, 10 x 2 x 1.3 cm. One surface has been marked with clips indicating new margin. This. surface is inked black. Serial sectioning does not reveal any abnormality. Representative sections submitted in 4 cassettes CLINICAL HISTORY: None Given PRE-OPERATIVE DIAGNOSIS: None Given Gross Dictation: Final Review: Final: M.D., M 1/7/14
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diff --git a/output/text/cce01005-aff8-4d50-9eca-263eaf263b3d.txt b/output/text/cce01005-aff8-4d50-9eca-263eaf263b3d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1db3ffbeeabc2ee96ad800b392941a8b7aac0b8c
--- /dev/null
+++ b/output/text/cce01005-aff8-4d50-9eca-263eaf263b3d.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+SURGICAL PATHOLOGY Surgical Pathology Report Diagnosis: A: Omentum, mass, excision  - Metastatic adenocarcinoma, consistent with colonic primary B: Terminal ileum, appendix and right colon, right hemicolectomy Tumor Histologic Type: Invasive moderately differentiated colorectal adenocarcinoma Histologic Grade: 2 Tumor Location: Right colon Depth of Invasion: Through muscularis propria into the subserosa, pericolic soft tissue Lymphovascular Invasion: Not identified Perineural Invasion: Not identified Margins: Proximal margin: Negative Distal margin: Negative Circumferential (radial) margin: Negative but close, <1.0 mm Distance of carcinoma from closest margin (specify): <1.0 mm from serosal surface; 8.5 cm from proximal mucosal margin.. Regional Lymph Nodes: Total number with metastasis: 1 Total number examined: 24 Additional pathologic findings: Appendix with follicular lymphoid hyperplasia and no tumor seen; tumor satellite nodule identified.. AJCC PATHOLOGIC TNM STAGE: pT3 pN1a Note: This pathologic stage assessment is based on information available at the time of this report, and is subject to change pending clinical. review and additional information. C: Liver mass, Segment 5, removal - No evidence of metastatic disease. - Benign liver with minimal steatosis and mild portal triaditis D: Hernia sac, removal - Benign fibrovascular and fibroadipose soft tissue, consistent with hernia sac, with focal foreign body giant cell reaction with associated polarizable foreign material; no evidence of metastatic disease. Clinical History: large mass in the ascending colon. Biopsy demonstrates invasive moderately differentiated adenocarcinoma. CT imaging confirms mass and evidence of metastatic disease. Gross Description: Received are four formalin-filled containers. Container A: SITE: "omentum" METHOD: excision MEASURE: 6.5 x 3.6 x 1.5 cm COMMENT: yellow/tan fibroadipose tissue with a central firm hard mass; cut section demonstrates a white/yellow firm surface. BLOCK: A1, omental mass Container B:
+
+--- Page 2 ---
+Specimen fixation: formalin Parts of bowel received: terminal ileum, cecum and proximal ascending colon. Specimen length: 27.3 cm Orientation: The specimen was received with a stitched end which appears to be the right ascending colon, inked blue. The distal ileum is inked black. Tumor location: tumor is located just distal, but apparently involving the ileocecal valve Gross appearance of tumor: distal to the ileocecal valve is a ulcerated mass with whorled edges, this mass is firm; proximal to this is the ileocecal valve and this also appears to be at least superficially studded with tumor Tumor dimensions: 3.5 x 2.4 x 1.2 cm Circumferential growth: 70% Gross depth of invasion: the mass appears to grossly invade the subserosal soft tissues Gross evidence of perforation through visceral peritoneum: no. Luminal obstruction: no Bowel circumference at tumor site: 6.0 cm. 1.5 cm diameter at tumor site Gross distance of tumor from margins: 9 cm from blue inked distal margin, 8.5 cm from black inked proximal margin Lymph nodes: per block summary Other remarkable findings: The rest of the colon and ileum are grossly unremarkable. Appendix is present with the specimen and is not grossly involved. Tissue submitted for special investigation: tissue submitted to Tissue Procurement Digital photograph taken: no Block Summary: (Inking: proximal ileal margin=black, distal right colonic margin with stitch=blue) B1 - appendix, longitudinal section of tip, cross section of base B2 - proximal (black inked) margin, en face  B3,B4 - distal (blue inked) margin, en face B5 - section of mass. B6,B7 - additional section of mass, bisected B8 - mass in relation to pericolic fat B9 - section of ileocecal valve B10 - additional section of ileocecal valve B11 - five lymph node candidates B12 - five lymph node candidates B13 - five lymph node candidates B14,B15 - one grossly positive node, bisected B16 - four lymph node candidates B17 - two lymph node candidates Container C: SITE: "liver, Segment 5" METHOD: biopsy MEASURE: 1.0 x 0.8 x 0.4 cm COMMENT: tan/brown soft tissue mass BLOCK: C1, Container D is additionally labeled "hernia sac." It holds three pink/tan soft tissue fragments measuring 2.5 x 1.9 x 0.8 cm in aggregate
+
+--- Page 3 ---
+Block Summary: D1 - hernia sac Fibroadipose tissue remains. Grossing Pathologist: Light Microscopy: Light microscopic examination is performed by
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diff --git a/output/text/cce7d5bd-1817-47a4-a603-3d22977b997f.txt b/output/text/cce7d5bd-1817-47a4-a603-3d22977b997f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2e7409cbad13d651d617dc0038c101387d9c8905
--- /dev/null
+++ b/output/text/cce7d5bd-1817-47a4-a603-3d22977b997f.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:DA17 -1799-4A7F-8D98-34D2CD639E07 TCGA-P-A5Z9-01A-PR Redacted Pathology #: Patient: Med. Record. No.: Age: Date of Procedure: Sex: Date of Birth: F Date Received: Submitted by: Report also to: Pathology Report ICD-o-3 Acnomo, p0ayoiSlauy nenal e0J U 8260|3 DIAGNOSIS: h4|q91L3 SPECIMEN Left partial nephrectomy TUMOR Histologic type:  Papillary renal cell carcinoma Histologic grade (Fuhrman nuclear grade): Grade 3 Focality:  Solitary within specimen Tumor size (greatest dimension):. 6cm Extent of direct tumor invasion:.  No direct extension beyond kidney. Sarcomatoid component: Absent Lymphovascular invasion (exc!uding renal vein): Absent Renal vein involvement: Indeterminate (cannot be assessed) Pathologic findings in non-neoplastic kidney: No additional significant pathologic findings Adrenal: Not present MARGINS All margins negative for carcinoma LYMPH NODES Cannot be assessed STAGING (AJCC) Primary Tumor: pT1b Lymph Nodes: pNX Distant Metastasis: Not applicable CLINICAL INFORMATION: Left kidney mass; research specimen SPECIMEN(S) RECEIVED Left kidney mass Pathology Report Page 1 of 2
+
+--- Page 2 ---
+Patient: MRN: GROSS DESCRIPTION: Received fresh is a 75-gram, 6.5 x 6.3 x 5.8 cm soft, nodular, red-gray partial nephrectomy covered with a few tags of golden yellow perinephric fat. The irregular, partially cauterized 5 x 4.5 cm resectional margin is inked. Sectioning reveals a soft, nodular, friable, dusky, mottled yellow-gray to red-gray 6 x 5.7 x 4.9 cm mass which. appears grossly to come within 0.1 cm of the inked margin of resection. The nodular mass does not grossly appear to invade through the renal capsule. There is a narrow rim of rubbery, red-gray renal parenchyma present at the base of the specimen. Representative sections to include the inked margin are submitted in A1-A2. Additional sections to include the periphery are submitted in A3. Slides were microscopically examined by the pathologist. Evaluation performed by Electronically signed Pathology Report Page 2 of 2
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diff --git a/output/text/cd0f0570-732a-412b-b63b-5503758b8f6a.txt b/output/text/cd0f0570-732a-412b-b63b-5503758b8f6a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5948d73c0c535fdda10934a4867a73615359ec2e
--- /dev/null
+++ b/output/text/cd0f0570-732a-412b-b63b-5503758b8f6a.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+IcD o -3 0 850@3 C6C F R%rastNsS c 5s.9 UUID:C26EAF0E-202B-4F3E-9E59-3395A1BFCAB8 TCGA-A7-A6VV-01A-PR Redacted pa tK R %uast mdleni c5s.8 QtJ z/25/13 Final Surgical Pathology Report Procedure: Diagnosis A. Sentinel lymph node, right axilla, biopsy: One negative lymph node (0/1). B. Breast, right, mastectomy: Invasive ductal carcinoma, grade 3, size 4.5 cm in greatest dimension, with ductal carcinoma in-situ, grade 3 with necrosis; negative margins of excision. C. Breast, left, mastectomy: Focal atypical ductal hyperplasia; negative margins of excision. D. Lymph nodes,  right axilla, regional resection:  Four negative lymph nodes (0/4). Microscopic Description: Invasive carcinoma: Histologic type: Ductal Histologic grade: Overall grade: 9/9 Architectural score: Nuclear score: 3 Mitotic score: Greatest dimension (pT): Size 4.5 cm in greatest dimension Specimen margins:  Negative Vessel invasion: Not identified Nipple (Paget's): Negative Invasion of skin or chest wall:  Negative Ductal carcinoma in situ: Histologic pattern:  Solid, cribriform Nuclear grade: 3 Central necrosis: Present % Dcis of total tumor (if mixed): 10% Extensive intraductal component (present/absent): Absent Specimen margins: Negative Calcification: Present Description of non-tumorous breast: Fibrocystic changes including apocrine metaplasia with cyst formation Comments: Prior biopsy site identified. Focal atypical ductal hyperplasia, with partial involvement of a duct by a cribriform cell population, is present within the left breast. Distant metastasis (pm): Unknown Lymph nodes: Number of positive nodes of total: 0 of 5 Size of largest metastasis: N/A Extracapsular extension (present/absent): N/A pN: pNO Prognostic markers: See previous core biopsy at Specimen A. Right sentinel node (axillary) B. Right breast tumor at 12:00 C. Left breast tissue D. Right axillary content
+
+--- Page 2 ---
+Clinical Information Right breast, tumor at 12:00, large mass + for carcinoma right breast Intraoperative Consultation Ane negative lymph node. Gross Description A. Received unfixed for frozen section, labeled sentinel node right, is a lymph node that is fat-replaced and 2 x 1.5 x 1.5 cm, entirely frozen in 3 blocks. B. Received untixed for tissue procurement, labeled right breast, is a. 1444 gram right breast that is unoriented and 23 cm medial to lateral, 22 cm superior to inferior, and 4.5 cm anterior to posterior. There is an anterior black skin ellipse, 20 x 5 cm with 5 cm areola and 1.5 cm nipple. There is a tan-gritty tumor at 12:00, up to 4.5 cm in greatest dimension, and close to the anterior margin.. Sections as follows: 1-6 continuous tumor, 7/8 tumor, 9 tumor, 10 RUQ random, 11 RLQ random, 12 LLQ random, 13 LUQ random, 14 nipple, 15 areola. C. Received unfixed, labeled left breast, is a postion of fibroadipose breast tissue and skin that is 818 grams and 26 x 17 x 5 cm. Skin is. darkly pigmented, and without focal lesions. Sectioning through the breast tissue shows no mass lesions. Representative sections in 8 blocks. D. Received unfixed, labeled right axillary content, is a 9 x 7 x 2 cm portion of fatty nodal tissue..  Lymph nodes are identified: 1 one. node, 2 two nodes, 3 one node. Electronically Signed By:
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diff --git a/output/text/cd1c930b-cff0-4d1d-be1a-fb95c306a9c1.txt b/output/text/cd1c930b-cff0-4d1d-be1a-fb95c306a9c1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4c33deeafc07d0af0b910742c272d9721713f8af
--- /dev/null
+++ b/output/text/cd1c930b-cff0-4d1d-be1a-fb95c306a9c1.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TCGA #: Sample ID #: Diagnosis: This is an invasive, moderately differentiated adenocarcinoma in the sigmoid colon Both resection margins are tumor-free, as is the area of the central vascular ligature. There is also a lymph node metastasis. Tumor classification: ICDO-DA M 8140/3 G 2 p T 3, p N 1 (1/19), R0. 1cD-0-3 Adenrcsiuinomn, N05 8140|3 Site: Siganid co/m C18.7 pw 3|3o/i UUID:SA447FA7-E561-4F17-9A66-0CF944B208C3 CGA-AA-A01S-01A-PR Redacted
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diff --git a/output/text/cd74fc0c-e885-47be-a1d4-c64deacfc796.txt b/output/text/cd74fc0c-e885-47be-a1d4-c64deacfc796.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5ca1ee245580dd38eaca36ca65ccadb5360f8e76
--- /dev/null
+++ b/output/text/cd74fc0c-e885-47be-a1d4-c64deacfc796.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis This concerns an invasive, poorly differentiated colic adenocarcinoma with partial. neuroendocrine differentiation (G3), with penetration of all wall layers (pT3), with vascular. invasion (L1, V1), with five lymph node metastases (5 of 15) and free resection margins as well as chronic appendicitis and free ligature area..
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diff --git a/output/text/cdcd80f2-2835-4617-8a3c-aecadf55eca5.txt b/output/text/cdcd80f2-2835-4617-8a3c-aecadf55eca5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0ee59f2decae90c80d9a9fe25ee5a8ae802782e2
--- /dev/null
+++ b/output/text/cdcd80f2-2835-4617-8a3c-aecadf55eca5.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:F323F54C-A86A-47DB-A26D-7541C854A08E CGA-DM-A0X9-01A-PR Redacted TSS Patient ID: Sample Procurement: Date: Gender: Date of Birth Vital Status: Date of Death: Race: White Ethnicity: Not Hispanic or Latino  Specific Ethnicity: Histologic Subtype: Colon adenocarcinoma Date of Initial Path Dx:. Primary Site: Colons Anatomic Site: Ascending Colon T Stage: 3 N Stage: 0 M Stage: 0 Overall Stage: IIA Date of Normal Procurement: 1cD-0 -3 Qdnocaicnoma, N0s 814013 Sih:Qsundiig co1on C18.3 1/1
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diff --git a/output/text/cdf186c8-1d83-4d0c-9a56-58a8868ce72f.txt b/output/text/cdf186c8-1d83-4d0c-9a56-58a8868ce72f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..97ade164c22b436ede2e38825315da0cbbf37eba
--- /dev/null
+++ b/output/text/cdf186c8-1d83-4d0c-9a56-58a8868ce72f.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Ic.0-3 Cascnoma, mfi1tratrg oluctrl crd lotul 8523 Sif: bussf, Nos c50.9 Mw 4/|1 Procurement Date: . Laterality:Right, upper outer quadrant Path RepOrt:BREAST TISSUE CHECKLIST Specimen type: Radical mastectomy Specimen size: Not specified Tumor site: Breast Tumor size: 1.8 x 1.6 x 1.6 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal and lobular carcinoma Histologic grade: Tumor extent: Not specified Lymph nodes: 0/4 positive for metastasis (Regional 0/4) Extracapsular invasion of the lymph nodes: Not specified Margins: Not specified Nottingham Histologic Score Tubule formation: Not specified UUID:FC896EB8-1CEC-46A0-82E1-E3F3FAA869F1 TCGA-E9-A22B-01A-PR Redacted Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None
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diff --git a/output/text/cdf51225-ce13-475f-ba10-1468be8122fb.txt b/output/text/cdf51225-ce13-475f-ba10-1468be8122fb.txt
new file mode 100644
index 0000000000000000000000000000000000000000..13ccc5c41dabf3d1147933c5431aafea5cae0144
--- /dev/null
+++ b/output/text/cdf51225-ce13-475f-ba10-1468be8122fb.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+IaD o-3 Redacted Cuuimt, Adveual Cortica1 837013 S,te: Adrenai 6laud Corter Q74.D Jwq1/13 Procedure: adrenalectomy, splenectomy Gross description: 8 x 7 x 8cm, 365g Diagnosis: adrenocortical carcinoma, with bonbe metastasis Reference Pathology: none 4f1f7-Nw pafHnfo ned`wtL mt+r#c nvowent whH- Weiss=4 . Maligaut. cisu Peso wrt'll NiyusA mlin
+
+--- Page 2 ---
+Patient # from Tissue Source Site Date of report. Date of Surgery/specimen collection Site (confirmed to be adrenal) with laterality indicated. Left Number of lesions (?) Two, primary tumor & bony metastasis, tumor obtained from primary site Tumor size(s) 8x7x8cm Histologic diagnosis ACC Lymph Node Status x Pathologic information T4NxM1 Weiss score 4, derived from path report
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diff --git a/output/text/cdf535bd-aff6-4bdf-a82f-24f714d39da6.txt b/output/text/cdf535bd-aff6-4bdf-a82f-24f714d39da6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..55556dd92a7580f8940c3cd173ace3dbaa54b6b0
--- /dev/null
+++ b/output/text/cdf535bd-aff6-4bdf-a82f-24f714d39da6.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+1cs-0 - 3 Page 1 of 3 Stq: brast NOs c50.9 Patien Surgical Pathology: Additional Infc Surg Path UUID:40EE8416-9DD8-457D-94AC-A871B5C628730 TCGA-B6-A1KF-01A-PR Redacted CLINICAL HISTORY:S Right breast carcinoma.. GROSS EXAMINATION: A. "Right)breast tissue (AFl)", received fresh. An oriented breast excision with sutures as follows: Long - lateral, short - superior, (Dr. A 4.3 x 0.8 cm ellipse of tan skin with a 6.8 x 5.2 x 3.4 cm of underlying fibrofatty breast tissue is inked as follows: Superior - blue, inferior black, posterior - green. The specimen is sectioned from lateral to medial to reveal a circumscribed firm yellow sabulous 2.4 x 1.5 x approximately 1.5 cm mass. The mass is within 0.i cm of the green inked posterior margin and within 0.2 cm of the blue inked superior margin. The lesion's edge is approximately 0.4 cm from the black inked inferior margin, 2.5 cm subjacent to the skin surface and approximately 0.6 cm from the lateral margin. The adjacent parenchyma is  composed of lobules of yellow-pink adipose intermixed with focally dense white-pink fibroconnective tissue with no additional lesions noted..  Representative sections from the mass is frozen as AFl.  The remnant is submitted as Al.. Block Summary: A1 Frozen section remnant. A2-14 Representative sections from lateral towards medial respectively.  The sections include the entire lesion in relationship to the closest margins as well as the lateral margin (A2) and the medial margin Al4. A15-25 Remaining breast, submitted in toto. See photograph on file in pathology department for location of blocks. B. "Right breast tissue new posterior margin suture in new margin", received fresh. A 3.9 x 2.7 x 0.8 cm portion of fibrofatty tissue with a suture on one surface. The suture surface is marked blue, the specimen is transversely sectioned and entirely submitted as Bl-b4. C. "Right breast tissue new superior margin suture on new margin", received fresh. A 4.1 x 2.7 x 1.2 cm portion of yellow-white fibrofatty tissue with a suture present on one surface. The suture surface is marked blue, the specimen is transversely sectioned and submitted as C1-c4. D. "Right axillary node, suture on apex". received fresh. An 11.2 x 7.5 x 1.2 cm portion of fibrofatty tissue with a suture present at the apex. The specimen is dissected for lymph node candidates. Block Summary: D1 - 1 Lymph candidate proximal. D2 - 3 lymph node candidates, medial.. D3- 6 Lymph nodes, medial. D4-5 Bisected lymph node candidate. D6 2 lymph node candidates, distal. D7 - 2 lymph node candidates, distal.. 37 /Dr. INTRA OPERATIVE CONSULTATION: A. "Right breast tissue" AFl- invasive carcinoma present. (Dr. DIAGNOSIS : A. "RIGHT BREAST TISSUE" (EXCISIONAL BIOPSY): INFILTRATING CARCINOMA PRESENT, HISTOLOGIC TYPE DUCTAL. https:
+
+--- Page 2 ---
+Page 2 of 3 N.S.A.B.P. NUCLEAR GRADE: 3 OF 3. N.S.A.B.P. HISTOLOGIC GRADE: 3 OF 3. GROSS TUMOR SIZE: 2.4 X 2.4 X 1.5 CM. SIZE OF INVASIVE COMPONENT: 2.4 XMX 1.5 CM. LYMPHATIC/VASCULAR INVASION: ABSENT. MULTIFOCAL TUMOR: ABSENT. IN-SITU CARCINOMA: PRESENT, OCCUPYING LESS THAN 5% OF TUMOR (SEE COMMENT). TYPE OF IN-SITU CARCINOMA: COMEDO AND CRIBRIFORM. SIZE OF IN-SITU CARCINOMA: APPROXIMATELY 4.8 CM, SEE COMMENT. EXTENSIVE INTRADUCTAL COMPONENT: ABSENT. STATUS OF NON-NEOPLASTIC BREAST TISSUE: BENIGN FIBROCYSTIC CHANGES.S SIZE OF BIOPSY: 6.8 X 5.2 X 3.4 CM. MICROCALCIFICATIONS ABSENT.S SURGICAL MARGIN STATUS: NEGATIVE (CLOSEST MARGIN 3 MM TO DCIS). ESTROGEN/PROGESTERONE RECEPTOR AND CELL CYCLE ANALYSIS: PENDING. METHODOLOGY: IMMUNOHISTOCHEMISTRY, PARAFFIN BLOCK A6. RESULTS WILL BE ISSUED IN AN ADDENDUM. coMMenr: Although there is very little in-situ carcinoma within the invasive tumor mass, there is a large area of Dcis adjacent to the tumor, extending in a medial direction to near the medial margin.  Based on the number of slides involved, the Dcis involves an area of approximately 4.8 cm in largest. dimension. B. "RIGHT BREAST TISSUE, NEW POSTERIOR MARGIN" (RE-EXCISION) : BREAST TISSUE, NO EVIDENCE OF MALIGNANCY. "RIGHT BREAST TISSUE, NEW SUPERIOR MARGIN" (RE-EXCISION) : BREAST TISSUE, NO EVIDENCE OF MALIGNANCY. D. "RIGHT AXILLARY LYMPH NODES" (DISSECTION) : METASTATIC ADENOCARCINOMA IN TWO OF FOURTEEN AXILLARY LYMPH NODES (2/14). SIZE OF LARGEST METASTASIS: 1.O CM. EXTRACAPSULAR EXTENSION: ABSENT. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es). M.D. Page # Electronically signed: ADDENDUM 1: Tissue was sent to the. for assay of the estrogen. and progesterone receptors. The estrogen receptor activity was judged to be negative with an estimated FMoL value of 0. The progesterone receptor activity was judged as negative with an estimated Fmol of value of 0. Please refer to for a complete report.. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es). M.D. Page # https://
+
+--- Page 3 ---
+Page 3 of 3 Electronically signed: ADDENDUM 2: This addendum is issued to report the results of an additional study. The previous diagnoses are unchanged. An immunostain for HEr2/neu shows moderate (2+) membrane staining in approximately 50-75% of the tumor cells and is. interpreted as posiTivE for HER2/neu overexpression. METHODOLOGY: Immunostaining for HEr2/neu (c-erbB-2) oncoprotein is performed on recut. sections of Block A6. The imnunostaining is done using DAko rabbit anti-human. c-erbb-? oncoprotein which is an affinity-isolated antibody. product number . The immunostaining is performed after antigen retrieval by. heating the unstained sections at 95 degrees centigrade for 20 minutes in 10. hour at 37 degrees centigrade. The Histostain Plus kit is used as the detection system. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es).. M.D. Page # Electronically signed: https:
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diff --git a/output/text/ce056aed-7669-4884-880b-895c9d15ce69.txt b/output/text/ce056aed-7669-4884-880b-895c9d15ce69.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d42a5accc8be67f82d8a9c9ffd01c6103d530537
--- /dev/null
+++ b/output/text/ce056aed-7669-4884-880b-895c9d15ce69.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+*** Diagnosis/Diagnoses: *** 1. Sections of a polypoid neoplasm of the colonic mucosa with the structure of a tubular adenoma with high-grade dysplasia or transition to at least intramucosal adenocarcinoma in situ (synonym according to WHO: high-grade intra-epithelial neoplasia, according to IUCC: pTis) 2.: Small, or only small portions of, tubular adenomas of the colonic mucosa with slight dysplasia (synonym: low-grade intra-epithelial neoplasia). 3.: Tubular adenoma of the colonic mucosa with high-grade dysplasia and transition to an intramucosal adenocarcinoma (synonym according to WHO: high-grade intra-epithelial neoplasia, according to IUCC: pTis) In 1. and 3., no detectable transition to a manifest, deeper colon carcinoma infiltrating the wall layers. Complete tumor resection -- where not already done - is recommended Diagnosis/Diagnoses Right hemicolectomy specimen with an ulcerated colon carcinoma in the area of the cecal pole measuring 4 cm in the largest diameter and displacing the appendiceal orifice, arising from a tubulovillous adenoma with severe epithelial dysplasia (synonym: high-grade intra-epithelial neoplasia). Invasive tumor spread as far as the muscularis propria. Appendix with formation of an obstructive type of mucocele and with persistent or florid chronic appendicitis and. perityphlitis. Oral and aboral resection margin and greater omentum tumor-free.. Twenty-four mesocolic and mesenteric lymph nodes tumor-free and with uncharacteristically reactive changes. Tumor stage therefore pT2 pN0 (0/24) L0 V0; G2
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diff --git a/output/text/ce1a9107-39b5-4a17-9a14-acf623700dad.txt b/output/text/ce1a9107-39b5-4a17-9a14-acf623700dad.txt
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index 0000000000000000000000000000000000000000..16deb3a3c3db8fc6da096ae9aacbb75d42a41c9e
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+TCGA-BO-4838 FINAL DIAGNOSIS: Kidney, Right, LAparoscopic nephrectomy:  RENAL CELL CARCINOMA, CONVENTIONAL (CLEAR) CELL. TYPE. FUHRMAN' S nUCLEAR GRADE IS 3 OF 4. C.  THE GREATEST DIAMETER OF THE NEOPLASM IS 4.2 CM. D. THE NEOPLASM IS CONFINED WITHIN THE RENAL CAPSULE. :. NO INVASION OF THE RENAL VEIN IS IDENTIFIED. ALl SURGICAl MARGINS ARE fREE OF THe NEOPLASM. G.  THE NON-NEOPLASTIC KIDNEY REVEALS FOCAL GLOMERULOSCLEROSIS H. THE ADRENAL GLAND IS NOT SUBMITTED. TNm STAGE: pT1b NX mX. J. TNM HISTOLOGIC GRADE = G3.
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diff --git a/output/text/ce21a76a-a97c-4ba5-9faa-2d60a6070f80.txt b/output/text/ce21a76a-a97c-4ba5-9faa-2d60a6070f80.txt
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index 0000000000000000000000000000000000000000..d48190218a818bd1660a6469ba6eb64217973a0b
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+/cs-0-3 Carcinomn, mfiItnshmy ductl N0s 85o0/3 Psn Sh: Buast U0$ c5o.4 /19/ Sitv:Erost Nss c5o.9 C4cF Diagnosis: 1. Multifocal poorly differentiated invasive ductal breast carcinoma, G Ill, with small intraductal components. Largest tumor focus 2.6 cm. A second of a total of three additional tumor foci, in some cases only microscopically visible, located in the vicinity of the skeletal muscle that was also resected. Summary tumor classification: multifocal invasive ductal breast carcinoma with a small intraductal component, NOS, G Iil, pT2(m)pN2a(5/15)L0V0R0. UUID:5DA3A8E1-7EE6-45EC-89EC-69423E2B8668 Redacted TCGA-A8-A07I-01A-PR
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diff --git a/output/text/ce331623-e273-4f13-a24f-169585da1500.txt b/output/text/ce331623-e273-4f13-a24f-169585da1500.txt
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index 0000000000000000000000000000000000000000..738081990f619eed58a448516c0ea636ace439ab
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+Page 1 of 6 UUID: B680364D-6FEC-45A5-95FC-1055E37DFCE2 TCGA-XF-AAN7-01A-PR Redacted DIAGNOSIS: RADICAL CYSTECTOMY WITH STUDOR POUCH TO URETHRA: D63 RIGHT DISTAL URETER (A) : Carcuene,urstteseal No5 812o|3 INTRAOPERATIVE.FROZEN SECTION DIAGNOSIS: BENIGN Sute. NBladlder NbS Cb7.9 FINAL DIAGNOSIS: BENIGN URETER NO DYSPLASIA OR CARCINOMA IDENTIFIED AO 3/zi|i4 LEFT DISTAL URETER (B): INTRAOPERATIVE FROZEN SECTION DIAGNOSIS: BENIGN FINAL DIAGNOSIS: BENIGN URETER NO DYSPLASIA OR CARCINOMA IDENTIFIED APICAL URETHRAL MARGIN F/S (C): INTRAOPERATIVE FROZEN SECTION DIAGNOSIS: BENIGN FINAL DIAGNOSIS: BENIGN URETHRAL MUCOSA NO DYSPLASIA OR CARCINOMA IDENTIFIED BLADDER, PROSTATE (D): BLADDER : INTRAOPERATIVE GROSS CONSULTATION: TUMOR IDENTIFIED A T3S, Aguamous = O? FINAL DIAGNOSIS: UROTHELIAL CARCINOMA WITH SARCOMATOID FEATURES, POORLY DIFFERENTIATED, GRADE 4/4, INFILTRATING THROUGH THE MUSCULARIS PROPRIA TO THE PERIVESICAL FAT, BUT NOT AT THE MARGINS LYMPHOVASCULAR INVASION IDENTIFIED SURGICAL MARGINS, FREE OF MALIGNANCYS MULTIFOCI OF UROTHELIAL CARCINOMA IN~SITU IDENTIFIED CHRONIC CYSTITIS PROSTATE: RIGHT PROSTATIC ADENOCARCINOMA, GLEASON'S SCORE 6 (3 + 3), CONFINED TO THE PROSTATE HIGH GRADE PROSTATIC INTRAEPITHELIAL NEOPLASIA (PIN III), MULTIFOCAL EXTENSIVE PROSTATIC ATROPHY WITH ACUTE AND CHRONIC INFLAMMATION ALL THE SURGICAL MARGINS, FREE OF MALIGNANCY PERIVESICAL LYMPH NODES:S NO METASTATIC CARCINOMA IDENTIFIED IN 13 LYMPH NODES EXAMINED (0/13)) LEFT PARA AORTIC LYMPH NODES (E) :  NO METASTATIC CARCINOMA IDENTIFIED IN SIX LYMPH NODES EXAMINED (0/6) LEFT COMMON ILIAC LYMPH NODES (F) : NO METASTATIC CARCINOMA IDENTIFIED IN 15 LYMPH NODES EXAMINED (0/15)) RIGHT PARA CAVAL LYMPH NODES (G) : NO METASTATIC CARCINOMA IDENTIFIED IN FOUR LYMPH NODES EXAMINED (O/4) RIGHT COMMON ILIAC LYMPH NODES (H) : NO METASTATIC CARCINOMA IDENTIFIED IN 24 LYMPH NODES EXAMINED (0/24)
+
+--- Page 2 ---
+Page 2 of 6 RIGHT LYMPH NODE OF CLOQUET (I):  NO METASTATIC CARCINOMA IDENTIFIED IN THREE LYMPH NODES EXAMINED (O/3) RIGHT EXTERNAL ILIAC LYMPH NODES (J) :  NO METASTATIC CARCINOMA IDENTIFIED IN FOUR LYMPH NODES EXAMINED (O/4) RIGHT OBTURATOR/HYPOGASTRIC LYMPH NODES (K) :) NO METASTATIC CARCINOMA IDENTIFIED IN 38 LYMPH NODES EXAMINED (0/38) LEFT LYMPH NODE OF CLOQUET (L):) NO METASTATIC CARCINOMA IDENTIFIED IN THREE LYMPH NODES EXAMINED (O/3) LEFT EXTERNAL ILIAC LYMPH NODES (M) : NO METASTATIC CARCINOMA IDENTIFIED IN TWO LYMPH NODES EXAMINED (O/2)) LEFT OBTURATOR/HYPOGASTRIC LYMPH NODES (N) :) METASTATIC CARCINOMA IDENTIFIED ONE OF 42 LYMPH NODES EXAMINED (1/42) RIGHT PRE SCIATIC LYMPH NODES (O) :)  NO METASTATIC CARCINOMA IDENTIFIED IN THREE LYMPH NODES EXAMINED (O/3)) PRE SACRAL LYMPH NODES (P) :)  NO METASTATIC CARCINOMA IDENTIFIED IN NINE LYMPH NODES EXAMINED (O/9) LEFT PRE SCIATIC LYMPH NODES (Q): NO METASTATIC CARCINOMA IDENTIFIED IN FOUR LYMPH NODES EXAMINED (O/4) RIGHT PROXIMAL URETER (R) : BENIGN URETER  NO DYSPLASIA OR CARCINOMA IDENTIFIED LEFT PROXIMAL URETER (S) : BENIGN URETER  NO DYSPLASIA OR CARCINOMA IDENTIFIED TOTAL LYMPH NODES:  METASTATIC CARCINOMA IDENTIFIED ONE OF 170 LYMPH NODES EXAMINED (1/170) PATHOLOGY AJCC STAGE (5TH EDITION) : BLADDER: pTis, T3aNIMX PROSTATE: pT2aN1MX Electronically signed by Verified: COMMENT: The case was discussed with Dr.. on Immunohistochemical stains for synaptophysin, chromogranin and pancytokeratin on D9 show the neoplastic cell in the bladder are positive for pancytokeratin and. vimentin, and negative for synaptophysin and chromogranin, which support the diagnosis of urothelial carcinoma with sarcomatoid features. Immunostains for CK 903' and racemase on 19 and D22 support the diagnoses of prostatic adenocarcinoma.. SPECIMEN SOURCE: A: "Right distal ureter" B: "Left distal ureter" C: "Apical urethral margin-f/s".
+
+--- Page 3 ---
+Page 3 of 6 Ordereo "Bladder. prostate" D E: "Left para aortic LN" F: "Left common iliac LN" G: "Right para caval LN" H: "Right common iliac LN" I: "Right LN of Cloquet" "Right external iliac LN" K: "Right obturator hypogastric LN". L: "Left LN of Cloquet' M: "Left external iliac LN' N: "Left obturator hypogastric LN" O: "Right pre sciatic'LN" P: "Pre sacral LN" Q: "Left pre sciatic LNn R: "Right proximal .ureter" S: "Left proximal ureter" CLINICAL INFORMATION: Pre-op Dx: Bladder cancer Post-op Dx: Same as pre-op GROSS EXAMINATION: A: The specimen is received fresh from the O.R. and labeled "Right distal ureter" It consists of a segment of soft tubular gray tissue measuring 0.2 cm in length x 0.3 cm in diameter.  The specimen is entirely submitted for frozen section in Ars. B: The specimen is received fresh from the O.R. and labeled "Left distal ureter". It consists of a segment of soft tubular gray tissue measuring 0.2 cm in length x 0.4 cm in diameter.  The specimen is entirely submitted for frozen section in BFs. C: The specimen is received fresh from the O.R. and labeled "Apical urethral margin-f/s". It consists of a piece of soft pink tissue measuring 1.5 x 0.3 x 0.2 cm. The specimen is entirely submitted by for frozen section diagnosis in cFs. D: The specimen is received fresh from the o.R. and labeled "pladder, prostate". The specimen overall measures 32 x 16.5 x 5.5 cm and is partially covered in a shiny, fatty, yellow-pink peritoneum measures 26.5 x 15.5 x less than 0.1 cm. The specimen consists of a bladder (15 x 9 x 5.s cm) and attached prostate (5 x 4.2 x 3.3 cm). The right attached seminal vesicle measures 3.7 x'1.8 x 0.6 cm and the left attached seminal vesicle measures 3.3 x 1.5 x 0.8 cm.  The surgical margin of the entire specimen is inked black, with the right side inked with superimposed red.  The specimen is opened along the anterior urethra revealing a prostatic urethra measuring 3 cm in length x 3 cm in circumference. The verumontanum measures 1.3 x 0.3 x 0.2 cm. The urethral mucosa is pink-tan, smooth, and does -not appear to be excavated.  The bladder is almost entirely filled by huge, necrotic, bloody, friable, soft, exophytic mass which measures 14.5 x 8'x 5 cm.  The mass appears to arise from the left lateral wall. Upon sectioning through the mass, the cut surfaces are coagulative, solid, soft and ranges in color from red to yellowish in a marbled pattern. Upon sectioning through the mass's relationship to the left lateral wall, it appears to arise from the solid, firm, light tan mass at the base and to extend into the bladder wall but not involve the underlying perivesical fat. The tumor appears to be 1 cm from the inked black margin. Bilateral attached ureters are opened.. The right ureter measures 6 cm in length x 1.2 cm in circumference and the left ureter measures 7.3 cm in length x i.1 cm in circumference. The ureteral mucosa are both grossly unremarkable. The remaining bladder mucosa is gray, congested, and grossly unremarkable elsewhere, except for the trigone where there is a firm nodularity.. The specimen is taken to the o.R. in. a gross consultation. The urothelium is fixed in Bs fixative for an hour and the specimen is subsequently entirely fixed in formalin. The prostate is serially sectioned from distal to proximal, revealing smooth, solid, grossly unremarkable,
+
+--- Page 4 ---
+Page 4 of 6 Orderedby light yellow cut surfaces. No gross tumors are noted in the prostate. NO perivesical lymph nodes are palpated. Representative sections are submitted in 24. cassettes. E:  The specimen is received in formalin and labeled "Left para aortic LN". consists of fibrofatty and lymphoid tissue measuring in aggregate 2.5 x 2.3 x 0.8 cm. Entirely submitted in three cassettes. F The specimen is received in formalin and labeled "Left common iliac Ln". It consists of multiple fragments of fatty and lymphoid tissue measuring in aggregate. 3.5 x 2.5 x 0.4 cm. Entirely submitted in three cassettes. G: The specimen is received in formalin and labeled "Right para caval LN". It consists of fatty and lymphoid tissue measuring in aggregate 4.5 x 2.5 x 0.5 cm. Entirely submitted in two cassettes.  The specimen is received in formalin and labeled sRight common iliac LN". It consists of multiple fragments of fatty and lymphoid tissue measuring in aggregate 5.5 x 3.5 x 1 cm. Entirely submitted in five cassettes. I: The specimen is received in formalin and labeled "Right LN of Cloquet". It consists of a lymph node measuring 2 x 1.8 x 0.7 cm.  Serially sectioned and entirely submitted in two cassettes. J: The specimen is received in formalin and labeled "Right external iliac LNa. It consists of multiple fragments of fatty and lymphoid tissue measuring in aggregate 5 x 2.5 x 1 cm. Entirely submitted in three cassettes. K: The specimen is received in formalin and labeled Right obturator hypogastric LN".  It consists of multiple fragments of fatty and lymphoid tissue measuring in aggregate 7 x 5 x 1.5 cm. Entirely submitted in seven cassettes.. L: The specimen is received in formalin and labeled "Left LN of Cloquet". consists 0f a single lymph node measuring 1.4 x 0.9 x 0.9 cm, with a small amount of attached fat. Serially sectioned and entirely submitted in one cassette. M: The specimen is received in formalin and labeled "Left external iliac LN'. It. consists of multiple fragments of fatty and lymphoid tissue measuring in aggregate 4.2 x 2 x o.5 cm.' Entirely submitted in two cassettes. N  The specimen is received in formalin and labeled #Left obturator hypogastric LN". It consists of multiple fragments of fatty and lymphoid tissue measuring in aggregate 7.2 x 4 x 0.8 cm. Entirely submitted in seven cassettes. O: The specimen is received in formalin and labeled "Right pre sciatic LN". It consists of multiple fragments of fatty tissue measuring in aggregate 2 x 2 x 0.3 cm. Entirely submitted in one cassette. P:  The specimen is received in formalin and labeled "pre sacral LN". It consists of multipie fragments of fatty and lymphoid tissue measuring in aggregate 4 x 2 x 0.5 cm. 'Entirely submitted in two cassettes. Q  The specimen is received in formalin and labeled "Left pre sciatic LN". It consists of multiple fragments of fatty and lymphoid tissue measuring in aggregate 3.5 x 2 x 0.3 cm. Entirely submitted in one cassette. R: The specimen is received in formalin and labeled "Right proximal ureter". It. consists of a segment of gray-purple tubule measuring o.3 cm in length x 0.3 cm in diameter. Serially sectioned and entirely submitted in one cassette. There are staples evenly spaced across it.
+
+--- Page 5 ---
+Page 5 of 6 order S:  The specimen is received in formalin and labeled 'Left proximal ureter".. It consists of a segment of pink-gray tubule measuring 0.3 cm in length x 0.4 cm in diameter. The specimen is stapled evenly across.  Serially sectioned and entirely submitted in one cassette.. SECTIONS: AFS: frozen section, right distal ureter Bes: frozen section, left distal ureter. CFs: frozen section, apical urethral margin D1: posterior wall of bladder D2 : dome of bladder D3: right lateral wall of bladder D4 5: anterior wall of bladder D6: right ureterovesical junction, plus representative sections through ureter D7 : left ureterovesical junction, plus representative sections through ureter D8: trigone D9-12: representative sections through tumor in relationship to the left lateral  wall D13: relationship of tumor to closest inked margin D14, 15: representative sections through the hemorrhagic bladder mass D16: right distal prostate D17: left distal prostate D18: right mid prostate D19: left posterior mid prostate D20: left anterior mid prostate D21: right posterior proximal prostate. D22: right anterior proximal prostate D23 : left posterior proximal prostate D24 : left anterior proximal prostate E1: left para aortic lymph nodes; one lymph node, bisected E2: two lymph nodes, one inked black, both bisected E3 : remaining tissue F1, 2: left common iliac lymph nodes; lymphoid tissue F3 : remaining tissue G1 : right para caval lymph nodes; one lymph node, bisected G2 : remaining tissue H1. 2: right~common iliac lymph nodes; each contain one lymph node, bisected H3: two lymph nodes, bisected, one inked black H4 : remaining lymphoid tissue H5: remaining tissue I1, 2: right lymph node of Cloquet; one lymph node, serially sectioned J1 : right~external iliac lymph nodes; one'lymph node, bisected J2 : remaining lymphoid tissue J3 : remaining tissue K1: right obturator hypogastric lymph nodes; one lymph node, bisected K2-4 : remaining lymphoid tissue K5-7: remaining tissue L1: left lymph node of Cloquet; one lymph node, serially sectioned M1: left external iliac lymph nodes; one lymph node, bisected m2 : remaining tissue N1, 2: left obturator hypogastric lymph nodes; each contain one half of one lymph node, bisected N3 : one lymph node, bisected N4-6: remaining lymphoid tissue N7 : remaining tissue 0: right pre sciatic lymph nodes P1: pre sacral lymph nodes; lymphoid tissue P2 : remaining tissue Q: left pre sciatic lymph nodes
+
+--- Page 6 ---
+Page 6 of 6 SURCICA R: right proxima s: left proximal ureter INTRAOPERATIVE FROZEN CONSULTATION: AFS: Right distal ureter benign BFS: Left distal ureter benign cFs: Apical urethral margin benign INTRAOPERATIVE GROSS CONSULTATION Bladder, prostate (D): tumor identified MICROSCOPIC EXAMINATION: A-S: See final microscopic diagnosis.
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diff --git a/output/text/ce394169-9f6c-4383-986b-ed2f96d9d45c.txt b/output/text/ce394169-9f6c-4383-986b-ed2f96d9d45c.txt
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index 0000000000000000000000000000000000000000..4c0a05256eac5635c4c65eb9b92685a5493b7110
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+FINAL DIAGNOSIS: PARt 1: LEft SEntinel Lymph nODe #1, BIOpSy -- ONE LYMPH NODE NEGATiVE FOR TUMOR (0/1). Part 2: Left Sentinel Lymph nOde #2, biOpsy -- One Lymph nODe negative fOr tumor (0/1). 1cs-0-3 Curcioma nfItrnHrg ductol, Nos 85Oof3 PaRt 3: Left Sentinel Lymph nODe #3, bIOpSy - ONE LYMPH nODe NEgATIVE fOR TUMOR (0/1) Sit : bresst, Nos c50.9 3131 Part 4: Skin Of Left breast, ExciSiOn - SKIn WITh FIBROSiS. Part 5: Left breast, Segmental mastectomy - A. iNFILTRATING DUCT CARCINQMA 1.0 X 1.0 X 0.9 CM ASSOCIATED WITH MICROCALCIFICATIONS. B. NOt tingham'scORe 6 Out Of 9 (tubules 3, nucleI 2, mItosis 1). C.  NO LYMPHOVASCULAR INVASION IDENTIFIED. D. DUCTAL CARCINOMA IN-SITU, CRIBRIFORM TYPE, NUCLEAR GRADE 2 COMPRISiNG 1% OF INVASIVE TumOR. E.  SURGICAL MARGINS NEGATIVE. F. CLOSEST MARGIN AnTERiOR-0.4 CM. G.  CHANGES CONSISTENT WITH PREVIOUS CORE BiOPSY SITES.E H.  TUMOR IS ESTROGEN RECEPTOR POSITIVE, PROGESTERONE RECEPTOR POSITIVE AND HER-2/NEU  Negative as per core biopsy report. FIBROCYSTIC CHANGES, FIBROADENOMATOID NODULES AND MICROCALCIFICATIONS ASSOCIATED With benign Ducts. J. THERMAL EFFECT. Part 6: Left Breast, new inferiOr margin, resectiOn --  NEgative fOr tumor. Part 7: Left Breast, excision Of fibroadenoma -- A.  FIBROADENOmA. B. CHANGES CONSISTENT WITH PREVIOUS CORE BIOPSY SITE. CASE SYNOPSIS:  SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST Laterality: PROCEDURE: Left  Segmental LOCATION: SIZE OF TUMOR: Not specified Maximum dimension invasive component: 1.0 cm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: TUMOR TYPE (invasive component): No NOTTINGHAm SCORE: Ductal adenocarcinoma, NOS Nuclear grade: 2 UUID:DDAB2FC2-D9F0-4D8F-A7FE-6C0B823E6823 Tubule formation: 3 TCGA-BH-A0BO-01A-PR Redacted Mitotic activity score: 1 Total Nottingham score: 6. ANGIOLYMPHATIC INVASION: Nottingham grade (1, 2, 3): 2 DERMAL LYMPHATIC INVASION: No CALCIFICATION: No Yes, benign zones Tumor type, In SiTu: Yes, malignant zones Cribriform  SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:E Percent of tumor occupied by in situ component: 1 % SURG MARGINS INVOLVED BY IN SITU COMPONENT: No LYMPH NODES POSITIVE: No LymPH NODES EXAMINED: 0 METHOD(S) OF LymPH NODE EXAMINATION: 3 SENTINEL NODE METASTASIS: H/E stain, Keratin stain NON-NEOPLASTIC BREAST TISSUE: Fibroadenoma, FCD No t stage, pathologic: N stage, pathologic: pT1b m Stage, pathologic: pNO EStrOgen rECePTOrS: pMX Criterla PROGESTERONE RECEPTORS: positive Diag positive HER2/NEU: zero or 1+ 3/3/r
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diff --git a/output/text/ce56e0d5-91ad-4b80-8a3e-6c23a798f58d.txt b/output/text/ce56e0d5-91ad-4b80-8a3e-6c23a798f58d.txt
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index 0000000000000000000000000000000000000000..69c31b6d9593d0e1bd1b291db72f82971041d5c7
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+--- Page 1 ---
+FINAL DIAGNOSIS: part 1: breast. Leet, segmental mastectomy - A.  iNVASIVE DUCTAL CARCInOMA, nOTTINGhAm GRADE 2 (TUBULE fORmATION - 3, NUCLEAR GRADE - 2, Mitotic rate - 2; total score 7/9). B. iNVASIVE CARCiNOmA MEASURES 2.0 Cm In GREATESt DIMENSION. C. DUCTAL CARCiNOMA IN-SITU (DCiS), NUCLEAR GRADE 2-3, CRIBRIFORM, SOLID AND MICROPAPILLARY Type, WITh COmeDONecROSiS. D. DCIS IS PRESENT ADMIXED AND OUTSIDE OF THE INVASIVE COMPONENT IN 8 OUT OF 19 SLIDES AND COmpRiSes APprOxImAtely 50% Of the tOtal tumOr VOlumE. E. NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED. F. MARGINS OF RESECTION ARE NEGATIVE FOR INVASIVE COMPONENT, WITH ALL THE MARGINS BEING MORE THAN 1 CM AWAY. G. MARGINS OF RESECTION ARE NEGATIVE FOR DCIS; HOWEVER, DCIS IS LESS THAN 1 MM FROM ANTERIOR mARGIN AND 1.5 mm FROm POSTERIOR MARGIN OF RESECTION. H. FiBROCYSTIC CHANGES WITH FIBROADENOmATOID NODULE. I. BIOPSY SITE CHANGES. J. INVASIVE TUMOR CELLS ARE WEAKLY POSITIVE FOR ESTROGEN RECEPTOR, NEGATIVE FOR PROgESTErONe RECEPtOR, AND POSITIVe fOR hER-1/NEU (SCORE 3+), AS PER PReVIOUS PATHOLOGY REPORT Part 2: Left Axillary lymph node, Dissection - A.TWO OUt OF TWeLVE Lymph nODeS, POSITIVE fOR MEtaStaTiC CArcInOmA (2/12). B.the Size Of the LArgest metastasis is Over 2 Cm (see comment). NO.EXTRACAPSULAR EXTENSION IS SEEN. CASE SYNOPSIS: 1cs-0 -3 SYNOPTiC - PRIMARY iNVASIVE CARCINOMA OF BREAST curcmomn,mnfiYtnsHny ouct!, Nos 85oof3 LATERALITy: Left PROCEDURE: Srtx: buut, Nos C50.9 3/13  Segmental LOCATION: Not specified SIZE OF TUMOR:  Maximum dimension invasive component: 2.0 cm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: No TUMOR TYPE (invasive component): Ductal adenocarcinoma, NOS NOTTINGHAM SCORE: Nuclear grade: 2 Tubule formation: 3 Mitotic activity score: 2 Total Nottingham score: 7 Nottingham grade (1, 2, 3): 2 ANGIOLYMPHATIC INVASION: No DERMAL LYMPHATIC INVASION: Not applicable CALCIFICATION: No Tumor type, In situ: Cribriform Solid  Micropapillary DCIS admixed and outside of invasive carcinoma component Percent of tumor occupied by in situ component: 50 % SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No SURG MARGINS INVOLVED BY IN SITU COMPONENT: No Distance of in situ disease to closest margin: 1 mm LYMPH NODES POSITIVE: 2 LyMPH nODES EXAMINED: 12 METhOD(S) OF LymPH nODE EXAmInATION:  H/E stain SIZE OF NODAL METASTASES: Diameter of largest lymph node metastasis: 20 mm LYMPH NODE METASTASIS(-ES) WITH EXTRACAPSULAR EXTENSION: No t Stage, pathologic: pT1c N Stage, pathologIC: pN1a m Stage, patholOgIc: pMX ESTROGEN RECEPTORS: positive PROGESTERONE RECEPTORS: negative HER2/NEU: 3+ UUID:D1B30DA1-FF63-4FC7-AB8B-818331EE6072 TCGA-BH-A0AW-01A-PR Redacted
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diff --git a/output/text/ce5e7f83-db37-446a-b159-763bc7d7c6e5.txt b/output/text/ce5e7f83-db37-446a-b159-763bc7d7c6e5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d8ef7694d8abc993378884269b48c3a74a7ac1ef
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+
+--- Page 1 ---
+Tumor entity (in block A) Colic adenocarcinoma with characteristic solid and ductal cell elements, with loss of cell.  nucleus polarity and increased chromatin image.. Invasion of around 1 cm with infiltration of the bordering fatty connective tissue (pT3) Tumor classification (TNM, 6th edition) Stage grouping ICDO-DA M-8140/3 G2 pT3, pN0, MX, L1, V1 RO
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diff --git a/output/text/ce668b52-f343-468e-978b-1d6c64e5f3ac.txt b/output/text/ce668b52-f343-468e-978b-1d6c64e5f3ac.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d342a32390700ae38d2f39fa872fabbecead5758
--- /dev/null
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@@ -0,0 +1,21 @@
+
+--- Page 1 ---
+UUID:D7E24E6B-797F-4FC9-B0FB-794C4D379091 TCGA-S3-AA17-01A-PR Redacted MRN: Patient: Sex/DOB: Female Admission Date: Discharge Date: Ordering Physician: Pathology Addendum Report Collected Date/Time: Accession Number: Received Date/Time: Addendum Report Immunohistochemical studies for E-cadherin (Block D2), p63 (Blocks D2-4)and calponin (Blocks D3-4)were performed on formalin fixed, paraffin-embedded tissue with adequate positive and negative control sections. Stains are positive, supporting the above diagnosis. The performance characteristics of these antibodies were determined by the clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for rescarch. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA-88) as qualified to perform high-complexity clinical laboratory testing. ydLeetNoS 85Oof3 weenoma (Electronic signature) t ros 050.9 St Verified: ka tbEKuast Locs-outer guadiart C5o 5 )OUz/24[14 Surgical Pathology Report Collected Date/Time: Accession Number: Received Date/Time: Final Diagnosis A.RIGHT SENTINEL LYMPH NODES, EXCISION: - ONE OUT OF TWO LYMPH NODES POSITIVE FOR CARCINOMA WITH MICROMETASTASIS; SEE NOTE - KERATIN STAIN HIGHLIGHTING ONE LYMPH NODE WITH SCATTERED TUMOR CELLS B. RIGHT BREAST, MASTECTOMY: - INVASIVE DUCTAL CARCINOMA, GRADE 3; SEE SYNOPSIS - NEGATIVE MARGINS - RADIAL SCAR, COLLAGENOUS SPERULOSIS AND BIOPSY SITE CHANGES Printed by: Page I of 7 Print Date/Time: Copied to: : Distribute to: Patient Locations:
+
+--- Page 2 ---
+MRN: Sex/DOB: Female Patient: Surgical Pathology Report Collected Date/Time: Accession Number:d Received Date/Time: - NIPPLE AND SKIN WITHOUT SIGNIFICANT PATHOLOGIC ABNORMALITYS C. LEFT SENTINEL LYMPH NODE, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR CARCINOMA - NEGATIVE KERATIN STAINS D. LEFT BREAST, MASTECTOMY: - EXTENSIVE DUCTAL CARCINOMA IN SITU, GRADE 2, WITH CRIBIFORM AND SECONDARY INVOLVEMENT OF PREEXISTING PAPILLOMA AND RADIAL SCAR; MEASURING APPROXIMATELY 25 CM  - SKIN AND NIPPLE WITHOUT SIGNIFICANT PATHOLOGIC ABNORMALITYS NOTE: Right sentinel lymph node involved by carcinoma cells are present scattered in a noncontiguous manner of at least half of the perimeter with isolated small clusters (< 0.2mm). Although measurements do not categorically classify these as a micrometastasis, tbe tumor load could be greater than just isolated tumor cells. According to the AJCC," if more than 200 individual tumor cells are identified as single dispersed cells or as a nearly confluent elliptical or spherical focus in a single  histologic section of a lymph node there is a high probability that more than 1,000 cells are present in the lymph node. In these situations, the node should be classified as containing a micrometastases ".. Reference: Cancer Staging Manual. AJCC, 7th edition(2110), New York, p356. (Electronic signature) Verified: Synoptic Report SPECIMEN: Total breast (including nipple and skin). PROCEDURE: Total mastectomy (including nipple and skin) LYMPH NODE SAMPLING: Sentinel lymph node(s) SPECIMEN INTEGRITY: Single intact specimen (margins can be evaluated) SPECIMEN SIZE: Greatest dimension: 29.0 cm Additional dimensions: 21.0 x 8.0 cm SPECIMEN LATERALITY: Right TUMOR SITE: INVASIVE CARCINOMA: Lower outer quadrant (7:00-9:00) TUMOR SIZE: SIZE OF LARGEST INVASIVE CARCINOMA: Greatest dimension of largest focus of invasion over 0.1 cm: 4.0 cm. Additional dimensions: 3.0 x 3.0 cm TUMOR FOCALITY: Single focus of invasive carcinoma. Page 2 of 7 Print Date/Time:
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+MRN: Patient: Sex/DOB:  Female Surgical Pathology Report Collected Date/Time: Accession Number: Received Date/Time: MACROSCOPIC AND MICROSCOPIC EXTENT OF TUMOR: Skin: Invasive carcinoma does not invade into the dermis or epidermis Nipple: DCIS does not involve the nipple epidermis Skeletal Muscle: No skeletal muscle present -. DUCTAL CARCINOMA IN SITU (DCIS): No DCIS is present LOBULAR CARCINOMA IN SITU (LCIS): Not identified HISTOLOGIC TYPE OF INVASIVE CARCINOMA: Invasive ductal carcinoma (no special type or not otherwise specified) GLANDULAR (ACINAR)/TUBULAR DIFFERENTIATION: Score 3: <10% of tumor area forming glandular/tubular structures NUCLEAR PLEOMORPHISM: Score 3: Vesicular nuclei, often with prominent nucleoli, exhibiting marked variation in size and shape, occasionally with very large and bizarre forms MITOTIC COUNT: Score 3 Number of mitoses per 10 high-power fields: 25 Diameter of microscope field: 0.55 mm OVERALL GRADE: Grade 3: scores of 8 or 9 MARGINS:  Margins uninvolved by invasive carcinoma Distance from anterior margin: 10.0 mm Distance from posterior margin: 40.0 mm LYMPH-VASCULAR INVASION: Not identified DERMAL LYMPH-VASCULAR INVASION: Not identified LYMPH NODES: Number of sentinel lymph nodes examined: 2 Number of lymph nodes with macrometastases (>0.2 cm): 0 Number of lymph nodes with micrometastases (>0.2 mm to 0.2 cm and/or >200 cells): 1 METHOD OF EVALUATION OF SENTINAL LYMPH NODES: H&E, multiple levels Immunohistochemistry PRIMARY TUMOR (INVASIVE CARCINOMA (pT): pT2: Tumar >20 mm but less than or equal to 50 mm in greatest dimension REGIONAL LYMPH NODES (pN):  pN1mi: Micrometastases (greater than 0.2 mm and/or more than 200 cells, but none greater than 2.0 mm).. DISTANT METASTASIS (M): Not applicable ESTROGEN RECEPTOR: Performed on another specimen Immunoreactive tumor cells present (greater than or equal to 1%) Quantitation: 100% Page 3 of 7 Print Date/Time:
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+MRN: Sex/DOB: Female Patient:  Surgical Pathology Report Accession Number: Collected Date/Time: Received Date/Time: PROGESTERONE RECEPTOR: Performed on another specimen. Immunoreactive tumor cells present (greater than or.equal to 1%) Quantitation: 70% HER2/NEU IMMUNOPEROXIDASE STUDIES: Performed on another specimen Equivocal (Score 2+) FLUORESCENCE IN SITU HYBRIDIZATION (FISH) FOR HER2/NEU: Performed on another specimen. Not amplified (HER2 gene copy <4.0 or ratio <1.8) SPECIMEN: Total breast (including nipple and skin) PROCEDURE: Total mastectomy (including nipple and skin) LYMPH NODE SAMPLING: Sentinel lymph node(s) SPECIMEN INTEGRITY: Single intact specimen SPECIMEN SIZE: Greatest dimension: 19.0 cm Additional dimensions: 13.0 x 8.0 cm SPECIMEN LATERALITY: Left TUMOR SITE: Lower inner quadrant ((6:00-8:00)) SIZE (EXTENT) OF DCIS: Estimated size (extent) of DCIS: at least 2.5 cm Number of blocks with DCIS: 6 Number of blocks examined: 10 HISTOLOGIC TYPE: Ductal carcinoma in situ. Classified as Tis (DCIS) or Tis (Paget). ARCHITECTURAL PATTERNS: Cribriform Papillary NUCLEAR GRADE: Grade II (intermediate) NECROSIS: Not identified MARGINS: Margin(s) uninvolved by DCIS *Distance from posterior margin: 7.0 mm LYMPH NODES: Number of sentine! nodes examined: 1 Number of lymph nodes with macrometastases (>0.2 cm): 0 Number of lymph nodes with micrometastases (>0.2 mm to 0.2 cm and/or >200 cells): 0 Page 4 of 7 Print Date/Time:
+
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+MRN: Patient: Sex/DOB: Female Surgical Pathology Report Collected Date/Time: Accession Number: Received Date/Time: Number of lymph nodes with isolated tumor cells (less than or equal to 0.2 mm and less than or equal to 200 cells): 0 METHOD OF EVALUATION OF SENTINEL LYMPH NODES: H&E, multiple levels Immunohistochemistry PRIMARY TUMOR (Invasive Carcinoma) (pT): pTis (DCIS): Ductal carcinoma in situ REGIONAL LYMPH NODES (pN):  pNO: No regional lymph node metastasis histologically DISTANT METASTASIS (M): Not applicable ANCILLARY STUDIES: Estrogen Receptor (results of special studies performed on this specimen or a prior core needle biopsy) Immuncreactive tumor cells present  Progesterone Receptor (results of special studies performed on this specimen or a prior core needle biopsy) Immunoreactive tumor cells present MICROCALCIFICATIONS: *Present in both DCIS and non-neoplastic tissue Source of Specimen A Lymph Nodes, Rt. Sentinel B Right Breast c Lymph Nodes, Sentinel Lefte D LT Breast Clinical Information PRE-OP DIAGNOSIS: Bilateral breast cancer POST-OP DIAGNOSIS: Same TYPE OF PROCEDURE: Bilateral mastectomy, Sentinel node biopsy Gross Description Specimen is received in 4 parts: A.The specimen is labeled "RIGHr SENTINEL NODE" and is received unfixed of a resection diagnosis. (The specimen is in the. formalin more than 6 hours and less than 48 hours). It consists of 4 x 3 x I cm fragment of fatty tissue which reveals 2.5 x 1.5 x 1 cm and 1 x 0.8 x 0.7 cm lymph nodes. Each lymph nodes bisected and entirely submitted as follows: FS A1 = smaller lymph node FS A2-FSA 3 = larger lymph node Time specimen was removed from the patient: Time specimen was placed in formalin : Ischemic time: 20 minutes Page 5 of 7 Print Date/Time:
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+MRN: Sex/DOB: Patient: Female Surgical Pathology Report Accession Number: Collected Date/Time: Received Date/Time: B. The specimen is labeled "RIGHr BREAST " and is received in formalin. (The specimen is in the formalin more than 6 hours and less than 48 hours). It consist of mastectomy specimen with lymph nodes weighing 1010 grams and mcasuring 29 x 21 x 8 cm with brown skin ellipse measuring 20 x 9 cm, containing grossly unremarkable 1.3 cm in diameter nipple. The skin is tagged with a black stitch designating 12:00 . The posterior margin is composed of smooth fascia which is inked black. The breast is slices in sagittal planes revealing 4 x 3 x 3 cm an ill-defined mass approximately 7:00 to 9:00 position. This mass is 1 cm underneath the skin surface and 4 cm away from the deep fascial margin of resection. On sectioning between 12:00 to 1:00 position focal area of hemorrhage and 0.7 x 0.5 x 0.5 cm ill-defined firm area is noted which is 2 cm away from the deep fascial margin of resection and 7 cm away from the 7:00-9:00 mass.. The remaining portions revealed unremarkable yellow mammary fat with streaks of white-gray. mammary parenchyma. Representative sections estimated as follows: B1 = nipple B2-B5 = 7:00-9:00mass  B6 = 7:00-9:00 mass closest deep fascial margin of resection B7-B9 = 12:00-1:00 hemorrhagic area B10 = 12:00-1:00 ill-defined firm area  B11 = 12:00-1:00 ill-defined firm area closest deep fascial margin of resection B12 = random section between 7:00-9:00 and 12:00-1:00.  B13 = upper inner quadrant B14 = upper outer quadrant B15 = lower outer quadrant B16 = lower inner quadrant Time specimen was removed from the patient: Time specimen was placed in formalin : Ischemic time: 1/5 minutes C. The specimen is labeled "LEFT SENrINEL NODE" and is received unfixed for frozen section diagnosis. (The specimen is in the formalin more than 6 hours and less than 48 hours). It consists of a 2 x 1.5 x 1 cm fragment of lobulated fatty tissue which reveal I x 0.8 x 0.7 cm lymph node. Lymph node is bisected and entirely submitted in cassette FSC 1. Time specimen was removed from the patient: Time specimen was placed in formalin : Ischemic time: 18 minutes D. The specimen is labeled "LEFr BREAST " and is received in formalin. (The specimen is in the formalin more than 6 hours and. less than 48 hours). It consist of mastectomy specimen without lymph nodes weighing 1040 grams and measuring 13 x 19 x 8 cm with brown skin ellipse measuring 20 x 9 cm, containing grossly unremarkable 1.2 cm in diameter nipple. [The skin is tagged with a black stitch designating 12:00 ]. The posterior margin is composed of smooth fascia which is inked black. The treast is slices in sagital planes revealing multiple white-tan firm nodules ranging from 0.5-0.7 cm in greatest diameter and measuring 2.5 x 2 x 2 cm in aggregate. These nodules are located between 6:00 to 8:00 position and are 0.7 cm away from the closest deep fascial margin of resection. The remaining portions reveal unremarkable yellow mammary fat with steaks of white-gray mammary parenchyma.. Representative sections are submitted as follows: B1 =nipple D2-D6 = multiple nodules between 6:00 8:00 position D7 = 6:00-8:00 position nodules closest deep fascial margin of resection D8 = upper outer quadrant D9 = upper inner quadrant D10 = lower inner quadrant Page 6 of 7 Print Date/Time:
+
+--- Page 7 ---
+MRN: Patient: Sex/DOB:Female. Surgical Pathology Report Collected Date/Time: Accession Number: Received Date/Time: D11 = lower outer quadrant Time specimen was removed from the patient: Time specimen was placed in formalin : Ischemic time: 20 minutes Dictated by: Intra Qperative Consultation A. Right sentinel node = 2 lymph nodes, negative for carcinoma, fatty lymph node C. Left sentinel node =- one lymph node negative for carcinoma Tissue Code wi Page 7 of 7
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diff --git a/output/text/ce7fa43c-6376-4144-b200-a64f08ccd954.txt b/output/text/ce7fa43c-6376-4144-b200-a64f08ccd954.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4e28c40852bf9e4517ba2a62ed8c3a30f95d19c6
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+SUPPLEMENTAL REPORT DIAGNOSIS: (A)TOTAL LAryNgECTOMy: Hyoid bone and thyroid cartilage, no invasion by tumor.. COMMENT: This supplemental report is issued. to give the diagnosis on specimens requiring decalcification. This report does not change any of the diagnoses given on the previous report.. DIAGNOSIS A  TOTAl LARYNGECTOMY: MODERATELY DIFFERENTIATED SQUAMOUS CARCINOMA OF LARYNX INVOLVING RIGHT SUPRAGLOTTIC REGION, BASE OF RIGHT SIDE OF EPIGLOTTIS, RIGHT FALSE VOCAL CORD AND FOCALLY RIGHT TRUE VOCAl CORD. (see cOmmenT) Margins of resection (mucosal, soft tissue, tracheal), free of tumor. Hyoid bone and thyroid cartilage, diagnosis pending decalcification. COMMENT The squamous carcinoma measures 1.5 x 1.3 x 0.7 cm in greatest. tumor is identified. SPECIMEN (A)  TOTAL LARYNGECTOMY: SNOMED CODES T-24100,M-80703 Page 1 of 1 History Case Pathology Report History Case Pathology. File under: Pathology
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diff --git a/output/text/ce88bf5d-fe35-470f-83bd-8c36baa0b8bc.txt b/output/text/ce88bf5d-fe35-470f-83bd-8c36baa0b8bc.txt
new file mode 100644
index 0000000000000000000000000000000000000000..16df25720d417e8a0e85e81af2574fd017b0a90a
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+tcD-o3 Melsnrns, yiteliseol Lepurslle cell UUID: 5D2ABEAA-D18A-4B35-BBAF-9E1B34D0E07C  Redacted TCGA-V4-A9F4-01A-PR 8 776%3 mijsel Sut CrorssL c4Y.3 etlvl trucf Cb9.4 Enucleation of the right eye. CJ Q1|4 Macroscopy: The eyeball measures 25 mm in diameter and the posterior optic nerve segment 5 mm. The piece has been fixed and included entirely. Su patm dis cryoau  Microscopy The histological examination reveals a cell proliferation with the histological features of a melanoma. This tumor is composed of fusiform cells (70%). The mitotic index is low. There is a mild pigmentation load. The tumor invades focally the 1/3 inner part of the sclera, without extrascleral extension. The tumor size is 20X15 mm. The ciliary body is free of tumor. The lesion is located at 1 mm of endo-ocular emergence of the optic nerve. The optic nerve on its entire course and the meningeal sheaths are free of tumor. The cut end of the optic nerve is also free of tumor. Conclusion: Uveal melanoma composed of fusiform cells (70%) Epithelioid cells : 30% Tumor size: 20 mm. Low mitotic index Tumor infiltration of the 1/3 inner part of the sclera without extrascleral extension. Ciliary body, optic nerve in its entire course and cut end free of tumor.
+
+--- Page 2 ---
+V4.00 TCGA Pathologic Diagnosis Discrepancy Form Instructions: The TCGA Pathologic Diagnosis Discrepancy Form should be completed when the pathologic diagnosis documented on the initial pathology report for a case submitted for TcGA is inconsistent with the diagnosis provided on the Case Quality Control Form completed for the submitted case. Tissue Source Site (TsS):  TSS Identifier: TSS Unique Patient Identifier:.- Completed By (Interviewer Name on OpenClinica). . Completed Date:.- Diagnosis Information. Data Element Entry Alternatives Working Instructions  Provide the diagnosis/ histologic subtype(s) documented on 30% epithelioid cells  Pathologic Diagnosis the initial pathology report for this case. If the histology for this case is mixed, provide all listed subtypes. Provided on Initial 70% spindle cells  Pathology Report Provide the histologic features selected on the TCGA Case Histologic features of 61-90% epithelioid cells Quality Control Form completed for this case. the sample provided for TCGA, as reflected 1-30% spindle cells  on the CQCF. Discrepancy between Pathology Report and Case Quality Control Form  Provide a reason describing why the diagnosis on the initial 3 Provide the reason for The section of the frozen sample used for sending  pathology report for this case is not consistent with the the discrepancy to TCGA corresponds to a section of the tumor diagnosis selected on the TCGA Case Quality Control Form.  between the pathology report and the TCGA  where the epithelioid part is predominant. Case Quality Control The percentages mentioned on the initial Form.  Pathology Report correspond to an average on.the whole embedded sections used for establish the Pathology Report. Name of TSS Reviewing  Provide the name of the pathologist who reviewed this case for TCGA. Pathologist or  Biorepository Director I acknowledge that the above information provided by my insttution is ct and has been quality controlled.  TSS Reviewing Pathologist or Biorepository Director Date I acknowiedge that the above information provided by my institution is true and correct and has been quality controlled. The Attending Pathologist or the Department Chairman has been informed or is aware of the above discrepancy in diagnoses. : Principal Investigator Signature Date
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diff --git a/output/text/ceb793a4-bcdc-4b1b-baad-a8c4cb019b63.txt b/output/text/ceb793a4-bcdc-4b1b-baad-a8c4cb019b63.txt
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index 0000000000000000000000000000000000000000..dbfb27fc04afe61d853f2660b1056a46597cbe8a
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+
+--- Page 1 ---
+UUID:CB5480FC-4BE1-478D-BEB5-39D74FD3F2E8 tcgA-V3-A9ZX-01A-PR Redac ted SURGICAL PATHOLOGY REPORT ***ADDITIONAL PROCEDURES PRESENT***S Patient Name: Specimen #: Patient ID #: Date of Procedure: DOB: Date of Receipt: Client: Date of Report: Location:  Physician(s): SPECIMEN SUBMITTED A: LEfT EYE FINAL DIAGNOSIS Left eye,.enucleation - Malignant ciliochoroidal melanoma, epithelioid and spindle cell type - See synoptic report for summary of key pathologic findings. TCD.0- SYNOPTIC REPORT OF KEY PATHOLOGIC FINDINGS RpnLlc ceLL'mmiyeol 87713 Left eye: Procedure: S.t... Culappiny Loelin % ey. Enucleation Specimen Size: 4Cdreyo-Cl98 For Enucleation Anteroposterior diameter: 20.8 mm ftJ H/aQ|14 Horizontal diameter: 23.8 mm Vertical diameter: 22.0 mm Length of optic nerve: 8.9 mm For Enucleation-Diameter of optic nerve 3.5 mm (Slide measurement) Specimen Laterality: Left Tumor Site (macroscopic examination/transillumination): Superotemporal quadrant of globe Tumor Location After Sectioning: Distance from anterior edge of tumor to limbus at cut edge: 1 mm Distance of posterior margin of tumor base from edge of optic disc: 5 mm Tumor Involvement of Other Ocular Structures:. Sclera Choroid Ciliary body Histologic Type: Mixed cell type Histopathologic Type:.  Mixed cell melanoma (>10% epithelioid cells and <90% spindle cells) Histologic Grade (pG): Page 1 of 3 Print Date:
+
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+Surgical Pathology Report (continued). pG2: Mixed cell melanoma Tumor Size After Sectioning: Base at cut edge: 11.5 mm Greatest height: 8.1 mm Tumor Location: Anterior margin between equator and iris. Scleral Involvement: Intrascleral Margins: No melanoma at margins Growth Pattern: Solid mass Primary Tumor (pT): Iris: Not Applicable Ciliary Body and Choroid: pT2b: Tumor size category 2 with ciliary body involvement Regional Lymph Nodes (pN): pNX: Regional lymph nodes cannot be assessed Distant Metastasis (pM): Not applicable Additional Pathologic Findings:. +Mitotic rate: 35 per 40 high power fields(Field Diameter=0.55mm) Extravascular matrix pattern (PAS stain):Present Degree of pigmentation +mild +Macrophages +few +Tumor infiltrating lymphocytes +many Retinal detachment Hemorrhage Other: Cataract ***Electronic Signature*** ADDITIONAL PROCEDURE(S) DNA Extraction Date Ordered: Date Reported: PENDING CLINICAL DATA CHOROIDAL MELANOMA GROSS DESCRIPTION A. Received fresh labeled is a left eye measuring 22.0 mm superoinferiorly, 20.8 mm anteroposteriorly, and 23.8 mm horizontally. The globe is round in shape. An 8.9 mm length of optic nerve is present. The cornea is surgically absent. The thin rim of remaining cornea is transparent and measures 8.9 mm superoinferiorly, and 11.4 mm Page 2 of 3 Print Date:
+
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+Surgical Pathology Report (continued) horizontally. The sclera is smooth and glistening. Transillumination of the globe does reveal a shadow extending from 9:00 to 12:00. The globe is opened in a superior inferior meridian fashion to reveal a red-brown firm mass. The mass measures 8.1 mm in height and 11.5 mm in basal diameter. The mass does appear to grossly involve the choroid, ciliary body, iris, and retina. The sclera and optic nerve appear uninvolved. A lens is present. The specimen is totally submitted as follows: A1 superior calotte, A2 pupil optic nerve section, A3 inferior calotte, A4 optic nerve shave.  margin. w 1]30114 ual/Synchron s (circle: QUAL Page 3 of 3 END OF REPORT Print Date:
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diff --git a/output/text/ceb7ca37-6fa9-4498-9880-cfdcc0a69894.txt b/output/text/ceb7ca37-6fa9-4498-9880-cfdcc0a69894.txt
new file mode 100644
index 0000000000000000000000000000000000000000..bd12aa7c191e50fc8f2ca7872cb35eddcec97241
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+Chist of Pathology Phone Fax 1 Specimen:d Received: Status: Spec Type: SURGICAL P Subm Dr: ERNATANESIACHCSES JcA-0- 3 LEFT BREAST CANCER INVASIVE Situ. breust, Nvs c50.9 /27/11 OPERATION PERFORMED DATE: Doctor (s) : PROCEDURE: STMPIE.MASTECTOMY/SENTINELNODE XA. LSHE REMOE A. LT BREAST 7:00 SUPERFICIAL MARGIN B. LT BREAST MASTECTOMYS c. LT SENTINEL NODE #1 D. LT SENTINEL NODE #2 UUID:AB083371-A2A8-4F57-8FBF-0DB2C91CEDDE E. LT BREAST ADDITIONAL TISSUE 12:00 TCGA-A2-A0YL-01A-PR F. RT SENTINEL NODE #1 Redacted G. RT SENTINEL NODE #2 H. RT BREAST TISSUE PART A RECEIVED LABELED LEFT BREAST 7 O'CLOCK SUPERFICIAL MARGIN INK MARKS NEW MARGIN, IS AN OVOID FLAT PORTION OF YELLOW FATTY TISSUE MEASURING 6 X 4 X O.9 CM IN GREATEST DIMENSIONS. INK IS FOUND ON ONE SIDE OF THE SPECIMEN. THIS IS RE-INKED WITH BLUE INK WITH A PERIMETER OF BLACK INK. THIS IS SECTIONED AND SUBMITTED ENTIRELY LABELED A1 THROUGH 6. PART B RECEIVED LABELED LEFT BREAST STITCH AT 12 O'CLOCK, IS A SIMPLE MASTECTOMY SPECIMEN MEASURING 16 X 16 X 5.2 CM.  THE NIPPLE IS UNREMARKABLE WITHIN A 9.5 X 4.8 CM SKIN ELLIPSE. BLUE DYE IS NOTED IN THE MID-SUPERIOR PORTION OF THE SPECIMEN. A SUTURE DENOTES 12 O'CLOCK. THE SUPERFICIAL ASPECT IS MARKED WITH BLUE INK, THE DEEP MARGIN WITH BLACK INK.   SECTIONING REVEALS THE CENTRAL 8Ot OF THE SPECIMEN TO CONSIST OF FIRM PINK-TAN TISSUE WITH SOME CYSTIC AREAS. THERE IS ILL-DEFINED INDURATION WITHIN THIS FIBROUS TISSUE AS WELL AS FOCAL NODULARITY. MOST INDURATED TISSUE MEASURES 9.0 CM FROM SUPERIOR TO INFERIOR, 9.0 CM THE FROM MEDIAL TO LATERAL AND UP TO 3.8 CM FROM SUPERFICIAL TO DEEP.  THIS IS IN THE CENTRAL PORTION OF THE BREAST. GROSSLY, THIS INVOLVES THE CENTRAL FOUR QUADRANTS OF THE SPECIMEN. THE CENTRAL LESIONAL AREA IS GREATER THAN 1 CM FROM THE SUPERIOR, INFERIOR, MEDIAL AND LATERAL MARGINS GROSSLY. SECTIONING THE CENTRAL FIBROUS TISSUE REVEALS A MOTTLED PINK TO GRAY-WHITE APPEARANCE. SECTIONS ARE SUBMITTED AS FOLLOWS: B1--NIPPLE, B2--UPPER OUTER QUADRANT, B3--UPPER INNER QUADRANT, B4--LOWER INNER QUADRANT, BS--LOWER OUTER QUADRANT. NOTE: B1 THROUGH B5 ARE MIRROR IMAGE TO PROTOCOL SECTIONS. B6--UPPER OUTER QUADRANT AND DEEP MARGIN, B7--EXTREME INFERIOR LESION WITH SUPERFICIAL MARGIN (7 O'CLOCK AREA). B8--EXTREME SUPERIOR LESION WITH 5 CM OF INTERVENING TISSUE BETWEEN THIS AND B7, B9--EXTREME MEDIAL ASPECT OF THE LESION, B1O--EXTREME LATERAL
+
+--- Page 2 ---
+Chief of Fathology. Phone ( Fax Specimen: Received: Status: Spec Type: SURGICAL P Subm Dr: GROSS DESCR TPTION (Continued) ASPECT OF THE LESION 9 CM FROM B9, B1I--SUBAREOLAR AREA, B12--UPPER OUTER QUADRANT, B13--UPPER INNER QUADRANT, B14--LOWER INNER QUADRANT, B15--LOWER OUTER QUADRANT, B16--QUESTION BIOPSY SITE CENTRAL BREAST, B17--QUESTION FIBROCYSTIC DISEASE UPPER INNER QUADRANT. PART C  RECEIVED LABELED LEFT SENTINEL NODE #1 HOT AND BLUE, IS YELLOW-RED FATTY TISSUE MEASURING 2.7 X 2.1 X 1.2 CM. FOCAL BLUE DYE IS NOTED.  SECTIONING REVEALS THIS TO BE A LARGELY FAT-REPLACED LYMPH NODE WITH FOCAL BLUE DISCOLORATION. IN THE ADJACENT TISSUE, THREE ADDITIONAL LYMPH NODES ARE IDENTIFIED MEASURING O.5 TO O.7 CM IN GREATEST DIMENSION. THE LARGEST GROSSLY FAT-REPLACED NODE IS SUBMITTED AS C1. THE REMAINING THREE NODES ARE SUBMITTED AS C2.S PART D RECEIVED LABELED  LEFT SENTINEL NODE #2 HOT AND BLUE, IS YELLOW FATTY TISSUE MEASURING 3 X 2.7 X 1.0 CM. SECTIONING REVEALS A 1.4 CM IN GREATEST DIAMETER GROSSLY UNREMARKABLE LYMPH NODE, SUBMITTED LABELED D. PART E RECEIVED LABELED LEFT BREAST ADDITIONAL 12 O'CLOCK MARGIN INK AT NEW MARGIN, IS AN IRREGULAR PORTION OF YELLOW-RED FATTY TISSUE MEASURING 11.5 X 5.3 X 1.0 CM. INK IS FOUND ON ONE SIDE OF THE SPECIMEN. THIS IS FURTHER MARKED WITH BLUE INK WITH A PERIMETER OF BLACK INK.  REPRESENTATIVE TISSUE IS SUBMITTED LABELED E1 THROUGH 10. APPROXIMATELY 7Ot OF THE SPECIMEN IS SUBMITTED.S PART F RECEIVED LABELED RIGHT SENTINEL NODE #1 HOT AND BLUE, IS AN OVOID PORTION OF YELLOW-BLUE TISSUE MEASURING 1.1 X O.5 X O.5 CM.  SECTIONING REVEALS THIS TO BE UNREMARKABLE NODAL TISSUE, SUBMITTED LABELED F. PART G  RECEIVED LABELED RIGHT SENTINEL NODE 2 BLUE AND HOT, IS YELLOW-RED FATTY TISSUE WITH BLUE DYE MEASURING O.8 X O.5 X 0.4 CM. THIS IS BISECTED REVEALING UNREMARKABLE NODAL TISSUE. THIS IS SUBMITTED LABELED G. PART H RECEIVED LABELED IS A SIMPLE MASTECTOMY SPECIMEN MEASURING 20.5 X 18 X 4.5 CM.  THE NIPPLE IS UNREMARKABLE WITHIN A 9.3 X 6.2 CM SKIN ELLIPSE. FOCAL BLUE DISCOLORATION IS NOTED IN THE 12 O'CLOCK AREA WHERE THERE IS AN ORIENTING SUTURE. THE SUPERFICIAL ASPECT IS MARKED WITH BLUE INK, THE DEEP WITH BLACK INK. SECTIONING REVEALS THE CENTRAL 85t OF THE SPECIMEN TO CONSIST OF PINK-TAN, FIRM FIBROUS TISSUE WITH MULTIPLE CYSTIC SPACES CONTAINING CLOUDY BROWN FLUID. NO DISTINCT MASSES ARE IDENTIFIED.  REPRESENTATIVE SECTIONS ARE SUBMITTED AS FOLLOWS: H1--NIPPLE, H2--CENTRAL DEEP MARGIN, H3 AND 4--UPPER INNER QUADRANT, H5 AND 6--UPPER OUTER QUADRANT, H7 AND 8--LOWER OUTER QUADRANT, H9 AND 10--LOWER INNER QUADRANT. NOTE THAT H4 IS THE EXTREME MEDIAL MARGIN.
+
+--- Page 3 ---
+Chist of Fathologyd Phone Tax Specimen: Received:d Status: Spec Type: SURGICAL P Subm Dr: PROCEDURES: 88307/8, IMMUNOPEROXIDAS/4, A BLK/6, B BLK/17, CBX X6/2, DBX X6, E BLK/10, FBX X6, GBX X6, H BLK/10 PART A LEFT BREAST, REEXCISION OF SUPERFICIAL 7 O'CLOCK MARGIN: BREAST TISSUE WITH NO EVIDENCE OF TUMOR AND CLEAR MARGIN. FATTY PART B  LEFT BREAST, SIMPLE MASTECTOMY: DIFFUSELY MULTIFOCAL AND MULTICENTRIC INTRALOBULAR_AND INFILTRATING +. LOBULAR CARCINOMA, NUCLEAR GRADE II, LOW MITOTIC INDEX AND TUBULE FORMATION 3, WITH TOTAL NOTTINGHAM SCORE OF 6. 2. THE INVASIVE TUMOR IS SEEN IN SECTIONS FROM EACH OF THE FOUR QUADRANTS ON 14 OF 17 BLOCKS EXAMINED, HAVING A MAXIMUM GROSS DIMENSION OF 9 CM. 3.  THE TUMOR IS GREATER THAN 1 CM FROM THE MARGINS OF EXCISION. 4.  LYMPHOVASCULAR INVASION IS IDENTIFIED. PART C LEFT AXILLA, SENTINEL LYMPH NODE: METASTATIC BREAST CARCINOMA IS IDENTIFIED ON H&E STEP SECTIONS AND CYTOKERATIN STAIN IN 3 LYMPH NODES,S THE LARGEST FOCUS OF WHICH MEASURES 5 MM. PART D LEFT AXILLA, SENTINEL LYMPH NODE BIOPSY #2: METASTATIC CARCINOMA CONSISTENT WITH BREAST PRIMARY IS MULTIFOCALLY IDENTIFIED IN THE LYMPHOID SINUSES ON H&E STEP SECTIONS AND CYTOKERATIN STAIN IN 1 LYMPH NODE. PART E LEFT BREAST, REEXCISION OF 12 O'CLOCK MARGIN: FATTY BREAST TISSUE WITH NO EVIDENCE OF TUMOR AND CLEAR MARGIN. PARTS F AND G RIGHT AXILLA, SENTINEL LYMPH NODE BIOPSIES 1 AND 2: NO EVIDENCE OF METASTATIC TUMOR ON H&E STEP SECTIONS OR CYTOKERATIN STAIN IN 2 LYMPH NODES EXAMINED. PART H  RIGHT BREAST, SIMPLE MASTECTOMY: FIBROCYSTIC CHANGES INCLUDING COLUMNAR CELL HYPERPLASIA WITH FOCAL AREA OF MILD EPITHELIAL ATYPIA,S APOCRINE METAPLASIA, MILD TO MODERATE USUAL DUCT HYPERPLASIA, DENSE FIBROUS STROMA AND MICROCYST FORMATION.
+
+--- Page 4 ---
+Chist of zathology Phone Fax Patient. Specimen: Received: Status: Spec Type: SURGICAL P Subm Dr: 1 Signed ) (prelim.) (signature on file)
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diff --git a/output/text/cecf0057-8274-4b7d-9d0f-ceb78654c0b2.txt b/output/text/cecf0057-8274-4b7d-9d0f-ceb78654c0b2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3ea9d25108b30e7619429338cb8d156962fe14bc
--- /dev/null
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+
+--- Page 1 ---
+*** Diagnosis / Diagnoses: *** 1.: Resectate of the colon or sigmoid colon with diverticulosis, with tumor-free oral and aboral resection margins and under inclusion of an ulcerated, moderately differentiated adenocarcinoma, with infiltration of the perimuscular fatty tissue and without regional lymph node metastases (G2, pT3 pN0 0/28 L0 V0 R0). 2.: Tubular colonic mucosal adenoma with slight dysplasia (synonym: low-grade intra epithelial neoplasia).
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diff --git a/output/text/cecfeff4-11a7-46f2-81e2-454228c253db.txt b/output/text/cecfeff4-11a7-46f2-81e2-454228c253db.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d810f18d7109e841bea1f1634338b9170f019f8e
--- /dev/null
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+
+--- Page 1 ---
+Carcin onia. lnfiltrating suct, NoS 8500|3 PATIENT hISTORy: S;te Code: breust, uIQ - C50.2 CHIEF COMPLAINT/ PRE-OP/ POST-OP DiAGNOSIS: Invasive ductal carcinoma in the left breast at 10 o'clock. Calcifications and atypia at 12 o'clock. C QCF . bruK, nv5 C50.9(Uppur mnv qusdrent) LMP DATE: Not listed. PROCEDURE: Left segmental mastectomy, sentinel lymph node biopsy, excisional biopsy.. SPECIFIC CLINICAL QUESTION: Not listed. OUTSIDE TISSUE DIAGNOSIS: No. UUID:01E8D241-C303-47FA-B484-B800D580B34C2 PRIOR MALIGNANCY: No. TCGA-BH-A18I-01A-PR  Redacted CHEMORADIATION THERAPY: No. QTHER DISEASES: No. FINAL DIAGNOSIS: Part 1: Left breast, g0 O'clock, segmental mastectomy - A. TWO fOci Of InVaSIve DucTal CArcinomA, NO SPeCIal Type. 8. NOTTINGhAm GRADE 2 (TUBULe fORmATION: 2, NUCLEAR PLEOmOrPhISm: 3, MITOTIC ACTIViTy: 2; Total Score: 7/9). C. THE DOMINANT mASS OF iNVASIVE CARCINOMA MEASURES 1.9 Cm iN LARGEST DIMENSION. D. THE SATELLiTE FOCUS MEASURES 0.6 CM AND IS PRESENT 0.5 CM AWAY FROM THE MAIN MASS. E.  Ductal Carcinoma in-Situ (dcis), nuclear Grade 2, Cribriform type. F. THE DCIS CONSTITUTES 10% Of thE TOTAL TUMOR VOLUME AND IS ADMIXED WITH INVASIVE COMPONENT. G.  NO LYMPHOVASCULAR SPACE INVASION IS NOTED. H. THE INVASIVE CARCINOMA (DOMINANT MASS) FOCALLY EXTENDS TO THE SUPERIOR MARGIN AND IS <0.1 Cm TO THE POSTERO-iNFERIOR MARGIN. 1. ThE SATeLLITE FOCUS OF INVASIVe CARCiNOMA IS 0.15 CM FROm THE POSTERIOR MARGIN. J. FLAt epithelial Atypia. K. CALCiFICATIONS ARE ASSOCIATED WITH INVASIVE CARCINOMA AND BENIGN BREAST PARENCHYMA. L. THE NON-NEOPLASTIC BREAST SHOWS FLORID DUCTAL HYPERPLASIA, COLUMNAR CELL CHANGE AND FIBROCYSTIC CHANGES. M. PREVIOUS BIOPSY SITE CHANGES. N.  THE INVASIVE TUMOR CELLS ARE POSiTIVE FOR ESTROGEN RECEPTOR (H- score 240) AND POSITIVE fOr PrOgESterONe REceptOr (H-score 240) AND nEgAtive fOr hER-2, AS PER PrevIOUS  PAtHOLOgy REPORt part 2: Left Breast, 12 O'clOck, biOpsy -- Criteria A. FLORID DUCTAL HYPERPLASIA. B.  COLUMNAR CELL CHANGES AND HYPERPLASIA. C. RADIAL SCAR.  FIBrOadenomatOid AnD FiBrocystic Changes. D. E.  NO Residual Atypia Seen. F.  PReVIOUS bIOPSY SITe Part 3: Left sentinel Lymph node #1, Biopsy -- A. One Lymph node, positive fOr metastatic tumor (1/1). The metastAtIC fOcus mEasUres 0.6 Cm in LARgest DimensiOn. C.  FOCAL EXTRACAPSULAR EXTENSION (<0.1 CM) IS IDENTIFIED. PaRt 4: LEft Sentinel Lymph nODE #2, bIOpSy - Two lymph nodes, negative for metastatic tumor (0/2). COMMENT: The invasive tumor nuclear grade is variable and ranges-from nuclear grade 2 to nuc!ear grade 3. The highest grade is taken into account for Nottingham scoring and grading. MICROSCOPIC: Microscopic examination substantiates the above diagnosis.. Antibody/Antigen Result E-cadherin Membranous reactivity in invasive tumor cells. P120 Membranous reactivity in invasive tumor cells. Utilizing formalin-fixed (8-96 hour range). paraffin embedded tissue, immunohistology is performed with the following selected antibodies and designated antibody clone(s). directed against the following antigenic target(s). with adequate positive and negative internal and external controls. Antibodies are optimized appropriate for fixation times. ANTIBODY CLONE TARGET ANTIGEN VENDOR E-cadherin 36 Ductal Carcinoma P120 98 Lobular carcinoma
+
+--- Page 2 ---
+CASE SYNOPSIS: SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST LAtEraLIty: Left Proceoure: Segmental LOCATION: Clock position:10.00 SIZE OF TUMOR:  Maximum dimension invasive component: 19 mm. MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: Yes TUMOR AGGREGATE SIZE: Sum of the sizes of multiple invasive tumors: 2.5 mm TUMOR TYPE (invasIve component): Ductal adenocarcinoma, NOS NOTTINGHAM SCORE: Nuclear grade: 3 Tubule formation: 2 Mitotic activity score: 2 Total Nottingham score: 7 Nottingham grade (1, 2, 3): 2 ANGIOLYMPHATIC INVASION:S No DERMAL LYMPHATIC INVASION:  Not applicable CALCIfICATION: Yes, benign zones Yes, mallgnant zones Tumor type, In sItu: Cribriform DCIS admixed with invasive carcinoma Percent of tumor occupied by in situ component: 10 % SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: Yes, foca! SURG MARGINS iNVOLVED by iN SITU COMPONENT: No LyMPH NODES POSITIVE: 1 LymPH NODES EXAMINED: 3 METHOD(S) OF LYMPH NODE EXAMINATION: H/E stain SENTINEL NODE METASTASIS: Yes SIZE OF NODAL METASTASES: Diarneter of largest lymph node metastasis: 6 mm. LyMPH NODe METASTASIS(-ES) WiTH EXTRACAPSULAR EXTeNSiOn: Yes, Maximum size is:0.75mm NON-NEOPLASTIC BREAST TISSUE: FCD t Stage, PathologIc: pT1c N StAge mOdIFIer: (sn) N Stage, pathologIc: pNX M STAGE: Not applicable Estrogen receptors: positive, H-score: 240 PROGESTERONE RECEPTORS: positive, H-score: 240 HER2/NEU: 1+ Comment: The tumor pN stage is at least pN1. Since the sentinel node is positive, a final N stage will be assigned after complete lymph node dissection.
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diff --git a/output/text/ced4917b-4d48-465d-a086-ad0922c4e504.txt b/output/text/ced4917b-4d48-465d-a086-ad0922c4e504.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2953cba229bf1bb29e3d7206dd551f696cc17d73
--- /dev/null
+++ b/output/text/ced4917b-4d48-465d-a086-ad0922c4e504.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+FINAL DIAGNOSIS: Part 1: breast. RIght, Segmental mastectomy -- A.  Inyasive Ductal Carcinoma. B.  nOttingham gRADe^1"(tuBuLe fOrmaTiOn- 2 , nucLEAr PLeOmORphISm - 2, mItOtIC ActIvIty - 1; total score: 5/9). C. TUmOr mEASURES 2 CM in LARgESt DimeNSIOn (GROSS). D. RESECTIOn mArgINS ARE nEgATIVE fOR inVaSiVE CARciNOmA, CLOSESt AnTERiOR AT 0.4 CM. E.  NO LYMPHOVASCULAR SPACE INVASION IS IDENTIFIED. F. PATHOLOGIC STAGE pT1c pN0 pMX. G. AtypICal DUctal hypErpLASIA. H. CALCIFICATIONS ARE ASSOCIATED WITH BENIGN BREAST PARENCHYMA. I. THE NON-NEOPLASTIC BREAST TISSUE SHOWS FIBROCYSTIC CHANGES WITH APOCRINE METAPLASIA, DUCTAL EpITHeLIAL hypERPLASIA, AND SCLErOSIng ADeNOSIS. J. PREVIOUS BIOPSY SITE CHANGES. THE INVASIVE TUMOR CELLS ARE POSITIVE FOR ESTROGEN, WEAKLY POSITIVE fOR PROGESTERONE K. AND NEGATIVE FOR HER-2/NEU (SCORE 0) AS PER PREVIOUS PATHOLOGY REPORT Part 2: Lymph nOde, Right axiLla, SentineL #1, excision -- ONE LYMPH NODE NEGATIVE FOR METASTATIC CARCINOMA (0/1). PART 3: Lymph nODE, RIght AXILLA, SEntinEL #2, EXCiSIOn - One Lymph nODe nEgATIVE fOR MEtAStaTiC CARcInOmA (0/1). CASE SYNOPSIS: 1cD-0-3 SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST Chrunomu, nifi1trsHrg ductl Nos 85of3 LATERALITY: Right Sin: braot, Nos C50.9 313/n h PrOceDure:  Segmental LOCATION: Upper outer quadrant SIZE OF TUMOR:  Maximum dimension invasive component: 2 cm MULTiCENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: No TUMOR TYPE (invasive component): Ductal adenocarcinoma, NOS NOTTINGHAM SCORE: Nuclear grade: 2 Tubule formation: 2 UUID:94CF5704-1BE7-4CCC-870E-FB8527AC47E8 Mitotic activity score: 1 TCGA-BH-A0h0-01A-Pr Redacted Total Nottingham score: 5 Nottingham grade (1, 2, 3): 1 ANGIOLYMPHATIC INVASION: No DERMAL LYMPHATIC INVASION:  Not applicable CALCIFICATION: Yes, benign zones SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No LYMPH NODES POSITIVE: Distance of invasive tumor to closest margin: 4 mm. LyMPH NODES EXAMINED: 0 METHOD(S) OF LYMPH NODE EXAMINATION: 2 SENTINEL NODE METASTASIS:  H/E stain NON-NEOPLASTIC BREAST TISSUE: ADH, FCD, Other: DEH, SA No T stage, pathologic: N Stage, PathologIC: pT1c M STAgE, PAThOLOgIC: pNO ESTROGEN RECEPTORS: pMX PROGESTERONE RECEPTORS: positive HER2/NEU:  positive zero or 1+
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diff --git a/output/text/ced9b02e-484b-4f85-b3f6-f48610d4d992.txt b/output/text/ced9b02e-484b-4f85-b3f6-f48610d4d992.txt
new file mode 100644
index 0000000000000000000000000000000000000000..69b79a3dd690684f4cb6002fb8fc32055bcabf14
--- /dev/null
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+
+--- Page 1 ---
+page 1 / 2 copy No. Date: Examination: Histopathological examination Examination No.: Internal invoice No. Value of diagnostic procedure Age: Gender: F Patient: XXX /es-0-3 Material: Total organ resection -st br 8523/3 Unit in charge: Central Operating Theatre Physician in charge:. CQLF: rontr' caunns, ductnl,P4pr1/ny_8503/2 Material collected on: : Material received on: Site: bust,nos c5o.9 Expected time of examination: 5 working days w 4/15 Clinical diagnosis:. Examination performed on: Macroscopic description: RagWwattstzed 21 x 17 x 5 cm removed without axillary tissues with a skin flap of 19 x 8.5 cm. Weight 700 g. Tumour sized 2.2 x 1,9 x 2.4 cm in the upper outer quadrant, located 2.1 cm from the upper boundary, 0.7 cm from the base and. 1.5 cm from the skin.. Microscopic description: Carcinoma mucinosum partim ductale invasivum - NHG2 (3 + 2 + 1/21 mitoses/10 HPF - visual area 0.55 mm). Foci of carcinoma ductale in situ Dcis found within the tumour (solid and cribrate type, with medium nuclear atypia and comedo necrosis 2% of the tumour). Lesions in situ of the type carcinoma intraductale mamillae.. Lesions in situ of the type mastopathia fibrosa et cystica in the glandular texture.. AXILLARY LYMPH NODES Sinus histiocytosis in tymphonodo (No I). Iest result  Final diagnosis to be given after .examination Compliance validated by: Examination performed on: Results of immunohistochemical examination:. Estrogen receptors found in over 75% neoplastic cell nuclei. Progesterone receptors found in over 75% neoplastic cell nuclei.. HER2 protein stained with by . . Negative reaction in invasive cancerous cells ( Score = 0) Compliance validated by: Examination performed on: UUID:D3EA3547-7E53-442E-A957-B2DD7EBAFBB9 Reda icted
+
+--- Page 2 ---
+Examination: Histopathological examination page 2 / 2 Examination No.: Patient: xXX Gender: F Examination performed on Histopathological Diagnosis: (including examination Carcinoma mucinosum partim ductale invasivum et ductale in situ mammae dextrae Jnvgstye mutinous andin part ductal! (coranans snd ductsh in situ canrelnorna of the right breast:y (NHG2, pT2, pN0/sn/) Compliance validated by: CONTACT YOUR DOCTOR WITH THIS REPORT!
+
+--- Page 3 ---
+TCGA Pathologic Diagnosis Discrepancy Form Instructions: The TcGA Pathologic Diagnosis Discrepancy Form should be completed when the pathologic diagnosis!.. documented on the mitial pathology.report for'a case submitted for TcGA isinconsistent with the diagnosis provided on the:. Case Quality Control Form completed for the submitted case:: .... Tissue Source Site (TSS):. TSS Identifier:  TSS Unique Patient Identifier:. Completed By (Interviewer Name : Completed Date: Diagnosis Information. :: ... . :..: B. Data Element Entry Alternatives Working Instructions  Provide the diagnosis/ histologic subtype(s) documented on  Pathologic Diagnosis the initial pathology report for this case. If the histology for Provided on Initial Pathology Report Histologic features of "Ductal partiaily papilary Provide the histologic features selected on the TCGA Case the sample provided Quality Control Form completed for this case. for TCGA, as reflected on the CQCF. Discrepancy between Pathology Report and Case Quality Control Forrn.:  Provide the reason for DRcweyQucyy daty  Provide a reason describing why the diagnosis on the initial.  the discrepancy  pathology report for this case is not consistent with the  between the pathology  diagnosis selected on the TCGA Case Quality Control Form. report and the TCGA due to Case Quality Control Form.  Name of Tss Reviewing Pathologist or e name of the pathologist who reviewed this cas for TCGA.  Biorepository Director 1 acknowledge that the above informatlon provided by my institution is true and correct and has been quality controlled. TSs Reviewing Pathologist or Biorepository Director. Date I acknowledge that the above information provided by my instibstion is true and correct and has been quality controlied. The Attending Pathologist or the Department Chairman has been informed or is aware of the above diserepancy In diagnoses.. Principal Investigator Signature Date
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diff --git a/output/text/ceea5b17-c1ce-460a-8939-328f9c248ae7.txt b/output/text/ceea5b17-c1ce-460a-8939-328f9c248ae7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5d640ebfbc13129a49ea9f0011065607cebc5ac3
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+
+--- Page 1 ---
+Icd-0-3 8500|3 12/8/10 lw S.re Couu. srsst nos c50.9 TSS UUID:AA4B6E2D-7503-4E51-BEA4-632CC994770A SPECIMENS:  TCGA-E2-A150-01A-PR Redacted A. WLE RIGHT BREAST NEEDLE LOC. B. ADDITIONAL MARGIN RIGHT BREAST C. WLE LEFT BREAST NEEDLE LOCALIZATION SPECIMEN(S): A. WLE RIGHT BREAST NEEDLE LOC. B. ADDITIONAL MARGIN RIGHT BREAST C. WLE LEFT BREAST NEEDLE LOCALIZATION GROSS DESCRIPTION: A. WLE RIGHT BREAST NEEDLE LOC. Received fresh labeled with the patient's identification and 'wLE right breast needle loc" is an oriented (short/1 clip- superior, long/2 clips-lateral, air knot-anterior) needle localized lumpectomy with radiograph. Ink code: Anterior-  yellow, posterior-black, medial-green, lateral-red, superior-blue, inferior-orange. The specimen is serially sectioned  from lateral to medial into 8 slices revealing a 2.4 x 1.9 x 1.6 cm firm tan stellate mass that is closest to the superior margin at 0.2 cm. Tissue is procured. Representatively submitted:. A1-A2: lateral margin, perpendicular resection A3: slice 2, anterior/superior A4: slice 2, posterior superior (mass) A5: slice 3, anterior/superior (mass) A6: slice 3, posterior superior (mass) A7: slice 3, anterior/inferior (mass) A8: slice 3, posterior inferior (mass) A9: slice 4, anterior/superior (mass) A10: slice 4, mid superior (mass) A11: slice 4, posterior superior (mass) A12: slice 4, anterior inferior (mass) A13: slice 4, posterior inferior (mass) A14: slice 5, anterior superior (mass) A15: slice 5, mid superior (mass) A16: slice 5, anterior inferior (mass) A17: slice 5, mid inferior (mass) A18: slice 6, anterior superior A19: slice 6, mid superior (mass) A20: slice 6, posterior superior A21: slice 6, mid inferior. A22: medial margin, perpendicular sections B. ADDITIONAL MARGIN RIGHT BREAST Received fresh labeled with the patient's identification and "additional margin right breast" is in a oriented (short- superior, long-lateral) 11 g. 0.2 x 3.4 x 1.1 cm fibrofatty tissue. Margins are inked black. Serial sectioning reveals no discrete lesions. Inked margin submitted entirely in cassettes B1-B7.. NOTE: specimen was received with only 1 suture. C. WLE LEFT BREAST NEEDLE LOCALIZATION Received fresh labeled with patient's identification and *WLE left breast needle localization' is an oriented (shor/1 clip-superior, long/2 clips-lateral, loop-anterior) 42 g, 4 x 4 x 3.5 cm needle localized lumpectomy with radiograph. Ink code: Anterior-yellow, posterior-black, medial-green, lateral-red, superior-blue, inferior-orange. Specimen is  serially sectioned from lateral to medial into 6 slices revealing a 2.4 x 1.9 x 1.8 cm firm tan stellate mass that is closest to the superior margin at 0.1 cm. Tissue is procured. Representatively submitted:. C1-C2: lateral margin, perpendicular sections C3: slice 2, anterior superior (mass) C4: slice 2, posterior superior (mass) C5: slice 2, anterior inferior (mass) C6: slice 2, posterior inferior (mass) C7: slice 3, mid superior (mass) C8: slice 3, posterior superior (mass) C9: slice 3, mid inferior (mass) C10: slice 3, posterior inferior (mass) C11: slice 4, anterior superior C12: slice 4, mid superior (mass) C13: slice 4, posterior superior C14: slice 5, anterior inferior
+
+--- Page 2 ---
+C15: slice 5, mid anterior C16: slice 5, anterior superior C17-C18: medial margin, perpendicular sections. DIAGNOSIS: A. BREAST, RIGHT, WIDE LOCAL EXCISION: - iNVASIVE DUCTAL CARCINOMA, SBR GRADE 2, MEASURING 2.4-CM  - INTERMEDIATE NUCLEAR GRADE, DUCTAL CARCINOMA IN SITU, SOLID AND CRIBRIFORM TYPES WITH CENTRAL NECROSIS AND MICROCALCIFICATIONS - INVASIVE TUMOR PRESENT WITHIN 1-MM FROM SUPERIOR/MEDIAL SURGICAL RESECTION MARGIN - LOBULAR CARCINOMA IN SITU  - BIOPSY SITE CHANGES WITH FIBROSIS - SEE SYNOPTIC REPORT AND SEE NOTE B. BREAST, RIGHT, ADDITIONAL SUPERIOR MARGIN, EXCISION: - INVASIVE DUCTAL CARCINOMA INVOLVES NEW INKED SURGICAL RESECTION MARGIN, SEE NOTE. C. BREAST. LEFT. WIDE LOCAL EXCISION - INVASIVE DUCTAL CARCINOMA, SBR GRADE 2, MEASURING 1.8-CM - SURGICAL RESECTION MARGIN NEGATIVE FOR TUMOR - LOBULAR CARCINOMA IN SITUE - BIOPSY SITE CHANGES WITH FIBROSIS - SEE SYNOPTIC REPORT. NOTE: Part B. was designated as superior by Dr. Therefore, invasive tumor is present at superior (part B) and within 1-mm from medial (part A) surgical resection margin.. E-cadherin is negative in LCIS component. SYNOPTIC REPORT - BREAST Specimen Type: Excision Needle Localization: Yes Laterality:  Right Invasive Tumor: Present Multifocality:  No WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Tumor size: 2.4cm Margins: Involved at superior  and within 1-mm from medial Extent:: focal Tubular Score: 2 Nuclear Grade: 2 Mitotic Score: 3  Modified Scarff Bloom Richardson Grade: 2 Necrosis: Absent Vascular/Lymphatic Invasion:  None identified Lobular neoplasia:  LCIS Lymph nodes: Non-sentinel lymph node DCIS present Margins uninvolved by DCIS DCIS Quantity:Estimate 10% DCIS Type: Solid Cribriform DCIS Location:Associated with invasive tumor Nuclear grade: Intermediate Necrosis: Present ER/PR/HER2 Results ER: Positive PR: Positive HER2: Negative by IHC Performed on Case: Pathological staging (pTN): pT 2 N x Pathological staging is based on the AJCC Cancer Staging Manuai, 7th Edition.
+
+--- Page 3 ---
+SYNOPTIC REPORT - BREAST Specimen Type: Excision Needle Localization: Yes Laterality: Left Invasive Tumof.- Present Multifocality:  No WHO CLASSIFICATION  Invasive ductal carcinoma, NOs 8500/3. Tumor size: 1.8cm Margins: Negative Distance from closest margin: 0.3cm superior Tubular Score: 2 Nuclear Grade: 2 Mitotic Score: 2 Modified Scarff Bloom Richardson Grade:. 2 Necrosis: Absent Vascular/Lymphatic Invasion: None identified Lobular neoplasia: LCIS Lymph nodes: No lymph node sampling. DCIS not present ER/PR/HER2 Results ER: Positive PR: Positive HER2: Negative by FISH Performed on Case: Pathological staging (pTN): pT 1c N x Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition CLINICAL HISTORY:  female found with left breast lump. She had bilateral mammogram done showing bilateral breast masses. Bilateral core needle biopsies done on  showed bilateral invasive ductal carcinoma., Bilateral  needle localization scheduled and no sentinel lymph nodes will'be taken as her axilta are clintcatly negative and it would not change post op management she will likely received radiation and endocrine therapy. PRE-OPERATIVE DIAGNOSIS: Bilateral invasive ductal carcinoma Right-ER/PR+, Her2/neu -, SBR grade 2 Left-ER/PR+, SBR grade 1 ADDENDUM: The right breast excision (Part A) measures 5x5x4.5-cm and weighs 63 gms. Microscopic/Diagnostic Dictation: Pathologist,. Final Review: Pathologist. Final: Pathologist, Addendum: Pathologist, r Addendum Final: Pathologist. AADi
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diff --git a/output/text/cf0107c1-a65d-4b48-8952-f432ccba680f.txt b/output/text/cf0107c1-a65d-4b48-8952-f432ccba680f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fa3b0cdeb756dd2f5185961d96fd30260865bd24
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@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+PALAOLOGIC DIRONOSTS: SPECTMEN LA3LEDLDFT KIDMEY RENAL C CARcnoMA 8.5 cm)Chromoptobe sypeFrhran 3rade 3. Iyaphovascular irvasior  not present. Renal artery,renal ven and ureter margins negaive for tumor. No ext.ersior irto perineplri tissue Soft tsnue rescctior.margir negat ive for turor. Cne l! Iympn nodenegative for turor. JCCT2NOM To simplecysts 3.C and 2.9 cm. The ron neopiastc kianey wl: be cvaaled by Rero Patho.ogy ad i inings wil b reported i an addenum. Immnoperoxidaser Tumor ce ls ssain for col oida iron. CHINICAL DATA: History: Nene glven. Cperation Let rephrecrony (laparoscopic) opcrat.ve Findings: None giver. l.ncalDiagnosis: Let tena mass. CEGAHSSE SLEMTED 1. Le.kidxey UROSS DESCRIPTTON: The npeciner in rece ved frest, in one par, laeed witl the pat ent's rarc unt numberard l.Lcft kidrey.and consist.s of ar 85s g lcft TACICH ncphreco spccimen .rc.drg kidreyin a (28.0 x12.) x6.7cm reler 1.s x 0.5 .in diareter cauter.zed.vin 1.8 crx 1.5 c in diare.er: rap.ed. rena aret2.5 x0.7 cm in d.ate.erscaped.No rera g.and is ldantified grossly. Ir tne mid kidrey ic a tan/gray, gram.er wel cirumibcd aolid/part.aly ecoic mss 8.bx 7.6. cm that  the dney capsule is 0.2 cn to ne rked nol cissue escstio margin
+
+--- Page 2 ---
+3.0 cm to tno artery, 0.9 cm i.o the veinand 3.8 cm to the rete resection The marg'n. he Lamo does ros gossly extend beyond the kidrey. rena. pels is distorted by ab.trg samor. Additionaly, there are cwo smal foc.ithin There are tw the renape.vs suspicous ter involvenens by tumor. shin le corcal cys13.C2.52.0 m and 2.9x2.52.5 cm in the in.erior poe. DArer are submit.cd for c.ectron n.croscopy, cytogeret.cs, and tre tissue banhing. Reprcsentatve sec.iono are nubr.tled for his.oloyy. Micro al:Jcter. ven renectior marg.ns 3 fxagy Miero 2 frac MCO T2 A3: A A6Tanor rarglr, :rag each, M.cr frg Miero 7: sccticn samor i adjacert parerchyma M .th renapelvis1 frag cach, Mcro A12 MicroA13Tamor rags with lesec on rargin Micro A14 runor with rorta 1 frag N.cro Aib: 3.0 c. cyst frag Micro A16: Korral kidney parerc frag Micro A7: 2.9 cm cys frag 5ha/her sigratre below, the serior plysician certiieo tnat tc/she peruonaly condcted a microscopc examinatior ("gross only exan  so slarcd o tle dencribed specireris; and rendered or confrmed the diagrosis(cs reiated thereto. RENAL PATHOLCGY EVALULATION CF NON -NROPLASTIC RENAL PARENCHYMA: LENKIDNRYNEPHRECTOMY: NILD IO MODERATE CHRONIC CHAXGES OF THE KIONEY PARENCHIYMA, NCLEDING: FOCAI CLOBAL CLOMERULOSCLEROSIS,MHLOPREDOMINANTY SJBCAPSJLAR, AND MOS LEKELY SECONCARY TO VASCULAR DISEASE (9I OF OLOMERULT; IBULAR ATNOPHY AND MTERSTITIAL FISROSISMTLD TO HODARAT 20OF PARENCIYMAAND
+
+--- Page 3 ---
+ARTERIAL AND ARTEROLAR SCLEROSS AND HYALINOSS MODERATE ISEENOT HOTE: he chroric charges seen in tne ron-reop.ast.c parenctyma axo racner ron spcci:.o ana do not poins co a spccifio dlsease ert.tty The Dreseeof g_oncruiwsh an cnaged cufs suggests that the foeal globaand segrertal g.ometiosc.crosis is rost likely secordar to strcturai ard functioral adaptatiors. Clonert.osclorosis is frequert!y the firn corsequcnce of such adaptatiors shas are brough: about by hemodyramic charges and c.oercla hypercrophy sclloving loss of funct.onig repnrons. Such.ocs of oitcr rnercsul o an rdeperdent pirayglomenlarlubo rterstiti. nost likcly in th's case, Vascu.ar diseave. Tte proteinra in patien w secondary focal and scgmcata glomeru.osc.ercs.n is most often slow.y progrensve. woualy aubreplrotic. and not accorpan.ed by sigrificart cdoma or hypoa.bwmirema. Because tne chronc charges scer here are most ikely cslt o fusct.oa adapsations o nepkron loss from ary glomerular, clar, ixterestial, vascular, or mass-repiacirg process.a s mi.ar degree o. Cronc damage would be expected in she con.ralateral kidney This paticnt, therefore, ray be at risk for persissent or progressive pro.eruria and renal Jrsurficiercy. ascular sclerouis witl parenchyma. atrcphy ard scleronis is often dcscribed nder the rslead.rg term of berign neptronleros s and ascribod ard dism ssed ns secordiary to hypert.ension to a prrary and adancei rlopnt.ty, or to age relatca degererasive change. Many cLhe erecognjzed forns of prinary vascula injury can result in such: changeg on biopsy ard are rore likely to represent che cause or she vasculax gclerogg and hypcrtcns on seer. in this patiert. Such vascar charyes are of.tcn the renclt of a hcalea cpisode cf s or Trp, pro-coagular staes finherited pro.coagu.ant states cn genetie Lhrorbophla or accuired artiphosplolipid tbody nynarome. et anoimmune disorders sclercderma, wnretieIisswe csordorsoverlap syndroneetc.roxe ljury afecsrg compocrtso lhc vascula wall (erocytosoxin antibody-mediated rascula injurythurora rejection.etc.l subntanco abuse wish arugs wtn racctia:
+
+--- Page 4 ---
+toxicity (cocaire, amphesamines,pseudoephecrine,e.c.).phyaicu factor irradiat cn, ctaus post bone marro transplantato)ard, poter.ialiy. metaboi diseases with an imporcat vascu.ar corporens lgout iaees The vacu ar involvemene within thc F.oney sevora of cnene condit.ons is wl-estabisiod and docunented roports in the :iLerat ure on hc furctiono and strtctura effects on t.ic k.drey n man c che irherced ara o acquired hrombophilc states And omg rotabelc dsorcers  ner ecant ad oftcn ired 10 anerdota. bservat:ons Hnd case repor.s.  k.aney parcnciyra has becr. revieved by Dr. coel M. Hendersor Rena. Patlologist PEERFENCES: Rernke Hio, Kiein rs. Fathoyenesls ard s.gnificance of nonprimary focal ard segmetai g.oeruionc.erosis.Am J kdney Dis 13443.56.989. MICROSCOPIS SESCPIPT:ON: Sections of formal n fixed,paraff embedded issueblock Als were ealul.ca asrg HEPAs,ores sver methenanircard AFog trichromoi stain. h samn.c onsiss of corex and rodlia. Therc are a4h glomerui prcsert, whih an 9.o aro cioba.y nclerosed mont. of the sc.erosed glomerl! are prowert in a m.bcapsulay discr.but.on. The rerain.ny gloncruli are sligrtly Cr. enlarged and slow focal ard rild expansion of the mesangia areas. PAS ard Jone s.iver mcthenamine stains, there are ro discerrible cralers or Several concours o tre glorcrlar capllary wali basement metbranes. csta tubues contain PAs-positive hyalire casts, with lumena distention ard wth calcideposits. The interstitam contars a mild rorcrucleal ce!1 irflamratory infiItrate in areas of tubular atrophy. Approxinately20 ofthe cort.enl parenchyma shows turu ar arophy ard interstitial fibrosis. ArLores xhib. a moderate degree ol primarly stbntmsl sclerosi. rocai sclrcsio ard hya incns o ther walis RcCT o399
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diff --git a/output/text/cf0fcd67-9409-478f-babe-a1dc94a2a2f1.txt b/output/text/cf0fcd67-9409-478f-babe-a1dc94a2a2f1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..24710f3e93f718b4bc2cf3814514116068f2706f
--- /dev/null
+++ b/output/text/cf0fcd67-9409-478f-babe-a1dc94a2a2f1.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UUID:979468F0-684A-4759-9CA2-78A1D1441BC2 TCGA-0L-A66P-01A-PR Redacted Sample LcD O-3 sitiststirg dlctNsS I ssa0|3 Surgical Pathology Report W s/16/13 FINAL PATHOLOGIC DIAGNOSIS A. Right axillary sentinel node #1, biopsy: - One lymph node, negative for metastatic carcinoma (0/1). (H&E and cytokeratin AE1/AE3) B. Right axillary sentinel node #2, biopsy:  - One lymph node, negative for metastatic carcinoma (0/1). (H&E and cytokeratin AE1/AE3) C. Superior mastectomy flap, excision: - Benign fibroadipose tissue with focal fat necrosis.. D. Right breast, simple mastectomy: - Two foci of invasive ductal carcinoma, SBR Grade II, see breast pathologic parameter. - Ductal carcinoma in-situ, intermediate nuclear grade, solid and apocrine types. - Microscopic focus of atypical ductal hyperplasia. - Previous biopsy sites identified. - Margins of excision are negative for invasive and in-situ carcinoma. - Intraductal papilloma (9 mm) with extensive hyalinization, see comment. - Hyalinized 6 mm nodule with osseous metaplasia.. - Columnar cell change. - Fibroadenomatous changes. - Apocrine metaplasia. - Sclerosing adenosis.. - Duct ectasia. E. Inferior flap, right breast excision: - Benign fibroadipose tissue with microscopic focus of breast parenchyma, distant from the new true margin. F. Medial flap, right breast excision: - Benign fibroadipose tissue. Breast Pathologic Parameters 1a. Invasive carcinoma: (1 o'clock lesion) A. Gross measurement: 2.1 x 1.9 cm B. Composite histologic (modified SBR) grade: II - Architecture: 3
+
+--- Page 2 ---
+- Nuclear grade: 2 - Mitotic rate: 1 C. Associated intraductal carcinoma in situ (DCIS): - Within main mass (forming less than 5% of tumor volume) 1b. Invasive carcinoma (12 o'clock lesion): 0.9 x 0.8 cm Composite histologic (modified SBR) grade II - Architecture: 3 - Nuclear grade: 2 - Mitotic rate: 1 Associated intraductal carcinoma in situ (DCIS): None. 2. Intraductal carcinoma: A. Microscopic measurement: Admixed with 1 o'clock lesion B. Type: Solid, Apocrine C. Nuclear grade: Intermediate D. Associated features: None 3. Excisional biopsy margins: Free of tumor. - DCIS more than 10 mm from anterior-superior (closest) margin - Invasive carcinoma more than 5 mm from anterior-superior (closest) margin 4. Blood vessel and lymphatic invasion: Suspicious. 5. Nipple: unremarkable 6. Skin: uninvolved. 7. Skeletal muscle: absent 8. Axillary lymph nodes: Negative (0/2) 9. Special studies (ER, PR repeated on mastectomy): 1 o'clock lesion - ER: No expression, 0% of invasive tumor nuclei - PR: No expression, 0% of invasive tumor nuclei - HER2 antigen (FISH) (biopsy Not amplified (ratio: 1.14) - Ki-67 (Performed on previous biopsy. : 35% Special studies (ER, PR repeated on mastectomy): 12 o'clock lesion. - ER: No expression, 0% of invasive tumor nuclei - PR: No expression, 0% of invasive tumor nuclei - HER2 antigen (FISH)(biopsy : Not amplified (ratio: 1.13) - Ki-67 (Performed on previous biopsy. ): 30% 10. pTNM (AJCC, 7th edition, 2010): pT2(m), N0(sn), MX Effective this Checklist utilizes the 7th edition TNM staging system for breast of the American Joint Committee on Cancer (AJCC) and the. International Union Against Cancer (UICC). Clinical History: The patient is a  year-old female with multicentric right breast invasive
+
+--- Page 3 ---
+ductal carcinoma undergoing simple mastectomy and sentinel node biopsies.  mammogram showed a hypoechoic mass at 1:00 in the right breast, 4 cm from the nipple, measuring 20 mm in maximum diameter. A smaller round hypoechoic mass measuring 8 mm in maximum diameter was additionally identified at 12:00 in the right breast, 4 cm from the nipple. Clips wereplaced in the. central aspect of both lesions. Comment D. Immunohistochemical stains for cytokeratin 5/14 were performed on block D7 and support intraductal hyperplasia, usual type. Immunohistochemical stains for p63 and mycin heavy chain were performed on D10 and support an intraductal papilloma. All immunohistochemical controls were appropriate. Specimens Received: A: Right axillary sentinal node #1 B: Right axillary sentinal ' node #2 C: Superior mastectomy flap D: Right breast E: Inferior flap right breast F: Medial flap right breast Gross Description: The specimens are received in six containers each labeled with the patient's name and medical record number. A. The first container is additionally identified as, 'right axillary sentinel node #1'. Received fresh for intraoperative consultation is a portion of rubbery yellow-tan tissue measuring 2.5 x 2.3 x 0.8 cm. The specimen is bisected and. entirely frozen, and the frozen section diagnosis by Dr.  is 'no tumor'. The frozen section remnants are entirely submitted in A1 FS and A2 FS. B. The second container is additionally identified as, 'right axillary sentinel node #2'. Received fresh for intraoperative consultation is a portion of yellow-tan and blue-tinged tissue measuring 1.5 x 1.0 x 0.8 cm. The specimen is bisected and entirely frozen, and the frozen section diagnosis by Dr. is 'no tumor'. The frozen section remnant is entirely submitted in B1 FS.
+
+--- Page 4 ---
+C. The third container is additionally identified as, 'superior mastectomy flap'. Received fresh and placed in formalin is a 26.5 gram, 10.3 x 4 x 0.9 cm portion of lobulated yellow fibroadipose tissue. There is a stitch on one aspect. of the specimen designating the final anterior margin. The aspect of the specimen with the stitch is inked black. The specimen is serially sectioned to reveal grossly unremarkable lobulated yellow fibroadipose tissue. Representative sections are submitted in C1-C5. D. The fourth container is additionally identified as, 'right breast'.. Received fresh and placed in formalin is a 593.6 g simple mastectomy specimen The specimen is oriented with a double short suture designating the superior aspect and a double long suture designating the lateral aspect. The breast measures 24.5 cm from medial to lateral, 18 cm from superior to inferior, and 3.5 cm from anterior to posterior. On the anterior surface is a 21.5 x 13.5 cm brown ellipse of skin with a 5.5 x 3.8 cm areola and a 1.2 x 1.1 x 0.5 cm raised nipple. The nipple-areolar complex reveals no evidence of ulceration or retraction. The specimen is inked as follows:. anterior-superior - blue; anterior-inferior - green;. posterior - black.. The specimen is serially sectioned from medial to lateral into 20 slices (slice 1 - medial, nipple in slice 10) to reveal a well-circumscribed lobulated tan mass measuring 2.1 x 1.9 x 1.5 cm in the superior aspect of slices 7 and 8. The mass is 1.3 cm from the posterior (black) margin, 1.3 cm from the anterior superior (blue) margin, and 0.9 cm from the anterior skin. In slice 8, 1.8 cm superior to the first mass, is a 0.9 x 0.8 x 0.8 cm rubbery mass that is located 1 cm from the posterior (black) margin and 0.8 cm from the anterior superior (blue) margin. A clip is identified in slice 8 within the second mass. There are 2 additional nodular areas in the breast. The first measures 0.9 x 0.8 x 0.7 cm and is located in the inferior aspect of slice 11, 1.6 cm from the posterior (black) margin. The second nodular area measures 0.5 x 0.4 x 0.4 cm and is found in the inferior aspect of slice 15, 1 cm from the posterior (black) margin. The remainder of the specimen consists of approximately 25% dense gray-white fibrous breast parenchyma and 75% lobulatedyellow adipose tissue. No additional masses or nodules are grossly identified.. Block summary: D1: mass #1, slice 7 D2: mass #1, slice 7, including deep margin. D3: mass #1, slice 8, including closest to anterior superior margin. D4: masses #1 and #2, slice 8 D5-D6: mass #2, slice 8, including closest to anterior superior and deep margins (submitted in tandem) D7: medial to mass #1, slice 6 D8: inferior to mass #1, slice 8
+
+--- Page 5 ---
+D9: lateral to masses #1 and #2, slice 9 D10: nodular area #1, slice 11 D11: breast parenchyma between nodular areas #1 and #2, slice 13 D12: nodular area #2, slice 15 D13: lateral to nodular area #2, slice 16 D14: upper-outer quadrant slice 14 D15: lower-outer quadrant slice 14 D16: upper-inner quadrant slice 4 D17: lower-inner quadrant slice 5 D18: nipple D19: skin, slice 8 E. The fifth container is additionally identified as, 'inferior flap right breast stitch marks final anterior margin'. Received fresh and placed in formalin is a 6.5 g, 4.7 x 3.2 x 0.6 cm portion of lobulated yellow fibroadipose tissue. On one aspect of the specimen is a stitch designating the final anterior margin. The aspect of the specimen with the stitch is inked black. The specimen is serially sectioned to reveal grossly unremarkable lobulated yellow fibroadipose tissue. Representative sections are submitted in E1-E5. F. The sixth container is additionally identified as, 'medial flap right breast stitch marks final anterior margin'. Received fresh and placed in formalin is a 3.5 g, 4.7 x 1.4 x 0.7 cm portion of lobulated yellow fibroadipose tissue. There is a stitch on one aspect of the specimen designating the final anterior margin The aspect of the specimen with the stitch is inked black. The specimen is serially sectioned to reveal grossly unremarkable lobulated yellow fibroadipose tissue. The specimen is entirely submitted in F1-F4. Tissue fixed for at least 6 hours in 10% NBF and no more than 72 hours.  MD, PhD Intraoperative Consult Diagnosis: A1 FS and A2 FS: 'no tumor, by Dr. B1 FS: 'no tumor', by Dr.. ew 4/2/13 imary Tumor Site Discrepdl HIPAA Discrepancy
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diff --git a/output/text/cf173189-3972-49e7-a6e9-3c500289e6d6.txt b/output/text/cf173189-3972-49e7-a6e9-3c500289e6d6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4d13e4f3601e2f8292d9150fe3d967f2b5676075
--- /dev/null
+++ b/output/text/cf173189-3972-49e7-a6e9-3c500289e6d6.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+icd.0-3 8500/3 PAtIent hIstOry: * DATE of LMP: Srh cod: breuot, N0s c50.9 DATE OF LAST DELIVERY: PRE-OP DIAGNOSIS: CA L BREAST .POST-OP DIAGNOSIS: SAME  OPERATIVE PROCEDURE: LEF"T MODIFIED RADICAL MASTECTOMY CLINICAL HISTORY: * MATERIAL SUBMITTED: LEFT (MOD) RADICAL MASTECTOMY, PROCUREMENT BY SURGICAL PROCEDURE Lt breast & axillary content FINAL DIAGNOSIS: FINAL DIAGNOSIS: BREAST AND. AXILLA, LESD, MODIFIED RADICAL MASTECTOMY:S INFILTRATING DUCIAL CARCINOMA S"A2-A7").4.5 BY 4.5 BX 3.5 C4, NOTTINGHAM 6/9 (TUBULES 3, NUCLEI 3. MITOSIS I) , WITH LYMPHOVASCULAR PERMRATION, INVOLVING THE DEEP DERMIS - DUCTAL CARCINOMA IN-SITU, SOLID TYPE, NUCLEAR GRADE 2, LESS THAN 1  MARGINS OF RESECTION ARE FREE OF TUSOR  NIPPLE FREE OF TUMOR TWO OF TWENTY-SIX (2/26) LEFT AXILLARY LYMPH NODES INVOLVED WITH TUMOR, LARGEST LYMPH NODE 2.3 CM ISS REPLACED BY TUMOR  NOTe: ER/PR immunoperoxidase assay and Her-2/Neu testing was porformed on block "A6". Cross refer ESTROGEN/PROGESTERONE AND HER-2/NEU REPORTS Using appropriate positive and negative controls, the test fox the presence of these hormone receptor. protains is performed by the immunoperoxidase method. and reported according to the. On adjuvant therapy for breast cancer, of consensus statement A positive ER or PR tumc. snows any nuclear. immunostaining, and is semiquantitated as indicated Result Semiquantitative Statement ER positive Percant cells staining as: (0- 0t 1+ 10t; 2+ 104; 3+ 80s) PR positive Percent cells staining as: (0- 0t; 1+ 04; 2+ 10t; 3+ 90t) *****++************************* HER-2/NEU - DAKO HERCEPTEST: A FAINT/BARELY PERCEPTIBLE MEMBRANE STAINING IS DETECTED IN MORE THAN 1O% OF THE TUDMOR CELLS. THE CELLS ARE ONLY STAINED IN PART OF THBIR MEMBRANE. _HER-2/NEU IS INTERPRETED AS NEGATIVE (SCORE 1+). NOTE: The Her-2/NeU and estrogen assays xere performad with FDA approved. xeceptor immunoperoxidase test used in this case has been developed and the performance characteristics. methods. The progesterone determined by the Departmant of Pathology at. They have not been cleared or approved by the U.s. Food and Drug Administration. UUID:60E8A9CF-3E2D-4E36-947D-448BA27C6561 TCGA-BH-A18N-01A-PR Redactedd
\ No newline at end of file
diff --git a/output/text/cf2c2a0b-4514-46a0-8768-30485eac9262.txt b/output/text/cf2c2a0b-4514-46a0-8768-30485eac9262.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c045e24087f0928decb12578922cf1d874edfc82
--- /dev/null
+++ b/output/text/cf2c2a0b-4514-46a0-8768-30485eac9262.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+ic-0-3 (rubusohaule) corcin onn,nfiHnsHvg kbrJ mixd nf ctw fyps 8524/3 s: 324 J Puth .Sits &di: breast, urpw ontn qusiunt TSS c 50.4 cQcF : srust,N0s C50.9 Tss: SPECIMENS: A. SENTINEL LYMPH NODE #1 RIGHT BREAST B. SENTINEL LYMPH NODE #2 RIGHT BREAST C. RIGHT BREAST D. SENTINEL LYMPH NODE #1 LEFT AXILLA E. SENTINEL LYMPH NODE #2 LEFT AXILLA F. LEFT BREAST SPECIMEN(S): A. SENTINEL LYMPH NODE #1 RIGHT BREAST B. SENTINEL LYMPH NODE #2 RIGHT BREAST C. RIGHT BREAST D. SENTINEL LYMPH NODE #1 LEFT AXILLA E. SENTINEL LYMPH NODE #2 LEFT AXILLA F. LEFT BREAST GROSS DESCRIPTION:S A. SENTINEL LYMPH NODE #1 RIGHT BREAST Received fresh are three tan pink lymph nodes all 1cm in greatest dimension. Three touch preps are taken. A1: one lymph node A2: one lymph node A3: one lymph node B. SENTINEL LYMPH NODE #2 RIGHT BREAST Received fresh is a tan pink lymph node 2 x 0.7 x 0.5 cm. The specimen is sectioned. A touch prep is taken. Toto B1. C. RIGHT BREAST Received fresh labeled with the patient's identification and designated *right breast" is a 110 g, 13 x 10 x 3.5 cm, oriented (suture in axilla), mastectomy with pink-tan 10.5 x 5.4 cm skin ellipse with 3.2 cm linear scar and everted 0.8 cm diameter nippie. Ink code: Posterior-black, anterior/superior-blue, anterior/inferior-orange. The specimen is serially sectioned from lateral to medial into 9 slices revealing a hemorrhagic firm biopsy cavity, 2.5 x 2 x 1.6 cm (slices 5-6) at 12:00, 0.1 cm from the deep margin and 0.2 cm from anterior (superior). Located adjacent and superior to the biopsy cavity (12:00, slices 5- 6) is an 1.7 x 1.2 x 0.8 cm ill-defined firm lesion that is 0.1 cm from the anterior margin and 0.3 cm from. the deep margin. Tissue is procured. Representatively submitted: C1-C2: Nipple C3: Skin C4-C5: Representative sections, upper outer quadrant C6: Slice 5, 12 o'clock, lesion C7-C9: Slice 5, biopsy cavity, 12 o'clock C10: Slice 6, lesion, 12 o'clock UUID:817D4725-01FE-4148-A8FC-3431F28D5CD8 TCGA-E2-A1BC-01A-PR C11-C13: Slice 6, biopsy cavity, 12 o'clock Redacted C14: Representative section, upper inner quadrant, slice 7 C15: Representative section, lower inner quadrant, slice 7 C16: Representative section, lower outer quadrant, slice 3 C17: Possible lymph nodes D. SENTINEL LYMPH NODE #1 LEFT AXILLA Received fresh are two tan pink lymph nodes 1.2cm and 0.4cm in greatest dimension. Two touch preps are taken. D1: one lymph node D2: one lymph node E. SENTINEL LYMPH NODE #2 LEFT AXILLA  Received fresh are two tan pink lymph nodes 2cm and 1cm in greatest dimension. Two touch preps are. taken. E1: one lymph node E2: one lymph node F. LEFT BREAST Received fresh labeled with the patient's identification and "left breast" is a 96g, 15 x 11 x 2cm oriented. (stitch in axilla) simple mastectomy with attached 11 x 4cm tan pink skin ellipse and 0.6cm everted nipple. The skin surface is remarkable for a well healed subareolar scar 1.8cm, 2cm inferior to the
+
+--- Page 2 ---
+TSs nipple in the LIQ-LC. ink code: anterior-superior: blue, anterior-inferior: orange, posterior-black. The specimen is serially sectioned from medial to lateral into 9 slices with nipple in slice 4, revealing a 1.6 x 1.1 x 1cm tan white firm ill defined mass, 0.3cm from the anterior-inferior margin and 0.5cm from the deep margin corresponding to the scar on the skin surface in the LC of slice 4. Representatively submitted: F1: nipple slice 4 F2: UIQ slice 2 F3: LiQ with scar slice 2 F4: UIQ slice 3 F5: LIQ slice 3 F6: UC slice 4 F7: LC anterior margin slice 4. F8-F9: mass with deep margin slice 4 F10-F11: LOQ slice 5 F12: UOQ slice 5 F13: LOQ slice 6 F14: UOQ slice 6 F15: UOQ slice 7 DIAGNOSIS: A. SENTINEL LYMPH NODE 1, RIGHT AXILLA, BIOPSY:  - THREE LYMPH NODES, NO TUMOR SEEN (0/3). B. SENTINEL LYMPH NODE 2, RIGHT AXILLA, BIOPSY: - ONE LYMPH NODE, NO TUMOR SEEN (0/1). C. breast, right, mastectomy: - INVASIVE TUBULOLOBULAR CARCINOMA, SBR GRADE 1. - TUMOR MEASURES 1.1 CM: - TUMOR INVOLVES THE SKELETAL MUSCLE. - TUMOR IS PRESENT AT THE ANTERiOR MARGIN AND iS WITHIN 0.1 CM OF THE DEEP MARGIN AT ~ 12:00. - PREVIOUS BIOPSY SITE CHANGES PRESENT. - SKIN AND NIPPLE, NO TUMOR SEEN.E NOTE: The tumor measured 1.8 cm in the previous excision. D. SENTINEL LYMPH NODE 1, LEFT AXILLA, BIOPSY: - TWO LYMPH NODES, NO TUMOR SEEN (0/2). E. SENTiNeL LYmph NODE 2, LEft AXilLA, BIOPSy: - TWO LYMPH NODES, NO TUMOR SEEN (O/2). F. breast, Left, mastectomy: - INVASIVE TUBULOLOBULAR CARCINOMA, SBR GRADE 1.E - TUMOR MEASURES 0.9 CM. - TUMOR IS WITHIN MICRONS OF THE ANTERIOR MARGIN ANDE IS 0.2 CM FROM THE DEEP MARGIN IN THE LOWER CENTRAL AREA. - PREVIOUS BIOPSY SITE CHANGES PRESENT. - SKIN AND NIPPLE, NO TUMOR SEEN. - ONE INTRAMAMMARY LYMPH NODE, NO TUMOR SEEN (0/1).E SYNOPTIC REPORT - BREAST Specimens Involved Specimens: A: SENTINEL LYMPH NODE #1 RIGHT BREAST B: SENTINEL LYMPH NODE #2 RIGHT BREAST C: RIGHT BREAST Specimen Type: Mastectomy
+
+--- Page 3 ---
+TSS Needle Localization: No Laterality: Right Invasive Tumor: Present Multifocality: No WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Tumor size: 1.8cm Tumor Site: , 12:00) Margins: tnvolved at anterior Extent:: 0.2 cm Tubular Score: 2 Nuclear Grade: 1 Mitotic Score: Modified Scarff Bloom Richardson Grade: Necrosis: Absent Vascular/Lymphatic Invasion:None identified Lobular neoplasia: None Lymph nodes: Sentinel lymph node. Lymph node status: Negative 0/4 DCIS not present ER/PR/HER2 Results ER: Positive PR: Positive HER2: Negative by IHC Pathological staging (pTN): pT 1c N 0 Pathoiogical staging is based on the AJCC Cancer Staging Manual, 7th Edition SYNOPTIC REPORT - BREAST Specimens involved Specimens: D: SENTINEL LYMPH NODE #1 LEFT AXILLA E: SENTINEL LYMPH NODE #2 LEFT AXILLA F: LEFT BREAST Specimen Type: Mastectomy Needle Localization: No Laterality: Left Invasive Tumor: Present Multifocality: No WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Tumor size:1.5cm Tumor Site: lower central Margins: Negative Tubular Score: 2 Nuclear Grade: Mitotic Score: 1 Modified Scarff Bloom Richardson Grade: Necrosis: Absent Vascular/Lymphatic Invasion:  None identified Lobular neoplasia: None Lymph nodes:  Sentinel lymph node Non-sentinel lymph node Lymph node status: Negative 0/5 DCIS not present ER/PR/HER2 Results
+
+--- Page 4 ---
+Tss: ER: Positive PR: Positive HER2: Negative by FISH Pathological staging (pTN): pT 1c N 0 Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition CLINICAL HISTORY:  Bilateral invasive breast cancer with prior surgical excisions PRE-OPERATIVE DIAGNOSIS: Bilateral breast cancer INTRAOPERATIVE CONSULTATION: TPA-TPB: SLN #1-#2-Right axilla: Negative for tumor. TPD-TPE: SLN #1-#2-Left axilla: Negative for tumor. Diagnoses called to Dr by Dr. Gross Dictation.. . Microscopic/Diagnostic Dictation:., Pathologist. Final Review: Pathologist. Final: Pathologist,
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diff --git a/output/text/cf61cc96-756a-43ec-9bd2-a8f27b728eda.txt b/output/text/cf61cc96-756a-43ec-9bd2-a8f27b728eda.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4ecfd7411b120e6c459e7f68620857526292a17c
--- /dev/null
+++ b/output/text/cf61cc96-756a-43ec-9bd2-a8f27b728eda.txt
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+
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+Surgical Pathology Report Name: Case #: DOB: Collected: Gender: F Received: MRN: Reported: Location: Copy To: Physician: Pathologic Interpretation: 1C0-0-3 A. Lymph node, sentinel lymph node, TP: No carcinoma seen in one lymph node (0/1). Carciona,nfiltrtwg olucta! nos 85o93 Keratin immunostains is pending. Sih: brenst, nsos C50.9 H{e/) 8. Lymph node, sentinel lymph node, TP: No carcinoma seen in one lymph node (0/1). UUID:F282122D-C129-4A8B-9A49-78D5267C37CA Keratin immunostains is pending. TCGA-EW-A136-01A-PR Redacted C. Lymph node, sentinel lymph node, TP: No carcinoma seen in one lymph node (0/1). Keratin immunostains is pending D. Right breast mass, 1 short stitch superior, 1 long stitch lateral:. Infiltrating. poorly differentiated ductal carcinoma, (high nuclear grade), 1.7 cm in greatest dimension.. The tumor cells are positive for ER and PR and they are negative for HER by immunohistochemestry. HER-2 CISH is pending.. See tumor summary E. Additional medial nodule, FS:  Mammary parenchyma with stromal fibrosis and associated calcifications. Surgical pathology c.ncer caes tumor summary Specimen Type: Partiai breast Procedure: Excision with out wire-guided localization Lymph Node Sampling: Sentinel lymph node. Specimen integrity: Single intact specimen (margins can be evaluated). Specimen size: Greatest dimension 5.8 cm/additional dimension; 538 x 2.5 cm. Latorallty: Right. Tumor Site: Not specify Tumor Size: Greatest dinension of focus of invasive 1.7 cm; additional dimension 1.6 x 1.6 cm. Tumor focality: single focus of invasive carcinoma. Macroscopic and microscopic oxtent of tumor: -Skin is not present -Skeletal muscle is not present Ductal carcinoma in situ: Ductal cell carcinoma in situ is present Size extent of (DCis): Numbers of blocks with (DCiS)_1 / Numbers of blocks evaluated  Archltectural Patterns: cribriform/solid Nuclear grade: Grade III Necrosis: Present, central expansive comedo Lobular Carcinoma: Not identified. Histologic Type: Invasive ductal carcinoma (no special type or not otherwise specified). Histologic Grade:Nottingham Histologic Score: 3 ( 3+3+2=8) Glandular/Tubular formation: Score 3 Nuclear Pleomorphism: Score 3 Mitotic Count: Score 2 Margins: Margins uninvolved by Invasive carcinoma. Distance from closest margin: 1 mm (Anterior) Distance from superior margin> 5 mm/ Distance from inferior margin 5 mm/ Distance from anterior margin  mm/. Distance from posterior margin>7mm/Distance from medial margin>5 mm/ Distance from lateral margin>5 mm Margins unInvolved by (DCIS) Distance from closest margin: 5 mm (Antenor)
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+SURGICAL PATHOL Report Distance from closest margin 5_mm// Distance from superior margin> 5 mm/ Distance from inferior margin 5 mm/ Distance from anteror margin 5 mm/ Distance from posterior margin>7mm/Distance from medial margin>5 mm/ Distance from lateral margin>5 mm. Lymph vascular inygsion: Present Dermal lymph-vascular invasion: No skin present. Lymph nodes:  Number of sentinel lymph nodes examined 3.  Number of lymph nodes with macrometastases (>0.2 mm and  200 cells) 0 Method of evaluation of sentine! lymph nodes: Hematoxylin and eosin (H&E), one leveVimmunohistochemistry pending Pathologic Staging: Primary Tumor: pT1c.d Reglonal Iymph nodes: pNO Distant Metastasis: No applicable Estrogen Receptor: Pending Progesterone Receptor: Pending HER2 IHC and CISH: Pending Preliminary Dx: AJCC pTc1 No (sn) MX (FInai AJCC pending ovaluatlon of keratin immunosatin on sentineltymph nodes). ***Electronically Signed Out By*+ NOTE: Some immunohstochermicsl sntbodies are anaiyte speciic reagents (AsRs) validated by our iaboratory (Her 2, Parvo, H. pytor, HScore). Thess ASRs are ctnicaity upetul indicaiors that do not requre FOA spprove. The3e cone: srs ustd: ID5-ER, PgR 636-PR A485=HER2, H-11=EGFR, CCH2/DOG9=CMV, F39.4.1=AR and HPV by ISH. AM wmmunonskochehica stains sre use0 with fomein or mole As the attending pathologist, f attest that i: (i) Exani(ed the relovant preparatton(s) tor the specimen(s); and (#) Rendereq the diegnosix(es). Procedures/Addenda Addendum Date Ordered: Status: Signed Out Date Complete: Date Reported: Addendum Dlagnosis A. Lymph node, sentinel lymph node,. -Keratin negative for tumor cells. B. Lymph node, sentinel lymph node,. -Keratin negative for tumor cells. C. Lymph node, sentinel lymph node, -Keratin negative for tumor cells. Addendum Date Ordered: Status: Signed Out Date Complete: Page 2 of 4
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+SURGICAL PATHOL Report Date Reported: Addendum Diagnosis The tumor cells are positive for ER and PR and negative for HER-2 by immunohistochemistry. HER-2 CISH is neg tive. Final AJCC staging pT1C N0 (sn) (i-) MX. Intraoperative Consultation AFS. Lymph node, sentinel lymph node, I ct. Lymphocytes present. No evidence of malignancy. BFS. Lymph node, sentinel lymph node, : I ct. Lymphocytes present. No evidence of malignancy. CFS. Lymph node, sentinel tymph node,': ct. Lymphocytes present. No evidence of malignancy. EfS. Additional medial nodule, FS: fibrosis, No malignancy seen. Clinical History:. {Not Provided} Pre Qperative Diagnosis: Right breast cancer. Specimen(s) Received: A: Lymph node, sentinel lymph node, B: Lymph node, sentinel lymph node. C: Lymph node, sentinel fymph node, D: Right breast mass, 1 short stitch superior, 1 long stitch lateral. E: Additional medial nodule, FS Gross Description: A. Received fresh and labeled "lymph node, sentinel lymph node, TP #1" is a segment of fibro-adlpose tlssue, 1.3 x 0.9 x 0.6 cm. Specimen bisected and submitted in toto in one cassette.. B. Received fresh and labeled *tymph node, sentinel lymph node, TP#2~ is a segment of yellow-tan, fibro-adipose tissue, 1.2 x 0.8 x 0.6 cm. Specimen bisected and submitted in toto in one cassette.. C. Received fresh and labeled "1ymph node, sentinel lymph node, TP #3" is a segment of pale-tan fibro-adipo$e tissue, 1.8 x 1.2 x 0.3 cm. Specimen submitted in toto in one cassette.. D. Received in formalin and labeled *right breast mass, 1 short stitch superior, 1 long stitch lateral" is a lumpectomy specimen measuring 5.8 x 5.8 x 2.5 cm and weighs 26.5 grams. Specimen oriented with one short stitch indicating superior and one long stitch lateral. Resection margins inked as follows: Superior margin inked blue, inferidr margin inked red, lateral margin inked orange, anterior margin inked yellow, posterior (deep) inked black. Sections of the specimen reveal and irregular shaped, ill-defined, indurate, white-tan mass, 1.7 x 1.6 x 1.6 cm. The mass is present $t 0.1 cm from the anterior margin (closest-yellow). The reminder margins are grossly uninvolved. Cassettes submitted as follows. Page 3 of 4
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+SURGICAL PATHOL Report  Mass in relation to anterior and inferior margins (yellow-green). 2 Lateral (oranged) and medial (red margin). 3 Superior (blue) and deep (black margin). 4-8 Lesions submitted in toto E. Received fresh and labeled *additional medial nodule, FS*consists of a segment of tan-yellow, fibro-adipose tissue, 2.3 x 1.0 x 0.6 cm. The true margins inked black. Representative sections submitted as follows.. Sections submitted for frozen 2 Reminder of specimen submitted in toto ICD-9(): 174.8 Page 4 ot 4
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diff --git a/output/text/cf6a0120-770a-4a90-8ee1-53ce52c264c1.txt b/output/text/cf6a0120-770a-4a90-8ee1-53ce52c264c1.txt
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index 0000000000000000000000000000000000000000..92607d27811d2418b0cc7c99c531186fe12ef9ab
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+DIAGNOSIS (A) RIGHT LARYNX: INVASIVE MODERATELY DIFFERENTIATED SQUAMOUS CELL CARCINOMA. (B)) RIgHT EXTENDED.RADICAL NECK AND LEFT mODIFIeD NECK DISSECTION AND TOTAL LARYNGECTOMY: INVASIVE MODERATELY DIFFERENTIATED SQUAMOUS CELL CARCINOMA ARISING IN THE RIGHT PYRIFORM SINUS (2.4 X 2.0 X 1.5 CM). (See COMmenT) PERINEURAL INVASION PRESENT. METASTATIC SQUAMOUS CELL CARCINOMA PRESENT IN RIGHT SUBDIGASTRIC AND MIDJUGULAR LYMPH NODES (SUBMENTAL/SUBMAXILLARY LYMPH NODes: 0/3).(see COmmenT) One left cervical lymph node, no tumor present.. Superior mucosal, inferior tracheal, and peripheral soft tissue. margins, no tumor present. Left true and faise vocal cords, left pyriform sinus, epiglottis and anterior commissure, no tumor present.. Multinodular goiter in right lobe of thyroid, no tumor present. (c) Teeth: Teeth (gross only).. COMMENT There is a 2.4 cm tumor mass obliterating the right pyriform sinus. and right aryepiglottic fold that extends into the submucosa of the right true and false vocal cord and within less than 1.0 mm of the adjacent soft tissue margin. There is a 5.0 cm tumor mass in the level 3 and 4 areas of the right neck dissection_which_appears to represent a mass of matted lymph nodes almost comnletely replaced by carcinoma.. SPECIMEN (A)  RIGHT LARYNX: (b)  RIGHT EXTENDED RADICAL NECK AND LEFT MODIFIED NECK DISSECTION AND TOTAL (c) Teeth: SNOMED CODES t-24100,m-80703 Page 1 of 1 History Case Pathology Report History Case Pathology. File under: Pathology
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diff --git a/output/text/cf9009c1-8360-461c-ad35-4ffc92f0a1e5.txt b/output/text/cf9009c1-8360-461c-ad35-4ffc92f0a1e5.txt
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index 0000000000000000000000000000000000000000..85b270946bd7b435a3bbe13d455d76f932ab008f
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+/cs-0-3 Carci oma, hepat cllule,N0s 8170/3 Sif: L/ve- C22.0 // IRB APPROVED Form Revised Clinical Case Report (For Collection of Cancerous Tissue) UUID:81F0F911-C2C1-48AD-A67F-FD455503CB46 TCGA-CC-A1HT-01A-PR Redacted  ID#: X Informed Consent I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the vith the patient and answered any questions the patient had. Ihe pauent inen sigucu ue consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Pnysician or Study Coordinator Signature Date Clinical Information GENERADINFORMATIONE Date of Birth (mm/dd/yxy) Height Marital Status Race Temperature =m 63  Single Married Gender Weight  Divorced  Widow Blood Pressure Heart Rate Male  Female 5 4 kg SZAHISTORYOEPRESENT IELNESSS Chief Complaints:Ahdouni rcul povin j Feyer Symptoms: weiqhA-wss jtined of ealiny Clinical Findings: Performance Scale (Karnofsky Score):  100 Asymptomatic   80-90 Symptomatic but Fully Ambulatory   60-70 Symptomatic, in bed less than 50% of day  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden 20-30 Bed Ridden EASSCURRENTMEDICATIONSS Drug Dose Route Frequency Date (mm/dd/yyy) To To / To To To
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+ID#: .. .... . PAST MEDICAL HISTORY Diagnosis Date Treatment Status  Diagnosis/Disease/Disorder/Injury SOBGYNHISTORY # of Pregnandies Date of First Menses.  Menopausal Statusd  Pre-menopausal # of Live Births Date of Last Mensesd  Peri-Menopausal  Post-menopausal  Hormone Replacement  Oral Contraceptive  IUD Birth Control: Condom Therapy:  Other: AATSSOCIAEHISTORYE. Environmental Hazards: Occupation: Smoking History.  Duration When Quit TyPE Packs/day Current Status (y) (yrs) O YES yDNO Alcohol Consumption Duration When Quit  Drinks/day TYPE (y) Current Status (yrs)  YES 9NO Drug Use Duration When Quit Type Freguency Current Status () (yrs)  yes 9NO GPASSONFAMILYMEDICAHHISTORYWAAS Age of Diagnosis  Diagnosis Relative Result Date SECSTLABDATAASAORA Test Result Date CEA  Negative  Positive: Test HIV Negative  Positive:   Negative  Positive:  CA 15-3 Negative  Positive: Hep B CA 19-9  Negative  Positive: DNegative  Positive: 1/ PSA   Negative  Positive: Hep C   Negative  Positive: AFP Other:  Positive:  Negative Other:  Negative  Positive: B/T Cell Markers: 2
+
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+ID#: Pathology Form Specimen Information Date 'ime Collected by: -- Date Tim Preserved by: -- SPECIMENTYPE (#of samples provided  Blood/Serum/Plasma Slide  Paraffin Biock Frozen  Normal Diseased  Normal Normal Diseased Normal Diseased 2 Diseased 2 2 4 Time to LN2 Time to Formalin Time to LN2 min 13 min min RPPATHOLOGICALDESCRIPTION Primary Tumor Extension of Tumor Distance to NAT Size Organ 6 cm li'uer temee 6 x Lx cm Lymph Nodes # Metastasized # Examined Location Distant Metastasis Size Detailed Location Organ Pathological Staging m O Stage: N o pT 3 Notes: 4
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+ID#: DIAGNOSTICSTUDIESM Study Results Date Ultrasound V X-Ray CT Endoscopy MRI  Biopsy CLINICALDIAGNOSIS Preoperative Clinical Diagnosis  Location of Suspected Involved Lymph Nodes. Location of Suspected Distant Metastasis Clinica! Staging Date of Diagnosis T3 Na M O Stage: U A- Treatment Information Procedure Date of Procedure Hendlic Reseetm. Primary Tumor Organ Detailed Location Size liver Vexek Pj ghg 6 xf x am Extension of Tumor. Lymph Nodes Description Location of Lymph Nodes # of Lymph Nodes  Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Organ Detailed Location Size Surgical Staging T 3 N m Q Stage: NEOADJUVENTTHERAPY (ChemoRadiation, ImmunoHormonalorMolecular Drug/Treatment Dose Route Frequency Date (mm/dd/yyyy) 1 To To / To 1 To / 1 To 3
+
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+CONSOLIDATED DIAGNOSTIC pATHOLOgy fORm* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION Diffuse + STRUCTURALPATTERN Mosaic Streaming Necrosis  Storiform Lymphocytic infiltration Fibrosis Vascular Invasion Patisading Chsterized Cyxic Deeeneration Alveolar Formation Bleeding Indian File Myxoid Chanre 2. Cellular features: y Psammome/Caicification Sguamous +. Adenomatous Squamoid Cell +. Sarcematous Glandular cell + Lxmphomatous Round Cell + Spindle Cell Lapre Cel Cell Stratificatioa Fibrobtast Keratin Small Cell  Secretion Osteoblast Desmosoe RS CelV/RS Like Intracyt. Vacuole Lipoblast Pear! Inftan. Cell Gland formation  Myobiast Otherwise Specified: Plasma Cell 51 757 D607 D36OZ Dg0Z NgerAtA 2.Celludar Differentiatien: Well Modermsely Nucleat Atypia: Nuckear Apesarance  Aniso Nuckeosis Hyperchromatism Nucleolar Prominent  Muttinsclemed Giant Cel) Mitotic Activity Neckear Grade Histological Diagnosis: HeDetoeel/u las Cleklsnsorg Aes C- 3 Reseexeg : cageek Qz Comments: 3 PATHOLOGIST STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR ANO
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diff --git a/output/text/d0279267-2534-4cc3-a6e3-a895fe153859.txt b/output/text/d0279267-2534-4cc3-a6e3-a895fe153859.txt
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+SURGICAL PATHOLOGY REPORT * Addendum  Clinical Diagnosis & History: with left sigmoid colon cancer. Specimens Submitted: 1: SP:  Sigmoid colon; resection 2: sp: Additional distal margin 3: SP: Proximal margin DIAGNOSIS: 1. Sp: Sigmoid colon; resection:. Tumor Type: Adenocarcinoma with mucinous features (<50% mucinous component) Histologic Grade:.  Moderately differentiated Tumor Location: Sigmoid colon Tumor Size: Length is 2.2 cm Width is 1.5 cm Maximal thickness is 0.8 cm Tumor Budding: Absent Increased Tumor Infiltrating Lymphocytes:. Absent Not identified Deepest Tumor Invasion: Subserosal adipose tissue and/or mesenteric fat. Gross Tumor Perforation: Not identified Lymphovascular Invasion: Suspected Large Venous Invasion: Not Identified Perineural Invasion:. Not identified. Surgical Margins:. Free of tumor Polyps/Mucosa Dysplasia (away from the carcinoma):. ** Continued on next page **
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+Page 2 of4 Not Identified Non-Neoplastic Bowel: Unremarkable Tattoo pigment is identified consistent with the site of a prior procedure Lymph Nodes: Number with metastasis:0 Total number examined: 20 Tumor deposits in pericolorectal soft tissue: Not Identified Tumor Staging (AJcc 7th Edition: pT3 (Tumor invades through the muscularis propria into pericolorectal tissues) Lymph Node Stage (AJcc 7th Edition): NO (No regional lymph node metastasis) 2. COLON,ADDITIONAL DISTAL MARGINRESECTION: -BENIGN SEGMENT OF COLON WITH NO PATHOLOGIC DIAGNOSIS. 3. COLON,PROXIMAL MARGIN";RESECTION -BENIGN SEGMENT OF COLON WITH NO PATHOLOGIC DIAGNOSIS. 4. COLON,DISTALMARGINRESECTION -BENIGN SEGMENT OF COLON WITH NO PATHOLOGIC DIAGNOSIS. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Special Studies: Result Special Stain Comment RECUT Gross Description: 1.) The specimen is received fresh and is labeled "sigmoid colon distal end is open.It consists of a sigmoid colon that measures 13.5 cm in length and 7.5 cm in greatest circumference. The serosal surface is tan-red and smooth. The proximal margin is inked black and the distal margin is inked blue. The specimen is opened to reveal a tumor that is located 5.0 cm from the proximal margin and 8.0 cm from the distal margin. The tumor measures 2.2 cm in length and 1.5 cm in width. Serial sectioning reveals tumor invasion to a depth of 0.8 cm, which is 0.5 cm from the closest radial margin. The remaining mucosa shows no gross anomalies. Pericolic and peri-rectal adipose tissue is thoroughly examined for lymph nodes, and all possible ** Continued on next page **
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+nodes are submitted submitted. Summary of sections: PM -  proximal margin DM -  distal margin T tumor U - uninvolved mucosa LN lymph nodes BLN - bisected lymph node 2.) The specimen is received in formalin, labeled "additional distal margin". and consists of an unoriented portion of colon measuring 1.2 cm in length and 2.0 cm in circumference. The serosa is tan-red and grossly  The mucosa is tan-gray and grossly unremarkable. The unremarkable. specimen is entirely submitted. Summary of sections: U - undesignated 3.) The specimen is received in formalin, labeled "proximal margin" and. consists of a silver metal anastomotic pin measuring 7.5 x 2.8 x 1.5 cm. At the center of the pin, a 3.2 cm plastic piece is noted. A ring of pink tan soft tissue is attached measuring 2.0 x 1.8 x 1.0 cm.  The mucosal surface is pink tan and focally hemorrhagic and the serosal surface is pink tan and smooth. Several sutures are noted. The sutures are removed and the soft tissue is entirely submitted. Summary of sections: U - undesignated 4.) The specimen is received in formalin, labeled "distal margin" and consists of a portion of pink tan soft tissue measuring 2.0 x 1.8 x 1.0 cm The mucosal surface is pink tan and focally hemorrhagic and the serosal surface is pink tan and smooth. Several sutures are noted.. The sutures removed and the specimen is entirely submitted. Summary of sections: U - undesignated Summary of Sections: ** Continued on next page **
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+Part 1: SP: Sigmoid colon; resection. Block Sect. Site PCs BLN 2 4 H 5 DM 1 LN 15 1 PM 1 5 T 5 1 U 1 Part 2: SP: Additional distal margin. Block Sect. site PCs 2 U 2 Part 3: SP: Proximal margin Block Sect. site PCs 2 U 2 Part 4: SP: Distal margin Block Sect. Site. PCs 2 U 2 Addendum Diagnosis 1. Colon, sigmoid; resection:. - The focus suspicious for lymphovascular invasion is lost on deeper. levels. An immunohistochemical stain for D2-40 does not provide evidence for lymphovascular invasion. ** End of Report.
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index 0000000000000000000000000000000000000000..1b88c70bbd21622dd56cc8fda06e5f22a3d387eb
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+SURGICAL PATHOLOGY REPORT Accession Number: Final Report DIAGNOSIS: 1) TONSIL, RIGHT, EXCISION: INVASIVE, MODERATELY-DIFFERENTIATED SQUAMOUS CELL CARCINOMA, 2.2 CM IN GREATEST DIMENSION, ALL RESECTION MARGINS NEGATIVE FOR TUMOR (SEE COMMENT). 2) SOFT TISSUE, RIGHT NECK, EXCISION: DENSE FIBROUS TISSUE AND FOREIGN BODY GIANT CELL REACTION, NEGATIVE FOR TUMOR. 3) "SOFT TISSUE," RIGHT NECK, LEVEL 1B, EXCISION: SALIVARY GLAND WITH NO SIGNIFICANT HISTOPATHOLOGIC CHANGE, NEGATIVE FOR TUMOR. 4) LYMPH NODE, RIGHT NECK, LEVEL 2-3, EXCISION: BENIGN FIBROADIPOSE TISSUE AND SKELETAL MUSCLE WITH SUTURE GRANULOMA; 11 LYMPH NODES NEGATIVE FOR TUMOR. 5) SKIN, RIGHT NECK, EXCISION: SCAR AND SUTURE GRANULOMA, NEGATIVE FOR TUMOR. 6) LYMPH NODE, LEFT NECK, LEVEL 2-3, EXCISION: 13 LYMPH NODES, NEGATIVE FOR TUMOR. 7) TONSIL, LEFT, EXCISION: NEGATIVE FOR TUMOR. 8) TOOTH, 1, 31, 32, REMOVAL: MOLAR TEETH WITH NO SIGNIFICANT HISTOPATHOLOGIC CHANGE COMMENT: This corresponds to AJCC stage II (pT2, pN0) Electronically signed by. CLINICAL DATA Clinical Features/Dx:  unspecified Operator: Operation:  unspecified Operative Findings: unspecified Operative Diagnosis: unspecified Tissue Submitted: unspecified
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+GROSS DESCRIPTION: 1) SOURCE: Tonsil, Right Received fresh is a specimen labeled, "right tonsil," consisting of a 2.8 x 2.0 x 1.1 cm tonsillectomy specimen. A 2.2 x 1.8 x 0.9 cm mass is identified on the mucosal surface of the specimen. The specimen is inked black. The specimen is serially sectioned and a portion of the specimen is obtained for future research studies. A portion of the specimen is submitted for frozen section analysis. The remainder of the specimen is submitted for permanent section.. Summary of sections: 1AFSC, 1/1; 1B-C, mass, 1B, 2/1, 1C, 3/1 2) SOURCE: Right Neck adjacent to jugular vein. Received fresh is a specimen labeled, "soft tissue right neck adjacent to jugular vein," consisting of a 0.5 x 0.4 x 0.3 cm portion of soft tissue, which is entirely submitted for frozen section analysis. Summary of sections: 2AFSC, 1/1. 3) SOURCE: Right neck level 1 B Received fresh is a specimen labeled, "right neck level 1B," consisting of a 4.0 x 3.0 x 1.0 cm portion of yellow, soft, and lobulated adipose tissue. A search for lymph nodes is performed. No lymph nodes are identified through palpation. The specimen is serially sectioned to reveal tissue consistent with a salivary gland. The specimen is entirely submitted. Summary of sections: 3A, 2/1; 3B, 1/1; 3C, 2/1; 3D, 1/1; 3E, 1/1. 4) SOURCE: Right neck level 2 + 3 Received fresh is a specimen labeled, "right neck level 2-3," consisting of two fragments of fibroconnective and adipose tissue, measuring 5.0 x 4.5 x 1.0 cm in aggregate. A search for lymph nodes is performed. The specimen is serially sectioned and entirely submitted. Summary of sections: 4A, fragment of fibroconnective tissue, bisected. 1/1; 4B, three lymph nodes, 3/1; 4C, one lymph node, bisected, 2/1; 4D, three lymph nodes, 3/1; 4E-G, fragment of fibroconnective tissue, serially sectioned, 1/1 each. 5) SOURCE: Right neck scar Received fresh is a specimen labeled, "right neck scar," consisting of a 7.0 x 0.7 x 0.4 cm portion of skin and subcutaneous tissue. A 6.0 cm scar is identified on the cutaneous surface of the specimen. The specimen is not oriented. The subcutaneous tissue is inked black. The specimen is serially sectioned and entirely submitted. Summary of sections: 5A, tips, 2/1; 5B-C, scar, 5B, 8/1, 5C, 6/1. 6) SOURCE: Left neck level 2,3 Received fresh is a specimen labeled, "left neck level 2-3," consisting
+
+--- Page 3 ---
+of a 7.0 x 3.0 x 1.0 cm portion of fibroadipose tissue. A search for. lymph nodes is performed. A representative portion of the specimen containing lymph nodes is submitted. Summary of sections: 6A, four lymph nodes, 4/1; 6B, three lymph nodes,. 3/1; 6C, portion of fibroconnective tissue, 1/1. 7) SOURCE: Tonsil , Left. Received fresh is a specimen labeled, "left tonsil," consisting of a tonsillectomy specimen, measuring 2.5 x 1.5 x 1.0 cm. The specimen reveals extensive cautery artifact. The specimen is inked black, serially sectioned and entirely submitted. Summary of sections: 7A-B, tonsil, 2/1 each 8) SOURCE: Teeth; 1,31,32 Received fresh is a specimen labeled, " teeth, 1, 31, 32," consisting of molar teeth with attached minimal amount of soft tissue, showing no significant histopathologic changes. The specimen is filed in the medicolegal file. No tissue is retained for permanent section. This is a. gross diagnosis only. Dictated by Slides and report reviewed by Attending Pathologist. SURGICAL PATHOLOGY INTRAOPERATIVE CONSULTATION 1) SOURCE: Tonsil, Right. FROZEN SECTION DIAGNOSIS: SQUAMOUS CELL CARCINOMA 2) SOURCE: Right Neck adjacent to jugular vein FROZEN SECTION DIAGNOSIS: FIBROSIS AND FOREIGN BODY GIANT CELL REACTION; BENIGN Electronically signed by: Pathologist SNOMED: T-C5100,M-80103, Release of Information
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+Ics-0-3 Carcioma, Jnfil+natay cluct NoS 8500/3 Sit Cude: brsst, NOs cSo.9 12-11/10 TSS Pt ID: SPECIMENS: UUID:DDBEE56C-F8E8-4A7D-8CF6-E0D63EE53FC4 A. SENTINEL LYMPH NODE #1 RIGHT AXILLA TcgA-E2-A108-01a-Pr Redacted B. SENTINEL LYMPH NODE #2 RIGHT AXILLA C. RIGHT BREAST LUMPECTOMY D. RIGHT AXILLARY CONTENTS LEVELS 1 AND 2 E. SUPERIOR MARGIN F. MEDIAL MARGIN G. INFERIOR MARGIN SPECIMEN(S): A. SENTINEL LYMPH NODE #1 RIGHT AXILLA B. SENTINEL LYMPH NODE #2 RIGHT AXILLA C. RIGHT BREAST LUMPECTOMY D. RIGHT AXILLARY CONTENTS LEVELS 1 AND 2 E. SUPERIOR MARGIN F. MEDIAL MARGIN G. INFERIOR MARGIN INTRAOPERATIVE CONSULTATION DIAGNOSIS: TPA1: LN positive for carcinoma (SLN #1) TPB1 and TPB2: LY negative for carcinoma (SLN #2) C: Gross: Right breast, 1st lesion 2.2 cm, at distance from all margins (1.5 from closest superior margin) 2nd lesion 3.0 cm from the 1st lesion, size 0.8 cm, 0.4 cm from the closest inferior margin. By Dr. called to Dr. at.  A, B) ana () GROSS DESCRIPTION: A. SENTINEL LYMPH NODE #1 RIGHT AXILLA Received fresh labeled with the patient identification and "sentinel lymph node #1", is a 2.0 x 1.0 x 0.8- cm fatty lymph node displaying a 0.5 x 0.4 x 0.4-cm firm white tumor nodule. Touch preparations are performed. The lymph node is representatively submitted in cassette A1. B. SENTINEL LYMPH NODE #2 RIGHT AXILLA Received fresh labeled with the patient identification and "sentinel lymph node #2, right axilla", are 2 tan-pink to fatty lymph nodes, 0.5 cm (B1) and 1.2 x 0.6 x 0.5 cm (B2). A touch preparation on each lymph node is performed and the lymph nodes are entirely submitted as follows: B1: Smaller lymph node B2: Largest lymph node C. RIGHT BREAST LUMPECTOMY Received fresh labeled with the patient identification and "right breast lumpectomy", is an oriented (single - anterior, double - lateral, triple - superior), 153.0-gram, 11.5 x 8.5 x 3.0-cm needle localized Iumpectomy with radiograph. Ink code: Anterior - yellow, posterior - black, medial - green, lateral - red, superior - blue, inferior - orange. The specimen is serially sectioned into 9 slices revealing a 2.2 x 1.8 x 1.8-cm infiltrative firm gritty white tumor (mass #1 - 12 o'clock). Mass #1 is closest to the anterior and superior margins at 1.5 cm each. Tissue is procured. There is a second mass/biopsy site, 0.8 cm which is closest to the inferior margin at 0.4 cm and 3.0 cm from the first mass. The remaining fibrous tissue is finely lobulated with interspersed clear fluid-filled 0.2-cm cysts. No additional nodules are identified. A gross evaluation is performed. Representatively submitted: C1: Slice 1, medial margin, perpendicular C2-C3: Slice 4, tumor to closest anterior superior margins C4-C6: Slice 6, tumor to superior posterior margins. C7: Slice 6, anterior margin C8: Slice 6 C9: Slice 6, posterior margin C10: Slice 6, anterior margin C11: Slice 6 C12: Slice 6, posterior margin C13: Slice 7, superior margin C14: Slice 7, anterior margin C15: Slice 7, posterior margin C16: Slice 7, anterior margin
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+--- Page 2 ---
+C17: Slice 7 C18: Slice 7, posterior margin C19: Slice 7, anterior margin C20: Slice 7, mass #2/biopsy cavity C21: Slice 7, posterior margin C22: Slice 9, lateral margin, perpendicular D. RIGHT AXILLARY CONTENTS LEVELS 1 AND 2 Received in formalin labeled with the patient identification and "right axillary contents levels 1 and 2", is. a 9.0 x 5.0 x 1.8-cm portion of adipose tissue, within which 20 possible lymph nodes are identified ranging from 0.2 to 3.5 cm. There are 2 tan-pink to fatty lymph nodes exhibiting infiltrative tumor, 0.4. and 0.5 cm. Also identified are 3 matted lymph nodes with an overall dimension of 2.2 cm. The specimen is representatively submitted as follows:. D1: Four whole lymph nodes D2: Four whole lymph nodes D3: Three whole lymph nodes D4: One lymph node bisected D5: One lymph node bisected D6: Two whole lymph nodes D7: Two positive lymph nodes D8: Three possible matted lymph nodes D9-D20: Remaining soft tissue E. SUPERIOR MARGIN Received in formalin labeled with the patient identification and "new superior margin", is a 5.0-gram, 6.0. x 2.0 x 0.8-cm oriented portion of breast (suture at final margin). The final margin is inked black and on. serial sectioning, no discrete lesions are identified. Entirely submitted in cassettes E1-E4. F. MEDIAL MARGIN Received in formalin labeled with the patient identification and "medial margin", is an oriented (suture at. final margin) 5.0-gram, 4.5 x 2.8 x 1.7-cm fibrofatty tissue. The final margin is inked black and on serially sectioning, no discrete lesions are identified. Entirely submitted in cassettes F1-F4. G. INFERIOR MARGIN Received in formalin labeled with the patient identification and "inferior margin", is an oriented (suture at. final margin) 4.0-gram, 4.0 x 1.5 x 1.3-cm fibrofatty tissue. The final margin is inked black and on serially sectioning, no discrete lesions are identified. Entirely submitted in cassettes G1-G3. DIAGNOSIS: A. LYMPH NODE, SENTINEL #1, RIGHT AXILLA, EXCISION:  METASTATIC CARCINOMA TO ONE OF ONE LYMPH NODE (1/1), MEASURING 0.4-CM WITH NO EXTRANODAL EXTENSION. B. LYMPH NODES, SENTINEL #2, RIGHT AXILLA, EXCISION: - TWO LYMPH NODES, NEGATIVE FOR METASTASES (0/2). C. BREAST(RIGHD, WIDE LOCAL EXCISION: - INVASIVE DUCTAL CARCINOMA, SBR GRADE 3, MEASURING 2.2-CM - HIGH NUCLEAR GRADE, DUCTAL CARCINOMA IN SITU, SOLID TYPE WITH CENTRAL NECROSIS AND LOBULAR EXTENSION - SURGICAL RESECTION MARGINS NEGATIVE FOR TUMOR - BIOPSY SITE CHANGES WITH FIBROSIS AND GRANULATION TISSUE - SEE SYNOPTIC REPORT AND SEE NOTE. D. LYMPH NODES, RIGHT AXILLARY CONTENTS, LEVELS 1 AND 2, DISSECTION: - METASTATIC CARCINOMA TO FOUR OF TWENTY FOUR LYMPH NODES (4/24), LARGEST MEASURING 1.0-CM WITH FOCAL EXTRANODAL EXTENSION. E. BREAST. SUPERIOR MARGIN, EXCISION: - BREAST TISSUE, NO TUMOR SEEN. F. BREAST, MEDIAL MARGIN, EXCISION: - BREAST TISSUE, NO TUMOR SEEN. G. BREAST, INFERIOR MARGIN, EXCISION: - BREAST TISSUE, NO TUMOR SEEN.
+
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+NOTE: Grossly, two tumor masses are identified, one larger located in the superior anterior and one smaller located in the inferior lateral aspect of the specimen. The larger mass is composed of invasive ductal carcinoma measuring 2.2-cm. The smaller tumor is composed of biopsy site changes with granulation tissue intermixed with clusters of neoplastic ducts located only in the lymphatic channels (CD31 and D2-40 mark involved spaces). Located in the same level (slice #7) more towards the center of the specimen is a microscopic focus of DCiS. SYNOPTIC REPORT - BREAST Specimen Type: Excision Needle Localization: Yes Laterality: (Right)  Invasive Tumor: Present Multifocality: No WHO CLASSIFICATION Invasive ductal carcinoma, NOs 8500/3 Tumor size: 2.2cm Tumor Site:  Not specified. Margins: Negative Tubular Score: 3 Nuclear Grade: 3 Mitotic Score: 3 Modified Scarff Bloom Richardson Grade: 3 Necrosis: Absent Vascular/Lymphatic Invasion: Present Extent: at 9:00 position Lobular neoplasia: None Lymph nodes: Sentinel lymph node and axillary dissection Lymph node status:  Positive 5 / 27 Extranodal extension. Micrometastases: No DCIS present Margins uninvolved by DCIS DCIS Quantity: Estimate 2% DCIS Type: Solid DCIS Location:  Separate from invasive tumor mass. Nuclear grade: High Necrosis: Present ER/PR/HER2 Results ER: Positive PR: Positive HER2: Negative Performed on Case: Pathological staging (pTN): pT 2 N 2a CLINICAL HISTORY: -year-old female multifocal IDC right breast, 2 areas at 12 and 9 o'clock. Now for lumpectomy/SNB PRE-OPERATIVE DIAGNOSIS:  None given Gross Dictation: Pathologist, Microscopic/Diagnostic Dictation: Patholoqist, . Final Review.., Pathologist,. Final: Pathologist, : :
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diff --git a/output/text/d03511ec-d026-4e9c-be31-70004648c964.txt b/output/text/d03511ec-d026-4e9c-be31-70004648c964.txt
new file mode 100644
index 0000000000000000000000000000000000000000..eb028116b1d579fa9e4042ad5b852ec5fa076619
--- /dev/null
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+
+--- Page 1 ---
+CGA-A6-2678 SPECIMEN A. Transverse colon. B. Appendix CLINICAL NOTES PRE-op DIAgnosis: Please check for microsatelite instability on specimen A GROSS DESCRIPTION Received fresh, subsequently fixed in formalin labeled. "transverse colon" is a transverse colon with an abundant portion of omentum attached. The omentum is 70.0 x 15.0 x 1.2 cm. The omentum. specimen is sectioned and palpated to show no discrete gross lesions identified. Also attached to the specimen is a transverse colon with partially covered abundant yellow lobular fat. The specimen is 35.0 and stapled at both ends and arbitrarily inked blue and black. The specimen is predominantly covered with abundant lobular fat and the previously described omentum. The specimen is opened to show pink-tan smooth glistening mucosa with normal to slightly flattened folds having an average circumference of 6.5 cm. There is a large exophytic lesion which is 4.5 x 4.2 x 1.0 cm and is 14 cm from the nearest margin of excision. The tumor grossly involves the muscularis propria and into the serosa. There is a 1.2 cm. umbilication in the serosa. The tumor is contiguous with this site. The cut surface of the tumor shows no discrete invasion into the fatty tissue. It comes within 7 cm. of the radial margin. No other discrete gross lesions are identified in the mucosa. Lymph nodes are grossly identified. Representative sections of the specimen are submitted as follows: Block 1 - representative section of omentum; 2 - representative luminal margins; block 3-5 - representative section of tumor normal, tumor serosa and tumor fat; block 6 -- representative radial margin; block 7 - representative normal; 8-11 - nine possible lymph nodes each; 12 - one possible lymph node GROSS DESCRIPTION bisected; 13 - one possible lymph node sectioned. Rs-13.
+
+--- Page 2 ---
+B. Received in formalin labeled "appendix" is a 9.5 x 0.5  cm. appendix which is partially covered with pink tan smooth glistening serosa and abundant yellow lobular fat. The specimen is sectioned to show an intact wall with an average thickness of 0.3 cm. The lumen ranges from pinpoint to 0.4 cm. and is partially filled with green fluid feces. No discrete gross lesions are identified. Representative sections of the specimen submitted in one cassette with the proximal ending. Rs1.. are MICROSCOPIC DESCRIPTION Histologic type: Adenocarcinoma. Histologic grade: The tumor is predominantly moderately. differentiated with focal poorly differentiated carcinoma. identified. Primary tumor (pT): The tumor extends through the wall into the. adjacent pericolonic tissue, pT3. Proximal margin: Negative for tumor. Distal margin: Negative for tumor. Circumferential (radial) margin: Tumor comes to within 0.1 cm of. the serosal surface of the specimen; the radial margin is negative. Distance of tumor from closest margin: 14 cm Vascular invasion: Not identified. Regional lymph nodes (pN): Two of 26 lymph nodes positive for metastatic carcinoma (2/26). Distant metastasis (pM): pMx. 5x1, 2x1 DIAGNOSIS A. Colon, transverse, excision - Invasive adenocarcinoma (see tumor characteristics in the microscopic description). Tumor is submitted for microsatellite instability testing and an addendum will be issued when the report is received. B.  Appendix, appendectomy - Appendix with fibrous obliteration of the tip..
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diff --git a/output/text/d038710f-c654-462b-ace5-f0067e8a91d6.txt b/output/text/d038710f-c654-462b-ace5-f0067e8a91d6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c70b6fa2c0fe541a16965d235ef48d51a92d3823
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+UUID: 2FE90807-3C01-4956-B565-A5A18A08C93C TCGA-ED-A82E-01A-PR Redacted TSS Patient ID Surgical Date: Gross Description: Tumor is located in a lobe, ill-margins with 6x6x4cm in size, firm, solid, necrotic gray. white in cutting section.. Microscopic Description: Tumor cells form the trabecular patterns, or acinar or sheets or tubular. patterns. The tumor cells retain apolygonal shape and have round vesicular nuclei with prominent. nucleoli. The amount of cytoplasm are moderate and the cytoplasm is basophilic or vascuolated. Nuclei are irregularly large and hyperchromatic with prominent nucleioli. Mitoses are present. Tumor is focal necrotic. Diagnosis Details: Hepatocellular carcinoma, moderately-differentiated. Comments: IcD-O-3 Formatted Path Reports: LIVER TISSUE CHECKLIST areroms, hepatoce Ilules NOS Specimen type: Lobectomy 8170|3 Tumor size: 10 x 10 x 8 cm S.ite:oner NoS CqQ.O Focality: Not specified. JtJ 1o|30|L3 Histologic type: Hepatocellular carcinoma Histologic grade: Moderately differentiated. Tumor extent: Not specified. Lymph nodes: Not specified. Venous invasion: Not specified. Margins: Uninvolved. Evidence of neo-adjuvant treatment: No Additional pathologic findings: Not specified. Comments: None QUAL'FICD
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diff --git a/output/text/d03f8995-0c6f-41e8-8522-a8956791257b.txt b/output/text/d03f8995-0c6f-41e8-8522-a8956791257b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7fbf431a1535891ffaf5fe27d319e78ff43c7ca2
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+page 1 / 2 Department of Cancer Pathology Date: Examination: Intraoperative examination Examination No.:. Patient: xxx PESEL: XXX Age Gender: F icd-0-3 Material: Lesion excision -- right breast. Carci tmr, mfi/tnstng dwet,nos P5 o0 Unit in charge: Siter bust,Nos C50.9 Internal referra! pw 4f1H/1 Physician in charge: Material collected on' Material received on: Expected time of examination: 20 minutes (from receipt of material) Clinical diagnosis: Cancer of the right breast - marked with 1 thread for sternum, 2 threads for the shoulder, 3 threads for the axilla. Please, review the margins. Examination performed or Result of intraoperative examination: Carcinoma invasivum mammae 1.1 cm in diameter Final response to be given after paraffin specimens are analysed Compliance validated by : Results of immunohistochemical examination:. Estrogen receptors found in over 75% of neoplastic cell nuclei.  Progesterone receptors found in over 75% of neoplastic cell nuclei. HER2 protein stained with HercepTesttM by DAKO. Negative reaction in invasive cancerous cells ( Score = 1+ ) Compliance validated by. Examination performed on: Macroscopic description: Partial reaction of the mammary gland; Fragment of the breast sized 6.7 x 5.7 x 3.8 cm with a skin flap of 5.3 x 1.6 cm. We marked typically.. Tumour sized 1.1 x 0.6 x 0.8 cm in the cross section. Margins: 0.8 cm to the base; 1.9 cm to the skin; 3.4 cm to the edge of. sternum; 1.8 cm to the axilla, 1.4 cm to the shoulder; 1.3 cm to the lower boundary.. Microscopic description: Carcinoma ductale invasivum mammae dextrae NHG1 (2 + 2 + 1/2 mitoses/10 HPF - visual area of 0.55 mm). The largest. dimension of the lesion 1.1 cm. Margins of normal tissues as in the macroscopic description. Glandular tissue showing lesions of the type mastopathia fibrosa partim lipomatosis.. UUID:7E48315C-3717-40DB-8773-710070AFC4780 TCGA-D8-A1XM-01A-PR Redacted
+
+--- Page 2 ---
+page 2 / 2 Examination: Intraoperative examination xamination No.: Patient: xxx PESEL: XXX Gender: F Examination performed on: Histopathology diagnosis: Carcinoma ductale invasivum mammae dextrae. Invasive ductal carcinoma of the right breast. NHG1, pT1c, pN0/sn/. Compliance validated by CONTACT YOUR DOCTOR WITH THIS REPORT!
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diff --git a/output/text/d04e2b9a-b16b-4f8f-bac8-047c4bbc21cb.txt b/output/text/d04e2b9a-b16b-4f8f-bac8-047c4bbc21cb.txt
new file mode 100644
index 0000000000000000000000000000000000000000..608588736cbe3c1d1bfc503cd0e042f95784364f
--- /dev/null
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+--- Page 1 ---
+TCGA-D5-6541 Examination: Histopathological examination Material: . Partial organ resection - descending colon Physician in charge:. Material collected on  Material received on Expected time of examination: up. Clinical diagnosis: Cancer of the splenic flexure. Examination performed on. Macroscopic description:. 17 cm length of intestine with periintestinal fat tissue sized 16 x 6 x 3 cm. Two cauliflower tumours sized 3.5 x 3 x 1.5 and 2 x 3 x 1.5 cm found in the mucosa. The tumours lie in one line covering the whole circumference. Lesions placed 4 cm from on of the excision lines and 2.5 cm from the opposite one. Macroscopically, the lesion invades through the muscular membrane. Minimum side margin 3 cm.. Microscopic description: Adenocarcinoma tubulopapillare (G1). Infiltratio carcinomatosa tunicae muscularis propriae et telae adiposae pericolicae. Minimum side margin is 3 cm. Excision lines free of neoplastic lesions. Sinus histiocytosis lymphonodorum (No XIII). Histopathological diagnosis:. Adenocarcinoma tubulopapillare bifocal coli. Tubulopapillar bifocal adenocarcinoma of the colon. (G1, Dukes B, Astler-Coller B2, pT3, pN0). CONTACT YOUR DOCTOR WITH THIS REPORT!
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diff --git a/output/text/d056f23e-3703-4fff-a340-6b472953d76c.txt b/output/text/d056f23e-3703-4fff-a340-6b472953d76c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..856422535020177d0b90d57073e93572db6e62bb
--- /dev/null
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+--- Page 1 ---
+Procurement Date Laterality:Left- UOQ Path Report:BREAST TISSUE CHECKLIST 1CD-o-3 Specimen type: Radical mastectomy carcinwma,1Obwar, i^FHating Specimen size: Not specified 8520|3 Tumor site: Breast Si+e:byea<t n0S Tumor size: 3.5 x 3.5 x 3.5 cm CS 9 Grossly evident lesion: Yes 5 i7-iz eD Histologic type: Lobular carcinoma Histologic grade: Not specified Tumor extent: Not specified Lymph nodes: 4/8 positive for metastasis (Axillary 4/8) Extracapsular invasion of the lymph nodes: Not specified Margins: Not specified Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: ER,PR-8 points, HER2NEU-0 UUID:00058FFD-35E6-4891-8801-DAB3AE9EBF78 Redacted
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diff --git a/output/text/d081b055-3eb5-428c-8d60-506ece552dc8.txt b/output/text/d081b055-3eb5-428c-8d60-506ece552dc8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d1163d6946bad76d89229e9ec5556c5e2576680f
--- /dev/null
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+
+--- Page 1 ---
+Diagnosis: This is a right-sided hemicolectomy preparation with a moderately differentiated. adenocarcinoma (in the ascending colon) of histopathological differentiation grade G2, with erosions of the inner tumor surface, with carcinomatous lymphangitis, with tumor infiltration of the colon wall layers into the pericolic fatty connective tissue with peritumorous chronic recurrent secondary inflammation with an acute inflammatory flare, with focal extracellular mucus formation in the tumor tissue, with tumor-free lymph nodes (0/16) with a moderate chronic lymphadenitis and with tumor-free overview slices from all other resection material portions described. There is also a chronic appendicitis. According to the section preparations available, the tumor spread of the colon carcinoma corresponds to a tumor stage of pT3, pN0 (0/16), MX, L1, R0.. Tumor classification: ICDO-DA-M 8140/3, G2 11+
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diff --git a/output/text/d0855d6b-34a7-42b5-b61e-640da2cecdfd.txt b/output/text/d0855d6b-34a7-42b5-b61e-640da2cecdfd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..63bb53cbd10e6dbbccbe60439b7a938e57049366
--- /dev/null
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+--- Page 1 ---
+Diagnosis This concerns a tubulovillous adenoma of the colon mucosa with mild dysplasia of the cylindrical epithelium (in I).. II concerns a right hemicolectomy preparation with a slightly differentiated mucinous adenocarcinoma with histopathological differentiation grade G 3, with significant extracellular mucus accumulation, with chronic recurrent inflammation, with acute inflammatory activity, with fine focal necroses, with erosion of the inner surface of the tumor, with tumor infiltration of the colon wall layers up to the pericolic fatty connective tissue, with carcinomatous lymphangitis, with tumor-free lymph nodes (0/36), with. moderate chronic lymphadenitis, with chronic appendicitis and with tumor-free overview slices from all other resection sections described. In relation to the section preparations examined, the spreading of tumor of the colon. carcinoma corresponds to tumor stage p T 3, p N 0 (0/36), MX, L1, R0. Tumor classification: ICDO-DA M 8480/3 G3
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diff --git a/output/text/d093949a-ef60-4a74-bb30-c3eac65a9e2e.txt b/output/text/d093949a-ef60-4a74-bb30-c3eac65a9e2e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0e042ef7a153b2d0fceb6bf454e16ee995b68cb9
--- /dev/null
+++ b/output/text/d093949a-ef60-4a74-bb30-c3eac65a9e2e.txt
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+
+--- Page 1 ---
+1ed-0- 3 Carcinorna mnfil rrahing duct, N05 8500[ 13/8/10 Pasth C50, 2 c509 CqcF Siti brot, N09 TSs UUID:6C8856C1-330B-4116-8860-7A81A19832770 TCGA-E2-A14T-01A-PR Redacted SPECIMENS: A. SLN #1 B. SLN #2 C. SENTINEL NODE #3 LEFT AXILLA D. LEFT BREAST AND LOWER AXILLA TAILS SPECIMEN(S): A. SLN #1 B. SLN #2 C. SENTINEL NODE #3 LEFT AXILLA D. LEFT BREAST AND LOWER AXILLA TAILE GROSS DESCRIPTION: A. SLN #1  Received fresh are two tan pink lymph nodes 0.9 x 0.6 x 0.5cm and 0.5 x 0.4 x 0.2cm. The specimen is serially sectioned and two touch preps are taken.. A1: 1 lymph node A2: 1 lymph node B. SLN #2  Received fresh is a tan pink lymph node 0.6 x 0.4 x 0.3cm. The specimen is serially sectioned and a touch prep is taken. Toto Bt. C. SLN #3 LEFT AXILLA Received fresh is a tan pink lymph node 1.1 x 0.9 x 0.6cm. The specimen is serially sectioned and a touch prep is taken. Toto C1. D. LEFT BREAST AND LOWER AXILLA-Stitch in axilia  Received fresh is an oriented 1314g, 30 x 28 x 6cm mastectomy with 15 x 6cm tan pink skin ellipse, 1.2 cm centrally Iocated, partially raised nipple and 1.5 cm areolar rim. The specimen is inked as follows: Anterior/Superior-Blue, Anterior/Inferior-Orange, Posterior-Black. The specimen is serially sectioned from medial to lateral into 12 slices, slice 1 being most medial, slice 12 being most lateral. The nipple is located in slice 7. The cut surfaces reveal a gray white ill defined firm mass 3.5 x 2.8 x 2cm, 1.8cm from the deep margin located in slices 4, 5, 6 and 7. The area  surrounding the mass is remarkable for fibrosis and possible fat necrosis. The lower axillary tail is 6 x 5 x 3cm. Dissection reveals 4 possible lymph nodes ranging from 0.5 x 0.5 x 0.5cm to 0.8 x 0.8 x 0.5cm. A portion of the specimen is submitted for tissue procurement. Representative sections are submitted as follows: D1: nipple slice 7 D2: base of nipple slice 7. D3: UIQ area next to mass slice 3 D4-D5: mass bisected UIQ slice 4 D6: anterior margin UIQ slice 4 D7: deep margin UIQ slice 4 D8: mass UIQ slice 5 D9: deep margin UIQ slice 5 D10: skin slice 5 D11-D12: mass UIQ slice 6 D13: deep margin UIQ slice 6 D14: LIQ slice 6 D15-D16: mass bisected UC slice 7 D17: deep margin UC slice 7 D18: LC with inferior margin slice 7 D19: UOQ next to mass slice 8 D20: LOQ slice 8 D21: 2 lymph nodes D22: 2 lymph nodes D23-D26: lower axillary tissue DIAGNOSIS: A. SENTINEL LYMPH NODE #1, LEFT BREAST, BIOPSY: - TWO LYMPH NODES, NEGATIVE FOR CARCINOMA (0/2). B. SENTINEL LYMPH NODE #2, LEFT BREAST, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR CARCINOMA (O/1). C. SENTINEL LYMPH NODE #3, LEFT BREAST, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR CARCINOMA (0/1).
+
+--- Page 2 ---
+D. BrEaSt, Left, mAStectOmy:E - INVASIVE DUCTAL CARCINOMA, MODERATELY DIFFERENTIATED (SBR GRADE 2), WITh mICrOPaPILLARY fEATURES (SEE nOTE). - TUMOR MEASURES 3.5 CM IN GREATEST DIMENSION. - MARGINS, NEGATIVE FOR CARCINOMA. - DUCTAL CARCINOMA IN SITU, CRIBRIFORM AND SOLID TYPES, NUCLEAR GRADE 2, WITH NECROSIS AND MICROCALCIFICATIONS,  MINOR COMPONENT. - PREVIOUS BIOPSY SITE CHANGES PRESENT.  - SKIN AND NIPPLE, NEGATIVE FOR CARCINOMA. - THREE LYMPH NODES, NEGATIVE FOR CARCINOMA (0/3) NOTE: A CD31 immunostain has been ordered to rule out lymphvascular invasion and ER, PR, and Her FISH has been ordered. Those results will be reported in an addendum. SYNOPTIC REPORT - BREAST Specimen Type: Mastectomy Needle Localization: No Laterality:  Left Invasive Tumor: Present Multifocality: WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Tumor size: 3.5cm Tumor Site: Upper inner quadrant Margins: Negative Distance from closest margin:. Greater than 1cm deep Tubular Score: 3 Nuclear Grade: 2 Mitotic Score: 2 Modified Scarff Bloom Richardson Grade: 2 Necrosis: Absent Lobular neoplasia: None Lymph nodes: Sentine! lymph node only Negative 0/7 Lymph node status: DCIS present  Margins uninvolved by DCIS DCIS Quantity: Estimate 5% DCIS Type: Solid Cribriform DCIS Location:Associated with invasive tumor Nuclear grade: Intermediate. Necrosis: Present DCIS Location of CA++: Pathological staging (pTN): pT 2 N 0 CLINICAL HISTORY:  year old with multifocal Invasive Cancer in Upper Inner Quadrant of Left Breast PRE-OPERATIVE DIAGNOSIS: Left Breast Cancer INTRAOPERATIVE CONSULTATION: . y Dr. TPA/TPB/TPC: Negative for tumor. Diagnosis called to Dr. at ADDENDUM: RESULTS: SUMMARY OF IMMUNOHISTOCHEMISTRY/SPECIAL STAINS Material: Block D12 Population: Tumor Cells Stain/Marker: Result: Comment: CD31 Negative Shows no evidence of lymphvascular invasion
+
+--- Page 3 ---
+The interpretation of the above immunohistochemistry stain or stains is guided by published results in the medica!  literature, provided package information from the manufacturer and by internal review of staining performance and. assay validation within the Immunohistochemistry Laboratory. The use of one or more reagents in the above tests is regulated as an analyte specific reagent (AsR). These tests were developed and their performance characteristic determined by the Department of Pathology Laboratory. They have not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary.. Special stains and/or immunohistochemical stains were performed with appropriately stained positive and negative controls. SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimen: Surgical Excision Block Number: D11 ER: Positive Allred Score: 8 = Proportion Score 5 + Intensity Score 3 PR: Positive Allred Score: 4 = Proportion Score 2 + intensity Score 2 COMMENT:  The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cells staining. 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate. intensity of staining, 3 = strong intensity of staining), with a scoring range from 0 to 8. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than. or equal to 2.  METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Immunohistochemistrv was performed using the mouse anti-human ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) provided by Dako , following the manufacturer s instructions. This assay was not modified. Interpretation of the ER/PR immunonistocnemical stain is guided by published results in the medical literature,  information provided by the reagent manufacturer and by internal review of staining performance. PathVysion HER-2 DNA Probe Kit Case No Analytical Interpretation of Resuits: HER-2 NOT AMPLIFIED Clinicai Interpretation of results Amplification of the HER-2 gene was evaluated with interphase fluorescence in-situ  hybridization (FiSH) on formalin-fixed paraffin embedded tissue sections using a chromosome 17 centromeric probe and a HER-2 probe that spans the entire HER-2 gene in the by Dr. A majority of tumors cells displayed extensive polysomy 17 wtn 4 to 5 chromosome 17 signals and 2 to 3 HER-2 signals, with a HER-2/CEP 17 Ratio </=2.0, consistent with no amplification of the HER2/neu gene. Block used D11 Source of case: Tissue fixation formalin-fixed tissueOutside Case No: NA Tissue source breast Results interpreted: yes HER2/CEP17 ratio: 1.29  This ratio is derived by dividing the total number of LSI HER-2/neu signals by the total number of CEP17 signals in at least 20 interphase nuclei with nonoverlapping nuclei in the neoplastic  mammary epithelial cells. Cells with no signals or with signals of only one color are disregarded. Method of ratio enumeration: manual count Limitations The Vysis PathVysion Kit is not intended for use to screen for or diagnose breast cancer. it is intended to be used as an adjunct to other prognostic factors currently used to predict disease-free  and overall survival in stage Il, node-positive breast cancer patients. In making decisions regarding adjuvant CAF treatment, all other available clinical information should also be taken into consideration, such as tumor size, number of involved lymph nodes, and steroid receptor status. No. treatment decision for stage II, node-positive breast cancer patients should be based on HER-2/neu.  gene amplification status alone. Overview of this test  FDA APPROVED REAGENT  PathVysion HER-2 DNA Probe Kit is FDA approved for selection of patients for whom Herceptin therapy is being considered. These tests were performed in the
+
+--- Page 4 ---
+under the direction of Dr. The results of these studies should always be interpreted in the context of the clinical, morphological, and immunophenotypic diagnosis. Gross Dictation: Pathologist, Microscopic/Diagnostic Dictation: Patholoaist Final Review: Patholoaist Final: Pathologist Addendum: Pathologist, Addendum Final: Patholoaist. Addendum: Pathologist, Addendum Final: Patholy
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diff --git a/output/text/d0c8b27e-7a59-435e-86bf-dd02d30ffe01.txt b/output/text/d0c8b27e-7a59-435e-86bf-dd02d30ffe01.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e1df80ad2dab36a98182e7f470c271663fb31fb8
--- /dev/null
+++ b/output/text/d0c8b27e-7a59-435e-86bf-dd02d30ffe01.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID: 870F0307-FD8D-4ADB-82EC-118A27D591B2 Do 3 TCGA-Y8-A896-01A-PR Redacted a sineme ysapllxey nnal 8260|3 Cercurma Research Gross Description Jub DYdreey NOg male with left renal mass C64.9 Research Dx S/2z|i3 Left kidney, radical nephrectomy: Papillary renal cell carcinoma. Please see case summary. CASE SUMMARY FOR NEPHRECTOMY FOR RENAL CELL CARCINOMA: Procedure: Radical nephrectomy Specimen laterality: Left Tumor site: Middle Tumor size: 6 cm Extent of disease: Tumor extension into renal sinus. Histologic type: Papillary renal cell carcinoma Sarcomatoid features: Present, 10% Tumor necrosis: Present Histologic grade (Fuhrman Nuclear Grade): 4 Margins: Negative Lymphovascular invasion: Not identified Pathologic staging (pTNM): Primary tumor: pT3a (tumor invades renal sinus fat but not beyond Gerota's fascia). Regional lymph nodes: No lymph nodes submitted. Number examined: 0 Numer involved: Not applicable Distant metastasis: pM-not applicable Pathologic findings in nonneoplastic kidney: Peritumoral interstitial chronic inflammation and sclerosed glomeruli; arteriolonephrosclerosis. Other tumors and/or tumor-like lesions: Small renal cyst; negative adrenal gland AJCC Staging (7th edition) pT3a pNX pM-not applicable QC Research QC Tumor: 95% tumor nuclei 0% necrosis 5% normal Normal: 100% kidney and adipose Research Specimen Specimen Process Time Plasma/serum/buffy coat Cold ischemia start time:
+
+--- Page 2 ---
+Plasma frozen @ Serum frozen @ Buffy coat frozen @. Tissue: Cold ischemia start time:. Formalin fixation start time:. Total cold ischemia time:. Formalin fixation stop time. Total formalin fixation time:. Specimen Weight Normal 1- 290 mg, 520 mg, 3- 300 mg, 4- 320 mg Tumor 1- 650 mg, 2- 600 mg, 3- 690 mg, 4- 890 mg Specimen Size. Plasma x 3 Serum x 2 Buffy coat x 1 Cryovials x 8 Normal x 4 Tumor x 4 Metastatic - N/A FFPE x 8 Normal x 4 Tumor x 4 Metastatic - N/A Studv Patient Consent Yes 43
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diff --git a/output/text/d0e6307c-ee22-4da5-9564-73e46ef98d4c.txt b/output/text/d0e6307c-ee22-4da5-9564-73e46ef98d4c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..77e992a1627f53aba83bee04886735397dcdfce7
--- /dev/null
+++ b/output/text/d0e6307c-ee22-4da5-9564-73e46ef98d4c.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1es-0-3 #j Cerunomn mpYfnutng dut Nos 85oo/3 C 5U.9 4/7/u h Site: Srent,Nos ormatted Path Report Case ID Subject ID Laterality Date of Procurment BREAST TISSUE CHECKLIST Left, upper outer Specimen type: Lumpectomy quadrant Specimen size: Not specified. Tumor site: Breast Tumor size: 2.1 x 1.8 x 1.4 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinoma Histologic grade: Moderately differentiated :Tumor extent: Not specified :Lymph nodes: 1/17 positive for metastasis (Sentinel 1/17)  Extracapsular invasion of the lymph nodes: No Margins: Uninvolved Nottingham Histologic Score iTubule formation: Moderate 10% to 75% (score=2) Nuclear pleomorphism: Marked variation in size, nucleoli, etc (score=3) Mitotic count (25x): 10 to 20 mitoses per 10 HPF (score=2) Mitotic count (40x): Not specified  Total Nottingham Score: Grade II (moderately differentiated): 6-7 : points Evidence of neo-adiuvant treatment:  Not specified 4/7/y
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diff --git a/output/text/d0e8d5d9-6297-4999-8359-7d8a8fab5561.txt b/output/text/d0e8d5d9-6297-4999-8359-7d8a8fab5561.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4eb03e60a7cb50117087b4b1db81f5036d26b46c
--- /dev/null
+++ b/output/text/d0e8d5d9-6297-4999-8359-7d8a8fab5561.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Sample ID #: Diagnosis: Resectate of the colon (sigmoid colon) with tumor-free oral and aboral resection margins. and under inclusion of an ulcerated, moderately differentiated adenocarcinoma with infiltration of the perimuscular fatty tissue and without regional lymph node metastases. (G2, pT3 L0 V0 R0 pN0 0/55). 1cs-0-3 hidancuci omr, NOs 8146/3 Sit: Sigmoid colon c18.7 p 3/30/u UUID: 28B20E9A-DFF6-400D-91FE-05285D277AC6 'Redacted
\ No newline at end of file
diff --git a/output/text/d0f03002-4b46-4d8d-8147-e832ee902ddd.txt b/output/text/d0f03002-4b46-4d8d-8147-e832ee902ddd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..70fce2f2ac98e9baf0ba05f36fb70926f9b0282c
--- /dev/null
+++ b/output/text/d0f03002-4b46-4d8d-8147-e832ee902ddd.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+LcD-6-3 Lrcmoma, ew^otheliel J6S 8l20/3 path Pathology Report:. CECF Pesterirr woll oFbladde Cb74 t) u/sl13 Surgical Pathology Report FINAL PATHOLOGIC DIAGNOSIS A. Left pelvic lymph nodes; dissection: - Four lymph nodes, no tumor present (0/4) B. Right pelvic lymph nodes; dissection: - Metastatic prostate adenocarcinoma in one of four lymph nodes (1/4). (See comment). - No extranodal extension present. C. Bladder, prostate, seminal vesicles, vas deferens; cystoprostatectomy: - Urothelial carcinoma of the urinary bladder, high grade, invasive into muscularis propria. - Urothelial carcinoma in situ involving surface urothelium and von Brunn's. nests. - Margins of resection (soft tissue, urethra, right and left ureter), no tumor.. present. - Urinary bladder wall with ulceration, necrosis and foreign body giant cell. reaction consistent with previous resection site - Extensive cystitis cystica.. - See pathologic parameters. - Prostatic adenocarcinoma, Gleason score 7 (4+3), with a small component of Gleason grade 5. - Extraprostatic extension present. - Margins of resection positive for carcinoma. UUID:491E768C-1E7C-4461-BFF7-BA846758839F Redacted - Seminal vesicles and vasa deferentia, no tumor present TCGA-FD-A62P-01A-PR - High grade prostatic intraepithelial neoplasia (PIN). - See pathologic parameters. D. Left distal ureter stitch; resection: - Segment of ureter, no tumor present. Urothelial Carcinoma Pathologic Parameters 1. Tumor type: Flat urothelial carcinoma 2. Grade of tumor: High grade 3. Depth of invasion: Muscularis propria 4. Tumor distribution: Multifocal 3 x 2.7 cm the largest size. Right lateral wall. Anterior wall
+
+--- Page 2 ---
+Posterior wall 5. Ureteral margins: Negative 6. Distal urethral margin: Negative 7. Soft tissue margin or serosa: Negative 8. Lymph nodes: Eight lymph nodes, no urothelial carcinoma present (0/8). 9. pTNM: pT2bN0 Effective January 1, 2010 this Checklist utilizes the 7th edition TNM staging system for Bladder of the American Joint Committee on Cancer (AJCC) and the International Union Against Cancer (UICC) Radical Prostatectomy Pathologic Parameters 1. Gleason Score: 7 (4+3) with a small component of Gleason grade 5 2. Perineural Invasion: Present 3. Tumor Location: Peripheral zone - Right and left, Transition zone. 4. Tumor Volume Estimate: 60% 5. High-grade P.I.N.: Multifocal 6. Seminal Vesicles: Negative 7. Extraprostatic extension: Present 8. Peripheral Margin: Negative 9. Distal (apical) Margin: Positive 10. Proximal (basilar) Margin: N/A 11. Regional Lymph Nodes (right and left): Metastatic prostate adenocarcinoma in. one of eight lymph nodes (1/8) 12. pTNM: pT3aN0 Effective January 1, 2010 this Checklist utilizes the 7th edition TNM staging. system for prostatectomy of the American Joint Committee on Cancer (AJCC) and the International Union Against Cancer (UICC).. Comment Part B: The metastatic carcinoma is represented by a single gland that is positive for Cam5.2. Immunohistochemical stain PSA is non-contributory due to. the absence of the malignant gland on a section submitted for. . immunohistochemistry. Interpretation performed by the Attending Pathologist and reviewed with the.
+
+--- Page 3 ---
+Clinical History: The patient is a.  year-old male with bladder cancer undergoing cystectomy.. Specimens Received: A: Left pelvic lymph nodes B: Right pelvic lymph nodes C: Bladder, prostate, seminal vesicles, vas deferens D: Left distal ureter stitch Gross Description: The specimens are received in four containers each labeled with the patient's name and medical record number.. A. The first container is additionally identified as, "left pelvic lymph. nodes". Received fresh and placed in formalin is an aggregate of lobulated yellow fibroadipose tissue measuring 7.2 x 5.4 x 1.3 cm. The specimen is dissected for lymph node candidates. 5 lymph node candidates are identified measuring 0.5-4.5 cm in greatest dimension. The lymph node candidates are entirely submitted as follows: A1: 2 lymph node candidates A2: One lymph node candidate, bisected A3-A4: One lymph node candidate, sectioned. A5-A8: One lymph node candidate, sectioned. B. The second container is additionally identified as, "right pelvic lymph nodes". Received fresh and placed in formalin is an aggregate of lobulated yellow fibroadipose tissue measuring 7.9 x 7.1 x 1.6 cm. The specimen is dissected for lymph node candidates. 10 lymph node candidates are identified. measuring 0.4-7.5 cm in greatest dimension. The lymph node candidates are. entirely submitted as follows: B1: 4 lymph node candidates B2: 3 lymph node candidates B3: One lymph node candidate, bisected. B4-B5: One lymph node candidate, sectioned B6-B8: One lymph node candidate, sectioned C. The third container is additionally identified as, "3. Bladder, prostate, seminal vesicles, vas deferens ". Received fresh and placed in formalin is a 514.6 g, 20.5 x 11 x 5 cm cystoprostatectomy specimen. The bladder is 8.5 x 8.5 x 5 cm. The right ureteral stump is 4.5 x 0.5 cm and the left ureteral stump is 3 x 0.4 cm. The prostate is 6.3 x 4.8 x 4.8 cm. The right seminal vesicle is 4.3 x 2.3 x 0.9 cm and the right vas deferens is 11.8 x 0.4 cm. The left seminal vesicle is 4.3 x 2.4 x 1 cm and the left vas deferens is 6.5 x 0.5 cm. There are 2 additional detached segments of vas deferens measuring 3.8 x 0.4 cm and 9.8 x
+
+--- Page 4 ---
+0.3 cm. The right half of the prostate and bladder is inked blue and the left half is inked black. The bladder and prostate are opened anteriorly along the urethra. The prostate is surrounded by a thin, intact membranous capsule and sectioning demonstrates rubbery, pink-tan, peri-urethral nodularity and a 3.5 x 1 x 1 cm area of firm, tan-white induration along the posterior aspect bilaterally. The seminal vesicles contain dilated cystic spaces filled with. tan, gelatinous material. The opened bladder reveals a 3 x 2.7 cm ulceration located in the right posterior/lateral wall with a 5 x 4.2 cm surrounding area of hemorrhagic mucosa. The remaining bladder mucosa is edematous, wrinkled and pink-tan with a uniform 0.2 cm wall thickness. The bladder is serially. sectioned to reveal tumor grossly extending to a depth of 1.4 cm which is 2.4 cm from the inked blue margin. Bilateral ureteral orifices, adjacent to the trigone, are identified and probe patent. Representative sections are submitted as follows: C1: Distal prostatic urethral margin (apex) C2: Right and left ureter resection margin (right side is inked blue) C3-C5: Prostate apex, shaved and serially sectioned C6-C9: Representative right lobe of prostate from apex to base C10-C13: Representative left lobe of prostate submitted from apex to base C14: Right seminal vesicle and vas deferens. C15: Left seminal vesicle and vas deferens. C16: Uninvolved bladder mucosa, posterior wall C17: Uninvolved bladder mucosa, left lateral wall C18: Hemorrhagic mucosa, dome. C19: Uninvolved bladder mucosa, anterior wall C20-C30: Bladder mass/Ulceration (entirely submitted) with the deepest area of invasion in cassette C20 (with inked margin deep to the area of invasion in cassette C21). D. The fourth container is additionally identified as, "left distal ureter stitch on non-margin side". Received fresh and placed in formalin is a rubbery white-tan tubular structure measuring 0.9 cm in length and 0.6 cm in diameter. There is a stitch designating the non-margin side. The margin side is shaved and submitted in D1. lw 4ls[13
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diff --git a/output/text/d0faa7b1-b8ef-4439-aba6-ef0c6fc42635.txt b/output/text/d0faa7b1-b8ef-4439-aba6-ef0c6fc42635.txt
new file mode 100644
index 0000000000000000000000000000000000000000..87d3d78805289b63fca241f2f3d7b212556e5326
--- /dev/null
+++ b/output/text/d0faa7b1-b8ef-4439-aba6-ef0c6fc42635.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis: This is a partial resection sample of the colon (transverse colon) with a moderately to poorly. differentiated adenocarcinoma with a histopathological differentiation grade G2-3, with erosions of the inner tumor surface, with peritumorous chronic recurrent secondary inflammation with an acute inflammatory flare, with carcinomatous lymphangitis, with tumor infiltration of the colon wall layers as far as the tunica muscularis, with moderate chronic lymphadenitis of the tumor-free lymph nodes (0/15) and with tumor-free overview slices from all other parts of the resection material described. According to the section preparations available, the tumor spread of the colon carcinoma correspond to the tumor stage pT2, pN0 (015), Mx, L1, RO. Tumor classification: ICDO-DA-M 8140/3, G2-3 10+
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diff --git a/output/text/d1189aaa-eccf-4149-99f5-41936e693546.txt b/output/text/d1189aaa-eccf-4149-99f5-41936e693546.txt
new file mode 100644
index 0000000000000000000000000000000000000000..451900b07f63155127c26daa050b13c4dd1a009f
--- /dev/null
+++ b/output/text/d1189aaa-eccf-4149-99f5-41936e693546.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+/c0-0-3 Carcuioma,nifilt^aHmg duchI, Nos 8500f3 Site: Brst,cmul C50r1 1/21/1 fnton Site: Busot,nos c50.9 CQCF Diagnosis: 1. Ablated breast sample with a bifocal poorly differentiated invasive ductal. carcinoma (first tumor is poorly differentiated with a tumor diameter of 2.3 cm and a distance from the resection margins of 2.2 cm cranially, 2.5 cm dorsally, 3 cm. Iaterally and caudally, and 5 cm medially; the second tumor is moderately. differentiated, measuring 2 cm, with a distance from the resection margins of less. than 0.1 cm dorsally, 0.2 cm caudally, 1.5 cm laterally, 3.5 cm cranially, and 7 cm medially) with focal intraductal components.. In conjunction with the preliminary finding, this gives rise to the following tumor classification: NOS, G II, pT2N2aL1V0R0. Redacted UUID:3E967C4F-B916-4A80-A9A1-ASE94F02322C
\ No newline at end of file
diff --git a/output/text/d150aa4f-c5f6-492d-b46a-7647d7f74979.txt b/output/text/d150aa4f-c5f6-492d-b46a-7647d7f74979.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e23cfd6b34819d07466711fe89f6af6c614beec5
--- /dev/null
+++ b/output/text/d150aa4f-c5f6-492d-b46a-7647d7f74979.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+1cs-0-3 Cnrunvmo,mfiltngtimg cuctd,Nos 8500/3 S,H: brsst,nos c50.9 3/" page 1 / 2 Department of Cancer Pathology. copy No. Date: Examination: Histopathological examination Internal invoice No. Cost of diagnostic procedure Examination No.: Patient: xxx PESEL: XXX Age. Gender: F Material: 1. Multiple organ resection - right breast and axillary tissue Unit in charge:  Physician in charge: Material collected on: Material received on: Expected time of examination: up to 8 working days Clinical diagnosis: Cancer of the right breast. Examination performed on: Results of immunohistochemical examination: Estrogen receptors found in over 75% of neoplastic cell nuclei. Progesterone receptors found in 10-75% of neoplastic cell nuclei. HER2 protein stained with HercepTestTM by DAKO. Score = 2+, FISH verification recommended.- Compliance validated by: Examination performed or Macroscopic description: Left breast sized 19,5 x 12 x 4 cm removed along with axillary tissues sized 6 x 5 x 3 cm and a 15.5 x 4 cm skin flap. Tumour sized 3.0 x 2.1 x 1.3 cm on the boundary of outer quadrants, 5.0 cm from the iower boundary, 0.1 cm from the base and 0.5 cm from the skin. UUID: 27376503-A55C-4905-A885-632440EFCED2 TCGA-D8-A13B-01A-PR Redacted
+
+--- Page 2 ---
+Microscopic description: Carcinoma invasivum - NHG2 (3 + 2 + 1/0 mitoses/10 HPF, visual area diameter 0.55 mm). Foci of carcinoma ductale in situ Dcis found within and outside the tumour (solid and cribrate type with medium nuclear atypia, comedo necrosis and calcifications, 10% of the tumour). Additionally, lesions of the type carcinoma lobulare in situ (LCIS). Mamilla sine laesionibus. Glandular tissue showing lesions of the type mastopathia fibrosa et cystica, hyperplasia ductalis simplex (UDh), adenosis sclerosans, calcifications, columnar cell changes CCC). AXILLARY LYMPH NODES Metastases carcinomatosae in lymphonodis No I/VIII. Infiltratio capsulae lymphonodi et telae perinodalis. Preliminary result: Carcinoma ductale invasivum et ductale in situ lobulare in situ (Lcis). Metastases carcinomatosae in lymphonodo axillae (NHG2, pT2, pN1a). Tompliance validated by: page 2 / 2 PEseL: XXX Gender: F Patient: xxx Examination performed on: Results of immunohistochemical examination: RESULT OF HER2/neu GENE AMPLIFICATION with the FISH method by Path Vysion HER2 DNA Probe Kit FINAL RESULT: HER-2 GENE AMPLIFICATION NOT FOUND Compliance validated by: Examination performed on: - Histopathological diagnosis: Carcinoma ductale invasivum et ductale in situ. invasive ductal carcinoma and ductal carcinoma in situ.. Metastases carcinomatosae in lymphono axillae (No 1/vill). Cancer metastases in axillary lymph nodes (No I/V!l) (NHG2, pT2, pN1a) Immunophenotype: E-cadherin+, CK7- Compliance validated by: :
\ No newline at end of file
diff --git a/output/text/d1944d41-2306-4dbd-9008-6c083184c695.txt b/output/text/d1944d41-2306-4dbd-9008-6c083184c695.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8c9aae3756bd94c1b090d58f1b7fc88021f75de3
--- /dev/null
+++ b/output/text/d1944d41-2306-4dbd-9008-6c083184c695.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TCGA-DD-AAVQ-01A-PR Redacted DIAGNOSIS: Liver. S6. segmentectomy: Hepatocellular carcinoma. S6 1) Post-chemoembolization status: absent 2) Size of tumor: 3.0x3.0x2.2cm 3) Gross type: multinodular cont luent type 4) Satellite nodule: absent 5) Histologic tyoe: microtrabecuial. racrotrabecu'ar and so!id 6) Cell type: cirrhotominetic and ciear 7) Edmondson and Steiner s histologic grade:. The worst differentiation: 3 The major ditierentiat ion: 2 8) Fatty change: present (1%) 9) Hemorrhage/pel iosis: prosont (1%). 10) Tumor neciosis: absent 11) Vasculai invasion(microscopic): absent 12) Capsule tormat ion: complete 13) Infiltration of capsule: absent 14) Septal formation: piesen! 15) Involvenent of a major branch of the portal vein: absent 16) Involvement of a major branch of the nepatic vein: absent 17) Bile duct invasion: absent 18) Serosal invasion: absent 19) Surgical margin: negative (satety margin: 2.1cm) 20) Intranepatic metastasis: absent 21) Mult icentr ic occurrence: absent 22),Pathologic stage: AJCc (pT1). (pT2) 23) Related biopsy: none 24) Additional patnologic findings Lc0 0r 3 a) Cirrhosis: present. active b) Dysplasia: absent 8170/3 Sxtt ouier Caa.O QJ 4/aQ)1y w z4
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diff --git a/output/text/d1b33537-ee1c-40be-93a9-d9f442e52d42.txt b/output/text/d1b33537-ee1c-40be-93a9-d9f442e52d42.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3ae77c728c49d83ca2f107a4ea7e53e00f9535ea
--- /dev/null
+++ b/output/text/d1b33537-ee1c-40be-93a9-d9f442e52d42.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+1000 3 Date of surgery : Muorcm. spithlpik Rpsnolle ox00 rmiysL S77013 LE *Crliary lesdly Ci9.4 Left eye enucleation. 09.4 Macroscopye The eye ball mesures 25 mm and presents a posterior segment of optic nerves. measuring 2 mm. At the section, the tumor measures 19 mm main line. Samples have been frozen for genetic studies then the piece has been fixed and included entirely. Su puih distrpency furn for jpitheliril anl  Microcopy Spndle eel nxhiv The tumor observed macroscopically corresponds to an uveal melanoma, mainly composed of epithelioid cells (80%). The tumor cells are large in size and present a vesicular nucleus with mild atypia. The cells are often loaded with melanin. The mitotic index is low (4 mitoses per 10 HPF). The tumor is developed on the temporal side of the eye. At the anterior part, the tumor infiltrates the lateral part of the iris and the ciliary body. At the posterior part. the tumor is close to the optic foramen. However, the optic nerve on its entire course and its cut end are free of tumor, as well as the meningeal sheets. The sclera is also. free and there is no tumor endovascular embolism.. Conclusion UUID:04475A61-A4E9-482C - B088-488852636AE3 CGA-V4-A9E0-01A-PR Redacted Uveal melanoma of the left eye. Epithelioid cells predominant.. Tumor size: 19 mm. Low mitotic index.. Invasion of the periphery of the iris and of the ciliary body. No scleral or extrascleral involvement The optic nerve on its entire course, its cut end and the meningeal sheets are free 211813
+
+--- Page 2 ---
+TCGA Pathologic Diagnosis Discrepancy Form. V4.00 Instructions: The TCGA Pathologic Diagnosis Discrepancy Form should be completed when the pathologic diagnosis documented on the initial pathology report for a case submitted for TCGA is inconsistent with the diagnosis provided on the Case Quality Contro! Form completed for the submitted case. Tissue Source Site (TsS): .. _ TSS Identifier:  Tss Unique Patient Identifier:. Completed By (Interviewer Name on OpenClinica). .. Completed Date: -- Diagnosis Information Data Element Entry Alternatives Working Instructions. 80% epithelioid cells Provide the diagnosis/ histologic subtype(s) documented on Pathologic Diagnosis the in:tial pathology report for this case. If the histology for  Provided on Initial I this case is mixed, provide all isted subtypes.. 20% spindle cells Pathology Report. Histologic features of 61-90% epithelioid cells.  Provide the histoiogic features selected on the TCGA Case Quality Control Form compieted for th:s case. the sample provided  for TCGA, as reflected 1-30% spindle cells  on the CQCF. Discrepancy between Pathology Report and Case Quality Control Form  Provide the reason for Provide a reason describing why the diagncsis on the initial.  the discrepancy The section of the frozen sample used for sending  pathology report for this case is not consistent with the  between the pathology to TCGA corresponds to a section of the tumor  diagnosis selected on the TCGA Case Quality Control Form. report and the TCGA  where the epithelioid part is predominant. Case Quality Control Form. The percentages mentioned on the initial  Pathology Report correspond to an average on the whole embedded sections used for establish the Pathology Report Name of Tss Reviewing Provide the name of the pathologist who reviewed this case.  Pathologist or for TCGA. Biorepository Director I acknowledge that the above informatian provided hy my institution is true and correct and has been quality controlled. TSS Reviewing Pathologist or Biorepository Director. Date I acknowledge that the above information provided by ny institution is true and correct and has been quality controlied. The Attending Pathologist or the Departnent Chairman has been informed or is uware of the above discrepancy in diagnoses. Principal Investigator Signature Date
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diff --git a/output/text/d1c92f13-7eaf-489c-8f3e-1409ab83cdaf.txt b/output/text/d1c92f13-7eaf-489c-8f3e-1409ab83cdaf.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c74328823d4f5282f87096f1e752f4c4ca8c620d
--- /dev/null
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+JCs-0-3 Carcinonn, nfiItrating cluctal, N05 8500f3 Site: brust nus c5o.9 1/ay/u h FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 UUID:24042292-B875-4FAF-8C3A-9834414C3A01 Redacted PATHOLOGY REPORT Patient: Specimen #: FMP/SSN: DOb/Age/Sex: Race: WHITE Taken: Location: Received: Physician(s) : Reported: SPECIMEN: A: SENTINEL LYMPH NODE #1 B: SENTINEL LYMPH NODE #2 C: LEFT BREAST TISSUE FINAL DIAGNOSIS: A. SENTINEL LYMPH NODE #1, LEFT AXILLA, EXCISION: TWO LYMPH NODES, NEGATIVE FOR METASTATIC CARCINOMA BY HEMATOXYLIN AND EOSIN AND IMMUNOHISTOCHEMICAL STAINING. B. SENTINEL LYMPH NODE #2, LEFT AXILLA, EXCISION: ONE LYMPH NODE, NEGATIVE FOR METASTATIC CARCINOMA BY HEMOTOXYLIN AND EOSIN AND IMMUNOHISTOCHEMICAL STAINING. BREAST, LEFT, EXCISIONAL BIOPSY: POORLY-DIFFERENTIATED ADENOCARCINOMA CONSISTENT WITH INFILTRATING DUCTAL CARCINOMA, HIGH GRADE (SEE COMMENT). TUMOR SIZE = 2.2 CM. THE TUMOR IS ONE CENTIMETER FROM THE SUPERIOR POSTERIOR AND SUPERIOR ANTERIOR MARGINS OF RESECTION. BIOPSY SITE CHANGES. FIBROCYSTIC CHANGES. COMMENT : This tumor was graded using the modified Bloom and Richardson scheme with a score as follows: mitoses = 3, tubules = 3, nuclei - 3; for a total score of 9/9, high grade. No in situ carcinoma is identified. ** Report Electronically Signed Out * CLINICAL DIAGNOSIS AND HISTORY:S -year-old white female with left infiltrating ductal carcinoma of breast. Page 1 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
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+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974S SURGICAL PATHOLOGY REPORT Patient: Specimen #: PRE-OPERATIVE DIAGNOSIS: Left breast cancer.. POST-OPERATIVE DIAGNOSIS: Left breast cancer.. GROSS DESCRIPTION: A. The snerimen is received in formalin, labeled with the patient's name, is designated as "SENTINEL LYMPH NODE #1". It consists of~multiple fragments of pink to yellow/tan, irregularly shaped tissue, which measure 2.5 x 2.0 x i.0 cm in loose aggregate. The specimen is submitted entirely. 1cF R. The snecimen is received fresh, labeled with the patient's name, and is designated as "SENTINEL LYMPH NODE #2". It consists of a 3.5 x 2.5 x 1.3 cm piece of fatty tissue containing a 2.5 x 1.3 x 1.2 cm lymph node. The node is bisected, revealing extensive fat infiltration. One half of the node is submitted for Cbcp protocol; the remaining half is submitted for paraffin section in cassette B2. 2CF C. The snecimen is received fresh, labeled with the patient's name,  and is designated "LEFT BREAST TISSUE - ONE STITCH MEDIAL, TWO STITCHES SUPERIOR, THREE STITCHES ANTERIOR". 210 gm portion of fatty tissue,which measures 11.5 x 8.5 x 2.7 cm. The It consists of a specimen is oriented with sutures (long single medial, two stitches superior, three stitches anterior). Ink code: blue superior posterior, orange, superior anterior, black inferior posterior, green inferior anterior. ~Sectioning reveals a well circumscribed, slightly lobulated tan tumor in the lateral portion of the specimen, measuring 2.2~x 1.8 x 1.5 cm. On cut section, the tumor has a centrally placed hemorrhage filled cavity, consistent with prior biopsy. The tumor is at least 1.0 cm from the near margin (black, orange). " The remaining tissue is predominantly fatty with a 1.0 cm area of fibrous tissue punctuated with yellow flecks about 3.0 cm medial to the tissue abutting the green inked margin. Multiple sections are submitted for cBcp protocol with matching paraffin sections as follows:. C1: grossly normal fibrofaty tissue, approximately 5.0 cm medial to tumor. c2: fibrous area with yellow flecks.. c3: tumor. C4: tumor. Additional sections are submitted. c5 and c6: lateral margin.. Page 2 Continued on Next Page. FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
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+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION (continued) : c7: section adjacent to c4. c8 and c9: weli defined mass in section medial to section containing C4 and c7. c10-c15: fibrous areas submitted lateral to medial. c16 and c17: medial margin. 17cr OUALEDTO Page 3 End of Report FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
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diff --git a/output/text/d1d87fc7-6e79-47de-b942-4958bebd131e.txt b/output/text/d1d87fc7-6e79-47de-b942-4958bebd131e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..36d1efbb8350534ebbebb23ebff6bc276adb700c
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+Examination: Histopathological examinatior Material: Multiple organ resection -- segment of the large intestine. TCGA-D5-5537 Unit in charge: Central Qperating Theatre Physician in charge:. Material collected oni  Material received on: Expected time of examination: up to Clinical diagnosis: Cancer of the large intestine  Examination performed or. Macroscopic description: 19.9 cm length of the large intestine, with periintestinal tissue sized 25 x 13 x 3cm, 8 cm segment of the small intestine, and 7 cm appendix.. Cauliflower-shaped tumour in the intestinal mucosa, sized 4.7 x 9.3 x 1.2 cm.. The lesion surrounds 100% of the intestine circumference, 9.2 cm from the proximal cut end, 12.2 cm from the distal cut end, and 1.2 cm from the ileocecal valve.. Tumour accompanied by polyps of up to 1.5 cm. Microscopic description: Adenocarcinoma tubuloapapillare part im mucinosum (G3).. Infiltratio carcinomatosa profunda tunicae muscularis propriae et telae adiposae pericolicae.. Intestine ends free of neoplastic lesions. Off tumour: Adenomata tubulopapillaria cum dysplasia gradus mediocris ad maiorem. Lymphonodulitis reactiva (No VlI)..  Processus vermicularis sine laesionibus. Histopathological diagnosis:e Adenocarcinoma tubulopapillare partim mucinosum coli.. (G3; DukesB; Astler-CollerB2; pT3; pNO). Adenomata rubulopapillaria cum dysplasia gradus mediocris ad maiorem (high grade)..
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diff --git a/output/text/d20d651a-3d77-484c-a9b3-525124a33d2c.txt b/output/text/d20d651a-3d77-484c-a9b3-525124a33d2c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ce028894c689c442669347707d554fdf348fe1bf
--- /dev/null
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+
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+ UUID:1D4CA1BA-B534-4CEA-ABA5-EF9B31694204 TCGA-A2-A25C-01A-PR Redacted Specimen: Received: Status: Req#y Spec Type: SURGICAL P Suba Dr: HEHATE 1cs-0-3 Carcinona,infiP+nahxg oluct,Nos 85ocf3 LEFT BREAST CANCER INVASIVE Sitx : brst, Nos c50.9 DATE: DOCTOR(s) : PROCSDURE: SANTNAESNODERX/SAMRLR MASTROT A. LT BREAST SIMPLE MASTECTOMYS B. LT SENTINEL NODE #1 C. LT SENTINEL NODE #2 RECEIVED IN 3 PARTS. PART A RECEIVED LABELED SIMPLE LEFT BREAST MASTECTOMY STITCH AT 12 O'CLOCK, IS A SIMPLE MASTECTOMY SPECIMENS MEASURING 17.5 X 16 X 2.8 CM.  THE NIPPLE IS UNREMARKABLE WITHIN A 9 X 2.5-CM SKIN ELLIPSE.  ADDITIONALLY WITHIN THE CONTAINER ARE 2 IRREGULARS FRAGMENTS OF FATTY TISSUE WITH NO PALPABLE MASSES TOGETHER MEASURING 4.5 X 3 X 0.5 CM.  THE SUPERFICIAL ASPECT IS MARKED WITH BLUE INK, THE DEEPS WITH BLACK.  SECTIONING REVEALS 2 DISCRETE GRAY FIBROUS NODULES; THE MOST LATERAL IS AT 3 O'CLOCK MEASURING 1.5 X 1.1 X 1.5 CM. ADJACENT TO THIS SEPARATED BY 1.5 CM IN THE 6:30 AREA IS A MASS WITH A COIL CLIP MEASURING 2.2 X 1.8 X 2.1 CM. THESE ARE BOTH 0.5 CM FROM THE DEEP MARGIN. CENTRALLY, THE BREAST HAS DENSE TAN FIBROUS TISSUE, BUT THE PERIMETER OF THE SPECIMEN AND THE TISSUE ADJACENT TO THE DEEP MARGIN IS YELLOW FATTY TISSUE.  THE 3 O'CLOCK LESION IS O.7 CM FROM THE SUPERFICIAL MARGIN.  THE 6 O'CLOCK LESION EXTENDS TO WITHIN O.6 CM OF THE SUPERFICIAL MARGIN. SECTIONS ARE SUBMITTED AS FOLLOWS: A1--NIPPLE; A2--TISSUE BETWEEN THE TWO LESIONS; A3--3 O'CLOCK LESION TO INCLUDE DEEP MARGIN; A4--3 O'CLOCK LESION TO INCLUDE SUPERFICIAL MARGIN; A5 AND 6--FULL CROSS-SECTION OF 6 O'CLOCK LESION TO INCLUDE THE DEEP AND SUPERFICIAL MARGIN, RESPECTIVELY; A7--6 O'CLOCK LESION; A8--UPPER OUTER QUADRANT; A9--UPPER INNER QUADRANT; A10--LOWER INNER QUADRANT; A11--LOWER OUTER QUADRANT. TISSUE FROM EACH LESION IS SUBMITTED PER PROTOCOL.S PART B  RECEIVED LABELED LEFT SENTINEL NODE #1 HOT AND BLUE, IS AN OVOID FRAGMENT OF YELLOW-RED SOFT TISSUE MRASURING 1.7 X 1.0 X 0.9 CM. SECTIONING REVEALS A GROSSLY UNREMARKABLE 1.3-CM LYMPH NODE WITH CENTRAL FAT REPLACEMENT AND BLUE COLORATION. THIS IS SUBMITTED LABELED B, BISECTED. PART C RECEIVED LABELED LEFT SENTINEL NODE #2 HOT
+
+--- Page 2 ---
+Patiantr Specimen: Received: Status: Req# Spec Typ*: SURGICAL P Subm Dr: (Continued) AND BLUS, IS A 1.5 X 0.6 X 0.4-CM OVOID PORTION OF RED-TAN TISSUE. SECTIONING REVEALS THIS TO BE A GROSSLY UNREMARKABLE LYMPH NODE NITH BLUE COLORATION SUBMITTED LABELED C, BISECTED. PROCEDURES: 88307/3, IMMUNOPEROXIDAS/2, A BLK/11, BBX X6, CBX X6 PART A /LEFT, BREAST, SIMPLE MASTECTOMY: 1DC z|2]z 1. MODERATELY DIFFERENTIATED INFILTRATING DUCT CARCINOMA, NUCLEAR GRADE II/III, MODERATE MITOTIC INDEX AND TUBULE FORMATION 2, WITH A TOTAL TYPES, NUCLEAR GRADE II WITH LOW MITOTIC INDEX, ARE SEEN AT THE Crib PERIPHERY OF THE TUMOR.S sou 2. A 1.5-CM TUMOR IS IDENTIFIED IN THE 3 O'CLOCK LOCATION AND A 2.2-CM mustifocal LESION IS IDENTIFIED IN THE 6 O'CLOCK PORTION WHICH ARE SEPARATED BY AT LEAST 1.5 CM OF BENIGN BREAST TISSUE. I.Scm apa Z.2 cm { 1 Scm} 3. THE MARGINS OF EXCISION, NIPPLE SKIN AND RANDOM SECTIONS OF REMAINING QUADRANTS ARE FREE OF TUMOR.S +Lv1 LYMPHOVASCULAR INVASION IS IDENTIFIED. 4. BIOPSY CHANGES ARE PRESENT. Bx 5. PART B LEFT AXILLA, SENTINEL LYMPH NODE BIOPSY #1: METASTATIC BREASTS CARCINOMA IS MULTIFOCALLY IDENTIFIED ON H&E STEP SECTIONS AND CYTOKERATIN STAINS IN 1 LYMPH NODE EXAMINED, THE LARGEST FOCUS OF WHICH MEASURES 3 MMS S N IN GREATEST MICROSCOPIC DIMENSION. NO EVIDENCE OF EXTRANODAL EXTENSION. PART C LEFT AXILLA, SENTINEL LYMPH NODE BIOPSY #2: MULTIFOCAL METASTATIC BREAST CARCINOMA IS IDENTIFIED ON H&E STEP SECTIONS ANDS CYTOKERATIN STAINS IN 1 LYMPH NODE EXAMINED, THE LARGEST FOCUS OF WHICHS MEASURES 2 MM IN GREATEST MICROSCOPIC DIMENSION.S EXTRANODAL EXTENSION ISS NOT PRESZNT
+
+--- Page 3 ---
+atiant: Specimen: Received: Status: Req#: Spec Type: SURGICAL P 8ubm Dx: Her-2/neu: NEGATIVE Score: 1+ Reference Range: Negative 0 - 1+ Equivocal 3+ Positive 3+ Electronically signed by: M.D. See full scanned report for details. Test performed at: 1. SENT TO: 2. REQUESTED BY DR 3. DATB SENT: 4. KETHOD OF TRANSPORTATION: 5. NO. OF BLOCKS: 7. MATERIAL(S) TO BE RETURMED: 14. SPECIKEN SKNT(X/M):  Signed M.D. (prelim.) Electronically signed by: M.D. 127
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diff --git a/output/text/d219b462-7d55-4d52-98ff-62e361b78638.txt b/output/text/d219b462-7d55-4d52-98ff-62e361b78638.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a96fd7806692d4d5b597548022733b0307d1dc6e
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+
+--- Page 1 ---
+UUID: 39549126-83BF-48D6-BDE6-5CE2A48A2E5A TCGA-KM -A7Q6-01A-PR Redacted Patient Results Page 1 of 4 Admit Date: Gender: Male Birth Date: Age: Attending: Admit Protocol: Location: Surgical Pathology (OrderID:) Final Results  Surgical Pathology Final CASE NUMBER: DIAGNOSIS: Icd-0.3 1. Kidney, left, tumor, partial nephrectomy: Renal cell carcinoma,. aremone, neual eeQl chromophobe type; margins of resection are free of tumor (see note). Chomsphsbe type 8317|3 2. Kidney, left, mediai inferior margin, partial nephrectomy: Kidney parenchyma with chronic interstitia! nephritis.. C649 3. Kidney, left, lateral inferior margin, partial nephrectomy:  Kidney parenchyma with chronic interstitial nephritis. ) qI24113 NOTE: Refer to the table below for staging information. KIDNEY: Nephrectomy, Partia! Procedure Partial nephrectomy.  Specimen Laterality Left Tumor Site Not specified Tumor Size Greatest dimension: 6.0 cm. Tumor Focality  Unifocal Macroscopic Extent of Tumor. Tumor limited to kidney Histologic Type Chromophobe renal cell carcinoma Sarcomatoid Features Not identified. Tumor Necrosis Not identified Paner Grade Grade 2: Geographic nuclear crowding (cellular clustering characterized. by high geographic nuclear/cytoplasmic density detectable at 10x objective and some nuclei in direct contact with each other when. assessed at 40x objective) and the presence of nuclear. pleomorphism (size variation of >=3-fold and distinct nuclear. chromatin irregularities (unlike the smudged nudear atypia of. degenerate foci) Confidential Patient Information. Unauthorized disclosure is prohibited by the Federal Privacy Act of 1974. JobID: Requested By: Do not file in Medical Record.
+
+--- Page 2 ---
+Patient Results Page 2 of 4 Admit Protocol: Gender: Male Birth Date: Age: Admit Protocol: Admit Protocol: Location: Surgical Pathology (OrderID: Final Results  Microscopic Tumor Extension Tumor limited to kidney Margins  Margins uninvolved by invasive carcinoma Lymph-Vascular Invasion Not identified Pathologic Staging (pTNM) Primary Tumor (pT) pT1b: Tumor more than 4 cm but not more than 7 cm in greatest  dimension, limited to the kidney. Regional Lymph Nodes (pN) pNX: Regional lymph nodes cannot be assessed No nodes submitted or found Distant Metastasis (pM) Not applicable Pathologic Findings in Nonneoplastic Kidney Significant pathologic alterations Other (specify): Chronic interstitial nephritis Immunoperoxidase and in-situ hybridization tests performed here and used for diagnosis were developed and their performance characteristics determined by the : They have not been cleared or approved by the U.S. Food and Drug Administration. The FDA has also determined that such clearance or approval is not necessary. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLiA) as qualified to perform high complexity clinical laboratory testing. CLINICAL INFORMATION: Brief Clinical History:  year old male with 7 cm left renal mass. Specimen Taken For Protocol: 01 - Yes. Allocate Order to Protocol: PROCEDURE: Pre-Operative Diagnosis: left renal mass. Post-Operative Diagnosis: same. Operative Findings: 7 cm left renal mass. SPECIMENS SUBMITTED: 1. KIDNEY, LEFT, Tumor 2. SOFT TISSUE, NOS, Normal Parenchyma Medial Inferior Margin 3. SOFT TISSUE, NOS, Normal Parenchyma Lateral Inferior Margin GROSS DESCRIPTION: Received fresh are 3 separate specimens labeled Contidential Patient Information. Unauthorized disclosure is prohibited by the Federal Privacy Act ot 1974 JobID: Requested By: Do not file in Medical Record
+
+--- Page 3 ---
+Patient Results Page 3 of 4 Admit Protocol: Gender: Male Birth Date: Age: Admit Protocol: Admit Protocol: Location: Surgical Pathology [OrderID: Final Results with the patient's name, medical record number, and further specified as follows: 1. "Left renal tumor long stitch lateral short stitch inferior' consisting of a partial nephrectomy specimen measuring 8.0 x 6.3 x 6.5 cm. There is an area on the posterior-inferior surface where the margin is disrupted during surgery. The surgeon asks that the tumor from the inferior short stitch be sampled separately as it is a different color from the rest of the tumor. The anterior  surface of the specimen is inked in black and a single incision is made revealing a tar-red friable cut surface. Approximately 50% of tissue from this surface is procured for. Two needle cores are additionally procured for  The remainder of the specimen is placed into formalin and submitted to Pathology for permanent processing. The procurement was documented and performed by . Received in Surgical Pathology on at is a specimen matching the above description. The posterior surface of the specimen is inked in blue. The deep inferior margin is entirely submitted in cassette. The nodule abutting the inferior margin is a golden yellow color. A. representative section of this nodule is submitted in cassette 1B-1C. The dominant nodule appears predominantly necrotic. Scar-like fibrous septae are identified coursing. through this nodule. The dominant nodule measures 6.0 cm in greatest dimension. A representative section of the dominant nodule with respect to the posterior margin is submitted in cassette Additional representative sections of the  main nodule are submitted in cassettes. An additional section of the inferior margin nodule with respect to that margin is submitted in cassette Additional representative sections of the dominant nodule are submitted in cassette . J. The remaining tissue is retumed to  formalin. 2. "Normal parenchyma medial inferior margin". The specimen  consists of a tan-brown soft tissue fragment consistent with renal parenchyma measuring 3.5 x 3.5 x 1.0 cm. The specimen is serially sectioned and representative sections are submitted in cassettes .-D.' The remaining tissue is returned to formalin.. 3. "Normal parenchyma lateral inferior margin" consisting of a  portion of tan-brown soft tissue consistent with renal parenchyma measuring 1.5 x 1.0 x 0.5 cm. It is entirely submitted in cassette 1. Gross Description dictated by Accessioned: Final Report Signed Out: <Resident Signature> Contidential Patient Intonnation. Unauthorized disclosure is prohibited by the Federal Privacy Act ot 1974. JobID: Requested By: Do not file in Medical Record
+
+--- Page 4 ---
+Patient Results Page 4 of 4 Admit Protocol: Gender: Male Birth Date: Age' Admit Protocol: Admit Protocol: Location: Surgical Pathology [OrderID: Final Results <Sign Out Dr. Signature> Date Report Signed: Contidential Patient Intormation. Unauthorized disclosure is prohibited by the Federal Privacy Act of 1974. JobID: Requested By: Do not file in Medical Record
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diff --git a/output/text/d21d2404-dac1-4659-95ba-51e3fcc79016.txt b/output/text/d21d2404-dac1-4659-95ba-51e3fcc79016.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0668b51ddf465c74c88d785f0ad7fa7aff79b30d
--- /dev/null
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+IcD-0-3 Carcinoma, mfiIfratiwy duct, NOS 8500|3 128/10 lu TSS Path d50.y SPECIMENS: CQCF Site. bunst, Nos' C50.9 A. WLE RIGHT BREAST NEEDLE LOCALIZATION B. LEFT SIMPLE MASTECTOMY C. SENTINEL LYMPH NODE #1 LEFT AXILLA UUID:42A1A073-6984-4A66-A998-BE4366E0C89C D. SENTINEL LYMPH NODE #2 LEFT AXILLA TCGA-E2-A14Q-01A-pr Redacted E. SENTINEL LYMPH NODE #3 LEFT AXILLA F. SENTINEL LYMPH NODE #4 LEFT AXILLA G. SENTINEL LYMPH NODE #5 LEFT AXILLA SPECIMEN(S): A. WLE RIGHT BREAST NEEDLE LOCALIZATION B. LEFT SIMPLE MASTECTOMY C. SENTINEL LYMPH NODE #1 LEFT AXILLA D. SENTINEL. LYMPH NODE #2 LEFT AXILLA E. SENTINEL LYMPH NODE #3 LEFT AXILLA F. SENTINEL LYMPH NODE #4 LEFT AXILLA G. SENTINEL LYMPH NODE #5 LEFT AXILLA INTRAOPERATIVE CONSULTATION DIAGNOSIS: TPC, D, E, F, G: Sentinel lymph nodes #1-5, biopsies: No tumor seen. By Drcalled to Dr. ai GROSS DESCRIPTION: A. WLE RIGHT BREAST NEEDLE LOCALIZATION  Received fresh labeled with the patient's name and 'WLE right breast needle localization excision atypical  hyperplasia, single-ant, double lateral, triple superior" is a 28 gm oriented wide iocal excision breast specimen, 6.0 cm from superior to inferior, 4.0 cm from lateral to medial and 2.0 cm from anterior to posterior, with needie Iocalization wire and attached radiograph. The specimen is inked as follows: superior-red, inferior-orange, medial-  green, lateral-yellow, anterior-blue, posterior-black. The specimen is serially sectioned from lateral to medial into 6. slices; slice 1 being most lateral, slice 6 being most medial to reveal multiple gray-white nodular areas, the largest of which measures 0.9 cm in greatest dimension and is located 0.3 cm from the anterior margin. The entire specimen is submitted as follows: A1-A3: lateral margin perpendicular sections taken from superior to inferior slice 1 A4: superior margin slice 2 A5: anterior and posterior margin slice 2 A6: inferior margin slice 2 A7: superior margin slice 3 A8: anterior and deep margin slice 3 A9: inferior margin slice 3 A10: superior margin slice 4 A11: anterior and deep margins slice 4 A12: inferior margin slice 4 A13: superior margin slice 5 A14: anterior and deep margin slice 5 A15: inferior margin slice 5 A16-A17: medial margin perpendicular sections submitted sequentially from superior to inferior slice 6 B. LEFT SIMPLE MASTECTOMY Received fresh labeled with the patient's name and "left simple mastectomy, stitch in axilla" is a 560 g, 21 x 20 x 3 cm mastectomy with an 11 x 5.7 cm skin ellipse with 0.5 cm well healed scar in the lower outer quadrant, 1.5 cm areola, and a 1 cm everted nipple. Inked as follows: superior anterior = blue, inferior anterior = orange, deep margin = black. The specimen is serially sectioned revealing a 2.5 x 2.3 x 1.7 cm well-circumscribed firm tan mass in the upper outer quadrant that is 1.5 cm from the deep margin. A portion of tumor is submitted for tissue procurement. In. the lower outer quadarnt, there is a 1.2 x 1.0 x 0.6 cm hemorrhagic biopsy site, 3.7 cm from the mass. 0.3 cm lateral to the biopsy site is a firm tan nodule, 1.3 cm in diameter. One lymph node is identified near the axillary stitch. Representatively submitted: B1-B6: mass from upper outer quadrant B7-B9: area of biopsy 810: nodule near biopsy site B11: upper inner quadrant B12: upper outer quadrant B13: lower outer quadrant  B14: lower inner quadrant 815-B16: areas of possible calcification from upper outer quadrant B17-B18: nipple B19: possible axillary lymph nodes C. SENTINEL LYMPH NODE #1, LEFT AXILLA
+
+--- Page 2 ---
+Received fresh are 2 tan-pink lymph nodes, 2.0 x 0.9 x 0.9 cm and 0.5 x 0.4 x 0.3 cm. The specimen is serially. sectioned and 2 touch preps are taken. The specimen is submitted entirely as follows:. C1: 1 lymph node C2: 1 lymph node D. SENTINEL LYMPH NODE #2, LEFT AXILLA  Received fresh is a tan-pink iymph node, 1.0 x 0.6 x 0.6 cm. The specimen is serially sectioned and touch preps are taken. Toto D1. E. SENTINEL LYMPH NODE #3, LEFT AXILLA  Received fresh is a tan-pink lymph node, 0.3 x 0.2 x 0.2 cm. The specimen is bisected and touch preps are taken. Toto e1. F. SENTINEL LYMPH NODE #4, LEFT AXILLA Received fresh is a tan-pink lymph node, 1.4 x 0.8 x 0.2 cm. The specimen is serially sectioned and touch preps are taken. Specimen is submitted entirely in cassette F1. G. SENTINEL LYMPH NODE #5, LEFT AXILLA Received fresh is a tan-pink lymph node, 1.8 x 1.0 x 1.0 cm. The specimen is serially sectioned and touch preps are. taken and the specimen is submitted entirely in cassette G1. RESULTS: SUMMARY OF IMMUNOHISTOCHEMISTRY/SPECIAL STAINS Material: Block B4 Population: Tumor Cells Stain/Marker: Resuit: Comment: ECADHERIN Positive The interpretation of the above immunohistochemistry stain or stains is guided by published results in the medical. literature, provided package information from the manufacturer and by internal review of staining performance and. assay validation within the Immunohistochemistry Laboratory. The use of one or more reagents in the above tests is determined by the . They have not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary.. DIAGNOSIS:  A. BREAST, RIGHT, NEEDLE LOCALIZATION WIDE LOCAL EXCISION: - LOBULAR CARCINOMA IN SITU. . SMALL INTRADUCTAL PAPILLOMA, RADIAL SCAR, FLORID USUAL  DUCTAL HYPERPLASIA, COLUMNAR CELL LESIONS, EXTENSIVE  SCLEROSING ADENOSIS, DUCT ECTASIA, AND MICROCALCIFICATIONS. - FOCAL PREVIOUS BIOPSY SITE CHANGES (SEE NOTE).  NOTE: Focal previous biopsy site changes are present in slide A5. B. breast, Left, mastectomy: - INVASIVE DUCTAL CARCINOMA. - SBR GRADE 2. - 2.5 CM IN GREATEST DIMENSION.  - MARGINS, NEGATIVE FOR CARCINOMA. - EXTENSIVE DUCTAL CARCINOMA IN SITU (DCIS), SOLID AND CRIBRIFORM TYPES, NUCLEAR GRADES 2 & 3, WITH COMEDO NECROSIS AND MICROCALCIFICATIONS, INVOLVING LOBULES.  - DCIS IS FOCALLY WITHIN 1 MM OF THE ANTERIOR-SUPERIOR MARGIN.  - DCIS IS PRESENT IN UPPER OUTER AND LOWER OUTER QUADRANTS. - NIPPLE, NEGATIVE FOR CARCINOMA. - ONE LYMPH NODE, NEGATIVE FOR CARCINOMA (0/1). NOTE: Three biopsy sites were identified, associated with the tumor, a fibroadenoma and hemorrhage.. C. SENTINEL LYMPH NODE #1, LEFT AXILLA, BIOPSY: - TWO LYMPH NODES, NEGATIVE FOR CARCINOMA (0/2).
+
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+D. SENTINEL LYMPH NODE #2, LEFT AXILLA, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR CARCINOMA (0/1). E. SENTINEL LYMPH NODE #3, LEFT AXILLA, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR CARCINOMA (0/1) F.  SENTINEL LYMPH NODE #4. LEFT AXILLA, BIOPSy: - MICROMETASTATIC CARCINOMA (1.1 MILLIMETERS) TO ONE LYMPH NODE (1/1) (SEE NOTE) NOTE: The touch prep was reviewed and shows no evidence of carcinoma.. G. SENTINEL LYMPH NODE #5, LEFT AXiLLA, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR CARCINOMA (0/1). SYNOPTIC REPORT - BREASTE Specimen Type: Mastectomy Needle Localization: No Laterality: Left Invasive tumor: Present Multifocality: No WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Tumor size: 2.5cm Tumor site: Upper outer quadrant Margins: Negative Distance from closest margin:e 0.6cm anterior Tubular score: 3 Nuclear grade: 2 Mitotic score: Modified Scarff Bloom Richardson Grade:. 2 Necrosis: Absent Vascular/Lymphatic Invasion: None identified Lymph nodes: Sentinel lymph node only Lymph node status: Positive 1/7 Micrometastases: Yes Non-neoplastic areas:  fibroadenoma, columnar cell change. DCIS present Margins uninvolved by DCIS: DCIS Quantity: Estimate 40% DCIS type: Solid Cribriform DCIS location: Both associated and separate from invasive tumor mass. Nuclear grade: High Necrosis: Present Location of CA++: DCIS Benign epithelium ER/PR/HER2 Results Performed on Case: (mastectomy) ER: Positive PR: Positive HER2: Negative by IHC Pathological staging (pTN): pT 2 N 1mi SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimen: Surgical Excision Block Number: B1 ER: Positive Allred Score: 8 = Proportion score: 5 + Intensity Score 3. PR: Positive Allred Score: 8 = Proportion Score 5 + Intensity Score 3. COMMENT: The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of
+
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+cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring range from O to 8. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2. Methodology: Fixation Type and Length: Tissue was fixed in 10% neutral buffered formalin (I. for no less than 8 and no longer than 24 hours. Antibody and Assay Methodology: Mouse anti-human ER and pr,( Comment: This assay can be used to select invasive breast cancer patients for hormone therapy (1). ER and PR analysis was performed on this case by immunohistochemistry utilizing the ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) antibody provided by Dako, following the manufacturer's instructions listed in the package insert. This assay was not modified, and adherence to all instruction and guidelines were strictly followed. Interpretation of the ER/PR immunohistochemical staining characteristics is guided by published results in the medical literature (1). information provided by the reagent manufacturer and by internal review of staining performance within the Pathology Department.e 1. Harvey JM, et al. Estrogen receptor status by immunohistochemistry is superior to the ligand-binding assay for  predicting response to adjuvant endocrine therapy in breast cancer. J Clin Oncol. 17:1474-1481, 1999 SYNOPTIC REPORT - BREAST HER-2 RESULTS HER2 Status Results, Immunohistochemistry Evaluation Specimen:  Surgical Excision Block Number: B1 Interpretation: NEGATIVEE Intensity: 1+ % Tumor Staining 1% Fish Ordered: No METHODOLOGY Methodology: Fixation Type and Length: Tissue was fixed in 10% neutral buffered formalin (. for no less than 8 and no longer than 24 hours. Antibody and Assay Methodology: Rabbit anti-human HER2 HerceptestTM (FDA-approved test kit), :. Control Stides Examined: External kit-slides. provided by manufacturer (cell lines with high, low and neyative HER2 protein expression), and in-house known HER2 amplified control tissue were evaluated along with the test tissue. These control slides run along side of this patient's sample showed appropriate staining. Adequacy of Specimen: Adequate, well preserved, clear-cut invasive carcinoma identified for HER2 evaluation.. Scoring Criterion and Scoring System: IHC Level of Expression(Score) /Tumor Cell Membrane Staining Pattern. Negative (0)/Absence of Staining  Negative (1+)/Faint Incomplete membrane Staining, >10% of Cells Equivocal (2+)/Weak complete membrane Staining, >10% of Ceils Positive (3+)/Strong complete membrane Staining, >10% of Cells. Equivocal Category for HER2 IHC results: A HER2, 2+ staining result that is interpreted as equivocal may not  indicate gene amplification. A FISH test for HER2 gene amplification will be ordered for all HER2 IHC 2+ resuits. COMMENT  This assay can be used to select invasive breast cancer patients for Trastuzumab (Hereptin) therapy (1,2). Clinical Trials have shown that Trastuzumab substantially increases the likelihood for an objective response and overall  survival for patients with metastatic HER2-positive breast cancer, regardless of whether HER2 tumor status was  determined as IHC 3+ or FiSH positive. Trastuzumab added to adjuvant chemotherapy substantially increase  disease-free survival and decreases the risk of disease recurrence by about 50% for patients with early-stage HER2 protein over-expressed or gene amplified invasive breast cancer (3). HER2 analysis was performed on this case by immunohistochemistry utilizing the FDA approved Dako HercepTest. (TM) test kit following the manufacturer's instructions listed in the package insert. This assay was not modified, and  adherence to all instruction and guidelines were strictly followed. Interpretation of the HER2 immunohistochemical  staining characteristics is guided by published results in the medical literature (4), information provided by the reagent manufacturer and by internal review of staining performance within the Pathology Department. HER2 TEST VALIDATION This HER2 immunohistochemical assay has been validated according to the recently revised recommendations and  guidelines from the NCCN HER2 testing in Breast Cancer Task Force, and the jointly issued recommendations and  guidelines from ASCO and the CAP (5). 80 randomly selected breast cancer samples were tested for HER2 by IHC  as outline above and interpreted as, negative (score 0/1+) equivocal (score 2+) and positive (score 3+) without  knowledge of the previous reported results. These cases were also blindly read using two different FiSH assay as amplified or non-amplified and the. HER2/CEP17 ratios were recorded. After analyzing these results, there was 100% concordance between the IHC  and FISH results for cases that were interpreted as either positive or negative by IHC. 9 of the 80 cases were  interpreted as equivocal by IHC and of these 3/9 (33%) were non-amplified by FiSH and 6/9 (66%) were found to be amplified.  The Pathology Department Immunohistochemistry laboratory takes full responsibility for this tests performance  and has programs in place to regutarly monitor the proficiency and the interpretation of HER2 assays. The
+
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+laboratory also participates in external quality assurance HER2 programs including the CAP proficiency testing program. REFERENCE 1. Carlson RW, Anderson BO, Burstein HJ, et al., NCCN breast cancer clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2005;3:238-289. 2. Carlson RW, Brown E, Burstein HJ, et al., NCCN Task Force Report: adjuvant therapy for breast cancer. J Natl Compr Canc Netw. 2006;4:S1-S26. 3. Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Eng J Med 2005;353(16):1673-84 4. Leong ASy, Formby M, Haffajee Z, et al. Refinement of immunohistologic parameters for Her2/neu scoring. validation by FISH and CiSH. App! Immunohistochem Mol Morphol. 2006;14:384-389. 5. Wolff AC, Hammond EH, Schwartz JN, et al., American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Human Epidermal Growth Factor Recepto 2 Testing in Breast Cancer.. Arch of Path and Lab Med 2007; 131:18-43. PRE-OPERATIVE DIAGNOSIS: Left Breast Cancer, Right Atypical Hyperplasia ADDENDUM: NOTE: Addition to gross description for specimen B -- a representative section of skin is submitted in cassette B20 and microscopically, shows no evidence of carcinoma. ONCOTYPE DX BR' 3T CANCER ASSAY RESULTS: Recurr e Score =: .NCE: Patients with a recurrence score of: 9 in the clinical validation study had an average. CLINICAL EXPF rate of Distant surrence at 10 years of 7% ER Score: Positive 10.8 PR Score: Positive 8.5 Positive ER Score is >= 6.5 Positive PR Score is >= 5.5 Interpretation: See separate report for further information Test performed at: Gross Dictation: Pathologist, Microscopic/Diagnostic Dictauon: Patnoiog Microscopic/Diagnostic Dictation: Patholoqist Finai Review: Pathologist, Final Review: Pathologist. ' Final: Pathologist, Addendum: Pathologist Addendum Final: Pathoiogist,. Addendum: Pathologist, ' Addendum Final: Pathologist
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diff --git a/output/text/d297e1dd-caf8-4910-9ca0-6b8d7187caa4.txt b/output/text/d297e1dd-caf8-4910-9ca0-6b8d7187caa4.txt
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index 0000000000000000000000000000000000000000..5d80b3b61b0f4ce1a8cde002db33da3f2e0eeb28
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+UUID:750A04D5-2521-4E30-AEE6-E79BA25D6CC1 TCGA-DK-A3IN-01A-PR Redacted SURGICAL PATHOLOGY REPORT ( Patient Name: Accession #: Med. Rec. #: Date of Procedure: DOB: (Age:  Location: Date of Receipt: Gender: M Service:  Urology Date of Report: Ref. Physician: Account #: Patient Address: Billing Type: INPATIENT Additional Copy to: Ref. Source: Clinical Diagnosis & History: Bladder carcinoma. HG T2 lesion invaded prostate and obstructing left UO. Specimens Submitted: 1: Prostate (fs) 2: Anterior rectal mass (fs) 3: Right pelvic lymph nodes 4: Left pelvic lymph nodes 5: Bladder, urethra, urachus, prostate, seminal vesicles, peri-vesicle tissue and lymph nodes; cystoprostatectomy 6: Right pelvic lymph nodes 7: Left vas deferens 8: Urethral margin 9: Left distal ureter 10: Right periureteral tissue 11: Right distal ureter large clip on proximal margin DIAGNOSIS: Prostate; biopsy: -Invasive urothelial carcinoma involving fibrous tissue. 2. Anterior rectal mass; biopsy: -Prostatic tissue with acute and chronic inflammation and marked cautery artifact. -No carcinoma seen. Ics-0-3 Right pelvic lymph nodes: Cscoms, nrothliul, N0s F1xo/3 3. Lymph Node Dissection: Path Sih: b1sddiv, N0s C61.9 Benign lymph nodes Number of lymph nodes examined: 5 CWcF: b1addiv, ivxll, lstsrsl cl1.2 /2/7/ 4. Left pelvic lymph nodes: Lymph Node Dissection: Benign lymph nodes Number of lymph nodes examined: 7 UALIFIEG iwj 12/7/ 5. Bladder, urethra, urachus, prostate, seminal vesicles, peri-vesicle tissue and lymph nodes; cystoprostatectomy: a. Tumor Type:  Invasive urothelial carcinoma, NOS Histologic Grade: Page 1 of 7
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT High grade Pattern of growth of the Non-Invasive component:e Papillary and flat Pattern of growth of the Invasive component:. Infiltrating Tumor Multicentricity: Identified Bladder Local Invasion: Perivesical soft tissues Extravesical Tumor Extension: Right ureter involved Left ureter involved Urethra uninvolved Periurethral prostatic ducts involved  Prostatic stroma involved The left seminal vesicle wall and the fibroadipose tissue surrounding the right seminal vesicle are involved.. Vascular Invasion:  Identified Perineural Invasion: Identified Surgical Margins: Tumor present at perivesical soft tissue margin anteriorly Non-Neoplastic Mucosa: Exhibiting chronic cystitis Exhibiting ulceration Prostate: Other Prostatic stroma involved Seminal Vesicles: Other Left seminal vesicle involved Perivesical Lymph Nodes: Not identified The Pathologic Stage is (AJCC 2002): pT3 (Invasion of perivesicle soft tissue) PR2 (Periprostatic or periseminal vesicle soft tissue invasion) tissue invasion). Comment: According to 7th edition of the AJCC Cancer Staing Manual, this tumor would be staged as T4a. Tumor Type: Adenocarcinoma Gleason's Grade: Primary Gleason grade:3 Secondary Gleason grade:3 Total Gleason score:6 Tumor Location: Invoives Right anterior Dominant tumor mass located in: right anterior mid. Vascular Invasion: Not Identified Perineural Invasion: Page 2 of 7
+
+--- Page 3 ---
+SURGICAL PATHOLOGY REPORT Not identified Tumor Multicentricity: Not identifed High Grade Prostatic Intraepithelial Neoplasia: Identified Capsule: Tumor confined to prostate Seminal Vesicles: Not involved Bladder Neck: Not Involved Surgical Margins: Free of tumor Non-Neoplastic Prostate: Exhibits nodular hyperplasia Staging (AJCC 1997): pT2a (confined to the prostate & capsule, involving one lobe). Right pelvic lymph nodes: Lymph Node Dissection: Benign lymph nodes Number of lymph nodes examined: 2. Vas deferens, left;excision: - Benign vasculature and fibroadipose tissue. 8.  Urethral margin;excision: - Benign urethra. 9. Ureter, left distal;excision: - Benign ureter with acute inflammation and reactive atypia. 10. Right periureteral tissue;excision:. - Benign fibroadipose tissue. 11. Ureter, right distal; excision:. - Benign ureter. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. +** Report Electronically Signed Out **** Gross Description: Page 3 of 7 C
+
+--- Page 4 ---
+SURGICAL PATHOLOGY REPORT 1. The specimen is received fresh, labeled "prostate", and consists of a piece of tan soft tissue measuring 2.5 x 1.7 x 0.4 cm. The specimen is entirely submitted for frozen section diagnosis. Summary of sections: FSC - frozen section control 2. The specimen is received fresh, labeled "anterior rectal mass", and consists of muitiple pieces of tan soft tissue ranging from 0.3.  to 1.5 cm in greatest dimension. The larger piece is bisected, and the specimen is entirely submitted for frozen section diagnosis. Summary of sections:. FSC - frozen section control 3. The specimen is received in formalin, labeled "right pelvic lymph node", and consists of multiple pink tan fatty lymph nodes with attached fatty fibrous tissue ranging from 0.2 cm to 2.4 cm in greatest dimension. Cut section reveals that the largest lymph node is. grossly positive. All additional identified lymph nodes are entirely submitted. Summary of sections: GPLN - grossly positive lymph node LN-lymph nodes BLN-bisected lymph nodes 4. The specimen is received in formalin labeled "left pelvic lymph node", and consists of multiple pink tan fatty lymph nodes with  attached fatty fibrous tissue ranging from 0.4 cm to 4.2 cm in greatest dimension. All identified lymph nodes are submitted.. Summary of sections: LN - lymph nodes BLN - bisected lymph nodes LN1 - half of largest lymph node  ADD - remaining half of largest lymph node 5. The specimen is received fresh, labeled "bladder, prostate, urethra, urachus, seminal vesicles and perivesical tissue and lymph nodes". It consists of a bladder with attached prostate and seminal vesicles measuring 17.0 cm from superior to inferior, 11.5 cm. from medial to lateral, and 7.2 cm from anterior to posterior. The bladder measures 7.5 x 6.5 x 3.5 cm and the prostate measures. 4.6 x 4.2 x 4.0 cm. The right half of the bladder and prostate is inked green; the left half of the bladder and prostate is inked blue. The prostatic urethral margin is shaved and submitted en face. The bladder is opened along the anterior midline to reveal a tan-yellow friable papillary centrally necrotic tumor involving predominately the left posterior and left lateral wall extending down the trigone measuring 6.1 x 4.5 x 1.8 cm.  The friable tissue partially occludes the leff ureteral orifice and grossly approaches the right ureteral orifice.  The tumor extends into the prostatic parenchyma and lies 3.6 cm from the prostatic urethral margin. The tumor is sectioned to reveal gross extension through the bladder wall into the perivesical fat. A full face section is taken, bisected, and submitted accordingly. The tumor also approaches the anterior soft tissue margin, and grossly invades the seminal vesicles bilaterally.  There is an additional ulcerated lesion in the dome of bladder that measures 2.2 x 1.8cm and lies 1.8 cm from the trigone, 2.5 cm from the right ureteral orifice, and 3.2 cm from the left ureteral orifice. The remaining bladder mucosa is dusky and. congested. TPs from both ulcerated tumor foci are submitted. Representative sections are submitted for routine processing. Summary of sections: UTHM - urethral margin RUM - right ureter margin LUM - left ureter margin TAM - tumor to anterior soft tissue margin TP - tumor to posterior soft tissue margin TPR - tumor to prostate TU - tumor to prostatic urethra TF - tumor to fat (full face section) TU - tumor to urethra UD - ulcerated defect within the dome RUO - right ureter orifice LUO - left ureter orifice to left ureter (bisected) LU - remaining left ureter Page 4 of 7
+
+--- Page 5 ---
+SURGICAL PATHOLOgy REPORT LP - left posterior wall LA - left anterior wal! RP - right posterior wall RA - right anterior wall TRI-trigone DOM -- dome PU -- prostatic urethra RSV - right seminal vesicle LSV - left seminal vesicle RAP - right apex prostate LAP - left apex prostate RAM - right anterior mid prostate RPM - right posterior mid prostate LAM - left anterior mid prostate LPM - left posterior mid prostate RAB - right anterior base prostate RPB - right posterior base prostate LAB - left anterior base prostate LPB - ieft posterior base prostate 6. The specimen is received fresh, labeled "right pelvic lymph nodes", and consists of one pink tan firm lymph node, which measures 3.5 x 0.4 cm. The lymph node is bisected and entirely submitted. Summary of sections: BLN - lymph node 7. The specimen is received in formalin labeled, "left vas deferens", and consists of a 3.5 x 2.5 x 0.7 cm portion of yellow-tan, Iobulated fibroadipose tissue with two attached, tan-brown, patent luminal structures.  Sectioning reveals rubbery cut surfaces with no gross lesions.Representative sections are submitted. Summary of sections: U -- undesignated 8. The specimen is received in formalin, labeled "urethral margin", and consists of a single irregular portion of brown-tan, focally. hemorrhagic soft tissue measuring 1.5 x 0.9 x 0.6 cm.The specimen is entirely submitted. Summary of sections: U -- undesignated 9. The specimen is received in formalin, labeled "left distal ureter", and consists of a segment of ureter measuring 1.3 x 0.5 x 0.4. cm.The specimen is entirely submitted. Summary of sections: U -- undesignated 10. The specimen is received in formalin, labeled, "right periureteral tissue" and consists of a segment of ureter measuring 1.7 x 1.3 x 0.8 cm.The specimen is entirely submitted. Page 5 of 7
+
+--- Page 6 ---
+SURGICAL PATHOLOgY REPORT Summary of sections: U -- undesignated 11. The specimen is received in formalin labeled, "right distal ureter, large clip on proximal margin", and consists of a segment of  ureter measuring 1.4 x 1 cm with a clip at one end. The clipped end has been designated the margin by the surgeon and is inked  blue. Sectioning reveals a pinpoint lumen.The specimen is entirely submitted. Summary of sections: CE - clipped end ss - serial sections Summary of Sections: Part 1: Prostate (fs) Block Sect. Site PCs 1 FSC 1 Part 2: Anterior rectal mass (fs) Block Sect. Site PCs 1 FSC 5 Part 3: Right pelvic lymph nodes Block Sect. Site PCs 2 ADD 2 3 BLN 3 1 GPLN 1 1 LN 1 Part 4: Left pelvic lymph nodes Block Sect. Site PCs 2 LN 2 4 LN1 4  Part 5:  Bladder, urethra, urachus, prostate, seminal vesicles, peri-vesicle tissue and lymph nodes; cystoprostatectomy Block Sect. Site PCs 6 ADD 7 1 DOME 1 1 LA 1 1 LAB 1 1 LAM 1 LAP 1 1 LP 1 1 LPB 1 LPM 1 1 1 LSV 1 1 LU 1 1 LUm 1 2 LUO 2 1 PU 1 1 RA 1 1 RAB 1 1 RAM 1 Page 6 of 7
+
+--- Page 7 ---
+SURGICAL PATHOLOGY REPORT 1 RAP 1 1 RP 1 RPB 1 RPM 1 RSV 1 RUM 1 1 RUO 1 2 TAM 2 2 TF 2 2 Tp 2 2 TpR 2 1 TRI 1 2 TU 2 2 UD 2 1 UTHm 1 1 VD 1 Part 6:  Right pelvic lymph nodes Block Sect. Site PCs 2 BLN 2 Part 7: Left vas deferens Block Sect. Site PCs 1 U 3 Part 8:  Urethral margin Block Sect. Site PCs 1 U 1 Part 9: Left distal ureter B!ock Sect. Site PCs 1 U 1 Part 10: Right periureteral tissue Block Sect. Site PCs 1 U 1  Part 11: Right distal ureter large clip on proximal margin Block Sect. Site PCs 1 CE 1 1 ss 2 Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 1. Frozen Section Diaanosis: Prostate (fs): Poorly differentiated carcinoma with similar morphologic features to the prior bladder tumor Permanent Diagnosis: Same 2. Frozen Section Diagnosis: Anterior rectal mass (fs): Prostatic tissue with a focus showing marked cautery artifact, cannot further classify on frozen : Permanent Diagnosis: See tinal diagnosis. Page 7 of 7 END OF REPORT
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+IcD-0-3 adunocxicinmn N0s 814of3 Sip: 1ranovuse crbn C18,4 347 Sample ID #: Diagnosis: 1.: Tumor-free lymph node (from the mesenteric root).. 2.: Resectate of the transverse colon with tumor-free oral and aboral resection margins. and under inclusion of a locally advanced, ulcerated, poorly differentiated adenocarcinoma with penetration of all layers of the wall, with infiltration of the perimuscular fatty tissue and the neighboring omentum, with invasion of the stomach wall and without regional lymph node metastases (G3, pT4 L0 V0 R0 pN0 0/45). 3.: Tumor-free spleen with fresh (iatrogenic) defects to the capsule.. As requested, a paraffin block of the material was sent to Prof. for further analyses to exclude or demonstrate the presence of an HNPCC situation. A follow-up report on this will be submitted at a later date.. Follow-up report:. Based on the findings described in the enclosed copy of the consultation report that has now arrived, Prof.. (Pathology, finds no further indications of the. presence of an hereditary predisposition to the spectrum of tumors within the HNPCC / Lynch Syndrome.. UUID:7C26217F-5005-4D0F-9E8A-01E31908AB01 Redacted
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diff --git a/output/text/d2b149dc-be1a-4131-b73c-ad8b4c6c1190.txt b/output/text/d2b149dc-be1a-4131-b73c-ad8b4c6c1190.txt
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index 0000000000000000000000000000000000000000..67d959fad65e667b39a8f61e2217660beaa93407
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+UUID:ED92C74C-5F12-4163-8894-1F538D245189 TCGA-VD-AA8N-01A-PR Redacted Department of Pathology , HISTOPATHOLOGY Surname Lab No Clinical Consultant & Location Forename(s) DOB!Age Sex Unit No Request Date This Copy For: IGD0 3 SPECIMEN RESECTION OF EYE AND EYE APPENDAGES ce miyd $ 77o/3 ENUCLEATED RIGHT EYE Sit  ChcuxoL C i9.3 CLINICAL DETAILS ?L 5k30/14 Right eye choroidal melanoma and exudative retinal detachment. MACROSCOPIC DESCRIPTION A fresh intact right globe. Dimensions: Axial 27.5mm Horizontal 25.5mm Vertical 25mm. Cornea Horizontal 11.25mm Vertical 11.5mm Optic Nerve Fresh On trans-illumination, a large shadow is seen measuring. approximately 2omm ?? on the lateral side. Plane of Section Horizontal Intraocular description: On opening, a large solitary ? shape is seen. Query: Cilio choroidal mass seen. Tumour Size LBD 15mm Height 12mm MICROSCOPY Histologically, the enucleated eye demonstrates a normal. anterior segment with an unremarkable cornea, a deep anterior chamber and open angles. The iris leaves are. unremarkable. The lens shows advanced cataractous changes. ciliary muscle and body. This is bilobed and extends posteriorly into the adjacent choroid. In the central apical. Reported: Pathologist: Electronically Verlfied: '.
