Spaces:
Running on Zero
Running on Zero
Update license to CC BY 4.0; remove obsolete test files and README sections
Browse files- LICENSE +396 -0
- README.md +14 -32
- tests/__init__.py +0 -0
- tests/test_output_parser.py +0 -24
- tests/test_pipeline_mock.py +0 -124
- tests/test_smoke.py +0 -35
LICENSE
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README.md
CHANGED
|
@@ -7,7 +7,7 @@ sdk: gradio
|
|
| 7 |
sdk_version: "5.12.0"
|
| 8 |
app_file: app.py
|
| 9 |
pinned: false
|
| 10 |
-
license:
|
| 11 |
tags:
|
| 12 |
- medgemma
|
| 13 |
- medical-imaging
|
|
@@ -52,9 +52,9 @@ The system runs a **4-agent pipeline** orchestrated by [LangGraph](https://langc
|
|
| 52 |
| Agent | Role | Model | Key Design Choice |
|
| 53 |
|:------|:-----|:------|:------------------|
|
| 54 |
| **Diagnostician** | Independent image + clinical analysis | [MedGemma 4B-IT](https://huggingface.co/google/medgemma-1.5-4b-it) (multimodal) | **Blinded** — never sees the doctor's diagnosis. Tags each finding as `imaging`, `clinical`, or `both` to distinguish evidence sources. |
|
| 55 |
-
| **Bias Detector** | Compare doctor vs. AI findings | [MedGemma](https://huggingface.co/google/medgemma-1.5-4b-it)
|
| 56 |
-
| **Devil's Advocate** | Adversarial challenge | [MedGemma](https://huggingface.co/google/medgemma-
|
| 57 |
-
| **Consultant** | Synthesize final report | [MedGemma](https://huggingface.co/google/medgemma-
|
| 58 |
|
| 59 |
## Architecture
|
| 60 |
|
|
@@ -119,20 +119,13 @@ Three composite clinical scenarios covering the most dangerous diagnostic error
|
|
| 119 |
| Model | Parameters | Role | Loading |
|
| 120 |
|:------|:----------|:-----|:--------|
|
| 121 |
| [MedGemma 1.5 4B-IT](https://huggingface.co/google/medgemma-1.5-4b-it) | 4B | Multimodal image+text analysis | 4-bit quantized (~4GB VRAM) or BF16 (~8GB) |
|
| 122 |
-
| [MedGemma 27B Text-IT](https://huggingface.co/google/medgemma-27b-text-it) | 27B |
|
| 123 |
| [MedSigLIP-448](https://huggingface.co/google/medsiglip-448) | 0.9B | Zero-shot sign verification | FP32 (~3GB VRAM) |
|
| 124 |
| [MedASR](https://huggingface.co/google/medasr) | 105M | Medical speech-to-text | FP32 (~0.5GB VRAM) |
|
| 125 |
|
| 126 |
-
### Hardware
|
| 127 |
|
| 128 |
-
|
| 129 |
-
|:------------|:----|:-------------|:-----------|
|
| 130 |
-
| **Local dev** | RTX 4070 12GB | 4B 4-bit + MedSigLIP + MedASR | ~7.5 GB |
|
| 131 |
-
| **School HPC** | A100 80GB | 4B BF16 + **27B BF16** + MedSigLIP + MedASR | ~66 GB |
|
| 132 |
-
| **HF Space** | T4 16GB | 4B 4-bit + MedSigLIP + MedASR | ~7.5 GB |
|
| 133 |
-
| **Kaggle** | T4 16GB | 4B 4-bit + MedSigLIP | ~7 GB |
|
| 134 |
-
|
| 135 |
-
All models load locally via [Transformers](https://huggingface.co/docs/transformers) with optional [4-bit quantization](https://huggingface.co/docs/bitsandbytes) — **zero API costs, fully offline-capable**.
|
| 136 |
|
| 137 |
### Key Technical Decisions
|
| 138 |
|
|
@@ -144,7 +137,7 @@ All models load locally via [Transformers](https://huggingface.co/docs/transform
|
|
| 144 |
|
| 145 |
- **Thinking token stripping**: MedGemma wraps internal reasoning in `<unused94>...<unused95>` tags ([model card](https://huggingface.co/google/medgemma-27b-text-it#thinking-mode)). These are stripped via regex before display.
