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README.md
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Reference FM weights are pulled from their Hugging Face hubs on first use (UNI / UNI2-h / Virchow2
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are gated — request access on HF beforehand).
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## Intended use & limitations
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**Intended use.** OpenPath is a **frozen feature extractor** for H&E histopathology. It produces a
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Reference FM weights are pulled from their Hugging Face hubs on first use (UNI / UNI2-h / Virchow2
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are gated — request access on HF beforehand).
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### Evaluate your model on AMC-HCC-ST — we run it for you
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AMC-HCC-ST is an in-house, **contamination-free** spatial-transcriptomics cohort that we are actively
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**curating and expanding** at Asan Medical Center. Because it is patient-derived, the cohort **cannot
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be publicly redistributed**. Rather than keep it as an internal-only benchmark, **we offer to run the
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evaluation on your behalf** — send us your pathology encoder and we return its AMC-HCC-ST score under
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the exact protocol used above (leave-one-patient-out ridge, top-50 HVG, mean Pearson), directly
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comparable to the reference models.
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**What to send**
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- **Weights** — a `teacher_checkpoint.pth` / `state_dict`, or a public Hugging Face / `timm` hub id.
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- **A loader** — a small `build()` returning an `nn.Module` that maps a normalized `(B, 3, 224, 224)`
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batch to a `(B, d)` tile embedding (CLS or pooled), plus the expected input normalization
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(ImageNet by default). See `eval/openpath_eva_backbone.py` for the exact interface we use.
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- **Optional** — a one-line model description and license so we can report your result correctly.
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Every submission runs through the same single backbone-factory + probing pipeline (`eval/`), so your
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numbers are apples-to-apples with the table above. This keeps the benchmark **leakage-controlled and
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open to the community** even though the underlying data stays private.
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**Contact:** open a discussion on the [`taejoon89/openpath`](https://huggingface.co/taejoon89/openpath)
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model repo, or email the authors *(TODO: add contact address)*.
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## Intended use & limitations
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**Intended use.** OpenPath is a **frozen feature extractor** for H&E histopathology. It produces a
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