File size: 10,235 Bytes
4d12519
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
# Copyright (c) Microsoft Corporation.
# Licensed under the MIT License.
import json
import random
import torch
import os
import numpy as np
from pytorch_lightning import LightningDataModule
from torch.utils.data import DataLoader, Dataset
from data_provider.gal_helpers import escape_custom_split_sequence
from pathlib import Path
from torch.utils.data.dataloader import default_collate


class ProteinChatCollater(object):
    def __init__(self, tokenizer, q_max_len, a_max_len, use_gal):
        self.tokenizer = tokenizer
        self.q_max_len = q_max_len
        self.a_max_len = a_max_len
        self.use_gal = use_gal
        
    def __call__(self, batch):
        embeds, prot_seqs, questions, answers, q_types = zip(*batch)
        max_embed_len = 896
        ## concate 
        if False:
            max_dim = max([e.shape[0] for e in embeds])

            padded_embeds = []
            for embed in embeds:
                shape_dim0 = embed.shape[0]
                pad1 = ((0, max_dim - shape_dim0), (0, 0), (0, 0))
                padded_embeds.append(np.pad(embed, pad1, mode='constant'))
            padded_embeds = default_collate(padded_embeds).squeeze(dim=2)[:,:1024,:]
        else:
            padded_embeds = torch.zeros(len(embeds), max_embed_len, 512)
            for i in range(len(embeds)):
                padded_embeds[i, :embeds[i].shape[0], :] = embeds[i][:max_embed_len, :]
            padded_embeds = padded_embeds.detach()

        assert len(prot_seqs) == len(questions) == len(answers)

        if self.use_gal:
            questions = [escape_custom_split_sequence(q) for q in questions]
        answers = [a + '\n' for a in answers]
        self.tokenizer.padding_side = 'left'
        q_batch = self.tokenizer(questions,
                                 truncation=True,
                                 padding='max_length',
                                 add_special_tokens=True,
                                 max_length=self.q_max_len,
                                 return_tensors='pt',
                                 return_attention_mask=True, 
                                 return_token_type_ids=False)
        self.tokenizer.padding_side = 'right'
        a_batch = self.tokenizer(answers,
                                 truncation=True,
                                 padding='max_length',
                                 add_special_tokens=True,
                                 max_length=self.a_max_len,
                                 return_tensors='pt',
                                 return_attention_mask=True, 
                                 return_token_type_ids=False)
        prot_mask = torch.ones(padded_embeds.shape[0], padded_embeds.shape[1], dtype=torch.bool)
        return (padded_embeds, prot_mask), q_batch, a_batch


class InferenceCollater(object):
    def __init__(self, tokenizer, q_max_len, a_max_len, use_gal):
        self.tokenizer = tokenizer
        self.q_max_len = q_max_len
        self.a_max_len = a_max_len
        self.use_gal = use_gal
        
    def __call__(self, batch):
        embeds, prot_seqs, questions, answers, q_types = zip(*batch)
        max_embed_len = 896
        ## concate 
        if False:
            max_dim = max([e.shape[0] for e in embeds])

            padded_embeds = []
            for embed in embeds:
                shape_dim0 = embed.shape[0]
                pad1 = ((0, max_dim - shape_dim0), (0, 0), (0, 0))
                padded_embeds.append(np.pad(embed, pad1, mode='constant'))
            padded_embeds = default_collate(padded_embeds).squeeze(dim=2)[:,:1024,:]
        else:
            padded_embeds = torch.zeros(len(embeds), max_embed_len, 512)
            for i in range(len(embeds)):
                padded_embeds[i, :embeds[i].shape[0], :] = embeds[i][:max_embed_len, :]
            padded_embeds = padded_embeds.detach()

        assert len(prot_seqs) == len(questions) == len(answers)

        if self.use_gal:
            questions = [escape_custom_split_sequence(q) for q in questions]
        answers = [a + '\n' for a in answers]
        self.tokenizer.padding_side = 'left'
        q_batch = self.tokenizer(questions,
                                 truncation=True,
                                 padding='max_length',
                                 add_special_tokens=True,
                                 max_length=self.q_max_len,
                                 return_tensors='pt',
                                 return_attention_mask=True, 
                                 return_token_type_ids=False)
        prot_mask = torch.ones(padded_embeds.shape[0], padded_embeds.shape[1], dtype=torch.bool)
        target_dict = {'answers': answers, "q_types": q_types}
        return (padded_embeds, prot_mask), q_batch, target_dict


class ProteinChatDM(LightningDataModule):
    def __init__(
        self,
        root: str = 'data/',
        args=None,
    ):
        super().__init__()
        self.args = args
        self.batch_size = args.batch_size
        self.inference_batch_size = args.inference_batch_size
        self.num_workers = args.num_workers
        self.q_max_len = args.q_max_len
        self.a_max_len = args.a_max_len
        self.prompt = args.prompt
        
