Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRCTNPVAYEVYGGVSSNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.8540583252906799


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRPTNPVATEQYGSVSTPVQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.5813170671463013


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRQTNPVATEMYGSVSENLDAGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -3.446620464324951


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRQVNPVATEMYGIVSEDLDAGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -6.292294979095459


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRSTNPVATEQWGIVSTALQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.2966288328170776


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRSTNPVATEQYGTMSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -2.2427570819854736


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRSVNPVATEQYGSVSTNLQRLTRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -3.522407054901123


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTCNFVATEQYGSVSTELQRGNQQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -4.36268424987793


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTGPLATEQYGSVSTNLQRGNQQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -4.5902180671691895


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPCASEQYGGASTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -4.687568187713623


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPCATEQYGSVSVMNLCRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -4.2441277503967285


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPCAYEQYGVVASNLERGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.7992550134658811


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPDATEQYGDVSTNLQAGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -2.803487539291382


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPESSEQYGSVSTNEQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -3.07377290725708


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPESSEQYGSVSTPETRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -5.566317081451416


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPIACFVYGSVSDTDLQLPNPNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -4.499224185943604


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPIASEQYGSVSMNLERGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -3.688196420669556


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPIATECYGSVSTNLQVGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 3.4801414012908936


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPIATEHYGSVSTNLQIGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 2.9821839332580566


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPIAYEIYGAVGSNLERNGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.7407789826393127


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPTATEQYGWVSAEEMQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.6778725981712341


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPTATEVYGSVSTDLQRGNDQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.458993911743164


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVACEQYGSCSMNLQQRLNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -4.280012130737305


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVASEMYGGVSTNLQRGNQQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -3.249159812927246


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVASEQYGSVSSNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -1.829813003540039


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVASEQYGSVSTNLQRPNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.5309569835662842


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVASEQYGSVSAMNLQREGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -2.334966897964477


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVASEVYGSVSTDLEDGNEQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -2.1142802238464355


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATECWGSVSENLMRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.7291009426116943


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATECYGSVSAGLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.0875204801559448


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATECYGSVSTNLQQGNDMQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.7784108519554138


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATEIYGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.1348313391208648


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATEMYGAVSTNLDRGDRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.392704039812088


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATEMYGSMSTNLQEAGNNQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.1359784007072448


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATENYGSVSTNYQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -1.1247512102127075


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATEPYGSVSTNQQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.0619243755936622


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATEQCGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -3.538935899734497


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATEQWGSYSTNLQRGNTQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 2.6874043941497803


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATEQYGCVSLNEALRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.3112740516662597


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATEQYGCVSTNLQRGMRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 3.584411144256592


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATEQYGEVSENLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 3.5253257751464844


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATEQYGQVSTNLQREGARQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.8508027791976929


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATEQYGSASTNLQRGPRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.5972999334335327


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATEQYGSCSDNLQRGMRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.2180714309215545


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATEQYGSVATNLQSGDRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.2703005075454712


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATEQYGSVATNLQWGNCQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.6992406845092773


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATEQYGSVATNVQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 2.9921116828918457


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATEQYGSVRTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -5.190284252166748


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATEQYGSVSNNLMRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -1.2947372198104858


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATEQYGSVSTDLEDGNEQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.7454525828361511


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATEQYGSVSTNLGRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -1.1809240579605105


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATEQYGSVSTNLQRGCRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -5.320484638214111


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATEQYGSVSTNLQRGLRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.388654500246048


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATEQYGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.841243326663971


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATEQYGSVSTNTQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -2.92671537399292


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATEQYGSVSTNVQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 3.926952838897705


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATEQYGSVSTNWQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.9381810426712036


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATEQYGSVSTLNLQNGNGQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.355876326560974


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATEQYGSVSWTNLQYRGINRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -2.954362869262696


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVATEQYGSVSYTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -3.266687631607056


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVAYEQYGEVSTALDRGNDQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.703498601913452


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVAYFQYGSVSTNLERGTRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.3823249936103821


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDDEEIRTTNPVGTEGYGSVSSNLQRGDRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 3.5107336044311523