|
| 146 |
|
| 147 |
-
- **Adaptive model routing**:
|
| 148 |
|
| 149 |
- **Collegial tone**: The Consultant is prompted to write as a consulting colleague, not a critic. Research shows physicians respond better to [collaborative challenge than confrontation](https://pubmed.ncbi.nlm.nih.gov/28493811/).
|
| 150 |
|
|
@@ -162,7 +155,7 @@ All models load locally via [Transformers](https://huggingface.co/docs/transform
|
|
| 162 |
|
| 163 |
```bash
|
| 164 |
# Clone the repository
|
| 165 |
-
git clone https://
|
| 166 |
cd diagnostic-devils-advocate
|
| 167 |
|
| 168 |
# Install dependencies
|
|
@@ -191,7 +184,7 @@ The app launches at `http://localhost:7860`.
|
|
| 191 |
|
| 192 |
| Variable | Default | Description |
|
| 193 |
|:---------|:--------|:------------|
|
| 194 |
-
| `USE_27B` | `false` | Enable 27B model for
|
| 195 |
| `QUANTIZE_4B` | `true` | 4-bit quantize the 4B model |
|
| 196 |
| `ENABLE_MEDASR` | `true` | Enable voice input via MedASR |
|
| 197 |
| `HF_TOKEN` | — | Hugging Face token (or use `huggingface-cli login`) |
|
|
@@ -211,7 +204,7 @@ diagnostic-devils-advocate/
|
|
| 211 |
│ ├── state.py # LangGraph TypedDict state definitions
|
| 212 |
│ ├── prompts.py # All agent prompt templates
|
| 213 |
│ ├── graph.py # LangGraph StateGraph pipeline
|
| 214 |
-
│ ├── output_parser.py # JSON parsing with json_repair
|
| 215 |
│ ├── diagnostician.py # Agent 1: Blinded image + clinical analysis
|
| 216 |
│ ├── bias_detector.py # Agent 2: Bias detection + MedSigLIP
|
| 217 |
│ ├── devil_advocate.py # Agent 3: Adversarial challenge
|
|
@@ -228,20 +221,9 @@ diagnostic-devils-advocate/
|
|
| 228 |
│ ├── callbacks.py # UI event handlers & pipeline integration
|
| 229 |
│ └── css.py # Custom styling (responsive design)
|
| 230 |
│
|
| 231 |
-
|
| 232 |
-
|
| 233 |
-
|
| 234 |
-
│
|
| 235 |
-
└── tests/
|
| 236 |
-
├── test_smoke.py # Import & build verification
|
| 237 |
-
├── test_output_parser.py # JSON repair tests
|
| 238 |
-
└── test_pipeline_mock.py # Integration tests with mocked models
|
| 239 |
-
```
|
| 240 |
-
|
| 241 |
-
## Testing
|
| 242 |
-
|
| 243 |
-
```bash
|
| 244 |
-
python -m pytest tests/ -v
|
| 245 |
```
|
| 246 |
|
| 247 |
## Disclaimer
|
|
|
|
| 7 |
sdk_version: "5.12.0"
|
| 8 |
app_file: app.py
|
| 9 |
pinned: false
|
| 10 |
+
license: cc-by-4.0
|
| 11 |
tags:
|
| 12 |
- medgemma
|
| 13 |
- medical-imaging
|
|
|
|
| 52 |
| Agent | Role | Model | Key Design Choice |
|
| 53 |
|:------|:-----|:------|:------------------|
|
| 54 |
| **Diagnostician** | Independent image + clinical analysis | [MedGemma 4B-IT](https://huggingface.co/google/medgemma-1.5-4b-it) (multimodal) | **Blinded** — never sees the doctor's diagnosis. Tags each finding as `imaging`, `clinical`, or `both` to distinguish evidence sources. |
|
| 55 |
+