+
+--- Page 2 ---
+rinted: Department of Pathology Page 2 of 3 HISTOPATHOLOGY REPORT Tel: Surname Lab No Cllnical Consultant & Location Forename(s) DOB/Age  Sex Unit No Request Date This Copy For: part of the tumour, there is a small area of necrosis. The tumour is associated with disruption of the ciliary body processes and with a detachment of the retina. It is pigmented and consists of a mixture of cells, both epithelioid and spindle cells, with a dominance of the former cell type.' The melanoma cells are immunoreactive for MelanA, cDli7 and Hsp-27 (score 1). The number of mitoses is approx. 21/40 high power fields.. The microvasculature of the melanoma is prominent, and closed loops are present in the tissue planes evaluated. The lymphocytic infiltrate within tumour is minimal. Macrophages are scattered throughout the tumour in a moderate. density.There is no evidence of scleral invasion or of. extraocular growth. The optic nerve is tumour free, and demonstrates mild atrophic changes. The examined vortex veins are free of tumour. FINAL DIAGNOSIS Choroidal melanoma of epithelioid cell type. COMMENT Molecular genetic examination of DNA extracted from the tumour cells will be performed using multiplex-ligation dependent probe amplification (MLpA), looking at chromosomes 1, 3, 6 and 8. A supplementary report will follow as soon as these investigations are complete. MOLECULAR GENETICS In the meantime, molecular genetic analysis of tumour DNA extracted from the fresh uveal melanoma tissue was performed. using the technique termed multiplex ligation-dependent probe amplification (MLpA). These investigations were performed in the The kit p027 from , which examines for gains or. losses in 31 loci on chromosomes 1, 3, . 6 and 8, was used. The DNA concentration was measured using and the Reported: Pathologist: Electronlcally Verified:
+
+--- Page 3 ---
+rinted Department of Pathology Page 3 of 3 HISTOPATHOLOGY REPORT Tel:  Surname Lab No Clinical Consultant & iocation Forename(s) DOB/Age Sex Unit No Request Date This Copy For: quality assessed using multiplex-PCR prior to the MLPA reaction. The DNA concentration was high and of good quality on differing occasions, resulting in similar results. The results of the sequence analysis of the MLpA products is. printed on a separate report. In summary, sequence analysis demonstrated: Normal chromosome 1, monosomy 3, normal chromosome 6 and gains in chromosome 8. Taken together, these molecular data would place the patient. in the high risk group with respect to the development of. metastatic melanoma. Consideration of clinical features of the tumour is, however, also required. Reported: Pathologist: Electronically Verified: j 12/19/13 UALIFIED
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+1Cs-0-3 Carcnoma, nifiltrettny jurgical Patholog ouct, Nos 0 8500/3 Surg Path Sit:brust N0s c5O.9 CLINICAL HISTORY: Bilateral breast tumors. GROSS EXAMINATION: A. "Left breast tumor (long suture lateral, short suture superior)", fresh. Received is a 6 x 2.5 x 1 cm portion of fibroadipose tissue consistent with breast tissue, with orientation sutures provided,. the anterior surface is inked green, and the posterior blue. Specimen is transected to reveal a single firm 1.2 x 1 x 1 cm gray-white tumor which in many areas is relatively well circumscribed but in other areas appears to have an infiltrative border. There is flecks of yellow within the specimen. The neoplasm grossly extends to within 0.3 cm of the closest (anterior) margin of resection. A portion of tumor is submitted to the Tissue Bank for Estrogen and Progesterone receptor analysis. The entire submitted in Blocks Al-A7, with the majority of the tumor in Blocks A2-A4.. B. "Right breast tumor (long suture lateral, short suture superior). Received is a 5 x 4.5 x 2 cm portion of fibroadipose tissue consistent with breast tissue, which is oriented with a long and short suture. The anterior surface is inked blue and the posterior black, and the specimen is transected to reveal a roughly dumb bell shaped 2.0 x 1.0 x 1.0 cm firm, gray-white mass with infiltrative borders. The tumor grossly extends to within 0.3 cm of the closest margin of excision. Tissue has been sent for Estrogen and Progestrone essays. The entire specimen is submitted from anterior to posterior in Block B1 through B8 with the majority of the tumor in Blocks B3-B7.  The anterior margin is in Block Bl and posterior margin in Block B8. DIAGNOSIS: A. BREAST, "LEFT TUMOR," EXCISIONAL BIOPSY: INVASIVE AND INTRADUCTUAL CARCINOMA (1.2 X 1.0 X 1.0 CM), NSABP NUCLEAR GRADE 2, HISTOLOGIC GRADE 2, EXTENDING FOCALLY TO WITHIN 1OO MICRONS OF THE INKED MARGIN OF EXCISION (ANTERIOR A4). INTRADUCTAL CARCINOMA ACCOUNTS FOR LESS THAN 5% OF TOTAL TUMOR VOLUME. VASCULAR INVASION NOT PRESENT. TISSUE SUBMITTED FOR ER/PR. Criterla APOCRINE METAPLASIA PRESENT IN BENIGN BREAST TISSUE. B. BREAST, "RIGHT TUMOR". EXCSIONAL BIOPSY: INVASIVE AND(INTRADUCTAL\CARCINOMA (2.0 X 1.0 X 1.0 CM),) NSABP NUCLEAR GRADE 2, ,-- HISTOLOGIC GRADE 3, EXTENDING FOCALLY TO WITHIN 1OO MICRONS OF THE INKED MARGIN OF EXCISION (POSTERIOR B2,B3,B7). INTRADUCTAL CARCINOMA ACCOUNTS FOR 5% OF TOTAL TUMOR VOLUME. VASCULAR INVASION NOT PRESENT. TISSUE SUBMITTED FOR ER/PR. MICROCALCIFICATIONS AND EPITHELIAL HYPERPLASIA OF THE USUAL TYPE IN BENGIN BREAST TISSUE. Verified by: M.D. (Electronic Sianature) UUID:0F86BB0F-C3F9-43E6-8BDE-90D1DBA298CA TCGA-B6-A0X7-01A-PR Redacted
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diff --git a/output/text/d2e66a2d-5fbd-4e0f-b1e4-013ebd9d7142.txt b/output/text/d2e66a2d-5fbd-4e0f-b1e4-013ebd9d7142.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2c7c8b0a250d413a901cf4e57cacd401bfcf53f2
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Requesting Doctor's information: UUID:6A505565-4298-4D8A-A591-AAB54CF43866 TCGA-OR-A5A-01A-PR Redacted . m  A HISTOPATHOLOGY FOR REVIEW T H : 0 Slides were reviewed as part of a study comparing CGH performed on fresh frozen L tissue in benign and malignant adrenal cortical tumours.. 0 I agree with diagnosis of adrenal cortical carcinoma. G Y Tumour Weight 865 g. tc D-8-3 Weiss criteria: All 9 from 9 Corcinomo, Adveual Csr+cs1 8376l3 Less than 25% clear cells Necrosis Site: Adreual Glard, cor tex C74. D. Diffuse Architecture Venous invasion QtD 11a0)/3  Sinusoidal invasion Capsular invasion High nuclear grade High mitotic rate A Atypical mitosis N FINAL DIAGNOSIS: A Adrenal: Adrenal cortical carcinoma T 0 M REPORTING PATHOLOGIST: (Electronic Signature) 1 c A L p A T H 0 Page 1 of 1 0
+
+--- Page 2 ---
+D.O SEX Specimen : Specs. Multiple Type Exans : Z 2 C5 ES1 IP4 CLINICAL HISIORY Nodule fran anterior duoderum ? met fran adrenal tumour.. 1..  Torted appendix epiploicae transverse colon. Rt adrenocortical" tumour. IVC invasive mass. 3 Addition tunour fram crus of Rt diaphragm. MACROSCDPIC All 1. LABELLED 'NODULE CN FRCNT QF IODENM'. A single 3nm biopSy. embedded in ane block. as "No Examined by frozen section and reported by Dr. evidence of malignancy'. LABELLED 'RIGHT ADREND CORTICAL CANCER'. A large tumOUr weighing 2. 865g and measuring 150 x 100 x 100nm. Ine tumour i3 incanpletely surrounded by fibrous capsules, has been previously opened and nas a. ragged haerrorrhagic, variegated yellow grey nodular cut surface. Blocks: A-C tumour with capsule; D-K representative sections tumour. 3. LARELLeD `IVC INVASIVE MASS'. Two pieces of ragged tissue with an aggregate weight of 21g. They measure 55 x 35 x 3Smm and 50 x 20 x 20m.  They have a ragged yeliow grey cut surface.Representative. sections in four blocks. 4. LABELLED 'ADDITICNAL TUMOUR FRCM CRUS OF DIAPHRAGM'. A in one block. 5.. LABELLED *TORTED APPENDIX EPIPLOICAE OF TRANSVERSE COLON'.A 7 x Smrm. All embedded in one block. continued
+
+--- Page 3 ---
+MICROSODPIC Sections show fibrous tissue in which there is no significant abnormality. 2.  Sections show an encapsulated adrenal tunour comprising cells with large anount of eosinophilic cytoplasm and pleanorphic muclei. forming trabeculae and clustes. There is marked tumour necrosis. Mitoses focally measure up to 18/10 HPF.. Immmoperoxidase studies show staining of the tumour cells for HmB45. inhibin and synaptophysin..  There is no staining for cytokeratin and chramogranin A. The appearances are consistent with an adrenocortical carcincma. 3. Sections show trabeculae of abnormal cells with focal overlying endothelial cells and organising thrombi. The appearances are consistent with adrenocortical carcinoma.  Sectians show trabeculae of aknormal cells invading the fibrous tissue. carcinama. 5.  Sections show nodular fibrous tissue with overlying mesotheliun. The appearances are consistent with organised torted ayperdix epiploicae. OCNCTOSHION 1. Front of duoxdanm - Fibrous nodule.. 2. Right adrenal - Adrenocortical carcinama. 3. IvC - Adrenocortical carcinama. 4. Crus of diaphragn - Adrenocortical carcinama.  Transverse colon - Torted appendix epiploicae. Reported on QUALi
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diff --git a/output/text/d2efb4df-6cc3-436b-879d-89aae4f01070.txt b/output/text/d2efb4df-6cc3-436b-879d-89aae4f01070.txt
new file mode 100644
index 0000000000000000000000000000000000000000..aa241ae9f32cf8a49d900884265c49182e82973f
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+
+--- Page 1 ---
+JUID:5077D8C6-57D2-4C6A-9316-71BE40224195 TCGA-BL-A0C8-01A-PR Redacted 1cs-0 3 camomsj wrrHhcliaL,Nos 812sf3 Sif: bhdd, oome Ck7.1 1w 9/3/y SPECIMEN Bladder tumor CLINICAL NOTES PRE-op DIagnosIs: Bladder cancer per op report in Procedure, partial cystectomy of tumor in dome of the bladder. GROSS DESCRIPTION Received fresh for tissue procurement labeled "bladder tumor" is a 10.5 x 5.5 x 5 cm dusky tan-red to gray-brown mass of tissue. On sectioning, focal areas of soft papilliferous white-pink tissue in keeping with tumor are identified. A portion of the presumptive tumor is submitted for tissue procurement as requested. Received separately within the specimen container is a copious amount of red-brown clot. No anatomic structures are evident. Random representative sections focusing on the apparent tumor are submitted in eight blocks. Rs-8..  RR1-8 additional sections submitted to evaluate for the presence or absence of muscle invasion. MICROSCOPIC DESCRIPTION Microscopic examination reveals extensive high grade urothelial carcinoma with some clear cell differentiation. The tumor is extensively exophytic. Invasion of lamina propria is identified in tissue block 6 and RR3. Muscularis propria is present. And some foreign body giant cell reactions are identiifed in the muscularis propria sections. However, no diagnostic invasive tumor is identified in those sections of muscularis propria. The lack of orientation of the specimen precluded accurate margin evaluation. The exophytic friable nature of the tumor also precluded accurate margin evaluation.. MICROSCOPIC DESCRIPTION 5 DIAGNOSIS A. Bladder tumor, dome of bladder partial cystectomy: Urothelial carcinoma with areas of clear cell differentiation, WHO high grade.. Invasion into lamina propria present.. See microscopic description.. M.D. (Electronic Signature) - End Of Report -
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diff --git a/output/text/d3029de1-eae7-45d4-9f22-c879035b5318.txt b/output/text/d3029de1-eae7-45d4-9f22-c879035b5318.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8b07b1726acab7e97419e4d0b0f9ef8b94bc6f15
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+PREVIOUS DIAGNOSIS INQUIRYS REPORT DATE: PAGE #: SEX: F BIRTHDATE: ADM DATE: OPER DATE: sgD o-3 PROCEDURE: SPDX Cou unma, chyatouslulo. 817013 Adenomatous hyperplasia of endometrium. Squamous metaplasia of cervix. (2) Ovaries and fallopian tubes, excision: tubo-ovarian adhesions. 9w t/a3/13 Follicular cysts. (3) Right interiliac and external iliac lymph nodes, excision: four lymph nodes. all negative for neoplasm. UUID: 8CE97410-9210-4B15-97FE-E61722535975 Code: Service: TCGA-KR-A7K7-01A-PR Redacted FC: 23209 M-72000 M-72420 M-81403 T-82000 OPER DATE: PROCEDURE: SPHSE History with mass in left hepatic lobe. Tissue Submitted: Left lateral segment. Liver. PROCEDURE: SPGD 1. "Left lateral segment of liver" Received in formalin in an extra large container is a 2040 gram the lobe of liver designated left and is 20 x 8 x 10 cm. Extending from the anterior aspect is a protuberant partially encapsulated. massive tesion, 14 x 13 x 10.2 cm. Capsule surrounding the liver segment is tan and focally nodular. The margin of resection is inked blue. Cut surface of. the liver is a tan-brown nodular tissue. It is remarkable for the aforementioned mass that has a hemorrhagic necrotic red-tan softened cut surface with bright focal areas of fat necrosis. A central yellow-gray scar is. identified. The tumor is 2.2 cm away from the margin of resection. It extends to the capsule and appears to press into the attached liver parenchyma. No. other lesions are identified. Photographs have been taken. 1A. Tumor to margin of resection. 18. Tumor to liver and capsule.. 1c. Tumor to necrotic area.. 1D. Possible viable tunor to liver. 1e. Tumor to capsule. 1F. Normal liver.
+
+--- Page 2 ---
+PREVIOUS DIAGNOSIS INQUIRY REPORT DATE: PAGE #: NAME: SEX: F BIRTHDATE: ADM DATE: OPER DATE: PROCEDURE: SPMI LIVER: HEPATOCELLULAR CARCINOMA WAS THE TUMOR PREVICUSLY TREATED?: NoE TUMOR TYPE: Ordinary SINGLE OR MULTIPLE MASSES: Single MAXIMUM DIAMETER OF LARGEST MASS: 14 cmE ARE THE MARGINS OF RESECTION FREE OF TUMOR?: Yes VASCULAR INVASION?: Yes INVASION THROUGH THE CAPSULE TO THE SEROSAL SURFACE?: No LYMPH NODE METASTASES?: UnknOwn DISTANT METASTASES?: Unknown IS THE LIVER CIRRHOTIC?: Yes pT2 NX PROCEDURE: SPDX VERIFIED BY: 1. Left lateral segment of liver, excision: Hepatocellular carcinoma (14cm), With vascular invasion. Margins free. Please see template for full details. Background liver with cirrhosis and steatohepatitis. I, the signing staff pathologist, have personally. examined and interpreted the slides from this case. Code: fw 8pa|l3 A
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diff --git a/output/text/d3224304-ffb4-4a50-8bd3-113678425d4e.txt b/output/text/d3224304-ffb4-4a50-8bd3-113678425d4e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5a63813c781cc664e4995bf5bc965f2cb79ae0f1
--- /dev/null
+++ b/output/text/d3224304-ffb4-4a50-8bd3-113678425d4e.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+IcD0-3 Careenoms,wrstkelaI NsS 8/2013 UUID: 528501A3-F7C9-4D93-AC98-7CFFF0C11D0A TCGA-4Z-AA84-01A-PR Site Hcedder NsS Redacted C 67.9 LJ 3|18/4 Collect date (mm/DD/YYyY) PATHOLOGY REPORT: PRIMARY SITE: Bladder Product partial cystectomy: - Urothelial high grade carcinoma, extensively necrotic, infiltrating into the perivesical adipose tissue. - Surgical margins uninvolved, but close at top left portion (1.9 mm). - Angiolymphatic infiltration: present. - Perineural infiltration: not detected. - Absence of neoplastic infiltration of the right and left ureter and on the rectal wall fragment. - Presence of metastases in two lymph nodes dissected (2/2). Pathological staging: pT3b, pN2, pMX. J 13/20/13
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diff --git a/output/text/d3258e6b-1bc3-4723-b41d-1426de465ebe.txt b/output/text/d3258e6b-1bc3-4723-b41d-1426de465ebe.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0f2cb835eea7742ca38e7ebbd238b8726b875292
--- /dev/null
+++ b/output/text/d3258e6b-1bc3-4723-b41d-1426de465ebe.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:D677E858-2615-413D-859E-588928684398 TCGA-C5-A7CO-01A-PR Redacted SURGICAL PATHOLOGY REPORT - CONSULT Patient Name: Address: Service: Accessian # Location: Received, Gender. MRN: Reported: DOB: (Age  Hospital #. zcD-O-3 Patient Type: 8d 7o/3 Physician(s): m.D. 053.0 Cy f/a9/13 DIAGNOSIS 1 Uterus, enDocervIx Curettage ( - INVASiVE, MODERATELy DIFFEReNTIATED SQUAMOUS CELL CARCINOMA UteRUS, "eNoOmetrIUm," CURettagE :  - INVASIVE, MODERATELY DIFFERENTIATED SQUAMOUS CELL. CARCINOMA  - NO ENDOMETRIAL TISSUE IDENTIFIED By this signsture. I atest thad the above dagnosis is bxsed upon my persona! txaminstion of t sides(and/as other mnsterialindicated in the dingnosis). 1 M.D. ***Repon Electronically Reviewed and Slgned Out By.. M.D..* Microscopic Description and Comment Microscopic examination substantiates the above cited diagnosis. .. .. History M.D The patient is a Material(s) Received Received are four slides labeled..  accompanied by a corresponding pathology report date The material originates from Page 1011 END OF REPORT lw 8/19/!
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diff --git a/output/text/d3761bde-81c4-4215-aae4-2c2de4b6bc48.txt b/output/text/d3761bde-81c4-4215-aae4-2c2de4b6bc48.txt
new file mode 100644
index 0000000000000000000000000000000000000000..878dbcd7dbeefe6a4e0135b1ddba2490d2db0628
--- /dev/null
+++ b/output/text/d3761bde-81c4-4215-aae4-2c2de4b6bc48.txt
@@ -0,0 +1,21 @@
+
+--- Page 1 ---
+UUID:D01E9054-D909-4290-AA19-9847714DF09B TCGA-CN-A63W-01A-PR Redacted CORRECTED tcD-o-3 aeerones, keeuensexo) Report Type Patholoav Report 0807d/3 CeQQ NOS Date of Event Sex .. F Silc:sLaryy NSS C3Q.9 Authored by .. Hosp/Group WJ S/o/13 Record Status .. CORRECTED COMPREHENSIVE THERANOSTIC SUMMARY IMMUNOHISTOCHEMISTRY : p16: RESULTS NEGATIVE IN SITU HYBRIDIZATION / FISH: RESULTS HPV: NEGATIVE **See Special Procedure reports below for additional details and background on. In situ/Fish and/or Molecular Anatomic Pathology testing as pertinent** Pathologist: ** Report Electronically Siqned Out ** By Patholoaist: My signature is attestation that I have personally reviewed the submitted material(s) and the above diagnosis reflects that evaluation. FINAL DIAGNOSIS: PART 1: LYMPH NODES, LEFT NECK LEVELS 2 THROUGH 4, SELECTIVE DISSECTION A. METASTATIC SQUAMOUS CELL CARCINOMA IN FOUR OF THIRTY-TWO LYMPH NODES (4/32). B. EXTRANODAL EXTENSION PRESENT. C. POSITIVE LYMPH NODES IN LEVEL 3 (LARGEST: 1.5 CM). PART 2: LYMPH NODES, RIGHT NECK LEVELS 2 THROUGH 5, SELECTIVE DISSECTION A. METASTATIC SQUAMOUS CELL CARCINOMA IN SOFT TISSUE (6.O CM) EXTENDING FROM LEVEL 2 THROUGH LEVEL 4 INVOLVING ADVENTITIA OF LARGE VEIN AS WELL AS INVOLVING SKELETAL MUSCLE (CONSIDERED ONE POSITIVE LYMPH NODE WITH EXTRANODAL EXTENSION FOR STAGING PURPOSES). 3. THIRTY-TWO ADDITIONAL LYMPH NODES, NO TUMOR PRESENT (TOTAL: 1/33). C. MARGINS OF NECK DISSECTION FREE OF TUMOR.
+
+--- Page 2 ---
+PART 3: THYROID, RIGHT, EXCISION (695 MG) CHRONIC LYMPHOCYTIC THYROIDITIS. PART 4: TONGUE, LEFT BASE DEEP MARGIN NO TUMOR PRESENT. PART 5: TONGUE, RIGHT BASE DEEP MARGIN NO TUMOR PRESENT. PART 6: LARYNX, TONGUE, AND RIGHT THYROID (6 GRAMS), LARYNGECTOMY, PARTIAL GLOSSECTOMY, THYROID LOBECTOMY A. INVASIVE SQUAMOUS CELL CARCINOMA, MODERATELY DIFFERENTIATEDS (6.5 CM), MIDLINE SUPRAGLOTTIC WITH BASE OF TONGUE AND HYPOPHARYNGEAL ExTeNSIOn. B. PERINEURAL INVASION PRESENT, ANGIOLYMPHATIC INVASION PRESENT. C. TUMOR EXTENDS INTO SOFT TISSUE INCLUDING BASE OF TONGUE MUSCULATURE. D. MARGINS FREE, SEE ALSO OTHER PARTS (CLOSEST MARGIN: O.5 CM, RIGHT ARYEPIGLOTTIC FOLD/PYRIFORM SINUS). E. ONE CENTRAL COMPARTMENT (LEVEL 6) LYMPH NODE, NO TUMOR PRESENT) (0/1). F. PATHOLOGIC STAGE pT4a N2c. G. THYROID WITH CHRONIC LYMPHOCYTIC THYROIDITIS.S PART 7: BASE OF TONGUE, MARGIN, EXCISION NO TUMOR PRESENT. Pathologist: ** Report Electronically Signed Out ** By Pathologist: My signature is attestation that I have personally reviewed the. submitted material(s) and the final diagnosis reflects that evaluation. GROSS DESCRIPTION: The specimen is received unfixed in seven parts. Part 1 is labeled with the patient's name, initials xxx and "left neck level 2-4". The specimen consists of a 9.0 x 4.0 x 2.2 cm selective neck dissection. The specimen is arbitrarily divided into 3 equal levels and potential lymph nodes are dissected out.. Level 2: 16 lymph nodes are dissected are ranging in size from 0.3 x 0.3 x 0.2 cm to 1.0 x 0.8 x 0.4 cm. Level 3: 7 lymph nodes are dissected out ranging in size from 0.4 x 0.5 x 0.3 cm to 1.5 x 1.5 to 1.0 cm. Level 4: 8 lymph nodes are dissected are ranging in size from 0.3 x 0.2 x 0.2 cm to 0.8 x 0.4 x 0.3 cm. Remainder of the tissue consists of tan-yellow, lobular adipose tissue intermixed with muscle and vessels. Section code:
+
+--- Page 3 ---
+1A-1D - level 2 lymph nodes 1E, 1F - trisected largest lymph node from level 3. 1G - remaining level 3 lymph nodes 1H, 1I - level 4 lymph nodes Formalin exposure time: 28 hours Part 2 is labeled with the patient's name, initials xxx and "right neck stitch at top of skull base". The specimen consists of a 11.5 x 10.0 x 4.5 cm selective neck dissection. There is a suture present designating the top of skull base. The specimen is are truly divided into 4 equal levels and potential lymph nodes are dissected out: Level 2: Nine lymph nodes are dissected out ranging in size from 0.3 x 0.2 x 0.2 cm to 1.2 x 1.0 x 0.4 cm. Level 3: Nine lymph nodes are dissected are ranging in size from 0.5 x 0.3 x 0.3 cm to 1.2 x 1.0 x 0.4 cm. Level 4: Seven lymph nodes are dissected out ranging in size from 0.2 x 0.2 x 0.2 cm to 0.6 x 0.5 x 0.3 cm. Level 5: Five lymph nodes are dissected out ranging in size from 0.2 x 0.2 x 0.1 cm to 0.4 x 0.3 x 0.2 cm. There is a 6.0 x 2.5 x 2.5 cm tan-gray, firm thinly encapsulated. slightly cystic lesion present which extends from level 2 through level 4. The lesion extends to within less than O.1-cm of the wall of an adjacent vessel. The remainder of the tissue consists of tan-brown, soft to firm muscle with adherent vessel and adipose tissue. Digital images are taken.. Section code: 2A-2C - lesion with vessel. 2D-2F - lymph nodes from level 2 2G, 2H - lymph nodes from level 3 2I - lymph nodes from level 4 2J - lymph nodes from level 5 Formalin exposure time: 28 hours Part 3 is labeled with the patient's name, initials xxx and "right thyroid". measuring 1.5 x 1.0 x 0.6 cm and weighing 695 mg. The specimen is bisected and entirely submitted on cut surface following frozen section consult in cassette labeled 3Afs. Formalin exposure time: 28 hours Part 4 is labeled with the patient's name, initials xxx and "left tongue base deep margin".  The specimen consists of a tan-pink, soft to firm. fragment of tissue measuring 1.0 x 0.9 x 0.4 cm. Following frozen section consult the specimen is entirely submitted in cassette labeled 4AFs.. Formalin exposure time: 28 hours.
+
+--- Page 4 ---
+Part 5 is labeled with the patient's name, initials xxx and "right tongue base deep margin". The specimen consists of a 1.0 x 0.5 x 0.4-cm tan-gray, soft to firm portion of tissue. Following frozen section consult the specimen is entirely submitted in cassette labeled 5AFs.. Formalin exposure time: 28 hours Part 6 is labeled with the patient's name, initials xxx and "larynx and tongue". The specimen consists of a total thyroidectomy specimen measuring 11.0 x 7.5 x 2.8 cm overall with a 4.0 x 3.5 x 2.0 cm portion of base of There is a 4.0 x 1.0 x 0.6 cm portion of hyoid bone present. tongue. There is a 3.5 x 1.5 x 1.0 cm right thyroid lobectomy present weighing 6 g. There is a supraglottic 6.5 x 5.0 x 2.0 cm tan-gray, firm, fungating ulcerated lesion present at the base of tongue. The lesion extends to within 0.3 cm of the left base of tongue edge, 0.4 cm of the medial base of tongue edge, 0.3 cm of the right base of tongue edge. The lesion extends into the right pyriform sinus and comes to within 0.5 cm of the margin. The lesion also at the left pyriform sinus and comes to within 1 cm of the sinus margin. The lesion extends to within 0.5 cm of the right false cord and 1.0 cm of the left false The cord. The lesion comes within 5 cm of the distal tracheal margin.. lesion grossly extends through the muscle and comes to within 0.4 cm of the inked anterior soft tissue margin. The lesion comes to within 0.l-cm the. entire bone bed. The epiglottis is almost entirely obliterated by the lesion. The lesion grossly does not extend to either the right or left false cords and the cartilage is grossly uninvolved. The right false cord mucosa is. slightly granular with no lesion is grossly identified.. The vocal cords and remaining laryngeal mucosa is tan-gray, soft and grossly The right thyroid cut surface is tan-brown, soft and. unremarkable. firm and diffusely nodular with a tan-yellow, firm circumscribed nodule present.. Six potential lymph nodes are dissected out ranging in size from 0.3 x 0.2 x 0.1 cm to 0.7 x 0.3 x 0.3 cm.  Digital images are taken and Tissue is procured for the head and neck spore tissue bank Ink code: Blue- right pyriform sinus margins Green- left pyriform sinus margin
+
+--- Page 5 ---
+Black- anterior soft tissue margin Red- area banked. orange-hyoid bone bed. Section code: 6A - distal tracheal ring 6B - right pyriform sinus margin 6C - left pyriform sinus margin 6D - right false and true cords with lesion 6E - left true and false cords with lesion 6E - anterior commissure with lesion 6G - lesion and anterior soft tissue with hyoid bone bed 6H - lesion and anterior soft tissue 6I - and representative cross sections of right thyroid lobe 6J - potential lymph nodes Formalin exposure time: 28 hours Part 7 is labeled with the patient's name, initials xxx and "tongue. base margin". The specimen consists of a 2.0 x 0.5 x 0.3 cm tan-gray, soft to firm portion of tissue. Following frozen section consult the specimen is entirely submitted in cassette labeled 7AFs. Formalin exposure time: 28 hours GROSSED BY: INTRAOPERATIVE CONSULTATION: 3 AFS: THYROID, RIgHT, BIoPSy (frozen section)-- A. SUFFICIENT FOR ANCILLARY STUDIES. B. DEFER. C. FAVOR CHRONIC LYMPHOCYTIC THYROIDITIS 4 AFS: TONGUE, LEFT BASE, DEEP MARGIN, EXCISION (frozen section)- A. SUFFICIENT FOR ANCILLARY STUDIES. B. BENIGN. C. NO TUMOR SEEN 5 AFS: TONGUE, RIGHT BASE, DEEP MARGIN, EXCISION (frozen seCtion)- A. SUFFICIENT FOR ANCILLARY STUDIES. B. Benign. C. NO TUMOR SEEN 7 AFS: ). TONGUE, BASE, MARGIN, EXCISION (frozen section)- A. SUFFICIENT FOR ANCILLARY STUDIES. B. Benign. C. NO TUMOR SEEN MICROSCOPIC: Microscopic examination substantiates the above diagnosis. The following statement applies to all immunohistochemistry, Insitu Hybridization Assays (Ish & FIsh), Molecular Anatomic Pathology, and Immunofluorescent Testing: The testing was developed and its performance characteristics determined bv the Department of Pathology, as required by the CLIA '88 regulations.  The testing has not been cleared or approved for the specific use by the U.S. Food and Drug Administration, but the FDA has determined such approval is not necessary for clinical use. Tissue fixation
+
+--- Page 6 ---
+ranges from a minimum of 2 to a maximum of 84 hours.. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 ("cLiA") as qualified to perform high-complexity clinical testing. Pursuant to the requirements of cLiA, AsR's used in this laboratory have been established and verified for accuracy and precision. Additional information about this type of test is available upon request. CASE SYNOPSIS: SYNOPTIC DATA - LARYNX RESECTIONS TYPE OF LARYNGECTOMY: Extended TUMOR LATERALITY: Midline ATTACHED STRUCTURES: Base of tongue, Thyroid TUMOR LOCATION/SEGMENT: Supraglottic TUMOR SIZE: Maximum dimension: 6.5 cm HISTOLOGIC TYPE OF TUMOR: Squamous cell carcinoma HISTOLOGIC GRADE: Moderately differentiated STRUCTURES INVOLVED BY TUMOR: False cord, Epiglottis, A-E Fold - Both surfaces, Vallecula-base of tongue, Pre-epiglottic space, Extralaryngeal soft tissue LYMPH NODES:  Lymph nodes positive, Right: 1 Total number of right sided lymph nodes examined: 33. Lymph nodes positive, Left: 4 Total number of left sided lymph nodes examined: 32. Site of 'other' lymph nodes: level vI Lymph nodes positive, 'other': 0 Total number of 'other' lymph nodes examined: 1 EXTRACAPSULAR SPREAD OF LYMPH NODE METASTASES Yes INTRA-PERINEURAL INVASION: Present VASCULAR INVASION: Yes SURGICAL MARGIN INVOLVEMENT: Free (2 mm or more). T STAGE, PATHOLOGIC: Supraglottis, pT4a N STAGE, PATHOLOGIC: pN2c M STAGE, PATHOLOGIC: pMX PATIENT HISTORY: CHIEF COMPLAINT/PRE-OP/POST-OP DIAGNOSIS: LarynX cancer PRoceDurE: Bilateral neck dissection, laryngectomy. SPECIFIC CLINICAL QUESTION: Not answered OUTsiDE TIssUE DIagnosIS: Not answered PRIOR MALIGNANCY: Not anSwered CHEMOTHERAPY: Not answered ORGAN TRANSPLANT:  Not answered IMMUNOSUPPRESSION: Not answered OTHER DIsEASES: Not answered HISTO TISSUE SUMMARY/SLIDES REVIEWED: Part 1: Neck Dissection, Levels 2-4 Stain/ Block H&E x 1 A H&E x 1 B H&E x 1 c
+
+--- Page 7 ---
+H&E x 1 D H&E x 1 E H&E x 1 E H&E x 1 G H&E x 1 H H&E x 1 I Part 2: Right Neck Dissection Stain, Block H&E x 1 A H&E x 1 B H&E c H&E x D H&E x E H&E x 1 F H&E x G H&E x 1 H H&E x 1 1 H&E x 1 J Part 3: Thyroid, Right Stain/ Block H&E x 1 AFS Part 4: Tongue, Left Base Deep Margin Stain/ Block H&E x 1 AFS Part 5: Tongue, Right Base Deep Margin Stain/ Block H&E x 1 AFs Part 6: Larynx and Tongue Stain/ Block H&E x 1 A H&E x B H&E x 1 c H&E x 1 D H&E x 1 E H&E x 1 F ANEg Mouse x 1 G HCOM x 1 G ISHBNK x ISHBNK x G G H&E x 1 G HPV x 1 G IISH x 1 G 216 x 1 G H&E x 1 H H&E x 1 I H&E x 1 J Part 7: Tongue,.  Base Marqin. Stain Block H&E x 1 AFS TC1 4//13
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diff --git a/output/text/d3b5666c-1b0a-4aef-a5ff-62b1436dbc7f.txt b/output/text/d3b5666c-1b0a-4aef-a5ff-62b1436dbc7f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3325a27a6cbaa3b3dc02935deef507d5bcf1e14b
--- /dev/null
+++ b/output/text/d3b5666c-1b0a-4aef-a5ff-62b1436dbc7f.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+tcD-6- Chsomophobe. tyyee SURGICAL PATHOLOGY 0831z/3 Case Number : C6t9 Diagnosis: J 8J9l13 Kidney, left, nephrectomy Histologic tumor type/subtype: Renal cell carcinoma, chromophobe subtype Sarcomatoid features: None identified Histologic grade (if applicable): 3 (of 4) Tumor size (greatest dimension): 5.0 cm Tumor focality: Unifocal Extent of tumor invasion (if present specify if macroscopic or microscopic) : Capsular invasion/perirenal adipose tissue: Not identified Gerota' s fascia: Not identified Renal sinus: Not identified Major veins (renal vein or segmental branches, Ivc): Not identified Ureter: Not identified Venous (large vessel): Not identified Lymphatic (small vessel): Not identified Histologic assessment of surgical margins: Gerota' s fascia (nephrectomy): Not identified Renal vein (nephrectomy): Not identified. Ureter (nephrectomy): Not identified Adrenal gland: Not present in specimen Lymph nodes: Not identified in specimen. Other significant findings: None Redacted AJCc Staging: pT1b pNx This staging information is based on information available at the time of this report, and is subject to change pending
+
+--- Page 2 ---
+clinical review and additional information. clinical History: -year-old female with a left renal mass. Gross Description: Specimen fixation: formalin. Type of specimen: radical nephrectomy, left. Side of specimen: left Size and weight of specimen: 450 grams, 20.0 cm x 11.0 x 5.0 cm Orientation: The external surface is inked blue. Presence/absence of adrenal gland: absent Tumor site: Superior pole involving the cortex grossly Tumor description: yellow, spongy, well circumscribed Tumor size: 5.0 x 4.0 x 3.0 cm Presence/absence of multicentricity: absent Confinement/non-confinement to the kidney: confined to, but expands but does not break through capsule. Extent of invasion: Perirenal adipose tissue: does not involve Gerota' s fascia: does not involve. Renal vein: does not involve. Ureter: does not involve Renal Sinus: does not involve Pelvicaliceal: does not involve Adrenal: not applicable
+
+--- Page 3 ---
+Other organs: not applicable Surgical margins: Perirenal adipose tissue: negative Renal vein: negative Renal artery: negative Ureter: negative Description of kidney away from tumor: tan/pink, homogeneous Hilar lymph nodes: none identified Other significant findings: The remainder of the kidney is tan,. homogeneous without cysts or other lesions. On the upper pole of. the kidney directly over the tumor, the capsule is not entirely. covered by perirenal 'fat. This portion of the capsule has been. inked blue.. Tissue submitted for normal and tumor Digital picture: not taken Block summary: Al - ureter, renal vein and renal artery margins A2 - tumor and adjacent parenchyma A3 - tumor and adjacent calyces A4 - tumor and adjacent blue inked capsule A5 - additional representative of tumor and normal parenchyma. A6 - normal kidney Jw 7|30|13
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diff --git a/output/text/d3cead95-5c9f-4fea-ad3c-fc2eb031f2eb.txt b/output/text/d3cead95-5c9f-4fea-ad3c-fc2eb031f2eb.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9ec4b413f6522dae88d6318784ddd46e53665eb6
--- /dev/null
+++ b/output/text/d3cead95-5c9f-4fea-ad3c-fc2eb031f2eb.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+TCGA-CM-4752 Clinical Diagnosis & History: Right-sided colon cancer. Specimens Submitted: 1SP: Right colon DIAGNOSIS: COLON RIGHT HEMICOLECTOMY: 1. TUMOR TYPE:ADENOCARCINOMA. HISTOLOGIC GRADE: MODERATELY DIFFERENTIATED. TUMOR LOCATION:ASCENDING COLON. TUMOR SIZELENGTH IS 4.0 CM WIDTH IS 5.4 CM GROSS CONFIGURATION: ULCERATING INFILTRATIVE. TUMOR INVASION: INVASION INTO SUBSEROSA. GROSS TUMOR PERFORATION: NOT IDENTIFIED. -SEROSAL INVOLVEMENT:NOT IDENTIFIED. VASCULAR INVASION NOT IDENTIPIED -PERINEURAL INVASION: IDENTIFIED. SURGICAL MARGINS FOR COLONIC TOMORS:FREE OF TUMOR. -NON-NEOPLASTIC BOWEL UNREMARKABLE pT3 THE PATHOLOGIC STAGE IS OMBER EXAMINED:23. -LYMPH NODES: NUMBER WITH METASTASES pNO THE PATHOLOGIC STAGE IS SIGNEPICANT PATHOLOGIC CHANGE. -APFENDIX AND OMENTUM WITH NO S I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED URON MY PERSONAL EXAMINATION OF THE SLIDES AND/OR OTHER MATERIAL)AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. 1 The specimen is received fresh, labeled Right colon" and con Continued on next page **
+
+--- Page 2 ---
+aegment of terminal ileum, cecum with attached appendix and ascending colon. The terminal ilaum measures 8 cm in length and 3.4 cm in circumference at the proximal resected margin. The remaining colon measures 34 cm in length with a circumference of 8 cm at the distal resected margin. The attached appendix measurea 7.2 cm in length and averagea 0.6 cm in diameter. The appendiceal and intestinal serosa is pink tan and smooth. Focally hemorrhagic lobulated yellow tan adipose tissue apans the length of the specimen measuring up to S cm in thicknesa. The specimen is opened to reveal a mass lesion measuring 4 cm in length and 5.4 cm in width Sectioning shows tbat the tumor invades into the paricolic fat. The depth of nvasion is 0.5 cm grossly. The lesion is 5 cm from the distal margin. There ia attached omental fat measuring 25 x 12 x 1.5 cm. It ia grossly unremarkable. The remaining mucosa is unremarkable.Multiple lymph nodes are identified in the attached adipoae tissue and are submitted. Representative sections of the specimen are gubmitted for permanent sections and for TPS. Summary of sactions: PM--proximal margin shave DM-distal margin shave M--mass A-- appendix representative sections RS--reprosentative sections O-omentun representative sections LN--lymph nodes Summary of Sections: Part 1: SPRight colon Block Sect.site PCs A 1 4 BLN 8 1642 DM 18 LN M PM H RS End of Raport
\ No newline at end of file
diff --git a/output/text/d3e375b2-d98a-42bd-9643-4f4d66b95975.txt b/output/text/d3e375b2-d98a-42bd-9643-4f4d66b95975.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4869ba3b5769c1c8eb35b5e358b9bd7a27304fe5
--- /dev/null
+++ b/output/text/d3e375b2-d98a-42bd-9643-4f4d66b95975.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+FINAL DIAGNOSIS: . PArt 1: Left AxIlLA, SenTinel Lymph nOde #1, BiOpSy  One Left axillary sentinel Lymph node #1 with metastatic breast Carcinoma (1/1). Part 2: BrEAst, LEet, moDified rAdical mastectomy - A. MULT!FOCAL INFILTRATInG MIXED DUCTAL AND LOBULAR CARCINOMA (see comment). B. TumOR mEASUreS 6.0 X 5.5 X 2.5 CM. C. The tumOr is LOcaTed in The UppEr Outer, LOWer Outer, upper Inner AnD LOWer inNer QUADRANTS AND IN THE CENTRAL AREA ( MULTICENTRIC TUMOR ). D. ANGIOLYMPHATIC INVASION IDENTIFIED. E.  LOBULAR CARCINOMA iN SITU ACCOUNTING FOR 10% OF THE TUMOR, ADMiXED WITH THE TUMOR. F. ALL MARGINS ARE NEGATIVE FOR INVASIVE MIXED DUCTAL - LOBULAR CARCINOMA AND LOBULAR CArcinoma in situ. G. NIPPLE WITH FOCAL INVASIVE CARCINOMA IN THE DEEP STROMAL TISSUE. H. NIPPLE AND SKIN OF THE BREASt WITH DUCt ECTASIA AND ChRONiC INFLAmmATION. 1. ESTROGeN RECEPTOR POSITIVE, pROGESTERONE RECEpTOR POSITIVE, hER-2/NeU nEGATIVE FOR (SCORE +1) AS PER CORE BiOPSY ' J. BIOPSY SITE CHANGES. K. FIBROCySTIC CHAnGES WiTH DUCTal EPITHeLIAl HYPERPLASIA. COLUMNAR CELL CHANGES. L. M. MICROSCOPIC PERIPHERAL DUCTAL PAPILLOMA. N. AXILLARy TaIl WIth TWenty Out Of TWenTy Lymph nODES With meTASTatiC CARcinOmA (0.5 TO 2.2 CM IN MAXIMUM DIAMETER) (20/20) TOW HAVE EXTRA CAPSULAR SPREAD Part 3: Left pectoraLis minor muscle, excision - STRIATeD SKELETAL MUSCLE FREE OF TUMOR CONFIRM BY iMMUnOSTAIN fOR Part 4: Left axillA, Level 3, Lymph node, excision - SIX Lymph NODeS LEVEL 3 ALL pOsiTivE FOR mEtASTaTiC CARcInOmA (6/6) (see comment). CASE SYNOPSIS: SyNOPTIC - PRImARy iNVASIVE CARCiNOMA OF BREAST 1cs-0-3 LATERALITY: Left Cuscinona, nifthshng dwt ard 1ohale 857|: PROCEDURE:  Modified radical mastectomy Sit:brust No3 C50r9 : 3/3/n L LOCATION: Central subareolar Upper outer quadrant Upper inner quadrant Lower outer quadrant Lower inner quadrant Not specified SiZE OF TUMOR:  Maximum dimension invasive component: 6.0 cm MULTICENTRICITY/MULTIFOCALiTY OF INVASIVE FOCI: Yes TUMOR AGGREGATE SIZE:  Sum of the sizes of multiple invasive tumors: 6.3 cm TUmOR TYPE (invasive component): Other Type(s): MIXED D &L HIStOLOgIC Type: Classical, Pleomorphic NOTTINGHAM SCORE: Nuclear grade: 2 UUID:142F03FE-5860-416D-80CD-EC34D85495DB Tubuie formation: 3 TCGA-BH-A0BA-01A-PR Redacted Mitotic activity score: 1 Total Nottingham score: 6 Nottingham grade (1, 2, 3): 2 ANGIOLYMPHATIC INVASION: Yes DERMAL LYMPHAT!C INVASION: No CALCIFICATION: Yes, benign zones Tumor type, in situ: LCIS, Percent of tumor occupied by in situ component: 10 % SURGICAL MARGINS INVOLVED BY iNVASIVE COMPONENT: SURG MARGINS INVOLVED BY IN SITU COMPONENT: No No Paget's DiseaSe Of nipple: No LYMPH NODES POSITIVE: 27 LyMPh nODeS EXAMINED: 27 METHOD(S) OF LYMPH NODE EXAMINATiON: H/E stain, Keratin stain SENTINEL NODE METASTASIS: Yes ONLY KERATIN POSITIVE CELLS ARE PRESENT: (13/# No SIZE OF NODAL METASTASES: Diameter of largest lymph node metastasis: 20 mm LYMPH NODE METASTASIS(-ES) WITH EXTRACAPSULAR EXTENSION: METASTASES TO IPSILATERAL iNTERNAL MAMMARY LYMPH NODE (iF APPLICABLE): No No SKIN INVOLVED (ULCERATION): No NON-NEOPLASTIC BREAST TISSUE: ALH, Papilloma, FCD t Stage, PathoLOgIC: pT3 N Stage. PathologIC:
\ No newline at end of file
diff --git a/output/text/d3f4dd54-028f-4b85-9cb0-a53eba6d1d3a.txt b/output/text/d3f4dd54-028f-4b85-9cb0-a53eba6d1d3a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6df337258e11f400740d25e63b64fabcc703a213
--- /dev/null
+++ b/output/text/d3f4dd54-028f-4b85-9cb0-a53eba6d1d3a.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+CGA-A6-2682 SPECIMEN A. Right colon B. Apical lymph node CLINICAL NOTES PRE-OP DIAgnosIs: Ascending colon cancer. GROSS DESCRIPTION A. Received fresh for tissue procurement labeled "right colon" is a 35 cm. segment of proximal right colon with attached 48 cm. of distal ileum surfaced by smooth to scabrous tan-pink serosa with a copious amount of attached mesocolon, mesentery, and unremarkable omentum. An appendix is not identified grossly. The proximal and distal margins measure 3.8 and 6.2 cm. in circumference respectively. The proximal 10 cm. of ileum is adhesed to the cecal pouch, which on opening, contains a circumferential 9 x 5.5 cm. rubbery tan-white tumor mass. On sectioning, the tumor has a maximal thickness of 3.5 cm., grossly extending through the muscularis to within 0.2 cm. of the inked free radial serosal surface. The mucosa throughout the remainder of the ileum and colonic segment is unremarkable glistening tan-pink with regular folds and the walls average 0.5 cm. in thickness. No additional abnormalities are noted. A portion is taken for tissue procurement as requested. Several soft tan-pink to rubbery tan-white tissues in keeping with lymph nodes measuring up to 2 cm. in greatest dimension are recovered from the attached mesentery and mesocolon. Representative sections are submitted in 16 blocks as labeled. RS- 16 BLOCk suMMARy: 1 - proximal and distal margins; 2 - tumor with. adhesed portion of ileum; 3 and 4, 5 and 6 - tumor full thickness to inked free radial serosal surface (black) - points of continuity inked orange and green respectively; 7 - tumor to proximal mucosa; 8 - tumor to distal mucosa; 9 - random ileum; 10 - random colon; 11 -
+
+--- Page 2 ---
+GROSS DESCRIPTION 2 whole lymph nodes; 12 - 6 whole lymph nodes; 13-15 - 1 bisected lymph node per cassette; 16 - 1 representative section from each of 2 grossly positive lymph nodes. B. Received fresh labeled "apical lymph node" is a 0.6 x 0.35 x 0.2 cm. fragment of soft to slightly rubbery glistening to chalky golden yellow adipose tissue. A definitive lymphoid tissue is not. recovered. The specimen is submitted in toto. in one block. As-1. MICROSCOPIC DESCRIPTION Histologic type: Adenocarcinoma, not otherwise specified.. Primary tumor (pT): Tumor invades through the entire colonic wall into the adhesed section of ileum into the muscularis propria of the ileum, through the muscularis propria and into the submucosa of the ileum. This is shown in slide A2 (pT4b).. Proximal margin: Negative for tumor.. Distal margin: Negative for tumor.. Circumferential (radial) margin: Not applicable. Distance of tumor from closest margin: 10 cm from the ileal margin. Vascular invasion: Prominent lymphatic and venous space invasion is identified. Regional lymph nodes (pN): 2 of 13 lymph nodes are positive for metastatic carcinoma (pN1). Non-lymph node pericolonic tumor: Focally present in the mesenteric fat between the ileum and colon. Distant metastasis (pM): Cannot evaluate (pMx). Other findings: None. MICROSCOPIC DESCRIPTION 5x1, 3260F DIAGNOSIS Colon, right, ileocolectomy:. Invasive, moderately differentiated adenocarcinoma, invasive through the entire right colonic wall and through the visceral peritoneum into the wall of the adhesed ileum (pT4b). Metastatic adenocarcinoma present in 2 of 13 lymph nodes (pNl). The resection margins are negative for carcinoma. Prominent lymphatic and venous space invasion is identified
\ No newline at end of file
diff --git a/output/text/d3f7ef8c-3684-487b-850a-b1afdd1e2b3e.txt b/output/text/d3f7ef8c-3684-487b-850a-b1afdd1e2b3e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f00d151d3b4fea79d54bdacba6adb863979e697a
--- /dev/null
+++ b/output/text/d3f7ef8c-3684-487b-850a-b1afdd1e2b3e.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+7nd f+wo Phmario UUID:BAE8C63F-81B6-431A-9431-23ACAC11BAD0 (Stnt nt santme) TCGA-UZ-A9PS-05A-PR Redacted SURGICAL PATHOLOGY REPORT Patient Name! Accession #:1 Med. Rec.#: Visit #: Service Date: 1 DOB: Sex: Female Received: Location: Client: Soc. Sec. #: Physician(s): FInal Pathologic Diagnosis Right kidney, partial nephrectomy: 1. Renal cell carcinoma, papillary (chomophil) type, Fuhrman nuclear grade 3, 3.6. cm in greatest dimension.n. 2. Tumor extends into but not through the overlying renal capsule. 3. Tumor approaches focally to within 0.1 cm of parenchymal resection margin, but is not seen at the margin itself. 4. Incidental benign simple renal cyst, 0.6 cm. ICD 63 'Wryngnb, yeaeeIlsey renx Comment: ceIC CdrersphiD) 8Qo0l3 Kidney Tumor Synoptic Comment: -Histologic type: Papillary (chromophil) type. -Grade: Fuhrman nuclear grade 3 (of 4) -Maxlmum tumor diameter: 3.6 cm. YI b|3o|/y -Renal pelvis: Not present.. -Ureter: Not present. -Renal sinus: Not present.. -Hilar renal velns: Not present. -Intrarenal veins and lymphatics: Normal. -Adrenal gland: Not identified. -Capsule/perirenal fat: Tumor invades but does not extend through capsule. -Hilar lymph nodes (number positive/number of nodes): Not applicable.. -Resection margins: Negative. -Proxlmity to nearest margin: 0.1 from parenchymal resection margin.. -Stage:  pT1aNXMX. -Additiona! Comments: Select slides (slides A1 and A4) were shown at the departmental , and the faculty in attendance concurred with the above diagnoses on. Specimen(s) Received Page 1 of 2
+
+--- Page 2 ---
+A:Right Partial Nephrectomy Clinical History The patient is a year-old woman with history of papillary renal cell carcinoma in the left kidney. She. now has a mass in the right kidney and undergoes partial nephrectomy.. Gross Description The specimen is received fresh in one part, labeled with the patient's name and medical record number. and "Right kidney mass." It consists of a red-brown, firm partial nephrectomy specimen, measuring 21. x 5 x 4 cm and weighing 28.3 gm. There is a white-yellow, solid, firm, spheroid, Iobulated, and. encapsulated mass, measuring 3.6 cm in diameter, replacing >95% of the kidney parenchyma. This mass abuts the parenchymal resection margin in multiple areas. In addition, there is a white-yellow, uninoculated cyst, measuring 0.6 cm in diameter, located on the kidney surface. This cyst is 3.2 cm from the resection margin. The resection margin is inked black for microscopic evaluation. The specirnen was opened to show the surgeon the tumor in relation to the resection margin.. Representative sections are submitted as follows: Cassette A1: Tumor in closest approach to resection margin. Cassette A2: Representative section of tumor and cyst. Cassette A3: Representative section of tumor and renal parenchyma.. Cassettes A4-A5: Representative sections of tumor. Diagnosis based on gross and microscopic examinations. Fina! diagnosis made by attending pathologist. following review of all pathology slides. Pathology Resident Pathologist Electronically signed out on  ^g f 2 primuriis-Sint at Som time d 1k/!y 1g40013 Page 2 of 2
\ No newline at end of file
diff --git a/output/text/d3fb9fd0-8c83-4670-aefc-d5d9b5b7ec9f.txt b/output/text/d3fb9fd0-8c83-4670-aefc-d5d9b5b7ec9f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ffe446547df8af33c0ce00e9247591e65a168232
--- /dev/null
+++ b/output/text/d3fb9fd0-8c83-4670-aefc-d5d9b5b7ec9f.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:B2314041-3E85-4E3F-8924-39FC285808B2 Redacted Final Diagnosis Breast, left, simple mastectomy: Infiltrating pleomorphic lobular carcinoma with focal signet ring cell features, Nottingham grade II (of III) (tubules 3/3, nuclei 2/3, mitoses 1/3; Nottingham. score 6/9], forming a mass (9.2 x 4.2 x 3.2 cm) located in the central region of the breast with a separate nodule (0.8 x 0.7 x 0.6 cm) located adjacent to the main mass on the inferior aspect [AJCC pT3]. Lobular carcinoma in situ is present within and outside the invasive component (0.6 cm in greatest dimension). Angiolymphatic invasion is absent. The non-neoplastic breast parenchyma shows proliferative fibrocystic changes. Calcifications are present in benign ducts. and acini. The tumor does not involve the nipple, skin, or underlying chest wall. All surgical resection margins, including the deep margin, are negative for tumor (minimum tumor free margin, 0.4 cm, deep margin). Sentinel lymph nodes; left axillary Nos. 1, 2, 3, and 4, sentinel biopsy: Multiple (4) left axillary sentinel lymph nodes without blue dye are negative for metastatic carcinoma [AJCC pN0 (i-) (sn)]. Immunohistochemical cytokeratin stain was performed on the paraffin embedded sentinel lymph node tissue and confirms the H&E impression. Her-2/Neu has been ordered on paraffin-embedded tissue. 1cs-0-3 carcnomr, nfiktnatm1(ptumnphu'c) lobwav 852o|3 Sit Suast Nos e 50.9 h 9/2/1
\ No newline at end of file
diff --git a/output/text/d40990ba-be3d-4231-a0a3-ce97609c6a9f.txt b/output/text/d40990ba-be3d-4231-a0a3-ce97609c6a9f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7c60bb403abfdae3335ac9894849d6a544e0244b
--- /dev/null
+++ b/output/text/d40990ba-be3d-4231-a0a3-ce97609c6a9f.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:5F38424F-73C9-41F5-B183-6A812A65593A TCGA-OR-A5LE-01A-PR Redacted tcD-o-3 Carcinonc, adrera! cotiia) 837o|3 Procedure: L adrenalectomy and regional LN. Si+e Adenol Chrd.cor+ex Gross description: 17 x 15 x 15cm, 820g C 74t Z Diagnosis: adrenocortical carcinoma, LN negative for tumor Reference Pathology: Diagnosis: adrenocortical carcinoma, Kl67 2% Weiss score: 5 Hough score: 2.6. Van Slooten score: 19.7
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diff --git a/output/text/d4149eca-1b1d-44c3-918f-dde288db7765.txt b/output/text/d4149eca-1b1d-44c3-918f-dde288db7765.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8bda487b5531fd28a5b2bee0b5ae21a1ba516e24
--- /dev/null
+++ b/output/text/d4149eca-1b1d-44c3-918f-dde288db7765.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UUID:953ADB1E-77C9-4721-B624-F9CCF040575F TCGA-C8-A3M7-01A-PR Redacted Form Revised Clinical Case Report 1cD-0-3 (For Collection of Cancerous Tissue) cmcnma,infAnuHyj Iabulxv, NoS 85S0f3 Site: brst nos c50.9 lw 117 Informed Consent I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the ; RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the. consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator. Signature Date Clinical Information ACAZSSGENERALINFORMATIONSTR Date of Birth (mm/dd/yyyy) Height Marital Status Rare Temperature 1.60 nj  Single Married 3joe Gender Weight  Divorced  Widow  Blood Pressure Heart Rate YFemale 45 6  Male J208o mm1hg P PAHISTORYOFPRESENTIELNESSST. Chief Complaints: Hx ky+ b3ornt Symptoms: hn i the lyf h9eat h 2b Dhhe Whiy' nvnded ho he shiz: Performance Scale (Karnofsky Score):  100 Asymptomatic  80-90 Symptomatic but Fully Ambulatory  60-70 Symptomatic, in bed less than 50% of day.  40-50 Symptomatic, in bed more than 50% of day, but aot bed ridden. 20-30 Bed Ridden :MCURRENTMEDICATIONS Dose Frequency Date (mm/dd/yyyy) Drug Route To / To To To To
+
+--- Page 2 ---
+ PAST MEDICAL HISTORY. Status  Diagnosis Date Treatment Diagnosis/Disease/Disorder/Injury RMMOBGYNHISTORYS.A # of Pregnancies Date of First Menses Menopausal Status yesry rr  Pre-menopausal # of Live Births Date of Last Menses  Peri-Menopausal yenssol  Post-menopausal  Hormone Replacement  Oral Contraceptive   IUD Birth Control:   Condom Therapy:  Other: NO Environmental Hazards: Occupation: Smoking History Duration When Quit  Packs/day Current Status TYPE (yrs) (yr)  yes tNO Alcohol Consumption  Duration When Quit TYPE  Drinks/day Current Status (yr) (yrs)  yES NO Drug Use Duration When Quit  TyPE Frequency Current Status yt (yrs)  yes  nO .. AFAMIEYMEDICALHISTORY Age of Diagnosis  Diagnosis Relative Ceuiies SLABDATA Date Test  Result  Result Date Test CEA   Negative  Positive: HIV Negative  Positive:  CA 15-3  Negative  Positive: Hep B Negative  Positive:   Negative  Positive:  CA 19-9  Negative  Positive:  Hep C   Negative  Positive: PSA   Negative  Positive: AFP Other:  Negative  Positive: Other:   Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+.. *SDIAGNOSTIC STUDIESCMRS: Study Results Date Ultrasound X-Ray cT Endoscopy MRI Biopsy : MWSSCLINICALDIAGNOSISR Preoperative Clinical Diagnosis erf b<eant Caielr Location of Suspected Involved Lymph Nodes Location of Suspected Distant Metastasis Axilla N 0 Clinical Staging Date of Diagnosis NI MO Ts Stage: Treatment Information ASEIACPSSURGICAL TREATMENTMMMSAKAH Procedure Date of Procedure Swer Prihary Tumor Organ Detailed Location Size Dseast 9.Sx wyper -nto qonlraut x. cm Extension of Tumor. Slis Lymph Nodes Location of Lymph Nodes. # of Lymph Nodes Description Palpable, Non-Dissected Lymph Nodes Axilla 6 Dissected Lymph Nodes Distant Metastasis.  Organ Detailed Location  Size N Surgical Staging Nn Mo Stage: ACR T4 NEOADJUVENTTHERAPY (Chemo Radiation ImmunoHormonal,or Molecular  Date (mm/dd/yyyy) Drug/Treatment Dose Route Frequency 1 To 1 To NO To / / To To 1 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Date: Time: Collected by:  Time: Date Preserved by: SPECIMENTYPE (#of samples provided) Slide  Paraffin Block  Blaad/Serum/Plasma Frozen Diseased Normal Diseased Normal Diseased Normal Diseased  Normal P Time to LN2 Time to LN2 Time to Formalin min  6o 10 min  min PATHOLOGICALDESCRIPTION Primary Tumor Extension of Tumor Distance to NAT Size Organ. 2 19.5x cm Rgeat cm Lymph Nodes # Examined # Metastasized Location 6 Axills Distant Metastasis Size Detailed Location Organ NO Pathological Staging M o Stage: pT 4 N o Notes: 4
+
+--- Page 5 ---
+COnSOLIDATED DIAGNOSTIC PATHOLOgy FORm* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION Diffuse + : STRUCTURAL PATTERN x  Streaming + Mosaic x Necrosis  Storiform X] Fibrosis  Lymphocytic infiltration Vascular Invasion Palisading XCystic Degeneration Clusterized Alvcolar Formation Blceding XMyxoid Change Indian File XPsammoma/Calcification 2. Ceilular features: Squamous + Adenomatous + Sarcomatous + Lymphomatows Squamoid Cell Glandular cell  Round Cell Spindle Cell Large Cel! . Cell Stratification Fibroblast Small Cell Keratin  Secretion Osteoblast RS CeIV/RS Like  Desmosome Intracyt. Vacuole Y Lipoblast  Inflam. Cell Pear!  Gland formation <Myoblast Plasma Cel! Otherwise Specified: D, 787. Dr 70Z 7D 60Z Du 7o 2.  Cellular Differentiation: Well Moderatcly Poor Nuclear Atypia: Nuclear Appearance Aniso Nucleosis Hyperchromatism  Nucleolar Prominentd Multinucleated Giant Cell 4 Mitotic Activity Nuckear Grade Histological Diagnosis: Lng(tsatsng Lnbs(as Canesnang, G ) Comments: Date Director, Research Pathology PATHOLOGIST STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CONTRISUTOR AND
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diff --git a/output/text/d41d1218-6cb7-412e-a1df-74b487b4b549.txt b/output/text/d41d1218-6cb7-412e-a1df-74b487b4b549.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4196c7770ef52272462660a1b6286f472252c4a8
--- /dev/null
+++ b/output/text/d41d1218-6cb7-412e-a1df-74b487b4b549.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+TSS iD 1cs.0-3 SPECIMENS: A. SLN #1 RIGHT AXILLA B. RIGHT BREAST Sih: brast, Nos C 50.9 C. ADDITIONAL ANTERIOR MARGIN M SPECIMEN(S): UUID:A9D36308-DAEF-48B9-A4EC-689824EE3DC2 A. SLN #1 RIGHT AXILLA TCGA-E2-A1IO-01A-PR B. RIGHT BREAST Redacted C. ADDITIONAL ANTERIOR MARGIN INTRAOPERATIVE CONSULTATION DIAGNOSIS: TPA, Lymph node, sentinel, right axilla, biopsy: Negative for carcinoma. Part B, Right breast, Gross examination: Tumor is present at the anterior margin, and at least 0.2-cm from posterior margin Diagnoses called at .(A) anc B) by Dr. GROSS DESCRIPTION: A. SLN #1 RIGHT AXILLA Received fresh labeled with the patient's patient and designated "sentinel lymph node number one right axilla" is a fragment of lymphoid tissue measuring 1.9 x 1.2 x 0.8 cm. Touch preparation is performed. Entirely submitted, A1. B. RIGHT BREAST Received fresh labeled with the patient's identification and designated "right breast" is a previously inked, oriented, 13-g, 4 x 2.5 x 1.5 cm lumpectomy specimen. The short suture designates superior, long-lateral. Ink code: Anterior-yellow, posterior-black, medial-green, lateral-red, superior-blue, inferior- orange. The specimen is serially sectioned from medial to lateral into 6 slices revealing a firm tan mass, 1.2 x 0.9 x 0.7 cm, located 0.1-cm from the nearest anterior margin. A portion of the specimen is submitted for tissue procurement. The remainder of the specimen is entirely submitted: B1-B2: Perpendicular sections medial margin. B3-B4: Slice 2, B4 demonstrates mass B5-B6: Slice 3, B6 demonstrates mass B7-B8: Slice 4, B8 demonstrates mass B9-B10: Slice 5, B10 demonstrating remainder of mass B11-B12: Perpendicular sections lateral margin. C. ADDITIONAL ANTERIOR MARGIN Received fresh labeled with the patient's identification and designated "additional anterior margin" are two previously inked (black at final margin) fragments of adipose tissue together weighing 1 g and measuring 2 x 1 x 0.3 cm in aggregate. The entire specimen is submitted, C1. DIAGNOSIS: A. LYMPH NODE, SENTINEL #1, RIGHT AXILLA, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1). B. BREAST, RIGHJ, WIDE LOCAL EXCISION: - INVASIVE DUCTAL CARCINOMA, SBR GRADE 3 WITH FOCAL NECROSIS, MEASURING 1.2-CM - HIGH NUCLEAR GRADE, DUCTAL CARCINOMA IN SITU, SOLID AND CRIBRIFORM TYPES WITH CENTRAL NECROSIS, MICROCALCIFICATIONS, AND LOBULAR EXTENSION - INVASIVE TUMOR INVOLVES ANTERIOR SURGICAL RESECTION MARGIN (SEE PART C) - BIOPSY SITE CHANGES WITH FIBROSIS - SEE SYNOPTIC REPORT. C. BREAST, ADDITIONAL ANTERIOR MARGIN, EXCISION: - FATTY BREAST TISSUE, NO TUMOR SEEN. SYNOPTIC REPORT - BREAST Specimen Type: Excision Needle Localization:  No Laterality:  Right  Invasive Tumor: Present Multifocality: No  WHO CLASSIFICATION
+
+--- Page 2 ---
+TSS ID Invasive ductal carcinoma, NOS 8500/3 Tumor size: 1.2cm Margins: Negative Distance from closest margin: 0.3cm inferior Tubular Score: 3 Nuclear Grade: 2 Mitotic Score: 3 Modified Scarff Bloom Richardson Grade: 3 Necrosis: Present Vascular/Lymphatic Invasion:  None identified Lobular neoplasia: None Lymph nodes: Sentinel lymph node only Lymph node status: Negative 0/1 DCIS present  Margins uninvolved by DCIS DCIS Quantity: Estimate 10% DCIS Type: Solid Cribriform DCIS Location: Associated with invasive tumor Nuclear grade: High Necrosis: Present Location of CA++: DCIS Benign epithelium ER/PR/HER2 Results ER: Positive PR: Positive HER2: Pending Performed on Case: Pathological staging (pTN): pT 1c N 0 Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition CLINICAL HISTORY:  None given PRE-OPERATIVE DIAGNOSIS: None given ADDENDUM: SYNOPTIC REPORT - BREAST HER-2 RESULTS Specimen: Surgical Excision Block Number: Interpretation: EQUIVOCAL Intensity: 2+ % Tumor Staining: 30% Fish Ordered: Yes METHODOLOGY:  Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Her? analvsis.was performed using the FDA approved Dako HercepTest (TM) test kit 1) using rabbit anti-human HER2. This assay was not modified. External kit-slides provided by the manufacturer (cell lines with high, low and negative HER2 protein expression) and in- house known HER2 amplified control tissue were evaluated along with the test tissue. Adequate, well preserved, clear-cut invasive carcinoma was identified for HER2 evaluation. Interpretation of the HER2 immunohistochemical stain is guided by published results in the medical literature, information provided. by the reagent manufacturer and by internal review of staining performance.
+
+--- Page 3 ---
+TSS ID Department takes full responsibility for this test's performance. PathVysion HER-2 DNA Probe Kit Case No Analytical Interpretation of Resuits: HER-2 NOT AMPLIFIED Clinical Interpretation of results Amplification of the HER-2 gene was evaluated with interphase fluorescence in-situ. hybridization (FiSH) on formalin-fixed paraffin embedded tissue sections using a chromosome 17 centromeric probe and a HFR-2 probe that spans the entire HER-2 gene in the F ' by Dr :. A majority of tumors cells displayed moderate polysomy 17 with 2 to 4 chromosome 17 signals and 2 to 4 HER-2 signals, with a HER-2/CEP 17 Ratio </=2.0, consistent with no amplification of the HER2/neu gene. Block used Source of case: Tissue fixation formalin-fixed tissue Outside Case No:NA Tissue source breast Results interpreted: HER2/CEP17 ratio: yes 1.1 This ratio is derived by dividing the total number of LS! HER-2/neu signals by the total number of CEP17 signals in at least 20 interphase nuclei with nonoverlapping nuclei in the neoplastic  mammary epithelial cells. Cells with no signals or with signals of only one color are disregarded. Method of ratio enumeration: manual count. Limitations The Vysis PathVysion Kit is not intended for use to screen for or diagnose breast cancer. It is intended to be used as an adjunct to other prognostic factors currently used to predict disease-free and overall survival in stage li, node-positive breast cancer patients. In making decisions regarding adjuvant CAF treatment, all other available clinical information should also be taken into consideration, such as tumor size, number of involved lymph nodes, and steroid receptor status. No  treatment decision for stage II, node-positive breast cancer patients should be based on HER- 2/neu  gene amplification status alone. Overview of this test FDA APPROVED REAGENT  PathVysion HER-2 DNA Probe Kit is FDA approved for selection of patients for whom Herceptin therapy is being considered. These tests were performed. of Dr.. The results of these studies should always be interpreted in the context of the. clinical, morphological, and immunophenotypic diagnosis. ONCOTYPE DX BREAST CANCER ASSAY RESULTS: Recurrence Score: 18 CLINICAL EXPERIENCE: Patients with a recurrence score of: 18 in the clinical validation study had an average rate of Distant Recurrence at 10 years of 11% ER Score: 10.2Positive PR Score: 9.2 Positive Her2 Score: 9.9 Negative Interpretation: ER Negative < 6.5  Positive >= 6.5 PR Negative < 5.5 Positive >= 5.5 Her2 Negative <10.7  Positive >=11.5 Equivocal = 10.7 - 11.4 Gross Dictation:,  Microscopic/Diagnostc Dictation:, Final Review: M.D., Pathologist. Final: M.D., Pathologist, Addendum:  M.D., Pathoiogist, Addendum Final:  M.D., Pathologist, (. Addendum:, M.D., Pathologist, Addendum Finai, M.D., Patholuyist, Addendum, M.D., Pathologist Addendum Final:, M.D., Pathoiogist,
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diff --git a/output/text/d4424a60-c867-4d6b-aacc-157c62b12239.txt b/output/text/d4424a60-c867-4d6b-aacc-157c62b12239.txt
new file mode 100644
index 0000000000000000000000000000000000000000..455df7d0cc9eee08c89cd7f287d37ca975a56297
--- /dev/null
+++ b/output/text/d4424a60-c867-4d6b-aacc-157c62b12239.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TSS ID TSS ID: . - Oc id:. -- Date of Procurement Gross Description: Microscopic Description: Diagnosis Details: Comments: Formatted Path Report: BREAST TISSUE CHECKLIST /cs-0-3 Specimen type: Mastectomy Sip: bresst nos c5o.9 4/8/11 h Specimen size: Not specified Tumor site: Breast Tumor size: 2 x 1.5 x 1.5 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinomae Histologic grade: Moderately differentiated Tumor extent: Not specified  Lymph nodes: 1/12 positive for metastasis (Axillary 1/12) Extracapsular invasion of the lymph nodes: Not specified Margins: Not specified Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified UUID:DD0ADC20-2059-435E-9EB4-351C87D7CBEB TcgA-E9-A1R0-01a-Pr Redacted Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified. Additional pathologic findings: Not specified. Comments: None
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diff --git a/output/text/d472c0e2-11bb-4c80-ab04-2f7dc9222eab.txt b/output/text/d472c0e2-11bb-4c80-ab04-2f7dc9222eab.txt
new file mode 100644
index 0000000000000000000000000000000000000000..26a2f0634fe0c001596039c9eb4ea3dc664956e1
--- /dev/null
+++ b/output/text/d472c0e2-11bb-4c80-ab04-2f7dc9222eab.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+FINAL DIAGNOSIS: BREAST, LEFT, mOD!FIeD RADiCAL MASTECTOmY AND AXILLARY DISSECTiON -- A. inFILtraTIng DUcTal CARcInomA : NOTTINgHam SCORE: 8/9 (tOBULeS - 3, nUCLeI - 3, mITOSES - 2). ) (see comment). B. C. LYMPHOVASCULAR PERMEATION IS PRESENT. D. DUctAl CArcinOma In SitU, SOLiD And CribrIfOrm types, nucLear graDe 3, with COmedO NECROSIS, ASSOCIATED MICROCALCIFICATION AND RETROGRADE CANCERIZATION OF LOBULES, REPRESENTING LESS THAN 1% OF TUMOR VOLUME. DUCTAL CARCINOMA IN SITU iS PRESENT ADMIXED WITH THE INVASIVE TUMOR. E. MARGINS OF RESECTIOn AND SKELeTAl MUSCLE ARE fREE OF TUmOR. F. Nipple, free of tumor. G. SKin wIth AcROchOrdOn (FiBROepitHeLiAL POLyp), nO tumOR SEen. H. ChAngES COnSISTenT wIth PreVIOUS BiOpSy SITE, SEe PRIOR I. FIBROCYSTIC CHANGES WITH DUCTAL EPITHELIAL HYPERPLASIA AND COLUMNAR CELL CHANGES. J. IMMUNOHISTOCHEMICAL STAININGS FOR ESTROGEN RECEPTOR, PROGESTERONE RECEPTOR WERES PREVIOUSLY PERFORMED ON AnD WERE REPORTED AS FOLLOWS: ESTROGEN RECEPTOR -- POSITiVE, pROgESTeROne RECEpTOR - POSITIVE, AnD hER-2/neu - NEgATiVe (SCORe: 1+). K. METASTATIC ADENOCARCINOMA iNVOLVING ONE OUT OF TWENTY-THREE (1/23) LEFT AXILLARY LYMPH NODES. UP TO 1.1 CM (SS, TT, and UU), SEE PRIOR LEFT AXILLARY FINE NEEDLE ASPiRATION CYTOLOGY (see comment).. CAse stnupsis. SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST LATERALITY: PROCEDURE: Left Modified radical mastectomy LOCATION: Not specified SIZE OF TUMOR:  Maximum dimension invasive component: 8.3 cm.  MULTiCENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: No TUMOR TYPE (invasive component): 1cs-0 -3 Ductal adenocarcinoma, NOS NOTTINGHAM SCORE: Nuclear grade: 3 Carciioma, nfithatmg ductd, nos 8500/3 Tubuie formation: 3 Sih:busst,Nos C50,9 3f3/n pu Mitotic activity score: 2 Total Nottingham score: 8 Nottingham grade (1, 2, 3): 3 ANGIOLYMPHATIC INVASION: Yes DERMAL LYMPHATIC INVASION: No CALCIFICATION: Yes, malignant zones Tumor type, in situ: Cribriform Solid DCIS admixed with invasive carcinoma Percent of tumor occupied by in situ component: 1 %. SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: SURG MARGINS iNVOLVED BY IN SITU COMPONENT: No Critaris PAGET'S DISEASE OF NIPPLE: No Diagosis Discrcpan LYMPH NODES POSITIVE: No HIPAA Discrepar LYMPH NODES EXAMINED: 1 METHOD(S) OF LYMPH NODE EXAMINATION: 23 Case is (zircle): Reviewer nitiis  SIZE OF NODAL METASTASES HE stainr 3/13/+1) NON-NEOPLASTIC BREAST TIS Diametor.oflarg hnode metastasis: 11 mm t Stage, pathologic... N StagE, PatholoOgIc: M Stage, PathologiCA. ESTROGEN RECEPTORSA PROGESTERONE RECEPTOR HER2/NEU: UUID:1856E5A6-3588-4C60-8BC5-68716C946799 TCGA-BH-A0BZ-01A-PR Redacted
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diff --git a/output/text/d4883b16-0957-4284-b8fb-1b6d8f9eec19.txt b/output/text/d4883b16-0957-4284-b8fb-1b6d8f9eec19.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5f0df74a3d576d38a626da247d0986e35ed5e3d6
--- /dev/null
+++ b/output/text/d4883b16-0957-4284-b8fb-1b6d8f9eec19.txt
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+
+--- Page 1 ---
+PATIeNT HISTORy: PRE-OP DIAGNOSIS: Colon cancer. POST-OP DIAGNOSIS: Same, PROCEDURE: Sigmoid colon, resection.. FinAl DIAgnOSiS: Collection Date: Part 1: bLaDDer wall, Excision -- POsItive for ADenocarcinoma, ExtenDiNg To Cauterized Specimen edgeS. parts 2 And 4: sigmoid colon, sigmoidectomy -- A. mODerATeLy DIfFEREnTIaTeD ADeNOcArcinomA (4.5 Cm) InVOLViNg COLONIc WALL TRAnSmuRALLY (see comment). B. BOTH ANGIOLyMphaTIC AND PERiNeURAl iNVASION IDeNTIFIeD. C. PROXimAl AND DISTAl SUrGICaL MARGINS FREE OF CARCINOMA. D. CArCiNOmA IS prESENT ON SEROSAL SUrFACE AnD AT CAUTERIzeD RADIAL eDgE OF SPEcImEn. E. METASTATIC ADENOCARCINOmA In fIVE OF nInetEeN Lymph NODeS (5/19). Part 3: Left pelvic sidewall, Biopsy - POSITIVE FOR ADENOCARCINOMA, EXTENDING TO CAUTERIZED SPECIMEN EDGES. PaRt 5: Omentum, ExcisiOn - POSITIVE FOR ADENOCARCINOMA. COMMENT: The carcinoma extensively involves the colonic wall, from the mucosa to the pericolic adipose tissue, but no definite. precursor lesion is seen in the colonic mucosa. There is extensive, plaque-like extramural/subserosal involvement as well, with areas of serosal penetration and at least one focus where cauterized carcinoma is present at what appears to be the radial and/or mesocolic specimen edge. This corresponds to the operative report describing dense tumor infiltrating the pelvic sidewall over the iliac vessels, through which the surgeon cut. In addition, immunohistochemical stains reveal the carcinoma to be strongly positive for cytokeratin 7 with only focal positivity for cytokeratin 20. CDX-2 is. completely negative, as are TTF-1 and PsA. CEA and cytokeratin 19 are positive. Positive immunostains for the DNA mismatch repair proteins MLH-1, PMS-2, MSH-2 and MSH-6 reveal preserved nuclear expression. In summary, the overall. morphoiogical findings and immunohistochemical profile are not typical of a primary colorectal adenocarcinoma. A possible primary site compatible with the immunomorphological findings is the pancreaticobiliary system. Alternatively,. if another potential primary site cannot be found clinically, this could be a primary peritoneal adenocarcinoma with extension into the colonic wall. Finally, the lymph node total includes one lymph node confirmed to be negative for carcinoma by a negative cytokeratin AE1/AE3 immunostain.
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diff --git a/output/text/d49ca1d3-aa83-40c3-b4c7-edf629f85eba.txt b/output/text/d49ca1d3-aa83-40c3-b4c7-edf629f85eba.txt
new file mode 100644
index 0000000000000000000000000000000000000000..44b6d86c2a7a28a6441de34d6efbf95dcfc2ba62
--- /dev/null
+++ b/output/text/d49ca1d3-aa83-40c3-b4c7-edf629f85eba.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+FINAL DIAGNOSIS: Part 1: Lymph nOde, Left AxIlLAry SentInel nOde #1, BIOpSy - TWO SENTINEL LyMPH NODES, NEGATIVE fOR CARCinOMA (0/2). Part 2: Lymph nOde, Left AxilLary Sentinel nOde #2, biOpsy -- TWO SENTINEL LYMPH NODES, NEGATIVE FOR CARCINOMA (0/2). Part 3: breast, Leet, 12 O'clOck Segmental mastectomy - A.  INFILTRATiNG MAmmARY CARCiNOmA, WITH MIXEd DUcTAL AND LOBULAR PHenOtyPES, nOTTInGhAm GraDe 2/3 (tubuLe fOrmAtiOn: 3, nuClEAr PLeOmOrphISm: 3, mITOtic AcTiVIty: T, TOtal SCORe: 7/9). B. THE INVASIVE CARCINOMA MEASURES 1.9 CM IN GREATEST DIMENSION (GROSS MEASUREMENT). c. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 2, SOLiD TYPE. D. DCIS CONSTITUTES LESS THAN 5% OF THE TOTAL TUMOR MASS, AND IS PRESENT ADMIXED WITH THE INVASIVE CARCINOMA. E. SURGICAL MARGINS ARE NEGATIVE FOR INFILTRATING CARCINOMA AND DCIS. INFILTRATING CARCINOMA IS 0.3 CM FROM THE CLOSEST POSTERIOR MARGIN (31). F.  NO LYMPHOVASCULAR INVASION IDENTIFIED.S G.  FOcAl Ductal epithelial hyperplAsiA. H. PREVIOUS BIOPSY SITE CHANGES. FIBROCYSTIC CHANGES WITH APOCRINE HYPERPLASIA AND SCLEROSING ADENOSIS. J.  IMmunOStAIN FOR eStROgeN RECEptOR IS POsItivF prnrcctcDAue CASE SYNSPSYS: SYNOPTIC - PRIMARY iNVASIVE CARCINOMA OF BREAST LATERALITY: Left PROCEDURE: Segmental LOCATION: Upper outer quadrant SIZE OF TUMOR:  Maximum dimension invasive component: 1.9 cm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:  No TUMOR TYPE (invasive component): Ductal adenocarcinoma, NOs, Infiltrating lobular carcinoma HISTOLOGIC TYPE: Classical NOTTINGHAM SCORE: Nuclear grade: 3 1Cs-0-3 Tubule formation: 3 ChrcuDmn, nfi{t7sHng duchl nd 1o6ulw,Nt3 Mitotic activity score: 1 Total Nottingham score: 7 85os{3 Nottingham grade (1, 2, 3): 2 Sih;brust,nos c50.9 3/13fu h~ ANGIOLYMPHATIC INVASION: No DERMAL LYMPHATIC INVASION: Not applicable CALCIFICATION: No TUMOR TYPE. IN SITU: Solid, DCiS admixed with invasive carcinoma SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:E No SURG MARGINS INVOLVED BY IN SITU COMPONENT: No LyMPH NODES POSITIVE: 0 LYMPH NODES EXAMINED: 4 METHOD(S) OF LYMPH NODE EXAMINATION: UUID:3A54CF6E-AFDB-4609-A827-77D75BB376A7 Redacted tcGA-bh-A0C3-01A-PR H/E stain SENTINEL NODE METASTASIS: No NON-NEOPLASTIC BREAST TISSUE: FCD T STAge, PAtHOlOgIC: pT1c N STage, PAtholOgIC: pN0 M Stage, pathologic: pMX ESTROGEN RECEPTORS:  positive PROGESTERONE RECEPTORS: negative zero or 1+ The invasive carcinoma show features of lobular carcinoma in H&E sections. The immunohistochemical stains for E- cadherin and P120 indicate that some tumors cells show the patten of ductal carcinoma (membranous stains for E- cadherin and P120), and some tumors show the pattern of lobular carcinoma (weak stain for E-cadherin and strong and  diffuse cytoplasmic stain for P120. mary Tumor Site screpancy s (circle):
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diff --git a/output/text/d4cd4299-2367-4909-9a65-08da4c775d74.txt b/output/text/d4cd4299-2367-4909-9a65-08da4c775d74.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e1db18754631bf73ffd160c8e2f9adec92cbf86c
--- /dev/null
+++ b/output/text/d4cd4299-2367-4909-9a65-08da4c775d74.txt
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+
+--- Page 1 ---
+SPECIMEN A. Omentum. B. Right colon. CLINICAL NOTES PRE-OP DIAGNOsIS: Right colon cancer FROZEN SECTION DIAGNOSIS A - Benign fibromembranous and adipose tissue. A 4 mm stone is also present. GROSS DESCRIPTION A. Received fresh for frozen section labeled "omentum." It consists of a portion of soft glistening pink fibrofatty tissue measuring 2.4 x 1.2 x 0.8 cm. On section it is soft and pink. There is a 0.4 cm. hard yellow stone embedded within the tissue. The entire specimen ex. r the stone is submitted in one block. for frozen section. B. The specimen consists of a "right colon" which is partially covered with pink-tan smooth glistening serosa and abundant yellow lobular fat. There is a long suture marking the right colic and ileocolic pedicles. The specimen is stapled at both ends.  The specimen is predominantly covered with pink-tan smooth glistening serosa with abundant yellow lobular fat. The small bowel is 5.5 cm. long and the colon is 36 cm. long. The specimen is open and partially filled with dark bloody brown diffluent fecal material. The mucosa of the small bowel is smooth glistening having a circumference of 3.5 cm. There is an appendix present which is 6.0 x 0.7 cm. The colonic mucosa is pink-tan, smooth glistening and edematous showing multiple lesions. There is a 3.7 x 3 x 0.5 cm. ulcerated tumor located 4.5 cm. distal from the ileocecal valve. It is likely it extends through the muscularis propria, coming within 0.7 cm. of the radial margin. This tumor mass is 27.8 cm. from the
+
+--- Page 2 ---
+GROSS DESCRIPTION distal margin. A sample is taken for tissue procurement..  There is also a large sessile exophytic polyp which is 5.5 x 3.5 x 3.0 cm. This comes within 18 cm of the distal margin. There are a few additional polyps grossly identified, one on the ileocecal valve and others toward the distal end. These average 0.5 cm. to 1.0 cm. in greatest dimension and show no discrete invasions grossly identified in the large polyp previously described. Multiple lymph nodes grossly identified in the fat. Representative sections of the specimen are submitted as follows: Block 1 - Representative luminal. margin; block 2 - ileocecal valve with polyps; block 3 - entire appendix, proximal end inked; blocks 4-6 - Representative section of tumor to radial margin, ends normal; blocks 7, 8 - additional polypoid lesions toward distal end, full thickness; blocks 9-12 entire polypoid lesion full thickness; block 13 - ileocolic pedicle, block 14, additional tied off pedicle located distally; block 15 - three possible lymph nodes; block 16 - four possible lymph nodes; block 17 - four possible lymph nodes; block 18 - four possible lymph nodes; block 19 - four possible lymph nodes; block 20 - one possible lymph node. RS-20 MICROSCOPIC DESCRIPTION A. Micro A performed. B. Multiple lesions are present within the right colon,. one of which is an ulcerated adenocarcinoma. Please see. the template below. Histologic type: Infiltrating adenocarcinoma. Histologic grade: Moderately differentiated. Primary tumor (pT): The tumor minimally extends into pericolonic. fat, pT3. Proximal margin: Negative for tumor. Distal margin: Negative for tumor.
+
+--- Page 3 ---
+MICROSCOPIC DESCRIPTION Circumferential (radial) margin: Negative.. Distance of tumor from closest margin: 27.8 cm from the distal margin Vascular invasion: Negative. Regional lymph nodes (pN): All 21 regional lymph nodes are negative for metastatic disese, 0/21, pN0. Non-lymph node pericolonic tumor: None.. Distant metastasis (pM): Cannot be assessed.. Other findings: Within the right colon, there is a large sessile tubulovillous adenoma. Additional smaller polyps are noted including two adenomas and one hyperplastic polyp. Appendix, no significant pathology.. 3, 14, 5 DIAGNOSIS A. Omentum, small excision - Benign fibroadeipose tissue with stone. B. Right colon, right hemicolectomy - Infiltrating moderately differentiated adenocarcinoma of the right colon, extending into pericolonic fat, pT3. All 21 lymph nodes negative for metastatic disease. All margins negative for tumor.. Large sessile tubulovillous adenoma, also present as well as two much smaller adenomatous polyps and one hyperplastic polyp. - End Of Report.
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diff --git a/output/text/d4df6379-9706-4b3f-99d0-adfa8d7383f6.txt b/output/text/d4df6379-9706-4b3f-99d0-adfa8d7383f6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f593ae094fb0e0bd090c8fad216df9395457db35
--- /dev/null
+++ b/output/text/d4df6379-9706-4b3f-99d0-adfa8d7383f6.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:9FB40DC5-BED9-420E-B334-4D0BE8B8BCF5 TCgA-Ew-A6SD-01a-Pr Redacted Surgical Pathology Report Name: xx Case #: x DOb: Collected: Gender: F Received: x  MrN: xxx Reported: Location: xx Physician: xxx Pathologic Interpretation: A. Left Breast Lumpectomy: INVASIVE DUCTAL CARCINOMA, poorly differentiated, Nottingham grade 3 (3+3+3=9), 2.1 cm in greatest dimension. Resection margins are free of tumor; closest is inferior, 0.1 cm. B. LEFT AXILLARY CONTENTS: METASTATIC DUCTAL CARCINOMA to two out of twenty-six lymph nodes (2/26) with extranodal extension. tD-0-3 C. ADDITIONAL LEFT AXILLARY CONTENTS LEVEL 2-3: acinona,iryiltatiry dluct No malignancy seen in five lymph nodes (0/5). 85d6/3 Surgical Pathology Cancer Case Summary Site Oy Bsosh, NOS C50.9 Specimen: Partial breast Procedure: Excision without wire-guided localization J 7k 4/L3 Lymph Node Sampling: Axillary dissection (partial or complete dissection) Specimen Integrity: Single intact specimen (margins can be evaluated). Specimen Laterality: Left Tumor Size: Size of Largest Invasive Carcinoma: Greatest dimension of largest focus of invasion over 0.1 cm: 2.1 cm Additional dimensions: 1.7 x1.7 cm Tumor Focality: Single focus of invasive carcinoma Macroscopic and Microscopic Extent of Tumor: Skin: Skin is not present Skeletal Muscle: No skeletal muscle present Ductal Carcinoma in Situ (DCiS): DCIS is present Architectural Patterns: Solid Nuclear Grade: Grade III (high) Histologic Type of Invasive Carcinoma: Invasive ductal carcinoma (no special type or not otherwise specified) Histologic Grade: Nottingham Histologic Score: Glandular (Acinar)/Tubular Differentiation.  Score 3: < 10% of tumor area forming glandular/tubular structures Nuclear Pleomorphism Score 3: Vesicular nuclei, often with prominent nucleoli, exhibiting marked variation in size and. shape, occasionally with very large and bizarre forms
+
+--- Page 2 ---
+Mitotic Count Score 3 Overall Grade Grade 3 Margins:  Margins uninvolved by invasive carcinoma Distance from closest margin: 1 mm (inferior). Margins uninvolved by DCIS Lymph Nodes: Number of sentinel lymph nodes examined: 0 Total number of lymph nodes examined (sentinel and nonsentinel): 31 Number of lymph nodes with macrometastases (> 0.2 cm): 2 Largest metastatic deposit: 3.0cm Extranodal Extension: Present Method of Evaluation of Sentinel Lymph Nodes: Hematoxylin and eosin (H&E), one level Pathologic Staging (pTNM): Primary Tumor (pT): pT2: Tumor > 20 mm but s 50 mm in greatest dimension Regional Lymph Nodes (pN): pN1a: Metastases in 1 to 3 axillary lymph nodes, at least 1 metastasis greater than 2.0 mm Distant Metastasis (pM): Not applicable Ancillary Studies: Estrogen Receptor: Performed on another specimen:. Results: Less than 1% immunoreactive cells present Progesterone Receptor. Performed on another specimen: Results: Less than 1% immunoreactive cells present HER2/neu Immunoperoxidase Studies: Performed on another specimen:. Results: Positive (Score 3+) Clinical History: None Provided Operation Performed Left Breast Lumpectomy Pre Operative Diagnosis: Breast Cancer Specimen(s) Received/Processing Information: Fee Codes: A: LEFT BREAST LUMPECTOMY H&E, Initial x 1, H&E, Initiai x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1 B: LEFT AXILLARY CONTENTS H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1 C: ADDITIONAL LEFT AXILLARY CONTENTS LEVEL 2-3 H&E, Initial x 1, H&E, Initial x 1
+
+--- Page 3 ---
+Gross Description:. A.  Received in formalin is a yellow tan fibrotic adipose tissue fragment weighing 86 grams and measures 8.0 x. 7.0 x 4.0 cm. The specimen is oriented with a long stitch lateral, short superior and double stitch. Inked as follows: Superior in Blue -- deep black, anterior yellow, inferior green, lateral orange and medial red. Cross sections of the specimen shows a firm pale tan well circumscribed mass measuring 2.1 x 1.7 x 1.7 cm. It is.  within 1 mm from inferior resection margin, all additional margins are uninvolved by tumor. The mass shows a metallic clip (previous biopsy site). No additional lesions are grossly present. Sections submitted as. follows: Cassette #1-4  Representative section of the mass with relations to the inferior margin (almost in toto). (Cassette #1) -largest dimension of the mass, (Cassette #4) previous biopsy site Cassette# 5 Superior margin Cassette# 6 Deep margin Cassette# 7 Anterior margin. Cassette#8  Lateral margin Cassette #9  Medial resection margin. B  Received in formalin are multiple yellow tan fibrotic adipose tissue fragments measuring 15.0 x 13.0 x 4.0 cm in aggregate. Twenty-six lymph nodes were grossly identified measuring up to 3.0 x 2.0 cm in greatest dimension. The two largest lymph nodes show a metastatic tumor. Sections submitted as follows:. Cassette #1  Representative section from one large lymph node Cassette #2 Representative section from the second largest lymph node. Cassettes# 3&4 One lymph node in toto per cassette. Cassettes#5-10 Four lymph nodes in toto per cassette. C  Received in formalin is a yellow tan fibrotic adipose tissue fragment. It measures 10. 0 x 6.0 x 2.0 cm in aggregate. The five lymph nodes are grossly identified measuring up to 0.4 x 0.3 cm in greatest dimension. Sections submitted as follows:. Cassette #1 Two lymph nodes in toto Cassette# 2 Three lymph nodes in toto. hA13
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diff --git a/output/text/d4f79419-3295-4783-9770-c74e88a02ff7.txt b/output/text/d4f79419-3295-4783-9770-c74e88a02ff7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..939ccc37d6a689d3ae37accc390649412d599a84
--- /dev/null
+++ b/output/text/d4f79419-3295-4783-9770-c74e88a02ff7.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+DIAGNOSIS (A) RIGHT NECK DISSECTION: Twenty-nine regional 1ymph nodes, no tumor present. Submandibular gland, unremarkable. (B) "MENTAL HYOID MUSCULAR INSERTION": Connective tissue; no tumor present. (C) RIGHT LINGUAL NERVE: Peripheral nerve, no tumor present. (D) ANTERIOR TONGUE,EXCISION: Tongue mucosa and underlying connective tissue; no tumor present.. E) FLOOR OF MOUTH, TONGUE, LINGUAL CORTEX AND NECK DISSECTION: INVASIVE GRADE 2 SQUAMOUS CARCINOMA;RESECTION MARGINS FREE OF TUMOR SEE COMMENT). Thirty-one regional lymph nodes, no tumor present. Submandibular gland with chronic sialoadenitis and atrophy; no. tumor present. (F) "ANTERIOR TONGUE": Squamous mucosa with mild non-specific chronic inflammation; no tumor present.. (G) TEETH: Multiple (two) teeth. (Gross only) (H) "ADDITIONAL ANTERIOR TISSUE" Squamous mucosa; no tumor present. Entire report and diagnosis completed by: Renort released by:. COMMENT The morphological features of this neoplasm are those of a form of moderately. differentiated (grade 2) squamous carcinoma. The bulk of tumor involves the floor of mouth and contiguous tongue. Maximum depth of invasion is 1.8 cm. Peri-neural invasion by tumor is present. No unequivocal 1ympho-vascular invasion by tumor is identified. ' Tumor invades minor salivary gland tissue. The final resection margins are free of tumor. GROSS DESCRIPTION (A) RIGHT NECK DIssEcTION - Multiple lymph nodes, soft tissue and salivary gland (12.0 x 5.0 x 3.0 cm in aggregate).' The submandibular gland is identified in level I (5.0 x 3.0 x 1.0 cm).. Multiple lymph nodes are identified in all levels ranging from 0.3 to 1.2 cm in greatest dimension. Al7 lymph nodes are submitted in toto. SECTION CODE: A1-A4 FVEI
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diff --git a/output/text/d50b4c5e-f81c-42a2-9219-dec03f23f93b.txt b/output/text/d50b4c5e-f81c-42a2-9219-dec03f23f93b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..cd5f6d6e8739aea7851b84e00831f8e37e7cbcd3
--- /dev/null
+++ b/output/text/d50b4c5e-f81c-42a2-9219-dec03f23f93b.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+SURGICAL PATHOLOGY REPORT * Addendum  Clinical Diagnosis  & History: with transverse colon moderately differentiated adenocarcinoma. Specimens Submitted: 1: sp: Right colon, hemicolectomy DIAGNOSIS: 1. LARGE BOWEL; RIGHT HEMICOLECTOMY: TUMOR TYPE: ADENOCARCINOMA. HISTOLOGIC GRADE: MODERATELY DIFFERENTIATED. TUMOR LOCATION: ASCENDING COLON. TUMOR SIZE: LENGTH IS 5.2 CM, WIDTH IS 4.1 CM, AND DEPTH IS O.3 CM. TUMOR INVASION: INVASION INTO MUSCULARIS PROPRIA. GROSS TUMOR PERFORATION: NOT IDENTIFIED. SEROSAL INVOLVEMENT: NOT IDENTIFIED. VASCULAR INVASION: NOT IDENTIFIED. PERINEURAL INVASION: NOT IDENTIFIED. SURGICAL MARGINS (FOR COLONIC TUMORS): FREE OF TUMOR. POLYPS (AWAY FROM THE CARCINOMA) : NOT IDENTIFIED.  OTHER FINDINGS: THE APPENDIX CONTAINS A SMALL INCIDENTAL SCHWANNOMAS 0.5CM. - NON-NEOPLASTIC BOWEL: UNREMARKABLE. THE PATHOLOGIC STAGE IS (AJCC 2002) : pT2. LYMPH NODES: NUMBER WITH METASTASES: 0, NUMBER EXAMINED: 33. THE PATHOLOGIC STAGE IS (AJCC 2002) : pN0. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVEDS THIS REPORT. ** Continued on next page **
+
+--- Page 2 ---
+ Page 2 of 3 1. The specimen is received fresh, labeled "Right colon" and consists of a segment of terminal ileum, cecum with attached appendix and ascending colon. The terminal ileum measures 6 cm in length and 3.5 cm in circumference at the proximal resected margin.. The remaining colon measures 33 cm in length with a circumference of 7 cm at the distal resected margin.  The attached The appendiceal and intestinal serosa is pink tan and smooth.  Focally hemorrhagic lobulated yellow tan adipose tissue spans the length of the specimen measuring up to 3 cm in thickness. Attached unremarkable omental fat measures 18 x 6 x 1.3 cm.  The specimen is opened to reveal a mass lesion measuring 5.2 cm in length and 4.1 cm in width. Sectioning show that the tumor invades into the muscularis. The depth of invasion is 0.3 cm grossly.  The remaining mucosa is grossly unremarkable. Multiple lymph nodes are identified in the attached adipose tissue and are submitted. Representative sections of the specimen are submitted for permanent sections and for TPS. Summary of sections: P-- proximal margin shave D distal margin shave T-- mass A  -- appendix representative sections RS--representative sections O- omental fat LN--  lymph nodes, 17-19 closest to tumor ADD additional sections from tumor area (the tumor is entirely submitted now) Summary of Sections: Part 1: SP: Right colon, hemicolectomy. Block Sect. Site PCs 2 A 2 3 add 3 2 DM 2 8 LN 8 2 0 2 1 PM 1 2 RS 2 4 T 4 ** Continued on next page **
+
+--- Page 3 ---
+Page Addendum Diagnosis. #1) SITE: LARGE BOWEL, RIGHT COLON  IMMUNOHISTOCHEMICAL STAINING FOR DNA MISMATCH REPAIR PROTEINS HAS BEEN PERFORMED. THE RESULTS ARE AS FOLLOWS: MLH1: STAINING PRESENT IN TUMOR MSH2 : STAINING PRESENT IN TUMORS MSH6: STAINING PRESENTS IN TUMOR PMS2 : STAINING PRESENT IN TUMOR CONCLUSION: IMMUNOHISTOCHEMICAL STAINING FOR THE TESTED DNA MISMATCH REPAIR PROTEINS IS RETAINED IN THE TUMOR. Some of the immunohistochemistry and Ish tests were developed and their performance characteristics were determined by the department of pathology.. They have not been cleared or approved by the us food and drug. administration. The FDA has determined that such clearance or approval is. not necessary. These tests are used for clinical purposes. They should not. be regarded as investigational or for research. This laboratory is certified. under the clinical laboratory improvement amendments of as qualified to perform high complexity clinical laboratory testing. ** End of Report *.
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diff --git a/output/text/d55d9ed9-3663-4538-89e8-0d80e55cc678.txt b/output/text/d55d9ed9-3663-4538-89e8-0d80e55cc678.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1031096fd5ee74465335a1a928705359a9472113
--- /dev/null
+++ b/output/text/d55d9ed9-3663-4538-89e8-0d80e55cc678.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID: 5AEE90E0-A9A1-4944-AD6A-2675764D869D TCGA-AN-A0FV-01A-PRE Redacted TSS Patient ID. Case #: DOB: Sex: Female Ethnicity (Race):. Cancer Samplee Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma Date of Procurement:. Anatomic Site: Right Breast Tumor location: Primary. Tissue Specification: Tumor Specimen Matrix: Tissue Specimen Format: Frozen Container: cryomold Type of Procurement: Radical mastectomy Grade: 2 T Stage: 2 N Stage: 0 M Stage: 0 Treatment: none. Treatment Details: n/a. Norma! Sample Anatomic Site: Blood Sample Type: Norma! Type of Procurement: blood draw Matrix: Blood Specimen Format: frozen Container: tube. Date of Procurement:. Ics-0- 3 Larcinumn, infiAtnatng uluct,Nos 95oc/3 c50.9 Sife: brast Nus 10j2:j1 /0/2x/1t
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diff --git a/output/text/d564b817-5477-4013-93df-931e1e21622a.txt b/output/text/d564b817-5477-4013-93df-931e1e21622a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..dd4cc19838b795c0abdc950fb6d8d14f5a2f7433
--- /dev/null
+++ b/output/text/d564b817-5477-4013-93df-931e1e21622a.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:CC1EE9E0-BC1A-46ED-A262-7A2B9CC8BBB1 TCGA-HN-A2NL-01A-PR Redacted ple Type Tumour Primary bw 9Jtty Sample Preparation Fresh Frozen Site of Primary (Event) Site of Tissue Breast /cs-0-3 Year of Sample Collection Age at Sample Collection (yrs) Chrcinuma mfiltra#ng 1obuls, N0s 85wf7 56 Sample Comments Site: bresst, Nos c5o.9 Days to Procedure Date 0 Days to Diagnosis 7 9/(u/h Type of Procedure Surgical resection Site of Primary (Histology) Left breast Bilateral Disease Tumour Size (cm) 3.5 Histology Other Grade/Differentiation Grade IIl (high - poorly differentiated)  Pathological T T2 Pathological N  NO,NOS Number of Nodes Sampled 3 Number of Nodes Positive 0 Clinical M  MO Histology Comments  Inflitrating mammary carcinoma with lobular features No In Situ component. SBR (Scarff-Bloom-Richardson) score 9 ER Status  Negative PR Status Negative HER2 Status Negative Lymph Node Metastases None Documented
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diff --git a/output/text/d567a219-2f78-4e78-aaa7-9703e8abeafd.txt b/output/text/d567a219-2f78-4e78-aaa7-9703e8abeafd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7b911c2a8bc97ff549ebe4a1896d8efe60fefd00
--- /dev/null
+++ b/output/text/d567a219-2f78-4e78-aaa7-9703e8abeafd.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TCGA-AN-A03Y-01A-PR Redacted TSS Patient ID: Case #: DOB: Sex: Female Ethnicity (Race): Cancer Sample Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma Date of Procurement: -. Anatomic Site: Left Breast Tumor location: Primary Tissue Specification: Tumor Specimen Matrix: Tissue Specimen Format: Frozen Container: cryomold Type of Procurement: Radical mastectomy Grade: 2 T Stage: 2 N Stage: 0 M Stage: 0 Treatment: none Treatment Details: n/a.  Normal Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw Matrix: Blood Specimen Format: frozen Container: tube Date of Procurement: /c4-0-3 carcncn, nif1tnntivj duct,nvs 85vvf3 Site: brurf nvs. C50.1 iw lw 10jarJ!
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diff --git a/output/text/d5976b5a-7ecf-462f-a65f-bbee999b13cb.txt b/output/text/d5976b5a-7ecf-462f-a65f-bbee999b13cb.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a939c21c40314eede207840d996c7c701080d819
--- /dev/null
+++ b/output/text/d5976b5a-7ecf-462f-a65f-bbee999b13cb.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+ICD o 3 UUID:EE9D31A7-6B04-4C6F-94CD-10A1907D5B1D TCGA-VR-AA7D-01A-PR Redacted arcinenet Agulnseea.. 0 80>o13 thd 1  C15.4 Collect date: (MM/DD/YYYY) Qt>3)9[14 PATHOLOGY REPORT: PRIMARY SITE: Esophagus (Mid third) 1- Material designated as "cervical lymph node":. - Congested parathyroid showing volumetric increase. Note: depending on the correlation with clinical/radiological findings, the present case. may correspond to hyperplasia or parathyroid adenoma.. 2 - "Esophagectomy and partial gastrectomy":. - Moderately differentiated squamous cell carcinoma, measuring 7.5 cm, infiltrating the wall of the esophagus up to periesophageal adipose tissue;. - Angiolymphatic invasion present; - Perineural invasion present; - Scarce peritumoral desmoplasia; - Moderate lymphocytic peritumoral infiltrate;. - Surgical margins free of neoplasia; - Fragments of non-neoplastic esophageal mucosa showing congestion;. - Fragments of gastric mucosa with moderate chronic gastritis with atrophy and intestinal. metaplasia; - Metastasis to 7 of 13 dissected lymph nodes (11/13). 3 - "Margin of esophagus":. - Free of neoplasia. h 1s/20/13
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diff --git a/output/text/d5a8b939-010b-42bc-8803-bffbe040ba04.txt b/output/text/d5a8b939-010b-42bc-8803-bffbe040ba04.txt
new file mode 100644
index 0000000000000000000000000000000000000000..64dbabb9c2ed165d4ffa2fb746c6d1abfb2922c1
--- /dev/null
+++ b/output/text/d5a8b939-010b-42bc-8803-bffbe040ba04.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+Result Narrativ SURGICAL PATHOLOGY REPORT Pre-Operative/Clinical History. Right renal mass Specimen(s) Received A: RIGHT KIDNEY MASS Gross Description. The specimen is received fresh from the OR labeled right kidney mass:. Specimen type/procedure: Partial nephrectomy Laterality: Right. Description of specimen:. The specimen consists of a 25 gm, 5.0 x 4.0 x 3.0 cm partial nephrectomy. There is a thin Gerota' s fascia with multiple fibrous adhesions. The margins are inked as follows:. Margin of resection Black Gerota' s fascia Green. Adrenal gland:. Absent. Tumor site: Cortical. Tumor size: 4.0 x 3.5 x 3.5 cm. Tumor description: Well-circumscribed, bright yellow, focally. hemorrhagic solid mass..
+
+--- Page 2 ---
+Focality: Unifocal. Extent of invasion:. Tumor abuts Gerota' s fascia and the parenchymal margin of resection. Renal vessel involvement: Absent. Renal hilum: Uninvolved. Perinephric lymph nodes: Absent. Renal parenchymal lesions: None identified. Other: The mass encompasses approximately 90% of the. specimen. The uninvolved parenchyma shows the usual corticomedullary junction. Gross bench photographs are taken. Sections: (A1-A3) Mass and closest parenchymal margins of resection (A4, A5) Mass to include parenchymal margin and Gerota' s fascia. (A6) Mass and surrounding uninvolved parenchyma (A7) Uninvolved parenchyma. Microscopic Description Sections include kidney with a sharply circumscribed, partially encapsulated epithelial neoplasm. The neoplasm is characterized by a predominantly solid or. The predominant tumor cell is a small cuboidal cell with uniform, round, small bland nucleus and modest amounts of predominantly clear cytoplasm. There is a. second cell population present in the lumina of the tubules. The luminal population consists of larger polygonal cells with eosinophilic cytoplasm and a. single,  slightly enlarged oval to reniform nucleus with granular chromatin and a small nucleolus. The latter cells form intraluminal poorly cohesive sheets. There are scattered foci of foamy macrophages within the interstitium of the. tumor. Focally the tumor extends through its thin fibrous capsule and infiltrates into native renal parenchyma in a broad front. Focally tumor abuts. on an inked parenchymal resection margin (black ink, A2). In the histologic sections convincing extrarenal extension into perinephric soft tissue is not identified. A PAs stain is applied to sections of uninvolved nonneoplastic kidney (A7). It. demonstrates very focal mild interstitial fibrosis and tubular atrophy with rare colocalized ischemic sclerotic glomeruli. The glomeruli are unremarkable.. Neither crescents nor mesangial proliferation nor primary glomerulopathy is Seen. Summary of Pathologic Findings Renal Carcinoma Operative procedure: Laparoscopic robotically assisted right partial nephrectomy. Tumor size: 4.0 x 3.5 x 3.5 cm. Laterality and focality: Unilateral, right kidney
+
+--- Page 3 ---
+Histologic type: Papillary carcinoma, morphologic type I, predominant tubular growth pattern. Sarcomatoid features: Absent. Histologic grade: Furhman Grade 1-2. Extent of : invasion: No definite extrarenal extension identified. Tumor appears to be confined to kidney. Lymph/vascular invasion: Absent. Margins: Partial nephrectomy/enucleation: Renal capsule margin: Not involved. Perinephric fat margin: Not involved. Renal parenchyma margin: Focally involved. Adrenal gland: Not submitted. Regional lymph nodes: Not submitted.. Special studies: None. pTNM stage: pT1a pNX pMx(not applicable). Pathologic findings in nonneoplastic kidney: No significant pathologic findings identified. Focal minimal benign nephrosclerosis. Diagnosis RIGHT KIDNEY, RIGHT LAPAROSCOPIC PARTIAL NEPHRECTOMY: PAPILLARY CARCINOMA, LOW GRADE. NO EXTRARENAL TUMOR EXTENSION IDENTIFIED FOCAL INVOLVEMENT OF PARENCHYMAL MARGIN. CPT Code(s) A: 88329, 88307, 88313 Order Order Authorizing. Providers Unknown, Provider
+
+--- Page 4 ---
+Additional Associated Reports Information View Encounter Priority and Order Details Collection Information.
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diff --git a/output/text/d5ecadf4-524f-4695-8e98-a35912ac90ac.txt b/output/text/d5ecadf4-524f-4695-8e98-a35912ac90ac.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8491ace8d144651a0c3fd2a3bd3a00f0562c6d25
--- /dev/null
+++ b/output/text/d5ecadf4-524f-4695-8e98-a35912ac90ac.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+1co-o-3 Cmnimo, Httpntocillules, Nc5 (8170/3) xvl Operative Procedure: Laparoscopic right hepatectomy Site. lwu C32.0 Specimen Received: H31) Segment 8 hepatectomy Final Pathologic Diagnosis: Liver, segment 8, laparoscopic right hepatectomy: Hepatocellular carcinoma, with clear cell features, UUID:4ABC92B0-605C-462D-80DC-2A3CEE065C13 moderately-differentiated, see synoptic report. TCGA-G-A3OU-01A-PR Redacted Liver cancer synoptic report Specimen: Segment 8 of liver Procedure: Laparoscopic right hepatectomy Tumor histologic type: Hepatocellular carcinoma Tumor size: 2.7 cm (greatest dimension) Tumor focality: Unifocal Number of tumors: One Histologic type: Hepatocellular carcinoma with clear cell. features Histologic grade: Moderately-differentiated Tumor extension: Tumor confined to liver Margins: Parenchymal: Uninvolved Distance of invasive carcinoma from closest. margin: 1.6 cm Other margin: Not applicable Lymph-vascular invasion: Macroscopic venous (large vessel) invasion:  Not identified Microscopic (small vessel) invasion: Absent Pathologic staging: (pTMN) TNM descriptors: None known Primary tumor (pT): pT1 Regional lymph nodes (pN): pNX, lymph nodes not examined Distant metastasis (pM): Not applicable Additional pathologic findings: Cirrhosis; Steatosis The examination of this case material and the preparation of this report were performed by the staff pathologist. Gross Description: Received is a single formalin-filled container labeled with the patient's name and "segment 8 hepatectomy." The specimen consists of a portion of liver measuring 10.5 x 7.8 x 2.5 cm. The specimen is previously inked and dissected. The liver capsule is brown-tan smooth and lobulated. Further
+
+--- Page 2 ---
+sectioning reveals yellow-tan, firm, irregular ill defined mass measuring 2.7 x 2.3 x 1.8 cm. The mass abuts to the liver capsule and 1.6 cm from the nearest resection margin. The rest of the liver parenchyma is brown-tan and finely nodulated. Representative sections are submitted as follows:. 1-2  The mass to the inked surgical margin. 3-5  The mass to the liver capsule 6-7  The mass with adjacent liver parenchyma. 8-9 Uninvolved liver parenchyma Microscopic Description: The final diagnosis of each specimen incorporates the microscopic examination. findings. END OF REPORT Taken: DOB: (Age: . Gender:
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diff --git a/output/text/d6161e43-b36f-4418-bf8d-e691e9e38b5a.txt b/output/text/d6161e43-b36f-4418-bf8d-e691e9e38b5a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..faadda1c179021b1001d789cdae7d6600a190353
--- /dev/null
+++ b/output/text/d6161e43-b36f-4418-bf8d-e691e9e38b5a.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Icd-0-3 8 500|3 12810 Paith Ts! Sith: brost,ns. c50.9 CQcF UUID:514D4C2E-8215-4770-9FC1-25F988232A85 SPECIMENS: TcGA-E2-A15e-01A-pR Redacted A. SENTINEL LN #1 LEFT AXILLA B. LEFT BREAST MASS C. LEFT AXILLARY CONTENTS LEVELS 1,2 SPECIMEN(S): A. SENTINEL LN #1 LEFT AXILLA B. LEFT BREAST MASS C. LEFT AXILLARY CONTENTS LEVELS 1,2 GROSS DESCRIPTION: A. SENTINEL LN #1 LEFT AXILLA Received fresh is a tan pink firm grossly positive lymph node 1.3 x 0.8 x 0.5cm. Toto A1.. B. LEFT BREAST MASS Received fresh labeled with the patient's identification and "left breast needle localization" is an oriented 27g, 5.5 x 5. x 3cm needle localized lumpectomy with radiograph. Ink code: anterior-yellow, posterior-black, superior-blue, inferior- orange, medial-green, lateral-red. Specimen is serially sectioned from medial to lateral into 7 slices revealing a 2 x 1.5 x 1.5cm tan pink ill defined mass, closest to anterior margin at 0.4 cm in slices 2-6. A portion of the specimen is submitted for tissue procurement. Representatively submitted: B1: medial margin slice 1 B2: mass slice 2 B3-B5: slice 3 B6-B9: slice 4 B10-B12: slice 5 B13: mass slice 6 B14-B16: lateral margin slice 7 C. LEFT AXILLARY CONTENTS LEVELS 1, 2 Received fresh are multiple tan pink soft tissue fragments aggregating to 5 x 4 x 2cm. Dissection reveals 12 lymph nodes ranging from 0.1 x 0.1 x 0.1cm to 1.3 x 1 x 1cm. C1: 4 lymph nodes C2: 4 lymph nodes C3: 3 lymph nodes C4: 1 lymph node  C5-C11: axillary tissue DIAGNOSIS: A. SENTINEL LYMPH NODE 1, LEFT AXILLA, BIOPSY:E  - METASTATIC CARCINOMA (1.3 CM IN SIZE) TO ONE LYMPH NODE  WITH NO EXTRANODAL EXTENSION (1/1). B. BREAST, LEFT, NEEDLE LOCALIZATION WIDE LOCAL EXCISION: - INVASIVE DUCTAL CARCINOMA, SBR GRADE 3. - TUMOR MEASURES 1.1 CM - TUMOR IS 0.3 CM FROM THE ANTERIOR MARGIN. - DUCTAL CARCINOMA IN SITU (DCIS), SOLID TYPE, NUCLEAR GRADE 3, WITH NECROSIS, MINOR COMPONENT.E  - LOBULAR CARCINOMA IN SITU (LCIS), INVOLVING A RADIAL SCAR. - RADIAL SCAR WITH USUAL DUCTAL HYPERPLASIA AND MICROCALCIFICATIONS C. AXILLARY CONTENTS, LEFT, LEVELS 1 AND 2, DISSECTION: - EIGHT LYMPH NODES, NO TUMOR SEEN (0/8). SYNOPTIC REPORT - BREAST Specimen Type: Excision Needle Localization: Yes Laterality:  Left Invasive Tumor: Present Multifocality:  No WHO CLASSIFICATION Invasive ductal carcinoma, NOs 8500/3 Tumor size: 1.1cm
+
+--- Page 2 ---
+Tumor Site: 9:00 Margins: Negative Tubular Score: 3 Nuclear Grade: 3 Mitotic Score: 3 Modified Scarff Bloom Richardson Grade: 3 Necrosis: Absent Vascular/Lymphatic Invasion: Present Lobular neoplasia: LCIS Lymph nodes: Sentinel lymph node and axillary dissection Lymph node status: Positive 1/ 9 DCIS present  Margins uninvolved by DCIS DCIS Quantity: Estimate 2% DCIS Type: Solid DCIs Location:Associated with invasive tumor. Nuclear grade: High Necrosis: Present Location of CA++: Benign epithelium ER/PR/HER2 Results ER: Positive PR: Positive HER2: Positive by FISH Pathological staging (pTN): pT 1c N 1 SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimen:  Surgical Excision Block Number: A1 (lymph node with metastasis). ER: Positive Allred Score: 8 = Proportion Score 5 + Intensity Score 3 PR: Positive Allred Score: 8 = Proportion Score 5 + Intensity Score 3 COMMENT: The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 -  - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring range from O to 8. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2. METHODOLOGY:  Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours.  Immunohistochemistry was performed using the mouse anti-human ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) provided by following the manufacturer s instructions. This assay was not modified. Interpretation of the ER/PR immunohistocnemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal review of staining performance. CLINICAL HISTORY:  year-old female with invasive ductal carcinoma of left breast PRE-OPERATIVE DIAGNOSIS: Invasive ductal carcinoma INTRAOPERATIVE CONSULTATION: TPA: SLN #1- Positive for metastatic carcinoma. Diagnosis called to Dr. at 1 by Dr. Gross Dictation: 1  Microscopic/Diagnostic Dictation: Pathologist,. Final Review: Pathologist, Final: Pathologist,
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diff --git a/output/text/d61b20ff-3104-4a45-a697-baef1ab946c1.txt b/output/text/d61b20ff-3104-4a45-a697-baef1ab946c1.txt
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+Patient: Referring Physician: UUID:C2A0E948-289E-4E49-90C4-57CE4C4A95B30 TCGA-AC-A2QH-01A-PR Redacted DOB: Ref#: Patient Location: Date of Service: Date Received: Outpatient Case #: Room: Bed:  Date Reported: A copy of this report will be faxed to: FINAL SURGICAL PATHOLOGY REF- Diagnosis: A. LEft breast, TOTal mastectOmy (prOphylActIC): - Multiple intraductal papillomas with atypical ductal hyperplasia (ADH). - Radial scar, 8 mm in diameter. - Fibrosis, cysts, apocrine metaplasia, and sclerosing adenosis. - Skin with seborrheic keratosis. - No invasive carcinoma is identified. - Unremarkable intramammary Iymph node. S 1cs-0-3 8. & C) RIGHT BREAST AND AXILLARY LYMPH NODES, MODIFIED RADICAL MASTECTOMY: - Invasive high-grade sarcomatoid (metaplastic) carcinoma, with areas of matrix-producing carcinoma.. - Invasive tumor measures 95 mm in diameter.. - Lymphatic invasion is identified near the periphery of the tumor. - Resection margins are widely free of invasive carcinoma. 050.9 - Invasive carcinoma is present 40 mm from the closest margin (inferior) and is at least 50 mm from all other margins. - Twenty-two axillary lymph nodes, no tumor present. 8575/3 PATHOLOGIC TUMOR STAGING SYNOPSIS: Type and grade (invasive): High-grade sarcomatoid carcinoma, with areas of 3  matrix-producing carcinoma (subtypes of metaplastic carcinoma).. Primary tumor: pT3.. Regional lymph nodes: pNO.. Distant metastasis: pMX. Pathologic stage: liB.. Lymphovascular invasion: Identified near periphery of tumor. Margin status: Negative (R0). Case #: Page 1 Printed: This report continues... (FINAL) Phone:
+
+--- Page 2 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT COMMENT: The majority of the invasive carcinoma is characterized by solid sheets of high-grade malignant cells. In some areas, tumor cells have prominent spindle cell morphology, whereas in other areas, the malignant cells retain vaguely epithelioid (rounded) shapes, but have highly anaplastic nuclear features. Prominent tumor- associated necrosis is present, and no discernable glandular differentiation is evident. The morphologic appearance of these areas is compatible with designation as sarcomatoid (metaplastic) carcinoma. Other areas of tumor contain malignant cells present in close proximity to blue-gray chondromyxoid or hyaline matrix, compatible with at least focal matrix-producing carcinoma, another subtype of metaplastic breast carcinoma. Immunohistochemical staining shows some scattered tumor cells to be positive for p63 and CK5/6, in support of designation as metaplastic carcinoma. This Is in accordance with IHC staining performed on the previous biopsy In addition, some tumor cells are positive for smooth muscle actin, a feature not uncommon in metaplastic sarcomatoid carcinoma, representing immunohistochemical evidence of differentiatlon towards a myoepithelial phenotype. Staining for and S100 are negative in tumor cells. Focally, the invasive carcinoma is seen in association with a fibroepithelial neoplasm, a portion of which appears to be necrotic. The stroma of the fibroepithelial neoplasm does not show striking hypercellularity, except for a few areas in which there is granulation tissue. The lack of stromal cellularity within this lesion argues that the fibroepithelial neoplasm is best regarded as fibroadenoma, even though the lesion has some architectural features of phyllodes tumor. In some areas, high-grade malignant cells are seen to line the ducts/clefts of the fibroadenoma, suggesting that the carcinoma is invading into the fibroadenoma. Another possibility is that the carcinoma has arisen out of the epithelial component of the fibroadenoma, which is considered less likely. Sarcomatoid carcinomas are highly malignant tumors with capability to metastasize to distant sites (hematogenous metastasis to sites such as liver, lung, brain, etc.), even though some studies have shown that metastasis to axillary lymph nodes are significantly less frequent than in more typical cases of breast carcinoma (i.e. invasive Case #: Page 2 Printed: This report continues... (FINAL) Phone:
+
+--- Page 3 ---
+Patient: Case # FINAL SURGICAL PATHOLOGY REPORT ductal carcinoma, NOs). Dr. . Dr. have reviewed representative slides from this case, and concur with the diagnosis of metaplastic breast carcinoma. Case #: Pathology Consultation Report Page 3 Printed: This report continues... (FINAL) Phone:
+
+--- Page 4 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT Breast Invasive Tumor Staging Information (AJCC Cancer Staging Handbook, 7th Ed., and CAP protocol, Oct 2009). This staging also incorporates: Previous biopsy: Breast profile. Total breast, axillary lymph nodes, and Specimen type: contralateral breast. Modified radical mastectomy and contralatera! Specimen procedure: prophylactic mastectomy. Axillary dissection. Lymph node sampling: Single intact specimen. Specimen integrity: Right. Specimen laterality: 26 x 16 x 6.5 cm. Specimen size (other than mastectomy): INVASIVE TUMOR FEATURES: 95 mm. Invasive tumor size: Upper outer quadrant. Invasive tumor site: Single focus of invasive carcinoma.. Invasive tumor focality: Sarcomatoid (metaplastic) carcinoma, with areas Histologic type: of matrix producing carcinoma. 3 (high-grade). Total Nottingham Grade: 3 of 3. Tubule formation: 3 of 3. Nuclear Pleomorphism: 3 of 3. Mitotic count for Nottingham: Greater than 20 mitosis per 10 high power fields. Mitotic count: N/A. Other Grading System: Not identified. Lymphatic invasion: MARGIN STATUS FOR INVASIVE COMPONENT: 40 mm. Distance of tumor from margins: Closest margin: Inferior. Invasive and in situ carcinoma are present at Other margins: least 50 mm from all other margins.. DCIS not present IN-SITU CARCINOMA (DCIS) FEATURES:
+
+--- Page 5 ---
+FINAL SURGICAL PATHOLOGY REPORT LOBULAR CARCINOMA IN-SITU (LCIS): Absent. Skin: Unremarkabie. Nipple: Unremarkable.e Skeletai Muscle: Not present.e INVASIVE PATHOLOGIC TUMOR STAGING (pTNM) Primary tumor (pT): pT3. Regional lymph nodes (pN): pNO. Distant metastasis (pM): pMX. RECEPTOR STATUS AND HER2/NEU: ProPath, CM11-1333 Estrogen receptors:. Negative (0% positive cells). Progesterone receptors: Negative (0% positive cells). Her2/neu: Not overexpressed (IHC score 0). Ki-67 proliferative index: 50% positive cells. Signed by Source of Specimen: A. Left Breast total mastectomy B. Right Breast total mastectomy C. Additional Axillary Contents Clinical History/Operative Dx: Cancer, female breast, upper-outer Gross Description: A. The specimen is labeled left simple mastectomy and is received in formalin. It consists of a mastectomy specimen which weighs 1430 grams. A white suture at one end of the skin ellipse designates the lateral portion of the excision. With this orientation the specimen measures 26 cm from media! to Iateral, 17.5 cm from superior to inferior, and is up to 6 cm from superficial to deep. There is an overlying broad ellipse of tan-white skin which measures 26 x 15 cm. In the central slightly medial portion of the. skin there is a 4 cm areola with a protuberant 1.2 cm nipple. The medial-inferior skin displays a 0.7 cm plaque-like brown skin lesion. No other skin lesions are present. The anterior-superior margin is inked blue, the anterior-inferior margin is inked green, and the posterior margin, which consists of predominantly smooth fascial tissue, is inked black. The breast is serially sectioned at close intervals to reveal coarsely Iobulated fatty tissue and scattered tan-white fibrous parenchyma. The fibrous parenchyma contains. multiple punctate areas of fine nodularity throughout the breast with scattered blue-dome cysts. There are  no areas which have a stellate or retracted appearance. There are no lymph nodes identified in the Case #: Page 5 Printed: This report continues... (FINAL) Phone:
+
+--- Page 6 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT axillary portion of the tissue. Representative sections are submitted. Section summary: A1) nipple and tissue just deep to nipple, A2) inferior skin lesion, A3) representative breast tissue upper-inner quadrant,. A4) representative breast tissue lower-inner quadrant, A5) representative breast tissue upper-outer quadrant, A6) representative breast tissue lower-outer quadrant, A7) representative tissue central breast including representative deep margin. '. Following review of the initial slides, additional representative sections from the central portion of the breast tissue are submitted from medial to lateral in cassettes A8-A12. A lymph node and random sections of breast tissue are submitted in cassette A13.. B. The specimen is labeled right modified radical mastectomy and is received without fixative. It consists of a mastectomy specimen which weighs 1681 grams. A suture marks the axillary tissue. With this orientation the breast measures 26 cm from medial to lateral, 16 cm from superior to inferior, and 6.5 cm from superficial to deep. The axillary portion measures 9 x 7 x 3 cm. The breast has an overlying broad ellipse of tan skin measuring 25 x 16 cm. There is a medial and slightly inferiorly located poorly delineated 4 cm areola with a protuberant 1.2 cm nipple. The central skin surface bulges outward in the periareolar area over a distance approximately 8 cm. The skin is otherwise tan-white and unremarkable. Sections of the bulging anterior skin reveal a partially hemorrhagic cavitary lesion which measures 7 cm from medial to laterai, 7 cm from superior to inferior, and up to 3.5 cm from superficial to deep. The cavitary space is filled with gray-tan tissue which has a finely lobulated appearance. Just inferior to the cavitary space along the lateral edge there is creamy tan-white moderately firm fibrous breast parenchyma. Representative tissue obtained for research purposes. Following fixation the anterior- superior margin is inked blue, the anterior-inferior margin is inked green, and the posterior margin, which consists predominantly of smooth fascial tissue, is inked black. The breast is serially sectioned from the posterior surface at close intervals to reveal the cavitary lesion described above. The breast parenchyma is otherwise tan-white and has fine palpable nodularity most notable in the lower-inner quadrant. The creamy tan-white tissue at the posterior edge of the hemorrhagic lesion is 5 cm from the closest superior margin, 4 cm from the closest inferior margin, 5.5 cm from the closest deep margin, 7.5 cm from the. closest medial margin, and 13 cm from the closest lateral margin. At its greatest dimension which is superior-inferior the creamy white tissue at the posterior edge of the cavitary lesion measures 6.5 cm.. Representative sections are submitted. Section summary: B1) nipple and tissue just deep to nipple, 82) representative skin with closest approach of hemorrhagic cavitary lesion,. B3) medial edge of hemorrhagic lesion, B4-B5) sections cavitary lesion progressing centrally,. 86-B8) central-posterior portion of cavitary lesion with firm white tissue, B9-B10) representative sections from lateral portion of hemorrhagic lesion, B11) possible intramammary node 2.5 cm lateral to hemorrhagic lesion, B12) representative breast tissue upper-inner quadrant (medial to hemorrhagic lesion),. B13) representative tissue lower-inner quadrant of breast (medial to hemorrhagic lesion), Page 6 Pathology Consultatlon Report Case #: This report continues... (FiNAL) Printed: Phone:
+
+--- Page 7 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT B14) representative breast tissue upper-outer quadrant (lateral to hemorrhagic iesion), B15) representative breast tissue lower-outer quadrant (lateral to hemorrhagic lesion), B16) deep surgical margin closest to posterior edge of cavitary lesion,. 817-B19) nodal tissue trimmed from largest predominantly fatty (3.9 cm) node, B20-B21) second largest node serially sectioned, B22) single node seriaily sectioned,. B23) two nodes bivalved (one inked), B24) two node, one inked and trisected, one trisected, B25) four possible nodes intact, 826) two nodes bivalved (one inked), B27) smaller possible nodes intact.. Following review of the initiaily submitted sections, additional sections of the tumor are submitted as follows: B28-B32) polypoid necrotic appearing portion of tumor,. B33) breast tissue surrounding tumor, B34-B35) representative sections of solid tan portion of tumor. ( C. The specimen is labeled additional axillary contents right axilla and is received in formalin. It consists of a 1.8 cm fragment of fibrofatty tissue. On dissection there are two intact nodes, the larger node measuring 1.5 x 1.1 x 0.6 cm and the smaller node 0.6 cm in maximum dimension. The larger node is sectioned and submitted in cassette C1. The smaller node is bivalved and submitted in cassette C2. (DS) Microscopic Description: A. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered. B. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered. IHC stains: p63, CK5/6, SMA, S100. See comment for staining results. Appropriate positive and negative controls reviewed. C. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered. Case #:  Pathology Consultatlon Report Page 7 Printed: REPRINT: Orig. printing on Phone
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+Patient Name: Accession #: Med. Rec. #: Date ot Procedure DOB: Date of Receipt: Gender: Date of Report: Rot. Physician: Account # Pattlent Address: Blling Type: Additional Copy to: Ret. Source: Clinical Diagnosis & History: Palient with history of lefl LE sarcoma and incidental right renal mass. Specimens Submitted: 1: Kidney, right core biopsy 2: Kidney, right; radical nephrectomy  3: Lymph nodes, pre and paracaval: excision DIAGNOSIS: Kidney, right; core biopsy: Renal cortical neoplasm. Kidney, right; radical nephrectomy Tumor Type High grade renal cell carcinoma with exlonsive papillary. cribriform, and solid features, most compatible with a tumor of distal nephron/collecting duct origin; see note Tumor Sizo: Greatest diameter is 3.6 cm. Local Invasion (lor renal cortical types):  Involves renal sinus fat Renal Vein Invasion  Tumor invades medium to large size muscular vessels as well as lymphatic spaces in the region of the renal sinmus Surgical Margins: Free of tumor Non-Neoplastic Kidney: Mild interstiial chronic inflammation Adrenal Gland: Not identified Lymph Nodes: Not identified Staging for renal cell carcinoma/oncocyloma: pT3b Tunor grossly extends into the renal vein(s) or vena cava bolow tho diaphragm Note: The tumor exhibits multinodular growth, desmoplasia, and necrosis. Immunohistochemical stains are positive for CK7 (focal strong). Racemase (diffuse, strong). and 34BE12 (focal. weak), while negative for CK20 and CA-9. Allhough this tumor does Page t of 4
+
+--- Page 2 ---
+exhibit an extensive papillary growth paltern. ils range of features a.n. noprofile are most compatible with a dista!  nephron/collecting duct tumor. This case was reviewed with the. Consensus Conference which concurs with the. diagnosis. 3. Lymph nodes, pre and paracaval; excision: Lymph Nodes:. Not involved Number of nodes examined:11 TATTE ST THAT THE ABOVE DIAGNOSIS I$ BASED UPON MY PERSONAL EXAMINATION OF THE SLIDE S AND/OR OTHER MATERIAL), AND THAT HHAVE REVIEWED AND APPROVED THIS REPORT Special Studies:. Rosull Special Stain Comment RECUT RECUT RECUT RECUT RECUT RECUT CK7 RACEMASE 348E12 CK20 CA-1X. NEG CONT IMM RECUT CD117 RECUT RECUT RECUT RECUT Gross Description: 1). The specimen is received fresh for frozen section consultation, labeted "Right renal mass biopsy" and consists of a piece ol soft. tissue measuring 1.0 x 0.2 x 0.1 cm. Entirely submitted for frozen secllon.. Summary ol sections: F$C - frozen section control 2). The specimen is received fresh for frozen section consullation. labeled "right kidney" and consists of a kidney with atlached uretor, renal vessels and perinephric fal weighing 180 g in lotal.. The kidney moasures 11 x 7.5 x 3 cm.The attached ureler. measures 2.7 cm in length and 0.4 cm in diameter. The allached renal vein measures 1 cm in length and 0.8 cm in diameter. The. renal vessels and ureter margins aro grossly unremarkable. An adrenal gland is not identified The kidney is inked black and.  bivalved to reveal a heterogeneous tan pink to golden yetlow infiltrating tumor that is focally very friable that measures 3.6 x 3.4 x 2.5 cm tocatod in the corlex with focal extension to the perirenal fat and atso exlonsion to the medulla and focally to the renal sinus fat. The tumor is not involving the renal polvic or renal hilar fat. Sections through the romainder of tho kidnoy revoal pink brown parenchyma wih a well-delined cortico-medullary junction. The cortex measures 0.7 cm and the calyces appear normal No Page 2 of 4
+
+--- Page 3 ---
+Iymph nodes are identified in the perinephric fat. The specimen is pholographed. Representative sections are submilted for TPS. and for permanent sections. Summary of seclions: UVM -- ureteral and vesset margins T .- tunor HF -- tunor with hilar fat TSF -- tumor with sinus fat TK -- tumor with adjacent kidney RP -- renal pelvis representative sections K -- representative sections kidnoy TCF .- lumor to capsule and perirenal fal FCS -- frozen control section 3). The specimen is received in formalin, labeled "Pre and para cava lymph nodes" and consists of six pink tan firm lymph nodes ranging irom 0.4 to 2.7 cm in greatest dimension. All identified lymph nodes are submitted. Summary of sections: LN -- lymph nodes BLN-- bisected lymph node Summary of Sections: Part 1: Kidney, right; core blopsy Block Sect. Site PCs FSC 1 1 Part 2: Kidney, right: radical nephrectomy Block Sect. Site PCs 1 FCS 1 1 HF 1 1 K 1 1 RP 1 2 2 2 TCF 2 2 TK 2 2 TSF 2 UVM 1  Part 3: Lymph nodes, pre and paracaval; excision Block Sect. Site PCs 2 BLN 2 2 LN 5 Intraoperative Consultation: Note:  The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative. consultation. FROZEN SECTION DIAGNOSIS: SPRIGHT RENAL MASS BIOPS EPITHELIAL NEOPLASM DEFER. PERMANENT DIAGNOSIS:SAME 2 FROZEN SECTION DIAGNOSIS: SP: RIGHT KIDNEY RENALCORTICAL.CARCINOMA.WITH PROMINENT PAPILLARY ARCHITECTURE PERMANENT DIAGNOSIS: SAME Page 3 of 4
+
+--- Page 4 ---
+Page 4 of 4 END OF REPORT
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index 0000000000000000000000000000000000000000..512319d95746c16f8428fe428479d5cf1e399733
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+
+--- Page 1 ---
+PAGE 1 RUN DATE: RUN TIME: User: RUN USER:! ACCr #: PATIENT ROOM: REG AGE/SX : BED: DIS: DOB: REG DR: STATUS: STATUS: SPEC # RECD: TIME IN FORMALIN: 6:26 hrs. COLL : COLD ISCHEMA TIME: 0:00 mins. CLINICAL INFORMATION: Pre-Op Diagnosis: Colon cancer Remarks: tcd-o-3 Specimen(s) : A. Omental implant B. Left colon C. METS 84$s/3 Site : Qeesendlirey eolons J e 13ll3 MICROSCOPIC DIAGNOSIS OMENTAL IMPLANT) RESECTION: METASTATIC MUCINOUS ADENOCARCINOMA CONSISTENT WITH COLON PRIMARY B LEFT COLON, LEFT HEMICOLECTOMY: MUCINOUS ADENOCARCINOMA OF THE DESCENDING COLON POSSIBLY ARISING IN TUBULOVILLOUS ADENOMA CARCINOMA INVADES THROUGH COLON WALL INTO SUBSEROSAL ADIPOSE TISSUE AND EXTENDS TO WITHIN 1 MM OF PERITONEAL SURFACE AND RADIAL MARGIN TUMOR ADHERENT TO ABIOMINAL WALL BY CLINICAL HISTORY SURGICAL MARGINS OF RESECTION FREE OF TUMOR WITH CLOSEST MARGIN RADIAL MARGIN 1 MM METASTATIC MUCINOUS ADENOCARCINOMA, IN THREE (3) OF NINETEEN (19) SUBSEROSAL LYMPH NODES LYMPH-VASCULAR INVASION NOT IDENTIFIED SEE COMMENT FOR SURGICAL PATHOLOGY CANCER CASE SUMMARY CHECKLIST C. PERITONEAL METASTASES. RESECTION:  MUCINOUS ADENOCARCINOMA CONSISTENT WITH METASTATIC COLON CARCINOMA COMMENT(S)  Results will the specimen will be forwarded for KRas analysis.. At request of be reported as an addendum when complete. SURGICAL PATHOLCGY CANCER CASE SUMMARY - APPROVED BY COLLEGE OF AMERICAN PATHOLOGISTS UUID:1D9DC00B-044F-4304-8C27-077BB64A5C48 Descending colon SPECIMEN: TCGA-NH-A6GC-06A-PR Redacted Left hemicolectomy PROCEDURE : Left (descending) colon TUMOR SITE: ** CONTINUED ON NEXT PAGE *
+
+--- Page 2 ---
+RUN DATE: RUN TIMI PAGE 2 RUN USER: User: SPEC #: PATIENT: (Continued) Comment(S) (Continued) TUMOR SIZE: 8.0 cm MACROSCOPIC TUMOR PERFORATION: Not identified HISTOLOGIC TYPE: Mucinous adenocarcinoma HISTOLOGIC GRADE: Low--grade  MICROSCOPIC TUMOR EXTENSION: Tumor is adherent to other organs or structures. abdominal wall MARGINS : If all margins uninvolved by invasive carcinoma. distance of invasive carcinoma from closest margin: 1 mm. radial Proximal margin: uninvolved by invasive carcinoma Distal margin: uninvolved by invasive carcinoma Circumterential margin: uninvolved by invasive carcinoma TREATMENT F *FECT: No prior treatment LyMPH-VA  AR INVASION: Not identifiod  NVASION : Not identified TUMOR ..:QSITS: Not identified TYPE OF FOLYP IN WHICH INVASIVE CARCINOMA AROSE: Tubulovillous adenoma - possible PATHOLCGIC STAGING: Primary tumor: pT4b Regional lymph nodes:. pN1b Number ot lymph nodes axamined: 19 Number of lymph nodes involved: 3 Distant metastasis:.  pM1b. omentum and peritoneum ANCILLARY STUDIES: KRAs mutational analysis pending GROSS DESCRIPTION: The specimen is received in three parts. Each part is labeled with the patient's name. A. Labeled "omental implant" is received fresh for frozen section diagnosis and is a 9.0 x 6.0 x 2.5 cm diffusely indurated. nodular portion of yellow. lobulated omental adipose. The adipose has multiple. mucinous tumor massos with two large masses ranging up to 6.0 x 4.5 x 2.5 cm. The section is sampled for frozen section diagnosis. The tissue is sampled to have solid to minutely cystic. mucin-filled masses throughout the specimen. A section is sampled for frozen section diagnosis. An additional section is sampled for tissue banking. Additional representative sections are sampled from across the specimen: A1 frozen section residue. A2-A4 additional sections sampled B. Labeled "left colon" and received fresh for tissue banking is a 23 cm segment of large bowel. The bowel has a distal area of indurated. creeping fat. This region is inked bluo on the serosa. The bowel is opened to have an 8.0 x 7.0 x 3.0 cm mucinous tumor mass. The mass comes to within 4.5 cm of the distal margin. l4 cm from proximal. The tumor diftusely involves and axtends through the bowel wall and extends close to the inked serosa and mesenteric. radial fat margin. There is l.5 cm of adipose between the bowel wall and radial ! fat margin. The tumor extends nearly to this inked margin. Surrounding mucosa is otherwise unremarkable with normal. tan folds. The adipose is sectioned to have multiple nodular lymph nodes. The lymph nodes are focally tumor replaced with a mucinous appearing cut ** CONTINUED ON NEXT PAGE **
+
+--- Page 3 ---
+RUN DATE RUN TIME! PAGE 3 RUN USER: User SPEC # PATIENT: Continued) GROSS DESCRIPTION: (Continued) surface. Sections of the tumor are sampled for tissue banking. Representative sections are sampled for routine histology as labeled: B1 proximal margin B2 distal margin B3-B7 sections of tumor extending through bowel wall into underlying adipose to the inked serosal and radial fat margin B8-B11 whole lymph nodes from proximal to distal B12 tumor replaced lymph node sampled C. Labeled "mets" and received in formalin is a 5.0 x 3.0 x 2.0 cm portion of yellow adipose. The adipose has two mucinous tumor nodules at either pole. The smaller nodule is 1.0 cm and ths larger nodule is 2.3 x 2.3 x 1.7 cm. Representative sections are sampled to. include normal. adjacent omental adipose cassettes C1-c2. MICROSCOPIC DESCRIPTION : The slides are examined and evaluated. INTRAOPERATIVE CONSULTATION: FROZEN SECTION DIAGNOSIS. OMENTAL IMPLANT: METASTATIC ADENOCARCINOMA PHOTO DOCUMENTATION Image Image Image Image Image Signed (signature on file). ** END OF REPORT
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+
+--- Page 1 ---
+PaTient history: The patient a PRE OP DiAGNOSIS: Colon cancer. POST OP DIAGNOSIS: Same PROCEDURE: Slamoid colectomy. FINAL DIAGNOSIS: Part 1: colon, SigmoiD, partial colectomy - Collection Date:  MOdEraTeLy DIFfEreNTIated ADenOcarcInOmA, 6.0 Cm. B. TUmoR inVADEs THrOUgh mUScULARIS PROpRIA. C. TumoR ARISEs iN The BAcKgRoUND Of A TuBULOVILLouS ADenOmA. D. MARGINS OF RESECTION ARe fREE Of TumOR. E.  NO evIdence Of anGiolymphatic InvasiOn Are iDentIfieD. ELEVEN(11) LYMPH NODES ARE NEGATIVE FOR METASTATIC TUMOR. G. TNM PATMOLOGIC STAGE - pT3, N0, MX H. TNm hIStopatHolOgic GraDE - G2. DUKES' STAGE: B, ASTLER-COLLER STaGE: 82.  SEPAraTe SmaLL. TUbULAR aDeNOmA, 0.2 CM. Part 2: Lymph node. pelvic, excision -- ONe(1) Lymph nODE nEgaTIVe For metastaTIC DiSEASE. SYNOPTIC - PRIMARY COLON AND RECTAL TUMORS A Location: s 1.  Heocecal Region 4. Descending Colon 2. Ascending Colon 5. Sigmoid Colon 3.  Transverse Colon 6. Rectum B Procedure: 1 1  Segmental Colectomy 3. Other 2. Total Colectomy  Size of Tumor (maximum dimension): 5.0 cm D Type: 1 Adenocarcinoma, NO$ 9. Squarmous Cell Carcinoma 1 2.  Adenocarcinoma arising in a background 10. Undifferentiated Carcinoma of an adenoma. 11. Sarcoma 3  Adenocarcinoma arising in a background 12. Smooth Muscle Tumor of inflammatory bowel disease 13. Gastrointestinal stromal tumor 4. Adenosquamous carcinoma 14. Lymphoma 5. Carcinoid Tumor (Neuroendocrine Tumor) 15 Other 6.  Mucinous Adenocarcinoma 7.  Signet ring cell type Adenocarcinoma 8.  Neuroendocrine Carcinoma E Grade: 2 1. Well differentiated 2. Moderately differentiated 3. Poorly differentiated F. Extent of Infiltration: 4 1.  Limited to the mucosa 4. Infiltrating through rmuscularis propria into serosal 2.  Into submucosa adipose tissue  Involving muscularis propria 5. Involving adjacent organs/ peivic wall G. Angiolymphatic Invasion:  2 Yes 2.No M Surgical Margins Involved: 2 Yes 2.No Regional Lymph Node Involvenent:2 1. Yes 2.No If regional tymph nodes involved. Number positive/number examined: N/A/#. K. Extracapsular spread : N/A Yes 2.No. Associated conditions: 3/#/#/# L Ulcerative colitis. 2. Crohn's Disease. 3. History/ presence of adenomatous polyps. Multiple polyposis syndromes.. 5. Diverticulosis M. TNM Stage: T3 NQm X N. Dukes' Stage: 2 A (limited to mucosa and muscularis) 2.  B (through muscularis into subserosa) 3 C (through subserosa and involving adjacent organ/pelvic wall/regional or distant ymph nodes) O. Astler - Coller $tage: 3 A (mucosa but not into muscularis propria} 2. B1 (muscularis propria but not through, LN negative) : 3.  B2 (through muscularis propria into subserosal fibroadipose tissue, LN negative) 4. C1 (himited to muscularis propria but not through serosa, LN positive) 5. C2 (invades serosal adipose tissue, LN positive)
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diff --git a/output/text/d686d7b8-216f-4ac4-a526-d2ab93c11b46.txt b/output/text/d686d7b8-216f-4ac4-a526-d2ab93c11b46.txt
new file mode 100644
index 0000000000000000000000000000000000000000..89feee69a91a7b786fba37834dbc5e04f1396119
--- /dev/null
+++ b/output/text/d686d7b8-216f-4ac4-a526-d2ab93c11b46.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+tcD 0-_3 TCGA-G2-AA3F-01A-PR Redacted CareLrsnay,WritheQisI NOS 8/20/3 DIAGNOSIS (A) BLADDER TUMOR: UROTHELIAL CARCINOMA, HIGH GRADE (GRADE 3) WITH MICROPAPILLARY FEATURES (15%), INVASIVE INTO MUSCULARIS PROPRIA.. LYMPHOVASCULAR INVASION PRESENT. Prostatic tissue with stromal nodular hyperplasia, negative for adenocarcinoma. GROSS DESCRIPTION (A) BLADDER TUMOR - Multiple light gray and dark brown unoriented fragments of soft tissue (8.0 x 7.5 x 4.5 cm in aggregate). SECTION CODE: A1-A10, representative fragments are submitted. CLINICAL HISTORY Bladder cancer. CLINICAL HISTORY Bladder cancer. 10/31/13
\ No newline at end of file
diff --git a/output/text/d6c4ffc0-c366-4c2a-8e61-c90e3be0754a.txt b/output/text/d6c4ffc0-c366-4c2a-8e61-c90e3be0754a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d0d2d79e693696ac41184c4c66b4b71a5e2586cd
--- /dev/null
+++ b/output/text/d6c4ffc0-c366-4c2a-8e61-c90e3be0754a.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID: 16BE8338-E17B-4B8A-9D71-B0D83D73D9DE Redacted Final Diagnosis Yeast, Ieft, wide local excision and simple mastectomy: Infiltrating ductal carcinoma, Nottingham grade III (of III), [tubules 3/3, nuclei 2/3, mitoses 3/3; Nottingham score 8/9], forming a 2.4 x 2.0 x 1.6 cm mass (in the wide local excision specimen) [AJCCpT2]. Extensive ductal carcinoma in-situ, high nuclear grade, present within (> 25%) and outside the invasive component involving an area measuring at least 3.8 x 2.2 x 2.0 cm.  Angiolymphatic invasion is absent. The non-neoplastic breast parenchyma shows proliferative fibrocytic changes and multiple small intraductal papillomas. Biopsy site changes present. Multiple margins on the wide local excision specimen, including the separately submitted inferior margin, are positive for tumor. There is residual in-situ carcinoma in the mastectomy specimen adjacent to the biopsy cavity which is located in the outer quadrant. The tumor does not involve the nipple, overlying skin, or underlying chest wall. All surgical margins, mastectomy, are negative for tumor (minimum tumor free margin, 1.7 cm, deep margin). Lymph nodes, left axillary sentinel, excision: Multiple (3) left axillary sentinel lymph nodes are negative for metastatic carcinoma [AJCC pN0 (i-) (sn)]. Blue dye is identified in left axillary sentinel lymph nodes No. 1 and No. 2. Blue dye is not identified in left axillary sentinel lymph node No. 3. Lymph node, left axillary non-sentinel, excision: A single left axillary non-sentinel lymph node (adjacent to left axillary sentinel lymph node No. 1) is negative for metastatic carcinoma. Estrogen and progesterone receptor analysis and Her-2/NEU have been ordered on paraffin-embedded tissue. /cs-0-3 carcnona, iifiltratirg cluct, ns 8500/3 Sij: bresst, Nos c50.9
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diff --git a/output/text/d6f4cdd7-553f-4cbe-88dd-0eb5fb81b1b4.txt b/output/text/d6f4cdd7-553f-4cbe-88dd-0eb5fb81b1b4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c34178378dc356c2328b7bc5479c3d5edc83d5d3
--- /dev/null
+++ b/output/text/d6f4cdd7-553f-4cbe-88dd-0eb5fb81b1b4.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+CGA-AY-4070 SURGICAL PATHOLOGY REVISED REPORT Surgical Pathology Report * Amended * A: Implant, uterine, biopsy. - Nodule of benign smooth muscle consistent with leiomyoma, no tumor seen.. B: Colon, right, hemicolectomy. Tumor Histologic Type: adenocarcinoma. Histologic Grade: poorly differentiated. Depth of Invasion: through muscularis propria into. pericolic adipose tissue. Lymphatic (Small Vessel) Invasion: present. Venous (Large Vessel) Invasion: present Perineural space invasion: present. Margins: Proximal margin: free of tumor. Distal margin: free of tumor.
+
+--- Page 2 ---
+Circumferential (radial) margin: involved with tumor (block B11) Regional lymph nodes:. Total number with metastasis: 5. Total number examined: 15 AJCC PATHOLOGIC TNM STAGE: at least pT3, cannot exclude pT4 pN2 pMx Note: This pathologic stage assessment is based on. information available at the. time of this report, and is subject to change pending. clinical review and. additional information. Additional pathologic findings: The appendix shows fibrous obliteration. The attached portion of small bowel shows no pathologic. abnormality. Intraoperative Consult Diagnosis: A frozen section was requested by FSAl: "Uterine implant", biopsy - Benign fibromuscular tissue, no carcinoma seen.. Clinical History: a clinical diagnosis of colon cancer, now undergoes right hemicolectomy. Gross Description:. Received are two appropriately labeled containers.. Container A is additionally labeled "uterine implant." It contains a 0.4 x 0.3 x 0.3 cm white and red soft tissue fragment; block FsAl, NTR. Container B is additionally labeled "right colon.". Specimen fixation: formalin.
+
+--- Page 3 ---
+Parts of bowel received: terminal ileum, cecum, proximal. ascending colon, appendix Specimen length: terminal ileum, 11 cm; cecum/colon, 36 cm; appendix, 7 cm Orientation: By anatomic landmarks. Inking: radial margin/blue. Tumor location: cecum. Gross appearance of tumor: The tumor on the mucosal surface is present as an indurated depression with a rolled border. Cross sectioning reveals additional rubbery firm white solid tissue with focal yellow necrosis. This is present in the pericecal adipose tissue/subserosa. The tumor mass here has an infiltrative border with a stellate pattern of extension, including to the radial margin. Tumor dimensions: 6.5 x 3.0 x 3.0 cm Circumferential growth: 40% Gross depth of invasion: Tumor invades through the muscularis propria into the. subserosa/pericecal adipose tissue. Gross evidence of perforation through visceral peritoneum: Tumor is at least very close to the peritoneum. Luminal obstruction: not appreciable Bowel circumference at tumor site: 7 cm Gross distance of tumor from margins: 11 cm to terminal ileum margin, 32 cm to colon margin, radial margin is at least within 1 mm, may be positive. Lymph nodes: per block summary Other remarkable findings: Within the subserosa directly. below the primary tumor. mass, there are multiple foci of yellow/white tumor nodules distending circumferential fibrous tissue..
+
+--- Page 4 ---
+These may represent lymph nodes completely replaced by tumor,. vascular invasion, and/or exuberant desmoplastic response to subserosal tumor deposits. Tissue submitted for special investigation: Tumor and normal tissue to Tissue procurement. Digital photograph taken:. Block Summary: Inking: radial margin is blue. B1,B2 - terminal ileum margin of resection, en face B3-B5 - colonic margin of resection, en face B6-B8 - full thickness cross section of tumor, from mucosa to positive radial margin B9-Bl1 - full thickness cross section of tumor, from mucosa. to positive radial margin B12 - additional view of subserosal invasion. B13-B15 - additional views of grossly positive radial. margin B16,Bl7 - subserosal tumor deposits with circumferential fibrous tissue B18,B19 - tumor, transition to normal mucosa. B20 - normal colon, distal from tumor B21 - normal terminal ileum, distal from tumor B22 - appendix, cross section of tip and en face sections of base and middle. B23 - two lymph node candidates, one bisected and inked blue B24 - tumor replaced lymph node versus vascular invasion B25 - two lymph node candidates, larger bisected and inked. blue B26 - two lymph node candidates B27 - three lymph node candidates. B28 - two lymph node candidates. B29 - three very small lymph node candidates B30 - two lymph node candidates. B31-B40 - perivascular adipose tissue
+
+--- Page 5 ---
+Grossing Pathologist: Light Microscopy:.
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diff --git a/output/text/d6f65bbb-489a-4994-8051-62cf74b18006.txt b/output/text/d6f65bbb-489a-4994-8051-62cf74b18006.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d96a253ded4947cb0b1071b48f82203f63bbb7ff
--- /dev/null
+++ b/output/text/d6f65bbb-489a-4994-8051-62cf74b18006.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+C artionp , infgiltnatiag plu.ct.lyos 8560/3 UUID:F93E326D-F4E0-4000-8A67-AA19C4D3637A d50.1 TCGA-A2-A1FZ-01A-PR 1/25/4 Redacted CQcF- Sif: brut,nos c50.9 W Chi.t of Phone Yax Specimen: Received: Status: Spec Type: SURGICAL p Subm Dx: RT BR CA - INVASIVE DATE: DOCTOR(s) : PRocEDurK : A.RT BR TISSUE B.RT AX SENTINEL NODE #1 C.RT AX SKNTINEL NODE #2 D.RT AX SENTINEL NODE #3 PART A RECEIVED LABELED RIGHT BREAST, IS A SIMPLE MASTECTOMY SPECIMEN MEASURING 28 X 27 X 5.7~CM. THE NIPPLE IS UNREMARKABLE. THE SURROUNDING SKIN ELLIPSE MEASURES 25.5 X 16.3 CM. FOCAL BLUE DYE IS NOTRD IN THE CENTRAL PORTION OF THE SKIN WHICH IS UPPER OUTER QUADRANT TO THE NIPPLE. A SUTURE DENOTES 12 O'CLOCK. ADDITIONALLYS WITHIN THK CONTAINER IS A V-SHAPED PORTION OF SKIN WITH UNDERLYING FATTY TISSUE MEASURING 9.5 X 10 X 1.6 CM IN GREATEST DIMENSIONS. OTHERWISE ORIENTED. THIS IS NOT THE SUPERFICIAL ASPECT IS MARKED WITH BLUE INK, THE DEEP WITH BLACK INK.  SECTIONING REVEALS BLAND YELLOW FATTY TISSUE WITH FINE FIBROUS BANDS AND A STELLATE PINK-GRAY FIBROUS LESION IN THE 9 O'CLOCK AREA MEASURING 2.2 X 1.7 X 3.0 CM FROM MEDIAL TO LATERAL. IS ALSO IN THE CENTRAL PORTION OF THE BREAST. IT IS 2 CM FROM THE DEEP  THIS MARGIN AND 2 CM FROM THE SKIN AND THEREBY GRKATER THAN 3 CM FROM ALL OTHER MARGINS.  SECTIONS ARE SUBMITTED AS FOLLOWS: A1--NIPPLE (MIRROR IMAGE TO PROTOCOL). A2--DEEP MARGIN TO LESION, A3 AND 4--FULL CROSS-SECTION OF LESION, A5--LESION, A6 AND 7--FULL CROSS-SECTION OFS LESION. NOTE THAT AS THROUGH A7 ARE MIRROR IMAGE TO PROTOCOL SECTIONS AND NOTE THAT A7 IS IN AREA OF WING CLIP. A8--UPPER INNER QUADRANT,S A9--UPPER OUTER QUADRANT, A1O--LOWER OUTER QUADRANT, A11--LOWER INNER QUADRANT. NOTE: AS THROUGH A11 ARE MIRROR IMAGES TO PROTOCOL SECTIONS. SECTIONING THE SEPARATELY SUBMITTED PORTION OF TISSUE REVEALS IT TO BE GROSSLY UNREMARKABLE, AND A REPRESENTATIVE SECTION AT THE POINT OF THE V IS SUBMITTED LABELED A12. PART B  RECEIVED LABELED RIGHT AXILLA SENTINEL NODE #1, IS A 3 X 1.8 X 1.2 CM PORTION OF YELLOW FATTY TISSUE WITHIN WHICH IS A 1.5 CM CENTRALLY FAT-REPLACED GROSSLY UNREMARKABLE LYMPH NODE.  THIS IS BISECTED AND SUBMITTED LABELKD B. PART C RECEIVED LABELED RIGHT AXILLA SENTINEL NODE #2, IS A 3.7 X 2 X 1.3 CM IRREGULAR FRAGMENT OF YELLON-RBD FATTY TISSUE. SECTIONING REVEALS A GROSSLY FAT-REPLACED GROSSLY UNREMARKABLE LYMPH
+
+--- Page 2 ---
+Chist of Fathology Phone Tax Speciment Received: Status: Req Sp@C TYPe: SURGICAL P Subm Dx s (Continued) NODE,  SUBMITTED LABRLED C1 THROUGH 3. PART D RECEIVED LABKLED RIGHT AXILLA SKNTINEL NODE #3, IS AN OVOID PORTION OF YELLON FATTY TISSUE MEASURING 3 X 1.7 X O.S CM. SECTIONING REVEALS GROSSLY FAT-REPLACRD NODAL TISSUE. THE SPECIMRN I8 ENTIRELY SUBMITTED LABELRD D. ProcKDurRs : 88307/4, IMMUNOPKROXIDAS/3, A BLK/12, BBX X6, CBX X6/3, DBX X6 PART A RIGHT SIMPLE MASTECTOMY: POORLY DIFFERENTIATKD INFILTRATING DUCT CARCINOMA, NUCLRAR GRADR II/III WITH A MODERATE MITOTIC INDEX. THE TOMOR IS 23 MM IN MAXIMUM MICROSCOPIC DIMENSION.  ARRAS OF POSSIBLE LYMPHATIC SPACE INVASICN ARK PRESENT, BUT THIS MAY ONLY BE RETRACTION ARTIFACT. ALL MARGINS ARE FRKE OF TUNOR BY DISTANCRS OF AT LRAST 20 MM. PARTS B, C, AND D RIGHT AXILLARY SENTINEL LYMPH NODES NUMBERS 1-3, BIOPSIES: LYMPH NODES WITH NO EVIDENCE OF MATASTATIC DISEASE, SUPPORTED BY NEGATIVE CYTOKBRATIN IMMUNOHISTOCHEMICAL STAINING. 1 Signed (prelim.) (signature on file)
\ No newline at end of file
diff --git a/output/text/d6f6fb37-6eb9-4d2a-90fb-754da8001cc8.txt b/output/text/d6f6fb37-6eb9-4d2a-90fb-754da8001cc8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5db94c3fe0fd3edebde7110ed2b290a31f16206b
--- /dev/null
+++ b/output/text/d6f6fb37-6eb9-4d2a-90fb-754da8001cc8.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+UUID : DEB67EB8-155C-4ACF-B3D4-595E4CBE2ESC TCgA-A7-A0CD-01a-pr Redacted /cs-0-3 carcnoma, nfiltratng duct, nos 8500/3 Sit: bruo$ Nus C50.9 pw jp3/4 SPECIMEN A. Sentinel node #1 B. Sentinel node #2 C. Left breast mass D. 6 o'clock E. 12 o'clock. E. 9 o'clock G. 3 o'clock REPORT REVISED ON AT CLINICAL NOTES HISTORy: Left breast ca at 10:00.  Multifocal 1 cm. and 5 cm. from nipple. REPORT REVISED ON AT 1 FROZEN SECTION DIAGNOSIS A) Lymph node, sentinel node 1, excision - Negative for metastatic carcinoma (0/1). B) Lymph node, sentinel node 2, excision - Negative for metastatic carcinoma (0/1). REPORT REVISED ON AT GROSS DESCRIPTION A.. Received fresh labeled "sentinel node #1" is a lymph node that measures 1.5 cm in dimension. The lymph node is entirely frozen. B. Received fresh labeled "sentinel lymph node #2 is a lymph node that measures 1 1 m 'n dimension. The lymph node is entirely frozen. C. The specimen is received fresh labeled "left breast mass" and. consists of a yellow piece of soft tissue measuring 10 x 7.5 x 5.4 cm. The specimen has a long and a short suture on it. There is an overlying
+
+--- Page 2 ---
+GROSS DESCRIPTION white ellipse of skin measuring 6.5 x 1.5 cm. which has a central longitudinal wound in it. The external surface of the specimen is inked as indicated below. Superior yellow, inferior orange, anterior red, lateral blue,. medial green, inferior black. There is a central firm tumor measuring 1.5 cm. in greatest cross sectional dimension. A portion of the central tumor is taken for research purposes. Sections after fixation. Rs15. +RR11 D. Received in formalin labeled "#6" and consists of a. yellow and tan piece of soft tissue measuring 3 x 2 x 0.7 cm. It is not completely clear which side of the specimen is the external side. The external surface of the specimen is inked.. Sections after fixation. Rs4. E. Received in formalin labeled "#12" and consists of a yellow piece of soft tissue measuring 3 x 2.5 x 1 cm. The external surface of the specimen is inked. Rs4.. F. Received in formalin labeled "g" and consists of a yellow piece of soft tissue measuring 3 x 1.5 x 1 cm..  The external surface of the specimen is inked. Sections after fixation.. RS2. G. Received in formalin labeled "#3" and consists of a piece of yellow soft tissue measuring 3.2 x 1.5 x 1 cm.. The external surface of specimen is inked. Sections after fixation.. RS3. REPORT REVISED ON AT MICROSCOPIC DESCRIPTION A. A single lymph node is negative for malignancy.. B. A single lymph node is negative for malignancy.. [At the request of some staff oncologists and in keeping with the opinion of some experts in breast pathology, immunohistochemical stains for keratin were not used on the. sentinel lymph node sections in this case. These stains can be obtained if. desired. Our paraffin blocks are retained for 10 years. (Schwartz. GF et al. Cancer 94(10):2542, 2002)].
+
+--- Page 3 ---
+C.  Invasive carcinoma Tumor type: Infiltrating ductal carcinoma. Tumor grade: 2 (Elston SBR grade; A/N/M =3/2/1 ) Mitotic index: 0 mitoses/10 HpFs (1 HPF = 0.196 sq mm) Tumor size: 1.5 cm. Specimen margins: Negative for malignancy. Carcinoma is 1 cm. from the nearest inked margin.. Vessel invasion: Absent.. Calcification: Absent. Non-tumorous breast: Apocrine metaplasia, cyst formation and intraductal epithelial hyperplasia without atypia are present. pTNM stage: T1 Prognostic markers:  See previous biopsy. D-G. Additional biopsy pieces are negative for. malignancy. Cyst formation and apocrine metaplasia are seen in specimen D at 6 o'clock. After discussion with Dr.. specimen C was re-examined. No definite second mass was identiried. An additional 11 blocks of tissue were submitted from the inferior portion of the specimen. These showed cyst formation (up to 2 mm), focal intraductal MICROSCOPIC DESCRIPTION epithelial hyperplasia without atypia, periductal elastosis, apocrine metaplasia, focal small cyst rupture, and arteriolar medial calcification. No additional carcinoma was identified. 4x3, 3x4, 14x2 REPORT REVISED ON AT
+
+--- Page 4 ---
+DIAGNOSIS A. Sentinel lymph node #l, biopsy: A single lymph node is negative for malignancy. B. Sentinel lymph node #2, biopsy: A single lymph node is negative for malignancy. C. Breast, left, excisional biopsy: Infiltrating ductal carcinoma, Elston sBR grade 2. Fibrocystic changes. D-G. Breast, left, 6 o'clock, 12 o'clock, 9 o'clock, 3 o'clock, biopsies: Mild fibrocystic changes. Negative for malignancy. Addition to microscopic description. REPORT REVISED ON AT , M.D. (Electronic Signature) - End Of Report.
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diff --git a/output/text/d7061d74-05b5-43a5-a9ac-a37bb688dbf2.txt b/output/text/d7061d74-05b5-43a5-a9ac-a37bb688dbf2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a4794fd45c0be713ffd0040e1f542548191a2e82
--- /dev/null
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+
+--- Page 1 ---
+UUID:5AEC5E5B-8EC4-4AA0-A195-612CFC38481F TCGA-4N-A93T-01A-PR Redacted SURGICAL PATHOLOGy REPORT Patient: Accession: DOB:  Sex: M Account: Age Date Collected: MRN:  Date Received: Patient I Requested by:  Date Reported: Clinical Data: Ascending coion mass final pathologic Diagnosis IcDO 3 Right colon with appendix, hemicolectomy: Two adenocarcinomas (proximal ascending and distal ascending colon). CdenxawwmdND S 8j4b]3 Cecal tubulovillous adenoma.. Unremarkable appendix. S.te: liseinddiy colens C18.2 Additional tubular adenomas are identified. All margins are negative for adenoma and malignancy.. AJ 3|zo|Jy SYNOPTIC REPORT Tumor site: Proximal ascending colon (larger mass) and distal ascending (smaller mass) Tumor size: 4.2 cm and 4.0cm Histologic type: Adenocarcinoma Histologic gra de: Low grade (moderately differentiated, G2) Extent of invasion:. Proximal ascending tumor invades serosal surface ; the more distal tumor invades through muscularis propria into pericolonic tissue. Tumor perforation: Not identified Margins: Uninvolved by invasive carcinoma (R0) Proximal margin: 24.5 cm (proximal tumor); 29cm (distal tumor) Distal margin: 9 cm (proximal tumor); 4.5cm (distal tumor) Circumferential radial margin:. 3 cm (proximal and distal tumor). Closest margin: Circumferential radial margin. Lymphovascular invasion: Absent Perineural invasion: Absent Treatment effect: No known prior treatment Regional lymph nodes: Two of twenty-five lymph nodes are positive for metastatic carcinoma (2/25) Pathologic Tumor Stage:. pT4a(m) pN1b Immunohistochemical stains for MLH-1, MSH-2, MSH-6 and PMs-2 reveal distinct nuclear staining for all markers. These findings indicate an intact mismatch repair (MMR) gene function without evidence of significant microsatellite instability (MSI) Aithough these findings make the diagnosis of hereditary non-polyposis colon cancer (HNPCC) or Lynch Syndrome very unlikely this patient, approximately 5% of colorectal carcinomas with defective MMR genes and high MSI may show this apparent normal pattern of staining. Correlation with the clinical findings & family history is encouraged. Page 1 of 2
+
+--- Page 2 ---
+SURGICAL PATHOLOGy REPORt - CONTInUED Result ID: Patient: Accession: Pathologist, Electronic Signature Specimen(s) suBmitteD: GrOss DEscriptiOn Right colon: in formalin labeled "right colon" is a 25 cm in length segment of cecum and right colon with an attached 20 cm of terminal ileum and a 6 cm attached appendix. Within the right colon there is a 4.2 x 4 cm endophytic tumor with raised rolled borders. This tumor is 9 cm from the distal margin and 24.5 cm from the proximal margin. The tumor invades into and through the bowel wall into the pericolonic fat and is grossly 3 cm from the circumferential soft tissue margin. The tumor also appears to  near the serosa/peritonealized surface of the attached fat. There is an additional 4 x 3 cm polypoid mass 4.5 cm from the distal margin and 29 cm from the proximal margin. The mucosa and wall adjacent to this mass is ragged, disrupted and hemorrhagic with hemorrhage and necrosis in the surrounding pericoloic soft tissues. No gross invasion beyond the wall is noted and this mass is 6 cm from the circumferential soft tissue margin. Within the cecum there is an additional 4.5 x 2.7 x 1.8 cm exophytic polypoid mass. This mass is 17 cm from the distal margin and 22 cm from the proximal margin. Again, no invasion through the several additional smaller, up to 0.6 cm, mucosal polyps and focal areas of congestion. The ileal mucosa is tan-pink with a few polypoid projections and a 2.3 x 1.3 cm flat granular area 6 cm from the proximal margin and 27 cm from the distal margin. No invasion into the mesenteric fat is noted and the lesion is 3.5 cm from the mesenteric resection margin. The cut surfaces of the  appendix display a lumen lined by congested mucosa. Multiple lymph nodes are identified in the attached fat. Representative sections are submitted as labeled: A-C tumor in ascending colon to pericolonic fat and serosal/peritonealized surface; D-E distal ascending colon polypoid mass with adjacent ragged hemorrhagic disrupted area; F-G cecal polypoid mass; H smaller colonic  mucosal polyps; I fiat and granular irregular area in small bowel; J small bowel mucosa with small polypoid projections; K distal margin and en face circumferential soft tissue margin; L proximal margin and appendix; M six lymph nodes; N six lymph nodes; O six lymph nodes; P six lymph nodes. Cpt coDe(s): ICD-9 CODE(S): FACILITY: 88342 x4, 88309, 8721 [1539] 1213 END OF REPORT
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diff --git a/output/text/d7134bd6-3c05-45c5-a8e8-b4e55b8357d2.txt b/output/text/d7134bd6-3c05-45c5-a8e8-b4e55b8357d2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c07784dac3bcc34a64c8dee07f63c88b58009cbe
--- /dev/null
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+
+--- Page 1 ---
+SURGICAL PATHOLOGY REPORT SPECIMEN Right hemicolectomy with en block resection of abdominal wall muscle and fascia. CLINICAL NOTES PRE-OP DIAGNOSIS: Tumor of cecum. POST-OP DIAGNOSIS:  Same. GROSS DESCRIPTION Received fresh for tissue procurement labeled "right hemicolectomy with en bloc" is a previously unopened, 24 cm segment of proximal right colon with attached 17 cm of distal ileum surfaced by smooth to scabrous. can-pink serosa with a moderate amount of attached mesocolon, mesentery and unremarkable omentum. An irregular 5 x 5 x 2.5 cm fragment of red-brown skeletal muscle is present in the vicinity of the cecal pouch. The cauterized surface of the portion of abdominal wall is inked blue (representing true surgical resection margin in that area). A scant amount of adherent omentum and retracted serosal surface are also present in the vicinity of the attached portion of abdominal wall (subsequently radial serosal surface). An unremarkable 7.2 cm in length, 0.9 cm in diameter appendix is  The proximal and distal margins measure 4 and 8 cm in circumference respectively.  On opening, there is a nearly. measuring 11.0 x 5.7 cm. On sectioning, the tumor has a maximal. thickness of 2.8 cm, grossly extending into the muscularis to within 0.5 cm of the inked cauterized resection margin (abdominal wall) (see paired contiguous sections blocks 2&3 and 4&5) and within 0.6 cm of the inked free radial serosal surface (see bisected contiguous sections block 6 and 7).  The ileal and remaining colonic mucosa is unremarkable glistening tan-pink with regular folds and the walls average 0.4 cm in thickness. Two palpable rubbery tan-pink-red apical lymph nodes averaging 1.3 cm in greatest dimension are. recovered from the attached mesocolon. Numerous additional rubbery pale tan lymph nodes, 2.8 cm in greatest dimension, are recovered from the remainder of the mesocolon and mesentery. A portion of tumor and a portion of normal mucosa are submitted for tissue. procurement as requeste presentative sections are submitted in 25 blocks as labeled.. BLOCK SUMMARY: and distal margins; 2&3, 4&5 - tumor to. inked cauterized abdominal wall margin and serosal surface with points of continuity inked red and green respectively; 6&7 bisected sections, tumor full thickness to inked free radial serosal surface, point of continuity inked black;.  tumor to proximal. mucosa/at Icv; 9&10 - additional bisected section of tumor to. abdominal wall (point of continuity inked violet); 11 - random ileum and colon; 12 - appendix; 13&14 - bisected apical lymph node (one bisected node per cassette); 15&16 - six whole lymph nodes per cassette; 17-21 - one bisected lymph node per cassette; 22&23 - one bisected lymph node (1/2 cassette); 24&25 - one bisected lymph node (1/2 per cassette).
+
+--- Page 2 ---
+MICROSCOPIC DESCRIPTION Histologic type: Adenocarcinoma, NOS. Histologic grade:  Moderately-differentiated. Primary tumor (pT): Tumor invades through the muscularis propria. into the serosal fat (pT3). Proximal margin:  Negative. Distal margin: Negative. Circumferential (radial) margin:  Negative. Vascular invasion: Negative. Regional lymph nodes (pN): 19 mesenteric lymph nodes are negative for metastatic carcinoma (0/19) (pN0). Non-lymph node pericolonic tumor: Absent. Distant metastasis (pM): pMx. Other findings: There is a large area of pericolonic abscess. formation and inflammatory activity present next to the tumor which has produced adhesion of the abdominal wall to the colon. No direct invasion by tumor is present at that site. Appendix without significant histopathologic finding. 5 DIAGNOSIS Terminal ileum, appendix, right colon and abdominal wall, en bloc resection: Invasive moderately-differentiated colonic adenocarcinoma. extending through the wall of the cecum into the serosal fat.. There are areas of abscess formation and inflammation between the abdominal wall and cecum producing adhesion of the abdominal wall to the colon. No direct invasion of this area by tumor is present. The proximal, distal and radial margins of resection are free of tumor.  Nineteen mesenteric lymph nodes negative for metastatic. carcinoma (0/19). Appendix without significant histopathologic. finding.  End Of Report
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diff --git a/output/text/d7a593c1-177b-4d79-b7af-4001f6d250cb.txt b/output/text/d7a593c1-177b-4d79-b7af-4001f6d250cb.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d6c9c1ce260bf4d58aff0a634ef135b15c75cba1
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+FInAL SuRgICAL pAThOLOgy REPOrt Diagnosis: Left KIdney And ureTer. NephreCTOMy: - INVASIVE PAPILLARY UROTHELIAL CARCINOMA, HIGH-GRADE - ARISING IN AND CONFINED TO RENAL PELVIS/CALICES. - SMALL FOC! OF INVASIVE CARCINOMA INVADING THE LAMINA PROPRIA.S - ADJACENT UROTHELIAL CARCINOMA IN SITU. - MARGIN STATUS: NEGATIVE. - VaSCUlAR, UreteRal, And GEROTa'S FASCIa margIn All NEgaTIVe. - NO LYMPH NODES IDENTIFIED. - BACKGROUND KIDNEy SHOWS PATCHy CHRONIC INTERSTITIAL NEPHRITIS. PATHOLOGIC TUMOR STAGING SUMMARY: - Histologic type and grade: Invasive (papillary) urothelial carcinoma, high-grade. - Primary tumor: pT1. - Regional lymph nodes: pNX. - Distant metastasis: pMX - Stage: pl. - Margin status: R0, negative. - Lymphovascular and perineural invasion: Not identified. COmmENT: Most of the tumor is non-invasive high-grade papillary urothelial carcinoma (3.7 cm in greatest dimension) but there are a few small foci of invasive. urothelial carcinoma (invading the lamina propria of the papillary stalk. up to 1 mm). The diagnosis is called to
+
+--- Page 2 ---
+FInAl SuRgICAL pAthOLOgy REPOrt Tumor Staging Information. (data derived from current specimen, staging in accordance with or modified from AJCC Cancer Staging Handbook, 7th Ed, and CAP protocol RENAL PELVIS: Regional lymph nodes: No nodes submitted or found.. Procedure: Nephrectomy with partial ureterectomy.. Specimen laterality: Left. Tumor size: 3.7 x 3.2 x 3.2 cm (Most of which is non-invasive papillary carcinoma, with a few small foci of invasive carcinoma invading the lamina propria measuring up to 0.1 cm). Histologic type: Urothelial (transitional cell) carcinoma.. Associated epithelial lesions:. Background of non-invasive papillary urothelia! carcinoma, high-grade. Histologic grade:. High-grade. Tumor configuration: Papillary. Margins: Margins uninvolved by invasive carcinoma (closest margin is Gerota's fascia at 1 cm; tumor is 1.5 cm from renal hilar vascular margins).. Lymphovascular invasion: Not identified. PATHOLOGIC STAGING (no TNM descriptors): Primary tumor: pT1, tumor invades subepithelial connective tissue (lamina propria). Regional lymph nodes: pNX. Distant metastasis: pMX. Additional pathologic findings:. Urothelial carcinoma in situ (high-grade itraurothelial neoplasia). Inflammation/regenerative changes (patchy chronic interstitial nephritis).
+
+--- Page 3 ---
+FINAL SURGICAL PATHOLOGy REPORT Source of Specimen:. Left Kidney and Left Ureter Clinical History/Operative Dx: Left renal pelvic tumor. Gross Description: The specimen is labeled left kidney and ureter and is received without fixative. It consists of a nephrectomy specimen with adherent long segment of ureter which weighs.  The nephrectomy specimen measures 14 cm from superior to inferior, 7.5 cm from medial to lateral, and 5 cm from anterior to posterior. There is no grossly identifiable adrenal gland tissue. Along the anterior surface of the kidney is a 8 x 5.5 cm area of thin delicate adherent tissue suggestive of Gerota's fascia. At the hilum the renal artery and renal vein are identified. The vessels are opened and show no gross evidence of intralumina! tumor. Extending from the hilum of the kidney is a 26 cm segment of ureter which proximally and. centrally has a diameter of 0.5 cm, up to 0.6 cm at the distal end. A yellow plastic stent is present in the Jumen of the ureter. The ureter is opened and the urothelium is tan and smooth. At the pelvis friable. tumor is present in the renal pelvis arising from the central calix. The kidney is bivalved to reveal a finely granular tan-white neoplasm occupying the superior pole calix and extending into the middle pole calix. This neoplasm overall measures 3.7 x 3.2 x 3.2 cm. It is approximately 1 cm from Gerota's fascia and 1.5 cm from the renal hilar vascular margin. It involves the upper pole and central pole calices. The inferior pole calix appears uninvolved. The renal parenchyma is otherwise reddish brown and cortical thickness is 0.6 cm. There are no obvious lymph nodes in the perinephric adipose tissue. Representative sections are submitted. Section summary: A1) surgical margin, renal artery, renal vein and ureter, A2) Gerota's fascia, A3) distal ureter, A4) mid and proximal ureter, A5) ureteropelvic junction, A6-A8) sections of tumor, A9) tumor in renal pelvis, A10) uninvolved kidney.. Microscopic Description: Microscopic sections have been examined. The microscopic findings are reflected in the diagnosiss. rendered.
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diff --git a/output/text/d7a64234-c905-469f-aeff-607b123bafb7.txt b/output/text/d7a64234-c905-469f-aeff-607b123bafb7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7c4dfb98846d6385252dcc6e6d3b99281c08a77e
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+
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+UUID:EC1BB6E8-6897-4E70-80A6-5A4E4B9C4E1F TCGA-A2-A3XY-01A-PR Redacted SURGICAL PATHOLOGY REPORT Patient: Specimen #: FMP/SSN:  DOB/Age/Sex: (Age: Race: Taken: Location: Received: Physician(s) : Reported: ic-o-3 **AMENDED** Carcinoma,snF iHg ting du<F,N0S 860OJ3 SPECIMEN: LEFT BREAST AXILLARY & CONTENTS FINAL DIAGNOSIS: pA4n'bseast, wppcr okr BREAST, LEFT, MASTECTOMY WITH AXILLARY DISSECTION: Guad?aM c5O,4  TUMOR TYPE: INVASIVE DUCTAL CARCINOMA (NO SPECIAL TYPE).  TUMOR FOCALITY: UNIFOCAL.  HISTOLOGIC GRADE: GRADE 3. NOTTINGHAM sCORE: 9/9 (Tubules= 3, Nuclei= 3, Mitoses= 3; mitotic count 24 PER 10 high power fields)..  TUMOR SIZE (GREATEST DIMENSION): 2.5 CM (GROSS MEASUREMENT).) TUMOR SIDE (QUADRANT) : LEFT, UPPER OUTER QUADRANT. TUMOR NECROSIS: PRESENT IN INVASIVE AND IN SITU CARCINOMA.  MICROCALCIFICATIONS: PRESENT IN DUCTAL CARCINOMA IN SITU AND BENIGN BREAST TISSUE. VENOUS/LYMPHATIC INVASION: NONE DEFINITELY IDENTIFIED. INTRADUCTAL COMPONENT: DUCTAL CARCINOMA IN SITU, NUCLEAR GRADE 3, SOLID TYPE WITH CENTRAL EXPANSIVE "COMEDO" NECROSIS.  MARGINS: DISTANCE OF INVASIVE CARCINOMA FROM CLOSEST MARGIN: 1.2 MM (SUPERFICIAL MARGIN). DISTANCE OF IN SITU CARCINOMA FROM CLOSEST MARGIN: I.O MM (SUPERFICIAL MARGIN) AND 1.2 MM (DEEP MARGIN). LYMPH NODES: 3 OF 17 NODES POSITIVE FOR METASTATIC CARCINOMA. LARGEST METASTATIC FOCUS: 1.2 CM (MICROSCOPIC MEASUREMENT).  EXTRACAPSULAR EXTENSION: ABSENT. NIPPLE INVOLVEMENT: ABSENT. SKIN INVOLVEMENT: ABSENT. PATHOLOGIC STAGE (AJCC EDITION) : pT2 N1a. ANCILLARY STUDIES: ESTROGEN RECEPTORS: NEGATIVE (O% NUCLEAR STAINING). PROGESTERONE RECEPTORS: NEGATIVE (O% NUCLEAR STAINING) HER2 BY FISH: NEGATIVE (HER2/CEP17 RATIO: 1.0; PER PERFORMED ON PRIOR SPECIMEN FROM ADDITIONAL PATHOLOGIC CHANGES: - PRIOR BIOPSY SITE CHANGES. Page 1 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OPS
+
+--- Page 2 ---
+FOR OFFICIAL USX ONLY - PRRSONAL DATA - PRIVACY ACT OF SURGICAL PATHOLOGY REPORT Specimen #: Patient: FINAL DIAGNOSIS (continued): - FIBROADENOMA (1.2 CM; MICROSCOPIC MEASUREMENT).  USUAL DUCTAL HYPERPLASIA, MODERATE.  SMALL PERIPHERAL PAPILLOMA. - FIBROCYSTIC CHANGES. Comment: This case is amended  to add the results of immunohistochemical stains for estrogen and progesterone receptors, as noted above. No other changes are made. Although eR and pR stains were previously performed on the patient's core biopsy  they were repeated due the greater number of neoplastic cells in the current specimen and due to the focal staining for. progesterone receptors (reportedly 1%) in the prior biopsy.. Estrogen and progesterone receptors were evaluated by immunohistochemical methods ( estrogen receptor antibody 1D5, progesterone receptor. antibody PgR636). A positive test is defined as easily discernable nuclear staining in 1% or more of the tumor cells. #  Report Electronically Signed Out * CLINICAL DIAGNOSIS AND HISTORY: Diagnostic -yearoold with left breast mass in I confirmed presence of a 2.2 x mammography and ultrasound on 1.4 cm left upper outer quadrant breast mass. PRE-OPERATIVE DIAGNOSIS: Left breast mass; breast cancer. POST-OPERATIVE DIAGNOSIS: None provided.. GROSS DESCRIPTION:  and Received fresh, labeled with the patient's name. designated, "Left Breast Axillary and Contents" and consists of a left mastectomy oriented with a short stitch superior; two short stitches The posterior; one long lateral; and two long on an axillary lymph node. 15.0 specimen weighs 381 grams and measures 17.0 cm medially to laterally; Page 2 Continued on Next Page. FOR OFPICIAL USR ONLY - PBRSONAL DATA - PRIVACY ACT OF
+
+--- Page 3 ---
+VOR OPFICIAL USR ONLY - PERSONAL DATA - PRIVACY ACT O SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION (continued) : cm superiorly to inferiorly; and 2.5 cm anterior to posterior. The darkly pigmented superficial skin ellipse measures 15.5 x 5.5 cm and displays a 1.5 x 1.0 x 1.0 cm centrally located, everted nipple, free of discharge. The deep margin is inked black and the superficial margin is inked blue. Serial sections reveal a fairly well defined, firm pink-tan mass in the upper outer quadrant. The mass measures 2.5 x 1.4 x 0.4 cm, comes to within 0.4 cm of the deep margin and abuts the superficial margin. Immediately adjacent to, and continuous with the mass, is a 0.4 cm centrally located, red-brown probable biopsy cavity. A 1.2 x 1.2 x 0.5 cm well-circumscribed, rubbery fibrous nodule is noted in the lower mid. breast which is consistent with a fibroadenoma. The remainder of the. specimen is composed of markedly dense tan-white fibrous tissue with. minimal admixed adipose tissue. No additional lesions are identified. The attached axillary tail measures 8.0 x 6.5 x 2.0 cm. Sectioning. reveals 11 lymph nodes ranging in size from 0.3 cm in greatest dimension to 2.5 x 2.0 x 1.7 cm. On sectioning, the two largest lymph nodes, one of which is tagged with a suture, are tan-white and moderately firm, consistent with involvement by metastatic lesion.. Representative sections are submitted as follows: 1- nipple; 2- mass with deep margin; 3- mass with superficial margin; 4- mass with deep margin; 5- mass with superficial margin; 6-7- mass with deep margin; 8-9- mass with superficial margin; 10- mass; 11- biopsy cavity; 12- biopsy cavity; 13- lower mid nodule; 14- uIQ; 15- LIQ; 16-'L0Q; 17; central' (adjacent'to. mass); 18- one lymph node (marked with suture); 19- five lymph nodes; 20- one lymph node; 21- one lymph node, bisected; 22- one lymph node; 23- one lymph node; 24-25- one lymph node, sectioned. Matched sections of 1,5,8-10, 12-18, 20 and 22-24 are submitted in ocr/Paraffin per Time in formalin: >80 hours. Page 3 End of Report. FOR OFFICIAL USB ONLY - PERSONAL DATA - PRIVACY ACT OF
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diff --git a/output/text/d7aa437b-6390-401a-90d4-bb6703b9931b.txt b/output/text/d7aa437b-6390-401a-90d4-bb6703b9931b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b08ead1f9a6701be4d4c87619d3bb978bcf307be
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+
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+Specimen(s) Received 1. Oral-Cavity: rt.tongue lesion 2. right glossectomy ( stitch = anterior) 3. floor of mouth margin ( stitch = anterior). 4. superior margin ( stitch= anterior) 5. posterior margin ( stitch superior) Diagnosis 1-2. Right tongue; resection:  Squamous cell carcinoma, spindle cell (sarcomatoid) variant, poorly differentiated (see comment).  Maximum tumor dimension 3.2 cm.. a. b. Maximum tumor thickness 1.5 cm. C.  No perineural invasion identified.. d. No lymphovascular invasion identified.. e.  Tumor is present close (0.3 cm) to lateral and deep resection margins. f.  All other margins negative for tumor (> 0.5 cm). 3. Floor of mouth margin: - Squamous mucosa, negative for malignancy. 4. Superior margin: - Squamous mucosa, negative for malignancy. 5. Posterior margin:. - Squamous mucosa, negative for malignancy. Synoptic Data Specimen Type: Resection:Right tongue. Tumor Site: Tongue Histologic Type: Spindle cell carcinoma.
+
+--- Page 2 ---
+Tumor Size: Greatest dimension: 3.2 cm Tumor thickness: 1.5 cm. Histologic Grade: G3: Poorly differentiated. Venous/Lymphatic (Large/Small Vessel) Invasion (V/L): Absent Perineural Invasion: Absent Additional Pathologic Findings: Epithelial dysplasia Margins: Margins uninvolved by tumor - Distance of tumor from closest margin: 0.3 cm Margins: lateral and deep margins Pathologic Staging (pTNM): pT2: Tumor of lip or oral cavity more than 2 cm but not more than 4 cm in greatest dimension pNX: Regional lymph nodes cannot be assessed for aerodigestive sites. pMX: Distant metastasis cannot be assessed. Comment The specimen is received in two parts. There is a polypoid lesion, which is made up of spindled and epithelioid dyscohesive cells that show a high mitotic activity and pleomorphism, consistent. with high-grade spindle cell neoplasm. Foci within this polyp also show typical squamous cell carcinoma. The second specimen is made up of a large area of squamous dysplasia with early invasive conventional squamous cell carcinoma, moderately differentiated. The conventional squamous cell carcinoma is seen within 0.3 cm of the lateral and deep margins. The sarcomatoid. carcinoma component is largely confined to the exophytic polyp and is not seen near the margins.. The tumor thickness of the early invasive component is 0.3 cm, however the total thickness taking into account the polypoid lesion is 1.5 cm. Clinical History oral tongue cancer Gross Description 1. The specimen is labeled with the patient's name and as " Oral cavity: rt tongue lesion'. It consists of an unoriented piece of oval, tan, firm mass with smooth surface, measuring 2.8 x 2.0 x 1.5 cm. On cut surface, tumor is tan white and homogenous. There is a pedicle measuring O.5 x 0.5 cm. Specimen was cut by for tumor bank and not painted. Specimen is submitted in toto in blocks 1A through 1E. 2. The specimen is labeled with the patient's name and as "Rt glossectomy (stitch=anterior)". It consists of a portion of tongue measuring 4.6 x 3.2 x 2.3 cm. There is a stitch on the anterior margin. There is a tumor involving the lateral surface of the tongue. It is grey white in colour, hard in consistency, and has a dull surface. There is a small ulcerated area (? area of pedicle), which is 0.4 cm away from anterior margin and measures 0.5 x 0.5cm. The tumor measures 3.2 (AP) x 2.0 cm (Sl) x 0.3 cm (ML/ deep). The tumor is 0.3 cm away from superior, 0.5 cm away from inferior, 0.4 cm away from anterior, 1.0 cm away from posterior, and 1.5 cm away from medial margin. Specimen is painted with silver nitrate and marked with green ink on supero- medial aspect. Representative sections are submitted. 2A- Anterior margin (perpendicular) with tumor 2B- posterior margin (perpendicular) with tumor. 2C- full thickness tumor with superior, medial, and inferior margins
+
+--- Page 3 ---
+2D- 2F tumor 3. The specimen is labeled with the patient's name and as "floor of mouth margin. (stitch=anterior)". Submitted in toto for research. 3A  frozen section control 4. The specimen is labeled with the patient's name and as "superior margin (stitch anterior)" Submitted in toto for research. 4A  frozen section control 5. The specimen is labeled with the patient's name and as "posterior margin (stitch superior)".. Submitted in toto for research. 5A  frozen section control Quick Section Diagnosis 3A. Floor of mouth margin (stitch=anterior): Negative for malignancy.. 4A. Superior margin (stitch=anterior): Negative for malignancy.. 3A. Posterior margin (stitch=superior): Negative for malignancy..
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+UUID:F8254D81-8345-4799-9A39-56F06E88DFF5 TCGA-KQ-A410-01A-PR Redacted Surgical Pathologv Laboratory al Pathology Report Report Date: Submitted by: Telephone: Location: Copy 'To: CLINICAL INFORMATION: Urothelial carcinoma of the bladder. Radical cystoprostatectomy. Specimen submitted: A. Right pelvic lymph node; B. Bladder, prostate, seminal vesicles; C. Right pelvic lymph node; D. Left pelvic lymph node; E. Left distal ureter; F. Right distal ureter DIAGNOSIS: A. Pelvis, right, lymph nodes (excision): Nodular deposits of urothelial carcinoma in fibroadipose (lymph node replacement cannot be excluded). B. Bladder, prostate, seminal vesicles (resection): Bladder: - High grade, papillary urothelial carcinoma with focal micropapillary pattern, 6.0 cm, involving entire bladder (all walls). - There is multifocal invasion of muscularis propria and focal extension into perivesical tissue. - Lymphatic (B4, B9) and venous (B8) invasion is identified. - Multifocal urothelial carcinoma in situ of bladder, extending into the distal ieft ureter and bladder neck. - Ulcers with foreign body giant cell reaction, consistent with previous biopsy sites. - Margins of resection, including urethral and ureteral, are negative for invasive carcinoma. - One Iymph node, negative for metastatic carcinoma (0/1). - TNM staging: pT3, N1, MX (See specimen C below.) Prostate: Benign prostatic hyperplasia with acute and chronic inflammation. Histologically unremarkable seminal vesicles. C. Pelvis, right, lymph nodes (excision):  Highgrade urothelial carcinoma with micropapillary pattern in fibroadipose tissue suggestive of  metastatic carcinoma replacement of lymph node. icD-o-3 pa' untneigl carcinoma. D. Pelvis, left, lymph nodes (excision): papiliary 8130]3 Ten lymph nodes, negative for metastatic carcinoma (0/10). cqcf: urshlia1 car<inomg, E. Ureter, left, distal (excision):. Nos 8{zoj3 Urothelial carcinoma in situ of dilated ureter.. 7-23-12  Page I of 3 RO
+
+--- Page 2 ---
+F. Ureter, right, distal (excision): Benign dilated ureter. GROSS DESCRIPTION: A. Received fresh, the specimen is labeled "right pelvic lymph node," and consists of a 3.5 x i.2 x 0.5 cm piece of fibromuscular tissue with two lymph nodes, both of which are entirely frozen. The remaining tissue is entirely submitted. Summary of sections: AFSC-lymph nodes; A1-remaining tissue. B. Received fresh, the specimen is labeled *bladder, prostate and seminal vesicles," and consists of a cystoprostatectomy specimen measuring 14.0 x 9.0 x 5.5 cm. The prostate measures 5.5 x 4.5 x 3.5 cm and the bladder measures 7.0 x 5.5 x 4.5 cm. The right seminal vesicle measures 2.0 x 1.5 x 1.5 cm, the left seminal vesicle measures 3.5 x l.5 x 1.0 cm, the right vas deferens measures 5.0 x 0.5 cm and the left vas deferens measures 8.0 x 0.4 cm. The left ureter measures 2.0 x 0.9 cm and the right ureter measures 1.8 x 1.0 cm. Both ureters are shaved and submitted. The distal urethral margin is shaved and submitted. The right aspect of the prostate is inked green and the left aspect of the prostate is inked black. The anterior perivesical fat is inked green and the posterior perivesical fat is inked black. The bladder is opened anteriorly to reveal a fungating tumor measuring 6.0 x 5.5 x 3.0 cm located at the left dome, left lateral wall and anterior wall. No tumor grossly extends outside of the muscle. Additionally, there are multiple erythematous polypoid lesions on both right and left lateral and posterior walls measuring up to 1.2 cm. The prostate is serially sectioned and sections are labeled from A through H from apex to bladder neck. On cut section, the prostate shows multiple cystic and nodular areas and is otherwise unremarkable. The prostate is submitted in alternating sections and representative sections of the bladder including tumor are submitted. Summary of sections: B1-distal urethral margin; B2-right ureter margin; B3-left ureter margin; B4-right ureterovesical junction; B5-left ureterovesical junction; B6-trigone of bladder to prostatic urethra; B7-trigone to right wall; B8-left wall; B9-right wall; B10 and B1I-posterior wall; B12-dome; B13-right and posterior wall; B14-anterior wall; B15-deep to B14; B16-left wall; B17-section adjacent to B16; B18-anterior wall; B19-left wall; B20-anterior wall; B21-section deep to B20; B22-? tumor in fat near left wall; B23 and B24-additional perivesical fat; B25-RA apex; B26-RP apex; B27-LA apex; B28-LP apex; B29-ARA; B30-ARP; B31-ALA; B32-ALP mid; B33-ALP lateral; B34-CRA; B35-CRM; B36-CRP; B37-CLA; B38-CLM; B39-CLP; B40-ERA; B41-ERM; B42-ERP; B43-ELA; B44-ELM; B45-ELP; B46-GRA mid; B47-GRA Iat; B48-GRP mid; B49-GRP lat; B50-GLA; B51-GLP. C. Received fresh, the specimen is Iabeled "right pelvic lymph nodes," and consists of a 4.0 x 3.5 x 0.5 cm piece of fibromuscular tissue and possible lymph nodes. The specimen is entirely submitted. Summary of sections: C1 through C3-fibromuscular tissue which is firm, ser'a!ly sectioned and entirely submitted; C4-remaining tissue. D. Received . - t, the specimen is labeled "teft pelvic lymph nodes," and consists of a 3.8 x 2.5 x 1.0 cm aggregate of lymph nodes and fibrofatty I sue v - + is entirely submitted. Summary of sections: Di through D3. E. Received fresh,! I is labeled "left distal ureter," and consists of a 2.2 cm segment of ureter up to I.! cm in diameter. One end is clipped an. site end is taken as the true margin. Representative sections of the remaining ureter are submitted. Summary of sect. ons: t 1-true argin; E2-representative sections. F. Received fresh n -- :cimen is labeled "right distal ureter," and consists of a 5.3 cm segment of ureter measuring up to 0.7 cm in diameter. One d and the opposite end is taken to be the true margin. Representative sections of the remaining ureter are submitted. : Rsons: F1-true margin; F2-representative sections. ( INTRAOPERATIVE D.  SNOSIS: A. Frozen section diagnosis:. Positive for carcinoma.1 Reported to: *** Electronically Signed Out **** Attending Pathologist The attending pathologist whose signalure appcars on this report has reviewed the diagnostie stides, and has edited the gross and microscopic portians of the report in rendering the linal diagnosis. Page 2 of3
+
+--- Page 3 ---
+Slides: A-3, B-51, C-4, D-3, E-2, I-2 END OF REPORT Page 3 of 3
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index 0000000000000000000000000000000000000000..5fc6713410b8bb18512b28dc5ed9d21ac0cae32a
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+--- Page 1 ---
+Sh. hreast NUs. c50.9 1/25/ h Surg Path UUID:BACD8008-F320-472C-ACFF-175E9F525E9F TCGA-B6-A0WT-01A-PR Redacted CLINICAL HISTORY: Not provided.. GROSS EXAMINATION: A. "Left breast biopsy (AF1)", fresh. A 7 x 4.9 x 1.7 cm yellow-white fibrofatty breast biopsy notable for a 2.5 x 3.5 x 2 cm firm, white lesion. After consultation with Dr. , it was deemed that no surgical margins. or orientation are required on this specimen. The tissue surface is inked in black, however. Tissue from the lesion is sent to the Tissue Bank for Estrogen and Progesterone receptor study. The frozen section remnant (AFl) was taken from the lesion area is submitted in Block Al. A representative sampling from the lesion area is submitted in Blocks A2-A5. Due to the fact that neither margins or orientation is an issue in the specimen, only a sampling of the lesion is taking-- the entire breast biopsy is not submitted. B. "Left breast", fresh. A mastectomy specimen consisting of a 19 x 10 cm ellipse of skin, a 24 x 15 x 5 cm breast and a 11 x 6 x 3.5 cm axillary tail. The deep surfaces of the breast are inked in black. The skin ellipse contains the nipple and surrounding areola and is notable for a 4.5 cm freshly sutured horizontal incision medial to the nipple.. The breast specimen is notable for a 7 x 6 x 1.5 cm hollow biopsy cavity lined by mildly firm, granular red-pink tissue 0.1 cm thick. At its closest point, the biopsy cavity is 1.5 cm from the posterior surface, 1.7 cm from the inferior surface, 9 cm from the superior surface, and 1.2 cm from the overlying anterior skin surface. The remainder of breast is diffusely composed of yellow-white fibrofatty tissue. No focal lesions are noted. BLOCK SUMMARY: Bl- representative section of nipple.. B2- representative section of biopsy cavity and closest approach to posterior surface. B3- representative section of biopsy cavity and closest approach to inferior surface. B4- biopsy cavity and closest approach to anterior skin surface. B5-B6- additional sections of biopsy cavity.. B7-B8- representative sections of upper medial portion of breast. B9-bi0- representative sections of lower medial portion of breast. B11-B12- representative sections of upper lateral breast. B13-b14-- representative sections of lower portion of breast. B15- four lymph node candidates from most medial portion of axillary tail. B16- four lymph node candidates from mid portion of axillary tail.. B17- three lymph node candidates from most lateral portion of axillary tail. B18- three lymph node candidates from most lateral portion of axillary tail. B19- three lymph node candidates from most lateral portion of axillary tail. Dr. INTRA OPERATIVE CONSULTATION: A. "Left breast biopsy": AFl- positive for invasive carcinoma DIAGNOSIS : A. "LEFT BREAST BIOPSY": INFILTRATING DUCTAL CARCINOMA, HISTOLOGIC GRADE 3, NUCLEAR GRADE 2 N.S.A.B.P.. Diagnos yfumo
+
+--- Page 2 ---
+MAXIMUM TUMOR SIZE 3.5 CM. IN SITU DUCTAL COMPONENT REPRESENTS APPROXIMATELY 15 TO 20% OF TUMOR MASS. B. "LEFT BREAST" (MASTECTOMY) : BREAST TISSUE WITH BIOPSY CAVITY. NO EVIDENCE OF MALIGNANCY.S 1 OF 15 LYMPH NODES POSITIVE FOR METASTATIC CARCINOMA (SEE NOTE). BENIGN PROLIFERATIVE CHANGES OF THE BREAST INCLUDING EXTENSIVE FIBROSIS, NoTe: One large lymph node (B18)appears negative for malignancy but is being reprocessed for further examination. An addendum will be issued to this report documenting the findings in this.. Verified by:. Date Signed: ADDENDUM 1: Review of a reprocessed blocks (B18) shows three lymph nodes with no evidence of malignancy. The one large lymph node mentioned in the original report specifically contains no eyidence of malig. Icy. Verified by vate Signed:
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diff --git a/output/text/d7df163a-7378-441b-9706-89a6ce3fe98e.txt b/output/text/d7df163a-7378-441b-9706-89a6ce3fe98e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0c33707d82d745ada41a42cee9d14a5b9a1210da
--- /dev/null
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@@ -0,0 +1,9 @@
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+Page 1 of 3 MRN Name Encounter Number COPY ONLY DO NOT FILE SURGICAL PATHOLOGY Time Collected Time Received Time Reported Order Number Ordering Provider Status Results Final Source of Specimen LEFT KIDNEY AND ADRENAL GLAND- FINAL DIAGNOSIS: LEFT KIDNEY AND ADRENAL GLAND- RENAL CELL CARCINOMA WITH EXTENSIVE NECROSIS AND HEMORRHAGE (See synoptic report below). MINUTE (LESS THAN O.1 CM) CORTICAL FOCUS OF PAPILLARY CHANGE (SLIDE A12), NOT DEFINITE FOR TUMOR. SYNOPTIC REPORT: RENAL CELL CARCINOMA, LIMITED TO KIDNEY/RENAL TISSUE EXAMINED PROPORTION OF SARCOMATOID COMPONENT: O % SPECIMEN LATERALITY: LEFT TUMOR FOCALITY: FOCAL TUMOR SIZE: 9 X 9 X 6 CM HISTOLOGIC TYPE: PAPILLARY GRANULAR CELL TYPE HISTOLOGIC GRADE (FUHRMAN NUCLEAR GRADE) : 2/4 TNM STAGE: Prepareo
+
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+Page 2 of 3 LYMPH NODE(S) INCLUDED IN ALL PARTS: NUMBER INVOLVED : 0 NUMBER EXAMINED: 0 LYMPHATIC (SMALL VESSEL) INVASION: NOT FOUND SPECIMEN TYPE: RADICAL NEPHRECTOMY SPECIMEN SIZE: 22 X 15 X 11 CM ADRENAL GLAND, NEGATIVE FOR TUMOR NO TUMOR SEEN AT SPECIMEN MARGINS Case Clinical  Information LEFT RENAL MASS Gross Description Received in formalin labeled with the patient's name and "left kidney and adrenal gland" consists of a 1060 gram total. nephrectomy specimen with attached perinephric fat and attached adrenal gland. Overall the dimensions of the specimen measure 22 x 15 x 1l cm. The kidney proper measures 15 x 10.5 x 6.5 cm. The ureter is identified at the hilum measuring 1.0 cm. The remainder of the vessels. at the hilum are identified with clamps. The attached adrenal gland has a somewhat disrupted appearance measuring 5 x 1.5 x 1.0 cm. The cut surface of the. adrenal gland has a gold-yellow appearance. The kidney is bivalved and in the  upper pole the cut surface reveals a capsulated necrotic mass 9 x  9 x 6 cm and grossly appears to push the capsule in the area of the mass. The cortex in the lower pole has a tan smooth appearance measuring 1.1 cm. The mass measures to the Up junction 2.9 cm. Further serially sectioning the mass has a very friable necrotic hemorrhagic appearance. Representative sections are submitted as follows: A1 = left ureter remainder of vessels at. hilum; A3-A4 full thickness cross sections of  attached adrenal gland; A5-A6 full thickness cross sections of Up junction;. A7-A9 full thickness  cross sections  demonstrating mass, capsule  and and fatty tissue; A10-A12 = full thickness cross sections  of parenchyma lower pole that is not involved. Also was taken research. Additional section code:. A13-Al6= full thickness cross sections  of tumor to kidney and Pre
+
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+Page 3 of 3 dure A. AA ROUTINE H&E X1 BLOCK.1 H&E X1 A. AA ROUTINE H&E X1 BLOCK.2 H&E X1 A. AA ROUTINE H&E X1 BLOCK.3 H&E Xl A. AA ROUTINE H&E X1 BLOCK.4 H&E X1 A. AA ROUTINE H&E X1 BLOCK.5 H&E X1 A. AA ROUTINE H&E X1 BLOCK.6 H&E X1 A. AA ROUTINE H&E X1 BLOCK.7 H&E X1 A. AA ROUTINE H&E X1 BLOCK.8 H&E X1 A. AA ROUTINE H&E X1 BLOCK.9 H&E X1 A. AA ROUTINE H&E X1 BLOCK.10 H&E X1 A. AA ROUTINE H&E X1 BLOCK.11 H&E X1 A. AA ROUTINE H&E X1 BLOCK.12 H&E X1 A. AA ROUTINE H&E X1 BLOCK.13 H&E X1 A. AA ROUTINE H&E X1 BLOCK.14 H&E X1 A. AA ROUTINE H&E X1 BLOCK.15 H&E X1 A. AA ROUTINE H&E X1 BLOCK.16 H&E X1 Prep
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diff --git a/output/text/d7e1220b-2615-40ee-b66a-6f800e6aced0.txt b/output/text/d7e1220b-2615-40ee-b66a-6f800e6aced0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d8c8cd11d7cd5767e10b549e92984b2cd57beb9e
--- /dev/null
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+--- Page 1 ---
+1cd-0-3 Carcinma. nfiltratwy owct,NOs 8500|3 12810 C50.9 Site Codu: brsst, nos UUID: 8F8DCA87-B27A-429C-952A-186F8D4502AE TSS: TCGA-E2-A154-01A-PR Redacted SPECIMENS: A. SENTINEL LYMPH NODE #1 LEFT AXILLA B. SENTINEL LYMPH NODE #2 LEFT AXILLAE C. LEFT BREAST WLE SPECIMEN(S): A. SENTINEL LYMPH NODE #1 LEFT AXILLA B. SENTINEL LYMPH NODE #2 LEFT AXILLAE C. LEFT BREAST WLE GROSS DESCRIPTION: A. SENTINEL LYMPH NODE #1 LEFT AXILLA Received fresh labeled with the patient's identification and "SLN #1, left axilla" is a 2.0 x 1.5 x 0.5 cm possible lymph node. The tissue is serially sectioned and touch imprints are performed. The specimen is entirely submitted, A1-A2 B. SENTINEL LYMPH NODE #2 LEFT AXILLA Received fresh labeled with the patient's identification and "SLN #2, left axilla" is a 1.6 x 1.4 x 0.4 cm possible lymph  node. The tissue is serially sectioned and touch imprints are performed. The specimen is entirely submitted, B1. C. LEFT BREAST Received fresh and subsequently placed in formalin labeled with the patient's identification and "left breast" is an oriented (short-superior, long-lateral) 26 gm, 5.8 x 5.1 x 1.8 cm lumpectomy. Ink code (previously inked in OR):.  anterior-yellow, posterior-black, medial-green, lateral-red, superior-blue, inferior-orange. The specimen is serially sectioned into seven slices revealing a 1.5 x 1.5 x 1.3 cm stellate, gritty white tumor that is closest to the anterior. margin at less than 0.1 cm. Tissue is procured. Also, identified is a second 0.5 x 0.4 x 0.2 cm, firm tan-white. suspicious nodule that is closest to the inferior margin at 0.2 cm. The second nodule is at least 0.4 cm inferior to the. tumor. No additional masses are identified. Representative sections:. C1-C2-slice 7. inferior margin, perpendicular C3-slice 6, tumor-lateral half. C4-slice 6, tumor-medial half C5-slice 5, tumor to anterior margin C6-C7-slice 4, tumor to anterior and posterior margins. C8-slice 2, representative posterior and lateral margins C9-slice 1, superior margin, perpendicular DIAGNOSIS: A. LYMPH NODE, SENTINEL #1, LEFT AXILLA, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (O/1). B. LYMPH NODE, SENTINEL #2, LEFT AXILLA, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (O/1) C. BREAST, LEFT, WIDE LOCAL EXCISION: - INVASIVE DUCTAL CARCINOMA, SBR GRADE 2, MEASURING 1.2-CM - SATELLITE INVASIVE TUMOR, MEASURING 1 MM, PRESENT 2.5 MM FROM POSTERIORE - INVASIVE TUMOR PRESENT AT ANTERIOR SURGICAL RESECTION MARGIN SURGICAL RESECTION MARGIN - INTERMEDIATE NUCLEAR GRADE, DUCTAL CARCINOMA IN SITU, CRIBRIFORM TYPE WITH FOCAL NECROSIS - SEE SYNOPTIC REPORT. SYNOPTIC REPORT - BREAST Specimen Type: Excision Needle Localization: No Laterality: Left Invasive Tumor. Present Multifocality: Yes WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Tumor size: 1.2cm Margins: Involved at anterior Extent:: 4 mm Tubular Score: 2
+
+--- Page 2 ---
+- METASTATIC CARCINOMA TO ONE OF TWELVE AXILLARY LYMPH NODES (1/12), MEASURING 3.5-CM WITH FOCAL EXTRANODAL EXTENSION - METASTATIC CARCINOMA TO ONE OF TWO INTRAMAMMARY LYMPH NODES (1/2), MEASURING O.8-CM WITH FOCAL EXTRANODAL EXTENSION - SEE SYNOPTIC REPORT AND SEE NOTE B. LYMPH NODES, ADDITIONAL LEFT AXILLARY CONTENTS, DISSECTION: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1).  NOTE: Four tumor nodules are grossly identified. Microscopically 3 of them are invasive ductal carcinoma that have the same morphology and one is DCis. The tissues in between these nodules show scattered foci of DCIS.. Therefore, these foci may be interconnected through DCis. Largest confluent invasive tumor measures 2.5-cm. Two intramammary lymph nodes are identified, one is positive for metastatic carcinoma SYNOPTIC REPORT - BREAST Specimen Type: Mastectomy Needle Localization: No Laterality: Left  Invasive Tumor: Present Multifocality: Yes  WHO CLASSIFICATION  Invasive ductal carcinoma, NOS 8500/3 Tumor size: 2.5cm Tumor Site: Upper inner quadrant Lower inner quadrant Margins:  Negative Tubular Score: 3 Nuclear Grade: 2 Mitotic Score:  3. Modified Scarff Bloom Richardson Grade: 3 Necrosis: Absent Vascular/Lymphatic Invasion: Indeterminate Lobular neoplasia:  None Lymph nodes: Axillary dissection Lymph node status: Positive 2 / 15 Extranodal extension DCIS present DCIS Quantity: Estimate 10% DCIS Type: Solid Cribriform DCIS Location:Associated with invasive tumor Nuclear grade: High Necrosis: Present ER/PR/HER2 Results ER: Positive PR: Negative HER2: Negative by IHC Performed on Case: Pathological staging (pTN): pT 2 N 1c CLINICAL HISTORY:  None given PRE-OPERATIVE DIAGNOSIS: Left breast cancer  Microscopic/Diagnostic Dictation: Pathologist Final: Pathologist, 1 Criteria Yes Diagnosis Discrepanc
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diff --git a/output/text/d81d12bd-b014-473c-aa22-450a3e490916.txt b/output/text/d81d12bd-b014-473c-aa22-450a3e490916.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b2c5853053fda2312ac0c09ac504bfbf79b8a26d
--- /dev/null
+++ b/output/text/d81d12bd-b014-473c-aa22-450a3e490916.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TCGA #: Sample ID #: Diagnosis: 1. Chronically fibrosing cholecystitis, with reactive hyperplasia of a local lymph node. 2. Tumor-free fatty tissue.. 3. Resected colon with a centrally ulcerated, moderately differentiated. adenocarcinoma of the colorectal type, located 1.5 cm from the aboral resection margin, and with wide infiltration of the pericolic fatty tissue as well as with four local lymph node metastases. Tumor-free colon resection margins. Tumor-free. mesocolic resection margin. Also diverticulosis coli.. Stage of tumor: pT3 pN2 (4/35) pMX; G2, L1, V0, local R0 1cs-0-3 adunocaiciiomc,N1s 8140/3 S#t: sigmstd clon (pw cQcr) c18.7 lu 3/30/n UUID:0D66971E-D224-4536-A3BE-B138861D8E7D TCGA-AA-A01K-01A-PR Redacted
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diff --git a/output/text/d8481100-38b4-401b-9927-b036e0a312f8.txt b/output/text/d8481100-38b4-401b-9927-b036e0a312f8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..73d91faaecac173448614e01d8d404225e1f8e99
--- /dev/null
+++ b/output/text/d8481100-38b4-401b-9927-b036e0a312f8.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis/ diagnoses Resected section of colon (transverse colon) with a colon carcinoma characterized. histologically as a moderately differentiated, partially mucinous colorectal adenocarcinoma, located at the base of a tubulovillous adenoma with severe epithelial dysplasia (synonymous: profound intraepithelial neoplasia), extending a max of 5 cm to a. resection margin and measuring 2 cm in diameter at the widest point. Invasive spreading of. the tumor to the submucosa level.. Located 4 cm from the same resection margin there is a microscopically small section or remains of an adenoma of the colon mucosa, tubular in form and with slight epithelial dysplasia (synonym: mild intraepithelial neoplasia). In addition, in the centre of the preparation there is a microscopically small tubular adenoma of the colon mucosa or remains of an adenoma with moderate epithelial dysplasia (synonym: mild intraepithelial neoplasia). Oral and aboral resection margins are tumor-free as is the greater omentum. 18 mesocolic lymph nodes are tumor-free with uncharacteristic reactive lesions. Therefore the tumor stage is pT1 pN0 (0/18) L0 V0 R0; G2
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diff --git a/output/text/d8495227-089e-4e5e-9727-c456d695c6c7.txt b/output/text/d8495227-089e-4e5e-9727-c456d695c6c7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..388d404afffdcd37e6ee5428cdc01f48deafc769
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+M1 CLINICAL DIAGNOSIS : Pancreatic Cancer ZCD-O-3 FROZEN DIAGNOSIS : enscaicenosgy dectx0S s Fro 1) R/O liver mass, biopsy: Mesothelial cell hyperplasia 8500/3) tubuloppislarey Fro 2) R/O peritoneal seeding #1, biopsy: Negative Fro 3) R/O peritoneal seeding #2, biopsy: Atypical glands 82b33 Fro 4) R/O peritoneal seeding #3, biopsy: No tumor present. Codets Keghist 85Cj3 Fro 5) R/O peritoneal seeding #4. biopsy: No tumor present Sute Yancuw heaoL C25.0 Fro 6) Omental seeding, biopsy: No tumor present in lymph node Fro 7) Pancreatic resection margin. biopsy: Negative 9tJ9/2o/13 DIAGNOSIS: Pancreas, duodenum and common bile duct, pancreatico-duodenectomy: Intraductal tubulopapillary neoplasm, invasive, pancreas head 1) Size of tumor: 6.5x5.0x5.0cm 2) Extent of invasion: invasion to duodenum and ampulla of Vater 5) Blood vessel invasion: absent 6) Lymphatic invasions: present 7) Perineural invasion: present 8) Surgical margins: free (safety margin: 6.5cm from common bile duct margin, 0.1cm from retroperitoneal margin, 3.5cm from duodenum proximal margin. 5.0cm from pancreas resection margin) 9) Lymph node: metastasis in 7 out of 28 lymph nodes. (mesenteric LN: 1/7. pericholedochal LN: 0/2, inferior head LN: 1/2. LN: 0/0, LN #8: 0/6. LN #12: 0/0, LN #13: 1/1, LN #16: 0/5, LN #17: 4/5, omentum: 0/0) 10) Pathologic stage: pT3N1 11) Related slide: 12) Associated findings: Pan IN 3 in remaining pancreatic parenchyma Tissue labeled "R/O liver mass", biopsy:  Mesothelial cell hyperplasia Tissue labeled "R/O peritoneal seeding #2". biopsy: Atypical glands Tissue labeled "R/O peritoneal seeding #1. #3, #4", biopsy: No tumor present Tissue labeled "omental seeding', biopsy: No tumor present UUID:9CF238DA-57D1-4DDF-9ECB-23BC9F887056 Gallbladder, cholecystectomy: Chronic cholecystitis Redacted Soft tissue, omentum, omentectomy: No tumor present W 9l
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diff --git a/output/text/d86a35ca-e339-4cc3-9ca7-860e24020ec4.txt b/output/text/d86a35ca-e339-4cc3-9ca7-860e24020ec4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ed3a200b75c3260097d5d2f90df977d77422d8b6
--- /dev/null
+++ b/output/text/d86a35ca-e339-4cc3-9ca7-860e24020ec4.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:04474C44-102B-4514-BC48-46889ED478A2 TCGA-DD-AACW-01A-PR Redacted CLINICAL DIAGNOSIS: HCC Specimen : HCC Gross Photo : GROSS: Specimen status: Fresh Operation: Laparoscopic segmentectomy (segment 2) Organ: Liver (15.0 x 6.0 x 4.5 cm, 142.5 gm) Lesion: Hepatic mass Size: 2.0 x 1.8 x 1.5 cm Cut surface: Encapsulated, yellowish tan, round and solid with central necrosis Gross type: Multinodular confluent Extent: Confined to the capsule Resection margin: Not involved, grossly (safety margin: 1.2 cm) Remaining parenchyme: Cirrhosis. Representative sections are submitted. ICD 0. 3 arsnom, hepatoselQlar NDS 817|3 Gross photo: Present Sit stie CQa.O Blocks T1-4, mass of liver x 4 S> s/9/y RM, mass with resection margin x 1 A, nontumorous liver parenchyme x 1 MICROSCOPIC: Tumor type: Hepatocellular carcinoma Edmondson-steiner grade The worst differentiation III The major differentiation III Histologic type: Trabecular Cell type: Hepatic clear cell and solid pattern Fatty change: No Cholangiocarcinoma: No. Fibrous capsule formation: Yes. Capsular infiltration: Yes Septum formation: Yes Surgical resection margin invasion: No Serosal invasion: No Portal vein invasion: No Lymphovascular invasion: Yes Bile duct invasion: No Remaining liver parenchyme: Cirrhosis NOT reported. Gross: Peritoneal fluid, smear, negative.
+
+--- Page 2 ---
+Pleural fluid, smear, inflammation Pleural fluid, smear, negative Peritoneal fluid, smear, negative. Pleural fluid, smear, negative Pleural fluid, smear, negative. Pleural fluid, smear, negative. Pleural fluid, smear, negative Stomach, prepylorus, scopic, no pathologic finding. liver,ectomy,hepatocellular carcinoma,cirrhosis. T56000, P10, M81703, M49500 DIAGNOSIS: Liver, lateral segment, left, laparoscopic segmentectomy: Hepatocellular carcinoma Cirrhosis Suggestion : d 1/13/1y
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diff --git a/output/text/d8786482-0edb-44ea-a907-96bb72378907.txt b/output/text/d8786482-0edb-44ea-a907-96bb72378907.txt
new file mode 100644
index 0000000000000000000000000000000000000000..be400f8f8bfefa38e1636a3ec71034ca86c270be
--- /dev/null
+++ b/output/text/d8786482-0edb-44ea-a907-96bb72378907.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Efces8 BREAST TISSUE CHECKLIST Specimen type: Excision of tumor Specimen size: Not specified Tumor site: Breast Tumor size:3.5 x 3.5 x 3.5 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal and lobular carcinoma Histologic grade: Tumor extent: Not specified Lymph nodes: 1/2 positive for metastasis (Axillary 1/2) Extracapsular invasion of the lymph nodes: Not specified Right, lower. Margins: Not specified outer quadrant Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments... None.
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diff --git a/output/text/d8961eb0-f5ca-4ee3-9c52-dc7e9a41f8e8.txt b/output/text/d8961eb0-f5ca-4ee3-9c52-dc7e9a41f8e8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d965808f4f3bbf90b6535eb705eadc6600187a90
--- /dev/null
+++ b/output/text/d8961eb0-f5ca-4ee3-9c52-dc7e9a41f8e8.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID: 20F4DBD9-02FA-4FFD-AEFS-234910D31263 TCGA-AN-A0AL-01A-PR Redacted TSS Patient ID: Case #: DOB ; Sex: Female Ethnicity (Race): Cancer Sample Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma Date of Procurement:. ) Anatomic Site: Left Breast Tumor location: Primary Tissue Specification: Tumor Specinen Matrix: Tissue Specimen Format: OCT Container: block Type of Procurenent: surgery Grade: 2 T Stage: 4 N Stage: 0 M Stage: 0 Treatment: none Treatment Details: n/a.  Normal Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw Matrix: Blood Specimen Format: frozen Container: tube Date of Procurement: 1cs-0-3 tovcnvmu,mf#rnfrj duct,niv5 85ovf3 Sifu: buast. Nos. c50.q lu 10/21 11
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diff --git a/output/text/d8970a50-2bdb-474d-a75f-e372ba9bbe0c.txt b/output/text/d8970a50-2bdb-474d-a75f-e372ba9bbe0c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c6c83695b8c147a8e9cca617f69bf2fb3e3dcd80
--- /dev/null
+++ b/output/text/d8970a50-2bdb-474d-a75f-e372ba9bbe0c.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+ICD -0 - 3 Procedure Date: Carciomnn, mfiltrathy ductal, n0s Procedure Physician: Attending Physician/Copies To: Sih: iresot, NOS C50.9 UUID:58802C83-2AF7-4978-A3F7-A889E0D914A1 Patient hIstory: TCGA-BH-A1FU-01A-PR  Redacted * DATE OF LMP: : DATE OF LAST DELIVERY: PRE-OP DIAGNOSIS: R BREAST CANCER POST-OP DIAGNOSIS: SAME OPERATIVE PROCEDURE: RIGHT MODIFIED RADICAL MASTECTOMY CLINICAL HISTORY: MATERIAL SUBMITTED: RIGHT (MOD) RADICAL MASTECTOMY, PROCUREMENT BY SURGICAL PROCEDURE INTRAOPERATIVE CONSULTATION: FROzen secTioN: Right breast measuring 18.0 by 17.0 by 5.2 cm with 16.0 by 6.3 cm skin and nipple and partial axillary contents. A tan-white irregular mass measuring 1.8 by 1.0 by 1.2 cm is identified 1.3 cm from the deep resection margin. Mass lies in the center of the mass. Fs Diagnosis: Infiltrating duct. FINAL DIAGNOSIS: - MULTIFOCAL INVASIVE DUCTAL CARCINOA, 1.8 BY 1.2 E POOR NUCLEAR GRADE VASCULAR PBRMEATION SEEN  SKIN, NIPPLE AND DEEP MARGINS FREE OF TUMOR - FIVE (5) LYMPH NODES FREE OF TUMOR - HEMORRHAGE AND HEMOSIDRRIN LADEN MACROPHACES CONSISTENT WITE BIOPSY SITES - FIBROCYSTIC CHANGES Nore: within the invasive tumor, the ductal carcinoma ;in-situ component ts about 30t.. SUPPLCMENTREPORT (HER2/NEU) My signature below is attestation that I have reviewed all slides and agree with the findings as noted below. AS PER THE REQUEST OF OF THE IMMUNOSTAINING IS CARRIED OUT ON PREVIOUS NAGKE SURGICALNC C-erbB2 (HER-2/NEU) DILUTION OF DAKO'S POLYCLONAL ANTIBODY A4SS (DIRECTED AGAINST THE INTRACBLLULAR DCOIN OF c-erbB2) WITHOUT BLOCK *A4" (BREAST CANCER) USING A 1:300 ANTIGEN RETRIEVAL. DISTINCT COMPLETE MERMBRANE STAINING IS IDENTIFIED IN 9Ot OF TUMOR CELLS. THEREFORE, C- OrbB2 (HER-2/NEU) IS INTERPRETED AS POSITIVE (SCORE 3+). SIGNED COPY ON FILE PATHOLOGE! SUPPL INTREPOR (ER/PR) My signature bolow is attestation that I have reviowed all slides and agree with the findings as noted below. IMWUNOPEROXIDASE IDENTIFICATION OF ESTROGEN AND PROGESTERONE RECEPTORS IS CARRIED OUT ON SLIDE S M SES "A4". DISTINCT INTRANUCLEAR STAININC IS IDENTIFIED FOCALLY FOR PROGESTERONE RECEPTOR (2Ot) BUT NQT FOR ESTROGEN RECEPTOR. THEREFORE, PROGESTERONE RECEPTOR IS INTERPRETED AS BOR DERLINE AND ESTROGKN RECEPTOR AS NEGATIVE.
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diff --git a/output/text/d89cfeab-8b72-417f-a0b3-3e7198f09725.txt b/output/text/d89cfeab-8b72-417f-a0b3-3e7198f09725.txt
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index 0000000000000000000000000000000000000000..9d61193a14c6895af6703d91dc8986d68104a405
--- /dev/null
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+1cs-0-3 Cavci omn nifiltnnting ductal, nos 85oo/3 Sit: brast, Nos C50.9 1/28/n Pathology Form Specimen Information Collected by: ys Date: Time: Date Time: Preserved by: *w.w*SPECIMENTYPE(#ofsamples provided+* Frozen Paraffin Block Blood/Serum/Plasma Slide Diseased Normal Diseased Normal Diseased Normal Diseased Normal x x Time to LN2 Time to Formalin Time to LN2 10 min min 30! mina Primary Tumor Organ Size Extension of Tumor. Distance to NAT Roreast 1Qx NO 2 x cm cm Lymph Nodes # Examined # Metastasized Location Axilla 7 Distant Metastasis Organ Detailed Location. Size Pathological Staging Stage: SLA pT1 N9 Mo Notes: Redacted UUID:90AF32F0-5684-4D5B-B619-2812DA3823C6 TCGA-C8-A12Q-01A-PR 4 11301
+
+--- Page 2 ---
+Microscopic Description .t.wwHistologicaPatenwrwww.. Structura! Pattern Cell Distribution +  Streaming  Diffuse  Storiform Mosaic + Fibrosis Necrosis  Palisading Lymphocytic Infiltration Cystic Degeneration Vascular Invasion Bleeding Clusterized Myxoid Change  Alveolar Formation  Psammoma/Calcification Indian File y+Cellular Differentiation+ .  Lymphomatous + Sarcomatous +- Adenomatous Squamous Round Cell  Large Cell Glandular cell  Squamoid Cell Small Cell Fibroblast Spindle Cell Cell Stratification  RS Cell/RS Like Osteoblast Secretion  Keratin Inflam. Cell Lipoblast  Desmosome Intracyt. Vacuole  Plasma Cell Myobiast Peari Gland formation ~  Poor Well  Moderate Cellular Differentiation: 1 11 III 0 Nuclear Atypia:  Aniso Nucleosis. Hyperchromatism Nucleolar Prominent  Multinucleated Giant Cell + Mitotic Activity + Nuclear Grade: eHcData Date Value  Result Marker  Negative  Positive ER  Negative   Positive PR  Negative   Positive Her-2/neu  Negative  Positive  B-Celi Marker  Negative   Positive T-Cell Marker  Negative  Positive Other: Negative Positive Other: Final Pathology Report. Tuvwr luctt Creinmq Grade: Histological Diagnosis: Comments: Date Pathologist Principal Investigator
+
+--- Page 3 ---
+COnSOLIDATED DIAgNOsTIC PAThOLOgy fORm* Microscopic Appearance: Histological pattern: CELL DISTRIBUTIONS + STRUCTURAL PATTERN  Diffuse + Y| Streaming Mosaic Storiform Necrosis (Fibrosis Lymphocytic Infiltration Palisading Vascular Invasion Cystic Degeneration  Clusterized X Bleeding Alveolar Formation  Myxoid Change  Indian File Psammoma/Calcification 2. Cellular features: Squamous Adenomatous Sarcomatous Lymphomatous  Squamoid Cell Glandular cell Round Cell Large Cell Spindle Cell Cell Stratification .Fibroblast Small Cell  Keratin Secretion Osteoblast RS Cel/RS Like Intracyt. Vacuole 4 Lipoblast Desmosome Inflam. Cell Gland formation  Myoblast Pear! Plasma Cell Otherwise Specified: D, s 0% Dr st]. 2.Cellular Differentiation: Well Moderaely Poor 3.Nuclear Atypia: Nuckar Appearanced X Aniso Nucleosis N Hyperchromatism Nucleolar Prominentd Multinucleated Giant Cell Mitotic Activity Nuckear Grade NOs& tv LNj Date ) PATHOLOGIST STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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diff --git a/output/text/d8ba8024-7154-4037-b006-d79edefea297.txt b/output/text/d8ba8024-7154-4037-b006-d79edefea297.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d160ca92e2118d3f342d4b67ce82bb89516f288e
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+LARGE INTESTINE TISSUE CHECKLIST Specimen type: Colectomy Specimen size: Not specified Tumor site: Sigmoid colon Tumor size: 5 x 4 x 1 cm Tumor features: None specified Histologic type: Adenocarcinoma Histologic grade: Moderately differentiated Tumor extent: Pericolonic tissues Lymph nodes: 6/6 positive for metastasis (Intraabdominal 6/6) Margins: Not specified. Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None
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diff --git a/output/text/d8ca7864-7074-4c35-a942-778cb4b081b1.txt b/output/text/d8ca7864-7074-4c35-a942-778cb4b081b1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0582b03cbe8428f10bc7ab6f7d6d4e342a74c97d
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+TSS 1D SPECIMENS: Jcs.0-3 A. SENTINEL NODE #1 LEFT AXILLA Cas omu mf 1traHng ductl Nes 8500/3 B. SENTINEL NODE #2 D. SENTINEL NODE #3 E. SUPERIOR MARGIN F. SENTINEL NODE #4 CQcF Site. buast Nos c50.9 2/8 SPECIMEN(S): A. SENTINEL NODE #1 LEFT AXILLA B. SENTINEL NODE #2 C. WLE LEFT BREAST NEEDLE LOCALIZATION UUID:9E2EF2C8-A60D-443D-99B6-205B7053175A D. SENTINEL NODE #3 Redacted E. SUPERIOR MARGIN F. SENTINEL NODE #4 GROSS DESCRIPTION: A. SENTINEL NODE #1 LEFT AXILLA Received fresh is a tan pink lymph node 1.5 x 1.0 x 1.0cm. The specimen is serially sectioned and touch preps are taken. Toto A1. B. SENTiNEL LYMPH NODE #2. LEFT AXILLA Received fresh is a tan pink lymph node 0.3 x 0.2 x 0.2cm. The specimen is serially sectioned and touch preps are taken. Toto B1. C. LEFT BREAST WIDE LOCAL EXCISION NEEDLE LOCALiZATION: Received in fresh state is a specimen labeled with patient's name and identification number as above and specimen labeled as "wide local excision left breast needle localization". The specimen consists of a resected portion of predominantly fatty breast tissue weighing 122 grams and measures 12.0 x 7.5 x 3.0 cm. Attached portion of skin along the anterior aspect measures 5.0 x 2.2 cm. and skin surface grossly shows no identifiable uiceration. . There is a needle localization wire in place and included radiogram of the specimen indicating the area of density. The margins of the specimen are oriented with sutures, one suture and one clip-anterior, two sutures and two clips-lateral, three clips and three sutures-superior. The margins of the specimen are color coded as folows: red-superior, orange- inferior, blue-anterior, green-lateral, yellow-medial and black-posterior. On serial cut sections, along the off mid portion of the specimen is a tan-white firm tumor measuring 1.5 x 1.5 x 1.0 cm. with a slightly stellate irregular borders seen 1.5 cm. from the deep margin, 1.7 cm. from the superior, 2.2 cm. from the anterior, 3.0 cm. from the lateral margin and 3.0 cm. from the medial margin. The main bulk of the specimen shows a predominantly fatty breast tissue with occasional narrow strands of fibrous stroma There is no other identifiable tumor focus. Multiple sections are submitted in cassettes labelled as follows: C1 through C10: full section of the tumor with margins C1- tumor with posterior margin C2 -section adjacent to the tumor C3 -includes sections of the anterior margin C4: includes sections with inferior margin C6: includes sections with superior margin C11-C12: sections that includes medial margin C13: additional sections from medial margin C14-C15: sections includes lateral margin C16: includes sections from the inferior/lateral margin C17-C18: one en block section C19-C20: additional sections from tumor without margins D. SENTINEL NODE #3 Received fresh are two pieces of fatty tissue in aggregate measuring 3 x 3 x 1 cm. One lymph node is identified measuring 0.4 x 0.3 x 0.2 cm. A touch prep is performed and touch prep diagnosis is given. The lymph node is submitted entirely in cassette D1. E. SUPERIOR MRGIN: Received labeled with patient name and designated as *superior margin" consists of a 4.7 x 3.0 x 1.0 cm. and weighing 15 grams segment of breast parenchyma. It is oriented with one suture marking true superior margin. The margin is inked. It is serially sectioned and the cross surface shows multiple focal
+
+--- Page 2 ---
+TSS ID ! white areas alternating with yellow breast parenchyma. No discrete is identified. The specimen is submitted entirely in 8 cassettes: E1-E8: sequentially submitted. F. SENTINEL NODE #4 Received fresh is a piece of fatty tissue measuring 3 x 2 x 0.5 cm. One lymph node is identified measuring 1.2 x 0.3 x 0.3 cm. A touch prep is performed and touch prep diagnosis is given. The lymph node is submitted entirely in cassette F1. DIAGNOSIS: A. SEnTINEL nODE #1, LEft AXILLA: - ONE LYMPH NODE - NEGATIVE FOR TUMOR (0/1). B. SENTINEL NODE #2, LEFT AXILLA: - ONE LYMPH NODE - NEGATIVE FOR TUMOR (0/1). C. LEfT BREAST, NEEDLE LOCALIZATION WIDE LOCAL EXCISION: - INVASIVE DUCTAL CARCINOMA, SBR GRADE 2. - SIZE OF TUMOR: 1.5 x 1.5 x 1.0 CM. - INVOLUTIONAL CHANGE WITH FOCAL CYSTIC APOCRINE CHANGE -MARGINS OF RESECTION -NEGATIVE FOR TUMOR. D. SENTINEL LYMPH NODE #3, LEFT AXILLA: - ONE LYMPH NODE - NEGATIVE FOR TUMOR (0/1). E.. SUPERIOR MARGIN, LEFt BREAST: - PREDOMINANTLY FATTY BREAST TISSUE - NEGATIVE FOR TUMOR. F. SENTINEL LYMPH NODE #4:  - ONE LYMPH NODE - NEGATIVE FOR TUMOR (O/1). SYNOPTIC REPORT - BREAST Specimens Involved SpecimenS: A: SENTINEL NODE #1 LEFT AXILLA B: SENTINEL NODE #2 C: WLE LEFT BREAST NEEDLE LOCALIZATION D: SENTINEL NODE #3 E: SUPERIOR MARGIN F: SENTiNEL NODE #4 Specimen Type: Lumpectomy - for mass Needle Localization: Yes Laterality: Left Invasive Tumor: Present Multifocality: No WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Tumor size: 1.5cm Additional dimensions: 1.5cm x 1cm Tumor Site: Upper outer quadrant Margins: Negative Distance from closest margin:  Distance from closest margin: 1.5 cm Posterior Tubular Score: 2 Nuclear Grade: 2 2 Mitotic Score: 2 Modified Scarff Bloom Richardson Grade: Necrosis: Absent Vascular/Lymphatic Invasion: None identitied. Lobular neoplasia: None Sentinel lymph node only Lymph nodes: Lymph node status: Negative 0/4  Non-neoplastic areas: Involutional changes. DCIS not present
+
+--- Page 3 ---
+TSS ID ER/PR/HER2 Results ER: Positive PR: Positive HER2: Pending Performed on Case: current case- ER-positive (allred score-8);PR-positive-allred score-6) Pathological staging (pTN): pT 1c N 0 SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimens Involved Specimens: C: WLE LEFT BREAST NEEDLE LOCALIZATION Specimen: Surgical Excision Block Number: ER: Positive Allred Score: 8 = Proportion Score 5 + Intensity Score 3 PR: Positive Allred Score: 6 = Proportion Score 4 + Intensity Score 2 COMMENT: The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring range from 0 to 8. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2. METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Immunohistochemistry was performed using the mouse anti-human ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) provided by following the manufacturer s instructions. This. assay was not modified. interpretation of the ER/PR immunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal review of staining performance.. PRE-OPERATIVE DIAGNOSIS: Left Breast Cancer. INTRAOPERATIVE CONSULTATION: TPA/TPB: No carcinoma identified. Diagnosis called to Dr. at ': ,Part A), Part B), by Dr. TPD: Sentinel lymph node number 3 no carcinoma identified called by Dr. related Dr. at TPF: Lymph node left axillary sentinel excision: No carcinoma identified called by Dr. to Dr. at C: Gross margins - negative for tumor by Dr.e ADDENDUM: SYNOPTIC REPORT - BREAST HER-2 RESULTSE Specimen: Surgical Excision. Block Number: Interpretation:  NEGATIVE Intensity: 1+ % Tumor Staining: 8% Fish Ordered: No METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no tonger than 24 hours. Her2 analvsis was performed using the FDA approved Dako HercepTest (TM) test kit. ) using rabbit anti-human HER2. This assay was not modified. External kit-slides.
+
+--- Page 4 ---
+TSS 1D provided by the manufacturer (cell lines with high, low and negative HER2 protein expression) and in- house known HER2 amplified control tissue were evaluated along with the test tissue. Adequate, well. preserved, clear-cut invasive carcinoma was identified for HER2 evaiuation. Interpretation of the HER2 immunohistochemical stain is guided by published results in the medica! literature, information provided by the reagent manufacturer and by internal review of staining performance.. This assay has been validated according to the 2007 joint recommendations and guidelines from. ASCO and CAP and from the NCCN HER2 testing in Breast Cancer Task Force. Department takes full responsibility for this test's performance. Gross Dictation: , M.D., Pathologist, Microscopic/Diagnostic Dictation: , m.v., Pathologist. Gross Dictation: , M.D., Pathologist, Microscopic/Diagnostic Dictation: , M.u., Pathologist Final Review: , M.D., Pathologist, Microscopic/Diagnostic Dictation: , m.u., Patnoiogist, Microscopic/Diagnostic Dictation: , M.D., Pathologist, . Final Review: , M.D., Pathologist, Final: , M.D., Pathologist, Addendum:, M.D., Pathologist, Addendum Final:, M.D., Pathologist
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diff --git a/output/text/d8d27de0-a5f3-4a56-9c57-5d7964857357.txt b/output/text/d8d27de0-a5f3-4a56-9c57-5d7964857357.txt
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index 0000000000000000000000000000000000000000..235aaf9e7310d7cae414bb7449684fc2a34b899b
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+Hlinical Diagnosis & History: Left breast palpable mass biopsy showed inf. ductal carcinoma. Specimens Submitted: 1: SP: Sentinel node left axilla (fs). 2: SP: Left breast lumpectomy 3: SP:  Superior margin, left breast 4: SP: 1 Medial margin, left breast 5 : SP: J Inferior. margin, left breast 6 : SP: Lateral margin, left breast 7: Sp: Posterior pectoral fascia margin, left breast DIAGNOSIS : 1) LYMPH NODE, SENTINEL NODE, LEFT AXILLA; RESECTION: -1 FOUR BENIGN LYMPH NODES (0/4). - ADDITIONAL DEEPER LEVELS AND IMMUNOSTAINS FOR CYTOKERATINS (AB1:AE3) ARE PENDING AND THE RESULTS WILL BE REPORTED IN AN ADDENDUM. 2) BREAST, LEFT; EXCISION: - INVASIVE DUCTAL CARCINOMA, NOS TYPE, HISTOLOGIC GRADE III/III (SLIGHT) OR NO TUBULE FORMATION), NUCLEAR GRADE III/III (MARKED VARIATION IN SIZE AND SHAPE), MEASURING 1.7 CM IN LARGEST DIMENSION MICROSCOPICALLY (GROSSLY THE TUMOR IS MEASURED AT 1.9CM) . - SCANT HIGH GRADE DUCTAL CARCINOMA IN SITU (DCIS) IS ADMIXED WITH INVASIVE UUID: 846851BE-3D24-46F0-A6BE-CEB22C7D0F620 TCGA-A0-A034-01A-PR CARCINOMA. Redacted - NO CALCIFICATIONS ARE IDENTIFIED IN EITHER THE INVASIVE OR IN SITU COMPONENT. - NO VASCULAR INVASION IS NOTED. - FOR SURGICAL MARGIN STATUS PLEASE SEE PARTS 3-7. - THE NON-NEOPLASTIC BREAST TISSUE SHOWS BIOPSY SITE CHANGES. - RESULTS OF SPECIAL STAINS (ER, PR, HER2-NEU) WILL BE REPORTED IN AN) ADDENDUM. 3) BREAST, LEFT SUPERIOR MARGIN; BXCISION: BENIGN BRKAST PARENCHYMA. 1c d-0-3 4) BREAST, LEFT MEDIAL MARGIN; EXCISION: - BENIGN BREAST WITH FIBROADENOMATOUS CHANGES. Srte: hrut, Nos c50.9 h 10j2s|u ** Continued on next page **
+
+--- Page 2 ---
+5) BREAST, LEFT INFERIOR MARGIN; EXCISION:  BENIGN BREAST PARENCHYMA. 6) BREAST, LEFT LATERAL MARGIN; EXCISION: - BENIGN BREAST PARENCHYMA. 7) BREAST, LEFT POSTERIOR PECTORAL FASCIA MARGIN; EXCISION:  BENIGN BREAST PARENCHYMA. - SKELETAL MUSCLE TISSUE. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. *** Report Blectronically Signed Out *** M.D. 1.D. left axillar, and consists of four lymph nodes measuring 1.2 to 1.8 cm in greatest dimension. All lymph nodes are bisected and entirely submitted. Summary of sections: FscA, fscB, fscc, fscd -- lymph node frozen section control 2.) The specimen is received fresh, labeled "Left breast lumpectomy" and consists 0f an unoriented, pravious incised, 3.7 x 2.2 x 1.9 cm, piece of fibrofatty breast tissue. The specimen is entirely inked black. sectioning reveals a previously biopsied, 1.9 x 1.8 x 1.5 cm, firm, smooth  Serial nodular bordered, pink-white mass, iocated 0.2 cm with inked resection margin. The mass is partially surrounded by a 2.5 x 1.8 x 1.2 cm area of mildly dense, focally nodular, pink-white fibrous tissue. 2  breast parenchyma consists of lobules of yellow adipose. A portion of tumor The remaining has previously been submitted to Tps. The remaining specimen is representatively submitted. Summary of sections: MT - tumor and closest tissue edge FFT -- full face of tumor tumor RS -- present in sections of remaining fibrous tissue .A. 3). The specimen is received fresh, labeled "superior margin left breast" and 0.6 cm thick. ~A stitch marks the new margin of excision, which is inked black. The tissue is serially sectioned and entirely submitted. ** Continued on next page **
+
+--- Page 3 ---
+Summary of sections:. ss - sequsntial sections 4). The specimen is received fresh, labeled "medial margin left breast" and consists of a piece of fibrofatty breast tissue measuring 3 x 1.8 cm, and 0.9 cm thick. A stitch marks the new margin of excision, which is inked. black. The tissue is serially sectioned and entirely submitted.. Summary of sections: ss - sequential sections 5). The specimen is received fresh, labeled "inferior margin left breast". and consists of a piece of fibrofatty breast tissue measuring 2.5 x 2.2 cm, and 0.8 cm thick. ~A stitch marks the new margin of excision, which is inked black. The tissue is serially sectioned and entirely submitted.. Summary of sections: ss - sequential sections 6). The specimen is received fresh, labeled "lateral margin left breast" and consists of a piece of fibrofatty breast tissue measuring 3.5 x 3.2 cm, and 1 cm thick. A stitch marks the new margin of excision, which is inked black. The tissue is serially sectioned and entirely submitted. Summary of sections: Ss - sequential sections. 3 7). The specimen is received fresh, labeled "posterior pectoral fascia margin left breast fresh" and consists of a piece of fibrofatty breast tissue measuring 2.6 x 1.6 cm, and 0.7 cm thick. A stitch marks the new margin of excision, which is inked black. The tissue is serially sectioned and entirely submitted. Summary of sections: ss - sequential sections. Summary of Sections: Part 1: SP: Sentinel node left axilla (fs). Block Sect. Site. PCs 1 fscA ** Continued on next page **.
+
+--- Page 4 ---
+1 fscB fscc 1 fscD 2 Part 2: SP: Left breast lumpectomy. Block Sect. site pCs 1 FFT 1 MT 2 RS 4 r 5 Part 3: SP: Superior margin, left breast. Block Sect. Site PCs 4 ss Part 4: SP: Medial margin, left breast. Block Sect. Site PCs ss 8 Part 5: SP: Inferior margin, left breast Block Sect. Site PCs 5 ss Part 6:  Sp: Lateral margin, left breast Block Sect. Site PCs 6 ss 8 Part 7: SP: Posterior pectoral fascia margin. left breast. Block Sect. Site PCs 3 ss 7 Procedures/Addenda: Addendum Date Ordered: Date Complete: Status:  Signed Out Date Reported: By: M.D. Addendum Diagnosis PART #2 LEFT BREAST: Immunohistochemical stains were performed on formalin-fixed tissue with the following results for invasive carcinoms (block 2):. ESTROGEN RECEPTOR 0% nuclear staining PROGESTERONE RECEPTOR 0% nuclear staining HER2 ** Continued on next page **.
+
+--- Page 5 ---
+Negative (0 ) Page 5of6 (0% of invasive tumor cells exhibit complete membranous staining; Uhiformity of staining: absent; Homogeneous, dark circumferential pattern: absent) Comment: Controls are satisfactory. FDA-approved rabbit monoclonal primary antibody (clone 4B5) directed against PATHWAY anti-HER-2/neu is an the internal domain of the c-erbb-2 oncoprotein (Her2) for immunohistochemical detection of HeR2 protein overexpression in breast cancer tissue routinely processed for histologic evaluation. The Her2 test results are reported in accordance with the Asco/cAp guideline reconmendations for HeR2 testing in breast cancer (J clin Oncol 2007; 25(1):118-145). The ER and pR rabbit monoclonal antibodies are also FDA approved. 1. SENTINEL LYMPH NODE(S), LEFT AXILLA (PART 1) Additional H/s stained sections and immunohistochemical stains for cytokeratins (AEl:Ae3) show no evidence of metastatic tumor. Some of the immunohistochemistry and Ish tests --are devaloned snd performance characteristics were determined by They have not been cleared or approved by the us Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA : 88) as qualified to perform high complexity clinical laboratory testing. M.D. S Intraoperative Consultation: Note:  The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS: BENIGN LYMPH NODES SP: SENTINEL NODE LEFT AXILLA (FS): PERMANENT DIAGNOSIS: SAME. D Note:  The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. ** Continued on next page **
+
+--- Page 6 ---
+) FROZEN SECTION DIAGNOSIS:  Page 6 of 6 BENIGN LYMPH NODES SP: SENTINEL NODE LEFT AXILLA (FS) :  PERMANENT DIAGNOSIS: SAME 19.0 ** End of Report
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diff --git a/output/text/d8ed9e75-d33b-42c0-9ae1-eae7bb42e739.txt b/output/text/d8ed9e75-d33b-42c0-9ae1-eae7bb42e739.txt
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index 0000000000000000000000000000000000000000..452d55c69383ef4efa7a2ade8cf234ee6cdd0f12
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+
+--- Page 1 ---
+TCGA # Internal Sample ID Diagnosis: This is an invasive, moderately differentiated adenocarcinoma of the colon, G 2, with permeation of all wall layers, p T 3, with lymphatic vessel invasion, L 1,. otherwise free lymph nodes (0 of 18).. Tumor classification: ICD-O-DA M 8140/3 G 2, p T 3,pN0, L 2. The resection margins were free.. 1cp-0-3 Adnocsrcinona, N0s8140f3 h 9|30f1 Sitx: thonsvhse eton C18.4 UUID:AE846243-5146-48F3-A59B-A9455C72F0F5 TCGA-AA-A020-01A-PR Redacted
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diff --git a/output/text/d9206bc9-2bb9-4b96-9a38-0fdaa864e4d7.txt b/output/text/d9206bc9-2bb9-4b96-9a38-0fdaa864e4d7.txt
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index 0000000000000000000000000000000000000000..315cf1fd15542ac0c2e561f0ec03e18c8d947846
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+
+--- Page 1 ---
+/cs-0-3 Carcinomn, infilfrahng ductal Nos 85oo/3 PHh sife: Brsst,uOq C50.y 119/1 pw CQcF Sih: Bust, Nos c5o.9 Diagnosis: 2. Left excised breast material with a well differentiated invasive ductal breast carcinoma,. max. 2.2 cm in size, without any visible invasion ofthe lymph vessels with a minimum margin of 3 mm at 6 o'clock. Surrounding lipomatous atrophic glandular tissue, no intraductal tumor component. Tumor classification: M-8500/3, G1, pT2, pL0, pSN0 (0/2), pMX, stage II A, R0 UUID:8612388B-3680-4BD8-986C-E7ABE9F92F91 Redacted
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diff --git a/output/text/d92fe16b-422f-48dd-8e85-0eee3707fefd.txt b/output/text/d92fe16b-422f-48dd-8e85-0eee3707fefd.txt
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index 0000000000000000000000000000000000000000..8e665e21259232e5e16abadbd01adbee62dd5a4b
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+JcD-0-3 Caiuiomn, mf!tnutmg duchl, nos 85oo/3 Payh Irt: Busot,L0q e50.5 CQcF Sih: Bust,Nos c5o.9 Diagnosis: Poorly differentiated invasive ductal carcinoma (tumor diameter: 2.2 cm) with focal intraductal components. Concluding tumor classification: NOS, G IlI, pT2N1aL0V0R0 (compare E. no. xxxx) JUID:C4A1A -6AE5-4807-BA05-C73AC0898546 Redacted
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diff --git a/output/text/d94c6686-30cf-4323-a553-48eba7683043.txt b/output/text/d94c6686-30cf-4323-a553-48eba7683043.txt
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index 0000000000000000000000000000000000000000..c071cdecea9e6694055e7aa22c51abe1ffbb6802
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+
+--- Page 1 ---
+UUID:859561F6-3113-45C8-8FBE-718BF860B582 TCgA-LD-A7W6-01A-PR  Redacted Surgical Pathology Report DATe ObTAineD: LOCATION: DATE RECEIVED: SUBMITTING MD: DAtE REpoRTeD: CC: DIAGNOSIS 1. Left breast, PrOphylActIc Simple mastectomy: fOcal AtypIcal Ductal hyperpLaSiA (UPPER INNER QUADRANT, 1 MM, SLIDE 1J), COLUMNAR CELL HYPERPLASIA/CHANGES, COMPLEX SCLEROSING LESION, USUAL DUCTAL HYPERPLASIA, SMALL PAPILLOMATOSIS, SCLEROSING ADENOSIS (WITH ASSOCIATED MICROCALCIFICATIONS) AND APROCRINE METAPLASIA; NEGATIVE FOR MALIGNANCY; NEGATIVE SKIN AND NIPPLE. 2. Right breast, Simple mastectomy: Invasive Lobular CarcinomA. SIZE (INVASIVE): 30 mm LATERALITY: Right TUMOR FOCALITY: Unifocal LESIONAL SITE: Upper inner quadrant extending to the retroareolar area. HISTOLOGIC TYPE: Invasive lobular carcinoma, mixed classical (70%) and pleomorphlc/solid (30%) types NUCLEAR GRADE: I-II of III (classical type); III (pleomorphic type) HISTOLOGIC GRADE: N/A (invasive lobular carcinoma) IN-SITU COMPONENT: LCIS (classical, NG I-II and pleomorphic, NG II-III types) LYMPH NODE SAMPLING: Positive (2/18, largest 23mm; no extranodal involvement) see specimen #3 AJCC CATEGORIES: Stage IIB (assuming "cM0" status) pTNM: pT2 pN1a cTNM: cT2 cN1 cMO INTEGRITY/ORIENTATION: Intact specimen with designated margins. MARGINS (invasive lobular): Negative (> 1 cm) LYMPHOVASCULAR INVASION: : Focal suspicious tor LVI MICROCALCIFICATIONS: Present, assoclated with benign acini. NIPPLE/SKIN: (if applicable) Negative for tumor SKELETAL MUSCLE: Not present Other: Prior biopsy site changes; focal usual ductal hyperplasla, columnar cell changes,. microcysts and apocrine metaplasia. 3. RIght AXILLARy CONteNtS, DISsectiOn: TwO Out Of eighTeeN (2/18) Lymph NODeS POsITivE FOr metastatic breast CarcinomA, LaRgest tumOr 2.3 Cm, with nO extranodaL INVOLVEMENT. ICDO -3 Lobedar rnigsod 8524!3 ***Electronically Signed Out*** W/other type eso,x. COMMENT OyJ i6]o|13 88307X3 Clinical Diagnosis and History: Page 1 of 3
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+Surgical Pathology Report Year old female with right central ILC and + LN, left prophylactic. cT2,cN1,cM0, clinical stage IIB Tissue(s) Submitted: 1: LEFT BREAST MASTECTOMY SUTURE MARKS SHORT SUPERIOR AND LONG LATERAL 2: RIGHT BREAST MASTECTOMY SUTURE MARKS SHORT SUPERIOR LONG LATERAL 3: RIGHT AXILLARY CONTENTS Gross Description: Specimen #1 is received fresh labeled left breast mastectomy suture marks short superior and long lateral and consists of a 719 designating lateral. There is a 13 x 4.5 cm eliptical portion of white skin on the anterior aspect displaying a 1 x 1 x 0.3 cm everted nipple. No skin lesions are appreciated. The posterior margin is intact. The specimen is inked as follows:. Superior-anterior- blue Inferior-anterior- green Posterior- black. The specimen is serially sectioned to reveal two indurated foci within the fibrous tissue, one located retroareolar located approximately 3 cm deep to the nipple. The retroareolar nodule measures approximately 0.6 x 0.6 x 0.4 cm and is 2 cm from the anterior margin and 6.5 cm from the deep margin. Approximately 3 cm lateral to the aforementioned nodule is an additional 0.5 x 0.4 x 0.4 cm ill-defined tan rubbery to indurated nodule located at the junction of the lower outer and upper outer quadrant, 3 cm from the deep margin and 4.5 cm from the nearest anterior inferior margin. The remaining cut surface consists of approximately 75% yellow lobulated adipose tissue and 25% scattered white rubbery micronodular fibrous tissue. Representative sections are submitted as follows: 1A-1B: retroareolar indurated nodule (no margins) 1C: closest anterior and posterior margins to retroareolar nodule. 1D: skin overlying retroareolar nodule 1E: nipple 1F-1G:  lateral nodule (no margins) 1H: posterior and nearest anterior margin to lateral nodule 1: upper outer quadrant 1J: upper inner quadrant 1K: lower outer quadrant 1L: lower outer quadrant. Please note all representative quadrant sections contain no margins.. Time in formalin: submitted same day. Specimen #2 is received fresh labeled right breast mastectomy suture marks short superior long lateral and consists of an 833 gram, 23 x 18 x 4 cm right total mastectomy specimen with two attached sutures, short designating superior and the long designating lateral. There is an 11.5 x 4.2 cm white elliptical portion of skin on the anterior aspect, which displays a 1 x 1 x 0.5 cm everted nipple. There is a 0.5 x 0.3 x 0.2 cm raised tan-white nodule located on the skin at 4 o'clock, 0.8 cm from the 4 o'clock margin. The posterior margin is intact. The specimen is inked as follows:. Superior-anterior- blue Inferior-anterior- green Posterior- black. The specimen is serially sectioned to reveal a 3 x 2.8 x 2.0 cm ill-detined markedly indurated tan-white irregular mass located predominantly in the upper inner quadrant and extending retroareolar. The mass is located 4 cm from the distal margin and 2.2 cm from the overlying skin. The specimen is radiographed and two clips are identified located in contiguous slices. Palpably the two clips are present within the same mass. The mass is located within 1.1 cm of the nearest anterior margin. The remaining breast parenchyma consists ot approximately 75% yellow lobulated adipose tissue and 25% scattered white rubbery nodular fibrous tissue. No additional masses are identified. Representative sections are submitted as follows:. 2A-2D: representative sections of mass, one section per contiguous slices to include both areas surrounding clips 2E: representative deep margin and mass 2F-2G:   mass to nearest anterior margin 2H:  nipple and skin nodule to closest margin (green 4 o'clock margin). 2l: upper outer quadrant 2J: lower outer quadrant Page 2 ot 3
+
+--- Page 3 ---
+Surgical Pathology Report 2K: lower inner quadrant 2L: upper inner quadrant. Time in formalin: submitted same day Specimen #3 is received in formalin labeled right axillary content and consists of a 10 x 7 x 3 cm aggregate of fat in which multiple Iymph nodes are identified ranging from 0.1 cm to 2.3 cm in greatest dimension. Some ot the larger lymph nodes are sectioned to reveal white and focally firm cut surfaces possibly consistent with tumor. The lymph nodes are submitted in its entirety with the exception of the largest grossly polypoid lymph node as follows: 3A: tive lymph nodes 38:  six lymph nodes 3C-3G:  each cassette contains one lymph node bisected 3H-3J:  one lymph node trisected 3K: representative section of largest grossly positive lymph node. 3L: one lymph node bisected. 23413 Page 3 of 3 END OF REPORT
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diff --git a/output/text/d96116c2-da3b-4c32-a339-a49c3cad0372.txt b/output/text/d96116c2-da3b-4c32-a339-a49c3cad0372.txt
new file mode 100644
index 0000000000000000000000000000000000000000..58e2095c3945f3f0229e35120784bfd5aacff2fa
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SPECIMENS: A. LEFT KIDNEY SPECIMEN(S): A. LEFT KIDNEY GROSS DESCRIPTION: A. LEFT KIDNEY, NEPHRECTOMY: Received fresh state a specimen labelled with patient's name and identification number as above,and Iabelled "LEFT KIDNEY ,Specimen consist of a left radical nephrectomy specimen comprised of left kidney with abundant perinephric fat , attached ureter and left adrenal gland with a combined weight of 1400 grams. The specimen measures 21 x 13 x 11.5 cm. The attached ureter measures 3 cm. in length and 1 cm. in diameter. Adrenal gland measures 3 x 2.5 x 1.5 cm. grossly is not remarkable. Mucosa of ureter,and hilar blood vessels are not remarkable. .The specimen when bisected,located along the upper pole is a 2.5 x 2.5 x 1.8 cm. solid mass with creamy yellowish cut surface .Grossly the tumor appears confined within kidney parenchyma. The cortex shows distorsion by various size cyst and marked fatty infiltration of medullary area.Cysts ranging in size from 0.2cm to 2.5 cm. Some cysts display golden-yellow discoloration around the gray-tan lining. .The parirenal fat is difficult to separate from the renal capsule. Multiple section are submitted in cassttes labelled as follows: A1: ureteral and vascular margins A2-A6: sections from tumor in toto A7-A13: sections from cyst A14: sections from adrenal gland A15-A16: presumptive lymph nodes DIAGNOSIS: A. LEFT KIDNEY, NEPHRECTOMY: - PAPILLARY RENAL CELL CARCINOMA, FUHRMAN GRADE 2 OF LEFT KIDNEY. SIZE OF TUMOR - 2.5 X 2.5 X 1.8 CM. - CHRONIC INTERSTITIAL PYELONEPHRITIS WITH PROMINENT CYSTIC CHANGES.. - LEFT ADRENAL GLAND - NO SPECIFIC PATHOLOGIC CHANGE -  NEGATIVE FOR TUMOR. - URETERAL AND HILAR VASCULAR MARGINS- NEGATIVE FOR TUMOR. SYNOPTIC REPORT - KIDNEY (PARTIAL OR RADICAL) Specimens Involved Specimens: A: LEFT KIDNEY Specimen Type: Radical nephrectomy With adrenal gland Laterality: Left Tumor Site: Upper pole Focality: Unifocal Tumor Size (largest tumor if multiple): Greatest dimension: 2.5cm Additional dimensions: 2.5cm x 1.8cm Macroscopic Extent of Tumor: Tumor limited to kidney WHO CLASSIFICATION Papillary renal cell carcinoma 8260/3. Histologic Grade (Fuhrman Nuclear Grade): G2: Nuclei slightly irregular, approximately 15 u; nucleoli evident  Invasion of Vascular/Lymphatic: Absent Perinephric Tissue Invasion:  Absent Margins: Margins uninvolved by invasive carcinoma Adrenal Gland: Uninvolved by tumor Regional Lymph Nodes: Negative 0 / 2 Additional Findings: Interstitial disease type::  chronic interstitial pyelonephritis cystic changes
+
+--- Page 2 ---
+Pathological Staging (pTNM):  pT 1a N 0 M x CLINICAL HISTORY: None given PRE-OPERATIVE DIAGNOSIS:E Left renal mass.
