Rebuild commit without large PDF
Browse files- .gitattributes +4 -0
- README.md +80 -11
- faiss_index/index.faiss +3 -0
- faiss_index/index.pkl +3 -0
- knowledge/eeg_sig_proc.pdf +3 -0
- main.py +146 -0
- processing.py +179 -0
- rag.py +133 -0
- requirements.txt +20 -0
- visuals.py +123 -0
.gitattributes
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*.zip filter=lfs diff=lfs merge=lfs -text
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*.zst filter=lfs diff=lfs merge=lfs -text
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*tfevents* filter=lfs diff=lfs merge=lfs -text
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*.zip filter=lfs diff=lfs merge=lfs -text
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*.zst filter=lfs diff=lfs merge=lfs -text
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*tfevents* filter=lfs diff=lfs merge=lfs -text
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knowledge/kcc-sleeptextbook-print.pdf filter=lfs diff=lfs merge=lfs -text
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faiss_index/index.faiss filter=lfs diff=lfs merge=lfs -text
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faiss_index/index.pkl filter=lfs diff=lfs merge=lfs -text
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knowledge/eeg_sig_proc.pdf filter=lfs diff=lfs merge=lfs -text
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README.md
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---
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---
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-
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# 🧠 NeuroNap
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**NeuroNap** is an EEG-based sleep analysis tool that processes EEG CSV files to analyze sleep stages, generate hypnograms, visualize frequency spectra, and provide LLM-driven insights using **Gemini**.
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Built with **Python** and **Gradio**, it uses **YASA** for sleep stage classification and **HMM** for clustering and offers an interactive interface for researchers and clinicians studying sleep patterns.
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---
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## 🚀 Features
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- **EEG Processing:**
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Processes raw EEG CSV files using **bandpass** and **notch filters** to remove noise and artifacts, ensuring clean, reliable signal data.
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- **Sleep Stage Classification:**
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Utilizes **YASA** (Yet Another Sleep Analysis) to automatically classify sleep stages — **W, N1, N2, N3, and REM** — and compute essential sleep metrics such as **Total Sleep Time (TST)**, **Sleep Efficiency (SE)**, and **Wake After Sleep Onset (WASO)**.
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- **Clustering:**
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Applies **Hidden Markov Models (HMM)** to cluster EEG-derived features, revealing latent patterns and transitions across sleep stages.
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- **Visualizations:**
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Generates detailed plots for **EEG signals**, **hypnograms**, **frequency spectra**, and **band-specific waveforms**, allowing for intuitive data interpretation.
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- **Sleep Statistics:**
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Displays comprehensive sleep metrics (e.g., **Total Sleep Time**, **Sleep Efficiency**) with expandable tables showing additional parameters like **Time in Bed (TIB)**, **Sleep Period Time (SPT)**, and **latencies**.
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- **LLM Insights:**
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Integrates **Gemini** via **LangChain** for natural language interaction, using a **FAISS vector store** for context-aware sleep data insights.
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- **Exportable Outputs:**
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Enables easy download of results in **CSV** format (clean EEG, extracted features, clusters) and **PDF** format (visual reports and plots).
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---
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## ⚙️ Installation
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```bash
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# Clone the repository
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git clone https://github.com/yourusername/NeuroNap.git
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cd NeuroNap
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# Create a virtual environment
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python -m venv venv
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# Activate the environment
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source venv/bin/activate # On Windows: venv\Scripts\activate
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# Install dependencies
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pip install -r requirements.txt
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```
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🔑 **API Setup**
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Set your Gemini API key in a `.env` file:
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```bash
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echo "GEMINI_API_KEY=your_api_key" > .env
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```
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🧩 **Knowledge Embeddings**
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Before running the app, generate embeddings from your knowledge PDFs:
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```bash
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python rag.py
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```
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Place relevant research papers or notes in the knowledge/ folder before running the above command.
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🖥️ **Usage**
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Launch the Gradio interface:
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```bash
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python main.py
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```
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Then:
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1. **Upload** an EEG CSV file (e.g., `EEGDATA.csv`).
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2. **View** sleep stage visualizations, HMM clusters, and frequency spectra.
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3. **Interact** with the **"Chat with NeuroNap"** feature to get context-aware insights.
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4. **Download** processed data and reports in **CSV** or **PDF** format.
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## 📦 Requirements
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- **Python 3.9+**
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- See `requirements.txt` for the full dependency list
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faiss_index/index.faiss
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version https://git-lfs.github.com/spec/v1
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oid sha256:7f582048dd219190525d0df43072f7dbbc125963dd429eb92acaa45cc0f8b0c2
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size 1379373
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faiss_index/index.pkl
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version https://git-lfs.github.com/spec/v1
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oid sha256:5b7c9149372c508c2578ed9d0507107989e8e8ebd45717fe9ad51d7830278762
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size 928310
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knowledge/eeg_sig_proc.pdf
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version https://git-lfs.github.com/spec/v1
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oid sha256:566380955227b608de4fdc0fdd7e93ba85d11ed34c11e8b97fbd6301e78a5a44
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size 3598747
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main.py
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import gradio as gr
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import pandas as pd
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from processing import process_eeg
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from visuals import plot_eeg_signals, plot_hypnogram, plot_frequency_spectra, plot_band_waveforms
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from rag import setup_rag, chat_with_llm, update_vectorstore_with_user_results
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import os
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import logging
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# Configure logger
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logging.basicConfig(
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level=logging.INFO,
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format='%(asctime)s - %(levelname)s - %(message)s',
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handlers=[
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logging.FileHandler('neuronap.log'),
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logging.StreamHandler()
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]
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)
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logger = logging.getLogger(__name__)
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def analyze_eeg(file):
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logger.info("Starting EEG analysis")
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if file is None:
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logger.error("No CSV file uploaded")
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raise ValueError("No CSV file uploaded.")