| **Bias Detector** | Compare doctor vs. AI findings | [MedGemma 4B-IT](https://huggingface.co/google/medgemma-1.5-4b-it) + [MedSigLIP](https://huggingface.co/google/medsiglip-448) | Uses **zero-shot image classification** to verify radiological signs. Flags clinical red flags ignored by either assessment. |
|
| 56 |
+
| **Devil's Advocate** | Adversarial challenge | [MedGemma 4B-IT](https://huggingface.co/google/medgemma-1.5-4b-it) | Deliberately contrarian — uses both imaging and clinical evidence to argue for **[must-not-miss diagnoses](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775443/)** |
|
| 57 |
+
| **Consultant** | Synthesize final report | [MedGemma 4B-IT](https://huggingface.co/google/medgemma-1.5-4b-it) or [27B Text-IT](https://huggingface.co/google/medgemma-27b-text-it) | Writes as a **collegial consultant**: *"Have you considered..."* not *"You are wrong."* Only this agent optionally upgrades to 27B for deeper reasoning. |
|
| 58 |
|
| 59 |
## Architecture
|
| 60 |
|
|
|
|
| 119 |
| Model | Parameters | Role | Loading |
|
| 120 |
|:------|:----------|:-----|:--------|
|
| 121 |
| [MedGemma 1.5 4B-IT](https://huggingface.co/google/medgemma-1.5-4b-it) | 4B | Multimodal image+text analysis | 4-bit quantized (~4GB VRAM) or BF16 (~8GB) |
|
| 122 |
+
| [MedGemma 27B Text-IT](https://huggingface.co/google/medgemma-27b-text-it) | 27B | Consultant deep reasoning (optional) | BF16 (~54GB VRAM) |
|
| 123 |
| [MedSigLIP-448](https://huggingface.co/google/medsiglip-448) | 0.9B | Zero-shot sign verification | FP32 (~3GB VRAM) |
|
| 124 |
| [MedASR](https://huggingface.co/google/medasr) | 105M | Medical speech-to-text | FP32 (~0.5GB VRAM) |
|
| 125 |
|
| 126 |
+
### Hardware
|
| 127 |
|
| 128 |
+
The full pipeline (4B 4-bit + MedSigLIP + MedASR) requires **~8 GB VRAM** and runs on any CUDA GPU with 12GB+ memory. All models load locally via [Transformers](https://huggingface.co/docs/transformers) with [4-bit quantization](https://huggingface.co/docs/bitsandbytes) — **zero API costs, fully offline-capable**.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 129 |
|
| 130 |
### Key Technical Decisions
|
| 131 |
|
|
|
|
| 137 |
|
| 138 |
- **Thinking token stripping**: MedGemma wraps internal reasoning in `<unused94>...<unused95>` tags ([model card](https://huggingface.co/google/medgemma-27b-text-it#thinking-mode)). These are stripped via regex before display.
|
| 139 |
|
| 140 |
+
- **Adaptive model routing**: The first three agents (Diagnostician, Bias Detector, Devil's Advocate) always use 4B-IT for multimodal image+text analysis. Only the Consultant (text-only synthesis) optionally upgrades to 27B when `USE_27B=true` for deeper clinical reasoning. `generate_with_image()` always uses 4B (only model with vision).
|
| 141 |
|
| 142 |
- **Collegial tone**: The Consultant is prompted to write as a consulting colleague, not a critic. Research shows physicians respond better to [collaborative challenge than confrontation](https://pubmed.ncbi.nlm.nih.gov/28493811/).