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diff --git a/output/text/d9a4426d-b0c1-4649-86a8-b7faadb1ff24.txt b/output/text/d9a4426d-b0c1-4649-86a8-b7faadb1ff24.txt
new file mode 100644
index 0000000000000000000000000000000000000000..041c492550a15f9012932e182c5da843c76a478a
--- /dev/null
+++ b/output/text/d9a4426d-b0c1-4649-86a8-b7faadb1ff24.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:11FB2902-12C0-4F01-ADF1-172E8736B378 TCGA-3U-A98E-01A-PR Redacted Sampie #. TcD o3 Gender:  Fema le DOB: Race: white 9s5zl3 maQgranj Report Date: Tissue Procurement Date: Q38.4 Surgical Pathology Report FINAL PATHOLOGIC DIAGNOSIS 12114 A. Aortic adventitia; excision:  Infiltrating malignant mesothelioma B. Lymph node, AP window; excision:  Metastatic malignant mesothelioma in two of six 1ymph nodes (2/6) C. Pericardial cyst; excision: - Pericardial cyst Deposit of malignant mesothelioma (4 mm) in pericardial fat D. Lymph node, #7; excision:  One lymph node, no tumor (0/1) E. pleura, left; pleurectomy: - Epithelioid malignant mesothelioma, see parameters below Thoracic Mesothelioma pathologic Parameters pleura/Pericardium, Resection MACROSCOPIC Specimen Type: Pleural resection. Tumor site:' Left pleura and pericardium Tumor Configuration and size: Diffuse, with two dominant nodules, larger 9.5 x 5.5 cm and second 4.0 x 3.5 cm MICROSCOPIC Histologic Type: Epithelioid (epithelial) mesothelioma, tubulopapillary and deciduoid types Tumor Extension: Into mediastinal fat Into pericardial fat Mediastinal organ: Aortic adventitia venous/Lymphatic Invasion: Indeterminate Margins:' Cannot be assessed *pathologic Staging (pTnm): pT4, N2, MX Primary Tumor (pT) pt4: Tumor'(locally advanced technically unresectable) involves any of the ipsilateral pleural surfaces, with at least 1of the following: diffuse or multifocal invasion of soft tissues of the chest wall, any involvement of rib, invasion through the diaphragm to the peritoneum, invasion of any mediastinal organ(s), direct extension to the contralateral pleura, invasion into the spine, extension to the internal surface of the pericardium, pericardial effusion with positive cytology, invasion of the myocardium. Regional Lymph Nodes (pN) pn2: Metastases in the subcarinal 1ymph node(s) and/or the ipsilatera7 interna7 mammary or mediastinal lymph node(s) Specify: Number examined: 7 Number involved: 2 Distant metastasis (pm): pmx: Cannot be assessed *effective January 1, 2010 this Checklist utilizes the 7th edition TNM staging system for pleural mesothelioma of the American Joint Committee on Cancer (Ajcc) and the International Union Against Cancer (uicc). xxx Page 1
+
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+[] m.d. Interpretation performed by the Attending Pathologist and reviewed with the Resident/fellow, [], M.D. Electronically signed Out by [] M.D. clinical history: The patient is a year old female with mesothelioma who undergoes left thoracotomy. Specimens Received: A: Aortic adven tissue B: AP window node c: Pericardium cyst; removal D: #7 1ymph node E: Left pluera Gross Description: Received are five containers, each labeled with the patient's name and medical record number. A. Container A is further designated "1. Aortic adven tissue." Received fresh for frozen section diagnosis is a 1.2 x 1.0 x 0.3 cm pink-tan, rubbery tissue that is entirely frozen. Frozen section diagnosis is "positive for infiltrating mesothelioma" by Dr. []. The frozen section remnant is submitted entirely in cassette Alfs. Container B is further designated "2. AP window node." Received fresh and placed in formalin are four tan-brown, rubbery fragments of tissue ranging in measurement from 1.9 to 0.4 cm. The largest lymph node is bisected to revea1 a homogeneous pale, white, cut surface. The specimen is submitted as follows: B1: largest lymph node bisected b2 : four candidate lymph nodes b3: two candidate 1ymph nodes B4: remaining soft tissue Container c is further designated "3. Pericardium cyst; removal." Received fresh and placed in formalin is a pink-tan cystic mass measuring 4 x 2 x 1.5 cm. The outer surface is pink and translucent with a mild amount of adipose tissue. The wall is thin and is sectioned open to reveal approximately 5 cc' of clear to light, yellow fluid. There are no masses or lesions along the cyst wall and  it appears' to be simple unilocular cyst. The specimen is entirely submitted in cassettes c1-c3. placed in formalin is a 1.8 x 1.0 x 0.5 cm pink-tan lymph node. It is bisected to reveal a brown-tan, heterogenous cut surface and the specimen is submitted in cassette D1. E. Container E is further designated "5. Left pluera." Received fresh and placed in formalin is a 150.9 gram, 12.5 x 11.8'x 2.5 cm aggregate of pleura. The specimen arrived in multiple pieces and comes unoriented. The majority of the specimen has thin, pink-tan, translucent pleura but there are areas of tan-white thickening. The largest nodular area measures 9.5 x 5.5 x 3 cm. The volume of the specimen is 250~cc. A second fragment contains a 4 x 2 x 3.5 cm white-tan, firm' to rubbery nodule. It is serially sectioned to reveal a fairly homogeneous tan-white-pink, cut surface. Sectioning of the larger nodule reveals a tan-white to focally yellow cut surface. The tumor in most areas appears delineated from the surrounding muscle and soft tissue but in other areas appears to be within the muscle. The specimen is submitted as follows: E1-e8: multiple sections of largest nodule with surrounding soft tissue Page 2
+
+--- Page 3 ---
+muitiple sections of the smaller nodule E13-e15: additional representative sections of the larger nodule XX [] m.d. Intraoperative Consult Diagnosis:. A1FS. "positive for infiltrating mesothelioma" by Dr. [].. 181Y Page 3 X  Bastd Ce) J2/2
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diff --git a/output/text/d9b78b9b-fba0-4798-82eb-30d9b1013845.txt b/output/text/d9b78b9b-fba0-4798-82eb-30d9b1013845.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1b06e67dd68965ef3d6d2769f3dd8456ac60b6e6
--- /dev/null
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+
+--- Page 1 ---
+/cD-0-3 Cmcima, mifiltratng ductal, Nos85os/3 Sith: Brsst, Nos c50.9 Diagnosis: Poorly differentiated inyasive ductal carcinoma with focal intraductal spread (maximum microscopic tumor diameter: 1.5 cm; distance from nearest resection margin less than 0.1 cm) with multiple ulcerations of the skin. Diagnosis: 1. Ablated breast sample with a further focus of poorly differentiated invasive ductal carcinoma (tumor diameter: 1.5 cm; distance from dorsal margin 0.8 cm and from nearest lateral resection margin 1 cm, other margins remain free). Concluding tumor classification: NOS, G III, pT1c(m)pN0(0/13)L0V0R0. UUID: EB9B8904-F6CC-451F-8628-50CC71F1F7C3 Redacted
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diff --git a/output/text/d9bbb1ef-af2d-420b-b4f3-f4fadfd2e4cd.txt b/output/text/d9bbb1ef-af2d-420b-b4f3-f4fadfd2e4cd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..de28184a8351dcfba4cb79a1fb4eb46055636463
--- /dev/null
+++ b/output/text/d9bbb1ef-af2d-420b-b4f3-f4fadfd2e4cd.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+DIAGNOSIS: 1. Tumor #1, right kidney (resection): Renal cell carcinoma, clear cell type, Fuhrman nuclear grade II 2. Tumor #2, right kidney (resection): Renal cell carcinoma, clear cell type, Fuhrman nuclear grade II 3. Tumor #3, right kidney (resection): Renal cyst 4. Tumor #4, right kidney (resection): Renal cell carcinoma, clear cell type, Fuhrman nuclear grade II 5. Tumor #5, right kidney (resection): Renal cell carcinoma, clear cell type, Fuhrman nuclear grade II 6. Tumor #6, right kidney (resection): Renal cell carcinoma, clear cell type, Fuhrman nuclear grade II 7. Rib, 11th, right (resection): Gross examination only NOTE: CLINICAL INFORMATION: Allocate Order to Protocol: Brief Clinical History: VHL with multiple tumors in right kidney. Specimen Taken For Protocol: Yes Patient Identification Page 1 of 3
+
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+PROcEDuRE: Pre-Operative Diagnosis: multiple tumors in right kidney. Post-Operative Diagnosis: same Operative Findings: 6 tumors removed from right kidney.. SpECIMENS SUBMITTED: 1. TUmOR, # 1 2. TUMOR. # 2 3. TUMOR, # 3 4. TUMOR, # 4 5. TUMOR, # 5 6. TUMOR, # 5 7. RIB. 11th rib GROss DEscRIpTioN: Received are 7 formalin-filled containers labeled with the patient's name, medical record number. and further described as follows: 1. "Tumor #1" are two yellow/brown tissue fragments, each measuring 0.5 x 0.5 x 0.5 cm. Both specimens are wrapped in lens paper and entirely submitted in a white cassette labeled for permanent processing. 2. "Tumor #2" is a yellow/brown piece of tissue measuring 0.8 x 0.8 x 0.8 cm. 50% is procured for Research. In Surgical Pathology, the remainder of the specimen is received and is consistent with the above description. The specimen is placed in a filter bag and placed in a white cassette labeled #2 for permanent processing. 3. "Tumor #3" is a white/tan/red piece of tissue measuring 1 cm in diameter consistent with a cyst wall". The. specimen is serially sectioned and entirely submitted in a white cassette labeled. #3 for permanent processing. 4. "Tumor #4" is a brown and yellow piece of tissue measuring 2 x 1.5 x 1.2 cm. 50% is procured for Research. The specimen is received in Surgical Pathology and is consistent with the above description. The specimen is serially sectioned and entirely submitted in a white cassette labeled. . #4 for permanent processing. 5. "Tumor #5" is a tan/brown/yellow piece of tissue 3.2 x 3.0 x 3.0 cm. 85% is procured for Research. The specimen is received in Surgical Pathology and is consistent with the above description. The specimen is serially sectioned and entirely submitted in a white cassette. A-B for permanent processing. 6. "Tumor #6" is a tan/brown piece of tissue measuring 2.8 x 2.2 x 2.1 cm. The specimen is sectioned revealing a mostly homogeneous surface with slightly hemorrhagic areas. 85% of the specimen is procured for Research. The specimen is received Surgical Pathology and is consistent with the above description. The specimen is. serially sectioned and entirely submitted in a white cassettes labeled. ?-B for permanent processing. Patient Identification. Page 2 of 3
+
+--- Page 3 ---
+7. "Rib, 11th" is a white/tan 3.0 x 2.0 x0.8 cm piece of rib with some adherent tan soft tissue. No mass lesions are identified. The specimen is kept for gross examination only.. No consultants Patient Identification Page 3 of 3
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diff --git a/output/text/d9dd61ae-349c-4d5e-a306-8f771028429a.txt b/output/text/d9dd61ae-349c-4d5e-a306-8f771028429a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..db05e45fe2c41942cd07808ff225256819172a3e
--- /dev/null
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@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UUID:4FC32F17-7A4D-4FF6-A710-FFFBC610CB56 TCGA-EW-A6S9-01A-PR Redacted Surgical Pathology Report Name: xx Case #: x DOB: Collected: Gender: F Received: x MRN: xx Reported: X Location: x Physician: x Pathologic Interpretation: IcD-O-3 A. SENTINEL NODE #1 Carcnona, urjistratiry METASTATIC CARCINOMA to one lymph node (1/1). 0 8s00f3 duct-NOS Largest tumoral deposit is 1mm. QtCF Stx NOTE: Metastatic deposit is not identified in frozen section slide. RBreo+NoS C50.9 B. SENTINEL NODE #2 Negative for carcinoma, one lymph node (0/1). R Brorst, uypur-suter C. SENTINEL NODE #3 C60.4 Qiooliof Negative for carcinoma, one lymph node (0/1).. 9 7j24J> 3 D. RIGHT BREAST MASS: INVASIVE DUCTAL CARCINOMA, poorly differentiated, Nottingham grade 2 (3+2+2=7), 2.0 cm. Surgical resection margins are negative for invasive carcinoma; the closest one is the anterior at 6mm. DUCTAL CARCINOMA IN SITU, intermediate grade, solid and cribriform type with necrosis and retrolobular involvement present in five out of 15 slides examined.. Surgical resection margins are negative for in situ carcinoma; the closest one is the anterior at 10 mm. Lymphovascular invasion is identified.. INVASIVE CARCINOMA OF THE BREAST: Complete Excision (Less Than Total Mastectomy, Including Specimens Designated Biopsy, Lumpectomy, Quadrantectomy, and Partial Mastectomy With or Without Axillary Contents) and Mastectomy (Total, With or Without Axillary Contents; Modified Radical; Radical). Procedure Excision without wire-guided localization Lymph Node Sampling Sentinel lymph node(s) Specimen Laterality Right
+
+--- Page 2 ---
+Tumor Site: Invasive Carcinoma Upper outer quadrant Histologic Type of Invasive Carcinoma Invasive ductal carcinoma (no special type or not otherwise specified) Tumor Size: Size of Largest Invasive Carcinoma Greatest dimension of largest focus of invasion >1 mm: 20 mm. Additional dimensions: 15.0 x 10.0 mm Histologic Grade: Nottingham Histologic Score Glandular (Acinar)/Tubular Differentiation  Score 3: <10% of tumor area forming glandular/tubular structures Nuclear Pleomorphism  Score 2: Cells larger than normal with open vesicular nuclei, visible nucleoli, and moderate variability in both size and shape Mitotic Rate Score 2 (4-7 mitoses per mm?) Overall Grade Grade 2: scores of 7 Tumor Focality Single focus of invasive carcinoma Ductal Carcinoma In Situ (DCIS) DCIS is present Size (Extent) of DCIS Present in five out 15 slides examined Architectural Patterns (select all that apply) Cribriform Nuclear Grade (see Table 2) Grade II (intermediate) Necrosis Present, focal (small foci or single cell necrosis) Lobular Carcinoma In Situ (LCIS) Not identified Margins Invasive Carcinoma Margins uninvolved by invasive carcinoma Distance from closest margin: 6 mm Specify margin: Anterior DCIS Margins uninvolved by DCIS Distance from closest margin: 10 mm + Specify margin: Anterior
+
+--- Page 3 ---
+Lymph Nodes Number of sentinel tymph nodes examined: 3 Total number of lymph nodes examined (sentinel and nonsentinel): 3 Number of lymph nodes with macrometastases (>2 mm): 0 Number of lymph nodes with micrometastases (>0.2 mm to 2 mm and/or >200 cells): 1 Number of lymph nodes without tumor cells identified: 2 Extranodal Extension Not identified Method of Evaluation of Sentinel Lymph Nodes Hematoxylin and eosin (H&E), 1 level Immunohistochemistry pending Lymph-Vascular Invasion Not identified Pathologic Staging (based on information available to the pathologist) (pTNM) Primary Tumor (Invasive Carcinoma) (pT) pT1c: Tumor >10 mm but 20 mm in greatest dimension Regional Lymph Nodes (pN) Modifier (sn): Only sentinel node(s) evaluated. Category (pN) pN1mi: Micrometastases (greater than 0.2 mm and/or more than 200 cells, but none greater than 2.0 mm). Distant Metastasis (pM) Not applicable Ancillary Studies  Performed on another specimen Specify specimen (accession number): xx Estrogen Receptor (ER) Results and interpretation: Positive Immunoreactive tumor cells present Quantitation: 50% Progesterone Receptor (PgR) Results and interpretation: Positive Immunoreactive tumor cells present Quantitation: 50% HER2 (results for invasive carcinoma performed on this specimen or a prior core needle biopsy or incisional biopsy) Immunoperoxidase Studies Results: Positive (Score 3+) Preliminary AJCC Classification (7th Edition): pT1c pN1mi pMn/a (Final classification pending evaluation of keratin immunostain on sentinel nodes) Procedures/Addenda: Addendum Date Ordered: Status: Date Complete: Date Reported: Addendum Diagnosis
+
+--- Page 4 ---
+Parts B-C: Immunohistochemistry for keratin is negative. Final AJCC Classification: pT1c pN1mi pMn/a Intraoperative Consultation:. A. SENTINEL NODE #1( ), FS: Negative lymph node. B. SENTINEL NODE #2 ( ), FS: Negative lymph node. C. SENTINEL NODE #3( ), FS: Negative lymph node Reported to OR at. XX, MD Clinical History:. Not provided Operation Performed: Right breast lumpectomy with sentinel node biopsy Pre Operative Diagnosis:. Right breast carcinoma Specimen(s) Received/Processing Information: Fee Codes: A: A: SENTINEL NODE #1 (), FSFrozen section x 1, FS Perm x 1 B: C: B: SENTINEL NODE #2 ( ), FS Frozen section x 1, FS Perm x 1, Cytokeratin Cocktail (KER) x 1 D: C: SENTINEL NODE #3 ( ), Fs Frozen section x 1, FS Perm x 1, FSDeep 1 x 1, Cytokeratin Cocktail (KER) x 1 D: RIGHT BREAST MASS (1 STITCH SUPERIOR, 2 STITCHES LATERAL, 3 STITCHES DEEP)H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E Gross Description: A. Specimen is received fresh and labeled "Sentinel node #1 ( ), FSr. The specimen consists of one lymph node measuring 1.6 x 0.9 x 0.4cm. Specimen is bisected and submitted in toto for frozen section. B. Specimen is received fresh and labeled "Sentinel node #2 (), FS". The specimen consists of one lymph. node measuring 1.3 x 0.9 x 0.3 cm. Specimen is bisected and submitted in toto for frozen section.. C. Specimen is received fresh and labeled "Sentinel node #3 (), FS". The specimen consists of one lymph. node measuring 1.1 x 0.6 x 0.3 cm. Specimen is bisected and submitted in toto for frozen section..
+
+--- Page 5 ---
+D. Specimen is received in formalin and labeled "Right breast mass (1 stitch superior, 2 stitches lateral, 3 stitches deep". The specimen consists of an 8.0 x 8.0 x 4.0 cm lumpectomy specimen, oriented with one stitch at superior, two stitches as lateral and three stitches as deep. The specimen is inked for evaluation of margins: Posterior black. Anterior yellow.  Superior blue Inferior green Lateral orange Medial red Serial sections are white-gray, ill-defined and frm. A mass is identified measuring 2.0 x 1.5 x 1.0 cm; the mass is 1.0 cm from the superior margin, 2.0 cm from the inferior margin, 1.0 cm from the anterior margin, 3.0 cm from the lateral margin, 1.5 cm from the medial margin and 1.0 cm from the deep margin. The remainder of the specimen consists of yellow-white adipose tissue. No other lesions are identified. 90% of. the mass was submitted for microscopic examination. Representative sections are submitted as follows: Cassette #1  Superior margin perpendicular Cassette #2 Inferior margin perpendicular Cassette #3 Lateral margin perpendicular Cassette #4  Medial margin perpendicular Cassette #5 Anterior margin perpendicular Cassette #6 Deep margin perpendicular Cassettes #7-10  Mass and breast tissue adjacent Cassettes #11-15 Other areas w 10
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diff --git a/output/text/d9f4983c-9b83-4ada-ac7d-56e40ee53d5b.txt b/output/text/d9f4983c-9b83-4ada-ac7d-56e40ee53d5b.txt
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index 0000000000000000000000000000000000000000..9873614ac97e7ec9fff1f235b42d9d43a144b2f3
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+
+--- Page 1 ---
+ADDENDUM DISCUSSION: The calculated MIB-1 labeling index is 12.5% ADDENDUM DIAGNOSIS 1-6. TEMPORAL LOBE TUMOR, INCLUDING AMYGDALA, ANTERIOR AND POSTERIOR TEMPORAL LOBE, UNCUS AND HIPPOCAMPUS: ANAPLASTIC OLIGODENDROGLIOMA (WHO GRADE III) IN PREDOMINANT BACKGROUND OF LOW GRADE (GRADE II) OLIGODENDROGLIOMA. MIB-1 LABELING INDEX = 12.5% MICROSCOPIC DESCRIPTION: 1-3, 5-6. Sections demonstrate cortical gray and white matter, including hippocampus. They demonstrate a variably cellular and infiltrating diffuse glioma that is characterized by round nuclei with perinuclear halos or a microgemistocytic phenotype. In the majority of the specimen, the. microgemistocytic phenotype predominates and in large areas is the only pattern seen. Atypia is mild to focally moderate with a few highly atypical nuclei seen. Mitoses are rare in these sections and microvascular proliferation and necrosis are not present.. 4. Sections of the tissue designated as enhancing uncus demonstrate consistent marked hypercellularity. The atypia is greater than that seen in the other regions. In contrast to the presence of only rare mitotic figures in the other regions, scattered mitoses are readily identified. Up to six are seen per 10 high power fields. Microvascular proliferation is also noted. There is no. tumor necrosis.
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diff --git a/output/text/d9fa62da-cde8-4b63-88fd-dd7ef57e2055.txt b/output/text/d9fa62da-cde8-4b63-88fd-dd7ef57e2055.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7ae51ae709cf20c390aac1b9dc9a64a1d471826f
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+--- Page 1 ---
+PAGE 1 PATIEN AGE/SEX: IM REG DR: Received: Collected: Copies tr  UUID:C7D3F5D3-B898-40F0-84D1-AA0BF36A009A TCGA-IQ-A613-01A-PR Redacted SPECIMEN ID: A. TONGUE - MIDDORSAL TONGUE MARGIN FS, B. TONGUE - POSTERIOR DORSAL TONGUE MARGIN FS, C. TONGUE - ANTERIOR DORSAL TONGUE MARGIN FS, TONGUE - POSTERIOR VENTRAL TONGUE MARGIN  FS, D. E.  MOUTH - POSTERIOR FLOOR OF MOUTH MARGIN Es, F. MOUTH ~ ANTERIOR FLOOR OF MOUTH MARGIN  FS, G. TONGUE - ANTERIOR VENTRAL TONGUE. MARGIN FS, H. TONGUE - ANTERIOR DEEP TONGUE MARGIN FS, I. TONGUE - POSTERIOR DEEP TONGUE MARGIN es J. NERVE - LINGUAL NERVE MARGIN FS, K. GLAND, NOS - LEFT SUBLINGUAL GLAND, LYMPH NODE - LEFT NECK LEVELS 2,3,4, L. N. LYMPH NODE - LEFT NECK LEVEL 1 B, O. LYMPH NODE - LEFT NECK LEVEL 1A, P.  VEIN - LEFT EXTERNAL JUGULAR VEIN NODE, Q. VEIN - FATTY TISSUE ON LEFT FACIAL VEIN A. MID DORSAL TONGUE MARGIN: No malignancy seen. B.  POSTERIOR DORSAL TONGUE MARGIN:S No malignancy seen. C. ANTERIOR DORSAL TONGUE MARGIN:S No malignancy seen. D. POSTERIOR VENTRAL TONGUE MARGIN: This report is privileged, confidential and exempt from disclosu ure under applicable law. If you receive this repoxt inadvertently, please call. and return the report to us by mail.. ted o-3 8071/3 CsQ.9 Q 6/4/3
+
+--- Page 2 ---
+PAGE 2 (Continued) FINAL DIAGNOSIS # # # (Continued) No malignancy seen. E. POSTERIOR FLOOR OF MOUTH MARGIN: No malignancy seen.. ANTERIOR FLOOR OF MOUTH MARGIN: No malignancy seen. G. ANTERIOR VENTRAL TONGUE MARGIN: No malignancy seen.. H.  ANTERIOR DEEP TONGUE MARGIN: No malignancy seen. I. POSTERIOR DEEP TONGUE MARGIN: No malignancy seen. J. LINGUAL NERVE MARGIN: No malignancy seen. K. LEFT SUBLINGUAL GLAND: Salivary gland, no malignancy seen. L. LEFT NECK LEVELS 2,3,4: METASTATIC SQUAMOUs CELL CARCINOMA, 0.2 cm, to one out of sixty-three lymph nodes (1/63). M.  LEFT GLOSSECTOMY SUTURE ANTERIOR SUPERIOR: INVASIVE WELL-DIFFERENTIATED KERATINIZING SQUAMOUS CELL CARCINOMA, 3.6 Cm. This report is privileged, confidential and exempt from disclc under le law. If you receive this report inadvertently, please call return the report to us by mail.
+
+--- Page 3 ---
+PAGE 3 (Continued) FINAL DIAGNOSIS *** (Continued) Surgical resection margins are free of tumor.. Perineural invasion is identified. See Tumor Summary. LEFT NECK LEVEL 1: No malignancy seen in four lymph nodes (0/4).. Unremarkable salivary gland. O. LEFT NECK LEVEL 1A: METASTATIC sQUAMOUS CELL CARCINOMA, 0.5 cm, to one out of three lymph nodes (1/3). e. LEFT EXTERNAL JUGULAR VEIN NODE: No malignancy seen in two lymph nodes (0/2).. FATTY TISSUE ON LEFT FACIAL VEIN: Q. No malignancy seen in one lymph node (0/1).. Surgical Pathology Cancer Case Summary Specimen: Lateral border of tongue. Dorsal surface of tongue. Received: In formalin Procedure:  Resection Glossectomy (partial) Specimen Integrity: Intact Specimen Size: Greatest dimension: 5 x 3.5 x 1.9 cm Specimen Laterality: Left Tumor Site: Lateral border of tongue. This report is privileged, confidential and exempt from disclosure under applicable law. If you receive this report inadvertently, please call. return the report to us by mail.
+
+--- Page 4 ---
+PAGE 4 (Continued) * FINAL DIAGNOSIS (Continued) Dorsal surface of tongue Tumor Focality:  Single focus Tumor  Size: Greatest dimension: 2.6 cm Tumor Thickness (pT1 and pT2 tumors): Tumor thickness: 16 mm Tumor Description: Endophytic Ulcerated Histologic Type: Squamous cell carcinoma, conventional Histologic Grade: Gl: Well differentiated Margins: Margins uninvolved by invasive carcinoma Lymph-Vascular Invasion: Not identified Perineural Invasion:  Present Lymph Nodes, Extranodal Extension: Not identified Pathologic Staging (pTnM) : Primary Tumor (pT): pT2: Tumor more than 2 cm but not more than 4 cm in greatest dimension Regional Lymph Nodes (pN): pN2b: Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension Number of Lymph Nodes Examined: 73 Number of Lymph Nodes Involved: Size (greatest dimension) of the largest positive lymph node deposit: 0.5 cm Distant Metastasis (pM): Not applicable If you receive this report inadvertontly, please call return the report to us by mail.
+
+--- Page 5 ---
+PAGE5 (Continued) CLINICAL HISTORY- PRE-OP DX:Not provided  Left neck dissection RELEVANT CLINICAL HX: Not prOVided GROSS DESCRIPTION: A. Received fresh and labeled "Mid dorsal tongue margin" is a 3.1 x 0.4 x 0.3 cm, fragment of red-tan tissue. Submitted in toto in one cassette for frozen section. B. Received fresh and labeled "Posterior dorsal tongue margin" is a 1.6 x 0.3 x 0.3 cm, red-tan soft tissue fragment. Submitted in toto in one cassette for frozen section.. C. Received fresh and labeled "Anterior dorsal tongue margin" is a 2.7 x 0.3 x 0.3 cm, yellow-tan soft tissue fragment. Submitted in toto in one cassette for frozen section. D. Received fresh and labeled "Posterior dorsal tongue margin" is a 1.2 x 0.3 x 0.3 cm, red-tan soft tissue fragment. Submitted in toto in one cassette for frozen section. E. Received fresh and labeled "posterior floor of mouth" is a 1.2 x 0.3 x 0.3 cm, red-tan soft tissue fragment. Submitted in toto in one cassette for frozen section. E. Received fresh and labeled "Anterior floor of mouth margin" is a 0.9 x 0.3 x 0.3 cm, red-tan soft tissue fragment. Submitted in toto in one cassette for frozen section. Received fresh and labeled "Anterior ventral tongue margin" is a 1.9 x 0.3 x 0.2 cm, G. red-tan soft tissue fragment. Submitted in toto in one cassette for frozen section. H. Received fresh and labeled "Anterior deep tongue margin" is a 1.2 x 0.3 x 0.3 cm, yellow-tan soft tissue fragment. Submitted in toto in one cassette for frozen section. I. Received fresh and labeled "Posterior deep tongue margin' is a 1.3 x 0.5 x 0.3 cm, red-tan soft tissue fragment. Submitted in toto in one cassette for frozen section. J. Received fresh. and labeled "Lingual nerve margin" is a 0.3 x 0.2 x 0.2 cm, white-tan soft tissue fragment. Submitted in toto in one cassete for frozen section.. K. Received in formalin and labeled "Left sublingual gland" is a white-tan soft tissue fragment, 3.7 x 1.8 x 0.7 cm. The specimen is inked black. Submitted in toto in four cassettes. L. Received in formalin and labeled "Left neck Ievels II, III and Iv" is a yellow-tan adipose tissue fragment, 8.5 x 4.5 x 3.2 cm in aggregate. Multiple lymph nodes were This  report is privileged, confidential and exempt from disclosure under applicable law. If you receive this report inadvertently, please call. return the report to us by mail..
+
+--- Page 6 ---
+PAGE 6 (Continued) GROSS DESCRIPTION: (Continued) found in the adipose tissue. The largest node measures 3.5 x 1.1 x 0.6 cm.. Representative sections are submitted as follows:. Cassette #1-8: One bisected lymph node per cassette Cassette #9: One bisected lymph node Cassette #10-12: Four lymph nodes per cassette Cassette #13: Six possible lymph nodes Cassette #14-17: Nine possible lymph nodes per cassette M. Received in. formalin and labeled "Left glossectomy" is a partial glossectomy specimen, measuring 5.0 cm from anterior to posterior, 1.9 cm from superior to inferior and 3.5 cm from medial to lateral. Serial sections reveal a 3.6 x 1.9 x 1.6 cm, white-tan lesion with surface ulceration. The lesion is located 0.3 cm from the anterior margin, 0.3 cm from the posterior margin, 0.1 cm from the deep margin, 0.5 cm from the medial margin and 0.5 cm from the lateral margin. Representative sections are submitted as follows: Cassette #1: Tumor with deep margin Cassette #2: Tumor with anterior margin Cassette #3: Tumor with posterior margin Cassette #4: Tumor with medial margin Cassette #5: Tumor with lateral margin Cassette #6&7: Tumor resected from the medial side Cassette #8: Tumor resected from the lateral side N. Received in formalin and labeled "Left neck dissection, level Ib" is a brown-tan soft tissue fragment, 4.5 x 3.4 x 2.1 cm. Four possible lymph nodes are found in the adipose tissue with presence of segment of salivary gland, 3.5 x 3.0 x 2.5 cm. The largest node measures 2.5 x 1.5 x 0.8 cm. Representative sections are submitted as follows: Cassette #1-3: One bisected lymph node per cassette Cassette #4: One possible. lymph node with surrounding adipose tissue. Cassette #5: Section of grossly unremarkable salivary gland. O. Received in formalin and labeled "Left neck dissection, level IA" is a yellow-tan soft largest node measures 1.1 x 0.7 x 0.5 cm. Representative sections are submited as follows: Cassette #1: Largest lymph node bisected If you receive this report inadvertently, please call. law. return the report to us by mail.
+
+--- Page 7 ---
+PAGE 7 (Continued) GROSS DESCRIPTION: (Continued) Cassette #2: One lymph node bisected. Cassette #3: One lymph node bisected. Cassette #4&5: Additional adipose tissue for more lymph nodes Received in formalin and labeled "Left external jugular vein node" is a yellow-tan. soft tissue fragment, measuring 2.0 x 1.7 x 0.6 cm. The specimen is bisected and. submitted in toto in two cassettes. Q Received in formalin and labeled "Fatty tissue on left facial vein" is a yellow-tan soft tissue, 1.5 x 0.8 x 0.5 cm. The specimen is bisected and submitted in toto in one cassette. OPERATING ROOM CONSULT(FS-CYT) A. MID DORSAL TONGUE MARGIN, FS: Negative for carcinoma. B. POSTERIOR DORSAL TONGUE MARGIN, FS: Negative for carCinoma. c. ANTERIOR DORSAL TONGUE MARGIN, FS: Negative for carcinOma. D. POSTERIOR VENTRAL TONGUE MARGIN, FS: Negative for carcinOma. E. POSTERIOR FLOOR OF MOUTH MARGIN, FS:  Negative for carcinoma. F. ANTERIOR FLOOR OF MOUTH MARGIN, FS:  Negative for carcinoma.. G. ANTERIOR VENTRAL TONGUE MARGIN, FS: Negative for carCinoma. H. ANTERIOR DEEP TONGUE MARGIN, FS:  Negative for carcinoma.. I. POSTERIOR .DEEP TONGUE MARGIN, FS: Negative for carcinoma. J. LINGUAL NERVE MARGIN, FS: Negative for carcinoma. This report is privileged, confidential and exempt from disclosure under applicable law. If you receive this report inadvertently, please call. return the report to us by mail. 419/13 ISQUALFIED
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diff --git a/output/text/da10027b-7cf9-4932-ac7b-dc1164be03f3.txt b/output/text/da10027b-7cf9-4932-ac7b-dc1164be03f3.txt
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index 0000000000000000000000000000000000000000..382992424434c1b1519fefa2e6e166f8ec0f5df7
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+--- Page 1 ---
+Patient Results. Anatomical Pathology results - Performed from UUID:58B63340-2A48-4ACB-A6D0-D8DF68A05889 TCGA-UD-AAC5-01A-PR Redacted M istopathology At least I Final Result Histopathology Final LAB. NO. PATIENT ADDRESS DOCTOR WARD sex REQUEST DATE D.0.B. DATE RECEIVED CONSULTANT SPECIMEN: A. Bronchial lymph node  Mediastinal lymph node C. Extrapleural pneumonectomy D. Thymic lymph node CLINICAL : Extrapleural pneumonectomy for mesothelioma. Submitted bronchial, mediastinal, thymic lymph nodes and pericardial fluid. Superior part of specimen sent for research and anteromedial part re-attached (resected separately). MACROSCOPIC: A. Two dark tan/black lobulated pieces of tissue each 9 x 7 x 6mm and 7 x 5 4mm. The larger specimen is bisected.. A  lobulated tan/grey piece of tissue, 15 x 10 x 8mm with surrounding blood clot. The specimen is bisected. ICw-o-3 BLOCK KEY: 1:node, 2:blood clot C. The specimen consists of a 1464g (post-fixation) left  extrapleural pneumonectomy specimen (250 x 230 x 90mm) consisting of lung, 145mm (anterior/posterior) x 40mm (medial/lateral) x 165mm), parietal pleura, pericardium (105 x 95 x 5mm) and hemi-diaphragm (185 x 80 x 25 to 8mm).  The apical,  anterior, lateral and posterior parietal pleural surfaces are grossly thickened and exhibit subtle diffuse firm pale nodulation.  The medial parietal pleural surface above the hilum also shows similar. appearances. Multiple foci of small whitish tumour nodules are present within the inner aspect of the parietal pericardium, extending over an area' of 65 x 55mm. There is a defect in C38. the anterolateral pleural wali, 70 x 35mm in area, which most likely represents specimen taken for research prior to receipt.. There are eight anthracotic hilar nodes, ranging in size from 15 x 6 x 5mm to 7 x 4 x 4mm, of which only the smallest shows macroscopic involvement by tumour. The specimen is serially sliced transversely into multiple slices from apex to hemi-diaphragm, revealing firm, rind-like cream/white tumour encasing the entire circumference of the parietal pleura. In areas, there is fusion of the parietal and visceral pleura with a large loculated effusion present laterally. Tumour extends into the interlobar septa and into the subpleural lung parenchyma to a maximum depth of 17mm.  There is extensive involvement of mediastinal. fat as demonstrated by intersecting bridges of firm white tumour.  Tumour lies in close proximity to the anterior and posterior pericardial resection margins as well as the medial, lateral, anterior and posterior diaphragmatic resection margins. Photographs taken. BLOCK KEY: 1:bronchial line of resection, 2-5:hilar lymph nodes, 6:hilar lymph node, metastatic tumour, pericardium resection margin, 9:anterior diaphragm resection margin, 10:posterior diaphragm resection margin, ll:medial diaphragm resection margin, 12:lateral diaphragm resection margin, 13:additional hilar nodes, 14,15:lateral parietal pleura, 16:parietal and visceral pleura with diaphragm,  17-19:medial pleura, 20-22:visceral pleura (lateral, involving lung), 23,24:tumour and mediastinal fat, 25-27:tumour and lung, 2 28:tumour and lateral pleura, 29:non- surface. D. Fatty tissue, 20 x 15 x 7mm within which is an anthracotic lymph node, 13 x 7 X 6mm. There appears to be no macrosranic tumour involvement..  The specimen is bisected. Requested by: Printed from: : Page: I of's.
+
+--- Page 2 ---
+Patient Results Anatomical Pathology results - Performed from M Histopathology At least I Final Result  MICROSCOPIC: A. The sections show a lymph node laden with histiocytes containing  carbon pigment.  Within the subcapsular sinus, there is one small focus of metastatic mesothelioma, less than lmm, with focal 'extra capsular' extension to a distance of less than 0.5mm. B. The sections show shows a lymph node with one small focus, 1.5mm, of metastatic malignant mesothelioma.  Multiple sections of the left extrapleural pneumonectomy C. were taken, including the various resection margins from anterior and posterior pericardium, anterior, posterior,  lateral and medial diaphragm, parietal pleura. and mediastinal fat. The sections confirm..malignant mesothelioma.  exhibiting predominantly an epithelial growth pattern with.a very small component (5%) of sarcomatous pattern. The vast majority'of the tumour is characterised  by pavement-like  sheets of large cells often exhibiting a microcystic growth pattern with focal necrosis. There is abundant pale basophilic material,. confirmed to be hyaluronate on an Alcian blue/hyaluronidase stain. The malignant cells  possess monotonous, round to oval to.mildly pleomorphic vesicular nuclei,. prominent nucleoli and abundant, often yacuolated cytoplasm.  In focal areas the cells exhibit a spindled morphology, intermixed with moderate amounts of dense collagen. Lymphovascular space invasion is noted.. There is extensive involvement of all parietal  pleural resection margins. Tumour lies close to the anterior pericardial resection margin, as well as the anterior, posterior, medial and lateral. diaphragmatic resection margins. There is  subpleural extension into lung and extension to the internal surface of the pericardium. The  sections also confirm invasion of the mediastinal fat. The bronchial  resection margin is clear of tumour and there is no invasion of the bronchial tree at the hilum (described macroscopically)..  Of eight hilar lymph nodes retrieved, one small lymph node shows near ~complete replacement metastatic tumour with extracapsular extension to a distance of 0.5mm.. D. The  sections show a lymph node with abundant histiocytes containing  carbon pigment. There is no evidence of micrometastasis identified by light microscopy. CONCLUSION: A. Bronchial lymph node: Micrometastasis, less than 1mm, of metastatic mesothelioma,  with focal extracapsular extension.. B. Mediastinal lymph node: Micrometastasis, l.5mm, of malignant mesothelioma. C. Extrapleural pneumonectomy: 1. Extensive involvement by malignant mesothelioma, predominantly of epithelial pattern, with focal (5 % or less) sarcomatous pattern.. 2. Tumour 'lies focally close to anterior pericardial resection margin and. anterior, posterior, medial and lateral diaphragmatic resection margins. There is  subpleural invasion of the lung parenchyma and extension to the internal surface of the pericardium..  Involvement beyond the parietal pleural margin is extensive  with invasion into mediastinal fat. Bronchial resection margin is clear of tumour. 3. Of  eight  hilar lymph nodes, one is.positive with focal extracapsular extension (1/8). D. Thymic lymph node: Negative for malignancy, no micrometastases.. REGISTRAR: PATHOLOGIST: DOCTOR REVIEWING: DATED: ELECTRONICALLY VALIDATED: Criteria 11//9/13 Case is (circle Requested by: Printed from:  Page: 2 of 3.
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diff --git a/output/text/da46a7d8-2b2c-4707-91be-3736e185ab8c.txt b/output/text/da46a7d8-2b2c-4707-91be-3736e185ab8c.txt
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index 0000000000000000000000000000000000000000..9d5e09d0a4fb3018b7273c9d438001c2bce7199d
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+--- Page 1 ---
+Report SURGICAL PATHOLOGY UUID:63266BCF-52D2-4EFC-ADD4-B77288D8101E RGICAL PATHOLOGY tcgA-Qg-A5z1-01A-pr Redacted S PORT Accession No. Date obtained: CAO 4/1/i3 CcF Specimen (Received A. LOW ANTERIOR RESECTION/STITCH MARKS PROXIMAL MARGINS  PROXIMAL DONUT C. DISTAL DONUT BRIEF CLINICAL HISTORY: C PREOPERATIVE DIAGNOSIS: N6S RECTO-SIGMOID ADENOCARCINOMA OpERATIVE FINDINGS: POSTCPERATIVE DIAGNOSIS: 814s/3  RECTO-SIGMOID ADENOCARCINOMA Surgeon/physician: Q18.7 PATHOLOGY REPORT Laboratory: GROSS DESCRIPTION: A. The specimen consists of 2l.0 cm in length segment of colon, stapled at both ends with moderate amounts of attached fat. The specimen is received fresh to the frozen section lab for intraoperative gross consultation.. Intraoperative findings are communicated to the surgeon in person.  The serosa is tan-pink, smooth and glistening. There is a firm area of puckering in the mid portion. of the serosa. The serosal aspect with the puckering is inked blue. Opening reveals a 2.8 x 2.5 cm, tan-pink, centrally ulcerated mass with raised borders that is nearly circumferential, 9.5 cm from the proximal resection margin, and 5.8 cm from the distal resection margin. Sectioning through the mass reveals a tan-white,. granular cut surface that grossly extends into the underlying attached mesenteric fat. The mass does not grossly extend to the inked serosal aspect. The mass is 9.3 cm from the mesenteric resection margin. The remaining colonic mucosa is tan-brown, smooth and glistening. No subsequent lesions are identified. Sectioning through the attached fat reveals multiple tan-pink, rubbery lymph nodes ranging from 0.3 to 0.8 cm in greatest dimensions. Representative sections are submitted as follows: Al- proximal resection margin; A2- distal resection margin; A3-A4- mass to closest inked serosa; A5-A6- mass to include underlying fat and adjacent uninvolved mucosa; A7- mesenteric resection margin closest to mass; A8-A13- multiple whole lymph nodes.. GROSS DIAGNOSIS: RECTOSIGMOID COLON RESECTION: - TUMOR IDENTIFIED WITH MARGINS APPEARING GROSSLY FAR FROM THE MASS. B.  The specimen consists of a l.8 x l.0 x 0.6 cm, tan-brown, annular soft tissue partially surface by a tan-brown, smooth and glistening.  Sectioning reveals a tan-brown, unremarkable cut surface. No mucosa.
+
+--- Page 2 ---
+discrete lesions are identified.  Representative sections are submitted in cassette B. C.  The specimen consists of a 2.1 x 1.3 x 0.6 cm, tan-brown, annular soft tissue partially surface by a tan-brown, smooth and glistening NO mucosa. Sectioning reveals a tan-brown, unremarkable cut surface. discrete lesions are identified.  Representative sections are submitted in cassette C. MICROSCOPIC EXAM FINAL DIAGNOSIS: A. LOW ANTERIOR COLON, RESECTION: SPECIMEN TYPE: RECTOSIGMOID, EN, BLOC RESECTION. TuMor SITE: REctosIgMoID COLon. TUMOR CONFIGURATION: INFILTRATIVE. TUMOR SIZE: 2.8 CM IN GREATEST DIMENSION. HISTOLOGIC TYPE: ADENOCARCINOMA HISTOLOGIC GRADE: WELL DIFFERENTIATED (G2).  SURGICAL MARGINS PROXIMAL COLORECTAL: NEGATIVE DISTAL COLORECTAL: NEGATIVE  RADIAL: NEGATIVE DISTANCE OF INVASIVE CARCINOMA FROM NEAREST SURGICAL MARGIN: 5.8 CM FROM DISTAL MARGIN. - LYMPHATIC INVASION: PRESENT. - VASCULAR INVASION: PRESENT. -PERINEURAL INVASION: PRESENT. PATHOLOGIC STAGING (pTN) :  PRIMARY TUMOR: pT3. REGIONAL LYMPH NODES: pNIb. NUMBER EXAMINED: 38 NUMBER INVOLVED: 3 ADDITIONAL DIAGNOSES: - TUBULAR ADENOMA ASSOCIATED WITH ADENOCARCINOMA. B. PROXIMAL COLONIC DONUT, RESECTION: SEGMENT OF COLON, NO TUMOR SEEN. C. DISTAL COLONIC DONUT, RESECTION: - SEGMENT OF COLON, NO TUMOR SEEN. COMMENT: THE TUMOR IS O.5 CM FROM THE SEROSAL REGION IN FOCAL AREAS AWAY FROM THE SURGICAL SEROSAL MARGINS. THE ORIGINAL DIAGNOSIS FROM CONCURS WITH MALIGNANCY DIAGNOSIS. ALEXANDRIA WAS CORRELATED. DR. IMAGES ARE AVAILABLE IN VISTA. NOTIFIED VIA ALERT ON MD Sianec End MD 2/30/13 QUALISED
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diff --git a/output/text/da6b2b75-43ba-4ad0-a115-3b865d0cc614.txt b/output/text/da6b2b75-43ba-4ad0-a115-3b865d0cc614.txt
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index 0000000000000000000000000000000000000000..7190d8450f75a5faf6e9d0d4753ffeac53d2958a
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+
+--- Page 1 ---
+UUID:4FC34715-9004-4F53-B914-F0004AEA88C8 /CD -0 -3 TCGA-AR-A0TX-01A-PR Redacted Caiciomu mf1trutng oluctl, Nos 85o0/3 Site:buot, Nvs Csu.9 Breast, left, wide local excision: Infiltrating ductal carcinoma, Nottingham grade II (of IIl), forming a. multilobulated mass (1.5 x 1.2 x 1.0 cm) adjacent to the prior core biopsy site (AJCC pT1c). Ductal. carcinoma in-situ, solid type, high nuclear grade, is present outside the main tumor mass. No. angiolymphatic invasion is identified. The skin is without diagnostic abnormality. All surgical resection margins, after re-excision of the deep margin (skeletal muscle), are negative for tumor (minimum tumor. free margin, 0.4 cm, superior margin).. Lymph nodes, left axillary, dissection: Multiple (3 of 25) left axillary lymph nodes are positive for metastatic carcinoma with extranodal extension (AJCC pN1). Two positive lymph nodes are matted. together. Her-2/NEU has been ordered on paraffin embedded tissue.
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diff --git a/output/text/da70974d-bdbc-41f1-bca2-6c6e02e0d12e.txt b/output/text/da70974d-bdbc-41f1-bca2-6c6e02e0d12e.txt
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index 0000000000000000000000000000000000000000..9808b349d701ad43dcc5efb52e43dba040b96194
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+
+--- Page 1 ---
+UUID:C4748884-0E7E-46FB-91C6-0BEA58695974 TCGA-C8-A133-01A-PR Redacted ...nical Case Report (For Collection of Cancerous Tissue) 1cs-0-3 tarce`nu, n`fit+raHwg cucHL sd muciNons 85a31.3 3its: bruA N0s C5O.9 10/37/n Informed Consent I personally informed this patient that a specimen(s) would be collected t he used for research purposes.I reviewed the yith the patient and answered any questions the patient had. The patient then signed the. consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator Signature Date Clinical Information AASGENERALINFORMATIONRS Date of Birth (mm/dd/yyyy) Height Marital Status  Race Temperature 167 cm  Single trMarried 9 8 C Gender Weight  Divorced  Widow Blood Pressure Heart Rate  Male VFemale 67 Kq 120/00 $2 7 *HISTORYOFPRESENTILLNESS Chief Complaints: Right Breast lump Symptoms: Pain .Swcllng and Clinical Findings: Ca ? Performance Scale (Karnofsky Score):  100 Asymptomatic  80-90 Symptomatic but Fully Ambulatory  60-70 Symptomatic, in bed less than 50% of day  20-30 Bed Ridden  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden. PWSROOSCURRENT MEDICATIONSPO Drug Dose Route Frequency Date (mm/dd/yyyy) 3o mg Coe Onyting Tb.Diamicsto Oral Oral igs.Aldacln ivomg 0.) To Ohdairy 40 mj Ts. Cral L.Qsix To Ondhin i0my Ora? B-D Tah. 23.D :o Cap.Rutiny Le Oral Ac t sjs. J HhmihnR I M. nj ecuon
+
+--- Page 2 ---
+PAST MEDICAL HISTORY Diagnosis/Disease/Disorder/Injury  Diagnosis Date Treatment Status K/e o/ HTN .  *OBGYNHISTORY+ Date of First Menses # of Pregnancies Menopausal Status y/s  Pre-menopausal Date of Last Menses # of Live Births  Peri-Menopausal N/s. L- Post-menopausal  IUD  Hormone Replacement Birth Control:  Condom Oral Contraceptive NIs. Therapy:_ Nis:  Other: KAW RSOCIALHISTORYNSCAw.*... Environmental Hazards: Occupation:  Smoking History  Packs/day Duration When Quit Current Status Type (yrs)  (yt)  YES 4NO Alcohol Consumption Duration When Quit. TYPE Drinks/day Current Status (yrs) ] (yr)  yes  NO Drug Use Duration When Quit TYPE Frequency Current Status (yrs) (yr YES wNO AFAMILYMEDICALHISTORYNSM. Age of Diagnosis Diagnosis Relative WWLABDATA W Result Date Date Test Test Result CEA  Negative  Positive: HIV  Negative  Positive: CA 15-3  Negative  Positive:  Hep B Negative  Positive: CA 19-9   Negative  Positive: Hep C Negative  Positive: PSA   Negative  Positive:   Negative  Positive: AFP Other:  Negative  Positive: Other:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+ + + ++s T+++ DIAGNOSTIC STUDIES/S *+++* Study ....  Results Date Ultrasound X-Ray CT Endoscopy MRI Biopsy 2 * ++SWAX OCLINICAL DIAGNOSIS W+++   C Preoperative Clinical Diagnosis Rt Bueast . lume Ca ?  Location of Suspected Involved Lymph Nodes Location of Suspected Distant Metastasis Clinical Staging Date of Diagnosis T N m Stage: Treatment Information ++*    SURGICALTREATMENT Procedure Date of Procedure Moditied Raoicrl  Mlasteelomy (MRM)  Primary Tumor Organ Detailed Location Size Right. Breast: 3.5x S x4 cm Extension of Tumor Lymph Nodes Description Location of Lymph Nodes # of Lymph Nodes. Palpable, Non-Dissected Lymph Nodes 1/26 Dissected Lymph Nodes Distant Metastasis Organ Detailed Location Size Surgical Staging t N M Stage:  NEOADJUVENTTHERAPY (Chemo, Radiation, Immuno Hormonal, or Molecular)/ Dose Route Frequency Date (mm/dd/yyyy) Drug/Treatment To 1 1 To 1 / To 1 To To 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by: Date: ... ..me: Preserved by: Date. Time: SPECIMEN TYPE (#of samples provided): .. Frozen Paraffin Block  Btood/Serum/Plasma Slide Normal Diseased Normal Diseased Normal Diseased Normal Diseased 1 Time to LN2 Time to Formalin Time to LN2 30 min 30 min 30 min +*LPATHOLOGICALDESCRIPTION  +. Primary Tumor Organ Size Extension of Tumor Distance to NAT Right Bseast K5 x S x Ycm cm Lymph Nodes # Examined # Metastasized Location 26 1/2- Distant Metastasis Detailed Location Size  Organ Pathological Staging 7LA N j M o Stage: pT3 Notes: 4
+
+--- Page 5 ---
+Microscopic Description w..rwwHistologicalPattrn.www Cell Distribution Structural Pattern +  Diffuse Streaming Mosaic  Storiform Necrosis  Fibrosis Lymphocytic Infiltration Palisading  Vascular Invasion Cystic Degeneration Clusterized  Bleeding  Alveolar Formation Myxoid Change  Indian File Psammoma/Calcification w sCelularDifferentiationa Squamous +- Adenomatous + Sarcomatous + Lymphomatous  Squamoid Cell Glandular cel! Round Cell Large Cell Cell Stratification Fibroblast Spindle Cell Small Cell Keratin Secretion Osteoblast RS Cell/RS Like Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell Peart Gland formation Myoblast  Plasma Cell Cellular Differentiation: Well Moderate  Poor ww.wwwwwwwwww.w..NuclearAppearancewwwwwww.* 0 1 II III Nuclear Atypia:  Aniso Nucleosis + Hyperchromatism Nudeolar Prominent Multinucleated Giant Cell Q Mitotic Activity Nuclear Grade: w.wwweHcDatawww Result Value Date Marker ER  Negative Positive PR Negative  Positive  Negative  Positive Her-2/neu B-Cell Marker  Negative  Positive T-Cell Marker  Negative   Positive Other:  Negative  Positive Other:  Negative   Positive Fina! Pathology Report Caiten ew e mceiou Qu.iy Masive luclol Histological Diagnosis: Grade: Comments: Date Pathologist  Princ-al Investigator 5
+
+--- Page 6 ---
+COnsOLIdated DiagNOstIc pathOLOgy fOrm* Microscopic Appearance: 1. Histological pattern: CELL DISTRIBUTION Diffuse + STRUCTURAL PATTERN Streaming + Mosaic K  Storiform Necrosis Fibrosis Lymphocytic Infiltration Palisading Vascular Invasion X Cystic Degeneration Clusterized Alveolar Formation Blceding Myxoid Change Indian File X Psammoma/Calcification 2. Cellular features: Squamous + Adenomatous +  Sarcomatous  Squamoid Cell +- Lymphomatous Glandular cell 0  Round Cell Spindle Cell Large Cell Cell Stratification Fibroblast Small Cell Keratin  Secretion Osteoblast  RS Cel/RS Like Desmosome Intracyt. Vacuole Lipoblast Inflam. Cell Pear! Gland formation Myoblast Plasma Cell Otherwise Specified: ceees : 357 Cellular Differentiation: Well  Moderately Poor 3. Nuclear Atypia: Nuclear Appearance IJ  Aniso Nucleosis Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity Nuclear Grade Histological Diagnosis:Izpltsany retel Caxere, 2 Nuiendt Comments: Date Director, Research Pathology PATHOLOGIST STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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diff --git a/output/text/da729360-c52e-4fc9-b11d-fdfdd2ee83bd.txt b/output/text/da729360-c52e-4fc9-b11d-fdfdd2ee83bd.txt
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index 0000000000000000000000000000000000000000..774515608075e2deff52fc5f129ff37b79b45d38
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+
+--- Page 1 ---
+TCGA-AL-3466 SURGICAL PATHOLOGY REPORT Clinical History/Diagnosis: Right renal cancer, IVC thrombus. Source of Specimen(s): A: Lymph Node, inter aorta caval. B: Thrombus. C: Right kidney. D: Lymph Node, retro caval Gross Description: Received in four parts. Source of Tissue: 1. Labeled #1 "inter-aortocaval Iymph node" Gross Description: The specimen is received fresh and consists of a reddish-tan ovoid rubbery nodule measuring 3 x 2.5 x 2.5 cm. Sections show tan homogeneous cut surface consistent with metastatic disease.. Representative sections in 1A. Designation of Sections: Summary of Sections: ************************************************************************ Source of Tissue: 2. Labeled #2 "thrombus". Gross Description: The specimen is received fresh and consists of a few fragments of tan to red friable tissue and some blood clot measuring collectively 4 x 3.5 x 1.5 cm. It appears to be predominantly lesional tissue. Representative sections in 2A.. Designation of Sections: Summary of Sections: ************************************************************************ Source of Tissue: 3. Labeled #3 "right kidney'. Gross Description: The specimen is received fresh and consists of a right kidney weighing 640 gm and measuring 12 x 10 x 8 cm. A small amount of attached perinephric fat is present measuring up to 2 cm from point of attachment. No adrenal gland is found. At the hilum, a segment of ureter is present measuring 8 x 0.4 cm and is unremarkable. Also at the hilum, is a renal vein. The renal vein is markedly distended, ragged, and grossly contains tan friable lesional tissue. There is also an. appreciable amount of subcapsular hemorrhage posteriorly. The specimen is bivalved revealing a large white firm tumor measuring 8 x 6 x 6.7 cm. The tumor infiltrates throughout the kidney and grossly comprises
+
+--- Page 2 ---
+approximately 80% of the left kidney. The calyceal system is grossly involved by tunor and it comes to within 1 cm from the hilum. There is a small amount of somewhat normal appearing kidney with the usual cortical medullary rays. No additional lymph nodes are found. Photographs were taken. Fresh tissue procured for cytogenetic studies. Designation of Sections: 3A ureter and vascular margins, 3B additional. section of renal vein adjacent to margin, 3C tumor, 3D tumor in relationship to hilum/ureter, 3E tumor in relationship to capsule, 3F tumor in relationship to normal adjacent tissue and subcapsular. hemorrhage, 3G tumor in relationship to inferior calyx, 3H uninvolved left. kidney, 3I-3J perinephric fat. Summary of Sections: A-J. ************************************************************************ Source of Tissue: 4. Labeled #4 "retrocaval lymph node" Gross Description: The specimen is received fresh and consists of an ovoid. reddish-tan rubbery nodule measuring 6.5 x 5.5 x 3.5 cm. Sections show approximately 25% of the node to be necrotic. Elsewhere, tan cut surface consistent with metastatic disease is present. Representative sections submitted in 4A and 4B. Designation of Sections: Summary of Sections: Final Diagnosis: 1. Lymph node, inter-aortocaval (excision): - Metastatic papillary renal cell carcinoma. 2. Thrombus, site not specified (excision): - Papillary renal cell carcinoma present.. 3. Right kidney (right nephrectomy):. - Renal cell carcinoma, papillary type,. - The tumor measurgs .8 cm in greatest diameter. - Tumor invades into renal vein and extends to the renal vein margin of. resection. - Tumor involves the lymphatics of the vascular margin. - Negative ureteral margin. 4. Lymph node, retrocaval (excision):. - Metastatic papillary renal cell carcinoma. Note: The tumor shows extensive lymphatic invasion.
+
+--- Page 3 ---
+Procedures/Addenda Results-Comments CYTOGENETIC ANALYSIS REPORTS KARYOTYPE: karyotype with nonclonal abnormality: 46,XY[19]/38,X,-Y,?add(1) (p13),del(3)(p11.2),-4,-4,-6,-7,del(9)(p22),+?13,-14,-17,-18,-18,-19,-21, add(21)(p11.2),-22,+3mar[1] RESULTS: The renal tumor sample was sent to a commercial laboratory for cytogenetic analysis. The chromosomes from twenty metaphases were counted and analyzed, and two of these metaphases were karyotyped by G-banding.. Nineteen cells had a modal chromosome number of 46, and the cells appeared to have a normal karyotype. One nonclonal cell contained nonrepetitive chromosomal changes that included a deletion in the short. arm of chromosome 3. This deletion has been reported in cases of nonpapillary renal cell carcinoma. Partial analysis of additional metaphases failed to. detect other aberrant cells.
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diff --git a/output/text/dab07318-c51a-4758-aa37-a637d9aee1d9.txt b/output/text/dab07318-c51a-4758-aa37-a637d9aee1d9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8a8b9f2778227f2a3bed325d1aa21f52bf8dff59
--- /dev/null
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+
+--- Page 1 ---
+Diagnosis: Ileocolic resection material includes a moderately differentiated adenocarcinoma of the colorectal type in the transverse colon, 6.5 cm from the aboral resection margin, with central ulceration and with incipient infiltration of the pericolic fatty tissue (maximum infiltration depth in the perimuscular fatty tissue at the histological section less than 1 mm). Tumor-free regional lymph nodes. Tumor-free resection margins of small intestine and colon Tumor-free mesenteric resection margin. Tumor-free appendix. Tumor-free fatty tissue of the omentum. Also so-called retention polyp of the colon mucosa.. Tumor stage: pT3 pN0 (0/41) pMX; G2, L0 V0 R0
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diff --git a/output/text/dad4b27a-2546-4139-a0d7-11e8e24e5b69.txt b/output/text/dad4b27a-2546-4139-a0d7-11e8e24e5b69.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8e27b87a518748e8bdc7774cd29ac4c3f57e24f4
--- /dev/null
+++ b/output/text/dad4b27a-2546-4139-a0d7-11e8e24e5b69.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UUID: 32800FA9-9865-4E4C-982C-010849E32CD8 TCGA-LN-A49Y-01A-PR Redacted Tel: Fax: Clinical Case Report (For Collection of Cancerous Tissue) 1cs-0 -3 CuceRon7 Aquemoro call,iN0s 8or0/3 Site+ 2ssphezue, middl Hhul C15,y lw 10/12 Informed Consent I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informerd consent document will be retained at. our institution. Name of Physician or Study Coordinator Date Clinical Information GENERAL INFORMATION Date of Birth (mm/dd/yyy) Height Marital Status Race Temperature g 6 Q Single Married Gender Weight  Divorced  Widow  Blood Pressure Heart Rate Male  Female 57ko HISTORY OF PRESENT ILLNESS Chief Complaints: Fevl "T^wuble e 9WalloWinq Symptoms: Weinhf Ws? Clinical Findings:  Performance Scale (Karnofsky Score):  100 Asymptomatic   80-90 Symptomatic but Fully Ambulatory  60-70 Symptomatic, in bed less than 50% of day  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden r20-30 Bed Ridden CURRENTMEDICATIONS Drug Dose Route Freguency Date (mm/dd/yyyy) To To 1 To To 1 To
+
+--- Page 2 ---
+PAST MEDICAL HISTORY  Diagnosis Date Treatment Status Diagnosis/Disease/Disorder/Injury OM OBGYN HISTORY Date of First Menses. # of Pregnancies Menopausal Status  Pre-menopausal Date of Last Menses # of Live Births  Peri-Menopausal  Post-menopausal Birth Control:  Condomd  Oral Contraceptive  IUD  Hormone Replacementd Therapy:  Other: OSRSOCIALHISTORY Environmental Hazards:d Occupation:  Smoking History  Packs/day Duration When Quit Current Status TYPE (yrs) ( YES yNO Alcohol Consumptiond  Drinks/day Duration When Quit Current Status TYPE 2doms(day (yrs) Csaa).. (r gDYES NO Drug Use Duration When Qult Current Status TYPE Frequency (vrs) yr)  YES NO FAMILYMEDICALHISTORY Age of Diagnosis  Relative  Dlagnosis LABDATA  Result Date  Result Date Test Test CEA  Negative  Positive: HIV Negative  Positive: CA 15-3 Negative  Positive: Hep B #Negative  Positive:  CA 19-9 Negative.  Positive: Hep C Negative  Positive:  PSA Negative  Positive: AFP Negative  Positive: Other: Other:  Negative  Positive:  Negative  Positive: B/T Cell Markers:
+
+--- Page 3 ---
+DIAGNOSTIC STUDIES Study Results Ultrasound Date X-Ray CT Endoscopy  MRI Biopsy Caqcinoma CLINICAL DIAGNOSIS Preoperative Clinical Diagnosis Location of Suspected Invoived Lymph Nodes Location of Suspected Distant Metastasis Clinical Staging Date of Diagnosis. t3 No Mo Stage: I A- Treatment Information  SURGICAL TREATMENT Procedure Qesectim Date of Procedure oesophacgus  Primary Tumor Organ  Detailed Location Size e so puaF is midelle I xc8x Extension of Tumor am Lymph Nodes Description Locatlon of Lymph Nodes # of Lymph Nodes Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis  Organ  Detailed Location Size Surgical Staging I 3. No ma Stage:I! NEOADJUVENT THERAPY (Chemo, Radiation, Immuno, Hormonal, or Molecular) Drug/Treatment Dose Route Frequency Date (mm/dd/yyyy) To 1 1 1 To 1 1 To 1 To 1 ! To 1 1
+
+--- Page 4 ---
+Pathology Form Specimen Informationd Date: Time: Collected by: .. Time:_ Date: Preserved by: ..   SPECIMaN TYPE (# of saaples provided) : Blood/Sersm/Plasms Slide Frozen Paraffim Biock Diseased  Normal Diseased Normal Normal Diseased  Normal Diseased 2 2 2 2 2 Time to Formalin Time to LN2 Time to LN2 min min 10 min PATHOLOGICAL DESCRIPTION Primary Tumor  Extension of Tumor Distance to Nat Size Organ 6 1 xO8x cm midelle cm eseDrgis Lymph Nodes # Examined # Metastasized Location Distant Metastasis  Detailed Location Size Organ. Pathological Staging N o m o Stage: ILA pT 3 Notes: 4
+
+--- Page 5 ---
+COnsOLIdaTeD DIagNOstIc pAthOLOgy fOrm* Microscopic Appearance: 1. Histological pattern: CELL DISTRIBUTION Diffuse STRUCTURALPATTERN Streaming Mosaic + Necrosis Storiform Lymphocytic Infiltration Fibrosis Vascular Invasion Palisading Clusterized Cystic Degeneration Alveol Formation X Bleeding Myxoid Change Indian Filo Psammoma/Calcification 2. Celluiar Seatures: Sguamous Adenomatous + Sarcomatous Squamoid Cell Lymphomatous I. Glandular cell Round Cell Spindle Cell Large Cell Cell Stratification Fibroblast Keratin Small Cell Secretion Osteoblast RS Cel/RS Like Desmosome X Intracyt. Vacuole Lipoblast Inflam. Cell Pear! XGland formation Myoblast  Plasma Cell Otherwise Specified: D807 45o% 2.Cellular Differentiation: Well  Moderauely Poor X Nuclear Atypia: Nuclear Appearance  Aniso Nucleosis Hyperchromatism.  Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity. Nuckar Grade Sgularons Cel Carcihmg. Histological Diagnosis.. Comments: Date Director, Kesearcn rauviuky PATHOLOGIST STAFF FOR RESEARCH USE ONLYJ. *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR ANDS AAD
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diff --git a/output/text/db2832f7-bfe7-466b-8b25-b23f7251f4f5.txt b/output/text/db2832f7-bfe7-466b-8b25-b23f7251f4f5.txt
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index 0000000000000000000000000000000000000000..9827c24da5f7eac8e2e42568a952633d184b66e7
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+
+--- Page 1 ---
+** Case imported from legacy computer system. The format of this report does not match the original case. **. **For cases prior to the section SPECIMEN"may have been added.** SUPPLEMENTAL REPORT A) LEFT NECK DISSECTION, MANDIBULECTOMY,FLOOR OF MOUTH ALVEOLECTOMY, AND RADICAL RESECTION OF FACIAL SKIN: TUMOR INVOLVES CORTICAL BONE. Entire report and diagnosis completed by: DIAGNOSIS LEFT NECK DISSECTION, MANDIBULECTOMY, FLOOR OF MOUTH ALVEOLECTOMY, AND RADICAL RESECTION OF FACIAL SKIN: MODERATELY DIFFERENTIATED SQUAMOUS CELL CARCINOMA, DEEPLY INVASIVE INVASIVE SQUAMOUS CELL CARCINOMA AT POSTERIOR MUCOSAL MARGIN; ALL OTHER MARGINS FREE OF TUMOR. No metastatic carcinoma in eight lymph nodes. TUMOR EXTENDS TO PAROTID GLAND. (B) ADDITIONAL POSTERIOR MARGIN, EXCISION: FOCAL SUPERFICIALLY INVASIVE SQUAMOUS CELL CARCINOMA. Margins free of tumor. (C) TEETH, EXTRACTION: Teeth with dental fillings. Entire report and diaanosis completed. GROSS DESCRIPTION ALEFT NECK DISSECTION, MANDIBULECTOMYFLOOR OF MOUTH ALVEOLECTOMY RADICAL RESECTION OF FACIAL SKIN -A 17.0 x9.0x 7.8 cm specimen which consists of a skin ellipse, underlying soft tissue, and attached portion of. mandible with associated mucosa and skeletal muscle. The skin ellipse is 10.0 x 7.0 cm and has a centrally located located raised soft erythematous nodule. The nodule is 2.0 x 1.8 cm. The skin margins are grossly unremarkable. The portion of mandibular bone is 6.0 x 3.0 x 1.4 cm and grossly uninvolved by tumor. The overlying mandibular mucosa/floor of mouth is pink-tan and slightly erythematous. The mucosa is 5.0 x 1.5 x 0.4 cm. Attached to the Page 1of3 History Case Pathology Report History Case Pathology File under: Pathology
+
+--- Page 2 ---
+mandible is skeletal muscle, salivary gland, and adipose tissue. The salivary gland abutts a firm tumor but appears grossly uninvolved.  The salivary gland is 3.0 x 2.5 x2.0 cm. The attached 1ymph node dissection is 11.0 x 3.0  1.0 cm. The attached skeletal muscle is 5.0 x 2.0 x 1.2 cm. A 4.5 x 4.0 x 3.5 cm firm spherical mass is present within the central aspect of the skin. The mass extends to abut the outer aspect of the mandible. The deep portion of the tumor bed is smooth and has a 0.4 cm skeletal muscle margin in the deep anterior and posterior region. The central aspect of the tumor is partially necrotic. The tumor appears to be grossly away from al1 surgical margins. The salivary gland has an unremarkable parenchyma. Multiple lymph nodes are identified. The largest lymph node measures 1.2 cm in greatest dimension.. There are no matted or necrotic lymph nodes present. A representative sample of this sample is submitted for frozen section and a representative sample of the remainder of the specimen is submitted for permanent fixation. INK coDe: Black = medial soft tissue and medial mucosal margin; orange = skin margin and mucosal margin on lateral aspect; yellow = deep/inferior aspect. The anterior mucosal margin is designated as 12 o'clock and the posterior mucosal margin is designated as 6 o'clock. SEctIoN coDe: A1, 12 o'clock-2 o'clock mucosal margin en face; A2, 2-5 o'clock mucosal margin en face; A3, 5-7 o'clock mucosal margin en face; A4, 7 o'clock to 9 o'clock mucosal margin en face; A5,9-12 o'clock mucosal margin en face; A6, anterior skin margin en face; A7, superior anterior skin margin en face; A8, superior posterior skin margin en face; A9-A10, posterior skin margin en face; A11, posterior inferior skin margin en face; A12, mid inferior skin margin en face; A13, anterior inferior skin margin en face;A14-A17, remaining mucosa submitted entirely sequentially from anterior to posterior in a perpendicular fashion; A18, A19, skin with underlying tumor; A20, tumor piece of skin; A21-A23, tumor with medial and deep skeletal muscle margin; A24, salivary gland with adjacent tumor; A25, unremarkable salivary gland; A26,one 1ymph node bisected; A27, one 1ymph node bisected; A28,four possible 1ymph nodes. *FS/DX INVASIVE SQUAMOUS CELL CARCINOMA AT POSTERIOR MUCOSAL MARGIN; OTHER MARGINS FREE OF TUMOR. B) ADDITIONAL POSTERIOR MARGIN LONG =NEW MID POSTERIOR MARGIN,SHORT= LINguAL MARGIn) - An oriented portion of pink-tan mucosal lined tissue which is 3.0 x 2.6 x 1.2 cm. The long suture is placed at 6 o'clock and the short suture is placed at 3 o'clock. The central aspect of the mucosal surface is slightly elevatedand erythematous. The elevated portion measures 1.0 x 1.0 cm. The deep aspect consists of smooth skeletal' muscle. INK coDe: Yellow = 2-7 o'clock; _orange =7-2 o'clock; black = deep. The specimen is submitted entirely following representative samples for frozen section. SEction coDe: B1, 2-4 o'clock mucosal margin en face; B2, 4-7 o'clock mucosal margin en face; B4, 9-12 o'clock mucosal margin en face; B5, 12-2 o'clock mucosal margin en face; B6-B10. entire specimen submitted sequentially from anterior to posterior aspect. *FS/DX:SQUAMOUS MUCOSA,NO TUMOR PRESENT. (C) TEeTH - Two molar teeth and two incisors, 1.8cm .9cm2.1cmand1.8 cm in length in length, respectively.  The two molar teeth contain a white and a silver filling, respectively.  Both incisors show what anpears to be porcelain grounds. The specimen is for gross only. Page 2 of 3 History Case Pathology Report History Case Pathology File under: Pathology
+
+--- Page 3 ---
+SNOMED CODES M-80703 T-11180 T-51200T-C4200 Page 3 of 3 History Case Pathology Report History Case Pathology File under: Pathology
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diff --git a/output/text/db4fffa7-af25-4e20-9483-cbc4d7d55a09.txt b/output/text/db4fffa7-af25-4e20-9483-cbc4d7d55a09.txt
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index 0000000000000000000000000000000000000000..638e46e9e898181af398d20d801155be24138f73
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+
+--- Page 1 ---
+UUID:0D1ACC76-910E-4243-A229-5F76B5A3299A TCGA-AN-A0AS-01A-PR Redacted TSS Patient ID: Case #: JB: Sex: Female Ethnicity (Race): Cancer Sample Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma Date of Procurement Anatomic Site: Left Breast Tumor location: Primary Tissue Specification: Tumor Specimen Matrix: Tissue Specimen Format: Frozen Container: cryomold Type of Procurement: Radical mastectomy Grade: 2 T Stage:2 N Stage: 2a M Stage: 0 Treatment: none Treatment Details: n/a.  Normal Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw. Matrix: Blood Specimen Format: frozen Container: tube Date of Procurement: 1c0-0-3 ca cinmn,hifiIt^ahng duct,Nos 85o0f3 Sife: brast, Nos. C5v.7 lw
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diff --git a/output/text/db50f1f8-fb16-45ba-ae93-5780028a532f.txt b/output/text/db50f1f8-fb16-45ba-ae93-5780028a532f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c6e44ff3ac308edfde66f673b399174d0a8e05b9
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+
+--- Page 1 ---
+1Cs-0-3 Carcioma, mfityrs#Ng 1obul, NUs 852Of3 Path Sif :Brsst, - c50.5 119/11 CQCF Sit: Busot, Nos c5o.9 Diagnosis: Well-differentiated invasive lobular carcinoma of the right.breast measuring up to 3.3 cm with circunscribed infiltration into the dorsal resection margin in the main preparation and with tumor-free follow-up dorsal resection material (thus tumor-free dorsal margin of at least 1.2 cm). Minimum margin 0.5 cm at 3 o'clock and carcinoma-free follow-up resection material at 3 o'clock with moderate mammary fibrosis and focal intraductal hyperplasia without atypia. Further minimum cranial and caudal margins > 1.2 cm. No invasion of lymph vessels. Fifteen Fifteen right axillary lymph nodes free of metastases with pre-existing lymphatic hyperplasia and pre-existing slight scarring in isolated larger lymph nodes. Tumor classification: M-8500/3, G 1, pT 2, L 0, V 0, pN 0 (0/15), pMX, R 0. Stage II a UUID:6443B16E-E6D9-4A1D-B950-BEEC7BAEDBBE TCGA-A8-A0A2-01A-PR Redacted
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diff --git a/output/text/db67bb7f-3262-4f49-96f2-2ff96a4461da.txt b/output/text/db67bb7f-3262-4f49-96f2-2ff96a4461da.txt
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index 0000000000000000000000000000000000000000..b5950c69f7e39f26234d7fc353e0d2be4dafaf28
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+
+--- Page 1 ---
+LCD O  UUID:4630A897-45DC-4122-BB86-A2943FE27CEA eureurton rex , ,shepatocellular AOS TCGA-MI-A75I-01A-PR Redacted 817013 Ste ouer CQQO SURGICAL PATHOLOGY w 8|3|13 MEDICAL RECORD SURGICAL PATHOLOGY PATHOLOGY REPORT Laboratory: Accession No. Subm itted by: Date obtained: Specimen (Received LEFT LATERAL RESECTOMY LIVER BRIEF CLINICAL HISTORY: PREOPERATIVE DIAGNOSIS: Hepatocellular carcinoma OPERATIVE FINDINGS: POSTOPERATIVE DIAGNOSIS: Surgeon/physician: PATHOLOGY REPORT Laboratory: Accession No. GROSS DESCRIPTION: The specimen consists of a 153 gram, 15.2 x 7.1 x 3.5 cm, segment of liver displaying a tan-red, granular resection margin with multiple. staples and clips.  The resection margin is inked black. The overlying capsule is tan-pink to purpie, and granular with abundant. nodularity. The capsular aspect is inked blue. The specimen is serially sectioned to reveal a 5.3 x 5.2 x 4.8 cm, tan-yellow to white,  granular, nodular mass that is 1.3 cm from the liver resection margin.  The mass is multifocal ranging from 0.2 to 5.8 cm in greatest dimensions. hepatic resection margin. The masses grossly extend to the overlying capsule. The uninvolved liver parenchyma is tan-yellow to brown and. unremarkable. Representative sections are submitted as follows: 1-4- largest mass to. resection margin; 5- smallest nodule to closest resection margin; 6-9-. nodules to overlying capsule; 10- largest mass with adjacent. uninvolved liver parenchyma. Please note a representative portion is taken for tissue bank. MICROSCOPIC EXAM DIAGNOSIS: Left lateral liver, resection: SPECIMEN: Liver PROCEDURE: Partial hepatectomy TUMOR SIZE: 5.3 x 5.2 x 4.8 cm TUMOR FOCALITY: Multiple HISTOLOGIC TyPE: Hepatocellular carcinoma HISTOLOGIC GRADE: G1 (well-differentiated) TUMOR ExTENsION: Tumor confined to liver MARGINS: Parenchymal margin uninvolved by invasive carcinoma (distance of invasive carcinoma from closest margin: 5 mm) LYMPH-VAsCULAR INVASION: Indeterminate PERINEURAL INVASION: Not identified PATHOLOGIC STAGING:
+
+--- Page 2 ---
+Primary Tumor: pT2. Regional Lymph Nodes: pNx. Distant Metastasis: Not applicable COMMENT : concurs with the diagnosis of malignancy. Physician was notified via. h gi13
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diff --git a/output/text/db6e784e-e6ca-47c0-9593-a76cb567f361.txt b/output/text/db6e784e-e6ca-47c0-9593-a76cb567f361.txt
new file mode 100644
index 0000000000000000000000000000000000000000..71cb28b88b0857ee5735f313f627e3dc8070ed1a
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Confidential UUID:AE058D5A-7249-44E5-87AA-663B07DA6A63 TCGA-T9-A92H-01A-PR Redacted Subject Number: Site ID:  Please complete ALL information with black ball point pen. Ensure information is legible.  Retain original and email/fax copy to Procured by: Sample Collection Date: Time Zone: Time of Tumor Sample Excision (24 hour clock): TUMOR-FROZEN & FRESH SAMPLES FROZEN SAmPLES BATCH SHIPPED (dry ice); FRESH TUMOR SAMPLE, IF COLLECTED, SHIPPED ON DAY OF COLLECTION Collect resected tumor in accordance with standard procedures. Weigh the sample and section off ~100mg. Frozen Tumor (Required)  Place this sample in the cryovial labeled Frozen Tumor sample and record the weight. Place the cryovial in a cane and then into the vapor phase dewar. Record the time placed in dewar. 270 Time placed in dewar: Weight of Tissue: mg (24 hour clock) H H (tissue weight must be  100mg)  N/A Fresh Tumor (Optional)  tube (sent separately). Place anv remainin.  Locate the "Fresh Tumor" label in the kit and affix to the 15m! tumor tissue into the 15ml conical tube containing Lot Number of  Time placed in (24 hour clock) (no min. weight specified) WHOLE BLOOD SAMPLE (Required) - BATCHED SHIPPED FROZEN (dr ice) Procured by: - Sample Collection Date: D.MMIM Time Zone:  Time of Blood Sample Collection HHMM (24 hour clock):  1-10ml EDTA tube. Fill tube completely and mix by gentle inversion at least 8-10 times. Freeze sample on dry ice or place in vapor phase dewar. Time placed in dry ice/dewar: HHMM (24 hour clock)  BASIC PATHOLOGICAL INFORMATION Sigmoicl Colon Odon CAnceR Source of Specimen: Clinical Diagnosis: (Ex. Right Lung) (Ex. Lung Cancer) Page 1 of 2 Confidential Valid from IcD0 3 lderotarentinss NoS d!4c13 Site: Sigmoed eslor C18.5 QP3h2w|14
+
+--- Page 2 ---
+Confidential Tissue/Blood Requisition Form Affix Label Here Or Write in Sample iD Site ID: Subject Number: c'Slides(Reguired)SLIDES BATCHED SHIPPED From the diagnostic FFPE block, cut 3 slides with one section.~ 4-5m on each slide. Label the frosted tip of the slide in pencil with the sample ID (located on the label at the top of this form). Record the ID number of the diagnostic. histology cassette and the number of slides. .H&E stain the slides and store in a slide mailer. Number of slides Cut Diagnostic Histology Cassette ID Refer to Study-Manualfor detailed specimen processing andshipp Specimen Collection Vesse! Transfer Tube Shipping Status Frozen Tumor* None Cryovial Same Day.-- Dry Ice. 1-10ml EDTA None Frozen Blood* Same Day -- Dry Ice Fresh Tumor None 15ml- Same Day -- Refrigerated Diagnostic slides* Histology Cassette SuperFrost Slides 5-Sllde Mailer-- Batch- ifybyEma devours mple DOJNOT RETURNEMPTYICONTAINTERST slides Confidential Valid from Page 2 of 2
+
+--- Page 3 ---
+Page 1 of 2 Surglcal Pathology Final Report Temporary Copyhrd Collected Final Diagnosis Superior hemorrhoidal lymph node: One (1) lymph node negative for neoplasm. Sigmoid colon, segmental resection: Adenocarcinoma. -Histologic grade: Moderately to poorly differentiated. -Tumor size: 6.3 cm in greatest dimension. -Tumor extension: Tumor penetrates muscularis propria and extends into pericolonic fat. -Lymph-vascular invasion: Definite lymph-vascular invasion is not identified. -Perineural invasion: Present, focal. -Surgical margins:  Proximal and distal margins negative for neoplasm. Radial margin negative for neoplasm. Mesenteric vascular margin negative for neoplasm. -Closest surgical margin: Proximal. Tumor comes to within 5.3 cm. -Lymph nodes: Thirteen (13) of thirteen (13) lymph nodes negative for neoplasm (0/13). AJCC pathologic stage: pT3,N0 STAge eA IIA Geade 2-3 Clinical Information Colon cancer. Gross Description "A. Superior hemorrhoidal lymph node." Received is a 0.5 cm lymph node with attached fat. "A." all "B, Sigmoid colon." Received Is an 18.8 crn segment of colon with attached pericolonic fat. There is a stitch attached to one. end of the specimen which is designated as proximal. The proximal margin will be inked orange. There is a 6.3 x 5.8 cm full circumferential ulcerated mass on the mucosa which is 5.3 cm from the proximal margin. There is black ink on the radial margin adjacent to the mass. The mass grossly appears to extend through the ful thickness of the wall of the colon and to. involve the adjacent pericolonic fat. No other masses or lesions are grossly identified on the remaining mucosa. There is a. vascular pedicle identified on the per icolonic fat. The mass grossly appears to come within 3.8 cm of the pedicle. The margin of the pedicie will be shaved and submitted. On sectioning the pericolonic fat, there are 11 possible lymph nodes ranging from. 0.4-0.8 cm. *B1." proximal and distal margins and vascuiar pedicle margin; "82-B4," random sections mass; "B5." possible regional lymph node; "86." possible lymph nodes remaining pericolonic fat ary Tumor Site Discrepan ase is (circle)
\ No newline at end of file
diff --git a/output/text/db9e92e5-57c4-4bf4-b2d2-0394c101f441.txt b/output/text/db9e92e5-57c4-4bf4-b2d2-0394c101f441.txt
new file mode 100644
index 0000000000000000000000000000000000000000..27365758a5687f34e4f6c7a98a3d6312945da73a
--- /dev/null
+++ b/output/text/db9e92e5-57c4-4bf4-b2d2-0394c101f441.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:90F83655-038B-412C-91BD-84CC3A420104 TCGA-A7-A3IZ-01A-PR Redacted Final Surgical Pathology Report JCs-u- 3 i nicinom,mfi(tatng ,le bulx.Nvs Procedure: 8,5x0f3 Situ: hust,nos c5o.q Diagnosis A. Sentinel lymph node #1, excision: Rare isolated cytokeratin positive cells (pnoi+). j 0/8/n B. Right breast, resection:. Invasive lobular carcinoma, 2.6 cm, extending to involve the inferior. and lateral margins. Microscopic Description:. Microscopic examination performed. A.  Sentinel lymph nodes examined at multiple levels section and H&E. staining as well as immunohistochemistry for pan-keratin. NO metastasis is seen on H&E staining. On pancytokeratin stain there are. rare isolated cytokeratin positive cells (pnoi+). B.  The following template applies to the right breast: Invasive Carcinoma: Histologic type: Invasive lobular cancer Histologic grade: Overall grade: 2 Architectural score: 3 Nuclear score: 2 Mitotic score: 1 Greatest dimension (pT): 2.6 cm, pT2 Specimen margins: Positive, invasive cancer extends to the. inferior margin, (green ink) in B1 and B3 and the lateral margin, (yellow ink) B7 Vessel invasion: Not identified Calcification: Present Ductal carcinoma in situ: not identified Description of non-tumorous breast: Biopsy site changes Comments: None Prognostic markers: Previously performed Specimen A. Sentinel node #1 - Right breast(single long stitch lateral, double stitch anterior) Clinical Information Right breast cancer Gross Description A. Container A is labeled with the patient's name, medical record number and "sentinel node #1". The specimen container holds a single rubbery tan lymph node measuring 1.2 x 1 x 0.8 cm. It is bisected and. submitted in blocks Al and A2.
+
+--- Page 2 ---
+ Container B is labeled with the patient's name, medical record number and "right breast - single long lateral, double stitch anterior". The specimen is inked as follows blue - anterior; left. posterior; yellow inferior.  The specimen measurements are 8.7 x 7.5 x 5.2 cm in greatest dimensions. The specimen is serially sectioned. Near the inferior. lateral surgical margin there is than visible and measures 2.6 x 2.2 x 1.5 cm.  Biopsy site changes are evident.  This mass appears to extend close to the inferior margin. Tissue is obtained for tissue procurement.. Representative sections are submitted in B1-B14. UA sU p2j 8/11
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diff --git a/output/text/dbedcbde-51c6-4b6d-a625-ffb92026ea1a.txt b/output/text/dbedcbde-51c6-4b6d-a625-ffb92026ea1a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3ee4e1cedc881d778dec574a77948534a012f5b3
--- /dev/null
+++ b/output/text/dbedcbde-51c6-4b6d-a625-ffb92026ea1a.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:1CF3FA64-EAE6-4A18-9851-F5980A885371 CGA-AC-A2FK-01A-PR Redacted tyfrof, SURGICAL PATHOLOGY REPORT Patfent Name: Accession #: Med. Rec. #: Location: Billng Type: DOB: Service: Taken: Gender: Blllng #: Recelved: Physlclan(o): Reported: SpecImen(s) Received A: Right breast tissue B: Sentinel node #1 C: Sentinel node #2 D: Left breast tissue E: Sentinel node #3 Pathologic Diagnosis A. Right breast tissue, ihastectomy: Benign breast tissue with multipie intraductal paplllomas and proliferative tibrocystic change. B. Sentinel node #1: One lymph node positive for metastatlo lobuiar carclnoma. The deposit measures 1.5 cm In greatest dimension. Superficlal extranodal extenslon is present. C. Sentinel node #2: One lymph node posltive metastatic lobular carclnoma. The deposit measures 1.3 cm. Superficial extranodal extension is present. D. Left breast tissue: Histologlc Type: Invasve lobular oardinoma 1cs-0-3 Modifled B-R Grade: 2 Tubular score: 3 carrnona, mifitrating Nuclear score: 2 1obul, Nos 8520f3 Mitosis score: 1 Tumor Size: Greatest dimenslon: 3.4 cm Situ; brusot Nos c5O.9 Additional dimensions: 3 X 1.2 cm Margins of Invasive Carcinoma: Negative S ufof Invasive carcinoma is located: 1.8 cm away from the deep margin Lymphovascular Invasion: Absent Duotal Carcinoma In Situ: Absent Paget's Disease: Absent Distant Metastasis: Cannot be assessed Specimen Type: Mastectomy Tumor Laterality: Left Tumor Site: Upper outer quadrant: Lymph Node Sampling: Sentine! lymph nodes only ChanMax Final Reports Page 1 0f 3 Surgical Pathology Report - Page 1/3
+
+--- Page 2 ---
+Surgical Pathology Report Cornment: Small intraductal papillomas present. Hormone receptors were performed on previous specimen : E. Sentinel node #3: One lymph node posltive for metastatlc lobular carcinoma. The deposit  measures 1.2 cm in greatest dimension. Superticlal extranodal extension is present.. PATHOLOGIC STAGE: pT2, pNX, pMX All three nodes samp!ed are positive and, therefore, the nodal stage Is at least pN1a.. NOTE: Information on pathology stage and the operative procedure Is transmitted to this Institution's Cancer Registry as requlred for accreditation by the Commisslon on Cancer. Pathology stage is based solely upon the current tissue speclmen being evaluated  and does not Incorporate other relevant data. Pathology stage is only a component to be considered in determining the clinical stage and shouid not be contused with nor substituted for it. The exact operative procedure is avallable in the surgeon's operative report. Clinlcal History Breast carcinoma. Gross Descriptlon "A" - The specimen is received in formalin labeled "right breast". It consists of an unoriented mastectomy specimen without axillary tissue measuring 18 x 17.5 x 4 cm and welghing 719 grams. There is an. overlying tan-white ellipse of skin measuring 12.2 x 9 cm showing a slightly eccentric, wrinkled pale tan areola, measuring 4.5 x 4.5 cm. In the center of the areola, there is an everted pale tan soft nipple measuring 1 x 1 x 0.5 cm. There are grossly no biopsy sites or healed incislons on the skin surface. The deep margin is inked black and the specimen is serially sectioned to reveal lobulated fat interspersed with a moderate amount soft-to-firm pink-tan nonfatty breast tlssue. There are scattered pink-tan soft circumscribed nodules measuring up to 0.4 cm in diameter. Also noted are cysts tilled with brown fluid measuring up to 0.3 cm in diameter. There Is grossly no evldence of mallgnlty. Representative sections are submitted in seven cassettes. Block summary: "A1" - vertical sectlon of nipple; *A2" - cross section of nipple; "A3" - tissue underlying the nipple; "A4 -"A7" - tlssue and nodules from each quadrant with the cyst Included in cassette "4". The specimen Is revlewed with. "B" - The specimen Is received in formalin labeled "sontinel node #1". It consists of a flrm pink-tan lymph. node and attached fat measuring overall 1.5 x 1 x 0.2 cm. The specimen is bisected and totally submitted in cassette "B". "C" - The specimen is received in formalin labeled "sentinel node #2". It conslsts of a pink-tan lymph node with attached fat measuring overall 1.3 x 0.8 x 0.6 cm. The speclmen is bisected and totally submitted in cassette "C". "D" - The specimen is received In formalin labeied "left breast". It consists of an unoriented mastectomy. specimen without axillary tissue measuring 20 x 17 x 4 cm and weighing 744 grams. There is an overlying tan-white ellpse of skin measuring 11.5 x 8 cm showing a slightly eccentric, wrinkled pale tan areola, measuring 4.5 x 4.5 cm. In the center of the areola, there is an everted pale tan soft nipple measuring 1 x 1 x 0.5 cm. There are grossly no blopsy sites or healed incisions on the skin surface. However, a papule is identifled 0.3 cm from the nearest margin of the skin ellipse, measuring 0.4 x 0.3 cm. The deep margin is inked black and the specimen Is serially sectloned to reveal a firm pale pink-tan mass which appears to Page 2 of 3 Surgical Pathology Report - Page 2/
+
+--- Page 3 ---
+Surgical Pathology Report. be within the upper outer quadrant measuring 3.4 x 3 x 1.2 cm. The mass comes to within 1.8 cm of the deep margin and 1 cm of the nearest superticlal margin (inked blue). The mass comes to within 3.2 cm of. the nipple. The deep margin is inked black and the specimen is serially sectioned to reveal lobulated fat interspersed with a moderate amount soft-to-firm plnk-tan nonfatty breast tissue. The tumor shows. adjacent linear and focal areas of Induration extending predominantly lateral and medial. No lymph nodes are grossly identified at the axillary margin. Representative sections are submitted in 12 cassettes. Block. summary: "D1" - vertical section of nipple; *D2* - cross section of nlpple; *D3" - tumor and nearest superficial margin; "D4" - tumor and nearest deep margin; "D5" - tumor away from the surglcal margin; "D6". and "D7" - irregular firm tissue approximately 1.5 cm medial to the tumor within the upper inner quadrant,. "D8" and "Dg" - Irregularly frm tissue within the upper outer quadrant lateral to the tumor, "D10" - lower Inner quadrant; "D11" - lower outer quadrant; "D12* - tissue underlying the nipple. The specimen Is. roviewed with 1. "E" - The specimen is received in formalin labeled "sentinel node #3". It consists of a tan-yellow portion of. fatty tissue measuring 2 x 1.5 x 0.6 cm. Sectioning reveals a pink-tan lymph node measuring 1.7 x 0.6 x 0.4 cm. the lymph node is totally submltted in cassette "E"..  Microscoplc Description Microscopic examinatlon has been performed on all slides. The pathologlc diagnos!s encompasses the essential microscopic findings of this case.. ChantMex Final Reportsd Pago 3 ol 3. Surgical Pathology Report - Page 3/'3 ge 11
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diff --git a/output/text/dc286dcf-24c8-4988-b9ee-63a44386865a.txt b/output/text/dc286dcf-24c8-4988-b9ee-63a44386865a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b9a074081fd04196896d45af2d016202e4a3ca67
--- /dev/null
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+
+--- Page 1 ---
+UUID:AAF32BB7-716A-4C0E-AE7E-04F6A5BF5628 Redacted Final Diagnosis DISQUALI east, left, simple mastectomy: Infiltrating ductal carcinoma, Nottingham grade II (of III), forming a 1.9 x 1.2 x 1.0 cm mass in ne superior breast (AJCC pT1c). A minor component of ductal carcinoma in situ, intermediate nuclear grade, is also present. Surgical resection margins are negative for tumor. The nearest (deep) margin is free by 0.2 cm. Lymph nodes, left axillary sentinel, excision: Multiple (3) left axillary sentinel lymph nodes are negative for tumor. Lymph nodes No.1, and No.2A contain no blue dye, lymph node No.2B contains blue dye. Immunohistochemical cytokeratin stain was  performed on the paraffin embedded sentinel lymph node tissue and confirms the H&E impression. Lymph node, left axillary, excision: A single left axillary lymph node is negative for tumor (AJCC pN0) Her-2/NEU analysis has been ordered on paraffin embedded tissue. 1cs-0-3 carcinomn, mfilrnatinj oluct, Nos85o0f3 Sin. brest Nos c50.9 lw 4/25/
\ No newline at end of file
diff --git a/output/text/dc3ba3d8-26b9-40b9-a482-860f2af140fb.txt b/output/text/dc3ba3d8-26b9-40b9-a482-860f2af140fb.txt
new file mode 100644
index 0000000000000000000000000000000000000000..baff7657a6ccb03cbdec403b0094d2d367172e89
--- /dev/null
+++ b/output/text/dc3ba3d8-26b9-40b9-a482-860f2af140fb.txt
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+
+--- Page 1 ---
+FINAL DIAGNOSIS: KIdney and adrenal Gland, Left, radical nephrectomy- KIDNEY: A. REnal CElL CaRcinOma, CLEar (convenTional) CeLl Type, fUrman GraDe 3-4 (3.2 Cm) (see comment). B. ALL SURGICAL MARGINS ARE FREE OF CARCINOMA. C. RENAL VEIN IS FREE OF CARCINOMA. THE CARCINOMA DOES NOT EXTEND BEYOND THE RENAL CAPSULE. E. TNM staging = pT1a Nx Mx. ADRENAL GLAND: A. ADRENALCORTICALADENOMA,3.5 x 2.8 CM (see comment) NO EVIDENCE OF MALIGNANCY. COMMENT: The following immunohistochemical stains were performed on a section of the renal tumor (slide D), and the adrena cortical adenoma (slide I), with the following results; Vimentin; negative in kidney, negative in adrenal Cytokeratin CAM 5.2; positive in kidney, negative in adrenal Cytokeratin AE1/AE3; positive in kidney, negative in adrenal EmA; positive in kidney, negative in adrenal Inhibin; negative in kidney, positive in adrena!  Melan-A; negative in kidney, positive in adrenal CD-10; positive in kidney, positive in adrenal CD-34; negative in kidney, negative in adrenal (positive in background vessels in both). The above immunohistochemical profile confirms these two neoplasms to be separate, i.e. the adrenal mass is not a metastasis of the renal cell carcinoma.
+
+--- Page 2 ---
+SynOpTiC - prImary KIDney/reNal PELVIS/UrEtEr TumORS Side: #2 1. Right 2. Left Location: #1 1. Kidney (parenchyma - cortex/medulla) 3. Ureter 2. Kidney (pelvis) 4.  Kidney and ureter C. Procedure: #3 1. Partial nephrectomy. 4. Ureterectomy 2. Simple nephrectomy 5. Other 3. Radical nephrectomy D. Size of neoplasm (maximum dimension; if multicentric, size of largest mass): # 3.2cm E. Type of malignant neopiasm: #1 1.  Renal cell carcinoma, clear cell type 11. Urothelial carcinoma, small cell/neuroendocrine (includes non-papillary granular cell RCC) carcinoma 2. Renal cell carcinoma, chromophil cell type 12. Urothelial carcinoma, mixed (papillary RCC, no clear cell component) 3.  Renal cell carcinoma, chromophobe cell type 13. Juxtaglomerular cell tumor  Renal cell carcinoma, oncocytic 14. Wilms'tumor 5. Renal cell carcinoma, sarcomatoid 15. Rhabdoid tumor 6. Collecting duct carcinoma 16. Clear cell sarcoma. 7. Urothelial carcinoma, TCCa 17. Congenital mesoblastic nephroma (non-invasive) 8. Urothelial carcinoma, TcCa 18. Sarcoma (non-clear cell) (invasive  in-situ) 9. Urothelial carcinoma, squarnous carcinoma 19. Lymphoma/leukemia 10. Urothelial carcinoma, adenocarcinoma 20. Other F.  Histologic grade F1. Fuhrman grade (for RCC; grades 1-4): #3/4 F2. Asn grade (grade 1-4): # F3. WHO grade (grade 1-3): # (for TCCa) F4. 1. LMP 2. LG 3. HG F5. Other malignant neoplasms (grades 1-3): # G. Non-neoplastic and other conditions: #/# /#/# 1. Glomerulopathy 2. Interstitial nephritis 3. Pyelonephritis 4. Nephrolithiasis 5. Papillary necrosis 6. Chronic parenchymal disease 7. Other H.  Margins of resection: #2 1. Positive 2. Negative .  Mitotic activity: # per 10 high power fields J. Angiolymphatic invasion J1. Macroscopic (e.g., renal vein thrombus): #2 1. Positive 2. Negative J2. Microscopic: #2 1. Positive 2. Negative K. Number of positive lymph nodes: # L. Total number of lymph nodes examined:# M. Extracapsular spread of lymph node metastases: #. 1. Yes 2. No N. Adrenal gland: N1. Present #1 1. Yes 2.No N2. Involvement by renal neoplasm: #2 1. Yes 2. No 3. Not Applicable N3. Other adrenal pathology:1 # 1. Yes 2.No 3. Not applicable O. TNM stage: T#1a Nx # M #x
\ No newline at end of file
diff --git a/output/text/dc6c7fd6-3e70-4605-a2f5-9f45b016ce53.txt b/output/text/dc6c7fd6-3e70-4605-a2f5-9f45b016ce53.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c957486e9e637e4fd35d0856c6ae05dad00727aa
--- /dev/null
+++ b/output/text/dc6c7fd6-3e70-4605-a2f5-9f45b016ce53.txt
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+
+--- Page 1 ---
+FINAL DIAGNOSIS: Part 1: LEft-BreaSt, Segmental bIOpSy --  INVASIVE DuctAL CARCiNOMA, nOTTINghAm GRADE 7/9 (NUCLEI 3, TUBULeS 2, mITOSES 2) WITh fOCi OF MICRO PAPILLARY FEATURES.(See comments). B. MICRO PAPILLARY CARCINOMA ACCOUNT TO ABOUT 10 % OF THE TUMOR MASS c. TumOR SiZE 2.1 X 1.8 X 1.3 Cm. D. 5% OF THE TUMOR MASS, PRESENT ADJACENT AND ADMIXED WITH THE INVASIVE CARCINOMA E.  NO PROMINENT ANGIOLYMPHATIC INVASION.E F.  MARGINS ARE FREE OF INVASIVE AND IN SITU CARCINOMA; CLOSEST MARGIN iS POSTERIOR MARGIN WHiCh IS 1Mm FROM THe TUMOR. G. FIBROCYSTIC CHANGES WITH DUCTAL EPITHELIAL HYPERPLASIA. H.  MICROCALCiFICATIONS PRESENT IN BENIGN EPITHELIUM AND ARTERIAL WALL. ESTROGeN RECEPTOR POS!TIVE, PROGESTERONE RECEPTOR POSITIVE AND hER-2.nEU NEGATIVe (1+) Part 2: LEft AXILLARy DISsecTiOn COntenTS, DiSsectiON - A.  One of seventeen lymph nodes with metastatic tumor (1/17). B.  THE METASTATIC CARCINOMA IN THE LYMPH NODE MEASURED 1.2X0.8 CM WITH EXTRACAPSULAR Spread about. 1cD-0-3 Part 3: Left Breast, new deep margin, Left Segmental mastectomy -  SKELETAl MUSCLE AND FIBROADIPOSE TISSUE, fREE OF TUmOR. Cavikomk, mj{trutwg cuhl, nes 8500/3 CASE SYNOPSIS: SiH:busst,Nss c5o.9 3/3/1 h SYNOPTIC - PRIMARY iNVASIVE CARCINOMA OF BREASTE LATERALITY: Left PROceDure: Segmental LOcAtIOn: Not specified SIZE OF TUMOR:  maximum dimension invasive component: 2 cm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI:S Yes TUmOR AgGrEgATE SIzE: Sum of the sizes of multiple invasive tumors: 2.1 cm TUMOR TYPE (invasive component): Ductal adenocarcinoma, NOs, Other Type(s): micropapillary NOTTINGHAM SCORE: Nuclear grade: 3 Tubule formation: 2 Mitotic activity score: 2 Total Nottingham score: 7 Nottingham grade (1, 2, 3): 2 ANGIOLYMPHATIC INVASION: No DERMAL LYMPHATIC INVASION: Not applicable CALCIFICATION: Yes, benign zones TUMOR TYPE, iN SITU: Solid, DCis admixed with invasive carcinoma, Percent of tumor occupied by in situ component: 5 % SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:E  No Distance of invasive tumor to closest margin: 3 mm SURG MARGINS INVOLVED BY IN SITU COMPONENT:E No Distance of in situ disease to closest margin: 13 mm Paget's DiSeaSE Of nIpplE: No LymPh NODES POSITiVE: UUID: CE32A294-10FC-4DBA-A779-FAEEBE677D38 1 LyMPH nODES EXAMINED: TCGA-BH-A0E7-01A-PR 17 Redacted METHOD(S) OF LYMPH NODE EXAMINATION: H/E stain SENTINEL NODE METASTASIS: No Only keratin positive Cells are present:. No SIZE OF NODAL METASTASES: Diameter of largest lymph node metastasis: 10 mm Lymph nODe metAStASIS(-ES) wIth eXtrACApsULAR EXTensiON: Yes METASTASES TO IPSILATERAL iNTERNAL MAMMARY LyMPH NODE (IF APPLiCABLE): No SKIN INVOLVED (ULCERATiON): No NON-NEOPLASTIC BREAST TISSUE: FCD t stage, pathologic: pT2 N STAgE, PAthOlOgIC: pN1 m STage, pathOlOgIC: pMX ESTROGEN RECEPTORS: positive PROGESTERONE RECEPTORS: positive HER2/NEU: zero or 1+
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diff --git a/output/text/dc7cba72-d677-4846-a2f0-b7267fd91521.txt b/output/text/dc7cba72-d677-4846-a2f0-b7267fd91521.txt
new file mode 100644
index 0000000000000000000000000000000000000000..93f0ccb052e754f67c6c974b18c6918293d932e5
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+
+--- Page 1 ---
+UUID:4C9C9D24-07E1-478E-8034-F946935768020 TCGA-AN-A0XN-01A-PR Redacted TSS Patient ID: Case #: ' DOB: Sex: Female Ethnicity (Race): . Cancer Sample Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma Date of Procurement: -Anatomic Site: Breast Tumor location: Primary Tissue Specification: Tumor Specimen Matrix: Tissue Specimen Format: OCT Container: block Type of Procurement: surgery Grade: 2 T Stage: 2 N Stage: 1 M Stage: 0 Treatinent: none Treatment Details: n/a Normal Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw Matrix: Blood Specimen Format: frozen Container: tube Date of Procurement 1cD-0-3 carciiomu vi filtraHing iluct,Nos 95ci/3 Sif: breast, Ncs c50.9
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diff --git a/output/text/dc7f4144-0fdb-42c0-9d62-ec345b0b1b2b.txt b/output/text/dc7f4144-0fdb-42c0-9d62-ec345b0b1b2b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2eaed4b07d573fce18cbaae3a022321e4e0bf050
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Colonic resection specimen (sigmoid) with a colon carcinoma of the histological type of a moderately differentiated adenocarcinoma, measuring 3 cm in its largest diameter and extending to a maximum of 11 cm from the resection margin. Invasive tumor spread to the level of the muscularis propria. Oral and aboral margins tumor-free. Ten mesocolic lymph nodes tumor-free and with uncharacteristically reactive changes.. Tumor stage therefore pT2 pn0 (0/10) L0 V0; G2 A further lymph node preparation was performed subsequently after special fixation.. A further seven very small lymph nodes were detected as a result. Histologically the lymph nodes are tumor-free. Lymph node status therefore pN0 (0/17)
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diff --git a/output/text/dc817ba5-d216-4463-892d-c94c8a9757bf.txt b/output/text/dc817ba5-d216-4463-892d-c94c8a9757bf.txt
new file mode 100644
index 0000000000000000000000000000000000000000..538200668e29b27e15ae8b4d45b14b6d6fa3dac1
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+
+--- Page 1 ---
+UUID:6342557E-F0C7-499E-8726-6FF0533AE95F tcgA-ts-a70y-01a-pr Redacted Date Printed: Date Collected : Date Received: Age:  years Sex: Male Accession No: Physician: Copy to: SurgicalPatnology Report CSCE TD O 3 Meostheli@mo, lpithelisol N6S 9052/3 patt Clinical Information Nesstheborna... buphses year old male with mesothelioma; Pleurectomy, PDT 9653/3 S: Yua NoS Final Diagnosis C38.4 1. pReVIOUS bIOPSy SITE: Fragment ot skin showing foci of foreign body giant cell reaction to talc particles within the superiacial and deep dermis. Negative for malignancy. 2. RighT RIB: Benign lamellar bone containing unremarkable bone marrow elements.. Asdherent striated muscle and fibroadipose tissue. Negative tor malignancy.. 3. INTERNAL MAMMARY NODE: One lymph node, positive tor metastatic malignant mesothelioma (1/1). 4. PERICARDIAL LN FAT: Four ot six lymph nodes, positive for metastatic malignant mesothelioma (4/6).  Separate fragments of fibroadipose tissue containing nodular aggregate of malignant mesothelioma also identitied. 5. MAJOR FISSURE: Alveolar lung parenchyma with a focus of malignant mesothelioma.. 6. POSTERIOR INTERCOSTAL NODE: Seven of seven lymph nodes, positive tor metastatic malignant mesothelioma (7r7). Extranodal tumor extension also noted. 7. LUNG IMPLANT: Nodular toci of malignant mesothelioma within the visceral pleura.. Tumor also involves the underlying lung parenchyma.. Separate fragments ot tibroadipose tissue showing foci of mmalignant mesothelioma with adjacent talc granulomas. Foci of lymphovascular invasion also noted. 8. LEVEL 7: Nine of of nine tragments of lymph node, positive for metastatic malignant mesothelioma. 9. LEVEL 9: Five ot five lymph nodes, positive for metastatic malignant mesothelioma (5/5). Nam MRN. Page l of 7
+
+--- Page 2 ---
+Name: Date Printed: MRN: Date Collected Date Received: Aae: 'ears Sex: Male Accesslon No Loc.: Physician: Copy to: surgical PathologyRanor! 10.LEVEL 8: Fragments of fibroadipose tissue and blood clot.. Scattered detached clusters of malignant mesothelioma noted. No lymph nodes identified. 11.LEVEL 10: Two of two lymph nodes, positive for metastatic rnalignant mesothelioma (2/2) 12. HILAR NODE: Two ot 4 lymph nodes, positive for metastatic malignant mesothelioma (2/4) 13. LEVEL 4: Three of 3 lymph nodes, positive for metastatic malignant mesothelioma (3/3).. 14. LEVEL 2: Blood clot, fibroadipose tissue and striated muscle containing a single detached cluster of malignant mesothelioma. 15. SUPERIOR MAMMARY NODE: Fragments of lymph node, no tumor.. 16. ANTERIOR HILAR NODE One lymph node, positive for metastatic malignant mesothelioma (1/1). 17. POSTERIOR HILAR NODE: One lymph node, positive for metastatic malignant mesothelioma (1/1). 18. PHRENIC NODE: Five of 5 lymph nodes positive for metastatic malignant mesothelioma (5/5). Extranodal tumor extension also noted.. 19. DIAPHRAGM: Fragments of fibroadipose tissue and striated muscle showing foci of malignant mesothelioma.. Foci of lymphovascular invasion also noted.. 20. PERIESOPHAGEAL LN: Nine of ten lymph nodes, positive for metastatic malignant mesothelioma (9/10).. Extranudal tumor extension also noted.. 21. PERIAORTIC NODE: Fragments of benign fibroadipose tissue and striated muscle. No lymph nodes are identified. Name Page 2 of 7 MRN
+
+--- Page 3 ---
+Name Date Printed. MRN: Date Collected : Date Received: DOE Age: years Sex: Male Accession No Loc.:  Physican: Copy to: Syrgfca Patn00gy Reporl 22. ADD. DIAPHRAGM: Fragments ot fibroadipose tissue and striated muscle showing foci of malignant mesothelioma.. 23. PERICARDIAL FAT: Fragments of benign fibroadipose tissue. Five lymph nodes, no tumor seen. 24. PHRENIC NERVE: Fibroadipose tissue containiing large nerve consistent with phrenic nerve.. A nodular tocus of malignant mesothelioma noted within the fibroadipose tissue without inavsion of nerve 25. AZYGOS VEIN: Fragments of tibroadipose tissue and large vessels. Negative for malignancy. 26. PERICARDIUM TISSUE: Fragments of tibroadipose tissue showing toci of malignant mesothelioma.. 27. PERICARDIUM/DIAPHRAGM: Malignant mesothelioma,biphasic type containing both epithelioid and sarcomatous component involving the mediastinal pleura, diaphragmatic pleura and a portion of lateral parietal pleura. Inked pericardial resection margin is free of tumor. Inked mediasternal fatty tissue margin is also free ot tumor. Inked diaphragmatic pleural resection margin is tree of tumor. Foci of lymphatic invasion also noted. 28. RADICAL PLEURECTOMY: Fragments of fibroadipose tissue showing foci of malignant mesothelioma,biphasic type containing both sarcomatous and epithelioid components,see comment. Foci of lympatic invasion present. Nodular foci of talc granulomas also noted. The case material was reviewed and the report verified by: MD (Electronic signature) Verification Date: Note Immunostains are performed on block 28A with adequate controls. Tumor cells are positive tor calretinin,CK5/6 and D2- 40. Tumor cells are negative for TTF-1 ,WT-1 and CEA. These features are consistent with malignant mesothelioma.. Name. Page 3 of 7 MRN
+
+--- Page 4 ---
+Name. Date Printed: MRN Date Collected Date Received: DOD Age: years Sex: Male Accession No:  Loc. Physician: Copy to: Surgical P a i n 0 1 o g y Raport See disclaimer: Disclaimer: The above in-vitro IHC tests may have used reagents labeled for IVD (In Vitro Diagnostic Use), IUO (Investigational Use Only) and/or RUO (Research Use Only) and have not been cleared or approved by the U.S Food and Drug Administration. However, the FDA has determined that such clearance or approval is not necessary for ASR class I tests intended to provide pathologists with adjunctive information to assist their morphologic evaluation. The tests using IUO or IUO reagents were developed and their performance characteristics were validated for diagnostic use by the This laboratory is regulated under the Clinical Laboratory Improvement Amendments ot 1988 (CLIA) as qualified to perform high complexity clinical tests. These Class I AsR tests are not intended to providediagnostic, prognostic, predictive or therapeutic information that are not directly contirmed by routine histopathologic internal or external control specimens.. Frozen Section Diagnosis FS1A & 1B: Previous biopsy site. Skin and underlying soft tissue with focal presence of foreign body giant cells and mild chronic inflammation. Called Received Reported FS2: Major fissure: Lung parenchyma with focal presence of malignant tumor.. Called  Received Reported F$3: Diaphraqm: Mesothelioma present. Called Received Reported Gross Description The specimen is received in 28 parts in a container labeled with the patient's name and medical record number.. Specimen #1 is designated "previous biopsy site" and consists of a yellow tan skin tragment with attached adipose tissue. The skin measures 4.5 x 1.5 cm in surface dimension and 2.5 cm in depth. The previous incision site is gray tan and measures 2.0 cm in length. the cut surface of subcutaneous tisuue is unremarkable. Representative section is submitted in three cassettes as follow: Cassette 1FS1A and 1FS1B fromtrozen section,Ic representative section of remaining skin. Specimen #2 is designated "right rib" and consists ot three gray tan rib fragments measuring from 5.0 cm to 6.5 cm in length and trom 1.0 cm to 1.8 cm in diameter. The specimen has a minimal amount of soft tissue attached measuring from less than 0.1 cm to 0.6 cm. Representative section is submitted in cassette 2A after fixation and decalcification. Name Page 4 of 7 MRN:
+
+--- Page 5 ---
+Name Date Printed: MRN: Date Collected Date Received: DOB years Sex: Male Accession No ge Loc.: Physician: Copy to: SurgicalpalhologyReport Specimen #3 is designated "internal mammary node" and consists of one yellow tan adipose tissue measuring 1.2 cm in greatest dimension. The specimen is bisected and submitted in cassette 3A. Specimen #4 is designated "pericardial lymph node and fat* and consists of two yellow tan to gray tan adipose tissue fragments measuring 1.5 and 4.5 cm in greatest dimension. The specimen is interlaced with multiple white tan to gray tan rubbery tirm lymph nodes measuring from 0.2 to 0.9 cn in greatest dimension. All lymph nodes and part of adipose tissue. is submitted in cassette 4A. Specimen #5 is designated "major fissure". The specimen is previously submitted for frozen section and consists of one purple tan to gray tan soft tissue fragments measuring 2.0 cm in greatest dimension. The specimen is submitted for. permanent histological examination in cassette 5AFS2. Specimen #6 is designated *posterior intercostal node" and consists of six gray tan to purple tan rubbery soft tissue fragments measuring 0.3 cm to 2.1 cm in greatest dimension. The specimen is submitted in cassettes 6A and 6B. Specimen #7 is designated "lung implant" and consists of one purple tan to gray tan rubbery soft tissue fragment measuring 5.2 cm in greatest dimension. The cut surtace of the specimen reveals multiple white tan to gray tan firm nodules measuring from 0.2 to 0.5 cm in greatest dimension. The specimen is submitted entirely in cassette 7A. Specimen #8 is designated level 7" and consists of multiple white tan to black tan rubbery soft tissue fragments measuring from 0.4 cm to 1.1 cm in greatest dimension. The specimen is submitted in cassette 8A.. Specimen #9 is designated "level 9" and consists of one white tan to purple tan rubbery soft tissue tragments measuring 3.5 cm in greatest dimension.The entire specimen is submitted in cassette 9A.. Specimen #10 is designated "level 8" and consists of one black tan to yellow tan soft tissue fragment measuring 1.6 cm in greatest dimension. The specimen is submitted in cassette 10A. Specimen #11 is designated "level 10" and consists of two yellow tan adipose tissue measuring 0.5 cm and 1.5 cm in greatest dimension. The specimen is interlaced with gray tan to black tan rubbery lymph nodes measuring from 0.5 to 1.5. cm in greatest dimension. The specimen is submitted in cassette 11A. Specinen #12 is designated "hilar node* and consists of two black tan rubbery soft tissue fragments measuring 0.8 and 1.7 cm in greatest dimension. The specimen is submitted in cassette 12A. Specimen #13 is designated "level 4" and consists of one yellow tan adipose tissue fragment measuring 3.0 cm in greatest dimension, interlaced with multiple white tan to purple tan rubbery lymph node measuring from 0.3 to 1.2 cm in greatest dimension. The lymph nodes are submitted in cassette 13A. Specimen #14. is designated 'level 2" and consists of one hemorrhagic soft tissue fragment measuring 3.5 cm in greatest dimension. Representative sections are submitted in cassettes 14A and 14B. Name. Page 5 of 7 MRN
+
+--- Page 6 ---
+Name Date Printed: MRN: Date Collected : Date Received: DOB years Sex: Male Accession No: Loc.:  Physician: Copy to: Surglcal PatnoIogy Reporl Specimen #15 is designated "superior mammary nodea and consists of one yellow tan to gray tan rubbery soft tissue fragment measuring 2.1 cm in greatest dimension. The specimen is submitted in cassette 15A. Specimen #16 is designated "anterior hilar node" and consists of one black tan rubbery soft tissue fragment measuring 0.4 cm in greatest dimension. The specimen is submitted in cassette 16A. Specimen #17 is designated "posterior hilar node" and consists ot one gray tan soft tissue fragment measuring 0.6 cm in greatest dimension. The specimen is submitted in cassette 17A.. Specimen #18 is designated *phrenic node" and consists of three yellow tan adipose tissue measuring from 0.5 to 1.9 cm in greatest dimension. The specimen is interlaced with multiple gray tan to purple tan rubbery lymph node measuring from 0.1 to 1.3 cm in greatest dimension. The lymph node is submitted in cassette 18A. Specimen #19 is designated "diaphragm" and consists of one gray tan to pink tan membranous tissue rneasuring 2.9 cm in greatest dimension. The specimen is submitted in cassette 19B. Part of the specimen is submitted for frozen section. The remaining tissue of the frozen section is submitted for permanent histological examination in cassette 19AFS3. Specimen #20 is designated "periesophageal LN" and consists ot multiple yellow tan to purple tan rubbery soft tissue fragments measuring from 0.9 to 3.2 cm in greatest dimension. The specimen is submitted in cassette 20A to 20C. Specimen #21 is designated "periaortic node" and consists of one yellow tan adipose tissue measuring 2.5 cm in greatest dirmension. The specimen is submitted in cassette 21A.. Specimen #22 is designated "additional diaphragm" and consists of multiple white tan to purple tan muscular membranous tissue fragments measuring 6.0 x 5.0 x 1.0 cm in aggregate.. The representative sections are submitted in cassettes 22A to 22C. Specimen #23 is designated "pericardial fat" and consists of one yellow tan lobulated adipose tissue measuring 4.5 x 2.5 x 1.2 cm. The specimen is interlaced with multiple small lymph nodes measuring from less than 0.1 cm to 0.4 cm in greatest dimension. Representative sections are submitted in cassette 23A. Specimen #24 is designated "phrenic nerve" and consists ot one gray tan to purple tan soit tissue tragment measuring 15.0 cm in length. The specimen is interlaced with one white tan nerve tissue. The specimen is submitted entirely in one cassette 24A. Specimen #25 is designated *azygos vein" and consists of one blue tan to purple tan blood vessel fragment measuring 5.3 cm in length and 0.5 cm in diameter. The outer surface of the vessel is smooth and glistening with minimal amount of adipose tissue attached. Representative section is submitted in cassette 25A. Specimen #26 is designated "pericardium tissue' and consists of one gray tan to purple tan soft tissue fragment measuring 3.2 cm in greatest dimension. The specimen is submitted in cassette 26A. Name Page 6 of 7 MRN:
+
+--- Page 7 ---
+Name Date Printed: Mrn: Date Collected : Date Received: ! DOE Age: years Sex: Male Accession No: Loc.:  Physician: Copy to: Surgical PalhologyReport  Specimen #27 is designated "pericardium/diaphragm" and consists of a cup shaped yellow tan soft tissue which contains. the thickened pleura from the diaphragmatic site,the mediasternal pericardial site and a portion of lateral parietal pleura. There is no lung tissue identified within the specimen, only the thickened pleura is present. The pericardial site was stitched and tnere is a pink tan membranous peridial soft tissue present which measures 5.0 cm in greatest dimension. The diaphragmatic pleura consistent of white to reddish muscle at the surgical margin. The stiched pericardial. membranous margin is inked blue, the mediasternal pleural fatty tissue margin is inked blue,the diaphragmatic pleura margin is in black.. The specimen is serially sectioned. The cut surface of soft tissue has diffuse intiltrated tumor nodules measuring from 0.5 up to 4.0 cm in thickness. The tumor involves all the pleuras. Representative sections are submitted as follows: 27A-27C Tumor with membranous inked pericardial margin. 27D-27E Tumor with inked mediasternal fat margin. 27F-27H Tumor with inked diaphragmatic pleural margin. Specimen #28 is designated *radical pleurectomy" and consists of multiple gray tan to pink tan nodular pleural tissue measuring 22.0 x 10.0 cm in aggregate. The thickness measures from 1.0 cm to 2.0 cm. The cut surtace of the. specimen reveals multiple white tan to gray tan nodules measuring from 0.2 cm to 2.5 cm in greatest dimension. Representative section is submitted in cassette 28A to 28D. Case reviewed with attending pathologist.. Dictated by and  dictated by Dictated by: Pathologist(s) Pw TSS dx dovupnr TC 6t Spicin, pte A Name Page 7 of 7 MRN: 913
+
+--- Page 8 ---
+Page 1 of 1 TCGA Pathologic Diagnosis Discrepancy Form 4.05  Study Subject ID: Person ID: N/A Study/Site: TCGA Mesothelioma - Age: N/A Event:  PathDiscrepancy Date of Birth: Interviewer: Sex: M Tumor Identifier Provided on Initial Case Provide the tumor identifier documented on the initial case quality Quality Control Form control form for this case.. Pathologic Diagnosis Provided on Biphasic Provide the diagnosis/ histologic subtype(s) documented on the initial pathology report Initial Pathology Report. for this case. If the histology for this case is mixed, provide all listed subtypes. Histologic features of the sample provided for Epithelioid Provide the histologic features selected on the TCGA Case Quality TCGA, as reflected on the CQCF Control Form completed for this case. Discrepancy between Pathology Report and Case Quality Control Form. Provide the reason for the discrepancy Submitted Provide a reason describing why the diagnosis on the initial between the pathology report and the TCGA specimen is. pathology report for this case is not consistent with the Case Quality Control Form Epethelioid diagnosis selected on the TCGA Case Quality Control Form. Name of Tss Reviewing Pathologist or Provide the name of the pathologist who reviewed'this. Biorepository Director case for TCGA.
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diff --git a/output/text/dc9f16d1-a384-4e33-a9c1-f49f50314913.txt b/output/text/dc9f16d1-a384-4e33-a9c1-f49f50314913.txt
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index 0000000000000000000000000000000000000000..75b2a991e97d5ea28009fb0e8e5a30d09539dfc5
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+
+--- Page 1 ---
+UUID:6958EEA8-8980-4B04-BB43-138097300F460 tcga-e1-a7ye-01a-pr Redacted Patient: Surgical Pathology: Fina! Surg Path CLINICAL HISTORY: Brain tumor left frontal anaplastic astrocytoma.. GROSS EXAMINATION: A. "Brain tumor (AFl-2)", received fresh. A 6.5 x 5.0 x 3.0 cm resection of brain tissue is received. Representative tissue is frozen as AFl-2, the frozen section remnants are submitted in respective blocks A1-2. Additional representative sections are submitted as A3-8.. INTRA OPERATIVE CONSULTATION: A. "Brain tumor":AFl- gliosis, atypical cells.  AF2- glioblastoma MICROSCOPIC EXAMINATION: Permanent sections reveal a highly cellular pleomorphic population of astrocytes consistent with a high grade glioma. The area interpreted as necrosis on frozen section as AF2 actually represents an area of hemorrhage as seen in permanent sections.. DIAGNOSIS: A. "BRAIN TUMOR": ANAPLASTIC ASTROCYTOMA (WHO GRADE III). SEE COMMENT. Comment: Hemorrage due to surgical trauma, present in permanent section on block A2 was interpreted as frank necrosis at frozen section. No frank. necrosis is appreciable in any of the permanent sections, making this an anaplastic astrocytoma. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es). Electronically signed: I@03 5 8/s/4 Printed by: 1 of 1
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diff --git a/output/text/dca0da49-23c8-4c3a-ba06-4eaa82d6259a.txt b/output/text/dca0da49-23c8-4c3a-ba06-4eaa82d6259a.txt
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index 0000000000000000000000000000000000000000..9900bb08c1db2e032ddba34a79d72fd1cd229506
--- /dev/null
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+
+--- Page 1 ---
+I (First Tumor) Tumor Site: Ascending Colon Date of Cancer Sample Procurement: Histology: Adenocarcinoma Description of other histology: Grade: Moderately Differentiated C Yes Mucinous: C No  Yes C Unknown (Focal)  Yes Signet Ring Feature:.  No C Yes r~ Unknown (Focal) Histologic Heterogeneity:  No r Yes C Unknown Host Response: None Crohn's like reaction.  None  Yes C Unknown Plasma cell rich stroma C No r Yes C Unknown  Expansile:  Unknown Growth Pattern:  Expansile ( Invasive and Invasive.. Inflammatory Bowel Disease 6 No ( Yes C Unknown Angiolymphatic Invasion: 6 No C Yes  Unknown Mutator Phenotype: C No 6 Yes r Unknown Number of Slides 1 C Yes Garland Necrosis present: 6 No r Yes C Unknown (Focal) TIL Cells / HPF .8 Pathologist Comment: serrated adenoma /cs-0-3 adinocaicininia muceius, N0s 8y80f3 Sith: ascnhiq cvlor C18.2 UUID: EDE93B1A-2535-4D48-9995-DD050CA8A5D7 TCGA-DM-A280-01A-PR Redacted h 5|3/n
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diff --git a/output/text/dcd4650f-07a2-4003-929e-9a68f65f63d4.txt b/output/text/dcd4650f-07a2-4003-929e-9a68f65f63d4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..18efed887c315e48ee07efcdc80f77868b02a27a
--- /dev/null
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+
+--- Page 1 ---
+IcD-0-3 C hrcinonu, nfi/f^atny duct, Nos 85o0/3 Sit: braot, Nos c50.9 4/33" OC#: TSS # Procurement Date: Laterality:Right, upper outer quadrant Path RepOrt:BREAST TISSUE CHECKLIST Specimen type: Lumpectomy Specimen size: Not specified. Tumor site: Upper outer quadrant Tumor size: 1.4 x 0 x 1.8 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinoma Histologic grade: Moderately differentiated Tumor extent: Not specified Lymph nodes: 1/10 positive for metastasis (Axillary 1/10) Extracapsular invasion of the lymph nodes: Not specified Margins: Uninvolved Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None UUID: 392524F7-8570-4047-A439-71FC15642DC8 TCGA-E9-A24A-01A-PR Redacted
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diff --git a/output/text/dcdf5cc9-9da3-4b09-8bb3-dbb0b2b3d777.txt b/output/text/dcdf5cc9-9da3-4b09-8bb3-dbb0b2b3d777.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b5feee4927b8aa153a0557eaefb66201725782b6
--- /dev/null
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+
+--- Page 1 ---
+SPECIMENS: A. LEFT RENAL MASS B. ADDITIONAL TUMOR C. LEFT RENAL FINAL MARGIN D. FINAL RANDOM MARGIN E. FAT OVERLYING KIDNEY-LEFT SPECIMEN(S): A. LEFT RENAL MASS B. ADDITIONAL TUMOR C. LEFT RENAL FINAL MARGIN D. FINAL RANDOM MARGIN E. FAT OVERLYING KIDNEY-LEFT CLINICAL HISTORY  None given INTRAOPERATIVE CONSULTATION DIAGNOSIS FSC/FSD- Negative for tumor by Dr. to Dr. at GROSS DESCRIPTION: A. LEFT RENAL MASS Received fresh is a piece of yellow-tan soft tissue weighing 13 g and measuring 3.7 x 2.8 x 2 cm. There is a suture designating the site of additional tumor resection. The indicated surface is inked blue and the opposite surface is inked black. The specimen is bisected; there is a well-circumscribed gold-tan mass measuring 1.5 x 1.3 x 1.2 cm which is located adjacent to the tumor resection margin. The mass is hemorrhagic and necrotic. Portion is submitted for procurement. The adjacent fat is unremarkable.. The specimen is submitted entirely in cassettes A1-A8. B. ADDITIONAL TUMOR-LEFT RENAL Received in formalin is a piece of brown-tan tissue measuring 1.7 x 1.5 x 1.2 cm. There is a area white-. tan discoloration measuring 0.9 x 0.9 x 0.2 cm. The renal tissue is inked black. The specimen is serially sectioned and submitted entirely in cassettes B1-B2. C. LEFT RENAL FINAL MARGIN Received fresh are 3 small tan-red tissue fragments measuring 0.6 x 0.4 cm in aggregate. Submitted entirely for frozen section diagnosis in cassette FSC1. D. FINAL RANDOM MARGIN Received fresh are 4 tan tissue fragments measuring 0.8 x 0.5 cm in aggregate. Submitted entirely for frozen section diagnosis in cassette FSD1.. E. FAT OVERLYING KIDNEY-LEFT Received in formalin is an aggregate of yellow-tan adipose tissue measuring 20 x 14 x 4 cm. On sectioning, no masses, lesions, or areas of discoloration are identified. Representative sections are submitted in cassette E1-E3. DIAGNOSIS: A. KIDNEY, LEFT, PARTIAL NEPHRECTOMY: - RENAL CELL CARCINOMA, PAPILLARY TYPE, FUHRMAN GRADE 2 CONFINED TO KIDNEY. MEASURING 1.5 CM - RESECTION MARGINS NEGATIVE FOR TUMOR - SEE SYNOPTIC REPORT. B. KIDNEY, LEFT, ADDITIONAL TUMOR AND FINAL MARGIN, EXCISION: - PAPILLARY RENAL CELL CARCINOMA - MARGINS NEGATIVE FOR TUMOR. C. KIDNEY, LEFT, FINAL MARGIN, EXCISION: - FRAGMENTS OF RENAL PARENCHYMA, NO TUMOR SEEN. D. KIDNEY, LEFT FINAL RANDOM MARGIN, EXCISION: - FRAGMENTS OF RENAL PARENCHYMA, NO TUMOR SEEN
+
+--- Page 2 ---
+E. SOFT TISSUE, OVERLAYING LEFT KIDNEY, EXCISION: - FIBROADIPOSE TISSUE, NO TUMOR SEEN SYNOPTIC REPORT - KIDNEY (PARTIAL OR RADICAL) Specimen Type:  Partial nephrectomy. Without adrenal gland Laterality: Left Tumor Site: Not specified Focality:  Unifocal Tumor Size (largest tumor if multiple): Greatest dimension:. 1.5cm Macroscopic Extent of Tumor: Tumor limited to kidney WHO CLASSIFICATION Papillary renal cell carcinoma 8260/3 Histologic Grade (Fuhrman Nuclear Grade): G2: Nuclei slightly irregular, approximately 15 u; nucleoli evident Invasion of Vascular/Lymphatic: Absent Perinephric Tissue Invasion: Absent Margins:  Margins uninvolved by invasive carcinoma Adrenal Gland:. Not present Regional Lymph Nodes:  None sampled Additional Findings: None identified Pathological Staging (pTNM):  pT 1a N X M X PRE-OPERATIVE DIAGNOSIS: Left renal mass
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diff --git a/output/text/dd457ee1-3a6f-423c-bf3a-be96bc5a024b.txt b/output/text/dd457ee1-3a6f-423c-bf3a-be96bc5a024b.txt
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index 0000000000000000000000000000000000000000..f97c8630d8245c94f23fc1655525863339cd314d
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+This information is subject to all Federal and State laws regarding contidentiality and privacy and to the policies and procedures of  patient information. Any unauthorized use. disclosure, or reproduction of this information is strictly prohibited. regarding Anat Path Reports. * Final Report. ID0.3 Document Type: Anat Path Reoorts densearsinsms, dtis+ NOS Document Date: 8 500l3 Document Status: Auth (Verified) Document Title: Histoloav Sit: Pansirota l Performed By: CQ5.2 Verified By: Encounter info: A S 1/7/4 * Final Report * UUID:881F2828-DD95-4773-9ADE-734812598CED TCGA-RB-AA9M-01A-PR Redacted (Verified) Patient Name: Acc #: MrN: DOB: Age: Location: Gender: Collected: Client: Received: Submitting Reported: Phys: Final Surgical Pathology Report Final Pathologic Diagnosis A. pancreas and Spleen, Distal pancreatectomy and Splenectomy, (a1fs): - Invasive Ductal Adenocarcinoma, Pancreatobiliary type, poorly Differentiated. - Estimated tumor Size: 2.0 x 2.0 Cm. - PANCREATIC NECK MARGIN IS NEGATIVE. - metastatic Carcinoma in One Of nine Lymph nodes, 1/9. (0.2 CM FOCUS/NO EXTRANODAL EXTENSION). - VASCULAR SPACE INVASION PRESENT. - PERINeURAL InVASIOn PRESENT. - Spleen wIthout Diagnostic AbnormaLIty. - SEe SynOptIC REpORT. Electronicallv Sianed by , Pathologist Printed by: Printed on: Page 1 of 4 (Continued)
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+This information is subject to all Federal and State laws regarding confidentiality and privacy and to the policies and procedures of regarding  patient information. Any unauthorized use, disclosure, or reproduction of this information is strictly prohibited. Anat Path Reports * Final Report Assisted by: Synoptic Worksheet A. Distal pancreas, spleen (test for frozen margin on fhe staple line) Specimen: Tail of pancreas Spleen Procedure: Other: distal pancreatectomy and splenectomy Tumor Site: Pancreatic tail Tumor Size: Greatest dimension: 2.0 cm Additional dimension: 2.0 cm Histologic Type: Ductal adenocarcinoma Histologic Grade: G3: Poorly differentiated Microscopic Tumor Extension: Tumor is confined to pancreas Margins: Margins uninvolved by invasive carcinoma Distance of invasive carcinoma from closest margin: 10 mm Margtis uninvolved by carcinoma in situ. Treatment Effect: No prior treatment Lymph-Vascular Invasion: Indeterminate Perineural Invasion: Present TNM Descriptors: Not applicable Primary Tumor (pT): pT2: Tumor limited to the pancreas, more than 2 cm in greatest dimension Regional Lymph Nodes (pN): pN1: Regional lymph node metastasis. Number of lymph nodes examined: 1. Number of lymph nodes involved: 9. Distant Metastasis (pM): Not applicable Additional Pathologic Findings:  None identified Clinical History Distal pancreatectomy and splenectomy.. Specimen(s) Received A: Distal pancreas, spleen (test for frozen margin on fhe staple line) Gross Description The specimen is received fresh, labeled with the patient's name, medical record number and "distal pancreas, spleen; test frozen margin on the staple line" and consists of a 482.5 grams distal pancreatectomy and splenectomy specimen including pancreas (14.5 x 6.0 x 2.6 cm) and spleen (17.0 x 12.0 x 5.2 cm). The anterior aspect of the pancreas is unremarkable. The posterior aspect of the pancreas has two white, plaque-like discolorations (1.6 x 1.5 cm and 2.0 x 2.0 cm). The smaller discolored area is located 5.9 cm from the neck edge. The cut surface of the pancreas has a firm, white and focally hemorrhagic mass, 8.0 cm (proximal to distal) by 2.5 cm (anterior to posterior) by 2.4 cm (width). The mass is located 1.0 cm from the neck edge and occludes the pancreatic duct in this area. The Printed by: Printed on: Page 2 of 4 (Continued)
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+This information is subject to all Federal and State laws regarding confidentiality and privacy and to the policies and procedures of regarding patient information. Any unauthorized use, disclosure, or reproduction of this information is strictly prohibited. Anat Path Reports + Final Report  mass abuts both the anterior and posterior aspects and is continuous with the aforementioned plaque-like discoloration. The remaining cut surface of the pancreas is iobulated and unremarkable. The splenic capsule is intact and unremarkable. The cut surface of the spleen is unremarkable and uninvolved by mass. The splenic artery is uninvolved. yet adjacent to the mass. The neck margin is submitted for frozen section. Representative sections are submitted as stated below. Photographs are taken. Dictated by INK CODE: Blue -- anterior pancreas Black --posterior pancreas Orange -- neck edge- Green -- pancreatic duct lining CASSETTE SUMMARY: A1FS -- pancreatic neck margin A2 -- pancreatic neck edge, en face A3 -- most proximal edge of mass with pancreatic duct A4 -- mass with area of focal hemorrhage in closest relationship to anterior surface, with splenic artery A5 - representative sections of pancreas between white component of mass and plaque-like discoloration, with adjacent normal pancreas A6 -- mass at focal discoloration #1 A7 -- mass at focai discoloration #2 (most distal edge of mass) A8 -- representative spleen A9 -- hilar adipose tissue A10 -- five peripancreatic lymph nodes, intact A11- representative omentum Intraoperative Consult Diagnosis A1FS: DISTAL PANCREAS, SPLEEN (FROZEN SECTION): PANCREATIC NECK MARGIN, NEGATIVE FOR INVASIVE CARCINOMA. Frozen section results were communicated to the surgical team and were repeated back b: in at . out at Pathologist: Printed by: Page 3 of 4 Printed on: (Continued)
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+This information is subject to all Federal and State laws regarding confidentiality and privacy aid to the policies and procedures ot egarding  patient intormation. Any unauthorized use, disclosure, or reproduction of this information is strictly prohibited.. Anat Path Reports * Final Report Printed by: Page 4 of 4 Printed on: (End of Report) Ye
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diff --git a/output/text/dd4e5c27-115a-4452-9a68-64632185e035.txt b/output/text/dd4e5c27-115a-4452-9a68-64632185e035.txt
new file mode 100644
index 0000000000000000000000000000000000000000..66fa22a0e910e5bdc3295b825df5bb4391f68c26
--- /dev/null
+++ b/output/text/dd4e5c27-115a-4452-9a68-64632185e035.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UUID:4CD1A49C-2243-4F21-BF19-E86F069D431E TCGA-CC-A7IF-01A-PR Redacted trb APPROVED Form Revised Fax: Clinical Case Report ID o-3 (For Collection of Cancerous Tissue) CeeeironohejeatwrIsulo 8//3 Nbs Sut; slwier Q22.0 A/o(13 Informed Consent I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator. Signature Date Clinical Information GENERAL INFORMATION Date of Birth /mr Height Marital Status Race Temperature Gender Weight  Blooa Pressure Heart Rate Male  Female HISTORY OF PRESENT ILLNESS Chief Complaints: AbWounal Aj`n ) fev er.. Cnsti'patcn Symptoms: Weicht- loss Clinical Findings: Performance Scale (Karnofsky Score):  100 Asymptomatic  80-90 Symptomatic but Fully Ambulatory   60-70 Symptomatic, in bed less than 50% of day 40-50 Symptomatic, in bed more than 50% of day, but not bed ridden. 20-30 Bed Ridden CURRENT MEDICATIONS Drug Dose Route Frequency Date (mm/dd/yyyy) To To To 1 / To To
+
+--- Page 2 ---
+PAST MEDICAL HISTORY Diagnosis/Disease/Disorder/Intury Diagnosis Date Treatment Status OB/GYN HISTORY Menopausal Status Date of First Menses # of Pregnancies  Pre-menopausal  Peri-Menopausal Date of Last Menses # of Live Births  Post-menopausal Birth Control: Condom  Oral Contraceptive  IUD  Hormone Replacementd  Other: Therapy: SOCIAL HISTORY Occupation: Environmental Hazards: Smoking History Current Status TYPE  Packs/day Duration When Quit  nO Weldas YES (yrs) (2mths cxgn)(yr) Alcohol Consumption U Current Status TYPE Drinks/day Duration When Quit  YES  nO ys) hmaths ags ( Drug Use i Current Status TYPE Frequency Duration When Quit D YES NO (yrs) (yr) FAMILY MEDICAL HISTORY Relative Diagnosis Age of Diagnosis LAB DATA Test Result Date Test Result Date HIV TNegative  Positive: CEA  Negative  Positive: Hep B Negative  Positive: CA 15-3   Negative  Positive: Hep C P Negative  Positive: CA 19-9   Negative  Positive: AFP '  Negative  Positive: PSA   Negative  Positive: Other: Other: Negative  Positive:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+DIAGNOSTIC STUDIES Study. Results Date Ultrasound X-Ray CT x Ataxeus Ya Joud un te liyer: Endoscopy MRI Biopsy CLINICAL DIAGNOSIS Preoperative Clinical Dlagnosis R. lirer CernceA Locatlon of Suspected Involved Lymph Nodes. Location of Suspected Distant Metastasis Clinlcal Staging Date of Diagnosis T3 No mO Stage:I A- Treatment Information SURGICAL TREATMENT Procedure Date of Procedure. the. i oh Ieseetiun Primary Tumor Organ Detailed Locatlon Size Riaa! diuR 8 xZ x6 cm Extenslon of Tumord Lymph Nodes Description Location of Lymph Nodes # of Lymph Nodes. Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes. Distant Metastasis. Organ Detailed Location Size Surgical Staging T 3 Na. Mo Stage: T NEOADJUVENT THERAPY (Chemo, Radiation, Immumo, Hormonal, or Molecular) Drug/Treatment Dose Route Frequency Date (mm/dd/yyyy) To 1 1 To 1 To 1 To To f 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by: -- Date: Time... Preserved by: -.. Date: Time: SPECIMEN TYPE (# of samples provided) Frozen Paraffin Block  Blood/Serum/Plasms Slide Diseased Normal Diseased Normal Diseased Normal Diseased Normal 2 2 2  Time to LN2 Time to Formalin Time to LN2 min min min PATHOLOGICAL DESCRIPTION Primary Tumor Organ Size Extension of Tumor Distance to NAT Lemr 8x Zx 6 cm RistJ Iidce. 6 cm Lymph Nodes Locatlon # Examined # Metastasized Distant Metastasis Organ Detailed Location  Size Pathological Staging pT 3 No m c Stage: TILA Notes: 4
+
+--- Page 5 ---
+IR8 APPROVED Form Revisey Fax: ' Consolidated Pathology Diagnosis Cell Distribution + Structural Pattern Diffuse VStreaming + Mosaic  Storiform Necrosis Fibrosis  Lymphocytic Infiltration  Palisading Vascular Invasion Cstic Degeneration Clusterized K Bleeding  Alveolar Formation Myxoid Change Indian File  Psammoma/Calcification  Squamous + Adenomatous +  Sarcomatous  Squamoid Cell + Lymphomatous Glandular cell Round Cell Large Cell Spindle Cell Cell Stratification K  Fibroblast Small Cell Keratin Secretion Osteoblast  Desmosome  RS Cell/RS Like Intracyt. Vacuole Lipoblast Inflam. Cell Pear!  Gland formation Myoblast Plasma Cell Ceilular Differentiation:  Well  Moderate  Poor Nuclear Atypia: Aniso Nucleosis 0 1 11 III Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity Nuclear Grade: X Final Pathology Report Histological Diagnosis: eplts ce//iluk Cek lir dsrA  Grade: Comments: p107 prq87 D39d7D41o7 Date W 8136|13 INTEGRAIED REPORT OF FINDINGS BY COLLABORATORS AND 'ATHOLOGISTS Criterla Digwis Discrep Pmy or e Discre PAA Disrepanc Pricr Maignancy isto al/SychronouPrm Case is (circie: Date Reviewe
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diff --git a/output/text/dd5e4419-b27c-430a-ae5d-1f73ce58276c.txt b/output/text/dd5e4419-b27c-430a-ae5d-1f73ce58276c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c4589066cb9fd81b0a1aedb2ed958c799a092420
--- /dev/null
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@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+UUID:074223E9-5E1C-47E8-BE40-1C4442CAE9F0 PESOMAL DATA PRIVACY ACT OF 1974 TCGA-A2-A1FV-01A-PR Redacted SURGICAL PATHOLOGY REPORT Patient: FMP/SSN: Specimen #: DOB/Age/Sex: (Age: Race: Location: Taken: Physician(s) : Received: Reported: 1e8-0-3 SPECIMEN: Carcinom,m liltratng 1obulay Nos A: SENTINEL LYMPH NODE #1 B: LEFT AXILLARY TISSUE 8520/3 C: LEFT MASTECTOMY D: NEW INFERIOR MARGIN Sit: sreat, N0s c50.9. 1/25/ FINAL DIAGNOSIS: A. SENTINEL LYMPH NODE #1, BIOPSY: - ONE OF TWO LYMPH NODES WITH ISOLATED TUMOR CELLS (ITC) DETECTED BY CYTOKERATIN IMMUNOHISTOCHEMICAL STAINING, refer to part C. B. SOFT TISSUE, LEFT AXILLA, EXCISION:  BENIGN FIBROADIPOSE AND VASCULAR CONNECTIVE TISSUE WITH NERVE. - NO EVIDENCE OF LYMPH NODES - NEGATIVE FOR MALIGNANCY. C. .I, MASTECTOMY: i TYPE: INVASIVE LOBULAR CARCINOMA. HISTOLOGIC GRADE: GRADE 2, MODERATELY DIFFERENTIATED. NOTTINGHAM SCORE: 6 (Tubules= 3, Nuclei- 2, Mitoses= 1) TIr IZE (GREATEST DIMENSION): GREATER THAN 5.0 CM, See COmment.) ITE (QUADRANT): OUTER UPPER AND MID. 'YPE: INVASIVE LOBULAR CARCINOMA. .JLC :IC GRADE: GRADE 1, WELL DIFFERENTIATED. NOTTINGHAM SCORE: 5 (Tubules= 3, Nuclei- 1, Mitoses= 1) TUMOR SIZE (GREATEST DIMENSION): 0.3 CM, measured microsCopically. TUMOR SITE (QUADRANT): INNER UPPER. TUMOR FOCALITY: MULTIFOCAL. TUMOR NECROSIS: NOT IDENTIFIED. MICROCALCIFICATIONS: PRESENT; ASSOCIATED WITH INVASIVE AND IN SITU TUMOR AND ALSO NON-NEOPLASTIC TISSUE.  LYMPH-VASCULAR INVASION: PRESENT, slide C6.  MARGINS: NEGATIVE FOR MALIGNANCY. - DISTANCE OF INVASIVE TUMOR FROM NEAREST MARGIN = O.5 CM, DEEP. IN SITU COMPONENT: LOBULAR CARCINOMA IN SITU (LCIS).  DISTANCE OF LCIS FROM NEAREST MARGIN = LESS THAN O.1 CM, DEEP. LYMPH NODES: ONE OF TWO NODES WITH ISOLATED TUMOR CELLS.  NUMBER OF SENTINEL LYMPH NODES EXAMINED: 2 - NUMBER OF LYMPH NODES WITH MACROMETASTASES: 0 NUMBER OF LYMPH NODES WITH MICROMETASTASES: 0  NUMBER OF LYMPH NODES WITH ISOLATED TUMOR CELLS: 1  EXTRANODAL EXTENSION: NOT IDENTIFIED. Page 1 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 2 ---
+FOR OYYICIAL USE OWLYS AL DATA  PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Specimen #: Patient: FINAL DIAGNOSIS (continued) : NIPPLE/ SKIN INVOLVEMENT: NOT IDENTIFIED. ANCILLARy STUDIES (performed on core biopsy - ESTROGEN RECEPTORS: POSITIVE. PROGESTERONE RECEPTORS: POSITIVE. HER 2 NEU by IHC: NEGATIVE. -ADDITIONAL PATHOLOGIC CHANGES:  PRIOR BIOPSY SITE CAVITY/ CHANGES. *** PATHOLOGIC STAGE: pT3(m) N0(i+)(sn), (AJCC 7th Edition) *** D. SOFT TISSUE, NEW INFERIOR MARGIN, EXCISION:  FIBROADIPOSE CONNECTIVE TISSUE AND SCATTERED ATROPHIC BREAST PARENCHYMA; NEGATIVE FOR MALIGNANCY. Comments: Macroscopically, two masses were noted within the outer upper and outer mid regions, separated by approximately 1.5 cm. However, sampling of the. intervening tissue confirms the presence of invasive lobular carcinoma. The masses have a similar histologic appearance of invasive lobular carcinoma, grade 2. Therefore, the upper outer/mid tumors are best classified as a single mass and staged as pT3. A smaller separate tumor. is noted within the inner upper quadrant. ) and ancillary studies are reviewed.. The prior core biopsy This case received prospective peer review. ** ** Report Electronically Signed Out CLINICAL DIAGNOSIS AND HISTORY:S ear-old female with left breast cancer. PRE-OPERATIVE DIAGNOSIS: Breast cancer.. POST-OPERATIVE DIAGNOSIS: None provided.. Continued on Next Page Page 2 FOR OFFILIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 3 ---
+rOX OFFICIAL USE CWLY - PERSOXAL DATA - PRIVACY ACT OP 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION: A: Received fresh, labelled with the patient's name and designated, "Sentinel Node #1" consists of 2.0 x 2.0~x 0.6 cm irregular portion of red-yellow soft tissue. Sectioning reveals a single 1.3  0.5 x 0.4 cm pink-tan lymph node. The lymph node is bisected and entirely submitted in 2 cassettes.. B: Received in formalin, labeled with the patient's name and designated, "Left Axillary Tissue" consists of two irregular shaped fragments of yellow lobular adipose tissue measuring 2.3 and 1.3 cm in greatest dimension. Sectioning reveals six possible lymph nodes measuring up to 0.2 cm in greatest dimension each. The specimen is entirely submitted in three cassettes as follows: Bl- five possible lymph nodes; B2- one possible lymph node, bisected; B3- remaining adipose tissue. C: Receiv... fresh, labelled with the patient's name and de. .ated, "Left Mastectomy (Long-Lateral; Short-Superior)" consists of s0 gram mastectomy specimen oriented with a short stitch superior and ..ng st-. lateral. The specimen measures 25.0 cm medial to iateral; 21.0 cm r  to inferior; and 4.0 cm anterior to posterior. The light!. ed superficial skin ellipse measures 24.0 x 14.2 cm and J cm centrally located, everted nipple. No discharge is The deep margin is inked black. Serial sections reveal a 4.0 x 4. x 3.0 cr poorly defined mass in the mid-outer breast (mass #1). On sectsen'n?. t cut surface is firm, pink-white and shows a 0.3 cm bloc spsy cavity. The mass comes to within 0.5 cm of the deep ser/outer quadrant and lower/outer quadrant fibrous tissue mass is markedly dense and nodular. Located in the Juau.'ant, adjacent to the superior-medial portion of mass #1, is a sec.. fairly well defined mass measuring 0.9 x 0.8 x 0.5 cm. This mass is lcsated 2.0 cm from the deep margin. The second mass is located approximately 1.5 cm from the first mass. The remainder of the specimen is. composed of lobulated, yellow-tan adipose tissue admixed with a moderate amount of otherwise unremarkable fibrous tissue. Located along the lateral edge of the specimen (at the junction of the deep and superficial margins) there is a single 0.4 cm ill-defined induration. This lateral margin is inked blue. No lymph nodes are identified. Representative sections are submitted as follows: C1- skin; c2- upper/outer quadrant mass; C3- upper/outer quadrant deep margin (to c2); C4- outer mid (OM) mass with cavity and deep margin; C5- deep margin, OM; C6- outer mid mass; c7-c9- additional outer mid mass; c1o-cii- induration along margin; C12- upper/inner quadrant; c13- lower/inner quadrant; C14-lower/outer quadrant; c15-upper/outer quadrant; C16- nipple; C17- sections of firm areas between first and second mass.. Matched sections of c1,c2,C4,C6-c9 and c12-c15 are submitted in Ocr and Page 3 Continued on Next Page. FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 4 ---
+FOR OFYICIAL USE OWLY - PERSOMAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Specimen #: Patient: GROSS DESCRIPTION (continued) : Paraffin per cBcp protocol. Received in formalin, labeled with the patient's name. D: d designated, "New Inferior Margin" consists of an unoriented. cm. fragment of yellow lobular adipose tissue measuring 14.0 x 6.5 x 3.0 The specimen is inked.  Serial~ sectioning reveals a yellow lobular cut surface with no well defined lesions or nodules grossly identified and scattered areas of dense fibrous tissue. Representative sections are submitted in seguential order in six cassettes representing various fibrous areas. Time in formalin: >80 hours. Page 4 End of Report FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
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diff --git a/output/text/dd7b442e-166a-40a7-a428-2268a28e761e.txt b/output/text/dd7b442e-166a-40a7-a428-2268a28e761e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ab9099c7e210e94711f8435df25ae3b761a39fdc
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+
+--- Page 1 ---
+UUID: B7BF98C5-9222-43BC-A08D-5A3546B627050 TCGA-J7-A8I2-01A-PR Redacted Clinical Case Report (For Collection of Cancerous Tissue) 1cD-c 3 Carenra,psuisay renak ceQl 8z60/3 Informed Consent. y J/ze/13 I personally informed this patient that a specimen(s) would be collected to be used for research. purposes. I reviewed the RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator Signature bate Clinical Information GENERAL INFORMATION Date of Birth (mm/dd/yyyy) Height  Marital Status Race Temperature  Single  Married VIETNANESE Gender Weight  Divorced  Widow  Blood Pressure Heart Rate Male  Female HISTORY OF PRESENT ILLNESS Symptoms: Heyrct'en Clinical Findings: Performance Scale (Karnofsky Score):.  100 Asymptomatic  80-90 Symptomatic but Fully Ambulatory 760-70 Symptomatic, in bed less than 50% of day  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden  20-30 Bed Ridden CURRENT MEDICATIONS Drug Dose  Route Frequency Date (mm/dd/yyy) To / To 1 / To 1 1 To 1 To 1
+
+--- Page 2 ---
+PAST MEDICAL HISTORY Diagnosis/Disease/Disorder/Injury Diagnosis Date Treatment Status OB/GYN HISTORY  Menopausal Status Date of First Menses # of Pregnancies  Pre-menopausal  Peri-Menopausa! Date of Last Menses # of Live Births  Post-menopausal Birth Control:  Condom.   Oral Contraceptive   Iud  Hormone Replacement  Other: Therapy: SOCIAL HISTORY Occupation: Environmental Hazards: Smoking History Current Status TYPE  Packs/day Duration When Quit  yes ANO (yrs) (y Alcohol Consumption. Current Status TYPE Drinks/day Duration When Quit qyES nO DAantlday (yrs) (yr) Drug Use Current Status TYPE Frequency Duration When Quit  yes 9NO (yrs) (yr) FAMILY MEDICAL HISTORY Relative  Diagnosis Age of Diagnosis LAB DATA Test Result Date Test Result Date HIV EPNegative  Positive: CEA  Negative  Positive: Hep B  Negative  Positive: CA 15-3  Negative  Positive: Hep C Negative  Positive: CA 19-9  Negative  Positive: AFP  Negative  Positive: PSA  Negative  Positive: Other: Other:  Negative  Positive: Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+DIAGNOSTIC STUDIES Study  Results Date Ultrasound X-Ray CT  A tmh Way Endoscopy MRI Biopsy CLINICAL DIAGNOSIS Preoperative Clinical Diagnosis KrereusCossess) Location of Suspected Involved Lymph Nodes Location of Suspected Distant Metastasis Clinical Staging Date of Diagnosis TA NOMO Stage: T Treatment Information. SURGICAL TREATMENT Procedure Date of Procedured Lekectr oy? the ll -iccce) Primary Tumor Organ Detailed Location Size L rel neye 3x/f x f cm Extension of Tumor Lymph Nodes Description Location of Lymph Nodes.. # of Lymph Nodes  Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Organ Detailed Location  Size Surgical Staging NAmO Stage:  NEOADJUVENT THERAPY (Chemo, Radiation, Immuno, Hormonal, or Molecular) Drug/Treatment Dose Route Frequency Date (mm/dd/yyyy) To To To 1 / To 1 To 1 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by: -- Date: . Time: Preserved by: - Date. Time... SPECIMEN TYPE (# of samples provided) Frozen Paraffin Block  Blood/Serum/Plasma Slide Diseased Normal Diseased Normal Diseased Normal Diseased  Normal 2 2 2 Time to LN2 Time to Formalin Time to LN2 nin min min PATHOLOGICAL DESCRIPTION Primary Tumor Organ  Size Extension of Tumor Distance to NAT cillnee Tal mscee 5 xAx Acm cm Lymph Nodes Location # Examined # Metastasized Distant Metastasis Organ  Detailed Location Size Pathologica! Staging pT J N O M O Stage: T  Notes: 4
+
+--- Page 5 ---
+Consolidated Pathology Diagnosis Cell Distribution + Structaral Pattern Diffuse + Streaming Mosaic  Storform Necrosis Fibrosis Lymphoc tic Infitrationd X  Palisading Vascular Invasion Cstic Degeneration Clusterized Bleeding  Alveolar Formation X M xoid Change Indian File Seum ryous. +- Adenonatous Sarcomatous + Lymohomatous Squamoid Cell Glandutar celt Round Cell  Large Ce Spindie Cell Cell Stratification Fibroblast Small Cel Keratin Secretion Osteobiast  RS Ce/RS Like Desmosome Intract. Vacuole Lipoblast Inflan. Cell Peart Gland formation Myobiast  Plasma Cell Cellular Differentiation:d o Well  Moderate  Poor Nucleer At rpla: 0 1 II Aniso Nucleosis Hyperchromatism  Nuceolar Proninentd A Muitinucieated Glart Cell. Mitotic Activity F Nuciear Grade: D4 90 Final Pathology Repor!. Comments: Date Director, Research Pathology riter W:1/8/3 INTEGRATED REPORT OF FINDINGS BY COLLASORATORS AND GUALIFIED
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diff --git a/output/text/dd8717c1-1162-4164-b639-41a1b458e2b4.txt b/output/text/dd8717c1-1162-4164-b639-41a1b458e2b4.txt
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index 0000000000000000000000000000000000000000..255cd7238ea8ed7688e5128ca5ebec3d21b791f2
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+FINAL DIAGNOSIS: PARt 1: LEft AxIlLA, SEntinel nODe # 1, excision -- ONE LYMPH NODE (0/1), NEGATIVE FOR TUMOR. Part 2: breast, Left, total mastectomy - A. TWO SEPARATE FOCI OF INVASIVE DUCTAL CARCINOMA. B. LARGER INVASIVE DUCTAL CARCINOMA, 2:2 CM, nOT TINGHAm SCORE 6/9 (TUBULES 3, nUCLEAR GRADE 2, MITOSIS 1). LOCATED IN THE LOWER OUTER QUADRAnT AT THE 4 :00 O' CLOCK POSITION. c. ANGIOLYMPHATIC INVASION NOT SEEN (See comment). D.  PERINEURAL INVOLVEMENT PRESENT. E. TUMOR IS 0.3 CM FROM CLOSESTE POSTERIOR MARGIN. F. SMALLER INVASIVE DUCTAL CARCINOMA, 1.3 CM, NOTTINGHAM SCORE 7/9 (TUBULES 3, NUCLEAR GRADE 2, MItOSIS 1), LOCATeD 4.0 Cm AnTERiORLy. G. DUCTAL CARCINOMA IN SITU, SOLIDTYPE, NUCLEAR GRADE 2-3, REPRESENTING 10% OF TUMOR VOLUME. H. ANGIOLYMPHATIC INVASION NOT SEEN 1. ALL MARGINS ARE FREE OF TUMOR J. CHANGES CONSISTENT WITH BIOPSY SITE. K. SKIn AND NIPPLE, FREE OF TumOR. L. FIBROCYSTIC CHANGES WITH ATYPICAL DUCTAL EPITHELIAL HYPERPLASIA ASSOCIATED WITH MICROCALCIFICATIONS. CASE SYNOPSIS: 1CD-0-3 SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST Carcuom, vifi/fnsfny sluctl, N0r 85oof3 LATErALiTy: Left Si#:brsot,Nos C50.9 3/13fn h PROCEDURE: Simple mastectomy LOcATION: Lower outer quadrant SIZE OF TUMOR: Maximum dimension invasive component: 2.2 cm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: Yes TUmOR AGGREGATE SiZE: Sum of the sizes of multiple invasive tumors: 3.5 cm TUMOR TYPE (invasive component): Ductal adenocarcinoma, NOS NOTTINGHAM SCORE: Nuclear grade: 2 Tubule formation: 3 Mitotic activity score: 1 UUID: 06905BD3-4D17-4625-8631-46CA81D18478 Total Nottingham score: 6 TCGA-BH-A0AY-01A-PR Nottingham grade (1, 2, 3): 2 Redacted ANGIOLYMPHATiC INVASION: No DERMAL LYMPHATIC INVASION: No CALCIFICATION: Yes, benign zones Tumor type, in situ: Solid DCIS admixed with invasive carcinoma Percent of tumor occupied by in situ component: 10 %. SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No Distance of invasive tumor to closest margin: 0.3 mm. SURG MARGINS INVOLVED BY IN SITU COMPONENT: rAuci S UiSEASE Of NIPpLE:  No LyMPH NODES POSITIVE: No Lymph nODeS EXAMInED: 0 METHOD(S) OF LYMPH NODE EXAMINATION: 1 SENTINEL NODE METASTASIS: H/E stain ONLY KERATIN POSITIVE CELLS ARE PRESENT: No METASTASES TO iPSILATERAL INTERNAL MAMMARY LYMPH NODE (IF APPLICABLE): No SKIN INVOLVED (ULCERATION):  No NON-NEOPLASTIC BREAST TISSUE: ADH, FCD No t Stage, pathologic: N Stage, patholOgiC: pT2 m Stage, PAthOlOgIC: pN0 ESTROGEN RECEPTORS: pMX PROGESTERONE RECEPTORS: positive HER2/NEU: positive zero or 1+ UPAA 13/n
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diff --git a/output/text/dd941df7-4402-4ac9-8d2f-0b793c8600e8.txt b/output/text/dd941df7-4402-4ac9-8d2f-0b793c8600e8.txt
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+Pathology Report DIAGNOSIS (A) LEFT KIDNEY AND ADRENAL GLAND: RENAL CELL CARCINOMA, CHROMOPHOBE TYPE, FUHRMAN NUCLEAR GRADE 3 (10.5 CM). TUMOR CONFINED TO THE KIDNEY.(SEE COMMENT) Ureteral, vascular and soft tissue margins of resection free ot tumor. One perinephric lymph node, no tumor present.. Adrenal gland, no tumor present. (B) RETROPERITONEAL LYMPH NODES: Ten lymph nodes, no tumor present. COMMENT Although the tumor is in close proximity to the renal sinus, multiple sections failed to demonstrate invasion into the renal sinus adipose tissue. Tumor is present within vascular/lymphatic spaces in the sinus GROSS DESCRIPTION (A) LEFT KIDNEY AND ADRENAL GLAND - A Ieft kidney with surrounding perinephric fat (21.0 x 12.5 x 10.5 cm, overall), and adrenal gland (7.5 x 1.5 x 0.3 cm). The kidney (21.0 x 12.3 x 9.0 cm) contains a variegated tan-red well-circumscribed mass (10.5 x 12.3 x 9.0 cm), that replaces about 90% of renal parenchyma, pushes into the perinephric fat and into the pelvis and has possible extensive involvement of the renal sinus. The remainder of the renal parenchyma appears unremarkable with a well defined cortico-medullary junction. The renal vein, artery and ureter margins appear unremarkable. Cut section of the adrenal gland reveals unremarkable adrenal parenchyma. One lymph node (0.8 x 0.6 x 0.5 cm) is. identified in the perinephric fat. INK CODE: Black - perinephric fat margin. SECTION CODE: A1, renal artery, vein and ureter margin, en face; A2-A4, tumor to perinephric fat margin (closest to tumor); A5, one. bisected lymph node; A6-A8, tumor to renal pelvis; A9-A14, representative sections of tumor (A12 contains section with probable tumor in parenchymal vessel; A15, A16, tumor to normal kidney. parenchyma; A17, uninvolved renal parenchyma; A18, adrenal gland; A19-A21, additional sections from tumor adjacent to renal sinus. (B) RETROPERITONEAL LYMPH NODES - A fragment of soft tissue measuring 8.0 x 2.0 x 0.4 cm. Multiple lymph nodes ranging from 0.6 x 0.4 x 0.4 cm to 2.2 x 0.8 x 0.6 cm identified. SECTION CODE: B1, three lymph nodes; B2, two lymph nodes; B3, one lymph node (1.8 cm), bisected; B4, one lymph node, sectioned; B5, one lymph node, bisected; B6, one lymph node (2.2 cm), bisected; B7, one Iymph node. CLINICAL HISTORY Left renal mass, retroperitoneal mass. SNOMED CODES
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diff --git a/output/text/dd9458fa-a40f-455e-901b-c6744ee4611d.txt b/output/text/dd9458fa-a40f-455e-901b-c6744ee4611d.txt
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index 0000000000000000000000000000000000000000..ac1f00a8cfad4d35249d0c2968b14c2463779e0e
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+UUID:7C921918-BBC3-490D-9D7C-3D250564D395 Redacted Department of Pathology TCGA-P4-A5EB-01A-PR Tissue Source Site (Tss) #: Patient ID: Patholgy Accession No: Normal Sample ID: Pathology Report DIAGNOSIS (A) RIGHT KIDNEY: RENAL CELL CARCINOMA (5 CM IN GREATEST DIMENSION), PAPILLARY TYPE 2, FUHRMAN NUCLEAR GRADE 3, CONFINED TO THE KIDNEY. Simple renal cyst (3.0 cm) in the upper pole. Cystic calyceal dilation in the mid portion of kidney. Margins of resection (ureter, renal artery and renal vein), negative for carcinoma.. GROSS DESCRIPTION (A) RIGHT KiDNEY - A radical nephrectomy specimen 18.0 x 13.0 x 11.0 cm including the right kidney (13.0 x 7.0 x 4.2 cm). A segment of renal artery, renal vein and ureter (12.5 cm in length x 0.7 average diameter).. There is a 5.0 x 4.2 x 4.0 cm well circumscribed tumor mass in the lower pole of kidney. The tumor is tan-white with foca! areas of hemorrhage and tan-yellow discoloration. Two cysts are present, one in the mid kidney (3.8 x 3.0 x 3.0 cm) with rough lining, the other in the upper pole (3.0 x 2.5 x 2.5 cm) with smooth lining.. The solid tumor does not invade into the perinephric adipose tissue, renal sinus, or the renal vein. The tumor does not extend into Gerota's fascia. The uninvolved renal parenchyma is grossly unremarkable.. SECTiON CODE: A1, margins (ureter, renal vein and artery); A2-A7, tumor and adjacent renal parenchyma; A8, A9, mid pole cyst; A10, A11, superior pole cyst and normal; A12, uninvolved renal parenchyma.. CLINICAL HISTORY None given.  SNOMED CODES T-71000, M-Y7343 "Some tests reported here may have been developed and performance characteristics determined by These tests have not been specifically cleared or approved by the U.s. Food and Drug Administration." --END OF REPORT- z4D o-3 Cb4.9 Site! 1/31
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diff --git a/output/text/dda57e74-0eed-4b79-afb6-02204d452560.txt b/output/text/dda57e74-0eed-4b79-afb6-02204d452560.txt
new file mode 100644
index 0000000000000000000000000000000000000000..864d073f9f9098788bb701e4720e45b3bf8c7d22
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+ UUID:20F84480-449D-45CD-AEDC-509BE72C6B846 PATIeNT HISTORY:  TCGA-BT-A20N-01A-PR Redacted The patient is a -year-old male with carcinoma of the blaoder. PRE-OP DIAGNOSIS: Bladder CA. POST-OP DIAGNOSIS: Same. PROCEDURE:. Radical cystoprostatectomy. FINAL DIAGNOSIS: Part 1: Lymph nOdeS, Right PelVIC, ExcisiOn -- NO eviDence OF CarcinomA in Three (0/3) Lymph nODes ExAmineD. Part 2: Lymph nodes, Left pelvic, excision  /cs-0-3 nO evidence Of carcinomA in four (0/4) Lymph nODes ExamIneD. Part 3. Left ureter, Biopsy--- BenIgn UreTeral. Tissue. Site: b1andw, trigone Cl7.0 ' part 4. right ureter, siopsy---  Senign ureteral tissue. 4/7/u h Part 5: BLADoer, Distal UreTers, ProstAtE, BILAteral SeminaL Vesicles And BILAteral VASA DEFERENTIA, RADICAL CYSTOPROSTATECTONY- BLADDER: A. invAsive urotheLiAl (transTiOnAl CeLl) CArCinoma (8.5 Cm), High GraDe (WHonsUp, GRADe 3 Of 4 (ASH)--- B. THE CARCInOMA InVADes THE DEEP DETRUSOR mUSCLE AND FOCALLy eEXTeNDs InTO PERIVeSiCULAR ADIPOSE TISSUE (SUDE SN). C. ALL SURgICAL MArGINS ARE FREE OF TUMOR (Ses parts 3, 4 and 8). D. FOCAL PERINEURAL INVASION IS IOENTIFIED. E. nO defiNTive Evidence Of AnGIolymphATIC invAsiON Is IDenTifieD. TNm PathOLOGIC STAging = T3a N0 mX. PROSTATE-- A microscopic focus Of invasive moderateLy DifferentateD ADenocarcinomA, GleAsOn SCore 3 + 3 -6 (SLIDE 58). B. Tumor involves the LeFt LoSe and hAs A greatest nodulAr Diameter Of 0.3 Cm.e c. The tumor involyes Les8 than 3% of the total prostate volume Examned.e The tumor is organ confined and shows no eyidence of extracapsular extension.e D. E. BiLateRal seminal VEsicles are Free Or carcinonAe F. All examined surgical resection margins are free of tumor. G.  POCAL HigH GRADE PROSTATIc InTRAEPITHELiAL NEOPLASiA IS IDENTIFIED. H. Tnm PAThOLOgIC STAge - pT1a N0 mx. Part S: Lymph nodes, LEft ILjac, Excision - NO evidence Of carcinomA in TwO (0/2) Lymph nODes Examined. Part 7: Lymph nodes, Right Iliac, exciston -- NO EviDenCe OF carcinomA in Two (0/2) Lymph nooE8 examineD. Part 8: Urethral Resection margin, Biopsy. NO EVIDENCE OF CARCINOMA IDENTIFIED.  SYNOPUIC : PRIMARY yRINARY BLADDER/URETHRA TUMORSS A. Location of primary tumor:  1. Dome. 4. Right wall 7. Ureter 2. Anterlor wall 10. No residual tunor 5. Left wall 8. Urettra 3. Posterior wall 6. Trigone Procedure: 3 9. Mutticentric B. 1. Partial cystectomy 3. Cystoprostatectomy 2. Total cystectomy 4. Other C. Size (if multicantric, maximum dimension of the most deply invasive or largest tumor): 8.5 cm D. Non-Invasive neoplastic lesiona: '7#?# 1. Papilloma 4. Flat CIS 2. Inverted papidome 3. Papillary TCCa 5. Other E Invssive neoplaale: 1 1. Urothellal (Transitional cell) carcinome 6.Mixed urothelisl carclnome 2. Squsmous carcinoma 7. Lymphomaleukemia 3. Adanocarcinoma 8. Sarcom 4.1 Sarcomatold carcinoma 5. Smal cel/neuroendocrine carcinoms 8. Metastasis/direct extension from a contiguous primary 10. Other Grade: 3(Ash for TCCa grados 1-4)/ # (WHO for TCCa grades 1-3)/HG (WHO / ISUP (LMP. LG, HG) F G Non-neoplastic and other conditions: #7?#7. 1. Von Brunn's nests, cystitis cystica/glandularis, Intestinal metaplasia Nephrogenic metaplasia/ adenoma : Granulomatous cystitis 4. Interstitial cystitis 5. Innlammatory pseudotumors 6. Carbuncie 7. Malakoplaxia a. Other Margine ot resection: 2 1. Positive Angiotymphatic invasion: 2 Negative 1. Yes Perinsural invasion: 2 ? Mitotic activity:  per 10 high power fields 1. Yes K. 2. No L Flat dysplasia in background: 2 Number of positive iymph nodes: 1. Yes M. 2. No Crkeria. N. Totai number of tymph nodes examined: 11 Diagnors Discrcnancy O Extracapsular spread of lymph node metastases: 2 1. Yes HIrAA Discrepat.cy P Prostate/seminal vesicles (f cystoprostatectomy) P1. invoived by biadder neoplasm: 1 Dual/Syn hrunous Pri P2. Concurrent primary invasive prostatic neoplasm: 1 1. Yes 1. Yes WALIFI P3. High grade PiN: 1 Q. TNM stage:T 39 1. Yes N# M# 2. No
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+page 1 / 1 Department of Cancer Pathology copy No. Date: Examination: Histopathological examination Internal invoice No. Value of diagnostic procedure. Examination No.: Patient: XXX PESEL: XXX Age: Gender: F Material: 1. Multiple organ resection -- left breast,with axillary tissues jcs-0-3 Unit in charge: Carcin ome, mfiAtna#irg ductl suL mucinow Physician in charge:. 8503/3 Material collected on: Material received on: Sit: buaat, Nos c50.9 Expected time of examination: up to 8 working days 414 Clinical diagnosis: Cancer of the breast.. Examination performed on:. Macroscopic description: Left breast'sized 22.4 x 14.2 x 5.3 cm removed along with axillary tissues sized 8 x 9 x 3.5 cm and a 24.3 x 8.2 cm skin flap. Weight 860 g. Tumour sized 5 x 3.5 x 5.5 cm found on the boundary of outer quadrants, 2.4 cm from the upper boundary, 0.4 cm from the base and 1.6 cm from the skin. Microscopic description: Carcinoma ductale invasivum (partim mucinosum) - NHG2 (2+2+3/24 mitoses/10 HPF - visual area: 0.55mm). Carcinoma intraductale mamillae. Glandular tissue with lesions of the type mastopathia fibrosa. Invasive lesions 0.5 cm away from the base. AXILLARY LYMPH NODES: Metastases carcinomatosae in lymphonodis (No II/xLIII). Histopathological diagnosis:e Carcinoma invasivum partim mucinosum mammae sinistrae. Invasive ductal and partially mucinous carcinoma of the left breast.!. Metastases carcinomatosae in lymphonodis axillae (No II/xLli). Cancer metastases in axillary lymph nodes. (NHG2, pT3, pN1a). Compliance validated by: Examination performed on: Results of immunohistochemical examination: Estrogen receptors found in over 75% of neoplastic cell nuclei. Progesterone receptors found in 10-75% of neoplastic cell nuclei. HER2 protein stained with HercepTestTM by DAKO. Positive reaction in invasive carcinoma cells ( Score = 3+ ). Compliance validated by: CONTACT YOUR DOCTOR WITH THIS REPORT! UUID: EEA1260E-A667-4373-9DC5-96855E4ABF070 TCGA-D8-A1X3-01A-PR Redacted ase is (circe ISQUALIFIED
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diff --git a/output/text/dddd6a42-62b5-4960-b366-edb56efcbcc3.txt b/output/text/dddd6a42-62b5-4960-b366-edb56efcbcc3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..bae555c4e397e117812c3788caedaf4d40725e46
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+1cd-0-3 Carcinoma, mngiltrating duct, noS 8500|3 12|8/10 lw C50.9 S.re ct: bresst, Nos TSS: UUID:E4D1A7DC-62B1-44D8-A747-5A19842C6F69 TCGA-E2-A15H-01A-PR Redacted SPECIMENS: A. CLUSTER OF SENTINEL NODES RIGHT BREAST B. RIGHT BREAST MASS SPECIMEN(S): A. CLUSTER OF SENTINEL NODES RIGHT BREAST B. RIGHT BREAST MASS GROSS DESCRIPTION: A. CLUSTER OF SENTINEL NODES RIGHT BREAST Received fresh are four tan pink lymph nodes ranging from 0.7 x 0.6 x 0.3cm to 1.1 x 0.7 x 0.6cm. A touch prep is taken. Toto A1. B. RIGHT BREAST MASS Received fresh labeled with the patient's identification and "right breast mass" is a previously inked 23g, 7.5 x 5 x 2cm needle localized lumpectomy with radiograph. Ink code: anterior-yellow, posterior-black, superior-blue, inferior- orange, medial-green, lateral-red. Specimen is serially sectioned from superior to inferior into 7 slices revealing a 1.5 x 1.5 x 1cm tan white firm well circumscribed mass, 0.1cm from the closest posterior margin in slices 4-5. A portion of the specimen is submitted for tissue procurement. Representatively submitted: B1: superior margin slice 1 B2: slice 2 B3-B4: slice 3  B5-B6: slice 4 with mass in B6 B7-39: slice 5 with mass in B8 B10-B12: slice 6 B13-B15: inferior margin slice 7 DIAGNOSIS: A. LYMPH NODES, SENTINEL, RIGHT AXILLA, EXCISION: - MEATASTATIC CARCINOMA TO ONE OF FOUR LYMPH NODE (1/4), MEASURING 0.1-CM (MICROMETASTASES), WITH NO EXTRANODAL EXTENSION, SEE NOTE. B. BREAST, RIGHT, WIDE LOCAL EXCISION: - INVASIVE_DUCTAL CARCINOMA, SBR GRADE 2, MEASURING 1.1-CM - HIGH NUCLEAR GRADE, DUCTAL CARCINOMA IN SITU, SOLID AND CRIBRIFORM TYPES WITH CENTRAL NECROSIS AND MICROCALCIFICATIONS - INVASIVE TUMOR PRESENT AT ANTERIOR SURGICAL RESECTION MARGIN - DCIS PRESENT AT ANTERIOR AND MEDIAL, WITHIN 1 MM FROM POSTERIOR AND 2 MM FROM SUPERIOR MARGINS - LYMPHOVASCULAR INVASION PRESENT - BIOPSY SITE CHANGES WITH FIBROSIS - See synoptic repOrt. NOTE: A small cluster of tumor cells is identified in the touch preparation. Dr. concurs. SYNOPTIC REPORT - BREAST Specimen Type: Excision Needle Localization: Yes - For mass Laterality: Right Invasive Tumor. Present Multifocality: No WHO CLASSIFICATION  Invasive ductal.carcinoma, NOs 8500/3 Tumor size: 1.1cm Tumor Site: Not specified Margins:  Involved at anterior Extent:: focal Tubular Score: 2 Nuclear Grade: 3 Mitotic Score: 2 Modified Scarff Bloom Richardson Grade: 2
+
+--- Page 2 ---
+Necrosis: Absent Vascular/Lymphatic Invasion: Present Extent:  focal Lobular neoplasia: None Lymph nodes: Sentinel lymph node only. Lymph node status: Positive 1 / 4 Micrometastases: Yes DCIS present Margins involved by DCiS: anterior and medial DCIS Quantity: Estimate 10% DCIS Type: Solid Cribriform DCIS Location:Both associated and separate from invasive tumor masse Nuclear grade: High Necrosis: Present Location of CA++: DCIS ER/PR/HER2 Results ER: Positive PR: Positive HER2: Positive by FISH Performed on Case: OUTSIDE SLIDES  Pathological staging (pTN): pT 1c N 1a CLINICAL HISTORY: None provided. PRE-OPERATIVE DIAGNOSIS: Right breast mass. INTRAOPERATIVE CONSULTATION: TPA: Cluster of sentinel nodes right breast- Negative for carcinoma: Diagnosis called to Dr. at by Dr. B. GROss ExAMINATION: Right breast mass: 1.5cm tumor, <1mm from deep margin. Diagnosis called to Dr. at by Dr. ADDENDUM: ONCOTYPE DX BREAST CANCER ASSAY RESULTS: Recurrence Score: 44 CLINICAL EXPERIENCE: Patients with a recurrence score of: 44 in the clinical validation study had an average. rate of Distant Recurrence at 10 years of 30% ER Score: 8.9  Positive PR Score: 6.1 Positive Her2 Score: 12.1 Positive Interpretation: ER Negative < 6.5 Positive >= 6.5 PR Negative < 5.5 Positive >= 5.5 Her2 Negative <10.7 Positive >=11.5Equivocal = 10.7 - 11.4 See separate report for further information.. Test performed at: Gross Dictation: Microscopic/Diagnostic Dictation: Pathologist,. Final Review: Pathologist. Final: Pathologist, Addendum: Pathologist,  Addendum Final: Pathologist,.
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diff --git a/output/text/dde7178f-6bfc-4c0c-898c-cd2b053d3f6c.txt b/output/text/dde7178f-6bfc-4c0c-898c-cd2b053d3f6c.txt
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+TSS: Ics-0-3 Cainoma, mifiltnutng cluctel Nos 85~0sf SPECIMENS: 1nL Sin: brusst, uppwmnw A. NON-SENTINEL NODES RIGHT AXILLA Hes/1 gusdrint B. RIGHT BREAST Dc50.2 SPECIMEN(S):E CQcF 9ihv: bUsot n0s cs0.9 A. NON-SENTINEL NODES RIGHT AXILLA B. RIGHT BREAST INTRAOPERATIVE CONSULTATION DIAGNOSIS: TPA: Lymph nodes, right axillary non-sentinel, biopsy: Two lymph nodes positive for carcinoma on tough prep. By Dr. called to Dr. GROSS DESCRIPTION: A. NON-SENTINEL NODES RIGHT AXILLA Received fresh and labeled with the patient name designated "A -- non-sentinel nodes right axilla", are 2 portions of fibroadipose tissue demonstrating 2 presumptive palpable lymph nodes; one lymph node measures 3.5 x 1.2 x 0.8 cm, the second measures 2.0 x 1.2 x 0.7 cm. Both nodes are bisected. Touch prep performed. One lymph node is submitted in cassette A1 and the second is submitted in cassette A2. B. RIGHT BREAST Received fresh and labeled with the patient name designated *B -- right breast", is a resected mastectomy specimen weighing 1,383 grams and measuring 29.5 x 22.0 x 4.0 cm. The attached axillary tail measures 13.0 x 7.2 x 1.5 cm. A suture indicates the axillary region. The posterior margin is inked black. The white-beige ellipse of overlying skin measures 21.8 x 11.0. The light beige areola measures 3.5 cm in diameter. The inverted nipple measures 1.0 cm in diameter. The surface of the skin is dense and wrinkled. The specimen is serially sectioned from medial to lateral. Cut section shows two firm beige distinct lesions; the larger lesion is located in the lower inner quadrant in the subareolar region and measures 3.6 x 2.2 x 1.5 cm located 4.4 cm from the smaller lesion. The smaller lesion is firm present in the upper inner quadrant measuring 1.0 x 0.9 x 0.8 cm. The larger lesion is 5.1 cm from the deep margin. The smaller lesion approaches the deep margin at a distance of 2.0 cm. The remainder of the specimen shows dark yellow lobulated adipose tissue. Many firm lymph nodes are demonstrated in the axillary tail ranging in size from 0.5 x 0.5 x 0.4 cm up to 2.5 x 2.0 x 1.0 cm. A portion of the specimen is submitted for tissue procurement. Representative sections are submitted as follows: B1-B2: The smaller lesion submitted entirely with overlying deep margin. B3-B9: Sections from the larger lesion B10: Margin overlying the larger lesion B11-B13: Sections of nipple B14: Section of skin adjacent to nipple B15: Additional section of skin B16-B17: Representative sections upper outer quadrant B18-B19: Representative sections lower outer quadrant B20: Additional section upper inner quadrant B21-B22: One bisected lymph node B23: One-half of one bisected lymph node B24: One bisected lymph node B25: Three possible lymph nodes B26: Three possible lymph nodes UUID:42E3E8C1-D18A-4457-B2F0-FE49F4C027D7 Redacted B27: Four possible lymph nodes TCGA-E2-A1LE-01A-PR 1111 B28: Four possible lymph nodes B29: Four possible lymph nodes B30: One lymph node B31: One lymph node  B32: One lymph node DIAGNOSIS: A. LYMPH NODE, NON-SENTINEL, RIGHT AXILLA, BIOPSY: - METASTATIC CARCINOMA TO TWO OF TWO LYMPH NODES (2/2), MEASURING 2-CM, WITH EXTRANODAL EXTENSION.
+
+--- Page 2 ---
+TSS: B. BREAST, RIGHT, MASTECTOMY AND AXILLARY NODE DISSECTION: - MULTIFOCAL, INVASIVE, DUCTAL CARCINOMA, SBR GRADE 3, LARGEST MEASURING 3.6-CM, PRESENT IN THE LOWER INNER AND UPPER INNER QUADRANTS AND INVOLVES NIPPLE AND ADJACENT SKIN - SURGICAL RESECTION MARGINS NEGATIVE FOR TUMOR - EXTENSIVE LYMPHOVASCULAR INVASION IDENTIFIED - METASTATIC CARCINOMA TO TWENTY FIVE OF TWENTY SIX LYMPH NODES (25/26), LARGEST MEASURING 2.1-CM, WITH EXTENSIVE EXTRANODAL EXTENSION - SEE SYNOPTIC REPORT AND SEE NOTE. NOTE: Breast biomarkers have been ordered and addendum report to follow. SYNOPTIC REPORT - BREAST Specimen Type: Mastectomy Needle Localization: No Laterality:  Right Invasive Tumor: Present Multifocality: Yes Tumor size:- 3.6cm Tumor Site: Upper inner quadrant Lower inner quadrant and nipple and adjacent skin Margins: Negative Tubular Score: 3 Nuclear Grade: 3 Mitotic Score: 3 Modified Scarff Bloom Richardson Grade: 3 Necrosis: Absent Vascular/Lymphatic Invasion: Present Extent: extensive Lobular neoplasia: None Lymph nodes: Axillary dissection Lymph node status: Positive 27 / 28 Extranodal extension DCIS not present ER/PR/HER2 Results ER: Pending PR: Pending HER2: Pending Pathological staging (pTN):  pT 2 N 3a CLINICAL HISTORY: A  -year-old Caucasian female post menopausal abnormal mammogram. Biopsy showed an adenocarcinoma, ER/PR-, Her2+, 2 masses at right breast seen. One at 12 o'clock position subareolar, 2nd mass at 1 o'clock posterior to 1st mass (3.0 cm). PRE-OPERATIVE DIAGNOSIS: Infiltrating adenocarcinoma ADDENDUM: SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimen:  Surgical Excision Block Number: B4 ER: Negative Allred Score: 0 = Proportion Score 0 + Intensity Score 0 PR: Negative Allred Score:  0 = Proportion Score 0 + Intensity Score 0
+
+--- Page 3 ---
+TsS: COMMENT: The Alred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring. range from 0 to 8.. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2. METHODOLOGY:  Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Immunohistochemistry was performed using the mouse anti-human ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) provided by following the manufacturer s instructions. This assay was not modified. Interpretation of the ER/PR immunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal review of staining performance. SYNOPTIC REPORT - BREAST HER-2 RESULTS Specimen: Surgical Excision Block Number: B4 Interpretation: POSITIVE Intensity: 3+ % Tumor Staining: 90% Fish Ordered: No METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Her2 analysis was performed using the FDA approved HercepTest (TM) test kit using rabbit anti-human HER2. This assay was not modified. External kit-slides provided by tne manufacturer (cell lines with high, low and negative HER2 protein expression) and in- house known HER2 amplified control tissue were evaluated along with the test tissue. Adequate, well preserved, clear-cut invasive carcinoma was identified for HER2 evaluation. Interpretation of the HER2 immunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal review of staining performance. This assay has been validated according to the 2007 joint recommendations and guidelines from ASCO and CAP and from the NCCN HER2 testing in Breast Cancer Task Force. Pathology Department takes full responsibility for this test's performance. Gross Dictation: Pathologist, Microscopic/Diagnostic Dictation: Patholoaist. Final Review: Patholoaist. Final: Pathologist,. Addendum: Pathologist, Addendum Final: Pathologis'
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diff --git a/output/text/de057976-c334-4712-ab68-7953ca47a2a1.txt b/output/text/de057976-c334-4712-ab68-7953ca47a2a1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c13bf588fd9f953d6467d5bd3f41faaf7c3e817d
--- /dev/null
+++ b/output/text/de057976-c334-4712-ab68-7953ca47a2a1.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+This is an unequivocal finding in the sense of an adenocarcinoma of the colon with extensive necrosis and poor differentiation (thus corresponding to G3) with penetration of all parietal layers and vascular infiltration (thus corresponding to pT3, L1, V1) with free resection margins in the mucosal region with a regular mucosa, submucosa and muscularis and free resection margins in the mesenchymal region and three lymph node metastases (corresponding to pN1).. In addition, there were diverticular formations.. Tumor classification: ICDO-DA-M G 3 pT3 L1, V1 pN1 (3 of 13 1ymph nodes)
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diff --git a/output/text/de18cee6-26f7-44f8-91e9-965e729455a0.txt b/output/text/de18cee6-26f7-44f8-91e9-965e729455a0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..956d1a552ef767a1bc4e780ed3cf18338642ddf3
--- /dev/null
+++ b/output/text/de18cee6-26f7-44f8-91e9-965e729455a0.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+/CA-0-3 UUID: 2BE28F5D-2DBB-476F-9AFF-6B2103ECF0CE Redacted Carcinomo, nifi/tsut7iq ductard lobules 8570f3 Sih: brsot, nxs c50.9 bw 913fu SPECIMEN A. Right axillary sentinel lymph node B. Left axillary sentinel lymph node C. Right breast biopsy - stitch is long anterior, short superior D. Left breast biopsy - long stitch anterior, short stitch superior E.  Superior margin - long stich anterior, short stitch superior CLINICAL NOTES CLINICAL HISTORY: -year-old white female with lobular carcinoma. prE-op Diagnosis:  Left breast cancer. POsT-oP DIAgNOsIs: Left breast cancer. FROZEN SECTION DIAGNOSIS AFS1-AFS3: Right axillary sentinel node. -No metastasis identified in 4 nodes. ( 0/4) BFsl, BFs2: Left axillary sentinel lymph node, excision. -No metastasis identified in 1 node. (0/1) GROSS DESCRIPTION A. Container A is labeled with the patient's name, medical record number and "right axillary sentinel lymph node". The specimen container holds a single piece of fibrofatty tissue. When dissected, there are four separate lymph nodes. The largest measures 1.8 x 1.5 x 1 cm. The remainder three smaller lymph nodes average 0.3 cm. AS-AFsl, AFs2 - One lymph node bisected; AFs3 - three remaining nodes.. B. Container B is labeled "left axillary sentinel lymph node". The specimen container holds a single rubbery tan lymph node, measuring 1.5 x 1 x 1 cm. AS-Block BFs-l, BFs-2 Bisected. C. Container c is labeled with the patient's name, medical GROSS DESCRIPTION record number and "right breast". The specimen container holds a single piece of fatty tissue, oriented by two sutures and posterior and 3 cm. from superior to inferior. The specimen margins are inked as follows: Blue-anterior, black-posterior, red- superior, green-inferior, yellow-medial, orange-lateral. The specimen is serially sectioned. On cut section, there is a firm tan mass,
+
+--- Page 2 ---
+measuring 2.1 x 1.8 x 1.5 cm., located approximately 3 mm. from the inferior margin of resection. Ascl-cl5.. D. Received fresh labeled "left breast biopsy" is a 4.5 cm (anterior to posterior) x 4.3 cm (medial to lateral) x 2.1 cm (superior to inferior) diffusely cauterized soft, lobulated, tan-gold-white portion of fibroadipose tissue with two sutures, as stated previously. The superior surface appears in keeping with the lining of a prior breast biopsy. The margins are inked as follows: Superior - blue, inferior - black, medial - green, and lateral Orange. The specimen is sectioned from anterior to posterior. Cut surfaces throughout the specimen consist predominantly of glistening lobulated golden yellow adipose tissue with a moderate amount of interspersed dense, focally nodular, tan-white fibrous tissue.  No definitive mass lesion is noted. The specimen is entirely submitted in a sequential manner from anterior to posterior in 9 blocks, as labeled. As-9. E. Received fresh labeled "superior margin" is a 2.5 cm. (anterior to posterior) x 1.8 cm (medial to lateral) x 1.7 cm (superior to inferior) soft, lobulated tan-gold-white portion of fibroadipose tissue with two sutures, as stated previously. The margins are inked as follows: Superior - blue, inferior - black, medial - green, and lateral - orange. The specimen is sectioned from anterior to posterior. The cut surfaces consist predominantly of glistening lobulated golden yellow adipose tissue with a moderate amount of interspersed tan-white fibrous tissue. No discrete mass lesion or abnormality is identified. The specimen is entirely GROSS DESCRIPTION submitted in a sequential manner from anterior to posterior in five blocks, as labeled. As-5.. BLock summARy: 1 - Perpendicular sections entire anterior margin cap, 2-4 - sequential sections, 5 - perpendicular sections entire posterior margin cap. MICROSCOPIC DESCRIPTION A. Sections of the right axillary sentinel lymph node demonstrate no evidence of metastasis in four lymph nodes. The lymph nodes in sections Asfl through AsF3 were examined by multi-level sectioning with H&E stain, as well as the.
+
+--- Page 3 ---
+immunohistochemistry for pankeratin. B. The left axillary sentinel lymph node demonstrates no. evidence of metastatic disease in one lymph node. Sections BFsl and BFs2 are examined by multi-level sectioning with H&E staining as well as the immunohistochemistry for pankeratin.. C. The following template applies to the right breast biopsy: Invasive Carcinoma: Present Histologic type: Mixed infiltrating lobular and grade I ductal carcinoma Histologic grade: Overall grade: 1 Architectural score: 3 Nuclear score: 1 Mitotic score: 1 Greatest dimension (pT): 2.3 cm (pT2) Specimen margins: Extremely close. invasive carcinoma is 0.9 mm from the lateral margin (orange ink block c12). MICROSCOPIC DESCRIPTION Vessel invasion:. Not identified. Calcification: Present. Ductal carcinoma in situ: Present. Histologic pattern: Solid. Nuclear grade: 2. Central necrosis: Not identified. % Dcis of total tumor (if mixed): Less than 5%.. Extensive intraductal component (present/absent): Absent. Specimen margins: Negative. Calcification: Present. Description of non-tumorous breast: Extensive proliferative changes. Comments: None. Prognostic markers: Previously reported. D. The following template applies to the left breast. biopsy. Invasive Carcinoma: Not identified. Ductal carcinoma in situ: Present. Histologic pattern: Cribriform. Nuclear grade: 2. Central necrosis: Not identified.
+
+--- Page 4 ---
+Tumor size (if pure in situ): Less than 2 mm. Specimen margins: Negative, nearest greater than 2 mm.. Calcification: Not identified. Description of non-tumorous breast: Extensive proliferative fibrocystic changes and extensive lobular carcinoma in situ.. Comments: E-cadherin stain was performed and demonstrates lack of MICROSCOPIC DESCRIPTION membranous staining within foci of lobular carcinoma in situ in blocks D5 and D7. E. The following template applies to the superior margin. of the left breast.. Invasive Carcinoma: Present. Histologic type:  Mixed grade 1 ductal and invasive lobular carcinoma. Histologic grade: Overall grade: 1. Architectural score: 3. Nuclear score: 1. Mitotic score: 1. Greatest dimension (pT): 1.2 cm (pTl). Specimen margins: Positive, invasive carcinoma extends to the green and black ink representing medial and inferior margins. Vessel invasion: Not identified. Calcification: Present. Ductal carcinoma in situ: Not identified. Comments: Immunohistochemical stain for pankeratin was utilized on two blocks to highlight the extent of tumor and the relationship to the margins.. Prognostic markers: Previously performed. 14x2, 15x3, 4x5, 20X9 DIAGNOSIS A. Right axillary sentinel lymph nodes, resection:. No evidence of metastasis to four lymph nodes (0/4).. B. Left axillary sentinel lymph node, resection: SURGICAL PATHOLOGY REPORT
+
+--- Page 5 ---
+DIAGNOSIS No evidence of metastasis to one lymph node (0/l).. C. Right breast, excisional biopsy: Infiltrating ductal carcinoma, mixed grade 1 ductal and lobular carcinoma, 2.3 cm in greatest dimensions.. Invasive carcinoma 0.9 mm from the lateral margin.. Ductal carcinoma in situ, solid and cribriform in subtype, nuclear grade 2, surgical margins negative. D. Left breast, excisional biopsy: Ductal carcinoma in situ, nuclear grade 2, cribriform and in solid subtype, less than 2 mm. In situ carcinoma 2 mm from the surgical margin. Proliferative fibrocystic changes and extensive lobular carcinoma in situ. E. Left breast, superior margin, excisional biopsy:. Infiltrating carcinoma, mixed grade 1 ductal and invasive lobular carcinoma, 1.2 cm. Invasive carcinoma extends to the medial and inferior margins of resection. M.D, (Electronic Signature)
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diff --git a/output/text/de1be4f3-c0f0-47fb-8272-d7d98aa52ae2.txt b/output/text/de1be4f3-c0f0-47fb-8272-d7d98aa52ae2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..abb1d419016b003a1b54dc2e147e46a6c2d03a1c
--- /dev/null
+++ b/output/text/de1be4f3-c0f0-47fb-8272-d7d98aa52ae2.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+Clinical Diagnosis & History: year old female with right breast cancer diagnosed on core biopsy. Specimens Submitted: 1: sp: Sentinel node #1, level 1, right axilla 2: sp: Sentinel node #2, level 1, right axilla (fs) 3: SP: Right breast mass Sp: Additional medial margin 5: SP: Superior lateral tissue, right breast. 6: SP: Level 1 and 2, right axillary contents with tags attached DIAGNOSIS: 1) SENTINEL NODE #1, LEVEL I, RIGHT AXILLA; EXCISION: UUID:15CAD156-1E40-4C83-B3ED-484964FE407F - METASTATIC CARCINOMA INVOLVING ONE LYMPH NODE (1/1). TCGA-AO-A0JE-01A-PR Redacted - NO EXTRANODAL BXTENSION IS IDENTIFIED. 2) SENTINEL NODE #2, LEVEL I, RIGHT AXILLA; EXCISION: - METASTATIC CARCINOMA INVOLVING ONE LYMPH NODE (1/1). - EXTRANODAL EXTENSION IS IDENTIFIED AND MEASURES O.5 CM. 3) BREAST, MASS. RIGHT; EXCISION: - INVASIVE DUCTAL CARCINOMA, NOS TYPE, HISTOLOGIC GRADE IHI/III (SLIGHT OR NO TUBULE FORMATION), NUCLEAR GRADE III/III (MARKED VARIATION IN SIZK AND SHAPB), MEASURING 2.5 CM IN LARGEST DIMENSION MICROSCOPICALLY. - DUCTAL CARCINOMA IN SITU (DCIS) IS ALSO IDENTIFIED, SOLID TYPE, WITH HIGH NUCLEAR GRADE AND SXTENSIVE NECROSIS. - LOBULAR INVOLVEMENT BY DCIS IS PRESENT. - THE DCIS CONSTITUTES <25% OF THE TOTAL TUMOR MASS, AND IS PRESENT ADMIXED WITH AND AWAY  FROM THE INVASIVE COMPONENT. - CALCIFICATIONS ARE PRESENT IN THE IN SITU, AND IN BENIGN BREAST PARENCHYMA. - NO VASCULAR INVASION IS NOTED. A MICROSCOPIC FOCUS OF INVASIVE CARCINOMA (<1 MM) IS PRESENT IN ONE OUT OF SIX SECTIONS OF THE ANTERIOR SHAVED MARGIN. - DCIS INVOLVES THE FOLLOWING SHAVED MARGINS: SUPERIOR (ONE OUT OF FOUR SLIDES).  INFERIOR (ONE OUT OF SIX SLIDES) AND POSTERIOR (TWO OUT OF FIVE ** Continued on next page ** 1cs~0-3 cerionn,nifiltratrmy duct,nos 85iv13 Sitr: hruot, Nos. 050.9 10j22fs
+
+--- Page 2 ---
+SLIDES) . Page 2 of 5 - THE NON-NEOPLASTIC BREAST TISSUE SHOWS BIOPSY SITE CHANGES, FIBROCYSTIC' CHANGES, AND USUAL DUCTAL HYPERPLASIA. - RECEPTOR STUDIES WERE PERFORMED ON PRIOR MATERIAL (CORE BIOPSY, 4) BREAST, RIGHT, ADDITIONAL MEDIAL MARGIN; EXCISION: BENIGN BREAST TISSUE WITH DUCTAL HYPERPLASIA WITHOUT ATYPIA. 5) BREAST, RIGHT, SUPEROLATERAL TISSUE; EXCISION: - FOCAL ATYPICAL DUCTAL HYPERPLASIA.S 6) LYMPH NODES, LEVELS I AND II, RIGHT AXILLARY CONTENTS; DISSECTION: - LEVEL I: BIGHT BENIGN LYMPH NODES (O/8). LEVEL II: SIX OF NINETEEN LYMPH NODES POSITIVE FOR METASTATIC CARCINOMA (6/19). -EXTRANODAL EXTENSION IS IDENTIFIED (2 MM). I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL). AND THAT I HAVE REVIEWED AND APPROVRD THIS REPORT. *** Report Blectronically Signed Out *** Gross Descrintian. 1) The specimen is received initially fresh for frozen section level 1, right axilla", and consists of a single lymph node measuring 1.8 x 1.2 x 0.6 cm. Cut section shows fleshy red-tan appearance. entirely submitted. Specimen is Summary of sections: U bisected lymph node 2.  The specimen is received fresh for frozen section consultation labeled, "Sentinel node number two, level 1, right axilla", and consists of a single lymph node measuring 1.2 x 0.7 x 0.4 cm.  The specimen is bisected and entirely frozen. A sample is submitted to Tps. Sumnary of sections: ** Continued on next page
+
+--- Page 3 ---
+FSC frozen section control. Page 3) The specimen is received fresh, labeled "Right breast mass". consists of a round piece of fibroadipose tissue measuring 11.5 x 10.0 x 4.0 It cm.  The specimen is oriented with short suture superior and long suture lateral.  The specimen is inked and the margins are entirely shaved. Sectioning of the central portion of the tissue reveals a firm stellate shaped gray-tan mass measuring 2.0 x 2.0 x 1.5 cm located at the lateral. aspect of the tissue. A portion of the tissue is submitted for tps. rest of the tumor is entirely submitted for histologic examination. The Representative section of the remaining tissue are also submitted. Summary of Sections:. S  superior margin inferior margin M medial margin lateral margin anterior margin P posterior margin tumor representative 4) The specimen is received fresh, labeled "Additional medial margin, stitch marks final margin breast". It consists of a fragment of fibroadipose tissue measuring 4.0 x 2.0 x 0.4 cm. The surface of the tissue. marked with stitch is inked black. The tisue is serially sectioned to 3 specimen is entirely submitted. The Summary of Sections: U - undesignated 5) The specimen is received fresh, labeled "Superior lateral tissue, right breast". It consists of a round piece of fibroadipose tissue measuring 3.0 x 2.0 x 0.5 cm.  The surface of the tissue marked with stitch is inked black and the tissue is serially sectioned to reveal a fibroadipose. cut surface with no gross pathologic abnormalities. entirely submitted.  The specimen is Summary of Sections: U - undesignatedd 6) The specimen is received fresh, labeled "Levels 1 and 2, right axillary contents, with tags attached". It consists of a fragment of adipose tissue measuring 7 x 4 x 3 cm with attached tags designating levels I and 2. Dissection of tissue reveals multiple lymph nodes ranging in size. from 0.2 x 0.2 x 0.1 cm to 1.2 x 1.0 x 0.5 cm.  All lymph nodes are entirely * Continued on next page **.
+
+--- Page 4 ---
+submitted LN1 - Lymph nodes, level 1 LN2  - Lymph nodes, level 2 6. SP: Level 1 and 2, right axillary contents with tags attached (am): Summary of Sections:. Part 1: Sp: Sentinel node #1, level 1, right axilla Block Sect. Site PCs 1 u 1 Part 2:  SP: Sentinel node #2, level 1, right axilla (fs) Block Sect. Site PCs 1 fsc 1 Part 3: Sp: Right breast mass Block Sect. site PCs 6 A 6 2 6 L 26 m 1 5 P 5 1 R 1 4 4 Part 4:  SP: Additional medial margin Block Sect. Site PCs 3 u Part 5: SP: Superior lateral tissue, right breast Block Sect. Site. PCs 3 Part 6: SP: Level 1 and 2, right axillary contents with tags attached. Block Sect. Site PCs 4 LNI 8 5 LNII 10 Intraoperative Consultation: ** Continued on next page
+
+--- Page 5 ---
+Nota: Page tissue sample examined at the time of the intraoperative consultation. 2) FROZEN SECTION DIAGNOSIS: POSITIVE FOR CARCINOMA. PERMANENT DIAGNOSIS: SAME. D S End of Report
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diff --git a/output/text/de1fb4f5-3cf1-4aef-95f5-f96a86ce0b71.txt b/output/text/de1fb4f5-3cf1-4aef-95f5-f96a86ce0b71.txt
new file mode 100644
index 0000000000000000000000000000000000000000..de87afa0e50ef87a55b876d7df266e70c3de3592
--- /dev/null
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+
+--- Page 1 ---
+Diagnosis: This material shows in I) parts of an invasive adenocarcinoma of the colon G2 with penetration of all parietal layers (pT3, L1, V1) and with free lymph nodes, in II) an additional adenocarcinoma, of moderate differentiation G2, with infiltration of the muscularis (pT2, L1, V1), as well as a tubular adenoma and a lymph node metastasis, thus corresponding to N1 (1 of 16).. Tumor classification: 1 ICDO-DA M-8140/3, G2, pT3, L1, V1, pN0 (0 of 24) II ICDO-DA M-8140/3, G2, pT2, L1, V1, pN1 (1 of 16)
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diff --git a/output/text/de4de4e5-0cdf-43f8-8c20-0266f523a524.txt b/output/text/de4de4e5-0cdf-43f8-8c20-0266f523a524.txt
new file mode 100644
index 0000000000000000000000000000000000000000..664bbf3f9eba9a961c212756bd58b1f3b17f53a3
--- /dev/null
+++ b/output/text/de4de4e5-0cdf-43f8-8c20-0266f523a524.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+******* MODIFIED REPORT - REVIEW ADDENDUM SECTION ******* DIAGNOSIS (A) CONTENTS SUBMENTAL TRIANGLE: Three lymph nodes, no tumor present (0/3) (B) CONTENTS RIGHT LEVEL 1: Two lymph nodes, no tumor present (0/2) (C) COMPOSITE RESECTION, TOTAL LARYNGECTOMY, TOTAL GLOSSECTOMY: INVASIVE SQUAMOUS CARCINOMA-Poorly-differentiated/basaloid Tumor Features: Size: 4 cm in largest dimension Invasion:Present, depth 0.65 cm Tumor Border: Broad nests Perineural Invasion: Absent Vascular Invasion: Absent Bone/ Cartilage Invasion: Tumor invades epiglottic cartilage (D) RIGHT DEEP PARAPHARYNGEAL: SQUAMOUS CARCINOMA PRESENT (E) RIGHT PARAPHARYNGEAL: SQUAMOUS CARCINOMA PRESENT. (F) LEFT PARAPHARYNGEAL: Squamous mucosa with mild dysplasia. No invasive carcinoma present. (G)RIGHT SUPERIOR PARAPHARYNGEAL: SQUAMOUS CARCINOMA PRESENT (H) LEFT SUPERIOR PARAPHARYNGEAL: Squamous mucosa, no tumor present. 1 RIGHT RETROMOLAR TRIGONE: Squamous mucosa, no tumor present. (J) RIGHT LATERAL PIRIFORM SINUS: Squamous mucosa, no tumor present. (K) LEFT LATERAL PIRIFORM SINUS: Squamous mucosa, no tumor present. (L) RIGHT UPPER ESOPHAGUS: Page 1of 4 Surgical Pathology Report File under: Pathology
+
+--- Page 2 ---
+Squamous mucosa, no tumor present. (M) LEFT UPPER ESOPHAGUS: Squamous mucosa, no tumor present. (N) POSTERIOR CRICOID: Squamous mucosa,no tumor present. (O) RIGHT PARAPHARYNGEAL: INVASIVE SQUAMOUS CARCINOMA, EXTENDING TO INKED TISSUE EDGE (P) RIGHT PARAPHARYNGEAL: Squamous mucosa, negative for tumor. (See comment) (Q) RIGHT SUPERIOR PARAPHARYNGEALSOFT TISSUE: Denuded squamous mucosa with no tumor present. COMMENT The intact tissue sections in part P are negative for invasive tumor. The overall findings favor an interpretation of no tumor present. GROSSDESCRIPTION A) CONTENTS SU3MENTAL TRIANGLE-A portion of yellow-tan adipose tissue measuring 3.5 x 2.1 x 1 cm.Five potential lymph nodes are found, ranging in greatest dimension from 0.3 to 0.6 cm. No tumor is seen grossly. SECTION CODE:A1, five potential lymph nodes;A2, remainder of specimen. (B)CONTENTS RIGHT LEVEL 1-A portion of adipose tissue measuring 4.1 x 3 x 1.5 cm.This measurement includes the salivary gland, which measures 3 x 1 x 1 cm. Three potential lymph nodes are found, ranging in size from 0.5 to 1 cm in greatest dimension. The salivary gland is serially sectioned and appears unremarkable. SECTION CODE: B1, three potential lymph nodes (one bisected.inked in blue); B2, adipose tissue from specimen (all adipose tissue is submitted); B3, representative portion of salivary gland *FS/DX: DETACHED FRAGMENT OF CARCINOMA IN FIBRIN (?CONTAMINANT) (C) COMPOSITE RESECTION,TOTALLARYNGECTOMY,TOTALGLOSSECTOMY-The e ngue8x7x3.5cm and attached larynx with attached first trachea ring (8 x 5 x 4 cm). There is an ulcerated lesion (4 x 3 cm),obliterating the base of the tongue, epiglottis, and pharynx bilaterally. An ill-defined tumor associated with the ulcer invades the base of tongue, hyoid bone, left inferior (ventral) surface of the tongue and soft tissue/ skeletal muscle deep to tongue at the neck. No tumor is identified within the larynx. Thyroid gland is not present. SECTION CODE:C1,C2, midline-tumor with base of tongue;C3,ulcerated region left;C4, ulcerated region right; C5 C6, ulceration with deep skeletal muscle extending to neck/chin region; C7,ulcerated tumor with epiglottis; C8,C9, additional ulceration bed; C10, para- laryngeal soft tissue; C11, left transglottic section:C12, right transglottic section C13, representative section of hyoid bone for decalcification. Page 2of 4 Surgical Pathology Report File under: Pathology
+
+--- Page 3 ---
+(D) RIGHT DEEP PARAPHARYNGEAL -A 0.5 x 0.5 x 0.4 cm fragment of mucosa entirely frozen in D. *FS/DX: SQUAMOUS CELL CARCINOMA. (E) RIGHT PARAPHARYNGEAL- Soft tissue (1.1 x 0.3 x 0.2 cm). Entirely frozen as E. *FS/DX: SQUAMOUS CELL CARCINOMA. F)LEFT PARAPHARYNGEAL-Soft tissue (1.1 x 0.3 x 0.2cm).Entirely frozen as F. *FS/DX: MILD SQUAMOUS DYSPLASIA, NO INVASIVE CARCINOMA (G) RIGHT SUPERIOR PARAPHARYNGEAL - Soft tisc 18x0.4 x0.4 cm.Entirely frozen as G. *FS/DX:SQUAMOUS CELL CARCINOMA. (H) LEFT SUPERIOR PARAPHARYNGEAL Soft tissue (1.1 x 0.3 x 0.2 cm).Entirely frozen as H. *FS/DX: NOTUMORPRESENT. (1) RIGHT RETROMOLAR TRIGONE - Soft tissue (1.1 x 0.3 x 0.2 cm). Entirely frozen as I. *FS/DX: NO TUMOR PRESENT J RIGHT LATERAL PIRIFORM SINUS-Soft tissue (1.0 x 0.8 x 0.3 cm).Entirely frozen as J *FS/DX: NO TUMOR PRESENT. (K) LEFT LATERAL PIRIFORM SINUS -Soft tissue 1.0 x 0.3 x0.2 cm.Entirely frozen as K *FS/DX: NO TUMOR PRESENT (L)RIGHT UPPER ESOPHAGUS -Soft tissue (0.5 x 0.2 x 0.2 cm). Entirely frozen as L *FS/DX: NO TUMOR PRESENT (M) LEFT UPPER ESOPHAGUS - Soft tissue (0.8 x 0.2 x 0.2 cm). Entirely frozen as M. *FS/DX: NOTUMOR PRESENT N) POSTERIOR CRICOID-Soft tissue 1.2 x 0.3 x 0.2 cm).Entirely frozen as N *FS/DX: NO TUMOR PRESENT (O) RIGHT PARAPHARYNGEAL, INK ON PT SIDE-A portion of irregularly shaped pink-tan soft tissue (2.7 x 1.3 x 0.5 cm). The area indicated as PT side is re-inked in blue and specimen is perpendicularly sectioned through this area and submitted in its entirety as O. (P) RIGHT PARAPHARYNGEAL- Soft tissue (1.1 x 0.3 x 0.3 cm).Entirely frozen as *FS/DX: DETACHED FRAGMENT OF CARCINOMA IN FIBRIN (? CONTAM (Q) RIGHT SUPERIOR PARAPHARYNGEAL SOFT TISSUE-Soft tissue (1.2 x 0.4 x 0.3 cm). Entirely frozen as Q *FS/DX:NO TUMORPRESENT CLINICAL HISTORY Tongue cancer SNOMED CODES 24100.T-5313 T-C4200, M-80703 "Some tests reported here may have been developed and performance characteristics determined by and Laboratory Medicine. These tests have not been specifically cleared or approved by the U.S. Food and Drug Administ Entire report and diagnosis completed by: Page 3 of 4 Surgical Pathology Report File under:Pathology
+
+--- Page 4 ---
+ADDENDUM This modified report is being issued to provide additional information/results COMMENT Additional sections reviewed following decalcification. In part C, the tumor also invades hyoid bone.. Entire report and diagnosis completed by: Page 4 of 4 Surgical Pathology Report File under: Pathology
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diff --git a/output/text/de57c689-861b-4af5-a2a8-f3b92ba0b196.txt b/output/text/de57c689-861b-4af5-a2a8-f3b92ba0b196.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1c986655bf78f9643569c7f05162db127fa8fc3e
--- /dev/null
+++ b/output/text/de57c689-861b-4af5-a2a8-f3b92ba0b196.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+ENTUM,RIGHT HEMICOLECTOMY DIADENOCARCINOMA OF THE CECUM (6.5 CM) ROUGHTHE MUSCULARIS PROPRIA INTO PERICECAL FAT WITH MULTIPLE ISOLATED NODEFINITIVE SEROSAL INVASION IS IDENTIFIED. TATTHE RADIAL PERICECAL SOFT TISSUE MARGIN AND INTRAVASCULAR TUMOR IS PROXIMAL MESENTERIC MARGIN (see comment). GIOLYMPHATIC, VASCULAR, AND PERINEURAL INVASION. OGIOF METASTATIC ADENOCARCINOMA ARE PRESENT ON THE SURFACE OF THE OMENTUM HEMUSCULARIS PROPRIA OF THE TERMINAL ILEUM. ILEUMAND DISTAL COLON MARGINS OF RESECTION ARE FREE OF CARCINOMA. STATIC ADENOCARCINOMA IN THIRTEEN OF TWENTY-THREE LYMPH NODES (13/23). SEPARATE.TUBULAR ADENOMA.  PATHOLOGIC STaGE: pT3c/d n2 m1. J.APPENDIX NOT IDENTIFIED. TCGA--AZ--4616 CASE SyNOPSIS:. SYNOPTICDATA- PRIMARY COLON, RECTAL, APPENDIX TUMORS SPECIMENTYPE: Right hemicolectomy SPECIMENLENGTH: 40 cm TUMOR SITE: Cecum TUMOR CONFIGURATION: Infiltrative Greatest dimension: 6.5 cm TUMOR SIZE: Additional dimensions: 6.0 x 5.5 cm INTACTNESS OF MESORECTUM: Not applicable. Adenocarcinoma HISTOLOGICTYPE: High-grade (poorly differentiated to undifferentiated) HISTOLOGIC GRADE: pT3c/d PATHOLOGIC STAGING (pTNM): pN2 Number of nodes examined: 23 Number of nodes involved: 13 pM1 Site(s): omentum, muscularis propria of ileum Treatment: Untreated Proximal margin uninvolved by invasive carcinoma Distal margin uninvolved by invasive carcinoma Circumferential (radial) margin involved by invasive carcinoma (tumor present 0-1 mm from CRM)  Mesenteric margin involved by invasive carcinoma Present ANGIOLYMPHATICINVASION: PERINEURAL.INVASION: Present TUMOR BORDER CONFIGURATION: Infiltrating None ADDITIONAL TUMOR CHARACTERISTICS: ADDITIONAL PATH FINDINGS (check all that apply): Adenoma(s)
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diff --git a/output/text/de90bcd1-240f-4fef-b738-fb11d99b304f.txt b/output/text/de90bcd1-240f-4fef-b738-fb11d99b304f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7c629f35dfd13d744d8808ccaa194aadbd42ed75
--- /dev/null
+++ b/output/text/de90bcd1-240f-4fef-b738-fb11d99b304f.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+E/txs8 BREAST TISSUE CHECKLIST Specimen type: Radical mastectomy Specimen size: Not specified "/e Tumor site: Breast Tumor size: 3.2 x 2.5 x 1.5 cm Grossly evident lesion: Yes b'090 Histologic type: Infiltrating ductal and lobular carcinoma Histologic grade: Tumor extent: Not specified Lymph nodes: 0/8 positive for metastasis (Regional 0/8) SON Extracapsular invasion of the lymph nodes: Not specified Right lower E-0-40 Margins: Not specified outer quasrant Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments:. None.
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diff --git a/output/text/decff6a4-2979-4cf4-aa11-59e0036cb7a2.txt b/output/text/decff6a4-2979-4cf4-aa11-59e0036cb7a2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..156f0b4d5a35f056bc5fc8aa23828e1fc9a52e35
--- /dev/null
+++ b/output/text/decff6a4-2979-4cf4-aa11-59e0036cb7a2.txt
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+
+--- Page 1 ---
+UUID:69DBF44F-F313-423E-8DD7-E3F80AE87588 Requesting Doctor's Information: TCGA-OR-A53K-01A-PR Redacted LcD-6-3 scindu Adreuab CrhcaJ 83%)a Site:::Adreual:Slaws eortes C74.D rs AO 1I313 A SPECIMEN TYPE: Adrenal T CLINICAL NOTES: H En Bloc resection of Lt ACC + left kidney. Tumour thrombus in Lt renal vein. 0 Biopsy of tumour for genetics studies. L MACROSCOPIC: 0 The specimen consists ot an en block resection of kidney, adrenal, renal vein G and surrounding tat. The kidney is 120x 80 x 60mm. Medial and superior to the kidney there is a mostly encapsulated tumour, 140 x 130 x 110mm. The Y tumour does not invade into the kidney parenchyma but is separated trom the kidney by a narrow rim of fatty tissue. On sectioning, there is foca! extension through the tumour capsule into the surrounding perinephritic fat, up to 13mm in depth. The tumour also invades directly into the adjacent rena! vein forming a nodular tumour mass, 30 x 20 x 20mm in the vein lumen. The stapled resection margin of the renal vein appears abutted by the tumour mass. The cut surface of the tumour has a yellow/tan neterogenous appearance. It is variegated and haemorrhagic in areas. The tumour weighs 826g. The adjacent kidney appears normal on sectioning. At the hilum the artery 3omm in length, renal vein 7omm in length, and ureter 5Omm in length are identified. The renal A vein is involved as described previously, No lymph nodes are found despite careful examinatlon ot the peri-renal and peri-adrenal tissue.. N Block 1: renal vein margin with tumour thrombus. Block 2: ureteric and renal artery margins A Blocks 3,4: tumour invading through capsule and extending into perinephritic T fat Blocks 5-7: further tumour invading directly into renal vein 0 Blocks 8-11: further tumour from variou$ areas. M Block 12: normal kidney 1 c MICROSCOPIC: The 826g 140 mm tumour is a high grade adrenal cortical carcinoma. The A carcinoma displays 8 ot the 9 Weiss criteria of malignancy. It is composed predominantly ot pleomorphic cells with eosinophilic cytoplasm. There is L extensive coagulative necrosis and some of the necrotic areas show dystrophic calciication. There is sinusoidal and venous invasion and, as described macroscopically, a 30 mm tumour thrombus is present in the renal vein. The P mitotic rate is 4 mitoses per 50 hpt. Occasional atypical mitoses are present. A The tumour is mostly well circumscribed but does show extra-adrenal spread. The tumour abuts the renal vein margin. It is separated from the soft tissue T resection margins by intact tissue planes indicating that all other margins are H 0 L n
+
+--- Page 2 ---
+Requesting Doctor's Information: A SPECIMEN TYPE: Adrenal T h clear. 0 The adjacent non-neoplastic adrenal gland is normal. The kidney also shows no L histological abnormality. 0 Immunohistochemistry is as follows: G IGF-2: Diffuse strong positive staining (with perinuclear dot-like positivity) Glucocorticoid receptor: Positive (score 2+) Y Ki-67 proliferative index: 5% SUMMARY: Left adrenal gland and kidney: Adrenal cortical carcinoma 140mm. A N REPORTING PATHOLOGIST: A (Electronic Signature) T 0 M 1 c A L P A T H 0 L Page 2 ot 2 0 G Y Where Collected' Indicates Rec:
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diff --git a/output/text/ded29231-9a25-4427-a9b8-ab9e3fc4c0ce.txt b/output/text/ded29231-9a25-4427-a9b8-ab9e3fc4c0ce.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fd30ec0a0ef7eebacda5d11b61e8c1a1b6134ffb
--- /dev/null
+++ b/output/text/ded29231-9a25-4427-a9b8-ab9e3fc4c0ce.txt
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+
+--- Page 1 ---
+3Do-3 Corcroms,droThliol NsS 8/20/3 Sample # Site: Mstrr wally Gender: Female bladder Cs74 DOB: Race: White XJ 7/22/13 Report Date: Pathology Report: Redacted Surgical Pathology Report FINAL PATHOLOGIC DIAGNOSIS A. Urinary bladder; radical cystectomy, anterior vaginectomy and right.  salphingo-oophorectomy: - Bladder with invasive high-grade urothelial carcinoma, invading through the muscularis propria, and into the perivesicular fat and vaginal wall, see. pathologic parameters. - Urothelial carcinoma in-situ involving bladder dome and posterior wall. mucosa. - Ovary with age-related changes. - Fallopian tube, no tumor. - Margins, free of tumor. B. Right pelvic lymph nodes; dissection: - Eight lymph nodes, no tumor (0/8). C. Left pelvic lymph nodes; dissection: - Eight lymph nodes, no tumor (0/8). D. Left distal uretheral margin; excision: - Portion of ureter, no tumor. E. Right distal ureter; excision: - Portion of ureter, no tumor. Urothelial Carcinoma Pathologic Parameters 1. Tumor type: Invasive urothelial carcinoma. 2. Grade of tumor: High grade. 3. Depth of invasion: Adjacent organ: Vaginal wall. 4. Tumor distribution: Solitary, 2.5 cm, posterior bladder wall extending to perivesical fat and vaginal wall. 5. Ureteral margins: Negative for tumor. 6. Distal urethral margin: Negative for tumor.
+
+--- Page 2 ---
+7. Soft tissue margin or serosa: Negative for tumor. 8. Lymph nodes: Negative for tumor (0/16). 9. pTNM: pT4a,N0,MX Effective January 1, 2010 this Checklist utilizes the 7th edition TNM staging system for Bladder of the American Joint Committee on Cancer (AJCC) and the International Union Against Cancer (UICC). Interpretation performed by the Attending Pathologist and reviewed with the Resident/Fellow, [], MD, PhD Electronically Signed Out by [] MD Clinical History: Patient is a  year-old female clinical history of bladder cancer who undergoes cystectomy, ileo conduit N. retroperitoneal lymph node dissection.. Specimens Received: A: Bladder B: Right pelvic lymph nodes C: Left pelvic lymph nodes D: Left distal uretheral margin E: Right distal ureter Gross Description: The specimens are received in five containers each labeled with the patient's name and medical record number. A. The first container is additionally identified as, "bladder". Received fresh and place in formalin is a 145.08 g cystectomy specimen with overall. measurements of 12.5 x 11.0 x 3.7 cm. The right ureteral stump measures 3 cm in length and 0.4 cm in diameter, and the left measures 2.5 cm in length and 0.7 cm in diameter, and both demonstrate intact patent lumens. The serosal surface shows yellow, lobulated fibroadipose tissue with focal cautery artifact. There is a 2.5 x 2.0 x 1.5 cm matted area on left posterior bladder held together by a suture which is removed to reveal a 1.6 x 0.9 cm defect and a 4.0 x 3.5 cm area of peritoneal discoloration on the right side adjacent to the dome. There is a 7.4 x 7.0 cm portion of tan-pink vaginal mucosa fixed on the posterior aspect of the bladder. The urethral margin is inked black, and the bladder is inked blue on the right half and black on the left half. The bladder measures 6.0 x 5.5 x 2.5 cm. The specimen is opened anteriorly to reveal a 2.5 x 1.7 cm red-tan,  hemorrhagic, friable, ulceration located in posterior wall within an ill-defined
+
+--- Page 3 ---
+4.1 x 3 cm area of induration. On cut section, the mass is white-tan, indurated, and extends through the muscularis propria and pericystic adipose tissue and abuts the deep surgical margin (i.e. 2.5 cm of 2.6 cm of the total thickness of the specimen). Inferiorly, the induration also appears to abut the vaginal wall. The surrounding bladder mucosa is wrinkled, congested, pink-tan with a uniform 0.5-0.9 cm wall thickness. Bilateral ureteral orifices, adjacent to the trigone, are identified and probe patent.. Representative sections are submitted as follows:. A1: Left ureter A2: Right ureter A3: Urethral margin A4: Uninvolved bladder mucosa anterior wall A5: Uninvolved bladder mucosa posterior wall. A6: Uninvolved bladder mucosa bladder dome. A7-A10: Bladder mass/Ulceration A11-A13: Bladder mass abutting the vaginal wall A14 Fallopian tube A15-A16 Ovary B. The second container is additionally identified as, "right pelvic lymph nodes". Received fresh and placed in formalin is a 5.0 x 4.5 x 0.9 cm aggregate of soft, rubbery, yellow-tan tissue fragments that are dissected for approximately 10 lymph node candidates are submitted as follows B1: Two lymph node candidates B2: One lymph node candidates, bisected B3 B4: One lymph node candidates, bisected, one half in each cassette B5: Five lymph node candidates B6: One lymph node candidates, bisected C. The third container is additionally identified as, "left pelvic lymph nodes". Received fresh and placed in formalin is a 4.0 x 3.5 x 1.1 cm aggregate of soft, rubbery, yellow-tan tissue fragments that are dissected for approximately 9 lymph node candidates are submitted as follows. C1: Five lymph node candidates C2: One lymph node candidates, bisected C3: One lymph node candidates C4: One lymph node candidates, bisected. C5-C6: One lymph node candidates, bisected, one half in each cassette D. The fourth container is additionally identified as, "left distal ureteral margin stitch on margin side ". Received in formalin is a 2.3 cm in length by 0.9 cm in external diameter segment of ureter. There is a stitch on the non-margin side. The serosal surface of the margin side is inked black. The margin side of the ureter and a representative section are submitted in cassette D1.
+
+--- Page 4 ---
+E. The fifth container is additionally identified as, "right distal ureter, stitch on margin side". Received in formalin is a 2.9 cm in length by 0.5 cm in external diameter segment of ureter. The non-margin side is indicated with a suture. The margin side is inked black and is submitted with a representative section of the ureter in cassette E1.
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diff --git a/output/text/dee3ff48-8e01-4068-a245-4e442258650e.txt b/output/text/dee3ff48-8e01-4068-a245-4e442258650e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0f7cac3b3ec1e275099128c58420f3e724450ecd
--- /dev/null
+++ b/output/text/dee3ff48-8e01-4068-a245-4e442258650e.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+DIAGNOSIS: 1. Mass, right kidney (partial nephrectomy): Renal cell carcinoma, papillary type I; incipient lesion is seen in adjacent kidney parenchyma, see note. 2. Fat, overlying tumor (excision): Fibroadipose tissue, no tumor seen.. NOTE: Kidney Partial Nephrectomy Summary Table. Macroscopic Specimen Type: Partial nephrectomy Laterality: Right Tumor Size: 5.5 x 4.2 x 2.3 cm Focality: Unifocal with adjacent incipient lesion Macro Extent of Tumor: Limited to the kidney Microscopic Histologic Type: Renal cell carcinoma, papillary type I. Extent of Invasion Primary Tumor(pT): pT1b Regional Lymph Nodes(pN): pNX Distant Metastisis(pM): pMX Margins: Can not be assessed. CLINICAL INFORMATION: Brief Clinical History: with bilat multifocal tumors Patient Identification
+
+--- Page 2 ---
+Specimen Taken For Protocol:. PRocEDuRE: Pre-Operative Diagnosis: Bilateral renal masses Post-Operative. Diagnosis: Bilateral renal masses Operative Findings: 3 cm R upper pole tumor with satelite lesion SPECIMENS SUBMITTED: 1. KIDNEY, RIGHT, Mass 2. FAT, Overlying tumor. GROss DEscRiPTION: Received are 2 formalin-filled containers labeled with the patient's name, medical record number, and further described as follows: 1. "Right kidney mass". Received fresh from OR labeled with the patient's name, medical record number and "right kidney mass" is a 5.5 x 4.2 x 2.3 cm, tan, friable tumor, with a small rim of normal parenchyma, a second nodule measuring 0.5 x 0.4 cm is present. Approximately 50% of both tumors and 5 mL of normal kidney parenchyma procured for Research. Macroscopic images were taken. The procurement was performed by Received in Surgical Pathology, the specimen is serially sectioned and representative sections are submitted in white cassettes labeled through 1D for serial. sectioning. 2. "Fat overlying tumor". The specimen consists of 2 pieces of yellow adipose tissue measuring 3.5 x 3 x 0.5 cm in aggregate. The specimen is serially sectioned and no gross tumor identified. The specimen is entirely. submitted in white cassettes labeled through 2E for serial sectioning..
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diff --git a/output/text/defd0d15-89eb-41d9-a20c-1179db0e620c.txt b/output/text/defd0d15-89eb-41d9-a20c-1179db0e620c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9df40e0b720b50e568d9a6e59b87c8f01136f55a
--- /dev/null
+++ b/output/text/defd0d15-89eb-41d9-a20c-1179db0e620c.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+jcD-0- 3 C aNnonra infci+rxtiNg ductal, Nos 8Se0/3 c.50.9 t : Phone Fax Specimen: Recaived: Status: Req#: Spec Type: SURGICAL P Subm Drs RIGHT BREAST CANCER - INVASIVE UUID:0284C31 81E-38F0-4AF3-8DAD-527D5F27C11A TCGA-A2-A1G6-01A-PR Redacted Date: DOctor(s) : PRockdure : A. RIGHT MODIFIED RADICAL MASTECTOMY B. MEDIAL SKIN RIGHT BREAST PART A IS RECEIVED LABELED RIGHT MODIFIED RADICAL MASTECTOMY STITCH MARKS 12 O'CLOCK, IS A RIGHT MODIFIED RADICAL MASTECTOMY SPECIMEN MEASURING 26 X 18.5 X 5.5 CM IN GRKATEST DIMENSIONS. THE NIPPLE IS UNREMARKABLE AND IS WITHIN A 19 X 11.7 CM SKIN ELLIPSE. THE 5 TO 6 O'CLOCK AREA AT THE INFERIOR MARGIN THERR IS A 3 CM IN IN DIAMETER CYSTIC STRUCTURE. THE SKIN HAS A BROWN DISCOLORED PLAQUE-LIKE AREA AT 12 O'CLOCK. THERE IS A PALPABLE FIBROUS MASS IN THE BREAST TISSUE BENEATH THE SUTURE SPANNING A DISTANCE OF 6 X 5 X 3.5 CM. THE SUPERFICIAL ASPECT IS MARKKD WITH BLUE INK, THE DEEP MARGIN WITH BLACK.  THE AXILLARY TAIL IS REMOVED FROM THE SPECIMEN AND WHERE IT IS REMOVED IT IS MARKED WITH RED INK AND DOES NOT REPRESENT TRUE MARGIN. THERE IS ONE GROSSLY POSITIVE LYMPH NODE IN THE MIDPORTION OF THE AXILLARY TAIL. THE HIGHEST NODE GROSSLY IS NEGATIVE.  SECTIONS ARE SUBMITTED AS FOLLOWS: A1--NIPPLE, A2--ONE-HALF OF A GROSSLY POSITIVE LYMPH NODE (REMAINDER SUBMITTED PER PROTOCOL). A3--GROSSLY HIGHEST LYMPH NODE, A4--ONE LYMPH NODE BISECTED, A5--ONE LYMPH NODE BISECTED, A6--ONE LYMPH NODE. A7--TUMOR AND DEEP MARGIN, A8 AND A9--TUMOR AND SKIN ADDING TO A8 AN AREA OF COIL CLIP, A1O--TUMOR AT INFERIOR ASPECT ADJACENT TO FIBROUS TISSUE, A11--TISSUE IMMEDIATELY ADJACENT TO TUMOR UPPER INNER QUADRANT, A12--TISSUE IMMEDIATELY ADJACENT TO TUMOR UPPER OUTER QUADRANT, A13--ADDITIONAL UPPER OUTER QUADRANT, A14--LOWER OUTER QUADRANT 4.5 CM FROM GROSS TUMOR, A15--LOWER INNER QUADRANT 3 CM FROM GROSS TUMOR, Al6--CYSTIC STRUCTURE IN 5 O'CLOCK AREA.  THE AXILLARY TAIL IS THEN FURTHER EXAMINED FOR LYMPH NODES, WHICH ARE SUBMITTED AS FOLLOWS: A17--ONE NODE BISECTED, A18--ONE BONE BISECTED, A19--ONE NODE BISECTED, A20--ONE NODE BISECTED. ASSOCIATED WITH THE PLAQUE-LIKE AREA OF THE SKIN IS AN UNDERLYING FIRM PINK-GRAY MASS MEASURING 3.5 X 3.3 X 3.1 CM IN GREATEST DIMENSIONS. GROSSLY THIS EXTENDS TO WITHIN O.8 CM OF THE DEEP MARGIN.  THE CENTRAL PORTION OF THE BREAST ALSO DEMONSTRATES DENSE GRAY-TAN FIBROUS TISSUE WITH MULTIPLE CYSTS. ADDITIONAL SECTIONS ARK SUBMITTED AS FOLLOWS FOLLOWING INITIAL REVIEW OF SLIDES: A21 AND A22--SKIN MARGIN, A23--SUPERFICIAL MARGIN.
+
+--- Page 2 ---
+Specimen:d Received:d Status: Spec TYpe: SURGICAL P Reg! Subm Drt (Continued) PART B IS RECEIVED MEDIAL SKIN RIGHT BREAST.  IT CONSISTS OF AN UNORIENTED, SOMEWHAT TRIANGULAR PORTION OF SKIN NITH UNDERLYING SUBCUTANEOUS TISSUE, APPROXIMATELY 2 X 1 X 1 CM. THE RESECTION IS INKED. THE SPECIMEN IS SECTIONED AND KNTIRELY SUBMITTED IN CASSKTTES B1 AND B2. pRocedures : 88305, 88309, A BLK/23, B BLK/2 PART A /RIGHT MODIFIED RADICAL MASTECTOMY: IN SITU AND INFILTRATING DUCTAL CARCINOMA. THE INFILTRATING TUMOR IS MODERATELY DIFFERENTIATED, NUCLEAR GRADE III/III WITH A MODERATE MITOTIC INDEX. THE SUPERFICIAL ASPECT OF THE TUMOR EXTENDS INTO THE DERMIS.  THE DEEP MARGIN IS FREE OF TUMOR BY A DISTANCE OF 10 MM FOR A SUPERFICIAL TO DEEP SIZE OF 35 MM. OVER 9Ot OF THE TUMOR IS INVASIVE. AREAS OF PROBABLE BREAST LYMPHATIC SPACE INVASION ARE PRESENT BUT DERMAL LYMPHATIC SPACE INVASION IS NOT IDENTIFIED. BREAST TISSUE AWAY FROM THE PRIMARY TUMOR MASS SHONS PROLIFERATIVE FIBROCYSTIC DISEASE. SKIN MARGINS CLOSEST TO THE TUMOR ARE NEGATIVE.  METASTATIC CARCINOMA IS PRESENT IN 4 OF 9 LYMPH NODES. PART B  MEDIAL SKIN OF RIGHT BREAST, RESECTION: SKIN AND SUBCUTANEOUS FAT WITH NO EVIDENCE OF MALIQNANCY. 1 Signed (prelim.) (signature on file) DISQUALED
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diff --git a/output/text/df4f4288-8592-48a2-ba3b-8817e7417f2d.txt b/output/text/df4f4288-8592-48a2-ba3b-8817e7417f2d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4d205483bac091e02a0c8b87264906e1f3290e01
--- /dev/null
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+
+--- Page 1 ---
+FINAL DIAGNOSIS: Collection Date: Breast, Left, total mastectomy (120.1 grams) -- A. MetapLAStIc CArciNoma OF thE BrEaSt, SpInDLe CELl TypE, nOTTInghAm graDe Il (TuBuLE FORMATION 3, NUCLEAR PLEOMORPHISM 3, mITOTIC ACTIViTY 1; TOTAL SCORE 7/9). B. THe InVasive Tumor mEASureS 3.8 Cm In GREaTeSt DImenSIOn. C.  NO LYMPHOVASCULAR SPACE INVASION IS NOTED. D.  INKED MARGINS ARE NEGATIVE FOR CARCINOMA; HOWEVER, A FOCUS OF INVASIVE CARCINOMA IS LESS  MM (LESS THAN 0.1 CM) FROM THE ANTERIOR INKED MARGIN. E. THE INVASIVE CARCINOMA IS LOCATED IN THE CENTRAL AREA F. THE NIPPLE DERMIS AND ADJACENT SKIN DERMIS, BUT NOT THE EPIDERMIS, ARe INVOLVED BY INVASIVE CARCINOMA G NIPPLE DUCTS WITH SQUAMOUS METAPLASIA. H.  PreVIous biopSy SITe changES. The invasive tumor CeLls are negative for estrogen receptor, weakly positive fOr PROgESTERONe RECEPTOR, AnD NEGaTIVe fOR hER-2, AS pER PREVIOUS PATHOLOgy REPORT (see comment).  NON-NEOPLASTIC BREAST WITH RADIAL SCARS. COMMENT:  hormone Due to the weakly positive PR result on the core biopsy based on stains performed at. receptor immunohistochemistry will be repeated and an addendum will follow.. Addendum ** BREASt TUmOr ImmUnOhIStOLOgy RESULTS** HORMONE RECEPTOR IMMUNOHISTOCHEMISTRY RESULT H SCORE RAW IMMUNOSTAINING SEMIQUANTITATION ER: Weakly positive 10 (0: 91t; 2+: 1%; 3+: 0%) PR: 0 (0: 100%; 1+: 0%; 2+: 0%; 3+: 0%)  Negative ESTROGEN/PROGESTERONE RECEPTOR$.(ER/PRL TEST DETAILS: Using formalin fixed tissues (8-96 hours) and appropriate positive and negative internal/external controls; the test for the presence of hormone receptor protein is performed by the immunoperoxidase method according to the AsCO-CAP Guidelines. A positive Estrogen or Progesterane receptor tumor shows nuclear immunostaining in greater than or equal to 1% of the tumor cells (i.e. and H-score of 1 or higher). The ER and PR. Histologic Score (H-Score, or HS) is calculated as the sum of intensity of staining times the proportion of cells staining and has a. dynamic range of 0 to 300. The semiquantitation immunostaining raw data used to calculate the H-score is also shown above in. the report. Generally, the H-score correlates to percentage of positive cells. According to. the correlation of mean H-score versus percent cells staining for ER is as follows: H-score of 251 (>75% cells staining): H-. score of 130 (51-75% cells staining); -score of 42 (10-50% cells staining): H-score of 4 (<10% cells staining). Estrogen receptor antibody SP1, an IVD, is performed using the Progesterone receptor antibody 1E2, an IVD, is performed using the C&CF tCDO3 metsplostie, ducts bi... irone UUID:1DB8FAFB-FC4A-4401-8316-30FB5352335D C850l3 85753 tcga-bh-a6r9-01a-pr Redacted Crde tB highiot j 8676/3 (8525 J3) (8032/3 Cedle ts JughesF 8575/3 C6C# See DY3usss+No5 C5o.9 OYBuost, csntisIpootion C5O.1 JtJ 8/2/13
+
+--- Page 2 ---
+CASE SYNOPSIS: SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST LAteraLity: PROCEDURE: Left Simple mastectomy LOCATION: Central subareolar SIZE OF TUMOR:  Maximum dimension invasive component: 38 mm. MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: No TUMOR TYPE (invasive component): Metaplastic carcinoma NOTTINGHAM SCORE: Nuclear grade: 3 Tubule formation: 3 Mitotic activity score: 1 Total Nottingham score: 7 Nottingham grade (1, 2, 3): 2 ANGIOLYMPHATIC INVASION: No DERMAL'LYMPHATIC INVASION: No CALCIFICATION: No SURGICAL MARGINS iNVOLVED BY INVASIVE COMPONENT: No Distance of invasive tumor to closest margin: 1 mm. PAgET'S DISEASE OF NIPPLE: No LYMPH NODES EXAMINED: 0 METHOD(S) OF LyMPH NODE EXAMINATION: Other: None.  SKIN INVOLVED (ULCERATION):S No t stage, pathologic: pT2 N stage, pathologic: pNX M STAGE:  Not applicable ESTROgeN RECepTOrS: negative PROGESTERONE RECEPTORS:E positive, H-score: 60 HER2/NEU: 0 MICROSCOPIC: Block 1B: Antibody/Antigen Result Vimentin Positive S-100 Rare weakly positive cells. CK5 Positive. AE1/AE3 Weakly positive. CK17 Positive. P63 Positive. CK14 Positive. Block 1C: Antibody/Antigen Result P63 Highlights tumor cells and myoepithelial cells. Smooth muscle myosin heavy chain Highlights myoepithelial celis. performed with the following selected antibodies and designated antibody clone(s). directed against the following antigenic target(s), with adequate positive and negative internal and external controls. Antibodies are optimized appropriate for fixation times. ANTIBODY CLONE TARGET ANTIGEN Vimentin VENDOR V9 Mesenchymal cells S-100  Polyclonal Rabbit  Melanoma screen CK 5 XM26 High molec wt keratin AE1/AE3 AE1/AE3 CK 17 carcinomas E3 High molec wt keratin p63 4A4 Myoepithelial cells CK 14 LL002 High molec wt keratin Myosin SMMS-1 Myoepithelial cells DISQUALIFIED edR
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diff --git a/output/text/df4f73dc-9afb-4592-8135-20ac14f40c99.txt b/output/text/df4f73dc-9afb-4592-8135-20ac14f40c99.txt
new file mode 100644
index 0000000000000000000000000000000000000000..30c1a3dfc47b1ec88dbf12c1a726dbaf422d34b4
--- /dev/null
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+
+--- Page 1 ---
+tcD-6-3 avcino mc, ena) cel Ch^omophebe tpe 8317|3 Site DKidney NsS Cb4.9 AO kx/Q4 112 Sex: Male D.O.B: MRN UUID:F5F1532B-759D-4195-8C33-33C1D6DF8F25 TCGA-NP-A5H6-01A-PR Redacted Accession #: Acct / Reg SURGICAL PATHOLOGY REPORT DIAGNOSIS  DIAGNOSIS: Left kidney, radical nephrectomy: Tumor Characteristics: . Histologic type: Renal cell carcinoma, chromophobe type. 2. Tumor site: Lett kidney, upper pole. 3. Tumor tocality: Unifocal. 4. Tumor size: 8.0 x 6.5 x 6.0 cm.. 5. Macroscopic/microscopic extent of tumor: Turmor is conlined to the kidney; with no evidence of transcapsular or perinephric soft tissue invasion. 6. Nuclear grade: Fuhrman grade 3-4/4. 7. Lymphovascular space invasion: No. 8. Sarcornatoid features: No. Surglcal Margin Status: 1. Vascular, ureteral. and perinephric margins are all negative for tumor. Lymph Node Status: No lymph nodes are identified with the specimen. Other: 1. TNM stage: T2a NX MX. Electronic Signature: COMMENTS:  Representative sections of this tumor have also been reviewed concurs with the diagnosis. CLINICAL INFORMATION CLINICAL HISTORY: Preoperative Diagnosis: Abdominal mass, unspecified site Postoperative Diagnosis: Symptoms/Radiologic Findings: SPECIMENS: Left kidney SPECIMEN DATA GROSS DESCRIPTION: The specimen is received labelet Ioft kidney. The specirnen consists of a kidney with attached perinephric fat that measures 28.0 x 16.0. x 7.5 cm, and weighs 110t gm. Tnere is no adrenal gland attached to the specimen. The ureter measures 10.0 cm in length and up to 0.5 cm diameter.  The surtace is gray-tan to brown-tan. On opening the ureter, the mucosal surtace is light tan and reveals normal mucosal folds. There is no material or lesions identitied. The renal artery measures 2.5 cm in length and 0.5 cm in diameter and is grossly unrernarkable. The renal vein rneasures 2.0 crn in Iength and up to 1.0 cm in diameter, and is likewise grossly unremarkable. At the hilum, there are no lymph nodes identified. The sott tissue resected rnargin is yellow to brown-tan with slight adhesions. The margin is inked. The kidney is bisected and reveals a circumscribed brown-tan to yellow-tan hemorrhagic mass within the upper pole measuring 8.0 x 6.5 x 6.0 cm. On sectioning, the mass appears grossly contined to the capsule. There is no invasion into the surrounding perinephric tat. The mass comes within 0.1 cm ot the inked resected margin. The mass does not invoive the renai calices or pelvis. The lining of the renal calices and pelvis is gray-tan, unremarkable. The surrounding renal cortex neasures up to 1.0 cm, is brown-tan. ang shows a well-dernarcated corticomedullary junction. There are no other lesions identified grossly. Received with the specimen are three cassettes, ono green, one yellow and one blue, labeled  with the yellow additionally labeled -16, the green additionally labeled -17, and the blue. additionally labeled -18. Representative sections are submitted in cassettes labeled. as follows:sections from the mass 14ureter-5 renal artery and vein -- 6; surrounding uninvolved kidney -- 7. Criteria Diagnosis Dicrep rimary mor Site Discrepan
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diff --git a/output/text/df558174-cd36-4d74-98d4-1013409d0b8d.txt b/output/text/df558174-cd36-4d74-98d4-1013409d0b8d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..97c9c7fb5a81f8198d5a0fe8b01e274fd8961ad9
--- /dev/null
+++ b/output/text/df558174-cd36-4d74-98d4-1013409d0b8d.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:2972AB07-2C29-43B8-96DA-1386C5E248EB0 TCGA-A2-A0CM-01A-PR Redacted PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: FMP/SSN: DOb/Age/Sex: Race: BLACK Taken: Location: Received: Physician(s) : Reported: **AMENDED** /CS-0-3 Carcnona, wfitrstnz outal nrs 8500f3 SPECIMEN: LEFT BREAST MASS Si#: brastNos C50.9 1f24|n jw FINAL DIAGNOSIS: BREAST, LEFT, BIOPSY: POORLY DIFFERENTIATED INVASIVE DUCTAL CARCINOMA (GRADE III/III PER MODIFIED BLOOM RICHARDSON GRADING) WITH EXTENSIVE NECROSIS. TUMOR SIZE = 3.0 CM (MEASURED GROSSLY). MINIMAL IN-SITU COMPONENT (HIGH GRADE). LYMPHVASCULAR SPACE INVASION IS IDENTIFIED. TUMOR EXTENDS TO WITHIN 1 MM OF THE DEEP SURGICAL MARGIN. HYALINIZED FIBROADENOMA. COMMENT : Dr. was notified of the above diagnosis via e-mail on ESTROGEN AND PROGESTERONE RECEPTORS WERE PERFORMED. THE TUMOR IS NEGATIVE FOR ESTROGEN RECEPTORS AND FOCALLY POSITIVE FOR PROGESTERONE RECEPTORS. HER2/neU BY IMMUNOHISTOCHEMISTRY (HERCEPTEST) : NEGATIVE (O+). Renort Electronically Signed Out ** CLINICAL DIAGNOSIS AND HISTORY: {None Given}. GROSS DESCRIPTION: LEFT BReAsT MAss received fresh and consists of a fibrofatty tissue fragment measuring 8.0 x 2.5 x 2.3 cm. The deep margin is designated with a suture. The deep margin is inked black, while the remainder of the specimen is inked blue. At the deep margin there is a firm, well-circumscribed mass measuring 3.0 x 2.5 x 2.5 cm with a tan, gritty, and focally hemorrhagic cut surface. The remaining tissue is predominantly Page 1 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 2 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient:. Specimen #: GROSS DESCRIPTION (continued) : fatty and unremarkable. Multiple sections of tumor and grossly normal. breast tissue are harvested for cbcp protocol. Mirror images for histology are as follows:. Al-Tumor. A2-Tumor. A3-Gross norma1 Additional sections are as follows:. A4-10-Tumor. A11-12-Gross normal. Page 2 End of Report FOR OFFICIAL USB ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
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diff --git a/output/text/df5ff237-957c-4216-8042-d8053e57f45a.txt b/output/text/df5ff237-957c-4216-8042-d8053e57f45a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..abd26f4fa580f02f0704238eed0e1cf43cadf305
--- /dev/null
+++ b/output/text/df5ff237-957c-4216-8042-d8053e57f45a.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Icp-0-3 8503fj (invasive) S,tx. buwt.nos c50.9 3111| page 1 / 2 Department of Cancer Pathology copy No. Date: Examination: Intraoperative examination Internal invoice No. Cost of diagnostic procedure Examination No.: Patient: xxx PESEL: XXX Age: Gender: F Material: Multiple organ resection -- right breast. Unit in charge:. Physician in charge: Material collected on Material received on: ' Expected time of examination: 20 minutes (from receipt of the material) Clinical diagnosis: Suspected cancer of the right breast. Lesion on the boundary of the upper quadrants. Examination performed or Result of intraoperative examination: UUID: 0EA57ABF-E3DA-4862-BAB8-A6E36408AC42 Carcinoma probabiliter invasivum. TCGA-D8-A13S-01A-PR Redacted Final diagnosis after paraffin specimens are analysed. Compliance validated by:  Examination performed on: Macroscopic description: Surgical specimen sized 5 x 4 x 2 cm with a skin flap of 4 x 0.5 cm. Minimum side margin 0.2 cm. Result of intraoperative examination: Carcinoma papillare probabiliter invasivum. Foci Dcis typus cribrosus cum atypia gradus levioris ad mediocrum sine necrosis. Final diagnosis after immunohistochemical tests. Compliance validated by: Examination performed on: Results of immunohistochemical examination: Estrogen receptors found in over 75% of neoplastic cell nuclei.  Progesterone receptors found in over 75% of neoplastic cell nuclei. HER2 protein stained with HercepTestTM by DAKO. Negative reaction in invasive cancerous cells ( Score = 0 ) Compliance validated by: Examination performed on:
+
+--- Page 2 ---
+page 2 / 2 Examination: Intraoperative examination Examination No. Patient: xxx PESEL: XXX Gender: F Examination performed on: Histopathological diagnosis: Carcinoma papillare probabiliter invasivum NHG1 (2 + 2 +1/0 mitoses/ 10 HPF, visual area diameter: 0.55 m). Corresponds to invasive papillary carcinoma of the right breast. Solitary foci of Dcis (cribrate type with medium nuclear atypia, without necrosis). The immunohistochemical test showed the absence of a myoepithelial cell stratum around the foci of the invasive lesion (p63-, SMA'). The cells show negative reaction withck5/6. Cytokeratin 7 present in part of the cells. Compliance validated by:. Examination performed on: Suplementary test Expression of the Ki67 proliferation antigen showed in 5% of cellular nuclei (20% in hot spots) Compliance validated by
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diff --git a/output/text/df602b43-18a3-46da-9c20-e6618f8cf04d.txt b/output/text/df602b43-18a3-46da-9c20-e6618f8cf04d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0c804717628eb2c40a24c69c9e4c4eb481e7e06f
--- /dev/null
+++ b/output/text/df602b43-18a3-46da-9c20-e6618f8cf04d.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:F0E3A01E-2B43-4BE1-BAE5-85340943A422 TCGA-FD-A3B3-01A-PR Redacted Surgical Pathology Report FINAL PATHOLOGIC DIAGNOSIS A.  Right pelvic lymph nodes; dissection:  Four 1ymph nodes, no tumor present (0/4).. B. Left pelvic lymph nodes; dissection: - Four 1ymph nodes, no tumor present (0/4). C. Bladder;' cystectomy:  Papillary urothelial carcinoma, high grade, with squamous differentiation, transmurally invasive into perivesical adipose tissue. ' Muitifocal urotheliai carcinoma in-situ' (flat urothelial carcinoma). - No lymphovascular invasion present. - Margins of resection (soft tissue, urethra, right and 1eft ureter), no tumor present. Urinary bladder mucosa with ulceration, necrosis, inflammation and multinucleated giant cell reaction consistent with previous biopsy site. See pathologic parameters. D. Ovaries; oophorectomy:. Ovaries with no significant pathology.  Fallopian tubes with paratubal cysts. E. Right ureter segment; excision: Segment of ureter,'no tumor present. Urothelial Carcinoma Pathologic Parameters. Tumor type: Papillary and flat urothelial carcinoma ics-0 -3 Grade of' tumor: High grade 3. Depth of invasion: Perivesical adipose tissue. Carcinonr, prpillny wrothhisl 4. Tumor distribution: Multifocal, 3.8 x 2.2 cm. 813c/3 Left lateral wall Pi#m: Situ: b1adi, Nos c47.9 Right lateral wall Trigone CQCF . h1asdw,trigun cL7.0 Anterior wall 5. Ureteral margins: Negative 6. Distal urethral margin: Negative 7. Soft tissue margin or serosa: Negative 1v/31 J u 8. Lymph nodes: Eight 1ymph nodes, no tumor present (0/8) 9. pTNM: pT3NOMx Effective . this Checklist utilizes the 7th edition TNm staging system' for Bladder of the American joint Committee on Cancer (Ajcc) and the. International union Against cancer (uic). xxx [], M.D Interpretation performed by the Attending Pathologist. Electronical1y Signed Out by [] M.D clinical history: The patient is a -year-old female with bladder cancer undergoing cystectomy. Page 1
+
+--- Page 2 ---
+and ileal conduit. Specimens Received: A: Right pelvic lymph nodes B: Left pelvic 1ymph" nodes. C: Bladder D: Ovaries E: Right ureter segment. Gross Description: The specimens are received in five containers each 1abeled with the patient's name and medical record number..  The first container is additionally identified as, "right pelvic lymph A.. node". Received fresh and placed in formalin are multiple soft' tissue fragments aggregating to a total of 6.5 x 3 x 1 cm. Multiple lymph node candidates are dissected From the specimen ranging in size from 0.9 cm to 5.5 cm in longest dimension. The lymph' node candidates are submitted as follows: A1: 2 possible 1ymph node candidates. A2: One lymph node, serially sectioned A3-A4: one lymph node, serially sectioned "left pelvic lymph B. The second container is additionally identified as,. node".  Received fresh and placed in formalin are multiple fibrofatty soft tissue fragments aggregating to a total of 6 x 4.5 x 1.5 cm. Multiple lymph node candidates are dissected from the specimen ranging in size from 0.9 cm to'2 cm and submitted as follows:. B1: One lymph node candidate, bisected B2: One 1ymph node, entire. B3: 2 possibie lymph node candidates, entire B4: One 1ymph node, serially sectioned C. The third container is additionally identified as, "bladder". Received fresh and place in formalin is a 167.1 g cystectomy specimen with overall measurements of 15 x 13.3 x 2.8 cm.  The right ureteral stump measures 3.5 cm in length and 0.4 cm in diameter, and the left measures 1 cm in length and 0.4 cm in diameter. Both ureters demonstrate intact patent lumens..  The serosal surface shows yellow. Tobulated fibroadipose tissue with focal cautery artifact.  The urethral margin is inked black, and the bladder is inked blue on the right side and black on the Teft side. The specimen is opened anteriorly to reveal'a 3.8 x 2.2 cm there is a 1.5 x 0.9 cm, superficia1 ulcerated lesion near the left trigone measuring 1.5 cm from the distal urethral margin. On cut section, the larger mass infiltrates into the muscularis propria to a depth of 1.1 cm and is 0.9 cm from the deep margin. The surrounding bladder mucosa is edematous, pink-tan with a uniform 1.0 cm wali thickness.' Bilateral ureteral orifices, adjacent to the trigone, are identified and probe patent.. Representative sections are submitted as follows:. c1: Distal urethral margin. c2 : Right and left ureter resection margins (right inked blue) c3: Left lateral wall tumor, at maximum depth c4-c8: Additional sections of the ulcerative tumor. c9-c10: ulcerated lesion on the right side near the trigone c11: Uninvolved bladder mucosa 51adder dome c12: uninvolved bladder mucosa anterior wa17 c13: Uninvolved bladder mucosa, right lateral wa17 D. The fourth container is additionally identified as, "ovaries". Received fresh and placed in formalin are unoriented, bilateral'adnexal structures. One adnexa consists of a 4.1 cm long and 0.9 cm diameter fimbriated fallopian tube. The serosa is pink-red and glistening. The specimen is serially sectioned Page 2
+
+--- Page 3 ---
+revealing a pinpoint 1umen and a 0.3 cm wall thickness. The attached white-tan,. grossly unremarkable ovarian parenchyma. An occasional, yellowish firm nodule is. paipable in the peritubal region. The other adnexa consist of a 3 cm long and. 0.5cm diameter fimbriated fallopian tube. The serosa is pink-red and glistening.. The specimen is serially sectioned revealing a pinpoint Tumen and a 0.3 cm wa17. thickness. The attached white-tan, cribriform ovary measures 2.5 x 2 x 1 cm and. is sectioned to reveal fibrotic ovarian parenchyma. Representative sections are submitted as follows: D1: First fallopian tube and ovary D2: Yellowish nodules near the first adnexa D3: Opposite fallopian tube and ovary E. The fifth container is additionally identified as, "right ureter segment".. Received fresh and placed in formalin is a segment of'ureter measuring 0.9 cm in. length and 0.5 cm in diameter. There is a suture designating the non-margin. site. This side is inked blue. Opposite margin is inked green. The specimen is submitted entirely with the margin embedded en face in e1 .. Page 3
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diff --git a/output/text/df632e65-e92c-4e86-b223-276cf759b702.txt b/output/text/df632e65-e92c-4e86-b223-276cf759b702.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e85946dd784e24e2aeaf1179366dc9fa9b1782aa
--- /dev/null
+++ b/output/text/df632e65-e92c-4e86-b223-276cf759b702.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+Clinical Diagnosis and History: year old with newly diagnosed right breast cancer, core biopsy proven.  Now scheduled for right total mastectouy with Stn3 and possible ALnD with immediate reconstruction TE.. Specimens Submitted: 1: Sp: Sentinel node #1. level I, right axilla 2: SP Sentinel node #2. level UUID:A4BFA94D-166F-43D4-90B5-3CS47F4026A0 1, right axilla( 3: Sentinel node #3, level right axilla 'TCGA-A0-A126-01A-PR  Redacted SP Sentinel S: SP: Rt. breast level 1, right axilla 6SP Non sentinel axilla DIAGNOSIS: 11 LYMPH NODE, SENTINEL #1, LEVEL I, RIGHT AXILLA; EXCISION: -ONE LYMPH NODE. NEGATIVE FOR TUMOR (O/). - DEEPER LEVEL RECUTS AND SPECIAL STAINS HAVE BEEN ORDERED. THE RESULTS WILL BE REPORTED IN AN ADDENDUM. 2) LYMPH NODE, SENTINEL #2. LEVEL I, RIGHT AXILLA; SXCISION: - ONE LYMPH NODE, NEGATIVE FOR TUMOR (O/1). - DEEPER LEVEL RECUTS AND SPECIAL STAINS HAVE BEEN ORDERED. THE RESULTS WILL BE REPORTED IN AN ADDENDUM. 3) LYMPH NODE, SENTINEL #3. LEVEL I, RIGHT AXILLA; EXCISION: - ONE LYMPH NODE, NEGATIVE FOR TUMOR (O/1). - DEEPER LEVEL RECUTS AND SPECIAL STAINS HAVE BEEN ORDERED. THE RESULTS WILL BE REPORTED IN AN ADDENDUM. 1 LYMPH NODE, SENTINEL #4, LEVEL I, RIGHT AXILLA; EXCISION:  ONE LYMPH NODE, NEGATIVE FOR TUMOR (O/). - DEEPER LEVEL RECUTS AND SPECIAL STAINS HAVE BEEN ORDERED. THE RESULTS WILL BE REPORTED IN AN ADDENDUM. 5 BREAST, RIGHT: SIMPLE MASTECTOMY:S - INVASIVE DUCTAL CARCINOMA, GROWING IN SOLID, TUBULAR. AND CRIBRIFORM PATTERNS. NUCLEAR GRADE II/III (MODERATE VARIATION IN SIZE AND SHAPE). MEASURING 2.S CM IN LARGSST DIMENSION GROSSLY. - THE INVASIVE CARCINOMA IS LOCATED IN THE UPPER-INNER QUADRANT. - NO INVOLVEMENT OF THE NIPPLE BY EITHER IN-SITU OR INVASIVES CARCINOMA IS IDENTIFIED. PATH REPORT Coatiaued on noxt page  11 ICs -0- 3 Carcmome, vifilhatxg ductl, Nos 85ccf3 hw 1c/2s|1 Criterla HIPAAD Case (0(2#)
+
+--- Page 2 ---
+. NO CALCIFICATIONS ARE IDENTIFIED IN EITHER THE INVASIVE Page COMPCNENT OR IN BENIGN BREAST PARENCHYMA. - NO VASCULAR INVASION IS NOTED. 2 - INVASIVE CARCINOMA IS O.S CM FROM THE NEAREST (DEEP) MARGIN. - NO SKIN INVOLVEMENT BY CARCINOMA IS IDENTIFIED. - THE NON-NEOPLASTIC BREAST TISSUE SHOWS BIOPSY SITE CHANGES, FIBROCYSTIC CHANGES, AND FIBROADENOMATOID CHANGE. - RESULTS OF SPECIAL STAINS (ER, PR, HER2-NEU) WILL 3E REPORTED AS AN ADDENDUM. 6) LYMPH NODE, NON-SENTINEL, RIGHT AXILLA: - ONE LYMPH NODE, NEGATIVE FOR TUNOR (O/1). Report Elcctroricallv e... +d Out I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL). AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Special Studies: Stain/Procedure Name Result Coament KERATIN (CAMS.2) AEL:AE3 NEGATIVE CONTROLS IMMUNO RECUT AE1:AE3 KERATIN (CAMS.2) KERATIN (CAm5.2) AE1:AE3 NEGATIVE CONTROL IMMUNO RECUTS KERATIN (CAMS.2) AE1:AE3 NEGATIVE CONTROL IMMUNO RECUT KERATIN (CAM5.2) AE1:AE3  NEGATIVE CONTROL IMMUNO RECUT ESTROGEN RECEPTOR PROGESTERONE RECEPTOR HER2-C  NEGATIVE CONTROL IMMUNO RECUT NEGATIVE CONTROL FOR HER2 Gross Descriotion: PATH Continued on next page  REPORT 11
+
+--- Page 3 ---
+Page3 of 1) Tha specimen is received fresh for frosen section diagnosis, labeled, Sentinol Node #1, Level 1. Right Axilla*. It consists of one firm. brown-tan node, measuring 0.7 x 0.4 x 0.3 cm. ? Bisected and encirely frozen. Sumnary of Sections: FSC - frozen section control 2 labeled, -Sentinel Node #2. Level 1, Right Axilla'. It consists of one firm, brown-tan node, measuring 0.2 x 0.1 x 0.1 cm. Bisected and entirely submitted. Summary of Sections: FSC - frozen section 3) The specimen is received fresh for frozen section diagnosis, iabeled,"Sentinel Node #3, Level 1. Right Axilla". It consists Of one firm, brown-tan lymph rode, measuring 1.2 x 0.4 x 0.2 cm. Bisected and entirely submitted. Summary of Sections: Fsc - frozen section control labeled, -Sentinel Node #4. Level 1, Right Axilla'. It consists of one firm, brown-tan lymph noda, measuring 0.8 x 0.3 x 0.2 cm. Entirely submitted. Summary of Sections: Fsc - Erozen section control 5) The specimen is received fresh, labeled, *Right breast, Stitch marks axillary tail*. It is a product of a right modified mastectomy consisting of an ellipse of tan skin with breast tissue. The ellipse of skin measures 9.0 x 3.0 cm. tissue measures 17.0 x 15. x 7.0 cm. The breast visible scars are identified. The nipple is inverted.  No visible scars identified from No the skin surface. A scant amount of skeletal muscle is identified at the deep murgin which is inked. was sectioned to zeveal and ill-defined, indurated, gray white The breast tissue tumor measuring 2.5 x 1.5 x 2.0 cm and it is situated in the upper inner quadrant 1.0 cm from the deep surgicai margin, 1.5 c PATH * Continued on next page * REPORT 11
+
+--- Page 4 ---
+-.... Page i of 5 tha upper outer quadrant is a smaller tumor nodule which measures 4 1.0 cm in greatest dimension (satoilite nodules vs tumor extension).  Spreading from the mass toward the outer aspecs. is a diffuse area of fibrous tissue which is thickened and multinodular.  The fibrous tissue constitutes approximately 45t Of the breast tissue. The rest of the breast tissuo is fatty and. unremarkable. No Iymph nodes were identified at the axillary tail site. The tumor was taken for tps. of the spocimen are submitted. Representative sections Summary of Sections: N - nipple . tumor TN  separate tunor nodule LIQ - lower inner quadrant 0OQ upper outer quadrant LOQ lower outer quadrant AXT axillary tail site 6 Tho specimen is reccived in formalin, labeled,"Non-Sentincl Node Right". It consists of an irregularly-shaped portion of. Soft tissue, which measures 1.0 x 0.6 x 0.5 cm. bisected and submitted entirely.. The specimen is Summary of Sections: L - lymph node Suumary of Sections: Part Sect. Sita Blocks Pieces fsc All 1 1 2 2 Fsc H N322 12221222 m in FSC Fsc AXT LIQ LOQ N N m N T m H N TN UOQ 3 Intraoperative Consultation: Note: The diagnoses givon in this section pertain only to the tissue sample axamined at the time of the. intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS: BENIGN. PERMANENT DIAGNOSIS: SAME. 2) FROZEN SECTION DIAGNCSIS: BENIGN. PERMANENT DIAGNOSIS: PATH REPORT ontinued on next page 11
+
+--- Page 5 ---
+Page 5 of 5 3) FROZEN SECTION DIAGNOSIS: BENIGN. PERMANENT DIAGNOSIS: SAME. 4) FROZEN SECTION DIAGNOSIS: BENIgN. PERMANENT DIAGNOSIS: SAME. ADDENDUM: ** SIGNED OUT ADDENDUM REPORT SITE: SENTINEL LYMPH NODES RIGHT AXILLA PART # 1,2.3, AND 4. ADDITIONAL HE STAINED SECTIONS AND IMNUNOHISTOCHEMICAL STAINS FOR CYTOKERATINS (AEI:AE3 AND CAM S.2) SHOW NO EVIDENCE OF METASTATIC TUMOR.  Report Electronically Signed Out ADDENDUM: ** SIGNED OUT ADDENDUM REPORT SITE: BREAST. RIGHT, SIMPLE MASTECTOMY PART #5. ER-ICA: POSITIVE PR-ICA: POSITIVE HER2/NEU (HERCEPTEST) : NEGATIVE (STAINING INTENSITY OF 1+) Report Electronically Signed Out PATH +* Erd of Report. REPORT 11
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diff --git a/output/text/df7cf23d-6c3d-43bf-82e8-e75f8e42a3ca.txt b/output/text/df7cf23d-6c3d-43bf-82e8-e75f8e42a3ca.txt
new file mode 100644
index 0000000000000000000000000000000000000000..afd21daf73d6b4637d5de0cbafd43c3916e8d229
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+
+--- Page 1 ---
+ICD o-3 Caronoina, hepstecllylor uas 81703 Sut duis CqQ.D A s/J1|13 Surgical Pathology Requested By: SLIDE DISPOSITION: DIAGNOSIS: A. Lymph node, omental, biopsy: Unremarkable fibroadipose tissue. B. Liver, right lobe segment 6, wedge resection: Well-differentiated hepatocellular carcinoma forming a solitary 6.5 x 5.0 x 3.0 cm mass. Vascular invasion is not identified. The surgical resection margins are free by 0.6 cm. The background liver does not show cirrhosis.. With available surgical material, [AJcc pTl] (7th edition, 20i0). This final pathology report is based on the gross/macroscopic examination and frozen section histologic evaluation of the specimen(s).  Hematoxylin and Eosin (H&e) permanent sections are reviewed to confirm these findings. Any substantive changes identified on permanent section review will be reflected in a revised report. Interpreted by: Report electronically signed by Transcribed by: GROSS DESCRIPTION: A. Received fresh labeled "omental lymph node" is a 0.7 x 0.3 x 0.3 cm fibrofatty lymph node. All submitted. Grossed by B. Received fresh labeled "liver right lobe portion segment 6" is a 152.4 gram, 10.5 x 7.0 x 3.0 cm liver wedge specimen. A single 6.5 x 5.0 x 3.0 cm red-tan heterogenous mass is present 0.6 cm from the surgical margin. Margin is submitted perpendicularly. Representative sections are submitted. Grossed by BLOCK SUMMARY: Part A: Omental lymph node 1 Omentum LN 1 (Al) UUID: 2FCC867C-91AD-40B3-8046-FFB84BDD2EA7 Redacted Part B: Liver right lobe portion segment 6 1 Tumor 1 2 Tumor 1 3 Tumor 2 4 Tumor 2 5 Normal liver 6 Normal liver 1/251 20Z4
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diff --git a/output/text/df986c6a-b9f3-4b46-9c60-feb93ff29b6e.txt b/output/text/df986c6a-b9f3-4b46-9c60-feb93ff29b6e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ed5f037e016b84bb02940ea1a0f9a2743535516b
--- /dev/null
+++ b/output/text/df986c6a-b9f3-4b46-9c60-feb93ff29b6e.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+Informed Consent I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at Our institution.. Clinical Information Date of Birth (mm/dd/yyyy) Height Marital Status Race Temperature Blood Pressure Heart Rate HISTORY OEPRESENTILLNESS E Chief Complaints: Ahdomindl puin 1 Jeve j` hleekRtarnySto Symptoms: WeighfLosg Clinical Findings: Performance Scale (Karnofsky Score):  80-90 Symptomatic but Fully Ambulatory 60-70 Symptomatic, in bed less than 50% of day  100 Asymptomatic  20-30 Bed Ridden  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden CURRENT MEDICATIONST Drug Dose Route Frequency Date (mm/dd/yyyy) To To To To To
+
+--- Page 2 ---
+PASTMEDICALHISTORYOS Diagnosis/Disease/Disorder/Injury Diagnosis Date Treatment Status SOCALHISTORYOC Occupation: Environmental Hazards:. Smoking History. Current Status Type Packs/day Duration When Quit yES D/NO (yrs) (yr) Alcohol Consumptiond Current Status TYPE Drinks/day Duration When Quit YES q/NO (yrs) (yr) Drug Use Current Status Type Frequency Duration When Quit  YES NO (yrs) y FAMILYMEDICALHISTORYP Relative Diagnosis Age of Diagnosis LABDATA Test Result Date Test Result Date CEA  Negative  Positive: CA 15-3 Hep B  Negative  Positive: Negative  Positive: CA 19-9  Negative  Positive: Hep C  Negative  Positive: PSA  Negative  Positive: AFP  Negative  Positive: Other: Other:  Negative  Positive:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+SDIAGNOSTICSTUDIESAES Study Results Date Ultrasound X-Ray CT Endoscopy MRI Biopsy SCLINICALDIAGNOSISE Preoperative Clinical Diagnosis Location of Suspected Involved Lymph Nodes Location of Suspected Distant Metastasis Clinical Staging Date of Diagnosis Tz No mO Stage: Treatment Information NSNEMSURGICALTREATMENTE Procedure Roonn A Omdis olos. Primary Tumor Organ Detailed Location Size Asonclits celn.. xcm Mosdins Extension of Tumor. Lymph Nodes Description Location of Lymph Nodes # of Lymph Nodes Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Organ Detailed Location Size Surgical Staging. T3 NOmO Stage: Frequency Date (mm/dd/yyyy) Drug/Treatment Dose Route To 1 / / To ! / / / To 1 / / To / / To / 3
+
+--- Page 4 ---
+Pathology Form. Specimen Information Frozen Paraffin Block Blood/Serum/Plasma Slide Diseased Normal Diseased Normal Diseased Normal Diseased  Normal Z 2 2 Time to LN2 Time to Formalin Time to LN2 min 3 min min Primary Tumor Organ Size Extension of Tumor. Distance to NAT Aecordic calon Jsuwe. F x6xAcm 6 cm Lymph Nodes Location # Examined # Metastasized Distant Metastasis Organ Detailed Location Size Pathological Staging pT 3 No M  Stage: Notes: 4
+
+--- Page 5 ---
+Microscopic Description HistologicalPattern  Cell Distribution + Structural Pattern Diffuse  Streaming  Mosaic Storiform  Necrosis Fibrosis Lymphocytic Infiltration  Palisading  Vascular Invasion  Cystic Degeneration Clusterized  Bleeding  Alveolar Formation  Myxoid Change  Indian File  Psammoma/Calcification Squamous Adenomatous + Sarcomatous + Lymphomatous  Squamoid Cell Glandular cell X Round Cell  Large Cell Spindle Cell Cell Stratification  Fibroblast Small Cell  Keratin Secretion Osteoblast  RS Cell/RS Like  Desmosome Intracyt. Vacuole Lipoblast Inflam. Cell  Pearl Gland formation X Myoblast  Plasma Cell Cellular Differentiation: Well Moderate  Poor Nuclear Atypia: 0 1 11 III Aniso Nucleosis Hyperchromatism X  Nucleolar Prominent x Multinucleated Giant Cell y Mitotic Activity x Nuclear Grade: Marker Result Value Date ER  Negative  Positive PR  Negative  Positive Her-2/neu  Negative  Positive B-Cell Marker  Negative   Positive T-Cell Marker  Negative  Positive Other:  Negative  Positive Other:  Negative  Positive Final Pathology Report Histological Diagnosis:Silens ctc/eno cccino in2 Grade:71 Comments: 5
+
+--- Page 6 ---
+COnsOlIdated DiagnostIc patholOgy form* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION Diffuse STRUCTURAL PATTERN A Streaming Mosaic  Storiform Necrosis Fibrosis Lymphocytic Infiltration Vascular Invasion Palisading Cystic Degeneration Clusterized Alveolar Formation Bleeding Myxoid Change Indian File Psammoma/Calcification 2. Cellular features: Squamous + Adenomatous Sarcomatous Squamoid Cell + -Lymphomatous Glandular cell Round Cell Large Cell Spindle Cell Cell Stratification X Fibroblast Small Cell Keratin Secretion Osteoblast  RS CeIl/RS Like  Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell Pear!  Gland formation J Myoblast Plasma Cell Otherwise Specified: D2 707 Dsr% Ds 90 DA y0 2. Cellular Differentiation: Well Moderately Poor 3. Nuclear Atypia: Nuclear Appearance Aniso Nucleosis Hyperchromatism X Nucleolar Prominent  Multinucleated Giant Cell Mitotic Activity Nuclear Grade Mxeo/ Le`rue
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diff --git a/output/text/dfc1627a-b442-4ab7-befd-f3066d5df929.txt b/output/text/dfc1627a-b442-4ab7-befd-f3066d5df929.txt
new file mode 100644
index 0000000000000000000000000000000000000000..375690136dba1c4245ca0e6fd5f5f07538409fa8
--- /dev/null
+++ b/output/text/dfc1627a-b442-4ab7-befd-f3066d5df929.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis (diagnoses): Resected colon sample with a moderately differentiated adenocarcinoma of the colorectal type, measuring a max of 5.5 cm in diameter, with infiltration of the tunica muscularis propria up to the border of the pericolic fatty tissue. The tumor stage is: pT2, pN0 (0/27) pMX; G2, L0, V0, R0
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diff --git a/output/text/dfed0c0a-a555-4d1b-8e8a-d28dfefdfb59.txt b/output/text/dfed0c0a-a555-4d1b-8e8a-d28dfefdfb59.txt
new file mode 100644
index 0000000000000000000000000000000000000000..930b5dbff48384752ec4a957cbfef8f090f9ad31
--- /dev/null
+++ b/output/text/dfed0c0a-a555-4d1b-8e8a-d28dfefdfb59.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:0E27F140-3D60-4027-A370-68127564DE38 TCGA-AN-A0AR-01A-PR Redacted TSS Patient ID.  Case #: DOB: Sex: Female Ethnicity (Race). Cancer Sample Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma Date of Procurement:. Anatomic Site: Right Breast Tumor location: Primary. Tissue Specification: Tumor Specimen Matrix: Tissue Specimen Format: Frozen Container: cryomold Type of Procurement: Radical mastectomy Grade: 3 T Stage: 2 N Stage: 0 M Stage: 0 Treatment: none. Treatment Details: n/a.  Normal Sample Anatomic Site: Blood Sample Type: Normal Type of Procurement: blood draw Matrix: Blood Specimen Format: frozen Container: tube. Date of Procurement: Ics-0-3 cascinomu, n`fIt^aHry eluct,Nvs 850o/3 C50.9 Site: suist, Nos. In i0/21/1 CISQUALFEDO J Jofar/\1
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diff --git a/output/text/dff0a1b0-e538-4b0b-9416-544e9d5de0fb.txt b/output/text/dff0a1b0-e538-4b0b-9416-544e9d5de0fb.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0fd9258ca7ecbcf84c120d88e26a3ecee10a9955
--- /dev/null
+++ b/output/text/dff0a1b0-e538-4b0b-9416-544e9d5de0fb.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Other Related Data: Billing Type: Financial Number: Clinical Diagnosis & History Left renal mass. Specimens Submitted: 1:SP:Left upper poleleft kidney tum 2SPLeft mid pole kidney region 3:SP:Left posterolateral mid pole kidney 4SP:Anterior lower pole left kidne 5:SP:Lateral aspect lower pole left kidney DIAGNOSIS: 1) KIDNEY,LEE,LEFT UPPER POLE;PARTIAL NEPHRECTOMY: -RENAL CELL CARCINOMA, PAPILLARY TYPE, NUCLEAR GRADE III/IV,THE PATTERN OF GROWTH IS PAPILLARY.THE TUMOR IS CONFINED WIHIN THE RENAL CAPSULE.THE TUMOR GREATEST DIAMETER IS 4.O CM. ALL SURGICAL MARGINS ARE FREE OF TUMOR. THE NON-NEOPLASTIC KIDNEY IS UNREMARKABLE. THE ADRENAL GLAND IS NOT SUBMITTED/NOT IDENTIFIED. 2) KIDNEY,LEFS MID-POLE REGIONRESECTION: RENAL PARENCHYMA WITH NO EVIDENCE OF MALIGNANCY. 3) KIDNEY,LEF POSTEROLATERAL MID-POLE;RESECTION: FIBROVASCULAR TISSUE WITH NO EVIDENCE OF MALIGNANCY. 4) KIDNEY,LEFTANTERIOR LOWER POLE;RESECTION: -FIBROADIPOSE TISSUE WITH NO EVIDENCE OF MALIGNANCY. 5) KIDNEY,LEF,LATERAL ASPECT OF LOWER POLERESECTION: -RENAL PARENCHYMA WITH NO EVIDENCE OF MALIGNANCY. IATTEST THAT THE ABOVE DIAGNOSIS IS BASEDUPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL),AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT Gross Description: Page 1 of3
+
+--- Page 2 ---
+1) The specimen is received fresh for frozen section, labeled as "Left upper pole left kidney tumor (stitch marks deep margin). It consists of a partial nephrectomy specimen with attached fat. The portion of the kidney measures 6.5 x5.5 x3.5 cm. The surgical margin s marked with a stitch. The attached fat measures 13 x 6 x 1 cm.The fat overlying the bulging tumor and the surgical margins are inked.  The specimen is serially sectioned reveal_ng a fairly well circumscribed yellow friable tumor measuring 4 x3.5 x3.5 cm. The tumor does not appears to invade the renal capsule and it does not go into the perirenal fat.It is at least 0.9 cm away from the surgical margin of resection. The rest of the kidney parenchyma is tan-brown and unremarkable. Summary of Sections: TC-tumor tocapsule TS - tumor to surgical margin K-kidney F-perinephric fat FSC-frozen section control 2 The specimen is received fresh for frozen section,labeled as "Left mid pole k dney region r/o tumor)"It consists of two fragments of tan-brown soft tissue measuring 1.5 x 1 cm and 0.8 x 0.7cm. Entirely submitted in one block. Summary of sections: FSC- frozen section control 3) The specimen is received fresh for frozen section, labeled as "Left posterior _ateral mid pole kidney". It consists of fragments of red-tan soft tissue measuring 2 x 2 x 1 cm.in aggregate. Entirely submitted in one block for frozen section. Summary of sections: FSC-frozen section control 4) The specimen is received tresh tor trozen section, labeled as "Anterior lower pole left kidney" It consists of one fragment of tan soft tissue measuring 0.4 x 0.3 cm. Entirely submitted in one cassette. Summary of sections: FSC- frozen section control 5) The specimen is received fresh for frozen section, labeled as Page2of3
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diff --git a/output/text/e008b428-0730-4d76-a8c5-ae492eba36ee.txt b/output/text/e008b428-0730-4d76-a8c5-ae492eba36ee.txt
new file mode 100644
index 0000000000000000000000000000000000000000..258d13ad954f26bbe0acd8348d35e1a701f4e7bd
--- /dev/null
+++ b/output/text/e008b428-0730-4d76-a8c5-ae492eba36ee.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:F70E4C81-2FD6-4AA2-9AB3-3896914CF404 TCGA-Y8-A8RZ-01A-PR Redac -ted 1QD o-3 8Q46l3 Research Gross Description male with renal mass denosarcnsme, mmusmoss 848o/3 Research Dx R KidryN6S Ste  Right renal mass, partial nephrectomy: C64.9 Papillary renal cell carcinoma type 2 (see case summary).. CASE SUMMARY FOR NEPHRECTOMY FOR RENAL CELL CARCINOMA: Procedure: Partial nephrectomy Specimen laterality: Right Tumor site: Anterior upper pole, per operative report Tumor size: 1.3 cm Extent of disease: Tumor limited to kidney. Histologic type: Papillary type 2 Sarcomatoid features: Not identified Histologic grade (Fuhrman Nuclear Grade): Not applicable to papillary subtype. Margins: Uninvoived by invasive carcinoma Lymphovascular invasion: Not identified Pathologic staging (pTNM): as follows: Primary tumor: pT1 (tumor 7 cm or less, limited to the kidney) Regional Iymph nodes: pNx, lymph nodes not sampled. Distant metastasis: Not applicable Pathologic findings in nonneoplastic kidney: Focal chronic inflammation. Other tumors and/or tumor-like lesions: Not identified AJCC Staging (7th edition) pT1 pNX pM- not applicable Right colon, partial colectomy: Mucinous Adenocarcinoma (see case summary). See comment 1. CASE SUMMARY FOR COLON AND RECTUM: Resection, Including Transanal Disk Excision of Rectal Neoplasms Tumor site: Transverse colon, per operative report Tumor size: Unknown size of the primary tumor (previously partially resected). Macroscopic tumor perforation: None detected Macroscopic intactness of mesorectum: Not applicable Histologic type: Mucinous adenocarcinoma Histologic grade: High grade Microscopic tumor extension: Tumor invades muscularis propria. Margins: Negative Proximal margin: Negative Distal margin: Negative Circumferential (radial) or mesenteric margin: Negative Distance of invasive carcinoma from closest margin: 3.5 cm from the distal margin. Treatment effect: Not applicable Lymphovascular invasion: Not identified Perineural invasion: Not identified Tumor deposits (discontinous extramural extension): Not applicable. Type of polyp in which invasive carcinoma arose: Tubulovillous adenoma with at high grade dysplasia (per previous report at outside institution) Pathologic Staging (pTNM):
+
+--- Page 2 ---
+Primary tumor (pT): pT2, tumor invades muscularis propria. Regional lymph nodes (pN): pN0, no regional Iymph node involvement Number examined: 22 Number involved: 0 Distant metastasis (pM): pM-not applicable Additional pathologic findings: Previous biopsy site with tattoo, appendix with no pathologic. abnormality AJCC Staging (7th edition): pT2pN0 pM- not applicable Research QC Tumor: 100% tumor nuclei (all Type 1); I reviewed the diagnostic slides and this tumor is a mixture of Type 1 and 2 0% necrosis 0% normal Normal: 100% benign kidney. Research Specimen Specimen Process Time Blood draw time: Plasma frozen time:. Serum frozen time Buffy coat frozen time: Cold ischemia start time: Formalin fixation start time:. Total cold ischemia time Formalin fixation stopped time Total formalin fixation time: Specimen Weight Normal 1-76 mg Tumor 1-103 mg Specimen Size Plasma x 2 Serum x 2 Buffy coat x 1 Cryovials x 2 Normal x 1 Tumor x 1 FFPE x 2 Normal x 1 Tumor x 1 Study 2
+
+--- Page 3 ---
+Patient Consent Yes
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diff --git a/output/text/e02421e9-2738-4a49-9a07-4b85b785e69e.txt b/output/text/e02421e9-2738-4a49-9a07-4b85b785e69e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9f2ad754883e864c517195d5b3bcf169acdf7531
--- /dev/null
+++ b/output/text/e02421e9-2738-4a49-9a07-4b85b785e69e.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+LARGE INTESTINE TISSUE CHECKLIST Specimen type: Colectomy Specimen size: Not specified Tumor site: Transverse colon Tumor size: 2.5 x 4 x 3 cm Tumor features: None specified Histologic type: Mucinous adenocarcinoma Histologic grade: Moderately differentiated Tumor extent: Pericolonic tissues Lymph nodes: Not specified Margins: Not specified Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None
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diff --git a/output/text/e038cab1-1e53-4906-8f44-11ad8a700e0c.txt b/output/text/e038cab1-1e53-4906-8f44-11ad8a700e0c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..82aa8e84387168cfd6389003bc975607a37f5afc
--- /dev/null
+++ b/output/text/e038cab1-1e53-4906-8f44-11ad8a700e0c.txt
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+
+--- Page 1 ---
+page 1 / 1 Department of Cancer Pathology Examination: Histopathological examination Patient: XXX PESEL: XXX Age: Gender: Material: Total organ resection - segment of the large intestine. Unit in charge: Physician in charge: Material collected on: Material received on: Expected time of examination: Clinical diagnosis: Tumour of the hepatic flexure.. Examination performed on. Macroscopic description: An 18 cm length of the large intestine with a piece of the mesentery sized 20 x 7 x 5 cm, with a 7.5 cm length of the small. intestine, and a fragment of the omentum sized 11 x 8 x I,5. A cauliflower-shaped, ulcerous tumour sized 5.5 x 4 x 2.2 cm found in the mucosa. The lesion surrounds 100% of the intestine circumference, narrowing its lumen, is located 10.5 cm from the. proximal incision line, 7 cm from the distal incision line, and 3 cm from the Bauhnin's valve. Minimum side margin 6.5 cm Microscopic description: Adenocarcinoma tubulopapillare partim mucinosum (G3). Infiltratio carcinomatosa tuncae muscularis propriae et telae adiposae pericolicae. Incision lines clear of neoplastic lesions.. Metastases carcinomatosae in Iymphonodis (No Ill/vi). Infiltratio carcinomatosa telae adiposae perinodalis. Lymphonodulitis reactiva No xVIII). Adjacent omentum fragment free of cancer.. Histopathological diagnosis: Adenocarcinoma tubulopapillare partim mucinosum coli. Tubulopapillar and partially mucinous adenocarcinoma of. the colon. (G3, Dukes B, Astler-Coller B2, pT3, pNO). Compliance validated by: CONTACT YOUR DOCTOR WITH THIS REPORT!