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file_path = file.name
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logger.info(f"Processing file: {file_path}")
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eeg_uv, eeg_uv_bp, eeg_uv_notched, hypno, stats, features_df, hmm_labels, fs, time_s = process_eeg(file_path)
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logger.info("EEG processing completed")
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signals_img = plot_eeg_signals(time_s, eeg_uv, eeg_uv_bp, eeg_uv_notched)
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hypno_img = plot_hypnogram(hypno)
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spectra_img = plot_frequency_spectra(eeg_uv_notched, fs)
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bands_img = plot_band_waveforms(eeg_uv_notched, fs)
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# Define key metrics with human-readable names for interface preview
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key_metrics = {
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'TST': 'Total Sleep Time (minutes)',
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'SE': 'Sleep Efficiency (%)',
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'REM': 'REM Sleep (minutes)',
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'N3': 'Deep Sleep (N3) (minutes)',
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'WASO': 'Wake After Sleep Onset (minutes)'
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}
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# Format stats preview for interface default view
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stats_preview = {k: stats.get(k) for k in key_metrics.keys() if k in stats}
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stats_preview_str = "\n".join([
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f"• {key_metrics[k]}: {v:.2f} {'%' if k in ['SE', '%N1', '%N2', '%N3', '%REM', '%NREM', 'SME'] else 'minutes'}"
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for k, v in stats_preview.items()
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])
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# Format full stats for user_results.txt
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stats_full_str = "\n".join([
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f"• {k.replace('_', ' ').title()}: {v:.2f} {'%' if k in ['SE', '%N1', '%N2', '%N3', '%REM', '%NREM', 'SME'] else 'minutes'}"
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for k, v in stats.items()
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])
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# Full stats table for interface expanded view
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stats_full = pd.DataFrame(list(stats.items()), columns=['Metric', 'Value']).to_html(classes='stats-table', index=False)
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# Include full stats in user_results for saving to file
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user_results = f"Sleep Statistics:\n{stats_full_str}\nHypnogram: {hypno}\n"
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logger.info("Updating vectorstore with user results")
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vectorstore = update_vectorstore_with_user_results(user_results)
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qa_chain = setup_rag()
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# Generate previews and full tables for features and clusters
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features_preview = features_df.head(5).to_html(classes='compact-table')
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features_full = features_df.to_html(classes='compact-table')
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clusters_preview = pd.DataFrame({'Cluster': hmm_labels}).head(5).to_html(classes='compact-table')
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clusters_full = pd.DataFrame({'Cluster': hmm_labels}).to_html(classes='compact-table')
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logger.info("Analysis completed, returning outputs")
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return (
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signals_img, hypno_img, spectra_img, bands_img, stats_preview_str, stats_full,
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features_preview, features_full, clusters_preview, clusters_full,
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qa_chain,
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"clean_eeg.csv", "features.csv", "eeg_clusters.csv",
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"eeg_signal_plot.pdf", "hypnogram_plot.pdf", "eeg_fft_welch.pdf", "eeg_bands_plot.pdf"
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)
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def handle_chat(query, qa_chain):
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logger.info(f"Handling chat query: {query}")
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if not query or qa_chain is None:
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logger.warning("Invalid query or no QA chain available")
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return "Please analyze an EEG file first and provide a query."
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return chat_with_llm(query, qa_chain)
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with gr.Blocks(title="NeuroNap", css=".compact-table { font-size: 12px; max-height: 300px; overflow-y: auto; } .stats-table { font-size: 14px; border-collapse: collapse; width: 50%; } .stats-table th, .stats-table td { border: 1px solid #ddd; padding: 8px; text-align: left; }") as demo:
