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EXAONE-Path-CRCMSI-Predictor

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@@ -7,15 +7,16 @@ tags:
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  - EXAONEPath-1.5
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  - pathology
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  ---
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- # EXAONE Path for CRCMSI – CRCMSI-centric Whole-Slide Image Classifier
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- *A purpose-built upgrade of **EXAONE Path 1.5***
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  ## Introduction
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- **EXAONE Path for CRCMSI** is an **enhanced whole-slide image (WSI) classification framework** that retains the core architecture of EXAONE Path 1.5 while upgrading its internals for greater efficiency and richer multimodal integration.
 
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  The pipeline still unfolds in two stages:
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- 1. **Patch-wise feature extraction** – Each WSI is tiled into 256 × 256 px patches, which are embedded into 768-dimensional vectors using the frozen **[EXAONE Path v1.0](https://huggingface.co/LGAI-EXAONE/EXAONEPath)** encoder.
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  2. **Slide-level aggregation** – The patch embeddings are aggregated using a Vision Transformer, producing a unified slide-level representation that a lightweight classification head transforms into task-specific probabilities.
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  ---
@@ -69,19 +70,19 @@ python inference.py --svs_path ./samples/wsis/1/1.svs
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  ### Model Performance Comparison
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- | Metric (AUC) / Task | Titan (Conch v1.5 + iBot, image-text) | PRISM (virchow + perceiver, image-text) | CHIEF (CTransPath + CLAM, image-text, WSI-contrastive) | Prov-GigaPath (GigaPath + LongNet, image-only, mask-prediction) | UNI2-h + CLAM (image-only) | EXAONEPath V1.5 | **{MODEL_NAME}** |
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- |------------------------------------|---------------------------------------|-----------------------------------------|--------------------------------------------------------|-----------------------------------------------------------------|---------------------------|------------------------|------------------------|
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- | **CRC-MSI** | 0.9370 | 0.9432 | 0.9273 | 0.9541 | <u>0.9808</u> | 0.9537 | **0.9844** |
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- | LUAD-TMB (cutoff 10) | 0.6901 | 0.6445 | 0.6501 | 0.6744 | 0.6686 | 0.6846 | 0.6842 |
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- | LUAD-EGFR-mut | 0.8197 | 0.8152 | 0.7691 | 0.7623 | 0.8577 | 0.7607 | 0.8564 |
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- | LUAD-KRAS-mut | 0.5405 | 0.6299 | 0.4676 | 0.5110 | 0.4690 | 0.5480 | 0.6038 |
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- | BRCA-ER | 0.9343 | 0.8998 | 0.9115 | 0.9186 | 0.9454 | 0.9096 | 0.9278 |
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- | BRCA-PR | 0.8804 | 0.8613 | 0.8470 | 0.8595 | 0.8770 | 0.8215 | 0.8430 |
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- | BRCA-HER2 | 0.8046 | 0.8154 | 0.7822 | 0.7891 | 0.8322 | 0.7811 | 0.8050 |
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- | BRCA-TP53 | 0.7879 | 0.8415 | 0.7879 | 0.7388 | 0.8080 | 0.6607 | 0.7656 |
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- | BRCA-PIK3CA | 0.7577 | 0.8929 | 0.7015 | 0.7347 | 0.8571 | 0.7066 | 0.7908 |
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- | RCC-PBRM1 | 0.6383 | 0.5570 | 0.5129 | 0.5270 | 0.5011 | 0.4445 | 0.5780 |
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- | RCC-BAP1 | 0.7188 | 0.7690 | 0.7310 | 0.6970 | 0.7160 | 0.7337 | 0.7323 |
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- | COAD-KRAS | 0.7642 | 0.7443 | 0.6989 | 0.8153 | 0.9432 | 0.6790 | 0.8693 |
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- | COAD-TP53 | 0.8889 | 0.8160 | 0.7014 | 0.7118 | 0.7830 | 0.8785 | 0.8715 |
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- | <span style="color:red">**Average**</span> | 0.7817 | 0.7869 | 0.7299 | 0.7457 | <u>0.7876</u> | 0.7356 | <span style="color:red">**0.7932**</span> |
 