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diff --git a/output/text/e039c1ac-a062-4251-8161-e7a943656aa4.txt b/output/text/e039c1ac-a062-4251-8161-e7a943656aa4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9d22dbf4fd5e7a40707b3743a49513c44eb536bd
--- /dev/null
+++ b/output/text/e039c1ac-a062-4251-8161-e7a943656aa4.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+SPECIMENS: A. RIGHT COLON TERMINAL ILLEUM DIAGNOSIS: RIGHT COLON AND TERMINAL ILEUM, HEMICOLECTOMY - WELL DIFFERENTIATED ADENOCARCINOMA OF THE COLON (MUCINOUS TYPE), TRANSMURALLY INVASIVE WITH EXTENSION INTO ADJACENT SOFT TISSUES.  TUBULOVILLOUS ADENOMA - FIFTEEN LYMPH NODES NEGATIVE FOR TUMOR (0/15). - APPENDIX WITH NO SIGNIFICANT PATHOLOGIC ABNORMALITIES - TERMINAL ILEUM WITH NO SIGNIFICANT PATHOLOGIC FINDINGS.E - SURGICAL MARGINS OF EXCISION ARE NEGATIVE FOR TUMOR. COLORECTAL CANCER TEMPLATE Specimen Type: Right hemicolectomy Tumor Site: Cecum Tumor Configuration: Exocytic Tumor Size: 3.2x3.2x0.6 Histologic Type: Adenocarcinoma, mucinous type - sections demonstrate infiltrating and dissecting pools of extracellular mucin, with associated tumor epithelium, consistent with a mucinous (colloid) carcinoma. Virtually all of the invasive. tumor shows mucinous morphology. Histologic Grade: Well differentiated Extent of Invasion: Tumor invades through the muscularis propria into adjacent adipose tissue and focally extend to within 1 mm. of the radial margins. Margins: Negative Venous/Lymphatic Invasion: Present. Perineural Invasion: Present  Additional Pathologic Findings: The invasive cancer appears to be arising in the. setting of a tubular villous adenoma Extent of Resection: 0 Lymph Nodes: Negative: 0/15 Implants: Absent EGFR Expression: Pathologic Stage: T3 M0 MX SPECIMEN(S): A. RIGHT COLON TERMINAL ILLEUM CLINICAL HISTORY:  None given GROSS DESCRIPTION: A. RIGHT COLON TERMINAL ILEUM: Specimen consists of a resected portion of terminal ileum and cecum measuring 15 cm. in length and circumference from varying from 4 cm. to 6 cm. An irregular polypoid lesion measuring 3.2x3.2x0.6 cm. is noted 6.5 cm. from the resected ileum margin and 7 cm. from the resected colonic margin. Appendix is identified and measures 3.2 cm. in length and 0.5 cm. in width. Representative sections are submitted as follows: Cassette A1: distal margin Cassette A2: proximal margin Cassette A3-A7: sections through the polypoid tumor mass Cassette A8: random sections of the ileum Cassette A9-A10: random sections of the cecum close to the polypoid lesion. Cassette A11: terminal ileum
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diff --git a/output/text/e0420375-a1a8-4011-99c6-d9b8fc57117d.txt b/output/text/e0420375-a1a8-4011-99c6-d9b8fc57117d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f0ec48974b428654190ee8aad03ce7cbb11bbbd9
--- /dev/null
+++ b/output/text/e0420375-a1a8-4011-99c6-d9b8fc57117d.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+page 1 / 1 Department of Cancer Pathology. copy No. 6 Date: Examination: Histopathological examination Internal invoice No. Cost of diagnostic procedure Examination No.: Patient: XXX PESEL: XXX Age: Gender: Material: 1. Partial organ resection - rectum and sigmoid colon. 2. Total organ resection -- appendix. 3. Multiple organ resection - oviducts and ovary 4. Total organ resection -- left overy. 5. Scrapings - small intestine, mesentery 6. Lesion excision - intestine Unit in charge: Physician in charge: Material collected on Material received on: Expected time of examination: Clinical diagnosis: Left oviducts and ovary Examination performed on: Macroscopic description: 1. A 18.4 cm length of the large intestine with a 20 x 4 x 3.5 cm piece of mesentery. Ulcerous tumour sized 3.6 x 3.8 x 0.9 cm found in the mucosa. The lesion surrounds 90% of the intestine circumference, is located 8.6 cm from one of the incision lines and 8.8 cm from the other. 2. Appendix of 5.9 cm in length. 3. Left ovary sized: 4.2 x 2.3 x 2.2 cm with oviduct of 10 cm in length.. 4. Fragment of the ovary sized: 4.4 x 2.7 x 1.3 cm with a cyst of 1.5 cm. 5. Many specimens of 0.8 cm diameter. 6. Two tissue rings of 2 cm diameter. Microscopic description: 1. Adenocarcinoma tubulare (G2). Infiltratio carcinomatosa telae adiposae pericolicae. Intensive inflammatory infiltration around the tumour.. Incision lines free of neoplastic lesions. Metastases carcinomatosae in Iymphonodo (NO i/xII) Histopathological Diagnosis: 1. Adenocarcinoma tubulare coli. Tubular adenocarcinoma of the colon. Metastases carcinomatosae in lymphonodo. Cancer metastases in the lymph nodes (No I/xIl). (G2, Dukes C, Astler - Coller C2, pT3, pNI). 2. Appendicitis chronica. Chronic appendicitis. 3. Corpus luteum haemorrhagicum ovarii. Haemorrhagic corpus luteum of the ovary 4. Metastasis carcinomatosa in ovario: adenocarcinoma tubulare cologenes. Cancer metastases into ovary. 5. Fragment of fibrous tissue with inflammatory infiltration.. 6. Neoplastic lesions not detected.. Compliance validated by: CONTACT YOUR DOCTOR WITH THIS REPORT
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diff --git a/output/text/e051bdce-5132-46e8-a8be-ddf5d40ca34f.txt b/output/text/e051bdce-5132-46e8-a8be-ddf5d40ca34f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..54f7fb0d59692f8bd1aa01dc881ac55a99817e82
--- /dev/null
+++ b/output/text/e051bdce-5132-46e8-a8be-ddf5d40ca34f.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:5CBF6209-2CF3-4444-B2F1-C307394C01870 TCGA-CV-A45Q-01A-PR Redacted DOB Sex: F Physician: Received Pathologist: Accession: Case type: Surgical History ** Case imported from legacy computer system. The format of this report does not match the original case. ** ** For cases prior to  the section "SpEcIMEN" may have been added. ** SUPPLEMENTAL REPORT icD-0-3 CONSULTANT: tO TIME RECD: covify c0b.9 PHOTO: NO Site: or DX cOMPLetED: h D:N SUPPLEMENTAL REPORT DIAGNOSIS : (k) Left CLaVIcLE: Bone, no tumor present. COMMENT:  The portion of mandibuiar bone from specimen A shows squamous carcinoma invading the bone, present 5.0 mm from the anterior bony resection margin. Section coDe: A21, representative section of tumor and mandible; A22-A29. anterior margin, perpendicular sections; K, representative section of clavicle. DIAGNOSIS A )LEFT RADICAL NECK DISSECTION, LEFT HEMIMANDIBULECTOMY: SQUAMOUS CARCINOMA,WELL DIFFERENTIATED, OF BUCCAL MUCOSA EXTENDING INTO SUBMANDIBULAR GLAND AND SUBMANDIBULAR SOFT TISSUE. Margins of resection free of tumor. No evidence of vascular invasion. METASTATIC SQUAMOUS CARCINOMA IN 1 OF 2O CERVICAL LYMPH NODES (O/1 SUBDIGASTRIC, O/8 MIDJUGULAR,O/1 LOWER JUGULAR, POSTERIOR CERVICAL, O/5 MIDPOSTERIOR CERVICAL, O/1 LOWER POSTERIOR CERVICAL). (SeE COMMENT) (B) MEDIAL MUCOSAL MARGIN: Squamous mucosa and soft tissue, no tumor present. (c) DISTAL MUCOSAL MARGIN: Squamous mucosa with pseudoepitheliomatous hyperplasia, no tumor present. (D) LATERAL MUCOSAL MARGIN: Squamous mucosa and soft tissue, no tumor present. (e) PROXIMAL MUCOSAL MARGIN:  Squamous mucosa with pseudoepitheliomatous hyperplasia, no tumor present. (f) PTERYGOID mUSCLE: Skeletal muscle, no tumor present. (G) MYOHYOID MUSCLE: Skeletal muscle, no tumor present. (h) BUCCAL FAT Skeletal muscle and fibroadipose tissue, no tumor present. Page 1 of 2 History Case Pathology Report History Case Pathology File under: Pathology
+
+--- Page 2 ---
+DOB: Sex: F  Physician: Received: Pathologist: Accession: Case type: Surgical History. (1) Masseter muscle: Skeletal muscle and fibroconnective tissue, no tumor present. (1) SOFT TISSUE FROM INFERIOR ALVEOLAR CANAL: Bone, no tumor present. (k) Left CLavIcle: Pending decalcification. (see comment). (L) TEETH: Multiple teeth with enamel caps, gross examination only. COMMENT are both submitted to the Bone Lab for decalcification and sectioning. An addendum report will be issued. The lymph node containing metastatic tumor is 2.0"cm in greatest dimension with a 0.1' cm focus of metastatic tumor and no extranodal extension. SPECIMEN (A)  LEFT RADICAL NECK DISSECTION, LEFT HEMIMANDIBULECTOMY: (b) MEDIAL MUCOSAL MARGIN: C DISTAL MUCOSAL MARGIN: (D) LATERAL MUCOSAL MARGIN: E PROXIMAL MUCOSAL MARGIN: PTERYGOID MUSCLE: (g) MYOHYOID MUSCLE: (h) BUCCAL FAT: MAsseter muscLe: (J) SOFT TISSUE FROM INFERIOR ALVEOLAR CANAL: (k) Left clavicle: L TEETH: SNOMED CODES T-51300,M-80703 Page 2 of 2 History Case Pathology History Case Pathology Report File under: Pathology
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diff --git a/output/text/e054b213-7a23-4fb3-9bc6-528370f02f7e.txt b/output/text/e054b213-7a23-4fb3-9bc6-528370f02f7e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..38c0bde2dd04e0aed85fa08b2f25e68ec91fbc9e
--- /dev/null
+++ b/output/text/e054b213-7a23-4fb3-9bc6-528370f02f7e.txt
@@ -0,0 +1,21 @@
+
+--- Page 1 ---
+SURGICAL PATHOLOGY REVISED REPORT Case Number : Diagnosis: FSA: Posterior floor of mouth margin, biopsy - Benign squamous mucosa and submucosa, no dysplasia or carcinoma identified FsB: Anterior floor of mouth margin, biopsy cted - Benign squamous mucosa and submucosa, no dysplasia or carcinoma identified ep Fsc: Deep tongue margin, biopsy. - Skeletal muscle, no invasive carcinoma identified FsD: Anterior deep margin, biopsy.  Skeletal muscle, no invasive carcinoma identified E: Lymph node, right neck level 1B, dissection.  No metastatic carcinoma identified (0/1)  Submandibular gland, no invasive carcinoma identified F: Lymph nodes, midline level lA, dissection - No metastatic carcinoma identified (0/4) G: Lymph node, left neck level 1B, dissection - No metastatic carcinoma identified (0/1) - Submandibular gland, no invasive carcinoma identified. H: Lymph nodes, left level 2B, dissection  No metastatic carcinoma identified (0/5) I: Lymph node, left neck level 2A, dissection - No metastatic carcinoma identified (0/9) J: Lymph nodes, left neck level 3, dissection Da Mc on - No metastatic carcinoma identified (0/7) K: Lymph nodes, left neck level 4, dissection. JtIs/2i/L3 IC - No metastatic carcinoma identified (0/8) L: Lymph nodes, right neck level 2B, dissection. -6 uos - No metastatic carcinoma identified (0/8) 3 C02.9
+
+--- Page 2 ---
+M: Tongue, right, partial glossectomy. Tumor histologic type: invasive squamous cell carcinoma Histologic grade: moderately differentiated. Primary site: right lateral tongue and floor of mouth Tumor focality: unifocal Tumor size: 3.4 x 2.5 cm diameter grossly, 0.9 cm deep microscopically (m4) Extent of invasion: Vascular: not identified Perineural: not identified Bone: n/a Ancillary studies: pending (block M7). P16, IHC studies: HR, HPV ISH status: Carcinoma in situ: not identified. Surgical margins: negative 0.4 to superior medial (M3). 0.5 cm to inferior medial (M4) 0.6 cm to  inferior lateral (M6) 1.7 cm to inferior (M4) Lymph nodes: separately submitted. Other significant findings: none. AJcc Pathologic Stage (oral cavity): pT2 pN0 pMx NoTE: This pathologic stage assessment is based on information available at the time of this report, and is subject to change pending clinical review and additional information. N: Lymph nodes, right neck level 4, dissection - No metastatic carcinoma identified (0/10) O: Lymph nodes, right neck level 2A, dissection - No metastatic carcinoma identified (0/10)
+
+--- Page 3 ---
+P: Lymph nodes, right neck level 3, dissection - No metastatic c::cinoma identified (0/10) Intraoperative Cc i:ult Diagnosis: A frozen section I.s requested by Dr. on from at FsAl: Posterior f.oor of mouth margin, biopsy - Negative for ma...gnancy. - Floater present, suspicious for previous case FsBl: Anterior flc<r of mouth margin, biopsy - Negative for ma.:.gnancy Fscl: Deep tongue r:argin, biopsy. - Negative for malignancy Fsdl: Anterior dee: margin, biopsy - Negative for malignancy Drs. at Frozen Section Patnslogist:. Clinical History: The patient is a year-old female with a clinical diagnosis of tongue cancer. Per. the patient has a stage 3. squamous cell carcinoma of 'le right lateral oral tongue. Invasive moderatel: differentiated keratinizing squamous cell carcinoma) Gross Description:. Specimen A is addit:.onally labeled "posterior floor of mouth margin" and holds e 1.4 x 0.4 x 0.3 cm red/tan soft tissue fragment. The speciren is totally submitted in block FsAl, Specimen B is additionally labeled "anterior floor of mouth margin" and holds a 1.5 x 0.5 x 0.3 cm red/tan soft tissue fragment, totally siomitted in block Fsbl, Specimen c is addit.snally labeled "deep tongue margin" and holds a 1.5 x 1.7 x ).9 cm aggregate of red/tan soft tissue fragments. The spec.nen is totally submitted in block Fscl, Specimen D is addit:<:nally labeled "anterior deep margin" and holds a 1.2 x 1.3 x (.4 cm red/tan soft tissue fragment. The
+
+--- Page 4 ---
+specimen is totally submitted in block Fsdl, Specimen E is additionally labeled "right neck level 1B" and is a 4.3 x 3.2 x 1.8 cm salivary gland with a minimal amount of attached fat. Sectioning the salivary gland reveals a lobulated glandular architecture. No discrete mass or nodule is identified. Also received within the container is a 1.4 x 1.0 x 0.4 cm lymph node candidate. Block Summary: El - Representative section from salivary gland E2 - One lymph node candidate, bisected Specimen F is labeled "midline level 1A" and is a 4.8 x 3.2 x 1.2 cm aggregate of yellow/tan fibrofatty tissue, dissected for lymph node candidates. Four lymph node candidates up to 0.6 cm in greatest dimension are identified. Block Summary: F1 - Three lymph node candidates F2 - One lymph node candidate, bisected Specimen G is labeled "left neck level 1B" and is a 5.6 x 3.8 x 1.5 cm salivary gland with a small amount of attached fibrofatty tissue. Sectioning the salivary gland reveals a lobulated glandular architecture with no discrete lesion identified. The surrounding fat is dissected for lymph node candidates. One lymph node candidate is identified in the surrounding fat and is 1.4 cm. Block Summary: G1 - Representative section from salivary gland G2 - One lymph node candidate, bisected Specimen H is labeled "left neck level 2B" and is a 2.6 x 2.5 x 1.4 cm aggregate of cauterized yellow/tan fibrofatty tissue, dissected for lymph node candidates. Six lymph node candidates up to 0.9 cm in greatest dimension are identified. Block Summary: H1 - Four lymph node candidates H2 - Two lymph node candidates Specimen I is labeled "left neck level 2A" and is a 4.8 x 3.7 x 1.0 cm aggregate of yellow/tan fibrofatty tissue, dissected for lymph node candidates. Lymph node candidates up to 1.3 cm in greatest dimension are identified.
+
+--- Page 5 ---
+Block Summary:. I1 - Six lymph node candidates. I2-I3 - Two lymph node candidates I4 - One bisected lymph node candidate Tissue remains in formalin. Specimen J is labeled "left neck level 3" and is a 5.8 x 2.7 x 1.2 cm fragment of yellow/tan fibrofatty tissue, dissected for. lymph node candidates. Lymph node candidates up to 1.4 cm in greatest dimension are identified.. Block Summary:. J1 - Three lymph node candidates J2 - Two lymph node candidates J3 - One bisected lymph node candidate J4 - One sectioned lymph node candidate Tissue remains in formalin. Specimen K is labeled "left neck level 4" and is a 4.3 x 2.9 x 1.3 cm aggregate of yellow/tan fibrofatty tissue, dissected for. lymph node candidates. Lymph node candidates up to 0.8 cm in. greatest dimension are identified.. Block Summary:. K1 - Three lymph node candidates K2 - Three lymph node candidates K3 - Two lymph node candidates Tissue remains in formalin. Specimen L is labeled "right neck level 2B" and is a 3.6 x 2.5 x 0.9 cm cauterized fragment of yellow/tan fibrofatty tissue,. dissected for lymph node candidates. Lymph nodes up to 0.4 cm in greatest dimension are identified.. Block Summary:. L1 - Three lymph node candidates L2 - Four lymph node candidates L3 - One bisected lymph node candidate Tissue remains in formalin. Specimen M is additionally labeled "right glossectomy, stitch. anterior." It holds a 5.3 cm anterior to posterior x 4.7 cm superior to inferior x 1.7 cm medial to lateral right. glossectomy. The mucosa along the superior aspect of the tongue is velvety, gray/tan. There is a 3.4 cm anterior to posterior x 2.5 cm superior to inferior ulcerated lesion along the lateral tongue/floor of mouth. This lesion has well. demarcated indurated edges and central ulceration. It comes within 0.5 cm of the inferior mucosal margin, 1.3 cm from the. anterior mucosal margin, 2.4 cm from the medial mucosal margin,
+
+--- Page 6 ---
+0.5 cm from the posterior mucosal margin. The specimen is inked as follows: superior/medial=blue, inferior/medial=black, inferior edge-red, and lateral/inferior mucosal margin=green. The specimen is sectioned from anterior towards posterior to reveal the lesion to have a verrucoid cut surface with a maximum thickness of 1.2 cm. It comes within 0.4 cm of the closest medial soft tissue margin. It is located 1.2 cm from the. posterior margin. Tumor is given to Block summary: (Inking: superior/medial-blue, inferior/medial=black, inferior edge=red, lateral/mucosal margin=green) M1-m2 - bisected section, anterior edge of tumor m3-m4 - bisected section M5-m6 - bisected section with closest medial soft tissue margin M7-m8 - bisected section, posterior edge of tumor M9 - perpendicular sections of posterior margin Oriented tissue remains in formalin. Specimen N is labeled "left neck level 4" and is a 5.6 x 3.2 x 1.2 cm aggregate of yellow/tan fibrofatty tissue, dissected for lymph node candidates. Lymph node candidates up to 0.9 cm in greatest dimension are identified. Block Summary: N1 - Five lymph node candidates N2 - Four lymph node candidates N3 - Two lymph node candidates Tissue remains in formalin. Specimen O is labeled "right neck level 2A" and is a 4.7 x 3.6 x 1.2 cm aggregate of yellow/tan fibrofatty tissue, dissected for lymph node candidates. Lymph node candidates up to 1.3 cm in greatest dimension are identified. Block Summary: O1 - Seven lymph node candidates 02 - One bisected lymph node candidate 03 - One bisected lymph node candidates 04 - One sectioned lymph node candidate Tissue remains in formalin. Specimen P is labeled "right neck level 3" and is a 3.4 x 2.8 x 1.2 cm aggregate of yellow/tan fibrofatty tissue, dissected for lymph node candidates. Lymph node candidates up to 0.5 cm in greatest dimension are identified. Block Summary: P1 - Five lymph node candidates P2 - Four lymph node candidate
+
+--- Page 7 ---
+p3 - Three lymph node candidates. Tissue remains in formalin.. Light microscopic examination performed by Dr.. The frozen section diagnoses are confirmed. hpv test results. will be reported in an addendum.. Addendum Addendum for inclusion of hpv testing results.. Addendum Comment Following case finalization, Hpv tests were received. Sections on block M7 were studied, and are negative for P16 by immunohistochemistry, and are negative for high risk Hpv by in. situ hybridization, both with appropriate external controls..
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diff --git a/output/text/e073f98a-3726-4e54-9517-41e669b54707.txt b/output/text/e073f98a-3726-4e54-9517-41e669b54707.txt
new file mode 100644
index 0000000000000000000000000000000000000000..75ab10c89829ecf78dce492ee735a09bbdb55fd2
--- /dev/null
+++ b/output/text/e073f98a-3726-4e54-9517-41e669b54707.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+Final Pathologic Diagnosis:. BASED ON THE PERFORMED GROSS AND MICROSCOPIC EXAMINATION: A. Breast, right, partial mastectomy: Infiltrating ductal carcinoma, Grade I/II. - Tubular score = 3. - Nuclear score = 3.- 1cd - 0-3 - Mitotic score = 3. - Maximum tumor dimension 6 cm. Carcmnna, mfiltraAny duct nos 850of3 - No evidence of angiolymphatic invasion.. - Focal ductal carcinoma in situ. Sire: brast,nos Cso.9. - Solid architectural pattern. - Focal cancerization of lobules. - Nonextensive pattern. - Invasive malignancy abutes deep skeletal muscle. - Surgical margins negative for malignancy.. - Stage: T3 NO MX UUID:ADDE6090-5278-42D5-8E89-E0AB630A4C060 (See Note) TCGA-GI-A2C9-01a-PR Redacted B.  Lymph nodes, right axillary, resection: No evidence of malignancy in a single lymph node. C. Lymph nodes, sentinel, dissection:. No evidence of malignancy by routine microscopic in three lymph nodes. Immunohistochemical stains pending. The examination of this case material and the preparation of this report were performed by the staff pathologist. ***Electronically Signed *** , M.D. Ph.D. Note: Infiltrating ductal carcinoma is high grade and morphologically identical to that seen in a recent previous biopsy( ). The studies for steroid receptors and HER-2/Neu overexpression were performed on the original biopsy and will not be repeated, unless otherwise requested. Gross Description: Three specimen are received fresh and labeled with the patient's name, " A. Part A labeled "right breast partial mastectomy, black-cephalad, purple-medial, blue-lateral, brown-caudad". The specimen consists of a 409 gram, red-yellow fibrofatty (14.0x 13.0 x 6.0 cm.). The sutures are present as indicated. There is a palpable protruding mass in the posterior aspect of the specimen and scant skeleta! muscle fibers. The mass protrudes 5 cm. beyond the remaining soft tissue plane. It is within 3.0 cm. from the caudal, 4.5 cm. to the lateral, 5.5 cm. from the medial and 7.0 cm. from the cephalad borders. The soft tissue and surrounding adipose tissue are inked black around the lesion. The lesion is mobile beneath the adipose tissue. On serial sectioning, there is a 6.0 x 4.0 x 3.8 cm. mass. It has fairly well circumscribed borders and a modeled grainy cut surface. The cut surface is yellow-pink, modeled, red-white and has a central area of calcification. There is a fleshy pink-red region
+
+--- Page 2 ---
+towards the cephalad portion of the tumor. It is within 0.4 cm. from the closest soft tissue margin and is slightly adherent to the portion of skeleta! muscle present. The remaining parenchyma is predominantly yellow and lobular with white-pink fibrous streaks. No additional lesions are identified. Sections are submitted as follows: "A1-2" soft tissue and tumor; "A3-7" representative sections of tumor, lateral, central, cephalad, caudal, central respectively; "A8" representative section of uninvolved parenchyma. B. Part B is designated "lymph node axillary tissue" and consists of a red-yellow lobular portion of fibrofatty tissue, 6.5 x 5.5 x 1.6 cm.  Three possible lymph nodes are identified. They are entirely submitted in "B1 and "82" ("B1" two lymph node, "B2" one lymph node). C. Part C is designated "sentinel node" and consists of an 8.0 x 2.5 x 1.3 cm. portion of yellow-red fibrofatty tissue. Three lymph node candidates are identified. They are bisected and entirely submitted in "C1-3". , mD SNOMED Code(s): B:  M850033 (Infiltrating duct carcinoma, poorly differentiated), P1100 (Excision, nos), T04000 (Breast, nos), T04010 (Female breast, nos), T04020 (Female Breast, right), M09400 (Surgical margins free of tumor) , M85002 (Intraductal carcinoma, non-infiltrating, nos), T13000 (Skeletal muscle, nos) C:  M09450 (No evidence of malignancy), P1100 (Excision, nos), T08710 (Axillary lymph node), TY8110 (Right axillary region) D:  m09450 (No evidence of malignancy) , T08000 (Lymph node, nos), Code 2 (Code 2) Procedures/Addenda: Date Ordered: Status: Signed Out Immunohistochemical By: Date Complete: Date Reported: Interpretation Immunohistochemical Stains: Immunohistochemical stains are performed for broad spectrum molecular weight cytokeratin cocktail on all lymph nodes.. Diagnosis: Lymph nodes, sentinel, excision:. No evidence of metastatic carcinoma by immunohistochemistry. Results-Comments {Not Entered}
+
+--- Page 3 ---
+Final Pathologic Diagnosis: A. Lymph node, level IIl, excision: No evidence of malignancy (3 lymph nodes) B. Breast, right, radical mastectomy: Tumor (histologic type):  Invasive ductal carcinoma. Final size of invasive tumor: 2.4 cm Scarff-Bloom-Richardson score: Tubular score: 3 Nuclear score: 3 Mitotic score: Total score:8 In-situ component: Not identified. Type: NA Percent:NA Architectural pattern: NA Nuclear grade: NA Comedo necrosis:NA Angiolymphatic invasion: Present. Skin and nipple: Tumor present in the dermis of the skin and nipple.. Dermal lymphatics: Angiolymphatic invasion is present. Microcalcifications: Not identified.. Margins (distance IT\ size of involved area):Tumor is >1 cm from all. margins. Other findings: Despite gross impression, microscopically the tumor does not invade the muscle or bone. Lymph nodes (number positive/total number): Ten lymph nodes negative for metastatic tumor (includes lymph nodes from part A). Size of largest metastasis: NA Number with extracapsular extension: NA Er, PR: Positive, see case HER2/neu:  Negative, see case pT4B, N0, MX The examination of this case material and the preparation of this report were performed by the staff pathologist. ***Electronically Signed *** , M.D. , m.d. Gross Description: Received are two fixative filled containers labeled with the patient's name and medical record number. Part A is additionally labeled "level 3 lymph nodes." The specimen consists of. three fragments of yellow-tan fibroadipose tissue ranging from 1.1 to 2.2 cm in
+
+--- Page 4 ---
+greatest dimension. Six lymph node candidates are identified, ranging from 0.3 to 1.4 cm. A1 four lymph nodes entirely submitted; two lymph nodes entirely submitted. Part B is additionally labeled "right radical mastectomy.". Specimen type: Radical mastectomy. Specimen dimensions: 21.2 x 20.5 x 4.1 cm with a 6.5 x 5.4 x 1.7 cm portion of rib and chest wall. Skin: A 20.6 x 10.2 cm ellipse of skin including the nipple is present. No scar is identified, however, there is significant puckering of the skin inferior to the nipple. Location of lesion: The location is central. Estimated size of lesion: The lesion is approximately 4.8 x 2.9 x 2.9 cm. (for final size, see Microscopic Description) Appearance of lesion: The tumor is firm and white. Distance from closest margin: The tumor appears to abut the inked deep margin. Other findings: The tumor appears to involve the included pectoralis muscle. Blocks submitted: B1  nipple; B2 tumor to inked deep margin and chest wall muscle; B3 tumor to skin and tumor greatest cross section; B4-5  additional representative tumor; B6 upper inner quadrant; B7 lower inner quadrant; B8 outer lower quadrant; B9 outer upper quadrant; B10 one axillary tail lymph node bisected, entirely submitted;. B11 three axillary tail lymph nodes entirely submitted; B12 three axillary tail lymph nodes entirely submitted; B13 chest wall bone closest to tumor after decalcification.. , m.d. Microscopic Description: The final diagnosis of each specimen incorporates the microscopic examination findings. Taken:
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diff --git a/output/text/e080558a-5aa9-46f1-8f5a-b3e7fb63b427.txt b/output/text/e080558a-5aa9-46f1-8f5a-b3e7fb63b427.txt
new file mode 100644
index 0000000000000000000000000000000000000000..616a78ccef6f249b7bbac0618531beb9f3b8b00c
--- /dev/null
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+
+--- Page 1 ---
+IeD-o3 8$0/3 BrseD NoS C5>.9 Q]13 Final Surgical Pathology Report UUID:A56585F9-9651-472B-BF53-C708A686E87D TCGA-A7-A5ZW-01A-PR  Redacted Procedure: Diagnosis Invasive ductal carcinoma, grade 2; 1.7 cm (pTlc) Ductal carcinoma in situ, cribriform type, nuclear grade 2  Resection margins negative for invasive and in situ carcinoma Unremarkable skin  Right axillary sentinel lymph node, excisional biopsy: B. Metastatic ductal carcinoma, 7 mm size with extranodal extension (snpN1a) Microscopic Description: Microscopic examination performed. A. Microscopic examination of the right breast lumpectomy specimen is summarized in the template below: Invasive Carcinoma: Histologic type: Invasive ductal carcinoma Histologic grade: 2. Overall grade: Architectural score: 2 Nuclear score: 2 Mitotic score: 2 Greatest dimension (pT): 1.7 CM (pT1c) Specimen margins: Negative for carcinoma. Closest margin is superior where tumor is 5 mm from the margin.. Vessel invasion: Not identified Calcification: Present Ductal carcinoma in situ: Histologic pattern: -Cribriform Nuclear grade: 2 Central Necrosis: Absent % Dcis of total tumor (if mixed): Approximately 10% Extensive intraductal component (present/absent): Absent Specimen margins: Negative for DcIS Calcification: Focally present Description of non-tumorous breast: Fibrosis, apocrine metaplasia, microcysts and ordinary ductal hyperplasia and adenosis. Comments: Core biopsy site changes are present.. The tumor areas of to more mitotic activity. The skin is histologically unremarkable with no extension of tumor into the skin ellipse. Prognostic markers: Performed on the prior core biopsy  Microscopic examination of the sentinel node involve the evaluation B. of 3 H&E-stained sections of each of the 3 tissue blocks. Metastatic ductal carcinoma is identified in blocks 1 and 2 and extranodal tumor is identified in block 1. The size of the tumor is 7 mm (
+
+--- Page 2 ---
+Specimen A. Right breast segments B. Right sentinel iymph node axilla (hot/blue 812). Clinical Information Breast cancer Gross Description A. Received fresh and subsequently fixed in formalin labeled "right breast segment" is a 9.3 x 8.7 x 4.3 cm yellow lobular fatty tissue fragment showing gross evidence of blue ink staining. The specimen is received in a transpect container and is partially covered with a 5.7 x 1.3 cm brown-tan wrinkled skin ellipse. The specimen has a double suture designating anterior and a single suture designating lateral. The specimen is inked as follows: The margins are inked as follows The specimen is serially The specimen shows a yellow white, sectioned from medial to lateral.. fibrofatty cut surface with a 1.7 x 1.5 x 1.5 cm ill circumscribed white tan firm lesion which comes within 0.5 cm of the superior margin, 1.5 cm of the inferior margin, within 2 cm of the skin, greater than 5 cm of the posterior margin and greater than 2.5 cm of the medial and lateral margins. The lesion is stellate and shows white rice-like pellets, grossly consistent with previous biopsy site. No additional gross lesions are identified. The specimen is received in pathology at and fixed in formalin at Representative sections of the specimen are submitted as follows: 1 - representative medial margin, 2 - representative lateral margin, 3 - representative section of the deep/ posterior margin,. - 10 - representative sections of tumor to closest margin and skin. Rs 10.. B. Received fresh and subsequently fixed in formalin labeled "right sentinel node" is a 2.4 x 1.5 x 1.0 cm blue stained pink yellow irregular rubbery tissue fragment. The specimen is trisected to show an irregular white firm central focus measuring 0.7 cm in greatest dimension. AS- 3. w 3/1s13
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diff --git a/output/text/e0838e5e-aedd-4b02-b5cd-dd22874cc0f3.txt b/output/text/e0838e5e-aedd-4b02-b5cd-dd22874cc0f3.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a74495ed78bda90f9c27ae480a9b4c66b0b7ef25
--- /dev/null
+++ b/output/text/e0838e5e-aedd-4b02-b5cd-dd22874cc0f3.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+FINAL DIAGNOSIS: PArt 1: BreaSt, Right. 3 O'ClOCk, SEgmentaL mAstectOmy -  InVASIVe DUCTAL CARciNOMA in PARt NECRoTic witH CRIBRiFORm PAtTERn AND  MICrOCAlciFiCATiOn, NOTTINghAm SCOre 6/9 (tUBuLAR fORmATiOn 2, nUCLeaR GrADe 3, mITOSeS 1) (see comment). B. THE TUmOR IS 2.0 Cm IN GREATESt DImeNSION. C.  THe TUMOR EXTeNDS TO THe iNKEo POSTERIOr SURGICAL MARGIN, AND APPROACHES THE INKED  inferior surgical margin within 0.1 cm (sLide ia). the other surgical margins are Free Of TUMOR. D THE TUMOR IS REPORTED TO BE POSITIVE FOR ER, AND NEGATIVE FOR PR, AND NO AMPLIFICATION OF HER-2/NEU E. FIBROCYSTIC CHANGES WITH FLORID DUCTAL EPITHELIAL HYPERPLASIA, ASSOCIATED  MICROCALCIFICATION AND REACTIVE FIBROSIS WITH HEMOSIDERIN PIGMENT AND FAT NECROSIS INCIDENT TO PREVIOUS BIOPSY. F.  MICROSCOPiC PERLOBULAR HEMANGIOmA, INCIDENTAL (section 1B). G.  SKIN WITH nO SIGNIFICANT HISTOPATHOLOGICAL ABNORMALITIES. Part 2: new inferior posterior deep margin, Segmental mastectomy - ' A. microscopic focus of residual buctal carcinoma with Thermal Artifacts is present (section 2A, see comment). B.INKED RESECTION MARGINS (NEW MARGINS) ARE FREE OF TUMOR.  SKELETAL MUSCLE WITH NO SIGNIFiCAnT HiSTOPATHOLOGICAL ABNORmALITy.E Part 3: sentinel Lymph node number 1, Right, biopsy . One Lymph nODe NEgatIve fOr metaStatic tumOR (ZErO/ONe) (0/1). 1cs - 0 - 3 PARt 4: SENTInEL LymPH nODE nUmBER 2, RIGhT, BIOPSy -  ONe LyMph nODe NegaTive fOr Metastatic TumOR (ZERO/One) (0/1). MICROSCOPIC: SYNOPTiC - PRimARy iNVASIVE CARCinOmA OF BREASt LATeraLity: Right Site: busst, Nos Segmental c 50.9 PROCEDURE: LOCATION: Upper inner quadrant  Maximum dimension invasive component: 2.0 cm SIZE Of TumOr: 3/13/1 h MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: No TUMOR TYPE (invaslve component) Ductal adenocarcinoma, NOs, Other Type(s): cribriform features NOTTINGHAM SCORE: Nuclear grade: 3 Tubule formation: 2 Mitotic activity score: 1 Total Nottingham score: 6 Nottingham grade (1. 2, 3): 2 ANGIOLYMPHATIC INVASION: No DERMAL LYMPHATIC INVASION: No CALCIFICATION: Yes, benign zones Yes. malignant zones SUrgICAL mArGins InVOLVED By iNVASIve COmpOnenT: No  SURG MARGINS INVOLVED BY IN SITU COMPONENT: No Paget's Disease Of nipplE: Lymph nodes positive: 0 Lymph nodes examined: METHOD(S) OF LYMPH NODE EXAMINATION: H/E stain SENTINEL NODE METASTASIS: No OnLy keratin positive Cells Are Present: No SKIN INVOLVED (ULCERATION): No NON-NEOPLASTIC BREAST TISSUE: FCD T Stage, PathologIC: pT1c N stage, pathologic: pNO M stage. pathologic: pMX ESTrOGen rECePTOrS: positive PROGESTERONE RECEPTORS: negative HER2/NEU: 2+ Ou UUID:8AC7EF1D-53E8-4668-9C45-A6A7E9DB9CCD TCGA-BH-A0HW-01A-PR Redacted
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diff --git a/output/text/e111ae7a-3a34-41a1-9689-d4b309846d7a.txt b/output/text/e111ae7a-3a34-41a1-9689-d4b309846d7a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..81302951991dddc255741f0fe13467bb9522b03f
--- /dev/null
+++ b/output/text/e111ae7a-3a34-41a1-9689-d4b309846d7a.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+ID03 UUID:7F403F75-9100-4C68-8F36-14AD78B954FD Zyjnys/ere, clyyiu leuj 3 csLNaS d&so/3 Sut Jestie Nos C62.y Q > 5(3/14 TESTE: Orchiectomy specimen of 832,1 grams that measures 10 x 9 x 6 cm. Epididymis and spermatic cord segment are identified. At gross sections a well defined solid tumour of 7 x 6,5 x 3,5 cm is identified, with hemorrhagic. and whitish areas, that represents 9o% of the testicular volume. TESTE (ORCHIECTOMY): - DIFFUSE LARGE B-CELL LINFOMA WITH A HIGH PROLIFERATIVE INDEX Histological examination shows a testicular parenchyma infiltrated by an atypical lymphoid proliferation, showing extense areas of necrosis. The tumor is constituted by layers of large atypical immunoblastic cells which. replace the practical totality of the testicle. The tumor is intensely positive for CD20, CD79a, BCL2, MUM1, with heterogeneous expression of BCL6 and is negative for CD10, CD3 and CD5. The neoplastic cells show Kappa light chain restriction. There is a very scarce intratumoral T-cell reactive lymphoid infiltration CD3 and CD5positive. The Ki67proliferation index is 100%. W 12/15
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diff --git a/output/text/e1129743-70fb-4466-9710-2b9beff4457b.txt b/output/text/e1129743-70fb-4466-9710-2b9beff4457b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..230dd1fb5b302269ef6c15b2bcfb4fe9bdfb943e
--- /dev/null
+++ b/output/text/e1129743-70fb-4466-9710-2b9beff4457b.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Sex:Female D.O.B.: UUID:A1681334-684E-41E0-B3FA-EFFE1E5A8B7F TCGA-AC-A7VC-01A-PR Redacted A Collected: Received. Reported: DIAGNOSISSOSE DIAGNOSIS: A. Left axillary Sentinel lymph node: One lymph node, no evidence of metastatic carcinoma.. IcDo-3 Confirmed by negative staining for pancytokeratin. B. Left breast mastectomy: arcenomo, mmstoeplastii NOS h areas of chondroid differentiation. 8575/3 3of3 Nuclear score: 3 of 3. Su& G nrost NoS Total score: 9 of 9. C 50.9 Grade 3. No evidence of in situ carcinoma. No evidence of angiolymphatic invasion. AtU io/s/13 Prognostic panel to follow. All surgical margins of excision are free of carcinoma. No evidence of skin or nipple involvement. TMN: T3pN0(i) Electronic Signature: NSSMCSSSEXSSCEINICALINFORMAUIO CLInIcal HIstory: Preoperative Diagnosis: Left breast mass Postoperative Diagnosis: Symptoms/Radiologic Findings: SPECIMENS: A. Left axillary sentinel lymph nodes 8. Left breast - short stitch superior MSARAMERRPRSPECIMENDATA GROSS DESCRIPTION: A.Container A is labelec Received in formalin, is a 3.0 x 1.3 x 0.8 cm slightly blue-dyed tan lymph node. The specimen is sectloned and submitted in cassettes A1-A2 labeled 8. Container B is labeled :eft breast. Received in formalin, is a 1,044 gram, 23.0 x t7.5 x 5.0 cm left simple mastectomy surfaced on one. aspect by a 20.0 x 11.2 cm ellipse ot tan-white skin with a low-central 1.2 x 1.2 x 0.3 cm nipple which exudes no discharge. Surrounding tha nipple, there is a 6.0 cm diameter patch of intense blue-dyed discoloration. The specimen is oriented with a suture at the mid aspect of one long axis Indicating. supsrior. The deep aspect of the specimen has been previously sectioned for cotlection of tissue for genomics studies. At the previous incision site, the cut surfaces give rise to a subareolar, 11.0 x 10.0 x 8.0 cm indurated, wellcircumscribed, focally cystic and mucinous tumor. The tumor is 3.5 cm from. the nearest deep margin and 3.2 cm from the nearest skin resection margin. The remaining breast parenchyma is 20% fibrous tissue. There are no. lymph nodes near the upper outer quadrant. n studies labeied and. tepresentative sections of the remaining tissue are submitted in cassettes labeled 3s followa: B1 representative nippie; B2-87 representative tumor, B8-B9 representative uninvoived upper outer quadrant; B10-B11 representative of upper inner quadrant, B12-B13 representative of fower inner quadrant: 814-B15 representative of lowel. outer quadrant.
+
+--- Page 2 ---
+nSK.There  of muitinucleated tumor giant cells. A broad panel cytokeratins was utilized. The tumor cells were negative for high molocular weight ker SQJA47 RI2
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diff --git a/output/text/e1245baa-b205-4855-bee5-d76372d4d504.txt b/output/text/e1245baa-b205-4855-bee5-d76372d4d504.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5efdc14e601dad67534ae0461c1c68afe4375d36
--- /dev/null
+++ b/output/text/e1245baa-b205-4855-bee5-d76372d4d504.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis / Diagnoses: 22-cm-long resection of the colon under inclusion of a moderately differentiated centrally ulcerated adenocarcinoma, of a maximum of 3.5 cm in diameter and of the colorectal type, with a recent onset of infiltration of the pericolic fatty tissue (pT3; G2) as well as a further poorly differentiated, centrally ulcerated colorectal adenocarcinoma,. of a maximum of 1 cm in diameter and with infiltration of the tunica submucosa (pT1;. G3). Low-grade, also focal high-grade dysplasia (synonym: high-grade intra-epithelial. neoplasia) in the remainder. Tumor-free resection margins of the colon.. A follow-up report will be made on the lymph node status. Follow-up report: A total of 39 histologically carcinoma-free lymph nodes of a maximum of 0.8 cm in diameter were determined after acetone fixation. Final tumor stage: pT3 (2) pNX (0/39) pMX; G2-3
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diff --git a/output/text/e1402a9e-8648-4509-9de5-fac645578af8.txt b/output/text/e1402a9e-8648-4509-9de5-fac645578af8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..169492ad6807fd3fa132b2115361809e2a13bea0
--- /dev/null
+++ b/output/text/e1402a9e-8648-4509-9de5-fac645578af8.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+1Cs-0-3 Carcinona, mfiltrahry duct!, nos 85oyf, c50.2 COCE. breast'Nds Cso.q IrB APprOVED l nical Case Report (For Collection of Cancerous Tissue) UUID: 24B1FA5C-7D84-4CE5-B094-2358ECE73C10 TCGA-C8-A1HO-01A-PR Redacted Informed Consent I personally informed this patient that a cyecimen(s) would be collected to be used for research purposes. I reviewed the FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Signature Date Name of Physician or Study Coordinator. Clinical Information PTAPASN GENERAEINEORMATIONA Date af Birth_(mm/dd/wwvy) Height. Marital Status Race Temperature  Single Married Weight  Widow I Blood Pressure Heart Rate Gender  Divorced 5 3 kq  Male Female FSPSASAEEHISTORYOE PRESENTILLNESS Symptoms: Lnp wos fouud ir the Arnpif. Performance Scale (Karnofsky Score):   60-70 Symptomatic, in bed less than 50% of day  100 Asymptomatic 80-90 Symptomatic but Fully Ambulatory  20-30 Bed Ridden  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden. PSOLTATCURRENTMEDICATIONS ..... Frequency Date (mm/dd/yyy) Drug Dose Route To To To To To
+
+--- Page 2 ---
+..... : PAST MEDICAL HISTORY : Diagnosis/Disease/Dlsorder/Injury  Diagnosis Date Treatment Status SOBIGYNHISTORY Date of First Menses # of Pregnancies Menopausal Status  Pre-menopausal peass sld  Peri-Menopausal Date of Last Menses # of Live Births  Post-menopausal 0 2 Birth Control:  Condom Oral Contraceptive  IUD  Hormone Replacement  Other: Therapy: AWMOSOCIAEHISTORYPAM Occupation: Environmental Hazards: Smoking History TYPE  Packs/day Duration When Quit Current Status (yrs) YES ~g0NO (yr Alcohol Consumption TYPE Drinks/day Duration When Quit Current Status  YES NO (yrs) () Drug Use TYPE  Frequency Duration When Quit Current Status (yrs) (yr)  yes AnO AAFAMILYMEDICALHISTORYMNA Diagnosis Age of Diagnosis Relative LABDATANA Test Result Date Test Result Date CEA   Negative  Positive: HIV DNegative  Positive: CA 15-3   Negative  Positive: Hep B Negative  Positive: i/  CA 19-9   Negative  Positive: Hep C Negative  Positive: PSA   Negative  Positive: AFP  Negative  Positive: Other: Other:  Negative  Positive:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+.  + ...  a. DIAGNOSTIC STUDIES: .  Study  Results Date Ultrasound X-Ray CT Endoscopy * MRI Biopsy  Baeaad. Coxco AMSCLINICALDIAGNOSISHAMT  Preoperative Clinical Diagnosis Location of Suspected Involved Lymph Nodes Location of Suspected Distant Metastasis Clinical Staging Date of Diagnosis T3 N3 MO Stage: 1C Treatment Information AMCSURGIGALTREATMENT Procedure Date of Procedure Mo dihed ! Padscal Mastets my Primary Tumor Organ Detailed Location Size BReast temer/ leet TxSx cm Extension of'Tumor Lymph Nodes Description Location of Lymph Nodes # of Lymph Nodes Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Organ Detailed Location Size Surgical Staging T3 N 3 ma Stage: NEOADJUVENTHERAPY(ChemoRadiation Immuno Hormonal orMolecular).. Dose Route Freguency Date (mm/dd/yyyy) Drug/Treatment / To / 1 To / To 1 / To / To / 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Date: Collected by: Preserved by: Date: me:_ SPECIMENTYPE#of samples provided Blood/Serum/Plasma Stide Frozen Paraffin Block Normal Diseased  Normal Diseased Normal Diseased Normal Diseased 2 2 L Time to Formalin Time to LN2 Time to LN2 min min min OPATHOLOGICAEDESCRIPTION Primary Tumor Organ Size Extension of Tumor Distance to NAT BBeaettemet (/eft x cm Lymph Nodes # Examined # Metastasized Location Distant Metastasis Detailed Location Size. Organ Pathological Staging pT 3 N 3 MO Stage: Notes: Z co78efs /RorstncKs (M) j M12)/ij N/trF ( M, cind Nz = pDs'ti'ce)
+
+--- Page 5 ---
+CONSOLIDATED DIAgNOSTIC pATHOLOgy fORm* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION Diffuse +. STRUCTURAL PATTERNS Mosaic X] Streaming Necrosis X  Storiform Lymphocytic Infiltration Fibrosis Vascular Invasion X Palisading XCystic Degeneration Clusterized Alveoia Formation X Blceding XMyxoid Change Indian File Psammoma/Calcification 2. Cellular features: Sguamows Adenomatous Squamoid Cell Sarcomatous + Lymphomatow? Glandular cel! X Spindic Cell Round Cell Lwse Cell Cell Stratification Fibrob!ast Small Cell  Keratin Secretion Osteoblast RS Cell/RS Like  Desmosome Intracyt Vacuole K Lipoblast Inflam. Cell Pear! Gland formation Myoblast Piasma Cell Otherwise Specified: Di 70% br78 D3702 Dg jO7 2.Cellular Differentiation: Well Moderately Poor Nuclear Atypia: Nuckear Appearanced Aniso Nucleosis X Hyperchromaism X Nucleolar Prominent Multinscleated Giant Celld X x Mitotic Activity Nuclear Grade Histological Diagnosis: ja$(ta tory Dsetrl CAReinrg. ts, G- 3 Date R RESEARCH USE ONCYJ. INTEGRATED REPORT OF FINDINGS BY CONTRIB
\ No newline at end of file
diff --git a/output/text/e18b4c33-e3c7-48df-a42c-3fb60e1a96fe.txt b/output/text/e18b4c33-e3c7-48df-a42c-3fb60e1a96fe.txt
new file mode 100644
index 0000000000000000000000000000000000000000..391c4633ae0b608014848998f5132962bfce346b
--- /dev/null
+++ b/output/text/e18b4c33-e3c7-48df-a42c-3fb60e1a96fe.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UUID:4CC1413A-5D03-4BE4-91E5-80B578CE7DFA TCGA-C8-A27A-01A-PR Redacted IRB APPROVEDS Multi-media systems, Inc. Form Revised Clinical Case Report jcs-0-3 (For Collection of Cancerous Tissue). Caicei ona irifiItnatmy duct, NOs 850sf3 Site: brst, n0s C5s.9 Mw 5/sfu Informed Consent I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the. consent form as a free and voluntary act. A copy of this informed consent document will be retained at. our institution. Name of Physician or Study Coordinator. Signature Date Clinical Information GENERAL INFORMATION Date of Birth (mm/dd/ww) Height Marital Statusd Race Temperatured  Single  Married Gender Weight  Divorced  Widow  Blood Pressure Heart Rate  Male XDFemale 30 T0 HISTORY OF PRESENT ILLNESS Symptoms: Clinical Findings: A tumour Way fin1 m"the Aighf h2eay} Performance Scale (Karnofsky Score):  100 Asymptomatic  80-90 Symptomatic but Fully Ambulatory  60-70 Symptomatic, in bed less than 50% of day  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden  :  20-30 Bed Ridden. CURRENT MEDICATIONS Drug Dose Route Frequency Date (mm/dd/yyy) / To / To To To To
+
+--- Page 2 ---
+PAST MEDICAL HISTORY  Diagnosis Date Treatment Status Diagnosis/Disease/Disorder/Injury OB/GYN HISTORY # of Pregnancies  Menopausal Status Date of First Menses Cz  Pre-menopausal Yeurs Ie! Date of Last Menses # of Live Births /Peri-Menopausal t.2  Post-menopausal  Hormone Replacement Birth Control:  Condom Oral Contraceptive  IUD Therapy:  Other: SOCIAL HISTORY Environmental Hazards: Occupation:  Smoking History TyPe  Packs/day Duratlon When Quit Current Status (yrs) (v YES /NO Alcohol Consumption TypE Drinks/day Duration When Quit Current Status NO (yrs) (yr)  yeS Drug Use TYPE Freguency Duration When Quit Current Status (yrs) (yr)  yes dNO FAMILY MEDICAL HISTORY  Dlagnosis Age of Dlagnosis. Relative LAB DATA Resuit Date Test Result Date Test CEA  Negative HIV  Positive:  Positive: MNegative 1 CA 15-3  Negative  Positive: HepB  Negative  Positive: CA 19-9  Negative  Positive: HepC of Negative  Positive: PSA  Positive:  Negative  Positive: AFP  Negative Other: Other:  Negative  Negative Positive:  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+DIAGNOSTIC STUDIES Study  Results Date Ultrasound X-Ray cT Endoscopy mRI Biopsy CLINICAL DIAGNOSIS Preoperative Clinical Diagnosis R. BREAST CANCER Location of Suspected Involved Lymph Nodes  Location of Suspected Distant Metastasis Clinical Staging Date of Diagnosis T2NA MO Stage: II B Treatment Information SURGICAL TREATMENT Procedure Date of Procedure Modihed Kadicas ! M asteetoony Primary Tumor Organ Detailed Location Size Beeast ImuR qdner3 x 2 x 2cm Extension of Tumor Lymph Nodes Description  Location of Lymph Nodes # of Lymph Nodes Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Organ Detailed Location Size Surgical Staging M O I 2 Stage: 1T A  NEOADJUVENT THERAPY/(Chemo, Radiation, Immuno. Hormonal, or Molecular) Drug/Treatment Dose 'Route Frequency. Date (mm/dd/yyyy) / To / To / To / 1 To 1 To / 1 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Date:, Collected by Date Time: Preserved by: SPECIMEN TYPE (# of samples provided) Biood/Serum/Plasma Slide Frozen Paraffin Biock Diseased Normal Diseased Normal Normal Diseased Normal Diseased 2 2 2 4 'Time to Formalin Time to LN2 Time to LN2 3 min min /2 min_ PATHOLOGICAL DESCRIPTION  Primary Tumor Size Extenslon of Tumor. Distance to NAT Organ 3 x2 x2 cm 5 Breost teimr C RK) Rpper crilek cm Lymph Nodes # Examined # Metastasized Location Distant Metastasis Detailed Location Size Organ Pathological Staging. pT 2 N4 mO Stage: 1B Notes: BResit`Acdeg ( Mj c+), M2 (-) 4
+
+--- Page 5 ---
+cONsOLIDaTeD DIagNOstIc pAtholOgy fOrm* Microscopic Appearance: Histological pattern: CELL DISTRIBUTION Diffuse STRUCTURAL PATTERN Mosaic Streamin Necrosis  Storiform YFibrosis Lymphocytic Infiltration Vascuiar Invasion Palisading X1 Cystic Degeneration Clusterized Alveolar Formation Bleeding Indian File Myxoid Change Psammoma/Caicification 2. Cellular Seasures: Sguamows + Adenomatous Squamoid Cell Sarcomatous Glandular cell + Lymphomatows Round Cell Large Cell Spindle Cell Cell Stratification X Fibroblast Small Celt Keratin Secretion X Osteoblast RS Ce!V/RS Like Desmosome Intracyt. Vacuole Lipoblast Inflam. Cell  Pear! Gland formatioe Myoblast Plasma Cell Otherwise Specified: 71%  D 7sZ Dz zs2 4 732 2.Cellular Differentiation: Well Modermcly Nuciear Atypia: Nuclear Appearance Aniso Nucleosis Hyperchromatism Nucleolar Prominent x Multinucleated Giant Cel! Mitotic Activity Nuckear Grade Histological Diagnosis: Iapll*a/sy >uetal Cennzors d?, (t3 Comments: Mr : ChRnrr LydjZ4dk^itY Date Direcror, Research Pathology PATHOLOGIST STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND .
\ No newline at end of file
diff --git a/output/text/e1a3f810-cef0-4267-bf76-a1c65695dbc7.txt b/output/text/e1a3f810-cef0-4267-bf76-a1c65695dbc7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..aa73c2b067acadb748ca5f609621c25e328d7a8b
--- /dev/null
+++ b/output/text/e1a3f810-cef0-4267-bf76-a1c65695dbc7.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:D9851FF2-70AC-45AD-AF18-B8A4B9F01E17 Requesting Doctor's Intormation:. TCGA-OR-A5JF-01A-PR Redacted H zcD-o-3 0 887d)3 D  Site. Ailreuo) Ghrid ,cortex C74  SPECIMEN TYPE: Adrenal A JtO 1/s0/13 T CLINICAL NOTES: L) adrenal tumour ?ACC. Cushing's syndrome.. h 0 MACROSCOPIC: 'Left adrenal tumour'. The specimen consists of an adrenal gland 57 x 40 x. L 63mm, with associated fat 100 x 40 x 12mm. The tumour has been bisected prior 0 to receipt. The total weight of the specimen including the periadrenal tat is 110g. The fat weighs approximately 30g and theretore the estimated weight of G the adrenal tumour is 80g.. Y The cut surface ot the adrenal tumour is tan and lobulated with two foci of cystic and haemorrnagic degeneration, 12mm in maximum dimension. The capsule appears otherwise intact. A wedge of tumour, 17 x 12 x 14mm has been removed prior to receipt. At the edge of the lesion there is a weil-circumscribed area that is distinct from the lesion, 22 x 17 x 12mm. The cut surface of the tumour is inked green and the capsular surface and fat inked black. On sectioning, there is an area of haemorrnage/necrosis, 17 x 13 x 12mm in maximum dimension. Normal appearing adrenal gland is seen within the fat, and focally the tumour is seen to arise from the normal adrenal. Adjacent to the larger area of haemorrhage, is a well-circumscribed zone with a haemorrhagic centre, 12mm in maximum dimension. Macroscopically the lesion appears well-circumscribed. A Representative sections in 15 blocks. Green ink covers the area where tumour N was removed prior to receipt and does not indicate a true margin.. Blocks 1, 3&4: include normal adrenal gland. A Blocks 2,3: paired T Blocks 5,6: haemorrhagic/necrotic area. Block 7: additional possible area of haemorrhage. 0 Block 8-15: additlonal sections of adrenal lesion M 1 MICROSCOPIC: The 80g adrenal tumour is an ADRENAL CORTICAL CARCINOMA. The tumour is c composed of variably pleomorphic cells. Most tumour cells have prominent A nucleoli and some multi-nucleate tumour giant cells are present. Many of the cells have voluminous eosinophilic (oncocytic cytoplasm). Using the scoring L system proposed by Weiss et al, the tumour would have a Weiss score of 4 due to high nuclear grade, atypical mitoses, predominantly eosinophilic cell type and capsular invasion. Tiny foci of necrosis are present but there is insuificient P coagulative necrosis to warrant a point under the Weiss system. No sinusoidal or venous invasion is present. The mitotic rate is 4 mitoses per 50 hpt. A Much of the tumour is confined to the adrenal, however there are unequivocal T H 0 L A
+
+--- Page 2 ---
+Requesting Doctor's Informatlon: h S T 0 P T SPECIMEN TYPE:  Adrenal h areas of microscopic invasion into the extra-adrenal fat. 0 Although the bulk of the tumour is separated from the soft tissue resection L margin by an intact capsule, pseudocapsule or soft tissue plane, microscopically carcinoma extends to involve the soft tissue margins in a few 0 areas. G The adrenal away from the carcinoma is normal. Y Immunohistochemistry ot the adrenal tumour is as follows:. IGF2: Negative. Ki-67: High proliferative index (up to 30% in areas) Calretinnin: Positive Inhibin: Positive. MelanA: Positived S-100: Negative Chromogranin: Negative A SUMMARY: Left adrenal tumour - Adrenal cortical carcinoma 80g. N A T 0 M REPORTING PATHOLOGIST: (Electronic Signature) 1 c A L D 1 wye 0 L 0 Page 2 ot 2 G Y Where'Collected' indlcates Rec: Nocdlectiondetal
\ No newline at end of file
diff --git a/output/text/e1acab91-092d-44f2-8d33-919c1ec8906c.txt b/output/text/e1acab91-092d-44f2-8d33-919c1ec8906c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3544af2babe2a0325ce261356b5be87f6418e5b8
--- /dev/null
+++ b/output/text/e1acab91-092d-44f2-8d33-919c1ec8906c.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis: This is a poorly differentiated adenocarcinoma of the colon (right colon flexure) of histopathological differentiation grade G3, with ulceration and erosions of the inner surface. of the tumor, peritumorous, chronic recurrent concomitant inflammation, accompanied by an acute inflammatory flare, with carcinomatous lymphangitis, tumor infiltration in the parietal layers of the colon as far as the extramuscular, subserous fatty connective tissue,. with tumor-free lymph nodes (0/20), moderate chronic lymphadenitis, with a diverticulum in the tumor. Tumor-free overview slices from all other resection margins identified, from. the perivascular fatty tissue of the central ligature and the omental fatty tissue.. According to the sections available, the tumor spread the colon carcinoma corresponds to a. tumor stage of pT3, pN0, MX, L1, R0. Tumor classification: ICDO-DA-M 8140/3
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diff --git a/output/text/e1e1308c-b203-497f-bd57-c26e0a357953.txt b/output/text/e1e1308c-b203-497f-bd57-c26e0a357953.txt
new file mode 100644
index 0000000000000000000000000000000000000000..79f845931ed6d8be6e4cae3fb4a0452a47f62422
--- /dev/null
+++ b/output/text/e1e1308c-b203-497f-bd57-c26e0a357953.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+IcD-o-3 UUID: 0B108361-E361-4A8B-9F5C-FC3ACB992DB9 TCGA-DD-A4NO-01A-PR Redacted 8/7d|3 Site: Liver CQQ.D M 12/24/13 REVIsED REPORT (Addendum/Procedure included) TISSUE DESCRIPTION: A1 A2 A3 A4 A5 A6 A7 A8 A9 AlO A11 B1 Tissue from liver segments II and III (aggregating 163.0 grams, 12.8. x 9.2 x 6.8 cm), tissue from liver new margin (7.8 x 1.5 x 1.5 cm). DIAGNOSIS: Liver, segments II and III and new margin, excisions: Well-differentiated hepatocellular carcinoma forming a 3.2 x 2.8 x 2.2 cm well-circumscribed but unencapsulated mass. No vascular. invasion seen. Surgical resection margins, after a single. re-excision are negative for tumor. ADDENDUM: The surrounding non-neoplastic liver shows mild, nonspecific portal inflammation with no advanced fibrosis (see comment).. ADDENDUM COMMENT: A minority of portal tracts contain a mixed inflammatory infiltrate consisting of lymphocytes with rare plasma cells and occasional. neutrophils. The latter appear to be associated with patchy. ductular proliferation. Interlobular bile ducts are intact.. A solitary portal-based granulomatous reaction is seen. The lobular parenchyma demonstrates surgical hepatitis with trace steatosis but no active steatohepatitis. There is no significant fibrosis.
\ No newline at end of file
diff --git a/output/text/e20bdbb0-641d-43fe-aa23-332c109e2a75.txt b/output/text/e20bdbb0-641d-43fe-aa23-332c109e2a75.txt
new file mode 100644
index 0000000000000000000000000000000000000000..94122dcb636b961781dd5ecc215db27ba9234f4b
--- /dev/null
+++ b/output/text/e20bdbb0-641d-43fe-aa23-332c109e2a75.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis/ diagnoses Right hemicolectomy preparation with a colon carcinoma characterized histologically as a  moderately differentiated colorectal adenocarcinoma, located 6 cm from Bauhin's valve,. and measuring a max of 2 cm in diameter. Invasive spreading of the tumor up to the level of the submucosa. Appendix with postinflammatory fibrosis of the wall and fibrous apical obliteration. Oral and aboral resection margins are tumor-free as is the greater omentum. 31 mesocolic and mesenteric lymph nodes are tumor-free with uncharacteristically. reactive lesions. Therefore the tumor stage is: pT1, pN0 (0/31) L0, V0; G2
\ No newline at end of file
diff --git a/output/text/e2144468-edce-4ac5-9c86-81df6361a95d.txt b/output/text/e2144468-edce-4ac5-9c86-81df6361a95d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e90bf787153692a4cce18a57b72f5e75844157bf
--- /dev/null
+++ b/output/text/e2144468-edce-4ac5-9c86-81df6361a95d.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SPECIMENS: A. KIDNEY LEFT  B. LYMPH NODES INTER-AORTIC CAVAL C. LYMPH NODES PERI-AORTIC SPECIMEN(S): A. KIDNEY LEFT B. LYMPH NODES INTER-AORTIC CAVAL C. LYMPH NODES PERI-AORTIC GROSS DESCRIPTION: A. KIDNEY LEFT Received fresh is a 1,098 gram nephrectomy specimen with attached perinephric fat measuring 23 x 14 x 9 cm. The cortical surface has a nodular appearance. The kidney proper is 18 x 12 x 8 cm. The parenchyma has been replaced by a papillary tan-brown mass measuring 17 x 11.8 x 8 cm. It has obliterated the renal pelvis and calyces. Areas of hemorrhage and necrosis are noted. There are clear fluid filled cysts throughout. There is a rim of normal appearing renal tissue measuring 4.5 x 3.5 x 2.1 cm. On sectioning through the mass it extends into the perinephric fat. In the hilar region there is a nodule that measures 6.3 x 4.7 x 2.7 cm. On sectioning, it appears to be an extension of a tubular structure. No adrenal gland is identified and within the perinephric fat lymph nodes are found ranging in size from 0.1 to 0.3 cm. Representative sections were taken for tissue procurement and a gross photograph was taken. Representative sections are submitted in A1 (vascular and ureteral margins), A2-A12 (tumor), A13 (renal parenchyma), and A14-A17 (multiple possible lymph nodes). B. LYMPH NODES INTER-AORTIC CAVAL Received in formalin is a piece of yellow-tan adipose tissue measuring 3.7 x 2.2 x 0.8 cm. Eight possible Iymph nodes are identified ranging in size from 0.1 to 0.8 cm. Specimen is submitted in B1 (lymph nodes), B2-B4 (one lymph node), B5 (the rest of tissue). C. LYMPH NODES PERI-AORTIC Received in formalin is a piece of yellow-tan adipose tissue measuring 3.5 x 3.2 x 1.2 cm. Three lymph nodes are identified ranging from 0.6 to 4.7 cm. in greatest dimension. Specimen is submitted in C1 (one lymph node), C2-C3 (one lymph node), C4-C5 (one lymph node), and C6 (the rest of tissue). DIAGNOSIS: A. KIDNEY, LEFT, RADICAL NEPHRECTOMY: - PAPILLARY RENAL CELL CARCINOMA, TYPE 2, INVADING PERIRENAL AND RENAL SINUS ADIPOSE TISSUE - TUMOR SIZE 17 X 11.8 X 8 CM - FUHRMAN NUCLEAR GRADE 3 - METASTATIC CARCINOMA TO SEVEN OUT OF SEVEN LYMPH PERINEPHRIC LYMPH NODES (7/7) - VASCULAR AN URETERAL MARGINS NEGATIVE FOR CARCINOMA (SEE NOTE) - SEE SYNOPTIC REPORT B. LYMPH NODES, INTER-AORTIC CAVAL, EXCISION:  - NO TUMOR SEEN IN FOUR LYMPH NODES (0/4) C. LYMPH NODES, PERI-AORTIC, EXCISION: - METASTATIC CARCINOMA TO TWO OUT OF FOUR LYMPH NODES (2/4) NOTE: There are numerous perinephric-adipose-tissue tumor depositions/lymph node involvements. The tumor is present at the inked surface in one of these foci; therefore correlation with the surgical. findings is recommended for better assessment of the final status of the Gerota#s fascial margin. SYNOPTIC REPORT - KIDNEY (PARTIAL OR RADICAL) Specimen Type: Radical nephrectomy Without adrenal gland Laterality: Left Tumor Site: Upper pole  Middle pole Lower pole Focality: Unifocal
+
+--- Page 2 ---
+Tumor Size (largest tumor if multiple): Greatest dimension: 17cm Additional dimensions: 11.8cm x 8cm Macroscopic Extent of Tumor: Tumor extension into perinephric tissues WHO CLASSIFICATION Papillary renal cell carcinoma 8260/3 Comment(s): Type 2 Histologic Grade (Fuhrman Nuclear Grade):. G3: Nuclei very irregular, approximately 20 u; nucleoli large and prominent Invasion of Vascular/Lymphatic: Present Perinephric Tissue Invasion: Absent Margins:..  Margins uninvolved by invasive carcinoma. Adrenal Gland:e Not present Regional Lymph Nodes: Positive 9 / 15. Additional Findings: None identified. Pathological Staging (pTNM): pT 3a N 2 M x CLINICAL HISTORY:  None given PRE-OPERATIVE DIAGNOSIS: Left renal mass.
\ No newline at end of file
diff --git a/output/text/e256bad3-3592-4de6-9176-46e3bd60deab.txt b/output/text/e256bad3-3592-4de6-9176-46e3bd60deab.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d78a27582fcb4d8b23fe48273bac3eb67f3263a6
--- /dev/null
+++ b/output/text/e256bad3-3592-4de6-9176-46e3bd60deab.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Patient Name: Accession #: Med. Rec. #: Date of Procedure: DOB: Date of Receipt: Gender: Date of Report: Ref. Physician: Account #: Patient Address. Billing Type: Additlonal Copy to: Ref. Source: Clinical Diagnosis & History: TCGA-BP-5187 Right renal mass. Specimens Submitted: 1: Kidney, right upper pole, partial nephrectomy DIAGNOSIS: 1. Kldney, right upper pole, partial nephrectomy: Tumor Type;  Renal cell carcinoma - Conventional (clear cell) type Fuhrman Nuclear Grade: Nuclear grade II/IV Tumor Size: Greatest diameter is 3.5 cm.L Local Invasion (for renal cortical types): Not Identified Renal Vein Invasion: Not identified Surgical Margins: Free of tumor Non-Neoplastic Kidney:  Focal chronic inflammation and vascular sclerosis Adrenal Gland: Not identified Lymph Nodes: Not identified Staging for renal cell carcinoma/oncocytoma: pT1 Tumor <= 7.0 cm In greatest dimension limited to the kidney I ATTEST THAT THE ABOVE DIAGNOSiS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Page 1 of 2
+
+--- Page 2 ---
+SURGiCAL PATHOLOGY REPORT +** Report Electronically Signed Out *** Gross Description: 1).  The specimen is received fresh labeled "Right upper pole partial nephrectomy". It consists of a 50 g, 4.5 x 4.5 x 3.5 cm portion of renal parenchyma with attached fat measuring 7.1 x 3.8 x 2.2 cm. The resected margin of the specimen is inked black. The specimen is sectioned to reveal a 3.5 x 3.2 x 2.5 cm well circumscribed hemorrhagic mass which is located 0.5 cm from the closest resected margin. The mass abuts the renal capsule but does not grossly involve it. The remainder of the renal parenchyma is brown-tan and grossly unremarkable. Representative sections are submitted. A sample of the tumor is given to TPS. Summary of sections: TM-tumor with margin TC-tumor with renal capsule RS-representative section of uninvolved kidney TN-tumor with normal kidney Summary of Sections: Part 1:  Kidney, right upper pole, partlal nephrectomy Block Sect. Site PCs 1 fsc 1 1 rs 1 tc 1 2 tm 2 Page 2 of 2 END OF REPORT
\ No newline at end of file
diff --git a/output/text/e265395b-75ff-4542-a6d0-2a6ccbb70723.txt b/output/text/e265395b-75ff-4542-a6d0-2a6ccbb70723.txt
new file mode 100644
index 0000000000000000000000000000000000000000..27d3f74eca3be254ea00c323219a98a97a238950
--- /dev/null
+++ b/output/text/e265395b-75ff-4542-a6d0-2a6ccbb70723.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:25F791D8-27D6-4DC6-8D96-505CF68A5F13 FINAL DIAGNOSIS: TCGA-BH-A42U-01A-PR Redacted Part 1:  Axilla, right, sentinel Lymph node #1 -- Colioction Dete:  One lymph node negative for metastatic tumor (0/1). Part 2:  AxIlLA, Right, Sentinel Lymph node #2 --  TWo Lymph noDes negative For metastatic tumOr (0/2). Part 3: AxIlLA, Right, non-Sentinel Lymph node -- Two Lymph noDes negatve For metastatic tumor (0/2). PArT 4: BREAST, RiGHT, TOTAL. MAStECTOMY - A. iINFILTraTING LoBuLAR CArcinomA, nOTTIngham SCORe 6/9 (tUBuLe fOrmaTiOn = 3, nUCLeAR GRADE = 2, MITOSIS = 1), 3.0 X 2.8 X 2.5 CM. S0e comment. B. NiPPLE WITH PeRIDUCTAL inFLAmMATION ANd FIBrOCySTIC ChAngeS. NO TUmOR SEeN! C TUmOr iNFILTrAteS StrIateD muSCLe FiBERS Of THe POsteriOR  MArgin, BuT The mArgin IS FREE OF TUMOR. D.  ALL SUrgIcal Lines Of ReSecTIOn Are frEE OF TuNOR. E. NO VASCULAR LYMPHATIC SPACE INVASION NOTED. Part 5: AxiLlA, Right, sentinel Lymph node #4 -- ANe Lymph nOde negative for metA8tATic tumOr (0/1) COMmenT: The diagnsosls of lobular carcinoma is confirmed with a negatve E-Cadherin immunostain.. MICROSCOPIC: SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST A. Laterality: 1. Right 2. Left B. Procedure:3 1. Segmentectomy 2. Simple mastectomy 3. Modified radical mastectomy 4. Ra-excislon C. Location: 2 1. Central subareolar 2. u0Q 4.L0Q 3. UIQ 5. LIQ 6. Not specified 3.0 cm E. Tumor Multifocal: 2 1. Yes 2. No F. Largest Diameter: 3 cm G. Aggregate Dianeter:3 cm H. Type(s) (invasive component): 7 1. Ductal, NOS 7. Lobutar 2. Tubular 3. Mucinous 8. Carcinold tike 4. Medullary 9. Metapiastic 10.Other 5. Cribriform 6. Papillary I. If obular carcinoma, specity type: 1. Classical 4. Signet ring 2. Solld 3. Alveolar 5. Trabecular 6. Plaomorphic. lobular carcinoma, histiocytic type J. Nottingham Score:  J1. Nuclear grade: J2. Tubule formation: 3 2 J3. Mitotic activity score: J4. Total Nottingham score: .6 J5. Nottingham grade (1. 2, 3): K. Lympho-Vascular Invasion: 1. Ye8 2. No L. Dermal lymphatic invasion: NA 1. Yes 2. No 3. Not applicable M. Calcification: 3 1.Yes benign zones 2. Yes mallgnant zones 3.No 1cD.0-3 carcinoma,inFi Itrating 1Obuiar,NOS 952Pj3 Sik: breast,Nos g1i2pp CI4
+
+--- Page 2 ---
+NI. uuIs: 1. Yes 2. No N2. Type of in situ component:. 1. Cribriform N/A 2. Solld 4. Micropapillary 3. Papillary 5. Apocrine 6. Comedo 7. Lobular N3. Percentage of tumor occupiod by in situ component:0%  O1. Surgical margins involved by invasive component:3 1.Yes  focal 2. Yes diffuse 3.No Q2. Distance from Margin: 1 mm O3. Which margin: 1. Superlor 2. Inferior 3. Antertor 4. Poslerior 5. Lateral 3. Medial P1. Surgical margins involved by in situ component:NA 1.Yes focal 2. Yes- diffuse 3. No P2. Distance from Margin: NA P3.Which margin: 4 1. Superor 2. Inferlor 3. Anterior 4. Posterior 5. Lateral 6. Medlal Q. Paget's disease of nipple:2. 1.Yes 2. No R. Number of positive lymph nodes: S. Total number of lymph nodes examined: T. Sentinel node metastasis: 2 1. Yes 2. No U. Only micromctastases to lymph nodes (<0.2 cm):  NA 1. Yes 2. No V. Matastasis/es to a iymph node (>0.2 cm) or more in greatest dimension: 1. Yes NA 2. No W. Lymph node metastasis/es with extracapsular extension:N/A 1. Yes 2. No X. Metastases to ipsilateral intemal mammary lymph node (if appticable):N/A 1. Yes 2. No Y. Skin invotived (ulceratlon): 1.Yes 2 2. No Z. Non-neoplastic breast tissue:. 1. ADH 4. Flbroadenoma 2. ALH 5, Papilloma 3. Radical scar 6. FCD 7.LCIS 8. Other AA. Multicentricity/muttifocality of invasive focil: 1. Yes 2. No BB. TNM stage: t 2n0m X CC. Immunohistochemistry of hormane receptors and target receptors JJ1. ER 1: Posiive JJ2. PR 1: Positive JJ3. Her2/Neu 2: Negative.
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diff --git a/output/text/e270ba56-21e7-408d-9140-942539759b8b.txt b/output/text/e270ba56-21e7-408d-9140-942539759b8b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1c0cc5cb2f289941924d529972c10c0e6a639e48
--- /dev/null
+++ b/output/text/e270ba56-21e7-408d-9140-942539759b8b.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+Clinical Diagnosis t History: y/o female with right hrsast core biopsy positive for inyasive carcinoma and left breast with atypical ductal byperplasia. For bilateral mastectomies, right sentinel node biopsy; right breast carcinoma and left atypia. Specimens Submitted: UUID:FF188295-E139-4AEE-8EE8-364536F23BE8 1: Sp: Sentinel node #1 level 1 right axilla (fs) TCGA-AO-A1KR-01A-PR 2: SP: Sentinel node #2 level 2 right axilla (fs) Redacted 3: sp: Non sentinel node, right axills 4: Sp: Non sentinel node, right axilla, evel 2 SP: Right breast 6: SP: Left breast DIAGNOSIS: 1) LYMPH NODE, SENTINEL #1 LEVEL I RIGHT AXILLA; BIOPSY: ONE BENIGN LYMPH NODE O/. - ADDITIONAL H/E STAINED SECTIONS AND DNUNOHISTOCHEMICAL STAINS FOR /cs - 0 - 3 CYTOKERATINS (AEI:AE3) SHON NO EVIDENCE OF METASTATIC TUMOR. Concinonn, infiltnating ductal, Nos 850/3 LYMPH NODE, SENTINEL #2 LEVEL II RIGHT AXILLA; BIOPSY: S.te: sreest, Nos sC50.9 ? - ONE BENIGN LYMPH NODE (O/1). - ADDITIONAL H/E STAINED SECTIONS AND IMMUNOHISTOCHEMICAL STAINS FOR CYTOKERATINS (AEI:AE3) SHON NO EVIDENCE OF METASTATIC TUMOR. 3) LYMPH NODE, NON-SENTINEL RIGHT AXILLA; BIOPSY: ONE BENIGN LYMPH NODE (O/1). 4) LYMPH NODE, NON-SENTINEL LEVEL II RIGHT AXILLA; BIOPSY: ONE BENIGN LYMPH NODE (O/1). 5) BREAST, RIGHE: TOTAL HASTECTOMY: - INVASIVE POORLY DIFFERENTIATKD DUCTAL CARCIMOIO, NOS TYPE, HISTOLOGIC GRADE IIE/IIT (SLIGHT OR NO TUBULE FORMATION). NUCLEAR GRADE III/III (MARKED VARIATION IN SIZE AND SHAPE). WITH EXTENSIVE NECROSIS, MEASURING 2.4 CM IN LARGEST DIMENSION MICROSCOPICALLY. LOBULAR CARCINOMA IN SITU (LCIS) IS ALSO IDENTIFIED, CLASSICAL TYPB (TYPE *. Continued on next page
+
+--- Page 2 ---
+Page 2 of 5 - THE INVASIVE CARCINOMA IS LOCATED IN THE OPPER INNER QUADRANT. - NO INVOLVEMENT OF THE NIPPLE BY EITHER IN SITU OR INVASIVE CARCINOMA IS IDENTIFIED, NO VASCULAR INVASION IS NOTED. - NO INVOLVEMENT OP THE SURGICAL MARGINS BY INVASIVE CARCINOMA ISS IDENTIFIED. - NO SKIN INVOLVEMENT BY CARCINOMA IS IDENTIFIED.S THE NON-NEOPLASTIC BREAST TISSUE SHOWS BIOPSY SITE CHANGES, FIBROCYSTIC AND FIBROADENOMATOID CHANGES. XICROCALCIPICATIONS FOCALLY IN BENIGN DUCTS. FIBROADENOMA NITH MYXOID STROMA MEASURING O.8 CM. -ER: O NUCLEAR STAINING. -PR:O4 NUCLEAR STAINDIG. -HER2/NEU(HSRCSPTEST) : NEGATIVE (STAINING INTENSITY OF I+). BREAST, LEFT; TOTAL MASTECTOMY: 6 - DUCTAL HYPERPLASIA USUAL TYPK WITHOUT ATYPIA.S COLUMONAR CELL CHANGES, ADENOSIS AND STROMAL FIBROSIS.S - MICROCALCIFICATIONS IN BENIGN DUCTS.S BIOPSY SITE CHANGES. - UNREMARKABLE NIPPLE AND SKIN. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL). AND THAT I KAVE REVIEWED AND APPROVEO THIS REPORT. *++ Report Electronically Signed Out *** Special Studies: Result Special Stain AB1:AE3 NEG CONT IMX RECUT AE1 :AE3 NEG CONT IMM RECUT ER-C PR-C HBR2-C NEG CONT IMM RECUT NEG-HER2 Gross Description: 1). The specimen is raceived fresh for frozen section consultation, labeled *. Continued on next page **
+
+--- Page 3 ---
+"Sentinel node number one, lavel I, right axilla' and consists of one lyuph ... Paga 3 of S node measuring l.0 cm. bisectod and entirely submitted for frozen section. Summary of sections: frozen section contxol 2). The specimen is received fresh for frozen section consultation, labeled "Sentinel node number two, level 2, right axilla' and consists of one Iymph node measuring l.4 cm, bisected and entirely submitted for frozen section. Summary of sections: FSC -- frozen section control 3). The specimen is received in formalin labeled, "Non-sentinel noda, sight axilia", and consists of one lymph node measuring 1.3 cm, which is entirely submitted. Sumaary of sections: BLN - bisected lymph node 4). The specimen is received in formalin labeled. "Non-sentinel node, level 2, right axilla", and consists of one lynph node measuring 1.0 cm, which is ontirely submitted. Summary of sections: BLN - bisected lymph node 5). The specimen is recaived fresh labeled, "right breast. stitch marks the axillary tail- and consists of a breast moasuring 24 x 23 x 3.5 cm with overlying skin ellipse measuring 16 x 8.5 cm. Situated superiorly on the Skin surface is an averted nipple maasuring 1.2 x 0.9. A suture demarcates tha axillary aspect.  The posterior surface of the breast is inked black. anterior blua and tha specimen is serially sectioned to raveal a large stellate mass measuring 2.4 x 2.2 x 1.8 cm, and iocated in the upper inner quadrant, 2 cm from deep margin, 1.0 cm from anterior skin. the axiliary aspect reveals no grossly identitiable lymph nodes. Sectioning of tunor is given to tissue bank.  254 of the Representative sections are submitted. Sunmary of sections N - nipple NB - nipple base skin - desp margin MA axillary aspect * Continued on next page *
+
+--- Page 4 ---
+UIQ upp inner quadrant LIQ lower inner quadrant UOQ upper  outer quadrant LOQ lower outer  quadrant T tumor 6). The specimen is received fresh labeled, -left breast, stitch marks the axillary tail- and consists ot a breast measuring 24 x 19 x 2.8 cm with overlying skin ellipse measuring 16 x 3.9 cm.  Situated centrally on the skin surface is an everted nipple measuring 1.5 x 1.1 cm. A suture demarcates the axillary aspect.  The posterior surface of tho breast is inked black, anterior blue and the specimen is serially sectioned to raveal a recent biopsy site, located in the lower inner quadrant. Sectioning of the axillary aspect reveals no grossly idantifiable lyaph nodes. breast consists of fibrous tissue.. 25% of Samples are given to tissue bank. Represantative sections axe submitted.. Sumary of sections: N - nipple NB - nipple base - skin D - deep margin AA - axillary aspect  uIQ - upper inner quadrant LIQ - lower inner quadrant t0Q upper outer quadrant LOQ - lower outer quadrant BxSite recent biopsy sito Summary of Sections: Part 1: SP: Santinel node #1 level 1 right axilla (fs) Block Soct. Site PCs tsc 1 Part 2: SP: Sentinel node #2 level 2 xight axilla (fs) Block Sect. Sita pCs 1 fsc 1 Part 3: Sp: Non sentinel node, right axilla. Block Sect. Site PCs 1 BLN 3  Continued on next page **
+
+--- Page 5 ---
+Page 5 of 5 Part SP: Non sentinel node, right axilla, level 2. Block Sect. Sit. PCs 1 BLN 2 Part 5: SP: Right breast Block Sect. Site PCs LIQ LOQ N SH UIQ UOQ 4 Part 6: SP: Left breast Block Sect. Sit. PCs M 1 BxSic. r D 22 LIQ LOQ UIQ 8 DOQ Intraoperative Consultation:. Note: Tha diagnoses given in this section pertain only to the tissue sauplo examined at the time of the intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS: BENIGN (0/1). PERMANENT DIAGNOSIS: SAMB 2) FROZEN SECTION DIAGNOSIS: BENIGN (0/1) PERMANENT DIAGNOSIS: SAME +* Fad of Report **
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diff --git a/output/text/e27b4c13-bf0a-4f88-a0b6-dcbaeff2e3e7.txt b/output/text/e27b4c13-bf0a-4f88-a0b6-dcbaeff2e3e7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a7a0963196de65cf0a0b2d44d82a2fdf95708953
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+jcs-0-3 Cxncionr, nfi/#aHxg oluctl, nos 85ooJ PH: SiHe 3rusot,1Iq c50.3 CQCF: St: 5Usst,Ns c50.9 Concluding diagnosis: Left breast segment at 12 o'clock with a 3 cm moderately differentiated invasive ductal. carcinoma with concomitant low-grade DCIS grade II. The resection margins lie in healthy tissue on all sides. Two of a total 16 lymph nodes with metastases (2/16). Tumor classification: pT2 (3 cm), pN1a (2/16), MX, R0; G2, L0, V0. UUID:5E615F92-6FD0-48C7-AC37-78526974BCFC Redacted
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diff --git a/output/text/e2897daa-b9a7-4792-a8dc-94844173996e.txt b/output/text/e2897daa-b9a7-4792-a8dc-94844173996e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e95646711ec6a036652f25d5f188eae02244c048
--- /dev/null
+++ b/output/text/e2897daa-b9a7-4792-a8dc-94844173996e.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+UUID: 511CB4CS-FCEE-4EC4-98A4-4DD32ECA83C3 Ics-o- 3 TCGA-A7-A0DB-01A-PR Redacted Cotcn omo,lnfi(trattNg clust,N0s 85oo/3 C50.9 Site: brsst, N0s SPECIMEN A. Sentinel node #1 right axilla, hot and blue, count of 300 B.  Sentinel node #2 palpable right axilla, not hot and not blue. C. Sentinel node #3, hot and blue, count of 70 right axilla. D. Segmental mastectomy right breast, single long lateral, double long anterior. E. Tissue medial to segmental mastectomy right breast. Stitch is new medial right margin. CLINICAL NOTES PRE-op DiAgnosIs: Right breast cancer, clinical stage 2A carcinoma. of right breast. FROZEN SECTION DIAGNOSIS A. Two lymph nodes negative for metastatic disease.. B. Single lymph node negative for metastatic disease. C. Single lymph node negative for metastatic disease.. GROSS DESCRIPTION A. Part A is received fresh for frozen section labeled "sentinel node #2 right axilla". It consists of a portion of lymph node-bearing hemorrhagic adipose tissue measuring 2 x 1.7. 0.5 cm. Within the fat two lymph nodes are present. The smaller measures 0.6 x 0.3 x 0.3 cm. On section it is dark blue and soft. The larger node measures 1.3 x 0.5 x 0.5 cm. On section it is mostly fatty with an area of dark blue discoloration. Each node is entirely submitted in one block for frozen section. B. Received fresh for frozen section labelled "sentinal node #2 palpable right axilla." It consists of a single discrete pink-tan nodule measuring 0.8 x 0.7 x 0.5 cm. On section it is homogenous soft and tan. It is bisected and all submitted in. one block for frozen section. C. Received fresh for frozen section labelled "sentinel node #3 right axilla." It consists of a single pink-blue nodule measuring 0.3 cm in diameter all submitted for frozen section 3
+
+--- Page 2 ---
+GROSS DESCRIPTION in one block. D. Received fresh for tissue procurement as "segmental mastectomy right breast." It consists of a portion of fibroadipose tissue measuring 6.2 x 5.5 x 3.8 cm. Sutures are present for orientation. The superior margin is painted orange,. inferior margin yellow, anterior margin green, lateral margin blue, medial margin red and posterior margin black. On the surface of the anteroinferior portion there is a possible piece of skin measuring. 1 x 0.6 cm. The surface of this possible skin fragment is painted red. On sectioning, the specimen, centrally, there is a biopsy cavity containing amorphous hemorrhagic debris and at least 1 rice-like foreign object. Surrounding this 1 cm cavity is an area of firm dull tan induration consistent with tumor. This tumor does not grossly approximately margins and comes apparently closest to the posterior margin. A portion of this tumor is taken for tissue procurement. The tumor measures 2.5 cm in greatest dimension. Representative sections are submitted following fixation. BLOcK summARy: D1-D2 - orange end of the specimen, D3-D4 - yellow end of the specimen, D5-d20 - biopsy cavity with adjacent margins. RS-20. E. The specimen is received unfixed labelled "tissue medial to segmental mastectomy right breast." It consists of a portion of fibroadipose tissue measuring 4.5 x 1.7 x 1 cm. A suture is present on one surface. The surface with the suture is painted orange as the opposite suface is painted black. The tissue is grossly unremarkable. As-1. BLOck suMMARy: Tissue submitted from one end to the other and submitted in cassettes E1-E5. As-5.
+
+--- Page 3 ---
+MICROSCOPIC DESCRIPTION Invasive carcinoma: Histologic type: Ductal Histologic grade: Moderately differentiated Overall grade: 2 Architectural score: 2-3 Nuclear score: 2-3 Mitotic score: 1 Greatest dimension (pT): 2.5 cm, pT2 Specimen margins: Invasive carcinoma extends to 2 mm from the anterior margin of excision. Vessel invasion: Not identified Calcification: Multifocal calcifications are identified within the invasive carcinoma. Ductal carcinoma in situ: Histologic pattern: Cribriform Nuclear grade: 2 Central necrosis: J Focally present % Dcis of total tumor (if mixed): Less than 25% Extensive intraductal component (present/absent): Present Specimen margins: Ductal carcinoma in situ is present 0.5 mm from the anterior margin of excision. Calcification: Present Description of non-tumorous breast: Fibrocystic changes with mild to florid ductal hyperplasia and microcalcifications identified associated with benign breast epithelium. Skin with central ulceration, inflammation and reactive changes. Comments: The sentinel lymph nodes are serially sectioned and stain with keratin immunohistochemistry. Within the invasive carcinoma focal perineural invasion by tumor is identified. A p63 stain is performed on several blocks to evaluate DcIs.
+
+--- Page 4 ---
+MICROSCOPIC DESCRIPTION Lymph nodes: Number of positive nodes of total: Zero, 0/4. pN: pN0 Distant metastasis (pM): pMX 14x3, 15xl, 20x4, 4x5 DIAGNOSIS A. Lymph node, sentinel node #l, right axilla, excision -- Two lymph nodes negative for metastatic carcinoma (0/2).. B. Lymph node, sentinel node #2, excision -- One lymph node negative for metastatic carcinoma (0/1). C. Lymph node, sentinel node #3, excision -- One lymph node negative for metastatic carcinoma (0/1). D. Breast, right, segmental mastectomy -- Invasive moderately. ductal adenocarcinoma and ductal carcinoma in situ (see tumor characteristics in the mastectomy template in the microscopic description). E. Breast, tissue medial to segmental mastectomy, excision Fibrocystic changes with mild to moderate ductal hyperplasia and microcalcifications identiifed associated with benign breast. epithelium. M.D. (Electronic Signature) - End of Report
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diff --git a/output/text/e29e4378-288c-447c-bd34-91436a09dcd4.txt b/output/text/e29e4378-288c-447c-bd34-91436a09dcd4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..aa9d1d36a37c7bc30cd5fdf1b7ab224bf606499a
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Tss id. TSS ID:t OC ID Date of Procurement Gross Description: Mammary gland with the tumour of 2.5 x 2.2 cm in size; fatty tissue lymph nodes are dense, hyperemic. Microscopic Description: Infiltrating duct carcinoma, G2. Ten dissected lymph nodes demonstrate metastases. Diagnosis Details: Tumor Features: Unknown, Tumor Extent: T2 tumor size more than 2cm not more than 5 cm, Venous Invasion: Absent, Margins: Absent, Treatment Effect: Comments: 1cs-0-3 Postoperative staging reads: T2N3aM0. Carcinoma infiHtratmq duct,Nos 85of3 Formatted Path Report: Sit: bvaot, nos c50.9 4/8/n BREAST TISSUE CHECKLIST Specimen type: Radical mastectomy Specimen size: Not specified Tumor site: Upper inner quadrant Tumor size: 2.2 x 0 x 2.5 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinomae Histologic grade: Moderately differentiated Tumor extent: Not specified UUID:BE186852-8596-4CDB-B5C4-AA5838C15B5F3 TCGA-E9-A1R3-01A-PR Redacted  Lymph nodes: 10/10 positive for metastasis (Axillary 10/10) Extracapsular invasion of the lymph nodes: Not specified Margins: Uninvolved Nottingham Histoiogic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified
+
+--- Page 2 ---
+TSS ID Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified. Additional pathologic findings: Not specified. Comments: None Laterality: Right, upper outer quadrant
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diff --git a/output/text/e2b58ee6-7327-4106-9c58-9f8378fbcc81.txt b/output/text/e2b58ee6-7327-4106-9c58-9f8378fbcc81.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d0f779d1258f072e01d54483805586f0965d35b1
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TCGA # Internal Sample ID Diagnosis: The material in I is a partial resection of small intestine with reactive lesions, The material in II is a preparation of the rectosigmoid colon (in clinical terms attributable to the rectum or the sigmoid colon) with a poorly differentiated carcinoma in the area of the rectosigmoid junction (G3), with infiltration of blood and lymph vessels (L1, V1) and a lymph node metastasis (pN1). Locally, the lesion was completely removed.. The distance from the mesorectal fascia was at least I cm.. The overall clinical findings and the topography should serve to determine whether this is a rectal carcinoma in the narrower sense of the term or a carcinoma of the sigmoid colon. JCD-0 -3 Casceriomu, Nos 801o/3 TCGA-AA-A02F-01A-PR 4-7085F391A418 Redacted
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diff --git a/output/text/e2da76ed-7e69-4a20-b767-1d2e6010819b.txt b/output/text/e2da76ed-7e69-4a20-b767-1d2e6010819b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..68eae5bba3867730745c9ce9c9ebca78a480f860
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+icp~ o-5 7500/3 nifiltrating ducte! nos. Carciomt, 1/371n pw FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: FMP/SSN: Specimen #: DOB/Age/Sex: F Race: wHITE Location: Taken: Received: Physician(s) : Reported: * * AMENDED* * SPECIMEN: A: RIGHT BREAST BIOPSY B: SENTINEL LYMPH NODE#1 C: SENTINEL LYMPH NODE#2 FINAL DIAGNOSIS: A. BREAST, RIGHT, EXCISION: -INFILTRATING DUCTAL CARCINOMA, POORLY DIFFERENTIATED (MODIFIED BLOOM-RICHARDSON GRADE 9: MITOSES=3, NUCLEAR PLEOMORPHISM=3, TUBULE FORMATION=3). -TUMOR SIZE 2.0 CM. -TUMOR IS LESS THAN O.1 CM FROM ANTERIOR AND MEDIAL SURGICAL MARGINS. -ASSOCIATED FINDINGS: FIBROCYSTIC CHANGES INCLUDING STROMAL SCLEROSIS AND MICROCYSTS. -MICROCALCIFICATIONS IDENTIFIED, ASSOCIATED WITH BENIGN BREAST TISSUE. -IMMUNOHISTOCHEMICAL STAINS FOR ESTROGEN AND PROGESTERONE AS FOLLOWS: ESTROGEN RECEPTOR: NEGATIVE. PROGESTERONE RECEPTOR:  POSITIVE. -HER2/NEU (FISH METHODOLOGY): NOT AMPLIFIED (1.3). B. LYMPH NODE, SENTINEL LYMPH NODE#1, BIOPSY: -ONE (1) LYMPH NODE POSITIVE FOR METASTATIC CARCINOMA ON H AND E AND IMMUNOHISTOLOGIC SECTIONS. -TUMOR SEEN IS APPROXIMATELY O.5 CM IN SIZE. C. LYMPH NODE, SENTINEL LYMPH NODE#2, BIOPSY: -ONE (1) LYMPH NODE POSITIVE FOR METASTATIC CARCINOMA ON H AND E AND IMMUNOHISTOLOGIC SECTIONS. -TUMOR SEEN LESS THAN O.1 CM IN SIZE. COMMENT : This case is amended to reflect the review of. immunohistochemical stains for estrogen and progesterone receptors and. FIsH for Her2/neu amplification.  There is no change in diagnosis. COMMENT UUID:1E8B978E-3D1B-46E8-80EE-3A11EE571CEC TCGA-A2-A0ST-01A-PR Redacted ge 1 Continued on Next Page ONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 2 ---
+FOR ORFICIAL USR ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: FINAL DIAGNOSIS (continued): Case amended by to report results of HER2 analysis by immunohistochemistry (DAko Hercep Test): HER2/NEU PROTEIN OVEREXPRESSION: NEGATIVE (SCORE: 1+). Report Electronically Signed Out ** CLINICAL DIAGNOSIS AND HISTORY: -year-old female with palpable mass on right breast with no ultrasound or mammographic correlation. GROSS DESCRIPTION: A. RIGhr BReAsT BIopsy received in formalin, labeled with the patient's name, designated "RIGHT BREAsT ExcIsIONAL BIOPsy" is a lumpectomy specimen measuring 10.2 x 7.0 x 3.0 cm in dimension. The specimen is composed largely of yellow, lobulated, glistening adipose tissue admixed with white fibrous areas. The specimen will be inked and oriented as follows: Black-deep, yellow=anterior, blue-medial, green=lateral, and red denotes superficial and inferior. The specimen is serially sectioned from superior to inferior revealing a fiarly well-defined, grey/tan nodule, 1.5 cm in greatest dimension, abutting the anterior margin in the mid portion of the specimen. Immediately adjacent to this nodule is a 1.5 cm patch of indurated fibrous tissue involving the anterior and medial margins. The remaining tissue consists of an admixture of fibrous tissue (approximately 40%) and fat (approximately 60%). The fibrous tissue is variabiy indurated, particularly in' the inferior half of the specimen. Sections of. nodule and fibrous tissue are harvested for the cbcp protocol. Matching paraffin sections are as follows: Al: Nodule. A2: Indurated fibrous tissue adjacent to A1. A3: Fibrous tissue 3.0 cm inferior to nodule. A4: Fibrous tissue 6.0 cm inferior to nodule at the inferior margin. The remainder of the specimen is serially sectioned and submitted from superior to inferior as follows: A5-A12: Representative section from each level from superior to inferior. Page 2 Continued on Next Page. FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 3 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT Or 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION (continued) : A13-A14: Next lower level. A15-A16: Next lower level. Al7-A18: Inferior most section. B. sENTINEL LyMPh NoDE#1 received in formalin, labeled with the patient's name, designated "SUPERIOR LYMPH NODE NUMBER ONE" is a 1.7 x 1.3~x 0.8 cm lymph node. A small portion of the node is harvested for the cBcp protocol. The remaining tissue is entirely submitted in cassette B1. C. SENTINEL LyMPH NODE#2 received in formalin, labeled with the patient's name, designated "SENTINEL LYMPH NODE NUMBER TWO" is a 1.2 x 0.8~x 0.5 cm tan/brown lymph node. The tissue is entirely submitted in cassette C1. Page 3 End of Report FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
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diff --git a/output/text/e2e9cab4-6242-4a65-a1f1-612199403938.txt b/output/text/e2e9cab4-6242-4a65-a1f1-612199403938.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a8481b1030eea4627089bf686ab724e0fde407f0
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Department of Pathology Page 1 of 3 REPORT Tel: UUID:78FF7875-29D1-4636-89A2-5D19ACACA019 TCGA-VD-A8KN-01A-PR Redacted Clinical Consultant & Location Sex Unit No This Copy For: IcD-0:3 SPECIMEN LEFT ENUCLEATED EYE, PROGNOSTIC ceSl miteo' 8770/3 CLINICAL DETAILS Sib: OChoroul c693 Choroidal melanoma. Tumour size: 13.7 x 15 (4.4)mm. HJ 1117/14 MACROSCOPIC DESCRIPTION A fresh, intact left globe. Dimensions: Axial 22.5mm, Horizontal 24mm, Vertical 24mm Cornea: Horizontal 11.Smm, Vertical 1lmm Optic nerve Length 3.5mm, Diameter 4mm Pupil: regular Angle: normal On trans-illumination, a large shadow approximately 13.5mm in diameter is seen extending between the optic nerve and just anterior to the equator. Plane of section: oblique Intraocular description: On opening, a solitary dome shaped choroidal pigmented mass is seen - imm of the optic disc. Tumour size LBD 15mm, Height 4.7mm MICROSCOPY Sections show a variably pigmented choroidal melanoma of mixed cell type in which the epithelioid cells amount up to 60%. Focal peripheral area of the tumour shows clear cell changes / balloon type of cells. Tumour cells express Melan-A and HSp 27 (score 2). Reported: Pathologist: Electronically Verifled:.
+
+--- Page 2 ---
+xined Department of Pathology. Page 2 of 3 , HISTOPATHOLOGY REPORT Tel:  Surname Lab No Clinical Consuttant & Locationd Forename(s)  DOB/Age Sex Unit No Request Date This Copy For: The number of mitosis is small, approximately 2/4o high power fields. The microvasculature of the melanoma is prominent, and closed loops are present in the planes of. sections. The lymphocytic infiltrate within the tumour is minimal. Scattered macrophages are present. Tumour necrosis is not seen. Bruch's membrane appears breached in the. sections examined. There is minimal tumour extension into the sclera. No tumour is seen in sections of optic nerve or vortex veins examined. Tumour cells are not seen at the resection margins. Elsewhere, the cornea shows no significant abnormality. The. anterior chamber angles are open and the anterior chamber is. shallow. The iris shows no significant abnormality but the ciliary body appears atrophic with hyalinisation of ciliary. processes. The lens shows subcapsular degenerative changes. Retina overlying the tumour is slightly atrophic.. DIAGNOSIS Left eye, enucleation: Choroidal melanoma of mixed cell type. SUMMARY SPECIMEN 2= Eye TUMOUR PRESENT Yes TUMOUR TYPE 1= Melanoma CELL TYPE 3= Mixed CT LOOPS 2= Closed loops NECROSIS NO PIGMENTATION Yes LYMPHOCYTIC INFILTRATION NO MITOTIC FREQUENCY 2/40 HPF SER1O FREQUENCY 2/40 HPF DIFFUSE MELANOMA No SPREAD 2= Intra-scleral Reported: Pathologist: Electronically Verifled:
+
+--- Page 3 ---
+orined Department of Pathology Page 3 of 3 HISTOPATHOLOGY REPORTTeI:  Surname Lab No Clinical Consuitant & Location Forename(s) DOB/Age Sex Unit No Request Date This Copy For: CLEARANCE 2= Adequate HSP-27 POSITIVITY 2= 21-70% LARGE DIAMETER 15 mm THICKNESS 4.7 mm COMMENT MOLECULAR DIAGNOSTICS In the meantime, molecular genetic analysis of tumour DNA extracted from the fresh uveal melanoma tissue was performed using the technique termed multiplex ligation-dependent probe amplification (MLpA). These investigations were performed in the The kit p027 from  which examines for gains or losses in 31 loci on chromosomes 1, 3, 6 and 8, was used. The DNA concentration was measured using . and the quality assessed using multiplex-pcR prior to the MLPA reaction. The DNA concentration was high and of good quality on assessment. The MLpA reaction was run at least twice on differing occasions, resulting in similar results. The results of the sequence analysis of the MLpA products is printed on a separate report. In summary, sequence analysis demonstrated: loss of chromosome 1p. monosomy 3, partial losses of chromosome 6 and gains in chromosome 8q. These molecular data require correlation with the clinical and morphological data for metastatic risk assessment. Reported: Pathologlst: Electronically Verifled: w 1G/l3 HIPAA Discrepa Case is (circle
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diff --git a/output/text/e2fc5df1-ee9d-404f-8e7d-18ed446eecdb.txt b/output/text/e2fc5df1-ee9d-404f-8e7d-18ed446eecdb.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8214a0e3e022a39fe177e8e041cc1695970d8d5d
--- /dev/null
+++ b/output/text/e2fc5df1-ee9d-404f-8e7d-18ed446eecdb.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis/Diagnoses: Colonic resection specimen (rectosigmoid junction) including a tubular adenoma with focal severe dysplasia and transitions to adenocarcinoma in situ (synonym: high-grade intra-epithelial neoplasia) with ulcerated, moderately to poorly differentiated adenocarcinoma with incipient infiltration of the perimuscular fat tissue (G2 to 3, pT3) (cf. preliminary biopsy findings and with tumor-free oral and aboral margins. Follow-up report: Twenty-six lymph nodes of up to O.9 cm in size in the vicinity of the tumor were dissected out from the pericolic fatty tissue after clarification with acetone. Fifteen of these exhibit metastatic infiltrates from the previously diagnosed adenocarcinoma or colon carcinoma. In conclusion or in summary, therefore, a stage of T3 pN2 (15/26) is established..
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diff --git a/output/text/e30cfbf9-5b5f-4dab-ab7d-417803a72ed4.txt b/output/text/e30cfbf9-5b5f-4dab-ab7d-417803a72ed4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fae765956cc4be89073d6b552908e1d87a1afe51
--- /dev/null
+++ b/output/text/e30cfbf9-5b5f-4dab-ab7d-417803a72ed4.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+FOR OFFICIAL USE ONLY  -PERSONAL DATA RIVACY ACT OF SURGICAL PATHOLOGY REPORT Patient: Specimen #: FMP/SSN: DOb/Age/Sex: (Age: F Race: WHITE Taken: Location: Received: Physician(s) : Reported: 1cs-0-3 Carcioma,mfiItraHvg 1obulor, Nos 8520/3 SPECIMEN: LEFT BREAST Sit. sryst, NOS C 50.9 1/24/11 FINAL DIAGNOSIS: BREAST, LEFT, MASTECTOMY:  MODERATELY DIFFERENTIATED (GRADE II/III) INFILTRATING LOBULAR CARCINOMA. * NOTTINGHAM SCORE: 6 OF 9 (Tubule formation = 3; Nuclear pleomorphism = 2, and Mitotic activity = 1). * TUMOR SIZE (GREATEST DIMENSION) : 3.5 CM (MEASURED GROSSLY) (SEE COMMENT) TUMOR NECROSIS: NOT PRESENT. MICROCALCIFICATIONS: FOCALLY PRESENT, ASSOCIATED WITH INVASIVE CARCINOMA, AS WELL AS, BENIGN DUCTS. VENOUS / LYMPHATIC INVASION: NOT IDENTIFIED.  MARGINS: NEGATIVE. DISTANCE OF TUMOR FROM NEAREST INKED BLACK (DEEP) TISSUE EDGE IS O.5 CM (SLIDE A7).  INTRADUCTAL COMPONENT: LOBULAR CARCINOMA IN SITU. * NIPPLE INVOLVEMENT: NOT PRESENT. *  SKIN INVOLVEMENT: NOT PRESENT. LYMPH NODES: ONE (1) SENTINEL LYMPH NODE NEGATIVE PER PRIOR SURGICAL SPECIMEN ESTROGEN RECEPTORS: POSTTTVE (95% NUCLEAR STAINING PER PRIOR SURGICAL SPECIMEN . PROGESTERONE RECEPTORS: NEGATIVE (NO DETECTABLE NUCLEAR STAINING PER PRIOR SURGICAL SPECIMEN * HER2/NEU: WEAKLY POSITIVE BY IMMUNOHISTOCHEMISTRY (2+). NEGATIVE BY FISH (HER2/CEP17 RATIO: 0.9) PER PRIOR SURGICAL SPECIMEN PATHOLOGIC STAGE: pT2 NO MX. ADDITIONAL PATHOLOGIC CHANGES: * FLORID USUAL DUCTAL HYPERPLASIA. FIBROADENOMATOID CHANGE. FIBROCYSTIC CHANGES TO INCLUDE STROMAL FIBROSIS, CYST FORMATION, AND APOCRINE METAPLASIA. * PRIOR BIOPSY SITE CHANGES Comment: The lobular differentiation is supported by negative E-cadherin cytoplasmic staining and strongly positive 34betaEl2 ( ) perinuclear cytoplasmic staining. There are microscopic foci of infiltrating lobular. carcinoma and Lcis in a random representative section of the lower outer. quadrant (slide Al0). The morphology is identical to the main tumor UUID:6860A718-FAAB-44A1-A3C1-E4A9EC1ECB05 TCGA-A2-A0ES-01A-PR Redacted Page 1 Continued on Next Page - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 2 ---
+FOR OFFICIAL USE ONLY - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: FINAL DIAGNOSIS (continued) : mass.  These foci likely represent extension of the main tumor rather than true multifocal carcinoma.. ** Report Electronically Signed Out ** CLINICAL DIAGNOSIS AND HISTORY: {None Given} GROSS DESCRIPTION: A. Received fresh labeled with the patient's name. and designated "LEFT BREAsT" is a 413 gram simple mastectomy specimen oriented with sutures (long lateral, short superior) measuring 22 cm medial to lateral, 16 cm superior to inferior, and 4.8 cm anterior to posterior. An. ellipse of unremarkable nipple bearing skin measuring 5.5 x 3 cm is present. The specimen is inked as foliows: blue superior superficial, green inferior superficial, black deep. Sectioning reveals a 3.5 x 3.5 x 3 cm firm poorly defined mass at the 2-3:00 position, 0.2 cm from the inked. deep margin. The cut surface of the tumor is yellow tan and gritty. The remaining tissue is mostly fatty with admixed patches of white fibrous tissue located centrally. Two sections of tumor, a single section of skin, and a single section of grossly normal breast are collected for CBcp protocol with matched paraffin sections in A2, A3, Al, and A4 respectively. The specimen was in formalin for 76 hours and 5 minutes. Summary of cassettes:. Al: skin A2: tumor lateral A3: tumor medial A4: grossly normal breast central. A5-A7: random additional sections of tumor. A8: left upper outer quadrant. A9: left upper inner quadrant Al0: left lower outer quadrant. All: left lower inner quadrant A12: nipple. Page 2 End of Report FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
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diff --git a/output/text/e33d86a2-0553-47f9-8e7d-09b8a2eba734.txt b/output/text/e33d86a2-0553-47f9-8e7d-09b8a2eba734.txt
new file mode 100644
index 0000000000000000000000000000000000000000..738e5d1322ea8c178b34b7bf3ceb553a78107be7
--- /dev/null
+++ b/output/text/e33d86a2-0553-47f9-8e7d-09b8a2eba734.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+Ciinical Diagnosis & History: Right lreast cancer with axillary positive FNA. Specimens Submitted: 1: sP: Right breast and axillary contents level 1 and 2 2: sP:Additional level one lymph node , right axilla DIAGNOSIS: 1. BREAST, RIGHT; MODIFIED RADICAL MASTECTOMY: - MULTIPLE FOCI INVASIVE DUCTAL CARCINOMA WITH NEUROENDOCRINE vurifiud by stniNs DIFFERENTIATION, HISTOLOGIC GRADE III/III (SLIGHT OR NO TUBULE FORMATION), NUCLEAR GRADE III/III (MARKED VARIATION IN SIZE AND SHAPE) RANGING IN SIZE prtss FROM 0.1 CM TO 4.2 CM. - THERE IS A DOMINANT TUMOR MASS WHICH MEASURES 4.2 CM IN GREATEST DIMENSION WITH MULTIPLE SATELLITE NODULES SPANNING AN AREA OF 9.O CM. - DUCTAL CARCINOMA IN-SITU (DCIS) IS ALSO IDENTIFIED, SOLID, FLAT/CLINGING, MICROPAPILLARY, AND CRIBRIFORM TYPES WITH INTERMEDIATE TO HIGH NUCLEAR GRADE AND MILD NECROSIS. - THE DCIS CONSTITUTES LESS THAN OR EQUAL TO 25% OF THE TOTAL TUMOR MASS, AND IS PRESENT ADMIXED WITH THE INVASIVE COMPONENT. UUID: 29C26285-D490-4125-9661-19033A8EC6A80 - THE INVASIVE CARCINOIMA IS LOCATED IN ALL FOUR QUADRANTS AND THE TCGA-A0-A033-01A-PR CENTRAL AREA. 'Redacted - THE DCIS IS LOCATED IN ALL FOUR QUADRANTS AND THE CENTRAL AREA. - SMALL FOCUS OF LOBULAR CARCINOMA IN SITU (LCIS) IS IDENTIFIED - NO INVOLVEMENT OF THE NIPPLE BY BITHER IN SITU OR INVASIVE CARCINOMA IS IDENTIFIED. - CALCIFICATIONS ARE PRESENT IN THE INVASIVE AND IN SITU CARCINOMA. NO VASCULAR INVASION IS NOTED. - NO INVOLVEMENT OF THE SURGICAL MARGINS BY EITHER INVASIVE OR IN SITU CARCINOMA IS IDENTIFIED. - NO SKIN INVOLVEMENT BY CARCINOMA IS IDENTIFIED. - BIOPSY SITE, FIBROCYSTIC, AND COLUMNAR CHANGES AND MICROSCOPIC INTRADUCTAL PAPILLOMAS ARE ALSO IDENTIFIED - THE LYMPH NODE STATUS IS AS FOLLOWS (EXPRESSED AS THE NUMBER OF POSITIVE LYMPH NODES IN RELATION TO THE TOTAL NUMBER OF LYMPH NODES EXAMINED) : LEVEL I: 0/23; LEVEL II: 0/11; INTRAMAMMARY (ELEVEN O' CLOCK): 1/1. - THE METASTATIC FOCUS MEASURES 1.9 CM. - THERE IS NO EXTRANODAL EXTENSION OF CARCINOMA. ** Continued on next page ** 1cs-0-3 Carcinomn, infidtnsHng dut mi xud w/ sthw typw (nuroinslrcriy 8523/3 S1fu: 5risst N0s C50.9 1/37/
+
+--- Page 2 ---
+2 LYMPH NODE, LEVEL ONE, RIGHT AXILLA, ADDITIONAL; EXCISION: ONE BENIGN LYMPH NODE O/1. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. *** Report Blectronically Signed Out *** Aross Description: M.D. 1) The specimen is received fresh and labeled. "right breast and axillary contents levels 1 and 2" and consists of a breast measuring 33.0 x 27.5 x 6.0 cm with overlying skin ellipse measuring 33.0 x 17.0 cm. Situated. centrally on the skin surface is a flattened nipple measuring 0.9 x 0.9 cm and areola measuring 4.2 cm. The skin shows bruising at the 8 o'clock positions. No definitive scars are appreciated. A suture demarcates the axillary contents which measures 11.0 x 6.5 cm. Two tags are present, designating levels 1 and 2.. black and the anterior/superior red and interior/inferior green. The The posterior surface of the breast is inked specimen is serially sectioned to reveal a firm tumor nodule measuring x 3.5 x 3.2 cm located centrally at the subareolar aspect, from the deep margin with surrounding firm satellite axtension involving a 4.2 9.0 x 5.5 x 5.0 cm area involving ali four quadrants. A full face section of located 1.0 cm the largest tumor nodule is taken, sectioned and submitted accordingly. Additional representative sections showing the satellite nodules are submitted. The remaining breast tissue shows, lobular adipose tissue with scant white fibrous breast tissue. The axillary tissue is dissected to 2 o'clock position, measuring 2.5 cm in greatest dimension with a grossly positive cut surface. A representative section of the lymph node is submitted. All identified lymph nodes are submitted. Representative sections are submitted. All dissected lymph nodes are entirely submitted. Summary of sections: N - nipple NB - nipple base - representative skin - tumor to deep margin D TSS tumor (full face, trisected). TN-- largest tumor nodule to surrounding papillary nodules PN-- surrounding papillary tumor nodules UIQ - - upper inner quadrant lower : inner quadrant UOQ - upper  outer LOQ - lower outer quadrant  quadrant LN11-- grossly positive l1 o'clock lymph node LN1-- lymph nodes (level 1). BLN1-- bisected lymph nodes (level 1) ** Continued on next page *.
+
+--- Page 3 ---
+TLN1-- trisected lymph nodes (level 1) SLNlserially sectioned single lymph node (level 1) Page LN2 - lymph nodes (level 2) BLN2-- bisected lymph node (level 2) 2) The specimen is received in formalin, labeled "Additional level 1 lymph node, right axilla" and consists of a single pink tan fatty lymph node measuring 1.2 x 1 x 0.3 cm. The lymph node is entirely submitted.. Summary of sections: LN- lymph node Summary of Sections: Part 1: SP: Right breast and axillary contents level 1 and 2 Block Sect. Site. PCs 4 BLN1 1 4 BLN2 1 1 D 2 LIQ 1 3 2 LN1 1 LN11 3 2 1 LN2 2 LOQ 2 3 N NB 1 M 4 1 SLN1 3 TLN1 2 3 TN 3 TSS 2 2 4 : UIQ 2 UOQ 22 Part 2: SP:Additional level one lymph node , right axilla Block Sect. site PCs LN 1 Procedures/Addenda: Addendum Date Ordered: Date Complete: Status: Signed Out Date Reported: By: D. Addendum Diagnosis ** Continued on next page
+
+--- Page 4 ---
+RIGHT BREAST AND AXILLARY CONTENTS, LEVEL 1 AND 2: IMMUNOHISTOCHEMICAL STAINS SHOW THE TUMOR CELLS TO BE NEGATIVE FOR HER2(G/1+) M.D. End of Report
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diff --git a/output/text/e34b3053-a89d-4441-bd1d-6d71a153b762.txt b/output/text/e34b3053-a89d-4441-bd1d-6d71a153b762.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1f8a29e4525fe0382081f42bb10b332410918ca9
--- /dev/null
+++ b/output/text/e34b3053-a89d-4441-bd1d-6d71a153b762.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Tumor: Normal: Addendum Discussion: Sections demonstrate gray and white matter with a moderately hypercellular, infiltrative, moderately atypical fibrillary astrocytes. Neither tumor necrosis nor microvascular. proliferation are seen.. Numerous MIB-1 reactive cells are present throughout the specimen. In the most. proliferative areas, a labeling index of 13.8% is calculated, consistent with a highly. proliferative high grade glial neoplasm . Addendum Diagnosis: Left Temporal and Periventricular tumor Anaplastic Astrocytoma (Grade III)  MIB-1 Labeling Index= 13.8% Microscopic Description: Permanent sections of the frozen section specimens demonstrate a moderately hypercellular, diffusely infiltrative astrocytic neoplasm. The tumor cells demonstrate. moderate to focally marked atypia. A few mitotiz figures are seen. There is no microvascular proliferation or necrosis.
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diff --git a/output/text/e34c1530-1725-493f-9f19-c41dceb0a872.txt b/output/text/e34c1530-1725-493f-9f19-c41dceb0a872.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e3edacf6aa5ac0734edde8f070140daef834eccf
--- /dev/null
+++ b/output/text/e34c1530-1725-493f-9f19-c41dceb0a872.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Not for Permanent Storage in Medical Records / Not Valid for Signing. Requested by: Patient MRN Date of Service Performing Facility Ordering Provider Result Provider. SURGICAL PATHOLOGY REPORT PROCEDURE DATE:  SPECIMEN DESCRIPTION: Right colon. =- PRE-OPERATIVE DIAGNOSIS: Carcinoma, right colon.  POST-OPERATIVE DIAGNOSIS: Same = CLINICAL INFORMATION: Same -= GROSS DESCRIPTION: The specimen consists of a segment of terminal ileum, cecum, appendix and. ascending colon with attached mesocolon and omentum. Multiple adhesions are seen on the surface of the specimen. The terminal ileum measures. approximately 7.0 x 3.0 cm. The colonic and ceca1 segment measures 15.0 x 2.5. cm. An area of induration and puckering is evident on the anterior aspect just above what appears to be ileocecal valve. Opening the colon reveals a large fungating ulcerated mass measuring approximately 8.0 x 9.0 cm involving the full circumference of the colon. It has a central area of ulceration and raised irregular erythematous edges. The appendix is dilated and measures 4.0. x 1.0 cm MICROSCOPIC DESCRIPTION: Sections through the tumor demonstrate a variable pattern. In areas, it consists of atypical glandular structures formed by cells with irregular and hyperchromatic nuclei. Additionally. areas consist of poorly differentiated tumor. Here, the cells form solids nests and cords of spindle and polygonal shaped cells without gland formation. The tumor invades the muscularis from an ulcerated mucosal surface and extends into serosal tissues where it is surrounded by a desmoplastic reaction. Sections through sixteen lymph nodes disclose lymphoid hyperplasia and reactive changes, but no metastatic tumor. The resection margins are free of tumor as well. The serosal surfaces of the bowel and appendix demonstrate chronic inflammatory changes. #sFINALDIAGNOSIS: == ASCENDING COLON WITH CONTIGUOUS TERMINAL ILEUM, CECUM AND APPENDIX: ADENOCARCINOMA OF ASCENDING COLON MODERATE TO UNDIFFERENTIATED SIXTEEN REGIONAL LYMPH NODES FREE OF TUMOR TUMOR PERMEATES BOWEL WALL AND EXTENDS TO PERICOLIC ADIPOSE TISSUE
+
+--- Page 2 ---
+Not for Permanent Storage in Medical Records / Not Valid for Signing Requested by: Patient MRN Date of Service. Performing Facility Ordering Provider. Result Provider. Report Name CHRONIC SEROSAL INFLAMMATION TUMOR SIZE - 9.0 CM TT3,NO,MX PROXIMAL DISTAL AND RADIAL MARGINS NOT INVOLVED LYMPHATIC AND VENOUS INVOLVEMENT IS NOT SEEN CODF 1.6 PATHOLOGTST The histologic grade of this tumor varies from well to undifferentiated.
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diff --git a/output/text/e3c11c9d-aa3f-4160-a2ad-f210105bf89d.txt b/output/text/e3c11c9d-aa3f-4160-a2ad-f210105bf89d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ae5843c8091be57c8104ba5260840b89b48e9c14
--- /dev/null
+++ b/output/text/e3c11c9d-aa3f-4160-a2ad-f210105bf89d.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+87F-A072-05E66D01842A TCGA-AC-A3HN-01A-PR Redacted SURGICAL PATHOLOGY REPORT Patient Name: Path No.: Med. Rec. #: Client: DOB/Gender: (Age: )F Cotlected: Locatlon: Received: Soc. Sec. #: Reported: Hosp #: Physiclan(s): Pre-Operative/Clinlcal History Left breast cancer. Specimen(s) Received A: LEFT AX!LLA SENTINEL LYMPH NODE #1 B: LEFT AXILLA SENTINEL LYMPH NODE #2 C: LEFT AXILLA, ADDITIONAL AXILLARY TISSUE 1es-0-3 D: BREAST, MASTECTOMY Ste: brast Nos c5o.9 pw i2f2fn Gross Description Specimen A, received in formalin labeled left axilla sentinel node #1, consists of adipose tissue, 3.5 x 1.5 x 1.3 cm.  Sections show a lymph node measuring 2.0 cm in greatest dimension, partially replaced by adipose-tissue. The node is sectioned and entirely submitted labeled (A1, A2). Specimen B, received in formalin labeled left axilla sentinel node #2, consists of adipose tissue, 2.0 x 1.5 x 0.8 cm.. Sections show a single lymph node candidate measuring 1.0 cm in greatest dimension. The node is sectioned and entirely submitted. (B1). Speclmen C, received In formalin labeled left axilla additional axillary tissue, consists of adipose.tissue, 4.0 x 2.5 x 2.0 cm. In aggregate. Sections show a single lymph node candidate, 0.3 cm in greatest dimension. (C1). Microscopic Descriptlon The microscopic findings are reflected in the diagnosis rendered. Diagnosis A) LYMPH NODE, LEFT AXILLARY SENTINEL #1, EXCISION: ONE LYMPH NODE INVOLVED BY METASTATIC MAMMARY CARCINOMA (9 MM, NEGATIVE FOR EXTRACAPSULAR EXTENSION). B) LYMPH NODE, LEFT AXILLARY SENTINEL #2, EXCISION: ONE LYMPH NODE INVOLVED BY MICROMETASTATIC MAMMARY CARCINOMA (1 MM, NEGATIVE : FOR EXTRACAPSULAR EXTENSION).. C) LYMPH NODE; LEFT AXILLARY NONSENTINEL, EXCISION: ONE LYMPH NODE NEGATIVE FOR TUMOR.
+
+--- Page 2 ---
+PHD HISTOLOGY REPORT Electronically Reviewed and Signed Out By Comment All sentinel node blocks were examined with three 80 um interval H&E stainer! conti.  and two 80 um interval cytokeratin AE1/AE3 immunostains. Positive and negative controls react satisfactorily. FDA requred disclaimer: These tests ware developed and their performance characteristics determined by Thoy have not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. These tosts are used for clinical purposes and should not be regarded as investigational or for research. This laboratory is certified under the Clinical Improvement. Amendments of 1988 (CLiA) as qualified to perform high compiexity clinical laboratory testing.  aquired information for predictive/prognostic markers: 1. Type of specimen fixation and detection system: Tissue is fixed in 10% formalln. Indrect biotin-tree detection kit is used. 2. Clones used: ER (clone 6F11) Novocastra; PR(clone PGR 636) DakoCytomation; CD117 (polyclonal, DakoCytomation); HER2 (clone 485, Ventana, FDA approved); K-87 (clone K3, Cell Marque) p53 (cione DO7. Novocastra), MSH6 (clone BC-44, Biocare), MSH2 (CellMarque clone G219-1129), MLH1 (Cell Marque clono G168-728), PMS2 (clone MRQ-28, Cell Marquej. 3. Criteria for posttve results: ER and PR: 1% of tumor cell with nuclear staining; HER2: >30% of cel's show complete mambrane staining;. p53: 10% of tumor cells with nucloar staining; MMR Proteins: complote absence of tumor nucleer staining. CPT Code(s) A: 88307, 88342, B: 88307, 88342, C: 88305 D: 88307, 3260F Procedures/Addenda ADDENDUM Addendum Comment Gross Descriptlon Specimen D is received in formalin labeled left breast, suture = axillary tail. Specimen type:. Mastectomy without axillary tail and without pectoralis muscle. The speclmen is oriented. by the surgeon as follows: suture = axillary tail. Specimen sizeldescrlption: : . 755 gm. SI 17.5 cm, ML 16.5'cm, AP 6.0.cm. Laterality: Left. Tumor size: 3.0 x 2:5 x 2.0 cm. Tumor site: Upper inner quadrant, 10-11 o'clock. Tumor descriptlon:  Stellate, gritty, tan-white with a central 1.0 x 1.0 x 0.7 cm hemorrhagic ill-defined biopsy site. Deep margin: 1.5 cm. Nipple/areolar complex:: The areola measures 3.5 cm with a centrally retracted 0.6 x 0.6 cm nipple. There is a: 5.5 ' x 4.0 cm area of blue dye superior the nipple/areolar area. Page 2 of !
+
+--- Page 3 ---
+PHD HISTOLOGY REPORT Skin: The ellipse measures 22.0 x 10.5 cm. Lymph node sampllng: Not applicable. Other: Sectioning of the surrounding breast tissue shows predominantly yellow lobular adipose  tissue admixed with dense, granular cystic breast tissue.. Sectlons are submitted as follows: (D1, 2) Nipple (D3-7) Mass (D8, 9) Upper inner quadrant. (D10, 11) Lower inner quadrant (D12, 13) Lower outer quadrant (D14, 15) Upper outer quadrant (D16, 17) Deep margin. EO:vyb ***Electronically Reviewed and Signed Out By ADDENDUM Addendum Diagnosis D) BREASt, LEft, TOtAL mASTeCTOmY: INVASIVE LOBULAR CARCINOMA, 3.0 CM, LOW COMBINED HISTOLOGIC GRADE WITH LOW PROLIFERATIVE RATE. SURGICAL MARGINS NEGATIVE FOR TUMOR (SEE COMMENT). Addendum Comment Summary of Pathologlc Findings Breast Carcinoma MIcroscopic Examinatlon. Specimen: Total breast. Procedure: Total mastectomy. Lymph node sampling: Sentinel node biopsies. Specimen Integrity: Single intact specimen. Specimen size: 17.5 cm greatest dimension. Laterality: Left. Tumor site:: Upper inner quadrant, 9-10 o'clock position per previous diagnostic core biopsy. Size of invasive component:  3.0 cm greatest dimension.. Tumor focality: Single focus. Page 3 of 5
+
+--- Page 4 ---
+PHD HISTOLOGY REPORT Macroscopic and microscopic extent of tumor:. Skin: Uninvolved. Nipple: Paget disease absent. Skeletal muscle: Not present. Histologic type:  Invasive lobular carcinoma. Combined histologic grade: Low combined histologic grade with low proliferative rate.  Tubule formation: 3. Nuclear pleomorphism:. 1. Mitotlc count: 1 (field area 0.23 mm?) Total Nottingham score: 5. Lymph-vascular invaslon: Absent. Ductal carcinoma in situ: Absent. Extensive intraductal component (EIC): Not applicable. Extent: Not applicable.. Lobular carcinoma in situ:. Absent. There are focal areas of atypical lobular hyperplasia.. Deep margin: Not involved. Lymph nodes: Number of sentinel nodes examined: 2. Total number of nodes examined: 3.  Number of nodes with macrometastasis: 1. Number of nodes with micrometastasis: 1. Number of nodes with isolated tumor cells: . 0.. Size of largest metastatic deposit: 9 mm. Extracapsular extension: Negative:  Method of evaluation:of sentlnel lymph nodes:. Three 80 um interval H&E stained sections and two 80 um interval cytokeratln AE1/AE3'immunohistochem!cal stains on all sentinel lymph node blocks. TNM stage: pT2 N1a. Ancillary studies (estrogen receptor. progesterone receptor, HER2/neu and Ki-67): Performed on previous specimen,. see report for results.. ***Electronically Reviewed and Signed.Out By ADDENDUM Page 4 of 5
+
+--- Page 5 ---
+PHD hIStOLOgy rEPORT Addendum Comment Total fixation time in formalin: 31.0 hours. ***Electronically Reviewed and Signed Out By * 4 END OF REPORT Page 5 of 5:
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diff --git a/output/text/e3cd7aec-65e2-470a-8502-76122ceb0a8d.txt b/output/text/e3cd7aec-65e2-470a-8502-76122ceb0a8d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c34322fc643f80992ea9e334a16eafd035eab53e
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+)cd-0-3 Carcmumna, hifiltrtng ouct N0S 8500|3 1218/10 Srti wde: bresst NuS c50.9 Tss: UUID:46EE72F9-2F59-413F-8278-7A073760F095 SPECIMENS: Redacted TCGA-E2-A152-01A-PR A. WLE RIGHT BREAST B. SLN 1 RIGHT AXILLA C. SLN 2 RIGHT AXILLA D. SLN 3 RIGHT AXILLA SPECIMEN(S): A. WLE RIGHT BREAST B. SLN 1 RIGHT AXILLA C. SLN 2 RIGHT AXILLA D. SLN 3 RIGHT AXILLA GROSS DESCRIPTION: A. WLE RIGHT BREAST Received fresh labeled with the patient's identification and "right breast needle localization" is a previously inked 99g, 9 x 8.5 x 3.4cm needle localized lumpectomy with 2 radiographs. Ink code: anterior-yellow, posterior-black, superior-  blue, inferior-orange, medial-green, lateral-red. Specimen is serially sectioned from lateral to medial into 10 slices revealing a 1.7 x 1.6 x 1.5cm tan pink well circumscribed mass at the posterior margin in slices 4-7. A second 0.5 x 0.5 x 0.5cm tan pink firm ill defined mass is identified, 0.3cm from the anterior-medial margin in slice 8, 1.9cm from the main mass. A portion of the specimen is submitted for tissue procurement. Representatively submitted:. A1-A2: lateral margin slice 1 A3: deep margin slice 2  A4-A5: next to mass with deep margin slice 3 A6-A8: deep margin with mass 1 in A6 slice 4 A9-A12: slice 5 with mass in A9 A13-A16: slice 6 with mass in A14-A15 A17: mass with deep margin slice 7 A18: anterior margin slice 7 A19-A21: slice 8 with mass 2 in A21 A22: next to mass 2 slice 9 A23: medial margin slice 10 B. SLN 1 RIGHT AXILLA  Received fresh is a tan pink lymph node 1.3 x 1.2 x 1cm. The specimen is serially sectioned and a touch prep is taken. Toto B1. C. SLN 2 RIGHT AXILLA  Received fresh is a tan pink lymph node 1.8 x 1.5 x 1.3cm. The specimen is serially sectioned and a touch prep is taken. Toto C1 D. SLN 3 RIGHT AXILLA  Received fresh is a tan pink lymph node 0.6 x 0.5 x 0.5cm. The specimen is serially sectioned and a touch prep is. taken. Toto D1. DIAGNOSIS:  A. BREAST, RIGHT, WIDE LOCAL EXCISION:  : INVASIVE DUCTAL CARCINOMA, SBR GRADE 3, MEASURING 1.8-CM  - HIGH NUCLEAR GRADE, DUCTAL CARCINOMA IN SITU, SOLIDE AND CRIBRIFORM TYPES WITH CENTRAL NECROSIS AND MICROCALCIFICATIONS - INVASIVE TUMOR PRESENT 0.15-CM FROM POSTERIOR SURGICAL RESECTION MARGIN - BIOPSY SITE CHANGES WITH FIBROSIS - SEE SYNOPTIC REPORT AND SEE NOTE B. LYMPH NODE, SENTINEL #1, RIGHT AXILLA, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1). C. LYMPH NODE, SENTINEL #2, RIGHT AXILLA, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1) D. LYMPH NODE, SENTINEL #3, RIGHT AXILLA, EXCISION:E - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1).E  NOTE: Two nodules are grossly identified, larger located superior posterior and smaller located inferior anterior and.  more medial. Both tumors have the same histomorphology. The larger nodule extends from slice #4 to slice #7. The smaller nodule is located in slice #8. The tissue in between these two nodules shows DCis. Therefore, given
+
+--- Page 2 ---
+the presence of DCIS between these two tumors and having the same histomorphology, these tumors are considered connected. The largest confluent tumor size is 1.8-cm. SYNOPTIC REPORT - BREAST Specimen Type: Excision Needle Localization: Yes - For mass Laterality: Right Invasive Tumor: Present Multifocality: WHO CLASSIFICATION Invasive ductal carcinoma, NOs 8500/3 Tumor size: 1.8cm Tumor Site: Not specified Margins: Negative Distance from closest margin:. 0.15cm deep Tubular Score: 3 Nuclear Grade: 3 Mitotic Score: 2 Modified Scarff Bloom Richardson Grade: 3 Necrosis: Absent Vascular/Lymphatic Invasion: None identified Lobular neoplasia:  None Lymph nodes: Sentinel lymph node only Lymph node status: Negative 0/3 DCIS present Margins uninvolved by DCIS DCIS Quantity:Estimate 15% DCIS Type: Solid Cribriform DCIS Location:Associated with invasive tumor Nuclear grade: High Necrosis: Present Location of CA++: DCIS ER/PR/HER2 Results ER: Positive  PR: Negative HER2: Positive by IHC Performed on Case: Pathological staging (pTN): pT 1c N 0 CLINICAL HISTORY: Biopsy of proven cancer at wire- possible second lesion 2cm, medial to premarked tumor at triple stitch. PRE-OPERATIVE DIAGNOSIS: Right breast cancer. INTRAOPERATIVE CONSULTATION: A. GROSS ExAMINATION: Mass abuts the posterior margin, 2nd lesion is 0.3cm from the medial margin. Diagnosis called to Dr. at Dy Dr. TPB-TPC-TPD: No tumor seen. Diagnosis called to Dr. at I Dr.. Gross Dictation: Final Review: Pathologist. Final: Pathologist,
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diff --git a/output/text/e4003c10-5239-40a8-b79f-da00868622ee.txt b/output/text/e4003c10-5239-40a8-b79f-da00868622ee.txt
new file mode 100644
index 0000000000000000000000000000000000000000..62bbac56b69d803425e37c4a47c8adf720562399
--- /dev/null
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@@ -0,0 +1,27 @@
+
+--- Page 1 ---
+IcD 6-3 COrcinomo, In filtrating FINAL PATHOLOGIC DIAGNOSIS Wuetal NoS 85o A. Breast, left; modified radical mastectomy: Site: @Breas+ N6S - Invasive ductal carcinoma, SBR grade 2, see parameters C 50.9 H Q)18)i3 - Ductal carcinoma in situ, intermediate grade, solid and cribriform types with associated necrosis UUID: 7507AC79-4C8E-4393-9289-BFA68E8492D0 - Surgical margins free of tumor TCGA-OL-A5RU-01A-PR Redacted - Biopsy site changese - Fourteen nodes, negative for carcinoma (0/14) - Nipple, areola, and skin without diagnostic abnormality B. Breast, right; simple mastectomy: - Invasive ductal carcinoma, SBR grade 2, inferior-anterior of hematoma cavity, see parameters - Extensive ductal carcinoma in situ, intermediate grade, solid type, with associated central necrosis - Anterior-inferior margin positive for invasive carcinoma. - Attached skeletal muscle focally infiltrated by invasive carcinoma (anterior-inferior) - Columnar cell change and adenosis. - Intraductal papilloma - Nipple, areola, and skin without diagnostic abnormality Breast Pathologic Parameters (Part A Left Breast) 1. Invasive carcinoma: A. Gross measurement: 1.9 x 1.5 x 1.5 cm
+
+--- Page 2 ---
+B. Composite histologic (modified SBR) grade: II. - Architecture: 2 - Nuclear grade: 3 - Mitotic count: 1. C. Associated intraductal carcinoma in situ (Dcis): - Within main mass (forming 10 % of tumor volume). - Extending away from main lesion. 2. Intraductal carcinoma: A. Gross or microscopic (specify) measurement: (5.2 cm, spanning 4 slices) B. Type: Cribriform and Solid C. Nuclear grade: Intermediate D. Associated features: Necrosis 3. Excisional biopsy margins: Free of tumor - DCis 4 mm from posterior margin. - Invasive carcinoma 5 mm from posterior (closest) margin. 4. Blood vessel and lymphatic invasion: Not identified. 5. Nipple: unremarkable 6. Skin: uninvolved.
+
+--- Page 3 ---
+7. Skeletal muscle: Focally present, negative for tumor 8. Axillary lymph nodes: In combination with previous sentinel lymph node biopsy. (see One of fifteen nodes positive for carcinoma (1/15) - Size of largest metastatic deposit: 18 mm - Extranodal extension: present (2 mm; largest focus) 9. Special studies (see - ER: Positive expression in >95% of invasive tumor nuclei. - PR: Positive expression in 80% of invasive tumor nuclei - Her2/neu antigen (FIsH): Non-amplified (1.02) 10. pTNM (AJCC, 7th edition, 2010): pT1cN1MX Effective this Checklist utilizes the 7th edition TNM staging system for breast of the American Joint Committee on Cancer (AJcC) and the International Union Against Cancer (UIcC). Breast Pathologic Parameters (Part B Right Breast) 1. Invasive carcinoma: A. Microscopic measurement: 1.5 cm B. Composite histologic (modified SBR) grade: II - Architecture: 3 - Nuclear grade: 2
+
+--- Page 4 ---
+- Mitotic count: 1 C. Associated intraductal carcinoma in situ (Dcis): - Within main mass (forming 50 % of tumor volume) - Extending away from main mass 2. Intraductal carcinoma: A. Microscopic measurement: 6.1 cm, spanning over 5 slices, involving lower inner and upper inner quadrants and extending anteriorly towards nipple B. Type: Solid C. Nuclear grade: Intermediate D. Associated features: Necrosis and cancerization of lobules 3. Excisional biopsy margins: Positive - Dcis >3 mm from posterior and inferior (closest) margins - Invasive carcinoma at inferior-anterior margin with infiltration of attached skeletal muscle.. 4. Blood vessel and lymphatic invasion: Suspicious 5. Nipple: unremarkable;DciS noted 5 mm from areolar complex 6. Skin: uninvolved 7. Skeletal muscle: Focus attached inferior-anterior infiltrated by carcinoma.
+
+--- Page 5 ---
+8. Axillary lymph nodes: Negative (Two sentinel nodes, negative for carcinoma (0/2), see 9. Special studies (see - ER: Strong expression in >90% of invasive tumor nuclei - PR: Strong expression in >90% of invasive tumor nuclei - Her2/neu antigen (FIsH): Non-amplified (1.04) 10. pTNM (AJCC, 7th edition, 2010): pT1cN0(sn)MX (pending review of imaging) Effective this Checklist utilizes the 7th edition TNM staging system for breast of the American Joint Committee on Cancer (AJcc) and thee International Union Against Cancer (UIcC) Clinical History: The patient is a 'ear old female with malignant neoplasm of the breast. undergoing left modified radical mastectomy and right simple mastectomy. bi 1ater al iuctal Cnsuismo Comment B. Stains for CKAE1/AE3 and myosin-heavy chain support extension of invasive carcinoma into skeletal muscle at the inferior-anterior aspect of the breast.
+
+--- Page 6 ---
+Findings were discussed with Specimens Received: A: Left modified radicalmastectomy; mastectomy B: Right simple mastectomy; partial mastectomy Gross Description: Received are two containers, each labeled with the patient's name and medical record number. A. Container A is further designated '1. Left modified radicalmastectomy; mastectomy.' The radiographic findings for this breast include an irreglarly shaped mass measuring 1.4 x 1.2 x 1.9 cm and areas of heterogenous kinetics with washout. The total extent of the abnormal enhancing is 2.8 x 2.3 x 1.9 cm. Received fresh and placed in formalin is a 468 gram mastectomy specimen measuring 14.5 cm from medial to lateral, 17.5 cm from superior to inferior and 3.7 cm from anterior to posterior. It has an axillary tail measuring 11 x 6.5 x 1.5 cm. The skin measures 13.2 x 5 cm and an nipple areola complex measuring 3 x 2.7 cm and a nipple measuring 1 x 1 cm. The specimen is inked as follows:
+
+--- Page 7 ---
+ posterior black, anterior-superior yellow, anterior-inferior green. It is sliced into 11 slices to reveal a lesion that is present from slices 6 to 8 and the lesion measures 1.9 x 1.5 cm and has a medial to lateral dimension of 1.5 cm. It focally abuts the deep margin and is 3 cm from the inferior margin and 9 cm from the superior margin. No other lesions or masses are identified. A  number of lymph node candidates are identified in the axillary tail, the largest of which measures 2.5 x 2 x 1.8 cm. This large lymph node is sectioned to reveal a central area of necrosis. Block Summary: A1-A3: lesion from slice 6 A2: superior to lesion A3: inferior to lesion A4: lesion in slice 7 A5: lesion in slice 8 A6: slice 5 next to lesion A7: slice 9 next to lesion A8: skin and nipple A9: areola A10: upper-inner quadrant from slice 2 A11: lower-inner quadrant from slice 4 A12: upper-outer quadrant from slice 7 A13: lower-outer quadrant from slice 7 A14: three lymph node candidates A15: three lymph node candidates
+
+--- Page 8 ---
+A16: three lymph node candidates A17: three lymph node candidates A18: one lymph node candidate A19: one lymph node candidate A20-A21: largest lymph node candidate bisected A22-A25: additional representative sections of axillary fat B. Container B is further designated '2. Right simple mastectomy; partial mastectomy.' Received fresh and placed in formalin is a 350 gram mastectomy specimen measuring 17 cm from medial to lateral, 13.5 from superior to inferior, and 2.5 cm from anterior to posterior. There is a skin ellipse  measuring3 x 3.5 cm and an areola measuring 2.5 x 2.7 cm and a nipple measuring 1 x 1 cm. It is sliced into 14 slices in which there is a hematoma cavity measuring 1.5 x 1.5 x 3.1 cm found in slices 3, 4, 5 and 6. The cavity has a rim of white-tan, firm tissue around it and the cavity is 1.1 cm from the deep margin and 0.6 cm from the inferior margin. Also note that the deep margin is. inked red, the anterior-superior margin is inked blue and the anterior-inferior. margin is inked green. No other lesions or masses are identified. Block Summary: B1: lesion in slice 3 B2: superior to B1 B3: lesion in slice 4 B4: superior to B3 B5: lesion in slice 5
+
+--- Page 9 ---
+B6: superior to B5 B7: lesion in slice 6 B8: superior to B7 B9: slice 7 adjacent to lesion. B10: slice 2 adjacent to lesion. B11: upper-outer quadrant in slice 12 B12: lower-outer quadrant in slice 11. B13: upper-inner quadrant in slice 5 B14: lower-inner quadrant in slice 6 B15: skin and nipple B16: areola The specimen is inked as follows: posterior red, anterior-superior blue, anterior inferior green.. The tissue is fixed for at least six hours in NBF and no more than 72 hours. 20
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diff --git a/output/text/e405f94d-a3af-49b8-be98-fe6555a2760a.txt b/output/text/e405f94d-a3af-49b8-be98-fe6555a2760a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b69aff779ce520436f489bd4cf57634b2bf32489
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+
+--- Page 1 ---
+IcDO3 UUIDB8E026C7 Redacted Courenoms, rensS ciIl Cu5msphobe type 8317l3 Sit. RKidney NOS Surgical Pathology Report C649 JJ 9/z4|13 Diagnosis: Kidney, right, nephrectomy. - Renal cell carcinoma, chromophobe type. - Furhman nuclear grade: 2. - Tumor size: 3.3 cm. - Extent of involvement: Tumor is confined to the kidney. - Angiolymphatic and perineural invasion: Absent. - Margins: Negative. Clinical History: The patient is a -year-old Caucasian female with a right renal mass who undergoes laparoscopic nephrectomy. Gross Description: Received in a formalin-filled container, additionally labeled "R kidney". Specimen fixation: Formalin Type of specimen: Partial laparoscopic nephrectomy Side of specimen: Right Size and weight of specimen: 185 grams, 10 x 5.3 x 3.2 cm (post fixation) kidney with a 14 x 5 x 2.5 cm portion of attached perinephric fat. This fat is only attached near the hilum and focally at the superior and inferior poles. It is not clear grossly how this fat is oriented on the specimen. Presence/absence of adrenal gland: Absent Tumor description/site: There is an upper pole, medullary mass, which is compressing both the medulla. cortex and pelvis. The mass is variegated, bright orange, and dark brown and hemorrhagic and soft. The renal capsule is intact and the external surface of the kidney overlying the tumor is inked black. Tumor size: 3.3 x 2.5 x 1.3 cm Presence/absence of multicentricity: Absent
+
+--- Page 2 ---
+Confinement/non-confinement to the kidney: Confined Extent of invasion: Perirenal adipose tissue: Tumor does not grossly involve Gerota' s fascia: Tumor does not grossly involve. Renal vein: Tumor does not grossly involve Ureter: Tumor does not grossly involve Other organs: N/A Surgical margins: Perirenal adipose tissue: Negative Renal vein: Negative. Renal artery: Negative. Ureter: Negative Description of kidney away from tumor: The remainder of the renal parenchyma is brown/tan with a distinct corticomedullary junction and the cortex measuring 3 mm on average and the medulla. measuring 1.5 cm. There is no evidence of papillary necrosis. The external upper pole. is remarkable for a 1.3 x 0.2 cm small caliber tubular structure (? Vessel) by extending out from the. upper pole, hilar surface.. Lymph nodes (hilar): The hilar adipose tissue is palpated for lymph node candidates, however, no lymph. nodes are identified.. Comment: The perirenal adipose tissue is unremarkable except for a hemorrhagic external surface. The fat is freely moveable over the surface. Block Summary: A1 - Ureter and hilar vascular margins, en face A2 - Tumor and black inked external surface, cross. section of upper pole, small caliber vascular structure A3 - Additional tumor and capsule A4 - Tumor and normal kidney A5 - Normal kidney, lower pole Light Microscopy: Light microscopic examination is performed by Dr.. Immunostains were performed on A3. The tumor cells show strong reactivity for CD117 and focal staining for CK7. Stains for CK20, CD10, CD15, and vimentin are all negative. These findings support a diagnosis of chromophobe RCC and argue against a diagnosis of oncocytoma.. Histologic tumor type/subtype: renal cell carcinoma, chromophobe. Histologic grade (if applicable): grade 2 of 4; focally, there is higher grade atypia.
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diff --git a/output/text/e42fbd21-0871-40d2-b991-7df44da2b4e6.txt b/output/text/e42fbd21-0871-40d2-b991-7df44da2b4e6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e9b26e5e6210d5fd807550faa24317be6e31af6c
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Internal Sample I Diagnosis: This is a metastasis of a poorly differentiated adenocarcinoma in the region of the liver in 1), in II) an invasive adenocarcinoma of the colon, moderately differentiated, with infiltration of all parietal layers and vascular infiltration (pT3, L1, V1), as well as free resection margins and free lymph nodes (pN0) Comment: In the preparation of further sections, two liver metastases were discernible. These lay very close together. Tumor formula: ICDO-DA M-8140/3 G2 pT3, L1, V1, pN0 (0 of 13), pM1 (hepar) 1Cs-0-3 8/40/3 Aclenocacneme no S 3/8/11 pn Cqcz Site: pigmo'd coloy 6.18. 7 UUID:18C139E3-62C0-4D98-8D1B-BA412EE9BE1E TCGA-AA-A02-01A-PR Redacted
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diff --git a/output/text/e4c38b7d-3ceb-493e-a226-772d1a593782.txt b/output/text/e4c38b7d-3ceb-493e-a226-772d1a593782.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8fc984208374d1a279812c4629837d1890d7f3cd
--- /dev/null
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+
+--- Page 1 ---
+SURGICAL PATHOLOGY REPORT Clinical Diagnosis & History: with sigmoid adenocarcinoma.. Specimens Submitted: 1: Sigmoid colon and upper rectum; resection 2: Distal ring 3: Proximal ring DIAGNOSIS: 1. Sigmoid colon and upper tion Tumor Type: Adenocarcinoma Histologic Grade:  Moderately differentiated Tumor Location: Sigmoid colon Tumor Size: Length is 2 cm Width is 1.5 cm Maximal thickness is 0.6 cm. Tumor Budding: Absent Increased Tumor Infiltrating Lymphocytes:. Absent Precursor Lesions: Tubular adenoma Deepest Tumor Invasion: Subserosal adipose tissue and/or mesenteric fat Gross Tumor Perforation:. Not identified Lymphovascular Invasion: Not identified Large Venous Invasion: Not Identified Perineural Invasion: Not identified Surgical Margins: Free of tumor Polyps/Mucosa Dysplasia (away from the carcinoma): Not Identified ** Continued on next page **
+
+--- Page 2 ---
+Page 2 of 3 Non-Neoplastic Bowel: Unremarkable Lymph Nodes: Number with metastasis: 1 Total number examined: 17 Tumor c deposits in pericolorectal soft tissue: Not Identified Tumor Staging (AJcc 7th Edition) : pT3 (Tumor invades through the muscularis propria into pericolorectal tissues) Lymph Node Stage (AJcc 7th Edition): Nla (Metastasis in one regional lymph node). Rectum, distal ring; excision: - Benign segment of rectum with no pathologic diagnosis.. 3. Colon, proximal ring; excision: - Benign segment of colon with no pathologic diagnosis.. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT.S Gross Description: 1. The specimen is received fresh, labeled "sigmoid and upper rectum, open end is proximal". It consists of a rectosigmoid colon that measures 19 cm in length and 5 cm in diameter. The serosal surface is pink and glistening. The. radial resection margin is inked black and the specimen is opened to reveal a tumor that is located 12 cm from the proximal margin and 5.5 cm from the distal margin. The tumor measures 2 cm in length and 1.5 cm in width. Serial. sectioning reveals tumor invasion to a depth of 0.6 cm, which is 2.5 cm from. the closest radial margin. The remaining mucosa is grossly unremarkable. Pericolic and peri-rectal adipose tissue is thoroughly examined for lymph. nodes, and all possible nodes are submitted. Representative sections are submitted. Tps is submitted. The specimen is submitted for lymph node dissection. Summary of sections: PM - proximal margin DM -  distal margin RM - radial margin T - tumor U - uninvolved mucosa LN - lymph nodes BLN  - bisected lymph node ** Continued on next page **
+
+--- Page 3 ---
+ Page 3 of 3 2. The specimen is received in formalin, labeled "Distal ring" and consists of a ring of bowel measuring 1.0 cm in length and 1.5 cm in diameter. It has a stapled line through the middle. The mucosal surface is pink tan and focally hemorrhagic and the serosal surface is pink tan and smooth. The staples are removed and the soft tissue is entirely submitted. Summary of sections: U - undesignated 3. The specimen is received in formalin, labeled "proximal ring" and consists of a silver metal anastomotic pin measuring 5.5 x 2.8 x 1.5 cm. At the center of the pin, a blue plastic piece is noted.  A ring of pink tan soft tissue is attached measuring 1.5 x 1.4 x 1.0 cm. The mucosal surface is pink tan and focally hemorrhagic and the serosal surface is pink tan and smooth. Several sutures are noted. The sutures are removed and the soft tissue is entirely submitted. Summary of sections: U - undesignated Summary of Sections: Part 1: Sigmoid colon and upper rectum; resection Block Sect.  Site PCs 1 dm 1 6 LN 14 1 pm 1 1 rm 1 3 t 1 Part 2: Distal ring Block Sect.  Site pCs 1 U 1 Part 3: Proximal ring Block Sect. Site PCs 1 U 1 ** End of Report 
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diff --git a/output/text/e4f8364e-b5e8-4a91-99e0-77db91cb13fa.txt b/output/text/e4f8364e-b5e8-4a91-99e0-77db91cb13fa.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d6ea31c43fb85829fafd70b5389316c755d96dcb
--- /dev/null
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+
+--- Page 1 ---
+id-0-3 Carcinoma,mnfiltrak`Ng duct,N0s 85ov|3 PATIent hIStOry: S.te Code.? The patient is a . year-old female. Date of last menstrual period: Not given.. PRE OP DIAGNOSIS: Ca left breast. CQcF : 5rusF,Nos c50.9 POST OP DIAGNOSIS: Same. UUID: 2616F70D-3E15-45BA-8907-65694595F7260 TCGA-BH-A18U-01A-PR Redacted PROCEDURE: Sentinel node biopsy, total mastectomy. ADDENDA: Addendum ESTROGEN/PROGESTERONE AND HER-2INEU REPORT Using appropriate positive and negative controls, the test for the presence of these hormone receptor proteins is  performed by the immunoperoxidase method, and reported according to the N!H consensus statement on adjuvant. therapy for breast cancer, ot A positive ER or PR tumor shows any nuclear immunostaining, and is.  semiquantitated as Indicated below. Result Semiquantitative Statement ER positive Percent cells staining as: (0 20%; 1+ 30%, 2+ 30%, 3+ 20%) PR positive Percent cells staining as: (0 70%, 1+ 10%, 2+ 10%, 3+ 10%) HER-2/NeU DAKO hERCePTESt: A STrONG COMPLETE mEmBrANE STAINING IS OBSERVED IN MORe ThAN 10% OF THE TUMOR CELLS. HER-2IneU IS inTeRPReTED AS STRONGly POSITIVE (SCORE 3+). FINAL DIAGNOSIS: Part 1: Left Breast, tOtal mastectomy -  InFILTRATing Quct.CARcINOmA, TWQ LeSiONS, 2.6 X 1.7 X 1.5 Cm in The LOWER OUteR QUADRant ) :AND 3.0 X 2.8 X 2.5 Cm IN THE uppER OUTER QUADRAnT. nOTTInGhAm SCORE 9 OUt OF 9 (TuBuLES 3, NUClEI 3, MITOSiS 3). B.  LYMPHOVASCULAR INVASION IDENTIFIED. C. DUCtAL CARCinOmA IN-SiTU, SOLID TYPE, nUCLEAR GRADE 3 WITH COmeDO-TYPE NECROSiS, COMPRISINg LeSS THaN 5% Of tUmOR. D.  SURGICAL MARGINS NEGATIVE FOR INFILTRATING DUCT CARCINOMA AND DUCTAL CARCINOMA IN-E SItU. E.  INFILTRATING DUCT CARCINOMA FOCALLY APPROACHES VERY CLOSELY MARGIN OF EXCISION INS The Lower Outer Quadrant (within o.2 cm). . F.  NIpple negative for tumor. G.  Changes consistent with previous core biopsy site.  TWO LYMPH NODES, POSITIVE FOR METASTATIC CARCINOMA (2 OUT OF 2). H. PARt 2: LEft BREASt, nEW AnTeRIOR-InfERiOR MArGin, EXCISiON --  SKIN AND SUBCUTANEOUS TISSUE, NEGATIVE FOR TUMOR. PArt 3: Left Sentinel Lymph nODe #1, BiOpSy - ONE LymPH nODE POSITIVE fOR METASTATIC CARCInOmA (1 OUT OF 1). PART 4: LEFT SENTiNEL LyMPH NODE #2, BIOPSY - One Lymph nODe nEgaTIve fOR metaStatiC CARcinOmA (0 Out Of 1). Part 5: Left sentinel Lymph node #3, Biopsy -  One Lymph nODE pOsitIvE fOr metAstatIc CarcINoma (1 Out Of 1). Part 6: Left AxIlLary COntents, excIsiOn -- FIVE OF ELEVEN LyMPH NODeS POSITIVE fOR METASTATIC CARCINOMA, THREE WITH EXTRACAPSULAR EXTENSION. PART 7: RIGHT BREAST TISSUE, EXCISION (396 GRAMS) - A.  FOCAL ATYPICAL DUCTAL HYPERPLASIA ASSOCIATED WITH MICROCALCIFICATIONS B. CALCIFIED FIBROADENOMA. C. FIBROCYSTIC CHANGES WITH MICROCALCIFiCATIONS. SCLEROSING ADENOSIS. D Criteria E. SCLEROSING INTRADUCTAL PAPILLOMA. UNREMARKA8LE SKIN. COMMENT: Estrogen receptor, progesterone receptor and HER-2/neu immunostains will be ordered and subsequently reported in an addendum. Immunostaining for e-cadherin and myosin heavy chain confirm the interpretation of changes in the right breast tissue.
+
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+SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREASTE A. Laterality: 2 1.Right 2. Left B. Procedure: 2 1. Segmentectomy 3. Modified radical mastectomy 2. Simple mastectomy 4. Re-excision C. Location: 4.2 1. Central subareolar 4.LOQ 2. U0Q 3. UIQ 5. LIQ 6. Not specified E. Type (invasive component): 1 1. Ductal, NOS 2. Tubular 5. Cribriform  9. Metaplastic 6. Papillary 3. Mucinous 10. Other 7. Lobular 4. Medultary 8. Carcinoid like F. If lobular carcinoma, specify type: N/A 1: Classical 4. Signet ring 2. Solid 7. Pleomorphic  3. Alveolar 5. Trabecular G. Nottingham Score: 6. Tubulobular G1. Nuclear grade: 3 G2. Tubule formation: 3 G3. Mitotic activity score: 3 G4. Total Nottingham score: 9 G5. Nottingham grade (1, 2. 3): # H. Angiolymphatic invasion: 2 1. No 2. Yes I. Dermal lymphatic invasion: 2 1. Yes 2.No 3. Not applicable J. Calcification:1 1. No 2. Yes -- benign zones  3. Yes -- malignant zones K. Type of in situ component: 2 1. Cribriform 4. Micropapillary : 7. Lobular 2. Solid 5. Apocrine 3. Papillary 6. Comedo L. . Percentage of tumor occupied by in situ component:  5% M. Surgical margins involved by invasive component:. 1. No 1 2. Yes - focal 3. Yes -- diffuse N. Surgical margins involved by in situ component: 1. No 2. Yes - focal 3. Yes - diffuse O. Paget's disease of nipple: 2 1.Yes 2. No P. Number of positive lymph nodes:9 Q. Total number of lymph nodes examined: 16 R. Sentinel node metastasis: 1 1. Yes 2. No S. Only micrometastases to lymph nodes (none larger than 0.2 cm): 2 1. Yes 2. No T. Metastasis/es to a lymph node 2 cm. or more in greatest dimension: 1 1. Yes 2. No U. Lymph node metastasis/es with extracapsular extension:1 1. Yes 2. No V. Metastases to ipsilateral internal mammary lymph node (if applicable):  N/A 1. Yes 2. No W. Skin involved (ulceration): 2 1. Yes 2. No X. Non-neoplastic breast tissue: 6/#/#/# 1. ADH 4. Fibroadenoma 2. ALH 7. LCIS 5. Papilloma 8. Other 3. Radical scar 6. FCD Y. Multicentricity/multifocality of invasive foci: 1 1. Yes 2. No Z. TNM stage:T3#N 2a#M X#
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diff --git a/output/text/e50114b9-4d89-4936-b1ff-5070b6a62ca5.txt b/output/text/e50114b9-4d89-4936-b1ff-5070b6a62ca5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2b58c7b34c6f8c8545c67a8fd458884ae3a381e0
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+UUID:95443906-A63B-4E07-8C4A-ED0A918888F8 TCGA-E2-A1IE-01A-PR Redacted TSS ID SPECIMENS: A. SENTINEL LYMPH NODE RIGHT AXILLA #1 JCs - 0-3 B. SLN RIGHT AXILLA #2 C. SLN RIGHT AXILLA #3 D. EXC. RIGHT BREAST CA. Site. brot, nos C50.9 SPECIMEN(S): 48/ A. SENTINEL LYMPH NODE RIGHT AXILLA #1 B. SLN RIGHT AXILLA #2 C. SLN RIGHT AXILLA #3 D. EXC. RIGHT BREAST CA. GROSS DESCRIPTION: A. SENTINEL LYMPH NODE RIGHT AXILLA #1 Received fresh is a tan pink lymph node 0.5 x 0.5 x 0.3cm. The specimen is bisected and 2 touch preps. are taken. Toto A1. B. SLN RIGHT AXILLA #2 Received fresh is a tan pink lymph node 1.5 x 0.5 x 0.5cm. The specimen is bisected and 2 touch preps are taken. Toto B1. C. SLN RIGHT AXILLA Received fresh is are 3 tan pink lymph nodes ranging from 0.5cm to 1.2cm in greatest dimensions.. Each specimen is bisected and touch preps are taken. Toto C1. D. EXCISION RIGHT BREAST: Single Stitch-Anterior/Double Stitch-Lateral/Triple Stitch-Superior Received fresh is a 59g oriented tan pink WLE breast specimen, 7.0cm from superior to inferior, 6.0cm from anterior to posterior and 5.5cm from medial to lateral. The specimen is inked as follows: Red-. Superior, Orange-Inferior, Biue-Anterior, Black-Posterior, Green-Medial, Yellow-Lateral. The specimen is serially sectioned from lateral to medial into 7 slices; slice 1 being most lateral, slice 7 being most medial. The cut surface reveal a gray white firm well circumscribed mass 2.1 x 1.7 x 1.5cm, 0.6cm from the closest superior margin, located in slices 3, 4 and 5. A surgical clip is identified in slice 3. The. mass is 0.9cm from the deep margin and greater than 1.0cm from the remaining margins. The remaining cut surfaces reveal yellow lobulated adipose tissue interspersed with gray white fibrous tissue. A portion of the specimen is submitted for tissue procurement. Representative sections are. submitted as follows: D1: lateral margin, perpendicular sections taken from superior to inferior, slice 1. D2: area adjacent to mass with deep margin, slice 2 D3: mass with anterior/superior margin, slice 3 D4: mass with superior/deep margin, clip identified, slice 3. D5: anterior/inferior margin, slice 3. D6: inferior/deep margin, slice 3 D7: mass with superior and anterior margin, slice 4 D8: anterior/inferior, slice 4 D9: mass with superior and deep margin, slice 4 D10: inferior/deep margin, slice 4. D11: superior/deep margin, slice 5. D12: anterior/superior margin, slice 5. D13: anterior margin, slice 5 D14: area next to mass with anterior and deep margin, slice 6 D15: anterior margin, slice 6 D16: deep margin, slice 6 D17: medial margin, perpendicular sections submitted from superior to inferior, slice 7. As per attached diagram DIAGNOSIS:E A. SENTINEL LYMPH NODE #1, RIGHT AXILLA, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR CARCINOMA (0/1). B. SENTINEL LYMPH NODE #2, RIGHT AXILLA, BIOPSY: - MICROMETASTATIC CARCINOMA (1.5 MM) IN ONE LYMPH NODE (1/1) (SEE NOTe).
+
+--- Page 2 ---
+TSS ID NOTE: The metastasis is subcapsular. No extranodal extension is seen; however, there is cautery artifact at one edge of the metastasis limiting evaluation. The touch prep slides were reviewed and show no evidence of metastasis. Dr. has reviewed specimen B. C. SENTINEL LYMPH NODE #3, RIGHT AXILLA, BIOPSY: - ONE LYMPH NODE, NEGATIVE FOR CARCINOMA (0/1). D. BREAST, RIGHT, WIDE LOCAL EXCISION: - INVASIVE DUCTAL CARCINOMA, MODERATELY DIFFERENTIATED (SBR GRADE 2) WITH FOCAL NECROSIS (SEE NOTE). - TUMOR MEASURES 2.1 X 1.7 X 1.5 CM. - INVASIVE CARCINOMA IS 0.3 CM FROM POSTERIOR MARGIN. - LYMPHVASCULAR INVASION IS IDENTIFIED.S - DUCTAL CARCINOMA IN SITU (DCIS), SOLID AND CRIBRIFORM TYPES, NUCLEAR GRADE 2-3, WITH FOCAL NECROSIS. - ATYPICAL DUCTAL HYPERPLASIA. NOTE: Microcalcifications are seen in vessels and non-neoplastic breast tissue.. SYNOPTIC REPORT - BREAST Specimen Type: Excision Needle Localization:  No Laterality: Right Invasive Tumor: Present Multifocality: No WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Tumor size: 2.1cm 1.7cm x 1.5cm Additional dimensions: Tumor Site: . 9:00 Margins:  Negative Distance from closest margin:  0.3cm deep Tubular Score: 3 2 Nuclear Grade: 2 Mitotic Score: 2 Modified Scarff Bloom Richardson Grade: Necrosis: Present Vascular/Lymphatic Invasion:  Present None Lobular neoplasia: Lymph nodes:  Sentinel lymph node only Lymph node status: Positive 1/3 Yes Micrometastases: Non-neoplastic areas: columnar cell change DCIS present Margins uninvolved by DCiS :0.5 cm from the superior margin DCIS Quantity: Estimate 20% DCIS Type: Solid Cribriform DCIS Location: Both associated and separate from invasive tumor mass Nuclear grade: Intermediate Necrosis: Present Location of CA++: Benign epithelium ER/PR/HER2 Results ER: Positive PR: Positive HER2: Pending by FISH pT 2 N 1 Pathoiogical staging (pTN):
+
+--- Page 3 ---
+TSS ID SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimen: Surgical Excision Block Number: ER: Positive Allred Score: 8 = Proportion Score 5 + Intensity Score 3 PR: Positive Allred Score: 6 = Proportion Score 3 + Intensity Score 3 COMMENT:  The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring. range from 0 to 8.. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2. METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours.. Immunohistochemistry was performed using the mouse anti-human ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) provided by  following the manufacturer s instructions. This assay was not modified. interpretation of the ER/rk irnmunohistochemical stain is guided by published. results in the medical literature, information provided by the reagent manufacturer and by internal. review of staining performance. SYNOPTIC REPORT - BREAST HER-2 RESULTS Specimen: Surgical Excision Block Number: Interpretation: EQUIVOCAL Intensity: 2+ % Tumor Staining: 20% Fish Ordered: Yes , on Date METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Her2 analysis was performed using the FDA approved Dako HercepTest (TM) test kit  using rabbit anti-human HER2. This assay was not modified. External kit-slides.  providea oy tne manufacturer (cell lines with high, low and negative HER2 protein expression) and in- house known HER2 amplified control tissue were evaluated along with the test tissue. Adequate, well preserved, clear-cut invasive carcinoma was identified for HER2 evaluation. Interpretation of the HER2 immunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal review of staining performance.. This assay has been validated according to the 2007 joint recommendations and guidelines from ASCO and CAP and from the NCCN HER2 testing in Breast Cancer Task Force. The  takes full responsibility for this test's performance. PRE-OPERATIVE DIAGNOSIS: Right breast cancer.. PRE-OPERTATIVE CONSULTATION: TPA/TPB/TPC: Negative for carcinoma. Diagnosis called to Dr. at. D. Gross Inspection Diagnosis: 2.1 cm tumor at 0.6cm from closest superior margin. Diagnosis called to. Dr.. Dr. at by Dr. ADDENDUM: PathVysion HER-2 DNA Probe Kit Case No Analytical Interpretation of Results: HER-2 NOT AMPLIFIED Clinical Interpretation of results Amplification of the HER-2 gene was evaluated with interphase fluorescence in-situ hybridization (FISH) on formalin-fixed paraffin embedded tissue sections using a chromosome 17 centromeric probe and a HER-2 probe that spans the entire HER-2 gene in the
+
+--- Page 4 ---
+TSS ID ' by Dr.. A majority of tumors cells displayed 2 chromosome 17 signals and 2 HER-2 signals, with a HER-2/CEP 17 Ratio </=2.0, consistent with no amplification of the HER2/neu gene. Block usedD9 Source of case: RPCI formalin-fixed tissue Outside Case No:NA Tissue fixation breast Results interpreted: yes Tissue source HER2/CEP17 ratio: 1.05 This ratio is derived by dividing the total number of LSI HER-2/neu signals by the total number of CEP17 signals in at least 20 interphase nuclei with nonoverlapping nuclei in the neoplastic mammary epithelial cells. Cells with no signals or with signals of only one color are disregarded. Method of ratio enumeration:  manual count Limitations The Vysis PathVysion Kit is not intended for use to screen for or diagnose breast cancer. It is intended to be used as an adjunct to other prognostic factors currently used to predict disease-free and overall survival in stage ll, node-positive breast cancer patients. In making decisions regarding adjuvant CAF treatment, all other available clinical information should also be taken into. consideration, such as tumor size, number of involved lymph nodes, and steroid receptor status. No treatment decision for stage li, node-positive breast cancer patients should be based on HER-. 2/neu gene amplification status alone. Overview of this test FDA APPROVED REAGENT  PathVysion HER-2 DNA Probe Kit is FDA approved for selection of patients fnr whom Herceptin therapy is being considered. These tests were performed in the , , Institute under the direction of. The results of these studies should always be interpreted in the context of the clinical, morphological, and immunophenotypic diagnosis. Gross Dictation:., Pathologist, ' Microscopic/Diagnostic Dictation:, Pathologist, I Finai Review... Pathologist, Final Review.., Pathologist Microscopic/Diagnostic Dictaton:., Pathologist Final Review:, Patholoaist. Final.:., Pathologist, Addendum.., Pathologist. ' Addendum Final:, Pathologist,
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diff --git a/output/text/e54fba3d-4e1a-4ab9-aa58-319756bbf1b4.txt b/output/text/e54fba3d-4e1a-4ab9-aa58-319756bbf1b4.txt
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index 0000000000000000000000000000000000000000..ef89b980385f7118f0919f5d094a52aab5635f2f
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+UUID:838A3E82-E8E4-4A70-ADEE-A1360940EECE D.O.B.: ge: TCGA-AC-A2FM-01A-PR Redacted MRN #: 1  Ref Physician SPECIM Collected Accession #: Received: Acct / Reg #: Reported: SurgicaL patholOgy REPORt DIAGNOSIS. DIAGNOSIS: A. Sentinel lymph nodes x2: Small foci of metastatic carcinoma in the perinodal connective tissue. These foci of metastatic carcinoma are not seen within the node. Sixe: Approximately 0.5 cm. These foci are identified on the H and E stain and confirmed by staining for cytokeratin CAM 5.2 B. Right breast Infitrating mammary carcinoms ze3x3x2.8cm. Architecturaf score: 3/3 Nuclear score: 2/3 Mitotic score: 1/3 Total score: 6/9 -= grade iI. No significant component of in situ carcinoma. Anglo invasion not identified. Ancillary studies were reported on the original needle biopsy and will not be repeated. All surgical margins of excision are free of carcinoma. The closest surgical margin is deep and is approximately 0.2 cm. Electronic Signature: CLJNICAL INFORMATION CLINICAL HISTORY: jcs-0-3 Preoperative Diagnosis: Right broast cancer.: cmnfiirmurg Postoperative Diagnosis: emri  Symptoms/Radiologic Findings: 8 Sq0/3 SPECIMENS: Sip: brestnos c5o.9 p b/10/11 A. Sentinet node.x2 B. Right breest SPECIMENDATA GROSS DESCRIPTION: A. Container A is labeled  nd consists of two tan yellow firm fatty lymph nodes the largest 1.0 x 0.8 x 0.5 cn. Both nodes are sanpled for frozen section and all tissue submitted in two cassettes designated as frozen section tissue as 1; all remaining tissue as 2. B. Container B is labeled  and consists ot a 450 gram portion of right breast tissue, 20 x 15 x 5 crn with attached tan pink ellipse of skin, 18 x 8.  cm disptaying an eccentrically located raised nipple 1.0 cm in greatest dimension. The deep margin of the specimen has been inked and the specimen  serially sectioned to reveal predominantly tan yellow lobular adipose tissue intermixed with a minimal amount of tan gray dense fibrous tissue. A gray.  white dense mass is found near the lateral aspect of the specimen 3 x 3 x 2.8 cm in greatest dirnension which extends from 1 cm below the skin margin up to within 0.1 cm of the deep margin. No other lesions are grossly identified. Sectioning along the lateral margin of the specimen reveals no tymph cassettes. Representative sections are submitted in ten cassettes and are designated as follows: nipple submitted as 1; lesion as 2-5; deep margin 6;  upper inner quadrant 7; upper outer as 8; lower inner 9; lower outer as 10. is 2.5 cm mass found 1 mm fron the. ccp inargin.
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diff --git a/output/text/e57d21db-3e1b-41ce-8d1e-34d8975a9234.txt b/output/text/e57d21db-3e1b-41ce-8d1e-34d8975a9234.txt
new file mode 100644
index 0000000000000000000000000000000000000000..faf4c6c840a9703a7c21646a3806eff7acc37ac6
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+SURGICAL PATHOLOGY REPORT Material Submitted: !eft breast with axillary contents nicol 1cs-0-3 History: Carcioma, mifitnsting ductal, nos. Clinical 8500/3 Diagnosis: Sin: bresst Nos c5o.9 Operating 1/s/n pw Surgeon: Pathology Number Dr. Gross Examination:. The specimen is received in a single container, labeled with the patient's name, history. number, date and "left breast and axillary contents". Received is a breast measuring approximately 23.0 x 16.0 x 8.5 cm. Also received is axillary contents measuring 8.0 cm. x 9.0 cm.x 3.0 cm. There is no previous scars or other lesions on the surface of the breast. Noted grossly was a 5.0 x 5.0x 4.0 cm. mass submitted for receptors. The specimen has been inked in blue and sectioned extensively berore accessioning. Examination of the specimen reveals a firm white nodule measuring approximately 3.5 x 3.0 cm. in two dimensions. Gross inspection of the tumor at the deep margin does not show extension through the deep margin grossly. Representative sections are submitted as follows: Block I: representative section of tumor to show deep margin.. T~V Block II: representative section of tumor to show deep margin.. Bloeks III and IV: representative sections of the tumor.. Palpation of the remainder of the breast does not reveal any separate nodules from the. main tumor region. From the main mass, a couple of satellite nodules are noted that appear to be contiguous with the main mass. A section of this area is submitted in Block v.. Block VI: representative section of nipple. Block VII: representative section of skin over tumor. Block viII: random sample of upper inner quadrant. Block IX: random sample of lower inner quadrant.. Block X: random sample of upper outer quadrant.. Block XI: random sample of lower outer quadrant. The axillary contents are separate from the remainder of the specimen and palpated for. lymph nodes. Lymph node candidates are submitted from the inferior to the superior direction. They are submitted as follows: Block xII: two lymph node candidates. Block Xill: three Iymph node candidates.. Block Xiv: three Iymph node candidates. UUID: 2D3D759B-D06A-4FC6-85SA-SE9F83ADBED9 CGA-B6-A0I6-01A-PI Redacted Block Xv: five lymph node candldates. Block XVI: three lymph node candidates. Block xvi: three lymph node candidates.. Block XviII: five lymph node candidates.. (Continued on
+
+--- Page 2 ---
+Dr rage 2. Dr. (Continuation from page 1). Block Xix: five lymph node candidates. Block Xx: three lymph node candidates. Block xxI: five lymph node candidates. Block Xxil: five lymph node candidates. Block XxI: three lymph node candidates. Block Xxiv: three lymph node candidates. MICROsCOpIC: The apparent satellite nodules seen grossly (Block 5) consist of sclerosis and hemangioma (so-called "peritubular hemangioma"). carcinoma have intermediate grade nuclei, but areas have a high grade nuclear pattern. Portions of the. DIAGNOSIS: #1 "LEFT"| BREAST, MASTECTOMY: A.-LARGE (5.0 x 5.0 x 4.0 CM.) INFILTRATING DUCTAL CARCINOMA, N.S.A.B.P. NUCLEAR GRADE POORLY DIFFERENTIATED, HISTOLOGIC GRADE 3 OF 3. 3. FOCAL INTRATUMORAL INTRADUCTAL CARCINOMA. C. PROMINENT VASCULAR INVASION BY CARCINOMA. D. NO CARCINOMA IDENTIFIED IN SURGICAL MARGINS. E. HEMANGIOMA. F. FIBROCYSTIC CHANGES: 1. MARKED DUCTAL EPITHELIAL HYPERPLASIA. 2. PAPILLARY APOCRINE METAPLASIA. 3. DUCT ECTASIA. 4. SCLEROSIS. #2 "LEFT" AXILLARY DISSECTION: A. METASTATIC CARCINOMA IN 6 OF 32 LYMPH NODES. B. FOCAL CARCINOMA IN PERINODAL BLOOD VESSELS.
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diff --git a/output/text/e583fbf6-5603-4644-9d71-e8c76ae7eaf1.txt b/output/text/e583fbf6-5603-4644-9d71-e8c76ae7eaf1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..71fb955bb9ee9e6d252ec9fa2d21a2140eab581c
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+ Hospital MRN: Surgery ov MD A  UUID: 3E54B0CE-8863-4728-BC95-A47C1869F52A Laboratory Patient Report Redacted TCGA-AC-A2BK-01A-PR Print Date/Time: Surgical'Pathology Histopathological Examination ) Path# Collected:  Received: ; Complete Pre-Op Diagnosis : Left Breastr Ca. /co-0-3 Order~ Physician MD Specimens Breast, left Frozen Diagnosis. Situ : bresot Nos c50.9 hJ 5fo7|u Report : GROSS EXAMINATION: The specimen is received in a container labeled with the name of the patient and labeled as breast, left. The specimen consists of a mastectomy designated left which measures en bloc 31 x 20 x 5.5 cm and weighs 1515 g. Anteriorly located is an ellipse of brown skin which. measures 22 x 17 cm.  Centrally located is a 4.5 cm diameter areolar complex with slightly retracted nipple which is. sampled in block 1. The~deep margin is inked and the. specimen is serially sectioned and shows a gray-tan firm. 2.5 x 2.3 cm and grossly extends to within 1 cm of the inked. deep margin. A section'of skin overlying the mass is. submitted in block 2. A section of the Inked deep margin is submitted in block 3. Sections of the mass are submitted in block 4-7.  The remaining breast is composed of yellow. 1obulated adipose tissue admixed with islands of gray-white. rubbery tissue..  The breast is divided into four quadrants;. upper lnner, lower inner, upper outer and lower outer and. sampled in blocks 8-11. 'The attached axillary tissue is dissected for lymph nodes with the lower part sampled in. blocks 12-i4 in'the upper part sampled in blocks 15-16. DIAGNOSIS BASED ON GROSS AND MICROSCOPIC EXAMINATION: Specimen Type: Modified radical mastectomy. LYMPH NODE SAMPLING: Axillary dissection. LATERALITY: Left TUMoR sITE: Upper outer. quadrant SIZE OF INVAsIVE COMPONENT: Greatest dimension ADDITIONAL DIMENSIONS:. 2.8 /cm. 2.5 cm HISTOLOGIC TypE: Lavasive ductalcarcinana. THIS CONFIDENTIAL AND PRIVILEGED DOCUMENT/INFORMATION IS PROTECTED BY FEDERAL AND STATE LAW. UNAUTHORIZED DISCLOSURE, DISSEMINATION OR_DUPLICATION IS PROHIBITED Path #: Visit Page 1 MR#: of 2 # :
+
+--- Page 2 ---
+HISTOLOGIC GRADE: Nottingham histciogic score 3/3  Not identified. DUCT IN SITU COMPONENT: .MICROCALCIFICATIONS: Not identified. EXTENT OF INVASION PRIMARy TUMOR (PT): pT2: Tumor more than 2.0 cm but not more than 5.0 cm in greatest dimension.. REGIONAL LYMPH NODES (PN): pN2a: Metastases in 4 to 9 axillary lymph nodes. NUMBER EXAMINED: 23 NUMBER INVOLVED: 6 DISTANT METASTASIS (PM) : PMX MARgins: Uninvolved by invasive carcinoma. DISTANCE TO NEAREST MARGIN: 1.0 cm to deep margin. VENOUS/LYMPHATIC (LARGE/SMALL VESSEL) INVASION (V/L) : Present. Summary of pathologic staging: pr2n2amxg3. Intradepartmental consultation obtained. cOmmenr: Immunohistochemical stains for estrogen and progesterone receptors and HeR2 are pending and will be supplementally reported when complete.. M.D. Pathologist Electronically Signed by: MD THIS CONFIDENTIAL AND PRIVILEGED DOCUMENT/INFORMATION IS PROTECTED BY UNAUTHORIZED'DISCLOSURE, DISSEMINATION FEDERAL AND.STATE LAW. OR DUPLICATION IS PROHIBITED Page 2 of 2 Path #: Visit # : MR# :
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diff --git a/output/text/e625ed31-fc15-4529-b0a5-2aebf3d3b246.txt b/output/text/e625ed31-fc15-4529-b0a5-2aebf3d3b246.txt
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index 0000000000000000000000000000000000000000..c97c8fbf47ca7b8b303e61d86c7bc70a5304800e
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+PAGE1 PATIENT: AGE/SEX REG DR Path#: Copies to: Submit Dr: This is a corrected report. Any previous versions are stored internally and are available if necessary. SPECIMEN ID: A. SkIn-Upper lip margin, clip superior. Skin., B. SKIN Inferior margin clip superior, Skin., C. SKIN - Inferior lateral margin, clip superior, Skin,. D. SKIN Lower lip margin, clip superior, skin, E. SKIN mental margin clip superior, skin, F. skin upper cheek margin, skin, G. SKIN Nasolabial margin, skin, clip posterior, H. SOFT TIssuES OF HEAD AND NECK -Right lower alveolar ridge., I. SOFT TIssuEs OF HEAD AND NECK =Right lower gingival labial mucosa margin. J. LIP, NOS lower lip margin, clip at oral comminsure., K. LIP, NOS - upper lip mucosal margin, L. SOFT TISsUES OF HEAD AND NECK-Anterior Buccal margin clip anterior, M. SOFT TISSUES OF HEADAND NECK Posterior Buccal Margin Clip Poterior, N. SOFT TISsUES OF HEAD AND NECK-Retromolar trigone, O. SOFT TIssuES OF HEAD AND NECK-Retromandibular mucosal margin, P. ADIposE TIssuE -posterior buccal fat, 0. SOFT TIssuEs OF HEAD AND NECK - Lower right mandible periosteal margin, R. SOFT TISSUE BUCCAL RESECTION,BUCCAL MUCOSA AND CHEEK SKIN,LOWER LIP S. SOFT TISSUE RIGHT BUCCAL FAT PAD,TNECK,NOS -LEFT NECK DISSECTION LEVEL IB, U. NECK, NOSLEFTNECK DISSECTION LEVELS 2A, V. NECK, NOS RIGHT NECK DISSECTION LEVEL2B W. NECK, OS RIGHT NECK DISSECTION LEVELS 1A,1B,2A34, X. SOFT TISSUE -LEFT FOREARM SUBCUTANEOUS MASS, Y. THYROID GLAND - Right thyroid Iobewith ishmus This report is privileged, confidential and exempt from disclosure under applicable law. If you receive this report inadvertently,please call and return the report to us by mail.
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+PAGE2 SPEC# (Continued) SPECIMEN ID: (Continued) Signed by: (Corrected Result) Edited By: Edit Date: Edit Reason: DIAGNOSIS EDIT/CLARIFICATION A. UPPER LIP MARGIN,CLIP SUPERIOR, SKIN: Skin, no malignancy seen. B. INFERIOR MARGIN, CLIP SUPERIOR,SKIN: Skin, no malignancy seen. C. INFERIOR LATERAL MARGIN,CLIP SUPERIOR,SKIN: Skin, no malignancy seen. D. LOWER LIP MARGIN,CLIP SUPERIOR,SKIN Skin, no malignancy seen. E. MENTAL MARGIN, CLIP SUPERIOR,SKIN: Skin, no malignancy seen. F. UPPER CHEEK MARGIN, SKIN: Skin, no malignancy seen. This report is privileged, confidential and exempt from disclosure under applicable law. If you receive this report inadvertently,please call and return the report to us by mail.
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+--- Page 3 ---
+PAGE3 SPEC# (Continued *** FINAL DIAGNOSIS *** (Continued) (Corrected Result) NASOLABIAL MARGIN,SKIN, CLIP POSTERIOR: Skin, no malignancy seen. H. RIGHT LOWER ALVEOLAR RIDGE: No malignancy seen. I. RIGHT LOWER GINGIVAL LABIALMUCOSA MARGIN: No malignancy seen. J. LOWER LIP MARGIN,CLIPATORAL COMMISSURE: No malignancy seen. K. UPPER LIPMUCOSAL MARGIN: No malignancy seen. I. ANTERIOR BUCCAL MARGIN, CLIP ANTERIOR: No malignancy seen. M. POSTERIOR BUCCAL MARGIN,CLIPPOSTERIOR: No malignancy seen. N. RETROMOLAR TRIGONE: No malignancy seen. This report is privileged, confidential and exempt from disclosure under applicable law. If you receive this report inadvertently,please call and return the report to us by mail.
+
+--- Page 4 ---
+PAGE4 SPEC# (Continued) ** FINAL DIAGNOSIS *** (Continued) (Corrected Result) O. RETROMANDIBULAR MUCOSALMARGIN: No malignancy seen. P. POSTERIOR BUCCAL FAT: No malignancy seen. Q. LOWER RIGHT MANDIBLE PERIOSTEAL MARGIN: No malignancy seen. R. BUCCAL RESECTION, BUCCAL MUCOSA AND CHEEK SKIN, LOWER LIP This case was reviewed and discussed at the weekly. Inmy opinion, the buccal mucosa carcinoma is best characterized as a low to intermediate grade mucoepidermoid carcinoma. The case was discussed with Tumor size 2.0 cm by microscopic estimate). No perineural or lymphovascular invasion seen. Margins negative for tumor (see frozen section A through Q above). S. RIGHT BUCCAL FAT PAD: Benign adipose tissue and salivary gland tissue. No evidence of malignancy. T. LEFT NECK DISSECTION,LEVEL1B: This report is privileged, confidential and exempt from disclosure plicable law. If you receive this report inadvertently, please call and return the report to us by mail.
+
+--- Page 5 ---
+PAGE5 SPEC# (Continued) *** FINALDIAGNOSIS *** (Continued) (Corrected Result) Lymph nodes (2; negative for tumor Benign salivary gland tissue; negative for tumor. U. LEFT NECK DISSECTION LEVELS 2A Lymph nodes (17); negative for tumor. V. RIGHT NECK DISSECTION LEVEL 2B: Lymph nodes (4); negative for tumor. W. RIGHTNECK DISSECTION LEVELS1A,1B2A,34: Lymph nodes (25);negative for tumor. Salivary gland tissue; no evidence of malignancy. X LEFT FOREARM SUBCUTANEOUS MASS: Angiolipoma. Y. RIGHT THYROID LOBE WITH ISTHMUS: Multiple follicular colloid nodules consistent with goiter with focal chronic inflammation. No evidence of malignancy This report is privileged, confidential and exempt from disclosure under applicable law. If you receive this report inadvertently, please call and return the report to us by mail.
+
+--- Page 6 ---
+PAGE6 SPEC# (Continued) *** FINAL DIAGNOSIS *** (Continued) (Corrected Result) Signed by: MARGIN, CLIP SUPERIOR, SKIN: Skin, no malignancy seen. B. INFERIOR MARGIN,CLIP SUPERIOR,SKIN: Skin, no malignancy seen. C. INFERIOR LATERAL MARGIN, CLIP SUPERIOR,SKIN: Skin, no malignancy seen. D. LOWER LIP MARGIN,CLIP SUPERIOR,SKIN: Skin, no malignancy seen. E. MENTAL MARGINCLIPSUPERIOR,SKIN: Skin, no malignancy seen. E. UPPER CHEEK MARGINSKIN: Skin, no malignancy seen. G. NASOLABIALMARGIN,SKIN,CLIPPOSTERIOR: Skin, no malignancy seen. H. RIGHTLOWER ALVEOLAR RIDGE: This report is privileged,confidential and exempt from disclosure under applicable law. If you receive this report inadvertently, please call and return the report to us by mail.
+
+--- Page 7 ---
+PAGE7 SPEC# (Continued) *** FINAL DIAGNOSIS *** (Continued) No malignancy seen. I. RIGHT LOWER GINGIVALLABIAL MUCOSAMARGIN: No malignancy seen. J. LOWER LIPMARGIN,CLIP AT ORAL COMMISSURE: No malignancy seen. K. UPPER LIP MUCOSAL MARGIN: No malignancy seen. L. ANTERIOR BUCCAL MARGIN,CLIP ANTERIOR: No malignancy seen. M. POSTERIOR BUCCAL MARGIN,CLIP POSTERIOR: No malignancy seen. N. RETROMOLAR TRIGONE: No malignancy seen. O. RETROMANDIBULAR MUCOSAL MARGIN: No malignancy seen. This report is privileged, confidential and exempt from disclosure under applicable law. If you receive this report inadvertently, please call and return the report to us by mail.
+
+--- Page 8 ---
+PAGE8 SPEC# (Continued) *** FINAL DIAGNOSIS *** (Continued) P. POSTERIOR BUCCAL FAT: No malignancyseen. Q. LOWER RIGHT MANDIBLE PERIOSTEAL MARGIN: No malignancy seen. R. BUCCAL RESECTION, BUCCAL MUCOSA AND CHEEK SKIN,LOWER LIP: Invasive well differentiated squamous cell carcinoma. Tumor size 2.0 cm(by microscopic estimate) No perineural or lymphovascular invasion seen. Margins negative for tumor (see frozen section A through Q above). RIGHT BUCCAL FAT PAD: Benign adipose tissue and salivary gland tissue. No evidence of malignancy. T. LEFT NECK DISSECTION,LEVEL1B Lymph nodes (2); negative for tumor. Benign salivary gland tissue; negative for tumor. U. LEET NECK DISSECTION LEVELS2A: Lymph nodes(17);negativefortumor. This report is privileged, confidential and exempt from disclosure under applicable law. If you receive this report inadvertently,please call and return the report to us by mail.
+
+--- Page 9 ---
+PAGE 9 SPEC # (Continued) *** FINAL DIAGNOSIS *** (Continued) V. RIGHT NECK DISSECTION LEVEL 2B Lymph nodes (4); negative for tumor. W. RIGHT NECK DISSECTION LEVELS1A1B2A34 Lymph nodes (25)negative for tumor Salivary gland tissue; no evidence of malignancy. X. LEFTFOREARM SUBCUTANEOUS MASS: Angiolipoma. Y. RIGHT THYROID LOBE WITH ISTHMUS: Multiple follicular colloid nodules consistent with goiter with focal chronic inflammation. No evidence of malignancy. This report is privileged,  confidential and exempt from disclosure under applicable law. If you receive this report inadvertently, please call and return the report to us by mail.
+
+--- Page 10 ---
+PAGE10 SPEC# (Continued) CLINICAL HISTORY- PRE-OPDX Not provided PROCEDURE: Notprovided RELEVANT CLINICALHX:Not proVided GROSS DESCRIPTION: A. Received fresh and labeled "Upper lip margin clip superior (skin)" is a soft tissue fragment which measures 1.4 x 0.3 x 0.1 cm. Clip margin inkedin blue.Specimen submitted in toto in one cassette for frozen section. B. Received fresh and labeled "Inferior margin clip superior (skin)" is a soft tissue fragment measuring 0.5 x 0.3 x 0.2 cm. Clip margin inked in blue. Specimen submitted in toto in one cassette for frozen section. C. Received fresh and labeled "Inferior lateral margin clip superior (skin)" is a soft tissue fragment which measures 1.3 x 0.5 x 0.2 cm. Clip margin inked in blue. Submitted in toto in one cassette for frozen section. D. Received fresh and labeled "Lower lip margin clip superior (skin)" is a soft tissue fragment which measures 1.3 x 0.3 x 0.2 cm. Clip margin inked in blue. Submitted in toto in one cassette for frozen section. E. Received fresh and labeled "Mental margin clip superior (skin)" is a soft tissue fragment which measures 1.0x O.7 x O.2 cm.Clip marginis inked in blue. Submitted in toto in one cassette for frozen section. E. Received fresh and labeled "Upper cheek margin (skin)" is a soft tissue fragment which measures 1.3 x 0.3 x 0.2 cm. Clip margin inked in blue. Submitted in toto for frozen section in one cassette. G. Received fresh and labeled "Nasolabial margin (skin) clip posterior" is a.soft tissue fragment which measures 1.5 x 0.3 x 0.2 cm. Clip margin inked in blue. Submitted in toto in one cassette for frozen section. H. Received fresh and labeled "Right lower alveolar ridge" is a soft tissue fragment measuring 2.0x0.3x0.2 cm. Submitted in toto in one cassette for frozen section. I. Received fresh and labeled "Right lower gingival labial mucosa margin" is a soft tissue fragment which measures 1.2 x 0.7 x 0.2 cm. Submitted in toto in one cassette This report is privileged, confidential and exempt from disclos sure under licable law. If you receive this report inadvertently,please call and return the report to us by mail.
+
+--- Page 11 ---
+PAGE11 SPEC# (Continued) GROSS DESCRIPTION: (Continued) for frozen section. J. Received fresh and labeled "Lower lip margin clip at oral commissure" is a soft tissue measuring 1.3 x 0.3 x 0.2 cm.Clip margin inked in blue.Submitted in totoin one cassette for frozen section. K. Received fresh and labeled "upper lip mucosal margin" is a soft tissue fragment which measures 1.2 x 0.5 x 0.2 cm. Submitted in toto in one cassette for frozen section. L. Received fresh and labeled "Anterior buccal margin clip anterior" is a soft tissue fragment measuring 1.3 x O.6 x 0.3 cm. Clip margin is inked in blue. Submitted in toto in one cassette for frozen section. M. Received fresh and labeled "posterior buccal margin clip posterior" is a soft tissue fragment measuring 1.5 x0.5 x 0.3 cm. Clip margin inked in blue. Submitted in toto in one cassette for frozen section. N. Received fresh and labeled "Retromolar trigone is a soft tissue fragment which measures 1.1 x 1.0 x 0.3 cm. Submitted in toto in one cassette for frozen section. O. Received fresh and labeled "Retromandibular mucosa margin" is a soft tissue fragment which measures 1.0 x 0.3 x 0.2 cm. Submitted in toto in one cassette for frozen section. P. Received fresh and labeled "Posterior buccal fat" is a fibroadipose tissue which measures 2.5 x 1.5 x 0.4 cm. Representative section submitted for frozen and no lesions grossly identified. Sections submitted as follows: Cassette #1Fs:Frozen section Cassette #1: Remaining tissue submitted in toto Q. Received fresh and labeled "Lower right mandible periosteal margin" is a soft tissue fragment which measures O.9 x O.1 x O.1 cm. Submitted in toto in one cassette for frozen section. R. Received in formalin and labeled "Buccal resection, buccal mucosa and cheek skin, lower lip, mental skin suture superior" is a specimen with skin mucosa and fibroadipose tissue which measures 5.5 x 5.0 x 3.0 cm. The skin measures 4.0x 3.0x 0.1 cm.A surgical scar on the skin surface measures 2.0 cm in length x 0.1 x 0.1 cm. The mucosa measures 5.0 x 3.0 x 0.1 cm. The external surface of the mucosa is nodular with small focal ulceration which is less than O.1 cm. Specimen is inked as follows: This report is privileged, confidential and exempt from disclosure under applicable law. If you receive this report.inadvertently, please call and return the report to us by mail.
+
+--- Page 12 ---
+PAGE12 SPEC# (Continued) GROSS DESCRIPTION: (Continued) superior, blue; inferior, green; anterior, red; posterior, black. Sectioning reveals a poorly defined nodular tumor which is tan to white. Tumor appears 0.5 cm from the anterior margin, 1.0 cm from posterior margin, less than O.1 cm from the inferior margin, 1.0 cm from the superior margin. The tumor extends to the mucosal margin. It is 1.0 cm from skin.The tumor measures 2.5 x 2.5 x 3.0 cm. Sections submitted as follows: Cassette #l: Anterior margin, two fragments Cassette #2: Posterior margin, two fragments Cassette #3: Inferior margin Cassette #4: Superior margin Cassette #5: Tumor in relation to mucosal margin and ulcerated area and also shows relationship of tumor to skin Cassettes #6&7: Composite section of tumor with surrounding fat Cassettes #8&9: Composite section of tumor Cassette #10: Representative section of brown area extending from tumor S. Received in formalin and labeled "Right buccal fat pad" are multiple fragments of adipose tissue which measures 4.0 x 2.0 x 1.0 cm in aggregate. No lesions grossly identified. No lymph nodes. Specimen submitted in toto in cassettes #1-4. T. Received in formalin and labeled "Left neck dissection level 1B" is a fibroadipose tissue which measures 5.0 x 4.0 x 2.5 cm. Salivary gland is present which measures 4.6 x2.5 x 2.0 cm.Largest 1ymph node measures 2.3 x 0.5 x 0.5 cm.Sections submitted as follows: Cassette #1: Largest lymph node bisected Cassette #2: Two possible 1ymph nodes Cassette #3: Representative section of salivary gland U. Received in formalin and labeled "Left neck dissection level 2A" is a fibroadipose tissue which measures 6.0 x 4.0 x 2.5 cm.Largest lymph node measures 2.0x 1.0x 0.5 cm. Sections submitted as follows: Cassette#1: Fourlymph nodes Cassette #2 Four possible lymph nodes Cassette #3 Four I possible lymph nodes Cassette #4 Four possible lymph nodes Cassette #5: One lymph node bisected Cassette #6 One lymph node bisected Cassette#7 One lymph node bisected This report is privileged, confidential and exempt from disclosure under applicable law. If you receive this report inadvertently, please call and return the report to us by mail.
+
+--- Page 13 ---
+PAGE 13 SPEC# (Continued) GROSS DESCRIPTION: (Continued) Cassette #8: One 1ymph node V. Received in formalin and labeled "Right neck dissection level 2B" is a fibroadipose tissue which measures 3.5 x1.0 x 1.0 cm. Largest 1ymph node measures 0.6 x 0.5 x 0.3 cm. Sections submitted as follows: Cassette #1: One lymph node Cassette #2: Remainder of fibroadipose tissue in toto W. Receivedin formalin and labeled "Right neck dissection levels 1A, 1B, 2A, 3, 4 isa fibroadipose tissue which measures 8.0 x 5.5 x 4.0 cm. Specimen is unoriented. Salivary gland is identified which measures 4.5 x 2.5 x 2.0 cm. Largest lymph node measures1.7x1.0 x0.6 cm.Sections submitted as follows: Cassette #1: Largest lymph node bisected Cassette #2: One 1ymph node bisected Cassette#3 One lymph node bisected Cassette#4: One lymph node bisected Cassette #5: One lymph node bisected Cassette:#6: Six possible lymph nodes Cassette #7: Six possible 1ymph nodes Cassette #8: Five possible lymph nodes Cassette #9: Six possible 1ymph nodes Cassette #10: One lymph node bisected and representative section of salivary gland X. Received in formalin and labeled "Left forearm subcutaneous mass" are small fragments of pale tan/white tissue which measures 1.5 x 1.3 x l.0 cm in aggregate. Submitted in toto in one cassette Received fresh and labeled "Right thyroid lobe with isthmus" is a right thyroid lobe with isthrnus.Specimen weighs 13.82 grams and measures 4.3 x2.5 x2.5 cm.Isthmus measures 1.0 x 0.5 x 0.5 cm. External surfaceis smooth and has no lesions It is inked in black. There is a nodule in the right lobe which extends from the superior pole through the mid pole which is well circumscribed and measures 3.0 x2.5 x 2.0 cm. It is yellow and colloid in appearance. There is a small nodule in the isthmus which measures 1.0 x 0.5 x 1.0 cm. It is yellow and well circumscribed.Representative section of large nodule submitted for frozen section. Isthmus margin submitted for frozen section. Remainder of specimen is placed in formalin for permanent. There are some calcifications in the nodule. Remainder of thyroid gland is beefy red brown and unremarkable. Thyroid submitted in toto. Sections submitted as follows: This report is privileged, confidential and exempt from disclosure under applicable law. If you receive this report inadvertently please call and return the report to us by mail.
+
+--- Page 14 ---
+PAGE14 SPEC# (Continued) GROSS DESCRIPTION: (Continued) Cassette#lFs:Margin at isthmus Cassette #2rs: Representative section of nodule Cassettes #1-3:Nodule in superior pole ofright lobe Cassettes #4-7: Nodule in middle pole right lobe Cassettes #8&9: Nodule in normal thyroid gland tissue and inferior pole right lobe. Cassettes #10&ll: Isthmus with nodule in toto Cassette #11: Two Iymph nodes submitted with isthmus OPERATING ROOM CONSULT A) Upper lip margin, clip superior, Skin. Skin. no malignancy Seen. B) Inferior margin, clip superior, Skin. Same as A. C) Inferior lateral margin, clip Superior, Skin. Same as A. D) Lower lip margin, clip superior, Skin. Same as A. E) Mental Margin, clip superior, Skin. Sameas A. F) Upper cheek margin, Skin Same as A. G Naso Labial margin, Skin, Clip Posterior. Same as A. H) Right lower alveolar ridge. No malignancy seen. I) Right lower gingival labial mucosa margin. Same as H) J) Lower lip margin. Clip at oral commisure Same asH) K) Upper lip mucosal margin. Same as H. L) Anterior buccal margin. clip anterior. Same as H M) Posterior Buccal Margin. Clip Posterior. Same as H) Retromolar trigone. N This report is privileged, confidential and exempt from disclosure under applicable law. If you receive this report inadvertently,please call and return the report to us by mail.
+
+--- Page 15 ---
+PAGE15 SPEC# (Continued) OPERATING ROOM CONSULT (Continued) Same as H) O) Retromandibular mucosal margin. Same as H) P) Posterior Buccal Fat. Same asH Q) Lower right mandible periosteal margin. Same as H) Y)Right thyroid lobe with ishmus. Representative section: -Follicular lesion. -Defer final diagnosis forcomplete sampling and permanent sections.. This report is privileged, confidential and exempt from disclosure under applicable law. If you receive this report inadvertently, please call and return the report to us by mail
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diff --git a/output/text/e66edf1d-8d56-4400-b25d-cdc0eaf6cd9e.txt b/output/text/e66edf1d-8d56-4400-b25d-cdc0eaf6cd9e.txt
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index 0000000000000000000000000000000000000000..f054422d0fc3d2456dc64e1aa8f6a58dcf9a8d3c
--- /dev/null
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@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+! Specimen Clinical  Clinical DOB  Date of Ethnicity Index Case # Site # Sex (Race) 'procuremen! label : Diagnosis : (mm/dd/yyyy) Colorectal cancer Colorectal cancer
+
+--- Page 2 ---
+Tissue . Anatomical !  Tumor Specimen Specimen : Number of ' Amount/per! Unit I Specificatio I Matrix  Container I Site Location Format I containers : container : n Colon,  Primary Tumor Tissue Frozen cryomold 1 390 mg sigmoid  Blood n/a  normal  Blood Frozen tube 1 4 ml
+
+--- Page 3 ---
+ Prior Type of Chemo/ Histological ! TNM Stage : I TNM Stage : : TNM Stage ! Chemo / Prior 'Procuremen! Grade Horm Th description (T) (N) (m) : Hormonal Radiation Details Th  Surgery Adenocarcinoma no data 3 0 X no no no  Blood draw n/a n/a n/a n/a n/a no  no no
+
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+Cellular  Tumor % 70 n/a
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index 0000000000000000000000000000000000000000..2f19e85c2ff4700282bee4bbb807511bb2e7a256
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+Diagnosis: Resected colon with a moderately differentiated adenocarcinoma of colorectal type. measuring max 3.5cm with infiltration to the tunica muscularis propria. Tumor-free lymph nodes in this region. Tumor-free colonic resection margins. Tumor-free mesenteric resection margin. Tumor stage therefore pT2, pN0 (0/21) pMX; G2, L0, V0, R0
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diff --git a/output/text/e6ac07e0-2013-4551-90e6-ee23eb7c9924.txt b/output/text/e6ac07e0-2013-4551-90e6-ee23eb7c9924.txt
new file mode 100644
index 0000000000000000000000000000000000000000..cf3f65bb7937bf674a8ae60be2e8f5f0d1a9e717
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:6758673 9CF-41BF-8405-090C21EBCECF TCGA-Y8-A8RY-01A-PR Redacted KD63 Research Gross Description 8Q60L3 male with multiple left kidney lesions Dt  eAni Nos 064.9 Research Dx 11/17/14 Left kidney, laparoscopic nephrectomy: Papillary renal cell carcinoma. CASE SUMMARY FOR NEPHRECTOMY FOR RENAL CELL CARCINOMA: Procedure: Laparoscopic nephrectomy Specimen laterality: Left Tumor site: Left kidney, central and superior Tumor size: 4.5 by 4 x 4 cm (central) and 0.8 cm (superior) Extent of disease: Limited to the kidney Histologic type: Papillary renal cell carcinoma, type 1 Sarcomatoid features: Not identified Tumor necrosis: Not identified Histologic grade (Fuhrman Nuclear Grade): 2 Margins: Negative for carcinoma Lymphovascular invasion: Not identified Pathologic staging (pTNM): Primary tumor: pT1b: Tumor more than 4 cm but less than 7 cm in greatest dimension, limited to the kidney Regional lymph nodes: pNx: Unable to assess Distant metastasis: pM: Not applicable Pathologic findings in nonneoplastic kidney: None identified Other tumors and/or tumor-like lesions: Papillary adenomata. Benign renal cyst.. AJCC Staging (7th edition) pT1b pNX pM: Not applicable COMMENT Research QC Tumor: 99% tumor nuclei 0% necrosis 1% normal Normal: 100% kidney Research Specimen Specimen Process Time Blood draw time: Plasma frozen time: Serum frozen time: Buffy coat frozen time: Cold ischemia start time
+
+--- Page 2 ---
+Formalin fixation start time: Total cold ischemia time. Formalin fixation stopped time Total formalin fixation time: Specimen Weight. T1- 138mg, T2- mg, T3- mg, T4- mg N1-191mg, N2- mg, N3- mg, N4- mg Specimen Size Plasma x 2 Serum x 2 Buffy coat x 1 Cryovials x 8 Normal x 4 Tumor x 4 Metastatic x 0. FFPE x 8 Normal x 4 Tumor x 4 Metastatic x 0 Study Patient Consent Yes M
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diff --git a/output/text/e6cdca85-a344-4fbf-bad9-32f385c23571.txt b/output/text/e6cdca85-a344-4fbf-bad9-32f385c23571.txt
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index 0000000000000000000000000000000000000000..047cc773e1b3e134e962c44ef2caad0625a1118a
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+1cd-0 -3 Carinoma, mfilt^sting duct, NOS 8500[3 128/10 lu Pasth CQcF Site: hresst, N09 c50.9 TSS: UUID:750D4149-BD70-4D7C-8915-9694BD1EC760 SPECIMENS: Redacted A. SLN #1 B. LEFT BREAST EXCISION C. ADDITIONAL MARGIN MEDIAL, ANTERIOR, POSTERIOR SPECIMEN(S): A. SLN #1 B. LEFT BREAST EXCISION C. ADDITIONAL MARGIN MEDIAL, ANTERIOR, POSTERIOR INTRAOPERATIVE CONSULTATION DIAGNOSIS: TPA-SLN #1: Negative for tumor called by Dr to Dr at . B: Gross only, tumor 0.1 cm from medial margin called by Dr. to Dr. at GROSS DESCRIPTION: A. SLN #1 Received fresh is a 3.5 x 1.1 x 0.4 cm piece of soft tissue containing a lymph node. A touch prep is performed; lymph node is submitted in cassette A1. B. LEFT BREAST  Received fresh labeled with the patient's identification and "left breast" is an oriented (single-anterior, double-lateral) 43 g, 4.1 x 3.2 x 3 cm lumpectomy without radiograph. The specimen has been inked in OR per protocol: Anterior- yellow, posterior-black, medial-green, lateral-red, superior-blue, inferior-orange. Specimen is serially sectioned from lateral to medial into 6 slices revealing a 1.9 x 1.4 x 1.3 cm firm tan circumscribed mass that is closest to the medial margin at less than 0.2 cm. Tissue is procured. Representatively submitted.. B1: iateral margin, perpendicular sections B2: slice 3, mid posterior, mass B3: slice 3, posterior inferior, mass B4: slice 4, lower anterior, mass B5: slice 5, superior anterior B6: slice 5, superior posterior B7: slice 5, mid anterior B8: slice 5, mid posterior, mass B9: slice 5, inferior anterior B10: slice 5, inferior posterior  B11-B12: medial margin, perpendicular sections C. ADDITIONAL MEDIAL, ANTERIOR-POSTERIOR MARGIN  Received fresh labeled with the patient's identification and "additional mediai, anterior-posterior margin" is an oriented (suture at final margin) 7 g, 0.7 x 3.2 x 0.9 cm fibrofatty tissue. Final margin is inked black. Seria!. sectioning reveals no discrete lesions. Entirely submitted in cassettes C1-C5.. DIAGNOSIS: A. LYMPH NODES, SENTINEL #1 left axilla, excision:  - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1). B. BREAST, LEFT, WIDE LOCAL EXCISION: - INVASIVE ductaI CARCINOMA, SBR GRADE 3, MEASURING 1.6-CM  - Tumor present 2-mm from inferior surgical margin (closest margin) -biopsy site changes with fibrosis - SEE SYNOPTIC REPORT C. BREAST, ADDITIONAL MEDIAL ANTERIOR POSTERIOR MARGIN, EXCISION: - BREAST TISSUE, NO TUMOR SEEN. SYNOPTIC REPORT - BREAST Specimen Type: Excision Needie Localization: No Laterality: Left Invasive Tumor: Present Multifocality: No  WHO CLASSIFICATION
+
+--- Page 2 ---
+ Invasive ductal carcinoma, NOS 8500/3 Tumor size: 1.6cm Tumor Site: Upper outer quadrant Margins:  Negative Distance from closest margin: 0.2cm inferior Tubular Score: 3 Nuclear Grade: 2 Mitotic Score: 3 Modified Scarff Bloom Richardson Grade:. 3 Necrosis: Absent Vascular/Lymphatic Invasion: None identified Lobular neoplasia:  None Lymph nodes: Sentinet lymph node only. Lymph node status: Negative 0/1 DCIS not present ER/PR/HER2 Results ER: Positive PR: Positive HER2: Negative by IHC Performed on Case: Pathological staging (pTN): pT 1c N 0 CLInICAl HIStOry: Left breast infiltrating cancer upper outer quadrant PRE-OPERATIVE DIAGNOSIS: Left breast cancer Gross Dictation: Pathologist, Microscopic/Diagnostic Dictation: Final Review: Pathologist. Final: Pathologist,
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index 0000000000000000000000000000000000000000..7a9193eccf68ce7dbde7294436b4c34c96e3fbe6
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+
+--- Page 1 ---
+UUID:E1A92F92-1DD2-4E33-9C16-3FD0371D143 TCGA-AR-A0TP-01A-PR Redacted 1CO -0 - 3 cavciioma mifi/trutrg duct, Nos 85oof3 Situ: brsst, Nos c50.9 Breast, left, wide local excision: Infiltrating ductal carcinoma, Nottingham grade IlI (of Ill) forming a 3 x 3 x 2.5 cm mass. Less than 10% of the tumor is in situ. No vascular invasion is identified. (AJCC pT2) The margins of excision are free of tumor. Lymph nodes, left axillary sentinel No.1 and No.2, excision: Multiple (2) left axillary sentinel lymph  nodes are negative for tumor, and contain no blue dye. Cytokeratin immunostains performed on both sentinel lymph nodes confirm the H&E impression (AJCC pN0(i-). Lymph nodes, left axillary, excision: Multiple (3) left axillary lymph nodes are negative for tumor.
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diff --git a/output/text/e6db8dc7-7d20-4002-81ae-b27742c53408.txt b/output/text/e6db8dc7-7d20-4002-81ae-b27742c53408.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e2ebcad6ddf0ee1e0da2b1594c30af1aaff9c2c1
--- /dev/null
+++ b/output/text/e6db8dc7-7d20-4002-81ae-b27742c53408.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+TCGA-A6-2677 SPECIMEN Right colon tissure procurement CLINICAL NOTES GROSS DESCRIPTION Received fresh for tissue procurement labeled "right colon" is a previously-unopened 30 cm segment of proximal right colon with attached 21 cm of distal ileum surfaced by smooth scabrous tan-pink serosa with a moderate amount of attached mesentery, mesocolon, and unremarkable omentum. An unremarkable 3.4 cm appendix averaging 0.5 cm in diameter is present. The proximal and distal margins measure 3 and 5.5 cm in circumference, respectively. On opening, there is a well-circumscribed, 5 x 4.4 cm rubbery white-pink tumor mass involving and extending distal to the ileocecal valve. A portion is submitted for tissue procurement, as requested. On sectioning, the tumor is a maximal thickness of 0.6 cm, grossly extending into the muscularis to within 0.1 cm of the inked-free radial surface. The ileal and remaining colonic mucosa is unremarkable glistening tan-pink with regular folds and the walls average 0.5 cm in thickness. Multiple soft to slightly rubbery tan-pink to tan-white tissues, in keeping with lymph nodes, measuring up to 2.4 cm in greatest dimension are recovered from the attached mesocolon and mesentery. The cut surfaces of the two largest lymph nodes are tan-white, in keeping with metastasis. Representative sections are submitted in 17 blocks, a labeled. RS-17. BLOCK SUMMARY:  1 - Proximal and distal margin, 2 - tumor full-thickness to closest inked-free radial serosal surface, 3 and  additional sections of tumor, including tumor to normal mucosa, 5 - tumor IcB, 6 - random ileum, 7 and 8 - random colon, 9 -- appendix, 10 and 11 - eight whole lymph nodes per cassette, 12 and 13 - seven
+
+--- Page 2 ---
+GROSS DESCRIPTION whole lymph nodes per cassette, 14 and 15 - one bisected lymph node per cassette, 16 and 17 - representative sections from two largest, grossly positive lymph nodes (one lymph node represented per MICROSCOPIC DESCRIPTION Histologic type: Adenocarcinoma. Histologic grade:. Moderately differentiated.. Primary tumor (pT): Primary tumor extends through muscularis propria (pT3).. Proximal margin: Uninvolved.. Distal margin: Uninvolved.. Circumferential (radial) margin: Uninvolved. Vascular invasion: Not identified. Regional lymph nodes (pN): Metastatic adenocarcinoma is present in five of thirty lymph nodes, 5/30 (pN2).. Non-lymph node pericolonic tumor: Not identified. Distant metastasis (pM): Cannot be evaluated by the specimen (pMX) . Other findings:. None. 5 DIAGNOSIS Right colon, resection: - Adenocarcinoma, moderately differentiated, depth of invasion through muscularis propria.. Surgical margins uninvolved..  Metastatic adenocarcinoma in five of thirty lymph nodes (5/30). DIAGNOSIS
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diff --git a/output/text/e6dc21e7-81f5-4b2b-ae96-105a48ad07b0.txt b/output/text/e6dc21e7-81f5-4b2b-ae96-105a48ad07b0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d20c9af04bbc6583c01b11fa506005b4563b6c0b
--- /dev/null
+++ b/output/text/e6dc21e7-81f5-4b2b-ae96-105a48ad07b0.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+UUID: B660432A-A67B-40CC-89F8-80648DB8AE980 TCGA-C8-A26Y-01A-PR Redacted IRB APPROVED MultI-media systems, Inc. Form Revised Clinical Case Report. 1cs-0-3 (For Collection of Cancerous Tissue) Cauiona, nifiltnahng cluct, nos 8500f3 Sife: breaot, Nos c50.9 lw 5/3sf Informed Consent I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator Signature Date Clinical Information. AAOOSGENERALINFORMATION . Date of Birth (mm/dd/yyyy) Height Marital Status  Race Temperature.  Single Married Gender Weight  Divorced  Widow Blood Pressure Heart Rate 1218  Male XDFemale OOASNRHISTORYOEPRESENTILLNESS Symptoms: Clinical Findings:s A tumeur was found the Leff hreag Performance Scale (Karnofsky Score):  100 Asymptomatic   80-90 Symptomatic but Fully Ambulatory   60-70 Symptomatic, in bed less than 50% of day. Xj40-50 Symptomatic, in bed more than 50% of day, but not bed ridden     20-30 Bed Ridden AEONCURRENTMEDICATIONSs Drug Dose Route Frequency Date (mm/dd/yyyy) To 1 To / To To To
+
+--- Page 2 ---
+PAST MEDICAL HISTORY Diagnosis Date Treatment Status Diagnosis/Disease/Disorder/Injury POBGYNHISTORY # of Pregnancies Date of First Menses  Menopausal Status 0 5  Pre-menopausal # of Live Births  Peri-Menopausal Date of Last Menses jAPost-menopausal Don'+ Mromhe  IUD  Hormone Replacement   Oral Contraceptive Birth Control:  Condom Therapy:  Other: LOSOCALHISTORYT Environmental Hazards: Occupation: Smoking History Duration When Quit TYPE Packs/day Current Status (yrs) () O YES y0NO Alcohol Consumption Duration When Quit TYPE Drinks/day Current Status (yrs) (yr  yeS PNO Drug Use Duration When Quit Frequency TYPE Current Status (yrs) (yr  YES NO ETFAMILYMEDICAEHISTORYAAAW Age of Diagnosis Diagnosis Relative LABDATAW Date Test  Result Date Result Test CEA   Negative  Positive: HIV Negative  Positive:  Negative  Positive: i/ CA 15-3  Negative  Positive: Hep B CA 19-9   Negative  Positive: Hep C Negative  Positive:   Negative  Positive: PSA AFP  Negative  Positive: Other:  Negative  Positive: Other:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+Study Results Ultrasound X-Ray Date CT Endoscopy MRI Biopsy Boewst Casses Preoperative Clinical Diagnosis  Location of Suspected Involved Lymph Nodes Location of Suspected Distant Metastasis Clinical Staging T2 NO M o Date of Diagnosis Stage: -- Treatment Information Procedure Mgi?eo! Padica. Masteetmoss Date of Procedure Primary Tumor Organ Left bseast tumuR Detailed Location u0peR crToR Fuad(kayL3 x2 x 2 cm Size Extension of Tumor Lymph Nodes Description  Palpable, Non-Dissected Lymph Nodes Location of Lymph Nodes # of Lymph Nodes Dissected Lymph Nodes Distant Metastasis Organ Detailed Location Size  Surgical Staging T 2 No.. M Q. Stage: NEOADJUVENTTHERAPY (Chemo, Radiation Immuno Hormonalor Molecular) Drug/Treatment Dose Route Frequency Date (mm/dd/yyyy) To 1 To 1 To / To To
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by: Dat Preserved by: Dat SPECIMENTYPE(#ofSamplesprOvided). Frozen  Paraffin Block Blood/Serum/Plasma Slide Diseased  Normal Diseased  Normal Diseased Normal Diseased  Normal 3 3 2 3 2 2 Time to LN2 Time to Formalin Time to LN2 72 min min  min DMAAXTOPATHOLOGICAEDESCRIPTIONMASMNTSA Primary Tumor Organ Size Extension of Tumord Distance to NAT 3 x 2 x 2 cm|ecms erTee 6 eet haeast timen cm Lymph Nodes # Examined # Metastasized Location Distant Metastasis  Organ Detailed Location. Size Pathological Staging No m O Stage: I pT 2 Notes: BRexgFrodl li riitrage ( M, H2 )
+
+--- Page 5 ---
+Microscopic Description Cell Distribution Structural Pattern Diffuse p +  Streaming Mosaic Storiform Necrosis Fibrosis Lymphocytic Infiltration  Palisading Vascular Invasion Cystic Degeneration Clusterized Bleeding  Alveolar Formation Myxoid Change Indian File  Psammoma/Calcification CellularDifferentiton Squamous +-  Adenomatous +  Sarcomatous  Squamoid Cell Lymphomatous Glandular cell + Round Ceil Spindle Cell Cell Stratification Large Cell Fibroblast  Keratin  Secretion Small Cell Osteoblast RS Cell/RS Like Desmosome Intracyt. Vacuole  Lipoblast Pear! Inflam. Cell Gland formation x  Myoblast Plasma Cell Cellular Differentiation: Well Moderate  www NuclearAppearanceww*+*  Poor Nuclear Atypia: 0 1  Aniso Nucleosis II III Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity Nuclear Grade: Marker Result Value Date ER  Negative  Positive PR  Negative  Positive  Her-2/neu  Negative  Positive B-Cell Marker  Negative  Positive T-Cell Marker  Negative   Positive Other:  Negative  Positive Other:  Negative   Positive Final Pathology Report : Tpsil toe li g. oluc Tal cagceaem? Histological Diagnosis: f pssghe tale h. dieRastialed Grade:7 Comments: (M,,M2 nfeGx Ty'ceJ Principal invesuga. Pathologist Date 5
+
+--- Page 6 ---
+COnsOLIdated DIagnOstIc patholOgy fOrm* Microscopic Appearance: . Histological pattern: CELL DISTRIBUTION Diffuse STRUCTURAL PATTERN Mosaic x Streaming Necrosis  Storiform Lymphocytic Infiltration Fibrosis Vascular Invasion Palisading Chusterized Cystic Degeneration  Alveoiar Formation Bieeding Indian File 2. Cellular features:  Psammoma/Calcification Squamows Adenomatous Squamoid Cell + I Sarcomatous Glandular cel! +1 Lymphomatous Spindle Cell Round Cel! Cell Stratification + Large Cell Keratin Fibroblast Secretion Small Cetl Desmosome x Osteoblast Intracyt. Vacuole RS CelVRS Like  Lipoblast Peart  Gland formation Inflam. Cell KMyobiast Other wise Specified: Plasma Cell D1 5o% t Dr 9OZe Dz40 een s 2.Cellular Differentlation: Well Moderatcly Poor N Nuclear Atypia: Nuciear Appcarance Aniso Nucleosis Hyperchromatism Nucleolar Prominent Multinscleated Giant Cel! x Mitotic Activity Nuckear Grade Histological Diagnosis: Tnhltossss. Auetal lagei? ore Vot, :Clesns.. Lnorsh gceuss Comments:... Date PATHOLOGIST STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR ANDS
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diff --git a/output/text/e6dcf1bf-44f6-43da-ae7b-2085c6819746.txt b/output/text/e6dcf1bf-44f6-43da-ae7b-2085c6819746.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ddebdf9671f94ecadee9e88cff7c6283baff6ecb
--- /dev/null
+++ b/output/text/e6dcf1bf-44f6-43da-ae7b-2085c6819746.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+icp-0-3 Cavcinoma,mifjiRtrutingducta! nos 85ov/3 Poth?. Sitr: breast, urpw outw qusdrant c50.4 cQeF bret' no's C50.9 2//1 IR8 APPROVED hw inical Case Report. (For Collection of Cancerous Tissue) UUID:11F98715-1482-4D7D-9102-E362634806A7 TCGA-C8-A1HJ-01A-PR Redacted Informed Consentd I personally informed this patient that a sneciments) would be collected to be used for research purposes. I reviewed the FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator Signature Date Clinical Information B GENERAbINFORMATION+ Date of Birth (mm/dd/yxy) Height Marital Status Race Temperature 7.50y 37o c  Single Married Gender Weight  Divorced  Widow  Blood Pressure Heart Rate 120Zx2mm13 J8W/n Female SIG  Male .0 RAAHISTORYOEPRESENTILLNESS Chief Complaints:s Hhe Aenat hrealt No Clinical Findings: . Ne Emall nd Performance Scale (Karnofsky Score):  60-70 Symptomatic, in bed less than 50% of day  100 Asymptomatic 80-90 Symptomatic but Fully Ambulatory  20-30 Bed Ridden  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden  Frequency Date (mm/dd/yy) Drug Dose Route To / To To To To
+
+--- Page 2 ---
+PAST MEDICAL HISTORY: Diagnosis/Disease/Disorder/Injury Diagnosis Date. Treatment Status Heaill. WWOBGYNHISTORY.. Menopausal Status Date of First Menses # of Pregnancies  Pre-menopausal years ref /Per-Menopausal Date of Last Menses # of Live Births  Post-menopausal Jears ref Birth Control:  Condom  Oral Contraceptive 6 IUD  Hormone Replacement NO  Other: Therapy: CMRASOCIAEHISTORYO Environmental Hazards: Occupation: Smoking History Type  Packs/day Duration When Quit Current Statys (yrs) (yr)  yes  dNO Alcohol Consumption Duration When Quit Current Status TYPE Drinks/day (yrs) (v)  yes no Drug Use Duration When Quit Current Status TYPE Frequency. (vrs) (w)  yes  dno RCASAFAMILYMEDICAEHISTORYRI Age of Diagnosis  Diagnosis Relative Wrbody Crucer 0 MYSLABDATANS Date Test  Result  Date Test Result CEA   Negative  Positive: HIV LNegative  Positive: CA 15-3  Negative  Positive:  Positive: Hep B Negative   Negative  Positive: CA 19-9 Hep C   Negative  Positive: PSA   Negative  Positive: AFP Negative  Positive: Other:  Negative  Positive: Other:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+: .. .+* DIAGNOSTIC STUDIES.:........ Study Results Date Ultrasound X-Ray CT Endoscopy MRI Biopsy CA*CLINICALDIAGNOSISK**  Preoperative Clinical Diagnosis  Location of Suspected Involved'Lymph Nodes Location of Suspected Distant Metastasis Axilla NO Clinical Staging Date of Diagnosis T4h N1 Mo Stage: Treatment Information OW. OSURGIGALTREATMENTMASR. Procedure Date of Procedure Daty's Swrnerny  Primary Tumor Organ Detailed Location Size B8eart wper-rterqendraut 9.sx x cm Extension of Tumor NO Lymph Nodes Description  Location of Lymph Nodes. # of Lymph Nodes  Palpable, Non-Dissected Lymph Nodes Axila 10 Dissected Lymph Nodes Distant Metastasis Detaiied Location Size Organ TO  Surgical Staging Stage: LA T.9 N. M o. NEOADJUVENTTHERAPY(ChemoRadiatonImmanoHormonal or Molecular* Frequency Date (mm/dd/yyyy) Dose  Route Drug/Treatment To / To / NO To 1 To To 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by: Date: Time: Date: : . rime: Preserved by: aPECIMENTYPE#of samplo providedy Paraffin Block / Blood/Serum/Plasma Slide Frozen  Normal Diseased Normal Diseased Normal Diseased Normal Diseased x Time to Formalia Time to LN2 Time to LN2 min 10 mino min RNESARPATHOLOGICAEDESCRIPTIONENS Primary Tumor Extension of Tumor Distance to NAT Organ Size Yeeart 9.5* MU 2. cm x am Lymph Nodes # Metastasized Location # Examined 0 Axill Distant Metastasis Size Organ Detailed Location Pathological Staging M 0 N o Stage: pT2 Notes: 4
+
+--- Page 5 ---
+COnsOLIdatED DIagnOsTIC pAThOLOgy fORm* Microscopic Appearance: 1. Histological pattern: CELL DISTRIBUTION Diffuse +  STRUCTURAL PATTERN Mosaic  Streaming + Necrosis  Storiform Lymphocytic Infiltration x Fibrosis Vascular Invasion X Palisading. Clusterized Cystic Degeneration Alveola Formation Bleeding x Myxoid Change Indian File PsammomaCalcification 2. Cellular features:  Squamous + -Adenomatous Squamoid Cell + Sarcomatous Glandular cell + Lymphomatous Round Cell + Spindle Cell Cell Stratification Large Cell Fibroblast Keratin Small Cell  Secretion X. Osteoblast Desmosome RS CeIVRS Like Intracyt. Vacuole Lipoblast Inflam. Cell Pear! Gland formation  Myoblast herwis Specfied: pj8T% Dr80% Dr 80Z D4 7 O%  Plasma Cell Neekrts/ 2.Cellular Differentiation: Well Modermely Poor Nuclear Atypia: Nuckear Appearanst Aniso Nuckeosis Hyperchromatism  Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity Nuckear Grade Histological Diagnosis:/np/tpshy Duetw lat>cmg ts, 6-3 Comments: STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CONTRISUTOR 
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diff --git a/output/text/e6fddc6d-cdbf-492a-9ce7-a6adf033dc74.txt b/output/text/e6fddc6d-cdbf-492a-9ce7-a6adf033dc74.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6432ca891b6d2d66cc765f5fe9a796d6d35c1308
--- /dev/null
+++ b/output/text/e6fddc6d-cdbf-492a-9ce7-a6adf033dc74.txt
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+
+--- Page 1 ---
+Page 1 of 2 UUID:B3CFFF02-89AA-43AE-B19B-BEE6817AA997 Patient: TCGA-B6-A3ZX-01A-PR Redacted AP Surgical Pathology: Additional infod Surg Path CLINICAL HISTORY: Rule out malignancy of left breast. Palpable left breast mass within large axillary node.  If invasive carcinoma, please obtain ER, PR, EGFR, HER2/Neu by immunohistochemistry; for all 2+ IHc results please do FIsh analysis. GROSS EXAMINATION: A. "usncb left breast, number of cores 4, 11:00 site 1", received in formalin is a 1 x 0.6 x 0.2 cm aggregate of yellow-tan fibrofatty tissue which is submitted entirely in a mesh bag in block Al. B. "usncb left breast, number of cores 4, axilla site 2", received in formalin is a 0.9 x 0.6 x 0.2 cm aggregate of yellow-tan fibrofatty tissue which is submitted entirely in a mesh bag in block B1.. 1cD-O-3 axnXarci^oma,i^F1Hra Hi nq MICROSCOPIC EXAMINATION:S ducfJ 0ncl 1Obwar f5zz 13 Microscopic examination is performed.. 5i$:br<gst,^XS C5:9 7-ZaZ DIAGNOSIS : A. "LEFT BREAST, 11:OO, SITE ONE" (ULTRASOUND GUIDED NEEDLE CORE BIOPSY):S INVASIVE ADENOCARCINOMA OF THE BREAST.S HISTOLOGIC TYPE: DUCTAL, WITH LOBULAR FEATURES. NOTTINGHAM COMBINED HISTOLOGIC GRADE: 3 OF 3. TUBULE FORMATION SCORE: 3. NUCLEAR PLEOMORPHISM SCORE: 3. MITOTIC RATE SCORE: 2. IN-SITU CARCINOMA: PRESENT. TYPE OF IN-SITU CARCINOMA: SOLID. NUCLEAR GRADE OF IN-SITU CARCINOMA: 3 OF 3. ESTROGEN/PROGESTERONE RECEPTOR, HER2/NEU, AND EGFR ANALYSIS: PENDING.S PARAFFIN BLOCK NUMBER: A1. RESULTS WILL BE ISSUED IN A SEPARATE REPORT FROM THE IMAGE CYTOMETRYS LAB. B. "LEFT BREAST, AXILLA, SITE TWO" (ULTRASOUND GUIDED NEEDLE CORE BIOPSY) : LYMPH NODE WITH METASTATIC DUCTAL ADENOCARCINOMA. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es). Electronically signed:  ~: ADDENDUM 1: Please see for results of supplementary tests. I certify that I personally conducted the diagnostic evaluation of the above specimen(s) and have rendered the above diagnosis(es).
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diff --git a/output/text/e6fe05ac-dddb-4bd6-811f-46005db070c1.txt b/output/text/e6fe05ac-dddb-4bd6-811f-46005db070c1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8a1385cbd92af902fce60c2a01a64bb84dd59dfd
--- /dev/null
+++ b/output/text/e6fe05ac-dddb-4bd6-811f-46005db070c1.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+TSS 1cs-0-3 Carcmoma nifiItraHny ouctl, Nos 8500/3 Srte: bueot, NOs C50.9 SPECIMENS: H/15/ A. WLE RIGHT BREAST NEEDLE LOCALIZATION B. SENTINEL NODE #1 RIGHT AXILLA C. SENTINEL NODE #2 UUID:9786C438-4C7D-49FC-BA49-00D2DF41827D SPECIMEN(S): TCGA-E2-A1L9-01A-PR A. WLE RIGHT BREAST NEEDLE LOCALIZATION Redacted B. SENTINEL NODE #1 RIGHT AXILLA C. SENTINEL NODE #2 INTRAOPERATIVE CONSULTATION DIAGNOSIS: A-WLE right breast: Mass (1.4 x 1.2 x 1 cm) is 0.8 cm from the closest inferior margin. TPB/TPC-sentinel lymph nodes #1 & #2 right axilla: Negative for tumor by touch prep. Diagnoses called by Dr. to Dr. at GROSS DESCRIPTION: A. WLE RIGHT BREAST NEEDLE LOCALIZATION Received fresh labeled with the patient's identification and "WLE left breast needle localization" is a previously inked, oriented (single-anterior, double-lateral, triple-superior) 53-g, 4 x 3.4 x 2.5 cm needle Iocalized lumpectomy with radiograph. Ink code: Anterior-yellow, posterior-black, medial-green, lateral- red, superior-blue, inferior-orange. Specimen is serially sectioned from lateral to medial into 7 slices revealing a 1.4 x 1.2 x 1 cm firm, tan, stellate mass that is closest to the inferior margin at 0.8 cm. Tissue is procured; Representatively submitted: A1-A3: lateral margin, perpendicular sections A4: slice 2, anterior inferior A5: slice 3, anterior inferior A6: slice 3, mid inferior (mass) A7: slice 3, posterior inferior A8: slice 4, anterior inferior (mass) A9: slice 4, posterior inferior (mass) A10: slice 5, anterior superior A11: slice 5, posterior superior A12: slice 5, anterior inferior (mass) A13: slice 5, posterior inferior (mass) A14: slice 6, anterior inferior (mass) A15: slice 6, posterior inferior (mass) A16-A18: medial margin, perpendicular sections (muscle infiltrating the tissue) B. SENTINEL LYMPH NODE #1 RIGHT AXILLA Received fresh labeled with the patient's identification and "sentinel lymph node #1 right axilla" is a 4 x 2.3 x 1.5 cm lymph node; sectioned, it has a yellow-tan cut surface. A touch prep is performed;. submitted entirely in cassettes B1-82. C. SENTINEL LYMPH NODE #2 Received fresh labeled with the patient's identification and "sentinel lymph node #2" is a 3.4 x 3 x 0.4 cm lymph node; sectioned, it has a yellow-tan cut surface. Touch prep is performed; submitted entirely in cassettes C1-C3. DIAGNOSIS:E A. BREAST, RIGHT, WIDE LOCAL EXCISION: - INVASIVE DUCTAL CARCINOMA, SBR GRADE 2 WITH FOCAL NECROSIS, MEASURING 1.5-CM - 1NTERMEDIATE NUCLEAR GRADE, DUCTAL CARCINOMA IN SITU, SOLID AND CRIBRIFORM TYPES WITH CENTRAL NECROSIS - SURGICAL RESECTION MARGINS NEGATIVE FOR TUMOR - BIOPSY SITE CHANGES WITH FIBROSIS AND GRANULATION TISSUE - SEE SYNOPTIC REPORT. B. LYMPH NODE, SENTINEL #1, RIGHT AXILLA, EXCISION: - METASTATIC CARCINOMA TO ONE OF ONE LYMPH NODE (1/1), MEASURING 1.0-MM (MICROMETASTASES) WITH NO EXTRANODAL EXTENSION, SEE NOTE. C. LYMPH NODE, SENTINEL #2, RIGHT AXILLA, EXCISiON: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1).
+
+--- Page 2 ---
+TSS: NOTE: The touch preparation was reviewed, no tumor cells are identified. Therefore, the false negativity is due to sampling error.. SYNOPTIC REPORT - BREASTE Specimen Type: Excision Needle Localization: Yes - For mass Laterality: Right Invasive Tumor: Present Multifocality: No WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Tumor size:1.5cm Tumor Site: Not specified.  Negative Margins: Distance from closest margin: 0.7cm inferior Tubular Score: 2 Nuclear Grade: 2 Mitotic Score: 2 Modified Scarff Bloom Richardson Grade: 2 Necrosis: Present Vascular/Lymphatic Invasion: Present. Extent: focal Lobular neoplasia: None Lymph nodes: Sentinel lymph node only. Lymph node status: Positive 1 / 2 Yes Micrometastases: DCIS present Margins uninvolved by DCIS DCIS Quantity: Estimate 2% DCIS Type: Solid Cribriform DCIS Location: Associated with invasive tumor Nuclear grade: Intermediate Necrosis: Present ER/PR/HER2 Results ER: Positive PR: Positive HER2: Negative by IHC Performed on Case: Pathological staging (pTN): pT 1c N 1mi CLINICAL HISTORY:  None given PRE-OPERATIVE DIAGNOSIS: Cancer right breast Final ReviewPathologist, Final.., Pathologist,
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diff --git a/output/text/e6fef90c-5ac7-4acd-86b0-922785da750b.txt b/output/text/e6fef90c-5ac7-4acd-86b0-922785da750b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..585761419c398a10ca10690531797297f5386be0
--- /dev/null
+++ b/output/text/e6fef90c-5ac7-4acd-86b0-922785da750b.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:359D85F2-BD23-42E1-B316-9D908DBACD78 TCGA-D8-A73W-01A-PR Redacted Patient: XXX Age: Gender: F Unit in charge: IcD-O-3 Physician in charge:. StRYBusF nss cso.9 Clinical diagnosis (suspicion) Cancer of the right breast Date of admission:. Q io/5/3 Material: 1) Material: right breast and axillary tissue. Method of collection: Mastectomy and axillary lymph nodes. Histopathological diagnosis: Examination performed on: Invasive mucinous carcinoma of the right breast. Cancer metastases to the lymph node (1/13). (NHG2, pT3, pN1a). (8480/3 T-04915)* Macroscopic description: Right breast, sized 21 x 16 x 6 cm, removed along with armpit tissues sized 10 x 9 x 3 cm and a skin flap of 21 x 12 cm. Weight 1092 g. Tumour sized 5.5 x 4 x 4 cm found on the boundary of upper quadrants, placed 1 cm from the upper edge, 0.1 cm from the base and 1 cm from the skin. Status after core needle biopsy (test No. . Lymph nodes of 5.2 cm, fatty Microscopic description: Invasive mucinous carcinoma - NHG2 (2 + 2 + 3/20 mitoses/ 10 HPF - visual area 0.55 mm). The nipple without pathological lesions. Glandular tissue showing parenchyma atrophy. Invasive lesions removed 0.1 cm from the base. Axillary lymph nodes:. Cancer metastases to the lymph node (1/13). (metastasis of 0.5 transgressing the nodular capsule). Assistant: Pathologist: Edited by CONTACT YOUR DOCTOR WITH THIS REPORT!