|
| 143 |
|
|
|
|
| 155 |
|
| 156 |
```bash
|
| 157 |
# Clone the repository
|
| 158 |
+
git clone https://github.com/sypsyp97/diagnostic-devils-advocate
|
| 159 |
cd diagnostic-devils-advocate
|
| 160 |
|
| 161 |
# Install dependencies
|
|
|
|
| 184 |
|
| 185 |
| Variable | Default | Description |
|
| 186 |
|:---------|:--------|:------------|
|
| 187 |
+
| `USE_27B` | `false` | Enable 27B model for the Consultant agent |
|
| 188 |
| `QUANTIZE_4B` | `true` | 4-bit quantize the 4B model |
|
| 189 |
| `ENABLE_MEDASR` | `true` | Enable voice input via MedASR |
|
| 190 |
| `HF_TOKEN` | — | Hugging Face token (or use `huggingface-cli login`) |
|
|
|
|
| 204 |
│ ├── state.py # LangGraph TypedDict state definitions
|
| 205 |
│ ├── prompts.py # All agent prompt templates
|
| 206 |
│ ├── graph.py # LangGraph StateGraph pipeline
|
| 207 |
+
│ ├── output_parser.py # JSON parsing with json_repair + llm-output-parser
|
| 208 |
│ ├── diagnostician.py # Agent 1: Blinded image + clinical analysis
|
| 209 |
│ ├── bias_detector.py # Agent 2: Bias detection + MedSigLIP
|
| 210 |
│ ├── devil_advocate.py # Agent 3: Adversarial challenge
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| 221 |
│ ├── callbacks.py # UI event handlers & pipeline integration
|
| 222 |
│ └── css.py # Custom styling (responsive design)
|
| 223 |
│
|
| 224 |
+
└── data/
|
| 225 |
+
└── demo_cases/ # 3 composite clinical scenarios
|
| 226 |
+
└── SOURCES.md # Full literature citations
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| 227 |
```
|
| 228 |
|
| 229 |
## Disclaimer
|
tests/__init__.py
DELETED
|
File without changes
|
tests/test_output_parser.py
DELETED
|
@@ -1,24 +0,0 @@
|
|
| 1 |
-
import sys
|
| 2 |
-
import os
|
| 3 |
-
|
| 4 |
-
sys.path.insert(0, os.path.join(os.path.dirname(__file__), ".."))
|
| 5 |
-
|
| 6 |
-
from agents.output_parser import parse_json_response
|
| 7 |
-
|
| 8 |
-
|
| 9 |
-
def test_parse_json_response_returns_dict():
|
| 10 |
-
parsed = parse_json_response('{"challenges":[{"claim":"x","counter_evidence":"y"}]}')
|
| 11 |
-
assert parsed["challenges"][0]["claim"] == "x"
|
| 12 |
-
|
| 13 |
-
|
| 14 |
-
def test_parse_json_response_coerces_top_level_list_of_strings():
|
| 15 |
-
parsed = parse_json_response('["CT angiogram","D-dimer"]')
|
| 16 |
-
assert parsed["items"] == ["CT angiogram", "D-dimer"]
|
| 17 |
-
|
| 18 |
-
|
| 19 |
-
def test_parse_json_response_infers_container_key_for_da_items():
|
| 20 |
-
parsed = parse_json_response(
|
| 21 |
-
'[{"diagnosis":"Aortic dissection","why_dangerous":"High mortality","supporting_signs":"Pain radiating to back","rule_out_test":"CTA chest"}]'
|
| 22 |
-
)
|
| 23 |
-
assert parsed["must_not_miss"][0]["diagnosis"] == "Aortic dissection"
|
| 24 |
-
|
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|
tests/test_pipeline_mock.py
DELETED
|
@@ -1,124 +0,0 @@
|
|
| 1 |
-
"""End-to-end pipeline test with mocked model calls (no GPU required)."""
|
| 2 |
-
|
| 3 |
-
import os
|
| 4 |
-
import sys
|
| 5 |
-
from unittest.mock import patch
|
| 6 |
-
|
| 7 |
-
from PIL import Image
|
| 8 |
-
|
| 9 |
-
sys.path.insert(0, os.path.join(os.path.dirname(__file__), ".."))
