Meissa-4B: Multi-modal Medical Agentic Intelligence

Meissa-4B is a lightweight 4B-parameter medical multi-modal LLM with full agentic capability. Instead of relying on proprietary frontier models (GPT, Gemini), Meissa brings tool calling, multi-agent collaboration, and clinical simulation offline by distilling structured trajectories from frontier agent systems into a compact vision-language model.

Key Features

• 4 agentic paradigms in a single model: continuous tool calling, interleaved thinking with images, multi-agent collaboration, and multi-turn clinical simulation
• Offline deployment: runs entirely locally with vLLM, no API calls needed
• Tool calling: native <tool_call> support via Hermes format, compatible with vLLM's tool-call parser
• Thinking: built-in <think> chain-of-thought reasoning before actions

Model Details

Base model	Qwen3-VL-4B-Instruct
Architecture	Qwen3VLForConditionalGeneration
Parameters	4B
Precision	bfloat16
Training method	LoRA SFT (rank=32, alpha=64), merged
Training data	43,210 medical agentic trajectories (open subset)
Training framework	LLaMA-Factory
Context length	8,192 tokens (training)

Quickstart

Load with Transformers

from transformers import AutoModelForCausalLM, AutoProcessor

model = AutoModelForCausalLM.from_pretrained(
    "CYX1998/Meissa-4B",
    trust_remote_code=True,
    torch_dtype="bfloat16",
    device_map="auto",
)
processor = AutoProcessor.from_pretrained("CYX1998/Meissa-4B", trust_remote_code=True)

Serve with vLLM (Recommended)

For agentic use cases, serve Meissa with vLLM to enable tool calling:

python -m vllm.entrypoints.openai.api_server \
    --model CYX1998/Meissa-4B \
    --port 8877 \
    --max-model-len 8192 \
    --gpu-memory-utilization 0.85 \
    --dtype bfloat16 \
    --enable-auto-tool-choice \
    --tool-call-parser hermes

# Set the endpoint
export OPENAI_BASE_URL="http://127.0.0.1:8877/v1"
export OPENAI_API_KEY="dummy"

The --enable-auto-tool-choice --tool-call-parser hermes flags are required for tool calling.

Example: Tool Calling

from openai import OpenAI

client = OpenAI(base_url="http://127.0.0.1:8877/v1", api_key="dummy")

tools = [{
    "type": "function",
    "function": {
        "name": "ChestXRayClassifier",
        "description": "Classify pathologies in a chest X-ray image.",
        "parameters": {
            "type": "object",
            "properties": {
                "image_path": {"type": "string", "description": "Path to the chest X-ray image"}
            },
            "required": ["image_path"]
        }
    }
}]

response = client.chat.completions.create(
    model="CYX1998/Meissa-4B",
    messages=[{"role": "user", "content": "Analyze this chest X-ray: /path/to/cxr.jpg"}],
    tools=tools,
)
print(response.choices[0].message)

Supported Agentic Frameworks

Framework	Description	Tools
I: Continuous Tool Calling	Sequential tool use for radiology analysis	8 chest X-ray tools (classifier, report generator, VQA, segmentation, etc.)
II: Interleaved Thinking with Images	Iterative visual reasoning with zoom	ZoomInSubfigure, SegmentRegion, Terminate
III: Multi-Agent Collaboration	Multi-agent medical consultation	AssessDifficulty, RecruitExperts, ConsultExperts, FacilitateDebate
IV: Clinical Simulation	Multi-turn doctor-patient interaction	RequestPhysicalExam, RequestTest, Terminate

Training Data

Trained on 43,210 medical agentic SFT trajectories distilled from Gemini:

Framework	Samples	Source Datasets
I: Continuous Tool Calling	4,898	MIMIC-CXR-VQA
II: Interleaved Thinking	15,211	PathVQA, MIMIC-CXR-VQA, SLAKE, VQA-RAD
III: Multi-Agent Collaboration	15,427	MIMIC-CXR-VQA, PathVQA, MedQA, PubMedQA
IV: Clinical Simulation	7,674	MedQA, MIMIC-CXR

The open-source subset (25,018 samples) is available at CYX1998/Meissa-SFT.

Evaluation

Meissa-4B matches or exceeds GPT-4o and Gemini-3-flash on multiple medical agentic benchmarks while being deployable offline on a single GPU. See our paper for full results.

Limitations

• Not for clinical use: This model is a research prototype and should NOT be used for real clinical decision-making.
• English only: Trained and evaluated on English medical data only.
• Domain scope: Primarily trained on radiology, pathology, and general clinical reasoning. Performance on other medical specialties may vary.
• Hallucination: Like all LLMs, Meissa may generate plausible but incorrect medical information.

Citation

@inproceedings{chen2026meissa,
  title={Meissa: Multi-modal Medical Agentic Intelligence},
  author={Chen, Yixiong and Bai, Xinyi and Pan, Yue and Zhou, Zongwei and Yuille, Alan},
  journal={arXiv preprint arXiv:2603.09018},
  year={2026}
}

License

This model is released under Apache 2.0. The base model Qwen3-VL-4B-Instruct is subject to the Qwen License.