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diff --git a/output/text/e75c630c-4205-4d53-8b86-e428c269b2b0.txt b/output/text/e75c630c-4205-4d53-8b86-e428c269b2b0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8ac86e370c33b8efef588aaefa1af711decf74b7
--- /dev/null
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+
+--- Page 1 ---
+To: P.9 33 ZOIAGNOSIS: Art 1: AxILLary ContentS. LEFt. ResecTIOn   METAStaTic ADEnOCARcinomA (1H, 1Q-1R and 1S-1T) inVOLVinG ThREe OF TwenTY-EiGh't LymPH NODES (3/z8). UP TO 1.5 Cm (1r). wiTH eXTrACAPsULAR ExTensiOn (0.2 Cm). B.  CHAngE8 CONSISTeNt wITh PReViOUS FinE nEEDLe ASPiRATiOn SITe. See PRIOR Part 2: Oreast. leet. segmental mAstectomy - MiCROCALCIFIcATIOnS. THE iNVASIVE TUMOr iNVOLVEs THE POSTERiOR RESECTION MARGIN (2A), The inFErIOR RESectiOn mArgin (2f, 2N andI 2O). AND COue5 tO wITHin 0.2 Cm FrOm thE anTEriOR REsection margIn (2h). B. The tumor 9ize is 3.6 x 2.5 x 1.7 cm. C. NOTTiNGhAm SCORE 6/9 (tUBULES 3. NUCLFI 2, MITOSIS 1). D. Lymphovascular Invasion is present. Ductal Carcinoma In Situ, soiJd AnD cribrIform Types. nuclEar grade 2, wiTH COmeDonecrosis, AssUciAteD micrOcALcifICATIOns anD reTrOgrADe CancerIZATiOn Of LOBules, representing about 2% of tumor volume. F. Ductal carcinoma in situ is Present aDmixeo with invasive tumor.e G. All. other margins of resection are Free of tumor. H. ATYPICAL DUCTAL HYPERPLASIA Ductal Papillomas. J.  RADial ScArs witH DUgtAL EpItHelIAl hyperplaSIa And Columnar CeLl ChAnGes. K.  PrOliferative fibrocysTic Changes wiTh Ductal epitheLial hyperpLasia, CoLumnAr CeLl Change8 and multifocal Sclerosing adenosis wIth associateD microcalciFications. L. ChAnges conSIstent wITh PreviOus BiOpsy SiTE, see pRIOr M.  ImmUnOhistOchemiCaL StAining fOR EsTrOgeN RecEDtnD D  2/NeU wErE PreviOUsLY PerFORmED ON CORE siOPSY 7!eAune Receptor anD her. Foi_lOws: estrogen recepror - positive, progesterone receptor - positive ano her-2/neu .  AND WERE REPORTED AS NEGATIVE (SCORE O). Part s: breast, Left, new posterior-Lateral margins, excision  MICROSCOPIC FOCUs OF InVAsiVE DUCtAL CARCInOmA (3E), COmING tO wITHiN 0.3 CM FrOm ThE NEW INKED RESECTION MARGIN (9ee comIment). Atypical Ductal hyperplasia. C. Ductal paPilloma.  RADtal scars wIth DuctaL EpitkeLial hyperplasia AnD Associated microcalciFicaTions. ChAnges aND EXTenSIvE 8CLerOsINg ADenDsiS WiTH AsSOciATeD mULTiFOCAL microcalcifications. F.  medial Cal.ciFicaTions Of BloOd Vessel. New resection margins are free of tumor. CASE synorsis: SyNOPTIC - PRIMARy iNVASIvE CARCINOmA OF BREAST LATERALITY: PROCEDURE: Loft LOCATION: Segmerntel SIZE OF TUMOR: Not apecified  MULTICENTRICITY/MUL TIFOCALITY OF INVASIVE FOCI:  Maxinum dimenslon invasiva cnniponent: 3.5 cm TUMOR TYPE (invaAivc componant): No 1e0-0-3 NOTTingHiam SCOre: Ductal adenocarcinmne. NOS Nuclcar grade: 2 cascinoma mfnHtnuAmsq duct, Nos 85oof3 Thbule formaton: 3 Mhotic araivity score: 1 S1h: brast, Nos C50.9 3/13/u pw Total Nottingham scora:  ANGIOLYMPHATIC INVASION: Nollingnam yrade (1. 2, 3). 2 Dermal Lymphatic invasiOn: YAS CALCIFICATION: Not uppllcshle Yes, benign zones Tumor TypE. in SItU: Yes. malignent zones Crbriform Solld DCIS adxod wili invanivy carrinoina SURGICAL MARGINS InVOLVEO BY InVASIVE COMPONENT: Percent of lumor occupied by in situ componcnt: 2 % SURQ mARGiNS InVOLVED By IN SITU COmPONEnT: Yes, diffuso Lymph nodes Posrtive: No Lymph nodes examined: 3 METhOD(S) OF LYMPH NODE EXAMiNATION: 28 SENTINEL NODE METASTASIS: H/E st in SiZE OF NODAl mETASTASES: No Lymph node metastasis(-es) with extracapsijlar extension: Diamcler of larguut lympn nnde motastows: 15 mn FALE UALIFIE NON-NEOPLASTIC BREAST TiSSUE: ADH, Rudiai sCur, PanillonA, FCU Ye6 M 3/13/11 t stage, Pathologic: n stage, Pathologic: pt? M STAGE. PATHOLOGIC: nN1a ESTROGEN RECEPTORS: nMX UUID:79822278-2BA1-4904-BCA6-281368C77475 PROGESTERONE RECEPTORS:  poshive TCGA-BH-AODH-01A-PR HER2/NEU: posttive Redacted ZCIo or 1+
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diff --git a/output/text/e78e73dd-9187-4975-ad99-30f22a4936f8.txt b/output/text/e78e73dd-9187-4975-ad99-30f22a4936f8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7c75aedd2070e550c4f4492ee3505fa9c7bb820d
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+SPECIMENS: A. RECTUM, SIGMOID COLON AND ANUS B. COLON SPECIMEN(S): A. RECTUM, SIGMOID COLON AND ANUS B. COLON GROSS DESCRIPTION: A. RECTUM, SIGMOID COLON AND ANUS Received fresh and labeled with the patient's name "A - rectum, sigmoid colon and anus", is a closed segment of colon including anus and rectum measuring 32.0 cm in length with the proximal circumference of 4.6 and distal of 7.1 cm. The serosa is unremarkable. There is a fungating polypoid mass with serpentine borders measuring 2.3 cm in length with a width of 2.4 cm located 0.5 cm from the dentate line and 4.9 cm from the anal resection margin. The epicenter of the tumor is 1.8 cm from the dentate line. It is approximately 24.0 cm from the proximal margin. In the lower portion of the rectum are additional polyps ranging from 0.1 to 0.3 cm. In the mid portion of the specimen are polyps ranging from 0.1 to 0.3 and in the proximal region diverticuli are seen. Sections of mass and normal appearing mucosa are submitted for procurement. Representative sections are submitted as follows: A1: Proximal margin A2: Distal margin A3-A6: Sections of mass and deep margin A7: Polyps proximal to mass A8-A9: Polyps from mid portion of specimen to proximal region A10: Diverticula A11: Normal appearing mucosa A12: Proximal, 5 possible lymph nodes A13: Proximal, 1 bisected lymph node A14-A17: Distal, 6 possible lymph nodes each A18-A21: Distal, 2 bisected lymph nodes each B. COLON Received fresh and labeled with the patient's name "B - colon", is a closed segment of colon including terminal ileum, cecum, and right colon measuring approximately 60.0 cm in length. The serosa is unremarkable. There is attached vermiform appendix measuring 8.2 cm in length with a diameter of 0.9 cm. The specimen is opened and the portion of terminal ileum is 6.9 cm in length with an internal circumference of 3.9 cm. Within the cecum is a firm indurated polypoid lesion with serpentine borders measuring 5.8 x 5.2 x approximately 0.9 cm in depth. It is located adjacent to the ileocecal valve and 6.5 cm from the proximal margin. It extends through the muscularis propria and areas of necrosis and hemorrhage are seen. Throughout the colon there are polyps ranging from 0.2 to 0.6 cm. Within the distal portion of the specimen there are diverticuli. Sections of mass and normal mucosa are procured. Representative sections are submitted as follows: B1: Proximal margin B2: Distal margin B3-B8: Sections of mass.  B9: Polyps proximal to mass. B10-B11: Polyps distal to mass B12: Diverticuli B13: Normal appearing mucosa and appendix B14-B17: proximal, 6 possible lymph nodes each B18: proximal, 1 lymph node B19-B23: proximal, 2 bisected possible lymph nodes each B24-B30: distal, 6 possible lymph nodes each B31-B32: distal, 1 possible lymph node each DIAGNOSIS: A. ANUS, RECTUM, SIGMOID, RESECTION: - INVASIVE, MODERATELY DIFFERENTIATED, ADENOCARCINOMA, INVOLVING MUSCULARIS PROPRIA, PRESENT 1.8 CM FROM THE DENTATE LINE, MEASURING 2.4 CM  SURGICAL RESECTION MARGINS ARE NEGATIVE FOR TUMOR - METASTATIC CARCINOMA TO FOURTEEN OF FORTY-THREE LYMPH NODES (14/43) LARGEST MEASURING 0.5 CM WITH EXTRANODAL
+
+--- Page 2 ---
+EXTENSION - MULTIPLE HYPERPLASTIC POLYPS AND A DIVERTICULUM - SEE SYNOPTIC REPORT AND SEE NOTE. B. RIGHT COLON AND TERMINAL ILEUM, RESECTION: - INVASIVE. MODERATELY DIFFERENTIATED ADENOCARCINOMA WITH. NECROSIS, INVOLVING SUBSEROSA, PRESENT IN THE CECUM, MEASURING 5.8 CM - SURGICAL RESECTION MARGINS ARE NEGATIVE FOR TUMOR - METASTATIC CARCINOMA TO ONE OF SIXTY-SIX LYMPH NODES (1/66),  MEASURING 1.0 MM - APPENDIX AND ILEUM, NO SPECIFIC PATHOLOGIC CHANGES - SEE SYNOPTIC REPORT AND SEE NOTE Note: Immunohistochemistry for mismatched repair proteins and MSI testing have been ordered on both tumors and addendum report to follow. SYNOPTIC REPORT - ANUS Specimens Involved Specimens: A: RECTUM, SIGMOID COLON AND ANUS Specimen Type: Abdominoperineal resection Tumor Site: Unspecified Distance from dentate line: 1.8cm Tumor Size: Greatest dimension: 2.4cm Additional dimensions: 2.3cm Tumor Configuration: Polypoid WHO CLASSIFICATION Carcinoma Adenocarcinoma 8140/3 Histologic Grade: G2: Moderately differentiated Extent of Invasion: Confined to the anus Margins: Proximal Margin: Uninvolved by invasive carcinoma Distal Margin: Uninvolved by invasive carcinoma Radial Margin: Uninvolved by invasive carcinoma Distance of invasive carcinoma from closest margin:. 0.7cm Angiolymphatic Invasion: Absent Perinueural Invasion: Present Carcinoma In Situ: Absent Additional Pathologic Findings: Hyperplastic polyps, diverticulum Lymph Nodes: Total Positive 14 / 43 Perirectal Positive 14 / 43 Pathological Staging (pTNM):  pT 2 N 1 M X SYNOPTIC REPORT - COLON & RECTUM Specimens Involved Specimens: B: COLON Specimen Type: Right hemicolectomy Tumor Site: Cecum Tumor Configuration: Exophytic (polypoid) Tumor size: 5.8cm Additional dimensions 5.2cm x 0.9cm WHO Classification Adenocarcinoma 8140/3 Histologic Grade: G2: Moderately differentiated Extent of Invasion: Subserosa Margins:  Margin(s) uninvolved by invasive carcinoma (Proximal, Distal, Radial) Distance of invasive carcinoma from closest margin:. 0.8cm
+
+--- Page 3 ---
+Margin: Radial Venous/Lymphatic Invasion: Absent Perineural Invasion:  Absent Additional Pathologic Findings: None identified Extent of Resection: Ro: Complete resection with grossly and microscopically negative margins Lymph Nodes: Positive 1 / 66 Extranodal extension: Absent Implants: Absent Pathological Staging (pTNM): pT 3 N 1 M X CLINICAL HISTORY:  None given PRE-OPERATIVE DIAGNOSIS: Colon ca ADDENDUM: ANALYSIS OF MISMATCH REPAIR PROTEIN EXPRESSION SUMMARY OF IMMUNOHISTOCHEMISTRY/SPECIAL STAINS Material: Block A6 Population: Tumor Cells Stain/Marker:Result: Comment: MLH1 Positive MSH2 Positive MSH6 Positive PMS2 Positive Material: Block B7  Population: Tumor Cells Stain/Marker:Result: Comment: MLH1 Positive MSH2 Positive MSH6 Positive PMS2 Positive The interpretation of the above immunohistochemistry stain or stains is guided by published results in. the medical literature, provided package information from the manufacturer and by internal review of staining performance and assay validation within the Immunohistochemistry Laboratory of the. The use. of one or more reagents in the above tests is regulated as an analyte specific reagent (ASR). These tests were developed and their performance characteristic determined by the Department of Pathology Laboratory at. They have not been cleared or approved by the U.S. Food and Drug Administration.. The FDA has determined that such clearance or approval is not necessary. INTERPRETATION: No abnormalities in mismatch repair protein expression identified. Expression of MLH1, MSH2, MSH6, and PMS2 in the tumor was evaluated by immunohistochemistry. Peritumoral lymphocytes and normal glands serve as internal positive controls expressing MLH1,. MSH2, MSH6, and PMS2. Testing for Microsatellite Instability has been ordered. The results will be issued in a separate report..
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diff --git a/output/text/e798cbcd-c0e6-43fd-a6bc-bb37a8bbfe4d.txt b/output/text/e798cbcd-c0e6-43fd-a6bc-bb37a8bbfe4d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1a6c8ae1052f7469823a4392c27425b2feaf7917
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+DIAGnosis:  Kidney, left, nephrectomy:  Renal cell carcinoma, chromophobe type, Furhman nuclear grade 2, extending to the perihilar sinus.  No capsular invasion seen. Vascular and ureteral margins of resection clear.. Kidney Nephrectomy Summary Table Macroscopic. Specimen Type: Nephrectomy Laterality: left. Tumor Size: 7 x 5.5 x 3.5 cm Microscopice Histologic Type: Chromophobe Histologic Grade: Furhman grade 2 Extent of Invasion. Primary Tumor(pT): T3 Regional Lymph Nodes(pN): NX Distant Metastisis(pM): Mx Margins: Extends to perihilar sinus CLINICAL INFORMATION: Brief Clinical History: large. left renal mass, bx chromophobe Patient Identification. Page 1 of 3
+
+--- Page 2 ---
+PROcEDuRE: Pre-Operative Diagnosis: left renal mass Post-Operative Diagnosis:. left renal mass Operative Findings: large left renal mass. SPECIMENS SUBMITTED: 1. KIDNEY, LEFT GROss DEscRIPTION: One specimen is received fresh with the patient's name, medical record number and further specified as "left kidney". It consists of a radical nephrectomy specimen weighing 323 grams and measuring 16 x 9.5 x 4 cm with surrounding fat. During procurement, a cut is made in the center to reveal a tan- red mass measuring 7 x 5.5 x 3.5 cm occupying the center of the kidney and involving the hilum. Approximately 2.5 x 2 x 2 cm of tumor tissue is procured for.  Approximately 1.5 x 1.5 x 1 cm of normal tissue is procured for the A 1 x 1 x 1 cm of normal tissue was procured for the. The procurement was performed by In the Gross Room, the specimen matches the above description. The adipose tissue and hilar region is inked in black. The ureter is identified and measures 6 cm in length and up to 0.4 cm in diameter. Upon sectioning, it appears that the tumor has invaded the hilum and the perirenal, perihilar fat. Large vessels and ureter appear grossly free of tumor. In the anterior aspect of the kidney, there is an area of adhesion between the capsule and the tumor, suspicious for invasion of perirenal fat. Very small amounts of adrenal tissue measuring 2 x 0.3 cm is identified in the upper pole. Sectioning the tumor appears to have a central necrosis. On further sectioning, it appears that the mass is away from the periphery of the kidney and involves the primary the hilar region. The tumor appears to abut a dilated calyx and the pelvic ureter without invading it. Representative sections are submitted as follow: A vascular margin, B adrenal tissue, C-F tumor and hilar region, G tumor and dilated pelvic region, H kidney with adhesion on capsule L ureter margin  M - O tumor Gross description dictated by No consultants Patient Identification Page 2 of 3
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+Patient Identification Page 3 of 3
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diff --git a/output/text/e7a1a3a5-a608-4dc1-923c-dc4595c894ac.txt b/output/text/e7a1a3a5-a608-4dc1-923c-dc4595c894ac.txt
new file mode 100644
index 0000000000000000000000000000000000000000..21a8aecb848cb065f8744a16afdee2b65cd865a9
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+1cs-0-3 Adinocarcinome, mucincns,Ne5 8480j3 UUID:73512C13-D2EB-4E6C-9A26-3759252F385A Site wd: Siymid elon, C18, 7 i1ofn lu TCGA-DM-A1D7-01A-PR Redacted (First Tumor) Tumor Site: Sigmoid Distal Date of Cancer Sample Procurement: Histology: Adenocarcinoma Description of other histology: Grade: Moderately Differentiated Mucinous:  Yes C No  Yes C Unknown (Focal) C Yes Signet Ring Feature: 6 No : Yes r Unknown (Focal) Histologic Heterogeneity:  No C Yes C Unknown Host Response: Lymphoid Aggregates Crohn's like reaction r None  Yes r Unknown Plasma cell rich stroma C No C Yes C Unknown Growth Pattern: C Expansile C Expansile  Invasive C Unknown and Invasive Inflammatory Bowel Disease  No  Yes C Unknown Angiolymphatic invasion:.  No C Yes C Unknown Mutator Phenotype: C No  Yes C Unknown Number of Slides 1 Garland Necrosis present:. r No ( Yes  Yes C Unknown (Focal) TiL Cells / HPF .4 Pathologist Comment: HIFAA Discrepanc Prior Malignancy Deal/Synchronoust Case is (circle) Reviewer initials
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diff --git a/output/text/e7c1849a-bc75-4b53-9322-0f155cc31905.txt b/output/text/e7c1849a-bc75-4b53-9322-0f155cc31905.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c5302f9d3c791f68ec1211103f02f964a5094909
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+SPECIMENS: A. RIGHT COLON TERMINAL ILEUM DIAGNOSIS: RIGHT COLON AND TERMINAL ILEUM, ILEOCOLECTOMY: 1) INFILTRATING POORLY DIFFERENTIATED ADENOCARCINOMA OF COLON WITH MEDULLARY FEATURES INVADING THROUGH MUSCULARIS PROPRIA INTO SUBSEROSA. TUMOR SIZE: 7x5x1.2 CM - MARGINS OF RESECTION, NO TUMOR SEEN. - TWENTY THREE LYMPH NODES, NEGATIVE FOR METASTASIS (0/23) 2) MULTIPLE TUBULAR ADENOMAS AND HYPERPLASTIC POLYPS OF ASCENDING COLON COLORECTAL CANCER TEMPLATE Tumor Size (cm): 7x5x1.2 cm. Histologic Type: Adenocarcinoma Grade/Differentiation: Grade 3 with medullary features. Invasion Depth: Subserosa  Invasion Vasc/Lymphatic: Absent Invasion Perineural: Absent Extension to Adj. Areas: NA Margins: Free Lymph Nodes: Negative (0/23) Stage Pathology: pT3N0 MX Implants: Absent Precursor:  Present, tubular adenomas and hyperplastic polyps Non-neoplastic areas:. NA SPECIMEN(S): A. RIGHT COLON TERMINAL ILEUM CLINICAL HISTORY: NA GROSS DESCRIPTION: A. RIGHT COLON, TERMINAL ILEUM Received fresh and subsequently fixed with matching patient name and requisition number is a 30cm right hemicolectomy specimen consisting of a 5cm in length, 2cm in circumference terminal ileum segment and 25cm in length, 6cm average circumference right colon with moderate amount of pericolonic fat and surgically absent appendix. There is a 7x5x1.2cm light tan fungating tumor mass Iocated in the proximal cecum, 2.5cm from the ileocecal valve, 7cm from the proximal and 17cm from. the distal margin. Cut section of the tumor shows it is penetrating the muscularis propria and focally extending into the subserosal fat. Tumor tissue has been procured. There are multiple flat sessile polypoid lesions scattered in the right colon, ranging from 0.2cm in greatest dimension to 1.0x0.7x0.5cm. The most distal one is more than 1cm away from the distal surgical margin. The uninvolved colonic mucosa as well as the terminal ileum have kept its normal rugosity and are grossly. unremarkable. The mesenteric fat is thoroughly dissected and all Iymph nodes are submitted for microscopic examination. Representative sections are taken as follows:. A1-A7: representatives of the tumor A8: three polypoid lesions. A9: one polypoid lesion, bisected. A10-A11: one polypoid lesion, serially sectioned A12: four polypoid lesions A13: the most distal polyp A14: representatives of the uninvolved colonic mucosa A15: distal surgical margin. A16: proximal surgical margin and uninvolved terminal ileum A17: 6 presumptive lymph nodes. A18: 2 bisected lymph nodes, one inked black A19: 2 lymph nodes, larger one bisected. A20: 2 bisected lymph nodes, one is black.
+
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+ A21: 2 bisected lymph nodes, larger is grossly positive A22: 1 lymph node, serially sectioned A23: 3 presumptive lymph nodes A24: 1 bisected lymph node A25: 1 bisected lymph node A26: 2 bisected lymph nodes, 1 inked black A27: 2 lymph nodes
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diff --git a/output/text/e7ceeec8-33a0-4bfa-bb1b-331f4392e8cc.txt b/output/text/e7ceeec8-33a0-4bfa-bb1b-331f4392e8cc.txt
new file mode 100644
index 0000000000000000000000000000000000000000..04fd6e9dcc15c4bdc93a0b765900939aed146518
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+5/4/ 1cs-0-3 Carcnonnn infiIfratirg duct-Nos 85oo/3 Sit: brust, Nos c5o.9 34 DIAGNOSIS (A) SENTINEL LYMPH NODE #1, RIGHT AXILLA, BIOPSY: One benign lymph node (0/1). Cytokeratin stain shows no evidence of metastatic carcinoma. (B) SENTINEL LYMPH NODE #2, RIGHT AXILLA, BIOPSY: One benign lymph node (0/1). Cytokeratin stain shows no evidence of metastatic carcinoma. (C) ( RIGHT BREAST, SEGMENTAL MASTECTOMY: INVASIVE DUCTAL CARCINOMA OF BREAST, WITH SOLID PAPILLARY GROWTH PATTERN, MODIFIED BLACK'S NUCLEAR GRADE 1 (WELL DIFFERENTIATED). INVASIVE CARCINOMA MEASURES 2.7 CM IN GREATEST DIMENSION. Lymphatic/vascular invasion not identified. INTRADUCTAL CARCINOMA (DCIS), MODIFIED BLACK'S NUCLEAR GRADE 1 (LOW GRADE), CRIBRIFORM AND PAPILLARY TYPES, WITHOUT NECROSIS. INTRADUCTAL CARCINOMA (DCIS) PRESENT ADMIXED WITH AND ADJACENT TO THE INVASIVE COMPONENT, COMPRISING APPROXIMATELY 5% OF THE TUMOR. Surgical margins are free of tumor.. INVASIVE CARCINOMA IS 1 MM TO THE CLOSEST ANTERIOR (SUPERFICIAL) MARGIN, 5 MM TO THE CLOSEST POSTERIOR (DEEP) MARGIN. INTRADUCTAL CARCINOMA (DCIS) IS 2 MM TO THE CLOSEST ANTERIOR (SUPERFICIAL) MARGIN. Biopsy site changes. Focal fibrocystic change. (D) ADDITIONAL SUPERIOR MARGIN AND LESION AT 9 O'CLOCK, EN BLOC EXCISION: Benign breast parenchyma, no evidence of malignancy. A small capillary hemangioma Fibrocystic changes including focal ductal hyperplasia with and without atypia, columnar cell alteration, apocrine metaplasia, tibroadenomatoid change, cyst formation and pseudoangiomatoid stromal fibrosis.. Microcalcifications are present in benign ducts. (E) SUPERFICIAL INFERIOR MARGIN, EXCISION: Benign breast parenchyma, no evidence of malignancy. Fibrocystic changes including focal florid ductal hyperplasia without atypia, columnar cell hyperplasia, apocrine metaplasia and cyst formation.. (F) ADDITIONAL DEEP MARGIN, EXCISION: Benign breast parenchyma, no evidence of malignancy. UUID:18D46E96-4E16-4736-AACF-C6BF8AEC9368 TCGA-GM-A2DM-01A-PR Redacted ADDITIONAL MEDIAL MARGIN, EXCISION: Benign breast parenchyma, no evidence of malignancy. (H) ADDITIONAL SUPERFICIAL MEDIAL MARGIN,, EXCISION: Benign breast parenchyma, no evidence ot malignancy.
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+(I) ADDITIONAL SUPERFICIAL LATERAL MARGIN, EXCISION: Benign breast parenchyma, no evidence of malignancy.. (J) ADDITIONAL SUPERFICIAL INFERIOR MARGIN, EXCISION: Benign breast parenchyma with tocai minimal atypical ductal hyperplasia.. Entire report and diagnosis completed by ' COMMENT Please see for the results of prognostic markers.. GROSS DESCRIPTION (A) RIGHT AXILLARY SENTINEL LYMPH NODE #1, BLUE, COUNT 8 - A single ovoid, pink-tan lymph node (2.0 x 1.0 x 1.0 cm) is serially sectioned and touch preps made (touch preps 1-4) and entirely submitted in cassettes A1 and A2. TP/DX: NO TUMOR PRESENT (B) RIGHT AXILLARY SENTINEL LYMPH NODE #2, BLUE, COUNT 153 - A portion of yellow fibroadipose tissue (4.0 x 2.0 x 1.0 cm) contains a single fatty, gray to white lymph node (2.8 x 1.8 x 0.8 cm). The lymph node contains a 0.4 cm white nodule. The specimen is serially sectioned, touch preps 1-4 made and a frozen section done, submitted entirely in cassettes B2 and B3. *FS/DX: NO TUMOR PRESENT. (C) RIGHT SEGMENTAL MASTECTOMY, SHORT DOUBLE STITCH SUPERIOR, LONG DOUBLE STITCH LATERAL, LONG SINGLE STITCH DEEP - A right segmental mastectomy specimen, oriented by the surgeon, 7.8 x 6.0 x 1.5 cm. The specimen was sectioned from superior to inferior in eight slices. Within the center of the specimen is a 2.7 x 2.5 x 1.7 cm well-circumscribed pink-tan friable mass, located at the anterior margin, 1.3 cm from the lateral, 2.2 cm from the medial margin and 2.0 cm from the deep margin.. There is a 0.5 x 0.4 x 0.4 cm nodular firm area in slice #6, possibly representing previous biopsy site, 0.3 cm trom the medial margin and 1.0 cm from the superticial margin. The breast tissue surrounding the mass is composed of greater than 90% yellow adipose tissue. No additional masses are identified.. INK CODE: Blue - superior, green - inferior, yellow - anterior, black - deep, red - medial, orange - lateral. SECTiON CODE: C1, slice #4, lateral; C2, slice 4, lateral; C3, slice 4, tumor and anterior margin; C4, slice 4, deep margin; C5, slice 4, medial margin; C6, slice 5, lateral margin; C7, slice 5, tumor and anterior margin; C8, slice 5, tumor and deep margin; C9, slice 5, anterior; C10, slice 5, deep margin; C11, slice 6, tumor and medial margin; C12, slice 7, tumor and anterior margin; C13, slice 7, media/anterior margin; C14, slice 8, interior margin; C15, slice 1, superior margin; C16, slice 3, representative uninvolved breast tissue; C17, slice 6, 0.5 cm nodule with anterior/medial margin.. (D) EN BLOC EXCISION, ADDITIONAL SUPERIOR MARGIN AND LESION AT 9 O'CLOCK (STITCH SUPERIOR MARGIN) - A tan-yellow tibrotatty irregular soft tissue fragment( 7.0 x 5.5 x 2.0 cm) with a suture at an edge of the specimen. The specimen is arbitrarily oriented in the form of a clock with suture designated as 12 o'clock. The tace of the clock has a tibrotic area (3.0 x 2.0 cm). The back of the clock is predominantly fatty. The specimen is serially sectioned from 3 to 9 o'clock. The fibrotic area seen on the face of the clock extends to the 12 o'clock edge and measures 4.0 x 3.5 x 0.8 cm. The remainder of the specimen shows fatty tissue.. INK CODE: Green - 9 to 3 o'clock edge. Black - 3 to 9 o'clock edge. Yellow - face of the clock. Blue - back ot the clock. SECTION CODE: D1-D39, specimen entirely submitted from 3 to 9 o'clock. (E) SUPERFICIAL INFERIOR MARGIN, STITCH TRUE MARGIN - A tan-yellow fatty fragment (5.0 x 4.0 x 1.7 cm) with a stitch on one side. A 1.0 cm white tirm area is present abutting the inked margin with central tat necrosis and a 0.4 cm cyst. INK CODE: Black - true margin.. SECTION CODE: Specimen is entirely submitted in E1 to E14. (F) ADDITIONAL DEEP MARGIN, STITCH AT TRUE MARGIN - A tan-yellow specimen (3.5 x 2.4 x 1.8 cm) with a stitch on one side. The side with the stitch is inked black. The specimen is entirely submitted in F1 to F7. i (G) ADDITIONAL MEDIAL MARGIN, STITCH = TRUE MARGIN - A tan-yellow fatty specimen (4.5 x 2.5 x 1.7 cm) with stitch on one side. The side with the stitch is inked black. The specimen is entirely submitted in C1-C8. (H) ADDITIONAL SUPERFICIAL MEDIAL MARGIN, STITCH = TRUE MARGIN - A tan-yellow fatty tissue specimen (3.5 x 2.5 x 2.0 cm) with a stitch on one side. An irregular fragment fibrotic area is present in the specimen focally abutting the inked true margin. INK CODE: Black - true margin.. SECTION CODE: Specimen is entirely submitted in H1-H8.
+
+--- Page 3 ---
+(1) ADDITiONAL SUPERFICIAL LATERAL MARGIN - A tan-yellow fatty tissue specimen (2.9 x 1.5 x 0.9 cm) with suture on one side. The suture side is inked black. The specimen is entirely submitted in I1-I3. (J) ADDITIONAL SUPERFICIAL INFERIOR MARGIN, ST!TCH = TRUE MARGIN - A tan-yellow fatty tissue specimen with focal tibrosis (3.0 x 3.0 x 1.0 cm) with a stitch on one side. The side with the stitch is inked black. The specirmen is entirely submitted in J1-J5. CLINICAL HISTORY None given. SNOMED CODES T-04050, M-85003, M-85002 "Some tests reported here may have been developed and performance characteristics determined by These tests have not been specitically cleared or approved by the U.S. Food and Drug Administration." Released by: ---END OF REPORT---
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diff --git a/output/text/e8040688-e44e-4ec9-9359-35dcd8082d5e.txt b/output/text/e8040688-e44e-4ec9-9359-35dcd8082d5e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6dffedc8842e35e8fd7b10f0e85bf83b1f838750
--- /dev/null
+++ b/output/text/e8040688-e44e-4ec9-9359-35dcd8082d5e.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:28ADDF38-07FD-4354-8F17-C0E4310514C9 Redacted ICD03 Accession: Specimen Date/Time: DIAGNOSIS FJ 6/h31i4 (A) TISSUE FROM LEFT ORBIT: CONSISTENT WITH RECURRENT MELANOMA, SPINDLED B MORPHOLOGY, See COmment. COMMENT The tumor is viable with minimal necrosis < 5%. Focal background fibrous tissue is present invaded by tumor, the remainder of the. sample is tumor. The morphology is consistent with the prior history of uveal melanoma.. PATHOLOGIC STAGE BASED ON PATHOLOGY MATERIAL REVIEWED IN THIS ACCESSION NA- recurrence GROSS DESCRIPTION (A) TISsUE FROM LEFT ORBIT -- Multiple black, red, soft tissue fragements without discernible normal tissue ( 3 x 2 x 0.3 cm in aggregate). Portion of tissue submitted per protocol. Remainder of tissue submitted in A1-A4.. BIOMARKER TESTING Recurrence - local Tumor Block: A4 CLINICAL HISTORY History of uveal melanoma of the left eye SNOMED CODES T-D1480, M-87203 "Some tests reported here may have been developed and performance characteristics determined by. These tests have not been specificaly cleared or approved by the U.S. Food and Drug Administration."d Entire report and diagnosis completed by: -EnD Of repOrt- This case aUowakle,pw NcE Phogem Opfrce l yi414
\ No newline at end of file
diff --git a/output/text/e81b825d-8db0-49df-a74e-e9658727f5b6.txt b/output/text/e81b825d-8db0-49df-a74e-e9658727f5b6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..658648ab9978a38c6c17d0062047880bce6c3714
--- /dev/null
+++ b/output/text/e81b825d-8db0-49df-a74e-e9658727f5b6.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID: 7D5763F7-7284-4AF5-B8FC-5D8B5CB7F495 TCGA-A7-A0D9-01A-PR Redacted 1cs-0-3 Carcli vMn m`fi/+ruHNq cuA Nos 85oo/3 Sit: bresst 'N05 C5O.9 hw yofnf SPECIMEN A. Left axillary sentinel node B. Left breast cancer CLINICAL NOTES CLINICAL HISTORY: -year-old female with multifocal breast cancer. FROZEN SECTION DIAGNOSIS FsA) Left axillary sentinel node - Negative for metastatic carcinoma. GROSS DESCRIPTION A. Submitted fresh for frozen labeled "left axillary sentinel node" consists of a nodular mass of fat-covered. soft tissue 2 x 1 x 0.5 cm. Bisecting it reveals a rim of red-tan lymphoid tissue with a central fatty core. Submitted entirely for frozen section. B. Received fresh, subsequently fixed in formalin, labeled "left breast" is a 21 x 20 x 5.5 cm breast which is. partially covered with an 8.5 x 6 cm white-tan wrinkled skin ellipse. No scars are grossly identified on the skin. The specimen has a suture designating superior. The specimen is inked at the deep margin and sectioned from medial to lateral to show a yellow-white fibrofatty cut surface. There is a large firm nodule which is inferior central, measuring 3.5 x 2.5 x 3 cm. This comes within 2.5 cm of the deep margin and greater than 8 cm from the superior-inferior medial and lateral margins. The lateral aspect of this focus shows hemorrhagic tissue which is grossly consistent with the previous biopsy site. Representative sections of the tumor are submitted for tissue procurement. Also located in the inner upper quadrant is a hemorrhagic cavity which is 1.7 cm in greatest dimension, filled with white rice-like pellets.. This comes within 2.7 cm of the deep margin, 5 cm from the superior margin, 6 cm from
+
+--- Page 2 ---
+GROSS DESCRIPTION the medial margin and greater than 10 cm from the inferior and lateral margin. The apex of the specimen is sectioned and palpated to identify no discrete gross lesions or lymph nodes grossly identified. The remainder of the specimen is sectioned and palpated to identify no other discrete gross lesions identified. Representative sections of the specimen are submitted as follows. Block 1 - Entire nipple with representative skin; block 2-4 - representative section of tumor which includes representative deep margin; blocks 5-7 - representative section of biopsy site in inner upper quadrant with representative deep margin; block 8 - representative lower inner quadrant; block 9 - representative lower outer quadrant; block 10 - representative upper outer quadrant; block 11 - representative central breast. Rs-11 (8 through 11 show representative deep margins). MICROSCOPIC DESCRIPTION Invasive carcinoma: Histologic type: Invasive ductal carcinoma. Histologic grade:. 2 Overall grade: Architectural score: Nuclear score: 3 Mitotic score: 1 Greatest dimension (pT): Residual tumor measures 3.5 x 2.5 x 3 cm (pT2) Specimen margins: Deep margin of the mastectomy is free of tumor. Vessel invasion: Negative. Calcification: Positive. Nipple: Free of tumor. Invasion of skin or chest wall: Absent.
+
+--- Page 3 ---
+MICROSCOPIC DESCRIPTION Ductal carcinoma in situ: Histologic pattern:  Solid and cribriform (multifocal). Nuclear grade: 3 Central necrosis: Present Tumor size (if pure in situ): Residual Dcis at the second. biopsy site measures maximally 1.9 cm. % Dcis of total tumor (if mixed): 10% of the tumor at the. invasive site. Extensive intraductal component (present/absent): Absent. Specimen margins: Deep margin of mastectomy is free of tumor. Calcification: Positive. Description of non-tumorous breast: Post-biopsy changes are present. Lymph nodes: Number of positive nodes of total: 0 of 1 (sentinel lymph node) pN: pNO. Distant metastasis (pm): Could not be assessed Prognostic markers: See prior core biopsy 4x2, 14 DIAGNOSIS A. Sentinel lymph node, left axilla, resection: Single lymph node negative for metastatic ductal carcinoma. (0/1). B. Breast, left, simple mastectomy: Grade 2 invasive ductal carcinoma with nonextensive cribriform DIAGNOSIS DCIS. Second biopsy site containing residual solid DcIs Post-biopsy changes present at both biopsy sites. The nipple, deep margin of the mastectomy and overlying skin are free of involvement by tumor. M.D. (Electronic Signature) - End Of Report. ERD
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diff --git a/output/text/e82035a9-1b44-4a11-8630-2c9185382942.txt b/output/text/e82035a9-1b44-4a11-8630-2c9185382942.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4523202b757cafd8fdf9d3cd74b9d9ba387c6c96
--- /dev/null
+++ b/output/text/e82035a9-1b44-4a11-8630-2c9185382942.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+P.233 TSNOSIS: Vninel Lymph nooe #1. LEft, sentinel nOde Biop8y - WE LYMPH NODE, NO TUMOR IDENTIFIEO (0/1). ARt 2: sentinel Lymph node #2, Left, sentinel node BiOpsy -- One Lymph nOoe, nO tUmOr iDEnTIFieD (Q/1) Part 3: breast, Leet. segmental. mastectomy -- Inyasiye buctal carcinoma.  nOttingham grADe 2 (tuBal fOrmatiOn 3, nucleAr PLeOmOrpmiSm 2, mitoTic ActimTy 1, tOtAl. Score d out of 9). C.  INVASIVE TUMOR MEASURE8 2.5 CMIN LARGEST DIMENSION.E D.  DUctAL CArcinOmA In-SITU. nUcLEAR GrADe 2, SOLiD AND CRIBRIfORm TyPES PReSent In TWO Out of nineteen suides. E. LymphoVAscuLaR inVasiOn iS not IDentIFied. F.  RESECTION MARGINS ARE NEGATIVE FOR iNVASIVE CARCINOMA; INVASIVE CARCINOMA I8-0.4 CM From The nearest Lateral margin (slide 3e). G.  iNvasIve Carcinoma Is LocateD in The uppEr ouTer aNd LowEr OuTEr QuaDranTs.e inTrADUctal PapILLOMa WITH DUctAL EPiTHeLiAL hYpERpLASIA.E H.  InVASIVE TUMOR CELL3 ARE POSITIVE FOR ESTROGEN ANQ PROGESTERONE RECEPTORS AND  Negative for her-2 per pathology report p o. CASe SyNoPSIS:  SynopTiC - pRimAry Invasive CArcinoma Of Breast LAteraLIty: PROCEDURE: l.cf Segmenlal LOCATION: Upper ouler qiadrant Size Of tumoR: Lowot outar qudranl 1cs-0-3 Maxinum dImension Inivaaive component: 2.5 r.m MUlTIcEnTrIcITyAMUL TIFOCALITY OF InVASIvE FOCI: Carciioma, mfiPtatvy ouchl,wos 85oo/3 TUMOR TYPE (Invastve componont): NU Site: brsst, Nos Ductal adencarcinoma, NO3 c5o.9 3|13/n Js NOTTInGHAM SCORE: Nuclear grade. 2 Tubule formution: 3 Mhotlc activily score: 1 Total Nonirryhum score: G ANgiOLYmPhATiC INVASION: Nouingham grade (1. 2, 3) 2 Dermal Lymphatic invasiOn: No Not spplicahle CaLcifIcation: Yes. inallgnant zones Tumor type, in situ: Crihriform Solk SURGICAL mARGIns InVOLVED By InVASivE COmPONEnT:E DCIs admixcd with invasive carcinoma No Surg margins involVed by In situ component: Distarnro al invasive tumor lu uiosest margin: 4 mm Lymph nodes Positive: No Lymph nOdes exAmIneD: 0 methon(S) Of Lymph nODe exAminatiOn: 2 HE stain SENTINEL NODE METASTASIS: UUID: E8EA922D-A851-4D36-B70D-372DE9352548 NOn-neoPLAstic BreaSt Tissue: Papilloma No 'TcgA-Bh-A0De-01A-PR Redacted t stage pathologic: N stage, pathologic: pT2 M stage, pathologic. pNO Estrogen ReceptOrs: pMX PROGESTERONE RECEPTORS: pocitive HER2/NEU: poeilive zero or 1+ 58
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diff --git a/output/text/e82ed30b-6f29-445e-83d5-9b99d94ce9ee.txt b/output/text/e82ed30b-6f29-445e-83d5-9b99d94ce9ee.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9daac4f4444d78b3c09f0e5a3a051f944c0d22f6
--- /dev/null
+++ b/output/text/e82ed30b-6f29-445e-83d5-9b99d94ce9ee.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID: 57959509-A138-4131-BE87-9A77ED365702 TCGA-MI-A75H-01A-PR Redacted IcDo 3 817013 Site dliuer  SURGICAL PATHOLOGY Cq2.0 Ows)13 JI3 MEDICAL RECORD SURGICAL PATHOLOGY PATHQLOGY REPORT Laboratory: Accession Submitted by: SURGERY Date obtained: Specimen (Receive) A. PARTIAL SEGMENT (6) LIVER RESECTION-FRESH BRIEF CLINICAL HISTORY: PREOPERATIVE DIAGNOSIS: Hepatocellular Carcinoma OPERATIVE FINDINGS: POSTOPERATIVE DIAGNOSIS: Hepatocellular Carcinoma Surgeon/physician: PATHOLOGY REPORT Laboratory: Accession No. GROSS DESCRIPTION: The specimen consists of a 33.4 g, 8.0 x 3.9 x 2.9 cm, tan-brown,. irregular soft tissue grossly consistent with segment of liver. The capsule is tan-pink to yellow and smooth to nodular..  No gross evidence of mass is identified on the capsule.  The resection margin is tan-brown and scabrous with abundant metallic clips..  The resection margin is inked black, and the specimen is serially sectioned to. reveal a 2.2 x 2.0 x 2.0 cm, tan-yellow to white, iobulated, The gross findings are communicated to the surgeon for an. intraoperative gross consultation. The mass grossly abuts the overlying capsule. The remaining liver parenchyma is tan-brown and unremarkable. No. subsequent lesions are identified. Representative sections are submitted as follows: Al-A9- entire mass with overlying capsule and liver resection margin; Al0- uninvolved liver parenchyma away from mass. (Note: Representative portion is taken for tissue bank.) MICROSCOPIC EXAM DIAGNOSIS LIVER, SEGMENT 6, PARTIAL RESECTION  HEPATOCELLULAR CARCINOMA (SEE CANCER SUMMARY AND COMMENT)S - CirrhosIS Surgical Pathology Cancer Case Summary Based on AJcc/uIcc TNM, 7th edition - Specimen: liver Procedure: Partial hepatectomy, Minor hepatectomy Tumor Size: 2.2 x 2.0 x 2.0 cm Tumor Focality: Solitary Histologic Type: Hepatocellular carcinoma Histologic Grade: Tumor Extension: Tumor confined to liver - Margins:
+
+--- Page 2 ---
+- Parenchymal Margin: 0.2 cm. Lymph-Vascular Invasion: - Macroscopic Venous (Large Vessel) Invasion: not identified - Microscopic (Small Vessel) Invasion: Present - Perineural Invasion: not identified. Pathologic Staging (pTNM): - No nodes submitted or found. - Additional Pathologic Findings:. - CIRRHOSIS (see comment))  Clinical History (per cpRs chart): - HEPATITIS C AND CROHN'S DISEASE - ELEVATED LFTs AND AFP Comment: In the fibrosis scoring methods the unafected liver parenchyma scores Knodell 4/4, Metavir 4/4 and Ishak 6/6. concurs with the findings.. notified on at PATHOLOGIST Signed 2
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diff --git a/output/text/e8524ef7-341e-42ab-9c1f-946afab0d57a.txt b/output/text/e8524ef7-341e-42ab-9c1f-946afab0d57a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..83dcb5bbf8b578ff035f787833e02cded5f34bdc
--- /dev/null
+++ b/output/text/e8524ef7-341e-42ab-9c1f-946afab0d57a.txt
@@ -0,0 +1,21 @@
+
+--- Page 1 ---
+FIBROCYSTIC MARGINS CARCINOMA IS CARCINOMA IS IDENTIFIED. DCIS IS LOCATED IN NECROSIS. CRIBRIPORM TYPES Share), 1) DIAGNOSIS: Specimens Submitted: - NO CALCIFICATIONS ARE IDENTIFIED IN EITHER THE INVASIVE OR IN SITU THE INVASIVE CARCINOMA IS 0.2 CM FROM THE NEAREST (ANTERIOR AND DEEP)S BREAST, RIGHT AND SILICONE SP % INVASIVE Sentinel Sentinel IN node node  ** THE node Continued on next page **. THE INVASIVE  WITHOUT ATYPIA. CARCINOMA, level one UPPER OUTER LOCATED IN THE UPPER OUTER QUADRANT. THE COMPONENT . HISTOLOG right  right : METAPLASIA. MICROCALCIFICATIONS. ANDS ) IS ALSO IDENTIFIED SIOI  IN SITU OR INVASIVE CARCINOMA Hlap tissue : 4  M'op. REPORT PATH SOLID AND 1co-0 -3 earcimomr, vifilrsting duct, Nos 8.5ocf3 Site. brust nus C.50.4 j0j2a UUID:A54E82A4-D7C2-4A5C-A69C-C66976F0282F TCGA-AO-A12A-01A-PR Redacted
+
+--- Page 2 ---
+UF SPECIAL STAINS (EK, PK, HER-NEU) WILL BE REPORTED AS AN ADDENDUM. 2) LYMPH NODE, SENTINEL #1, LEVEL I. RIGHT AXILLA: EXCISION: - ONE BENIGN LYMPH NODE (C/1). DEEPER LEVEL RECUTS AND SPECIAL STAINS HAVE BEEN ORDERED. RESULTS WILL BE REPORTED IN AN ADDENDUM. 3) LYMPH NODE. SENTINEL #2, LEVEL I, RIGHT AXILLA; EXCISION: - ONE SENIGN LYMPH NODE (O/1). DEEPER LEVEL RECUTS AND SPECIAL STAINS HAVE BEEN ORDERED. THE RESULTS WILL BE REPORTED IN AN ADDENDUM. 4) LYMPH NODE, SENTINEL #3, LEVEL I, RIGHT AXILLA; EXCISION:  ONE SENIGN LYMPH NODE (O/1). DEEPER LEVEL RECUTS AND SPECIAL STAINS HAVE BEEN ORDERED. THE RESULTS WILL BE REPORTED IN AN ADDENDUM. 5) LYMPH NODE. SENTINEL #4. LEVEL I. RIGHT AXILLA; EXCISION: - ONE BENIGN LYMPH NODE (O/1). DEEPER LEVEL RECUTS AND SPECIAL STAINS HAVE BEEN ORDERED.S THE RESULTS WILL BE REPORTED IN AN ADDENOUM. 6) NON-SENTINEL TISSUE. RIGHT AXILLA; EXCISION: .TWO BENIGN LYMPH NODES O/2). 7) LYMPH NODES, SENTINEL #5, LEVEL I. RIGHT AXILLA: EXCISION: TWO BENIGN LYMPH NODES (O/2). DEEPER LEVEL RECUTS AND SPECIAL STAINS HAVE BEEN ORDERED. THE RESULTS WILL BE REPORTED IN AN ADDENDUM. 8) BREAST, RIGHT, ADDITIONAL SUPERIOR MASTECTOMY FLAP TISSUE; EXCISION:  BENIGN FIBROADIPOSE TISSUE AND SKELETAL MUSCLE. - NO RESIDUAL CARCINOMA SEEN. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. M/ Special studies: Result positive Special stain positive ER-C Comment negative PR-C HER2-C NEG CONT intensity of 1+ NEG-HER2 negative IMM RECUT AE1:AE3 NEG CONT positive IMM RECUT AE1:AE3 NEG CONT negative IMM RECUT AE1:AE3  NEG CONT PATH Continued on next page. REPORT
+
+--- Page 3 ---
+negative IMM RECUT AEI:AE3 NEG CONT negative IMM RECUT AEI:AE3 3 NEG CONT IMM RECUT Gross Description: 1) The specimen is received fresh, labeled, *Right breast and silicone implant". It consists of product of right mastectomy which measures 14.0 cm from superior to inferior, 1t.0 cm from medial to lataral, 5.0 cm from anterior to posterior. which measures 10.0 x 3.5 cm.. There is a skin ellipse with nipple arcolar complex. inked in black, superior-anterior tissue edge is inked in green, and the The nipple is erect. The posterior aspect is inferior-anterior tissue edge is inkcd in blue.. sectioned from the lateral to medial revealing a stellate vasculatcd mass in The specimen is serially. 0.2 cm from anterior tissue edge, 0.2 cm from the deep surgical margin. deep margin is easily movable over the tumor mass.. It is present identified which measures 7.0 x 7.0 x 0.3 cm.. A silicone implant is The surrounded by fibrous partially calcified capsule. It is intact. It is Suwary of Sections: M  nipple tumor  UOQ - upper outer guadrant LOQ - lower outer quadrant LIQ .  lower inner quadrant 2) The specimen is received fresh for frozen section, labelod *Sentinel node #l level ore right axillar.. measuring 1.0 x 0.5  0.1 cm. It consists of one firm brown-tan node. Bisected and entircly frozen. Sumcnary of Sections: Fsc - Sxozen section control. 3) node #2 level one right axilla". It consists of a 1.6 x 1.2 x 0.6 cm brown-tan lymph node bisected and entirely frozen. Summary of Sections: FSC - frozon section control PATH * Continued on next page ** REPORT
+
+--- Page 4 ---
+4) The specimen is received fresh for Irozen section. labeled -Sentinel node #3 level one righs axilla*. It consiscs of a 1.7 x 0.6 x 0.6 cm brown-tan node bisected and ertirely frozea. Summary of Sections:. Fsc - frozen section control. 5) The specimen is received in formalin, labeled *Sentinel node #4 level One right axilla". It consists of a portion of adipose tissue which measures 1.9 x 1.5 x 0.6 cm. which measures 1.5 x 1.0 x 0.4 cm. Examination reveals a pink-tan lymph node eatirely.  The lymph node is bisectod and submitted Summary of Sections: SN sentinel node 6) The specimen is received in formalin, labeled "Non-sentinel tissue. right axilla". It consists of three irregular shaped portions of yellow adipose which measures 0.6 x 2.5 cm in greatest dimension. The specimen is submittcd entirely in one cassette. Suamary of Sections: NS non-sentinel tissue. 7) The specimen is received in formalin, labeled -Sentinel node #5 level. one right axilla". It consists of pink-tan portion of soft tissue which. measures 0.7 x 0.4 x 0.3 cm. The specimen is submitted entirely.. Summary of Sections: SN  sentinel node 8) The specimen is received in formalin, labeled "Additional superior right mastectomy flap tissue". It consists of two unoriented flap portions of fibrofatty tissue which measure 5.5 x 2.0 x 0.6 cm and 4.5 x3.0 x 0.9 cm. Each piece has a cauterized aspect which is inked ia red. The opposing aspect is inked in green.. entirely. The specimen is serially sectioned and submitted Summary of Sections: U - undesignated PATH ** Continued on next page ** REPORT
+
+--- Page 5 ---
+Summary of Sections: Part 1: SP: Right breast and silicone implant 5 3lock Sect. Site  pCs 1 c d r 5 r LIQ LOQ UIQ Part 2: 1 SP: Sentinel node #1 level one right axilla. Block Sect. Site PCs Fsc 1 Part 3: SP: Sentinel node #2 level one right axilla Block Sect. site. PCs FSC 1 Part 4: SP: Sentinel node #3 level one right axilla. Block Sect. Site PCs FSC 1 Paxt 5: SP: Sentinel node #4 level one right axilla. Block Sect. Site * : pCs SN 1 Part 6: SP: Non-sentinel tissue right axilla Block Sect. Site 1 PCs NS 1 Part 7: SP: Sentinel node #5 level one right axilla. Block Sect. Site PCs SN 1 Part 8: SP: Additional superior right mastectomy flap tissue Block Sect. site PCs Procedures/Adderda: Addendum Date Ordered: : Date Complete: Status: Signed Out By: PATH ** Continued on next page * REPORT
+
+--- Page 6 ---
+Date Reported: Page 6 o 7 Addendum Diagrosis ADDENDUM SITE: SENTINEL LYMPH NODE, RIGHT AXILLA PART #3. METASTATIC CARCINOMA IN THE FORM OF MICROSCOPIC CLESTERS, MEASURING LESS THAN 2MM (MICROMETASTASIS). IS IDENTIFIED ON ADDITIONAL H&E STAINED SECTIONS AND CYTOKERATIN IMMUNOHISTOCHEMICAL STAINS. ADDITIONAL H&E STAINED SECTIONS AND IMMUNOHISTOCHEMICAL STAINS FOR CYTOKERATINS (AEI:AE3 AND CAM S.2) ON THE CTHER SENTINEL LYMPH NODE FROM PART #2,4,S,7 SHOW NO EVIDENCE OF METASTATIC TUMOR. Addendum Date Ordered: : Date Complete: Status:  Siqned Out Date Reported: By: Addendum Diagnosis ADDENDUM SITE:  RIGHT BREAST PART #1 ER: 9O% OF NUCLEAR STAINING NITH MODERATE INTENSITY. PR 90 OF NUCLEAR STAINING WITH STRONG INTENSITY HER2/NEU (HERCEPTEST) : NEGATIVE (STAINING INTENSITY OF 1+) Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 2) FROZEN SECTION DIAGNOSIS:  BENIGN LYMPH NODES. PATH ** Continued on next page * REPORT
+
+--- Page 7 ---
+PERMANENT DIAGNOSIS: SAME. 3)  FROZEN SECTION DIAGNOSIS: PERMANENT DIAGNOSIS: BENIGN LYMPH NODES.  SAME . 4) FROZEN SECTION DIAGNOSIS:  PERMANENT DIAGNOSIS: BENIGN LYMPH NODES. SAME. PATH # End of Report REPORT
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diff --git a/output/text/e85436a0-a822-44ba-90f4-819410d95e5b.txt b/output/text/e85436a0-a822-44ba-90f4-819410d95e5b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2fb75b29fcbae0807f6b1c2f2fe84b9d00b6fe12
--- /dev/null
+++ b/output/text/e85436a0-a822-44ba-90f4-819410d95e5b.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1cs-0-3 Cavcinomr, nfittrathy 1o5ulu,Nos 85s o/3 Sife : buuot Nvs c5o.9 be 8[18]   Final Diagnosis A. Breast, left, simple mastectomy: Infiltrating lobular carcinoma, Nottingham grade I (of III) [tubules 3/3, nuclei 1/3, mitoses 1/3; Nottingham score 5/9] is identified forming a mass (4.8 x 2.7 x 1.9 cm) located in the lower outer quadrant of the breast. Biopsy site changes are present. The tumor does not involve the nipple, overlying skin, or underlying chest wall. Lobular carcinoma in situ is also present. All surgical resection margins, including the deep margin, are negative for tumor (minimum tumor free margin, 0.3 cm, deep margin and 0.5 cm, superficial margin). With available surgical material, the AJCC staging is pT2NXMX (see comment). B. Breast, right, simple mastectomy: Benign nonproliferative breast parenchyma.. C. Lymph nodes, left axillary, lymphadenectomy: Multiple (14) lymph nodes are negative for tumor. D. Lymph nodes, left lowest axillary, lymphadenectomy: Fibroadipose tissue, negative for tumor. No lymphoid tissue identified.. UUID: E586771D-450A-49AD-AEBC-7FC056BFCDBE Redacted
\ No newline at end of file
diff --git a/output/text/e8583134-7529-4656-af68-db875b9f976c.txt b/output/text/e8583134-7529-4656-af68-db875b9f976c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0d815bd17a86ae72bf18f7c4ef2d28b088a6b7e0
--- /dev/null
+++ b/output/text/e8583134-7529-4656-af68-db875b9f976c.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+FINAL DIAGNOSIS: Part 1: Lymph nOde, LEft, Sentinel #1, BiOpsy -- METASTATIC CARCINOMA iNVOLVES ONE LYMPH NODE (1/1) (SLIDES 1FS); 1.5 MM MICROMETASTASIS Part 2: breast, Left, mastectomy, Simple -- A.  INVASIVE DUCTAL CARCINOMA. B.  3.0 Cm caRgest invasive tumor Dimension. C. NOTTINGHAM GRADE 3/3 (TUBULAR FORMATION 3/3, NUCLEAR PLEOMORPHISM 3/3, MITOTIC ACTIVITY 2/3; TOTAL SCORE 8/9).  DUCTAL CARCINOMA IN-SITU (DCIS), NUCLEAR GRADE 3, SOLiD, CRIBRIFORM, MICROPAPILLARY TYPES WITH MINIMAL COMEDO NECROSIS; DCIS iS PRESENT ADMIXED WITH AND AWAY FROM THE INVASIVE COMPONENT iN EIGHT OF THIRTEEN (8/13) SLIDES AND REPRESENTS 5% OF TOTAL TUMOR MASS. LYMPHOVASCULAR SPACE INVASION IS iDENTIFIED (SLiDE 2E). F. * NEGATIVE INKED SURGICAL RESECTION MARGINS; CLOSEST NEGATIVE MARGIN 0.7 CM FROM INNER/LOWER QUADRANT DEEP MARGIN.S  NIPPLE AND SKIN ARE NEGATIVE FOR TUMOR. H.  CALCIFICATIONS ARE ASSOCIATED WITH IN-SITU CARCINOMA, INVASIVE CARCINOMA, AND BENIGN BREAST PARENCHYMA. 1. FOCAL ATYPICAL LOBULAR HYPERPLASIA (SLiDE 2J). J. NON-NEOPLASTIC BREAST SHOWS FIBROCYSTIC CHANGES, APOCRINE METAPLASIA, DUCT ECTASIA, AND DUCT EPITHELiAL HYPERPLASiA. K.  BIOPSY SITE CHANGES. L.  SEVENTEEN AXILLARy LymPH NOnES AieA Jcs -0 -3 CASE SYNOPSIS: cartn`ona,mfiIt^atmg ductl, nos 8500j SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST LATERALITY: Sih: brenst, Nos Left c50.9 3/3/1 h PrOceDure:  Modified radical mastectomy LOCATION: Upper outer quadrant. Upper inner quadrant SIZE OF TUMOR:  Maximum dimension invasive component: 3.0 cm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: No TUMOR TYPE (invasive component): Ductal adenocarcinoma, NOS NOTTINGHAM SCORE: Nuclear grade: 3 Tubule formation: 3 Mitotic activity score: 2 Total Nottingham score: 8 UUID:880F3DC6-4342-4232-A04E-A128F1A8201D Nottingham grade (1, 2, 3): 3  TCgA-Bh-A0c7-01A-PR Redacted ANGIOLYMPHATIC INVASION: Yes DERMAL LYMPHATIC INVASION: No CALCIFICATION: Yes, benign zones Yes, malignant zones Tumor type, in situ: Cribriform, Solid SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No Distance of invasive tumor to closest margin: 0.7 mm SURG MARGINS INVOLVED BY IN SITU COMPONENT: No Distance of in situ disease to closest margin: 1.3 mm PAGET'S DISEASE OF NIPPLE:  No LyMPH NODES POSITIVE: 1 LYMPH NODES EXAMINED: 18 METHOD(S) OF LYMPH NODE EXAMINATION:  H/E stain, H/E levels SENTINEL NODE METASTASIS: Yes ONLY KERATIN POSITIVE CELLS ARE PRESENT: No SIZE OF NODAL METASTASES: Diameter of largest lymph node metastasis: 1.5 mm LYMPH NODE METASTASIS(-ES) WITH EXTRACAPSULAR EXTENSION: No  METASTASES TO IPSILATERAL iNTERNAL MAMMARY LYMPH NODE (IF APPLICABLE): No SKIN INVOLVED (ULCERATION): No NON-NEOPLASTIC BREAST TISSUE: FCD t Stage, pathologIc: pT2 N Stage, patholOgiC: pN1mi M STAgE, PAThOLOGIC: pMX ESTROGEN RECEPTORS: positive PROGESTERONE RECEPTORS: negative
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diff --git a/output/text/e868abb5-72e4-48c3-92a6-b77e1b66d308.txt b/output/text/e868abb5-72e4-48c3-92a6-b77e1b66d308.txt
new file mode 100644
index 0000000000000000000000000000000000000000..21fcd189e53ba2341ad8cee579c9d44fa7de2dc0
--- /dev/null
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+
+--- Page 1 ---
+UUID: 2649764C-9566-49DB-B8E9-B4886D8B763C8 TCGA-A7-A4SA-01A-PR Redacted Final Surgical Pathology Report. Procedure: Diagnosis A. Sentinel lymph node #1, biopsy: One lymph node with metastatic carcinoma (1/1). B. Breast, left, mastectomy: Invasive pleomorphic lobular carcinoma, size 2.2 cm in greatest dimension; negative margins of excision. C. Breast, left nipple core, biopsy: Negative for malignancy. D. Lymph nodes, left axilla, lymph node dissection: Nine negative lymph nodes (0/9). Microscopic Description: Invasive carcinoma: Histologic type: Lobular (E-cadherin negative). Histologic grade: 2 (pleomorphic lobular) Overali grade: 7/9 Architectural score: 3 Nuclear score: 3 (focally - the tumor consists of a mixture of conventional and pleomorphic lobular carcinoma, with nuclear grade ranging from 1-3) Mitotic score: Greatest dimension (pT2): 2.2 cm Specimen margins: Invasive carcinoma is 2 mm from the anterior margin, and there is lobular carcinoma in-situ (nuclear grade 1-2) focally 0.5 mm from the anterior margin. Carcinoma is 1 cm from the deep margin. Vessel invasion:  Not identified Ductal carcinoma in situ: Not identified Comments:  Prior biopsy site identified within the tumor Lymph nodes: Keratin staining performed on negative lymph node blocks to confirm the absence of carcinoma. Number of positive nodes of total: One of ten lymph nodes with metastatic carcinoma (1/10) Size of largest metastasis:. 7 mm Extracapsular extension (present/absent): Negative pN1a Prognostic markers: See previous core biopsy, Jcs-0-3 carcinoma, mfi1t/uHNg lvbulw nos Specimen A. Left axillary sentinel node #l, hot, blue 8520/3 C. Left nipple core Sits:brust,No5 tso,9 D. Left axillary contents clinical Information Left breast cancer Intraoperative Consultation A) Metastatic carcinoma. crs: Nipple, core biopsy: No evidence of invasive carcinoma.
+
+--- Page 2 ---
+Gross Description  Received unfixed for frozen section, labeled left axillary sentinel A. node #1, hot, blue , is a fat-replaced lymph node, 2.0 x 1.0 x 0.7 cm, bisected and frozen in two blocks. Received unfixed, labeled with the patient's name, medical record. number and "left breast - stitch at 12:0o." The specimen consists of a nipple sparing simple mastectomy oriented by a stitch at the 12:00  The deep surgical margin position. The specimen is 14 x 14 x 3.5 cm. On is painted black and anterior margin over tumor is painted green.. cut section at the 6:00 position there is a firm spiculated tan tumor A portion is submitted for. mass which measures 2.2 x 1.8 x 1.5 cm.. tissue procurement.  The tissue surrounding the mass contains dense. The mass comes within 4 mm of the anterior margin fibrocystic changes..  The remainder of the breast tissue and 1.5 cm of the deep margin. Representative sections. BLOCK consists of firm fibrofatty tissue. SUMMARy 1-3: Tumor mass with anterior margin, 4: Deep margin nearest tumor, 5, 6: Breast tissue immediately adjacent to the tumor mass, 7: Upper inner quadrant, 8: Lower inner quadrant, 9: Upper outer quadrant, 10: Lower outer quadrant C. Container c. is labeled with the patient's name, medical record  The specimen consists of a single piece number and "left nipple core". of soft yellow tissue measuring 0.5 x 0.5 x 0.3 cm. All submitted in D. Received fresh labeled "left axillary contents" is a 5.7 x 3.9 x 1.7 cm aggregate of soft, lobulated tan gold adipose tissue. Several. slightly rubbery tan-pink-red tissues in keeping with lymph nodes measuring up to 1.9 cm are recovered. The lymphoid tissues are entirely submitted.. nodes, 3 and 4 - one lymph node per cassette
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diff --git a/output/text/e869f045-e1ac-4a3a-947a-a87c836cf75d.txt b/output/text/e869f045-e1ac-4a3a-947a-a87c836cf75d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f91de40f2db01a3a1d0226395beba2233c81cbc8
--- /dev/null
+++ b/output/text/e869f045-e1ac-4a3a-947a-a87c836cf75d.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+5/23/n 1es-0 -3 caunna,ingltnatiNy duct,nos 85"o0f3 Site. brsot, 'nos c50.9 5723 ACC # 26 A) ADDITIONAL MARGIN OF MOST MEDIAL TUMOR, EXCISION: Benign breast tissue, no tumor present. (B)/LEFT BREAST, SEGMENTAL MASTECTOMY: MULTIFOCAL INVASIVE DUCTAL CARCINQMA WITH ASSOCIATED LYMPHOCYTIC INFILTRATE, HIGH NUCLEAR GRADE, NOTTINGHAM HISTOLOGIC GRADE 3. (SEE COMMENT) LARGEST FOCUS OF INVASIVE CARCINOMA MEASURES 1.2 CM IN GREATEST DIMENSION IN THE MEDiAL ASPECT OF THE SPECIMEN. MULTIPLE SATELLITE FOCI OF INVASIVE CARCINOMA ARE LATERAL TO THE MAIN FOCUS AND MEASURE 5 MM (X 2), 4 MM, 3 MM AND 1 MM. LYMPHOVASCULAR INVASION IDENTIFIED. DUCTAL CARCINOMA IN SITU (DCIS), HIGH GRADE, PREDOMINANTLY CRIBRIFORM AND CLINGING TYPES WITH CANCERIZATION OF LOBULES AND ASSOCIATED LYMPHOCYTIC INFILTRATE. DCIS EXTENDS IN AN APPARENT IRREGULAR DISTRIBUTION OVER A 4 CM AREA. DCIS EXTENDS TO LESS THAN 1 MM FROM THE ANTERIOR MARGIN, TO 1 MM FROM THE INFERIOR MARGIN, AND TO 2 MM FROM THE SUPERiOR AND POSTERIOR MARGINS INVASIVE CARCiNOMA EXTENDS TO 2 MM FROM THE ANTERIOR MARGIN. (SEE COMMENT) (C) ADDITIONAL CENTRAL ANTERIOR INFERIOR MARGIN, EXCISION: Benign breast tissue, no tumor present. (D) LEFT AXILLARY CONTENTS, DISSECTION: METASTATIC CARCINOMA IN ONE OF THIRTY.LYMPH NODES (1/30); METASTASIS MEASURES 7 MM; NO EXTRANODAL EXTENSION IDENTIFIED. (E) ADDITIONAL LEVEL I LEFT AXILLARY TISSUE, EXCISION: Two lymph nodes, no tumor present (0/2). Entire report and diagnosis completed by COMMENT Additional tissue was re-excised, and invasive carcinoma does not approach the final margins. However, I  with involvement of lobules is 1 mm from the final inferior margin and 2 mm from the final superior and posterior margins. Tumor marker studies will be performed and reported in an addendum. UUID:CA6B733A-6030-422C-9DE9-B9718C382FDC TCGA-GM-A2DF-01A-PR Redacted GROSS DESCRIPTION (A) ADDITIONAL MARGIN OF MOST MEDIAL TUMOR - Received is a piece of fibroadipose tissue (1.8 x 1.2 x 0.5 cm) with clips on the true margin. The true margin inked black. The specimen is serially sectioned and entirely submitted in A. (B) LEFT SEGMENTAL MASTECTOMY - A segmental mastectomy specimen (8.0 x 6.5 x 5.5 cm) with a short stitch at the superior aspect, long stitch at the lateral aspect, and multiple clips on the anterior aspect. The specimen is serially sliced from medial to lateral into 11 slices. A well-circumscribed tan-pink tumor 1.4 x 1.1 x 1.0 cm, with an associated biopsy clip is identified in
+
+--- Page 2 ---
+slice #3, which is 0.7 cm from the closest anterior margin. Multiple smaller nodules are identified Iateral to the main tumor. One of these is very close to the anterior margin in the central anterior inferior aspect of the specimen, and additional tissue is requested from this margin. INK CODE: Anterior - yellow, posterior - black, superior - blue, inferior - green, medial and lateral - red. SECTION CODE: B1, medial perpendicular margin; B2, tissue adjacent to tumor from slice #2 ; B3-B7, tumor and margins trom slice #3 (B3 and B4, tumor with anterior margin in area of clip; B5, inferior margin; B6, posterior margin; B7, superior margin); B8, tibrous tissue adjacent to the tumor from slice #4; 89, one small nodule, 1.2 cm from superior margin and 1.8 from anterior margin of slice #4; B10, one small nodule 1.0 cm trom anterior margin and 1.2 cm from superior margin of slice #5; B11, one small nodule, 1.5 cm from anterior margin, 2.0 cm from superior margin ot slice #5; B12, B13, one small nodule, 0.1 cm from anterior margin and 1.2 cm from inferior margin of slices #6 and #7; B14, one small nodule 0.4 cm from posterior margin and 1.5 cm from inferior margin of slice #4; B15-B18, remainder of margins of slice #4, entirely. submitted (B15, anterior margin; B16, superior margin; B17, posterior margin; B18, inferior margin); B19, representative section from slice #8; B20, lateral perpendicular margin. (C) ADDITIONAL CENTRAL ANTERIOR INFERIOR MARGIN, LEFT BREAST - A portion of tibroadipose tissue (2.0 x 1.3 x 0.5 cm) with clips on the true margin. The true marain is inked black. The specimen is serially sectioned and entirely submitted in C1-C2. (D) LEFT AXILLARY CONTENTS - Adipose tissue (11.0 x 7.5 x 3.0 cm). Multiple lymph nodes are identified ranging from 0.2 x 0.2 x 0.2 cm to 2.5 x 1.5 x 0.8 cm. SECTION CODE: D1-D3, each containing six lymph nodes; D4, four lyrmph nodes; D5, tour lymph nodes; D6, one lymph node, trisected; D7, one lymph node, serially sectioned: D8. one lymph node, serially sectioned; D9 and D10, one lymph node, serially sectioned. (E) ADDITIONAL LEVEL 1 LEFT AXILLARY TISSUE - Two lymph nodes (0.2 x 0.2 x 0.2 cm and 0.8 x 0.4 x 0.4 cm), entirely submitted. SECTION CODE: E1, one lymph node; E2, one lymph node, trisected. CLINICAL HISTORY Left breast cancer. SNOMED CODES T-04050, M-85003, M-85002 T-C4710, M-85006 "Some tests reported here may have been developed and norfarmance characteristics. These tests have not been determined by specifically cleared or approved by the U.S. Food and Drug Aaministration." Released by: Start of ADDENDUM #1 ADDENDUM Addendum completed by This report is issued to give immunohistochemistry results.
+
+--- Page 3 ---
+Immunohistochemical staining is performed on a representative tormalin-tixed, paraffin- embedded section of INVASIVE DUCTAL CARCINOMA, left breast, block B3. % POSITIVE SCORE MARKER RESULTS  Negative 0 % n/A Estrogen Receptor Negative < 1 % N/A Progesterone Receptor HER-2/neu Negative Focal 1+ overexpression Due to the above HER-2/neu immunohistochemical staining result, gene copy level (heR-2/neu: cEp17 signal ratio) will be evaluated by FIsH and'a separate report will be issued. FOOTNOTE Estrogen receptor was assessed by immunohistochemistry using antibody 6F11 ( Progesterone receptor was assessed by immunohistochemistry using antibody PgR1294( HER-2/neu was assessed by immunohistochemistry using antibody AB8 (l Released by: Start of ADDENDUM #2 ADDENDUM #2 This moditied report is being issued to report the results of HER-2/neu FISH Addendum completed by SPECIMEN SOURCE Left breast  SUMMARY Tissue section of the invasive carcinoma B3 was evaluated for HER-2/neu gene amplification by interphase fluorescence in situ hybridization technique using the " HER-2/neu DNA Probe Kit (LSI HER-2/neu !CEP17 Slide adequacy is satisfactory. Sixty tumor nuclei were counted and showed an average of 1.57 copies ot LSI HER-2/neu gene per nucleus and an average of 1.40 copies ot CEP17 per nucleus.
+
+--- Page 4 ---
+I with this batch are Negative and positive controls (established by appropriate. Two representative images have been archived. INTERPRETATION The tumor cells demonstrated no amplification of the HER-2/neu gene copy levels (HER-2/neu. CEP17 signal ratio: 1.12 ) The following guideline has been established for HER-2/neu testing:. Normal HER-2/neu levels: < 1.80; equivocal HER-2/neu levels: 1.80 -- 2.20; amplified HER-2/neu levels: > 2.20 (Ret: Arch Patholo Lab Med. 2007; 131:18-43) NOTES The LSI HER-2/neu probe is specitic for the HER-2/neu gene Locus (17q 11.2-q12) and the CEP 17 DNA probe is specitic for the alpha satellite DNA sequence at the centromeric region of Chromosome 17 (17 p11.1 -q11.2). This test has been cleared and approved tor specific uses by the U.S. Food and Drug. Administration. Its system is operating within the performance specifications stated in the product. insert. Released by: .--EnD OF REPORt---
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diff --git a/output/text/e8bde9ed-7bae-48bd-8dab-0ec3d990bd28.txt b/output/text/e8bde9ed-7bae-48bd-8dab-0ec3d990bd28.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d2fd133d192eec4ba675162d7a7b1c97be481687
--- /dev/null
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+
+--- Page 1 ---
+FINAL DIAGNOSIS TERMINAL ILEUM AND RIGHT COLON, RIGHT HEMI-COLECTOMY - A.INVASIVE MODERATELY DIFEERENTIATED ADENOCARCINOMA (5.5 CM) OF CECUM. B. ADENOCARCINOMAINVADES THROUGH MUSCULARIS PROPRIA TO SUBSEROSAL ADIPOSE TISSUE. PROXIMAL, DISTAL,ANDRADIALMARGINS FREE OF CARCINOMA. C. D.  NO ANGIOLYMPHATIC INVASION PRESENT. E. NO PERINEURALINVASION PRESENT. F. TWENTY-FIVE BENIGN PERICOLONIC LYMPH NODES (O/25/. TCGA-AZ-4315 G. PATHOLOGIC TUMOR STAGE pT3a, N0, MX. H. TERMINAL ILEUM WITHNO SIGNIEICANT ABNORMALITY. 1. APPENDIX WITH NO SIGNIFICANTABNORMALITY. CASE syNOpSiS: SYNOPTIC DATA - PRIMARY COLONARECTAL, APPENDIX TUMORS SPECIMEN TYPE: Right hemicolectomy. SPECIMEN LENGTH: 24.cm TUMOR SITE: :Cecum TUMOR CONFIGURATION: Exophytic (polypoid) TUMOR SIZE: Greatest dimension: 5.5 cm. Additional dimensions: 4.0 X 1.3 cm INTACTNESS OF MESORECTUM: Not applicable HISTOLOGIC TYPE: Adenocarcinoma HISTOLOGIC GRADE: Low-grade (well to moderately differentiated) PATHOLOGIC STAGiNG (pTNm): pT3a/b pN0 Number of nodes exarmined: 25 Number of nodes involved: 0 pMX MARGINS: Proximal margin uninvolved by invasive carcinoma Distal margin uninvoived by invasive carcinoma Circumferential (radial) margin - Not applicable Mesenteric margin uninvolved by invasive carcinoma ANGIOLYMPHATIC INVASION: Absent PERINEURAL INVASION:S Absent TUMOR BORDER CONFIGURATION: Infiltrating TUMORAL LYMPHOCYTIC RESPONSE: Mild to moderate
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diff --git a/output/text/e8f83ee7-1020-4b76-9187-fadbeb99f9bb.txt b/output/text/e8f83ee7-1020-4b76-9187-fadbeb99f9bb.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5bb83d09b10b2a7a85ab85e2426656c114f9f91d
--- /dev/null
+++ b/output/text/e8f83ee7-1020-4b76-9187-fadbeb99f9bb.txt
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+
+--- Page 1 ---
+Department of Pathology Page 1 of 3 UUID: 2C7A9333-9CCF-4E1E-A3DC-BE9ED78858B3 REPORT Tel: TCGA-VD-A8KK-01A-PR Redacted Clinical Consultant & Location Sex Unit Na This Copy For: IcD-0-3 SPECIMEN 3 Left (enucleated) eye 87$4|3 CLINICAL DETAILS Sit:DChosid cb9.3 Left choroidal melanoma. (l): ? orbital invasion. Qt J1/17/14 See diagram.. 19.5 x 17.1 x (10.9)mm. 40t SRF. MACROSCOPIC DESCRIPTION A fresh, intact left globe. Dimensions: Axial 26mm, Horizontal 24.5mm, Vertical 25mm Cornea: Horizontal ll.6mm, Vertical llmm Optic nerve Length 7mm, Diameter 4mm. On trans-illumination, a large shadow is seen over almost all medial half of the globe. Plane of section: horizontal Intraocular description: On opening, a large solitary pigmented choroidal mass is seen associated with probable focal underlying extrascleral extension. Tumour size. LBD 17.5mm, Height 12.6mm MICROSCOPY Sections show a partially pigmented choroidal melanoma consisting predominantly of spindle cells. Tumour cells express Melan-A and HSp 27 (score 2). There are approximately 7 mitotic figures in 40 high power fields. closed loops are focally present. The lymphocytic infiltrate within the tumour is minimal. Scattered macrophages are present. Tumour necrosis is not seen. Bruch'g membrane Reported: Pathologist: Electronically Verified:.
+
+--- Page 2 ---
+Department of Pathology Dage 2 of 3 HISTOPATHOLOGY REPORT Tel: Surname Lab No Cllnical Consultant & Location Forename(s)  DOB/Age Sex Unit No  Request Date This Copy For: appears breached in the sections examined. There is no tumour extension through optic nerve or vortex veins examined. Tumour, however, infiltrates through the sclera emerging on scleral surface and loosely attached episcleral tissue. Therefore completeness of excision may not be guaranteed. Elsewhere, the cornea shows no significant abnormality. The anterior chamber angles are open and the anterior chamber is deep. The iris shows no significant abnormality but the ciliary body appears atrophic with hyalinisation of  ciliary processes. The lens shows glassy appearance. Retina overlying the tumour is slightly atrophic.. DIAGNOSIS Left eye, enucleation: Choroidal melanoma of predominantly spindle cell type with extrascleral infiltration. SUMMARY SPECIMEN 2= Eye TUMOUR PRESENT Yes TUMOUR TYPE 1= Melanoma CELL TYPE 2= Spindle B 2= Closed loops CT LOOPS NECROSIS No PIGMENTATION Yes LYMPHOCYTIC INFILTRATION No MITOTIC FREQUENCY 7 /40 HPF DIFFUSE MELANOMA No SPREAD 3- Trans-scleral CLEARANCE 1- Inadequate HSP-27 POSITIVITY 2= 21-70% LARGE DIAMETER 17.5 mm Reported: Pathologist: Electronically Verifled:. Criterl HPAsc
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diff --git a/output/text/e8ff172a-6bc0-4142-aef0-c050422dae9b.txt b/output/text/e8ff172a-6bc0-4142-aef0-c050422dae9b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e26ad7541bc4b4220a5c25c361c2347e2e91d2c3
--- /dev/null
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@@ -0,0 +1,21 @@
+
+--- Page 1 ---
+UUID:FF69B05C-B041-4CBA-A481-66AB2510A4AC TCGA-GU-AATO-01A-PR Redacted Results BIOPSY OR SURGICAL SPECIMEN (Orde) Patient Information Patient Name MRN Sex DOB Result Information Status Provider Status Edited Reviewed Entry Date Component Results Component Lab Surgical Pathology IdO3 Patient Name Site YBlsdobr wal,NoS C.b79 Med Rec #: Accession #: J 1|80|i4 FINAL PATHOLOGICAL DIAGNOSIS A. Left distal ureter, radical cystoprostatectomy: - Unremarkable urothelium; no high grade dysplasla or carcinoma identified. - Frozen section diagnosis Is confirmed B. Right distal ureter, radical cystoprostatectomy: - Unremarkable urothellum; no high grade dysplasia or carcinoma Identified - Frozen section diagnosis is confirmed C. Bladder and prostate, radical cystoprostatectomy: Asv Tss, sguammrdiffrnhchior - Invasive urothellal carcinoma with squamous differentiation, high grade i0-50  - Tumor invades perivesical tissue macroscopicaly (pT3b) - All surgical resection margins free of tumor - Prostate with benign prostatic hyperplasia; no invasive carcinoma identified - See CAP template below for full report - See comment D. Right lliac lymph nodes, lymph node dissection: - Five benign lymph nodes identified, all negative for metastatic carcinoma. (0/5) E. Right obturator lymph nodes, lymph node dissection: - Three benign lymph nodes Identified, all negative for metastatic carcinoma. (0/3) F. Leftiliac lymph nodes, lymph node dissection: - Three benign iymph nodes identified, all negative for metastatic carcinoma. (0/3) G. Left obturator lymph nodes, lymph node dissection:. - Ten benign ymph nodes identified, all negative for metastatic carcinoma. (0/10) CAP Cancer Template Specimen: Page 1 of 7
+
+--- Page 2 ---
+Bladder Other (specify): Prostate Procedure: Radical cystoprostatectomy Tumor Site: Left lateral wall Anterior wall Posterior wall Right ureteral orifice Tumor Size: Greatest dimenslon: 4.5 cm. Histologic Type:  Urothelial (transitional cell) carcinoma with,squamous differentiation Associated Epithelial Lesions: None identified Histologic Grade: Urothellal Carcinoma (WHO 2004/ISUP):  High-grade Tumor Configuration: Solid/nodule Flat Ulcerated Mlcroscopic Tumor Extension: Invades perivesical tissue macroscopically (extravesical mass) Margins: Margins uninvolved by invasive carcinoma Distance of invasive carcinoma from closest margin: 0.5 mm. Specify margin: Posterior soft tissue margin Lymph-Vascular Invasion: Indeterminate Pathologic Staging (pTNM): TNM Descriptors:  m (multiple primary tumors) Primary Tumor (pT): pT3b: Macroscopically (extravesicular mass) Regional Lymph Nodes (pN): pNO:No lymph node metastasis. Specify: Number examined: 21 Number involved (any size): 0 Distant Metastasis (pM): Not applicable Additional Pathologic Findings: Urothelial dysplasia Inflammation/regenerative changes Page 2 of 7
+
+--- Page 3 ---
+Ancillary Studies:  None performed at this time; blocks C13 and C14 will be held for future studies. if necessary. The above pathology diagnosis incorporates data elements as outlined in the CAP Cancer Protocols and Checklists which are based on the AJCc/UiCC TNM, 7th. edition. DIAGNOSIS COMMENT Selected slides were reviewed at the ont and tne aiagnoses represent a consensus opinion. ***Electronically Signed Out By CLINICAL HISTORY Bladder tumor  Radical cystectomy/ prostatectomy with lleal conduit SPECIMEN(S) RECEIVED A: Left distal ureter B: Right distal ureter C: Bladder and prostate D: Right iliac lymph nodes E: Right obturator lymph nodes F: Left iliac lymph nodes G: Left obturator lymph nodes GROSS DESCRIPTION Specimen A is received fresh for frozen section labeled with the patient's name and designated "left distal ureter". The specimen consists of a segment of ureter measuring 0.5 cm in diameter x 0.3 cm in length. Section key: A1 specimen is completely submitted for frozen section Speclmen B is received fresh for frozen section labeled with the patient's name and designated "right distal ureter". The specimen consists of a segment of. ureter measuring 0.4 cm in diameter x 0.3 cm in length. Section key:  B1 specimen is completely submitted for frozen section Specimen C Type of specimen: Urinary bladder, ureter stumps, prostate, seminal vesicles The patient's name and case number on the specimen container match the accompanying paperwork and cassettes. Procedure: Radical cystoprostatectomy Fixative: Received fresh and later placed in formalin Dimensions: Bladder: Superior to inferior 7.5 cm, right to left 6.0 cm, anterior to posterior 3.5 cm Right ureter stump: 1.0 cm in length and 0.5 cm in diameter; left 2.5 cm in length and 0.5 cm in diameter Prostate: Apex to base 3.8 cm, anterior to posterior 3.2 cm, right to left 5.0. cm Description of findings: Page 3 of 7
+
+--- Page 4 ---
+Tumor: Three distinct separate tumors are identified. The largest tumor occupies the left lateral wall and extends to include portions of both the. anterior and posterior wall. In some areas, the tumor appears to abut the inked posterior bladder surface. This tumor measures 4.5 x 3.6 cm. The central portlon of the tumor is rough, hemorrhagic, and somewhat shaggy and has a somewhat necrotic appearance. The necrosis involves 80% of the surface of the tumor. There are tan-gray, nodular, vlable areas at the peripheral margin of the tumor. On section, this tumor can be seen to deeply invade the bladder wall  and appears to have extended through the full thickness to invoive the adjacent periveslcular adipose tissue. The second tumor occuples a portion of the posterior wall and extends laterally to surround the right ureteral orifice. This tumor measures 2.5 x 2.0 cm. The tumor is largely exophytic extending 0.9 cm above the lining of the bladder wall. The third tumor occuples a portion of the Inferlor anterior bladder wall and measures 1.7 x 1.5 cim and rises 0.6 cm above the lining of the bladder wall. The lumen of the bladder contains a large volume of form friable blood clot. The clot measures 7.0 x 7.0 x 2.5 cm. Uninvoived mucosa: The invoived mucosa has a norma! tan-gray appearance with no additional lesions noted. Sectioning through the prostate reveals a norma! tan-gray, lobulated, spongy cut surface.. Prostate, seminal vesicles and vasa deferentia:. Ink code: Anterior: blue Posterior: black Right side: orange Left side: blue Section key: C1 en face urethral resection margins. C2 largest tumor of left lateral wall, anterior surface C3 C8 largest tumor of left laterat wall and posterior surface C9, C10 second tumor of right lateral wall C11, C12 third tumor anteror wall. C13 left ureteral orifice C14 right ureteral orifice C15 right lateral wall C16 section of dome C17 C19 right prostate submitted distal to proximal C20 C22 left prostate submitted distal to proximal C23 right seminal vesicle and vas deferens. C24 teft seminal vesicle and vas deferens Specimen D is received in formalin labeled with the patlent's name and designated "right ilac lymph node". The specimen consists of an aggregate of yellow, fatty tissue measuring 5.0 x 4.3 x 2.5 cm. Multiple lymph nodes are identified ranging in size from 0.5 cm up to 2.1 cm in greatest dimension. Section key: The lymph nodes are entirely submltted as follows: D1, D2 largest lymph node trisected D3 two lymph nodes, bisected, one marked with ink  D4 two lymph nodes, bisected, one marked with ink Specimen E is received In formalin labeled with the patient's name and designated "right obturator lymph node". The specimen consists of an aggregate of yellow, fatty tissue measuring 5.5 x 3.8 x 2.0 cm. Three lymph nodes are identified ranging from 0.8 cm up to 3.5 cm in greatest dimension. Section key: The lymph nodes are entirely submitted as follows: E1 E3 largest lymph node trisected. E4, E5 one lymph node, bisected. E6 one single lymph node Specimen F is recelved in formalin labeled with the patient's name and designated *left iliac lymph node". The specimen consists of an aggregate of yellow, fatty tissue measuring 3.5 x 2.5 x 1.5 cm. Three lymph nodes are Page 4 of 7
+
+--- Page 5 ---
+identified ranging in size from 0.5 cm up to 1.5 cm in greatest dimension. Section key: F1 lymph nodes are completely submitted. Specimen G is received in formalin labeled with the patient's name and designated "left obturator lymph node". The specimen consists of an aggregate of yellow, fatty tissue measuring 4.5  4.0 x 2.3 cm. Multiple lymph nodes are identified ranging from 0.2 cm up to 3.0 cm in greatest dimension. Section key: Lymph nodes are completely submitted as follows: G1, G2 largest lymph nods bisected G3 two lymph nodes, bisected, one marked with blue ink G4, G5 muitiple single lymph nodes MICROSCOPIC DESCRIPTION The stain quality is acceptable. A-G. The microscopic findings are reflected In the dlagnoses rendered. INTRAOPERATIVE CONSULT DIAGNOSIS Time in: , Time out: AFS1, Left distal ureter: "Negative for malignancy". BFS1, Right distal ureter: "Negative for malignancy". Conveyed to by on  Interpretation performed at: Results Anatomic Pathology Report - Scan on Result History BIOPSY OR SURGICAL SPECIMEN -Order Result History Report, Revlewed by List Transcription Type ID Author Anatomic Pathology Report Signed by Document Text Display only: Transcription ! Collection Information Date and Time Accession # Lab Information Page 5 of 7
+
+--- Page 6 ---
+Status: This order is currently not shared In Order BIOPSY OR SURGICAL SPECIMEN Patlent Information Patient Name MRN Sex DOB Visit Information Date Time Department  Pravider Urology Admission Information. Attending Provider Admitting Provider  Admission Type Admission Date/TIme Discharge Date Hospital Service Auth/Cert Status Service Area Unit Room/Bed Admission Status Unknown Status (No Confirmation Status) Date and Time. Ordering Authorizing Department Urology Order Order Name Code Order Number BIOPSY OR SURGICAL SPECIMEN Discharge Information Discharge Provider Date/Time Disposition Destination (none) (none) (none) (none) Order Proyiders Authorizing Provider Encounter Provider Results Anatomic Pathology Report-Scan Collection Information Date and Time Accession # Priority and Order Details. Page 6 of 7
+
+--- Page 7 ---
+ Priority Class  Routine
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diff --git a/output/text/e93655b9-9cec-4c0e-a976-f8d800ab0532.txt b/output/text/e93655b9-9cec-4c0e-a976-f8d800ab0532.txt
new file mode 100644
index 0000000000000000000000000000000000000000..94612b1029d964bfc084d91958233e3e4572b898
--- /dev/null
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+
+--- Page 1 ---
+IcDo 3 curcnome) p0speQ0ssy reraQ eeQQ 836Of3 Site:Kidneey NE5 Cb4:9 UUID:7F7348FB-2484-4E77-83F2-B26C72CF6F3D lS o|i3114 TCGA-5P-A9KH-01A-PR Redacted 3.8 cm maximum dimension, moderately differentiated Papillary renal Cell Carcinoma. Notes glomerulosclerosis, interstitial nephritis and massive arteriosclerosis. Resection margins are tumor free. pTNM classification (edition 2002) Stage: pT1a, pNX, pMX Grade: GII Latrali hy
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diff --git a/output/text/e93bc491-e910-4a63-8243-c0a036557f34.txt b/output/text/e93bc491-e910-4a63-8243-c0a036557f34.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c7d08bda23cdf50dc7f0db06d1761d5b14eadb36
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+ UUID:C3243207-2190-4435-9AA9-39E38913E316 TCGA-GM-A2DH-01A-PR Redacted EPORT - REVieW ADDENDUM SECTION ****** DIAGNOSIS (A) RIGHT AXILLARY SENTiNEL LYMPH NODE #1, BIOPSY: SINGLE KERATIN-POSITIVE CELL SUSPICIOUS FOR iSOLATED TUMOR CELL IN ONE LYMPH NODE. (SEES COMMENT) (B) RIGHT AXILLARY SENTiNEL LYMPH NODE #2, BIOPSY: One lymph node, no tumor present (0/1).. (C) RIGHT BREAST, TOTAL mASTeCTOMY: iNVASIVE DUCTAL CARCINOMA WITH ASSOCIATED MILD LYMPHOCYTIC INFILTRATE, HIGH NUCLEAR GRADE  NOTTINGHAM HISTOLOGIC GRADE 3. (SEE COMMENT) INVASIVE TUMOR IS LOCATED IN THE UPPER OUTER QUADRANT AND MEASURES 1.5 CM IN GREATEST DIMENSION. FEW ADJACENT DUCTS WITH DUCTAL CARCINOMA iN SITU (DCIS), HIGH NUCLEAR GRADE, SOLID AND CRIBRIFORM TYPES WITH FOCAL COMEDONECROSIS, ASSOCIATED MICROCALCIFICATIONS, AND CANCERIZATION OF LOBULES. Columnar cell hyperplasia with associated calcifications also adjacent to tumor.. SINGE FOCUS OF INTRALYMPHATIC TUMOR. (SEE COMMENT) Tumor does not approach surgical margins.. Remaining breast tissue with mild tibrocystic change. Entire report and diagnosis completed by COMMENT  No tumor cells are identitied on the H&E stains of the sentinel lymph nodes. Immunostains for keratin were performed on each  the sentinel nodes (A1-A2, B1-B2), and a single keratin-positive cell suspicious tor an isolated tumor cell is present on one of the keratin stains trom sentinel node #1 (A2). A single cluster of tumor cells is noted within a dilated lymphatic channel next to the tumor. Because the channel is quite dilated and only a single focus is identified, it is unclear whether this represents true peritumoral lymphovascular invasion or displacement artifact '. Because on!y 5%. Tumor marker studies including FiSH for HER2 gene copy level were reported previously (see staining for estrogen receptor was reported, hormone receptor staining will be repeated on this specimen and reported in an addendum. icD-o-3 carcinoma,du<tcJ,in F 1tah nq 8S0oJ3 GROSS DESCRIPTION IZ RP (A) RIGHT AXILLARY SENTINEL LYMPH NODE #1, IN VIVO 195, EX VIVO 181 - A 1.5 x 1.0 x 0.6 cm possible lymph node, serially sectioned and submitted entirely for frozen section in A1, A2.. *FS/DX: NO TUMOR IDENTIFIED. (B) RIGHT AXILLARY SENT!NEL LYMPH NODE #2, IN VIVO 40, EX VlVO 28 - A 1.6 x 1.5 x 0.9 cm possible lymph node, serially sectioned and submitted entirely in B1, 82. *FS/DX: NO TUMOR IDENTIFIED. RIGHT TOTAL MASTECTOMY - A right total mastectomy specimen (22.0 x 16.0 x 4.5 cm) with attached skin ellipse (10.0 x 5.2 x 0.5 cm). The skin ellipse contains an unremarkable nipple (1.0 cm). The specimen is sectioned trom lateral to medial into ten slices with the nipple in slices 7 and 8. An irregular (1.5 x 1.5 x 1.2 cm) solid white, gritty mass is identified in slice 6, located 2.5 cm from the deep margin, 5.2 cm trom the inferior margin, 5.5 cm from the superior margin, 5.5 cm from the skin, 6.5 cm tfrom the lateral margin, and 6.0 cm m the medial margin. The rest of the breast parenchyma is grossly unremarkable.. INK CODE: Blue - superior; orange - inferior; black - deep. SECTiON CODE: C1, superior margin; C2, interior margin; C3, deep margin; C4, medial margin; C5, lateral margin; C6, skin closest to tumor; C7, base of nipple; C8, cross sections of tip of nipple; C9 and C10, tumor; C11, breast tissue deep to tumor;
+
+--- Page 2 ---
+C12, breast tissue medial to tumor; C13, breast tissue lateral to tumor; C14, breast tissue inferior to tumor; C15, breast tissue superior to tumor; C16, C17, representative sections from upper outer quadrant; C18, C19, representative sections of lower outer quadrant; C20, C21, representative sections of upper inner quadrant; C22, C23, representative sections of lower inner quadrant; C24, breast tissue anterior to tumor. : CLINICAL HISTORY Carcinoma of right breast.. SNOMED CODES T-04050, M-85002, M-85003, T-C4714, M-85017 "Some tests reported here may have been developed and performance characteristics determined by These tests have not been specifically cleared or approved by the U.S. Food and Drug Administration." Released by: Start of ADDENDUM ADDENDUM Addendum comnlated hv. This report is issued to give immunohistochemistry results. Immunohistochemical staining is performed on a representative tormalin-fixed, paraffin-embedded section of INVASivE DUCTAL CARCiNOMA, right breast, block C9. MARKER RESULTS % POSITIVE Estrogen Receptor Low Positive (1-9%) 5 % Progesterone Receptor Negative 0 % Ki-67 High (>35%) approx. 50 % COMMENT See : for HER2 immunostaining and FISH results. FOOTNOTE Estrogen receptor was assessed by immunohistochemistry using antibody 6F11 Progesterone receptor was assessed by immunohistochemistry using antibody PgR1294 Ki-67 was assessed by immunohistochemistry using antibody MIB1 Released by:
+
+--- Page 3 ---
+-..-EnD OF RepORt-
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diff --git a/output/text/e96a9427-dc11-43c2-af03-e27d7c5610f8.txt b/output/text/e96a9427-dc11-43c2-af03-e27d7c5610f8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1b4f717934754d6ecc3465bc33ababd9c389fa6c
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+
+--- Page 1 ---
+iCs-0-3 # 121/ SURGICAL PATHOLOGY REPORT Name: Lab No.: Sex: F Date Collected: Age: Date Received: Doctor: M.R. No.: Room No: Account No: CLINICAL HISTORY: PREOPERATIVE DIAGNOSIS: LEFT BREAST CA POSTOPERATIVE DIAGNOSIS: LEFT BREAST CA OPERATION: LEFT SIMPLE MASTECTOMY, SENTINEL LYMPH NODE BIOPSY, F.S. SPECIMENS: A. LEFT SENTINEL LYMPH NODE #1, F.S B. LEFT SENTINEL LYMPH NODE #2, F.S C. SENTINEL LYMPH NODE #3, F.S. D. LEFT BREAST SIMPLE MASTECTOMY FROZEN SECTION DIAGNOSIS: A. LEFT SENTINEL LYMPH NODE #1 - NUMEROUS HISTIOCYTES WITH ATYPICAL CELLS. DEFER FOR PERMANENT SECTION. B. LEFT SENTINEL LYMPH NODE #2 - ONE NEGATIVE LYMPH NODE (0/1). UUID: 8E6902A6-A673-46CC-9AEB-3A71EF11099F TCGA-A2-A0SY-01A-PR Redacted C. SENTINEL LYMPH NODE #3 - ONE NEGATIVE LYMPH NODE (0/1). FINAL DIAGNOSIS: A. LEFT SENTINEL LYMPH NODE #1 - POSITIVE FOR METASTATIC CARCINOMA (1/1); THE TUMOR INVOLVES THREE-FOURTHS OF THE NODE WHICH MEASURES .6 CM. IN DIAMETER, NO PERICAPSULAR SOFT TISSUE EXTENSION. B. LEFT SENTINEL LYMPH NODE #2 - ONE REACTIVE LYMPH NODE (0/1).
+
+--- Page 2 ---
+Page 2 Name Lab No.: C. SENTINEL LYMPH NODE #3 -- ONE REACTIVE LYMPH NODE (0/1) D. LEFT BREAST MASTECTOMY -- INVASIVE LOBULAR CARCINOMA (7 CM.). TUMORAL CALCIFICATION/NECROSIS: NONE IDENTIFIED. DCIS/LCIS: NONE IDENTIFIED. SURGICAL MARGINS/NIPPLE, SKIN AND AREOLA: UNINVOLVED. NON-NEOPLASTIC BREAST: FIBROCYSTIC CHANGES TO INCLUDE DUCTAL EPITHELIAL HYPERPLASIA. PTNM CLASSIFICATION: T3 N1 MX; STAGE IIIA. COMMENT: The multiple sections from the tumor reveal patchy areas of tumor infiltration extending up to lactiferous ducts. In addition, the tumor cells also display unfavorable nuclear features in many areas. The ER, PR and Her-2/neu have been performed on the previous biopsy The PanKeratin Immunostain is performed on specimens A, B and C. GROSS: A. The container is received fresh unfixed label:. 3ft sentinel lymph node #1 for frozen section'. The specimen consists of an ovoid mass of pink-tan soft rubbery. tissue mixed with fattv tissue measuring 0.6 cm. in greatest dimension. Frozen section is. obtained by The entire specimen including frozen section in one block. B. The container is received fresh unfixed labele:.  left sentinel lymph node #2 for frozen section". The specimen consists of an ovoid mass of tan-gray soft rubbery. tissue with attached fat. Frozen section is obtained by The entire specimen including frozen section in one block.
+
+--- Page 3 ---
+Page 3 Name Lab No.: C. The container is received fresh unfixed labele. sentinel lymph node #3 for frozen section". The specimen consist of an ovoid mass of pink-tan soft rubbery tissue measuring 1.3 cm. in diameter in the aggregate. Frozen section is obtained by. The entire specimen including frozen section in one block.. D. The container is received fresh unfixed labele. "left breast". The specimen consists of an 809 gm. apparent left breast which is 23 x 15 x 4 cm. in greatest overall dimension. There is an inverted nipple. The attached skin ellipse is 21 x 9.5 cm.. Sectioning through the breast stroma reveals dense gray-white fibrous tissue varying up to 7.5 cm. in greatest dimension. This area has been previously marked with blue dye. There are scattered cystic spaces varying up to 0.1 cm. in greatest dimension filled with. an amber-colored fluid. Sectioning also reveals a firm tan-gray striated tumor mass which is 7 x approximately 5.5 cm. in greatest overall dimension and is approximately 0.7 cm. from the deep/underlying resection margin. The specimen is submitted in ten blocks. Key Note Block Summary:1--nipple, 2 through 4---cystic spaces, 5-- random, 6 through 10---tumor mass. MICROSCOPIC EXAMINATION: MICROSCOPIC EXAMINATION CONDUCTED BY PATHOLOGIST CONFIRMS FINAL DIAGNOSIS SPECIAL STAINS PERFORMED:PanKeratin (specimens A,B,C)
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diff --git a/output/text/e96b2e30-ca31-4068-b932-1750af5500ec.txt b/output/text/e96b2e30-ca31-4068-b932-1750af5500ec.txt
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index 0000000000000000000000000000000000000000..cd25c6a8579bc9efeb9284e9e977748dde6147d5
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+Clinical Diagnosis & History: Biopsy proven left breast ILc, approximately 3-4 cm in left TM, SLn Biopsy, as well as right TM. Protocol -i-e. Presents for History of right. breast MRI guided core biopsy.. Specimens Submitted: 1: SP: Sentinel node #1 level one left. axilla (fs) 2: Sp: Sentinel node #2 level one left axilla (fs) 3: SP Sentinel node #3 level one left axilla. SP: Right breast. s 4: 5: SP: Left breast 6: Sp: Additional lyapn node, left axilla DIAGNOSIS: SENTINEL LYMPH NODE #1, LEVEL I LEFT AXILLA, EXCISION: Jcs-0-3 ONE BENIGN LYMPH NODE (O/1). - ADDITIONAL H/E STAINED SECTIONS AND IMMUNOPEROXIDASE STAINS FOR Caicione, hifiltnatng lobula 852of CYTOXERATINS (AET:AE3) SHON NO EVIDENCE OF METASTATIC CARCINOMA. Sit: bresot, Nos C50.9 2) SENTINEL LYMPH NODE #2. LEVEL I LEFT AXILLA, EXCISION: Hru/1 ONE BENIGN LYMPH NODE C/1). ADDITIONAL K/E STAINED SECTIONS AND IMMUNOPEROXIDASE STAINS FOR M CYTOKERATINS (AEI:AE3) SHOW NO EVIDENCE OF METASTATIC CARCINOMA. 3) SENTINEL LYMPH NODE #3. LEVEL I LEFT AXILLA. EXCISION: - METASTATIC CARCINOMA IN THE FORM OF MICROSCOPIC CLUSTERS AND SINGLE CELLS IS IDENTIFIED IN ONE OP ONE LYMPH NODE ON ADDITIONAL CYTOKERATINS IMMUNOHISTOCHEMICAL STAINS (AEI:AE3). EACH CLUSTER OF CARCINOMA MEASURES LESS THAN O.2 MM, BUT SEVERAL. CLUSTERS ARE PRESENT DISPERSED THROUGHOUT THE LYMPH NODE, ADDING UP TO ABOUT 300-400 CSLLS IN. TOTAL. RARE TUMOR CLUSTERS ARE ALSO IDENTIFIBD ON ADDITIONAL H/E STAINED SECTIONS. 4) BREAST, RIGHT TOTAL MASTECTOMY: - BENIGN BREAST TISSUE WITH FOCAL ATYPICAL DUCTAL HYPERPLASIA (ADH). COLUMNAR CELLS, FIBROADENOMATOID CHANGES AND BIOPSY SITE. - CALCIFICATIONS ARE ASSOCIATED WITH ADK AND BENIGN KPITHELIUM. BENIGN SKIN AND NIPPLE. 57 BREAST/ LEFT, TOTAL MASTECTOMY: ** Continued on next page GIM
+
+--- Page 2 ---
+DISTRIBUTED OVER AN AREA SPANNING ABOUT 6 CM GROSSLY. - BXTENSIVE LOBULAR CARCINOMA IN SITU (LCIS) IS ALSO IDENTIFIED. CLASSICAL TYPE (TYPE A). - THE INVASIVE CARCINOMA IS LOCATED IN THE UPPER OUTER QUADRANT AND LOWER OUTER QUADRANT. - NO INVOLVEMENT OF THE NIPPLE BY EITHER IN SITU OR INVASIVE CARCINOMA IS IDENTIFIED. - CALCIFICATIONS ARE PRESENT IN THE IN SITO AND INVASIVE CARCINOMA, ANDS IN BENIGN BREAST PARENCHYMA. NO VASCULAR INVASION IS NOTED. - NO PERINEURAL INVASION IS IDENTIPIED IN A SECTION IMMUNOSTAINED FOR CYTOKERATIN AE1:AE3. - INVASIVE CARCINOMA IS O.6 CM FROM THE NEAREST (DEEP) MARGIN. - NO SKIN INVOLVEMENT BY CARCINOMA IS IDENTIFIED. THE SKIN SHOWS SCAR. - THE NON-NEOPLASTIC BREAST TISSUE SHOWS BIOPSY SITE, FIBROADENOMATOID CHANGES AND APOCRINE METAPLASIA. IMMUNOHISTOCHEMICAL STAINS WERE PERFORMED ON FORMALIN-PIXED TISSUE WITHS THE FOLLOWING RESULTS FOR INVASIVE CARCINOMA (BLOCK 5-5) : ESTROGKN RECKPTOR (6R1I, VENTANA): 95 NUCLEAR STAINING WITH STRONG INTENSITY PROGESTERONE RECEPTOR (IE2; VENTANA) : 904 NUCLEAR STAINING WITH STRONG INTENSITY HER2 (HERCEPTEST; DAKO) : NEGATIVE (0) CONTROLS ARE SATISFACTORY. Comment: HercepTesttx (Dako) is an rDA-approved method for assessment of histological evaluation. The Her2 test rasults are reported in accordance. with the Asco/cAp guideline recommandations for HER2 t.sting in breast cancer (J Clin Oncol 2007; 25(1):118-145). Some of the immunohistochemistry and Ish tests were developed and their performance charactaristics were approved by the us Food and Drug Administration. The FDa has determined that such clearance or approval is not necessary. These tests axe used for clinical purposes. They should not be regarded as investigational or for research. This laboratory is cartified under the Clinical Laboratory Improvement Amendments of 1988 (cLIa : 88) as qualified to perform high Complexity clinieal laboratory tasting. 6) LYMPH NODE, LEFT AXILLA, EXCISION: - ONE BENIGN LYMPH NODE (O/1). I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Report Electronically Signed Out *** ** Continued on next page
+
+--- Page 3 ---
+1). The specimen is received fresh for frozen soction consultation, labeled "sentinel node #1, level 1, left axilla' and consists of a pink tan firm lymph node measuring 1.8 x 0.6 x 0.4 cm. The specimen is bisected and entirely submittad for frozen section. Summary of sections: Fsc .. frozen section control. 2). The specimen is received fresh for frozen section consultation, labeled "sentinel node #2, level 1. left axilla" and consists ot a pink tan firm. lyuph node measuring 2.8 x 1.5 x 0.4 cm. The specimen is bisected and ontirely submitted for frozen section. Sunmary of sections: Fsc -. frozen section control. 3). Tha speciman is raceived fresh for frozen section consultation, labeled "sentinel node #3, level 1. left axilla" and consists of two pink tan firm lymph nodes measuring 1.2 x 1.2 x 0.6 cm and 0.8 x 0.8 x 0.4 c. The specimen is bisected and entirely submitted for froren section. Sumnary of sections: Fsc -. frozen section control. 4). The specimen is received fresh labeled, -Right breast stitch marks axillary tail" and consists of a breast measuring 19 x 18 x 3.5 cm with skin surface is an averted nipple measuring 1.7 x 1.5 x 0.3 cm and areola measuring 3.7 x 3.4 cm. No visible scar is identified on ths skin surface. A suture demarcates the axillary aspect.  The posterior surface of the breast is inked black. the anterior surface in inked blue and the specimen is serially sectioned to raveal - dark red weil circumseribed biopsy cavity filled with red nemorrhagic material measuring 2.5 x 3 x 2 cm, and iocated in the midline of the lower quadrants and o.6"cm from the deep margin. clip is not identified in the specimen.. Sectioning of the axillary aspect. reveals no grossly identifiable lymph nodes. Representative sections are submitted. Sample of all quadrants were given to rps protocol. Summary of sections: N - nippl... NB - nipple base. S - skin scar. - deep margin. *. Continued on next page **
+
+--- Page 4 ---
+BX biopsy site UIQ - upper  inner quadrant LIQ - lower inner quadrant UOQ upper  outer quadrant LOQ outer quadrant 5). The specimen is received fresh labeled. *left breast" and consists of a breast measuring 23 x 19 x 2 cm with overlying skin ellipse measuring 9 x 4 cm. Situated center on the skin surface is a nipple measuring 1.5 x 1.2 cm. and areola measuring 3.2 x 3.2 cm. The skin shows a linear scar measuring cm, situated laterai to the nipple. A suture demarcates the axillary aspect. The posterior surface of the breast is inked black, the anteriox blue and th. axillary aspect is inkod yellow. The specimen is serially. sectioned to reveal a tan white firm stellate tumor mass measuring 6 x 3.5 x 2.0 cm, located in LoQ o.5 cn from the deep margin, extending to the. Overlying skin.. A clip is not identifiad. Sectioning of the axillary aspect reveals no grossly identifiable lyaph nodes. Representative sections are submitted. Sunmary of sections: N - nipple NB - nipple base skin scar . deop  margin BX - - biopsy site tumor UIQ upper inner quadrant. LIQ lower inner quadrant UOQ upper outer quadrant LOQ lower outer quadrant 6). The specimen is received in formalin, labeled "additional lymph nodes. left axilia- and consists of irregular yellow tan lobulated tissue measuring. 0.8 x 0.3 x 0.3 cm. The specimen is antirely submitted. Summary of sections: LN- lymph nodes Summary of Sections:. Part I: SP: Sentinel node lavel Slock Sect. Sit. PCs 1 Fsc 1 Part 2: SP: Sentinel node #2 level one left axilla (fs) ** Continued on next page **
+
+--- Page 5 ---
+Block Page 5of7 Sect. Site PCa 1 Fsc 1 Part 3: SP Sentinel node #3  level ono left axilla (fs) Block Sact. Site PCs 1 FSC 1 Paxt 4: SP: Right breast (. Block Sect. Site PCs 4 Bx H a n D 1 LIQ LOQ HHH2 y y s 1 urQ 2 toQ Part 5: SP: Left breastd Block Sect. Site PCs 2 Bx H 2 D 2 LIQ 2N 2 Hn a n 2 LOQ y N 1 5 Part 6: SP Additional lymph node, left axilla Block Sact. Sit. PCs 1 LN Procedures/Addanda: Addandm Status: Signed out. By: Data Reported Addendum Diagnosis ADDENDUM PART #S LEFT BREAST: *+ Continued on next page **
+
+--- Page 6 ---
+INVASIVE LOBULAR CARCINOMA IS PRESENT IN TEN OUT OF NINETEEN SLIDES, andS involves upper outer and lower outer quadrants. A microscopic focus of invasive lobular carcinoma is also presaent in a section from the lower inner quadrant (<lom). THE SIZE OF THE INVAsiVE TUMOR IS DIFFICULT TO ASSESS IN THIS CASE. AS INVASIVE CARCINOMA IS PRESENT AS NULTIPLE NODULES,S MANY OF WHICH MERCE INTO ONE ANOTHER. THE LARGEST CONTIGOOUS SPAN OF INVASIVE CARCINOMA MEASURES AT LEAST 2.O CM MICROSCOPICALLY IN SLIDE S-10. IN THIS SLIDE THE TUMOR IS PERIPHERALLY TRANSECTED ALONG A BROAD FRONT. Intraoperative Consultation: Note: 'The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation.. FROzen SEcrIon DIaGOsis: Sp: Sentinel node #1 level one left axilla (fs Benign PERMANENT DIAGNOSIS: SAME FROzkn SecTroN r-aGNosis: Sp: Sentinel noda #2 lavel one left axilla (fs) : Benign PERMANENT DIAGNOSIS: Same 3) FROZen SEcrron DiagnosIs: SP: Santinel node #3 level one left axilla s Benign PERMANENT DIAGNOSIS:S SEE FINAL Note: The diagnoses given in this section pertain only to th. tissue sample examined at the time of the intraoperative consultation.. 1) FRozen SrcTion DiaGNosrs: SP: Sentinel node #1 lavel one left axilla (fs)(  Benign TEKMANENT DIAGNOSIS: SAME 2) FROZEN SECTION DIAGNOSIS: SP Sentinel node #2 level one loft axilla (fs) Benign PERMANENT DIAGN. SAME 3) FROZEN SECTTA nrsancsis: Sp: Sentinel node #3 level one left axilla (fs : Benign ANENT DIAGNOSIS: SEE FINAL
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+
+--- Page 1 ---
+UUID:71F1B1F6-D19F-48F1-BADC-AE97F4DB5958 TCGA-ZN-A9VP-01A-PR Redacted Pathology Report Report Status:  Final Procedure Date: ID d-3 Mossthelisne,epithelied malienart 9Os2/3 Site : Pleurs Nss C38.4 yJ o/1314 PATHOLOGIC DIAGNOSIS: A. PORT SITE #1: Skin and subcutis with acute and chronic inflammation, granulation tissue and foreign body giant cell reaction to polarizable material, negative for tumor. B. RIB: Bone and bone marrow with maturing trilineage hematopoiesis, negative for tumor. C. LEVEL 2R NODE: One (l) lymph node, negative for tumor. D. SVC NODE: One (l) lymph node, negative for tumor. E. LEVEL 8 NODE: One (l) lymph node, negative for tumor. F. LEVEL 4R NODE: One (l) lymph node, negative for tumor. G. LEVEL 7 NODE: One (l) lymph node, negative for tumor. H. RIGHT LUNG, DIAPHRAGM AND PERICARDIUM, EXTRAPLEURAL PNEUMONECTOMYS (INCLUDING FSA) : DIFFUSE MALIGNANT MESOTHELIOMA, EPITHELIOID TYPE, SOLID ANDS TUBULOPAPILLARY PATTERNS. Tumor involves: chest wall parietal pleura, maximal thickness of 0.8 cm,.  mediastinal pleura, and diaphragmatic pleura. Tumor involves visceral pleura.. Visceral pleural involvement by tumor is confluent and includes an interlobar fissure. Tumor invades lung parenchyma in two foci. Tumor invades pericardium but does not extend to the inner surface of. the pericardium. Diaphragmatic, pleural and bronchial resection margins are free of. tumor. Tumor is <0.l cm from apical, lateral, medial, anterior, posterior parietal pleural resection margins. Lymphovascular invasion is not identified. Hyaline pleural plaque is not identified. Mild pulmonary emphysema is present.. "HILAR" LyMPH noDEs: Four (4) lymph nodes with no tumor present.. AJcc classification (7th edition): pT3 N2 (see below, part I).. I. Level 8 node #2. METASTATIC MEsOTHELIOMA, present as a microscopic focus within the subcapsular space of one (1) of three (3) lymph nodes. Page: 1 of 4
+
+--- Page 2 ---
+Pathology Report TISSUE SUBMITTED: A/1. Port site #1. B/2. Rib. c/3. Level 2R node. D/4. svc node. E/5. Level 8 node.. F/6. Level 4R node. G/7. Level 7 node. H/8. Right lung, diaphragm and pericardium (Fs). 1/9. Level 8 node #2.. O.R. CONSULTATION: SPECIMEN LABELED "#8 RIGHT LUNG DIAPHRAGM & PERICARDIUM" (FSA): Bronchial resection margin, negative for tumor.. The senior physician certifies that he/she personally conducted a gross and/or microscopic examination of the described specimen(s)~and rendered or confirmed the rapid diagnos(es) related thereto. GROSS DESCRIPTION: The specimen is received fresh, in eight parts, each labeled with the patient's name and medical record number. Part A, "#1. Port site #1", consists of a tan/yellow soft tissue fragment (3.9 x 3.9 x 1.4 cm) with attached skin ellipse (2.6 x 0.5 cm). The specimen consists of yellow lobulated adipose tissue with a central area of fibrosis. extending from the skin ellipse to the deepest aspect. There are no masses or. lesions identified. Representative sections are submitted for histologic. examination. Micro Al-A2: Soft tissue with skin ellipse in Al, 1 frag each, Rss.. Part B, "#2. Rib", consists of a portion of rib (15.2 x 2.1 cm) with attached red/brown fragments of skeletal muscle. There are no masses or lesions identified. A rib bone marrow squeeze is submitted for histologic examination. Micro Bl: Rib bone marrow squeeze, multi frags, Rss. Part C, "#2. Level 2R node", consists of a tan/pink lymph node (1.2 x 0.6 x 0.5 cm). The specimen is entirely submitted for histologic examination.. Micro Cl: Lymph node, 1 frag, Ess. Part D, "#4. svc node", consists of a tan/brown/yellow lymph node (1.8 x 0.7 x. 0.4 cm). The specimen is entirely submitted for histologic examination.. Micro Dl: Lymph node, 1 frag, Ess. Part E, "#5. Level 8 node", consists of a tan/brown anthracotic lymph node (1.0. x 0.9 x 0.4 cm). The specimen is entirely submitted for histologic. examination. Micro El: Lymph node, 1 frag, Ess. Part F, "#6. Level 4R node", consists of a tan/yellow soft tissue fragment (0.6 Page: 2 of 4
+
+--- Page 3 ---
+Pathology Report x 0.4 x 0.2 cm). The specimen is entirely submitted for histologic examination. Micro Fl: Soft tissue fragment, 1 frag, Ess. Part G, "#7. Level 7 node", consists of a tan/brown focally anthracotic lymph node (0.8 x 0.5 x 0.4 cm). The specimen is entirely submitted for histologic examination. Micro gl: Lymph node, 1 frag, Ess.. Part H, "#8. Right lung, diaphragm and pericardium (Fs)", consists of a 1518 gram moderately disrupted extrapleural pneumonectomy specimen (31 x 23 x 7.4 cm) including lung (21 x 14 x 5 cm), parietal pleura, pericardium (7 x 6 cm) and hemidiaphragm (18 x 11 x 1.2 cm). There is a bronchial resection margin (3.3 cm in length x 2.2 cm in diameter) that is submitted en face for frozen section analysis as FsA..  The parietal pleura is gray/white/brown, moderately. disrupted, and covered with multiple (greater than hundred) partially confluent Tumor is present close to all pleural resection margins. The visceral pleura contains multiple (greater than fifty) tan/white partially confluent nodules (up to 1 cm).  Tumor bulges (1.7 cm) into lung parenchyma of  all lobes and thickened up to (1.2 cm) the entire distance of all intralobar septae. The diaphragmatic parietal pleura is fused (lo0%) and thickened (l.4 cm) by nodular tumor. The diaphragmatic margins are grossly free of tumor with the closest approach to tumor being 0.5 cm from the anterior margin. The tumor invades to a depth of. 0.2 cm into the muscle of diaphragm, but the inferior surface is free of tumor. There are mild emphysematous changes in the peripheral lung parenchyma. There are three firm anthracotic hilar lymph nodes, the largest measuring 1.3 cm in greatest dimension. Micro Hl: Bronchial resection margin, en face, FsA remnant, 1 frag, Ess. Micro H2: Apical parietal pleural margin, 1 frag, Rss. Micro H3: Medial parietal pleural margin, 1 frag, Rss. Micro H4: Lateral parietal pleural margin, 1 frag, Rss. Micro H5: Anterior parietal pleural margin, Micro H6: Posterior parietal pleural margin, 1 frag, Rss. Micro H7: Medial diaphragm margin, 1 frag, Rss.. Micro H8: Lateral diaphragm margin, 1 frag, RSS. Micro H9: Anterior diaphragm margin, 1 frag, Rss.. Micro H10: Posterior diaphragm margin, 1 frag, Rss.. Micro Hll: Diaphragm, I frag, Rss. Micro H12: Tumor and intralobar septae, 1 frag, Rss. Micro H13-hi4: Tumor extension into lung parenchyma, 1 frag each, Rss. Micro H15: Uninvolved upper lobe, 1 1 frag, Rss. Micro H16: Uninvolved lower lobe, 1 frag, Rss. Micro H17: Pericardium with closest extension of tumor to pericardial surface, 1 frag, RSS. Micro Hl8: Hilar lymph nodes, 3 frags, Ess. Part I, "#9. Level 8 node #2", consists of tan/brown/yellow soft tissue fragment (3.0 x 1.1 x 0.6 cm). The specimen is entirely submitted for. histologic examination. Micro Il: Soft tissue fragment, 1 frag, Ess. By his/her signature below, the senior physician certifies that he/she personally conducted a microscopic examination ("gross only" exam if so stated) of the described specimen(s) and rendered or confirmed the diagnosis(es) related thereto. Page: 3 of 4
+
+--- Page 4 ---
+Pathology Report l 1f8fy Diagnos CM
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diff --git a/output/text/e9800013-c1f3-455e-90ab-e0cc23bdd7be.txt b/output/text/e9800013-c1f3-455e-90ab-e0cc23bdd7be.txt
new file mode 100644
index 0000000000000000000000000000000000000000..673b485c9028e00b547bc1effb4b54423c048774
--- /dev/null
+++ b/output/text/e9800013-c1f3-455e-90ab-e0cc23bdd7be.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Jcs-0-3 CarCiome,mnfiltratinq 1obulw, N0s 8520/3 Pih S;ts: Brst,tmrf c50.1 1J4|n h potio Diagnosis: 1. Invasive lobular breast carcinoma in the classical differentiation. variant (G ll) with extensive infiltration of the skin but no uiceration of the skin (tumor diameter 3 cm, minimum distance from dorsal resection margin 2.5 cm). Summary tumor classification: invasive lobular breast carcinoma, G II,. pT2pN0(0/10)L0V0R0, positive for estrogen and progesterone receptors, negative for C-erb B-2 oncoprotein. Follow-up finding: three times) A metastatic infiltration and also an influx of. individual cells of the invasive lobular beast carcinoma into the excised axillary lymph node is definitely excluded. The pN0 status is thus confirmed A-PR
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diff --git a/output/text/e9a00dab-0a01-438c-b33f-a2a2cf8a088c.txt b/output/text/e9a00dab-0a01-438c-b33f-a2a2cf8a088c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..38e3186ce9ad9f4e2622ac7de8852c4ae982c3fc
--- /dev/null
+++ b/output/text/e9a00dab-0a01-438c-b33f-a2a2cf8a088c.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+*** Diagnosis / Diagnoses: *** 1.: Small specimen with submesothelial fibrosis excised from the peritoneum. 2.: Resectate from a portion of the colon (sigmoid) with an ulcerated colon carcinoma, of. the histological type of a moderately differentiated colon carcinoma, that extends no. closer than 3 cm to the resection margin and occupies a circular portion of the intestinal wall over an length of 5 cm. Invasive spread of the tumor within all layers of the. intestinal wall as far as the neighboring mesocolic fatty tissue. Oral and aboral resection margin tumor-free. 27 mesocolic lymph nodes tumor-free, with uncharacteristic reactive changes. The tumor stage is thus pT3 pN0 (1/27), L0, V0, R0; G2
\ No newline at end of file
diff --git a/output/text/e9a727d0-fbfd-44bf-bbd8-570088a63a93.txt b/output/text/e9a727d0-fbfd-44bf-bbd8-570088a63a93.txt
new file mode 100644
index 0000000000000000000000000000000000000000..38d54d7ada098d927cefe444c72cb3c01ec37ad8
--- /dev/null
+++ b/output/text/e9a727d0-fbfd-44bf-bbd8-570088a63a93.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+FINAL DIAGNOSIS: Part 1: Left Axillary Sentinel Lymph node #1, biopsy - ONE LYMPH NODE, NEGATIVE FOR TUMOR (0/1). Part 2: breast, left, segmental mastectomy -- A.  INVASIVe DUCTaL CARCINOmA, NOTTIngHAm GRADE 3, (TUBULE fORmATiON - 3, nUCLEAR GRADE - 3, mItotic'rate -- 3, total scOre: 9/9). B.  INVASIVE CARCINOMA MEASURES 1.8 CM IN GREATEST DIMENSION (SLIDE 2B). C. DUCtAl CArCinOmA iN SItu (DCiS), nUCLEAR GrADE 3, SOLiD And mICrOpaPiLLAry types WItH COMEDO NECROSIS AND ASSOCIATED CALCIFICATIONS. D. DCIS IS PRESENT OUTSIDE OF INVASIVE CARCINOMA COMPONENT (See COmment). E.  MARGINS OF RESECTION ARE NEGATIVE FOR INVASIVE CARCINOMA, INVASIVE CARCINOMA IS 0.9 CM FrOm CLOSESt (ANTERIOR) MARGIN OF RESECTION. F. DCIS IS PRESENT AT INFERIOR MARGIN OF RESECTION. G.  NO LYMPHOVASCULAR INVASION IS IDENTIFIED (see Comment). H. ATYPICAl DUCTAl HYPERPLASIA. FIBROCYSTIC CHANGES WITH COLUMNAR CELL CHANgE AND DUCTAL EPITHELiAL HYPERPLASIA. J. INVASIVE CARCINOMA IS nEGATIVE fOR ESTROGEN AND PROGESTERONE RECEPTORS AND nEGATIVE FOr her-2/neu wIth A ScOre Of 0, As per previOus patholOgy repORt  1c-0-3 Canciona, mnfiDtraHwg ouchf, nos 85og]j Sit: brest Nos. C50.9 3//u COMMENT: The in situ carcinoma is noted outsite of invasive carcinoma component, near the inferior margin, focally involving the inferior margin, in three out of fifty-eight slides. Entire specimen was submitted for histological evaluation.. No definite lymphovascular invasion was seen in the current specimen. No lymphatic invasion was seon in the previous biopsy specimen confirmed by D2-40 stain. However, vascular space invasion was seen in the previous biopsy. confirmed by CD31 stain. This data will be used for filling the synoptic template. UUID:CB0C2E8E-2D5D-492C-9C7E-0ECD0458425A Redacted TCGA-BH-A0BG-01A-PR
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diff --git a/output/text/e9db252f-284b-406e-86dd-d987ab110b2b.txt b/output/text/e9db252f-284b-406e-86dd-d987ab110b2b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4cc5b27e9ead9b904a21acfc08e1d9e8a78cea43
--- /dev/null
+++ b/output/text/e9db252f-284b-406e-86dd-d987ab110b2b.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Findings and diagnosis relating to the problem: The material in I) - as regards block A - shows a marked finding in terms of an adenocarcinoma of the colon with characteristic tumor cell groups, mostly in a tubular arrangement, and a marked tendency to spread to the fatty connective tissue, as well as moderate to low-grade lymph nodes (G2 to 3, pT3, L1, V1) The material also shows seven conglomerate metastases of the carcinoma described with extensive necrosis (7 of 18) and - with regard to the resection margins - free resection margins. here of the cryptic epithelium type with goblet cells, regular submucosa and muscularis and in II a regular anastomosis ring, here with regular cryptic epithelium, lined with goblet cells, isolated lymph follicles and regular submucosa and muscularis. Tumor classification: ICDO-DA M-8140/3, G2 to 3, pT3, L1, V1, pN2, locally R0
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diff --git a/output/text/e9db776a-3fa6-414f-b4ee-2a0af137b4ed.txt b/output/text/e9db776a-3fa6-414f-b4ee-2a0af137b4ed.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3434309e3bf36e8ba175b31f79dcf9d5056ccf52
--- /dev/null
+++ b/output/text/e9db776a-3fa6-414f-b4ee-2a0af137b4ed.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Procurement Date aterality:Left, upper outer quadrant Path RepOrt:BREAST TISSUE CHECKLIST Specimen type: Lumpectomy 1cs-0- 3 Specimen size: Not specified caucioma, ifi/trntinq 1obnlw,N1s 8520/3 Site Susst, NOS c50.9 Tumor site: Breast hs 7/37/ Tumor size: 2.4 x 0 x 2.8 cm Grossly evident lesion: Yes Histologic type: Lobular carcinoma UUID:1DFFCBD1-962D-4E9B-BEE1-726CABE3AA95 Redacted TCGA-E9-A23S-01A-PR Histologic grade: Moderately differentiated. Tumor extent: Not specified Lymph nodes: 1/10 positive for metastasis (Axillary 1/10) Extracapsular invasion of the lymph nodes: Not specified Margins: Uninvolved. Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified. Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified. Additional pathologic findings: Not specified. Comments: None
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diff --git a/output/text/ea180946-7c2e-4178-89cc-1d782da72711.txt b/output/text/ea180946-7c2e-4178-89cc-1d782da72711.txt
new file mode 100644
index 0000000000000000000000000000000000000000..adf31664da279f0fae6bb6b2d96a28f18bca1136
--- /dev/null
+++ b/output/text/ea180946-7c2e-4178-89cc-1d782da72711.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Ics-0-3 Ca^cioms, n^f1+nsHNg duct,Nos 85oo/3 S,s: but, Nus C50-9 3/f iw page 1 / 2  Department of Cancer Pathology copy No. Date: Examination: Intraoperative examination Internal invoice No. Cost of diagnostic procedure Examination No.: Patient: XXX PeseL: XXX Age: Gender: F Material: 1. Partial organ resection -- Lesion in the right breast -- outer upper quad. Unit in charge:  Physician in charge: Material collected on Material received on Expected time of examination: 20 minutes (from receipt of material) Clinical diagnosis: Suspected breast cancer (PCI - cellulae atypicae, MMR and clinically- ca). Please review the tumour and margins.  Examination performed on: Result of intraoperative examination: Carcinoma invasivum Compliance validated by. Examination performed on: Macroscopic description: Fragment of the right breast sized 8 x 7 x 4 cm with a 5 x 2 cm skin flap, marked typically, no RTG. Tumour sized 2.5 x 1.5 x 1 cm in the cross section. Margins: 0.8 cm to the base; 1.3 cm to the front surface; 2.5 cm to the sternum; 3 cm to the axilla; 4 cm to the shoulder; 1.3 cm to the lower boundary.. Preliminary result: Carcinoma ductale invasivum NHG2 (3 + 2 + 2/9 mitoses/10 HPF - visual area 0.55 mm). Carcinoma ductale in situ, solid type with high nuclear atypia with comedo necrosis and calcifications. Final diagnosis after all material are analysed. Compliance validated by:. Examination performed on: UUID:E1907A10-2078-41F1-888B-24D5B5518D05 TCGA-D8-A13G-01A-PR Results of immunohistochemical examination: Redacted No estrogen receptors found in neoplastic cell nuclei. No progesterone receptors found in neoplastic cell nuclei. HER2 protein stained with HercepTestTM by DAKO. Score = 2+ , FIsH verification recommended. Compliance validated by: DISQUALHIED
+
+--- Page 2 ---
+Examination: Histopathological examinationpage 2 / 2 Examination No.: Patient: XXX PESEL: XXX Gender: F Examination performed on: Microscopic description Carcinoma ductale invasivum NGH2 (3 + 2 + 2/9 mitoses/ 10 HPF/ visual area diameter 0.55 mm). Carcinoma ductale in situ, solid type with high nuclear atypia with comedo necrosis and calcifications. Margins of normal tissues as in the macroscopic description. Reactivo lymphocytaria peritumoralis. Additionally, mastopathia fibrosa et cystica. Histopathological diagnosis:e Carcinoma ductale invasivum et in situ mammae dextrae G2, pT2. invasive ductal carcinoma of the right breast Compliance validated by: Examination performed on. Results of immunohistochemical examination: RESULT OF HER2/neu GENE AMPLIFiCATION with the FISH method by Path Vysion HER2 DNA Probe Kit FINAL RESULT: HER-2 gene AMPLIFICATION NOt FOUND. Anna Malicka Compliance validated by: Examination performed on:. Supplementary test:. Including the examination No. Carcinoma ductale invasivum et in situ mammae dextrae. (NHG2, pT2, pN0) Compliance validated by
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diff --git a/output/text/ea71ef6e-0114-4c9f-82d1-9dcfb71aabde.txt b/output/text/ea71ef6e-0114-4c9f-82d1-9dcfb71aabde.txt
new file mode 100644
index 0000000000000000000000000000000000000000..163cc28bfcac12faef033918cfbe4ffc6cb76b99
--- /dev/null
+++ b/output/text/ea71ef6e-0114-4c9f-82d1-9dcfb71aabde.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Ics-0-3 Cnrcinomn, ductnl, nos, nifiltnnting 185^oo/3 Patient 1.7/1 lQlF brst sos C50.9 Surgical Pathology: Final- Surg Path CLINICAL HISTORY: Large carcinoma in right breast.. GROSS EXAMINATION: A. "Right.breast and axilla tissue", in formalin. Received is a 30 x 18 x 4 cm. mastectomy specimen with a 14 x 7.5 x 1.0 cm attached axillary tail. There is  Sectioning the specimen reveals a 5 x 4.5 x 4 cm mass in the mid upper outer quadrant consisting of firm, white, hemorrhagic tissue. The mass Is'2 cm from the deep surgical margin and 1 cm from the skin. ellipse. The remaining breast tissue appears unremarkable. The deep surgical. margin is inked blue. The axillary tail was sectioned into the proximal,. middle, and distal portion and lymph node candidates were identified.. BLOCK SUMMARY: A1- section of nipple. A2- tumor in surgical margin. A3- tumor and skin margin. A4- tumor. A5- upper outer quadrant. A6- upper inner quadrant. A7- lower outer quadrant. A8- lower inner quadrant. A9- proximal region three lymph node candidates. A10- mid region two lymph node candidates. UUID:F38AF04C-35EE-450F-BFA8-E9DFE9F984FD A11- mid region two  lymph node candidates. TCGA-B6-A0I3-01A-PR A12- mid region two lymph node candidates. Redacted A13- distal region viable candidates.. A14- distal region four lymph node candidates. A15- distal region four lymph node candidates. A16- distal region five lymph node candidates. A17- distal region one lymph node candidate. Dr. DIAGNOSIS: "RIGHT BREAST AND AXILLA TISSUE", (MASTECTOMY, AXILLARY DISSECTION) : A. INVASIVE DUCTAL CARCINOMA, NSABP HISTOLOGIC GRADE III, CYTOLOGIC GRADE III. TUMOR MEASURES 5 CM IN ITS GREATEST DIMENSION. TUMOR EXTENDS TO WITHIN 2 CM OF THE DEEP SURGICAL MARGIN. 27 LYMPH NODES, ALL NEGATIVE FOR MALIGNANCY. BENIGN PROLIFERATIVE CHANGES INCLUDE BLUNT DUCT ADENOSIS, INTRADUCTAL HYPERPLASIA, AND FIBROSIS. OPERATIVE MARGINS FREE OF MALIGNANCY IN SECTIONS OBTAINED. COMMENT :  No identifiable intraductal carcinoma is seen. Verified by: Dat: eBrowser Result for I of 1
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diff --git a/output/text/ea92df9a-d919-4e20-9fc2-64e1f38ff12b.txt b/output/text/ea92df9a-d919-4e20-9fc2-64e1f38ff12b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..29274c7e165fade46b2581fe54f8f115d44b9b2e
--- /dev/null
+++ b/output/text/ea92df9a-d919-4e20-9fc2-64e1f38ff12b.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+Jcs.0-3 Carcinonn, hepatocilluler, Nos 8/7o/3 Sit: lwu co2.0 Patient Key: Surgical date: TISSUE DESCRIPTION: :1 A2 B1 C1 C2 C3 C4 C5 C6 C7 C8 C9 C1O C11 C12 C13 C14 C15 Right lobe liver (2890.0 grams, 24.3 x 22.0 x 13.3 cm), a pericholedochal lymph node (2.1 x 1.1 x 0.8 cm), and gallbladder (9.2 x 4.4 x 2.1 cm). DIAGHOSIS: Liver, right lobe, resection: Grade 3 (of 4) hepatocellular carcinoma forming a 22.0 x 15.3 x 12.8 cm mass in the right lobe of noncirrhotic liver. The surgical margins are free of tumor by a minimum of 1.1 cm. A large (10.3 x 7.4 x 5.5 cm) subcapsular hematoma is also present. Lymph node, pericholedochal, excision: A single pericholedochal lymph node is negative for tumor Gallbladder, cholecystectomy: Mild chronic cholecystitis with cholesterolosis and a single benign cystic duct lymph node are identified UUID:35CD5B20-BF61-4D28-AC7F-2CDC959382CD Redacted CGA-DD-A11C-01A-PR
+
+--- Page 2 ---
+Jcs-0-3 Cavcinoma hepatocellulw, Nos 8170/3 Sit:Lwer Coq.O. 1/24/1 h Patient Key: Surgical date: TISSUE DESCRIPTION: A1 A2 B1 C1 C2 C3 C4 C5 C6 C7 CB C9 C1O C11 C12 C13 C14 C15 Right lobe liver (2890.0 grams, 24.3 x 22.0 x 13.3 cm), a pericholedochal lymph node (2.1 x 1.1 x 0.8 cm), and gallbladder (9.2 x 4.4 x 2.1 cm). DIAGNOSIS : Liver, right lobe, resection: Grade 3 (of 4) hepatocellular carcinoma forming a 22.0 x 15.3 x 12.8 cm mass in the right lobe of noncirrhotic liver. The surgical margins are free of tumor by a. minimum of 1.1 cm.. A large (10.3 x 7.4 x 5.5 cm) subcapsular hematome is also present.. Lymph nade, pericholedochal, excision: A single pericholedochel lymph node is negative for tumor. Gallbladder, cholecystectomy: Mild chronic cholecystitis with cholesterolosis and a single benign cystic duct lymph node are identified
+
+--- Page 3 ---
+Liver - Digestive System CAP Approved * Data elements with asterisks are not required for accreditation purposes for thc Commission on Cancer. These elements may be clinieaily important. but are not yct validated or regularly used in putient munagement. Alternatively, the necessury data may not be available to the pathologist at the time ot pathologic assessinent of this specimen. LIVER: Resection Patient numc: (to be de-identified)Peient Key Surgical pathology number: Sjagery Dato : MACROSCOPIC Specimen Type iZ Right lobectomy Extended right lubectomy Medial segmchtectomy Left Iateral segmentcctomy Total left lobectony Explanted liver Other (specify): Not speciticd Fogality ^ solitary (specify location): Yuht lobe  Multiple (specity locution): Tumor Size 2210 Greatest dimension? Cannot be determined (see Comment) MICROSCOPIC Histologic Type V Hepatocellulur carcinoma Fibrolanellar hepatocellular carcinoma variant (spccify): Combined hepatocellular und cholangiocarcinoma Cholangiocarcinoma, intrahepalic Bile duct cystadenocarcinoma Undifferentiatcd carcinoma Othcr (specify): Carcinoma, typc cannot be determined Histologic Grade Not applicablc GX: Cannot be ussessed GI: Well differentiated SI1: Moderately difterentialcd  GllI: Poxtly differentiated GIV: Unditferentiatcd/anaplastic Other (specify):
+
+--- Page 4 ---
+Patient Kogi ps 2 Pathologic Staging (pTNM) Primary Tumor (pT) pTX: Cannot be assessed $TO: No evidence of prinary lumor V pT1: Solilary tumor with no vascular invasion pT2: Solitary tumor with vascular invasion or multiple tumors none morc than 5 cm pT3: Multiple tumors more than 5 cm or tumor invoiving a major branch of the pottal or hcpatic vein(s) pT4: Tumor(s) with direct invasion of adjacent orguns other than the gallbladder or pertoration of visceral peritoneum Regional Lymph Nodes (pN)  pNX: Cannot hc assessed L_ pN0: No regiona! lytmph node metastasis pN1: Rcgional lymph node metastasis Specity: Number examined: _2 Number involvcd:  Distant Metastasis (pM) V . pMX: Cannot be assessed  pM1: Distant metastasis *Spccify site(s), if known: Margins (check all that apply) Parenchymal Margin  Cunnot be assessed V Uninvolvcd by invasive carcinoma Specity margin: Involved by invasive carcinoma Bile Duct Margin (Cholangiocarcinomu Only) Cannot be asscssed Uninvolved by invasive carcinoma * Carcinoma in situ absent Carcinoma in situ present  Involved by invasive carcinoma Other Margin Specify margin: Cannot be assessed Uninvolved by invasive carcinoma Involved by invasive eurcinoma *Venous (Large Vesscl) Invasion (V) Absent Present *V Indcterminate *Agditionat Pathologic Findings (check all that apply) .. None identified Hepatoccllular dysplasia  Ductal dysplasia Cirrhosis/fibrosis Iron overloud Hepatitis (specity typc): Other (speeify): 6t'd
\ No newline at end of file
diff --git a/output/text/eab0c8af-3f4f-4fbd-b6a8-b3c06821ac11.txt b/output/text/eab0c8af-3f4f-4fbd-b6a8-b3c06821ac11.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0cbdb9d3d95d835b96c04421390147003a9c9354
--- /dev/null
+++ b/output/text/eab0c8af-3f4f-4fbd-b6a8-b3c06821ac11.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+S.t Ctu: brnst Nos c50.9 // Patien surgical fd  UUID:EFA0354A-641D-4EC2-A1BE-4ACC7CE421DF Surg Path Redacted CLINICAL HISTORY: Right breast Ca, rule out deep margin positive. GROSS EXAMINATION: A. "#1 right'modified radical mastectomy", in formalin. Received in the container is a portion of breast with an attached skin ellipse containing the nipple and an axillary dissection. The specimen measures 18.5 x 14 x 3.9 cm. The attached skin ellipse measures 14.7 x 6.3 cm. The nipple appears grossly unremarkable. There is a small 0.5 cm hole 1.7 cm inferior to the nipple. The deep surface of the specimen is inked in blue and the specimen is serially sectioned revealing a 3.5 x 2 x 1.5 cm firm white mass in the medial portion of the specimen..  The mass is fairly well-circumscribed but very firm to. palpation. Grossly it appears to approach within 0.2 cm of the deep surgical margin. There is no definite biopsy cavity; however, there is a small area of hemorrhage just adjacent to the tumor mass. Tissue from the tumor mass has been sent for estrogen and progesterone receptors. Block Summary: Al- section through nipple. A2- section through hole in skin ellipse.. A3-A5- sections of tumor with adjacent deep margin. A6-A9- representative sections of tumor. A10- representative sections of upper lateral quadrant. All- representative section of lower lateral quadrant.. A12- representative section of upper medial quadrant. A13- five lymph node candidates from level three. A14-Al5- one large lymph node bisected, level three. Al6- one large lymph node bisected and one small lymph node candidate, level three. A17- one lymph node candidate bisected, level three.. A18-- one lymph node candidate bisected, level three. A19- four lymph node candidates from level II. A20- one lymph node candidate bisected from level II. A21- two lymph node candidates from level II. A22- five lymph node candidates from level I. A23- two lymph node candidates from level I. A24- two lymph node candidates from level I.. A25- two lymph node candidates from level I. MICROSCOPIC EXAMINATION: Most of the tumor consists of tubules and cribriform glands composed of atypical cells with a moderate amount of eosinophilic cytoplasm and oval nuclei with distinct relatively small nucleoli. There is a sparse inflammatory response. A minor non-comedo intraductal component is present, within or near the tumor mass. Away from the tumor, no intraductal carcinoma or epithelial hyperplasia is seen. DIAGNOSIS: A. "RIGHT" BREAST,  MODIFIED RADICAL MASTECTOMY: INFILTRATING DUCTAL CARCINOMA (2.5 CM), NSABP HISTOLOGIC GRADE II/III, NUCLEAR GRADE MODERATELY DIFFERENTIATED. A NON-COMEDO INTRADUCTAL CARCINOMA COMPONENT IS IDENTIFIED, COMPRISING LESS THAN 10% OF THE CARCINOMA. NO TUMOR IS SEEN IN THE DEEP SURGICAL MARGIN. 1 of 2
+
+--- Page 2 ---
+NO VASCULAR INVASION IS IDENTIFIED. TWO OF SEVENTEEN (2/17) LYMPH NODES ARE POSITIVE FOR METASTATIC ADENOCARCINOMA. BREAST TISSUE WITH APOCRINE METAPLASIA AND MICROCALCIFICATIONS IN NON-NEOPLASTIC LOBULES. Verified by 2 of 2
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diff --git a/output/text/eac2519f-c87a-4653-92f5-36c67515bb42.txt b/output/text/eac2519f-c87a-4653-92f5-36c67515bb42.txt
new file mode 100644
index 0000000000000000000000000000000000000000..43aa974fb4260a4a9f4338a0d13b61b76bf48707
--- /dev/null
+++ b/output/text/eac2519f-c87a-4653-92f5-36c67515bb42.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:887F0E3A-DC70-4CD4-AAAF-3C613195D895 CGA-AR-A240-01A-PR Redacted Final Diagnosis bw 4f3sFn Breast, left, modified radical mastectomy: Multifocal lobular carcinoma with focal ductal features, Nottingham grade I (of III) forming two separate masses, 5.3 x 2.7 x 1.4 cm and 1.2 x 1.0 x 1.0 cm in the inferior and medial breast respectively (AJCC pT3) A biopsy cavity is identified adjacent to the tumor in the medial breast. Lymphovascular space invasion is not seen. The. remaining breast parenchyma shows adenosis and duct ectasia. The nipple shows no diagnostic abnormalities. Margins of. resection are negative for tumor (closest margin is anterior/inferior, free by at least 0.8 cm). Multiple (6 of 17) left axillary lymph nodes are involved by metastatic lobular carcinoma (AJCC pN2). Focal extracapsular extension is also present.. Her-2/NEU has been ordered on paraffin embedded tissue. /cs-0 -3 Carcmomn, mfilfrstntg ouct andL1obulw,Nrs 8522f3 Sit: brust, Nos c50.9 4/05
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diff --git a/output/text/ead3dff2-6ba1-4246-8c03-d7f57e97487a.txt b/output/text/ead3dff2-6ba1-4246-8c03-d7f57e97487a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f4abe5f721657a784f10f697d387212c484a5c3f
--- /dev/null
+++ b/output/text/ead3dff2-6ba1-4246-8c03-d7f57e97487a.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1. to 4.:Colon sigmoid) resection material shows tumor-free oral and aboral resection margins and includes an ulcerated,moderately differentiated adenocarcinoma with infiltration of the perimuscular fatty tissue,with two regional lymph node metastases and penetration of the peritoneum1.) and with serosa2.and liver metastases(3.and 4.G2 pT4 L1V0pN12/17pM1 HEP/PER)
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diff --git a/output/text/eaec4da1-d5e7-496e-abbd-268c142944b7.txt b/output/text/eaec4da1-d5e7-496e-abbd-268c142944b7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..62104d04ec44b4d0454c03a72d41995b0595c259
--- /dev/null
+++ b/output/text/eaec4da1-d5e7-496e-abbd-268c142944b7.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+Pathology Report Report Type ct Date of Event Sex Authored by Hosp/Group PATIENT HISTORY: Right maxillary cancer PRE-OP DIAGNOSIS: Right maxillary cancer.. POST-OP DIAGNOSIS: Same. URE : None given. FINAL DIAGNOSIS: PART 1: LYMPH NODES, RIGHT, LEVELS 2 THROUGH 4, EXCISION FORTY-THREE LYMPH NODES, NO TUMOR PRESENT (O/43). PARTS 2 4: LYMPH NODES, LEFT, LEVELS 2 THOROUGH 4, EXCISION THIRTY-NINE LYMPH NODES, NO TUMOR PRESENT (O/39). PARTS 5-9: RIGHT MAXILLA AND PALATE, RIGHT INFERIOR MAXILLARY MARGIN, MAXILLARY BONE FRAGMENT, ADDITIONAL MAXILLA RIGHT LATERAL AND SUPERIOR MARGIN AND ADDITIONAL LATERAL AND INFERIOR MARGIN, INFRASTRUCTURE PARTIALS MAXILLECTOMY, AND EXCISIONS A. POORLY DIFFERENTIATED SQUAMOUS CELL CARCINOMA (4.5 CM) WITH INVASION OF MAXILLARY BONE BONE AND SALIVARY GLAND TISSUE. B. PERINEURAL INVASION IS IDENTIFIED. C. NO ANGIOLYMPHATIC INVASION IS IDENTIFIED. D. ALL FINAL MARGINS OF RESECTION ARE FREE OF TUMOR. PATHOLOGIC STAGE pT4a, NO, MX. My s? station that I have personally reviewed the submitted material(s) and the final diagnosis reflects that evaluation. GROSS DESCRIPTION: The specimen is received in nine parts. Part 1 is received unfixed, labeled with the patient's name, initials, xx and "selective node dissection right, levels 2 through 4, stitch at 2B". The. specimen consists of a solitary 9.6 x 5.0 x 1.6 fibrofatty, focally. hemorrhagic tissue fragment with a black suture that marks level 2B. Lymph nodes are dissected and are submitted as follows: 1A 1B representative level 2 lymph node 1C level 2, two nodes 1D level 2, four nodes 1E level 2, four nodes 1F level 2, two nodes 1G level 2b four nodes 1H level 2b three nodes
+
+--- Page 2 ---
+11 level 3, four nodes 1J level four nodes 1K level 3, one node bisected 1L level 3, four nodes 1M level 4, four nodes 1N level 4, three nodes 10 level 4, three nodes. Part 2 is received in formalin labeled with the patient's name, initials xx and "lymph node level 4". The specimen consists of a 2.5 x 1.6 x 0.5 cm focally hemorrhagic fibrofatty tissue fragment. Lymph nodes are recovered and submitted as follows: 2A two nodes 2B one node. Part 3 is received in formalin labeled with the patient's name, initials xx and "lymph node zone 2". The specimen consists of a 2.0 x 1.0 x 0.5 cm fibrofatty tissue fragment. The specimen is submitted as follows: 3A  one node 3B two nodes. Part 4 is received in formalin labeled with the patient's name, initials xx and "lymph node 2-4". The specimen consists of an 8.3 x 3.0 x 1.2 cm fibrofatty tissue fragment with a suture that demarcates level 2b nodes. The specimen is submitted as follows: 4A level 2, node A 4B level 2, node B 4C level 3, node A 4D level  3, node B 4E level 3, node c 4F level 4, node A 4G level 4, node B 4H loose fragment of tissue (two nodes) 4I level 2, two nodes 4K two nodes 4J level 2, four nodes 4K level 2,  five nodes 4 L level 2, one node 4M level 2, two nodes 4N level 3, three nodes 40 level 3, four nodes 4P level 4, two nodes 4Q level 4, three nodes 4R level 4, three nodes. Part 5 is received in formalin labeled with the patient's name, initials xx and "maxillary mucosa". The specimen consists of a 3.0 x 4.0 x 1.0 cm fragment of mucosal lined soft tissue. A representative section is submitted in cassette 5A. Part 6 is received unfixed for intraoperative consultation labeled with the patient's name, initials, xx and "right inferior maxillary, suture right resection of the maxillary sinus. This specimen is 6.6 x 5.0 x 2.2 cm with a stitch that demarcates the right lateral margin. The sinus mucosa is grossly unremarkable. On the inferior aspect of the specimen there is a 4.5 x 3.0 x 1.0 cm focally hemorrhagic friable mass that breaks through the superior cribriform plate. The tumor breaks through the bone; however, the anterior, superior and nasal septal bony margins appear to be grossly free. The lesion is 1.5 cm from the anterior margin, 1.5 cm from the medial margin and 0.6 cm
+
+--- Page 3 ---
+from the posterior margin. However, it is close, if not approximates, the lateral margin. A digital photograph is taken of the inferior aspect of the specimen with the tumor.  Representative sections are submitted as follows: 6AFs tissue nearest right lateral margin 6B anterior shave 6C medial shave 6D posterior shave 6E anterior bone 6F nasal septal bony margin (decalcification) 6G superior bony margin (posterior) (decalcification) 6H 6I tumor with bone (decalcification) 6J posterior soft tissue with tumor. 6K tumor in bone (decalcification) representative sections of tumor.. is received in formalin labeled with the patient's name, initials xx and "maxillary bone fragment."  The specimen consists of an aggregate of fragments of bone that is 1.0 x 1.0 x 0.3 cm. The specimen is submitted for decalcification in cassette 7A. Part 8 is received in formalin labeled with the patient's name, initials xx and "additional margin maxilla, right lateral plus superior." The specimen consists of a 5.5 x 0.1 x 0.3 cm focally hemorrhagic mucosa-lined tissue fragment. The specimen is submitted in its entirety in 8A or 8B. and "additional margin lateral and inferior." The specimen consists of a 2.0 x 1.5 x 0.6 cm focally hemorrhagic, soft tissue fragment that is submitted in tirety in cassettes 9A through 9B. S F IVE CONSULTATION: 6AFS: RIGHT INFERIOR MAXILLARY (frozen section) A.  MALIGNANT . B. INVASIVE SQUAMOUS CELL CARCINOMA.S C. TUMOR LESS THAN ONE HIGH POWERED FIELD FROM OFT MARGIN, ALL OTHER MARGINS GROSSLY DISTANT. COPIC: SYNOPTIC DATA - PRIMARY UPPER AERODIGESTIVE TRACT AND MINOR SALIVARY GLAND TUMORS SPECIMEN TYPE: Resection: maxilla and hard palate, right TUMOR SITE: Other: hard palate and maxillary sinus TUMOR SIZE: Greatest dimension: 4.5 cm. Additional dimensions: 3.0 x 1.0 cm HISTOLOGIC TYPE: Squamous cell carcinoma, conventional HISTOLOGIC GRADE: G1 PATHOLOGIC STAGING (pTNM) : pT4a pN0 Number of regional lymph nodes examined: 82 Number of regional lymph nodes involved: 0 pMX MARGINS: Margins uninvolved by tumor VENOUS/LYMPHATIC (LARGE/SMALL VESSEL) INVASION (V/L) : Absent PERINEURAL INVASION: Present ADDITIONAL PATHOLOGIC FINDINGS: Inflammation (type): chronic
+
+--- Page 4 ---
+Microscopic examination substantiates the above diagnosis. PROCEDURAL NOTES: FS PERMANENT level II, node A. neg neg level II, node B. neg neg level III, node A neg neg level III, node B neg neg level III, node C. neg neg level IV, node A. neg neg IV, node B neg neg The following statement applies to all immunohistochemistry, Insitu Hybridization Assays (Ish & FIsh), Molecular Anatomic Pathology, and Immunofluorescent Testing: The d its performance characteristics determined by. the Department of Pathology, as required by the. C regulations. The testing has not been cleared or approved for the. cific use by the U.S. Food and Drug Administration, but the FDA has determined such approval is not necessary for clinical use. HISTO TISSUE SUMMARY/SLIDES REVIEWED: Part 1: dissection lev. Taken: Received: Stain/c H&E x 1 b H&E x 1 c H&E x 1 D H&E x 1 E H&E F 1 H&E 1 G H&E x 1 H H&E I H&E x 1 J H&E 1 K H&E x L H&E 1 M H&E 1 N H&E x 1 0 FRZ AFS Single x 1 H&E x 1 AFS Part 2: 1 4 Taken: Received: Stain/cn H&E x 1 A H&E x 1 B H&E x c 1 H&E x D H&E 1 E H&E x 1 F H&E x 1 G H&E x 1 H Part 3: 1 2 Taken: Received: Stain/c H&E x 1 A H&E x 1 B H&E x 1 c
+
+--- Page 5 ---
+H&E x 1 D H&E x 1 E Part 4: 2-3-4 Taken: Received Stain/c H&E x A H&E x 1 B H&E x c H&E 1 D H&E X E H&E 1 F + H&E x 1 G H&E x H H&E x 1 I H&E x 1 J H&E 1 K H&E x L H&E x M H&E x 1 N H&E 1 0 H&E 4 1 P H&E x 1 Q H&E x 1 R Part 5 : y mucosa Taken: Received: Stain/d H&E x 1 A Part 6: maxillary Taken: Received: Stain/c H&E x 1 A H&E x B H&E 1 c + H&E 1 D H&E x 1 E H&E F H&E 1 G H&E H H&E x 1 I H&E X 1 J H&E 1 K H&E x 1 L H&E x 1 M Part  7: fragment Taken: Received: Stain/cr H&E x 1 A Part 8: gin maxilla rig perior Taken: Received: Stain/c H&E x 1 H&E x 1 B Part 9: gin lateral & Taken: Received: Stain/cr H&E x 1 A H&E x 1 B
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diff --git a/output/text/eb32c706-4358-4399-9bfd-115631b804bc.txt b/output/text/eb32c706-4358-4399-9bfd-115631b804bc.txt
new file mode 100644
index 0000000000000000000000000000000000000000..15b6c8c035d77bd916ff1ef218a466b0382b865e
--- /dev/null
+++ b/output/text/eb32c706-4358-4399-9bfd-115631b804bc.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+Type: Surgical Pathology Specimen Type: Kidney, partial or total resection Procedure Date: Ordering Provider: PATHOLOGIC DIAGNOSIS: RIGHT KIDNEY,NEPHRECTOMY (573 gm): RENAL CELL CARCINOMA, chromophobe variant (6.6 cm), Fuhrman nuclear grade 2-3/4 (see NOTE). Tumor is confined to the kidney Resection margins are negative for tumor. Vascular and ureteral margins of resection are negative for tumor. No lymphovascular invasion is seen. Immunohistochemistry performed at emonstrates the following staining profile in tumor cells: Negative-TFE3 AJCC (6th Edition)T1b NX MX Special stains to assess adjacent renal parenchyma will be issued as an addendum.
+
+--- Page 2 ---
+NOTE:Cytogenetic findings confirm the above diagnosis.See cytogenetics report CLINICAL DATA: History vith multiple sclerosis.Workup for sciatica found large R renal mass. Operation: Hand-assisted laparoscopic nephrectomy Operative Findings: Large right renal mass. Clinical Diagnosis: Renal cell CA mass. TISSUE SUBMITTED: #1 Right kidney GROSS DESCRIPTION: The specimen is received fresh, labcled with the patient?s name, unit number, and "1.Right kidney", and consists of 573 gm right nephrectomy specimen (16 x 11 x 8 cm),including a kidncy (15 x 7.5 x 6.3 cm) with attached perirenal adipose up to 6.0 cm).A 2.2 cm renal artcry diameter 0.5 cm), a 1.3 cm renal vein (diameter 0.9 cm), and a 8.5 cm ureter (0.5 cm) are present at the hilum and are grossly unremarkable.Gerota's fascia has been previously partially inked black. The specimen contains a well-circumscribed, tan/yellow, hcmorrhagic mass (6.6 x 6.3 x 5.8 cm), which expands to but does not grossly invade the renal capsule at the lower pole, 2.5 cm from the hilar vessels.The perirenal fat over the tumor is freely mobile, without gross evidence of involvement. Representative tumor was taken for cytogenetics,and tumor bank, and representative normal kidney was sent for IF,and tumor bank.
+
+--- Page 3 ---
+There is no adrenal gland present, and the remaining renal tissue is grossly unremarkable without additional lesions or other abnormalities. The renal pelvis is likewise grossly unremarkable, lined by light tan, trabecular mucosa without abnormality Micro A1:Vascular ureteral margins, 3 frags. Micro A2:Mass and closestinked, adipose tissue margin, 1 frag Micro A3:Mass, 1 frag, Micro A4:Mass and adjaccnt, uninvolved kidney, 2 frags Micro A5:Mass and adjacent renal vein, 1 frag Micro A6:Uninvolved kidney, 1 frag By his/her signature below, the senior physician certifies that he/she personally conducted a microscopic examination ("gross only" exam if so stated) of the described specimen(s) and rendered or confirmed the diagnosis(es) related thereto. ADDENDUM RENAL PATHOLOGY EVALUATION OF NON-NEOPLASTIC KIDNEY PARENCHYMA
+
+--- Page 4 ---
+RIGHT KIDNEY,NEPHRECTOMY MILD ARTERIAL AND ARTERIOLAR SCLEROSIS WITH HYALINOSIS (SEE NOTE) Note: The changes seen in the kidney parenchyma are mild and probably age-rclated. MICROSCOPIC DESCRIPTION: The section examined by light microscopy consists of kidney cortex and medulla There are 269 glomeruli present in the sample, of which 1 (0.4%) is globally obsolescent (sclerosed).The preserved glomeruli show normal cellularity and reveal no significant pathological changes.On PAS and Jones methenamine silver stains, the glomerular basement membrancs appear of normal thickness; "spikes", craters, or double contours are not evident. Tubules and interstitium are well preserved, with no significant tubular atrophy or interstitial fibrosis, as evidenced on the trichrome stain (AFOG).Arteries show mild subintimal sclerosis, and arterioles show mild medial sclerosis with focal segmental hyaline degeneration.
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diff --git a/output/text/eb33e4a4-e3c7-4e5b-a065-45ab62e83ea2.txt b/output/text/eb33e4a4-e3c7-4e5b-a065-45ab62e83ea2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fdf13bbddb21bbb3feb04cc5465466b201e4a548
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+page 1 / 2 copy No. Date: Examination: Histopathological examination Cost of diagnostic procedure Examination No.: Internal invoice No. peseL: XXX Age: jender: F Patient: XXX 140-0-3 Material: Multiple organ resection -- right breast:  chvci omo, nfiYfstny cuct.Nos 85o0f3 Unit in charge: - Physician in charge: Sit. bust, Nos c5u.9 Material collected on:' 1aterial received on: Expected time of examination: up to 8 working days Clinical diagnosis: Examination performed on:. Macroscopic description:. Right breastsized 20 x 14 x 5 cm removed along with axillary tissues sized 10 x 5 x 3 cm and a skin flap of 18 x 10 cm. Tumour found in the upper outer quadrant, located 3 cm from the upper boundary, 1 cm from the base and 1.5 cm from the skin. Microscopic description: Carcinoma ductale invasivum NHG3 (3+3+3: 20 mitoses/10 HPF - visual area: 0.55mm) Invasio carcinomatosa vasorum massiva. Mamilla sine laesionibus. Glandular tissue showing mastopathia fibrosa. Axillary lymph nodes: Metastases carcinomatosae in lymphonodis (No V / vil). Infiltratio telae perinodalis. Emboliae carcinomatosae vasorum. Histopathological diagnosis: Carcinoma ductale invasivum mammae dextrae. Invasive ductal carcinoma of'the right breast Metastases carcinomatosae in lymphonodis axillae (No V / vill). Cancer metastases in axillary lymph nodes (No V/Vl) .(NHG3, pT2, pN2a). Invasio carcinomatosa vasorum massiva. Massive vascular invasion. Compliance validated by: Examination performed on: Results of immunohistochemical examination: Estrogen receptors found in over 75% of neoplastic cell nuclei. Progesterone receptors found in over 75% of neoplastic cell nuclei. HER2 protein stained with Ventana's Pathway HER-2/neu (485) rabbit antibody. Score=2+, FIsZ verification recommended. UUID:E8D4229D-5049-4991-BDE0-AFC2CBC1827E TCGA-D8-A1Y3-01A-PR Redacted #+3/+1
+
+--- Page 2 ---
+Examination: Histopathological examinanon. Examination No.: 1 Patient: XXX pESEL: XXX Gender: F Examination performed on: :. Result of immunohistochemical examination: RESULT OF HER2/neu GENE AMPLIFICATION with the FISH method by Path Vysion HER2 DNA Probe Kit FINAL RESULT: HER-2 GENE AmPLIFiCATION nOt fOUND Compliance validated by: Supplementary information:. Size of the tumour 3.5 x 2.5 x 2.0 cm. Compliance validated by: CONTACT YOUR DOCTOR WITH THIS REPORT!
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diff --git a/output/text/eb46c014-288e-49cf-84fa-90d5d3b3bfb9.txt b/output/text/eb46c014-288e-49cf-84fa-90d5d3b3bfb9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..420a4864e68690579fed47167266b70220527945
--- /dev/null
+++ b/output/text/eb46c014-288e-49cf-84fa-90d5d3b3bfb9.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:47C0AD9A-A83E-45BD-ACF3-09F97D680BEC TCGA-KM-A7QA-01C-PR Redacted Patient Results Page 1 of 3 Admit Date: Gender: Male Birth Date* Age: Attending: Admit Protocol: Location: Surgical Pathology [OrderID: Final Results  Surgical Pathology  Final CASE NUMBER: IcD-0 3 DIAGNOSIS: 1. Portion of adrenal, left, resection: Adrenal gland, no tumor Ceurcinoio, renal cel seen. Chromophobe tyyee 831713 2. Kidney, left, radical nephrectomy: Renal cell carcinoma, Site O YiduyN0S chromophobe type, Paner grade 2; vascular invasion present. Vascular and ureteral margins are free of tumor. See Note. C64.9 3. Lymph node, para and interaortic, resection: Nineteen lymph tO 9/Q41 i3 nodes, no tumor seen (0/19). NOTE: Please refer to the following for staging information. CAP cancer checklist: KIDNEY: Nephrectomy, Radical Procedure: Radical nephrectomy Specimen Laterality: Left Tumor Site: Upper pole Tumor Size (largest tumor if multiple): Greatest dimension: 8.0 cm, Additional dimensions: 7.0 x 4.0 cm Tumor Focality: Unifocal, Macroscopic Extent of Tumor. Tumor limited to kidney. No capsular or perinephric fat invaslon identifled. Histologic Type: Chromophobe renal cell carcinoma Sarcomatoid Features: Not identified Tumor Necrosis (any amount): Not identified Histologic Grade: Other (specify): Paner grade 2 Microscopic Tumor Extension: Tumor limited to kidney Margins: Margins uninvolved by invasive carcinoma Lymph-Vascular Invasion: Present Pathologic Staging (pTNM) Primary Tumor (pT): pT2a: Tumor more than 7 cm but less than or equal to 10 cm in greatest dimension, limited to the kidney Regional Lymph Nodes (pN) pN0: No regional lymph node metastasis Number of Lymph Nodes Examined, Specify: 19 Number of Lymph Nodes Involved, Specify: 0 Distant Metastasis (pM): Not applicable Pathologic Findings in Nonneoplastic Kidney: None identified Other Tumors and/or Tumor-like Lesions: None. Immunoperoxidase and in-situ hybridization tests performed here and used for diagnosis were developed and their performance characteristics determined by the '  They have not been cleared or approved by the U.S. Food and Drug Administration. The FDA has also determined that such clearance or approval is not necessary. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA) as qualified to perform high complexity clinical laboratory testing. Contidential Patient Information. Uuauthorized disclosure is prohibited by the Federal Privacy Act ot 1974. JobID. Requested By: Do not file in Medical Record
+
+--- Page 2 ---
+Patient Results  Page 2 of 3 Admit Protocol: Birth Date: Gender: Male Age: Admit Protocol: Admit Protocol: Location: Surgical Pathology (OrderID: Final Results CLINICAL INFORMATION: Brief Clinical History: left renal tumor Specimen Taken For Protocol: 01 - Yes Allocate Order to Protocol:.  PROCEDuRE: Operative Findings: left kidney and retroperitoneal lymph nodes removed  Post-Operative Diagnosis: left renal tumor Pre-Operative Diagnosis: left renal tumor SPECIMENS SUBMITTED: 1. ADRENAL GLAND, LEFT, Portio n of Gland 2. KIDNEY, LEFT, Portion of gland 3. LYMPH NODES, Para and Inter Aortic Caval GROSS DESCRIPTION:  Received at Surgical Pathology is a formalin-filled container labeled with the patient's name, medical record number, date of birth, and further designated as: 1. "Portion left adrenal gland". The specimen consists of an adrenal gland segment measuring 4 x 1 x 1 cm. There is no palpable nodule within the specimen. The specimen is serially sectioned and submitted entirely in 5 white cassettes labeled as iA-1E. 2. "Left kidney". The specimen consists of an intact kidney with  attached perinephric fat measuring 16 x 9 x 6 cm and weighing 343 grams collectively. The isolated kidney measures 14.8 x 8.4 x 5.5 cm and weighs 305 grams. The perirenal fat capsule is inked with black. Extending from the renal pelvis are 2 ureters.  The upper  ureter is 5 cm in length and 0.4 cm in diameter. The lower ureter is 8 cm in length and 0.5 cm in diameter. Renal vein is 0.5 cm in  length and 0.6 cm in diameter and the upper renal artery branch is 1.8 cm in length and 0.5 cm in diameter, the lower one is 1.0 cm In length and 0.4 cm in diameter. The perirenal fat layer is stripped, revealing the intact renal capsule, which is inked blue. Tumor does not extend to the ureters, arteries, and vein and is not present at the resection margin. The kidney is bisected, revealing an 8 x 7 x 4 cm circumscribed solid pink mass without hemorrhage and necrosis in the upper pole of the left kidney. It is 1.0 cm from the renal hilum. The mass is confined by the renal capsule and does not invade the perinephric fat. The uninvolved renal parenchyma is tan-brown with a well-defined cortical medullary junction and ordery cortical striations and medullary raise. The pelvis and calyx appear smooth. There are no lymph nodes or stones identified. Gross photographs are taken. In the upper pole, there is a 0.5-cm erythematic area, presumably the core biopsy site. Representative sections are submitted as follows: A-D - relationship between tumor and the renal capsule. E-G - relationship between tumor and the pelvis. H - relationship between tumor and normal kidney tissue I-O, X-Z, AA, BB - representative sections of the tumor. R - the upper ureter margin Contidential Patient Intormation. Unauthorized disclosure is prohibited by the Federal Privacy Act ot 1 974. JobID: Requested By: Do not file in Medical Record
+
+--- Page 3 ---
+Patient Results Page 3 of 3 Admit Protocol: Gender: Male Birth Date: Age: Admit Protocol: Admit Protocol: Location: ' Surgical Pathology [OrderID: Final Results S - lower ureter margin. T -- resection margin from the two renal artery branches.n. U - resection margin of the vein. V - kidney parenchyma where the core biopsy is done. W - the perirenal fat. 3. "Para and interaortic lymph node". The specimen consists of a fibroadipose tissue fragment measuring 4 x 3 x 3 cm. 16 candidate Iymph nodes are appreciated ranging from 0.4 to 1.0 cm in greatest  dimension. They are submitted entirely in 5 white cassettes labeled as Gross Description dictated by No consultants Accessioned: Final Report Signed Out:  <Resident Signature> PhD, CLINICAL RESIDENT <Sign Out Dr. Signature> MD, ATTENDING STAFF PATHOLOGIST Date Report Signed: Contidential Patient Intormation. Unauthorized disclosure is prohibited by the Federal Privacy Act ot 1974. JobID: Requested By: Do not file in Medical Record.
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diff --git a/output/text/eb62a943-d9e7-4d3c-8092-d4306cd35093.txt b/output/text/eb62a943-d9e7-4d3c-8092-d4306cd35093.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3d78aff056b65dd3b9fe4abd1cf62a8f8bb9fa16
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+Sample ID # Diagnosis: Right hemicolectomy preparation with tumor-free resection margins and an ulcerated, moderately differentiated adenocarcinoma of the ascending colon, with infiltration of the perimuscular fatty tissue and without Iocal lymph node metastases (G2, pT3 L0 V0 R0 pN0 0/34). 1cs-0-3 8140/3 hdenocarcinoma, NO5 Sih: ascmdig Cu(oN C18.2 3/29/ UUID: 8159A57E-D8E0-406E-9DAC-3E26E8E818A9 TCGA-AA-A00A-01A-PR Redacted
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diff --git a/output/text/eb7dc71f-363d-4437-ab9e-b50512cd8de3.txt b/output/text/eb7dc71f-363d-4437-ab9e-b50512cd8de3.txt
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index 0000000000000000000000000000000000000000..312190399cd27c802ac092852a44248d4918b569
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+FINAL DIAGNOSIS: Part 1: RIght Sentinel Lymph nODe #1, biOpSy - OnE LyMPh nODE NEGATIVE fOR TUMOR (0/1). 1cD-0-3 Part 2: right breast, segmental mastectomy -- 9i:bresf,No3 C5O.9 3/13/r pu inFILtRaTing DUct CArcinomA, 1.5 X 1.4 X 1.4 Cm. B. NOTTinghAm ScOre 9/9 (tUBULes 3, nucleaR 3, mitOses 3). C.  NO LYMPHOVASCULAR INVASION IDENTIFIED. D. DUCTAL. CARCiNOmA iN-SiTU SOLiD TYPE, NUCLEAR GRADE3, WITH COmEDO-TYpE NECROSIS COMPRISING APPROXIMATELY 3% OF iNVASIVE TUMOR AND PRESENT IN THE SURROUNDING BREAST TISSUE. E. SURGICAL MARGINS NEGATIVE FOR INFILTRATING DUCT CARCINOMA AND DUCTAL CARCINOMA IN- SITU. F. iNFILTRATING DUCT CARCINOMA FOCALLY VERY CLOSELY APPROACHES SUPERIOR MARGIN (0.03 CM). G. UNREMARKABLE SKIN. H. TUmOR IS ESTROgEN RECEPTORS, PROGESTERONE RECEPTORS AND hER2/NEU nEGATIVE AS PER COrE BIOPSy rEpORT 1. Thermal Effect. COMMENT: The tumor has pushing margins, is associated with prominent lymphocytic infiltrate and is cytokeratin 5 and 6,. cytokeratin 14, cytokeratin 17, epidermal growth factor and vimentin positive and estrogen and progesterone receptor CASE SYNOPSIS: SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST LATERALITy: Right PROCEDUrE: LOCaTIOn: Segmental Not specified Size OF TumOR: Maximum dimension invasive component: 1.4 cm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: TUMOR TYPE (invasive component): No Other Type(s): basal-like type NOTTINGHAM SCORE: Nuclear grade: 3 Tubule formation: 3 UUID:E800527B-1E37-420E-85E4-100630848C1C0 Mitotic activity score: 3 TCGA-BH-A0B9-01A-PR Redacted Total Nottingham score: 9 Nottingham grade (1, 2, 3): 3 ANGIOLYMPHATIC INVASION: No DERMAL LYMPHATIC INVASION: CALCIFICATION: No TumOr TYpE, iN SITU: No Solid, Comedo SURGICAL MARGINS iNVOLVED BY INVASIVE COMPONENT: No Distance of invasive tumor to closest margin: 0.3 mm SURG MARGINS INVOLVED BY IN SITU COMPONENT: LyMPH NODES POSITIVE: No 0 LYMPH NODES EXAMINED: METHOD(S) OF LymPh nODE EXAmINATIOn: H/E stain, Keratin stain SENTINEL NODE METASTASIS: SIZE OF NODAL METASTASES: No Diameter of largest lymph node metastasis: 0 mm LYMPH NODE METASTASIS(-ES) WITH EXTRACAPSULAR EXTENSION: No NON-NEOPLASTIC BREAST TISSUE: FCD t stage, pathologic: N Stage, pathologIc: pT1c M Stage, pathologic: pN0 pMX ESTROGeN RECEPTORS: PROGESTERONE RECEPTORS: negative HER2/NEU: negative zero or 1+ o/3/n
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diff --git a/output/text/eb8649d8-fc17-4b7e-8c7d-5ea1801da9f4.txt b/output/text/eb8649d8-fc17-4b7e-8c7d-5ea1801da9f4.txt
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index 0000000000000000000000000000000000000000..ce60eff68dc69d1c74a32cdc775502e8c514f545
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+IcD-0-3 850o|3 Canunoma, nifltratng dut, N0s c50.9 Sit Codi: breost, Nos 13/21fo lw Final Diagnosis Breast, left,wide local excision: Infiltrating ductal carcinoma, Nottingham grade II (of III) [tubules 2/3, nuclei 2/3, mitoses 3/3; Nottingham score 7/9], forming multiple (2) masses (0.7 x 0.3 x 0.3 cm and 4.3 x 3.4 x 3.2 cm [AJCC pT2]. Angiolymphatic invasion is present. The non- neoplastic breast parenchyma shows nonproliferative fibrocystic changes. All surgical resection margins, after separately submitted re-excisions of new deep/inferior, new anterior/inferior medial aspect, new medial/anterior, new medial/deep, new lateral, and new posterior/medial. margins, are negative for tumor (minimum tumor free margin, 1.0 cm, new medial/anterior and new medial/deep margins). Lymph nodes, left high axillary, dissection: Multiple (5) left high axillary lymph nodes are negative for tumor. Lymph nodes, left mid/low axillary, dissection: A single (of 12) left mid/low axillary lymph. node is positive for metastatic adenocarcinoma. The positive lymph node measures 1.0 x 0.9 x 0.7 cm. Faxitron done. UUID:180AA688-0B63-4DD9-BA29-708E80FBC4C9 TCGA-AR-A1AS-01A-PR Redacted 22
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diff --git a/output/text/eb9abc28-d650-46fb-b556-dc83474b67a9.txt b/output/text/eb9abc28-d650-46fb-b556-dc83474b67a9.txt
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index 0000000000000000000000000000000000000000..d557622b12c689049664b2897cd572d3d4ffaeac
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+SPECIMENS: A. RIGHT HEMICOLECTOMY DIAGNOSIS: A. RIGHT HEMICOLECTOMY WITH PARTIAL SEGMENTS 5-6: - MODERATELY TO POORLY DIFFERENTIATED ADENOCARCINOMA OF CECUM, TUMOR SIZE 6 X 3 CM. - CARCINOMA INFILTRATING THROUGH BOWEL WALL AND INVADING TO ADJACENT LIVER PARENCHYMA.  SURGICAL RESECTION MARGINS OF BOWEL AND LIVER TISSUE, FREE OF TUMOR - METASTATIC CARCINOMA PRESENT IN ONE OF THIRTY-SEVEN PERICOLIC LYMPH NODES (1/37).  SEE TEMPLATE. COLORECTAL CANCER TEMPLATE Specimen Type: Right hemicolectomy Tumor Site: Cecum Tumor Configuration: Exophytic, ulcerating Tumor Size: 6 x 3 x 3 cm Histologic Type: Adenocarcinoma Histologic Grade: G2-3, moderately to poorly differentiated Extent of Invasion: Adjacent structure: liver Margins: Uninvolved by invasive carcinoma (proximal, distal, radial) Venous/Lymphatic Invasion:. Indeterminate Perineural Invasion:  Present Additional Pathologic Findings:. NA Extent of Resection: R0: complete resection with grossly and microscopically negative margins. Lymph Nodes: Positive (1/37) Implants: NA EGFR Expression: pending Pathologic Stage: pT4a, N1 Mx SPECIMEN(S): A. RIGHT HEMICOLECTOMY CLINICAL HISTORY: Colon cancer GROSS DESCRIPTION:  RIGHT HEMICOLECTOMY WITH PARTIAL SEGMENTS 5-6 Received fresh is a segment of cecum with attached terminal ileum, overall measuring 15x14x6.5cm. Both ends are stapled. The attached terminal ileum is measuring 8cm in length, 3cm in diameter.. Attached to the cecum also identified a small piece of liver segment measuring 3.0x6.0x2.0cm. The serosa is inked black. Opening of the cecum reveals close to the ileocecal valve, there is a tumor which measures 6.0x3.0x3.0cm on the mucosa and 4.5cm away from the stapled distal margin on the colon and less than 1cm away from the ileocecal valve. The surface of the tumor is ulcerated and sectioning through the tumor reveals the tumor is already penetrating through the muscularis propria reaching into  the serosa, which might caused the adhesion to the liver. The rest of the mucosa in colon and terminal ileum are unremarkable. The sections are submitted as follows: A1: shaved margins from distal margin on the colon. A2: shaved margins from terminal ileum A3-A4: representative sections across the tumor into the adhered liver. A5: representative sections across the tumor into the ileocecal valve. A6-A8: representative section from the deepest invaded tumor A9: representative sections from grossly unremarkable mucosa in terminal ileum and colon A10: representative sections from appendix including the base, mid portion and tip. A11: additional section from the junction of tumor and liver.. A12-A16: 24 presumptive lymph nodes
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diff --git a/output/text/ebb456cd-ca21-498c-bbcb-a06a562b1116.txt b/output/text/ebb456cd-ca21-498c-bbcb-a06a562b1116.txt
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index 0000000000000000000000000000000000000000..7c8cac40d7a7aa45664c1797f02f57ed04b777da
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+UUID:8F2F2141- EC62-4321-B799-054D32FEBA87 anL ductol sn-iiti. TCGA-OK-A5Q2-01A-PR 8522 CgcF Coveurtmre Sobules uyystatiioy 854813 Sit' Infiltrating Lobular Carcinoma c58.4 CATEGORY: : BREAST INVASIVE CARCINOMA---INFILTRATING LOBULAR Qp4/z/13 CARCINOMA FROM PRIMARY BREAST SURGERY CLINICAL HX - Invasive lobular carcinoma. RIGHT BREAST, MASTECTOMY - Invasive lobular carcinoma, focally pleomorphic type, 3.0cm in greatest microscopic dimension, associated with extensive duct carcinoma in-situ (DCIS), intermediate nuclear grade, solid type with comedo necrosis. [Nottingham histologic grading system utilized- SBR score 7; architectural grade 3, nuclear grade 2, mitotic grade 2]. No lymphatic invasion is identified. Deep margin negative for tumor. Vessel wall calcifications. Intraductal papilloma, radial scar and fibrocystic changes including sclerosing adenosis. Skin and nipple, unremarkable. Prior biopsy site changes. RIGHT AXILLARY CONTENTS, EXCISION - Metastatic carcinoma present in two of the thirteen lymph nodes (2/13). Largest metastatic focus measures 4mm in greatest microscopic dimension. No extranodal extension is identified. Comment: AJCC pathologic stage pT2N1aMx. Synoptic summary will follow as an addendum. ADDENDUM 1: RIGHT BREAST, MASTECTOMY - Immunohistochemical stain for HER-2-NEU oncoprotein is negative (performed on formalin-fixed paraffin embedded sections by manual semiquantitative morphometric analysis with appropriate positive and negative controls). No membranous staining is seen. The HER-2-NEU procedure was performed using monoclonal antibody 4B5 and DAB detection system. (Staining interpretation: Weak = 1+; Moderate = 2+; Strong = 3+.) NOTE. This evaluation was performed according to ASCO/CAP guidelines: Positive HER2/neu cases are those with strong and complete membrane staining (3+) in greater than 30% of invasive cancer cells. Negative cases are defined as those with no staining (0) or weak, incomplete membrane staining (1+) in any proportion of cells. Equivocal cases are those cases with strong staining in less than or equal to 30% of cells, or less than strong but complete membrane staining (2+) in at least 10% of cells. Immunohistochemical stains were performed on formalin-fixed paraffin embedded tissue with appropriate positive and negative controls. ADDENDUM 2. Specimen Type - Mastectomy. Lymph node Sampling - Axillary dissection. Specimen Size - Greatest dimension 3cm. Histologic Type - Invasive lobular. Grading System - Nottingham. Tubule Formation - Minimal less than 10% (score = 3). Nuclear Pleomorphism - Moderate increase in size, etc (score = 2). Mitotic Count - 40X objective field with a field area of 0.152 mm2: 6 to 10 mitoses per 10 HPF (score = 2). Total Nottingham Score - Grade II: 6-7 points. Margins uninvolved by invasive carcinoma. Distance from closest margin: 5mm. Deep Primary Tumor [pT]: pT2 - Tumor greater than or equal to 2.0-5.0cm. Regional Nodes [pN]: pN1a: Metastasis in 1 to 3 axillary lymph nodes (at least 1 tumor deposit greater than 2.0mm). Number involved: 2. Number examined: 13. Distant Metastasis [pM]: pMX - cannot be assessed. FROM DIAGNOSIS CLINICAL HX - Right irregular mass, Right ax tail lymph node. RIGHT BREAST, 10:00 MASS, CORE BIOPSY - Invasive, lobular carcinoma with focal duct carcinoma in situ, solid type, low nuclear grade. Intraductal papilloma involved by lobular carcinoma in-situ. RIGHT AXILLA, LYMPH NODE, CORE BIOPSY - Lymph node with metastatic carcinoma histologically identical to breast carcinoma. COMMENT. Prognostic/predictive markers are being performed and results will follow as an addendum. ADDENDUM: Results of immunoperoxidase steroid receptor protein determination on paraffin sections, visually evaluated using DAB detection system and monoclonal antibodies (manual semiquantitative morphometric
+
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+analysis): ESTROGEN RECEPTOR PROTEIN (ER- clone SP1): POSITIVE; PROGESTERONE RECEPTOR PROTEIN (PR- clone 1E2): POSITIVE. Estimated percentage of nuclei staining positive (ER): 100; Estimated percentage of nuclei staining positive (PR): 25. Intensity of staining, ER: 3+ (strong). Intensity of staining, PR: 3+ (strong). Immunohistochemical stain for HER-2-NEU oncoprotein is NEGATIVE (performed on formalin-fixed paraffin embedded sections by manual semiquanitative morphometric analysis). No membranous staining is seen.. The HER-2-NEU procedure was performed using monoclonal antibody 4B5 and DAB detection system. 8
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diff --git a/output/text/ebbf5a13-006e-4758-b147-bf00165a1392.txt b/output/text/ebbf5a13-006e-4758-b147-bf00165a1392.txt
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index 0000000000000000000000000000000000000000..3fcab5379d6851ca6ff927f2ac09723fb50ccedb
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+1cs-0-3 sih, breut N0S c5U.y 1/25f lw FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974S SURGICAL PATHOLOGY REPORT Patient: FMP/SSN: DOB/Age/Sex: Specimen #: Location: Race: WHITE Physician(s) : Taken: Received: Reported: SPECIMEN: A: RIGHT BREAST B: LEFT BREAST C: SENTINEL LYMPH NODE #1 D: LEFT AXILLARY CONTENTS E: NON SENTINAL ,LT AXILLARY L.N. FINAL DIAGNOSIS: A. BREAST, RIGHT, MASTECTOMY: BENIGN BREAST TISSUE WITH FIBROCYSTIC CHANGES INCLUDING SCLEROSIS, MICROCYST FORMATION, USUAL DUCTAL HYPERPLASIA, DUCT ECTASIA, AND FOCAL MICROCALCIFICATION. B. BREAST, LEFT, MASTECTOMY: UUID:C8780DE7-E98C-4F7E-9487-8F25FE80DC210 TUMOR TYPE: INVASIVE DUCTAL CARCINOMA. TCGA-A2-A0CY-01A-PR Redacted NOTTINGHAM GRADE: III/III NOTTINGHAM SCORE: 9/9 (Tubules- 3, Nuclei= 3, Mitoses= 3) TUMOR SIZE (GREATEST DIMENSION OF INVASIVE COMPONENT): 3.5 CM) (MEASURED GROSSLY). TUMOR NECROSIS: PRESENT. VENOUS / LYMPHATIC INVASION: IDENTIFIED. MARGINS: DISTANCE OF TUMOR FROM NEAREST MARGIN IS O.4 CM, FROM THE SUPERFICIAL LOWER OUTER QUADRANT (BLUE INK) MARGIN. INTRADUCTAL COMPONENT: MULTIFOCAL, HIGH GRADE, SOLID AND COMEDO TYPE EXTENDING WELL BEYOND THE INVASIVE COMPONENT. LYMPH NODES: 1 OF 22 POSITIVE FOR TUMOR (PARTS C-E). NIPPLE INVOLVEMENT: NOT IDENTIFIED. SKIN INVOLVEMENT: NOT IDENTIFIED. ESTROGEN RECEPTORS: POSITIVE (STRONG, >75% OF CELLS, FROM PROGESTERONE RECEPTORS: NEGATIVE (WEAK, <5% OF CELLS, FROM HER 2 NEU by IHC: NEGATIVE (1+ STAINING, FROM PATHOLOGIC STAGE: pT2 N1 MX. ADDITIONAL PATHOLOGIC CHANGES: FIBROCYSTIC CHANGES INCLUDING MICROCYST FORMATION, DUCT ECTASIA, SCLEROIS, USUAL DUCTAL HYPERPLASIA, AND FOCAL APOCRINE METAPLASIA. C. LYMPH NODE, LEFT SENTINEL, EXCISION: - ONE (1) LYMPH NODE NEGATIVE FOR METASTATIC CARCINOMA BY HEMATOXYLIN AND EOSIN AND IMMUNOHISTOCHEMICAL (CYTOKERATIN) STAINS. Page 1 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 Continued on Next Page
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+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974S SURGICAL PATHOLOGY REPORT Patient: FINAL DIAGNOSIS (continued): Specimen #: D. LYMPH NODE, LEFT AXILLA, EXCISION: - TWENTY (2O) LYMPH NODES NEGATIVE FOR METASTATIC CARCINOMA. E. LYMPH NODE, LEFT NON-SENTINEL, EXCISION: - ONE (1) LYMPH NODE POSITIVE FOR METASTATIC CARCINOMA. COMMENT : In specimen "e" the frozen section diagnosis of metastic carcinoma is. confirmed on the permanent sections. ** Report Electronically Sianed Out ** CLINICAL DIAGNOSIS AND HISTORY: year old white female with history of left breast cancer. FROZEN SECTION DIAGNOSIS: SPECIMEN TYPE:LYMPH NODE (SPECIMEN "E"). TIME RECEIVED: TIME REPORTED: REPORTED TO: REPORTED BY # BLOCKS: AND 1 # SCRAPE PREPS:1 FROZEN SECTION DIAGNOSIS:POSITIVE FOR METASTATIC CARCINOMA. GROSS DESCRIPTION: A. Received in fresh labeled with the patient's name. labeled "RIGHT BREAST SHORT STITCH SUPERIOR, LONG STITCH LATERAL" COnSiStS of a 927 gram mastectomy specimen oriented with a short stitch superior and long iateral. The specimen measures 24 cm medial to lateral, 19 cm superior to inferior, and 5 cm anterior to posterior. The lightly pigmented superficial skin ellipse measures 17 x 11.5 cm and~displays a 1.0 cm centrally located everted nipple. No discharge or scar is noted.. The deep margin is inked in black. Serial sections reveal lobulated yellow. tan adipose tissue admixed with 10% moderately dense tan white fibrous tissue. The fibrous tissue is predominantly centrally located and shows. catted blue grey cysts measuring up to 0.4 cm in greatest dimension. No Page 2 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 Continued on Next Page
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+FOR ORFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: GROSS DESCRIPTION (continued) : Specimen #: discrete mass or lesion identified. No lymph nodes are identified.. Cassette summary: Al: skin A2: central A3: upper outer quadrant A4: lower outer quadrant A5: lower inner quadrant A6: upper inner quadrant. A7: upper outer quadrant. A8: lower outer quadrant A9: lower inner quadrant. A10: upper inner quadrant. All: representative section of nipple.. Matched sections of A1-A6 are submitted in ocr for cBcp protocol.. B. Received fresh labeled with the patient's name. designated "LEFT BREAST SHORT STITCH SUPERIOR, LONG LATERAL" is a 954 gram mastectomy specimen oriented with a short stitch superior and long lateral. The specimen measures 24 cm medial to lateral, 18 cm superior to inferior, and 6 cm anterior to posterior. The lightly pigmented superficial skin ellipse measures 19 x 12.5 cm and displays a medially located 1.5 cm everted nipple free of discharge. No scar is noted. The deep margin is inked black and the superficial lower outer quadrant is inked blue. Serial sections reveal 3.5 x 3.2 x 2.8 cm well defined lobulated pink white indurated mass with focal hemorrhage. The mass is located within the lower outer quadrant and comes within 3.5 cm of the deep margin and 0.4 cm' of"the inked superficial surface. The remainder of the specimen is composed of approximately 50% dense tan white fibrous. tissue which is diffusely nodular and focally cystic. The admixed adipose tissue is unremarkable. No additional masses are identified. No lymph nodes identified. Cassette summary:. B1: skin B2: lower outer quadrant mass B3: lower outer quadrant B4: upper outer quadrant B5: upper inner quadrant B6: lower inner quadrant B7: representative section of closest deep margin. B8-b9: representative sections of mass with closest point of approach to blue ink margin 10: representative section of nipple. locr. Page 3 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 Continued on Next Page
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+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION (continued): C. Received fresh labeled with the patient's name. designated SENTINEL LYMPH NODE #1" cOnsists of a 2.0 x 1.7 x 1.0 cm pink yellow fatty lymph node. The specimen is trisected. Two thirds of the lymph node are placed in cassette c1 and c2. Matched section of c1 is placed in for cBcp protocol. D. Received fresh labeled with the patient's name. designated "LEFT AxILLARy coNTENTs" consists of an unoriented irregular portion of adipose tissue measuring 9.0 x 9.0 x 2.0 cm. Sectioning reveals multiple pink yellow fatty lymph nodes ranging in size from 0.4 to 2.4 cm in greatest dimension. Cassette summary:. D1-D3: one lymph node each D4-D7: one lymph node bisected. D8: two lymph nodes bisected, one inked black. D9: four intact lymph nodes D10: one lymph node bisected D11: two lymph nodes D12: four possible lymph nodes. 12CF. E. Received fresh labeled with the patient's name. designated "NON SENTINEL CLINCALLY SUSPICOUS LEFT AXILLARY LIPH NODE" consists of a 1.7 x 1.5 x 1.3 cm lymph node. Cut surface is homogeneous and firm. A portion is submitted for frozen section. lC1 Page 4 FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 End of Report
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diff --git a/output/text/ebe51a4c-6963-4052-82ab-80fe551345d9.txt b/output/text/ebe51a4c-6963-4052-82ab-80fe551345d9.txt
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index 0000000000000000000000000000000000000000..df16114a7d32c7f7101709da14aa9ba7314e9cf4
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+UUID:577035B3-655D-401B-8316-308DE1970F66 TCGA-GC-A4ZW-01A-PR Redacted Report for TEST: Surgical Patholog Collected Date & TIme: Result Name Results Units Reference Range Surgical Pathology SURGICAL P SURGICAL PATHOLOGY REPORT Patient Name: Accession Med. Rec. #: Billing Type: Location: Service? Gender: Billing Taken Physician(s): ted Specimen(s) Received /cs-0-3 A: Distal right ureter B: Distal left ureter oarci oma WrrHlisl nos 81sof3 C: Bladder and prostate D: Right pelvic lymph nodes Sifk: b1oddw,n05 Cl7.9 E: Left pelvic lymph nodes. lw Pathologic Diagnosis "J41> Distal right ureter (A): Ureter segment, negative for dysplasia and malignancy. Distal left ureter (B): Benign ureter segment, negative for dysplasia and malignancy. Bladder and prostate, radical cystoprostatectomy (C): Invasive high-grade urothelial carcinoma (4.5 cm) invading through detrusor muscle into perivesical adipose tissue. Benign margins of surgical resection.. Negative for lymphovascular and perineural invasion. Lymph nodes (5), no tumor present.. Prostate with scattered microscopic foci of high-grade prostatic intraepithelial neoplasia; negative for involvement by transitional cell carcinoma. Unremarkable seminal vesicles, negative for involvement by urothelial carcinoma. Right pelvic lymph node (D):. Lymph node (1), no tumor present.. Left pelvic lymph nodes (E):. Lymph nodes (4), no tumor present. SURGICAL PATHOLOGY CANCER CASE SUMMARY CHECKLIST: BLADDER, RADICAL CYSTECTOMY Specimen: Bladder, prostate, bilateral seminal vesicles Procedure: Radical cystoprostatectomy Tumor Site:  Left anterior and posterolateral wall. Tumor Size: 4.5 cm Associated Epithelial Lesions: Papillary urothelial neoplasm
+
+--- Page 2 ---
+Page 2 of 4 high-grade Histologic Grade: who high-grade Tumor Configuration: Papillary for noninvasive elements and infiltrative for invasive elements Microscopic Tumor Extension: Perivesical fat Margins:  Uninvolved by invasive carcinoma Lymph-Vascular Invasion: Not identified Additional Pathologic Findings: None PATHOLOGIC STAGE: pT3a, pNO, pMX NoTe: Information on pathology stage and the operative procedure is transmitted to this Institution's Cancer Registry as required for accreditation by the Comaission on Cancer. Pathology stage is based solely upon the current tissue specimen being evaluated  Pathology stage is and does not incorporate other relevant data. only a component to be considered in determining the clinical stage and should not be confused with nor substituted for it. The exact operative procedure is available in the surgeon's operative report. Primar Clinical History Bladder cancer. Intraoperative Consultation.  Distal right ureter: Negative for carcinoma. (Microscopic A. evaluation). B. Distal left ureter: Negative for carcinoma. (Microscopic evaluation). D. Right pelvic lymph node: Benign lymph node. (Microscopic evaluation). Left pelvic lymph node: Negative for carcinoma. (Microscopic evaluation). Gross Description A.  Received fresh for frozen section labeled "distal right ureter" is a 0.5 x 0.3 x 0.1 cm segment of ureter. The specimen is inked yellow and entirely submitted in cassette Al-Fs. B. Received fresh for frozen section labeled "distal left ureter" is a 0.5 x 0.4 x 0.1 cm segment of ureter. The specimen is inked black and antirely submitted in cassette B1-Fs. C.  Received in formalin and labeled "bladder and prostate" is a 469 g, cystoprostatectomy specimen (15.0 x 13.0 x 6.0 cm). The specimen comes with an abundant amount of perivesicular adipose tissue attached. The cystoprostatectomy specimen consists of a bladder (6.5 x 5.5 x 5.0 cm) with attached right and left ureter (l.0 cm in length). There is a prostate (5.0 cm from left-to-right, 3.5 cm from anterior-to-posterior, 3.3 cm from apex-to-bladder-neck-margin) with attached right seminal vesicle (3.0 x 1.5 x 0.5 cm), right vas deferens (12.0 x 0.5 x 0.2 cm). left seminal vesicle (3.5 x 2.5 x 0.6 cm), left vas deferens (3.0 x 0.3 x 0.2 cm). The right side of the specimen is inked blue; the left side of the specimen is inked black. In the left anterior and posterior lateral wall of the bladder, there is a 4.5 x 2.5 x 0.9 cm pink-tan polypoid mass. This lesion extends across the midline into the right anterior and posterior bladder and extends towards the bladder-prostate junction. The
+
+--- Page 3 ---
+Page 3 of 4 mass' cut surface is white-tan, firm and extends into the perivesicular fat. The mass at the posterior bladder, comes to within 0.5 cm to the perivesicular fat margin (inked black) and on the anterior bladder is 1.0 cm from the perivesicular fat margin (inked black). The lesion is 2.5 cm from the nearest peritonealized surface. The ureteral orifices are patent. There are no other discrete masses or suspicious areas grossly identified. The remainder of the mucosa is tan, glistening and pliable. The prostate has a white-tan cut surface with no discrete nodules or masses grossly identified. There are 5 lymph nodes dissected out ranging from 0.3 to 1.1 cm in greatest dimension. Also received in the container is a 38 cm in length and 0.8 cm in. diameter, brown-tan rubber tubing consistent with a catheter. Sections are submitted as follows: cl - right trigone, c2 - left trigone, c3 - posterior bladder-prostate transition, C4 - anterior bladder-prostate transition, C5-9 - mass in left lateral posterior wall, clo - mass and lateral anterior wall, cll - right lateral wall, c12 - posterior wall, cl3 - anterior wall, cl4 -. dome, c15 - right seminal vesicle insertion point and cross-sections through right seminal vesicle and vas deferens, c16 - left seminal vesicle insertion point and cross-section through left seminal vesicle and vas deferens, c17-18 - right anterior apex perpendicularly cut, C19-20 - left apex anterior prostate, c23-25 - right posterior prostate, c26-28 - left posterior prostate, c29 - 5 lymph nodes ranging from 0.3 to 1.1 cm in greatest dimension. D. Received fresh for frozen section labeled "right pelvic lymph node" is a single lymph node measuring 4.0 cm in greatest dimension. The lymph node is serially sectioned and entirely submitted in cassette D1-FS and D2-Fs. E.  Received fresh for frozen section labeled "left pelvic lymph nodes" are 4 lymph nodes ranging from 1.3 to 5.5 cm in greatest dimension. Sections are submitted as follows: El-Fs and E2-FS contains one lymph node (5.5 cm) inked blue and serially sectioned, E3-Fs - two lymph nodes, one inked yellow, one inked black, E4-Fs and E5-Fs - one lymph node (5.0 cm) inked orange and bisected. Microscopic Description Microscopic examination has been performed on all slides. pathologic diagnosis encompasses the essential microscopic The findings of this case.. If immunohistochemistry or in situ hybridization was used the following applies: This test characteristic determined by ance It Administration (FDA). The FDA does not require this test to go through premarket FDA review. This test is used for clinical purposes. It should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLiA) as qualified to perform high complexity clinical laboratory testing.  All special stains
+
+--- Page 4 ---
+Page 4 of 4 used have adequate controls.
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diff --git a/output/text/ebee8756-60a9-4572-b509-6f4afa839a37.txt b/output/text/ebee8756-60a9-4572-b509-6f4afa839a37.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ce4e0f6c2aa60807aec6af0bfe462ba54914fbb7
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+
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+Pathology Report DIAGNOSIS (A) RIGHT KIDNEY, ADRENAL GLAND AND INFERIOR VENA CAVA: CHROMOPHOBE RENAL CELL CARCINOMA, FUHRMAN'S NUCLEAR GRADE 4 WITH EXTENSIVEI SARCOMATOID DEDIFFERENTIATION. (SEE COMMENT) TUMOR EXTENDS INTO THE PERINEPHRIC AND RENAL SINUS ADIPOSE TISSUE TUMOR EXTENDS INTO THE ADRENAL GLAND. TUMOR MEASURES 18 CM IN GREATEST DIMENSION TUMOR INVOLVES THE WALL OF THE RENAL VEIN/INFERIOR VENA CAVA AT THE MARGIN OF RESECTION (SEE COMMENT) Ureteral, renal artery and soft tissue margins of resection, free of tumor. Renal cortical (simple) cyst (2.2 cm in maximum dimension) COMMENT The tumor demonstrates extensive areas of sarcomatoid dedifferentiation composed of spindle cells with sheets of multinucleated giant cells. The sarcomatoid component comprises approximately 90-95% of the tumor. Although grossly the renal vein/inferior vena cava margin of resection appeared to be free of tumor, microscopically the tumor is involving the wall of the renal vein/inferior vena cava at the margin of resection. GROSS DESCRIPTION (A) RIGHT KIDNEY, ADRENAL GLAND, INFERIOR VENA CAVA - A nephrectomy specimen (22.0 x 15.4 x 8.0 cm) with attached adrenal gland (5.0 x 4.0 x 2.0 cm) and ureter (8.0 x 0.5 cm).  An 18.0 x 14.0 x 12.0 cm partially cystic, tan, necrotic, hemorrhagic tumor penetrates the renal capsule, extending into the. perirenal adipose tissue and appears to involve the attached adrenal gland. The tumor does appear to involve the renal sinus. The aforementioned cystic regions are filled with yellow mucinous material. No papillary excrescences or masses involve the cyst walls. The largest cystic area measures 3.9 cm in greatest dimension and has a thick tan corrugated wall. 3.0 cm away from the primary tumor is a simple 2.2 x 2.0 x 1.0 cm cortical cyst. This cyst is lined by thin unremarkable. lining. The distal ureter, renal vein, and renal artery margins are grossly uninvolved by tumor. However, upon opening the renal.  vein, the tumor expands and fills the proximal portion of the renal vein. INK CODE: Perinephric fat - blue SECTION CODE: A1, ureter, renal artery, renal vein margins; A2-A3, tumor and renal vein; A4-A8, cystic portions of mass; A9-A10, tumor in relationship to perinephric fat, blue ink; A11-A12, tumor in relationship to renal sinus; A13, tumor and normal; A14, tumor; A15-A16, tumor in relationship to adrenal gland; A17, tumor; A18, representative sections of benign cortical cyst; A19, representative sections of normal renal parenchyma; A20, additional section of the tumor; A21-A25, additional sections of the renal vein and hilum CLINICAL HISTORY Right renal mass. SNOMED CODES
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index 0000000000000000000000000000000000000000..bb9fcd3fbe0dc51d34fb8a0c51b52ad4c8229d83
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+--- Page 1 ---
+UUID:E7B0A3CF-35A3-433C-AF76-DB3E28DA6A46 Requesting Doctor's Information: TCGA-OR-A5JP-01A-PR Redacted 1 Deliver To LcD-o 3 Orcinsmo.-. , adreual sortico! 837013 .Site O Adrwas Clard,eon tex Received A C 74.D SPECIMEN TYPE: Adrenal T 36/3 H CLINICAL NOTES: 0 Non-functional left adrenal tumour. L MACROSCOPIC: 0 *Left adrenal gland'. The specimen consists of an adrenal gland, 504 g and 110 x 110 x 85 mm. The adrenal gland is largely replaced by a 100mm tumour. The G tumour is multinodular and has a variable cut surface with solid tan lobules, Y yellow/orange areas, and areas of haemorrhage, cystic change and necrosis. The tumour appears at least partially encapsulated and there is no macroscopic evidence of invasion. A small amount of uninvolved adrenal is identified at the periphery of the tumour. A1/A2 - Tumour with adjacent uninvolved adrenal gland. A3 - A6: Central tumour. A7 - A10: Tumour with overlying capsule. MICROSCOPIC: The left adrenal tumour is an adrenal cortical carcinoma (Weiss criteria). The tumour is composed of polygonal cells showing a predominantly diffuse, A sheet-like growth pattern with areas of myxoid degeneration which are divided N in areas by fibrous septa. The cells have abundant eosinophilic cytoplasm with a few scattered clear cells present. The nuclei are enlarged and pleomorphic A with coarse chromatin and prominent nucleoli. Mitoses are readily identified T (13/50hpt), including atypical forms, and there are broad areas of necrosis and haemorrhage. No vascular invasion is identified. While the tumour does extend 0 to the adrenal capsule it appears to be confined to the adrenal gland and local excision is complete. M Immunohistochemistry shows positive staining for inhibin,calretinin and Melan 1 A and negative staining for chromogranin. The rnorphological features and immunohistochemical protile are in keeping with c an adrenal cortical carcinoma. a SUMMARY: L Laft adrenal gland: Adrenal cortical carcinoma. STAGE: II(pT2, NX, MX). (AJCC Staging, 7lh Edition) P ADDITIONAL REPORT A The tumour has a Weiss score of 6. T Ki67 stains between 25-36% of tumour cells in the most proliferative areas. KdS. H 0 L 0 nf2
+
+--- Page 2 ---
+ Requesting Doctor's Information: A T SPECIMEN TYPE: Adrenal H 0 L 0 REPORTING PATHOLOGIS (iecuronic signature) G Y N A T 0 M 1 c A L Iw i|33[13 0 |Page 2 ot 2  0
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diff --git a/output/text/ebfbbdc3-cc5f-4141-8461-e2729943bfa9.txt b/output/text/ebfbbdc3-cc5f-4141-8461-e2729943bfa9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..48faba6e4404d2cecd60bb0d741b0fda8b30d3fa
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+--- Page 1 ---
+Page 1 of 3 UUID:E4ECB8AA-0ECC-47A5-B940-045A2C3D9A1A TCGA-Ew-A3E8-01A-PR Redacted Surgical Pathology Report Name: Case #: DOB: (Age. Collected: Gender: F Received: MRN: Reported: Location: Copy To: Physician: Pathologic interpretation: A. sentinel node count 0 axilla, fs: No malignancy seen in one lymph node (0/1). Immunohlstochemistry for keratin to follow. B. Sentinel node count 609 axillA, fs: No malignancy seen in one iymph node (0/1). Immunohistochemistry for keratin to follow. C. Left breast mastectomy single suture superior, Double suture medial:e INVAsIVE LOBULAR CARciNOMA, high nuclear grade, 7.0 cm (gross examination).. Prevlous blopsy site. No lymphovascular invasion identified. Jes-o- 3 Specimen margins are negative for tumor. hw iof3u1n  See Tumor Summary Sit: brast, Nus c5o.9 D. ADditional mastectomy skin: No malignancy seen. Pathology Cancer Case Summary Specimen: Total breast (including nipple and skin) Procedure: Total mastectomy (including nipple and skin) Lymph Node Sampling: Sentinel lymph nodes Specimen Integrity: Single intact specimen (margins can be evaluated) Specimen Laterality: Lent Tumor Site: Invasive Carcinoma: Upper outer quadrant Central Tumor Slze: Size of Largest Invasive Carcinoma: Greatest dimension of largest focus of invasion over 0.1 cm: 7.0 cm Tumor Focality: Single focus of invasive carcinoma Macroscopic and Microscopic Extent of Tumor: Skin: Invasive carcinoma does not invade into the dermis or epidermis Lobular Carcinoma in Situ (Lcis): Present Histologic Type of Invasive Carcinoma: Invasive lobular carcinoma Histologic Grade: Nottingham Histologic Score: Glandular (Acinar)/Tubular Differentiation  Score 3:  10% of tumor area forming glandulartubular structures Nudear Pleomorphism Score 3: Vesicular nuclel, often with prominent nucleoli, exhibiting marked variation in size and shape.
+
+--- Page 2 ---
+Page 2 of 3 occasionally with very large and bizarre forms Mitotic Count Score 1 Overall Grade: Grade 3: scores of 8 or 9 Margins:  Margins uninvolved by invasive carcinoma Lymph-Vascular Invasion: Not identified Lymph Nodes: Number of sentinel lymph nodes examined: 2 Number of lymph nodes with macrometastases (> 0.2 cm): 0 Method ot Evaluation ot Sentinel Lymph Nodes: Hematoxylin and eosin (H&E), one level Immunohistochemistry Pathologic Staging (pTNM): Primary Tumor(pT):  pT3: Tumor > 50 mm in greatest dimension Regionai Lymph Nodes (pN):  pNO: No regional lymph node metastasis identified histologically Distant Metastasis (pM): Not applicable Ancillary Studles: Estrogen Receptor: Pending Progesterone Receptor: Pending HER2/neu: Pending FDA approval. These clonee are ustd stsr r hy a 1D5=ERPgRG36=PRA485=HER2H-1=RFR.Al As the cattending pauthologist I attest thet I: (i) Examined the relevart prepcrction(s) for the specimen(s); and (ii) Rendered the diagnosis(es). Addendum Diagnosis A. sentinel node count o axilLa: Immunohistochemistry for keratin is negative. B. SentineL nOde count 609 AxIlLA: Immunohistochemistry for keratin is negative. C. Left sreast mastectomy single suture superior, double suture medial: The tumor cell are positive for ER (>90%) and PR (>90%) and negative for HER2 (0+) by immunohistochemistry
+
+--- Page 3 ---
+Page 3 of 3 Intraoperative Consuitation A. Sentinel node count 0 axilla, FS: No obvious malignancy. Final pending permanent section and perhaps IHC as original tumor was a lobular carcinoma.. B. Sentinel node count 609 axilla, FS: No obvious malignancy Final pending permanent section and perhaps IHC as original tumor was a lobular carcinoma.. Clinical History:. Biopsy proven multifocal carcinoma left breast. Please evaluate margins and if sentinel nodes are H&E (-), do serial sections and IHC Operation Performed Left total mastectomy, Sentinel node biopsy, possible axillary node dissection Pre Operative Diagnosis: Infiltrating lobular carcinoma left breast Specimen(s) Received: A: SEnTinel nODE COunt 0 AxILLA, fs B: SENTINEL NODE COUNT 609 AXILLA, FS C: LEFT BREAST MASTECTOMY SINGLE SUTURE SUPERIOR, DOUBLE SUTURE MEDIAL D: ADDITIONAL MASTECTOMY SKIN Gross Description: A. Received fresh labeled "Sentinel node count 0 axilla" is a tan piece of tissue measuring 2.5 x 2.0 x 0.3 cm. Submitted in toto in one cassette for trozen section. 8.  Received fresh labeled " Sentinel node count 609 axilla" is a piece of soft tissue with areas of adipose tissue that  measures 3.0 x 2.5 x 0.4 cm. Submitted in toto in one cassette for frozen section. C. Received fresh labeled "Left breast mastectomy, single suture superior, double suture mediar' is a one kelo left modified radical mastectomy that measures 18.0 x 12.0 x 6.0 cm. There is a white skin ellipse that measures 7.0 x 3.0 cm and a nipple that measures 1.8 cm in diameter. There are two sutures. The single suture is superior and the double suture is medial. The specimen is inked in black. Upon sectioning, there are diffuse areas of white nodularities throughout the parenchyma. There is a firm, white nodular lesion that extends 2.0 cm away from the lateral margin to the midline. It  measures 7.0 x 6.0 x 4.0 cm and it is 1.0 cm away from the deep margin, 4.0 cm trom upper margin, 5.0 cm from the  probably from a previous biopsy site that measures 6.0 x 5.0 x 3.0 cm. It is located 2.0 cm away from the superior margin, 1.5 cm from the deeper margin, 5.0 cm trom the inferior margin, 2.0 cm from the anterior margin. No other grossly identified.  There are 2/3 of stroma and 1/3 of adipose tissue. Sections submitted as follows:  lesions are Cassette #1 Nipple Cassettes #2-6  Several sections of tumor Cassette #7  Sections of tumor in relation to the superior margin Cassette #8 Deeper margin Cassette #9 Portion of retro-areolar area Cassettes #10&11 Superior inner quadrant Cassettes #12&13 Inferior inner quadrant Cassettes #14&15 Superior outer quadrant Cassettes #16&17 Inferior outer quadrant D.  Received in formalin labeled "Additional mastectomy skin" is an irregular piece of skin tissue measuring 14.0 x 7.0 x 1.2 cm. The specimen is white, pink and there were no abnormai lesions grossly identified. The specimen is not oriented. Representative sections are submitted in two cassettes Diagnosis
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new file mode 100644
index 0000000000000000000000000000000000000000..c0746c684fff355c4e85360fd7b82f8e0f0b757a
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+--- Page 1 ---
+Referring Physician:. UUID:52CEF542-0F58-4660-8746-2CF4A27B214E TCGA-AC-A3YI-01A-PR Redacted DOB: Age Gender. Ref#: Hosp#: Provider Group : Outpatient Case #: Date of Service: Date Received: Room. Date Reported: A copy of this report will be faxed to: FINAL SURGICAL PATHOLOGy REPORT Diagnosis: A. - D.) rIght breast and AxilLAry Lymph NoDes, Lumpectomy, SenTinel. LymPh NODE bIOPSy fOLLOWED bY LyMPh NODe DISSECTION: - Invasive lobular carcinoma, Nottingham grade 1-2. - Focal atypical ductal hyperplasia (ADH) and atypical lobular hyperplasia (ALH). - Metastatic carcinoma in twelve of thirteen axillary Iymph nodes (12/13, including all three sentinel lymph nodes). - Largest metastatic focus measures 1.1 cm in diameter. - Extranodal extension is identified in at least five Iymph nodes, with the largest focus of extranodal extension measuring up to 0.5 cm. - One sentinel lymph node (specimen B) shows evidence of having been previously biopsied.. - The lumpectomy margins are free of tumor. - Invasive carcinoma is 0.5 cm from the inferior margin, 0.8 cm from medial,. and is at least 1 cm from all other margins. PATHOLOGIC TUMOR STAGING SYNOPSIS:E Type and grade (invasive): Invasive lobular carcinoma, Nottingham grade 1. Primary tumor: pT1c. 1cD-0-3 cercinoma,1obusar, inF1 Hahng 85Z0J3 Regional lymph nodes: pN3a.. Distant metastasis: Not applicable.. 3ik: brcast,N0s c 5D.q 6-w1Z eA Stage: IIIC. Lymphovascular invasion: Indeterminate. Margin status: Negative.. crepancy Breast Invasive Tumor Stagina Information. (AJCC Cancer Staging Handbook,e) and CAP protocol, This staging also incorporates:. Previous biopsy Breast profile: Page 1 Case #: This report continues... (FiNAL) Printed: Phone Acct No. - Patient Na Page 1 Pathology Report - Page 1/5
+
+--- Page 2 ---
+Case #: Partial breast. Specimen type: Lumpectomy. Specimen procedure: Sentinel lympn node biopsies followed by axillary Lymph node sampling: lymph node dissection. Intact specimen. Specimen integrity: Right. Specimen laterality: 5.4 x 4.3 x 2.3 cm. Specimen size: INVASIVE TUMOR FEATURES: 1.8 cm. Invasive tumor size: 12:00. Invasive tumor site: Single focus invasive carcinoma. Invasive tumor focality: Invasive lobular carcinoma. Histologic type: 1 0f 3. Total Nottingham Grade: 3 of 3. Tubule formation: 1-2 of 3. Nuclear Pleomorphism: 1 of 3. Mitotic count for Nottingnam: One mitosis in ten high power fields.. Mitotic count: Indeterminate. Lymphatic invasion: Negative. MARGIN STATUS FOR INVASIVE COMPONENT: 0.5 cm. Distance of tumor from margins:. Inferior Closest margin: See diagnosis section. Other margins: Not identified. DUCTAL CARCINOMA IN-SITU (DCIS): Not identified. LOBULAR CARCINOMA IN-SITU (LCIS): Skin: Not applicable. Not applicable. Nipple: Not applicable. Skeletal Muscle: INVASIVE PATHOLOGIC TUMOR STAGING (pTNM) pT1c. Primary tumor (pT): Regional lymph nodes (pN): pN3a. Not applicable. Distant metastasis (pM): IHIC. Pathologic stage: RECEPTOR STATUS AND HER2/NEU: 98% positive cells. Estrogen receptors: 25% positive Progesterone receptors: IHC 1+. Her2/neu: 15% positive cells. Ki-67 proliferative index: Page 2 Case #: This report continues... (FiNAL) Printed Phone: Patient Name MR No. Acct No. : rage 2 Pathology Report - Page 2/5
+
+--- Page 3 ---
+Case #: FINAL SURGICAL PATHOLOGy REPORT athologist Signed by Source of Specimen: A. Breast lumpectomy:right B. Sentinel lymph node;right axillary C. Sentinel lymph node;right axillary. D. Right axillary dissection Clinical Historv/Operative Dx: Malignant neoplasm of right breast. Intraoperative Diagnosis:. B. Right axillary sentinel node. (with wire): Two lymph nodes, positive for metastasis.. One lymph node. positive for metastasis (Dr.'. ). The C. Right axillary sentinel node. intraoperative interpretation(s) was/were performed and rendered at. Gross Description: A. Specimen A is labeled right breast lumpectomy. Initially received in the fresh state for Oncogenotyping. studies is a 42 gram yellow-tan portion of fibrofatty soft tissue, 5.4 cm anterior-posterior, 4.3 cm  medial-lateral, 2.3 cm inferior-superior. A localizing guidewire impales the specimen through the. Superior-lateral periphery. Three sets of sutures are present designated as follows: two short - anterior, one Iong - medial, and two long - superior. The surgical margins are now differentially inked as follows:. SUPERIOR: BLUE Page 3 Case #: This report continues... (FINAL) Printed: Phone: Patient Na.... Acct No. - Page 3 Pathology Report - Page 3/
+
+--- Page 4 ---
+Case #: FINAL SURGICAL PATHOLOGY REPORT MEDIAL: RED ANTERIOR: YELLOW INFERIOR: GREEN LATERAL: ORANGE POSTERIOR: BLACK The specimen is serially sectioned perpendicularly through the anterior-posterior long axis to reveal a  partially demarcated, to ill-defined, dense, light gray tumor mass measuring up to 1.8 x 1.3 x 1.2 cm. The. lesion is grossly within 0.5 cm of the nearest inferior, 0.7 cm of the superior, 0.9 cm of the medial, 1.3 cm of the lateral, 0.9 cm of the posterior, and 1.7 cm of the anterior surgical margins. Representative portion of the tumor is submitted for Oncogenotyping studies. No biopsy site clips are appreciated. The remaining cut sections demonstrate soft to rubbery admixed, yellow-tan fibrofatty soft tissue without additional. discrete nodularity. Representative sections are submitted in a sequential fashion, posterior to anterior. Cassette summary: A1-A3) slab 1, posterior, A4-A7) slab 2, A8-A10) slab 3, A11-A13) slab 4, A14-A16) slab 5, A17-A19) slab 6, A20-A21) slab 7, margins trimmed and submitted, A22-A23) slab 8, margins, trimmed and submitted. A24-A25) slab 9, anterior margin represented. (with hookwire). Initially received in the B. Specimen B is labeled right axillary sentinel lymph node fresh state for frozen section analysis is a 4.7 x 4.2 x 1.5 cm portion of soft tissue. A localizing guidewire is present. Examination of the tissue reveals two lymph node candidates, 1.5 and 1.0 cm each. Both lymph nodes are serially sectioned and two touch preparation slides are forwarded for microscopic evaluation. The lymph node tissue is entirely submitted for microscopic evaluation in B1-B3. Cassette summary: B1-B2) largest lymph node, sentinel node protocol performed, 82) smaller tymph node,. sentinel lymph node protocol performed. Initially received in the fresh state for C. Specimen C is labeled right axillary sentinel lymph node frozen section analysis is a 3.5 x 3.0 x 0.5 cm portion of yellow-tan fatty soft tissue. Examination reveals a single 1.5 cm lymph node candidate. The cut surfaces are rubbery light pink to dense nodular light gray. A single touch preparation slide is forwarded for microscopic evaluation. The lymph node is entirely submitted for routine histology in C1.. D. Specimen D is labeled right axillary dissection. Received in formalin are two tattered pieces of fibrofatty soft tissue which measure in aggregate 14 grams and 6.4 x 4.7 x 1.7 cm. Examination reveals twelve lymph node candidates ranging from 0.2-0.9 cm. The larger lymph nodes demonstrate a palpable firm-nodular architectures. Lymph node tissue candidacy is entirely submitted for microscopic evaluation. Page 4 Case #. This report continues... (FINAL). Printed: Phone Patient Nt Patholoay Report - Page 4/5.
+
+--- Page 5 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT Cassette summary: D1) four lymph node candidates, D2) two lymph node candidates, D3) two lymph node candidates, D4) four lymph node candidates.. Microscopic Description: invasive lobular carcinoma. Appropriate positive and negative. A. Immunohistochemical stain:. controls reviewed. 8. Immunohistochemical stains:. , nighlighting metastatic carcinoma and extranodal extension.. Appropriate positive and negative controls reviewed. C. Immunohistochemical stains: :.  highlighting metastatic carcinoma and extranodal extension.. Appropriate positive and negative controls reviewed.. D. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis. rendered. Page 5 Case #: END OF REPORT (FINAL) Printed: Phon Patient Nan Patholoay Report - Page 5/5
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diff --git a/output/text/ec059d5c-63d1-42d2-a8e1-0443c03a2fb7.txt b/output/text/ec059d5c-63d1-42d2-a8e1-0443c03a2fb7.txt
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index 0000000000000000000000000000000000000000..c8dae379526b69dce2e725ab1210c16a87abf596
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+--- Page 1 ---
+UUID:A323FD5A-1C3E-49D3-A7EA-04E3663D6883 TCGA-PK-A5H9-01A-PR Redacted LABORATORY MEDICINE PROGRAI zcD-o-3 arcinomo, Adrenal Cortica! 837013 Advenol C land ,Cortex 3 e74D JtO r/8113 Surgical Pathology Consultation Report. Patient Name: Accession #: MRN: Service: Collected: DOB: Visit #: Received: Gender: Location: Reported: HCN: Facility: Ordering MD: Copy To: Specimen(s) Received 1. Adrenal: ADRENAL MASS WITH ADRENAL GLAND 2. Gallbladder 3. Surgical Waste 4. Liver: Liver segment 5 Diagnosis 1. Angioinvasive low grade adrenal cortical carcinoma, 10.0 cm: Adrenal (side not specified) adrenalectomy specimen.. See Comment and Microscopic Description. 2. No pathological diagnosis: Gallbladder, cholecystectomy specimen. 3. No pathological diagnosis: Fibroadipose tissue, (site listed as "surgical waste") excision.. 4. Focal nodular hyperplasia; no evidence of metastatic disease; macrovesicular steatosis (10%): Liver (segment 5),. segmentectomy specimen. See Microscopic Description. Comment The mitotic activity is very low (2/5ohpr); the presence of angioinvasion, atypical mitosis, increased p53 expression. (15%), paucity of clear cells and diffuse architecture are consistent with an angioinvasive low grade adrenal cortical carcinoma. The adrenal tumor has been seen in consultation with. and they agree with the interpretation. and diagnosis. Synoptic Data Tumor Site: Adrenal structure Adrenal Gland Received: Fresh Procedure: Adrenalectomy, total Specimen Integrity: Intact Specimen Size: Greatest dimension: 11.5 cm Additional dimension: 8.2 cm. Additional dimension: 5.8 cm. Specimen Laterality: Other: Right side based on imaging. Tumor Size: Greatest dimension: 10.0 cm. Additional dimension: 5.7 cm Additional dimension: 5.2 cm Page 1 of 3
+
+--- Page 2 ---
+Surgical Pathology Consultatlon Report. Tumor gland weight: 156 g Histologic Type: Adrenal cortical carcinoma Margins: Margins uninvolved by tumor Tumor Description: Invasion, Vessels Lymph-Vascular Invasion: Present Perineural Invasion: Not identified Lymph Nodes, Extranodal Extension:. Not identified TNM Descriptors: Not applicable Primary Tumor (pT): pT2: Tumor greater than 5 cm, no extra-adrenal invasion Regional Lymph Nodes (pN): pNX: Cannot be assessed Number of Nodes examined: 0 Number of Nodes involved: 0 Distant Metastasis (pM): Not applicable Additional Pathologic Findings: Degenerative changes, Hemorrhage Other: Nontumorous adrenal with lipid depletion consistent with stress effect Liver segment 5 resection with focal nodular hyperplasia. *Pathologic Staging is based on AJCC/UICC TNM, 7th Edition Electronicallv verified by: Gross Description 1. The specimen labeled with the patient's name and as "adrenal mass with adrenal gland", contains a tan fatty grossly enlarged adrenal gland which is received fresh. The specimen weighs 290.9 g in the fresh state. The specimen has overall measurements of 11.5 x 8.2 x 5.8 cm. The surrounding fat is removed and the adrenal gland weighs 156 g. At specimen preparation, the specimen has not been painted prior to sectioning. Sectioning of the specimen reveals a distorted tan-yellow adrenal gland measuring 10.0 x 7.0 x 5.2 cm. Adjacent to the adrenal gland is a solid and partially cystic tan hemorrhagic mass which measures 10.0 x 5.7 x 5.2 cm. There is a tan-white fibrous capsule over the surface of the mass measuring 0.1 cm in thickness. Photographs are taken. Representative tissue is submitted frozen.. Representative tissue is submitted for electron microscopy.. 1A-T  multiple representative sections of mass including adrenal gland and capsule. Additional blocks 1U- 1AL additional representative sections of the mass. 2. The specimen labeled with the patient's name and as "gallbladder", contains a gallbladder that is unremarkable. It measures 6.0 cm long, with an open circumference of 4.8 cm, and an average wall thickness of 0.2 cm. It contains green bile, no gallstones are grossly identified. The duct is patent. The cystic duct lymph node is not grossly identified.. 2A representative sections submitted 3. The specimen labeled with the patient's name and as "surgical waste", contains 1 piece of tissue in 10% buffered formalin. The tissue consists of a fragment of adipose measuring 4.5 x 4.0 x 2.0 cm. No gross abnormalities are. identified. 3A-3B representative sections submitted 4. The specimen container is received labeled with the patient's name and as "liver segment 5". The specimen consists of a segment of liver, received fresh with a weight of 132.2 g. The capsule is pale tan and smooth except for two areas, a linear area defect measuring 5-cm length which is consistent with cautery and a dark tan spot on the surface measuring 1.2 cm diameter which is adjacent to the tumor mass. The surgical excision margin is painted with green ink. The cut surface demonstrates a single tan fibrotic mass as follows: Nodule #1. 1.8 x 1.0 x 0.9 cm: Distance from margin: 1.1cm. There is no large vessel invasion or extrahepatic extension. The hilar vessels and ducts, and the hepatic vein outflow tracts cannot be identified. There is no gallbladder grossly identified. Page 2 of 3
+
+--- Page 3 ---
+Surgical Pathology Consultation Report  Representative tissue is stored frozen Photographs are taken. Representative sections: 4A Mass with inked excision margin 4B-4C further representative sections of mass 4D section a cauterized capsular surface 4E representative section of background liver away from mass. ADDITIONAL BLOCKS: 4F-4H remainder of the mass and liver directly adjacent to mass submitted in toto. Microscopic Description 1. The tumor is an encapsulated 10.0 cm neoplasm which arises from the adrenal (slide 1F). The tumor shows a paucity of clear cells and diffuse architecture. The mitotic rate is low (2/50 HPF) but atypical mitoses, including 'tripolar figures" are identified (slide 1E).There is no unequivocal evidence of capsular invasion. However, angioinvasion, with tumor cells associated with thrombus inside vascular channels, is identified (slide 1AK). There is no necrosis, and no high grade Fuhrman nuclei. The tumor appears to be completely excised. Histopathological summary: 1. High nuclear grade (Fuhrman criteria): ABSENT 2. >5 mitoses per 50 HPF: ABSENT 3. Atypical mitotic figures: PREsENT 4. <25% of tumor cells are clear cells: PRESENT 5. Diffuse architecture: PRESENT 6. Necrosis: ABSENT 7. Venous Invasion: PRESENT (Tumor cells associated with thrombus; slide 1AK) 8. Sinusoidal Invasion: ABSENT 9. Capsular Invasion: ABSENT 10. Immunohistochemistry: The tumor stains positive for SF-1, and AE1/AE3 cytokeratin. It shows variable positivity for. low molecular weight cytokeratin (CAM5.2), and p53 (up to 15% of tumor). The tumor is negative for EMA, chromogranin, HEPAR-1, and vimentin. Beta catenin shows regional loss of membranous staining. The MiB-1 proliferation marker stains 5% of tumor cells. The overall morphological and immunohistochemical features are those of a low grade adrenal cortical. carcinoma. 4. The liver shows a solitary benign hepatocellular lesion composed of hepatocytes with normal N/C ratio, traversed with. fibrous septa containing large vessels, mild lymphoid infiltrate and ductular reaction. The features are those.of focal nodular hyperplasia. The lesion is negative for SF-1. CK7 stains the bile ductular reaction. CD34 shows patchy staining of sinusoidal endothelial cells around fibrous septa, consistent with focal nodular hyperplasia. There is no evidence of metastatic disease. The background liver shows no fibrosis (trichrome). There is mild macrovesicular steatosis (10%). PASD shows no evidence of alpha-1 antitrypsin globules. Iron staining is negative, The liver was seen in consultation with (liver pathology), and she agrees with the interpretation and diagnosis. 4/13 Page 3 of 3
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index 0000000000000000000000000000000000000000..2af2ee1ca4437c56d1762ab33ee99612b23a2d10
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+UUID:F4B87B89-A066-4BE9-88C9-60C7FB5BF373 TCGA-S3-AA14-01A-PR Redacted MRN: Sex/DOB: Female  Patient: Admission Date: Discharge Date: Ordering Physician: Surgical Pathology Report... Collected Date/Time: Accession Number: Received Date/Time: Final Diagnosis A. L YMPH NODES, RIGHT SENTINEL, EXCISION: - THREE OUT OF FOUR LYMPH NODES SHOW ONE TO TWO POSITIVE TUMOR CELLS BY CYTOKERATIN STAIN, pN0 (i+) - SEE SPECIAL STAINS SECTION BELOW. B. BREAST, RIGHT, EXCISION WITH NEEDLE WIRE LOCALIZATION: - INVASIVE DUCTAL CARCINOMA, GRADE 3, NOTTINGHAM HISTOLOGIC SCORE 8 (TUBULE FORMATION 3, NUCLEAR PLEOMORPHISM 3, MITOTIC RATE 2). - DUCTAL CARCINOMA IN SITU, GRADE II-III, SOLID AND CRIBRIFORM TYPES WITH SMALL AREAS OF NECROSIS. - LOBULAR CARCINOMA IN SITU, PLEOMORPHIC AND CLASSICAL TYPES. ZCD-0-3 - LYMPHOVASCULAR INVASION PRESENT. SEE NOTE. - SEE SPECIAL STAINS SECTION BELOW. - SEE ALSO SYNOPTIC REPORT. J8 sof3 NOTE:  B. There is a focus of lymphovascular invasion that is 0.2mm from the anterior margin. ytO &JQ 41s4 (Electronic signature) Veritied: Synoptic Report SPECIMEN: Partial breast PROCEDURE:  Excision with wire-guided localization LYMPH NODE SAMPLING: Sentinel lymph node(s) SPECIMEN INTEGRITY: Printed by: Page 1 of 5 Print Date/Time: Copied to: Distribute to: Patient Locations:
+
+--- Page 2 ---
+MRN: Patient: Sex/DOB: Female Surgieal Pathology Report Collected Date/Time: Accession Number: Received Date/Time: Single intact specimen (margins can be evaluated) SPECIMEN SIZE: Greatest dimension: 5.0 cm Additional dimensions: 4.0 x 3.5 cm SPECIMEN LATERALITY: Right TUMOR SITE: INVASIVE CARCINOMA: Not specified TUMOR SIZE: SIZE OF LARGEST INVASIVE CARCINOMA: Greatest dimension of largest focus of invasion over 0.1 cm: 2.0 cm (Based on gross evaluation) Additional dimensions: 2.0 x 1.8 cm TUMOR FOCALITY: Single focus of invasive carcinoma MACROSCOPIC AND MICROSCOPIC EXTENT OF TUMOR: Skin: Skin is not present Skeletal Muscle: No skeletal muscle present. DUCTAL CARCINOMA IN SITU (DCIS): DCIS is present Extensive intraductal component (EIC) negative SIZE (EXTENT) OF DCIS: Number of blocks with DCIS: 19 Number of blocks examined: 29 ARCHITECTURALPATTERNS: Cribriform Solid NUCLEAR GRADE: Grade III (high) (DCIS is mostly Grade II ) NECROSIS: Present, focal (small foci or single cell necrosis) LOBULAR CARCINOMA IN SITU (LCIS): Present (Pleomorphic and classical types) HISTOLOGIC TYPE OF INVASIVE CARCINOMA: Invasive ductal carcinoma (no special type or not otherwise specified) (With a minor component of apocrine differentiation) GLANDULAR (ACINAR)/TUBULAR DIFFERENTIATION: Score 3: <10% of tumor area forming glandular/tubular structures NUCLEAR PLEOMORPHISM: Score 3: Vesicular nuclei, often with prominent nucleoli, exhibiting marked variation in size and shape, occasionally with very large and bizarre forms MITOTIC COUNT: Score 2 OVERALL GRADE: Grade 3: scores of 8 or 9 MARGINS: Margins uninvolved by invasive carcinoma Distance from closest margin: 1.6 mm (Anterior margin) Page 2 of 5 Print Date/Time:
+
+--- Page 3 ---
+MRN: Patient: Sex/DOB:  Female Surgical Pathology Report Collected Date/Time: Accession Number: Received Date/Time: Margins uninvolved by DCIS (if present) Distance from closest margin: 1.2 mm (Anterior margin) TREATMENT EFFECT: RESPONSE TO PRESURGICAL THERAPY: IN THE BREAST:  No known presurgical therapy TREATMENT EFFECT: RESPONSE TO PRESURGICAL THERAPY: IN THE LYMPH NODES:S No known presurgical therapy LYMPH-VASCULAR INVASION: Present DERMAL LYMPH-VASCULAR INVASION: Not identified LYMPH NODES: Number of sentinel lymph nodes examined: 4 Total number of Iymph nodes examined (sentinel and nonsentinel): 4 Number of lymph nodes with macrometastases (>0.2 cm): 0 Number of Iymph nodes with micrometastases (>0.2 mm to 0.2 cm and/or >200 cells): 0 Number of lymph nodes with isolated tumor cells (less than or equal to 0.2 mm and less than or cqual to 200 cells): 3 EXTRANODAL EXTENSION: Not identified METHOD OF EVALUATION OF SENTINAL LYMPH NODES: H&E, multiple levels Immunohistochemistry PRIMARY TUMOR (INVASIVE CARCINOMA (pT): pT1c: Tumor >10 mm but less than or equal to 20 mm in greatest dimension REGIONAL LYMPH NODES (pN): pN0 (i+): Malignant cells in regional lymph node(s) no greater than 0.2 mm and no more than 200 cells (detected by H&E or IHC including ITC) (pN0 (i+) DISTANT METASTASIS (M): Not applicable ADDITIONAL PATHOLOGIC FINDINGS: Intraductal papilloma (3.5 mm), fibrocystic changes, usual ductal hyperplasia, reactive changes at prior biopsy site. ESTROGEN RECEPTOR: Performed on another specimen Specimen (accession number): Immunoreactive tumor cells present (greater than or equal to 1%) Quantitation: 75%, positive PROGESTERONE RECEPTOR: Performed on another specimen Specimen (accession number): Immunoreactive tumor cells present (greater than or equal to 1%) Quantitation: 75%, positive HER2/NEU IMMUNOPEROXIDASE STUDIES: Performed on another specimen Specimen (accession number): Positive (Score 3+) MICROCALCIFICATIONS:  Present in both carcinoma and non-neoplastic tissue Page 3 of 5 Print Date/Time:
+
+--- Page 4 ---
+MRN: Patient: Sex/DOB: Female Surgical Pathology Report. Collected Date/Time: Accession Number: Received Date/Time: Source of Specimen  Lymph Nodes, Sentinel Right Axillary B RT. BREAST TISSUE Clinical Information  markings: double long-12:00, single long-6:00, double short-deep PRE-OP DIAGNOSIS: Right breast cancer POST-OP DIAGNOSIS: Same T'YPE OF PROCEDURE: Right breast needle localization biopsy and right Sentinel node biopsy. Gross Description Specimen is received in 2 parts: A.The specimen is labeled "RIGHT SENTINEL NODE" and is received unfixed. It consists of 4 x 4 x 1 cm fragment of fatty tissue which reveals 6 lymph nodes ranging from 0.5 x 0.5 x 0.3-2 x 1 x 1 cm. All lymph nodes are entirely submitted as follows: A1 = possible two lymph nodes A2 -- bisection of a single lymph node A3-A4 = entire sections of single lymph node Specimen is in formalin more than 6 hours and less than 48 hours Time specimen was removed from the patient: Time specimen was placed in formalin :. Ischemic time: 16 minutes. B. The specimen labeled "RIGHT BREAST TISSUE" is received in formalin. (Specimen is in formalin more than 6 hours and less then 48 hours). It consists of an ovoid piece of yellow-tan fatty tissue with 3 sutures designating double long - 12 o'clock, single long - 6 o'clock and double short - deep margin. A ncedle guide wire is inserted within the specimen.. The specimen measures 5 x 4 x 3.5 cm, is oriented and inked as follows: Anterior-yellow, posterior-black, superior-orange, inferior-red, medial-blue, and lateral margin with green color. On sectioning, the cut surface shows centrally, a 2 x 2 x 1.8 cm in ill-defined mass with 0.5 x 0.5 x 0.5 cm calcification. Entirely submitted in cassettes B1-B29. Time specimen was removed from the patient: Time specimen was placed in formalin : Ischemic time: One hour 4 minutes. Dictated by: Special Stains / Slides Immunohistochemical studies were performed on formalin fixed, paraffin-embedded tissue (Block s A1, A2, A3 & A4) with adequate positive and negative control sections. A1 and A2 each shows a single positive cells, A3 reveals 2 positive cells and A4 is entirely negative. Immunohistochemical stains were also performed on B18 with appropriate positive and negative controls. The results are as follows: B18- E-cadherin : Pleomorphic LCIS shows speckled pattern Page 4 of 5 Print Date/Time:
+
+--- Page 5 ---
+MRN: Patient: Sex/DOB: Female SurgiealPathology Reports Collected Date/Time: Accession Number: Received Date/Time: p63: Present in the pleomorphic and classical LCIS; negative in DCIS-like areas and invasive ductal carcinoma, the former mostly representing lymphovascular invasion . Calponin: Present in the pleomorphic and classical LCIS; negative among neoplastic cells within the lymphovascular space. Podoplanin: Highlights lymphovascular invasion. The porformance characteristics of these antibodies were determined by the. They have not been cleared or approved by the U.S. Food and Drug Administration. The FDA has dotermined that such. clearance or approval is not necessary. These tests are usod for clinical purposes. They should not be regarded as investigational or for rescarch. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 198s (CLIA-88) as qualified to parform high-complexity clinical laboratory testing. 37 H&E, 8 IHC Tissue Code h 1anf3 JALIFIE Page 5 of 5 Print Date/Time:
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diff --git a/output/text/ec192d14-9b98-445c-966c-350dc9f250d4.txt b/output/text/ec192d14-9b98-445c-966c-350dc9f250d4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ba5bdadcc1c5dd46732986a30b868782009113cf
--- /dev/null
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+--- Page 1 ---
+UUID: 554C324B-C9C3-4936-B5E4-B3541A54364D0 Department of Pathology TCGA-P4-A5E6-01A-PR Redacted Tissue Source Site (TSS) #: Patholgy Accession No: Patient ID: Normal Sample ID: Pathology Report t<D-o-3 COMMENT rencd eel 8QsJ3 This addendum report is issued to comment on the type of papillary renal cell carcinoma, as it was not mentioned in the original report. There is no other change in diagnosis.. DKidnty NOS Site After review of the H&E slides, this tumor is designated as type 2 papillary renal cell. Cb4 carcinoma. nS 1J1c/13 DIAGNOSIS (A) LEfT 12Th RiB: Segment of rib, for gross inspection only. (B) LEFT KIDNEY AND ADRENAL: PAPILLARY RENAL CELL CARCINOMA, FUHRMAN'S NUCLEAR GRADE 3.S TUMOR CONFINED TO THE KIDNEY. TUMOR MEASURES 6.5 CM IN MAXIMUM DIMENSION. Vascular ureteral and soft tissue margins of resection free of tumor. Multiple renal cortical adenomas (0.3 cm in maximum dimension).  Multiple renal cortical (simple) cysts (5.0 cm in maximum dimension). Adrenal cortical hyperplasia. (C) HILAR LYMPH NODES: METASTATIC PAPILLARY RENAL CELL CARCINOMA IN ONE OF THREE LYMPH NODES. (SEE COMMENT) COMMENT The metastatic focus in one lymph node consists of a few clusters of neoplastic cells in the subcapsular sinus and measures less than 0.1 cm in maximum dimension. Multiple additional deeper sections were examined. GROSS DESCRIPTION (A) LEFT 12TH RIB, GROSS ONLY - A tan-pink linear fragment of bone (6.0 x 1.5 x 0.6 cm). The specimen is submitted as gross only.. (B) LEFT KIDNEY AND ADRENAL - A left radical nephrectomy (24.0 x 10.0 x 7.0 cm) consisting of a kidney (14.0 x 0.5 x 7.0 x 6.5 cm) and adrenal. gland (8.0 x 3.0 x 2.5 cm). Within the mid portion of the kidney is a well circumscribed soft friable mass (6.5 x 5.5 x 5.5 cm). The tumor pushes against the perirenal adipose tissue but does not appear to invade it, the tumor also pushes against the renal pelvis but does not appear to invade. The. tumor does not appear to invade the renal vein..  The uninvolved kidney parenchyma is remarkable for several cysts ranging size from 0.5 to 5.0 cm in greatest diameter. They are mainly. Iocated in the cortex. Also present are approximately seven yellow nodules, all of which measure (<0.3 cm in greatest dimension). The adrenal gland is remarkable for a large nodule and diffuse enlargement.. A portion of tumor and kidney is submitted to the tissue bank.. SECTION CODE: B1, renal artery vein and ureter margin; B2, tumor in relation to renal pelvis; B3, tumor in relation to renal pelvis; B4, tumor in relation to renal pelvis and adjacent kidney; B5, tumor in
+
+--- Page 2 ---
+Department of Pathology. Tissue Source Site (TsS) #:. Patholgy Accession No:. Patient ID. Normal Sample ID: Tumor Sample ID: relation to the kidney; B6, tumor in relation to perirenal adipose. tissue and renal capsule; B7-B8, representative sections of tumor; B9-B12, representative sections of yellow nodules throughout parenchyma B13-B17, representative sections of cyst; B17-B19, representative sections of adrenal gland.. (C) HILAR LYMPH NODES - A tan-pink irregular portion of adipose tissue (5.5 x 1.5 x 1.0 cm). The specimen is serially sectioned and multiple. lymph nodes are identified ranging in size from 0.5 x 0.5 x 0.3 to 1.5 x 1.0 x 0.6 cm). The lymph nodes are submitted in toto. SECTION CODE: C1, two lymph nodes; C2, one lymph node bisected. CLINICAL HISTORY Left renal mass. SNOMED CODES T-71000, M-Y7343, T-C4600, M-Y7346
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diff --git a/output/text/ec5bbfff-bef7-480f-aef7-c7020c3535bf.txt b/output/text/ec5bbfff-bef7-480f-aef7-c7020c3535bf.txt
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index 0000000000000000000000000000000000000000..7de3f1038bdb645dcf0807e0b1c94e94b0a6e90a
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+
+--- Page 1 ---
+t0DO3 8260|3 UUID:6B3A5E0D-BFF2-4386-A9F9-1DB99DEDC3F3 TCGA-5P-A9K6- Redacted JsJ 6/13/14 Papillary Renal Cell Carcinoma, Type I, moderately differentiated. The tumor presents as a multi-focal one. Stage: pT1a (multifocal), RO Grade: GII ICD-0-Code: 8260/3 Laterality = (e) h 5//y
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diff --git a/output/text/ec5c51f5-c6fe-4dcd-8a90-3b64277a4a93.txt b/output/text/ec5c51f5-c6fe-4dcd-8a90-3b64277a4a93.txt
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index 0000000000000000000000000000000000000000..167e19568b7fc5bfac7e5e2abb77be499d9d8b30
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+--- Page 1 ---
+UUID:794A5996-F823-400F-A67E-B0119DCD38B4 TCGA-UN-AAZ9-01A-PR Redacted SURGICAL PATHOLOGY REPORT Date Reported: SPECIMEN(S) RECEIVED LEFT KIDNEY FINAL DIAGNOSIS IeD 0-3 LEFT KIDNEY: C'arunwnx, yoapullary renal oelL 8Qitk3 Procedure: Radical Nephrectomy Site:O4iday NdS ci4.q Specimen laterality: Left AJ H/8oJ74y Tumor Site: Upper pole Tumor Size: Greatest dimension: 6 cm. Additional dimensions: 5 x 3 cm. Tumor Focality: Unifocal Macroscopic Extent of Tumor: Tumor limited to kidney Histologic Type: Papillary renal cell carcinoma Histologic Grade (Fuhrman Nuclear Grade): G2: Nuclei slightly irregular, approximately 15 m; nucleoli evident Microscopic Tumor Extension: Tumor limited to kidney Margins: Margins uninvolved by invasive carcinoma Lymph-Vascular Invasion: Not identified Pathologic Staging (pTNM) Primary Tumor (pT) pT1b:  Tumor more than 4 cm but not more than 7 cm in greatest dimension, limited to the kidney Regional Lymph Nodes (pN) pNO: No regional lymph node metastasis Specify: Number examined: 0. Number positive: 0. Distant Metastasis (pM) Not applicable AJCC Pathologic Stage (7th Edition): (pT1b, pN0) Pathologic Findings in Nonneoplastic Kidney: Page 1 of 2
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORTS Glomerular disease (specity type): glomerular sclerosis Tubulointerstitial disease (specity type): chronic intersttial nephritis. *** Report Electronically Signed **** CLINICAL DIAGNOSIS AND HISTORY Left renal mass GROSS DESCRIPTION The specimen is received fresh in a single container labeled with the patient's name, medical record number, and Identified as "Left Kidney". The specimen consists of a left kidney weighing 286.2 grams and adjacent perirenal fat measuring 15 x 6.5 x 5.5 cm. The  specimen is bivalved to show a disrupted tumor measuring approximately 6 x 5 x 3 cm with crumbling papilary pieces in the upper  pole ot the kidney. Note: On imaging this mass measured up to 6.7 cm in greatest cranial caudai dimension. The mass clearly. disrupts the capsular surface at the upper pole. The mass is kocated 0.7 cm from the renal pelvis and does not appear to invade the pelvic structures. The remainder of the renal cortex is tan-brown with a well-defined cortical medullary junction. The renal cortex measures 0.6 cm in thickness and the medulla measures 1.5 cm in thickness. The pelvis and calyces are covered by smooth glistening mucosa. The adipose tissue is thinly sectioned and no lymph nodes are found. The specimen is submitted in cassettes as follows: 1and 2- tumor and areas of necrosis, 3- tumor with capsule (3 fragments), 4 and 5- tumor with adjacent  normal renal parenchyma, 6- pelvic structure margins, 7- tumor near renal parenchyma, 8 and 9- sections of unremarkable kidney parenchyma, and 10- perirenal fat. The specimen ls submitted representatively in ten cassettes. Dictated by: Dual/Synchronous Prin Case is (circie) P4 By the signature above, the senior pathologist certifies that s/he personally conducted the evaluation of the described specimen(s) and rendered the diagnosis(es) related thereto. Page 2 of 2
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diff --git a/output/text/ec6a24db-e477-4739-98b2-8eddfa87102e.txt b/output/text/ec6a24db-e477-4739-98b2-8eddfa87102e.txt
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index 0000000000000000000000000000000000000000..d437512023202ebd0bbf71e986d34eb10e0cf7cd
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+--- Page 1 ---
+Collection Date: FINAL DIAGNOSIS: ICDO-Z PaRt 1: LEft AxIllA, SenTinel Lymph nOde #1, eXciSiOn - ONe Lymph NODe, POSITIVE fOR MeTASTaTIC CARcINoma (1/1). PARt 2: LEft AXiLLA, SEnTinel Lymph nODE #2, EXcISiOn -- No s One Lymph node, positive for metastatic carcinoma (1/1). PART 3: LEFT AXILLA, SENTINEL LymPh NODE #3, EXcISiON -- Sute DYusst Nos 509 One Lymph node, positive for metastatic carcinoma (1/1). Part 4: left nipple, posterior, biopsy -- YtJ n|z4|13 A.  ATYPICAL LoBULAR hypERPLASiA. B. nO InVaSIVE CArCInOmA PRESENT. Part 5: Left sreast, nipple Sparing mastectomy - A.  INVASIVE LOBULAR CARCINOmA, CLASSICAL TYPE, 2.5 X 1.5 X 1.2 CM ASSOCIATED WITH MICROCALCIFICATIONS. B.  NOTTiNghAm GRADE 2 (tuBULES 3, nUCLEAR PLEOmOrPhISm 2, mITOTIC ACTIVITy 1; tOTaL SCORe 6/9). C. LOBuLAR CARcinOmA in-SItu (LCiS) wIth PagetOiD EXTensiOn intO Oucts AnD AsSOciaTED MICROCALCIFICATIONS. D.  NO Lymphovascular SPace invasiOn IdentIfieD. E. SURGICAL MARGINS NEGATIVE. F. iNVASIVe TUmOR IS 0.3 CM FROM AnTERIOR mARGIN.E G.  inVASive tUmOr is LOcated aT JuNcTiOn betWEen Upper/OuTER AnD uppeR/InNEr qUADrAnTS. H.  SuBareOlar tissue involVed sy Lcis, but negative for InvasIve CarcinomA. CHANGES CONSISTENT WITH PREVIOUS CORE BIOPSIES ( FiBROCYSTIC CHANGES WITH FOCAL APOCRINE METAPLASIA. K. FIBROADENOMATOUS CHANGES L UNREMARKABLE SKELETAL MUSCLE. M. BENiGN EPITHELIAL CALCIFICATIONS. N. The invasive tumOr ceLls were Reported tO be POsitive fOr eStrOgen REceptOrs, pOsiTive fOR PrOgeSTerONe RECEpTORS, AND NEgATIVe fOR hER-2, wiTH A KI-67 PrOUFERATIOn InDEX Of 1%, AS pEr preViOUs pathOLOgy repOrt?E CASE SYNOPSIS: SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST LATeRa: ITy: Left PROCEDURE: Simple mastectomy LOCATION: Upper outer quadrant Upper inner quadrant SIZE OF TUMOR:  Maximum dimension invasive component: 25 mm MULTICENTRICITYAMULTIFOCALITY OF INVASIVE FOCI: No TUMOR TYPE (invasive component): Infiltrating lobular carcinoma HISTOLOGIC TYPE: Classical UUID:22134EA5-5ED5-47B8-9A33-01E59E58854C0 tcga-bh-A8g0-01a-PR Redacted NOTTINGHAM SCORE: Nuclear grade: 2 Tubule formation: 3 Mitotic activity score: 1 Totai Nottingham score: 6 Nottingham grade (1, 2, 3): 2 ANGIOLYMPHATIC INVASION: No DERMAL LYMPHATIC INVASION: Not applicable CALCIFICATION: Yes, benign zones Yes, malignant zones TUMOR TYPE, IN SITU: LCIS SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No Distance of invasive tumor to closest margin: 3 mm SURG MARGINS INVOLVED BY IN SITU COMPONENT: No LYMPH NODES POSITIVE: LYMPH NODES EXAMINED: methOD(S) Of Lymph nOde exAminaTiOn: H/E stain, Keratin stain SENTINEL NODE METASTASIS: Yes SIZE Of nODal metaStASes: Diameter of largest lymph node metastasis: 7 mm Lymph nODe metastasis(-Es) with extracApsuLAr exTensiON: No NON-NEOPLASTIC BREAST TISSUE: ALH, FCD t Stage, pathologIC: pT2 N stage, pathologic:  pN1a M STage: Not applicable ESTROGEN RECEPTORS: positive 04 PROGESTERONE RECEPTORS: positive HER2/NEU: 1+ ed
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diff --git a/output/text/ec93ca2d-d2e7-414d-b26a-4f779ab10480.txt b/output/text/ec93ca2d-d2e7-414d-b26a-4f779ab10480.txt
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index 0000000000000000000000000000000000000000..3281cd05f6dad49c4f36672cff2b4939a394d30e
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+--- Page 1 ---
+1c 0-0-3 Cascin mmn mfi1mtry 1obuli,NUs 8520/3 Site: hrast, Nos C50.9 bw 5/9/u UUID:FAB622C2-3E45-4E72-AA36-953088830993 TCGA-D8-A27I-01A-PR Redacted page 1 / 1 copy No. 4 Date: Examination: Histopathological examinatior Internal invoice No. Cost of diagnostic procedure Examination No.: Patient: XXX PESEL: XXX Age' Gender: F Material: Multiple organ resection --right breast with axillary tissues. Unit in charge:  Physician in charge: Material collected on: Material received on: Expected time of examination: up to 8 working days Clinical diagnosis: Cancer of the right breast.. Examination performed on: Macroscopic description:  Right breast$ized 19.3 x 14.2 x 5.8 cm removed along with axillary tissues sized 10 x 6 x 3 cm and a skin flap of 16.2 x 6.8 cm. Tumour sized 1.7 x 1.2 x 1.5 cm on the border of outer quadrants, located 6.3 cm from the upper boundary, 0.3 cm from the base and 1.2 cm from the skin. Microscopic description: Carcinoma lobulare invasivum (classical type) multifocale - NHG2 (3 + 2 +1; 0 mitoses/10 HPF, visual area diameter 0.55 mm). Infiltratio carcinomatosa mamillae. Parenchymal atrophy showing in the glandular tissue.. AXILLARY LYMPH NODES Metastases carcinomatosae in lymphonodis (NO Iv/x). Histopathological Diagnosis: Carcinoma lobulare invasivum multifocale mammae dextrae. Invasive multifocal lobular carcinoma of the right breast,. Metastases carcinomatosae in lymphonodis axillae (No iv/x). Cancer metastases in axillary lymph nodes.. (NHG2, pTIc, pN2a). Compliance validated by:
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diff --git a/output/text/ec941c3d-0d5d-40f8-b6c5-fce79f967348.txt b/output/text/ec941c3d-0d5d-40f8-b6c5-fce79f967348.txt
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index 0000000000000000000000000000000000000000..36fc4fdcaeedd3f072f2f7b57977ba1db095330e
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+
+--- Page 1 ---
+Surgery date: . Surgical Pathology DIAGNOSIS: D. Head of pancreas, duodenum, and common bile duct; Whipple features is identified forming a diffusely infiltrative mass (4.5 x 2.8 x 2.2 cm) in the region of the pancreatic head and possibly arising from an intraductal papillary mucinous neoplasm (2.0 x 1.5 x 1.5 cm). Tumor extends beyond the pancreas to involve peripancreatic soft tissue and the adjacent duodenal wall. The stomach and gallbladder are uninvolved by tumor. Angiolymphatic invasion is identified. Tumor involves the common bile duct and pancreatic duct. The uncinate margin is involved by tumor. The portal vein groove is negative for tumor. The pancreatic body and common hepatic duct margins are negative for tumor (see parts B and C below): however, the uncinate margin remains positive for tumor. Multiple (7 of 21) peripancreatic lymph nodes are UUID:224801AA-21C4-4070-B1FE-BAE31CC383 positive for metastatic carcinoma. TCGA-23-AAB1-01A-PR Redacted B. Pancreas, body margin, excision: Negative for tumor.. C. Common hepatic duct, margin, excision: Negative for tumor. A. Lymph node, common hepatic artery, excision: A single (1) lymph node is negative for tumor. Frozen section histologic interpretation performed by: With available surgical material [AJCCT3N1] (7th edition, 2010) This final pathology report is based on the gross/macroscopic. examination and the frozen section histologic evaluation of the specimen(s). Hematoxylin and Eosin (H&E) permanent sections are reviewed to confirm these findings. Any substantive changes ID03 identified on permanent section review will be reflected in a denseareinsnu Syc/3 revised report. 848013 Sute: Hnereashege Interpreted by: CQ6.0 Report electronically signed by. > 5/8114 Transcribed by: AMENDMENTS: (Previous Signout Date: Revision Description: Change in wording in part A of diagnosis. ....Original Diagnosis.... D. Head of pancreas, duodenum, and common bile duct; Whipple resection: Invasive grade 3 (of 4) adenocarcinoma with mucinous. features is identified forming a diffusely infiltrative mass (4.5 x 2.8 x 2.2 cm) in the region of the pancreatic head and possibly arising from an intraductal papillary mucinous neoplasm (2.0 x 1.5 x 1.5 cm). Tumor extends beyond the pancreas to involve peripancreatic soft tissue and the adjacent duodenal wall. The stomach and gallbladder are uninvolved by tumor. Angiolymphatic invasion is identified. Tumor involves the common bile duct and
+
+--- Page 2 ---
+pancreatic duct. The uncinate margin is involved by tumor. The portal vein groove is negative for tumor. Surgical margins, after re-excision (see parts B and C below), are negative for tumor. Multiple (7 of 21) peripancreatic lymph nodes are positive for metastatic carcinoma. B. Pancreas, body margin, excision: Negative for tumor. C. Common hepatic duct, margin, excision: Negative for tumor.. A. Lymph node, common hepatic artery, excision: A single (1) lymph. node is negative for tumor. Frozen section histologic interpretation performed by: With available surgical material [AJCCT3N1] (7th edition, 2010) This final pathology report is based on the gross/macroscopic examination and the frozen section histologic evaluation of the specimen(s). Hematoxylin and Eosin (H&E) permanent sections are reviewed to confirm these findings. Any substantive changes identified on permanent section review will be reflected in a revised report. ***Signing Pathologist**** GROSS DESCRIPTION: A. Received fresh labeled "common hepatic artery lymph nodes" is a 2.4 x 1.8 x 0.8 cm lymph node. Lymph node submitted. Grossed by B. Received fresh labeled "pancreatic body margin with margin up' is a 2.7 x 2.0 x 0.2 cm portion of pancreatic tissue with orientation. Margin submitted. Grossed by C. Received fresh labeled "common hepatic duct margin" is a 1.0 x 1.0 x 0.3 cm portion of tan-red fibrous tissue without orientation. Margin submitted. Grossed by D. Received fresh labeled "head of pancreas, duodenum, portion of stomach and jejunum, gallbladder" is a Whipple specimen consistent of 52.0 cm in length portion of duodenum, 7.5 x 6.5 x 5.5 cm portion of pancreas, 7.8 x 3.7 x 1.0 cm gallbladder, and a 20.0 x 7.5 x 3.0 cm portion of stomach. The pancreatic uncinate margin is inked yellow and shaved, the portal vein groove is inked black and submitted perpendicularly. There is a 4.5 x 2.8 x 2.2 cm diffusely infiltrative mass within the pancreatic head at the uncinate margin. The mass extends to peripancreatic soft tissue. A stent is present within the common bile duct. The pancreatic neck contains a 2.0 x 1.5 x 1.5 cm cyst on a side-branch duct. The gallbladder contains no choleliths. Peripancreatic lymph nodes and periduodenal lymph nodes are identified. Representative sections submitted. Grossed. by BLOCK SUMMARY:
+
+--- Page 3 ---
+Part A: Common hepatic artery lymph nodes. 1 Com hepatic artery LN (A1) Part B: Pancreatic body margin 1 Pancreatic body margin 1 2 Pancreatic body margin 2 Part C: Common hepatic duct margin. 1 Common hepatic duct margin Part D: Head of pancreas, duodenum, portion of stomach, jejunum and gallbladder 1 Uncinate margin 1 2 Uncinate margin 1 3 Uncinate margin 2 4 Uncinate margin 3 5 Uncinate margin 3 6 Portal vein groove 7 Ampulla 8 Pancreas with bile duct 9 Panc w/ pancreatic duct 10 Pancreas 1 11 Pancreas 2 12 Pancreas 3 13 Pancreas 4 14 Pancreas 5 15 Proximal stomach 16 Gallbladder 17 Pancreatic cyst 18 Peripancreatic LN 4 (D1) 19 Peripancreatic LN 5(D2) 20 Peripancreatic LN 4 (D3) 21 Peripancreatic LN 4 (D4) 22 Peripancreatic LN 3 (D5) 23 Peripancreatic LN 1 (D6) h i|d714c
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diff --git a/output/text/ecbace58-3385-4d15-a08a-1d1ce92e626c.txt b/output/text/ecbace58-3385-4d15-a08a-1d1ce92e626c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d31ed8d66b7b901a135cc2319b428ac7c1fefd74
--- /dev/null
+++ b/output/text/ecbace58-3385-4d15-a08a-1d1ce92e626c.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+Surgical Pathology Consultation Report. Specimen(s) Received 1. Nck: Right neck Level I-A 2. Nck: Right neck Level I-B 3. Nck: Right neck Level II-A 4. Nck: Right neck Level II-B 5. Nck: Right neck Level III 6. Nck: Right neck Level IV 7. Nck: Right neck Level V 8. Neck: Right hemiglossectomy, stitch marks anterior. 9. Neck: dorsal tongue margin 10. Neck: deep tongue margin 11. Neck: tongue base margin. 12. Neck: floor of mouth margin 13. Neck: right sublingual gland - 14. Lymph node: right neck level TV lymph nodes. 15. Lymph node: right neck level V lymph node. Diagnosis 1. Right neck level IA. Five lymph nodes negative for tumor (0/5) 2. Right neck level IB. Six lymph nodes negative for tumor (0/6). 3. Right neck level IIA. One of five lymph nodes positive for metastatic squamous cell carcinoma (1/5). a. The involved lymph node measures 1.5 cm.. b. No extracapsular extension. Submandibular gland with no pathologic changes.. 4. Right neck level IIB. Seven lymph nodes negative for tumor (0/7). 5. Right neck level III.
+
+--- Page 2 ---
+One of two lymph nodes positive for metastatic squamous cell carcinoma (1/2). a. The involved Iymph node measures 1.8 cm.. b. Extensive extracapsular extension present. 6. Right neck level IV. Fifteen lymph nodes negative for tumor (0/15) 7. Right neck level V. Eighteen lymph nodes negative for tumor (0/18). 8. Oral cavity; tongue; right hemiglossectomy. Squamous cell carcinoma, moderately differentiated. a. Maximum tumor dimension 3.6 cm. b. Tumor thickness 2.2 cm. c. No perineural invasion. d. No lymphovascular invasion. e. Margins negative for tumor. 9. Dorsal tongue margin. Negative for tumor. 10. Deep tongue margin. Negative for tumor. 11. Tongue base margin. Negative for tumor. 12. Floor of mouth margin. Negative for tumor. 13. Right sublingual gland.. Sublingual gland with no pathologic changes. 12. Right neck level IV. One lymph node negative for tumor (0/1). 13. Right neck level V. Seven lymph nodes negative for tumor (0/7). Synoptic Data Specimen Type: Resection:right hemiglossectomy Tumor Site: Tongue Histologic Type: Squamous cell carcinoma, conventional. Tumor Size: Greatest dimension: 3.6 cm. Tumor thickness: 2.2 cm Histologic Grade: G2: Moderately differentiated Pathologic Staging (pTNM):  pT2: Tumor of lip or oral cavity more than 2 cm but not. more than 4 cm in greatest dimension. pN2b: Metastasis in multiple ipsilateral lymph nodes, none. more than 6 cm in greatest dimension for all aerodigestive. sites except nasopharynx pMX: Distant metastasis cannot be assessed
+
+--- Page 3 ---
+Electronically verified by: Clinical History Oral CA Gross Description 1. The specimen is labeled with the patient's name and as "NCK: Right neck level I-A".It consists of a piece of fibroadipose tissue that measures 3.5 x 3.3 x 1.0 cm and contains multiple Iymph nodes that range from 0.4 to 0.7 cm. Representative sections are submitted.. 1A two lymph nodes 1B three lymph nodes 2. The specimen is labeled with the patient's name and as "NCK: Right neck level I-B". It. consists of a piece of fibroadipose tissue that measures 5.5 x 5.3 x 2.0 cm and contains multiple Iymph nodes that range from 0.3 to 2.0 cm. The submandibular gland measures 4.5 x 3.3 x 1.6 cm and is grossly unremarkable. Representative sections are submitted.. 2A submandibular gland 2B one bisected lymph node 2C-2D two lymph nodes per block 2E three lymph nodes 3.  The specimen is labeled with the patient's name and as "NCK: Right neck level II-A".  It consists of a piece of fibroadipose tissue that measures 4.5 x 3.7 x 1.5 cm and contains multiple Iymph nodes that range from 0.3 to 2.2 cm. Representative sections are submitted.. 3A-3C one bisected lymph node per block 3D two lymph nodes 4.The specimen is labeled with the patient's name and as "NCK: Right neck level II-B". It consists of a piece of fibroadipose tissue that measures 4.0 x 2.7 x 1.0 cm and contains multiple ymph nodes that range from 0.2 to 0.6 cm. Representative sections are submitted.. 4A-4B two lymph nodes per block 4C four lymph nodes 5. The specimen is labeled with the patient's name and as "NCK: Right neck level III". It consists of a piece of fibroadipose tissue that measures 6.8 x 4.0 x 1.8 cm and contains two lymph nodes that measure 2.0 and 3.2 cm in maximum dimension. The larger lymph node has a firm, tan parenchyma. Representative sections are submitted. 5A-5F larger lymph node, serially sectioned. 5G smaller lymph node, bisected 6. The specimen is labeled with the patient's name and as "NCK: Right neck level IV". It consists of a piece of fibroadipose tissue that measures 5.3 x 2.5 x 1.1 cm and contains multiple lymph nodes that range from 0.2 to 0.9 cm.  The specimen is received with a separate 4.2 x 0.9 x 0.6 cm piece of grossly unremarkable muscle. Representative sections are submitted. 6A-6B three lymph nodes per block 6C-6E four lymph nodes per block 7. The specimen is labeled with the patient's name and as "NCK: Right neck level V". It consists of a piece of fibroadipose tissue that measures 8.6 x 5.7 x 1.5 cm and contains multiple lymph nodes that range from 0.4 to 0.9 cm. Representative sections are submitted..
