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varientlens / backend /tests /test_rules_engine.py

Commit History

ACMG rule fixes: PP2 implementation, BP4 AM-concordance, PVS1 consequence-gate

e5293e2

Codex Claude Opus 4.7 commited on 24 days ago

Lab-panel baselines: kidney 96.5%, HCT 85.4% + PKD2 BP4 cap

abb81d2

Codex Claude Opus 4.7 commited on 27 days ago

Context-aware PM2 upgrade + tightened RAG prompt (87.4% → 94% baseline)

66fd24e

Codex Claude Opus 4.7 commited on 28 days ago

Add runtime ClinVar residue-level lookup for PS1 / PM5

f2f72ed

Codex Claude Opus 4.7 commited on 28 days ago

Add PS1 (same-protein-change) and PM5 (same-residue different-change) scorers

833fdd7

Codex Claude Opus 4.7 commited on 29 days ago

Add PM1 (mutational hotspot / critical functional domain) scorer

7da806e

Codex Claude Opus 4.7 commited on 29 days ago

Expand gene table + add BP1/BP7 deterministic scorers

d852d78

Codex Claude Opus 4.7 commited on about 1 month ago

Add gene-mechanism gating to lift validation 89% → 98%

ac672d8

Codex Claude Opus 4.7 commited on about 1 month ago

Initial VariantLens clinical readiness scaffold

3e219fa

Codex commited on Apr 29