|
| 10 |
-
|
| 11 |
-
|
| 12 |
-
def test_pipeline_end_to_end_with_mocks():
|
| 13 |
-
from agents.graph import run_pipeline
|
| 14 |
-
from agents.prompts import (
|
| 15 |
-
DIAGNOSTICIAN_SYSTEM,
|
| 16 |
-
BIAS_DETECTOR_SYSTEM,
|
| 17 |
-
DEVIL_ADVOCATE_SYSTEM,
|
| 18 |
-
CONSULTANT_SYSTEM,
|
| 19 |
-
)
|
| 20 |
-
|
| 21 |
-
dummy_image = Image.new("RGB", (512, 512), color="gray")
|
| 22 |
-
|
| 23 |
-
diagnostician_json = """
|
| 24 |
-
{
|
| 25 |
-
"findings": [
|
| 26 |
-
{"finding": "Pneumothorax", "source": "imaging", "description": "Left apical pleural line with absent peripheral markings."},
|
| 27 |
-
{"finding": "Rib fracture", "source": "imaging", "description": "Possible fracture of the left 5th rib."},
|
| 28 |
-
{"finding": "Tachycardia", "source": "clinical", "description": "HR 104, consistent with pain or hemodynamic compromise."}
|
| 29 |
-
],
|
| 30 |
-
"differential_diagnoses": [
|
| 31 |
-
{"diagnosis": "Pneumothorax", "reasoning": "Visible pleural line on imaging combined with tachycardia and dyspnea from clinical context."}
|
| 32 |
-
]
|
| 33 |
-
}
|
| 34 |
-
""".strip()
|
| 35 |
-
|
| 36 |
-
bias_detector_json = """
|
| 37 |
-
{
|
| 38 |
-
"discrepancy_summary": "Doctor focused on rib pain; image suggests pneumothorax.",
|
| 39 |
-
"identified_biases": [
|
| 40 |
-
{"type": "Anchoring", "evidence": "Trauma mechanism overweighted", "severity": "HIGH"}
|
| 41 |
-
],
|
| 42 |
-
"missed_findings": ["Pneumothorax"],
|
| 43 |
-
"agreement_points": ["Rib pain consistent with trauma"]
|
| 44 |
-
}
|
| 45 |
-
""".strip()
|
| 46 |
-
|
| 47 |
-
devil_advocate_json = """
|
| 48 |
-
{
|
| 49 |
-
"challenges": [
|
| 50 |
-
{"claim": "Rib contusion explains symptoms", "counter_evidence": "Dyspnea can reflect pneumothorax severity."}
|
| 51 |
-
],
|
| 52 |
-
"must_not_miss": [
|
| 53 |
-
{
|
| 54 |
-
"diagnosis": "Tension pneumothorax",
|
| 55 |
-
"why_dangerous": "Rapid hemodynamic collapse if untreated",
|
| 56 |
-
"supporting_signs": "Worsening dyspnea and pleural line",
|
| 57 |
-
"rule_out_test": "Bedside ultrasound or repeat upright CXR"
|
| 58 |
-
}
|
| 59 |
-
],
|
| 60 |
-
"recommended_workup": ["Repeat upright chest radiograph", "Point-of-care ultrasound"]
|
| 61 |
-
}
|
| 62 |
-
""".strip()
|
| 63 |
-
|
| 64 |
-
consultant_json = """
|
| 65 |
-
{
|
| 66 |
-
"consultation_note": "Have you considered pneumothorax given the pleural line?\\n\\nI would re-image upright and consider bedside ultrasound.",
|
| 67 |
-
"alternative_diagnoses": [
|
| 68 |
-
{
|
| 69 |
-
"diagnosis": "Pneumothorax",
|
| 70 |
-
"urgency": "high",
|
| 71 |
-
"evidence": "Pleural line and absent peripheral markings",
|
| 72 |
-
"next_step": "Repeat upright CXR or POCUS"
|
| 73 |
-
}
|
| 74 |
-
],
|
| 75 |
-
"immediate_actions": ["Repeat upright CXR", "POCUS"],
|
| 76 |
-
"confidence_note": "Based on a single image; clinical correlation required."