+
+--- Page 4 ---
+7A-7B two lymph nodes per block 7C-7G three lymph nodes per block 8. The specimen is labeled the patient's name and as "neck: Right hemiglossectomy, stitch marks anterior QS". It consists of a portion of right tongue measuring 5.5 cm AP x 3.5 cm SI x 3.0 cm ML. There is anterior suture orientation. At the inferolateral specimen aspect, there is a 1.8 cm AP x 0.5 cm ML portion of floor of mouth. There is a firm, pale tumor involving the lateral tongue. The tumor measures 3.6 cm AP x 2.2 cm SI x 1.3 cm ML. The tumor is irregularly shaped. It is Iocated at 0.4 cm from the lateral floor of mouth margin, 0.4 cm from the medial margin, 1.2 cm from the inferior margin, 0.6 cm from the anterior margin, and 1.0 cm from the posterior margin. The remaining tongue mucosa shows white plaques on the postero-dorsal surface of the tongue medially adjacent to the tumor. These plaques measure 1.3 x 0.7 cm in aggregate. The surgical margins are painted with silver nitrate; superior margins are overcoated with green dye. The tumor (three pieces) and normal tissue (two pieces) are sampled for tissue banking. Representative sections are submitted. 8A tumor, with anterior margin, perpendicular section 8B posterior margin, perpendicular section 8C tumor involving dorsal surface of tongue, perpendicular section 8D inferior margin, perpendicular section 8E tumor, with medial margin, perpendicular section 8F tumor involving the lateral surface of tongue, perpendicular section 8G tumor, with lateral floor of mouth margin, perpendicular section 8H tumor 8l mucosal plaques on postero-dorsal tongue 9. The specimen is labeled with the patient's name and as "neck: Dorsal tongue margin consists of a fragment of tissue measuring 5.5 x 0.8 cm. The specimen is submitted in toto for frozen section. 9A frozen section control 10. The specimen is labeled with the patient's name and as "neck: Deep tongue margin It consists of a fragment of tissue measuring 1.4 x 1.0 x 0.3 cm. The specimen is submitted in toto for frozen section. 10A frozen section control. 11. The specimen is labeled with the patient's name and as "neck: Tongue base margin  It consists of a fragment of tissue measuring 1.2 x 0.6 x 0.3 cm. The specimen is submitted in toto for frozen section. 11A frozen section control. 12. The specimen is labeled with the patient's name and as "neck: Floor of mouth margin It consists of two fragments of tissue measuring 0.7 x 0.4 x 0.3 and 1.0 x 0.6 x 0.4 cm. The specimen is submitted in toto for frozen section. 12A frozen section control. 13. The specimen is labeled with the patient's name and as "neck: Right sublingual gland It consists of a 2.3 x 1.5 x 0.8 cm irregular piece of unoriented soft tissue, which is painted with silver nitrate. 13A-13B serially sectioned and submitted in toto 14. The specimen labeled with the patient's name and as "lymph node: Right neck level IV Iymph nodes,  consists of a 1.3 x 0.8 x 0.7 cm lymph node. 14A bisected and submitted in toto 15. The specimen is labeled with the patient's name and as "lymph node: Right neck level V Iymph node . It consists of a piece of fibroadipose tissue that measures 4.2 x 2.3 x 1.3 cm
+
+--- Page 5 ---
+and contains multiple lymph nodes that range from 0.2 to 2.0 cm.  Representative sections are submitted. 15A one bisected lymph node 15B three lymph nodes 15C four lymph nodes Quick Section Diagnosis 9A Dorsal tongue margin:  Negative for malignancy 10A Deep tongue margin:  Negative for malignancy 11A Tongue base margin:  Negative for malignancy 12A Floor of mouth margin: Negative for malignancy (reported
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diff --git a/output/text/ecd4515f-6ac5-45cb-b1b5-747b885b114d.txt b/output/text/ecd4515f-6ac5-45cb-b1b5-747b885b114d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d56a07a0e0c012776534c74837eb286b340f8264
--- /dev/null
+++ b/output/text/ecd4515f-6ac5-45cb-b1b5-747b885b114d.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Lcdo-3 Carcinone- adrenal cortica) 8370/3 Sit: BAdrenol Glavd Certex UUID:45C2478C-53EF-4422-A9EF-33C40A3AA275 TCGA-OR-A5LO-01A-PR Redacted C 74 D Jq/b13 Procedure: Right adrenalectomy. Gross description: tumor is 760g; measuring 13.5 x 9.5 x 6cm. Diagnosis: Adrenal cortical carcinoma. Weiss score - 7. No extension into liver or kidney. No lymph node mets (+0/19).
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diff --git a/output/text/ecd92cdb-082e-44b6-8c85-f5583738531e.txt b/output/text/ecd92cdb-082e-44b6-8c85-f5583738531e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..175e21ef9a4d19dc59aa782c28798214ccf01060
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+ICS-0-3 Chci omn, mi fittnntng ouutsnd mucinorw, 8523J Procedure Date: Procedure Physician: 1/dof11 h Siti: 1yxsot Nos c50.9 Attending Physician/Copies To: UUID:B6E6765F-14BC-4D3D-9266-EF8065354070 TCGA-BH-A1FR-01A-PR Redacted PATIeNt hISTORy: * DATE OF LMP: * DATE OF LAST DELIVERY:S PRE-OP DIAGNOSIS: R BREAST CA POST-OP DIAGNOSIS: SAME OPERATIVE PROCEDURE: R SEGM MASTECTOMY CLINICAL HISTORY: MATERIAL SUEMITTED: RIGHT BREAST BIOPSY/MASS/SEGMENTAL MASTECTOMY, PROCUREMENT BY SURGICAL PROCEDURE INTRAOPERATIVS CONSULTATION: Consulr: Right breast mass: core biopsy positive for carcinoma. ER/pr's were done. An ellipse of skin with breast tissue, 8.5 by 6.5 by 5.0 cm, shows a tumor mass, 2.2 by 1.7 by 3.0 cm, located 2.0 cm from post margin.and 1.0 cm from anterior margin.. ADDENDA: Addendum DATE OF LMP: DATE OF LAST DELIVERY: PRE-OP DIAGNOSIS: R BREAST CA POST-OP DIAGNOSIS: SAME OPERATIVB PROCEDURE: R SEGM MASTECTOMY CLINICAL HISTORY: : MATERIAL SUEMITTED: RIGHT BREAST BIOPSY/MASS/SEGMENTAL MASTECTOMY, PROCUREMENT BY SURGICAL PROCEDURE INTRAOPERATIVE CONSULTATION: consult: Rignt breast mass: core biopsy positive for carcinoma. ER/pR's were done. An ellipse of skin with margin and 1.0 cm from anterior margin.. MACROSCOPIC DESCRIPTION: SUPPLEMKNTALREPORT The specimen is received fresh labeled with the patient's name and "right breast mass". It consists of an oval. yellow, soft, lobulated breast tissue, 9.s by 6.5 by 5.0 cm with surgical sutures and an ellipse of white-tan skin attached, 5.5 by 1.6 cm in greatest dimension, and is grossly unremarkable. The specimen is posterior resection margin and l.0 cm from anterior resection margin. The tumor mass if firm and focally hemorrhagic. Representative sections are submitted labeled "A1-a2* tumor and anterior resection margin: "A3- margin; rAll-A12" medial resection margin; "Al3-Al4" additional sections of the tumor; "A15" skin with underlying tissue. My signature below is attestation that I have reviewed all slides and agree with the findings as noted below. FINAL DIAGNOSIS: RIGHT SECMENTAL MASTECTOMI: - MIXED INFILTRATING DUCT AND MUCINOUS CARCINOMA. 3.0 BY 2.2 BY 1.7 CM. GOOD NUCLEAR GRADE (SEE NOTE SURGICAL MARGINS ARE NEGATIVE FOR TUMOR DUCTAL CARCINOMA IN-SITU, NON-COMEDO TYPE, PRESENT AT PERIPHERY AND NITHIN THE TUXOR SKIN, UNREMARKABLES Nore: Neuroendocrine markers will be performod and results will be reported if positive.tspecial stains including Nsr and Grimelius, are positive and support the presence of neurogndocrine features often seen in this type of breast carcinoma.**
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diff --git a/output/text/ece9e20e-ff3b-4868-8042-ba8e6056f203.txt b/output/text/ece9e20e-ff3b-4868-8042-ba8e6056f203.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2219c0a6bfbe366e65f0777b8c07ec51f6d4dd14
--- /dev/null
+++ b/output/text/ece9e20e-ff3b-4868-8042-ba8e6056f203.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+Curunoma,infiltrating ductal, nos 850of3 Site, breaot, Nus c50.9 1 /25/1 SURGICAL REPORT Name: Pathology Number: Sex: F Date Collected: DOB. Date Received: Location: M.R. Number' Doctor: Account Number: PRE-OPERATIVE DiAGNOSIS RIGhT BREAST CA pOst-OperATive DiAgnosIs RIGHT SREAST CA PROCEDURE MODIfIeD RADICAL Right mAstEctOmy, SEntinEL Lymph nODe BiOpSy. F.S.: POSSIBLE AxILlARy DissECTION TISSUES A. LYMPH NODE (S) - RIGHT SENTINEL LYMPH NODE #1**FS** 8. LYMPH NODE (S) - RIGHT SENTINEL LYMPH NODE #2**FS** C LYMPH NODE (S) - RIGHT SENTINEL LYMPH NODE #3**FS** D LYMPH NODE (S) - RIGHT SENTINEL LYMPH NODE #4**F S** E. LYMPH NODE (S) - RIGHT SENTINEL LYMPH NODE #5**FS** F LYMPH NODE (S) - RIGHT SENTINEL LYMPH NODE #6**FS** G BREAST MASTECTOMY (WMO) NODES - RiGHT BREAST AND AXILLARY CONTENTS FS DIAGNOSIS A. Lymph node #1, f.s. -- UUID: 849E9FA7-3420-427B-A310-3346CFA9F0CC DEFERRED FOR PERMANENT. TCGA-A2-A1FW-01A-PR 'Redacted B. Lymph node #2, f.s. -- DEFERRED FOR PERMANENT. c. Lymph node #3, f.s. - Deferred fOr permAnent. D. Lymph nODe #4, f.s. - POSITIVE fOR METASTATiC MALIGNAnCY (1/1).E E. Lymph node #5, f.s. -- DeFerred fOr permAnent. F. Lymph nOde #6, f.s. - DEFERRED fOR PERmAnEnt. (reported to surgeon: Dlagnosed by FINAL DIAGNOSIS A. RIGhT SENTInEL LyMPH NODE #1 -- Patlent Name Pathology Number SURGICAL REPORT Page 1 ot 5
+
+--- Page 2 ---
+Pathoiogy Number'. Patient N Lymph node positive for metastatic carcinomA. B. Right sentinel Lymph node #2 -- LymPh NoDe POsItive fOr MetaSTATic CArCInOMA. C. R|ght SENTineL LymPH NODe #3 - Lymph node positive for metastatic CarcinomA. D. Right Sentinel Lymph node #4 - Lymph noDe pOsrtive for metastatic CarcinomA. E. Right SEnTineL Lymph nODE #6 - Lymph node, negaTive fOr malignancy. F. R|ght sentinel Lymph node #6 -- Lymph node positive for metastatic cArcinomA.  right Breast and axillary contents - G. POORLy DIFfEReNTIATED jnVAsIVE DUCTAL CArCINOMA, 75 MM iN GreATESt DiMeNSiON, EXTeNDING WITHIN 25 MM. Of THe NEARESt DEEP iNKED SURGIGAL MARGIN. ALL DESiGnAteD inKeD SurGIcal mARgins ARe fREe Of TumOR. SCArFF-BLOOM-RICHARDSON BrEASt CAnCER HiStOLOgIC SCORE OF 9 (3+3+3). EXTensive AngiOlymphATic inVasiOn Is PrEsENt. REMAInINg BREAST TISSUe DISPLAyS FiBROCySTIC CHANge inCLUDINg Sclerosing Adenosis, fibrosis, Duct ectasiA, And Apocrine metaplasiA. INcidental fibroadenomA, 1o mm. in greatest Dimension. STIppLeD mIcrOcALCificATIONs AnD mOncKEBerg's MeDial CAlcificatIons Are Present in the non-NeopLAsTic tissue. thirteen reactIve RegiOnal AxillAry Lymph nODes, negative fOr MALignancy. pATHOLOGIC TNM STAGE:T3 N2a M not applicabie, STAGe IIIA, G3, INVASIVE DUCTAL CARCINOMA. PQrI Category II: 3260F. Dlegnosed by' Revlewed a: d electronicaltu xinnad nut by. COMMENT on xy Dr This case is discussed with Dr. Pathology Numberd Patlent Nam Page 2 of 5 SURGICAL REPORT
+
+--- Page 3 ---
+Patient Nam Pathology Number: Key Note Block Summary. 1---nipple, 2 through 7---tumor, 8--deep resection line, 9 .. superior/lateral/red, 10- inferior/lateral/black, 11---superior/medial/green, 12-- inferior/medial/orange, 13, 14 and 15---random, 16, 17 and 18--apparent nodes MICROSCOPIC EXAM MICROSCOPiC EXAMINATiON CONOUCTED BY PATHOLOGIST CONFIRMS FiNAL DIAGNCSIS. SYNOPTiC REPORT: Specimen. Total breast (including nipple and skin). Procedure Total mastectony (inciuding nipple and skin). Lymph Node Sampling: Sentinel lymph nodes, Axillary dissection. Specimen integrity:  Single Intact specimen (margins can be evaluated). Specimer Size: greatest dimension -- 27 cm.; additional dimensions 20 x 5.5 cm. Specimer Laterality: Right. Turnor Site.  Mid superior lateral. Tumor Size. Greatest dimension of largest focus of invasion over 0.1 cm.: 7.5 cm; Additional dimensions: 5x 3 cm. Tumor Focality: Single focus of invasive carcinoma Skin: Invasive carcinoma does not invade into the dermis or epidermis. Skeletal Muscle.  No skeletai muscle present Ductal Catcinoma In-situ: No DCIS is present. Histologic Type of Invasive Carcinorna: Invasive ductal carcinoma (no special type or not otherwise specified). Glandular. Score 3: <10% of turnor area forming glandular/tubular structures. Nuclear Pleomorphism: Score 3: Vesicular nuclel, often with prominent nucleoli, exhibiting marked  variation in size and shape, occasionally with very large and bizarre forms Mitotic Count Score 3 Overall Grade Grade 3: scores of 8 or 9. Margins: uninvolved by invasive carcinoma: Distance from closest margin: 25 mm (deep) Distance from superior margin:  35 mm. Dlstance from inferior margin: 80 rm. Djstance from posterior margin: 25 mm. D(stance from medial margin: 80 mm. Distance from lateral margin: 35 mm. Treatment Effect: In the breast -- No known presurgical therapy.  In the lymph nodes -- No known presurgical therapy Lymph-Vascular Invasion: Present. Dermal Lymph-Vascular invasion: Not identified. Lymph Nodes: Number of sentinel lymph nodes examined: 6 Tota! number of lymph nodes examined: 19 Number of lymph nodes with macrometastases: 5 15 mm. Sge of largest metastatic deposit: Extranodal Extension: Present Method of Evaluation of Sentinel Lymph Nodes: Hematoxylin and eosin, one level H&E, rnultiple levels. Immunohistochernistry. Pathologic Stage: Patlent Nam Pathology Number SURGICAL REPORT Page 4 of 5
+
+--- Page 4 ---
+Patlent Nam Pathology Number: COMMENT2  Irmmunohistochemical (IHC) staln for panKeratin (AE1/AE3) is negative for mlcrometastases in the uninvolved regional lymph nodes (specimens E and G). GROSS DESCRIPTION The specimen is received in seven separate containers labeled through G. designated A A The container is received fresh unfixed labeied *right sentinel lymph node #1 for frozen section" and consists of an ovoid nodule of apparent fat which is 0.3 x 0 3'x 0.2 cm. Sectioning reveals a 0.3 cm. tan-gray nodule. Frozen section is deferred by Dr. The entire specimen is subrnitted in one block. B. The container is received fresh unfixed labeled *right sentinel lymph node #2 tor frozen $ection" and consists of an irregular mass of apparent fat which is 0.8 x 0.6 x 0.4 cm. in greatestloverall dmension. Sectioning reveals a 0.6 cm. tan-gray nodule. Frozen section is deferred by Dr. The entire specimen is subrnitted in one block. C. The container is received fresh unfixed labeled *right sentinel lymph node #3 for frozen $ection* and consists of an ovoid mass of apparent fat which is 1 x 1 x 0.6 cm. in greatest dimention. Sectioning reveals a 0.3 cm. tan-gray area. Frozen section is deferred by Dr. D. The container Is received fresh unfixed labeled *right sentinel lymph node #4 for frozen sectlon* and consists of an ovoid mass of tan-gray firm rubbery tissue which is 1.5 x 1 x 1 cm in|greatest overall dirmension. Touch prep and frozen section are obtained by Dr. specirnen including frozen section is submitted in two blocks. .The entired E. The container is received fresh unfixed iabe!ed "right sentinel lymph node #5 for frozen section" and consists of an Irregular mass of apparent fat which is 1 x 0.4 x 0 3 cm. in greatest overal dimension. Sectioning reveals a 0.3 cm. tan-gray area. Frozen section is deferred by Dr. The entire specimen is submitted in one block. The container is received fresh unfixed labeled *right sentine! lymph node #6 for frozen section* and consists of an irregular mass of apparent fat which is 0.6 x 0.4 x 0.4 cm. Sectloning reveals a'0.3 cm. tan-gray area. Frozen section is deferred by Dr. The entire spedimen is submitted In one block. G. The container is received fresh unfixed labeled *right breast -- suture on superior/lateral aspect and consists of a 1.242 gm. apparent right breast which is 27 x 20 x 5.5 cm. in greatest overall dimenslon and has an apparent axillary tall. There is an attached suture indicating superior/iateral aspect inked with red dye, lower lateral is inked black, upper medial is inked green, lower medial is inked orange. The underlying deep is inked with yellow. There is a eccentrically placed nipple which is sightly inverted. Sectioning through the breast strona reveals a gray-white irregular-bordered tumor mass which grossly appears to be 7.5 x 5x 3 cm. In greatest overal! dimension and grossly appears to be located in the mid superior/lateral region The tumor mass is 2.5 cm. from the underlyingyellow margin, 3.5 cm. fron the superior/lateral/red margin, 8 cm. from the inferior/ateral/biack margin, 8 cm. from the superior/mediai/green margin and 7 cm. from the inferior/medial/orange margin. Sectioning trrough the attached axlllary fat reveals pink-tan nodules varying up to 1.5 cn in greatest dimension. The specimen is submitted in eighteen blocks. Patlent Nam Pathology Number:d SURGICAL REPORT Page 3 of 5
+
+--- Page 5 ---
+Patient Nams Pathology Numbei  Primary Tumor: pT3 Regionai Lymph Nodes: pN2a Distant Metasstasis: Not applicable. Ancillary Studies. ER  Performed on another specimen - Resutts: Immunoreactive tumor cells present -- Quantiation. 90% PR Performed on another specirnen -- Resutts: No immunoreactive tumor cells present Inamunoperoxidate Suties.  Performed on another specimen -- S-1500-10 Results: Negative (score 0) Microcalcfications: Present in non-neoplastic tissue. Clinical History Palpable mass. SPECIAL STAINS PERFORMED: panKeratin (blocks E, G16 through G18) Patient Nan Pathology Number: SURGICAL REPORT pge 5 of 5
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diff --git a/output/text/ecee8b38-23ae-4bba-b33c-d44f3a69a15d.txt b/output/text/ecee8b38-23ae-4bba-b33c-d44f3a69a15d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f5f7ae4aa6af000d2791d2a9d7e864c0917beb9c
--- /dev/null
+++ b/output/text/ecee8b38-23ae-4bba-b33c-d44f3a69a15d.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Formatted Path Report
+
+--- Page 2 ---
+LARGE INTESTINE TISSUE CHECKLIST Specimen type: Right Hemicolectomy Specimen size: Not specified Tumor site: Cecum Tumor size: 6.5 x 7 x 5 cm Tumor features: None specified Histologic type: Mucinous adenocarcinoma Histologic grade: Moderately differentiated Tumor extent: Subserosa Lymph nodes: Not specified Margins: Not specified Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None
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diff --git a/output/text/ecefba1e-c7b3-4290-bd6a-d0347ead578f.txt b/output/text/ecefba1e-c7b3-4290-bd6a-d0347ead578f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e1fe2fb55b26bb8aef06d92de08bd7596d992103
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Patient Name Accesslon #:. Med. Rec. #: Date of Procedure: DOB: Date of Receipt: Gender. Date of Report: Ref. Physician: Account #: Patient Address: Billing Type Additional Copy to: Ret. $ource: Clinical Diagnosis & History:. year old man with 4.7 cm right lower pole renal mass Specimens Submitted:. 1: SP: Kidney, right renal tumor., partial nephrectomy (is) DIAGNOSIS: SP: Kidney, right renal tumor, partial nephrectomy (fs): Tumor Type:  Ronal cell carcinoma - Papillary type Fuhrman Nuclear Grade NIA Tumor Size: Greatest diameter is 4.5 cm.. Local Invasion (for renal corlical typos): Not Identified Ronal Ven Invasion. Not identified Surgical Margins: Free of tumor Non-Neoplastic Kidney: Mild arlerionephrosclerosis. Adrenal Gland Not identified Lymph Nodes: Not idcntified Staging lor renal cell carcinoma/oncocyioma: pT1 Tumor <= 7.0 cm in greatest dimension limited to the kidney TATTEST THAT THE ABOVE OIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER tAATERIAL). AND THAI I HAVE REVIEWEDANDAPPROVED THIS REPORT Page 1 of 2
+
+--- Page 2 ---
+Gross Descri 1. The specimen is received fresh labeled "right ronal tunor (stitch marks tho deep surgical margin)' it consists of a 7 x 6 x 5 cm wedge shaped portion of kidney with a suture marking the deep margin. The perinephric fat is inked green. The surgical margin is inked black and the specinen is serially sectioned to reveal an encapsulaled golden yellow tumor measuring 4.5 x 3.5 x 3.5 cm. Tho lumor does not appear lo be involving tho perinophric adipose tissue and the adjacent renal paronchyma. The clearance from the resection nargin is O.4 cm. A representative section of the nearest margin is subnnitted for frozen section diagnosis. A portion of the tumor is submitted for TPS and representative sections are submitlod for oxamination. Summary of sections: FSC - frozen section control, T  tumor. SM - surgical margin, PF - perinephric fat. Summary of Sectlons: Part 1:  SP: Kidney, right renal tumor, partial nephrectomy (fs) Block Sect. Site PCs 1 FSCA 1 1 FSCB 1 PF 1 1 SM 1 6 T 8 Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the tissue sanple examinod at the time of the intraoperative consultation. 1. FROZEN SECTION DIAGNOSIS: SP: Right renal tumor B: Renal cortical neoplasm; margin at suture (B) is tree of tumo PERMANENT DIAGNOSIS: SAME Page 2 of 2 END OF REPORT
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diff --git a/output/text/ed33213e-0015-4029-a1a6-3c8f78a09000.txt b/output/text/ed33213e-0015-4029-a1a6-3c8f78a09000.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b7062cc401fa42eae3fb57e7c8e08bb3b45f97d9
--- /dev/null
+++ b/output/text/ed33213e-0015-4029-a1a6-3c8f78a09000.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+Clinical Diagnosis & History: Y/o female with left breast cancer on core biopsy Idc/pcis. Specimens Submitted: 1: sp: Sentinel node #1, level one , left axilla (fs) 2: Sp: Sentinel node #2, level one, left axilla (fs) ( UUID:D779EEF8-C83C-4CCA-A140-9BF15DCF14AE 3: SP: Sentinel node #3, level one, left axilla (fs) ( TCGA-AO-A03R-01A-PR Redacted 4 SP: Left breast 5: SP: Levels one and two left axillary contents ( 6 Sp: Level two left axillary contents. 7: sp: Level three left axillary contents. DIAGNOSIS: 1) LYMPH NODE, SENTINEL #1 LEVEL I LEFT AXILLA; BIOPSY: - METASTATIC CARCINOMA IN ONE LYMPH NODE (1/1). -THERE IS EXTRANODAL CAPSULAR EXTENSION OF CARCINOMA (<2 MN) 2) LYMPH NODES, SENTINEL #2 LEVEL I LEFT AXILLA; BIOPSY: - METASTATIC CARCINOMA IN ONE LYMPH NODE (1/1). 2.1 MM FOCUS, SEE NOTE. - THERE IS NO BXTRANODAL EXTENSION OF CARCINOMA. NOTE: THE CARCINOMA IS NO LONGER PRESENT ON DEEPER H&E STAINED SECTIONS. 3) LYMPH NODE, SENTINEL #3 LEVEL I LEFT AXILLA; BIOPSY: - ONE BENIGN LYMPH NODE (O/1). 4) BREAST, LEFT; TOTAL MASTECTOMY: - INVASIVE POORLY DIFFERENTIATED DUCTAL CARCINOMA, NOS TYPE, HISTOLOGIC GRADE III/III (SLIGHT OR NO TUBULE FORMATION), NUCLEAR GRADE III/III (MARKED VARIATION IN SIZE AND SHAPE), MEASURING 5.O CM IN LARGEST DIMENSION GROSSLY. - DUCTAL CARCINOMA IN SITU (DCIS) IS ALSO IDENTIFIED, SOLID AND CRIBRIFORM TYPES, WITH HIGH NUCLEAR GRADE AND MODERATE NECROSIS. - THE DCIS CONSTITUTES <= 25% OF THE TOTAL TUMOR MASS, AND IS PRESENT ADMIXED WITH AND AWAY FROM THE INVASIVE COMPONENT. - THE INVASIVE CARCINOMA IS LOCATED IN THE UPPER OUTER QUADRANT AND UPPER INNER QUADRANT. - THE DCIS IS LOCATED IN THE UPPER INNER QUADRANT AND LOWER INNER QUADRANT. - NO INVOLVEMENT OF THE NIPPLE BY EITHER IN SITU OR INVASIVE CARCINOMA IS IDENTIFIED.S ** Continued on next page **. Jc0-0-3 circiima, nifilfruhry duct,Ncs 85ov13 Site: hresst, Nos c5v.9. riteria h 10/21 ase is circk
+
+--- Page 2 ---
+NO CAL BITHER THE INVASIVE OR IN SITU Page COMPONENT. - CALCIFICATIONS ARE PRESENT IN THE BENIGN BREAST PARENCHYMA.S EXTENSIVE VASCULAR INVASION IS PRESENT. - POSITIVE PERINEURAL INVASION. - NO INVOLVEMENT OF THE SURGICAL MARGINS BY EITHER INVASIVE OR IN SITU CARCINOMA IS IDENTIFIED. NO SKIN INVOLVEMENT BY CARCINOMA IS IDENTIFIED. THE ATTACHED SKELETAL MUSCLE IS NEGATIVE FOR TUMOR.S - THE NON-NEOPLASTIC BREAST TISSUE SHOWS BIOPSY SITE CHANGES, FIBROCYSTIC CHANGES AND FIBROADENOMATOUS CHANGES. - THE LYMPH NODE STATUS IS AS FOLLOWS (EXPRESSED AS THE NUMBER OF POSITIVE) LYMPH NODES IN RELATION TO THE TOTAL NUMBER OF LYMPH NODES EXAMINED) : LEVEL I: 0/1. 5) LYMPH NODES, LEVELS I AND II LEFT AXILLARY CONTENTS; EXCISION: -MICROMETASTATIC CARCINOMA IN ONE OUT OF EIGHTEEN LYMPH NODES (1/18). -THERE IS NO EXTRANODAL EXTENSION OF CARCINOMA. 6) LYMPH NODE, LEVEL II LEFT AXILLARY CONTENTS; EXCISION: - UNREMARKABLE FIBROADIPOSE TISSUE. 7) LYMPH NODES, LEVEL III LEPT AXILLARY CONTENTS; BXCISION:S FOUR BENIGN LYMPH NODES (O/4). NOTE: RESULTS OF SPECIAL STAINS (ER,PR,HER2-neu) WILL BE REPORTED AS AN) ADDENDUM. SUMMARY OF LYMPH NODES: 3/26 TUMOR STAGE: T2, pN1a, MX STAGE GROUPING IIB I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OFS THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVEDS THIS REPORT. M.d., .- xeport slectronically Signed Out *** Special Studies: Result Special Stain Comment RECUT level ER-C PR-C HER2-C NEG CONT IMM RECUT NEG-HER2 Gross Description: ** Continued on next page.
+
+--- Page 3 ---
+1). The specimen is received fresh for frozen section consultation, labeled "Sentinel node number one, level 1, left axilla" and consists of a single lymph node measuring 1.3 x 0.9 x 0.7 cm. The specimen is bisected.. Entirely submitted for frozen section.. Summary of sections: FSC  -- frozen section control. 2). The specimen is received fresh for frozen section consultation, labeled. "Sentinel node number two, level 1, left axilla" and consists of two lymph nodes measuring 1.1 x 0.5 x 0.5 and 0.8 x 0.6 x 0.4 cm. The larger lymph node is inked black. Entirely submitted for frozen section. Summary of sections: Fsc -- frozen section control. 3). The specimen is received fresh for frozen section consultation, labeled "Sentinel node number three, level 1, left axilla" and consists of a single. lymph node measuring 1.0 x 0.7 x 0.6 cm. Lymph node is bisected. Entirely submitted for frozen section. Surmary of sections: Fsc --' frozen section control. 4). The specimen is received fresh labeled, "left breast, stitch marks axillary tail" and consists of a breast with attached axillary tail. The breast measures 28.0 x 25.0 x 5.0 cm with overlying skin ellipse measuring 22.0 x 10.0 cm. Situated eccentrically on the skin surface is a nipple measuring 1.2 x 1.2 cm and areola measuring 2.0 x 2.0 cm. A suture demarcates the axillary tail which measures 6.0 x 5.0 cm.  The posterior surface of. the breast is inked black, anterior superior - blue, anterior inferior - green and the specimen is serially sectioned to reveal a firm quadrant extending to the upper outer quadrant, measuring 2.0 cm from the closest deep margin. The remaining breast tissue shows a fibrofatty cut surface.  The axillary tissue is dissected to reveal a lymph node Representative sections are submitted, including the lymph node. Summary of sections: N - nipple ** Continued on next page.
+
+--- Page 4 ---
+NB  nipple base - skin S D - deep margin T tumor UIQ  upper inner quadrant LIQ  lower inner quadrant UOQ  upper outer quadrant LOQ - lower outer quadrant AA-axillary tail AALN-a bisected lymph node in axillary area 5) The specimen is received fresh, labeled "Levels 1 and 2 left axillary contents". It consists of a 3 x 2 x 1 cm portion of fibroadipose tissue.. Multiple lymph nodes identified measuring from 0.5 to 1.1 cm in greatest. dimension. All lymph nodes are submitted. Summary of sections: LN - lymph nodes 6). The specimen is received in formalin, labeled "level 2, left axillary. contents" and consists of a 1.7 x 1.3 x 0.3 cm portion of fatty tissue. Entirely submitted. Summary of sections: U-undesignated 7). The specimen is received in formalin, labeled "level 3, left axillary contents" and consists of two lymph nodes measuring 0.5 cm and 1.3 cm in maximum dimension. Entirely submitted. Summary of sections: LN- -lymph node BLN- bisected lymph node Summary of Sections: Part 1: Sp: Sentinel node #1, level one , left axilla (fs) Block Sect. Site pCs 1 fsc 1 Part 2:  SP: Sentinel node #2, level one, left axilla (fs) Block Sect. Site PCs ** Continued on next page
+
+--- Page 5 ---
+1 Page 5 of 6 fsc 1 Part 3: SP: Sentinel node #3, level one, left axilla (fs) Block Sect. Site. pCs 1 fsc 1 Part 4: SP: Left breast Block Sect. Site PCs 1 aa 1 aaln 2 d 3 1iq 2 1oq n 1 1 nb 1 1 10 : 1 t 10 2N uiq 22 uoq Part 5:  SP: Levels one and two left axillary contents Block Sect. site PCs 6 LN 18 Part 6: Sp: Level two left axillary contents Block Sect. Site PCs 1 1 Part 7:  SP: Level three left axillary contents Block Sect. Site PCs 1 bln In 1 Procedures/Addenda: Addendum Date Ordered: Status:  Signed Out Date Complete: By: Date Reported: Addendum Diagnosis ADDENDUM REPORT SITE: LEFT BREAST (PART 4) ER: 95% NUCLEAR STAINING WITH MODERATE INTENSITY PR: <5% NUCLEAR STAINING WITH MODERATE INTENSITY HER2/NEU(HERCEPTEST) : NEGATIVE (STAINING INTENSITY OF 0) ** Continued on next page **
+
+--- Page 6 ---
+CONTROLS ARE SATISFACTORY m.D. Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS: METASTATIC CARCINOM* PERMANENT DIAGNOSIS: SAME 2) FROZEN SECTION DIAGNOSIS: METASTATIC CARCINOMA PERMANENT DIAGNOSIS: SAME FROZEN SECTION DIAGNOSIS: BENIGN LYMPH NODE PERMANENT DIAGNOSIS:  SAME ** End of Report
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diff --git a/output/text/ed3534b3-dcbc-4ed5-908d-89274e854b65.txt b/output/text/ed3534b3-dcbc-4ed5-908d-89274e854b65.txt
new file mode 100644
index 0000000000000000000000000000000000000000..2c01f141bbd4902c22d53239ecad0f1d71cf43cd
--- /dev/null
+++ b/output/text/ed3534b3-dcbc-4ed5-908d-89274e854b65.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+Clinical Diagnosis & History: Left renal mass. Specimens Submitted: 1:SPKidney,left and renal vein thrombusradical nephrectomy 2:SPLymph nodes,para-aorticexcision 3:SPVein, gonadal vein,segmental excision 4:SP:Adrenal glandleftexcision DIAGNOSIS: 1.. SPKidney, left and renal vein thrombus,radical nephrectomy Tumor Type: Renal cell carcinoma-Chromophobe type highgrade with extensive necrosis (see comment) Tumor Size: Greatest diameter is 12.5 cm. Local Invasion (for renal cortical types) Extends into renal pelvis Involves renal sinus fat Involves renal hilar fat Involves medium-sized veins in region of renal hilum Renal Vein Invasion: Identified Surgical Margins: Tumor is present at less than 1 mm from the stapled renal vein resection margin; the urothelium at the ureteral margin is partially denuded Non-Neoplastic Kidney: Unremarkable Adrenal Gland: Not identified See part4 Lymph Nodes: Free of tumor Number of nodes examined:1 Staging for renal cell carcinoma/oncocytoma: pT3b Tumor grossly extends into the renal vein(s) or vena cava below the diaphragm Page1of4
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT Comment:Although there is no sarcomatoid differentiation,there is focal significant epithelial anaplasia and a high nuclear grade.The tumor also demonstrates a high proliferation index evidenced by the Ki-67 immunostain 2. SP:Lymph nodes,para-aortic,excision Lymph Nodes: Number of nodes examined:30 Number of metastatic nodes:2 The largest metastatic node is 1.5cm Perinodal (extracapsular) extension identified The metastatic focus measures 1.2 cm in greatest extent 3.SP:Vein, gonadal vein,segmental excision -Benign segment of vein SP:Adrenal glandleft, excision 4. -Benign adrenal gland Note: This case was reviewed at the GU pathology consensus conference held IATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OFTHE SLIDES (AND/OR OTHER MATERIAL).AND THAT IHAVE REVIEWEDAND APPROVED THIS REPORT. Special Studies: Result Special Stain Comment MIB-1 Ki-67 IRON MELF-M IMM RECUT NEG CONT Gross Description: 1).The specimen is received fresh labeled "left kidney and renal vein thrombus" and consists of a kidney with attached ureter, renal vessels and perinephric fat weighing 633 g in total.The kidney measures 13.9 x 7.2 x 7.8 cm.The attached ureter measures 3.5 cm in length and 0.6 cm in diameter. The attached renal vein measures 4.5 cm in length and 3.5 cm in diameter. The ureteral margin is grossly unremarkable.However immediately adjacent (less than 0.1 cm) to the renal vein staple line is a large yellowish-brown tumor thrombus measuring 3.5 cm in length and 2.5 cm in diameter.An adrenal gland is not identified. The kidney is inked black and bivalved to reveal a large necrotic mult-nodular tan-yellow tumor involving the superior and inferior poles, the renal pelvis and hilum and the renal vein measuring 12.5 x 7.5 x 6.4 cm. The tumor appears to penetrate the capsule. Sections through the remainder of the kidney reveal a pink brown parenchyma, with a poorly-defined cortico-medullary junction. The cortex measures 0.9 cm. No lymph nodes are identified in the perinephric fat.Representative sections are submitted for TPS and for permanent sections. Summary of sections UVM -- ureteral and vessel margins (renal vein margin after removal of staples) T--tumor THF-- tumor with hilar fat TSF--tumor with sinus fat TC-- tumor with capsule and perinephric fat TK--tumor with adjacent kidney Page 2of4
+
+--- Page 3 ---
+SURGICAL PATHOLOGYREPORT RP -- renal pelvis representative sections K--representative sections kidney 2).The specimen is received in formalin labeled Para-aortic lymph nodes".It consists of multiple lymph nodes ranging from 0.2 x 0.2 cm up to 2.8 x2.5 cm in greatest dimensions. Representative sections of the largest lymph nodes are submitted.The remainder of the lymph nodes are entirely submitted. Summary of sections: LN-whole lymph nodes BLN-two bisected lymph nodes,one of which is inked black LN1-lymph node number one LN2-lymph node number two LN3-lymph node three 3). The specimen is received in formalin labeled Portion of left gonadal vein".It consists of a brown tan tubular structure measuring 5.5 cm in length and 0.5 cm in diameter, with attached yellow-tan fatty tissue measuring up to 1.5 cm in thickness. Cross sections show an unremarkable luminal aspect.Representative sections are submitted. Summary of sections: U-undesignated 4).The specimen is received in formalin labeledLeft adrenalgland.It consists of a 7 x 3 x2 cm yellow-tan adrenal gland, with scant attached yellow-tan fatty tissue.The outer surface of the specimen shows a slightly ragged appearance.On cross sectioning,it shows unremarkable yellow parenchyma.Representative sections are submitted. Summary of sections: U-undesignated Summary of Sections: Part 1: SP: Kidney,left and renal vein thrombus, radical nephrectomy Block Sect.Site PCs 1 K 1 2 RP 2 4 T 4 2 TC 2 1 THF 1 1 TK 1 1 TSF 1 1 UVM 1 Part 2SP:Lymph nodes,para-aortic,excision Block Sect.Site PCs 3 BLN 3 2 LN 2 1 LN1 1 1 LN2 1 1 LN3 1 Part3:SP:Vein gonadal vein,segmental excision Block Sect.Site PCs 1 U 1 Part4:SP:Adrenal gland,left,excision Page 3 of4
+
+--- Page 4 ---
+SURGICAL PATHOLOGY REPORT Block Sect.Site PCs 2 u 2 Page 4of4 END OF REPORT
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diff --git a/output/text/ed4f2d61-a046-4d42-9caa-25ffe7757f4e.txt b/output/text/ed4f2d61-a046-4d42-9caa-25ffe7757f4e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b58682e3ea143a89f28a9eaab28b8f2a4d7cd29a
--- /dev/null
+++ b/output/text/ed4f2d61-a046-4d42-9caa-25ffe7757f4e.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:9A705521-237B-429B-B4F6-5CBF2854E252 TCGA-GS-A9TZ-01A-PR Redacted CERVICAL LYMPH NODE Three tissue fragments, the biggest measures3,7 x 2,5 x 0,9 cm and the smallest 0,5 x 0,4 x 0,3 cm. The section surface shows a homogeneous whitish color LEFT CERVICAL LYMPH NODE (EXCISION): - PRIMARY MEDIASTINAL DIFFUSE LARGE B-CELL LYMPHOMA Sections show a lymph node with the architecture effaced by atypical lymphoid proliferation, composed by sheets of large and pleomorphic cells, some with Reed-. Sternberg morphology, accompanied by a background of small cells. The neoplastic cells are positive for CD20, CD79a, CD30, CD23, CD22, BCL2, MUM1/IRF4 and BCL6 and negative for CD10, CD15 and EBER. A moderate amount of reactive T-cells, CD3 and CD5 positive is found. Stains for immunoglobulin light chains have not been contributory. The Ki67 proliferative index is 70-80%.. Normal Karyotype z0 63 .9480/3 il fmjh nali , cerical Oite. (77.0 tJ 33|14 lw 12f13 t13/3013
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diff --git a/output/text/ed7e42b1-fb69-467f-98a7-b5bf15eba676.txt b/output/text/ed7e42b1-fb69-467f-98a7-b5bf15eba676.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f804853623aaac4f008d00d2203f287fa6c01b23
--- /dev/null
+++ b/output/text/ed7e42b1-fb69-467f-98a7-b5bf15eba676.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+Department of Pathology Page 1 of 4 REPORT Tel: UUID:A904183E-A6F0-4EBA-94AB-DD95A8B858F3 TCGA-VD-A8K3-01A-PR Redacted Clinical Consultant & Location  Sex Unit No This Copy For: LcD-0-3 SPECIMEN LEFT GLOBE 877013 miyool CLINICAL DETAILS Sute: OChsridl C69.3 Choroidal melanoma. QS1117/14 MACROSCOPIC DESCRIPTION An intact left eye. Dimensions: Axial 22mm, Horizontal 22.5mm, Vertical 2lmm Cornea: Horizontal 12mm, Vertical 12mm Description: clear Optic nerve. Length 12mm, Diameter 4mm On trans-illumination, a shadow is seen, measuring 2l x 19mm, located inferomedially. Plane of section: Diagonally Intraocular description: On opening, a non-pigmented choroidal tumour (dome-shaped) is seen. Tumour size LBD 14mm, Height 13mm MICROSCOPY Histologically. the enucleated eye demonstrates a normal anterior segment with an unremarkable cornea, a deep anterior chamber and open angles. The iris leaves are unremarkable. The ciliary muscles are mildly atrophic with mild hyalinisation of the ciliary processes. The lens shows mild cataractous changes. In the posterior segment, arising at the equator, a choroidal melanoma can be.geen. This is dome-shaped with a large accompanying exudative retinal detachment. The retina Reported: Pathologist: Electronically Verifled:
+
+--- Page 2 ---
+ntat Department of Pathology. Page 2 of 4 HISTOPATHOLOGY REPORT Tel:  Surname Lab No Cllnlcal Consultant & Locatlon Forename(s)  DOB/Age Sex Unit No Request Date This Copy For: overlying the tumour is atrophic with degenerative changes. Focally, at the apex of the tumour, there is retinal invasion. The tumour is not pigmented and consists of a mixture of cells, both epithelioid and spindle cells, with a dominance of the latter. The melanoma cells are immunoreactive for MelanA, CDi17 and HSp-27 ($core 3). The number of mitoses is high, approx.18/40 high power fields. The microvasculature of the melanoma is not prominent, and closed loops are not present in the tissue planes evaluated. Occasional  *vascular lakes can be observed; in these tumour cells can be see located within the lumen. The lymphocytic infiltrate within tumour is minimal. Macrophages are scattered throughout the tumour in a mild. There is evidence of scleral invasion in the form of perivascular and intravascular infiltration of the inferomedial vortex vein. The optic nerve is tumour free, and demonstrates mild atrophic changes. The remaining examined vortex veins are free of tumour.. DIAGNOSIS Choroid melanoma of mixed cell type with invasion of the inferomedial vortex vein. COMMENT SPECIMEN 2= Eye TUMOUR PRESENTS Yes TUMOUR TYPE 1- Melanoma CELL TYPE 3= Mixed Reported: Pathologist: Electronically Verified:
+
+--- Page 3 ---
+vinled: Department of Pathology Page 3 of 4 HI$TOPATHOLOGY REPORT Tel: Surname Lab No Clinical Consultant & Locationd Forename(s)  DOB/Age Sex Unit No Request Date This Copy For: CT LOOPS 1- No closed loops. NECROSIS No PIGMENTATION NO LYMPHOCYTIC INFILTRATION No MITOTIC FREQUENCY 18 /40 HPF DIFFUSE MELANOMA No SPREAD 5= Vortex Vein CLEARANCE 3= Uncertain HSP-27 POSITIVITY 3= >70% LARGE DIAMETER 12 mm THICKNESS 4 mm COMMENTS :  Molecular genetic examination of DNA extracted from the tumour celis will be performed using multiplex-ligation dependent probe amplification (MLpA), looking at chromosomes 1. 3, 6 and 8. A supplementary report will follow as soon as these investigations' are complete.. SUPPLEMENTARY REPORT In the meantime, molecular genetic analysis of tumour DNA extracted from the fresh uveal melanoma tissue was performed using the technique termed multiplex ligation-dependent probe amplification (MLpa). These investigations were. performed in the The kit P027 from. which examines for gains or losses in 31 loci on chromosomes 1, 3, 6 and 8, was used. The DNA concentration was measured using.  and the quality assessed using multiplex-pcR prior to the MLPA reaction. The DNA concentration was high and of good quality on assessment. The MLpA reaction was run at least twice on differing occasions, resulting in similar results.. Reported: Pathologist: Electronically Verified:
+
+--- Page 4 ---
+nter Department of Pathology Page 4 of 4 HISTOPATHOLOGY REPORT Tel:  Surname Lab No Cllnlcal Consultant & Locatlon Forename(s)  DOB/Ag* Sex Unit No Request Date This Copy For: The results of the sequence analysis of the MLpA products is printed on a separate report. In summary, sequence analysis demonstrated: normal chromosome 1, normal chromosome 3, gains in chromosome 6p, loss in chromosome 6q, loss in chromosome 8p and gains in chromosome 8. These molecular data require correlation with the clinical and morphological data for metastatic risk assessment. Reported: Pathologist: Electronlcally Verified: rteria Prior Malignancy Histor
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diff --git a/output/text/ed83022b-2e54-4c07-a5a2-982bea421352.txt b/output/text/ed83022b-2e54-4c07-a5a2-982bea421352.txt
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index 0000000000000000000000000000000000000000..657ad0798db6c4b8a5340aa05b9692de5f8a2771
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+
+--- Page 1 ---
+/c Procedure Date: Circinoms mf1nting duct, Nos 85os/3 Procedure Physician: Attending Physician/Copies To: S.t Brust nus c5o.9.- M UUID:098BAFB4-94D0-4FC8-B938-D8A4108D8FC1 TCGA-BH-A1FE-01A-PR Redacted Patient history: + DATE OF LP: DATE OF LAST DRLIVERY: PRE-OP DIAGNOSIS: LEFT BREAST CA POST-OP DIAGNOSIS: SAME OPERATIVE PROCEDURE: LEET MOD RAD MAST AND AX DISS CLINICAL HISTORY:  MATERIAL SUBMITTED: A) :LEFT.-BREAST BIOPSY/MASS/SEGMENTAL MASTECTOMY, PROCUREMENT BY SURGICAL PROCEDURE B) LEFT AXILLARY LYMPH NODE(S), PROCUREMENT BY SURGICAL PROCEDURE) FINAL DIAGNOSIS: A) LEFT BREAST: - MULTIFOCAL' INFILTRATING DUCT CARCINOMA> POOR NUCLEAR AND HISTOLOGIC GRADE WITH CANCERIZATICN OF LOBULES, 3-5 BY 2.5 BY 1.S"CM, LARGEST FOCUS, OTHER FOCI MICROSCOPIC MICROCALCIFICATIONSS ANGIOLYMPHATIC INVASION IDENTIFIED - ALL MARGINS OF RESECTION NEGATIVE FOR INVASIVE TUMOR, BUT DUCTAL CARCINCMA IN SITU INVOLVES DEEP AND SUPERIOR MARGINS - NIPPLE AND SKIN UNINVOLVED BY TUMOR B) LEFT AXILLARY LYMPH NODES: ONE OF TWELVE (1/12) LYMPH NODES, POSITIVE FOR ADENOCARCINOMA (1/12)) NOTe: ER/pR immunoperoxidase assay and Her-2/Neu testing will be performed on block A3. SUPPLEMENTALREPORT (ER/PR) My signature below is attestation that I have reviewed all slides and agree with the findings as noted. below. IMMUNOPEROXIDASE IDENTIFICATION OF ESTROGEN AND PROGESTERONE RECEPTORS IS CARRIED OUT ON SLIDE A3. NO DISTINCT INTRANOCLEAR STAINING IS IDENTIFIED FOR EITHER RECEPTOR. THEREFORE, BOTH ARE INTERPRETED AS SUPPLEMENTALREPORT (HER-2/NEU) My sagnature below is attestation that I have reviewed all slides and agree with the findings as noted below. C-erbB2 (HER-2/NEU) IMMUNOSTAINING IS CARRIED OUT ON BLOCK A3 (BREAST CANCER) USING A 1:3O0 DILUTION OF DAKO'S POLYCLONAL ANTIBODY A485 (DIRECTED AGAINST THE INTRACELLULAR DCMAIN OF C-erbB2) WITHOUT ANTIGEN RETRIEVAL. NO DISTINCT COMPLETE MEMBRANE STAINING IS IDENTIFIED. THEREFORE, C-erbB2 (HER-2/NEU) IS INTERPRETED AS NEGATIVE.
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diff --git a/output/text/ed9f771c-ed75-4a23-ae37-347761595f75.txt b/output/text/ed9f771c-ed75-4a23-ae37-347761595f75.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7e7aa89d88176e18b0d711f866d01ac52e08dbac
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:1EDC857F-C9D2-4039-A86B-5110D5865B0E TCGA-KM-A7QB-01C-PR Redacted MEDICAL RECORD Surgical Pathology Report ICD o-3 Surgical Pathology Report Lyee. 831713 PatienT: MRN: ACCOUNT#: RECEIVED DATE: DOb: PrOcedure Date: 9 9J2 413 Age: SEX: M SIGN-OUT DATE: AtTending: LOCATION: REQUESTING: CONTACT NO: ROOM: COPIES TO: DiAGnosis: Kidney, right, radical nephrectomy: Renal cell carcinoma, chromophobe cell type, Fuhrman nuclear grade il; no capsular invasion seen; vascular, urteral and inked surgical margins of resectlon are free of tumor; no tumor seen in three lymph nodes (0/3): see note. NOTE: Kidney Nephrectomy Summary Table Macroscopic Specimen Type: Radical nephrectomy Laterality: Right Tumor Size: 5 x 5 x 4 cm Focality: Unifocal Macro Extent of Tumor: Confined to kidney, upper pole, laterally. Microscopic Histologic Type: Renal cell carcinoma, chromophobe cell type. Histologlc Grade:  Fuhrman nuclear grade II Extent of Invasion Primary Tumor(pT): pT1b Regional Lymph Nodes(pN):  pNO Distant Metastisis(pM): pMx ' Margins: Vascular, ureteric and surgical margins of resection are free of tumor. CLINICAL INFORMATION: Brief Clinical History: yo male with 4.5cm right renal mass,. incidental diagnosis, sporadic tumor Requestor Name Patient Identification Surgical Pathology Report File in Section 3: Tissue Examination. Page 1 of 3
+
+--- Page 2 ---
+MEDICAL RECORD Surgical Pathology Report MrN: Date of Report: Requestor Phone/Pager. Allocate Order to Protocol:. PRocEDuRe: Operative Findings: n/a Post-Operative Diagnosis: same Pre-Operative Diagnosis: right renal mass SpecimenS SubmITTed: 1. KIDney, RIGhT GROss DEscRIPTiON: Received fresh from the OR labeled with the patient's name, medical record number, and "right kidney and adrenal" is a specimen that consists of a radical nephrectomy specimen with attached adrenal gland entirely measuring, in total, 15 x 9 x 6 cm. The specimen is inked in black and bisected revealing a 5 x 5 x 4 cm tumor mass with a brown/yellow cut surface. 40% of the tumor mass is procured for along with representative sections of normal adrenal and kidney. The procurement is performed by on At  the specimen received matches the above description and weighs 240 grams. The kidney is.further serially sectioned. The tumor is towards the upper half of the kidney laterally towards the upper lateral pole. The renal capsule appears to be focally adherent over the tumor. . The adrenal is well away from the tumor and the fat around the adrenal is not apposed to the tumor . Sections are submitted as follows: : Vascular and ureteral cut margins 3 and C: Sections from areas suspicious for capsule adherence including up to inked surgical margin :: Representative section from center of tumor. -.: Section of tumor including renal pelvic fat. . Tumor with adjacent apparent uninvolved kidney. . Tumor including kidney and suprarenal fat.  Adrenal with surrounding fat. Dection from grossly normal kidney. I and K: Probable lymph node candidates from the renal hilum Gross dictated by No consultants Patient Identitication Page 2 of 3
+
+--- Page 3 ---
+MEDICAL RECORD Surgical Pathology Report Nam MRN: Uate or keport: 93 Patient Identification Page 3 of 3
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diff --git a/output/text/edc62b49-5792-4b97-aaf8-98937403bd25.txt b/output/text/edc62b49-5792-4b97-aaf8-98937403bd25.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c16a0229eb0e1b1b124d40090fb49343b9b9a119
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+IcD-o 3 8Q66/3  UUID:D45FFC62-48F3-4281-BEAF-F87E320AD6B6 C64.9 TCGA-B3-A6W5-01A-PR Redacted YtJ 7/25/13 9 7/2 s13 Final Surgical Pathology Report Procedure: Diagnosis Right kidney, nephrectomy: Clear cell renal cell carcinoma, with focal papillary features, nuclear grade 3, 2.5 cm with extension into the fat of the renal sinus, margins uninvolved. Separate papillary renal cell carcinoma, nuclear grade 2, 2.8 cm, confined to the kidney, margins uninvolved. Microscopic Description: Microscopic examination performed. The following template applies to the hilar mass: Histologic type: Clear cell carcinoma with focal papillary features. Histologic grade: Fuhrman nuclear grade 3. Primary tumor (pT): The carcinoma is 2.5 cm however extends into the fat of the renal sinus, pT3 Margins of resection:  negative Regional lymph nodes (pN): none submitted, pNX Distant metastasis (pm): cannot be evaluated by this specimen, pMX Adrenal gland: not present Vascular invasion: not identfied Non-neoplastic kidney:  unremarkable Other findings:  none The following template applies to the peripheral tumor. Histologic type: Papillary carcinoma. Histologic grade, Fuhman nuclear grade 2 Primary tumor (pT): 2.8 cm, confined to the kidney, pT1. Margins of resection:  uninvolved Regional lymph nodes (pN): none submitted, pNX. Distant metastasis (pM): pMX. Adrenal gland: not present Vascular invasion: not identified Non-neoplastic kidney: unremarkable Other findings:  none Specimen Right kidney Clinical Information Renal cancer Gross Description Received fresh and subsequently fixed in formalin labeled "right kidney" is a 406 g kidney which is predominant covered with abundant yellow lobular fat measuring 15 x 11 x 5.5 cm. (Weight and measurements including fat). The specimen shows no discrete adrenal gland. There is a 4.0 cm long ureter. The specimen is bivalved to show 2.5 x 2.0 x 2.0 cm orange irregular well-circumscribed mass located at the hilum. This is within 1.2 cm of the stapled hilum. There is an additional pale yellow irregular nodular lesion measuring 2.7 cm in greatest dimension. This is weli-circumscribed and does not appear to grossly invade through the capsule. This is located near the periphery of the
+
+--- Page 2 ---
+specimen, approximately 2.8 cm from the hilum and 2 cm from first described tumor. The remainder of the parenchyma is pink red, smooth and glistening with a discrete cortical medullary border. No other. discrete gross lesions are identified. No lymph nodes are grossly identified in the surrounding fat. Representative sections of the specimen are submitted as follows: 1 - vascular and ureteral margins, 2 5- representative tumor to radial margin and normal, 6 - possible representative sections of additional tumor to radial margin (capsule) and normal, 12  - representative section of normal between tumors
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diff --git a/output/text/ee176128-007e-48bb-900d-54eb52a15ceb.txt b/output/text/ee176128-007e-48bb-900d-54eb52a15ceb.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c53bc80e0bd0aaacfdb1309f498fc690fbb7473d
--- /dev/null
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@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UUID:D61D4CCC-2AB5-4268-AEB7-C8928E0AF964 TCGA-AC-A5XU-01A-PR Redacted  Referring Physician DOB Age: Gender: F Re# Hosp#: Provider Group : Date of Service:. Date Received Outpatient Case# Date Reported: FINAL SURGICAL PATHOLOGY REPORT Diagnosis: A. - B.) LEFT BREAST AND AXILLARY LYMPH NODE, LUMPECTOMY AND SENTINEL LYMPH NODE BIOPSY: - Invasive ductal carcinoma, Nottingham grade 3. - Tumor size: 6.8 cm in diameter.. * Ductal carcinoma in situ (Dcis), high nuclear grade, with comedo necrosis. - Dcis is extensive, involving an area larger than the area involved by. invasive carcinoma. - The inferior lumpectomy margin is involved by DCis (see comment for. additional information concerning margins). LCD6-3 - Two lymph nodes, no tumor present (0/2). 5|o/3 PATHOLOGY TUMOR STAGING SYNOPSIS: Type and grade (invasive): Invasive ductal carcinoma, Nottingham grade 3. Type and grade (in situ): Dcis, high nuclear grade. N83 Primary tumor: pT3. ts Regional ymph nodes: pNo(i-)(sn).. Distant metastasis: Not applicable.. Stage: IIB. C Lymphovascular invasion: Not identified. 50 Margin status: Margin involved by carcinoma. See comment. COMMENT: The invasive carcinoma has an irregular, elongated multilobulated NBS contiguration, with possible small satellite tumor nodules at the periphery of the tumor. In some areas, the gross appearance of the tumor was subtle, and in other. areas where invasive carcinoma was present, no grossly demonstrable tumor could 85s/ be seen. The tumor size of 6.8 cm in diameter is based on the distribution of invasive tumor in the specimen. Dcis is extensively present in association with invasive. carcinoma. The inferior margin is involved by DciS, in both the medial and lateral aspects of the specimen. In addition, DCiS is identified 0.1 cm from the anterior and superior. Case # Page 1 Printed: This Ieport continues .. (FINAL) MR No.. Acct No. 'atient Name Pathology - Page 1/5 J age 1 Doc# 1
+
+--- Page 2 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT margins. Carcinoma is identified 0.5 cm from the lateral and medial margins. Invasive. carcinoma is not identified at any margin, but is identified 0.2 cm from the anterior and superior margins.. In some areas, the invasive carcinoma has features suggestive of neuroendocrine. differentiation (nuclear molding, relatively scant cytoplasm, inconspicuous nucleoli), and this impression is supported by positive staining for synaptophysin in tumor. cells. pw TSs,O?o Mewroinelorrin emcnnor Tunr1s 1O0% duc$l Bce Intradepartmental consultation has reviewed representative slides, and concurs with the above diagnosis. Invasive Breast Cancer Tumor Staging Information AJCC Cancer Staging Handbook, 7th Ed., and CAP Protocol (revised June 2012) Previous pathology specimens: : Case #. Page 2 This report contnues...(FINAL). Printed: MR No. + Acct No.: Patient Name : Pathology - Page 2/5 Jor : Page 2 Doc# 1
+
+--- Page 3 ---
+Patient: Case # SPECIMENIDENTIFICATION Procedure/specimen type: Lumpectomy. Laterality: Left. Lymph node sampling: Sentinel lymph node biopsy.. INVASIVE CARCINOMA TUMOR CHARACTERISTICS Histologic type Invasive ductal carcinoma (with neuroendocrine differentiation). Tumor site: 1:00 aspect. Tumor size: 6.8 cm in diameter. Tumor focality Single tumor focus (multilobulated) irregularly shaped tumor with possible satellite nodules at Ihe periphery of the tumor) Histologic grade (Nottingham Score): 30f3 Tubule formation: 3 of 3. Nuclear pleomorphism: 3 of 3. Mitotic rate: 3 of 3. Lymphovascular invasion: Not identified. Macroscopic and microscopic extent of tumor Skin and chest wall invasion cannot be assessed. DUCTAL CARCINOMA IN SITU (DCIS) Present.exiensive,nuclear grade 3 MARGINS Invasive carcinoma: Invasive carcinoma is 0.2 cmn from anterior and superior margins, 0.5 cm from medial margin, and is at least 0.5 cm from all other margins. Ductal carcinoma in situ: Present at inferior margin, 0.1 cm from anterior and superior margins, 0.5 cm from lateral margin. at least 0.5 cm from medial margin. LYMPH NODES Two. Total lymph nodes examined. Zero. Number of lymph nodes involved PATHOLOGIC STAGING Primary Tumor (pT): pT3. Regional lymph nodes (pN). pNO(i)sn) Distant metastasis (pM) Not applicable. AJCC Stage: 118 ANCILLARY STUDIES: Estrogen receptor:. 95% posilive cells Case # Page 3 This report continues... (FINAL). Printed: MR Ni Patient Name Pathology - Page 3/5 JOD rage 3 Doc#1
+
+--- Page 4 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT Progesterone receptor: 60% positive cells. HER2: INC 0. Ki-67: 25% positive cells. Signed by Source of Specimen: A. Sentinel lymph node;Left axillary? B. Breast lumpectomy;Left Clinical History/Operative Dx: Malignant neoplasm of breast (female) unspecified sile. Gross Description: A.Part A is sentinel node #1, left axillary. Received in formalin is a 2.4 x 1.8 x 1.8 cm portion of. fatty soft tissue. Examination reveals a lymph node, 1.6 x 1.0 x 0.7 cm. The lymph node is serially sectioned and entirely submitted for microscopic evaluation in A1 with a sentinel node protoco! performed. A second lymph node is 0.4 x 0.3 x 0.2 cm. This lymph node is bisected and submitted in A2.. Routine histology and sentinel node protocol is performed on blocks A1 and A2.. B. Part B is left breast mass. Initially received in the fresh state for possible Oncogenotyping studies is a. 178 gram yellow-tan portion of fibrofatty sofl tissue. 9.3 cm superior-inferior, 9.3 cm medial-lateral, and 4 8 cm posterior-anterior. An overlying ellipse of wrinkled.tan skin is 7.5 x 1.1 cm. Two sets of sutures are present: a double long suture marks lateral and a double short suture marks superior. The surgical margins. are now differentially inked as tollows: SUPERIOR:BLUE MEDIAL:RED ANTERIOR: YELLOW Case# Page4 Printed: This report continues... (FINAL) MR No Acct No. - Patient Name  Pathology - Page 4/5 JOD - Page4 Doc# 1
+
+--- Page 5 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT INFERIOR: GREEN LATERAL:ORANGE POSTERIOR:BLACK The specimen is sliced trom medial to lateral in seven slices. with slice #1 most medial, slice #7 most Iateral. There is an irregularly shaped elongated mass measuring 6.8 x 3.5 x 2.4 cm (present in slices #1-6). The tumor is 0.7 cm from the medial, 1.8 from the lateral, 0.6 cm from the anterior, 1.9 cm from the posterior, 0.4 cm from the superior (slab 3) and 1.8 cm from the inferior surgical margins. Representative tissue submitted for Oncogenotyping studies. A second partially calcified, light gray fibrous nodule is 1.1 x 0.7 x 0.6 cm, located along the inferior aspect in slice #2. Cassette summary: B1-B3) slab 1, medial including tumor relationship, B4-B7) slab 2, including superior, inferior, medial-posterior, anterior and tumor relationship, B8) fibrous-calcified nodule, along inferior margin, slab 2, over-night decal performed, B9-B14) slab 3, inferior, superior, anterior, posterior surgical margins including tumor relationship. B15-B20) slab 4, anterior,superior, inferior,posterior surgical margins and tumor relationship, 821-B25) slab 5. interior, posterior, anterior, superior surgical margins and tunor relationship, and representation of bulk of tumor, B26-B30) slab 6, inferior, anterior, posterior, and superior surgical margins, area suspicious for tumor. B31-B35) slab 7, lateral., edge of interior margin represented. Microscopic Description: A. Immunohistochemical stain: CK-OsCAR, showing no evidence ot inetastatic carcinoma. Appropriate positive and negative controls reviewed B. tmmunohistochemical stain: synaptophysin, showing positive staining in tumor cells, Appropriate positive and negative controls reviewed. 4/24/13 Case # Page 5 Printed: END OF REPORT (FINAL) MR No. ~ Acct Nc tent Name - Pathology - Page 5/5 age 5 Doc# 1
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diff --git a/output/text/ee510540-850a-42c1-9b25-7fd768dac541.txt b/output/text/ee510540-850a-42c1-9b25-7fd768dac541.txt
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index 0000000000000000000000000000000000000000..e8720c7600e5e5988da010cd306261967f644c7d
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+
+--- Page 1 ---
+/cD-0-3 Csciioma, mhidf^ntmy ouctdl, Nos 85ot/3 Pwth S,h. Bsn#,uDQ C5O,4 1/21/1 CQeF Site: Busot N0s c50.9 Diagnosis: Right/sided partial breast resection material with a poorly differentiated invasive ductal breast. carcinoma measuring a maximum of 3.4 cm with a minimum dorsal margin of 0.1 cm.. evidence of carcinomatous lymphangitis and two axillary Iymph node metastases (of 20 lymph nodes studied). The follow-up resection samples in nos 2 and 3 were both carcinoma- free. Tumor classification: M-8500/3, G 3, pT 3, pN 1a (2/20), M X, R 0, L 1, V 0. UID:5D93 40-4809-AE7C-54814CED0851 TCGA-A8-A07L-01A-PR Redacted
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diff --git a/output/text/ee60d2b8-5ed3-4d57-b278-918c6fff543a.txt b/output/text/ee60d2b8-5ed3-4d57-b278-918c6fff543a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c2c0a662097cb61eb831f9af2214cbe139dbdcc4
--- /dev/null
+++ b/output/text/ee60d2b8-5ed3-4d57-b278-918c6fff543a.txt
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+
+--- Page 1 ---
+Specimen Number: Date of Birth: Age: Ordering Physlclan: Phone #: Gender: Patient locatlon: Collection date: Received date: zeDo-3 SPECIMEN 8/20/3 A. URETER - 1. Right distal ureter margin (FS) B. URETER - 2. Left distal ureter margin (FS) Lotol wolly blodoles C. LYMPH NODE(S) - 3. Right pelvic lymph nodes D. BLADDER - 4. Bladder prostate (fresh for Genome Project) 8 Cb72 E. LYMPH NODE(S) - 5. Left pelvic lymph nodes DOL RIadder waQ No S C67.9 CLINICAL INFORMATION Transitional cell carcinoma bladder COPY TO: GROSS DESCRIPTION The specimens are recelved in five containers, each labeled with the patient's name. Part A is received fresh for frozen section diagnosis labeled "distal ureter margin right" and consists of a 0.7 x 0.4 x0 .2 cm portion of tan tissue, which is submitted in toto for frozen section diagnosis as FSA1. The frozen section residue is submitted as (A1). Frozen section diagnosis: FSA1 -- Right distal ureter margin -- "No tumor seen.' ExamIned by Part B is received fresh for frozen section diagnosis labeled left distal ureter margin" and consists of a 1.4 x 0.2 x 0.1 cm strip of tan soft tissue, which is submitted in toto for frozen section diagnosis as FSB1. The frozen section residue is submitted as (B1). UUID:65FF34F8-65D4-4DC8-80D8-FED4D8244F4B Frozen section diagnosis: TCGA-R3-A69X-01A-PR Redacted FSB1 -- Left distal ureter margin -- "No tumor seen. Examined by Page 1 of 4 Patient Name
+
+--- Page 2 ---
+Part C is received in formalin labeled "right pelvic lymph nodes" and consists of a 5 cm portion of adipose tissue, which contains eight 0.2 cm -- 1.7 cm lymph nodes. The lymph nodes are submitted In their entirety as (C1)-(C5). SLIDE KEY C1 -- four possible lymph nodes C2-C5 -- one bisected lymph node per cassette Part D is received fresh labeled "bladder/prostate" and consists of a 6 x 5 x 4 cm urinary bladder, in. continuity with 2 x 0.5 cm segments of bilateral ureters, symmetrical 4 x 3 x 3 cm prostate gland with bilateral 2 x 1 x 0.5 cm seminal vesicles and a moderate amount of soft perivesicular adipose tissue. There are multiple staples over the mid anterior aspect of the prostate and bladder. The right side of the specimen is inked blue, the left side is black and the mid anterior aspect of the prostate Is inked orange. The bladder is opened to dlsclose a 3 x 1.9 cm ulcer over the right posterior wall, mid posterior walls, extending to left lateral wall and overlying the left ureteral orifice. Sections through the ulcer show a 2.9 x 2.5 x 1.2 cm firm gray-white mass within the left posterior wall and left lateral wall. The mass extends through the bladder wall, 1.6 cm from the left lateral soft tissue margin. The mass does not grossly. Involve the prostate gland and is located approximately 4.5 cm from the urethral margin. The mass does not grossly involve the right side of the bladder. The remaining bladdar mucosa is tan and trabeculated without additional gross lesions. Sections through the prostate gland show a well-defined 0.4 cm white nodule within the right side, near the apex. The remainder of the prostate gland consists of dense tan tissue with focal fine honeycombing. No gross lesions can be identified within the seminal vesicles. No Iymph nodes can be identified within the specimen. Fresh tumor is taken for TCGA. Representative sectlons are submitted as (D1)-(D24). SLIDE KEY D1 -- right ureter D2 - left ureter D3 -- right prostate apex margin D4 -- left prostate apex margin D5 -- trigone/prostatic urethra D6 -- trigone/right ureteral orifice D7 - trigone/left ureteral orifice D8 -- left lateral soft tissue margin D9-D11 -- Jeft lateral bladder lesion D12 -- right posterior bladder D13 -- right lateral bladder D14 -- anterior bladder. D15 -- dome of bladder D16-D19 -- right side of prostate, apex to base D20-D23 -- left side of prostate, apex to base D24 -- seminal vesicles Part E is received in formalin labeled "left pelvic lymph nodes" and consists of a 3 cm aggregate of adipose tissue, which contains a 2.5 cm partially fatty lymph node. The lymph node is submitted in its entirety as (E1). Page 2 of 4
+
+--- Page 3 ---
+MICROSCOPIC DESCRIPTiON Sections examined on multiple H&E-stained slides.. Surglcal Pathology Cancer Case Summary, Urinary Bladder -- Radical Cystoprostatectomy: SPECIMEN: Bladder and prostate. PROCEDURE: Radical cystoprostatectomy. TUMOR SrTE: Invasive tumor is noted along the left posterior and left lateral bladder wall. TUMOR SiZE: 2.9 x 2.5 x 1.2 cm. HISTOLOGIC TYPE: Urothelial cell carcinoma.. ASSOCIATED EPITHELiAL LESIONS: Focal carcinoma In situ also present. HISTOLOGIC GRADE: High grade. MICROSCOPIC TUMOR EXTENSION: Through detrusor muscle into perivesical fat. MARGINS: Not involved. Tumor does extend to within 0.7 cm of the left lateral perivesical fat margin. LYMPHOVASCULAR SPACE INVASION: Present, extensive. PATHOLOGIC STAGING: Primary Tumor: pT3, tumor invades perivesical tissue. Grossly, the tumor did appear to extend through the detrusor muscle. However, a true extravesicular mass was not identified. As such, I would favor that this is best categorized as a pT3a rather than pT3b. Regional Lymph Nodes: pN0, no lymph node metastases. Number of lymph nodes examined: 7. Surgical Pathology Cancer Case Summary, Prostate Gland -- Radlcal Prostatectomy: PROCEDURE: Radical cystoprostatectomy. PROSTATE SIZE: 4 x 3 x 3 cm. Cannot give accurate weight as the prostate was part of a larger cystoprostatectomy procedure. LYMPH NODE SAMPLING: Pelvic lymph nodes present. HISTOLOGIC TYPE: Adenocarcinoma (acinar, not otherwise specified) HISTOLOGIC GRADE: Primary Pattern: Grade 3. Secondary Pattern: Grade 4.. Total Gleason Score: 7 (moderately poorly differentiated). TUMOR QUANTITATION: Tumor comprises approximately 2% of the submitted prostate tissue. EXTRAPROSTATIC EXTENSION: Not identified. SEMINAL VESICLE INVASION: Not identified. MARGINS: Not involved. TREATMENT EFFECT: Not identified. LYMPHOVASCULAR SPACE INVASION: Not identified. PERINEURAL INVASION: Present. PATHOLOGIC STAGING: Primary Tumor: pT2c, bilateral disease. Regional Lymph Nodes: pN0, no regional lymph node metastasis.. Number of lymph nodes examined: 7, none involved (0/7).. Page 3 of 4
+
+--- Page 4 ---
+ADDITIONAL PATHOLOGIC FINDINGS: High-grade prostatic intraepithelia! neoplasia. FINAL DIAGNOSIS RIGHT DISTAL URETER MARGIN Negative for mallgnancy.. LEFT DISTAL URETER MARGIN Negative for malignancy.. RIGhT PELVIC LYMPH NODES, EXCISION  Six lymph nodes, all negative for metastatic carcinoma (0/6) BLADDER AND PROSTATE, RADICAL CYSTOPROSTATECTOMY BLADDER  High-grade urothelial cell carcinoma with invasion through detrusor muscle into perivesical fat. See microscopic/cancer case summary. PROSTATE Prostatic adenocarcinoma, Gleason pattern 3+4=7 (moderately poorly differentiated). See microscopic/cancer case summary. LEFT PELVIC LYMPH NODE, EXCISION  Single lymph node, negative for metastatic carcinoma (0/1). CPT CODES: 88331x2, 88305x3, 88307x1, 88309x1 (Electronically signed by) (Final) Verified: W 4|43) Page 4 of 4
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diff --git a/output/text/eec7909c-04b8-4933-8477-fd3c9498ad6f.txt b/output/text/eec7909c-04b8-4933-8477-fd3c9498ad6f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6fa1780c600599291684d6c0dc4620a2d2707cfe
--- /dev/null
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+
+--- Page 1 ---
+7D6-3 Cacmomo, rnaQ ceOl Chromephohe83)7/3 SURGICAL PATHOLOGY Site D%idnyHOS Case Number : 0649 8/9]L3 Diagnosis: Kidney, left, partial nephrectomy Histologic tumor type/subtype: renal cell carcinoma, chromophobe. type Sarcomatoid features: not identified Histologic grade (if applicable): 3 (of 4, Fuhrman classification) Tumor size (greatest dimension): 5.1 cm Tumor focality: unifocal Extent of invasion: Extra-capsular invasion into perinephric adipose tissue: not identified Venous (large vessel): not identified Lymphatic (small vessel): not identified Surgical margins: Renal parenchymal margin: negative but close (1 mm to blue in A6) Renal capsular margin: not involved Perinephric adipose tissue margin: not involved. Adrenal gland: not received Lymph nodes: none received Reda ted Other significant findings: none AJCC Staging: pT1b pNx pMx This staging information is based on information available at the time of this report, and is subject to change pending clinical review and additional information.. Clinical History: -year-old female with a left renal mass.
+
+--- Page 2 ---
+Gross Description:. Received is one appropriately labeled container, additionally. labeled "left renal mass partial nephrectomy." It holds a 35 gram, 5.2 x 4.7 x 3.4 cm partial nephrectomy with a small amount of attached perinephric fat overlying the capsule. The parenchyma is marked blue and the perinephric fat is inked black. The specimen is sectioned to reveal a 5.1 x 3.4 x 2.2 cm solid, variegated, orange/yellow/tan cortical nodule which focally abuts the blue inked parenchymal margin and expands, but does not grossly breech the capsule. The adjacent renal parenchyma is compressed and grossly unremarkable. The. perinephric fat is grossly unremarkable.. Block summary: Al - tumor and blue inked parenchymal margin. A2 - tumor and perinephric fat. A3 - tumor expanding capsule. A4-A6 - representative central sections of tumor Tumor has been given to Tissue Procurement.. Light Microscopy:. Light microscopic examination is performed by Dr.. Sections show a unifocal mass with solid sheets of eosinophilic and clear cells with focal punched-out perinuclear clearing. The differential includes clear cell carcinoma and eosinophilic. variant of chromophobe carcinoma. To clarify lineage, immunostains were performed, and show reactivity for ck7, with. no reactivity for c-Kit or Rcc. This immunophenotype supports a. diagnosis of chromophobe carcinoma, and makes renal cell carcinoma unlikely. Dr. concurs.
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diff --git a/output/text/eecc00f3-9451-4cb3-afc3-7577a8adc6ff.txt b/output/text/eecc00f3-9451-4cb3-afc3-7577a8adc6ff.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d5aa7859382db4fd23526c29d45e3f0e569597d4
--- /dev/null
+++ b/output/text/eecc00f3-9451-4cb3-afc3-7577a8adc6ff.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Final Diagnosis Left kidney, partial nephrectomy:. Papillary renal cell carcinoma, Fuhrman nuclear grade 3. Tumor measures 3.5 cm in maximum dimension.. Tumor is confined to kidney, surgical margins of resection are free. No lymphovascular invasion is identified.. Comment: This case corresponds to a pathological AJCC stage of T1a,NX Clinical Information Left renal mass.. Operating Room Consultation. Left partial nephrectomy. No ORC. Gross Description "A, Left partial nephrectomy." Received is a.  4.2 x 3.7 x 3.1 cm portion of kidney with attached perinephric fat. The resection margin will be inked black. The specimen has been previously sectioned to reveal a 3.5 x 2.7 cm pale tan, focally cystic mass. The mass grossly appears to abut the adjacent renal capsule. The Gerota's fascia overlying the mass will be inked orange. The mass grossly appears to come to within 0.6 cm of the resection marain. "A1-A2," mass with resection  margin; "A3-A4," mass with adjacent perinephric fat and Gerota's fascia.
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diff --git a/output/text/eed61c67-eb48-4d78-ae56-2376e66ebaf2.txt b/output/text/eed61c67-eb48-4d78-ae56-2376e66ebaf2.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e59b432866d554ee52b3e2323ecfd2f7f15c4397
--- /dev/null
+++ b/output/text/eed61c67-eb48-4d78-ae56-2376e66ebaf2.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+Surgical Pathology Report * Revised * Name: Case #: DOB: Collected: Gender: Received: MRN: Reported: Location: Copy To: Physician: Pathologic Interpretation: A. Left breast mastectomy (fresh) 1 - stitch superior / 2 - stitch lateral:. Infiltrating ductal adenocarcinoma, high nuclear grade (5.0 cm in greatest dimension). Margins free of tumor Florid adenosis and stroma fibrosis. ER, PR and HER 2-new were ordered, addendum to follow.. Jcs-0 -3 B. Sentinel node #1- fs Carcinonn, rmedullery, nos 851g/3 Lymph node, no malignancy seen.. Sit: braot, Nts 3/12/ Keratin ordered, addendum to follow.. C50.9 h C. Sentinel node #2- fs Lymph node, no malignancy seen.. UUID:70C8D54A-9698-4275-BD96-A6EF2E264748 Keratin ordered, addendum to follow. TCGA-EW-A1P4-01A-PR Redacted D. Sentinel node #3- fs Lymph node, no malignancy seen. Keratin ordered, addendum to follow. E. Left breast implant capsule short stich superior, long stich lateral:. Implant capsule.d F. Lett breast implant: See gross description. Surgical Pathology Cancer Summary Macroscopic: Mastectomye Lymph node: Sentinel lymph node Specimen Size: Greatest dimension:19.0 cm/additional dimensions 18.5 x 2.3 cm. Laterality: Left. Tumor Site: Not specified Microscopic: Size of invasive component: Greatest dimension 5.0 cm/ additional dimensions: 2.0x3.Ocm Histologic Type: Invasive ductal carcinoma Tubule Formation: Minimal less than 10% (score-3). .ix.c Nuclear Pleomorphism: marked variation in size, nucleoli, chromatin clumping, etc (score=3) For a 40 x objective with a field area of 0.152 mm2: score 1 Total Nottingham Score: Grade II: 6-7 points. Lymph nodes (pN): Pending keratins Primary tumor: (pT3c) tumor more than 5.0 cm in greatest dimension. Distant Metastasis (pMX): Cannot be assessed Margins uninvolved by invasive carcinoma/distance from closest margin: 0.1 cm deep Venous Lymphatic: Absent. Microcalcifications: Not identified ***Electronically Signed Out By*** NOTE: Some immunohistochemice) antibodies at agayte specific reegen's (ASRs) validated by our laborstory (Hor ?. Parvo, H. pyion, HBcore). These ASRs are cinicaty useld indicators that do With formalin or molecular Axed. peramn ombedded tissue. Detoction is by LSAB. The resuits ere road by = pathoiogist ss positive or negative. , MD
+
+--- Page 2 ---
+SURGICAL PATHOL Report As the attending pathologist, I attest that l (i) Examine the relevan! praparation(s) for the spocirnon(s); and () Renderad the diagnosis(es). Amendments Amended: MD  Reason: Diagnosis editing/clarification Previous Signout Date: Procedures/Addenda Date Ordered: Status: Signed Out Addendum Date Complete: Date Reported: Addendum Diagnosis A. Left breast mastectomy (fresh) 1 - stitch supenor / 2 - stitch lateral: Tumor is negative for ER, PR and HER 2. HLA-DR ordered addendum B. Sentinel node #1- fs c Keratin is negative for tumor. C. Sentinel node #2- fs : Keratin is negative for tumor. D. Sentinel node #3- fs : Keratin is negative for tumor. MD Date Ordered: Status: Signed Out Addendum Date Complete: Date Reported: Addendum Diagnosis A. Tumor is positive for HLA-DR, which along with morphology supports a medullary subtype. , MD Intraoperative Consultation AFS. Left breast mastectomy (fresh) 1 - stitch superior I 2 - stitch lateral: BFS. Sentinel node #1- fs One lymph node, no tumor seen. CFS. Sentinel node #2- fs One tymph node, no tumor seen. DFS. Sentinel node #3- fs  One lymph node, no tumor seen. Page 2 of 3
+
+--- Page 3 ---
+SURGICAL PATHOL Report MD Clinical History: Patient is a with breast cancer.. Pre Oporative Diagnosis:  Breast cancer Specimen(s) Received: A: Left breast mastectomy (fresh) 1 - stitch superior I 2 - stitch latera! B: Sentinel node #1- fs 1 C: Sentinel node #2- fs D: sentinel node #3- fs c E: Left breast implant capsule shrot stich sueperior, long stich lateral F: Left breast implant Gross Description: A. Received fresh and tabeled "left breast mastectomy (fresh) 1-stitch superior / 2 - stitch lateral" consists skin[mastectomy weighs 380.0 grams and measure 19.0 x 18.5 x 2.3 cm. The areola complex measure 3.7 x 2.4 cm and it is[grossly unremarkable with no areas indurations. Sectioning of the specimen a tumor located in the upper outer quadrant measure 5.0 cm from superior to inferior, 2.0 cm from superficial to deep and 3.0 cm from medial to lateral. Tumor logated 0.1 cm away from the deep margin. The tumor is well encapsulated and has iobulated appearance. The second ill-define area of fibrosis is present at the upper inner upper quadrant, 2.5 cm x 1.0 x 1.0 cm. The overall stoma to fat to ratiojis approximately 25.0% stroma. No other suspicious areas identified after serial sectioning. Sections submitted as follows. Sections of nippie 1 2-4 Sections of the lesion in relation to the deep margin 5 Sections of the lesion in relation to adjection fibrotic stroma. 6&7 Sections from the upper inner quadrant stroma with sixteen ill-defined areas described 8&9 Sections from the lower inner quadrant stroma 10&11  Sections from the upper outer quadrant stroma 12&13  Sections from the lower outer quadrant stroma B. Received fresh and labeled "sentinel node #1- fs consists of a lymph node, 2.0 x 1.5 x 1.0 cm. Specmen bisected and submitted in toto in one cassette for frozen. c. Received fresh and labeled *sentinel node #2- fs : consists of a lymph node, 2.0 x 1.5 x 1.0 cm. Specimen bisected and submitted in toto in one cassette for frozen.. D. Received fresh and labeled *sentinel node #3- fs - consists of a lymph node, 1.5 x 1.2 x 1.0 cm. Specimen. bisected and submitted in toto in one cassette for frozen.. E. Received in formalin and labeled *left breast implant capsule short stich sueperior, long stich laterar" consists of two pieces irregular shaped membrane tissue, 7.0 x 6.0 x 3.0 cm in aggregate. Representative sections submitted in two cassettes. F.  Received in formalin and labeled "left breast implant" consists of a breast prosthesis which weighs 1.97.0 grams and  measure 10.0 cm in diameter by 3.5 cm. The following inscription is attachec only. Gros description ICD-9(s): 174.8 Page 3 of 3
+
+--- Page 4 ---
+Addendum Accession #: Patient Name: Taken: Med. Rec. #: Recelved: DOB: Reported: Gender: Client: Billing #: Physician(s): Location: Service: Copy To: Specimen(s) Received: A: Left breast mastectomy (fresh) 1 - stitch superior / 2 - stitch lateral. B: Sentinel node #1- fs C: Sentinel node #2- fs  D: sentinel node #3- fs . E: Left breast implant capsule shrot stich sueperior, long stich lateral F: Left breast implant Date Ordered: 1 Status: Signed Out Addendum Diagnosis A. Left breast mastectomy (fresh) 1 - stitch superior / 2 - stitch lateral: Tumor is negative for ER, PR and HER 2.. HLA-DR ordered addendum B. Sentinel node #1- fs Keratin is negative for tumor. C. Sentinel node #2- fs t Keratin is negative for tumor. D. Sentinel node #3- fs  Keratin is negative for tumor. ***Electronically Signed Out*** , MD
+
+--- Page 5 ---
+Addendum Patient Name: Accession #: Med. Rec. #: Taken: DOB: Recelved: Gender: Reported: Billing #: Client: Physician(s): Location: Copy To: Service: Specimen(s) Received: A: Left breast mastectomv (fresh) 1 - stitch superior / 2 - stitch lateral B: Sentinel node #1- fs C: Sentinel node #2~ fs D: sentinel node #3- fs . E: Lett breast implant capsule shrot stich sueperior, long stich lateral F: Left breast implant Date Ordered: Status: Signed Out Addendum Diagnosis A. Tumor is positive for HLA-DR, which along with morphology supports a medullary subtype. ***Eiectronicallv Signed Out** ,, MD Page 1 of 1
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diff --git a/output/text/ef10c7e5-f12f-404a-b2a6-ec5504936b4c.txt b/output/text/ef10c7e5-f12f-404a-b2a6-ec5504936b4c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a03e29723bf8383f364038a85d1a8e5418def9a9
--- /dev/null
+++ b/output/text/ef10c7e5-f12f-404a-b2a6-ec5504936b4c.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+ICD-O-3 arcenona, peapillary reralcesl UUID: 3B9C37B5-FDEF-40B8-911E-610B3EA99D7B 8Q6013 CgA-5p-A9JV-01A-PR Redacted h3 6/13/14 1 and 2. Papillary Renal Cell Carcinoma TNM Classification: Malignant tumor (version 2002), pT1a, GII Laterative hw 5|b/1y
\ No newline at end of file
diff --git a/output/text/ef29be5e-04f0-436b-8c2a-502094acf976.txt b/output/text/ef29be5e-04f0-436b-8c2a-502094acf976.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8a08e678655b46f63e34e427dbf843a5f5ce2701
--- /dev/null
+++ b/output/text/ef29be5e-04f0-436b-8c2a-502094acf976.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+: :: Page 1 of 3 UUID:CB2ES6BC-16AC-4BFE-AB6C-2FC7E48943B8 TCGA-B6-A40B-01A-PR Redacted Patlent: AP Surgical Pathology: Fina! Surg Path 1 cD ~O-3 carcinoma, inF1+rati nqIobwIgr,NDS CLINICAL HISTORY:S 85x/3 Left ca breast. 5i+c:b<ost,N0s cS,9 7-z-sz rp GROSS EXAMINATION: A. "sentinel node # 1 hot and blue", received fresh and placed in formalin. 1.8 x 1.4 x 0.8 cm lymph node candidate with attached adipose tissue is. sectioned and submitted in toto in Al. A cytokeratin stain is prospectively requested. B. "sentinel node # 2 hot and blue", received fresh and placed in formalin. 1.4 x 1.2 x 0.7 cm lymph node candidate with attached adipose tissue is. A sectioned and submitted in B1. A cytokeratin stain is prospectively requested. C. "sentinel node # 3 hot not blue", received fresh and placed in formalin.. 1.3 x 0.8 x 0.5 cm lymph node candidate with attached adipose tissue is. A sectioned and submitted in c1. A cytokeratin stain is prospectively requested. D. "Left breast partial mastectomy skin anterior, short superior, long lateral", received fresh and placed in formalin. A partial mastectomy specimen with the following measurements: medial-lateral 7.5 cm, anterior posterior 6 cm, superior-inferior 2.5 cm.  The overlying skin measures 4.2 x 1.8 cm, and the specimen is inked as follows: superior-red, inferior-yellow, anterior-blue, posterior-black. The specimen is serially sectioned from. medial to lateral, revealing a firm, ill-defined mass measuring roughly 1 x 0.7 x 0.7 cm. The mass is 0.7 cm from the anterior margin, 1.2 cm from the. superior margin, 2.3 cm from inferior margin, 1.6 cm from the posterior. margin, 3 cm from the medial margin, and 4 cm from the lateral margin. The remainder of the specimen is composed of yellow fibroadipose tissue with thin delicate bands of breast tissue, no other lesions are identified.. BLOCK SUMMARY: D1-2- medial margin, bisected D3- superior portion of fourth slice from medial, thinned D5-6- anterior middle portion of fourth slice, thinned D7-8- posterior middle portion of fourth slice, thinned D9-10-~ inferior portion of fourth slice, thinned D11-12- superior portion of fifth slice, thinned D13-14- anterior middle section of fifth slice, thinned D15-16- posterior middle portion of fifth slice, thinned. D17-18- inferior portion of fifth slice, thinned D19- superior portion of sixth slice, thinned D20- anterior middle portion of sixth slice, thinned D21- posterior middle portion of sixth slice, thinned. D22- inferior portion of sixth slice, thinned D23- superior portion of seventh slice, thinned D24- middle portion of seventh slice, thinned D25- inferior portion of seventh slice, thinned D26- lateral margin MICROSCOPIC EXAMINATION: Microscopic examination is performed. PATHOLOGIC STAGE:S PROCEDURE: LEFT PARTIAL MASTECTOMY AND SENTINEL LYMPH NODE DISSECTION.
+
+--- Page 2 ---
+PATHOLOGIC STAGE (AJCC) Edition): pT1b pN0(sn)(i-) pMX Nore: Information on pathology stage and the operative procedure is transmitted to this Institution's Cancer Registry as required for. accreditation by the Commission on Cancer. Pathology stage is based solely upon the current tissue specimen being evaluated, and does not incorporate information on any specimens submitted separately to our Cytology section, past pathology information, imaging studies, or clinical or operative findings. Pathology stage is only a component to be considered in determining the clinical stage, and should not be confused with nor substituted for it. The exact operative procedure is available in the surgeon's operative report. DIAGNOSIS : A. "SENTINEL NODE #1" (EXCISION): ONE LYMPH NODE WITH NO EVIDENCE OF METASTATIC CARCINOMA (O/1).) AN IMMUNOHISTOCHEMICAL STAIN FOR CYTOKERATIN IS NEGATIVE FOR TUMOR CELLS.S "SENTINEL NODE #2" (EXCISION): B ONE LYMPH NODE WITH NO EVIDENCE OF METASTATIC CARCINOMA (O/1). AN IMMUNOHISTOCHEMICAL STAIN FOR CYTOKERATIN IS NEGATIVE FOR TUMOR CELLS. C. "SENTINEL NODE #3" (EXCISION): ONE LYMPH NODE WITH NO EVIDENCE OF METASTATIC CARCINOMA (O/1) .) AN IMMUNOHISTOCHEMICAL STAIN FOR CYTOKERATIN IS NEGATIVE FOR TUMOR CELLS. D. "LEFT BREAST" (PARTIAL MASTECTOMY) : INVASIVE ADENOCARCINOMA OF THE BREAST. HISTOLOGIC TYPE: LOBULAR. NOTTINGHAM COMBINED HISTOLOGIC GRADE: 2 OF 3. TUBULE FORMATION SCORE: 3 NUCLEAR PLEOMORPHISM SCORE: 2 MITOTIC RATE SCORE: 2 GROSS TUMOR SIZE: 1 X 0.7 X 0.7 CM. SIZE OF INVASIVE COMPONENT: 1 CM. LYMPHATIC/VASCULAR INVASION: ABSENT. MULTIFOCAL TUMOR: ABSENT. IN-SITU CARCINOMA: PRESENT. TYPE OF IN-SITU CARCINOMA: DUCTAL, SOLID TYPE. NUCLEAR GRADE OF IN-SITU CARCINOMA: 2 OF 3. NECROSIS: ABSENT. DCIS EXTENDING OUTSIDE INVASIVE TUMOR MASS: PRESENT, AT EDGE OF TUMOR. STATUS OF NON-NEOPLASTIC BREAST TISSUE: BIOPSY SITE CHANGES, FIBROCYSTIC CHANGE. SKIN STATUS: NEGATIVE FOR MALIGNANCY. SIZE OF BIOPSY: 7.5 X 6 X 2.5 CM. MICROCALCIFICATIONS: PRESENT IN ASSOCIATION WITH CARCINOMA AND BENIGN BREAST TISSUE. SURGICAL MARGIN STATUS: NEGATIVE. INVASIVE CARCINOMA PRESENT O.9 CM FROM THE ANTERIOR MARGIN. ESTROGEN/PROGESTERONE RECEPTOR, CELL CYCLE, EGFR AND HER2/NEU ANALYSIS: NOT PERFORMED (SEE PREVIOUS BIOPSY REPORT is not. comMENr: The ductal component from the needle core biopsy. obvious in the resection specimen. The tumor contains areas of classic. lobular carcinoma as well as more solid areas that are comprised of small nests of tumor cells which are interpreted as an acinar/solid component.. I certify that I personally conducted the diagnostic evaluation of the above.
+
+--- Page 3 ---
+ragc 5 U1 5 specimen(s) and have rendered the above diagnosis(es). Electronically signed Performed by:
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diff --git a/output/text/ef355091-e27f-4f25-a0f3-a93ea82a486b.txt b/output/text/ef355091-e27f-4f25-a0f3-a93ea82a486b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e52e5f38f8abd80508e48d902514d625bdf99ca4
--- /dev/null
+++ b/output/text/ef355091-e27f-4f25-a0f3-a93ea82a486b.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Ics-0-3 CaLcinoma,if/thstng duct. N0s 85o0/3 Si#: brt No5 c50.9 4/a7/11  UUID:CCE33A9S-774E-4242-B2A1-05FF002ED1D9 TCGA-A7-A26I-01A-PR Redacted Date Coll: SURGICAL PATHOLOGY REPORT SPECIMEn A. Left axillary sentinel node B. Left breast mass.  Long stitch anterior, short stitch superior CLINICAL NOTES PRE-OP DIAGNOsIS: Left breast cancer CLINICAL HISTORY: year-old white female with breast cancer POST-OP DIAGNOSIS:  Left breast cancer. GROSS DESCRIPTION A. Received fresh labeled "left axillary sentinel nodes" with lymph nodes measuring 0.6 and 1.0 cm. in greatest dimension. The specimens are bisected and entirely submitted independently in two blocks (one bisected tissue per cassette). B. Received fresh within a Transpec container labeled "left breast mass" is a 7.3 cm. (medial to lateral) x 6.5 cm. (superior to inferior) x 3.7 cm. (anterior to posterior), soft, lobulated tan gold-white portion of fibroadipose tissue with two sutures as stated previously. The margins are inked as follows: Anterior - blue, posterior - black, superior - green, and inferior Orange.  The specimen is sectioned from medial to lateral. There is a central, moderately well-circumscribed, 3.2 cm. (medial to lateral) x 2.5 cm. (superior to inferior) x 2.4 cm. (anterior to posterior), firm tan white tumor mass with several central. associated cylindrical tan white structures in keeping with cyte of prior needle core biopsy. A portion of tumor and a portion of normal parenchyma are submitted for tissue procurement as requested. The tumor appears to focally extend to within 0.3 cm. of both the anterior and posterior inked margins. The cut surfaces throughout the remainder of the specimen consist predominantly of glistening lobulated golden yellow adipose tissue with a minimal amount of interspersed dense tan-white fibrous tissue.  No additional abnormality is noted.  Representative sections are submitted in a sequential manner from medial to lateral in 10 blocks as labeled. BLOCK SUMMARY:  1 - Representative perpendicular sections medial. margin cap; 2-9 sequential sections; 10 - representative perpendicular sections lateral margin cap. MICROSCOPIC DESCRIPTION A.  Microscopic examination involved the evaluation of the four H&E stained sections of each of the tissue blocks. Also pan cytokeratin AEl/AE3 immunohistochemical stains were evaluated of each tissue block and no metastatic tumor was. identified in any of the examined sections (0/2) (snpn0).  Microscopic examination of the left breast lumpectomy specimen reveals:
+
+--- Page 2 ---
+Invasive Carcinoma: Present. Histologic type: Infiltrating ductal.. Histologic grade: Elston's sBR grade 2. Overall grade: Architectural score: Nuclear score: 2 Mitotic score: 2 Greatest  dimension (pT): 3.2 cm. in greatest dimension (pT2). Specimen margins:  The resection margins are negative for. carcinoma with the closest resection margins being superior and. anterior where invasive tumor is 2 mm. from the resection. margin.  Tumor is 3 mm from the posterior resection margin. Vessel invasion:  Not identified. Calcification: Present. Ductal carcinoma in situ: Present.. Histologic pattern:  Solid with cancerization of lobules.. Nuclear grade: High grade. Central necrosis: % Dcis of total tumor (if mixed): Less than 10%. Extensive intraductal component (present/absent): Absent. Specimen margins: Dcis is 2 mm from the anterior and superior margins and 3 mm from the posterior margin. Calcification: not identified.. and microcysts with sclerosing adenosis. Prognostic markere. H-y. been reported previously on the core. biopsy see 4x2, 20x1 DIAGNOSIS A. Left axillary sentinel lymph nodes, biopsy:. Two lymph nodes negative for metastatic tumor (0/2). B. Left) breast, lumpectomy: Invasive ductal carcinoma, Elston's sBR grade 2, tumor size. 3.2 cm. Associated high grade solid ductal carcinoma in-situ. Invasive and in-situ carcinoma are 2 mm from the resection. margins designated superior and anterior and 3 mm from the. resection margin designated posterior. No lymphovascular space invasion identified.. See microscopic description.. (Electronic Signature)  End Of Report
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diff --git a/output/text/ef408c81-1b8e-4620-aee3-608201f88509.txt b/output/text/ef408c81-1b8e-4620-aee3-608201f88509.txt
new file mode 100644
index 0000000000000000000000000000000000000000..145b82d9ded0c54c02aa6ffc3158f832a8862400
--- /dev/null
+++ b/output/text/ef408c81-1b8e-4620-aee3-608201f88509.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Surgery Date: UUID:92DF9BB6-DB3F-40A7-AE1E-8272C46B1968 Redacted Diagnosis ***Amended Report**** This report was changed to correct staging summary.. Previously signed out on by COLORECTAL I APPENDICEAL (INCLUDING GOBLET CELL CARCINOID ONLY) CANCER STAGING SUMMARY LCDD-3 TOTAL LYMPH NODES: 21 LsLencCaeunoma NtS 8i4cf3 NUMBER OF POSITIVE: 5 C18.0 Site: Cseun R/4[14 Previously reported as: Final Diagnosis A. RIGHT COLON, LAPAROSCOPIC RIGHT HEMICOLECTOMY: INFILTRATING COLONIC ADENOCARCINOMA, GRADE 2, MEASURING 11.2 CM IN GREATEST DIMENSION AND INVADING THROUGH THE MUSCULARIS PROPRIA INTO PERICOLONIC FAT ALL MARGINS OF RESECTION NEGATIVE FOR CARCINOMA FIVE OF TWENTY-ONE LYMPH NODES, POSITIVE FOR METASTATIC ADENOCARCINOMA (5/21). APPENDIX WITH ACUTE APPENDICITIS COLORECTAL I APPENDICEAL (INCLUDING GOBLET CELL CARCINOID ONLY) CANCER STAGING SUMMARY TUMOR SITE: CECUM, TERMINAL ILEUM HISTOLOGIC TYPE: ADENOCARCINOMA GROSS CONFIGURATION: POLYPOID AND ULCERATED TUMOR SIZE: 11.2 CM IN GREATEST DIMENSION TUMOR GRADE: 2 DEPTH/EXTENT OF TUMOR INVASION: PERICOLONIC FAT COEXISTING ADENOMA TYPE: NOT IDENTIFIED MARGINS (PROXIMAL, DISTAL, RADIAL): NEGATIVE PERINEURAL INVASION: NOT IDENTIFIED LYMPHOVASCULAR INVASION: NOT IDENTIFIED SATELLITE TUMOR DEPOSITS*: NO 20 TOTAL LYMPH NODES: NUMBER OF POSITIVE: 4 TUMOR MARKER STUDIES: UPON REQUEST American Joint Committee on Cancer (AJCC) 7th Edition Tumor-Nodes-Metastasis (TNM) staging for colorectal/appendiceal cancers:. Tumor (T): T3 Nodes (N): N2a Metastasis (M): MX Page 1 of 3
+
+--- Page 2 ---
+Surgery Date: *SATELLITE TUMOR DEPOSIT IS DEFINED AS TUMOR NODULE IN THE PERICOLORECTAL ADIPOSE SOFT TISSUE THAT IS SEPARATED FROM THE MAIN TUMOR  MASS AND DOES NOT DEMONSTRATE A SMOOTH OUTLINE CONTOUR. IT MAY REPRESENT DISCONTINUOUS SPREAD OR VENOUS INVASION OF THE TUMOR A COMPLETELY REPLACED LYMPH NODE (SMOOTH CONTOUR WITH CAPSULE, SINUS AND LYMPHOID CUFF FOCALLY IDENTIFIED) IS EXCLUDED FROM THIS CATEGORY AND SHOULD BE COUNTED IN THE N CATEGORY. Tis: CARCINOMA IN-SITU, INTRAEPITHELIAL OR INVASION OF LAMINA PROPRIAE T1: TUMOR INVADES SUBMUCOSAE THROUGH THE MUSCULARIS PROPRIA INTO PERICOLORECTAL TISSUES HE VISCERALPERITONEUM T4b: TUMOR DIRECTLY INVADES OR IS ADHERENT TO OTHER ORGANS OR STRUCTURES NO:NO INODE METASTASIS PERITONEALIZED PERICOLIC OR PERIRECTAL TISSUES WITHOUT REGIONAL NODE METASTASIS N2a: 4 TO 6 NODES INVOLVED BY METASTASIS N2b: 7 OR MORE NODES INVOLVED BY METASTASIS M1a METASTASIS TO A SINGLE ORGAN OR SITE (LIVER, LUNG, OVARY, NON-REGIONAL LYMPH NODE) M1b METASTASIS TO MORE THAN ONE ORGAN/SITE OR TO PERITONEUM (Electronically signed by) Date Finaled: I, the Attending Pathologist attest by my signature, that this case. has been personally reviewed and examined, microscopically and/or grossly. and the diagnosis(es) has been made or confirmed by me. Clinical Information The patient is a  -year-old male with clinical diagnosis of colon cancer, undergoing laparoscopic right hemicolectomy.. Gross Description A. The specimen is received fresh intraoperatively for consultation from. , labeled with the patient's name and designated on the requisition as "right colon, frozen for margins, rest routine," and consists of a segment of right colon measuring 6.5 cm in length and averaging 5 cm in diameter with an attached portion of ileum, measuring 8.5 cm in length and averaging 3 cm in diameter. The appendix is present and measures 7.2 x 1.2 x 1.0 cm and appears slightly dilated in its midportion. The specimen is opened to reveal a large polypoid fungating mass measuring 11.2 x 6.8 x 1.9 cm, which involves the cecum and a small portion of the terminal ileum. The mass is 8 cm from the proximal margin at its closest point and 6.5 cm from the distal margin at its closest point. A shave of the distal margin is frozen. The frozen section diagnosis by is "DISTAL MARGIN, NEGATIVE FOR CARCINOMA." The intraoperative consultation diagnosis is communicated to the operating room at After frozen section, the area under the tumor is inked black and the tumor is serially sectioned to reveal that it appears to extend through the colonic wall and into the pericolonic fat, but not to the inked margin. Additionally, there is a large mass, consistent with matted lymph nodes, in the pericolonic fat, which measures 6.5 x 4.5 x 3.5 cm. The specimen is representatively submitted as follows: 1 -2 shave of distal margin (frozen residues) 3 shave of proximal margin 4 base of appendix and tip, bisected. 5 representative sections from midsection of appendix (appears dilated) 6-8 tumor with apparent extension into pericolonic fat 9 - 10 tumor with relationship to inked margin Page 2 of 3
+
+--- Page 3 ---
+Surgery Date: 11 representative section from grossly positive lymph node 12 one lymph node, bisected 13 representative sections from another grossly positive lymph node 14 representative sections from a third grossly positive lymph node 15 grossly positive lymph node vs soft tissue tumor deposit 16 two possible lymph nodes 17 one lymph node, bisected 18 three possible lymph nodes 19 three possible lymph nodes 20 two possible lymph nodes 21 two possible lymph nodes Frozen Section Diagnosis A. "DISTAL MARGIN, NEGATIVE FOR CARCINOMA." lw 11s[3 Page 3 of 3
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diff --git a/output/text/ef56e401-81cd-4abf-8777-858e7bc1792e.txt b/output/text/ef56e401-81cd-4abf-8777-858e7bc1792e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0674d660c44bf40747235257836f67f51efe806d
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+
+--- Page 1 ---
+UUID:4A5630FF-0ADC-4E69-B22A-02F1F34F61F9 TCGA-A2-A4S2-01A-PR Redacted Name Age/Sex.:.. /E Location Acct#: wwnit# Status... Room/Bed: Reg: Disch M.D Specimen: Received: Status: Reg# : Collected: Sp type: SURGICAL P Subm Dr: 'I.D. PREOPERATIVE DIAGNOSIS CANCER OF THE RIGHT BREAST AND AXILLARY NODES OPERATION PERFORMED DATE: 1es-0-3 DOCTOR(S) : PROCEDURE :  MASTECTOMY MODIFIED RADICAL carciiwmn, infltnnfrg 1obulw mmxeL wiH othu+ypw 85x4f3 TISSUE REMOVED. (SiqntRrm9) A. RIGHT BREAST B. RIGHT AXILLARY CONTENTS S1fxr Brst Nos c5s.9 GROSS DESCRIPTION 10/31 RECEIVED IN 2 PARTS. PART A RECEIVED LABELED RIGHT BREAST DOUBLE BLACK STITCH 12 O'CLOCK AT NIPPLE IS A 1,416 GRAM MASTECTOMY MEASURING 28.5 CM FROM MEDIAL TO LATERAL, 26.5 CM FROM SUPERIOR TO INFERIOR, AND UP TO 6 CM FROM ANTERIOR TO POSTERIOR.  A SUTURE DENOTES 12 O'CLOCK.  THE NIPPLE IS FLAT WITH THE SURROUNDING AREOLA MEASURING 6 CM IN DIAMETER. IN THE UPPER OUTER QUADRANT 6 CM FROM THE NIPPLE THERE IS A O.3 CM ULCERATION. 0.5 CM IN GREATEST DIMENSION. THIS IS 16 CM FROM THE NIPPLE.  THE SKIN ELLIPSE MEASURES 25.6 X 11.5 CM.. THERE IS A PALPABLE MASS AT 12 O'CLOCK. "MRM" IS WRITTEN ON THE SPECIMEN AT 12 O'CLOCK. THE ANTERIOR MARGIN IS MARKED BLUE AND THE DEEP IS MARKED BLACK. SECTIONING REVEALS THE MAJORITY OF THE BREAST TO CONSIST OF BLAND YELLOW FATTY TISSUE WITH FINE FIBROUS BANDS. THERE ARE BROADER AREAS OF FIBROSIS IN THE MORE CENTRAL ASPECT OF THE SPECIMEN. IN THE 12-1 O'CLOCK AREA THERE IS A FIRM GRAY-TAN MASS WHICH IS GREATER THAN 1 CM FROM THE DEEP MARGIN MEASURING 5.8 CM FRCM SUPERIOR TO INFERIOR, 2.5 CM FROM ANTERIOR TO POSTERIOR, AND 4 CM FRCM MEDIAL TO LATERAL.  CENTRALLY THERE IS AN IRREGULAR AREA OF RED-BROWN DISCOLORATION. THIS IS ALSO GREATER THAN 1 CM FROM THE OVERLYING SKIN. A COIL CLIP IS IDENTIFIED WITHIN THE LESION.  SECTIONS ARE SUBMITTED AS FOLLOWS:  A1--NIPPLE, A2--SKIN ULCERATIONS AND 12 O'CLOCK SKIN MARGIN, A3--DEEP MARGIN TO CENTRAL LESION, A4~-ANTERIOR MARGIN TO CENTRAL LESION, A5 THROUGH A7--A SUPERIOR TO INFERIOR CROSS SECTION THROUGH THE LESION AT LEVEL OF CLIP, A8--THE MOST MEDIAL ASPECT OF LESION, A9--MOST LATERAL ASPECT OF LESION, A1O AND
+
+--- Page 2 ---
+(Continued) Raceived: Status: Req#: Specimen: Collected: Sp type:  SURGICAL P M.D. Subn Dr (Continued) 11--ADDITIONAL SECTIONS OF MASS, A12--UPPER INNER QUADRANT 4 CM FROM LESION, A13~-UPPER OUTER QUADRANT 5 CM FROM LESION, A14--LOWER OUTER QUADRANT 5 CM FROM LESION, A1S--LOWER INNER QUADRANT 4 CM FROM LESION, A16--TISSUE DEEP TO NIPPLE AT MEDIAL EDGE OF LESION. --NOTE:---TISSUE--IS--SUBMITTED--PER--CLINICAL--BREAST-- CARE--PROJECT--RESEARCH PROTOCOL OF THE TUMOR LABELED P1-P1O AND MIRROR IMAGE SECTIONS OF THE NIPPLE (A1) AND THE RANDOM QUADRANT SECTIONS (A12-A15) ARE SUBMITTED FROZEN IN CCT. PART B RECEIVED LABELED AXILLARY CONTENTS ARE 4 FRAGMENTS OF YELLOW-PINK FATTY TISSUE TOGETHER MEASURING 1O X 7.S X 1.5 CM. THE SPECIMEN IS THEN EXAMINED FOR LYMPH NODES. ALONG ONE EDGE OF THIS SPECIMEN THERE ARE STRANDS OF RED MUSCLE FIBERS. EXAMINATION REVEALS 8 NODAL STRUCTURES. THESE ARE SUBMITTED AS FOLLOWS. FOUR (4) OF THESE MEASURE LESS THAN O.5 CM AND ARE SUBMITTED AS BI.  ONE OF THE LARGER NODES IS GROSSLY POSITIVE, ONE-HALF IS SUBMITTED IN B2, THE MIRROR IMAGE AS P11 PER THE CLINICAL BREAST CARE PROJECT RESEARCH PROTOCOL. THE REMAINING 3 LARGE NODES ARE EACH SUBMITTED BISECTED AND SEPARATELY LABELED B3 THROUGH B5. B6 IS REPRESENTATIVE MUSCLE.  A BIOPSY CLIP IS NOT GROSSLY IDENTIFIED. COMMENT : THIS CASE IS IN COMPLIANCE WITH CAP/ASCO GUIDELINES OF 6-48 HOURS FORMALIN FIXATION TIME. PATH PROCEDURES PROCEDURES : 88309, A BLK/16, B BLK/6 FINAL DIAGNOSIS PART A RIGHT BREAST, SIMPLE MASTECTOMY: per Tss, SigNetring lompevsnt <10% 1 LC 3[2]1 1. INTRALOBULAR AND INFILTRATING LOBULAR CARCINOMA WITH SIGNET-RING CELL DIFFERENTIATION, GRADE II SHOWING NUCLEAR GRADE 2/3 AND LOW signtrung dill MITOTIC INDEX. LCIS OF THE CLASSIC TYPE SHOWS NUCLEAR GRADE 1 5.8cm0 COMPRISING APPROXIMATELY 5% OF THE TUMOR. 5% hC|5 2. THE INVASIVE CCMPONENT HAS A MAXIMUM GROSS DIMENSION OF 5.8 CM classic WITHIN THE CENTRAL PORTION OF THE BREAST WHICH EXTENDS INTO THE
+
+--- Page 3 ---
+Patient: (Continued) Specimen: Received: Status: Req#: Collected: Sp type: SURGICAL P Subm Dr: I.D. ADDENDUM. (Continued) METASTATIC CARCINOMA IS IDENTIFIED IN ONE OF FOUR ADDITIONAL AXILLARYS LYMPH NODES INCLUDING EXTENSION OF TUMOR INTO THE EXTRANODAL SOFT TISSUE /1/4). A SEPARATE AREA HAVING BIOPSY CHANGES IS ALSO PRESENT. eNX Dictated by Addendum Signec On file) M.d. Signed Electxonically signed by:. M.D.
+
+--- Page 4 ---
+(Continued) Patient: tus: Req#:  Received: Collected: : Sp type: SURGICAL P Subm Dr: .D. FINAL DIAGNOSIS... (Continued) RETICULAR DERMIS UNDERLYING THE NIPPLE SKIN. 3. THE NIPPLE SKIN, SKIN AND BREAST MARGINS OF RESECTION, AND RANDOM SECTIONS FROM THE REMAINING QUADRANTS ARE FREE OF TUMOR WITH THE CLOSEST LOCATED 4 MM FROM THE NEAREST INKED DEEP MARGIN (A3) . 4LV1 4.  LYMPHOVASCULAR INVASION IS IDENTIFIED. 5. FIBROCYSTIC CHANGES INCLUDING SCLEROSING ADENOSIS, MICROCYST Fc sA FORMATION AND PATCHY DENSE STROMA. Ca# CA+B9 6. CALCIFICATIONS ARE SEEN WITHIN THE TUMOR AS WELL AS BENIGN PORTIONS OF THE BREAST. pop 7. SCLEROTIC INTRADUCTAL PAPILLOMA. 13 x 8. BIOPSY CHANGES : ARE IDENTIFIED. 9. SMALL SKIN ULCERATIONS (2). PART B  RIGHT AXILLA, LYMPH NODE DISSECTION: METASTATIC BREAST CARCINOMA IS IDENTIFIED IN 4 OF 6 AXILLARY LYMPH NODES EXAMINED (4/6) . EXTENSION OF TUMOR INTO THE PERINODAL SOFT TISSUE INVOLVES THE LARGEST AREA OF METASTATIC TUMOR WHICH MEASURES 1.1 CM IN GREATEST E nx MICROSCOPIC DIMENSION. A REPRESENTATIVE SECTION OF SKELETAL MUSCLE IS NEGATIVE FOR TUMOR.  BIOPSY CHANGES ARE NOT IDENTIFIED GROSSLY OR MICROSCOPICALLY IN THE NODAL DISSECTION.S ADDENDUM Addendum #l Entered: THE LATERAL UPPER OUTER QUADRANT IS RE-EXAMINED AND A WING CLIP IS IDENTIFIED IN AN AREA OF FATTY TISSUE, WITH THE TISSUE ANTERIOR HAVING A YELLOW-WHITE INDURATION CONSISTENT WITH A PREVIOUS BIOPSY AREA. THE AREA OF THE CLIP PROPER IS SUBMITTED IN A17 AND 18.  THE TISSUE ANTERIOR TO THIS AREA IS SUBMITTED IN A19 AND 20.  LATERAL TO THIS, THERE IS A GROSSLY POSITIVE NODAL STRUCTURE O.6 CM IN DIAMETER. THIS IS SECTIONED AND SUBMITTED IN A21. AN ADDITIONAL POSSIBLE NODE IS SUBMITTED IN A22 AND 23.  AN ADDITIONAL POSSIBLE O.4 CM NODE IS SUBMITTED IN A24.
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diff --git a/output/text/ef675744-bb2b-4443-94fc-4c38bfaad301.txt b/output/text/ef675744-bb2b-4443-94fc-4c38bfaad301.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4683d97225d9bcd016db0a2c0d613ef832aa544b
--- /dev/null
+++ b/output/text/ef675744-bb2b-4443-94fc-4c38bfaad301.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+-9DDE-45A8-A788-5EE2CEC6F6E4 TCGA-UB-AA0V-01A-PR Redacted Results Surgical Pathology Specimen Source (enter 1 per line): 1. left lobe of liver-permanent (long stitch marks lateral; smedium stitch marks medial) (Order. Result Information Status (Last updated Date/Time) BDO NQS Edited Accession # 8170/3 perjslasias, focel msoluear Site sLsier 0gx.Z SURGICAL PATHOLOGY REPORT *AMENDED* Patient Name. Med. Rec.#: Sex: Aacession #: Visit #: Service Date: Received: Location: Client: Physician(s) : FINAL PATHOLOGIC DIAGNOSIS Liver, left lobe, partial hepatectomy:. l. Focal nodular hyperplasia; see comment.. 2.Minimal hemosiderosis: see comment. COMMENT: This report has been amended due to'a typographical error in the. diagnosis. The diagnosis and report remain otherwise unchanged. Sections reveal a circumscribed, nodular proliferation of. well-differentiated hepatocytes with associated thin, irregular fibrous bands' demonstrating ductular reaction and aberrant arterioles, which focally abuts the hepatic capsule. The hepatocytes show intact trabecular architecture wirhout cytologic atypia. Reticulin stain (performed on block A3) highlights hepatic plates ot 1-2 cel1 thickness and shows no loss. The surgical margin is negatiye. In order to further characterize the lesion. immunohistochemical stains were performed on block A3, with the following results in the lesional.. hepatocytes: - Glutamine synthetase: Positive in characteristic patchy, map-like staining pattern. -SAA: Negative.
+
+--- Page 2 ---
+- Crp: Focal weak positive; predominantly negative. -L-FABp: Positive (normal pattern).. -Beta-catenin: Membranous staining only (normal pattern). - In addition, an inununostain for CD34 shows patchy sinusoidal endothelialization near fibrous septae.. The morphologic and immunohistochemical findings are those of excised focal nodular hyperplasia (FNH). The non-lesional hepatic parenchyina shows few widely scattered portal. tracts with minimal predominantly lymphocytic inflammation without interface activity. Bile ducts are intact without injury or loss. There is no signiticant lobular inflammation, and no necrotic. hepatocytes are identified. Foci of glycogenated nuclei are seen. There is no steatosis or cholestasis. A trichreme stain (performed on block A5) overall shows no significant increased fibrosis; a few thin, periportal septae are identified, but these are focal and subcapsular in location. An iron stain (also performed on block A5), shows widely. scattered small, patchy foci of 1-2+ staining, predominantly in hepatocytes and also in Kupffer cells (scale 0-4), some but not all of which show periportal distribution... The findings in the background liver are minimal and non-specific. The pattern of minimal iron deposition is not entirely specific but may be. compatible with genetic hemochromatosis in this context. Selected slides of this case have also been reviewed by Dr. (Al, A3, and A4, including immunostains) and Dr. (slide A5, including iron and trichrome stains), who aqree with the diagnosis.. Specimen(s) Received A:Left lobe of liver-permanent (long stitch marks lateral; medium stitch maxks medial) (FS) Intraoperative Diagnosis Fs1 (A) Liver, left lobe, biopsy: Hepatocellular lesion, differential diagnosis includes focal nodular hvnonlasia and variant adenoma. Dr. .agrees. (Dr. Clinical History The patient is a year-old woman who, according to. ,has a known history of hemochromatosis (c282y homozygous) and developed a 2 cm lesion in segment 2 of the liver, and had elevated alpha-fetoprotein. There is no cirrhosis on imaging studies.. Gross Description The case is received in one part, fresh, labeled with the patient's name and medical record number, and additionally labeled "#1 left: lobe liver," and consists of a portion of liver (55. gm; 7 cm from right to left x 2.8 cm from anterior to posterior x 10 cm from superior to inferior). GROss ABnORMALITIEs: There is a firm, well-circumscribed, yellow-brown. nodule (2.2 x 2 x 1.8 cm, loated 1 cm from the parenchymal margin.
+
+--- Page 3 ---
+The nodule abuts the capsule and is 3.5 cm from the lateral edge. The vessels and ducts surrounding the nodule are patent. The surrounding parenchyma is uniformly pink-brown without other masses. No candidate. lymph nodes are identified. ORIenTeD By: Surgeon's sutures; short - modial, long - lateral. INTRAOPERATIVE FINDINGS: Frozen section l; nodule, subsequently submitted in cassette Al.. INKING: Liver capsule overlying mass: Blue. - Parenchymal margin: Black. POTeNTIAL sruDIes: Fresh normal tissue and tumor are submitted to the Tissue Bank.. CASSETTES: Representative sections are submitted: Al: Frozen sedtion 1 remnant. A2 : Nodule and relationship to parenchymal margin.. A3-A4: Additional nodule. A5: Normal-appearing parenchyma, 3 cm from nodule.. The inmunohistochemical stains reported above were developed und their. performance. characteristics determined by the They have not. been cleared or approved by the. U.. 5. Food and Drug Administration. The FbA has determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 ("cLIA!) as qualified to perform high-complexity clinical testing.. Diagnosis based on gross and microscopic examinations. Final diagnosis. made by attending pathologist following review of all pathology slides.. The attending pathologist has reviewed all dictations, including prosector work, and preliminary interpretations performed by any. resident involved in the case and performed all necessary edits before. signing the final report. Pathology PDF Report Show images for Surgical Pathology Specimen Source (enter 1 per line): 1. left lobe of liver-permanent (long stitch marks lateral: smedium stitch marks medial) Authorizing Provider Information Name: Fax: MD Phone: Pager: Signed by Result History. SURGICAL PATHOLOGY (Order Order Result History Report.. and Items Surgical Pathology Specimen Source (enter 1 per line): 1. left lobe of liver-permanent (long stitch marks lateral: smedium stitch marks medial) (Order 1
+
+--- Page 4 ---
+This is NOT a Requisition. Requisition hyperlink below. Surgical Pathology Specimen Source (enter 1 per line): 1. left lobe of liver-permanent (long stitch Authorizing: marks lateral; smedium stitch marks medial) Date. (Order MD Released By: Pathology and Cytology Department: Order: Show images for Surgical Pathology Specimen Source (enter 1 per line): 1. left lobe of liver-permanent (long stitch marks lateral; smedium stitch marks medial) Order Information Order Date/Time Release Date/Time Start Date/Time End Date/Time Release Information. Released On  Released By Order Details Frequency Duration Priority Order Class Once 1 occurrence. Routine Unit Collect Order Questions Question Answer Conment COLLDATE COLLTIME ORPHONE Specimen Source (enter 1 per line). 1. left lobe of liver! permanent (long stitch marks lateral; smedium stitch marks medial) liver mass Lab Collection and Receipt Information. Collected By Lab Receipt Date Lab Receipt Time Collect Date Collect Time Collection Information Resulting Agency Order Provider Info Office phone Pager/beeper E-mail. Ordering User Authorizing Provider Electronically Signed By:. Electronically Authorized By. Electronically Ordered By
+
+--- Page 5 ---
+Acknowledgement Info For At Acknowledged By Acknowledged On Order Status for: SURGICAL PATHOLOGY Parent Status: Completed Child Orders (This order does not yet have any children) Order Requisition Surgical Pathology Specimen Source (enter 1 per Jine): 1. left lobe of liver-permanent (long stitch marks lateral: smedium stitch marks medial) (Order 8CA hw 1/3/4
+
+--- Page 6 ---
+V4.00 TCGA Pathologic Diagnosis Discrepancy Form Instructions: The TCGA Pathologic Diagnosis Discrepancy Form should be completed when the pathologic diagnosis. documented on the initial pathology report for a case submitted for TcGA is inconsistent with the diagnosis provided on the Case Quality Control Form completed for the submitted case. Tissue Source Site (TsS): TSS Identifier: TSS Unique Patient Identifier: Completed By (Interviewer Name on ' Completed Date: Diagnosis Information # Data Element Entry Alternatives Working Instructions Provide the diagnosis/ histologic subtype(s) documented on  Pathologic Diagnosis Focal nodular the initial pathology report for this case. If the histology for Provided on Initial this case is mixed, provide all listed subtypes. hyperplasia Pathology Report Histologic features of Provide the histologic features selected on the TCGA Case Hepatocellular Quality Control Form completed for this case. the sample provided 2 for TCGA, as reflected carcinoma on the CQCF. Discrepancy between Pathology Report and Case Quality Control Form  Provide the reason for The frozen section top slide was Provide a reason describing why the diagnosis on the initial.  the discrepancy pathology report for this case is not consistent with the consistent with a well- diagnosis selected on the TCGA Case Quality Control Form.  between the pathology differentiated hepatocellular report and the TCGA Case Quality Control lesion, and immunostains Form. (including beta-catenin and glutamine synthetase) and reticulin stain were required to. differentiate between hepatocellular carcinoma, hepatic. adenoma, and focal nodular hyperplasia (which ended up being the final pathologic diagnosis). Name of TsS Reviewing  Provide the name of the pathologist who reviewed this case for TCGA. Pathologist or  Biorepository Director I acknowledge that the above information provided by my institution is true and correct and has been quality controlled. Tss Reviewing Pathologist or Biorepository Director Date I acknowledge that the above information provided by my institution is true and correct and has been quality controlled. The Attending Pathologist or the Department Chairman has been informed or is aware of the above discrepancy in diagnoses.. Princi restigator Signature Date
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diff --git a/output/text/ef76fc0b-fb9e-4d0e-9973-098b6e008a9b.txt b/output/text/ef76fc0b-fb9e-4d0e-9973-098b6e008a9b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f87c2c678f39a065b2750e6f80b72b4c8ce9d87b
--- /dev/null
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+--- Page 1 ---
+Page 1 of 5 UUID:1276CC52-8D49-40E9-A365-3E065E1B77EA TCGA-XF-A8HF-01A-PR Redacted Collecte CLINICAL DIAGNOSIS: Bladder cancer FINAL DIAGNOSIS: RADICAL CYSTECTOMY WITH URINARY DIVERSION TO SKIN GT PLACEMENT: Icd O 3 RIGHT URETER (A) : Carenoino, transtinalcese NcS FROZEN SECTION DIAGNOSIS: NO TUMOR IDENTIFIED 8120/3 FINAL DIAGNOSIS: Site MBludder NsSEc7.9 BENIGN URETER  NO HIGH UROTHELIAL ATYPIA OR TUMOR IDENTIFIED y 1123114 LEFT URETER (B): FROZEN SECTION DIAGNOSIS: NO TUMOR IDENTIFIED FINAL DIAGNOSIS: BENIGN URETER  NO HIGH GRADE UROTHELIAL ATYPIA OR TUMOR IDENTIFIED PROSTATE AND BLADDER (C) : PROSTATE: BILATERAL PROSTATIC ADENOCARCINOMA, GLEASON' S SCORE 7 (3+4). EXTENDS INTO THE PROSTATIC CAPSULE BUT NOT THROUGH IT ALL MARGINS ARE FREE OF TUMOR PERINEURAL INVASION IDENTIFIED NO LYMPHOVASCULAR SPACE INVASION IDENTIFIED BILATERAL SEMINAL VESICLES AND VASA DEFERENTIA, FREE OF TUMOR HIGH GRADE PROSTATIC INTRAEPITHELIAL NEOPLASIA (PIN III) BLADDER: INVASIVE POORLY DIFFERENTIATED TRANSITIONAL CELL CARCINOMA (3.0 X 2.2 X 1.0 CM). GRADE 4/4, EXTENDING THROUGH THE LEFT POSTERIOR BLADDER WALL INTO PERIVESICAL TISSUE MICROSCOPICALLY NO LYMPHOVASCULAR TUMOR INVASION IDENTIFIED EXTENSIVE TUMOR NECROSIS LOCATED ADJACENT TO FUNGATING MASS LESION NO IN SITU CARCINOMA (FLAT LESION) IDENTIFIED  MARGINS OF RESECTION, FREE OF UROTHELIAL ATYPIA AND TUMOR LEFT LYMPH NODE CLOQUET (D):  NO METASTATIC CARCINOMA IDENTIFIED IN ONE LYMPH NODE (O/1) LEFT OBTURATOR LYMPH NODES (E) : NO METASTATIC CARCINOMA IDENTIFIED IN FOUR LYMPH NODES (O/4) LEFT HYPOGASTRIC LYMPH NODES (F) : NO METASTATIC CARCINOMA IDENTIFIED IN THREE LYMPH NODES (O/3) PRESACRAL LYMPH NODES (G) :  NO METASTATIC CARCINOMA IDENTIFIED IN TWO LYMPH NODES (O/2) LEFT COMMON ILIAC LYMPH NODES (H) : NO METASTATIC CARCINOMA IDENTIFIED IN THREE LYMPH NODES (O/3) RIGHT LYMPH NODE OF CLOQUET (I): NO METASTATIC CARCINOMA IDENTIFIED IN ONE LYMPH NODE (O/1) RIGHT OBTURATOR LYMPH NODE (J) :
+
+--- Page 2 ---
+Page 2 of 5 Orderedb NO METASTATIC CARCINOMA IDENTIFIED IN ONE LYMPH NODE (O/1) RIGHT EXTERNAL ILIAC LYMPH NODE (K) :  NO METASTATIC CARCINOMA IDENTIFIED IN ONE LYMPH NODE (O/1) RIGHT HYPOGASTRIC LYMPH NODE (L) : NO METASTATIC CARCINOMA IDENTIFIED IN ONE LYMPH NODE (0/1) RIGHT COMMON ILIAC LYMPH NODE (M) : NO METASTATIC CARCINOMA IDENTIFIED IN THREE LYMPH NODE (O/3) LEFT PROXIMAL URETER (N): BENIGN URETER NO UROTHELIAL ATYPIA OR TUMOR IDENTIFIED RIGHT PROXIMAL URETER (O) : BENIGN URETER  NO UROTHELIAL ATYPIA OR TUMOR IDENTIFIED PATHOLOGIC TNM STAGE:  Bladder cancer -pT3aNOMX Prostate cancer-pT2cNOMX INTRAOPERATIVE DIAGNOSIS: FROZEN SECTION DIAGNOSIS: AFs: Right ureter: no tumor identified. BFS: Left ureter: no tumor identified GROSS DESCRIPTION:  The specimen is received fresh from the O.R. and labeled "Right ureter." It A: consists of a segment of pink-tan ureter measuring 0.7 x 0.5 x 0.1 cm.  Entirely submitted for frozen section in cassette AFS. B:  The specimen is received fresh from the O.R. and labeled "Left ureter." It consists of a segment of ureter measuring 0.7 x 0.7 x 0.4 cm. Entirely submitted for frozen section in cassette BFs. C: The specimen is received fresh from the O.R. and labeled "prostate, Bladder.". It consists of a bladder with associated prostate measuring overall 17 x 14 x 4.5. cm. The bladder measures 6.5 x 4 x 3 cm. Opening of the prostate and the bladder anteriorly reveals a pink-tan, fungating mass measuring 3 x 2.2 x 1 cm, located at the mid to left bladder, near the trigone region.  The tumor grossly invades the muscularis propria into the pericystic adipose tissue, and Is 2.5'cm from the black inked surgical margin. There is a green-yellow necrotic ulcerative region measuring 4 x 2 x 0.3 cm adjacent to the mass lesion.  The remainder of the bladder mucosa shows focal erythematous, edematous area.  The wall of the bladder measures 1.1 cm in thickness. The right ureter measures 4 cm in length by 0.5 cm in diameter and appear to be dilated.  The left uretermeasures 2 cm in length by 0.5 cm in diameter.  The prostate measures 5 x 4 x 4 cm. The prostatic urethra measures 3 cm in length by 2 cm in circumference.  The verumontanum measures 1.8 x 0.3 x 0.1 cm. The right vas deferens measures 4.5 cm in length by 0.6 cm in diamter, and the left vas deferens measures 2.5 cm in length by 0.5 cm in diameter.  The right seminal. vesicle measures 3 x 1.5 x 0.7 cm, and the left seminal vesicle measures 3 x 2 x
+
+--- Page 3 ---
+Page 3 of 5 Collectedn Ordered by 0.5 cm. Sectioning of the prostate reveals pink-tan, nodular cut surface. Representative sections are submitted in a total of 24 cassettes. The specimen is received in formalin and labeled "Lymph node of cloquet, left." D It consists of a fragment of yellow-tan tissue measuring 2 x 1.2 x 0.8 cm.  One lymph node measuring 0.s cm in greatest dimension is identified. This lymph node is bisected and the specimen is entirely submitted in one cassette. E:  The specimen is received in formalin and labeled "Obturator lymph node left." It consists of multiple fragments of yellow-tan, soft tissue measuring 6 x 4 x 2 cm in aggregate. Multiple lymph nodes are identified with the largest one measuring 2.8 cm in greatest dimension..  The largest lymph node is bisected and the specimen is entirely submitted in three cassettes. F  The specimen is received in formalin and labeled "Hypogastric lymph node left." It consists of a fragment of yellow-tan, soft tissue measuring 5 x'2 x 0.8 cm. One lymph node is identified measuring 3 cm in greatest dimension.  The lymph noded is bisected and the specimen is entirely submitted in one cassette. G: The specimen is received in formalin and labeled "Presacral lymph node." It consists of a fragment of pink-tan, soft tissue measuring 2 x 1 x 0.5 cm. Two lymph nodes are identified with the largest one measuring o.7 cm in greatest dimension. Entirely submitted in one cassette. H  The specimen is received in formalin and labeled "Left common iliac lymph node." It consists of a fragment of pink-tan, soft tissue measuring 2.2 x i x 0.5 cm. The specimen is entirely submitted in one cassette. I: The specimen is received in formalin and labeled "Right cloquet lymph node." It consists of a fragment of yellow-tan, soft tissue measuring 3 x 2 x i cm. possible lymph nodes are identified with the largest one measuring 1.8 cm in greatest dimension..  The lymph nodes are bisected and the specimen is entirely submitted in one cassette.. J:  The specimen is received in formalin and labeled "Right obturator lymph nodes." It consists of multiple fragments of yellow-tan soft tissue measuring 7 x 5 x 1 cm dimension.  The specimen is entirely submitted in three cassettes. K:  The specimen is received in formalin and labeled "Right external iliac lymph node." It consists of a fragment of yellow-tan soft tissue meaauring 3 x 1.5 x 0.5 cm.  One lymph node is identified measuring 2.5 cm in greatest dimension. The. lymph node is bisected and the specimen is entirely submitted in one cassette. L  The specimen is received in formalin and labeled "Right hypogastric lymph node." It consists of a fragment of yellow-tan soft tissue measuring 2 x 1 x 0.5 cm. The specimen is entirely submitted in one cassette.  The specimen is received in formalin and labeled Right common iliac lymph M node." It consists of a fragment of yellow-tan soft tissue meausring 2 x i x 1 cm.  One lymph node is identified which measures 0.9 cm in greatest dimension. The lymph node is bisected and the specimen is entirely submitted in one cassette. N: The specimen is received in formalin and labeled "Left proximal ureter." It consists of a segment of ureter measuring 1.5 cm in length by 0.5 cm in diameter. Two metallic clips closest to the proximal margin are identified. The proximal margin is submitted in one cassette. O: The specimen is received in formalin and labeled "Right proximal ureter." It consists of a segment of ureter measuring 1.6 cm in length by 0.7 cm in diameter.
+
+--- Page 4 ---
+Page 4 of 5 Collected Ordered Two metaliic clips are located closest to the proximal" margin. The proximal.  margin is submitted in one cassette. SECTIONS : AFS: frozen section, right ureter BFS: frozen section, left ureter C1: right ureter, distal margin C2,3: prostate apex C4 : right vas deferens and seminal vesicle. C5: left vas deferens and seminal vesicle C6-10: mass lesion. C11: left lateral C12 : left dome C13: right dome C14: right lateral cIS: right trigone C16: right ureteral distal margin C17: right distal prostate C18: left distal prostate C19: right midprostate C20 : left midprostate. C21: right midprostate, serially sectioned C22 : left midprostate, serially sectioned. C23 : right proximal prostate C24 : left proximal prostate D: lymph node of Cloquet, left E1: one lymph node, bisected E2,3: possible lymph nodes F: hypogastric lymph node, left g: presacral lymph node H: left common iliac lymph node I: right lymph node of'cloquet J1: one lymph node, bisected J2,3: possible lymph nodes K: right external iliac lymph node L: right hypogastric lymph node M: right common iliac lymph node N: left proximal ureter 0: right proximal ureter MICROSCOPIC DESCRIPTION: A-B: See final microscopic-diagnosis. C: Sections of the fungating seen grossly on the left posterior trigone region of bladder corresponding histologically to a poorly differentiated invasive transitional cell carcinoma, grade 4/4 (cs-10). The neoplastic cells have high N/C ratios with large pleomorphic nuclei and are arranged in solid sheets. The cytoplasm shows clear cell change. There is focal squamous metaplasia present as well as frequent mitosis. A moderate inflammatory response to the tumor is noted. The tumor extends through the muscularis propria. The radial inked resection margins are free of tumor.  No associated transitional cell carcinoma in situ identified. No definitive lymphovascular space invasion is seen. Sections of the prostate show extensive neoplastic process involving the right and left lobes from distal to proximal (c17-20,24). The tumor is characterized predominantly by irregularly shaped and variably sized malignant glands that randomly infiltrate the stroma. A small component of the tumor show malignant gland fusion. The neoplastic cells are medium to large with high nuclear to cytoplasmic ratios, vesicular chromatin and prominent nucleoli. The prostatic
+
+--- Page 5 ---
+Page 5 of 5 capsule is free of tumor. "There are multifocal areas of perineural invasion. No lymphovascular space invasion identified. Bilateral seminal vesicles and vasa deferentia are free of tumor.  Apical margin is free of tumor. In addition to invasive carcinoma, the prostatic parenchyma shows high grade prostatic stratified layers of enlarged cells with large nuclei and prominent nucleoli. D-O: See final microscopic-diagnosis. Signed by: ELECTRONIC SIGNATURE POST-OPERATIVE DIAGNOSIS: Same PRE-OPERATIVE DIAGNOSIS: Bladder TCC ORDERING PHSYCIAN: Ordering Physician:
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diff --git a/output/text/ef84a42e-9cf5-405b-8ca8-0396a6ab419b.txt b/output/text/ef84a42e-9cf5-405b-8ca8-0396a6ab419b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..feeabb91efdc0053280b351fd97ba615d089aa35
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SUPPLEMENTAL REPORT DIAGNOSIS: C BONE FROM MAXILLARY SINUS: MINUTE FRAGMENT OF BONE AND FOCI OF SQUAMOUS CARCINOMA. DIAGNOSIS (A) TUMOR HARD PALATE: INVASIVE WELL-DIFFERENTIATED SQUAMOUS CELL CARCINOMA INVOLVING BONE. (b) MAXILLARY SINUS: FRAGMENTS OF INVASIVE WELL-DIFFERENTIATED SQUAMOUS CELL CARCINOMA. (c) BONE FROM MAXILLARY SINUS: Pending decalcification. (d) TISSUE FROM LATERAL SIDE OF PALATE: salivary gland, no tumor present. (e) MUCOSA RIGHT MAXILLARY SINUS: INVASIVE WELL-DIFFERENTIATED SQUAMOUS CELL CARCINOMA. Respiratory mucosa, no tumor present. PARTIAL' MAXILLECTOMY: INVASIVE WELL-DIFFERENTIATED SQUAMOUS CELL CARCINOMA. GROSS DESCRIPTION of tan soft tissue 2.0 x 1.5 x 0.5 cm. Submitted in toto in Al and A2. (b) TUMOR FROM MAXILLARY SINUS - Mu1t1pTe fragments.  tan soft tissue 1.5 x 1.0 x 0.5 cm in aggregate. Submitted in toto in B.. (c) BONE FROM MAXILLARY SINUS - Mu7tip1e fragments of bone 0.8 x 0.8 x 0.2 cm Page 1 of 2 History Case Pathology Report History Case Pathology File under: Pathology
+
+--- Page 2 ---
+in aggregate. Submitted in toto in c pending for decalcification.. (D) ~TrsSUE FROM LATERAL SIDE OF PALATE - Two fragments of tan soft tissue 0.6 and O.8 cm in greatest dimension._ Submitted in toto in D. (E)  MucosA mAxILLARy sINus - Multiple fragments of tan soft tissue 0.8 x 0.6 x 0.2 cm in aggregate. Submitted in toto in e.. the depth of 2.0 cm with attached three teeth anterior. The specimen is oriented by the surgeon. At the center of the specimen there is an exophytic tan-soft mass 3.0 x 2.8 x 1.2 cm. The mass extends to the base of the specimen.. cm from lateral margin, 0.2 cm from medial margin, 0.5 cm from posterior  The mass is 0.1 margin and 1.3 cm from'anterior margin.. Fragments of bone are noted at base of specimen.. INK cODe: red-medial half of specimen. section coDe: F1, posterior margin en face; F2-F4, tumor with deep margin perpendicular (F4, contains bone fragment pending for decalcification); F5, F6, more tumor; F7, anterior margin en face. Remaining bone fragments' sent to Bone Lab for further processing. SNOMED CODES M-80703 T-11170 T-22000 T-51100 Page 2 of 2 History Case Pathology Report History Case Pathology File under: Pathology
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diff --git a/output/text/efaf966d-be3f-4ee4-83d8-db15abfabed1.txt b/output/text/efaf966d-be3f-4ee4-83d8-db15abfabed1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e9e74783428437cd991ce05c57bf4bfd2fafb855
--- /dev/null
+++ b/output/text/efaf966d-be3f-4ee4-83d8-db15abfabed1.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+Page I ot 4 UUID:8C263A39-C697-4BBF-9444-ECBF56443CAA Redacted Ice -0-3 8o70f3 CQCE Ste path Dept Phone. sial ceiv Encounter Description: Male DOB: MRN J8I13 I13 #: Department: Order Surgical Pathology Request. Entry Date Result Narrative FINAL DIAGNOSIS A) Tongue, glossotonsillar mass, biopsy: Invasive squamous cell carcinoma, moderately differentiated (see comments) B) Lymph nodes, right neck, selective neck dissection:. - Metastatic moderate to poorly differentiated squamous cell carcinoma (3.5 cm in greatest dimension), see comments.  Thirty one lymph nodes, negative for metastatic carcinoma (0/31). C) Tongue mass, right base, excision:. Salivary gland parenchyma admixed with skeletal muscle, negative for malignancy. COMMENT The frozen section slides from specimen A were reviewed and the carcinoma is not well represented on those slides The large tumor mass in the right neck does not contain any lymphoid tissue within it, and may represent either a soft tissue tumor deposit or (more likely) a lymph node which has been completely replaced by tumor.  If this is a replaced lymph node, there is extranodal extension of tumor into the surrounding soft tissue.. Immunohistochemical preparations, with appropriately staining controls were performed on a representative section of. tumor from specimen B and show the following results: Tumor cells are strongly and diffusely positive for pl6 and show no circumferential membranous staining for Egrr. Hpv studies have been ordered and the results will be issued in a separate report. CLINICAL HISTORY -year-old male with recently diagnosed metastatic squamous cell carcinoma of the neck with a glossotonsillar mass.. GROSS DESCRIPTION A)Received fresh for intraoperative consultation labeled with patient's name and medical record number designated "glossotonsillar mass," is one fragment of pink- tan soft tissue measuring 1.6 x 1.3 x 0.8 cm. The specimen is inked and bisected and submitted entirely for frozen section consultation. The frozen section. remnant is submitted entirely in cassette (FsAl).. :iteria lL1129/13]
+
+--- Page 2 ---
+Page 2 ot 4 B) Received fresh for tissue banking, labeled with the patient's name and medical. record number, and designated "right selective neck dissection, stitch marks: Level 2," is a 38 g irregular tan-yellow fibroadipose tissue, 5.5 x 3 x 2.5 cm. A well-circumscribed 3.5 x 2.4 x 2.2 cm brown-red nodule is designated "Level 2," with a previously placed surgical stitch. The remainder of the tissue is. irregular brown-red nodular fibroadipose tissue. Serial sectioning through the large nodule reveals tan-white homogeneous indurated cut surface. Lymph node dissection is performed on the remainder of the unremarkable nodular fibroadipose tissue. Sections are submitted as follows: (B1-B2) Representative sections through large indurated mass. (B3) Five candidate lymph nodes. (B4) Four candidate lymph nodes. (B5) Four candidate lymph nodes (B6) Four candidate lymph nodes (87-b16) Remaining fibroadipose soft tissue other than large indurated mass, submitted entirely C) In formalin labeled right base tongue," is a cauterized. irregular rubbery skeleta.  muscle 1.5 x 1.2 x 0.6 cm. Tissue is inked black and. is not oriented. Tissue is sectioned and submitted in its entirety as (c1). INTRAOPERATIVE DIAGNOSIS FsAl: Glossotonsillar mass: Benign. Intra-Operative Diagnosis Reviewed and Interpreted By:. 'I certify that (l) all services on this form were rendered and are hereby approved for billing, (2) all specimens/slides have been examined / reviewed, (3) the medical record has been documented for these services, and (4) the rendering of the services and the documentation in the medical record are in accordance with guidelines.' Final Diagnosis Reviewed and Interpreted by:. ELECTRONICALLY SIGNED Pathologist Date: Some tests used in this case were developed in and their performance characteristics determined by the. . The procedures and reagents have been validated. by evaluation of both negative and positive controls. This testing has not been
+
+--- Page 3 ---
+Page 3 ot 4 cleared or approved by the U.S. Food and Drug Administration (FdA). The FDA has determined that such clearance or approval is not necessary. Test results are used for clinical purposes. They should not be regarded as investigational or for research. The is accredited by the College of American Pathologists and is certified under the Clinical Laboratory Improvement Amendments of 19ss (cLIA-88) as qualified to perform high complexity clinical laboratory testing. "I certify that (1) all services on this form were rendered and are hereby approved for billing, (2) all specimens/slides have been examined / reviewed, (3) the medical record has been documented for these services, and (4) the rendering of the services and the documentation in the medical record are in accordance with guidelines." Lab and Collection Surgical Pathology Request on Specimen Information Specimen # Collection Date Received Date and Time Resultina Agency Reviewed by List Surgical Pathology Request Ordering Physician Provider Not In System Result Information Status Provider Status Final result Reviewed Surgery Report Lab Printout Open Hard Copy Result Report. - Surgical Pathology Reguest) Order Report View Order Information Dept Phone: Hospital Encounter Encounter Description: Male DOB: MRN : #: Department: Lab Collection Information Lab IDs Collectinn Nate Snecimen #
+
+--- Page 4 ---
+rage 4 or 4 Surgical Patholoav Request Authorizing: Date and Time: Lab Department: Electronically Signed By: Order Information Order Date/Time Release Date/Time Start Date/Time End Date/Time Comments Ordered by an unspecified provider Order Details  Frequency Duration Priority Order Class ONCE 1 occurrence Routine  Normal Provider Information Ordering User Ordering Provider Authorizing Provider Results Incoming Attending Provider(s) Admitting Provider Collection Information Collection Date Resuiting Agency Order Report View Order Information There are no specimens. Reprint Requisitions Surgical Pathology Request  on.
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diff --git a/output/text/efd4ad96-b4ac-4bff-ba85-f2cbab4083e9.txt b/output/text/efd4ad96-b4ac-4bff-ba85-f2cbab4083e9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7fa6a4626ac158bbe74cd2ba03d14ec436118bb3
--- /dev/null
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@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:4E013D66-E9BD-49D1-8CA5-CABFE070D78E Redacted rcDo 3 8120f3 Sit Badsu xss C67.9 Surgical Pathology Report QpJ 5ho/3 DATE OBTAINED: LOCATION: DATE RECEIVED SUBMITTING MD: DATe rEporTED: cC: DIAGNOSIS 1. Left distal. ureter, biopsy: benign urothelium and wall; no tumor. 2. Lymph noDe, Left pelvic, exTensiOn: One Out Of eleven lymph noDes pOsitIve fOr MEtASTaTIC hIgh GrADe UrOTheLiAl CARciNoMA (1/11). 3. right Distal ureter, biopsy: benign urothelium and wall; no tumor. 4. Lymph node, right pelvic, eXcision: two out Of fifteen lymph nodes positive fOr Metastatic hIgh GrAde UrotheliAl CArcinOma (2/15). 5. blADDer And prOstate, raDical CystOprOstatectOmy: invasive UrOthelial CarcinomA Histologic type: Urothelial carcinoma Histologic grade: High grade/poorly differentiated Tumor size: 8 cm *Tumor site:  Bladder wall and prostatic urethra (with further invasion into prostate). Tumor multicentricity: Multicentric Microscopic tumor extension:. Tumor invades into perivesical fat and prostatic stroma (apex). Extravesical extension:. Present (tumor invades into prostatic stroma at the apex through prostatic urethra). Vascular invasion: Possible present Perineural invasion: Present Associated epithelial lesions: Non-invasive high grade urothelial carcinoma and carcinoma in situ. Margins: Negative urethral, left and right ureter and radial margins. Prostate & seminal vesicles: Prostate involved by tumor; negative seminal vesicles Lymph nodes: Three out of thirty-one lymph nodes positive (3/31), including specimens #3, #4 & #5 cTNM: (given by clinician) Clinical stage III pTNM: pT4a, pN2 AJCC STAGE (2010): Stage IV 6. Left ureter, true margin, EXcision: urothelium with reactive Changes; nO tumOr. 7. Right Ureter, True margin, EXciSiOn: BeNIgn urOtheLium AnD wall; NO TumOR. ***Electronically Signed Out*** COMMENT 88305x4, 88307x2, 88309, 88331x2 Page 1 of 3
+
+--- Page 2 ---
+Surgical Pathology Report. Clinical Diagnosis and History: Bladder ca Stage 3 Tissue(s) Submitted: 1: LEFT DISTAL URETER 2: LEFT PELVIC LYMPH NODES 3: RIGHT DISTAL URETER 4: RIGHT PELVIC LYMPH NODES 5: BLADDER AND PROSTATE 6: LEFT URETER TRUE MARGIN 7: RIGHT URETER TRUE MARGIN Gross Description: Specimen #1 is received fresh for intraoperative consultation labeled left distal ureter and consists of a 0.4 x 0.2 cm tubular tissue  which is submitted in toto for frozen section diagnosis labeled FS1A. The frozen residue is submitted in the corresponding cassette. Specimen #2 is received in formalin labeled left pelvic lymph nodes and consists of a 5.0 x 3.5 x 2.0 cm aggregate of fat which is palpated to reveal multiple nodes ranging from 0.1 cm to 3.0 cm in greatest dimension. The nodes are entirely submitted as follows: 2A: three possibie nodes 28: two possible nodes 2C-2F: each cassette containing one bisected node 2G-2I: one trisected node 2J-2M: one serially sectioned node 2N: 1 bisected node  Specimen #3 is received fresh for intraoperative consultation labeled right distal ureter and consists of a 0.6 x 0.4 cm tubular tissue  which is submitted in toto for frozen section diagnosis labeled FS3A. The frozen residue is submitted in the corresponding cassette. Specimen #4 is received in formalin labeled right pelvic lymph nodes and consists of a 5.0 x 3.0 x 2.0 cm aggregate of fat which is  palpated to reveal multiple possible nodes ranging from 0.3 cm to 3.5 cm in greatest dimension. The nodes are entirely submitted as follows: 4A: four possible lobes 4B-4C: each cassette containing two nodes 4D-4G:  each cassette containing one bisected node 4H-4I: one bisected node. 4J-4K: one serially sectioned node 4L-4N:  one serially sectioned node Specimen #5 is received fresh labeled bladder and prostate and consists of a 12.5 x 11.0 x 5.0 cm bladder with attached 5.0 x 4.5 x 4.5 cm prostate. Extending from the prostatic urethra is a 35.0 x 0.7 cm catheter. Partially surfacing the posterior aspect is a 14.0 x 10.0 cm area of smooth peritoneum. Attached to the prostate are right and left vas deferens averaging 5.0 x 0.5 cm. The left seminal vesicle measures 4.5 x 2.0 x 1.0 cm and the right seminal vesicle 4.5 x 2.0 x 0.5 cm. The right half of the specimen is inked blue, the left half is inked black and the specimen is opened with a Y-shaped incision along the anterior aspect to reveal an 8.0 x 6.0 x 1.5 cm focally soft and necrotic papillary lesion involving the dome, posterior, anterior and left lateral wall of the bladder. Noted on the prostate, at the bladder base, are several papillary growths grossly not contiguous with the main mass measuring 1.0 cm in greatest dimension. Further sectioning reveals the mass effacing an area of muscle in the left lateral wall, focally possibly invading into the adipose tissue, 0.3 cm from the posterior ink. The tumor does not grossly appear to involve the ureter. Serial  sectioning of the prostate reveals a 1.5 x 0.6 cm ill defined tan lesion in the right apex towards the posterior aspect, grossly abutting the inked capsule. Palpated are five possible nodes ranging from 0.1 cm to 1.5 cm in greatest dimension. Note that approximately 90% of the prostate is submitted. Representative sections are submitted as follows: 5A: possible urethral margin en face  5B-5C: perpendicular sections of right apical prostatic margin. 5D-5E: perpendicular sections of left apical prostatic margin. 5F-5G: bisected section of trigone with papillary growths near bladder base of prostate. 5H: trigone with prostate to include papillary growths near prostatic bladder base 51: right ureteral orifice 5J: Ieft ureteral orifice. 5K-5N: tumor to closest ink from left lateral wall (contiguous sections) 50: tumor to left lateral wall with possibly involved fat. 5P: tumor to possibly involved vessel from left lateral wall. Page 2 of 3
+
+--- Page 3 ---
+Surgical Pathology Report 5Q-5T:  tumor to closest invasion to posterior ink. 5U-5V: tumor in dome 5W-5Z: tumor in anterior wall 5AA-5CC: right lateral wall. 5DD-5ZZ: right prostate 5AAA-5WV: left prostate 5WWwW-5XXX: bisected section of right prostate with seminal vesicle 5YYY-5ZZZ: left prostate with seminal vesicle 5AAAA: right and left vas deferens margin. 5BBBB: three possible nodes 5CCCC: one bisected node 5DDDD: one bisected node Specimen #6 is received in formalin labeled left ureter-true margin and consists of a 1.5 x 0.6 cm tubular tissue with an attached suture on one end. The specimen is entirely submitted as follows: 6A: sutured end 68: middle cross sections 6C: end opposing suture Specimen #7 is received in formalin labeled right ureter-true margin and consists of a 2.3 x 0.4 cm tubular tissue sutured on one end. The specimen is entirely submitted as follows: 7A: sutured end 78: middle cross sections 7C: end opposing suture Intraoperative Consult Diagnosis. 1A/FSDX: URETER NEGATIVE FOR TUMOR. 3A/GDX/FSDX: URETER WITH ACUTE INFLAMMATION AND REACTIVE CHANGES; NO TUMOR. Page 3 of 3 END OF REPORT
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diff --git a/output/text/eff9f41f-764f-4086-8ed8-89665938920d.txt b/output/text/eff9f41f-764f-4086-8ed8-89665938920d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f418414cbfbcf1b22988dc050fc8a2e2587e5cf1
--- /dev/null
+++ b/output/text/eff9f41f-764f-4086-8ed8-89665938920d.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TCGA #: Sample ID #: Diagnosis: Resected section of colon (left hemicolon) with two colon carcinomas characterized histologically as colorectal adenocarcinoma of similarly moderate differentiation, one. located at a distance of 3.5 cm from the resection margin, with a diameter of 3.5 cm at the. widest point, and the other located 18 cm from the same resection margin, and measuring 3.3 cm at the widest point, one at the base of a tubulovillous adenoma with severe epithelial dysplasia (synonymous: profound intraepithelial neoplasia), and the other clearly at the base of a tubular adenoma with severe epithelial dysplasia (synonymous: profound intraepithelial neoplasia). Invasive spread of the tumor to the layers of the muscularis propria. Mucous membrane of the colon with a tubulovillous adenoma of the colon mucosa with severe epithelial dysplasia (synonym: profound intraepithelial neoplasia) and two tubular adenomas of the colon mucosa, with moderate epithelial dysplasia (synonym: mild. intraepithelial neoplasia).. Tumor-free oral and aboral resection margin. 36 local lymph nodes are tumor-free with uncharacteristically reactive changes. Stage of tumor of both colon carcinomas: pT2 pN0 (0/36) L0 V0; G2 R0. ICD-0-3 8140/3 adino caiciioma, N0S Sits: sigmnd cson (pw cacF) C18.7 w 3/30/1 UUID:51A15A40-E61 Redacted
\ No newline at end of file
diff --git a/output/text/f056e2f7-d6e3-4692-b812-dbb2fcc46de7.txt b/output/text/f056e2f7-d6e3-4692-b812-dbb2fcc46de7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fe6b3d8e83683d3f24abdaf63e209ad806b81b01
--- /dev/null
+++ b/output/text/f056e2f7-d6e3-4692-b812-dbb2fcc46de7.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+UUID:FC0B979B-314A-487D-9BBB-E6F8BE3C4E62 TCGA-KM-A7Q8-018-PR Redacted Patient Results Page 1 of 4 Admit Date: Gender: Male Birth Date: Age: Attending. Admit Protocol: Location: Surgical Pathology [OrderID: Final Results  Surgical Pathology Final CASE NUMBER: ICD-o-3 DIAGNOSIS: Cercuona,renal cIl 1. Lymph nodes, periaortic, resection: Metastatic Renal cell carcinoma in lymph nodes; (2/40). Chromsphsbe Type 8317|3 2. Kidney, left, nephrectomy: Renal parenchyma with chronic interstitial nephritis; no tumor seen. Vascular and ureteral margins are free of tumor. QJ 9Q4113 3. Left kidney tumor mass, resection: Renal cell carcinoma, chromophobe type with diffuse spindle cell (sarcomatoid) component. Tumor permeates the capsule. Extensive vascular invasion present. See Note. 4. Lymph nodes, hilar, resection: One of ten lymph nodes involved by tumor (1/10) NOTE: Metastatic involvement by tumor is seen diffusely in the lymphatics present in the fibroadipose tissue. Surgical Pathology Cancer Case Summary KIDNEY: Nephrectomy Procedure: Radical nephrectomy Specimen Laterality: Left Tumor Size: Greatest dimension: 20 cm Tumor Focality: unifocal Macroscopic Extent of Tumor. Tumor extension into perinephric tissues Histologic Type: Chromophobe renal cell carcinoma Sarcomatoid Features: Present Specify percentage of sarcomatoid element: _.50_ % Tumor Necrosis: Present Histologic Grade: Not applicable Microscopic Tumor Extension: Tumor extension into perinephric tissue (beyond renal capsule) Margins: vascular and ureteral margins uninvolved by carcinoma Lymph-Vascular Invasion (excluding renal vein and its muscle containing segmental branches and inferior vena cava): Present Pathologic Staging (pTNM) Confidential Patient Intormation. Unauthorized disclosure is prohibited by the Federal Privacy Act of 1974. JobID: Requested By:  Do not file in Medical Record
+
+--- Page 2 ---
+Patient Results Page 2 of 4 Admit Protocol: Gender: Male Birth Date: Age: . Admit Protocol: Admit Protocol: Location: Surgical Pathology [OrderID: Final Results pT3: Tumor extends into major veins or perinephric tissues but not into the ipsilateral adrenal gland and not beyond Gerota's fascia pN1: Metastasis in regional lymph node(s) Number of Lymph Nodes Examined : 50 Number of Lymph Nodes Involved : 3 Distant Metastasis (pM): Not applicable Pathologic Findings in Nonneoplastic Kidney: chronic interstitial  nephritis Immunoperoxidase and in-situ hybridization tests performed here and used for diagnosis were developed and their performance characteristics determined by the They have not been cleared or approved by the U.S. Food and Drug Administration. The FDA has also determined that such clearance or approval is not necessary. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLlA) as qualified to perform high complexity clinical laboratory testing.. CLINICAL INFORMATION: Brief Clinical History: Large left renal mass Specimen Taken For Protocol: 01 - Yes Allocate Order to Protocol: PROCEDURE: Pre-Operative Diagnosis: Renal cell carcinoma Post-Operatlve Diagnosis: same Operative Findings: Large renal mass, kidney removed SPECIMENS SUBMITTED: 1. PERIAORTIC LYMPH NODE 2. KIDNEY, LEFT 3. TUMOR, Left kidney 4. HILAR LYMPH NODE GROss DEsCRIPTiON: Received are 3 specimens fresh in containers labeled with the patient's name, medical record number, and further specified as follows: 1. "Periaortic lymph nodes". The specimen consists of tan-yellow fragments of fatty-appearing soft tissue measuring approximately 7 cm x 6.5 cm x 2 cm. The specimen is sectioned and entirely submitted in white cassettes 1A-1P. 1 C is 1 lymph node bisected. 1E is 1 lymph node oisected. 2. "Left kidney". The specimen consists of a kidney measuring 15.5 cm x 6.5 cm x 4.5 cm. The resection margin is 14 x 6 cm. Attached fatty tissue is 26 x.19 x 2 cm. Gross photographs are taken. Approximately 3 x 2 x 0.5 cm of tissue is procured for Remainder of the specimen is placed into formalin and submitted to Confidential Patient Information. Unautharized disclosure is prohibited by the Federal Privacy Act ot 1974. JobID: Requested By: Do not file in Medical Record
+
+--- Page 3 ---
+Patient Results Page 3 of 4 Admit Protocol: Gender: Male Birth Date: Age: Admit Protocol: Admit Protocol: Location: Surgical Pathology [OrderID: Final Results pathology for permanent processing. Procurement was performed by and on at The remaining specimen is submitted to Pathology for permanent processing. The specimen is received in Surgical Pathology and matches the above description. The fatty tissue is. sealed off and structure resembling the ureter is identified. The pelvis is grossly distorted (this is where the tumor was at the hilum of the kidney). Representative sections are placed as follows: 2A - possible ureter and vascular margins. 2B - representative sections of kidney parenchyma from the pelvis. 2C- representative sections of kidney parenchyma from the cortex. 2D-2F: possible lymph nodes. 2G-2P: Additional sections of specimen #2 3. "Left kidney tumor".The specimen measures overall 20 x 15.5 x 12 cm. The specimen weighs approximately 1,600 grams. The external surface of the mass was inked in black prior to cutting it open for procurement. Cut surface is variegated and appears to. be hemorrhagic and necrotic and cystic. Aporoximately 3 cm x 2 cm. x 1 cm of tissue was procured for by. and Dr. on at Specimen is received in surgical pathology and matches the above description.. Reoresentative sections of the tumor are placed in white cassettes. . Additional sections of tumor are placed in green cassettes 4. "Hilar lymph nodes". The specimen consists of tan-yellow fatty-appearing tissue measuring approximately 4.5 cm x 3 cm x 1 cm. The specimon i. sectioned and entirely submitted in white cassettes -4I. 4A is 1 lymph node bisected. 4B is 1 lymph node bisected.. Gross Description dictated by . on  Additional Gross Description dictated by on  Additional Gross Description dictated by  on Additional Gross Description dictated by on No consultants Accessioned: Final Report Signed Out: <Resident Sianature> M.D. Clinical Resident. <Sign Out Dr. Signature> ATTENDING STAFF PATHOLOGIST Contidential Patient Infonnation. Unauthorized disclosure is prohibited by the Federal Privacy Act of 1974. JobID: Requested By: Do not file in Medical Record
+
+--- Page 4 ---
+Patient Results Page 4 of 4 Admit Protocol: Gender: Male Birth Date: Age: ' Admit Protocol: Admit Protocol: Location: Surgical Pathology [OrderID: Final Results Date Report Signed: Contidential Patient Infonnation. Unautharized disclosure is prohibited by the Federal Privacy Act of 1974. JobID: Requested By: Do not file in Medical Record.
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diff --git a/output/text/f06fc60b-0ac0-4a6b-ae97-d319efad980b.txt b/output/text/f06fc60b-0ac0-4a6b-ae97-d319efad980b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e475b5270308a382823509ecf27fb856741122be
--- /dev/null
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+
+--- Page 1 ---
+Page 1 of 4 UUID:81FC9A66-472B-488F-BE20-BE2E74E5A0D6 tcgA-SS-A7h0-01A-PR Redacted Final Pathologic Diagnosis A) RIGHT COLON AND DISTAL ILEUM (PARTIAL COLECTOMY): Invasive colonic adenocarcinoma (See synoptic report). B) iNFERIOR MARGIN (PARTIAL COLECTOMY): Fibromuscular tissue with atrophy, necrosis, granulation tissue and chronic inflammation. Negative for malignancy.. C) POSTERIOR MARGIN (PARTIAL COLECTOMY): Organizing fat necrosis with inflammation.. Negative for malignancy. D) LATERAL MARGIN (PARTIAL COLECTOMY): Fibromuscular tissue with atrophy and chronic inflammation. Negative for malignancy. E) SUPERIOR MARGIN (PARTIAL COLECTOMY): Organizing fat necrosis with inflammation. Negative for malignancy. NOTE: This case was revlewed in conjunctlon with one or more attending pathologists in this department who concur(s) with the above diagnosis. I attest I have personally reviewed the specimen/slides and agree with the above findings. IcD0.3 Sit Cecun CJ8.0 Resident: 1> 9/2s/3 Synoptic Report A: COLON/RECTUM, RESECTION - SPECIMEN: Terminal ileum Cecum Appendix Ascending colon PROCEDURE: Right hemicolectomy
+
+--- Page 2 ---
+Page 2 of 4 SurgicalFinaiR ebor Specimen length (if applicable): Specify: 35.3 cm TUMOR SITe: Cecum TUMOR SIZE: Greatest dimension: 9.5 cm *Additional dimensions: 8.5 x 8.0 cm MACROSCOPIC TUMOR PERFORATION: Present HISTOLOGIC TYPE: Adenocarcinoma HISTOLOGIC GRADE: High-grade (poorly differentiated to undifferentiated) HISTOLOGIC FEATURES SUGGESTIVE OF MICROSATELLITE INSTABILITY:  Intratumoral Lymphocytic Response (tumor-infiltrating lymphocytes)  Mild to moderate (0-2 per high-powered (x400) field) Peritumor Lymphocytic Response (Crohn-like response) Mild to moderate  MICROSCOPIC TUMOR EXTENSION: Tumor penetrates to the surface of the visceral peritoneum (serosa) and directily invades adjacent structures (specify:) soft tissue MARGINS:  Proximal Margin  Uninvolved by invasive carcinoma Distal Margin Uninvolved by invasive carcinoma. Circumferential (Radial) or Mesenteric Margin Involved by invasive carcinoma (tumor present 0-1 mm from margin) TREATMENT EFFECT: Not known LYMPH-VASCULAR INVASION: Present PERINEURAL INVASION: Not identified TUMOR DEPOSITS (discontinuous extramural extension): Not identified TYPE OF POLYP IN WHICH INVASIVE CARCINOMA AROSE: Tubular adenoma PATHOLOGIC STAGING:E PRIMARY TUMOR (pT) pT4a: Tumor penetrates the visceral peritoneum REGIONAL LYMPH NODES (pN) pN0: No regional iymph node metastasis Specify Number examined: 25 Number involved: 0 DISTANT METASTASIS (pMX) Not applicable COMMENT(S):: Focal squamous differentiation in the tumor is noted (section A4).
+
+--- Page 3 ---
+Page 3 of 4 Special Procedures IMMUNOHISTOCHEMICAL STAINS: Stains performed at Representative tissue present in all sections examined. Positive and negative controls react appropriately. Interpreted by: Performed on block(s): A4 CK7: Negative. CK20: Patchy positivity in a small subset of tumor cells. This test was developed and its performance characteristics determinsd by has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or it approval is not necessary. This test is used for clinical purposes. il should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLiA-88) as qualified to porform high complexity ciinical laboratory testing. Clinical History Not provided. Pre/Post-operative Diagnosis Colon cancer. Gross Anatomic Description Specimens received in five containers. Speclmen A: Designated "right colon distal ileum' is received in formalin labeled with the patient's name and "right colon distal ileum". Specimen consists of a portion of ileum with attached right colon which measures a total of 35.3 cm in length. The small intestine measures 17.2 cm in length x 3.5 cm in cross sectional diameter. The colon measures 18.1 cm in length and the cross sectional diameter ranges from 5.6 cm distally to 10.2 cm surrounding an enlarged area with focal puckering of the serosal surface. Attached to the colon is a portion of muscle and connective tissue located posteriorly which measures 12.5 x 6.3 x 5.1 cm. The remainder of the serosal surface of both the ileum and right colon are smooth, tan/pink and unremarkable. Attached pericolic fibroadipose tissue Is present. This area of puckering measures 9.5 cm from the colonic resection margin. The area composed of the muscle and connective tissue is inked green. The ileal wall measures 0.2 cm in thickness and the mucosal surface of the ileum with grossly unremarkable. Grossly adjacent to the ileal cecal valve is a Iarge variegated polypoid exophytic pink to green co!ored bosselated mass measuring 9.5 x 8.0 cm and extends to a depth of 8.5 cm. Focally the mass extends to the inked green mmuscle connective tissue resection margin. The remainder of the colonic mucosa is grossly unremarkable and free of additional polyps or diverticuli. The average wall thickness of the colon measures 0.2 cm to 0.3 cm. Gross photographs are taken. Multiple lymph nodes are identified ranging from 0.2 cm up to 3.1 cm in greatest dimension. The appendix is identified upon cross sectloning of the muscle and soft tissue. The appendix is totally encased within the soft tissue making a measurement of length not possible. The cross-sectional dlameter averages 0.6 cm with an intact lumen that is 0.2 cm. The tumor does appear grossly to involve the appendix. Gross photographs are taken. Section code: A1 -- colon resection margin; A2 - ileal resection margin; A3 -- additional representative section of unremarkable colon and ileum; A4-A7 -- representative sections tumor; A8-A10 -- sections of tumor with deepest muscle and soft issue invasion extending to the inked margin; A11 -- three
+
+--- Page 4 ---
+Page 4 0f 4 possible lymph nodes; A12 - three possible lymph nodes; A13 -- three possible lymph nodes; A14 -- four possible lymph nodes; A15 -- three possible lymph nodes; A16 -- two possible lymph nodes; A17 --- one possible lymph node; A18 -- one possible lymph node; A19 -- representative sections of appendix. Specimen B: Designated "inferior margin' is received in formalin labeled with the patient's name and "inferior margin". Specimen consists of two fragments of soft tan/yellow friable fibroadipose connective tissue measuring 4.4 x 3.5 x 2.0 cm and 3.5 x 3.8 x 1.8 cm.  Each specimen is entirely inked blue. Cut surface of each piece reveals white firm fibrous tissue admixed with tan/yellow fibroadipose tissue. Representative sections ot the heavily fibrous areas are submitted in casettes B1-B8. Section code: B1--B8 -- entire specimen. Specimen C; Designated "posterior margin' is received in formalin labeled with the patient's name and "posterior margin". Specimen consists ot two smak fragments of soft tan/yellow bosselated fibroadipose connective tissue each measuring 0.4 x 0.4 x 0.2 cm. The specimens are both entirely inked blue and bisected and submitted in one cassette. Section code:  C1 - entire specimen. Specimen D: Designated "lateral margin' is received in formalin labeled with the patient's name and "lateral margin". Specimen consists of a single portion of soft tan/yellow bosselated fibroadipose connective tissue measuring 2.1 x 2.0 x 1.0 cm. The specimen is entlrely Inked blue. Cut surface reveals predominantly yelow tan bosselated fibroadipose tissue with focal white fibrous streaks. Section code: D1 -- entire specimen bisected. Speclmen E: Designated "superior margin' is received in formalin labeled with the patient's name and "superior margin'. Specimen consists of two small fragments of soft tan/yellow bosselated fibroadipose connective tissue measuring 1.5 x 1.0 x 0.5 cm and 2.5 x 0.5 x 0.5 cm. Each specimen is both entirely inked blue and bisected. Cut surface reveals predominantly yellow tan bosselated. fibroadipose tissue with focal white fibrous streaks. Section code:  E1-E2 -- one specimen each, bisected, entire specimen. Pur TSS, Sqanour cU difuntahin L1% OCR hJ 9/g1L3 -.-
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diff --git a/output/text/f072b279-5cd2-4b63-8bfa-98433677985d.txt b/output/text/f072b279-5cd2-4b63-8bfa-98433677985d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..819a81e31f3c1afb39ca0a3fcc024b461cf2183e
--- /dev/null
+++ b/output/text/f072b279-5cd2-4b63-8bfa-98433677985d.txt
@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+UUID:9F88F244-C30A-409F-BA44-94BEA01771160 TCGA-FD-A3S0-01A-PR Redacted Case#: Sample III Gender: Male DOB: Race: Report Date: Icp:o-3 Pathology Report: carcinomg,wn4heia1, NOs 8120/3 Surgical Pathology Report Site: blgddr,wal, 1a4rg1 FINAL PATHOLOGIC DIAGNOSIS C67.z A. Right pelvic lymph node; dissection: - Six lymph nodes, no tumor (0/6). y.g-iZ R B. Left pelvic lymph node; dissection: - One lymph node, positive for metastatic urothelial carcinoma (1/1) - Lymph nodal tumor focus measures 1.8 cm in greatest dimension. - Extranodal tumor extension present. C. Left pelvic lymph node, dissection: - Nine lymph nodes, no tumor (0/9). D. Urinary bladder, prostate, seminal vesicles and vas deferens;. cystoprostatectomy: - Invasive urothelial carcinoma of the bladder, see pathologic parameters. - Prostate with high grade prostatic intraepithelial neoplasia. - One perivesical lymph node, no tumor (0/1). Urothelial Carcinoma Pathologic Parameters 1. Tumor type: Invasive urothelial carcinoma. 2. Grade of tumor: High grade.. 3. Depth of invasion: Extravesicular soft tissue.. 4. Tumor distribution: Solitary, left lateral bladder wall. 5. Ureteral margins: Negative for tumor.. 6. Distal urethral margin: Negative for tumor. 7. Soft tissue margin or serosa: Negative for tumor. 8. Lymph nodes: Positive for tumor (1/17). 9. pTNM: pT3a,N1,MX. Effective  his Checklist utilizes th. edition TNM staging
+
+--- Page 2 ---
+system for Bladder of the American Joint Committee on Cancer (AJCC) and the. International Union Against Cancer (UICC). xx [] MD Interpretation performed by the Attending Pathologist and reviewed with the Resident/Fellow, [l], MB, PhD Electronically Signed Out by [] MD Clinical History: The patient is a  year-old male with invasive urothelial carcinoma, high grade. undergoing cystoprostatectomy. Specimens Received: A: Right pelvic lymph node B: Left pelvic lymph node. C: Left pelvic lypmh node. D: Bladder, prostate, seminal vesicle, vas deferens Gross Description: The specimens are received in four containers each labeled with the patient's name and medical record number. A. The first container is additionally identified as, "right pelvic lymph node". Received fresh and placed in formalin is a 5.5 x 5.5 x 1.5 cm aggregate of yellow-tan lobulated adipose tissue. The specimen is dissected for lymph nodes and 7 are found measuring 0.3-4.5 cm in greatest dimension and are submitted as follows: A1: 3 lymph node candidates A2-A4: 1 bisected lymph node in each cassette A5-A6: 1 lymph node, sectioned B. The second container is additionally identified as, "left pelvic lymph node". Received fresh for intraoperative consult is a 3.5 x 2.4 x 1.6 cm yellow-tan tissue fragment which is bisected to reveal a 2.2 cm white-tan lymph. node candidate. A representative section is frozen and called "metastatic carcinoma" by Dr. [] The frozen remnant is submitted as B1 FS and the remaining lymph node candidate is submitted as B2-B4. C. The third container is additionally identified as, "left pelvic lymph node" Received fresh and placed in formalin is a 10.5 x 5.5 x 1.5 cm aggregate of
+
+--- Page 3 ---
+yellow-tan lobulated adipose tissue. The specimen is dissected for lymph node candidates. Sections are submitted as follows: C1: 5 lymph node candidates C2: 2 lymph node candidates C3: 1 lymph node candidate, bisected C4: 1 lymph node candidate C5: 1 lymph node candidate C6-7: 1 lymph node, sectioned D. The fourth container is additionally identified as, "bladder, prostate, seminal vesicles and vas deferens".. Received fresh and placed in formalin is a 393.7 g, 16.5 x 15.5 x 4.5 cm cystoprostatectomy specimen consisting of a 7 x 6 x 3.5 cm bladder with attached mesenteric fat and a 4.3 x 4 x 3 cm prostate. The right seminal vesicles measure 4.2 x 1.7 x 0.9 cm and right vas deferens measures 9.5 cm in length by 0.2-0.5 cm in diameter. The left seminal vesicles measures 4.5 x 1.6 x 0.8 cm and left vas deferens measures 10.5 cm in length by 0.2-0.5 cm in diameter. The right ureteral stump measures 1.6 cm in length by 0.6 cm in diameter, the left measures 2 cm in length and 0.6 cm in diameter, and both demonstrate intact, patent lumens to the trigone. The right half of the prostate is inked blue and the left half is inked black. The soft tissue surrounding the bladder is inked black. The bladder and prostate are opened anteriorly along the urethra. The prostate is surrounded by a thin intact membranous capsule and sectioning demonstrates rubbery, pink-tan, peri-urethral nodularity with no discrete masses or indurations. Approximately 50% of the gland is submitted.. The opened bladder reveals a 2.8 x 2.7 cm indurated, tan-yellow shaggy ulcerated mass with a hyperemic rim in the left lateral wall which partially extends to the anterior, posterior, and trigone and involving the left ureter orifice. The ulceration is 5 cm from the distal urethral margin and 0.7 cm from the prostate base. On cut section, the mass extends to the serosa, possibly the  peri-vesicular adipose tissue to a depth of 1.1 cm and is 0.2 cm from the deep  margin. The surrounding bladder mucosa is tan-pink to red and edematous with a uniform 0.9 cm wall thickness. Gross photographs are taken. Representative sections are submitted as follows: D1: Left ureter margin D2: Right ureter margin D3: Distal urethral margin D4: Prostatic apical margin D5-D8: Representative right prostate D9-D12 Representative left prostate
+
+--- Page 4 ---
+D13: Right seminal vesicles. D14: Left seminal vesicles. D15: Bladder mass and proximal prostate D16-D17: Bladder mass, deepest section, and closest approach to soft tissue resection margin D18-D21: Bladder mass and surrounding grossly uninvolved mucosa D22: Uninvolved posterior to right-lateral bladder wall D23: Uninvolved bladder dome D24: Uninvolved anterior bladder wall with possible lymph node D25-D26: Distal ureter margin xx [], M.D. Intraoperative Consult Diagnosis: B1 FS: Metastatic carcinoma per Dr.[]
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diff --git a/output/text/f0821fb7-e99c-47f7-b0ac-075f13db61fd.txt b/output/text/f0821fb7-e99c-47f7-b0ac-075f13db61fd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..308346db8d941020dfbaa17398a0ed0ce12c13aa
--- /dev/null
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+
+--- Page 1 ---
+Patient history: PRE-OP DIAGNOSIS: Colon cancer. POST-OP DIAGNOSIS: Same. PROCEDURE:  Laparoscopic right hemicolectomy.. AMENDED/CORRECTED REPORT: This amendment reflects: 1. The following change: Include the "gross examination only" intraoperative consultation remarks. 2. Where: In the intraoperative consultation field. 3. For the following reason: They were inadvertently omitted from the original report 4. The Final Diagnosis and Synoptic Data remain unchanged. This Amended/Corrected Report supersedes alt prior reports under this accession number and should be the only one used for. patient management. All reports, both original and amended/corrected, are maintained in electronic archives and are available upon request. FINAL DIAGNOSIS: Colon, right hemicolectomy - A. mOderaTELy DIfferenTIateD ADeNOcarcinoma Of tHE aSCenDIng COLOn, 3.5 Cm, INVaSive IntO SUBSEROSA WITH PERFORATION OF THE VISCERAL PERITONEUM B. Proximal TermInal IlEal And DistaL COlOnIc margins Are free Of tumOr. C.  METASTATIC ADeNOcARCINOMA IN ONE OF TWEnTy-TWO LyMPH nODES (1/22). D. PATHOLOgIC STAGE: pT4b N1 Mx.  FIBROUS OBLITERATION OF THE APPENDIX CASE SyNOpSIS: SyNOPTIC DATA - PRImARy COLON, RECTAL, APPENDIX TUmORS Specimen type: Right hemicolectomy TUMOR SITE: Right (ascending) colon TUMOR CONFIGURATION: Infiltrative TumOR SiZE: Greatest dimension: 3.5 cm Additional dimensions: 2.2x0.8 cm INTACTNESS OF MESORECTUM: Not applicable HISTOLOGIC TYPE: Adenocarcinoma Histologic grade: Low-grade (weil to moderately differentiated). Pathologic Staging (ptnm): pT4b pN1: Metastasis in 1 to 3 regional lymph nodes Number of nodes examined: 22. Number of nodes invoived: 1 pMX MARGINS: Proximal margin uninvolved by invasive carcinoma Distal margin uninvolved by invasive carcinoma. Circumferential (radial) margin - Not applicable Mesenteric margin uninvolved by invasive carcinoma ANGIOLYMPHATIC INVASION: Present PERineURAL iNVAsiOn: Absent TUmOR bORDER CONFiGURATIOn: Infiltrating ADDITIONAL TUMOR CHARACTERISTICS:  None AnnITIONAL PATH FINDINGS (check all that apply): None identified
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diff --git a/output/text/f0b9ca1b-24f7-4c98-8d0a-deccbf8beff0.txt b/output/text/f0b9ca1b-24f7-4c98-8d0a-deccbf8beff0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c45b071e9f0d81a8d60295cf75ab857c9d486630
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+FINAL DIAGNOSIS: PART I: BREASL. RIGHT, SEGMENTAL MASTECTOMY -- A.  JNEILTRATING DUCTAL. CARCINOMA, 1.1 CM, NOTTINGHAM SCORE 6/9 (TUBULES 3, NUCLEAR GRADE 2, MITOSIS 1). B.  DUCTAL CARCINOMA IN SITU, SOLID TYPE, NUCLEAR GRADE 2, REPRESENTING 5% OF THE TUMOR VOLUME. C ANGIOLYMPHATIC INVASION IDENTIFIED. D.  INVASIVE TUMOR IS 0.5 CM FROM SUPERIOR MARGIN. E. MARGINS FREE OF TUMOR. F.  CHANGES CONSISTENT WITH BIOPSY SITE. G. FIBROCYSTIC CHANGES. PART 2: RIGHT AXILLA, SENTINEL NODE #1, BIOPSY - TWO LYMPH NODES (0/2), NEGATIVE FOR TUMOR. CASE SYNOPSIS: 1cs-o-3 SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST Curcunoma,ntfttnnftwy duchl,nos 95003 LATERALITy: Right PROCEDURE: Sit: busst, Nos c50.9 Segmenta! 3/3/11 pu LOCATION: Upper outer quadrant SIZE Of TUMOR:  Maximum dimension invasive component: 1.1 cm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: No TUMOR TYPE (invasive component): Ductal adenocarcinoma, NOS NOTTINGHAm SCORE: Nuclear grade: 2 Tubule formation: 3 Mitotic activity score: 1 Total Nottingham score: 6 Nottingham grade (1, 2, 3): 2 ANGIOLYMPHATIC INVASION: Yes DERMAL LYMPHATIC INVASION: Not applicable CALCIFICATION: No Tumor type, in Situ: Solid DCIS admixed with invasive carcinoma Percent of tumor occupied by in situ component: 5 % SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No Distance of invasive tumor to closest margin: 5.0 mm SURG MARGINS INVOLVED BY IN SITU COMPONENT: No PAget's DISEASE Of NIppLE: No UUID:71291A56-C208-4E89-8223-DD7563CB8DC9 LyMPH NODES POSITIVE: 0 TCGA-BH-A0HF-01A-PR Redacted LYMPH NODES EXAMINED: 2 METHOD(S) OF LYMPH NODE EXAMINATION: H/E stain SENTINEL NODE METASTASIS: No ONLY KERATIN POSITIVE CELLS ARE PRESENT: No LYMPH NODE METASTASIS(-ES) WITH EXTRACAPSULAR EXTENSION: No  METASTASES TO IPSILATERAL INTERNAL MAMMARY LYMPH NODE (IF APPLICABLE): No SKIN INVOLVED (ULCERATION): No t stage, pathologic: pT1c N Stage, pathologIc: pN0 m Stage, pathOlOgIc: pMO ESTROGEN RECEPTORS: positive PROGESTERONE RECEPTORS:  positive HER2/NEU: zero or 1+ 3/13/11
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diff --git a/output/text/f0d9750d-180d-4f2c-9899-26d05bf43886.txt b/output/text/f0d9750d-180d-4f2c-9899-26d05bf43886.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a88de7884614e673827abb8c9dbdb7319b2e8415
--- /dev/null
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+
+--- Page 1 ---
+Diagnosis/ diagnoses: Right hemicolectomy preparation with tumor-free oral and aboral resection margins and a hyperplastic polyp in the ascending colon. It also includes an ulcerated, in parts poorly differentiated adenocarcinoma of the cecum with widespread and deep infiltration of the perimuscular fatty tissue (G3, pT3). Follow-up report: Following acetone clarification, 40 lymph nodes in the pericolic fatty tissue bordering the. tumor were prepared, measuring up to 1.5 cm.. These proved to be microscopically tumor-free throughout.. In conclusion and in summary a stage of pT3 pN0 (0/40) L0 V0 R0 is established
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diff --git a/output/text/f0f0bcfe-f9ad-4884-ac35-7616bad552d6.txt b/output/text/f0f0bcfe-f9ad-4884-ac35-7616bad552d6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..68805dcb1fb31fd187cb3cb67d272b32cf6ca1de
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:BF121A0C-1D1B-4F4F-B8A3-C90325BA4FD2 Department of Pathology TCGA-P4-A5EA-01A-PR Redacted Tissue Source Site (Tss) #: Patholgy Accession No: Patient ID Normal Sample ID: Pathology Report ICD O3 DIAGNOSIS Carcnsmc, papillary veral cell (A) LEFT KIDNEY AND ADRENAL GLAND AND PERIAORTIC MASS: -8360/.3 RENAL CELL CARCINOMA, Sitc; C9 Kidney HOS Cb49 - PAPILLARY, TYPE 2, - FUHRMAN'S NUCLEAR GRADE 4 - 4.5 X 4.0 X 3.0 cm 9N r/1o/3 - INVASION INTO THE PERIRENAL SOFT TISSUE - LYMPHOVASCULAR INVASION PRESENT - METASTASIS TO THE PERIRENAL SOFT TISSUE (8.0 X 6.5 X 6.0 cm). Margins of resection (renal artery, renal vein, ureter, perinephric soft tissue), no tumor present. Adrenal gland, no tumor present.. (B) ANTERIOR AORTA, INTER-AORTOCAVAL LYMPH NODES Four lymph nodes, no tumor present. GROSS DESCRIPTION (A) LEFT KiDNEY AND ADRENAL GLAND AND PERIAORTIC MASS - A nephroureterectomy specimen (17.0 x 12.0 x 6.5 cm) including a kidney (11.5 x 6.5 x 7.0 cm), ureter (12.0 cm length, average diameter of 0.5 cm), and adrenal gland (5.0 x 3.0 x 1.0 cm), and attached perinephric fat (9.0 x 7.5 x 2.0 cm).. There is a well-circumscribed tumor (4.5 x 4.0 x 3.0 cm) in the mid portion of the kidney. The cut surface of the kidney  tumor is tan-white and homogeneous. The tumor extends to the perinephric fat and approaches the perinephric fat margin on the  posterior aspect of the specimen within 0.1 cm. The tumor does not appear to extend into the sinus. There is a perihilar lymph  node (8.0 x 6.5 x 6.0 cm) in the attached perinephric fat. Serial sectioning of the hilar lymph node shows a tan-white, firm and  homogeneous cut surface with focal area of hemorrhage and necrosis The uninvolved kidney is tan-brown and grossly unremarkable. The adrenal gland is grossly unremarkable. The remainder of the urothelium of the peivicalyceal system is grossly unremarkable.. Representative sections are submitted in A1-A21. Representative sample of the tumor is submitted for electron microscopy (on hold). INK CODE: Blue - retroperitoneal fat margin.  SECTION CODE: A1, vascular and ureter margin; A2, adrenal gland; A3, tumor and perirenal soft tissue; A4-A6, tumor  and renal sinus; A7-A12, tumor; A13-A18, representative sections of the perihilar lymph node; A19, A20, uninvolved kidney; A21, renal pelvis. (B) ANTERIOR AORTA INTER-AORTOCAVAL LYMPH NODES - An irregular fragment of adipose tissue (5.0 x 2.0 x 1.0 cm). Four lymph nodes are identified ranging from 0.4 x 0.4 x 0.2 to 1.0 x 0.8 x 0.4 cm.. SECTION CODE: B1, B2, one lymph node serially sectioned; B3, three lymph nodes.. CLINICAL HISTORY None given. SNOMED CODES T-71000, M-Y7343 "Some tests reported here may have been developed and performance characteristics determined by These tests have not been specifically cleared or approved by the U.S. Food and Drug Administration." -END OF REPORT- () 12(31/1)
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diff --git a/output/text/f144a01b-f878-4906-9478-0849e5ee0316.txt b/output/text/f144a01b-f878-4906-9478-0849e5ee0316.txt
new file mode 100644
index 0000000000000000000000000000000000000000..cdb97655a41c0e898d9d3408bb86be82c407b8a1
--- /dev/null
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+
+--- Page 1 ---
+UUID: 22298C81-A72D-4E22-99DD-6541FB0953A4 TCGA-OR-A5KZ-01A-PR Redacted Procedure: adrenalectomy Gross description: 14 x 9 x 5cm, 336g Reference Pathology only: Diagnosis: adrenocortical carcinoma, with unusually high proliferation rate, Kl67 60% Weiss score: 8. Hough score: 4.89. IcD-6-3 Van Slooten score: 22.7 Corcinomo,adrenalcsrtice! 837o/3 Site: Ad^enol Gkerd Cortex. C74 c HS 3/6/13
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diff --git a/output/text/f1524560-befd-46cb-a679-6f1ede326349.txt b/output/text/f1524560-befd-46cb-a679-6f1ede326349.txt
new file mode 100644
index 0000000000000000000000000000000000000000..84e7d1d5299a5e5ff674d6510c36025ab0cdc289
--- /dev/null
+++ b/output/text/f1524560-befd-46cb-a679-6f1ede326349.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Patient Name Accession #: Med. Rec. #: Date of Procedue DOB Dato of Receipt Gender: Date of Report: Rof. Physician: Account #: Patient Address: Billing Type Additional Copy to: Rel. Source: gnosis & History: vith teft renal mass. Specimens Submitted: 1: Sp: Left kidney and adrenat glan. 2: SP: Left para-aortic lymph nodes. 3: SP: Lelt retroperitoneal fa DIAGNOSIS: 1) KIDNEY AND ADRENAL GLAND, LEFT: RADICAL NEPHRECTOMY: - RENAL CELL CARCINOMA. TYPE UNCLASSIFIED, NUCLEAR GRADE IIIIV. - THE PATTERN OF GROWTH IS ACINAR AND PAPILLARY. - THE TUMOR GREATEST DIAMETER IS 11 CM. - THE TUMOR EXTENDS THROUGH THE RENAL CAPSULE BUT IS CONFINED WITHIN GEROTA'S FASCIA - NO INVASION OF THE RENAL VEIN IS IDENTIFIED - ALL SURGICAL MARGINS ARE FREE OF TUMOR  THE NON-NEOPLASTIC KIDNEY IS UNREMARKABLE - THE ADRENAL GLAND SHOWS A 1.7 CM ADRENOCORTICAL ADENOMA - THE LYMPM NODE STATUS IS AS FOLLOWS (EXPRESSED AS THE NUMBER OF METASTATIC NODES IN RELATION TO THE TOTAL NUMBER OF NODES EXAMINED):RENAL HILAR:O/3 2) LYMPH NODES.LEFT PARA-AORTIC; EXCISION: - EIGHT BENIGN LYMPH NODES (0/8). 3) ADIPOSE TISSUE, LEFT RETROPERITONEAL: BIOPSY - BENIGN ADIPOSE TISSUE. I ATTEST THAT THE ABOVE DIAGNOSIS IS OASED UPON MIY PERSONAL EXAMINATION OF THE SLIDES (ANDOR OTHER NATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORI Special Studies: Special Stain Comment Result RECUT RECUT RECUT Page t of 3
+
+--- Page 2 ---
+1} The specimen is received fresh for frozen section diagnosis, labeled. "Left kidney and adrenal gland (freeze mass)II. consists of a radical nephreclomy specimen measuring 21.0 x 13.0 x 9.0 cm and weighing 1250 grams total.  There is a 11.0 x 0.5.  x 0.5 cm segment of ureler attached. The specimen is inked black and opened to show the kidney measuring 12.0 x 8.0 x 6.0 cm Thore is a 8.0 x 6.0 x 6.0 cm multinodular yellow mass in the corlex extonding into tho perironal fat..  There are also mulliple black firm nodules in the perirenal fat, measuring up to 1.1 cm in greatest dimension. Adjacent to the mass is a 3.0 x 3.0 x 2.0 cm area of kidney,whichis mottled in appearance The remainder of the kidney. pelvis and renal vein are grossly unremarkable without. tunor. The hilum is dissected to show muliple lymph nodes, measuring up to 1.5 cm in greatest dimension. The adrenal gland measuros 6.2 x 3.0 x 1 4 cm and weighs 11 grams.. There is a yellow, woll-encapsulated, corlical nodule, measuring up to 1.7 cm. in greatest dimension. Representative sections are submitted. Summary of Seclions: FSC - trozen section control UM -- ureler margin VM - vascular margin  LN -- hitar lymph nodes T -tumor TC - tumor wilh cortex TP - tumor with pelvis MK-mottled kidney TF - tunmor bulging into tat TNF  tumor nodules in fat M  margin closest to tumor and fat A-adrenal 2} The specimen is received in formalin, labeled "Lelt para-aortic lymph nodes". It consists of mulliple pieces of fibrofalty. tissues moasuring 5.5 x 4.0 x 1.0 cm. Serial sectioning reveats multiple lymph nodes ranging Irom 0.5 up to 1.5 cm in grealest dimension. The largest lymph node was bisected. The nodes were entirely submitled. Summary of Section: LN - jymph nodos BLN - bisocted lymph node 3) The specinen is received in formalin, tabeted "Lelt retroperitoneat fat". It consists of a single piece of unremarkabte fatly tissue measuring 7.0 x 4.0 x 1.0 cn.Represonlative sections submitled.. Summary of Sections. U - undesignated Summary of Sections: Part 1:  SP: Left kidney and adrenal glan Block Sect. Site. PCs 5 A 5 1 FSC 1 2 LN 3 1 M 1 2 MK 2 3 r 3 1 TC 1 2 TF 2 2 TNF 2 1 TP 1 1 UM 1 1 VM 1 Part 2: SP: Left para-aortic lymph nodes (tl). Page 2 of 3
+
+--- Page 3 ---
+Block Sect. Site pCs NN BLN 2 LN 4 Part 3: SP: Left retroperitoneal f Block Sect. Site PCs 1 U 2 Intraoperative Consultation: Note:  The diagnoses given in this section perlain only to the tissue sample examined at the time of tho intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS: RENAL CORTICAL CARCINOM PERMANENT DIAGNOSIS SAME Page 3 of 3 END OF REPORT
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diff --git a/output/text/f1c1d9c1-a4a7-4763-83d9-bcfc00e791ce.txt b/output/text/f1c1d9c1-a4a7-4763-83d9-bcfc00e791ce.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6966719e289c72d3d452f975e9baa2b46708e399
--- /dev/null
+++ b/output/text/f1c1d9c1-a4a7-4763-83d9-bcfc00e791ce.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+SPECIMENS: A. TERMINAL ILEUM AND RIGHT COLON DIAGNOSIS: A. TERMINAL ILEUM AND RIGHT COLON, RIGHT HEMICOLECTOMY: - MODERATELY TO POORLY DIFFERENTIATED ADENOCARCINOMA OF CECUM, TUMOR SIZE 4.5 x 3.2 CM, INVADING INTO SUPERFICIAL MUSCULARIS PROPRIA. - SURGICAL RESECTION MARGINS, NEGATIVE FOR TUMOR.  SIXTEEN (16) PERICOLIC LYMPH NODES, NEGATIVE FOR TUMOR (0/16). - TWO (2) HYPERPLASTIC POLYPS IN COLON. - VERMIFORM APPENDIX, NEGATIVE FOR TUMOR. - SEE TEMPLATE. COLORECTAL CANCER TEMPLATE Specimen Type:  Right hemicolectomy Tumor Site: Cecum Tumor Configuration: Exophytic (polypoid) Tumor Size: 4.5 x 3.2 x 1.0 cm Histologic Type: Adenocarcinoma Histologic Grade: Moderately differentiated to poorly differentiated Extent of Invasion: Superficial muscularis propria. Margins:  Margins uninvolved by invasive carcinoma Venous/Lymphatic Invasion: Absent. Perineural Invasion: Absent Additional Pathologic Findings: Hyperplastic polyps Extent of Resection: Ro: Complete resection with grossly and microscopically negative margins Lymph Nodes: Negative (0/16) Implants: Absent Pathologic Stage: pT2 N0 Mx SPECIMEN(S): A. TERMINAL ILEUM AND RIGHT COLON CLINICAL HISTORY:  None given INTRAOPERATIVE CONSULTATION DIAGNOSIS: FSA: Colon and ileum, resection: Tumor at 9cm from proximal margin. GROSS DESCRIPTION: A. TERMINAL ILEUM RIGHT COLON Received fresh labeled as "terminal ileum right colon" is a 28cm in length right colon and terminal ileum.. The specimen is opened to reveal a tumor mass at the cecum measuring 4.5x3.2x1.0cm. The mass is. sessile/ polypoid and raised. The mass is 1.5cm from the cecal valve and is 9 cm from the closest surgical resection margin. The serosa is inked blue corresponding to the lesion. The mass is sectioned. and does not appear to go through the mucosa. There are two other tan polypoid lesions noted on the mucosal surface measuring 0.9 and 1.3 cm. in greatest dimension. There is an attached appendix. measuring 10x1cm. The appendix is serially sectioned and reveals fecal material in the tip. Representative sections are submitted in 12 cassettes as follows: A1-A2: margins A3-A5: tumor A6: 2 presumed polyps A7-A8: representative sections of normal bowel A9: appendix with the proximal portion notched A10: 7 lymph nodes A11: 6 lymph nodes in toto.
+
+--- Page 2 ---
+A12: 3 lymph nodes in toto, 1 bisected lymph node A13: representative section of ileocecal valve A14-A16: other sections of tumor mass 90% of the tumor is submitted.
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diff --git a/output/text/f1cc4fc3-0b87-40aa-846b-8b4c59fcc0f6.txt b/output/text/f1cc4fc3-0b87-40aa-846b-8b4c59fcc0f6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..119ed395ac646872635cb4d1460c268eb30dd444
--- /dev/null
+++ b/output/text/f1cc4fc3-0b87-40aa-846b-8b4c59fcc0f6.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Patient history: ChIEF COmPLAINT/PRE-OP/pOst-Op DIAGNOsIS: Sigmoid colon mass PrOCEDUrE: Sigmoid colon resection SPECIFIC CLINICAL QUESTION: Not answered OUtsiDE TisSUE DiagnOSIS: Not answered PRIOR MALIGNANCY: Not answered CHEMOTHERAPY: Not answered ORGAN TRANSPLANT: Not answered IMMUNOSUPPRESSION: Not answered OtHer DiSEASeS: Not answered FINAL DIAGNOSIS: Collection Date: SIGmoId cOLoN, SEgmenTaL coLEctomy - A. UlCERATED, POLyPOID, INVASIVE, MODERATeLy DIfFErENTIATED, COLONIC ADENOcArCINOMA, 3 CM. PrEsEnT in ThE SiGmOiD COLOn 3 Cm fROm The pROxImAl. AnD 5.5 Cm frOm ThE DiSTAl rESectiON MARGINS. B. Carcinoma invades deeply into, but not through the muscuLaris propria. C: PRESUMED ANGIOLYMPHATIC iNVASION (see diagnosis G). D. ONe SmaLl TuBULar ADenoma. E. ALL SURGICAL RESECTION MARGINS, SUBSEROSAL AND SEROSAL SURFACE ARE BENIGN. . NON-NEOPLASTIC COLONIC MUCOSA WITH NO SIGNIFICANT HISTOPATHOLOGIC ABNORMALITY. G.  METASTATIC COLONIC ADENOCARCINOMA IS PRESENT AND LARGELY REPLACES TWO OF TWELVE (2/12) REGIOnal Lymph NODES. THe LArGEr meTASTaTIC FOcus mEASurEs O.4 Cm. NO exTRacApSULAR ExtenSion is Identified. H.TNM PATHOLOGIC STAGE: T2 N1 MX (see synoptic). CASe syNOpSiS: SyNOPTIC DATA - PRImARy COLON, RECTAL, APPENDIX TUmORS Specimen type:  Sigmoidectomy SPECIMEN LENGTH: 11.5 cm TUMOR SITE: Sigmoid colon TumOR CONFIGUrATION: Exophytic (polypoid) TUMOR SIZE: Greatest dimension: 3 cm Additional dimensions: 3 x 1.7 cm INTACTNESS OF MESORECTUM: Not applicable HISTOLOGIC TYPE: Adenocarcinoma HISTOLOGIC GRADE: Low-grade (well to moderately differentiated) PATHOLOGIC STAGiNG (nTNm): pT2 pN1 Number of nodes examined: 12 Number of nodes involved: 2 pMX Treatment: Untreated MARGINS:  Proximal margin uninvolved by invasive carcinoma Distal margin uninvolved by invasive carcinoma Circumferential (radial) margin - Not applicable. Mesenteric margin uninvolved by invasive carcinoma If all margins uninvolved by invasive carcinoma: distance of invasive carcinoma from. closest margin: 30 mm Margin: Proximal ANGIOLYMPHATIC INVASION: Present PERINEURAL INVASION: Absent TUMOR BORDER CONFIGURATION: Infiltrating ADDITIONAL TUmOR CHARACTERISTICS: None ADDITIONAL PATH FINDINGS (check ali that apply): Adenoma(s)
\ No newline at end of file
diff --git a/output/text/f1cd926b-2f9b-4709-8946-935d0963962c.txt b/output/text/f1cd926b-2f9b-4709-8946-935d0963962c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..72c93afd8fdc5fbc103e2039e0509bd1fbe9cd80
--- /dev/null
+++ b/output/text/f1cd926b-2f9b-4709-8946-935d0963962c.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Patient hIstoRy: CHIEF COMPLAINT/ PRE-OP/ POST-OP DIAGNOSIS: -year-old female with breast ca. Left invasive ductal ca with 4.0 cm of calcification/nris a UOQ inv tubular CA with LCIS. Lmp Date: PROcEDURE: Bilateral total mastectomies, bilateral SNBs, insertion bilateral tissue expanders. SPECIFiC CLiNICAL QUeStiOn: Not answered. Outside tissue Diagnosis: Not answered. PRIOR MALIGNANCY: Not answered. CHEMORADIATION THERAPY: Not answored. Other Diseases: Not answered. CASE SYNOPSIS:  SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREASTE LATERALITY: Let. PROcEDurE: Simple mastectomy LOCATION: Upper outer quadrant Lower outer quadrant SIZE OF TUMOR:  Maximum dimension invasive component: 28 mm  MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: TUMOR TYPE (invasIve component): No Ductal adenocarcinoma, NOS NOttingham ScOre: Nuclear grade: 2 Tubule formation: 1 Mltotic activity score: 1 Total Nottingharn score: 4 Nottingham grade (1, 2. 3): 1 ANGIOLYMPHATIC INVASION: DeRmal Lymphatic invasiOn: No No CALCIFICATION: Yes, benign zones Yes, malignant zones Tumor type, in situ: Cribriform  Micropapillary. SUrgICAl mArGins InVolVeD by InvasIve COmponent:E No Distance of invasive tumor to closest margin: 9 mm SURG MARGINs INVOLVED By iN SITU COMPONENT: No Lymph nodes positive: Lymph nodes examined: 0 1cs-0 -3 method(s) Of Lymph node examinatiOn: 1 H/E stain t Stage, pathologic:  pT2 cicnimu, ifi/tratng ouet NOs N STAGE MODIFIER: N stage, pathologic: (sn)  pN0 850c/3 M stage: Not applicable Estrogen Receptors: Srte: buiot,N0s positive C50.9  PROGESTERONE RECEPTORS: positive HER2/NEU: 1+ 10/151  SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREASTE LATERALITY: PROceDURE: .Right) Simple mastectomy LocatIOn: Uppor outer quadrant Lower outer quadrant Size Of TumOR:  Maximum dimension invasive component: 11 mm  MULTICENTAICITY/MULTIFOCALITY OF iNVASiVE FOCI: TUMOR TYPE (InvasIve component): No Ductal adenocarcinoma, NOS NOTTINGHAM SCORE: Nucloar grade! 2 Tubule formation: 1 UUID:0C158269-A420-4E71-9E59-8775FB260848 Mitotic activity score: 1 TCGA-BH-A0W4-01A-PR Redacted Totai Nottingham score: 4 Nottingham grade (1, 2, 3): 1 ANGIOLYMPHATIC INVASION: DERmAL LyMPHATiC INVASION: NO CALCIFICATIQN: No Yes, benign zones TumOr TyPe, IN SITU: SUAGICAL MARGINS INVOLVED BY INVASIVE COMPONENT:E LCIS No Distance of Invasive tumor to closest margin: 26 mm LyMPH nODES POSITIVE: Lymph nOdes exAmIneD: 0 method(s) of Lymph noDe examination:  H/E stain T stage, Pathologic: pT1c N STAge mODIFIer: (8n N Stage, pathologic: pNO M stage: Not applicable EstrOgen REceptors: Progesterone receptoRs: positive HER2/NEU: positive 1+ Criterila repangy Dual/Syrch Case is{circle 10/1s
+
+--- Page 2 ---
+FINAL DIAGNOSIS: PART 1: LEfT AXILLARY SENTINEL Lymph nODE #1, BIOPSY - ONE LYMPH NODE, NEGATIVE FOR NEOPLASM (0/1). PART 2: RIGHT AXILLARY SENTiNEL LyMPH NODE #1, BIOPSY -- ONE LYMPH NODE, NEGATIVE FOR NEOPLASM (0/1). Part 3: Left breast, total mastectomy --  iNVASIVE DUCtAL CARCINOMA, NOTTINgHAm GRADE 1 (nUCLEAR GRADE: 2, TUBULE SCORE: 1, A. MItOTIC AcTIvITy: 1; TOTAL SCORE: 4/9). B.  TUmOR MEASURES 2.8 CM, AND iS IN THE OUTER QUADRANTS AT APPROXImATELY 3 O'CLOCK. C.  NO LYMPHOVASCULAR SPACE INVASION. D. DUCTAL CARCINOMA IN SITU (DCIS), NUCLEAR GRADE 2, CRIBRIFORM AND MICROPAPILLARY TYPES. E. MARGINS ARE NEGATIVE FOR NEOPLASM; CARCINOMA APPROACHES MOST CLOSELY TO THE ANTERIOR MARGIN (0.9 CM). F. CALCiFICATIONS ASSOCIATED WITH MALIGNANT AREAS AND WITH BENIGN AREAS. G. RADIAL SCAR. H. SCLEROSING ADENOSIS AND FIBROCYSTIC CHANGES. I. CHANGES CONSISTENT WITH PREVIOUS BIOPSY SITE. J.  NIPPLE SKiN IS NEGATIVE FOR NEOPLASM. K.  TUMOR CELLS (LEFT BREAST) PREVIOUSLY REPORTED TO RF POSITIVE fOR ER AND PR, NEGATIVE FOR HER-2 AND TO HAVE A LOW KI-67 INDEX  PATHOLOGIC STAGE: pT2 pN0 pMX. Part 4: righL Breast, total mastectomy -- A. INVASIVE DUCTAL CARCINOMA WITH TUBULAR FEATURES, NOTTINGHAM GRADE 1 (NUCLEAR GRADE 2, TuBule score 1, mitotic activity 1, total Score 4/9). B. TUMOR MEASURES 1.1 CM AND iS LOCATeD APPROXIMATELY AT 9 O'CLOCK. C.  NO LYMPHOVASCULAR SPACE INVASION. D.  MARGINS ARE NEGATIVE FOR NEOPLASM; CARCINOMA APPROACHES MOST CLOSELY TO THE ANTERIOR MARGIN (2.6 CM). E. LOBULAR CARCINOMA IN-SITU (LCIS). F. ATYPICAL DUCTAL HYPERPLASIA AND FLAT EPITHELIAL ATYPIA. G. RADIAL SCAR. H. BIOPSY SITE CHANGES. I. FIBROCYSTIC CHANGES, ASSOCIATED CALCIFICATIONS, AND SCLEROSING ADENOSIS.  NIPPLE SKIN IS NEGATIVE FOR NEOPLASM. K TumOR CELLS (rIghT BREASt) PreVIOUSLy REPQRIeD TO BE POSITiVE fOR eR AND PR, nEGATIVE FOR HER-2, AND TO hAVE A LOW Ki-67 iNDEX L.  PATHOLOGIC STAGE pT1c pN0 MX. PARt 5: LEft ADDITIOnAl BReaSt SkIn, EXcISIOn --  SKIN AND ATTACHED BREAST TISSUE, NEGATIVE FOR NEOPLASM. PART 6: RIGht ADDiTIONAL BREaST SKIN, EXCISION - SKIN AND ATTACHED BREAST TISSUE, NEGATIVE FOR NEOPLASM.
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diff --git a/output/text/f1d36b63-0bae-454d-b7b6-caacd00d1fc0.txt b/output/text/f1d36b63-0bae-454d-b7b6-caacd00d1fc0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..da6b159d9f3ae83573a7ab39312a442a671e6087
--- /dev/null
+++ b/output/text/f1d36b63-0bae-454d-b7b6-caacd00d1fc0.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Eftrs8 BREAST TISSUE CHECKLIST Specimen type: Mastectomy Specimen size: Not specified Tumor site: Breast Tumor size: 2.3 x 1.8 x 1.8 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal and lobular carcinoma Histologic grade: Tumor extent: Not specified Lymph nodes: 0/4 positive for metastasis (Regional 0/4) QLeff, upper Extracapsular invasion of the lymph nodes: Not specified outer Margins: Not specified quadrant E-0-9s Nottingham Histologic Score Tubule formation: Not specified aeereeed Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None.
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diff --git a/output/text/f1d3f914-8bab-49e9-b78f-b384f6393c7d.txt b/output/text/f1d3f914-8bab-49e9-b78f-b384f6393c7d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..32153dd9044990dacc45a18f3b42c62839dbd3b9
--- /dev/null
+++ b/output/text/f1d3f914-8bab-49e9-b78f-b384f6393c7d.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+. Final Diagnosis east, right, wide local excision: Invasive ductal carcinoma, Nottingham grade 2 (of 3), forming a 2.5 x 2.1 x 1.0 cm mass(AJCC r2). Ductal carcinoma in situ, solid type, without necrosis and high nuclear grade identified. Angiovascular invasion present.. After, re-excision of inferior and deep margins, all margins are negative by at least 1.0 cm. Skin ellipse identified without. abnormality. Lymph nodes, right axillary sentinel, excision: Multiple (2 of 5) sentinel lymph nodes are positive for metastatic breast carcinoma (AJCC pN1). Lymph nodes, right axillary, excision: Multiple (7) right axillary lymph nodes are negative for tumor.. Estrogen/progesterone analysis and Her2/Neu have been ordered on paraffin embedded tissue. /cs-0-3 Carcinoma,mfiDtrntn9 cuctaL,Nos 85oof3 Sit, bust, Nos C50.9 lw 4/25/1 UUID: BF82AD23-B40E -459F -83EC-590D392664FD Redacted
\ No newline at end of file
diff --git a/output/text/f1d77648-3501-4a54-8187-7f595a16a8fc.txt b/output/text/f1d77648-3501-4a54-8187-7f595a16a8fc.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3f5b8051bed18f0ab2dbce5780eff93dcac1a97a
--- /dev/null
+++ b/output/text/f1d77648-3501-4a54-8187-7f595a16a8fc.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Histopathology Report Fina Final Received Date/Time Reporting Information. Date/Time : Final Histopathologist : Laboratory Consultant-In-Charge Final Final Submitting Physician Histopathology Report. Final DIAGNOSIS Caecal biopsy: - Malignant lymphoma, consistent with large B cell lymphoma. GROSS DESCRIPTION The specimen is received in formalin, labelled with patient's data, and designated "colonic biopsy". It consists of 3 pieces of tissue measuring 0.2cm to 0.4cm in greatest dimension. (Al{inked blue}; no reserve) MICROSCOPIC DESCRIPTION Sections show 3 pieces of colonic mucosa featuring infiltrating sheets of intermediate to large malignant cells, sparing the crypts and causing focal surface erosion. Immunohistochemical studies done show: CD 3 Negative CD 5 Negative CD 10 Negative CD 20 Positive CD 21 Negative CD 23 Negative Bcl-2 Positive Bcl-6 Positive Cyclin D1 Negative D2-40 Negative MUM 1 Positive MIB-1 High with >80% of lesional cells demonstrating positivity Pathologist  Printed from:
\ No newline at end of file
diff --git a/output/text/f1d93516-f334-405b-bd61-8cc765d95c69.txt b/output/text/f1d93516-f334-405b-bd61-8cc765d95c69.txt
new file mode 100644
index 0000000000000000000000000000000000000000..28e70edd21b81aa5de6305a19f05446c5a574ecd
--- /dev/null
+++ b/output/text/f1d93516-f334-405b-bd61-8cc765d95c69.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UUID: B3884493-D0D3-445C-B9BB-BC475021EBA4 SURGICAL PATHOLOGY TCGA-AQ-A54O-01A-PR Redacted Case Number : Diagnosis: A: Sentinel lymph node, right axillary #l, removal. - No evidence of metastatic carcinoma in one lymph node (0/1) - See comment B: Breast, right, total mastectomy TC DO-3 Tumor type: Infiltrating ductal carcinoma. Carcinomc, Infi /trc tig Duct Nottingham combined histologic grade: 3 Tubule formation score: 3 8Soo/3 Nuclear Pleomorphism Score: 2 Site: (R) Breast, LOQ Mitotic count score: 3. Rth, C50.3 Focality of tumor: unifocal CgcF c5o.y Tumor size (greatest dimension): 35 mm FO iQ/12|1Q Lymphovascular invasion: not identified. In Situ Component: Minor component of ductal carcinoma in situ, cribriform and solid types, nuclear grade 2 with necrosis, 2mm in linear extent Extensive intraductal component: absent Nipple/skin involvement: not identified. Margin status: Invasive component: negative, widely clear; 1.5 cm to closest posterior margin In Situ component: negative; widely clear of all margins Axillary lymph nodes: Total number with metastasis: 0 Total number examined: 14 ( see parts A & C) Microcalcifications: not identified
+
+--- Page 2 ---
+Other findings: gynecomastia, biopsy site changes See report of prior biopsy ( ) for results of ER, PR and HER2 immunohistochemical studies AJCC PATHOLOGIC TNM STAGE: pT2 pNO Note: This pathologic stage assessment is based on information. available at the time of this report, and is subject to change pending clinical review and. additional information. C: Lymph nodes, right axillary, removal - No evidence of metastatic carcinoma in 13 lymph nodes (0/13) - See comment. Comment: The axillary lymph nodes reveal lymphoid paracortical expansion, which is favored to be reactive in nature by H & E stains. Scattered pigmented histocytes are present suggestive of dermatopathic lymphadenitis. Additional immunohistochemical stains are pending to further evaluate this. process, results. of which will follow in an addendum report.. Intraoperative Consult Diagnosis: Frozen section consultation was requested at. on - by in OR FSAl,A2: Lymph node, right axillary SLN #l, biopsy. - No tumor seen Drs. at Frozen Section Pathologist:, MD Clinical History: with right poorly differentiated invasive ductal carcinoma, Grade 3.
+
+--- Page 3 ---
+Gross Description:. Received are three appropriately labeled containers. Container A is additionally labeled "right axillary SLn #l, hot + blue." The specimen is a 6 x 4.5 x 1.5 cm fatty soft tissue fragment. Examination of the. fat reveals a 2.0 x 2.0 x 1.0 cm blue lymph node candidate. This candidate is serially sectioned and submitted entirely in blocks FsAl and FSA2. Container B: Specimen fixation: formalin Time in fixative: 28.5 hours Type of mastectomy: simple mastectomy Weight of specimen: 950 grams Size of specimen: 26.0 cm medial to lateral, 26.7 cm superior to inferior, 4.0 cm anterior to posterior Orientation of specimen: Sutures: Short-superior, long=lateral Inking: anterior-blue, posterior=black, lateral=yellow Skin ellipse dimensions: 18.6 x 9.3 cm Nipple/areola: Nipple, 1.0 cm; areola, 3.1 cm Axillary tail: submitted separately Biopsy site: present; Location is central breast/lower outer quadrant; Size: 0.8 x 0.5 x 0.5 cm Appearance: Biopsy site (clip identified) is in the center of a white/tan, firm area. Hemorrhage and fat necrosis are noted in this area. Additional residual tumor is present. Discrete Mass(es): present Number of discrete masses: one
+
+--- Page 4 ---
+Size of mass (es)/biopsy site: 2.5 x 2.0 x 3.5 cm Location of mass(es): subareola/lower outer quadrant Distance of mass/biopsy site from surgical margin: The mass. measures 1.9 cm to posterior margin, 8.5 cm to inferior margin, 10.5 cm to superior margin, 2.8 cm to anterior margin and is widely clear of medial/lateral margins. Gross involvement of skin or fascia/muscle by tumor: absent Descripti. remaining breast: consistent with yellow/tan fibroad': issue with increased fibrous areas noted in the subareolar area; no other masses are identified. Other remarkable features: none. Tissue submi+: sd for special investigations: yes; Tumor to Tissue Pr. ment Block Summary: (Inking: blue-anterior, black-posterior, yellow=lateral) B1 - nipple. B2 - areola B3 - biopsy site B4 - medial aspect of mass B5-B8 - central portion of mass B9 - lateral aspect of mass B10 - mass to posterior margin B11 - representative dense fibrous tissue posterior to nipple. and anterior to mass B12 - closest skin margin (inferior areola). B13 - upper inner quadrant B14 - lower inner quadrant B15 - lower outer quadrant B16 - upper outer quadrant B17 - mass to normal breast, superior B18  - mass to normal breast, inferior. Container c is additionally labeled "right axillary contents."
+
+--- Page 5 ---
+The specimen. consists of two fragments of yellow/tan fibroadipose tissue that measures 9.5 x 6.5 x 3.0 cm in aggregate. Within the fibroadipose tissue,. fifteen lymph node candidates are identified. These range in size from 0.4 up to 1.5 cm in greatest dimension. The largest lymph node candidate measures 2.3 x 1.5 x. 1.0 cm. Block summary: C1 - six lymph node candidates. c2 - five lymph node candidates (bisected node inked black). c3 - three lymph node candidates (bisected nodes inked black, blue and yellow) C4 - one lymph node candidate, sectioned. c5 - one lymph node candidate, sectioned C6 - one lymph node candidate, sectioned c7,c8 - largest lymph node candidate, sectioned. Procedures/Addenda: Addendum Addendum Immunohistochemical studies were performed on representative blocks of axillary lymph nodes (c6 and c7) and the results are as follows:. cD20: Highlights many small lymphocytes in a generally nodular distribution cD3: Highlights majority of lymphocytes with focal expansion of the paracortex Interpretation: The immunohistochemical studies highlight an. essentially normal pattern of distribution of B cells and T cells in the lymph nodes, with primary. follicles composed predominantly of small B lymphocytes and a. paracortex populated by predominantly small T lymphocytes. Morphologic and. immunohistochemical findings are compatible with reactive lymph nodes and do not support a diagnosis of a lymphoproliferative disorder. The mild. paracortical expansion can be seen as a feature of dermatopathic. lymphadenopathy.
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diff --git a/output/text/f210c3ea-93a9-424e-b674-d39f60fcbce4.txt b/output/text/f210c3ea-93a9-424e-b674-d39f60fcbce4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8536eb2c79d8e8ea0ac170de55e884ec69e5959b
--- /dev/null
+++ b/output/text/f210c3ea-93a9-424e-b674-d39f60fcbce4.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UUID:60008E3E-7CD4-4DB5-83C0-3273B7F962F6 TCGA-FD-A3SL-01A-PR Redacted Gender: Male DOB: Race: Report Date: icd-o-3 Pathology Report: Carc`nomq,wnnia1,nX5s 81ao}3 Sik: path: biscdcr,N05 Surgical Pathology Report C67.9 FINAL PATHOLOGIC DIAGNOSIS Cgcf: biaddr,wa11, A. Left pelvic lymph nodes; biopsy: - Matted lymph nodes with metastatic urothelial carcinoma. pOs+rior c67.4 - Lymphovascular and extranodal invasion present B. Left pelvic lymph nodes; biopsy: y-9-1z - Matted lymph nodes with metastatic urothelial carcinoma. kD - Lymphovascular and extranodal invasion present C. Left pelvic lymph nodes; biopsy: - Three lymph nodes with metastatic urothelial carcinoma (3/3) - Lymphovascular and extranodal invasion present D. Right pelvic lymph nodes; biopsy: - Thirteen lymph nodes with metastatic urothelial carcinoma (13/13) - Lymphovascular invasion and extranodal extension present E. Bladder and prostate; radical cystectomy: - Invasive urothelial carcinoma (3.4 cm in greatest dimension);, see parameters - Ulcerated urothelium with granulomatous inflammation consistent with treatment effect - Polypoid cystitis with urothelial hyperplasia F. Ileocecum; ileocectomy:. - Metastatic urothelial carcinoma (3.5 cm in greatest dimension), full. thickness involvement - Two lymph nodes with metastatic urothelial carcinoma (2/2) - Tubulovillous adenoma - Margin free of tumor Urothelial Carcinoma Pathologic Parameters 1. Tumor type: Urothelial carcinoma 2. Grade of tumor:
+
+--- Page 2 ---
+High grade 3. Depth of invasion: Extravesicular soft tissue or adjacent organ: prostate and seminal vesicles 4. Tumor distribution: Multifocal, largest size 3.4 x 2.2 x 1.5 cm Dome Anterior wall Posterior wall 5. Ureteral margins: Negative (tumor present in left periureteral soft tissue) 6. Distal urethral margin: Negative 7. Soft tissue margin or serosa:. Positive (E6) 8. Lymph nodes: Positive matted left pelvic lymph nodes; positive right pelvic lymph nodes. (13/13) 9. pTNM: pT4a, N2, M1 Effective : this Checklist utilizes the edition TNM staging system for Bladder of the American Joint Committee on Cancer (AJCC) and the International Union Against Cancer (UICC). xxx [] m.D. Interpretation performed by the Attending Pathologist and reviewed with the Resident/Fellow, [] MD Electronically Signed Out by [], M.D. Clinical History: The patient is a: -year-old male with high-grade papillary urothelial carcinoma invasive into muscularis propria undergoing radical cystectomy with neobladder. Specimens Received: A: Left pelvic lymph nodes. B: Left pelvic lymph nodes. C: Left pelvic lymph nodes D: Right pelvic lymph nodes.
+
+--- Page 3 ---
+E: Bladder, prostate F: Ileocectomy Gross Description: The specimens are received in six containers each labeled with the patient's. name and medical record number.. A. The first container is additionally identified as, "left pelvic lymph nodes". Received fresh and placed in formalin is an aggregate of fibrous adipose tissue measuring 5.0 x 3.6 x 1.5 cm. The specimen is consistent with matted firm lymph nodes measuring 4.1 cm in greatest dimension. The lymph node aggregate is serially sectioned and submitted in cassettes A1-A6. B. The second container is additionally identified as, "left pelvic lymph nodes". Received fresh and placed in formalin is an aggregate of dense fibrotic tissue and matted lymph nodes measuring 7.1 x 3.7 x 2.3 cm. Representative sections of largest matted lymph node are submitted in cassettes B1-B5, and smaller fibrotic lymph node is submitted in cassette B6.. C. The third container is additionally identified as, "left pelvic lymph nodes". Received fresh and placed in formalin are multiple ovoid soft tissue fragments measuring in aggregate 5.5 x 4.5 x 1.2 cm. Upon examination several apparent lymph nodes are identified ranging in size from 0.2-1.5 cm in greatest dimension which is submitted as follows: C1: 1 sectioned lymph node C2: 2 lymph nodes C3-C6: 4 lymph node candidates, each cassette D. The fourth container is additionally identified as, "right pelvic lymph nodes". Received fresh and placed in formalin are multiple soft and rubbery fiber adipose tissue fragments measuring in aggregate 9.5 x 6.5 x 2.5 centimeters. The largest piece measures 6.7 x 4.2 x 2.2 cm and represents firm  matted lymph nodes Up on examination multiple apparent matted lymph nodes and. lymph node candidates identified ranging in size from 0.3-2.4 centimeters. Lymph nodes are submitted as follows:. D1-D3: Representative sections of largest matted lymph node. D4-D5: Representative sections of second largest matted lymph node D6-D7: 3 lymph nodes, each cassette D8: 1 matted lymph node D9: 1 sectioned matted lymph node. D10-D11: 1 sectioned matted lymph node D12: 4 lymph node candidates E. The fifth container is additionally identified as, "bladder/prostate" Received fresh and placed in formalin is a 316.9 g, 16 x 9 x 4.8 cm cystoprostatectomy specimen consisting of a 6.5 x 6 x 2.5 cm bladder with
+
+--- Page 4 ---
+attached mesenteric fat and a focal and 5 x 4 x 2.8 cm prostate. The right seminal vesicles measure 4 x 2 x 1.5 cm and right vas deferens measures 10 cm. The left seminal vesicles measures 3.5 x 2 x 1 cm and left vas deferens measures 12 cm. The right ureteral stump measures 1.4 x 0.4 cm, the left measures 1.0 x 0.4 cm, and both demonstrate intact, patent lumens. The ureteral margin has jagged appearance and measures 0.1-0.4 cm in length and 0.5 cm in diameter. The right half of the prostate and bladder is inked blue and the left half is inked black. The bladder and prostate are opened anteriorly along the urethra. The prostate is surrounded by a thin, intact membranous capsule which is partially disrupted at anterior surface and sectioning demonstrates rubbery, pink-tan, peri-urethral nodularity with no discrete masses or indurations. The opened bladder reveals a 3.4 x 2.2 cm shaggy, deep red tan ulceration located in posterior wall and bladder dome. This ulcerated area is located 5 centimeters from distal urethral margin, 0.4 cm from right ureter orifice and 0.6 cm from left ureter orifice, but does not involve ureters or trigone area On cut section, the ulcerated area is superficial, measuring up to 0.3 cm in thickness, and grossly involves underlying densely fibrotic muscularis propria. It is located 1.8 cm from the deep inked margin. The surrounding bladder mucosa is edematous, congested, pink-tan with a uniform 0.3 cm wall thickness. Bilateral ureteral orifices, adjacent to the trigone, are identified and probe patent. Representative sections are submitted as follows: E1: Left ureter resection margin E2: Right ureter resection margin E3: Distal urethral margin E4: Distal prosthetic margin (apex) E5-E8: Bladder Ulceration E9: Bladder dome adjacent to ulcer E10: Anterior wall. E11: Posterior wall. E12-E14: Representative right lobe of prostate from apex to base. E15-E17: Representative left lobe of prostate submitted from apex to base E18: Bilateral seminal vesicles E19: Bilateral vas deferens F. The sixth container is additionally identified as, "ileocecectomy". Received fresh and placed in formalin is an ileocecectomy specimen composed of a 10 cm segment of terminal ileum attached to a 16.5 cm segment of proximal colon. The serosa is pink-tan, smooth, glistening with attached omentum and pericolonic adipose tissue, measuring up to 1.5 cm in thickness. The inner circumference of proximal terminal ileum margin measures 8 cm. The inner circumference of distal colonic margin measures 9 cm. There is stricture at the
+
+--- Page 5 ---
+ileocecal valve with significant narrowing of lumen which measures 4 cm in circumference. The specimen is opened to show tan circumferentially folded.  mucosa with numerous small polypoid lesions in terminal ileum measuring from 0.1-0.3 cm in diameter. The large bowel mucosa is tan, edematous, and contains an area of retracted mucosa measuring 3.5 x 1.5 cm which is adjacent to ileocecal valve. The segment of large bowel has a wall thickness ranging from 0.4-0.8 cm and significant fibrotic thickening up to 1.5 cm underneath retracted mucosa. There is a sessile polyp measuring 0.7 x 0.4 x 0.4 cm which is located. 1.4 cm from the distal margin which is inked blue. There is also an ulcerated area measuring 0.6 x 0.4 cm which is located 2.8 cm from the distal margin. Serosa overlying ulcerated area inked black. The attached adipose tissue is dissected for lymph node candidates. Three lymph nodes are identified ranging. in size from 0.2-0.7 cm. Appendix is submitted with the specimen and measures 5.2 cm in length and 0.6 cm in diameter. The appendiceal serosa is pink-red and glistening and sectioning shows a patent, pinpoint lumen and a wall thickness of 0.2 cm. Block summary: F1: Proximal resection margin F2: Distal resection margin. F3: Ulcerated area, colon F4: Polyp, colon F5: Retracted mucosa, proximal cecum F6: Representative ileum with small polyps F7: Representative uninvolved colon F8: ICV F9: Sections of appendix F10: Representative lymph nodes xxxx [],
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diff --git a/output/text/f236a744-c993-4239-bcca-bda04a32c88e.txt b/output/text/f236a744-c993-4239-bcca-bda04a32c88e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7071d81b740b2e05e65bb3d80e3ff5bd1111b05a
--- /dev/null
+++ b/output/text/f236a744-c993-4239-bcca-bda04a32c88e.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID: 02EBE0C2-AE20-4F08-81E7-3EC45E12C0F4 TCGA-OR-A5KX-01A-PR Redacted ZCD-O -3 83 70/3 Sortica) Procedure: adrenalectomy and nephrectomy Site. AdrenalGlard Cortex C74.Z Gross description: 25 x 17 x 8.5cm with 18cm tumor Q~afb|3 Reference Pathology only: Diagnosis: adrenocortical carcinoma, Kl67 10% Weiss score: 7. Hough score: 5.58. Van Slooten score: 22.7
\ No newline at end of file
diff --git a/output/text/f2551882-a2ca-478e-b678-3c1db9995bc9.txt b/output/text/f2551882-a2ca-478e-b678-3c1db9995bc9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b3c3e21c8be8a7b153b26bcaa540d65af7e32511
--- /dev/null
+++ b/output/text/f2551882-a2ca-478e-b678-3c1db9995bc9.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+/cs-0 -3 Cascnonn, mnfXtratny owct, nos 85oof3 8its: bust Nos C50.9 hs y//1 Procurement Date Laterality:Right, upper outer quadrant Path Report:BREAST TISSUE CHECKLIST Specimen type: Radical mastectomy Specimen size: Not specified Tumor site: Breast Tumor size: 2.4 x 2.4 x 2.4 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinoma Histologic grade: Moderately differentiated. Tumor extent: Not specified Lymph nodes: 0/10 positive for metastasis (Regional 0/10) Extracapsular invasion of the lymph nodes: Not specified Margins: Not specified Nottingham Histologic Score Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified UUID: ED60F792-A71B-4BAE-A536-5FF6D8C3DEAA Mitotic count (40x): Not specified TCGA-E9-A22D-01A-PR Redacted Total Nottingham Score: Score cannot be determined. Evidence of neo-adjuvant treatment: Not specified. Additional pathologic findings: Not specified. Comments: None
\ No newline at end of file
diff --git a/output/text/f2790d55-2ecf-47b8-a373-79288954cf64.txt b/output/text/f2790d55-2ecf-47b8-a373-79288954cf64.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b825ebe9e68db92b5bde5db8bc7f778c9fa01445
--- /dev/null
+++ b/output/text/f2790d55-2ecf-47b8-a373-79288954cf64.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+/cs-0 -3 Circinwmn,mfiltnatm7 dluctl, Nos 85oo/3 Sif: Bust, nos c50.9 Diagnosis: ) 1. Two foci of a moderately differentiated invasive ductal carcinoma. (tumor diameters: 3 cm and 2 cm) with focal intraductal components and circumscribed angioinvasion. No infiltration or ulceration of the skin.. Tumor classification: NOS, G II, pT2(mult)N1aL1V0M1R0 UUID: 5780D50C-5BF0-4392-BC98-894D1369866A Redacted
\ No newline at end of file
diff --git a/output/text/f27ab57a-4b64-4e8c-a87f-e63ada5613c0.txt b/output/text/f27ab57a-4b64-4e8c-a87f-e63ada5613c0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..26b7ff94f180d9e80d5b7314c40ed8c4cc2708b8
--- /dev/null
+++ b/output/text/f27ab57a-4b64-4e8c-a87f-e63ada5613c0.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+TSS ID TSS ID: Oc ID: Date of Procurement Gross Description:  Lump with the tumor of 3.2 x 2.7 cm in size. Ten examined lymph nodes are dense, hyperemic, up to 1 cm in their diameter. Microscopic Description: Infiltrating duct carcinoma; G3. Ten examined lymph nodes demonstrate reactive changes.. Diagnosis Details: Tumor Features: Unknown, Tumor Extent: T2 tumor size more than 2cm not more than 5 cm, Venous Invasion: Absent,. Margins: Absent, Treatment Effect: Comments: JCs-0-3 Formatted Path Report: carinnr nfiIfrstng dut, N0s 85oof3 BREAST TISSUE CHECKLIST sita: busot, Nos c50.9 4/8/+ Specimen type: Lumpectomy Specimen size: Not specified. Tumor site: Lower outer quadrant Tumor size: 2.7 x 0 x 3.2 cm Grossly evident lesion: Yes Histologic type: Infiltrating ductal carcinoma. Histologic grade: Poorly differentiated Tumor extent: Not specified. Lymph nodes: 0/10 positive for metastasis (Axillary 0/10) Extracapsular invasion of the lymph nodes: Not specified. Margins: Uninvolved Nottingham Histologic Score. UUID:FA93BDAA-B56E-4217-9022-4EBE6009FCF7 TCGA-E9-A1RH-01A-PR Redacted Tubule formation: Not specified Nuclear pleomorphism: Not specified Mitotic count (25x): Not specified Mitotic count (40x): Not specified Total Nottingham Score: Score cannot be determined 18
+
+--- Page 2 ---
+TSS iD Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified. Comments: None Laterality: Right, lower outer quadrant.
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diff --git a/output/text/f289b599-26af-4c22-bcbd-333cbaecdc83.txt b/output/text/f289b599-26af-4c22-bcbd-333cbaecdc83.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c40e978ce6d8cd1b362585586532cb65e5f64f12
--- /dev/null
+++ b/output/text/f289b599-26af-4c22-bcbd-333cbaecdc83.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+P.2033 FINAL DIAGNOSIS: part 1: Left sentinel lymph node #1, biopsy - One (1) LYmph nODe. nEgATivE FOR tUmOR (0/1). Part 2: Left sentinel Lymph noDe #2, biopsy -- Eleven Lymph nodes, negative for tumor (o/11). Part 3: _LEet breast, segmental mastectomy - A. iNFILTRATING DUCT CARCINOmA, 0.8 X 0.7 X 0.6 CM B. nOttingham scOre: 7/9 (tusules - 2, nucleI - 2, mitoses - 3). C.  NO LYMPHOVASCULAR INVA$ION IDENTIFIED D. Ductal Carcinoma in Situ, Cribriform type. nuclear GraDe 2, present In The surrounding BREASt TISSUE AnD ASSOCiATED WITH mIcROCALCIFIcATIONS. E. SURGICAL MARGINS NEGATIVE FOR INFILTRATING DUCT CARCINOMA ANO DUCTAL CARCINOMA IN SITU. F. Changes consistent with previous core biopsy site. G. tumor is estrogen receptor positive, progesterone receptor focally and weakLy pOsitive anD.her-2/neu IS negatIvE, sCOre: 0. H. FIBrOcystic Changes. Thermal effect. Je0-0-3 I. c areinoma, mifi9r^aHwg olutl nts 85oo/3 PARt 4: Left BrEaSt, new POsteRiOr marGIn, eXcISiOn - A.  NegatIve fOr tUmOr. sin: srust,nts c50.9 3/13/11 h B. Fibrocystic changes. SYNOPTIC - PRImARY iNVASIVE CARCINOMA OF BREAST LAteraLIty: Lett PROCEDURE: Segmental LOCATION: Not specified SIZE OF TUMOR:  Maximum dimension invasive component: 0.8 cm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: TUMOR TYPE (invasIve component): No Ductal adenocarcinoma, NOS NOTTINGHAM SCORE: Nuclear grade: 2 Tubule fomation: 2 Mitolic activity score: 3 Total Nottingham score: 7 Nottingham grade (1. 2. 3): 2 ANGIOLYMPHATiC INVASION: No DERmAl LymphATIc iNVASiON: Not applicable CALCIFICATION: Yes, malignant zones Tumor type, in situ: Cribriform SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No SURG MARGINS INVOLVED BY IN SITU COMPONENT:  No PAgET'S DISEASE OF NIpPLE: No Lymph noDes positive: 0 LymPh nODeS EXAMINED: METHOD(S) OF LYMPH NODE EXAMINATION: 11 H/E stain SENTINEL NODE METASTASIS: 3//3/1 NON-NEOPLASTIC BREAST TISSUE: FCD No t Stage, pathologic: N stage, pathologic: pT1b m stage, pathologic: pNO UUID:EBAB36DE-A97F-4F8B-806C-EF182519933A Estrogen receptors: pMX TCGA-BH-A0DX-01A-PR Redacted pRogesTerone recepTOrS: poshive HCR2/neU: posltlve zero or 1+
\ No newline at end of file
diff --git a/output/text/f28bbb3b-de11-4d68-9fb6-cba35a52d2eb.txt b/output/text/f28bbb3b-de11-4d68-9fb6-cba35a52d2eb.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7a28e16e8963cc3e0333c10353b22a18678deaec
--- /dev/null
+++ b/output/text/f28bbb3b-de11-4d68-9fb6-cba35a52d2eb.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+LcD-O3 SURGICAL PATHOLOGY Case Number : Site BKudney N0S JCe49 NO 8/9/3 Diagnosis: Kidney, right, nephrectomy Histologic tumor type/subtype: Chromophobe renal cell carcinoma. Sarcomatoid features: None identified Histologic grade (if applicable): Fuhrman grade 4. Tumor size (greatest dimension): 5.2 cm Tumor focality: Unifocal Extent of tumor invasion (if present specify if macroscopic or microscopic) : Capsular invasion/perirenal adipose tissue: Negative. Gerota' s fascia: Negative Renal sinus: Positive; microscopic (slide A9) Major veins (renal vein or segmental branches, Ivc): Negative Ureter: Negative Venous (large vessel): Negative. Lymphatic (small vessel): Negative. Histologic assessment of surgical margins: Gerota' s fascia (nephrectomy): Negative Renal vein (nephrectomy): Negative. UUID:96CB2C5D-A95D-42B0-B42C-3A3C26B6451F Ureter (nephrectomy): Negative. Redacted Adrenal gland: Negative for carcinoma Lymph nodes: Not applicable Other significant findings: None identified AJcc Staging: pT3a pNx This staging information is based on information available at the time of this report, and is subject to change pending clinical review and additional information.
+
+--- Page 2 ---
+Comment: The malignant cells have high grade nuclei and eosinophilic cytoplasm with large vacuolated cells identified adjacent to blood vessels. The malignant cells are immunoreactive for CK7 and E-cadherin but negative for cDl0. The staining pattern for cDil7 demonstrates background staining and is non- contributory. The morphology and immunophenotype are consistent with chromophobe renal cell carcinoma.. Clinical History: -year-old male with right renal mass. Gross Description: Specimen fixation: Received fresh and later placed in formalin. Type of specimen: Radical nephrectomy Side of specimen: Per requisition, right. Size and weight of specimen: The overall size of the specimen is 20.9 x 14.0 x 5.5 cm . The kidney measures 12.5 x 8.0 x 4.5 cm. The overall weight of the specimen is 450 grams. The weight of the kidney (formalin fixed and perinephric fat removed) is 230 grams. Orientation: N/A. The perinephric fat is inked blue at the time of triage. Presence/absence of adrenal gland: There is a 1.6 cm long staple line within the superior aspect and within the staple line there is a 0.4 cm in greatest dimension piece of yellow/orange tissue (may represent adrenal tissue). Tumor site: Mid pole, lateral Tumor description: The tumor has a tan/red soft solid well-circumscribed cut surface.. Tumor size: 5.2 x 5.0 x 4.5 cm Presence/absence of multicentricity: Absent. Confinement/non-confinement to the kidney: Confined Extent of invasion: Perirenal adipose tissue: Does not involve.
+
+--- Page 3 ---
+Gerota' s fascia: Does not involve Renal vein: Does not involve (l.1 cm in diameter) Ureter: Does not involve (6 cm in length x 0.3 cm in diameter) Renal Sinus: Does not involve. Pelvicaliceal: Does not involve Adrenal: Does not involve. Other organs: N/A. Surgical margins:. Perirenal adipose tissue: Negative Renal vein: Negative Renal artery: Negative Ureter: Negative Description of kidney away from tumor: The remainder of the cortical tissue is red/brown, firm with a distinct cortical medullary junction. Hilar lymph nodes: No lymph nodes are palpated. Other significant findings: None Tissue submitted for special investigations: Yes. Tumor and normal are submitted to tissue procurement. Digital picture: Block Summary: Al - Vein artery and ureter margins, en face A2 - Tumor with renal capsule A3 - Tumor and adjacent cortical tissue A4 - Tumor and pelvis A5 - Additional section of tumor A6 - Apparent adrenal tissue. A7 - Kidney away from tumor. A8-A9 - Additional sections of renal sinus fat )7|30[1]
\ No newline at end of file
diff --git a/output/text/f28cd506-87fb-4ff4-aef1-e79072d24dab.txt b/output/text/f28cd506-87fb-4ff4-aef1-e79072d24dab.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0cd00a620b85e77cccf47c19259606c8e5c8a484
--- /dev/null
+++ b/output/text/f28cd506-87fb-4ff4-aef1-e79072d24dab.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+Pathology Report FINAL Report Type .... Pathology Report. Date of Event .... Authored by .... Hosp/Group .... Record Status .... FINAL FINAL DIAGNOSIS: PART 1: LEFT HYPOPHARYNX, BIOPSY INVASIVE SQUAMOUS CELL CARCINOMA PART 2: RIGHT EXTERNAL JUGULAR VEIN AND LYMPH NODE NODE, EXCISION A. ONE (1) LYMPH NODE WITH INTRA AND PERINODAL PAROTID TISSUE, NO TUMOR PRESENT (O/1). B.  VEIN, NO TUMOR PRESENT. PART 3: LYMPH NODES, RIGHT NECK, ZONES II, III, IV, SELECTIVE NECK DISSECTION A. METASTATIC SQUAMOUS CELL CARCINOMA IN ONE OF TEN LYMPH NODES (1/10), LEVEL 4 (0.3 cm). B. NO EXTRACAPSULAR SPREAD PART 4: LYMPH NODES, LEFT EXTERNAL JUGULAR NODE, EXCISION TWO (2) LYMPH NODES, NO TUMOR PRESENT (0/2). PART 5: NERVE, LEFT HYPOGLOSSAL, BIOPSY INVASIVE SQUAMOUS CELL CARCINOMA. PART 6: LYMPH NODES, LEFT NECK, LEVELS II, III, IV, SELECTIVE NECK DISSECTIONI A  METASTATIC SQUAMOUS CELL CARCINOMA INVOLVING SOFT TISSUE (3.2 CM) AT LEVEL 2 WITH ANGIOLYMPHATIC INVASION AND LARGE NERVE PERINEURAL INVASIONS (see comment). B. ELEVEN ADDITIONAL LYMPH NODES, NO TUMOR PRESENT (O/11). PART 7: LARYNX AND LEFT THYROID GLAND, TOTAL LARYNGECTOMY AND THYROID LOBECTOMY A. INVASIVE SQUAMOUS CELL CARCINOMA (4.1 CM), POORLY DIFFERENTIATED INVOLVING LEFT HYPOPHARYNX AND SUPRAGLOTTIS (ARYEPIGLOTTIC FOLD AND FALSE VOCAL CORD) B.  ANGIOL YMPHATIC AND PERINEURAL INVASION PRESENT C. NO CARTILAGE INVOLVEMENT, NO THYROID GLAND INVOLVEMENT. D. PATHOLOGIC STAGE: pT3 N2c (see comment). E. SEPARATE FOCUS OF SUPERFICIALLY INVASIVE SQUAMOUS CELL CARCINOMA (0.4 CM AND 0.1 CM THICK) PRESENT AT VALLECULAR MARGIN, NO ANGIOLYMPHATIC OR PERINEURAL INVASION. F. SEPARATE FOCUS OF CARCINOMA IN SITU ON LINGUAL SURFACE OF EPIGLOTTIS. G.  SEVERE DYSPLASIA ON RIGHT TRUE VOCAL CORD. H.  MODERATE DYSPLASIA PRESENT ON LEFT AND RIGHT FALSE CORDS AND LEFT TRUE CORD. I. LEFT THYROID GLAND WITH NO SIGNIFICANT ABNORMALITY. ONE NORMOCELLULAR LEFT INFERIOR PARATHYROID GLAND WITH HEMORRHAGE. J PART 8: LEFT PHARYNGEAL MARGIN, BIOPSY NO TUMOR PRESENT PART 9: POST CRICOID MARGIN, BIOPSY NO TUMOR PRESENT.
+
+--- Page 2 ---
+COMMENT: For staging and synoptic reporting purposes, the soft tissue deposit in level 2 of the left neck (part 6) is considered a positive lymph node with extensive extracapsular spread, though there is no actual residual lymph node. architecture. Additionally, the vallecular margin is considered positive, albeit involved by a separate primary tumor. Pathologist: ** Report Electronically Signed Out ** By Pathologist: My signature is attestation that I have personally reviewed the submitted material(s) and the final diagnosis reflects that evaluation. GROSS DESCRIPTION: The specimen is received fixed in nine parts. Part 1 is labeled with the patient's name, initials, XX and labeled as "left hypopharynx". It consists of fragments of white-tan soft tissue measuring 1.8 x 1.2 x 0.5 cm in aggregate. The specimen is entirely submitted for frozen section consultation and resubmitted in cassette labeled 1AFS. Pat 2 is received fixed labeled with the patient's name, initials, XX and labeled as "right external jugular vein + node". It consists of a 5.0 x 3.0 x 0.6 cm unoriented fibroadipose tissue. A small stitch is tied to a vessel that is next to an enlarged lymph node (1.5 x 1.5 x 0.6 cm). The stitched end of the vessel is inked blue. The large lymph node is bisected and submitted in cassettes labeled 2A and 2B. The vessel is probe patent and both ends with surrounding tissue are submitted in cassette labeled 2C. Part 3 is labeled with the patient's name, initials, XX and labeled as "right neck levels 2, 3, and 4". It consists of a 10.5 x 3.1 x 1.6 cm unoriented. fibroadipose tissue. The specimen is oriented into part 2, 3, and 4.. Possible lymph nodes are identified ranging in greatest dimension from O.1 to 1.8 cm. Lymph nodes are submitted as follows: 3A one lymph node, 1.8 x 1.4 x 1.2 cm, bisected, level 2 3B one lymph node, bisected level 2 3C possible lymph nodes, level 2 3D two possible lymph nodes, level 3 3E two possible lymph nodes, level 4 3F two possible lymph nodes, level 4. Part 4 is labeled with the patient's name, initials, XX and labeled as "left external jugular node". It consists of two fragments of unoriented fibroadipose tissue measuring 3.5 x 1.5 x 0.5 cm and 3.6 x 1.7 x 0.7 cm. Two enlarged lymph nodes measuring 1.3 x 0.9 x 0.8 cm and 0.7 x 0.6 x 0.5 cm are identified. Tissue is submitted as follows: 4A one bisected lymph node 4B one bisected lymph node 4C remainder of the tissue, entirely submitted. Part 5 is labeled with the patient's name, initials, XX and labeled as "left hypoglossal nerve". It consists of four fragments of tissue measuring 1.0 x 0.5 x 0.2 cm in aggregate. The specimen is totally submitted for frozen section consultation and resubmitted in cassette labeled 5AFS. Part 6 is labeled with the patient's name, initials, XX and labeled as "left neck levels 2, 3, and 4". It consists of a 7.1 x 6.5 x 2.5 cm unoriented. fibroadipose tissue. The specimen is oriented based on the radiographic report and divided into levels 2, 3 and 4. One large possible lymph node measuring 3.2 x 2.2 x 1.8 cm is identified on level 2 and serially sectioned which reveals central necrosis. The possible lymph node was banked for
+
+--- Page 3 ---
+tissue bank. Representative sections of the lymph node are submitted in cassettes 6A and 6B. The remainder of the tissue reveals multiple lymph nodes ranging in greatest dimension from 0.1 to 1.4 cm. Lymph nodes are submitted as follows: 6C four possible lymph nodes, level 3 6D two lymph nodes, level 4 6E four lymph nodes, level 4. Part 7 is labeled with the patient's name, initials, XX and labeled as "total laryngectomy and left thyroid lobectomy". It consists of a total laryngectomy specimen measuring 8.0 x 8.0 x 6.1 cm including 3 trachea rings, hyoid bone, left thyroid lobe (4.0 x 2.0 x 1.1 cm) and a possible parathyroid (2.2 x 0.9 x 0.5 cm) that is attached to the left thyroid gland. Grossly, there is a 4.1 x 3.2 x 1.7 cm, white-tan, firm, hypopharyngeal mass predominantly located in the left pyriform sinus space. The mass has supraglottic extension involving the left false vocal fold. Gross sectioning reveals that the tumor does not involve thyroid cartilage, cricoid cartilage, preepiglottic soft tissue and anterior soft tissue. The tumor is approximately 2.5cm from the anterior soft tissue margin. The left thyroid lobe is serially sectioned and reveals a homogeneous, fleshy, red, unremarkable parenchyma. The tumor is banked for tissue bank. Digital images are taken. Ink code: Black anterior soft tissue margin. Blue preepiglottic soft tissue Orange areas under the hyoid bone Representative sections are submitted as follows: 7A base of tongue margin, shave. 7B right lateral pharyngeal margin, shave 7C tracheal ring margin, shave. 7D anterior soft tissue margin, left side, shave 7E representative section of left thyroid 7F possible left parathyroid 7G right true and false vocal folds 7H DR anterior commissure with thyroid cartilage 7I preepiglottic soft tissue, left side, perpendicular 7J 7K representative section of the tumor 7L DR representative section of the tumor 7M DR tumor and left true and false vocal fold and the thyroid cartilage 7N tumor and left true and left vocal fold 7O anterior adipose tissue for possible lymph nodes.. Part 8 is labeled with the patient's name, initials, XX and labeled as "left pharyngeal margin". It consists of a 2.9 x 0.5 x 0.2 cm tan-white tissue. The tissue is entirely submitted for frozen section consultation and resubmitted in cassette labeled 8AFS. Part 9 is labeled with the patient's name, initials, XX and labeled as "post cricoid margin". It consists of a 1.9 x 0.3 x 0.2 cm white-tan soft tissue. The specimen is totally submitted in cassette labeled 9AFS. F INTRAOPERATIVE CONSULTATION: 1AFS:  LEFT HYPOPHARYNX, BIOPSY (frozen section) A. SUFFICIENT FOR ANCILLARY STUDIES. B. MALIGNANT. C. INVASIVE SQUAMOUS CELL CARCINOMA 5AFS:  LEFT HYPOGLOSSAL NERVE, BIOPSY (frozen section) A. SUFFICIENT FOR ANCILLARY STUDIES
+
+--- Page 4 ---
+B.  MALIGNANT. C.  INVASIVE SQUAMOUS CELL CARCINOMA 8AFS:  LEFT HYPOPHARYNGEAL MARGIN, BIOPSY (frozen section) A. SUFFICIENT FOR ANCILLARY STUDIES. B. BENIGN. C. NO TUMOR 9AFS:  POST CRICOID MARGIN, BIOPSY (frozen section) A. SUFFICIENT FOR ANCILLARY STUDIES. B. BENIGN. C. MILD DYSPLASIA MICROSCOPIC: Microscopic examination substantiates the above diagnosis. caa The following statement applies to all immunohistochemistry, Insitu Hybridization Assays (ISH & FISH), Molecular Anatomic Pathology, and Immunofluorescent Testing: The testing was developed and its performance characteristics determined by the Department of Pathology, as required by the CLIA regulations. The testing has not been cleared or approved for the specific use by the U.S. Food and Drug Administration, but the FDA has determined such approval is not necessary for clinical use. Tissue fixation ranges from a minimum of 2 to a maximum of 84 hours. This laboratory is certified under the Clinical Laboratory Improvement Amendments of ("CLIA") as qualified to perform high-complexity clinical testing. Pursuant to the requirements of CLIA, ASR's used in this laboratory have been established and verified for accuracy and precision. Additional information about this type of test is available upon request. CASE SYNOPSIS: SYNOPTIC DATA - PRIMARY UPPER AERODIGESTIVE TRACT AND SALIVARY GLAND TUMORS SPECIMEN TYPE: Resection: Total laryngectomy and bilateral neck dissection TUMOR SITE: Pharynx, hypopharynx TUMOR SIZE: Greatest dimension: 4.0 cm HISTOLOGIC TYPE: Squamous cell carcinoma, conventional HISTOLOGIC GRADE: G3 PRIMARY TUMOR (pT): pT3 REGIONAL LYMPH NODES (pN): pN2c Number of regional lymph nodes examined: 25  Number of regional lymph nodes involved: 2 Extra-capsular extension of nodal tumor: Present DISTANT METASTASIS (pM): pMX MARGINS:  Margin(s) involved by tumor Location(s): vallecula VENOUS/LYMPHATIC (LARGE/SMALL VESSEL) INVASION (V/L): Present PERINEURAL INVASION: Present ADDITIONAL PATHOLOGIC FINDINGS: Carcinoma in situ Epithelial dysplasia
+
+--- Page 5 ---
+PATIENT HISTORY: CHIEF COMPLAINT/ PRE-OP/ POST-OP DIAGNOSIS: Laryngeal tumor. PROCEDURE: Total laryngectomy, bilateral neck dissection. SPECIFIC CLINICAL QUESTION: Rule out squamous cell carcinoma. OUTSIDE TISSUE DIAGNOSIS: No. PRIOR MALIGNANCY: Yes, prior biopsy larynx, squamous cell carcinoma. CHEMORADIATION THERAPY: No. ORGAN TRANSPLANT: No. IMMUNOSUPPRESSION: No OTHER DISEASES: No. CYTOGENETIC STUDIES: No. HISTO TISSUE SUMMARY/SLIDES REVIEWED: Part 1: Left Hypopharynx Taken: Received:  Stain/cnt Block H&E x 1 AFS Part 2: Right External Jugular Vein and Node Taken: Received:  Stain/cnt Block H&E x 1 A H&E x 1 B H&E x 1 C Part 3: Right Neck Zone 2-4 Taken:  Received  Stain/cnt Block H&E x 1 A H&E x 1 B H&E x 1 C H&E x 1 D H&E x 1 E H&E x 1 F H&E x 1 (none) Part 4: Left External Jugular Node Taken: Received:  Stain/cnt Block H&E x 1 A H&E x 1 B H&E x 1 C Part 5: Left Hypoglossal Nerve Taken: Received: Stain/cnt Block H&E x 1 AFS Part 6: Left Neck 2-4 Taken: Received:  Stain/cnt Block H&E x 1 A H&E x 1 B H&E x 1 C H&E x 1 D H&E x 1 E Part 7: Total Laryngectomy and Left Thyroid Lobectomy Taken: Received:  Stain/cnt Block H&E x 1 A H&E x 1 B
+
+--- Page 6 ---
+H&E x 1 C H&E x 1 D H&E x 1 E H&E x 1 F H&E x 1 G H&E x 1 1 H&E Recut x 1 IEGFR x 1 IBNKNC x 1 J IBNKNC x l J IBNKNC x 1 J IBNKNC x l J IBNKNC x 1 J IBNKNC x 1 J H&E x 1 J HPV x 1 P16 x 1 J V-EGFR x 1 H&E x 1 K H&E x 1 N H&E x 1 0 H&E x 1 HDR H&E x 1 LDR H&E x 1 MDR Part 8: Left Pharyngeal Margin Taken: Received:  Stain/cnt Block H&E x 1 AFS Part 9: Post Cricoid Margin Taken: Received: Stain/cnt Block H&E x 1 AFS TC1
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+UUID:8693580D-FCB3-4943-9C2F-5F3DABFB5AF0 CGA-PE-A5DC-01A-PR SPECIMEN: SURGICAL PATHOLOGY REPORT DOB: Sex: F zCD-O-3 Location: Date Collected. lobulos Date Received' areenone yliltrete NoS 8520|3 Physician: Copy To: paesmrphe Clinical History/Diagnosis: Right Breast Cancer Osirmmo 8520/3 Jobulor Source of Specimen(s): Se R BustNoS c s.9 A: Sentinel Node right axilla B: right Breast Lumpectomy JtO 6/24/J 3 C: final inferior Margin. D: right Axillary Contents Gross Description: Received in four parts.. Source of Tissue: 1. Labeled #1, "sentinel node right axilla". Touch Prenaration Evaluation: 1TPA-1TPB- METASTATIC CARCINOMA PER Gross Description: Received fresh for touch preparation evaluation with patient's name and medical record number labeled "sentinel node right axilla" are two gray-tan blue dye stained lymph nodes, 0.8 and 2.0 cm in. greatest dimension. They are sectioned, touch preparations are made and. representative sections are submitted in two blocks.. Designation of Sections: 1A: 1TPA (representative section), 1B: 1TPB (entire lymph node) Summary of Sections: multiple *** Source of Tissue: 2. Labeled #2, "right breast lumpectomy". Gross Description: Received fresh with patient name and medical record. number labeled "right breast lumpectomy" is a 190 grams, 11.0 x 10.5 x 4.0 cm yellow-tan fragment of breast tissue. There is a short stitch denoting the superior margin and a long stitch denoting the lateral margin. The margins are inked in black, the specimen is serially sectioned to reveal yellow-tan adipose tissue with a moderate amount of dense white-tan connective tissue. There is a 4.0 x 2.5 x 1.8 cm firm mass having tan m353
+
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+gritty cut surfaces with irregular borders. This grossly appears to come. closest to the inked anterior, posterior and inferior margins. Representative sections are submitted in ten blocks. Designation of Sections: 2A- superior, 2B-2C- inferior, 2D- medial, 2E lateral, 2F-2H- anterior, 2I-2J- posterior Summary of Sections: multiple Source of Tissue: 3. Labeled #3, "final inferior margin' Gross Description: Received fresh with patient name and medical record number labeled "final inferior margin" is a 5.0 x 3.5 x 1.6 cm yellow-tan focally blue dye stained fragment of breast tissue. There are two sutures present marking the new margin and this area is inked in black. The specimen is sectioned to reveal yellow-tan adipose tissue with a moderate. amount of dense white-tan connective tissue. Representative sections are submitted in four blocks. Designation of Sections: 3A-3D Summary of Sections: multiple Source of Tissue: 4. Labeled #4, "right axillary contents'. Gross Description: Received fresh with patient name and medical record number labeled "right axillary contents" are 15.0 x 12.5 x 2.5 cm of yellow-tan axillary fat. There are multiple palpable lymph nodes, 0.3 to 2.5 cm in greatest dimension. The lymph nodes are entirely submitted in fourteen blocks. Designation of Sections: 4A- one lymph node, 4B- one lymph node, 4C- one lymph node, 4D- one lymph node, 4E- one lymph node, 4F- one lymph node, 4G-4I- one lymph node, 4J-4N- multiple single lymph nodes Summary of Sections: multiple Final Diagnosis: 1. Sentinel lymph node right axilla, excision: - Metastatic adenocarcinoma in two of two lymph nodes (2/2) with extracapsular extension. 2. Right breast, lumpectomy: - In situ and invasive pleomorphic lobular carcinoma, grade III (4 cm).
+
+--- Page 3 ---
+extending to less than 0.1 mm of the inferior and posterior margins and 0.2 cm from the anterior margin.. - Other margins negative for tumor. - Previous biopsy site changes.. - Extensive angiolymphatic invasion is present Right breast, final inferior margin, excision: 3 - Residual invasive and in situ carcinoma with angiolymphatic invasion. - New margin negative for tumor.. 4. Right axillary contents, regional resection:. - Metastatic adenocarcinoma in three of twenty-nine lymph nodes (3/29) with extracapsular extension. - Axillary breast tissue is present.. Stage pT2,N2,Mx.
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+10s-0-3 Curcinomu, mfi/trstng oluctel, Nos 85oo/3 Site bresh,u0Q C5O.y Sih: brisst,Nos C5o.9. C QcF Diagnosis: Poorly differentiated invasive ductal carcinoma with focal angioinvasion (tumor diameter 2.2 cm). Concluding tumor classification: NOS, G IIl, pT2N1aL1V0R0. UUID:66438290-5D7A-4649-B57D-47A5BA4E8031 Redacted
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+1cs-0-3 Concinma, mfiltnating duct, nos 8500|3 1280 C50.4 TSS CqcF Sits: bUnst,Ns9 c50!q SPECIMENS: A. SENTINEL LYMPH NODE #1 LEFT AXILLA B. LEFT BREAST C. UPPER OUTER QUADRANT LEFT BREAST UUID:42E9A561-B052-412E-B0FD-S63DC097C3C5 D. LEFT AXILLARY CONTENTS TCGA-E2-A140-01A-PR Redacted SPECIMEN(S): A. SENTINEL LYMPH NODE #1 LEFT AXILLA B. LEFt BREAST C. UPPER OUTER QUADRANT LEFT BREAST D. LEFT AXILLARY CONTENTS **************AMENDMENT' This case has been amended to change ER/PR results from pending to final results in the breast synoptic report and add ER/PR and Her2/neu synoptic reports..  INTRAOPERATIVE CONSULTATION DIAGNOSIS: TPA: Sentinel lymph node #1, biopsy: Positive for carcinoma Gross exam B: Left breast, mastectomy: Multiple tumors identified; closest is 1.5 cm from inferior/anterior aspect By Dr called to Dr at GROSS DESCRIPTION: A. SENTINEL LYMPH NODE #1 LEFT AXILLA Received fresh is a tan-pink fragment of fibrofatty tissue (4.0 x 2.0 x 1.0 cm). Dissection reveals a firm presumptive lymph node (1.4 x 1.0 x 0.8 cm). The specimen is serially sectioned and touch preps are taken. Submitted in toto in A1 B. LEFT BREAST Received fresh labeled "left breast" is a 1,184-gram simple mastectomy specimen (27.0 x 25.0 x 6.5 cm) with a stitch on the axillary tail. The specimen is partially surfaced with a tan-pink ellipse of skin (15.0 x 10.5 cm) with a 1 cm centrally located, partially flattened nipple and 3.5 cm areola rim. The skin surface is remarkable for a grey-white,  well-healed scar in the upper outer quadrant measuring 1 cm that is 8.0 cm from the nipple. The specimen is inked and serially sectioned from medial to lateral into 14 slices; slice 1 being most medial, slice 14 being most lateral. The  nipple is located in slice 8. The cut surface reveals a grey-white, firm, stellate mass (6.0 x 5.5 x 4.0 cm) located in the upper central and upper outer quadrants and present in slices 7, 8, 9, 10, and 11. This mass measures 1.5 cm from all margins. A second lesion is located in the 7 o'clock position (0.8 x 0.6 x 0.5 cm) in slice 6. Lesion #2 is Iocated 0.6 cm from lesion #1, and measures 1.5 cm from the closest inferior margin. An ill-defined nodular area (lesion 3) is located 4.5 cm superior to lesion #2 in slice 6 and more than 2.0 cm from the deep margin. A portion of the specimen is submitted for tissue procurement. Gross examination did not reveal distinct 12:00 and 10:00 lesions as designated on the request form. Lesions 2 and 3 may correspond to the 10:00 lesions as they did appear grossly separate from the main tumor mass, although very close. The main mass appeared confluent grossly and may encompass the 12:00 lesion. The remaining cut surfaces reveal predominantly yellow lobulated adipose tissue interspersed with grey-white fibrous tissue. Inked code: Superior anterior -- blue, orange - inferior anterior, black -- posterior. Section code: B1: Nipple serially sectioned, slice 8. B2: Base of nipple, slice 8 B3: Nodular area above lesion #2, slice 6 B4: Lesion #2, slice 6 B5: Inferior margin, slice 6 B6: Deep margin, slice 6 B7: Superior margin, slice 7  B8-B11: Lesion #1 submitted from superior to inferior, slice 7 812: Inferior margin, slice 7 B13: Deep margin, slice 7 B14-B16: Lesion #1 submitted from superior to inferior, slice 8 B17: Inferior margin, slice 8 B18: Deep margin, slice 8 B19-B21: Lesion #1 from superior to inferior, slice 9. B22: Deep margin, slice 9 B23: Deep margin, slice 10 B24: Skin with underlining scar, slice 11  B25-B26: Lesion #1 from superior to inferior, slice 11 B27: Deep margin, slice 11 B28: Area immediately adjacent to lesion #1, slice 12 C. UPPER OUTER QUADRANT LEFT BREAST Received is an unoriented tan-pink fragment of fibrofatty tissue weighing 37 grams and measuring (7.0 x 6.0 x 2.0 cm). The specimen is serially sectioned to reveal predominantly yellow lobulated adipose tissue interspersed with grey-white fibrous tissue. No lesion is grossly identified. Representative sections are submitted in cassettes C1-C4.
