| # Data & Ethics | |
| ## Ancestry-Aware Modeling | |
| This software implements ancestry-aware antibody design, considering genetic and immunological variations across different populations. The model: | |
| - Incorporates HLA type matching (currently supporting 2 matches) | |
| - Considers ancestry-specific immune responses | |
| - Adapts to metabolic variations | |
| ## Ethics and Oversight | |
| - All sequences are logged with ancestry context | |
| - Ethical validation performed via CoreConscience system | |
| - Full traceability of design decisions | |
| - Rejection memory maintains record of discarded designs | |
| ## Ethics Statement | |
| This software is designed to promote inclusive and ethical antibody development. We are committed to preventing misuse and ensuring equitable benefit across populations. | |
| ## Concerns or Questions | |
| For ethics-related inquiries, please contact: | |
| Jonathan Harrison Light (ethics@healdette.org) | |
| ORCID: 0009-0003-7005-8187 | |
| ## Cross-References | |
| - GitHub Release: [v1.0.0](https://github.com/Raiff1982/healdette/releases/tag/v1.0.0) | |
| - Hugging Face Model: [healdette/protgpt2-ancestry](https://huggingface.co/healdette/protgpt2-ancestry) | |
| - DOI: [10.57967/hf/5917](https://doi.org/10.57967/hf/5917) |