Liver Cell Biology Research Group

university

https://livr.research.vub.be/

LIVR-VUB

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Liver Cell Biology Research Group(LIVR)

Brussels Health Campus • Vrije Universiteit Brussel • Brussels • Belgium

Mission

Advance understanding of liver cell diversity, regeneration and fibrosis to drive novel biomarkers, in vitro disease models and therapeutic strategies for chronic liver disorders.

Research Objectives

Cellular Characterization
Profile healthy vs. diseased liver cell types at single‑cell resolution.
Fibrosis Mechanisms
Dissect pathways of hepatic stellate cell activation, fibrogenesis and resolution.
Biomarker Discovery
Identify stellate‑cell‑specific markers for non‑invasive fibrosis staging.
Disease Modeling
Build iPSC‑derived liver cell co‑cultures and organoids to recreate MASLD and other chronic conditions.
Regeneration & Progenitors
Elucidate the role of liver progenitor cells in tissue repair.

Key Collaborations & Networks

ImAgE‑D (Marie Skłodowska‑Curie ITN, Oct 2023 – Sep 2027)
High‑speed, super‑resolution imaging of endothelial and liver cells.
DeLIVERy (EIC Pathfinder, May 2022 – Apr 2026)
Personalized polypharmacy testing on patient‑derived mini‑livers.

Publications & Resources

Latest Publications
- JHEP Reports: “HSC single‑cell atlas reveals activation across etiologies”
- Biofabrication: “iPSC‑derived liver spheroids to model fibrosis”
- Science: “Hippo signaling instructs ectopic organ growth”
Full Publication List:
Browse all publications (2010–present) Research Portal Click here.

Team & Training

Current Members | Former Members
Explore profiles and roles on our Team page.
Doctoral & Post‑doc Training
Interactive workshops, imaging courses, and 3R‑principle seminars for early‑career researchers.

News & Events

Belgian Stem Cell Meeting – Nov 28 2025 @ ULB Erasme Campus
Upcoming Seminars & “Film Nights” showcasing 3R approaches and mini‑liver therapies
Follow live updates in News & Events.