Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEMYGWVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.043350100517273


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATENYGSVGTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.0546746812760829


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQFGSVEAGLYRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -1.6135683059692385


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQFGSVSTNDQNLNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.8111683130264282


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQFGSVSTNLQQGTSQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 2.320228576660156


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQFGSVIPTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -2.093538522720337


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQWGSVSENLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 3.6048080921173096


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGAVGTADQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.4460150003433228


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGDVSTGLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -2.458277702331543


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGDYSENLQQGDRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -1.4798414707183838


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGEVSTLLQRGDQQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.6213977336883545


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGEVSTNEQRGPAQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.6198605298995972


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGGVSTNLERGNFQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.1810320615768433


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGGVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.0619515590369701


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGGVSTNLQRGTRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.2800867557525637


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSASENLQRAGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 3.056402921676636


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSFISTNIPQDRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -2.77052640914917


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVAMNLQGGDRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 4.08954668045044


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVDDVLQEGNIQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -2.7663140296936035


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVDTNLQLGNSQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.8747935891151428


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVGTNLQYGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 2.6016745567321777


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVGTIDLQGGNDRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.4133114516735077


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVPTNVQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.93736469745636


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSADLQGGNGQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.078421711921692


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSANLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.4672581553459167


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSDNLQQGNQQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.4184719324111938


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSEDLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 3.2660536766052246


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSENLQERGDDWQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.9532079696655272


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSEMNPQLIEGDNDFQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.2122363001108169


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSGNLQRGNLQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 3.866650104522705


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSTDLQHGERQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 2.0214340686798096


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSTELELGNPQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.2572481632232666


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSTELQNGELQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.2256675958633425


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSTELQRGERQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.9585723876953125


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSTNEQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 2.843231439590454


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSTNHQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -2.7555105686187744


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSTNLEDGNNQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.2567768096923828


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSTNLQGGNEQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 2.374257326126098


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSTNLQLGNYQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 3.3003225326538086


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSTNLQRGNRSQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -1.4220308065414429


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSTNLQRGNTQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 3.3454885482788086


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSTNLQRGNFRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -1.3972270488739014


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSTNLQRSGDRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 2.3077218532562256


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSTNLQSGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 3.523639440536499


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSTNLQARGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.612926721572876


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSTNLQERGNTQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.2363921403884888


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSTNLPQRGDRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.2212531566619873


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSTNLPQRGTRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.3890145123004913


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSTNLPQRKGINRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -3.059197902679444


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSTNLVQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -1.8754197359085083


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSTNVMRMNAQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 3.385239362716675


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSETENLEREGNPQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.198427438735962


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVSVTMNLQLQGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.615393340587616


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVDSATNLQRGINFQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.4698748886585235


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGSVESTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.8129345178604126


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGTMSTELQSGDRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -2.8521499633789062


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGVVSENLQQGNSQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 2.147292375564575


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGVVSTALQRGNIQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.625326156616211


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGVVSTDLQRGNDDQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.6333032846450806


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGVVSTMNLQDGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.4101274013519287


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYGWVSEDLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.6055796146392822


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQYNGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -5.097213268280029


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIRATNPVATEQSYGSVSTNEQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -3.568466901779175