        self.train_dataset = ProteinChatDataset(root, 'train.txt', prompt="### Human: {}\n### Assistant: ", pt_file_path=args.pt_file_path)
        self.val_dataset = ProteinChatDataset(root, 'val.txt', prompt="### Human: {}\n### Assistant: ", pt_file_path=args.pt_file_path)
        self.test_dataset = ProteinChatDataset(root, 'test.txt', prompt="### Human: {}\n### Assistant: ", pt_file_path=args.pt_file_path)
        
        self.tokenizer = None
        self.use_gal = args.llm_name.find('gal') >= 0
    
    def init_tokenizer(self, tokenizer):
        self.tokenizer = tokenizer

    def train_dataloader(self):
        loader = DataLoader(
            self.train_dataset,
            batch_size=self.batch_size,
            shuffle=True,
            num_workers=self.num_workers,
            pin_memory=False,
            drop_last=True,
            persistent_workers=False,
            collate_fn=ProteinChatCollater(self.tokenizer, self.q_max_len, self.a_max_len, self.use_gal),
        )
        return loader

    def val_dataloader(self):
        val_loader = DataLoader(
            self.val_dataset,
            batch_size=self.batch_size,
            shuffle=False,
            num_workers=self.num_workers,
            pin_memory=False,
            drop_last=False,
            persistent_workers=False,
            collate_fn=ProteinChatCollater(self.tokenizer, self.q_max_len, self.a_max_len, self.use_gal),
        )
        test_loader = DataLoader(
            self.test_dataset,
            batch_size=self.inference_batch_size,
            shuffle=False,
            num_workers=self.num_workers,
            pin_memory=False,
            drop_last=False,
            persistent_workers=False,
            collate_fn=InferenceCollater(self.tokenizer, self.q_max_len, self.a_max_len, self.use_gal),
        )
        return [val_loader, test_loader]
    

    def add_model_specific_args(parent_parser):
        parser = parent_parser.add_argument_group("Data module")
        parser.add_argument('--num_workers', type=int, default=2)
        parser.add_argument('--batch_size', type=int, default=32)
        parser.add_argument('--inference_batch_size', type=int, default=4)
        parser.add_argument('--root', type=str, default='data/SwissProtV3')
        parser.add_argument('--q_max_len', type=int, default=30)
        parser.add_argument('--a_max_len', type=int, default=36)
        parser.add_argument('--prompt', type=str, default='[START_AMINO]{}[END_AMINO]. Question: {} Answer:')
        parser.add_argument('--pt_file_path', type=str, default='/home/XXXX-2/proteinchatdata/proteinchat')
        return parent_parser



class ProteinChatDataset(Dataset):
    def __init__(self, root_path, subset, pt_file_path, prompt="Question: {} Answer:"):
        super(ProteinChatDataset, self).__init__()
        self.data_path = Path(root_path) / subset
        self.qa_path = Path(root_path) / 'qa_all.json'
        self.q_type_path = Path(root_path) / 'q_types.txt'
        self.prompt = prompt

        ## load dataset
        with open(self.qa_path, 'r') as f:
            qa_data = json.load(f)
        
        with open(self.data_path, 'r') as f:
            lines = f.readlines()
            pdb2seq = [line.strip().split('\t') for line in lines]
        
        ## process dataset
        pdb_set = set(i[0] for i in pdb2seq)
        ## filter qa data
        qa_data = {k: v for k, v in qa_data.items() if k in pdb_set}
        assert len(qa_data) == len(pdb_set), print(len(qa_data), len(pdb_set))
        
        pt_file = Path(pt_file_path).glob('*.pt')
        pt_file_ids = {f.name.split('.pt')[0] for f in pt_file}
        self.pt_file_path = pt_file_path

        ## load q types
        with open(self.q_type_path, 'r') as f:
            q_types = [line.strip().split('\t') for line in f.readlines()]
        self.q_type_dict = {q: t for q, t in q_types}

        ## generate qa data
        self.data_list = []
        for pdb_id, seq in pdb2seq:
            if pdb_id not in pt_file_ids:
                continue
            qa_list = qa_data[pdb_id]
            for qa in qa_list:
                q = qa['Q']
                a = str(qa['A'])
                self.data_list.append((pdb_id, seq, q, a))

    def shuffle(self):
        random.shuffle(self.data_list)
        return self

    def __len__(self):
        return len(self.data_list)

    def __getitem__(self, index):
        pdb_id, seq, q, a = self.data_list[index]
        q_type = self.q_type_dict[q]
        path = os.path.join(self.pt_file_path, pdb_id + '.pt')
        embed = torch.load(path, map_location=torch.device('cpu'))
        embed = embed.squeeze(dim=1)
        embed = embed.detach()
        q = self.prompt.format(q)
        return embed, seq, q, a, q_type


if __name__ == '__main__':
    dataset = ProteinChatDataset('./data/PDBDataset', 'train.txt')
    dataset.shuffle()
    for i in range(1000):
        print(dataset[i][0].shape)