|
| 77 |
-
}
|
| 78 |
-
""".strip()
|
| 79 |
-
|
| 80 |
-
def fake_generate_with_image(_prompt: str, _image, system_prompt: str = "") -> str:
|
| 81 |
-
if system_prompt == DIAGNOSTICIAN_SYSTEM:
|
| 82 |
-
return diagnostician_json
|
| 83 |
-
if system_prompt == BIAS_DETECTOR_SYSTEM:
|
| 84 |
-
return bias_detector_json
|
| 85 |
-
if system_prompt.startswith(DEVIL_ADVOCATE_SYSTEM):
|
| 86 |
-
return devil_advocate_json
|
| 87 |
-
raise AssertionError(f"Unexpected system_prompt (with image): {system_prompt!r}")
|
| 88 |
-
|
| 89 |
-
def fake_generate_text(_prompt: str, system_prompt: str = "") -> str:
|
| 90 |
-
if system_prompt == CONSULTANT_SYSTEM:
|
| 91 |
-
return consultant_json
|
| 92 |
-
raise AssertionError(f"Unexpected system_prompt: {system_prompt!r}")
|
| 93 |
-
|
| 94 |
-
with patch("models.medgemma_client.generate_with_image", side_effect=fake_generate_with_image), patch(
|
| 95 |
-
"models.medgemma_client.generate_text",
|
| 96 |
-
side_effect=fake_generate_text,
|
| 97 |
-
), patch(
|
| 98 |
-
"models.medsiglip_client.verify_findings",
|
| 99 |
-
return_value=[{"sign": "pneumothorax", "confidence": "likely present"}],
|
| 100 |
-
):
|
| 101 |
-
result = run_pipeline(
|
| 102 |
-
image=dummy_image,
|
| 103 |
-
doctor_diagnosis="Rib contusion",
|
| 104 |
-
clinical_context="32M, trauma, left chest pain, mild dyspnea.",
|
| 105 |
-
modality="CXR",
|
| 106 |
-
)
|
| 107 |
-
|
| 108 |
-
assert result.get("error") is None
|
| 109 |
-
|
| 110 |
-
diag = result.get("diagnostician_output") or {}
|
| 111 |
-
assert diag.get("findings_list"), "Diagnostician findings_list missing"
|
| 112 |
-
assert diag.get("analysis"), "Diagnostician analysis missing"
|
| 113 |
-
|
| 114 |
-
bias = result.get("bias_detector_output") or {}
|
| 115 |
-
assert bias.get("discrepancy_summary")
|
| 116 |
-
assert bias.get("identified_biases"), "Bias detector identified_biases missing"
|
| 117 |
-
|
| 118 |
-
da = result.get("devils_advocate_output") or {}
|
| 119 |
-
assert da.get("must_not_miss"), "Devil's advocate must_not_miss missing"
|
| 120 |
-
assert all(isinstance(x, str) for x in da.get("recommended_workup", []))
|
| 121 |
-
|
| 122 |
-
ref = result.get("consultant_output") or {}
|
| 123 |
-
assert ref.get("consultation_note")
|
| 124 |
-
assert isinstance(ref.get("alternative_diagnoses"), list)
|
|
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|
tests/test_smoke.py
DELETED
|
@@ -1,35 +0,0 @@
|
|
| 1 |
-
"""Quick smoke tests: imports, graph build, demo loading, utils."""
|
| 2 |
-
|
| 3 |
-
import os
|
| 4 |
-
import sys
|
| 5 |
-
|
| 6 |
-
from PIL import Image
|
| 7 |
-
|
| 8 |
-
sys.path.insert(0, os.path.join(os.path.dirname(__file__), ".."))
|
| 9 |
-
|
| 10 |
-
|
| 11 |
-
def test_smoke_graph_builds():
|
| 12 |
-
from agents.graph import build_graph
|
| 13 |
-
|
| 14 |
-
graph = build_graph()
|
| 15 |
-
assert graph is not None
|
| 16 |
-
|
| 17 |
-
|
| 18 |
-
def test_smoke_demo_loader_returns_expected_shape():
|
| 19 |
-
from ui.callbacks import load_demo
|
| 20 |
-
|
| 21 |
-
img, diagnosis, context, modality = load_demo("Case 1: Missed Pneumothorax")
|
| 22 |
-
assert isinstance(diagnosis, str) and diagnosis
|
| 23 |
-
assert isinstance(context, str) and context
|
| 24 |
-
assert modality in {"CXR", "CT", "Other"}
|
| 25 |
-
assert img is None or hasattr(img, "size")
|
| 26 |
-
|
| 27 |
-
|
| 28 |
-
def test_utils_strip_and_resize():
|
| 29 |
-
from models.utils import resize_for_medgemma, strip_thinking_tokens
|
| 30 |
-
|
| 31 |
-
assert strip_thinking_tokens("<unused94>t<unused95>Real answer") == "Real answer"
|
| 32 |
-
big = Image.new("RGB", (2000, 2000), color="gray")
|
| 33 |
-
resized = resize_for_medgemma(big)
|
| 34 |
-
assert max(resized.size) <= 896
|
| 35 |
-
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