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logger.info("Initializing Gradio interface")
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qa_chain_state = gr.State(None)
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gr.Markdown("# NeuroNap: EEG Sleep Monitoring System")
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with gr.Column():
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with gr.Row():
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file_input = gr.File(label="Upload EEG CSV (e.g., EEGDATA.CSV)")
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analyze_btn = gr.Button("Analyze")
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with gr.Row():
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signals_output = gr.Image(label="EEG Signals")
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hypno_output = gr.Image(label="Hypnogram")
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with gr.Row():
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spectra_output = gr.Image(label="Frequency Spectra")
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bands_output = gr.Image(label="Frequency Bands")
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with gr.Group():
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gr.Markdown("### Sleep Statistics")
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stats_preview_output = gr.Textbox(label="Key Sleep Statistics")
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with gr.Accordion("Show All Sleep Statistics", open=False):
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stats_full_output = gr.HTML(label="Full Statistics")
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with gr.Group():
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gr.Markdown("### Extracted Features")
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features_preview_output = gr.HTML(label="Features Preview")
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with gr.Accordion("Show Full Features Table", open=False):
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features_full_output = gr.HTML(label="Full Features")
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with gr.Group():
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gr.Markdown("### HMM Clusters")
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clusters_preview_output = gr.HTML(label="Clusters Preview")
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| 114 |
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with gr.Accordion("Show Full Clusters Table", open=False):
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clusters_full_output = gr.HTML(label="Full Clusters")
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with gr.Group():
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gr.Markdown("### Chat with NeuroNap")
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chat_input = gr.Textbox(label="Ask about your sleep data", lines=2)
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chat_btn = gr.Button("Send")
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chat_output = gr.Textbox(label="LLM Response", lines=4)
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with gr.Group():
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gr.Markdown("### Downloads")
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with gr.Row():
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clean_csv = gr.File(label="Download clean_eeg.csv")
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+
features_csv = gr.File(label="Download features.csv")
|
| 126 |
+
clusters_csv = gr.File(label="Download eeg_clusters.csv")
|
| 127 |
+
with gr.Row():
|
| 128 |
+
signals_pdf = gr.File(label="Download eeg_signal_plot.pdf")
|
| 129 |
+
hypno_pdf = gr.File(label="Download hypnogram_plot.pdf")
|
| 130 |
+
spectra_pdf = gr.File(label="Download eeg_fft_welch.pdf")
|
| 131 |
+
bands_pdf = gr.File(label="Download eeg_bands_plot.pdf")
|
| 132 |
+
|
| 133 |
+
analyze_btn.click(
|
| 134 |
+
analyze_eeg,
|
| 135 |
+
inputs=file_input,
|
| 136 |
+
outputs=[
|
| 137 |
+
signals_output, hypno_output, spectra_output, bands_output,
|
| 138 |
+
stats_preview_output, stats_full_output,
|
| 139 |
+
features_preview_output, features_full_output, clusters_preview_output, clusters_full_output,
|
| 140 |
+
qa_chain_state, clean_csv, features_csv, clusters_csv, signals_pdf, hypno_pdf, spectra_pdf, bands_pdf
|
| 141 |
+
]
|
| 142 |
+
)
|
| 143 |
+
chat_btn.click(handle_chat, inputs=[chat_input, qa_chain_state], outputs=chat_output)
|
| 144 |
+
|
| 145 |
+
logger.info("Launching Gradio interface")
|
| 146 |
+
demo.launch(share=True)
|
processing.py
ADDED
|
@@ -0,0 +1,179 @@
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 1 |
+
import pandas as pd
|
| 2 |
+
import numpy as np
|
| 3 |
+
from scipy.signal import butter, filtfilt, iirnotch, welch, hilbert
|
| 4 |
+
from scipy.interpolate import interp1d
|
| 5 |
+
import yasa
|
| 6 |
+
import mne
|
| 7 |
+
import antropy as ant
|
| 8 |
+
from sklearn.decomposition import PCA
|
| 9 |
+
from hmmlearn.hmm import GaussianHMM
|
| 10 |
+
from sklearn.preprocessing import StandardScaler
|
| 11 |
+
import logging
|
| 12 |
+
import os
|
| 13 |
+
|
| 14 |
+
# Configure logger
|
| 15 |
+
logging.basicConfig(
|
| 16 |
+
level=logging.INFO,
|
| 17 |
+
format='%(asctime)s - %(levelname)s - %(message)s',
|
| 18 |
+
handlers=[
|
| 19 |
+
logging.FileHandler('neuronap.log'),
|
| 20 |
+
logging.StreamHandler()
|
| 21 |
+
]
|
| 22 |
+
)
|
| 23 |
+
logger = logging.getLogger(__name__)
|
| 24 |
+
|
| 25 |
+
def butter_bandpass(lowcut, highcut, fs, order=2):
|
| 26 |
+
nyquist = 0.5 * fs
|
| 27 |
+
low = lowcut / nyquist
|
| 28 |
+
high = highcut / nyquist
|
| 29 |
+
b, a = butter(order, [low, high], btype='band')
|
| 30 |
+