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  - EXAONEPath-1.5
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  - pathology
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  ---
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+ <!--# EXAONE Path for CRCMSI – CRCMSI-centric Whole-Slide Image Classifier
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+ *A purpose-built upgrade of **EXAONE Path 1.5***-->
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  ## Introduction
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+ <!--**EXAONE Path for CRCMSI** is an **enhanced whole-slide image (WSI) classification framework** that retains the core architecture of EXAONE Path 1.5 while upgrading its internals for greater efficiency and richer multimodal integration.-->
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+ **EXAONE Path MSI** is an **enhanced whole-slide image (WSI) classification framework** that retains the core architecture of EXAONE Path while upgrading its internals for greater efficiency and richer multimodal integration.
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  The pipeline still unfolds in two stages:
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+ 1. **Patch-wise feature extraction** – Each WSI is tiled into 256 × 256 px patches, which are embedded into 768-dimensional vectors using the frozen **[EXAONE Path](https://huggingface.co/LGAI-EXAONE/EXAONEPath)** encoder.
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  2. **Slide-level aggregation** – The patch embeddings are aggregated using a Vision Transformer, producing a unified slide-level representation that a lightweight classification head transforms into task-specific probabilities.
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  ---
 
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  ### Model Performance Comparison
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+ | Metric (AUC) / Task | Titan (Conch v1.5 + iBot, image-text) | PRISM (virchow + perceiver, image-text) | CHIEF (CTransPath + CLAM, image-text, WSI-contrastive) | Prov-GigaPath (GigaPath + LongNet, image-only, mask-prediction) | UNI2-h + CLAM (image-only) | EXAONE Path MSI |
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+ |------------------------------------|---------------------------------------|-----------------------------------------|--------------------------------------------------------|-----------------------------------------------------------------|---------------------------|------------------------|
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+ | **CRC-MSI** | 0.9370 | 0.9432 | 0.9273 | 0.9541 | <u>0.9808</u> | **0.9844** |
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+ <!--| LUAD-TMB (cutoff 10) | 0.6901 | 0.6445 | 0.6501 | 0.6744 | 0.6686 | 0.6846 | |
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+ | LUAD-EGFR-mut | 0.8197 | 0.8152 | 0.7691 | 0.7623 | 0.8577 | 0.7607 | |
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+ | LUAD-KRAS-mut | 0.5405 | 0.6299 | 0.4676 | 0.5110 | 0.4690 | 0.5480 | |
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+ | BRCA-ER | 0.9343 | 0.8998 | 0.9115 | 0.9186 | 0.9454 | 0.9096 | |
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+ | BRCA-PR | 0.8804 | 0.8613 | 0.8470 | 0.8595 | 0.8770 | 0.8215 | |
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+ | BRCA-HER2 | 0.8046 | 0.8154 | 0.7822 | 0.7891 | 0.8322 | 0.7811 | |
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+ | BRCA-TP53 | 0.7879 | 0.8415 | 0.7879 | 0.7388 | 0.8080 | 0.6607 | |
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+ | BRCA-PIK3CA | 0.7577 | 0.8929 | 0.7015 | 0.7347 | 0.8571 | 0.7066 | |
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+ | RCC-PBRM1 | 0.6383 | 0.5570 | 0.5129 | 0.5270 | 0.5011 | 0.4445 | |
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+ | RCC-BAP1 | 0.7188 | 0.7690 | 0.7310 | 0.6970 | 0.7160 | 0.7337 | |
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+ | COAD-KRAS | 0.7642 | 0.7443 | 0.6989 | 0.8153 | 0.9432 | 0.6790 | |
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+ | COAD-TP53 | 0.8889 | 0.8160 | 0.7014 | 0.7118 | 0.7830 | 0.8785 | |
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+ | <span style="color:red">**Average**</span> | 0.7817 | 0.7869 | 0.7299 | 0.7457 | <u>0.7876</u> | <span style="color:red">**0.7932**</span> |-->