Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIKTTNPVATEQYGSVSTNLVRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -2.368229627609253


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIKTTNPVATEQYGTVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -1.194144606590271


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIKTTNPVATEQYGVVPEDLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 3.184677124023437


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIKTTNPVATEQYVSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -3.809267282485962


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIKTTNMPVATEQYGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -5.4820237159729


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIKTVNPVATEQYGSISENLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.8092288970947266


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEILATNPVATEQYGSVSTGLQRSNFQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.2319501787424087


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEILTTNPHATEQYGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -4.265169143676758


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEILTTNPVATEQYGSVSTNLQRGNREQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.0059071420691907


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEILTTNPVATWQYGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -5.648573398590088


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEILTTNPVASTEQYGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -4.493927478790283


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEILTVNPVATEQYGSVYSTNLDQTGENRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -2.6240828037261963


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIMCTNPVCTEQYGSVSTDVQRGNLQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -2.350468635559082


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIMGTNPVATEQYGSVSENLQRGNIQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -1.0419100522994995


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIMSVNPVATEQYGSVSCNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -1.8677518367767327


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIMTTNPDATEQYGNVNSTNLQRGNPQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -3.7009356021881104


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIMTTNPTASEQYGSVATNLQQGNAQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.5554071068763733


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIMTTNPVASEQYGAVSTALQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -2.469874858856201


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIMTTNPVATDQYGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -2.9226725101470947


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIMTTNPVATEMYGSVSTNLQNGNQQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.5443397760391235


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIMTTNPVATEQYGCVSATNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -1.6218757629394531


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIMTTNPVATEQYGGVSTNLQRGNVQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.6298907399177551


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIMTTNPVATEQYGSVGTNLQDGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.8988805413246155


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIMTTNPVATEQYGSVSTELQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.2198970317840576


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIMTTNPVATEQYGSVSTNLERGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.2882879078388214


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIMTTNPVATEQYGSVSTNLLRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -3.256477832794189


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIMTTNPVATEQYGSVSTNELQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -5.029083728790283


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIMTTNPVATEQYGSVSTINLALSKGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -2.3812575340271


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIMTTNPVATEQYGSVSETNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -1.4257651567459106


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIMTTNPVATEQYGSVCSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -3.600581169128418


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIMTTNPVATEQYGSVMSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -4.792599678039551


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIMTTNPVATEQYGGDVSTNGLQCRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -6.625265121459961


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIMTTNPVCTEQYGGVSTNVQRGNFQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -5.1135430335998535


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIMTTNPVGTEQYGSVSTNLQLGNQQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.9278074502944946


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIMTTNPVSTEQYGSVSTNLQRGLRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -1.8717098236083984


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIMTTNPVSTEQYGSVSTNLQRGNHRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -3.762258768081665


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIMTTVPVATEQYGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -5.580592155456543


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIMTVNPVCTEQYGSVSTNLQRGPRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -3.824630498886109


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEINATNPVATEQFGWVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -1.1022170782089231


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEINATNPVATEQYGVVGTNLQRGGHQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.4270707368850708


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEINSVNPVATEQYGTVSTNLQHAGMRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.2252500504255294


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEINTTNPHATEQYGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.909863829612732


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEINTTNPVATEQYGEVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 2.789613723754883


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEINTTNPVATEQYGEVSTNLQRPNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 3.96994948387146


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEINTTNPVATEQYGSVQTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -3.1299374103546143


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEINTTNPVATEQYGSVSCNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -1.5256032943725586


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEINTTNPVATEQYGSVSNNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.178778052330017


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEINTTNPVATEQYGSVSTNLQRGVNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.7518755197525024


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEINTTNPVATEQYGSVSTNLQRHNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -2.8748209476470947


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEINTTNPVATEQYGSVSTNLQRNGEAQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.0972579419612884


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEINTTNPVATEQYGSVSTNLQRNGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.1909468024969101


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEINTTNPVATEQYGVVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.6975468993186951


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEINTTNPVATEWYGSVSDNLQRGNQQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 3.2950682640075684


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEINTTNPVATQQYGWSVDTNLQDRNNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -4.007565498352051


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEINTTNPVATGEQYGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -4.298032283782959


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEINTTQNPVATEQYGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -5.383341312408447


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIPTTNPVATEQYGSVSTNAQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -5.67277717590332


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIPTTNPVATEQYGSVSTNLQRSGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -5.46987771987915


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIPTTNPVATEQYGSVSTNLEQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -5.878673076629639


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIPTTNPVATEQYGSVSTNLLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -4.350708484649658


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIPTTNPVATEQYGFSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -5.392669200897217


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIPTTNPTVATEQYGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -6.088712215423584


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIPTTNQVATEWYGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -5.102626800537109