logger.info(f"Created bandpass filter: {lowcut}-{highcut} Hz, order={order}")
|
| 31 |
+
return b, a
|
| 32 |
+
|
| 33 |
+
def detect_spindles(epoch, fs, low=12, high=16, threshold=1.0, min_duration=0.3):
|
| 34 |
+
b, a = butter(4, [low/(fs/2), high/(fs/2)], btype='band')
|
| 35 |
+
sig = filtfilt(b, a, epoch)
|
| 36 |
+
env = np.abs(hilbert(sig))
|
| 37 |
+
thresh_val = np.mean(env) + threshold * np.std(env)
|
| 38 |
+
mask = env > thresh_val
|
| 39 |
+
spindle_times = []
|
| 40 |
+
in_spindle = False
|
| 41 |
+
start = 0
|
| 42 |
+
for i, val in enumerate(mask):
|
| 43 |
+
if val and not in_spindle:
|
| 44 |
+
start = i
|
| 45 |
+
in_spindle = True
|
| 46 |
+
elif not val and in_spindle:
|
| 47 |
+
end = i
|
| 48 |
+
if (end - start) / fs >= min_duration:
|
| 49 |
+
spindle_times.append(start)
|
| 50 |
+
in_spindle = False
|
| 51 |
+
logger.info(f"Detected {len(spindle_times)} spindles in epoch")
|
| 52 |
+
return len(spindle_times)
|
| 53 |
+
|
| 54 |
+
def detect_slow_waves(epoch, fs, low=0.5, high=2, threshold=1.0, min_duration=0.2):
|
| 55 |
+
b, a = butter(4, [low/(fs/2), high/(fs/2)], btype='band')
|
| 56 |
+
sig = filtfilt(b, a, epoch)
|
| 57 |
+
amp = np.abs(sig)
|
| 58 |
+
thresh_val = np.mean(amp) + threshold * np.std(amp)
|
| 59 |
+
mask = amp > thresh_val
|
| 60 |
+
slow_wave_times = []
|
| 61 |
+
in_wave = False
|
| 62 |
+
start = 0
|
| 63 |
+
for i, val in enumerate(mask):
|
| 64 |
+
if val and not in_wave:
|
| 65 |
+
start = i
|
| 66 |
+
in_wave = True
|
| 67 |
+
elif not val and in_wave:
|
| 68 |
+
end = i
|
| 69 |
+
if (end - start) / fs >= min_duration:
|
| 70 |
+
slow_wave_times.append(start)
|
| 71 |
+
in_wave = False
|
| 72 |
+
logger.info(f"Detected {len(slow_wave_times)} slow waves in epoch")
|
| 73 |
+
return len(slow_wave_times)
|
| 74 |
+
|
| 75 |
+
def extract_features(epochs, fs):
|
| 76 |
+
logger.info(f"Extracting features from {len(epochs)} epochs")
|
| 77 |
+
features = []
|
| 78 |
+
for ep in epochs:
|
| 79 |
+
f, psd = welch(ep, fs=fs, nperseg=fs*4)
|
| 80 |
+
total_power = np.sum(psd)
|
| 81 |
+
delta = np.sum(psd[(f >= 0.5) & (f < 4)])
|
| 82 |
+
theta = np.sum(psd[(f >= 4) & (f < 8)])
|
| 83 |
+
alpha = np.sum(psd[(f >= 8) & (f < 13)])
|
| 84 |
+
sigma = np.sum(psd[(f >= 12) & (f < 16)])
|
| 85 |
+
beta = np.sum(psd[(f >= 13) & (f < 32)])
|
| 86 |
+
rel_delta = delta / total_power if total_power else 0
|
| 87 |
+
rel_theta = theta / total_power if total_power else 0
|
| 88 |
+
rel_alpha = alpha / total_power if total_power else 0
|
| 89 |
+
rel_sigma = sigma / total_power if total_power else 0
|
| 90 |
+
rel_beta = beta / total_power if total_power else 0
|
| 91 |
+
samp_entropy = ant.sample_entropy(ep)
|
| 92 |
+
spindle_count = detect_spindles(ep, fs)
|
| 93 |
+
slow_wave_count = detect_slow_waves(ep, fs)
|
| 94 |
+
features.append([rel_delta, rel_theta, rel_alpha, rel_sigma, rel_beta, samp_entropy, spindle_count, slow_wave_count])
|
| 95 |
+
feature_names = ['rel_delta', 'rel_theta', 'rel_alpha', 'rel_sigma', 'rel_beta', 'sample_entropy', 'spindle_count', 'slow_wave_count']
|
| 96 |
+
features_df = pd.DataFrame(features, columns=feature_names)
|
| 97 |
+
features_df.to_csv('features.csv', index=False)
|
| 98 |
+
logger.info("Saved features to features.csv")
|
| 99 |
+
return features_df
|
| 100 |
+
|
| 101 |
+
def process_eeg(file_path):
|
| 102 |
+
logger.info(f"Processing EEG file: {file_path}")
|
| 103 |
+
if not os.path.exists(file_path):
|
| 104 |
+
logger.error(f"CSV file not found: {file_path}")
|
| 105 |
+
raise FileNotFoundError(f"CSV file not found: {file_path}")
|
| 106 |
+
df = pd.read_csv(file_path)
|
| 107 |
+
if 'time_ms' not in df.columns or 'adc_value' not in df.columns:
|
| 108 |
+
logger.error("CSV must contain 'time_ms' and 'adc_value' columns")
|
| 109 |
+
raise ValueError("CSV must contain 'time_ms' and 'adc_value' columns")
|
| 110 |
+
adc_values = pd.to_numeric(df['adc_value'], errors='coerce').values
|
| 111 |
+
time_ms = pd.to_numeric(df['time_ms'], errors='coerce').values
|
| 112 |
+
mask = ~np.isnan(adc_values) & ~np.isnan(time_ms)
|
| 113 |
+
adc_values = adc_values[mask]
|
| 114 |
+
time_ms = time_ms[mask]
|
| 115 |
+
logger.info(f"Loaded {len(adc_values)} valid data points")
|
| 116 |
+
v_ref = 3.3
|
| 117 |
+
gain = 15000
|
| 118 |
+
voltage_raw = adc_values * (v_ref / 4095)
|
| 119 |
+
estimated_bias = np.mean(voltage_raw)
|
| 120 |
+
voltage = voltage_raw - estimated_bias
|
| 121 |
+
eeg_uv = voltage * 1e6 / gain
|
| 122 |
+
df_res = pd.DataFrame({'time_ms': time_ms, 'adc_vals': adc_values})
|
| 123 |
+
df_clean = df_res.groupby('time_ms', as_index=False).agg({'adc_vals': 'mean'})
|
| 124 |
+
sample_rate_hz = 256
|
| 125 |
+
delta_ms = 1000 / sample_rate_hz
|
| 126 |
+
min_time = df_clean['time_ms'].min()
|
| 127 |
+
max_time = df_clean['time_ms'].max()
|
| 128 |
+
new_times = np.arange(min_time, max_time + delta_ms, delta_ms)
|
| 129 |
+
interpolator = interp1d(df_clean['time_ms'], df_clean['adc_vals'], kind='linear', fill_value='extrapolate')
|
| 130 |
+
new_adc_vals = interpolator(new_times)
|
| 131 |
+
df_res = pd.DataFrame({'time_ms': new_times, 'adc_vals': new_adc_vals})
|
| 132 |
+
voltage = (df_res['adc_vals'] * (v_ref / 4095)) - estimated_bias
|
| 133 |
+
eeg_uv = voltage * 1e6 / gain
|
| 134 |
+
df_res['time_s'] = df_res['time_ms'] / 1000
|
| 135 |
+
df_res['eeg_uv'] = eeg_uv
|
| 136 |
+
fs = 256.0
|
| 137 |
+
lowcut = 0.5
|
| 138 |
+
highcut = 30.0
|
| 139 |
+
nyquist = 0.5 * fs
|
| 140 |
+
low = lowcut / nyquist
|
| 141 |
+
high = highcut / nyquist
|
| 142 |
+
b, a = butter(2, [low, high], btype='band')
|
| 143 |
+
eeg_uv_bp = filtfilt(b, a, eeg_uv)
|
| 144 |
+
logger.info("Applied bandpass filter (0.5-30 Hz)")
|
| 145 |
+
notch_freq = 50.0
|
| 146 |
+
q = 30.0
|
| 147 |
+
b_notch, a_notch = iirnotch(notch_freq, q, fs)
|
| 148 |
+
eeg_uv_notched = filtfilt(b_notch, a_notch, eeg_uv_bp)