+
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+D. LEFT AXILLARY CONTENTS Received labeled "left axillary contents" are multiple tan-pink fragments of fibrofatty tissue aggregating to (10.0 x 9.0 x 3.0 cm). Dissection reveals 17 possible lymph nodes ranging from (0.5 x 0.5 x 0.5 cm to 2.5 x 1.5 x 1.0 cm). Section code: D1: Four possible lymph nodes D2: Four possible lymph nodes D3: Four possible lymph nodes D4-D5: One lymph node serially sectioned D6: One lymph node serially sectioned D7: One lymph node bisected D8: One lymph node trisected D9: One lymph node serially sectioned DIAGNOSIS A. SENTINEL LYMPH NODE #1, LEFT AXILLA, BIOPSY: - METASTATIC CARCINOMA TO ONE LYMPH NODE (1/1). B. LEft BreaSt, mAStecToMy: - MULTIFOCAL INVASIVE DUCTAL CARCINOMA, POORLY DIFFERENTIATEDS (SBR GRADE 3), WITH MICROPAPILLARY FEATURES. - TUMOR SPANS AT LEAST 6 CM AND IS PRESENT IN CENTRAL AREA AND UPPER OUTER QUADRANT - DUCTAL CARCINOMA IN SITU, CRIBRIFORM TYPE, NUCLEAR GRADE 2,E MINOR COMPONENT. - MARGINS, NEGATIVE FOR CARCINOMA. - EXTENSIVE LYMPHOVASCULAR INVASION. - SKIN AND NIPPLE, NEGATIVE FOR CARCINOMA. - SKELETAL MUSCLE, NEGATIVE FOR CARCINOMA C. LEFT BREAST, UPPER OUTER QUADRANT, EXCISION: - FIBROADIPOSE TISSUE, NEGATIVE FOR CARCINOMA. D. LEFT AXILLARY CONTENTS, DISSECTION: - 1/17 LYMPH NODES WITH METASTATIC CARCINOMA WITH EXTRANODAL EXTENSION (1/17). SYNOPTIC REPORT - BREAST Specimen Type: Mastectomy Needle Localization:  No Laterality: Left Invasive tumor: Present Multifocality: Yes WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Tumor size: Size of Invasive focus. 6cm Tumor site: Upper outer quadrant Central Margins:  Negative Distance from closest margin: 1.5cm deep Tubular score: 3 (<10% tubule) Nuclear grade: 3 Mitotic score: 2 Modified Scarff Bloom Richardson Grade: 3 (8-9 points) Necrosis: Absent Vascular/Lymphatic Invasion: Present Extent: extensive Lobular neoplasia:. None Lymph nodes: Sentinel lymph node and axillary dissection. Lymph node status:.  Positive 2 / 18 Extranodal extension DCIS present Margins uninvolved by DCIS DCIS Quantity:Estimate 2% DCIS type: Cribriform DCIS location: Associated with invasive tumor. Nuclear grade: Intermediate Necrosis: Absent
+
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+ER/PR/HER2 Results ER: Positive PR: Positive HER2: Pending Pathological staging (pTN): pT 3 N 1a SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimen: Surgical Excision Block Number: B20 ER: Positive Allred Score: 8 = Proportion score: 5 + Intensity Score 3 PR: Positive Allred Score: 7 = Proportion Score 5 + Intensity Score 2 COMMENT: The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining. 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining). with a scoring range from O to 8. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2. Methodology: Fixation Type and Length: Tissue was fixed in 10% neutral buffered formalin! for no less than 8 and no longer than 24 hours. Antibody and Assay Methodology: Mouse ant-human ER and PK, Comment: Inis assay can - used to select invasive breast cancer patients for hormone therapy (1). ER and PR analysis was performed on this case by immunohistochemistry utilizing the ER (ER 1D5, 1:100) and PR. (PGR 136, 1:100) antibody provided by Dako, following the manufacturer's instructions listed in the package insert This assay was not modified, and adherence to all instruction and guidelines were strictly followed. Interpretation of the ER/PR immunohistochemical staining characteristics is guided by published results in the medical literature (1). information provided by the reagent manufacturer and by internal review of staining performance within the Pathology Department. 1. Harvey JM, et al. Estrogen receptor status by immunohistochemistry is superior to the ligand-binding assay for  predicting response to adjuvant endocrine therapy in breast cancer. J Clin Oncol. 17:1474-1481, 1999 SYNOPTIC REPORT - BREAST HER-2 RESULTS HER2 Status Results, Immunohistochemistry Evaluation. Specimen: Breast Core Needle Biopsy Block Number: B20 Interpretation: EQUIVOCAL Intensity: 2+ % Tumor Staining: 50% Fish Ordered: Yes , on Date METHODOLOGY Methodology: Fixation Type and Length: Tissue was fixed in 10% neutral buffered formalin : ) for no less than 8 and no longer than 24 hours. Antibody and Assay Methodology: Rabbit anti-human HER2, HerceptestTM (FDA-approved test kit), ;. Control Slides Examined: External kit-slides. provided by manufacturer (cell lines witl. nign, low ana neyauve HER2 protein expression), and in-house known. HER2 amplified control tissue were evaluated along with the test tissue. These control slides run along side of this patient's sample showed appropriate staining. Adequacy of Specimen: Adequate, well preserved, clear-cut invasive. carcinoma identified for HER2 evaluation.. Scoring Criterion and Scoring System: IHC Level of Expression(Score) /Tumor Cell Membrane Staining Pattern  Negative (0)/Absence of Staining Negative (1+)/Faint Incomplete membrane Staining, >10% of Cells Equivoca! (2+)/Weak complete membrane Staining, >10% of Cells Positive (3+)/Strong complete membrane Staining, >10% of Cells Equivocal Category for HER2 IHC results: A HER2, 2+ staining result that is interpreted as equivocal may not indicate gene amplification. A FISH test for HER2 gene amplification will be ordered for all HER2 IHC 2+ results. COMMENT This assay can be used to select invasive breast cancer patients for ' ; (Hereptin) therapy (1,2). Clinical Trials have shown that Trastuzumab substantially increases the likelihood for an objective response and overall. survival for patients with metastatic HER2-positive breast cancer, regardless of whether HER2 tumor status was determined as IHC 3+ or FISH positive. Trastuzumab added to adjuvant chemotherapy substantially increase. disease-free survival and decreases the risk of disease recurrence by about 50% for patients with early-stage HER2 protein over-expressed or gene amplified invasive breast cancer (3). HER2 analysis was performed on this case by immunohistochemistry utilizing the FDA approved Dako HercepTest (TM) test kit following the manufacturer's instructions listed in the package insert. This assay was not modified, and
+
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+adherence to all instruction and guidelines were strictly followed. Interpretation of the HER2 immunohistochemical. staining characteristics is guided by published results in the medical literature (4), information provided by the reagent manufacturer and by internal review of staining performance within the Pathology Department.. HER2 TEST VALIDATION This HER2 immunohistochemical assay has been validated according to the recently revised recommendations and. guidelines from the NCCN HER2 testing in Breast Cancer Task Force, and the jointly issued recommendations and guidelines from ASCO and the CAP (5). 80 randomly selected breast cancer samples were tested for HER2 by IHC as outline above and interpreted as, negative (score 0/1+) equivocal (score 2+) and positive (score 3+) without knowledge of the previous reported results.. These cases were also blindly read using two different FiSH assay as amplified or non-amnlified and the HER2/CEP17 ratios were recorded. After analyzing these results, there was 100% concordance between the IHC and FISH results for cases that were interpreted as either positive or negative by IHC. 9 of the 80 cases were interpreted as equivocal by IHC and of these 3/9 (33%) were non-amplified by FISH and 6/9 (66%) were found to be amplified. The Pathology Department Immunohistochemistry laboratory takes full responsibility for this tests performance  and has programs in place to regularly monitor the proficiency and the interpretation of HER2 assays. The Iaboratory also participates in external quality assurance HER2 programs including the CAP proficiency testing program. REFERENCE 1. Carlson RW, Anderson BO, Burstein HJ, et al., NCCN breast cancer clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2005;3:238-289 2. Carlson RW, Brown E, Burstein HJ, et al., NCCN Task Force Report: adjuvant therapy for breast cancer. J Natl Compr Canc Netw. 2006;4:S1-S26. 3. Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Eng J Med 2005;353(16):1673-84 4. Leong ASy, Formby M, Haffajee Z, et al. Refinement of immunohistologic parameters for Her2/neu scoring validation by FISH and CiSH. Appl Immunohistochem Mol Morphol. 2006;14:384-389. 5. Wolff AC, Hammond EH, Schwartz JN, et al., American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Human Epidermal Growth Factor Recepto 2 Testing in Breast Cancer. Arch of Path and Lab Med 2007; 131:18-43. CLINICAL HISTORY: A  year-old female with left multicentric disease, large 4.5 cm mass in upper outer quadrant 10 o'clock + IDC with 3 small masses; 12 o'clock + IDC 5 mm mass PRE-OPERATIVE DIAGNOSIS: None given ADDENDUM: PathVysion HER-2 DNA Probe Kit Case No Analytical Interpretation of Resuits: HER-2 NOT AMPLIFIED Clinical Interpretation of results Amplification of the HER-2 gene was evaluated with interphase fluorescence in-situ hybridization (FiSH) on formalin-fixed paraffin embedded tissue sections using a chromosome 17 centromeric probe and a HER-2 probe that spans the entire HER-2 gene in the by Dr. A majority of tumors cells displayed mild polysomy 17 with 2 to 3 chromosome 17 signals and 2 to 5 HER-2 signals, with a HER-2/CEP 17 Ratio </=2.0, consistent with no amplification of the HER2/neu gene. Block used 820 Source of case:. Tissue fixation formalin-fixed tissueOutside Case No: NA Tissue source breast Results interpreted: yes HER2/CEP17 ratio: 1.65 This ratio is derived by dividing the total number of LSI HER-2/neu signals by the total number of CEP17 signals in at least 20 interphase nuclei with nonoverlapping nuclei in the neoplastic mammary epithelial cells. Cells with no signals or with signals of only one color are disregarded. Method of ratio enumeration:. manual count Limitations The Vysis PathVysion Kit is not intended for use to screen for or diagnose breast cancer. It is intended to be used as an adjunct to other prognostic factors currently used to predict disease-free and overall survival in stage Il, node-positive breast cancer patients. In making decisions regarding adjuvant CAF treatment, all other available clinical information should also be taken into. consideration, such as tumor size, number of involved lymph nodes, and steroid receptor status. No treatment decision for stage II, node-positive breast cancer patients should be based on HER-2/neu  gene amplification status alone. Overview of this test. FDA APPROVED REAGENT PathVysion HER-2 DNA Probe Kit is FDA approved for selection of patients for whom Herceptin therapy is being considered. These tests were performed in the 1, under the direction
+
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+of Dr. The results of these studies should always be interpreted in the context of the clinical, morphological, and immunophenotypic diagnosis.. Gross Dictation: ( Final Review: Pathologist.. Final: Pathologist, . Amendment: Pathologist, - . Amendment Review: Pathologist, Amendment Final: Pathologis'. Addendum: Pathologist, ^.. Addendum Finai: Patholoy.t,.
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+1Cs-0-3 Carcmomay mnifiHt^atng duct, Nos s5o0f3 C50.9 1/37/ Site: bresst, Nos SURGICAL REPORT  Name Pathology Numbe! Sex: F Date Collected: DOB : Date Received: Locarion: M.R. Number: Doctor. Account Number: PRE-OPERATiVe DiAGNOSIS UUID:E1D8F2CB-25F1-49E0-92D3-132DCA8FD533 LEFT 3REAST CANCER TCGA-A2-A0YM-01A-PR Redacted POST-OPERATIVE DiAGNOSIS LEFT 3REAST CANCER PROCEDURE LEFT 3REAST LUMPECTOMY. LEFT AXILLARY SENTINEL MAPPiNG. F.S. TISSUES A. BREAST EXCISION,NEEDLE LOC,SIMPLE,MARGINS,ETC. - LEFT BREAST LUMP B. MARGINS - ADDITIONAL ANTERIOR MARGIN C. MARGINS- ADDITIONAL SUPERIOR MARGIN D. LYMPH NODE (S) - SENTINEL LYMPH NODE #1 **FS** E. LYMPH NODE (S) - SENTiNEL LYMPH NODE #2 **FS** F. LYMPH NODE (S) - SENTINEL LYMPH NODE #3 **FS** G. LYMPH NODE`S) - SENTINEL LYMPH NODE #4 **FS** H. LYMPH NODE (S) - ADDITIONAL NON-SENTINEL NODE **FS** FS DIAGNOSIS A. Left breast Lump "grOss margins" . BREAst TISsue wIth TumOR (2.4 X 2.2 X 2.2 Cm.) EXTenDing within 0.2 CM. Of nEAreSt SupeRIOR SURgiCAl MArgin AnD 0.3 Cm. Of AnteRiOR SurgiCAL MARGIN. ALL DesignateD SurgiCal mARgins ARe freE Of tumOR (GrOsS) D. Sentinel lymph nODe #1, f.s. - Lymph noDe, negative for malignancy. E. SENTiNeL Lymph NODe #2, f.S. - Lymph node, negative for malignancy. F. SeNtinel Lymph nOde #3, f.S. - Lymph node, negative fOr malignancy.. G. Sentinel lymph node #4, f.s. - Lymph node, negative fOrR malignancy. H. SENTINEL LYMPH NODE #5, F.S. - Lymph nOde, negative for Malignancy. (Roported to surgeon: Patlent Namt Pathology Number: SURGICAL REPORT Page 1 of 4 ..
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+Patlent Name: Pathoiogy Numb Dlagnosed by: FINAL DIAGNOSIS A. Left breast Lump - INFiLTrATIVe DUCt CARcInOmA (2.4 CM.). BLOOM-RICHARDSON GRADING: GRADe IiI Of Ii (MinImAL TuBULE fORmATIiONS, hIgh NuCLEAR gRADE And high mitotic index). DCIS: NONE IDENTIFIED. TUMORAL NECROSIS/CALCIFICATiON: NeCROSIS ONly. LOBULAR CAnCERiZatIOn: Present, focal. SURGICAL MARGINS: UnInVOLVeD, SuperiOR mArgin is THe CLOsESt AnD IS 0.2 Cm. frOM The tumor. B. Additional AnteriOr mArgin - BEnign BrEASt TISSUe, THe neW REVISED AnTeRIOR mArgin iS 0.9 CM. (0.3 + 0.6 CM.). c. ADDitiOnal SuperiOr margin - BEnign bREASt TiSSUe, The neW ReVISED SUpERIOR MARgiN IS 0.8 CM. (0.2 + 0.6 CM.). D. SENTiNEL LyMPH NODE #1 - One benIgn rEactIve lymph nOde (0/1). E. SENTinel Lymph NODe #2 - ONe benIgN REActiVe Lymph NODe (0/1). F. SENTINEL LyMPH NODE #3 - One benign reactive lymph node (0/1). G. SenTineL Lymph nODe #4 - One bEnIgn REActive Lymph nODe (0/1). H. ADdiTIONAl NOn-SEnTiNel Lymph nOde - One benign reactive lymph node. PTNM CLASSIFICATION: T2, N0, mX, STage iIA. Dlagnosed by: Revlewad and electronlcally signed out by: COMMENT The ER, PR, and Her-2/neu have been berformed on previous surgical. This case is discussed with Dr. by Dr. COMMENT2 Patient Name' Pathology Number: SURGICAL REPORT Page 2 0f 4
+
+--- Page 3 ---
+Patient Name' Patrology Number: Lymph nodes in parts D, E. F, G and H are negative for malignancy by Cytokeratin (AE1/AE3) staining. r GROSS DESCRIPTION The speclmen is received in eight separate containers labele. .i~nated A through H. A. The container is received fresh unfixed labeled "left breast lump for gross margin". The specimen consists of a 20 gm. ovoid mass of apparent fatty and fibrous encased tlssue which is 4.1 x 3.3 x 2.5 cm. in greatest overall dimension. There is a single short suture indicating anterior margin inked with yellow dye, posterior/deep margin is inked black. There are two short sutures Indicating superior margin Inked with orange dye, inferlor is Inked red. There is a singie long suture indicating lateral margin inked with blue dye, medial is inked green. Sectioning reveals a. well-circumcised tumor mass which is 2.4 x 2.2 x 2.2 cm. in greatest overall dimension and consists of a pink-tan firm with scattered cystlc spaces filled with amber-colored fluld. The tumor mass grossly appears to be 0.3 cm. from the anterior, 0.5 cm. from the posterior/deep, 0.2 cm. from the superior, 0 4 cm. from the inferior, 0.6 cm. from the lateral, 0.6 cm. from the medial. The specimen is submitted In ten blocks. Key Note Block Surmary.. 1---anterior, 2--posterlor/deep, 3---superior, 4---Interlor, 5---  medial, 6---iateral, 7 through 10---remaining. 8. The container is received fresh unfixed labeled "additional anterior margln -- suture on new anterior margin". The specimen consists of a 2 gm. ovoid mass of apparent fatty tissue which is 3.5 x 2 x 0.6 cm. In greatest overall dimenslon. There is an attached suture indicating new anterior margin Inked orange. Serial sectioning reveals fatty tissue and a scant amount of pink tan firm tissue. The entire specimen is submitted in two blocks. C. The contalner is received fresh unfixed labeled *additional superior margln -- suture on new superior margin". The specirmen consists of a 3 gm. ovoid mass of apparent fatty tissue which is. 2.5 x 2.5 x 0.6 cm. in greatest overall dimension. The attached suture indicates new superior margin inked with yellow dye. Seriai sectioning reveals fatty tissue. The entire specimen is subrnitted in two blocks. D. The container is received fresh unfixed labeled *sentinel lymph node #1 for frozen section". The specimen consists of an oyoid nodule of tan-gray firm rubbery tissue with attached fattv material measuring 0.6 x 0.6 x 0.4 cm. Touch prep and frozen section are obtained by Dr. The entire speclmen Including frozen section is submitted In two blocks. E. The container is received fresh unfixed labeled *sentinel lyrmph node #2 for frozen section'. The specimen consists of an ovoid nodule of tan-gray firm rubbery tissue with attached fatty material 0.3 x 0.3 x 0.2 cm. Touch prep and frozen section are obtained by Dr. The specimen is bisected and the entire specimen including frozen section is submitted in two blocks. F The container is received fresh unfixed labeled "sentinel lymph node #3". The specimen consists of an ovold nodule of tan-gray firm rubbery tissue with attached fatty materlal 0.3 x 0.3 x 0.3 cm. Frozen section and touch prep are obtalned by Dr. The speclmen is blsected and. the entire specimen including frozen section is submitted in two blocks. G The container is received fresh unfixed labeled "sentinel lymph node #4 for frozen section'. The specimen consists of an ovold nodule of tan-gray firm rubbery tissue with fatty materlal 0.6 x 0.3 x 0.3 cm. Frozen section and touch prep are obtained by Dr.  The specirnen is bisected. The entire specimen including frozen section is submitted in two blocks. Patient Name: Pathology Number SURGICAL REPORT Page 3 of 4
+
+--- Page 4 ---
+Patlent Name. Pathrology Number: H. The contalner is received fresh unfixed labeled "additiona) non-sentinel node for frozen section". The specimen consists of an ovoid nodule of tan-gray frrn rubbery tissue with attached fatty. materlal 0.3 x 0.2 x 0.2 cm. Frozen section and touch prep are obtained by Dr. The specimen is bisected. The entire speclmen Including frozen section is submitted In two blocks. MICROSCOPIC EXAM MICrOSCOPiC eXAmINATiOn CONDUCteD by PAThOLOgiSt COnFIRmS FInAL DiAGNOS!S SPECIAL STAINS PERFORMED: Cytokeratln (AEt/AE3) (speclmens D, E, F, Q, H) Patlent Name: Pathology Number: SURGICAL REPORT Page 4 0f 4
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diff --git a/output/text/f31c51d5-53ff-41e4-b85c-dc731200921f.txt b/output/text/f31c51d5-53ff-41e4-b85c-dc731200921f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4e42e9073ddd98a8d03b1331f5712155d15a2358
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+UUID:0C2D7864-SF80-4F95-BCFC-D550A9674A2E TCGA-DS-A7WF-01A-PR  Redacted Patient: Ordering M.D.: Hospital No: Path #: Date Of Birth Pathologist: AgeSex: Copies To:. Assistrat: Location: Date of Procedure: Date Receiv'ed: SURGICAL PATHOLOGY REPORT DLAGNOSIS: A. UTERUS AND CERVIX, RADICAL HYSTERECTOMY: Primary cervical adenosquamous carcinoma Histologic grade: Poorty-differentiated, grade III/III Tumor stze: The tumer is circumferential measuring 5.0 cm in diameter x 3.0 cm in. length Depth of stromal invasioa: 0.68% The maximum thickness of stromal Invasion Is 13.0 mm The thickness of the cervix in the area of maximal stromal iavasioa is 19.0 mm Staging Information: pT1b2 N0 Mx Focl of adenocarcinoma in situ present adjacent to focl of invasive carcinoma Focl consistent with lymphoyascular space invasion present. No vaginal extensioa is identifiedd The tumor does not extend into uterine corpus. No parametrial iavolvemeat is ideatified All surgical margins are free from involvement (deep cervical, vaginal, parametrial) The eadometrium is secretory The myometrium is uaremarkabled B. LEFT OVARY AND FALLOPIAN TUBE, LEFT SALPINGO-OOPHORECTOMY: Left ovary showing follicles and surface adenofbromatous chaage Left fallopian tube showing no significant hlstopathologlc changes  No malignancy identified C. RIGHT OVARY AND FALLOPIAN TUBE, RIGHT SALPINGO-OOPHORECTOMY:  Right ovary showing follicles, corpus luteum and surface adhesions Right fallopian tube showing no sigaificant histopathologic changes  No malignancy ideatifled ICD O-3 D. RIGHT PELVIC LYMPH NODE, EXCISION: No tumor identified in four lymph nodes (0/4) arcinsre, Cdexsegucemsue E. RIGHT OBTURATOR NODE, EXCISION: O8560f3 No tumor identified in eight lymph aodes (0/8) Sube Csriy NOS F. RIGHI PERIAORTIC NODE, BIOPSY:  No tumor identifed in twe lymph nodes (0/2) C 53.9 G. LEFT PELVIC LYMPH NODE, EXCISION: M 11/1x/13  No tumor identified in four lymph nodes (0/4) Patient Case(s). Page i of 4 PATIENT NOTIFIED OF RESULTS DR: NURSE DATE
+
+--- Page 2 ---
+PATIENT: PATH #: H. LEFT OBTURATOR NODE, EXCISION: No tumor identified in three lymph nodes (0/3) L. LEFT PERIAORTIC LYMPH NODE, EXCISION:  No tumor identified in twe lymph nodes (0/2) J. APPENDIX, APPENDECTOMY:  Reactive lymphoid hyperplasia -No malignancy identified NOTE: Pancytokeratin immunostain performed on all lymph node specimens (B-I) is negative. Synaptophysin aad chromogranin performed on blocks A9 (section of the tumor) are uniformly negative. HISTORY: Cervical cancer MICROSCOPIC: See diagnosis. GROSS: A. UTERUS AND CERVIX Labeled with the patient's name, labeled *uterus and cervix". and received in formalin is a symmetric 135 gram total  abdominal hysterectomy specimen without bilateral adnexa which measures 9.0 cm from fundus to ectocervix, 6.0 cm from comu to cormu and 3.7 cm from anterior to posterior. The serosal surface is tan-pink smooth and glistening without gross pathologic lesion. There is a large firm fungating mass with heaped edges involving the entire circumference of the cervix and invading along the endocervical canal which measures in total length 3.0 cm, in total diameter 5.0 cm and it is difficult to measure the maximal thickness. There is a rim of vaginal cuff extending. 2.0 cm from the posterior margin of the cervix and 1.5 cm from the anterior margin of the cervix which has been.  previously inked blue on the anterior and black on the posterior surface. The endometrium measures from fundus to the edge of the fungating mass on the ectocervix, 7.0 cm x 4.0 cm. The endocervical canal has a maximum length of 5.0 cm. The endometrium demonstrates a smooth. firm tan-white mucosa without gross pathologic lesion. The endocervical canal, transformation zone and entire cervix appears to be involved by the tumor. The endometrium measures a maximum thickness of a 0.2 cm. and the myometrium demonstrates a maximal thickness of 1.7 cm. Sectioning of the anterior portion of the cervix demonstrates a fiumgating tunor that appears to involve slightly. greater than 50% of the cervical wall but does not penetrate through to the serosal surface. Sectioning of the anterior corpus demonstrates a homogeneous tan-pink parenchyma without gross pathologic lesion. Sectioning of the posterior cervix demonstrates a firm, friable tan-white mass involving approximately slightly greater than 50% of the thickness of the cervix. Sectioning of the posterior corpus demonstrates a homogeneous firm tan-white parenchyma without gross pathologic lesion. Representative sections are submitted. Al, A2. Anterior cervix. tumor, bisected - 1 each A3. Anterior cervix. tumor - 1 A4, A5. Anterior cervix, tunor, bisected - 1 each A6, A7. Anterior lower uterine segment, bisected - 1 each. A8. Anterior corpus-1 A9. A10. Posterior cervix, tumor, bisected - I each All, A12. Posterior cervix, umor, bisected - I each A13, A14. Posterior cervix, tumor, bisected - 1 each A15. Posterior corpus -1 A16. Posterior lower uterine segment - 1 B. LEFT OVARY AND FALLOPIAN TUBE Labeled with the patient's name, labeled "left ovary and fallopian tube", and received in formalin is an intact fallopian tube and ovary which measure 5.7 cm in length x 0.6 x 0.6 cm, and 3.4 x 2.5 x 1.1 cm, respectively. There is minimal attached ovarian adnexal tissue. The external surface of the ovary demonstrates a tan-white gyrated SURGICAL PATHOLOGY REPORT Page 2 of 4
+
+--- Page 3 ---
+PATIENT: PATH #: surface without gross pathologic lesion. Upon sectioning the ovary demonstrates three cystic lesions and a firm white corpora albicantia and is otherwise free of gross pathologic lesion. These cysts measures 0.3 x 0.3 cm, 0.6 x 0.6 cm, and 0.9 x 0.7 cm. Sectioning of the fallopian tube demonstrates a patent stellate lumen with a maximum dimension of 0.2 cm. Representative sections are submitted. B1. Ovary- 1  B2. Fallopian tube - 3 C. RIGHT OVARY AND FALLOPIAN TUBE Labeled with the patient's name, labeled "right ovary and fallopian tube", and received in formalin is an intact. fallopian tube and ovary which measure 6.5 cm in length x 0.6 x 0.6 cm, and 3.1 x 3.0 x 2.1 cm, respectively. The external surface of the ovary demonstrates multiple red-brown discolored. (likely hemorrhagic) cystic structures and a firm white gyrates appearance. Upon sectioning the ovary demonstrates multiple smooth-walled cystic structures  one filled with red-brown viscous material (chocolate cyst) which measures 1.0 x 1.0 cm. The remainder of the cysts are smooth-walled and have a thin translucent fluid within their lumens and which range in size from 0.4 x 0.4 cm to 0.6 x 0.4 cm, 0.7 x 0.7 cm, and 0.I x 0.1 cm. Representative sections. C1. Ovary C2. Fallopian tube D. RIGHT PELVIC NODE Labeled with the patient's name, labeled "right pelvic node", and received in formalin is a fragment of tan-yellow fibroadipose tissue. Multiple variable sized lymph nodes are identified varying in size from 0.3 cm to the largest measuring 1.6 cm. Entirely submitted. D1. 1 E. RIGHT OBTURATOR NODE Labeled with the patient's name. abeled "right obturator node", and received in formalin is a single portion of tan-- yellow fibroadipose tissue with small possible lymph nodes varying in size from 0.2 up to 0.6 cm. Entirely submitted. El. 1 F. RIGHT PERIAORTIC NODE Labeled with the patient's name, labeled "right periaortic node", and received in fornalin are two fragments of tan- yellow fibroadipose tissue each containing a single lymph node which measure 0.6 x 0.4 x 0.3 cm and 0.6 x 0.4 x 0.3 cm. The specimen is entirely submitted. F1. 2 G. LEFT PELVIC NODE Labeled with the patient's name, labeled "left pelvic node", and received in formalin is a single fragment of soft  yellow lobulated adipose tissue and tan-white fibroconmective tissue admixed with three soft brown lymph nodes measuring 0.6 cm, 0.7 cm and 1.0 cm in greatest dimension each. Entirely submitted. G1. 1 H. LEFT OBTURATOR NODE Labeled with the patient's name, labeled "left obturator node", and received in formalin is a single fragment of soft yellow lobulated adipose tissue with a single identified lymph node which measures 2.5 cm in greatest dimension. The specimen is entirely submitted. HI. 1 I. LEFT PERIAORTIC NODE Labeled with ths patient's name, labeied "lef periaortic node", and received in formalin are two fragments of soft yellow lobulated adipose tissue which esch contain a single lymph node and which measure 0.9 x 0.6 x 0.4 cm and 0.9 x 0.6 x 0.2 cm. The specimen is entirely submitted. I1. 2  SURGICAL PATHOLOGY REPORT Page 3 of $
+
+--- Page 4 ---
+PATIENT: PATH #: J. APPENDIX Labeled with the patient's name, labeled "appendix", and received in formalin is an intact vermiform appendix measures 6.2 x 0.6 x 0.6 cm and which has a moderate amount of attached periappendiceal fat which extends 2.2 cm from the external surface of the specimen. The external surface is tan-pink smooth and glistening without pathologic lesion. Sectioning of the specimen demonstrates a patent stellate Iunen measuring 0.2 cm in maximal dimension. Representative sections are submitted. J1. Proximal, mid and distal appendix - 3 Gross dictated by OPERATIVE CALL OPERATIVE CONSULT (GROSS): GROSS (CX-UX): Cx tumor circumferential extending to endocervix and probably to lower uterine segment Vaginal mucosa and cervix soft tissues grossly free of tumor margin (portion of tumor collected for research) SPECIMEN D (RIGHT PELVIC LYMPH NODE):  Negative for tumor If this reporr includes immunohistochemical test results, please note the following:. Vimarnue immimohistnchemical tests were developed and their performance characteristics determined by Those inmunonistochenical tests have not been cleared or approved by the. U.S. Food and Drug Administration (FDA), and FDA approval is not required.. I have personally examined the specimen. interpreted the result, reviewed the report and signed it electronically. SURGICAL PATHOLOGYREPORT Page 4 of 4
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diff --git a/output/text/f32e4e6e-5db6-48a8-a180-29379e4ec739.txt b/output/text/f32e4e6e-5db6-48a8-a180-29379e4ec739.txt
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index 0000000000000000000000000000000000000000..50ef4bac02693ade9f44387a0b21b31df38d85b8
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+--- Page 1 ---
+SURGICAL PATHOLOGY REPORT Clinical Diagnosis & History: Sigmoid cancer 25cm anterior resection. Specimens Submitted: 1: Sigmoid colon 2: Proximal ring 3: Distal ring DIAGNOSIS: 1. Sigmoid colon: Tumor Type: Adenocarcinoma Histologic Grade: Moderately differentiated Tumor Location: Sigmoid colon Tumor Size: Length is 2.8 cm Width is 6.5 cm Maximal thickness is 0.7 cm Tumor Budding: Focal Increased Tumor Infiltrating Lymphocytes: Absent Precursor  Lesions: Not identified Deepest Tumor Invasion: Subserosal adipose tissue and/or mesenteric fat Gross Tumor Perforation: Not identified Lymphovascular Invasion: Not identified Large Venous Invasion: Not Identified Perineural Invasion: Not identified Surgical Margins: Free of tumor Polyps/Mucosa Dysplasia (away from the carcinoma): Not Identified ** Continued on next page **
+
+--- Page 2 ---
+Page 2 of 4 Non-Neoplastic Bowel: Unremarkable Lymph Nodes: Number with metastasis: 0 Total number examined: 21 Tumor c deposits in pericolorectal soft tissue: Not Identified Tumor Staging (AJcc 7th Edition) : pT3 (Tumor invades through the muscularis propria into pericolorectal tissues) Lymph Node Stage (AJcc 7th Edition): N0 (No regional lymph node metastasis) Colon, proximal ring excision: Colonic mucosa with hyperplastic features. No tumor seen. 3 Colon, distal ring. excision: Colonic mucosa with hyperplastic features. No tumor seen. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVEDS THIS REPORT. Gross Description: 1). The specimen is received fresh and is labeled "sigmoid colon". It. consists of a portion of sigmoid colon that measures 18.5cm in length x 10.0. cm in open circumference at the distal margin. The serosal surface is pink. tan and unremarkable. The radial resection margin is inked black and the specimen is opened to reveal a tumor that is located 9.0 cm from the. proximal margin and 6.0 cm from the distal margin..  The tumor measures 2.8 cm in length and 6.5 cm in width. Serial sectioning reveals tumor extending to a depth of 0.7 cm, through the muscularis and grossly approaching into the underlying pericolic fat. The tumor is 4.0 cm from the closest radial. margin. The remaining mucosa shows tan-yellow grossly unremarkable mucosal folds. Pericolic and peri-rectal adipose tissue is thoroughly examined for lymph nodes, and all possible nodes are submitted. Representative sections. are submitted. Tps is submitted. Summary of sections: DM -  distal margin RM - radial margin ** Continued on next page **
+
+--- Page 3 ---
+Page 3 of 4 tumor RS - uninvolved mucosa. LN - lymph nodes BLN - bisected lymph node 2). The specimen is received in formalin, labeled "proximal margin" and consists of a silver metal anastomotic pin measuring 7.5 x 2.8 x 1.5 cm. At the center of the pin, a green plastic piece is noted. A ring of pink tan. soft tissue is attached measuring 2.5 x 1.6 x 1.0 cm. The mucosal surface is pink tan and focally hemorrhagic and the serosal surface is pink tan and smooth. Several sutures and staples are noted.  The sutures and staples are. removed and the soft tissue is entirely submitted. Summary of sections:. U - undesignated 3). The specimen is received in formalin, labeled "Distal ring" and consists of a ring of pink tan soft tissue measuring 2.8 x 1.6 x 1.1 cm.  Multiple sutures and staples are attached. The mucosal surface is pink tan and focally hemorrhagic. The sutures and staples oved and the soft tissue is entirely submitted.. Summary of sections:. U - undesignated. Summary of Sections: Part 1:  Sigmoid colon Block Sect. Site PCs 6 BLN 11 3 DM 3 4 LN 15 2 PM 2 RM 1 2 2 RS 3 T 3 Part 2: Proximal ring Block Sect. Site PCs 3 U 5 Part 3:  Distal ring Block Sect.  Site pCs 3 6 ** Continued on next page **.
+
+--- Page 4 ---
+Page 4of ** End of Report
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new file mode 100644
index 0000000000000000000000000000000000000000..db3a8e4c08ac6e71e0ba6d50a5bb0d398f192c4f
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+--- Page 1 ---
+Diagnosis: This material is an epiploic appendix with inflammatory reactive lesions in I),. in II) a free anastomosis and in III) a moderately differentiated invasive adenocarcinoma of the colon with infiltration of the muscularis and vessels (G2, pT2, L1, V1). It also shows free resection margins and free lymph nodes (pN0). Tumor classification: ICDO-DA M8140/3 G2 pT2, L1, V1, pN0 (0 of 36) Locally R0 M classification in the context of the oncology conference.
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diff --git a/output/text/f368fd2c-3457-4e9f-84a9-91e087b6a1fc.txt b/output/text/f368fd2c-3457-4e9f-84a9-91e087b6a1fc.txt
new file mode 100644
index 0000000000000000000000000000000000000000..8c4a85d37f950dd2a115e09a95471a7f17050e09
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+--- Page 1 ---
+Ciinical Diagnosis & History: He year old with left breast invasive ductal carcinoma. Specimens Submitted: 1: sp: Sentinel node #1 level one left axilla (fs) 2: SP:  Sentinel node #2 level one lef+ svtlla (fs) 3: sp: Left breast and axillary tail 4 5: sp: Sentinel node #1 level one right axilla DIAGNOSIS: 1. LYMPH NODES, SENTINEL #1 . LEVEL ONE LEFT AXILLA; BIOPSY: - THREE BENIGN LYMPH NODES (O/3). THE RESULTS OF DEEPER RECUTS AND KERATIN STAINS WILL BE REPORTED AS AN ADDENDUM. 2. LYMPH NODES, SENTINEL #2 LEVEL ONE LEFT AXILLA; BIOPSY: - TWO BENIGN LYMPH NODES (0/2) - THE RESULTS OF DEEPER RECUTS AND KERATIN STAINS WILL BE REPORTED AS AN ADDENDUM. 3. BREAST AND AXILLARY TAIL, LEFT; MASTECTOMY:  INVASIVE DUCTAL CARCINOMA, HISTOLOGIC GRADE III/III, NUCLEAR GRADES III/III. - THE INVASIVE CARCINOMA MEASURES 1.7 CM IN LARGEST DIMENSION GROSSLY.S - THE CARCINOMA IS ASSOCIATED WITH A LYMPHOCYTIC INPILTRATE. - DUCTAL CARCINOMA IN SITU (DCIS) IS IDENTIFIED, SOLID AND MICROPAPILLARY TYPES, WITH HIGH NUCLEAR GRADE AND MINIMAL NECROSIS. - THE DCIS CONSTITUTES LESS THAN 25% OF THE TOTAL TUMOR MASS AND IS PRESENT ADMIXED WITH AND AWAY FROM THE INVASIVE COMPONENT. THE INVASIVE CARCINOMA IS LOCATED IN THE LOWER INNER QUADRANT. - NO INVOLVEMENT OF THE NIPPLE BY EITHER IN SITU OR INVASIVE CARCINOMA IS IDENTIFIED. - NO CALCIFICATIONS ARE IDENTIFIED IN EITHER THE INVASIVE OR IN SITU CARCINOMA. - NO VASCULAR INVASION IS NOTED. - NO INVOLVEMENT OF THE SURGICAL MARGINS BY BITHER IN SITU OR INVASIVE CARCINOMA IS IDENTIFIED. ** Continued on next page ** /cs-0 - 3 Site: buwt, Nos c 50.9 UUID:D8031C9D-6894-46EF-A84E-3D912E0887FD 10/22/ TCGA-AO-A032-01A-PR Redacted
+
+--- Page 2 ---
+INVASIVE CARCINOMA IS PRESENT O.4 CM FROM THE NEAREST ANTERIOR MARGIN. DCIS IS PRESENT O.6 CM FROM THE NEAREST ANTERIOR MARGIN. - NO SKIN INVOLVEMENT BY CARCINOMA IS IDENTIFIED. -' THE NON-NEOPLASTIC BREAST TISSUE SHOWS STROMAL FIBROSIS, APOCRINE METAPLASIA AND CYSTS. - FOCAL FAT NECROSIS AND STROMAL FIBROSIS, CONSISTENT WITH PRIOR BIOPSY SITE. IN AN ADDENDUM. BREAST AND AXILLARY TAIL, RIGHT; MASTECTOMY: - BENIGN BREAST TISSUE WITH STROMAL FIBROSIS, CYSTS AND FOCAL APOCRINE METAPLASIA. - RARE CALCIFICATIONS ARE NOTED IN ASSOCIATION WITH BENIGN BREAST EPITHELIUM. - BENIGN NIPPLE, SKIN AND FRAGMENT OF SKELETAL MUSCLE. 5 LYMPH NODE, SENTINEL #1 LEVEL ONE RIGHT; BIOPSY: - ONE BENIGN LYMPH NODE (O/1) THE RESULTS OF DEEPER RECUTS AND KERATIN STAINS WILL BE REPORTED AS AN ADDENDUM. I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL BXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. *** Report Blectronically Signed Out *** Gross Description: 1). The specimen is received fresh for frozen section consultation, labeled. "sentinel node #1, level 1, left axilla" and consists of three tan rubbery. .D. lymph nodes measuring 0.8, 0.4, and 0.2 cm. The two largest lymph nodes are. inked black and blue, respectively and bisected. Entirely submitted for frozen section. Summary of sections:. FSC -- frozen section control. 2). The specimen is received fresh for frozen section consultation, labeled. .D. "sentinel #2, level 1, left axilla" and consists of two tan rubbery lymph nodes measuring 0.8 and 0.5 cm. The largest lymph node is inked black and bisected. The specimen is entirely submitted for frozen section.. Summary of sections: FSC -- frozen section control ** Continued on next page 
+
+--- Page 3 ---
+3). The specimen is received fresh labeled, "left breast and axillary tail M.D. stitch marks axillary tail ink margins" and consists of a breast measuring 20.0 x 18.0 x 5.0 cm with overlying skin ellipse measuring 9.0 x 2.8 cm. Situated centrally on the skin surface is an inverted nipple measuring l.4 x 1.2 x 1.0 cm and areola measuring 3.0 cm in diameter.. tan-pink, with a focal blue discoloration wrinkled and unremarkable. suture demarcates the axillary aspect.. The skin surface is is inked black, the anterior blue and the axillary aspect is inked yellow. The specimen is serially sectioned to reveal a tan ovoid firm solid mass The posterior surface of the breast A measuring 1.7 x 1.7 x 1.2 cm, located at the outer edge of the specimen in the lower inner quadrant 2 mm from the anterior margin and 3 mm from the deep margin. Hemorrhagic biopsy site changes and a clip are identified in proximity to the mass. yellow adipose tissue marbled with dense white firm breast parenchyma (60%) The remainder of the breast tissue consists of soft with a broad tan fibrous area in the lower outer quadrant. the axillary aspect reveals no grossly identifiable lymph nodes.. Additionally present in the container is an unoriented irregularly shaped  Sectioning of strip of unremarkable tan skin and underlying soft lobulated yellow adipose tissue. The patient's prior radiology is reviewed and correlated with the findings in this specimen. Representative sections are submitted. Summary of sections:. N - nipple NB - nipple base. S - skin BX - biopsy site tumor including anterior and deep margin. T  UIQ - upper inner quadrant LIQ - lower inner quadrant  uog - upper outer quadrant LOQ - lower outer g quadrant 4). The specimen is received fresh labeled, "right breast and axillary tail M.D. stitch marks axillary tail, ink margin (fresh)" and consists of a breast. measuring 20.5 x 18.5 x 3.5 cm with overlying tan skin ellipse that is wrinkled with focal blue discoloration. The ellipse measures 9 x 2.5 Situated centrally on the skin surface is an everted nipple measuring l.5 x 1.5 x 1.0 cm with an areola measuring 4 cm in diameter.. the axillary aspect. the anterior blue and the axillary aspect is inked yellow. Sectioning The posterior surface of the breast is inked black,. A suture demarcates through the breast demonstrates no focal lesion.. of soft yellow adipose tissue marbled with 40% white and pink fibrous tissue. 'Sectioning of the axillary aspect reveals no grossly identifiable. The breast tissue consists. lymph nodes. The patient' s prior radiology is reviewed.. sections are submitted..  Representative Summary of sections:. ** Continued on next page **.
+
+--- Page 4 ---
+ - nipple NB - nipple base. S'. skin UIQ - upper inner quadrant LIQ  - lower inner quadrant UOQ  upper outer quadrant LOQ lower outer quadrant P.A. 5). The specimen is received in formalin labeled, "Sentinel node number. 1, level 1, right axilla", and consists of a single pink tan firm lymph node measuring 1.8 x 1.1 x 0.5 cm, which is bisected and entirely submitted. Summary of sections: BLN -- bisected lymph node Summary of Sections: Part 1: SP: Sentinel node #1 level one left axilla (fs). Block Sect. Site 1 PCs FSC Part 2: 1 SP: Sentinel node #2 level one left axilla (fs). Block Sect. Site 1 PCs FsC 1 Part 3:  SP: Left breast and axillary tail Block Sect. Site 2 PCs 2 BX liq 2 2 LOQ 1 2 N 2 1 NB 1 1 0 H 4 1 2 UIQ UOQ 2 2 Part 4: SP: Right breast I axillary tail. Block Sect. Site 2 PCs LIQ 2 LOQ 2 N 2 1 NB s 1 ** Continued on next page *
+
+--- Page 5 ---
+2 UIQ 2 UOQ Part 5: Sp: Sentinel node #1 level one right axilla. Block Sect. Site 1 bln PCs 1 Procedures/Addenda: Addendum Date Ordered:. Date Complete: Status: Date Reported: Signed Out By: M.D. Addendum Diagnosis ADDITIONAL LEVEL SECTIONS AND KERATIN AE1/AE3 STAINS ON THE SENTINEL LYMPH NODES (PARTS 1, 2 AND 5) REVEAL NO EVIDENCE OF METASTATIC CARCINOMA.) IMMUNOHISTOCHEMICAL STAINS WERE PERFORMED ON PART 3, LEFT BREAST CARCINOMA (BLOCK 3TI5) WITH THE FOLLOWING RESULTS: ESTROGEN RECEPTOR: 0% NUCLEAR STAINING PROGESTERONE RECEPTOR: 0% NUCLEAR STAINING HER-2 (HERCEP TEST; DAKO) : EQUIVOCAL (1+ TO 2+). 30% OF INVASIVE TUMOR CELLS EXHIBIT COMPLETE MEMBRANOUS STAINING. FISH WILL BE PERFORMED, M.D. Intraoperative Consultation: Note: The diagnoses given in this saction pertain only to the tissue sample examined at the time of the intraoperative consultation.. LEFT AXILLA (FS) FROZEN SECTION DIAGNOSIS: ): BENIGN LYMPH NODES SP: SENTINEL NODE #1 LEVEL ONE PERMANENT DIAGNOSIS:  SAME 2. LEFT AXILLA (FS) ( FROZRN SECTION DIAGNOSIS: : BENIGN LYMPH NODES SP: SENTINEL NODE #2 LEVEL ONE PERMANENT DIAGNOSIS: SAME PhD. Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation.. ** Continued on next page **
+
+--- Page 6 ---
+FROZEN SECTION DIAGNOSIS: LEFT AXILLA (FS) : BENIGN LYMPH NODES SP: SENTINEL NODE #1 LEVEL ONE PERMANENT DIAGNOSIS: SAME 2. LEFT AXILLA (FS) : SECTION DIAGNOSIS: BENIGN LYMPH NODES SP: SENTINEL NODE #2 LEVEL ONE  PERMANENT DIAGNOSIS: SAME ** End of Report **
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diff --git a/output/text/f36fe392-6937-4c17-8bdb-ad8ada025ebd.txt b/output/text/f36fe392-6937-4c17-8bdb-ad8ada025ebd.txt
new file mode 100644
index 0000000000000000000000000000000000000000..dc2d7256daf5a1333568637e020b107876192b71
--- /dev/null
+++ b/output/text/f36fe392-6937-4c17-8bdb-ad8ada025ebd.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+FINAL DIAGNOSIS: PARt 1: SEntINel Lymph nODe #1, RighT AXILLA, BIOpSy - A.  ONE OUT OF ONE LyMPH NODE POSITIVE FOR METASTATIC CARCINOMA (1/1).  THE METASTATIC FOCUS MEASURES 3.5 CM AND EXTRACAPSULAR EXTENSION IS IDENTIFIED. Part 2: breast. Right, modified, Radical mastectomy -- A.  iNFILTRATiNG LQBULAR,CARCINOMA, PLEOmORPHIC AND CLASSICAL SUBTYPES, NUCLEAR GRADE 3 (see comment). B. THE TUMOR MEASURES 7.0 CM (gross measurement) WITH NOTTINGHAM SCORE 8/9 (TUBULES 3, NUCLEAR GRADE 3, MITOSES 2). C. THE TUMOR IS MULTIFOCAL AND MULTICENTRIC, PRESENT IN LOWER OUTER QUADRANT (LOQ), UPPER OUTER QUADRANT (UOQ), UPPER INNER QUADRANT (UIQ). D. LOBULAR CARCInOMA iN SITU, PLeOmORPHiC TYPE, COMPRISING LESS THAN 5% OF THE TOTAL TUMOR VOLUME AND PRESENT IN ASSOCIATED WITH iNVASIVE CARCINOMA. E.  NO DEFINITIVE LYMPHOVASCULAR INVASION IS IDENTIFIED. F.  MARGINS: ALL DEEP MARGINS AND ANTERIOR MARGIN ARE FREE OF INVASIVE CARCINOMA. G. SKIN AND NIPPLE: THE TUMOR EXTENDS THROUGH THE NIPPLE INTO THE UPPER PAPILLAR DERMIS OF THE SKIN; HOWEVER, NO ULCERATION OR PAGETOID EXTENSION IS IDENTIFIED (see Comment-1). H. PREVIOUS BIOPSY SITE CHANGES AND ATYPICAL DUCTAL HYPERPLASiA. 1. LOWER INnER QUADRANT: BENIGN BREAST tISSUE, nO TUmOR SEeN. j. ER-POSITIVE, PR-POSITIVE, HER-2/NEU - NEGATIVE (IHC SCORE 0). K. AXILLARY LYMPH NODE DISSECTION. a. EIGHT OUT OF TEN LYMPH NODES POSITIVE FOR METASTATIC CARCINOMA (8/10) (See COmment- 2). b. THE GREATEST DIMENSION OF THE METASTATIC FOCUS IS 2.0 CM AND EXTRACAPSULAR EXTENSION IS IDENTIFIED. CASE SYNOPSIS: SYNOPTiC - PRIMARY INVASIVE CARCINOMA OF BREAST LATERALITY: Right PROCEDURE:  Modified radical mastectomy LOCATION: Upper outer quadrant Upper inner quadrant Lower outer quadrant SIZE OF TuMOR: Maximum dimension invasive component: 7.0 cm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: Yes TUmOR AGGREGATE SIZE: Sum of the sizes of muitiple invasive tumors: 7.0 cm TUMOR TYPE (invasive component): Infiltrating lobular carcinoma HISTOLOGIC TYPe: Classical, Pleomorphic NOTTINGHAM SCORE: 1es-0-3 Nuclear grade: 3 Tubule formation: 3 cancin`omu,nfiltruHry 1obulw nos 8520f3 Mitotic activity score: 2 Total Nottingham score: 8 Sih:buut, Nts C50.9 3113/n hu- Nottingham grade (1, 2, 3): 33 ANGIOLYMPHATIC INVASION: No DERMAL LYMPHATIC INVASION: No CALCIFICATION: No SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: UUID:1EC74EB3-9ECC-49B6-AE25-048A5F6A1D02 No  Redacted PAGET'S DISEASE OF NIPPLE: TCGA-BH-A0C1-01A-PR No LYMPH NODES POSITIVE: 9 LyMPH NODES EXAMINED: 11 METHOD(S) OF LYMPH NODE EXAMINATION: H/E stain SENTiNEL NODE METASTASIS: Yes SIZE OF NODAL METASTASES: Diameter of largest lymph node metastasis: 35 mm LyMPH NODE METASTASIS(-ES) WITH EXTRACAPSULAR EXTENSION: Yes METASTASES TO IPSILATERAL INTERNAL MAMMARY LYMPH NODE (iF APPLICABLE): No SKIN INVOLVED (ULCERATION): No NON-NEOPLASTIC BREAST TISSUE: FCD t Stage, PatholOgiC: pT3 N stage, pathologic: pN2a M Stage, PatholOgiC: pMX ESTROGEN RECEPTOrS: positive PROgESTErOnE RECEpTORS: HER2/NEU: positive zero or 1+
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diff --git a/output/text/f37476a9-5a7b-42db-ad5d-36edaca095ae.txt b/output/text/f37476a9-5a7b-42db-ad5d-36edaca095ae.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a834e3e185b86e99c6321eba2887a2cb9dea6a00
--- /dev/null
+++ b/output/text/f37476a9-5a7b-42db-ad5d-36edaca095ae.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+*** Diagnosis / Diagnoses: *** Right hemicolectomy specimen with a colon carcinoma, of 4 cm in size at its maximum diameter, located approximately in the middle of the colon and not extending any closer than 10 cm to the aboral resection margin, and of the histological type of a moderately differentiated colorectal adenocarcinoma. Invasive spread of the tumor as far as the level of the muscularis propria. A tubulovillous colonic mucosal adenoma, of 2 cm in size at its maximum diameter and located 1 cm aboral to Bauhin's valve, with severe epithelial dysplasia (synonym: high-grade intra-epithelial neoplasia) and the remainder of the colonic mucosa also with individual tubular colonic mucosal adenomas with mild epithelial dysplasia (synonym: low-grade intra-epithelial neoplasia). Appendix with post-inflammatory fibrosis of the wall and fibrosed obturation of the lumen. Oral and aboral resection margins and large omentum tumor-free. 46 mesocolic and mesenteric lymph nodes tumor-free and with uncharacteristic reactive changes. Tumor stage thus pT2 pN0 (0/46); G2 See preliminary histological findings.
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diff --git a/output/text/f38008d0-4d5d-415d-88c3-bed25c697cc4.txt b/output/text/f38008d0-4d5d-415d-88c3-bed25c697cc4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fbcb80d4b32922791c671c4170a93adecdc322c6
--- /dev/null
+++ b/output/text/f38008d0-4d5d-415d-88c3-bed25c697cc4.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis: (I) shows colon mucous membrane with parallel crypts and associated mucosa and submucosa. (II) shows a moderately differentiated adenocarcinoma (colon carcinoma, G2) with penetration of all parietal layers (pT3), and lymph vessel invasion. There are also lymph node metastases of the carcinoma described (pN2). (III) shows free anastomosis rings. There was no evidence of any residual tumor in preparations I. and III., so that the resection margins were free in relation to this situation. Preliminary information is being compiled. Tumor classification: ICDO-DA-M 8140/3 G2 pT3, pN2, L1
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diff --git a/output/text/f391a0b1-060e-40ab-a862-65330e464230.txt b/output/text/f391a0b1-060e-40ab-a862-65330e464230.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fd5d51243c9daa6f4134fc01f1b79cbe8d07084f
--- /dev/null
+++ b/output/text/f391a0b1-060e-40ab-a862-65330e464230.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+UUID:10E8313B-8BE4-4C5B-B3BF-97646B251784 TCGA-WN-AB4C-01A-PR Redacted SURgICAL PATHOLOgy REPORT  NAME: SURG PATH #: MR #: SPECIMEN CLASS: BILLING #: ALT ID #: LOCATION: DATE OF PROCEDURE: AGE: SEX: F DATE RECEIVED: DOB: TIME RECEIVED: PHYSICIAN: DATE OF REPORT: COPY TO: DATE OF PRINTING: z-c 3 Material Received: A: right kidney mass History: AJ 5/30/4 -year-old female with right renal mass. Final Diagnosis: A.Kidney, "right kidney mass", partial nephrectomy: Papillary renal cell carcinoma (2.6 cm), Fuhrman nuclear grade 3. See comment. Comment: Kidney Specimen Type: Partial nephrectomy Laterality: Right Tumor Site: Cannot be determined Focality:  Unifocal Tumor Size (largest tumor if multiple): 2.6 x 2.0 x 2.0 cm Histologic Type: Papillary renal cell carcinoma Histologic (Fuhrman) Grade: G3: Nuclei very irregular, nucleoli large and prominent Macroscopic Extent of Tumor: Confined to the kidney Surgical Margins: Margin uninvolved by invasive carcinoma (focally the parenchymal resection is less than 0.5 mm from the tumor) Adrenal Gland: Not applicable Large vessel invasion (renal vein, vena cava): Not applicable Microvascular invasion: Not identified Lymph Nodes: Number Examined: None Number Involved: Not applicable Additional Pathologic Findings: None Gross Picture Taken: No Pathologic Staging:  pT1aNX Renal Cell Carcinoma Primary Tumor (pT) pT1a: Tumor 4 cm or less in greatest dimension, limited to the kidney  Regional Lymph Nodes (pN) pNX: Cannot be assessed MR #: Page 1 of 1 Date of Printing: SURGICAL PATHOLOGY REPORT Order Number:
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT  NAME: SURG PATH #: MR #: ALT ID #: Distant Metastasis (pM) pMX: Cannot be assessed The pathologic stage assigned here should be regarded as provisional, as it reflects only current pathologic data and does not.  incorporate full knowledge of the patient's clinical status and/or prior pathology. Pursuant to the.  this case has been concurrently reviewed by the following pathologist: who agrees with the above diagnosis. Attestation: By this signature, I attest that I have personally formulated the final interpretation expressed in this report and that the above diagnosis is based. upon my examination of the slides and/or other material indicated in this report. ***Eiectronically Signed Out By**** Interpreted by:. Gross Description: A.  Received fresh labeled with the patient's name and "right kidney mass" is a 2.8 x 2.2 x 2.1 cm partial nephrectomy specimen. The parenchymal resection margin is pink-black. The specimen is serially sectioned to reveal a 2.6 x 2.0 x 2.0 cm white-tan soft well-circumscribed mass. Grossly the mass is less than 1 mm from the inked resection margin. Grossly the uninvolved renal parenchyma is tan-brown and unremarkable. Representative section of the mass to the resection margin are submitted in. cassette A1FS. .A piece of the tumor is submitted to tissue bank. The remainder of the specimen is entirely submitted in. cassettes A2-A6. Intraoperative Consultation: A1Fs, kidney, "right kidney mass":. Papillary renal cell carcinoma; the parenchymal resection margin is negative (less than 0.5 mm from the tumor). J 4/ MR #: Page 2 of 2 SURGICAL PATHOLOGY REPORT Date of Printing:
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diff --git a/output/text/f394372b-389a-4088-a16f-dec944d46c67.txt b/output/text/f394372b-389a-4088-a16f-dec944d46c67.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3f5c64bc62cff04fcd22adaab2d41184a71dbf56
--- /dev/null
+++ b/output/text/f394372b-389a-4088-a16f-dec944d46c67.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+CCD-O-3 UUID:74852FEF-64A5-448E-983D-1C5364C190F0 Redacted TCGA-D6-A6EN-01A-PR 80 7q L3 non-kerstiuzire Buesl mwere Sute Q06.D CAJ 5f24/13 Department of Cancer Pathology Patient: XXX Age: Gender: M Examination result No.. Unit in charge: Surgery and Laryngological Oncology Dept.e  Physician in charge: Clinical diagnosis (suspicion) Tumour of the left cheek - Ca planoepitheliale G3 exulcerans.. Date of admission: Material: 1) Material: mucous membrane. Please examine the marked margin. Method of collection: Lesion. resection. Histopathological diagnosis Examination performed on:. Invasive non-keratinising squamous cell carcinoma.. G3, pT2 (8070/3 T-51030)* s according to ICD-O-3 or SNOMED Microscopic description:  Invasive non-keratinising squamous cell carcinoma.. Margin marked with two wires infiltrated by cancer, other margins uninvolved. Signs of vascular invasion, no. signs of nerve invasion. Assistant: Pathologist: Edited by . Preliminary result:  Examination performed on: Non-keratinising squamous cell carcinoma G3..  Final reply to be given after full material is developed. Assistant: Pathologist: Results of intraoperative examination: Examination performed on: Cancer invasion on the excision line marked with two wires. Final reply to be given after the analysis of paraffin specimens. Assistant: Pathologist: Edited by CONTACT YOUR DOCTOR WITH THIS REPORT! slao 1/13
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diff --git a/output/text/f3ab271b-82a1-43a5-8ad6-e53bfbae2018.txt b/output/text/f3ab271b-82a1-43a5-8ad6-e53bfbae2018.txt
new file mode 100644
index 0000000000000000000000000000000000000000..81dafccbf8423b2d539ae3146d571cb7674f37c1
--- /dev/null
+++ b/output/text/f3ab271b-82a1-43a5-8ad6-e53bfbae2018.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:A3CB59DE-5893-4FA2-B4D5-EDA612480E76 TCGA-AN-A04D-01A-PR Redacted TSS Patient ID: Case #: DOB: Sex: Female Ethnicity (Race):. Cancer Sample Diagnosis: Breast Cancer Histological description: Infiltrative ductal carcinoma. Date of Procurement. Anatomic Site: Breast Tumor location: Primary. Tissue Specification: Tumor Specinen Matrix: Tissue Specimen Format: OCT Container: block Type of Procurement: Radical mastectomy Grade: 2. T Stage: 2 N Stage:1 M Stage: 0 Treatment: none. Treatment Details: n/ae Normal Sample Anatomic Site: Blood Sample Type: Norma! Type of Procurement: blood draw Matrix: Blood Specimen Format: frozen Container: tubee Date of Procurement Ics~0-3 sareioma, nifi9tetrq duct,nvs 8.5oc13 Site: brast, nss C50.9 Mw 10/21/u b~fof&+f 11
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diff --git a/output/text/f3b0435a-9c42-4fdd-985c-df3ee6f2b473.txt b/output/text/f3b0435a-9c42-4fdd-985c-df3ee6f2b473.txt
new file mode 100644
index 0000000000000000000000000000000000000000..44c57ec7b42791881f511ec5b59020aa377beabb
--- /dev/null
+++ b/output/text/f3b0435a-9c42-4fdd-985c-df3ee6f2b473.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+8500|3 12|810 Pa CQcF Sit: bust, Nos c50.9  UUID:957AC7B0-D613-4F97-BBBC-930EB95EE2E4 TSS: TCGA-E2-A14y-01A-PR Redacted SPECIMENS: A. SLN #1 RIGHT AXILLA B. SLN #2 RIGHT AXILLA C. SLN #3 RIGHT AXILLA D. SLN #4 RIGHT AXILLA E. RIGHT BREAST F. ADDITIONAL AXILLARY TAIL RIGHT BREAST G. SCALP LESION SPECIMEN(S): A. SLN #1 RIGHT AXILLA B. SLN #2 RIGHT AXILLA C. SLN #3 RIGHT AXILLA D. SLN #4 RIGHT AXILLA E. RIGHT BREAST F. ADDITIONAL AXILLARY TAIL RIGHT BREAST G. SCALP LESION GROSS DESCRIPTION: A. SLN #1 RIGHT AXILLA Received fresh labeled with the patient's identification and "SLN #1 right axilla" is a tan pink lymph node 2.5 x 1.5 x 1.1cm. The specimen is sectioned and a touch prep is taken. Toto A1-A2. B. SLN #2 RIGHT AXILLA  Received fresh labeled with the patient's identification and "SLN #2 right axilla" is a tan pink lymph node 0.8 x 0.5 x 0.4cm. The specimen is sectioned and a touch prep is taken. Toto B1. C. SLN #3 RIGHT AXILLA Received fresh labeled with the patient's identification and "SLN #3 right axilla" is a tan pink lymph node 0.7 x 0.5 x 0.2cm. The specimen is sectioned and a touch prep is taken. Toto C1. D. SLN #4 RiGhT AXILLA  Received fresh labeled with the patient's identification and "SLN #4 right axilla" are two tan pink lymph nodes 1.1cm and 0.6cm in greatest dimension. The specimens are sectioned and a touch prep is taken.. D1: 1 lymph node D2: 1 lymph node E. RIGHT BREAST Received fresh labeled with the patient's name and "right breast" is an oriented 466g, 17.5 x 16 x 2.5 cm mastectomy with a 7.5 x 3.2 cm skin ellipse and 1.5 cm everted nipple. Ink code: Anterior/superior-blue, anterior/inferior-orange, posterior-black. The specimen is serially sectioned into 12 slices from lateral to medial with nipple in slice 8 revealing a 2.7 x 2.5 x 2.5 cm white-tan firm infiltrating mass in the mid upper breast in slices 7-9 that.  is closest to the anterior margin at 0.5 cm. There is a clip located within the mass. Adjacent to the mass is a biopsy site with biopsy clip and surrounding granular tissue spanning ~ 4 cm in slices 4-7 in the upper outer quadrant. Tissue is procured. Representatively submitted: E1: slice 7, mid anterior including bisected mass E2: slice 7, mid posterior including bisected mass (clip) E3: slice 7, fibrous tissue inferior to mass E4: slice 8, margin deep to mass E5: slice 8, mass E6: slice 9, mass, UIQ E7: slice 6, mid-superior E8: slice 6, mid anterior (with clip) E9: slice 5, mid superior E10: slice 5, deep margin E11: slice 4, upper anterior margin E12: slice 4, lower anterior margin E13: slice 3, superior mid E14: slice 2, midsection E15: slice 4, lower outer quadrant E16: slice 5, lower outer quadrant E17: slices 7-8, lower inner quadrant E18: slices 9-10, lower inner quadrant E19: nipple E20: nipple and skin
+
+--- Page 2 ---
+F. ADDITIONAL AXILLARY TAIL RIGHT BREASTE  Received in formalin labeled with the patient's identification and "additional axillary tail right breast" are multiple tan pink soft tissue fragments aggregating to 3 x 2 x 1cm. No lymph node is grossly identified. Toto F1-F3. G. SCALP LESION Received in formalin labeled with the patient's identification and "scalp lesion" is a tan white firm well circumscribed mass 1.4 x 1.3 x 1cm. The resection margin is inked black and the specimen is trisected. Toto G1. DIAGNOSIS: A. SENTINEL LYMPH NODE #1, RIGHT AXILLA, BIOPSY: - ONE LYMPH NODE, NO TUMOR SEEN (O/1) B. SENTINEL LYMPH NODE #2, RIGHT AXILLA, BIOPSY: - ONE LYMPH NODE, NO TUMOR SEEN (O/1). SENTINEL LYMPH NODE #3, RIGHT AXILLA, BIOPSY: - ONE LYMPH NODE, NO TUMOR SEEN (O/1). D.  SENTINEL LYMPH NODE #4, RIGHT AXILLA, BIOPSY: - TWO LYMPH NODES, NO TUMOR SEEN (0/2). E. BREAST, RIGHT, MASTECTOMY: - INVASIVE DUCTAL CARCINOMA, SBR GRADE 3, WITH FOCAL SQUAMOUSE FEATURES AND NECROSIS. - TUMOR MEASURES 2.7 CM. - MARGINS, NO TUMOR SEEN. - DUCTAL CARCINOMA IN SITU (DCIS), SOLID TYPE, NUCLEAR GRADE 3,E WITH NECROSIS AND MICROCALCIFICATIONS, INVOLVING LOBULES. - SKIN AND NIPPLE, NO TUMOR SEEN. F. ADDITIONAL AXILLARY TAIL, RIGHT, EXCISION: - FIBROADIPOSE TISSUE, NO TUMOR OR LYMPH NODES SEEN. G.  SCALP, LESION, EXCISION: - PILAR CYST. SYNOPTIC REPORT - BREAST Specimen Type:  Mastectomy Needle Localization: No Laterality: Right Invasive Tumor: Present Multifocality: No WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Tumor size: 2.7cm Tumor Site: 12:00 Margins: Negative Distance from closest margin: 0.5cm anterior Tubular Score: 3 Nuclear Grade: 3 Mitotic Score: 3 Modified Scarff Bloom Richardson Grade:. 3 Necrosis: Present Vascular/Lymphatic Invasion: None identified Lobular neoplasia:  None Lymph nodes: Sentinel lymph node only. Lymph node status: Negative 0/5 DCIS present  Margins uninvolved by DCIS DCIS Quantity:Estimate 15% DCIS Type: Solid Cribriform DCIS Location:Both associated and separate from invasive tumor mass Nuclear grade: High Necrosis: Present Location of CA++: DCIS
+
+--- Page 3 ---
+ER/PR/HER2 Results ER: Positive PR: Positive HER2: Positive by FISH Pathological staging (pTN): pT 2 N O CLINICAL HISTORY: None provided  PRE-OPERATIVE DIAGNOSIS: Right axilla INTRAOPERATIVE CONSULTATION: TPA-TPB-TPC-TPD: Negative for tumor on touch prep. Diagnosis called by Dr. to Dr. ai (A-C) and (D). Gross Dictation: Pathologist, I  Microscopic/Diagnostic Dictation: Pathologist, : Final Review: Pathologist, Final: Pathologist,.
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diff --git a/output/text/f3de49fc-616f-48bf-81a3-f6074e86f0a9.txt b/output/text/f3de49fc-616f-48bf-81a3-f6074e86f0a9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a59674bae02fedb5a08f6ead3e9c6bef0998a6d5
--- /dev/null
+++ b/output/text/f3de49fc-616f-48bf-81a3-f6074e86f0a9.txt
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+
+--- Page 1 ---
+UUID: 27D59446-D8BA- 4DB0-8F47-3C06630A264F Redacted TSs Patient ID: Surgical Date: Gross Description: Renal tumor is located in a pole, moderately-margin, soft, solid, or necrotic or yellow, gray surface with 8x6x5cm in size, infiltrating capsules Microscopic Description: Tumor is is composed of elongated papillary, back to back, variability in shape and size, lined by moderrately straitified cylindrical or cuboidal cells with fine vascula-fibrous core. Nuclei are irregular large, hyperchromatic with prominent nucleioli. Mitoses are present. Cytoplasm are moderate, eosinophilic or clear. ID c 3 Diagnosis Details: Renal cell carcinoma, papillary type Carenomo,papllery neral Comments: ceQQ 8Qto/3 Formatted Path Reports: KIDNEY TISSUE CHECKLiST Qt J~51ko/14 Specimen type: Radical nephrectomy Tumor site: Kidney Tumor size: 8 x 6 x 5 cm. Focality: Not specified Histologic type: Papillary renal cell carcinoma Histologic grade: Moderately differentiated Tumor extent: Other - Lung. Lymph nodes: 3/3 positive for metastasis (Hilar 3/3) Lymphatic invasion: Not specified Venous invasion: Not specified Margins: Not specified Evidence of neo-adjuvant treatment: No Additional pathologic findings: Not specified Comments: Right 1H+312013
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diff --git a/output/text/f416be2d-3f9b-4dfe-b188-ed0e4f1284d2.txt b/output/text/f416be2d-3f9b-4dfe-b188-ed0e4f1284d2.txt
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index 0000000000000000000000000000000000000000..70f70fa8296799bf3b84dce6d4551678ebee9f9d
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+Sex. D.O.8.: MRN # Ref Phy.... SPECIMEN INI Collected: Received: Reported: SURGICAL PATHOLOGY REPORT DIAGNOSIS... DIAGNOSIS: A. Ureter, right, surgical margin, biopsy with frozen section evaluation: Negative for malignancy. Frozen section diagnosis A contirmed.. riten agnosis Discre B. Ureter, left, surgical margin, biopsy with frozen section evaluation: Negative for malignancy. ual/Syr Frozen section diagnosis B confirmed. ase is (circle) DISQUAL C. Urinary bladder, radical cystoprostatectomy: Tumor Characteristics: 1. Histologic type: Urothelial (transitional cell) carcinoma with focal squamous differentiation. 2. Histologic grade: Grade II (poorly differentiated). 3. Tumor size:5.0 by 2.0 cm. 4. Microscopic tumor extension: Malignancy extends completely through the muscular wall of the bladder and into paravesicle adipose tissue. 5. Lymphovascular space invasion: Present. Surgical Margins: 1. Margins uninvolved: Right and left ureters (see parts 1 and 2): paravesicla soft tissues. 2. Margins involved: None identified. Other: 1. Associated epithelial lesions: Mutifocal high-grade urothelial dysplasia/flat carcinoma in situ is present.. 2. Other significant findings: Lymph nodes, left peivic, excision (see part 4): Metastatic high-grade urothelial carcinoma, one of two nodes.. 3. pTNM stage: pT3a, N1. Prostate gland, radical cystoprostatectomy: Tumor Characteristics: . Histologic type: Adenocarcinoma. 2. Prostate size: 4.5 x 4.0 x 3.0 cm. Tumor quantitation: Malignancy is present in both right and left lobes, and estimated to account for approximately 10% of the prostate voiume.. 3 4. Gleason grade:. a. Primary patten: 3/5. b. Secondary pattern: 3/5. 1cD-O3 c. Total Gleason score: 6/10. CaFCi numa,wo+hesiq1, NO5 5 Extraprostatic extension: Not identified.. 6. Seminal vesicle invovement: Not applicable; seminal vesicles not identified grossly. 81 ao/3 7. Lymphovascular space invasion: Not identified. 8. 1 Perinaural invasion: Not Identified. Sik: 9. High grade PIN: Not identified. cQcF- bladder,N0s c67.9 10. Treatnent effect. Not identified. Surgical Margin Status: 1. Margins uninvoived: Right and lot lobes laterally, prostate base. pAyh -bladcer, cnknor wa11 2. Margins involved: Prostatic apex, single microscopic focus. Lymph Node Status: cu73 1. Total number of lymph nodes received: 2 (see part 4). 6--12 Total number of lymph nodes containing metastatic prostate carcinoma: 0. Other: pTNM stage: pT2c, NO D. Lymph nodes, left peivic, excision: UUID:702DCFCC-C28D-4122-B12F-DED2154826BE Metastatic high-grade urothelial carcinorna, one of two nodes.. TCGA-GC-A3YS-01A-PR Redacted Negative for metastatic prostatic adenocarcinoma.
+
+--- Page 2 ---
+Electronic Signature:d COMMENTS: The malignancy in the bladder corresponds to those in prior bladder biopsies, The single invoived tymph node damonstrates a high-grade epithellal malignancy, histologically identical to that in the bladder. The malignancy does not resemble the prostatic adenocarcinoma. This case has been reviewed in intradepartmental consuitation and as part of the  agreement with the diagnosis. CLInICAl HIStOry: Preoperative Diagnosis: Not given Postoperative Diagnosis: Symptoms/Radiologic Findings: SPECIMENS: A. Right ureter clip on distal end B. Left ureter clip on distal end C. Bladder and prostate D. Left pelvic lymph node GROSS DESCRIPTION: A. The first container A is labeled with the patient's name 'right ureter dlip on the distal end.' The specimen consists of a segment of ureter  measuring 0.2 cm in length, 0.5 cm in diameter. The specrnen was exanined at the time of surgery and the frozen section is subsequently entirely. submitted in a single cassette 8. The second container B is labeled with the patient's name 3nt ureter.: The specimen consists ot a segment of ureter rmeasuring 0.2 cm.  in length and 0.5 cm in diameter. The specimen was examined at the time of surgery and the frozen section is subsequently entirely submitted in a single cassette labelec. C. The third container C is labeled with the patient's name  bladder and prostate. The specimen consists ot a bladder with attached  prostate and attached perivesicular fat measuring in total 13.0 x 12.0 x 7.5 cm and weighs 312 grams. The bladder itself measures 7.5 x 7.0 x 6.0 cm.. The soft tisue resection margin is yellow to brown-tan, shaggy. The margin has been inked black. The prostatic urethral margin has been inked blue. The bladder is opened anterloriy. The mucosa is gray-tan to brown-tan displaying a gray-brown shaggy mass prinarily on the anterior wall that.  measures 5.0 x 2.7 cm that extends down to the trigone area, is within 2.5 cm of the prostatic urethral margin. The right and len ureters are probed and patent and are uninvoived by the mass. On sectioning through the mass, the rnass extends into the undertying wall. The cut surface is gray-tan and fibrotic. Depth of invasion approximateiy 1.8 cm and comes within 0.3 cm of the inked deep margin. The prostate measures 4.5 x 4.0 x 3.0 cm. The Surface is yollow to gray-tan fibrous. There are no lesions identified groseh Tha camiral vesicles, vas deferens are not identified. Received with the. anacimen are three cassettes, one green, one yellow, one blue labeled.  Representative sections are submitted in cassettes labeled s follows: Perpendicular sections taken from the prostatic uremras margin in blocks 1 and 2; full thickness soctions taken from tha  mass in orxrs 3 tnrough 7; random sections from uninvolved bladder mucosa from the floor, block 8; trigone area block 9; left distal ureter margin, block 10; proximat left ureter taken at the urethra orifice block 11; right distal ureter margin, block 12; right proximal ureter taken at the orifice in block 13; left. prostate lobe, block 14; right prostate lobe, block 15: perpendicular sections taken from the base of the prostate, block 16. D. The fourth container D is labeled with the patient's name. 'left pelvic lymph node.' The specimen consists of a portion of fibroadipose. tissue measuring 4.5 x 3.5 x 1.0 cn. Sectioning reveals two probable lymph nodes that measura 1.8 and 2.5 cm. The lymph nodes are entirely submitted in naesettes labeled n as follows: One probable node trisected, blocks 1 and 2; one probable node trisected in blocks 3 through 5. INTRA-OPERATIVE CONSULTATION: FROZEN SECTION DiAGNOSES: Parts A and B: Negative per Dr.
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+mfi1TnsF,rj ductl, nos 8.500/3 Procedure Date. Carciuma S.ts Breast, 'nus C5 0.9 Procedure Physician:e Criterla Yt Attending Physician/Copies To: 21/11 DiagnosDiscr lu Deni/S DISQUAU UUID:982253AB-2C41-4E7A-9178-8690FF09FF78 PatIent hIstory: TCGA-BH-A1ES-01A-PR 'Redacted 1 & 2 TAKEN BY PATH DATE OF LMP DATE OF LAST DELIVERY: PRE-OP DIAGNOSIS: R BREAST CANCER POST-OP DIAGNOSIS: SAME OPERATIVE PROCEOURE: R MASTECTOMY, SENTINEL NODE BX'S CLINICAL HISTORY: I & 2 TAKEN BY PATH MATERIAL SUEMITTED: A) RIGHT SENTINEL LYMPH NODE, PROCUREMENT BY SURGICAL PROCEDURE #1 B) RIGHT SENTINEL LYMPH NODE, PROCUREMENT BY SURGICAL PROCEDURE 2 C) RIGHT AXILLARY LYMPH NODE(S), PROCUREMENT BY SURGICAL PROCEDURE D) RIGHT BREAST BIOPSY/MASS/SEGMENTAL MASTECTOMY, PROCUREMENT BY SURGICAL PROCEDURE E) RIGHT SENTINEL LYMPH NODE, PROCUREMENT BY SURGICAL PROCEDURE #3 F) RIGHT SENTINEL LYMPH NODE, PROCUREMENT BY SURGICAL PROCEDURE H4 INTRAOPERATIVE CONSULTATION: FROzeN secrIon: 1) Sentinel node #1: 0.6 cm lymph node. Frozen Section diagnosis: Negative for tumor by Touch Prep and Frozen Section. 2) sentinel node #2: 0.8 cm iymph node. Frozen Section diagnosis: Negative for tumor by Touch Prep and Frozen Section. 3) Sentinel node #3: 0.8 cm iymph node. Frozen Section diagnosis: Negative fro tumor by Touch Prep. 4) Sentinel node #4: 0.6 cm iympn node. Frozen Section diagnosis: Negative for tumor by Touch Prep. consult: Mastectomy: 21.0 by 12.0 by 3.0 cm breast tissue with 13.0 by 5.5 cm skin ellipse, and blue dye at 12:00 position. Inked and sectioned revealing a 2.0 by 2.0 by 2.3 cm iight-tan, well position under nipple.. A second, 0.5 cm nodule is found inferior to'(and 2.0'cm from) first nodule. Margins free of tumor. FINAL DIAGNOSIS: AFS) RIGHT SENTINEL LYMPH NODE #1: - ONE (1) LYMPH NODE FOCALLY POSITIVE FOR METASTATIC CARCINOMA (SEE NOTE) BFS) SENTINEL LYMPH NODE #2: - ONE (1) LYMPH NODE NEGATIVE FOR TUMOR C) RIGHT AXILLARY LYMPH NODE: - ONE (1) LYMPH NODE NEGATIVE FOR TUMOR D) RIGHT BREAST: EXTENSIVE DUCTAL. FABCTNOMA IN-SITU, IMMEDIATE NUCLEAR GRADE WITH CENTRAL NECROSIS REPRESENTING 6O% OF TUMOR VOLUME: - FAT NECROSIS, HEMORRHAGE AND GRANULATION TISSUE CONSISTENT WITH BIOPSY SITE AND RESIDUAL DUCTAL CARCINOMA IN-SITU INTRAOUCTAL PAPILLOMA INTRAMAMMARY LYMPH NODE, NEGATIVE FOR TUMOR - SKIN AND NIPPLE, NOT REMARKABLE - MARGINS FREE OF TOMOR E) RIGHT SENTINEL LYMPH NODE #3: - NEGATIVE FOR TUMOR F) RIGHT SENTINEL LYMPH NODE #4: -' NEGATIVE FOR TUMOR NOTe: The metastatic focus is present in a vascular space in the capsule. AEl/AE3 and EMA are positive. AE1/AE3 and EMA on the other sentinel lymph nodes are negative. ER/PR ahd HER- 2/neu will be performed on block *di". SUPPLEMENTREPORT (ER/PR) My signature below is attestation that t have reviewed all slides and agree with the findings as noted below. IMMUNOPEROXIDASE IDENTIFICATION OF ESTROGEN AND PROGESTERONE RECEPTORS IS CARRIED OUT ON SLIDE "D1".S DISTINCT INTRANUCLEAR STAINING IS IDENTIFIED FOR ESTROGEN RECEPTOR (3OS) AND PROGESTERONE RECEPTOR (<IO%). THEREFORE, ESTROGEN RECEPTOR IS INTERPRETED AS BORDERLINE AND PROGESTERONE RECEPTOR AS. NEGATIVE.S PATHOLOGIS SUPPLEMENTREPORT (HER2/nEU) My signature below is attestation that I have reviewed all slides and agree with the findings as noted below. AS PER THE REQUEST QF DR.  c-erbB2 IHER-2/NEU) IMMUNOSTAINING IS CARRIED OUT ON PREVIOUS MAGEE SURGICAL  GSOCK "DI" (BREAST CANCER) USING A 1:30O DILUTION OF DAKO'S POLYCLONAL ANTIBODY A485 (DIRECTED AGAINST THE INTRACELLULAR DOMAIN OF C-erbB2) WITHOUT ANTIGEN RETRIEVAL. NO DISTINCT COMPLETE MEMBRANE STAINING IS IDENTIFIED. THEREFORE, C-erbB2 (HER-2/NEU) IS INTERPRETED AS NEGATIVE (SCORE O).
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+zcD-o-3 UUID:6104CA0C-86CD-46C9-A111-0024A75FB727 Redacted Carcinsno-Adrenalesrtica) 8370/3 SiTe O Adrenol Gavd,esrteL C 74 d Procedure: L adrenalectomy Yts q|6/13 Gross description: 12.5 x 10.5 x 7cm, 467g Diagnosis: adrenocortical carcinoma, Kl67 5-10%; , pT2 pNx L1 V1 Pn0 R0 Reference Pathology only: none Weiss score: 7 Hough score: 3.52 Van Slooten score: 22.7
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diff --git a/output/text/f49a2fda-cca7-493f-b912-991cd1f72950.txt b/output/text/f49a2fda-cca7-493f-b912-991cd1f72950.txt
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+Page 1 of 3 UUID: BFAB9079-A4A6-457C-8CF5-3D8BB15FEB4D TCGA-5X-A7SQ-01A-PR Redacted IcDs-3 826D/3 Surgical Pathology Report. O 101413 *Final* Surgical Pathology Report. Clinic Number:. Name: Requested By: DIAGNOSIS: Kidney, left, nephrectomy: Two tumors identified. Tumor #1 Histologic type: Papillary renal cell carcinoma (see comment). Histologic Fuhrman grade: Grade 2/4. Tumor size: 3.5 x 3.0 x 2.5 cm. Tumor site: Lower pole. Tumor focality: Not applicable.. Sarcomatoid features: Absent.. Tumor necrosis: Absent.. Microscopic tumor extension: The tumor extends into the renal sinus. Margins: Not involved. Lymphovascular invasion: Absent. Lymph nodes: No lymph nodes found in hilar fat. DIAGNOSIS COMMENT: Immunostains in tumor #l showed:.
+
+--- Page 2 ---
+Page 2 of 3 racemase: positive CK7: positive C-Kit: negative. cD10:only rare positivity. The results are those typically reported in papillary renal cell carcinoma. CLINICAL INFORMATION: Left renal mass. SPECIMEN(S) : A:Left kidney PRELIMINARY INTRAOPERATIVE DIAGNOSIS:S Intraoperative Pathologist(s) : A. Left kidney, frozen section diagnosis: Renal cell carcinoma. Tissue sent for GROSS DESCRIPTION: Performed by A. Received fresh labele and "left kidney." Procedure: Radical nephrectomy. Specimen laterality: Left. Tumor site: Lower pole and a second tumor upper pole inferior. Tumor size: Lower pole tumor: 3.5 x 3 x 2.5 cm. Upper pole tumor: 1.8 x 1.5 x 1.5 cm. Tumor focality: Multifocal. Gross extent of tumor:. Extension into perinephric tissue: Present. The tumor in the lower pole abuts the renal sinus and perinephric tissue.. Extension beyond Gerota's fascia: Absent. Extension into renal sinus: Absent.. Extension into collecting system: Absent.. Adrenal gland: Adrenal gland absent.. Gross notes: Gross tumor characteristics: The tumor #1 in the lower pole is necrotic and somewhat papular. Tumor #2 in the upper pole is well-circumscribed and yellow-orange with focal necrosis. Kidney weight: 478 g with fat and 184 g without fat.. Kidney dimensions: 10.5 x 6 x 5.2 cm. Ureter dimensions: 6 x 0.4 x 0.3 cm. Lymph nodes: Absent. Inking details: The perinephric fat is inked over the mass in. the lower pole. Block summary for specimen A,. Al) Frozen section - tumor; A2) ureteral and vascular margins; A3-A4) sections of tumor #1 in lower pole; A5) fat in capsule over lower pole tumor; A6-A7) sections of upper pole tumor; A8) section of lower pole tumor abutting renal sinus.
+
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+Page 3 of 3 Support for the diagnosis in this case may have included the use of immunohistochemistry tests that were developed and whose performance characteristics were determined by They have not been cleared. or approved by the U.s. Food and Drug Administration (FdA). The FDA has determined that such clearance or approval is not necessary. These tests should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 ('cLIA') as qualified to perform high complexity clinical laboratory testing. 99/13
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+/cs-0 -3 c50.9 Sifn: suast, Nos 7 Final Diagnosis Breast, right, wide local excision: Infiltrating lobular carcinoma, Nottingham grade II (of 1II)[tubules 3/3, nuclei 2/3, mitoses 1/3; Nottingham score 6/9], forming a 5.2 x 3.0 x 2.6 cm mass. Lobular carcinoma in situ is present and represents less than 5% of the overall tumor volume. Angiolymphatic invasion is present. The non-neoplastic breast parenchyma show. nonproliferative fibrocystic changes. Calcifications present in benign ducts and acini. Biopsy site changes present. The inferior and medial margins are positive for invasive carcinoma. Breast, right, total mastectomy: Infiltrating lobular carcinoma, Nottingham grade II (of III), involving the medial aspect of the biopsy cavity. Two additional nodules of Nottingham grade II. (of IIl) invasive lobular carcinoma are identified in the lower outer quadrant (0.7 x 0.6 x 0.5 cm, located 1.4 cm from the deep margin; and 0.5 x 0.4 x 0.4 cm, located 1.2 cm from the deep margin). Lobular carcinoma in situ is present and represents less than 5% of the overall tumor volume. Angiolymphatic invasion is present. The non-neoplastic breast parenchyma shows proliferative fibrocystic changes. Biopsy site changes present. The tumor does not involve the nipple, overlying skin, or underlying chest wall. All surgical resection margins, including the deep margin, are negative for tumor (residual tumor in the biopsy cavity is located 2.2 cm from the deep margin). Lymph nodes, right axillary, dissection: Multiple (5 of 18) right axillary lymph nodes are positive for metastatic carcinoma [AJCC pN2]. The largest is represented by a matted mass of lymph nodes and measures 4.2 x 2.6 x 2.4 cm. Extranodal extension is present. Comment: Final (mastectomy) surgical margins are widely free of involvement.. UUID: 73FFBADB-37C0-4F17-8C95-F8DC94EF1AD3 TCGA-AR-A2LK-01A-PR Redacted
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diff --git a/output/text/f4c6690e-4ff8-4ac3-95d6-f8c2647a2581.txt b/output/text/f4c6690e-4ff8-4ac3-95d6-f8c2647a2581.txt
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+--- Page 1 ---
+Case ID Gross Description
+
+--- Page 2 ---
+Microscopic Description Diagnosis Details
+
+--- Page 3 ---
+Comments Formatted Path Report LARYNX TISSUE CHECKLIST Specimen type: Laryngectomy Tumor site: Glottis Tumor size: 4 x 4 x 2 cm Histologic type: Squamous cell carcinoma Histologic grade: Well differentiated Tumor extent: Vocal cord Lymph nodes: 0/14 positive for metastasis (Regional 0/14) Margins: Not specified Evidence of neo-adjuvant treatment: Not specified Comments: None
+
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+Laterality ID
+
+--- Page 5 ---
+Excision date Case ID
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diff --git a/output/text/f512ca94-7268-43d4-8bc8-6d71acdc782d.txt b/output/text/f512ca94-7268-43d4-8bc8-6d71acdc782d.txt
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index 0000000000000000000000000000000000000000..42f9062f9acbc34e61faafdf409e8fd44e23c169
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+Pathology Report ***** MODIFIED REPORT - REVIEW ADDENDUM SECTION *** ADDENDUM COMMENT Immunoperoxidase study for keratin 7demonstrates that the tumor cells are positive. The results of the study are consistent with the diagnosis of chromophobe renal cell carcinoma. The supplemental report is being issued to report the results of an additional study performed after the original diagnosis was issued. There is no change in the diagnosis.. DIAGNOSIS (A) RIGHT KIDNEY: CHROMOPHOBE RENAL CELL CARCINOMA, FUHRMAN NUCLEAR GRADE 3 (3.0 CM). (SEE COMMENT) TUMOR CONFINED TO THE KIDNEY Ureteral, vascular and soft tissue margins of resection free of. tumor. COMMENT Immunoperoxidase studies demonstrate that the tumor is positive for keratin and EMA and negative for CD10 . The results of the. immunoperoxidase studies support the diagnosis of chromophobe renal cell carcinoma. The stain for keratin 7 is pending. A supplemental report will follow. GROSS DESCRIPTION (A) RIGHT KIDNEY - The specimen consists of a right kidney with perinephric adipose tissue (overall 12.0 x 6.0 x 5.0 cm), consisting of kidney (10.0 x 5.0 x 3.5 cm), and to the attached unremarkable ureter (2.0 cm in length and 0.3 cm in diameter).. A well-circumscribed tumor (3.0 x 3.0 x 2.5 cm) has a tan-brown homogeneous appearance without necrosis or hemorrhage. The tumor is in the middle of the kidney, closely abuts the perihilar adipose tissue. No gross invasion into the sinus adipose tissue is identified. The tumor is well confined in the renal parenchyma (0.7 cm away from the closest renal capsule). No hydronephrosis is identified. The remaining renal parenchyma is grossly unremarkable.. INK CODE: The perinephric adipose tissue surface close to the tumor is inked black. SECTION CODE: A1, ureter and renal wing margin, en face; A2-A5, tumor with adjacent pelvis and perihilar adipose tissue; A6-A8, tumor with adjacent renal parenchyma and perinephric adipose tissue; A9, tumor with adjacent renal parenchyma; A10, tumor alone; A11, renal parenchyma next to the tumor; A12, unremarkable renal parenchyma away from the tumor. Representative sections of the tumor are submitted to the tumor bank and the remainder of the tumor is entirely submitted for permanent section. 1
+
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+CLINICAL HISTORY Right renal mass.. CONSULTANT(S) SNOMED CODES
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+Patient Name: Accession #: Med. Rec, #: Date of Procedure. DOB: Date of Receip! Gender: Date of Report Ref. Physician. Account #: Patient Address Billing Type Additional Copy to: Ret Source. sis & History: ith parlial nephreclomy, now with ipsilateral recurrence. Specimens Submitted: 1: SP: Lymph nodes, paracaval; excisic 2: SP: Kidney, right; total nephrectomy 3: SP: Sof tissue, perinephtric; excisior 4: SP: Lymph nodes #2, paracaval: exq DIAGNOSIS: SP: Lymph nodes, paracaval; excisior Lymph Nodes. Not identified Benign lbroadipose tissue; no lymph nodes identified in entirely submilled specimen SP: Kidney, right; total nephrectomy Tumor Type: Renal cell carcinoma - Papillary type Type 2 Fuhrman Nuclear Grade: Nuclear grade II/IV Tumor Size: Greatest diameter is 3.8 cm. Local Invasion (for renal cortical types): Invoives renal hilar fat Renal Ven Invasion: Not identified Surgical Margins: Free of tumor Non-Neoplastic Kidney: Unremarkabte Adrenal Gland. Not identified Lymph Nodes: Not identified  Staging for renal cell carcinoma/oncocylona: Page 1 01 3
+
+--- Page 2 ---
+pT3a Tumor invades the adrenal gland or perinephric lissues but not beyond Gerota's fascia. 3.  SP: Soft tissue, perinephric; excisior Fibroadipose tissue with fibrosis, fat nec I camicalion; no tumor seen. SP: Lymph nodes #2, paracaval; excision Lymph Nodes: Not invoived Number of nodes examined:7 Benign sogment of ureter.. TATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (ANDIOR OTHER MATERIAL), AND THAT IHAVE REVIEWED AND APPROVED THIS REPORT Gross Description: 1)The specimen is received fresh, labeled "paracaval lymph node" and consists of a 2.4 X 1.8x 0.4 cm fragment of tan red lissue. No definite lymph nodes are identified. Entirely submitted. Summary of seclions:. U -- undesignated perinephric fal weighing 281.5 g in total. The kidney measures 7.9 x 5.2 x 5.0 cm. The atlached ureter measures 2.4 cm in length and O.4 cm in diameter. The allached renal vein measures 1.9 cm in length and 0.3 cm in diameter. The renal vessels and ureter margins are grossly unremarkable. An adrenal gland is not identified. There is a 2.9 x 2.3 cm previous excision site al a. kidney pole. The excision site is inked blue while the remainder of the kidney is inked black. The kidney is bivalved to reveal a. 3.8 x 3.7 x 3. I cm largely hemorrhagic and partially gold - lan tumor that is located in the hilar fat. Seclions through the remainder. of the kidney reveal pink- brown parenchyma, with a well-defined cortico-medullary junction. The cortex measures 0.6. d the calyces appear normal. No lymph nodes are identified in the perinephric fat. Representative sections are submitted fo!. and for permanent sections. Photographs are taken. Summary of seclions:. UVM -- ureteral and vessel margins T.fumor THF-- tumor with hilar fal. TSF -- tumor wilh sinus fat TK -- tumor with adjacent kidney TC -- lumor to capsule K -- represenlative sections kidney  BX -- previous excision site 3) The specimen is received fresh for frozen section consullation, labeled "perinephric soft tissue stitch marks area of interest' and consists of a iragment of fibroadipose measuring 5.0 x 3.7 x 2.4 cin. The specimen is focally suraced by a 3.5 x 1.0 cm fragmen! of fibromembranous tissue. The area around the stitch is inked black. Tho remainder of the specimen is inked blue. Cut surfaces show a 2.9 x 2.3 x 1.5 cm area of fat necrosis with a capsule. There are multiple surgical staptes within the. specimen. Representatively submilted for frozon section. Page 2 of 3
+
+--- Page 3 ---
+! SURGICAL PATHOLOGY REPORT Summary of sections:. FSC -. (rozen section contro) U -- additional representative sections 1 4)The specimen is received in formalin labeled "paracaval lymph nodes #2" and consists of a 3.2 x 2.0 x 0.3 cm irregular tibrofally soft tissue fragment to include mulliple,pink tan falty lymph nodes ranging from 0.4 cm up to 2.8 cm in greatest  dimension. All identified lymph nodes and the remaining fibrous tissue is entirely submilted. Summary of sections:. BI.N-bisected lymph nodes LN-lymph nodes U - undesignated Summary of Sections:. Part 1:  SP: Lymph nodes, paracaval; excisic Block Sect. Site PCs 1 U 2 Part 2:  SP: Kidney, right; total nephrectomy Block Sect. Site PCs 1 BX 1 1 K 1 1 T 2 1 tc 1 THF 3 1 TK NN 1 TSF 1 uvm 3 Part 3:$P: Soft tissue, perinephric; oxcislo! Block Soct. Sito PCs 1 FSC 4 U 4 Part 4: SP: Lymph nodos #2, paracaval; excisio Block Soct. Sito PCs 2 bin 2 2 In 2 1 u 1 Intraoperative Consattation: Note:  The diagnoses given in this seclion perain only to tho tissue sample examined at the time of the intraoperative consultation. 3) FROZEN SECTION DIAGNOSIS: PERINEPHRIC  SOFT TISSUE (FS): FIBROSIS AND CALCIFICATION (LIN) PERMANENT DIAGNOSIS: SAME Page 3 of 3 END OF REPORT
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+1es-0-3 C 50.9 Site: buast, NoS FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORTS Patient: Specimen #: FMP/SSN: DOB/Age/Sex: Race: WHITE Taken: Location: Received: Physician(s) :. Reported: SPECIMEN: A: LEFT BREAST LUMPECTOMY B: LEFT AXILLARY CONTENTS C: SENTINEL NODE #1 FINAL DIAGNOSIS: A. BREAST, LEFT, LUMPECTOMY: TUMOR TYPE: INFILTRATING DUCTAL CARCINOMA NOTTINGHAM GRADE: POORLY DIFFERENTIATED (Grade 3) NOTTINGHAM SCORE: 9 0F 9 (Tubules= 3, Nuclei= 3, Mitoses= 3; mitotic count 24 per 10 high power fields at 40x power) TUMOR SIZE: MULTIFOCAL, LARGEST CONTIGUOUS FOCUS 1.3 CM (GrOSS) measurement) MICROCALCIFICATIONS: NONE IDENTIFIED VENOUS/LYMPHATIC INVASION: PRESENT  MARGINS : INFILTRATING CARCINOMA 0.8 MM FROM ANTERIOR MARGIN (Slide A1O) FOCI OF ANGIOLYMPHATIC INVASION O.2 MM FROM POSTERIOR MARGIN (slide A2) INTRADUCTAL COMPONENT: DCIS, FOCAL, HIGH GRADE LYMPH NODES: NEGATIVE (See parts B and C) NIPPLE: NOT SAMPLED SKIN: NOT SAMPLED  HORMONE RECEPTOR AND HER2 STUDIES: PREVIOUSLY REPORTED  PATHOLOGIC STAGE: pT1 NO MX (AJcC Stage I) B. AXILLARY CONTENTS, REMOVAL: BENIGN FIBROADIPOSE TISSUE C. SENTINEL LYMPH NODE, REMOVAL: - NEGATIVE FOR TUMOR BY H&E AND IMMUNOHISTOCHEMISTRY Report Electronically Signed Out * UUID:63F76DB5-8433-4EFE-9054-6C04F065DF2D TCGA-A2-A0SX-01A-PR Redacted e1 Continued on Next Page IAL DATA - PRIVACY ACT OF 1974
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+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: CLINICAL DIAGNOSIS AND HISTORY: year old with diagnosis of left breast cancer. PRE-OPERATIVE DIAGNOSIS: left breast cancer. GROSS DESCRIPTION: A. Received fresh is an 8 x 7 x 2.5 cm unoriented irregular piece of soft. tissue with embedded localization wire. The radiograph accompanies the specimen. The external surface is composed of focally disrupted lobulated. yellow tan adipose tissue. A 3 x 1 cm irregular portion of red brown muscle is denoted on one surface which is smooth and consistent with a deep fascia margin. This surface is inked black and the remainder of the specimen is inked blue. Serial sections reveal a 1.3 x 1.2 x 1.2 cm soft. ink tan Mammomark plug with embedded clip. This lesion comes to within 0.2 cm of both inked margins. The remainder of the specimen is composed of unremarkable adipose tissue admixed with scant fibrous tissue. No. additional lesions are identified. Representative sections submitted as. follows: Al: lesion A2-A3: margins of A1 A4: adjacent normal. A5: margin (blue ink). A6-A15: representative sections Matched sections of Al and A4 are submitted in Tor cbcp protocol. R Rereived in formalin labeled with the patient's name. desiqnated "AXILLARy CONTENTs LEFT" consists of a single fragment of pink tan tissue measuring 2.5 x 1.9 x 0.9 cm which is grossly. unremarkable. The entire specimen is submitted whole. There are no lymph. nodes identified. C. Received fresh labeled with the patient's name designated "sINGLE NODE #1" is a 1 x 0.7 x 0.3 cm lymph node. The specimen is bisected to reveal a fatty hilum with a hemorrhagic rim of lymphoid tissue. The specimen is entirelv submitted in Cl. No tissue is taken for protocol. Page 2 End of Report. FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
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diff --git a/output/text/f569ce76-cfa9-4bfd-9289-2369de7c5cd4.txt b/output/text/f569ce76-cfa9-4bfd-9289-2369de7c5cd4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7c2e6b651d9a36ce796c3e24853a94084e46a3d5
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+Surgical Pathology Report Case #: Name: DOB: Collected: Gender: Received: MRN: Reported: Copy To: Location: Physician: Pathologic Interpretation: A. LEFt`BrEASt  Lump mASS (1 STTiCh SUpeRiOR, 2 StITCheS LATerAL, 3 StItCheS DEeP): - iNVASIVE DUCTAL CARCINOMA, MICROPAPILLARY TYPE, MODERATELY DIFFERENT!ATED, Nottingham grade 2 (3+2+1=6), 1.9 cm in greatest microscopic dimension. - Lymphovascular invasion is seen. - Resection margins are free of invasive carcinoma, closest margin is the anteror (4 mm). - IN SITU DUCTAL CARCINOMA, INTERMEDIATE NUCLEAR GRADE (DIN 2) WITH EXTENSIVE NECRQSIS cribriform type, representing 10% of tissue sampied. - Resection margins are free of DCiS, closest margin is the anterior (10 cm) - Previous biopsy site - See tumor summary. - AJCC: pT1c, pN1a, pMn/a B. LEFT AXILLARy CONTeNTS: - Metastatic carcinoma in one out of twenty-three lymph nodes (1/23). - Largest metastatic deposit is 2.5 mm. Tumor Summaryd Jcs-0-3 Specimen: Cavni ona, rivasiv muropapilley 8507/3 - Partial breast Procedure: Site: 6rest N0s C5u.9 3fp/n - Excision without wlre-guided localization Lymph Node Sampling:e M - Axiliary dlssection (partial or complete dissection) Specimen Integrity: - Single intact specimen (margins can be evaluated) Specimen Size: - Greatest dimension: 11.5 cm * Additional dimension: 7.5 x 3.5 cm. Latorality: - Left ) Tumor Size: Size of Largest Invasive Carcinoma - Greatest dimenslon of largest focus of invasion over 0.1 cm: 2 cm Tumor Focallty: - Single focus of invasive carcinoma Macroscopic and Microscopic Extent of tumor: - Skin: Skin is not present - Skeletal muscle: No skeletal muscle present Ductal Carcinoma In SItu (DCiS): - DCIS is present UUI0:F59530A5-7370-4E77-9099-9F38825A38EB *Size (Extent) of DCI$: Representing 10% of tumoral surface TCGA-EW-A1PE-01A-PR Redacted Architectural Patterns: Cribriform Nuclear Grade: Grade iI (intermediate) Necrosis: Present, central (expansive "comedo" necrosis) Lobular Carcinoma IN Situ (LCIS): - Not identified. Histologic Type of Invasive Carcinoma: - Invasive micropapillary carcinoma Histoiogic Grade: Nottingham Histologic Score Glandular (Acinar)Tubular Differentiation: Score 3 Nuclear Pieomorphism: Score 2
+
+--- Page 2 ---
+SURGICAL PAtHOL Report Mitotic Count:  Score 1 Overall Grade: Grade 2: score of 6 Margins: - Margins uninvolved by invasive carcinoma - Distance from closest margin: 4 mm (anterior) - Margins uninvolved by DCiS: - Distance from closest margin: 10 mm (anterior) Treatment Effect: Response to Presurgical (NeoadJuvant) therapy: - In the Breast: No known presurgical therapy - In the Lymph Nodes: No known presurgical therapy Lymph-Vascular Invasion: PRESENT *Dermal Lymph-Vascular Invasion: No skin present Lymph Nodes: - Number of sentinel lymph nodes examined: 0 - Total number of lymph nodes examined (sentinel and Nonsentinel): 23 - Number of lymph nodes with macrometastases (>0.2 cm): 1 - Number of lymph nodes with micrometastases (>0.2 mm to 0.2 cm and /or >200 cells): 0 - Number of lymph nodes with isolated tumor cells (s0.2 mm and s200 ceils): 0. - Size of largest metastatic deposit (if present): 2.5 mm *Extranodal Extension: Not identified Pathologlc Staging (pTNM) - Primary Tumor: pT1c - Regional Lymph Nodes: pN1a - Distant Metastasis: Not applicable Ancillary Studies:d Estrogen Receptor: - Performed on another specimen: ; Results: Immunoreactive tumor cells present (1%). Progesterone Receptor: - Performed on another specimen: ; Results: Immunoreactive tumor cells present (1%). Her2: - Performed on another specimen: ; Results: Nogative AJCC classification (7t ed) pT1c, pN1a, pMn/a NOTE: Som' imm Aistoshemicg! antibocks arr analyle wecific reagens (ASRs) valdated by ow iaborasory. Thex ASRs are clinically wsefwl indicators thas do no: regudre FDA approva. hese clons ore used: 1D5-ERPR636-PRA43=HER2H-EGFR.A histochemmical stains are used wih formalin or molecwlar fixed. parajin embedded tisue. Detection is by Envision Method. Thdresults ore reod by a pathologist as positive or negalive As the attending pathologist, I attest that I: (i) Examined the relevpns preparation(s) for the specimen(s); and (ii) Rendered the diagnosis(es). ***Electronically Signed Out By*** Clinical History: None Provided Operation Performed Left breast lumpectomy with axillary node dissection Pre Qperative Dlagnosis: Breast cancer, female Specimen(s) Received:d A: Left breastlump mass (1 sttich superior, 2 stitches lateral, 3 stitches deep). B: Left axillary contents Page 2 of 3
+
+--- Page 3 ---
+SURGICAL PATHOL Report Gross Description: A. Received in formalin is a 180 gram 11.5 x 7.5 x 3.5 cm left lumpectomy specimen without wire guide.The $pecimen is. oriented with one stitch superior, two stitches lateral and three stitches deep. Resection margins are inkedlas follows:. Superior blue, inferior green, medial red, lateral orange, deep black, anterior yellow. On serial section throygh the  specimen, there is a tan-white ill-defined indurated mass with infiltrating borders that measures 2.0 x 2.0 x 15 cm. This. mass is present at 0.6 cm from the anterior margin, 2.0 cm from the superior margin, 2.2 cm from the infericr margin, 2.4 cm from the deep margin, 3.8 cm from the lateral margin and 2.7 cm from the medial margin. An area of tan-white The breast fibrosis Is present adjacent to the mass. This area measures 2.8 x 2.0 x 2.0 cm. No other lesions are identified.. parenchyma has a fat to stroma ratio of 80-20. Sections submitted as follows:. Anterior margin (ciosest) 2 Inferior margin 3 Superior and deep margin. 4 Lateral and deep margins. 5-8 Lesions submitted in toto 9  Representative section of fibrotic area adjacent to lesion. B. Received in formalin is a segment of tan-yellow fibroadipose tissue, measuring 13.0 x 11.0 x 4.0 cm. Examination of the. specimen reveals multiple possible lymph nodes, measuring up to 2.4 cm. Sections submitted as follows: 1-7 One lymph node bisected per cassette 8 Four lymph nodes per cassette. 9-12 Three lymph nodes per cassette. MD  Page 3 ot 3
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diff --git a/output/text/f59b4ccd-126f-49d5-a082-e8aa980769ff.txt b/output/text/f59b4ccd-126f-49d5-a082-e8aa980769ff.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f8b20b6bc2d3f1369e8716fbfe36098908befbca
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@@ -0,0 +1,15 @@
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+--- Page 1 ---
+Clinical Diagnosis & History: Palpab'le breast mass, FNA positive malignant cells. UUID:CE2FF4D3-B82C-443S-AE1C-3E2E6F104271 TCGA-AO-A036-01A-PR Redacted Specimens Submitted: 1: sp: Sentinel node #1 level one left axilla(fs) 2: SP:  Sentinel node #2 level one left axills ifs) : 3: SP: Non sentinel lymph node left axilla 4: SP: Sentinel node #3, level one left axilla (fs) 5: SP: Left breast mass DIAGNOSIS: 1) LYMPH NODE, SENTINEL #1 LEVEL I LEFT AXILLA; EXCISION: - ONE BENIGN LYMPH NODE, (O/1). - ADDITIONAL H/E STAINED SECTIONS AND IMMUNOHISTOCHEMICAL STAINS FOR CYTOKERATINS (AE1:AE3) SHOW NO EVIDENCE OF METASTATIC TUMOR. 2) LYMPH NODE, SENTINEL #2 LEVEL 1 LEFT AXILLA; BXCISION: - ONE BENIGN LYMPH NODE, (0/1). - ADDITIONAL H/E STAINED SECTIONS AND IMMUNOHISTOCHEMICAL STAINS FOR CYTOKERATINS (AB1:AE3) SHOW NO EVIDENCE OF METASTATIC TUNOR. 3) LYMPH NODE, NON-SENTINEL LEFT AXILLA; EXCISION: ONE BENIGN LYMPH NODE, (O/1). - BENIGN FIBROADIPOSE TISSUE AND NERVE. 4) LYMPH NODE, SENTINEL #3 LEVEL 1 LEFT AXILLA; BXCISION: - ONE BENIGN LYMPH NODE, (O/1). - ADDITIONAL H/E STAINED SECTIONS AND IMMUNOHISTOCHEMICAL STAINS FORS CYTOKERATINS (AE1:AE3) SHOW NO EVIDENCE OF METASTATIC TUMOR. 5) BREAST, LEFT; EXCISION: - INVASIVE DUCTAL CARCINOMA, NOS TYPE, POORLY DIFFERENTIATED,S ASSOCIATED WITH PROMINENT INFLAMMATORY INFILTRATE, HISTOLOGIC GRADE III/III (SLIGHT OR NO TUBULE) FORMATION). NUCLEAR GRADE III/III (MARKED VARIATION IN SIZE AND SHAPE), MEASURING 4.5 CM IN ** Continued on next page ** 1cs-0 -3 Site: brsst Nos c5v.9 hw i01521u _DISCU 1o /29f H!
+
+--- Page 2 ---
+LARGEST DIMENSION GrossLy. - AN IN SITU COMPONENT IS NOT IDENTIFIED. - CALCIFICATIONS ARE PRESENT FOCALLY IN BENIGN BREAST PARENCHYMA. - NO VASCULAR INVASION IS NOTED. - THE MARGINS OF RESECTION ARE NEGATIVE FOR CARCINOMA, (SEE NOTE). NEAREST (POSTERIOR) MARGIN HAS A CLEARANCE OF O.7CM MICROSCOPICALLY. THE - THE SKIN IS NOT INVOLVED BY CARCINOMA. - THE NON-NEOPLASTIC BREAST TISSUE SHOWS FIBROADENOMATOID AND BIOPSY SITE CHANGES. - IMMUNOHISTOCHEMICAL STAINS WERE PERFORMED ON FORMALIN-FIXED TISSUE WITH THE FOLLOWING RESULTS FOR INVASIVE CARCINOMA (BLOCK 5 T 8): ESTROGEN RECEPTOR (6F11, 0 % NUCLEAR STAINING PROGESTERONE RECEPTOR (1E2;) 0 % NUCLEAR STAINING HER2 (HERCEPTEST; NEGATIVE (0) (0% OF INVASIVE TUMOR CELLS EXHIBIT COMPLETE MEMBRANOUS STAINING; UNIFORMITY OF STAINING: ABSENT; HOMOGENEOUS, DARK CIRCUMFERENTIAL PATTERN: ABSENT) CONTROLS ARE SATISFACTORY.S COMMENT: HERCEPTESTTM HER2 PROTEIN OVEREXPRESSION IN BREAST CANCER TISSUE ROUTINELY PROCESSED FOR IS AN FDA-APPROVED METHOD FOR ASSESSMENT OF HISTOLOGICAL EVALUATION. THE HER2 TEST RESULTS ARE REPORTED IN ACCORDANCE WITH THE ASCO/CAP GUIDELINE RECOMMENDATIONS FOR HER2 TESTING IN BREAST CANCER (J CLIN ONCOL 2007; 25(1):118-145). NOTE:  SLIDE 5-L-12 REVIEWED AT DAILY INTRADEPARTMENTAL CASE REVIEW CONFERENCE I ATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL), AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. * Report Blectronically Signed Out *** Special Studies: Result Special Stain Comment RECUT Gross Description: MD 1). The specimen is received fresh for frozen section consultation, labeled ** Continued on next page **
+
+--- Page 3 ---
+"Sentinel node number 1, level 1, left axilla" and consists of a single pink -- Page 3 of 5 tan fatty lymph node measuring 1.8 entirely submitted for frozen section.. cm in greatest dimension. Bisected and Summary of sections: Fsc -- frozen section control 2). The specimen is received fresh for frozen section consultation, labeled "Sentinel node #2, level one, left axilla" and consists of a single pink tan fatty lymph node measuring 1.6 cm in greatest dimension. entirely submitted for frozen section. Bisected and Summary of sections: Fsc -. frozen section control. 3).The specimen is received in formalin, labeled "non-sentinel lymph nodes, left axilla" and consists of fibroadipose tissue and potential lymph nodes ranging from 0.4 to 2.2 cm in greatest dimension. nodes are submitted.  All identified lymph Summary of sections: LN potential lymph nodes BLN-- bisected iymph nodes 4). The specimen is received fresh for frozen section consultation, labeled "Sentinel node #3, level one, left axilla" and consists of a single pink tan fatty lymph node measuring 1.1 cm in greatest dimension. entirely submitted for frozen section.  Bisected and Summary of sections: Fsc -- frozen section control 5.) The specimen is received fresh, labeled "Left breast mass, short stitch superior, long -- lateral" and consists of a 14 x 9 x 4.9 cm, piece of fibrofatty breast tissue with an overlying of 12.5 x 1.3 x 0.2 cm wrinkled tan-pink skin ellipse. A short stitch indicates the superior margin, and a medial - 3.0 x 3.0 cm well-circumscribed, firm, focally hemorrhagic, tan-white Serial sectioning reveals a 4.5 x Stellate mass located 0.7 cm from the posterior closest margin of excision. Sectioning through the remaining breast tissue reveals an abundant amount of dense white fibrous tissue with a moderate amount of yellow, lobulated adipose.  The inferior, medial and lateral margins are shaved and entirely submitted separately.  Perpendicular sections of the superior, anterior and posterior margins are submitted. Representative sections of the tumor and ** Continued on next page **
+
+--- Page 4 ---
+the remaining tissue are submitted.. page Summary of sections:. Sp - superior margin (perpendicular). - inferior margin M  medial margin - lateral margin anterior margin (perpendicular)  posterior margin (perpendicular) tumor Summary of Sections: Part 1: SP: Sentinel node #1 level one left axilla(fs) Block Sect. site 1 PCs FSC 1 Part 2: SP: Sentinel node #2 level one left axilla (fs). Block Sect. site PCs 1 Fsc 1 Part 3:  SP: Non sentinel lymph node left axilla. Block Sect. site 2 PCs bln 1 1n 2 1 Part 4: SP: Sentinel node #3, level one left axilla (fs). Block Sect. site 1 PCs {not entered} Part 5: 1 SP: Left breast mass. Block Sect. site 1 PCs AP 3 1 1 5 1 Pp Sp 1 1 2 3 ** Continued on next page.
+
+--- Page 5 ---
+Intraoperative Consultation: Page 5 of 5 Note: The diagnoses given in this section pertain only to the tissue sample '. examined at the time of the intraoperative consultation. 1) FROZEN SECTION DIAGNOCTC. SP: SENTINEL NODE #1 LEVEL ONE LEFT AXILLA(FS) BENIGN PERMANENT  DIAGNOSIS: SAME 2) FROZEN SECTION DIAGNOSIS: LEFT AXILLA (FS) SP: SENTINEL NODE #2 LEVEL ONE BENIGN PERMANENT DIAGNOSIS: SAME 4) FROZEN SECTION DIAGNOSIS: LEFT AXILLA (FS) SP: SENTINEL NODE #3, LEVEL ONE BENIGN PERMANENT DIAGNOSIS: SAME MD Note: The diagnoses given in this section pertain only to the tissue sample examined at the time of the intraoperative consultation. 1) FROZEN SECTION DIAGNOSIS: LEFT AXILLA(FS) SP: SENTINEL NODE #1 LEVEL ONE BENIGN PERMANENT DIAGNOSIS:  SAME 2) FROZEN SECTION DIAGNOSIS: LEFT AXILLA (FS) SP: SENTINEL NODE #2 LEVEL ONE BENIGN PERMANENT DIAGNOSIS:  SAmE 4) FROZEN CWCTION DIAGNOSIS: LEFT AXILLA (FS) SP: SENTINEL NODE #3, LEVEL ONE BENIGN PERMANENT DIAGNOSIS: SAME * End of Report
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diff --git a/output/text/f5cee32c-a438-4de9-8579-f6c863bd3935.txt b/output/text/f5cee32c-a438-4de9-8579-f6c863bd3935.txt
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index 0000000000000000000000000000000000000000..3790120b9b758e85ead9ca6e9a61ec615d4795ec
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+TCD-O-3 ereenomo 1 sguomsua, cel NOS 807013 Sate : Eosphago, distal Hhugl UUID:E984A958-58F7-42DD-9B75-51147814701B TCGA-VR-A8ER-01A-PR C165 ath AtO n/24[y Collect date: (MM/DD/YYYY) PRIMARY SITE: Esophagus PATHOLOGY REPORT: 1. Specimen: thoracic and abdominal esophagus and proximal stomach. Procedure: Esophagogastrectomy Tumor site: distal esophagus and stomach Tumor size (greatest dimension): 7,8 cm Histologic type: Squamous cell carcinoma, ulcerated Histologic grade: G2 moderately differentiated Microscopic tumor extension: tumor invades mucosa, submucosa, muscularis propria and adventitia Lymph-vascular invasion: not identified Perineural invasion: not identified Margins: Proximal margin: uninvolved by carcinoma Distal margin: uninvolved by carcinoma Circumferential (radial margin): involved by invasive carcinoma Regional lymph nodes from lesser curvature with conglomerate: Number examined: 08 Number positive for neoplasia: 03 2. "Lymph nodes of the hepatic artery": Number examined: 06 Number positive for neoplasia: 00 3. "Margin of the stomach': Uninvolved by carcinoma Q43
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diff --git a/output/text/f6034f59-dacf-4a35-8b06-3e53c5aaa2c8.txt b/output/text/f6034f59-dacf-4a35-8b06-3e53c5aaa2c8.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3c653be06c094223c407fde29833c58a279a5bf5
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+
+--- Page 1 ---
+Patient ID: Surgical Date: Gross Description: There is an esophagus fragment up to 9 x 5 cm in its size, with a grey-white tumor up to 6.5 cm in its size, with superficial ulceration.. Microscopic Description: Squamous cell carcinoma of the esophagus, keratinizing sub-type, G-1 (pT2),. with ulceration. Two paraesophageal lymph nodes were examined. One of them demonstrated  metastasis. Another one demonstrated lipomatosis. Eight lymph nodes along the a. gastrica sinistrae  were examined. One of them demonstrated metastasis. All other lymph nodes demonstrated anthracosis, follicular hyperplasia.. Diagnosis Details: Tumor Features: Ulcerated, Tumor Extent: Muscularis Propria, Venous Invasion: Absent, Margins: Absent, Treatment Effect:. tcD-o-3 Comments: erstnry 807i13 Formatted Path Reports: ESOPHAGUS TISSUE CHECKLIST Ste Dstol thusl Specimen type: Esophagectomy Issphaeyss C15. Tumor site: Esophagus. tJ 7/s/13 Tumor size: 0 x 0 x 6.5 cm Histologic type: Squamous cell carcinoma, keratinizing. UUID:02D2F724-69E1-4BA7-A9C2-5406BA92536F TCgA-IG-A6QS-01A-PR Redacted Histologic grade: Well differentiated. Tumor extent: Muscularis propria. Lymph nodes: 2/10 positive for metastasis (Paraesophageal (2), along the a. gastrica sisnistr 2/10) Lymphatic invasion: Not specified. Venous invasion: Absent. Margins: Uninvolved Evidence of neo-adjuvant treatment: No Additional pathologic findings: tumor location; lower third of esophagus. tumor features: ulcerated Comments: None
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diff --git a/output/text/f64a7dbe-eea4-41fd-a4f4-dac33f7a5b6b.txt b/output/text/f64a7dbe-eea4-41fd-a4f4-dac33f7a5b6b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..59ac9e969bbdcc5e9390436c34a51ac42359ae30
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+
+--- Page 1 ---
+tcDo-3 Sute Yrair,nyeatentoriD Hs C7L0 QJ 8/2/13 0 ma+iOu mica9\&>cu(aF pwli] NO keCo7i7 aud no 1p/194 C07) No Diaquo>7 Auupla,fic Ashocyfomu WlfO qucaI UUID:481CC0B0-251F-436D-9330-A79BE8358686 TCGA-S9-A6WM-01A-PR Redacted full rcpor Untransla+ed houSed at twe Bcr is
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diff --git a/output/text/f655ebdc-f556-45bc-a046-6a2fdf871a6b.txt b/output/text/f655ebdc-f556-45bc-a046-6a2fdf871a6b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..475402c1d29cc347390daa0e47a650d5491db2ab
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+
+--- Page 1 ---
+Patient: Referring Physician:. DOB: Age: Gender:F Ref: Hosp#: Provider Group : Date of Service: Case Date Received: Date Reported: A copy of this ranart will be faxed to:. ulilbstro Arsinono duet uos FINAL SURGICAL PATHOLOGY REPORT C50.9 Diagnosis: ypn -tnnes Aadisr C8.2 A. - C.) LEFT BREAST, ADDITIONAL ANTERIOR MARGIN, AND LEFT AXILLARy SENTINEl LYMPH NODE SIMPLE MASTECTOMY (INCLUDING RE-EXCISION OF ANTERIOR MARGIN) AND SENTINEL NODE BIOPSY: - Invasive ductal carcinoma, Nottingham grade 3. UUID:302E69E0-39F0-4CDB-97F9-A6CDDB3D7233 TCGA-AC-A6IW-01A-PR Redacted - Size: 2.6 cm in greatest dimension. - Location: 11:00. - No in situ component identified. - Margins: - Invasive carcinoma is widely free of all margins (at least 1 cm away). - Additional anterior margin consists of benign skin and subcutaneous tissue. - No Iymphovascular invasion identified.. - Two sentinel lymph nodes, negative for carcinoma (0/2). - Uninvolved breast parenchyma with focal fibroadenomatoid changes. - Benign skin and nipple with small intraductal papilloma. COMMENT: Breast carcinoma biomarker studies will be repeated on a representative section of tumor (block A7) due to the focal weak to strong reactivity for ER and PR in <1% tumor cells seen previously on core biopsy. The results will follow in an addendum. PATHOLOGIC TUMOR STAGING SYNOPSIS: Type and grade (invasive): Invasive ductal carcinoma, Nottingham grade 3. Type and grade (in situ): N/A. Primary tumor: pT2. Regional lymph nodes: pN0(i-)(sn). Distant metastasis: N/A. Stage: IIA. Lymphovascular invasion: Not identified. Margin status: R0, negative. Case # Page 1 Printed: This report continues... (FINAL) Page 1/6 Page 1
+
+--- Page 2 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT Invasive Breast Cancer Tumor Staging Information AJCC Cancer Staging Handbook, 7th Ed., and CAP Protocol (revised June 2012).  Previous pathology specimens Case #: Page 2 Printed: This report continues... (FINAL) Page 2/6 Page 2
+
+--- Page 3 ---
+Patient: Case #: SPECIMEN IDENTIFICATION Simple mmastectomy with re-excision of anterior. Procedure/specimen type: margin. Left breast. Laterality: Sentinel lymph node biopsy. Lymph node sampling: INVASIVE CARCINOMA TUMOR CHARACTERISTICS Invasive ductal carcinoma. Histologic type 11:00. Tumor site: 2.6 cm in greatest dimension. Turnor size: Tumor focality: Unifocal. 3 of 3 (Nottingham score 9 of 9). Histologic grade (Nottingham Score): Tubule formation: 3 of 3. 3 of 3. Nuclear pleomorphism: 3 of 3. Mitotic rate: Not identified. Lymphovascular invasion: Benign skin and nipple. Macroscopic and rnicroscopic extent of tumor:. Not identified. DUCTAL CARCINOMA IN SITU (DCIS): MARGINS Widely free of all margins (at least 1 cm away).. Invasive carcinoma: LYMPH NODES 2 (sentinel nodes). Total lymph nodes examined 0. Number of lymph nodes involved N/A. Size of largest metastatic deposit: Extranodal extension: N/A. PATHOLOGIC STAGING: pT2. Primary Tumor (pT): pNO(i-)(sn). Regional lymph nodes (pN): N/A. Distant metastasis (pM): AJCC Stage: IIA. ANCILLARY STUDIES: Negative (less than 1% positive cells, weak. Estrogen receptor: intensity) Negative (less than 1% positive cells, strong Progesterone receptor: intensity) Negative (score 0). HER2: High (70% positive cells). Ki-67: Page 3 Case #: This report continues... (FINAL) Printed: - Page 3 Paae 3/6
+
+--- Page 4 ---
+Patlent: Case #: FINAL SURGICAL PATHOLOGY REPORT Signed by Source of Specimen: A. Breast;left B. Sentinel lymph node;left axillary C. Breast;left additional anterior margin Clinical History/Operative Dx: Malignant neoplasm of breast (female, left) Intraoperative Diagnosis: B. Left axillary sentinel lymph node : No tumor cells identifies Gross Descriptlon: A. Part A Is designated as left breast - stitch = lateral. Initially received in the fresh state for possible is an 862 gram left simple mastectomy, 26.8 cm mediallateral, 20.8 cm inferior-superior, and 4.0 cm posterior-anterior. The overlying ellipse of wrinkled, tan-brown skin is 26.3 x 13.0 cm with a medial-inferior orientated, darkened brown, wrinkled areola, 4.8 cm in diameter with a prominent 1.3 cm nipple. A double suture marks the lateral apex of the skin. A palpable mass is appreciated in the upper inner quadrant (approximating 11:00). The surgical margins are now differentially inked as follows: Superior superficial: Blue, Inferior superficial: Orange, Posterior: Black. Included within the container are two unoriented strips of wrinkled, tan-brown skin measuring 11.7 x 2.7 x 0.7 cm and 10.3 x 2.4 x 1.3 cm each. Case #: Page 4 Printed: This report continues... (FINAL)  Page 4/6 Page 4
+
+--- Page 5 ---
+Patient: Case FINAL SURGICAL PATHOLOGY REPORT The breast is serially sectioned perpendicularly through the media-lateral long axis to reveal a well-demarcated, soft to rubbery, light gray, lobulated tumor mass measuring upwards of 2.6 x 2.5 x 2.3 cm (siabs 6-7, from medial). This tumor is placed grossly 1.0 cm from the superior superficial, 2.4 cm from the deep and greater than 5.0 cm from the inferior superficial, most medial and most lateral surgical margins. Along the medial periphery of the lesion is an embedded twisted radiologic marker. The remaining cut sections of the breast demonstrates admixed yellow-tan fibrofatty tissue without additional discrete nodularity. No lymph node tissue is appreciated along the lateral periphery. Sectioning through the remaining two strips of skin demonstrate unremarkable fibrofatty cut surfaces. Representative sections are submitted. Cassette summary:. A1) nipple, A2) medial and lateral extension of skin, A3) upper inner quadrant, slab 3, A4) upper inner quadrant, slab 5, adjacent to tumor, A5) upper inner quadrant, tumor and superior superficial surgical margin, slab 6,. A6-A7) upper inner quadrant, tumor and superior superficial surgical margin, contiguous sections, slab 6, A8) upper inner quadrant, deep margin adjacent to tumor, slabs 6-7,. A9) upper inner quadrant-central superior, adjacent to tumor, slab 8,. A10-A11) lower inner quadrant, slabs 4 and 6, respectively, A12-A13) lower outer quadrant, slabs 9 and 11, respectively. A14-A15) upper outer quadrant, slabs 9 and 11, respectively. A16-A17) representation of separate strips of skin and subcutaneous fat, two pieces each B. Part B is left axillary sentinel lymph node (frozen section). Initially received in the fresh state for frozen section/touch prep analysis is a 6.0 x 3.0 x 1.0 cm pad of yellow-tan fatty soft tissue. Initial sectioning reveals a single fatty pink and tan lymph node candidate, 2.0 cm in greatest dimension. Two touch preparation slides are forwarded for microscopic evaluation. Further examination of the fat reveals possible additional lymph node tissue up to 1.0 cm in greatest dimension. The largest lymph node is entirely submitted for routine histology with a sentinel node protocol performed in B1 and B2, and the  additional/residual lymph node tissue candidacy is submitted in B3 and B4 for routine histology. C. Part C is additional anterior margin - left. Initially received in the fresh state is a 15 gram elliptical excision of wrinkled , tan-brown skin and subcutaneous fat, 11.1 x 2.6 x 1.5 cm. The margins are submitted unoriented; the possible outer margin is now marked blue and the remaining surgical margins are marked black. Sectioning demonstrates glistening, admixed yellow-tan fibrofatty tissue without discrete nodularity or grossly unusual areas of change suggestive of residual or invasive tumor component. Representative section are submitted for microscopic evaluation in C1-C5 (six pieces Microscopic Description: A. - C.) Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis cytokeratin immunostain. rendered. The sentinel nodes (part B) were evaluated by H&E levels and. Controls are appropriate. Page 5 Case #: This report continues... (FINAL) Printed: Page 5 Page 5/6
+
+--- Page 6 ---
+Patient: Case #: FINAL SURGICAL PATHOLOGY REPORT Case #: Printed: Page 6 END OF REPORT (FINAL) Page 6/6 Page 6
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diff --git a/output/text/f6610f41-de93-44ea-93cb-d5ef2d69514c.txt b/output/text/f6610f41-de93-44ea-93cb-d5ef2d69514c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fa33294702a17566c0e757c8229e2661c0297ae9
--- /dev/null
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@@ -0,0 +1,12 @@
+
+--- Page 1 ---
+UUID: FFA6F9F3-71C1-4AF9-B9F7-0466550EBC90 TCGA C-A80Q-01A-PR Redacted Referring Physician:. DOB Age: Gender:F Ref#: Hoso# Date Reported:  A copy of this report will be faxed to: FINAL SURGICAL PATHOLOGy REPORT Diagnosis: A. -C.) RIGHT BREAST AND AXILLARY SENTINEL LYMPH NODES, LUMPECTOMY WITH SENTINEL LYMPH NODE BIOPSIES (X2): - Invasive ductal carcinoma, Nottingham grade 3.. - Tumor size: 3.8 cm in diameter. - Ductal carcinoma in situ (Dcis), high nuclear grade, solid type, yith. comedo necrosis and calcifications.. - Dcis is present in association with invasive carcinoma, at the periphery of the  main tumor mass, does not extend significantly beyond the atea of invasion, and comprises less than 10% ofltumor volume. - Lumpectomy margins are free of tumor. - Carcinoma is located 0.3 cm from deep margin, and is at least 0.5 cm from. all other margins. - Metastatic carcinoma identified in one of two sentinel Iymph nodes (the involved Iymph node is sentinel lymph node with count 414).. - The metastatic focus measures 1.2 cm in diameter; no extranodal extension. is identified.. - Metastatic carcinoma comprises approximately 40% of the inyolved Iymph node volume. PATHOLOGIC TUMOR STAGING SYNOPSIS: Type and grade (invasive): Invasive ductal carcinoma, Nottingham grade 3. Type and grade (in situ): DCiS, nuclear grade 3. IcDO 3 Primary tumor: pT2. Regional Iymph nodes: pN1a. Distant metastasis: Not applicable.. 85gl3 Stage: IIB. Site: YuastNoS Lymphovascular invasion: Present.. 569 Margin status: Negative (R0). 1]-z|14f Breast Invasive Tumor Staging Information Case #: Page 1 Printed: This report continues... (FINAL) Patient Nam Pathology Repo
+
+--- Page 2 ---
+Case # Specimen type: Panial breasl. Specimen procedure: Lumpectomy. Lymph node sampling: Sentinel lymph nodes. Specimen integrity: Intact specimen. Specimen lateraliy: Right. Specimen size: 6.5 x 5.5 x 4.5 cm. :  INVASIVE TUMOR FEATURES: Invasive tumor size: 3.8 cm. Invasive tumor sile: Upper-outer quadrant. Invasive tumor focality: Single focus. Histologic type: invasive ductat carcinoma. Total Nottingham Grade: 30f3. Tubule formation: 3 0f 3. Nuclear Pleomorphism: 3 0f 3. Mitotic count for Nottingham: 3 of 3. Mitotic count: Twenly-four milose$ in ten high power fields. Lymphatic invasion: Present :  MARGIN STATUS FOR INVASIVE COMPONENT: Negative (RO). Distance of lumor from margins:. 0.3 cm. Closest margin: Deep. Other margins: All other margins are at least 0.5 cm from tumor.. IN-SITU CARCINOMA (DCIS) FEATURES: OCIS extent: Comprises iess than 10% of tumor volume;. DCIS identified only in area ol invasive carcinoma. Pattern: Solid. Nuclear grade: High grade. Necrosis: Present. Calcificatlons: Present.: Margin status for DCiS component:. Negative! Distance of In-situ from neares! nargin:. At teast 0.5 cm. LO8ULAR CARCINOMA IN-SITU (LCIS):E Absent. Skin: Not applicable. Nipple: Not applicable. Skeletal Muscle: Not applicabte. INVASIVE PATHOLOGIC TUMOR STAGING (pTNM)E Primary lumor (pT): pt2. Regional lymph nodes (pN): pN1a. Case #  Page 2 Printed: This report continues... (FINAL) Pathology Repor.
+
+--- Page 3 ---
+Case # FINAL SURGICAL PATHOLOGY REPORT Distant metastasis (pM): Not applicable. RECEPTOR STATUS AND HER2/NEU: Estrogen receptors: Progesterone receptors: 0% postlive cells. 0% positive cells. Her2/neu: 1+. Ki-67 proliferative Index: 70% positive cells.. Source of Specimen: A. Breast lumpectomy;Right Breast B. Sentinel lymph node;Right Breast : C. Sentinel iymph node;Right Breast : Clinical History/Operative Dx: .  Right breast mass/cancer Gross Descriptlon: A. Specimen is labeled right breast lumpectomy. initlly recelved in fresh state for possible tumor bank  studies is a 74 gram portion of yellow-tan fibrofally sof tissue, 4.5 cm anterior-posterior, 5.5 cm superior-inferior, 8.5 cm medlal-tateral. Three sets of sutures are present designated as,follows: a double Tong designated inferior, a single long designated medial, a double shont designated anterior. The  margins are now differentially inked. The specimen is senially sectioned perpendicularly through the  medlal-laterat long axis to reveal a partially well demarcated dense gray-tan tymor mass measuring. 0.6 cm of the superior, 0.8 cm of the anterior, 1.0 cm of the lateral and 1.2 cm of the infegior surgical.  margins. The cut surfaces surrounding the tumor mass are lobular, admixed yellow-tan yithout additional. discrete nodularty. Representative sections are submitted in a sequential fashion, lateral towards medial. Cassette summary:  A1-A2) slab 1, aleral margin Page 3 Printed: This repost continues... (FINAL)  Pathology Repor!e
+
+--- Page 4 ---
+Case #: FINAL SURGICAL PATHOLOGY REPORT A3) slab 2, posterior anterior margins. A4) slab 2, superior inferior margins A5) siab 2, bulk of tumor A6) siab 3. posterior anterior margins, tumor A7) slab 3, superior inferior margins, tumor A8) slab 3, bulk of tumor A9) slab 4, posterior margin. A10) slab 5, posterior anterior margins A11) slab 5, superior interior margins A12) slab 5, bulk of tumor. A13) slab 6. posterior anterior A14) slab 6, superior inferior margins A15) slab 6, bulk of tumor A16-A17) slab 7, medial margin, tumor  SUPERIOR: BLUE MEDIAL: RED ANTERIOR: YELLOW INFERIOR: GREEN LATERAL:ORANGE  POSTERIOR: SLACKE B. Specimen is labeled sentinel node , right breast. Received in formalin is a rubbery pink and tan lymph node candidate 1.3 x 1.1 x 0.7 cm. The margins are now routinely marked blue:/The specimen is  Serially sectioned demonstrating a rubbery pink and tan cul surface without grossly disgrete nodularity. The lymph node is entiraly submitted for microscopic evaluatlon in B1, with a sentinel lymph node protocol performed. C. Specimen is labeled sentinel node : . right breast. Received in formalin is a 3.0. 2.3 x 2.0 cm  portion of fal. Examination reveals a 2.0 x 1.6 x 1.3 cm lymph node. The margins are ngw marked blue. The specimen is serially sectioned, revealing a predominantly nodular dense gray-lan qul surface with  peripheral sortened pink and tan appearance. The lymph node is entirely submitied formicroscopic evaluation in C1 and C2, with a sentinel lymph node protocol performed. Microscopic Description: A. Microscopic sections have been examined. The microscopic findings are ?eflected In'the diagnosis rendered. B. Microscopic sections have been examined. The microscopic findings are refected inthe dlagnosis rendered. C. Microscopic secllons have been examined. The microscopic findings are reflecled inthe dlagnosis rendered. Case # Page 4 Printed: END OF REPORT.. (FINAL) Patient Nam Pathology Repo DISQUAL
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diff --git a/output/text/f68848b3-ea40-4f72-8103-8927bfb13c8a.txt b/output/text/f68848b3-ea40-4f72-8103-8927bfb13c8a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fdbaaad8a7466aad366bf95997caaecab03bda82
--- /dev/null
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@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TCGA-BO-4707 FINAL DIAGNOSIS PART 1: Cystic wall, eXciSion- A.  FIBROVASCULAR TISSUE LINED BY CUBOIDAL AND COLUMNAR EPITHELiUM, CONSISTENT WITH BENIGN Cyst. B.  NO EVIDENCE OF NEOPLASIA IS SEEN. PART 2: KidnEy, Right, Larger UppER POLe TumOr, parTIal NEpHrecTOmy -  RENAL CELL CARCINOMA, CONVENTIONAL (CLEAR CELL) TYPE WITH CYSTIC CHANGES. B.  FUHRMAN NUCLEAR GRADE IS II OF IV, . C. THE GreateSt D!ameter Of The nEOpLASm iS 4.7 cm. D.  NO EVIDENCE OF ANGIOLYMPHATIC INVASION IS IDENTIFIED. E. All SurgiCal margins Are frEE OF THe NeOplASm. F. THE NON-NEOPLASTIC KIDNEY IS UNREMARKABLE. G. TNM STAGE: pT1b NX MX. PART 3: KiDney, RIght, SmAllEr.uppEr pOle-tumor, parTIal Nephrectomy - A. RENAL CELL CARCINOMA, CONVENTIONAL (CLEAR CELL) TYPE WITH CYSTIC CHANGES. B. FUHRMAN NUCLEAR GRADE IS II OF IV. C. THE GREATESt DiAmETeR Of THE NEOPLASm IS 2.1 cm. D.  NO EVIDENCE OF ANGIOLYMPHATIC INVASION IS IDENTIFIED. E. ALL SURGICAL MARGINS ARE FREE OF THE NEOPLASM. F. THE NON-NEOPLASTIC KIDNEY IS UNREMARKABLE. G. TNM STAGE: pT1a NX MX. PART 4: FAT OVERLYING MIDPOLE TUMmOR, EXCISION- A.  MATURE ADIPOSE TISSUE WITH NO FOCAL HEMORRHAGE. B. NO EVIDENCE OF CARCINOMA IS SEEN. pArt 5: KIDNEy, RIGHT, MID POLE TUmOR, PARTIAL NEPHRECTOMy - A.  RENAL CELL CARCINOMA, CONVENTIONAL (CLEAR CELL) TYPE WITH CYSTIC AND MYXOID CHANGES. FUHRMAN NUCLEAR GRADE IS II OF IV. C.  THE GREATEST DIAMETER OF THE NEOPLASM IS 4.1 cm.  NO EVIDENCE OF ANGIOLYMPHATIC INVASION IS IDENTIFIED. E. THE CARCINOMA FOCALLY EXTENDS TO THE INKED CAPSULAR RESECTION MARGIN (SLIDE 5C). THE PARENCHYMAL SURGICAL MARGINS IS FREE OF THE NEOPLASM. F. THE NON-NEOPLASTIC KIDNEY IS UNREMARKABLE. G. TNM STAGE: pT1b NX MX. PArT 6: KIDnEy, LEFt, RADiCaL NepHRECTOmY - H.  RENAL CELL CARCINOMA, CONVENTIONAL (CLEAR CELL) TYPE WITH EXTENSIVE NECROSIS, HEMORRHAGE AND SARCOMATOID FEATURES INCLUDING FOCAL RHABDOID MORPHOLOGY (See COmment). I. FUHRMAN NUCLEAR GRADE IS IV OF IV. J. THE GREATEST DIAMETER OF THE NEOPLASM IS 10.2 cm. K. THE CARCINOmA EXTeNDS TO THE RENAL SInUS fAT (SLiDE 6E). THE NEOPLASM IS CONFINED WITHIN THE RENAL CAPSULE. M. NO INVASION OF THE RENAL VEIN IS IDENTIFIED. N. FOCI SUSPICIOUS FOR ANGIOLYMPHATIC INVASION ARE IDENTIFIED. ALL SURGICAL MARGINS ARE FREE OF THE NEOPLASM. P. THE NON-NEOPLASTIC KIDNEY IS UNREMARKABLE. Q.  LEFT ADRENAL WITH NO SPECIFIC PATHOLOGIC CHANGES. R. TNM STAGE: pT3a NX MX.
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diff --git a/output/text/f69c42cb-f191-4417-8d1e-fb73f3c819b9.txt b/output/text/f69c42cb-f191-4417-8d1e-fb73f3c819b9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..bc6a57d3609a1c48c6bb4ee2eb4878184873adc8
--- /dev/null
+++ b/output/text/f69c42cb-f191-4417-8d1e-fb73f3c819b9.txt
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+
+--- Page 1 ---
+UUID:E6F4C8E3-78E6-4E23-9812-F13879C29896 'TCGA-MH-A561-01A-PR Redacted SURGICAL PATHOLOGY MEDICAL RECORD  SURGICAL PATHOLOGY PATHOLOGY REPORT A. BASE OF TUMOR FROM LEFT KIDNEY, FSA B. LEFT RENAL MASS *+* SUPPLEMENTARY REPORT HAS BEEN ADDED *+* *+* REFER TO BOTTOM OF REPORT *+* BRIEF CLINICAL HISTORY: PREOPERATIVE DIAGNOSIS: Renal Mass OPERATIVE FINDINGS: POSTOPERATIVE DIAGNOSIS: Renal Mass PATHOLOGY REPORT GROSS DESCRIPTION: A. Received fresh from the operating room for intraoperative consultation is 0.5x0.5x0.1 cm irregular fragment of soft tissue. entirely submitted in cassette FsA. FROZEN SECTION DIAGNOSIS FSA. LEFT KIDNEY, BASE OF TUMOR, FROZEN SECTION - NO MALIGNANCY SEEN B. Received is a 10.9 gram, 4.1 x 2.8 x 2.5 cm, partial nephrectomy specimen displaying a tan-brown, scabrous renal resection margin..  The capsule margin is tan-white and smooth with minimal attached fat. The specimen is inked blue along the renal resection margin, black along the capsular resection margin, and serially sectioned to reveal a 1.8 x 1.8 x 1.8 cm, tan-yellow, well-circumscribed mass that grossly. extends to the capsular surface. resection margin. The remaining cut surface is tan-brown and unremarkable.  No subsequent lesions are identified. The specimen is submitted in its entirety sequentially in cassettes B1-b7. Please note that a representative portion of normal and tumor is taken for tissue. MICROSCOPIC EXAM FINAL DIAGNOSIS IcD-o 3 A. LEFT KIDNEY, BASE OF TUMOR, FROZEN SECTION BENIGN KIDNEY PARENCHYMA - NO TUMOR SEEN 8260/3 B. KIDNEY, LEFT, PARTIAL NEPHRECTOMY Site,DKdrey NOS - PAPILLARY RENAL CELL CARCINOMA, TYPE 1, GRADE 1 (See cancer case summary and comment) C64.9 - TUMOR LIMITED TO KIDNEY JtO zl1s/3
+
+--- Page 2 ---
+Surgical Pathology Cancer Case Summary Based on AJcc/uIcc TNm, 7th edition Procedure: Partial nephrectomy Specimen Laterality: Left Tumor Site: Lower pole. Tumor Size: 1.8 cm Tumor Focality: Unifocal. Macroscopic Extent of Tumor: Tumor limited to kidney. Histologic Type: Papillary renal cell carcinoma Sarcomatoid Features: Not identified. Tumor Necrosis: Not identified - Histologic Grade: Grade 1 - Microscopic Tumor Extension: Tumor limited to kidney. - Margins: Margins uninvolved by invasive carcinoma Lymph-Vascular Invasion: Not identified. Pathologic Staging: pTla, pNx, pMx. Pathologic Findings in Nonneoplastic Kidney:. CHRONIC PYELONEPHRITIS Comment: Additional sections pending to determine capsule invasiviness will be reported in an addendum.. SUPPLEMENTARY REPORT(S) : Supplementary Report Date:. *+* SUPPLEMENTARY REPORT HAS BEEN ADDED/MODIFIED *+* (Added/Last released: ADDITIONAL FINDINGS - KIDNEY, LEFT, PARTIAL NEPHRECTOMY - PAPILLARY ADENOMA - NO CAPSULAR INVASION IDENTIFIEDS Comment: Multiple additional section were examined. The rest of the  diagnosis remains unchanged. PATHOLOGIST (End of report). w Case (rcic) V.
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diff --git a/output/text/f69e8656-1be1-484c-b20d-e4ef3bb54f87.txt b/output/text/f69e8656-1be1-484c-b20d-e4ef3bb54f87.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e3cb7ad75939d9fbf81026c5fdb13d6ad6a1393a
--- /dev/null
+++ b/output/text/f69e8656-1be1-484c-b20d-e4ef3bb54f87.txt
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+
+--- Page 1 ---
+UUID:A7F1EA5C-5797-42D1-AD35-E2E529B26409 TCGA-LG-A6GG-01A-PR Redacted Surgical Pathology Report DATE OBTAINED: DATE RECEIVED: DATE REPORTED: CC: DIAGNOSIS IcD O-3 #1- RESECTION, LIVER (SEGMENT 3): HEPATOCELLULAR CARCINOMA- hyposteelbusor Nos Corenomo, 8l70/3 Tumor type: Hepatocellular carcinoma Sit:dier  C qq.D Histologic grade: Moderately differentiated; nuclear grade (II) Tumor size: 8.5cm. Tumor multifocality: J e11z/3 Unifocal Vascular invasion:  Microvascular invasion (focal) Hepatic capsule: Negative (1.8 cm); subcapsular hemorrhage Local extension: Confined to the liver Margins: Hepatic parenchymal transsection margin- negative (tumor-1.5 cm from staple line.  margin) Lymph nodes: Not present Other findings:  Micronodular cirrhosis pT2 NX AJCC stage: Stage II ***Electronically Signed Out**** COMMENT 88309, 88331x2 Clinical Diagnosis and History:. Liver tumor Tissue(s) Submitted:  SEGMENT 3 LIVER LESION Gross Description: The specimen is received fresh for intraoperative consultation labeled with patient name designated segment 3 liver lesion and. consists of a 292 gram, 11.5 x 8.0 x 6.5 cm intact segment of liver with a single stapled margin. The capsular surface is red brown,.  intact and shaggy. The resection margin is inked and the specimen is serially sectioned to reveal an 8.5 x 7.0 x 5.5 cm soft tan  brown well defined mass measuring 1.5 cm from the stapled margin with surrounding dark red subcapsular hemorrhage. The  uninvolved liver parenchyma is tan brown and granular. No other discrete lesions are identified. Representative sections are submitted as follows: 1AFS: soft tissue frozen section remnant 1BFS:  mass frozen section remnant Page 1 of 2
+
+--- Page 2 ---
+Surgical Pathuiogy keport 1C-1E:mass to margin 1F-1H:mass to subcapsular hemorrhage 1-1J: mass Intraoperative Consult Diagnosis 1A/FSDX: GROSS RESECTION MARGIN NEGATIVE (1.8 CM TUMOR TO MARGIN); HEPATOCELLULAR CARCINOMA <211 SQUALITIL Page 2 of 2 END OF REPORT
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diff --git a/output/text/f6b44b15-7bce-46a5-ad75-d42196d5a441.txt b/output/text/f6b44b15-7bce-46a5-ad75-d42196d5a441.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b5bb7a8b4289bd14c4b02fea08b0e76552ea3504
--- /dev/null
+++ b/output/text/f6b44b15-7bce-46a5-ad75-d42196d5a441.txt
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+
+--- Page 1 ---
+SURGICAL PATHOLOGY REPORT * Final Report Document Type: UUID:907112FF-1E09-4BD1-97BE-01E9BAC0E4D9 *Date - Date of Service: TCGA-XF-AAMR-01A-PR Redacted Document Status: Document Title: Author: Authenticated By: Encounter info: Contributor system: * Final Report * INTRAOPERATIVE GROSS CONSULTATION E: Bladder and prostate: I00 0.3 all margins are negative 'Qrnome wrstulal NtS 812c1d INTRAOPERATIVE FROZEN CONSULTATION: AFS: Right distal ureter:  no tumor identified Carcencme) tranoitionol cesI N6S 81zof3 BFS: Left distal ureter:. Sute : YBlaslolr postrrwall C67.4  no tumor identified CFS:  Additional right ureter: QO3/2 6|14  no tumor identified DFS: Apical urethral margin:  no tumor identified GROSS EXAMINATION: A: The specimen is received fresh from the O.R. and labelled "Right distal ureter". ~It consists of a segment of ureter that measures 0.4 x 0.4 x 0.2 cm. The specimen is entirely submitted for frozen section in cassette AFs.. B:  The specimen is received fresh from the O.R. and labelled "Left distal ureter". It consists of a 0.4 x 0.4 x 0.2 cm segment of ureter with surrounding fat. The specimen is entirely submitted for frozen section in cassette BFs.. C: The specimen is received fresh from the O.R. and labelled "Additional right ureter F/s". It consists of 1 x 0.5 x 0.5 cm segment of right ureter with surrounding fat.  The specimen is entirely submitted for frozen section diagnosis. in cassette cFs. Printed by: Page 1 of 8 Printed on: (Continued)
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT * Final Report *. D: The specimen is received fresh from the O.R. and labelled "Apical urethral margin-F/s". It consists of a 1 x 0.3 x 0.2 cm soft brown-tan tissue fragment. The specimen is entirely submitted for frozen section in cassette Drs. E: The specimen is received fresh from the O.R. and labelled "bladder and prostate".  It consists of a prostatectomy specimen with an overall measurement of 34 x 13 x 4.2 cm. The peritoneum measures 28 x 16 x 3 cm. The bladder itself measures 9 x 9 x 2 cm. The peritoneum is not involved by tumor. Attached to the. bladder is a segment of right ureter that measures 4 cm in length and 2.5 cm in circumference and a left ureter measuring 3 cm in length and 1 cm in circumference. The prostate measures 4.7 x 4 x 3.5 cm. The right seminal vesicle measures 2.5 x. 1.5 x 0.5 cm and the left seminal vesicle measures 3.5 x 2 x 1 cm. The outer surface of the specimen is inked black..  Opening the specimen anteriorly reveals a. prostatic urethra that measures 3.7 cm in length and 3.6 cm in circumference. The verumontanum measures 1 x 1.2 x 0.3 cm.  The right posterior bladder mucosa, at the area of the right ureterovesical junction, shows 4 x 4 cm gray-tan ulcerated lesion with necrotic surface.  Sectioning of the ulcerated lesion shows a mass that. invades through the entire wall thickness of the urinary bladder and extends into the perivesical fat. At the request of the surgeon, an intraoperative pathologic consultation is performed in order to aid in the care of this patient. Representative sections are submitted in 26 cassettes. F: The specimen is received in formalin and labelled "Left para aortic L.N.". It consists of a 3 x 1.5 x 1 cm soft brown-tan tissue fragment. One lymph node is identified. The specimen is entirely submitted in three cassettes. G: The specimen is received in formalin and labelled "Right para caval L.N.". It consists of a 3 x 1 x 0.5 cm soft brown-tan fibrofatty tissue fragment. One lymph node that measures up to o.7 cm in greatest dimension is identified. The specimen is entirely submitted in two cassettes. H: The specimen is received in formalin and labelled "Right common iliac L.N.". It consists of a 3 x 2 x 1 cm soft brown-tan fibrofatty tissue fragment. Two lymph. nodes ranging in size from 0.6 to 2.7 cm are identified. The specimen is entirely submitted in two cassettes. I:  The specimen is received in formalin and labelled "Left common iliac L.N." It consists of a 2 x 2 x 1 cm aggregate of multiple soft brown-tan fibrofatty tissue fragments. Three lymph nodes are identified ranging in size from 0.2 to 1.2 cm in greatest dimension. The specimen is entirely submitted in three cassettes. J: The specimen is received in formalin and labelled "Right external iliac L.N.". It consists of a 2 x 2 x 1 cm aggregate of multiple soft yellow-tan fibrofatty tissue fragments. Six lymph nodes are identified ranging in size from 0.2 to 0.8 Printed by: Page 2 of 8 Printed on: (Continued)
+
+--- Page 3 ---
+SURGICAL PATHOLOGY REPORT * Final Report * cm in greatest diameter. The specimen is entirely submitted in three cassettes. K: The specimen is received in formalin and labelled "Right L.N. of cloquet". It consists of a 1 x 1 x 0.8 cm soft brown-tan fibrofatty tissue fragment. One lymph node that measures up to 1.3 cm in greatest dimension is identified. The specimen is entirely submitted in one cassette.. L: The specimen is received in formalin and labelled "Right obturator hypogastric L.N.". It consists of a 4 x 3 x 1.5 cm aggregate of multiple soft yellow-tan fibrofatty tissue fragments. The specimen is entirely submitted in five cassettes. M: The specimen is received in formalin and labelled "Left L.N. of cloquet". It consists of a 1.3 cm lymph node. The specimen is entirely submitted in one N: The specimen is received in formalin and labelled"Left external iliac L.N.". It consists of a 2 x 2 x 0.5 cm aggregate of soft yellow-tan fibrofatty tissue fragments. The specimen is entirely submitted in one cassette. O: The specimen is received in formalin and labelled "Left obturator hypogastric L.N.". It consists of a 5 x 3 x 1 cm soft yellow-tan fibrofatty tissue fragment. The specimen is entirely submitted in five cassettes.. P: The specimen is received in formalin and labelled"Right pre sciatic L.N.". It consists of a 1.5 x 1 x 0.3 cm aggregate of multiple soft brown-tan fibrofatty tissue fragments. identified. The specimen is entirely submitted in one cassette. Q: The specimen is received in formalin and labelled "pre sacral L.N.". It consists of a 4 x 2 x 0.5 cm soft brown-tan fibrofatty tissue fragment. Four lymph nodes are identified ranging in size from 0.3 to 0.6 cm in greatest diameter. The specimen is entirely submitted in four cassettes.. R:  The specimen is received in formalin and labelled "Left pre sciatic L.N.". It consists of a 0.5 x 0.5 x 0.2 cm aggregate of multiple soft yellow-tan fibrofatty tissue fragments. The specimen is entirely submitted in one cassette. S: The specimen is received in formalin and labelled "Left proximal ureter". It consists of a portion of ureter that has three metallic staples. The specimen measures 1.5 x 1 x 0.2 cm. The specimen is serially sectioned and entirely submitted in one cassette. T: The specimen is received in formalin and labelled "Right proximal ureter". It consists of a portion of ureter .The specimen is entirely submitted in one Cassette. Printed by: Page 3 of 8 Printed on: (Continued)
+
+--- Page 4 ---
+SURGICAL PATHOLOGY REPORT * Final Report * SECTIONS: AFs: frozen section, right distal ureter BFs: frozen section, left distal ureter cfs : frozen section additional right ureter DFs: frozen section, apical urethral margin E1: apex of prostate E2 : right ureter margin E3 : left ureter margin E4 : right ureterovesical junction E5: left ureterovesical junction E6: trigone and bladder neck E7: dome E8-12: ulcer E13: ulcer adjacent to right ureter E14: ulcer E15: right distal prostate E16: left distal prostate E17: right mid prostate E18: left mid prostate. E19: right proximal prostate E20 : right seminal vesical junction. E21: left proximal prostate E22 : left seminal vesical junction. F1: left para-aortic lymph node; lymph node F2,3: remaining tissue G1: right paracaval lymph node; lymph node G2 : remaining tissue H1: right common iliac lymph node; lymph node H2 : remaining tissue I1: left common iliac lymph node; lymph node 12,3: remaining tissue J1,2: right external iliac lymph node; lymph nodes J3 : remaining tissue K: right lymph node of cloquet - all embedded L1: right  obturator hypogastric lymph node; two possible lymph nodes L2-4 : one trisected lymph node L5: remaining tissue M: left lymph node of cloquet; one lymph node N : left external iliac lymph node - all embedded. 01: left obturator hypogastric lymph node; three lymph nodes. 02-4 : one trisected lymph node 05: remaining tissue P: right presciatic lymph node - all embedded Q1: presacral lymph node; lymph nodes Printed by: Page 4 of 8 Printed on:. (Continued)
+
+--- Page 5 ---
+SURGICAL PATHOLOGY REPORT * Final Report * Q2~4 : remaining tissue R: left presciatic lymph node - all embedded s: left proximal ureter- all embedded T: right proximal ureter - all embedded Signature Line CLINICAL INFORMATION: Pre-op Dx: Bladder Cancer Post-Op Dx: Same SPECIMEN SOURCE: "Right distal ureter" B: "Left distal ureter" C: "Additional right ureter F/S" D: "Apical urethral margin-F/s". E: "bladder and prostate" F: "Left para aortic L.N." G: "Right para caval L.N." H: "Right common iliac L.N." I: "Left common iliac L.N." J: "Right external iliac L.N." K: "Right L.N. of cloquet" L: "Right obturator hypogastric L.N." M: "Left L.N. of cloquet" N: "Left external iliac L.N." O: "Left obturator hypogastric L.N." P: "Right pre sciatic L.N." Q: "pre sacral L.N." R: "Left pre sciatic L.N." S: "Left proximal ureter" T: "Right proximal ureter" DIAGNOSIS: RADICAL CYSTECTOMY WITH T-POUCH TO URETHRA: RIGHT DISTAL URETER (A) : INTRAOPERATIVE FROZEN DIAGNOSIS:  NO TUMOR IDENTIFIED FINAL DIAGNOSIS: Printed by: Page 5 of 8 Printed on: (Continued)
+
+--- Page 6 ---
+SURGICAL PATHOLOGY REPORT * Final Report * BENIGN URETER NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIEDS LEFT DISTAL URETER (B) : INTRAOPERATIVE FROZEN DIAGNOSIS: NO TUMOR IDENTIFIED FINAL DIAGNOSIS: BENIGN URETER NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIEDS ADDITIONAL RIGHT URETER (C) : INTRAOPERATIVE FROZEN DIAGNOSIS:  NO TUMOR IDENTIFIED FINAL DIAGNOSIS:  BENIGN URETER NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED APICAL URETHRAL MARGIN (D) : INTRAOPERATIVE FROZEN DIAGNOSIS: NO TUMOR IDENTIFIED FINAL DIAGNOSIS: BENIGN URETHRAL AND PERIURETHRAL TISSUE NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED BLADDER, PROSTATE AND BILATERAL PERIVESICAL LYMPH NODES (E) : INTRAOPERATIVE GROSS DIAGNOSIS: ALL MARGINS ARE NEGATIVE FINAL DIAGNOSIS: BLADDER: TRANSITIONAL CELL CARCINOMA (4 X 4 CM). GRADE 3/4, INVADING THROUGH MUSCULARIS PROPRIA AND INTO PERIVESICAL SOFT TISSUE TUMOR INVOLVES AND OBSTRUCTS THE RIGHT URETEROVESICAL JUNCTION AND EXTENSIVELY INVOLVES RIGHT POSTERIOR BLADDER WALL TUMOR DOES NOT INVOLVE THE PROSTATE BILATERAL URETER, APEX AND RADIAL MARGINS OF SPECIMEN ARE NEGATIVE FOR TUMOR PROSTATE: PROSTATIC ADENOCARCINOMA, GLEASON'S SCORE 6 (3+3), MICROSCOPICALLY INVOLVING RIGHT DISTAL AND MID PROSTATE NO CAPSULAR INVOLVEMENT IDENTIFIED APICAL AND RADIAL INKED SURGICAL MARGINS ARE NEGATIVE BILATERAL SEMINAL VESICLES, NEGATIVE FOR TUMOR MULTIFOCAL HIGH GRADE PROSTATIC INTRAEPITHELIAL NEOPLASIA Printed by: Page 6 of 8 Printed on: (Continued)
+
+--- Page 7 ---
+SURGICAL PATHOLOGY REPORT * Final Report * LEFT DARA AORTIC LYMPH NODES (F) : NO MALIGNANCY IDENTIFIED IN 10 LYMPH NODES EXAMINED (0/10) RIGHT PARACAVAL LYMPH NODES (G) : NO MALIGNANCY IDENTIFIED IN THREE LYMPH NODES EXAMINED (O/3) RIGHT COMMON ILIAC LYMPH NODES (H) : NO MALIGNANCY IDENTIFIED IN THREE LYMPH NODES EXAMINED (O/3) LEFT COMMON ILIAC LYMPH NODES (I) :  NO MALIGNANCY IDENTIFIED IN SIX LYMPH NODES EXAMINED (O/6) RIGHT EXTERNAL ILIAC LYMPH NODES (J) : NO MALIGNANCY IDENTIFIED IN 11 LYMPH NODES EXAMINED (O/11) RIGHT LYMPH NODE OF CLOQUET (K) :  NO MALIGNANCY IDENTIFIED IN TWO LYMPH NODES EXAMINED (O/2) RIGHT OBTURATOR / HYPOGASTRIC LYMPH NODES (L): NO MALIGNANCY IDENTIFIED IN 11 LYMPH NODES EXAMINED (O/11) LEFT LYMPH NODE OF CLOQUET (M):  NO MALIGNANCY IDENTIFIED IN ONE LYMPH NODE EXAMINED (O/1) LEFT EXTERNAL ILIAC LYMPH NODES (N) :  NO MALIGNANCY IDENTIFIED IN TEN LYMPH NODES EXAMINED (0/10) LEFT OBTURATOR / HYPOGASTRIC LYMPH NODES (O) : NO MALIGNANCY IDENTIFIED IN EIGHT LYMPH NODES EXAMINED (O/8) RIGHT PRESCIATIC LYMPH NODES (P) :  NO MALIGNANCY IDENTIFIED IN FIVE LYMPH NODES EXAMINED (O/5) PRESACRAL LYMPH NODES (Q): NO MALIGNANCY IDENTIFIED IN SEVEN LYMPH NODES EXAMINED (O/7) LEFT PRESCIATIC LYMPH NODES (R) : BENIGN FIBROADIPOSE TISSUE NO LYMPHOID TISSUE OR MALIGNANCY IDENTIFIED (O/O) LEFT PROXIMAL URETER (S): BENIGN URETER  NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED RIGHT PROXIMAL URETER (T) : Printed by: Page 7 of 8 Printed on: (Continued)
+
+--- Page 8 ---
+SURGICAL PATHOLOGY REPORT * Final Report * HYDROURETER  NO UROTHELIAL DYSPLASIA OR MALIGNANCY IDENTIFIED LYMPH NODE SUMMARY: NO MALIGNANCY IDENTIFIED IN TOTAL OF 77 LYMPH NODES EXAMINED (0/77) PATHOLOGIC TNM STAGE: BLADDER : pT3bN0MX PROSTATE: pT1aNOMX Signature Line Electronically signea by Verified: Printed by: Page 8 of 8 Printed on: (End of Report)
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diff --git a/output/text/f6f625f2-1a29-4b39-bc6c-28277ba79e35.txt b/output/text/f6f625f2-1a29-4b39-bc6c-28277ba79e35.txt
new file mode 100644
index 0000000000000000000000000000000000000000..3a69baa5a2c3f5bdf75dfe30a9e4ce01a23e0bb4
--- /dev/null
+++ b/output/text/f6f625f2-1a29-4b39-bc6c-28277ba79e35.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+UUID:01727F86-5A8C-4324-BDA4-E47DD7629C19 TCGA-LN-A8I1-01A-PR Redacted IRB APPROVED Clinical Case Report (For Collection of Cancerous Tissue) ICD 0:3 Ceuinnd, sjursus csQ niOS 8070/3 Ste. Cssphrogo NB cis.9 nyhaguo, mdslle ttuol Informed Consent C i5.4 Js11/2o113 I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator  Signature Date Clinical Information GENERAL INFORMATION Date of Birth (mm/dd/yyyy) Height  Marital Status Race Temperature  Single Married NIETNAMESE Gender Weight  Divorced  Widow  Blood Pressure Heart Rate  Maie Female 120 HISTORY OF PRESENT ILLNESS Symptoms: We{ght lcgy Clinical Findings: Performance Scale (Karnofsky Score):  100 Asymptomatic  80-90 Symptomatic but Fully Ambulatory   60-70 Symptomatic, in bed less than 50% of day  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden  20-30 Bed Ridden CURRENT MEDICATIONS Drug Dose Route Frequency Date (mm/dd/yyyy) To To To To ! To
+
+--- Page 2 ---
+PAST MEDICAL HISTORY Diagnosis/Disease/Disorder/Injury Diagnosis Date Treatment Status OB/GYN HISTORY  Menopausal Status Date of First Menses # of Pregnancies  Pre-menopausal feau al e 0 3  Peri-Menopausal Date of Last Menses # of Live Births 02  Post-menopausal fesz gls Birth Control:  Condom  Oral Contraceptive DIUD  Hormone Replacement  Other: Therapy: SOCIAL HISTORY Occupation: Environmental Hazards: Smoking History Current Status TYPE Packs/day Duration. When Quit  yes  $PNO yrs (yr) Alcohol Consumption Current Status TYPE Drinks/day Duration When Quit yES qNO yrs (yr) Drug Use Current Status TYPE Frequency Duration When Quit  yeS NO (yrs) (yr) FAMILY MEDICAL HISTORY .:... Relative  Diagnosis Age of Diagnosis LAB DATA Test Result Date Test Result Date HIV Negative  Positive: CEA  Negative  Positive:  Hep B Negative  Positive: CA 15-3  Negative  Positive: Hep C  Negative ..  Positive: CA 19-9  Negative  Positive: AFP  Negative   Positive: PSA  Negative  Positive: Other: Other: Negative  Positive:  Negative  Positive: B/T Cell Markers: 2
+
+--- Page 3 ---
+DIAGNOSTIC STUDIES Study Results Date Ultrasound X-Ray CT MRI Biopsy CLINICAL DIAGNOSIS Preoperative Clinical Diagnosis Location of Suspected Involved Lymph Nodes Location of Suspected Distant Metastasis Clinical Staging Date of Diagnosis T2 No MC Stage: ZLA Treatment Information SURGICAL TREATMENT Procedure Date of Procedure ReSectign Nthe LLnbes Primary' Tumor Organ Detailed Locatlon Size Esepiags He mide Jhir Extension of Tumor Lymph Nodes Description Location of Lymph Nodes # of Lymph Nodes Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Organ  Detailed Location Size  Surgical Staging T 2 M Stage: I  N o NEOADJUVENT THERAPY (Chemo, Radiation, Immuno, Hormonal, or Molecular) Drug/Treatment Dose Route Frequency Date (mm/dd/yyy) To 1 1 To. / To 1 1 1 / To 1 To 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by: - Date: _Time:_ Preserved by: . Date: _Time: SPECIMEN TYPE (# of samples provided) Frozen Paraffin Block Blood/Serum/Plasma Slide Diseased Normal Diseased Normal Diseased  Normal Diseased  Normal 2 2 f 2 Time to LN2 Time to Formalin Time to LN2 12 min 73 min min PATHOLOGICAL DESCRIPTION Primary Tumor Size Organ Extension of Tumor Distance to NAT E x 5 shscm\midle Zhicd cm Lymph Nodes Location # Examined # Metastasized Distant Metastasis Organ Detailed Location Size Pathological Staging pT 2 N o mO Stage:T Notes: 4
+
+--- Page 5 ---
+IrB APpROVED Consolidated Pathology Diagnosis Cell Distribution + Structural Pattern Diffuse + I Streaming Mosaic. Storform  Necrosis Fibrosis Lymohocytic Infutration X Patisading Vascuiar Invasion Cstic Degeneration Clustertzed X Bleeding Alveotar Formation M xoid Change Indian File Psarnmoma/Calcirication SgusnenoLee Adenomatoue Sarcomatous + L nohomatous Scuamoid Cell Glardkaiar cel Round Cel Large Cel Soinde Cell Cell Stratication Fibroblast Smal Cet Keratin Secretion Osteobiast RS Cel/RS Like Desmosome Intracyt. Vacuole Ljpobiast. Inflam. Cel Peart X. Cland formation Myoblast Plasma Cel Celluiar Differentiation: o Weil  Moderate  Poor Nuck S Atypia: 0 I Aniso Nucieosis Hyerchromatism Nuceotar Prominent Mutinucieated Glant Cef Mirotic Activity Nuclear Grade: D,8OZ Dr8% Dz 757 DqtD7 Fina! Pathology Report Histological Diagnosis: Sglsamvous /ell Ca EinAms. Grade: Comments: 1;Mr : ChRonrc lymfhoeleui 1Y Date Director, Research Pathology lw h18[13 a.teyia INTEGRATED REPORT OF FINDINGS BY COLLASORATORS AND Diagnos Discrcecy Prior Mag.ancy Hi Dual/Synchrrnns Case la cirtie Reviewer In
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diff --git a/output/text/f714581d-2579-4069-9854-a1d56313444c.txt b/output/text/f714581d-2579-4069-9854-a1d56313444c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..97ff7305fa36ceb0e1f130ee348288e40b72c99f
--- /dev/null
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+THIS REPORT HAS BEEN AMENDED SUPPLEMENTAL REPORT DIAGNOSIS : (C) FLOOR OF MOUTH MASS, COMPOSITE RESECTION: INVASIVE SQUAMOUS CARCINOMA WITH ADENOID AND SARCOMATOID FEATURES, MODERATELY TO POORLY DIFFERENTIATED, (5.5 CM IN GREATEST DIMENTION), INVADING MUSCLE _AND BONE WITH VASCULAR AND PERINeuRAl InvAsION,Margins of resection free of tumor. involvement. COMMENTELMEAE This report has been amended b to correct the anatomic site for specimen c from "mandible" DIAGNOSIS (A) LEFT SUPRAOMOHYOID NECK DISSECTION: (ieve1 1); 0/2 subdigastric (leve1 2); 0/3 midjugular (leve1 3); 0/1 lower jugular (level 4). (B) RIGHT MODIFIED NECK DISSECTION: METASTATIC SQUAMOUS CELL CARCINOMA IN 1 OF_3 LYMPH NODESS 1/1 subdigastric (leve1 2); 0/1 midjugular (level 3); 0/1 lower jugular (level 4). (c) COMPOSITE RESECTION ANTERIOR MANDIBLE FLOOR OF MOUTH: INVASIVE SARCOMATOID SQUAMOUS CELL CARCINOMA WITH ADENOID KERATINIZING; (5.5 X 3.0 X 1.5 CM) INVADING THROUGH MUSCLE TO UNDERLYING BONE (SEE COMMENT). Page 1 of 2 History Case Pathology Report History Case Pathology File under: Pathology.
+
+--- Page 2 ---
+VASCULAR _AND PERINEURAL INVASION IDENTIFIED. Margins free of tumor. (D) MENTAL SKIN: Skin, no tumor present. (E) RIGHT LOWER LIP: Squamous mucosa, no tumor present. (F) ANTERIOR FLOOR OF MOUTH: Squamous mucosa, no tumor present. (g) BUCCAL MUCOSA, LEFT: Squamous mucosa, no tumor present. (H) RIGHT BUCCAL MUCOSA: Squamous mucosa, no tumor present. (I) TEETH: Teeth, gross diagnosis only. COMMENT A supplemental report will follow for part C to describe the degree of bone inyolvement. SPECIMEN LEFT SUPRAOMOHYOID NECK DISSECTION: B RIGHT MODIFIED NECK DISSECTION: COMPOSITE RESECTION ANTERIOR MANDIBLE FLOOR OF MOUTH: (D) MENTAL SKIN: RIGHT LOWER LIP: ANTERIOR FLOOR OF MOUTH: BUCCAl mucOSA, Left: G (H) RIGHT BUCCAL MUCOSA: Teeth: I SNOMED CODES T-11180,M-80743 Entire report and diagnosis completed by Page 2 of 2  History Case Pathology Report History Case PathoTogy File under: Pathology
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diff --git a/output/text/f72b7c90-4b16-4340-8432-eb25f1025db6.txt b/output/text/f72b7c90-4b16-4340-8432-eb25f1025db6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..314b081b536cdb7829dd0c8704ef4fc582d4546a
--- /dev/null
+++ b/output/text/f72b7c90-4b16-4340-8432-eb25f1025db6.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+OOPHORECTOMY-BI, COLECTOMY-RIGHT GROSS DESCRIPTION A. The specimen is submitted fresh as "right colon" and consists of a segment of large bowel removed in continuity with cecum and terninal ileum. The proximal and distal margins are joined with a line of metallic staples. The ileal segment measures 4.5 cm in length and 1.5 an in diameter at the partially stapled proximal margin. The colonic segment including cecum measures 13 cm in length and 2 cm in diameter at the partially stapled distal margin. The serosa is pink with a scant amount of membranous adhesions and a moderate amount of pericolic fat. There is puckered 2.5 cm area at the cecal pouch. The vermiform appendix is not rossly identified. The lumen contains a small amount of hemorrhagic fecal material. The mucosal surfaces are pink tan with the usual folds and a large nodular 6.5 x3.5 x 2.5 cm tumor which fills the cecal pouch. The tumor is firmly fixed to the underlying muscularis and corresponds to the puckering previously described.The radial mesenteric margin measures 9 cm in length. Sectioning reveals the tumor to infiltrate nearly the entire thickness of the bowel wall approaching O.1 cm of the inked (black) serosa. There are two small sessile tan 0.2 cm nodules at a distance of 1l and 5 cm from the distal margin of resection.Also noted is a O.6 cn area of submucosal hemorrhage at a distance of 3 cm from the distal margin. Examination of the attached adipose tissue reveals sixteen moderately firm to firm pink and pale white nodules ranging 0.3 to l.5 cm in greatest dimension. Representative sections are submitted,multiple 10)labeled asfollows: Cassette 1: Margins (proximal margin green dye,distal margin blue dye) Cassettes 2-5: Tumor deep margin black) Cassette 6: Sessilepolyp Cassette.7: Submucosal hemorrhage Cassettes 8-10: Nodules found in the attached pericolic fat Please note: A portion of tissue is collected for TcGA studies.
+
+--- Page 2 ---
+B. The specimen is submitted fresh as "right ovary" and consists of a segment of fallopian tube with attached ovary The fallopian tube includes the fimbria and measures cm in length and 0.3 cm in diameter. There is a O.4 cm plastic ligation ring at the proximal margin. The lumen is patent. The ovary measures 3 x 3 x 3 cm. The external surface is yellow white and lobulated. Sectioning reveals multiple serous cysts with a smooth lining ranging 0.3 to 1.5 cm in greatest dimension and a firm 2 cm pink white whorled nodule. Representative sections are submitted,9 (6) 1abeled "1 to 6. C. The specimen is submitted fresh as "left ovary" and consists of a segment of fallopian tube with attached ovary The fallopian tube is stretched across the ovarian surface and includes the fimbria measuring 6 cm in length and 0.3 cm in diameter. The ovary lobulated with membranous adhesions. Secti.oning reveals a multiloculated serous cyst with a smooth lining and a small O.7 cm area of tan papillary projections. Representative sections are submitted, multiple (6) labeled 1to6 FINAL DIAGNOSISASMA RIGHT COLON (HEMICOLECTOMY MODERATELY DIFFERENTIATED ADENOCARCINOMA ARISING IN A TUBULO- VILLOUS ADENOMA6.5 CM TUMOR INVADES INTO BUT NOT ENTIRELY THROUGH MUSCULARIS PROPRIA WITH EXTENSION TO O.2 CM FRCM ANTIMESENTERIC SEROSAL SURFACE. SEE COMMENT. RADIAL MESENTERIC MARGIN MEASURES 9 CM. SEPARATE TUBULAR ADENOMATA ARE IDENTIFIED AT 5 AND 11 CM FROM DISTAL MARGIN OF RESECTION O.2 CM EACH) ALL SURGICAL MARGINS AND SIXTEEN REGIONAL LYMPH NODES,NEGATIVE FOR TUMOR. PATHOLOGIC STAGE:pT2 NO MX COMMENT IN REGION OF MAXIMUM TUMOR DEPTH THE MUSCULARIS PROPRIA IS DISRUPTED BY FIBROUS TISSUE REACTION. TUMOR DOES NOT EXTEND BEYOND MUSCULAR PLANE AND DOES NOT INVOLVE PERICOLONIC ADIPOSE TISSUE. B. RIGHT OVARY, FALLOPIAN TUBE SALPINGO-OOPHORECTOMY): BENIGN CYST- ADENOFIBROMA(2 CMNEGATIVE FOR ATYPIA,SURFACE EPITHELIAL PROLIFERATION, OR FEATURES OF MALIGNANCY.PREVIOUSLY LIGATED FALLOPIAN TUBE WITH FIBROTIC FIMBRIAE. C. LEFT OVARY,FALLOPIAN TUBESALPINGO-OOPHORECTOMY: BENIGN CYST- ADENOFIBROMA 6.5 CM)NEGATIVE FOR ATYPIA,SURFACE EPITHELIAL
+
+--- Page 3 ---
+PROLIFERATION, OR FEATURES OF MALIGNANCY. HISTOLOGICALLY UNREMARKABLE FALLOPIAN TUBE. MSYNOPTIC REPORT SYNOPTIC REPORT: COLON AND RECTUM CAP/AJCC/ACS -REQUIRED ELEMENTS SPECIMEN TYPE: RIGHT HEMICOLECTOMY SPECIMEN SIZE:17.5CM TUMOR SITE:CECUM ffrf TUMOR SIZE: 6.5CM MACROSCOPIC TUMOR PERFORATION:PRESENT HISTOLOGIC TYPE: ADENOCARCINOMA HISTOLOGIC GRADE: MODERATE EXTENT OF INVASION: INTO BUT NOT THROUGH MUSCULARIS PROPRIA OTHER ORGANS INVOLVED/VISCERAL PERITONEUM: NONE ARGINS: PROXIMAL:UNINVOLVED fRADIALUNINVOLVEDfff fLENGTHOFRADIAL MARGIN9 CM fIE MARGINS UNINVOLVEDDISTANCE TO CLOSEST MARGINO.2 CM FROM SEROSAL SURFACE NEOADJUVANT TREATMENT EFFECT: NOT APPLICABLE LYMPHATIC INVOLVEMENT: ABSENT VENOUS (LARGE VESSEL) INVOLVEMENT:ABSENT PERINEURAL INVASION: ABSENT TUMOR DEPOSITS (DISCONTINUOUS EXTRAMURAL EXTENSION):ABSENT LYMPH NODES: f #INVOLVED/#EXAMINED:0/16 OTHER PERTINENT FINDINGS: (SEE NARRATIVE) pTNM STAGEpT2 NO MX
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diff --git a/output/text/f744f6bf-82ee-4a71-9236-2bb12581a615.txt b/output/text/f744f6bf-82ee-4a71-9236-2bb12581a615.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1dfd2d148b7c575e20ba39b05c1be6d58a206657
--- /dev/null
+++ b/output/text/f744f6bf-82ee-4a71-9236-2bb12581a615.txt
@@ -0,0 +1,21 @@
+
+--- Page 1 ---
+UUID:AEC9F6D0-E697-47C8-9654-F0EF52454EF8 Redacted IcD-O-3 sLl eranmo y ngusmouo c Operative Procedure: Glossectomy, neck dissection. Ruabwyng Nds 8071|3 Siti Jngu NoS. C02.9 Specimen Received: A: Right vocal cord biopsy (FS) B: Level 1 neck dissection-left JtJ s/24/1 3 C: Base of tongue at hyoid (FS) D: Distal lingual nerve margin (FS) E: Left lingual artery biopsy (FS) F: Deep tongue base margin #1 (FS) G: Tongue base mucosa margin (FS). H: Anterior mucosa margin (FS). I:  Anterior inferior mucosa margin (FS). J: Posterior medial mucosa margin (FS) K: Deep medial margin (FS) L:  Posterior deep base of tongue (FS) M:  Proximal lingual nerve biopsy (FS) N: Left tongue lesion O: Left neck dissection level 2-4. P: Left neck dissection 2B Final Pathologic Diagnosis: Left tongue, partial glossectomy: Keratinizing squamous cell carcinoma, moderately differentiated. Histologic type/grade: Keratinizing squamous cell carcinoma,  moderately differentiated Tumor size: 3.0 cm (greatest dimension) Depth of invasion:. 0.8 cm (greatest dimension) Lymph-vascular invasion:  Present Perineural invasion: Present Tumor site: Left lateral tongue. Tumor focality: Single focus Margins: Deep surgical margin transected by carcinoma on the resected specimen (frozen section margins are negative). Margins uninvolved by carcinoma in situ. Lymph nodes, extranodal extension: Left level 1-4 lymph node dissection: Metastatic squamous cell carcinoma (5/30 lymph nodes positive, extracapsular spread present, maximal dimension 4.8 cm). Pathologic Staging (pTNM): Primary tumor (pT): pT2 Regional lymph nodes (pN): pN2b M.57
+
+--- Page 2 ---
+Number examined: 30 Number involved: 5 Size of the largest positive lymph node: 4.8 cm (greatest dimension) Distant metastasis (pM): pMX Additional pathologic findings: None Specimen: Tongue, lateral surface Received: In formalin Procedure: Partial glossectomy with left neck dissection levels 1-4 Specimen size: 5.6 x 4.9 x 2.3 cm (greatest dimensions) Specimen laterality: Left A. Right vocal cord biopsy:. Moderate epithelial dysplasia, frozen section diagnosis confirmed B. Level 1 neck dissection, left:. Metastatic squamous cell carcinoma (2/8 lymph nodes positive, maxima! dimension 2.7 cm, no extracapsular spread).. C. Base of tongue at hyoid, biopsy: Detached fragment of squamous cell carcinoma, frozen section diagnosis confirmed. D. Distal lingual nerve margin (FS): No evidence of malignancy, frozen section diagnosis confirmed.. E. Left lingual artery biopsy (FS):  No evidence of malignancy, frozen section diagnosis confirmed. F. Deep tongue base margin #1 (FS): No evidence of malignancy, frozen section diagnosis confirmed. G. Tongue base mucosa margin (FS): No evidence of malignancy, frozen section diagnosis confirmed. H. Anterior mucosa margin (FS): No evidence of malignancy, frozen section diagnosis confirmed. I. Anterior inferior mucosa margin (FS): No evidence of malignancy, frozen section diagnosis confirmed. J. Posterior medial mucosa margin (FS):. No evidence of malignancy, frozen section diagnosis confirmed. No epithelium is present on the frozen or permanent sections. K. Deep medial margin (FS)
+
+--- Page 3 ---
+No evidence of malignancy, frozen section diagnosis confirmed. L. Posterior deep base of tongue (FS): No evidence of malignancy, frozen section diagnosis confirmed. M. Proximal lingual nerve biopsy (FS): No evidence of malignancy, frozen section diagnosis confirmed. N. Left tongue lesion, partial glossectomy: Keratinizing squamous cell carcinoma, moderately differentiated (see Synoptic Report for details). O. Left neck dissection level 2-4: Metastatic squamous cell carcinoma (3/15 lymph nodes positive, maximal dimension 4.8 cm, extracapsular spread present). P. Left neck lymph node dissection levvel 2B: No evidence of malignancy (0/7 lymph nodes positive).. The examination of this case material and the preparation of this report were performed by the staff pathologist. Intraoperative Consult Diagnosis: FSA: Right vocal cord biopsy: Low grade squamous dysplasia with focal moderate dysplasia. F/S TAT:6 mins. FSC: Basal tongue at hyoid: Detached fragment of squamous mucosa with at least mild to moderate dysplasia. Carcinoma in situ cannot be excluded (poor. orientation).. F/S TAT:19 mins. FSD: Distal lingual nerve margin: Negative for tumor. FSE: Left lingual artery biopsy: Negative for tumor. FSF: Deep tongue base margin #1: Negative for tumor. FSG: Tongue base mucosa margin: Mild squamous dysplasia. FSH: Anterior mucosa margin: Negative for tumor. FSI: Anterior inferior mucosa margin: Negative for tumor. FSJ: Posterior medial mucosa margin: Negative for tumor (squamous mucosa not present) FSK: Deep medial margin: Negative for tumor.
+
+--- Page 4 ---
+FSL: Posterior deep base of tongue: Negative for tumor. FSM: Proximal lingual nerve biopsy: Negative for tumor. F/S TAT: 30 mins. Gross Description: The specimen is received in sixteen parts, each labeled with the patient's name Part A received fresh for intraoperative consultation labeled "right vocal cord biopsy" and consists of a 0.2 cm in greatest dimension irregular, gray-tan soft tissue, which has been submitted in toto for frozen section diagnosis and the residue resubmitted for permanent sections in cassette A. Note, it is questionable as to whether this specimen will survive processing.. Part B received in formalin labeled "level 1 neck dissection, left" and consists of a portion of irregular, ragged, focally fragmented, gray-yellow to red-brown,. focally cauterized fibrofatty tissue, which has dimensions of 8.5 x 5.2 x 2.8 cm. The fat contains a gray-yellow, lobulated salivary gland, which has dimensions of 4.8 x 2.7 x 1.6 cm. There are no focal lesions identified within the salivary gland. Sectioning through the remainder of the fat reveals eleven probable lymph nodes that range from 0.4 to 2.7 cm in greatest dimension. The largest lymph node is grossly positive.. Representative sections are submitted as labeled:. B1  salivary gland;. B2 four lymph nodes submitted in toto; B3 one bisected lymph node; B4 one bisected lymph node; B5 a representative section of the largest grossly positive lymph node;. B6 one bisected lymph node; B7 one bisected lymph node; B8 one bisected lymph node; B9 one bisected lymph node. Part C received fresh for intraoperative consultation labeled "base of tongue at hyoid" and consists of three irregular, gray-tan soft tissues, which have. greatest dimensions of approximately 0.3 cm each, which have been submitted in toto for frozen section diagnosis and the residue resubmitted for permanent sections in cassette C. Part D received fresh for intraoperative consultation labeled "distal lingual nerve margin" and consists of a 0.4 cm in greatest dimension irregular gray-tan soft tissue, which has been submitted in toto for frozen section diagnosis and the residue resubmitted for permanent sections in cassette D. Part E received fresh for intraoperative consultation labeled "left lingual artery biopsy" and consists of two irregular, gray-tan soft tissues, which have
+
+--- Page 5 ---
+greatest dimensions of 0.2 and 0.6 cm, which have been submitted in toto for frozen section diagnosis and the residue resubmitted for permanent sections in cassette E. Part F received fresh for intraoperative consultation labeled "deep tongue base margin #1" and consists of a 0.8 cm in greatest dimension irregular, gray-tan soft tissue, which has been submitted in toto for frozen section diagnosis and the residue resubmitted for permanent sections in cassette F. Part G received fresh for intraoperative consultation labeled "tongue base mucosa margin" and consists of two irregular, gray-tan soft tissues, which have greatest dimensions of 0.3 and 0.7 cm, which have been submitted in toto for frozen section diagnosis and the residue resubmitted for permanent sections in cassette G. Part H received fresh for intraoperative consultation labeled "anterior mucosa margin" and consists of three irregular, gray-tan soft tissues, which have greatest dimensions of 0.3, 0.7 and 0.9 cm, which have been submitted in toto for frozen section diagnosis and the residue resubmitted for permanent sections in cassette H. Part I received fresh for intraoperative consultation labeled "anterior inferior mucosa margin" and consists of an irregular, gray-tan soft tissue, which has a greatest dimension of 1.0 cm. The specimen has been submitted in toto for frozen section diagnosis and the residue resubmitted for permanent sections in cassette 1. Part J received fresh for intraoperative consultation labeled "posterior medial mucosa margin" and consists of an irregular, gray-tan soft tissue, which has a greatest dimension of 1.1 cm, which has been submitted in toto for frozen section diagnosis and the residue resubmitted for permanent sections in cassette J. Part K received fresh for intraoperative consultation labeled "deep medial margin" and consists of an irregular, gray-tan soft tissue, which has a greatest dimension of 0.6 cm. The specimen has been submitted in toto for frozen section diagnosis and the residue resubmitted for permanent sections in cassette K. Part L received fresh for intraoperative consultation labeled "posterior deep base of tongue" and consists of three irregular, gray-tan soft tissues, which have greatest dimensions of 0.1, 0.6 and 0.8 cm, which have been submitted in toto for frozen section diagnosis and the residue resubmitted for permanent sections in cassette L. Part M received fresh for intraoperative consultation labeled "proximal lingual nerve biopsy" and consists of a 0.7 cm in greatest dimension irregular, gray-tan soft tissue, which has been submitted in toto for frozen section diagnosis and the residue resubmitted for permanent sections in cassette M.
+
+--- Page 6 ---
+Part N is received in formalin labeled "left tongue lesion" and consists of a  previously inked and incised portion of left tongue, which has dimensions of 5.6 x 4.9 x 2.3 cm. The specimen was initially received fresh with tissue submitted to the Tissue Bank. The deep surface is irregular, gray-brown and focally cauterized. The mucosa is gray-tan and diffusely granular. The lateral border of the tongue is remarkable for an ulceration, which has dimensions of 1.8 x 1.2 cm. This ulceration extends to within 0.2 cm of the nearest inferior lateral mucosal edge. The specimen is further sectioned to reveal a gray-white, granular indurated mass, which has dimensions of 3.6 x 2.2 x 1.3 cm. This mass is contiguous with the aforementioned ulceration. This mass extends to the soft tissue edge at numerous sites. There is some loosely attached soft tissue at the inferior lateral aspect of the specimen, which has dimensions of 3.0 x 2.6 x 0.8 cm. This tissue is sectioned to reveal a gray-tan, lobulated cut surface that is grossly suggestive of salivary gland. Also, the soft tissue is remarkable for focal granularity, fibrosis and induration. These foci are highly suspicious. Representative sections are submitted as labeled:  N1-4 mass to include ulceration and close mucosal edges in cassettes N1 and N2, as well as deep soft tissue edges in. cassettes N3 and N4;. N5 apparent salivary gland; N6 associated soft tissue with suspicious appearing foci Part O received in formalin labeled "left neck dissection level 2-4" and. consists of a portion of irreguiar, ragged, gray-yellow to red-brown, lobulated fibrofatty and fibromuscular tissue, which has dimensions of 11.4 x 4.0 x 1.8 cm. The fat contains 16 probable lymph nodes that range from 0.3 to 4.8 cm in greatest dimension. The largest lymph node is grossly positive. The lymph nodes are submitted as labeled:. 01 six lymph nodes submitted in toto;. 02 three lymph nodes submitted in toto;. O3  five lymph nodes submitted in toto; O4-5  one trisected lymph node; 06  representative section of the largest, grossly positive lymph node. Part P received in formalin labeled "left neck dissection level 2B" and consists of a portion of irregular, ragged, gray-yellow to red-brown, focally cauterized, Iobulated fat, which has dimensions of 2.6 x 2.2 x 0.9 cm. The fat contains eight probable lymph nodes that range from 0.6 to 0.8 cm in greatest dimension. The lymph nodes are submitted in toto in cassettes P1 and P2. Microscopic Description:. Histologic examination reveals a left glossectomy specimen and left neck dissection specimen. The glossectomy specimen is notable for a deeply invasive  keratinizing squamous cell carcinoma exhibiting moderate differentiation. Both perineural and lymphovascular invasion are prominent. The neck dissection demonstrates multiple metastatic nodes, the largest of which is 4.8 cm with extracapsular spread.
+
+--- Page 7 ---
+END OF REPORT Taken: DOB: (Age:  , Gender: F
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diff --git a/output/text/f7c38adb-5ec7-47f6-b594-73cc09745c2c.txt b/output/text/f7c38adb-5ec7-47f6-b594-73cc09745c2c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..7c8ff63c3fd49099a3ee6184b2cb3635df5a32aa
--- /dev/null
+++ b/output/text/f7c38adb-5ec7-47f6-b594-73cc09745c2c.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+IDo-3 Carcinoirc-, adrenab csrtical UUID:23328F06-11F8-4D12-BA95-D5CC9AEFE22A 8370]3 Site;Acdrenal Clard,corHu C 74.D Procedure: L adrenalectomy, nephrectomy, Gross description: 10 x 6.5 x 6.5cm Diagnosis: adrenocortical carcinoma, pT3 pN1 pM1(LYM) L1 V1 Pn0 R0, 52/52 LN positive Reference Pathology: Diagnosis: adrenocortical carcinoma, Kl67 10-20% Weiss score: 4 Hough score: 0.97 Van Slooten score: 12.3 h !u/3
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diff --git a/output/text/f7dbdcce-556c-4c3b-a72b-772f7c984a77.txt b/output/text/f7dbdcce-556c-4c3b-a72b-772f7c984a77.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1e2926ab71931e1d364e6b9a2ed7c5aea610ea30
--- /dev/null
+++ b/output/text/f7dbdcce-556c-4c3b-a72b-772f7c984a77.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+DIAGNOSIS: 1.Renal mass left,#1 resection):Papillary renal cell carcinoma type 1;incipient lesions are present 2.Renal mass, left #2 (resection):Papillary renal cell carcinoma type I incipient lesions are present. NOTE: CLINICAL INFORMATION:Allocate Order to Protocol: 7 Brief Clinical History: Left renal mass Specimen Taken For Protocol -Yes PROcEDuRE: Pre-Operative Diagnosis: Left Renal Mass Post-Operative Diagnosis Left Renal Mass Operative Findings:3 cm left renal mass SPECIMENS SUBMITTED:1.KIDNEY,LEFT,MaSS #1 2.KIDNEY,LEFT,Mass #2 GROss DEsCRIPTION:Received are 2 containers labeled with the patient's name,medical record number,and further described as follows: 1.Tumor #1 is a single solid tan/yellow soft tissue fragment measuring 0.6 x 0.4 x 0.2 cm.Approximately 50% is procured for Research and the remainder is preserved in formalin, The specimen is received in Surgical Pathology and is consistent with the above description. The specimen is wrapped in lens paper entirely submitted in a white cassette labeled 1 for permanent processing Pationt Identification Page 1of2
+
+--- Page 2 ---
+2. "Tumor #2" is a 4.2 x 4.0 x 4.0 soft tissue fragment. The specimen is inked in black and bisected to reveal a tumor with a relatively homogeneous white/yellow, fleshy cut surface. The tumor measures 3.5 x 3.6 x 3.6 cm. Approximately 1.5 x 1.0 x 0.4 cm of the tumor is procured for Research and the remainder is preserved in formalin. The procurement was performed by at The specimen is. Surgical Pathology and is consistent with the above description. The remainder of the specimen is entirely submitted in white cassettes labeled B 2A-2P for permanent processing. No consultants Patient Identification. Page 2 of 2
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diff --git a/output/text/f7fbfc46-38b9-4e31-a9dd-d2249aa51d2b.txt b/output/text/f7fbfc46-38b9-4e31-a9dd-d2249aa51d2b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c74ef9a717f74e1fedcb2a55c614965451692f34
--- /dev/null
+++ b/output/text/f7fbfc46-38b9-4e31-a9dd-d2249aa51d2b.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:ECEF5C94-4177-48A5-B803-AAS78A9058A6 TCGA-NH-A50U-01A-PR Redacted RUN DATE:  RUN TIME: RUN USER: PATIENT: ACCT #: LOC: AGE/SX :  ROOM : REG DR: DOB: BED: STATUS: SPEC #: RECD: STATUS : COLL : TIME IN FORMALIN: 5:27 hrs. CLINICAL INFORMATION: Pre-Op Diagnosis:. Colon CA Remarks: Specimen(s) : A. Liver biopsy B. Right colon /cs-0-3 Adencsrui oms, muciNou, Nos MCROSCOPIC DIAGNOSIS 9480|3 A CORE BIOPSY. LIVER: Site, cdon, eecun C18.0 METASTATIC ADENOCARCINOMA FROM COLON PRIMARY w u1/1 B. COLON. RIGHT. RIGHT HEMICOLECTOMY:S INVASIVE LOW-GRADE ADENOCARCINOMA WITH MUCINOUS DIFFERENTIATION ARISING IN ASSOCIATION WITH TUBULOVILLOUS ADENOMA OF CECUM TUMOR MEASURES 9 CM IN GREATEST DIMENSION AND INVOLVES VISCERAL PERITONEUM 17 REGIONAL LYMPH NODES NEGATIVE FOR METASTATIC CARCINOMA NO ANGIOLYMPHATIC INVASION IDENTIFIED PERINEURAL INVASION PRESENT MARGINS NEGATIVE WITH CLOSEST MARGIN MESENTERIC/RADIAL WHICH MEASURES 5 MM ADDITIONAL FINDINGS: SEPARATE SESSILE SERRATED ADENOMAS APPENDIX WITH PERIAPPENDICEAL CHRONIC INFLAMMATION COMMENT(S) The large mass involving the cecum is an invasive adenocarcinoma with areas of mucinous differentiation noted. While most of the tumor is low grade. there are microscopic foci where the tumor is of a higher histologic grade. The tumor extends into the proximal appendix as well as involves the subserosa of the distal ileum. will be further evaluated for KRas mutation and mismatch repair defect (by IHc). Additional reports will follow.. CAP PROTOCOL FOR THE EXAMINATION OF SPECIMENS FOR PATIENTS WITH PRIMARY CARCINOMA OF THE COLON AND RECTUM Based on AJCC/UICC TNM. 7th Edition. SPECIMEN: Terminal ileum. cecum. appendix. ascending colon. liver. biopsy PROCEDURE: Right hemicolectomy Liver biopsy ** CONTINUED ON NEXT PAGE **
+
+--- Page 2 ---
+PAGE 2 RUN DATE: RUN TIME: RUN USER: (Continued) SPEC #: PATIENT: COMMENT(S) (Continusd) TUMOR SITE: Cecum TUMOR SIZE: Greatest dimension: 9 cm MACROSCOPIC TUMOR PERFORATION: Present HISTOLOGIC TYPE: Adenocarcinoma HISTOLOGIC GRADE: Low-grade MICROSCOPIC TUMOR EXTENSION: Tumor penetrates to the surface of the visceral peritoneum (serosa) Margins uninvolved by invasive carcinoma. MARGINS : Distance of invasive carcinoma from closest margin: 5 mm. mesenteric/radial TREATMENT EFFECT : No prior treatment LYMPH-VASCULAR INVASION: Not identified PERINEURAL INVASION: Present TUMOR DEPOSITS: Not identified PATHOLOGIC STAGING: Primary tumor: pT4a Regional lymph nodes: pN0 Number of lymph nodes examined: 17 Number of lymph nodes involved: 0 Distant metastasis: pM1a GROSS DESCRIPTION: A. Received fresh for frozen section. labeled with the patient's name and "liver biopsy" are several core biopsies of pale. tan and red tissue which range from 0.2 to 1 cm in diameter to 0.1 cm each. submitted in block A for frozen section evaluation.. B. Received fresh for tissue banking labeled with the patient's name and "right colon" is a 15 cm sagment of large bowel. The bowel includes cecum and a 7.5 cm appendix consistent with a right colon.  There is a 13 cm sogment of distal ileum. The bowel has a palpable. 9.0 x 7.0 x 5.0 cm mass associated with the cecum. The distal ileum is focally adhesed to the mass.  The bowel is opened to have an edematous mucosa. There is a focal area of. identifiable fungating tumor at the appendiceal os. Visible tumor is 1.5 cm and is deep within the cecum.  The tumor comes to within l1.0 cm of the distal margin and is approximately 1.5 cm from the ileocecal valve. There is a sessile 0.3 cm polyp within the ascending colon. The polyp is 7.5 cm from the distal margin.  Sectioning of the tumor shows it to bulge beneath the small bowel. The tumor focally involves the wall of the small bowel and possibly to the mucosa. The tumor tracks up the base of the appendix. and there is a large. feted 3.0 cm abscess cavity in the adipose adjacent to the mass and cecum. The tumor appears to involve the cecal serosa. The radial mesenteric fat margin averages 1.0 cm.  The adipose in the region of the cecum and ileocecal valve havs centrally necrotic. tumor-replaced. matted lymph nodes.. Representative sections are sampled as. labeled: B1 proximal margin B2 distal margin B3 sections of appendix to include tip. B4 ileocecal valve B5.B6 sections of mesenteric fat margin. B7 sections of possible polypoid lesions adjacent to ileocecal valve and ** CONTINUED ON NEXT PAGE **
+
+--- Page 3 ---
+RUN DATE: PAGE 3 RUN TIME:  RUN USER: SPEC #: PATIENT: (Continued) GROSS DESCRIPTION: (Continued) small bowel B8 sessile ascending colon polyp B9-B11 tumor pushing from outside beneath small bowel. B12.B13 tumor extending into base of appendix from cacum to include abscess cavity B14.B15 tumor and cecum B16 tumor beneath ileocecal valve adjacent to cecum. B17 tumor extending to cecal serosa B18-B20 sections of cecal adipose with tumor B21.B22 lymph nodes distal to tumor B23 lymph nodes proximal to tumor and mesenteric small bowel fat . section of tumor is sampled for tissue banking. INTRAOPERATIVE CONSULTATION: FROZEN SECTION DIAGNOSIS. LIVER BIOPSY: A. METASTATIC ADENOCARCINOMA CONSISTENT WITH COLORECTAL PRIMARY RESULTS GIVEN TO DR. 'HE OPERATING ROOM AT B. RIGHT COLON: TISSUE PROCESSED FOR TISSUE BANK WITH PORTION OF TUMOR PROVIDED TO TISSUE BANK COORDINATOR HO 1CMEAT Image Picture Copy Error Image Picture Copy Error Signed (signature on file) ** END OF REPORT **
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diff --git a/output/text/f83a3aca-7211-40ea-8f19-587bcea4e3bb.txt b/output/text/f83a3aca-7211-40ea-8f19-587bcea4e3bb.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1c30f4cdab4ff6e21b84c31011cdcfa14d818a40
--- /dev/null
+++ b/output/text/f83a3aca-7211-40ea-8f19-587bcea4e3bb.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+P.23/33 STLEFT MODIFIED RADICAL MASTECTOmy - AINVASiVe DuctAL CArcInOmA, nOTTingham SCOre 3; nUcLeaR GRaDe 3, TUbULeS 3, mITOsiS 3, tOTAl ScOre 9/9. B. TumOR SiZE 5.5 Cm wIth EXTensIVe inTRATumOrAl LymphOcyTic infILtratiOn. C.  Tumor LOcated in The Upper/outer anD Lower/outer QuaDrant. D.  DUCTAL CARCINOMA IN-SITU, NUCLEAR GRADE 3, SOLID AND CRIBRIFORM WITH COMEDO NECROSIS PRESENT ADMIXED WITH TUMOR AND ACCOUNTS FOR 25% OF TUMOR MASS. E.  ANGIOLYMPHATIC InVASION iDENTIFIED. F. POSTERiOR MARGIN Of UPpER/OUTEr AND LOwER/OUTER QUADRAnt FrEe Of TUmOR. CLOSEST MARGIn IS POSTeRiOR mARGin whICh is 0.6 Cm AWAy fROm THE tUmOR. G. Biopsy site changes. H. EstrOgen receptOr is negatIve, prOgesterone receptOr is NegaTive, hEr-zineu is negative (1+) PER CORE BIOPSy I. ATYPICAL DUCTAL EPITHELIAL HYPERPLASIA (8ee comment). J. TEN OF TWENTy-ONE LYmPH NODES WITH METASTATIC CARCINOMA (10/21)WITH EXTRACAPSULAR Spread in one. K.  FiBrOCyStiC ChangeS, WIth Ductal EpItheLial hypERpLAsia AnD ApOcRine metapLASIA. CASE SyNOPSIS: SYnOPTIC - PRImARy iNVASiVE CARCInOMA OF BREAST LAteraLIty: PROCEDURE: Left  Modified radical mastectomy LQCATION: Upper outer quadrant Lower outer quadrant Size Of TumOR: Maximum dimension invasive component: 5.5 cm MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: TUmOR AGGREgATE SIZE: No Surn of the sizes ot muitlple invasive tumors: 5.5 crn TUMOR TYPE (invasive component):e Ductal adenocarcinoma, NOS NOTTINGHAM SCORE: Nuclear grade: 3 1Cs-O-3 Tubule formalion: 3 caciivmn,mnf#nsHg ducHl nos 85oY3 Mitotic activlty score: 3 Total Nottingham score: 9 Sit: brt, nos c5o.9 3/3/n h Nottingham grade (1, 2, 3): 3 AngiOLYmphAtic inVAsION: Yes DERMAL LymPHATic InVASION: No CALCIFICATION: No TumoR tyPe, in SItu: Cribrifom Solid Comedo DCIS admixed and outside of invasive carcinoma component SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No Distance of invasive tumor to closest margin: 6 mn SURG MARGiNS INVOLVED BY IN SITU COMPONENT: No Distance of in situ disease to closcst margin: 6 mm PAgET'S DISEASE OF nIppLE: No Lymph nODes posItive: 10 LyMPH nODES EXAMINED: 21 UUID:975989FE-8785-42C1-8551-5366187B16A10 METHOD(S) OF LYmPH nODE EXAMINATiOn: TCGA-BH-A0E0-01A-PR Redacted H/E stain SENTiNEl NODE METASTASiS: No OnLy kErAtin pOsitive CelLs Are pResenT: No SIZE OF nODAL METASTASES: LYMPH NODE METASTASIS(-ES) WITH EXTRACAPSULAR EXTENSION: Diameter of largest lymph node metastasis: 28 mm Yes SKIN iNVOLVED (ULCERATION): No No NOn-NeOPLASTIC bREaST TISSUE: AUh, ECD t stage, pathologic: N STAgE. PATHOLOgIC: pT3 m stage, Pathologic: pNX pMX EsTROgen receptoRs: ProgesTerone receptoRS: ncgatlve HSRAINEU negative zeroon
\ No newline at end of file
diff --git a/output/text/f860eff4-5e3e-418d-86e2-72dbfa42081c.txt b/output/text/f860eff4-5e3e-418d-86e2-72dbfa42081c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..42846f129318b36cdd1e01fc76add550e606b882
--- /dev/null
+++ b/output/text/f860eff4-5e3e-418d-86e2-72dbfa42081c.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Icd-o-3 UUID:6C7AE628-18C9-453D-A1C2-5F2F63A295FC Corcinomo, hepatoceJlulcer Nos TCGA-DD-A4NP-01A-PR Redacted 81"70/3 Site: Liver Cxx.D M012/2412 TISSUE DESCRIPTION: A1 B1 C1 C2 C3 C4 C5 C6 C7 C8 C9 C10 C11 C12 C13 C14 C15 C16 C17 C18 C19 C20 C21 C22 C23 Gallbladder (9.0 x 4.0 x 2.4 cm), left portal lymph node (2.0 x 1.3 x 0.8 cm) and left lobe liver (1065 grams, 19.3 x 16.5 x 11.2 cm). DIAGNOSIS: Liver, left lobe, resection: Grade 3 (of 4) hepatocellular carcinoma forming a 15.4 x 11.3 x 10.7 cm mass, arising in histologically unremarkable liver. The margins are negative for tumor (closest margin is free by 0.4cm). No necrosis or angiovascular invasion is identified. Gallbladder, cholecystectomy: Chronic cholecystitis. A single cystic duct lymph node is negative for tumor. Lymph node, left portal, excision: A single left portal lymph node. is negative for tumor. PHOTOGRAPHED IN LAB. PRELIMINARY FROZEN SECTION CONSULTATION: Liver, left lobe, resection: Hepatocellular carcinoma. HoLd OVER for immunostains. Piiz
\ No newline at end of file
diff --git a/output/text/f86c642c-2642-4b0c-b4d6-cf87241f5943.txt b/output/text/f86c642c-2642-4b0c-b4d6-cf87241f5943.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f67a0077ff91ef9abc57f64f42dc90cf30e9d98d
--- /dev/null
+++ b/output/text/f86c642c-2642-4b0c-b4d6-cf87241f5943.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+DIAGNOSIS: 1. Adipose tissue, "over right renal mass"', partial nephrectomy: Adipose tissue, no tumor seen. 2.  Kidney, right, upper pole, cyst wall, partial nephrectomy: Renal parenchyma with fibrosis. 3.Kidney, right, mass/cyst, partial nephrectomy: - Renal cell carcinoma, papillary type I.. - Renal parenchyma with cysts and fibrosis. - Fibroadipose tissue. No tumor seen.. NOTE: CLINICAL INFORMATION: Allocate Order to Protocol: Brief Clinical History:. with bilateral multifocal papillary renal tumors. right robotic.  partial Specimen Taken For. PRocEDuRE: Pre-Operative Diagnosis: right renal mass Post-Operative Diagnosis: same Operative Findings: 3cm renal mass Patient Identification
+
+--- Page 2 ---
+SPECIMENS SUBMITTED: 1. FAT, Over right renal mass 2. CYST, Right upper pole renal wall 3. CYST, Right renal mass. GROSS DESCRIPTION: Received are 3 freshly submitted specimens in containers labeled with patient's. name, medical record number, and further specified as follows: 1. "Fat over right renal mass/cyst" is a yellow soft lobulated adipose tissue fragment, 6.4 x 2.5 x 1.3 cm. It is serially sectioned revealing yellow soft lobulated cut surfaces. Representative sections are submitted in white cassettes #1A-1D. 2. "Right upper pole renal cyst wall" are multiple tan-pink cyst wall lining fragments ranging from 0.2 to 1.5 cm in greatest dimensions and in the aggregate 1.5 x 0.4 x 0.2 cm. Gross photographs are taken. No tissues are procured. The specimen is entirely placed into formalin and submitted to Pathology for. permanent.In  the specimen matches the above description. The cyst wall lining is. entirely submitted in white cassette. #1. "Right rena! mass/cyst" is a disrupted tan-pink cystic structure, 6.5 x 3 x 2.5 cm, filled with friable and hemorrhagic golden yellow-red soft tissues. Gross photographs are taken. Margins are not a concern. per Approximately 50% of tissue is procured for.  The remainder of the specimen is placed into formalin and submitted to Pathology for permanent.. In Surgical Pathology, the specimen. matches the above description. The remainder of the specimen is serially sectioned and entirely submitted in white cassettes. #3A-.... Gross description dictated by.
+
+--- Page 3 ---
+Patient Identification
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diff --git a/output/text/f8926d41-c076-4982-af26-61d4ae291ee5.txt b/output/text/f8926d41-c076-4982-af26-61d4ae291ee5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..90f8c5cd7d18f97768b6552a7ce6de7199b1ce38
--- /dev/null
+++ b/output/text/f8926d41-c076-4982-af26-61d4ae291ee5.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+huct raviinmu i's infiltrntiug, 8.5v0/3 Site: buset, NoS 1122/10 c5o.9 page 1 / 2 Department of Cancer Pathologye copy No. Date: Examination: Histopathological examination. Examination No.. Patient: 1 PESEL: Age: : Gender: F Material: Total organ resection - right breast Unit in charge: Physician in charge: Material collected on: Material received on:. Expected time of examination: up to. Clinical diagnosis: Examination performed on:. Results of immunohistochemical examination:. Estrogen receptors in neoplastic cell nuclei not found. Progesterone receptors found in 75% of neoplastic cell nuclei. HER2 protein stained with HercepTestT" by DAKO. Negative reaction in invasive carcinoma cells ( Score = 1+) Compliance validated by: Examination performed on: Macroscopic description:  Right breast, sized 22 x 15 x 4cm, removed along with axillary tissues sized 9 x 7 x 2 cm and a skin flap of 13 x 7.5 cm. Tumour sized 1.5 x 1.5 x 1.5 cm found on the boundary of inner quadrants, placed 5.0 cm from the upper edge, 0.7 cm from the base and 0.6 cm from the skin.. Microscopic description:  Carcinoma ductale invasivum - NHG2 (3+2+1/2 mitoses/10 HPF - visual area 0.55mm). Numerous  focuses of carcinoma ductale in situ (Dcis) found within tumour (cribrate type, with high nuclear  atypia and comedo necrosis and calcifications, 20% of the tumour). Reactio lymphocytaria. peritumoralis. Glandular tissue showing lesions of the type mastopathia fibrosa et cystica. Axillary lymph nodes: Micrometastases carcinomatosae in lymphonodo (No I/xv). Histopathological diagnosis: Carcinoma ductale invasivum et ductale in situ mammae dextrae. Micrometastases. carcinomatosae in lymphonodo axillae (No t/Xv). (NHG2; pT1c; pN1(mi).) Compliance validated by: UUID:AA6F84C8-D0B4-446F-A8A7-8CE7F9D07ECF TCGA-D8-A141-01A-PR Redacted
+
+--- Page 2 ---
+Examination performed on:. Examination: Histopathological examination page 2 / 2 Examination No.:  Patient PESEL: Gender: F Examination performed on:. Complementary diagnosis:e Following reassessment of receptor status on selected material:. Estrogen receptors found in 75% of neoplastic cell nuc!ei. Progesterone receptors found in 75% of neoplastic cell nuclei. HER2 protein stained with HercepTestM by DAKO. Negative reaction in.  invasive carcinoma cells ( Score = 1+ ) $cTAL. hNvAB1Vt cAnc NOHA OF TNF QictT RRE8T h1c2OmeTA$TA61S nV INE AXILLARY uAmvH NO!E ! Compliance validated by:e
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diff --git a/output/text/f8a2c1bd-0d23-47bb-9fb3-7cdf621ac962.txt b/output/text/f8a2c1bd-0d23-47bb-9fb3-7cdf621ac962.txt
new file mode 100644
index 0000000000000000000000000000000000000000..42a6fbe3c753a807070dadbbf490582b42aca4a7
--- /dev/null
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+
+--- Page 1 ---
+1cd-0 -3 Caranoma, mfiltrating dut. i NCs 85 0o|3 12810 c50.9 Site code: bresst, NO s UUID: 8C7442C0-540C-4023-BBFA-8482935259A7 TSS: TCGA-E2-A15p-01A-PR Redacted SPECIMENS: A. RIGHT BREAST NEEDLE LOCALIZATION B. SENTINEL LYMPH NODE #1 RIGHT AXILLA C. SENTINEL LYMPH NODE #2 RIGHT AXILLA SPECIMEN(S): A. RIGHT BREAST NEEDLE LOCALIZATION B. SENTiNEL LYMPH NODE #1 RIGHT AXILLA C. SENTINEL LYMPH NODE #2 RIGHT AXILLA INTRAOPERATIVE CONSULTATION DIAGNOSIS: A- right breast: 1.5-cm mass at 0.5 cm from posterior margin TPB/TPC- SLN #1, #2 right axilla: Negative for tumor. Diagnoses called by Dr. to Dr. at : .(A) and .(B, C). GROSS DESCRIPTION: A. RIGHT BREAST NEEDLE LOC Received fresh labeled with the patient's identification and "right breast needle loc" is a previously inked, oriented (single stitch-anterior, double-lateral, triple-anterior) 31 g. 3.5 x 3.1 x 3.1 cm needle localized lumpectomy with radiograph. Ink code: Anterior-yellow, posterior-black, medial-green, lateral-red, superior-blue, inferior-orange Specimen is serially sectioned from superior to inferior into 8 slices revealing a 1.5 x 1.3 x 1.1 cm firm tan stellate mass that is closest to the posterior margin at 0.5 cm. Tissue is procured. Representatively submitted: A1: superior margin, perpendicular sections A2: slice 2, posterior medial A3: slice 3, anterior medial A4: slice 4, posterior lateral A5: slice 5, anterior lateral (mass, clip) A6: slice 5, posterior lateral (mass) A7: slice 5, mid anterior A8: slice 5, mid posterior A9: slice 5, medial A10: slice 6, anterior lateral (mass) A11: slice 6, posterior lateral A12: slice 7, anterior lateral A13: slice 7. posterior lateral A14: slice 7, anterior medial A15: slice 7, posterior medial A16: inferior margin, perpendicular sections. B. SENTINEL LYMPH NODE #1 RIGHT AXILLA  Received fresh labeled with the patient's identification and "sentinel lymph node #1" is a 2 x 1 x 0.8 cm lymph node. Sectioned, touch preps are performed; lymph node is submitted entirely in cassette B1. C. SENTINEL LYMPH NODE #2 RIGHT AXILLA  Received fresh labeled with the patient's identification and "sentinel lymph node #2" is a 1 x 0.8 x 0.5 cm lymph node. Sectioned, touch preps are performed; lymph node is submitted entirely in cassette C1. DIAGNOSIS: A. BREAST, RIGHT,WIDE LOCAL EXCISION: - INVASIVE DUCTAL CARCINOMA, SBR GRADE 2, MEASURING 1.1-CM  - INTERMEDIATE NUCLEAR GRADE; DUCTAL CARCINOMA IN SITU, SOLID TYPE - SURGICAL RESECTION MARGINS NEGATIVE FOR TUMOR - FIBROADENOMA (0.2-CM) - BIOPSY SITE CHANGES WITH FIBROSIS AND FOREIGN BODY GIANT CELL REACTION - SEE SYNOPTIC REPORT. B. LYMPH NODE, SENTINEL #1, RIGHT AXILLA, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (0/1). C. LYMPH NODE, SENTINEL #2, RIGHT AXILLA, EXCISION: - ONE LYMPH NODE, NEGATIVE FOR METASTASES (O/1). SYNOPTIC REPORT - BREAST
+
+--- Page 2 ---
+Specimen Type: Excision Needle Localization: Yes Laterality: :Right Invasive Tumor. Absent Multifocality: No WHO CLASSIFICATION .Invasive.ductal.carcinoma, NOS 8500/3 Tumor size: 1.1cm Margins: Negative Distance from closest margin: 0.5cm deep Tubular Score: 3 Nuclear Grade: 2 Mitotic Score: 1 Modified Scarff Bloom Richardson Grade:. 2 Necrosis: Absent Vascular/Lymphatic Invasion: None identified Lobular neoplasia: None Lymph nodes: Sentinel lymph node Lymph node status Negative 0/2 DCIS present Margins uninvolved by DCIS DCIS Quantity: Estimate 10% DCIS Type: Solid DCIS Location:Associated with invasive tumor. Nuclear grade: Intermediate Necrosis: Absent ER/PR/HER2 Results ER: Pending PR: Pending HER2: Negative by IHC Performed on Case:  Pathological staging (pTN): pT 1c N 0  Pathological staging is based on the AJCC Cancer Staging Manual, 7th Edition CLINICAL HISTORY:  Right iateral breast 1.5-cm invasive breast cancer, posterior near fascia, fascia included with specimen. PRE-OPERATIVE DIAGNOSIS:  None given ADDENDUM: SYNOPTIC REPORT - BREAST, ER/PR RESULTS Specimen: Surgical Excision Block Number: A6 ER: Positive Allred Score: 8 = Proportion Score 5 + Intensity Score 3 PR: Positive Allred Score: 4 = Proportion Score 2 + Intensity Score 2. COMMENT: The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring range from O to 8. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score of less than or equal to 2. METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours.  Immunohistochemietn ws oerformed using the mouse anti-human ER (ER 1D5, 1:100) and PR (PGR 136, 1:100) provided by Dakc following the manufacturer s instructions. This assay was not modified. Interpretation of the R/PR immunohistocnemical stain is guided by published results in the medical literature,  information provided by the reagent manufacturer and by internal review of staining performance. ONCOTYPE DX BREAST CANCER ASSAY RESULTS: Recurrence Score: 22 CLINICAL EXPERIENCE: Patients with a recurrence score of: 22 in the clinical validation study had an average. rate of Distant Recurrence at 10 years of 14%
+
+--- Page 3 ---
+ER Score: 11.1Positive Pr Score: 4.4 Negative 10 Negative Her2 Score: Interpretation: ER Negative < 6.5 Positive >= 6.5 Positive >= 5.5 Her2 Negative <10.7 Positive >=11.5 Equivocal = 10.7 - 11.4 See separate ( i report for further information. Test performed at: Microscopic/Diagnostic Dictation: Pathologist. Final Review: Pathologist. Final: Pathologist, Addendum: Pathologist, Addendum Final: Patholoaist. Addendum: Pathologist, Addendum Final: Pathologist,
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diff --git a/output/text/f8c127ad-9e24-436d-8418-48a4d9473468.txt b/output/text/f8c127ad-9e24-436d-8418-48a4d9473468.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f0d355f9ba1150c2adeaa6518fb88c24f23310dd
--- /dev/null
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+
+--- Page 1 ---
+Patient Key: Surgical date: TISSUE DESCRIPTION: Left lobe liver (2195 grams, 26 x 16 x 9 cm), separately submitted tissue from Segment V liver (30 grams, 5 x 4 x 3 cm), needle biopsy from Segment V liver No.1 (2 mm) and No.2 (7 mm), left periportal lymph node (2.1 x 1.3 x 0.8 cm) and gallbladder (8 x 3.5 x 2 cm). A1, B1, C1, C2, C3, C4, C5, C6, C7, D1, D2, E1 DIAGNOSIS: Liver, left lobe, excision: Grade 3 (of 4), hepatocellular carcinoma, usual type, forming a 25 x 16 x 9 cm multinodular mass. The tumor is located in left lobe. The hepatic capsule is free of tumor. The surgical margins are free of tumor, the clearance being 1.2 cm microscopically. Extramural vascular invasion is not identified. The tumor is encapsulated by a 0.5 cm thick fibrous capsule. The approximate percent of necrosis is 10%. The non-neoplastic liver will be assessed on permanent sections and an addendum will be issued. Liver, Segment V, excision: Grade 3 (of 4) hepatocellular carcinoma, forming a mass (3 x 2 x 1.8 cm). The margins are negative for tumor. Liver, Segment V, needle biopsy #1: Hemangioma. Liver, Segment V, needle biopsy #2: Negative for tumor. Lymph node, periportal, excision: A single benign lymph node is identified. Gallbladder, cholecystectomy: No diagnostic abnormalities. ADDENDUM: Permanent sections of the adjacent non-neoplastic liver tissue show no diagnostic abnormalities. An iron stain and PAS-D are negative. Seen with Dr 1cD-0-3 Sercivna hopab cllulev, Nos 817of3 Site, liver C22.0 9/2x/ 11 UUID: C755324B-9882-4319-BDD8-EB8A24107AAC TCGA-DD-A3A4-01A-PR Redacted
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diff --git a/output/text/f8d651f7-b63a-4401-a492-54ae23edf066.txt b/output/text/f8d651f7-b63a-4401-a492-54ae23edf066.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c984c9c13d7869b76e3d9717cb8b1e4ee2d9f95c
--- /dev/null
+++ b/output/text/f8d651f7-b63a-4401-a492-54ae23edf066.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Reporting pathologist(s): CONSULTANT. Sample (TYPE UNSPECIFIED) Collected Received HISTOLOGY ID 0.3 HISTOLOGY brcinone, wrsthelial Nos 81Q013 SPECIMEN H Casinerrdtrsnrtienal celQ HoS A. Bladder tumour.. 8/Q6/s3 B. Base of tumour.. Sut.YLadder Nbs ce7.9 CLINICAL DETAILS JJ 5/21i y New invasive tumour - TURT. UUID:1B5918AB-3C48-405C-BE7F-348E3907060C MACROSCOPY 1A-PR cted A. 5 g of firm tissue chippings. B. 2 pieces of tissue the larger measuring 12 mm. MICROSCOPY A. Grade: 3 poorly differentiated with focal nested pattern Growth pattern: Mixed papillary and solid. Type: Transitional cell carcinoma. Muscularis propria present: Present. Stromal invasion: Invasion of muscularis propria (pT2) Vascular channel invasion: Not identified. Background urothelium: Flat urothelium is present which is not dysplastic SUMMARY Bladder; Transitional cell carcinoma G3 pT2 B.
+
+--- Page 2 ---
+Two fragments of muscularis propria both of which are extensively infiltrated by high grade urothelial carcinoma. SUMMARY Base of tumour; Extensive infiltration by urothelial carcinoma. ary Tumo
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diff --git a/output/text/f8da3a66-2a13-4351-923e-cd3e70e98b95.txt b/output/text/f8da3a66-2a13-4351-923e-cd3e70e98b95.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6d517864c6496994398263892574538219372981
--- /dev/null
+++ b/output/text/f8da3a66-2a13-4351-923e-cd3e70e98b95.txt
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+
+--- Page 1 ---
+Encounter Date: ! Results SURGICAL PATHOLOGY ( Patient Info Patient Name Sex DOB Component Results Surgical Pathology Report: tcD-O:  eeQl 826073 Specimen #:1 Physician: 464.9 J0[713 FINAL DIAGNOSIS 1. LEFT KIDNEY, RADICAL NEPHRECTOMY - RENAL CELL CARCINOMA, PAPILLARY TYPE, FURHMAN NUCLEAR GRADE 2 OF 4 (4.1 CM IN GREATEST DIMENSION). SEE COMMENT. - TUMOR IS CONFINED TO THE KIDNEY. - NO VASCULAR INVASION PRESENT. - ALL SURGICAL MARGINS, INCLUDING VASCULAR, URETERAL AND PERINEPHRIC SOFT TISSUE, ARE NEGATIVE. - ADRENAL GLAND NEGATIVE FOR TUMOR COMMENT This tumor focally has clear cell changes. By immunohistochemistry, these clear cells are negative for cytokeratin 7, similar to conventional clear cell RCC, while the rest of the papillary RCC is positive for this marker. The significance of finding a small component of clear cell RCC in an Otherwise papillary RCC is unknown.. ANALYTE SPECIFIC REAGENT (ASR) DISCLAIMER The use of one or more reagents in the above tests is regulated as an analyte specific reagent (AsR). These tests were developed and their  performance characteristics determined by the They have not been cleared by the US Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. ***Electronic Signature*** SPECIMEN SUBMITTED A: LEFT KIDNEY UUID:0985E4C5-CCC0-49A3-8604-8E0021AEB435 TCGA-IA-A83T-01A-PR Redacted CLINICAL DATA LEFT KIDNEY LESION GROSS DESCRIPTION A. The specimen consists of a left kidney surrounded by an envelope of fibroadipose tissue measuring in total 21.5 x 8.5 x 7.5 cm, and weighing 1,224.25 grams. The kidney measures 11.5 x 5.5 x 4.5 cm. At the Page 1 of 2
+
+--- Page 2 ---
+inferior pole of the specimen, a 5.0 cm in diameter area of exposed capsule is apparent. Underlying this is a 4.1 x 4.0 x 4.0 mass which extends from the inferior pole of the kidney. On sectioning, the mass has a variegated, yellow-red, soft and focally hemorrhagic cut surface. It appears well-circumscribed and does not appear to extend into the perirenal fat or renal sinus, and is not present at the soft tissue margin of the specimen. The closest soft tissue margin is approximately 2 cm from the tumor. Satellite nodules of tumor are not present in the renal tissue. Dissection of the renal veins does not show intravascular presence of neoplasm. The renal parenchyma is pale, with blurred corticomedullary demarcations. There is one large cyst present in the superior pole and several much smaller cysts scattered throughout the renal parenchyma. The cysts are  lined by a smooth wall and are filled with clear fluid. The largest cyst measures 2.0 cm in largest diameter and the smaller cysts range in size from 0.2 to 0.5 cm in diameter. A partially fragmented adrenal gland is visible on the surface of the specimen measuring 5.5 x 1.2 x 1.0 cm and weighing 5.6 grams. The adrenal is without nodules but is somewhat hemorrhagic. It does not appear involved by the mass, and the closest portion of mass is approximately 7 cm distant. A 5.0 cm segment of ureter is present and is essentially unremarkable. Lymph nodes are not present. Representative sections are submitted as follows: A1 frozen section no charge; A2 vascular margins and ureter margin; A3 representative sections of adrenal; A4 & A5 tumor nearest soft tissue margin; A6 tumor nearest renal sinus; A7 tumor nearest renal pelvis; A8 tumor and adjacent kidney; A9 tumor; A10 representative section normal kidney and representative section of kidney with cysts.. Patient ID #: DOB:  Date of Report:. Date of Procedure: Date of Receipt: Submitted by: Location: Lab and Collection SURGICAL PATHOLOGY ( Lon Result History. SURGICAL PATHOLOGY on. Order Result History Report. Result Information Result Date and Tirne Status Provider Status Final result Reviewed Status: This result is currently not released to. Display Full Result Report Display Order Report Page 2 of 2
+
+--- Page 3 ---
+Page 1 of 1 TCGA Pathologic Diagnosis Discrepancy Form 4.05 ). Study Subjectd Person ID:  N/A ID: Study/Site: TCGA Kidney renal papillary cell carcinoma - (Kidney renal papillary cell  Age: N/A! carcinoma) Event: PathDiscrepancy Date of Birth: Interviewer:d Sex: Tumor Identifier Provided on Initial Case Provide the tumor identifier documented on the initial case quality Quality Control Form control form for this case.  Pathologic Diagnosis Provided  renal cell Provide the diagnosis/ histologic subtype(s) documented on the initial pathology. on Initial Pathology Report carcinoma report for this case. If the histology for this case is mixed, provide all listed. subtypes. Histologic features of the sample provided for papillary Provide the histologic features selected on the TCGA Case Quality TCGA, as reflected on the CQCF type Control Form completed for this case. Discrepancy between Pathology Report and Case Quality Control Form Provide the reason for the discrepancy confirmation of clarification of Provide a reason describing why the diagnosis on the between the pathology report and the  KIRP Type II provided in initial pathology report for this case is not consistent with TCGA Case Quality Control Form discrepancy note. the diagnosis selected on the TCGA Case Quality Control Form.  Name of Tss Reviewing Pathologist or Provide the name of the pathologist who reviewed this Biorepository Director case for TCGA.
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diff --git a/output/text/f8de83ae-9cba-4821-afa3-ff25ad551d08.txt b/output/text/f8de83ae-9cba-4821-afa3-ff25ad551d08.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fae150953db6807dde7d67af7dfe033091822fe1
--- /dev/null
+++ b/output/text/f8de83ae-9cba-4821-afa3-ff25ad551d08.txt
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+
+--- Page 1 ---
+UUID:128D4F7D-017D-4S9F-9664-AF509AE4555E TCGA-AR-A2LN-01A-PR Redacted 1cs -0 -3 Carcnoma,infiltraHnq lobuIery N0s 8520/3 Site : bresst Nus. c50.9 8/8/v Final Diagnosis A. Breast, right, mastectomy: Infiltrating lobular carcinoma, Nottingham grade II (of III) [tubules 3/3, nuclei 2/3, mitoses 1/3; Nottingham score 5/9], forming a 2.8 x 2.0 x 1.2 cm mass located in the upper outer quadrant of the breast [AJCC, 7th ed., pT2]. Angiolymphatic invasion is present. The non-neoplastic breast parenchyma shows proliferative fibrocystic changes. Biopsy site changes present. The tumor does not involve the nipple, overlying skin, or underlying chest wall. A seborrheic keratosis is identified in the skin. All surgical resection margins, including deep margin, are negative for tumor (minimum tumor free margin, 2.0 cm, anterior- superior margin).. B. Lymph node, right axillary, sentinel biopsy: One (of 1) axillary sentinel lymph node is positive for metastatic carcinoma, the largest measuring 2.0 cm. Extranodal extension is present. [AJCC, 7th ed., pN1] C. Breast, left, mastectomy: Infiltrating lobular carcinoma, Nottingham grade II (of III) (tubules 3/3, nuclei 2/3, mitoses 1/3; Nottingham score 6/9], and lobular carcinoma in situ, forming a 4.1 x 3.8 x 2.4 cm mass located in the upper subareolar aspect of the breast [AJCC, 7th ed., pT2]. Angiolymphatic invasion is absent. The non-neoplastic breast parenchyma shows proliferative fibrocystic changes. Biopsy site changes present. The tumor involves the nipple. The overlying skin and underlying chest wall are uninvolved. All surgical resection margins, including deep margin, are negative for tumor (minimum tumor free margin, 1.6 cm, anterior-superior margin). D. Lymph node, left axillary, sentinel biopsy: One axillary sentinel lymph node is negative for metastatic carcinoma. Blue dye is identified. Immunohistochemical cytokeratin stain was performed on the paraffin embedded sentinel lymph node tissue and confirms the H&E impression. E. Lymph node, left axillary #2, sentinel biopsy: One axillary sentinel lymph node is negative for metastatic carcinoma. Blue dye is not identified. Immunohistochemical cytokeratin stain was performed on the paraffin embedded sentinel lymph node tissue and confirms the H&E impression. [AJCC, 7th ed., pN0(i-)(sn)] F. Lymph nodes, right axillary, dissection: Multiple (14) axillary lymph nodes are negative for metastatic carcinoma.
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diff --git a/output/text/f8e05fcc-ebf5-48b1-a993-27bbeaded453.txt b/output/text/f8e05fcc-ebf5-48b1-a993-27bbeaded453.txt
new file mode 100644
index 0000000000000000000000000000000000000000..42da96bfc0a602edf40b97b518c2a203feaa262d
--- /dev/null
+++ b/output/text/f8e05fcc-ebf5-48b1-a993-27bbeaded453.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis: 2. Hemicolectomy preparation with a moderately differentiated adenocarcinoma of the. colon ascendens with infiltration of the pericolic fatty tissue. Eight lymph node metastases in total (28 lymph nodes examined). Tumor classification: adenocarcinoma G2 pT3 N2 (8/30') L0 V0 R0. 1 Though the text above says '28'.
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diff --git a/output/text/f8e7b3a8-8881-43c0-9113-f0ca1759b44a.txt b/output/text/f8e7b3a8-8881-43c0-9113-f0ca1759b44a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b1885c1e4793dea152384e5da9c95d2184f4a414
--- /dev/null
+++ b/output/text/f8e7b3a8-8881-43c0-9113-f0ca1759b44a.txt
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+
+--- Page 1 ---
+UUID:7C70BB37-3B12-4980 TCGA-E7-A7PW-01A-PR Redacted TSS Patient ID: Surgical Date: Gross Description: Tumor occupies bladder wall. It is invasive and protruded, ill - margins with 7x5x5cm in size, necrotic, soft and gray surface. Microscopic Description: Tumor is ulcerated and necrotic. Tumor cells are hyperplastic to arrange to form sheets or nest or groups or cords one by one. Tumor cells have moderate and eosinophilic. Nuclei are very enlarged and varriability in shape and size, irregular nuclear membranes, nucleoli and abnormal chromatin patterns. Mitoses are common. Tumor invades in fat tissue and vessel. Diagnosis Details: Infiltrating urothelial carcinoma, high-grade, infiltrating in fat tissue IcD0-3 Comments: Corcnois tsnstinial cell NSS Formatted Path Reports: BLADDER TISSUE CHECKLIST 8/2013 Specimen type: Cystectomy Sie BIadoler NoS. C679 Tumor site: Bladder yU 9/27|)3 Tumor size: 7 x 5 x 5 cm Tumor features: Ulcerated Histologic type: Transitional cell carcinoma. Histologic grade: Poorly differentiated Tumor extent: Perivesical tissue (microscopic). Lymph nodes: Not specified Lymphatic invasion: Not specified Venous invasion: Not specified Margins: Not specified Evidence of neo-adjuvant treatment: Not specified. Additional pathologic findings: Not specified. Comments: None
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diff --git a/output/text/f8ec06c0-56b4-44cf-99f5-8e6a9ccc39f0.txt b/output/text/f8ec06c0-56b4-44cf-99f5-8e6a9ccc39f0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a836c752586575cf06bbe94465d284b8e69c414b
--- /dev/null
+++ b/output/text/f8ec06c0-56b4-44cf-99f5-8e6a9ccc39f0.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Ics-0-3 P'rocedure Date: Procedure Physician:a Attending Physician/Copies To: S.p:BrQxst Nos C5u.9 Patient hIstory: UUID:9F838476-4DF1-44D6-989F-33A1D49042480 * DATE OF LMP: * TCGA-BH-A1FD-01A-PR DATE OF LAST DELIVERY: Redacted PRE-OP DIACNOSIS: LEFT BREAST CA POST-OP DIACNOSIS: SAME OPERATIVE PROCEDURE: LEFT RADICAL MODIFIED MASTECTOMY CLINICAL HISTORY: : MATERIAL SUEMITTED: LEFT (MOD) RADICAL MASTECTOMY, PROCUREMENT BY SURGICAL PROCEDURE and axillary contents LEFT RADICAL MASTECTUMI: ASSOCIATED MICROCALCIFICATIONS (2.O CM) (C.R. SURGICAL MARGINS ARE FRER OF TUMOR IN PLANES OF SECTION - FIBROCYSTIC CHANGRS _WITH FOCAL ATYPICAL DUCTAL EPITHELIAL HYPERPLASIA, MICROSCOPIC RADIAL SCAR AND MICROCALCIFICATIONS - RANDON SECTIONS OF QUADRANTS, NIPPLE AND NINETEEN (19) AXILLARY LYMPH NODES, NEGATIVE FOR TUMOR) NOTE: HER-2/Neu and eR/pR immunoperoxidase assay will be perforned on block A4. SUPPLI EMENTALREPORT (ER/PR'S) My signature below is attestation that I have reviowed all slides and agree with the findings as noted. below. IMMUNOPEROXIDASE IDENTIFICATION OF ESTROGEN AND PROGESTERONE RRCHPTORS IS CARRIED OUT ON SLIDE "A4". DISTINCT INTRANUCLEAR STAINING IS IDENTIFIED FOR ESTROGEN RECEPTOR (7Ot) AND ALSO FOR PROCESTERONE RECSPTOR (9Ot). THEREFORE, BOTH ARE INTERPRETED AS POSITIVE. Pathologist SUDPLSMENTALREPORT (HER-2/NZU) My signature below is attestation that I have raviewed all slides and agree with the findings as noted. below. AS PER THE REQUEST OF I  OF MAGEE-WOMENS HOSPITAL, C-erbB2 (HER-2/NEU) .IMMUNOSTAINING IS CARRIED OUT ON PREVIOUS MAGEE SURGICAL  , BLOCK "A4" (BREAST CANCER) USINC A 1:30O DILUTICN OF DAKO'S POLYCLONAL ANTIBODY A485 (DIRECTED AGAINST THE INTRACELLULAR DOMAIN OF C-OrbB2) WITHOUT ANTIGRN RETRIEVAL. NO DISTINCT COMPLETE MEMBRANE STAINING IS IDENTIFIED. THEREFORE, C-OrbB2 (HER-2/NEU) IS INTERPRETED AS  NEGATIVE. Diegr
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diff --git a/output/text/f8f66c8e-90da-4a2d-a926-df64c4649c5c.txt b/output/text/f8f66c8e-90da-4a2d-a926-df64c4649c5c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c12c853912414260068b5f9ab8e05b802dba57fd
--- /dev/null
+++ b/output/text/f8f66c8e-90da-4a2d-a926-df64c4649c5c.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+1cD-0-3 Carcnoma, lnyittnsting duit, nos 8500/3 Site Code: breaot, NoS c50.9 12/19/10 TSS Pt ID SPECIMENS: A. SLN #1 RIGHT AXILLA UUID:D05A4266-6719-4916-B7D0-A23275A88266 B. SLN #2 RIGHT AXILLA TCGA-E2-A106-01A-PR Redacted C. SLN #3 RIGHT AXILLA D. RIGHT BREAST E. RIGHT AXILLARY CONTENTS LEVELS 1-2 F. ADDITIONAL RIGHT BREAST TISSUE G. ADDITIONAL INFERIOR MARGIN SPECIMEN(S): A. SLN #1 RIGHT AXILLA B. SLN #2 RIGHT AXILLA C. SLN #3 RIGHT AXILLA D. RIGHT BREAST E. RIGHT AXILLARY CONTENTS LEVELS 1-2 F. ADDITIONAL RIGHT BREAST TISSUE G. ADDITIONAL INFERIOR MARGIN INTRAOPERATIVE CONSULTATION DIAGNOSIS: TPA-sentinel lymph node #1 right axilla: Positive for carcinoma {Dr.. consulted} called by Dr. to Dr. at  GROSS DESCRIPTION: A. SLN #1 RIGHT AXILLA Received fresh is one lymph node measuring 0.8 x 0.7 x 0.2 cm. One touch prep is performed. Lymph node is submitted entirely in cassettes A1-A3.. B. SLN#2 RIGHT AXILLA Received fresh is a lymph node measuring 1 x 0.6 x 0.4 cm. Submitted in cassette B1. C. SLN#3 RIGHT AXILLA Received fresh is a piece of yellow-tan soft tissue measuring 3.2 x 1.5 x 0.3 cm. One possible lymph. node.is_identified measuring 0.1-cm. Lymph node is submitted in cassette C1. D.RIGHTBREAST Received fresh is an oriented 205g, 15 x 13 x 4.5 cm mastectomy with 4.5 x 3 cm tan skin ellipse, 1.5 cm everted nipple. Superior anterior margin is inked yellow, inferior anterior margin blue, the deep margin black. The specimen is serially sectioned from lateral to medial revealing the following: 1) A granular tan irregular mass'{lesion #1} measuring 4.5 x 2.7 x 1.5 cm in the mid to upper inner quadrant. It is 1 cm from the deep margin and abuts the anterior/superior margin. 2) A 1 x 0.8 x 0.7 cm granular pink-tan area {lesion.#2} that is 2 cm inferior to lesion #1. 3) 0.5 cm possible biopsy site in upper outer quadrant that is 1.5 cm lateral to lesion #1 and is 2.7 cm from the deep margin.. Representatively submitted as follows:. D1-D2: lesion #1 including anterior/superior margin D3-D4: complete cross-section extending from anterior/superior to deep, lesion #1 D5: lesion #1 including deep margin D6: lesion #2 and tissue connecting to lesion #1 D7: lesion #2 and skin D8: tissue extending from lesion #1 to possible biopsy site. D9-D11: possible biopsy site D12: granular tissue from superior anterior margin D13: upper inner quadrant D14: lower inner quadrant D15: lower outer quadrant D16: upper outer quadrant D17-D18: nipple D19-D20: soft tissue from axillary tail. E. RIGHT AXILLARY CONTENTS LEVELS 1-2
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+Received in formalin are multiple tan pink soft tissue fragments aggregating to 5 x 3 x 2cm. Dissection reveals 17 possible lymph nodes ranging from 0.2 x 0.2 x 0.2cm to 2.0 x 2.0 x 1.5cm. Entirely submitted: E1: 5 lymph nodes E2: 4 lymph nodes E3: 4 lymph nodes E4: 2 lymph nodes E5: 1 lymph node serially sectioned. E6: 1 lymph node serially sectioned E7-E8: additional axillary tissue E9-E13: remainder of tissue F. ADDITIONAL RIGHT BREAST TISSUE Received in formalin is an 8g unoriented aggregate of tan pink fibrofatty tissue 5.0 x 4.0 x 2.0cm. The specimen is inked Black and serially sectioned to reveal grossly unremarkable breast parenchyma. Toto F1-F9. G. ADDITIONAL INFERIOR MARGIN Stitch at new true margin. Received in formalin is a 28g oriented tan pink fragment of fibrofatty tissue 11.0 x 5.0 x 1.5cm. The new true margin is inked Black and the specimen is serially sectioned to reveal grossly unremarkable breast parenchyma. Toto G1-G27. RESULTS: SUMMARY OF IMMUNOHISTOCHEMISTRY/SPECIAL STAINS Material: Block A1 Population: Tumor Cells Stain/Marker:Result:  Comment:. CYTOKERATIN AE1/3 Positive Material: Block A2 Population: Tumor Cells Stain/Marker:Result:  Comment: CYTOKERATIN AE1/3 Negative Material: Block A3 Population: Tumor Cells Stain/Marker:Result:  Comment:. CYTOKERATIN AE1/3 Positive The interpretation of the above immunohistochemistry stain or stains is guided by published results in. the medical literature, provided package information from the manufacturer and by internal review of staining performance and assay validation within the Immunohistochemistry Laboratory of The use of one or more reagents in the above tests is regulated as an analyte specific reagent (ASR). These tests were developed and their performance characteristic determined by the Department of Pathology Laboratory at. They have not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary.
+
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+ Special stains and/or immunohistochemical stains were performed with appropriately stained positive and negative controls. DIAGNOSIS: A. SENTINEL LYMPH NODE #1, RIGHT AXILLA, BIOPSY: - MICROMETASTATIC CARCINOMA TO ONE LYMPH NODE, WITH NO EXTRANODAL EXTENSION (1/1) (SEE NOTE). NOTE: There are two foci of micrometastasis, each measuring less than 1 mm in size. A cytokeratin AE1/3 stain was performed that highlights the micrometastases and also shows a few scattered cytokeratin positive cells in the parenchyma. B. SENTINEL LYMPH NODE #2, RIGHT AXILLA, BIOPSY: - ONE LYMPH NODE, NO TUMOR SEEN (0/1). C. SENTINEL LYMPH NODE #3, RIGHT AXILLA, BIOPSY: - ONE LYMPH NODE, NO TUMOR SEEN (0/1). D. BREAST, RIGHD MASTECTOMY: - MULTICENTRIC INVASIVE DUCTAL CARCINOMA, MODERATELY DIFFERENTiATED (SBR GRADE 2) (SEE NOTE) - TUMOR MEASURES 1.2 CM IN GREATEST DIMENSION - INVASIVE CARCINOMA IS WITHIN 1 MM OF THE ANTERIOR MARGIN IN THE UPPER INNER QUADRANT. - EXTENSIVE DUCTAL CARCINOMA IN SITU (DCIS), CRIBRIFORM, SOLID AND MICROPAPILLARY TYPES, NUCLEAR GRADES 2 AND 3, WITH NECROSIS AND MICROCALCIFICATIONS, INVOLVING LOBULES - DCIS IS PRESENT AT THE ANTERIOR MARGIN IN THE UPPER INNER QUADRANT. - DCIS INVOLVES LACTIFEROUS DUCTS. - SKIN AND NIPPLE, NO TUMOR SEEN. NOTE: In the upper outer quadrant, a biopsy site is noted with adjacent DCIS. Near the biopsy site, a 2 mm focus of invasive ductal carcinoma is seen. In the upper inner quadrant, there is invasive ductal. carcinoma with DCIS, with the largest focus of invasion measuring 1.2 cm and with at least one other. focus of invasion that measures 0.1 cm. The DCIS in the upper inner quadrant is mass forming and. spans at least 4 cm in greatest dimension. E. AXILLARY CONTENTS, RIGHT, LEVELS 1-2, DISSECTION: - 13 LYMPH NODES, NO TUMOR SEEN (0/13). F. BREAST, RIGHT, ADDITIONAL TISSUE, EXCISION: - DUCTAL CARCINOMA IN SITU, PRESENT AT INKED ASPECT (SEE NOTE). NOTE: There is a 3 millimeter focus of DCIS. The tissue was not oriented but was inked entirely black and DCIS is present at the inked aspect. G. BREAST, RIGHT, ADDITIONAL INFERIOR MARGIN, EXCISION: - FOCAL COLUMNAR CELL CHANGE WITH CYTOLOGIC ATYPIA (FLAT EPITHELIAL ATYPIA). - NO EVIDENCE OF CARCINOMA. SYNOPTIC REPORT - BREAST Specimen Type: Mastectomy Needle Localization:  No Laterality:(Right) Invasive Tumor: Present Multifocality: Yes. WHO CLASSIFICATION Invasive ductal carcinoma, NOS 8500/3 Tumor size:*1.2cm
+
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+Tumor Site: Upper outer quadrant Upper inner quadrant. Margins:  Negative Distance from closest margin: Less than 0.1cm anterior Tubular Score: 3 Nuclear Grade: 2 Mitotic Score: 1 Modified Scarff Bloom Richardson Grade: 2 Necrosis: Absent Vascular/Lymphatic Invasion: Present Extent: Focal Lobular neoplasia:. None Lymph nodes: Sentinel lymph node and axillary dissection Lymph node status: Positive 1 / 16 Micrometastases: Yes Non-neoplastic areas: columnar cell change with flat epithelial atypia DCIS present Margins involved by DCIS: anterior DCIS Quantity: Estimate 75% DCIS Type: Solid Cribriform Micropapillary DCIS Location: Both associated and separate from invasive tumor mass Nuclear grade: High Necrosis: Present Location of CA++: DCIS ER/PR/HER2 Results ER: Positive PR: Positive HER2: by FISH Pathological staging (pTN): pT 1c N 1mi SYNOPTIC REPORT - BREAST HER-2 RESULTS Specimen: Surgical Excision Block Number: D2 Interpretation: EQUIVOCAL Intensity: 2+ % Tumor Staining: 10% Fish Ordered: Yes , on Date METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Her2 analysis was performed using the FDA approved Dako HercepTest (TM) test kit ( i using rabbit anti-human HER2. This assay was not modified. External kit-slides provided by the manufacturer (cell lines with high, low and negative HER2 protein expression) and in- house known HER2 amplified control tissue were evaluated along with the test tissue. Adequate, well preserved, clear-cut invasive carcinoma was identified for HER2 evaluation. Interpretation of the HER2 mmunohistochemical stain is guided by published results in the medical literature, information provided by the reagent manufacturer and by internal review of staining performance. This assay has been validated according to the 2007 joint recommendations and guidelines from ASCO and CAP and from the NCCN HER2 testing in Breast Cancer Task Force. The Pathology Department takes full responsibility for this test's performance. CLINICAL HISTORY:S -year-old female with abnormal screening mammogram of right breast at right upper outer quadrant. Need!e biopsy showed invasive ductal carcinoma. Patient then had MRI which showed enhancement of
+
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+upper outer quadrant and upper inner quadrant; anteriorly there was enhancement 2 cm from clip and close to nipple. PET, CT and bone scan show no evidence of metastatic disease. Invasive ductal carcinoma SBR grade 2, ER positive, PR positive, Her2/neu negative. Tumor size 0.4 cm, also with high grade DCIS solid and cribriform with necrosis and extension to lobules. PRE-OPERATIVE DIAGNOSIS: Right Breast Cancer ADDENDUM: PathVysion HER-2 DNA Probe Kit Case No Analytical Interpretation of Results:. HER-2 NOT AMPLIFIED Clinical Interpretation of results Amplification of the HER-2 gene was evaluated with interphase fluorescence in-situ hybridization (FiSH) on formalin-fixed paraffin embedded tissue sections using a chromosome. 17 centromeric probe and a HER-2 probe that spans the entire HER-2 gene in the Pathology Core Facility by Dr.. A majority of tumors cells displayed 2 chromosome 17 signals and 2 HER-2 signals, with a HER-2/CEP 17 Ratio </=2.0, consistent with no amplification of the HER2/neu gene.. Block used A1 Source of case: RPCI Tissue fixation formalin-fixed tissue Outside Case No:NA Tissue source breast Results interpreted: yes HER2/CEP17 ratio: 1.05 This ratio is derived by dividing the total number of LSI HER-2/neu signals by the total number of CEP17 signals in at least 20 interphase nuclei with nonoverlapping nuclei in the neoplastic mammary epithelial cells. Cells with no signals or with signals of only one color are disregarded.. Method of ratio enumeration: manual count. Limitations The Vysis PathVysion Kit is not intended for use to screen for or diagnose breast cancer. It is intended to be used as an adjunct to other prognostic factors currently used to predict disease-free. and overall survival in stage Il, node-positive breast cancer patients. In making decisions regarding. adjuvant CAF treatment, all other available clinical information should also be taken into. consideration, such as tumor size, number of involved lymph nodes, and steroid receptor status. No treatment decision for stage II, node-positive breast cancer patients should be based on HER- 2/neu gene amplification status alone. Overview of this test FDA APPROVED REAGENT PathVysion HER-2 DNA Probe Kit is FDA approved for selection of natients for whom Herceptin therapy is being considered. These tests were performed in the under the direction of Dr. The results of these studies should always be interpreted in the context of the clinical, morphological, and immunophenotypic diagnosis.. ONCOTYPE DX BREAST CANCER ASSAY RESULTS: Recurrence Score: 16 CLINICAL EXPERIENCE: Patients with a recurrence score of: 16 in the clinical validation study had an average rate of Distant Recurrence at 10 years of 10% ER Score: 10.1Positive PR Score: 7.7 Positive Her2 Score: 9.8 Negative Interpretation: ER Negative < 6.5 Positive >= 6.5 PR Negative < 5.5 Positive >= 5.5 Her2 Negative <10.7 Positive >=11.5Equivocal = 10.7 - 11.4 See separate report for further information. Test performed at: Inc.
+
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+Gross Dictation.., Pathologist, Microscopic/Diagnostic Dictation:, M.D., Pathologist, ' Final Review: M.D., Pathologist,. Final Review:, M.D., Pathologist, Final:, M.D., Pathologist, Addendum.., Pathologist, Addendum Final: Pathologist,. Addendum.., Pathologist, Addendum Final:., Pathologist,
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diff --git a/output/text/f942707d-63ec-40c6-a5ef-53d0fd4635ab.txt b/output/text/f942707d-63ec-40c6-a5ef-53d0fd4635ab.txt
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index 0000000000000000000000000000000000000000..7df6f10bf71fa61d2044a1e6933711323cabe8a0
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+LcD-O-3 eromo, yayellary reral Cell 8Qw0|3 Operative Procedure: Left nephrectomy, median sternotomy Sit: Ctidnuy,Nos C64.9 Pre-Operative Diagnosis: As below 9O 1(os) n3 Post-Operative Diagnosis: As below Specimen Received: Left radical nephrectomy and caval thrombus with hilar and retroperitoneal lymph nodes Final Pathologic Diagnosis: Kidney and adrenal gland, left, radical nephrectomy with caval-atrial thrombus removal; hilar and retroperitoneal lymph nodes, regional resection: Tumor histologic type: Papillary renal cell carcinoma, type I. Sarcomatoid features (%): None Tumor size: 11 cm Other dimensions: 6.5 x 4.5 cm Macroscopic extent of tumor:  Invades renal vein with protruding thrombus (clinically caval-atrial). Focality: Unifocal Number of tumors: Not applicable UUID:D376CBAF-A4AA-4C3C-95AF-28F57356BE11 TCGA-GL-A59R-01A-PR 3 of 4 Redacted Fuhrman grade: Microscopic extent of tumor: Perinephric fat invasion: No Renal sinus invasion: Yes Other: Not applicable Renal vein involvement: Yes with tumor adherent to renal vein wall Adrenal gland present: Yes Involved by tumor: No Cancer at resection margin: Yes (If yes) Location(s): Renal vein (see Note) Pathologic findings in nonneoplastic kidney: Benign cortical cysts Hilar lymph nodes present:  yes Number involved/number present: 0/9 Pathologic stage (2010) pT3c pN0 pM-Not applicable The examination of this case material and the preparation of this report were performed by the staff pathologist.
+
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+Note: A section taken from the renal vein at the resection margin shows the tumor thrombus. The thrombus is adherent to the vein wall at this point and this is considered to represent a positive surgical margin. Gross Description: Received is a single formalin filled container labeled with the patient's name and additionally labeled "left radical nephrectomy and caval thrombus with hilar and retroperitoneal lymph nodes." Specimen components and dimensions: The specimen consists of the product of a. left radical nephrectomy with left kidney, left renal pelvis and a part of the Ieft renal vein. There is an abundant amount of perinephric fat attached that contains the left adrenal gland. The specimen has been previously opened to reveal the tumor. The specimen aggregately measures 25 x 19 x 7 cm in greatest dimension. The renal parenchyma measures 11.5 x 9 x 5.4 cm in greatest dimension. The ureter is attached and measures 12.2 cm in length and 0.3 cm in diameter. The adrenal gland measures 8 x 4.5 x 1.4 cm in greatest dimension and weighs 20.3 g. Size, appearance, and location of tumor: The tumor is pink-tan to brown in color with hemorrhagic areas. It has a variegated surface and almost entirely. replaces the renal parenchyma. It measures 11 x 6.5 x 4.5 cm in greatest dimension. The tumor involves the renal sinus, the renal sinus fat and the renal pelvis grossly and extends into the renal vein with a protruding thrombus measuring 6.5 cm in length beyond the renal vein margin. Renal capsule/renal sinus: The renal sinus is completely replaced by the tumor mass. The tumor approaches the renal capsule, however no invasion is grossly identified. The renal capsule strips with ease. Renal vein: The renal vein is occluded by the tumor mass, thrombus. The tumor thrombus extends beyond the renal vein margin by 7 cm. Lymph nodes (size, number, & location): The perihilar fat has been dissected for lymph nodes with at least eight lymph nodes identified grossly. The rest of the fat is placed in a clearing agent. Other findings: There is a cortical cyst near the lower pole measuring 4.5 x 2.2 x 2.4 cm in greatest dimension. The normal renal parenchyma has a cortical thickness of 0.5 cm.. Blocks submitted:. 1 caval thrombus; 2 renal vein with the attached thrombus; 3 distal ureter margin and arterial margin; 4 tumor to renal sinus; 5-6 tumor to renal capsule; 7-9 representative sections of tumor to capsule; 10 representative section of cortical cyst 11 representative section adrenal gland; 12 three whole lymph nodes; 13 two whole lymph nodes; 14 one bisected lymph node; 15-16 one serially sectioned lymph node; 17 one bisected lymph node; lw 10(sll
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diff --git a/output/text/f9542d4d-0401-4e0e-8ef7-fac61a79cb9f.txt b/output/text/f9542d4d-0401-4e0e-8ef7-fac61a79cb9f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..54bf87436cc485578ce4f4edeb0d795056e8674f
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+p.7/33 FINAL DIAGNOSIS: A. INFILTRaTing Ductal CARcinQma (18. 1c, 1e, 1f. and 1g) with metaPLAstic CArcinomA Component (8quamous metaplAsia) anD fOcal apOcrine feature8 (see s,omment). B. the tumor size iS 2.5 x 1.3 x 1.8 Cm. C.  nOTTingham SCOre is 9/9 (TuBULe8 3, NUcLei 3, MITOsES 3). D. LyMPhOVASCULAR PERmEATION IS NOt APPRECiATeD. DUCTAL CARCINOMA IN SITU. SOLID AND CRIBRIFORM TYPES, NUCLEAR GRADE 3. REPRESENTING ABOUt LE8S tHAN 1% OF TUmOR VOLUME. DuctaL CARcInOmA IN SItU iS PRESENT ADmIXeD AND OutsIDe Of tme invasive Tumor. MARGInS OF RESECTION ARE-FREE Of TUmOR. G. CHANGES CONSISTENT WITH PREVIOUS CORE BIOPSY, SEE PRIOR (AEMQA T) H. FI8ROCYSTIC.ChAnGes.WITh DUCt ecTASIA, COLumnAR CELl CHAnges And SCLeROSing ADeNOSIS WITH ASSOCIATED MICROCALCIFICATIONS. I. SmALl inTraDuctal PaPIlLoma. CALCIFIED nODULe WITH PERiDUCTAL iNFLAMMATION AND FiBROADENOmATOID nODULE (1J) K.  immunOhIstochemical StaIning fOr estrogen receptOr, PRogeSterone ReceptoR AnD her- 2/NEU A9 PReViOUSLY PERFOrMED ON REcEPtOR - POsITivE, PrOgeSterONe kcCepTOR - NEgaTIve. And hEr-2/neU - NEgAtIve (ScORE AND WErE REPORTeD AS fOLLOWS: EsTrOGeN 0). Part 2: Lymph node, Left sentinel #1, BiOpsy -- One lymph node, free of tumor (0/1). 1cs-0-3 Part 3: Lymph node. Left sentinel #2, BiOpsy - C ucinomn, n fiItntrg oluchl ard mtnp/us#c,#s 8575/3 One lymph node, free of tumor (o/1).. Sih: bruast, Nos c5U.9 33 PARt 4: Lymph nODE, LEfT SEnTinEL #3. BIOpSy -- One lymph node, free of tumor (0/1). Part 5: Breast, Left, New posterior margin, Excision - A No tumor is seen. B.  FIBrOaDenOmAtOid NODuLEs wITH AS8OciATed miCROcALCIFICATIOns. C.  FIsROCySTiC ChAnges WITh DUcTal epITHeLiAl hyperpLASIa AnD COLumnAr CELL ChAngES WItH ASSOcIATeD MICROcalcIFicaTIONS. FOCAL ChrONIc inFLammatiOn wItH GIant CELl GranuLOmatOUs REActIOn.  MediaL. CaLCificATiOn nF Ri AAA CAse syNopsis:  SyNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST LATeraLity: I eft PROCEDURE: LOCATION: Segmental Not specifled Size of tumor:  Maxunum dimansion invasive component: 2.5 cm MULTICENTRICITY/MULTIFOCALITY OF iNVASIVE FOCI: TUMOR TYPE (Invasive component): No Ductal adenocarcinoma, NOs. Mctaplastic carcinoma notTingham score: Nudlasr grade: 3 Tubula formation: 3 Mitotic activity score: 3  UUID:C96287D0-A60B-4BAA-ABA0-8AD4F48662DB Total Nottingham score: 9 TCGA-BH-A0DL-01A-PR Redacted Nottingham grade (1. 2, 3): 3 AngIOLYMPHATIC INVASION: DERmAl LymphaTIc iNvasion: No Not applicable CALCIFICATION: Yes. bomyn zones Tumor type, in situ: Cribritnrm Solid DCIS admixed and outsidc ol invasive carcinoma componcn!. Percent of tumor occupled by in situ cormponent: 1 % SURGICAL MArGInS InVOLVED BY inVASIVE COmPOneNT: SURG MARGINS INVOLVED BY IN SITU COMPONENT:E No No Lymph nooes posiTive: Criteria 0 Lymph nodes examineD: 3 methOd(S) Of Lymph nOde ExAminaTiON: H/E gtain SENTINEL NODE METASTASIS:E No  NOn-NEOpLAStIC BREAST TISsUE: Finroadcnoma, FCD t stage, pathologic: p|2 N stage, pathologic: nNO m stage. Pathologic: pMX Estrogen receptors: positive Progesterone receptors: negative HER2/NEU: zero or 1+
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diff --git a/output/text/f97de8a2-7f01-49b9-9820-e7e973751a6d.txt b/output/text/f97de8a2-7f01-49b9-9820-e7e973751a6d.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9c99affba5016a99b154bc52bc491340ad406824
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+1c0-0-3 Sits: breast Nos. c5e.9 1f2sfr lw FOR OIFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: FMP/SSN: DOB/Age/Sex: ! Race: wEITE Taken: Location: Received: Physician(s) : Reported: SPECIMEN: A: SENTINAL LYMPH NODE #1 B: SENTINAL LYMPH NODE #2 C: LEFT BREAST TISSUE FINAL DIAGNOSIS: A. LYMPH NODE, SENTINEL #1, EXCISIONAL BIOPSY:  TWO (2) LYMPH NODES NEGATIVE FOR MALIGNANCY BY ROUTINE AND IMMUNOHISTOCHEMICAL STAINS. B. LYMPH NODE, SENTINEL #2, EXCISIONAL BIOPSY: - ONE (1) LYMPH NODE NEGATIVE FOR MALIGNANCY BY ROUTINE AND IMMUNOHISTOCHEMICAL STAINS. C. BREAST, LEFT, BIOPSY: -MULTIFOCAL INFILTRATING DUCTAL CARCINOMA (TWO FOCI, 1.5 CM AND O.6 CM IN GREATEST DIMENSION), INTERMEDIATE GRADE BY COMBINED HISTOLOGIC CRITERIA. -SURGICAL MARGINS: LARGER TUMOR 2.0 MM FROM SUPERIOR MARGIN. SMALLER TUMOR 1.5 MM FROM SUPERIOR MARGIN. -NO EVIDENCE OF LYMPHVASCULAR INVASION. -IN-SITU COMPONENT:   DUCTAL CARCINOMA IN-SITU (INTERMEDIATE GRADE, CRIBRIFORM PATTERN, COMPRISING 1O% OF THE TUMOR).S ** Report Electronically Signed Out ** CLINICAL DIAGNOSIS AND HISTORY: -year-old female with infiltrating ductal carcinoma of the left breast diagnosed on core biopsy. UUID:61BC91AE-CD06-432D-BCBA-6FAE2209C610 TCGA-A2-A0EQ-01A-PR Redacted Page 1 Continued on Next Page FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
+
+--- Page 2 ---
+FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974 SURGICAL PATHOLOGY REPORT Patient: Specimen #: GROSS DESCRIPTION: A. SENTINEL LYMPH NODE #1  received in formalin, labeled with the patient's name, designated "SENTINEL LYMPH NODE NUMBER ONE" consists of a tan, fibrofatty tissue fragment measuring 2.0 x 1.3 x 0.4 cm in size. Sectioning reveals two ovoid, tan nodules suggestive of lymphoid tissue. The largest one is 0.5 cm in size, the smaller is 0.4 cm in size. The specimen is bisected and entirely submitted in cassette A. B. SENTINEL LYMPH NODE #2 received in formalin, labeled with the patient's name, designated "SENTINEL LYMPH NODE NUMBER TWO" is a roughly ovoid, tan, firm tissue fragment measuring 0.6 x 0.5 x 0.4 cm in size. Sectioning reveals a well-delineated, homogeneous tan nodule suggestive of a lymch node. The specimen is trisected and entirely submitted in B1. C. LEFT BReasT TissuE received in formalin, labeled with the patient's name, designated "LEFT BReAsT TIssue" is a fibrofatty tissue fragment originally received fresh measuring 6.8 x 6.5 x 2.1 cm, impaled with a needle localization wire. A radiograph accompanies the specimen. The specimen is oriented with sutures (one stitch=medial, two stitches=superior, wire-anterior). The specimen is inked as follows: Red-medial and lateral, blue-superior, green-inferior, yellow-anterior, and black-posterior. Sectioning reveals a 1.5 cm tumor with well-defined margins and abutting the superior margin. The tumor has a tan, gritty cut surface. Approximately 1.0 cm lateral to the tumor is a second firm, well-defined nodule. The remaining tissue is mostly fat with patches of. white, fibrous tissue. Two sections of the tumor and one section of grossly normal fibrous tissue (lateral margin, approximately 3.0 cm from tumor) are submitted for the cbcp protocol (matching paraffin sections-Al-A3 respectively). The remaining specimen is sectioned and submitted from lateral to medial in additional cassettes labeled C4-c15. Slide key: C4: Lateral most margin. C5-c6: Paired sections. c7-c8: Previously described smaller mass. c9-c10: Paired sections. C11: Same area as c2. C12: Same area as C1. C13-c14: Sections of largest tumor mass. c15: Section demonstrating medial most margin. 15cFss Page 2 End of Report FOR OFFICIAL USE ONLY - PERSONAL DATA - PRIVACY ACT OF 1974
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index 0000000000000000000000000000000000000000..bfbf0027cbf4aa8d3cfb36ea3cd2e8897d9bcf28
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+
+--- Page 1 ---
+Patient Results UUID:C522C0BD-7968-48C0-8E96-6143740993E7 Requested By: TCGA-FF-A7CR-01A-PR Redacted Histopathology Report. Biopsy No: Corrected Received Date/Time Final Reporting Information Date/Time : Final Updated Histopathologist : Laboratory : Consultant-In-Charge Final Submitting Physician Final  Histopathology Report Final Updated ADDENDUM ADDENDUM TO HISTOPATHOLOGY REPORT ICD O-3 Immunohistochemistry shows a population of cD20+ Lymghmoclifguse large B-cells, dispersed and coalescing amidst a background of smali B-lymphocytes, with both 9&0/3 B Cl components highlighted by B-cell-specific activator protein shown on double labelling to aberrantly coexpress CD5::(which highlights an Sute Cruicol lynysmsde occasionai large cell in mitosis on the single stain) in excess of the amount accounted for by C770 background, small-to-medium sized, cn2/3/7+ T-lymphocytes, albeit plentiful, consistent with a 8/26/13 brisk, reactive accompaniment, an impression further supported by an excess of the cD8 over the CD4 subset,' the latter upon subtraction double immunolabelling for cDl63(+) histiocytes. The overall cell proliferation fraction is 20-30% on Ki-67 immunolabelling.. Immunostaining for cyclin. D1 is negative within the lymphoid population, highlighting only physiological expression in scattered histiocytic and activated endothelial nuclei, ruling out mantle cell lymphoma and its variants. cDl38-positivity is restricted to mature. mature plasma cells with a kappa:lambda ratio ranging between 3:2 to 2:l on mRNA in situ hybridisation (Ish), also consistent with a reactive accompaniment, and negating plasmablastic lymphoma in conjunction with negativity for both CD30 (which is seen only as physiological. coexpression in a minor subset of plasma cells) as well as for EBV-Encoded RNA (EBER) on ISH. CD21-immunoreactive follicular dendritic meshworks. are not identified, and cdlo positivity appears to reflect only physiological expression in scattered. stromal cells and is negative in the lymphoid population, while cb20(+) large B-cells demonstrably coexpress Mum.1 on double immunolabeliing, consistent with an "activated" state congruous with that of diffuse large B-cell. lymphoma (DLBCL). DIAGNOSIS LEFT NECK LYMPH NODE; INCISIONAL BIOPSIES: DIEFUSE AGGRESSIVE LYMPHOMA. PENDING WORKUP. Patholoqist Printed from: End of Report Page: I of
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diff --git a/output/text/fa28cf32-dc61-4f0e-839d-0e4d04b98fd6.txt b/output/text/fa28cf32-dc61-4f0e-839d-0e4d04b98fd6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4100ba78a71b006b7d3a7c5fed9a27257477bd69
--- /dev/null
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+
+--- Page 1 ---
+1cs-0-3 mfiltrstrng out NoS 8500/3 Csrtomnt, AsH: Situ Crdi busst, urowmin gsdrst CS0.2 y17/1 Patient: Cqef: breaot Nos c50.9 l Surgical Pathology: Finat Surg Path CLINICAL HISTORY: History.of recurrent left breast carcinoma with probable involvement of right breast.  S/p left MRm and indurated firm area UIQ/of right breast on physical exam. Rule out right breast recurrent carcinoma. GROSS EXAMINATION: A. "Right breast biopsy", received fresh. Two pieces of tissue measuring 3.6 x 2.1 x 1.5 cm and 2.2 x 1.7 x 0.7 cm.  The surgeon has stated the margins on the piece of tissue are not important. Portions of the specimen have been previously submitted for retinoic acid receptors and ER/pR evaulation. Both fragments are composed of firm pink-tan tissue embedded within yellow fibroadipose tissue.  Remaining tissue is sectioned and submitted in Blocks Al-A4. DIAGNOSIS: A. "RIGHT BREAST BIOPSY": INFILTRATING DUCTAL CARCINOMA, NSABP AND NUCLEAR GRADE 3, HISTOLOGIC GRADE 3. SURGICAL MARGINS NOT EVALUATED. Verified by:: (Eectronic Signature) Date Signed:. UUID: E958CD3C-EE14-4CE1-B55C-7830E320F6AE TCGA-B6-A0I8-01A-PR Redacted eBrowser Result fo. 1 of !
