Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPTATEQYGSVSTNEQQGNFQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.1233786419034004


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPTATEQYGSVSTNEQQGNGQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.6878640055656433


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPTATEQYGSVSTNEQQGNQQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.2055182456970217


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPTATEQYGSVSTNEQQGNVQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.6782712340354919


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPTATEQYGSVSTNLQIGNAQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.8053507804870605


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPTATEQYGSVSTNLQNGDNLQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.1471648663282394


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPTATEQYGSVSTNLQQGDNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.0448213815689087


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPTATEQYGSVSTNLQDNEGDNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.4083202183246612


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPTATEQYGSVSTNLYRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -1.4644935131072998


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPTATEQYGSVSTNPQIGNAQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.746677577495575


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPTATEQYGSVSTNPQNGNVQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.0654195547103882


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPTATEQYGSVSTNPQQGNFQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.5349059104919434


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPTATEQYGSVSTGNPQLQEGDNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.2839764356613159


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPTATEQYGSVSTMNEQIEGDNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.3763264119625091


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPTATEQYGSVSTMNEQNGDNVQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.3446947634220123


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPTATEQYGSVSTMNEQDRGDNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.6258538365364075


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPTATEQYGSVSTMNEQLNEGDNVQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.3799405992031097


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPTATEVYGGVDTNQQRGPYFQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -2.7869207859039307


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVADEQYGSVSTNLQRGNKQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.234952688217163


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVASECYGSVSTELEQGNIQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.5198513269424438


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATECYGSVSENLQGGNDQQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.762933611869812


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATECYGSVSTDLEDRGELQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.6097016334533691


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATECYGSVSTDLQQGENQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 2.002036094665528


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATECYGSVSTDLQRGNIQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.8287526369094849


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATECYGSVSTNLEHGNLQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.5417200922966003


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATECYGSVSTNLEQGERQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.6632707715034485


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATECYGSVSTNLERGNDLQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.7077296376228333


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATECYGSVSTNLETGDNIQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.4975152909755707


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATECYGSVSTNLQHGERQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 3.211390256881714


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATECYGSVSTNLQHGNDQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.0990397930145264


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATECYGSVSTNLQHGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 2.636061191558838


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATECYGSVSTNLQHNGNQQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 2.873059034347534


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATECYGSVSTNLQRGNIQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 5.131046295166016


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATECYGSVSTNLQRGNNQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 4.3900885581970215


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATECYGSVSTNLQSGEIQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.4350442588329315


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATECYGSVSTNLQDRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 3.0230519771575928


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATECYGSVSTNLQEHEGEEDLQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.0700783506035804


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATECYGSVSTNLQIRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.0563267469406128


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATECYGSVSATDLEINGEDLQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.4319043755531311


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATECYGSVSATDLQREGNDQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.0876015722751617


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATECYGSVSATDLQDHEGEDLQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.5451655983924866


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATECYGVVSTDLQRGEAQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.6677950024604797


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATECYGWVSTNLQRKGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -2.0078601837158203


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATECHYGDASCEEEWIHAEEDIQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.7452278137207031


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATEHYGGVATNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.5018692016601562


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATEIYGSVISTNLQIGINDRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.2889415621757507


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATELYGIVSDDLQQYANGNIQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -1.7512553930282593


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATELYGSVSDDLQYANGNIQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.9867398738861084


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATELYGSVSNDLQRGNTIQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.4248296022415161


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATELYGSVSTNVQWENRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.9020370244979856


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATEMFGSASAENLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.414296954870224


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATEMYGEVSTNLQMGNFQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.5413751602172852


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATEMYGFVATVLCAEERQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -3.5620810985565186


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATEMYGGVSENPQRGTRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.3025091588497162


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATEMYGGVSTNLQQGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 2.7007195949554443


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATEMYGSMSDNLQVGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -2.2758049964904785


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATEMYGSVSEGNLQDRGNDRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.1768535375595093


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATEMYGVVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.6411585807800293


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATENYGDVGENLMHFQNQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -4.355772972106934


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATEQFGGVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.919755220413208


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATEQFGSVSTALQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 2.1531057357788086


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATEQFGWVATNLMRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.6768571138381958


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIATTNPVATEQSGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.0514218024909496