|
| 149 |
+
logger.info("Applied notch filter (50 Hz)")
|
| 150 |
+
clean_eeg = pd.DataFrame({'time_s': df_res['time_s'], 'eeg_uv': eeg_uv, 'eeg_bpf': eeg_uv_bp, 'eeg_notch': eeg_uv_notched})
|
| 151 |
+
clean_eeg.to_csv('clean_eeg.csv', index=False)
|
| 152 |
+
logger.info("Saved clean EEG data to clean_eeg.csv")
|
| 153 |
+
info = mne.create_info(ch_names=['Fz'], sfreq=fs, ch_types=['eeg'])
|
| 154 |
+
raw = mne.io.RawArray(eeg_uv_notched.reshape(1, -1), info)
|
| 155 |
+
sl = yasa.SleepStaging(raw, eeg_name='Fz')
|
| 156 |
+
hypno = sl.predict()
|
| 157 |
+
logger.info("Completed YASA sleep staging")
|
| 158 |
+
epoch_length = int(30 * fs)
|
| 159 |
+
num_epochs = len(eeg_uv_notched) // epoch_length
|
| 160 |
+
epochs = eeg_uv_notched[:num_epochs * epoch_length].reshape(num_epochs, epoch_length)
|
| 161 |
+
features_df = extract_features(epochs, fs)
|
| 162 |
+
scaler = StandardScaler()
|
| 163 |
+
features_scaled = scaler.fit_transform(features_df)
|
| 164 |
+
pca = PCA(n_components=5)
|
| 165 |
+
features_pca = pca.fit_transform(features_scaled)
|
| 166 |
+
logger.info("Applied PCA with 5 components")
|
| 167 |
+
model = GaussianHMM(n_components=5, covariance_type="full", n_iter=2000, tol=1e-6, random_state=42)
|
| 168 |
+
model.fit(features_pca)
|
| 169 |
+
hmm_labels = model.predict(features_pca)
|
| 170 |
+
logger.info("Completed HMM clustering")
|
| 171 |
+
clustered_features = features_df.copy()
|
| 172 |
+
clustered_features['cluster'] = hmm_labels
|
| 173 |
+
clustered_features.to_csv('eeg_clusters.csv', index=False)
|
| 174 |
+
logger.info("Saved clustered features to eeg_clusters.csv")
|
| 175 |
+
hypno_int = yasa.hypno_str_to_int(hypno)
|
| 176 |
+
sf_hyp = 1 / 30
|
| 177 |
+
stats = yasa.sleep_statistics(hypno_int, sf_hyp)
|
| 178 |
+
logger.info("Computed sleep statistics")
|
| 179 |
+
return eeg_uv, eeg_uv_bp, eeg_uv_notched, hypno, stats, features_df, hmm_labels, fs, df_res['time_s'].values
|
rag.py
ADDED
|
@@ -0,0 +1,133 @@
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
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|
|
|
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|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
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|
|
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|
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|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
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|
|
|
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|
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|
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|
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|
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|
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|
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|
|
|
|
|
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|
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|
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|
|
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|
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|
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|
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|
|
|
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|
|
|
|
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|
|
|
|
|
|
|
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|
|
|
|
|
|
|
|
|
|
|
|
|
|
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|
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|
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|
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|
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|
| 1 |
+
import os
|
| 2 |
+
import glob
|
| 3 |
+
from dotenv import load_dotenv
|
| 4 |
+
from langchain_community.document_loaders import PyPDFLoader, TextLoader
|
| 5 |
+
from langchain.text_splitter import RecursiveCharacterTextSplitter
|
| 6 |
+
from langchain_community.vectorstores import FAISS
|
| 7 |
+
from langchain.chains import RetrievalQA
|
| 8 |
+
from langchain.prompts import PromptTemplate
|
| 9 |
+
from langchain_huggingface import HuggingFaceEmbeddings
|
| 10 |
+
from langchain_google_genai import ChatGoogleGenerativeAI
|
| 11 |
+
import logging
|
| 12 |
+
|
| 13 |
+
# Configure logger
|
| 14 |
+
logging.basicConfig(
|
| 15 |
+
level=logging.INFO,
|
| 16 |
+
format='%(asctime)s - %(levelname)s - %(message)s',
|
| 17 |
+
handlers=[
|
| 18 |
+
logging.FileHandler('neuronap.log'),
|
| 19 |
+
logging.StreamHandler()
|
| 20 |
+
]
|
| 21 |
+
)
|
| 22 |
+
logger = logging.getLogger(__name__)
|
| 23 |
+
|
| 24 |
+
load_dotenv()
|
| 25 |
+
os.environ["GOOGLE_API_KEY"] = os.getenv("GEMINI_API_KEY", "")
|
| 26 |
+
if not os.environ["GOOGLE_API_KEY"]:
|
| 27 |
+
logger.error("GEMINI_API_KEY not found in .env file")
|
| 28 |
+
raise ValueError("GEMINI_API_KEY not found in .env file")
|
| 29 |
+
logger.info("Loaded environment variables")
|
| 30 |
+
|
| 31 |
+
# Initialize embeddings and text splitter
|
| 32 |
+
text_splitter = RecursiveCharacterTextSplitter(chunk_size=1000, chunk_overlap=200)
|
| 33 |
+
try:
|
| 34 |
+
embeddings = HuggingFaceEmbeddings(model_name="all-MiniLM-L6-v2")
|
| 35 |
+
logger.info("Initialized sentence-transformers embeddings")
|
| 36 |
+
except Exception as e:
|
| 37 |
+
logger.error(f"Failed to initialize embeddings: {e}")
|
| 38 |
+
raise
|
| 39 |
+
|
| 40 |
+
def create_knowledge_embeddings():
|
| 41 |
+
logger.info("Starting creation of knowledge embeddings")
|
| 42 |
+
knowledge_files = glob.glob("knowledge/*.pdf")
|
| 43 |
+
if not knowledge_files:
|
| 44 |
+
logger.error("No .pdf files found in 'knowledge' folder")
|
| 45 |
+
raise FileNotFoundError("No .pdf files found in 'knowledge' folder.")