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diff --git a/output/text/fa67f42f-6ad7-4cf9-8ef0-345b0ab582be.txt b/output/text/fa67f42f-6ad7-4cf9-8ef0-345b0ab582be.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e8f999fcdf3cd084b639fa255b071b9168d4131a
--- /dev/null
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+
+--- Page 1 ---
+IcDI-3 Adentaruirmt, durt mifi1mtiny 850of Sih Cu: brst nos c5o.9 Patient. Surgical Pathology: Final: Surg Path UUID: CA834E5F-30DC-46CF-AF33-AD11226FC09E TCGA-B6-A0I2-01A-PR Redacted CLINICAL HISTORY: Bilateral carcinoma of the breast.. GROSS EXAMINATION: A. "Medial margin right breast biopsy", fresh. The specimen consists of 3.7 x 2.2 x 0.6 cm disc of firm white, unremarkable breast tissue; four sutures denote the true margin, which is inked black. Serial radial sections are submitted as follows: BLOCK SUMMARY: A1  frozen section remnant Af1 A2 frozen section remnant AF2. A3 frozen section remnant AF3. A4 additional tissue. B. "Right breast biopsy sample". Contains an irregular 10 x 0.5 x 1.7 cm disc tan-brown coarsely papillary tissue. Portions are submitted for ER/pR and for tissue bank and for frozen section. Frozen section remnant submitted in Block B1. "Left breast tumor, wide reexcision, long suture lateral, short suture. superior", fresh. The specimen consists of a 4.5 x 4.3 x 2.2 cm wide reexcision of the breast. The long suture denotes the lateral aspect of the specimen and a short suture the superior. The superior pole of the tissue is inked black, and the inferior blue. On cut section, there is a 1.3 x 1.3 x 1 cm round, white, firm, gritty, sharply-circumscribed tumor in the superior portion of the resection. tumor extends to within 2 mm of the superior margin, and does not approach The closely to any other margin. The remainder' of the breast consists of firm, white and tan admixed breast parenchyma. Tissue is divided into deep (towards chest wall) and superficial (towards skin) halves and submitted from medial to lateral as follows: BLOCK SUMMARY: C1 frozen section remnant cfl.. c2-C8  superficial half from medial to lateral.. c9-c15 deep half from medial to lateral. D. "Right axillary dissection and wide reexcision", fresh. The specimen consists of an excisional breast biopsy and attached axillary dissection. biopsy is incised, to obtain tissue for frozen section, ER/rr, and tissue  The bank, prior to receipt by pathology. The biopsy measures 6.7 x 6.5 x 3.2 cm.. The axillary tail measures 10 x 2.3 x 0.9 cm. The medial surface (not a true margin) is inked in red, the inferior margin black and the superior margin in blue. On cut section, there is a 4.5 x 2.3 x 2.5 cm white firm tumor, composed of the inked superior margin of resection and to within 1 cm of the superior and 5 mm of the inferior margin.. Tumor approaches to within 4 mm of the deep. margin of resection. The remainder of the breast is unremarkable The axillary dissection is divided into low, mid and distal level. There are numerous lymph nodes, ranging from 0.3 to 1.4 cm, none grossly involved by tumor. BLOCK SUMMARY: 1 of 2 se iscircle DISQUALIFIF Thye we +1311
+
+--- Page 2 ---
+D1-D5 Anterior (superficial) tumor from lateral to medial. D6-D10 Posterior (deep) tumor from lateral to medial. D11 - Lower lymph node candidate. D12 - One mid-level lymph node, bisected. D13 - Five mid-level lymph node candidates. D14 - Four distal lymph node candidates. D15 - Highest lymph node. E. "Left axillary dissection, silk on apex", fresh. The specimen consists of a 6 x 9 x 1.7 cm lymph node dissection, with a black suture at one pole. lymph node dissection is divided into three sections, lower, middle and The distal. Numerous lymph nodes are identified ranging from 0.3 to 1.7 cm in greatest dimension. None grossly contains tumor BLOCK SUMMARY: E1  Lower nodes, 3 lymph node candidates E2 Three lymph node candidates, lower node. E3 Middle nodes, 2 lymph node candidates. E4 Middle nodes, 2 lymph node candidates. E5 Three lymph node candidates, upper lobe. E6 Upper nodes, 1 lymph node candidate. E7 Upper node, 1 lymph node candidates, bisected. E8 Highest apical node. INTRA OPERATIVE CONSULTATION: AFl-Af3: "Medial margin right breast biopsy": Inked margin free of carcinoma. (KR). Bfl: "Right breast biopsy sample": Carcinoma Cf1: "Left breast biopsy": Carcinoma DIAGNOSIS: A. "MEDIAL MARGIN RIGHT BREAST BIOPSY": BENIGN BREAST TISSUE. B. "RIGHT BREAST BIOPSY": POORLY--DIFFERENTIATED ADENOCARCINOMA. C. "LEFT BREAST TUMOR, WIDE RE-EXCISION": INVASIVE AND INTRADUCTAL ADENOCARCINOMA 1.3 x 1.3 x 1.3 CM. NSABP HISTOLOGIC GRADE 3, NUCLEAR GRADE 3. NON-COMEDO TYPE INTRADUCTAL COMPONENT COMPRISES 5% OF TUMOR. VASCULAR SPACE INVASION IDENTIFIED (C13). INKED MARGINS OF RESECTION FREE OF TUMOR. EXTENDING TO WITHIN 1 MM OF INKED SUPERIOR MARGIN OF RESECTION (CI4). ASSOCIATED WITH MICROCALCIFICATION. REMAINDER OF BREAST WITH APOCRINE METAPLASIA AND MICROCYST FORMATION. D. "RIGHT AXILLARY RESECTION OF BREAST AND WIDE RE-EXCISION": INVASIVE AND INTRADUCTAL CARCINOMA. 4.5 X 2.3 x 2.5 CM. NSABP HISTOLOGIC GRADE 3, NUCLEAR GRADE 2. NON-COMEDO TYPE INTRADUCTAL CARCINOMA COMPRISES 5% OF TUMOR. INTRADUCTAL CARCINOMA EXTENDS BEYOND TUMOR MASS. VASCULAR SPACE INVASION NOT IDENTIFIED. TUMOR APPROACHES TO WITHIN 1OO MICRONS OF INKED MARGIN OF RESECTION REMAINDER OF BREAST WITH MICROCYST FORMATION AND FIBROADENOMATOUS CHANGE. 10 REGIONAL LYMPH NODES WITH NO TUMOR SEEN (O/1O). E. "LEFT AXILLARY DISSECTION": 8 LYMPH NODES WITH NO TUMOR SEEN (O/8). NOTE: FOCALLY, CAUTERY ARTIFACT EXTENDS TO TUMOR. /D91 Verified by: 2 of 2
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diff --git a/output/text/fa91d5e5-4e60-4d98-ba87-5ad6061d7403.txt b/output/text/fa91d5e5-4e60-4d98-ba87-5ad6061d7403.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b8ac76a05879bd0c66735069e98324a5d73d275c
--- /dev/null
+++ b/output/text/fa91d5e5-4e60-4d98-ba87-5ad6061d7403.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+IcD-0-3 Carcioma, mifHtnatng ductal, Nos 85oof3 c50.9 1/08/11 Ste+ breast, Nos. #:' Pathology Form Specimen Information Collected b Date: 1me Preserved by: Date: Time:  SPECIMENTYPE (#of samples provided+ Frozen Paraffin Block Blood/Serum/Plasma Slide Diseased  Normal Diseased Normal Diseased Norma! Diseased Normal x x Time to LN2 Time to Formalin Time to LN2 min min 3d min IOHEENLSACAMEAASPATHOLOGICAEDESCRIPTIONRELEPAASTRS Primary Tumor Organ Size Extension of Tumor Distance to NAT Hereay L.Sx N0 X cm cm Lymph Nodes # Examined Location # Metastasized A xille 0 Distant Metastasis Detailed Location Size Organ M Pathological Staging No m o Stage: ILA pT 9 Notes:  UUID: 76F67AA2-4E17-48F5-810B-E4F4338902DC TCGA-C8-A12M-01A-PR Redacted 4
+
+--- Page 2 ---
+#: Microscopic Description yHistologicalPattern Structural Pattern Cell Distribution Streaming  Diffuse Storiform Mosaic + Fibrosis Necrosis  Palisading Lymphocytic Infiltration  Cystic Degeneration Vascular Invasion Bleeding Clusterized  Myxoid Change  Alveolar Formation  Psammoma/Calcification Indian File Cellular Differentiation + Lymphomatous + Adenomatous +  Sarcomatous  Squamous  Round Cell Large Cell Glandular cel! Squamoid Cell Small Cell Cell Stratification  Fibroblast Spindle Cell Osteoblast  RS Cell/RS Like Keratin Secretion  Lipoblast Inflam. Cell Intracyt. Vacuole  Desmosome  Plasma Cell Gland formation  Myoblast  Pearl  Poor Well  Moderate Cellular Differentiation: sms NuclearAppearanceuwzoe 1 II III 0 Nuclear Atypia:  Aniso Nucleosis * + Hyperchromatism Nucleolar Prominent  Multinucleated Giant Cell  Mitotic Activity + Nuclear Grade: Value Date  Result Marker  Negative  Positive ER PR Negative  Positive  Negative  Positive Her-2/neu  Negative  Positive  B-Cell Marker Negative  Positive T-Cell Marker  Negative  Positive Other:  Negative  Positive Other: Final Pathology Report Ductal careiwma Histological Diagnosis: Grade: Comments: Date Pathologist  Principal Investigator
+
+--- Page 3 ---
+COnSOLIDATED DIAgNOSTIC PAThOLOgy fORm* Microscopic Appearance: J. Histological pattern: CELL DISTRIBUTION Diffuse + STRUCTURAL PATTERN Mosaic XStreaming + Necrosis & Storiform Lymphocytic Infiltration Fibrosis Vascular Invasion Palisading Clusterized Cystic Degeneration Alveolar Formation Biceding. Indian File Myxoid Change 2. Cellular features: Psammoma/Calcification Squamous + Adenomatous Squamoid Cell Sarcomatous Glandular cell Lymphomatous  Round Cell Spindle Cell Large Cell Cell Stratification Fibroblast Keratin Small Cel! Secretion Osteoblast Desmosome Intracyt. Vacuole  RS CeIV/RS Like *  Lipoblast Pearl Inflam. Cell  Gland formation x Myoblast Otherwise Specified: Plasma Cell Dr 8 Neerss X 2. Cellular Differentiation: Well Moderately Poor Nuclear Atypia:  Nuckear Appearance Aniso Nucleosis II Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity 4 Nuckear Grade Histological Diagnosis: TopUse/y Detal Cucre MO Comments: An . AA Date PATHOLOGIST STAFF FOR RESEARCH USE ONLY). SRATED REPORT OF FINDINGS BY CONTRIBUTOR AND
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diff --git a/output/text/fab14834-4513-45ae-ac50-d26d2908b51e.txt b/output/text/fab14834-4513-45ae-ac50-d26d2908b51e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a12225db33f665c7a8018fa88fdcb282c4ffa882
--- /dev/null
+++ b/output/text/fab14834-4513-45ae-ac50-d26d2908b51e.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Clinical Diagnosis & History: None-given. Specimens Submitted: 1:SP:Kidneyleftradical nephrectomy 2SP:Lymph node,para-aortic,excision DIAGNOSIS: 1. SP:Kidney,left,radical nephrectomy Tumor Type: Renal cell carcinoma-Papillary type with sarcomatoid component. Fuhrman Nuclear Grade: High nuclear grade Tumor Size: Greatest diameter is 3 cm. The tumor is multinodular, the largest node measures up to 3 cm in greatest diameter. Local Invasion (for renal cortical types): Extends through renal capsule but confined within Gerota's fascia Involves renal sinus fat Renal Vein Invasion: Identified Surgical Margins: Free of tumor Non-Neoplastic Kidney: Unremarkable Adrenal Gland: Not identified Lymph Nodes: Number of metastatic nodes:1 Number of nodes examined:1 Staging for renal cell carcinoma/oncocytoma: pT3a Tumor invades the adrenal gland or perinephric tissues but not beyond Gerotas fascia Comment: reviewed the case and concurs with the diagnosis Page 1 of3
+
+--- Page 2 ---
+SP:Lymph node,para-aortic,excision Lymph Nodes Number of nodes examined:1 Number of metastatic nodes:1 The largest metastatic node is 3.0cm Perinodal (extracapsular) extension identified IATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL),AND THAT I HAVE REVIEWED ANDAPPROVED THIS REPORT. Special Studies: Result Special Stain Comment RECUT RECUT Gross Description: 1) The specimen is received fresh,labeled,Left kidney"It consists of a radical nephrectomy specimen measuring 22.0 x 10.0 x 3.7 cm and weighing 557 grams.Sectioning reveals kidney measuring 13.0 x 7.5x 3.0 cm.No adrenal gland is grossly identified.Segment of unremarkable ureter is noted,measuring 3.0 x 0.6 cm. The ureteral and vascular margins appear grossly negative and are sampled. The renal parenchyma reveals at the superior pole, a well circumscribed, multinodular, tan-gray, rubbery tumor,measuring 3.0 x 3.0 x 1.8 cm.Departing from the tumor and descending into the mid-portion of kidney and renal pelvic fat are other multiple smaller nodules, ranging in dimensions from 0.3 to 1.7 cm. Some smaller nodules reveal a tan-yellow soft friable cut surface. Some nodules appear to be included within the renal pelvic fat.The renal pelvic and calyceal system appears negative for lesions. The rest of the renal parenchyma reveals a well-defined cortical medullary junction with preserved architecture. Sectioning through hilar fat reveals no lymph nodes. Representative sections are taken. Section is taken for TPS and electron microscopy Summary of Sections: MARG-margin TM-tumor TMNS-tumor nodules NORM-normal kidney HYL-representative hilar fat TMPELF-tumor and pelvic fat NORMPEL-normalpelvis 2) The specimen is received in formalin, labeled,"Para-aortic lymph node"It consists of a pink-tan rubbery lymph node measuring 3.0 x 1.6 x 1.5 cm.Sectioning of the specimen reveals an indurated,tan-gray,cut surface,grossly suspicious for tumor.Representative section taken Summary of Sections LN-lymph node Summary of Sections: Part 1:SP:Kidney, left, radical nephrectomy Block Sect.Site PCS 2 HYL 2 1 MARG 1 Page 2 of3
+
+--- Page 3 ---
+SURGICAL PATHOLOGY REPORT 21 NORM 21 NORMPEL 5 TM 531 3 TMNS 1 TMPELF Part2: SPLymph nodepara-aortic,excision Block Sect.Site PCs 2 LN 2 Page 3 of3 END OFREPORT
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diff --git a/output/text/fac02794-3e33-45f4-bef9-de902ae477d5.txt b/output/text/fac02794-3e33-45f4-bef9-de902ae477d5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..4ee07cc262e44408c66d18ea9d2bea48b7e2660d
--- /dev/null
+++ b/output/text/fac02794-3e33-45f4-bef9-de902ae477d5.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+ICs-0-3 Can cin 0ma, nifiltnahng cluctel, Nos 85o0/3 ID#: Pathology Form Specimen Information Collected by: Date: Preserved by: Date . ime: Frozen  Paraffin Block Blood/Serum/Plasma Slide Diseased  Normal Diseased Normal Diseased Normal Diseased Normal 4 L 4 2. 4. 2 Time to Formalin Time to LN2 Time to LN2 min min min 12 POSSSTCAL PATHOLOGICALDESCRIPTIONCRNAPERW Primary Tumor Organ Size  Extension of Tumor Distance to NAT BRecsJ 6 timoR 25 x 2 xhScm cm Lymph Nodes # Metastasized Location # Examined Distant Metastasis Organ Detailed Location Size Pathological Staging m 0 N! Stage: I pT 2 Notes: BRecsT^noc/e8 4 ( 3 N&ge7ire, 1 frosiTive. UUID: 175224E6-3A06-4799-B695-704C254A847C Redacted TCGA-C8-A132-01A-PR
+
+--- Page 2 ---
+ID#: Microscopic Description wwHistologicalPattern. Cell Distribution + Structural Pattern +  Diffuse x Streaming  Mosaic  Storiform Necrosis Fibrosis  Lymphocytic Infiltration Palisading Vascular Invasion  Cystic Degeneration Clusterized  Bleeding  Alveolar Formation  Myxoid Change  Indian File  Psammoma/Calcification iemcellular Differentiationcars Squamous +- Adenomatous + Sarcomatous + Lymphomatous Squamoid Cell Glandular cell x Round Cell Large Cell Spindle Cell Cell Stratification Fibroblast Small Cell  Keratin  Secretion Osteoblast  RS Cell/RS Like  Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell  Pear! Gland formation Myoblast  Plasma Cell Well Moderate x  Poor Cellular Differentiation: awrrswNuclearAppearanceasa w Nuclear Atypia: 0 1 II III Aniso Nucleosis Hyperchromatism  Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity Nuclear Grade: Result Value Date Marker ER Negative  Positive PR  Negative   Positive Her-2/neu  Negative   Positive B-Cell Marker  Negative  Positive T-Cell Marker Negative Positive Other:  Negative  Positive Other:  Negative  Positive Final Pathology Report Thsltralirg suctal cercinoms Histological Diagnosis: Grade:7TT Comments: Date Principal Investigator Pathologist 5
+
+--- Page 3 ---
+COnsOLIdateD DIAgnOstic patholOgy fOrm* Microscopic Appearance: 1. Histological pattern: CELL DISTRIBUTION  Diffuse + STRUCTURAL PATTERN Mosaic 4 Streaming Necrosis Storiform  Fibrosis Lymphocytic Infiltration Vascular Invasion  Palisading Cystic Degeneration Clusterized Alveolar Formation Bleeding. Indian File Myxoid Change  Psammoma/Calcification 2. Cellular features:  Squamous Adenomatous +  Squamoid Cell Sarcomatous Glandular cell +  Lymphomatous Spindlc Cell  Round Cell Large Cell Cell Stratification Fibroblast  Keratin  Secretion Small Cell Osteoblast  RS CeIl/RS Likc  Desmosome Intracyt. Vacuole Lipoblast Pear!  Inflam. Cell Gland formation Myoblast  Plasma Cell Otherwise Specified: D1 3j~% Dr 2OA Dz7O7 Dg357.NeeRogrs Ts2 Cellular Differentiation: Well Moderately Poor 3. Nuclear Atypia: Nuclear Appearaace III Aniso Nucleosis Hyperchromatism Nucicolar Prominent Multinucleated Giant Cell F Mitotic Activity Nackar Grade Histological Diagnosis: Tnblta t Aststeu Cesme, rs, 3 Comments: A M, conmmo Metttted te LN Date PATHOLOGIST STAFF FOR RESEARCH USE ONLY). INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AND :E
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diff --git a/output/text/fb16b39c-f951-4bf1-92c7-3aa4cc4f8ec6.txt b/output/text/fb16b39c-f951-4bf1-92c7-3aa4cc4f8ec6.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f92b442981b38249b7058e5e088c0b9b54f455a1
--- /dev/null
+++ b/output/text/fb16b39c-f951-4bf1-92c7-3aa4cc4f8ec6.txt
@@ -0,0 +1,18 @@
+
+--- Page 1 ---
+(For Collection of Cancerous Tissue). Informed Consent I personally informed this patient that a specimen(s) would be collected to be used for research purposes. I reviewed the RESEARCH SUBJECT INFORMATION AND CONSENT FORM with the patient and answered any questions the patient had. The patient then signed the consent form as a free and voluntary act. A copy of this informed consent document will be retained at our institution. Name of Physician or Study Coordinator Signature Date Clinical Information Date of Birth (mm/dd/yyyy) Height Marital Status Race Temperature Gender Weight Blood Pressure Heart Rate ASHISTORY OFPRESENTILLNESS Symptoms: Weiqht loss j tined oy ealinc Clinical Findings: Performance Scale (Karnofsky Score):  100 Asymptomatic A80-90 Symptomatic but Fully Ambulatory   60-70 Symptomatic, in bed less than 50% of day  40-50 Symptomatic, in bed more than 50% of day, but not bed ridden   20-30 Bed Ridden Drug Dose Route Frequency Date (mm/dd/yyyy) To To To To To
+
+--- Page 2 ---
+SSPAST MEDICALHISTORYE Diagnosis/Disease/Disorder/Injury  Diagnosis Date Treatment Status Occupation: Environmental Hazards: Smoking History. Current Status. TYPE Packs/day Duration When Quit YES NO (yrs) (yr) Alcohol Consumption Current Status TYPE Drinks/day Duration When Quit  YES gNO (yrs) (yr) Drug Use Current Status TypE  Frequency Duration When Quit  YES NO (yrs) (yr FAMILYMEDICALHISTORYSSA Relative Diagnosis Age of Diagnosis. Result Test Result Date Test Dot. HIV  Positive: CEA  Negative  Positive: Negative Hep B Negative CA 15-3  Negative  Positive:  Positive:  Positive: CA 19-9 Hep C Negative  Negative  Positive: PSA  Negative  Positive: AFP  Negative  Positive: Other: Other:  Negative  Positive:  Negative  Positive: B/T Cell Markers:. 2
+
+--- Page 3 ---
+SSESSDIAGNOSTIC STUDIES  Study Results Date Ultrasound X-Ray CT Endoscopy A... A tumour in the Ascenoliugy Loler MRI  Biopsy CLINICAL DIAGNOSIS  Preoperative Clinical Diagnosis Location of Suspected Involved Lymph Nodes Location of Suspected Distant Metastasis Clinical Staging Date of Diaanosi T3 NO MO Stage: IA Treatment Information SURGICALTREATMENTE Procedure Date of Procedure H e xi saloetoons Primary Tumor Organ Detailed Location Size Clim lumer Y x 3 x Zcm Extension of Tumor Lymph Nodes Description Location of Lymph Nodes. # of Lymph Nodes Palpable, Non-Dissected Lymph Nodes Dissected Lymph Nodes Distant Metastasis Organ Detailed Location Size Surgical Staging Tz ND M O Stage: TA NEOADJUVENT THERAPY (Chemo, Radiation,Immuno,Hormonal, or Molecular) Dose Frequency Date (mm/dd/yyyy) Drug/Treatment Route To / To / / To / / / To / / To 3
+
+--- Page 4 ---
+Pathology Form Specimen Information Collected by: Date ime Preserved by: Dat ime: SPECIMEN TYPE# of samples provided Frozen Paraffin Block Blood/Serum/Plasma Slide Diseased  Normal Diseased Normal Diseased  Normal Diseased Normal 2 2 Time to LN2 'Time to Formalin Time to LN2 /2 min 3 min min Primary Tumor Organ Size Extension of Tumor Distance to NAT Colim tesner 6 4 x 3 x Z cmA<Cegg?iiG cm Lymph Nodes Location # Examined # Metastasized Distant Metastasis Organ Detailed Location Size Pathological Staging pT 3 N o m Stage: _I7 Notes: Nadey ( Mz, M.2, =legelice ) 4
+
+--- Page 5 ---
+Microscopic Description HistologicalPattern Cell Distribution + Structural Pattern +  Diffuse  Streaming Mosaic  Storiform  Necrosis Fibrosis  Lymphocytic Infiltration  Palisading  Vascular Invasion Cystic Degeneration Clusterized  Bleeding  Alveolar Formation  Myxoid Change  Indian File  Psammoma/Calcification a Cellular Differentiation Squamous + Adenomatous + - Sarcomatous + Lymphomatous + Squamoid Cell Glandular cell Round Cell Large Cell Spindle Cell Cell Stratification  Fibroblast Small Cell Keratin Secretion Osteoblast RS Cell/RS Like  Desmosome Intracyt. Vacuole  Lipoblast Inflam. Cell  Pear! Gland formation  Myoblast Plasma Cell Cellular Differentiation: Well Moderate Poor Nuclear Appearance Nuclear Atypia: 0 1 II III Aniso Nucleosis Hyperchromatism Nucleolar Prominent Multinucleated Giant Cell Mitotic Activity Nuclear Grade:  Marker Result Value Date ER  Negative   Positive PR Negative   Positive Her-2/neu  Negative  Positive  Negative  Positive B-Cell Marker T-Cell Marker  Negative  Positive Other:  Negative  Positive Other:  Negative  Positive Final Pathology Report w zhe colem Histological Diagnosis: DuCi D i cclen0c00iAumsG Grade:7 pinrlb C(ibconorliaTd) Comments: M, M2  Uegat'ue Pathologist 5
+
+--- Page 6 ---
+NSOLIdatED DIAgNOsTIC pAThOLOgy fORm* Microscopic Appearance: 1. Histological pattern: CELL DISTRIBUTION + STRUCTURAL PATTERN Diffuse Streaming XI  Mosaic XX  Storiform Necrosis Fibrosis Lymphocytic Infiltration  Palisading  Vascular Invasion X Cystic Degeneration Clusterized X Bleeding  Alveolar Formation x Myxoid Change Indian File X Psammoma/Calcification 2. Cellular features: Squamous + Adenomatous +  Sarcomatous + Lymphomatous + Squamoid Cell Glandular cell X Round Cell Large Cell  Spindle Cell Cell Stratification K Fibroblast Small Cell Osteoblast  RS CeIl/RS Like  Keratin Secretion  Desmosome Intracyt. Vacuole  Lipoblast  Inflam. Cell Gland formation  Myoblast  Plasma Cell Pear! D3 Otherwise Specified: 60% Dy. e o7r D;EO7 Ir6O% Neek[Y] 2.Cellular Differentiation: Moderately Poor Well 3. Nuclear Atypia: II HI Nuclear Appearance X  Aniso Nucleosis X Hyperchromatism Nucleolar Prominent X Multinucleated Giant Cell Mitotic Activity Nuclear Grade M, Mz :. omments: ATHOLOGIST STAFF FOR RESEARCH USE ONLY). *(INTEGRATED REPORT OF FINDINGS BY CONTRIBUTOR AN
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diff --git a/output/text/fb209647-9f0b-4ad0-ab79-85205aeb405e.txt b/output/text/fb209647-9f0b-4ad0-ab79-85205aeb405e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..eb89aff4d64dea38c2d3396501b2f74d97fcce70
--- /dev/null
+++ b/output/text/fb209647-9f0b-4ad0-ab79-85205aeb405e.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1cs -Q-3 Cascinons.mfiltnating duct..vos 85o0f3 S.tu: srbot, N05 C 50.9 UUID:8C4FE877-9986-4C73-9751-508953A874DC 3/31/11 TCGA-BH-A0hx-01A-PR Redacted FINAL DIAGNOSIS: Part 1: lymph node, Left axillary, sentinel node #1, biopsy --. A.* TWO OF THREe LYMPH NODES POSITIVE FOR METASTATIC CARC(NOMA (2/3) (s0e comment). B. Largest metastatic focus is o.4 cm (Slide 1fs). C. EXTRACAPSULAR EXTENSION IS IDENTIFiED (SIide 1FS). Part 2: Lymph node, Left axillary, sentinel node #2, Biopsy -  One Lymph NODe, nEgative FOr metastaTic CArcinOma (O/1) (see comment). Part 3: Breast, Left, total mastectomy -- A. TWO (2) FOCI OF INYASIVE CARCINOMA, LARGER TUMOR IS QUCTAL AND MEASUTE 2.5 CM IN GREATEST  Dimension, and the Smaller tumor is LobulAr and measures^1.0 cm in greatest Dimension (s00 comment). B LARger TUmOr nOTTinGhAm GRADE 3 (TUBULE fORmATiOn 3, NUCLEAR PLeOmORphISm 3, mITOTiC AcTIvITY 3; TOTaL SCORe 9/9). C.  SmALLER TUmOR NOTTinGhAm GRADe 2 (TUsULe fORmATION 3, nUCLEAR PLEOmORphISm 2, MITOTIC AcTivITy 1; total ScoRe 6/9). DuctaL cArcinomA in-situ (Dcis), nucleAr Grade 3, SOLiD type with COmeDO-type necrosis, D. COMPRISING 5% OF THE LARGER TUMOR. E. Resection margins are free of tumor. FOcal LoBuLAr CArciNomA In Situ anD aTypical LOBuLAr hypERpLASIA. FOcal atypical Ductal hyperpLasia. H. SCLeROSING ADEnOSIS AND FiBROcySTIC ChAnGES WiTH ASSOCIATED MICROCALCIFICATIOnS. ChAnges consistent wth previous core BiOpsy sites. 1. J  TUMOR IS ESTROGEN AND PROGESTERONE POSITIVE AND HER2/NEU NEGATIVE AS PER CORE BIOPSIES REPORTS. NIPPLE AND SKIN, NEGATIVE FOR CARCINOMA. Part 4: breast, Right, total mastectomy -  FLORID DUCTAL EPITHELiAL HYPERPLASIA AND COLUMNAR CELL CHANGE ASSOCIATED WITH A MIcROCALCIFICATIOns. B. SCLerosing ADenosis.  PSeUDOaNGIOmATOUs StrOmAl hYPERPLASIA. FiBrocysTic chAnges with Associated microcalcifIcations. E.  UNREMARKABLE NIPPLE AND SKin. Part 5: Lymph noDeS, Left AxILLAry, DIssecTiOn -- TWENtY LyMph NODES, NegATiVE fOR METAStATIC CARcInOmA (0/20) (see commont). SYNOPTIC - PRIMARY iNVASIVE CARCINOMA OF BREAST LATERALITY: PROCEDURE: Left Simple mastectomy LOCATION: Upper outer quadrant Lower outer quadrant SIZE OF TUMOR:  Maximum dimension invasive component: 2.5 cm  MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: TUMOR AGGREGATE SIZE: Yes Sum of the sizes of muttiple invasive tumors: 3.5 cm Tumor TyPe (invasive component): Ductal adenocarcinoma, NOs, Infiltrating lobular carcinoma HISTOLOGIC TYPE: Classical NOTTINGHAM SCORE: Nuclear grade: 3 Tubule formation: 3 Mitotic activity score: 3 Total Nottingham score: 9 Nottingham grade (1, 2, 3): 3 ANGIOLYMPHATIC INVASION: Yes DERMAL LYMPHATIC INVASION: CALCIFICATION: No Yes, benign zones Yes, malignant zones Tumor TYpe, in SItu: Solid DCIS admixed with invasive carcinoma Percent of tumor occupied by in situ component: 5 % SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No Distance of invasive tumor to closest margin: 5 mm SURG MARGINS INVOLVED BY IN SITU COMPONENT: No Distance of in situ disease to closest margin: 5 mm PAGETS DISEASE OF NIPPLE: Lymph nodes positive: No 2 Lymph nODeS EXAmiNeD: 24 METHOD(S) OF LYMPH NODE EXAMiNATION: H/E stain, Keratin stain SENTINEL NODE METASTASIS: ONLY KERATIN POSITIVE CELLS ARE PRESENT: Yes SIZE OF NODAL METASTASES: No Diameter of largest lymph node metastasis: 4 mm LymPh nODe mETASTASIS(-ES) WITH EXTRACAPSULAR EXTENSiON:E SKIN INVOLVED (ULCERATION): Yes No NON-NEOPLASTiC BREAST TISSUE: ADH, FCD T STAGE, PATHOLOGIC: pT2 n stage, pathologic: pN1a M stage, pathologic: pMX ESTrOgen reCepTOrs: positive PROGESTERONE RECEPTORS: positive HER2/NEU: zero or 1+ Comment: Nottingham grade is recorded for the ductal carcinoma. Nottingham score for the  lobular carcinoma is nuciear grade 2, tubule formation 3, and mitotic activity t for a
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diff --git a/output/text/fb2fcbdf-cc6e-43ad-92c6-b35a0abdd622.txt b/output/text/fb2fcbdf-cc6e-43ad-92c6-b35a0abdd622.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ad3f9137a9f71d840411c3f3c607519d8fa84f47
--- /dev/null
+++ b/output/text/fb2fcbdf-cc6e-43ad-92c6-b35a0abdd622.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+FINAL DIAGNOSIS: PArt 1: Left AXILLARy SEntinel Lymph nOde #1, BIOpSy - TWO LYMPH NODES, NEGATIVE FOR METASTATIC CARCINOMA (0/2) (see comment). part 2: breast, Left, segmental mastectomy -- A.  InVaSIVe DUctAL CArCiNOmA, nOTtINghAm GrADe 2 (TuBULe fORmaTiON 3, nUCLEAR GRADE 2, Mitotic Rate 1; total score 6/9).  INVASIVE CARCInOmA MEASUrES 2.2 Cm IN GREATEST DImEnSION. C.  DuctaL CArcinomA iN-SItu (DcIS), nucLEar gRadE 2, SOLiD type with COmedONecrOSIS. D.  DCIS IS PRESENT ADMIXED WITH INVASIVE COMPONENT AND COMPRISES <5% OF TOTAL TUMORS VOLUME E.  MARGINS OF RESECTION ARE NEGATIVE FOR INVASIVE CARCINOMA AND DCIS, INVASIVE CARCINOMA IS 5 MM FROM CLOSEST (POSTERIOR) MARGIN OF RESECTiON. F.  LYMPHOVASCULAR SPACE iNVASION IS IDENTIFIED. G.  Skin, negative fOr tumor. H. INVASIVE TUMOR CELLS ARE POSITIVE FOR ESTROGEN AND PROGESTERONE RECEPTORS AND EQUIVOCAL fOR hER-2/NEU WITH A SCORE OF 2+, AnD PER PREViOUS PATHOLOGY REPORT ( 1c0-0-3 SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST Carcnora, nfi1traHgg dutl,Nrs 85oo|3 LATERALITY: Left PROCEDURE: Segmenta! Sir: Brsst, nos. C5o.9 J3/1 s LOCATION: Not specified SIZE OF TUMOR: Maximum dimension invasive component: 2.2 cm MULTICENTRICiTY/MULTIFOCALITY OF INVASIVE FOCI:  No TUMOR TYPE (invasive component): Ductal adenocarcinoma, NOS NOTTInGHAm SCORE: Nuclear grade: 2 Tubule formation: 3 Mitotic activity score: 1 Total Nottingham score: 6 Nottingham grade (1, 2, 3): 2 ANGIOLYMPHATIC INVASION: Yes DERMAL LYMPHATIC INVASION: No CALCIFICATION: No TumOR TyPe, In SITu: DCIS admixed with invasive carcinoma Percent of tumor occupied by in situ component: 5 % SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: No Distance of invasive tumor to closest margin: 5 mm SURG MARGINS INVOLVED by IN SITU COMPONENT: No LYMPH NODES POSITIVE: 0 LYMPH NODES EXAMINED: 2 METHOD(S) OF LYMPH NODE EXAMINATiON: Keratin stain T STAGE, PATHOLOGIC pT2 N Stage, PatholOgIc: pN0(i-) m Stage, PAthOlOgIC: PMA ESTROGEN RECEPTORS: positive PROGESTERONE RECEPTORS:  positive HER2/NEU: 2+ Redacted UUID:4C942A1D-5382-43A6-9B96-5155CCDEEC34 TCGA-BH-A0AU-01A-PR
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diff --git a/output/text/fb54f9dd-4f1b-47ea-bc70-3040fd5839d9.txt b/output/text/fb54f9dd-4f1b-47ea-bc70-3040fd5839d9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..01adccc77de4b9c06d7bb8360613ca2e7587112a
--- /dev/null
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+1CD - 0- 3 ntrata dct NUy Cancii oma, 12/8/0 8500|3 Peh Sit Codu: brnst, cennalpnhr C 50.1 CQcF Sit: brisot,nos c50.9 TSS: SPECIMENS: A. NON-SENTINEL LYMPH NODE #1 B. RIGHT BREAST C. LEFT BREAST WITH AXILLARY CONTENTS UUID:06D417E8-68C2-408C-8A TCGA-E2-A153-01A-PR Redacted SPECIMEN(S): A. NON-SENTINEL LYMPH NODE #1 B. RIGHT BREAST C. LEFT BREAST WITH AXILLARY CONTENTS INTRAOPERATIVE CONSULTATION DIAGNOSIS TPA/FSA-non sentinel lymph node #1: Touch prep is negative for tumor; frozen section positive for metastatic carcinoma (0.4 cm). Diagnosis called by Dr. to Dr GROSS DESCRIPTION:S A. NON-SENTINEL LYMPH NODE #1  Received fresh, labeled with matching patient identifiers, are 2 lymph nodes, 1.1 x 1 x 0.5 cm (A2) and 1.3 x 0.7 x 0.4 cm (A1). A1 contains a 0.4 cm white area of discoloration. A2 is used for touch prep; A1 is submitted for frozen section. Specimen is submitted entirely. FSA1: frozen A1 A2: A2 B. RIGHT BREAST, NORMAL BREAST Received fresh, labeled with the patient's identification and "right breast, normal breast" is an oriented 1154 g. 27 x 17 x 7 cm mastectomy with 25 x 9.5 cm skin ellipse and 1.7-cm flat nipple. Ink code: Anterior/superior-blue,  anterior/inferior-orange, posterior-black. The specimen is serially sectioned into 12 slices with from medial to iateral with nipple in slice 6; no masses or lesions are identified. No lymph nodes are found. Representatively submitted. B1: slice 3, upper inner quadrant B2: slice 4, upper inner quadrant B3: slice 5, upper inner quadrant B4: slice 7, upper outer quadrant B5: slice 8, upper outer quadrant B6: slice 10, upper outer quadrant B7: slice 10, lower outer quadrant B8: slice 9, lower outer quadrant B9: slice 6, lower outer quadrant B10: slice 5, lower inner quadrant B11: slice 2, lower inner quadrant B12: slice 1, lower inner quadrant B13-B14: nipple and skin C. LEFT BRESAST WITH AXILLARY CONTENTS Received fresh labeled with the patient's identification and "left breast with axillary contents" is an oriented 1457 g.  29 x 22 x 7 cm mastectomy with 24 x 11.5 cm skin ellipse and 1.2-cm inverted nipple; there is a 0.7-cm nodule adjacent to the nipple and multiple skin lesions ranging from 0.2 to 0.4 cm. Ink code: Anterior/superior-blue, anterior/inferior-orange, posterior-black.  Specimen is serially sectioned into 12 slices from medial to lateral with nipple and slice 6 revealing, in slices 5-7 a 2.5 x 2 x 1.8 cm firm tan lesion located in the mid upper region which is 3.2 cm from the deep margin and 1.7 cm from the anterior margin (#1), 2.4 cm inferior to lesion #1, in slice 8, is a 1.7 x 1.7 x 1.5 cm firm tan mass located in the mid section, 5 cm from the deep margin and 1 cm from the anterior margin (#2), 3 cm superior to lesion #2 is a firm 0.7 cm nodule located in the upper mid-quadrant in slice 8 which is 4.3 cm from the deep margin and 1.3 cm from the anterior margin. Clips are identified in slices 6, 7, and 8; multiple axillary lymph nodes are identified. Representative sections.. C1-C3: slice 6, lesion #1 including both margins (clip). C4: slice 7, connecting tissue between lesions #1 and #2 C5: slice 7, lesion #2 (clip) C6: slice 8, lesion #2 (clip) C7: slice 8, tissue connecting lesion #2 and #3 (including #3) C8: slice 11, upper outer quadrant C9: slice 10, upper outer quadrant C10: slice 10, lower outer quadrant C11: slice 4, lower inner quadrant C12: slice 3, lower inner quadrant C13-C15: nipple and adjacent nodule C16: skin lesions C17: 5 lymph nodes
+
+--- Page 2 ---
+C18: 3 lymph nodes C19-C22: 1 lymph node each C23-C24: 1 lymph node DIAGNOSIS: A. LYMPH NODE, NON-SENTINEL, LEFT AXILLA, EXCISION: - METASTATIC CARCINOMA TO ONE OF ONE LYMPH NODE (1/1), MEASURING 0.25-CM WITH FOCAL EXTRANODAL EXTENSION. B. BREAST, RIGHT, MASTECTOMY: - LOBUEAR CARCINOMA IN SITU (E-CADHERIN NEGATIVE) - FIBROADENOMA (O.6-CM). COLUMNAR CELL CHANGES AND HYPERPLASIA WITHOUT ATYPIA, USUAL  DUCTAL HYPERPLASIA WITHOUT ATYPIA, MICROCALCIFICATIONS IN BENIGN DUCTS, FIBROCYSTIC CHANGES WITH FIBROSIS AND APOCRINE METAPLASIA C. BREAST, LEFT, MASTECTOMY WITH AXILLARY NODE DISSECTION: - MULTIPLE FOCI OF INVASIVE DUCTAL CARCINOMA, SBR GRADE 2, LARGEST FOCUS MEASURING 2.5-CME - INTERMEDIATE NUCLEAR GRADE, DUCTAL CARCINOMA IN SITU, SOLID AND CRIBRIFORM TYPES WITHE CENTRAL NECROSIS AND MICROCALCIFICATIONS - SURGICAL RESECTION MARGINS NEGATIVE FOR TUMOR - METASTATIC CARCINOMA TO TWO OF FORTEEN LYMPH NODES (2/14), LARGEST MEASURING 1.3-CM WITH EXTRANODAL EXTENSION - BIOPSY SITE CHANGES WITH FIBROSIS, GRANULATION TISSUE AND FOREIGN BODY GIANT CELL REACTION - SEE SYNOPTIC REPORT AND SEE NOTE NOTE: Multiple foci of invasive ductal carcinoma identified around the central region. One focus of tumor involves. nipple without skin ulceration. SYNOPTIC REPORT - BREAST Specimens Involved Specimens: A: NON-SENTINEL LYMPH NODE #1 C: LEFT BREAST WITH AXILLARY CONTENTS Specimen Type: Mastectomy Needle Localization: No Laterality: Left  Invasive Tumor: Present Multifocality: Yes WHO CLASSIFICATION  Invasive ductal carcinoma, NOS 8500/3 Tumor size: 2.5cm Tumor Site: Central Margins: Negative Tubular Score: 3 Nuclear Grade: 2 Mitotic Score: 1 Modified Scarff Bloom Richardson Grade: Necrosis: Absent Vascular/Lymphatic Invasion: None identified Lobular neoplasia: LCIS Lymph nodes: Sentinel lymph node and axillary dissection Lymph node status: Positive 3 / 15 Extranodal extension Micrometastases: No DCIS present Margins uninvolved by DCIS DCIS Quantity: Estimate 5% DCIS Type:  Solid Cribriform DCIS Location:Both associated and separate from invasive tumor mass Nuclear grade: Intermediate Necrosis: Present ER/PR/HER2 Results ER: Positive PR: Positive HER2: Negative Performed on Case:.
+
+--- Page 3 ---
+Pathological staging (pTN): pT 2 N 1a CLINICAL HISTORY: None given  PRE-OPERATIVE DIAGNOSIS: Left breast cancer Microscopic/Diagnostic Dictation: Pathologist, Final Review: Pathologist, Final: Pathologist, --
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diff --git a/output/text/fb68cd7f-b445-4618-a552-bf588e7546f0.txt b/output/text/fb68cd7f-b445-4618-a552-bf588e7546f0.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a95671ddef88b7c97184d03386f8634849b9f2b8
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+--- Page 1 ---
+TCGA-B3-3925 SPECIMEN A. Left renal mass CLINICAL NOTES PRE-OP DIAGNOSIS: Renal mass. FROZEN SECTION DIAGNOSIS cortical carcinoma, margins negative for tumor. GROSS DESCRIPTION A. Received fresh for frozen section and tissue. procurement labeled "left renal mass". It consist of a. partial nephrectomy with loosely attached perinephric fat. It consist of a rounded portion of renal cortical tissue the base of which measures 3.9 x 4 cm. No grossly evident tumor is present at the margin. This margin is inked black. On the surface of this specimen there is a protruding dome-shaped yellow tumor mass measuring 1.5 cm. above the surrounding renal surface. On section,. this corresponds to a soft dull tan yellow tumor measuring 3.1 x 3. 3.1 cm. On section it comes extremely close to the deep resection margin. Peripheral margins are grossly spared. The attached perinephric fat is without tumor nodules. A frozen section of the deep margin is performed. Samples are 'also taken for tissue procurement. Additional representative sections are submitted in 6. cassettes, following fixation. MICROSCOPIC DESCRIPTION Histologic type: Papillary renal cell carcinoma. Histologic grade (Fuhrman Nuclear Grade): 2. Primary tumor (pT): The tumor measures 3.1 cm. in maximum dimension and extends through the renal capsule and minimally into perirenal.
+
+--- Page 2 ---
+MICROSCOPIC DESCRIPTION fat, pT3a. Margins of resection: All margins negative for tumor. Regional lymph nodes (pN): Cannot be assessed.. Distant metastasis (pm): Cannot be assessed.. Vascular invasion: Negative.. Non-neoplastic kidney: No significant pathology.. 14, 4 DIAGNOSIS Left renal mass, partial nephrectomy - Portion of kidney with papillary renal cell carcinoma, Fuhrman grade 2, minimally extending into perirenal fat. All margins negative for tumor..
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diff --git a/output/text/fb764850-421a-4584-b10e-5cc6e7e775de.txt b/output/text/fb764850-421a-4584-b10e-5cc6e7e775de.txt
new file mode 100644
index 0000000000000000000000000000000000000000..43db0d6d67df68bda3d8c47f964ab33dbc70ef02
--- /dev/null
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@@ -0,0 +1,3 @@
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+--- Page 1 ---
+Sample ID . Diagnosis: Resected colon with an extensive, ulcerated, moderately differentiated adenocarcinoma of the colorectal type with infiltration of the pericolic fatty tissue, and measuring a max of 3.5 cm. Tumor-free local lymph nodes. Tumor-free colon resection margins. Tumor-free mesocolic amputation margin. Tumor classification: pT3 pN0 (0/18), pMX; G2, L1, V0, R0. /Cs-0-3 aclino caciomu, N058140/3 Sita: Sigmod csfon (pw CQcF) C18.7 3/30/1 TCGA-AA-A017-01A-PR Redacted Huttt
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diff --git a/output/text/fba50a9b-4a90-4381-9a48-24c4f4b04e2e.txt b/output/text/fba50a9b-4a90-4381-9a48-24c4f4b04e2e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..dafa087246cc14983eab2320af293f18fafb483b
--- /dev/null
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+--- Page 1 ---
+TcD-o-3 Carciroro, adrenol erthci] Patient Name: 837013 Site: BAdrenal Gbnd Cortex C74.Z Sex: Female At) 112s/13 UUID:39E300DC-C01F-46BC-AE4C-D834458F1FF7 Redacted Macroscopy One vessel containing a material immersed in formaldehyde solution, described as following: product of a right adrenal mass resection, weighting 555 g and measuring 14.5 x 11.5 x 6.5 cm, previously. sectioned. The external surface is light brown and irregularly shaped. The internal surface of the mass is characterized by a friable and moltilobulated light brown tissue, with yellow nodules (largest nodule measures 2 cm). Few hemorrhagic areas are evident. Conclusion: Product of right adrenal mass resection: Adrenocortical carcinoma with the following features: Largest diameter -- 14 cm .Weight-- 117 g :Nuclear grade (Fuhrman) -- high Diffuse architectural pattern -- present Clear cells in < 25% of the neoplasm -- not detected  Areas on necrosis -- present Mitotic count -- >5 in 50 H.P.F. Atypical mitosis -- present Capsular invasion  not detected Venous invasion -- present
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diff --git a/output/text/fbb9750c-09ea-41e0-89b8-476437202283.txt b/output/text/fbb9750c-09ea-41e0-89b8-476437202283.txt
new file mode 100644
index 0000000000000000000000000000000000000000..bf8adfe509b6dda9bc19f8a71b02c5f3ee0ee693
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+--- Page 1 ---
+page 1 / 1 Department of Cancer Pathology. Date Examination: Histopathological examination Internal invoice No. Cost of diagnostic procedure. Examination No.: Patient: XXX PESEL: XXX Age: Gender: Material: 1. Partial organ resection -- sigmoid colon. Unit in charge: Physician in charge: Material collected on: Material received Expected time of examination: Clinical diagnosis: Examination performed on: Macroscopic description: A 17 cm length of the large intestine with a fragment of the mesentery sized 19 x 6 x 1.5 cm. A cauliflower-shaped tumour sized 4.3 x 0.6 found in the mucosa. The lesion surrounds 1o0% of the intestine circumference and narrows its Iumen, is located 7 cm 7 cm away from the other one. The lesion macroscopically infiltrates the intestinal wall. Minimum side margin is 2.3 cm.. Microscopic description: Adenocarcinoma tubulare (G2). Infiltratio carcinomatosa tunicae muscularis priopriae. Excision lines clear of neoplastic infiltration. Lymphonodulitis reactiva lymphonodorum (NO vIl). Histopathology diagnosis: Adenocarcinoma tubulare coli. Tubular adenocarcinoma of the colon. (GI, Dukes A, Astler - Coller Bl, pT2, pNO). Compliance validated by: CONTACT YOUR DOCTOR WITH THIS REPORT!
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diff --git a/output/text/fbe83e74-e7d3-47f1-98bc-d2b9a7677c86.txt b/output/text/fbe83e74-e7d3-47f1-98bc-d2b9a7677c86.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b08eb734885f979f056eb3c4e7b157e532e93063
--- /dev/null
+++ b/output/text/fbe83e74-e7d3-47f1-98bc-d2b9a7677c86.txt
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+
+--- Page 1 ---
+UUID: 5285D974-2653-44CA-937D-5467EE399388 TCGA-BH-A5IZ-01A-PR Redacted Collection Date: FINAL DIAGNOSIS: Part 1: breast, Left at 1 O'clock, segmental mastectomy - A. InVasIve DUctaL CArcinoma WITh ABunDant LymphoID InFiltrate AND TUmOR nECROSIS.  nOt"tingham GraDe 3 (tuBuLe formatiON 3, nUcLear pLeOmOrphISm 3, mitOtIC Activity 3; Total score 9/9). C. The invasive tumOr measures 2.2 Cm In Greatest DimensiOn (gROss DescriptiOn). D. FOCAL DUCTAL CARCINOMA IN-SITU (DCIS), SOLID AND CRIBRIFORM TYPES, NUCLEAR GRADE 3, ADMIXED WITH INVASIVE COMPONENT AND CONSTITUTES <5% OF THE TOTAL TUMOR VOLUME. E. SURGICAL RESECTION MARGINS ARE NEGATIVE FOR INVASIVE CARCINOMA, CLOSEST ANTERiOR AT 0.4 Cm AnD CLOSESt POsteRIOR aT 0.5CM. F. FOCAL ATYPICAL DUCTAL HYP PERPLASIA G. FIBROCYSTIC CHANGES WITH DUCTAL EPITHELiAL HYPERPLASIA. H. PREVIOUS BIOPSY SITE CHANGES  THe iNVaSIVE TUmOR CELLS ARE POSITIVE fOR ESTrOGEN RECEPTOR AND NEGATIVE fOR PrOgesterone ReceptOr and negative for her-2 fish as per Previous patholOgy RepOrt PART 2: SENTINEL LYMPH NODE #1, LEFT AXILLA, EXCISION~ TWo Lymph nodes, negaTive for metastatic carcinoma (0/2). Part 3: Sentinel Lymph node #2, Left Axilt A, excision -  One Lymph node, negaTive for metastatic carcinoma (0/1). Part 4: Sentinel Lymph nOde #3, LEft AxILLA, eXcIsIOn -- One lymph node, negaTive fOr metastatic carcinoma (0/1). Part 5: Sentinel Lymph nOde #4, Left AxILlA, eXciSiOn -- S One Lymph nODe, negaTive fOr metastaTic Carcinoma (0/1). ite Part 6: non-sentinel Lymph node, Left axilla, excision -- A. One Lymph node, positive fOr metastatic Carcinoma (1/1). 8.  Largest focus Of metastatic tumor measures 0.6 Cm. C.  NO EXTRACAPSULAR EXTENSION NOTED. CASe synupsiS: EC SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST LATERALITY: PROCEDURE: Left LocatIon: Segmental SizE OF TUmOR: Clock position: 1:00 Maximum dimension invasive component: 22 mm MULTICENTRICITY/MUL TIFOCALITY OF INVASIVE FOCI: W TumOR Type (invasive component): No Ductal adenocarcinoma, NOS NOTTINGHAM SCORE: Nuclear grade: 3 C56.9 Tubule formation: 3 Mitotic activity score: 3 Total Nottingham score: 9. Nottingham grade (1, 2, 3): 3 W ANGIOLYMPHATIC INVASION: DERMAL LyMPHATIC INVASION: No CALCIFICATION: Not applicable Tumor type, in situ: No Cribriform Solid  SURGiCAL MARGINS INVOLVED BY InVASIVE COMPONENT: Percent of tumor occupied by in situ component: 5 %. No SURg MARGINS INVOLVeD by IN SITU COMPONENT: Distance of invasiva tumor to closest margin: 4 mm Lymph nOdes pOsiTive:  Na LymPh NODes eXAmINED: 1 6 mEThOD(S) Of Lymph nODE eXAmInATiON: SEnTINeL NOde mETASTASIS: H/E stain  NON-NEOPLASTIC BREAST TISSUE: ADH, FCD No T stage, pathologic: N Stage, PathoLogIC: pT2 pN1a M STAGE: EStROGeN RECEPTORS:  Not applicable PROGESTERONE RECEPTORS: positive, H-score: 170 HER2/NEU: negative, H-score: 0 HER2/NEU (FISH): unknown Not amplified UALIFIED) DiSQUALIFI
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diff --git a/output/text/fc0efdfa-0a0e-4cf9-9218-cbdf51b11836.txt b/output/text/fc0efdfa-0a0e-4cf9-9218-cbdf51b11836.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0d8e95302074c8c1b8d60405190b4227c61d7a9a
--- /dev/null
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+
+--- Page 1 ---
+Page 1 of 1 Reg#: Name: DOB User Name: Se ACCNNumber Order Test Code Order Test Name Last Updated ACCN Collected: SPF SP FINAL REPORT Updated SP FINAL REPORT|Source: HISTORY: Forty-year smoking history. Presents with approximate six-month history of progressiveiy increasing hoarseness. Has had some ongoing left-sided otalgia and dysphagia. Recent biopsy confirred invasive squamous ceil carcinoma. Epiglottis - permanent.. GROSS : "Epiglottis" Received in formalin in a small container are five pink-tan mucosal bits, 0.2 x 0.2 to 0.8 x 0.4 cm. Two fragments bisected. Entirely submitted in cassette 1A.. (ns) MICROSCOPIC DIAGNOSIS: Epiglottis, biopsy: Invasive noderateiy-differentiated squanous cell. arcincma and carcinoma in-situ. the signing staff pathologist, have perscnally. examined ard interpreted the slides from this case.. tClose
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diff --git a/output/text/fc256406-a519-4a84-9c1a-09b8f3f3ee10.txt b/output/text/fc256406-a519-4a84-9c1a-09b8f3f3ee10.txt
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index 0000000000000000000000000000000000000000..594b0b25669f034091f5f2fa178376c1249cc764
--- /dev/null
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+
+--- Page 1 ---
+Diagnosis: Resected colon with a moderately differentiated adenocarcinoma of colorectal type, measuring 2.5 cm in diameter, with infiltration of the tunica muscularis propria. Tumor- free lymph nodes in the region. Tumor-free colon resection margins. Tumor stage therefore pT2 pN0 (0/21) pMX; G2, L0, V0, R local 0.
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diff --git a/output/text/fc260bde-2060-4fe4-93fb-1bcb8ed6a89f.txt b/output/text/fc260bde-2060-4fe4-93fb-1bcb8ed6a89f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1d0dbf0022ab2a925b190049be77cb85902c6d8a
--- /dev/null
+++ b/output/text/fc260bde-2060-4fe4-93fb-1bcb8ed6a89f.txt
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+
+--- Page 1 ---
+1cs- 0 -3 Cavcnomu,n`fil+rahng duct, Nos 85oof3 Sit cnde: breost, Nos c50.9 1+/2if10 h Final Diagnosis Breast/right, total mastectomy: Infiltrating ductal carcinoma, Nottingham grade III (of III),. [tubules 3/3, nuclei 3/3, mitoses 2/3; Nottingham score 8/9], forming multiple (2) masses (central- -2.6 x 2.2 x 1.6 cm and upper inner quadrant--0.3 x 0.2 x 0.2 cm) [AJCC pT2]. Ductal carcinoma in situ, high nuclear grade, composes less than 5% of the tumor volume. Angiolymphatic invasion is absent. The non-neoplastic breast parenchyma shows nonproliferative fibrocytic changes and a fibroadenoma (0.3 x 0.2 x 0.2 cm). Biopsy site changes present. The tumor does not involve the nipple, overlying skin, or underlying chest wall. All surgical resection margins, including the deep margin, are negative for tumor (minimum tumor free margin, 1.4 cm, anterior margin, for the central tumor). Lymph nodes, right axillary non-sentinel, excision: Multiple (2 of 3) right axillary non-sentinel lymph nodes are positive for metastatic carcinoma. One of the positive lymph nodes shows focal extracapsular extension. Lymph nodes, right axillary sentinel, excision: Multiple (2) right axillary sentinel lymph nodes are negative for metastatic carcinoma. Blue dye is identified in right axillary sentinel lymph node No. 1. Blue dye is not identified in right axillary sentinel lymph node No. 2. Lymph nodes, right high axillary, excision: Multiple (5) right high axillary lymph nodes are negative for tumor. Lymph nodes, right mid/low axillary, dissection: Multiple (2 of 27) right mid/low axillary lymph. nodes are positive for metastatic carcinoma [AJCC pN2]. Residual right breast tissue, excision: Residual breast tissue shows non-proliferative fibrocystic changes. Breast, left, simple mastectomy: Benign breast parenchyma with proliferative fibrocystic changes, including a complex sclerosing lesion. Negative for malignancy. Additional left breast tissue, excision: Benign breast parenchyma with non-proliferative. fibrocystic changes; negative for malignancy. UUID:5654FC27-47D3-4C7F-A0E7-A586140991C2 TCGA-AR-A1AU-01A-PR Redacted
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diff --git a/output/text/fc6100ec-4c8e-4ee4-8598-8472a236174b.txt b/output/text/fc6100ec-4c8e-4ee4-8598-8472a236174b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ef16fd0bb0ad58c21ed63c40cfa409528cd247b8
--- /dev/null
+++ b/output/text/fc6100ec-4c8e-4ee4-8598-8472a236174b.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis: The material available is an invasive, moderately differentiated adenocarcinoma of the colon, G2, with penetration of all parietal layers pT3, with vascular infiltration L1, V1, with free resection margins locally R0 and free lymph nodes (pN0, 0 of 14). Remark: In Block D, the polyps were examined separately. They were found to be serrated adenomas with dentate form cylindrical epithelia and goblet cells, as well as bleeding in the stroma. The polyps did not show any evidence of invasive structures. Tumor classification: ICDO-DA-M 8140/3 G2 pT3, pN0 (0/14) Locally R0 M classification in oncology conference.
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diff --git a/output/text/fc829e14-a345-4f4a-9172-ebe948a64bc1.txt b/output/text/fc829e14-a345-4f4a-9172-ebe948a64bc1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f9f3253e87c73cbe4de0d35b4a129ba5d9296977
--- /dev/null
+++ b/output/text/fc829e14-a345-4f4a-9172-ebe948a64bc1.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+DIAGNOSIS: 1. Kidney, left tumor #1, biopsy: Papillary renal cell carcinoma, type I.. 2. Kidney, left tumor #2, biopsy: Papillary renal cell carcinoma, type I..  Kidney, left tumor #3, biopsy: Cystic dilatation and sclerotic renal parenchyma, no tumor seen. 4. Kidney, left tumor #4, biopsy:  Papillary renal cell carcinoma, type 1.  Renal parenchyma with chronic interstitial nephritis and hyalinization of the glomeruli.. 5. Kidney, left tumor #5, biopsy: Renal parenchyma with incipient lesion and renal cyst.. 6. Kidney, left tumor #6, biopsy: Renal parenchyma with sclerotic changes.. 7. Kidney, left tumor #7, biopsy: Renal cyst. NOTE: Immunohistochemical studies of specimen #4 with cytokeratin 7 and calretinin demonstrate a focus of tumor cells in the adjacent fat.
+
+--- Page 2 ---
+CLINICAL INFORMATION: Allocate Order to Brief Clinical History:  bilateral renal tumors with outside renal biopsy showing papillary. type I RCC Specimen Taken For PROcEDuRE: Pre-Operative Diagnosis: left renal tumors Post-Operative Diagnosis: left renal tumors Operative Findings: 7 left renal tumors and cysts. removed SPECIMENS SUBMITTED: 1. TUMOR, Left rena! # 1 2. TUMOR, Left renal # 2 3. TUMOR, Left renal # 3 4. TUMOR, Left renal # 4 5. TUMOR, Left renal # 5 6. TUMOR, Left renal # 6 7. TUMOR, Left kidney # 7 GROSS DESCRIPTION: Received fresh in containers labeled with patient's name, medical record number,. and specified as follows are: 1.  "Left kidney tumor #1". It is a tan mass measuring 2.5 x 2.5 x 2 cm. The cut surface is tan to yellow with a focal area of hemorrhage. 50% of the tumor is procured for The specimen is received in. Pathology and matches the above description. The specimen is bisected and entirely submitted in white cassettes labeled #1A and #1B. 2. 'Left kidney tumor #2". It is a tan mass measuring 2 x 1.5 x 1.4 cm with a tan to yellow cut surface. 50% is procured for The specimen is received in Pathology and matches the above description. The. specimen is bisected and entirely submitted in a white cassette labeled #2.. 3. "Left renal tumor #3". It is a tan to yellow soft tissue fragment measuring 1 x 0.7 x 0.4 cm. 50% of tissue is procured for The specimen is received in Pathology and matches the above description. The. specimen is entirely submitted in a white cassette labeled #3.. 4. "Left kidney tumor #4". It consists of a tan mass measuring 5 x 5 x 4 cm with a tan to yellow homogeneous cut surface. 50% of the tumor is procured for. Additional tan to red fibrous soft. Patient Identification
+
+--- Page 3 ---
+tissue measuring 5 x 2.5 x 2 cm is also included in the container. The specimen is received in Pathology and matches the above description. Representative sections from the mass from which procurement took place are taken and placed into white cassettes labeled 4A-4C. Representative sections from the additional fibrous tissue are taken and placed into white cassettes labeled 4D and 4E. 5. "Left kidney tumor #5". It consists of tan soft tissue fragments measuring 1.7 x 1.7 x 0.6 cm. 50% of tissue is procured for  The specimen is received in Pathology and matches the above description. It is entirely submitted in white cassettes labeled 5A and 5B. 6.  "Left kidney tumor #6". It consists of yellow to tan soft tissue fragments measuring 0.4 x 0.2 x 0.1 cm. It is not procured. It is entirely submitted in a white cassette labeled #6. 7.  "Left kidney tumor #7". It is a tan soft tissue fragment measuring 0.9 x 0.4 x 0.4 cm. 50% is procured for The specimen is received in Pathology and matches the above description. It is entirely submitted in a white cassette labeled #7. Gross description dictated by Patient Identification
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diff --git a/output/text/fcadb6b5-a332-402e-be94-bb557aabe19c.txt b/output/text/fcadb6b5-a332-402e-be94-bb557aabe19c.txt
new file mode 100644
index 0000000000000000000000000000000000000000..af57349b0c0fbe701d47441afbe5eb1b6b079258
--- /dev/null
+++ b/output/text/fcadb6b5-a332-402e-be94-bb557aabe19c.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Other Related Data: Billing Type:. Financial Number: Clinical Diagnosis & History: female with large right renal mass, radical nephrectomy specimen. Specimens Submitted: 1: SP: Rt. kidney & adrenal 2: SP: Rt. gonadal vein DIAGNOSIS: 1) KIDNEY, RIGHT; NEPHRECTOMY: CHROMOPHOBE RENAL CELL CARCINOMA (9.7 CM). THE TUMOR IS CONFINED WITHIN THE RENAL CAPSULE AND ALL SURGICAL MARGINS ARE FREE OF TUMOR. 2) VEIN, RIGHT GONADAL; EXCISION: - UNREMARKABLE VEIN, NEGATIVE FOR TUMOR. NOTE: CASE REVIEWED AT INTRADEPARTMENTAL CONFERENCE. IATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON THE PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL) BY THE PATHOLOGIST WHOSE NAME APPEARS ABOVE MINE,AND THAT IHAVE REVIEWED AND APPROVED THIS REPORT Gross Description: 1)  The specimen is received fresh, labeled "Right Kidney and Adrenal". It consists of a nephrectomy specimen with attached perirenal fat. The ureter is 7.5 cm in length and 0.5 cm in diameter. The renal artery and vein are 1.5 and 1 cm in length and 0.6 and 0.8 cm in diameter. The specimen weighs 530 grams all together and measures 15 x 10 x 8 cm. There is a tumor mass in the middle portion of the specimen measuring 9 x 7.5 x 7.5 cm and it is bulging under the capsule to the lateral side of the specimen. This area is inked. After the perirenal fat is removed, the Page 1 of 2
+
+--- Page 2 ---
+specimen weighs 430 grams.  The specimen is bisected and in the middle portion of the kidney, which measures 14, 8 x 7.5 cm, a 9.7 x 9 x 7.5 cm tumor occupying the entire middle portion of the. kidney, occluding the hilar area is seen with a tan-yellow, light. brown color and areas of cystic degeneration. The tumor grossly involves the capsule, only three calices can be identified in the hilar area. The renal parenchyma measures 3 cm in greatest dimension in the areas which is not involved by the tumor. The tumor shows some multinodularity. Some of these nodules are. lighter in color than the surrounding tumor tissue. No definite adrenal gland is identified in the specimen.. Summary of Sections: SM - surgical margin of artery, vein and ureter. T - tumor C - capsule overlying the tumor TK - tumor with normal looking kidney tissue.  - hilar area K - normal looking kidney 2)  The specimen is received in formalin, labeled "Right Gonadal Vein". It consists of a portion of a vein measuring 1.3 cm in length and 0.5 cm in diameter. Entirely submitted in one cassette. Summary of Sections: U - undesignated Histo Stain Results/Comments: Stain/Procedure Name Result Comment RECUT ADDITIONAL H&E RECUT ADDITIONAL H&E Summary of Sections: Part Sect. SiteBlocks Pieces All 1 AG 1 M N c 3 M H 2 M K 1 M SM 1 M T 1 1 TK 1 } I 2 U 1 M Page2 of 2 END OF REPORT
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diff --git a/output/text/fcdb4020-7ee9-4100-acbb-920bd87b2074.txt b/output/text/fcdb4020-7ee9-4100-acbb-920bd87b2074.txt
new file mode 100644
index 0000000000000000000000000000000000000000..28c57177d169fd82fb9125a589d86850f93afd83
--- /dev/null
+++ b/output/text/fcdb4020-7ee9-4100-acbb-920bd87b2074.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+ics-0-3 Adunocerteiomv, N0s 8140/3 Sif Cu: Lecum C18,0 UUID: 879D9864-FDFE-4D40-A90A-2D8694148298 l TCGA-DM-A1D9-01A-PR  Redacted (First Tumor) Tumor Site: Cecum Proximal Date of Cancer Sample Procurement: Histology: Adenocarcinoma Description of other histology: Grade: Moderately Differentiated C Yes Mucinous:  No C Yes C Unknown (Focal) C Yes Signet Ring Feature: 6 No C Yes  Unknown (Focal) Histologic Heterogeneity: 6 No r Yes C Unknown Host Response: None Crohn's like reaction  None C Yes C Unknown Plasma cell rich stroma C No C Yes C Unknown C Expansile Growth Pattern: C Expansile  Invasive C Unknown and Invasive  Inflammatory Bowei Disease  No C Yes C Unknown Angiolymphatic Invasion:  No C Yes C Unknown Mutator Phenotype: 6 No C. Yes C Unknown Number of Slides 1 C Yes Garland Necrosis present: r No  Yes ( Unknown (Focal) TIL Cells / HPF 1.8 Pathologist Comment:
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diff --git a/output/text/fcf56081-bf99-43a0-a982-7b8bb46daab9.txt b/output/text/fcf56081-bf99-43a0-a982-7b8bb46daab9.txt
new file mode 100644
index 0000000000000000000000000000000000000000..133e53918449a96cd2e51267b376a219463add9f
--- /dev/null
+++ b/output/text/fcf56081-bf99-43a0-a982-7b8bb46daab9.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+A.K DKY.RICHT NEPHFECTOMY RENAcL. CARcINoA, chromophcbe type id cm)Fuhxman nuclear gradc II-11 of T, xrensivey inolving the renal. parenchyma (see Nor. Invadies into pexinephric adipoae tissue. Rena ven mretar anc perinephrie tat rocection margino are negative for No  finrive lymptovascular invasion identted. Adre al gland is n prcsent. Tumo cells aze positive for Haieg colloidal iron and cDio (multitocally. The unor is negative tor Rcc and wr-immunostains. The onneoplastic kicney is evaluated by Renal Patholcgy sexvice, and the Tim ng are reportei beiow. AJcc Classificatior.(6th edicion: NOTE The umor hos tynical rhromophobe rarcinoma cytol.ogy (weil-dfineo cel bord rs. perinuclear halcs, binucleaticn) as wei as focal pseudo- papillary arrh rertire, cyorin degeneretion and numerouo poammomatouscalciicats.one Cell cuitures were astempted but unsucgesstul and the cytogenetie analysis nor be perforred Civen the tnusual morphology and as oleo unsuccesstul. B. GIONAUREGHT RETROPERITONEAL LYMPH NODES ribx adiposc Lissue with no cumor prcsent. No 1 mpheid tssue present RENAPATIOLOOY EVALUATION OF KIDNEX PARENCHYMA: RIGH KIONEY.NEPHRECTOMY: MINTMAU CURONTC CHANGES OFTHE KIONEY PARENCHYMA WITH MLD ARTERIOLAR HYALINOSTS (SBE NOTE). NOTE Very mil chronic cnanges are presentinlding giobal glomeruloslerosio fe tiny dess tnan tt of glomeruii. tubular atrophy and intexstitiai ribrosis Afe tin lens than s of Fhe rortica parenchyme and mild arterioiar lyui moai scle ogic family hory of diabeten. MICR SCOPIC DESCRIPTION Sect ona of formalin-lixed, paraifin-embedded tissue (blcck A9) were evaluated mehenamine and Arxs ichrome tatns. Parc1ni
+
+--- Page 2 ---
+The anpl consict cf cortcx and meduila. There are al9 glomeruli prencnt, whic20.9axe glcbally sclerose. The remaining glomersl shcw no siqr..i.cant cxpanoion of ch aesangial arnas. Thare are no liccetnible craters  cubl contours o the qlomerua copillry wall banement membranes. Rare dintl tnbuleo contair. pas-positive hyaline casts and a few disnlay foca pron .nerces of reabsorptien granules. Less than s o che cartical paxenchyma show tmla acroghy and intezotitial ibrosis. Arterioles exhibit mild hyol.nos.. CHEN.CAEDATA: Clin.cel nistory: A 3s-yeay-old fomalc wich 13 cm zight renel mass. Operticr Pight xadical nephrectcmy. regioral lympharienectomy. opertivn Finding Hone given clin cal Diagnosis Righ rara man. TISS E SUBMITTED M. Right kidney 3/2. Regiorel righ. Tetxopexitoneal nodee GROS DESCRITTION: The penimen is rcceived fxeeh. in three parts, each labeled winn tne petient's .name unit number. Paxt A,right kineyconsists of s 20 gram gh radial nephrectomy rpcn men 2s.0x18.0x 12.0 includingkidney surronnding perirenal Cat and a po tion of Gerota Fascie up to 9.0 cm).Extonding txom hc xena palvjs is the eter (4. cm in length x 0.5 cm in diamecer.rena vein x.0 cm in Jeng Mx 2.0 cm n Janeter.an xenal artery (s.0 cm in length x c.4 cm in diam.ter.A very lag encapslated mass is idencified 1s.0 x 1a.0 x 12.0 cm and eplsces mos of tne rona parencnyma. it hes a tun/yelicw nnd mosrly cold nece ogenous cut sutae. with large oraan of honorrhage and ocal cystic dog:cration. i. ahrs the rcnal puivi and occupies a lazge portion o the Deriepnric tat.It cxcends to within 3.0 nm of the renal vein mrgin7.0 cm of tc ureter margi. and 5.0 cm t the renei artery margin. A rmal portion of s.sil renol prenchyma in pronen in the upper pole tlc residual Deivcaiiceal aysten ad adjacent parenchyma are mnrkedly distorted by the rome .Tne renal cort.ex is tan/brcwn with  welldeined cortico-medullary juncion. The adre gland is not identii. Thc adipose tissue is thinly sect.oned and no lyngh nodca are idniien. Rapresentacive sections ot thc tumo: mass are suhmttd for tacsue bonking and cytogenetics. Repronentative sect.cna f the noxl kidney arc cuhmttnd for eleocron microscony and immw otluorencance udie on hold).Gross photographa are taken. Micr Al Ranal vei, enal axtery and uretcr margins  fxege MiC Micr A7and A8 Tmo and adjacent normal kidneya txag Micx A9:Uninvolve kdney1 crag,Rss. Micr Ain-Al5addiional Lumor Lo inclui renal pelvismultiple frag. fibradiposeicoue 6.5 x4.3 x 0.5 cmwhich is thinly sectirned and no palpe al.e lymph nodc are identiien.Tn- specimen is cniroly ouomitted Micr B-5 tissunultiple frags By hi/hex signatur blow the senior phyiciun certities that he/she pexoaly conducted a microscopic xamnatio (qrcss only.exam if co otated) ottt dsscribed spcinenc and rendexed or coimd th diaqnostnes) related Lhereto.
+
+--- Page 3 ---
+Acce ision Nunber: Report status: Prcliminar Type gcal patrology Spec.men Type Proc durg Dote: Orda ing Provid PATH LOQIC DIAGNOSIS: Hel Fo: Immunohietochemistry and cytogenetico PREL MrNARy DIAGNosIs Renal celi carcinoma ihed tor cytogenetics and immchiarochemica stoina) Pathlogse CI.NCA DATA Histry Korkup tor sciarica found arg renal mass Operion Hand-asnisred laparonnopi nenhrctcmy. Cper tive Findinge Large righ renal man. clin.ca Diagnosis kanal cell cA mas. TISEE SUBMITTED Righ. kicney GROE DESCRIPTION: The jpacimen is recived rcch.labeled withthc paticnte name.unic number and 1.Right kidny. and consisr ot s73 ym rght nephrecomy soecimen 16 x 1lx cm.ncludnga kidney ls xi.bx 6.3 cm with atahed perirenal adipse up to 6.0 cm.A2.2 c renalartery idiameter 0.5ma 1.3 cm renal veir.idiametex 0.9 cm anda .s cm urecer 0.s cm are present at the hilum and re grossly unemarkable. Gerota's fascia has been previously partially inkelblack. The pecimen contains  well-circumscribed, can/yellow, hemc rnagic mass,which expands tc but does not grossiy invae the renal capelc at the lowrr role.2.s cm fzom the hilax vecsels. The perirenal tat. over the tumor is irely mobiie, without gross evidence of involvement. Repr sontative tumrr was Laken ror sM cylogcnctics, and cumox bank, and repr snative noral kidney was sent tor ,iF and rumor cank There is n adrs al gland present, and the remaining xenai tisouc is grossly unremarkable wicl.ut Acdiciona lesions or other abncrmalities. The renal pelvis is liks ige grossly unxemaxkable, lined by light can, trabecular mucosa without. abncmalty. MiCA. Vaculex,ureceral margins.3 txago, McrA Mas and closestinked adipose Eissue nrgin l Erug, MicrA Mac,1frag, MicrM Masr and adjacent.,uninvolved kidney, 3trags, Micx5 Mas and adjacent renal vein. 1 trag, MictA Vninvolved kidney, By k.s/hx signature below, the senior physician certifics that he/she per mal.ly conductd  microscopic examination (groos onlyexam it cc sated) f  described specimens and rendered or confirned the diagnosises) relo.ed Lhereto. Pagelf
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diff --git a/output/text/fcfc982d-1d50-4648-989c-0dff53c651eb.txt b/output/text/fcfc982d-1d50-4648-989c-0dff53c651eb.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fb8edef6fc16b8305eeba1cfb395033e7f695175
--- /dev/null
+++ b/output/text/fcfc982d-1d50-4648-989c-0dff53c651eb.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+Referring Physician:. UUID:9F7E2B98-29E7-465F-AE12-33D78FDFD71A0 TCGA-AC-A3OD-01A-PR Redacted DOB: Age: Gender:F Ref#: Hosp#:  Provider Group : Date of Service:. Date Received: Outpatient Case # Room: " Bed Date Reported: FINAL SURGICAL PATHOLOGY REPORT Diagnosis: A. breaSt, rIght, prophylactIc Mastectomy: - Atypical ductal hyperplasia, usual ductal hyperplasia, radial scai apocrine metaplasia and columnar cell change. - No carcinoma identified.. B. - E.) BREAST, AXILLARy LyMPH NODeS, LEft, MASTECTOmy AND SENTINEL LyMPH NODE BIOPSIES: - Invasive lobular carcinoma, grade 1.. - Tumor size: 50 mm. - Surgical margins negative.. C astnonr: 1cs-0-3 - One of three lymph nodes POSlTIVE for micrometastasis (1/3). - No extracapsular extension identified. PATHOLOGIC TUMOR STAGInG SyNOPSIS (LEfT bREAST): Type and grade (invasive): Invasive lobular carcinoma, grade 1. Primary tumor: pT2. Regional Iymph node: pN1mi (one Iymph node with micrometastasis, 1/3) C50.9 Distant metastasis: N/A. Pathologic stage: IIB. 1obulsv, Niis Lymphovascular invasion: Not identified. Margin status: R0, negative, all margins 10 mm or greater. COMMENT: A micrometastasis (measuring 1.95 mm in greatest dimension) is seen in sentinel lymph node. . Additionally, isolated tumor cells are seen in sentinel lymph node 8520/3 Breast Invasive Tumor Staging Information (AJCC Cancer Staging Handbook. 7th Ed, and CAP protocol. This staging also incorporates. Previous biopsy: Breast profile: ' Case #. Page 1 Printed: This report continues... (FINAL). Phone. Acct No. - Patient Nam K Patbology Repon - page 1/5
+
+--- Page 2 ---
+Case # Total breast including nipple and skin.. Specimen type: Total mastectomy Specimen procedure Sentinel lymph node. Lymph node sampling: Single intact specimen Specinen integrity: Left. Specimen laterality N/A. Specinen size (other than mastectomy) INVASIVE TUMOR FEATURES 50 mn. Invasive tunor size. 12:00. Invasive tumor site: Single targe tocus orinvasive carcinoma. Invasive tumor focality Histologic type Invasive lobular carcinoma Grade 1 (cumulative score 5 of 9). Total Nottingham Grade: Less than 10% (3 ofj3). Tubule formation: Nuclear Pleomorphism: Low grade (1 of 3). Mitotic count for Nottingham: Low (1 of3) One mitosis per ten high power tield. Mitotic count: Other Grading System: N/A. Lymphatic invasion: Not identified. RO,negative MARGIN STATUS FOR INVASIVE COMPONENT: Distance of tumor from margins: Deep at 17 mm. Closet margin: All other margins 20mm or greater. Other margins: Not identified. DUCTAL CARCINOMA IN-SITU (DCIS): Not identified. LOBULAR CARCINOMA IN-SITU (LCIS): Skin: Present, not involved. Prasent, not involved. Nipple: Not identified. Skeletal Muscle: Micrometastasis seen in one of three lymph LYMPH NODES: nodes,additionally one lymph node with isolated tumor cells.  INVASIVE PATHOLOGIC TUMOR STAGING (pTNM) Primary tumor (pT): pT2. Regional lymph nodes (pN):  pN1mi (1/3 tymph nodes with micrometastasis). Distant metastasis (pM): N/A. 118. Pathologic stage RECEPTOR STATUS AND HER2/NEU POSITIVE (100% postive cells, strong intensity) Estrogen receptors: POSITIVE (100% positive cells, strong intensity). Progesterone receptors: Negative (1+, scale,0-3+). Her2/neu: Ki-67 proliferative index. Intermediate (15%t celis). Page 2 Case # This report continues . (FINAL) Printed: Phone. Acct No Patient Namt Pathology Report - Page 2/5
+
+--- Page 3 ---
+Case #: FINAL SURGICAL PATHOLOgy REPORT NIA. Comment:  Atypical ductal hypgrpiasia (ADH), usual ductal Additional pathologic tindings hyperplasia. apocrige metaplasia, columnar cell change,! Signed by Source of Specimen: A.Right breast B. Left axillary sentinel ymph node # C. Left axillary sentinel lymph node # D. Left axillary sentinel lymph node # E. Left breast Clinical History/Operative Dx: Left breast malignant neoplasm unspecified site Intraoperative Diagnosis:  No tumor cells identiftied 3. Touch imprint-8: Lelt axillary sentinel lymph node # The intraonerative internretation(s) was/were performed and rendered at: No tunor cells identifiep C. Touch imprint-C: Left axillary sentinel lymph node # D. Touch imprint-D: Left axillary sentinel lymph node # No tumor cells identifiec Gross Description: A. The specimen is labeled right breast and is received in tormalin. It consists of a. mastectorny specimen which weighs 431 grams.A black suture marks the tail ot the breast.wth this orientation the specinen Page 3 Case #: This report continues.. (FINAL) Printed: Phc Acct No Patent Name Mhatna Denart  Page 3/5
+
+--- Page 4 ---
+Case # FINAL SURGICAL PATHOLOGY REPORT  measures 15.5 cn trom medial to lateral, 14.8 cm froin superior to inierior, and 4.3 cm frgm superficial to  deep. There is an overlying 16 x 10 cm skin ellipse with a sharply delineated 3 cm areola and protuberant 1 cm nipple. The skin shows muitiple punctate areas of pale red discoloration which are 1 mm to 1.5 mm. No other skin lesions are identified. The anterior-superior margin is inked blue, the anterior-inferior nargin  is inked green, and the posterior margin, which consists of smooth fascial tissue. is inked black. The breast. is serialy sectioned at close intervals to reveal lobutated fatty tissue and scattered tan-white tibrous to finely nodular breast parenchyma. There are no areas which have a stellate or retracted eppearance suggestive of neoplasm.No lyrnph nodes are identified within the lateral portion of tne bjeast Representative sections are submitted. Section summary A1) nipple and tissue just deep to nipple,. A2) representative skin, A3) representative tissue upper-inner quadrant,  A4) representative tissue lower-inner quadrant,. A5) representative tissue upper-outer quadrant A6) representative tissue lower-outer quadrant A7) representative centrai breast and central deep margin 8. The specimen is labeled left axillary sentinel lyrnph node # ... and is received without fixative.It consists of a 12 x 10 x 8 rnm lymph node. it is serially sectioned at close intervals and touch imprints are obtained. The node is submitted for permanent section in cassette 31. C. The specirnen is labeled lett axillary sentinel lympn node #. . and is received without fixative. It consists of a 10 x 8 x 7 mm lymph node. It is senally sectioned at close intervals and touch imprints are obtained. The specimen is submitted for permanent section in cassette C1.. ind is received withou fixative, it D. The specimen is labeled left axillary sentinei lymph node # consists of a 8 x 8 x 6 mn lymph node. The lymph node is serially sectioned at ciose intervals and louch imprints are obtained. The node is submitted tor permanent section in cassette D1.1 E. The specimen is labeled left breast and is received without fixative. It consisls of a mastectomy  specimen weighing 445 grams. A black suture marks the tail of the breast. With this orientation the  specimen measures 19 cm trom medial to lateral, 14.5 cm superior to inferior, and 4.2 cm from superticial to deep. There is an overlying 18 x 10.8 cm ellipse of pink-tan skin with a central inferiony located snarply circumscribed 3.5 cm areola and 0.9 cm protuberant tan nipple. The skin shows a few tiny punctate areas  of red discoloration which are up to 1.5 mm in maximum dinension. No other skin lesions are present. The anterior-superior margin is inked blue, the anterior-inferior margin is inked green, and the posterior margin, which consists of smooth tascial tissue, is inked black. The breast is serially sedioned to reveal a stellate retracted neoplasm in the central breast underying the nipple and superior areoja. This neoplasm measures 5 cm trom medial to lateral, 2.5 cm from superior to inferior, and 1.8 cm fromsuperticial to deep. It is 4.5 cn from the closest superior margin, 4.5 cm from the closest inferior margin, 7 cm from the closest lateral margin, 6.5 cn from the closest medial rnargin, and 1.7 cm from the closest deep margin. It. is 2 cn from the closest skin. Representative tissue from the neoplasm is obtained for research purposes. The remainder of the breast is composed of lobulated fatty tissue with scattered tan-whte tibrous. Page4 Case # Ths report continues.. (FINAL) Printed: Pho Acct No. - Patient Namt Page4 Pathology Report - Page 4/5
+
+--- Page 5 ---
+Case# FINAL SURGICAL PATHOLOGY REPORT parenchyma. There are no other areas grossly suspicious for neoplasm. There are no lymph nodes identified in the lateral portion of the breast. Representative sections are submitted. Section summary:. E1) nipple and tissue just deep to nipple, E2) lateral edge of neoplasm and closest deep margin (biopsy site in this area),. E3-E7) sections of turnor progressing from medial to lateral. E8) central deep margin underlying tumor, E9) upper-inner quadrant, E10) lower-inner quadrant, E11) upper-outer quadrant, E12) lower-outer quadrant. Microscopic Description:. A. Microscopic sectlons have been examined. The microscopic findings are reflected in jhe diagnosis rendered. 3. Microscopic sections have been examined. The microscopic tindings are retlected in the diagnosis rendered. Immunohistochemistry was perforned with adequale control for OsCAR keralin and shows positive staining for metastatic carcinoma. The tumor focus measures 1.95 mm in grealest dimension. No. extracapsular extension is identified. The touch preps prepared at the time of frozen section were reviewed and no definitive tumor cells are identified C. Microscopic sections nave been examined. The microscopic findings are reflected injthe diagnosis. rendered. immunohistochemistry was performed with adequate comtrol for OsCAR keratin and shows positive staining for isolated tumor cells D. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered. immunohistochemistry was pertormed with adequate control for QsCAR keratin and no metastatic carcinoma is identified. E. Microscopic sections have been examined. The microscopic findings are reflected in the diagnosis rendered. Case # Page 5 Printed Phon ENDOFREPORT (FINAL) Acct No. - Patient Name Pathology Report - Page 5/5 Page 5
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diff --git a/output/text/fd383e4d-dfb4-4203-a456-4dcc816af448.txt b/output/text/fd383e4d-dfb4-4203-a456-4dcc816af448.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a6cb48279f9bd9d0934d85a5b0fbc466d5e49f64
--- /dev/null
+++ b/output/text/fd383e4d-dfb4-4203-a456-4dcc816af448.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Formatted Path Report. D LARGE INTESTINE TISSUE CHECKLIST Specimen type:  Excision of tumor Specimen size: Not specified Tumor site: Sigmoid colon Tumor size: 3.5 x 3 x 3 cm Tumor features: None specified. Histologic type: Adenocarcinoma Histologic grade: Moderately differentiated Tumor extent: Submucosa Lymph nodes: 0/3 positive for metastasis (Regional 0/3) Margins: Not specified Evidence of neo-adjuvant treatment: Not specified Additional pathologic findings: Not specified Comments: None
+
+--- Page 2 ---
+Date of Procurement
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diff --git a/output/text/fd417968-0aa3-4e3c-ad4f-4fb9f90bc0c5.txt b/output/text/fd417968-0aa3-4e3c-ad4f-4fb9f90bc0c5.txt
new file mode 100644
index 0000000000000000000000000000000000000000..6d52a6f1f61d46ad998ae448e56a7695ea7b4b1e
--- /dev/null
+++ b/output/text/fd417968-0aa3-4e3c-ad4f-4fb9f90bc0c5.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+IcDO3 UUID:54C7EDE1-EDBE-44A4-A3BE-FD639D6891DA TCGA-DD-A4NL-01A-PR Redacted Carcinomo, hepatcellwlar !,oS 8j3dJ3 Sifes Lwer  C qQ.0 AO 12)24/1 TISSUE DESCRIPTION: A1 A2 A3 A4 A5 A6 Tissue from liver segment vI with portion of liver segment v (255.0 grams, 11.9 x 8.5 x 8.0 cm). DIAGNOSIS: Liver, segment vI with portion of segment v, resection: Well differentiated hepatocellular carcinoma forming a mass (3.6 x 2.1 x 2.1 cm). The surgical resection margins are uninvolved. See. comment. Seen in consultation wit'. Comment:  Reticulin stain shows loss of reticulin framework in the. carcinoma. Pri y umor ite Discr Pror Mgnancy History Synchronous Prin s(circle)
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diff --git a/output/text/fd440e77-1b19-4001-ba2e-46ae17b145ab.txt b/output/text/fd440e77-1b19-4001-ba2e-46ae17b145ab.txt
new file mode 100644
index 0000000000000000000000000000000000000000..271c8f672b72af4d913ec8732589e3fcdd344c56
--- /dev/null
+++ b/output/text/fd440e77-1b19-4001-ba2e-46ae17b145ab.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+P.1033 GNOSIS: y' aAxiLLary Sentinel Lymph node #1, right. biopsy -- ONE (1) LYMPH NODE. POSITIVE fOR METASTATIC CARCINOMA MEASURING 3.0 MM (SEE COMMENT). Part 2: AxilLAry Sentinel Lymph node #2, Right, BiOpSy - A. One (1) lymph node, positive for metastatic carcinoma. B.  InVASive fOCUS MEASUREs 4.0 Mm IN LArgeSt DImeNSION AnD WITh VEry fOCAL CAPSULE InvoLVEment. C.  LYmphovascular invasiOn noted. Part 3: AxiLLAry sentinel Lymph node #3:And #4, Right, BiOpsy - A. One (1) Lymph node, positive for metastatic carcinomA. B.  metAstatic TumQr MEAsUREs :6.0 mm In LARgeSt DImensIOn wItH fOcaL EXTracApSuLAR EXTENSION. C. FiBrOaDIpOSE TiSsuE: Part 4: Breast. Leet, total mastectomy - ACATYPICAL LOBULAR HYPERPLASIA INVOLVING SCLEROSING ADENOSIS. Rabtat ScAr WIth florid Ductal epithelial hyperplaSiA. C. EXTENSIVE SCLEROSING ADENOSIS. D. FiBrocystIC Change wITh DuctaL. EPITHeLiaL HyperpLASIA. E. COLUMNAR CELL CHANGE9.  InTrADUctal PAPILLOmAs. G.  MICROCALCIFICATIONS WITH ASSOCIATED ABOVE LESIONS. H.  NipplE, Skin, UnremarkablE. Part 5: breast, Right, modified Radical mastectomy - A.  Invasive Ductal Carcinoma, noTtingham grade 2 (tuBule formaTion - 3, nucLear Atypia -- 2. MitoTIc activity - 2; totaL score: 7(9). B.  InvAsive tumor measures 4.0 Cm in LArgest Dimension (GrOss measurement). C. DUctal carcinoma in Situ (Dcis), cribriform And SoLid types wIth fOcal Central necrosis. NUclear graDe 2. D. DCIs ACCOUntS FOR 15% OF THE tOTAL tUmOR VOLUmE. ADMIXED wITH InVASIVE COMPONENT. LYMPHOVASCULAR INVASION IDENTIFIED. F.  RE8ectiOn mArgiNs NEgATive fOR CarcinOmA (at LEast mORe tHan 2.0 Cm). ATyPICAL DUCTAL HyPERPLASIA. H. Atypical Losular hyperplasia. I. NOn-NeOpLAsTIC BReAst tiSsUe ShoWIng RaDIal ScAr. DUctal ePitHeLiAl hypeRpLASIa, SCLEROSInG ADenOSIS,-FIBrOCySTIC CHAnGE, COLUmnAR CELL CHAngE, AND iNTRADUCTAL PAPilLOmA. J.  InVaSIve CARcINOma IS MIXeD WITh RADIAl SCAR, SCLEROsINg ADeNOSiS. K.  MICROCALCIFICATIONS ASSOCIATED WITH INVASIVE DUCTAL CARCINOMA, DCiS. AND ABOVE BENIGN LESIONS. NiPpLe WiTH EpIdeRmAl INCLuSION CyST. NEgATIVE FOR CArcInOmA. M.  Biopsy site change. N. TWeNTY-FIVE (2S) LyMPH nODES, NEGATIVE fOR mETASTATIC CARcinOmA (0/25).  INVASIVE TUMOR CELLS ARE POSITIVE FOR ER AND PR AND NEGATIVE FOR HER-2/nCU  CASE SYNOPSIS: SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF RREAST Laterality: PROCEDURE: Right LOcATION: Modited radical mastectomy 1CD-0-3 Size OF tumOR: Not specifled MUL'rICENTRICITY/MULTiFOCALITY OF iNVASIVE FOCI:  Maximum dimension Invasive componnnt 4.0 cm TUMOR TYPE (InvasIve componcnt): No  NOTTINGHAM SCORE: Ductal adenocarcinoma, NOs Nurlear grade: 2 Tubule fomiation. 3 Mitolic activity srorc. 2 UUID:587CE4A4-E1D5-4D0B-B934-71894E32D782 Total Nottinyham score: 7 TCGA-BH-A0DI-01A-PR  Redacted ANGIOLYMPHATIC INVASION: Nottingham grude (1, 2. 3): 2 DERMAL LYMPHATIC INVASION: YH5 CAlCIfIcATIOn: No Tumor type. in situ: Yes, malignant zones Cribrifonn  SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: Solid Lymph nOdes ExAmineD: No METHOD(S) OF LyMPH NODE EXAMINATiON: 28 PAA Discr ricr Malign SENTINEL NODE METASTASIS: H/F stain ase circ t stage, pathologic: Yes N stage, pathologic: pT2 m stage, pathologic: pN1a Estrogen receptors:  pMX PROgesteROne rEceptOrS: pusitive HER2/NEU: postive zetu or 1+
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diff --git a/output/text/fd462e7e-aab6-49e2-b9ae-c8e17828d764.txt b/output/text/fd462e7e-aab6-49e2-b9ae-c8e17828d764.txt
new file mode 100644
index 0000000000000000000000000000000000000000..b40c6e148156b3b2ce9a71056a40274b4dd87a9f
--- /dev/null
+++ b/output/text/fd462e7e-aab6-49e2-b9ae-c8e17828d764.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+UUID:BED6A020-507B-41BD-8658-C092DBC9F369 TCGA-UD-AABY-01A-PR Redacted Request : Service Date : Requested by : Sex: Male DOB : Service Time : CYTOLOGY LABORATORY NUMBER: SPECIMEN: PLEURAL EFFUSION. MACROSCOPIC: 500ml of translucent yellow/orange fluid received. Two alcohol fixed smears and two air dried smears prepared.. MICROSCOPIC: The smears are highly cellular and contain numerous balls and crowded clusters of cells in a background of histiocytes, mesothelial cells and lymphocytes. The cells within the balls have small oval nuclei. Some cell in cell clustering is present..  Occasional cells have vacuolated cytoplasm.. In some of the papillary clusters there is a central core of fibrous tissue. The cell block is also cellular and contains numerous clusters of cells, some of which have a central fibrous core.  Immunoperoxidase staining for Cytokeratin and EMA are positive and for CEA is negative. The cells contain glycogen and mucin is not seen.. Report Data Request : Service Date : Sex: Male Service Time : DOB: CONCLUSION: The cytologic features are those of a malignant effusion and are consistent. with malignant mesothelioma. A portion of the specimen has been reserved in glutaraldehyde and will be sent for electron microscopic confirmation of the diagnosis. Pw TSS, 1ou'?o spihelioid. A Ce ICD-0-3 90e2|3 malgiant Nesstelisna makgrnt 9sol C38.4 Site: PLuwo NoS 1Z P 2/4
+
+--- Page 2 ---
+From: To: Anatomical Pathology ELECTRON MICROSCOPY LAB. NO. : Patient ADDRESS SEX : M WARD D.O.8. Request DaTe : DOCTOR CONSULTANT SPECIMEN: Pleural fluid ELECTRON MICROSCOPY: As noted in the cytological preparations, there are clusters of mesothelial cells, sometimes. associated with a central collagenous core, forming small papillary structures. The cells have. moderately irregular nuclei and some possess prominent nucleoli. The free surfaces of the cells show well-formed, long and thin microvilli devoid of glycocalyx and lacking any filamentous. core rootlets. These microvillous are slender, wavy and often branched. Apically the cells are. joined by well formed junctional complexes. In the cytoplasm, there are perinuclear. intermediate filaments arranged as tonofilaments and some of these insert into well formed desmosomes. There are small collections of rosetted glycogen in the cytoplasm. Other. organelles are non-specifically distributed. There are no mucin granules evident.. CONCLUSION: Pleural fluid -- The ultrastructural characteristics are in keeping with a malignant mesothelioma. PATHOLOGIST:
+
+--- Page 3 ---
+V4.00 TCGA Pathologic Diagnosis Discrepancy Form JInstructions: The TCGA Pathologic Diagnosis Discrepancy Form should be completed when the pathologic diagnosis. documented on the initial pathology report for a case submitted for TCGA is inconsistent with the diagnosis provided on the. Case Quality Control Form completed for the submitted case. Tissue Source Site (TSS): TSS Identifier: .. . TSs Unique Patient Identifier:. Completed By (Interviewer Name on OpenClinica):. Completed Date: Diagnosis Information Data Element Entry Alternatives Working Instructions Provide the diagnosis/ histologic subtype(s) documented on  Pathologic Diagnosis ndt speci6ea the initial pathology report for this case. If the histology for. Provided on Initial this case is mixed, provide all listed subtypes.. Pathology Report Histologic features of  Provide the histologic features selected on the TCGA Case epitheliod. Quality Control Form completed for this case. the sample provided for TCGA, as reflected on the CQCF. Discrepancy between Pathology Report and Case Quality Control Form Provide the reason for rovide a reason describing why the diagnosis on the initial  the discrepancy Onginal patholcgy report pathology report for this case is not consistent with the  between the pathology  diagnosis selected on the TCGA Case Quality Control Form. report and the TCGA was made upon a Case Quality Control Form. Cytology specimen No ofRca1 patho\ogy report issued'tor biopsy Review of ff pe by patno\ogis+ detennned his?ology to be ep+hqh@l.  Name of TSS Reviewing Provide the name of the pathologist who reviewed this case for TCGA.  Pathologist or  Biorepository Director I acknowledge that the above information provided by my institution is true and correct and has been quality controlled.. TSS Reviewing Pathologist or Biorepository Director Date I acknowledge that the above informatlon provided by my institution is true and correct and has been quality controlled. The Attending. Pathologist or the Department Chairman has been informed or is aware of the above discrepancy in diagnoses.. Principal investigator Signature Date
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diff --git a/output/text/fd4bbe20-0b0b-4729-bb8f-0333b1b9cb70.txt b/output/text/fd4bbe20-0b0b-4729-bb8f-0333b1b9cb70.txt
new file mode 100644
index 0000000000000000000000000000000000000000..06a231be1beb3019ef04ebd14706dff93b688b5c
--- /dev/null
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+
+--- Page 1 ---
+CGA-A6-2685 SPECIMEN Left colon CLINICAL NOTES PRE-OP DIAGNOSIS: Sigmoid colon cancer GROSS DESCRIPTION The specimen is received unfixed labeled "left colon" and consists of a colectomy specimen measuring 30 cm in length and 3 cm in diameter. There is abundant pericolonic fat. The entire specimen is 7 cm in diameter. The colon is opened with a single incision on the antimesenteric surface. There is a pink neoplasm. originating on the mucosal surface measuring 3.5 x 2.5 x 0.7 cm that. is 9 cm from one margin of resection. A portion of the specimen is. taken for research purposes. Sections after clearing and fixation. BLOcK sUMMARy: 1,2 - Margins of resection; 3-6 - tumor; 7-17 - lymph nodes.. MICROSCOPIC DESCRIPTION Tumor type: Colonic adenocarcinoma. Tumor grade: 2 out of 3 Tumor size: 3.5 cm. Distance to nearest margin: 9 cm. Level of penetration: Carcinoma penetrates through the muscularis propria into pericolonic soft tissue.. Margins of resection: Negative for malignancy.. Vascular invasion: Absent. Host response: Mild acute and chronic inflammation.. Attached lymph nodes: There is no evidence of malignancy. in any of twenty-nine pericolonic lymph nodes.. Non-lymph node pericolonic tumor: Absent. MICROSCOPIC DESCRIPTION pTNM Stage: T3 NO. Other findings:.  None. 5 3260F 153.3 DIAGNOSIS Colon, left, resection: Moderately differentiated colonic. adenocarcinoma. Note: Carcinoma invades through the muscularis propria into pericolonic soft tissue. There is no evidence of malignancy in any. of twenty-nine pericolonic lymph nodes.
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diff --git a/output/text/fd5a610f-5caf-4573-8443-eedecf210953.txt b/output/text/fd5a610f-5caf-4573-8443-eedecf210953.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1c90cc1baecf3fdc4974b6300cac0038be0d1da8
--- /dev/null
+++ b/output/text/fd5a610f-5caf-4573-8443-eedecf210953.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Clinical Diaanosis & History: ith incidantal Ieft ranal mass.  Incraasing in size past. Specimens Submitted: 1: SP: Kidnay, left tower pole, partial naphrectomy DIAGNOSIS: SP: Kidney, left lower pole, partial naphractomy Tumor Type:  Renal cell carcinoma - Conventional (clear cell) type Fuhnnan Nuclear Grade:  Nuclear grade II/IV Tumor Size: Greatest diameter is 1.5 cm. Local Invasion (for renal cortical types): Extands through renal capsule but confined within Garota's fascia Ranal Vain Invasion: Not identified Surgical Margins: Free of tumor Non-Neoplastic Kidney: Unremarkable Adrenal Gland: Not idantified Lymph Nodes: Not idantifiad Staging for renal cell carcinoma/oncocytoma: pT1 Tumor <= 7.0 cm in greatest dimansion limited to tha kidney Page 1 of 2
+
+--- Page 2 ---
+SURGICAL PATHOLOGY REPORT Gross Description: 1).The specimen is received fresh labeled, "Left lower pole partial nephrectomy" and consists of a resected, unoriented segment ot renal tissue measuring 4.5 x 2.5 x 2.2 cm. The perirenel fat is inked in black.* The specimen is opened to reveal a circumscribed yellow-tan glistening, homogeneous mass 1.5 x 1.5 x 1.2 cm. The mass grossly abuts the renal capsule. Further sectioning reveals diffuse areas of hemorrhage and fibrosis. The remaining renal parenchyma is unremarkable glistening brown-tan. A semple of the tunor is submitted for Representative sections submitted. Summary of sections:. TC-lumor with black inked capsule T-represent sectioning of tumor with adjacent unremarkable renel parenchyma Summary of Sections:. Part 1:  $P: Kidney, lelt lower pole, partial nephrectomy Block Sect. Site PCs 3 3 3 tc 3 Page 2 of 2 END OF REPORT
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diff --git a/output/text/fd64197a-69c0-497c-80fb-bdff7109eeb4.txt b/output/text/fd64197a-69c0-497c-80fb-bdff7109eeb4.txt
new file mode 100644
index 0000000000000000000000000000000000000000..20425b0b02166f769d6d8c183350b1fbe491bc50
--- /dev/null
+++ b/output/text/fd64197a-69c0-497c-80fb-bdff7109eeb4.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+Surgical Pathology Report. Name: Case #: DOb: Collected: Gendet: Received: MRN: Reported: Location: Copy To: Physiclan:d Pathclogic Interpretation: Ic D - 0 -3 SENTINEL NODE #1: Carcinoma mfi(traHry ductl Nos 85o0]/j A. - No carcinoma seen in one lymph node (0/1). Sife: brot, Nos c50.9 3/1a/n hw - Immunohistochemistry for keratin is pending. B. SENTINEL NODE #2: - No carcinoma seen in one lymph node (0/1) UUID:0D24479F-2F86-43AC-AA81-83AAD99542C4 - Immunohistochemistry for keratin is pending TCGA-EW-A1PF-01A-PR Redacted c. SENTINEL NODE #3: - No carcinoma seen in two lymph nodes (0/2). - Immunohistochemistry for keratin is pending. D. RIght;BreaSt, ONe StitCh SupERIOR, TWO StITChes LATeRAL: - INFILTRATING DUCTAL CARCINOMA, moderately differentiated, Nottingham grade 2 (2+3+2=7), 2.0 cm in greatest dimension.d - Margins are free of invasive carcinoma  Lymphovascular invasion is not identified.  Prior biopsy slte  See tumor summary.  DUCTAL CARCiNOMA IN SITU, high nuciear grade (DIN 3) with expansive comedo necrosis, solid type, present in 2/10 slides and representing less than 5% of submitted tissue. - Margins free of DCIS. E. NON-SENTINEL LYMPH NODE: - No carcinoma seen in two lymph nodes (0/2). F. SENTINEL NODE #4: - No carcinoma seen in one lymph node (0/1). - Immunohistochemistry for keratin is pending. G. SENTINEL NODE #5: - No carcinoma seen in one lymph node (0/1). - Immunohistochemistry for keratin is pending. H. SENTINEL NODE #6:  No carcinoma seen in one lymph node (0/1). - Immunohistochemistry for keratin is pending. I. SENTINEL NODE #7: - No carcinoma seen in one lymph node (0/1). - Immunohistochemistry for keratin is pending J. SENTINEL NODE #8: - No carcinoma seen in one lymph node (0/1). - Immunohistochemistry for keratin is pending TUMQR SUMMARY Specimen:d Total breast (including nippie and skin) Procedure: - Total mastectomy (including nipple and skin) Lymph Node Sampling:
+
+--- Page 2 ---
+SURGICAL PATHOL Report - Sentinel lymph node(s) - Axillary dissection (partial or complete dissection) Specimen Integrity: - Single intact specimen (margins can be evaluated) Specimen Laterality: - Right Tumor Site: Invasive Carcinoma - Upper outer quadrant - Central Tumor Size: Size of Largest Invasive Carcinoma - Greatest dimension of largest focus of invasion over 0.1 cm: 2.0 cm - Additional dimensions: 2.0 x1.0 cm Tumor Focality: - Single focus of invasive carcinoma Macroscopic and Microscopic Extent of tumor: - Skin: Invasive carcinoma does not invade into the dernis or epidermis - Skeletal muscle: Skeletal muscle is present and is free of carcinoma Ductal Carcinoma In Situ (DCIS): - DCIS IS PRESENT - Extensive intraductal component (ElC) negative Size (Extent) of DCIS: -Estimated size (extent) of DCiS (greatest dimension using gross and microscopic evaluation) is at least: 5 cm *Number of blocks with DCIS: 2 *Number of blocks examined: 10 - Architectural Pattens: Solid - Nuclear Grade: Grade IlI (high) - Necrosis: Present, central (expansive *comedo" necrosis) Lobular Carcinoma In Situ (LCIS)  Not identifed Histologic Type of Invasive Carcinoma: - Invasive ductal carcinoma (no special type or not otherwise specifed) Histologic Grade: Nottingham Histologlc Score Glandular (Acinar/Tubular Differentiation:  Score 2 Nuclear Pieomorphism: Score 3 Mitotic Count:  Score 2 Overall Grade: Grade 2: score 7 Margins: - Margins uninvolved by invasive carcinoma Distance from closest margin: 6 mm (deep) - Margins uninvolved by DCIS Distance from closest margin: 14 mm (deep) Treatment Effect: Response to Presurgical (Neoadjuvant) therapy: -In the Breast:  No known presurgical therapy - In the Lymph Nodes: No known presurgical therapy Lymph-Vascular Invasion: Not identifled. *Dermal Lymph-Vascular Invasion: Not identified Lymph Nodes: Number of sentinel lymph nodes examined: 9 Total number of lymph nodes examined (sentinel and nonsentinel): 11 Number of lymph nodes with macrometastases (>0.2 cm):0 Number of lymph nodes with micrometastases (>0.2 mm to 0.2 cm and/or >200 cells): 0 Number of iymph nodes with isolated tumor cells (s0.2 mm and s200 cells): 0 *Method of Evaluation of Sentinel Lymph Nodes: Hematoxylin and eosin (H&E), one leve! Immunohistochemistry pending Pathologic Staging (pTNM): pT1c N0 Mx Primary Tumor: pT1c Regional Lymph Nodes: pN0 Distant Metastasis: Not applicable Anclllary Studies: Estrogen Receptor:  Performed on another specimen : : Results: Immunoreactive tumor cells present (1%) Progesterone Receptor: - Performed on another specimen ): Results: Immunoreactive tumor cells present (1%) Page 2 of 5
+
+--- Page 3 ---
+SURGICAL PATHOL Report Her2: - Performed on another specimen ); Results: Negative AJCC c{sssification (7" od) (pTNM): pT1c N0 Mx 1D5-ER.Pg636-PRA485-HER2.H11-EGFR.Ai dies are anatye specific reagents (ASRs) validased ty our laborolory. These ASRs are clinically usefui inticators thas do nos reguire FDA appn oval. These clones are i pathologist a positive or negative. As the attending pathologist, I attest that I: (i) Examined the relevant preparation(s) for the specimen(s); and (ii) Rendered the diagnosis(es). ***Eiectronically Signed Out By*** Procedures/Addenda Adderdum Date Ordered: Status: Signed Out Date Complete: Date Reported: Addendum Piagnosis A: !mmunohistochemistry for keratin is negative. B: Immuhohistochemistry for keratin is negative. C: Immunohistochemistry for keratin is negative. F: Pending Immunohistochemistry (keratin). G: Immunohistochemistry for keratin is negative. H: Immunohistochemistry for keratin is negative. I: Immurohistochemistry for keratin is negative. J: Immunohistochomistry for keratin is negative. Intraoperative Consuitation A. Seninel node #1, FS: No carcinoma seen B.  Sentinel node #2, FS: No carcinoma seen C.  Sentinel node #3, FS: No carcinoma seen F. Sentinel node # 4, FS: No carcinoma seen G.  Sentinel node # 5, FS:  No carcinoma seen H.  Sentinel node #6, FS: No carcinoma seen I.  Sentinel node #7, FS: No carcinoma seen J.  Sentnel node #8, FS: No carcinoma seon MD Page 3 of 5
+
+--- Page 4 ---
+SURGICAL PATHOL Report Clinica History: None provided Operatlon Performed Right totai mastectomy with sentinel node and possible axillary dissection Pro Opprativo Dlagnosis: Right breast carcinoma Specin(en(s) Received: A: Sentinel node #1, FS B: Sentinel node #2, FS C: Sentipel node #3, FS D: Right|breast, one stitch superior, two stitches lateral E: Non sentinel lymph node F: Sentinel node # 4, FS G: Sentinel node # 5, FS H: Sentipel node #6, FS I: Sentinel node #7, FS J: Sentirel node #8, FS Gross Dencription: A. Received fresh is a yellow-tan tissue, measuring 1.6 x 1.1 x 0.2 cm. Bisected and submitted in toto in one cassette for frozen section. B. Received fresh is a tan-yellow tissue, 1.8 x 0.9 x 0.3 cm. Bisected and submitted in toto in one cassette for frozen. section. C. Received fresh are fragments of tan tissue, 3.1 x 2.1 x 0.3 cm.  Sections are submitted as follows: 1 Possible lymph node, bisected, for trozen section 2 Remaining tissue in toto D. Received in formalin is a total mastectomy weighing 450 grams, measuring 20.0 x 16.0 x 2.6 cm with a portion of skin 16.5 x 7.0 cm. The areola is 2.0 cm. in the upper outer portion of the breast 0.6 cm from the deep margin and 1.6 cm posterior to the skin at approximately 11 o'clock is an ill-defined fibrotic area 2.0 x 2.0 x 1.0 cm in dimenslon. No other lesions are grossly identified. Resection margins inked in black. Stroma to fat ratio is 5 to 95%. Sections submitted as follows: 1 Nipple (base of nippie) and tip in perpendicular sections 2&3 Composite section of the ill-defined mass in relation to the deep margin and to the anterior skin (Cassette 2 contains skin, cassette 3 contains deep margin) 4&5 Additional sections of lesion in relation to deep margin 6&7 Additional soctions of lesion in relation to surrounding breast tissue 8 Section from lower outer quadrant 9 Section from upper inner quadrant 10 Lower inner quadrant E. Received in formalin are multiple fragments of adipose tissue, 1.6 x 1.3 x 0.4 cm. The specimen is submitted in toto in one cassette. F. Received fresh is a tan-red tissue fragment, 0.9 x 0.6 x 0.2 cm.The specimen is bisected and submitted in toto in one. cassette for frozen section. G. Received fresh is a tan tissue fragment, 1.1 x 0.6 x 0.4 cm. The specimen is bisected and submitted in toto in one cassette for frozen section. H. Received fresh is tan tissue fragment, 1.1 x 0.6 x 0.3 cm.The specimen is bisected and submitted in toto in one cassette For frozen section.. Received fresh is a tan tissue fragment, 0.6 x 0.5 x 0.3 cm. The specimen is bisected and submitted in toto in one 1. cassette for frozen section. Page 4 of 5
+
+--- Page 5 ---
+SURGICAL PATHOL Report J. Received fresh is a tan tissue fragment, 0.7 x 0.4 x 0.3 cm. The specimen is submitted in toto in one cassette for frozen section. Page 5 of 5
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diff --git a/output/text/fd7452fe-732e-4dde-8b97-d6e65038aa71.txt b/output/text/fd7452fe-732e-4dde-8b97-d6e65038aa71.txt
new file mode 100644
index 0000000000000000000000000000000000000000..57643b5e33ac95ec15fc0bab6055d9da12758bc2
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@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Depariment of Pathology and Microbiology Namne: Accession No: Hosp No: AootNo! Date Takep: DOB: Ago! Date Received.: Stx: Submitted by: Client: Loc: Rooma Surgical Pathology Final Diagnosis: TAYROID, LEIT LONE, AESECTTON: THYROID GLAND HITA DIEEUSE LARCE B-CELL LOIPHOMA, NONCLEAVED CEUL TYPE, AND LYMPHOGYTIC THXRQIOITYS, Sigaed: (Bleotronio signature) History: Tho pAtiant io A year-old famala yith  kintoxy o Hashimoto's thyrolditis and left thyroid anlargegent.. Source/Gross: HEET CYROED Fregh tissus is racetyed in A contalnex labciied and designated *left tayroid." The apeoimen is A 1oba on tryxoia gland mensuring s.5  3.5  2.0 cn and yoighing 18,s gu. the capsuiar surftcs A4 pink and glisteniag. The capsniar suriace was inked prior to sectioning, and cho.paranchyua asn A nodulax tan to yhito appearance which. Anvolvr? axnriy' tne entire Xobe, with only a eaw acattared areas Of xesidual paroon thyroid partnchyma. A fxozen gection way perfoxosd. FROZEN SECTIOR DIAGNOSTS material present'. Diagnosis randered by and tegoxted to Dx. Ths pexuanent sscbion contirns the frozen seotion imoression ot adeguaco diagnoatie matarial. The specinen is auomittad as per the Lynphona $tudy Group Reorocol: Touch prepy dre nade - 3. Fixed in foamalin tor 2s hours - cassettes Al-n4. Frozen in Cr Sox Sumunohtstochemioal studleo - frozen gection Blouk. Placed sterilely in mediw tor cytogenetics - 1 pleca. Frosen in toil Iox molecular diagnostic studies - 3 toil Thaes materigls ers namned by allshose lited to eaiabuah ths diagnosi wih ho =ignaiure ins ths responstble siaffpathologis! 10f2
+
+--- Page 2 ---
+Name: Accossion No: Subroittd by: Date Taken. Hosp No: Surgical Pathology packets, each contalning appxozinately 2:3 k 1.5 x 0.3 cm of Hisyue qath. Elxed in 35 - cagsette A5. Theso matexlals yaxn axandnad by all thooe ldatsd to establish the diagnosio, witb the podereigned being the cosponstbla starn pataologlst. Gross dictated by: Mieroscopic: IMUNOPEROXIDASE REPORT PARAFFIN TISSUE 8-Cel1 Markoro R-call, Markeeo Othex Kaxkexe CD20(L26) + CD45RO{A6) ND CD45 (DCA) ND Cp79a AS(40 ND CD30 (ger-H2) MD CD10 + QD3 (3) Cp16 (teu M1) KD BCU-5 INTERERETNTION! Tho pezaftln Marxore Andicate a B-cell phanotype, Copy To: Othex Related Data: Location: 2 02
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diff --git a/output/text/fd7ab879-2082-4379-a487-a57a6b9bd692.txt b/output/text/fd7ab879-2082-4379-a487-a57a6b9bd692.txt
new file mode 100644
index 0000000000000000000000000000000000000000..ef1cb3dabcf3d36c6622b065d22add7251b90911
--- /dev/null
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@@ -0,0 +1,27 @@
+
+--- Page 1 ---
+UUID:91819D13-8938-4216-966F-930D9E0BF4E7 TCGA-GU-A763-01A-PR Redacted  Results BIOPSY OR SURGICAL SPECIMEN (Order Patient Information Patient Name MRN Sex DOB Male 1, Result Information Status Provider Status Edited Reviewed Entry Date Component Resultse Component Surgica! Pathology.. Lab Specimen IcD-O-3 Procedure/Addenda Image Analysis Date Ordered: 8/20|3 Status: Signed Out Date Complete: Date Reported: Sit olatrsIwolly wadder CCo%2 Interpretation HJ 8//3113 Prognostic markers performed on block M27 BLADDER CANCER RECURRENCE SCORE p21 by IHC and IMAGE QUANTITATION: Unaltered Percent Positive Average: 69% Staining Intensity Grade: 2 HistoScore: 7 p21 altered range (<10%) p27 by iHC and IMAGE QUANTITATION: Altered Percent Positive Average: 4% Staining Intensity Grade: 1. HistoScore: 3 p27 altered range (<30%) p53 by IHC and IMAGE QUANTITATION: Altered Percent Positive Average: 74% Staining Intensity Grade: 2 HistoScore: 7 p53 altered range (>=10%) Ki-67 by IHC and Image QUANTITATION: Altered Page 1 of I1
+
+--- Page 2 ---
+Percent Positive Average: 35% Staining Intensity Grade: 2. HistoScore: 5 Ki-67 altered range (>10%) Cyclin E by IHC and lMAGE QUANTITATION: Unaltered Percent Positive Average: 80% Staining Intensity Grade: 2 HistoScore: 7 Cyclin E altered range (<30%) INTERPRETATION: Prognostic Significance: Unfavorable 3 Biomarker(s) altered Range: Favorable < = 2 altered biomarkers Unfavorable > 2 altered blomarkers Comment: In the above tumor profile the number of altered biomarkers improves the predictive accuracy for patlents with PTa-T3 N0 Bladder Cancer. Greater than 2 altered biomarkers are assoclated with increased risk of recurrence.. Note: Staining intensity based on 0 (neg) to 3+ (highest) Percent Positive Average: Percentage of tumor cells staining. HistoScore = Percentage of tumor cells staining (Scale 0-5) + Intensity. (Scale 0-3 These tests were performed IHC in conjunction with automated image analysis. The performanre characteristics of the above tests have been. determined in the While some antibodies have not been approved by the FDA, clearance / approval Is not mandated. These antibodies are well documented and clinically accepted prognostic indicators. These tests should not be regarded as part of research investigations. Known positive and negative control tlssue show appropriate staining. The above tumor blo-markers were performed per reflex protocol. The system used for image quantitation is the The method used for antigen retrieval is heat induced epitope retrieval. College of American Pathologists (CAP) required information for predictive/prognostic markers. Type of specimen fixation and detectlon system: polymer detection kits are used on formalin-fixed paraffin-embedded sections. Page 2 of 11
+
+--- Page 3 ---
+Clones user: p21 (SX118); p27(SX53G8); p53 (DO-7); Ki-67 (MI8-1); Cyclin E (HE12)  Prognostic markers nerformed at. the Results-Commentse {Not Entered} Final Diagnosis A. Right ureter, ureterectomy:. - Reactive urothelium. - No dysplasia or carcinoma identified. - Frozen section diagnosis confirmed. B. Left ureter, ureterectomy: - Benign ureter - No dysplasia or carcinoma identified - Frozen section diagnosis confirmed. C. Left vas deferens, resection: - Fragment of vas deference with mostly denuded epithelium. D. Left internal and external iliac lymph nodes, dissection:. - Three lymph nodes, negative for tumor (0/3) E. Left obturator lymph nodes, dissection: - Three lymph nodes, negative for tumor (0/3) F. Left common iliac lymph nodes, dissection: - Five lymph nodes, negative for tumor (0/5) G. Preaortic lymph nodes, dissectlon: - Three lymph nodes, negative for tumor (0/3) H. Right common iliac lymph nodes, dissection: Page 3 of 11
+
+--- Page 4 ---
+- One lymph node, negative for tumor (0/1) I. Precaval and paracaval lymph nodes, dissection: - Six lymph nodes, negative for tumor (0/6) J. Presacral lymph nodes, dissection: - Two lymph nodes, negative for tumor (0/2) K. Right Internal and external lymph nodes, dissection:. - Two lymph nodes, negative for tumor (0/2) L. Right obturator lymph nodes, dissection: - Two lymph nodes, negative for tumor (0/2) M. Bladder and prostate, radical cystectomy and prostatectomy:. - Invasive, high-grade papillary urothelial carcinoma extending into prostate. parenchyma - Prostatic adenocarcinoma, Gleason score 7 (4+3) (See attached CAP template) - High-grade prostatic intraepithelial neoplasia  - Resection margins negative for tumor Specimen: Bladders Other (specify): Prostate, vas deferens, lymph node dissection, appendix. Procedure:  Radical cystoprastatectomy.. Tumor Site: Right lateral wall Prostatic urethra and prostate Tumor Size: Greatest dimension: 2.1 cm Histologic Type: Urothelial (transitional cell) carcinoma. Associated Epithelial Lesions: None identified Urothellal Carcinoma (WHO 2004/ISUP): HIgh-grade Microscopic Tumor Extension: Prostatic stroma Margins:  Margins uninvolved by invasive carcinoma. Lymph-Vascular Invasion: Not identified Pathologic Staging (pTNM): Primary Tumor (pTy' pT4a: Tumor invades prostatic stroma Regional Lymph Nodes (pN): pNO:  No lymph node metastasis. Specify: Number examined: 27 Number Involved (any size): 0 Distant Metastasis (pM): Not applicable Additional Pathologic Findings: Adenocarcinoma of prostate (see attached. separate CAP template) Ancillary Studies: Block M27 sent for ancillary studies, report to follow. Page 4 of 11
+
+--- Page 5 ---
+Procedure: Other (specity): Cystoprostatectomy Prostate Slze: Weight: Not available. Size: 3.8 x 3.1 x 3.0 cm Lymph Node Sampling: Pelvic lymph node dissection Histologic Type: Adenocarcinoma (acinar, not otherwise specified) Other (specify): Urothelial carcinoma (see above). Histologic Grade Gleason Pattern Primary Pattern: Grade 3 Secondary Pattern: Grade 4 Tertiary Pattern: Not applicable Total Gleason Score: 7 Tumor Quantitation Proportion (percentage) of prostate involved by tumor: 5% Extraprostatic Extension: Not identified Seminal Vesicle Invasion: Not identified Margins: Margins uninvolved by invasive carcinoma Treatment Effect on Carcinoma: Not identified. Lymph-Vascular Invasion: Not identified. Perineural Invasion: Not identified. Pathologic Staging (pTNM) Primary Tumor (pT): pT2a: Unilateral, involving one-half of 1 side or less.  Regional Lymph Nodes (pN): pN0:  No reglonal lymph node metastasis Specify: Number examined: 27 Specify: Number involved: 0 Distant Metastasis (pM): Not applicable Additional Pathologic Findings: High-grade prostatic intraepithelial neoplasia (PIN) Ancillary Studies: Block M20 can be used for further studies if needed. The above pathology diagnosis incorporates data elements as outlined in the CAP Cancer Protocols and Checklists which are based on the AJCC/uICC TNm, 7th edition. N. Appendix, appendectomy: - Obliterated appendix. - No malignancy identified O. Ureter, left distal margin, ureterectomy: Page 5 of 11
+
+--- Page 6 ---
+- Benign fragment of ureter. - No dysplasia or carcinoma identified P. Ureter, right distal margin, ureterectomy: - Benign fragment of ureter  - No dysplasia or carcinoma identified Note This case was reviewed at the. Clinical History Bladder cancer Radical cystectomy. prostatectomy, lymph node dissection ileal conduit. All other indicated procedures Source: A: Right ureter B: Left ureter C: Left vas deferens D: Left internal and external iliac lymph nodes E: Left obturator lymph nodes F: Left common iliac lymph nodes. G: Preaortic lymph nodes H: Right common illac lymph nodes I: Precaval and paracaval lymph nodes J: Presacral lymph nodes K: Right internal and external lymph nodes L: Rigt obturator lymph nodes. M: Bladder and prostate N: Appendix O: Left distal margin (ureter) P: Right distal margin (ureter). Gross Description Specimen A, received fresh labeied with the patient's name and designated "right. ureter", is an oriented tan tubular segment of tissue, 1.4 cm in tength and 0.4. cm in diameter. There Is a black silk suture at one end designated as distal per the surgeon. The opposing proximal end is submitted for frozen section as A1. Specimen B, received fresh labeled with the patient's name and designated "left ureter", is an oriented tubular segment of tissue, 1.5 cm in length and 0.4 in diameter. There is a Prolene suture at one end designated as distal per the  surgeon. The opposing proximal end is submitted for frozen section diagnosis as B1. 1 Specimen C, received in formalin labeled with the patient's name and designated "left vas deferens", Is a portion of adipose tissue, 3.6 x 2.0 x 1.1 cm. One surface is pink and glistening and serosalized. The opposing surface is focally hemorrhagic adipose tissue. Specimen is serially sectioned showing focally hemorrhagic adipose tissue and a tubular vessel, consistent with a blood vessel. A discrete vas deferens is not identified. There are two cramped edges. approximately 1.0 cm in length. The specimen is submitted entirely with the exception of the cramped edges at C1-C5.! Specimen , received in formalin labeled with the patlent's name and designated. "left internal and external iliac lymph nodes", is fragmented fibrofatty tissue, 7.5 x 6.0 x 2.0 cm in aggregate. There are three possible nodes and a tan Page 6 of 11
+
+--- Page 7 ---
+tubular segment of tissue. The nodes are 0.5 cm to 2.0 x 0.7 x 0.4 cm. The tubular segment of tissue is 4.0 cm in length and 0.6 cm in diameter. The Iuminous is pinpoint and ill-defined. The wall surrounding the lumen is white and fibrous, not resembling lymph node parenchyma. Representative sectlons are submitted as follows: Sectlon key: D1 two whole nodes D2 one node serially sectioned Into five pieces D3 tan tubular tissue submitted entirely D4 fibrous tissue for microscopicnodes Specimen E, received in formalin labeled with the patlent's name and designated "left obturator lymph nodes", is fragmented adipose tissue, 5.5 x 4.0 x 1.2 cm. There are three possible lymph nodes, 0.5 cm to 3.2 x 1.0 x 0.7 cm. The nodes are submitted entirely as follows:. Section key: E1 two whole nodes E2-E3 one node serially sectioned Into eight pieces Specimen F, received In formalin labeled with the patient's name and designated "left common iliac lymph nodes", is 4.0 x 2.5 x 1.0 cm of fragmented adipose tissue. There are three possible nodes, 0.6 cm to 2.0 cm. The nodes are submitted antirely as follows:. Section key: F1 two whole nodes F2 one node serially sectloned into five pieces F3 fibrous tissue for microscopic node Specimen G, received in formalin iabeled with the patient's nane and designated "preaortic lymph nodes", is fragmented fibrofatty tissue with two staples. There is a 0.2 cm tan node adjacent to one of the staples. The specimen is submitted entirely as follows: Section key: G1 one lymph node G2 fibrous tissue for microscopic nodes Specimen H, received in formalin labeled with the patient's name and designated "right common iliac lymph nodes" is fragmented adipose tissue, 4.0 x 2.5 x 0.6 cm. There is one 0.3 cm tan node. Representative sections are submitted as follows: H1 - one node  H2-H3 - fibrous tissue for microscopic nodes Specimen I, received in formalin labeled with the patlent's name and designated "precaval and paracaval lymph nodes" is fragmented adipose tissue, 4.0 x 3.5 x 1.2 cm. There are seven possible nodes, 0.3 cm to 1.2 cm. The specimen is submitted entirely as follows: 11 - five whole nodes 12 - two whole nodes Specimen J, received in formalin labeled with the patient's name and designated "presacral lymph nodes" is fragmented adipose tissue, 3.2 x 2.4 x 1.1 cm. There are three possible lymph nodes, 0.2 cm to 1.2 cm. The nodes and representative fibrous tissue are submitted as follows: J1 - two whole nodes J2 - one node bisected  J3 - fibrous tissue for microscoplc nodes Specimen K, received in formalin labeled with the patient's name and designated "right internal and external iliac lymph nodes" is fragmented adipose tissue, 3.0 x 3.0 x 0.8 cm. There are two lymph nodes, 0.3 cm and 1.9 cm. The nodes Page 7 of 11
+
+--- Page 8 ---
+are submitted entirely as follows:. K1 - one whole node K2 - one node serially sectioned into five pieces Specimen L, received in formalin labeled with the patlent's name and designated. "right obturator lymph nodes" is fragmented adipose tissue, 4.5 x 3.0 x 1.1 cm.. There are three possible nodes, 0.2 cm, 0.5 cm, and 5.0 x 1.2 x 1.0 cm. The nodes are submitted entirely as follows: L1 - two whole nodes L2-L3 - one node serially sectioned into nine pieces Specimen M: Type ot speclmen: Urinary bladder, ureter stumps, prostate and seminal vesicies The patient's name and case number on the specimen container match the accompanying paperwork and cassettes. Procedure: Radical cystectomy and prostatectomy Fixative: Formalin Dimensions: Bladder - 6.0 cm - superior to Inferior x 7.5 cm - medial to lateral x 3.5 cm - anterior to posterior Right ureter - 1.6 cm in length, 0.4 cm in diameter Left ureter - 1.3 cm in length, 0.4 cm in diameter. Prostate, 3.1 cm - apex to base, 3.8 cm - right to ieft x 3.0 cm - anterior to posterior Description of findings: Tumor: There is a tan, fluffy, lobulated tumor in the right lateral wall, 2.1 x 1.1 cm. The tumor extends through the mucosa into the muscie and is greater than 1.0 cm from the inked posterlor adipose tissue. Involvement of Important adjacencies: None Unlnvolved mucosa: The mucosa in the left biadder is edematous.. Prostate, seminal vesicles and vasa deferentia: The prostate is serially sectioned apex to base into six slabs. The seminal vesicles are present. In slabs 3, 4 and 5, there is a firm nodule, 1.6 x 1.5 x 1.0 cm. This nodule has a weil-detined smooth border. It does not appear to cross the midline into the right lobe. Ink code: Bladder anterior - blue, bladder posterior - orange, right prostate - orange, left prostate - blue Sectlon key: M1 - right ureteral orifice to ureter edge  M2 - left ureteral orifice to ureter edge M3, M4 - bladder neck, green ink at edge of tumor for orientation. M5-M12 - tumor submitted entirely from the right wall, superior to Inferior M13 - mucosa, right dome  M14 - mucosa, anterlor wall. M15 - mucosa, left dome. M16, M17 - mucosa, left lateral wall M18 - mucosa, posterior wall M19 - slab 1, prostate, right apex, serially sectioned M20 - slab 2, left M21 - slab 4, right posterior. M22 - slab 5, right posterior M23 - slab 6, right posterior M24 - slab 6, right seminal vesicle, right seminal vesicle, prostatic interface M25 - slab 1, left apex, serially sectloned M26 - slab 2, left plus a trimming plece M27 - slab 3, left M28 - slab 4, left anterior M29 - slab 4, left posterior  M30 - slab 5, left anterior M31 - slab 5, left posterior Page 8 of 1!
+
+--- Page 9 ---
+M32 - slab 6, left posterior with seminal vesicle prostatlc interface ( Specimen N, received in formalin labeled with the patlent's name and designated "appendix" is a vermiform appendix with attached mesoappendix. The appendix is. 7.0 cm in length and 0.6 cm in diameter. The mesoappendix is 6.5 x 2.5 x 1.2 cm. The serosa is tan, smooth, and glistening. The cut surface of the appendix shows a 0.1 cm thick wall. the surface shows diffuse infiltrating adipose tissue extending from approximately 1.0 cm from the proximal margin to the. distal tip. Representative sections are submitted as follows: N1 cross sections, proximal margin inked oranne distal tip  N2 representative cross sections. Specimen O, received in formalin labeied with the patient's name and designated "!eft dlstal ureter margin" is a strip of mucosa, 1.5 cm in length and 0.7 cm in diameter. There is a Prolene suture at one end of the strip of mucosa. This : end of the specimen is inked grange. The specimen is bisected and submitted entirely as O1. Specimen P, received in formalin labeled with the patient's name and designated "right distal ureter' is a'roughly square portion of mucosa, 0.7 x 0.7 cm. There is a black silk suture on one side. The sutured side is inked orange. The specimen is bisected and submitted entlrely as P1. 1 Microscopic Description The stain quality is acceptable.. A-P. The microscopic findlngs are reflected in the diagnosis rendered. Intraoperative Diagnosis Time in: Time out: A1-FS. Right ureter: "Negative for tumor or high-grade dysplasia." B1-FS. Left ureter: "Negative for tumor or high-grade dysplasia." Reported to ***Flectrnnicall Sinned Out By Results Pathology Report - Scan on. : Bladder Cancer Recurrence Score Pathology Report - Scan on 1. Resuit History : Intraoperative Consultation Report BIOPSY QR SURGICAL SPECIMEN . Order Result History Report.. Coilection information Specimen Source Date and Time Other Accession # Lab Information Page 9 of 11
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diff --git a/output/text/fdcb5de8-16c7-430e-adae-de2112936a8e.txt b/output/text/fdcb5de8-16c7-430e-adae-de2112936a8e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d367512e89de87fba42c05bb3e2ded1c21efa613
--- /dev/null
+++ b/output/text/fdcb5de8-16c7-430e-adae-de2112936a8e.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:A07E7AF1-55EA-4EA1-A5DA-A54E17771CA9 TCGA-C5-A7UI-01A-PR Redacted SUrGiCAL PAThOLOgy REPORt IcD-o-3 * Consult Report * wq NoS 867zJ3 Site @ s3.9 FINAL  9/z e|13  Patient Name Address: Service: Accession #: Location: Taken: Gender. MRN : DOB: Age: Received: Hospital #: Accessioned Patient Type: Reported: Physician(s):  M.D DIAGNOSIS UTERUS, CERVIX, BiOPSY  - INVASIVE NON-KERATINIZING SQUAMOUS CELL CARCINOMA UTeruS, endoceRViX, CUreTTAge (B) - NO EVIDENCE OF MALIGNANCY By thls signature, I atest that the above diagnosis is based upon my personal. exanination of the slides(and/or otherimaterial indicated in the diagnosis).. M.D ***Report Electronically Roviewed and Signed Out B. M.D... Microscopic Description and Comment:. Microscopic examination substantiates the above cited diagnosis. History: M.D. The patient is a  year old woman with abnormal Pap smear. Operative procedure: Cervical biopsy and endocervical curettage. Materials Received: Received are two slides labeled. IA recut. B), accompanied by a corresponding pathology report. The materia! originates fromg  Physician Copy -
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diff --git a/output/text/fdec252f-cc27-424c-bf81-c4eaab518062.txt b/output/text/fdec252f-cc27-424c-bf81-c4eaab518062.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d29520a2888d0cc6bef51b415a32c0cd726f032f
--- /dev/null
+++ b/output/text/fdec252f-cc27-424c-bf81-c4eaab518062.txt
@@ -0,0 +1,15 @@
+
+--- Page 1 ---
+RUN DATE: PAGE 1 RUN TIME: Specimen Inquiry RUN USER: User : Lab Database: PATIENT : ACCT #: AGE/SX: ROOM: REG: DOB: BED: DIS: REG DR: STATUS : SPEC #: RECD : STATUS : COLL: TIME IN FORMALIN: 3:49 hrs. CLINICAL INFORMATION:S Pre-Op Diagnosis: Colon obstruction Remarks: zeD-o -3 Specimen(s): Colon (right) 8/40/3 Nos coLeLsuomr C/8.0 Site. Cecenoliry esln MICROSCOPIC DIAGNOSIS w o/3|3 RIGHT COLON WITH ATTACHED TERMINAL ILEUM AND APPENDIX. RIGHT HEMICOLECTOMY:S MODERATELY DIFFERENTIATED ADENOCARCINOMA OF THE ASCENDING COLON CARCINOMA MEASURES 4.5 CM IN GREATEST DIMENSION AND EXTENDS THROUGH THE BOWELS WALL INTO THE SUBSEROSAL FAT AND FOCALLY EXTENDS TO THE VISCERAL PERITONEALS SURFACE (pT4a) LYMPH-VASCULAR INVASION IDENTIFIED SURGICAL MARGINS OF RESECTION FREE OF TUMOR WITH THE CLOSEST SURGICAL MARGINS RADIAL MARGIN 5 CM THREE DISCONTINUOUS TUMOR DEPOSITS IN SUBSEROSAL TISSUE METASTATIC ADENOCARCINOMA IN 4 OF 33 SUBSEROSAL LYMPH NODES WITH FOCAL, EXTRACAPSULAR EXTENSION SEE COMMENT FOR SURGICAL PATHOLOGY CANCER CASE SUMMARY CHECKLIST  UUID:53BA96AA-B755-460C-83CF-ED5BCCD031F6 TCGA-NH-A6GA-01A-PR Redacted COMMENT(S) SURGICAL PATHOLOGY CANCER CASE SUMMARY - CAP APPROVED Specimen: Terminal ileum, cecum. appendix, ascanding colon. Procedure: Right hemicolectomy. Tumor Site: Right (ascending) colon Tumor Size: 4.5 cm in greatest dimension Macroscopic Tumor Perforation: Not identified HIstologic Type: Adenocarcinoma Histologic Grade: Low-grade Microscopic Tumor Extension: Tumor penetrates to the surface of the visceral peritoneum (serosa) - focal Margins: Distance of invasive carcinoma from closest margin: 5. cm: Radial Proximal: Uninvolved by invasive carcinoma Distal: Uninvolved by invasive carcinoma Circumferential: Uninvolved by invasive carcinoma. Treatment Effect: No prior treatment. Lymph-Vascular: Present ** CONTINUED ON NEXT PAGE **
+
+--- Page 2 ---
+PAGE 2 RUN DATE: RUN TIME: Specimen Inquiry RUN USER: User : PATIENT: (Continued) SPEC #: cOmment(S) (Continued) Perineural Invasion: Not identified. Tumor Deposits: Present (number of deposits: 3) Pathologic Staging: Primary Tumor: pT4a Regional Lymph Nodes: pN2a Number examined: 33 Number involved: 4 Distant Metastasis: Not applicable GROSS DESCRIPTION: The specimen in formalin is right colon with attached terminal ileum and appondix. right hemicolectomy. The colon measures 25 cm in length by 3 cm in diameter. the small bowel measures 7.5 cm in length by 2 cm in diameter. and the appandix measures 10 cm in length by 1 cm in diameter. The closest radial margin is 5 cm. 3.5 cm distal to the ileocecal valvo there is a nearly circumferential ulcerating partially obstructing mass measuring 3 cm in length by 4.5 cm in width. At the distal end of this there is an associated polyp resection.  Cut section through the ulcerated mass reveals hard pinkish-tan tissue infiltrating through the wall into the overlying subserosa. The remainder of the mucosa throughout the colon and small bowel appears normal. There is one grossly enlarged subserosal lymph node measuring up to 3 cm in diameter containing hard white tissue with central necrosis which is soft and pasty. Other lymph nodes vary from small and rubbery to slightly onlarged. There is one slightly enlarged firm lymph node submitted separate from the intact specimen. Sections are submitted as follows: 1 proximal terminal ileum margin of resection 2 distal colon margin of resection 3 appendix 4-7 mass in colon grossly enlarged lymph node and separately submitted lymph node 8 9-14 - remainder of subserosal lymph nodes A portion of the colon mass has been processed with tumor tissue banking protocol. MICROSCOPIC DESCRIPTION: The slides are examined and ovaluated. INTRAOPERATIVE CONSULTATION: Specimen processed for tissue banking per protocol. ** CONTINUED ON NEXT PAGE **
+
+--- Page 3 ---
+PAGE 3 RUN DATE: Specimen Inquiry RUN TIME: User: Lab Database: RUN USER: (Continued) PATIENT SPEC #: PHOTO DOCUMENTATION Image Image Image Image Image Image Image Signed (signature on file)- ** END OF REPORT **
+
+--- Page 4 ---
+RUN DATE: PAGE 1 RUN TIME: Specimen Inquiry RUN USER: User: Lab Database: PATIENT ACCT #: AGE/SX : ROOM : REG : REG DR: DOB: BED: DIS: STATUS: SPEC #: RECD: STATUS : COLL : TIME IN FORMALIN: hrs. CLINICAL INFORMATION: Pre-Op Diagnosis: Colon CA: liver mass: Ro metastatic Remarks: Specimen(s) : Fine needle aspirate cytology liver MICROSCOPIC DIAGNOSIS FINE NEEDLE ASPIRATE CYTOLOGY LIVER: MALIGNANT TUMOR CELLS PRESENT CONSISTENT WITH METASTATIC ADENOCARCINOMA OF COLONIC PRIMARY ORIGIN GROSS DESCRIPTION: The specimen is obtained by under cT guidance.  Three passes are made from which three smears are stained with Pap stain and one smear is stained with Diff-Quik stain for immediate assessment for specimen adequacy. Needle rinses are combined for coll block. INITIAL IMPRESSION: IMMEDIATE STUDY FINE NEEDLE ASPIRATE: MALIGNANT TUMOR CELLS PRESENT. ADEQUATE FOR EVALUATION. TELEPHONED REPORT TO Signed ..(signature on file). ** END OF REPORT **
+
+--- Page 5 ---
+RUN DATE : RUN TIME: Specimen Inquiry. PAGE 1 RUN USER: User : Lab Database: PATIENT: ACCT U #: AGE/SX: ROOM: REG DR: REG: DOB: BED: DIS: STATUS : SPEC #: RECD : STATUS : COLL : TIME IN FORMALIN: 6:3U hrs. CLINICAL INFORMATION : Pre-Op Diagnosis: R/O metastatic colon CA. Remarks: Spscimen(s): CT-guided needle biopsy liver. MICROSCOPIC DIAGNOSIS CT-GUIDED NEEDLE BIOPSY. LIVER: METASTATIC ADENOCARCINOMA CONSISTENT WITH COLONIC PRIMARY GROSS DESCRIPTION: The specimen in formalin in one container is several core biopsy fragments of tan tissue which in aggregate measure 10 x 2 x 1 mm. totally submitted as block 1. Signed (signature on file). ** END OF REPORT  2315
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diff --git a/output/text/fe08635e-a318-4b2a-ba18-7113a9146647.txt b/output/text/fe08635e-a318-4b2a-ba18-7113a9146647.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9bbea72f61c36b35bb0c0bae3ae8de8d16edf03b
--- /dev/null
+++ b/output/text/fe08635e-a318-4b2a-ba18-7113a9146647.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+TCGA-A6-3807 SPECIMEN A. Sigmoid colon. B. Left tube and ovary C. Right tube and ovary D. Appendix CLINICAL NOTES PRE-OP DIAGNOSIS: Sigmoid colon. GROSS DESCRIPTION A. Received fresh, subseguently fixed in formalin, labeled. "sigmoid colon" is a 13.5 cm. long portion of colon which. is opened at both ends. The ends are arbitrarily inked blue and black. The serosa is pink-tan smooth glistening and shows a scabrous surface located 5 cm. from the black-inked margins. This scabrous focus is inked blue. The specimen is opened to show a pink-tan smooth glistening mucosa with normal to abundant folds having an average circumference of 4 cm. There is an ulcerated lesion located 3 cm. from the black-inked end which is circumferential and is 5.5 x 4.5 x 1.2 cm. There is also a pedunculated polyp measuring 1.5 cm. located 6 cm. from the blue-inked end. This appears to show no additional invasion grossly identified. The large ulcerated lesion shows invasion through the muscularis propria and possibly into the fat coming within 7 cm. of the radial margin. Subjacent lymph nodes, however, are firm and indurated. The remainder of the mucosa is pink-tan with normal to abundant folds. Representative sections of the specimen are submitted as follows:. BLOCK SUMMARY: 1 - representative luminal margins; 2-4 - representative section of tumor, normal and fat; 5 - representative radial margins; 6 - entire pedunculated polyp with base; 7 - 9. possible lymph nodes; 8 - 9 possible lymph nodes; 9 - 9 possible lymph nodes; 10 - 9 possible lymph nodes; 11 - 2 possible lymph nodes; 12 - 1 possible lymph node bisected; 13 - 1 possible lymph
+
+--- Page 2 ---
+GROSS DESCRIPTION node sectioned; 14 and 15 . representative sections of largest mottled lymph node. Rs-15. B. Received fresh, subsequently fixed in formalin, labeled "left tube and ovary" is a 3.3 x 3.0 x 2.5 cm. cystic and cerebriform ovary. This is attached to a 4.0 x 0.5 cm. fimbriated fallopian tube having a 2.0 cm. paratubal cyst. The cyst is partially filled with clear fluid and shows no papillary excresences present. The ovarian cyst is 1.2 cm. with no papillary excresences present. No other discrete gross lesions are identified. Representative sections of the specimen are submitted four cassettes. RS-4. C. Received fresh, subsequently fixed in formalin, labeled "right tube and ovary" is a 2.5 x 2.2 x 1.7 cm. pink tan cerebriform ovary which has a fimbriated fallopian tube measuring 4.0 x 0.7 cm. The specimen has a paratubal cyst measuring 1.2 x 0.7 cm. It is partially filled with clear fluid, shows no papillary excresences present. The ovary is sectioned to show a white tan mottled cut surface with no discrete gross lesions identified.. Representative sections of the specimen are submitted four cassettes. RS-4. D. Received in formalin, labeled "appendix" is a 7.2 x 0.5 cm. appendix which is partially covered with pink-tan smooth glistening serosa and yellow lobular fat. The specimen is. sectioned to show an intact wall averaging 0.3 cm. No other. discrete gross lesions are identified. Representative sections of the specimen are submitted in one cassette. Rs-1. Proximal end is inked blue.
+
+--- Page 3 ---
+MICROSCOPIC DESCRIPTION Histologic type: Adenocarcinoma Histologic grade: Moderately-differentiated Primary tumor (pT3): Carcinoma is into and through the muscularis propria, into the subserosal fat. Proximal/distal/radial margins: Negative.. Vascular invasion: Present. Regional lymph nodes (pN): Metastatic carcinoma in 5 of 24 lymph nodes (5/24). Non-lymph node pericolonic tumor: Not identified. Other findings: Tubular adenoma; unremarkable appendix and. fallopian tubes; bilateral adnexal cysts and ovarian follicular. cysts. 5, 3x2, 1 DIAGNOSIS A. Colon, sigmoid, segmental resection:. Adenocarcinoma, moderately-differentiated, extending into and. through the muscularis propria (pT3).. Margins of excision negative. Metastatic carcinoma in 5 of 24 lymph nodes (5/24).. B. Ovary and fallopian tube, left, salpingo-oophorectomy:. Simple adnexal cyst. Corpus luteal cyst. Unremarkable fallopian tube. C. Ovary and fallopian tube, right, salpingo-oophorectomy: Simple adnexal cyst. Ovarian follicular cyst Unremarkable fallopian tube. D. Appendix, incidental appendectomy: No specific pathologic abnormality. ... End Of Report --.
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diff --git a/output/text/fe23604d-173d-4f0d-ae7b-e4133a2295a7.txt b/output/text/fe23604d-173d-4f0d-ae7b-e4133a2295a7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..88cc037cd70cb18332811b790b1b3f38ad44cc31
--- /dev/null
+++ b/output/text/fe23604d-173d-4f0d-ae7b-e4133a2295a7.txt
@@ -0,0 +1,21 @@
+
+--- Page 1 ---
+Name: Case #: DOB: (Age: Collected: Gender: Received: MRN: Reported: Location: Copy To: Physiclan: Pathologic Interpretation: 1Cs-0-3 Cascinora, mfiltnating lobuler, Nos 8520/3 A. SENTINEL NODE NO.1 AXILLA CONTENT - No malignancy seen in one lymph node (0/1). Sihr buast, Nos Cso.9 H/gf - Immunohistochemistry for keratin to follow. B. Right Breast (ShOrt StItCh SuperiOr LOng Stitch LAteraL): - Invasive lobular carcinoma, intermediate nuclear grade, with formation of two dominant tumoral masses, 4 0 cm and 1.0 cm. - The tumor invades the dermal skin. - Lymphovascular spaces invasion is identified.. - Specimen margin is negative for tumor. - Metastatic carcinoma to two of eight lymph nodes (/2/8) C. SENTInEL NODE NO. 2 AXILLA COUNT - No malignancy seen in one lymph node (0/1). - Immunohistochemistry for keratin to follow.. Tumor Summary: UUID:D4194F52-3E15-4105-9A1A-1326CF128BF8 Speclmen: Redacted TCGA-EW-A1IW-01A-PR . Total breast Procedure: - Total mastectomy Lymph Node Sampling: - Sentinel lymph node - Axillary dissection Specimen Integrity: - Single intact specimen Specimen Size: - Greatest dimension: 21 cm * Additional dimension: 16 x 4 cm. Laterality: - Right Tumor Slte: - Lower outer quadrant - Upper inner quadrant. - Lower inner quadrant Tumor Size: - Greatest dimension of largest focus of invasion over 0.1 cm: 4 cm. - Additional dimensions: 1 x 1 cm. Tumor Focality: - Multiple focus of invasive carcinoma.. Macroscopic and Microscoplc Extent of tumor: - Skin: Satellite skin foci of invasive carcinoma are present. Lobular Carcinoma IN Situ (LCiS): - Present Histologic Type: - Invasive lobular carcinoma Histologic Grade: - Overall Grade: Grade 2 Margins: - Margins uninvolved by invasive carcinoma.. Lymph-Vascular Invasion: - Present Dermal Lymph-Vascular Invasion:
+
+--- Page 2 ---
+SURGICAL PATHOL Report -- Not identified. Lymph Nodes: - Number of sentinel lymph nodes examlned: 2. - Total number of lymph nodes examined (sentinel and Nonsentinel): 10. - Number of lymph nodes with macrometastases (>0.2 cm): 2 Extranodal Extenslon: - Not identified Method of Evaluation of Sentinel Lymph Nodes: - Hematoxylin and eosin (H&E, one level) - Immunohistochemistry. Ancillary Studies: Estrogen Receptor: - Performed on another specimen: Results: Immunoreactive tumor cells present (1%). Progesterone Receptor: - Performed on another specimen: Results: Immunoreactive tumor cells present (1%) HER2/neu - Performed on another specimen: Results: Equivocal (Score 2+) CISH for HER2/Neu: - Performed on another specimen: Results: Not amplified (HER2 gene copy <4.0 or ratio1.8) TNM Descriptors: - m (multiple foci of invasive carcinoma) Primary Tumor (invasive Carcinoma) (pT).. - pT4b Reglonal Lymph Nodes (pN): - pN1a Distant Metastasis (M): - Not applicable Pathologic Staglng (pTNM): mpT3, N1a, M-not applicable NOTE: Some inmwrohisiochemical anribodies are c 1D5-ER, PgR 636-PR, A485-HER2, H-11-EGFR. All imm th for pathologist as posirive or negatiye. As the attending pathologist, I atiest that I: (i) Examined the relevdnt preparation(s). for the specimen(s): and (ii) Rendered the diagnosis(es) ***Electronically Signed Out By*** Procedures/Addenda Addendum Date Ordered: Status: Signed Out Date Complete: Date Reported: Addendum Diagnosis A SENTINEL NODE # 1 AXILLA CONTENT - Immunohistochemistry for keratin stain is negative for metastatic carcinoma to the ymph node. C. SENTINEL NODE # 2 AXILLA COUNT - Immunohistochemistry for keratin stain is negative for metastatic carcinoma to the lymph node. Page 2 of 3
+
+--- Page 3 ---
+SURGICAL PATHOL Report Intraoperatlve Consultation A. Sentinel node # 1 axilla content @ frozen section: Touch prep: Negative for metastatic carcinoma. C. Sentinel node # 2 Axilla count ind Touch prep: Negative for metastatic carcinoma. Clinical History: Lobular carcinomae Operation Performed Right breast total mastectomy; Possible axillary node dissection; Sentinel node biopsy. Pre Qperative Diagnosis: Breast cancer Specimen(s) Recelved: A: Sentinel node # 1 axilla content : B: Right breast (short stitch superior long stitch lateral) C: Sentinel node # 2 Axilla count Gross Description.. A. Received fresh is an ovoid pale tan tissue fragment, 1 x 1 x 0.2 cm. Bisected and submitted in toto in one ca$sette for frozen section.. Received is a right mastectomy specimen with axillary tail, 21 x 16 x 4 cm. The specimen is oriented with shqrt suture- B superior margin and long suture-lateral margin. At the anterior aspect, there is a segment of skin 10 x 5.5 x 0|5 cm with areola and nipple. The nipple is depressed. There is an ill defined tumor mass, 4 x 3 x 1 cm, located at both Ipwer inferior quadrants (outer and inner). There is a metallic cilp. At the upper inner quadrant, there is a second tumor mass, 1 x 1 x 0.5 cm present, close to the anterior margin. The rest of the breast presante fow hreast stroma and abundant yellow. adipose tissue. Representative portion of tissue was taken for the : Ten possible lymph nodes are grossly identified and present at the axillary tail. Representative sections are submitted in nineteen cassettes as follows: Nipple 2  Deep margin 3&4 Tumor, lower outer quadrant. 5&6 Tumor, lower inner quadrant 7 Middle line tumor. 8  Second mass, upper inner quadrant close to anterior margin 9 Upper outer quadrant 10&11 One entire lymph node, per block 12-19 One lymph node bisected, per block c. Received is an ovoid pale tan tissue fragment, 1.2 x 1 x 0.5 cm. Bisected and submitted in toto in one cassetle for frozen section. Page 3 ot 3
+
+--- Page 4 ---
+Name: Case #: DOB: Collected: Gender: Received: MRN: Reported: Location: Copy To: Physiclan: Pathologic Interpretation: AmmenDment tO pathOlOgic tumOr StagIng AnD ResuLts Of heR2 8y CiSh (. A. SENTINEL NODE NO.1 AXILLA CONTENT - No malignancy seen in one lymph node (0/1) - Immunohistochemistry for keratin to follow. B. Right sreast (Short stitch superior long stitch Lateral): - Invasive lobular carcinoma, intermediate nuclear grade, with formation of two dominant tumoral masses, 4.0 cm and 1.0 cm. -The tumor invades the dermal skin. - Lymphovascular spaces invasion is identified.. - Specimen margin is negative for tumor. - Metastatic carcinoma to two of eight lymph nodes (/2/8) C. SENTINEL NODE NO. 2 AXILLA COUNT 605 FS: - No malignancy seen in one lymph node (0/1). - Immunohistochemistry for keratin to follow. icd-o-3 Tumor Summary: carcinoma,inF JHoting Specimen: Inbulgr, NOs 5 8520f3  Total breast Procedure: - Total mastectomy Sidc:br<gst,N0s c50,9 Lymph Node Sampling: Sj3iji z - Sentinel lymph node rD - Axillary dissection Specimen Integrity: - Single intact specimen. Specimen Size: - Greatest dimension: 21 cm  Additional dimension: 16 x 4 cm. Laterality: - Right Tumor Site: - Lower outer quadrant - Upper inner quadrant - Lower inner quadrant Tumor Size: - Greatest dimension of largest focus of invasion over 0.1 cm: 4 cm. - Additional dimensions: 1 x 1 cm. Tumor Focallty: - Multiple focus of invasive carcinoma. Macroscopic and Mlcroscopic Extent of tumor:. - Skin: Satellite skin foci of invasive carcinoma are present Lobular Carclnoma IN Situ (LCIS): - Present Histologlc Type: - Invasive lobular carcinoma Histologic Grade: - Overall Grade: Grade 2 Margins: - Margins uninvolved by invasive carcinoma..
+
+--- Page 5 ---
+Lymph-Vascular Invasion: - Present Dermal Lymph-Vascular Invaslon: - Not identified. Lymph Nodes: - Number of sentinel lymph nodes examined: 2. - Total number of lymph nodes examined (sentinel and Nonsentinel): 10. - Number of lymph nodes with macrometastases (>0.2 cn): 2 Extranodal Extenslon: Not identified Method of Evaluation of Sentinel Lymph Nodes: - Hematoxylin and eosin (H&E, one level) - Immunohistochemistry. Ancillary Studles: Estrogen Receptor: - Performed on another specimen: Results: Immunoreactive tumor cells present (1%). Progesterone Receptor: - Performed on another speclmen: Results: Immunoreactive tumor cells present (1%) HER2/neu - Performed on another specimen: Results: Equivocal (Score 2+) CISH for HER2/Neu: - Performed on another specimen: Results: Amplified (HER2 gene copy <4.0 or ratio <1.8) (amended. TNM Descriptors: - m (multiple focl of invasive carcinoma). Primary Tumor (invasive Carcinoma) (pT). - pT4b Regianal Lymph Nodes (pN): - pN1a Distant Metastasis (M): - Not applicable Pathologic Staging (pTNM): mpT4b, N1a, M-not applicable (amended SOIE: Some inauahisocemisol onibonts gs suatyk pxic nugeus (Ast) unutd hy our hhxatory: These ASRs are choncally nful uhars taut do mot ruuie t1A aprnul. Heu cloxs are aud: 15ERPgR636R A35H2 t.Rinhiolun e d ih formalor moleck ix purfin mhietcctonis b e results are rem' bya hgpoe. As the attending pahologist,I ttest that I (i Examined the relevan preparation(s) for the specimen(s):and (ii) Rendered the diagnosis(es) ***Electronically Signed Out By**** Amendments Amended: Reason: Revise/Update Tumor Staging Previous Signout Date: Procedures/Addenda Addendum Date Ordered: Status: Signed Out Date Complete: Date Reported: Page 2 of 1
+
+--- Page 6 ---
+Addendum Diagnosis. A. SENTINEL NODE # 1 AXILLA CONTENT - Immunohistochemistry for keratin stain is negative for metastatic carcinoma to the lymph node.. C. SENTINEL NODE # 2 AXILLA COUNT - Immunohistochemistry for keratin stain is negative for metastatic carcinoma to the lymph node.. Intraoperative Consultation A. Sentinel node # 1 axilla content ? frozen section: Touch prep: Negative for metastatic carcinoma.. C. Sentinel nade # 2 Axilla count and Touch prep: Negative for metastatic carcinoma. Clinical History: Lobular carcinoma Operation Performed Right breast total mastectomy; Possible axillary node dissection; Sentinel node biopsy. Pre Operative Diagnosis: Breast cancer Specimen(s) Recelved: A: Sentinel node # 1 axilla content B: Right breast (short stitch superior ong stitch lateral) C: Sentinel node # 2 Axilla count Gross Description: A. Received fresh is an ovoid pale tan tissue fragment, 1 x 1 x 0.2 cm. Bisected and submitted in toto in ona cassette for frozen section. B, Received is a right mastectomy specimen with axillary tail, 21 x 16 x 4 cm. The specimen is oriented with short suture-  superior margin and long suture-lateral margin. At the anterior aspect, there is a segment of skin 10 x 5.5 x 0.5 cm with areola and nipple. The nipple is depressed. There is an ill delined tumor mass, 4 x 3 x 1 cm, located at both lower inferior quadrants (outer and inner). There is a metallic clip. At the upper inner quadrant, there is a second tumor mass, 1 x 1 x 0.5 cm present, close to the anterior margin. The rest of the breast presents few hreast stroma and abundant yellow adipose tissue. Representative portion of tissue was taken for the. Ten possible lymph nodes are grossly identified and present at the axillary tail. Representative sections are submitted in nineteen cassettes as follows: Nipple 2 Deep margin 3&4 Tumor, lower outer quadrant 5&6 Tumor, lower inner quadrant 7 Middle line tumor 8 Second mass, upper inner quadrant close to anterior margin 9 Upper outer quadrant 10&11 One entire lymph node, per block 12-19 One lymph node bisected, per block C.  Received is an ovoid pale tan tissue fragment, 1.2 x 1 x 0.5 cm. Bisected and submitted in toto in one cassette for frozen Page 3 of 4
+
+--- Page 7 ---
+section. Page 4 of t
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diff --git a/output/text/fe3a65b4-15b9-4bb4-a64e-6931372e7968.txt b/output/text/fe3a65b4-15b9-4bb4-a64e-6931372e7968.txt
new file mode 100644
index 0000000000000000000000000000000000000000..470622ce2ff837d9415ce40b16cddeb36d34eff7
--- /dev/null
+++ b/output/text/fe3a65b4-15b9-4bb4-a64e-6931372e7968.txt
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+
+--- Page 1 ---
+1d/of1o bw 1Cs-0-3 Carciiomn, hnfi1t^ntmy duct, N0s 85oof3 c50.9 Sr+e Codi: brLugt, NOs B1961 Final Diagnosis Breast, left, wide local excision: Infiltrating ductal carcinoma with mucinous features, Nottingham grade III (of III), forming a mass (1.9 x 1.0 x 0.9 cm) [AJCC pT1c]. Ductal carcinoma in situ, high nuclear grade, comprises approximately 5-25% of the tumor volume and extends beyond the main mass. Angiolymphatic invasion is absent. The non-neoplastic breast parenchyma shows proliferative fibrocystic changes. The medial margin, after multiple (3) separately submitted re-excisions, is positive for ductal carcinoma in situ. Breast, left, simple mastectomy: Microscopic residual ductal carcinoma in situ is identified in the region of the prior biopsy site in the upper inner quadrant. No residual invasive neoplasm identified. The skin, nipple, and deep surgical margin are free of neoplasm.. Sentinel lymph node, left axillary, sentinel biopsy: A single left axillary sentinel lymph node with blue dye is negative for metastatic carcinoma [AJCC pN0 (i-) (sn)]. Immunohistochemical cytokeratin stain was performed on the paraffin embedded sentinel lymph node tissue and confirms the H&E impression. Her-2/NEU has been ordered on paraffin-embedded tissue.. UUID:0BFF09DE-6F36-4F68-AC13-8BC16AA0DCBE TCGA-AR-A1AP-01A-PR Redacted
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diff --git a/output/text/fe40fd05-06d6-452b-b9ca-5a4fcc55be1f.txt b/output/text/fe40fd05-06d6-452b-b9ca-5a4fcc55be1f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..9fa455762ab090a4797814f7c549584317ce68fd
--- /dev/null
+++ b/output/text/fe40fd05-06d6-452b-b9ca-5a4fcc55be1f.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis (diagnoses): Colon resection sample with a moderately differentiated adenocarcinoma of the colorectal type, measuring a max of 3 cm in diameter, with infiltration of the pericolic fatty tissue, circumscribed penetration of the covering serosa and three local lymph node metastases. Tumor-free colon resection margins. Tumor-free mesenteric resection margin.. The tumor stage is: pT4, pN1 (3/21) pM1 (clinical liver and lung metastasis) L0, V0;. clinically G2
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diff --git a/output/text/fe9a11bb-689d-4c10-b9cc-6ed8d222b1e7.txt b/output/text/fe9a11bb-689d-4c10-b9cc-6ed8d222b1e7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..90de6dfdf85ec0d038dd30f52d4b826113630f04
--- /dev/null
+++ b/output/text/fe9a11bb-689d-4c10-b9cc-6ed8d222b1e7.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+DEPARTMENT OF PATHOLOCY (Metnplno'ire) S.t codi: bris. NUS C50.9 g523/3 SURGICAL PATHOLOCY REPORT Material j 0/>1 Imitt ed: I.ef' breast mass.. Clinical History: Clinical UUID: 39C689CA-F7BA-4554-BEC8-11F9C8142D9C Diagnosis: TCGA-B6-A0RU-01A-PR Reda Operating Patbalogy Number Surgeon: Gross Frami:ation: A.) "Left breast inass". Tissue sent for ER/pR. In formalin. A single irregular piece 1 of :irm! yellow and tan lobulated fibroadipose tissue which has been previously inked and 1 partially cross sectioned measuring 3.0  3.2 x 2.4 em. On cut surface there is a poorly cireumseribed firm gritty yellow-tan mass measuring approximately 2.7 x 2.4 x 1.8 cm. in greatest dimensions. This mass grossly extends to within the surgical margins. Ser.a.iy eross sectioned submitted in toto in Blocks I through 7.. Hc ROs" OpiC: The predur:.ir.ant component of the tumor is an infiltrating dueta!. Cure:l.sina witn alnost no tubule formation.. Extensive neerosis is seen in the. .:iitratirg component. A .r.inor component of comedo type intraductal carcinoma is seen u: the puripr.ery, making up .ess than a quarter of the tumor. Scattered through the tumor art. m..:ip.e foei of sarcomatous metaplasia characterized by myxoid stroma of high Cu..ularit: with rudimentary cartilaginous differentiaticn. Although small foci of tnis. r.u.apias.a are scattered trrougn the tumor, the epitheliat component of the tumor preco:inaies. Tumor extends to the margin of resection. The adjacent breast shows duet e.t..si. ...d papillary apocrine metaplasia.. DiAgNOSIS: "LEFT BREAST MASS": COMEDO INTRADUCTAL AND INFILTRATING DUCtAL CARCInOMA NUCLEAR GRADEPOORLy DIFFERENTIATED, HISTOLOGIC GRADE 3 OF 3 (2.7 CM. IN GREATEST DIAMETER), EXTENDING TO THE SURGICAL MARGIN. SARCOMATOUS METAPLASIA IS SEEN. SEE COMMENT. COMMENT: cvrewed  concurs.
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diff --git a/output/text/fe9c149d-d05e-4124-a5c3-cb791316fe61.txt b/output/text/fe9c149d-d05e-4124-a5c3-cb791316fe61.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1662798a7d9b4fe165b7dc738b44b6d3a3ca3c96
--- /dev/null
+++ b/output/text/fe9c149d-d05e-4124-a5c3-cb791316fe61.txt
@@ -0,0 +1,9 @@
+
+--- Page 1 ---
+Clinical Diagnosis & History: Pt with 10 cm right renal mass. Specimens Submitted: 1:Kidney,adrenal.peri-hilar node,right total nephrectomy 2:Lymph node, retropeitoneal; excision DIAGNOSIS: Kidney,adrenal, peri-hilar node, right total nephrectomy Tumor Type: Renal cell carcinoma-Chromophobe type Tumor Size: Greatestdiameter is 9.5 cm Local Invasion (for renal cortical types) Extends into renal pelvis Renal Vein Invasion: Not identified Surgical Margins: Free of tumor Non-Neoplastic Kidney: Unremarkable Adrenal Gland: Not involved Lymph Nodes: Free of tumor Number of nodes examined:2 Staging for renal cell carcinoma/oncocytoma pT2 Tumor >7.0cm in greatest dimension limited to the kidney 2.Lymph node,retropeitoneal; excision: LymphNodes: Not involved Number of nodes examined:13 Page1 of3
+
+--- Page 2 ---
+IATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL)AND THAT I HAVE REVIEWED AND APPROVED THIS REPORT. Special Studies: Result Special Stain Comment RECUT Gross Description: 1).The specimen is received fresh,labeled Right kidney,Perihilar node en bloc, and right adrenal  and consists of a total nephrectomy specimen with attached perinephric fat,renal vessels,ureter,adrenal gland and perihilar nodes weighing 1098 g post fixation.The kidney measures 16.3 x 12.5 x 7.9 cm.The attached ureter measures 9.4cm in length and 0.3 cm in diameter. The adrenal gland measures 5.3 x 1.4 x 1.1 cm. The ureter and vessel margins are identified, and appear pink tan-pink and grossly uninvolved by tumor. In the area of the hilum,few loosely attached possible lymph nodes are identified ranging in size from 0.4 to 1.4 cm in greatest dimension.The capsular surface of the kidney is pink-tan and smooth,and appears grossly uninterrupted. The specimen is bisected to reveal a well-circumscribed pseudoencapsulated red-tan focally hemorrhagic soft tumor mass measuring 9.5 x 8.9 x 7.8 cm,occupying the superior and mid pole of the kidney.The mass extends to but does not appear to grossly involve the renal pelvis.On cut section, roughly at the center of the tumor mass, an ill-defined paler white tan finely granular and slightly indurated area is identified measuring 5.5 x 2.5 cm in greatest dimension with ill-defined areas of focal hemorrhage also noted. The remainder of the mass is soft tan and focally hemorrhagic with liquefactive necrotic appearing areas noted. A thin rim of focally hemorrhagic pink-tan a firm possible renal parenchyma is identified partially surrounding the tumor Sections of theperi-nephric fatty tissue reveal an unremarkable cut surface.The ureter is opened to reveal pink-tan corrugated mucosa with no discrete abnormalities grossly noted. The inferior renal sinus is grossly unremarkable.On cut section, the adrenal gland is grossly unremarkable. At the inferior pole of the kidney,the cortical medullary junction is well delineated with a cortex measuring up to 1 cm.Further sectioning reveals a 0.8 cm smooth walled cyst at the inferior pole.The remaining renal parenchyma is pink brown and unremarkable.Representative sections of the specimen are submitted fo for permanent section, and photographs have been taken. Summary of sections: UM-ureteral margin shaved VM-vascular margins shaved HN-possible peri-hilar lymph nodes RST-representative sections TWC-tumor with capsule and perinephric fat NK- normal kidney NKC-normal kidney with cyst RP-renal pelvis A-representative adrenalgland RS-renal sinus 2).The specimen is received in formalin, labeled "retroperitoneal lymph nodes"and consists of multiple pink tan firm lymph nodes ranging from 0.4 to 2.5 cm in greatest dimension.All identified lymph nodes are submitted. Summary of sections LN--lymph nodes Summary of Sections: Part 1:Kidney,adrenal, peri-hilar node, right; total nephrectomy Page2of3
+
+--- Page 3 ---
+SURGICAL PATHOLOGY REPORT Block Sect.Site PCs 1 a 1 hn 1 1 1 nk 1 1 nkc 1 2 rp 2 1 rs 1 7 rst 7 1 twc 1 1 um 1 1 vm 1 Part 2: Lymph node,retropeitoneal;excision Block Sect.Site PCs 4 In 4 Page 3of3 END OFREPORT
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diff --git a/output/text/fe9f1768-fcd9-41c1-aec0-415dfd005054.txt b/output/text/fe9f1768-fcd9-41c1-aec0-415dfd005054.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1a3e4fec8b869790056cab9921a6d4b878fe5d1d
--- /dev/null
+++ b/output/text/fe9f1768-fcd9-41c1-aec0-415dfd005054.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+TCGA #: Sample ID #. Diagnosis: Right hemicolectomy preparation with tumor-free resection margins and displaying an ulcerated, moderately differentiated adenocarcinoma of the cecum, with some sections showing more relatively marked production of mucus, with infiltration of the perimuscular. fatty tissue and without local Iymph node metastases (G2, pT3 L0 V0 R0 pN0 0/22). Ics-0-3 adnocarcinvms, muciious, Nos 848o/3 Site: CecumC18.o hs 3/3/1 UUID:4E27D129-1AC8-4382-B77B-9F8545EFEBE1 TCGA-AA-A01G-01A-PR Redacted
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diff --git a/output/text/feb39be6-a5ec-421f-8231-3787298f14ad.txt b/output/text/feb39be6-a5ec-421f-8231-3787298f14ad.txt
new file mode 100644
index 0000000000000000000000000000000000000000..5a9fa7d4c97215c4df6ee5295bc5d0e7ee872585
--- /dev/null
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+--- Page 1 ---
+DIAGNOSIS: 1. Kidney, left, mass, #1 (excision): Renal cell carcinoma, papillary type I. 2. Kidney, left, mass, #2 (excision): Renal cell carcinoma, papillary type I. 3.  Kidney, left, mass, #3 (excision): Renal cell carcinoma, papillary type I. 4. Kidney, left, mass, #4 (excision): Renal cell carcinoma, papillary type I. 5. Kidney, left, mass, #5 (excision): Renal cell carcinoma, papillary type I; incipient lesions present. Kidney, left, mass, #6 (excision): Renal cell carcinoma, papillary type I. 7.  Kidney, left, mass, #7 (excision): Renal cell carcinoma, papillary type I. 8. Kidney, left, mass, #8 (excision): Renal cell carcinoma, papillary type I. 9. Kidney, left, mass, #9 (excision): Renal cell carcinoma, papillary type I. 10. Kidney, left, mass, #10 (excision): Renal cell carcinoma, papillary type I with spindle and clear cell differentiation. 11. Kidney, left, mass, #11 (excision): Renal cell carcinoma, papillary type I with spindle and clear cel differentiation. 12. Kidney, left, mass, #12 (excision): Renal cell carcinoma, papillary type I. 13. Kidney, left, mass, #13 (excision): Renal cell carcinoma, papillary type I with spindle cell differentiation. 14. Kidney, left, mass, #14 (excision): Renal cell carcinoma, papillary type I. Patient Identification
+
+--- Page 2 ---
+15. Kidney, left, mass, #15 (excision): Renal cell carcinoma, papillary type I. 16. Kidney, left, mass, #16 (excision): Renal cell carcinoma, papillary type I.. 17. Kidney, left, mass, #17 (excision): Renal cell carcinoma, papillary type I; incipient lesions present.. 18. Soft tissue, perinephric, left (excision): Fibroadipose tissue. CLINICAL INFORMATION: Allocate Order to Brief Clinical History: pt with. history of renal cell carcinoma with multiple left renal masses PROCEDURE: Partial nephrectomy.. SPECIMENS SUBMITTED: 1. KIDNEY, LEFT NEPHRECTOMY, TumOr #1 2. KIDNEY, LEFT NEPHRECTOMY, Tumor #2 3. KIDNEY, LEFT NEPHRECTOMY, Tumor#3 4. KIDNEY, LEFT NEPHRECTOMY, Tumor #4 5. KIDNEY, LEFT NEPHRECTOMY, Tumor #5 6. KIDNEY, LEFT NEPHRECTOMY, Tumor #6 7. KIDNEY, LEFT NEPHRECTOMY, Tumor#7 8. KIDNEY, LEFT NEPHRECTOMY, Tumor #8 9. KIDNEY, LEFT NEPHRECTOMY, Tumor #9 10. KIDNEY, LEFT NEPHRECTOMY, Tumor #10 11. KIDNEY, LEFT NEPHRECTOMY, Tumor#11 12. KIDNEY, LEFT NEPHRECTOMY, Tumor #12 13. KIDNEY, LEFT NEPHRECTOMY, Tumor #13 14. KIDNEY, LEFT NEPHRECTOMY, Tumor #14 15. KIDNEY, LEFT NEPHRECTOMY, Tumor #15 16. KIDNEY, LEFT NEPHRECTOMY, Tumor #16 17. KIDNEY, LEFT NEPHRECTOMY, Tumor #17 18. FAT, Perinephric GROSS DESCRIPTION: Received are 18 containers labeled with the patient's name, medical record. number, and further specified as follows: 1.' :"Tumor #1". The specimen consists of a yellow-tan nodule measuring 0.8 cm in greatest dimension, is bisected and submitted in toto in a white cassette labeled for permanent processing. 2."Tumor #2". The specimen consists of a red/tan soft tissue mass measuring 2.5 x 2.5 x 2 cm. Sectioning reveals a yellow-tan, solid cut surface. Approximately 50% of tissue is procured for the. Laboratory. The specimen received at the. is consistent with the above  description. Representative sections are submitted in. white cassettes labeled #2A-2C for permanent processing. Patient Identification.
+
+--- Page 3 ---
+3. "Tumor #3", is a tissue mass measuring 1.5 x 1.2 x 1 cm.. Sectioning reveals a yellow-tan, soft cut. surface with hemorrhagic foci. 50% is procured for the. Laboratory and the remaining tissue is sent to Surgical Pathology. The specimen received at the. is consistent with the above description, is sectioned and submitted in toto in white cassette labeledj #3A for permanent processing. 4. "Tumor #4". The specimen is a soft tissue fragment measuring 1 x 1 x 1 cm. Sectioning reveals a tan cut surface with a white/tan area in the center. Approximately 50% is procured for the Laboratory and the remaining tissue is sent to Surgical Pathology. The specimen received at the. is consistent with the above description, is sectioned and submitted in toto in a white cassette labeled #4A for permanent processing. 5. "Tumor #5". The specimen is a yellow-tan fragment of tissue measuring 1 x 0.5 x 0.3 cm, is collected by filtration, and submitted in toto in a white cassette labeled #5A for permanent processing. 6. "Tumor #6". The specimen is a yellow-tan nodule measuring 0.3 cm in greatest dimension, is collected by filtration, and submitted in toto in a white cassette labeled 7. "Tumor #7". The specimen is a yellow-tan fragment of tissue measuring 0.3 cm in greatest dimension, is collected by filtration, and submitted in toto in a white cassette labeled. #7A for permanent processing. 8. "Tumor #8'. The specimen is a yellow-tan nodule measuring 0.4 cm in greatest dimension, is collected by. filtration, and submitted in toto in an orange cassette labeled. #8A for permanent processing. 9. "Tumor #9'. The specimen is a yellow-tan nodule measuring 0.6 cm in greatest dimension and is submitted in toto in a white cassette labeled #9A for permanent processing. 10. "Tumor #10". The specimen is a corrugated nodule measuring 2 x 1 x 0.8 cm, is sectioned and submitted in toto in a white cassette labeled #10A for permanent processing. 11. "Tumor #11". The specimen is a fragment of soft tissue measuring 4 x 2.5 x 2.5 cm. Sectioning reveals a a yellow-tan cut surface. Approximately 50% is procured for the. Laboratory and the remaining tissue is sent to Surgical Pathology. The specimen received at the Laboratory of Pathology is consistent with the above description. Representative sections are submitted in white cassettes labeled #11A-#11D for permanent processing. 12. "Tumor #12". The specimen is a fragment of soft tissue measuring 1.3 x 1.2 x 1 cm. Sectioning reveals a tan cut surface with hemorrhagic foci, partially cystic with blood. Approximately 50% is procured for the and the remaining tissue is sent to Surgical Pathology. The specimen received at the. Laboratory of Pathology is consistent with the above description and is submitted in toto in a white cassette labeled #12A for permanent processing. Patient Identification
+
+--- Page 4 ---
+13. "Tumor #13". The specimen is a yellow-tan nodule measuring 0.8 cm in diameter. Sectioning reveals a. tan smooth cut surface. The specimen is submitted in toto in a white cassette labeled. #13A for permanent processing. 14. "Tumor #14". The specimen is a yellow-tan nodule measuring 0.7 cm in greatest dimension, is bivalved and submitted in toto in a white cassette labeled. #14A for permanent processing. 15. "Tumor #15". The specimen is a yellow-gray nodule measuring 0.7 cm in greatest dimension that appears to be sectioned, is submitted in toto in a white cassette labeled. 15A for permanent processing. 16. "Tumor #16".  The specimen is a yellow-tan fragment of tissue measuring 1 x 0.5 x 0.3 cm and is submitted in toto in a white cassette labeled. #16A for permanent processing. 17. "Tumor #17". The specimen is a mass measuring 5.5 x 5 x 4.5 cm. Sectioning reveals a yellow-tan solid cut surface with areas of hemorrhage. Approximately 50% is procured for the. and the remaining tissue is sent to Surgical Pathology. The specimen received at the Laboratory of Pathology is consistent with the above description. Representative sections are submitted in white cassettes labeled #17A-#17F for permanent processing. 18. "Perinephric fat". The specimen is an irregular fibrofatty fragment of tissue measuring 7.5 x 6.5 x 3 cm. Dissection reveals two areas of apparent fibrosis measuring 3 x 0.5 x 0.5 cm (#1) and 3 x 1 x 0.5 cm (#2). No lymph nodes are identified. Representative sections of fibrofatty tissue are submitted in white cassette labeled #18A for permanent processing. Area of firmness #1 is submitted in white. cassette labeled #18B-#18H for permanent processing. Area of firmness #2 is submitted in white cassettes labeled #18l-#18K for permanent processing. Procurement is carried out by No consultants
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diff --git a/output/text/fecbfb92-6c98-4091-936d-2a0884412dc7.txt b/output/text/fecbfb92-6c98-4091-936d-2a0884412dc7.txt
new file mode 100644
index 0000000000000000000000000000000000000000..30c79dfb726b53c58ed166ea75abc70d8a662573
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+
+--- Page 1 ---
+Requesting Doctor's Intormation: UUID: 3AE0E638-5907-4B56-9C55-E58D97B27AFF tcgA-Or-a55Q-01a-pr Redacted  m A HISTOPATHOLOGY FOR REVIEW T Site. LECF: H 0 MACROSCOPIC: Received were 19 slides, labelle:: L 0 MICROSCOPIC: IDo- At the request of. the slides have been reviewed. I agree with the G diagnosis of adrenal cortical carcinoma diagnosed by The Y tumour is composed of variably pleomorphic cells, which are arrangea in ditfuse sheets, nests and cords. The cells have enlarged hyperchromatic nucleai. I C There are scattered cells with markedly atypical nuclei, including 3 multi-nucleated forms. Occasional mitoses are present (up to 3/50 hpf). Atypical mitoses are not identified. The cells have variable amounts of eosinophilic granular cytoplasm. Cell borders are indistinct. There is a prominent myxoid stroma throughout the tumour. There are also prominent vessels. There is no capsular or venous space invasion, however sinusoida! invasion is seen in one area.. Corticas Immunohistochemistry was performed. The tumour cells are positive with A calretinin and melin A.The tumour demonstrates four of the nine Weiss C 74. N criteria, comprising high nuclear grade, loss of clear cells, diffuse architecture and sinusoidal invasion. In view of this, and the large size of A the tumour, it is best regarded as an adrenal cortical carcinoma. 83701 T SUMMARY: 0 Right adrenal gland - Adrenal cortical carcinoma. M T-93010 M-83703 c A px eUsCupenay form fhn Tss 5:ttes L REPORTING PATHOLOGIST: (Electronic Signature) hish4g, h bc myx0iL. lw P 8/13 Myxoid A T H 0 L 0
+
+--- Page 2 ---
+A HISTOPATHOLOGY FOR REVIEW T 0 Slides were reviewed at the request of treating surgeon). Thise. L review is part of a project examining comparative genomic hybridisation on 0 adrenal tissue frozen at the time of surgery and involves centralised histopathological review including assignment of a Weiss score to a large G number of adrenal tumours. Y Pathological Diagnosis: Adrenal Cortical Carcinoma Weight of Adrenal Gland: 148g Weiss score with number of Weiss criteria present:4 High nuclear grade. Less than 25% Clear cells Diffuse architecture Sinusoidal invasion Note: Many of the cells have oxyphilic cytoplasm imparting an oncocytoma like appearance A N SUMMARY: Adrenal Gland: Adrenal cortical carcinoma. Weiss score:4 A T T-93000 M-81400 0 M 1 REPORTING PATHOLOGIST: c (Electronic Signature) A L P A T H 0 PE'S S) L Page 1 of 1 0 G Y  Where'Collected' indilcates Rec:
+
+--- Page 3 ---
+AUUHONAL REPORT COPIES SENT TO Requested: HISTOPATHOLOGY THIS TOP SECTION MAY bE DETACHED PRIOR TO FILiNG Sex: HISTOPATHOLOGY REPORT MACROSCOPIC: "Right adrenal gland". The specimen consists of a previously opened,. encapsulated oval tumour 148g and 85x55x70mm. The capsule is shiny and grey with a small amount of adnerent adrenal gland and fat but the vast majority of  the specimen is composed of tumour which has a variegated yellow to tan cut surface with prominent areas ot haemorrhage. Representative sections.. (Blocks A to L, wlth B including a tiny amount of attached adrenal gland) CAC4. MICROSCOPIC: The adrenal cortex is replaced by a tumour composed of loosely cohesive cells with plentiful eosinophilic cytoplasm and round nuclel. There Is considerable  cellular pleomorphism with'trequent large hyperchromatic nuclel. The cells are arranged in cords and sheets and in many places are separated by pools of mucinous material. In the more pleomorphlc areas, there are up to three mitoses 13 per ten high power fields. Many of the cells contain PAS positive globules. There is no evidence of capsular or vascular invasion. The tumour cells fail to stain tor S100 protein, chromogranin A or calretinin. The appearance Is in keeping with ah adrenocortical carcinoma.. ADRENOCORTICAL CARCINOMA DIAGNOSIS: RIGHT ADRENAL GLAND - Page 1 Continued Over.
+
+--- Page 4 ---
+V4.10 TCGA Pathologic Diagnosis Discrepancy Form Instructions; The TCGA.Pathologic Diagnosis Discrepancy Form should be completed when the pathologic diagnosis documented on the initial pathology report for a case submitted for TcGA is inconsistent with the diagnosis provided on the Case Quality Control Form completed for the submitted case.. Tissue Source Site (TSS): _TSS Identifier: . T$$ Unique Patient Identitier. Completed By (Interviewer Name on. Completed Date: Diagnosis Information Data Element Entry Alternatives # Working Instructions Provide the diagnosis/ histologic subtype(s) documented on Pathologic Diagnosis Usua! the inttial pathology report for this case. If the histology for this case Is mixed, provide all listed sublypes.. Provided on Initial Pathology Report  Provide the histologic features selected on the TCGA Case Histologic features'of-' Myxed Quality Control Form completed for this case. the sample provided for TCGA, as reflected on the CQCF. Discrepancy betweenPathology Reporrand Case Quality ControlForm Provide the reason for  Provide a reason describing why the diagnosis on the initial MyxoiI feans one  pathology report for this case is not consistent with the the discrepancy diagnosis selected on the TCGA Case Quality Control Form.  between the pathology report and the TCGA srev-i g no hp Case Quality Contro! Form. sehu we hwe, JW Way k Knu hW ukudui fhe ae i He uhb j Name of TSS Reviewing Provide the name of the pathologist who reviewed this case for TCGA. Pathologist or  Biorepository Director I acknowl. vided by my Institution is true and correct and has been quality controlled.. TSS Reviewi : Director IDate I acknowledge that the a rtian nravided by my Institution is true and currect and has been quolity controlleu. The Attending Pathologist or the nformed or is aware of the above discrepancy in diagnoses.. re Date I P
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diff --git a/output/text/fee7cb0d-8715-426d-8b42-97ace70ca957.txt b/output/text/fee7cb0d-8715-426d-8b42-97ace70ca957.txt
new file mode 100644
index 0000000000000000000000000000000000000000..f7cbcf30a09e94d67a85a38d6163087693c41d2f
--- /dev/null
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+--- Page 1 ---
+UUID:0FDC2801-71F8-4D45-BFF1-89445E621A41 TCGA-AR-A256-01A-PR  Redacted Final Diagnosis Lw y/os1n ast, right,) mastectomy:. Infiltrating ductal carcinoma, Nottingham in-situ is not identified (AJcc pT2). Surgical margins and nipple are negative for tumor.. Lymph nodes, right sentinel axillary (No. 1 and No. 2) and right axillary, excision: Multiple (3) right sentinel axillary lymph nodes and (2) right. axillary lymph nodes are negative for tumor.. Breast, right, biopsy:. Small fragment of skin and adipose tissue,. negative for tumor. Breast, left, mastectomy: Proliferative fibrocystic changes characterized. A single 0.5 cm fibroadenoma with myxoid degeneration is identified.. Immunohistochemical studies with antibodies against cytokeratin show the. sentinel lymph nodes #1 and #2 to be negative for metastatic carcinoma.. Immunohistochemical stains for estrogen and progesterone receptors are negative in neoplastic cells.. 1cs-0-3 carcima infi2tnaAhg duct N0s 85o0/3 Sin: brsst, Nos C50.9 4/051 4
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diff --git a/output/text/ff17f160-d4b2-46d6-8f47-dd3f559e9205.txt b/output/text/ff17f160-d4b2-46d6-8f47-dd3f559e9205.txt
new file mode 100644
index 0000000000000000000000000000000000000000..1abeb6b49f0151eda00889a659b43341f9c0bcdd
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+Page 1 of 7 UUID:176B5C21-B423-418E-AFAB-565E58E5404C TCGA-K4-A54R-01A-PR Redacted Name Encounter Numbe. COPY ONLY DO NOt fiLE SURGICAL PATHOLO Time Collected Time Received Time Reported Order Number Ordering Provider Status Resuits Correction Source of Specimen A. LEFT DISTAL URETER MARGIN FS- B. RIGHT DISTAL URETER MARGIN FS- C. DISTAL URETHRAL MARGIN OF RADICAL CYSTECTOMY SPECIMEN FS- D. LEFT PELVIC LYMPH NODE- E. RIGHT PELVIC LYMPH NODE- F. BLADDER AND PROSTATE GLAND, SEMINAL VESICLES- Reason for Correction Ics-0-3 TO CORRECT TYPOGRAPHICAL ERROR. cascioma, ivrs#hulhP Nos 8/xo/3 Sitx : blnddw, dome FINAL DIAGNOSIS: C u7.1 A. LEFT DISTAL URETER MARGIN FS- SEGMENT OF URETER, NO TUMOR SEEN. B. RIGHT DISTAL URETER MARGIN FS- 1/3/12 SEGMENT OF URETER, NO TUMOR SEEN. C. DISTAL URETHRAL MARGIN OF RADICAL CYSTECTOMY SPECIMEN FS- NO TUMOR SEEN IN URETHRAL MUCOSA. PROSTATE TISSUE, SEE SPECIMEN "F". D. LEFT PELVIC LYMPH NODE- FOUR LYMPH NODES, NO TUMOR SEEN. E. RIGHT PELVIC LYMPH NODE- FOUR LYMPH NODES, NO TUMOR SEEN. F. BLADDER AND PROSTATE GLAND, SEMINAL VESICLES- INVASIVE CARCINOMA, HIGH GRADE. TUMOR SITE: DOME, URINARY BLADDER. Prepared
+
+--- Page 2 ---
+Page 2 of 7 HISTOLOgIC TyPE: UROTHELIAL. SQUAMOUS DIFFERENTIATION:S IS PRESENT. GLANDULAR DIFFERENTIATION:S IS NOT PRESENT. TUMOR SIZE: 2.5 CM. HISTOLOGIC GRADE: 3/3. DEPTH OF INVASION: DEEP PORTION OF MUSCULARIS PROPRIA. SPECIMEN TYPE: CYSTECTOMY/PROSTATECTOMY TNM STAGE: pT2b, pNO, pMX. (T2a: inner half; T2b, outer half) (N1, single pelvic node; N2, multiple pelvic nodes; N3, common iliac node) LYMPH NODE(S) INCLUDED IN ALL PARTS: NUMBER INVOLVED : 0 NUMBER EXAMINED: LYMPHATIC (SMALL VESSEL) INVASION: NOT SEEN. ASSOCIATED EPITHELIAL LESIONS: IDENTIFIED. NO TUMOR SEEN AT MARGIN(S). PROSTATE ADENOCARCINOMA, GLEASON 3+3=6/10 ADENOCARCINOMA OF PROSTATE. NO EXTRAPROSTATIC EXTENSION SEEN. TUMOR SITE: BILATERAL, APEX AND PERIPHERAL ZONES SPECIMEN TYPE: CYSTOPROSTATECTOMY GLEASON SCORE (PRIMARY + SECONDARY PATTERN): 3 + 4 = 7/10. TERTIARY PATTERN: NOT PRESENT. SEVERITY IN EXTENT OF TUMOR: 1 /5. (1: <5%; 2: 5-15%; 3: 15-30%: 4: 30-50%; 5: > 50% tissue involvement). DOMINANT NODULE (AT LEAST 1 CM IN SIZE) : NOT PRESENT Prepared f
+
+--- Page 3 ---
+Page 3 of 7 TREATMENT EFFECT ON CARCINOMA: NOT IDENTIFIED TNM STAGE: pT2c, pNO, pMX. (T2a = one side, < 50%; T2b = one side, > 50%; T2c = bilateral) (NO: negative node;  N1: positive regional node) LYMPHATIC (SMALL VESSEL) INVASION: NOT SEEN. PERINEURAL INVASION: NOT PRESENT. NO TUMOR SEEN IN SEMINAL VESICLES NO TUMOR SEEN AT SPECIMEN MARGINS. Signed Others. Frozen Section A. RIGHT DISTAL URETER- NO TUMOR SEEN. LEFT DISTAL URETER- NO TUMOR SEEN. DISTAL URETHRAL MARGIN FROM RADICAL CYSTECTOMY- NO TUMOR SEEN. Case clinical Information  MUSCLE INVASIVE TRANSITIONAL CELL CARCINOMA OF BLADDER Gross Description A. Received in formalin labeled with the patient's name and. "left distal ureter margin-Fs" is a 0.7 cm frozen section tissue remnant with a pinpoint lumen identified. Wrapped and entirely submitted in Al. B. Received in formalin labeled with the patient's name and. "right distal ureter margin-Fs" is a 0.8 cm frozen section tissue remnant with a pinpoint lumen identified. Wrapped and. entirely submitted in B1. c. Received in formalin labeled with the patient's name and. "distal urethral margin of radical cystectomy specimen-Fs" is a Prepared for Ie
+
+--- Page 4 ---
+Page 4 of 7 3 x 2 x 0.5 cm thick frozen section tissue remnant. Entirely submitted in C1. D. Received in formalin labeled with the patient's name and "left pelvic lymph node" are four nodules of tan adipose tissue consistent with lymphoid tissue ranging in size from 2 cm down to 1.5 cm. The excess fat is trimmed. All four nodes are submitted entirely as follows: D1- one lymph node bisected; D2= one lymph node bisected; D3-D4- one lymph node bisected; D5-D6= one lymph node bisected.. E. Received in formalin labeled with the patient's name and "right pelvic lymph node" are four nodules of tan fatty tissue. All four nodules are submitted as follows: E1-E2- one lymph node. bisected; E3- one single lymph node; E4= one single lymph node; E5-E6= one lymph node bisected.. F. Received in formalin labeled with the patient's name and "bladder, prostate gland and seminal vesicles" is a radical cystectomy specimen with attached fat measuring 16 x 11 x 7 cm. The attached prostate measures 4.5 x 4 x 4 cm. A 3 cm defect is. identified on the prostatic urethral margin. This is grossly consistent with tissue taken for frozen section evaluation. The specimen is inked black on the left and blue on the right. The right seminal vesicle measures 5 x 1 x 1 cm. The right vas deferens measures 7 cm in length. The left seminal vesicle measures 5 x 1 x 1 cm. The left vas deferens measures 11 cm in length. The left and right ureters are embedded in the fat and have been previously taken for frozen section evaluation. The bladder is opened anteriorly and in the dome of the bladder a circumscribed tan, friable mass is identified measuring 2.4 x 2 x 1 cm. The remainder of the bladder mucosa has a retracted cobble-stoned appearance. No additional gross tumor is identified. The cut surface of the mass has a very friable tan. glistening appearance and grossly appears to have invaded into the muscularis. The posterior bladder all on cut surface is grossly unremarkable. The left and right lateral bladder walls are serially sectioned and are grossly unremarkable. The right side of the prostate is serially sectioned to reveal a focally nodular tan-pink grossly unremarkable parenchyma. The left prostate is serially sectioned and in the lower one third the parenchyma reveals a 1 cm cyst that is lined with a smooth tissue.  The lumen contains a clear fluid. Representative sections of the specimen are submitted as follows: F1-F3= mass at dome on right side; F4-F6- mass at dome on left side; F7-F8- right posterior wall; F9-Flo- left posterior wall; Fll-F13= right lateral wall; Fl4-F16= left lateral wall; F17- right trigone; F18= left trigone; F19-F2l= representative sections of upper, mid and lower one third of prostate, right side; F22-F24=. representative sections of upper, mid and lower one third of prostate, left side. Also, F24 demonstrates cystic structure on. Additional sections Prepared t
+
+--- Page 5 ---
+Page 5 of 7 submitted as follows: F25-F27= additional full thickness cross sections of prostate upper, mid and lower one third right side; F28-F30= representative sections of upper, mid and lower one third of prostate left side. dure A. AA ROUTINE H&E X1 BLOCK H&E X1 B. AA ROUTINE H&E X1 BLOCK H&E X1 C. AA ROUTINE H&E X1 BLOCK H&E X1 D. AA ROUTINE H&E X1 BLOCK.1 H&E X1 D. AA ROUTINE H&E X1 BLOCK.2 H&E X1 D. AA ROUTINE H&E X1 BLOCK.3 H&E X1 D. AA ROUTINE H&E X1 BLOCK.4 H&E X1 D. AA ROUTINE H&E X1 BLOCK.5 H&E X1 D. AA ROUTINE H&E X1 BLOCK.6 H&E X1 E. AA ROUTINE H&E X1 BLOCK.1 H&E X1 E. AA ROUTINE H&E X1 BLOCK.2 H&E X1 E. AA ROUTINE H&E X1 BLOCK.3 H&E X1 E. AA ROUTINE H&E X1 BLOCK.4 H&E X1 E. AA ROUTINE H&E X1 BLOCK.5 H&E X1 E. AA ROUTINE H&E X1 BLOCK.6 H&E X1 F. AA ROUTINE H&E X1 BLOCK.1 H&E X1 F. AA ROUTINE H&E X1 BLOCK.2 H&E X1 F. AA ROUTINE H&E X1 BLOCK.3 H&E X1 F. AA ROUTINE H&E X1 BLOCK.4 H&E X1 F. AA ROUTINE H&E X1 BLOCK.5 Prepared f.
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+Page 6 of 7 H&E X1 F. AA ROUTINE H&E X1 BLOCK.6 H&E X1 F. AA ROUTINE H&E X1 BLOCK.7 H&E X1 F. AA ROUTINE H&E X1 BLOCK.8 H&E X1 F. AA ROUTINE H&E X1 BLOCK.9 H&E X1 F. AA ROUTINE H&E X1 BLOCK.10 H&E X1 F. AA ROUTINE H&E X1 BLOCK.11 H&E X1 F. AA ROUTINE H&E X1 BLOCK.12 H&E X1 F. AA ROUTINE H&E X1 BLOCK.13 H&E X1 F. AA ROUTINE H&E X1 BLOCK.14 H&E X1 F. AA ROUTINE H&E X1 BLOCK.15 H&E X1 F. AA ROUTINE H&E X1 BLOCK.16 H&E X1 F. AA ROUTINE H&E X1 BLOCK.17 H&E X1 F. AA ROUTINE H&E X1 BLOCK.18 H&E X1 F. AA ROUTINE H&E X1 BLOCK.19 H&E X1 F. AA ROUTINE H&E X1 BLOCK.20 H&E X1 F. AA ROUTINE H&E X1 BLOCK.21 H&E X1 F. AA ROUTINE H&E X1 BLOCK.22 H&E X1 F. AA ROUTINE H&E X1 BLOCK.23 H&E X1 F. AA ROUTINE H&E X1 BLOCK.24 H&E X1 F. AA ROUTINE H&E X1 BLOCK.25 H&E X1 F. AA ROUTINE H&E X1 BLOCK.26 H&E X1 F. AA ROUTINE H&E X1 BLOCK.27 H&E X1 F. AA ROUTINE H&E X1 BLOCK.28 H&E X1 F. AA ROUTINE H&E X1 BLOCK.29 H&E X1 Prepared
+
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+Page 7 of 7 F. AA ROUTINE H&E X1 BLOCK.30 H&E X1 Prepared
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+
+--- Page 1 ---
+Dg I 1cs-6-3 caucnema, ni pi1tnatng !obitin:Nos"8530]3 Sits: Erast. Nos c50.9 UUID:810663DD-1718-4FD6-B9C2-77B4C091B3F1 TCGA-AC-A23G-01A-PR Redacted Collected Recelved: Accessio! Reported: Aoct/Rg SURGICAL PATHOLOGY REPORT DIAGNOSISA J.s, excision: B. Right breast, masteclomy: "Areas of anglolymphatc Invaslon suggested. No in situ component Identified. Histologically unremarkable nipple and negative inked deep surgical margin of resection. Background of prollferative fibrocystic changes inciuding moderate usual ductal hyperplasla and a single mlcroscopic focus of atypical ducta!  hyperplasia. Ancillary studies previously obtained. C. Right axillary contents, reglonal resection: Metastatic adenocarclnom eayxtsotstsyaaroarse The largest lymph node shows a multifocal microgranulomatous reaction associated wth refractile foreign material. Staging sheet #25 Stage: T1cN1MX, stage iIa : Electronic Signature:  ClInICAl hIstoRy: Preoperative Diagnosis: Right breast cancet Postoperative Dlagnosis:  Symptoms/Radtologic Findings: Crite epanc SPECIMENS: A. Right axillary sentinel nodes 8. Right breast C. Right axllary contents SQU.ALIF!E Gross DescrIptIOn: A. The first contalnes Ais labeled were examined at the time of surgery and are subsequently entirely submitted In cassettes  and conslsts of two lymph nodes measuring 1.2 x 1.0 x 0.5 cm and 1.5 x 1.2 x 0.5 cm. The lymph nodes B. The'second contalner 8 is labeled. s follows: FSA1--1; FSA2--2.  inked and sectioned with attached skin measuring 25.0 x 15.0 x 6.0 cm and weighs 830 grams. The skin surface measures 20.0 x 9.0 cm and Is iight nd right breast and consists of a portion of fibroadipose breast tissue that has been received previously tan wrinkied. There is an area discolored by blue contast dye surrounding the nipple measuring 6.0 cm. The nipple is centrally placed and appears  grossty normal. The specimen has orlented wilh a suture at superior. On sectloning there is a firm gray-tan fibrous mass measuring 1.2 x 1.0 x 0.7 cm that is 1.0 cm from the deep margin of resecton and is located predominanty within the upper inner quadrant. Tha surrounding breast tissue reveals epresentative sectlons are submitted in cassettes  nasssectonsfo Om upper Inner quadrant--7; lower Inner quadrant--; lower outer quadrant-; upper outer quadrant--10.  as follows: nipp!e--1; sections from mass--2 C. The third container C is labeled. Sectioning reveals twelve probable lymph nodes measuring from 0.2 to 1.5 cm. The lymph nodes are entirely submitted in cassette. Ad right axillary contents and consists of a portion of fibroadlpose tissue measuring 8.0.x 5.5 x as
+
+--- Page 2 ---
+foltows: five probable nodes--1; six probable nodes-2; one lymph node trisected--3 and 4. InTrA-OPERATIVE COnSULTATION:E FSA: 'Metastatic neoplasm in at leasl one of the two lymph noxdes.
+
+--- Page 3 ---
+to be rofered to a breast surgeon; Patient was called with results and will followup withj necossary surgloal refexral Hor the *r*END OF ADDENBUM ** VOICR TO TEXT SYNOPSIS ADDENDUM *** Invasive lobular carcinoma/Patient needs to be refeqred to a surg :ADS: (6) Known blopsy - proven malignancy +BND OP ADDENDUM *** FULL RESULT: Indication: Right breast rnassktntansoand guldrarsarstaiops Vacuum-asslsted uitrasound-guided 'core biopsy: Scana through the right breast at 1:00 agaln confirm a solld Irregular mass. It has shadowing posterlory. Following local anesthesla, a 10-gauge Cassi device was Introduced into tha mass under ultresound guldance. using vacuum asslstance, multiple core samp!es were obtalned. Procedure was woll tolerated. Clip placement: Under ultrasound guidance, a biopsy cilp was Inserted percutaneously into the area of the mass. Thls was successtully deployed under uitrasound guldance. Right mammogram, post procedure: A postbiopsy mammogram was obtained. Thla confirms placement of the biopsy marker clip. It is well within the spiculated mass in the upper inner quadrant. ImpRESSiON: Irregular solld mass right breast at  deployed successfully into the blopsy site. Pathology pending.: . Ultrasound-guided vacuum-assisted core blopsy performed. Cllp
+
+--- Page 4 ---
+Collected: Accession #: Received. Acct / Rog #: 1 Reported: SURGICA PATHOLOGYREPORT ADDENDUM REPORT ADDENDUM REPORT NUMBER TWO BrEAst pRoGnostic PanEL: Biock 2 Test RESULT REFERENCE RANGES DNA Analysi. by Jmage:* DNA Index: SEE COMMENI 0.9 -1.1 is Diplold  0.9 or > 1.1 i Aneuplold COmuent: insufficient tumor volume is present for quantitation of DnA by iImage analysit. Her2 Gene Anplification By FISH: NEGATIVE Averaga copies per cali: Her-2/nou: 1.82 Chromosome 17: 1.67 Ratio: 1.09 > 20 Har2/neu Case interpretad by? Notes: *Quantitative analysis performed using Chromavlsion ACis.d The Har2 /neu and CEP17 probee are manufactured by Vysis inc.d The Her2/neu gene detecton by Fluoreecence in Situ Hybridization (Fish} was porformod using the LSl Her?/neu DNA probe, specific for the Her2ineu gene locue 17q11.2-q12 and the CEp1 DNA probe specific for the aipha satellite DNA sequence at the centromoric - reglon of chromosome 17 (17p11.1-q11.1) Thoee tosts were developed and porformance characteristics determined by the.d They heve not been cieared or approved by the Us Food and Orug Administration. The FoA has detarmined that such approval or ciearance is not neceseary. Thoes tauts ars used for dinicai purpoeee. They showld not be regarded as inveetigetional or for reeearch. This  aboratory is certified under the Clinical Laboratory Improvement Act (CtiA} of 1sss a quaAtiad to perform high complexity cnicad. laboratory testing. Piace of Servlce: Center for Advanced Diagnostic. Addandun Report Irsuod By: ADDENDUM REPORT NUMBER ONE BRmAst PROGNOsTIC PAnEL: (Pre!minary test r*sults on biock A2).d TEST RESULT REFERENCE RANGES Estrogen Receptor: POSme (94%) > 4% 1s Positive 2.4% Is Borderline < 2% Is Nagative Progesterone Receptor: POS(TYE (69%) > 4% is Pozitive 2-4% is Borderine < 2% Is Negative Kl-67 (MI81) Proliferaton Marker: BQRDERLINE (18%) > 20% Is High t0-20% is Bordertine <10% is Low REPORTCONTINUDONN
+
+--- Page 5 ---
+PATIENT INFORMATION These resuits were Interpretod by Drdd An additiona! addendum report will follow wten DNA and Her-2-neu testsd are completed. These tests were developed and performance characteristics dotermined by. hey have not been cloared or approved by. the Us Food and Drug Adrninistration. The FDA hxs dotormined that auch approvai or clearance is not necessary. Theee tests are ueed for clinlcal purposes. They should not be regarded as investigational or for research. This laboratory Is certified under the Clnicai Laboratory Improvement Act (CtiA) of 198s as qualifiod to perfom hignh complaxity clinicai Iaboratory testing. Addendum Reoort Issued By: DIAGNOSIS: Invasive lobular carcinoma.d Stxe: Two cores partially involved witn largest linear dkntntion 5 mm as measured trom slide A2. Elston modification of Bloom-Richardson Grude: Architectural score: 3/3. Nuclear score: 2/3. Mitote score: 1/3. Total score: 6/9-. No In situ carcInoma component prosont. No iymphovascular space invasion evident. No microcalcificatone soen. No other signiflcant proliferative breast disease pattern present.d Paraftin Biock A2 subnitted for breast cancer prognostio panel with resuits reported as an addendum (pararin block A5 suitable if additional material necessary).d Electronlc Signature: CLINICAL INFORMATION CLinIcal histoRy: Preoperative Disgnosis: Core noodie biopsy, true cut, ulrasound core biopsy ancllary toet # mallgnant Estrogen/Progosterone recoptors, Her2-nou Postoperative Dlagnosis: Symptoma/Radioioglc Findings: Mamnogram, uXresound, size trregular mass 1 x 2 cm SPECIMENS: Right breast SPECIMENDATA Gross Description: Rocetved in one container labeled :  ight breasl are muitiple (15 to 20) sot pait yoigw wispy fragnonts and conm measuring up to 1.2 cm in. greatest dimension. The specinen is entrety submitted in five cassettes labeled Cass color blue.
\ No newline at end of file
diff --git a/output/text/ff3d6557-0dbf-49aa-abe9-b8c249b45dc1.txt b/output/text/ff3d6557-0dbf-49aa-abe9-b8c249b45dc1.txt
new file mode 100644
index 0000000000000000000000000000000000000000..c8347dc7b2d17fdbf5f71f121aaf21ed9b1fa1d1
--- /dev/null
+++ b/output/text/ff3d6557-0dbf-49aa-abe9-b8c249b45dc1.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+*** Diagnosis / Diagnoses: *** Ileocolic resectate under inclusion of a moderately differentiated adenocarcinoma of the colorectal type, located in the cecum and of max. 5.5 cm in size, with infiltration of the pericolic fatty tissue. No regional lymph node metastases. Small and large intestinal resection margins tumor-free. Mesenteric resection margin tumor-free. A secondary finding is two submucosal lipomas in the ascending colon. Tumor stage thus: pT3 pN0 (0/27) pMX; G2, L0, V0, R0
\ No newline at end of file
diff --git a/output/text/ff651cc6-db63-4637-b0e4-84ada73ccd1f.txt b/output/text/ff651cc6-db63-4637-b0e4-84ada73ccd1f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..0e9d911f19a49b73cfebee52702c987e0ac40d2c
--- /dev/null
+++ b/output/text/ff651cc6-db63-4637-b0e4-84ada73ccd1f.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+page 1 / 1 Department of Cancer Pathology. copy No. Date: Examination: Histopathological examination Internal invoice No. Value of diagnostic procedure Examination No. Patient: XXX PESEL: XXX Age: Gender: F 1cs-0-3 Material: Multiple organ resection -- left breast!. Carciomn nFi/tnuHny dusf,nos 85oof3 Unit in charge: Sih:busot, N0s C50.9 Physician in charge: Material collected on:. Material received on' Expected time of examination: up to 8 working days. Clinical diagnosis: Cancer of the left breast.. PCI: Carcinonia invasivum G3. Examination performed on: Results of immunohistochemical examination:  No estrogen receptors detected in neoplastic cell nuclei. Progesterone receptors found in less than 10% of neoplastic cell  nuclei. HER2 protein stained with Ventana's Pathway HER-2/neu (4B5) Rabbit Monoclonal Antibody. Negative reaction in invasive cancerous cells (Score=1+).. Compliance validat Examination performed on Macroscopic description:  Left breast, sized 26 x 18 x 5 cm, removed along with axillary tissues sized 4 x 1 x 2 cm and a skin flap of 16 x 11 cm. Weight 220 g. Tumour sized 3.5 x 2.5 x 3.0 cm found in the upper inner quadrant, located 4 cm from the upper edge, 0.5 cm from the base and 3.8 cm from the skin. Microscopic description:. Carcinoma ductale invasivum - NHG3 (3+3+2: 9 mitoses/10 HPF - visual area: 0.55mm). Mamilla sine laesionibus Glandular tissue showing lesions: mastopathia fibrosa. Axillary lymph nodes: Lymphonodulitis chronica (No I ). Histopathological diagnosis: Carcinoma ductale invasivum mammae sinistrae. Invasive ductal carcinoma of the left breast.* (NHG3, p 12, pNO). Compliance validated by: CONTACT YOUR DOCTOR WITH THIS REPORT! JUID:BD71F606-58BC-46B9-8A03-CB25D5BECA96 Redacted >n
\ No newline at end of file
diff --git a/output/text/ff829992-12bd-4e9f-9cb6-9e20c39c92db.txt b/output/text/ff829992-12bd-4e9f-9cb6-9e20c39c92db.txt
new file mode 100644
index 0000000000000000000000000000000000000000..d78a9265f1dc5c53609868e17c700cdc6c4e9bb1
--- /dev/null
+++ b/output/text/ff829992-12bd-4e9f-9cb6-9e20c39c92db.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+UUID:9EC72159-5123-48AD-BBBC-DF2F1B6FAF3D TCGA-5M-AATA-01A-PR Redacted Io3 derDcsreunomo N05 8l4o13 denocareunso s,tubelar 8Q11f3 Date: Dite : SigmsieLcileS C18.7 SPECIMEN: Sigmoid colon, rectum, anal canal fJ e/2s/14 PROCEDURE: Excision of the rectum and anal canal MACROSCOPY - Two bottles were received. Bottle #1 -- Identification: "Rectosigmoid, rectum, anal canal" - Segment of large intestine measuring 65.0 cm in length and 4.0 cm in median diameter. - An ulcerated lesion measuring 8.0 x 3.2 cm and 1.6 cm thick can be found in the mucosa less. than 0.5 cm of the presumed distal margin. - Another segment previously opened along its greater axis measuring 5.2 cm in length and 3.6. cm in diameter was assumed to be the rectum, and displayed no grossly pathologic features - A nodular, indurated structure measuring 1.6 x 0.6 x 0.3 cm was dissected from the segment of. colon. Bottle #2 -- Identification: "Polyp" - Fragment of pale, soft, irregular tissue measuring 0.3 x 0.2 x 0.2 cm. MICROSCOPIC EXAMINATION Bottle #1 - Moderately differentiated tubular adenocarcinoma; - Microscopic tumor extension: tumor penetrates to the subserosa; - Perineural invasion: not observed; - Lymph-vascular invasion: not observed; - Moderate desmoplastic stromal reaction, mild intratumoral and peritumoral inflammatory. infiltrate. - Surgical margins free of neoplastic involvement; - Number of lymph nodes examined: 5; - Number of lymph nodes involved: 2; - Stage: pT3 pN1 Bottle #2 - Tubular adenoma with low grade epithelial dysplasia. PATHOLOGISTS W adt Tumor Site Dis Dual/Sync
\ No newline at end of file
diff --git a/output/text/ff90667a-234d-4dea-a8ab-21c757acf187.txt b/output/text/ff90667a-234d-4dea-a8ab-21c757acf187.txt
new file mode 100644
index 0000000000000000000000000000000000000000..15d1a9a94d49e03b2fc94c5eeb9a0fe0328c88de
--- /dev/null
+++ b/output/text/ff90667a-234d-4dea-a8ab-21c757acf187.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Jcs -0-3 1rH- sifu. Brast, UsQ C50.7 C9cF Sih; Gusot,nos C5v.9 Diagnosis: 1. Invasive carcinoma (tumor diameter: 2.5 cm) with focal slight intraductal spread. Invasion of lymph vessels.. In conclusion this is a poorly differentiated lobular carcinoma.. Tumor classification: lobular carcinoma, G IIl, pT2N3aL1V0RX. UUID:B73AF7B0-EED3-413C-B249-C97F27E4EA1C TCGA-A8-A09W-01A-PR Redacted
\ No newline at end of file
diff --git a/output/text/ff9a61a9-594b-4262-9a2a-93c6d582470a.txt b/output/text/ff9a61a9-594b-4262-9a2a-93c6d582470a.txt
new file mode 100644
index 0000000000000000000000000000000000000000..175d166ed6d6f3b7ffe9c9362a6a83989d7ae11c
--- /dev/null
+++ b/output/text/ff9a61a9-594b-4262-9a2a-93c6d582470a.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Diagnosis: 1. : Resected ileocolic material with a moderately differentiated colorectal adenocarcinoma located in the cecum, measuring a max of 3.8 cm in diameter and with circumscribed infiltration of the pericecal adipose tissue and with ten regional/ local lymph node metastases. Tumor-free small and large intestine resection. margins. Tumor-free mesenteric resection margin. Evidence of lymphangiosis carcinomatosa also in the perityphlitic adipose tissue as well as in the tunica muscularis propria of the appendix. Tumor-free omental adipose tissue.. 2. : Resected colon with circumscribed ulcerous mucous membrane defect displaying. a condition following an ablation of a colorectal adenocarcinoma infiltrating the submucosa. No further sections of the neoplasia diagnosed previously. Tumor-free 1ymph nodes in the region. Tumor-free colon resection margins and accompanying colon wall tourniquet. Tumor stage relating to 1: pT3, pN2 (10/20) pMX; G2, L1, V0, local R0 Tumor stage relating to 2: pT1, pN0 (0/6) pMX; G2, L0, V0, R0. Diagnosis: 1. : Resected liver tissue with a bilious hamartoma (so-called Meyenburg complex). 2. : Further tumor-free resected liver with small bile duct cysts and pericystic scarred. area. 3. : Superficial resected liver tissue with scarred capsular area. No signs of. malignancy and in particular no metastasis of a colon carcinoma in the material at hand.
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diff --git a/output/text/ffcaaa91-172c-44a0-a31b-2d35501e547f.txt b/output/text/ffcaaa91-172c-44a0-a31b-2d35501e547f.txt
new file mode 100644
index 0000000000000000000000000000000000000000..fe8e5659417ae389c0b75baa3c50ba79aa87bf28
--- /dev/null
+++ b/output/text/ffcaaa91-172c-44a0-a31b-2d35501e547f.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+Patient history: CHIEF COMPLAINT/PRE-OP/POST-OP DiAGNOSIS: Right rena! mass PROCEDURE: Right radical nephrectomy SPECIFIC CLINICAL QUESTION: No OUTSIDE TISSUE DIAGNOSIS; NO +- PRIOR MALIGNANCY: No CHEMORADIATION THERAPY: No ORGAN TRANSPLANT: No IMMUNOSUPPRESSION: No OTHER DISEASES: No FINAL DIAGNOSIS: KIDNEY, RIGHT, RADICAL NEPHRECTOMY -- A.  PapillAary Renal Cell Carcinoma, type 2. B. FuHrman nUcLeAr GraDe iS 3 Of 4. C. THE CARCINOMA MEASURES 9.0 CM IN GREATEST DIMENSION. D.  THE CARCINOMA GROSSLY INVADES THE RENAL VEIN AND IS SEEN EXTENDING BEYOND THE RENAL VEIN RESECTION MARGIN E. THE NON-NEOPLASTIC KIDNEy SHOWS INTERSTITIAL INFLAmMATION, GLOmERULOSCLEROSIS AND ARTERIOSCLEROSIS. F. PATHOLOGICAL STAGE: pT3a N0 MX ($EE SYNOPTIC) CASE SYNOPSIS: SYNOPTIC DATA - PRIMARy KIDNEy TUMORS SPeCImen TyPE:  Radical nephrectomy LATERALITY: Right Tumor site: Middie FOCALITY: Unifocal TUMOR SIZE: Greatest dimension: 9.0 cm Additional dirmensions: 7.0 x 5.5 cm MACROSCOPIC EXTENT OF TUMOR: Tumor extension into major veins. HistologiC Type: Papillary renal cell carcinoma HISTOLOGIC GRADE (Fuhrman Nuclear Grade): G3 PAThOLOgiC STAGing (ptnm): pT3a pNX  Number of regional lymph nodes examined: 0. pMX MARGINS: Margin(s) involved by invasive carcinoma Renal vein margin ADRENAL GLAND: Not present LYMPH-VA$CULAR INVASION (LVI): Present/identified ADDITIONAL PATHOLOGIC FINDINGS: Inflammation (type): chronic interstitial inflammation. Glomerular disease (type): glomerulosclerosis KIDNEY-RESIDUAL TUMOR (R): R2
\ No newline at end of file
diff --git a/output/text/ffe25ca3-1b88-4326-9eb7-adde0340c40b.txt b/output/text/ffe25ca3-1b88-4326-9eb7-adde0340c40b.txt
new file mode 100644
index 0000000000000000000000000000000000000000..a04d4682f74a9aad08a1fdf26567f6801470b949
--- /dev/null
+++ b/output/text/ffe25ca3-1b88-4326-9eb7-adde0340c40b.txt
@@ -0,0 +1,6 @@
+
+--- Page 1 ---
+Clinical Diagnosis & History: Right kidney tumor. Specimens Submitted: 1:SP:Kidney,right superior pole margin,biopsy 2:SP:Kidney,right,partial nephrectomy DIAGNOSIS: 1. Soft tissue,"superior pole margin right kidney,biopsy: Benign adipose tissue. 2. SP:Kidney,right, partial nephrectomy: Tumor Type: Renal cell carcinoma -Unclassified type Seenote Tumor Size: Greatest diameter is2.5 cm. Local Invasion (for renal cortical types): Not Identified Renal Vein Invasion: Not identified Surgical Margins: Free of tumor Non-Neoplastic Kidney Unremarkable Adrenal Gland: Not identified Lymph Nodes: Not identified Staging for renal cell carcinoma/oncocytoma: pT1 Tumor <= 7.0 cm in greatest dimension limited to thekidney Note:The tumor shows mixed features with both tubulopapillary and cystic architecture and is comprised of cells with abundant eosinophilic cytoplasm,frequent cytoplasmic vacuoles,and round, overall uniform nuclei. These findings are compatible with a low grade renal cell carcinoma.This case was seen in consultation with ho concurs with the diagnosis. Page 1 of2
+
+--- Page 2 ---
+IATTEST THAT THE ABOVE DIAGNOSIS IS BASED UPON MY PERSONAL EXAMINATION OF THE SLIDES (AND/OR OTHER MATERIAL)AND THAT I HAVE REVIEWEDAND APPROVEDTHIS REPORT, Gross Description: 1).The specimen is received fresh for frozen section consultation, labeled "superior pole marginright kidney tumor and consists of three fragments of tan tissue measuring 0.7 x 0.6 x 0.5 cm.Entirely submitted for frozen section. Summary of sections FSC--frozen section control 2).The specimen is received fresh for frozen section and is labeled right kidney tumor suture on the base.It consists of a 2.9 x 2.5 x 2.5 cm wedge shaped portion of kidney with a suture marking the deep margin. The margin is inked black and the specimen is serially sectioned to reveal a yellow-brown mass measuring 2.5 x2.5 x 2.5 cm.The clearance from the resection margin is 0.2 cm. A representative section of the nearest margin is submitted for frozen section diagnosis. Representatively submitted. Summary of sections: FSC-frozen section control T-tumor M-margin RS-representative sections Summary of Sections: Part 1:SP:Kidney,right superior pole margin, biopsy Block Sect.Site PCs 1 fsc Part 2:SP:Kidney,rightpartial nephrectomy Block Sect.Site PCs 1 fsc 1 1 m 1 1 rs 1 2 t 2 Intraoperative Consultation: Note: The diagnoses given in this section pertain only to the tissue sample examinedat the time of the intraoperative consultation. 1) FROZENSECTION DIAGNOSIS:BENIGN FIBROFATTY TISSUE. PERMANENT DIAGNOSIS: SAME 2) FROZEN SECTION DIAGNOSIS:RENAL CORTICAL TUMOR.MARGIN ISFREE (APPROXIMATELY2 MM CLEARANCE) PERMANENT DIAGNOSIS: SAME Page2of2 END OFREPORT
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diff --git a/output/text/fffe45f7-dc46-41bf-bfe4-4d14c8208d6e.txt b/output/text/fffe45f7-dc46-41bf-bfe4-4d14c8208d6e.txt
new file mode 100644
index 0000000000000000000000000000000000000000..e0d7f4bafef0aa4d982097f340658ea1e718ffae
--- /dev/null
+++ b/output/text/fffe45f7-dc46-41bf-bfe4-4d14c8208d6e.txt
@@ -0,0 +1,3 @@
+
+--- Page 1 ---
+1 UUID: BBF67449-D59A-46C6-A180-A7546607ED87 TCGA-B1-A47N-01A-PR Redacted FINAL DIAGNOSIS: Collection Date: Part 1: fat OverLying tumor, excision -- A.  BENIGN FtBROADIPOSE TISSUE. B.  No tumor seen. Part 2: Capsule Overlying tumOr, eXcisiOn -- A.  BENIGN FIBROADIPOSE TISSUE WITH CHRONIC INFLAMMATION.E B. no tumor seen. Part 3: Left kidney tumor, partial nephrctomy --  PAPILLAry RENAL CeLl CARCiNOmA, Type 1, MAXImAl fUHRmAn nUCLEAR GrADe 3 anD PREdOMINAIT A. NUCLEAR GRADE 2 OUT OF 4 (See comment). B. TUmOR IS LimITeD TO ThE KiDney AnD MEASURES 2.2 x 1.9 x 0.8 CM. C. TumOR IS fOcally PRESeNt AT inKED SURFACE; fOR FinAl MArGIn STaTUS, SEE PARtS 1, 2 & 4. D.  NO VascuLAr InvasioN is iDenTiFIeD. E. TNM PATHOLOGIC STAGE: pT1a Nx Mx (See synoptic). Part 4: renal tumor, Deep margin, excision -- A.  benign renal parenchyma with patchy Chronic interstitial infLAmmation. B. - no tumor seen. COMMENT: Part 3: Immunohistochemlstry shows tumor diffusely and strongly positive for CK7 and racemase (P504S). Tumor gt t ? focal positivity for CD1o. This immunohistochemical profile is consistent with a papillary renal cell carcinoma. CASE SYNOPSIS: SYNOPTiC DATA - PRIMARY KiDNEY TUMORS Specimen type: Partial nephrectomy LATERALITY: Left TUMOR SITE: "Not specified FOCALITY: Unifocal TUMOR SIZE: Greatest dimenslon: 2.2 cm. Additional dimenslons: 1.9 x 0.8 cm  MACROSCOPIC EXTENT OF TUMOR: Tumor limited to kidney HIstolOgic'Type: Papillary renal cell carcinoma. HISTOLOGIC GRADE (Fuhrman Nuclear Grade): G3 PathoLOgiC StAging (ptnm): pT1a pNX : Number of regional (ymph nodes examined: 0 pMX MARGINS: Margins uninvoived by invasive carcinoma. ADRENAL GLAND: Not present LYMPH-VASCULAR INVASION (LVI): Absent/not identified Stte:.. Kidiy; Nos CC4:q
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diff --git a/requirements.txt b/requirements.txt
index 28d994e22f8dd432b51df193562052e315ad95f7..a5a197ddafc578503a85a8c2b17ec3c7aa2a1dac 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -1,3 +1,25 @@
-altair
+numpy>=1.26.4
+
+torch>=2.3.0
+torchvision>=0.18.0
+torchaudio>=2.3.0
+
+transformers>=4.41.0
+sentence-transformers>=3.0.0
+accelerate>=0.30.0
+
+faiss-cpu>=1.8.0
+rank-bm25
+
+google-genai
+
 pandas
-streamlit
\ No newline at end of file
+scikit-learn
+tqdm
+
+pillow
+pdf2image
+pytesseract
+pymupdf
+
+gradio>=4.0
\ No newline at end of file
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index 0000000000000000000000000000000000000000..5a3efe1dc17fb866405fdd941c390b08f7bb10ba
--- /dev/null
+++ b/src/document_processor.py
@@ -0,0 +1,218 @@
+#!/usr/bin/env python3
+"""
+Dynamic RAG Database Updater
+Processes new PDFs and updates the vector database in real-time
+
+"""
+
+import os
+import json
+import numpy as np
+from pathlib import Path
+from typing import List, Dict
+import pickle
+from datetime import datetime
+
+# PDF processing
+from pdf2image import convert_from_path
+
+# OCR (CPU optimized)
+from paddleocr import PaddleOCR
+
+# Embeddings
+from sentence_transformers import SentenceTransformer
+
+# FAISS (CPU)
+import faiss
+
+
+class DynamicRAGUpdater:
+    """
+    Handles dynamic updates to RAG database:
+    1. Upload PDF
+    2. OCR extraction (PaddleOCR CPU)
+    3. Generate embeddings (BiomedBERT)
+    4. Update FAISS index
+    5. Update metadata
+    """
+
+    def __init__(
+        self,
+        vector_db_path: str,
+        embedding_model: str = "microsoft/BiomedNLP-BiomedBERT-base-uncased-abstract-fulltext",
+        upload_dir: str = "uploaded_reports"
+    ):
+        self.vector_db_path = Path(vector_db_path)
+        self.upload_dir = Path(upload_dir)
+        self.upload_dir.mkdir(exist_ok=True)
+
+        self.ocr_dir = self.upload_dir / "ocr_text"
+        self.embeddings_dir = self.upload_dir / "embeddings"
+        self.ocr_dir.mkdir(exist_ok=True)
+        self.embeddings_dir.mkdir(exist_ok=True)
+
+        # PaddleOCR (explicit CPU mode)
+        self.ocr = PaddleOCR(
+            use_angle_cls=True,
+            lang="en",
+            cpu_threads=4,
+            enable_mkldnn=True
+        )
+
+        # BiomedBERT only
+        self.embedding_model = SentenceTransformer(
+            embedding_model,
+            device="cpu"
+        )
+
+        self.embedding_dim = self.embedding_model.get_sentence_embedding_dimension()
+
+        self.load_database()
+
+    def load_database(self):
+        index_file = self.vector_db_path / "faiss.index"
+        metadata_file = self.vector_db_path / "metadata.pkl"
+
+        self.faiss_index = faiss.read_index(str(index_file))
+
+        with open(metadata_file, "rb") as f:
+            data = pickle.load(f)
+            self.chunks = data["chunks"]
+            self.chunk_id_to_idx = data["chunk_id_to_idx"]
+
+    def save_database(self):
+        faiss.write_index(self.faiss_index, str(self.vector_db_path / "faiss.index"))
+
+        with open(self.vector_db_path / "metadata.pkl", "wb") as f:
+            pickle.dump(
+                {
+                    "chunks": self.chunks,
+                    "chunk_id_to_idx": self.chunk_id_to_idx,
+                    "embedding_dim": self.embedding_dim,
+                    "model": "microsoft/BiomedNLP-BiomedBERT-base-uncased-abstract-fulltext"
+                },
+                f
+            )
+
+    def extract_text_from_pdf(self, pdf_path: str) -> str:
+        images = convert_from_path(pdf_path, dpi=300)
+
+        full_text = []
+
+        for page_num, image in enumerate(images, 1):
+            image_np = np.array(image)
+            ocr_result = self.ocr.ocr(image_np, cls=True)
+
+            page_text = []
+            if ocr_result and ocr_result[0]:
+                for line in ocr_result[0]:
+                    page_text.append(line[1][0])
+
+            full_text.append(
+                f"\n{'='*50}\nPAGE {page_num}\n{'='*50}\n" +
+                "\n".join(page_text)
+            )
+
+        return "\n".join(full_text)
+
+    def chunk_text(self, text: str, chunk_size: int = 512) -> List[str]:
+        sentences = text.split(". ")
+        chunks = []
+        current = []
+        length = 0
+
+        for s in sentences:
+            s = s.strip()
+            if not s:
+                continue
+
+            s = s + ". "
+            if length + len(s) > chunk_size and current:
+                chunks.append("".join(current))
+                current = [s]
+                length = len(s)
+            else:
+                current.append(s)
+                length += len(s)
+
+        if current:
+            chunks.append("".join(current))
+
+        return chunks
+
+    def generate_embeddings(self, chunks: List[str]) -> np.ndarray:
+        return self.embedding_model.encode(
+            chunks,
+            batch_size=32,
+            convert_to_numpy=True,
+            show_progress_bar=True
+        )
+
+    def add_to_database(
+        self,
+        embeddings: np.ndarray,
+        chunks: List[str],
+        filename: str
+    ) -> int:
+        start_idx = self.faiss_index.ntotal
+        self.faiss_index.add(embeddings.astype("float32"))
+
+        for i, text in enumerate(chunks):
+            meta = {
+                "chunk_id": start_idx + i,
+                "text": text,
+                "filename": filename,
+                "upload_date": datetime.now().isoformat(),
+                "source": "user_upload"
+            }
+            self.chunks.append(meta)
+            self.chunk_id_to_idx[f"{filename}_{i}"] = start_idx + i
+
+        return len(embeddings)
+
+    def process_and_add_pdf(self, pdf_path: str) -> Dict:
+        start = datetime.now()
+        filename = Path(pdf_path).stem
+
+        text = self.extract_text_from_pdf(pdf_path)
+        (self.ocr_dir / f"{filename}.txt").write_text(text, encoding="utf-8")
+
+        chunks = self.chunk_text(text)
+        embeddings = self.generate_embeddings(chunks)
+
+        np.save(self.embeddings_dir / f"{filename}_embeddings.npy", embeddings)
+
+        vectors_added = self.add_to_database(embeddings, chunks, filename)
+        self.save_database()
+
+        return {
+            "filename": filename,
+            "text_length": len(text),
+            "num_chunks": len(chunks),
+            "vectors_added": vectors_added,
+            "total_vectors": self.faiss_index.ntotal,
+            "processing_time_seconds": (datetime.now() - start).total_seconds(),
+            "timestamp": datetime.now().isoformat()
+        }
+
+
+def main():
+    vector_db_path = "/usr/users/3d_dimension_est/selva_sur/RAG/output/biomedbert_vector_db"
+
+    updater = DynamicRAGUpdater(
+        vector_db_path=vector_db_path,
+        embedding_model="microsoft/BiomedNLP-BiomedBERT-base-uncased-abstract-fulltext",
+        upload_dir="uploaded_reports"
+    )
+
+    test_pdf = "path/to/new_report.pdf"
+
+    if Path(test_pdf).exists():
+        stats = updater.process_and_add_pdf(test_pdf)
+        print(json.dumps(stats, indent=2))
+    else:
+        print("Test PDF not found. Update the path in main().")
+
+
+if __name__ == "__main__":
+    main()
diff --git a/src/embeddings.py b/src/embeddings.py
new file mode 100644
index 0000000000000000000000000000000000000000..b642a66d33753c90451fc6da99757b06a9d11e97
--- /dev/null
+++ b/src/embeddings.py
@@ -0,0 +1,239 @@
+#!/usr/bin/env python3
+"""
+Biomedical NLP Pipeline - Using Microsoft BiomedBERT
+
+"""
+
+from pathlib import Path
+import json
+from datetime import datetime
+from typing import List, Dict
+from tqdm import tqdm
+
+# Microsoft BiomedBERT
+from sentence_transformers import SentenceTransformer
+
+# spaCy for NER
+try:
+    import spacy
+    SPACY_AVAILABLE = True
+except ImportError:
+    SPACY_AVAILABLE = False
+    print("spaCy not available. Install: pip install spacy scispacy")
+
+
+class BiomedBERTPipeline:
+    """
+    Pipeline using Microsoft BiomedBERT embeddings + spaCy NER
+    """
+    
+    def __init__(self, biomedbert_model: str = "microsoft/BiomedNLP-BiomedBERT-base-uncased-abstract-fulltext"):
+        """
+        Initialize with Microsoft BiomedBERT
+        
+        Args:
+            biomedbert_model: HuggingFace model name
+        """
+        print(f" Loading Microsoft BiomedBERT: {biomedbert_model}")
+        print("   (First run downloads ~400MB, then cached)")
+        
+        self.embedder = SentenceTransformer(biomedbert_model)
+        
+        print(f" BiomedBERT loaded (embedding dim: {self.embedder.get_sentence_embedding_dimension()})")
+        
+        # Load spaCy medical model
+        if SPACY_AVAILABLE:
+            print(" Loading medical spaCy model...")
+            try:
+                # Try medical model first
+                self.nlp = spacy.load("en_core_sci_md")
+                print("Medical spaCy model (en_core_sci_md) loaded")
+            except:
+                try:
+                    # Fallback to general model
+                    self.nlp = spacy.load("en_core_web_sm")
+                    print(" General spaCy model (en_core_web_sm) loaded")
+                except:
+                    print("  No spaCy model found. Running without NER.")
+                    self.nlp = None
+        else:
+            self.nlp = None
+    
+    def process_text(self, text: str) -> Dict:
+        """
+        Process text with BiomedBERT embeddings + NER
+        
+        Args:
+            text: Input text
+        
+        Returns:
+            Dict with embeddings and entities
+        """
+        result = {
+            "timestamp": datetime.now().isoformat(),
+            "embeddings": None,
+            "entities": []
+        }
+        
+        # Generate embeddings with BiomedBERT
+        embedding = self.embedder.encode(text, convert_to_numpy=True)
+        result["embeddings"] = embedding.tolist()
+        
+        # Extract entities with spaCy
+        if self.nlp:
+            doc = self.nlp(text)
+            for ent in doc.ents:
+                result["entities"].append({
+                    "text": ent.text,
+                    "type": ent.label_,
+                    "start": ent.start_char,
+                    "end": ent.end_char
+                })
+        
+        return result
+    
+    def process_directory(self, input_dir: str, output_dir: str, save_embeddings: bool = True):
+        """
+        Process all text files in directory
+        
+        Args:
+            input_dir: Directory with text files
+            output_dir: Output directory
+            save_embeddings: Whether to save embeddings (can be large!)
+        """
+        input_dir = Path(input_dir)
+        output_dir = Path(output_dir)
+        output_dir.mkdir(parents=True, exist_ok=True)
+        
+        files = list(input_dir.glob("*.txt"))
+        
+        if not files:
+            print(f" No .txt files found in {input_dir}")
+            return []
+        
+        print(f"\n Found {len(files)} text files")
+        print(f" Processing with Microsoft BiomedBERT...\n")
+        
+        all_results = []
+        success_count = 0
+        failed_count = 0
+        
+        for txt_file in tqdm(files, desc="Processing files"):
+            try:
+                text = txt_file.read_text(encoding="utf-8")
+                
+                result = self.process_text(text)
+                result["filename"] = txt_file.stem
+                
+                # Don't save embeddings to JSON (too large)
+                # Save them separately if needed
+                if save_embeddings:
+                    # Save embeddings as numpy
+                    import numpy as np
+                    emb_file = output_dir / f"{txt_file.stem}_embedding.npy"
+                    np.save(emb_file, result["embeddings"])
+                
+                # Save entities and metadata (without embeddings)
+                output_data = {
+                    "filename": result["filename"],
+                    "timestamp": result["timestamp"],
+                    "entities": result["entities"],
+                    "entity_count": len(result["entities"]),
+                    "has_embedding": save_embeddings
+                }
+                
+                out_file = output_dir / f"{txt_file.stem}_nlp.json"
+                with open(out_file, "w") as f:
+                    json.dump(output_data, f, indent=2)
+                
+                all_results.append(output_data)
+                success_count += 1
+                
+                if success_count % 100 == 0:
+                    print(f"\n Progress: {success_count}/{len(files)} files")
+                
+            except Exception as e:
+                failed_count += 1
+                print(f"\n  FAILED | {txt_file.name} | {e}")
+        
+        print(f"\n{'='*70}")
+        print(f"PROCESSING COMPLETE")
+        print(f"{'='*70}")
+        print(f"Total files   : {len(files)}")
+        print(f"Successful    : {success_count}")
+        print(f"Failed        : {failed_count}")
+        print(f"Success rate  : {(success_count/len(files)*100):.1f}%")
+        print(f"{'='*70}")
+        
+        self._save_summary(all_results, output_dir)
+        return all_results
+    
+    def _save_summary(self, results: List[Dict], output_dir: Path):
+        """Save processing summary"""
+        summary = {
+            "total_files": len(results),
+            "total_entities": sum(len(r["entities"]) for r in results),
+            "timestamp": datetime.now().isoformat(),
+            "entity_types": {},
+            "model": "microsoft/BiomedNLP-BiomedBERT-base-uncased-abstract-fulltext"
+        }
+        
+        for r in results:
+            for e in r["entities"]:
+                summary["entity_types"][e["type"]] = \
+                    summary["entity_types"].get(e["type"], 0) + 1
+        
+        with open(output_dir / "processing_summary.json", "w") as f:
+            json.dump(summary, f, indent=2)
+        
+        print("\n" + "=" * 70)
+        print("BIOMEDBERT PROCESSING SUMMARY")
+        print("=" * 70)
+        print(f"Model         : Microsoft BiomedBERT")
+        print(f"Total entities: {summary['total_entities']:,}")
+        print(f"\nTop Entity Types:")
+        sorted_types = sorted(summary["entity_types"].items(), 
+                            key=lambda x: x[1], reverse=True)
+        for etype, count in sorted_types[:15]:
+            print(f"  {etype:20s} : {count:6,}")
+        print("=" * 70)
+
+
+def main():
+    """Main function"""
+    print("= " * 20)
+    print("MICROSOFT BIOMEDBERT PIPELINE")
+    print("= " * 20)
+    
+    # CONFIGURE PATHS
+    input_dir = "/usr/users/3d_dimension_est/selva_sur/RAG/output/text"
+    output_dir = "/usr/users/3d_dimension_est/selva_sur/RAG/output/biomedbert_output"
+    
+    print(f"\nConfiguration:")
+    print(f"  Input  : {input_dir}")
+    print(f"  Output : {output_dir}")
+    print(f"\nModel:")
+    print(f"  • Microsoft BiomedBERT (HuggingFace)")
+    print(f"  • spaCy medical NER")
+    print("="*70)
+    
+    try:
+        pipeline = BiomedBERTPipeline()
+        
+        results = pipeline.process_directory(
+            input_dir=input_dir,
+            output_dir=output_dir,
+            save_embeddings=True  # Set False to save space
+        )
+        
+        print(f"\n COMPLETE: {len(results)} files processed")
+        print(f"Results: {output_dir}")
+        
+    except Exception as e:
+        print(f"\n Error: {e}")
+        import traceback
+        traceback.print_exc()
+
+
+if __name__ == "__main__":
+    main()
diff --git a/src/llm_handler.py b/src/llm_handler.py
new file mode 100644
index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391
diff --git a/src/oc.py b/src/oc.py
new file mode 100644
index 0000000000000000000000000000000000000000..b5d47e7b34cb48cccafc92750efb780ceb4d32d7
--- /dev/null
+++ b/src/oc.py
@@ -0,0 +1,156 @@
+#!/usr/bin/env python3
+"""
+Direct GDC PDF OCR without downloading - streams PDFs from GDC API
+"""
+
+from pathlib import Path
+from tqdm import tqdm
+import fitz  # PyMuPDF
+from paddleocr import PaddleOCR
+from PIL import Image
+import numpy as np
+import requests
+import io
+import time
+
+# Paths
+OUTPUT_DIR = Path("paddleocr_results/text")
+OUTPUT_DIR.mkdir(parents=True, exist_ok=True)
+
+# Initialize OCR once
+ocr = PaddleOCR(
+    lang="en",
+    use_textline_orientation=True,
+    device="gpu"
+)
+
+
+def download_pdf_to_memory(file_id):
+    """Download PDF from GDC API directly to memory."""
+    url = f"https://api.gdc.cancer.gov/data/{file_id}"
+    
+    try:
+        response = requests.get(url, stream=True, timeout=60)
+        response.raise_for_status()
+        
+        # Read PDF into memory
+        pdf_bytes = io.BytesIO()
+        for chunk in response.iter_content(chunk_size=1024*1024):
+            if chunk:
+                pdf_bytes.write(chunk)
+        
+        pdf_bytes.seek(0)
+        return pdf_bytes
+        
+    except Exception as e:
+        raise RuntimeError(f"Failed to download: {e}")
+
+
+def pdf_to_images(pdf_bytes):
+    """Convert PDF bytes to PIL images."""
+    doc = fitz.open(stream=pdf_bytes, filetype="pdf")
+    images = []
+
+    for page in doc:
+        pix = page.get_pixmap(dpi=200)
+        img = Image.frombytes("RGB", [pix.width, pix.height], pix.samples)
+        images.append(img)
+
+    doc.close()
+    return images
+
+
+def ocr_pdf_from_gdc(file_id):
+    """Download PDF from GDC and perform OCR."""
+    # Download PDF to memory
+    pdf_bytes = download_pdf_to_memory(file_id)
+    
+    # Convert to images
+    images = pdf_to_images(pdf_bytes)
+    all_text = []
+
+    for page_idx, img in enumerate(images, 1):
+        img_np = np.array(img)
+
+        result = ocr.ocr(img_np, cls=True)
+        if result and result[0]:
+            page_text = " ".join([line[1][0] for line in result[0]])
+            all_text.append(f"\n--- Page {page_idx} ---\n{page_text}")
+
+    return "\n".join(all_text)
+
+
+def main():
+    # Read manifest file
+    manifest_file = "/usr/users/3d_dimension_est/selva_sur/RAG/data/file_ids.txt" 
+    
+    if not Path(manifest_file).exists():
+        print(f" ERROR: Manifest file not found: {manifest_file}")
+        return
+    
+    with open(manifest_file, 'r') as f:
+        lines = f.readlines()[1:]  # Skip header
+    
+    file_ids = [line.split('\t')[0].strip() for line in lines if line.strip()]
+    
+    # Process all files (or limit for testing)
+    # file_ids = file_ids[:100]  # Uncomment to test with first 100
+    
+    print("\n" + "=" * 70)
+    print("PADDLEOCR – DIRECT GDC PDF OCR (NO DOWNLOAD)")
+    print("=" * 70)
+    print(f"Manifest file    : {manifest_file}")
+    print(f"Output directory : {OUTPUT_DIR}")
+    print(f"Files to process : {len(file_ids):,}")
+    print(f"Device           : GPU")
+    print("=" * 70 + "\n")
+
+    success, failed = 0, 0
+    total_chars = 0
+    failed_ids = []
+
+    for file_id in tqdm(file_ids, desc="Processing PDFs", unit="files"):
+        try:
+            # OCR the PDF directly from GDC
+            text = ocr_pdf_from_gdc(file_id)
+
+            if not text.strip():
+                raise RuntimeError("No text extracted")
+
+            # Save output
+            out_file = OUTPUT_DIR / f"{file_id}.txt"
+            out_file.write_text(text, encoding="utf-8")
+
+            total_chars += len(text)
+            success += 1
+
+        except Exception as e:
+            failed += 1
+            failed_ids.append(file_id)
+            tqdm.write(f" {file_id}: {e}")
+        
+        # Small delay to avoid hammering the API
+        time.sleep(0.1)
+
+    print("\n" + "=" * 70)
+    print("OCR SUMMARY")
+    print("=" * 70)
+    print(f"Total attempted : {len(file_ids):,}")
+    print(f"Successful      : {success:,}")
+    print(f"Failed          : {failed:,}")
+    print(f"Success rate    : {100 * success / max(len(file_ids), 1):.1f}%")
+    print(f"Total text      : {total_chars:,} chars")
+    print("=" * 70)
+    
+    # Save failed IDs
+    if failed_ids:
+        failed_file = OUTPUT_DIR / "failed_ocr_ids.txt"
+        with open(failed_file, 'w') as f:
+            f.write("file_id\n")
+            for fid in failed_ids:
+                f.write(f"{fid}\n")
+        print(f"\n  Failed file IDs saved to: {failed_file}")
+
+
+if __name__ == "__main__":
+    main()
diff --git a/src/retriever.py b/src/retriever.py
new file mode 100644
index 0000000000000000000000000000000000000000..99a0085ff1eddc836c36932bb7da666b35ab0f82
--- /dev/null
+++ b/src/retriever.py
@@ -0,0 +1,454 @@
+#!/usr/bin/env python3
+"""
+Complete Medical RAG Pipeline
+Query → Hybrid Retrieval → Cross-Encoder Rerank → Gemini Answer
+Features
+--------
+• FAISS semantic retrieval
+• BM25 keyword retrieval
+• Hybrid score fusion
+• Cross-encoder reranking
+• Gemini medical QA generation
+• Report specific filtering (dropdown support)
+"""
+
+import os
+import re
+import pickle
+import time
+import numpy as np
+from pathlib import Path
+from datetime import datetime
+from typing import List, Dict, Optional
+
+import faiss
+from rank_bm25 import BM25Okapi
+
+from sentence_transformers import SentenceTransformer, CrossEncoder
+from google import genai
+
+
+# ============================================
+# CONFIG
+# ============================================
+
+DEFAULT_TOP_K = 5
+
+
+# ============================================
+# QUERY PROCESSOR
+# ============================================
+
+class MedicalQueryProcessor:
+
+    def __init__(self, embedding_model: str):
+
+        print(f"Loading embedding model: {embedding_model}")
+
+        self.model = SentenceTransformer(embedding_model)
+
+        self.dim = self.model.get_sentence_embedding_dimension()
+
+        print(f"Embedding dimension: {self.dim}")
+
+    def extract_keywords(self, query: str) -> List[str]:
+
+        patterns = [
+            r"\b(cancer|carcinoma|tumor|neoplasm)\b",
+            r"\b(ER|PR|HER2)\b",
+            r"\b(stage\s*[IVX]+)\b",
+            r"\b(grade\s*[123])\b",
+            r"\b(lymph\s*node)\b",
+        ]
+
+        found = []
+
+        for p in patterns:
+            found.extend(re.findall(p, query, flags=re.I))
+
+        return list(set(found))
+
+    def embed(self, text: str) -> np.ndarray:
+
+        return self.model.encode(
+            text,
+            normalize_embeddings=True
+        )
+
+    def process(self, query: str) -> Dict:
+
+        return {
+            "query": query,
+            "keywords": self.extract_keywords(query),
+            "embedding": self.embed(query),
+        }
+
+
+# ============================================
+# HYBRID RETRIEVER
+# ============================================
+
+class HybridRetriever:
+
+    def __init__(self, faiss_db_path: str):
+
+        db = Path(faiss_db_path)
+
+        print(f"Loading FAISS index from: {db}")
+
+        self.index = faiss.read_index(str(db / "faiss.index"))
+
+        with open(db / "metadata.pkl", "rb") as f:
+            data = pickle.load(f)
+
+        self.chunks = data["chunks"]
+
+        print(f"Loaded {len(self.chunks)} chunks")
+
+        tokenized = [
+            c["text"].lower().split()
+            for c in self.chunks
+        ]
+
+        self.bm25 = BM25Okapi(tokenized)
+
+    def get_available_reports(self) -> List[str]:
+
+        return sorted({
+            c["filename"]
+            for c in self.chunks
+        })
+
+    def search(
+        self,
+        query_embedding: np.ndarray,
+        query_text: str,
+        top_k: int = 40
+    ) -> List[Dict]:
+
+        # -----------------------------------
+        # FAISS SEMANTIC SEARCH
+        # -----------------------------------
+
+        distances, indices = self.index.search(
+            query_embedding.reshape(1, -1).astype("float32"),
+            top_k
+        )
+
+        faiss_scores = {}
+
+        for idx, dist in zip(indices[0], distances[0]):
+
+            if idx >= 0:
+                faiss_scores[int(idx)] = float(dist)
+
+        if not faiss_scores:
+            return []
+
+        # -----------------------------------
+        # BM25 KEYWORD SEARCH
+        # -----------------------------------
+
+        tokens = query_text.lower().split()
+
+        bm25_raw = self.bm25.get_scores(tokens)
+
+        bm25_max = max(bm25_raw) if max(bm25_raw) > 0 else 1.0
+
+        bm25_scores = {
+            i: bm25_raw[i] / bm25_max
+            for i in faiss_scores.keys()
+        }
+
+        # -----------------------------------
+        # HYBRID SCORE FUSION
+        # -----------------------------------
+
+        fused_scores = {}
+
+        for idx in faiss_scores.keys():
+
+            faiss_score = faiss_scores.get(idx, 0)
+
+            bm25_score = bm25_scores.get(idx, 0)
+
+            fused_scores[idx] = (
+                0.7 * faiss_score +
+                0.3 * bm25_score
+            )
+
+        ranked = sorted(
+            fused_scores.items(),
+            key=lambda x: x[1],
+            reverse=True
+        )
+
+        results = []
+
+        for idx, score in ranked:
+
+            results.append(
+                {
+                    "chunk": self.chunks[idx],
+                    "score": score
+                }
+            )
+
+        return results
+
+
+# ============================================
+# CROSS ENCODER RERANKER
+# ============================================
+
+class MedicalReranker:
+
+    def __init__(self):
+
+        print("Loading cross-encoder reranker...")
+
+        self.model = CrossEncoder(
+            "cross-encoder/ms-marco-MiniLM-L-6-v2"
+        )
+
+        print("Cross-encoder ready")
+
+    def rerank(
+        self,
+        query: str,
+        candidates: List[Dict],
+        top_k: int = DEFAULT_TOP_K
+    ) -> List[Dict]:
+
+        if not candidates:
+            return []
+
+        pairs = [
+            (query, c["chunk"]["text"])
+            for c in candidates
+        ]
+
+        scores = self.model.predict(pairs)
+
+        for c, s in zip(candidates, scores):
+            c["ce_score"] = float(s)
+
+        ranked = sorted(
+            candidates,
+            key=lambda x: x["ce_score"],
+            reverse=True
+        )
+
+        return ranked[:top_k]
+
+
+# ============================================
+# GEMINI GENERATOR
+# ============================================
+
+class GeminiGenerator:
+
+    def __init__(
+        self,
+        model_name="models/gemini-flash-lite-latest"
+    ):
+
+        api_key = os.getenv("GOOGLE_API_KEY")
+
+        if not api_key:
+            raise RuntimeError("GOOGLE_API_KEY not set")
+
+        self.client = genai.Client(api_key=api_key)
+
+        self.model_name = model_name
+
+        print(f"Using Gemini model: {model_name}")
+
+    def generate(
+        self,
+        query: str,
+        chunks: List[Dict]
+    ) -> str:
+
+        if not chunks:
+            return "No relevant information found."
+
+        context = ""
+
+        for i, c in enumerate(chunks, 1):
+            chunk_text = c['chunk'].get('text', '')
+            
+            # If the database was built without the original text files, it defaults to "Document: <filename>"
+            # We can still provide the extracted entities to Gemini so it has context!
+            if chunk_text.startswith("Document:") and "entities" in c['chunk']:
+                entities = [e.get("text", "") for e in c['chunk']["entities"]]
+                chunk_text += "\nExtracted Medical Entities: " + ", ".join(entities)
+
+            context += f"[{i}] {chunk_text}\n\n"
+
+        prompt = f"""
+You are an expert medical assistant. Answer the medical question using ONLY the provided text or entities from the pathology documents below.
+Treat the provided information as your complete source material. Do not state that you cannot access files, as the contents/entities are provided directly below.
+Cite your sources in your text using their corresponding numbers like [1], [2], etc.
+
+--- PROVIDED DOCUMENT CONTENTS / ENTITIES ---
+{context}
+
+--- QUESTION ---
+{query}
+
+--- ANSWER ---
+"""
+
+        try:
+
+            response = self.client.models.generate_content(
+                model=self.model_name,
+                contents=prompt
+            )
+
+            return response.text
+
+        except Exception as e:
+
+            if "RESOURCE_EXHAUSTED" in str(e):
+
+                print("Rate limit reached. Waiting 30 seconds...")
+
+                time.sleep(30)
+
+                response = self.client.models.generate_content(
+                    model=self.model_name,
+                    contents=prompt
+                )
+
+                return response.text
+
+            raise
+
+
+# ============================================
+# COMPLETE RAG PIPELINE
+# ============================================
+
+class CompleteRAGPipeline:
+
+    def __init__(
+        self,
+        faiss_db_path: str,
+        embedding_model: str
+    ):
+
+        print("\nInitializing Medical RAG Pipeline\n")
+
+        self.query_processor = MedicalQueryProcessor(
+            embedding_model
+        )
+
+        self.retriever = HybridRetriever(
+            faiss_db_path
+        )
+
+        self.reranker = MedicalReranker()
+
+        self.llm = GeminiGenerator()
+
+        print("\nPipeline ready\n")
+
+    def get_available_reports(self) -> List[str]:
+        return self.retriever.get_available_reports()
+
+    def ask(
+        self,
+        query: str,
+        report_name: Optional[str] = None,
+        top_k: int = 5
+    ) -> Dict:
+
+        processed = self.query_processor.process(query)
+
+        candidates = self.retriever.search(
+            processed["embedding"],
+            query
+        )
+
+        # ----------------------------------
+        # REPORT FILTERING
+        # ----------------------------------
+
+        if report_name:
+
+            candidates = [
+                c for c in candidates
+                if c["chunk"].get("filename") == report_name
+            ]
+
+            if not candidates:
+
+                return {
+                    "query": query,
+                    "answer": f"No information found for report: {report_name}",
+                    "timestamp": datetime.now().isoformat(),
+                    "sources": [],
+                    "num_sources": 0
+                }
+
+        # ----------------------------------
+        # RERANK
+        # ----------------------------------
+
+        top_chunks = self.reranker.rerank(
+            query,
+            candidates,
+            top_k=top_k
+        )
+
+        # ----------------------------------
+        # GENERATE ANSWER
+        # ----------------------------------
+
+        answer = self.llm.generate(
+            query,
+            top_chunks
+        )
+
+        return {
+            "query": query,
+            "answer": answer,
+            "sources": top_chunks,
+            "timestamp": datetime.now().isoformat(),
+            "num_sources": len(top_chunks)
+        }
+
+
+# ============================================
+# MAIN TEST
+# ============================================
+
+def main():
+
+    FAISS_DB = "output/biomedbert_vector_db"
+
+    EMB_MODEL = "microsoft/BiomedNLP-BiomedBERT-base-uncased-abstract-fulltext"
+
+    pipeline = CompleteRAGPipeline(
+        FAISS_DB,
+        EMB_MODEL
+    )
+
+    reports = pipeline.get_available_reports()
+
+    print("\nAvailable reports:")
+    print(reports)
+
+    result = pipeline.ask(
+        "What abnormal findings are present?",
+        report_name=reports[0] if reports else None
+    )
+
+    print("\nAnswer:\n")
+    print(result["answer"])
+
+
+if __name__ == "__main__":
+    main()
\ No newline at end of file
diff --git a/src/utils.py b/src/utils.py
new file mode 100644
index 0000000000000000000000000000000000000000..e69de29bb2d1d6434b8b29ae775ad8c2e48c5391
diff --git a/src/vectordbs.py b/src/vectordbs.py
new file mode 100644
index 0000000000000000000000000000000000000000..207ca1d7ae78a152e547ab27d34dc8961ae248c3
--- /dev/null
+++ b/src/vectordbs.py
@@ -0,0 +1,276 @@
+#!/usr/bin/env python3
+"""
+BiomedBERT Embeddings → FAISS Vector Database
+Improved pathology-aware chunking strategy
+"""
+
+import json
+import pickle
+import re
+import numpy as np
+from pathlib import Path
+from tqdm import tqdm
+from datetime import datetime
+
+import faiss
+from sentence_transformers import SentenceTransformer
+
+
+class PathologyVectorDB:
+
+    def __init__(
+        self,
+        output_dir="output/biomedbert_vector_db",
+        embedding_model="microsoft/BiomedNLP-BiomedBERT-base-uncased-abstract-fulltext"
+    ):
+
+        self.output_dir = Path(output_dir)
+        self.output_dir.mkdir(parents=True, exist_ok=True)
+
+        print("Loading embedding model...")
+        self.model = SentenceTransformer(embedding_model)
+
+        self.embedding_dim = self.model.get_sentence_embedding_dimension()
+
+        print(f"Embedding dimension: {self.embedding_dim}")
+
+        self.index = faiss.IndexFlatIP(self.embedding_dim)
+
+        self.chunks = []
+
+        self.stats = {
+            "files_processed": 0,
+            "total_chunks": 0,
+        }
+
+    # ----------------------------------------------------
+    # TEXT NORMALIZATION
+    # ----------------------------------------------------
+
+    def normalize_text(self, text):
+
+        text = text.replace("\r", "")
+        text = text.replace("\n\n", "\n")
+
+        return text.strip()
+
+    # ----------------------------------------------------
+    # SECTION SPLITTING
+    # ----------------------------------------------------
+
+    def split_by_sections(self, text):
+
+        pattern = r"\n(?=[A-Z ]{4,}:?)"
+
+        sections = re.split(pattern, text)
+
+        return [s.strip() for s in sections if s.strip()]
+
+    # ----------------------------------------------------
+    # CHUNK CREATION
+    # ----------------------------------------------------
+
+    def create_chunks(self, text, filename,
+                      chunk_size=1200,
+                      overlap=200):
+
+        text = self.normalize_text(text)
+
+        sections = self.split_by_sections(text)
+
+        chunks = []
+
+        chunk_id = 0
+
+        for section in sections:
+
+            start = 0
+            length = len(section)
+
+            while start < length:
+
+                end = start + chunk_size
+
+                chunk_text = section[start:end]
+
+                if len(chunk_text.strip()) > 50:
+
+                    chunk = {
+                        "chunk_id": chunk_id,
+                        "filename": filename,
+                        "text": chunk_text.strip(),
+                    }
+
+                    chunks.append(chunk)
+
+                    chunk_id += 1
+
+                start += chunk_size - overlap
+
+        return chunks
+
+    # ----------------------------------------------------
+    # PROCESS SINGLE FILE
+    # ----------------------------------------------------
+
+    def process_file(self, txt_file):
+
+        filename = txt_file.name
+
+        text = txt_file.read_text(encoding="utf-8", errors="ignore")
+
+        chunks = self.create_chunks(text, filename)
+
+        if not chunks:
+            return [], []
+
+        texts = [c["text"] for c in chunks]
+
+        embeddings = self.model.encode(
+            texts,
+            batch_size=32,
+            normalize_embeddings=True,
+            show_progress_bar=False
+        )
+
+        return embeddings, chunks
+
+    # ----------------------------------------------------
+    # ADD TO FAISS
+    # ----------------------------------------------------
+
+    def add_to_faiss(self, embeddings, chunks):
+
+        embeddings = np.array(embeddings).astype("float32")
+
+        start_idx = self.index.ntotal
+
+        self.index.add(embeddings)
+
+        for i, chunk in enumerate(chunks):
+
+            chunk["faiss_index"] = start_idx + i
+
+            self.chunks.append(chunk)
+
+    # ----------------------------------------------------
+    # PROCESS DIRECTORY
+    # ----------------------------------------------------
+
+    def process_directory(self, text_dir):
+
+        text_dir = Path(text_dir)
+
+        files = list(text_dir.glob("*.txt"))
+
+        if not files:
+            print("No text files found.")
+            return
+
+        print(f"Found {len(files)} pathology reports")
+
+        all_embeddings = []
+        all_chunks = []
+
+        for file in tqdm(files):
+
+            embeddings, chunks = self.process_file(file)
+
+            if len(chunks) == 0:
+                continue
+
+            all_embeddings.extend(embeddings)
+            all_chunks.extend(chunks)
+
+            self.stats["files_processed"] += 1
+
+        if not all_chunks:
+            print("No chunks created")
+            return
+
+        self.stats["total_chunks"] = len(all_chunks)
+
+        embeddings_matrix = np.vstack(all_embeddings)
+
+        print("Adding vectors to FAISS...")
+
+        self.add_to_faiss(embeddings_matrix, all_chunks)
+
+        self.save()
+
+        self.print_summary()
+
+    # ----------------------------------------------------
+    # SAVE DATABASE
+    # ----------------------------------------------------
+
+    def save(self):
+
+        index_file = self.output_dir / "faiss.index"
+
+        faiss.write_index(self.index, str(index_file))
+
+        metadata_file = self.output_dir / "metadata.pkl"
+
+        with open(metadata_file, "wb") as f:
+
+            pickle.dump(
+                {
+                    "chunks": self.chunks,
+                    "embedding_dim": self.embedding_dim,
+                    "model": "BiomedBERT",
+                },
+                f,
+            )
+
+        stats_file = self.output_dir / "stats.json"
+
+        with open(stats_file, "w") as f:
+
+            json.dump(
+                {
+                    **self.stats,
+                    "timestamp": datetime.now().isoformat(),
+                },
+                f,
+                indent=2,
+            )
+
+    # ----------------------------------------------------
+    # SUMMARY
+    # ----------------------------------------------------
+
+    def print_summary(self):
+
+        print("\n=================================")
+        print("VECTOR DATABASE CREATED")
+        print("=================================")
+
+        print(f"Files processed: {self.stats['files_processed']}")
+        print(f"Total chunks: {self.stats['total_chunks']}")
+        print(f"Vectors stored: {self.index.ntotal}")
+
+        print("\nSaved to:")
+        print(self.output_dir)
+
+
+# ----------------------------------------------------
+# MAIN
+# ----------------------------------------------------
+
+def main():
+
+    TEXT_DIR = "output/text"
+    VECTOR_DB = "output/biomedbert_vector_db"
+
+    print("Pathology Vector DB Builder")
+
+    pipeline = PathologyVectorDB(
+        output_dir=VECTOR_DB
+    )
+
+    pipeline.process_directory(TEXT_DIR)
+
+
+if __name__ == "__main__":
+    main()
\ No newline at end of file
diff --git a/test_prompt.py b/test_prompt.py
new file mode 100644
index 0000000000000000000000000000000000000000..ac52d8cff403113c3e4483dcaa7197f31e51d701
--- /dev/null
+++ b/test_prompt.py
@@ -0,0 +1,31 @@
+from src.retriever import CompleteRAGPipeline
+import sys
+
+pipeline = CompleteRAGPipeline(
+    faiss_db_path="output/biomedbert_vector_db",
+    embedding_model="microsoft/BiomedNLP-BiomedBERT-base-uncased-abstract-fulltext"
+)
+
+# Monkey-patch the gemini generator to print the prompt instead of API call
+def mock_generate(self, query: str, chunks: list) -> str:
+    context = ""
+    for i, c in enumerate(chunks, 1):
+        context += f"[{i}] {c['chunk']['text']}\n\n"
+    prompt = f"""
+Answer the medical question using ONLY the sources below.
+Cite sources using [1], [2], etc.
+SOURCES
+{context}
+QUESTION
+{query}
+ANSWER
+"""
+    print("--- PROMPT START ---")
+    print(prompt)
+    print("--- PROMPT END ---")
+    return "Mock Answer"
+
+import src.retriever
+src.retriever.GeminiGenerator.generate = mock_generate
+
+result = pipeline.ask("What abnormal findings are present?", top_k=2)