Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIGTTNPPVATEQYGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -4.169355392456055


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIGTVNPVATEQYGNVSENLQRGQRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.8125615119934082


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIHCTNPVAMEQYGWVWTNLQPGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -4.91245174407959


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIHPTNYVATEQYGSVSTNLQRGNDQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -3.632933616638184


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIHTTNPCATEFYGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.1548211723566055


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIHTTNPDATEQYGWVDYNLDLGLAQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -4.75394344329834


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIHTTNPFATEQYIGSVSTDNLVQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -4.221956253051758


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIHTTNPVATEAYGSVSTNLLRGNQQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.199720025062561


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIHTTNPVATEQKGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -4.420390129089356


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIHTTNPVATEQYGDVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.4411222040653229


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIHTTNPVATEQYGSVSTNLCRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -4.11507511138916


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIHTTNPVATEQYGSVSTNLQRGERQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 2.342989444732666


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIHTTNPVATEQYGSVSTNLQRGNDQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 2.313130140304565


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIHTTNPVATEQYGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.6984184384346008


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIHTTNPVATEQYGSVSTNLQRSNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -3.4926066398620605


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIHTTNPVATEQYGSVSTNLLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -4.808080196380615


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIHTTNPVATEQYGSVRSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -5.287261486053467


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIHTTNPVAMTEQYGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -5.850658893585205


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIHTVNRCATLKGYGDVTQTTLQRMGENRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -4.608979225158691


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIHVTNPVATFQYGSVGTPLQRGTRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -4.124326229095459


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIICTNPVATEQYGSVSSCLLNGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -4.166799545288086


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIIGTNPVATEQYGWVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -2.915899515151977


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIIGVNPLGTELFQWVATDAMYIQQCENIQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -6.396131038665772


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIIGVNPLGTELFQWVATDAMYIQQCSESTIQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -6.437607288360596


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIIGVNPLGTELFQWVATDAMYIQQCSESSTIQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -6.501709461212158


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIIPTSPVATEQYGSVADNLQRYNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -5.105084896087647


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIIQTNPCAGEGYGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -4.897685050964356


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIIQTNPVATEQYGSVATNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -2.59185528755188


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIITTNPAATEQYGTVSTNDQLGNFQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -2.491626739501953


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIITTNPVATEQYGEDITNLQRGNAQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -4.323461532592773


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIITTNPVATEQYGEVSTNLQFGTFQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.7319168448448181


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIITTNPVATEQYGFVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -4.0008931159973145


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIITTNPVATEQYGLVWTNLECRGLRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -4.986739635467529


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIITTNPVATEQYGSVSENLQCGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -1.1324046850204468


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIITTNPVATEQYGSVSTDLQEGDAQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.5485618114471436


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIITTNPVATEQYGSVSTNLQREERQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.2266830205917358


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIITTNPVATEQYGSVSTPLQGGESQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.403436541557312


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIITTNPVATEQYGSVSVNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -2.5625431537628174


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIITTNPVATEQYGSVVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -3.4827446937561035


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIITTNPVATEQYGVVSTNGLQERGNWQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -1.3427305221557615


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIITTNPVATEQYGESVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -3.0441243648529053


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIITTNPVATEQYVSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -5.566586971282959


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIITTNPVATEWFGSVSENLQRAGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -2.208180427551269


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIITTNPVATLQYGNVPENLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -3.474133253097534


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIITTNPVSTEQYGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -3.106551170349121


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIITTNPVSTEQYGSVSATNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -2.8377625942230225


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIITTNPVRATEQYGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -6.264176845550537


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIKATNPVATEQWGSVSTNLQRGNFQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 3.958685159683228


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIKCTNPVSTEQYGSVPTNLQRLQRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.3950565755367279


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIKGTNPVATEQYGQVSSNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.6123087406158447


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIKTTNDVATEQYGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -5.8050618171691895


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIKTTNPCATEQYGSVSTNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.1934810131788253


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIKTTNPVATEQYGDTGENLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.8844382762908936


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIKTTNPVATEQYGSVSDLDERGNWQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 0.4705707132816314


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIKTTNPVATEQYGSVSDNLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 2.944485902786255


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIKTTNPVATEQYGSVSENLQHGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 3.742174625396729


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIKTTNPVATEQYGSVSENLQRGGRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 4.589895248413086


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIKTTNPVATEQYGSVSENLQRGNHQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 4.600165843963623


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIKTTNPVATEQYGSVSENLQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 4.887967109680176


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIKTTNPVATEQYGSVSTNEQRGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 1.0331038236618042


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIKTTNPVATEQYGSVSTNLQRGNCRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -3.696675539016724


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIKTTNPVATEQYGSVSTNLQRGNERQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: -0.0793083012104034


Question: Adeno-associated virus (AAV) capsid proteins are essential for delivering DNA payloads into target cells, a property widely exploited in gene therapy. Mutations in a specific 28-amino acid region (positions 561–588 of VP-1, UniProt ID: P03135) can alter the capsid’s ability to package DNA and infect cells. The fitness of a given AAV variant reflects its ability to successfully assemble and deliver its genetic cargo. In this task, given a full AAV capsid protein sequence MAADGYLPDWLEDTLSEGIRQWWKLKPGPPPPKPAERHKDDSRGLVLPGYKYLGPFNGLDKGEPVNEADAAALEHDKAYDRQLDSGDNPYLKYNHADAEFQERLKEDTSFGGNLGRAVFQAKKRVLEPLGLVEEPVKTAPGKKRPVEHSPVEPDSSSGTGKAGQQPARKRLNFGQTGDADSVPDPQPLGQPPAAPSGLGTNTMATGSGAPMADNNEGADGVGNSSGNWHCDSTWMGDRVITTSTRTWALPTYNNHLYKQISSQSGASNDNHYFGYSTPWGYFDFNRFHCHFSPRDWQRLINNNWGFRPKRLNFKLFNIQVKEVTQNDGTTTIANNLTSTVQVFTDSEYQLPYVLGSAHQGCLPPFPADVFMVPQYGYLTLNNGSQAVGRSSFYCLEYFPSQMLRTGNNFTFSYTFEDVPFHSSYAHSQSLDRLMNPLIDQYLYYLSRTNTPSGTTTQSRLQFSQAGASDIRDQSRNWLPGPCYRQQRVSKTSADNNNSEYSWTGATKYHLNGRDSLVNPGPAMASHKDDEEKFFPQSGVLIFGKQGSEKTNVDIEKVMITDEEEIKTTNPVATEQYGSVSTNLQERGNRQAATADVNTQGVLPGMVWQDRDVYLQGPIWAKIPHTDGHFHPSPLMGGFGLKHPPPQILIKNTPVPANPSTTFSAAKFASFITQYSTGQVSVEIEWELQKENSKRWNPEIQYTSNYNKSVNVDFTVDTNGVYSEPRPIGTRYLTRNL with mutations restricted to positions 561–588, predict the fitness score of the variant. The fitness score ranges from 0 (non-functional) to 1 (wild-type level functional performance).What is the predicted fitness score for this AAV variant, representing its ability to package and deliver DNA? <answer>fitness score</answer>

Answer: 4.054732799530029