|
| 46 |
+
|
| 47 |
+
all_docs = []
|
| 48 |
+
for file_path in knowledge_files:
|
| 49 |
+
try:
|
| 50 |
+
logger.info(f"Loading PDF: {file_path}")
|
| 51 |
+
loader = PyPDFLoader(file_path)
|
| 52 |
+
documents = loader.load()
|
| 53 |
+
texts = text_splitter.split_documents(documents)
|
| 54 |
+
all_docs.extend(texts)
|
| 55 |
+
logger.info(f"Successfully loaded and split {file_path} with {len(texts)} chunks")
|
| 56 |
+
except Exception as e:
|
| 57 |
+
logger.error(f"Error loading {file_path}: {e}")
|
| 58 |
+
|
| 59 |
+
if not all_docs:
|
| 60 |
+
logger.error("No valid documents loaded from knowledge folder")
|
| 61 |
+
raise ValueError("No valid documents loaded from knowledge folder.")
|
| 62 |
+
|
| 63 |
+
logger.info(f"Creating FAISS index with {len(all_docs)} document chunks")
|
| 64 |
+
try:
|
| 65 |
+
vectorstore = FAISS.from_documents(all_docs, embeddings)
|
| 66 |
+
vectorstore.save_local("faiss_index")
|
| 67 |
+
logger.info("FAISS embeddings created and saved to 'faiss_index'")
|
| 68 |
+
except Exception as e:
|
| 69 |
+
logger.error(f"Error creating FAISS index: {e}")
|
| 70 |
+
raise
|
| 71 |
+
|
| 72 |
+
def load_vectorstore():
|
| 73 |
+
logger.info("Loading FAISS vectorstore")
|
| 74 |
+
if not os.path.exists("faiss_index"):
|
| 75 |
+
logger.error("FAISS index not found")
|
| 76 |
+
raise FileNotFoundError("FAISS index not found. Run create_knowledge_embeddings first.")
|
| 77 |
+
vectorstore = FAISS.load_local("faiss_index", embeddings, allow_dangerous_deserialization=True)
|
| 78 |
+
logger.info("FAISS vectorstore loaded successfully")
|
| 79 |
+
return vectorstore
|
| 80 |
+
|
| 81 |
+
def update_vectorstore_with_user_results(user_results):
|
| 82 |
+
logger.info("Updating vectorstore with user results")
|
| 83 |
+
vectorstore = load_vectorstore()
|
| 84 |
+
with open("user_results.txt", "w", encoding="utf-8") as f:
|
| 85 |
+
f.write(user_results)
|
| 86 |
+
user_loader = TextLoader("user_results.txt")
|
| 87 |
+
user_docs = user_loader.load()
|
| 88 |
+
user_texts = text_splitter.split_documents(user_docs)
|
| 89 |
+
vectorstore.add_documents(user_texts)
|
| 90 |
+
vectorstore.save_local("faiss_index")
|
| 91 |
+
logger.info("User results added to vectorstore and saved")
|
| 92 |
+
return vectorstore
|
| 93 |
+
|
| 94 |
+
def setup_rag():
|
| 95 |
+
logger.info("Setting up RAG chain")
|
| 96 |
+
try:
|
| 97 |
+
llm = ChatGoogleGenerativeAI(model="gemini-2.0-flash", temperature=0.5)
|
| 98 |
+
logger.info("Initialized Gemini 2.0 Flash LLM")
|
| 99 |
+
except Exception as e:
|
| 100 |
+
logger.error(f"Error initializing LLM: {e}. Check GEMINI_API_KEY or quota")
|
| 101 |
+
raise
|
| 102 |
+
vectorstore = load_vectorstore()
|
| 103 |
+
prompt_template = """\
|
| 104 |
+
You are an expert assistant in EEG-based sleep analysis. Use the provided context from sleep stage definitions, EEG characteristics, and user-specific results to answer the query.
|
| 105 |
+
Context: {context}
|
| 106 |
+
User Query: {question}
|
| 107 |
+
Provide a clear, educational response in plain text, avoiding Markdown symbols (e.g., **, *). Use bullet points (•) for lists and exact values from user data if referenced. Include concise explanations for each metric or finding.
|
| 108 |
+
"""
|
| 109 |
+
PROMPT = PromptTemplate(template=prompt_template, input_variables=["context", "question"])
|
| 110 |
+
qa_chain = RetrievalQA.from_chain_type(
|
| 111 |
+
llm=llm,
|
| 112 |
+
chain_type="stuff",
|
| 113 |
+
retriever=vectorstore.as_retriever(),
|
| 114 |
+
return_source_documents=True,
|
| 115 |
+
chain_type_kwargs={"prompt": PROMPT}
|
| 116 |
+
)
|
| 117 |
+
logger.info("RAG chain setup completed")
|
| 118 |
+
return qa_chain
|
| 119 |
+
|
| 120 |
+
def chat_with_llm(query, qa_chain):
|
| 121 |
+
logger.info(f"Processing query: {query}")
|
| 122 |
+
try:
|
| 123 |
+
result = qa_chain({"query": query})["result"]
|
| 124 |
+
logger.info("Query processed successfully")
|
| 125 |
+
return result
|
| 126 |
+
except Exception as e:
|
| 127 |
+
logger.error(f"Error processing query: {e}")
|
| 128 |
+
return f"Error processing query: {e}. Check GEMINI_API_KEY or quota"
|
| 129 |
+
|
| 130 |
+
if __name__ == "__main__":
|
| 131 |
+
logger.info("Running rag.py as main script")
|
| 132 |
+
os.makedirs("knowledge", exist_ok=True)
|
| 133 |
+
create_knowledge_embeddings()
|
requirements.txt
ADDED
|
@@ -0,0 +1,20 @@
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|
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|
|
|
| 1 |
+
gradio
|
| 2 |
+
pandas
|
| 3 |
+
numpy
|
| 4 |
+
scipy
|
| 5 |
+
matplotlib
|
| 6 |
+
yasa
|
| 7 |
+
mne
|
| 8 |
+
antropy
|
| 9 |
+
hmmlearn
|
| 10 |
+
scikit-learn
|
| 11 |
+
langchain
|
| 12 |
+
langchain-google-genai
|
| 13 |
+
google-generativeai
|
| 14 |
+
langchain-community
|
| 15 |
+
langchain-huggingface
|
| 16 |
+
faiss-cpu
|
| 17 |
+
python-dotenv
|
| 18 |
+
pillow
|
| 19 |
+
pypdf
|
| 20 |
+
sentence-transformers
|
visuals.py
ADDED
|
@@ -0,0 +1,123 @@
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|
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|
|
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|
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|
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|
|
|
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|
|
|
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|
|
|
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|
|
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|
|
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|
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|
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|
|
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|
|
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|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 1 |
+
import matplotlib.pyplot as plt
|
| 2 |
+
import numpy as np
|
| 3 |
+
import yasa
|
| 4 |
+
import io
|
| 5 |
+
from PIL import Image
|
| 6 |
+
from processing import butter_bandpass, filtfilt
|
| 7 |
+
import logging
|
| 8 |
+
|
| 9 |
+
# Configure logger
|
| 10 |
+
logging.basicConfig(
|
| 11 |
+
level=logging.INFO,
|
| 12 |
+
format='%(asctime)s - %(levelname)s - %(message)s',
|
| 13 |
+
handlers=[
|
| 14 |
+
logging.FileHandler('neuronap.log'),
|
| 15 |
+
logging.StreamHandler()
|
| 16 |
+
]
|
| 17 |
+
)
|
| 18 |
+
logger = logging.getLogger(__name__)
|
| 19 |
+
|
| 20 |
+
def plot_eeg_signals(time_s, eeg_uv, eeg_uv_bp, eeg_uv_notched):
|
| 21 |
+
logger.info("Generating EEG signals plot")
|
| 22 |
+
plt.figure(figsize=(12, 8))
|
| 23 |
+
plt.plot(time_s, eeg_uv, label='Raw EEG (µV)', alpha=0.5)
|
| 24 |
+
plt.plot(time_s, eeg_uv_bp, label='Bandpass EEG (0.5-30 Hz)', linewidth=2)
|
| 25 |
+
plt.plot(time_s, eeg_uv_notched, label='Notched EEG (50 Hz)', linewidth=2, linestyle='--')
|
| 26 |
+
plt.title("EEG Signal: Raw vs Filtered", fontsize=42)
|
| 27 |
+
plt.xlabel("Time (s)", fontsize=36)
|
| 28 |
+
plt.ylabel("Amplitude (µV)", fontsize=36)
|
| 29 |
+
plt.xticks(fontsize=28)
|
| 30 |
+
plt.yticks(fontsize=28)
|
| 31 |
+
plt.grid(True)
|
| 32 |
+
plt.legend(fontsize=18.5, loc='upper right') # Explicit loc to avoid warning
|
| 33 |
+
plt.tight_layout()
|
| 34 |
+
plt.savefig("eeg_signal_plot.pdf", format='pdf', dpi=300)
|
| 35 |
+
logger.info("Saved EEG signals plot to eeg_signal_plot.pdf")
|
| 36 |
+
buf = io.BytesIO()
|
| 37 |
+
plt.savefig(buf, format='png')
|
| 38 |
+
buf.seek(0)
|
| 39 |
+
img = Image.open(buf)
|
| 40 |
+
plt.close()
|
| 41 |
+
return img
|
| 42 |
+
|
| 43 |
+
def plot_frequency_spectra(eeg_uv_notched, fs):
|
| 44 |
+
logger.info("Generating frequency spectra plot")
|
| 45 |
+
from scipy.signal import welch
|
| 46 |
+
f_welch, psd_welch = welch(eeg_uv_notched, fs, nperseg=1024, noverlap=512)
|
| 47 |
+
plt.figure(figsize=(12, 12))
|
| 48 |
+
plt.subplot(2,1,1)
|
| 49 |
+
n = len(eeg_uv_notched)
|
| 50 |
+
freqs_fft = np.fft.fftfreq(n, d=1/fs)
|
| 51 |
+
fft_magnitude = np.abs(np.fft.fft(eeg_uv_notched)) / n
|
| 52 |
+
plt.plot(freqs_fft[:n//2], fft_magnitude[:n//2] * 2, linewidth=2)
|
| 53 |
+
plt.title("FFT Spectrum", fontsize=28)
|
| 54 |
+
plt.xlabel("Frequency (Hz)", fontsize=24)
|
| 55 |
+
plt.ylabel("Magnitude (µV)", fontsize=24)
|
| 56 |
+
plt.grid(True)
|
| 57 |
+
plt.subplot(2,1,2)
|
| 58 |
+
plt.semilogy(f_welch, psd_welch, linewidth=2)
|
| 59 |
+
plt.title("Welch PSD", fontsize=28)
|
| 60 |
+
plt.xlabel("Frequency (Hz)", fontsize=24)
|
| 61 |
+
plt.ylabel("Power/Frequency (µV²/Hz)", fontsize=24)
|
| 62 |
+
plt.grid(True)
|
| 63 |
+
plt.tight_layout()
|
| 64 |
+
plt.savefig("eeg_fft_welch.pdf", format='pdf', dpi=300)
|
| 65 |
+
logger.info("Saved frequency spectra plot to eeg_fft_welch.pdf")
|
| 66 |
+
buf = io.BytesIO()
|
| 67 |
+
plt.savefig(buf, format='png')
|
| 68 |
+
buf.seek(0)
|
| 69 |
+
img = Image.open(buf)
|
| 70 |
+
plt.close()
|
| 71 |
+
return img
|
| 72 |
+
|
| 73 |
+
def plot_band_waveforms(eeg_uv_notched, fs, start_s=3000, end_s=3020):
|
| 74 |
+
logger.info("Generating frequency bands plot")
|
| 75 |
+
time_s = np.arange(len(eeg_uv_notched)) / fs
|
| 76 |
+
mask = (time_s >= start_s) & (time_s <= end_s)
|
| 77 |
+
window = eeg_uv_notched[mask]
|
| 78 |
+
time_window = time_s[mask]
|
| 79 |
+
eeg_delta = filtfilt(*butter_bandpass(0.5, 4, fs), window)
|
| 80 |
+
eeg_theta = filtfilt(*butter_bandpass(4, 8, fs), window)
|
| 81 |
+
eeg_alpha = filtfilt(*butter_bandpass(8, 13, fs), window)
|
| 82 |
+
eeg_beta = filtfilt(*butter_bandpass(13, 30, fs), window)
|
| 83 |
+
plt.figure(figsize=(16, 18))
|
| 84 |
+
plt.subplot(4,1,1); plt.plot(time_window, eeg_delta, linewidth=2); plt.title("Delta (0.5-4 Hz)", fontsize=28)
|
| 85 |
+
plt.subplot(4,1,2); plt.plot(time_window, eeg_theta, linewidth=2); plt.title("Theta (4-8 Hz)", fontsize=28)
|
| 86 |
+
plt.subplot(4,1,3); plt.plot(time_window, eeg_alpha, linewidth=2); plt.title("Alpha (8-13 Hz)", fontsize=28)
|
| 87 |
+
plt.subplot(4,1,4); plt.plot(time_window, eeg_beta, linewidth=2); plt.title("Beta (13-30 Hz)", fontsize=28)
|
| 88 |
+
plt.tight_layout()
|
| 89 |
+
plt.savefig("eeg_bands_plot.pdf", format='pdf', dpi=300)
|
| 90 |
+
logger.info("Saved frequency bands plot to eeg_bands_plot.pdf")
|
| 91 |
+
buf = io.BytesIO()
|
| 92 |
+
plt.savefig(buf, format='png')
|
| 93 |
+
buf.seek(0)
|
| 94 |
+
img = Image.open(buf)
|
| 95 |
+
plt.close()
|
| 96 |
+
return img
|
| 97 |
+
|
| 98 |
+
def plot_hypnogram(hypno):
|
| 99 |
+
logger.info("Generating hypnogram plot")
|
| 100 |
+
hypno_int = yasa.hypno_str_to_int(hypno)
|
| 101 |
+
time_minutes = np.arange(len(hypno_int)) * 0.5
|
| 102 |
+
start_min, end_min = 40, 170
|
| 103 |
+
start_epoch = int(start_min / 0.5)
|
| 104 |
+
end_epoch = int(end_min / 0.5)
|
| 105 |
+
window_time = time_minutes[start_epoch:end_epoch]
|
| 106 |
+
window_hypno = hypno_int[start_epoch:end_epoch]
|
| 107 |
+
plt.figure(figsize=(16, 6))
|
| 108 |
+
plt.step(window_time, window_hypno, where='post', color='navy', linewidth=3)
|
| 109 |
+
plt.gca().invert_yaxis()
|
| 110 |
+
plt.yticks([4, 3, 2, 1, 0], ['W', 'N1', 'N2', 'N3', 'R'], fontsize=28)
|
| 111 |
+
plt.xlabel('Time (minutes)', fontsize=32)
|
| 112 |
+
plt.ylabel('Sleep Stage', fontsize=32)
|
| 113 |
+
plt.title(f'Hypnogram ({start_min}-{end_min} min)', fontsize=36)
|
| 114 |
+
plt.grid(axis='x', linestyle='--', alpha=0.5)
|
| 115 |
+
plt.tight_layout()
|
| 116 |
+
plt.savefig("hypnogram_plot.pdf", format='pdf', dpi=300)
|
| 117 |
+
logger.info("Saved hypnogram to hypnogram_plot.pdf")
|
| 118 |
+
buf = io.BytesIO()
|
| 119 |
+
plt.savefig(buf, format='png')
|
| 120 |
+
buf.seek(0)
|
| 121 |
+
img = Image.open(buf)
|
| 122 |
+
plt.close()
|
| 123 |
+
return img
|